PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS

Abstract: The present invention is related to new substituted pyrrolidine derivatives of formula (I). Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula (I) are useful in the treatment and/or prevention of neurodegenerative disorders, diseases associated with polygultamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders renal hypoxia, hepatitis and AIDS. Said pyrrolidine derivatives display a modulatory and most notably a down-regulating - up to an inhibitory - activity with respect to the cellular death agonist Bax and/or the activation pathways leading to Bax and allows therefore to block the release of cytochrome (c). The present invention is furthermore related to novel pharmaceutically activity substituted pyrrolidine derivatives as well as to methods of their preparation, wherein X is selected from the group consisting of O, S, CR<6>R<7>, NOR<6>, NNR<6>R<7>; A is selected from the group consisting of -(C=O)-, -(C=O)-O-, -C(=NH)-, -(C=O)-NH-, -(C=S)-NH, -SO2-, -SO2NH-; -CH2-; B is either a group -(C=O)-NR<8>R<9> or represents a heterocyclic residue having the formula (II) wherein Q is NR<10>, O or S; n is an integer selected of 0, 1 or 2; Y, Z and E form together with the 2 carbons to which they are attached a 5-6 membered aryl or heteroaryl ring.

Description: Pharmaceutically Active Pyrrolidine Derivatives as Bax Inhibitors Field ofthe invention The present invention is related to new substituted pyrrolidine derivatives of formula I. Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula I are useful in the treatment and/or prevention of neurodegenerative disorders, diseases associated with polyglutamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders, renal hypoxia, hepatitis and AIDS. Said pyrrolidine derivatives display a modulatory and most notably a down-regulating - up to an inhibitory - activity with respect to the cellular death agonist Bax and/or the activation pathways leading to Bax and allows therefore to block the release of cytochrome c. The present invention is furthermore related to novel pharmaceutically active substituted pyrrolidine derivatives as well as to methods of their preparation. Background ofthe mvention Apoptosis denotes the complex contortions ofthe membrane and organelles of a cell as it undergoes the process of programmed cell death. During said process, the cell activates an intrinsic suicide program and systematically destroys itself in a controlled manner or by a self- regulated process. The following series of events can be observed: • The cell surface begins to bleb and expresses pro-phagocytic signals. The whole apoptotic cell then fragments into membrane-bound vesicles that are rapidly and neatly disposed of by phagocytosis, so that there is minimal damage to the surrounding tissue. • The cell then separates from its neighbors. • The nucleus also goes through a characteristic pattern of morphological changes as it commits genetic suicide. The chromatin condenses and is specifically cleaved to fragments of DNA. Neuronal cell death plays an important role in ensuring that the nervous system develops normally. It appears that the death of developing neurons depends on the size ofthe target that they innervate : cells with fewer synaptic partners are more likely to die than those that have formed multiple synapses. This may reflect a process, which balances the relative number of pre- to postsynaptic neurons in the developing nervous system. Although neuronal cell death was assumed to be apoptotic, it was only recently-fhat neurons in developing rodent brain were conclusively shown to undergo apoptosis as classified by morphology and DNA fragmentation. Neuronal death occurs via either apoptotic or necrotic processes following traumatic nerve injury or during neurodegenerative diseases. Multiple components are emerging as key players having a role in driving neuronal programmed cell death. Amongst the components leading to neuronal apoptosis are protein members belonging to the Bcl-2 family (see Jacobson, M. D. 1997. Current Biology 7:R 277-R281; Kroemer, G. C. 1997. Nature Medicine : 614-620; Reed, J. C. 1997. Nature 387:773-776). The entire Bcl-2 family comprises both anti-apoptotic (Bcl-2, BC1-X L , Bcl-w, Mcl-1, Al, NR- 13, BHRF1, LMW5-HL, ORF16, KS-Bcl-2, E1B-19K, CED-9) and pro-apoptotic (Bax, Bak, Bok, Bik, Blk, Hrk, BNTP3, Bim , Bad, Bid, EGL-1) molecules (see Kelekar, A., and C. B. Thomp-son 1998. Trends in Cell Biology 8:324-330). The specific member thereof, i.e. the first found, Bcl-2 is a 26 kDa protein that localizes to the mitochondrial, endoplasmatic reticulum and perinuclear membranes. The Bcl-2 family proteins can form homo- and heterodimers that involve amino acid sequences known as Bcl-2 homology (BH) domains. So far, four of said domains (BH1 to 4) have been identified, the BH3 having been attributed a particularly prominent role in view ofthe death-promoting cascade. Said BH3 domain ofthe pro-apoptotic members appears to be required for the interaction between anti and pro- apoptotic molecules. The principal site of action of some ofthe Bcl-2 family members seems to be the mitochondria. Mitochondria have been shown to play a major role in many types of apoptosis. In particular, this organelle has been shown to release Apoptosis Inducing Factor and cytochrome c, a hemoprotein which is bound to the outer surface ofthe inner mitochondrial membrane. Said cytochrome c has been shown to trigger caspase 9 activation through Apaf-1/caspase 9 complex formation. Bcl-2 family members play a key role in regulating cytochrome c release. While Bcl-2 and BC1-X L have been shown to suppress cytochrome c release, Bax has been found to stimulate this event both in vitro using isolated mitochondria as well as in intact cells following heterologous expression (Martinou et al.; The Journal of Cell Biology, 128, 1995, 201-208). The mechanisms by which these proteins perform their function are currently unknown. The three-dimensional structure of Bcl-xL and Bid revealed structural similarities between these proteins and the channel-forming domains of the bacterial toxins colicins and diphtheria toxins. Consistent with such structural similarity, some members of this family including Bax were also found able to form ion channels in synthetic lipid membranes. Studies performed with B ax-deficient mice led to the conclusion that Bax plays a promi-nent role within the apoptosis pathways, notably in neuronal apoptosis. Bax is viewed to be essential for apoptosis induced by NGF deprivation in neonatal sympathetic neurons or for apoptosis induced in cerebellar granule cells by potassium deprivation from the culture medium. Moreover, it was found that in the Bax-deficient mice (knock-out) neonatal moto- neurons from the facial nucleus can survive following axotomy (see Deckwerth, T.L., Elliott J.L., Knudson CM. et al. 1996. Neuron 17, 401-41). Hence, the inhibition ofthe Bax activity leading to the prevention of cytochrome c release from mitochondria during apoptosis, is viewed to be useful to protect neurons and also other cell types from various cell death stimuli. In WO 97/01635 (Neurex Corp.) the inhibition of apoptosis in an effort to promote cell sur- vival is suggested to be achieved by introducing into the cell a chimeric gene containing a polynucleotide encoding a Bax-ω-polypeptide (a splice variant ofthe Bax gene, which displays - in contrast to Bax - an anti-apoptotic activity) being operably linked to a promoter effective to cause transcription ofthe polynucleotide in the cell. It is reported that the expression ofthe Bax-ω-polypeptide is effective to inhibit apoptosis in the cell. Perez et al. in Nat. Genet. 1999, 21(2), 200-203 have indicated that apoptosis plays a fundamental role in follicular atresia and they suggest to selectively disrupt the Bax function in order to extend the ovarian lifespan. Bax down-regulation up to inhibition could indeed represent an interesting therapy for all diseases associated with apoptosis, including neurodegenerative diseases (e.g. Alzheimer's disease, Parkinson's disease, diseases associated with polyglutamine tracts including Hun- tington's disease, spino-cerebellar ataxias and dentatorubral-pallidoluysian atrophy; amyotrophic lateral sclerosis, retinitis pigmentosa and multiple sclerosis, epilepsy), ischemia (stroke, myocardial infarction and reperfusion injury), infertility (like premature menopause, ovarian failure or follicular atresia), cardiovascular disorders (arteriosclerosis, heart failure and heart transplantation), renal hypoxia, hepatitis and AIDS. Hence, it is an objective ofthe present invention to provide compounds enabling the treatment of apoptosis-related disorders, including notably the above mentioned diseases. It is specifically an objective ofthe present invention to provide a treatment of apoptosis related disorders by specifically regulating the Bax function, e.g. by modulating, in particular by down-regulating up to inhibiting, the Bax function or by down-regulating, up to inhibiting, the Bax activation. It is notably an objective ofthe present invention to provide small molecule pharmaceuticals, more specifically non-protein or non-peptide molecules that avoid essentially all ofthe drawbacks arising from the use of large peptides or proteins (e.g. restricted bio-availability as well as problems arising from in vivo intolerance thereto), however, which are suitable for the treatment of a number of diseases associated with abnormal apoptosis. It is particularly an objective ofthe present invention to provide small molecule chemical compounds being suitable Bax modulators (e.g. compounds inhibiting the Bax function or inhibiting the Bax activation) so to be available for a convenient method of treating diseases involving abnormal apoptosis. Moreover, it is an objective ofthe present invention to provide methods for preparing said small molecule chemical compounds. It is furthermore an objective ofthe present invention to provide a new category of pharmaceutical formulations for the treatment of a host of diseases. It is finally an objective ofthe present invention to provide a method of treating diseases that are caused by abnormal apoptosis. Description ofthe invention The aforementioned objectives have been met according to the independent claims which are set out hereinafter in the description. Preferred embodiments are set out within the dependent claims. The following paragraphs provide definitions ofthe various chemical moieties that make up the compounds according to the invention and are intended to apply uniformly throughout the specification and claims unless an otherwise expressly set out definition provides a broader definition. "Cϋ-Cβ -alkyl" refers to monovalent alkyl groups having 1 to 6 carbon atoms. This term is exemplified by groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-hexyl and the like. "Aryl" refers to an unsaturated aromatic carbocyclic group of from 6 to 14 carbon atoms having a single ring (e.g. phenyl) or multiple condensed rings (e.g. naphthyl). Preferred aryl include phenyl, naphthyl, phenantrenyl and the like. "CrCβ-alkyl aryl" refers to -Ce-alkyl groups having an aryl substituent, including benzyl, phenefhyl and the like. "Heteroaryl" refers to a monocyclic heteromatic, or a bicyclic or a tricyclic fused-ring heteroaromatic group. Particular examples of heteroaromatic groups include optionally substituted pyridyl, pyrrolyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isofhiazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadia-zolyl, 1,2,5-oxadiazolyl, l,3,4-oxadiazolyl,l,3,4-triazinyl, l,2,3-triazmyl, benzofuryl, [2,3- dihydro]benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, isobenzothienyl, indolyl, isoindolyl, 3H-indolyl, benzimidazolyl, imidazo[l,2-a]pyridyl, benzothiazolyl, benzoxa-zolyl, quinolizinyl, quinazolinyl, pthalazinyl, quinoxalinyl, cinnnolinyl, napthyridinyl, pyrido[3,4- b]pyridyl, pyrido[3,2-b]pyridyl, pyrido[4,3-b]pyridyl, quinolyl, isoquinolyl, tetrazofyL 5,6,7,8- tetrahydroquinolyl, 5,6,7,8-tetrehydroisoquinolyl, purinyl, pteridinyl, carbazolyl, xanthenyl or benzoquinolyl. "C Cβ-alkyl heteroaryl" refers to Ci-Cβ-alkyl groups having a heteroaryl substituent, including 2-furylmethyl, 2-fhienylmethyl, 2-(lH-indol-3-yl)ethyl and the like. "Alkenyl" refers to alkenyl groups preferably having from 2 to 6 carbon atoms and having at least 1 or 2 sites of alkenyl unsaturation. Preferable alkenyl groups include ethenyl (-CH=CH 2 ), n-2-propenyl (allyl, -CH 2 CH=CH 2 ) and the like. "Alkynyl" refers to alkynyl groups preferably having from 2 to 6 carbon atoms and having at least 1-2 sites of alkynyl unsaturation, preferred alkynyl groups include ethynyl (-G≡CH), propargyl (-CH 2 C≡CH), and the like. "Acyl" refers to the group -C(O)R where R includes "C C 6 -alkyl", "aryl", "heteroaryl", "Ci- C 6 -alkyl aryl" or "C Ce-alkyl heteroaryl". "Acyloxy" refers to the group -OC(O)R where R includes "CrCe-alkyl", "aryl", "hetero- aryl", "C C 6 -alkyl aryl" or " -Ce-alkyl heteroaryl". "Alkoxy" refers to the group -O-R where R includes "CrCβ-alkyl" or "aryl" or "heteroaryl" or "CrC 6 -alkyl aryl" or " -Ce-alkyl heteroaryl". Preferred alkoxy groups include by way of example, methoxy, ethoxy, phenoxy and the like. "Alkoxycarbonyl" refers to the group -C(O)OR where R includes "Ci-C ό -alkyi" or "aryl" or "heteroaryl" or " -Ce-alkyl aryl" or "d-Ce-alkyl heteroaryl". "Aminocarbonyl" refers to the group -C(O)NRR' where each R, R' includes independently hydrogen or CrC 6 -alkyl or aryl or heteroaryl or "C C 6 -alkyl aryl" or "CrCβ-alkyl heteroaryl". "Acylamino" refers to the group -NR(CO)R' where each R, R' is independently hydrogen or "Ci-Cβ-alkyl" or "aryl" or "heteroaryl" or "d-Ce-alkyl aryl" or "C 1 -C 6 -alkyl heteroaryl". "Halogen" refers to fluoro, chloro, bromo and iodo atoms. "Sulfonyl" refers to group "-SO 2 -R" wherein R is selected from H, "aryl", "heteroaryl", "C Ce-alkyl", "Cι-C 6 -alkyl" substituted with halogens e.g. an -SO 2 -CF 3 group, " -Ce-alkyl aryl" or "CrCe-alkyl heteroaryl". "Sulfoxy" refers to a group "-S(O)-R" wherein R is selected from H, "d-Qs-alkyl", "d-C 6 - alkyl" substituted with halogens e.g. an -SO-CF 3 group, "aryl", "heteroaryl" , "d-C 6 -alkyl aryl" or "d-Cβ-alkyl heteroaryl". "Thioalkoxy" refers to groups -S-R where R includes "d-C δ -alkyl" or "aryl" or "heteroaryl" or "CrC 6 -alkyl aryl" or "d-Ce-alkyl heteroaryl". Preferred thioalkoxy groups include fhiomethoxy, thioethoxy, and the like. "Substituted or unsubstituted" : Unless otherwise constrained by the definition ofthe individual substituent, the above set out groups, like "alkyl", "alkenyl", "alkynyl", "aryl" and "heteroaryl" etc. groups can optionally be substituted with from 1 to 5 substituents selected from the group consisting of "Q-C 6 -alkyr, "Cι-C 6 -alkyl aryl", "Q-Ce-alkyl heteroaryl", "C 2 - C 6 -alkenyl", "C 2 -C 6 -alkynyl", primary, secondary or tertiary amino groups or quarter-nary ammonium moieties, "acyl", "acyloxy", "acylamino", "aminocarbonyl", "alkoxycar-bonyi", "aryl", "heteroaryl", carboxyl, cyano, halogen, hydroxy, mercapto, nitro, sulfoxy, sulfonyl, alkoxy, thioalkoxy, trihalomethyl and the like. Alternatively, said substitution could also comprise situations where neighboring substituents have undergone ring closure, notably when viccinal functional substituents are involved, thus forming e.g. lactams, lactons, cyclic anhydrides, but also acetals, thioacetals, aminals formed by ring closure for instance in an effort to obtain a protective group. "Pharmaceutically acceptable salts or complexes" refers to salts or complexes ofthe below- identified compounds of formula I that retain the desired biological activity. Examples of such salts include, but are not restricted to acid addition salts formed with inorganic acids (e.g. hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, and the like), and salts formed with organic acids such as acetic acid, oxalic acid, tartaric acid, succinic acid, malic acid, fumaric acid, maleic acid, ascorbic acid, benzoic acid, tannic acid, pamoic acid, alginic acid, polyglutamic acid, naphthalene sulfonic acid, naphthalene disulfonic acid, and poly-galacturonic acid. Said compounds can also be administered as pharmaceutically acceptable quaternary salts known by a person skilled in the art, which specifically include the quarternary ammonium salt ofthe formula -NR,R',R" + Z ~ , wherein R, R', R" is independently hydrogen, alkyl, or benzyl, and Z is a counterion, including chloride, bromide, iodide, -O-alkyl, toluenesulfonate, methylsulfonate, sulfonate, phosphate, or carboxylate (such as benzoate, succinate, acetate, glycolate, maleate, malate, fumarate, citrate, tartrate, ascorbate, cinnamoate, mandeloate, and diphenylacetate). "Pharmaceutically active derivative" refers to any compound that upon administration to the recipient, is capable of providing directly or indirectly, the activity disclosed herein. "Enantiomeric excess" (ee) refers to the products that are obtained by an essentially enan- tiomeric synthesis or a synthesis comprising an enantioselective step, whereby a surplus of one enantiomer in the order of at least about 52% ee is yielded. In the absence of an enantiomeric synthesis, racemic products are usually obtained that do however also have the inventive set out activity as modulators ofthe Bax function, e.g. Bax inhibitors (antagonists). Quite surprisingly, it was now found that the pyrrolidine derivatives according to formula I are suitable pharmaceutically active agents, notably by effectively modulating the Bax function or by modulating the Bax activation or expression. The compounds according to formula I are particularly interesting as they are preferably available to oral administration and therefore provide a good bio-availability. They could be prescribed by a physician and require only minor supervision. The compounds according to the present invention are those of formula I. I Said formula also comprises its geometrical isomers, its optically active forms as enantio- mers, diastereomers and its racemate forms, as well as pharmaceutically acceptable salts thereof. Preferred pharmaceutically acceptable salts ofthe compound I, are acid addition salts formed with pharmaceutically acceptable acids like hydrochloride, hydrobromide, sulfate or bisulfate, phosphate or hydrogen phosphate, acetate, benzoate, succinate, fumarate, maleate, lactate, citrate, tartrate, gluconate, methanesulfonate, benzenesulfonate, and para- toluenesulfonate salts. In said formula I, X is selected from the group consisting of O, S, CR 6 Rτ»7 , NOR 0 , NNR »6°Rp»7 A is selected from the group consisting of -(C=O)-, -(C=O)-O-, -C(=NH)-,-(C=O)-NH-, (C=S)-NH, -SO 2 -, -SO 2 NH-, -CH 2 -. B is either an amido group ofthe formula -(C=O)-NR 8 R 9 or B represents a heterocyclic residue having the formula B 1 wherein Q is NR 10 , O or S; n is an integer selected of 0, 1 or 2, preferably 0. m is an integer selected of 0, 1, 2 or 3, preferably 0 or 1. Y, Z and E form together with the 2 carbons to which they are attached a 5-6 membered aryl or heteroaryl ring. R 1 is selected from the group comprising or consisting of unsubstituted or substituted d-C 6 - alkyl, unsubstituted or substituted C 2 -C 6 -alkenyl, unsubstituted or substituted C 2 -C 6 -alkynyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl, acyl, unsubstituted or substituted Ci-Cβ-alkyl aryl, unsubstituted or substituted d-C 6 -alkyl heteroaryl, said cycloalkyl or aryl or heteroaryl groups maybe fused with 1-2 further cycloalkyl or aryl or heteroaryl group. R 2 , R 3 , R 4 and R 5 are independently selected from each other from the group consisting of hydrogen, halogen, d-d-alkyl, d-Q-alkoxy, preferably they are all hydrogen. R 6 and R 7 are independently selected from the group comprising or consisting of hydrogen, unsubstituted or substituted d-C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted thioalkoxy, halogen, cyano, nitro, acyl, alkoxycarbonyl, aminocarbonyl, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl which may contain 1 to 3 heteroatoms selected of N, O, S, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted d-Cβ-alkyl aryl, unsubstituted or substituted d-C 6 -alkyl heteroaryl. R 8 , R 9 and R 10 are independently selected from the group comprising or consisting of hydrogen, unsubstituted or substituted d-C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl which may contain 1 to 3 heteroatoms selected of N, O, S, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl. Alternatively, each pair R 6 , R 7 and/or R 8 , R 9 could form together with the N atom to which they are attached a 3-8 membered saturated or unsaturated substituted or unsubstituted heterocyclic ring which may contain 1-2 further heteroatoms selected from N, S and O and which is optionally fused with an aryl, heteroaryl or 3-8 membered saturated or unsaturated cycloalkyl ring. R 11 is selected from the group comprising or consisting of hydrogen, unsubstituted or substituted d-C 6 -alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, hydroxy, mercapto, alkoxy, thioalkoxy, aryl, heteroaryl, halogen, nitro, cyano, acyl, acyloxy, acylamino, aminocarbonyl, alkoxycarbonyl, sulfonyl, sulfoxy, carboxyl, primary, secondary or tertiary amino groups or quarternary ammonium moieties, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl. Preferred pyrrolidine derivatives are those compounds according to formula I, wherein B is a group -(C=O)-NHR 9 , in which R 9 is selected from the group consisting of unsubstituted or substituted d-C 6 alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted saturated or unsaturated 3-6-membered cycloalkyl which optionally contains a N atom, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted C 1 -C 2 -alkyl aryl, unsubstituted or substituted C 1 -C 2 - alkyl heteroaryl. Preferred heteroaryls are pyridyl, pyrrolyl, furyl, fhienyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4- oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-triazinyl, 1,2,3 -triazinyl, benzo-furyl, [2,3-dihydro]benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, isobenzothienyl, 2,1,3- benzothiadiazolyl, 2,1,3-benzoxadiazolyl, benzodioxolyl, indolyl, isoindolyl, 3H-indolyl, benzimidazolyl, imidazo[l,2-a]pyridyl, benzothiazolyl, benzoxazolyl, quinolizinyl, quinazolinyl, phthalazinyl, quinoxalinyl, cinnnolinyl, napthyridinyl, pyrido[3,4-b]pyridyl, pyrido[3,2-b]pyridyl, pyrido[4,3-b]pyridyl, quinolyl, isoquinolyl, tetrazolyl, 5,6,7,8- tetrahydroquinolyl, 5,6,7,8-tetrahydroisoquinolyl, purinyl, pteridinyl, carbazolyl, xanthenyl, acridinyl or benzoquinolyl and whereby said heteroaryl could be fused with a 3-8-membered cycloalkyl containing optionally 1-3 heteroatoms selected from N, O, S. According to a further preferred embodiment the pyrrolidine derivatives according to the present invention carry a residue B 1 which is a fused heterocycle ofthe formula Particularly preferred pyrrolidine derivatives are those compounds according to formula I wherein X is NOR 6 , and R 6 is selected from the group consisting of H, unsubstituted or substituted d-C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, unsubstituted or substituted acyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted saturated or unsaturated 3- 8-membered cycloalkyl, unsubstituted or substituted d-C 6 -alkyl aryl, unsubstituted or substituted d-C 6 -alkyl heteroaryl, said cycloalkyl or aryl or heteroaryl groups maybe fused with 1-2 further cycloalkyl or aryl or heteroaryl groups. Particularly preferred R 6 is H, CH 3 , unsubstituted or substituted CH 2 -phenyl or allyl. Under no circumstances B could be a group COOR or a group -(C=O)NR(OR), whereby R is H, alkyl or acyl. Such compounds, notably having a group B = hydroxamic acid are described in WO 99/52868 as being potent inhibitors of metalloproteases. Further particularly preferred pyrrolidine derivatives are those compounds according to formula I wherein X is CHR 6 , and R 6 is selected from the group consisting of halogen, cyano, unsubstituted or substituted C 3 -C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted thioalkoxy, nitro, acyl, alkoxycarbonyl, aminocarbonyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl, unsubstituted or substituted d-Cδ-alkyl aryl, unsubstituted or substituted Cι-C 6 -alkyl heteroaryl, said cycloalkyl or aryl or hetero-aryl groups may be fused with 1-2 further cycloalkyl or aryl or heteroaryl groups. Particularly preferred R 6 is halogen, cyano, d-C 6 alkyl or an unsubstituted or substituted phenyl group. Further preferred pyrrolidine derivatives are those compounds according to formula I, wherein X is O. According to a further preferred embodiment the pyrrolidine derivatives have a substituent A being -(C=O)-, or -(C=O)-NH-, or -SO 2 -, most preferred is -(C=O)-. More preferred groups R 1 are unsubstituted or substituted d-Ce-alkyl, C 2 -C6-alkenyl, unsubstituted or substituted C 2 -C 6 -alkynyl, aryl, heteroaryl, saturated or unsaturated 3-8- membered cycloalkyl and still more preferred R 1 are d-C 6 -alkyl or aryl. A particularly preferred substituent R 1 is biphenyl. According to a most preferred embodiment, the pyrrolidine derivatives according to for-mula I are those wherein X is NOR 6 or =CHC1„ R 6 is a d-C ό -alkyl or aryl or d-Cg-alkyl aryl group, B is an amido group ofthe formula -(C= : O)NHR 9 ), wherein R 9 is as above defined, A is C=O and R 1 is a d-Ce-alkyl-aryl, an aryl or a d-Cβ-alkyl group. Even more preferred are those pyrrolidine derivatives, wherein X is either =CH-C1, or =NOR 6 , R 6 is a methyl or phenyl group, B is an amido group ofthe formula -(C=O)NHR 9 ), wherein R 9 is a Ci-Ce-alkyl-aryl , an aryl, a d-Cβ-alkyl which is substituted by a primary, secondary or tertiary amine, A is C=O and R 1 is a diphenyl methyl or a phenyl group. The compounds of formula I may contain one or more asymmetric centers and may therefore exist as enantiomers or diasteroisomers. It is to be understood that the invention includes both mixtures and separate individual isomers or enantiomers ofthe compounds of formula I. In a particularly preferred embodiment the pyrrolidine derivatives according to formula I are obtained in an enantiomeric excess of at least 52 % ee, preferably of at least 92-98% ee. Also E/Z isomers with regard to pyrrolidine derivatives having residues X being =CR R whereby both R R are different from each other, and/or with regard to pyrrolidine derivatives having residues X being =NOR 6 or =NNR 6 R 7 are comprised by the present invention. Specific examples of compounds of formula I include the following: (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-(2-methoxyethyl)-4-(methoxyimino)-2-pyrro- lidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-[(2RS)-2-hydroxy-2- phenethyl] -2-pyrrolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl3-4-ylcarbonyl)-N-(2-hydroxyethyl)-4-(methoxyimino)-2-pyrro- lidinecarboxamide (2S,4EZ)-1 -([1,1 '-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-ρhenethyl]-4-(mefhoxy- imino)-2-pyrrolidinecarboxamide (3EZ,5S)-5-(lH-benzimidazol-2-yl)-l-([l,r-biρhenyl]-4-ylcarbonyl)-3-pyrrolidinone O- methyloxime (2S,4EZ)-N-(2,l,3-benzothiadiazol-4-yl)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-(methoxy-imino)- 2-pyrrolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-4-(methoxyimino)-N-(6-quinolinyl)-2-pyrrolidine- carboxamide (2S,4EZ)-l-acetoacetyl-N-benzyl-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-1 -([1 , 1 '-biphenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-(2-furylmethyl)-2- pyrrolidinecarboxamide (2S,4EZ)-l-[(4-chlorophenoxy)acetyl]-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-[(2RS)-2- hydroxy-2-phenefhyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-allyl- 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-4-(methoxyimino)-2-pyrrolidinecarbox- amide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-4-(methoxyimino)-N-(2-mienylme1hyl)-2-pyrroli- dinecarboxamide (2S,4EZ)-4-(cyanomethylene)-N-(2-furylmethyl)-l-[(2-oxo-6-pentyl-2H-pyran-3-yl)carbonyl]- 2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-N-(2-furylmethyl)-4-(methoxyimino)-2-pyrroli- dinecarboxamide (2S,4EZ)-l-acetyl-N-cyclopropyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarbox- amide (2S,4EZ)-N-(2-furylmethyl)-4-(methoxyimino)-l-[(2-oxo-6-pentyl-2H-ρyran-3-yl)car-bonyl]- 2-pyrrolidinecarboxamide (2S,4EZ)-N-benzyl- 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-4-(methoxyimino)-N-methyl-2-pyrroli- dinecarboxamide (2S,4EZ)-l-(diphenylacetyl)-4-(etnoxyimino)-N-^^ (2S,4EZ)-N-(2,l,3-benzotMadiazol-4-yl)-4-(cyanomef ylene)-l-(diphenylacetyl)-2-pyrroli- dinecarboxamide (3EZ,5S)-5-(lH-benzimidazol-2-yl)-l-(diphenylacetyl)-3-pyrrolidinone O-methyloxime (2S)-2-[ 1 -([1,1 '-biρhenyl]-4-ylcarbonyl)-4-methylene-2-pyrrolidinyl]- lH-benzimidazole (2S,4EZ)-1 -([1 , 1 '-biρhenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-(2-methoxyefhyl)-2- pyrrolidinecarboxamide (3EZ,5S)-5-(lH-benzimidazol-2-yl)-l-(diphenylacetyl)-3-pyrrolidinone O-allyloxime (2S,4EZ)-l-([l,r-biρhenyl]-4-ylcarbonyl)-N-[2-(diethylamino)ethyl]-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-l-(diphenylacetyl)-4-{[(4-methoxybenzyl)oxy]imino}-N-(2-thienylmefhyl)-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-(3,4-dimefhoxybenzyl)-4-(mefhoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-l-acetoacetyl-4-(methoxyimino)-N-(l-naphthylmethyl)-2-pyrrolidinecarboxamide (2S,4EZ)-N-allyl-4- { [(3,4-dichlorobenzyl)oxy]imino} - 1 -(diphenylacetyl)-2-pyrrolidinecar- box-amide (2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N ϊ -pentyl-N 2 -(6-quinolinyl)-l,2-pyrrolidine- dicarboxamide (2S,4EZ)-4-(chloromethylene)-l-(diphenylacetyl)-N-[(2RS)-2-hydroxy-2-phenethyl]-2-pyrroli- dinecarboxamide (2S)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenethyl]-4-methylene-2- pyrrolidine-carboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-(6-quinolinyl)-2-pyrroli- dinecarboxamide (2S,4E2)-4-benzylidene-N-[2-(diethylamino)ethyl]-l-(diphenylacetyl)-2-pyrrolidinecarbox- amide (2S,4EZ)-l-acetoacetyl-4-(methoxyimino)-N-(2-thienylmethyl)-2-pyrrolidinecarboxamide (2S,4EZ)-l-acetyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-[(2RS)-2-hydroxy-2-phenethyl]-2- pyrro-lidinecarboxamide (2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N 1 -(3,5-dichlorophenyl)-N 2 -(6-quinolinyl)-l,2- pyrrolidinedicarboxamide (2S,4EZ)-4-(mefhoxyimino)-N-( 1 -naphthylmethyl)- 1 -(phenoxyacetyl)-2-pyrrolidinecarbox- amide (2S,4EZ)-4-(chloromethylene)-N-(3,4-dimefhoxybenzyl)-l-[(2-oxo-6-pentyl-2H-pyran-3- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-(diphenylacetyl)-4-(methoxyimino)-N-(2-thienylmethyl)-2-pyrrolidinecarbox- amide (2S,4EZ)-N-benzyl-l-(diphenylacetyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-[2- (diethylamino)ethyl]-2-pyrrolidinecarboxamide (2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-l-[4-(dimefhylamino)butanoyl]-N-(6-quino- linyl)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-(5-ethyl-l,3,4-thiadiazol-2-yl)-4-(methoxy- imino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-benzyl- 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-4-(mefhoxyimino)-2-pyrrolidine- carboxamide (2S,4E^-N-benzyl-l-(diphenylacetyl)-4-(ethoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N 2 -cycloρroρyl-4- { [(3,4-dichlorobenzyl)oxy]imino} -N 1 -(3-methoxyphenyl)- 1 ,2- pyrrolidinedicarboxamide (2S,4EZ)-l-(diphenylacetyl)-N-[(2RS)-2-hydroxy-2-ρhenefhyl]-4-{[(4-methoxybenzyl)- oxyjimino} -2-pyrrolidinecarboxamide (2S)-N-(2-furylmethyl)-4-methylene-l-[(2-oxo-6-pentyl-2H-pyran-3-yl)carbonyl]-2- pyrrolidine-carboxamide (2S,4EZ)-N-(2,l,3-benzotMadiazol-4-yl)-l-(diphenylacetyl)-4-(methoxyiπώιo)-2-pyrrolidine- carboxamide (2S,4EZ)-N-benzyl-l-(diphenylacetyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine- carboxamide (2S,4EZ)- 1 -benzoyl-4- { [(3,4-dichlorobenzyl)oxy]imino} -N-(6-quinolinyl)-2-pyrrolidinecar- boxamide (2S,4EZ)-1 -acetoacetyl-N-cyclopropyl-4- {[(3,4-dichlorobenzyl)oxy]imino} -2- pyrrolidinecarboxamide (2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N 2 -[(2RS)-2-hydroxy-2-phenethyl]-N 1 -ρentyl- 1 ,2-pyrrolidinedicarboxamide (2S,4EZ)-4-[(^en2yloxy)imino]-N-(l-naphthylmethyl)-l-(phenoxyacetyl)-2-pyrrolidinecar- boxamide (2S)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-4-methylene-N-(6-quinolinyl)-2-ρyrrolidinecarbox- amide (2S,4EZ)-N-cyclopropyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-l-(diphenylacetyl)-2-pyrroli- dinecarboxamide (2S,4EZ)-l-(4-cyanobenzoyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-(6-quinolinyl)-2- pyrrolidinecarboxamide (2S,4EZ)-N-cyclopropyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-l-(methoxyacetyl)-2-pyrroli- dinecarboxamide (2S,4EZ)-N-(1 ,3-benzodioxol-5-ylmethyl)-l -([1,1 '-biρhenyl]-4-ylcarbonyl)-4-(methoxy- imino)-2-pyrrolidinecarboxamide (3EZ,5S)-5-[(4-acetyl-l-piperazinyl)carbonyl]-l-acryloyl-3-pyrrolidinone O-(3,4-dichloro- benzyl)oxime (2S)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-(2-furyhnethyl)-4-methylene-2-pyrrolidinecarbox- amide (2S,4EZ)-4-(cyanomefhylene)-N-(3 ,4-dimethoxybenzyl)- 1 -[(2-oxo-6-pentyl-2H-pyran-3- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'-biphenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-1 -([ 1 , 1 '-biphenyl]-3-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-ρhenylefhyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-(4-benzoylbenzoyl)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-(3-ρhenoxybenzoyl)-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-(2-ρhenoxybenzoyl)-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'-biphenyl]- 4-yl)carbonyl]-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(2R)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'-biphenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-(2-hydroxyethyl)-4-(methoxyimino)-l-[(2'-mefhyl[l,r-biρhenyl]-4-yl)carbonyl]- 2-pyrrolidinecarboxamide (2S,4EZ)-N-(2-hydroxyethyl)-4-(mefhoxyimino)-N-methyl-l -[(2'-methyl[ 1 , 1 '-biphenyl] -4- yl)carbonyl] -2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(lS,2S,3R,4R)-3- (hydroxymethyl)bicyclo[2.2.1]hept-2-yl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-(trαn5-4-hydroxycyclohexyl)-4-(methoxyimino)- 2-pyrrolidinecarboxamide (2S,4E2)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-N-[(lR,2R)-2-(hydroxymethyl)cyclohexyl]-4- (methoxyimino)-2-pyπOlidinecarboxamide (2S,4EZ)-1 -([1,1 '-biρhenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-3-phenoxypropyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-3-phenoxypropyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-3-phenoxvpropyl]-4- (mefhoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-N-[( 1 -hydroxycyclohexyl)methyl] -4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(l-hydroxycyclohexyl)methyl]-4-(methoxyimino)-l-[4-(3-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(l-hydroxycyclohexyl)methyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-(3,4-dihydroxyphenyl)-2- hydroxyethyl]-4-(methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[4-(4-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4E^-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[4-(3-ρyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)- 1 -[4-(2-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2,3-dihydroxypropyl]-4-(methoxyimino)- 2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2,3-dihydroxypropyl]-4-(mefhoxyimino)- 2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-3-(4- methoxyphenoxy)propyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-3-(4-methoxyρhenoxy)ρropyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-1-([1 ,1 '-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-3-(4-methoxyphenoxy)- propyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxypropyl]-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxyproρyl]-4-(mefhoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 *-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-2-(2-naphthyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4-(mefhoxyimino)-l-[4-(4- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4-(mefhoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4-(methoxyimmo)-l-[4-(2- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-N-{(2RS)-3-[4-(acetylamino)ρhenoxy]-2-hydroxyρropyl}-l-([l,l'-biphenyl]-4- ylcarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-{(2R5)-3-[4-(acetylamino)phenoxy]-2-hydroxyproρyl}-4-(methoxyimino)-l-[4- (4-pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-{(2RS)-3-[4-(acetylamino)ρhenoxy]-2-hydroxyproρyl}-4-(mefhoxyimino)-l-[4- (3-pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-{(2RS)-3-[4-(acetylamino)phenoxy]-2-hydroxyproρyl}-l-([l,r-biphenyl]-4- ylsulfonyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2R)-2-hydroxy-2-phenylethyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(2R)-2-hydroxy-2-phenylethyl]-4-(memoxyimino)-l-[4-(4-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(2R)-2-hydroxy-2-ρhenylethyl]-4-(mefhoxyimino)-l-[4-(3-ρyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(2R)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[4-(2-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(2R)-2-hydroxy-2-phenylethyl]-4- (mefhoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l, -biphenyl]-4-ylcarbonyl)-N-(3-hydroxypropyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylsulfonyl)-N-(3-hydroxypropyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (3EZ,5S)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-5-[(4-hydroxy-4-phenyl- 1 -piperidinyl)carbonyl]-3- pyrrolidinone O-methyloxime (3EZ,5S)-5-[(4-hydroxy-4-phenyl-l-piρeridinyl)carbonyl]-l-[4-(4-pyridinyl)benzoyl]-3- pyrrolidinone O-methyloxime (3EZ,5S)-5-[(4-hydroxy-4-phenyl-l-piperidinyl)carbonyl]-l-[4-(3-pyridinyl)benzoyl]-3- pyrrolidinone O-methyloxime (3EZ,5S)- 1 -([ 1 , 1 '-biphenyl]-4-ylsulfonyl)-5-[(4-hydroxy-4-phenyl- 1 -piperidinyl)carbonyl]-3- pyrrolidinone O-methyloxime (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lS,2S)-2-hydroxycyclohexyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylsulfonyl)-N-[(lS,2S)-2-hydroxycyclohexyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-benzyl-l -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-(2-hydroxyethyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-N-benzyl-N-(2-hydroxyethyl)-4-(methoxyimino)-l-[4-(3-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (3EZ,5S)-l-([l,l'-biphenyl]-4-ylcarbonyl)-5-{[(3RS)-3-hydroxypiperidinyl]carbonyl}-3- pyrrolidinone O-mefhyloxime (3EZ,55)-5-{[(3RS)-3-hydroxypiperidinyl]carbonyl}-l-[4-(4-pyridinyl)benzoyl]-3- pyrrolidinone O-methyloxime (3EZ,5S)-5-{[(3RS)-3-hydroxypiperidinyl]carbonyl}-l-[4-(3-pyridinyl)benzoyl]-3- pyrrolidinone O-methyloxime (3EZ,5S)-l-([l,l'-biphenyl]-4-ylsulfonyl)-5-{[(3RS)-3-hydroxypiperidinyl]carbonyl}-3- pyrrolidinone O-methyloxime (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2- phenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lS,25)-2-hydroxy-l-(hydroxymethyl)-2-phenylethyl]-4-(mefhoxyimino)-l-[4-(4- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-ρhenylethyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l , -biphenyl]-4-ylsulfonyl)-N-[(lS,2S)-2-hydroxy-l-(hydroxymefhyl)-2- phenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-(2-anilinoefhyl)-l-([l,r-biphenyl]-4-ylcarbonyl)-4-(mefhoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-4-(methoxyimino)-l-[4-(4-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-4-(methoxyimino)-l-[4-(3-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-4-(methoxyimino)-l-[4-(2-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-l-([l,l'-biρhenyl]-4-ylsulfonyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (3EZ,5S)-l-([l,l , -biphenyl]-4-ylcarbonyl)-5-[(4-hydroxy-l-piρeridinyl)carbonyl]-3- pyrrolidinone O-methyloxime (3EZ,5S)-l-([l,r-biρhenyl]-4-ylsulfonyl)-5-[(4-hydroxy-l-ρiperidinyl)carbonyl]-3- pyrrolidinone O-methyloxime (2S,4EZ)-N-[(lS,2R,3S,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-l-([l,l'- biphenyl]-4-ylsulfonyl)-4-(mefhoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-(3-amino-3-oxopropyl)-l-([l,r-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(lS,2S,3R,4R)-3-(aminocarbonyl)bicyclo[2.2.1 ]hept-5-en-2-yl]-l -([1,1 '- biphenyl]-4-ylsulfonyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biρhenyl]-4-ylcarbonyl)-N-(4-hydroxybutyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylsulfonyl)-N-(4-hydroxybutyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(lR,2R)-2-(hydroxymethyl)cyclohexyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(lR,2S,3R,4S)-3-(hydroxymefhyl)bicyclo- [2.2.1]hept-2-yl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylsulfonyl)-N-[(lR,2S)-2-(hydroxymethyl)cyclohexyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4E and 4Z)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2'-mefhyl[l,r- biphenyl] -4-yl)carbonyl] -2-pyrrolidinecarboxamide (2S,4E and 4Z)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4E and 4Z)-N-[(2R)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l*- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[(lR,2S)-2-(hydroxymethyl)cyclohexyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-1 -([ 1 , 1 '-biρhenyl]-4-ylcarbonyl)-N-[2-hydroxy-l -(hydroxymefhyl)ethyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(lS,2R,3S,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-l-([l,r- biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lS,2S,3R,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-l-([l,l'- biphenyl] -4-ylcarbonyl)-4-(methoxyimino)-2-pyπOlidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2S)-2-hydroxy-2-phenylefhyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2RS)-3-({[(2S,4EZ)-l-([l,r-biρhenyl]-4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl]- carbonyl} amino)-2-hydroxypropanoic acid (2S,4EZ)-N-[(lR,2S)-2-(aminocarbonyl)cyclohexyl]-l-([l,l'-biphenyl]-4-ylcarbonyl)-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lRS)-2-hydroxy-l-methylethyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-(4- mtrophenyl)ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide 4-( { [(2S,4EZ)- 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl] carbonyl} - amino)butanoic acid (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-l-[(2'-methoxy[l,r-biρhenyl]-4-yl)carbonyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(2-naphthyl)ethyl]-l-[(2'-methoxy[l,l'-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lRS)-2-hydroxy-l-methylethyl]-4-(methoxyimino)-l-[(2'-mefhyl[l,l*-biphenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-4- (mefhoxyimino)-l -[(2'-methyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl] -2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-(4-mtroρhenyl)efhyl]-4- (methoxyimino)- 1 -[(2'-methoxy[ 1 , 1 '-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (3EZ,5S)-5-[(4-hydroxy-l-piperidinyl)carbonyl]-l-[(2 , -methyl[l,r-biphenyl]-4-yl)carbonyl]- 3-pyrrolidinone O-methyloxime (2S,4EZ)-N-[(lS,2S,3R,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-4- (methoxyimino)-l-[(2'-methyl[l, -biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-phenylethyl]-l-[(2'-methoxy[l,l'-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxypropyl]-4-(methoxyimino)- 1 -[(2'-mefhyl[l , 1 '-biphenyl] -4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2,3-dihydroxyproρyl]-4-(methoxyimino)-l-[(2'-methyl[l,r-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-(3-hydroxypropyl)-4-(methoxyimino)-l-[(2'-methyl[l,r-biρhenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-(2-amino-2-oxoethyl)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-N-(2-amino-2-oxoethyl)-4-(methoxyimino)- 1 -[(2'-methyl[ 1 , 1 '-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lS,2R,3S,4R)-3-(hydroxymefhyl)- bicyclo[2.2.1 ]hept-2-yl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lR,2S,3R,4S)-3-(hydroxymefhyl)bicyclo[2.2.1]hept-2-yl]-l-[(2'-methoxy[l,l'- biphenyl] -4-yl)carbonyl] -4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-(tra«j-4-hydroxycyclohexyl)-l-[(2'-methoxy[l,r-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lR,2R)-2-(hydroxymethyl)cyclohexyl]-l-[(2'-methoxy[l,l'-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-3-phenoxypropyl]-4-(methoxyimino)-l-[(2'-mefhyl[l,l'- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]-4-(mefhoxyimino)-l-[(2'- methyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl] -2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-hydroxyρhenyl)ethyl]-4-(methoxyimino)-l-[(2'- methoxy [ 1 , 1 '-biphenyl] -4-yl)carbonyl] -2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-l-[(2'-methyl[l,r- biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]- 1 -[(2'-methoxy[ 1,1'- biphenyl] -4-yl)carbonyl] -4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-(3,4-dihydroxyphenyl)-2-hydroxyefhyl]-l-[(2'-methoxy[l,r-biphenyl]- 4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2R,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2R,4EZ)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l -[(2'-methyl[ 1 , 1 '-biphenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2'-cyano[l,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-phenylethyl]-4- (mefhoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(3',4'-dichloro[l,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2- phenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimefhyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2- phenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-phenylethyl]- 4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(2'- methylf 1 , 1 '-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(2'- cyano[l,l'-biphenyl]-4-yl)carbonyl]-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyρhenyl)ethyl]-4-(methoxyimino)-l-[(3',4'- dichloro [1,1 '-biphenyl] -4-yl)carbonyl] -2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(2',6'- dimethyl[l, -biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(2',3- dimefhyl[l,r-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(3',4'-dichloro[l,l*-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-(4- hydroxyphenyl)ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-(4- hydroxyphenyl)ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,l , -biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-(4- hydroxyphenyl)ethyl] -4-(methoxyimino)-2-pyrroIidinecarboxamide (2S,4EZ)-1 -[(2*,6'-dimethyl[ 1 ,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-3-(4- mefhoxyphenoxy)propyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-3-(4- methoxyphenoxy)propyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-(2-amino-2-oxoefhyl)-l -[(2',6'-dimethyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl] -4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-(2-amino-2-oxoethyl)-l-[(2',3-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-(3-amino-3-oxoρroρyl)-l-[(2*,6'-dimethyl[l,l'-biρhenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-(3-amino-3-oxopropyl)- 1 -[(2',3-dimefhyl[l , 1 '-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[2-hydroxy-l- (hydroxymefhyl)ethyl] -4-(methoxyimino)-2-ρyrrolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[2-hydroxy-l-(hydroxy- methyl)ethyl]-4-(methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-l-[(2'-cyano[l,l'-biphenyl]-4-yl)carbonyl]-N-[(lR,2R)-2-(hydroxymethyl)- cyclohexyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (3EZ,5S)-5-(3,4-dihydro-2(lH)-isoquinolinylcarbonyl)-l-[(2',3-dimefhyl[l,l'-biphenyl]-4- yl)carbonyl]-3-pyrrolidinone O-methyloxime (2S,4EZ)-N-[(lR)-2-hydroxy-l-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'-biρhenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ 1 -[(2',6'-dimethyl[ 1 , 1 '-biphenyl]-4-yl)carbonyl]-N-[2-(4-hydroxyphenyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[2-(4-hydroxyphenyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2*,6'-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[2-(3-hydroxyphenyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[2-(3-hydroxyphenyl)efhyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)- l-[(2',3-dimethyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl]-N-[(lR,2S)-2-hydroxy- 1 ,2- diphenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2RS)-2-[({(2S,4EZ)-4-(methoxyimino)-l-[(2'-methyl[l,l'-biphenyl]-4-yl)carbonyl]- pyrrolidinyl}carbonyl)amino]-3-phenylpropanoic acid (2S,4EZ)-N-[(lR,2S)-2-(aminocarbonyl)cyclohexyl]-l-[(2',6'-dimethyl[l,r-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lR,2S)-2-(aminocarbonyl)cyclohexyl]-l -[(2',3-dimefhyl[ 1 ,l'-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide 4'- {[(2S,4EZ)-2- {[4-(2-hydroxyethyl)-l -piperazinyl]carbonyl} -4-(mefhoxyimino)- pyrrolidinyl] carbonyl} [1,1 '-biphenyl] -2-carbonitrile (3EZ,5S)-l-[(3',4'-dichloro[l,l'-biphenyl]-4-yl)carbonyl]-5-{[4-(2-hydroxyefhyl)-l- piperazinyl] carbonyl} -3 -pyrrolidinone O-mefhyloxime (3EZ,5S)-l-[(2',6'-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-5-{[4-(2-hydroxyethyl)-l- piperazinyl]carbonyl}-3-pyrrolidinone O-methyloxime (3EZ,5S)-l-[(2',3-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-5-{[4-(2-hydroxyefhyl)-l- piperazinyl]carbonyl} -3 -pyrrolidinone O-mefhyloxime (3EZ,5S)-l-[(2'-methyl[l,l , -biphenyl]-4-yl)carbonyl]-5-({4-[4-(trifluoromefhyl)phenyl]-l- piperazinyl} carbonyl)-3 -pyrrolidinone O-methyloxime (3EZ,5S)-l-[(2'-methyl[l,l'-biphenyl]-4-yl)carbonyl]-5-({4-[3-(trifluoromethyl)phenyl]-l- piperazinyl} carbonyl)-3 -pyrrolidinone O-methyloxime (2S,4EZ)-4-(methoxyimino)-l-[(2'-mefhyl[l,r-biphenyl]-4-yl)carbonyl]-2-pyrrolidine- carboxamide (2S,4EZ)-4-(methoxyimino)-N-methyl- 1 -[(2'-methyl[ 1 , 1 '-biphenyl]-4-yl)carbonyl]-2- pyrrolidinecarboxamide (2S,4EZ)-4-(methoxyimino)-NN-dimethyl-l-[(2'-mefhyl[l,l'-biρhenyl]-4-yl)carbonyl]-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(3R)-3-hydroxy-3-ρhenylρropyl]-4-(methoxyimino)- 1 -[(2'-methyl[ 1 , 1 '-biphenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4E^-N-[(3S)-3-hydroxy-3-ρhenylpropyl]-4-(methoxyimino)-l-[(2'-methyl[l,r-biphenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[(3R)-3-hydroxy-3-ρhenylpropyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l*-biphenyl]-4-ylcarbonyl)-N-[(3S)-3-hydroxy-3-phenylpropyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-{[2'-(trifluoro-methyl)[l,r- biphenyl] -4-yl] carbonyl} -2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-{[2'-chloro[l,l'-biphenyl]-4- yl] carbonyl} -2 -pyrrolidinecarboxamide (2S,4EZ)-N-(2-hydroxyphenyl)-4-(methoxyimino)-l-[(2'-mefhyl[l,r-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[2-(hydroxymethyl)phenyl]-4-(mefhoxyimino)- 1 -[(2'-methyl[ 1 , 1 '-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(mefhoxyimino)-l-[(2-mefhyl[l,l'-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4E and 4Z)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-4-(methoxyimino)-l-[(2'-methyl[l,r-biρhenyl]-4-yl)carbonyl]-N-(2-phenylethyl)-2- pyrrolidinecarboxamide (2S)- 1 -(diphenylacetyl)-N-(l -naphthylmethyl)-4-oxo-2-pyrrolidinecarboxamide (2S)-Nl-(3,5-dichlorophenyl)-N2-(3,4-dimethoxybenzyl)-4-oxo-l,2-pyrrolidine- dicarboxamide (2S)-4-oxo- 1 -(phenoxyacetyl)-N- [2-( lH-pyrrol- 1 -yl)phenyl] -2-pyrrolidinecarboxamide Thereby, the most preferred compounds are those which are selected from the group consisting of: (4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[2-(diethylamino)ethyl]-4-{[(4-methoxybenzyl)- oxy]imino} -2-pyrrolidinecarboxamide (4EZ)-N 2 -(2-hydroxyethyl)-4-(methoxyimino)-N 1 -pentyl- 1 ,2-pyrrolidinedicarboxamide (4EZ)-4-benzylidene-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[2-(diefhylamino)ethyl]-2-pyrro- lidinecarboxamide (4EZ)-4-[(allyloxy)immo]-l-(4-cyanobenzoyl)-N-[2-(lH-pyrrol-l-yl)phenyl]-2 -pyrrolidinecarboxamide (4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-(2-furylmefhyl)-l-[(2-oxo-6-pentyl-2H-pyran-3- yl)carbonyl]-2-pyrrolidinecarboxamide (4EZ)-4-(methoxyimino)-N 1 -(3 -methoxyphenyl)-N 2 -(2-fhienylmef yl)- 1 ,2-pyrrolidinedi- carboxamide (4EZ)-2- {[4-(l ,3-benzodioxol-5-ylmethyl)-l -ρiperazinyl]carbonyl} -4-(mefhoxyimino)-N- pentyl- 1 -pyrrolidinecarboxamide (2S,4EZ)-N-(2-hyά^oxyethyl)-4-(methoxyimino)-l-nonanoyl-2-pyrrolidinecarboxamide A further aspect ofthe present invention is related to the use ofthe pyrrolidine derivatives according to formula I for the preparation of pharmaceutical compositions for the treatment of diseases including Alzheimer's disease, Parkinson's disease, diseases associated with polyglutamine tracts including Huntingdon's disease, spinocerebellar ataxias and dentatorubral-pallidoluysian atrophy; amyotrophic lateral sclerosis, Crohn's disease, retinitis pigmentosa and multiple sclerosis, epilepsy), ischemia (stroke, myocardial infarction and reperfusion injury), infertility (like premature menopause, ovarian failure or follicular atresia), cardiovascular disorders (arteriosclerosis, heart failure and heart transplantation), renal hypoxia, hepatitis and AIDS. According to a preferred embodiment, the above cited diseases or disease states are treated by the modulation ofthe Bax function, or the modulation (e.g. the inhibition) ofthe activation or expression of Bax, respectively, via the use of compounds of formula I, whereby the term Bax function notably comprises the actually active form of Bax as an oligomer (see B. Antonsson et al. in Biochem.J., Vol. 345, 2000, pages 271-278). Through the modulation ofthe Bax function, a convenient method of treatment of disorders mediated by Bax is expected, including in particular neuronal disorders and/or disorders ofthe immune system. Said modulation could notably involve the inhibition ofthe activity (activation) and/or ofthe expression of Bax. Also, said modulation ofthe Bax function or activity could actually comprise the inhibition or disruption for instance ofthe Bid interaction with Bax, which has been shown to play a role within the context ofthe Bax activation leading to cytochrome c release (see J.C. Martinou et al. in The Journal of Cell Biology, Vol. 144, No. 5, March 8, 1999, pages 891-901). As a result ofthe inhibition ofthe Bax activation by Bid upon using the compounds according to formula I, the cytochrome c release could be inhibited or essentially blocked, thus providing a convenient means to modulate the above described apoptosis pathways. As a result, by said modulation ofthe apoptosis pathways a whole variety of disorders associated with abnormal apoptosis is expected to be treated. It is reported herein that the compounds of formula I are suitable to be used as a medicament, i.e. they are suitable for use in treating diseases, like disorders ofthe autoimmune system and neuronal system of mammals, notably of human beings. More specifically, the compounds according to formula I, alone or in the form of a pharmaceutical composition, are useful for the modulation, in particular for the inhibition, ofthe Bax function and/or the Bax activation. More specifically, the compounds according to formula I, alone or in the form of a pharmaceutical composition, are useful for the treatment or prevention of disorders associated with abnormal expression or activation of Bax. The compounds according to formula I could be employed alone or in combination with further pharmaceutical agents. The compounds of formula I are suitable to be used as a medicament alone or in the form of a pharmaceutical composition together with suitable carriers, diluents or excipients. The compounds of formula I are suitable to be used for the preparation of orally administrated pharmaceutical compositions. Thus, according to the present invention, compounds pursuant to formula I are particularly useful for the treatment or prevention of immuno- and/or neuronal-related diseases or pathological states in which preferably the modulation, in particular the inhibition, ofthe Bax function and/or the Bax activation plays a crucial role, such as neurodegenerative diseases (e.g. Alzheimer's disease, Parkinson's disease, diseases associated with polyglutamine tracts including Huntington's disease, spinocerebellar ataxias and dentatorubral-pallidoluysian atrophy; amyotrophic lateral sclerosis, Crohn's disease, retinitis pigmentosa and multiple sclerosis, epilepsy), ischemia (stroke, myocardial infarction and reperfusion injury), infertility (like premature menopause, ovarian failure or follicular atresia), cardio-vascular disorders (arteriosclerosis, heart failure and heart transplantation), renal hypoxia, hepatitis and AIDS. Still a further aspect ofthe present invention is related to the actually novel pyrrolidine compounds of formula I. Some very few compounds have actually been disclosed prior to the filing ofthe present application, without any medical use though. Said known compounds of formula I are those, wherein X is (=CH 2 ), A is -(C=O)-O-, R 1 is a t-butyl group and B is -(C=O)-NMe 2 (Tetrahedron 53(2), 539, 1997); -(C=O)-NHMe (WO 95/47718); -(C=O)-NH-CH(Me)-(C=O)-NH-CH(Me COOH (WO 95/47718); or -(C=O)-NH-CH(COOCH 2 -Ph)-CH 2 -COOPh (Tetrahedron 48(31), 6529, 1992). X is (=CHR 6 ) with R 6 being cyclohexylmethyl, A is -(C=O)-O-, R 1 is a t-butyl group and is - (C=O)-NH-t-butyl (Biorg.Chem.Lett. 3(8), 1485, 1993). X is d-C 2 o alkylidene, A is -(C=O)- -, R 1 is a. t-butyl and B is wherein R is d-C 12 alkyl and Hal is Cl, Br, J. Said compounds are disclosed in DE-1, 932,823 as intermediates. X is d-C 2 o alkylidene, A-R 1 is a protective group and B is with R being H or d-C 12 alkyl (GB-1,118,306) Also excluded are the following compounds : which is disclosed in WO 00/08015 as being an FSH agonist. which is disclosed in Bioorg. Med. Chem. (1996), 4(8), pp.1365-77 as being useful for the treatment of infections. whereimPin is -NH-CH[C 6 H 3 (OMe) 2 ]C 6 H 4 OCHCO-Gly-NH(CH 2 ) 6 NH-MA/DMA- polyethylene pin (Tetrahedron Letters, Vol. 36 (1995) No.28, pp.5081-5084). No biological activity is disclosed for said molecule. The above two compounds are disclosed in J. Med. Chem, 29 (1986) pp.959-971 for their ability to reverse electroconvulsive shock-induced amnesia in rodents. Int. J. Pept. Protein Res. (1982), 20(5), pp.438-42. ). No biological activity is disclosed for said molecule. Hence, the novel compounds are those ofthe formula I, wherein the above mentioned known compounds are excluded. Still a further object ofthe present invention is a process for preparing the pyrrolidine derivatives according to formula I. The pyrrolidine derivatives exemplified in this invention can be prepared from readily available starting materials using the following general methods and procedures. It will be appreciated that where typical or preferred experimental conditions (i.e. reaction tempera- tures, time, moles of reagents, solvents, etc.) are given, other experimental conditions can also be used unless otherwise stated. Optimum reaction conditions may vary with the parti-cular reactants or solvents used, but such conditions can be determined by one skilled in the art by routine optimisation procedures. Generally, the pyrrolidine derivatives according to the general formula I could be obtained by several processes, using both solution-phase and solid- phase chemistry protocols. Depending on the nature of A, B, and X, certain processes will, in some instances, be preferred over others, and it is assumed that the choice ofthe most suitable process will be obvious to the practitioner skilled in the art. According to one process, pyrrolidine derivatives according to the general formula I, whereby the substituent B is C(O)-NR 8 R 9 , with R 8 and R 9 being defined as above, are prepared from the corresponding suitably N-protected 4-substituted pyrrolidine derivatives II, whereby the substituent X is as above defined, by solution-phase chemistry protocols such as described in the Examples and shown in Scheme 1, below. The suitably N-protected 4-substituted pyrrolidine derivatives II are first reacted with primary or secondary amines III, whereby the substituents R 8 and R 9 are as above defined, using conditions and methods well known to those skilled in the art to prepare an amide from an amine and a carboxylic acid or a carboxylic acid derivative, using standard peptide coupling agents, such as e.g. DIG, EDC, TBTU, DECP, or others, to yield compounds of formula IV. Removal of the N-protecting group using the appropriate deprotection agents produces deriva-tives of formula V. These can be treated with acylating agents of general formula VI, whereby the substituent R 1 is as above defined, while LG could be any appropriate leaving group. Preferred acylating agents VI are acid chlorides (Via), used in conjunction with a tertiary amine base, or carboxylic acids (VIb), used in conjunction with a peptide coupling agent, e.g. from the above mentioned group, to yield the products of general formula I, with B being defined as C(O)Ν 8 R 9 (la). Scheme 1 II III IV Via (e.g.,A=C(0);LG=CI) VIb (e.g.,A=C(0);LG=OH) la Other derivatives of formula I are prepared using known modifications to the Scheme 1 reaction sequence. Compounds of formula I wherein A is different from the carbonyl functionality are prepared by replacing formula VI compounds with compounds containing the appropriate functional groups, e.g. sulfonyl chlorides, isocyanates, isothiocyanates, chloroformates, substituted alkyl halides, or others to yield sulfonamide, urea, thiourea, carbamate, substituted alkyl derivatives, or others, respectively. Compounds of formula π, whereby the substituent X is CR 6 R 7 , and R 6 and R 7 are as above defined, can be prepared from compounds of general formula VII by Wittig-type reactions with anions of phosphor anes such as Villa and/or of phosphonates such as Vπib, followed by saponification ofthe ester function using standard synthetic teclmiques, as hereinafter described in the Examples and shown in Scheme 2. Scheme 2 Vlllb Compounds of general formula VII can be prepared from commercially available, suitably N- protected 4-hydroxyproline X, by a reaction sequence consisting of oxidation and esterification, using standard synthetic techniques as hereinafter described in the Examples and shown in Scheme 3. Scheme 3 X XI VII Compounds of formula π, wherein the substituent X is NOR 6 or NNR 6 R 7 , and R 6 and R 7 are as above defined, can be prepared from compounds of general formula XI by reaction with substituted hydroxylamines Xlla and/or substituted hydrazines and/or hydrazides Xllb using standard synthetic techniques as hereinafter described in the Examples and shown in Scheme 4. Scheme 4 Xlla (X = N-0-R6) XI Xllb (X = N-N-R6R7) II Compounds of formula Xlla are commercially available or prepared by standard synthetic teclmiques as hereinafter described in the Examples. Compounds of formula II with X = S are accessible from the corresponding suitably protected ketopyrrolidine intermediates VII through standard functional group interconversion methods well known to the person skilled in the art, such as, e.g., by treatment with Lawesson's reagent or others (Pedersen, B. S. et al.; Bull Soc. Chim. Belg. 1978, 87, 223), followed by saponification. According to another process, pyrrolidine derivatives according to the general formula I, whereby the substituent B is a heterocyclic residue Bl as above defined, and the substituents are as above defined, are prepared from the corresponding suitably N-protected 4-substituted pyrrolidine derivatives II, whereby the substituent X is as above defined, by solution-phase chemistry protocols such as described in the Examples and shown in Scheme 5, below. The starting suitably N-protected 4-substituted pyrrolidine derivatives II are first reacted with ortho-substituted primary anilines of general formula XIII, whereby the substituents Q, Z, E, Y, and R 11 are as above defined, using standard peptide coupling agents, such as DIC, EDC, TBTU, DECP, or others, followed by exposure to dilute weak acid, such as acetic acid, in a suitable organic solvent, such as DCM, to promote cyclisation yielding compounds of formula XIV. Removal ofthe N-protecting group using the appropriate deprotection agents produces cyclic derivatives of formula XV. These can be treated with acylating agents of general formula VI, whereby the substituent R 1 is as above defined, while LG could be any appropriate leaving group. Preferred acylating agents VI are acid chlorides (Via), used in conjunction with a tertiary amine base, or carboxylic acids (VIb), used in conjunction with a peptide coupling agent, e.g. from the abovementioned group, to yield the products of general formula I, with B being defined as Bl (lb). Scheme 5 Other derivatives of formula I are prepared using known modifications to the Scheme 5 reaction sequence. Compounds of formula I wherein A is different from the carbonyl functionality are prepared by replacing formula VI with compounds containing the appropriate functional groups, e.g. sulfonyl chlorides, isocyanates, isothiocyanates, chloroformates, substituted alkyl halides, or others to yield sulfonamide, urea, thiourea, carbamate, substituted alkyl derivatives, or others, respectively. According to another general process, summarized in Scheme 6, pyrrolidine derivatives according to the general formula I, whereby the substituents A, B, X, and R 1 are as above defined, are prepared from compounds of formula XVI, using the synthetic techniques as outlined in Schemes 2 and 4. As further shown in Scheme 6, compounds of formula XVI are accessible either from XI, following, e.g., the synthetic methodologies introduced in Schemes 1 and 5, or from Ic through hydrolysis ofthe methyloxime moiety, e.g. under mild hydrolysis conditions as described hereinafter in the Examples. This present synthetic strategy is most preferred when X is NOH or NNR 6 R 7 , whereby the substituents R 6 and R 7 are as above defined. Scheme 6 Ic According to yet another process, pyrrolidine derivatives according to the general formula I, whereby the substituents A, B, X, and R 1 are as above defined, are prepared from the corresponding suitably N-protected 4-substituted pyrrolidine derivatives II, whereby the substituent X is above defined, by a solid-phase protocol such as described in the examples and shown in Scheme 7, below. The N-Boc-protected 4-substituted pyrrolidine derivative π is reacted e.g. with Kaiser oxime resin using standard carbodiimide-mediated coupling conditions well known to the practitioner skilled in the art, followed by Boc-deprotection with dilute TFA in DCM, or with BF 3* OEt 2 in dilute HOAc in DCM, to give compound XIX. The latter compound can be treated with acylating agents of general formula VI, whereby the substituent R 1 is as above defined, while LG could be any appropriate leaving group. Preferred - acylating agents VI are acid chlorides (Via), used in conjunction with a tertiary amine base, or carboxylic acids (VIb), used in conjunction with a peptide coupling agent, e.g. DIC or EDC, to yield products of general formula XX. Compounds of formula I wherein A is different from the carbonyl functionality are pre-pared by replacing formula VI with compounds containing the appropriate functional groups, e.g. sulfonyl chlorides, isocyanates, isothiocyanates, chloroformates, substituted alkyl halides, or others to yield sulfonamide, urea, thiourea, carbamate, substituted alkyl derivatives, or others respectively. In order to obtain the final compounds of general formula I, the linkage to the resin is cleaved by prolonged treatment with amines of general formulae III or XIII and low percentages of a weak acid, such as HOAc. The cycles within the below Scheme 7 illustrate the resign beads to which the corresponding compounds are linked during the solid phase synthesis. Other derivatives of formula I are prepared using known modifications to, or variations of, the Scheme 7 reaction sequence. Further to the above mentioned Kaiser oxime resin, other suitable reagents, notably resins, known to a person skilled in the art, could be employed for the solid-phase synthesis of compounds of general formula I. Scheme 7 XVII II XVIII XIX XIII The reaction sequences outlined in the above Schemes provides enantiomerically pure compounds of formula I, if enantiomerically pure starting materials are used. (R) as well as (S) enantiomers can be obtained depending upon whether (R) or (S) forms of commercially available compounds of formulas II, III, VI, and or X were used as the starting materials. However, the reaction sequences outlined in the above Schemes usually provides mixtures of (E) and (Z) isomers with respect to the substituents on the exocyclic double bond ofthe pyrrolidine ring. In all cases studied, these (E)/(Z)-isomers could be separated by standard chromatography techniques well known to the person skilled in the art, such as by reversed phase high-pressure liquid chromatography (HPLC) or silica gel flash chromatography (FC). The assignment ofthe absolute configuration ofthe exocyclic double bond was performed using NMR-techniques well described in the literature as will be known to the practitioner skilled in the art (for configurationnal assignements of e.g. oxime functionalities, see e.g. E. Breitmaier, W. Voelter Carbon-13 NMR Spectroscopy, 3rd Ed, VCH, 1987, p. 240). According to a further general process, compounds of formula I can be converted to alter- native compounds of formula I, employing suitable interconversion techniques such as hereinafter described in the Examples. If the above set out general synthetic methods are not applicable for obtaining compounds according to formula I and/or necessary intermediates for the synthesis of compounds of formula I, suitable methods of preparation known by a person skilled on the art should be used. In general, the synthesis pathways for any individual compound of formula I will depend on the specific substitutents of each molecule and upon the ready availability of intermediates necessary; again such factors being appreciated by those of ordinary skill in the art. For all the protection, de-protection methods, see Philip J. Kocienski, in "Protecting Groups", Georg Thieme Verlag Stuttgart, New York, 1994 and, Theodora W. Greene and Peter G. M. Wuts in "Protective Groups in Organic Synthesis", Wiley-Interscience, 1991. Compounds of this invention can be isolated in association with solvent molecules by crystallization from evaporation of an appropriate solvent. The pharmaceutically acceptable acid addition salts ofthe compounds of formula I, which contain a basic center, maybe prepared in a conventional manner. For example, a solution ofthe free base may be treated with a suitable acid, either neat or in a suitable solution, and the resulting salt isolated either by filtration or by evaporation under vacuum ofthe reaction solvent. Pharmaceutically acceptable base addition salts may be obtained in an analogous manner by treating a solution of compound of formula I with a suitable base. Both types of salt may be formed or interconverted using ion- exchange resin techniques. If the above set out general synthetic methods are not applicable for the obtention of compounds of formula I, suitable methods of preparation known by a person skilled in the art should be used. A final aspect ofthe present invention is related to the formulations contaimng the active compounds according to formula I. When employed as pharmaceuticals, the pyrrolidine derivatives ofthe present invention are typically administered in the form of a pharmaceutical composition. Hence, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable carrier, diluent or excipient therefore are also within the scope of the present invention. A person skilled in the art is aware of a whole variety of such carrier, diluent or excipient compounds suitable to formulate a pharma-ceutical composition. Also, the present invention provides compounds for use as a medi-cament. In particular, the invention provides the compounds of formula I for use as Bax antagonist, for the treatment of disorders of mammals, notably of human beings associated with inappropriate cell death, including neurodegenerative disorders, diseases associated with polyglutamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders, renal hypoxia, hepatitis and AIDS either alone or in combination with other medicaments, notably in combination with further Bax inhibitors. The compounds ofthe invention, together with a conventionally employed adjuvant, carrier, diluent or excipient may be placed into the form of pharmaceutical compositions and unit dosages thereof, and in such form may be employed as solids, such as tablets or filled capsules, or liquids such as solutions, suspensions, emulsions, elixirs, or capsules filled with the same, all for oral use, or in the form of sterile injectable solutions for parenteral administration (including subcutaneous use). Such pharmaceutical compositions and unit dosage forms thereof may comprise ingredients in conventional proportions, with or without additional active compounds or principles, and such unit dosage forms may contain any suitable effective amount ofthe active ingredient commensurate with the intended daily dosage range to be employed. When employed as pharmaceuticals, the pyrrolidine derivatives of this invention are typically administered in the form of a pharmaceutical composition. Such compositions can be prepared in a manner well known in the pharmaceutical art and comprise at least one active compound. Generally, the compounds of this invention are administered in a pharmaceutically effective amount. The amount ofthe compound actually administered will typically be determined by a physician, in the light ofthe relevant circumstances, including the condition to be treated, the chosen route of admimstration, the actual compound administered, the age, weight, and response ofthe individual patient, the severity ofthe patient's symptoms, and the like. The pharmaceutical compositions of these inventions can be administered by a variety of routes including oral, rectal, transdermal, subcutaneous, intravenous, intramuscular, and intranasal. Depending on the intended route of delivery, the compounds are preferably formulated as either injectable or oral compositions. The compositions for oral administration can take the form of bulk liquid solutions or suspensions, or bulk powders. More commonly, however, the compositions are presented in unit dosage forms to facilitate accurate dosing. The term "unit dosage forms" refers to physically discrete units suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical excipient. Typical unit dosage forms include prefilled, premeasured ampoules or syringes ofthe liquid compositions or pills, tablets, capsules or the like in the case of solid compositions. In such compositions, the pyrrolidine compound is usually a minor component (from about 0.1 to about 50% by weight or preferably from about 1 to about 40% by weight) with the remainder being various vehicles or carriers and processing aids helpful for forming the desired dosing form. Liquid forms suitable for oral administration may include a suitable aqueous or nonaqueous vehicle with buffers, suspending and dispensing agents, colorants, tlavors and the like. Solid forms may include, for example, any of the following ingredients, or compounds of a similar nature: a binder such as microcrystalline cellulose, gum tragacanfh or gelatine; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring. Injectable compositions are typically based upon injectable sterile saline or phosphate- buffered saline or other injectable carriers known in the art. As above mentioned, the pyrrolidine compounds of formula I in such compositions is/are typically a minor component, frequently ranging between 0.05 to 10% by weight with the remainder being the injectable carrier and the like. The above described components for orally administered or injectable compositions are merely representative. Further materials as well as processing techniques and the like are set out in Part 8 of Remington 's Pharmaceutical Sciences, 17 th Edition, 1985, Marck Publishing Company, Easton, Pennsylvania, which is incorporated herein be reference. The compounds of this invention can also be administered in sustained release forms or from sustained release drug delivery systems. A description of representative sustained release materials can also be found in the incorporated materials in Remington 's Pharma-ceutical Sciences. In the following the present invention shall be illustrated by means of some examples which are not construed to be viewed as limiting the scope ofthe invention. The HPLC, NMR and MS data provided in the examples described below were obtained as followed. The following abbreviations are hereinafter used in the accompanying examples: min (minute), hr (hour), g (gram), mmol (millimole), m.p. (melting point), eq (equivalents), mL (milliliter), μL (microliters), mL (milliliters), ACN (Acetonitrile), CDC1 3 (deuterated chloroform), cHex (Cyclohexanes), DCM (Dichloromefhane), DECP (Diefhylcyanophosphonate), DIC (Diisopropyl carbodiimide), DMAP (4- Dimethylaminopyridine) DMF (Dimethylformamide), DMSO (Dimethylsulfoxide), DMSO-J 6 (deuterated dimefhylsulfoxide), EDC (l-(3-Dimethyl- amino-propyl)-3-ethylcarbodiimide), EtOAc (Ethyl acetate), Et 2 O (Diethyl ether), HOBt (1- Hydroxybenzotriazole), K 2 CO 3 (potassium carbonate), NaH (Sodium hydride), NaHCO 3 (Sodium bicarbonate), nBuLi (n Butyllifhium), TBTU (O-Benzotriazolyl-N,N,N',N'- tetramethyluronium-tetrafluoroborate), TEA (Triethyl amine), TFA (Trifluoro-acetic acid), THF (Tetrahydrofuran), MgSO 4 (Magnesium sulfate), PetEther (Petroleum ether), rt (room temperature). Examples Intermediate 1: (2S)-l-(tβrt-butoxycarbonyl -4-oxo-2-pyrrolidinecarboxylic acid Commercial (2S,4R)-l-(tert-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic acid (30g, 0.13mol) was dissolved in acetone (1500ml). A mechanical stirrer was placed in the flask and the solution stirred vigorously. A freshly made solution of 8N chromic acid was prepared by dissolving chromium trioxide (66.7g, 0.667mol) in water (40ml), adding concentrated sulphuric acid (53.3ml) and adding enough water to bring the solution volume to 115ml. The 8N chromic acid solution (115ml) was then added dropwise over a period of 30 minutes with continued vigorous stirring, the reaction's exofherm being maintained at the optimal temperature of 25 °C by the use of an ice bath . After the complete addition ofthe chromic acid, the reac-tion mixture was stirred for a further 15 minutes - maintaining the optimal temperature of 25°C. The reaction mixture was then quenched by the addition of methanol (20ml). Exofherm controlled by the use of an ice bath and, if necessary, direct addition of a small amount of crushed ice to the reaction mixture itself. The reaction mixture was filtered through a Celite pad and then concentrated in vacuo. The resulting acidic solution was then extracted with ethyl acetate (3x300ml) and the combined organic layers washed with brine (2x100ml). Organics then dried with magnesium sulfate and concentrated in vacuo. Crude product recrystallised from ethyl acetate to give the white crystalline product, (2S)-l-(tert- butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (22.55g, 76%). The antipodal intermediate, (2R)-l-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid, was made according to the same protocol, starting from commercial (2R,4S)-l-(tert-butoxycarbonyι)-4- hydroxy-2-pyrrolidinecarboxylic acid. IH NMR (360MHz, CDC13); 1.4 (m, 9H), 2.5-3.0 (m, 2H), 3.7-3.9 (m, 2H), 4.75 (dd, IH) Intermediate 2: 1 -tert-butyl 2-methyl (2S)-4-oxo-l,2-pyrrolidinedicarboxylate A solution of (2S)-l-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (lg, 4.3mmol) in a 1:1 mixture of methanol and toluene (60ml) was made. Trimethylsilyl diazomethane (6.5ml of a 2M solution in hexanes, 13mmol) was then added dropwise to the stirred solution at room temperature under nitrogen. After completion ofthe evolution of nitrogen gas, the resulting yellow solution was evaporated in vacuo, and the residue filtered through a pad of silica gel, eluting with ethyl acetate. Removal of solvent from the filtrate gave a yellow oil (1.05g, near quantitative yield). 1H NMR (400 MHz, CDC1 3 ); 1.4 (m, 9H), 2.5 (m, IH), 2.8-2.9 (m, IH) 3.7 (s, 3H), 3.9 (m, 2H), 4.6-4.8 (m, IH). Intermediate 3: 1 -tert-butyl 2-mefhyl (2S,4EZ)-4-(chloromethyleneVl,2-pyrrolidirie- dicarboxylate Chloromethyltriphenylphosphonium iodide (270mg, 0.62mmol) was added to a solution of potassium tert-butoxide (67mg, 0.59mmol) in anhydrous diethyl ether (5ml) under nitrogen and the resulting bright yellow mixture stirred for 30 minutes at ambient temperature. The reaction was then cooled to 0°C and a solution of 1 -tert-butyl 2-methyl (2S)-4-oxo-l,2- pyrrolidinedicarboxylate (lOOmg, 0.41mmol in 2ml anhydrous diethyl ether) was added dropwise. The reaction was then warmed to room temperature and stirred for 30 minutes before adding saturated aqueous ammonium chloride solution (0.5ml). The organic layer was removed in vacuo, and the aqueous washed with diethyl ether (3 x 5ml). The combined organic layers were dried with brine and magnesium sulfate before filtering and removal of solvent. The desired product was isolated by silica gel chromatography, eluting with 15% ethyl acetate in hexanes to give 105mg (93% yield) as a off-white wax. 1H NMR (400 MHz, CDC1 3 ); 1.4 (9H, m), 2.6-2.75 (m, IH), 2.8-3.0 (m, IH), 3.65 (s, 3H), 4.1 (m, 2H), 4.4-4.5 (m, 1H)5.9-6.0 (m, IH). Intermediate 4: 1 -tert-butyl 2-methyl (2S)-4-methylene-l,2-ρyrrolidinedicarboxylate Methyltriphenylphosphonium bromide (22g, 61.6mmol) was added to a solution of potas-sium tert-butoxide (6.5g, 57.6mmol) in anhydrous diethyl ether (450ml) at 0°C under nitrogen and the resulting bright yellow mixture stirred for 30 minutes. A solution of 1 -tert-butyl 2-mefhyl (2S)-4-oxo-l,2-pyrrolidinedicarboxylate (lOg, 41.1 mmol in 150ml anhydrous diethyl ether) was added slowly to the reaction mixture, which was then warmed at 35°C for 3h. Saturated aqueous ammonium chloride solution (0.5ml) was then added. The organic layer was removed, and the aqueous washed with diethyl ether (3 x 5ml). The combined organic layers were dried with brine and magnesium sulfate before filtering and removal of solvent. Silica gel chromatography, eluting with 15% ethyl acetate in hexanes gave the desired pro-duct 6.9g (70% yield) as a off-white wax. 1H NMR (400 MHz, CDC1 3 ); 1.4 (9H, m), 2.5 (m, IH), 2.8 (m, IH), 3.65 (s, 3H), 4.0 (m, 2H), 4.3-4.5 (m, IH), 4.9 (m, 2H). Intermediate 5: 1-tert-butyl 2-methyl (2S,4EZ -4-(cyanomefhylene)- 2-pyrrolidine- dicarboxylate Diethyl cyanomethyl phosphonate (0.86 ml, 4.4mmol) was dissolved in dry THF (50 ml) and the solution cooled to 0°C. Sodium hydride (205mg of a 60% suspension in parrafm oil, 5.1 mmol) was then added cautiously and the reaction stirred for 30 min. The reaction mixture was then cooled to -78°C and a solution of 1-tert-butyl 2-methyl (2S)-4-oxo~l,2- pyrrolidinedicarboxylate (l.Og, 4.1mmol) in dry THF (5ml) was added dropwise. The reaction was then allowed to reach room temperature. Saturated aqueous ammonium chloride solution (15ml) was then added, followed by ethyl acetate (100ml). (The organic layer was removed, and the aqueous washed with ethyl acetate (3 x 5ml). The combined organic layers were dried with brine and magnesium sulfate before filtering and removal of solvent. Silica gel chromatography, eluting with 35% ethyl acetate in hexanes gave the desired compound (860mg, 80%) as an off-white wax. 1H NMR (360 MHz, CDC1 3 ); 1.4 (m, 9H), 2.7-3.0 (m, IH), 3.1-3.3 (m, IH), 3.7 (m, 3H), 4.2- 4.4 (m, 2H), 4.5-4.7 (m, IH), 5.4 (m, IH). Intermediate 6: 1-tert-butyl 2-methyl (2S,4EZ)-4-benzylidene-l,2-pyrrolidinedicarboxylate Potassium tert-butoxide (6.1g, 54mmol) was added portionwise to a solution of benzyl- triphenylphosphonium chloride (22.45 g, 58mmol) in anhydrous dichloromethane (400ml) and the reaction stirred at ambient temperature for lh. The solution was then cooled to 0°C and a solution of 1-tert-butyl 2-methyl (2S)-4-oxo-l,2-pyrrolidinedicarboxylate (9.36g, 38.5mmol) in dry dichloromethane (30ml) was added dropwise. After stirring for a further lh at 0°C the reaction was stirred for a further 3h at ambient temperature. Saturated aqueous ammonium chloride solution (30ml) was then added. The organic layer was removed, and the aqueous washed with dichloromethane (3 x 20ml). The combined organic layers were dried with brine and magnesium sulfate before filtering and removal of solvent. Silica gel chromato-graphy, eluting with 30% ether in hexanes gave the desired product 8.65g (71% yield) as a pale yellow wax. 1H NMR (400 MHz, CDC1 3 );1.5 (m, 9H), 2.8-3.0 (m, IH), 3.2 (m, IH), 3.7 (m, 3H), 4.2-4.4 (m, 2H), 4.5-4.6 (m, IH), 6.3-6.4 (m, IH), 7.1-7.5 (m, 5H). Intermediate 7: (2S,4E2)-l-(tert-butoxycarbonyl -4-(methoxyimino)-2-ρyrrolidinecarboxylic acid A solution was made containing (2S)-l-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (5.0g, 21mmol) and O-methylhydroxylamine hydrochloride (2.7g, 32.8mmol) in chloroform (100ml) containing triefhyl-amine (5.5g, 55mmol). The reaction mixture was then stirred at ambient temperature over-night, prior to removal of solvent. The resultant crude reaction mixture was dissolved in ethyl acetate (150ml) and washed rapidly with IN HCl (40ml). The acidic layer was then extracted with ethyl acetate (3 x 20ml) and the combined organic layers washed with brine before drying over magnesiom sulfate, filtering and removal of solvent in vacuo. The desired product (5.3g, 94%) was isolated as a pale yellow oil. 1H NMR (400 MHz, CDC1 3 ); 1.45 (m, 9H), 2.8-3.2 (m, 2H), 3.9 (s, 3H), 4.2 (m, 2H), 4.5-4.7 (m, IH). Intermediate 8 : (2SAEZ)- 1 -(tert-butoxycarbonyl -4-(ethoxyimino -2-pyrrolidinecarboxylic acid A solution was made containing (2S)-l-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (5.0g, 22mmol) and O-ethylhydroxylamine hydrochloride (6.4g, 65.5mmol) in a 1 :1 mixture of pyridine and ethanol (100ml). The reaction was heated to reflux for 2.5h before cooling and removal of solvent. The residue was dissolved in ethyl acetate and washed rapidly with 1.3N HCl (40ml). The acidic layer was then extracted with ethyl acetate (3 x 20ml) and the combined organic layers washed with brine before drying over magnesiom sulfate, filtering and removal of solvent in vacuo. The desired product (5.5g, 93%) was isolated as a pale yellow oil. 1H NMR (400 MHz, DMSO); 1.3 (t, 3H), 1.55 (m, 9H), 2.9-2.7 (m, IH), 3.4-3.1 (m, IH), 4.1- 4.3 (m, 4H), 4.6 (m, IH), 12-13.5 (br, IH). Intermediate 9 : (2SAEZ)-4- [Call ylox v)imino] - 1 -(tert-butox vcarbonyl)-2-pyrrolidinecarbox ylic acid A solution was made containing (25)- 1 -(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (5.0g, 22mmol) and O-allylhydroxylamine hydrochloride monohydrate (7.2g, 65.5mmol) in a 1:1 mixture of pyridine and ethanol (100ml). The reaction was heated to reflux for 2.5h before cooling and removal of solvent. The residue was dissolved in ethyl acetate and washed rapidly with 1.3N HCl (40ml). The acidic layer was then extracted with ethyl acetate (3 x 20ml) and the combined organic layers washed with brine before drying over magnesium sulfate, filtering and re-moval of solvent in vacuo. The desired product (5.9g, 94%) was isolated as a pale yellow oil. 1H NMR (400 MHz, CDC1 3 ); 1.5 (m, 9H), 2.8-3.2 (m, 2H), 4.2 (m, 2H), 4.5-4.7 (m, 3H), 5.25 (m, 2H), 5.9 ( , IH), 11.1 (broad S, IH). Intermediate 10: l-[(aminooxy)methyl]-4-methoxybenzene A solution was made of Boc hydroxylamine (2.0g, 17.1mmol) in dry THF (60ml). Sodium hydride (l.lg of a 60% suspension in paraffin oil, 25.7mmol) was then added and the suspension stirred. A catalytic amount of KI was then added to the reaction prior to the cautious addition of 4-methoxybenzyl chloride (3.2g, 20.4mmol). The reaction was then allowed to stir overnight before removal of solvent in vacuo. The residue was taken up with diethyl ether (100ml) and HCl gas bubbled in for 20 minutes, causing the start of precipitation ofthe product. The flask was stoppered and left to stand overnight. The product was then filtered off as a off-white wax (39-52% yield according to varying batches). 1H NMR (400 MHz, D 2 O);3.8 (s, 3H), 5 (s, 2H), 7.0 (d, 2H), 7.4 (d, 2H). Intermediate 11: (2S,4EZ)-l-(tert-butoχycarbonyl)-4-{f(4-methoxybenzyl)oxylimino>-2- pyrrolidine-carboxylic acid The same method as employed in the preparation of Intermediate 7, but starting from (2S)-l- (tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (Intermediate 1) and 1- [(aminooxy)methyl]-4-methoxy-benzene (Intermediate 10) gave the title compound as a gum in a 85% yield. 1H NMR (400 MHz, DMSO); 1.5 (m, 9H), 2.7-2.9 (m, IH) 3.9 (s, 3H), 4.2 (m, 3H), 4.6 (m, IH), 5.15 (s, 2H), 7.1 (d, 2H), 7.45 (d, 2H). Intermediate 12: 2-aminoethyl acetate, TFA-salt A solution was made containing ethanolamine (36.5ml, 0.6mol) in chloroform (1000ml). The Boc 2 O (13.1g, 60mmol) dissolved in chloroform (600ml) was slowly added dropwise at 0°C over a 6-hours period (the temperature was maintained all over this period). The reaction was allowed to reach room temperature and was stirred overnight. The organic layer was washed with water (2x500mι), brine and dried over magnesium sulfate before being concentrated in vacuo. The desired product (9.5g, >95%) was isolated as a colourless oil and was used without further purification. A solution was made containing the Boc-ethanolamine (1.92g, 12mmol) with potassium carbonate (5g, 36mmol) in DCM (40ml). Acetyl chloride (30ml, 0.42mol) was added and the reaction stirred for 6 hours at room temperature. The excess of acetyl chloride was removed in vacuo and the crude dissolved in DCM(lOOml). The organic layer was washed with water (50ml), brine and dried over magnesium sulfate before being concentrated in vacuo. The desired product (1.86g, 77%) was isolated as a colourless oil and was used without further purification. A solution was made containing the O-acyl, Boc-ethanolamine (1.65g, 8.1mmol) in DCM (20ml) and TFA (20ml) was added. After one hour at room temperature, the solvent was removed in vacuo. The crude was concentrated from methanol (2-3 times) and from DCM (2-3 times) to give the expected compound (1.75g, quant.) as an oil used without further purification. 1H NMR (400 MHz, D 2 O); 2.0 (m, 9H), 3.1-3.2 (m, 2H), 4.15-4.25 (m, 2H). Intermediate 13: 2'-mefhyl[ 1,1 '-biphenyl] -4-carboxylic acid To a mixture of 4-bromobenzoic acid (30g, 0.15mol), 2-methylphenylboronic acid (24g, 0.15 mol), sodium carbonate (250g) in toluene (500mL) and water (500mL) was added tetrakis- triphenylphosphine palladium(O) (9g, 0.0074mol) under nitrogen atmosphere. The reaction mixture was refluxed for lOh. After this time, 100ml of 10% NaOH were added to the reaction mixture, the aqueous layer was separated and washed with toluene (2x200mL). Acidification ofthe aqueous layer with 3N HCl solution gave a solid product, which was filtered, washed with water and dried. The crude product was then crystallised from toluene to yield 2'- mefhyl[l, -biphenyl]-4-carboxylic acid (20g, 62.5%). Conversely, the product could also be obtained from l-bromo-2-mefhylbenzene and 4-carboxybenzeneboronic acid, using analogous conditions. 1H NMR (300 MHz, DMSO); 2.2 (s, 3H), 7.2-7.4 (m, 4H), 7.43 (d, J = 9Hz, 2H) , 7.99 (d, J = 9Hz, 2H), 13 (b, IH). (in red: no CAS-number) Similarly, using the appropriate commercial boronic acids and arylbromides, the following, related intermediates were obtained: 4'-mefhyl[l,r-biphenyl] -4-carboxylic acid; 2',3- dimethyl[l,l'-biphenyl]-4-carboxylic acid; 2',6'-dimefhyl[l, -biphenyl]-4-carboxylic acid; 2- methyl[l,l'-biphenyl]-4-carboxylic acid; 3 -mefhyl[l,r-biphenyl] -4-carboxylic acid; 2,2'- dimethyl[l,r-biphenyl]-4-carboxylic acid; 2'-methoxy[l,r-biphenyl]-4-carboxylic acid; 3'- methoxy[l,l'-biphenyl] -4-carboxylic acid; 4'-mefhoxy[l, -biphenyl] -4-carboxylic acid; 22- chloro[l,l'-biphenyl]-4-carboxylic acid; 3'-chloro[l,r-biphenyl]-4-carboxylic acid; 4'- chloro[l,l'-biphenyl]-4-carboxylic acid; 3',4'-dichloro[l, -biphenyl]-4-carboxylic acid; 2'- (trifluoromethyl) [1,1 '-biphenyl] -4-carboxylic acid; 3 '-(trifluoromethyl) [1,1 '-biphenyl] -4- carboxylic acid; 2'-cyano[l,l'-biphenyl]-4-carboxylic acid; 2',4'-difluoro[l,r-biphenyl]-4- carboxylic acid; 4-(2-ρyridinyl)benzoic acid; 4-(3-pyridinyl)benzoic acid; 4-(4- pyridinyl)benzoic acid; 4-(5-pyrimidinyl)benzoic acid; and others. Intermediate 14: 4-(3-meτhyl-2-pyridinyl)benzoic acid A mixture of 2-bromo-3-methylpyridine (22.5g, 0.1312mol), 4-(hydroxymefhyl)phenyl- boronic acid (25g, 0.164mol), Pd(PPh 3 ) 4 (9.5g, 0.0082mol), and sodium carbonate (200g in 500 ml of water) in toluene (750 ml) were refluxed under nitrogen atmosphere for 15h. Separated the toluene layer and distilled under reduced pressure to give a residue. The residue was then purified by column chromatography to yield [4-(3-methyl-2- pyridinyl)phenyι]methanol (12g, 47%). To a solution of [4-(3-methyl-2-pyridmyl)phenyl]methanol (12g, O.Oόmol) in dry DMF (150mL) was added pyridiniumdichromate (91g, 0.24mol) and stirred at RT for 3days. The reaction mixture was poured into water and extracted with ethyl acetate (250mL). The organic layer was washed with water, brine, dried and concentrated. The crude was purified by column chromatography over silica gel to give 4-(3-methyl-2-ρyridmyl)benzoic acid (3g, 25%) as white solid. 1H NMR (300 MHz, DMSO); 2.3 (s, 3H), 7.33 (dd, J = 7.5Hz, 5Hz, IH), 7.67 (d, J = 8Hz, 2H) , 7.75 (d, J = 7.5Hz, IH), 8.01 (d, J = 8Hz, 2H), 8.50 (d, J = 5Hz, IH), 13 (b, IH). Intermediate 15: 4-(l-oxido-3-pyridinyl)benzoic acid To a mixture of 4-tolylboronic acid (38g, 0.28mol), 3-bromopyridine (44g, 0.28mol), Na 2 CO 3 (200g) in toluene (500ml) and water (500ml) was added Pd(PPh 3 ) 4 (16g, 0.014mol), and refluxed for 16h. The reaction mixture was cooled, and the separated organic layer was washed with water and brine, and dried. The solvent was removed to give 4-(3-pyridyl)toluene (42g, 90%). To a mixture of 4-(3-ρyridyl)toluene (35g, 0.207mol) in pyridine (400ml) and water (400ml) was added KMnO 4 (163g, 1.03mol) in portions and refluxed for 12h. The reaction mixture was filtered through celite and acidified with cone. HCl. The product was washed with water and dried to give 4-(3-pyridyl)benzoic acid (32g, 76%) as a white solid. To a mixture of 4-(3-pyridyl)benzoic acid (22g, 0.1 lmol) in THF (2.51), mCPBA (152g, 0.44mol, 50%) was added and stirred at RT for 12h. The solid was filtered, and washed with THF to give 4-(l-oxido-3-pyridinyl)benzoic acid (20g, 86%). 1H NMR (300 MHz, DMSO); 7.5-7.8 (m, 5H), 7.9 (d, J = 8Hz, 2H) , 8.33 (d, J = 5Hz, 2H). Similarly, starting from 4-tolylboronic acid (45g, 0.33mol) and 2-bromopyridine (52g, 0.33mol), the related intermediate 4-(l-oxido-2-pyridinyl)benzoic acid was obtained. Example 1: General procedure for the saponification ofthe olefin-type proline methyl esters. such as Intermediates 3-6. A solution of sodium hydroxide (4.5g, 112mmol) in water (70ml) was added to the relevant proline olefin methyl ester (66mmol) in 3:1 dioxane:water (500ml) and the reaction stirred for 3h. The reaction mixture was then washed with diethyl ether (2 x 50ml), and the aqueous phase acidified to pH 2 (0.1N HCl) and extracted into ethyl acetate. The ethyl acetate layer was then dried over magnesium sulfate, filtered and the solvent was then removed in vacuo to give the desired product in near quantitative yields as an oil which was used without further purification. Example 2: General protocol for the solution-phase synthesis of oximether pyrrolidine derivatives of general formula la (Scheme 1): Method A: e.g. (2SAEZ)A-(\1 J'-biphenvn-4-ylcarbonylVN-(2-methoxyethylV4- (mefhoxyimino)-2-pyrrolidinecarboxamide a) Protocol for the formation ofthe amide bond A solution was made containing the central building block, e.g. (2S,4EZ)-l-(tert-butoxycar- bonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid (Intermediate 7) (1.5g, 5.8mmol), an amine or an amine salt, e.g. 2-methoxy-ethylamine (0.51ml, 5.81mmol) and DMAP (780mg, 5.8mmol) in DCM (30 ml). At 0°C, EDC (l.lg, 5.8mmol) was slowly added portion-wise. The reaction was slowly allowed to reach room temperature and was stirred overnight. The DCM was evaporated and the crude purified by column chromatography using EtOAc (100%) to collect the desired product, e.g. tert-butyl (2S,4EZ)-2-{[(2-meth-oxyethyl)amino]carbonyl}-4- (methoxyimino)- 1-pyrrolidinecarboxylate (1.5g, 80%) as a colourless oil. 1H NMR (400 MHz, CDC1 3 ); 1.25 (m, 9H), 2.5-2.9 (m, 2H), 3.1 (s, 3H), 3.2-3.3 (m, 4H), 3.65 (s, 3H), 3.8-4.4 (m, 3H), 6.7 (s broad, IH). b) Protocol for the N-deprotection step A solution was made containing the amide compounds from the previous step, e.g. tert-butyl (2S,4E2)-2- { [(2-methoxyethyl)amino] carbonyl} -4-(mefhoxyimino)- 1 -pyrrolidine-carboxylate (1.5g, 0.4 mmol), in anhydrous ether (35ml). HCl gas was bubbled slowly through the reaction and the deprotection was followed by TLC. After approximately 20 minutes, the ether was evaporated. The product was concentrated in vacuo from DCM (2-3 times) to remove the HCl. The desired product, e.g. (2S,4EZ)-N-(2-methoxyethyl)-4-(methoxyimino)-2-pyrrolidine- carboxamide (1.2g, quant.) was isolated as a yellow oil and used without further purification. c) Protocol for the N-capping step A solution was made containing the free ΝH-compound from the previous step, e.g. (2S,4EZ)- N-(2-methoxyethyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide (940mg, 3.7 mmol), a carboxylic acid, e.g. [l,l'-biphenyl]-4-carboxylic acid (740mg, 3.7mmol) and DMAP (960mg, 7.8mmol) in DCM (30 ml). At 0°C, ΕDC (715mg, 3.7mmol) was slowly added portionwise. The reaction was slowly allowed to reach room temperature and was stirred overnight. The DCM was evaporated and the crude purified by column chromato-graphy using ΕtOAc (100%) to collect the desired product, e.g. (2S,4EZ)-l-([l,l'-biphe-nyl]-4-ylcarbonyl)-N-(2- methoxyethyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide as a mixture of two isomers as an off-white solid. 1H NMR (400 MHz, CDC13); 2.75-2.85 (m, IH), 3.1-3.3 (m, 4H), 3.4-3.5 (m, 4H), 3.8 (m, 3H), 4.1-4.3 (m, 2H), 5.1 (m, IH), 6.9 (m, IH), 7.2-7.7 (m, 10H). M + (APCI + ); 396. Method B: e.g. (2S.4E and 4Z)-N-F(2S)-2-hvdroχy-2-τ>henylethyl]-4-(methoxyimino -l-r(2'- methyir 1 , 1 '-biphenyl]-4-yl carbonyl] -2 -pyrrolidinecarboxamide a) Protocol for the formation ofthe amide bond To a solution ofthe central building block, e.g. (2S,4EZ)-l-(tert-butoxycarbonyl)-4- (methoxyimino)-2-pyrrolidinecarboxylic acid (Intermediate 7) (24.2 mmol, 6.24 g) in dry THF (125 ml) at -25°C was added ΝMM (2.5 eq, 60.4 mmol, 6.64 ml) followed by isobutyl- chloroformate (1.05 eq, 25.4 mmol, 3.3 ml). The resulting mixture was stirred at-25°C for 30 min and an amine or an amine salt, e.g. (S)-2-amino-l-phenylethanol (1.51 eq, 36.5 mmol, 5 g) was then added. The mixture was allowed to gradually warm to rt. After 16h, the solvents were removed. The residue was dissolved in AcOΕt, washed twice with ΝBUC1 saturated solution, then twice with 10% ΝaHCO 3 solution. The organic layer was dried over Na SO , filtrated and concentrated to afford the desired product, e.g. tert-butyl (2S,4EZ)-2-({[(2S)-2- . hydroxy-2-phenylethyl] amino } carbonyl)-4-(mefhoxyimino)- 1 -pyrrolidinecarboxylate (8 ■ .16 g, 96%) as a pale yellow oil in 88.5 % purity by HPLC. 1H NMR (CDC1 3 : 300 MHz) δ 1.44 (s, 9H, N-£oc), 3.23-2.85 (m, 4H), 3.72 (m, IH), 3.85 (s, 3H, O-CH 3 ), 4.10 ( , 2Η), 4.49 ( , IH), 4.83 (m, IH), 7.34 (m, 5H, Ar-H); [M+Na + ] (ΕSf): 400. b) Protocol for the N-deprotection step A solution was made containing the amide compounds from the previous step, e.g. tert-butyl (2S,4E2)-2-({[(2S)-2-hydroxy-2-ρhenylethyl]amino}carbonyl)-4-(methoxyimino)-l- pyrrolidinecarboxylate (2.64 g, 7 mmol), in anhydrous DCM (35 ml). At 0°C, ΗC1 gas was bubbled slowly through the reaction and the deprotection was followed by TLC. After approximately 20 minutes, the DCM was evaporated. The product was concentrated in vacuo from DCM (2-3 times) to remove the ΗC1. The desired product, e.g. (2S,4EZ)-N-[(2S)-2- hydroxy-2-phenylethyl]-4-(methoxyimino)-2 -pyrrolidinecarboxamide (1.94 g, quant.) was isolated as a yellow solid and used without further purification. c) Protocol for the N-capping step To a suspension of 4-(2-methylphenyl)benzoic acid (1.49 g, 7 mmol.) in 35 ml DCM, was added oxalyl chloride and DMF (3 ml) under ice cooling. The mixture was stirred for 2h at rt. The solvent was removed affording the corresponding acyl chloride as a yellow solid. It was dissolved in DCM (30 mL) and added slowly on a 0°C solution containing the free NH- compound from the previous step, e.g. (2S,4E2)-N-[(2S)-2-hydroxy-2-phenylethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (1.94 g, 7 mmol), and triethylamine (5eq, 35 mmol, 4.9 ml) in dry DCM (35 ml). The reaction mixture was stirred overnight at r.t. Pol- trisamine was added (2.12 g, 3.45 mmol g) in order to scavenge excess of acyl chloride. The mixture was shaken 3 h, filtered and the resulting solution was washed with ΝH 4 C1 sat, brine, and dried over Na 2 SO 4 . After filtration and evaporation ofthe solvents, the resulting dark oil (3.26 g) was purified by flash chromatography (Biotage system, column 40M, 90 g SiO2, with gradients of DCM and MeOH as eluent), affording (2S,4EZ)-N-[(2S)-2-hydroxy-2-ρhenyl- ethyl]-4-(methoxyimino)-l-[(2'-mefhyl[l, -biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarbox- amide. Separation ofthe E/Z-isomers was achieved by several chromatographies, affording (2S,4E)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'-biρhenyl]-4- yl)carbonyl]-2-ρyrrolidinecarboxamide (230 mg, colorless powder, 98.7% purity by HPLC) and (2S,42)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (266 mg, colorless powder, 98.3 % purity by HPLC). (2S,4E)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide: M.p. 74°C; IR (neat) v 3318, 2932, 1613, 1538, 1416, 1239, 1047, 848 cm "1 ; 1H ΝMR (300 MHz, CDC1 3 ): 2.27 (s, 3H, ArCH 5 ), 2.89 (dd, J= 6, 12 Ηz, 1Η), 3.18 (br d, J= 12 Ηz, 1Η), 3.27 (m, 1Η), 3.76 (m, 1Η), 3.88 (s, 3Η, ΝOCH 3 ), 4.28 (d, J= 10 Ηz, 1Η), 4.47 (d, J= 10 Ηz, 1Η), 4.59 (br s, 1Η), 4.88 (m, 1Η), 5.20 (m, 1Η), 7.03-7.42 (m, 11Η, Η arom.), 7.45-7.54 (m, 2Η, H arom.); M + (APCI + ): 472; MXAPCf): 470. Analysis calculated for C 28 H 29 N 3 O 4 0.3 H 2 O: C, 70.51 ; H, 6.26; N, 8.81. Found: C, 70.53; H, 6.30; N, 8.87. (2S,4Z)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'-biρhenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide: M.p. 78°C; IR (neat) v 3318, 2938, 1622, 1538, 1416, 1233, 1045, 852 cm "1 ; 1H ΝMR (300 MHz, CDC1 3 ): 2.28 (s, 3H, ArCH ? ), 2.69 (dd, J= 6, 10 Hz, IH), 3.02-3.22 (m, 2H), 3.25 (br s, IH), 3.60 (m, IH), 3.86 (s, 3H, ΝOCH 3 ), 4.14 (m, 2H), 4.71 (m, IH), 4.96 (m, IH), 7.03-7.42 ( , 11H, H arom.), 7.45-7.54 (m, 2H, H arom.); M + (APC ): 472; M " (APCI " ): 470. Analysis calculated for C 28 H 29 N 3 O 4 0.9 H 2 O: C, 68.95; H, 6.36; N, 8.61. Found: C, 68.87; H, 6.25; N, 8.77. d) E/Z-isomerisation The pure E-isomer was isomerized to a mixture ofthe E/Z-isomers by the following procedure: the E-isomer was dissolved in dioxane/water 3:1 mixture. NaOH (1.7 eq; 0.52 mL of NaOH 1.6N) was added and the resulting solution was stirred 2 h at r.t. The mixture was neutralysed with HCl 0.1 N and lyophilised. The components ofthe resulting E/Z-mixture were separated and purified by flash chromatography using same conditions as described above. Example 3 : (2SAEZ)- 1 -fll .1 '-biphenyll-4-ylcarbonyl)-N-[2-(diethylamino ethvn-4- (rf4- methoxybenzyl oxy]imino>-2-pyrrolidinecarboxamide Following the general method as outlined in Example 2, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, [1,1'- biphenyl]-4-carboxylic acid, and Ν^Ν^diethyl-l^-ethanediamine the title compound was obtained after column chromatography as an off-white solid as a mixture of Ε/Z-isomers. IH ΝMR (400 MHz, CDC13); 1.05-1.15 (m, 6H), 2.7-2.8 (m, IH), 2.9-3.2 (m, 6H), 3.4 (m, IH), 3.6 (s, 3H), 4.0-4.1 (m, IH), 4.3-4.4 (m, IH), 3.75 (m, IH), 3.8 (m, 2H), 6.65 (m, 2H), 7.0-7.1 (m, 2H), 7.2-7.3 (m, 3H), 7.35-7.45 (m, 6H), 8.8 (s/br, 0.5H). M + (APCI + ); 543. Examρle 4: (2S,4EZ)-l-(riJ'-biρhenyl]-4-ylcarbonyl)-4-( ' chloromethylene -N-rf2RS -2- hydroxy-2-phenethyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 2, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4- carboxylic acid, and (lRS)-2-amino-l-phenylethanol, the title compound was obtained after column chromatography as a mixture of Ε/Z-isomers as an off-white solid. The two isomers could be separated by another flash chromatographic purification step. (2S,4E)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-[(2RS)-2-hydroxy-2- phenethyl]-2-ρyrrolidinecarboxamide: IH ΝMR (400 MHz, CDC13); 2.6-2.7 (m, IH), 2.8-3.0 (m, 3H), 3.2 ( , IH), 3.4-3.6 (m, IH), 3.9 (m, IH), 4.15 (t, IH), 4.6 (m, IH), 4.85 (m, IH), 5.75 (s, IH), 7.0-7.4 (m, 14H). M + (APCI + ); 461. (2S,4Z)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-(chloromefhylene)-N-[(2RS)-2-hydroxy-2- phenefhyl]-2-pyrrolidinecarboxamide: IH ΝMR (400 MHz, CDC13); 2.5-2.6 (m, IH), 2.7-2.9 (m, IH), 3.0 (m, IH), 3.1-3.4 (m, IH), 3.4-3.6 (m, IH), 3.9-4.0 (m, IH), 4.2-4.4 (m, 2H), 4.6 (m, IH), 4.8-4.9 (m, IH), 5.75 (s, IH), 7.0-7.5 (m, 14H). M^APCf); 461. Example 5 : (2S,4EZ)-N-[2-(diethylamino)ethyl]- 1 -(diphenylacetyl -4-( ' methoxyimino -2- pyrrolidinecarboxamide Following the general method as outlined in Example 2, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetic acid, and Ν 1 ,Ν ! -diethyl- 1 ,2-ethanediamine the title compound was obtained after column chromatography as an off-white solid as a mixture of Ε/Z-isomers. IH ΝMR (400 MHz, CDC13); 0.9 (t, 3H), 1.0 (m, 3H), 2.6-3.1 (m, 7H), 3.15 (m, IH), 3.4 (m, IH), 3.75 (s, 3H), 3.95 (t, IH), 4.4-4.7 (m, 4H), 5.1 (m, IH), 7.0-7.3 (m, 10H), 9.1 (m, IH). M + (APC ); 451. Example 6: (2S,4EZ)-4-(ethoxyimino)-N-(9-ethyl-9H-carbazol-3-yl)-l -rphenoxyacetyl -2- pyrrolidinecarboxamide Following the general method as outlined in Example 2, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, phenoxyacetic acid, and 9- ethyl-9H-carbazol-3 -amine the title compound was obtained after column chromatography as an off-white solid as a mixture of Ε/Z-isomers. The isomers were then separated using column chromatography. (2S,4E)-4-(ethoxyimino)-N-(9-ethyl-9H-carbazol-3-yl)-l-(phenoxyacetyl)-2-pyrrolidine- carboxamide: 1Η ΝMR (360MΗz, CDC1 3 ); 1.2 (m, 6H), 2.7 (m, IH), 3.35 (d, IH), 4.1 (m, 4H), 4.3 (d, IH), 4.45 (d, IH), 4.7 (m, 2H), 5.15 (d, IH), 6.9-7.3 (m, 10H), 7.9 (d, IH), 8.15 (m, IH), 9.0 (br s, IH). M^APC ); 499. (2S,4Z)-4-(ethoxyimino)-N-(9-ethyl-9H-carbazol-3 -yl)- 1 -(phenoxyacetyl)-2-pyrrolidine- carboxamide: IH ΝMR (360MHz, CDC1 3 ); 1.2 (m, 6H), 2.7 (m, IH), 3.2 (m, IH), 4.1 (m, 4H), 4.35 (m, 2H), 4.7 (m, 2H), 5.1 (m, IH), 6.9-7.3 (m, 10H), 7.9 (d, IH), 8.15 (m, IH), 9.0 (br s, IH). M + (APCI + ); 499. Example 7: (2S.4EZ)-N-(9-eτhyl-9H-carbazol-3-ylV4-(methoxyiminoVl-r(2-oxo-6-pentyl-2H- pyran-3 - ypcarbon yl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 2, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3 - carboxylic acid, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained after column chromatography as an off-white solid as a mixture of Ε/Z-isomers. The isomers were separated by column chromatography. (2S,4E)-N-(9-ethyl-9H-carbazol-3-yl)-4-(methoxyimino)-l-[(2-oxo-6-ρentyl-2H-pyran-3- yl)carbonyl]-2-pyrrolidinecarboxamide: IH ΝMR (360MHz, CDC1 3 ); 0.8 (m, 6H), 1.2 (m. 6H), 2.5 (m, 2H), 3.0 (m, IH), 3.3 (m, IH), 3.8 (s, 3H), 4.2 (m, 3H), 4.45 (m, IH), 5.3 (m, IH), 6.1 (d, IH), 7.1 (m, IH), 7.2 (m, IH), 7.3 (d, IH), 7.35 (m, 1.H), 7.55 (m, IH), 7.65 (m, IH), 8.0 (d, IH), 8.5 (m, IH), 9.1 (br S, IH). M + (ΕS + ); 543. (2S,4Z)-N-(9-ethyl-9H-carbazol-3-yl)-4-(methoxyimino)-l-[(2-oxo-6-pentyl-2H-pyran-3- yl)carbonyl]-2-pyrrolidinecarboxamide: IH ΝMR (360MHz, CDC1 3 ); 0.8 (m, 6H), 1.2 (m. 6H), 2.5 (m, 2H), 3.05 (m, IH), 3.25 (m, IH), 3.75 (s, 3H), 4.1 (m, 3H), 4.45 (d, IH), 5.3 (d, IH), 6.1 (d, IH), 7.1 (t, IH), 7.2 (m, IH), 7.3 (m, IH), 7.4 (m, IH), 7.6 (m, IH), 7.7 (m, IH), 8.0 (d, IH), 8.45 (m, IH), 9.1 (m, IH). M + (ES + ); 543. Example 8 : (2SAEZ)-4- f allylox v)iminol- 1 -benzoyl-N-(9-ethyl-9H-carbazol-3-yl)-2- pyrrolidinecarboxamide Following the general method as outlined in Example 2, starting from (2S,4EZ)-4-[(allyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-ρyrrolidinecarboxylic acid, benzoic acid, and 9-efhyl- 9H-carbazol-3 -amine the title compound was obtained after column chromatography as an off- white solid as a mixture of Ε/Z-isomers. IH ΝMR (360MHz, CDC1 3 ); 1.2 (m, 3H), 2.8 (m, IH), 3.35 (m, IH), 4.2 (m, 4H), 4.4 (m, 3H), 5.2 (m, 2H), 5.35 (m, IH), 5.85 (m, IH), 7.0-7.5 (m, 5H), 7.9 (m, 3H), 8.1 (m, 2H), 8.3 ( , IH), 9.2 (br s, IH). M + (APCI + ); 481. Example 9: General protocol for the solution-phase synthesis of oximether pyrrolidine derivatives of general formula I containing additional reactive groups: (2S,4EZ)-1-([1 '- biphenvn-4-ylcarbonyl -N-(2-hydroxyethyl -4-(methoxyimino -2-pyrrolidinecarboxamide a) Protocol for the formation ofthe amide bond A solution was made containing the central building block, e.g. (2S,4EZ)-l-(tert-butoxycar- bonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid (Intermediate 7) (575mg, 2.2mmol), the amine or amine salt containing the suitably protected reactive group, e.g. 2-aminoethyl acetate (Intermediate 12) (480mg, 2.2mmol) and DMAP (870mg, 7.1mmol) in DCM (20 ml). At 0°C, ΕDC (427mg, 2.2mmol) was slowly added portion-wise. The reaction was slowly allowed to reach room temperature and was stirred overnight. The DCM was evaporated and the crude purified by column chromatography using ΕtOAc/Hexane: 55/45 to collect the desired amide compound, e.g. tert-butyl (2S,4EZ)-2-({[2-(acetyloxy)ethyl]-amino}carbonyl)- 4-(methoxyimino)-l-pyrrolidinecarboxylate (373mg, 49%) as an oil. IH NMR (400 MHz, CDC13); 1.7 (m, 9H), 2.1-2.2 (m, 3H), 2.8-3.3 (m, 2H), 3.7-3.8 (m, 2H), 4.0-4.1 (m, 3H), 4.2-4.8 (m, 5H), 7.3 (s broad, IH). b) Protocol for the N-deprotection step A solution was made containing the Boc-protected compound from the previous step, e.g. tert- butyl (2S,4EZ)-2-({[2-(acetyloxy)ethyl] amino} carbonyl)-4-(methoxyimino)-l -pyrroli- dinecarboxylate (373mg, 1.2mmol) in anhydrous ether (40ml). HCl gas was bubbled slowly through the reaction and the deprotection was followed by TLC. After approximately 20 minutes, the ether was evaporated. The product was concentrated in vacuo from DCM (2-3 times) to remove the HCl. The desired free NH product, e.g. 2-({[(2S,4EZ)-4-(methoxy- imino)pyrrolidinyl]carbonyl}amino)ethyl acetate (300mg, quant.) was isolated as a yellow oil and used without further purification. IH NMR (400 MHz, D 2 O); 1.75 (s, 3H), 2.55-2.65 (m, IH), 2.8-3.3 (m, 3H), 3.45-3.55 (m, 3H), 3.8-4.0 (m, 4H), 4.25-4.35 (m, IH). c) Protocol for the N-capping step A solution was made containing the amine-hydrochloride from the previous step, e.g. 2- ({[(2S,4EZ)-4-(methoxyimino)pyrrolidinyl]carbonyl}amino)ethyl acetate (560mg, 2mmol) and an acid chloride, e.g. [l,l'-biphenyl]-4-carbonyl chloride (433mg, 2mmol) in DCM (20ml). Triethylamine (0.7ml, 5mmol) was added and the reaction stirred overnight at room temperature. The DCM was evaporated and the crude purified by column chromatography using ΕtOAc (100%) to collect the desired amide compound, e.g. 2-({[(2S,4EZ)-l-([l,l'- biphenyl]-4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl]carbonyl} amino)ethyl acetate (457mg, 54%) as an oil. IH NMR (400 MHz, CDC13); 1.9 (s, 3H), 2.7-2.8 (m, IH), 3.2-3.6 (m, 3H), 3.75-3.85 (m, 3H), 4.0-4.4 (m, 4H), 5.15-5.25 (m, IH), 7.2-7.6 (m, 9H). d) Protocol for the deprotection ofthe reactive group A solution was made containing the side-chain protected compound from the previous step, e.g. 2-({[(2S,4EZ)-l-([l, -biphenyl]-4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl] carbonyl} amino)ethyl acetate (450mg, 10.6mmol) in THF (10ml). An aqueous solution (10ml) of sodium hydroxide (75mg, 19mmol) with methanol (5ml) was added and the reaction stirred at room temperature for three hours. The solvent was removed in vacuo and the crude purified by column chromatography using THF (100%) to give the expected final product, e.g. (2S,4EZ)- 1 -([1 , 1 '-biphenyl]-4-ylcarbonyl)-N-(2-hydroxyethyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (300mg, 75%) as a white solid. IH ΝMR (400 MHz, CDC13); 2.85-3.0 (m, IH), 3.3-3.6 (m, 3H), 3.7-3.8 (2H), 3.85-3.95 (m, 3H), 4.2-4.5 (m, 2H), 5.15-5.25 (m, IH), 7.2-7.9 (m, 9H). M^APCI*); 382. Example 10: (2S.4EZ)-1-([1 J'-biphenyll-4-ylcarbonylVN-r(2RS)-2-hvdroxy-2-phenethyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide Following the general method as' outlined in Example 9, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [l, -biphenyl]-4-carbonyl chloride, and 2-amino-l-ρhenylethyl acetate, the title compound was obtained after column chromatography as a mixture of E/Z-isomers as an off-white solid. The two isomers could be separated by another flash chromatographic purification step. (2S,4E)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide: IH ΝMR (400 MHz, CDC13); 2.75-2.9 (m, IH), 3.1-3.25 (m, 2H), 3.35-3.6 (m, IH), 3.7-3.8 (m, IH), 3.75 (s, 3H), 4.1-4.3 (m, 2H), 4.8 (m, IH), 5.1 (dd, IH), 7.1-7.6 (m, 15H). M^APCf); 458. (2S,4Z)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenethyl]-4- (mefhoxyimino)-2-pyrrolidinecarboxamide: IH ΝMR (400 MHz, CDC13); 2.7-2.85 (m, IH), 3.05-3.25 (m, 2H), 3.35 (m, IH), 3.65-3.8 (m, IH), 3.8 (s, 3H), 4.15-4.25 (d, IH), 4.25-4.4 (m, IH), 4.75 (m, IH), 5.1 (dd, IH), 7.15-7.6 (m, 15H). M + (APCI + ); 458. Example 11 : General protocol for the solution-phase synthesis of oximether pyrrolidine derivatives of general formula lb ( " Scheme 5 ; (3EZ,5S)-5-(lH-be:nzimidazol-2-yr)-l-([ r- biphenyl]-4-ylcarbonviy3-pyffolidinone O-methyloxime a) Protocol for the formation ofthe amide bond A solution was prepared contaimng the central building block, e.g. (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid (Intermediate 7) (2.1g, 8.1mmol), an ortho-substituted aromatic amine or amine salt, e.g. 1,2-benzenediamine (0.88g, 8.1mmol) and DMAP (1.59g, 13.0mmol). in dry dichloromethane (30ml). This solution was cooled to 0°C and treated with ΕDC (1.56g, 8.2mmol) before warming to room temperature and stirring for 2 days. The solvent was removed in vacuo and the product purified by silica gel chromatography, eluting with a gradient of 30-80% ethyl acetate in hexane to give the desired anilide product, e.g. tert-butyl (2S,4EZ)-2-[(2-aminoanilino)carbonyl]-4- (methoxyimino)-l-pyrrolidinecarboxylate 2.8g, 97% as a colourless foam. IH NMR (360MHz, CDC13); 1.7, (m, 9H), 2.5-3.5 (br, 4H), 3.4 ( , IH), 4.0 (m, 3H), 4.2-4.4 (m, 2H), 4.9 (m, IH), 6.9-7.5 (m, 4H), 8.5 (br, IH). b) Protocol for the formation of the fused heterocyclic ring A solution ofthe anilide compound from the previous step, e.g. tert-butyl (2S,4EZ)-2-[(2- aminoanilino)carbonyl]-4-(methoxyimino)-l-pyπOlidinecarboxylate (0.8g, 2.3mmol) in dichloromethane (30ml) and acetic acid (3ml) was stirred at room temperature for 3 days. Saturated aqueous sodium bicarbonate (7ml) was added to the reaction, the organic phase collected and dried over magnesium sulfate before filtering and removal of solvent in vacuo to give the desired product, e.g. tert-butyl (2S,4EZ)-2-(lH-benzimidazol-2-yl)-4-(methoxy- imino)-l-pyrrolidinecarboxylate (740mg, 97%) as an off-white foam. 1Η NMR (360MHz, CDC13); 1.5 (m, 9H), 3.1 (m, IH), 3.8 (m, 3H) 3.9-4.3 (m, 3H), 5.3 (m, IH), 7.1-7.6 (m, 4H), 10-10.5 (br, IH). c) Protocol for the N-deprotection step Hydrogen chloride gas was bubbled into a solution ofthe fused heterocyclic product from the previous step, e.g. tert-butyl (2S,4EZ)-2-(lH-benzimidazol-2-yl)-4-(mefhoxyimino)-l- pyrrolidinecarboxylate (740mg, 2.2mmoι) in dry DCM (20ml) for 30 min.. The solvent was removed in vacuo to give the desired product, e.g. (3EZ,5S)-5-(lH-benzimidazol-2-yl)-3- pyπolidinone O-methyloxime (0.58g, 99%), as a brown amorphous powder which was used without further purification. d) Protocol for the N-capping step A solution ofthe free NH product from the previous step, e.g. (3EZ,5S)-5-(lH-benzimida-zol- 2-yl)-3 -pyrrolidinone O-methyloxime (0.58g, 2.2mmol) in dry dichloromethane (25ml) was treated with an acid chloride, e.g. [l,l'-biphenyl]-4-carbonyl chloride (0.48g, 2.2mmol) and triethylamine (0.9ml, 6.6mmol). The resulting solution was then stirred for 3h at room temp before removal of solvent in vacuo and the desired isomers were isolated by flash chromatography on silica gel, eluting with a gradient of ethyl acetate (10-80%) in hexane to give the two isomers (120mg ofthe less polar and 400mg ofthe more polar) ofthe desired product, e.g. (3E,5S)- and (3Z,5S)-5-(lH-benzimidazol-2-yl)-l-([l,l'-biphenyl]-4-ylcarbo- nyl)-3 -pyrrolidinone O-methyloxime, as off-white powders. (3E,5S)-5-(lH-benzimidazol-2-yl)-l -([1,1 '-biphenyl]-4-ylcarbonyl)-3-pyrrolidinone O- methyloxime: 1H NMR (360MHz, CDC13); 3.2, (m, IH), 3.8 (s, 3H), 4.0 (m, IH), 4.3 (m, 2H), 6.0 (m, IH), 6.0 (m, IH), 7.2-7.7 (m, 13H), 10-11 (br, IH). M + fAPCi 4 ); 411. (3Z,5S)-5-(lH-benzimidazol-2-yl)-l-([l,r-biphenyl]-4-ylcarbonyl)-3-pyrrolidinone O- mefhyloxime: IH NMR (360MHz, CDC13); 3.1, (m, IH), 3.8 (s, 3H), 3.9 (m, IH), 4.3 (m, 2H), 6.0 (m, IH), 6.0 (m, IH), 7.2-7.7 (m, 13H), 10-11 (br, IH). M + (APCfj; 411. Example 12: (3EZ5S)-5-(lH-benzimidazol-2-yl -l-r(2 , -methyl[Lr-biphenyll-4-vncarbonyll- 3-pyrrolidinone O-methyloxime Following the general method as outlined in Example 11 , starting from (2S,4EZ)-1 -(tert- butoxycarbonyl)-4-(methoxyimino)-2-ρyrrolidinecarboxylic acid, 2'-methyl[l ,1 '-biphenyl]-4- carboxylic acid, and 1,2-benzenediamine, the title compound was obtained in 91% purity by HPLC. MS(ESI+): m/z = 425. Example 13 : (3E 5S)-5-(l-methyl-lH-benzimidazol-2-vn-l-r(2'-methyl[ r-biphenvn-4- yDcarbonyl] -3-pyrrolidinone O-methyloxime Following the general method as outlined in Example 11, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[ 1 , 1 '-biphenyl]-4- carboxylic acid, and N 1 -methyl- 1,2 -benzenediamine, the title compound was obtained in 83% purity by HPLC. MS(ΕSI+): m/z = 439. Example 14: (3EZ5S)-5-(7-hvdroxy-lH-benzimidazol-2-yl)-l-rr2'-methyl lJ'-biphenyll-4- yl carbonyl]-3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 11, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[ 1 , 1 '-biphenyl] -4- carboxylic acid, and 2,3-diaminophenol, the title compound was obtained in 91% purity by HPLC. MS(ΕSI+): m/z - 441. Example 15: (3EZ.5S)-5-(3.4-dihvdro-2-quinazolinyl -l-[(2'-methvir l'-biphenyl1-4- vDcarbonyl] -3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 11, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pyrrolidinecarboxylic acid, 2'-mefhyl[ 1 , 1 '-biphenyl]-4- carboxylic acid, and 2-(aminomethyl)aniline, the title compound was obtained in 77% purity by HPLC. MS(ΕSI+): m z = 439. Example 16: (3EZ,5S)-l-( l'-biρhenyll-4-ylcarbonylV5-(l-methyl-lH-benzimidazol-2-yl -3- pyrrolidinone O-methyloxime Following the general method as outlined in Example 11, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyπolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and N 1 -methyl- 1,2-benzenediamine, the title compound was obtained in 88% purity by HPLC. MS(ESI+): m/z = 425. Example 17: General protocol for the solution-phase synthesis of oxime or hydrazone pyrrolidine derivatives of general formula I (Scheme 6); (2S, 4EZ)-l-( U'-biρhenyl]-4- ylcarbonyl -4-(hvdroχyimino)-N-[(2RS)-2-hvdroxy-2-phenethyl -2-pyrrolidinecarboxamide. a) Protocol for the hydrolysis ofthe oximether group. The starting oximether compounds, e.g. (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)- 2-hydroxy-2-phenethyl] -4-(methoxyimino)-2-pyπolidinecarboxamide, were obtained following the general methods as outlined, e.g., in Example 2, 11 or 22. A solution was made containing the oximether compound, e.g. (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)- 2-hydroxy-2-phenethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (64 mg, 0.14 mmol), paraformaldehyde powder (95%, 42 mg, 1.41 mmol) and Amberlyst 15 (30 mg) in acetone containing 10% of water (2 mL). The reaction was stirred 4 h at 60°C. Insoluble materials were filtered off and washed with a small amount of acetone. The filtrate was concentrated and the residue was diluted with DCM (15 mL). The organic solution was washed with brine (10 mL), dried overΝa2SO , and concentrated. The desired ketocarbonyl product, e.g. (2S)-1- ([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-4-oxo-2- pyrrolidinecarboxamide (56 mg, 92%) was isolated as a yellow oil and used without further purification. b) Protocol for the formation of oxime and/or hydrazone compounds A solution was made containing the keto-pyrrolidine derivative from the previous step, e.g. (2S)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenethyl]-4-oxo-2- pyrrolidinecar-boxamide (46 mg, 0.11 mmol) and hydroxylamine hydrochloride (12 mg, 0.17 mmol) in chloroform (1 ml) containing triethylamine (29 mg, 0.29 mmol). The reaction mixture was then stirred at ambient temperature for one day, prior to removal of solvent. The resultant crude reaction mixture was purified by column chromatography using DCM/MeOH (25:1) to collect the desired product, e.g. (2S, 4EZ)-1 -([1,1 -biphenyl] -4-ylcarbonyl)-4- (hydroxy-imino)-N-[(2RS)-2-hydroxy-2-ρhenethyl]-2-pyπolidinecarboxamide as a mixture of two isomers as an off-white solid (46 mg, 96% yield). 1H ΝMR (300 MHz, CDC1 3 ); 2.6-3.3 (m, 4H), 4.0-4.7 (m, 4H), 4.9 (m, IH), 5.5 (m, IH), 7.1- 7.5 (m, 8H), 7.6-7.8 (m, 5H), 8.1 (m, IH), 10.9 (m, IH). M^APC ); 444. Example 18: (2S.4EZ)-l-rria'-biphenyl]-4-ylcarbonyl)-4-(dimethylhvdrazono)-N-r(2RS -2- hydroxy-2-phenylethyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 17, starting from (2S)-1-([1,1'- biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-oxo-2-pyrrolidinecarboxamide and NN-dimethylhydrazine, the resultant crude reaction mixture was purified by column chromatography using DCM/MeOH (30:1) to collect the desired product, e.g. (2S,4EZ)-1- ([l,r-biphenyl]-4-ylcarbonyl)-4-(dimethylhydrazono)-N-[(2RS)-2-hydroxy-2-phenylethyl]-2- pyrrolidinecarboxamide as a mixture of two isomers as a light yellow oil in 56% yield (90.2 % purity by HPLC). 1H ΝMR (300 MHz, CDC1 3 ); 2.35-2.55 (br s, 3H), 2.40-2.60 (m, IH), 2.75-3.55 (m, 5H), 3.55-3.82 (m, IH), 3.90-4.4 (m, 2H), 4.83 (m, IH), 4.93-5.35 (m, IH), 7.18-7.49 (m, 9H), 7.49-7.68 (m, 5H). M + (APCI + ); 471. M " (APCT); 469. Example 19: (2S.4EZ -l-fri.l'-biρhenyl1-4-ylcarbonyl -N-r(2RS)-2-hvdroxy-2-phenylethyll-4- (methylhvdrazono -2-pyrrolidinecarboxamide Following the general method as outlined in Example 17, starting from (2S)-1-([1,V- biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-oxo-2-pyrrolidinecarboxamide and N-methylhydrazine, the resultant crude reaction mixture was purified by column chromatography using DCM/MeOH (30:1) to collect the desired product, e.g. (2S,4EZ)-1- ([l,r-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methylhydrazono)-2- pyrrolidinecarboxamide as a mixture of two isomers as a colorless solid in 57% yield (95.2 % purity by HPLC). 1H NMR (300 MHz, CDC1 3 ); 2.45-2.70 (m, IH), 2.85 (br s, 3H, NNHCHj), 2.85-3.5 (m, 2H), 3.51-4.4 (m, 4H), 4.84 (br s, lH, NNHMe), 4.95-5.35 (m, 1Η), 7.18-7.67 (m, 14Η). M^APC ); 457. M " (APCI " ); 455. Example 20: (2S,4EZ)-l-([ l'-biphenyl1-4-ylcarbonylV4-hydrazono-N-[(2RS)-2-hvdroχy-2- phenylethyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 17, starting from (2S)-1-([1,1'- biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-oxo-2--pyrrolidinecarboxamide and hydrazine hydrate (4% in EtOH), the resultant crude reaction mixture was purified by column chromatography using DCM/MeOH (30:1) to collect the desired product, e.g. (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-hydrazono-N-[(2RS)-2-hydroxy-2-phenylethyl]-2- pyrrolidinecarboxamide as a mixture of two isomers as a colorless solid in 63% yield (95.3 % purity by HPLC). 1H ΝMR (300 MHz, DMSO- , 80°C); 2.55 (dd, J= 9.8; 17.6 Hz, IH), 2.73 (dd, J= 9.8; 18.2 Hz, IH), 3.28 (m, 2H), 4.12 (m, 2H), 4.61 (m, IH), 4.85 (m, IH), 5.15 (m, IH), 5.70 (br s, 2H, ΝH 2 Ν=C), 7.17-7.43 (m, 6H), 7.44-7.60 (m, 4H), 7.66-7.77 (m, 5H). M + (APCI + ); 443. M " (APCr); 441. Example 21 : (2S.4EZ)-4-(acetylhvdrazono -l-(T r-biphenvn-4-ylcarbonvn-N-[(2RS)-2- hvdroxy-2-phenylethyl]-2-pyπolidinecarboxamide A hydrazono pyrrolidine derivative obtained by the general method outlined in Example 17, e.g. (2S,4EZ)-1 -([1 ,l'-biρhenyl]-4-ylcarbonyl)-4-hydrazono-N-[(2RS)-2-hydroxy-2- phenylethyl]-2-pyrrolidinecarboxamide (51 mg, 0.11 mmol) was dissolved in pyridine (1 mL). Acetic anhydride (3 eq, 32 μl, 0.35 mmol) was added, and the mixture was stirred overnight. The solvent was evaporated and the resultant crude reaction mixture was purified by column chromatography using DCM/MeOH (20:1) to collect the desired product, e.g. (2S,4EZ)-4- (acetylhydrazono)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-2- pyrrolidinecarboxamide as a mixture of two isomers as a colorless solid in 73% yield (98.4 % purity by HPLC). 1H NMR (300 MHz, ΩMSO-d 6 , 80°C); 1.99 (br s, 3H, CH 3 CON), 2.1-3 A (m, 5H), 4.26 (m, 2H), 4.63 (m, IH), 4.89 (m, IH), 5.15 (m, IH), 7.18-7.44 (m, 6H), 7.45-7.62 (m, 4H), 7.66- 7.85 (m, 5H), 9.97 (br s, IH, MeCONHN, major isomer), 10.04 (br s, 1Η, MeCONHN, minor isomer). M^S ); 485. M " (ESI " ); 483. Example 22: General protocol for the solid-phase synthesis of pyπolidine derivatives of general formula I. a) Loading step Kaiser oxime resin (16.5g, loading 1.57mmol/g) was added to a solution ofthe relevant pyrrolidine carboxylic acid building block (51.8mmol) and diisopropylcarbodiimide (8.1ml, 51.8mmol) in dry dichloromethane (150ml). The resulting suspension was shaken over-night before filtering at the pump and washing sequentially with DMF, DCM and finally diethyl ether before drying at room temperature in vacuo. b) N-deprotection step The resin obtained in the loading step was shaken with a 20% solution of trifluoroacetic acid in dichloromethane (200ml) for 30 minutes prior to filtering at the pump and washing sequentially with aliquots of DMF, DCM and finally diethyl ether before drying at room temperature in vacuo. c) N-capping step The resin from the previous step was transfeπed into a 96-well filter-plate (approx. 50mg of dry resin/well) and each well treated with an N-reactive derivatising agent, e.g. with either of the following solutions: a) an acid chloride (0.165mmol) and diisopropylethylamine (0.165mmol) in dry dichloromethane (1ml), overnight b) an acid (0.165mmol) and DIC (0.165mmol) in, depending on the solubility ofthe car- boxylic acid, dry dichloromethane or ΝMP (1 ml) overnight. c) an isocyanate (0.165mmol) in dry THF (1ml), overnight d) a sulfonyl chloride (0.165mmol) and diisopropylethylamine (0.165mmol) in NMP (1ml), overnight. e) a benzyl (alkyl) bromide (0.165mmol) and diisopropylethylamine (0.165mmol) in NMP (1ml), overnight. f) a vinyl ketone (0.165mmol) in THF, overnight g) diketene (0.165mmol) in THF, overnight The plate was then sealed and shaken overnight at ambient temperature. The resins were then filtered, washing the resin sequentially with aliquots of DMF, DCM and finally diethyl ether before drying at room temperature in vacuo. d) Cleavage step A solution of amine (O.OSmmol) in 2% AcOH in dichloromethane (1ml) was added to each well containing the resin from the previous step. The plate was then sealed and shaken for two days at ambient temperature. The wells were then filtered into a collection plate and the solvent removed in a vacuum centrifuge to yield 2-3 mg ofthe corresponding products, generally obtained as oils. The products were characterised by LC (205nm) and mass spec- trometry (ES+). All ofthe following examples were identified based on the observation ofthe coπect molecular ion in the mass spectrum, and were shown to be at least 40% pure (usually 60-95% pure) by LC. Example 23: (2S,4EZ)-N 2 -(2-hvdroχyethyl -4-rmethoχyimino -N 1 -pentyl-1.2-pyrrolidine- dicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(/ert-but- oxycarbonyl)-4-(mefhoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 2- aminoethanol the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 315.2. Example 24 (2S.4EZ)-4-benzylidene- 1 -ff 1.1 '-biphenyl]-4-ylcarbonyl)-N-r2-(diethylamino)- ethyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzy- lidene- 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, [1,1' -biphenyl] -4-carbonyl chloride, and Νl ,Ν1 -diethyl- 1 ,2-ethanediamine the title compound was obtained in 90% purity by LC/MS. MS(ΕSI+): m/z = 482.4. Example 25: ( " 2S.4EZ -4-[(allyloxy)imino1-l-(4-cvanobenzoylVN-r2-( ' lH-ρvπol-l-yl)ρhenyl1- 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 2-(lΗ-pyrrol-l-yl)phenylamine the title compound was obtained in 51% purity by LC/MS. MS(ΕSI+): m/z = 454.4. Example 26: (2S.4EZ -4-{ r3.4-dichlorobenzvnoxy1imino -N-r2-furylmethvn-l-r(2-oxo-6- pentyl-2H-pyran-3-yl carbonyl1-2-pyπolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 2-oxo-6- pentyl-2Η-pyran-3-carbonyl chloride, and 2-furylmethylamine the title compound was obtained in 92% purity by LC/MS. MS(ΕSI+): m z = 574.4. Example 27: (2S,4EZ)-4-rmethoxyiminoVN 1 -( ' 3-methoxyphenyl)-N 2 -(2-thienylmethyl - 12- pyrrolidinedi carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1 -isocyanato-3-methoxy- benzene, and 2-thienylmethylamine the title compound was obtained in 79% purity by LC/MS. MS(ΕSI+): m z = 403.2. Example 28: f2S.4EZ)-2-{r4-(1.3-benzodioxol-5-ylmethyl -l-ρiperazinyl]carbonyl}-4- (methoxyimino)-N-pentyl- 1 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 1- (1 ,3-benzodioxol-5-ylmethyl)piperazine the title compound was obtained in 72% purity by LC/MS. MS(ΕSI+): m/z = 474.4. Example 29: (2S.4EZ)-4-r(benzyloxy iminol- 1 -(4-cvanobenzoyl)-N-(2-furylmethyl -2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 2-furylmethylamine the title compound was obtained in 49% purity by LC/MS. MS(ΕSI+): m/z = 443.4. Example 30: (2S,4EZ)-4-[(benzyloxy imino]-N-[2-(diethylamino)ethyl]-l-(4-phenoxyben- zoyl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and Ν1,Ν1 -diethyl- 1,2-ethanediamine the title compound was obtained in 86% purity by LC/MS. MS(ΕSI+): m/z = 529.6. Example 31 : 4- (( " 2S,4EZ)-4- (benzyloxy)imino]-2-{ 4-( ' 3,4-dichlorophenyl)-l-piperazinyl]- carbonyl>pyrrolidinyl carbonyl]benzonitrile Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and l-(3,4-dichlorophenyl)piperazine the title compound was obtained in 43% purity by LC/MS. MS(ΕSI+): m z = 576.6. Example 32: (2S,4EZ)-4-(methoxyiminoVN 1 -pentyl-N 2 -r2-( H-pyπol- 1 -vDphenyll- 12- pyπolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 2- (lΗ-pyrrol-1 -yl)phenylamine the title compound was obtained in 74% purity by LC/MS. MS(ΕSI+): m/z = 412.2. pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, acryloyl chloride, and 2-furylmethylamine the title compound was obtained in 74% purity by LC/MS. MS(ΕSI+): m/z = 436.8. Example 34: (2S,4EZ)-4- tert-butoxyimino -N 2 -cyclopropyl-N 1 -( " 3,5-dichloroρhenvπ- 2- pyπolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(tert-butoxyimino)-2-pyπolidinecarboxylic acid, 1 ,3-dichloro-5-iso- cyanatobenzene, and cyclopropylamine the title compound was obtained in 48% purity by LC/MS. MS(ΕSI+): m z = 427.6. Example 35 : r2S.4EZ)-4-rrallyloxy)imino1-N-r2-(diethylamino ethyll- 1 -f (2-oxo-6-pentyl-2H- pyran-3 -yDcarbonyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η- pyran-3 -carbonyl chloride, and Νl,Νl-diefhyl-l,2-ethanediamine the title compound was obtained in 93% purity by LC/MS. MS(ΕSI+): m z = 475.4. Example 36: (2S,4EZ -N 2 -r(2RS)-2-hvdroχy-2-phenethyl1-4-(methoxyimino -N 1 -(3- methylphenyl)- 1 ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1 -isocyanato-3- methylbenzene, and (lRS)-2-amino-l-phenylethanol the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 411.2. Example 37: (2S,4EZ)-l-[(benzoylamino)carbonyl]-N-benzyl-4-[(benzyloxy)imino]-N- methyl-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, benzoyl isocyanate, and Ν- benzyl-Ν-methylamine the title compound was obtained in 40% purity by LC/MS. MS(ΕSI+): m/z = 485.4. Example 38 : (2SAEZ)- 1 -(4-cvanobenzoyl)-N-(9-ethyl-9H-carbazol-3-yl)-4-(methoxyimino - 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(ter/-but- oxycarbonyl)-4-(methoxyimino)-2-pyπolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 72% purity by LC/MS. MS(ΕSI+): m/z = 480.4. Example 39: (2S.4EZ)-4-(methoχyimino -N 1 -(3-methylρhenyl -N 2 -(2-thienylmethyl - 2- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyπolidinecarboxylic acid, 1 -isocyanato-3-methyl- benzene, and 2-thienylmethylamine the title compound was obtained in 98% purity by LC/MS. MS(ΕSI+): m z = 387.2. Example 40: (2S,4EZ)-4-(tert-butoxyiminoVN-r2-methox yethyl)- 1 -[(2-oxo-6-pentyl-2H- PVran-3-yl carbonyl]-2-pyπolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(tert-butoxyimino)-2-pyπolidinecarboxylic acid, 2-oxo-6-ρentyl-2Η- pyran-3 -carbonyl chloride, and 2-methoxyethylamine the title compound was obtained in 75% purity by LC/MS. MS(ΕSI+): m/z = 450.2. Example 41: (3EZ,5S)-5-{[4-( 3-benzodioxol-5-ylmethyl -l-piperazinyl]carbonyl}-l- benzoyl-3-pyrrolidinone O-(3,4-dichlorobenzyl)oxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, benzoyl chloride, and l-(l,3-benzodioxol-5-ylmethyl)piperazine the title compound was obtained in 71% purity by LC/MS. MS(ΕSI+): m/z = 609.8. Example 42: tert-butyl 3-[({(2S.4EZ)-4-rethoxyimino)-l- ( " 2-oxo-6-ρentyl-2H-pyran-3- yl)carbonyl1pyrrolidinvUcarbonyl)amino]-l-azetidinecarboxylate Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-ρyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and tert-butyl 3-amino-l-azetidinecarboxylate the title compound was obtained in 100% purity by LC MS. MS(ΕSI+): m/z = 519.6. Example 43 : (2SAEZ)-4- {[(4-methoxybenzyl)oxy]imino} -N-(3-methylphenyl)-2-(4-morpho- linylcarbonyl -l-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 1- isocyanato-3-methylbenzene, and morpholine the title compound was obtained in 41% purity by LC/MS. MS(ΕSI+): m/z = 467.4. Example 44: (2S,4EZ)-N 2 -cvclopropyl-4-{[(4-methoxybenzyl)oxy]imino>-N 1 -pentyl-l,2- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino} -2-pyπolidinecarboxylic acid, 1 - isocyanatopentane, and cyclopropylamine the title compound was obtained in 75% purity by LC/MS. MS(ΕSI+): m/z = 417.2. Example 45: (3EZ,5S)-5-{[4-(3,4-dichlorophenyl -l-piperazinyl]carbonvU-l-[(2-oxo-6- pentyl-2H-pyran-3-yl)carbonyl]-3-pyπOlidinone O-benzyloxime — Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino] - 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3 - carbonyl chloride, and l-(3,4-dichlorophenyl)piperazine the title compound was obtained in 47% purity by LC/MS. MS(ΕSI+): m/z = 639.8. Example 46: (2S,4EZ)-4-(tert-butoxyimino -N-[2-(lH-pyτrol-l-yl)phenyl]-2-pyrrolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid, and 2-(lΗ-pyrrol-l- yl)phenylamine the title compound was obtained in 83% purity by LC/MS. MS(ΕSI+): m/z = 341.2. Example 47: l-({(2S,4EZ)-4-(chloromethylene -l- (4-chlorophenoxy)acetyl]pyrrolidinyl}- carbonyl -4-(3,4-dichlorophenyl piperazine Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, (4-chlorophenoxy)acetyl chloride, and l-(3,4-dichlorophenyl)piperazine the title compound was obtained in 64% purity by LC/MS. MS(ΕSI+): m z = 543.6. Example 48: (2S,4EZ)-4-r(benzyloxy ' )imino]-N-( ' 4,6-dimethoxy-2-pyrimidinyl -l-[(2-oxo-6- pentyl-2H-pyran-3-yl carbonyl]-2-pyπolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino] - 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3 - carbonyl chloride, and 4,6-dimethoxy-2-pyrimidinamine the title compound was obtained in 62% purity by LC/MS. MS(ΕSI+): m/z = 564.6. Example 49: r2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-l-[4-(dimethylamino)butanoyl1- N-( 1 -naphthylmethyl -2-p yπolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 4- (dimethylamino)butanoyl chloride, and 1-naphthylmethylamine the title compound was obtained in 62% purity by LC/MS. MS(ΕSI+): m/z = 555.6. Example 50: (2S)-N 2 -(2 Λ .3-benzothiadiazol-4-ylVN 1 -(3,5-dichlorophenylV4-oxo-l .2-ρyrroli- dinedicarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxy- cafbonyl)-4-oxoproline, l,3-dichloro-5-isocyanatobenzene, and 2,l,3-benzothiadiazol-4-amine the title compound was obtained in 47% purity by LC/MS. MS(ESI+): m z = 450.6. Example 51 : (2S,4EZ)-N-benzyl-4-(chloromethylene -N-methyl-l-(4-phenoxybenzoyl)-2- pyπolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and Ν-benzyl-Ν-methylamine the title compound was obtained in 61% purity by LC/MS. MS(ΕSI+): m/z = 461.4. Example 52: (2S,4EZ)-N 2 -(9-ethyl-9H-carbazol-3-ylV4-{r(4-methoχybenzvnoxy1imino>-N 1 - (3 -mefhylphenylV 1 ,2-p yrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 1-isocya-nato- 3-methylbenzene, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 72% purity by LC/MS. MS(ΕSI+): m/z = 590.8. Example 53 : (2S)-N-(ter/-butyl -4-methylene-l -[(2-oxo-6-pentyl-2H-pyran-3-yl carbonvn-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxy- carbonyl)-4-methyleneproline, 2-oxo-6-pentyl-2Η-pyran-3 -carbonyl chloride, and tert- butylamine the title compound was obtained in 100% purity by LC/MS. MS(ESI+): m/z = 375.4. Example 54: (2S,4EZ)-4-benzylidene-l-f4-(dimethylamino butanoyn-N-(6-quinolinyl)-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene- 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-(dimethylamino)butanoyl chloride, and 6-quinolinamine the title compound was obtained in 71% purity by LC/MS. MS(ΕSI+): m/z = 443.6. Example 55 : (2S)-l-[4-(dimethylamino butanoyl]-N-(9-ethyl-9H-carbazol-3-yl -4-methylene- 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, 4-(dimethylamino)butanoyl chloride, and 9-ethyl-9Η-carbazol-3- amine the title compound was obtained in 51% purity by LC/MS. MS(ESI+): m/z = 433.6. Example 56: (2S,4EZ)-N-( 3-benzodioxol-5-ylmethyl -4-[(benzyloxy imino]-l-(4-cyano- benzoyl)-2-pyπolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and l,3-benzodioxol-5-ylmethylamine the title compound was obtained in 51% purity by LC/MS. MS(ESI+): m/z = 497.6. Example 57 : (2S)- 1 -( { 1 -[4-(dimethylamino butanoyl] -4-methylene-2-ρyrrolidiny carbonvD- 3-azetidinol Following the general method as outlined in Example 22, starting from l-(tert-butoxy- carbonyl)-4-methyleneproline, 4-(dimethylamino)butanoyl chloride, and 3-azetidinol the title compound was obtained in 100% purity by LC/MS. MS(ESI+): m/z = 296.4. Example 58 : (2SAEZ)- 1 -(F 1 , 1 '-biphenyll-4-ylcarbonylV4- { [(3,4-dichlorobenzyl oχy]imino) - N-[2-(lH-pyπol- 1 -yl phenyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, [1,1 '- biphenyl] -4-carbonyl chloride, and 2-(lΗ-pyrrol-l-yl)phenylamine the title compound was obtained in 54% purity by LC/MS. MS(ΕSH-): m/z = 623.6. Example 59: (2S,4EZ)-4-benzylidene-l-[(4-chlorophenoxy)acetyl]-N-(3,4-dimethoxybenzyl)- 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, (4-chlorophenoxy)acetyl chlo-ride, and 3,4-dimethoxybenzylamine the title compound was obtained in 49% purity by LC/MS. MS(ΕSI+): m/z = 521.6. Example 60: (2SAEZ)-4- { [(3 ,4-dichlorobenzyl)oχylimino> -1 -(diphenylacetylVN-(2-thienyl- methyl)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- { [(3 ,4-dichlorobenzyl)oxy]imino } -2-pynolidinecarboxylic acid, diphen- ylacetyl chloride, and 2-thienylmethylamine the title compound was obtained in 51% purity by LC/MS. MS(ΕSI+): m/z = 592.6. Example 61 : (2S,4EZ -N-(3,4-dimethoxybenzyl -l-(diphenylacetyl -4-(methoxyimino)-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 74% purity by LC/MS. MS(ΕSI+): m/z = 502.6. Example 62: (2S,4EZ)-N 1 -(3.5-dichlorophenyn-4-(ethoxyiminoVN 2 -[2-(lH-ρyrrol-l - yPphenyl] - 1 ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ) l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, l,3-dichloro-5-isocyanato- benzene, and 2-(lH-pyrrol-l-yl)phenylamine the title compound was obtained in 54% purity by LC/MS. MS(ΕSI+): m/z = 500.6. Example 63 : (2SAEZ)-N 2 -( 1 ■3-benzodioxol-5-ylmethyl -4- { [(4-methoxybenzyl oxy]imino) - N^pentyl-l^-p olidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, 1 -isocyanatopentane, and l,3-benzodioxol-5-ylmethylamine the title compound was obtained in 63% purity by LC/MS. MS(ΕSI+): m/z = 511.4. Example 64: (2S,4EZ)-N-benzyl-4-[(benzyloxy)iminol-l-(diphenylacetyl -N-methyl-2-pyrro- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and Ν-benzyl-Ν-methylamine the title compound was obtained in 42% purity by LC/MS. MS(ΕSI+): m/z = 532.4. Example 65: (2S,4EZ)-N-(2J,3-benzothiadiazol-4-vn-l-(π J'-biphenyll-4-ylcarbonylV4- (methoxyimino -2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyπolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and 2, 1 ,3-benzothiadiazol-4-amine the title compound was obtained in 66% purity by LC/MS. MS(ΕSI+): m z = 472.4. Example 66: (2S,4EZ -l-([l,r-biphenyl]-4-ylcarbonyl -4-(methoxyimino -N-(6-quinolinylV2- pyπolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrcolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and 6-quinolinamine the title compound was obtained in 79% purity by LC/MS. MS(ΕSI+): m/z = 465.4. Example 67: (2S,4EZ)-l-acetoacetyl-N-benizyl-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2,4-oxetanedione, and benzylamine the title compound was obtained in 45% purity by LC MS. MS(ΕSI+): m/z = 332.2. Example 68 : (2SAEZ)- 1 -(T .1 '-biphenyl] -4-ylcarbonylV4-(chloromethyleneVN-(2-furyl- methyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, [1,1' -biphenyl] -4-carbo-nyl chloride, and 2-furylmethylamine the title compound was obtained in 70% purity by LC/MS. MS(ΕSI+): m/z = 421.4. Example 69 : (2SAEZ)- 1 -[(4-chlorophenoxy)acetyl]-4- { [(3 ,4-dichlorobenzyl)oxy1imino> -N- [(2RS)-2-hydroxy-2-phenethyl]-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, (4-chloro- phenoxy)acetyl chloride, and (lRS)-2-amino-l-phenylethanol the title compound was obtained in 62% purity by LC/MS. MS(ΕSI+): m z = 590.8. Example 70: (2S,4EZ)-N-allyl- 1 -([ 1 , 1 '-biphenvn-4-ylcarbonyl)-4-(methoxyimino)-2-pyrro- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and allylarnine the title compound was obtained in 87% purity by LC/MS. MS(ΕSI+): m/z = 378.2. Example 71: (2S.4EZ)-l-([lJ'-biphenyl]-4-ylcarbonyl)-4-(methoχyiminoVN-(2-thienyl- methyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [l,l'-biphenyl]-4-carbonyl chloride, and 2-thienylmethylamine the title compound was obtained in 78% purity by LC/MS. MS(ΕSI+): m/z = 434.4. Example 72: (2S.4EZ)-4-(cvanomethylene -N-(2-furylmethyl -l-r(2-oxo-6-pentyl-2H-pyran- 3 -vDcarbonyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomefhylene)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and 2-furylmefhylamine the title compound was obtained in 34% purity by LC/MS. MS(ΕSI+): m/z = 424.4. Example 73 : (2SAEZ)- 1 -([ 1 , 1 '-biphenyn-4-ylcarbonyl -N-(2-furylmethyl)-4-(methoxyimino)- 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,l'-biphenyl]-4-carbonyl chloride, and 2-furylmethylamine the title compound was obtained in 75% purity by LC/MS. MS(ΕSI+): m/z = 418.4. Example 74: (2SAEZ)- 1 -acetyl-N-cyclopropyl-4- { [(3 ,4-dichlorobenzyl)oxy]imino> -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(3,4-dichlorobenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, acetyl chloride, and cyclopropylamine the title compound was obtained in 52% purity by LC/MS. MS(ΕSI+): m/z = 384.4. Example 75 (2S,4E2^-N-(2-furylmethyl -4-(methoxyimino)-l-[( ' 2-oxo-6-pentyl-2H-ρyran-3- yl carbonyll-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2H-pyran-3- carbonyl chloride, and 2-furylmethylamine the title compound was obtained in 62% purity by LC/MS. MS(ΕSI+): m/z = 430.4. Example 76: (2S,4EZ)-N-benzyl-l-( l, -biphenyl1-4-ylcarbonyl -4-(methoxyimino -N- methyl-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [ 1 , 1 ' -biphenyl] -4-carbonyl chloride, and Ν-benzyl-Ν-methylamine the title compound was obtained in 67% purity by LC/MS. MS(ΕSI+): m z = 442.4. Example 77: (2S,4E )-l-(diphenylacetyl -4-(ethoxyimino)-N-(2-thienylmethyl)-2-pyrrolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-buto- xycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2- thienylmethylamine the title compound was obtained in 74% purity by LC/MS. MS(ΕSI+): m/z = 462.4. Example 78: (2S,4EZ -N-(2,l,3-benzothiadiazol-4-yl -4-(cyanomethylene)-l-(diphenylacetyl)- 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomethylene)-2-ρyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2,l,3-benzothiadiazol-4-amine the title compound was obtained in 42% purity by LC/MS. MS(ΕSI+): m/z = 480.4. Example 79: (2S)-1 -(diphenylacetyl)-N-(l -naphthylmethyl -4-oxo-2-pyπolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-oxoproline, diphenylacetyl chloride, and 1-naphthylmethylamine the title com-pound was obtained in 60% purity by LC/MS. MS(ESI+): m/z = 463.4. Example 80: (3EZ,5S -5-(lH-benzimidazol-2-yl)-l-(diphenylacetyl -3-pyrrolidinone O- methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-ρyrrolidinecarboxylic acid, diphenylacetyl chloride, and 1,2-benzenediamine the title compound was obtained in 72% purity by LC/MS. MS(ΕSI+): m/z = 425.4. Example 81 : (2S)-2-ri-([l '-biphenyll-4-ylcarbonyD-4-methylene-2-pyrrolidinyl1-lH-benz- imidazole Following the general method as outlined in Example 22, starting from l-(tert-butoxy- carbonyl)-4-methyleneproline, [1,1 '-biphenyl] -4-carbonyl chloride, and 1,2-benzenedi-amine the title compound was obtained in 73% purity by LC/MS. MS(ESI+): m z = 380.4. Example 82: (2S,4EZ)-l-([lJ , -biphenyl]-4-ylcarbonylV4-(chloromethylene -N-(2-methoxy- ethyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4- carbonyl chloride, and 2-methoxyethylamine the title compound was obtained in 55% purity by LC/MS. MS(ΕSI+): m/z = 399.6. Example 83: (SEZ.SS^-S-flH-benzimidazol-Σ-yD-l-CdiphenylacetvD-S-pyrrolidinone O- allyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 1,2-benzenediamine the title compound was obtained in 63% purity by LC MS. MS(ΕSI+): m/z = 451.4. Example 84: (2S.4EZ)-l-(r r-biphenyll-4-ylcarbonylVN-r2-(diethylamino)ethyll-4- (methoxyimino -2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,1 '-biphenyl] -4-carbonyl chloride, and Νl,Νl-diethyl-l,2-ethanediamine the title compound was obtained in 90% purity by LC/MS. MS(ΕSI+): m/z = 437.4. Example 85: (2S,4EZ)-l-(diphenylacetyl -4-{[(4-methoxybenzyl oxy]iminol-N-(2-thienyl- methyl -2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxyca bonyι)-4- {[(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2-thienylmethylamine the title compound was obtained in 63% purity by LC MS. MS(ΕSI+): m z = 554.4. Example 86: (2S,4EZ)-l-( l'-biphenyll-4-ylcarbonyl -N-(3,4-dimethoxybenzyl)-4-(methoxy- imino^-Σ-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l~(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 58% purity by LC/MS. MS(ΕSI+): m/z = 488.4. Example 87 : (2SAED- 1 -aceto acetyl-4-(methoxyiminoVN-( 1 -naphthylmethylV 2-pyrcolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2,4-oxetanedione, and 1- naphthylmethylamine the title compound was obtained in 40% purity by LC/MS. MS(ΕSI+): m/z = 382.2. Example 88: (2S,4E )-N-allyl-4-l (3,4-dichlorobenzyl)oxy]imino>-l-( ' diphenylacetyl -2- pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and allylamine the title compound was obtained in 54% purity by LC/MS. MS(ΕSI+): m/z = 536.6. Example 89 : (2SAED-4- { r(3 ,4-dichlorobenzyl oxy1imino} -N 1 -pentyl-N 2 -(6-quinolinyn- 12- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 6-quinolinamine the title compound was obtained in 54% purity by LC/MS. MS(ΕSI+): m z = 542.6. Example 90: (2S,4EZ)-4-(chloromethyleneVl -(diphenylacetyl -N-r(2RS -2-hvdroxy-2- phenethyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and (lRS)-2-amino-l-phenylethanol the title compound was obtained in 87% purity by LC/MS. MS(ΕSI+): m/z = 475.4. Example 91 : (2S)-1 -([ 1.1 '-biphenyl]-4-ylcarbonvn-N-[(2RS)-2-hvdroxy-2-ρhenethvn-4- methylene-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, [l,l'-biphenyl]-4-carbonyl chloride, and 2-amino-l-phenyl- ethanol the title compound was obtained in 74% purity by LC/MS. MS(ESI+): m/z = 427.4. Example 92: (2S,4EZ)-l-([ia'-biphenyl]-4-ylcarbonyl -4-(chloromethylene -N-(6-quinolinyl - 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pynolidinecarboxylic acid, [l,l'-biphenyl]-4-carbo-nyl chloride, and 6-quinolinamine the title compound was obtained in 73% purity by LC/MS. MS(ΕSI+): m/z = 468.4. Example 93 : (2S,4EZ)-4-benzylidene-N-[2-(diethylamino ethyl]-l -(diphenylacetyl -2-pyrro- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and Ν1,Ν1 -diethyl- 1,2-efhanediamine the title compound was obtained in 71% purity by LC/MS. MS(ΕSI+): m/z = 496.4. Example 94: (2S,4EZ -l-acetoacetyl-4-(methoxyimino -N-(2-thienylmethyl -2-pynolidinecar- boxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2,4-oxetanedione, and 2- thienylmethylamine the title compound was obtained in 42% purity by LC/MS. MS(ΕSI+): m/z = 338.2. Example 95 : (2SAEZ)-1 -acetyl-4- { [(3 ,4-dichlorobenzyl oxy]imino> -N-(2-hydroxy-2-phenyl- ethyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- { [(3 ,4-dichlorobenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, acetyl chloride, and (lRS)-2-amino-l-phenylethanol the title compound was obtained in 48% purity by LC/MS. MS(ΕSI+): m/z = 464.6. Example 96: (2S,4EZ)-4-{ (3,4-dichlorobenzyl oxy1iminol-N 1 -(3.5-dichlorophenylVN 2 -(6- quinolinyl)- 1 ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 1,3- dichloro-5-isocyanatobenzene, and 6-quinolinamine the title compound was obtained in 66% purity by LC/MS. MS(ΕSI+): m/z = 617.2. Example 97: (2S,4EZ -4-(methoxyimino)-N-(l-naρhthylmethyl ' )-l-(phenoχyacetyl v )-2-pyrro- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 1- naphthylmethylamine the title compound was obtained in 99% purity by LC/MS. MS(ΕSI+): m/z = 432.2. Example 98: (2S.4EZ)-4-(chloromethylene -N-(3,4-dimethoxybenzylVl-[(2-oxo-6-pentyl-2H- pyran-3 - vDcarbonyl] -2-p yrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2H-ρyran-3- carbonyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 51% purity by LC/MS. MS(ΕSI+): m/z = 503.4. Example 99: (2SAEZ)-1 -(diphenylacetyl -4-(methoxyimino -N-(2-thienylmethyl)-2-pyrroli- dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2- thienylmethylamine the title compound was obtained in 88% purity by LC/MS. MS(ΕSI+): m/z = 448.4. Example 100 : (2S,4EZ)-N-benzyl- 1 -(diphenylacetyl)-4-(methoxyimino -2-pyrrolidinecar- boxamide Following the general method as outlined in Example 22, starting from oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, diphenylacetyl chloride, and benzylamine the title compound was obtained in 82% purity by LC/MS. MS(ΕSI+): m/z = 442.4. Example 101: (2S,4EZ)-l-([lJ'-biphenyl1-4-ylcarbonyl)-4-([(3.4-dichlorobenzyl oxy]imino>- N- [2-(diethylamino)ethyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pynolidinecarboxylic acid, [1,1 '-bi- phenyl]-4-carbonyl chloride, and Ν1,Ν1 -diethyl- 1,2-ethanediamine the title compound was obtained in 74% purity by LC MS. MS(ΕSI+): m/z = 581.6. Example 102: (2S,4EZ)-4-f[(3,4-dichlorobenzyl)oxy]imino}-l-[4-( , dimethylamino butanoyl]- N-(6-quinolinyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- { [(3 ,4-dichlorobenzyl)oxy]imino } -2-pyrrolidinecarboxylic acid, 4-(dime- thylamino)butanoyl chloride, and 6-quinolinamine the title compound was obtained in 95% purity by LC/MS. MS(ΕSI+): m/z = 542.6. Example 103: (2S.4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-( ' 5-ethyl- 3,4-thiadiazol-2-yl -4- fmethoχyimino -2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,1 '-biphenyl] -4-carbonyl chloride, and 5-ethyl-l,3,4-fhiadiazol-2-amine the title compound was obtained in 89% purity by LC MS. MS(ΕSI+): m/z = 450.2. Example 104: (2S.4EZ)-N-benzyl- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2-pyno- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and benzylamine the title compound was obtained in 72% purity by LC/MS. MS(ΕSI+): m/z = 428.2. Example 105 : (2S,4EZ)-N-benzyl- 1 -(diphenylacetyl -4-(ethoxyimino -2-pynolidinecarbox- amide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pynolidinecarboxylic acid, diphenylacetyl chloride, and benzylamine the title compound was obtained in 53% purity by LC/MS. MS(ESI+): m/z = 456.4. Example 106: (2S,4EZ)-N 2 -cvclopropyl-4-{[(3,4-dichlorobenzyl oxy]imino}-N 1 -(3-methoxy- phenyl)-l,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(3,4-dichlorobenzyl)oxy]imino} -2-pynolidinecarboxylic acid, 1 -isocya- nato-3-methoxybenzene, and cyclopropylamine the title compound was obtained in 45% purity by LC/MS. MS(ΕSI+): m/z = 491.6. Example 107: (2S,4EZ)-l-( ' diphenylacetyl -N-r(2RS)-2-hydroxy-2-phenethyll-4-{rf4- methoxyben-zyl)oxy]imino}-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and (lRS)-2-amino-l-phenylethanol the title compound was obtained in 66% purity by LC/MS. MS(ΕSI+): m/z = 578.4. Example 108: (2S)-N-(2-furylmethyl -4-methylene-l-f( , 2-oxo-6-ρentyl-2H-ρyran-3- yl carbonyll-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneρroline, 2-oxo-6-pentyl-2Η-pyran-3-carbonyl chloride, and 2-furyl- methylamine the title compound was obtained in 43% purity by LC/MS. MS(ESI+): m/z = 399.2. Example 109: (2S,4EZ)-N-(2J.3-benzothiadiazol-4-ylVl-(diphenylacetyl -4-rmethoxyimino)- 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(mefhoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2,l,3-benzothiadiazol-4-amine the title compound was obtained in 69% purity by LC/MS. MS(ΕSI+): m/z = 486.4. Example 110: (2S)-Nl-(3.5-dichlorophenyl -N2-(3.4-dimethoxybenzyl -4-oxo-1.2- pyrrolidine-dicarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxy- carbonyl)-4-oxoproline, l,3-dichloro-5-isocyanatobenzene, and 3,4-dimethoxybenzylamine the title compound was obtained in 48% purity by LC/MS. MS(ESI+): m/z = 466.6. Example 111: (2S,4EZ)-N-benzyl-l-(diphenylacetyl)-4-{[(4-methoxybenzyl oxy]imino}-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and benzylamine the title compound was obtained in 60% purity by LC/MS. MS(ΕSI+): m/z = 548.4. Example 112: (2S.4EZ)-l-benzoyl-4-{r(3,4-dichlorobenzvnoxylimino)-N-(6-quinolinylV2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{ [(3 ,4-dichlorobenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, benzoyl chloride, and 6-quinolinamine the title compound was obtained in 67% purity by LC/MS. MS(ΕSI+): m/z = 533.6. Example 113: (2S,4EZ)-l-acetoacetyl-N-cycloρropyl-4-{[(3,4-dichlorobenzyl oxy]imino}-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 2,4- oxetanedione, and cyclopropylamine the title compound was obtained in 76% purity by LC/MS. MS(ΕSI+): m/z = 426.6. Example 114: (2SAEZ)-4-{ [(3,4-dichlorobenzvDoxyliminoμN 2 -[(2RS)-2-hvdroxy-2- phenethy^-N^pentyl-l^-pynolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{ [(3 ,4-dichlorobenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, 1-isocya- natopentane, and (lRS)-2-amino-l-phenylethanol the title compound was obtained in 47% purity by LC/MS. MS(ESI+): m/z = 535.6. Example 115: (2S,4EZ)-4- (benzyloxy imino]-N-(l-naphthylmethyl)-l-(phenoxyacetyl -2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 1-naphthylmethylamine the title compound was obtained in 74% purity by LC/MS. MS(ΕSI+): m/z = 508.4. Example 116: (2S)- !-([!,! '-biphenyl] -4-ylcarbonyl -4-methylene-N-(6-quinolinyl -2-pyrroli- dinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxy- carbonyl)-4-methyleneproline, [l,l'-biphenyl]-4-carbonyl chloride, and 6-quinolinamine the title compound was obtained in 88% purity by LC/MS. MS(ESI+): m/z = 434.2. Example 117: (2S,4EZ)-N-cycloprop yl-4- { [(3 ,4-dichlorobenzyl)oxy]imino } - 1 -(diphenyl- acetyl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and cyclopropylamine the title compound was obtained in 49% purity by LC/MS. MS(ΕSI+): m/z = 536.6. Example 118: (2S.4EZ)-l-(4-cvanobenzoyl)-4-{r( ' 3.4-dichlorobenzyl oxylimino -N-(6- quinolinyl -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4- {[(3,4-dichlorobenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, 4- cyanobenzoyl chloride, and 6-quinolinamine the title compound was obtained in 52% purity by LC/MS. MS(ΕSI+): m/z = 558.6. Example 119: (2S -4-oxo-l-(phenoxyacetylVN-r2-(lH-pyrrol-l-yl)ρhenyl]-2- pyrrolidinecarbox-amide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-oxoproline, phenoxyacetyl chloride, and 2-(lΗ-pyrrol-l-yl)phenylamine the title compound was obtained in 42% purity by LC/MS. MS(ESI+): m/z = 404.2. Example 120: (2S,4EZ -N-cvcloprop yl-4- ( [(3 ,4-dichlorobenzvDox v]imino 1-1 -(methox v- acetyD-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, methoxyacetyl chloride, and cyclopropylamine the title compound was obtained in 54% purity by LC/MS. MS(ΕSI+): m/z = 414.6. Example 121: (2SAEZ)-N-( 1 ,3-benzodioxol-5-ylmethylV 1-(T1,1 '-biphenyll-4-ylcarbonylV4- (methoxyimino^-Σ-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1' -biphenyl] -4-carbonyl chloride, and l,3-benzodioxol-5-ylmethylamine the title compound was obtained in 64% purity by LC/MS. MS(ΕSI+): m/z = 472.4. Example 122: (3EZ,5S)-5-[(4-acetyl-l-piperazinyl carbonyl]-l-acryloyl-3-pyrrolidinone O- (3,4-dichlorobenzyl oxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(3 ,4-dichlorobenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, acryloyl chloride, and 1-acetylpiperazine the title compound was obtained in 79% purity by LC/MS. MS(ΕSI+): m/z = 467.6. Example 123: (2S -l-([lJ'-biphenyll-4-ylcarbonyl -N-(2-furylmethyl -4-methylene-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, [1,1 '-biphenyl] -4-carbonyl chloride, and 2-furylmethylamine the title compound was obtained in 94% purity by LC/MS. MS(ESI+): m/z = 387.2. Example 124: (2S,4EZ)-4-(cyanomethylene -N-(3 ,4-dimethoxybenzyl - 1 -[(2-oxo-6-pentyl- 2H-pyran-3-yl carbonyl1-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 65% purity by LC/MS. MS(ΕSI+): m/z = 494.4. Example 125: (2S,4EZ)-l-[(benzoylamino carbonyl]-4-(cyanomethylene -N-(9-ethyl-9H- carbazol-3-yl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, benzoyl isocyanate, and 9- ethyl-9Η-carbazol-3-amine the title compound was obtained in 74% purity by LC/MS. MS(ΕSI+): m/z = 492.4. Example 126; (2S,4EZ)-l-benzoyl-N-[2-(diethylamino)ethyl]-4-( ' methoxyimino)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, benzoyl chloride, and Νl,Νl-diethyl-l,2-ethanediamine the title compound was obtained in 80% purity by LC/MS. MS(ΕSI+): m/z = 361.2. Example 127: (2S,4EZ)-N-r2-( , diethylamino ethyll-l-(diphenylacetyl)-4-(ethoxyimino)-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(efhoxyimino)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and Nl,Nl-diethyl-l,2-ethanediamine the title compound was obtained in 50% purity by LC/MS. MS(ESI+): m/z = 465.4. Example 128: (2S,4EZ)-N-(2J.3-benzothiadiazol-4-yl -4-[(benzyloxy imino]-l-(4-cvano- benzoyl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pynolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 2,l,3-benzothiadiazol-4-amine the title compound was obtained in 55% purity by LC/MS. MS(ΕSI+): m z = 497.4. Example 129: (2EZ)-r5-dH-benzimidazol-2-ylVl-([l.l'-biphenyll-4-ylcarbonvn-3-pyrro- lidinylidene]ethanenitrile Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, [1 ,1 '-biphenyl]-4-carbonyl chloride, and 1,2-benzenediamine the title compound was obtained in 70% purity by LC/MS. MS(ΕSI+): m/z = 405.2. Example 130: (2S,4EZ)-4-(chloromethylene)-N-(9-ethyl-9H-carbazol-3-yl)-l- (phenoxyacetyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pynolidinecarboxylic acid, phenoxyacetyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 63% purity by LC/MS. MS(ΕSI+): m/z = 488.6. Example 131 : (2S)-N 2 -(9-ethyl-9H-carbazol-3-ylVN 1 -(3-methoχyphenvn-4-methylene- 2- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, l-isocyanato-3-methoxybenzene, and 9-ethyl-9H-carbazol-3- amine the title compound was obtained in 47% purity by LC/MS. MS(ESI+): m/z = 469.4. Exa ple 132: r2S.4EZ)-4-( " cvanomethyleneVN-r9-ethyl-9H-carbazol-3-yl -2-pyrrolidinecar- boxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, and 9-ethyl-9H-carbazol- 3-amine the title compound was obtained in 36% purity by LC/MS. MS(ΕSI+): m/z = 345.2. Example 133: (2SAEZ)- 1 -(4-c vanobenzoyl)-N- 2-(diethylamino)ethyl]-4-(methoxyimino)-2- pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and Νl,Νl-diethyl-l,2-ethanediamine the title compound was obtained in 58% purity by LC/MS. MS(ΕSI+): m/z = 386.2. Example 134: 4-|[(2S,4EZ)-2-(lH-benzimidazol-2-yl -4-(cvanomethylene^pynolidinyl]- carbonyUbenzonitrile Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 1,2-benzenediamine the title compound was obtained in 84% purity by LC/MS. MS(ΕSI+): m/z = 354.2. Example 135: (2S,4EZ)-4-[(allyloxynmino]-l-[4-(dimethylamino butanoyll-N-(9-ethyl-9H- carbazol-3-yl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyl- oxy)imino]- 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-(dimethylamino)-butanoyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 40% purity by LC/MS. MS(ΕSI+): m/z = 490.4. Example 136: (2S,4EZ)-4-benzylidene-N-(9-ethyl-9H-carbazol-3-yl)-2-pynolidinecarbox- amide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 53% purity by LC/MS. MS(ΕSI+): m/z = 396.2. Example 137: (2S,4EZ)-4-benzylidene-l-[4-( ' dimethylamino butanoyll-N-(9-ethyl-9H-carba- zol-3-yl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene-1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-(dimethylamino)butanoyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 74% purity by LC MS. MS(ΕSI+): m/z = 509.4. Example 138: (2S,4EZ)-4-(chloromethylene -N-(9-ethyl-9H-carbazol-3-vn-2-pyrrolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, and 9-ethyl-9Η-carbazol- 3-amine the title compound was obtained in 73% purity by LC/MS. MS(ΕSI+): m/z - 354.4. Example 139: (2S)-N-(9-ethyl-9H-carbazol-3-yl ' )-4-methylene-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 71% purity by LC/MS. MS(ESI+): m/z = 320.2. Example 140: (2S.4EZ)-4-(cyanomethylene -N-(9-ethyl-9H-carbazol-3-yl -l-(4-phenoxy- benzoyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chlo-ride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 37% purity by LC/MS. MS(ΕSI+): m/z = 541.4. Example 141 : N-{[(2S.4EZ)-2-(lH-benzimidazol-2-yl)-4-(chloromefhylene)pyrrolidinvn- carbonyllbenzamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, benzoyl isocyanate, and 1,2-benzenediamine the title compound was obtained in 51% purity by LC/MS. MS(ΕSI+): m z = 381.4. Example 142: (2SVN 1 -(3,5-dichloroρhenyl -N 2 -(9-ethyl-9H-carbazol-3-vn-4-methylene- 2- pyrrolidinedi carboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, l,3-dichloro-5-isocyanatobenzene, and 9-ethyl-9Η-carbazol-3- amine the title compound was obtained in 40% purity by LC/MS. MS(ESI+): m/z = 507.6. Example 143: (2S)- 1 -(diphenylacetyl)-N-(9-ethyl-9H-carbazol-3 -yl)-4-methylene-2-pyrro- lidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, diphenylacetyl chloride, and 9-ethyl-9Η-carbazol-3 -amine the title compound was obtained in 42% purity by LC/MS. MS(ESI+): m/z = 514.4. Example 144: (2S,4EZ)-l-benzoyl-4-(chloromethylene)-N-(9-ethyl-9H-carbazol-3-vn-2- pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and 9- ethyl-9Η-carbazol-3-amine the title compound was obtained in 48% purity by LC/MS. MS(ΕSI+): m/z = 458.4. Example 145: (2S.4EZ)-l-([l.r-biphenyll-4-ylcarbonyl -4-( , cvanomethylene -N-(9-ethyl-9H- carbazol-3-yl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomethylene)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 32% purity by LC/MS. MS(ΕSI+): m/z = 525.4. Example 146: (2S,4EZ)-4-rcvanomethylene -N-(9-ethyl-9H-carbazol-3-yl)-l-(3-oxobutyl)-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomethylene)-2-pynolidinecarboxylic acid, 3-buten-2-one, and 9-ethyl- 9Η-carbazol-3-amine the title compound was obtained in 59% purity by LC/MS. MS(ΕSI+): m z = 415.2. Example 147 : (2S)- 1 -[(4-chlorophenoxy acetyl] -N-(9-ethyl-9H-carbazol-3-yl -4-methylene-2- pyπOlidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, (4-chloroρhenoxy)acetyl chloride, and 9-ethyl-9Η-carbazol-3- amine the title compound was obtained in 100% purity by LC/MS. MS(ESI+): m/z = 488.4. Example 148: (2S)-l-([ l , -biphenyll-4-ylcarbonvn-N-(9-ethyl-9H-carbazol-3-yl)-4- methylene-2-ρyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, [l,l'-biphenyl]-4-carbonyl chloride, and 9-ethyl-9H-carbazol-3- amine the title compound was obtained in 46% purity by LC/MS. MS(ESI+): m/z = 500.4. Example 149: 2-[(2S.4EZ)-4-(chloromethylene)pynolidinyl]-lH-benzimidazole Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, and 1,2-benzenediamine the title compound was obtained in 43% purity by LC/MS. MS(ΕSI+): m/z = 234.4. Example 150: (2S EZ -4-(ethoxyimino -N-( " 9-ethyl-9H-carbazol-3-yl -2-pynolidinecarbox- amide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 91% purity by LC/MS. MS(ΕSI+): m/z = 365.2. Example 151: (2S)- 1 -benzoyl-N-(9-ethyl-9H-carbazol-3-yl -4-methylene-2-pyrrolidinecarbox- amide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, benzoyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 52% purity by LC/MS. MS(ESI+): m/z = 424.2. Example 152: (2S.4EZ)-N-r2-(diethylamino ethyll-l-(diphenylacetyl -4-(r(4-methoxybeή- zyl oxy]imino}-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and Νl ,Ν1 -diethyl- 1 ,2-ethanediamine the title compound was obtained in 56% purity by LC/MS. MS(ΕSI+): m/z = 557.4. Example 144153 (2S.4EZ -l-benzoyl-N-r2-furylmethylV4-(r(4-methoxybenzv oxy1imino>-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, benzoyl chloride, and 2-furylmethylamine the title compound was obtained in 40% purity by LC/MS. MS(ΕSI+): m/z = 448.2. Example 154: (2S.4EZ)-4-(tert-butoxyimino -N-r2-(diethylamino ethyl]-l-(diphenylacetyl -2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(tert-butoxyimino)-2-pynolidinecarboxylic acid, diphenylacetyl chloride, and N1,N1 -diethyl- 1,2-ethanediamine the title compound was obtained in 80% purity by LC/MS. MS(ΕSI+): m/z = 493.4. Example 155: (2S)- 1 -(T 1 , 1 '-biphenyl1-4-ylcarbonyl)-N-( " 3.4-dimethoxybenzyl -4-methylene-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-mefhyleneproline, [1,1 '-biphenyl] -4-carbonyl chloride, and 3,4-dimethoxybenzyl- amine the title compound was obtained in 72% purity by LC/MS. MS(ESI+): m/z = 457.2. Example 156: (2S.4EZ)-4-(cvanomethylene -N 1 -(3.5-dichlorophenyl -N 2 -(9-ethyl-9H-carba- zol-3-yl)-1.2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(cyanomethylene)-2-pynolidinecarboxylic acid, 1 ,3-dichloro-5-isocyana- tobenzene, and 9-ethyl-9Η-carbazol-3 -amine the title compound was obtained in 60% purity by LC/MS. MS(ΕSI+): m z = 532.8. Example 157: r2S.4EZ)-4-r(allyloxy iminol-N 2 -r9-ethyl-9H-carbazol-3-ylVN 1 -phenyl- 12- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, isocyanatobenzene, and 9-ethyl-9Η-carbazol-3 -amine the title compound was obtained in 67% purity by LC/MS. MS(ΕSI+): m/z = 496.4. Example 158: qS^-^-fg-ethyl-gH-carbazol-S-vn^-methylene-N^phenyl-l^- pyrrolidinedicar-boxamide - no- Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, isocyanatobenzene, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 66% purity by LC/MS. MS(ESI+): m z = 439.2. Example 159: (2S,4EZ)-N 2 -(2J.3-benzothiadiazol-4-yl)-N 1 -(3,5-dichloroρhenyl)-4-(methoxy- imino)- 1 ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1 ,3-dichloro-5-isocyanato- benzene, and 2,l,3-benzothiadiazol-4-amine the title compound was obtained in 55% purity by LC/MS. MS(ΕSI+): m/z = 479.6. Example 160: (2EZ -r5-(lH-benzimidazol-2-yl -l-(4-phenoxybenzoyl -3-pyrrolidinyli- dene] ethanenitrile Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and 1,2-benzenediamine the title compound was obtained in 90% purity by LC/MS. MS(ΕSI+): m/z = 421.2. Example 161 : (2S,4EZ)-4-('tert-butoχyimino)-l-( , 2-ethoxy-l-naphthoyn-N-(9-ethyl-9H-carba- zol-3-yl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid, 2-ethoxy- 1 -naphthoyl chloride, and 9-efhyl-9Η-carbazol-3-amine the title compound was obtained in 47% purity by LC/MS. MS(ΕSI+): m/z = 591.4. Example 162: (2S,4EZ)-l-benzoyl-N-[2-(diefhylamino ' )ethyl]-4-(ethoxyimino ' )-2-pyrroli- dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and Ν1,Ν1- - I l l — diethyl- 1,2-ethanediamine the title compound was obtained in 84% purity by LC/MS. MS(ESI+): m/z = 375.2. Example 163 : (2SAEZ)-N 2 -(2 Λ .3-ben2othiadiazol-4-ylV4-r(benzyloxy mino]-N 1 -phenyl-12- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, isocyanatobenzene, and 2,l,3-benzothiadiazol-4-amine the title compound was obtained in 57% purity by LC/MS. MS(ΕSI+): m/z = 487.4. Example 164: (2S,4EZ)-l-(4-cyanobenzoyl)-4-{r(3,4-dichlorobenzyl ' )oxy]imino}-N-(l-naph- thylmethyl)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- { [(3,4-dichlorobenzyl)oxy]imino} -2-pynolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 1-naphthylmethylamine the title compound was obtained in 39% purity by LC/MS. MS(ΕSI+): m/z = 571.6. Example 165 : (2SAEZ)-N-(2.1 ,3-benzothiadiazol-4-yl - l-benzoyl-4- ir(4-methoxybenzylV oxy1imino>-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- { [(4-methoxybenzyl)oxy]imino} -2-pynolidinecarboxylic acid, benzoyl chloride, and 2,l,3-benzothiadiazol-4-amine the title compound was obtained in 61% purity by LC/MS. MS(ΕSI+): m/z = 502.4. Example 166 : (2SAEZ)-4-\( allyloxy iminol-N-(2.1 ,3-benzothiadiazol-4-ylV 1 -fdiphenylace- tyl)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2,l,3-benzothiadiazol-4-amine the title compound was obtained in 46% purity by LC/MS. MS(ESI+): m/z = 512.4. Example 167: (2S,4EZ -4-(ethoxyimino -N-r9-ethyl-9H-carbazol-3-vn-l-f(2-oxo-6-pentyl- 2H-pyran-3-yl carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pynolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 75% purity by LC/MS. MS(ΕSI+): m/z = 557.4. Example 168: (2S.4EZ)-l-benzoyl-4-(ethoxyimino)-N-('9-ethyl-9H-carbazol-3-yl)-2-ρyrro- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and 9-ethyl- 9H-carbazol-3 -amine the title compound was obtained in 74% purity by LC/MS. MS(ΕSI+): m/z = 469.4. Example 169: r2S,4EZ)-4-rethoχyimino)-N-r9-ethyl-9H-carbazol-3-yl)-l-(methoxyacetvn-2- pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pynolidinecarboxylic acid, methoxyacetyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 88% purity by LC/MS. MS(ΕSI+): m/z = 437.2. Example 170: f2S,4EZ)-4-r(benzyloxy iminol-N 2 -(9-ethyl-9H-carbazol-3-ylVN 1 -pentyl-1.2- pynolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 9- ethyl-9H-carbazol-3-amine the title compound was obtained in 63% purity by LC/MS. MS(ESI+): m/z = 540.4. Example 171 : (3EZ,5S)-l-benzoyl-5-{[4-(3.4-dichlorophenyl)-l-piperazinyl]carbonyl}-3- pynolidinone O-ethyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pynolidinecarboxylic acid, benzoyl chloride, and l-(3,4- dichlorophenyl)piperazine the title compound was obtained in 51% purity by LC/MS. MS(ΕSI+): m/z = 489.6. Example 172: (2S.4EZ)-4-r( " allyloxy imino]-N-(9-ethyl-9H-carbazol-3-yl -l-[(2-oxo-6-pentyl- 2H-pyran-3-yl)carbonvn-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η- pyran-3 -carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 48% purity by LC/MS. MS(ΕSI+): m/z = 569.4. Example 173: (2S.4EZ)-4-{r(4-methoxybenzyl)oxy imino}-N-( ' 2-methoxyethyl)-2-pyrrolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pynolidinecarboxylic acid, and 2- methoxyethylamine the title compound was obtained in 52% purity by LC/MS. MS(ΕSI+): m/z = 322.2. Example 174: (2S,4EZ)-4-r(allyloxy imino1-N-r3.4-dimethoxybenzylVl-( ' diphenylacetyl -2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]- 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 63% purity by LC/MS. MS(ESI+): m/z = 528.4. Example 175 : (2S,4EZ)-4-r(allyloxy imino]- 1 -(4-cvanobenzoylVN-(9-ethyl-9H-carbazol-3- yl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]- 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 43% purity by LC/MS. MS(ΕSI+): m z = 506.4. Example 176: (2S.4EZV4- (r(4-methoxybenzyl)oχy]iminol - 1 -r(2-oxo-6-ρentyl-2H-pyran-3- yl carbonyl]-N-(6-quinolinyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- { [(4-methoxybenzyl)oxy]imino } -2-pyrrolidinecarboxylic acid, 2-oxo-6- ρentyl-2H-pyran-3-carbonyl chloride, and 6-quinolinamine the title compound was obtained in 61% purity by LC/MS. MS(ΕSI+): m/z = 583.4. Example 177: (2S,4EZ -N-(9-ethyl-9H-carbazol-3-ylli-4-(methoxyimino)-2-ρyrrolidinecar- boxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-ρyrrolidinecarboxylic acid, and 9-ethyl-9Η-carbazol-3- amine the title compound was obtained in 46%) purity by LC/MS. MS(ΕSI+): m/z = 351.2. Example 178: ( • 2S.4EZ)-N 2 -(9-ethyl-9H-carbazol-3-vn-4-(methoxyimino -N 1 -(3-methoxy- phenyl)- 1 ,2-pyrrolidinedicarboxarnide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 1 -isocyanato-3- methoxybenzene, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 500.4. Examρle l79: (2S,4EZ)-4-(ethoxyiminoVN 2 -(9-ethyl-9H-carbazol-3-vn-N 1 -(3-methoxy- phenvD- 1 ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, 1 -isocyanato-3-mefhoxy- benzene, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 60% purity by LC/MS. MS(ΕSI+): m/z = 514.4. Example 180: (2S,4EZ)-l- (4-chlorophenoxy)acetvn-4-refhoxyimino)-N-(9-ethyl-9H- carbazol-3-yl -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, (4-chlorophenoxy)acetyl chloride, and 9-ethyl-9H-carbazol-3 -amine the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 533.4. Example 181: (2S,4EZ -4-r(allyloxy imino1-N-r9-ethyl-9H-carbazol-3-vn-l-r4-phenoxy- benzoyl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino] - 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 63% purity by LC/MS. MS(ΕSI+): m z = 573.4. Example 182: (2S,4EZ)-N 1 -benzoyl-N 2 -(9-ethyl-9H-carbazol-3-yl)-4-(methoxyimino)- 2- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, benzoyl isocyanate, and 9- ethyl-9Η-carbazol-3-amine the title compound was obtained in 59% purity by LC/MS. MS(ΕSI+): m/z = 498.4. Example l83: f2S.4EZ)-4-r(benzyloxy minol-N-(9-ethyl-9H-carbazol-3-yl -l-[( ' 2-oxo-6- pentyl-2H-pyran-3-yl)carbonyl1-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 93% purity by LC/MS. MS(ΕSI+): m/z = 619.6. Example 184: r2S.4EZ)-l-acetyl-4-( ' ethoχyimino -N-(9-ethyl-9H-carbazol-3-ylV2-ρvnoli- dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, acetyl chloride, and 9-ethyl- 9Η-carbazol-3-amine the title compound was obtained in 87% purity by LC/MS. MS(ESI+): m/z = 407.2. Example 185: r2S.4EZ)-l-(ri.r-biphenyl]-4-ylcarbonylV4-(ethoxyimino -N-(9-ethyl-9H- carbazol-3-yl -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pynolidinecarboxylic acid, [ 1 , 1' -biphenyl] -4-carbonyl chloride, and 9-ethyl-9H-carbazol-3 -amine the title compound was obtained in 70% purity by LC/MS. MS(ΕSI+): m/z = 545.4. Example 186: (2S.4EZ)-l-acetyl-N-(9-ethyl-9H-carbazol-3-ylV4-(methoχyimino -2-ρyrroli- dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, acetyl chloride, and 9-ethyl- 9Η-carbazol-3-amine the title compound was obtained in 69% purity by LC/MS. MS(ΕSI+): m/z = 393.2. Example 187: (2S,4EZ)-l-(diphenylacetylVN-r9-ethyl-9H-carbazol-3-yl)-4-(methoxyiminoV 2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, diphenylacetyl chloride, and 9- ethyl-9H-carbazol-3-amine the title compound was obtained in 77% purity by LC/MS. MS(ΕSI+): m/z = 545.4. Example 188: (2S,4EZ)-4-r(allyloχy imino1-N 1 -benzoyl-N 2 -(9-ethyl-9H-carbazol-3-yl)- 2- pynolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, benzoyl isocyanate, and 9- ethyl-9H-carbazol-3 -amine the title compound was obtained in 63% purity by LC/MS. MS(ΕSI+): m/z = 524.4. Example 189: C2S.4EZ)-N 2 -(9-ethyl-9H-carbazol-3-yl)-4-(methoxyimino -N 1 -( ' 3-methylphe- nvD- 1 ,2-p yrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 1 -isocyanato-3-methylben- zene, and 9-ethyl-9Η-carbazol-3 -amine the title compound was obtained in 89% purity by LC/MS. MS(ΕSI+): m z = 484.4. Example 190: (2SAEZ)-4- ( ff 4-methoxybenzvnoxylimino I -N 1 -pentyl-N 2 -(2-thienylmethylV 1 ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4- { [(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, 1 - isocyanatopentane, and 2-thienyhnethylamine the title compound was obtained in 86% purity by LC/MS. MS(ΕSI+): m/z = 473.2. Example 191 : (2S,4EZ)-4-(ethoxyimino -l-(methoxyacetyl)-N-(6-quinolinyl ' )-2-pyrrolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pynolidinecarboxylic acid, methoxyacetyl chloride, and 6-quinolinamine the title compound was obtained in 81% purity by LC/MS. MS(ΕSI+): m/z = 371.2. Example 192: (2S.4EZ)-4-r( ' allyloxy imino1-N-( ' 9-ethyl-9H-carbazol-3-ylV2-pyrrolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, and 9-ethyl-9H- carbazol-3-amine the title compound was obtained in 80% purity by LC/MS. MS(ΕSI+): m/z = 377.2. Example 193: ( " 2S,4EZ -4-r(benzyloxy')imino]-l- ( ' 2-oxo-6-pentyl-2H-pyran-3-yl)carbonyll-N- ( ' 6-quinolinyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and 6-quinolinamine the title compound was obtained in 48% purity by LC MS. MS(ΕSI+): m/z = 553.4. Example 194: (2S,4EZ)-4-[(allyloxy)imino]-N-[2-(diethylamino ethyl]-2-pyrrolidinecarbox- amide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, and Νl,Νl-diethyl- 1,2-ethanediamine the title compound was obtained in 78% purity by LC/MS. MS(ΕSI+): m/z = 283.0. Example l95: (2S.4EZ -l-r4-rdimethylamino>butanoyll-N-f9-ethyl-9H-carbazol-3-vn-4- (methoxyimino)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyπOlidinecarboxylic acid, 4-(dimethylamino)-butanoyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 42% purity by LC/MS. MS(ΕSI+): m/z = 464.2. Example 196: (2S)-2-[(3-hydroxy-l-azetidinyl carbonyl]-N-(3-methoxyphenyl -4-oxo-l- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-oxoproline, l-isocyanato-3-methoxybenzene, and 3-azetidinol the title compound was obtained in 87% purity by LC/MS. MS(ESI+): m/z = 334.2. Example 197: r2S.4EZ)-4-[(benzyloxy imino]-N-(9-ethyl-9H-carbazol-3-yl -l-(phenoxyace- tyl -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 65% purity by LC/MS. MS(ΕSI+): m/z = 561.4. Example 198: (2S -N-(9-ethyl-9H-carbazol-3-yl -4-methylene-l -[(2-oxo-6-pentyl-2H-pyran- 3-yl)carbonyl]-2-pwolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, 2-oxo-6-pentyl-2Η-pyran-3-carbonyl chloride, and 9-ethyl-9H- carbazol-3 -amine the title compound was obtained in 70% purity by LC/MS. MS(ESI+): m/z = 512.4. Example 199: (2S,4EZ)-N-(9-ethyl-9H-carbazol-3-yl)-l -(methoxyacetyl)-4-fmethoχyimino)- 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, methoxyacetyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 73% purity by LC/MS. MS(ΕSI+): m/z = 423.4. Example 200: S^EZ^-^-Cg-ethyl-gH-carbazol-S-vD^-toethoxyimino N 1 -pentyl- 2- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 1-isocyanatopentane, and 9- ethyl-9H-carbazol-3-amine the title compound was obtained in 81% purity by LC/MS. MS(ΕSI+): m/z = 464.2. Example 201: (2S,4EZ)-4-(ethoxyiminoVN 1 -pentyl-N 2 -r2-riH-ρynol-l-yl phenyl1- 2- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 2- (lΗ-pyrrol-l-yl)phenylamine the title compound was obtained in 83% purity by LC/MS. MS(ΕSI+): m/z = 426.2. Example 202: (2S.4EZ)-4-[(allyloxy)iminol-N-(2-methoxyethyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, and 2- methoxyethylamme the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 242.0. Example 203 : ( " 2S,4EZ)-4-(tert-butoxyimino -N 2 -(2-methoχyethvn-N 1 -(3-methoχyphenyl - 1 ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(tert-butoxyimino)-2-pynolidinecarboxylic acid, l-isocyanato-3 -methoxy- benzene, and 2-methoxyethylamine the title compound was obtained in 76% purity by LC/MS. MS(ESI+): m/z = 407.2. Example 204: ( , 2S,4EZ)-4-r(allyloxy imino]-N 2 -(2-methoχyethyl -N 1 -(3-methylρhenyl -1.2- pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino] - 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 1 -isocyanato-3 - methylben-zene, and 2-methoxyethylamine the title compound was obtained in 85% purity by LC/MS. MS(ΕSI+): m/z = 375.2. Example 205 : (2S,4EZ -i-benzoyl-4-benzylidene-N-(9-ethyl-9H-carbazol-3-yl -2-pyrroli- dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and 9-ethyl-9Η- carbazol-3-amine the title compound was obtained in 81% purity by LC/MS. MS(ΕSI+): m/z = 500.4. Example 206: (2S,4EZ)-N 2 -benzyl-4-benzylidene-N 2 -methyl-N 1 -(3-methylphenylV 2- pynolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene-l-(tert-butoxycarbonyl)-2-pynolidinecarboxylic acid, l-isocyanato-3-methylbenzene, and Ν-benzyl-Ν-methylamine the title compound was obtained in 68% purity by LC/MS. MS(ΕSI+): m z = 440.2. Example 207: (2S,4EZ)-4-(ethoxyimino -N-(9-ethyl-9H-carbazol-3-vn-l-(4-phenoxybenzoyl - 2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and 9-efhyl-9H-carbazol-3-amine the title compound was obtained in 99% purity by LC/MS. MS(ESI+): m z = 561.4. Example 208: (2S.4EZ)-4-(ethoxyimino)-N 2 -(9-ethyl-9H-carbazol-3-yn-N 1 -(3-methylphenyl - 1 ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, 1 -isocyanato-3 -methylben-zene, and 9-ethyl-9Η-carbazol-3 -amine the title compound was obtained in 80% purity by LC/MS. MS(ΕSI+): m/z = 498.4. Example 209: (2S,4EZ)-4-(methoχyimino)-l-(ρhenoxyacetyl)-N-(6-quinolinyl -2-pynoli- dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, phenoxyacetyl chloride, and 6- quinolinamine the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 419.2. Example 210: (2S.4EZ)-4-(tert-butoxyimino -N-(3,4-dimethoxybenzylVl-[r2-oxo-6-ρentyl- 2H-pyran-3-yl)carbonyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(tert-butoxyimino)-2-pynolidinecarboxylic acid, 2-oxo-6-pentyl-2Η- pyran-3 -carbonyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 63% purity by LC/MS. MS(ΕSI+): m z = 542.4. Example 211: (2S,4EZ)-4-(tβrt-butoxyimino)-N-cvclopropyl-l-(phenoxyacetyl -2-pyrrolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and cyclopropylamine the title compound was obtained in 73% purity by LC/MS. MS(ESI+): m z = 374.2. Example 212: (2S.4EZ)-4-[(benzyloxy imino]-N-(tert-butyl - 1 -(phenoxyacetyl -2-pyno- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and tert-butylamine the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 424.2. Example 213: (2S,4EZ)-N-(4,6-dimethoxy-2-ρyrimidinyl)-4-(ethoxyimino -l-(4-phenoxy- benzoyl -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-ρynolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and 4,6-dimethoxy-2-pyrimidinarnine the title compound was obtained in 79% purity by LC/MS. MS(ΕSI+): m/z = 506.4. Example 214: (4ZE)-4-rfallyloxy)imino1-N-(9-ethyl-9H-carbazol-3-yl -l-(ρhenoxyacetyl -2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino] - 1 -(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 63% purity by LC/MS. MS(ESI+): m/z = 511.4. Example 215: (2S,4EZ)-l-(π J'-biρhenyl]-4-ylcarbonvn-N-(9-ethyl-9H-carbazol-3-vn-4- (methoxyimino)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 66% purity by LC/MS. MS(ESI+): m/z = 531.4. Example 216: (3EZ,5S)-l-[4-(dimethylamino)butanovn-5-(l-piperidinylcarbonyl -3-pyrro- lidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 4-(dimethylamino)butanoyl chloride, and piperidine the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 339.2. Example 217: (2S.4EZ)-l-acetoacetyl-N-(9-ethyl-9H-carbazol-3-yl -4-(methoxyimino -2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2,4-oxetanedione, and 9- ethyl-9Η-carbazol-3-amine the title compound was obtained in 42% purity by LC/MS. MS(ΕSI+): m/z = 435.2. Example 218: (2S.4EZ -4-(methoxyimino)-l -r(2-oxo-6-pentyl-2H-ρyran-3-vncarbonyll-N-(6- quinolinyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and 6-quinolinamine the title compound was obtained in 57% purity by LC/MS. MS(ΕSI+): m/z = 477.2. Example 219: (2S,4EZ)-N-(9-ethyl-9H-carbazol-3-vn-4- r(4-methoxybenzyl oxy1imino)-l- [(2-oxo-6-pentyl-2H-pyran-3-yl carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but~ oxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 2-oxo-6- pentyl-2H-pyran-3-carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 57% purity by LC/MS. MS(ESI+): m/z = 649.4. Example 220: f2S,4EZ)-N 2 -allyl-N 1 -benzoyl-4-(methoxyimino -l ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, benzoyl isocyanate, and allylamine the title compound was obtained in 49% purity by LC/MS. MS(ΕSI+): m/z = 345.0. Example 221 : (2S.4EZ)-4-r(benzyloxy iminol-N-( ' 9-ethyl-9H-carbazol-3-vD-l-(methoxy- acetyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, methoxyacetyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 46% purity by LC/MS. MS(ΕSI+): m/z = 499.2. Example 222: (ΣS^EZ^-N^fS^-dichlorophenyl ^-Cg-ethyl-gH-carbazol-S-vn^-toethoxy- imino)-l,2-pynolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1 ,3-dichloro-5-isocyanato- benzene, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 42% purity by LC/MS. MS(ΕSI+): m/z = 538.2. Example 223: (2S.4EZ)-N-(9-ethyl-9H-carbazol-3-yl -4-(methoχyimino -l-(4-ρhenoxyben- zoyl -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 43% purity by LC/MS. MS(ESI+): m/z = 547.2. Example 224: (2SAEZ)-N l -(3,5-dichlorophenylV4-f ethoxyiminoVN 9-ethyl-9H-carbazol-3- ylVl .2-pynolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyιτolidinecarboxylic acid, 1 ,3-dichloro-5-isocyanato- benzene, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 43% purity by LC/MS. MS(ΕSH-): m/z = 552.6. Example 225: (3EZ,5S -5-{[4-( 3-benzodioxol-5-ylmethyl -l-piρerazinyllcarbonvU-l-rr2- oxo-6-pentyl-2H-pyran-3-yl carbonyl]-3-pyrrolidinone O-(tert-butyl oxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η- pyran-3-carbonyl chloride, and l-(l,3-benzodioxol-5-ylmethyl)piperazine the title compound was obtained in 59% purity by LC/MS. MS(ΕSI+): m/z = 595.4. Example 226: (2S,4EZ)-4-benzylidene-N-(9-ethyl-9H-carbazol-3-yl)- 1 -r(2-oxo-6-pentyl-2H- pyran-3-yl carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene- 1 -(tert-butoxycarbonyl)-2-pynolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 47% purity by LC/MS. MS(ΕSI+): m/z = 588.4. Example 227: (2£4EZ -4-[(allyloxy imino]- 1 -benzoyl-N-(6-quinolinyl -2-pyrrolidinecarbox- amide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and 6-quinohnamine the title compound was obtained in 83% purity by LC/MS. MS(ΕSI+): m/z = 415.2. Example 228: (2S.4EZ)-4-r(allyloχy imino1-l -fmethoxyacetyl)-N- 6-quinolinyl)-2-pyrroli- dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l -(tert-butoxycafbonyl)-2-pyrrolidinecafboxylic acid, methoxyacetyl chloride, and 6-quinolinamine the title compound was obtained in 71% purity by LC/MS. MS(ΕSI+): m/z = 383.0. Example 229: r2S.4EZ)-4-rrallyloxy iminol-N-( " 9-ethyl-9H-carbazol-3-yl -l-rmethoxyacetyl)- 2-pyrrolidinecaτboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pynolidinecarboxylic acid, methoxyacetyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 74% purity by LC/MS. MS(ΕSI+): m/z = 449.2. Example 230: f2S,4EZ)-4-[(allyloxy iminol-l-r2-ethoxy-l-naphthoyl)-N-(9-ethyl-9H-carba- zol-3-yl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino] - 1 -(tert-butoxycarb.onyl)-2-pyrrolidinecarboxylic acid, 2-ethoxy- 1 - naphthoyl chlo-ride, and 9-ethyl-9Η-carbazol-3 -amine the title compound was obtained in 60% purity by LC/MS. MS(ΕSI+): m/z = 575.4. Example 231: ( , 2S,4EZ)-4-r(allyloxy imino1-l-rr4-chloroρhenoxy)acetyl1-N-(9-ethyl-9H- carbazol-3-yiy 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, (4- chlorophenoxy)acetyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 78% purity by LC/MS. MS(ΕSI+): m/z = 545.4. Example 232: (2S,4EZ)-4-[(allyloxy imino]-l-f [1.1 '-biphenyl] -4-ylcarbonyl -N-(9-ethyl-9H- carbazol-3-yl -2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pynolidinecarboxylic acid, [1 ,1 '-biphenyl]-4- carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 51% purity by LC/MS. MS(ΕSI+): m/z = 557.2. Example 233 : (2S.4EZ -4-[( , allyloxy imino]-l -rdiphenylacetyl -N-(9-ethyl-9H-carbazol-3-ylV 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4- [(allyloxy)-imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 9-ethyl-9Η-carbazol-3-amine the title compound was obtained in 43% purity by LC/MS. MS(ΕSI+): m/z = 571.2. Example 234: (2S.4EZ -l-(r r-biphenyl]-4-ylcarbonyl -N-(tert-butyl -4-(chloromethylene - 2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, [1 ,1 ' -biphenyl] -4-carbo-nyl chloride, and tert-butylamine the title compound was obtained in 80% purity by LC/MS. MS(ΕSI+): m/z = 397.6. Example 235: tert-butyl 3-[({4-methylene-l-[(pentylamino carbonyl]-2-pyrrolidiny car- bonyl amino]-l-azetidinecarboxylate Following the general method as outlined in Example 22, starting from l-(tert-butoxy- carbonyl)-4-methyleneproline, 1-isocyanatopentane, and tert-butyl 3-amino-l-azetidine- carboxylate the title compound was obtained in 75% purity by LC/MS. MS(ESI+): m/z = 395.2. Example 236: (3EZ,5S -l-acetyl-5-[(4-acetyl-l-piperazinyl carbonyl]-3-pyrrolidinone O-(3.4- dichlorobenzvDoxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-ρynolidinecarboxylic acid, acetyl chloride, and 1-acetylpiperazine the title compound was obtained in 85% purity by LC/MS. MS(ΕSI+): m/z = 455.2. Example 237: (2S,4EZ -N 2 -benzyl-4-(methoxyimino -N 1 -pentyl-l ,2-pyrrolidinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and benzylamine the title compound was obtained in 100% purity by LC/MS. MS(ΕSI+): m/z = 361.0. Example 238: (2SAEZ)- 1 -acetyl-4- tf(3.4-dichlorobenzyl oxy]imino) -N-d -naphthylmethyl - 2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pynolidinecarboxylic acid, acetyl chloride, and 1-naphthylmethylamine the title compound was obtained in 60% purity by LC/MS. MS(ΕSI+): m/z = 484.2. Example 239: (2S,4EZ)-4-(tert-butoxyimino -N-cyclopropyl-l -[(2-oxo-6-pentyl-2H-pyran-3- yl)carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η- pyran-3 -carbonyl chloride, and cyclopropylamine the title compound was obtained in 75% purity by LC/MS. MS(ΕSI+): m/z = 432.2. Example 240: (2S.4EZ)-4-{r(4-methoxybenzyl oxylimino}-l-( ' 4-ρhenoxybenzoyl -N-[2-(lH- pyrrol-l-yltphenyll-Σ-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, 4-phenoxy- benzoyl chloride, and 2-(lH-pyrrol-l-yl)phenylamine the title compound was obtained in 55% purity by LC/MS. MS(ΕSI+): m/z = 601.4. Example 241 : (2S)-N-(1 ,3-benzodioxol-5-ylmethyl -4-oxo-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-oxoproline, and l,3-benzodioxol-5-ylmethylamine the title compound was obtai-ned in 71% purity by LC/MS. MS(ESI+): m/z = 263.0. Example 242: (2SAEZ)-N-(l -benzodioxol-5-ylmethyl)-l -d 1.1 '-biρhenvn-4-ylcarbonyl)-4- (chloromethylene)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbo-nyl chloride, and l,3-benzodioxol-5-ylmethylamine the title compound was obtained in 63% purity by LC/MS. MS(ΕSI+): m/z = 475.6. Example 243: r2S.4EZ)-N-(3,4-dimethoxybenzylV4-( ' ethoxyiminoVl-r(2-oxo-6-pentyl-2H- pyran-3-yl carbonyl]-2-pwolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-pyran-3- carbonyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 41% purity by LC/MS. MS(ΕSI+): m/z = 514.2. Example 244: (2S)-2-[(3-hydroxy-l-azetidinyl carbonyl]-N-(3-methylphenyl)-4-oxo-l-pynoli- dinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-oxoproline, l-isocyanato-3 -methylbenzene, and 3-azetidinol the title compound was obtained in 73% purity by LC/MS. MS(ESI+): m/z = 318.0. Example 245: (2S.4EZ)-4-r(benzyloχy imino]-N-r(2RS)-2-hvdroxy-2-phenethyl1-l-r(2-oxo-6- pentyl-2H-pyran-3-yl carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2H-pyran-3- carbonyl chloride, and (lRS)-2-amino-l-phenylethanol the title compound was obtained in 55% purity by LC/MS. MS(ΕSI+): m/z = 546.2. Example 246: (2S,4EZ)-4-r(allyloχy imino]-N 2 -(3.4-dimethoχybenzyl -N 1 -(3-methoχy- phenyD- 1 ,2-ρ yπoridinedicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-ρyrrolidinecarboxylic acid, l-isocyanato-3 -methoxy- benzene, and 3,4-dimethoxybenzylamine the title compound was obtained in 97% purity by LC/MS. MS(ΕSI+): m/z = 483.2. Example 247: (2S,4EZ)-4-[(allyloxy iminol-l-(4-cyanobenzoyl -N-(2-methoxyethyl -2- pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 2-methoxyethylamine the title compound was obtained in 44% purity by LC/MS. MS(ΕSI+): m/z = 371.0. Example 248 : (2S,4EZ)-N-benzyl- 1 -(methoxyacetyl)-4- { [(4-methoxybenzyl oxy]imino} -2- pynolidine-carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4- { [(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, methoxyacetyl chloride, and benzylamine the title compound was obtained in 49% purity by LC/MS. MS(ΕSI+): m/z = 426.2. Example 249: (2SAEZ)-1 -benzoyl-4-(chloromethylene -N-(2-furylmethyl -2-pynolidinecar- boxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-ρyrrolidinecarboxylic acid, benzoyl chloride, and 2- furylmethylamine the title compound was obtained in 73% purity by LC/MS. MS(ΕSI+): m/z = 345.6. Example 250: (2S -l-acetyl-4-methylene-N-(6-quinolinyl ' )-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, acetyl chloride, and 6-quinolinamine the title compound was obtained in 87% purity by LC/MS. MS(ESI+): m/z = 296.0. Example 251 : (2S.4EZ -l-acetyl-4-{r(3 -dichlorobenzvnoxyliminol-N-(2-furylmethylV2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidmecarboxylic acid, acetyl chloride, and 2-furylmethylamine the title compound was obtained in 199% purity by LC/MS. MS(ΕSI+): m/z = 424.6. Example 252: (2S)-N l -( 3.5-dichlorophenyl -4-methylene-N -(6-quinolinyl)- 2- pyrrolidinedicar-boxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxy-car- bonyl)-4-methyleneproline, l,3-dichloro-5-isocyanatobenzene, and 6-quinolinamine the title compound was obtained in 65% purity by LC/MS. MS(ESI+): m/z = 441.0. Example 253: (3EZ,5S)-l-(diphenylacetyl -5-(l-piperidinylcarbonyl -3-pyrrolidinone O-(4- methoxybenzyDoxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- { [(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, diphenyl- acetyl chloride, and piperidine the title compound was obtained in 87% purity by LC/MS. MS(ESI+): m/z = 526.4. Example 254: (2S,4EZ)-4-(chloromethyleneVN-d -naphthylmethylVl-(phenoxyacetyl -2- pyrrolidine-carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 1-naphthylmethylamine the title compound was obtained in 75% purity by LC/MS. MS(ΕSI+): m/z = 435.6. Example 255: (2S,4EZ)-4-[(allyloxy imino]-N-benzoyl-2-(4-morpholinylcarbonyl -l-pyrro- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pynolidinecarboxylic acid, benzoyl isocyanate, and morpholine the title compound was obtained in 46% purity by LC/MS. MS(ΕSI+): m/z = 401.2. Example 256: (2S,4EZ)-N 1 -benzoyl-4-(chloromethylene -N 2 -cyclopropyl-l ,2-pyrrolidine- dicarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, benzoyl isocyanate, and cyclopropylamine the title compound was obtained in 76% purity by LC/MS. MS(ΕSI+): m/z = 348.6. Example: 257: (2S,4EZ)-4-{[( " 3.4-dichlorobenzyl)oxy1imino>-l-(methoxyacetyl)-N-(l- naphthylmethyl -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, methoxyacetyl chloride, and 1-naphthylmethylamine the title compound was obtained in 91% purity by LC/MS. MS(ESI+): m/z = 514.8. Example 258: (2SAEZ)- 1 -benzoyl-N-benzyl-4-(chloromethylene -N-methyl-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(chloromethylene)-2-pynolidinecarboxylic acid, benzoyl chloride, and Ν- benzyl-Ν-methylamine the title compound was obtained in 62% purity by LC/MS. MS(ΕSI+): m/z = 369.4. Example 259: (2S)-N 9 -(2-furylmethyl -N 1 -(3-methoxyphenyl -4-methylene-l,2-pyrrolidinedi- carboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, l-isocyanato-3-methoxybenzene, and 2-furylmethylamine the title compound was obtained in 95% purity by LC/MS. MS(ESI+): m/z = 356.0. Example 260: (3EZ.5S)-5-[(4-benzhydryl-l-piperazinyl carbonyl]-l-(ρhenoxyacetyl)-3- pyrrolidinone O-ethyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(ethoxyimino)-2-pynolidinecarboxylic acid, phenoxyacetyl chloride, and 1-benzhydrylpiperazine the title compound was obtained in 67% purity by LC/MS. MS(ΕSI+): m/z = 541.2. Example 261: (3EZ,5S)-l-benzoyl-5-(4-morpholinylcarbonyl)-3-pynolidinone O-(3,4- dichlorobenzvD-oxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, benzoyl chloride, and morpholine the title compound was obtained in 69% purity by LC MS. MS(ΕSI+): m/z = 476.2. Example 262: (2S)-N 1 -(3-methoxyphenylV4-methylene-N 2 -(l-naρhthylmethylV1.2- pyrrolidine-dicarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxy- carbonyl)-4-methyleneproline, l-isocyanato-3-methoxybenzene, and 1-naphthylmethyl-amine the title compound was obtained in 55% purity by LC/MS. MS(ESI+): m/z = 416.3. Example 263: N -(2-methoxyethyl -4-methylene-N -(3-methylphenyl)- 2-pyrrolidinedi- carboxamide Following the general method as outlined in Example 22, starting from l-(ter/-butoxycar- bonyl)-4-methyleneproline, l-isocyanato-3 -methylbenzene, and 2-methoxyethylamine the title compound was obtained in 85% purity by LC/MS . MS(ESI+) : m/z = 318.0. Example 264: (2S,4EZ)-N-allyl-4-{[(4-methoxybenzyl oxylimino>-l-(phenoxyacetyl)-2- pyreoridinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino} -2-pynolidinecarboxylic acid, phenoxy- acetyl chloride, and allylamine the title compound was obtained in 72% purity by LC/MS. MS(ΕSI+): m z = 438.2. Example 265 : (2SAE22.-1 -benzoyl-4-(cyanomethylene)-N-(l -naρhthylmethyl -2-pyrrolidine- carboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, benzoyl chloride, and 1- naphthylmethylamine the title compound was obtained in 43% purity by LC/MS. MS(ΕSI+): m/z = 396.0. Example 266: (2S.4EZ -4-(r(3,4-dichlorobenzvnoxylimino>-l-r(2-oxo-6-ρentyl-2H-pyran-3- yl carbonyl1-N-(6-quinolinyl -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4- { [(3,4-dichlorobenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, 2-oxo-6- pentyl-2H-pyran-3 -carbonyl chloride, and 6-quinolinamine the title compound was obtained in 70% purity by LC/MS. MS(ESI+): m/z = 621.2. Example 267 : (2S.4EZ -N- 2-(diethylamino ethyl]- 1 -[4-f dimethylamino butanoyl]-4- { [Y4- methoxybenzyl)oxy]imino}-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4- {[(4-methoxybenzyl)oxy]imino} -2-pyrrolidinecarboxylic acid, 4- (dimethylamino)butanoyl chloride, and Ν1,Ν1 -diethyl- 1,2-ethanediamine the title compound was obtained in 100% purity by LC/MS. MS(ESI+): m/z = 476.2. Example 268: (2S,4EZ)-4-f( ' allyloxy iminol-l-r4-( , dimethylamino)butanoyl]-N-α -naphthyl- methyl)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-(dimethylamino)buta-noyl chloride, and 1-naphthylmethylamine the title compound was obtained in 85% purity by LC/MS. MS(ΕSI+): m/z = 437.2. Example 269: (2S,4EZ)-N-r2-(diethylamino)ethyl]-4-(ethoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, and Νl ,Ν1 -diethyl- 1,2- ethanediamine the title compound was obtained in 70% purity by LC/MS. MS(ΕSI+): m/z = 271.0. Example 270: (2S -4-methylene-l-r(2-oxo-6-ρentyl-2H-ρyran-3-yl carbonvn-N-(6- quinolinyl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from l-(tert-butoxycar- bonyl)-4-methyleneproline, 2-oxo-6-pentyl-2H-pyran-3 -carbonyl chloride, and 6-quinolinamine the title compound was obtained in 48% purity by LC/MS. MS(ESI+): m/z = 446.2. Example 271 : (2S,4EZ)-l-acryloyl-N-allyl-4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, acryloyl chloride, and allylamine the title compound was obtained in 81% purity by LC/MS. MS(ΕSI+): m/z = 252.0. Example 273: tert-butyl 3-({[(2S,4EZ)-l-acetyl-4-benzylidenepyrrolidinyl]carbonyl>amino)- 1 -azetidinecarboxylate Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-benzyli- dene-l-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, acetyl chloride, and tert-butyl 3- amino-1 -azetidinecarboxylate the title compound was obtained in 81% purity by LC/MS. MS(ΕSI+): m/z = 400.2. Example 273: ( , 2S,4EZ)-4-r(allyloxy)imino1-l-r(2-oxo-6-pentyl-2H-ρyran-3-yl)carbonyn-N- (6-quinolinyl)-2-pyrroli dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyl- oxy)imino]-l-(tert-butoxycarbonyl)-2-pynolidinecarboxylic acid, 2-oxo-6-pentyl-2Η-ρyran-3- carbonyl chloride, and 6-quinolinamine the title compound was obtained in 67% purity by LC/MS. MS(ΕSI+): m/z = 503.2. Example 274: (2S,4EZ)-4-(ethoxyimino -N-(l-naphthylmethyl -l-(phenoxyacetyl -2-pyno- lidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert-but- oxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 1- naphthylmethylamine the title compound was obtained in 85% purity by LC/MS. MS(ΕSI+): m/z = 446.3. Example 275 : (2S,4EZ)-N-r(2RS)-2-hvdroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[( ' 2'- methyl [1,1 '-biphenyl] -4-yl carbonyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[ 1 , 1 '-biphenyl]-4- carboxylic acid, and (lRS)-2-amino-l-phenylethanol, the title compound was obtained in 96.4 % purity by HPLC. MS(ΕSI+): m/z = 472. Example 276: (2S,4EZ)-l-(r r-biphenyll-3-ylcarbonyl -N-r(2RS)-2-hvdroxy-2-phenylethyll- 4-(methoχyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -3 -carboxylic acid, and (lRS)-2-amino-l-phenylethanol, the title compound was obtained in 72 % purity by HPLC. MS(ESI+): m/z = 458. Example 277: (2S.4EZ)-l-(4-benzoylbenzoyl -N-[(2RS -2-hvdroxy-2-phenylethyll-4- (methoxyimino -2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 4-benzoylbenzoic acid, and (lRS)-2-amino-l-ρhenylethanol, the title compound was obtained in 93 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 278 : (2S.4EZ)-N-[(2RS -2-hydroxy-2-phenylethvn-4-fmethoxyimino)-l -(3- phenoxybenzoyl -2-pyrroli dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 3-phenoxybenzoic acid, and (lRS)-2-amino-l-phenylefhanol, the title compound was obtained in 94 % purity by HPLC. MS(ΕSI+): m/z = 474. Example 279: (2S.4EZ)-N-r(2RS)-2-hvdroxy-2-phenylethyn-4-(methoxyimino -l-(2- ρhenoxybenzoyl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2-phenoxybenzoic acid, and (lRS)-2-amino- 1 -phenylethanol, the title compound was obtained in 92 % purity by HPLC. MS(ΕSI+): m/z = 474. Example 280: (2S.4EZ)-N-[(2S)-2-hvdroxy-2-ρhenylethyl]-4-(methoxyimino)-l- ( ' 2'- mefhvir 1 , 1 '-biphenyl]-4-yl carbonyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l, -biphenyl]-4- carboxylic acid, and (lS)-2-amino-l-ρhenylethanol, the title compound was obtained in 98 % purity by HPLC. MS(ESI+): m/z = 472. Example 281 : (2S.4EZ)-N-r(2RV2-hydroxy-2-phenylethyl]-4-(methoxyimino -l-[(2'- methyl [1,1 '-biphenyl] -4-yl carbonyl] -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l ,l'-biphenyl]-4- carboxylic acid, and (lR)-2-amino-l -phenylethanol, the title compound was obtained in 84 % purity by HPLC. MS(ΕSI+): m/z = 472. Example 282: (2S,4EZ -N-(2-hvdroxyefhvn-4-(methoxyiminoVl-[(2'-methyl[lJ'-biphenyl1-4- yl carbonyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and 2-aminoefhanol, the title compound was obtained in 75 % purity by HPLC. MS(ΕSI+): m/z = 396. Example 283: (2S,4EZ)-N-r2-hydroxyethylV4-rmethoxyimino -N-methyl-l-rr2'-methvirLl'- biphenyl1-4-yl carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l ,1 '-biphenyl]-4- carboxylic acid, and 2-(methylamino)efhanol, the title compound was obtained in 78 % purity by HPLC. MS(ΕSI+): m/z = 410. Example 284: (2S,4EZ -l-( l,l'-biphenyl1-4-ylsulfonyn-N-r(lS,2S,3R.4RV3- (hydroxymethyDbicyclo [2.2.1 lhept-2-yl] -4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and [(lR,2R,3S,4S)-3-aminobicyclo[2.2.1]hept-2-yl]methanol, the title compound was obtained in 79 % purity by HPLC. MS(ΕSI+): m/z = 498. Example 285: (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl -N-(trαn -4-hvdroxycyclohexyl -4- (methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and traws-4-aminocyclohexanol, the title compound was obtained in 62 % purity by HPLC. MS(ΕSI+): m/z = 436. Example 286: r2S,4EZ)-l-r[l,r-biphenyl]-4-ylcarbonvn-N-rflR.2R)-2- (hydroxymethyl)cyclohexyl]-4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,l'-biphenyl] -4-carbonyl chloride, and [(lR,2R)-2-aminocyclohexyl]methanol, the title compound was obtained in 65 % purity by HPLC. MS(ΕSI+): m/z = 450. Example 287: (2S,4EZ)-l-(π.r-biphenyl]-4-ylcarbonyl -N-[(2RS -2-hydroxy-3- phenoxypropyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (2RS)-l-amino-3-phenoxy-2-propanol, the title compound was obtained in 68 % purity by HPLC. MS(ΕSI+): m/z = 488. Example 288: (2S.4EZ)-N-[(2RS)-2-hydroxy-3-ρhenoχypropyl]-4-(methoχyimino -l-r4-(3- pyridinyl)benzoyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (2RS)-l-amino-3-phenoxy-2-propanol, the title compound was obtained in 76 % purity by HPLC. MS(ΕSI+): m/z = 489. Example 289: (2S.4EZ)-l- i.l'-biphenyll-4-ylsulfonyl)-N-r(2RS -2-hvdroχy-3- phenoxypropyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and (2RS)-l-amino-3-phenoxy-2-propanol, the title compound was obtained in 78 % purity by HPLC. MS(ΕSI+): m/z = 524. Example 290: (2SAEZ)-l-(\l^-biphemll-4-ylcaxhom\)-N-\(2RS)-2-h.ydxoxy-2-(4- hydroxyphenyl ethyl1-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and 4-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 63 % purity by HPLC. MS(ΕSI+): m/z = 474. Example 291 : (2S.4EZ -1-([1 ,r-biphenyll-4-ylsulfonyl -N-r(2RS)-2-hvdroxy-2-(4- hydroxyphenv ethyl]-4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [l,l'-biphenyl] -4-sulfonyl chloride, and 4-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 72 % purity by HPLC. MS(ΕSI+): m z = 510. Example 292: (2SAEZ-l-(\ 1.1 '-biphenyll-4-ylcarbonyl -N-[(l-hvdroxycyclohexyl methyl1-4- (methoxyimino -2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [l,l'-biphenyl]-4-carbonyl chloride, and l-(aminomethyl)cyclohexanol, the title compound was obtained in 65 % purity by HPLC. MS(ΕSI+): m/z = 450. Example 293: (2S,4EZ)-N-r(l-hvdroxycvclohexyl methyl]-4-(methoxyiminoVl-r4-(3- pyridinyl benzoyl1-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and l-(aminomethyl)cyclohexanol, the title compound was obtained in 69 % purity by HPLC. MS(ΕSI+): m/z = 451. Example 294: (2S.4EZ)-l-(ri,l'-biphenyll-4-ylsulfonyl -N-r(l-hydroxycyclohexynmethyll-4- (methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and l-(aminomethyl)cyclohexanol, the title compound was obtained in 66 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 295: (2S,4EZ)-l-(ri,r-biphenyll-4-ylcarbonvn-N-r(2RS -2-(3,4-dihvdroxyphenvn-2- hvdroxyethyll-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1 ,l'-biphenyl]-4-carbonyl chloride, and 4-[(lRS)-2-amino-l-hydroxyethyl]-l,2-benzenediol, the title compound was obtained in 66 % purity by HPLC. MS(ΕSI+): m/z = 490. Example 296: (2S.4EZ)-N-r(2S -2-hydroxy-2-phenylethyll-4-(methoxyimino)- 1 -[4-(4- pyridinyl benzoyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(4-ρyridinyl)benzoic acid, and (lS)-2-amino-l-phenylethanol, the title compound was obtained iii 65 % purity by HPLC. MS(ΕSI+): m/z = 459. Example 297: (2S,4EZ)-N-r(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-f4-(3- pyridinyDbenzoyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (lS)-2-amino-l -phenylethanol, the title compound was obtained in 73 % purity by HPLC. MS(ΕSI+): m/z = 459. Example 298: (2S,4EZ -N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino -l-r4-(2- pyridinyl benzoyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pynolidinecarboxylic acid, 4-(2-pyridinyl)benzoic acid, and (lS)-2-amino-l-phenylethanol, the title compound was obtained in 69 % purity by HPLC. MS(ΕSI+): m/z = 459. Examnle 299: (2SAEZ)-U 1 ,r-biphenyll-4-ylcarbonyl -N-r(2RS)-2,3-dihvdroxypropyl]-4- (methoχyimino)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (2RS)-3-amino-l, 2-propanediol, the title compound was obtained in 73 % purity by HPLC. MS(ΕSI+): m/z = 412. Example 300: (2SAEZ)- \1.l'-biphenvn-4-ylsulfonylVN-r(2RS -2,3-dihvdroxypropyl1-4- (methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimmo)-2-pynolidinecarboxylic acid, [l,l'-biphenyl]-4-sulfonyl chloride, and (2RS)-3-amino-l,2-propanediol, the title compound was obtained in 64 % purity by HPLC. MS(ΕSI+): m/z = 448. Example 301 : (2S,4EZ)-l-([l,l'-biphenyll-4-ylcarbonylVN-r(2RS)-2-hydroxy-3-(4- methoxyphenoxy propyl]-4-(methoxyimino -2-ρyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (2RS)-l-amino-3-(4-methoxyphenoxy)-2-propanol, the title compound was obtained in 81 % purity by HPLC. MS(ΕSI+): m/z = 518. Example 302: (2S,4EZ)-N-r(2RS -2-hvdroχy-3-(4-methoxyρhenoχy propyll-4- (methoxyimino -l-[4-(3-pyridinyl)benzoyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (2RS)-l-amino-3-(4-methoxyphenoxy)-2-propanol, the title compound was obtained in 63 % purity by HPLC. MS(ΕSI+): m/z = 519. Example 303: (2S,4EZ -l-r[l,r-biphenyl]-4-ylsulfonylVN-r(2RS -2-hvdroxy-3-(4- methoxyphenoxy proρyl]-4-fmethoxyiminoV2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and (2RS)-l-amino-3-(4-mefhoxyphenoxy)-2-propanol, the title compound was obtained in 69 % purity by HPLC. MS(ΕSI+): m/z = 554. Example 304: (2SAEZ)- 1 -ff U , -biphenyll-4-ylcarbonvn-N-r(2RS)-2-hvdroxypropyl]-4- (methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (2RS)-l-amino-2-proρanol, the title compound was obtained in 82 % purity by HPLC. MS(ΕSI+): m/z = 396. Example 305: f2S,4EZ)-l-(ri.l , -biphenyll-4-ylsulfonylVN-[(2RS)-2-hydroxypropyl]-4- (methoxyiminoV2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-sulfonyl chloride, and (2RS)-l-amino-2-propanol, the title compound was obtained in 75 % purity by HPLC. MS(ΕSI+): m/z = 432. Example 306: (2S,4EZ)-l-([l.l'-biphenyll-4-ylsulfonyl)-N-r(2RS)-2-hvdroχy-2-(2- naphthyl ethyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl]-4-sulfonyl chloride, and (lRS)-2-amino-l-(2-naphthyl)ethanol, the title compound was obtained in 77 % purity by HPLC. MS(ΕSI+): m/z = 544. Example 307: (2S,4EZ)-l-(ri,l'-biphenyll-4-ylcarbonyl)-N-rf2RS)-2-hvdroxy-2-(4- nitrophenyl)ethyl]-4-(methoxyimino -2-ρyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (lRS)-2-amino-l-(4-nitrophenyl)ethanol, the title compound was obtained in 84 % purity by HPLC. MS(ΕSI+): m/z = 503. Example 308: (2S,4EZ)-N-r(2RS)-2-hvdroxy-2-(4-nitrophenyl)ethyll-4-(methoxyimino -l-[4- (4-pyridinvI benzoyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidineca boxylic acid, 4-(4-pyridinyl)benzoic acid, and (lRS)-2-amino-l-(4-nifrophenyl)efhanol, the title compound was obtained in 89 % purity by HPLC. MS(ΕSI+): m/z = 504. Example 309: (2S,4EZ)-N-[(2RS)-2-hvdroxy-2-(4-nitrophenyDethyll-4-(methoxyimino -l-r4- (3 -pyridinvDbenzoyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (lRS)-2-amino-l-(4-nitrophenyl)ethanol, the title compound was obtained in 72 % purity by HPLC. MS(ΕSI+): m/z = 504. Example 310: (2S.4EZ)-N-[(2RS)-2-hvdroxy-2-(4-nitroρhenvnethvn-4-(methoxyimino -l 4- (2-pyridinyl benzoyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 4-(2-pyridinyl)benzoic acid, and (lRS)-2-amino-l-(4-nitrophenyl)ethanol, the title compound was obtained in 63 % purity by HPLC. MS(ΕSI+): m/z = 504. Example 311: (2SAEZ)-1 -([1,1 '-biphenyll-4-ylsulfonvn-N-r(2RS -2-hydroxy-2-f 4- nitrophenyl ethyl]-4-(methoxyimino -2-ρyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,1 '-biphenyl] -4-sulfonyl chloride, and (lRS)-2-amino-l-(4-nitrophenyl)ethanol, the title compound was obtained in 79 % purity by HPLC. MS(ΕSI+): m/z = 539. Example 312: (2S,4EZ)-N-{(2RS)-3-r4-( " acetylamino phenoχy]-2-hvdroxypropyl>-l-rr l'- biphenyl]-4-ylcarbonyl -4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and N-(4-{[(2RS)-3-amino-2-hydroxypropyl]oxy}phenyl)acetamide, the title compound was obtained in 79 % purity by HPLC. MS(ΕSI+): m/z = 545. Example 313: (2SAEZ)-N- t(2RS)-3-[4-( acetylamino phenoxy]-2-hvdroxypropyπ -4- (mefhoxyimino)- 1 -[4-(4-pyridinyl)benzoyl]-2-p yrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(4-ρyridinyl)benzoic acid, and N-(4-{[(2RS)-3-amino-2-hydroxypropyl]oxy} phenyl) acetamide, the title compound was obtained in 62 % purity by HPLC. MS(ΕSI+): m/z = 546. Example 314: (2S,4EZ)-N-{(2RS)-3-[4-(acetylamino)phenoχyl-2-hvdroxypropyll-4- (methoxyimino)- 1 - [4-(3 -p yridinvDbenzoyl] -2-pyreolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and N-(4-{[(2RS)-3-amino-2-hydroxypropyl]oxy} phenyl) acetamide, the title compound was obtained in 66 % purity by HPLC. MS(ΕSI+): m/z = 546. Example 315: (2SAEZ)-N- {(2RS)-3-r4-(acetylamino)phenoxy]-2-hvdroxypropyU -1 -( 1,1'- biphenyl]-4-ylsulfonyl -4-(methoxyiminoV2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [l,l'-biphenyl]-4-sulfonyl chloride, and N-(4- {[(2RS)-3-amino-2-hydroxypropyl]oxy} phenyl) acetamide, the title compound was obtained in 62 % purity by HPLC. MS(ΕSI+): m/z = 581. Example 316: (2SAEZ)- ϊlΛ '-biρhenyll-4-ylcarbonyl)-N-[(2R)-2-hvdroxy-2-phenylethvn-4- fmethoχyimino)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22,-starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [l,l'-biphenyl]-4-carbonyl chloride, and (lR)-2-amino-l -phenylethanol, the title compound was obtained in 84 % purity by HPLC. MS(ESI+): m/z = 458. Example 317: (2S.4EZ)-N-[C2RV2-hydroxy-2-phenylethyll-4-(methoxyimino)-l-r4-(4- pyridinyl)benzoyl]-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(4-pyridinyl)benzoic acid, and (lR)-2-amino-l -phenylethanol, the title compound was obtained in 66 % purity by HPLC. MS(ΕSI+): m/z = 459. Example 318: (2S.4EZ)-N-r(2R -2-hydroxy-2-phenylethyll-4-(methoxyimino -l-r4-(3- pyridinyl benzoyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)~l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (lR)-2-amino-l-phenylethanol, the title compound was obtained in 76 % purity by HPLC. MS(ΕSI+): m/z = 459. Example 319: (2S,4EZ)-N-r(2R -2-hydroxy-2-phenylethyl1-4-(methoxyimino -l -[4-(2- pyridinyl benzoyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(2-pyridinyl)benzoic acid, and (lR)-2-amino-l-phenylethanol, the title compound was obtained in 65 % purity by HPLC. MS(ΕSI+): m/z = 459. Example 320: (2S,4EZ)-l-(ri,r-biphenyll-4-ylsulfonyl -N-r(2R -2-hydroxy-2-phenylethvn-4- (methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [l,l'-biphenyl]-4-sulfonyl chloride, and (lR)-2-amino-l -phenylethanol, the title compound was obtained in 87 % purity by HPLC. MS(ΕSI+): m/z = 494. Example 321 : (2S,4EZ -l-(ri,r-biphenyl]-4-ylcarbonyl -N-( ' 3-hvdroxypropyn-4- (methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and 3-amino-l-propanol, the title compound was obtained in 81 % purity by HPLC. MS(ΕSI+): m/z = 395. Example 322: (2SAEZ)-1 -([1,1 '-biphenyl1-4-ylsulfonviyN-(3-hydroxypropylV4- (methoxyimino -2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and 3-amino-l-propanol, the title compound was obtained in 64 % purity by HPLC. MS(ΕSI+): m/z = 432. Example 323 : (3EZ.5S)- 1 -( 1.1 '-biphenyll-4-ylcarbonyl)-5-[(4-hvdroxy-4-ρhenyl- 1 - piperidinyl)carbonyll-3-pyrrolidinone O-mefhyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,l'-biphenyl]-4-carbonyl chloride, and 4-phenyl-4-piperidinol, the title compound was obtained in 74 % purity by HPLC. MS(ΕSI+): m/z = 498. Example 324: (3EZ,5S)-5-[(4-hvdroχy-4-phenyl-l-piρeridinyl)carbonvn-l-[4-(4- pyridinyl)benzoyl]-3-pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(4-pyridinyl)benzoic acid, and 4-phenyl-4-piperidinol, the title compound was obtained in 78 % purity by HPLC. MS(ΕSH-): m/z = 499. Example 325 : (3EZ,5S>5-r(4-hvdroxy-4-ρhenyl-l -piperidinyr)carbonyl]-l -r4-(3- pyridinyDbenzo yll -3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and 4-phenyl-4-piperidinol, the title compound was obtained in 79 % purity by HPLC. MS(ΕSI+): m/z = 499. Example 326: (3EZ,5S)-l-([l.r-biphenyl1-4-ylsulfonyl -5-r(4-hvdroxy-4-phenyl-l- piperidinyl carbonyl]-3-pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,l'-biphenyl] -4-sulfonyl chloride, and 4-phenyl-4-ρiperidinol, the title compound was obtained in 84 % purity by HPLC. MS(ΕSI+): m/z = 534. Example 327: (2SAEZ)-U\1 ,l , -biphenyl]-4-ylcarbonylVN-r(lS,2S -2-hydroxycyclohexyll-4- (methoxyimino)-2-ρynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and (lS,2S)-2-aminocyclohexanol, the title compound was obtained in 84 % purity by HPLC. MS(ΕSI+): m/z = 436. Example 328: (2S,4EZ)-l-( l,r-biphenyl1-4-ylsulfonyl -N-[(lS,2S)-2-hydroχycvclohexyn-4- (methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [l,l'-biphenyl]-4-sulfonyl chloride, and (lS,2S)-2-aminocyclohexanol, the title compound was obtained in 61 % purity by HPLC. MS(ESI+): m/z = 472. Example 329: f2S,4EZ)-N-benzyl-l -([1, r-biphenyl]-4-ylcarbonylVN-(2-hvdroxyethyl -4- (methoxyimino)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyfj-4-carbonyl chloride, and 2-(benzylamino)efhanol, the title compound was obtained in 74% purity by HPLC. MS(ΕSI+): m/z = 472. Example 330: (2S,4EZ)-N-benzyl-N-(2-hvdroxyethylV4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pynolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and 2-(benzylamino)ethanol, the title compound was obtained in 82 % purity by HPLC. MS(ΕSI+): m/z = 473. Example 331 : (3EZ,5S)-l-(ri,l'-biphenyll-4-ylcarbonyl)-5-{[(3RS)-3- hvdroxypiperidinyl]carbonyl) -3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and (3RS)-3-piperidinol, the title compound was obtained in 78 % purity by HPLC. MS(ΕSI+): m/z = 422. Example 332: (3EZ.5S)-5-{r(3RS)-3-hvdroxypiperidinyl1carbonyl>-l-r4-(4- pyridmyl)benzoyl]-3-pyπOlidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 4-(4-pyridinyl)benzoic acid, and (3RS)-3-piperidinol, the title compound was obtained in 91 % purity by HPLC. MS(ΕSI+): m/z = 423. Example 333: (3EZ,5y)-5-{r(3RS)-3-hvdroxypiperidinyllcarbonvn-l-r4-( ' 3- pyridinvDbenzo yl] -3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (3RS)-3-piperidinol, the title compound was obtained in 84 % purity by HPLC. MS(ΕSI+): m/z = 423. Example 334: (3EZ,5S)-l-([l.r-biphenyl1-4-ylsulfonyl -5-{[(3RS)-3- hvdroxypiperidinyl]carbonyl} -3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-sulfonyl chloride, and (3RS)-3-piperidinol, the title compound was obtained in 79 % purity by HPLC. MS(ΕSI+): m/z = 458. Example 335: (2S.4EZ)-l-(ri,l'-biphenyll-4-ylcarbonylVN-r(lS.2S)-2-hydroxy-l- (hydroxymethyl -2-phenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,1 '-biphenyl]-4-carbonyl chloride, and (lS,2S)-2-amino-l-phenyl-l,3-propanediol, the title compound was obtained in 88 % purity by HPLC. MS(ΕSI+): m/z = 488. Example 336: (2S.4EZ)-N-r(lS.2S)-2-hvdroxy-l-(hvdroxymethyl -2-phenylethvn-4- (methoxyimino)-l-[4-(4-pyridinyl)benzoyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(4-ρyridinyl)benzoic acid, and (lS,2S)-2-amino-l-phenyl-l,3-propanediol, the title compound was obtained in 64 % purity by HPLC. MS(ΕSI+): m/z = 489. Example 337: r2S,4EZ)-N-r(lS,2S)-2-hvdroxy-l-αιvdroχymethylV2-phenylethyll-4- (methoxyiminoVl-r4-(3-pyridinyl)benzoyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-ρynolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (lS,2S)-2-amino-l-phenyl-l,3-propanediol, the title compound was obtained in 93 % purity by HPLC. MS(ΕSI+): m/z = 489. Example 338: (2SAEZ)- 1 -(T 1 , 1 '-biphenyl -ylsulfonvn-N-lϊ 1 S.2S)-2-hydroxy-l - (hydroxymethyl -2-phenylethyl1-4-rmethoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-sulfonyl chloride, and (lS,2S)-2-amino-l-phenyl-l,3-propanediol, the title compound was obtained in 82 % purity by HPLC. MS(ΕSI+): m/z = 524. Example 339: (2S,4EZ)-N-r2-anilinoethylVl-rri.l'-biphenyl]-4-ylcarbonvn-4- (methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and N 1 -phenyl- 1 ,2-ethanediamine, the title compound was obtained in 93 % purity by HPLC. MS(ESI+): m/z = 457. Example 340: (2S,4EZ)-N-(2-anilinoethylV4-(methoχyimino -l -[4-(4-pyridinyl benzoyl]-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(4-pyridinyl)benzoic acid, and N 1 -phenyl- 1,2 -ethanediamine, the title compound was obtained in 85 % purity by HPLC. MS(ΕSI+): m/z = 458. Example 341 : ( ' 2S,4EZ)-N-(2-anilinoethyl)-4-toethoxyimino)-l-r4-(3-pyridinyl)benzoyll-2- pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pynolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and N 1 -phenyl- 1,2-ethanediamine, the title compound was obtained in 85 % purity by HPLC. MS(ΕSI+): m/z = 458. Example 342: (2S.4EZ)-N-(2-anilinoethyl -4-(methoχyimino -l-[4-( ' 2-ρyridinvnbenzoyll-2- pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(2-pyridinyl)benzoic acid, and N 1 -phenyl- 1,2-ethanediamine, the title compound was obtained in 67 % purity by HPLC. MS(ΕSI+): m/z = 458. Example 343: (2S,4EZ -N-(2-anilinoethylVl-(ri.r-biphenyll-4-ylsulfonylV4- (methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and N 1 -phenyl- 1,2-ethanediamine, the title compound was obtained in 73 % purity by HPLC. MS(ΕSI+): m/z = 493. Example 344: (3EZ,5S -l-(ri.l'-biphenvn-4-ylcarbonylV5-r(4-hvdroxy-l- piρeridinyl)carbonyl]-3-pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-ρyrrolidinecarboxylic acid, [l,l'-biphenyl]-4-carbonyl chloride, and 4-piperidinol, the title compound was obtained in 86 % purity by HPLC. MS(ESI+): m/z = 422. Example 345: (3EZ,5S)-l-(ri.r-biphenyl]-4-ylsulfonyl)-5-[(4-hvdroχy-l- piperidinyl carbonyl]-3-pynolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,l'-biρhenyl]-4-sulfonyl chloride, and 4-piperidinol, the title compound was obtained in 68 % purity by HPLC. MS(ΕSI+): m/z = 458. Example 346: (2S,4EZ)-N-r(lS,2R,3S,4R -3-(aminocarbonvnbicvclo[2.2.11hept-5-en-2-yll-l- ([l,r-biphenyl]-4-ylsulfonyl -4-(methoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and (lR,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide, the title compound was obtained in 79 % purity by HPLC. MS(ΕSI+): m/z = 509. Examρle 347: ( , 2S,4EZ)-N-(3-amino-3-oxopropylVl-([l,r-biρhenvn-4-ylcarbonylV4- (methoxyimino -2-ρyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and 3-aminoproρanamide, the title compound was obtained in 71 % purity by HPLC. MS(ΕSI+): m/z = 409. Example 348: ( ' 2S.4EZ)-N-[(lS,2S,3R,4RV3-(aminocarbonyl bicvclor2.2.11hept-5-en-2-yll-l- ([l,r-biphenyl]-4-ylsulfonyl)-4-(methoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and (lR,2R,3S,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide, the title compound was obtained in 83 % purity by HPLC. MS(ΕSI+): m/z = 509. Example 349: (2S.4EZ -l-(ri,r-biρhenyl]-4-ylcarbonyl)-N-( " 4-hvdroxybutylV4- (methoxyiminoV2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and 4-amino-l-butanol, the title compound was obtained in 68 % purity by HPLC. MS(ΕSI+): m/z = 410. Example 350: (2S.4EZ)-l-rri,r-biphenyll-4-ylsulfonyl)-N-(4-hvdroxybutylV4- (methoχyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and 4-amino-l-butanol, the title compound was obtained in 78 % purity by HPLC. MS(ΕSI+): m/z = 446. Example 351 : (2S,4EZ)-l-(ri,l'-biphenvn-4-ylsulfonyl)-N-r(lR,2R)-2- (hydroxymethyl cyclohexyl]-4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-sulfonyl chloride, and [(lR,2R)-2-aminocyclohexyl]methanol, the title compound was obtained in 40 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 352: (2S,4EZ)-l-([l,l'-biphenyll-4-ylsulfonylVN-[(lR,2S.3R.4S)-3- (hvdroxymethyl bicyclo[2.2.1]hept-2-yl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [l,l'-biphenyl]-4-sulfonyl chloride, and [(lS,2R,3S,4R)-3-aminobicyclo[2.2.1]hept-2-yl]methanol, the title compound was obtained in 58 % purity by HPLC. MS(ΕSI+): m/z = 498. Example 353: (2S,4EZ)-l- i,l'-biphenyl]-4-ylsulfonylVN-[(lR,2S)-2- (hvdroxymethyl)cvclohexyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-sulfonyl chloride, and [(lS,2R)-2-aminocyclohexyl]methanol, the title compound was obtained in 41 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 354: (2S,4E and 4Z)-N-r(2RS)-2-hydroxy-2-phenylethyll-4-(methoxyimino)-l-r(2'- methyl[ 1 , 1 '-biphenyl] -4-yl carbonyl] -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[ 1 , 1 '-biphenyl]-4- carboxylic acid, and (lRS)-2-amino-l -phenylethanol, the title compounds were obtained as a mixture of Ε/Z-isomers ofthe oxime functionality. Separation ofthe isomers by flash chromatography yielded (2S,4E)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l- [(2'-methyl[l,r-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide in 98.9 % purity and (2S,4Z)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2'-mefhyl[l,r-biphenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide in 99.9% purity by HPLC. MS(ESI+): m/z = 472. Example 355: (2S,4E and 4Z)-N-r(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-r(2'- mefhyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[ 1 , 1 '-biphenyl]-4- carboxylic acid, and (lS)-2-amino-l -phenylethanol, the title compounds were obtained as a mixture of Ε/Z-isomers ofthe oxime functionality. Separation ofthe isomers by flash chromatography yielded (2S,4E)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)- 1 -[(2'- methyl[ 1 , 1 '-biphenyl]-4-yl)carbonyl]-2-ρynolidinecarboxamide in 98.9 % purity and (2S,4Z)- N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(mefhoxyimino)-l-[(2'-mefhyl[l,r-biρhenyl]-4- yl)carbonyl]-2-pynolidinecarboxamide in 99.8 % purity by HPLC. MS(ΕSI+): m/z = 472. Example 356: (2S.4E and 4Z)-N-r(2RV2-hydroxy-2-phenylethvn-4-(methoxyimino -l-r(2'- methyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and (lR)-2-amino-l -phenylethanol, the title compounds were obtained as a mixture of Ε/Z-isomers ofthe oxime functionality. Separation ofthe isomers by flash chromatography yielded (2S,4E)-N-[(2R)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2'- methyl[ 1,1 '-biphenyl] -4-yl)carbonyl]-2-pynolidinecarboxamide in 99.7 % purity and (2S,4Z)- N-[(2R)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)- 1 -[(2'-methyl[ 1 , 1 '-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide in 99.7 % purity by HPLC. MS(ΕSI+): m/z = 472. Example 357: (2S,4EZ)-l-f[l.r-biphenvn-4-ylcarbonyl)-N-r(lR,2S)-2- (hvdroχymethyl)cyclohexyl]-4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and [(lS,2R)-2-aminocyclohexyl]methanol, the title compound was obtained in 63 % purity by HPLC. MS(ESI+): m/z = 450. Example 358: (2S.4EZ)-l-(f 1.1 '-biphenyl] -4-ylcarbonyl -N-[2-hvdroxy-l- (hvdroxymethyl)ethyl1-4-(methoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and 2-amino-l,3-propanedioL the title compound was obtained in 61% purity by HPLC. MS(ΕSI+): m/z = 412. Example 359: (2S.4EZ)-N-r(lS.2R.3S,4RV3-(aminocarbonvnbicyclor2.2.11hept-5-en-2-yll-l- ([1,1 '-biphenyl] -4-ylcarbonylV4-( ' methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (lR,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide, the title compound was obtained in 68 % purity by HPLC. MS(ΕSI+): m/z = 473. Example 360: (2S,4EZ)-N-rflS.2S,3R,4RV3-(aminocarbonvnbicvclor2.2.11hept-5-en-2-yl]-l- ([1,1 '-biphenyl1-4-ylcarbonyl)-4-(meτhoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and (lR,2R,3S,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide, the title compound was obtained in 78 % purity by HPLC. MS(ΕSI+): m/z = 473. Example 361: (2S,4EZ)-l-(ri,r-biphenyll-4-ylcarbonylVN-[( ' 2S)-2-hvdroχy-2-phenylethyll-4- (methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (lS)-2-amino-l -phenylethanol, the title compound was obtained in 87 % purity by HPLC. MS(ESI+): m/z = 458. Example 362: (2RS -3-({[(2S.4EZ)-l-(ri,r-biphenyll-4-ylcarbonyl)-4- (methoxyimino pynolidinyl]carbonyl> amino -2-hvdroxypropanoic acid Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1 ,l'-biphenyl]-4-carbonyl chloride, and (2RS)-3-amino-2-hydroxypropanoic acid, the title compound was obtained in 44 % purity by HPLC. MS(ΕSI+): m/z = 426. Example 363: (2S.4EZ)-N-rriR.2S)-2-raminocarbonyl cvclohexyn-l-( ' [l.r-biρhenyl]-4- ylcarbonyl -4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and (lS,2R)-2-aminocyclohexanecarboxamide, the title compound was obtained in 89 % purity by HPLC. MS(ΕSI+): m/z = 463. Example 364: (2S.4EZ)-l-(ri.r-biρhenyll-4-ylcarbonylVN-[(lRS)-2-hydroxy-l-methylethyll- 4-(methoxyiminoV2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l~(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (2RS)-2-amino-l-propanol, the title compound was obtained in 81 % purity by HPLC. MS(ΕSI+): m/z = 396. Example 365 : (2SAEZ)- !-([ 1 , 1 , -biphenyll-4-ylcarbonvD-N-r(lS,2S)-2-hvdroxy- 1 - (hvdroxymethyl -2-(4-nitrophenyl)ethyl]-4-(methoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and (lS,2S)-2-amino-l-(4-nitrophenyl)-l,3-propanediol, the title compound was obtained in 70 % purity by HPLC. MS(ESI+): m/z = 533. Example 366: 4-(ξ [(2S.4EZ)-l-( , [l.l'-biphenvn-4-ylcarbonyl)-4- (methoxyimino)p yrrolidinyl]carbonyl} amino)butanoic acid Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-ρyrrolidinecarboxylic acid, [1,1 '-biphenyl]-4-carbonyl chloride, and 4-aminobutanoic acid, the title compound was obtained in 57 % purity by HPLC. MS(ΕSI+): m/z = 424. Example 367 : (2S.4EZ)-N-r(2S)-2-hvdroxy-2-phenylethyl] - 1 -[(2'-methoχy[ 1 , 1 '-biphenyl1-4- yl carbonyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methoxy[ 1 , 1 '-biphenyl]- 4-carboxylic acid, and (lS)-2-amino-l -phenylethanol, the title compound was obtained in 90 % purity by HPLC. MS(ΕSI+): m/z = 488. Example 368: (2S.4EZ)-N-[(2RS)-2-hvdroxy-2-(2-naphthvnethyll-l-[( ' 2'-methoxyri.r- biphenyl] -4-yl)carbonyl] -4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methoxy[l,l'-biphenyl]- 4-carboxylic acid, and (lRS)-2-amino-l-(2-naphthyl)ethanol, the title compound was obtained in 67 % purity by HPLC. MS(ΕSI+): m/z = 538. Example 369: f2S.4EZ)-N-r(lRS -2-hvdroxy-l -methylethyl]-4-(methoxyimino -l-r(2'- methyl[l,r-biphenyl]-4-yl carbonyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pynolidinecarboxylic acid, 2'-mefhyl[ 1,1 '-biphenyl] -4- carboxylic acid, and (2RS)-2-amino-l-propanol, the title compound was obtained in 88 % purity by HPLC. MS(ESI+): m/z = 410. Example 370: (2S,4EZ)-N-rαS,2S)-2-hvdroxy-l-(hvdroxymethyl)-2-(4-nitrophenyl)ethyl1-4- (methoxyimino)- 1 - [(2'-methvir 1 , 1 '-biphenyl] -4-yl)carbonyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and (lS,2S)-2-amino-l-(4-nitrophenyl)-l,3-ρropanediol, the title compound was obtained in 74 % purity by HPLC. MS(ΕSI+): m/z = 547. Example 371 : (2S,4EZ)-N-[αS,2S)-2-hvdroxy-l-rhvdroxymethvn-2-( ' 4-nitrophenvnethyll-4- (methoxyimino)- 1 -[f2'-mefhoxy[ 1 , 1 '-biphenyl]-4-yl carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2 '-methoxy [ 1 , 1 '-biphenyl] - 4-carboxylic acid, and (lS,2S)-2-amino-l-(4-nitrophenyl)-l,3-propanediol, the title compound was obtained in 61% purity by HPLC. MS(ΕSI+): m/z = 563. Example 372: (3EZ,5S -5-r( " 4-hvdroxy-l-piperidinvncarbopyll-l-r(2'-methvin.l'-biphenyll-4- yl carbonyl]-3-pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and 4-piperidinol, the title compound was obtained in 86 % purity by HPLC. MS(ΕSI+): m/z = 436. Example 373: (2S.4EZ)-N-r(lS,2S,3R,4R)-3-(aminocarbonyl)bicvclor2.2.1]hept-5-en-2-vn-4- (methoxyimino -l-[(2'-methyl[l, -biphenyl]-4-yl carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and (lR,2R,3S,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide, the title compound was obtained in 55 % purity by HPLC. MS(ESI+): m/z = 487. Example 374: (2S,4EZ -N-r(2RS)-2-hydroxy-2-phenylethvn-l-r(2'-methoxyri.l'-biphenyl]-4- yl)carbonyl]-4-(methoχyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methoxy[l,l'-biphenyl]- 4-carboxylic acid, and (lRS)-2-amino-l -phenylethanol, the title compound was obtained in 82 % purity by HPLC. MS(ΕSI+): m/z = 488. Example 375: (2S,4EZ)-N-[(2RS)-2-hvdroxypropyll-4-(methoxyimino -l-r(2'-methviri.r- biphenyl1-4-yl)carbonyl1-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and (2RS)-l-amino-2-propanol, the title compound was obtained in 90 % purity by HPLC. MS(ΕSI+): m/z = 410. Example 376: S.4EZ>-N-rr2RS)-2.3-dihvdroxypropyll-4-(methoxyiminoVl-r('2 , -methviri,l'- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and (2RS)-3-amino-l, 2-propanediol, the title compound was obtained in 67 % purity by HPLC. MS(ΕSI+): m/z = 426. Example 377: (2S,4EZ)-N-(3-hvdroxypropyl)-4-tmethoxyimino)- 1 -r(2'-methvir 1 , 1 '-biphenyll- 4- yl)carbonvn-2-pyrroli dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[l,l '-biphenyl] -4- carboxylic acid, and 3-amino-l-propanol, the title compound was obtained in 90 % purity by HPLC. MS(ESI+): m z = 410. Example 378 : (2S.4EZ)-N-(2-amino-2-oxoethyl)- 1 -([1,1 '-biρhenvn-4-ylcarbonyl)-4- (methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and 2-aminoacetamide, the title compound was obtained in 82 % purity by HPLC. MS(ΕSI+): m/z = 395. Example 379: (2S.4EZ)-N-( " 2-amino-2-oxoethyl -4-(methoxyimino)-l -IT2'-methvir 1.1'- biphenyl]-4-yl carbonyl]-2-pyrcolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[ 1 , 1 '-biphenyl] -4- carboxylic acid, and 2-aminoacetamide, the title compound was obtained in 92 % purity by HPLC. MS(ΕSI+): m/z = 409. Example 380: (2S,4EZ)-l-([l,l'-biphenyl1-4-ylcarbonvD-N-r(2RS)-2-hvdroxy-2-(3- hvdroxyphenyl ethyl]-4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1 ,1 '-biphenyl] -4-carbonyl chloride, and 3-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 88 % purity by HPLC. MS(ΕSI+): m/z = 504. Example 381 : (2S,4EZ)-l-(ri,r-biphenyl]-4-ylcarbonyl)-N-rT lS,2R.3S.4R)-3- (hydroxymethvDbicyclo [2.2.11hept-2-yl] -4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and [(lR,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-2-yl]methanol, the title compound was obtained in 64 % purity by HPLC. MS(ESI+): m/z = 462. Example 382: (2S,4EZ)-N-r(lR,2S,3R,4S)-3-(hvdroxymethyl bicvclor2.2.11hept-2-yl]-l-[(2'- methoxy[l,r-biphenyl]-4-yl carbonyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methoxy[ 1 , 1 '-biphenyl]- 4-carboxylic acid, and [(lS,2R,3S,4R)-3-aminobicyclo[2.2.1]hept-2-yl]mefhanol, the title compound was obtained in 56 % purity by HPLC. MS(ΕSI+): m/z = 492. Example 383: (2S.4EZ)-N-(tran,??-4-hvdroxyc yclohex ylV 1 -rø'-mefhoxyr 1.1 '-biphenyl - yl carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 '-methoxy[ 1 , 1 '-biphenyl] - 4-carboxylic acid, and trøns-4-aminocyclohexanol, the title compound was obtained in 61 % purity by HPLC. MS(ΕSI+): m/z = 466. Example 384: (2S,4EZ)-N-[(lR.2RV2-(hydroxymethyl)cyclohexyl]-l-[(2'-methoxyπ.l'- biphenyl]-4-yl)carbonyl]-4-(methoχyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methoxy[ 1 , 1 '-biphenyl]- 4-carboxylic acid, and [(lR,2R)-2-aminocyclohexyl]methanol, the title compound was obtained in 68 % purity by HPLC. MS(ΕSI+): m/z = 480. Example 385: (2S.4EZ)-N-r(2RS)-2-hydroxy-3-phenoχypropyn-4-(methoχyimino)-l-[(2'- methylfl, -biphenyll-4-yl)carbonyl1-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[ 1 , 1 '-biphenyl]-4- carboxylic acid, and (2RS)-l-amino-3-phenoxy-2-propanol, the title compound was obtained in 80 % purity by HPLC. MS(ESI+): m/z = 502. Example 386: (2S,4EZ -N-r(2RS)-2-hvdroxy-2-r4-hvdroxyphenyl)ethvn-4-(methoxyimino -l- [(2'-methyl[ 1 , 1 '-biphenyl] -4- vDcarbonyij -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and 4-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 76 % purity by HPLC. MS(ΕSI+): m/z = 488. Example 387: (2S,4EZ)-N-r(2RS)-2-hvdroxy-2-(4-hvdroxyphenyl)ethyll-4-(methoxyimino)-l- [(2'-methoxy[l,r-biphenyl1-4-yl carbonyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methoxy[l,l'-biphenyl]- 4-carboxylic acid, and 4-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 90 % purity by HPLC. MS(ΕSI+): m/z = 504. Example 388: (2S,4EZ)-N-r(2RS)-2-hvdroxy-2-r4-hvdroxy-3-mefhoxyρhenvnethyl1-l-r(2'- methyl[l, -biphenyl]-4-yl)carbonyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-mefhyl[l,l'-biphenyl]-4- carboxylic acid, and 4-[(lRS)-2-amino-l-hydroxyethyl]-2-methoxyphenol, the title compound was obtained in 67 % purity by HPLC. MS(ΕSI+): m/z = 518. Example 389: (2S,4EZ)-N-r(2RS)-2-hvdroxy-2-(4-hvdroxy-3-methoxyphenvnethyll-l-r(2'- methoxy [ 1 , 1 '-biphenyl] -4-yl)carbonyl] -4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methoxy[ 1 , 1 '-biphenyl]- 4-carboxylic acid, and 4-[(lRS)-2-amino-l-hydroxyethyl]-2-methoxyphenol, the title compound was obtained in 87 % purity by HPLC. MS(ESI+): m/z = 534. Example 390: (2S,4EZ)-N-[(2RS)-2-(3,4-dihydroxyphenyl)-2-hvdroχyethyll-l -\( - methoxy [ 1 , 1 '-biphenyl] -4-yl carbonyl] -4-(methoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methoxy[ 1 , 1 '-biphenyl]- 4-carboxylic acid, and 4-[(lRS)-2-amino-l-hydroxyethyl]-l,2-benzenediol, the title compound was obtained in 69 % purity by HPLC. MS(ΕSI+): m/z = 520. Example 391 : (2R.4EZ)-l-(Tl,l'-biphenyn-4-ylcarbonyl)-N-r(2RS)-2-hvdroxy-2-ρhenylethvn- 4-(methoχyimino)-2-ρyrroli dinecarboxamide Following the general method as outlined in Example 22, starting from (2R,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (lRS)-2-amino-l-phenylethanol, the title compound was obtained in 90 % purity by HPLC. MS(ΕSI+): m/z = 456. Example 392: (2R.4EZ)-N-r(2RS)-2-hvdroxy-2-ρhenylethyl]-4-(methoxyimino -l-r(2'- methyl[ 1 , 1 '-biphenyl] -4-yl carbonyl] -2- yrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2R,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[ 1 , 1 '-biphenyl]-4- carboxylic acid, and (lRS)-2-amino-l-phenylethanol, the title compound was obtained in 94 % purity by HPLC. MS(ΕSI+): m/z = 472. Example 393 : (2SAEZ)-1 -[(2'-cvanor 1.1 '-biphenyl1-4-vncarbonyl]-N-r(2RSy2-hvdroχy-2- phenylethyl]-4-(methoχyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-cyano[l,l'-biphenyl]-4- carboxylic acid, and (lRS)-2-amino-l -phenylethanol, the title compound was obtained in 86 % purity by HPLC. MS(ESI+): m/z = 483. Example 394: (2S,4EZ)-l-[(3'.4'-dichloro[l.r-biphenyl]-4-yl carbonyl]-N-[(2RS -2-hydroxy- 2-phenylethyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 3 ' ,4 ' -dichloro [1,1 - biphenyl]-4-carboxylic acid, and (lRS)-2-amino-l -phenylethanol, the title compound was obtained in 89 % purity by HPLC. MS(ΕSI+): m/z = 527. Example 395: (2S.4EZ)-l-[(2'.6'-dimethviri,l'-biphenyl]-4-vncarbonyl1-N-r(2RS)-2-hvdroxy- 2-phenylethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxy imino)-2-pynolidinecarboxylic acid, 2 ' ,6 ' -dimethyl[ 1 , 1 '- biphenyl]-4-carboxylic acid, and (lRS)-2-amino-l -phenylethanol, the title compound was obtained in 95 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 396: (2S.4EZ)-l-[(2',3-dimethviri,r-biphenyll-4-vncarbonyll-N-r(2RS)-2-hydroχy- 2-ρhenylethyl1-4-(methoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2',3-dimethyl[l , 1 '- biphenyl]-4-carboxylic acid, and (lRS)-2-amino-l -phenylethanol, the title compound was obtained in 83 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 397: (2S.4EZ)-N-r(2RS)-2-hydroxy-2-(3-hydroxyphenyl ethyl1-4-(methoχyimino)-l- [(2'-methyl[ 1 , 1 '-biphenyl]-4-yl carbonyl]-2-pyreolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and 3-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 70 % purity by HPLC. MS(ESI+): m/z = 488. Example 398: (2S,4EZ)-N-[(2RS)-2-hvdroχy-2-(3-hvdroxyρhenyl ethyll-4-fmethoxyimino)-l- [(2'-cyano [1,1 '-biphenyl] -4-yl)carbonyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbony l)-4-(mefhoxy imino)-2-pynolidinecarboxylic acid, 2 ' -cyano [1,1 '-biphenyl]-4- carboxylic acid, and 3-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 86 % purity by HPLC. MS(ΕSI+): m/z = 499. Example 399: (2S.4EZ)-N-[(2RS)-2-hydroxy-2-(3-hvdroxyphenynethyll-4-(methoxyiminoVl- [(3'.4'-dichlorori.r-biphenyl1-4-yl carbonyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 3 ' ,4 ' -dichlorof 1 , 1 '- biphenyl] -4-carboxylic acid, and 3-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 91 % purity by HPLC. MS(ΕSI+): m/z = 543. Example 400: (2S.4EZ)-N-r(2RS)-2-hvdroxy-2-( ' 3-hydroxyphenynethyll-4-(methoχyimino)-l- [(2'.6 ' -dimethyl r 1 , 1 '-biphenyl] -4-yl carbonyl] -2-pyreolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' ,6 ' -dimethyl[ 1 , 1 '- biphenyl]-4-carboxylic acid, and 3-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 87 % purity by HPLC. MS(ΕSI+): m/z = 502. Example 401 : (2S.4EZ)-N-r(2RS)-2-hvdroxy-2-(3-hvdroxyphenyl)ethyll-4-(methoxyimino)-l- [(2',3-dimethyl[l , 1 '-biphenvn-4-yl)carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(mefhoxyimino)-2-pyrrolidinecarboxylic acid, 2',3-dimethyl[l,l'- biphenyl] -4-carboxylic acid, and 3-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 91 % purity by HPLC. MS(ESI+): m/z = 502. Example 402: r2S.4EZ)-l-r(3'.4'-dichlorori.l'-biphenyll-4-yl carbonyl]-N-r(2RS)-2-hvdroχy- 2-(4-hvdroxyphenyl ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 3 ' ,4 ' -dichloro [1,1'- biphenyl] -4-carboxylic acid, and 4-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 86 % purity by HPLC. MS(ΕSI+): m/z = 543. Example 403: S^EZl-l-r^'.e'-dimethvir l'-biphenyll^-yncarbonvq-N-r^RSl^-hvdroxy- 2-(4-hvdroxyphenyl)ethyl]-4-(methoxyimino)-2-ρyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxy carbonyl)-4-(methoxy imino)-2-pyrrolidinecarboxylic acid, 2 ' ,6 ' -dimethy 1[ 1 , 1 '- biphenyl] -4-carboxylic acid, and 4-[(lRS)-2-amino-l-hydroxyethyl]phenol, the title compound was obtained in 89 % purity by HPLC. MS(ΕSI+): m/z = 502. Example 404: (2S.4EZ)-l-r(2'.3-dimethviri,l'-biphenyl]-4-vncarbonyll-N-r(2RS)-2-hvdroxy- 2-(4-hydroxyphenyl ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ',3 -dimethyl [1,1'- biphenyl]-4-carboxylic acid, and 4-[(lRS)-2-amino-l-hydroxyethyl]ρhenol, the title compound was obtained in 90 % purity by HPLC. MS(ΕSI+): m/z = 502. Example 405: (2S.4EZ)-l-[(2',6'-dimethyl[l,l'-biphenyl1-4-vncarbonyll-N-[(2RS)-2-hvdroxy- 3-(4-methoxyphenoxy propyn-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2',6'-dimethyl[l,l'- biphenyl]-4-carboxylic acid, and (2RS)-l-amino-3-(4-methoxyphenoxy)-2-propanol, the title compound was obtained in 87 % purity by HPLC. MS(ESI+): m/z = 546. Example 406: (2S,4EZ)-l-[(2',3-dimethyl[l,r-biphenyn-4-yl carbonyn-N-[(2RS -2-hvdroxy- 3-(4-methoxyphenoxy propyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2',3-dimethyl[l,l'- biphenyl] -4-carboxylic acid, and (2RS)-l-amino-3-(4-methoxyphenoxy)-2-propanol, the title compound was obtained in 77 % purity by HPLC. MS(ΕSI+): m/z = 546. Example 407: (2S,4EZ)-N-f2-amino-2-oxoethyl -l -fT2'.6'-dimefhyll ~ l , 1 '-biphenyl]-4- yl)carbonyl]-4-(methoxyimino -2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2',6'-dimethyl[l ,1'- biphenyl] -4-carboxylic acid, and 2-aminoacetamide, the title compound was obtained in 88 % purity by HPLC. MS(ΕSI+): m/z = 423. Example 408: (2S.4EZ)-N-(2-amino-2-oxoethvn-l-r(2',3-dimethviπ.l'-biphenvn-4- yl)carbonyl]-4-(methoxyiminoV2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2' ,3 -dimethyl[ 1 , 1 '- biphenyl]-4-carboxylic acid, and 2-aminoacetamide, the title compound was obtained in 85 % purity by HPLC. MS(ΕSI+): m/z = 423. Example 409: (2S.4EZ)-N-(3-amino-3-oxoproρyl')-l-[(2 , .6'-dimefhyl[l.l'-biρhenyn-4- yl carbonyl]-4-(methoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2 ' ,6 ' -dimethyl [1,1'- biphenyl] -4-carboxylic acid, and 3-aminopropionamide, the title compound was obtained in 87 % purity by HPLC. MS(ESI+): m/z = 437. Example 410: f2S.4EZ)-N-(3-amino-3-oxoρroρvn-l -fT2'.3-dimethyl[l ,1 '-biphenyl] -4- yl)carbonyl]-4-(methoχyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxy imino)-2-pynolidinecarboxylic acid, 2 ' ,3 -dimethyl [ 1 , 1 '- biphenyl]-4-carboxylic acid, and 3-aminopropionamide, the title compound was obtained in 87 % purity by HPLC. MS(ΕSI+): m/z = 437. Example 411: (2SAEZ)- 1 -rø'.ό'-dimethvir 1.1 '-biphenyl]-4-vncarbonyll-N-r2-hvdroxy- 1 - (hvdroxymethyl ethyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxy carbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' ,6 ' -dimethyl [1,1'- biphenyl]-4-carboxylic acid, and 2-amino-l,3-propanediol, the title compound was obtained in 70 % purity by HPLC. MS(ΕSI+): m/z = 440. Example 412: (2S.4EZ -l-r(2',3-dimethviri.r-biphenyl1-4-vncarbonvn-N-r2-hvdroxy-l- (hydroxymethyl)ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbony l)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' ,3 -dimethyl [1,1'- biphenyl]-4-carboxylic acid, and 2-amino-l,3-propanediol, the title compound was obtained in 68 % purity by HPLC. MS(ΕSI+): m/z = 440. Example 413: (2S.4EZV1 -r(2'-cvano[ 1 ,r-biphenyl]-4-yl carbonvn-N-[(lR,2R -2- (hydroχymethyl cyclohexyl]-4-(methoxyimino ' )-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-cyano[l ,1 '-biphenyl] -4- carboxylic acid, and [(lR,2R)-2-aminocyclohexyl]methanol, the title compound was obtained in 78 % purity by HPLC. MS(ESI+): m/z «= 475. Example 414: (3EZ,5S -5-(3,4-dihydro-2(lH)-isoquinolinylcarbonyl)-l-r(2'.3-dimethviri,r- biphenyl]-4-yl carbonyll-3-pynolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2',3-dimethyl[l,r- biphenyl] -4-carboxylic acid, and 1,2,3,4-tetrahydroisoquinoline, the title compound was obtained in 77 % purity by HPLC. MS(ΕSI+): m/z = 482. Example 415: (2S,4EZ)-N-r(lR)-2-hydroxy-l-phenylethyl]-4-(methoχyiminoVl-r(2'- methyl[l,r-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-methyl[l,r-biphenyl]-4- carboxylic acid, and (2R)-2-amino-2-phenylethanol, the title compound was obtained in 91 % purity by HPLC. MS(ΕSI+): m/z = 472. Example 416: (2S,4EZ)-l-rr2'.6'-dimethyl[l.l'-biphenvn-4-vncarbonvn-N-r2-(4- hydroxyphenyl)ethyll-4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2' ,6'-dimethyl[l , 1 '- biphenyl]-4-carboxylic acid, and 4-(2-aminoethyl)phenol, the title compound was obtained in 87 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 417: (2SAEZ)- 1 -r(2'.3-dimefhyl[ 1 , 1 '-biphenvn-4-yl)carbonyl1-N-[2-(4- hvdroxyphenyl)ethyll-4-(methoxyimino)-2-pyrroli dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' ,3 -dimethyl [1,1'- biphenyl]-4-carboxylic acid, and 4-(2-aminoethyl)phenol, the title compound was obtained in 83 % purity by HPLC. MS(ESI+): m/z = 486. Example 418: (2S.4EZ)-l-r(2',6'-dimethyl[l,l , -biphenyll-4-vncarbonyll-N- 2-(3- hvdroxyphenyl ethvn-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' ,6 ' -dimethyl[ 1 , 1'- biphenyl] -4-carboxylic acid, and 3-(2-aminoefhyl)phenol, the title compound was obtained in 81 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 419: (2SAEZ)-l-\(2 3-dimethγll 1.1 '-biphenyl]-4-yl)carbonyl]-N-r2-(3- hydroxyphenyl)ethyl]-4-(methoxyimino -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4E2)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2',3-dimethyl[l,l'- biphenyl] -4-carboxylic acid, and 3-(2-aminoethyl)phenol, the title compound was obtained in 89 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 420: (2S,4EZ -l-[(2',3-dimethyl[l.r-biphenyl]-4-yl carbonyll-N-[(lR.2S)-2- hvdroxy-l,2-diρhenylethyl]-4-(methoxyimino)-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbony l)-4-(mefhoxyimino)-2-pynolidinecarboxylic acid, 2 ' ,3 -dimethyl [1,1'- biphenyl]-4-carboxylic acid, and (lS,2R)-2-amino-l,2-diphenylethanol, the title compound was obtained in 73 % purity by HPLC. MS(ΕSI+): m/z = 562. Example 421: (2RS)-2-r({(2S,4EZ -4-(methoxyimino)-l-[(2'-methyl[l.r-biphenyl]-4- yl carbonyl]pyrrolidinyl} carbonyl amino]-3-phenylpropanoic acid Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' -methyl [1,1 '-biphenyl] -4- carboxylic acid, and DL-phenylalanine, the title compound was obtained in 62 % purity by HPLC. MS(ESI+): m/z = 500. Example 422: (2S,4EZ)-N-r(lR,2S)-2-(aminocarbonyl)cvclohexyn-l-[(2'.6'-dimethyl[l,r- biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-ρyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-1 -(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2',6'-dimethyl[l ,1'- biphenyl] -4-carboxylic acid, and (lS,2R)-2-aminocyclohexanecarboxamide, the title compound was obtained in 92 % purity by HPLC. MS(ΕSI+): m/z = 491. Example 423: r2S.4EZ)-N-rdR,2S)-2-(aminocarbonyl)cvclohexyll-l-[(2',3-dimethviri,r- biphenyl] -4-yl carbonyl] -4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbony l)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2 ' ,3 -dimethyl [1,1'- biphenyl]-4-carboxylic acid, and (lS,2R)-2-aminocyclohexanecarboxamide, the title compound was obtained in 91 % purity by HPLC. MS(ΕSI+): m/z = 491. Example 424: 4'- ([(2S.4EZV2- {r4-(2-hvdroxyethylV 1 -piperazinvflcarbonvU -4- (methoxyimino pyrrolidinyl]carbonyl>[l,r-biphenyl]-2-carbonitrile Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-cyano[l,l'-biphenyl]-4- carboxylic acid, and 2-(l-piperazinyl)ethanol, the title compound was obtained in 89 % purity by HPLC. MS(ΕSI+): m/z = 476. Example 425: (3EZ,5S -l-r '.4'-dichlorori.r-biphenyll-4-yl carbonyl]-5-{[4-(2- hvdroxyethyl -l-piperazinyl]carbonv -3-pynolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 3 ' ,4 '-dichloro [1,1'- biphenyl] -4-carboxylic acid, and 2-(l-piperazinyl)ethanol, the title compound was obtained in 86 % purity by HPLC. MS(ESI+): m/z = 520. Example 426: (3EZ.5SH -[(2',6'-dimefhviri .1 '-biphenvn-4-yl)carbonyll-5-ir4-(2- hydroxyethyiy 1 -piρerazinyl]carbonyl} -3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2',6'-dimethyl[l,l'- biphenyl] -4-carboxylic acid, and 2-(l-ρiperazinyl)ethanol, the title compound was obtained in 79 % purity by HPLC. MS(ΕSI+): m/z = 479. Example 427: (3EZ.5S)-l-r(2',3-dimethyl[l.l'-biphenyll-4-yl)carbonyll-5-(r4-(2- hydroxyethyl)- 1 -piperazinyl] carbonyl} -3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2',3-dimethyl[l,l'- biphenyl]-4-carboxylic acid, and 2-(l-piperazinyl)ethanol, the title compound was obtained in 86 % purity by HPLC. MS(ΕSI+): m/z = 479. Example 428: (3EZ.5SV l-[(2'-methyl[l .l'-biphenvn-4-yl)carbonvn-5-((4-r4- (trifluoromethyl)phenyl]- 1 -piperazinyl) carbonyl)-3-pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' -methyl [1 , 1 '-biphenyl] -4- carboxylic acid, and l-[4-(trifluoromethyl)phenyl]piperazine, the title compound was obtained in 89 % purity by HPLC. MS(ΕSI+): m/z = 565. Example 429: (3EZ.5S -l-f(2'-methyl[l,l'-biphenvn-4-yl carbonyl]-5-( (4-r3- (trifluoromefhyl)phenyl]-l -piperazinyl} carbonyl)-3 -pyrrolidinone O-methyloxime Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' -methyl[ 1 , 1 '-biphenyl] -4- carboxylic acid, and l-[3-(trifluoromethyl)phenyl]piperaκine, the title compound was obtained in 88 % purity by HPLC. MS(ESI+): m/z = 565. Example 430: (2S,4EZ)-4-(methoχyimino)-l-[(2'-methyl[l.r-biρhenyl]-4-vncarbonyl1-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2' -methyl [1,1 '-biphenyl] -4- carboxylic acid, and ammonia (0.5M in dioxane), the title compound was obtained in 88 % purity by HPLC. MS(ΕSI+): m/z = 352. Example 431 : (2S,4EZ)-4-(methoχyimino)-N-methyl-l-r(2'-methviπ,l'-biphenyl1-4- yl carbonyl]-2-ρyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[l,l'-biphenyl]-4- carboxylic acid, and methylamine (2M in methanol), the title compound was obtained in 96 % purity by HPLC. MS(ΕSI+): m/z = 366. Example 432: (2S,4EZ)-4-(methoxyimino -NN-dimethyl-l -fY2'-methvir 1.1 '-biphenyl] -4- yl carbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[l , 1 '-biphenyl]-4- carboxylic acid, and dimethylamine (5.6M in ethanol), the title compound was obtained in 94 % purity by HPLC. MS(ΕSI+): m/z = 380. Example 433 : (2S.4EZ)-N-[(3R)-3-hvdroxy-3-ρhenylρroρyl]-4-(methoxyiminoVl -[(2'- methyl[ 1 , 1 '-biphenyl] -4-yl carbonyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2 ' -methyl [1,1 '-biphenyl] -4- carboxylic acid, and (lR)-3-amino-l-phenyl-l-propanol, the title compound was obtained in 94% purity by HPLC. MS(ESI+): m/z = 486. Example 434: (2S.4EZ)-N-[(3S)-3-hvdroχy-3-ρhenylpropyl]-4-(methoxyimino)-l-[(2'- methyl[l, -biphenyl]-4-yl)carbonyll-2-pyrroli dinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[l ,l'-biphenyl]-4- carboxylic acid, and (lS)-3-amino-l-phenyl-l-propanol, the title compound was obtained in 91 % purity by HPLC. MS(ΕSI+): m/z = 486. Example 435 : (2S.4EZH -f[ 1.1 '-biphepyn-4-ylcarbonyl -N-[(3RV3-hvdroxy-3-phenylpropyl1- 4-(methoxyimmo -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [l,l'-biphenyl]-4-carbonyl chloride, and (lR)-3-amino-l-phenyl-l-propanol, the title compound was obtained in 94 % purity by HPLC. MS(ΕSI+): m/z = 472. Example 436: (2SAEZ)- \1.r-biρhenyll-4-ylcarbonylVN-r(3S -3-hvdroxy-3-phenylpropyn- 4-(methoxyimino)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, [1,1 '-biphenyl] -4-carbonyl chloride, and (lS)-3-amino-l-phenyl-l-propanol, the title compound was obtained in 93 % purity by HPLC. MS(ΕSI+): m/z = 472. Example 437: (2S,4EZ)-N-[(2S)-2-hvdroχy-2-phenylethyll-4-(methoχyimino -l- (r2'- (trifluoromefhyl [l,r-biphenyl]-4-yl]carbonyl}-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-(trifluoromethyl)[l,r- biphenyl]-4-cafboxylic acid, and (lS)-2-amino-l -phenylethanol, the title compound was obtained in 87 % purity by HPLC. MS(ESI+): m/z = 526. Example 438: (2S,4EZ)-N-[(2S)-2-hvdroxy-2-phenylefhyl]-4-(methoxyimino)-l- i\ - chloro[ 1 ,1 '-biphenyl]-4-yl]carbonyl) -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2'-chloro[l,l'-biphenyl]-4- carboxylic acid, and (lS)-2-amino-l -phenylethanol, the title compound was obtained in 89% purity by HPLC. MS(ΕSI+): m/z = 492. Example 439: r2S.4EZ)-N-(2-hvdroχyphenvD-4-( ' methoxyimino)-l-r(2'-methyl[l,r-biρhenvn- 4-yl carbonyl]-2-pynolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[l ,1 '-biphenyl] -4- carboxylic acid, and 2-aminophenol, the title compound was obtained in 88 % purity by HPLC. MS(ΕSI+): m/z = 444. Example 440: (2S,4EZ)-N-[2-αιydroxymethynphenvn-4-fmethoxyimino - 1 -[(2'-methyir 1 , 1 '- biphenyl]-4-vDcarbonyl]-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2'-methyl[ 1,1 '-biphenyl] -4- carboxylic acid, and (2-aminophenyl)methanol, the title compound was obtained in 86% purity by HPLC. MS(ΕSI+): m/z = 458. Example 441 : (2S.4EZ)-N-[(2S -2-hvdroxy-2-phenylethvn-4-(methoxyimino)-l-[(2- methyl[ 1 , 1 '-biphenyl] -4-yl carbonyl] -2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2-mefhyl[ 1 , 1 '-biphenyl] -4- carboxylic acid, and (lS)-2-amino-l-phenylethanol, the title compound was obtained in 95 % purity by HPLC. MS(ESI+): m/z = 472. Example 442: (2S.4E and 4Z^-l-([l.l , -biρhenyl1-4-ylcarbonyl)-N-r(2S)-2-hydroxy-2- phenylethyl]-4-(methoxyimino)-2 -pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1 '-biρhenyfJ-4-carbonyl chloride, and (lS)-2-amino-l-phenylethanol, the title compounds were obtained as a mixture of E/Z-isomers ofthe oxime functionality. Separation ofthe isomers by flash chromatography yielded (2SAE)-1 -([1,1 '-biphenyll-4-ylcarbonyl)-N-r(2S)-2-hvdroxy-2-phenylethyll-4- (methoxyimino)-2 -pyrrolidinecarboxamide in 98.8 % purity and (2SAZ)- 1 -([ 1.1 '-biphenyl]-4- ylcarbonyl)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-2 -pyrrolidinecarboxamide in 97.4 % purity by HPLC. MS(ESI+): m/z = 458. Example 443: (2S.4EZ)-4-(methoxyiminoVl-[(2'-methviri.l'-biphenvn-4-yl carbonyl]-N-(2- phenylethyl)-2-pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pynolidinecarboxylic acid, 2-methyl[ 1 , 1 '-biphenyl]-4- carboxylic acid, and 2-phenylethanamine, the title compound was obtained in 89% purity by .HPLC. MS(ΕSI+): m/z = 456. Example 444: (2S,4EZ)-N-(2-hydroxyethyl)-4-(methoxyimino - 1 -nonanoyl-2- pyrrolidinecarboxamide Following the general method as outlined in Example 22, starting from (2S,4EZ)-l-(tert- butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, nonanoic acid, and 2- aminoethanol, the title compound was obtained in 93% purity by HPLC. MS(ESI+): m/z = 342. Example 445 : Preparation of a pharmaceutical formulation The following formulation examples illustrate representative pharmaceutical compositions of this invention containing pyrrolidine derivatives according to formula I. The present in- vention, however, is not limited to the following pharmaceutical compositions. Formulation 1 - Tablets A compound of formula I is admixed as a dry powder with a dry gelatin binder in an approximate 1:2 weight ration. A minor amount of magnesium stearate is added as a lubricant. The mixture is formed into 240-270 mg tablets (80-90 mg of active pyrrolidine derivatives according to formula I per tablet) in a tablet press. Formulation 2 - Capsules A compound of formula I is admixed as a dry powder with a starch diluent in an approxi-mate 1:1 weight ratio. The mixture is filled into 250 mg capsules (125 mg of active pyrrolidine derivatives according to formula I per capsule). Formulation 3 - Liquid A compound of formula I (1250 mg), sucrose (1.75 g) and xanthan gum (4 mg) are blended, passed through a No. 10 mesh U.S. sieve, and then mixed with a previously made solution of microcrystalline cellulose and sodium carboxymethyl cellulose (11:89, 50 mg) in water. Sodium benzoate (10 mg), flavor, and color are diluted with water and added with stirring. Sufficient water is then added to produce a total volume of 5 mL. Formulation 4 - Tablets The compound of formula I is admixed as a dry powder with a dry gelatin binder in an approximate 1:2 weight ratio. A minor amount of magnesium stearate is added as a lubricant. The mixture is formed into 450-900 mg tablets (150-300 mg of active pyrrolidine derivatives according to formula I) in a tablet press. Formulation 5 - Injection The compound of formula I is dissolved in a buffered sterile saline injectable aqueous medium to a concentration of approximately 5 mg/ml. The compounds ofthe present invention may be subjected to the following biological assays : Example 446 : Biological assays a) Production of Recombinant Bax Human Bax-α lacking 20 amino acids at the COOH-terminus is expressed as a GST fusion protein or a His-tagged protein in Escherichia coli, and the protein is purified from the soluble cell fraction. In brief, the GST-Bax fusion protein is applied to a glutathione-Sepharose column, and Bax was released by cleavage with thrombin (0.6U/mL). Bax is subsequently purified on heparin-Sepharose, followed by fast protein liquid chromatography (FPLC) Mono Q. His-tagged Bax is purified on a Ni-nitriloacetic acid-agarose column followed by FPLC MonoQ: b) Isolation of Mitochondria Mitochondria are isolated from mouse liver cells by differential centrifugation. Cells are broken with a dounce homogenizer and the suspension is centrifuged at 2,000 g in an Eppendorf centrifuge at 4 °C. This procedure is repeated until almost all the cells are broken. Supernatants from each step are pooled before centrifugation at 13,000 g at 4 °C for 10 min. The pellet is resuspended in 40 mL MB buffer and centrifuged at 2000 g for 2 min. The supernatant is removed and centrifuged at 13 kg for 4 min. The mitochondria are recovered in the 13k pellet and resuspended in MB buffer at a density of 30 OD600 nm/mL. c) In Vitro Assay for Cytochrome c Release Mitochondria (30 μg) from mouse liver are incubated with 200 nM recombinant Bax in the presence of various compounds (5 μM) in 200 μL of KC1 buffer for 20 min at 30 °C and are then centrifuged for 4 min at 13,000 g at 4 °C. Mitochondrial pellets corresponding to 1.5 μg proteins are separated by SDS-PAGE using 4-20% Tris-Gly gels (NONEX) and their respective contents of cytochrome c are estimated by Western blotting using polyclonal anti- cytochrome c antibody (dilution 1:2,500). Antigen-antibody complexes are detected using horseradish peroxidase-conjugated goat anti-rabbit IgG and enhance chemiluminescence detection reagents. The cytochrome c bands are scanned and quantified using a Bio-Rad (GS- 700 Imaging Densitometer). d) Effect of Compounds according to formula I onto the Release of Cytochrome c Trig-gered by Bid-Induced Bax Activation (in vitro assay) Concerning the Bid-induced activation of Bax leading to mitochondrial Cytochrome C release, it is referced to the description of Martinou et al. in The Journal of Cell Biology, Vol. 144, No. 5, March 8, 1999, pages 891-901. Mitochondria isolated from HeLa cells are incu- bated for 15 min at 30°C in 100 μl of KC1 buffer in the presence or absence of 10 nM recombinant Bid. The various compounds (10 μM) are pre-incubated for 5 min prior to addition of Bid. Following incubation, mitochondria were centrifuged for 5 min at 13000 g at 4°C and the supernatant is collected for cytochrome c analysis. Cytochrome c is detected by Western blotting. The cytochrome c bands are scanned and quantified using a Bio-Rad (GS-700 Imaging Densitometer). The above set out 2 in vitro assays c) and d) involving the determination of mitochondrial cytochrome c release are based on immunochemical methods using the Western blot analysis. Alternatively, said quantitative cytochrome c determinations may be performed by using spectrophotometric means : I. by recording the difference between reduced and oxidised cytochrome c by dual wavelength double beam spectrophotometry; π. by measuring the rather intensive γ or Soret peak in the spectrum of cytochrome c (ε = 100 mM^cm "1 ) is used for rapid and quantitative determination ofthe release of cytochrome c from isolated mitochondria. This technique allows a highly convenient, fast and reliable quantitative determination ofthe release of cytochrome c. e) Sympathetic Neuron Culture and Survival Assay (in vivo assay) Sympathetic neurons from superior cervical ganglia (SCG) of newborn rats (p4) are dissociated in dispase, plated at a density of 104 cells/cm 2 in 48 well MTT plates coated with rat tail collagen, and cultured in Leibowitz medium containing 5% rat serum, 0.75 g/ml NGF 7S (Boehringer Mannheim Corp., Indianapolis, IN.) and arabinosine 105M. Cell death is induced at day 4 after plating by exposing the culture to medium containing 10 g/ml of anti NGF antibody (Boehringer Mannheim Corp., Indianapolis, IN.) and no NGF or arabinosine, in the presence or absence of pyrrolidine derivatives inhibitors according to formula I. 24 hours after cell death induction, determination of cell viability is performed by incubation ofthe culture for 1 hour, at 37°C in 0.5 mg/ml of 3-(4,5-dimethyl-thiazol-2-yl)2,5 diphenyl tetrazolium bromide (MTT). After incubation in MTT cells are re-suspended in DMSO, transferred to a 96 MTT plate and cell viability is evaluated by meas-uring optical density at 590 nm. f) Biological Results - Discussion By using for instance compounds • (4EZ)-N -(2-hydroxyethyl)-4-(mefhoxyimino)-N -pentyl- 1,2-pyrrolidinedicarboxamide or • (2S,4EZ)-2- {[4-(l ,3-benzodioxol-5-ylmethyl)-l -piperazinyl]carbonyl} -4~(methoxy- imino)-N-pentyl-l -pyrrolidinecarboxamide (compound of Example 28) at a concentration of 10 μM in the above assay d) (Effect of Compounds according to formula I onto the Release of Cytochrome c Triggered by Bid-Induced Bax Activation), an inhibition of about 79% and 59% respectively was determined. According to a prefened embodiment the tested compounds of formula I display an inhibition ofthe cytochrome c release of at least 40 %, more prefened of at least 60% when tested at a concentration of between 2-50 μM, preferably between 5-20 μM and most prefened at 5-10 μM.

Claims: Claims 1. Pyrrolidine derivatives according to formula I I as well as its geometrical isomers, its optically active forms as enantiomers, diastereo- mers and its racemate forms, as well as pharmaceutically acceptable salts thereof, wherein X is selected from the group consisting of O, S, CR 6 R 7 , NOR 6 , NNR 6 R 7 ; A is selected from the group consisting of -(C=O)-, -(C=O)-O-, -C(=NH)-, -(C=O)-NH-, - (C=S)-NH, -SO 2 -, -SO 2 NH-, -CH 2 -, B is either a group -(C=O)-NR 8 R 9 or represents a heterocyclic residue having the formula wherein Q is NR , 10 , O or S; n is an integer selected of 0, 1 or 2; Y, Z and E form together with the 2 carbons to which they are attached a 5-6 membered aryl or heteroaryl ring, R 1 is selected from the group comprising or consisting of unsubstituted or substituted - C 6 -alkyl, unsubstituted or substituted C 2 -C 6 -alkenyl, unsubstituted or substituted C 2 -C 6 - alkynyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl, acyl, unsubstituted or substituted -Ce-alkyl aryl, unsubstituted or substituted d-C ό -alkyl heteroaryl, said cycloalkyl or aryl or heteroaryl groups may be fused with 1-2 further cycloalkyl or aryl or heteroaryl group; R 2 , R 3 , R 4 and R 5 are independently selected from each other from the group consisting of hydrogen, halogen, - -alkyl, - -alkoxy; R and R are independently selected from the group comprising or consisting of hydrogen, unsubstituted or substituted Cj-C 6 alkyl, unsubstituted or substituted C -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted thioalkoxy, halogen, cyano, nitro, acyl, alkoxycarbonyl, aminocarbonyl, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl which may contain 1 to 3 heteroatoms selected of N, O, S, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted C \ - C 6 -alkyl aryl, unsubstituted or substituted d-Cβ-alkyl heteroaryl; R 8 , R 9 and R 10 are independently selected from the group comprising or consisting of hydrogen, unsubstituted or substituted -C δ alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl which may contain 1 to 3 heteroatoms selected of N, O, S, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or each pair R 6 , R 7 and/or R 8 , R 9 could form together with the N atom to which they are attached a 3-8 membered substituted or unsubstituted, saturated or unsaturated hetero- cyclic ring which may contain 1-2 further heteroatoms selected from N, S and O and which is optionally fused with an aryl, heteroaryl or 3-8 membered saturated or unsaturated cycloalkyl ring; R 11 is selected from the group comprising or consisting of hydrogen, unsubstituted or substituted -C δ -alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, hydroxy, mercapto, alkoxy, thioalkoxy, aryl, heteroaryl, halogen, nitro, cyano, acyl, acyloxy, acylamino, aminocarbonyl, alkoxycarbonyl, sulfonyl, sulfoxy, carboxyl, primary, secondary or tertiary amino groups or quarternary ammonium moieties, unsubstituted or substituted saturated or unsaturated 3-8-membered cyclo-alkyl, with the proviso that if X is (=CH 2 ), A is -(C=O)-O-, R 1 is a t-butyl group, B could not be -(C=O)-NMe 2 , -(C=O)-NHMe, -(C=O)-NH-CH(Me)-(C=O)-NH-CH(Me)-COOH, - (C=O)-NH-CH(COOCH 2 -Ph)-CH 2 -COOPh; with the further proviso that if X is (=CHR 6 ) with R 6 being cyclohexylmethyl, A is - (C=O)-O-, R 1 is a t-butyl group, B could not be -(C=O)-NH-t-butyl; with the further proviso that if X is a C1-C20 alkylidene, A is -(C=O)-O-, R 1 is a t-butyl, B could not be with R being CrC 1 alkyl and Hal being Cl, Br, J; with the final proviso that if X is a C 1 -C 20 alkylidene, A-R 1 is a protective group, B could not be with R being H or d-C 12 alkyl with the final proviso that the following compounds are excluded : 2. A pyrrolidine derivative according to claim 1, wherein B is a group -(C=O)-NHR 9 , in which R 9 is selected from the group consisting of unsubstituted or substituted Q-Ce alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, unsubstituted or substituted saturated or unsaturated 3-6-membered cycloalkyl which optionally contains a N atom, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted C 1 -C 2 -alkyl aryl, unsubstituted or substituted C 1 -C 2 -alkyl heteroaryl. 3. A pynolidme derivative according to claim 1, wherein B is a fused heterocycle ofthe formula 4. A pynolidme derivative according to claim 2, wherein R 9 is a heteroaryl selected from pyridyl, pynolyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothia-zolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5- oxadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-triazinyl, 1,2,3-triazmyl, benzofuryl, [2,3- dihydro]benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, isobenzo-thienyl, 2,1,3- benzothiadiazolyl, 2,1,3-benzoxadiazolyl, benzodioxolyl, indolyl, isoindolyl, 3H-indolyl, benzimidazolyl, imidazo[l,2-a]pyridyl, benzothiazolyl, benzoxazolyl, quinolizinyl, quinazolinyl, phthalazinyl, quinoxalinyl, cinnnolinyl, napthyridinyl, pyrido[3,4-b]pyridyl, pyrido[3,2-b]pyridyl, pyrido[4,3-b]pyridyl, quinolyl, isoquinolyl, tetrazolyl, 5,6,7,8- tetrahydroquinolyl, 5,6,7,8-tetrahydroisoquinolyl, purinyl, pteridinyl, carbazolyl, xanthenyl, acridinyl or benzoquinolyl and whereby said heteroaryl could be fused with a 3-8-membered cycloalkyl containing optionally 1-3 heteroatoms selected from N, O, S. 5. A pynolidine derivative according to any ofthe preceding claims, wherein X is NOR 6 , and R is selected from the group consisting of H, unsubstituted or substituted Q-Cβ alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, unsubstituted or substituted acyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted saturated or unsaturated 3-8- membered cycloalkyl, unsubstituted or substituted d-C δ -alkyl aryl, unsubstituted or substituted d-C 6 -alkyl heteroaryl, said cycloalkyl or aryl or heteroaryl groups may be fused with 1-2 further cycloalkyl or aryl or heteroaryl groups. 6. A pyrrolidine derivative according to claim 5, wherein R 6 is H, CH 3 , unsubstituted or substituted CH 2 -phenyl or allyl, preferably H or methyl. 7. A pyrrolidine derivative according to any ofthe claims 1-4, wherein X is CHR 6 , R 6 is selected from the group consisting of halogen, cyano, unsubstituted or substituted C 3 -C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C -C 6 alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted thioalkoxy, nitro, acyl, alkoxycarbonyl, aminocarbonyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted saturated or unsaturated 3-8-membered cycloalkyl, unsubstituted or substituted d-Cβ-alkyl aryl, unsubstituted or substituted d- C -alkyl heteroaryl, said cycloalkyl or aryl or heteroaryl groups may be fused with 1-2 further cycloalkyl or aryl or heteroaryl groups. 8. A pynolidine derivative according to claim 7, wherein R 6 is selected from the group consisting of halogen, cyano, C 3 -C 6 alkyl or an unsubstituted or substituted phenyl group. 9. A pynolidine derivative according to any ofthe claims 1-4, wherein X is O. 10. A pyrrolidine derivative according to any ofthe preceding claims, wherein A is -(C=O)-, or -(C=O)-NH-, or -SO 2 -. 11. A pynolidine derivative according to claim 10, wherein A is -(C=O)-. 12. A pynolidine derivative according to any ofthe preceding claims, wherein R 1 is an d-C 6 - alkyl, C 2 -C 6 -alkenyl, unsubstituted or substituted C 2 -C 6 -alkynyl, aryl, heteroaryl, saturated or unsaturated 3-8-membered cycloalkyl, d-Ce-alkyl aryl, d-C 6 -alkyl heteroaryl. 13. A pynolidine derivative according to claim 12, wherein R 1 is an d-C 6 -alkyl or aryl group. 14. A pynolidine derivative according to claim 13, wherein R 1 is biphenyl. 15. A pynolidine derivative according to any of claims 1-5, wherein X is NOR 6 or =CHC1„ R 6 is a d-C 6 -alkyl or aryl or d-C 6 -alkyl aryl group, B is an amido group ofthe formula - (C=O)NHR 9 ), wherein R 9 is as above defined, A is C=O and R 1 is a d-C 6 -alkyl-aryl, an aryl or a d-C 6 -alkyl group. 16. A pynolidine derivative according to claim 15, wherein X is either =CH-C1, or =NOR 6 , R 6 is a methyl or phenyl group, B is an amido group ofthe formula -(C=O)NHR 9 ), wherein R 9 is a d-C 6 -alkyl-aryl , an aryl, a d-C 6 -alkyl which is substituted by a primary, secondary or tertiary amine, A is C=O and R 1 is a diphenyl methyl or a phenyl group. 17. A pyrrolidine derivative according to any ofthe preceding claims selected from the following group: (2S,4EZ 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-N-(2-mefhoxyethyl)-4-(methoxyimino)-2- pynolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biρhenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-(2-hydroxy-2-phenyl- efhyl)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-N-(2-hydroxyethyl)-4-(methoxyimino)-2- pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenefhyl]-4-(methoxy- imino)-2-pynolidinecarboxamide (3EZ,5S)-5-(lH-benzimidazol-2-yl)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-3-ρynolidinone O- methyloxime (2S,4EZ)-N-(2,l,3-benzothiadiazol-4-yl)-l-([l,r-biρhenyl]-4-ylcarbonyl)-4-(methoxy- imino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l, -biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-N-(6-quinolinyl)-2- pyrrolidinecarboxamide (2S,4EZ)-l-acetoacetyl-N-benzyl-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-1 -([1,1 '-biphenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-(2-furylmethyl)-2- pynolidinecarboxamide (2S,4EZ)-l-[(4-chlorophenoxy)acetyl]-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-[(2RS)-2- hydroxy-2-phenethyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-allyl-l -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2-pyrrolidine- carboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-4-(mefhoxyimino)-N-(2-thienylmethyl)-2- pynolidinecarboxamide (2S,4EZ)-4-(cyanomethylene)-N-(2-furylmethyl)- 1 -[(2-oxo-6-ρentyl-2H-ρyran-3- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-1 -([ 1 , 1 '-biρhenyl]-4-ylcarbonyl)-N-(2-furylmethyl)-4-(methoxyimino)-2- pynolidinecarboxamide (2S,4EZ)-l-acetyl-N-cyclopropyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidine- carboxamide (2S,4EZ)-N-(2-furylmethyl)-4-(methoxyimino)-l-[(2-oxo-6-pentyl-2H-ρyran-3-yl)- carbonyl] -2-pynolidinecarboxamide (2S,4EZ)-N-benzyl-l-([l,r-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-N-methyl-2- pyrrolidinecarboxamide (2S,4EZ)-l-(diphenylacetyl)-4-(ethoxyimino)-N-(2-thienylmethyl)-2-pynolidinecar- boxamide (2S,4EZ)-N-(2, 1 ,3-benzothiadiazol-4-yl)-4-(cyanomethylene)- 1 -(diphenylacetyl)-2- pyrrolidinecarboxamide (3EZ,5S)-5-(lH-benzimidazol-2-yl)-l-(diphenylacetyl)-3-pyrrolidinone O-methyloxime (2S)-2-[ 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-4-methylene-2-pynolidinyl] - IH-benzimidazole (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-(2-methoxyethyl)-2- pynolidinecarboxamide (3EZ,5S)-5-(lH-benzimidazol-2-yl)-l -(diphenylacetyl)-3-pyrrolidinone O-allyloxime (2S,4EZ)-l-([l,l , -biρhenyl]-4-ylcarbonyl)-N-[2-(diethylamino)ethyl]-4-(methoxyimino)- 2-pyrrolidinecarboxamide (2S,4EZ)-l-(diphenylacetyl)-4-{[(4-methoxybenzyl)oxy]imino}-N-(2-thienylmethyl)-2- pynolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-(3,4-dimethoxybenzyl)-4-(mefhoxyimino)-2- pynolidinecarboxamide (2S,4EZ)-l-acetoacetyl-4-(methoxyimino)-N-(l-naphthylmethyl)-2-pynolidinecarbox- amide (2S,4EZ)-N-allyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-l-(diphenylacetyl)-2- pyrrolidinecarboxamide (2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N 1 -pentyl-N 2 -(6-quinolinyl)-l,2-pyrroli- dinedicarboxamide (2S,4EZ)-4-(chloromethylene)-l-(diphenylacetyl)-N-[(2RS)-2-hydroxy-2-phenethyl]-2- pynoli-dinecarboxamide (2S)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenethyl]-4-methylene-2- pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-(chloromethylene)-N-(6-quinolinyl)-2- pynolidinecarboxamide (2S,4EZ)-4-benzylidene-N-[2-(diethylamino)ethyl]-l-(diphenylacetyl)-2-pynolidine- carboxamide (2S,4EZ)-l-acetoacetyl-4-(methoxyimino)-N-(2-thienylmethyl)-2-pynolidine- carboxamide (2S,4EZ)-l-acetyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-[(2RS)-2-hydroxy-2-ρhenethyl]- 2-pynolidinecarboxamide (2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N 1 -(3,5-dichlorophenyl)-N 2 -(6-quinolinyl)- 1 ,2-pynolidinedicarboxamide (2S,4EZ)-4-(methoxyimino)-N-(l -naphfhylmethyl)- 1 -(phenoxyacetyl)-2- pyrrolidinecarboxamide (2S,4EZ)-4-(chloromethylene)-N-(3 ,4-dimethoxybenzyl)- 1 -[(2-oxo-6-pentyl-2H-pyran-3- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-(diphenylacetyl)-4-(methoxyimino)-N-(2-thienylmethyl)-2-pynolidinecar- boxamide (2S,4EZ)-N-benzyl-l-(diphenylacetyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-1 -([1 , 1 *-biphenyl]-4-ylcarbonyl)-4- {[(3,4-dichlorobenzyl)oxy]imino} -N-[2- (diethylamino)ethyl]-2-pyrrolidinecarboxamide (2S,4EZ)-4- { [(3 ,4-dichlorobenzyl)oxy]imino} - 1 -[4-(dimethylamino)butanoyl] -N-(6- quinolinyl)-2-pynOlidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-(5-ethyl-l,3,4-thiadiazol-2-yl)-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-benzyl- 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-4-(methoxyimino)-2-ρynolidine- carboxamide (2S,4EZ)-N-benzyl-l-(diphenylacetyl)-4-(ethoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N 2 -cyclopropyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-N 1 -(3-methoxyphenyl)-l,2- pynolidinedicarboxamide (2S,4EZ)-l-(diphenylacetyl)-N-[(2RS)-2-hydroxy-2-phenethyl]-4-{[(4-methoxy- benzyl)oxy]-imino}-2-pynolidinecarboxamide (2S)-N-(2-furylmethyl)-4-methylene-l-[(2-oxo-6-pentyl-2H-pyran-3-yl)carbonyl]-2- pynolidinecarboxamide (2S,4EZ)-N-(2,l,3-benzothiadiazol-4-yl)-l-(diphenylacetyl)-4-(mefhoxyimino)-2- pynolidinecarboxamide (2S,4EZ)-N-benzyl-l-(diphenylacetyl)-4-{[(4-methoxybenzyl)oxy]imino}-2- pynolidinecarboxamide (2S,4EZ)- 1 -benzoyl-4- { [(3 ,4-dichlorobenzyl)oxy]imino} -N-(6-quinolinyl)-2- pyrrolidinecarboxamide (2S,4EZ)- 1 -acetoacetyl-N-cyclopropyl-4- {[(3 ,4-dichlorobenzyl)oxy]imino} -2- pynolidinecarboxamide (2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N 2 -[(2RS)-2-hydroxy-2-phenethyl]-N 1 - pentyl- 1 ,2-pyrrolidinedicarboxamide (2S,4EZ)-4-[(benzyloxy)imino]-N-(l-naphthylmethyl)-l-(phenoxyacetyl)-2- pyrrolidinecarboxamide (2S)- 1 -([ 1 , 1 '-biphenyl] -4-ylcarbonyl)-4-methylene-N-(6-quinolinyl)-2-ρyrrolidinecar- boxamide (2S,4EZ)-N-cycloρropyl-4-{[(3,4-dichlorobenzyl)oxy]imino}-l-(diphenylacetyl)-2- pynolidinecarboxamide (2S,4EZ)-l-(4-cyanobenzoyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-(6-quinolinyl)-2- pynolidinecarboxamide (2S,4EZ)-N-cyclopropyl-4- {[(3 ,4-dichlorobenzyl)oxy]imino} - 1 -(methoxyacetyl)-2- pynolidinecarboxamide (2S,4EZ)-N-(l,3-benzodioxol-5-ylmethyl)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4- (methoxyimino)-2-pyrrolidinecarboxamide (3EZ,5S)-5-[(4-acetyl-l-piperazinyl)carbonyl]-l-acryloyl-3-pyrrolidinone O-(3,4- dichlorobenzyl)oxime (2S)-1 -([1,1 '-biphenyl]-4-ylcarbonyl)-N-(2-furylmethyl)-4-methylene-2-pynolidinecar- boxamide (2S,4EZ)-4-(cyanomethylene)-N-(3,4-dimethoxybenzyl)-l-[(2-oxo-6-pentyl-2H-pyran-3- yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,r- biphenyl] -4-yl)carbonyl] -2-pynolidinecarboxamide (2S,4EZ)- 1-([ 1 , 1 '-biphenyl]-3-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-(4-benzoylbenzoyl)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-2- pyreolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-(3-ρhenoxybenzoyl)- 2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-(2-ρhenoxybenzoyl)- 2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2R)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-(2-hydroxyethyl)-4-(methoxyimino)-l -[(2'-methyl[ 1 , 1 '-biphenyl]-4- yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-(2-hydroxyethyl)-4-(mefhoxyimino)-N-methyl-l-[(2'-methyl[l,r-biphenyl]-4- yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(lS,2S,3R,4R)-3- (hydroxymethyl)bicyclo[2.2.1]hept-2-yl]-4-(mefhoxyimino)-2-pynolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-(tr n5-4-hydroxycyclohexyl)-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lR,2R)-2-(hydroxymethyl)cyclohexyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-3-phenoxypropyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-3-ρhenoxyρropyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-3-phenoxypropyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-(4- hydroxyphenyl)ethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-2-(4- hydroxyphenyl)ethyl]-4-(methoxyimino)-2-ρynolidinecarboxamide (2S,4EZ)-1 -([ 1 , 1 '-biρhenyl]-4-ylcarbonyl)-N-[(l -hydroxycyclohexyl)methyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(l-hydroxycyclohexyl)methyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pynolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylsulfonyl)-N-[(l-hydroxycyclohexyl)methyl]-4- (mefhoxyimino)-2-pynolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-(3,4-dihydroxyphenyl)-2- hydroxyefhyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[4-(4- pyridinyl)benzoyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[4-(2- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2,3-dihydroxypropyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2,3-dihydroxypropyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-3-(4- methoxyphenoxy)propyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-3-(4-methoxyphenoxy)propyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-3-(4- methoxyphenoxy)propyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxypropyl]-4-(methoxyimino)- 2-pynolidinecarboxamide (2S,4EZ)-1 -([1,1 '-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxypropyl]-4-(methoxyimino)- 2-pynolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-2-(2-naphthyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4-(methoxvimino)-l-[4-(4- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4-(methoxyimino)-l-[4-(2- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylsulfonyl)-N-[(2RS)-2-hydroxy-2-(4-nitrophenyl)ethyl]-4- (methoxyimino)-2-ρynolidinecarboxamide (2S,4EZ)-N-{(2RS)-3-[4-(acetylamino)phenoxy]-2-hydroxypropyl}-l-([l,r-biρhenyl]-4- ylcarbonyl)-4-(methoxyimino)-2-ρyrrolidinecarboxamide (2S,4EZ)-N- { (2RS)-3 -[4-(acetylamino)phenoxy] -2-hydroxypropyl} -4-(methoxyimino)- 1 - [4-(4-pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-{(2RS)-3-[4-(acetylamino)phenoxy]-2-hydroxypropyl}-4-(methoxyimino)-l- [4-(3-pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-{(2RS)-3-[4-(acetylamino)phenoxy]-2-hydroxypropyl}-l-([l,l'-biphenyl]-4- ylsulfonyl)-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(2R)-2-hydroxy-2-phenylethyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(2R)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[4-(4- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2R)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[4-(3- pyridinyl)benzoyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2R)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[4-(2- pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-1 -([ 1 ,1 '-biphenyl]-4-ylsulfonyl)-N-[(2R)-2-hydroxy-2-phenylethyl]-4- (methoxyimino)-2-ρynolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylcarbonyl)-N-(3-hydroxyproρyl)-4-(methoxyimino)-2- pynolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylsulfonyl)-N-(3-hydroxypropyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (3EZ,5S)-l-([l,l'-biphenyl]-4-ylcarbonyl)-5-[(4-hydroxy-4-phenyl-l- piρeridinyl)carbonyl]-3-pyrrolidinone O-methyloxime (3EZ,5S)-5-[(4-hydroxy-4-phenyl-l-piperidinyl)carbonyl]-l-[4-(4-pyridinyl)benzoyl]-3- pynolidinone O-methyloxime (3EZ,5S)-5-[(4-hydroxy-4-phenyl-l-ρiρeridinyl)carbonyl]-l-[4-(3-ρyridinyl)benzoyl]-3- pynolidinone O-methyloxime (3EZ,5S)-l-([l,l'-biphenyl]-4-ylsulfonyl)-5-[(4-hydroxy-4-phenyl-l- piperidinyl)carbonyl]-3-pynolidinone O-methyloxime (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lS,2S)-2-hydroxycyclohexyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylsulfonyl)-N-[(lS,2S)-2-hydroxycyclohexyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-benzyl-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-(2-hydroxyethyl)-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-benzyl-N-(2-hydroxyethyl)-4-(methoxyimino)-l-[4-(3-pyridinyl)benzoyl]-2- pyrrolidinecarboxamide (3EZ,5S)-1 -([1 , 1 '-biρhenyl]-4-ylcarbonyl)-5- {[(3RS)-3-hydroxypiperidinyl]carbonyl} -3- pyrrolidinone O-methyloxime (3EZ,5S)-5-{[(3RS)-3-hydroxyρiρeridinyl]carbonyl}-l-[4-(4-pyridinyl)benzoyl]-3- pynolidinone O-methyloxime (3EZ,5S)-5-{[(3RS)-3-hydroxypiρeridinyl]carbonyl}-l-[4-(3-pyridinyl)benzoyl]-3- pynolidinone O-methyloxime (3EZ,5S)-l-([l,l'-biρhenyl]-4-ylsulfonyl)-5-{[(3RS)-3-hydroxypiperidinyl]carbonyl}-3- pyrrolidinone O-methyloxime (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2- ρhenylethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-ρhenylethyl]-4-(methoxyimino)-l- [4-(4-pyridinyl)benzoyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-phenylethyl]-4-(methoxyimino)-l- [4-(3-pyridinyl)benzoyl]-2-pynolidinecarboxamide (2S,4EZ)-1 -([ 1 , 1 '-biphenyl]-4-ylsulfonyl)-N-[(lS,2S)-2-hydroxy-l -(hydroxymethyl)-2- phenylethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-l-([l,r-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2- pynolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-4-(methoxyimino)-l-[4-(4-pyridinyl)benzoyl]-2- pynolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-4-(methoxyimino)-l-[4-(3-ρyridinyl)benzoyl]-2- pynolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-4-(methoxyimino)-l-[4-(2-ρyridinyl)benzoyl]-2- pynolidinecarboxamide (2S,4EZ)-N-(2-anilinoethyl)-l-([l,l'-biphenyl]-4-ylsulfonyl)-4-(methoxyimino)-2- pynolidinecarboxamide (3EZ,5S)-1 -([1 ,1 '-biphenyl]-4-ylcarbonyl)-5-[(4-hydroxy-l -piperidinyl)carbonyι]-3- pynolidinone O-methyloxime (3EZ,5S)- 1 -([ 1 , 1 '-biρhenyl]-4-ylsulfonyl)-5-[(4-hydroxy- 1 -piρeridinyl)carbonyl]-3- pyrrolidinone O-methyloxime (2S,4EZ)-N-[(lS,2R,3S,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-l-([l,l'- biphenyl]-4-ylsulfonyl)-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-(3-amino-3-oxopropyl)-l-([l,r-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2- pynolidinecarboxamide (2S,4EZ)-N-[(lS,2S,3R,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-l-([l,l'- biphenyl]-4-ylsulfonyl)-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l , -biphenyl]-4-ylcarbonyl)-N-(4-hydroxybutyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biρhenyl]-4-ylsulfonyl)-N-(4-hydroxybutyl)-4-(methoxyimino)-2- pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylsulfonyl)-N-[(lR,2R)-2-(hydroxymethyl)cyclohexyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-1-([1 ,1 '-biphenyl]-4-ylsulfonyl)-N-[(lR,2S,3R,4S)-3- (hydroxymethyl)bicyclo[2.2.1]hept-2-yl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biρhenyl]-4-ylsulfonyl)-N-[(lR,2S)-2-(hydroxymethyl)cyclohexyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4E and 4Z)-N-[(2RS)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,r- biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4E and 4Z)-N-[(2S)-2-hydroxy-2-ρhenylethyl]-4-(mefhoxyimino)-l-[(2'-methyl[l ,1'- biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4E and 4Z)-N-[(2R)-2-hydroxy-2-ρhenylethyl]-4-(methoxyimino)-l -[(2'-methyl[l ,1 '- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lR,2S)-2-(hydroxymethyl)cyclohexyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[2-hydroxy-l-(hydroxymethyl)ethyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(lS,2R,3S,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-l-([l,l*- biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(lS,2S,3R,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-l-([l,l'- biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)- 1 -([ 1 , 1 '-biphenyl]-4-ylcarbonyl)-N-[(2S)-2-hydroxy-2-phenylefhyl]-4- (methoxyimino)-2 -pyrrolidinecarboxamide (2RS)-3-({[(2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)pynolidinyl]- carbonyl} amino)-2-hydroxypropanoic acid (2S,4EZ)-N-[(lR,2S)-2-(aminocarbonyl)cyclohexyl]-l-([l,l'-biphenyl]-4-ylcarbonyl)-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lRS)-2-hydroxy-l-methylethyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-(4- nitrophenyl)ethyl]-4-(methoxyimino)-2-pynolidinecarboxamide 4-({[(2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)pyrrolidinyl]- carbonyl} amino)butanoic acid (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-l-[(2'-methoxy[l,l'-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(2-naphthyl)ethyl]-l-[(2'-methoxy[l,r-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(lRS)-2-hydroxy-l-methylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l*- biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-4- (methoxyimino)- 1 -[(2'-methyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl] -2-pynolidinecarboxamide (2S,4EZ)-N-[(lS,2S)-2-hydroxy-l-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-4- (methoxyimino)- 1 - [(2*-methoxy [ 1 , 1 '-biphenyl] -4-yl)carbonyl] -2-pynolidine-carboxamide (3EZ,5S)-5-[(4-hydroxy-l-piperidinyl)carbonyl]-l-[(2*-methyl[l,l'-biphenyl]-4- yl)carbonyl]-3-pynolidinone O-methyloxime (2S,4EZ)-N-[(lS,2S,3R,4R)-3-(aminocarbonyl)bicyclo[2.2.1]hept-5-en-2-yl]-4- (methoxyimino)-l -[(2'-methyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl]-2-pyrroli dinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-phenylethyl]-l-[(2'-methoxy[l,l'-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxypropyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2,3-dihydroxypropyl]-4-(methoxyimino)-l-[(2*-methyl[l,l'-biphenyl]- 4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-(3-hydroxypropyl)-4-(methoxyimino)-l-[(2'-methyl[l,l'-biphenyl]-4- yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-(2-amino-2-oxoethyl)-l-([l,r-biphenyl]-4-ylcarbonyl)-4-(methoxyimino)-2- pynolidinecarboxamide (2S,4EZ)-N-(2-amino-2-oxoefhyl)-4-(methoxyimino)-l-[(2*-methyl[l,l*-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-1-([1 ,1 '-biρhenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)- ethyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-([l,r-biphenyl]-4-ylcarbonyl)-N-[(lS,2R,3S,4R)-3-(hydroxymethyl)- bicyclo [2.2.1 ]hept-2-yl] -4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(lR,2S,3R,4S)-3-(hydroxymethyl)bicyclo[2.2.1]hept-2-yl]-l-[(2'- methoxy[l, -biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-(tran5-4-hydroxycyclohexyl)-l-[(2'-methoxy[l,l'-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(lR,2R)-2-(hydroxymethyl)cyclohexyl]-l-[(2*-methoxy[l,r-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-3-phenoxypropyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'- biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-hydroxyρhenyl)ethyl]-4-(methoxyimino)-l-[(2'- methyl[ 1 , 1 '-biphenyl] -4-yl)carbonyl] -2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(2'- methoxy[ 1 , 1 '-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-l-[(2'-methyl[l,l'- biphenyl] -4-yl)carbonyl] -4-(methoxyimino)-2-ρyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-l-[(2'-methoxy[l,r- biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-l-[(2'-methoxy[l,r- biphenyl] -4-yl)carbonyl] -4-(mefhoxyimino)-2-pyrrolidinecarboxamide (2R,4EZ)-l-([l,l*-biphenyl]-4-ylcarbonyl)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2R,4EZ)-N-[(2RS)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2'-methyl[l,l'- biphenyl]-4-yl)carbonyl]-2-ρynolidinecarboxamide (2S,4EZ)-l-[(2'-cyano[l,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-phenylethyl]- 4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-[(3',4'-dichloro[l,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2- phenylethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2- phenylethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,l*-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2- phenylethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(2'- methyl[l , 1 '-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hychoxyphenyl)ethyl]-4-(methoxyimino)-l-[(2'- cyano[l, -biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(3',4'- dichlorofl , 1 '-biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(2',6'- dimethyl[ 1 , 1 '-biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2RS)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-4-(methoxyimino)-l-[(2',3- dimethylf 1 , 1 '-biphenyl] -4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-l-[(3',4'-dichloro[l,l'-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-(4- hydroxyphenyl)efhyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimethyl[l,l*-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-(4- hydroxyphenyl)ethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-1 -[(2' ,3-dimethyl[l , 1 '-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-2-(4- hydroxyphenyl)ethyl] -4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-3-(4- methoxyphenoxy)propyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[(2RS)-2-hydroxy-3-(4- methoxyphenoxy)propyl]-4-(methoxyimino)-2-ρyrroli dinecarboxamide (2S,4EZ)-N-(2-amino-2-oxoethyl)-l -[(2',6'-dimethyl[ 1 , 1 '-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-(2-amino-2-oxoethyl)-l-[(2',3-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-(3-amino-3-oxopropyl)-l-[(2',6'-dimethyl[l,l*-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-(3-amino-3-oxopropyl)-l-[(2',3-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-4- (methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[2-hydroxy-l- (hydroxymethyl)ethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[2-hydroxy-l- (hydroxymethyl)ethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-[(2'-cyano[l,r-biphenyl]-4-yl)carbonyl]-N-[(lR,2R)-2-(hydroxymethyl)- cyclohexyl]-4-(methoxyimino)-2-pynolidinecarboxamide (3EZ,5S)-5-(3,4-dihydro-2(lH)-isoquinolinylcarbonyl)-l-[(2',3-dimethyl[l,l'-biphenyl]-4- yl)carbonyl] -3 -pynolidinone O-methyloxime (2S,4EZ)-N-[(lR)-2-hydroxy-l-phenylethyl]-4-(methoxyimino)-l-[(2*-methyl[l,r- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[2-(4-hydroxyphenyl)ethyl]- 4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2*,3-dimethyl[l,l*-biphenyl]-4-yl)carbonyl]-N-[2-(4-hydroxyphenyl)ethyl]- 4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',6'-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[2-(3-hydroxyphenyl)ethyl]- 4-(methoxyimmo)-2-pynolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,r-biphenyl]-4-yl)carbonyl]-N-[2-(3-hydroxyphenyl)efhyl]- 4-(methoxyimino)-2-pyrrolidinecarboxamide (2S,4EZ)-l-[(2',3-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-N-[(lR,2S)-2-hydroxy-l,2- diρhenylethyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2RS)-2-[({(2S,4EZ)-4-(methoxyimino)-l-[(2*-methyl[l,l'-biphenyl]-4- yl)carbonyl]pynolidinyl}carbonyl)amino]-3-phenylpropanoic acid (2S,4EZ)-N-[(lR,2S)-2-(aminocarbonyl)cyclohexyl]-l-[(2',6'-dimethyl[l,l'-biphenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(lR,2S)-2-(aminocarbonyl)cyclohexyl]-l-[(2',3-dimethyl[l,l*-biρhenyl]-4- yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide 4'- {[(2S,4EZ)-2- {[4-(2-hydroxyethyl)-l -piperazinyljcarbonyl} -4- (methoxyimino)pynolidinyl]carbonyl} [1,1 '-biphenyl]-2-carbonitrile (3EZ,5S)-l-[(3',4'-dichloro[l,l'-biphenyl]-4-yl)carbonyl]-5-{[4-(2-hydroxyethyl)-l- piperazinyl]carbonyl} -3 -pynolidinone O-methyloxime (3EZ,5S)-l-[(2',6'-dimefhyl[l,l'-biphenyl]-4-yl)carbonyl]-5-{[4-(2-hydroxyethyl)-l- piperazinyl] carbonyl} -3 -pynolidinone O-methyloxime (3EZ,5S)-l-[(2',3-dimethyl[l,l'-biphenyl]-4-yl)carbonyl]-5-{[4-(2-hydroxyethyl)-l- piperazinyl]carbonyl} -3 -pynolidinone O-methyloxime (3EZ,5S)-l-[(2'-methyl[l,l*-biphenyl]-4-yl)carbonyl]-5-({4-[4-(trifluoromethyl)-phenyl]- 1 -piperazinyl} carbonyl)-3-pyrrolidinone O-methyloxime (3EZ,5S)-l-[(2'-methyl[l,l'-biphenyl]-4-yl)carbonyl]-5-({4-[3-(trifluoromethyl)-phenyl]- l-piperazinyl}carbonyl)-3-ρynolidinone O-methyloxime (2S,4EZ)-4-(methoxyimino)-l-[(2'-methyl[l,l*-biphenyl]-4-yl)carbonyl]-2- pynolidinecarboxamide (2S,4EZ)-4-(methoxyimino)-N-mefhyl-l-[(2'-methyl[l,r-biphenyl]-4-yl)carbonyl]-2- pynolidinecarboxamide (2S,4EZ)-4-(mefhoxyimino)-N r N-dimethyl-l-[(2'-methyl[l,l'-biphenyl]-4-yl)carbonyl]-2- pyrrolidinecarboxamide (2S,4EZ)-N-[(3R)-3-hydroxy-3-phenylpropyl]-4-(methoxyimino)-l-[(2'-methyl[l,r- biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(3S)-3-hydroxy-3-phenylproρyl]-4-(methoxyimino)-l-[(2'-methyl[l,r- biphenyl]-4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(3R)-3-hydroxy-3-phenylpropyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-l-([l,l'-biphenyl]-4-ylcarbonyl)-N-[(3S)-3-hydroxy-3-phenylproρyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(mefhoxyimino)-l - {[2'- (trifluoromethyl) [1,1 '-biphenyl] -4-yl] carbonyl} -2-pynolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-{[2*-chloro[l,l'- biphenyl]-4-yl]carbonyl}-2-pynolidinecarboxamide (2S,4EZ)-N-(2-hydroxyphenyl)-4-(methoxyimino)-l-[(2'-methyl[l,l'-biphenyl]-4- yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4EZ)-N-[2-(hydroxymethyl)phenyl]-4-(methoxyimino)-l-[(2"-methyl[l,r-biphenyl]- 4-yl)carbonyl]-2-pynolidinecarboxamide (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-l-[(2-methyl[l,r- biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (2S,4E and 4Z)-l-([l,l*-biρhenyl]-4-ylcarbonyl)-N-[(2S)-2-hydroxy-2-phenylethyl]-4- (methoxyimino)-2-pynolidinecarboxamide (2S,4EZ)-4-(methoxyimino)-l-[(2'-methyl[l,l'-biρhenyl]-4-yl)carbonyl]-N-(2- phenylethyl)-2-pyrrolidinecarboxamide (2S)- 1 -(diphenylacetyl)-N-( 1 -naphthylmethyl)-4-oxo-2-pynolidinecarboxamide (2S)-Nl-(3,5-dichlorophenyl)-N2-(3,4-dimethoxybenzyl)-4-oxo-l,2-pyrrolidine- dicarboxamide (2S)-4-oxo-l-(phenoxyacetyl)-N-[2-(lH-pynol-l-yl)phenyl]-2-pynOlidinecarboxamide 18. A pynolidine derivative according to any ofthe preceding claims selected from the following group: (4EZ)-1 -([1,1 '-biρhenyl]-4-ylcarbonyl)-N-[2-(diethylamino)ethyl]-4- {[(4-methoxy- benzyl)-oxy]imino}-2-pyrrolidinecarboxamide (4EZ)-N 2 -(2-hydroxyethyl)-4-(methoxyimino)-N 1 -pentyl- 1 ,2-pyrrolidinedicarboxamide (4EZ)-4-benzylidene-l-([l,l'-biρhenyl]-4-ylcarbonyl)-N-[2-(diethylamino)ethyl]-2- pynolidinecarboxamide (4EZ)-4-[(allyloxy)imino]- 1 -(4-cyanobenzoyl)-N-[2-( lH-pyrrol- 1 -yl)phenyl] -2-pyrrolidinecarboxamide (4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-N-(2-furylmethyl)-l-[(2-oxo-6-pentyl-2H- pyran-3-yl)carbonyl]-2-pyrrolidinecarboxamide (4EZ)-4-(methoxyimino)-N 1 -(3 -methoxyphenyl)-N 2 -(2-thienylmefhyl)- 1 ,2-pynolidine- dicarboxamide (4EZ)-2- { [4-( 1 ,3 -benzodioxol-5 -yhnethyl)- 1 -piperazinyl] carbonyl} -4-(methoxyimino)-N- pentyl- 1 -pyrrolidinecarboxamide (2S,4EZ)-N-(2-hydroxyethyl)-4-(methoxyimino)-l-nonanoyl-2-pynolidine-carboxamide. 19. A pynolidine derivative according any of claims 1 to 18 for use as a medicament, with the proviso that the following compounds are excluded 20. Use of a pyrrolidine derivative according to any of claims 1 to 18 for the treatment of neuronal disorders including epilepsy, Alzheimers disease, Huntingtons disease, Parkinsons disease, retinal diseases; spinal cord injury, Crohn's disease, head trauma, spinocerebellar ataxias and dentatorubral-pallidoluysian atrophy. 21. Use of a pynolidine derivative according to any of claims 1 to 18 for the treatment of autoimmune diseases including Multiple Sclerosis, amyotrophic lateral sclerosis, retinitis pigmentosa, inflammatory bowel disease (IBD), rheumatoid arthritis, asthma, septic shock, transplant rejection, AIDS. 22. Use of a pyrrolidine derivative according to any of claims 1 to 18 for the treatment of ischemia, like stroke, myocardial infarction and reperfusion injury, cardiovascular disorders, arteriosclerosis, heart failure, heart transplantation, renal hypoxia, hepatitis. 23. Use of a pyrrolidine derivative according to any of claims 1 to 18 for the treatment of infertility related disorders including premature menopause, ovarian failure and follicular atresia. 24. Use of a pynolidine derivative according to any of claims 1 to 18 for the preparation of a pharmaceutical composition for the modulation ofthe Bax function or the Bax activation. 25. Use according to claim 24 for the preparation of a pharmaceutical composition for the treatment and/or prevention of disorders associated with the abnormal expression or activity of Bax by inhibition of the Bax function or the Bax activation. 26. Use of a pynolidine derivative according to any of claims 1 to 18 for the preparation of a pharmaceutical composition for oral admimstration. 27. A pharmaceutical composition containing at least one pynolidine derivative according to any ofthe claims 1 to 18 and a pharmaceutically acceptable carrier, diluent or excipient thereof. 8. Process for the preparation of a pyrrolidine derivative according to any of claims 1 to 18, wherein the following reaction is performed : la whereby LG is a leaving group and the substituents R^R 9 , A and X are as above defined. 29. Process for the preparation of a pyrrolidine derivative according to any of claims 1 to 18, wherein the following reaction is performed : XV lb whereby LG is a leaving group and the substituents R^R 5 , R 11 , A, E, Q, X, Y and Z are as above defined. 30. Process according to claim 29, wherein compound XV is obtained as follows XIII XIV N-Deprotection XV

Inventors: BAXTER ANTHONY, BOMBRUN AGNES, HALAZY SERGE, QUATTROPANI ANNA, SCHWARZ MATTHIAS, THOMAS RUSSEL, BAXTER, ANTHONY, BOMBRUN, AGNES, HALAZY, SERGE, QUATTROPANI, ANNA, SCHWARZ, MATTHIAS, THOMAS, RUSSEL
Applicants: APPLIED RESEARCH SYSTEMS, BAXTER ANTHONY, BOMBRUN AGNES, HALAZY SERGE, QUATTROPANI ANNA, SCHWARZ MATTHIAS, THOMAS RUSSEL, APPLIED RESEARCH SYSTEMS ARS HOLDING N.V., BAXTER, ANTHONY, BOMBRUN, AGNES, HALAZY, SERGE, QUATTROPANI, ANNA, SCHWARZ, MATTHIAS, THOMAS, RUSSEL
Application year: 2001
Main classification: C07D207
IPC codes: A61K31, A61P1, A61P9, A61P11, A61P15, A61P21, A61P25, A61P27, A61P29, A61P31, A61P37, C07D207, C07D401, C07D403, C07D405, C07D409, C07D417