MACROLIDE ANTIBIOTICS

Abstract: The present invention relates to 11,12 gamma lactone ketolides of formula (I) wherein R, R<1>, R<2>, R<3> are as defined herein and pharmaceutically acceptable salts and solvates thereof, to process for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.

Description: MACROLIDE ANTIBIOTICS The present invention relates to novel semi-synthetic macrolides having antibacterial activity. More particularly this invention relates to 11,12 γ lactone ketolides, to processes for their preparation, to compositions containing them and to their use in medicine. EP 1114826 inter alia generically discloses macrolide compounds of formula (A) having antibacterial activity (A) wherem Ri is hydrogen or a hydroxyl protecting group; R4 is inter alia an optionally substituted Ci _ Q alkyl, X\ is inter alia oxygen, X2 is inter alia CE-2, Y is NH, O or S, R5 is inter alia C(O) and Ri 3 is hydrogen or halo. We have now found novel 11,12 γ lactone ketolides having antibacterial activity. Thus, the present invention provides compounds of general formula (I) (I) wherein R is hydrogen, cyano, (CH2) n A-X-R4 or (CH2) n R5; A is a group selected from -N(R 6 )-, -N[C(0)R 6 ]-, -N(R 6 )C(0)-, -N(R 6 )S(0) 2 - N(R 6 )C(0)0-, -N=C(R 6 )- or -N(R 6 )C(Y)N(R 7 )-; Ri is C . alkyl or C3_g alkenyl; R2 is hydrogen or a hydroxyl protecting group; R3 is hydrogen or halogen; X is a bond, a C 0 alkylene, a C2-.10 alkenylene or a C2-.10 alkynylene chain wherein said chains are: i) optionally interrupted by a bivalent radical group selected from -0-, -N(Rg)-, - C(O)-, -N(R 8 )C(Y)N(R 9 , -S(0)m-, -N(R 8 )C(0)-, -C(0)N(R 8 )-, -N(R 8 )C(0)C(0)-, -C(0)0- or -C(NOR 6 )- and/or ii) optionally substituted by one or two groups selected from: C1.4 alkyl, oxo, Cι _4 alkoxy, halogen, cyano, phenoxy, hydroxy, NR 8 R 9 , N(Rg)C(0)R 9 , =NORg, NR 8 C(Y)TSfR 9 or optionally substituted phenyl; R4 is selected from: hydrogen, optionally substituted phenyl, optionally substituted C3.7 cycloalkyl, optionally substituted 9 to 10 membered fused bicyclic carbocyclic, optionally substituted 5 or 6 membered heteroaryl in which the 5 -membered heteroaryl contains at least one heteroatom selected from oxygen, sulphur or nitrogen and the 6- membered heteroaryl group contains from 1 to 3 nitrogen atoms, optionally substituted 5-6 membered heterocyclic, or R4 is an optionally substituted 9 or 10 membered fused bicyclic heterocyclic having at least one heteroatom selected from oxygen, sulphur or nitrogen; R5 is a 5 or 6 membered heterocyclic containing at least one nitrogen, optionally substituted by one or two groups selected from oxo or 9 or 10 membered fused bicyclic heterocyclic having at least one heteroatom selected from oxygen, sulphur or nitrogen; Rg and R7 are independently hydrogen, C1.4 alkyl or phenyl which is optionally substituted by one or two C1.4 alkyl groups; R 8 and R9 are independently hydrogen, phenyl (which may be substituted by one or two C1 _ 4 alkyl) or R 8 and R9 are independently Ci .4 alkyl which is optionally substituted by 1 or 2 groups selected from: phenyl, Ci .4 alkoxy, cyano, 5 -membered heteroaryl containing 1 or 2 heteroatoms selected from oxygen, sulphur or nitrogen or the 6-membered heteroaryl group contains from 1 to 3 nitrogen atoms, hydroxy, oxo, carboxy; Y is an oxygen or a sulphur atom; n is 0 or an integer from 1 to 3; m is 0, 1 or 2; and pharmaceutically acceptable salts and solvates thereof. A further embodiment of the invention provides compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, (I) wherein R is (CH 2 ) n A-X-R 4 ; A is a group selected from -N(R 5 )-, -N(R 5 )C(0)-, -N(R 5 )S(0) 2 -, or -N(R 5 )C(Y)N(R 6 )-; R is hydrogen, Ci _g alkyl or C3_g alkenyl; R2 is hydrogen or a hydroxyl protecting group; R3 is hydrogen or halogen; X is optionally substituted C1 0 alkylene chain interrupted by a bivalent radical group selected from -0-, -N(R 5 )-, -C(O)-, -N(R 5 )C(Y)N(R 6 )-, -S(0)m-, -N(R 5 )C(0)-, - C(0)N(R 5 )-, -N(R5)C(0)C(0)-, -C(O)0- or -C(NOR 7 )- or X is optionally substituted C2.10 alkenylene or optionally substituted C2 0 alkynylene chain wherein said C2 0 alkenylene or C2 0 alkynylene chains are optionally interrupted by a bivalent radical group selected from -0-, -N(R 5 )-, -C(0 , -N(R 5 )C(Y)N(R 6 )-, -S(0)m-, - N(R 5 )C(0)-, -C(0)N(R 5 )-, -N(R5)C(0)C(0)-, -C(0)0- or -C(NOR 7 )-; R4 is selected from: hydrogen; optionally substituted phenyl; optionally substituted C 3.7 cycloalkyl; optionally substituted 9 to 10 membered aromatic fused bicyclic carbocyclic ring; optionally substituted 5 or 6 membered heteroaryl in which the 5-membered heteroaryl contains at least one heteroatom selected from oxygen, sulphur or nitrogen and the 6- membered heteroaryl group contains from 1 to 3 nitrogen atoms; optionally substituted 5-6 membered heterocyclic, or R4 is optionally substituted fused bicyclic heteroaryl groups containing 9 or 10 ring members having at least one heteroatom selected from oxygen, sulphur or nitrogen; R5 and Rg are independently hydrogen, phenyl (which may be substituted by one or two C j . 4 alkyl) or a nitrogen protecting group or R5 and Rg are independently Ci .4 alkyl which is optionally substituted by 1 or 2 groups selected from: phenyl, C1..4 alkoxy, Ci .4 alkyl, cyano, nitro, 5 -membered heteroaryl containing 1 or 2 heteroatoms selected from oxygen, sulphur or nitrogen and the 6-membered heteroaryl group contains from 1 to 3 nitrogen atoms; hydroxy, oxo, carboxy; R is hydrogen, C\ .4 alkyl or phenyl; Y is an oxygen or a sulphur atom; n is 0 or an integer from 1 to 5; m is 0, 1 or 2; Yet a further embodiment of the invention provides compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, (I) wherein R is hydrogen, cyano or (CH2) n A(CH2) m R4; Rj is Ci _g alkyl or C3..6 alkenyl; R2 is hydrogen or a hydroxyl protecting group; R3 is hydrogen or halogen; R4 is selected from: hydrogen; optionally substituted phenyl; optionally substituted 9 to 10 membered aromatic fused bicyclic carbocyclic ring; optionally substituted 5 or 6 membered heteroaryl in which the 5 -membered heteroaryl contains at least one heteroatom selected from oxygen, sulphur or nitrogen and the 6-membered heteroaryl group contains from 1 to 3 nitrogen atoms; or R4 is optionally substituted fused bicyclic heteroaryl groups containing 9 or 10 ring members having at least one heteroatom selected from oxygen, sulphur or nitrogen; A is a bond or a group selected from N(R 5 ), N[C(0)R 5 ], N(R 5 )C(0), N(R 5 )S(O 2 ), N(R 5 )C(0)0, N=C(R 6 ) or N(R 5 )C(X)N(R 6 ); R5 and Rg are independently hydrogen, phenyl, or Ci .4 alkyl; X is an oxygen or a sulphur atom; n or m are independently 0 or an integer from 1 to 5 with the proviso that the sum of n and m is 0 or an integer from 1 to 5; and pharmaceutically acceptable salts and solvates thereof. Suitable pharmaceutically acceptable salts of the compounds of general formula (I) include acid addition salts formed with pharmaceutically acceptable organic or inorganic acids, for example hydrochlorides, hydrobromides, sulphates, alkyl- or arylsulphonates (e.g. methanesulphonates or p-toluenesulphonates), phosphates, acetates, citrates, succinates, tartrates, fumarates and maleates. The compound of formula (I) and salts thereof may form solvates and the invention includes all such solvates. The solvates may, for example, be hydrates. References hereinafter to a compound according to the invention include both compounds of formula (I) and their pharmaceutically acceptable acid addition salts together with pharmaceutically acceptable solvates. In the general formula (I) as drawn, the solid wedge shaped bond indicates that the bond is above the plane of the paper. The broken bond indicates that the bond is below the plane of the paper. It will be appreciated by those skilled in the art that the compounds of formula (I) when R is not hydrogen contain at least one chiral centre (namely the carbon atom shown as 21 in formula (I)) and this may be represented by the formulae (la) and (lb). The configuration for the carbon atom shown as 21 in formula la is hereinafter referred to as the β configuration and in formula lb as the 2 lα configuration. la lb It is to be understood that the two diastereoisomers (la, lb) and mixtures thereof are encompassed within the scope of the present invention. Compounds wherein R2 represents a hydroxyl protecting group are in general intermediates for the preparation of other compounds of formula (I). When the group OR2 is a protected hydroxyl group this is a non-toxic protecting group, conveniently OR2 is an acyloxy group (i.e. acetoxy or benzyloxy). The term Ci .4 alkyl as used herein as a group or a part of the group refers to a straight or branched alkyl group containing from 1 to 4 carbon atoms; examples of such groups include methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl and tert-butyl. The term Ci _IQ alkylene chain refers to straight or branched chain containing from 1 to 10 carbon atoms examples of such group include, but are not limited to methylene, ethylene, propylene, isopropylene, n-butylene, isobutylene, tert-butylene, pentylene, n-heptylene, n- octylene, n-nonylene and n-decylene. The term C2.10 alkenylene chain refers to a straight or branched alkylene chain containing from 2 to 12 carbon atoms and having at least one double bond; examples of such groups include ethylene, 2-ρropenylene, 1-propenylene, isopropenylene, 2-butenylene, 2- pentenylene, 2-hexenylene and the like. The term C2-I0 alkynylene chain refers to a straight or branched alkylene chain containing from 2 to 12 carbon atoms and having at least one triple bond; examples of such groups include ethynylene, 2-propynylene, 1-propynylene, isopropynylene, 2-butynylene, 2- pentynylene, 2-hexenylene and the like. The term halogen refers to a fluorine, chlorine, bromine or iodine atom. When R4 is a 5 or 6 membered heteroaryl group according to the invention this includes furanyl, thiophenyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, pyrazolyl, isoxazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,3-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-triazolyl, 1,3,4- oxadiazolyl, 1,3,4-thiadiazolyl, 1,2,5-oxadiazolyl, 1,2,5-thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, 1,2,4 oxadiazolyl, 1,2,5-triazinyl or 1,3,5-triazinyl and the like. The term 9 to 10 membered fused bicyclic heterocyclic group refers to a 5,6/6,5 or 6,6 bicyclic ring system, containing at least one heteroatom selected from oxygen, sulphur or nitrogen, which may be saturated, unsaturated or aromatic. The term 9 to 10 membered fused bicyclic heterocyclic group also refers to a phenyl fused to one 5 or 6 membered heterocyclic group. Example of such groups include benzofuranyl, benzothiophenyl, indolyl, benzoxazolyl, 3H-imidazo[4,5-c]pyridin-yl, dihydrophthazinyl, lH-imidazo[4,5-c]pyridin-l- yl ,imidazo[4,5-b]pyridyl, 1,3 benzo[l,3]dioxolyl, 2H-chromanyl, isochromanyl, 5-oxo-2,3 dihydro-5H-[l,3]thiazolo[3,2-a]pyrimidyl, 1,3-benzothiazolyl, 1,4,5,6 tetrahydropyridaziyl, 1,2,3,4,7,8 hexahydropteridinyl, 2-thioxo2,3,6,9-tetrahydro-lH-purin-8-yl, 3,7-d_hydro-lH- purin-8-yl, 3,4 dihydropyrimidin-1-yl, 2,3 -dihydro-l,4-benzodioxinyl, benzo[l,3]dioxolyl, 2H-chromenyl, chromanyl, 3,4-dihydrophthalazinyl, 2,3 dihydro-lH-indolyl, l,3-dihydro-2H- isoindol-2-yl, 2,4J-trioxo-l,2,3,4,7,8-hexahydropteridinyl, thieno[3,2-d]pyrimidinyl, 4-oxo- 4J-dihydro-3H-pyrrolo[2,3-d]pyrimidinyl, 1,3 dimethyl-6-oxo-2-thioxo-2,3,6,9-tetrahydro- lH-purinyl, 1,2 dihydroisoquinolinyl, 2-oxo-l,3-benzoxazolyl, 2,3-dihydro-5H-l,3- thiazolo[3,2-a]pyrimidinyl, 5,6,7,8-tetrahydro-quinazolinyl, 4-oxochromanyl, 1,3- benzothiazolyl, benzimidazolyl, benzotriazolyl, purinyl, furylpyridyl, thiophenylpyrimidyl, thiophenylpyridyl, pyrrolylpiridyl, oxazolylpyridyl, thiazolylpiridyl, 3,4 dihydropyrimidin-1- yl imidazolylpiridyl, quinoliyl, isoquinolinyl, quinazolinyl, quinoxalinyl , naphthyridinyl, pyrazolyl[3.4]pyridine, 1,2 di hydroisoquinolinyl, cinnolinyl, 2,3dihydro-benzo[l,4]dioxin-6- yl, 4,5.6,7-tetrahydro-benzo[b]thiophenyl-2-yl, 1.8naphthyridinyl, l,6naphthyridinyl, 3,4 dihydro-2H-l,4-benzothiazine, 4,8-Dihydroxy-quinolinyl, l-oxo-l,2-dihydro-isoquinolinyl or 4-phenyl-[l,2,3]thiadiazolyl and the like. The term 5 or 6 membered heterocyclic group refers to 5 or 6 ring member containig at least one heteroatom selected from oxygen, sulphur or nitrogen, which may be saturated, unsaturated. Examples of such groups include piperidyl, 2-oxodihydrofuranyl, piperazinyl, morpholinyl, pyrazolidinyl, 1,2 dihydro-3H-pyrazolyl ,imidazolidinyl or pyrrolidinyl and the like. The term 9 to 10 membered fused bicyclic carbocyclic group refers to a 5,6/6,5 or 6,6 bicyclic carbocyclic ring system which may be saturated, unsaturated or aromatic. It also refers to a phenyl fused to one 5 or 6 membered saturated or unsaturated carbocyclic group. Examples of such groups include naphthyl, 1, 2, 3, 4 tetrahydronaphthyl, indenyl or indanyl and the like. The term optionally substituted phenyl, optionally substituted 5-6 membered heterocyclic group, optionally substituted 9 to 10 membered fused bicyclic carbocyclic group, optionally substituted 9 to 10 membered fused bicyclic heterocyclic group or optionally substituted 5 or 6 membered heteroaryl group this refers to a 5-6 membered heterocyclic, a 9 to 10 membered fused bicyclic carbocyclic, a 9 to 10 fused bicyclic heterocyclic or 5 or 6 membered heteroaryl as defined above which is substituted by 1 to 4 groups, which may be the same or different, selected from (CH2)pRιo grou wherein p is zero or an integer from 1 to 4 and Ri Q is selected from: halogen, Cι _4alkoxy, Chalky-, hydroxy, cyano, nitro, oxo, trifluoromethyl, carboxy, N 8 R 9 , COR 8j CONR 8 R 9 , NHCORg, NHS0 2 R 8 , S(0)qRg (wherein q is 0 or an integer from 1 to 2), phenyl (optionally substituted by halogen, C^alkoxy or -SrRgR 9 ); phenoxy; 5 -membered heteroaryl containing at least 1 heteroatoms selected from oxygen, sulphur or nitrogen and a 6-membered heteroaryl group containing at least 1 nitrogen atom which 5-6membered heteroaryl may be substituted by Cι_4alkyl or cyano. or 9 or 10 membered fused bicyclic heterocyclic . When R4 is an optionally substituted C3_ cycloalkyl, such a group is optionally substituted by 1 or 2 substituents which may be the same or different and selected from C1.4 alkyl, halogen, cyano, nitro, trifluoromethyl and NRgR7. When X is a Cι_ιo alkylene, a C2-I0 alkynylene or a C2-.10 alkenylene chain which is interrupted by a bivalent radical group selected from -O- , -NRg-, -C(O)-, -N(Rg)C(Y)N(R 9 )- , -S(0)m-, -N(R 8 )C(0)-, -C(0)N(Rg)-, N(R 8 )C(0)C(0)-, -C(0)0- or -C(NORg)-, this refers for example to Ci _IQ alkylene-O-, Ci øalkylene-NR C(N !N[R - S Ci o a ^l ene ~NT-*--8*- : , Ci . 10 alkylene-C(O)-, CJ.JQ alkylene-NR 8 C(0)-, C j - j o alkylene- C(0)ML 8 -, Cι_ιo alkylene-N(Rg)C(0)C(0)-, Cι_ιo alkylene-C(0)0-, Cι_ 10 alkylene c(NORg), c 2 .ιo alken y lene -°-' c 2 .ιo alken y lene - NR 8-> c 2- 10 alkenylene-NTlgC(Y)NR9-, C 2 _ιo alkenylene-S(0)m-, C2.10 alkenylene-NRgC(O)-, C 2 . 10 alkenylene-C(0)NRg-, C 2 .ιo alkenylene-N(R 8 )C(0)C(0)-, C _ιo alkenylene-C(0)0-, C2.10 alkenylene-C(NORg), C2_ιoalkynylene-NRg-, C2- ι θalkynylene-C(O)-, C 2 4oalkynylene-]SIΪtgC(Y)-\ER9-, C24oalkynylene-S(0)m-, C 2 -. lθalkynylene-NRgC(O)-, C2-10 alkynylene-C(0)NR 8 -, C240 a lkynylene-N( g)C(O)C(O)-, C 2 _ιo alkynylene-C(0)0-, C240 alkynylene-C(NORg), or this refers to a Ci .^Q alkylene, a C240 alkenylene or a C2-10 alkynylene chain containing a bivalent radical group selected from: -0-, -NR 8 -, -C(O)-, -NRgC(Y)NR 9 -, -S(0)m-, -NRgC(O)-, -C(0)NRg-. When A is -N(Rg)-, -N(Rg)S(0) 2 - or -N(Rg)C(Y)N(R 7 ) and when X is an optionally substituted C1 0 alkylene interrupted by a bivalent radical selected from -0-, -N(Rg)-, - N(Rg)C(Y)N(R 9 )-, -S(0)m-, -N(Rg)C(0)- or -N(Rg)C(0)C(0)- said bivalent radicals are preferably linked to A group by an optionally substituted alkylene chain containing at least two carbon atoms. When A is -N(Rg)-, -N(Rg)S(0) 2 - or -N(R 5 )C(Y)N(R 7 ) and when X is an optionally substituted C240 alkenylene or an optionally substituted C240 alkynylene chain and when these chains are interrupted by a bivalent radical selected from -0-, -N(Rg)-, - N(Rg)C(Y)N(R 9 )-, -S(0)m-, -N(R 8 )C(0)- or -N(R 8 )C(0)C(0)- said bivalent radicals are preferably linked to the A group by an optionally substituted alkenylene or alkynylene chain containing at least 4 carbon atoms and having -CH j- as terminal groups. A preferred group of compounds of formula (I) are those in which the carbon atom shown as 21 is in the β configuration. R is preferably (CH 2 ) n A-X-R 4 or (CH 2 ) n R5. Ri is preferably methyl or 2-propenyl. R2 is preferably hydrogen. R3 is preferably hydrogen or fluorine. When R4 is a 5 or 6 membered heteroaryl group this is preferably imidazolyl, imidazolyl, pyrazolyl, thiophenyl, 1,2,3-triazolyl, pyridinyl or furanyl. When R4 or R5 is a 5 or 6 membered heterocyclic group this is preferably imidazolidinyl or pyrrolidinyl. When R4 is a 9 or 10 membered fused bicyclic heteroaryl group this is preferably quinolinyl, quinoxalinyl, indolyl, purinyl, 1,3 benzo[l,3]dioxolyl, benzothiazolyl, lH-benzimidazol-yl 1,3-benzoxazoyl, lH-pyrrolo[2,3-b]pyridinyl , l,3-dihydro-2H-isoindolyl, 3H-imidazo[4,5- c]pyridin-3-yl, 3H-imidazo[4,5-b]pyridin-3-yl, 7H-purin-7-yl, lH-imidazo[4,5-c]pyridin-l-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl. R5 is preferably 1-pyrrolidinyl which is optionally substituted by one oxo or benzo [1,3 jdioxolyl. X is preferably a C\_ ζ alkylene, a C2.5 alkenylene or a C2.5 alkynylene chain wherein said chains are: i) optionally interrupted by a bivalent radical group selected from -0-, -N(R 8 )-, - C(O)-, -N(R 8 )C(Y)N(R 9 )-, -S(0)m-, -N(R 8 )C(0)-, -C(O)N(R 8 )-, -N(Rg)C(O)C(0)-, -C(0)O- or -C(NORg)-and/or ii) optionally substituted by one or two groups selected from: C1.4 alkyl, oxo, C1-4 alkoxy, halogen, cyano, phenoxy, hydroxy, N gR 9 , N(R 8 )C(0)R9, =NORg, NRgC(Y)-STR9 or optionally substituted phenyl. n is preferably 0 or 1. Preferred compounds of the invention are those wherein A is selected from -NH-, -NHC(O)- or -NHC(Y)NH-. Within this class the compounds in which n is 0 or 1 are particular preferred. A preferred class of compounds of formula (I) are those wherein X is a C1-.4 alkylene chain which is optionally interrupted by a bivalent radical selected from -0-, -NH-, -C(0)-, - NHC(0)-, -S(O)2- -S- and /or such a C1.4 alkylene chain is optionally substituted by one group selected from NH2, Cι _4 alkyl, oxo orN-OH. A particularly preferred group of compounds of formula (I) is that wherein R4 is phenyl (optionally substituted by 1 to 3 groups which may be the same or different selected from nitro, amino, methyl, Cj- alkoxy ie methoxy or hydroxy), 1 -imidazolyl (optionally substituted by 1 to 3 groups which may be the same or different selected from pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, phenyl, m-nitrophenyl, dichlorophenyl, C1.4 alkyl i.e methyl, trifluoromethylphenyl, thiophen-2-yl, thiazol-2-yl), 3-trifluoromethylpyrazol-4-yl, 1- pyrazolyl (optionally substituted by 1 to 3 groups which may be the same or different selected from alogen (i.e. chlorine, fluorine), pyridin-2-yl, pyridin-4-yl, quinolin-2-yl, quinolin-4-yl, quinoxalin-2-yl, pyrimidin-4-yl, C1.4 alkyl i.e methyl, 1,3 benzooxazol-2-yl, p-chloro phenyl, difluoro phenyl, pyrazin-2-yl thiazol-5-yl, lH-indol-3-yl, lH-indol-2-yl, 3-methoxy- quinoxalin-2-yl, 2-quinolinyl 3-quinolinyl, 4-quinolinyl, 4-pyridinyl, 3-pyridinyl(optionally substituted by one amino), 5methyl furan-2-yl, 3-thiophenyl, 6-methoxy-7H-purin-7-yl, quinoxalin-2-yl, 3 -methoxy quinoxalin-2-yl 6-methoxy-2-oxol, 3-benzoxazol-3(2H)-yl, 1H- pyrrolo[2,3-b]pyridin-l-yl, 2-(methylthio)-lH-benzimidazol-l-yl, l,3-dioxo-l,3-dihydro-2H- isoindol-2-yl, 6-methoxy-2-oxo-l ,3-benzoxazol-3(2H)-yl, 3H-imidazo[4,5-b]pyridin-3-yl, l,3-benzoxazol-2-yl, benzothiazol-2-yl, 1,3 benzo[l,3]dioxolyl, 3-(5-cyano-3,4- dimethylthien-2-yl)-lH-l,2,4-triazol-l-yl, 2,3-dihydro-benzo[l,4]dioxin-6-yl, 2,4-dimethyl- 1 ,3-thiazol-5-yl or 4-oxo-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl. A particularly preferred group of compounds of formula (I) are those wherein Ri is methyl, R2 or R3 is hydrogen, A is — H-, -NHC(O)-, X is Ci .4 alkylene chain which is optionally interrupted by a bivalent radical selected from -O-, -NH-, -C(0 , -NHC(0 , -S(0)2- -S- and /or such a Ci .4 alkylene chain is optionally substituted by one group selected from NH2, Ci _ 4 alkyl, oxo or N-OH, R4 is a group selected from 4-(pyridin-3-yl)-imidazol-l-yl, 4-(pyridin- 3-yl)-imidazol-l-yl, quinoxalin-2-yl, quinoxalin-2-yl, quinolin-4-yl, quinoxalin-2-yl, -(2,3- dihydro-benzo[l ,4]dioxin-6-yl, 4-oxo-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, 4-methoxy- 3-nitro-phenyl, 2-hydroxy-4,5-dimethoxy-phenyl, 3-hydroxy-4-methoxy-phenyl, 3,4- dimethoxy-phenyl, 4-hydroxy-3 -methoxy-phenyl, 3-methoxy-quinoxalin-2-yl, 3-amino-4- methoxy-phenyl, 4-(pyridin-3-yl)-imidazol-l-yl, quinolin-4-yl, 4-pyrimidin-4-yl-pyrazol-l- yl, 2-(methylthio)-lH-benzimidazol-l-yl, -[3-(4-chlorophenyl)-lH-pyrazol-5- yl]propylamino)-methylene], 6-methoxy-2-oxo-l,3-benzoxazol-3(2H)-yl, lH-pyrrolo[2,3- b]pyridin- 1 -yl, 3 -(2,4-dimethyl- 1 ,3 -thiazol-5 -yl)- lH-pyrazol- 1 -yl, 4-phenyl- 1 H-imidazol- 1 - yl, 4-pyridin-4-yl-l H-imidazol- 1-yl, thiophen-2-yl, 3-(5-cyano-3,4-dimethylthien-2-yl)-lH- 1,2,4-triazol-l-yl, quinolin-3-yl, l,3-thiazol-2-yl and n is 0 or 1. Particularly preferred compounds of the invention are selected from: (1 IS, 21R)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl-(4-(4- (pyridin-3-yl)-imidazol-l-yl)-butyramidomethyl)-methylene]-erythromycin A; (1 IS, 21R)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- (pyridin-3-yl)-imidazol-l-yl)-propionamidomethyl)-methylene]-erythromycin A; (1 lS,21R)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2- (quinoxalin-2-ylsulfanyl)-acetamidomethyl)-methylene]-erythromycin A; (1 lS,21R)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3- (quinoxalin-2-ylsulfanyl)-propionamidomethyl)-methylene]-erythromycin A; (1 lS,21R)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-[(quinolin- 4-ylmethyl)-amino]-methyl)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3- (quinolin-4-yl)-propionamido)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2- (quinoxalin-2-ylsulfanyl)-acetamido)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl-((4-(2,3- dihydro-benzo[l,4]dioxin-6-yl)-4-oxo)-butyramido)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl-(4-(4- oxo-4,5,6J-tefrahydro-benzo|^]thiophen-2-yl)-4-oxo-bu1yra_-mdo)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(4- methoxy-3-mtro-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(2- hydroxy-4,5-dimethoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl-(4-(3- hydroxy-4-methoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(3,4- dimethoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (HS, 21R,S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(4-(4- hydroxy-3-methoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2-(3- methoxy-quinoxalin-2-ylsulfanyl)-acetamido)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2- (quinoxalin-2-yloxy)-acetamido)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(3- amino-4-methoxy-phenyl)-4-oxo-butyramide)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4- hydroxymino-4-(4-methoxy-3-nitro-phenyl)-butyramide)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,11 -[oxycarbonyl-(2- (quinoxaline-2-sulfonyl)-acetamide)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- (pyridin-3-yl)-imidazol-l-yl)-propylamino)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2-(4- (pyridin-3-yl)-imidazol-l-yl)-ethylamino)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4- (quinolin-4-yl)-butylammo)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2- (quinolin-4-yl)-ethylamino)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- pyrimidin-4-yl-pyrazol-l-yl)-propylamino)-methylene]-erythromycin A; (HS,21R,S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(3-[2- (methylthio)-lH-benzimidazol-l-yl]propylamino)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-[3-(4- chlorophenyl)-lH-ρyrazol-5-yl]propylamino)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(6- methoxy-2-oxo-l,3-benzoxazol-3(2H)-yl)propylamino)-methylene]-erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(lH- pyrrolo[2,3 -b]pyridin- 1 -yl)proρylamino)-methylene] -erythromycin A; (1 lS,21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-[3- (2,4-dimethyl-l,3-thiazol-5-yl)-lH-pyrazol-l-yl]propylamino)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3- (quinoxalin-2-ylsulfanyl)-propylamino)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- phenyl- 1 H-imidazol- 1 -yl)propyl)amino)-methylene] -erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2-(4- pyridin-4-yl- 1 H-imidazol- 1 -yl)ethylamino)-methylene] -erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl-(2- (quinoxalin-2-ylsulfanyl)-ethylamino)-methylene] -erythromycin A; (11 S, 21 S)-3-decladinosyl-l 1, 12-dideoxy-6-0-methyl-3-oxo-12, 11 -[oxycarbonyl-(3-(4- (thiophen-2-yl)-imidazol-l-yl)-propylamino)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-((3-[3-(5- cyano-3 ,4-dimethylthien-2-yl)-lH- 1 ,2,4-triazol- 1 -yl]propyl)amino)-methylene]-erythromycin A; (US, 21R,S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-((3- quinolin-3 -ylpropyl)amino)-methylene]-erythromycin A; (HS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-((3-[4-(3- nitrophenyl)-lH-imidazol-l-yl]propyl)amino)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-((2-[3- (l,3-thiazol-2-yl)-lH-pyrazol-l-yl]ethyl)amino)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl-((2-(4- phenyl-lH-imidazol-l-yl)ethyl)amino)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-2-fluoro-6-0-methyl-3-oxo-12,l l-[oxycarbonyl- (2-(quinoxalin-2-ylsulfanyl)-acetamido)-methylene]-erythromycin A; (1 IS, 21R,S)-3-decladinosyl-l l,12-dideoxy-2-fluoro-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl- (3-(4-(pyridin-3-yl)-imidazol-l-yl)-propylarnino)-methylene]-erythromycin A. Further preferred compounds of the invention include: (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl-(2-(4- (pyridin-3 -yl)-imidazol- 1 -yl)-ethylamino)-methylene] -erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2- (quinolin-4-yl)-ethylamino)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- (pyridin-3 -yl)-imidazol- 1 -yl)-propylamino)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2- (quinoxalin-2-ylsulfanyl)-acetamido)-methylene]-erythromycin A; (1 IS, 21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-((4-(2,3- dihydro-benzo[l,4]dioxin-6-yl)-4-oxo)-butyramido)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(4- methoxy-3 -nitro-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(2- hydroxy-4,5-dimethoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(4-oxo- 4,5,6J-tefrahydro-benzo[b]thiophen-2-yl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- quinolin-2-yl- 1 H-pyrazol- 1 -yl)propylamino)-methylene] -erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(3,4- dimethoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; ( 11 S, 21 S)-3 -decladinosyl- 11,12-dideoxy-6-0-methyl-3 -oxo- 12, 11 -[oxycarbonyl-(4-(4- hydroxy-3-methoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 IS, 21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- (thiophen-2-yl)-imidazol-l-yl)-propylamino)-methylene]-erythromycin A. Compounds according to the invention also exhibit a broad spectrum of antibacterial activity against a wide range of clinical pathogenic microorganisms. For example, using a standard microtiter broth serial dilution test, compounds of the invention have been found to exhibit useful levels of activity against a wide range of pathogenic microorganisms including Staphylococcus aureus, Streptococcus pneumoniae, Moraxella catarrhalis, Streptococcus pyogenes, Haemophilus influenzae. Furthermore compounds of the invention are also active against intracellular pathogens such as Chlamydia pneumonia, Clamydia spp, Legionella pneumophila, Mycoplasma pneumonia, species. The compounds of the invention may therefore be used for treating a variety of diseases caused by pathogenic bacteria in human beings and animals. Thus, according to another aspect of the present invention, we provide a compound of formula (I) or a physiologically acceptable salt thereof for use in the therapy in a human or animal subject. According to a further aspect of the invention we provide the use of a compound of formula (I) or a physiologically acceptable salt thereof for the manufacture of a therapeutic agent for the treatment of systemic or topical bacterial infections in a human or animal body. According to a yet further aspect of the invention we provide a method of treatment of the human or non-human animal body to combat bacterial infections which method comprises administering to the body an effective amount of a compound of formula (I) or a physiologically acceptable salt thereof. The term treatment is also meant to include prophylaxis. While it is possible that, for use in therapy, a compound of the invention may be administered as the raw chemical, it is preferable to present the active ingredient as a pharmaceutical formulation. The compounds of the invention may be formulated for administration in any convenient way for use in human or veterinary medicine and the invention therefore includes within its scope pharmaceutical compositions comprising a compound of the invention adapted for use in human or veterinary medicine. Such compositions may be presented for use in conventional manner with the aid of one or more suitable carriers or excipients. The compositions of the invention include those in a form especially formulated for parenteral, oral, buccal, rectal, topical, implant, ophthalmic, nasal or genito-urinary use. The compounds according to the invention may be formulated for use in human or veterinary medicine by injection (e.g. by intravenous bolus injection or infusion or via intramuscular, subcutaneous or infrathecal routes) and may be presented in unit dose form, in ampoules, or other unit-dose containers, or in multi-dose containers, if necessary with an added preservative. The compositions for injection may be in the form of suspensions, solutions, or emulsions, in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilising, solubilising and/or dispersing agents. Alternatively the active ingredient may be in sterile powder form for reconstitution with a suitable vehicle, e.g. sterile, pyrogen-free water, before use. The compounds of the invention may also be presented for human or veterinary use in a form suitable for oral or buccal administration, for example in the form of solutions, gels, syrups, mouth washes or suspensions, or a dry powder for constitution with water or other suitable vehicle before use, optionally with flavouring and colouring agents. Solid compositions such as tablets, capsules, lozenges, pastilles, pills, boluses, powder, pastes, granules, bullets or premix preparations may also be used. Solid and liquid compositions for oral use may be prepared according to methods well known in the art. Such compositions may also contain one or more pharmaceutically acceptable carriers and excipients which may be in solid or liquid form. The compounds of the invention may also be administered orally in veterinary medicine in the form of a liquid drench such as a solution, suspension or dispersion of the active ingredient together with a pharmaceutically acceptable carrier or excipient. The compounds of the invention may also, for example, be formulated as suppositories, e.g. containing conventional suppository bases for use in human or veterinary medicine or as pessaries e.g. containing conventional pessary bases. The compounds according to the invention may be formulated for topical administration, for use in human and veterinary medicine, in the form of ointments, creams, gels, lotions, shampoos, powders, (including spray powders), pessaries, tampons, sprays, dips, aerosols, drops (e.g. eye ear or nose drops) or pour-ons. Aerosol sprays are conveniently delivered from pressurised packs, with the use of a suitable propellant, e.g. dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. For topical administration by inhalation the compounds according to the invention may be delivered for use in human or veterinary medicine via a nebuliser. The pharmaceutical compositions for topical administration may also contain other active ingredients such as corticosteroids or antifungals as appropriate. The compositions may contain from 0.01-99% of the active material. For topical administration, for example, the composition will generally contain from 0.01-10%, more preferably 0.01-1% of the active material. For systemic administration the daily dose as employed for adult human treatment it will range from 2-100mg/kg body weight, preferably 5-60 mg/kg body weight, which may be administered in 1 to 4 daily doses, for example, depending on the route of administration and the condition of the patient. When the composition comprises dosage units, each unit will preferably contain 200 mg to 1 g of active ingredient. The duration of treatment will be dictated by the rate of response rather than by arbitrary numbers of days . Compounds of general formula (I) and salts thereof may be prepared by general method outlined hereinafter. In the following description, the groups Ri, R2, R3, R4, R5, R , R7, Rδ, R9 , Rio, n, m, p, q, X, Y and A have the meaning defined for the compounds of formula (1) unless otherwise stated. Compounds of formula (I), wherein A is -N(Rg)C(0)- or a -N(Rg)S(θ2)-, may be prepared by reaction of compounds of formula (H) (H) (iπ) wherein Rj is a cladinose derivative of formula (III), in which R2 a is a hydroxy protecting group, or hydroxy, Ri 2 is hydrogen or Ri 2 together Ri j is an oxygen atom, with a suitable activated derivative of the acid (TV), HOC(0)XR4 (IV) or with a suitable activated derivative of the sulfonic acid (V) HOS(0)2XR4 (V) respectively and, if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3-hydroxy group into the 3-oxo; c) removal of the protecting group R2. Suitable activated derivatives of the carboxyl group or the sulphonic acid include the corrisponding acyl halide, mixed anhydride or activated ester such as a thioester or a pentafluoroester. The reaction is preferably carried out in a suitable aprotic solvent such as halohydrocarbon (e.g. dichloromethane) or N,N-dimethylformamide optionally in the presence of a tertiary base such as pyridine, dimethylaminopyridine or triethylamine and at a temperature within the range of 0° to 120°C. Compounds of formula (I) wherein A is -N(Rg)C(Y)N(R7)- and R7 is optionally substituted phenyl or C 1.4 alkyl, may be prepared from compounds of formula (II), wherein R14 and Rχ2 have the meaning defined above, by reaction with a compound of formula R4XNR7C(Y)L (VI), wherein L is a suitable leaving group as above defined and R7 is phenyl or C 1.4 alkyl, if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3- hydroxy group into the 3-oxo and c) removal of the protecting group R2. Compounds of formula (I) wherein A is -N(Rg)C(Y)NH- may be prepared from compounds of formula (IT) ), wherein R \ and R12 have the meaning defined above by reaction with a compounds of formula R4XN=C=Y (VII), if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (HI); b) conversion of the 3-hydroxy group into the 3-oxo and c) removal of the protecting group R2. Compounds of formula (I) wherein A is -N(Rg)- may be prepared from compounds of formula (H) ), wherein R14 and R12 have the meaning defined above, by reaction with a compounds of formula R4XL (VIII)-, wherein L is a suitable leaving group. If required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3-hydroxy group into the 3- oxo and c) removal of the protecting group R2. Suitable leaving groups for this reaction include halogen (e.g. chlorine, bromine or iodine) or sulfonyl (e.g. tosyl or methansulfonyl). Compounds of formula (I) wherein R is A is a N(Rg)C(0)0 group, in which Rg is hydrogen, phenyl or C1.4 alkyl, may be prepared from compounds of formula (II), wherein R \ and Ri 2 have the meaning defined above, by reaction with the appropriate haloformate compound of formula R4XOC(0)L (IX) wherein L is a suitable leaving group such as halogen (e.g. chlorine or bromine) and, if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (IS); b) conversion of the 3-hydroxy group into the 3-oxo and c) removal of the protecting group R2. The reactions of compounds (II) with compounds (VI), (VII), (VIII) or (IX) are conveniently carried out in a solvent such as tetrahydrofuran, acetonitrile or halohydrocarbon (e.g. dichloromethane) optionally in the presence of a base such as triethylamine and at a temperature within the range 0° to 80°C. Compounds of formula (ϊ) wherein A is a N=C(Rg) group, may be prepared from compounds of formula (IF), wherem R\ \ is hydroxy, Ri 2 is hydrogen or Ri \ together Ri 2 is an oxygen atom, by reaction with a compound of formula R4XCHO (X) and, if required, subjecting the resulting compound to one or more of the following operations a) conversion of the 3-hydroxy group into the 3-oxo and b) removal of the protecting group R2- The reaction is preferably carried out in a solvent such as a halohydrocarbon e.g. dichloromethane at a temperature within the range 0° to 50°C. Compounds of formula (I), wherein A is N[C(0)Rg] may be prepared by treating a compound of formula (XI) in which Ri 1 and R12 have the meaning as defined for compounds of formula (II), by acylation reaction with the activated carboxylic acid of formula(XIa) RgCOOH (Xla). (XI) and, if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3-hydroxy group into the 3-oxo and c) removal of the protecting group R2. The reaction is preferably carried out in the presence of a base such as a tertiary amine e.g. triethylamine or pyridine in a solvent such as a halohydrocarbon e.g. dichloromethane at a temperature within the range 0° to 50°C. Suitable activated derivatives of the carboxyl group or the sulphonic acid include the corrisponding acyl halide, mixed anhydride or activated ester such as a thioester or a pentafluoroester. Compounds of formula (I) in which R is hydrogen may be prepared by decarboxylation of a compound of formula (XH), wherein j and 12 have the meaning as defined for compounds of formula (II), followed, if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3-hydroxy group into the 3-oxo and c) removal of the protecting group R2* (xπ) The decarboxylation may be carried out in the presence of a lithium salt such as lithium chloride, preferably in an organic solvent such as dimethylsulphoxide. Compounds of formula (I), wherein R is cyano, may be prepared by cyclisation of chlorine derivatives (XI--T) wherein R1 1 and R12 have the meaning as defined for compounds of formula (II), (xm) with potassium cyanide and conveniently in the presence of a solvent such as a N-N dimethylformamide and, if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3-hydroxy group into the 3-oxo and c) removal of the protecting group R2. hi a preferred embodiment of the invention, compounds of formula (I) in which A is -N(Rg)- and X is C 4oalkylene interrupted by NR 8 -, -N(R 8 )C(Y)N(R 9 )-, -N(R 8 )C(0)- or - N(Rg)C(0)C(0)-, may be prepared by reaction of a compound of formula (XIV), pαv) wherein Xa is C240 a lkyl-N(R 8 ), Ru and R12 are defined as in formula (II), with compounds LXhR4(XV), in which L is a suitable leaving group, Xb is a group selected from C(Y)N(R 9 ), C(Y)N(R 9 )C 1 .galkylene, C(O), C(O)Cι _ 8 alkylene, C(0)C(0) or C(0)Cι _ 8 alkylene and, if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3-hydroxy group into the 3-oxo and c) removal of the protecting group 2- Compounds of formula (XIV) may be prepared from compounds of formula (11) by reductive N-alkylation with a compound of formula HC(0)C2_9alkyl N(Rg)(XVI). The reaction is conveniently carried in a protic solvent such as alcohol, i.e methanol, and in the presence of a suitable metal reducing agent such as sodium borohydride or sodium triacetoxyborohydride. Compounds of formula (I) in which n is 2 or 3 and wherein X is optionally substituted and/or optionally substituted C140 alkylene may be prepared from a phosphite of formula (XVII), wherein R 1 and Rχ2 have the meaning defined in formula (II) and Ri 3 is Ci .4 alkyl, by Wittig-Horner reaction with an aldehyde of formula (XVHI), followed by reduction of the corresponding double bond using hydrogen and a metal catalyst (e.g. palladium) and, if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3-hydroxy group into the 3- oxo and c) removal of the protecting group R2. The Wittig-Horner reaction is carried out in the presence of a suitable organic or inorganic base such as l,8-diazabicyclo[5.4.0]undec-7-ene or diisopropylethylamine in an aprotic solvent such as dichloromethane, preferably at a temperature ranging between -20° to +80°C. In the reactions described above cladinose derivatives of formula (IH) may be removed by treatment with an organic or inorganic acid. Example of a suitable inorganic acid is hydrochloride. The reaction is carried out in the presence of water or an organic solvent such tetrahydrofuran, dichloromethane or mixture thereof. In the reactions described above the conversion of the 3-hydroxy group into the 3-oxo may be performed by oxidation reaction using a modified Moffatt-Pfitzner procedure. Suitable oxidizing agent include N,N-Dimethylaminopropyl-3 -ethyl carbodiimide - dimethylsulfoxide. The reaction is suitably carried out in the presence of pyridiniumtrifluoro acetate in a chlorinated solvent such as methylene chloride at -10°C to 25°C. In a further embodiment, the oxidation may be carried out using Dess Martin periodinane reagent. Compounds of formula (I), wherein A is NRg and in which Rg is optionally substitued Ci _ 4alkyl, may be prepared by treating amino compounds of formula (11), wherein Rg is hydrogen, with an alkylating agent L-R6 (XIX) wherein L is a suitable leaving group in the presence of a base. Compounds of formula (II) wherein n is 0 may be prepared by intramolecular Michael reaction of compounds of formula (XX) wherein R14 is a suitable nitrogen protecting group, Ri 1 and R12 have the meaning defined in formula (II), in the presence of an organic base such as l,8-diazabicyclo[5.4.0]undec-7-ene. (XX) The reaction conveniently takes place in an aprotic polar solvent such as acetonitrile, dimethylformamide or an aqueous mixture thereof, followed by removal of the nitrogen protecting group Ri 4. Suitable nitrogen protecting group R14 for use in this reaction includes diarylmethylidene such as diphenylmethylidene. Compounds of formula (IF) wherein n is 1 may be prepared by reduction of a compound of formula (XXI) . wherein Ri 1 and Ri 2 have the meaning defined in formula (H). (XXI) The reduction may be carried out using conventional reducing agents known in the art for converting a nitrile group into an amino group. Thus for example the reaction may be carried out using hydrogen in the presence of Raney-Nickel as catalyst. The reaction is preferably carried out in an alcoholic solvent such as metyl, ethyl or isopropyl alcohol. Compounds of formula (XXI) may be prepared by cyclisation of chlorine derivatives (XXII) wherein Ri and Ri 2 have the meaning as defined for compounds of formula (11), (XXII) with potassium cyanide and conveniently in the presence of a solvent such as a N-N dimethylformamide, followed if required, subjecting the resulting compound to one or more of the following operations a) hydrolysis of the cladinose derivative (III); b) conversion of the 3-hydroxy group into the 3-oxo and c) removal of the protecting group R2. Compounds of formula (XVII) may be prepared by heating a compound of formula (XXIII) (xxm) in an aprotic solvent such as N,N dimethylformamide at a temperature ranging from 60° to 120°C in the presence of a base such as l,8-diazabicyclo[5.4.0]undec-7-ene. Compounds of formula (XXHI) may be prepared by reaction of chlorine derivatives of formula (XXII) with (R j -jO^phosphite. The reaction is carried out in a suitable aprotic solvent such as a hydrocarbon (i.e. toluene or xylene), N,N-dimethylformamide or by neat at a temperature within the range of 80° to 160°C. Compounds of formula P--XII) may be prepared by reacting the corresponding hydroxy derivatives (XXIV), (xxrv) wherein R 1 4 and R12 have the meaning defined in formula (II), with a suitable activated derivative of the acid HOCOCH 2 Cl(XXV). Thus for example the esterification may be carried out by reaction with anhydride (ClCH2CO)2θ (XXVI) in a suitable aprotic solvent such as a halohydrocarbon (e.g. dichloromethane) or N,N-dimethylformamide and in the presence of a tertiary base such as pyridine, dimethylaminopyridine or triethylamine and at a temperature within the range of 0°C tol20°C. Compounds of formula (XX) may be prepared by treating a compound of formula (XXH) with sodium azide, subjecting the resulting azido compound to the following operations: a) reduction by conventional means for reducing azido group to amino group and b) conversion of the group Η2 into the nitrogen protecting group N=Rι 4 wherein Ri 4 has the meaning defined above and, if required, by removal of the hydroxy protecting group R2. The reduction to amino group may be carried out, for example, in the presence of triphenylphosphine and water. In a further embodiment of the invention compounds of formula (XX) may be prepared by treating a compound of formula (XXII) with NH4OH in the presence of solvent a suitable solvent for this reaction is dimethylsulphoxide and water. Compounds of formula (XXIV), may be prepared by reacting 11,12-carbonate erythromycin A derivatives (XXVII), Ri 1 and R j 2 have the meaning defined in formula (IT), with a strong base such as 1,8 diazabicyclo [5.4.0]undec-7-ene. (XXVII) The elimination reaction may be carried out in an organic solvent such toluene, ethyl acetate, N,N dimethylformamide or a mixture thereof, conveniently with heating. Compounds of formula (XXVII), may be prepared from erythromycin A derivatives of formula (XXVIII), (XXVIII) by conversion of the 2'- hydroxy group into the corresponding hydroxy protected group and by conversion of the 11, 12 hydroxy into a carbonate group using friphosgene in a suitable solvent such as dicholorometane, in the presence of pyridine. Compounds of formula (XXVIII), may be prepared by alkylation of an oxime of formula (XXIX) (xxrx) wherein Ri 5 is oxime protecting group and R2 and R2 a are a hydroxyl protecting group, with a compound of formula L-Rχ (XXX) in which L is a suitable leaving group such as a halogen (e.g. chlorine, bromine or iodine) or a sulfonyl (e.g. tosyl, methanesulfonyl), in the presence of a base, followed by hydrolysis of cladinose derivative and conversion of the 3- hydroxy group into the 3-oxo. The reaction with compound (XXX) is preferably carried out in a solvent such as a halohydrocarbon (e.g. dichloromethane), an ether (e.g. tefrahydrofuran, dimethoxyethane), acetonitrile and the like. Examples of the bases which may be used include potassium hydroxide, cesium hydroxide, tetraalkylammonium hydroxyde, sodium hydride, potassium hydride and the like, followed by subsequent removal of oxime protecting group. A suitable oxime protecting goup is Ri 5, for example, 1- isopropoxycyclohex-1-yl. Oxime compounds (XXIX) may be prepared by reaction of a compound of formula (XXXI) wherein R2 and R2 a are hydrogen, using analogous methods to those described in USP 6110965. (XXXI) Compounds of formula (I) wherein R3 is halogen may be prepared from compounds of formula (I) in which R3 is hydrogen and R2 is hydroxy protecting group by reaction with a halogenating agent in the presence of an organic or inorganic base. Suitable halogenating agents include N-fluoro benzensulfonimide, SELECTFLUORTM for fluorination, pyridinium tribromide or cyanogen bromide for bromination or hexachloroethane for chlorination. A convenient base for the reaction is selected from sodium hydride, potassium hydride, sodium carbonate, potassium hexamethyldisilazide, lithium diisopropylamide or pyridine. The reaction is carried out in a solvent such as N,N dimethylformamide, tefrahydrofuran or N-methylpyrrolidone or a mixture thereof, conveniently at a temperature within the range - 78° to 60°C. Alternatively the halo group in position 2 of the macrolide ring may be introduced in an earlier step of the synthesis of compounds of formula (I). Thus, for example, it may be indroduced by treating a compound of formulas (II), (IX), (XII), (XV), (XVI), (XVII), (XVIII), (XIX), (XXII) ) or (XXIII) provided that Ri 1 together with R12 is an oxygen atom, using the method above described for obtaining compound (I) wherein R3 is a halo group. Compounds of formula(I) wherein R is (CH2) n R5 may be prepared by intramolecular cyclisation of a compound of formula (XXXH), (xxxπ) wherein L is suitable leaving group such halogen (i.e chlorine or bromine), X is C4.5 alkylene chain optionally substituted by one or two groups selected from oxo 9 or 10 membered fused bicyclic heterocyclic having at least one heteroatom selected from oxygen, sulphur or nitrogen. The reaction is suitable carried out in the presence of an inorganic base or an organic base. Alternatively compounds of formula (I) wherein R is (CH2) n R5 may be prepared by intramolecular reductive N-alkylation of a compound of formula (XXXHI) (XXXIII) wherein R^g is 9 to 10 membered fused heterocyclic groups, r is 3 or 4. This reaction was carried out conveniently carried in an aprotic solvent such as dichloroethane and in the presence of a suitable metal reducing agent such as sodium borohydride or sodium triacetoxyborohydride. Compounds of formulas (IV), (V), (VI), (VII), (VIII), (IX), (X), (XIa), (XIII), (XVI), (XVIIl), (XIX), (XXI) or (XXV) are known or commercially available compounds or they may be prepared using methods known in the art. The nitrogen protection reaction may be. carried out with an appropriate imine such as benzophenone imine in an aprotic solvent e.g. dichloromethane preferably at room temperature. Where it is desired to isolate a compound formula (I) as a salt thereof, for example a pharmaceutically acceptable salt, this may be achieved by reacting the compound of formula (I) in the form of the free base with an appropriate amount of suitable acid and in a suitable solvent such as an alcohol (e.g. ethanol or methanol), an ester (e.g. ethyl acetate) or an ether (e.g. diethyl ether or tefrahydrofuran). Pharmaceutically acceptable salts may also be prepared from other salts, including other pharmaceutically acceptable salts, of the compound of formula (I) using conventional methods. Suitable hydroxy protecting reagent are those described by T.W. Greene and P.G.M Wuts in Protective Groups in Organic Synthesis 2 nd ed., John Wiley & Son, Inc 1991, which is incorporating by reference. Examples of suitable hydroxy protecting reagents include acetic anhydride, benzoic anhydride or a trialkylsilyl chloride in a protic solvent. Examples of aprotic solvent are dichloromethane, NN-dimethylformamide, dimethylsulfoxide, tefrahydrofuran and the like. The hydroxyl protecting groups may be removed by well known standard procedures. For example when R2a is a trialkyllsilyl group, this may be removed by treatment with tetrabutylammonium fluoride and acetic acid or by reaction with fluoride ions source such as triethyl amine tris (hydrogen fluoride) or this process is conveniently carried out in a solvent such as tefrahydrofuran or acetonitrile. When R2 or R2a is alkanoyl (i.e acetyl or benzoyl) these may be removed by treatment with an alcohol (e.g. methanol or ethanol). In any of the formulae (I), (IT), (XT), (XIV), (XVII), (XXI), (XXXII) or (XXXπi) shown above when there is a an asymmetric carbon atom and no specific configuration is shown then the formula includes all possible configurations. Specific stereoisomers of the compounds of formula (I) as defined in formula la and lb essentially free of the other stereoisomers may be prepared using general processes described above strarting with the appropriate stereisomer of formula (II). The process described above for preparing the compounds of formula (II) will in general give a mixture of diastereoisomers . The individual stereoisomers of the compounds of formula (H) may be separated each other by conventional techniques such as fractional crystallisation or more particularly by column chromatography, using for example a silica column. In a preferred embodiment of the invention the individual stereoisomer of formula (la) wherem R is H j may be prepared by epimerisation reaction of a compound of formula(lb) or mixture of (la) and (lb) wherein R is NH2. The reaction is carried out in the presence of benzaldehyde and DBU, followed by hydrolysis of the imine derivative with inorganic acid such as hydrochloride. The reaction is suitable carried out in aprotic solvent such as for example toluene, N-N dimethylformamide. The assignment of the R or S configuration at the 21 -position have been made according to the rules of Cahn, higold and Prelog, Experientia 1956, 12, 81. When examples are obtained as a diastereoisomeric mixture of 21R and 21S, unless otherwise stated, the 1 H-NMR spectra refers to the 1 H-NMR spectra of the predominant diastereoisomer (i.e. 21 S). In the Intermediates and Examples unless otherwise stated: Proton Magnetic Resonance (*H-NMR) spectra were recorded at 500 MHz, chemical shifts are reported in ppm downfield (δ) from Mβ4Si, used as internal standard, and are assigned as singlets (s), doublets (d), doublets of doublets (dd), triplets (t), quartets (q) or multiplets (m). Mass spectra were acquired with a Hewlett Packard 1100 MSD system equipped with a binary pump (Agilent Technologies), operating in positive electrospray ionisation mode. LC/MS (Liquid Chromatography/Mass Spectroscopy) data were obtained by using a HP 1100 LC system (Agilent Technologies) equipped with a Sedex Evaporative Light Scattering Detector model 75 (Sedere) coupled with a Platform LCZ Mass Spectometer (Micromass) operating in positive electrospray ionisation mode. The chromatographic analysis conditions were: column Waters XTerra MS C18 (4.6 x 30mm, 2.5μm); flow rate 0.8ml/min; mobile phase: aqueous solution of NH OAc (lOmM, pH 6.8) (A) and acetonitrile (B). LC (Liquid Chromatography) purifications were performed with a Waters 600 semi- preparative system equipped with a binary pumping system and a Jasco-UV detector. The chromatographic analysis conditions were: column Supelcosil ABZ+Plus (10cm x 21.2mm, 5μm); flow rate 8ml/min; mobile phase: aqueous solution of NH 4 OAc (lOmM, pH 6.8) (A) and acetonitrile (B). Column chromathography was carried out over silica gel 60 (230-400 mesh ASTM - Merck AG Darmstaadt, Germany). The TLC (Thin Layer Chromatography) monitoring was performed using Merck 60 F 2 s 4 as TLC plate. Phase separations were done by using Microfiltration Device - Filter Tube with polypropylene support (Whatman). Resin washings were carried out on Extract-clean Tube (Alltech). Purifications of crude products were performed by SCX-cartridges (Varian). PS-Trisamina resin (polystyrene based) (Argonaut Technologies Inc.) was used to remove the excess of reagents. Abbreviations which have been used in the description of the synthetic methods that follow are: Brine for aqueous saturated solution of sodium chloride, DBU 1,8- diazabicyclo[5.4.0]undec-7-ene, DCE for 1,2-dichloroethane, DCM for dichloromethane, DIPEA for N,N-diisopropylethylamine, DMAP for 4-dimethylaminopyridine, DMF for N,N- dimethylformamide, DMSO for methyl sulfoxide, EDC for l-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride, Et 2 0 for diethyl ether, EtOAc for ethyl acetate, HATU for 0-(7-azabenzotriazol-l-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, HOBT for 1-hydroxybenzotriazole hydrate, iPrOH for 2-propanol, MeOH for methanol, MTBE for tert- butyl methyl ether, TEA for triethylamine and THF for tefrahydrofuran, wt for weight. Intermediate 1 2'-O-Acetyl-ll,12-carbonate-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- erythromycin A To a solution of 2'-0-acetyl-3-decladinosyl-6-O-methyl-3-oxo-erythromycin A (0.500g) in anhydrous DCM (20mL) under nitrogen atmosphere, pyridine (1.5mL) and phosgene (20% sol. in toluene, lmL) were sequentially added. The reaction mixture was stirred overnight at room temperature then quenched with a saturated NaHC0 3 aqueous solution (50mL). The organic phase was washed with water (50mL), dried over Na 2 S0 4 , concentrated under reduced pressure and the crude product purified by flash chromatography (eluting with: DCM\MeOH 90\10) to give the title compound (0.360g). TLC: DCM\MeOH 90\10 (Rf=0.6). Intermediate 2 2'-O-Acetyl-3-decladinosyl-ll-deoxy-10,ll-didehvdro-6-O-methyl-3-oxo-ervthromycin A To a solution of intermediate 1 (0.210g) in 2\1 mixture of EtOAc\toluene (6mL), DBU (0.05mL) was added and the mixture was heated to 85°C for 6h. The reaction mixture was allowed to reach room temperature, the solvent evaporated and the crude product purified by flash chromatography (eluting with: DCMXMeOH 90\10) to give the title compound (0.150g). TLC: DCM\MeOH 90 .10 (Rf=0.7). Intermediate 3 2'-O-Acetyl-12-chloroethanoyI-3-decIadinosyI-ll-deoxy-10,ll-didehvdro-6-O-methyl-3- oxo-ervthromycin A To a solution of intermediate 2 (0.150g) in anhydrous DCM (3mL) cooled to 0°C, pyridine (0.05mL), chloroacetic anhydride (0.065g) and DMAP (5mg) were sequentially added under nitrogen atmosphere. The reaction mixture was stirred for 4h then quenched with water (lOmL) and extracted with DCM (2xl0mL). The organic phase was dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCM \MeOH 80\20) to give the title compound (0.060g). TLC: DCM\MeOH 90\10 (R =0.8). Intermediate 4 (ll-_- , .21i?)-2 , -O-Acetyl-3-decIadinosyl-lia2-dideoxy-6-0-methyl-3-oxo-12ai- [oxycarbonyl-(iminomethyl)-methylenel -erythromycin A To a solution of example 1 (0.137g) in iPrOH (20mL) Raney-Nickel (O.lOOg) was added. The reaction mixture was saturated with hydrogen (5atm) and stirred at room temperature for 24h. After removing the catalyst by filtration and evaporating the solvent under reduced pressure, the crude material was purified by flash chromatography (eluting with: DCM VIeOH 95 .5) to give the title compound (0.012g). iH- MR (CDC1 3 ) δ: 7.61, 7.07 (t+t, IH), 4.94, 4.82 (dd+dd, IH), 4.76 (m, IH), 4.39, 4.38 (d+d, IH), 4.24, 4.22 (d+d, IH), 3.83 (q, IH), 3.55 (m, IH), 3.26 (m, IH), 3.13 (m, IH), 3.02, 2.90 (d+d, IH), 2.96 (m, IH), 2.70 (m, IH), 2.65, 2.64 (s+s, 3H), 2.60, 2.50 (m+m, IH), 2.26 (s, 6H), 2.07, 2.06 (s+s, 3H), 1.94 (m, IH), 1.77-1.64 (m, 2H), 1.55 (m, IH), 1.50, 1.46 (s+s, 3H), 1.33 (d+d, 6H), 1.32 (s, 3H), 1.21 (d, 3H), 1.17 (m, IH), 1.14 (s, 3H), 0.97, 0.96 (d+d, 6H), 0.83, 0.80 (t+t, 3H). TLC: DCMVMeOH 95\5 (Rf= 0.65). Intermediate 5 (H-y.21ig)-3-DecIadinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl- (iminomethylVmethylenel -erythromycin A A solution of intermediate 4 (O.OlOg) in MeOH (ImL) was stirred for 48h, then concenfrated under reduced pressure to give the title compound (0.009g). iH-NMR (CDCI3) δ: 7.61, 7.09 (t+t, IH), 4.94, 4.83 (dd +dd, IH), 4.86 (bm, IH), 4.32, 4.30 (d+d, IH), 4.26, 4.24 (d+d, IH), 3.86 (m, IH), 3.56 (m, IH), 3.13-3.10, 2.96 (m, 3H) 3.02 (m, IH), 2.88 (bs, IH), 2.66 (s, 3H), 2.50 (m, IH), 2.30 (s, 6H), 1.95 (m, IH), 1.85, 1.76 (m, IH), 1.70-1.60 (m, 2H), 1.55 (m, IH), 1.49, 1.46 (s+s, 3H), 1.4-1.3 (m, 6H), 1.30-1.14 (m, 2H), 1.0-0.9 (d, 3H), 0.84, 0.81 (t+t, 3H). TLC: DCM\MeOH 95.5 (Rf= 0.45). Intermediate 6 2 ' ,4"-O-Diacetyl-6-O-methyl-ervtrhromycin A To a solution of 6-O-methyl-erytrhromycin A (50g) in anhydrous DCM (240mL), TEA (26. ImL), DMAP (0.392g) and acetic anhydride (15.2mL) were added at 0°C under nitrogen atmosphere. The resulting mixture was stirred at 0°C for 45min and overnight at room temperature. The mixture was then diluted with a saturated NH 4 C1 aqueous solution (240mL) and extracted with DCM (2x200mL). The aqueous phase was neutralised with a saturated NaHC0 3 aqueous solution and extracted again with DCM (2x200mL). The combined organic layers were dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (50.7g). m\z ([MH] + ) = 832. Intermediate 7 ll,12-Carbonate-2%4"-O-diacetyl-ll,12-dideoxy-6-O-methyl-ervtrhromvcin A To a solution of intermediate 6 (200g) in anhydrous DCM (1600mL) cooled to 0°C, pyridine (117mL) and a solution of friphosgene (71.2g) in anhydrous DCM (400mL) were added under nitrogen atmosphere. The resulting mixture was stirred at 0°C for 30min and then at room temperature for 15h. The mixture was then diluted with water (750mL) and extracted with DCM (2x500mL). The organic layer was washed with water (3x300mL), dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (200 g . m\z ([MH] + ) = 858. Intermediate 8 ll-Deoxy-2',4"-O-diacetyl-10,ll-didehydro-6-O-methyl-erytrhromvcin A To a solution of intermediate 7 (50.5g) in a 2\1 mixture of toluene EtOAc (675mL), DBU (12mL) was added at room temperature. The resulting mixture was stirred at 85°C for 8h and at room temperature for 5h. The reaction mixture was then diluted with brine (250mL), extracted with EtOAc (2x350mL) and dried over Na 2 S0 . The solvent was evaporated under reduced pressure and the crude material purified by crystallisation (from acetone\water) to give the title compound (46g). m\z ([MH] + ) = 814. Intermediate 9 12-ChIoroethanoyl-ll-deoxy-2 , ,4"-O-diacetyI-10,ll-didehydro-6-O-methyl- ervthromvcin A To a solution of intermediate 8 (20g) in anhydrous DCM (340mL) cooled to 0°C pyridine (6mL) and chloroacetic anhydride (8.4g) were added under nifrogen atmosphere and the reaction was allowed to reach room temperature. After 16h the reaction mixture was washed with water (300mL), a saturated NH 4 C1 aqueous solution (150mL) and brine (150mL) then extracted with DCM (2x300mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was dissolved in acetone (50mL) and water (lOOmL) was added under vigorous stirring. The precipitate was filtered and dried in vacuo to give the title compound (20.4g). m\z ([MH] + ) = 890. Intermediate 10 2'-O-Acetyl-12-chIoroethanoyl-3-decIadinosyl-ll-deoxy-10,ll-didehydro-6-O-methyl- erythromycin A To a solution of intermediate 9 (20.2g) in THF (200mL) cooled to 0°C a 3N HC1 aqueous solution (400mL) was added dropwise. The reaction mixture was allowed to reach room temperature and stirred overnight. The solution was neutralised with a saturated NaHC0 3 aqueous solution and extracted with DCM (2x200mL). The organic layer was dried over Na 2 S0 , concentrated under reduced pressure and the crude material purified by quick filtration on silica gel (eluting with: DCM\MeOH 95 .5) to give the title compound (15.4g). m\z ([MH] + ) = 690. Intermediate 11 (llS.21R)-2 , -O-Acetyl-3-decladinosyl-llJ2-dideoxy-6-O-methyl-12qi-foxycarbonyl- (cyano)-methylenel-ervthromycin A To a solution of intermediate 10 (0.400g) in anhydrous DMF (30mL) potassium cyanide (0.380g) was added under nitrogen atmosphere. The mixture was stirred at room temperature for 2h, quenched with a saturated NaHC0 3 aqueous solution (50mL) and extracted with DCM (70mL). The organic phase was dried over Na 2 S0 , concentrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCM\MeOH 90\10) to give the title compound (0.43 Og) . TLC: DCM\MeOH 90M0 (Rf=0.50). Intermediate 12 fllS.21i- -2 , -O-Acetyl-3-decladinosyl-ll,12-dideoxy-6-O-methyl-12,ll-roxycarbonyl- (iminomethv-Vmethylenel -erythromycin A and Intermediate 13 (llS.21R)-2 , -O-Acetyl-3-decladinosyl-ll,12-dideoxy- 6-O-methyl-12,ll-roxycarbonyl- (aminomethvD- ethylenel -erythromycin A To a solution of intermediate 11 (O.lOOg) in iPrOH (lOmL) Raney-Nickel (O.lOOg) was added. The mixture was saturated with hydrogen (5atm) and stirred at room temperature for 24h. After removing the catalyst by filtration and evaporating the solvent, the crude product was purified by flash chromatography (eluting with: DCMVMeOH 90\10) to give the title compound 12 (0.038g) and the title compound 13 (0.027g). TLC: DCMVMeOH 90\10, Rf (intermediate 12) =0.43 TLC: DCMXMeOH 90\10, Rf (intermediate 13) =0.2 Intermediate 14 (llS.21-R)-2 , -0-Acetyl-3-decladinosyl-ll,12-dideoxy-6-O-methyI-12.11-foxycarbonyl- (chloroacetamidomethyl)-methylenel -erythromycin A To a solution of intermediate 13 (0.054g) in anhydrous DCM (2mL) pyridine (O.OlOmL), chloroacetic anhydride (0.016g) and DMAP (catalytic amount) were sequentially added under nitrogen atmosphere. The mixture was stirred at 0°C for lh. The reaction was quenched with a saturated NaHCO 3 aqueous solution (5mL) and extracted with DCM (lOmL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 98V2) to give the title compound (0.036g). TLC: DCMVMeOH 90V10 (Rf=0.43). Intermediate 15 (ll-->,21-R)-2 , -O-Acetyl-3-decladinosvI-ll,12-dideoxy-6-O-methyl-12,ll-[oxycarbonyl- (chlorobutytr amidom ethylVmethylenel -erythromycin A To a solution of intermediate 13 (O.lOOg) in anhydrous DCM (4mL) pyridine (0.024mL), 4- chlorobutyryl chloride (0.016mL) and DMAP (catalytic amount) were sequentially added under nitrogen atmosphere. The mixture was stirred at 0°C for 2h. The reaction was quenched with a saturated NaHC0 3 aqueous solution (lOmL) and extracted with DCM (20mL). The organic phase was dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (O.lOOg). TLC: DCMVMeOH 90V10 (Rf=0.40). mVz ([MH] + ) = 789. Intermediate 16 2 , -O-Acetyl-12-aminoethanoyl-3-decladinosyl-ll-deoxy-10,ll-didehvdro-6-O-methyl- erythromycin A To a solution of intermediate 10 (3g) in DMSO (40mL) a 32% aqueous ammonia solution (8mL) was added dropwise over lOmin at room temperature. The reaction mixture was stirred for 2h at 50°C. After cooling to 0°C, water (40mL) was added and the mixture was extracted with MTBE (2x45mL). The collected organic layers were washed with brine (40mL), dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (2.5g). TLC: DCM VMeOH 10V1 (Rf=0.28). Intermediate 17 2'-O-Acetyl-12-(benzhydrylidene -aminoethanoyl-3-decladinosyl-ll-deoxy-10,ll- didehvdro-6-O-methyl-erythromvcin A A solution of intermediate 16 (4.0g) and benzophenone imine (2.6mL) in anhydrous DCM (40mL) was stirred at room temperature under nitrogen atmosphere. After 36h the reaction was quenched with water (lOOmL) and extracted with DCM (3x300mL). The organic layer was dried over Na 2 S0 , concentrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (3.5g). TLC: DCMVMeOH 10V1 (Rf=0.38). Intermediate 18 (llS,21R,-S l )-2 , -O-Acetyl-3-decladinosyl-ll,12-dideoxy-6-O-methyl-12,ll-[oxycarbonyl- (benzhvdrylideneamino)-methylenel-erythromvcin A A solution of intermediate 17 (3.0g) and DBU (0.540mL) in acetonitrile (135mL) and water (15mL) was stirred at room temperature for 3h. After evaporating the solvent, the crude material was dissolved in DCM (300mL) and washed with water (lOOmL). The organic layer was dried over Na 2 S0 and concentrated under reduced pressure to give the title compound (3.0g). TLC: DC VMeOH 10V1 (Rf=0.38). Intermediate 19 ll-Deoxy-2 , ,4"-O-diacetyl-10Jl-didehvdro-12-methoxycarbonylethanoyl-6-O-methyl- ervthromvcin A To a solution of intermediate 8 (0.500g) in anhydrous toluene (lOOmL) under nitrogen atmosphere, pyridine (0.250mL) and methylmalonyl chloride (0.158mL) were added at 0°C. The temperature was allowed to reach room temperature. After stirring for lh, water (50mL) was added, the organic layer was washed with brine (50mL) and dried over Na 2 S0 . The solvent was evaporated under reduced pressure and the crude material purified by quick filtration on silica gel to give the title compound (0.560g). mVz ([MH] + ) = 914. Intermediate 20 2 , -O-Acetyl-3-decladinosyl-ll-deoxy-10,ll-didehydro-12-methoxycarbonylethanoyl-6- O-methyl-erythromvcin A and Intermediate 21 2'-O-Acetyl-3-decladinosyl-ll-deoxy-10,ll-didehvdro-12-carboxyethanoyI-6-O-methyl- erythromvcin A A solution of intermediate 19 (0.500g) in a 2N HC1 aqueous solution (50mL) and THF (ImL) was stirred at room temperature for 6h. Then, the mixture was cooled to 0°C and a saturated potassium carbonate aqueous solution was added until pH= 9 was obtained. The mixture was exfracted with DCM (2x50mL), the organic phase washed with brine (25mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH = 95V5) to give the title compound 20 (0.180g), and the title compound 21 (0.180g). mVz ([MH] + ) (intermediate 20) = 714. mVz ([MH] + ) (intermediate 21) = 700. Intermediate 22 -ri0R.-y.ll .21R.-y)-2 , -O-Acetyl-3-decladinosyl-liα2-dideoxy-6-O-methyl-12,ll- foxycarbonyl-(methoxycarbonyl)-methylenel-erythromvcin A A solution of intermediate 20 (0.150g) and DBU (0.050mL) in water (1.5mL) and acetonitrile (13.5mL) was stirred at 40°C for 6h. After evaporating the solvent under reduced pressure, the residue was dissolved in DCM (20mL), the organic phase washed with water (50mL), dried over Na 2 S0 4 and concentrated under reduce pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.070g). mVz ([MH] + ) = 714. Intermediate 23 (10Jg.-y.llR)-2 , -O-Acetyl-3-decladinosyl-liα2-dideoxy-6-O-methγl-12.11- [oxycarbonylmethylenel-ervthromycin A A mixture of intermediate 22 (0.050g) and lithium chloride (0.006g) in DMF (ImL) was heated to reflux for 4h. The mixture was allowed to reach room temperature and poured into a 3% NaHC0 3 aqueous solution at 0°C, then extracted with DCM (2x15mL). The organic phase was washed with water (2x1 OmL), dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was vpurified by flash chromatography (DCMVMeOH: 95V5) to give the title compound (O.OlOg). mVz ([MH] + ) = 656. Intermediate 24 fllS.21S)-2 , -O-Acetyl-3-decladinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12αi- [oxycarbonyl-(2-(chloro -ethvIamino)-methylenel-ervthromycin A To a solution of example 7 (0.335g) in anhydrous acetonitrile (3mL) chloroacetaldehyde (50 wt % solution in water, 0.127mL) was added under a nitrogen atmosphere and the resulting mixture was stirred for 20h at room temperature. Sodium cyanoborohydride (IM in THF, 0.500mL) and acetic acid (0.041mL) were added and the reaction mixture was stirred for 6h at room temperature. After evaporating the solvent the residue was dissolved in DCM (25mL) and washed with a 5% NaHC0 3 aqueous solution (lOmL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure to give the title compound (0.300g). mVz ([MH] + ) = 731. Intermediate 25 (llS.21-R)-2 , -O-Acetyl-3-decladinosyl-liα2-dideoxy-6-O-methyl-12.11-roxycarbonyl-f3- quinoLtnyl-carbonvIaminomethvD-methvienel-erythromycin A To a solution of intermediate 13 (0.028g) in anhydrous DMF (2.5mL) 3-quinolinecarboxylic acid (0.008g), HATU (0.017g) and DIPEA (0.017mL) were sequentially added under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 4h and then the solvent evaporated under vacuum. The residue was dissolved in DCM (15mL) and washed with water (lOmL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure. The crude product was purified by flash chromatography to give the title compound (0.022g). TLC: DCMVMeOH 90V10 (Rf=0.37). Intermediate 26 fllS.21-R)-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-methyl-12.11-roxycarbonyl-(4- (4-(pyridin-3-yl)-imidazol-l-yl)-butyramidomethvI)-methylenel-ervthromycin A To a solution of intermediate 13 (0.050g) in anhydrous DMF (5mL) intermediate 49 (0.019g), HATU (0.030g) and DIPEA (0.03 ImL) were sequentially added under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 3h, and then the solvent was removed under vacuum. The residue was dissolved in DCM (20mL), the organic phase washed with water (15mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography to give the title compound (0.042g). TLC: DCMVMeOH 90V10 (Rf=0.37). Intermediate 27 fllS.21R)-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-methyl-12.11-roxycarbonyl-(3- (4-(pyridin-3-vI)-imidazol-l-yl)-propionamidomethyl)-methylenel-ervthromvcin A To a solution of intermediate 13 (0.050g) in anhydrous DMF (5mL) intermediate 48 (0.020g), HATU (0.030g) and DIPEA (0.03 ImL) were sequentially added under nifrogen atmosphere. The reaction mixture was stirred at room temperature for 4h and then the solvent was removed under vacuum. The residue was dissolved in DCM (15mL), the organic phase washed with water (lOmL), dried over Na 2 S0 4 and concentrated under reduced pressure. The crude product was purified by flash chromatography to give the title compound (0.042g). TLC: DCMVMeOH 90V10 (Rf=0.28). Intermediate 28 fll-S'.21--?)-2'-O-AcetvI-3-decladinosyI-ll,12-dideoxy-6-0-methyl-12.11-foxycarbonyl-(2- (4-(pyridin-3-vπ-imidazol-l-yl)acetamidomethyl)-methylenel-ervthromycin A To a solution of 3-(lH-imidazol-4-yl)-pyridine (0.005g) in anhydrous DMF (2mL) cooled to 0°C sodium hydride (O.OOlg) was added under nitrogen atmosphere. The reaction mixture was stirred at 0°C for lh then a solution of intermediate 14 (0.030g) in anhydrous DMF (ImL) was added. After 16h at room temperature the reaction was quenched with water (5mL) and the mixture extracted with DCM (lOmL). The organic phase was dried over Na 2 S0 , concentrated under reduced pressure and the crude material purified by preparative TLC (eluting with: DCMVMeOH 90V10) to give the title compound (0.020g). TLC: DCMVMeOH 90V10 (Rf=0.35). Intermediate 29 (ll-S l .21R)-2 , -O-Acetyl-3-decladinosyl-ll,12-dideoxy-6-O-methyl-12Jl-foxycarbonyl-(l- (pyrrolidin-2-one -methyl -methyIenel-ervthromvcin A To a solution of intermediate 15 (0.095g) in anhydrous DMF (8mL) cooled to 0°C, sodium hydride (0.004g) was added under nifrogen atmosphere. The mixture was stirred at 0°C for lh and at room temperature for 18h. Water (5mL) was added and exfracted with a mixture Et 2 OVDCM 80\20 (3xl0mL). The organic phase was dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH 90V10) to give the title compound (0.050g). mVz ([MH] + ) = 753. Intermediate 30 (ll-y.21R -2 , -O-Acetyl-3-decladinosyl-ll,12-dideoxy-6-0-methyl-12,ll-roxycarbonyl-(2- (quinoxalin-2-ylsuIfanyl)-acetamidomethyl)-methviene1-ervthromycin A To a solution of intermediate 13 (0.075g) in anhydrous DMF (7mL) (quinoxalin-2- ylsulfanyl)-acetic acid (0.029g), HATU (0.046g) and DIPEA (0.030mL) were sequentially added under nitrogen atmosphere. The mixture was stirred at room temperature for 6h. The solvent was evaporated under reduced pressure and the residue dissolved in DCM (20mL). The organic phase was washed with a saturated NaHC0 3 aqueous solution (2x15mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 90V10) to give the title compound (0.069g). mVz ([MH] + ) = 887. Intermediate 31 (H.S , .2lJ- -2 , -O-Acetyl-3-decladinosyl-liα2-dideoxy-6-O-methyl-12,ll-roxycarbonyl-(3- (quinoxalin-2-ylsulfanyl)-propionamidomethyl)-methylenel-ervthromycin A To a solution of intermediate 13 (0.030g) in anhydrous DMF (3mL) 3-(quinoxalin-2- ylsulfanyl)-propionic acid (0.012g), HATU (0.018g) and DIPEA (0.012mL) were sequentially added under nifrogen atmosphere. The mixture was stirred at room temperature for 6h then the solvent was evaporated under reduced pressure. The residue was dissolved in DCM (15mL), the organic phase washed with a saturated NaHC0 3 aqueous solution (2xl0mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 90V10) to give the title compound (0.035g). mVz ([MH] + ) = 901. Intermediate 32 (11^21i?)-2 , -0-AcetvI-3-decIadinosyl-ll,12-dideoxy-6-O-methyl-12Jl-foxycarbonvI- r(quinolin-4-ylmethylene)-aminol-methyl)-methvIenel-ervthromvcin A A solution of intermediate 13 (0.090g) and quinoline-4-carbaldehyde (0.023g) in anhydrous toluene (5mL) was heated at 50°C for 8h under nitrogen atmosphere. Solvent evaporation under reduced pressure gave the title compound (O.lOOg). mVz ([MH] + ) = 824. Intermediate 33 2 ' ,4"-O-Diacetyl-6-O-allyl-ervtrhromycin To a solution of 6-OAllyl erythromycin A (lg) in anhydrous DCM (5mL) cooled to 0°C, TEA (0.5mL), DMAP (0.008g) and acetic anhydride (0.3 ImL) were added under nitrogen atmosphere. The resulting mixture was stirred at 0°C for lh and overnight at room temperature. Then a saturated NH 4 C1 aqueous solution (3 OmL) was added the mixture exfracted with DCM (2x5 OmL). The aqueous phase was neutralised with a saturated NaHC0 3 aqueous solution and extracted again with DCM (2x50mL). The combined organic layers were dried over Na 2 S0 and evaporated under reduced pressure to give the title compound (lg). mVz ([MH] + ) = 858. Intermediate 34 ll,12-Carbonate-2 > ,4' : '-O-diacetvI-ll,12-dideoxy-6-0-aHyl-ervtrhromvcin To a solution of intermediate 33 (4.13g) in anhydrous DCM (85mL), pyridine (0.8mL) and then phosgene (20% sol in toluene, 2.55mL) were added at 0°C under nitrogen atmosphere. The resulting mixture was stirred at 0°C for 30min and then at room temperature for lh. The reaction mixture was then diluted with water (150mL) and extracted with DCM (2x200mL). The organic layer was washed with water (3xl00mL), dried over Na 2 S0 and evaporated under reduced pressure to give the title compound (4.02g). mVz ([MH] + ) = 884. Intermediate 35 ll-Deoxy-2',4"-O-diacetvI-10,ll-didehvdro-6-O-aIlyl-ervtrhromvcin To a solution of intermediate 34 (4.02g) in toluene (45mL) and EtOAc (23----L), DBU (0.71mL) was added at room temperature. The resulting mixture was heated to 85°C for 6h. The mixture was then diluted with brine (lOOmL), extracted with EtOAc (2x200mL) and dried over Na 2 S0 4 . Solvent evaporation under reduced pressure and purification by flash chromatography of the crude material (eluting with: DCMVMeOHVNH 4 OH 95V4V0.01) gave the title compound (1.70g). mVz ([MH] + ) = 840. Intermediate 36 12-Chloroethanoyl-ll-deoxy-2 , ,4"-O-diacetyl-10.,ll-didehvdro-6-O-aIlvI-ervthromvcip A To a solution of intermediate 35 (1.7g) in anhydrous DCM (50mL) cooled at 0°C, pyridine (0.66mL), DMAP (0.012g) and chloroacetic anhydride (0.695g) were added under nitrogen atmosphere. The resulting mixture was stirred for 30min at 0°C and then at room temperature for 2.5h. The mixture was diluted with water (50mL), neutralised with a saturated aqueous solution of NaHC0 3 and extracted with DCM (2xl00mL). The organic phase was washed with water (3x75mL), dried over Na 2 S0 4 and evaporated under reduced pressure to give the title compound (1.8g). mVz ([MH] + ) = 916. Intermediate 37 2 , -O-Acetyl-12-chIoroethanoyl-3-decladinosyl-ll-deoxy-10,ll-didehydro-6-O-allyl- erythromvcin A To a solution of intermediate 36 (1.8g) in THF (35mL), a 6N HCl aqueous solution (lOmL) was added at 0°C. The resulting mixture was stirred overnight at room temperature, then it was diluted with water (50mL). The pH of the solution was brought to 8-9 by addition of solid NaHC0 3 and a 1% NaOH aqueous solution, then the aqueous phase was extracted with DCM (2xl00mL). Solvent evaporation under reduced pressure and treatment of the residue with Et 2 0 gave the title compound (1.4g). m\z ([MH] + ) = 716. Intermediate 38 (llS.21R -2 , -O-Acetyl-3-decladinosyl-llJ2-dideoxy-6-O-alIyl-12,ll-roxycarbonyl- (cyano)-methylenel -erythromycin A To a solution of intermediate 37 (1.3g) in anhydrous DMF (40mL) potassium cyanide (0.500g) was added under nitrogen atmosphere. The reaction mixture was stirred at room temperature for lh, quenched with a 5% NaHC0 3 aqueous solution (50mL) and extracted with DCM (2x50mL). The crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH 95V4V0.01) to give the title compound (0.42g). mVz ([MH] + ) = 707. Intermediate 39 2'-O-Acetyl-12-azidoethanoyl-3-decladinosyl-ll-deoxy-10,ll-didehydro-6-O-allyl- erythromycin A To a solution of intermediate 37 (1.42g) in anhydrous DMF (l lOmL), sodium azide (0.211g) was added under nitrogen atmosphere. The mixture was heated to 80°C for lOmin then quenched with water (lOOmL) and extracted with EtOAc (3x200mL). The organic layer was dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (1.36g). mVz ([MH] + ) = 723. Intermediate 40 2'-O-Acetyl-12-aminoethanoyl-3-decladinosvI-ll-deoxy-10,ll-didehvdro-6-O-alIyl- erythromycin A To a solution of intermediate 39 (1.36g) in THF (25mL), friphenylphosphine (0.985g) and water (0.034mL) were added. The mixture was stirred at room temperature overnight. After evaporating the solvent, the residue was dissolved in DCM (lOOmL) and the solution washed with water (2x100). The organic layer was dried over Na 2 S0 4 and concenfrated under vacuum to give the title compound (1 ,30g). mVz ([MH] + ) = 697. Intermediate 41 2 , -O-Acetyl-12-(benzhvdrylidene)-aminoethanoyl-3-decIadinosyl-ll-deoxy-10,ll- didehvdro-6-O-allyl-erythromvcin A A solution of intermediate 40 (1.30g) and benzophenone imine (0.9mL) in anhydrous DCM (15mL) was stirred at room temperature under nitrogen atmosphere. After 30h the reaction was quenched with water (50mL) and extracted with DCM (3xl00mL). The organic layer was dried over Na 2 S0 4 , filtered and concentrated under vacuum to give the title compound (1.60g). mVz ([MH] + ) = 861. Intermediate 42 (llS.21R.S)-2 , -O-Acetyl-3-decladinosyl-ll < 12-dideoxy-6-O-allyl-12.11-loxycarbonyl- (benzhvdrylideneamino)-methylenel-ervthromvcin A A solution of intermediate 41 (1.60g) and DBU (0.3mL) in acetonitrile (90mL) and water (9mL) was stirred at room temperature for 2h. Then the solvents were evaporated and the crude material was dissolved in DCM (lOOmL). The mixture was washed with water (2xl00mL), the organic phase dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 3 9.5V0.4V0.03) to give the title compound (0.528g). mVz ([MH ) = 861. Intermediate 43 Methyl (4-pyridin-3-yl-l_-r-imidazol-l-yl)acetate To a stirred suspension of sodium hydride (0.769g) in anhydrous DMF (30mL) under nitrogen atmosphere, a solution of 3-(lH-imidazol-4-yl)-pyridine (3g) in anhydrous DMF (lOmL) was added dropwise at room temperature. The mixture was stirred for 30min then methyl bromoacetate (2.4mL) was added dropwise. After stirring for 2h the solvent was evaporated under reduced pressure, the residue diluted with EtOAc (200mL) and washed with water (50mL). The aqueous phase was further extracted with EtOAc (2x40mL). The organic layer was dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (2J8g). mVz ([MH] + ) = 218. Intermediate 44 Methyl 3-(4-pyridin-3-yl-l-_-r-imidazol-l-yl)-propionate To a stirred suspension of sodium hydride (0.165g) in anhydrous DMF (2.5mL) cooled at 0°C a solution of 3-(lH-imidazol-4-yl)-pyridine (lg) in anhydrous DMF (5mL) was added dropwise under nitrogen atmosphere. The mixture was stirred for 15min at room temperature then a solution of methyl 3-bromopropanoate (0.830mL) in anhydrous DMF (5mL) was added dropwise. After stirring for 2h at 70°C the solvent was evaporated under reduced pressure, the residue diluted with EtOAc (5 OmL) and washed with water (15mL). The aqueous phase was further extracted with EtOAc (3xl5mL). The combined organic layers were dried over Na 2 S0 4 , concenfrated under reduced pressure and the crude product was purified by flash chromatography (eluting with: DCMVMeOH from 95V5 to 90V10) to give the title compound (0.530g). mVz ([MH] + ) = 232. Intermediate 45 Methyl 4-(4-pyridin-3-yl-l---f-imidazol-l-yl butyrate To a stirred suspension of sodium hydride (0.745g) in anhydrous DMF (8mL) cooled at 0°C a solution of 3-(lH-imidazol-4-yl)-pyridine (3g) in anhydrous DMF (16mL) was added dropwise under nitrogen atmosphere. The mixture was stirred for 15min at room temperature then a solution of methyl 4-chloro-butanoate (2.76mL) in anhydrous DMF (16mL) was added dropwise. After stirring for 2.5h at 70°C the solvent was evaporated under reduced pressure, the residue diluted with EtOAc (150mL) and washed with water (50mL). The aqueous phase was further extracted with EtOAc (3x40mL). The combined organic layers were dried over Na 2 S0 4 , concentrated under reduced pressure and the crude product was purified by flash chromatography (eluting with: DCMVMeOH 96V4) to give the title compound (2.2g). mVz ([MH ) = 246. Intermediate 46 Methyl 5-(4-pyridin-3-yl-lH-imidazol-l-vI)pentanoate To a stirred suspension of sodium hydride (0.745g) in anhydrous DMF (8mL) cooled at 0°C a solution of 3-(lH-imidazol-4-yl)-pyridine (3g) in anhydrous DMF (16mL) was added dropwise under nitrogen atmosphere. The mixture was stirred for 15min at room temperature then a solution of methyl 5-bromo-pentanoate (3.55mL) in anhydrous DMF (16mL) was added dropwise. After stirring for 2h at 70°C the solvent was evaporated under reduced pressure, the residue diluted with EtOAc (150mL) and washed with water (50mL). The aqueous phase was further extracted with EtOAc (3x40mL). The combined organic layers were dried over Na 2 S0 , concenfrated under reduced pressure and the crude product was purified by flash chromatography (eluting with: DCMVMeOH 96V4) to give the title compound (4.25g). m\z ([MH] + ) = 260. Intermediate 47 Sodium (4-Pyridin-3-yl-imidazol-l-yl)-acetate To a solution of intermediate 43 (O.lOOg) in acetone (2mL) at room temperature IM NaOH aqueous solution (0.46mL) was added. The mixture was stirred at room temperature for 20h then to reflux for 8h. Solvent evaporation under reduced pressure gave the title compound (O.lOOg). mVz ([MH] + ) = 204. Intermediate 48 Sodium 3-(4-Pyridin-3-yl-imidazol-l-yl)-propionate To a solution of intermediate 44 (O.lOOg) in acetone (ImL) at room temperature IM NaOH aqueous solution (0.43mL) was added. The mixture was stirred at room temperature for 6h. Solvent evaporation under reduced pressure gave the title compound (0.099g). mVz ([MH] + ) = 218. Intermediate 49 Sodium 4-(4-Pyridin-3-yl-imidazoI-l-yl)-butyrate To a solution of intermediate 45 (O.lOOg) in acetone (ImL) at room temperature IM NaOH aqueous solution (0.40mL) was added. The mixture was stirred at room temperature for 6 h. Solvent evaporation under reduced pressure gave the title compound (0.096g). mVz ([MH ) ■ = 232. Intermediate 50 Sodium 5-(4-Pyridin-3-yl-imidazol-l-yI)-pentanoate To a solution of intermediate 46 (O.lOOg) in acetone (ImL) at room temperature IM NaOH aqueous solution (0.38mL) was added. The mixture was stirred at room temperature for 3 h. Solvent evaporation under reduced pressure gave the title compound (0.095g). mVz ([MH] + ) = 246. Intermediate 51 l-Methoxy-2-(4-pyridin-3-yl-lH-imidazoI-l-yl)ethanol To a stirred suspension of sodium hydride (0.166g) in anhydrous DMF (3mL) cooled to 0°C a solution of 3-(lH-imidazol-4-yl)-pyridine (lg) in anhydrous DMF (5mL) was added dropwise under nitrogen atmosphere. The reaction mixture was allowed to reach room temperature and after 15min a solution of bromoacetaldehyde dimethyl acetal (0.816mL) in anhydrous DMF (5mL) was added dropwise. The reaction mixture was stirred at 70°C for 4h and at room temperature overnight. After evaporating the solvent under reduced pressure the crude material was purified by flash chromatography (eluting with DCMVMeOH 90V10) to give the title compound (1.15g). mVz ([MH] + ) = 234 TLC: DCMVMeOH 90V10 (Rf=0.5). Intermediate 52 3-(4-Pyridin-3-yl-lH-imidazol-l-yl)propionaldehyde To a solution of 3-(lH-imidazol-4-yl)-pyridine (0.350g) in anhydrous TΗF (15mL) cooled at 0°C acrylaldehyde (0.540mL) was added dropwise. The resulting solution was stirred at room temperature for 3 days. Solvent evaporation under reduced pressure gave the title compound (0.460g). mVz ([MΗ] + ) = 202. Intermediate 53 4-(4-Pyridin-3-yl-lff-imidazol-l-yl)butan-l-ol To a solution of intermediate 45 (1.2g) in anhydrous THF (20mL) cooled at 0°C lithium aluminum hydride (IM in THF, 2.55mL) was added dropwise under nitrogen atmosphere. The reaction mixture was stirred for 2h at room temperature, then water (3 OmL) and EtOAc (75mL) were added. The solvents were evaporated under reduced pressure and the residue exfracted with EtOAc (2x75mL). The combined organic layers were washed with a saturated sodiumVpotassium tartrate aqueous solution (80mL), dried over Na 2 S0 4 , concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.600g) mVz ([MH] + ) = 218. Intermediate 54 4-(4-Pyridin-3-yl-lH-imidazol-l-yl)butyr aldehyde To a solution of oxalyl chloride (0.225mL) in anhydrous DCM (7mL) cooled to -78°C under nitrogen atmosphere a solution of DMSO (0.275mL) in anhydrous DCM (2mL) was slowly added. After 15 min at -78°C a solution of intermediate 53 (0.280g) in anhydrous DCM (5mL) was dropped within 30min. The mixture was stirred at - 0°C for 4h then TEA(0.900mL) was added. The reaction was allowed to reach room temperature then water (lOmL) was added. The mixture was exfracted with DCM (3x20mL), the organic phase dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH 90V10) to give the title compound (0.052g) mVz ([MH] + ) = 216. Intermediate 55 5-(4-Pyridin-3-yl-l-g-imidazol-l-yl pentan-l-ol To a solution of intermediate 46 (3.54g) in anhydrous THF (40mL) cooled to 0°C, lithium aluminum hydride (IM in THF, 7.8mL) was added dropwise under nitrogen atmosphere. The reaction mixture was stirred for 2.5h at room temperature then water (50mL), EtOAc (lOOmL) and a 28% NH OH aqueous solution until pH=9 were added. The solvents were evaporated under reduced pressure and the residue dissolved in EtOAc (2xl00mL). The solution was washed with a saturated sodiumVpotassium tartrate aqueous solution, dried over Na 2 S0 4 , concenfrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH from 95V5 to 90V10) to give the title compound (2.32g) TLC: DCMVMeOH 95V5 (Rf=0.18) Intermediate 56 5-(4-Pyridin-3-yl-l_r-r-imidazol-l-yI)pentanal To a solution of oxalyl chloride (0.755mL) in anhydrous DCM (25mL) cooled to -78°C under nitrogen atmosphere, a solution of DMSO (1.23mL) in anhydrous DCM (8mL) was slowly added. After 15min at -78°C a solution of intermediate 55 (lg) in anhydrous DCM (18mL) was added dropwise over 30min. The mixture was stirred at -40°C for 3.5h then TEA(3.6mL) was added. The reaction mixture was allowed to reach room temperature then water (5 OmL) was added. The mixture was exfracted with DCM (3xl00mL), the organic phase dried over Na 2 S0 , concenfrated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH 92V) to give the title compound (0.635g) mVz ([MH] + ) = 230. Intermediate 57 4-[ (-g.--D-2-Methoxyvinyll quinoline To a solution of (methoxymethyl)triphenylphosphonium chloride (3.27g) in anhydrous THF (60mL) cooled to -78°C sodium bis(trimethylsilyl)amide (IM in THF, 9.5mL) was added under nitrogen atmosphere and the solution was stirred for 15min. A solution of 4-quinoline carboxaldehyde (lg) in anhydrous THF (lOmL) was added and the reaction mixture was stirred at -78°C for 30min, at 0°C for 1.5h, then at room temperature overnight. The reaction was quenched with water (50mL) and exfracted with EtOAc (75mL). The aqueous phase was neutralised with a saturated NH 4 C1 (50ml) aqueous solution and extracted again with EtOAc (2x75mL). The combined organic layers were dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material purified by flash chromatography (eluting with: HexaneVEtOAc from 60V40 to 50V50) to give the title compound (0.905g). mVz ([MH] + ) = 186. Intermediate 58 4- 13-(1 ,3-Dioxolan-2-yl)propyll quinoline To a solution of [2-(l,3-dioxolan-2-yl)-ethylj-friphenylphosphonium bromide (10.6g) in anhydrous THF (150mL) cooled to -78C° a solution of sodium bis(trimethylsilyl)amide (IM in THF, 23.9mL) was added dropwise under nifrogen atmosphere. The mixture was stirred at -78°C for 30min then a solution of 4-quinoline carboxaldehyde (2.5g) in anhydrous THF (30mL) was added. The mixture was allowed to reach room temperature, DBU (1.8mL) was added and the mixture stirred for 6h at 50°C. The reaction was quenched with a saturated NH 4 C1 aqueous solution of (lOOmL) and extracted with EtOAc (3xl50mL). The organic phase was dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material filtered on a silica pad (eluting with: cyclohexaneVEtOAc 70V30). After evaporating the solvent under reduced pressure, the residue was dissolved in MeOH (20mL), palladium (lOwt. % on carbon powder, 0.360g) was added and the mixture stirred under hydrogen atmosphere (1.5 atm) for 2h. The mixture was filtered over a celite pad eluting with MeOH (2xl00mL) and purification by flash chromatography (eluting with: Et 2 0) gave the title compound (OJOQg). mVz ([MH] + ) = 244. Intermediate 59 4-Quinolin-4-yl-butyr aldehyde To a solution of intermediate 58 (0.500g) in acetone (5mL) a 2N HCl aqueous solution (5mL) was added and the mixture stirred at 50°C for 2h. After evaporation of the solvent under reduced pressure, NH OH was added to the residue until pH=9. Aqueous solution was extracted with DCM (2x35mL), the organic phase dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: EtOAcVcyclohexane 80V20) to give the title compound (0.315g). mVz ([MH] + ) = 200. Intermediate 60 4-Ouinolin-4-yI-butyric acid To a solution of intermediate 59 (0.160g) in acetone (4mL) potassium permanganate (0.063g) was added portionwise within lh. After solvent evaporation, water (4mL) was added and the mixture refluxed for 30min. The reaction mixture was slowly cooled to 0°C and kept at 0°C overnight. The reaction mixture was filtered through a celite pad eluting with DCM (5mL) and after removing the solvent under vacuum the crude product was purified by flash chromatography (eluting with: DCMVMeOH 90V10) to give the title compound (0.050g). mVz ([MH] + ) = 216. Intermediate 61 Ethyl 5-qmnolin-4-yl-pentanoate To a stirred suspension of [3-(ethoxycarbony_)-propyl]-friphenylphosphonium bromide (5.6g) in anhydrous THF (lOOmL) cooled to -78°C a solution of sodium bis(trimethylsilyl)amide (IM in THF, 12mL) was added dropwise under nifrogen atmosphere. The mixture was stirred at -78°C for lh then a solution of 4-quinoline carboxaldehyde (1.6g) in anhydrous THF (15mL) was dropped. The mixture was allowed to reach room temperature, stirred for 2h then heated to 50°C and stirred for 4h. The reaction was quenched with a saturated NH 4 C1 aqueous solution (50mL) and extracted with EtOAc (3xl00mL). The organic phase was dried over Na 2 S0 , concenfrated under reduced pressure and the crude material purified by filtration on a silica gel pad (eluting with: cyclohexaneVEtOAc 70V30). After evaporating the solvent under reduced pressure, the residue was dissolved in MeOH (lOmL), palladium (lOwt. % on carbon powder, 0.060g) was added and the mixture stirred under hydrogen atmosphere (1.5 atm) for lh. The mixture was filtered through a celite pad eluting with MeOH (2x50mL) and subsequent solvent evaporation under reduced pressure gave the title compound (0.860g). mVz ([MH] + ) = 258. Intermediate 62 5-Ouinolin-4-yl-pentanoic acid To a solution of intermediate 61 (0.194g) in acetone (ImL) at room temperature IM NaOH aqueous solution (0.78mL) was added. The mixture was refluxed for 2h. Solvent evaporation under reduced pressure gave the title compound (0.181g). mVz ([MH] + ) = 230. Intermediate 63 5-Ouinolin-4-yl-pentanal To a solution of intermediate 61 (0.050g) in anhydrous toluene (ImL) cooled to -78°C, diisobutylaluminium hydride (IM sol. in toluene, 0.39mL) was slowly added. The reaction mixture was stirred for lh at -78°C, then quenched with 2mL of a mixture of water (0.25mL), acetic acid (ImL) and Et 2 0 (3mL) at -78°C. The temperature was allowed to reach room temperature then the crude material was filtered through a celite pad eluting with DCM (3xl0mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (0.040g). mVz ([MH ) = 214. Intermediate 64 Methyl 3-(4-phenyl-l---- r -imidazol-l-yl)propionate To a stirred suspension of sodium hydride (0.017g) in anhydrous DMF (0.250mL) cooled at 0°C a solution of 4-phenyl-lH-imidazole (O.lOOg) in anhydrous DMF (0.8mL) was added dropwise under nifrogen atmosphere. The mixture was stirred for 15min at room temperature then a solution of 3-bromo-propionic acid methyl ester (0.083mL) in anhydrous DMF (0.3mL) was added dropwise. After stirring for 2h at 70°C the solvent was evaporated under reduced pressure, the residue diluted with EtOAc (5mL) and washed with water (3mL). The aqueous phase was further extracted with EtOAc (3x5mL). The combined organic layers were dried over Na 2 S0 4 , concenfrated under reduced pressure and the crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 95V5) to give the title compound (0.128g). mVz ([MH] + ) = 231. Intermediate 65 Sodium 3-(4-Phenyl-imidazol-l-yl -propionate To a solution of intermediate 64 (0.034g) in acetone (0.50mL) at room temperature a IM NaOH aqueous solution (0.15mL) was added. The mixture was stirred at room temperature for 3h. Solvent evaporation under reduced pressure gave the title compound (0.035g). mVz ([MH] + ) = 217. Intermediate 66 Methyl (4-phenyl-lH-imidazol-l-yl acetate To a stirred suspension of sodium hydride (0.037g) in anhydrous DMF (0.550mL) cooled at 0°C a solution of 4-phenyl-lH-imidazole (0.200g) in anhydrous DMF (1.6mL) was added dropwise under nifrogen atmosphere. The mixture was stirred for 15min at room temperature then a solution of 2-chloro-acetic acid methyl ester (0.134mL) in anhydrous DMF (0.60mL) was added dropwise. After stirring for 2h at 70°C and overnight at room temperature the mixture was diluted with Et 2 0 (25mL) and washed with water (lOmL). The aqueous phase was further extracted with Et 2 0 (3xl5mL). The collected organic extracts were dried over Na 2 S0 , concenfrated under reduced pressure and the crude product was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 96\4) to give the title compound (0.210g). mVz ([MH] + ) = 217. Intermediate 67 Sodium 3-(4-Phenv_-imidazoI-l-yl)-propionate To a solution of intermediate 66 (0.190g) in acetone (2.5mL) at room temperature, a 1.2M NaOH aqueous solution (0.730mL) was added. The mixture was stirred at room temperature for 2.5h and then solvent evaporation under reduced pressure gave the title compound (0.205g). mVz ([MH] + ) = 203 Intermediate 68 Methyl 3-(4-thien-2-yl-lH-imidazol-l-yl propionate To a stirred suspension of sodium hydride (0.013g) in anhydrous DMF (0.250mL) cooled at 0°C a solution of 4-thiophen-2-yl-lH-imidazole (O.lOOg) in anhydrous DMF (1.6mL) was added dropwise under nitrogen atmosphere. The mixture was stirred for 15min at room temperature then a solution of methyl 3-bromopropionate (O.lOOmL) in anhydrous DMF (0.3mL) was added dropwise. After stirring for 5h at 70°C and overnight at room temperature the solvent was evaporated under reduced pressure, the residue dissolved with EtOAc (5mL) and the solution washed with water (3mL). The aqueous phase was further extracted with EtOAc (3x5mL). The combined organic layers were dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 95V5) to give the title compound (0.013g). m\z ([MH] + ) = 237. Intermediate 69 Sodium 3-(4-thien-2-yl-lH-imidazol-l-yl propionate To a solution of intermediate 68 (0.013g) in acetone (0.3mL) at room temperature, a IM NaOH aqueous solution (0.055mL) was added. The mixture was stirred at room temperature for 5h and then solvent evaporation under reduced pressure gave the title compound (0.012g). mVz ([MH] + ) = 223. Intermediate 70 Sodium 3-(3-thiazol-2-yl-pyrazol-l-vD-propionate To a stirred suspension of sodium hydride (0.016g) in anhydrous DMF (0.3mL) cooled at 0°C a solution of 2-(lH-pyrazol-3-yl)-thiazole (O.lOOg) in anhydrous DMF (0.8mL) was added dropwise under nifrogen atmosphere. The mixture was stirred for 15min at room temperature then a solution of 3-bromo-propionic acid methyl ester (0.080mL) in anhydrous DMF (0.3mL) was added dropwise. After stirring for 4h at 70°C the solvent was evaporated under reduced pressure, the residue diluted with EtOAc (5mL) and washed with water (3mL). The aqueous phase was further extracted with EtOAc (3x5mL). The combined organic layers were dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was dissolved in acetone (ImL) and a 1.2N NaOΗ aqueous solution (0.55mL) was added. The mixture was stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.025 ). m\z ([MΗ] + ) = 224. Intermediate 71 Ethyl f (3-methoxyquinoxalin-2-vDthio1 acetate To a solution of 2-chloro-3-methoxy-quinoxaline (O.lOOg) in anhydrous DMF (3mL) potassium carbonate (0.142g) and mercapto-acetic acid ethyl ester (0.084mL) were added and the resulting mixture was stirred at 80°C for 1.5h. The solvent was removed under reduced pressure, water (5mL) was added and the mixture was extracted with EtOAc (3xl0mL). The combined organic phases were washed with brine (5mL), dried over Na 2 S0 and evaporated under reduced pressure. The crude material was purified by flash chromatography (eluting with: cyclohexaneVEtOAc 80V20) to afford the title compound (0.065g). mVz ([MHj÷) = 255 TLC: cyclohexaneVEtOAc 80V20 (RpO.57). Intermediate 72 [(3-Methoxyquinoxalin-2-yl thio1 acetic acid To a solution of intermediate 71 (0.060g) in THF (2mL) a 3N NaOH aqueous solution (2mL) was added. The mixture was vigorously stirred at room temperature overnight, then after solvent evaporation, a IN HCl aqueous solution was added until pH=l. The solution was extracted with DCM (3x8mL), the organic phase was washed with brine (5mL), dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (0.045g). mVz ([MH] + ) = 227 TLC: EtOAcVMeOH 98V2 (R f =0.48) Intermediate 73 Ethyl (quinoxalin-2-yloxy acetate To a solution of quinoxalin-2-ol (2g) in acetone (30mL) potassium carbonate (3.8g) and chloroacetic acid ethyl ester (2.2mL) were added and the resulting mixture was stirred at reflux for 6h. After evaporating the solvent under reduced pressure, water (3 OmL) was added and the mixture extracted with EtOAc (3x50mL). The organic phase was washed with brine (30mL) dried over Na 2 S0 and evaporated under reduced pressure. The crude material was purified by flash chromatography (eluting with: cyclohexaneVEtOAc 3V2) to afford the title compound (1.5g). mVz ([MH] + ) = 233. Intermediate 74 (OuinoxaIin-2-yl-oxy)acetic acid To a solution of intermediate 73 (0.300g) in THF (lOmL) a 3N NaOH aqueous solution (lOmL) was added. The mixture was vigorously stirred at room temperature for lh, then after evaporation of the solvent, a IN HCl aqueous solution was added until pH=l. The aqueous solution was extracted with DCM (3x20mL), the organic phase was washed with brine (lOmL), dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (0.230g). mVz ([MH] + ) = 205 Intermediate 75 3-[4-(3,5-Difluorophenyl -lH-pyrazol-l-vIlpropionaldehyde To a solution of 4-(3,5-difluoro-phenyl)-lH-pyrazole (0.050g) in anhydrous acetonitrile (2mL), acrylaldehyde (0.050mL) was added portionwise. The resulting solution was stirred at 55°C for 16h and then the solvent was removed under reduced pressure to give the title compound (0.52g). mVz ([MΗ] + ) = 237 Intermediate 76 3-.4-(4-Chlorophenyl)-2,5-dimethyl-lH-imidazol-l-vI]propionaldehvde To a solution of 4-(4-chloro-phenyl)-2,5-dimethyl-lH-imidazole (0.030g) in anhydrous acetonitrile (3mL), acrylaldehyde (0.069mL) was added portionwise. The resulting solution was stirred at 50°C for 24h and then the solvent was removed under reduced pressure to give the title compound (0.036g). mVz ([MΗ] + ) = 263 Intermediate 77 3-[4-(4-Nitrophenyl)-lH-imidazol-l-yllpropionaldehyde To a solution of 4-(4-nitro-phenyl)lH-imidazole (O.lOOg) in anhydrous acetonitrile (12mL), acrylaldehyde (0.450mL) was added portionwise. The resulting solution was stirred at 50°C for 5 days. Solvent was removed under reduced pressure to give the title compound (0.120g). Intermediate 78 3-(4-Pyridin-4-V--imidazol-l-yl)-propionaldehvde To a solution of 4-(lH-imidazol-4-yl)-pyridine (0.040g) in anhydrous acetonitrile (2mL) acrylaldehyde (0.050mL) was added portionwise. The resulting solution was stirred at 55°C for 8h and at room temperature overnight. Solvent was removed under reduced pressure to give the title compound (0.42g). mVz ([MH] + ) = 202 Intermediate 79 3-(3-Trifluoromethyl-lH-pyrazol-4-yl)-propionaldehvde To a solution of oxalyl chloride (0.127mL) in anhydrous DCM (4mL) cooled to -78°C under nitrogen atmosphere DMSO (0.155mL) was slowly added. After stirring for 30min at -78°C a solution of 3-(3-frifluoromethyl-lH-pyrazol-4-yl)-propan-l-ol (0.094mL) in anhydrous DCM (3mL) was added dropwise. The mixture was stirred at — 40°C for 3h then TEA(0.507mL) was added. The reaction was allowed to reach room temperature then a saturated NaΗC0 3 aqueous solution (lOmL) was added and the mixture extracted with DCM (3xl0mL). The organic phase was washed with brine (lOmL), dried over Na 2 S0 4 and concenfrated under reduced pressure to give the title compound (O.lOOg) mVz ([MH] + ) = 193 Intermediate 80 3-f5-Methyl-4-(4-trifluoromethyl-phenyl)-imidazol-l-yll-propionaldehvde To a solution of 5-methyl-4-(4-frifiuoromethyl-phenyl)-lH-imidazole (0.030g) in anhydrous acetonitrile (2mL) acrylaldehyde (0.027mL) was added. The resulting solution was stirred at 50°C for 24h and at room temperature for 12h. Solvent was removed under reduced pressure to give the title compound (0.038g). mVz ([MΗ ) = 283 Intermediate 81 3-Pyridin-3-yl-propionaldehyde To a solution of oxalyl chloride (0.127mL) in anhydrous DCM (4mL) cooled to -78°C under nifrogen atmosphere DMSO (0.155mL) was slowly added. After 20min at -78°C a solution 3- pyridin-3-yl-propan-l-ol (O.lOOg) in anhydrous DCM (3mL) was added dropwise within 30min. The mixture was stirred at -40°C for 3h then TEA(0.507mL) was added. The reaction was allowed to reach room temperature then water (5mL) was added. The mixture was extracted with DCM (3xl0mL), the organic phase dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 95V5) to give the title compound (0.052g) mVz ([MH] + ) = 136 Intermediate 82 3-(4-Pyridin-2-yl-pyrazol-l-yl)-propionaldehyde To a solution of 2-(lH-pyrazol-4-yl)-pyridine (0.058g) in anhydrous acetonitrile (2mL) acrylaldehyde (0.022mL) was added. The resulting solution was stirred at 50°C for 3h. Solvent was removed under reduced pressure to give the title compound (0.060g). mVz ([MΗ] + ) = 202 Intermediate 83 3-Pyridin-4-yl-propionaldehyde To a solution of oxalyl chloride (0.127mL) in anhydrous DCM (3mL) cooled to -70°C under nitrogen atmosphere, a solution of DMSO (0.155 L) in anhydrous DCM (2mL) was added dropwise. The reaction mixture was stirred for 30min then a solution of 3-pyridin-4-yl- propan-1-ol (O.lOOg) in anhydrous DCM (2mL) was added dropwise in 30min. The mixture was stirred at -60°C for 3h then the reaction mixture was allowed to reach -10°C and TEA (0.507mL) was added. The reaction was stirred overnight reaching slowly the room temperature. A saturated NaHC0 3 aqueous solution (5mL) was added, the organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (O.lOOg). Intermediate 84 3-(4-Pyrimidin-4-yl-pyrazol-l-yl)-propionaldehyde To a solution of 4-(lH-pyrazol-4-yl)-pyrimidine (0.022g) in anhydrous acetonitrile (2mL) acrylaldehyde (0.020mL) was added. The reaction mixturewas stirred at 50°C for 1.5h. Solvent was removed under reduced pressure to give the title compound (0.025g). mVz ([MΗ] + ) = 203 Intermediate 85 3-(4-Pyridin-4-yl-pyrazol-l-yl)-propionaldehvde To a solution of 2-(lH-pyrazol-4-yl)-pyridine (0.050g) in anhydrous acetonitrile (2mL) acrylaldehyde (0.220mL) was added. The resulting solution was stirred at 50°C for 4h and at room temperature overnight. Solvent was removed under reduced pressure to give the title compound (0.050g). mVz ([MΗ] + ) = 202 Intermediate 86 3-f4-(3,5-Dichloro-phenyl -2,5-dimethyl-imidazol-l-vIl-propionaldehyde To a solution of 4-(3,5-dichloro-phenyl)-2,5-dimethyl-lH-imidazole (0.035g) in anhydrous acetonitrile (3mL) acrylaldehyde (0.116mL) was added portionwise. The resulting solution was stirred at 50°C for 56h. Solvent was removed under reduced pressure to give the title compound (0.029g). mVz ([MΗ] + ) = 297 Intermediate 87 3-f2-5-Dimethyl-4-(3-trifluoromethyl-phenyl)-imidazol-l-vn-propionaldehvde To a solution of 2,5-dimethyl-4-(3-trifluoromethyl-phenyl)-lH-imidazole (0.037g) in anhydrous acetonitrile (3mL) acrylaldehyde (0.120mL) was added portionwise. The resulting solution was stirred at 50°C for 48h. Solvent was removed under reduced pressure to give the title compound (0.042g). mVz ([MH] + ) = 297 Intermediate 88 3- [4-(l ,3-benzoxazol-2-yl)-lH-pyrazol-l-vn -propionaldehyde To a stirred suspension of 2-(lH-pyrazol-4-yl)-l,3-benzoxazole (0.053g) in anhydrous acetonitrile (2mL) acrylaldehyde (0.220mL) was added. The reaction mixture was stirred at 50°C for 6h. After filtration the solvent was removed under reduced pressure to give the title compound (0.034g). mVz ([MΗ] + ) = 242 Intermediate 89 3-(5-Pyridin-4-yl-pyrazol-l-yl)-propionaldehyde To a solution of 4-(lH-pyrazol-3-yl)-pyridine (0.030g) in anhydrous acetonitrile (ImL) acrylaldehyde (0.085mL) was added. The reaction mixture was stirred at 50°C for 48h. Solvent was removed under reduced pressure to give the title compound (0.036g). mVz ([MΗ] + ) = 202. Intermediate 90 3-(2-Pyridin-4-yl-imidazol-l-yl)-propionaldehvde To a solution of 4-(lH-imidazol-2-yl)-pyridine (0.050g) in anhydrous acetonitrile (3mL) acrylaldehyde (O.OSOmL) was added. The reaction mixture was stirred at 50°C for 14h. Solvent was removed under reduced pressure to give the title compound (0.050g). mVz ([MΗ] + ) = 202 Intermediate 91 3-(4-Ouinolin-2-yl-lH-pyrazol-l-yl -propionaldehyde To a solution of 2-(lH-pyrazol-4-yl)quinoline (0.050g) in anhydrous acetonitrile (5mL) acrylaldehyde (0.116mL) was added. The reaction mixture was stirred at 50°C for 3 days. Solvent was removed under reduced pressure to give the title compound (0.050g). mVz ([MΗ] + ) = 252 Intermediate 92 3-(4-Ouinolin-4-vI-l-H-pyrazol-l-yl)-propionaIdehvde To a solution of 4-(lH-pyrazol-4-yl)quinoline (0.050g) in anhydrous acetonitrile (4mL) acrylaldehyde (0.260mL) was added. The reaction mixture was stirred at 50°C for 7 days. Solvent was removed under reduced pressure to give the title compound (0.050g). mVz ([MΗ] + ) = 252 Intermediate 93 3-(4-Quinoxaϋn-2-yl-l-ff-pyrazol-l-yl)-propionaldehvde To a solution of 2-(lH-pyrazol-4-yl)quinoxaline (0.050g) in anhydrous acetonitrile (4mL) acrylaldehyde (0.156mL) was added. The reaction mixture was stirred at 50°C for 3 days. Solvent was removed under reduced pressure to give the title compound (0.050g). mVz ([MΗ] + ) ■ = 253 Intermediate 94 3-Thien-3-yl-propionaIdehyde To a solution of oxalyl chloride (0.190mL) in anhydrous DCM (6mL) cooled to -78°C under nitrogen atmosphere a solution of DMSO (0.230mL) in anhydrous DCM (4mL) was slowly added. After stirring for 30min at -78°C a solution of 3-thien-3-ylpropan-l-ol (0.150g) in anhydrous DCM (4mL) was added dropwise. The mixture was stirred at - 0°C for 3h then TEA(0J50mL) was added. The reaction was allowed to reach room temperature then a saturated NaHC0 3 aqueous solution (lOmL) was added and the mixture exfracted with DCM (3x1 OmL). The organic phase was washed with brine (lOmL), dried over Na 2 S0 and concenfrated under reduced pressure to give the title compound (0.140g) mVz ([MH] 4 ) = 141 Intermediate 95 3-.5-(3-Methyl-pyrazin-2-viypyrazol-l-yll-propionaldehyde To a solution of 2-methyl-3-(2H-pyrazol-5-yl)-pyrazine (0.030g) in anhydrous acetonitrile (ImL) acrylaldehyde (0.065mL) was added. The reaction mixture was stirred at 50°C for 60h. Solvent was removed under reduced pressure to give the title compound (0.038g). mVz ([MΗ] + ) = 217. Intermediate 96 3-f2-(MethvIthioyiH-benzimidazol-l-yll-propionaIdehyde To a solution of 2-(methylthio)-lH-benzimidazole (0.030g) in anhydrous acetonitrile (ImL) acrylaldehyde (O.OSOmL) was added. The reaction mixture was stirred at 50°C for 48h. Solvent was removed under reduced pressure to give the title compound (0.039g). mVz ([MΗ] + ) = 221 Intermediate 97 3- 13-f 4-Chlorophenyl)-lH-pyr azol-5-yll -pr opionaldehyde To a stirred suspension of Dess-Martin periodinane (0.163g) in anhydrous DCM (4mL) 3-[3- (4-chlorophenyl)-lH-pyrazol-5-yl]propan-l-ol (0.050g) was added and the mixture was stirred at room temperature overnight. The reaction was quenched with a Na 2 S 2 0 3 solution (5% in a saturated NaΗC0 3 aqueous solution, 3mL), stirred for lh then extracted with DCM (lOmL). The organic phase washed with brine (5mL), separated, dried over Na 2 S0 and concentrated under reduced pressure to give the title compound (0.040g). mVz ([MH] + ) = 235 Intermediate 98 3- [6- Methylthio -7---- r -purin-7-vn -pr opionaldehyde To a solution of 6-(methylthio)-7H-purine (0.032g) in anhydrous acetonitrile (3mL) acrylaldehyde (0.040mL) was added. The reaction mixture was stirred at 80°C for 8h and overnight at room temperature. Solvent was removed under reduced pressure to give the title compound (0.042g). mVz ([MΗf ) = 223 Intermediate 99 3-(6-Methoxy-7-Η-purin-7-yr,-propionaldehyde To a solution of 6-methoxy-7H-purine (0.040g) in anhydrous acetonitrile (3mL) acrylaldehyde (0.057mL) was added. The reaction mixture was stirred at 80°C for 8h. Solvent was removed under reduced pressure to give the title compound (0.055g). mVz ([MΗ] + ) = 207 Intermediate 100 3-(6-Methoxy-2-oxo-l,3-benzoxazol-3(2---Q-yl)-propionaldehyde To a solution of 6-methoxy-l,3-benzoxazol-2(3H)-one (0.072g) in anhydrous acetonitrile (2mL) was added acrylaldehyde (0.060mL). The reaction mixture was stirred at 50°C for 3h. Solvent was removed under reduced pressure to give the title compound (0.080g). mVz ([MH] + ) = 222 Intermediate 101 3-(lH-Pyrrolo 12,3-61 pyridin-1-vD -propionaldehyde To a solution of lH-pyrrolo[2,3-b]pyridine (0.040g) in anhydrous acetonitrile (3mL), acrylaldehyde (0.07 ImL) was added. The reaction mixture was stirred at 80°C for 6h and then the solvent was removed under reduced pressure to give the title compound (0.042g). mVz ([MΗ] + ) = 175 Intermediate 102 3-r3-(2,4-Dimethyl-l,3-thiazol-5-yl -lH-pyrazol-l-yllpropionaldehvde To a solution of 2,4-dimethyl-5-(lH-pyrazol-3-yl)-l,3-thiazole (0.032g) in anhydrous acetonitrile (ImL) acrylaldehyde (0.040mL) was added. The reaction mixture was stirred at 50°C for 5h and then at room temperature for 3 days. Solvent evaporation under reduced pressure gave the title compound (0.042g). mVz ([MΗ] + ) = 236 Intermediate 103 3-(3_g-Imidazo 14,5-cl pyridin-3-yl propionaldehvde and 3-(l_g-Imidazo [4,5-cl pyridin-l-yl propionaldehvde To a solution of 3H-imidazo[4,5-c]pyridine (0.050g) in anhydrous acetonitrile (4mL) acrylaldehyde (0.025mL) was added. The reaction mixture was stirred at 80°C overnight and then solvent was removed under reduced pressure to give a 1V1 mixture of the title compounds (0.050g). mVz ([MH] + ) = 176 Intermediate 104 3-(l-H-Benzimidazol-l-yl) propionaldehyde To a solution of lH-benzimidazole (0.050g) in anhydrous acetonitrile (4mL) acrylaldehyde (0.160mL) was added. The reaction mixture was stirred at 80°C overnight and then the solvent was removed under reduced pressure to give the title compound (0.050g). mVz ([MΗ] + ) = 175 Intermediate 105 3-( 3-H-Imidazo [4,5-61 pyridin-3-yl)propionaldehyde To a solution of 3H-_midazo[4,5-b]pyridine (0.050g) in anhydrous acetonitrile (3mL) acrylaldehyde (0.250mL) was added. The reaction mixture was stirred at 80°C for 24h and then the solvent was removed under reduced pressure to give the title compound (0.050g). mVz ([MΗ] + ) = 176 Intermediate 106 2-(3,3-Dimethoxy-propyIsulfanyl)-quinoxaIine To a solution of 2-quinoxalinethiol (0.200g) in a mixture of anhydrous dioxaneVDMF 4V1 (5mL) sodium hydride (80% mineral oil, 0.044g) was added portionwise under a nitrogen atmosphere and the reaction mixture stirred at room temperature for 15min. Then 3- bromopropionaldheyde dimethyl acetal (0.200mL) was added and the solution was heated to 80°C for 1.5h. After dilution at room temperature with EtOAc (5mL), the solution was concenfrated under reduced pressure, diluted with water (lOmL) and extracted with EtOAc (3xl0mL). The combined organic phases were then washed with brine (lOmL), dried over Na 2 S0 , and concentrated under vacuum to give a crude material that was purified by flash chromatography (eluant: cyclohexaneVEtOAc 3V1) to afford the title compound (0.280g). mVz ([MH] + ) =265. TLC: CyclohehaneVEtOAc 7V3 (Rf=0.47). Intermediate 107 3-(4-PhenvI-l--y-imidazoI-l-yl)propionaIdehyde To a solution of 4-ρhenyl-lH-imidazole (0.050g) in anhydrous acetonitrile (4mL) acrylaldehyde (0.210mL) was added. The reaction mixture was stirred at 80°C for 24h and then the solvent was removed under reduced pressure to give the title compound (0.050g). mVz ([MΗ] + ) =201. Intermediate 108 4-fl-(2.2-Dimethoxyethyl -lH-imidazol-4-yllpyridine To a stirred suspension of sodium hydride (0.009g) in anhydrous DMF (0.5mL) 4-(lH- imidazol-4-yl)pyridine (0.040g) was added under nitrogen atmosphere and the reaction mixture was stirred at room temperature for 30min. Then 2-bromoacetaldheyde dimethyl acetal (0.040mL) was added and the solution was heated to 70°C for 8h. After cooling to room temperature the solvent was evaporated to give the title compound (0.064g) mVz ([MΗ] + )=234 Intermediate 109 2-(2,2-Dimethoxy-ethylsulfanyl)-quinoxaline To a solution of 2-quinoxalinethiol (0.200g) in a mixture of anhydrous dioxaneVDMF 4V1 (5mL) sodium hydride (80% mineral oil, 0.044g) was added portionwise under nifrogen atmosphere and the reaction mixture stirred at room temperature for 15min. Then 2- bromoacetaldheyde dimethyl acetal (0.175mL) was added and the solution was heated to 80°C for 4.5h. After dilution at room temperature with EtOAc (5mL), the solution was concenfrated under reduced pressure, diluted with water (lOmL) and extracted with EtOAc (3xl0mL). The combined organic phases were washed with brine (lOmL), dried over Na 2 S0 , evaporated under vacuum obtaining a crude product that was purified by flash chromatography (eluting with: CyclohexaneVEtOAc 3V1) afforded the title compound (0.167g). mVz ([MH] + )= 251. TLC: CyclohexaneVEtOAc 7V3 (Rf=0.52). Intermediate 110 3-(4-(Thiophen-2-yl)-imidazoI-l-vD-propionaldehyde To a solution of 4-thiophen-2-yl-lH-imidazole (0.030g) in anhydrous acetonitrile (3mL) TEA(0.022mL) was added. After stirring at room temperature for 15min acrylaldehyde (0.034mL) was added dropwise and the resulting solution was heated to 75°C for 8h and then the solvent was removed under reduced pressure to give the title compound (0.033g). mVz ([MΗ] + ) = 207. Intermediate 111 3-(6-Methyl-2-oxo-l,3-benzoxazol-3(2H)-yl propanal To a solution of 6-methyl-l,3-benzoxazol-2(3H)-one (0.030g) in anhydrous acetonitrile (2mL) acrylaldehyde (0.060mL) was added. The reaction mixture was stirred at 50°C for 48h and then the solvent was removed under reduced pressure to give the title compound (0.040g). mVz ([MH] + ) = 206. Intermediate 112 4-ri-(2,2-dimethoxyethyl)-lH r -imidazol-2-vnpyridine To a stirred suspension of sodium hydride (0.009g) in anhydrous DMF (0.5mL) 4-(lH- imidazol-2-yl)pyridine (0.040g) was added under nitrogen atmosphere and the reaction mixture was stirred at room temperature for 30min. Then 2-bromoacetaldheyde dimethyl acetal (0.040mL) was added and the solution was heated to 70°C for 30h. After cooling to room temperature the solvent was evaporated under vacuum to give the title compound (0.064g) mVz ([MH] + )=234 Intermediate 113 3,4-Dimethyl-5-fl-(3-oxopropyl)-l---- r -l,2,4-triazol-3-vnthiophene-2-carbonitrile To a solution of 3,4-dimethyl-5-(lH-l,2,4-friazol-3-yl)thiophene-2-carbonifrile (0.037g) in anhydrous acetonitrile (ImL) acrylaldehyde (0.040mL) was added and the resulting solution was heated to 50°C for 5h. Solvent evaporation under vacuum gave the title compound (0.046g). mVz ([MΗ] + )=261 Intermediate 114 3-OuinoIin-3-vI-propionaldehyde To a solution of oxalyl chloride (0.290mL) in anhydrous DCM (8mL) cooled to -78°C under nitrogen atmosphere DMSO (0.340mL) was slowly added. After lh at -78°C a solution of 3- quinolin-3-ylpropan-l-ol (0.300g) in anhydrous DCM (3mL) was added. After stirring at - 40°C for 3h TEA(0.892mL) was added and the reaction mixture was allowed to reach room temperature. Water (lOmL) was added and the mixture was extracted with DCM (3xl0mL), the organic phase dried over Na 2 S0 4 and concenfrated under reduced pressure to give the title compound (0.290g) mVz ([MH] + )=186. Intermediate 115 3-[4-(3-Nitrophenyl)-l---J r -imidazol-l-yllpropanal To a solution of 4-(3-nifrophenyl)-lH-imidazole (0.040g) in anhydrous acetonitrile (5mL) acrylaldehyde (0.120mL) was added and the resulting solution was heated to 80°C and stirred for 4 days. The solvent was removed under reduced pressure to give the title compound (0.041g). mVz ([MΗ] + ) = 246. Intermediate 116 l-(2,3-Dihydro-l,4-benzodioxin-6-yl butane-l,4-diol To a solution of lithium aluminum hydride (IM in THF, 9.53mL) in anhydrous THF (15mL) cooled to 0°C a solution of 4-(2,3-dihydro-l,4-benzodioxin-6-yl)-4-oxobutyric acid (0.750g) in anhydrous THF (5mL) was added dropwise. The reaction mixture was heated to reflux for 24h, then it was cooled to room temperature and diluted with EtOAc (lOmL). After evaporation of the solvents under reduced pressure the crude material was treated with a IN HCl aqueous solution (20mL) and DCM (lOOmL). The organic phase was washed with a saturated NaHC0 3 aqueous solution (50mL), brine (50mL), dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (EtOAcVcyclohexane from 50V50 to 100V0) to give the title compound (0.340g). mVz ([MH] + )=225 Intermediate 117 4-(2,3-Dihvdro-l,4-benzodioxin-6-yl)-4-oxobutanal To a solution of oxalyl chloride (0.560mL) in anhydrous DCM (5mL) cooled to -78°C under nitrogen atmosphere a solution of DMSO (0.910mL) in anhydrous DCM (5mL) was slowly added. After stirring for 30min at -78°C a solution of intermediate 116 (0.340g) in anhydrous DCM (2mL) was added dropwise. The reaction mixture was stirred at -40°C for 3h then TEA(2.5mL) was added and then the reaction mixture was allowed to reach room temperature. A saturated NaHC0 3 aqueous solution (20mL) was added and the mixture extracted with DCM (3x20mL). The organic phase was washed with brine (20mL), dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (EtOAcVcyclohexane 40V60) to give the title compound (0.250g). mVz ([MH] + )=221 Intermediate 118 l-f2-(l,3-Dioxolan-2-yl)ethyll-5-methoxy-l---r-pyrrolof3.2-blpyridine To a solution of 5-methoxy-lH-pyrrolo[3,2-b]pyridine (0.040g) in anhydrous TΗF (1.5mL) cooled to 0°C, sodium hydride (O.OlOg) was added under nitrogen atmosphere. The mixture was stirred at room temperature for lh then 2-(2-bromoethyl)-l,3-dioxolane (0.038mL) was added and the stirring continued for an additional 6h. The reaction mixture was quenched with water (3mL) and exfracted with DCM (3x5mL), the organic phase dried over Na 2 S0 4 and concenfrated under reduced pressure to give the title compound (0.067). mVz ([MΗ] + )=249. Intermediate 119 2-fl-f2,2-Dimethoxyethyl -lH-pyrazol-3-yll-l,3-thiazole To a stirred suspension of sodium hydride (0.005g) in anhydrous DMF (0.5mL) at 0°C, under nitrogen atmosphere, a solution of 2-(lH-pyrazol-3-yl)-l,3-thiazole (0.030g) in anhydrous DMF (ImL) was added. The mixture was allowed to reach room temperature and stirred for an additional 15min and then a solution of bromoacetaldehyde dimethylacetal (0.024mL) in anhydrous DMF (0.5mL) was added. After stirring the reaction mixture at room temperature for 24h, the solvent was evaporated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCM) to give the title compound (0.015g). mVz ([MΗ] + ) = 240. Intermediate 120 l-(2,2-Dimethoxyethyl -4-phenyl-lH-imidazole To a stirred suspension of sodium hydride (0.005g) in anhydrous DMF (0.7mL) at 0°C a solution of 4-phenyl-lH-imidazole (0.023g) in anhydrous DMF (ImL) was added under nitrogen atmosphere. The mixture was allowed to reach room temperature and stirred for an additional 15min, then a solution of bromoacetaldehyde dimethylacetal (0.022mL) in anhydrous DMF (0.7mL) was added. After stirring the reaction mixture at room temperature for 24h the solvent was evaporated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 90V10) to give the title compound (0.027g). mVz ([MH] + ) = 233. Intermediate 121 l-(2,2-DimethoxyethvI)-4-thien-2-yl-lH-imidazole To a stirred suspension of sodium hydride (0.019g) in anhydrous DMF (3mL) at 0°C, under nitrogen atmosphere, a solution of 4-thien-2-yl-lH-imidazole (O.lOOg) in anhydrous DMF (ImL) was added. The mixture was allowed to reach room temperature, stirred for an additional 15min and then a solution of bromoacetaldehyde dimethylacetal (0.090mL) in anhydrous DMF (ImL) was added. After stirring at room temperature for 24h the solvent was evaporated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 99V1) to give the title compound (0.088g). mVz ([MH] + ) = 239. Example 1 (ll-y.21-R)-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12Jl- lbxycarbonv--(cvano)-methylenel -erythromycin A To a solution of intermediate 3 (0.060g) in anhydrous DMF (16mL) potassium cyanide (0.05 lg) was added under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 2h, quenched with a saturated NaHC0 3 aqueous solution (3 OmL) and extracted with DCM (3x30mL). The organic phase was then washed with brine (30mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.017g). ! H-NMR (CDC1 3 ) δ: 5.27(dd, IH), 4.74 (dd, IH), 4.62 (d, IH), 4.42 (d, IH), 4.26 (d, IH), 3.84 (q, IH), 3.56 (m, IH), 3.16 (m, IH), 3.10-3.0 (m, 2H), 2.77(s, 3H), 2.68 (m, IH), 2.60 (m, IH), 2.25 (s, 6H), 2.05 (m, 3H), 1.90 (m, IH), 1.68 (m, IH), 1.63 (m, 2H), 1.56 (s, 3H), 1.39 (d, 3H), 1.35 (m, IH), 1.30 (s, 3H), 1.26 (d, 3H), 1.18 (d, 3H), 1.14 (d, 3H), 1.06 (d, 3H), 0.92 (t, 3H). TLC: DCMVMeOH 95V5 (Rf=0.57). Example 2 (ll-S',21i_)-3-Decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonvI-(cvano)- methylenel-ervthromycin A A solution of example 1 (0.024g) in MeOH (ImL) was stirred for 24h then concenfrated under reduced pressure to give the title compound (0.020g). 'H-NMR (CDCI 3 ) δ: 5.26 (dd, IH), 4.61 (d, IH), 4.34 (d, IH), 4.28 (m, IH), 3.87 (q, IH), 3.57 (m, IH), 3.18 (m, IH), 3.15 (t, IH), 3.12 (m, IH), 3.06 (m, IH), 2.78 (s, 3H), 2.62 (m, IH), 2.46 (m, IH), 2.27 (s, 6H), 1.91 (m, IH), 1.84 (m, IH), 1.70 (m, IH), 1.68 (m, IH), 1.62 (m, IH), 1.57 (s, 3H), 1.41 (d, 3H), 1.34 (d, 3H), 1.34 (s, 3H), 1.24 (m, IH), 1.26 (d, 3H), 1.14 (d, 3H), 1.07 (d, 3H), 0.92 (t, 3H). TLC: DCMVMeOH 90V10 (Rf=0.38). Example 3 (ll-S , .21i?)-2 , -0-Acetyl-3-decIadinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11- f oxycarbonyl-(aminomethyl)-methylenel -erythromycin A To a solution of intermediate 4 (0.036g) in iPrOH (1.5mL), sodium cyanoborohydride (0.023g) and titanium(IH) chloride (10 wt.% solution in 20V30 wt.% hydrochloric acid, O.lmL) were added portionwise within 6h. The mixture was diluted with a saturated NaHC0 3 aqueous solution (3x2mL), exfracted with DCM (3x2mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH 100V0V0, 98V2V0, 95V5V0.5) to give the title compound (O.OlOg). Η-NMR (CDCI 3 ) δ: 5.06 (dd, IH), 4.76 (dd, IH), 4.38 (d, IH), 4.17 (d, IH), 3.80 (q, IH), 3.54 (bm, IH), 3.24 (m, IH), 3.20-3.00 (m, 4H), 2.64 (s, 3H), 2.60 (m, IH), 2.54 (m, IH), 2.25 (s, 1H+6H), 2.08 (s, 3H), 1.94 (m, IH), 1.74 (m, IH), 1.70-1.50 (m, 3H), 1.40 (d, 3H), 1.30 (m, IH), 1.30(s, 3H), 1.26 (d, 3H), 1.17 (d, 3H), 1.16 (d, 3H), 1.12 (d, 3H), 0.86 (t, 3H). Example 4 (HS'.21 J R. l )-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11- [oxycarbonyl-(benzhvdrylideneamino)-methyleneI-ervthromycin A To a solution of intermediate 18 (1.5g) and EDC (3.1g) in DCM (lOOmL) cooled to 0°C, DMSO (3.45mL) was added under nitrogen atmosphere. After stirring at 0°C for lOmin, a solution of pyridinium trifluoroacetate (3.12g) in anhydrous DCM (15mL) was slowly added. After lOmin the ice-bath was removed. The reaction mixture was stirred for 3h at room temperature then quenched with water (150mL) and extracted with DCM (3x250mL). The organic layer was dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (1.2g). 'H-NMR (CDCI 3 ) δ: 7.80-7.20 (m, 10H), 6.40 (dd, IH), 5.15 (s, IH), 4.73 (m, IH), 4.42 (d, IH), 4.16 (d, IH), 3.90 (q, IH), 3.55 (m, IH), 3.17 (m, IH), 2.95 (m, IH), 2.94 (d, IH), 2.67 (m, IH), 2.53 (s, 3H), 2.43 (m, IH), 2.33 (s, 6H), 2.05 (s, 3H), 2.00 (m, IH), 1.74 (m, IH), 1.65 (m, IH), 1.53 (s, 3H), 1.38 (d, 3H), 1.23 (s, 3H), 1.29 (d, 3H), 1.25 (m, IH), 1.25 (d, 3H), 1.14 (d, 3H), 1.07 (d, 3H), 0.83 (t, 3H). TLC: DCMVMeOH 10V1 (R-Ml.30). Example 5 (llS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl- (benzhydrylideneamino -methylenel -erythromycin A A solution of example 4 (0.030g) in MeOH (ImL) was stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.024g). 'H-NMR (CDC1 3 ) δ: 7.80-7.20 (m, 10H), 6.38 (dd, IH), 5.13 (s, IH), 4.34 (d, IH), 4.18 (d, IH), 3.91 (q, IH), 3.55 (m, IH), 3.20 (m, IH), 2.96 (m, IH), 2.63 (s, IH), 2.53 (s, IH), 2.44 (m, 2H), 2.26 (s, 6H), 2.00 (m, IH), 1.70-1.45 (m, 7H), 1.45 (d, IH), 1.30 (m, 4H), 1.04 (d, 3H), 0.96 (t, 3H), 0.91 (d, 3H). TLC: DCMVMeOH 10V1 (Rf=0.34). Example 6 (HS.21i?.S)-2 , -O-Acetyl-3-decladinosvI-ll-12-dideoxy-6-O-methyl-3-oxo-12.11- . oxycarbopyl-(amino)-methylenel -erythromycin A A solution of example 4 (l.lg) in acetonifrile (3 OmL) and a 1.2N HCl aqueous solution (70mL) was stirred at room temperature for lh. After neutralising the mixture with solid Na 2 C0 3 and evaporating the solvent, the aqueous phase was exfracted with DCM (3x200mL). The organic layer was dried over Na 2 S0 4 and concentrated under reduced pressure to give the title compound (0.9g). 1H-NMR (CDCI 3 ) δ: 5.45 (dd, IH), 4.75 (m, IH), 4.45 (d, IH), 4.40 (d, IH), 4.21 (d, IH), 3.82 (q, IH), 3.54 (m, IH), 3.09 (m, IH), 2.69 (m, IH), 2.68 (s, 3H), 2.58 (m, IH), 2.41(m, IH), 2.25 (s, 6H), 2.07 (m, 3H), 1.95 (m, IH), 1.75 (m, IH), 1.60 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.35 (m, IH), 1.31 (s, 3H), 1.26 (d, 3H), 1.17 (d+d, 6H), 1.09 (d, 3H), 0.88 (t, 3H). TLC: DCMVMeOH 10V1 (Rf=0.48). Example 7 (ll-S'.21S)-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12ai- f oxycarbonyl-(amino)-methylenel -erythromycin A To a solution of example 6 (15.1g) in anhydrous toluene (170mL) fresh distilled benzaldehyde (2.52mL) and pyridine (2.0 ImL) were added and the reaction mixture was refluxed for 4.5h. After evaporating the solvent the residue was dissolved in acetonifrile (60mL) then a 1.2N HCl aqueous solution (120mL) was added at room temperature. After stirring for 1.5h the solvent was evaporated and the aqueous acid solution exfracted with EtOAc (150mL) and DCM (150mL). The aqueous phase was neutralized with solid potassium carbonate and extracted with EtOAc (2xl50mL). The collected organic extracts were dried over Na 2 S0 and concentrated under reduced pressure to give the title compound (11.5g, 96%o pure by NMR analysis). 'H-NMR (CDCI 3 ) δ: 5.45 (dd, IH), 4.75 (m, IH), 4.45 (d, IH), 4.40 (d, IH), 4.21 (d, IH), 3.82 (q, IH), 3.54 (m, IH), 3.09 (m, IH), 2.69 (m, IH), 2.68 (s, 3H), 2.58 (m, IH), 2.41(m, IH), 2.25 (s, 6H), 2.07 (m, 3H), 1.95 (m, IH), 1.75 (m, IH), 1.60 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.35 (m, IH), 1.31 (s, 3H), 1.26 (d, 3H), 1.17 (d+d, 6H), 1.09 (d, 3H), 0.88 (t, 3H). Example 8 (ll-_»,21--*)-3-Decladinosyl-ll 2-dideoxy-6-0-methyl-3-oxo-12-ll-foxycarbonyl-(aminoV methylenel-ervthromvcin A A solution of example 7 (0.012g) in MeOH (ImL) was stirred at room temperature overnight. After evaporating the solvent under reduced pressure the crude material was purified by flash chromatography (eluting with: DCMVMeOH 100V5) to give the title compound (0.007g). 'H-NMR (CDCI 3 ) δ: 5.41 (dd, IH), 4.42 (d, IH), 4.33 (d, IH), 4.22 (d, IH), 3.83 (q, IH), 3.56 (m, IH), 3.23 (d, IH), 3.12 (m, IH), 3.02 (m, IH), 2.80 (d, IH), 2.69 (s, 3H), 2.60 (m, IH), 2.54 (m, IH), 2.40 (d, IH), 2.33 (s, 6H), 1.95 (m, IH), 1.9-1.50 (m, 3H), 1.49 (s, 3H), 1.39 (d, 3H), 1.35 (m, IH), 1.33 (s, 3H), 1.32 (m, IH), 1.31 (d, 3H), 1.26 (d, 3H), 1.16(d, 3H), 1.10 (d, 3H), 0.88 (t, 3H). Example 9 (10-R.S.ll,R)-3-DecladinosvI-li 2-dideoxy-6-O-methyl-3-oxo-12αi- foxycarbonylmethylenel-ervthromycin A To a solution of intermediate 23 (0.050g) in anhydrous DCM (25mL), EDC (0.102g) and DMSO (0.115mL) were added under nitrogen atmosphere. The mixture was cooled to 0°C and a solution of pyridinium trifluoroacetate (0.102g) in DCM (0.5mL) was added dropwise. The mixture was allowed to reach room temperature; after stirring for 5h water (lOmL) was added and the mixture exfracted with DCM (2x20mL). The organic phase was dried over Na 2 S0 4 , concentrated under reduced pressure and the crude material purified by preparative TLC (eluting with: DCMVMeOH 95V5). The recovered silica gel was stirred for 18h in MeOH (2mL), the mixture was filtered and solvent evaporation under reduced pressure gave the title compound (0.025g). 'H-NMR (CDCI 3 ) δ: 4.90 (dd, IH), 4.32 (d, IH), 4.24 (d, IH), 3.85 (q, IH), 3.56 (m, IH), 3.32 (d, IH), 3.18 (m, IH), 3,12 (m, IH), 3.02 (m, IH), 2.80 (d, IH), 2.71 (dd, IH), 2.63 (s, 3H), 2.55 (m, IH), 2.47 (m, IH), 2.27 (s, 6H), 1.87 (m, IH), 1.70 (m, IH), 1.62 (m, IH), 1.58 (m, IH), 1.50 (s, 3H), 1.38 (d, 3H), 1.30 (d, 3H), 1.31 (s, 3H), 1.30 (m, IH), 1.25 (d, 3H), 1.22 (m, IH), 1.14 (d, 3H), 1.07 (d, 3H), 0.86 (t, 3H). Example 10 (llS.21S)-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-2-fluoro-6-0-methyl-3-oxo-12,ll- .oxycarbonyl-(amino)-methylene1-ervthromycin A To a solution of example 7 (0.284g) in anhydrous THF (14mL) cooled to -10°C potassium tert-butoxide (IM in THF, 0.553mL) was added under nifrogen atmosphere. After 5min N- fluorobenzenesulfonimide (0.148g) was added at -10°C. The mixture was stirred at room temperature for lh. The reaction mixture was diluted with DCM (15mL) and washed with water (15mL). The organic layer was dried over Νa 2 S0 4 and concentrated under vacuum. The crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from 100V0V0, to 94V6V0.2) to give the title compound (0.120g). mVz ([MH] + ) = 687. 'H-NMR (CDCI3) δ: 5.35 (dd, IH), 4.74 (M, IH), 4.48 (d, IH), 4.33 (d, IH), 3.96 (m, IH), 3.52 (m, IH), 2.89 (s, 3H), 2.86 (m, IH), 2.72 (m, IH), 2.53 (m, IH), 2.27 (s, 6H), 2.08 (s, 3H), 2.0-1.94 (m, 2H), 1.82 (d, 3H), 1.76 (m, IH), 1.64 (m, IH), 1.48 (d+m, 3H+1H), 1.31 (s, 3H , 1.26 (m, 6H), 1.16 (d, 3H), 1.08 (d, 3H), 0.92 (t, 3H). Example 11 (llS,21S)-3-DecIadinosyl-ll,12-dideoxy-2-fluoro-6-O-methyl-3-oxo-12Jl-roxycarbonyl- (amino)-methylenel -erythromycin A A solution of example 10 (O.OlOg) in MeOH (ImL) was stirred at room temperature overnight. Evaporation of the solvent under reduced pressure gave the title compound (0.005g). 'H-NMR (CDC1 3 ) δ: 5.33 (dd, IH), 4.42 (d, IH), 4.33 (d, IH), 4.03 (dd, IH), 3.53 (bm, IH), 3.18 (m, IH), 3.10 (m, IH), 2.93 (s, 3H), 2.90 (m, IH), 2.54 (m, 2H), 2.30 (s, 6H), 2.09 (s, IH), 2.06 (m, IH), 1.96 (m, IH), 1.82 (d, IH), 1.62-1.50 (m, 6H), 1.34 (s, 3H), 1.27(m, 4H), 1.26 (s, 3H), 1.16 (d, 3H), 1.08 (d, 3H), 0.92 (t, 3H). Example 12 fllS.21S)-3-DecIadinosyl-llΛ2-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-(2-fN-t- butylcarbamate)-ethylamino)-methylene] -erythromycin A To a solution of example 7 (1.34g) in anhydrous acetonifrile (12mL) tert-butyl N-(2- oxoethyl)carbamate (0.640g) was added under nitrogen atmosphere and the resulting mixture was stirred for 24h at room temperature. Sodium cyanoborohydride (IM in THF, 2.0mL) and acetic acid (0.114mL) were added and the reaction mixture was stirred for 12h at room temperature. After evaporating the solvent, the residue was dissolved in DCM (lOOmL) and washed with a saturated ΝaHC0 3 aqueous solution (50mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The residue was diluted in MeOH (35mL) and refluxed for 15 h. The solvent was evaporated under reduced pressure and the crude material purified by flash chromatography (eluting with: cyclohexaneVacetone 85V15) to give the title compound (1.51g, % pure by NMR analysis). mVz ([MH] + ) = 770. Example 13 rilS.21S)-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-methvI-3-oxo-12,ll- foxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A To a solution of example 11 (1.5g) in anhydrous DCM (5.4mL) trifluoroacetic acid (0.6mL) was added under nifrogen atmosphere and the resulting mixture was stirred for 2h at room temperature. The reaction mixture was diluted with EtOAc (15mL) and concenfrated under reduced pressure. The residue was dissolved in DCM (lOOmL) and washed with a saturated NaHC0 3 aqueous solution (50mL), dried over Na 2 S0 and concenfrated under reduced pressure to give the title compound (1.05g). mVz ([MH] + ) = 670. 'H-NMR (CDCI 3 ) δ: 5.12 (dd, IH), 4.32 (d, IH), 4.21 (d, IH), 4.05 (m, IH), 3.85 (q, IH), 3.58 (m, IH), 3.25 (dd, IH), 3.20-3.0 (m, 4H), 3.05 (m, 2H), 2.67 (m, IH), 2.68 (s, 3H), 2.61 (m, IH), 2.40 (s, 6H), 2.32 (m, IH), 1.91 (m, IH), 1.78-1.68 (m, 3H), 1.60 (m, IH), 1.47 (s, 3H), 1.38 (d, 3H), 1.32 (s, 3H), 1.30 (d, 3H), 1.29 (m, IH), 1.27 (d, 3H), 1.15 (d, 3H), 1.11 (d, 3H), 0.88 (t, 3H). Example 14 (llS.21_g)-2 , -O-Acetyl-3-decladiposyl-ll,12-dideoxy-6-Q-methvI-3-oxo-12Jl- foxycarbonyl-(3-quinoIinyl-carbonylaminomethyl)-methylenel-ervthromycin A To a solution of intermediate 25 (0.035g) in anhydrous DCM (1.5mL), EDC (0.041g) and DMSO (0.04 ImL) were added at 0°C under nitrogen atmosphere. After stirring at 0°C for 15min, pyridinium frifluoroacetate (0.042g) was added. The reaction mixture was stirred for 3h at room temperature, then quenched with water (3mL) and extracted with DCM (5mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by preparative TLC (eluting with: DCMVMeOH 95V5) to give the title compound (0.016g). mVz ([MH] + ) = 838. Example 15 (ll--f.21-R)-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-(3- quinolinyl-carbonylaminomethvD-methylenel-ervthromvcin A A solution of example 14 (0.016g) in MeOH (1.5mL) was stirred for 24h then concentrated under reduced pressure to give the title compound (0.009g). 'H-NMR (CDC1 3 ) δ: 9.50 (d, IH), 8.79 (d, IH), 8.16 (d, IH), 7.94 (d, IH), 7.84 (t, NH), 7.81 (t, IH), 7.61 (t, IH), 4.90 (dd, IH), 4.27 (d, IH), 4.19 (d, IH), 4.01 (m, 2H), 3.84 (d, IH), 3.52 (m, 3H), 3.14 (m, 3H), 2.70 (m, IH), 2.53 (s, 3H), 2.54 (m, IH), 2.43 (m, IH), 2.27 (s, 6H), 1.95 (m, IH), 1.84 (d, IH), 1.75 (m, IH), 1.64 (m, IH), 1.60 (m, IH), 1.56 (s, 3H), 1.38 (d, 3H), 1.30 (d, 3H), 1.26 (s, 3H), 1.22 (m, IH), 1.22 (d, 3x3H), 0.88 (t, 3H). Example 16 (ll-_-'.21i?V2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12.11- foxycarbonyl-f4-(4-(pyridin-3-yl)-imidazol-l-vI)-bptyramidomethyl)-methylenel- erythromycin A To a solution of intermediate 26 (0.040g) in anhydrous DCM (3mL) Dess-Martin periodinane (0.030g) was added portionwise at room temperature within 5h. The reaction was quenched with a Na 2 S 2 0 3 solution (5% in a saturated NaHC0 3 aqueous solution, 2mL), stirred for lh then extracted with DCM (lOmL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.029g). TLC: DCMVMeOH 90V10 (Rf=0.42). Example 17 (llS.21-RV3-Decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12.11-roxycarbonyl-(4-(4- (pyridin-3-yl)-imidazol-l-yl)-butyramidomethyl)-methylenel-ervthromycin A A solution of example 16 (0.029g) in MeOH (2mL) was stirred for 24h then concenfrated under reduced pressure to give the title compound (0.023g). 'H-NMR (CDC1 3 ) δ: 8.98 (d, IH), 8.40 (dd, IH), 8.10 (dd, IH), 7.61 (d, IH), 7.35 (d, IH), 7.29 (m, IH), 6.48 (t, NH), 4.89 (dd, IH), 4.30 (d, 2H), 4.21 (d, IH), 4.01 (m, IH), 3.83 (q, IH), 3.73 (m, IH), 3.55 (m, IH), 3.34 (m, IH), 3.19 (m, IH), 3.08 (m, 2H), 2.65 (s, 3H), 2.58 (m, IH), 2.47 (m, IH), 2.34 (m, IH), 2.28 (s, 6H), 2.3-2.1 (m, 4H), 1.91 (m, IH), 1.81 (m, IH), 1.80-1.54 ( , 3H), 1.51 (s, 3H), 1.39 (d, 3H), 1.35 (m, IH), 1.32 (s, 3H), 1.30 (d, 3H), 1.25 (d, 3H), 1.12 (d, 3H), 1.15(d, 3H), 1.12 (d, 3H), 0.87 (t, 3H). Example 18 (ll-S'.21ig)-2 , -O-Acetyl-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11- foxycarbonyl-(3-(4-(pyridin-3-yl)-imidazol-l-yl)-propionamidomethyl)-methylenel- ervthromvcin A To a solution of intermediate 27 (0.039g) in anhydrous DCM (3mL) under nitrogen atmosphere Dess Martin periodinane (0.030g) was added portionwise at room temperature within 5h. The reaction was quenched with a Na 2 S 2 0 3 solution (5% in a saturated NaHC0 3 aqueous solution, 7mL), stirred for lh and then extracted with DCM (15mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.026g). TLC: DCMVMeOH 90V10 (Rf=0.35). Example 19 (llS.21RV3-Decladinosyl-ll 2-dideoxy-6-O-methyl-3-oxo-12 l-[oxycarbonyl- (3-(4-(pyridin-3-yl)-imidazol-l-yl -propionamidomet--tyl -methylenel- erythromycin A A solution of example 18 (0.024g) in MeOH (ImL) was stirred for 24h then concentrated under reduced pressure to give the title compound (0.020g). 'H-NMR (CDCI 3 ) δ: 8.99 (d, IH), 8.45 (dd, IH), 8.08 (dd, IH), 7.58 (d, IH), 7.35 (d, IH), 7.29 (m, IH), 6.67 (t, NH), 4.80 (dd, IH), 4.36 (m, 2H), 4.30 (d, IH), 4.19 (d, IH), 3.83 (m, 2H), 3.61 (m, IH), 3.55 (m, IH), 3.25 (m, 2H), 3.04 (m, 2H), 2.70 (m, 2H), 2.62 (s, 3H), 2.58 (m, 2H), 2.33 (s, 6H), 2.32 (d, IH), 1.85 (m, IH), 1.80 (m, IH), 1.70 (m, 2H), 1.56 (m, IH), 1.48 (s, 3H), 1.45 (d, 3H), 1.33 (s, 3H), 1.21 (d, 3H), 1.35 (m, IH), 1.18 (d, 3H), 1.04 (d, 3H), 0.95 (t, 3H), 0.91 (d, 3H). Example 20 (11 '.21Jg)-3-DecladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12Jl-foxycarbonvI-r2-f4- (pyridin-3-yl " )-imidazol-l-yl -acetamidomethyl)-methylenel-ervthromvcin A To a solution of intermediate 28 (0.018g) in anhydrous DCM (1.5mL) under nitrogen atmosphere Dess-Martin periodinane (0.020g) was added portionwise at room temperature within 5h. The reaction was quenched with a Na 2 S 2 0 3 solution (5% in a saturated NaHC0 3 aqueous solution, 2mL), stirred for lh then exfracted with DCM (lOmL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by preparative TLC (eluting with: DCMVMeOH 10V1) and the recovered silica gel was stirred overnight in MeOH (ImL). The mixture was filtered and solvent evaporation under reduced pressure gave the title compound (0.009g). 'H-NMR (CDC1 3 ) δ: 9.02 (d, IH), 8.49 (m, IH), 8.11 (m, IH), 7.65 (d, IH), 7.43 (d, IH), 7.30 (m, IH), 6.58 (t, NH), 4.89 (dd, IH), 4.70 (dd, 2H), 4.29 (d, IH), 4.20 (d, IH), 3.83 (m, 2H), 3.69 (m, IH), 3.51 (m, IH), 3.29 (m, IH), 3.17 (m, IH), 3.04 (m, 2H), 2.60 (s, 3H), 2.54 (m, IH), 2.44 (m, IH), 2.31 (m, IH), 2.27 (s, 6H), 1.91 (m, IH), 1.80 (m, IH), 1.68 (m, 2H), 1.60 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.29 (s, 3H), 1.29 (d, 3H), 1.22 (m, IH), 1.25 (d, 3H), 1.12 (d, 3H), 1.10 (d, 3H), 0.87 (t, 3H). Example 21 (ll-y,21 J _?)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbo---yl-(l- (pyrrolidin-2-one)- methvD-methylenel -erythromycin A To a solution of intermediate 29 (0.020g) in anhydrous DCM (2mL) under nitrogen atmosphere Dess-Martin periodinane (0.017g) was added portionwise at room temperature within lh. After stirring for 5h the reaction was quenched with a solution Na 2 S 2 0 3 (5% in a saturated NaHC0 3 aqueous solution, 2mL), stirred for lh then exfracted with DCM (3 5mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 95V5) to give a compound that was dissolved in MeOH (2mL) and stirred at room temperature overnight. Evaporation of the solvent gave the title compound (O.OlOg). 'H-NMR (CDCI 3 ) δ: 4.39 (m, IH), 3.76 ( , IH), 3.52 (m, IH), 3.39 (m, IH), 3.15 (m, IH), 3.04 (m, IH), 2.41 (m, IH), 2.36 (m, IH), 2.32 (m, IH), 2.10 (m, IH), 2.02 ( , IH), 1.12 (d, 3H). Example 22 (llS,21ϋr -3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(2- (quinoxalin-2-ylsulfanyl)-acetamidomethyl)-methylenel-erythromvcin A To a solution of intermediate 30 (0.068g) in anhydrous DCM (5mL) Dess-Martin periodinane (0.064g) was added under nitrogen atmosphere. The mixture was stirred at room temperature for 6h. The reaction was quenched with a solution Na 2 S 2 0 3 (5% in a saturated NaHC0 3 aqueous solution, 5mL), stirred for 30min and then extracted with DCM (3x4mL). The organic phase was washed with brine (5mL), dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was dissolved in MeOH (5mL) and stirred overnight. Solvent evaporation under reduced pressure gave the title compound (0.053g). 'H-NMR (CDCI 3 ) δ: 8.70 (s, IH), 8.05 (d, IH), 8.02 (d, IH), 7.71 (td, IH), 7.64 (td, IH), 7.59 (bt, IH), 4.11 (d, IH), 4.03 (m, IH), 3.34 (bm, IH), 2.98 (m, IH), 1.01 (d, 3H). Example 23 (llS , .21-g)-3-Decladinosyl-ll,12-dideoxy-6-0-methvI-3-oxo-12,ll-foxycarbonyI-(3- (quinoxalin-2-ylsulfanyl -propionamidomethyl)-methylenel-erythromvcin A To a solution of intermediate 31 (0.035g) in anhydrous DCM (2.5mL) Dess-Martin periodinane (0.033g) was added under nifrogen atmosphere. The mixture was stirred at room temperature for 18h. The reaction was quenched with a Na 2 S 2 0 3 solution (5% in a saturated NaHC0 3 aqueous solution, 2mL), stirred for 30min and then exfracted with DCM (3x4mL). The organic phase was washed with brine (3mL), dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was dissolved in anhydrous MeOH (2mL) and stirred overnight. The solvent was evaporated under reduced pressure and the crude material purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 95V5) to give the title compound (0.01 lg). 'H-NMR (CDC1 3 ) δ: 8.50 (s, IH), 8.00 (d, IH), 7.98 (d, IH), 7.70 (t, IH), 7.61 (t, IH), 6.69 (bt, IH), 3.83 (m, IH), 3.68 (m, IH), 3.64 (m, IH), 3.34 (m, IH), 3.06 (m, IH), 2.77 (m, IH), 2.34 (m, IH), 1.11 (d, 3H). Example 24 (1 l-S.21-R -3-Decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l 1- [oxycarbonyl- f(quinolin-4-vImethylene)-aminol-methyl)-methylenel-ervthromvcin A To a solution of intermediate 32 (O.lOOg) in anhydrous DCM (4mL) Dess Martin periodinane (0.1 lOg) was added portionwise within 3h under nifrogen atmosphere. The mixture was stirred at room temperature for 3h. The reaction was quenched with a Na 2 S 2 0 3 solution (5% in a saturated NaHC0 3 aqueous solution, 2mL), stirred for 45min and then exfracted with DCM (3x4mL). The organic phase was washed with brine (3mL), dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by preparative TLC (eluting with: DCMVMeOH 95V5), the recovered silica gel stirred for 18h in MeOH (5mL), the mixture filtered and then solvent evaporation under reduced pressure gave the title compound (0.015g). mVz ([MRΫ) = 780. Example 25 (llS.21-R)-3-Decladinosyl-ll,12-dideoxy-6-Q-methyl-3-oxo-12,ll-roxycarbonyl- [(quinoIin-4-vImethyl)-aminol-methyl)-methylene1-erythromvcin A To a solution of example 24 (0.015 g) in anhydrous MeOH (6mL) palladium (lOwt. % on carbon powder, 0.005g) was added and the mixture stirred under hydrogen atmosphere (6 atm) for 20h. Filfration through a celite pad eluting with MeOH (20mL) and purification by flash chromatography (eluting with DCMVMeOH from 100V0 to 95V5) and by preparative TLC (eluting with: DCMVMeOHVNH 4 OH 87.5V12.5V0.5) gave the title compound (0.002g). 'H-NMR (CDCI3) δ: 8.87 (d, IH), 8.10 (d, 2H), 7.61 (d, IH), 7.70 (m, IH), 7.57 (m, IH), 4.38 (d, IH), 4.26 (d, IH), 3.55 (m, IH), 3.28÷3.00 (m, 2H). Example 26 ril_y.21_g.-y)-3-Pecladinosyl-liα2-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-r3-f4- (pyridin-3-yl)-imidazol-l-yl)-propionamido)-methylenel-ervthromycin A To a solution of example 6 (0.020g) in anhydrous DMF (2mL) under nifrogen atmosphere intermediate 48 (0.009g), HATU (0.013g) and DIPEA (0.013mL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (15mL) and washed with water (lOmL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give a compound that was dissolved in MeOH (ImL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.009g). 'H-NMR (CDC1 3 ) δ: 9.04 (d, IH), 8.44 (dd, IH), 8.13 (m, IH), 7.61 (m, IH), 7.41 (d, IH), 6.73 (bd, IH), 5.08 (dd, IH), 4.94 (m, IH), 4.45 (m, IH), 4.26 (m, IH), 4.25 (d, IH), 4.08 (m, 3H), 3.80 (q, IH), 3.51 (m, IH), 3.15 (m, IH), 3.04 (m, IH), 2.98 (m, IH), 2.65 (m, IH), 2.60 (m, IH), 2.52 (m, IH), 2.44 (m, IH), 2.39 (s, 3H), 2.34 (m, IH), 2.26 (s, 6H), 1.90 (m, IH), 1.75 (m, IH), 1.65-1.55 (m, 3H), 1.48 (s, 3H), 1.37 (d, 3H), 1.27 (d, 3H), 1.22 (d, 3H), 1.25 (m, IH), 1.17 (s, 3H), 1.16 (d, 3H), 1.12 (d, 3H), 0.87 (t, 3H). Example 27 (llS,21_g)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl-(4-(4- (pyridin-3-yl)-imidazol-l-yl -butyramido -methylenel-ervthromvcin A and Example 28 (llS.21S)-3-Decladinosyl-liα2-dideoxy-6-Q-methyl-3-oxo-12,ll-foxycarbonyl-(4-f4- (pyridin-3-yl)-imidazol-l-yl)-butyramido)-methylenel-ervthromvcin A To a solution of example 6 (0.020g) in anhydrous DMF (2mL) under nifrogen atmosphere intermediate 49 (0.009g), HATU (0.013g) and DIPEA (0.013mL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (15mL) and washed with water (lOmL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5, 90V10) and the (21R and (21S) isomers were isolated. Each isomer was dissolved in MeOH (ImL) and stirred at room temperature overnight. Evaporation of the solvent under reduced pressure gave the title compound 27 (0.003g) and the title compound 28 (0.006g). H-NMR (CDCI 3 ) δ(example 27): 8.98 (d, IH), 8.89 (bd, IH), 8.46 (d, IH), 8.08 (d, IH), 7.61 (d, IH), 7.41 (d, IH), 7.28 (m, IH), 5.33 (dd, IH), 5.22 (dd, IH), 4.31 (d, IH), 4.25 (d, IH), 4.14 (m, 2H), 3.88 (q, IH), 3.56 (m, IH), 3.27 (m, IH), 3.17 (dd, IH), 3.06 (m, IH), 2.99 (m, IH), 2.66 (m, IH), 2.57 (s, 3H), 2.46 (m, IH), 2.40 (m, 2H), 2.27 (s, 6H), 2.21 (m, 2H), 1.86 (m, IH), 1.84 ( , IH), 1.70-1.50 (m, 3H), 1.54 (s, 3H), 1.36 (d, 3H), 1.33 (d, 3H), 1.29 (s, 3H), 1.25 (m, IH), 1.24 (d, 3H), 1.17 (d, 3H), 1.08 (d, 3H), 0.90 (t, 3H). 'H-NMR (CDCI 3 ) δ (example 28): 9.02 (d, IH), 8.46 (dd, IH), 8.11 (m, IH), 7.61 (m, IH), 7.37 (d, IH), 7.31 (m, IH), 6.47 (bd, IH), 5.26 (dd, IH), 4.81 (bt, IH), 4.29 (d, IH), 4.13 (m, 3H), 3.81 (q, IH), 3.54 (m, IH), 3.17 (m, IH), 3.08-3.04 (m, 2H), 2.53 (s, 3H), 2.56 (m, IH), 2.45 (m, IH), 2.36 (m, IH), 2.27 (s, 6H), 2.17-2.13 (m, 4H), 2.00 (m, IH), 1.80 (m, IH), 1.68 (m, IH), 1.60 (m, IH), 1.51 (s, 3H), 1.40 (d, 3H), 1.29 (s, 3H), 1.30 (d, 3H), 1.25 (m, IH), 1.22 (d, 3H), 1.19 (d, 3H), 1.16 (d, 3H), 0.91 (t, 3H). Example 29 (llS.21i-.5^-3-Decladinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-(5-(4- (pyridin-3-yl)-imidazoI-l-yl)-pentylamido)-methylene1-ervthromycin A To a solution of example 6 (O.lOOg) in anhydrous DMF (5mL) under nifrogen atmosphere intermediate 50 (0.048g), HATU (0.063 g) and DIPEA (0.06 ImL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (3 OmL) and washed with water (25mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5, 90V10) to give a compound that was dissolved in MeOH (5mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.090g). 'H-NMR (CDC1 3 ) δ: 8.98 (d, IH), 8.45 (d, IH), 8.09 (d, IH), 7.55 (s, IH), 7.34 (s, IH), 7.29 (m, IH), 6.45 (bd, IH), 5.19 (dd, IH), 4.82 (m, IH), 4.29 (d, IH), 4.12 (d, IH), 3.98 (m, 2H), 3.80 (q, IH), 3.55 (m, IH), 3.17 (m, IH), 3.06 (m, 2H), 2.55 (s+m, IH + 3H), 2.45 (m, IH), 2.35 (m, IH), 2.27 (s, 6H), 2.21 (m, 2H), 1.98 (m, IH), 1.88 (m, 2H), 1.80 (m, 2H), 1.60-1.50 (m, 3H), 1.49 (s, 3H), 1.39 (d, 3H), 1.35 (m, IH), 1.30 (d+s, 3H+3H), 1.23 (d, 3H), 1.16 (d, 3H+3H), 0.89 (t, 3H). Example 30 (llS,21R)-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12αi- Ioxycarbonyl-(2-(4-(pyridin-3-yl)-imidazol-l-yl)-acetamido -methylenel-ervthromvcin A and Example 31 (HS'.21S)-2 , -O-Acetyl-3-decIadiposyl-liα2-dideoxy-6-O-methyl-3-oxo-12.11- foxycarbonyl-(2-(4-(pyridin-3-yl)-imidazol-l-yl -acetamido)-methylenel-ervthromvcin A To a solution of example 6 (O.lOOg) in anhydrous DMF (8mL) under nifrogen atmosphere a solution of intermediate 47 (0.040g) in anhydrous DMF (2mL), HATU (0.057g) and DIPEA (O.OδOmL) were sequentially added. The mixture was stirred at room temperature for 8h. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (3 OmL) and washed with water (2x1 OmL). The aqueous phase was extracted again with DCM (20mL). The organic layers were collected, dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 95V5 to 92V8) to give the title compound 30 (0.008g) and the title compound 31 (0.021g). TLC: DCMVMeOH 95V5 (Rf (example 30) = 0.53) TLC: DCMVMeOH 95V5 (Rf (example 31) = 0.47). Example 32 (ll-S , .21R -3-Decladinosyl-llJ2-dideoxy-6-O-methvI-3-oxo-12,ll-roxycarbonvI-(2-(4- (pyridin-3-yl)-imidazol-l-yl)-acetamido)-methylenel-ervthromvcin A A solution of example 30 (0.007g) in MeOH (5mL) was stirred at room temperature for 48h. After evaporating the solvent under reduced pressure, the crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 80V20) to give the title compound (0.003g). 'H-NMR (CDC1 3 ) δ: 9.19 (d, IH), 8.98 (d, IH), 8.47 (dd, IH), 8.06 (d, IH), 7.70 (d, IH), 7.42 (d, IH), 7.29 (m, IH), 5.24 (d, IH), 4.80 (dd, IH), 3.18 (m, IH), 2.94 (d, IH), 0.99 (d, 3H). Example 33 (llS.21S.-3-Decladinosyl-llJ2-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-f2-(4- (pyridin-3-yl)-imidazol-l-vI)-acetamido)-methylenel-ervthromycin A A solution of example 31 (0.021g) in MeOH (5mL) was stirred at room temperature for 48h. After evaporating the solvent under reduced pressure, the crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 80V20) to give the title compound (0.006g). 'H-NMR (CDCI 3 ) δ: 8.99 (d, IH), 8.47 (d, IH), 8.09 (d, IH), 7.58 (s, IH), 7.41 (s, IH), 7.30 (m, IH), 6.73 (d, IH), 4.88 (dd, IH), 4.67 (s, IH), 3.08 (m, IH), 2.41 (d, IH), 1.16 (d, 3H). Example 34 (ll-y.21-y)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl- ((quinolin-4-yl carbonylamino -methylenel-erythromvcin A To a solution of example 6 (O.lOOg) in anhydrous DMF (8mL) under nifrogen atmosphere a solution of quinoline-4-carboxylic acid (0.026g) in anhydrous DMF (2mL), HATU (0.057g) and DIPEA (0.060mL) were added. The mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (3 OmL) and washed with a saturated NaHC0 3 aqueous solution (2x1 OmL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 94V6). The obtained compound was dissolved in MeOH (lOmL) and stirred overnight. After solvent evaporation, purification by flash chromatography (eluting with: DCMVMeOH 90V10) gave the title compound (0.032g). 'H-NMR (CDCI3) δ: 8.96 (d, IH), 8.45 (d, IH), 8.13 (d, IH), 7.76 (t, IH), 7.65 (t, IH), 7.52 (d, IH), 7.02 (d, IH), 5.08 (dd, IH), 3.17 (m, IH), 2.60 (m, IH), 1.28 (d, 3H). Example 35 (ll_-».21S.-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(3- (quinolin-4-yl)-propionamido)-methylenel -erythromycin A To a solution of example 6 (O.lOOg) in anhydrous DMF (8mL) under nitrogen atmosphere 3- quinolin-4-yl-propionic acid (0.030g), HATU (0.057g) and DIPEA (0.060mL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (30mL) and washed with water (25mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 94V6) to give a compound that was dissolved in MeOH (2mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.022g). 'H-NMR (CDC1 3 ) δ: 8.82 (d, IH), 8.10 (d, IH), 8.07 (d, IH), 7.71 (t, IH), 7.61 (t, IH), 7.26 (d, IH), 6.50 (bd, IH), 5.14 (dd, IH), 4.92 (dd, IH), 4.28 (d, IH), 4.12 (d, IH), 3.80 (q, IH), 3.54 (m, IH), 3.46 (m, 2H), 3.16 (m, IH), 3.08 (m, IH), 3.04 (m, IH), 2.60 (m, 2H), 2.49 (s, 3H), 2.45 (m, IH), 2.39 (m, IH), 2.26 (s, 6H), 2.00 (m, IH), 1.80 (m, 2H), 1.72 (m, IH), 1.65 (m, IH), 1.60 (m, IH), 1.50 (s, 3H), 1.39 (d, 3H), 1.29 (d, 3H), 1.28 (s, 3H), 1.25 (m, IH), 1.24 (d, 3H), 1.18 (d, 3H), 1.14 (d, 3H), 0.91 (t, 3H). Example 36 i-S l .21S)-3-Decladinosyl-m2-dideoxy-6-Q-methyl-3-oxo-12,ll-roxycarbonvI-(4- (quinolin-4-yl)-butyramido)-methylenel -erythromycin A To a solution of example 6 (0.075g) in anhydrous DMF (6mL) under nifrogen atmosphere intermediate 60 (0.027g), HATU (0.043g) and DIPEA (0.047mL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (20mL) and washed with a saturated NaHC0 3 aqueous solution (15mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 97V3 to 95V5) to give a compound that was dissolved in MeOH (2mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.039g). 'H-NMR (CDCI 3 ) δ: 8.81 (d, IH), 8.11 (d, IH), 8.09 (d, IH), 7.69 (t, IH), 7.58 (t, IH), 7.26 (m, IH), 6.47 (bd, IH), 5.20 (dd, IH), 4.88 (dd, IH), 4.30 (d, IH), 4.13 (s, IH), 4.13 (m, 2H), 3.80 (q, IH), 3.53 (m, IH), 3.19-3.00 (m, 5H), 2.54 (s, 3H), 2.61-2.41 (m, 3H), 2.29 (s+m, 2H+ 6H), 2.11 (m, 2H), 2.00 (m, IH), 1.80-1.60 (m, 7H), 1.39 (d, 3H), 1.29 (s+d, 3H+3H), 1.24 (m, 4H), 1.18 (d, 3H), 1.14 (d, 3H), 0.91 (t, 3H). Example 37 (H_y.21R._?.-3-DecladinosvI-llJ2-dideoxy-6-0-methyl-3-oxo-12αi-roxycarbonyl-(5- (quinolin-4-yl)-pentylamido)-methylenel-ervthromycin A To a solution of example 6 (O.lOOg) in anhydrous DMF (6mL) under nifrogen atmosphere intermediate 62 (0.027g), HATU (0.057g) and DIPEA (0.057mL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (20mL) and washed with water (15 L). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give a compound that was dissolved in MeOH (2mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.024g). 1H-NMR (CDCI 3 ) δ: 8.81 (d, IH), 8.11 (d, IH), 8.04 (m, IH), 7.70 (m, IH), 7.58 (m, IH), 7.27 (m, IH), 6.42 (bd, IH), 5.18 (dd, IH), 4.85 (dd, IH), 4.30 (m, IH), 4.13 (m, IH), 3.79 (q, IH), 3.54 (m, IH), 3.17 (m, IH), 3.08 (m, 4H), 2.58 (m, IH), 2.55 (s, 3H), 2.45 (m, IH), 2.40 (m, IH), 2.27 (s, 6H), 2.23 (m, 2H), 1.98 (m, IH), 1.81 (m, 4H), 1.75 (m, IH), 1.70 (m, IH), 1.65 (m, IH), 1.60 (m, IH), 1.50 (s, 3H), 1.40 (d, 3H), 1.30 (d, 3H), 1.28 (s, 3H), 1.24 (d, 3H), 1.20 (m, IH), 1.18 (d, 3H), 1.14 (d, 3H), 0.89 (t, 3H). Example 38 (1 lS.21R^_>)-3-DecIadinosyl-l l,12-dideoxy-6-O-methyl-3-oxo-12.11- foxycarbonvI-(3-(4- phenyl-imidazol-l-yl)-propionamido)-methylenel-ervthromvcin A To a solution of example 7 (0.050g) in anhydrous DMF (4mL) under nitrogen atmosphere a solution of intermediate 65 (0.018g) in anhydrous DMF (ImL), HATU (0.013g) and DIPEA (0.013mL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (15mL) and washed with a saturated NaHC0 3 aqueous solution (lOmL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 94V6) to give a compound that was dissolved in MeOH (2mL) and stirred at room temperature overnight. Evaporation of the solvent under reduced pressure gave the title compound (0.03 lg). 'H-NMR (CDCI 3 ) δ: 7.78 (d, 2H), 7.47 (d, IH), 7.31 (t, 2H), 7.27 (d, IH), 7.16 (t, IH), 6.64 (d, IH), 5.04 (dd, IH), 4.99 (m, IH), 4.20 (m, IH), 3.01 (m, IH), 2.60-2.50 (m, 2H), 2.33 (dd, IH), 1.12 (d, 3H). Example 39 (lliS l .21R-S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-foxycarbonyl-(2-(4- phenyl-imidazol-l-ylVacetamidoVmethylenel-ervthromvcin A To a suspension of intermediate 67 (0.022g) in anhydrous DMF (1.6mL) HATU (0.037g) and DIPEA (0.015mL) were sequentially added. The mixture was stirred under nifrogen atmosphere for 30min then example 7 (0.050g) was added. After stirring at room temperature overnight the reaction mixture was diluted with DCM (3.5mL), washed with a 5% NaHC0 3 aqueous solution (3mL) while ice-cooling and the aqueous phase extracted with DCM (2.5mL). The collected organic extracts were dried over Na 2 S0 4 and concenfrated under reduced pressure. The residue was dissolved in MeOH (lOmL) and stirred at room temperature overnight. After solvent evaporation under reduced pressure the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from lOOVOVO to 94V6V0.5) to give the title compound (O.OlOg). 1H-NMR (DMSO) δ: 8.62 (d, IH), 7.71 (d, 2H), 7.58 (d, IH), 7.49 (d, IH), 7.33 (t, 2H), 7.17 (t, IH), 4.69 (d, IH), 4.62 (d, IH), 4.59 (d, IH), 3.19 (m, IH), 2.59 (m, IH), 1.10 (d, 3H). Example 40 (llS.2-?R.S l .-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12Jl-roxycarbonyl-(3-(4- thiophen-2-vI-i__-udazol-l-vI)-propionamido -methylene1-ervthromvcin A To a solution of example 7 (0.034g) in anhydrous DMF (4mL) under nitrogen atmosphere a solution of intermediate 69 (0.012g) in anhydrous DMF (ImL), HATU (0.019g) and DIPEA (0.020mL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (lOmL) and washed with a saturated NaHC0 3 aqueous solution (5mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 94V6) to give a compound that was dissolved in MeOH (5mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.020g). 'H-NMR (CDC1 3 ) δ: 7.46 (d, IH), 7.31 (dd, IH), 7.20 (d, IH), 7.14 (dd, IH), 7.00 (dd, IH), 6.68 (d, IH), 5.08 (dd, IH), 4.40 (m, IH), 4.20 (m, IH), 3.05 (m, IH), 2.68 (m, IH), 2.50 (ro, lH), 2.38 (dd, IH), 1.16 (d, 3H). Example 41 rilS.21-R-S)-3-DecIadinosyl-li 2-dideoxy-6-O-methyl-3-oxo-12.11-foxycarbonyl-(3-f3- (l,3-thiazol-2-yl)-lH-pyrazoI-l-yllpropionamido)-methylene1-ervthromvcin A To a solution of example 7 (0.050g) in anhydrous DMF (4mL) under nitrogen atmosphere a solution of intermediate 70 (0.017g) in anhydrous DMF (ImL), HATU (0.029g) and DIPEA (0.030mL) were sequentially added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (lOmL) and washed with a saturated NaHC0 3 aqueous solution (5mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 95V5) to give a compound that was dissolved in MeOH (3mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure and purification by flash chromatography (eluting with: DCMVMeOH from 100V0 to 95.5) gave the title compound (0.007g). mVz ([MH] + ) = 832. Example 42 fllS.21Jg.S l )-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll- [oxycarbonyl-((2S)-tert-butoxycarbonylamino-3-(lH-indol-3-yl)-propionamido)- methylenel-ervthromvcin A To a solution of example 6 (0.050g) in anhydrous DMF (4mL) under nifrogen atmosphere (2S)-tert-butoxycarbonylamino-3-(lH-indol-3-yl)-ρropionic acid (0.027g), ΗATU (0.03 lg) and DIPEA (0.03 ImL) were sequentally added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, the residue dissolved in DCM (lOmL) and washed with a saturated NaΗC0 3 aqueous solution (5mL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 98V2 to 97V3) to give the title compound (0.043g). mVz ([MH] + ) = 955. Example 43 (ll-9.2lJ-.-S , )-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-f(2S.- tert-butoxycarbonylamino-3-(l---- r -indol-3-yl)-propionamido)-methylenel-ervthromvcin A A solution of example 42 (0.013g) in MeOH (2mL) was stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (O.OlOg). mVz ([MH] + ) = 913. Example 44 (llS.21S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-((2S)-2- amino-3-(lH r -indoI-3-yl)-propionamido)-methylenel-ervthromvcin A To a solution of example 42 (0.025g) in anhydrous DCM (0.5mL) cooled to 0°C trifluoroacetic acid (O.lmL) was added. After removing the ice-bath, the reaction mixture was stirred at room temperature for lh. The mixture was concentrated under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2mL). The aqueous phase was extracted with DCM (3x3mL). The collected organic extracts were dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 97V3) to give a compound that was dissolved in MeOH (ImL) and the solution was stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.004g). 'H-NMR (CDCI3) δ: 8.12 (bs, IH), 8.06 (d, IH), 7.65 (d, IH), 7.36 (d, IH), 7.19 (t, IH), 7.16 (d, IH), 7.13 (t, IH), 5.35 (dd, IH), 4,75 (dd, IH), 3.70 (dd, IH), 3.34 (dd, IH), 3.09-3.04 (m, 3H), 2.46-2.44 (m, 2H), 1.20 (d, 3H). mVz ([MH] + ) = 813. Example 45 (11 l .21i?.-y.-3-DecIadinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12αi-roxycarbonyl-(2- (quinoxalin-2-ylsulfanyl)-acetamido)-methylenel-erythromvcin A To a solution of (quinoxalin-2-ylsulfanyl)-acetic acid (0.095g) in anhydrous DMF (8.3mL) under nitrogen atmosphere HATU (0.164g) and DIPEA (0.089mL) were added. The reaction mixture was stirred at room temperature for 30min then example 6 (0.262g) was added. The reaction mixture was stirred at room temperature for 20h then it was diluted with DCM (30mL) and washed with a 5% NaHC0 3 aqueous solution (20mL). The aqueous phase was exfracted with DCM (25mL), the collected organic layers were washed with a 5% NaHC0 3 aqueous solution (20mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The residue was dissolved in MeOH (lOmL) and stirred at room temperature overnight. After evaporating the solvent the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from 100V0 to 93V7V1) to give the title compound (0.199 g). 'H-NMR (CDCI 3 ) δ: 8.67 (s, IH), 8.19 (dd, IH), 8.04 (dd, IH), 7.90 (d, IH), 7.74 (dt, IH), 7.66 (dt, IH), 5.20 (dd, IH), 4.67 (dd, IH), 4.30 (d, IH), 4.06 (m+d, 1H+1H), 3.95 (d, IH), 3.73 (q, IH), 3.52 (m, 2H), 3.16 (dd, IH), 3.06-3.0 (m, 2H), 2.52 (s, 3H), 2.50-2.40 (m, 2H), 2.42 (dd, IH), 2.27 (s, 6H), 1.92 (m, IH), 1.81-1.65 (m, 2H), 1.66 (m, IH), 1.51 (m, IH), 1.47 (s, 3H), 1.36 (d, 3H), 1.27 (d, 3H), 1.24 (m, IH), 1.24 (d, 3H), 1.23 (s, 3H), 1.12 (d, 3H), 1.06 (d, 3H), 0.81 (t, 3H). Example 46 fllS.21-yi-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(2- (quinoxalin-2-ylsuIf anyl)-acetamido)-methylenel -erythromycin A To a solution of (quinoxalin-2-ylsulfanyl)-acetic acid (0.395g) in anhydrous DMF (5mL) under nifrogen atmosphere and HATU (0.682g) and DIPEA (0.365mL) were added at room temperature. The reaction mixture was stirred at room temperature for 30min then a solution of example 7 (1.0g) in anhydrous DMF (3mL) was added. The reaction mixture was stirred at room temperature for 3h then it was poured into a 5% NaHC0 3 aqueous solution (30mL) and the solution exfracted with Et 2 0 (2x3 OmL). The collected organic layers were washed with brine (30mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The residue was dissolved in MeOH (25mL) and stirred at room temperature overnight. After evaporating the solvent the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from lOOVOVO to 93V7V0.2). Crystallisation from EtOAc gave the title compound (0.454g. (2 IS) isomer 99% pure by NMR analysis). 'H-NMR (CDC1 3 ) δ: 8.67 (s, IH), 8.19 (dd, IH), 8.04 (dd, IH), 7.90 (d, IH), 7.74 (dt, IH), 7.66 (dt, IH), 5.20 (dd, IH), 4.67 (dd, IH), 4.30 (d, IH), 4.06 (m+d, 1H+1H), 3.95 (d, IH), 3.73 (q, IH), 3.52 (m, 2H), 3.16 (dd, IH), 3.06-3.0 (m, 2H), 2.52 (s, 3H), 2.50-2.40 (m, 2H), 2.42 (dd, IH), 2.27 (s, 6H), 1.92 (m, IH), 1.81-1.65 (m, 2H), 1.66 (m, IH), 1.51 (m, IH), 1.47 (s, 3H), 1.36 (d, 3H), 1.27 (d, 3H), 1.24 (m, IH), 1.24 (d, 3H), 1.23 (s, 3H), 1.12 (d, 3H), 1.06 (d, 3H), 0.81 (t, 3H). Example 47 ril-y.21i-.-y.-3-Decladinosyl-11.12-dideoxy-6-0-methvI-3-oxo-12,ll-roxycarbonyl-(f4- (2,3-dihvdro-benzofl,41dioxin-6-yl)-4-oxo)-butyramido)-methvIenel-ervthromvcin A To a solution of 4-(2,3-dihydro-benzo[l,4]dioxin-6-yl)4-oxo-butyric acid (0.1165 g) in anhydrous DMF (9.5mL) under nitrogen atmosphere HATU (0.188g) and DIPEA (0.102mL) were added. The reaction mixture was stirred at room temperature for 30min then example 7 (0.300g) was added. The reaction mixture was stirred at room temperature for 20h then it was diluted with DCM (30mL) and washed with a 5% NaHC0 3 aqueous solution (20mL). The aqueous phase was exfracted with DCM (25mL), the collected organic layers were washed with a 5% NaHC0 3 aqueous solution (20mL), dried over Na 2 S0 4 and concenfrated under reduced pressure. The residue was dissolved in MeOH (lOmL) and stirred at room temperature overnight. After evaporating the solvent the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from lOOVOVO to 93V7V1) to give the title compound (0.170 ). 'H-NMR (CDCI3) δ: 7.52 (d, 2H), 6.89 (d, IH), 6.73 (d, NH), 5.20 (dd, IH), 4.84 (dd, IH), 4.35-4.25 (m, 5H), 4.13 (d, IH), 3.80 (q, IH), 3.60-3.55 (m, 2H), 3.32-3.22 (m, 2H), 3.18 (dd, IH), 3.10-3.00 (m, 2H), 2.65-2.55 (m, 2H), 2.60 (s, 3H), 2.44 (m, 2H), 2.27 (s, 6H), 2.27 (m, IH), 1.99 (m, IH), 1.80 (dd, IH), 1.75 (m, IH), 1.68 (m, IH), 1.60 (m, IH), 1.50 (s, 3H), 1.40 (d, 3H), 1.32 (s, 3H), 1.30 (d, 3H), 1.25 (m, IH), 1.24 (d, 3H), 1.19 (d, 3H), 1.17 (d, 3H), 0.93 (t, 3H). Example 48 (llS.21R.-y)-3-DecIadinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12-ll-foxycarbonyl-(4-(4- oxo-4.5.6 -tetrahvdro-benzor61thiophen-2-yl)-4-oxo-butyramido)-methvIenel- erythromvcin A To a solution of 4-(4-oxo-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-4-oxo-butyric acid (0.013g) in anhydrous DMF (0.850mL) under nitrogen atmosphere and HATU (0.019g) and DIPEA (O.OlOmL) were added. The reaction mixture was stirred at room temperature for 30min then example 6 (0.028g) was added. The reaction mixture was stirred at room temperature for 2.5h then it was diluted with DCM (2mL) and washed with a 5% NaHC0 3 aqueous solution (2mL). The aqueous phase was extracted with DCM (1.5mL), the collected organic layers were dried over Na 2 S0 4 and concenfrated under reduced pressure. The residue was dissolved in MeOH (5mL) and stirred at room temperature for 24h. After evaporating the solvent the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from lOOVOVO to 92V8V0.2) to give the title compound (0.031 g). 'H-NMR (CDC1 3 ) δ: 8.02 (s, IH), 6.68 (d, NH), 5.13 (dd, IH), 4.88 (dd, IH), 4.32 (d, IH), 4.14(d, IH), 3.81 (q, IH), 3.55 (m, IH), 3.28 (m, 2H), 3.21 (m, IH), 3.09-3.03 (m, 4H), 2.62 (s, 3H), 2.63-2.57 (m, 6H), 2.46 (dd, IH), 2.35 (s, 6H), 2.24 (m, 2H), 1.98 (m, IH), 1.80-1.70 (m, 3H), 1.60 (m, IH), 1.49 (s, 3H), 1.40 (d, 3H), 1.32 (s, 3H), 1.29 (d, 3H), 1.25 (m, 4H), 1.18 (d, 3H), 1.17 (d, 3H), 0.92 (t, 3H). Example 49 (llS.21S.-3-Deciadinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12αi-roxycarbonyl-(4-(4- oxo-4,5,6,7-tetrahydro-benzo \b thiophen-2-yl)- 4-oxo-butyramido)-methvIenel - erythromycin A To a solution of 4-(4-oxo-4,5,6J-tefrahydro-benzo[έ]thiophen-2-yl)-4-oxo-butyric acid (1.280g) in anhydrous DMF (12mL) under nifrogen atmosphere HATU (2.02g) and DIPEA (1.06mL) were added. The reaction mixture was stirred at room temperature for 30min then a solution of example 7 (2.90g) in anhydrous DMF (lOmL) was added. The reaction mixture was stirred at room temperature overnight then it was diluted with EtOAc (lOOmL) and washed with a 5% NaHC0 3 aqueous solution (2x5 OmL) and brine (5 OmL). The organic layer was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 98V2) to give a compound that was dissolved in MeOH (150mL) and stirred overnight. After evaporating the solvent the residue was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 97V3) to give the title compound (2.40g. (2 IS) isomer 95% pure by NMR analysis). 'H-NMR (CDCI3) δ: 8.02 (s, IH), 6.68 (d, NH), 5.13 (dd, IH), 4.88 (dd, IH), 4.32 (d, IH), 4.14(d, IH), 3.81 (q, IH), 3.55 (m, IH), 3.28 (m, 2H), 3.21 (m, IH), 3.09-3.03 (m, 4H), 2.62 (s, 3H), 2.63-2.57 (m, 6H), 2.46 (dd, IH), 2.35 (s, 6H), 2.24 (m, 2H), 1.98 ( , IH), 1.80-1.70 (m, 3H), 1.60 (m, IH), 1.49 (s, 3H), 1.40 (d, 3H), 1.32 (s, 3H), 1.29 (d, 3H), 1.25 (m, 4H), 1.18 (d, 3H), 1.17 (d, 3H), 0.92 (t, 3H). Example 50 (ll-S'.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12αi-foxycarbonyl-(4-f4- methoxy-3-nitro-phenyl)-4-oxo-butyramido)-methylenel-ervthromycin A To a solution of 4-(4-methoxy-3-nitro-phenyl)-4-oxo-butyric acid (0.136g) in anhydrous DMF (9mL) under nifrogen atmosphere HATU (0.205g) and DIPEA (0.1 lOmL) were added. The reaction mixture was stirred at room temperature for 30min then example 6 (0.300g) was added. The reaction mixture was stirred at room temperature for 2.5h then it was diluted with DCM (21mL) and washed with a 5% NaHC0 3 aqueous solution (18mL). The aqueous phase was extracted with DCM (15mL), the collected organic layers were dried over Na 2 S0 and concenfrated under reduced pressure. The residue was dissolved in MeOH (30mL) and DCM (2mL) and stirred at room temperature for 48h. After evaporating the solvent the crude material was purified by LC (mobile phase: AVB 85V15 for lmin, from 85V15 to 15V85 in 20min; λ= 255nm) to give the title compound (0.149g). 'H-NMR (CDC1 3 ) δ: 8.47 (d, IH), 8.19 (dd, IH), 7.15 (d, IH), 6.69 (d, NH), 5.18 (dd, IH), 4.85 (dd, IH), 4.31 (d, IH), 4.14 (d, IH), 4.04 (s, 3H), 3.80 (q, IH), 3.54 (m, IH), 3.32 (m, 2H), 3.18 (dd, IH), 3.06-3.0 (m, 2H), 2.66 (m, 2H), 2.60 (s, 3H), 2.46 (m, IH), 2.42 (dd, IH), 2.28 (s, 6H), 1.98 (m, IH), 1.81-1.55 (m, 4H), 1.49 (s, 3H), 1.40 (d, 3H), 1.32 (s, 3H), 1.30 (d, 3H), 1.25 (d, 3H), 1.25 (m, IH), 1.18 (d, 3H), 1.17 (d, 3H), 0.81 (t, 3H). Example 51 (ll-S l .21S)-3-Decladinosyl-llJ2-dideoxy-6-O-methyl-3-oxo-12αi-roxycarbonyl-f4-(4- methoxy-3-nitro-phenyl)-4-oxo-butyramido)-methylene1-ervthromycin A To a solution of 4-(4-methoxy-3-nitro-phenyl)-4-oxo-butyric acid (2.782g) in anhydrous DMF (36mL) under nitrogen atmosphere HATU (1.230g) and DIPEA (0.656mL) were added. The reaction mixture was stirred at room temperature for 30min then example 7 (1.8g) was added. The reaction mixture was stirred at room temperature for 3h then it was diluted with Et 2 0 (200mL) and washed with a 5% NaHC0 3 aqueous solution (2xl00mL). The aqueous phase was extracted with Et 2 0 (5 OmL) and DCM (5 OmL), the combined organic layers were dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 96V4). The obtained compound was dissolved in MeOH (lOOmL) and stirred at room temperature overnight. After evaporating the solvent the product was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 96V4) to give the title compound (1.510g, (215) isomer 95% pure by NMR analysis). 'H-NMR (CDCI3) δ: 8.47 (d, IH), 8.19 (dd, IH), 7.15 (d, IH), 6.69 (d, NH), 5.18 (dd, IH), 4.85 (dd, IH), 4.31 (d, IH), 4.14 (d, IH), 4.04 (s, -OCH 3 ), 3.80 (q, IH), 3.54 (m, IH), 3.32 (m, 2H), 3.18 (dd, IH), 3.06-3.0 (m, 2H), 2.66 (m, 2H), 2.60 (s, 3H), 2.46 (m, IH), 2.42 (dd, IH), 2.28 (s, 6H), 1.98 (m, IH), 1.81-1.55 (m, 4H), 1.49 (s, 3H), 1.40 (d, 3H), 1.32 (s, 3H), 1.30 (d, 3H), 1.25 (d, 3H), 1.25 (m, IH), 1.18 (d, 3H), 1.17 (d, 3H), 0.81 (t, 3H). Example 52 (llS.21-R,S.-3-DecIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-(4-(2- hvdroxy-4,5-dimethoxy-phenvI)-4-oxo-butyramido)-methylenel-ervthromycin A To a solution of 4-(2-hydroxy-4,5-dimethoxy-phenyl)-4-oxo-butyric acid (0.137g) in anhydrous DMF (9mL) under nifrogen atmosphere HATU (0.205g) and DIPEA (0.11 OmL) were added. The reaction mixture was stirred at room temperature for 30min then example 6 (0.300g) was added. The reaction mixture was stirred at room temperature for 2.5h then it was diluted with DCM (21mL) and washed with a 5% NaHC0 aqueous solution (18mL). The aqueous phase was extracted with DCM (15mL), the combined organic layers were dried over Na 2 S0 4 and evaporated under reduced pressure. The residue was dissolved in MeOH (lOmL) and stirred at room temperature for 24h. After evaporating the solvent the crude material was purified by LC (mobile phase: AVB from 85V15 to 15V85 in 20 min; λ= 237nm) to give the title compound (0.120g). 1H-NMR (CDC1 3 ) δ: 12.49 (s, IH), 7.14 (s, IH), 6.71 (d, NH), 6.44 (s, IH), 5.18 (dd, IH), 4.88 (dd, IH), 4.31 (d, IH), 4.14 (d, IH), 3.91 (s, 3H), 3.88 (s, 3H), 3.80 (q, IH), 3.55 (m, IH), 3.41-3.30 (m, 2H), 3.20 (dd, IH), 3.11-3.0 (m, 2H), 2.70-2.60 (m, 2H), 2.61 (s, 3H), 2.52 (m, IH), 2.43 (dd, IH), 2.31 (s, 6H), 1.98-1.70 (ro, 3H), 1.60 (m, IH), 1.50 (s, 3H), 1.30 (d, 3H), 1.26 (d, 3H), 1.25 (m, IH), 1.24 (d+d, 6H), 1.19 (d, 3H), 1.17 (d, 3H), 0.91 (t, 3H). Example 53 (H-_*.21i_.S)-3-Decladinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12αi-roxycarbonyl-f4-f3- hvdroxy-4-methoxy-phenyl)-4-oxo-butyramido)-methylenel-ervthromycin A To a solution of 4-(3-hydroxy-4-methoxy-phenyl)-4-oxo-butyric acid (0.121g) in anhydrous DMF (9mL) under nitrogen atmosphere HATU (0.205g) and DIPEA (0.11 OmL) were added. The reaction mixture was stirred at room temperature for 30min then example 6 (0.300g) was added. The reaction mixture was stirred at room temperature for 2.5h then it was diluted with DCM (2 ImL) and washed with a 5% NaHC0 3 aqueous solution (18mL). The aqueous phase was exfracted with DCM (15mL), the combined organic layers were dried over Na 2 S0 4 and concenfrated under reduced pressure. The residue was dissolved in MeOH (30mL) and DCM (2mL) and stirred at room temperature for 48h. After evaporating the solvent the crude material was purified by LC (mobile phase: AVB 85V15 for lmin, from 85V15 to 15V85 in 20 min; λ= 230nm) to give the title compound (0.020g). 'H-NMR (CDCI3) δ: 7.57 (m, 2H), 6.89 (d, IH), 6.71 (d, IH), 5.88 (bs, IH), 5.22 (dd, IH), 4.81 (dd, IH), 4.31 (d, IH), 4.13 (d, IH), 3.96 (s, 3H), 3.81 (q, IH), 3.55 (m, IH), 3.31 (m, 2H), 3.22 (m, IH), 3.09-3.04 (m, 2H), 2.66-2.54 (m, 4H), 2.61 (s, 3H), 2.44 (dd, IH), 2.34 (s, 6H), 2.00 (m, IH), 1.81-1.70 (m, 3H), 1.6 (m, IH), 1.50 (s, 3H), 1.41 (d, 3H), 1.31 (s, 3H), 1.29 (d, 3H), 1.25 (d, 3H), 1.25 (m, IH), 1.19 (d, 3H), 1.17 (d, 3H), 0.93 (t, 3H). Example 54 fllιy.21S.-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12αi-foxycarbonyl-(4-(3- hvdroxy-4-methoxy-phenyl)-4-oxo-bntyramidoVmethylenel-erythromvcin A To a solution of 4-(3-hydroxy-4-methoxy-phenyl)-4-oxo-butyric acid (0.273g) in anhydrous DMF (3.5mL), HOBT (0.165g) and EDC (0.234g) were added under nifrogen atmosphere. After stirring 5min example 7 (0.627g) was added, and the resulting mixture was stirred at room temperature for 3h. The reaction mixture was diluted with DCM (15mL) washed with a 5% NaHC0 3 aqueous solution (lOmL). The organic layer was washed with brine (10ml), dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 97V3 to 95V5) to give a compound that was dissolved in MeOH (lOmL) and stirred at room temperature overnight. After solvent evaporation the compound was purified by preparative LC (column Waters XTerra MS C18 (19 x 300mm, 7μm); flow rate = 12 mlVmin, AVB from 70V30 to 10V90 in 25min; λ= 230nm) to give the title compound (0.165g, (21S) isomer 94% pure by NMR analysis). 'H-NMR (CDC1 3 ) δ: 7.57 (m, 2H), 6.89 (d, IH), 6.71 (d, IH), 5.88 (bs, IH), 5.22 (dd, IH), 4.81 (dd, IH), 4.31 (d, IH), 4.13 (d, IH), 3.96 (s, 3H), 3.81 (q, IH), 3.55 (m, IH), 3.31 (m, 2H), 3.22 (m, IH), 3.09-3.04 (m, 2H), 2.66-2.54 (m, 4H), 2.61 (s, 3H), 2.44 (dd, IH), 2.34 (s, 6H), 2.00 (m, IH), 1.81-1.70 (m, 3H), 1.6 (m, IH), 1.50 (s, 3H), 1.41 (d, 3H), 1.31 (s, 3H), 1.29 (d, 3H), 1.25 (d, 3H), 1.25 (m, IH), 1.19 (d, 3H), 1.17 (d, 3H), 0.93 (t, 3H). Example 55 (HS.21i?.S)-3-Decladinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-(4-(3-4- dimethoxy-phenyl)-4-oxo-butyr amido)- methylenel -erythromycin A To a solution of 4-(3,4-dimethoxy-phenyl)-4-oxo-butyric acid (0.128g) in anhydrous DMF (9mL) under a nifrogen atmosphere HATU (0.205g) and DIPEA (0.1 lOmL) were added. The reaction mixture was stirred at room temperature for 30min then example 6 (0.300g) was added. The reaction mixture was stirred at room temperature for 2.5h then it was diluted with DCM (2 ImL) and washed with a 5% NaHC0 3 aqueous solution (18mL). The aqueous phase was extracted with DCM (15mL), the combined organic layers were dried over Na 2 S0 4 and concentrated under reduced pressure. The residue was dissolved in MeOH (30mL) and stirred at room temperature for 24h. After evaporating the solvent the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from lOOVOVO to 92V8V0.2) to give the title compound (0.293g). 'H-NMR (CDCI 3 ) δ: 7.95 (d, NH), 7.70 (dd, IH), 7.55 (d, IH), 6.99 (d, IH), 5.30 (dd, IH), 5.30 (dd, IH), 4.71 (m, IH), 4.37 (d, IH), 4.08 (d, IH), 3.96-3.93 (m, 4H), 3.90 (q, IH), 3.68 (m, IH), 3.39 (dd, IH), 3.34 (m, 2H), 3.19 (m, IH), 3.14 (m, IH), 2.75 (s, 6H), 2.66-2.61 (m, 6H), 2.49 (d, IH), 1.99-1.96 (m, 2H), 1.84-1.71 (m, 2H), 1.64 (m, IH), 1.56 (s, 3H), 1.41 (m+d, 1H+3H), 1.32 (d, 3H), 1.31 (s, 3H), 1.26 (d, 3H), 1.23 (d, 3H), 1.21 (d, 3H), 0.95 (t, 3H). Example 56 fll-S , .21S)-3-Decladinosyl-llJ2-dideoxy-6-O-methyl-3-oxo-12αi-roxycarbonvI-(4-f3.4- dimethoxy-phenyl -4-oxo-butyramido -methylenel -erythromycin A To a solution of 4-(3,4-dimethoxy-phenyl)-4-oxo-butyric acid (0.695g) in anhydrous DMF (15mL) under nitrogen atmosphere HATU (1.08g) and DTPEA (0.586mL) were added. The reaction mixture was stirred at room temperature for 30min then example 7 (1.50g) was added. The reaction mixture was stirred at room temperature for 18h then it was diluted with DCM (35mL) and washed with a 5% NaHC0 3 aqueous solution (30mL). The aqueous phase was exfracted with DCM (25mL), the combined organic layers were dried over Na 2 S0 and concentrated under reduced pressure. The residue was dissolved in MeOH (50mL) and stirred at room temperature for 18h. After evaporating the solvent the crude material was crystallised from DCM to give the title compound (1.26g, (2 IS) isomer 98% pure by NMR analysis). 'H-NMR (CDC1 3 ) δ: 7.95 (d, NH), 7.70 (dd, IH), 7.55 (d, IH), 6.99 (d, IH), 5.30 (dd, IH), 5.30 (dd, IH), 4.71 (m, IH), 4.37 (d, IH), 4.08 (d, IH), 3.96-3.93 (m, 4H), 3.90 (q, IH), 3.68 (m, IH), 3.39 (dd, IH), 3.34 (m, 2H), 3.19 (m, IH), 3.14 (m, IH), 2.75 (s, 6H), 2.66-2.61 (m, 6H), 2.49 (d, IH), 1.99-1.96 (m, 2H), 1.84-1.71 (m, 2H), 1.64 (m, IH), 1.56 (s, 3H), 1.41 (m+d, 1H+3H), 1.32 (d, 3H), 1.31 (s, 3H), 1.26 (d, 3H), 1.23 (d, 3H), 1.21 (d, 3H), 0.95 (t, 3H). Example 57 (llS.21R-S)-3-DecladinosyI-11.12-dideoxy-6-O-methyl-3-oxo-12αi-foxycarbonyI-(4-(4- hvdroxy-3-methoxy-phenyl)-4-oxo-butyramido)-methylenel-ervthromycin A To a solution of 4-(4-hydroxy-3-methoxy-phenyl)-4-oxo-butyric acid (0.922g) in anhydrous DMF (20mL) HOBT (0.656g) and EDC (0.933g) were added. Then example 6 (2.5g) was added, and the resulting mixture was stirred at room temperature overnight. The reaction mixture was diluted with DCM (75mL) washed with a IN HCl aqueous solution (30mL) then with a saturated NaHC0 3 aqueous solution (30mL). The organic layer was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 98V2) then dissolved in MeOH (lOmL) and stirred at room temperature overnight. Solvent evaporation gave the title compound (0.600g). 1H-NMR (CDCI 3 ) δ: 7.57 (dd, IH), 7.50 (d, IH), 6.92 (d, IH), 6.89 (d, IH), 6.05 (bs, IH), 5.19 (dd, IH), 4.80 (dd, IH), 4.28 (d, IH), 4.10 (d, IH), 3.93 (s, 3H), 3.77 (q, IH), 3.58 (bs, IH), 3.51 (m, IH), 3.30 (m, 2H), 3.17 (dd, IH), 3.06 (m, IH), 3.02 (m, IH), 2.6 (m, 3H), 2.57 (s, 3H), 2.48 (bm, IH), 2.41 (dd, IH), 2.28 (bs, 6H), 1.95 (m, IH), 1.81-1.50 (m, 4H), 1.47 (s, 3H), 1.37 (d, 3H), 1.28 (s, 3H), 1.27 (d, 4H), 1.22 (d, 3H), 1.17 (d, 3H), 1.15 (d, 3H), 0.90 (t, 3H). Example 58 (ll--».21S.-3-Decladinosyl-llJ2-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonvI-(4-(4- hvdroxy-3-methoxy-phenyl -4-oxo-butyramido)-methylenel-ervthromycin A To a solution of 4-(4-hydroxy-3-methoxy-phenyl)-4-oxo-butyric acid (0.720g) in anhydrous DMF (12mL) HOBT (0.259g) and EDC (0.368g) were added under nifrogen atmosphere. Then example 7 (1.65g) was added, and the resulting mixture was stirred at room temperature overnight. The reaction mixture was diluted with DCM (50mL) washed with a IN HCl aqueous solution (20mL) then with a saturated NaHC0 3 aqueous solution (20mL). The organic layer was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 98V2) then dissolved in MeOH (lOmL) and stirred at room temperature overnight. Solvent evaporation gave the title compound (0.360g, (21S) isomer 95% pure by NMR analysis). 1H-NMR (CDC1 3 ) δ: 7.57 (dd, IH), 7.50 (d, IH), 6.92 (d, IH), 6.89 (d, IH), 6.05 (bs, IH), 5.19 (dd, IH), 4.80 (dd, IH), 4.28 (d, IH), 4.10 (d, IH), 3.93 (s, 3H), 3.77 (q, IH), 3.58 (bs, IH), 3.51 (m, IH), 3.30 (m, 2H), 3.17 (dd, IH), 3.06 (m, IH), 3.02 (m, IH), 2.6 (m, 3H), 2.57 (s, 3H), 2.48 (bm, IH), 2.41 (dd, IH), 2.28 (bs, 6H), 1.95 (m, IH), 1.81-1.50 (m, 4H), 1.47 (s, 3H), 1.37 (d, 3H), 1.28 (s, 3H), 1.27 (d, 4H), 1.22 (d, 3H), 1.17 (d, 3H), 1.15 (d, 3H), 0.90 (t, 3H). Example 59 fllS l .21_g.-_t)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonvI-(2-(3- methoxy-quinoxalin-2-ylsulfanyl)-acetamido -methylene1-ervthromycin A To a solution of intermediate 72 (0.032g) in anhydrous DMF (2mL) HATU (0.048g) and DIPEA (0.022mL) were added under nitrogen atmosphere. After stirring for 45min example 7 (0.070g) was added and the mixture stirred overnight. Water (5mL) was added and the solution exfracted with DCM (2x1 OmL). The organic phase was washed with brine (5mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The residue was dissolved in MeOH (5mL) and stirred overnight. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 94V6) to give the title compound (0.060g). mVz ([MH] + ) = 859 1H-NMR (CDCI 3 ) δ: 8.09 (d, IH), 7.78 (d, IH), 7.81 (d, IH), 7.56 (t, IH), 7.53 (t, IH), 4.65 (t, IH), 4.15 (s, 3H), 4.06 (d, IH), 3.90 (d, IH), 3.03 (m, IH), 2.42 (m, IH), 1.10 (d, 3H). Example 60 (llS.21-R.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2- (quinoxalin-2-yloxy)-acetamido)-methylenel -erythromycin A To a solution of intermediate 74 (0.038g) in anhydrous DMF (1.5mL) HATU (0.072g) and DIPEA (0.033mL) were added under nifrogen atmosphere. After stirring for 45min example 7 (0.090g) was added and the mixture stirred overnight. Water (8mL) was added and the solution exfracted with DCM (2x15mL). Collected organic phases were washed with a saturated NaHC0 3 aqueous solution (lOmL), brine (lOmL), then dried over Na 2 S0 4 and concenfrated under reduced pressure. The residue was dissolved in MeOH (5mL) and stirred overnight. Purification of the crude material by flash chromatography (eluting with: DCMVMeOH 95V5) gave the title compound (0.047g). mVz ([MH] + ) = 813 'H-NMR (CDCI 3 ) δ: 8.35 (s, IH), 7.86 (d, IH), 7.57 (td, IH), 7.36 (m, 2H), 7.26 (d, IH), 5.10 (dd, IH), 5.02 (d, IH), 4.87 (d, IH), 3.01 (m, IH), 2.34 (m, IH), 1.11 (d, 3H). Example 61 αiS.21-R--y)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-(4-f3- amino-4-methoxy-phenyl -4-oxo-butyramido)-methylenel-ervthromycin A To a solution of example 51 (0.070g) in anhydrous MeOH (5mL) palladium (lOwt. % on carbon powder, 0.050g) was added and the mixture stirred under hydrogen atmosphere (1 atm) for lhr. Filtration through a silica pad eluting with MeOH and purification by preparative TLC (eluting with: DCMVMeOH 90V10) gave the title compound (0.008g). 1H-NMR (CDC1 3 ) δ: 8.47 (d, IH), 8.19 (d, IH), 7.15 (d, IH), 6.68 (d, IH), 4.82 (d, IH), 4.04 (s, 3H), 3.32 (t, 2H), 3.07 (m, IH), 2.70-2.60 (m, 2H), 2.39 (m, IH), 2.08 (s, 3H), 1.11 (d, 3H) Example 62 (115'.21_R.S)-3-Decladinosyl-11.12-dideoxy-6-O-methvI-3-oxo-12αi-roxycarbonyl-(4- hvdroxymino-4-(4-methoxy-3-nitro-phenyl)-butyramido)-methylenel-ervthromycin A To a solution of example 51 (0.050g) in anhydrous MeOH (ImL) hydroxylamine hydrochloride (0.050g) and ammonium acetate (O.lOOg) were added. The reaction mixture was stirred at 60°C for 3h. After solvent evaporation, the crude material was purified by flash chromatography (eluting with: DCMVMeOH 90V10) to give the title compound (0.015g). 1H-NMR (CDCI3) δ: 8.17 (d, IH), 7.82 (dd, IH), 7.13 (d, IH), 6.58 (bm, IH), 4.80 (m, IH), 3.00 (m, IH), 3.10 (m, 2H), 2.50 (m, 2H), 2.34 (m, IH), 1.14 (d, 3H). Example 63 (ll-_*.21i_._y)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl-(2- (quinoxaUne-2-sulfonyl)-acetamidoVmethvIenel-ervthromvcin A To a solution of example 46 (0.050g) in a 1V1 mixture of waterVDCM (4mL) magnesium monoperoxyphtalate (0.040g) was added. After stirring for 24h the aqueous phase was exfracted with DCM (3x5mL), the organic extracts washed with a 5% Na 2 S 2 0 5 aqueous solution (5mL), dried over Na 2 S0 4 and concentrated under reduced pressure. The residue was dissolved in THF (ImL), polystyrene friphenylphosphine resin (0.050g) was added and the mixture heated to 65°C for 2h. After cooling to room temperature, the mixture was filtered and concentrated to give the title compound (0.050g). 'H-NMR (CDCI 3 ) δ: 9.52 (s, IH), 8.24 (m, IH), 8.00-7.80 (m, 2H), 7.70 (bm, IH), 4.83 (m, IH), 4.49 (d, IH), 4.04 (d, IH), 3.06 (m, IH), 2.50 (m, IH), 1.15 (d, 3H). Example 64 (llS,21 J R._y)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12Jl-loxycarbonyl-f3- phenyl-propylaminoVmethylenel -erythromycin A A solution of example 6 (0.045g) and 3-phenyl propionaldehyde (O.OlOmL) in anhydrous MeOH (ImL) was stirred at room temperature for lh under nifrogen atmosphere. Then sodium cyanoborohydride (0.007g) and acetic acid (0.004mL) were added. The mixture was stirred at room temperature for lh then the reaction was quenched with a saturated NaHC0 3 aqueous solution (2mL). After solvent evaporation, the aqueous phase was extracted with DCM (3xl0mL), the organic layer dried over Na 2 S0 4 and concentrated under reduced pressure. The residue was dissolved in MeOH (ImL) and stirred at room temperature overnight. After evaporating the solvent the crude material was purified by flash chromatography (eluting with: DCM VMeOH 95V5) to give the title compound (0.039g). H-NMR (CDCI3) δ: 7.40-7.00 (m, 5H), 5.74 (dd, IH), 4.31 (d, IH), 4.25 (d, IH), 4.13 (s, IH), 3.84 (q, IH), 3.54 (m, IH), 3.18 (m, IH), 3.11 (m, IH), 3.03 (m, IH), 2.92-2.83 (m, 2H), 2.68 (s, 3H), 2.64 (m, 2H), 2.58 (m, IH), 2.46 (m, IH), 2.33 (ro, IH), 2.27 (s, 6H), 1.92 (m, IH), 1.76 (m, 4H), 1.67 (m, IH), 1.57 (m, IH), 1.48 (s, 3H), 1.38 (d, 3H), 1.31 (d, 3H), 1.33 (s, 3H), 1.25 (d, 3H), 1.15 (d, 3H), 1.09 (d, 3H), 0.87 (t, 3H). TLC: DCMVMeOH 10V1 (Rf=0.25). Example 65 (H-S'.21R,-S l )-3-Decladinosyl-liα2-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonvI-f3-f4- (pyridin-3-yl)-imidazol-l-yl)-propylamino)-methylenel-ervthromycin A A solution of example 6 (O.lOOg) and intermediate 52 (0.040g) in anhydrous DCM (4mL) was stirred at room temperature for 6h under nifrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.150mL) and acetic acid (0.009mL) were added and the mixture stirred for 48h. The reaction was quenched with a saturated NaHC0 3 aqueous solution (lOmL) and extracted with DCM (3xl5mL). The organic layer was dried over Na 2 S0 and concentrated under reduced pressure. The residue was dissolved in MeOH (5mL) and heated to reflux temperature for 48h. After evaporating the solvent the crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 90V10) to give the title compound (0.008g). 'H-NMR (CDCI3) δ: 9.00 (d, IH), 8.45 (d, IH), 8.11 (d, IH), 7.59 (d, IH), 7.39 (d, IH), 7.29 (m, IH), 5.55 (dd, IH), 4.29 (d, IH), 4.24 (d, IH), 4.13 (s, IH), 4.20-4.0 (m, 2H), 3.86 (q, IH), 3.55 (m, IH), 3.19 (m, IH), 3.09 (m, IH), 3.05 (m, IH), 2.93 (m, 2H), 2.67 (s, 3H), 2.52 (m, IH), 2.49 (m, IH), 2.32 (d, IH), 2.27 (s, 6H), 2.02 (m, IH), 1.94 (m, 2H), 1.80 (m, 2H), 1.65 (m, IH), 1.60 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.33 (s, 3H), 1.31 (d, 3H), 1.25 (m, IH), 1.24 (d, 3H), 1.16 (d, 3H), 1.09 (d, 3H), 0.87 (t, 3H). Example 66 (llS.21S)-3-Decladinosyl-liα2-dideoxy-6-Q-methyl-3-oxo-12ai-foxycarbonyl-(3-(4- (pyridin-3-yl)-imidazol-l-vI -propylamino -methylenel-ervthromycin A A solution of example 7 (0.500g) and intermediate 52 (0.180g) in anhydrous acetonitrile (7mL) was stirred at room temperature for 2h under nifrogen atmosphere. The solvent was evaporated and the residue dissolved in anhydrous MeOH (5mL). Then sodium cyanoborohydride (IM in THF, 0.375ml) and acetic acid (0.045ml) were added under nifrogen atmosphere and the mixture stirred overnight. The reaction was quenched with a saturated NaHCO 3 aqueous solution (lOmL) and exfracted with DCM (3xl5mL). The organic layer was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCM VMeOH 90V10) to give the title compound (0.170g, (21S) isomer 95% pure by NMR analysis). 'H-NMR (CDCI 3 ) δ: 9.00 (d, IH), 8.45 (d, IH), 8.11 (d, IH), 7.59 (d, IH), 7.39 (d, IH), 7.29 (m, IH), 5.55 (dd, IH), 4.29 (d, IH), 4.24 (d, IH), 4.13 (s, IH), 4.20-4.0 (m, 2H), 3.86 (q, IH), 3.55 (m, IH), 3.19 (m, IH), 3.09 (m, IH), 3.05 (m, IH), 2.93 (m, 2H), 2.67 (s, 3H), 2.52 (m, IH), 2.49 (m, IH), 2.32 (d, IH), 2.27 (s, 6H), 2.02 (m, IH), 1.94 (m, 2H), 1.80 (m, 2H), 1.65 (m, IH), 1.60 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.33 (s, 3H), 1.31 (d, 3H), 1.25 (m, IH), 1.24 (d, 3H), 1.16 (d, 3H), 1.09 (d, 3H), 0.87 (t, 3H). Example 67 (HS.21i?,-S r )-3-DecIadinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12αi-roxycarbonyl-(4-(4- (pyridin-3-yl)-imidazol-l-yl)-butylamino)-methylene]-erythromvcin A A solution of example 6 (O.lOOg) and intermediate 54 (0.050g) in anhydrous DCM (3mL) was stirred at room temperature for 24h under nifrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.120mL) and acetic acid (0.008mL) were added under nifrogen atmosphere and the mixture stirred for lh. The reaction was quenched with a saturated NaHC0 3 aqueous solution (5mL) and exfracted with DCM (3xl0mL). The organic layer was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 95V5 to 90 10) to give a compound that was dissolved in MeOH (2mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.015g). !H-NMR (CDC1 3 ) δ: 8.98 (d, IH), 8.46 (d, IH), 8.09 (d, IH), 7.56 (d, IH), 7.36 (d, IH), 7.30 (m, IH), 5.67 (dd, IH), 4.30 (d, IH), 4.24 (d, IH), 4.13 (s, IH), 4.00 (m, 2H), 3.85 (q, IH), 3.56 (m, IH), 3.19 (m, IH), 3.09 (m, IH), 3.03 (m, IH), 2.91 (m, 2H), 2.64 (s, 3H), 2.58 (m, IH), 2.47 (m, IH), 2.28 (m+s, 6H +1H), 2.00 (m, IH), 1.89 (m, 2H), 1.79 (m, IH), 1.70 (m, 2H), 1.60-1.50 (m, 2H), 1.48 (s, 3H), 1.39 (d, 3H), 1.31 (s, 3H), 1.31 (d, 3H), 1.25 (d, 3H), 1.25 (m, IH), 1.15 (d, 3H), 1.09 (d, 3H), 0.83 (t, 3H). Example 68 (llS,21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(5-(4- (pyridin-3-yl)-imidazol-l-yl)-pentyIamino)-methvIenel-ervthromvcin A A solution of example 6 (0.080g) and intermediate 56 (0.042g) in anhydrous DCM (5mL) was stirred at room temperature for lh under nifrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.120mL) and HCl (2N in Et 2 0, O.OlOmL) were added under nifrogen atmosphere and the mixture stirred for lh. The reaction was quenched with a saturated NaHC0 3 aqueous solution (lOmL) and exfracted with DCM (3x15mL). The organic layer was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with DCMVMeOH from 96V4 to 90V10) to give a compound that was dissolved in MeOH (3mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.013g). 'H-NMR (CDCI 3 ) δ: 8.99 (d, IH), 8.47 (d, IH), 8.10 (d, IH), 7.55 (s, IH), 7.31 (s, IH), 7.29 (m, IH), 5.67 (dd, IH), 4.30 (d, IH), 4.25 (d, IH), 4.11 (s, IH), 3.96 (m, 2H), 3.85 (q, IH), 3.58 (m, IH), 3.18 (dd, IH), 3.09 (m, IH), 3.02 (m, IH), 2.90-2.75 (m, 2H), 2.67 (s, 3H), 2.58 (m, IH), 2.46 (m, IH), 2.29 (d, IH), 2.27 (s, 6H), 1.90-1.86 (m, 3H), 1.78 (m, IH), 1.70 (m, 2H), 1.60-1.50 (m, 3H), 1.47 (s, 3H), 1.5-1.4 (m, 4H), 1.38 (d, 3H), 1.33 (s, 3H), 1.32 (d, 3H), 1.28 (d, 3H), 1.25 (m, IH), 1.15 (d, 3H), 1.09 (d, 3H), 0.85 (t, 3H). Example 69 αi_S'.21_g^_f.-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12Jl-roxycarbonyl-(2-f4- (pyridin-3-yl)-imidazol-l-yl)-ethylamino)-methylenel-ervthromvcin A A solution of intermediate 51 (0.040g) in acetonitrile (ImL) and a 2M HCl aqueous solution (3mL) was heated to 80°C for 3h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 6 (O.lOOg) dissolved in anhydrous acetonitrile (4mL) keeping the pH of the solution in the range 6-7 by addition of a saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature for 2h. Acetic acid was added to the mixture to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.150mL). The reaction mixture was stirred overnight at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (5mL) was added and the product was exfracted with DCM (3xl0mL). The organic layer was dried over Na 2 S0 and concentrated under vacuum. The crude material was purified by flash chromatography (eluting with DCMVMeOH 94V6) affording the title compound (0.027g). 'H-NMR (CDC1 3 ) δ: 9.04 (d, IH), 8.46 (dd, IH), 8.12 (d, IH), 7.61 (d, IH), 7.56 (m, IH), 7.30 (m, IH), 5.63 (dd, IH), 4.27 (d, IH), 4.22 (d, IH), 4.19 (d, IH), 4.20-4.08 (m, 2H), 3.84 (q, IH), 3.54 (m, IH), 3.36-3.19 (m, 2H), 3.16 (dd, IH), 3.05 (m, 2H), 2.55 (m, IH), 2.44 (m, IH), 2.43 (s, 3H), 2.28 (s, IH), 2.27 (s, 6H), 1.85 (m, IH), 1.75 (m, IH), 1.70-1.65 (m, 2H), 1.55 (m, IH), 1.48 (s, 3H), 1.40 (d, 3H), 1.30 (d, 3H), 1.24-1.20 (m, 4H), 1.23 (s, 3H), 1.14 (d, 3H), 1.09 (d, 3H), 0.82 (t, 3H). Example 70 (llS,21S r )-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonvI-(2-(4- (pyridin-3-yl)-imidazoI-l-yl -ethylamino -methyIenel-erythromvcin A A solution of intermediate 51 (0.530g) in acetonifrile (30mL) and a 3M HCl aqueous solution (20mL) was heated to 80°C for 3h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 7 (0.500g) dissolved in anhydrous acetonitrile (2mL) keeping the pH of the solution in the range 6-7 by addition of saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature for lh. Acetic acid was added to the mixture to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.75mL). The reaction mixture was stirred overnight at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (15mL) was added and the mixture was exfracted with DCM (3x20mL). The organic layer was dried over Na 2 S0 4 and concentrated under reduced pressure. The residue was dissolved in MeOH (lOmL) and stirred overnight. After evaporating the solvent the crude material was purified by flash chromatography (eluting with DCMVMeOH from 98V2 to 90V10) to give the title compound (0.350g, (21S) isomer 95% pure by NMR analysis). 'H-NMR (CDC1 3 ) δ: 9.04 (d, IH), 8.46 (dd, IH), 8.12 (d, IH), 7.61 (d, IH), 7.56 (m, IH), 7.30 (m, IH), 5.63 (dd, IH), 4.27 (d, IH), 4.22 (d, IH), 4.19 (d, IH), 4.20-4.08 (m, 2H), 3.84 (q, IH), 3.54 (m, IH), 3.36-3.19 (m, 2H), 3.16 (dd, IH), 3.05 (m, 2H), 2.55 (m, IH), 2.44 (m, IH), 2.43 (s, 3H), 2.28 (s, IH), 2.27 (s, 6H), 1.85 (m, IH), 1.75 (m, IH), 1.70-1.65 (m, 2H), 1.55 (m, IH), 1.48 (s, 3H), 1.40 (d, 3H), 1.30 (d, 3H), 1.24-1.20 (m, 4H), 1.23 (s, 3H), 1.14 (d, 3H), 1.09 (d, 3H), 0.82 (t, 3H). Example 71 (ll-S'-21R.S.-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12αi-loxycarbonyl-(5- (quinolin-4-yl)-pentylamino)-methylenel-ervthromycin A A solution of example 6 (0.084g) and intermediate 63 (0.040g) in anhydrous DCM (4mL) was stirred at room temperature for lh under nitrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.125mL) and acetic acid (0.007mL) were added and the mixture stirred overnight. The reaction was quenched with a saturated NaHC0 3 aqueous solution (lOmL) and exfracted with DCM (3x1 OmL). The organic layer was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with DCMVMeOH 90V10) to give a compound that was dissolved in MeOH (3mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.006g). iH-NMR (CDC1 3 ) δ: 8.81 (d, IH), 8.11 (d, IH), 8.06 (d, IH), 7.70 (t, IH), 7.57 (t, IH), 7.26 (d, IH), 5.71 (dd, IH), 4.31 (d, IH), 4.26 (d, IH), 4.12 (d, IH), 3.85 (q, IH), 3.55 (m, IH), 3.19 (m, IH), 3.10 (m, IH), 3.07 ( , 2H), 3.03 (m, IH), 2.90 (m, IH), 2.80 (m, IH), 2.68 (s, 3H), 2.58 (m, IH), 2.45 ( , IH), 2.30 (d, IH), 2.27 (s, 6H), 1.90 (m, IH), 1.75 (m, 2H), 1.70 (m, 3H), 1.52 (m, 2H), 1.48 (s, 3H), 1.37 (d, 3H), 1.33 (s, 3H), 1.32 (d, 3H), 1.24 (m, IH), 1.25 (d, 3H), 1.15 (d, 3H), 1.09 (d, 3H), 0.85 (t, 3H). Example 72 (ll--t.21-R.-_>)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonvI-(3- (quinolin-4-yl)-propyIamino -methylenel -erythromycin A A solution of example 6 (O.lOOg) and 3-quinolin-4-yl-propionaldehyde (0.03 lg) in anhydrous DCM (4mL) was stirred at room temperature for 2h under nifrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.150mL) and acetic acid (0.009mL) were added and the mixture stirred overnight. The reaction was quenched with a saturated NaHC0 3 aqueous solution (lOmL) and exfracted with DCM (3x1 OmL). The organic layer was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with DCMVMeOH 95V5) to give a compound that was dissolved in MeOH (3mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.01 lg). !H-NMR (CDCI 3 ) δ: 8.80 (d, IH), 8.13-8.09 (d, 2H), 7.70 (t, IH), 7.58 (t, IH), 7.30 (m, IH), 5.80 (dd, IH), 4.31 (d, IH), 4.26 (d, IH), 4.19 (s, IH), 3.86 (q, IH), 3.56 (m, IH), 3.50 (bm, IH), 3.26 (m, IH), 3.19 (m, IH), 3.12 (m, IH), 3.06 (m, 3H), 2.90 (m, IH), 2.69 (s, 3H), 2.58 (m, IH), 2.46 (m, IH), 2.36 (d, IH), 2.27 (s, 6H), 1.92 (m, 3H), 1.80-1.70 (m, 2H), 1.65 (m, IH), 1.60 (m, IH), 1.50 (s, 3H), 1.40 (d, 3H), 1.33 (s+d, 3H+3H), 1.24 (m, 4H), 1.16 (d, 3H), 1.11 (d, 3H), 0.87 (t, 3H). Example 73 (1 lS.21i-.S)-3-Decladinosyl-l iα2-dideoxy-6-O-methyl-3-oxo-12,l 1- roxycarbonyl-(4- (quinolin-4-yl)-butylamino -methylenel -erythromycin A A solution of example 6 (0.130g) and intermediate 59 (0.047g) in anhydrous THF (5mL) was stirred at room temperature for lhr under nifrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.195mL) and acetic acid until pH=5 were added and the mixture stirred for 3h. The reaction was quenched with a saturated NaHC0 3 aqueous solution (lOmL) and exfracted with DCM (3xl0mL). The organic layer was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with DCMVMeOH from 98V2 to 96V4) to give a compound that was dissolved in MeOH (5mL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.015 g). Example 74 fll_y.21i-'.-S r .-3-DecIadinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-(2- (quinolin-4-yl)-ethyIamino)-methylenel-erythromvcin A A solution of intermediate 57 (0.270g) in acetonifrile (4mL) and 3M HCl aqueous solution (4mL) was heated to 50°C for 24h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 6 (0.500g) in anhydrous acetonitrile (4mL) keeping the pH of the solution in the range 6-7 by addition of a saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature for 3h. Acetic acid was added to the mixture to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.75mL). The reaction mixture was stirred overnight at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (15mL) was added and the mixture was extracted with DCM (3x20mL). The organic layer was dried over Na 2 S0 4 and concenfrated under vacuum. The residue was dissolved in MeOH (lOmL) and stirred overnight. After solvent evaporation the crude material was purified by flash chromatography (eluting with DCMVMeOH from 98V2 to 90V10) to give the title compound (0.190g). iH-NMR (CDC1 3 ) δ: 8.79 (d, IH), 8.09 (m, IH), 7.69 (t, IH), 7.56 (t, IH), 7.38 (d, IH), 5.68 (dd, IH), 4.29 (d, IH), 4.22 (d, IH), 4.21 (s, IH), 3.83 (q, IH), 3.54 (m, IH), 3.41-3.1 (m, 4H), 3.17 (dd, IH), 3.07 (m, IH), 3.02 (m, IH), 2.45 (m, 2H + -OCH 3 ), 2.30 (m, IH), 2.27 (s, N(CH 3 ) 2 ), 1.88 (m, IH), 1.75 (m, 2H), 1.66 (m, IH), 1.55 (m, IH), 1.47 (s, 3H), 1.37 (d, 3H), 1.30 (d, 3H), 1.25 (d, 3H), 1.25 (m, 4H), 1.12 (d, 3H), 1.08 (d, 3H), 0.85 (t, 3H). Example 75 (HS'.21S)-3-Decladinosyl-ll,12-dideoxy-6-0-methvI-3-oxo-12,ll-roxycarbonyl-(2- (quinolin-4-yl)-ethylamino)-methyIenel -erythromycin A A solution of intermediate 57 (0.832g) in acetonifrile (16mL) and a 3M HCl aqueous solution (16mL) was heated to 50°C for 16h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 7 (1.500g) in anhydrous acetonitrile (12mL) keeping the pH of the solution in the range 6-7 by addition of a saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature for lh. Acetic acid was added to the mixture to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 3.3mL). The reaction mixture was stirred overnight at room temperature. After evaporating the solvent water (lOOmL) was added and the mixture exfracted with EtOAc (2xl00mL). The organic layer was dried over Na 2 S0 4 and concentrated under vacuum. The crude material was purified by flash chromatography (DCMVMeOH 95.5). The obtained compound was dissolved in MeOH (20mL) and stirred overnight. After solvent evaporation the compound was purified by flash chromatography (eluting with DCMVMeOH 95V5) to give the title compound (0.365g, (21S) isomer 95% pure by NMR analysis). 'H-NMR (CDCI 3 ) δ: 8.79 (d, IH), 8.09 (m, IH), 7.69 (t, IH), 7.56 (t, IH), 7.38 (d, IH), 5.68 (dd, IH), 4.29 (d, IH), 4.22 (d, IH), 4.21 (s, IH), 3.83 (q, IH), 3.54 (m, IH), 3.41-3.1 (m, 4H), 3.17 (dd, IH), 3.07 (m, IH), 3.02 (m, IH), 2.45 (m, 2H + 3H), 2.30 (m, IH), 2.27 (s, 6H), 1.88 (m, IH), 1.75 (m, 2H), 1.66 (m, IH), 1.55 (m, IH), 1.47 (s, 3H), 1.37 (d, 3H), 1.30 (d, 3H), 1.25 (d, 3H), 1.25 (m, 4H), 1.12 (d, 3H), 1.08 (d, 3H), 0.85 (t, 3H). Example 76 (ll-_>.21S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyI- ((quinoϋn-4-ylVmethylaminoV methylenel -erythromycin A A solution of example 7 (0.050g) and quinoline-4-carbaldehyde (0.020g) in anhydrous toluene (3mL) was stirred at 100°C for 16h under nitrogen atmosphere. After evaporation of the solvent the crude material was dissolved in anhydrous MeOH (5mL) palladium (lOwt. % on carbon powder, 0.006g) was added and the mixture stirred under hydrogen atmosphere (1 atm) for 5h. Filfration through a celite pad eluting with MeOH and purification by flash chromatography (eluting with: DCMVMeOH 93V7) gave the title compound (0.007g). mVz ([MH] + ) = 768 •■ -H-NMR (CDCI 3 ) δ: 8.89 (d, IH), 8.11 (d, IH), 8.09 (d, IH), 7.69 (t, IH), 7.60 (t, IH), 7.56 (t, IH), 4.65 (m, IH), 4.48 (m, IH), 4.38 (m, IH), 3.09 (m, IH), 2.43 (m, IH), 1.14 (d, 3H). Example 77 fllS.21i-.S)-3-Decladinosyl-11.12-dideoxy-6-O-methvI-3-oxo-12Jl-roxycarbonyl-f3-(5- methyl-furan-2-yl)-btttylaminoVmethylenel-ervthromycin A A solution of 3-(5-methyl-2-furyl)butanal (0.030g) and example 6 (0.067g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 5h under nitrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.250mL) and acetic acid (0.025mL) were added and the mixture was stirred at room temperature for 24h. MeOH (ImL) was added and the reaction mixture heated to 60°C for 24h. After evaporation under reduced pressure the residue was dissolved in DCM (lOmL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH 95V5V0.5) to give the title compound (0.029g). ■■■ H-NMR (CDCI3) δ: 5.82 (m, 2H), 4.10 (m, IH), 3.02 (m, IH), 2.86 (s, 2H), 2.77 (m, IH), 2.40-2.20 (m, 3H+1H), 1.80-1.60 (m, 2H), 1.08 (d, 3H). Example 78 (ll-S',21-R.»S r )-3-DecIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(3- Pyridin-4-yl-prop-2-enylamino)-methylenel-erythromvcin A A solution of 3-(5-methyl-2-furyl)butanal oxalate (0.045g), example 6 (0.067g) and DIPEA (0.05 ImL) in anhydrous acetonitrile (ImL) was stirred at room temperature for 1.5h under nifrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.25 OmL) and acetic acid (0.025mL) were added and the mixture was stirred at room temperature for 15h. MeOH (ImL) was added and the reaction mixture heated to 60°C for 48h. After evaporation under reduced pressure the residue was dissolved in DCM (lOmL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCM, DCMVMeOHVNH 4 OH from 96V4V0.1 to 92V8V0.2) to give the title compound (0.016g). mVz ([MH] + ) = 744. 1H-NMR (CDC1 3 ) δ: 8.52 (d, 2H), 7.28 (d, 2H), 6.59 (dd, 2H), 4.24 (m, IH), 3.65 (m, 2H), 3.05 (m, IH), 2.38 (m, IH), 1.10 (d, 3H). Example 79 (ll-S'.21-R,S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(3-f4- (3,5-difluoro-phenyl)-pyrazol-l-yl)-propylamino)-methylenel-ervthromycin A To a solution of example 7 (0.030g) in anhydrous THF (ImL) intermediate 75 (0.050g) was added and the mixture was stirred at room temperature for 3h under nitrogen atmosphere. Then sodium cyanoborohydride (IM in THF, 0.150mL) and acetic acid (O.OlOmL) were added and the mixture was allowed to react for 4h.The solvent was evaporated under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The residue was dissolved in MeOH (ImL) and the mixture stirred overnight. After evaporation of the solvent the crude material was purified by flash chromatography (eluting with: DCMVMeOH 90V10) to give the title compound ((0.014g). 1H-NMR (CDCI 3 ) δ: 7.83 (s, IH), 7.73 (s, IH), 7.03 (dd, IH), 6.62 (tt, IH), 4.28 (m, 2H), 4.12 (s, IH), 3.04 (m, IH), 2.91 (m, IH), 2.82 (m, IH), 2.32 (bs, 2H), 2.07 (m, IH), 2.00 (m, IH), 1.09 (d, 3H). Example 80 (ll-S , .21-g.S.-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonvI-f3-f4- (4-chloro-phenyl)-2,5-dimethyl-imidazol-l-yl)-propyIamino)-methylenel-ervthromycin A A solution of example 7 (0.050g) and intermediate 76 (0.025g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 5h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the residue dissolved in anhydrous MeOH (1.5mL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.005mL) were added. After 18h the solvent was evaporated under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.028g). *H-NMR (CDCI 3 ) δ: 7.55 (d, 2H), 7.33 (d, 2H), 4.15 (m, IH), 4.00 (m, IH), 3.85 (m, IH), 3.05 (m, IH), 3.02-2.90 (m, 2H), 2.42 (s, 3H), 2.35 (s, 3H), 2.33 (m, IH), 1.90 (m, IH), 1.72 (m, IH), 1.09 (d, 3H). Example 81 (llS.21-?.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(3-(4- (4-nitro-phenyl)-imidazol-l-yl)-propylamino)-methylenel-ervthromvcin A A solution of example 7 (0.050g) and intermediate 77 (0.023g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 18h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.005mL) were added. After 24h the solvent was evaporated under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.007g). -1H-NMR (CDCI 3 ) δ: 8.24 (d, 2H), 7.96 (d, 2H), 7.61 (d, IH), 7.54 (d, IH), 4.14 (m, IH), 4.20÷4.06 (m, 2H), 3.00÷2.88 (m, 2H), 2.32 (m, IH), 2.03 (m, IH), 1.92 (m, IH). Example 82 (ll-_>.21-R.--D-3-DecladinosvI-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(3-(4- pyridin-4-yl-imidazoI-l-yl)-propylamino)-methylenel-ervthromycin A A solution of example 7 (0.050g) and intermediate 78 (0.025g) in anhydrous acetonitrile (2mL) was stirred at room temperature for 16h under nitrogen atmosphere then heated to 50°C for 4h. After evaporating the solvent under reduced pressure, the crude was dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, O.lOOmL) and acetic acid (0.006mL) were added. After 24h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 90 10) to give the title compound (0.014g). iH-NM (CDCI 3 ) δ: 8.57 (d, IH), 7.70 (d, IH), 7.62 (s, IH), 7.52 (s, IH), 4.20-4.16 (m, 2H), 3.05 (m, IH), 2.96-2.88 (m, 2H), 2.32 (m, IH), 2.02 - 1.92 (m+m, 2H), 1.10 (d, 3H). Example 83 (11 .21i?.S.-3-DecIadinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12 i-roxycarbonyl-f3-f3- trifluoromethyl- lH-pyrazoI-4-yl)-propylamino)-methylenel-ervthromvcin A A solution of example 7 (0.020g) and intermediate 79 (0.015g) in anhydrous acetonitrile (2mL) was stirred at room temperature for 3h under nitrogen atmosphere then heated to 40°C for 4h. After evaporating the solvent under reduced pressure, the crude material was dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.015mL) and acetic acid (0.003mL) were added. After 24h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 98V2) to give the title compound (0.004g). iH-NMR (CDCI 3 ) δ: 7.53 (s, IH), 4.12 (d, IH), 3.03 (m, IH), 2.92 (m, IH), 2.84 (m, IH), 2.70-2.60 (m, 2H), 2.11 (m, IH), 1.70 (m, 2H), 1.09 (d, 3H). Example 84 (H-S'.21--?.-y)-3-DecIadinosyl-liα2-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonvI-(3-(5- methyl-4-(4-trifluoromethyl-phenyl)-imidazol-l-yl)-propylamino -methylenel- ervthromycin A A solution of example 7 (0.050g) and intermediate 80 (0.038g) in anhydrous acetonitrile (ImL) was stirred at room temperature overnight under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (ImL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 24h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from 98V2V0 to 95V5V0.5) and by preparative TLC (DCMVMeOHVNH 4 OH 90V9V0.5) to give the title compound (0.017g). 'H-NMR (CDCI 3 ) δ: 7,78 (d, 2H), 7.64 (d, 2H), 7.59 (s, IH), 5.60 (dd, IH), 4.30 (d, IH), 4.25 (d, IH), 4.15 (s, IH), 4.10 (m, IH), 3.96 (m, IH), 3.86 (q, IH), 3.56 (m, IH), 3.19 (dd, IH), 3.09 (m, IH), 3.04 (m, IH), 2.96 (m, 2H), 2.68 (s, 3H), 2.58 (m, IH), 2.45 (m, IH), 2.42 (s, 3H), 2.33 (s, IH), 2.27 (s, 6H), 2.00---1.88 (2H), 1.90 (m, IH), 1.81 (dd, IH), 1.73 (bd, IH), 1.67 (m, IH), 1.60 (m, IH), 1.49 (s, 3H), 1.38 (d, 3H), 1.34 (s, 3H), 1.32 (d, 3H), 1.25 (m, IH), 1.25 (d, 3H), 1.16 (d, 3H), 1.10 (d, 3H), 0.88 (t, 3H). Example 85 fllS.21i?,S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12Jl-roxycarbonyl-(3- (pyridin-3-yl)-propylamino)-methylene1 -erythromycin A A solution of example 7 (0.050g) and intermediate 81 (0.020g) in anhydrous acetonitrile (0.7mL) was stirred at room temperature for 3h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (ImL) then sodium cyanoborohydride (IM in THF, 0.035mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.009g). mVz ([MH] + ) = 746. •■■ H-NMR (CDC1 3 ) δ: 8.47-8.40 (m, 2H), 7.51 (m, IH), 7.19 (m, IH), 4.14 (m, IH), 3.03 (m, IH), 2.98-2.85 (m, 2H), 2.75-2.60 (m, 2H), 2.31 (bm, IH), 1.82-1.76 (m, 2H), 1.09 (d, 3H). Example 86 fll-_>.21-R.S.-3-Decladinosyl-ll-12-dideoxy-6-O-methyl-3-oxo-12,ll-loxycarbonyl-t3-(4- pyridin-2-yl-pyrazol-l-yl)-propylamino)-methylenel-ervthromvcip A A solution of example 7 (0.050g) and intermediate 82 (0.025g) in anhydrous acetonitrile (3mL) was stirred at 50°C for 3h and at room temperature overnight under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2.2mL) then sodium cyanoborohydride (IM in THF, 0.040mL) and acetic acid (0.020mL) were added. After lOh the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.026g). iH-NMR (CDCI3) δ: 8.54 (d, IH), 8.01 (s, IH), 7.98 (s, IH), 7.65 (t, IH), 7.50 (t, IH), 7.07 (m, IH), 4.27 (d, IH), 4.14 (m, 2H), 3.04 (m, IH), 2.89 (m, 2H), 2.34 (m, IH), 2.12 (m, IH), 2.03 (m, IH), 1.09 (d, 3H). Example 87 (llS.21J?.Sl-3-Decladinosyl-11.12-dideoxy-6-O-methvI-3-oxo-12,ll-roxycarbonyl-(3- (pyridin-4-yl)-propylamino)-methylenel -erythromycin A A solution of example 7 (0.050g) and intermediate 83 (0.050g) in anhydrous acetonitrile (ImL) was stirred at room temperature overnight under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (ImL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 24h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 90V10) and by preparative TLC (eluting with: DCMVMeOHVNH 4 OH 90V9V0.5) to give the title compound (0.014g). iH- MR (CDCI3) δ: 8.47 (d, 2H), 7.13 (d, 2H), 5.70 (dd, IH), 4.31 (d, IH), 4.25 (d, IH), 4.14 (s, IH), 3.85 (q, IH), 3.56 (m, IH), 3.18 (dd, IH), 3.10 (m, IH), 3.03 (q, IH), 2.95÷2.83 (m, 2H), 2.65÷2.55 (m, 2H), 2.67 (s, 3H), 2.59 (m, IH), 2.46 (m, IH), 2.3 l(s, IH), 2.27 (s, 6H), 1.91 (m, IH), 1.82÷1.76 (m, 3H), 1.73 (m, IH), 1.68 (m, IH), 1.58 (m, IH), 1.48 (s, 3H), 1.39 (d, 3H), 1.34 (s, 3H), 1.32 (d, 3H), 1.25 (m, IH), 1.25 (d, 3H), 1.15 (d, 3H), 1.09 (d, 3H), 0.87 (t, 3H). Example 88 (ll-y.21i?.-y)-3-DecladinosvI-ll,12-dideoxy-6-0-methyl-3-oxo-12αi-roxycarbonyl-(3-(4- Pyrimidin-4-yl-pyrazol-l-yl)-propylamino)-methylenel-ervthromycin A A solution of example 7 (0.028g) and intermediate 84 (0.018g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 30min then heated to 50°C for 6h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.025mL) and acetic acid (0.004mL) were added. After 24h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100.0 to 97V3) to give the title compound (0.005g). - ■ Η-NMR (CDC1 3 ) δ: 9.09 (d, IH), 8.63 (d, IH), 8.18 (s, IH), 8.07 (s, IH), 7.47 (d, IH), 4.30 (m, 2H), 4.13 (s, IH), 3.04 (m, IH), 2.92-2.80 (m, 2H), 2.33 (m, IH), 2.11 (m, IH), 2.00 (m, IH), 1.09 (d, 3H). Example 89 ril-S l .21i- , ._S , )-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12Jl-roxycarbonyl-(3-f4- pyridin-4-yl-pyrazol-l-vI)-propylamino)-methylenel-ervthromycin A A solution of example 7 (0.050g) and intermediate 85 (0.018g) in anhydrous acetonitrile (2.2mL) was stirred at 50°C for 16h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (3mL) then sodium cyanoborohydride (IM in THF, 0.040mL) and acetic acid (0.020mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a NaHC0 3 saturated aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 95V5) to give the title compound (0.014g). 1H-NMR (CDC1 3 ) δ: 8.55 (d, IH), 7.96 (s, IH), 7.85 (s, IH), 7.42 (d, IH), 4.13 (d, IH), 3.04 (m, IH), 2.89 (m, IH), 2.84 (m, IH), 2.33 (m, IH), 2.10 (m, IH), 1.95 (m, IH), 1.10 (d, 3H). Example 90 fllS l .21 t _ -3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-f3-(4- (3,5-dichloro-phenyl)-2 < 5-dimethyl-imidazoI-l-yl)-propyIaminoVmethylenel- erythromvcin A A solution of example 7 (0.030g) and intermediate 86 (0.029g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 5h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (1.5mL) then sodium cyanoborohydride (IM in THF, 0.022mL) and acetic acid (0.003mL) were added. After 12h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 97V3) to give the title compound (0.022g). iH-NMR (CDCI 3 ) δ: 7.47 (d, 2H), 7.15 (t, IH), 4.11 (m, IH), 3.98 (m, IH), 3.82 (m, IH), 2.93 (m, 2H), 2.38 (s, 3H), 2.33 (s, 3H), 2.29 (m, 1H), 1.6*1.8 (m, 2H). Example 91 (ll-->. 7-R.S.-3-Decladinosyl-ll-12-dideoxy-6-O-methyl-3-oxo-12.11-[oxycarbonyl-(3-f2-5- dimethyl-4-(3-trifluoromethyl-phenyl)-imidazol-l-yl)-propylamino)-methvIenel- ervthromvcin A A solution of example 7 (0.040g) and intermediate 87 (0.042g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 4h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (1.5mL) then sodium cyanoborohydride (IM in THF, 0.030mL) and acetic acid (0.004mL) were added. After 12h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 97V3) to give the title compound (0.026g). •■■ H-NMR (CDCI 3 ) δ: 7.84 (bs, IH), 7.74 (m, IH), 7.43 (m, 2H), 4.12 (s, IH), 3.99 (m, IH), 3.82 (m, IH), 2.9÷2.88 (m, 2H), 2.40 (s, 3H), 2.33 (s, 3H), 2.30 (s, IH), 1.85÷1.75 (m, 2H). Example 92 (llS.21-R.--t)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-t3-r4- (l,3-benzoxazol-2-yl)-lj_- r -pyrazoI-l-vIl-propylamino)-methyIenel-ervthromvcin A A solution of example 7 (0.037g) and intermediate 88 (0.022g) in anhydrous acetonifrile (1.5mL) was stirred at 50°C for 6h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.030mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 97V3) to give the title compound (0.007g). X H-NMR (CDCI 3 ) δ: 8.17 (s, IH), 8.14 (s, IH), 7.68 (dd, IH), 7.51 (dd, IH), 7.29 (m, 2H), 4.34-4.29 (m, 2H), 4.14 (s, IH), 3.03 (m, IH), 2.90 (m, 2H), 2.33 (bm, IH), 2.15 (m, IH), 2.00 (m, IH), 1.09 (d, 3H) Example 93 (HS.21i_.S)-3-Decladinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-f3-(5- Pyridin-4-yl-pyrazol-l-yl -propylamino)-methylenel-ervthromycin A A solution of example 7 (0.050g) and intermediate 89 (0.036g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 20h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.075mL) and acetic acid (O.OlOmL) were added. After 20h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 97V3) to give the title compound (0.01 lg). 1H-NMR (CDCI3) δ: 8.60 (d, IH), 7.69 (d, IH), 7.52 (d, IH), 6.62 (d, IH), 4.29 (m, 2H), 4.14 (m, IH), 3.04 (m, IH), 2.88 (m, 2H), 2.33 (m, IH), 2.20 (m, IH), 1.98 (m, IH), 1.10 (d, 3H). Example 94 (ll_y.21 J g.-y)-3-Decladinosyl-liα2-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-(3-(2- pyridin-4-yl-lH-imidazol-l-yl)-propylamino)-methylenel-erythromvcin A A solution of example 7 (0.050g) and intermediate 90 (0.025g) in anhydrous acetonitrile (2mL) was stirred at 50°C for 6h then at room temperature overnight under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.150mL) and acetic acid (0.006mL) were added. After 72h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 90V10) to give the title compound (0.014g). ■■■ H-NMR (CDCI3) δ: 8. 27 (d, IH), 7.59 (d, IH), 7.19 (m, IH), 7.16 (m, IH), 4.30-4.10 (m, 3H), 3.15 (m, 2H), 2.96 (m, IH), 2.31 (m, IH), 2.00 - 1.82 (m, 2H), 1.09 (d, 3H). Example 95 ril-S'.21i- l .-y)-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbo-nyl-(3-f4- quinolin-2-yl-lH-pyrazol-l-yl -propyIamino)-methylenel-ervthromvcin A A solution of example 7 (0.050g) and intermediate 91 (0.032g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (ImL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 98V2 to 94V6) and by preparative TLC (DCMVMeOHVNH 4 OH 90V9V0.5) to give the title compound (0.018g). 1H-NMR (CDCI 3 ) δ: 8.20 (s, IH), 8.14 (s, IH), 8.12 (d, IH), 8.04 (d, IH), 7.76 (d, IH), 7.67 (t, IH), 7.66 (d, IH), 7.45 (t, IH), 5.68 (dd, IH), 4. 31 (m, 3H), 4.26 (d, IH), 4.15 (s, IH), 3.86 (q, IH), 3.56 (m, IH), 3.18 (dd, IH), 3.11 (m, IH), 3.05 (m, IH), 2.95÷2.80 (m, 2H), 2.70 (s, 3H), 2. 58 (m, IH), 2.46 (m, IH), 2.35 (s, IH), 2.27 (s, 6H), 2.14 (m, IH), 2.06 (m,lH), 1.96 (m, IH), 1.80 (m, IH), 1.74 (m, IH), 1.70 (m, IH), 1.65 (m, IH), 1.50 (s, 3H), 1.40 (d, 3H), 1.34 (s, 3H), 1.32 (d, 3H), 1.25 (m, IH), 1.24 (d, 3H), 1.16 (d, 3H), 1.10 (d, 3H), 0.90 (t, 3H). Example 96 fll-S l .21-R.S)-3-Decladinosyl-11.12-dideoxy-6-Q-methyl-3-oxo-12-ll-roxycarbonyl-(3-(4- quinolin-4-yl-lH-pyrazoI-l-yl)-propylamino)-methylenel-ervthromvcin A A solution of example 7 (0.050g) and intermediate 92 (0.034g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (ImL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 98V2 to 94V6) to give the title compound (0.020g). !H-NMR (CDC1 3 ) δ: 8.89 (d, IH), 8.25 (d, IH), 8.14 (d, IH), 7.87 (s, IH), 7.84 (s, IH), 7.73 (m, IH), 7.59 (m, IH), 7.42 (d, IH), 5.63 (dd, IH), 4.37 (m, 2H), 4.30 (d, IH), 4.24 (d, IH), 4.16 (s, IH), 3.85 (q, IH), 3.55 (m, IH), 3.18 (dd, IH), 3.10 (m, IH), 3.04 (m, IH), 2.94 (m, 2H), 2.70 (s, 3H), 2.58 (m, IH), 2.45 (m, IH), 2.34 (s, IH), 2.27 (s, 6H), 2.19 (m, IH), 2.05 (m, IH), 1.88 (m, IH), 1.80 (dd, IH), 1.73 (m, IH), 1.67 (m, IH), 1.56 (m, IH), 1.49 (s, 3H), 1.38 (d, 3H), 1.33 (s, 3H), 1.32 (d, 3H), 1.25 (m, IH), 1.24 (d, 3H), 1.15(d, 3H), 1.10 (d, 3H), 0.83 (t, 3H). Example 97 (ll-y.21Jϋ._y.-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-r3-(4- quinoxalin-2-yl-lH-pyrazol-l-yl)-propylamino)-methylenel-ervthromycin A A solution of example 7 (0.050g) and intermediate 93 (0.030g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (ImL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 98V2 to 94V6) and by preparative TLC (DCMVMeOHVNH 4 OH 90 9V0.5) to give the title compound (0.006g). iH-NMR (CDC1 3 ) δ: 9.10 (s, IH), 8.28 (s, IH), 8.22 (s, IH), 8.03 (m, 2H), 7.73 (t, IH), 7.66 (t, IH), 5.63 (dd, IH), 4.35 (m, 2H), 4.30 (d, IH), 4.26 (d, IH), 4.15 (m, IH), 3.87 (q, IH), 3.55 ( , IH), 3.17 (m, IH), 3.11 (m, IH), 3.05 (m, IH), 3.00÷2.80 (m, 2H), 2.71 (s, 3H), 2.60 (m, IH), 2.46 (m, IH), 2.35 (m, IH), 2.27 (s, 6H), 2.15 (m, IH), 2.06 (m, IH), 1.96 (m, IH), 1.80 (m, IH), 1.74 (m, IH), 1.68 (m, IH), 1.60 (m, IH), 1.50 (s, 3H), 1.40 (d, 3H), 1.34 (s, 3H), 1.32 (d, 3H), 1.30 (m, IH), 1.24 (d, 3H), 1.16 (d, 3H), 1.10 (d, 3H), 0.90 (t, 3H). Example 98 (llS.21i-.S)-3-Decladinosyl-li 2-dideoxy-6-Q-methyl-3-oxo-12-ll-roxycarbonyl-f3- thien-3-ylpropylamino)-methylenel -erythromycin A A solution of example 7 (0.042g) and intermediate 94 (0.025g) in anhydrous acetonitrile (2mL) was stirred at 50°C for 6h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.035mL) and acetic acid (0.004mL) were added. After 18h at room temperature the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 98V2) to give the title compound (0.012g). ■■■ H-NMR (CDCI 3 ) δ: 7.21 (m, IH), 6.94 (m, 2H), 4.13 (m, IH), 3.03 (m, IH), 2.91 (m, IH), 2.83 (m, IH), 2.80-2.60 (m, 2H), 2.31 (m, IH), 1.80 (m, 2H), 1.09 (d, 3H). Example 99 (H.y.21_g.-_>)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-f3-r5- (3-mithyl-pyrazin-2-yl)-pyrazol-l-yIl-propyIamino)-methvIenel-ervthromvcin A A solution of example 7 (0.050g) and intermediate 95 (0.037g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.075mL) and acetic acid (0.009mL) were added. After 20h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 94V6) to give the title compound (0.018g). !H-NMR (CDCI 3 ) δ: 8.44 (d, IH), 8.36 (d, IH), 7.54 (d, IH), 6.82 (d, IH), 4.40-4.20 (m, 2H), 4.14 (m, IH), 3.04 (m, IH), 2.90 (s, 3H), 2.89 (m, 2H), 2.33 (m, IH), 2.15 (m, IH), 2.05 (m, IH), 1.10 (d, 3H). Example 100 (llS.21i-.S)-3-Decladinosyl-liα2-dideoxy-6-Q-methyl-3-oxo-12Jl-foxycarbonyl-(3-r2- (methylthio)-lH-benzimidazol-l-yll-propylamino)-methylenel-ervthromvcin A A solution of example 7 (0.050g) and intermediate 96 (0.037g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 3h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.075mL) and acetic acid (0.009mL) were added. After 20h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 98V2) to give the title compound (0.020g). - -NMR (CDCI 3 ) δ: 7.66 (m, IH), 7.40 (m, IH), 7.35 (m, IH), 7.20 (m, IH), 4.15 (m, IH), 4.25 (m, IH), 4.13 (m, IH), 3.05 (m, IH), 2.95 (m, 2H), 2.79 (m, 2H), 2.36 (m, IH), 2.00 (m, IH), 1.86 (m, IH), 1.10 (d, 3H). Example 101 (1 lιS'.21R._y)-3-Decladinosyl-l 1.12-dideoxy-6-Q-methyl-3-oxo-12,l 1- f oxycarbonvI-(3- \3- (4-chIorophenyl)-lH-pyrazol-5-yll-propylamino)-methvIene1-ervthromycin A A solution of example 7 (0.040g) and intermediate 97 (0.035g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 12h then heated to 50°C for 6h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (1.5mL) then sodium cyanoborohydride (IM in THF, 0.030mL) and acetic acid (0.004mL) were added. After 12h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100VO to 97V3) to give the title compound (0.017g). --H-NMR (CDC1 3 ) δ: 7.73 (d, 2H), 7.35 (d, 2H), 6.35 (s, IH), 4.15 (m, IH), 2.93 (m, 2H), 2.82 (m, IH), 2.34 (m, IH), 1.88 (m, IH). Example 102 (H-S'.21R.S)-3-DecladinosvI-liα2-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-f3-r6- (methylthio)-7H-purin-7-yll -propylaminoVmethylenel -erythromycin A A solution of example 7 (0.040g) and intermediate 98 (0.042g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 3h then heated to 50°C for 3h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (1.5mL) then sodium cyanoborohydride (IM in THF, O.OβOmL) and acetic acid (0.008mL) were added. After 6h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 98V2) to give the title compound (0.005g). - H-NMR (CDCI 3 ) δ: 8.85 (m, IH), 8.25 (s, IH), 4.63 (m, IH), 4.45 (m, IH), 4.15 (m, IH), 2.97 (m, 2H), 2.76 (s, 3H), 2.33 (m, IH), 2.0÷2.2 (m, 2H). Example 103 (1 l-S'.21l-,-SV3-Decladinosyl-l 1.12-dideoxy-6-O-methyl-3-oxo-12,,l 1- . oxycarbonyl-(3-(6- methoxy-7H-purin-7-yl)-propylamino)-methyIene1-ervthromvcin A A solution of example 7 (0.050g) and intermediate 99 (0.03 lg) in anhydrous acetonitrile (1.5mL) was stirred at room temperature overnight under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (1.5mL) then sodium cyanoborohydride (IM in THF, 0.074mL) and acetic acid (O.OlOmL) were added. After 4h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 97V3) to give the title compound (0.015g). - -NMR (CDC1 3 ) δ: 8.54 (s, IH), 8.07 (s, IH), 5.58 (dd, IH), 4.37 (t, 2H), 4.31 (d, IH), 4.25 (d, IH), 4.19 (s, 3H), 4.13 (bs, IH), 3.86 (q, IH), 3.55 (m, IH), 3.20 (m, IH), 3.10 (m, IH), 3.04 (m, IH), 2.89 (bm, 2H), 2.70 (s, 3H), 2.59 (m, IH), 2.48 (bm, IH), 2.34 (s, IH), 2.29 (s, 6H), 2.12 (m, IH), 2.04 (m, IH), 1.95 (m, IH), 1.85-1.48 (m, 5H), 1.49 (s, 3H), 1.39 (d, 3H), 1.34 (s, 3H), 1.32 (d, 3H), 1.25 (d+m, 3H+1H), 1.16 (d, 3H), 1.10 (d, 3H), 0.89 (t, 3H). Example 104 ril-S l .21i-'.-S , )-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-f3-r6- methoxy-2-oxo-l,3-benzoxazol-3(2ID-yl -propylamino)-methylenel-ervthromvcin A A solution of example 7 (0.043g) and intermediate 100 (0.025g) in anhydrous acetonitrile (2mL) was stirred at room temperature for 30min then heated to 50°C for 6h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.030mL) and acetic acid (0.005mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 97V3) to give the title compound (0.007g). 1H-NMR (CDC1 3 ) δ: 7.05 (d, IH), 6.82 (d, IH), 6.47 (dd, IH), 4.13 (s, IH), 3.87 (m, 2H), 3.81 (s, 3H), 3.04 (m, IH), 2.97-2.92 (m, 2H), 2.34 (m, IH), 1.96 (m, IH), 1.80 (m, IH), 1.09 (d, 3H). Example 105 fll_S l .21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12Jl-roxycarbonyl-f3- H- pyrrolof2.3-blpyridin-l-yl)-propylamino -methylenel-ervthromycin A A solution of example 7 (0.050g) and intermediate 101 (0.042g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 6h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (1.5mL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.005mL) were added. After 8h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH 95V5V0.5) to give the title compound (0.006g). --H-NMR (CDC1 3 ) δ: 8.30 (dd, IH), 7.87 (dd, IH), 7.30 (d, IH), 7.03 (dd, IH), 6.43 (d, IH), 5.71 (dd, IH), 4.44÷4.36 (m, 2H), 4.32 (d, IH), 4.25 (d, IH), 4.13 (s, IH), 3.85 (q, IH), 3.55 (m, IH), 3.22 (dd, IH), 3.11 (m, IH), 3.04 (m, IH), 2.90---2.78 (m, 2H), 2.70 (s, 3H), 2.62÷2.50 (m, 2H), 2.35 (s, IH), 2.32 (s, 6H), 2.06 (m, IH), 2.00 (m,lH), 1.95 (m, IH), 1.80---1.68 (m, 3H), 1.58 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.33 (s, 3H), 1.32 (d, 3H), 1.25 (m, IH), 1.25 (d, 3H), 1.15 (d, 3H), 1.10 (d, 3H), 0.89 (t, 3H). Example 106 (llS.21R.S)-3-Decladinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12.11-foxycarbonyl-(2-(l,3- dioxo-l,3-dihvdro-2H-isoindol-2-yl)-ethylamino)-methylenel-ervthromvcin A To a solution of example 13 (0.232g) in anhydrous DMF (5mL) 2-[(l,3-thiazol-2- ylamino)carbonyl]benzoic acid (0.097g), (benzofriazol-l-yloxy)fripyrrolidinophosphonium hexafluorophosphate (0.186g) and DIPEA (0.120mL) were added and the resulting mixture was stirred overnight at room temperature. It was diluted with DCM (lOmL) and washed with a 5% NaHC0 3 aqueous solution (2x5mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The residue was dissolved in DCM (5mL) loaded on SCX-cartridge (5g, loading 0.75mmolVg, previously washed with 50mL of MeOH), washed with MeOH (50mL), then the product eluted with NH 3 (0.25M solution in MeOH, 60mL), followed by MeOH (lOmL). Solvent evaporation gave the title compound (0.170g). 1H-NMR (CDC1 3 ) δ: 7.80 (m, 2H), 7.67 (m, 2H), 5.53 (dd, IH), 4.30 (d, IH), 4.24 (d, IH), 4.17 (s, IH), 3.84 (m, 2H), 3.74 (m, IH), 3.55 (m, IH), 3.20-3.15 (m, 2H), 3.12-2.88 (m, 3H), 2.63 (s, 3H), 2.54 (m, IH), 2.47 (m, IH), 2.30 (m, IH), 2.27 (s, 6H), 1.86 (m, IH), 1.75-1.65 (m, 3H), 1.48 (m, IH), 1.43 (s, 3H), 1.29 (s, 3H), 1.28-1.24 (m, 2*3H+1H), 1.19 (d, 3H), 1.12 (d, 3H), 1.06 (d, 3H), 0.73 (t, 3H). Example 107 αiS.21R.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12Jl-roxycarbonyl-(3-13- (2,4-dimethyl-l,3-thiazol-5-yl)-lH-pyrazol-l-vn-propylamino)-methvIenel-ervthromycin A A solution of example 7 (0.050g) and intermediate 102 (0.042g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 6h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.070mL) and acetic acid (0.009mL) were added. After 20h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 98V2) to give the title compound (0.016g). 1H-NMR (CDCI3) δ: 7.49 (d, IH), 6.36 (d, IH), 5.62 (dd, IH), 4.31 (d, IH), 4.25 (d, IH), 4.23 (m, 2H), 4.13 (s, IH), 3.85 (q, IH), 3.56 (m, IH), 3.19 (m, IH), 3.10 (m, IH), 3.03 (m, IH), 2.92÷2.82 (m, 2H), 2.69 (s, 3H), 2.66 (s, 3H), 2.58 (m, IH), 2.55 (s, 3H), 2.47 (m, IH), 2.33 (s, IH), 2.28 (s, 6H), 2.08 (m, IH), 1.98 (m, IH), 1.94 (m, IH), 1.80 (m, IH), 1.76÷1.66 (m, 2H), 1.62+1.50 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.34 (s, 3H), 1.32 (d, 3H), 1.25 (m, IH), 1.25 (d, 3H), 1.15 (d, 3H), 1.10 (d, 3H), 0.88 (t, 3H). Example 108 rilS.21 J R.S.-3-Decladinosyl-liα2-dideoxy-6-O-methyl-3-oxo-12,ll-loxycarbonyl-(3-flH- imidazo [4,5-cl pyridin-l-vI)-propylamino)-methyIenel -erythromycin A and Example 109 rilS.21-R.S.-3-DecladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-foxycarbonyl-(3-(3H- imidazo 14,5-cl pyridin-3-yl)-propylamino -methylenel -erythromycin A A solution of example 7 (0.050g) and intermediate 103 (0.034g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by preparative TLC (DCMVMeOHVNH 4 OH 90V9V0.5) to give the title compound 108 (0.008g) and the title compound 109 (0.004g). iH-NMR (CDC1 3 ) δ (example 108): 9.11 (s, IH), 8.44 (d, IH), 8.08 (s, IH), 7.47 (d, IH), 4.41 (m, IH), 4.28 (m, IH), 4.14 (m, IH), 3.05 (m, IH), 3.00-2.90 (m, 2H), 2.31 (m, IH), 2.08 (m, IH), 1.95 (m, IH), 1.09 (d, 3H). iH-NMR (CDCI 3 ) δ (example 109): 8.90 (s, IH), 8.45 (d, IH), 8.16 (s, IH), 7.70 (d, IH), 4.48 (m, IH), 4.37 (m, IH), 4.15 (bs, IH), 3.08 (m, IH), 2.95 (m, IH), 2.33 (m, IH), 2.14 (m, IH), 2.04 (m, IH), 1.09 (d, 3H). Example 110 (115.21_g.S , )-3-Decladmosyl-liα2-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-f3-(lH- benzimidazol-l-yl)-propylamino)-methylenel-ervthromvcin A A solution of example 7 (0.050g) and intermediate 104 (0.025g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 94V6) to give the title compound (0.02 lg). iH-NMR (CDCI 3 ) δ: 8.00 (s, IH), 7.80 (d, IH), 7.48 (d, IH), 7.40-7.20 (m, 2H), 4.38 (m, IH), 4.24 (m, IH), 4.10 (m, IH), 3.05 (m, IH), 3.03 (m, IH), 2.98 (m, IH), 2.32 (m, IH), 2.02 (m, IH), 1.93 (m, IH), 1.09 (d, 3H). Example 111 fllS.21-R.S)-3-Decladinosyl-11.12-dideoxy-6-Q-methyl-3-oxo-12,ll-roxycarbonyl-f3-(3H- imidazo [4,5-61 pyridin-3-yl)-propylamino -methylenel -erythromycin A A solution of example 7 (0.050g) and intermediate 105 (0.034g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 94V6) and by preparative TLC (eluting with: DCMVMeOHVNH 4 OH 90V9V0.5) to give the title compound (0.004g). ■■■ H-NMR (CDC1 3 ) δ: 8.39 (dd, IH), 8.21 (s, IH), 8.05 (dd, IH), 7.22 (dd, IH), 4.43 (t, 2H), 4.15 (m, IH), 3.04 (m, IH), 2.32 (m, IH), 1.10 (d, 3H). Example 112 (llS.21J--.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(3- (quinoxalin-2-ylsulfanyl)-propylamino)-methylenel-ervthromvcin A A solution of intermediate 106 (0.080g) in acetonitrile (3mL) and a 2N HCl aqueous solution (2mL) was heated to 40°C for lh. The reaction mixture was cooled down to room temperature, then it was added dropwise to a solution of example 7 (0.090g) dissolved in anhydrous acetonitrile (3mL) keeping the pH of the solution in the range 6-7 by addition of saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature overnight. Acetic acid was added to the mixture to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.200mL). The reaction mixture was stirred for 5h at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (lOmL) was added and the product was exfracted with DCM (4xl5mL). The organic layer was dried over Na 2 S0 and concenfrated under vacuum. The residue was dissolved in MeOH (4mL) and stirred overnight. After evaporating the solvent the crude material was purified by flash chromatography (eluting with DCMVMeOH from 98V2 to 96V4) affording the title compound (0.050g). mVz ([MH] + ) = 829. 'H-NMR (CDCI 3 ) δ: 8.57 (s, IH), 7.99 (d, IH), 7.96 (d, IH), 7.69 (t, IH), 7.60 (t, IH), 5.71 (dd, IH), 4.32 (d, IH), 4.25 (m, IH), 4.17 (m, IH), 3.84 (q, IH), 3.57 (m, IH), 3.25 (m, IH), 3.50-2.90 (m, 4H), 3.20-2.90 (m, 4H), 2.69 (s, 3H), 2.58 (m, IH), 2.37 (s, 6H), 2.34 (m, IH), 2.10-1.85 (m, 3H), 1.80-1.40 (m, 4H), 1.49 (s, 3H), 1.37 (d, 3H), 1.31 (d, 3H), 1.31 (s, 3H), 1.28 (m, IH), 1.25 (d, 3H), 1.15 (d, 3H), 1.10 (d, 3H), 0.85 (t, 3H). Example 113 f 1 l_y.21-R.S)-3-DecIadinosvI-l l,12-dideoxy-6-O-methyl-3-oxo-12 1- [oxycarbonvI-(3-(4- phenyl-lH-imidazol-l-yl)-propylamino)-methylenel-ervthromvcin A A solution of example 7 (0.050g) and intermediate 107 (0.027g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 4 and concenfrated under reduced pressure. The crude material was purified by preparative TLC (eluting with: DCMVMeOHVNH 4 OH 90V9V0.5) to give the title compound (0.012g). 'H-NMR (CDC1 3 ) δ: 7.79 (d, 2H), 7.56 (m, IH), 7.36 (m, 2H), 7.29 (d, IH), 7.25 (m, IH), 4.32 (m, IH), 4.15 (m, IH), 4.04 (m, IH), 3.05 (m, IH), 3.05-2.95 (m, 2H), 2.33 (m, IH), 1.98 (m, IH), 1.80 (m, IH), 1.09 (d, 3H). Example 114 fllS.21-R.S.-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-[oxycarbonyl-(2-f4- pyridin-4-yl-lH-imidazol-l-yl)-ethylamino)-methylenel-erythromvcin A A solution of intermediate 108 (0.060g) in acetonitrile (1.5mL) and a 3M HCl aqueous solution (1.5mL) was stirred at 70°C for 14h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 7 (0.030g) dissolved in anhydrous acetonitrile (ImL) keeping the pH of the solution in the range 6-7 by addition of a saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature for 4h. Acetic acid was added to the mixture to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.150mL). The reaction mixture was stirred for 72h at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (3mL) was added and the mixture was exfracted with DCM (3x5mL). The organic layer was dried over Na 2 S0 and concentrated under vacuum. The crude material was purified by flash chromatography (eluting with DCMVMeOH from 100V0 to 97V3) and by preparative TLC (eluting with: DCMVMeOH 90V10) to give the title compound (0.004g). iH-NMR (CDCI 3 ) δ: 8.57 (d, 2H), 7.72 (d, 2H), 7.71 (m, IH), 7.60 (m, IH), 5.63 (dd, IH), 4.27 (d, IH), 4.19 (s, IH), 4.18 (d, IH), 4.12 (m, 2H), 3.85 (q, IH), 3.55 (m, IH), 3.32 (m, IH), 3.24 (m, IH), 3.16 (dd, IH), 3.05 (m, IH), 3.03 (m, IH), 2.56 (m, IH), 2.44 (m, IH), 2.41 (s, 3H), 2.27 (s, IH), 2.26 (s, 6H), 1.85 (m, IH), 1.78 (m, IH), 1.70÷1.63 (m, 2H), 1.55 (m, IH), 1.48 (s, 3H), 1.41 (d, 3H), 1.31 (d, 3H), 1.24 (m, IH), 1.24 (d, 3H), 1.23 (s, 3H), 1.14 (d, 3H), 1.09 (d, 3H), 0.81 (t, 3H). Example 115 fllS , .21i?,S)-3-Decladmosyl-liα2-dideoxy-6-0-methyl-3-oxo-12Jl-foxycarbonyl-f2- (quinoxaIin-2-vIsulf anylV ethylamino)- methylenel -erythromycin A A solution of intermediate 109 (0.067 g) in acetonifrile (3mL) and a 2N HCl aqueous solution (2mL) was stirred overnight. Then, the reaction mixture was added dropwise to a solution of example 7 (0.090g) dissolved in anhydrous acetonitrile (3mL) keeping the pH of the solution in the range 6-7 by addition of saturated NaHC0 3 aqueous solution. The reaction mixture was stirred at room temperature for 3h. Acetic acid was added to the mixture to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.200mL). The reaction mixture was stirred for 5h at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (lOmL) was added and the mixture was exfracted with DCM (4xl5mL). The organic layer was dried over Na 2 S0 and concentrated under vacuum. The residue was dissolved in MeOH (4mL) and stirred overnight. After evaporating the solvent the crude material was purified by flash chromatography (eluting with DCMVMeOH from 98V2 to 96V4) to give the title compound (0.076g). mVz ([MH] + ) = 815. 1H-NMR (CDC1 3 ) δ: 8.55 (s, IH), 7.99 (d, IH), 7.93 (d, IH), 7.68 (t, IH), 7.60 (t, IH), 5.68 (dd, IH), 4.32 (d, IH), 4.26 (d, IH), 4.21 (m, IH), 3.83 (q, IH), 3.62-3.48 (m, 3H), 3.23 (m, 2H), 3.19 (dd, IH), 3.10 (m, IH), 3.04 (m, IH), 2.74 (s, 3H), 2.58 (m, IH), 2.48 (m, IH), 2.35 (s, IH), 2.29 (s, 6H), 1.91 (m, IH), 1.80-1.67 (m, 3H), 1.55 (m, IH), 1.49 (s, 3H), 1.35 (d, 3H), 1.30 (d, 3H), 1.34 (s, 3H), 1.26 (m, IH), 1.25 (d, 3H), 1.14 (d, 3H), 1.09 (d, 3H), 0.86 (t, 3H). Example 116 rilS.21_g.S r .-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12,ll-loxycarbonyl-(3-(4- (thiophen-2-yl)-imidazol-l-yl)-propylamino)-methylenel-erythromvcin A A solution of example 6 (0.040g) and intermediate 110 (0.033g) in anhydrous acetonitrile (1.5mL) was stirred at room temperature for 12h. After evaporating the solvent the residue was dissolved in anhydrous MeOH (1.5mL) and sodium cyanoborohydride (IM in THF, 0.030mL) and acetic acid (0.004mL) were added. The reaction mixture was stirred for 12h. The solvent was evaporated under vacuum, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x2mL). The organic layer was dried over Na 2 S0 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with: DCM VMeOH 100V0, 98V2, 97V3) affording the title compound (0.025g). 1H-NMR (CDCI 3 ) δ: 7.52 (d, IH), 7.18 (d, IH), 7.27 (m, IH), 7.16 (d, IH), 7.02 (dd, IH), 5.58 (dd, IH), 4.31 (d, IH), 4.25 (d, IH), 4.14 (m, IH), 4.12 (m, IH), 4.02 (m, IH), 3.86 (q, IH), 3.56 (m, IH), 3.20 (m, IH), 3.10 (m, IH), 3.04 (m, IH), 2.93 (m, 2H), 2.68 (s, 3H), 2.60 (m, IH), 2.50 (m, IH), 2.32 (m, IH), 2.30 (s, 6H), 2.05-1.85 (m, 3H), 1.80 (m, IH), 1.70 (m, 2H), 1.60 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.34 (s, 3H), 1.32 (d, 3H), 1.25 (d+m, 3H+1H), 1.16 (d, 3H), 1.10 (d, 3H), 0.88 (t, 3H). Example 117 (llS,21-_>)-3-DecladinosvI-11.12-dideoxy-6-O-methyl-3-oxo-12Jl-[oxycarbonvI- (3-(4-(thiophen-2-yl)-imidazol-l -vD-prop ylaminoVmethylenel -erythromycin A A solution of example 7 (0.750g) and intermediate 110 (0.300g) in anhydrous acetonitrile (15mL) was stirred at room temperature for 12h. After evaporating the solvent the residue was dissolved in anhydrous MeOH (15mL) and sodium cyanoborohydride (IM in THF, 0.728mL) and acetic acid (0.084mL) were added. The mixture was stirred overnight at room temperature. The solvent was evaporated under vacuum, the crude material dissolved in DCM (50mL) and washed with a saturated NaHC0 3 aqueous solution (2x20mL). The organic layer was dried over Na 2 S0 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with: DCM VMeOH from 95V5 to 90V10) to give the title compound (0.872g, (21S) isomer 95% pure by NMR analysis). iH-NMR (CDC1 3 ) δ: 7.52 (d, IH), 7.18 (d, IH), 7.27 (m, IH), 7.16 (d, IH), 7.02 (dd, IH), 5.58 (dd, IH), 4.31 (d, IH), 4.25 (d, IH), 4.14 (m, IH), 4.12 (m, IH), 4.02 (ro, IH), 3.86 (q, IH), 3.56 (m, IH), 3.20 (m, IH), 3.10 (m, IH), 3.04 (m, IH), 2.93 (m, 2H), 2.68 (s, -OCH 3 ), 2.60 (m, IH), 2.50 (m, IH), 2.32 (m, IH), 2.30 (s, N(CH 3 ) 2 ), 2.05-1.85 (m, 3H), 1.80 (m, IH), 1.70 (m, 2H), 1.60 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.34 (s, 3H), 1.32 (d, 3H), 1.25 (d+m, 3H+1H), 1.16 (d, 3H), 1.10 (d, 3H), 0.88 (t, 3H). Example 118 (1 lS,21-R,-->)-3-Decladinosyl-l l,12-dideoxy-6-O-methyl-3-oxo-12,l 1- [oxycarbonyl-(3-(6- methyl-2-oxo-l,3-benzoxazoI-3(2ID-yl)-propylamino)-methylenel-ervthromvcin A A solution of example 7 (0.050g) and intermediate 111 (0.035g) in anhydrous acetonifrile (2mL) was stirred at 50°C for 6h. After cooling to room temperature solvent was evaporated, the residue dissolved in anhydrous MeOH (2mL) and sodium cyanoborohydride (IM in THF, 0.140mL) and acetic acid (O.OlOmL) were added. The mixture was stirred overnight at room temperature. The solvent was evaporated under vacuum, the residue dissolved in DCM (50mL) and washed with a saturated NaHC0 3 aqueous solution (2x20mL). The organic layer was dried over Na 2 S0 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with: DCM VMeOH from 100V0 to 95V5) affording the title compound (0.020g). 1H-NMR (CDCI 3 ) δ: 7.20-6.80 (m, 3H), 5.66 (dd, IH), 4.38 (d, IH), 4.26 (d, IH), 4.11 (s, IH), 3.88 (m, 3H), 3.67 (m, IH), 3.41 (m, IH), 3.20-2.85 (m, 5H), 2.71 (s, 3H), 2.70 (bs, 6H), 2.59 (m, IH), 2.41-2.35 (m, 1H+ 3H), 2.00-1.55 (m, 7H), 1.50 (s, 3H), 1.39 (d, 1H+3H), 1.32-1.27 (m, 3*3H), 1.18 (d, 3H), 1.10 (d, 3H), 0.88 (t, 3H). Example 119 (ll-S'.21ϋ?.--Λ-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12αi-roxycarbonyl-(2-(2- Pyridin-4-yl-lH-imidazol-l-yl)-ethylamino -methylenel-ervthromycin A A solution of intermediate 112 (0.060g) in acetonifrile (3mL) and a 3M HCl aqueous solution (3mL) was stirred at 80°C for 3 days. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 7 (0.050g) dissolved in anhydrous acetonitrile (2mL) keeping the pH of the solution in the range 6-7 by addition of a saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature for 24h. Acetic acid was added to the mixture to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.070mL). The reaction mixture was stirred for 16h at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (3mL) was added and the product was exfracted with DCM (3x5mL). The organic layer was dried over Na 2 S0 and concentrated under vacuum. The crude material was dissolved in MeOH (ImL) and stirred overnight. After evaporating the solvent the compound was purified by flash chromatography (eluting with DCMVMeOH from 100V0 to 97V3) to give the title compound (0.004g). mVz ([MH] + ) = 798 Example 120 (1 l_y.21i_.S.-3-Decladinosyl-l l-12-dideoxy-6-O-methyl-3-oxo-12 ,11- [oxycarbonyl-(3- f3- (5-cvano-3,4-dimethvIthien-2-yl)-lH-l,2,4-triazol-l-yll-propylamino)-methylenel- ervthromycin A A solution of example 7 (0.050g) and intermediate 113 (0.046g) in anhydrous acetonitrile (2mL) was stirred at room temperature for 18h under nifrogen atmosphere. The solvent was evaporated under reduced pressure, the residue dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.070mL) and acetic acid (0.009mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 94V6) to give the title compound (0.00 lg). X H-NMR (CDC1 3 ) δ: 8.23 (s, IH), 5.51 (dd, IH), 4.38÷4.20 (m, 4H), 4.12(s, IH), 3.86 (m, IH), 3.55 (m, IH), 3.18 (dd, IH), 3.12+3.00 (m, 2H), 2.98÷2.84 (m, 2H), 2.68 (s, 3H), 2.58 (m, IH), 2.52 (s, 3H), 2.44 (m, IH), 2,37 (s, 3H), 2.32 (s, IH), 2.27 (s, 6H), 2.12 (m, IH), 2.02 (m, IH), 1.92 (m, IH), 1.81 (m, IH), 1.74÷1.63 (m, 2H), 1.55 (m, IH), 1.49 (s, 3H), 1.38 (d, 3H), 1.33 (s, 3H), 1.32 (d, 3H), 1.25(m, IH), 1.25 (d, 3H), 1.15(d, 3H), 1.09 (d, 3H), 0.88 (t, 3H). Example 121 (HS.21_g.-_>)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(3- (quinolin-3-yl)-propylamino)-methylenel -erythromycin A A solution of example 7 (0.050g) and intermediate 114 (0.041g) in anhydrous acetonitrile (2mL) was stirred at room temperature for 18h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the residue dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.070mL) and acetic acid (0.009mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 94V6) to give the title compound (0.009g). 1H-NMR (CDCI3) δ: 8.79 (d, IH), 8.07 (d, IH), 7.97 (d, IH), 7.79 (d, IH), 7.65 (t, IH), 7.52 (t, IH), 5.74 (dd, IH), 4.32 (d, IH), 4.25 (d, IH), 4.17 (s, IH), 3.85 (q, IH), 3.55 (m, IH), 3.22 (m, IH), 3.11 (m, IH), 3.04 (m, IH), 3.02÷2.78 (m, 4H), 2.69 (s, 3H), 2.99 (m, IH), 2.52 (m, IH), 2.34 (s, IH), 2.32 (s, 6H), 1.94 (m, IH), 1.89 (m, 2H), 1.88÷1.66 (m, 3H), 1.62+1.50 (m, IH), 1.49 (s, 3H), 1.39 (d, 3H), 1.32 (m, 6H), 1.25 (m, IH), 1.25 (d, 3H), 1.16 (d, 3H), 1.10 (d, 3H), 0.88 (t, 3H). Example 122 (H-S'.21i?.S l .-3-Decladinosyl-li 2-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl-f3-r4- (S-nitrophenvD-lH-imidazol-l-yll-propylamino^-methylenel-erythromvcin A A solution of example 7 (0.050g) and intermediate 115 (0.026g) in anhydrous acetonitrile (ImL) was stirred at room temperature for 18h under nitrogen atmosphere. The solvent was evaporated under reduced pressure, the crude dissolved in anhydrous MeOH (2mL) then sodium cyanoborohydride (IM in THF, 0.037mL) and acetic acid (0.004mL) were added. After 18h the solvent was removed under reduced pressure, the residue dissolved in DCM (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x3mL). The organic phase was dried over Na 2 S0 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 94V6) to give the title compound (0.007g). ■■■ H-NMR (CDC1 3 ) δ: 8.62 (t, IH), 8.17 (d, IH), 8.05 (d, IH), 7.60 (d, IH), 4.15 ( , 2H), 4.09 (m, IH), 4.05 (m, IH), 3.02 (m, IH), 3.04-2.92 (m, 2H), 2.33 (m, IH), 2.05 (m, IH), 1.98 (m, IH), 1.12 (d, 3H). Example 123 fll-->.21-R.-y,-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl-(r2- (2,3-dihydro-l,4-benzodioxin-6-yl ' )pyrrolidin-l-vn -methylenel-ervthromvcm A To a solution of example 7 (O.lOOg) in anhydrous acetonitrile intermediate 117 (0.066g) was added portionwise at room temperature under nifrogen atmosphere. After stirring overnight the solvent was removed under reduced pressure, the residue dissolved in MeOH (2.5mL) and sodium cyanoborohydride (IM in THF, 0.022mL) and acetic acid (0.013mL) added. The mixture was stirred overnight. The solvent was evaporated under vacuum, the residue dissolved in EtOAc (5mL) and washed with a saturated NaHC0 3 aqueous solution (2x2mL) and brine (2mL). The organic layer was dried over Na 2 S0 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with: DCM VMeOH from 100V0 to 97V3) affording the title compound (0.070g). mVz ([MH] + ) = 798 Example 124 (11 '.21i?.S.-3-Decladinosyl-11.12-dideoxy-6-0-methvI-3-oxo-12.11-roxycarbonyl-f3-(5- methoxy-lH-pyrrolo [3,2-bl pyridin-l-yl -propylamino)-methyIenel-ervthromvcin A A solution of intermediate 118 (0.065g) in acetonitrile (2.5mL) and a 3M HCl aqueous solution (2.5mL) was stirred at 60°C for 8h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 7 (0.040g) dissolved in anhydrous acetonitrile (ImL) keeping the pH of the solution in the range 6-7 by addition of a saturated NaHC0 3 aqueous solution. The mixture was stirred at room temperature for 24h. Acetic acid was added to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.060mL). The reaction mixture was stirred overnight at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (3mL) was added and the mixture was exfracted with DCM (3x5mL). The organic layer was dried over Na 2 S0 4 and concentrated under vacuum. The crude material purified by flash chromatography (eluting with DCMVMeOH from 100V0 to 95V5) to give the title compound (0.014g). - •■ H-NMR (CDCI 3 ) δ: 7.66 (d, IH), 7.25 (d, IH), 6.62 (m, IH), 6.51 (d, IH), 4.40 (m, IH), 4.30 (m, IH), 4.15 (m, IH), 4.00 (s, 3H), 3.03 (m, IH), 3.05-2.88 (m, 2H), 2.30 (m, IH), 2.06 (m, IH), 1.96 (m, IH), 1.10 (d, 3H). Example 125 (llS,21i_,S)-3-Decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonvI-(2-r3- (l,3-thiazol-2-yl)-lH-pyrazol-l-yll-ethyIamino)-methylenel-ervthromvcin A A solution of intermediate 119 (0.015g) in acetonifrile (ImL) and a 3M HCl aqueous solution (ImL) was stirred at room temperature for 16h and heated to 50°C for 8h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 7 (0.033g) dissolved in anhydrous acetonifrile (ImL) keeping the pH of the solution in the range 6-7 by addition of saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature overnight. Acetic acid was added to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.0.25mL). The reaction mixture was stirred overnight at room temperature. After evaporating the solvent a saturated NaHCθ 3 aqueous solution (3mL) was added and the mixture was exfracted with DCM (3x5mL). The organic layer was dried over Na 2 S0 4 and concentrated under vacuum. The residue was dissolved in MeOH (ImL) and stirred overnight. After evaporating the solvent the crude material was purified by flash chromatography (eluting with DCMVMeOH from 100V0 to 97V3) and by preparative LC (AVB from 80V20 to 10V90 in 20min) to give the title compound (0.014g). iH-NMR (CDCI 3 ) δ: 7.80 (d, IH), 7.69 (d, IH), 7.27 (d, IH), 6.76 (d, IH), 5.63 (dd, IH), 4.33 (m, 3H), 4.23 (m, 2H), 3.84 (m, IH), 3.57 (m, IH), 3.35 (m, 2H), 3.22 (m, IH), 3.10- 3.00 (m, 2H), 2.64-2.50 (m, 2H), 2.50 (s, 3H), 2.33 (s, 6H), 2.30 (s, IH), 1.90 (m, IH), 1.80- 1.66 (m, 3H), 1.60-1.40 (m+s, 1H+3H), 1.40-1.20 (m, 4*3H+1H), 1.14 (d, 3H), 1.09 (d, 3H), 0.86 (t, 3H). Example 126 (llS,21-R,S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12Jl-loxycarbonyl-(2-(4- phenyl-lH-imidazol-l-yl)-ethylamino)-methylene1-ervthromycin A A solution of intermediate 120 (0.023g) in acetonifrile (0.5mL) and a 3M HCl aqueous solution (0.7mL) was heated to 70°C for 24h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 7 (0.039g) dissolved in anhydrous acetonitrile (0.5mL) keeping the pH of the solution in the range 6-7 by addition of saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature for 6h. Acetic acid was added to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.0.58mL). The reaction mixture was stirred overnight at room temperature. After evaporating the organic solvent the aqueous phase was extracted with EtOAc (3x5mL). The organic layer was washed with brine (3mL), dried over Na 2 S0 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with DCMVMeOH from 97V3 to 95V5) affording the title compound (0,026g). X H-NMR (CDCI 3 ) δ: 7.80 (d, 2H), 7.58 (d, IH), 7.45 (d, IH), 7.36 (t, 2H), 7.21 (m, IH), 4.21 (m, IH), 4.14-4.07 (m, 2H), 3.30-3.20 (m, 2H), 3.07 (m, IH), 2.29 (m, IH), 1.10 (d, 3H). Example 127 (llS.21-f?.S)-3-DecIadinosvI-liα2-dideoxy-6-O-methyl-3-oxo-12αi-roxycarbonyl-(2-(4- thien-2-yl-lH-imidazol-l-yl)-ethylamino)-methylenel-ervthromvcin A A solution of intermediate 121 (0.088g) in acetonifrile (1.5mL) and a 3M HCl aqueous solution (ImL) was heated to 70°C for 24h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 7 (O.lOOg) dissolved in anhydrous acetonitrile (ImL) keeping the pH of the solution in the range 6-7 by addition of saturated NaHC0 3 aqueous solution. The solution was stirred at room temperature for 6h. Acetic acid was added to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.150mL). The reaction mixture was stirred overnight at room temperature. After evaporating the organic solvent the aqueous phase was extracted with EtOAc (3x5mL). The organic layer was washed with brine (3mL), dried over Na 2 S0 4 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with DCMVMeOH from 97\3 to 95\5). The obtained compound was dissolved in MeOH (5mL) stirred overnight at room temperature. After evaporating the solvent, the residue was purified by flash chromatography (eluting with DCMVMeOH from 100V0 to 95V5) to give the title compound (0.034g). 'H-NMR (CDCI 3 ) δ: 7.54 (d, IH), 7.32 (d, IH), 7.28 (dd, IH), 7.15 (dd, IH), 7.01 (dd, IH), 4.20 (m, IH), 4.11-4.07 (m, 2H), 3.30-3.20 (m, 2H), 3.06 (m, IH), 2.30 (m, IH), 1.10 (d, 3H). Example 128 (llS,21R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl- (quinolin-2-ylmethylammo -methylenel-ervthromycin A A solution of example 6 (0.050g) and quinoline-2-carbaldehyde (0.015g) in anhydrous toluene (3mL) was heated to 110°C for 3h. The solution was allowed to reach room temperature and concenfrated under reduced pressure. The residue was dissolved in MeOH (5mL) and palladium palladium (lOwt. % on carbon powder, 0.020g) was added and the mixture stirred under hydrogen atmosphere (1 atm) for lh. Filtration through a celite pad eluting with MeOH (lOmL) and purification by flash chromatography (eluting with DCMVMeOH 90V10) gave the title compound (0.009g). - -NMR (CDC1 3 ) δ: 8.74 (s, IH), 8.30 (d, IH), 8.21 (d, IH), 8.13 (td, IH), 7.83 (t, IH), 7.57 (t, IH), 7.30 (t, IH), 5.16 (bs, IH), 3.12 (m, IH), 2.93 (bs, IH), 1.29 (d, 3H). Example 129 (ll-y.21-R.5)-3-DecIadinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12αi-foxycarbonvI- (quinolin-3-ylmethylaminoV methylenel -erythromycin A A solution of example 6 (0.050g) and quinoline-3-carbaldehyde (0.016g) in anhydrous toluene (3mL) was stirred at 100°C for 15h. After evaporation of the solvent under reduced pressure, the residue was dissolved in MeOH (ImL) and sodium cyanoborohydride (IM in THF, O.OδOmL) and acetic acid (0.004mL) were added. The reaction mixture was stirred overnight at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (3mL) was added and the mixture was exfracted with DCM (3x5mL). The organic layer was dried over Na 2 S0 4 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with DCMVMeOH 94V6) to give the title compound (0.007g). -NMR (CDCI 3 ) δ: 8.94 (d, IH), 8.23 (d, IH), 8.09 (d, IH), 7.82 (d, IH), 7.67 (t, IH), 7.53 (t, IH), 4.29 (d, IH), 4.28 (m, 2H), 4.18 (m, IH), 3.07 (m, IH), 2.48 (m, IH), 1.10 (d, 3H). Example 130 fllS.21i?.S)-3-DecladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12Jl-foxycarbonyl-fN-r3- (4-pyridin-3-yl-lH-iιi-idazol-l-yll-propylacetamido -methylene1-ervthromvcin A To a solution of example 66 (O.OlOg) in anhydrous DCM (0.4mL) DMAP (0.050g) and acetyl chloride (0.030mL) were added portionwise over 4 days. Water (2mL) was added and the mixture was exfracted with DCM (3x5mL). The organic phase was dried over Na 2 S0 4 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with DCMVMeOH from 97.3 to 95V5). The compound was dissolved in MeOH (ImL) and stirred overnight. Solvent evaporation gave the title compound (0.002g). 'H-NMR (CDCI 3 ) δ: 8.97(s, IH), 8.48 (d, IH), 8.07 (d, IH), 7.62 (s, IH), 7.39 (s, IH), 7.31 (m, IH), 5.53 (bm, IH), 4.35 (d, IH), 4.29 (m, IH), 4.15 (m, IH), 4.01 (d, IH), 3.83 (m, IH), 3.72 (q, IH), 3.65 (bs, IH), 3.57-3.52 (m, 3H), 3.21 (m, IH), 3.10 (m, IH), 2.73 (m, IH), 2.65-2.50 (m, 2H+3H), 2.39-2.22 (m, 2H+6H), 2.00 (s, 3H), 1.99 (m, IH), 1.70-1.50 (m, 4H), 1.46 (s, 3H), 1.40 (d, 3H), 1.29-1.23 (m, 7H), 1.26 (s, 3H), 1.10 (d, 3H+3H), 0.95 (t, 3H). Example 131 (llS l ,2lJ?,ι_-)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl- fbenzyl-carbamatel-methylenel-ervthromycin A To a solution of example 7 (0.070g) in anhydrous DCM (2mL) cooled to 0°C TEA(0.090mL), DMAP (catalytic amount) and benzyl chloroformate (0.070g) were added under nifrogen atmosphere. The mixture was stirred at 0°C for 3h. After reaching room temperature a saturated NaHC0 3 aqueous solution (3mL) was added and the mixture was exfracted with DCM (2x5mL). The organic phase was dried over Na2S04 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 100V0 to 98V2). The obtained compound was dissolved in MeOH (ImL) and stirred at room temperature overnight. Solvent evaporation gave the title compound (0.002g). H-NMR (CDCI 3 ) δ: 7.40-7.20 (m, 5H), 5.81 (d, IH), 5.16 (m, IH), 5.08 (m, IH), 4.80 (bm, IH), 3.07 (m, IH), 2.44 (m, IH), 1.18 (d, 3H). Example 132 (ll-S'.2ϋ_.--»)-3-Decladinosyl-11.12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl- ((quinoIin-2-ylmethylene)-amino)-methylene1 -erythromycin A A solution of example 6 (0.050g) and quinoline-2-carbaldehyde (0.015g) in anhydrous toluene (3mL) was heated to 110°C for 3h. The solution was allowed to reach room temperature and concenfrated under reduced pressure. The residue was dissolved in MeOH (5mL) and stirred for 16h. Solvent evaporation gave the title compound (0.050g). X H-NMR (CDCI 3 ) δ: 8.99 (d, IH), 8.47 (d, IH), 8.09 (d, IH), 7.58 (s, IH), 7.41 (s, IH), 7.30 (m, IH), 6.73 (d, IH), 4.88 (dd, IH), 4.67 (s, IH), 3.08 (m, IH), 2.41 (d, IH), 1.16 (d, 3H). Example 133 fll-y.21i-'._y)-3-DecIadinosvI-lia2-dideoxy-2-fluoro-6-0-methyl-3-oxo-12ai- [oxycarbonyl-f2-(quinoxaIin-2-ylsulfanyl)-acetamido)-methylenel-ervthromvcin A To a solution of (quinoxalin-2-ylsulfanyl)-acetic acid (0.056g) in anhydrous DMF (4mL) under a nitrogen atmosphere HATU (0.097g) and DIPEA (0.053mL) were added. The reaction mixture was stirred at room temperature for 20 min then example 11 (0.160g) was added. The reaction mixture was stirred at room temperature for 6h then it was diluted with DCM (lOmL) and washed with a 5% NaHC0 3 aqueous solution (lOmL). The aqueous phase was extracted with DCM (3xl0mL), the combined organic layers washed with a 5% NaHC0 3 aqueous solution (lOmL), dried over Na 2 S0 4 and evaporated under reduced pressure. The residue was dissolved in MeOH (5mL) and stirred at room temperature overnight. After evaporating the solvent the crude material was purified by flash chromatography (DCMVMeOH 95V5) to give the title compound (0.126g). mVz ([MH] + ) = 847 iH-NMR (CDCI 3 ) δ: 8.63 (s, IH), 8.20 (d, IH), 7.99 (m, 2H), 7.72 (t, IH), 7.65 (t, IH), 5.47 (dd, IH), 4.36 (d, IH), 3.98 (s, IH), 3.92 (d, IH), 3.51 (m, IH), 3.16 (m, IH), 3.02 (m, IH), 2.88 (m, IH), 2.64 (s, 3H), 2.58 (m, IH), 2.36 (m, IH), 2.34 (s, 6H 2 ), 2.10 (m, IH), 2.03 (m, IH), 1.97 (m, IH), 1.73 (m, 4H), 1.60-1.40 (m, 8H), 1.23 (m, 4H), 1.15-1.01 (m, 9H), 0.90 (t, 3H). Example 134 (llS.21i?.S)-3-Decladinosyl-liα2-dideoxy-2-flttoro-6-O-methyl-3-oxo-12.11- foxycarbonvI-(4-(2-hvdroxy-4,5-dimethoxy-phenyl)-4-oxo-butyramido -methylene1- ervthromycin A To a solution of 4-(2-hydroxy-4,5-dimethoxy-phenyl)-4-oxo-butyric acid (0.03 lg) in anhydrous DMF (2mL) HATU (0.047g) and DIPEA (0.025mL) were added under nitrogen atmosphere. After stirring for 30min example 10 (0.070g) was added and the mixture stirred overnight. A 5% NaHC0 3 aqueous solution (3mL) was added and the mixture exfracted with DCM (2x3mL). The organic phase was dried over Na 2 S0 and evaporated under reduced pressure. The residue was dissolved in MeOH (3mL) and stirred overnight. After solvent evaporation the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH40H from lOOVOVO to 85V15V0.2) to give the title compound (0.027g). 1 H-NMR (CDC1 3 ) δ:12.46 (s, IH), 7.15 (s, IH), 6.72 (d, IH), 6.44 (s, IH), 4.44 (m, IH), 3.91 (s, 3H), 3.34 (s, 3H), 3.34 (m, 2H), 3.04 (m, IH), 2.70-2.52 (m, 2H), 2.34 (m, IH), 1.80 (d, 3H), 1.17 (d, 3H). Example 135 fllS.21J..S)-3-Decladinosyl-11.12-dideoxy-2-fluoro-6-O-methyl-3-oxo-12,ll- foxycarbonyl-(4-(3,4-dimethoxy-phenyl)-4-oxo-butyramido)-methylenel-ervthromvcin A To a solution of 4-(3,4-dimethoxy-phenyl)-4-oxo-butyric acid (0.029g) in anhydrous DMF (2mL) HATU (0.047g) and DIPEA (0.025mL) were added under nitrogen atmosphere. After stirring for 30min example 10 (0.070g) was added and the mixture stirred overnight. A 5% NaHC0 3 aqueous solution (3mL) was added and the mixture extracted with DCM (2x3mL). The organic phase was dried over Na 2 S0 4 and evaporated under reduced pressure. The residue was dissolved in MeOH (3mL) and stirred overnight. After solvent evaporation the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH40H from lOOVOVO to 85V15V0.2) to give the title compound (0.024g). 1H-NMR (CDC1 3 ) δ: 7.64 (d, IH), 7.53 (m, IH), 6.89 (d, IH), 6.77 (d, IH), 4.40 (t, IH), 3.96 (s, 3H), 3.94 (s, 3H), 3.35 (m, 2H), 3.04 (m, IH), 2.70-2.55 (m, 2H), 2.34 (m, IH), 1.81 (d, 3H), 1.17 (d, 3H). Example 136 tllS l .21R.S)-3-DecIadinosyl-11.12-dideoxy-2-fluoro-6-O-methvI-3-oxo-12,ll- [oxycarbonyl-(4-(4-methoxy-3-nitro-phenyl)-4-oxo-butyramido)-methylene1- erythromycin A To a solution of 4-(4-methoxy-3-nitro-phenyl)-4-oxo-butyric acid (0.03 lg) in anhydrous DMF (2mL) HATU (0.047g) and DIPEA (0.025mL) were added under nifrogen atmosphere. After stirring for 30min example 10 (0.070g) was added and the mixture stirred overnight. A 5% NaHC0 3 aqueous solution (3mL) was added and the mixture exfracted with DCM (2x3mL). The organic phase was dried over Na 2 S0 4 and evaporated under reduced pressure. The residue was dissolved in MeOH (3mL) and stirred overnight. After solvent evaporation the crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH40H from lOOVOVO to 85V15V0.2) to give the title compound (0.030g). 1H-NMR (CDCI 3 ) δ: 8.49 (d, IH), 8.20 (dd, IH), 7.15 (d, IH), 6.66 (d, IH), 4.40 (t, IH), 4.04 (s, 3H), 3.31 (m, 2H), 2.99 (m, IH), 2.73 (m, IH), 2.61 (m, IH), 2.18 (m, IH), 1.18 (d, 3H). Example 137 (HS.21i-.-S , )-3-Decladinosyl-liα2-dideoxy-2-fluoro-6-0-methyl-3-oxo-12 i- [oxycarbonyl-(2-(4-(pyridin-3-yl)-lH--j----idazol-l-yl)-ethvIamino)-methylenel- erythromycin A A solution of intermediate 51 (0.070g) in acetonitrile (2.5mL) and a 3M HCl aqueous solution (2.5mL) was heated to 80°C for 24h. The reaction mixture was allowed to reach room temperature, then it was added dropwise to a solution of example 10 (0.070g) dissolved in anhydrous acetonitrile (2mL) keeping the pH of the solution in the range 6-7 by addition of a saturated NaHC0 3 aqueous solution. The mixture was stirred at room temperature overnight. Acetic acid was added to reach pH 5-6 followed by sodium cyanoborohydride (IM in THF, 0.150mL). The reaction mixture was stirred overnight at room temperature. After evaporating the solvent a saturated NaHC0 3 aqueous solution (3mL) was added and the mixture was exfracted with DCM (2x5mL). The organic layer was dried over Na 2 S0 4 and concenfrated under vacuum. The crude material was purified by flash chromatography (eluting with DCMVMeOHVNH 4 OH from lOOVOVO to 80V20V0.2) to give the title compound (0.006g). iH-NM (CDC1 3 ) δ: 9.05 (d, IH), 8.44 (d, IH), 8.13 (m, IH), 7.65 (d, IH), 7.57 (d, IH), 7.27 (m, 2H), 4.20-4.10 (m, 2H), 4.07 (bs, IH), 3.40-3.25 (m, 2H), 2.87 (m, IH), 2.32 (m, IH), 1.81 (d, 3H), 1.08 (d, 3H). Example 138 fllS.21R.S)-3-Decladinosyl-11.12-dideoxy-2-fluoro-6-Q-methyl-3-oxo-12Jl- roxycarbonyl-(3-(4-(pyridin-3-vI)-imidazol-l-yl)-propyIamino)-methyleneI-ervthromvcin A A solution of example 10 (0.070g) and intermediate 52 (0.035g) in anhydrous acetonitrile (3.5mL) was stirred at room temperature for 6h. After evaporating the solvent the residue was dissolved in anhydrous MeOH (3mL) and sodium cyanoborohydride (IM in THF, 0.05 ImL) and acetic acid (0.008mL) were added. The mixture was stirred overnight. The solvent was evaporated under vacuum, the residue dissolved in DCM (lOmL) and washed with a saturated NaHC0 3 aqueous solution (2xl0mL). The organic layer was dried over Na 2 S0 and concenfrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOHVNH 4 OH from lOOVOVO to 80V20V0.2) to give the title compound (0.012g). mVz ([MH] + ) = 830. iH-NMR (CDCI 3 ) δ: 8.99 (d, IH), 8.46 (dd, IH), 8.11 (dd, IH), 7.63 (s, IH), 7.40 (s, IH), 7.30 (m, IH), 5.45 (dd, IH), 4.42 (d, IH), 4.18 (m, IH), 4.08 (m, IH), 4.04 (m, IH), 3.55 (m, IH), 3.18 (dd, IH), 3.11 (m, IH), 3.00 (m, IH), 2.92 (m, IH), 2.95 (s, 3H), 2.95 (m, IH), 2.58 (m, IH), 2.52 (m, IH), 2.30 (s, 6H), 1.95 (m, 2H), 1.83 (d, 3H), 1.57 (d, 3H), 1.7 (m, IH), 1.68 (m, IH), 1.60 (m, IH), 1.33 (s, 3H), 1.26 (s, 3H), 1.25 (m, IH), ), 1.25 (d, 3H), 1.16 (d, 3H), 1.09 (d, 3H), 0.92 (t, 3H). Example 139 ril-S'.21J?. , )-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-(f2- methvI-6-nitrophenyl)-ureido)-2-ethylamino)-methylenel-ervthromvcin A To a solution of example 13 (0.039g) in anhydrous DCM (2mL) cooled to -10°C a solution of 6-methyl-2-nifroisocyanate (O.OlOg) in anhydrous DCM (2mL) was added and the mixture was stirred at -10°C for 2h. The reaction mixture was quenched with a saturated NaHC0 3 aqueous solution (2mL), the aqueous phase was exfracted with DCM (2mL). The organic phase was dried over Na 2 S0 4 and concentrated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH from 97V3 to 95V5) to give the title compound (O.OlOg). 1H-NMR (CDCI 3 ) δ: 7.97 (bs, IH), 7.78 (d, IH), 7.44 (d, IH), 7.15 (t, IH), 6.23 (bs, IH), 4.22 (s, IH), 3.45 (m, IH), 3.26-3.19 (m, 2H), 3.08 (m, IH), 2.91 (m, IH), 2.32 (s, IH), 1.12 (d, 3H). Example 140 (llS.21i.)-2 , -O-Acetyl-3-DecladinosvI-11.12-dideoxy-6-O-allyl-3-oxo-12αi- foxycarbonyl-(cvano)-methvIenel-ervthromvcin A To a solution of intermediate 38 (0.33g) in DCM (30mL) Dess-Martin periodinane (0.300g) was added portionwise within 3h. A Na 2 S 2 0 3 solution (5% in a saturated NaHC0 3 aqueous solution, 20mL) was added and the mixture was stirred for lh. The aqueous phase was exfracted with DCM (2x50mL), the organic phase was washed with water (2x30mL), dried over Na 2 S0 and evaporated under reduced pressure. Purification of the crude material by flash chromatography (eluting with: DCMVMeOHVNH 3 9.6V0.3V0.09) gave the title compound (0.13g). H-NMR (CDCI 3 ) δ: 5.69 (m, IH), 5.43 (dd, IH), 5.09 (m, 2H), 4.75 (m, IH), 4.73 (s, IH), 4.47 (d, IH), 4.39 (d, IH), 3.91 (q, IH), 3.70 (m, 2H), 3.63 (m, IH), 3.21 (m, IH), 3.20 (s, IH), 3.12 (m, IH), 2.70 (m, IH), 2.65 (m, IH), 2.26 (s, 6H), 2.04 (s, 3H), 1.94 (m, IH), 1.70 (m, IH), 1.65 (m, IH), 1.60 (s, 3H), 1.55 (m, IH), 1.36 (d, 3H), 1.33 (s, 3H), 1.26 (d, 6H), 1.13 (d, 3H), 1.06 (d, 3H), 0.93 (t, 3H). Example 141 (1 l-_».21-R)-3-Decladinosyl-l l,12-dideoxy-6-0-allyl-3-oxo-12,l 1- [ oxycarbonyl-(cvano - methylenel -erythromycin A A solution of example 140 (0.005g) in MeOH (0.5mL) was stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.003g). iH-NMR (CDCI 3 ) δ: 5.71 (m, IH), 5.44 (dd, IH), 5.08 (m, 2H), 4.72 (s, IH), 4.43 (d, IH), 4.40 (d, IH), 3.94 (q, IH), 3.72 (m, 2H), 3.62 (m, IH), 3.20 (m, 4H), 2.68 (m, IH), 2.52 (m, IH), 2.29 (s, 6H), 1.94 (m, IH), 1.81 (m, IH), 1.65 (m, IH), 1.60 (m, IH), 1.61 (s, 3H), 1.42 (d, 3H), 1.35 (s, 3H), 1.34 (d, 3H), 1.26 (d, 3H), 1.12 (d, 3H), 1.08 (d, 3H), 0.93 (t, 3H). Example 142 (ll-->.21i_.-y.-2 , -O-Acetyl-3-decladinosvI-ll,12-dideoxy-6-O-allyl-3-oxo-12,ll- foxycarbonyl-(benzhvdrylideneamino)-methylenel-erythromvcin A To a solution of intermediate 42 (0.528g) and EDC (0.35g) in DCM anhydrous (40mL) cooled to 0°C, DMSO (0.4mL) was added. After 10 min at 0°C, a solution of pyridinium trifluoroacetate (0.36g) in DCM (2mL) was slowly added. After lOmin the ice bath was removed. Two further additions of EDC (0.35g each time), DMSO (0.4mL each time) and pyridinium trifluoroacetate (0.36g each time) were performed. The reaction mixture was quenched with water (50mL) and extracted with DCM (3x50mL). The organic layer was dried over Na 2 S0 4 and concentrated under vacuum to give the title compound (0.520g). TLC: DCMVMeOHVNH 3 20V2V0.2 (Rf=0.39). Example 143 (llS.21i?.S)-2 , -O-Acetyl-3-decladinosyl-11.12-dideoxy-6-O-allyl-3-oxo-12Jl- foxycarbonvI-(amino)-methylenel-ervthromvcin A A solution of example 142 (0.52g) in acetonitrile (66mL) and 1.2N HCl aqueous solution (154mL) was stirred at room temperature for lh. After neutralising the mixture with solid Na 2 C0 3 and evaporating the solvent under vacuum, the mixture was exfracted with DCM (3x50mL). The organic layer was dried over Na 2 S0 4 and concenfrated under reduced pressure to give the title compound (0.47g). 1H-NMR (CDC1 3 ) δ: 5.88 (dd, IH), 5.70 (m, IH), 5.13 (d, IH), 4.75 (m, IH), 4.57 (s, IH), 4.44 (d, IH), 4.38 (d, IH), 3.91 (q, IH), 3.75 (q, dd), 3.61 (m, IH), 3.50 (m, IH), 3.24 (m, IH), 3.08 (m, IH), 2.70 (m, IH), 2.64 (m, IH), 2.46 (bs, IH), 2.26 (s, 6H), 2.18 (m, 6H), 1.60-1.40 (m, 5H), 1.40-1.20 (m, 13H), 1.15 (d, 3H), 1.08 (d, 3H), 0.88 (t, 3H). Example 144 (1 lS.21jR,i_>)-3-DecladinosvI-l l,12-dideoxy-6-O-allyl-3-oxo-12,l 1- roxycarbonvHaminoV methylenel-ervthromvcin A A solution of example 143 (0.002g) in MeOH (0.3mL) was stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.002g). 1H-NMR (CDCI 3 ) δ: 5.82 (dd, IH), 5.73 (m, IH), 5.14 (d, IH), 5.02 (d, IH), 4.54 (s, IH), 4.40 (d, IH), 4.38 (d, IH), 3.93 (q, IH), 3.76 (m, IH), 3.62 (m, IH), 3.52 (m, IH), 3.24 (m, IH), 3.21 (m, IH), 3.09 (m, IH), 2.66 (m, IH), 2.50 (m, IH), 2.47 (m, IH), 2.28 (s, 6H), 1.95 (m, IH), 1.85 (m, 2H), 1.80-0.80 (several m, 27H). mVz ([MH] + ) = 653. Example 145 fllS.21i_ .-3-DecIadinosvI-11.12-dideoxy-6-O-methyl-3-oxo-12qi-roxycarbonvI-f2- (quinolin-2-yIsulf anylV ethylaminoVmethylenel -erythromycin A To a solution of quinolin-2-thiol (0.008g) in anhydrous DMF (0.500mL) sodium hydride (1.2mg) was added and the mixture stirred at room temperature for 15min then intermediate 24 (0.025g) was added and the reaction mixture stirred at 60°C for 5h. The reaction mixture was diluted with DCM (3mL) and washed with a saturated NaHC0 3 aqueous solution (ImL). The organic phase was dried over Na 2 S0 4 and evaporated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 98V2) to give a compound that was dissolved in MeOH (ImL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (O.OlOg). LCVMS analysis (mobile phase: AVB from 90V10 to 10V90 in 10 min, 10V90 for 2 min, mass range 150-1300 amu): retention time: 8.7 min, mVz ([MH] + ) =815. Example 146 (llS.2J-R.-y.-3-DecladinosyI-llJ2-dideoxy-6-O-methyI-3-oxo-12,ll-roxycarbonyl-f2- (benzothiazol-2-ylsulfanyl)-ethylamino)-methylene1-ervthromvcin A To a solution of benzothiazole-2-thiol (0.009g) in anhydrous DMF (0.500mL) sodium hydride (1.2mg) was added and the mixture stirred at room temperature for 15min then intermediate 24 (0.025g) was added and the reaction mixture stirred at 60°C for 5h. The reaction mixture was diluted with DCM (3mL), washed with a saturated NaHC0 3 aqueous solution (ImL). The organic phase was dried over Na 2 S0 4 and evaporated under reduced pressure. The crude material was purified by flash chromatography (eluting with: DCMVMeOH 98V2) to give a compound that was dissolved in MeOH (ImL) and stirred at room temperature overnight. Solvent evaporation under reduced pressure gave the title compound (0.012g). LCVMS analysis (mobile phase: AVB from 90V10 to 10V90 in 10 min, 10V90 for 2 min, mass range 150-1300 amu): retention time: 8.5 min, mVz ([MH] + ) =821. Example 147 3-Pyridin-3-yl-acrvIamide of (llS.21-R.S)-3-decIadinosyl-11.12-dideoxy-6-0-methvI-3- oxo-12,ll-foxycarbonyl-(amino)-methvIenel-ervthromycin A To 3-pyridin-3-yl-acrylic acid (1.3mg) a solution of HATU (0.003g) in anhydrous DMF (0.050mL) and DIPEA (0.002mL) in anhydrous DMF (0.050mL) were added, followed by a solution of example 6 (0.005g) in anhydrous DMF (0.050mL). The reaction mixture was stirred at room temperature for 18 h, then it was diluted with DCM (0.350mL), washed with a 5% NaHC0 3 aqueous solution (0.300mL), then passed through a phase-separation syringe. The aqueous phase was exfracted with DCM (0.250mL) and the collected organic extracts evaporated under vacuum. The crude material was dissolved in DCM (OJOOmL), loaded on SCX-cartridge (250mg, loading 0.28mmol/g, previously washed with 4mL of MeOH), washed with MeOH (3.5mL), then the product eluted with NH 3 (0.25M solution in MeOH, ImL), followed by MeOH (0.7mL). The collected fractions were left in the NH 3 /MeOH solution overnight. After evaporating the solvent the title compound (0.002g) was obtained. LC/MS analysis (mobile phase: A/B from 90/10 to 10/90 in 10 min, 10/90 for 5 min; mass range 150-1200 amu): retention time: 5 min, mVz ([MH] + ) = 758. Examples 148-312: Example 148 3-Benzo 11,31 dioxoI-5-yl-acrylamide of (llS.21-R.-y)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel-ervthromvcin A Example 149 (4-Methyl-2-oxo-2H-chromen-7-vIoxy)-acetamide of (HS,21R.--»)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methvIenel-ervthromycin A Example 150 r(Turan-2-carbonyl)-aminol-acetamide of (HS.21R.S)-3-decladinosvI-ll 2-dideoxy-6- 0-methyl-3-oxo-12,ll-foxycarbonyl-(amino -methylenel-erythromvcin A Example 151 3-(Thiophen-2-yIsulf anvD-pr opionamide of (1 IS, 2 lR.S)-3-decIadinosyl-l 1 ,12-dideoxy-6- O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 152 (Benzofl,31dioxol-5-vIamino)-phenyl-acetamide of (llιS'.21i? t -y)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyI-(amino)-methylenel-ervthromycin A Example 153 { f 3-(2-Chloro-phenylV 5-methyl-isoxazole-4-carbonyl. -aminol-acetamide of (HS,21-g.S)-3-decladinosyl-li 2-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl- (amino)-methylenel -erythromycin A Example 154 2-Acetylamino-3-(6-methvI-lH-indol-3-yl -propionamide of (1 lS.21_R.-S')-3-decladinosyl- m2-dideoxy-6-O-methvI-3-oxo-12 l-[oxycarbonyl-(amino)-methylenel-ervthromycin A Example 155 2-Acetylamino-3-(5-methyl-lH-indol-3-yl)-propionamide of (115 l .21_?._y)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromycin A Example 156 (E)-3-(2.3-Dimethoxy-pyrimidin-5-yl)-acrylamide of fll , .21R.S)-3-decIadinosvI-11.12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-famino)-methylenel-ervthromycin A Example 157 f5-(2-Methoxy-phenyl)-4-phenyl-4J-- r -fl,2,41triazol-3-ylsulfanyll-acetamide of (llS.21_R.S)-3-decladinosyl-liα2-dideoxy-6-0-methyl-3-oxo-12Jl-roxycarbonyl- (aminoVmethylenel-erythromycin A Example 158 2-(4-Methyl-[l-2-31thiadiazol-5-ylsulfanyl -propionamide of (llS.21ig,S)-3-decladinosyl- ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-erythromvcin A Example 159 (7-Methyl-thienor3.2-^pyrimidin-4-ylsulfanvn-acetamide of i_y.21i?.-y)-3-decIadinosvI- ll-12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonvI-(amino -methylenel-erythromycin A Example 160 f5-(2-Chloro-phenvI)-pyrimidin-4-vIsulfanvIl-acetamide of (ll-y.21-R,-y)-3-decIadinosvI- ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-erythromvcin A Example 161 f4-Methyl-5-ouinolin-6-yl-4H-H.2-41triazol-3-ylsulfanyl -acetamide of (llS,2LR.S,-3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12 l-foxycarbonyl-(amino)-methylenel- erythromycin A Example 162 f (5-Bromo-fur an-2-carbonyI)-aminol-acetamide of (1 IS, 2 li?,-y)-3-decladinosyl- 11,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(ami-tto)-methyIenel-erythromvcin A Example 163 f(Thiophene-2-carbonyI -aminol-acetamide of (ll-_».21-R,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino -methylenel-erythromvcin A Example 164 t4-Hvdroxy-2-methyl-pyridin-3-yloxy)-acetamide of (ll-y.21-R,-y)-3-decIadinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-erythromvcin A Example 165 3-QH-Indol-3-yl)-aerylamide of ( 1 l-S.21-ft.-y)-3-decladinosyl-l l,12-dideoxy-6-Q-methyl- 3-oxo-12,ll-Foxycarbonyl-(amino -methyIenel-ervthromvcin A Example 166 4-Oxo-4-thiphen-2-yl-butyramide of (llS.21i?.-y)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-erythromvcin A Example 167 4-(4,5-Dimethoxy-2-nitro-phenyl)-4-oxo-butyramide of (ll-S',21-R.-S , )-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-erythromvcin A Example 168 4-(2-Methoxy-phenyl)-4-oxo-butyramide of (ll-S',21-R,S)-3-decladinosyl-ll,12-dideoxy-6- O-methvI-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 169 4-Oxo-4-pyridin-3-yl-butyramide of (ll-_>,2L-?,ιS r )-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino -methylenel-ervthromvcin A Example 170 4-(4-Methylsulfanyl-phenyl)-4-oxo-butyramide of (ll_y.21_g.S.-3-decladinosyl-11.12- dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-(amino)-methylene1-erythromvcin A Example 171 3-(lH-Imidazol-4-yl)-acrylamide of (llS.21-g.S.-3-decIadmosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonvI-(amino)-methvIenel-erythromvcin A Example 172 4-Thien-2-yl- butyramide of (11 '.21i?. t yi-3-decIadinosvI-11.12-dideoxy-6-0-methyl-3- oxo-12.11-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 173 3-(lH-Indol-3-yl)-propionamide of (llS.21-R.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 174 (Pyridin-4-ylsulfanyl)-acetamide of (llS,21R,-->)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 175 (Pyrimidin-2-ylsulfanyl)-acetamide of (ll-->.21-R.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-roxycarbonvI-(amino)-methylenel-ervthromycin A Example 176 [(Pyridine-3-carbonvπ-aminol-acetamide of (ll--».21-R,-S r .-3-decladinosyl-ll,12-dideoxy- 6-O-methvI-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 177 (Z)-3-Pyridin-4-vI-acrylamide of (llS.21i?.S.-3-decladinosyl-11.12-dideoxy-6-O-methyl- 3-oxo-12.11-foxycarbonyl-(amino -methylenel-ervthromycin A Example 178 f_g)-3-Pyridin-4-yl-acrylamide of QlS.21ig.S)-3-decladinosyl-11.12-dideoxy-6-O-methyl- 3-oxo-12.11-[oxycarbonyl-(amino)-methvIenel-ervthromycin A Example 179 r2-(6-Methyl-pyridin-2-yl)-l-phenyl-ethvIsulfanvn-acetamide of (HS.21-R.S)-3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-(amino ' .-methylene1- erythromycin A Example 180 f (4-Oxo-4H-chromene-2-carbonylV aminol-acetamide of (1 IS.2 l_R.>S l )-3-decladinosyl- ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonvI-(amino -methylenel-ervthromycin A Example 181 3-Q.4-Dioxo-3.4-dihvdrophthalazin-2(l-ffi-ylVpropionamide of (HS.21i?.S)-3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel- erythromycin A Example 182 (4-Methyl-fl.2.31thiadiazol-5-ylsulfanylVacetamide of (llS.21R.S)-3-decladinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 183 (Benxothiazol-2-ylsulfanylVacetamide of (llS.21i_.S.-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromycin A Example 184 3-(lH-Imidazol-4-yl)-propionamide of (llS.21-g.--»)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromycin A Example 185 3-Pyridin-3-yl-propionamide of (ll-S',21-R.--t)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromvcin A Example 186 f(4-Methoxy-quinoline-2-carbonyl -aminol-acetamide of (HS.21i?.S)-3-decladinosyl- ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyI-(amino)-methylenel-ervthromvcin A Example 187 (3-Phenyl- [1 ,2,41 oxadiazol-5-ylamino)-acetamide of (1 IS.2 li_,S)-3-decladmosyl-l 1,12- dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylene1-ervthromvcin A Example 188 14-f 6-Oxo-l ,4,5,6-tetr ahydro-pyridazin-3-yl)-phenoxyl -acetamide of (11S.2 lR,S)-3- decIadinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel- erythromycin A Example 189 3-(5-Methyl-lH-indol-3-vf.-propionamide of (llS.21-R.S.-3-decIadinosyl-11.12-dideoxy- 6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methvIenel-ervthromvcin A Example 190 4-(2.3-dioxo-2,3-dihvdro-lH-indol-5-vn-butyramide of (llS.21R.S)-3-decladinosyl- 1 l,12-dideoxy-6-O-methyl-3-oxo-12,l 1- roxycarbonyl-(amino -methyIenel -erythromycin A Example 191 3-(l,3,8-Trimethyl-2,4,7-trioxo-1.2.3,4,7,8-hexahydropteridin-6-yl)-propionamide of (llS.21i-,ιy)-3-decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12,ll- oxycarbonyl- (amino -methylenel -erythromycin A Example 192 3-(4-Oxo-4,7-dihvdro-3H-pyrrolor2,3-dlpyrimidin-5-yl)-propionamide of (HS.21_R,S)-3- decladinosyl-ll,12-dideoxy-6-0-methvI-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel- erythromycin A Example 193 f4-(l,3-Dimethyl-6-oxo-2-thioxo-2,3,6,9-tetrahvdro-l-H-purin-8-vI)-phenoxyl-acetamide of (115'.21i?;.-_* , .-3-decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl- (amino)-methylenel -erythromycin A Example 194 2-Benzoylamino-3-(lH-indoI-3-yl)-propionamide of (HS,21R,S)-3-decIadinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 195 3-Phenyl-4-(pyridin-2-ylcarbamoyl -butyramide of (llι-f.21i_,S)-3-decIadinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(aminoVmethylenel-ervthromvcin A Example 196 3-Benzo 11 ,31 dioxol-5-yl-2-benzoylamino-acrylamide of (1 IS, 2 lR,S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonvI-(amino)-methvIenel-ervthromycin A Example 197 3-(3-PhenvI-ureido -3-thiophen-3yl-propionamide of (llS.21-R,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 198 3-(Furan-2-yl)-propionamide of (llS,21R.S)-3-decIadinosyl-ll,12-dideoxy-6-0-methyl- 3-oxo-12,ll-[oxycarbonyl-(amino)-methylene1-erythromvcin A Example 199 2-Hvdroxy-3-flH-indol-3-yl)-propionamide of (llS.21-R.S)-3-decIadinosyl-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel-ervthromvcin A Example 200 3-(5-Phenyl-lH-pyrrol-2-ylVpropionamide of (llS,21R,S)-3-decladinosyl-11.12-dideoxy- 6-O-methyl-3-oxo-12,ll-[oxycarbonvI-(amino)-methylenel-ervthromvcin A Example 201 4-Oxo-4-thiophen-2-yl-butyramide of (llS,2LR,S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12.11-roxycarbonyl-(amino)-methylenel-ervthromycin A Example 202 (4-Methyl-pyrimidin-2-ylsulfanyl)-acetamide of (llS.2IR.S)-3-decladinosyl-11.12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel-ervthromvcin A Example 203 4-r2-(l,3-Dioxo-l,3-dihvdro-2g-isoindol-2-yl)-phenyll-butyramide of (11S.21-R.S1-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel- erythromycin A Example 204 4-f2-Methyl-l-oxo-l,2-dihvdroisoquinoUn-3-yl)-butyramide of fllS.21R.S)-3- decIadinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel- erythromycin A Example 205 3-ι3-(4-Methoxyphenyl.-l,2,4-oxadiazol-5-yll-propionamide of (llS.21-g.--».-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylene1- erythromycin A Example 206 (4.6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetamide of (1 lS.21i-'.--t)-3-decladinosvI-l 1.12- dideoxy-6-0-methyl-3-oxo-12,ll-foχycarbonyl-(amino)-methvIenel-ervthromvcin A Example 207 3-(2-Oxo-l,3-benzoxazol-3(2---->yl)-propionamide of (HS.21R.iS f )-3-decIadinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyI-(amino -methylenel-erythromvcin A Example 208 4-(l,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahvdro-lH-purin-8-yl -butyramide of (11S,21R,S)- 3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino - methylenel -erythromycin A Example 209 2-Formylamino-2-(lH-indol-3-yl)-propionamide of (llS'.21-R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcm A Example 210 4-Methyl-2-[(2-methylsulfanyl-pyridine-3-carbonyl)-aminol-pentanamide of (ll-_>.21i-!,S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl- (amino)-methylenel -erythromycin A Example 211 t3.5,6-Trichloro-pyridin-2-vIoxy)-acetamide of (llS.21R.S,-3-decladmosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 212 (5-Phenyl-pyrimidm-2-vIsulfanyl)-acetamide of (ll-->,21-R.-y)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 213 3-(6-Bromo-benzo[l,31dioxol-5-yl)-2-cvano-acrylamide of (HS,21-R,-_>)-3-decladinosyl- ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 214 3-f3-(4-Nitrophenyl)-l,2,4-oxadiazol-5-yll-propionamide of (llS.21i_.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 215 3-(l,3-Benzothiazol-2-yl -propionamide of (HS.21_g.--> r )-3-decladinosvI-ll,12-dideoxy-6- O-methyl-3-oxo-12,ll-[oxycarbonyl-famino)-methvIenel-ervthromvcin A Example 216 3-(3-Pyridin-2-yl-l,2,4-oxadiazol-5-yl -propionamide of (HS,21-R.--»)-3-decIadinosyl- ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel-ervthromvcin A Example 217 4-(3-Pyridin-4-yl-l,2,4-oxadiazol-5-yl)-butyramide of (HS.21i_.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,l 1- f oxycarbonyl-(amino)-methylenel-ervthromycin A Example 218 4-(3-Pyridin-2-yl-l,2,4-oxadiazol-5-yl -butyramide of (llS.21i_,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonvI-(amino)-methylenel-ervthromvcin A Example 219 3-r3-(4-Chlorophenyl)-l,2,4-oxadiazol-5-yll-propionamide of (llS,21R,S)-3- decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel- ervthromvcin A Example 220 4-r3-(4-Chlorophenyl -l,2,4-oxadiazol-5-yll-butyramide of (llS,21-R,-_>)-3-decladinosyl- ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-roxycarbonyl-(amino)-methylenel-ervthromycin A Example 221 4-(1.3-Benzodioxol-5-yl)-butyramide of (115.21-R.S)-3-decladinosvI-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonvI-(amino -methylenel-ervthromycin A Example 222 4-r3-f5-Oxo-2.3-dihvdro-5H-ri.31thiazolo[3,2-alpyrimidin-6-yl)-l,2,4-oxadiazol-5-yll- butyramide of (1 lS.21R.S.-3-decladinosvI-l 1.12-dideoxy-6-0-methvI-3-oxo-12.11- f oxycarbonyl-(amino)-methylenel -erythromycin A Example 223 4-r3-(3-NitrophenylVl,2,4-oxadiazol-5-yll-butyramide of (HS.21i?.-_>)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 224 3-Pyrimidin-2-yl-propionamide of (HS l ,21-R.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 225 4-(2,3-Dihvdro-l,4-benzodioxin-6-vI)-butyramide of (ll-y,21R.ιS)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-famino -methvIenel-ervthromvcin A Example 226 3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yll-propionamide of (HS.21R,S)-3- decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel- ervthromycin A Example 227 4-QH-IndoI-3-vI.-butyramide of fllS.21-R.S.-3-decladinosyl-ll,12-dideoxy-6-O-methyl- 3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 228 f5-Trifluoromethyl-pyridin-2-ylsulfanyl -acetamide of (ll-_f,21-R.S)-3-decladinosyl-ll,12- dideoxy-6-Q-methyl-3-oxo-l 2,11- f oxycarbonvI-(amino -methylenel -erythromycin A Example 229 (Ouinolin-8-yloxy)-acetamide of (ll>_».21i-,-9)-3-decladiιιosyl-ll,12-dideoxy-6-O-methyl- 3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 230 3-(OuinoxaIin-2-ylsulfanyl)-propionamide of (llS.21i-.S)-3-decladinosyl-ll,12-dideoxy- 6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-erythromvcin A Example 231 (2-Pyridin-2-yl-6-trifluoromethyl-pyrimidin-4-ylsuIf anvD-acetamide of (1 lS.21_R.S)-3- decladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonvI-(amino)-methylenel- erythromycin A Example 232 3-(3-Chloro-5-trifluoromethyl-pyridin2-yl)-acryIamide of (llS,21-R,ιS r .-3-decladinosyl- ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methvIene1-ervthromvcin A Example 233 3-Pyridin-2-yl-acrylamide of (llS.21-R,S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,ll-foxycarbonyl-.amino -methvIenel-ervthromycin A Example 234 (2,2-Dimethyl-4-oxo-chroman-7-yloxy)-acetamide of (HS.21_f?.S)-3-decladinosyl-ll,12- dideoxy-6-Q-methyl-3-oxo-12,l 1- roxycarbonyl-(amino)-methylenel-ervthromvcin A Example 235 [3-(5-Oxo-2,3-dihvdro-5---?-thiazolof3,2-fllpyrimidip-6-yl)-fl,2,41oxadiazol-5- ylmethylsulf anvil -acetamide of (1 IS, 2 l_R.S)-3-decladinosyl-l 1 ,12-dideoxy-6-0-methyl-3- oxo-12,ll-foxycarbonyl-(amino -methylenel-ervthromycin A Example 236 (5,6,7,8-Tetrahvdro-quinazolin-4-ylsulfanyl)-acetamide of (llS,21i-',S)-3-decIadinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-erythromvcin A Example 237 Benzo.l,31dioxol-5-yl-propionamide of (llS.21-R,S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 238 f5-(5-Nitro-furan-2-yl)-ri,3,41oxadiazol-2-ylsulfanyll-acetamide of (llS.21R,S)-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methvIene1- erythromycin A Example 239 (Pyridin-2-ylsttlfanylVacetamide of (HS,21i?,--> r )-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylene1-erythromycin A Example 240 l(2-Phenoxy-pyridine-3-carbonyl)-aminol -acetamide of (1 IS, 2 li?.S)-3-decIadinosyl- ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-erythromvcin A Example 241 3-Benzofl,31dioxol-5-yl-2-cvano-acryIamide of (HS,21-??.S)-3-decladinosvI-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 242 ( " Benzenesulfonyl-pyridin-2-yl-amino)-acetamide of (llS,21ii-,S)-3-decladinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylene1-ervthromycin A Example 243 (3-Chloro-4-methyl-2-oxo-2H-chromen-7-yloxy -acetamide of (HS,21_g,-y)-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino ' .-methylenel- erythromycin A Example 244 (5-Bromo-4-hvdroxy-2-methyl-pyridin-3-yloxy'.-acetaiiiide of (llS.21i-',--t , )-3- decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel- ervthromvcin A Example 245 r4-Methyl-4H-11.2.41triazol-3-ylsulfanyl)-acetamide of fllS.21R.S.-3-decIadinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylene1-ervthromvcin A Example 246 (2,2,5-Trimethyl-4-oxo-chroman-7-yloxy -acetamide of (llS.21R.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 247 3-(l-tert-Butyl-3,5-dimethyl-lH-pyrazol-4-vI)-acrylamide of (llS.21-R,S)-3-decladinosyI- 11,12-dideoxy-6-O-methyl-3-oxo-l 2,11- 1 oxycarbonyl-(amino)-methylenel -erythromycin A Example 248 (lH-Indol-3-ylVacetamide of (llS.21i..Sl-3-decladinosyl-ll,12-dideoxy-6-Q-methyl-3- oxo-12,11-f oxycarbonyl-(amino)-methylenel-ervthromycin A Example 249 Thien-3-yl-acetamide of (llS,21_g,--* r )-3-decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,11- roxycarbonvHaminoVmethylenel-ervthromvcin A Example 250 (2-PhenvI-l,3-thiazol-4-yl -acetamide of (HS.21J?.-_>)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-famino -methylenel-ervthromycin A Example 251 (lH-Indol-3-yl)-oxo-acetamide of (llS,21-R,S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl- 3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromvcin A Example 252 Thien-2-yI-acetamide of (llS,21_g,S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonyl-(amino -methylenel-ervthromycin A Example 253 lH-Imidazol-4-yl-acetamide of (llS.21-R.S.-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 254 l,3-Benzodioxol-5-y-acetamide of (llS,21i?.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl- 3-oxo-l 2,11- [oxycarbonvHaminoVmethylenel -erythromycin A Example 255 (2-Pyrazin-2-yl-l,3-thiazol-4-yf)-acetamide of (llS.21R,S)-3-decladinosyl-ll,12-dideoxy- 6-0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylene1-ervthromycin A Example 256 ( 5-Bromo-lH-indol-3-yl)-acetamide of (1 lS.21-g.S)-3-decIadinosyl-l l,12-dideoxy-6-O- methyl-3-oxo-12,ll-roxycarbonyl-(amino -methylenel-ervthromycin A Example 257 l-Benzothien-3-yl-acetamide of (1 IS.2 l_R.S)-3-decladinosyl-l 1 ,12-dideoxy-6-O-methyI-3- oxo-12,1 l-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 258 Pyridin-2-yl-acetamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-[oxycarbonyl-famino)-methylenel-ervthromycin A Example 259 α-MethvKZH-indol-3-vf)-acetamide of (llS.21-g.S,-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 260 f5-Fluoro-li-7-indol-3-yl -acetamide of (llS.21-R.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Example 261 fS-Methoxy-lH-indoI-S-vD-acetamide of (llS.21ig.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methyIenel-ervthromvcin A Example 262 (4-Oxo-3,4-dihydrophthalazin-l-yI)-acetamide of (HS.21R.S)-3-decIadinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyI-(amino)-methylenel-ervthromvcin A Example 263 (5-Methyl-2.4-dioxo-3.4-dihvdropyrimidin-l(2H)-yl -acetamide of (11S.21-R.S.-3- decladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel- erythromycin A Example 264 (l,5-Dimethyl-3-oxo-2-phenyl-2,3-dihvdro-lH-pyrazol-4-yl)-acetamide of (11S.21R.S.-3- decladinosyl-ll,12-dideoxy-6-0-methvI-3-oxo-12,ll-foxycarbonyl-(amino -methvIene.- erythromycin A Example 265 (5-Methoxy-2-methyl-lH-indoI-3-vI.-acetamide of (llS.21R.S.-3-decladmosyl-11.12- dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 266 (2-Methyl-lH-indol-3-yl -acetamide of (llS.21R,S.-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 267 (5-Methyl-2-phenyl-1.3-oxazol-4-yl)-acetamide of (llS.21i?.S)-3-decladinosyl-11.12- dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-(amino -methylene1-erythromvcin A Example 268 (6-Hvdroxy-pyridazin-3-yl)-(4-methoxy-phenyl -acetamide of (11S.21R.S.-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel- erythromycin A Example 269 (5-Methyl-l-phenyl-lH-pyrazol-4-yl -acetamide of (llS.21jg.S)-3-decladinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 270 (5-Methyl-2-phenyl-l,3-thiazol-4-ylVacetamide of (llS.21 J R.S)-3-decladinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel-ervthromycin A Example 271 Pyridm-3-yl-acetamide of (llS,21i?.S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo- 12,ll-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 272 (5-Hvdroxy-l_f7-indol-3-ylVacetamide of (llS.21-g.S.-3-decladinosyl-ll,12-dideoxy-6-O- methvI-3-oxo-12.11-foxycarbonyl-(amino)-methylenel-erythromvcip A Example 273 l-Benzothien-4-yl-acetamide of (llS.21_g.S)-3-decIadinosyl-ll,12-dideoxy-6-O-methyl-3- oxo-12,11 - f oxycarbonyl-faminoVmethylenel -erythromycin A Example 274 2-Furyl-acetamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll- [oxycarbonvKaminoVmethylenel -erythromycin A Example 275 (2,3-Dimethyl-lH-indol-5-yl -acetamide of (TlS,21-g,S)-3-decladinosyl-ll,12-dideoxy-6- O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-erythromvcin A Example 276 4-(l,3-Benzothiazol-2-yl)-butyramide of (HS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-erythromvcin A Example 277 3-(2-Methyl-lH-indol-3-yl)-propionamide of iS.21_R.S)-3-decIadinosyl-ll,12-dideoxy- 6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino -methylenel-ervthromycin A Example 278 4-r3-f5-Nitrothien-3-vI)-l,2,4-oxadiazol-5-yIl-butyramide of (HS.21R.S)-3-decladinosyl- ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonvI-(amino)-methvIeneI-ervthromvcin A Example 279 3-(l-Methyl-lH-benzimidazol-2-yl)-propionamide of (llS.21i_,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 280 3-(4,6-Dimethoxypyrimidin-2-yl)-propionamide of (llS,21-g,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 281 (6,7-Dmethoxy-isoqι-inolin-4-yI)-acetamide of (llS,21R,S)-3-decladinosyl-ll,12-dideoxy- 6-O-methyl-3-oxo-12,ll-foxycarbonv--(amipo)-methylene1-erythromvcin A Example 282 f3-(2-Chlorophenyl)-5-methyl-isoxazol-4-yll-acetamide of (llS.21i_.ι->)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromycin A Example 283 f4-(4-Oxo-l,2,3-benzotriazin-3(41_r)-yl)phenvn-acetamide of (llS.21-R.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino -methylenel-ervthromycin A Example 284 ,2-.2.4-DifluoroDhenyl -l,3-thiazol-4-yll-acetamide of (llS.21-R.S.-3-decladinosyl-ll,12- dideoxy-6-0-methvI-3-oxo-12,ll-foxycarbonyl-(amino)-methvIenel-ervthromvcin A Example 285 12-(jf(5-Methyl-l,3,4-thiadiazol-2-yl)thio1acetv amino)-l,3-thiazol-4-vn-acetamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl- (amino)-methylenel -erythromycin A Example 286 (2-{r( yridin-2-ylthio^acetyllaminoVl,3-thiazoI-4-vn-acetamide of (llS,21ig.S)-3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylene1- ervthromvcin A Example 287 (2-(KPhenylthio^acetyllaminoI-l,3-thiazol-4-yl -acetamide of (llS,2LR.S)-3- decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel- erythromycin A Example 288 {2-f(4-Bromobenzoyl aminol-l,3-thiazol-4-v acetamide of (HS,21jg,S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino -methylenel-ervthromycin A Example 289 (2-K3-Chlorobenzoyl aminol-l,3-thiazol-4-yll-acetamide of (llS.2lJ-,S -3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromycin A Example 290 (2-[(2-Chlorobenzoyl aminol-l,3-thiazol-4-vU-acetamide of (HS,21-?.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methvIenel-ervthromvcin A Example 291 ri-(6-Chloropyridazin-3-yl -lH-indol-3-yl1-acetamide of (HS.21R.S)-3-decladinosyl- ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylene1-erythromvcin A Example 292 .2-f4-ChIorophenyl)-1.3-thiazol-4-vn-acetamide of (llS,21-R,S)-3-decladinosyl-11.12- dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromvcm A Example 293 [4-(4-Bromophenyl)-5-oxo-4.5-dihvdro-lH-1.2,4-triazol-l-vn-acetamide of (11S.21-R.S)- 3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-toxycarbonyl-(ammoV methylenel-erythromycin A Example 294 (2-Oxo-l,3-benzoxazol-3(2H)-yl -acetamide of iS.21i_.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylene1-erythromvcin A Example 295 .2-(4-Methoxyphenyl)-1.3-thiazol-4-yl1-acetamide of (llS,21Jg.S)-3-decIadinosvI-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(amino)-methyIenel-ervthromycin A Example 296 3-Furyl-acetamide of (llS.21i-',S)-3-decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12,ll- toxycarbonvHaminoVmethylenel-ervthromvcin A Example 297 f4-MethvI-2-thioxo-1.3-thiazol-3(2H)-yl)-acetamide of (llS.21R,S)-3-decladinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromycin A Example 298 12-(BenzoylaminoVl,3-thiazol-4-yll-acetamide of (llS.21-g,S.-3-decladinosyl-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylene1-ervthromycin A Example 299 r4-(3,5-Dimethyl-lH-pyrazoI-l-yl)phenyll-acetamide of (llS,21i?.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonvI-(amino)-methylenel-erythromvcin A Example 300 r4-(lH-Pyrazol-l-yl)phenyll-acetamide of (llS.21-R.S.-3-decladinosyl-11.12-dideoxy-6- 0-methvI-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromvcin A Example 301 l-Benzofnran-4-yl-acetamide of (llS,21-R,S)-3-decIadinosyl-ll,12-dideoxy-6-0-methyl- 3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromycin A Example 302 2-Acetylamino-3-(l_g-indol-3-yl)-propionamide of (llS.21-R.S)-3-decladinosyl-ll,12- dideoxy-6-0-methvI-3-oxo-12,ll-roxycarbonyl-ramino)-methylenel-ervthromycin A Example 303 3-(l,3-Benzodioxol-5-yl)-propionamide of (llS.21-R.S)-3-decIadinosvI-ll,12-dideoxy-6- 0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromycin A Example 304 3-(lfl-Benzimidazol-2-yl)-propionamide of (llS,21-R.S)-3-decIadinosyl-ll,12-dideoxy-6- 0-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methyIenel-ervthromycin A Example 305 3-(6-Ethylsulfanyl-pyridin-3-yl)-acrylamide of (HS.21ϋ?.S)-3-decladinosyl-l 1.12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromycin A Example 306 I4-Oxo-2-(lH-tetrazol-5-ylV4H-chromen-7-yloxy1-acetamide of (11S.21-R.S.-3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-loxycarbonyl-(amino)-methylenel- erythromycin A Example 307 3-(l-Oxoisoqninolin-2flH)-yl)-propionamide of fllS.21i-.S)-3-decladinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(amino)-methylenel-ervthromycin A Example 308 2-Benzoylamino-3-(l_ff-imidazol-4-yl)-propionamide of (1 lS,21- ,iy)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 309 3-Thien-2-yl-propionamide of (llS.21-R,S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,1 l-[oxycarbonyl-(amino)-methylenel-ervthromycin A Example 310 (3-Methyl-6-trifluoromethyl-3---- r -imidazor4,5-blpyridin-2-ylsulfanyl)-acetamide of (llS.21-R.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl- (amino)-methylenel-ervthromycin A Example 311 [(2-p-Tolvsulfanyl-pyridine-3-carbonyl -aminol-acetamide of (HS,21-R,S)-3- decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel- erythromycin A Example 312 3-[3-(3-nitrophenyl)-l,2,4-oxadiazol-5-yll-propionamide of (llS.21-g.-->)-3-decladinosyl- ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylene1-erythromycin A Examples 148-312 were obtained starting from example 6 (5 mg) by following the same procedure as reported for Example 147. The name and amount of starting material (i.e carboxylic acid) and LC MS analysis (retention time and m/z) of examples 148-312 are reported in the Table 1. Example 313 (2i?)-2-A--tιino-3-(lH r -indol-3-vn-propionamide of (llS,2LR.S.-3-decladinosyI-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A To (2R)-tert-butoxycarbonylamino-3-(lH-indol-3-yl)-propionic acid (0.0025g) a solution of ΗATU (0.003g) in anhydrous DMF (0.050mL) and DIPEA (0.002mL) in anhydrous DMF (0.050mL) were added, followed by a solution of example 6 (0.005g) in anhydrous DMF (0.050mL). The reaction mixture was stirred at room temperature for 18h, then it was diluted with DCM (0.350mL), washed with a 5% NaΗC0 3 aqueous solution (0.300mL), then passed through a phase-separation syringe. The aqueous phase was exfracted with DCM (0.250mL) and the collected organic extracts evaporated under vacuum. The residue was dissolved in a 10% TFA solution in anhydrous DCM (0.300mL) and the mixture stirred for 1.5h. The solution was diluted with EtOAc (0.400mL) then solvents evaporated under reduced pressure. The crude material was dissolved in DCM (OJOOmL), loaded on SCX-cartridge (lOOmg, loading 0.75mmol/g, previously washed with 4mL of MeOH), washed with MeOH (4mL), then the product eluted with NH 3 (0.25M solution in MeOH, 1.5mL), followed by MeOH (2mL) and solvents evaporating under vacuum. The residue was dissolved in MeOH (1.7mL) and stirred overnight at room temperature. After evaporating the solvent the title compound (O.OOlg) was obtained. LC/MS analysis (mobile phase: A/B from 90/10 to 10/90 in 10 min, 10/90 for 3 min; mass range 150-1000 amu): retention time: 4.95 min, mVz ([MH] + ) = 813. Examples 314-320: Example 314 (2S.-2-Amino-3-(l-methyl-lH-imidazoI-5-ylVpropionamide of fllS.21jg.S.-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino -methylenel- erythromycin A Example 315 (2-R)-2-Amino-3-(l,3-thiazol-4-yl)-propionamide of (HS.21R.S)-3-decIadinosvI-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcip A Example 316 (2S)-2-Amino-3-(l,3-thiazoI-4-yl -propionamide of (HS.21i?.S)-3-decIadinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromvcin A Example 317 (2i-)-2-Amino-3-(lH-imidazol-5-yl)-propionamide of (llS.21-R.S.-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,l 1- [oxycarbonyl-(amino)-methylenel-erythromvcin A Example 318 (2-R)-2-Amino-3-pyridin-3-vI-propionamide of (llS,21i_,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel-ervthromycin A Example 319 decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino -methylenel- ervthromvcin A Example 320 (2S)-2-Amino-3-pyridin-2-vI-propionamide of (1 lS.21-R.S)-3-decladinosyl-l 1,12-dideoxy- 6-O-methyl-3-oxo-12,ll-foxycarbonyI-(amino)-methylenel-ervthromvcin A Examples 314-320 were obtained starting from example 6 (5 mg) by following the same procedure as reported for Example 313. The name and amount of starting material (i.e carboxylic acid) and LC/MS analysis (retention time and m z) of examples 314-320 are reported in the table 2. Table 2 Example 321 (2S)-2-Amino-3-pyridin-4-yl-propionamide of (HS.21-R.--i r )-3-decladinosvI-ll,12-dideoxy- 6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino -methylenel-erythromvcin A To (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-pyridin-4-yl-propionic acid (0.0032g) a solution of ΗATU (0.003g) in anhydrous DMF (0.050mL) and DIPEA (0.002mL) in anhydrous DMF (0.050mL) were added, followed by a solution of example 6 (0.005g) in anhydrous DMF (0.050mL). The reaction mixture was stirred at room temperature for 18h, then it was diluted with DCM (0.350mL), washed with a 5% NaΗC0 3 aqueous solution (0.300mL), then passed through a phase-separation syringe. The aqueous phase was exfracted with DCM (0.250mL) and the collected organic extracts evaporated under vacuum. The residue was dissolved in anhydrous DMF (0.350mL) then piperazinomethyl polystyrene resin (0.030g, loading 1.39 mmol/g) was added and the mixture stirred for 2.5 days. The mixture was filtered and the resin rinsed with DCM (0.400mL), DMF (0.400mL) and DCM (0.200mL) and the filtrates evaporated under reduced pressure . The crude material was dissolved in DCM (OJOOmL), loaded on SCX-cartridge (lOOmg, loading 0.75mmol/g, previously washed with 4mL of MeOH), washed with MeOH (4mL), then the product eluted with NH 3 (0.25M solution in MeOH, 1.5mL), followed by MeOH (2mL) and solvents evaporating under vacuum. The residue was dissolved in MeOH (1.7mL) and stirred overnight at room temperature. After evaporating the solvent the title compound (O.OOlg) was obtained. LC/MS analysis (mobile phase: A/B from 90/10 to 10/90 in 10 min, 10/90 for 3 min; mass range 150-1000 amu): retention time: 3.98/4.70 min, mVz ([MH] + )= 775. Examples 322-327: Example 322 (2S)-2-Amino-3-{l-r(benzyloxy)methyll-lH-imidazol-5-yl>-propionamide of (11S.21R.S)- 3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)- methylenel -erythromycin A Example 323 (2-^-2-Amino-3-(l-benzyl-lH-imidazol-4-yl)-propionamide of (11S.2LR.S.-3- decIadinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel- erythromycin A Example 324 (2S)-2-Amino-3-(lH-imidazol-4-yl)-propionamide of (llS,21-R,S)-3-decIadinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 325 (2--^-2-Amino-3-Il-r(ben-wloxy)methyll-lH-i dazol-4-yl)-propiona---ude of fllS,21-R,S)- 3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)- methylenel -erythromycin A Example 326 (3S,-3-Amino-4-(lH-indol-3-yl)-butyramide of (llS.2LR.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(amino)-methylenel-ervthromvcin A Example 327 (2_R)-2-Amino-3-pyridin-4-yl-propionamide of (llS,21-R,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(amino)-methylenel-ervthromvcin A Examples 322-327 were obtained starting from example 6 (5 mg) by following the same procedure as reported for Example 321. The name and amount of starting material (i.e carboxylic acid) and LC/MS analysis (retention time and m/z) of examples 322-327 are reported in the table 3. Table 3 Example 328 (llS,21i?,S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl- (benzoyl-ur eido - methylenel -erythromycin A To a solution of example 6 (0.005g) in anhydrous TΗF (O.lOOmL) a solution of benzoyl isocyanate (2.2mg) in anhydrous TΗF (0.300mL) was added. The reaction mixture was heated at 60°C for 24h. After cooling to room temperature PS-Trisamine resin (loading 3.62mmol/g, 0.030g) was added and reacted at 60°C for 24h. After cooling to room temperature the mixture was filtered and the resin rinsed with TΗF (2x0.240mL), DCM (2x0.240mL), TΗF (4x0.170mL) and the filtrate evaporated. The residue was dissolved in MeOΗ (ImL) and reacted at room temperature overnight. After evaporating the solvent the title compound (0.003g) was obtained. LC/MS analysis (mobile phase: A/B from 90/10 to 10/90 in 10 min, 10/90 for 2 min; retention time: 6.08/6.5 lmin, mVz ([MΗ] + ) = 774. Examples 329-398: Example 329 (llS,21--?.S)-3-Decladinosyl-ll,12-dideoxy-6-Q-methyl-3-oxo-12,ll-foxycarbonyl- (phenyl-ureido)-methylenel -erythromycin A Example 330 (llS.21ϋ;.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(f2.6- dichloropyridin-4-ylVur eido)-methylenel -erythromycin A Example 331 (HS.21R.-_>)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(f3.5- dimethylisoxazol-4-yl)-ur eidoVmethylenel -erythromycin A Example 332 fllS.21-R.Sl-3-Decladinosyl-ll,12-dideoxy-6-Q-methyl-3-oxo-12,ll-roxycarbonyl- (( pyridin-3-vD-ur eidoVmethylenel -erythromycin A Example 333 (llS.21i?.S)-3-DecladinosvI-ll,12-dideoxy-6-0-methvI-3-oxo-12,ll-roxycarbonyl- ((2,2,4,4-tetr afluoro-4H-l ,3-benzodioxin-6-yl)-ureido)-methylene1 -erythromycin A Example 334 (llS.21i?.Sl-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl-f(4- (N,N-dimethylamino phenyl)-ureido)-methylenel -erythromycin A Example 335 (llS.21R.S.-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-((4- nitrophenvD-ureidoVmethylenel -erythromycin A Example 336 (llS.21R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-((3- nitrophenvD-ur eidoVmethylenel -erythromycin A Example 337 (llS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-((2- nitrophenyl)-ureido)-methylenel -erythromycin A Example 338 (llS.21i?.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonvI-f(3,5- dinitrophenylV ur eido)-methylenel -erythromycin A Example 339 fllS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12.11-foxycarbonyl-((4- methyl-2-nitrophenyl -ur eido -methylene1 -erythromycin A Example 340 (llS.21-g.S.-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-rιr2- methyl-4-nitrophenyl -ureido)-methvIenel-ervthromvcin A Example 341 (llS.21R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-(f2- methyl-5-nitrophenyl 1 -ur eido)-methylenel -erythromycin A Example 342 fllS.21-R.S.-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-foxycarbonvI-f(4- methyl-3-nitr ophenyl)-ureido)-methyIenel -erythromycin A Example 343 (llS.21-g.S)-3-DecIadinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-(t2- methyI-3-nitrophenyl)-ureido)-methylenel -erythromycin A Example 344 (llS.21-R.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-[oxycarbonyl-((2- methyI-6-nitrophenvI)-ureido)-methylenel-ervthromvcin A Example 345 rilS.21i?.Sl-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12.11-[oxycarbonyl-((5- chloro-2-nitrophenyl)-ureido)-methylene1-ervthromvcin A Example 346 (llS.21i_.S)-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonvI-f(2- chloro-4-nitrophenyl)-ureido)-methylenel -erythromycin A Example 347 (llS.21_R.--t)-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-fιr4- chloro-3-nitrophenvD-ur eido)-methylenel -erythromycin A Example 348 (llS,2lJ?.S)-3-DecIadinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-t(4- chloro-2-nitr ophenylVureidoVmethylenel -erythromycin A Example 349 ( 1 lS.21-R.S)-3-Decladinosyl-l l,12-dideoxy-6-Q-methyl-3-oxo-12.11- [oxycarbonyl-((4- fluoro-3-nitrophenylVur eidoVmethylenel -erythromycin A Example 350 (HS,21i?,S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-((2- fluoro-5-nitrophenylVureidoVmethyIenel -erythromycin A Example 351 (llS.21-R.S)-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonvI-f(2- methoxy-5-nitrophenyIVur eido -methylenel -erythromycin A Example 352 (llS.21-R.S)-3-DecladinosvI-11.12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-((2- methoxy-4-nitrophenyl)-ur eidoVmethylenel -erythromycin A Example 353 (ll-_-'.21-g.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonvI-(f4- methoxy-2-nitrophenylVur eido)-methylenel -erythromycin A Example 354 (llS,21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-Q-methyl-3-oxo-12,ll-roxycarbonyl-((4- methoxyphenvIVureidoVmethylenel-ervthromvcin A Example 355 fllS.21R.S -3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-(t3- methoxyphenylVureidoVmethylenel-erythromvcin A Example 356 (llS.21-g.S)-3-Decladinosyl-ll,12-dideoxy-6-Q-methvI-3-oxo-12,ll-roxycarbonyl-((2- methoxyphenyl)-ureido -methylenel -erythromycin A Example 357 (llS,21-R.S)-3-DecIadinosvI-ll,12-dideoxy-6-Q-methvI-3-oxo-12,ll-roxycarbonvI-((3,4- dimethoxyphenylVur eidoVmethylenel -erythromycin A Example 358 (llS.21-R.S.-3-Decladinosyl-ll,12-dideoχy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-((2,4- dimethoxyphenyl)-ureido -methylenel -erythromycin A Example 359 (llS.21_g.S.-3-DecladinosvI-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-((2,5- dimethoxyphenylVur eido -methylene1 -erythromycin A Example 360 (llS.21-R.S.-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-loxycarbonyl-((3,5- dimethoxyphenyl)-ur eidoVmethylenel -erythromycin A Example 361 fllS.21-g.S.-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-ff2.6- dimethoxyphenylVureidoVmethylenel -erythromycin A Example 362 ( 1 lS.2H-.SV3-Decladinosyl-l 1.12-dideoxy-6-O-methyl-3-oxo-12,l 1- f oxycarbonyl-f (1.3- benzodioxol-5-yl)-ureido)-methylene1 -erythromycin A Example 363 αi--f.21R.--D-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-foxycarbonyϊ-r(2- methoxy-5-methylphenylVureidoVmethylenel -erythromycin A Example 364 (llS.21R,S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-f(2- ethoxyphenylVur eidoVmethylenel -erythromycin A Example 365 (llS,21R.S)-3-DecladinosvI-ll,12-dideoχy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-f(4- ethoxyphenylVur eidoVmethylenel -erythromycin A Example 366 (llS.21_g.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-f(4- phenoxyphenviVureidoVmethylenel -erythromycin A Example 367 (llS.21-g.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyI-3-oxo-12.11-loxycarbonyl-f(2- phenoxyphenyl)-ureido)-methylene]-erythromycin A Example 368 rilS.21R.--D-3-DecladinosvI-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-fr3- phenoxyphenyl)-ureido -methylenel -erythromycin A Example 369 fllS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-(r3- (cvclopentyloxyV4-methoxyphenylVureidoVmethylenel-ervthromvcin A Example 370 (llS.21-R.S)-3-DecIadinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-r(5- chIoro-2-methoxyphenylVureido Vmethylenel -erythromycin A Example 371 fllS.21R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-f(3- chlor o-4-methoxyphenyl)-ureido)-methylenel -erythromycin A Example 372 (HS.21i?.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-ff5- chloro-2,4-dimethoxyphenyl)-ureido)-methylene1-erythromvcin A Example 373 iS t 21J?,S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-r(4- (trifluor omethoxy.phenylVureidoVmethyIene1 -erythromycin A Example 374 tllS.21-g.S)-3-DecIadinosvI-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-rr2- (trifluoromethoxy)phenylVureidoVmethylenel-ervthromycin A Example 375 αiS.21R,S)-3-Decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12.11-foχycarbonvI-f(4- (difluoromethoxy.phenylVureidoVmethylenel -erythromycin A Example 376 (llS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methvI-3-oxo-12.11-[oxycarbonyl-((2- (difluoromethoxy)phenvIVureidoVmethylenel -erythromycin A Example 377 (llS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-f(4- (methylthio)phenyl)-ur eido -methylenel -erythromycin A Example 378 (llS.21i?.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-(f3- (methylthio)phenylVur eidoVmethylenel -erythromycin A Example 379 (llS.21i?.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-l2.11-roxycarbonyl-(f2- (methvIthio)phenylVureidoVmethylene] -erythromycin A Example 380 αiS.21i-.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-[oxycarbonyl-(f4- 1 (trifluoromethyDthiol phenyl)-ureido -methylenel -erythromycin A Example 381 (llS.21i?,S)-3-Decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12.11-roxycarbonyl-f(4- acetvIphenylVureidoVmethylenel-ervthromvcin A Example 382 (llS,21-R,S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-f(3- acetyIphenyl)-ureido)-methylenel-ervthromycin A Example 383 (HS.21i?.Sl-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-[oxycarbonyl-((4- cyanophenvD-nr eido)-methylenel -erythromycin A Example 384 fllS.21-R.S.-3-Decladinosyl-11.12-dideoxy-6-Q-methyl-3-oxo-12,ll-roxycarbonvI-tt3- cyanophenylVureidoVmethylenel -erythromycin A Example 385 fllS,21R.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonvI-f(3- (trifluoromethyl -phenyl)-ur eidoVmethylenel -erythromycin A Example 386 fllS.21_g.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-((4- chlor ophenylVureido Vmethylenel -erythromycin A Example 387 fllS.21-R.S.-3-DecIadinosyl-11.12-dideoxy-6-O-methvI-3-oxo-12.11-foxycarbonyl-r(3- chlorophenvI)-ur eido)-methylenel -erythromycin A Example 388 (llS.21_g.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl-((2- chlorophenyl)-ureido)-methvIenel -erythromycin A Example 389 fllS.21-R.S)-3-Decladinosyl-11.12-dideoxy-6-O-methvI-3-oxo-12,ll-roxycarbonyl-((3.4- dichlorophenvD-ureido Vmethylenel -erythromycin A Example 390 fllS.21-g.Sl-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(t4- fluorophenyl)-ureido)-methylenel-erythromvcin A Example 391 (llS.21_R.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl- ("(benzyl)-ureido)-methylenel-ervthromvcin A Example 392 fllS.21-R.S.-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(f4- methoxybenzylVureidoVmethylenel-erythromvcin A Example 393 (llS.21-g.S)-3-DecladinosvI-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-ff2- chlorobenzyl -ureido)-methylenel-ervthromvcin A Example 394 (llS,21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-ιrf3.4- dichlorobenzyl)-ureido)-methylenel-ervthromvcin A Example 395 (llS.21-R.S.-3-Decladinosyl-ll,12-dideoxy-6-Q-methyl-3-oxo-12,ll-roxycarbonyl-((4- fluorobenzvIVureidoVmethylenel-ervthromycin A Example 396 tll_-* r .21i?.S.-3-DecladinosvI-11.12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-((4- bromobenzyl)-ureido)-methvIenel-erythromvcin A Example 397 (llS.21R.Sl-3-Decladinosyl-11.12-dideoxy-6-Q-methvI-3-oxo-12,ll-roxycarbonyl-((2- phenylethvD-ureido Vmethylenel -erythromycin A Example 398 fllS.21_f?.S.-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-((2- thien-2-ylethyl)-ureido -methylenel -erythromycin A Examples 329-398 were obtained starting from example 6 (5 mg) by following the same procedure as reported for Example 328. The name and amount of starting material (i.e isocyanate) and LC/MS analysis (retention time and m z) of examples 329-398 are reported in the table 4. Table 4 Example 399 (llS,21J?,-_>)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl- (benzoyl-thioureidoVmethylenel-erythromvcin A A solution of example 6 (0.005g) in MeOH (0.350mL) was reacted overnight at room temperature. After evaporating the solvent a solution of benzoyl isothiocyanate (2.4mg) in DCE (0.400mL) was added and the reaction mixture was heated at 60°C for 26h. After cooling to room temperature PS-Trisamine resin (loading 3.62mmol/g, 0.030g) was added and reacted at room temperature for 15h. The mixture was filtered and the resin rinsed with DCE (2x0.230mL), DCM (3x0.160mL, 2x0.120mL). The filtrate was evaporated to give the title compound (0.003g). LC/MS analysis (mobile phase: A/B from 90/10 to 10/90 in 16 min, 10/90 for 4 min; retention time: 9.1/lO.Omin, mVz ([MH] + ) = 790. Examples 400-425: Example 400 fllS.21-R.-->)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-[oxycarbonyl-ff4- (N.N-dimethylaminoVphenylVthioureidoVmethylene1 -erythromycin A Example 401 iS.21R.S)-3-Decladinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12.11-foxycarbonyl-ff4- fN.N-diethvIamino phenylVthioureidoVmethylenel-ervthromycin A Example 402 rilS.21_??.S)-3-Decladinosyl-11.12-dideoxy-6-0-methyl-3-oxo-12.11-Foxycarbonyl-(tr4- (iV,N-dimethylamino -l-naphthyl)-thioureido)-methylenel-ervthromvcin A Example 403 iS,21R,S)-3-DecIadinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-r 4- nitrophenylVthiour eidoVmethylenel -erythromycin A Example 404 rilS.21i?.S.-3-DecladinosvI-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-foxycarbonyl-r(2- methyl-5-nitrophenylVthioureidoVmethylenel-ervthromycin A Example 405 rilS.21,R.S.-3-DecladinosvI-ll,12-dideoxy-6-O-methvI-3-oxo-12.11-roxycarbonvI-tf2- chloro-4-nitrophenylVthiour eidoVmethylenel -erythromycin A Example 406 (llS,21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methvI-3-oxo-12.11-foxycarbonyl-((2- methoxy-4-nitrophenylVthiour eido)-methylenel -erythromycin A Example 407 αiS.21-R.S)-3-DecIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-foxycarbonyl-fr4- methoxy-2-nitrophenylVthioureido Vmethylenel -erythromycin A Example 408 iS.21J?.S)-3-DecIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-ff2- methoxyphenyl)-thioureido)-methylenel -erythromycin A Example 409 fllS.21R.S)-3-DecladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-ff2.5- dimethoxyphenylVthiour eidoVmethylenel -erythromycin A Example 410 (llS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-rf2- methoxy-5-methylphenylVthiour eido)-methylenel -erythromycin A Example 411 (llS.21-g.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-fr4- methoxy-l,l'-biphenyl-3-yl -thioureido)-methylenel-ervthromvcin A Example 412 (llS.21ig,S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-((4- ethoxyphenylVthioureido Vmethylenel -erythromycin A Example 413 (llS.21-g.S.-3-DecladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonvI-f(4- (benzyloxy phenyl)-thioureido)-methylenel-ervthromycin A Example 414 rilS.21^.Sl-3-Decladinosyl-ll,12-dideoxy-6-Q-methyl-3-oxo-12.11-foxycarbonyl-f(5- chloro-2-methoxyphenylVthiour eidoVmethylenel -erythromycin A Example 415 (llS,21_g.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-(f4- (methyIthio)-phenyl')-thioureido)-methylenel-ervthromvcin A Example 416 fllS.21R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl- ((benzyl)-thioureido)-methyIeneI-ervthromvcin A Example 417 (llS.21R.S.-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-((2- furylmethylVthiour eido -methylenel -erythromycin A Example 418 fllS.21R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl-f(4- methoxybenzylVthioureidoVmethylenel-erythromvcin A Example 419 (llS.21R.S)-3-Decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-((2- methoxybenzylVthioureidoVmethylenel-ervthromvcin A Example 420 fllS.21-R.Sl-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonvI-f(2- chlorobenzvI)-thioureido)-methylene1-ervthromvcin A Example 421 (llS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-f(3,4- dichlorobenzyl)-thioureido -methylenel-erythromvcin A Example 422 (llS.21i- l .--t)-3-DecladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-rf2- phenylethylVthiour eidoVmethylenel -erythromycin A Example 423 (llS.21J?.S.-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-((2- morphoIin-4-ylethyl)-thioureido)-methylenel-ervthromvcin A Example 424 (llS.21-R.S)-3-Decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12.11-roxycarbonyl-((2- (3,4-dimethoxyphenyl)ethylVthioureidoVmethylenel-ervthromycin A Example 425 (llS.21-R.Sl-3-DecladiPosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12.11-roxycarbonyl-((2-(4- chlorophenyl)-ethyl)-thioureido -methylene1 -erythromycin A Examples 400-425 were obtained starting from example 6 (5 mg) by following the same procedure as reported for Example 399. The name and amount of starting material (i.e isocyanate) and LC/MS analysis (retention time) of examples 400-425 are reported in the table 5. Table 5 Example 426 3-Amino-isonicotinamide of (llS.21-g.S.-3-decladinosyl-ll,12-dideoxy-6-0-methyI-3- oxo-12,ll-[oxycarbonyl-(2-(aminoVethylaminoVmethylenel-ervthromycin A To 3-amino-isonicotinic acid (O.OOlg) a solution of benzotriazole-1-yl-oxy-fris-pyrrolidino- phosphonium hexafluorophosphate (0.004g) in anhydrous DMF (0.150mL) and a solution of DIPEA (0.003mL) in anhydrous DMF (0.150mL) were added followed by the addition of a solution of example 13 (0.005g) in anhydrous DMF (O.lOOmL). The reaction mixture was stirred at room temperature for 48h, then it was diluted with DCM (0.600mL), washed with a 5% NaHC0 3 aqueous solution (0.500mL), then passed through a phase-separation syringe. The aqueous phase was exfracted with DCM (0.400mL) and the collected organic extracts evaporated under vacuum. The crude material was dissolved in DCM (0.500mL), loaded on a SCX-cartridge (250mg, loading 0.75mmol/g), washed with MeOH (4mL), then the product eluted with NH 3 (0.25M solution in MeOH, 1.5mL). After evaporating the solvent the title compound (0.003g) was obtained. LC/MS analysis (mobile phase: A/B from 90/10 to 10/90 in 10 min, 10/90 for 2 min, mass range 150-1300 amu): retention time: 4.99 min, mVz ([MH] + ) = 790. Examples 427-601: Example 427 5-Methyl-3-phenyl-isoxazoIe-4-carboxamide of (llS.21-ff.SV3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel- erythromycin A Example 428 l,5-Dimethyl-3-oxo-2-phenyl-2,3-dihvdro-lH-pyrazole-4-carboxamide of (11S.21-R.SV3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)- ethylamino Vmethylenel -erythromycin A Example 429 2-Trifluoromethyl- f 1 ,81 naphthyridine-3-carboxamide of (11S.2 lR.SV3-deeladinosvI- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-.oxycarbonyl-(2-(aminoVethylaminoV methylenel -erythromycin A Example 430 6-Nitro-2-oxo-2H-chromene-3-carboxamide of (HS,21-R,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel- erythromycin A Example 431 4-Amino-2-methylsulfanyI-pyrimidine-5-carboxamide of (HS.21.R,-->V3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino -ethylamino)- methylenel -erythromycin A Example 432 5-Chloro-l-methyl-lH-pyrazole-4-carboxamide of (llS,21-R,-SV3-decladinosyl-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino -methylenel- erythromycin A Example 433 2-Pyrazin-2-yl-thiazole-4-carboxamide of (llS.21R.SV3-decladinosvI-ll,12-dideoxy-6- 0-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 434 3-MethvI-2-oxo-l,2-dihvdro-quinoIine-4-carboxamide of (HS.21i?.SV3-decladinosvI- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino - methylenel -erythromycin A Example 435 2-Methyl-imidazofl,2,-fllpyridine-3-carboxamide of (llS,21-R,--*)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino)-methylenel- ervthromycin A Example 436 4-Methoxy-l,3-dimethyl-l J --- r -pyrazolof3,4-61pyridine-5-carboxamide of (llS,21-R,-_>)-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)- ethylamino)-methyIenel -erythromycin A Example 437 3-Methyl-5-f4-methyl-ri,2,31thiadiazol-5-yl)-isoxazole-4-carboxamide of qiS.2LR.SV3- decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyI-(2-(amino)- ethylaminol-methylenel-ervthromvcin A Example 438 4-Acetyl-l-methyl-lH-pyrrole-2-carboxamide of (HS.21-R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methvI-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel- erythromycin A Example 439 6-.l,2,41Triazol-l-vI-nicotinamide of fllS.21.R.S)-3-decladinosvI-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethvIamino -methylenel-ervthromycin A Example 440 Isonicotinamide of (llS.21R.S)-3-decIadinosyl-ll,12-dideoxy-6-O-methyI-3-oxo-12,ll- f oxycarbonyl-(2-(amino)-ethylamino -methylenel -erythromycin A Example 441 5-Oxo-2,3-dihvdro-5H-thiazoIof3,2-alpyrimidine-6-carboxamide of (HS.21R.S)-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)- ethylamino Vmethylenel -erythromycin A Example 442 5-Nitro-lH-pyrazole-3-carboxamide of (llS.21R.--*V3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 443 2-Methylsulfanyl-nicotinamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-0-methvI- 3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino -methylenel-ervthromvcin A Example 444 7-Hydroxy-2-oxo-2H r -chromene-3-carboxamide of (HS.21_R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino)-methvIenel- erythromycin A Example 445 Cinnoline-4-carboxamide of (1 lS.21-R,SV3-decladinosyl-l l,12-dideoxy-6-Q-methvI-3- oxo-12,ll-foxycarbonyl-f2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 446 6-Amino-nicotinamide of (llS,21_g.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-[oxycarbonyl-(2-(amino)-ethvIamino -methylene1-ervthromvcin A Example 447 l-Methyl-5-nitro-lH-pyrazole-4-carboxamide of (llS,21-R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(aminoVethylaminoVmethylenel- erythromycin A Example 448 4,7-Dimethyl-pyrazolo(5,l-cI fl,2,41triazine-3-carboxamide of (HS.21R.S)-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)- ethylamino)-methylenel-ervthromycin A Example 449 2-Methoxy-nicotinamide of (llS.21-R.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 450 3,5-Dimethyl-isoxazole-4-carboxamide of (llS.21R,S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino)-methylenel-ervthromycin A Example 451 4-Oxo-4,5,6,7-tetrahydro-benzofuran-3-carboxamide of (HS,21ig.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethvIamino)- methylenel -erythromycin A Example 452 3-Amino-pyrazine-2-carboxamide of (llS.21R.SV3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,l 1- f oxycarbonyl-(2-(amino)-ethylamino)-methvIeneI-ervthromvcin A Example 453 Pyrazine-2-carboxamide of (llS,21_RSV3-decIadinosvI-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 454 4-Phenyl-fl,2,31thiadiazole-5-carboxamide of (llS.21i?.S)-3-decladinosvI-ll,12-dideoxy- 6-O-methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 455 5-Methyl-3-methylsulfanyl-isothiazole-4-carboxamide of (llS.21_f_.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-.oxycarbonyl-(2-(aminoVethylaminoV methylenel -erythromycin A Example 456 2,6-Dimethyl-4-oxo-4H-pyran-3-carboxamide of (1 lS.2LR.SV3-decladinosyl-l 1,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino ' )-methylenel- erythromycin A Example 457 l-Oxo-l,2-dihvdro-isoquinoline-4-carboxamide of (HS.21R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel- erythromycin A Example 458 4-Acetyl-3-cvano-5-methyl-lH-pyrrole-2-carboxamide of (llS.21-ff.SV3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino)- methylenel -erythromycin A Example 459 4-Methyl-3-oxo-3,4-dihydro-2H-benzo ri,41thiazine-6-carboxan_Ade of (HS.21J-!.S)-3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)- ethylamino -methylenel -erythromycin A Example 460 6-MethvI-imidazo[2,l-61thiazole-5-carboxamide of (HS.21-g.S)-3-decladinosyI-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino -ethylamino)-methylene1- ervthromvcin A Example 461 2-Phenoxy-nicotinamide of (llS.21-ff.SV3-decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 462 5-Nitro-lH-indole-2-carboxamide of (llS.21i-.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylene1-ervthromycin A Example 463 4,8-Dihvdroxy-quinoline-2-carboxamide of (HS.2ϋ_.S)-3-decladinosyl-ll,12-dideoxy-6- Q-methyl-3-oxo-12,l 1- [oxycarbonyl-(2-(aminoVethylamino Vmethylenel -erythromycin A Example 464 2-Hvdroxy-quinoline-4-carboxamide of (HS.21i-'.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethylamino)-methyleneI-ervthromvcin A Example 465 qH-Indol-3-ylVoxo-acetamide of (llS.212?,SV3-decladinosyl-ll,12-dideoxy-6-O-methyl- 3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 466 Furan-2-yl-oxo-acetamide of (1 lS,21_g.SV3-decladinosyl-l l,12-dideoxy-6-0-methyI-3- oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylene1-ervthromycin A Example 467 2-Amino-nicotinamide of (llS.21ϋ-.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-[oxycarbonyl-(2-(amino -ethylamino)-methylenel-ervthromycin A Example 468 lH-Benzotriazole-S-carboxamide of (llS.21i-'.S)-3-decIadinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino)-methylenel-ervthromycin A Example 469 3-Methyl-furan-2-carboxamide of (llS.21R.S)-3-decladinosyI-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino)-methylenel-ervthromvcin A Example 470 5-Chloro-l,3-dimethyl-lH-pyrazole-4-earboxamide of (llS.21-R.S)-3-decladmosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino ' )-ethylamino)-methylenel- erythromycin A Example 471 4-Nitro-lH-pyrazole-3-carboxamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 472 4,6-Dimethyl-2-oxo-2H-pyran-5-carboxamide of (llS.21R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino)-methylenel- erythromycin A Example 473 2-Amino-5-chloropyrimidine-4-carboxamide of (llS.21R.SV3-decladinosyl-ll.12- dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonvI-(2-(amino -ethylamino)-methylenel- ervthromvcin A Example 474 5-Methyl-lH-pyrazole-3-carboxamide of (llS.21-R.S)-3-decIadinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonvI-(2-(aminoVethylaminoVmethylenel-ervthromvcin A Example 475 l-Methyl-5-oxopyrrolidine-3-carboxamide of (llS,21--?.S)-3-decladinosyl-ll,12-dideoxy- 6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 476 2-Chloro-6-methyl-nicotinamide of (1 IS, 21_R.S)-3-decladinosyl-l 1 ,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino -methylenel-erythromvcin A Example 477 (4RV2-Thioxo-l,3-thiazoϋdine-4-carboxamide of (llS.21R.S)-3-decladinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel- erythromycin A Example 478 2,2-Dimethyl-5-oxotetrahvdrofnran-3-carboxamide of (llS.21R.S)-3-decladinosyl-11.12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonvI-(2-(amino -ethylamino -methylenel- erythromycin A Example 479 2,4-Dioxo-l,2,3,4-tetrahvdropyrimidine-5-carboxamide of (HS.21-R.S)-3-decIadinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(a--tύnoVethylammoV methylenel -erythromycin A Example 480 2-(Methoxycarbonyl-nicotinamide of (llS.21-R.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethvIamino)-methyIenel-ervthromycin A Example 481 2-MethvI-1.8-naphthyridine-3-carboxamide of (HS.21-R.S.-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel- ervthromvcin A Example 482 2-(Trifluoromethyl -l,6-naphthyridine-3-carboxamide of (llS,2ϋ-,SV3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(aminoVethylaminoV methylenel -erythromycin A Example 483 l-Benzyl-5-oxopyrrolidine-3-carboxamide of (HS.21i?.-->)-3-decladinosyl-ll,12-dideoxy- 6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 484 3-(Aminocarbonyl)pyrazine-2-carboxamide of (1 lS.21-_?.--»)-3-decladinosyl-l 1,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel- erythromycin A Example 485 4-Amino-2-methylpyrimidine-5-carboxamide of (HS.21-g.»y)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino -methylenel- erythromycin A Example 486 Isoxazole-5-carboxamide of (1 lS,21_R.S)-3-decIadinosyl-l l,12-dideoxy-6-O-methvI-3- oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino -methylenel-erythromvcin A Example 487 5-Methylisoxazole-3-carboxamide of (llS.21-R.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methvIenel-erythromvcin A Example 488 6-Cyanonicotinamide of (llS,21-R.SV3-decIadinosvI-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonvI-f2-(amino -ethvIamino)-methylenel-ervthromycin A Example 489 l-Ethyl-3-methyl-lH-pyrazole-5-carboxamide of (llS.21 J R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methvI-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino)-methylenel- erythromycin A Example 490 5-Methylisoxazole-4-carboxamide of (llS.21i-:.Sl-3-decladinosyl-11.12-dideoxy-6-0- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino -methylenel-ervthromvcin A Example 491 5-Oxo-l-(thien-2-ylmethylVpyrrolidine-3-carboxamide of (1 IS.2 l_R.SV3-decladinosyI- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)- methylenel-erythromycin A Example 492 2-(Pyridin-2-ylcarbonylVbenzamide of (llS,21-R,SV3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methvIenel-ervthromycin A Example 493 l-(2-Furylmethyl)-5-oxopyrrolidine-3-carboxamide of (llS.21R.SV3-decladinosvI-ll.12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonvI-(2-(aminoVethyIaιmnoVmethylenel- erythromycin A Example 494 5-(MethoxycarbonvIVpyridine-2-carboxamide of (llS.21i-.SV3-decladinosyl-ll.12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino -methylenel- erythromycin A Example 495 2-(4-Methyl-1.2,3-thiadiazol-5-yl -l,3-thiazole-4-carboxamide of (11S.21.R.SV3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)- ethylamino -methylenel -erythromycin A Example 496 3-Oxo-2,3-dihvdro-lH-indazole-4-carboxamide of (llS.21-R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylaminoVmethylenel- erythromycin A Example 497 2-Methyl-l,6-naphthyridine-3-carboxamide of iS.21-g.S)-3-decIadinosyl-11.12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethvIamino)-methyIenel- ervthromvcin A Example 498 4-MethyI-2-pyridin-4-yl-l,3-thiazoIe-5-carboxamide of (llS,21i-',SV3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)- methylenel-erythromycin A Example 499 4-MethyI-2-pyridin-3-yl-l,3-thiazole-5-carboxamide of (HS,21-R.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino - methylenel-erythromycin A Example 500 4-(MorphoIin-4-ylmethyl)-benzamide of (llS,21-R.S)-3-decladinosyI-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino)-methylene1-erythromvcin A Example 501 6-(lH-Imidazol-l-ylVnicotinamide of fllS.21-R.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino -methylenel-ervthromvcin A Example 502 5-Methoxy-2-(1.3.5-trimethyl-lH-pyrazol-4-ylVbenzamide of (11S.21-R.SV3- decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyI-(2-(amino)- ethylamino)-methyIenel -erythromycin A Example 503 4-Methyl-2-pyrazin-2-yl-l,3-thiazole-5-carboxamide of (HS.2LR.SV3-decIadinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino)-ethylamino)- methylenel -erythromycin A Example 504 2,5-Dimethyl-l_?-- r -pyrrole-3-carboxamide of (llS.21-R.S)-3-decladinosyl-ll,12-dideoxy-6- O-methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino -ethvIamino -methylene1-ervthromycin A Example 505 4-1 [(4,6-Dimethylpyrimidin-2-yl aminol carbonyl .-5-methylisoxazole-3-carboxamide of (llS,21i?. r l-3-decIadinosyl-11.12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2- (aminoVethylamino Vmethylenel -erythromycin A Example 506 l-Methyl-lH-pyrazole-4-carboxamide of (llS.21i?.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylene1-ervthromycin A Example 507 5-Chloro-l-methyl-3-(trifluoromethylVlH-pyrazoIe-4-carboxamide of (llS,21-f?,S)-3- decladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino - ethylamino Vmethylenel -erythromycin A Example 508 l-Pyrimidin-2-ylpiperidine-4-carboxamide of (llS,21-R.SV3-decladinosyl-ll,12-dideoxy- 6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 509 l-Methyl-3-(trifluoromethylVlH-pyrazole-4-carboxamide of (HS.21R.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(aminoVethylaminoV methylenel -erythromycin A Example 510 (4RV2-Oxo-l,3-thiazolidine-4-carboxamide of (llS.21R.SV3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyI-(2-(amino -ethylamino)-methylenel- erythromycin A Example 511 (2S)-l-Acetylpyrrolidine-2-carboxamide of (llS.21R.S)-3-decIadinosyl-ll,12-dideoxy-6- O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 512 5-Nitro-furan-2-carboxamide of (llS.21i-.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl- 3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino)-methylenel-ervthromycin A Example 513 l-Methylpyrrolidine-2-carboxamide of (HS.21i_.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino)-ethylamino -methylenel-ervthromvcin A Example 514 4-Acetyl-3,5-dimethyl-lH-pyrrole-2-carboxamide of (llS.21-R.S)-3-decIadinosyl-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino)-methylenel- erythromycin A Example 515 6-Methylnicotinamide of (llS.21-g.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 516 6-Methyl-3,4-dihvdro-2H-pyran-5-carboxamide of fllS.21R.S.-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel- erythromycin A Example 517 2,7-Dimethylpyrazolofl,5-alpyrimidine-6-carboxamide of (HS.21ii-.S)-3-decladinosyl- ll,12-dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino)- methylenel -erythromycin A Example 518 4-Methyl-l,2.3-thiadiazole-5-carboxamide of (llS.21R.S)-3-decIadinosyl-11.12-dideoxy- 6-O-methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 519 4-(TrifluoromethylVnicotinamide of (llS.21-R.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino)-methylenel-erythromvcin A Example 520 4-Oxo-4H-chromene-2-carboxamide of (llS,21i-.SV3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 521 5-Amino-lH-pyrazole-4-carboxamide of (llS.21-R.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 522 2-Chloronicotinamide of (llS'.21R.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonyI-(2-(amino)-ethvIamino -methylenel-erythromvcin A Example 523 2-Oxo-2i-- r -pyran-5-carboxamide of (llS.21-R.S)-3-decIadinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 524 Furan-3-carboxamide of (llS.21-R.-- )-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo- 12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 525 l,2,3-Thiadiazole-4-carboxamide of (llS.21-R,SV3-decladinosyl-ll,12-dideoxy-6-0- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethvIamino)-methylenel-ervthromvcin A Example 526 l,5-Dimethyl-lH-pyrazole-3-carboxamide of (llS,21-R.SV3-decladinosyl-ll,12-dideoxy- 6-0-methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 527 lH-Pyrazole-4-carboxamide of (HS.21-R.S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylene1-erythromvcin A Example 528 8-Methyl-4-oxo-4H-pyridoll,2-alpyrimidine-3-carboxamide of (llS.21i_.SV3- decladinosyl-1 l,12-dideoxy-6-O-methyl-3-oxo-12,l 1- [oxyearbonyl-(2-(aminoV ethylamino)-methylene1-ervthromycin A Example 529 2,6-Dimethoxynicotinamide of (llS,21-R,S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 530 4-Chloro-l,3-dimethyl-lH-pyrazolof3,4-b1pyridine-5-carboxamide of (HS,21R,S)-3- decladinosyl-l l,12-dideoxy-6-O-methyl-3-oxo-12,l 1- [oxycarbonyl-(2-(aminoV ethylamino)-methvIenel -erythromycin A Example 531 2-Methylnicotinamide of (llS.21R.S)-3-decIadinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonyl-(2-(amino)-ethvIamino -methylene1-ervthromycin A Example 532 5-Amino-2,6-dioxo-l,2,3,6-tetrahvdropyrimidine-4-carboxamide of (11S.21-R.SV3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)- ethylamino)-methylenel -erythromycin A Example 533 4-Hvdroxy-3-(morpholin-4-ylmethylVbenzamide of (HS,21i?.S.-3-decladinosyl-11.12- dideoxy-6-O-methvI-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethylamino)-methylenel- erythromycin A Example 534 5-MethvIpyrazine-2-carboxamide of (llS.21-R.SV3-decIadinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12.11-foxycarbonyl-(2-(amino)-ethvIamino)-methylenel-ervthromvcin A Example 535 6-Oxo-l,4,5,6-tetrahvdropyridazine-3-carboxamide of (llS.21-g.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel- ervthromvcin A Example 536 lH-pyrrole-2-carboxamide of (llS.21i_.S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,ll-[oxycarbonyl-(2-(aminoVethvIaminoVmethylenel-ervthromvcin A Example 537 2,2-DimethvI-4-oxo-3,4-dihvdro-2H-pyran-6-carboxamide of (US,21R,S)-3- decladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-.oxycarbonyl-(2-(aminoV ethylamino)-methylenel-ervthromycin A Example 538 l-Methyl-lH-pyrrole-2-carboxamide of (HS.21i?.S.-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonvI-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 539 2,3-Dihvdro-l,4-benzodioxine-2-carboxamide of (llS.21-R.S)-3-decladinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethvIamino)-methylenel- erythromycin A Example 540 2,4-Dimethyl-l,3-thiazole-5-carboxamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6- 0-methyl-3-oxo-12,ll-foxycarbonyl-(2-(aminoVethylamino)-methylenel-ervthromvcin A Example 541 l-Methyl-l,2,5,6-tetrahvdropyridine-3-carboxamide of (HS.21-R.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)- methylenel-erythromycin A Example 542 l-Oxy-pyridine-2-carboxamide of (llS.21J?.S)-3-decladinosyl-11.12-dideoxy-6-O- methyl-3-oxo-12,l 1-f oxycarbonyl-(2-(amino)-ethylamino -methylenel -erythromycin A Example 543 l-Acetylpiperidine-4-carboxamide of (HS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethylamino)-methylenel-erythromycin A Example 544 Tetrahvdrofuran-3-carboxamide of (1 lS.21-R,SV3-decIadinosyl-l l,12-dideoxy-6-O- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylene1-erythromycin A Example 545 (2SV5-Oxopyrrolidine-2-carboxamide of (llS,21R,SV3-decIadinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino)-methylene1-ervthromycin A Example 546 6-Hydroxynicotinamide of (llS,21i?.S)-3-decladinosvI-ll,12-dideoxy-6-O-methvI-3-oxo- 12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methvIenel-ervthromycin A Example 547 3,6-Dichloropyridazine-4-carboxamide of (llS,21-R.SV3-decladinosyl-11.12-dideoxy-6- O-methvI-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethvIamino)-methylene1-ervthromvcin A Example 548 l-Ethyl-7-methvI-4-oxo-l,4-dihvdro-l,8-naphthyridine-3-carboxamide of (llS,21R,S)-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(aminoV ethyIamino)-methylenel -erythromycin A Example 549 Furan-2-carboxamide of (llS,21i?.SV3-decladinosvI-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-[oxycarbonyl-(2-(aminoVethylaminoVmethvIene1-ervthromycin A Example 550 Pyridine-2-carboxamide of (llS,21i_.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonyl-(2-(amino)-ethyIamino)-methyleneI-ervthromvcin A Example 551 Nicotinamide of (llS,21i?.SV3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll- f oxycarbonyl-(2-(ammoVethylaminoVmethylenel -erythromycin A Example 552 Tetrahydrofuran-2-carboxamide of (llS.21-R.SV3-decIadinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,l 1- [oxycarbonyl-(2-(amino)-ethylamino -methylenel -erythromycin A Example 553 2-Methyl-furan-3-carboxamide of (1 lS.21i-.SV3-decladinosyl-l 1.12-dideoxy-6-O- methyl-3-oxo-12.11-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 554 (2-RVTetrahvdrofuran-2-carboxamide of (llS.21i?.S.-3-decIadinosyl-ll,12-dideoxy-6-Q- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 555 2-(5-OxopyrroMin-2-vIsulfanylVbenzamide of (llS.21R.S)-3-decladinosyl-ll,12- dideo-w-6-O-methvI-3-oxo-12,ll-ro-wcarbonyl-(2-(a--tιino)-ethylamino)-methyIenel- erythromycin A Example 556 l-AIlyl-2-oxo-l,2-dihvdropyridine-3-carboxamide of (HS.21R,S)-3-decladinosyl-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-roxycarbonvI-(2-(amino)-ethvIamino)-methvIenel- erythromycin A Example 557 2-Methyl-4-(trifluoromethyl)-l,3-thiazole-5-carboxamide of (HS,21R.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino -ethylamino - methylenel-erythromycin A Example 558 6-Hydroxy-l-methyl-2-oxo-l,2-dihvdropyrimidine-4-carboxamide of (11S.21R.SV3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)- ethylamino -methylenel -erythromycin A Example 559 3-MethvIisoxazole-4-carboxamide of (llS.21i?.S)-3-decladinosyl-ll,12-dideoxy-6-0- methyl-3-oxo-12,ll-foxycarbonyI-(2-(amino -ethylamino)-methylenel-ervthromvcin A Example 560 5-Methoxy-l,3-oxazole-2-carboxamide of (llS.21 J R,S)-3-decIadinosyl-ll,12-dideoxy-6-Q- methyl-3-oxo-12,l 1- f oxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A Example 561 2- r6-(AcetvIa--αino)-pyridin-3-yIsulfanyll-nicotinamide of (llS.21-R.S)-3-decladinosyI- 11.12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(aminoVethylamino)- methylenel-ervthromycin A Example 562 4-(4-MethvIpiperazin-l-yl)-3-nitro-benzamide of (llS.21_R.S)-3-decladinosyl-ll,12- dideoxy-6-0-methvI-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methyIenel- erythromvcin A Example 563 4-Isopropyl-l,2,3-thiadiazole-5-carboxamide of (llS,21-R.S)-3-decIadinosyI-ll,12- dideo-w-6-0-methyl-3-oxo-12,ll-fo-wcarbonyl-(2-(a---ι--no)-ethvIa--ιιino)-methylene1- erythromycin A Example 564 3-Oxo-2-phenyl-2,3-dihydropyridazine-4-carboxamide of (llS.2LR,SV3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethylamino)- methylenel -erythromycin A Example 565 5-Bromo-2-oxo-l,2-dihydropyridine-3-carboxamide of (llS,21R.S)-3-decladinosyl-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino -methylenel- erythromycin A Example 566 l-(Methoxycarbonyl piperidine-4-carboxamide of (llS,21_g.S)-3-decladinosyl-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethvIamino -methyIenel- erythromycin A Example 567 l-(6-Chloropyridazin-3-yl)piperidine-4-carboxamide of (11S.2 l--?.SV3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino - methylenel-erythromvcin A Example 568 4-Chloro-6-oxo-l-phenyl-l,6-dihydropyridazine-3-carboxamide of (llS.21-R,S)-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-i2,ll-foxycarbonyl-(2-(amino)- ethylamino Vmethylenel -erythromycin A Example 569 l-(3-Chlorophenyl -4-methoxy-6-oxo-l,6-dihvdropyridazine-3-carboxamide of (llS.21iϋ.S)-3-decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2- (amino)-ethvIamino)-methylenel-ervthromycin A Example 570 (l-MethvI-4-nitro-li__ r -pyrazol-5-yl)-acetamide of (HS.21R.S)-3-decladmosyl-ll,12- dideoxy-6-0-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethyIaminoVmethylene1- erythromvcin A Example 571 (1.3-Dimethyl-2,6-dioxo-2,3.6,7-tetrahvdro-lH-purin-8-yl -acetamide of (11S.21R.SV3- decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)- ethylaminol-methylenel-erythromvcin A 5 Example 572 5-Oxo-4,5-dihydrofuran-3-carboxamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6- Q-methyl-3-oxo-12,ll-roxycarbonyl-(2-(ai--uno)-ethylamino)-methvIenel-ervthromvcin A Example 573 10 2R,4SV4-(AcetyloxyVl,3-oxathiolane-2-carboxamide of (HS,21R.S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)- methylenel-erythromycin A Example 574 15 3-Hvdroxyisonicotinamide of (HS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino -methylenel-ervthromvcin A Example 575 3-Hvdroxypyridine-2-carboxamide of (llS.2ϋ_.S)-3-decladinosyl-ll,12-dideoxy-6-O- 20 methyl-3-oxo-12,ll-roxycarbonvI-(2-(amino)-ethylamino)-methylene]-erythromvcin A Example 576 2-Hydroxynicotinamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo- 12,ll-foxycarbonvI-(2-(amino)-ethylamino)-methylenel-ervthromycin A 25 Example 577 7-Hydroxy-4-oxo-4H-chromene-2-carboxamide of (HS.21i-,S)-3-decIadinosyl-ll,12- dideoxy-6-O-methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino -ethylamino -methylenel- ervthromycin A oυ Example 578 1-Oxy-nicotinamide of (llS.21i_.S)-3-decladinosyl-ll,12-dideoxy-6-0-methvI-3-oxo- 12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromvcin A 35 Example 579 lH-Indole-2-carboxamide of (llS.21-R,S)-3-decladinosvI-ll,12-dideoxy-6-O-methyl-3- oxo-12,ll-foxycarbonyl-(2-(a----ino)-ethylamino)-methylene1-erythromycin A Example 580 0 5-Metho-w---H-indole-2-carboxamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino)-ethvIamino)-methylenel-ervthromvcin A Example 581 6-chloro-4-oxo-4H-chromene-2-carboxamide of (llS.21R,S)-3-decladinosyl-ll,12- dideoxy-6-O-methyI-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethyIamino)-methyIenel- erythromycin A Example 582 Ouinoline-2-carboxamide of (llS.21_--:,S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino -methylene1-ervthromycin A Example 583 4-Hvdroxy-6-methoxyquino_ine-2-carboxamide of (1 S.2 l-g,S)-3-decladinosyl-l 1,12- dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino)-ethylamino)-methylene1- erythromycin A Example 584 4-Methyl-3-oxo-3,4-dihvdroquinoxaline-2-carboxamide of (llS,21R,S)-3-decladinosyl- ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-roxycarbonyl-(2-(amino -ethylamino)- methylenel-ervthromycin A Example 585 4-(2-Hvdro-wethylV3-oxo-3,4-dihvdroqu__aoxaHne-2-carboxamide of (HS.21i-!.S)-3- decladinosyl-ll,12-dideoxy-6-O-methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)- ethylamino)-methvIenel-ervthromycm A Example 586 3-Methoxyquinoxaline-2-carboxamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6-0- methyl-3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 587 1-Benzo an-2-carboxamide of (1 lS.21R,SV3-decladinosyl-l l,12-dideoxy-6-Q-methyl- 3-oxo-12,ll-roxycarbonyl-(2-(amipo)-ethylamino)-methylene1-erythromycin A Example 588 6-Ethyl-5-oxothiomorphoIine-3-carboxamide of (llS,21i-.S)-3-decladinosyl-ll,12- dideo-^-6-O-methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethvIammo)-methylenel- erythromycin A Example 589 2-Chloro-l-oxy-nicotinamide of (1 lS.21R.SV3-decladinosyl-l l,12-dideoxy-6-O-methyl- 3-oχo-12,ll-loxycarbonyl-(2-(amino -ethylamino -methylenel-ervthromvcin A Example 590 Oxo-(thien-2-yl)-acetamide of (llS,21_f_.S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3- oxo-12.11-roxycarbonvI-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 591 Oxo-(phenyl)-acetamide of (HS.21R.S)-3-decIadinosyl-l l,12-dideoxy-6-O-methyl-3-oxo- 12,ll-foxycarbonyl-(2-(amino)-ethvIamino)-methylene1-ervthromvcin A Example 592 3-(2-Nitrophenyl)-2-oxo-propionamide of (llS.21R.S)-3-decladinosyl-ll,12-dideoxy-6- 0-methyl-3-oxo-12,ll-roxycarbonyl-(2-(a----ύιo)-ethvIaminoVmethvIenel-ervthromvcin A Example 593 3-(lH-IndoI-3-ylV2-oxo-propionamide of (llS.21-R.S)-3-decladinosyI-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-ervthromycin A Example 594 2-Oxo-3-phenyl-propionamide of (llS,21R.S)-3-decIadinosyl-ll,12-dideoxy-6-0-methyl- 3-oxo-12,ll-foxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 595 (2EV3-(lH-Imidazol-4-vIVacrvIamide of (llS.21_g.S)-3-decIadinosyl-11.12-dideoxy-6-0- methyl-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethyIamino)-methylene1-ervthromycin A Example 596 (2E)-3-(lH-Indol-3-ylVacrylamide of (llS.21R.S)-3-decladinosyl-11.12-dideoxy-6-0- methvI-3-oxo-12,ll-foxycarbonvI-(2-(amino)-ethylamino)-methyIene1-ervthromvcin A Example 597 3-(l,3-Benzodioxol-5-yl)prop-2-ynamide of (HS.21R.S)-3-decIadinosyl-ll,12-dideoxy-6- 0-methvI-3-oxo-12,ll-foxycarbonvI-(2-(amino -ethylaι__ no)-methylenel-erythromvcin A Example 598 (2EV3-Ouinoϋn-3-yl-acrylamide of (llS.21i_.S)-3-decladinosyl-l 1.12-dideoxy-6-0- methyl-3-oxo-12,ll-[oxycarbonyl-(2-(amino)-ethylamino)-methylenel-erythromvcin A Example 599 (2EV3-Quinolin-2-vI-acrylaι_-ide of (llS.21i-.S)-3-decladinosyl-ll,12-dideox>^-6-0- methvI-3-oxo-12,ll-[oxycarbonvI-(2-(amino)-ethylamino)-methylene1-ervthromycin A Example 600 (OuinoxaIin-2-ylsulfanyl)-acetamide of (llS t 21R,S)-3-decladinosyl-ll,12-dideoxy-6-O- methyl-3-oxo-12,ll-loxycarbonyl-(2-(amino)-ethylamino -methyIenel-ervthromvcin A Example 601 r5-(5-Nitro-furan-2-yl)-fl.3,41oxadiazol-2-yIsulfanvn-acetamide of (11S.21R.SV3- decladinosyl-ll,12-dideoxy-6-0-methvI-3-oxo-12,ll-foxycarbonyl-(2-(amino - ethylamino Vmethylenel -erythromycin A Example 427-601 were obtained starting from example 13 (5 mg) by following the same procedure as reported for Example 426. The name and amount of starting material (i.e carboxylic acid) and LC MS analysis (retention time and m/z) of examples 427-601 are reported in table 6. Table 6 Pharmacy examples Tablets g/tab Active ingredient 320 Lactose 150 Ethyl cellulose 20 Sodium lauryl sulphate 7 Magnesium stearate 3 Tablet core 500 The active ingredient and the lactose are blended together and then granulated using water as granulating fluid. The dried granules are blended with ethyl cellulose, sodium lauryl sulphate and magnesium stearate and the tablet core formed using an appropriate punch. The tablet may be coated using conventional technique and coatings. Injection The sterile vials were filled with the sterile active ingredient (500 mg). Purge the vial head space with sterile nifrogen; close the vials using rubber and metal overseals. The product may be constituted by dissolving in water for injection(10 ml) or other suitable sterile vehicle for injection shortly before administration. Activity data The value of MIC (microbial inhibition concentration), obtained according to NCCLS (National Committee for Clinical Laboratory Standards), of the preferred compounds of the invention against erythromycin susceptible Streptococcus pneumoniae and Streptococcus pyogenes are less then or equal to 1 ug/ml. In particular Examples 70, 56, 54, 49, 51, 58, 75, 66, 47, 52, 117 showed MIC<*=0.1 ug ml against erythromycin susceptible Streptococcus pneumoniae strains. Furthermore Examples 70, 56, 54, 49, 51, 58, 75, 66, 47, 52, 117 showed MIC in the range <= 8 - 0.06ug/ml against erythromycin resistant Streptococcus pneumoniae strains.

Claims: Claims A compound of formula (1) (I) wherein R is hydrogen, cyano, (CE-2) n A- -R4 or (CH2) n 5; A is a group selected from -N(Rg , -N[C(0)Rg]-, -N(Rg)C(0)-, -N(Rg)S(0) 2 -, - N(R )C(0)0-, -N=C(Rg)- or -NCRg)C(Y)N(R 7 )-; Ri is C _g alkyl or C - alkenyl; R2 is hydrogen or a hydroxyl protecting group; R3 is hydrogen or halogen; X is a bond, a C _ o alkylene, a C2-10 alkenylene or a C2-.10 alkynylene chain wherein said chains are: i) optionally interrupted by a bivalent radical group selected from -0-, -N(R )-, - C(O)-, -N(R 8 )C N(R 9 )-, -S(O)m-, -N(R 8 )C(0)-, -C(0)N(R 8 )-, -N(R 8 )C(0)C(0)-, -C(0)0- or -C(NORgj- and/or ii) optionally substituted by one or two groups selected from: C _4 alkyl, oxo, Cχ-4 alkoxy, halogen, cyano, phenoxy, hydroxy, NR R9, N(R 8 )C(O)R 9 , =NORg, NE. 8 C(Y)N--l9 or optionally substituted phenyl; R4 is selected from: hydrogen, optionally substituted phenyl, optionally substituted C3.7 cycloalkyl, optionally substituted 9 to 10 membered fused bicyclic carbocyclic, optionally substituted 5 or 6 membered heteroaryl in which the 5 -membered heteroaryl contains at least one heteroatom selected from oxygen, sulphur or nifrogen and the 6- membered heteroaryl group contains from 1 to 3 nitrogen atoms, optionally substituted 5-6 membered heterocyclic, or R4 is an optionally substituted 9 or 10 membered fused bicyclic heterocyclic having at least ' one heteroatom selected from oxygen, sulphur or nitrogen; R5 is a 5 or 6 membered heterocyclic containing at least one nifrogen, optionally substituted by one or two groups selected from oxo or 9 or 10 membered fused bicyclic heterocyclic having at least one heteroatom selected from oxygen, sulphur or nitrogen; Rg and R7 are independently hydrogen, Ci .4 alkyl or phenyl which is optionally substituted by one or two Cj .4 alkyl groups; R 8 and R9 are independently hydrogen, phenyl (which may be substituted by one or two Cχ_ 4 alkyl) or Rg and R9 are independently C _4 alkyl which is optionally substituted by 1 or 2 groups selected from: phenyl, Ci .4 alkoxy, cyano, 5-membered heteroaryl containing 1 or 2 heteroatoms selected from oxygen, sulphur or nitrogen or the 6-membered heteroaryl group contains from 1 to 3 nifrogen atoms, hydroxy, oxo, carboxy; Y is an oxygen or a sulphur atom; n is 0 or an integer from 1 to 3; m is 0, 1 or 2; and pharmaceutically acceptable salts and solvates thereof. 2. A compound as claimed in claim 1 wherein R is (CH2) n A-X-R4 or (CH 2 ) n R 5 . 3. A compound as claimed in claim 1 or 2 wherein R is methyl or 2-propenyl. 4. A compound as claimed in any claims 1 to 3 wherein R2 is hydrogen. 5. A compound as claimed in any claims 1 to 4 wherein R3 is hydrogen or fluorine. 6. A compound as claimed in any claims 1 to 5 wherein A is selected from - NH-, -NHC(O)- or -NHC(Y)NH-. 7. A compound as claimed in any claims 1 to 6 wherein X is a Cχ_4 alkylene chain which is optionally interrupted by a bivalent radical selected from -0-, -NH-, -C(0)-, - NHC(O)-, -S(0)2- -S- and /or such a Cχ_4 alkylene chain is optionally substituted by one group selected from ML?, Cχ.4 alkyl, oxo or N-OH. 8. A compound as claimed in any claims 1 to 7 wherein R4 is phenyl (optionally substituted by 1 to 3 groups which may be the same or different selected from nitro, amino, methyl, C1..4 alkoxy ie methoxy or hydroxy), 1-imidazolyl (optionally substituted by 1 to 3 groups which may be the same or different selected from pyridin-2-yl, pyridin-3-yl , pyridin-4-yl , phenyl, m-nifrophenyl, dichlorophenyl, Cχ_4 alkyl i.e methyl, trifluoromethylphenyl, thiophen-2-yl, thiazol-2-yl), 3-trifluoromethylρyrazol-4-yl, 1- pyrazolyl (optionally substituted by 1 to 3 groups which may be the same or different selected from alogen (i.e. chlorine, fluorine), pyridin-2-yl, pyridin-4-yl, quinolin-2-yl, quinolin-4-yl, quinoxalin-2-yl, pyrimidin-4-yl, C1 -4 alkyl i.e methyl, 1,3 benzooxazol-2-yl, , p-chloro phenyl, difluoro phenyl,pyrazin-2-yl thiazol-5-yl,) lH-indol-3-yl, lH-indol-2-yl, 3-methoxy- quinoxalin-2-yl, 2-quinolinyl 3-quinolinyl, 4-quinolinyl, 4-pyridinyl, 3-pyridinyl(optionally substituted ' by one amino), 5methyl furan-2-yl, 3-thiophenyl, 6-methoxy-7H-purin-7-yl, quinoxalin-2-yl, 3-methoxy quinoxalin-2-yl 6-methoxy-2-oxol, 3-benzoxazol-3(2H)-yl, 1H- pyrrolo[2,3-b]pyridin-l-yl, 2-(methylthio)-lH-benzimidazol-l-yl, l,3-dioxo-l,3~dihydro-2H- isoindol-2-yl, 6-methoxy-2-oxo-l,3-benzoxazol-3(2H)-yl, 3H-imidazo[4,5-b]pyridin-3-yl, l,3-benzoxazol-2-yl, benzothiazol-2-yl, 1,3 benzo[l,3]dioxolyl, 3-(5-cyano-3,4- dimethylthien-2-yl)- 1 H- 1 ,2,4-friazol- 1 -yl, 2,3 -dihy dro-benzo [ 1 ,4] dioxin-6-yl, 2,4-dimethyl- l,3-thiazol-5-yl or 4-oxo-4,5,6,7-tefrahydro-benzo[b]thiophen-2-yl. 9. A compound as claimed in any claims 1 to 8 wherein R is methyl, R2 or R3 is hydrogen, A is -NH-, -NHC(O)-, X is C .4 alkylene chain which is optionally interrupted by a bivalent radical selected from -O-, -NH-, -C(O)-, -NHC(O)-, -S(0)2- -S- and /or such a C _4 alkylene chain is optionally substituted by one group selected from NH2 > C1 -4 alkyl, oxo or N-OH, R4 is a group selected from 4-(pyridin-3-yl)-imidazol-l-yl, 4-(pyridin-3-yl)- imidazol-l-yl, quinoxalin-2-yl, quinoxalin-2-yl, quinolin-4-yl, quinoxalin-2-yl, -(2,3-dihydro- benzo[l ,4]dioxin-6-yl, 4-oxo-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, 4~methoxy-3 -nitrophenyl, 2-hydroxy-4,5-dimethoxy-phenyl, 3-hydroxy-4-methoxy-phenyl, 3,4-dimethoxy- phenyl, 4-hydroxy-3 -methoxy-phenyl, 3-methoxy-quinoxalin-2-yl, 3-amino-4-methoxy- phenyl, 4-(pyridin-3-yl)-imidazol-l-yl, quinolin-4-yl, 4-pyrimidin-4-yl-pyrazol-l-yl, 2- (methylthio)-lH-benzimidazol-l-yl, -[3-(4-chlorophenyl)-lH-pyrazol-5-yl]propylamino)- ' methylene], 6-methoxy-2-oxo-l,3-benzoxazol-3(2H)-yl, lH-pyrrolo[2,3-b]pyridin-l-yl, 3- (2,4-dimethyl-l,3-thiazol-5-yl)-lH-pyrazol-l -yl, 4-phenyl-lH-imidazol-l-yl, 4-pyridin-4-yl- IH-imidazol-l-yl, thiophen-2-yl, 3-(5-cyano-3,4-dimethylthien-2-yl)-lH-l,2,4-triazol-l-yl, quinolin-3-yl, l,3-thiazol-2-yl and n is 0 or 1. 10. A compounds selected from: (11 S,21S)-3-decladinosyl-l 1, 12-dideoxy-6-0-methyl-3-oxo-12, 1 l-[oxycarbonyl-(2-(4- (jyridin-3-yl)-infrdazol-l-yl)-ethylamino)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2- (quinolin-4-yl)-ethylamino)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- ( yridin-3-yl)-imidazol-l-yl)-propylamino)-methylene]-e_ythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(2- (quinoxalin-2-ylsulfanyl)-acetamido)-methylene]-erythromycin A; (US, 21S)-3-decladinosyl-ll,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-((4-(2,3- dihydro-benzo[l,4]dioxin-6-yl)-4-oxo)-butyramido)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(4- methox3 r -3 -nifro-phen} )-4-oxo-butyran_ido)-methylene] -erythromycin A; (l lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,ll-[oxycarbonyl-(4-(2- hydroxy-4,5-dimethoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(4-oxo- 4,5,6J-tefrahydro-benzo[b]thiophen-2-yl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- quinolin-2-yl- 1 H-pyrazol- 1 -yJ)propylamino)-methylene] -erythromycin A; (1 lS,21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3 -oxo- 12,1 l-[oxycarbonyl-(4-(3,4- dimethoxy-phenyl)-4-oxo-butyramido)-methylene]-erythromycin A; (1 IS, 21S)-3-decladinosyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(4-(4- hydroxy-3 -methoxy-phenyl)-4-oxo-butyramido)-methylene] -erythromycin A; (1 IS, 21S)-3-decladinθsyl-l l,12-dideoxy-6-0-methyl-3-oxo-12,l l-[oxycarbonyl-(3-(4- (thiophen-2-yl)-imidazol- 1 -yl)-propylamino)-methylene]-erythromycin A. 11. A process for the preparation of a compound of formula (I) which comprises: a) reacting a compound of formula (T_) wherein Ri , R 2 , 3 have the meanings defined in claim 1, \ is a cladinose derivative of formula (HI), in which R2 a is a hydroxy protecting group, or hydroxy, 2 is hydrogen or R | - together R12 is an oxygen atom, with a suitable activated derivative of the acid (IV), HOC(0)XR4 (IV) or with a suitable activated derivative of the sulfonic acid (V) HOS(0)2-X 4 (V) respectively wherein R4 and X have the meanings defined in claim 1, to produce a compound of formula (I) wherein R is (QB-2) n A-X-R4, A is -N(Rg)C(0)- or - N(Rg)S(0)2- X and n have the meanings defined in claim 1; b) reacting a compound of formula (-3) with a compound of formula R4 N(Ry)C(Y)L (VI), wherein L is a suitable leaving group, Rg is phenyl or Cχ_4 alkyl, R4 and X have the meanings defined in claim 1, to produce a compound of formula (I) wherein R is (CH2) n A- X-R4, A is -N(Rg)C(Y)N(R7)-and X and n have the meanings defined in claim 1; c) reacting a compound of formula (TJ) with a compound of formula R4XN=C(Y) (V-T), wherein 4 and X have the meanings defined in claim 1, to produce a compound of formula (I) wherein R is CH2) n A-X-R4, A is -N(Rg)C(Y)NH-, X and n have the meanings defined in claim 1; d) reacting a compound of formula (II) with a compound of formula R4XL (VTH), wherein R4 and X have the meanings defined in claim 1 and L is suitable leaving group, to produce a compound of formula (I) wherein R is (CH2) n A-X-R4, A is -N(Rg)-, X and n have the meanings defined in claim 1; e) reacting a compound of formula (II) with a compound of formula R4XOC(0)L (LX) wherein L is a suitable leaving group such as halogen (e.g. chlorine or bromine), R4 and X have the meanings defined in claim 1, to produce a compound of formula (I) wherein R is (CH2) n A-X-R4, A is N(Rg)C(0)0, X and n have the meanings defined in claim 1; f) reacting a compound of formula (II) with a compound of formula R4XCHO (X), wherein R4 and X have the meanings defined in claim 1, to produce a compound of formula (I) wherein R is (CH2) n A-X-R4 , A is N=C(Rg), X and n have the meanings defined in claim 1; g) reacting a compound of formula (XI), in which j \ and Rχ 2 have the meaning as defined for compounds of formula (H), wherein R\, R2, R3, R4 and X have the meanings defined in claim 1, with a compound of formula RgCOOH (XIa), to produce a compound of formula (J) wherein R is (CH 2 ) n A-X-R4, A is N=C(Rg), X and n have the meanings defined in claim 1; h) decarboxylation of a compound of formula (XS), wherein R\, R 2 and R3 have the meanings defined in claim 1, Ri 1 and R 2 have the meaning as defined for compounds of formula (IT), (XS) to produce a compound of formula (I) wherein R is hydrogen; i) cyclisation of chlorine derivatives (XIII) wherein Ri , R2 and R3 have the meanings defined in claim 1, Ri 1 and Ri 2 have the meaning as defined for compounds of formula (H), xm) to produce a compound of formula (I) wherein R is cyano; 1) reacting a compound of formula (XVTJ), wherein Rχ ; R2 and R3 have the meanings defined in claim 1, Ri 1 and R12 have the meaning defined in formula (H) and R 3 is C1.4 alkyl, with an aldehyde of formula (xvn) (XVIH) wherein R4, X and n have the meanings defined in claim 1, to produce a compound of formula(I) wherein R is (CH2) n AXR4 A and X have the meanings defined in claim 1 ; and n is an integer from 2 or 3; m) reacting a compounds of formula (I) in which has the meanings defined in claim 1, R3 is hydrogen and R2 is hydroxy protecting group with a halogenating agent to produce a compound of formula (I) wherein R3 is halogen; n) cyclisation of a compound of formula (XXXIT), wherein L is suitable leaving group such halogen (i.e chlorine or bromine), R j , R2 , R3 have the meanings defined in claim 1, Ri 1 and R 2 have the meaning defined in formula (H), X is C4..5 alkylene chain optionally substituted by one or two groups selected from oxo, 9 or 10 membered fused bicyclic heterocyclic having at- least one heteroatom selected from oxygen, sulphur or nifrogen, (XXXD) to produce a compound of formula (I) wherem Ri is (CH 2 ) n R5; and thereafter, if required, subjecting the resulting compound to one or more of the following operations: i) hydrolysis of the cladinose derivative (SI); ii) conversion of the 3-hydroxy group into the 3-oxo; iii) removal of the protecting group R2 and iv) conversion of the resultant compound of formula (I) into a pharmaceutically acceptable salt and solvates thereof. 12. A compound as claimed in any claims 1 to 10 for use in therapy. 13. The use of a compound as claimed in any claims 1 to 10 in the preparation of a medicament for use in the therapy of systemic or topical bacterial infections in a human or animal body. 14. . The use of a compound as claimed in any claims 1 to 10 for use in the freatment or prophylaxis of systemic or topical bacterial infections in a human or animal body. 15. A pharmaceutical composition comprising a compound as claimed in any claims 1 to 10 in admixture with one or more pharmaceutically acceptable carriers or excipients. 16. A method for the treatment of the human or non human animal body to combat bacterial infection comprising administration of an effective amount of a compound as claimed in in any claims 1 to 10.

Inventors: ANDREOTTI DANIELE, ARISTA LUCA, BIONDI STEFANO, CARDULLO FRANCESCA, DAMIANI FREDERICA, LOCIURO SERGIO, MARCHIORO CARLA, MERLO GIANCARLO, MINGARDI ANNA, NICCOLAI DANIELA, PAIO ALFREDO, PIGA ELISABETTA, POZZAN ALFONSO, SERI CATIA, TARSI LUCA, TERRENI SILVIA, TIBASCO JESSICA, ANDREOTTI, DANIELE, ARISTA, LUCA, BIONDI, STEFANO, CARDULLO, FRANCESCA, DAMIANI, FREDERICA, LOCIURO, SERGIO, MARCHIORO, CARLA, MERLO, GIANCARLO, MINGARDI, ANNA, NICCOLAI, DANIELA, PAIO, ALFREDO, PIGA, ELISABETTA, POZZAN, ALFONSO, SERI, CATIA, TARSI, LUCA, TERRENI, SILVIA, TIBASCO, JESSICA
Applicants: ANDREOTTI DANIELE, ARISTA LUCA, BIONDI STEFANO, CARDULLO FRANCESCA, DAMIANI FREDERICA, GLAXO GROUP LTD, LOCIURO SERGIO, MARCHIORO CARLA, MERLO GIANCARLO, MINGARDI ANNA, NICCOLAI DANIELA, PAIO ALFREDO, PIGA ELISABETTA, POZZAN ALFONSO, SERI CATIA, TARSI LUCA, TERRENI SILVIA, TIBASCO JESSICA, ANDREOTTI, DANIELE, ARISTA, LUCA, BIONDI, STEFANO, CARDULLO, FRANCESCA, DAMIANI, FREDERICA, GLAXO GROUP LIMITED, LOCIURO, SERGIO, MARCHIORO, CARLA, MERLO, GIANCARLO, MINGARDI, ANNA, NICCOLAI, DANIELA, PAIO, ALFREDO, PIGA, ELISABETTA, POZZAN, ALFONSO, SERI, CATIA, TARSI, LUCA, TERRENI, SILVIA, TIBASCO, JESSICA
Application year: 2001
Main classification: C07H17
IPC codes: A61K31, A61P31, C07H17