SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES

Abstract: The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing caridovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

Description: SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 1. Field of The Invention The present invention relates to sulfoxide and bis-sulfoxide compounds; c compositions comprising the sulfoxide or bis-sulfoxide compounds; and methods for treating or preventing a disease or disorder, for example, cardiovascular disease, dyslipidemia; dyslipoproteinemia; a disorder of glucose metabolism; Alzheimer's Disease; Syndrome X; a peroxisome proliferator activated receptor-associated disorder; septicemia; a thrombotic disorder; obesity; pancreatitis; hypertension; renal disease; cancer; 1 ^ inflammation; and impotence. The compounds of the invention can also treat or prevent inflammatory processes and diseases like gastrointestinal disease, irritable bowel syndrome (IBS), inflammatory bowel disease (Crohn's Disease, ulcerative colitis), arthritis (rheumatoid arthritis, osteoarthritis), autoimmune disease (systemic lupus erythematosus, etc.), scleroderma, ankylosing spondylitis, gout and pseudogout, muscle pain: , < - polymyositis/polymyalgia rheumatica/fibrositis; infection and arthritis, juvenile rheumatoid arthritis, tendonitis, bursitis and other soft tissue rheumatism. The sulfoxide and bis- sulfoxide compounds and compositions of the invention may also be used to reduce the fat content of meat in livestock and reduce the cholesterol content of eggs. 2. Background of The Invention Obesity, hyperlipidemia, and diabetes have been shown to play a causal role in atherosclerotic cardiovascular diseases, which currently account for a considerable proportion of morbidity in Western society. Further, one human disease, termed "Syndrome X" or "Metabolic Syndrome", is manifested by defective glucose metabolism (insulin c resistance), elevated blood pressure (hypertension), and a blood lipid imbalance (dyslipidemia). See e.g. Reaven, 1993, Annu. Rev. Med. 44:121-131. The evidence linking elevated serum cholesterol to coronary heart disease is overwhelming. Circulating cholesterol is carried by plasma lipoproteins, which are particles of complex lipid and protein composition that transport lipids in the blood. Low density - 0 lipoprotein (LDL) and high density lipoprotein (HDL) are the major cholesterol-carrier proteins. LDL is believed to be responsible for the delivery of cholesterol from the liver, where it is synthesized or obtained from dietary sources, to extrahepatic tissues in the body. The term "reverse cholesterol transport" describes the transport of cholesterol from extrahepatic tissues to the liver, where it is catabolized and eliminated. It is believed that ~ < - plasma HDL particles play a major role in the reverse transport process, acting as scavengers of tissue cholesterol. HDL is also responsible for the removal of non-cholesterol lipid, oxidized cholesterol and other oxidized products from the bloodstream. Atherosclerosis, for example, is a slowly progressive disease characterized by the accumulation of cholesterol within the arterial wall. Compelling evidence supports the belief that lipids deposited in atherosclerotic lesions are derived primarily from plasma ,- apolipoprotein B (apo B)-containing lipoproteins, which include chylomicrons, CLDL, IDL and LDL. The apo B-containing lipoprotein, and in particular LDL, has popularly become known as the "bad" cholesterol, contrast, HDL serum levels correlate inversely with coronary heart disease. Indeed, high serum levels of HDL are regarded as a negative risk factor. It is hypothesized that high levels of plasma HDL are not only protective against . „ coronary artery disease, but may actually induce regression of atherosclerotic plaque (e.g. , see Badimon et ah, 1992, Circulation 86:(Suppl. πi)86-94; Dansky and Fisher, 1999, Circulation 100:1762-3.). Thus, HDL has popularly become known as the "good" cholesterol. , - 2.1. Cholesterol Transport The fat-transport system can be divided into two pathways: an exogenous one for cholesterol and triglycerides absorbed from the intestine and an endogenous one for cholesterol and triglycerides entering the bloodstream from the liver and other non-hepatic tissue. „ hi the exogenous pathway, dietary fats are packaged into lipoprotein particles called chylomicrons, which enter the bloodstream and deliver their triglycerides to adipose tissue for storage and to muscle for oxidation to supply energy. The remnant of the chylomicron, which contains cholesteryl esters, is removed from the circulation by a specific receptor found only on liver cells. This cholesterol then becomes available again for cellular 2 < r metabolism or for recycling to extrahepatic tissues as plasma lipoproteins. In the endogenous pathway, the liver secretes a large, very-low-density lipoprotein particle (VLDL) into the bloodstream. The core of NLDL consists mostly of triglycerides synthesized in the liver, with a smaller amount of cholesteryl esters either synthesized in the liver or recycled from chylomicrons. Two predominant proteins are displayed on the surface of NLDL, apolipoprotein B-100 (apo B-100) and apolipoprotein E (apo E), although other apolipoproteins are present, such as apolipoprotein Cm (apo Ciri) and apolipoprotein Ql (apo Cπ). When a NLDL reaches the capillaries of adipose tissue or of muscle, its triglyceride is extracted. This results in the formation of a new kind of particle called intermediate-density lipoprotein (IDL) or NLDL remnant, decreased in size and enriched in ~ < - cholesteryl esters relative to a NLDL, but retaining its two apoproteins. h human beings, about half of the DDL particles are removed from the circulation quickly, generally within two to six hours of their formation. This is because IDL particles bind tightly to liver cells, which extract IDL cholesterol to make new NLDL and bile acids. The HDL not taken up by the liver is catabolized by the hepatic lipase, an enzyme bound to the proteoglycan on liver cells. Apo E dissociates from IDL as it is transformed to LDL. - Apo B-100 is the sole protein of LDL. Primarily, the liver takes up and degrades circulating cholesterol to bile acids, which are the end products of cholesterol metabolism. The uptake of cholesterol-containing particles is mediated by LDL receptors, which are present in high concentrations on hepatocytes. The LDL receptor binds both apo E and apo B-100 and is responsible for 1 ^ binding and removing both IDL and LDL from the circulation. In addition, remnant receptors are responsible for clearing chylomicrons and NLDL remnants i.e., HDL). However, the affinity of apo E for the LDL receptor is greater than that of apo B-100. As a result, the LDL particles have a much longer circulating life span than DDL particles; LDL circulates for an average of two and a half days before binding to the LDL receptors in the , r liver and other tissues. High serum levels of LDL, the "bad" cholesterol, are positively associated with coronary heart disease. For example, in atherosclerosis, cholesterol derived from circulating LDL accumulates in the walls of arteries. This accumulation forms bulky plaques that inhibit the flow of blood until a clot eventually forms, obstructing an artery and causing a heart attack or stroke. 2 Ultimately, the amount of intracellular cholesterol liberated from the LDL controls cellular cholesterol metabolism. The accumulation of cellular cholesterol derived from NLDL and LDL controls three processes. First, it reduces the cell's ability to make its own cholesterol by turning off the synthesis of HMGCoA reductase, a key enzyme in the cholesterol biosynthetic pathway. Second, the incoming LDL-derived cholesterol promotes 2 storage of cholesterol by the action of chlolesterol acyltransferase ("ACAT"), the cellular enzyme that converts cholesterol into cholesteryl esters that are deposited in storage droplets. Third, the accumulation of cholesterol within the cell drives a feedback mechanism that inhibits cellular synthesis of new LDL receptors. Cells, therefore, adjust their complement of LDL receptors so that enough cholesterol is brought in to meet their Q metabolic needs, without overloading (for a review, see Brown & Goldstein, hi, The Pharmacological Basis Of Therapeutics, 8th Ed., Goodman & Gihnan, Pergamon Press, New York, 1990, Ch. 36, pp. 874-896). High levels of apo B-containing lipoproteins can be trapped in the subendothelial space of an artery and undergo oxidation. The oxidized lipoprotein is recognized by ~.c scavenger receptors on macrophages. Binding of oxidized lipoprotein to the scavenger receptors can enrich the macrophages with cholesterol and cholesteryl esters independently of the LDL receptor. Macrophages can also produce cholesteryl esters by the action of ACAT. LDL can also be complexed to a high molecular weight glycoprotein called apolipoprotein(a), also known as apo(a), through a disulfide bridge. The LDL-apo(a) complex is known as Lipoprotein(a) or Lp(a). Elevated levels of Lp(a) are detrimental, having been associated with atherosclerosis, coronary heart disease, myocardial infarction, stroke, cerebral infarction, and restenosis followmg angioplasty. 2.2. Reverse Cholesterol Transport Peripheral (non-hepatic) cells predominantly obtain their cholesterol from a combination of local synthesis and uptake of preformed sterol from NLDL and LDL. Cells 1 I expressing scavenger receptors, such as macrophages and smooth muscle cells, can also obtain cholesterol from oxidized apo B-containing lipoproteins. h contrast, reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for recycling to extrahepatic tissues, hepatic storage, or excretion into the intestine in bile. The RCT pathway represents the only means of eliminating cholesterol , t- from most extrahepatic tissues and is crucial to maintenance of the structure and function of most cells in the body. The enzyme in blood involved in the RCT pathway, lecithimcholesterol acyltransferase (LCAT), converts cell-derived cholesterol to cholesteryl esters, which are sequestered in HDL destined for removal. LCAT is produced mainly in the liver and 2 circulates in plasma associated with the HDL fraction. Cholesterol ester transfer protein (CETP) and another lipid transfer protem, phospholipid transfer protein (PLTP), contribute to further remodeling the circulating HDL population (see for example Bruce et ah, 1998, Annu. Rev. Nutr. 18:297-330). PLTP supplies lecithin to HDL, and CETP can move cholesteryl ester made by LCAT to other lipoproteins, particularly apoB-containing 2 < - lipoproteins, such as NLDL. HDL triglyceride can be catabolized by the extracellular hepatic triglyceride lipase, and lipoprotein cholesterol is removed by the liver via several mechanisms. Each HDL particle contains at least one molecule, and usually two to four molecules, of apolipoprotein (apo A-I). Apo A-I is synthesized by the liver and small r intestine as preproapolipoprotein which is secreted as a proprotein that is rapidly cleaved to generate a mature polypeptide having 243 amino acid residues. Apo A-I consists mainly of a 22 amino acid repeating segment, spaced with helix-breaking proline residues. Apo A-I forms three types of stable structures with lipids: small, lipid-poor complexes referred to as pre-beta-1 HDL; flattened discoidal particles, referred to as pre-beta-2 HDL, which contain o ,- only polar lipids (e.g. , phospholipid and cholesterol); and spherical particles containing both polar and nonpolar lipids, referred to as spherical or mature HDL (HDL 3 and HDL 2 ). Most HDL in the circulating population contains both apo A-I and apo A-II, a second major HDL protein. This apo A-I- and apo A-H-containing fraction is referred to herein as the AJ/AH- HDL fraction of HDL. But the fraction of HDL containing only apo A-I, referred to herein as the AI-HDL fraction, appears to be more effective in RCT. Certain epidemiologic studies support the hypothesis that the AI-HDL fraction is antiartherogenic (Parra et ah, 5 1992, Arterioscler. Thromb. 12:701-707; Decossin et ah, 1997, Eur. J. Clin. Invest. 27:299- 307). Although the mechanism for cholesterol transfer from the cell surface is unknown, it is believed that the lipid-poor complex, pre-beta-1 HDL, is the preferred acceptor for cholesterol transferred from peripheral tissue involved in RCT. Cholesterol newly j . transferred to pre-beta-1 HDL from the cell surface rapidly appears in the discoidal pre- beta-2 HDL. PLTP may increase the rate of disc formation (Lagrost et ah, 1996, J. Biol. Chem. 271 : 19058- 19065), but data indicating a role for PLTP in RCT is lacking. LCAT reacts preferentially with discoidal and spherical HDL, transferring the 2-acyl group of lecithin or phosphatidylethanolamine to the free hydroxyl residue of fatty alcohols, r particularly cholesterol, to generate cholesteryl esters (retained in the HDL) and lysolecithin. The LCAT reaction requires an apoliprotein such apo A-I or apo A-IV as an activator. ApoA-I is one of the natural cofactors for LCAT. The conversion of cholesterol to its HDL- sequestered ester prevents re-entry of cholesterol into the cell, resulting in the ultimate removal of cellular cholesterol. Cholesteryl esters in the mature HDL particles of the AI- 2 Q HDL fraction are removed by the liver and processed into bile more effectively than those derived from the A /AII-HDL fraction. This may be due, in part, to the more effective binding of AI-HDL to the hepatocyte membrane. Several HDL receptors have been identified, the most well characterized of which is the scavenger receptor class B, type I (SR-BI) (Acton et ah, 1996, Science 271:518-520). The SR-BI is expressed most 2^ abundantly in steroidogenic tissues (e.g., the adrenals), and in the liver (Landshulz et ah, 1996, J. Clin. Invest. 98:984-995; Rigotti et ah, 1996, J. Biol. Chem. 271:33545-33549). Other proposed HDL receptors include HB1 and HB2 (Hidaka and Fidge, 1992, Biochem J. 15: 161-7; Kurata et ah, 1998, J. Atherosclerosis and Thrombosis 4: 112-7). While there is a consensus that CETP is involved in the metabolism of NLDL- and ~r, LDL-derived lipids, its role in RCT remains controversial. However, changes in CETP activity or its acceptors, NLDL and LDL, play a role in "remodeling" the HDL population. For example, in the absence of CETP, the HDL becomes enlarged particles that are poorly removed from the circulation (for reviews on RCT and HDLs, see Fielding & Fielding, 1995, J. Lipid Res. 36:211-228; Barrans et ah, 1996, Biochem. Biophys. Ada. 1300:73-85: 35 Hirano et ah, 1991 , Arterioscler. Thromb. Vase. Biol. 17:1053-1059). 2.3. Reverse Transport of Other Lipids HDL is not only involved in the reverse transport of cholesterol, but also plays a role in the reverse transport of other lipids, i.e., the transport of lipids from cells, organs, and tissues to the liver for catabolism and excretion. Such lipids include sphingomyelin, oxidized lipids, and lysophophatidylcholine. For example, Robins and Fasulo (1997, J s- Clin. Invest. 99:380-384) have shown that HDL stimulates the transport of plant sterol by the liver into bile secretions. 2.4. Peroxisome Proliferator Activated Receptor Pathway Peroxisome proliferators are a structurally diverse group of compounds that, when . r. administered to rodents, elicit dramatic increases in the size and number of hepatic and renal peroxisomes, as well as concomitant increases in the capacity of peroxisomes to metabolize fatty acids via increased expression of the enzymes required for the β-oxidation cycle (Lazarow and Fujiki, 1985, Ann. Rev. Cell Bioh 1:489-530; Namecq and Draye, 1989, Essays Biochem. 24:1115-225; andΝelali et α/., 1988, Cancer Res. 48:5316-5324). 1 ,- Chemicals included in this group are the fibrate class of hypolipidermic drugs, herbicides, and phthalate plasticizers (Reddy and Lalwani, 1983, Crit. Rev. Toxicoh 12:1-58). Peroxisome proliferation can also be elicited by dietary or physiological factors, such as a high-fat diet and cold acclimatization. Insight into the mechanism whereby peroxisome proliferators exert their pleiotropic 2 effects was provided by the identification of a member of the nuclear hormone receptor superfamily activated by these chemicals (Isseman and Green, 1990, Nature 347:645-650). This receptor, termed peroxisome proliferator activated receptor α (PPAR , was subsequently shown to be activated by a variety of medium and long-chain fatty acids. PPAR α activates transcription by binding to DΝA sequence elements, termed peroxisome 2_- proliferator response elements (PPRE), in the form of a heterodimer with the retinoid X receptor (RXR). RXR is activated by 9-cis retinoic acid (see Kliewer et ah, 1992, Nature 358:771-774; Gearing et ah, 1993, Proc. Natl. Acad. Sci. USA 90:1440-1444, Keller et ah, 1993, Proc. Natl. Acad. Sci. USA 90:2160-2164; Heyman et ah, 1992, Cell 68:397-406, and Levin et ah, 1992, Nature 355:359-361). Since the discovery of PPAR α , additional 3 Q isoforms of PPAR have been identified, e.g. , PPAR p , PPAR γ and PPAR δ , which have similar functions and are similarly regulated. PPREs have been identified in the enhancers of a number of gene-encoding proteins that regulate lipid metabolism. These proteins include the three enzymes required for peroxisomal β-oxidation of fatty acids; apolipoprotein A-I; medium-chain acyl-CoA ~c dehydrogenase, a key enzyme in mitochondrial β-oxidation; and aP2, a lipid binding protein expressed exclusively in adipocytes (reviewed in Keller and Whali, 1993, TEM, 4:291-296; see also Staels and Auwerx, 1998, Atherosclerosis 137 Suppl:S19-23 . The nature of the PPAR target genes coupled with the activation of PPARs by fatty acids and hypolipidemic drugs suggests a physiological role for the PPARs in lipid homeostasis. None of the commercially available cholesterol management drugs has a general utility in regulating lipid, lipoprotein, insulin and glucose levels in the blood. Thus, - compounds that have one or more of these utilities are clearly needed. Further, there is a clear need to develop safer drugs that are efficacious at lowering serum cholesterol, increasing HDL serum levels, preventing coronary heart disease, and/or treating existing disease such as atherosclerosis, obesity, diabetes, and other diseases that are affected by lipid metabolism and/or lipid levels. There is also a clear need to develop drugs that may be , r, used with other lipid-altering treatment regimens in a synergistic manner. There is still a further need to provide useful therapeutic agents whose solubility and Hydrophile/Lipophile Balance (HLB) can be readily varied. Citation or identification of any reference in Section 2 of this application is not an admission that such reference is available as prior art to the present invention. 15 3. Summary of The Invention In one embodiment, the invention relates to a compound of the formula I: or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, 2^ geometric isomer or mixtures thereof, wherein (a) each occurrence of Z is independently CH 2 , CH=CH, or phenyl, where each occurrence of m is independently an integer ranging from 1 to 9, but when Z is phenyl then its associated m is 1; 30 (b) G is (CH 2 ) X , where x is 2, 3, or 4, CH 2 CH=CHCH 2 , CH=CH, CH 2 -phenyl-CH 2 , or phenyl; (c) W 1 and W 2 are independently L, V, C(R 1 )(R 2 )-(CH 2 ) -C(R 3 )(R 4 )-(CH 2 ) -Y, or o r C(R 1 )(R 2 )-(CH 2 ) C -V where c is 1 or 2 and n is an integer ranging from 0 to 4; (d) each occurrence of R 1 or R 2 is independently (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl or when one or both of W 1 and W 2 is C(R 1 )(R 2 )-(CH 2 ) c -C(R 3 )(R 4 )-(CH 2 ) n -Y, then R 1 and R 2 can both be H to form a methylene group; (e) R 3 is H, ( -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, phenyl, benzyl, Cl, Br, CN, NO 2 , or CF 3 ; (f) R 4 is OH, ( - alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, ( - alkoxy, phenyl, benzyl, Cl, Br, CN, NO 2 , or CF 3 ; (g) L is QR^MCH^-Y; (g) V is: (h) each occurrence of Y is independently OH, COOH, CHO, COOR 5 , SO 3 H, wherein: (i) R 5 is (C j -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (C 1 -C 6 )alkoxy, or phenyl groups, (ii) each occurrence of R 6 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, (Cj-C 6 ) alkoxy, or phenyl groups; and (iii) each occurrence of R 7 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl. In another embodiment, the invention relates to a compound of the formula la: la or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) each occurrence of Z is independently CH 2 or CH=CH, wherein each occurrence of m is independently an integer ranging from 1 to 9; (b) G is (CH 2 ) X , CH 2 CH=CHCH 2 , or CH=CH, where x is 2, 3, or 4; 5 (c) W 1 and W 2 are independently L, N, or COR-^MCH^-N, where c is 1 or 2; (d) each occurrence of R 1 and R 2 is independently (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl; i n (e) L is C(R 1 )(R 2 )-(CH 2 ) n -Y, where n is an integer ranging from 0 to 4; (f) V is: 5 (g) each occurrence of Y is independently OH, COOH, CHO, COOR 3 , SO 3 H, 0 5 wherein: (i) R 3 is ( - alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (C 1 -C 6 )alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (C j -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, (Cι-C 6 ) alkoxy, or phenyl groups; and (iii) each occurrence of R 5 is independently H, (C j -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl. Preferably, in formula la each occurrence of Y is independently OH, COOR 3 , or COOH. In yet another embodiment, the invention relates to a compound of the formula lb lb or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein: (a) each occurrence of m is independently an integer ranging from 1 to 9; (b) x is 2, 3, or 4; (c) each occurrence of n is independently an integer ranging from 0 to 4; (d) each occurrence of R 1 and R 2 is independently (C j -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl; and (e) each occurrence of Y is independently OH, COOH, CHO, COOR 3 , SO 3 H, ™- 10 wherein: (i) R 3 is (C,-C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or 15 benzyl and is unsubstituted or substituted with one or more halo, OH, (C 1 -C 6 )alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (C,-C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted 20 with one or two halo, OH, - alkoxy, or phenyl groups; and (iii) each occurrence of R 5 is independently H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl. 2 5 Preferably in formula lb, each occurrence of Y is independently OH, COOR 3 , or COOH. In still another embodiment, the invention relates to a compound of the formula Ic Ic or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein: o (a) each occurrence of m is an independent integer ranging from 1 to 9; (b) x is 2, 3, or 4; (c) V is: In another embodiment, the invention relates to a compound of the formula II: II or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) each occurrence of R 1 or R 2 is independently (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or R 1 or R 2 are both H, or R 1 , R 2 , and the carbon to which they are both attached are taken together to form (C 3 -C 7 )cycloalkyl group; (b) each occurrence of n is independently an integer ranging from 1 to 5; (c) each occurrence of m is independently an integer ranging from 0 to 4; (d) W 1 and W 2 are independently CH 2 OH, C(O)OH, CHO, OC(O)R 3 , C(O)OR 3 , SO 3 H, wherein: (i) R 3 is (C j -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, ( -C^alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (C j -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, Cγ-C 6 alkoxy, or phenyl groups; and (iii) each occurrence of R 5 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl. h another embodiment, the invention relates to a compound of the formula Ila: Ila or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) R 1 and R 2 are OH, COOH, CHO, COOR 7 , SO 3 H, wherein: (i) R 7 is ( - alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, ( -C^alkoxy, or phenyl groups, 5 (ii) each occurrence of R 8 is independently H, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, - alkoxy, or phenyl groups, , (ϋi) each occurrence of R 9 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl; (b) R 3 and R 4 are (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl; 15 (c) R 5 and R 6 are H, halogen, ( -C alkyl, ( -C alkoxy, (C6)aryloxy, CN, or NO 2> N(R 5 ) 2 where R 5 is H, (C j - ) alkyl, phenyl, or benzyl; (d) each occurrence of m is independently an integer ranging from 1 to 5; (e) each occurrence of n is independently an integer ranging from 0 to 4; and (f) C* 1 and C* 2 represent independent chiral-carbon centers wherein each center may 2 independently be R or S. Preferred compounds of formula Ila are those wherein each occurrence of R 1 and R 2 is independently OH, COOR 7 , or COOH. Other preferred compounds of formula Ila are those wherein m is 0. Other preferred compounds of formula Ila are those wherein m is 1. 5 Other preferred compounds of formula Ila are those wherein R 1 and/or R 2 is C(O)OH or CH 2 OH. Other preferred compounds of formula Ila are those wherein R 3 and R 4 are each independently (C j - ) alkyl. Other preferred compounds of formula Ila are those wherein R 3 and R 4 are each 30 methyl. Other preferred compounds of formula Ila are those wherein C* 1 is of the stereochemical configuration R or substantially R. Other preferred compounds of formula Ila are those wherein C* 1 is of the stereochemical configuration S or substantially S. 35 Other preferred compounds of formula Ha are those wherein C* 2 is of the stereochemical configuration R or substantially R. Other preferred compounds of formula Ila are those wherein C* 2 is of the stereochemical configuration S or substantially S. hi a particular embodiment, compounds of formula Ila are those wherein C* 1 C* 2 are of the stereochemical configuration (S\S 2 ) or substantially (S'jS 2 ). In another particular embodiment, compounds of formula Ila are those wherein C* 1 C* 2 are of the stereochemical configuration (S^R 2 ) or substantially (S^R 2 ). In another particular embodiment, compounds of formula Ila are those wherein C* 1 C* 2 are of the stereochemical configuration (R ,R 2 ) or substantially (R ! ,R 2 ). In another particular embodiment, compounds of formula Ila are those wherein C* 1 C* 2 are of the stereochemical configuration (R'jS 2 ) or substantially (R^S 2 ). In yet another embodiment, the invention relates to a compound of the formula III III or a pharmaceutically acceptable salt, hydrate, solvate, clatlirate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein: (a) each occurrence of Z is independently CH 2 , CH=CH, or phenyl, where each occurrence of m is independently an integer ranging from 1 to 5, but when Z is phenyl then its associated m is 1 ; (b) G is (CH 2 ) X , CH 2 CH=CHCH 2 , CH=CH, CH 2 -phenyl-CH 2 , or phenyl, where x is an integer ranging from 1 to 4; ( c ) W 1 and W 2 are independently C(R 1 )(R 2 )-(CH 2 ) n -Y, where n is an integer ranging (d) each occurrence of R 1 and R 2 is independently (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl or R 1 and R 2 are both H; (e) each occurrence of R 6 and R 7 is independently H, (C r C 6 ) alkyl, or R 6 and R 7 can be taken together to form a carbonyl group; (e) Y is OH, COOH, CHO, COOR 3 , SO 3 H, wherein: (i) R 3 is (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (C j -C^alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, C j -C 6 alkoxy, or phenyl groups; (iii) each occurrence of R 5 is independently H, (C j -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl; and (f) each occurrence of p is independently 0 or 1 where the broken line represents an optional presence of one or more additional carbon-carbon bonds that when present complete one or more carbon-carbon double bonds. Preferably in formula III, each occurrence of W 1 and W 2 is an independent C(R 1 )(R 2 )-(CH 2 ) n -Y group and each occurrence of Y is independently OH, COOR 3 , or COOH. h yet another embodiment, the invention relates to a compound of the formula Ilia: Ilia or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) each occurrence of m is independently an integer ranging from 1 to 5; (b) x is an integer ranging from 1 to 4; (c) W 1 and W 2 are independently C(R 1 ) R 2 )-(CH 2 ) Il -Y, where n is an integer ranging from 0 to 4 ; (d) each occurrence of R 1 or R 2 is independently (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl; (e) Y is (CH 2 ) n OH, (CH 2 ) n COOH, (CH 2 ) n CHO, (CH 2 ) n COOR 3 , SO 3 H, wherein: (i) R 3 is (C j -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (Cι-C 6 )alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, C j -C 6 alkoxy, or phenyl groups, (iii) each occurrence of R 5 is independently H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl; and (f) each occurrence of p is independently 0 or 1. Preferably in compound Ilia, W 1 and W 2 are independent C(R 1 )(R 2 )-(CH 2 ) n -Y, groups and each occurrence of Y is independently OH, COOR 3 , or COOH. The compounds of the invention are useful in medical applications for treating or preventing cardiovascular diseases, dyslipidemias, dyslipoproteinemias, disorders of glucose metabolism, Alzheimer's Disease, Syndrome X, PPAR-associated disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal diseases, cancer, inflammation, and impotence. As used herein, the phrase "compounds of the invention" means, collectively, the compounds of formulas I, II, and III and pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomer, racemates or mixtures of stereoisomers thereof. Compounds of formula I encompass subgroup formulas la, lb, and Ic. Compounds of formula II encompass subgroup formula Ila and compounds of formula III encompass subgroup formula Ilia. Thus, "compound of the invention" collectively means compound of formulas I, la, lb, Ic, II, Ha, III, and Ilia and pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomer, racemates or mixtures of stereoisomers thereof. The compounds of the invention are identified herein by their chemical structure and/or chemical name. Where a compound is referred to by both a chemical structure and a chemical name, and the chemical structure and chemical name conflict, the chemical structure is determinative of the compound's identity. 3.1. Brief Description of the Drawings FIG. 1 is a graph of the Effects of Two Weeks of Daily Oral Gavage Treatment on Lipoprotein Total Cholesterol in Chow-Fed Obese Female Zucker Rats. FIG. 2 is a table of the Effects of Two Weeks of Daily Oral Gavage Treatment in Chow-Fed Obese Female Zucker Rats. FIG. 3 is a graph of 14C-Acetate Incorporation Into Saponified and Non-saponified lipids. 4. Detailed Description of the Invention The present invention provides novel compounds useful for treating or preventing a cardiovascular disease, dyslipidemia, dyslipoproteinemia, a disorder of glucose metabolism, Alzheimer's Disease, Syndrome X, a PPAR-associated disorder, septicemia, a thrombotic disorder, obesity, pancreatitis, hypertension, a renal disease, cancer, inflammation, and impotence. In this regard, the compounds of the invention are particularly useful when incorporated in a pharmaceutical composition having a carrier, excipient, diluent, or a mixture thereof. A composition of the invention need not contain additional ingredients, such as an exicpient, other than a compound of the invention. Accordingly, in one embodiment, the compositions of the invention can omit pharmaceutically acceptable excipients and diluents and can be delivered in a gel cap or drug delivery device. Accordingly, the present invention provides methods for treating or preventing cardiovascular diseases, dyslipidemias, dyslipoproteinemias, disorders of glucose 5 metabolism, Alzheimer's Disease, Syndrome X, PPAR-associated disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal diseases, cancer, inflammation, or impotence, comprising administering to a patient in need thereof a therapeutically effective amount of a compound or composition of the invention. In certain embodiments of the invention, a compound of the invention is , n administered in combination with another therapeutic agent. The other therapeutic agent provides additive or synergistic value relative to the administration of a compound of the invention alone. The therapeutic agent can be a lovastatin; a thiazolidmedione or fϊbrate; a bile-acid-binding-resin; a niacin; an anti-obesity drug; a hormone; a tyrophostine; a sulfonylurea-based drug; a biguanide; an α-glucosidase inhibitor; an apolipoprotein A-I 15 agonist; apolipoprotein E; a cardiovascular drug; an HDL-raising drug; an HDL enhancer; or a regulator of the apolipoprotein A-I, apolipoprotein A-IN and/or apolipoprotein genes. Some of the preferred compounds of the invention are listed in Table I below. TABLE 1: Compounds of the Invention 20 25 1-1 4- [4-(3 -Hydroxy-3 -methyl-butane- 1 -sulfinylmethyl)-phenylmethanesulfmyl] -2- methyl-butan-2-ol 1-2 4-[4-(4-Hydroxy-3,3-dimethyl-butane-l-sulfinylmethyl)-phenylmethanesulfinyl]-2,2- ~ 5 dimethyl-butan- 1 -ol 1-3 -[4-(3-Carboxy-3-methyl-butane-l-sulfmylmethyl)-phenylmethanesulfinyl]-2,2-dimethyl- butyric acid 1-4 -[4-(3,3-Dimethyl-4-oxo-butane-l-sulfinylmethyl)-phenylmethanesulfmyl]-2,2-dimethyl- butyraldehyde 1-5 -[4-(3-Methoxycarbonyl-3-methyl-butane-l-sulfιnylmethyl)-phenylmethanesulfmyl]-2,2-di methyl-butyric acid methyl ester 1-6 2,2-Dimethyl-4-[4-(3-methyl-3-phenoxycarbonyl-butane-l-sulfinylmethyl)- phenylmethanesulfinyl] -butyric acid phenyl ester 1-7 4-[4-(3-Benzyloxycarbonyl-3-methyl-butylsulfanylmethyl)-benzylsulfanyl]-2,2-dimethyl- butyric acid benzyl ester 1-8 -Methyl-4-[4-(3-methyl-3-sulfo-butane-l-sulfinylmethyl)-phenylmethanesulfinyl]-butane-2 - sulfonic acid 1-9 Phosphoric acid mono-{l,l-dimethyl-3-[4-(3-methyl-3-phosphonooxy-butane-l-sulfinylmethyl)- phenylmethanesulfinyl] -propyl} ester 1-10 4-[4-(3-Hydroxy-3-methyl-butane-l-sulfinyl)-benzenesulfinyl]-2-methyl-butan-2-ol Ml -[4-(4-Hydroxy-3,3-dimethyl-butane-l-sulfinyl)-benzenesulfιnyl]-2,2-dimethyl-butan-l-ol 1-12 4-[4-(3-Carboxy-3-methyl-butane-l-sulfmyl)-benzenesulfinyl]-2,2-dimethyl-butyric acid 1-13 -[4-(3,3-Dimethyl-4-oxo-butane-l-sulfmyl)-benzenesulfmyl]-2,2-dimethyl-butyraldehyde 1-14 4-[4-(3-Methoxycarbonyl-3-methyl-butane-l-sulfmyl)-benzenesulfmyl]-2,2-dimethyl- butyric acid methyl ester 1-15 2,2-Dimethyl-4-[4-(3-methyl-3-phenoxycarbonyl-butane-l-sulfinyl)-benzenesulfinyl]- butyric acid phenyl ester 1-16 4-[4-(3-Benzyloxycarbonyl-3-methyl-butane-l-sulfmyl)-benzenesulfinyl]-2,2-dimethyl- butyric acid benzyl ester 1-17 -Methyl-4-[4-(3-methyl-3-sulfo-butane-l-sulfmyl)-benzenesulfinyl]-butane-2-sulfonic acid 1-18 Phosphoric acid mono-{l, l-dimethyl-3-[4-(3-methyl-3-phosphonooxy-butane-l-sulfmyl)- benzenesulfinylj-propyl} ester Ib-1 -> 4-[3-(3-Hydroxy-3-methyl-butane-l-sulfmyl)-propane-l-sulfinyl]-2-methyl-butan-2-ol HOH 2 C ft II CH 2 OH o O 0 . Ib-2 4-[3-(4-Hydroxy-3,3-dimethyl-butane-l-sulfinyl)-propane-l-sulfϊnyl]-2,2-dimethyl- butan-1-ol 5 HOOC ■/ ^ ""^^ " "~sS" ^ II" " " ^ " "sS" ^ II" ^ COOH O O Ib-3 4-[3-(3-Carboxy-3-methyl-butane-l-sulfinyl)-propane-l-sulfinyl]-2,2-dimethyl-butyric acid 0 OHC • s ^ ^ / ^ g. II II CHO 0 0 Ib-4 -> 4- [3 -(3 ,3 -Dimethyl-4-oxo-butane- 1 -sulfϊnyl)-propane- 1 -sulfinyl] -2,2- dimethyl-butyraldehyde Ib-5 4-[3-(3-Methoxycarbonyl-3-methyl-butane-l-sulfinyl)-propane-l-sulfinyl]-2,2- dimethyl-butyric acid methyl ester 5 Ib-6 2,2-Dimethyl-4-[3-(3-methyl-3-phenoxycarbonyl-butane-l-sulfinyl)-propane-l-sulfinyl]- butyric acid phenyl ester Ib-7 4-[3-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl- butyric acid benzyl ester H0 3 S' "S0 3 H II II 0 o Ib-8 2-Mefhyl-4- [3 -(3 -methyl-3 -sulfo-butane- 1 -sulfinyl)-propane- 1 -sulfϊnyl] -butane- 2-sulfonic acid Ib-9 Phosphoric acid mono- {1,1 -dimethyl-3- [3-(3 -methyl-3-phosphonooxy-butane- 1 -sulfinyl)-propane- 1 - sulfinylj-propyl} ester Ib-10 5-{l,l-Dimethyl-3-[3-(3-methyl-3-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dione}-buta ne-l-sulfmyl)-proρane-l-sulfϊnyl]-propyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione Ib-11 5-{l,l-Dimethyl-3-[3-(3-methyl-3-{3,3a-D yα^o-2H-thieno[3,2-c]pyridine-4,6-dithione}-b utane-l-sulfιnyl)-propane-l-sulfinyl]-propyl}-3,3a-dihydro-2H-thieno[3,2-c]ρyridine-4,6-dit hione Ib-12 4-[3-(3-Cyanocarbamoyl-3-methyl-butane-l-sulfinyl)-propane-l-sulfinyl]-2,2-dimethyl-buty rcyanimide Ib-13 Phosphoramidic acid mono-(3-{3-[3-(amino-hydroxy-phosphoryloxy)- 3 -methyl-butane- 1 -sulfinyl] -prop ane- 1 -sulfinyl} -1,1 -dimethyl-propyl) ester Ib-14 3-(Amino-hydroxy-phosphoryloxy)-3-methyl-l-[3-(3- {amino -hydroxy-phosphoryloxy}-3-methyl-butane-l-sulfinyl)-propane-l-sulfinyl]-butane Ib-15 l-{l,l-Dimethyl-3-[3-(3-methyl-3-{lH-tetrazol-l-yl}-butane-l-sulfinyl)-propane-l-sulfinyl ] -propyl } - 1 H-tetrazole Ib-16 1 - { 1 , 1 -Dimethyl-3 - [3 -(3 -methyl-3 - { 1 H-tetrazol-5-yl} -butane- 1 -sulfinyl)-pro ane- 1 -sulfinyl ] -propyl} - 1 H-tetrazole Ib-17 5- { 1 , 1 -Dimethyl-3-[3-(3- {Isoxazol-3-ol-5- yl}-3-methyl-butane-l-sulfmyl)-propane-l-sulfinyl]-propyl}-isoxazol-3-ol Ib-18 4- { 1 , 1 -Dimethyl-3-[3-(3- {Isoxazol-3-ol-4- yl}-3-methyl-butane-l-sulfϊnyl)-propane-l-sulfinyl]-propyl}-isoxazol-3-ol Ib-19 - { 1 ,1 -Dimethyl-3-[3-(3- {5-hydroxy-pyran-4-one-3-yl} -3-methyl-butane-l -sulfmyl)-propan e- 1 -sulfinyl] -propyl} -5 -hydroxy-pyran-4-one Ib-20 ^ 2-{l,l-Dimethyl-3-[3-(3-{5-hydroxy-pyran-4-one-2-yl}-3-methyl-butane-l-sulfmyl)-propan e-l-sulfinyl]-propyl}-5-hydroxy-pyran-4-one Ib-21 l-Ethyl-3-(3-{3-[3-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3-methyl-butane-l-sulfmyl]- propane- 1 -sulfinyl} -1,1 -dimethyl-propyl)-imidazolidine-2,4-dione 5 0 Ib _22 3- { 1 , 1 -Dimethyl-3-[3-(3- { 1 -ethyl-imidazolidine-2,4-dione-3-yl} -3 -methyl-butane- 1 -sulfinyl )-propane-l -sulfinyl] -propyl} -1 -ethyl-i idazolidine- 2,4-dione Ib-23 0 3- { 1 , 1 -Dimefhyl-3-[3-(3- { l-ethyl-imidazolidine-2-one-4- tMone-3-yl}-3-methyl-butane-l-sulfinyl)-propane-l-sulfinyl]-propyl}-l-ethyl-imidazolidine -2-one-4-thione 5 Ib-24 3- { 1 , 1 -Dimethyl-3-[3-(3- { l-ethyl-imidazolidine-4-one-2- thione-3-yl}-3-methyl-butane-l-sulfmyl)-propane-l-sulfmyl]-propyl}-l-ethyl-imidazolidine -4-one-2-thione Ib-25 5-[3-(5-Hydroxy-3,3-dimethyl-pentylsulfanyl)-ρropylsulfanyl]-3,3-dimethyl-pentan-l-ol Ib-26 5-[3-(4-Carboxy-3,3-dimethyl-butane-l-sulfinyl)-propane-l-sulfinyl]- 3,3-dimethyl-pentanoic acid OHC, / X / V Λ /V .CHO II II 0 0 Ib-27 5-[3-(3,3-Dimethyl-5-oxo-pentane-l-sulfinyl)-propane-l-sulfmyl]-3,3-dimethyl-pentanal Ib-28 5- [3 -(4-Methoxycarbonyl-3 ,3 -dimethyl-butane- 1 -sulfmyl)-propane- 1 -sulfinyl] -3 ,3 -dimethyl -pentanoic acid methyl ester Ib-29 ,3-Dimethyl-5-[3-(3-methyl-3-phenoxycarbonyl-butane-l-sulfmyl)-propane-l-sulfinyl]- pentanoic acid phenyl ester Ib-30 -[3-(3-Benzyloxycarbonyl-3-methyl-butane-l-sulfinyl)-propane-l-sulfmyl]-3,3-dimethyl- pentanoic acid benzyl ester Ib-31 -[3-(3,3-Dimethyl-4-sulfo-butane-l-sulfinyl)-propane-l-sulfmyl]-2,2-dimethyl-butane-l- sulfonic acid Ib-32 Phosphoric acid mono- {4-[3-(3,3-dimethyl-4-phosphonooxy-butane-l-sulfinyl)- propane-l-sulfmyl]-2,2-dimethyl-butyl} ester Ib-33 -{4-[3-(3,3-Dimethyl-4-{3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione}-butane-l-sulfi nyl)-proρane- 1 -sulfmyl]-2,2-dimethyl-butyl} -3 ,3 a-dihydro-2H- thieno[3,2-c]pyridine-4,6-dione Ib-34 -{4-[3-(3,3-Dimethyl-4-{3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-butane-l-su lfinyl)-propane- 1 -sulfιnyl]-2,2-dimethyl-butyl} -3 ,3 a-dihydro-2H- thieno[3,2-c]pyridine-4,6-dithione Ib-35 -[3-(4-Cyanocarbamoyl-3,3-dimethyl-butane-l-sulfmyl)-propane-l-sulfmyl]-3,3-dimethyl- pentanoic acid cyanamide Ib-36 Phosphoramidic acid mono-(4- {3-[4-(amino-hydroxy-phosphoryloxy)-3,3- dimethyl-butane-l-sulfinyl]-propane-l-sulfinyl}-2,2-dimethyl-butyl) ester Ib-37 1 - {4-[3-(3,3-Dimethyl-4- {tetrazol- 1 -yl} -butane- 1 -sulfinyl)-propane- 1 -sulfinyl] -2,2-dimethy 1-butyl} - lH-tetrazole Ib-38 l-{4-[3-(3,3-Dimethyl-4-{tetrazol-5-yl}-butane-l-sulfmyl)-propane-l-sulfinyl]-2,2-dimethy 1-butyl} -1 H-tetrazole Ib-39 5- {4-[3~(3,3-Dimethyl-4- {isoxazol-3-ol-5-yl} -butane-l-sulfmyl)-propane-l-sulfmyl]-2,2-di methyl-butyl} -isoxazol-3 -ol Ib-40 4-{4-[3-(3,3-Dimethyl-4-{isoxazol-3-ol-4-yl}-butane-l-sulfmyl)-propane-l-sulfmyl]-2,2-di methyl-butyl} -isoxazol-3 -ol Ib-41 3-{4-[3-(3,3-Dimethyl-4-{5-hydroxy-pyran-4-one -3-yl}-butane-l-sulfmyl)-propane-l-sulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one Ib-42 2- {4-[3-(3,3-Dimethyl-4- {5-hydroxy-ρyran-4-one -2-yl} -butane- 1 -sulfinyl)-proρane- l-sulfinyl]-2,2-dimethyl-butyl} -5-hydroxy-pyran-4-one OH , II II O O Ib-43 3- {4-[3-(3,3-Dimethyl-4- {5-Hydroxy-pyran-4-one -2-yl} -butane- 1 -sulfinyl)-propane- 1 -sulfinyl] -2,2-dimethyl-butyl} -5 -hydroxy-pyran-4-one Ib-44 l-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l-sulfmyl] -propane-l-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione Ib-45 l-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l-sulfmyl]- propane- 1 -sulfinyl} -2,2-dimethyl-butyl)-imidazolidine-2,4-dione Ib-46 l-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l-sulfinyl] -propane- 1 -sulfinyl} -2,2-dimethyl-butyl)-imidazolidine-2,4-dithione Ib-47 l-Ethyl-3-(4-{3-[4-(3-ethyl-2-oxo-5-thio-imidazolidin-l-yl)- ,3 -dimethyl-butane- 1 -sulfinyl] -propane- 1 -sulfinyl} -2,2-dimethyl-butyl)-imidazolidine-2- one-4-thione Ib-48 l-Ethyl-3-(4-{3-[4-(3-ethyl-2-thioxo-5- o-imidazolidin- 1 -yl)-3,3 -dimethyl-butane- 1 -sulfinyl] -propane- 1 -sulfinyl} -2,2-dimethyl-b utyl)-imidazolidine-2-thione-4-one Ib-49 4-[2-(3-Hydroxy-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2-methyl-butan-2-ol Ib-50 -[2-(4-Hydroxy-3,3-dimethyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butan-l-ol Ib-51 4.[2-(3-Carboxy-3-methyl-butane-l-sulfmyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid Ib-52 -Methyl-4- [2-(3 -methyl-3 -sulfo-butane- 1 -sulfinyl)-ethanesulfinyl] -butane-2-sulfonic acid Ib-53 4-[2-(3,3-Dimethyl-4-oxo-butane-l-sulfmyl)-ethanesulfmyl]-2,2-dimethyl-butyraldehyde Ib-54 -[2-(3-Methoxycarbonyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid methyl ester Ib-55 ,2-Dimethyl-4-[2-(3-methyl-3-phenoxycarbonyl-butane-l-sulfinyl)-ethanesulfinyl]-butyric acid phenyl ester Ib-56 4-[2-(3-Benzyloxycarbonyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl- butyric acid benzyl ester 5 Ib-57 Phosphoric acid mono- {1,1 -dimethyl-3-[2-(3 -methyl-3-phosphonooxy-butane- 1 -sulfinyl)-ethanesulfmyl] - propyl} ester 10 Ib-58 5-[3-(4-Hydroxy-4-methyl-pentane-l-sulfmyl)-propane-l-sulfinyl]-2-methyl-pentan-2-ol Ib-59 5-[3-(5-Hydroxy-4,4-dimethyl-pentane-l-sulfinyl)-propane-l-sulfmyl]-2,2-dimethyl-pentan- 25 l-ol 30 Ib-60 5-[3-(4-Carboxy-4-methyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-2,2-dimethyl- pentanoic acid 35 Ib-61 5-[3-(4,4-Dimethyl-5-oxo-pentane-l-sulfinyl)-propane-l-sulfmyl]-2,2-dimethyl-pentanal Ib-62 _[3-(4_Methoxycarbonyl-4-methyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-2,2-dimethyl- pentanoic acid methyl ester Ib-63 ,3-Dimethyl-6-[3-(4-methyl-4-phenoxycarbonyl-pentane-l-sulfinyl)-propane-l-sulfmyl]- hexanoic acid phenyl ester Ib-64 -[3-(4-Benzyloxycarbonyl-4-methyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-3,3-dimethyl- hexanoic acid benzyl ester Ib-65 2-Methyl-5 -[3 -(4-methyl-4-sulfo-pentane- 1 -sulfinyl)-propane-l -sulfinyl]-pentane-2- sulfonic acid Ib-66 Phosphoric acid mono- {1,1 -dimethyl-4-[3-(4-methyl-4-phosphonooxy-pentane- 1 -sulfinyl)-propane- 1 - sulfinyl]-butyl} ester Ib-67 -{l,l-Dimethyl-4-[3-(4-methyl-4-{3,3a-dihydro-2H-thieno[3,2-c]-4,6-dioxo-ρyridine-5-yl} -pentane-l-sulfmyl)-propane-l-sulfinyl]-butyl}-3,3a-dihydro-2H-thie no [3 ,2-c]pyridine-4,6-dione Ib-68 - { 1 , 1 -Dimethyl-4-[3-(4-methyl-4- {3,3a-dihydro-2H-thieno[3,2-c]-4,6-dithioxo-pyridine-5- yl} -pentane- 1 -sulfinyl)-propane- 1 -sulfinyl] -butyl} -3 ,3 a-dihydro-2H-thie no[3,2-c]pyridine-4,6-dithione Ib-69 -[3-(4-Cyanocarbamoyl-4-methyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-2,2-dimethyl-pe ntanoic acid cyanamide Ib-70 Phosphoramidic acid mono-(4-{3-[4-(amino-hydroxy-phosphoryloxy)-4-methyl-pentane-l-sulfinyl]- propane- 1 -sulfinyl} -1,1 -dimethyl-butyl) ester Ib-71 -(Amino-hydroxy-phosρhoryloxy)-4-methyl-l-[3-(4-{amino-hydroxy-phosphoryloxy}-4-m ethyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl]-pentane Ib-72 -(l , 1 -Dimethyl-4- {3-[4-methyl-4-(3H-[ 1 ,2,3]triazol- 1 -yl)-pentane- 1 -sulfinyl]-propane- 1 - sulfinyl}-butyl)-lH-tetrazole Ib-73 -(l,l-Dimethyl-4-{3-[4-methyl-4-(3H-[l,2,3]triazol-4-yl)-pentane-l-sulfmyl]-propane-l- sulfmyl} -butyl)- 1 H-tetrazole Ib-74 -{l,l-Dimethyl-4-[3-(4-{isoxazol-3-ol-5-yl}-4-methyl-pentane-l-sulfmyl)-propane-l-sulfi nyl]-butyl} -isoxazol-3-ol Ib-75 - { 1 , 1 -Dimethyl-4-[3 -(4- {isoxazol-3 -ol-4-yl} -4-methyl-pentane- 1 -sulfinyl)-propane- 1 -sulfi nyl]-butyl}-isoxazol-3-ol Ib-76 - { 1 , 1 -Dimethyl-4-[3-(4- {5-hydroxy-4-oxo-pyran-3-yl} -4-methyl-pentane-l -sulfinyl)-propa ne-l-sulfinyl]-butyl}-5-hydroxy-pyran-4-one Ib-77 - { 1 , 1 -Dimethyl-4-[3-(4- {5-hydroxy-4-oxo-pyran-2-yl} -4-methyl-pentane- 1 -sulfinyl)-propa ne- 1 -sulfinyl] -butyl} -5 -hydroxy-pyran-4-one Ib-78 - { 1 , 1 -Dimethyl-4-[3-(4- { 1 -ethyl-2,4-dioxo-imidazolidine-3-yl} -4-methyl-pentane-l -sulfin yl)-propane- 1 -sulfinyl] -butyl} - 1 -ethyl-imidazolidine- 2,4-dione Ib-79 - { 1 , 1 -Dimethyl-4-[3-(4- { 1 -ethyl-2,4-dithioxo-imidazohdine-3-yl} -4-methyl-pentane- 1-sulf inyl)-propane- 1 -sulfinyl]-butyl} - 1 -ethyl-imidazolidine- 2,4-dithione Ib-80 3- { 1 , 1 -Dimethyl-4-[3-(4- { 1 -ethyl-2-thixoxo- -oxo-imidazolidine-3-yl}-4-methyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-butyl}-l-ethyl- imidazolidine-2-thione-4-one Ib-81 3-{l,l-Dimethyl-4-[3-(4-{l-ethyl-2-one-4- thioxo-imidazolidine-3-yl} -4-methyl-pentane- 1 -sulfinyl)-propane- 1 -sulfmyl]-butyl} - 1 -ethyl -imidazolidine-2-one-4-thione Ib-82 5 - [2-(4-Carboxy-3 ,3 -dimethyl-butane- 1 -sulfinyl)-ethanesulfmyl] -3,3 -dimethyl- pentanoic acid Ib-83 5-[2-(3,3-Dimethyl-5-oxo-pentane-l-sulfinyl)-ethanesulfmyl]-3,3-dimethyl-pentanal Ib-84 -[2-(4-Methoxycarbonyl-3,3-dimethyl-butane-l-sulfmyl)-ethanesulfinyl]-3,3-dimethyl- pentanoic acid methyl ester Ib-85 -[2-(3,3-Dimethyl-4-phenoxycarbonyl-butane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl- pentanoic acid phenyl ester Ib-86 -[2-(4-Benzyloxycarbonyl-3 ,3 -dimethyl-butane- 1 -sulfinyl)-ethanesulfinyl]-3 ,3-dimethyl- pentanoic acid benzyl ester Ib-87 4-[2-(3,3-Dimethyl-4-sulfo-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl- butane-1-sulfonic acid Ib-88 Phosphoric acid mono-{4-[2-(3,3-dimethyl-4-phosphonooxy -butane-1 -sulfmyl)-ethanesulfinyl]-2,2-dimethyl-butyl} ester Ib-89 -{4-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridine-5-yl}-butane-l- sulfinyl)-ethanesulfmyl]-2,2-dimethyl-butyl}-3,3a-dihydro-2H-thien o[3,2-c]pyridine-4,6-dione Ib-90 -{4-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]ρyridine-5-yl}-butane - 1 -sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl} -3 ,3 a-dihydro-2H-thien o[3,2-c]pyridine-4,6-dithione Ib-91 -[2-(4-Cyanocarbamoyl-3,3-dimethyl-butane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pent anoic acid cyanamide Ib-92 Phosphoramidic acid mono-(4- {2-[4-(amino-hydroxy-phosphoryloxy)-3,3- dimethyl-butane-l-sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl) ester Ib-93 l-[2-(3,3-Dimethyl-4{amino-hydroxy-phosphoryloxy}-butane-l-sulfinyl)-ethanesulfmyl]-3, 3-dimethyl-4 {amino-hydroxy-phosphoryloxy} -butane Ib-94 5-{4-[2-(3,3-Dimethyl-4-tetrazol-5-yl-butane-l-sulfmyl)-ethanesulfmyl]-2,2-dimethyl- butyl} - 1 H-tetrazole Ib-95 5- {4-[2-(3,3-Dimethyl-4-tetrazol-l -yl-butane-1 -sulfmyl)-ethanesulfmyl]-2,2-dimethyl- butyl} - 1 H-tetrazole Ib-96 -{4-[2-(3,3-Dimethyl-4-isoxazol-3-ol-5-yl-butane-l-sulfinyl)-ethanesulfmyl]-2,2-dimethyl- butyl } -isoxazol-3 -ol Ib-97 4-{4-[2-(3,3-Dimethyl-4-isoxazol-3-ol-4-yl-butane-l-sulfmyl)-ethanesulfinyl]-2,2- dimethyl-butyl} -isoxazol-3 -ol Ib-98 - {4- [2-(3 ,3 -Dimethyl-4- { 5 -hydroxy-4-oxy-pyran-3 -yl} -butane- 1 -sulfinyl)-ethanesulfinyl]-2 ,2-dimethyl-butyl}-5-hydroxy-pyran-4-one Ib-99 -{4-[2-(3,3-Dimethyl-4-{5-hydroxy-4-oxy-pyran-3-yl}-butane-l-sulfmyl)-ethanesulfinyl]-2 ,2-dimethyl-butyl}-5-hydroxy-pyran-4-one Ib-100 -{4-[2-(3,3-Dimethyl-4-{5-hydroxy-4-oxy-pyran-2-yl}-butane-l-sulfmyl)-ethanesulfinyl]-2 ,2-dimethyl-butyl}-5-hydroxy-pyran-4-one Ib-101 -{4-[2-(3,3-Dimethyl-4-{l-Ethyl-2,4-dithioxo-imidazolidine-3-yl}-butane-l-sulfinyl)-etha nesulfinyl]-2,2-dimethyl-butyl}-l-ethyl-imidazolidine-2,4-dithione Ib-102 l-Ethyl-3-(4-{2-[4-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l-sulfmyl] -ethanesulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione Ib-103 l-Ethyl-3-(4-{2-[4-(3-ethyl-2,5-dioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l-sulfmyl]- ethanesulfmyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione Ib-104 l-Ethyl-3-(4-{2-[4-(3-ethyl-2-thioxo-5-oxo-imidazolidin-l-yl)-3,3- dimethyl-butane- 1 -sulfinyl] -ethanesulfinyl} -2,2-dimethyl-butyl)-imidazolidine-2-thione- 4-one Ib-105 l-Ethyl-3-(4-{2-[4-(3-ethyl-2-oxo-5-thioxo-imidazolidin-l-yl)-3,3- dimethyl- butane- 1 -sulfinyl]-ethanesulfinyl} -2,2-dimethyl-butyl)-imidazolidine-2-one-4-thione Ib-106 - [2-(6-Hydroxy-3 ,3 -dimethyl-hexane- 1 -sulfinyl)-ethanesulfinyl] -4,4-dimethyl-hexan- 1 -ol Ib-107 -[2-(5-Carboxy-3,3-dimethyl-pentane-l-sulfinyl)-ethanesulfinyl]-4,4-dimethyl-hexanoic acid Ib-108 6-[2-(3,3-Dimethyl-6-oxo-hexane-l-sulfmyl)-ethanesulfmyl]-4,4-dimethyl-hexanal Ib-109 -[2-(5-Methoxycarbonyl-3,3-dimethyl-pentane-l-sulfmyl)-ethanesulfinyl]-4,4-dimethyl- hexanoic acid methyl ester Ib-110 -[2-(3,3-Dimethyl-5-phenoxycarbonyl-pentane-l-sulfinyl)-ethanesulfinyl]-4,4-dimethyl- hexanoic acid phenyl ester Ib-111 -[2-(5-Benzyloxycarbonyl-3,3-dimethyl-pentane-l-sulfinyl)-ethanesulfmyl]-4,4-dimethyl- hexanoic acid benzyl ester Ib-112 5 -[2-(3 ,3 -Dimethyl-5 -sulfo-pentane- 1 -sulfinyl)-ethanesulfinyl]-3 ,3-dimethyl-pentane- 1 - sulfonic acid Ib-113 Phosphoric acid mono-{5-[2-(3,3-dimethyl-5-phosphonooxy-pentane-l- ulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentyl} ester Ib-114 -{5-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl}-pentane-l- sulfinyl)-ethanesulfinyl]-3 ,3 -dimethyl-pentyl} -3 ,3 a-dihydro-2H-thieno [3 ,2-c] pyridine-4,6-dione Ib-115 -{5-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-pentane -l-sulfmyl)-ethanesulfinyl]-3,3-dimethyl-pentyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine- 4,6-dithione Ib-116 6-[2-(5-Cyanocarbamoyl-3,3-dimethyl-pentane-l-sulfinyl)-ethanesulfinyl]-4,4-dimethyl- hexanoic acid cyanimide Ib-117 Phosphoramidic acid mono-(5-{2-[5-(amino-hydroxy-phosphoryloxy)-3,3-dimethyl-pentane-l-sulfinyl]- ethanesulfinyl}-3,3-dimethyl-pentyl) ester Ib-118 l-[2-(3,3-Dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane-l-sulfinyl)-ethanesulfinyl]- 3,3-dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane Ib-119 -[2-(4-Hydroxy-3,3-dimethyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butan-l-ol Ib-120 4-[2-(3-Carboxy-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid Ib-121 4-[2-(3,3-Dimethyl-4-oxo-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyraldehyde Ib-122 -[2-(3-Methoxycarbonyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid methyl ester Ib-123 2,2-Dimethyl-4-[2-(3-methyl-3-phenoxycarbonyl-butane-l-sulfinyl)-ethanesulfinyl]- butyric acid phenyl ester Ib-124 4-[2-(3-Benzyloxycarbonyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyri c acid benzyl ester Ib-125 2-Methyl-4-[2-(3-methyl-3-sulfo-butane-l-sulfmyl)-ethanesulfmyl]-butane-2-sulfonic acid Ib-126 Phosphoric acid mono-{l,l-dimethyl-3-[2-(3-methyl-3-phosphonooxy-butane-l- ulfmyl)-ethanesulfinyl]-propyl} ester Ib-127 5-{l,l-Dimethyl-3-[2-(3-methyl-3-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridine-5-yl}- butane-l-sulfinyl)-ethanesulfinyl]-propyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione Ib-128 -{l,l-Dimethyl-3-[2-(3-methyl-3-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridine-5-y l}-butane-l-sulfmyl)-ethanesulfinyl]-propyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6- ithione Ib-129 4-[2-(3-Cyanocarbamoyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl- butyrcyanimide Ib-130 Phosphoramidic acid mono-(3- {2-[3-(amino-hydroxy-ρhosphoryloxy)-3-methyl-butane-l- ulfinyl] -ethanesulfinyl} - 1 , 1 -dimethyl-propyl) ester Ib-131 -[2-(3 ,3-Dimethyl-4- {amino-hydroxy-phosphoryloxy} -butane- 1 -sulfinyl)-ethanesulfinyl]-3 ,3 -dimethyl-4- {amino-hydroxy-phosphoryloxy} -butane Ib-132 l-{5-[2-(3,3-Dimethyl-5-{tetrazol-l-yl}-pentane-l-sulfinyl)-ethylsulfanyl]-3,3-dimethyl-pe ntyl}-lH-tetrazole Ib-133 5-{5-[2-(3,3-Dimethyl-5-{tetrazol-5-yl}-pentane-l-sulfinyl)-ethylsulfanyl]-3,3-dimethyl-pe ntyl}-lH-tetrazole Ib-134 5-{5-[2-(3,3-Dimethyl-5-(isoxazol-3-ol-5-yl}-pentane-l-sulfmyl)-ethanesulfinyl]-3,3- imethyl-pentyl} -isoxazol-3 -ol Ib-135 4- {5 - [2-(3 ,3 -Dimethyl-5 -(isoxazol-3 -ol-4-yl} -pentane- 1 -sulfinyl)-ethanesulfmyl] -3,3- imethyl-pentyl} -isoxazol-3 -ol Ib-136 2-{5-[2-(3,3-Dimethyl-5-{5-Hydroxy~4-oxy-ρyran-3-yl}- pentane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentyl}-5-hydroxy-pyran-4-one Ib-137 2-{5-[2-(3,3-Dimethyl-5-{5-Hydroxy~4-oxy-pyran-2-yl}-pentane-l-sulfmyl)- thanesulfinyl]-3,3-dimethyl-pentyl}-5-hydroxy-pyran-4-one Ib-138 3-{5-[2-(3,3-Dimethyl-5-{5-Hydroxy-4-oxy-pyran-3-yl}- pentane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentyl}-5-hydroxy-pyran-4-one Ib-139 l-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-pentane-l- ulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dione Ib-140 l-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dioxo-imidazolidin-l-yl)-3,3-dimethyl-pentane-l-sulfinyl]-e thanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dione Ib-141 l-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-pentane-l- ulfinyl]-ethanesulfmyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dithione Ib-142 l-Ethyl-3-(5-{2-[5-(3-ethyl-2-thioxo-5-oxo-imidazolidin-l-yl)-3,3-dimethyl-pentane-l- ulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2-thione-4-one Ib-143 l-Ethyl-3-(5-{2-[5-(3-ethyl-2-oxo-5-thioxo-imidazolidin-l-yl)-3,3-dimethyl- ρentane-1-sulfinyl]- ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2-one-4-thione Ib-144 6- [3 -(5 -Carboxy-4,4-dimethyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl] -3 ,3 -dimethyl- hexanoic acid Ib-145 6-[3-(4,4-Dimethyl-6-oxo-hexane-l-sulfinyl)-propane-l-sulfinyl]-3,3-dimethyl-hexanal Ib-146 -[3-(5-Methoxycarbonyl-4,4-dimethyl-pentane-l-sulfmyl)-propane-l-sulfmyl]-3,3-dimethy 1-hexanoic acid methyl ester Ib-147 6-[3-(6-Hydroxy-4,4-dimethyl-hexane-l-sulfinyl)-propane-l-sulfinyl]-3,3-dimethyl- hexan-1-ol Ib-148 -[3-(4,4-Dimethyl-5-phenoxycarbonyl-pentane-l-sulfinyl)-propane-l-sulfmyl]-3,3-dimethy 1-hexanoic acid phenyl ester Ib-149 -[3-(5-Benzyloxycarbonyl-4,4-dimethyl-pentane-l-sulfmyl)-propane-l-sulfmyl]-3,3-dimet hyl-hexanoic acid benzyl ester Ib-150 -(3-{2-[3-(3-Ethyl-2,6-dioxo-3,6-dihydro-2H-pyridin-l-yl)-3-methyl-butane-l-sulfmyl]-eth anesulfinyl} -1,1 -dimethyl-propyl)-3 ,3 a-dihydro-2H-thieno[3 ,2-c]pyridine-4,6-dione Ib-151 -(3 ,3 a-Dihydro-2H-thieno[3 ,2-c]pyridine-4,6-dithione)-3-methyl- 1 -[2-(3 - {3 ,3 a-Dihydro-2 H-thieno[3 ,2-c]pyridine-4,6-dithione} -3 -methyl-butane- 1 -sulfinyl)-ethanesulfinyl]- butane Ib-152 -[2-(3-Cyanocarbamoyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-cyanobu tyramide Ib-153 Phosphoramidic acid mono-(3-{2-[3-(amino-hydroxy-phosphoryloxy)-3-methyl-butane-l-sulfmyl]-ethanesu lfinyl} -1,1 -dimethyl-propyl) ester Ib-154 -(Amino-hydroxy-phosphoryloxy)-3-methyl-l-[2-(3-{amino-hyroxy-phosphoyloxy}-3-met hyl-butane-l-sulfinyl)-ethanesulfinyl]-butane Ib-155 -Methyl-3-tetrazol- 1 -yl- 1 -[2-(3 -methyl-3 -tetrazol- 1 -yl-butane- 1 -sulfinyl)-ethanesulfinyl]-b utane Ib-156 3-Methyl-3-lH-tetrazol-5-yl-l-[2-(3-methyl-3-lH- tetrazol-5 -yl-butane- 1 -sulfinyl)-ethanesulfinyl] -butane Ib-157 -[3-(4,4-Dimethyl-5-sulfo-pentane-l-sulfmyl)-propane-l-sulfinyl]-2,2-dimethyl-pentane-l- sulfonic acid Ib-158 Phosphoric acid mono-{5-[3-(4,4-dimethyl-5-ρhosphonooxy-pentane-l-sulfinyl)-ρroρane-l-sulfinyl]-2,2- dimethyl-pentyl} ester Ib-159 l-[3-(5-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dione}-4,4-Dimethyl-pentane-l-sulfiny l)-propane-l-sulfinyl]-5-(3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dione)-4,4-dimethyl-p entane Ib-160 l-[3-(5-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-4,4-Dimethyl-pentane-l-sulf inyl)-propane-l-sulfinyl]-5-(3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione)-4,4-dimet hyl-pentane Ib-161 6-[3-(5-Cyanocarbamoyl-4,4-dimethyl-pentane-l-sulfmyl)-propane-l-sulfinyl]-3,3- dimethyl-hexanoic acid cyanamide Ib-162 Phosphoramidic acid mono-[16-(amino-hydroxy-phosphoryloxy)-4,4,15,15-tetramethyl- 7,11 -dioxo-hexadecyl] ester Ib-163 -[3-(4,4-Dimethyl-5- {amino-hydroxy-phosphoryloxy} -pentane- 1 -sulfinyl)-propane- 1 -sulfi nyl]-4,4-dimethyl-5-(amino-hydroxy-phosphoryloxy)-pentane Ib-164 ,4-Dimethyl-5-tetrazol-l -yl- 1 -[3-(4,4-dimethyl-5-tetrazol-l -yl-pentane- 1 -sulfmyl)-propane -l-sulfmyl]-ρentane Ib-165 4,4-Dimethyl-5-lH-tetrazol-5-yl-l-[3-(4,4-dimethyl-5-lH- tetrazol-5-yl-pentane-l-sulfmyl)-propane-l-sulfinyl]-pentane Ib-166 l-[3-(5-isoxazol-5-yl-4,4-dimethyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-5-isoxazol-5-yl- 4,4-dimethyl-hexane Ib-167 l-[3-(5-isoxazol-4-yl-4,4-dimethyl-pentane-l-sulfmyl)-propane-l-sulfinyl]-5-isoxazol-4-yl- 4,4-dimethyl-hexane Ib-168 l-[3-(5-{5- Ηydroxy-4-oxo-4Η-pyran-3-yl}-4,4-dimethyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-5-(5-h ydroxy-4-oxo-4H-pyran-2-yl)-4,4-dimethyl-pentane Ib-169 l-[3-(5-{5- Hydroxy-4-oxo-4H-pyran-2-yl}-4,4-dimethyl-pentane-l-sulfmyl)-propane-l-sulfinyl]-5-(5-h ydroxy-4-oxo-4H-pyran-2-yl)-4,4-dimethyl-pentane Ib-170 l-[3-(5-{5- Hydroxy-4-oxo-4H-pyran-3-yl}-4,4-dimethyl-pentane-l-sulfinyl)-propane-l-sulfmyl]-5-(5-h ydroxy-4-oxo-4H-pyran-3-yl)-4,4-dimethyl-pentane Ib-171 l-[3-(5-{l-ethyl-2,4- dithioxo-imidazolidinyl}-4,4-dimethyl-pentane-l-sulfmyl)-propane-l-sulfinyl]-5-(l-ethyl-2, 4-dithioxo-imidazolidinyl)-4,4-dimethyl-pentane Ib-172 l-[3-(5-{l-ethyl-2,4- dithioxo-imidazolidinyl} -4,4-dimethyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl]-5-( 1 -ethyl-2, 4-dioxo-imidazolidinyl)-4,4-dimethyl-pentane Ib-173 l-[3-(5-{l-ethyl-2,4- dioxo-imidazolidinyl}-4,4-dimethyl-pentane-l-sulfmyl)-propane-l-sulfinyl]-5-(l-ethyl-2,4- dioxo-imidazolidinyl)-4,4-dimethyl-pentane Ib-174 l-[3-(5-{l-ethyl-2-thioxo-imidazolidin-4-one}-4,4-dimethyl-pentane-l-sulfinyl)-propane-l- sulfmyl]-4-(l-ethyl-2-thioxo-imidazolidin-4-one)-4,4-dimethyl-pentane Ib-175 -[3 -(5- { 1 -ethyl-4-thioxo-imidazolidin-2-one} -4,4-dimethyl-pentane- 1 -sulfmyl)-propane- 1 - sulfmyl]-5-(l-ethyl-4-thioxo-imidazolidin-2-one)-4,4-dimethyl-pentane Ib-176 -[2-(5-Hydroxy-3,3-dimethyl-pentane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentan-l-ol Ic-1 -[2-(3-Tetrahydro-pyran-2-oxy-ethanesulfinyl-propane-l-sulfinyl)-ethoxy]-tetrahydro- pyran Ic-2 4-[2-(3-2-{2-oxyoxetan-4-yl}-ethanesulfinyl-propane-l-sulfinyl)-ethyl]-oxetan-2-one Ic-3 3-[2-(3-2- {2-oxyoxetan-3-yl} -ethanesulfmyl-propane-l -sulfinyl)-ethyl]-oxetan-2-one Ic-4 5-[2-(3-2-{2-oxo-dihydro-furan-5-yl}-ethanesulfinyl-propane-l-sulfinyl)-ethyl]- dihydro-furan-2-one Ic-5 4-[2-(3-2-{2-oxo-dihydro-furan-4-yl}-ethanesulfinyl-propane-l-sulfinyl)-ethyl]- dihydro-furan-2-one Ic-6 3-[2-(3-2-{2-oxo-dihydro-furan-3-yl}-ethanesulfinyl-propane-l-sulfinyl)-ethyl]- dihydro-furan-2-one Ic-7 [2-(2-{3-[2-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethanesulfinyl]- propane- 1 -sulfinyl} -ethyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl]-acetic acid Ic-8 6-[2-(3-2- {2-oxo-tetrahydro-pyran-6-yl} -Ethanesulfinyl-propane- 1 -sulfinyl)-ethyl]- tetrahydro-pyran-2-one Ic-9 5-[2-(3-2-{2-oxo-tetrahydro-pyran-5-yl}-Ethanesulfinyl-propane-l-sulfinyl)-ethyl]- texrahydro-pyran-2-one Ic-10 -[2-(3-2-{2-oxo-tetrahydro-pyran-4-yl}-Ethanesulfinyl-propane-l-sulfinyl)-ethyl]- tetrahydro-pyran-2-one Ic-11 -[2-(3-2-{2-oxo-tetrahydro-pyran-3-yl}-Ethanesulfinyl-propane-l-sulfinyl)-ethyl]- tetrahydro-pyran-2-one Ic-12 2-[3-(3-Tetrahydro-pyran-2-oxy-propanesulfinyl-propane-l-sulfinyl)-ethoxy]- tetrahydro-pyran Ic-13 4-{3-[3-(3-{2-oxo-oxetan-4-yl}-propane-l-sulfinyl)-propane-l-sulfinyl]-propyl}- oxetan-2-one Ic-14 -{3-[3-(3- {2-oxo-oxetan-3 -yl} -propane- 1 -sulfinyl)-prop ane- 1 -sulfinyl] -propyl} - oxetan-2-one Ic-15 5-{3-[3-(3-{2-oxo-dihydro-furan-5-yl}-propane-l- sulfinyl)-propane-l- sulfinyl]-propyl}-dihydrofuran-2-one Ic-16 4- {3-[3-(3- {2-oxo-dihydro-furan-4-yl} -propane- 1 -sulfinyl)-propane- 1 - sulfinyl]-propyl}-dihydrofuran-2-one Ic-17 3- {3-[3-(3- {2-oxo-dihydro-furan-3-yl} -propane- 1 -sulfinyl)-propane- 1 - sulfinyl]-propyl}-dihydrofuran-2-one Ic-18 [2-(3-{3-[3-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-propane-l-sulfinyl]- propane- 1 -sulfinyl} -propyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl]-acetic acid Ic-19 6-{3-[3-(3-{2-oxo-tetrahydro-pyran-6-yl}-propane-l-sulfmyl)-propane-l-sulfinyl]- propyl} -tetrahydro-pyran-2-one Ic-20 5-{3-[3-(3-{2-oxo-tetrahydro-pyran-5-yl}-propane-l-sulfinyl)-propane-l-sulfinyl]- propyl} -tetrahydro-pyran-2-one Ic-21 4- {3-[3-(3- {2-oxo-tetrahydro-pyran-4-yl} -propane- 1 -sulfrnyl)-propane- 1 -sulfinyl]- propyl} -tetrahydro-pyran-2-one Ic-22 3-{3-[3-(3-{2-oxo-tetrahyά o-pyran-3-yl}-propane-l-sulfinyl)-propane-l-sulfinyl]- propyl} -tetrahydro-pyran-2-one Ic-24 -[2-(3-Tetrahydro-pyran-2-oxy-ethanesulfinyl-ethane-l-sulfinyl)-ethoxy]-tetrahydro-pyran Ic-25 4-[2-(2-{2-oxo-oxetan-4-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-oxetan-2-one Ic-26 3-[2-(2-{2-oxo-oxetan-3-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-oxetan-2-one Ic-27 5-[2-(2-{2-oxo-dihydro-furan-5-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-dihydro- furan-2-one Ic-28 4-[2-(2-{2-oxo-dihydro-furan-4-yl}-ethanesulfmyl-ethanesulfinyl)-ethyl]-dihydro- furan-2-one Ic-29 3-[2-(2-{2-oxo-dihydro-furan-3-yl}-ethanesulfmyl-ethanesulfinyl)-ethyl]-dihydro- furan-2-one Ic-30 [2-(2-{2-[2-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethanesulfinyl]- ethanesulfinyl} -ethyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl] -acetic acid Ic-31 -[2-(3-2-{2-oxo-tetrahydro-pyran-6-yl}-ethanesulfinyl-ethane-l-sulfinyl)-ethyl]- tetrahydro-pyran-2-one Ic-32 -[2-(3-2-{2-oxo-tetrahydro-pyran-5-yl}-ethanesulfmyl-ethane-l-sulfinyl)-ethyl]- tetrahydro-pyran-2-one Ic-33 -[2-(3-2-{2-oxo-tetrahydro-pyran-4-yl}-ethanesulfinyl-ethane-l-sulfmyl)-ethyl]- tetrahydro-pyran-2-one Ic-34 -[2-(3-2-{2-oxo-tetrahydro-pyran-3-yl}-ethanesulfinyl-ethane-l-sulfinyl)-ethyl]- tetrahydro-pyran-2-one II-l 6-(6-Hydroxy-5,5-dimethyl-hexane-l-sulfinyl)-2,2-dimethyl-hexan-l-ol HOOC" "S' "COOH II 0 II-2 6-(5-Carboxy-5-methyl-hexane-l-sulfinyl)-2,2-dimethyl-hexanoic acid HOOC. COOH π-3 -(5-Hydroperoxy-4,4-dimethyl-pentane-l-sulfinyl)-2,2-dimethyl-pentanoic acid HOH 2 C. CH 2 OH π-4 5-(5-Hydroxy-4,4-dimethyl-pentane-l-sulfinyl)-2,2-dimethyl-pentan-l-ol HOH 2 C COOH 5-(5-Hydroxy-4,4-dimethyl-pentane-l-sulfmyl)-2,2-dimethyl-pentanoic acid HOOC COOH II-6 5-(4-Carboxy-4-methyl-pentane-l-sulfinyl)-2,2-dimethyl-pentanoic acid II-7 7-(7-Hydroxy-6,6-dimethyl-heptane- 1 -sulfmyl)-2,2-dimethyl-heptan- 1 -ol II-8 -(7-Hydroxy-6,6-dimethyl-heptane- 1 -sulfinyl)-2,2-dimethyl-heptanoic acid II-9 7-(6-Carboxy-6-methyl-heptane- 1 -sulfinyl)-2,2-dimethyl-heptanoic acid OHC -S' II CHO O 11-10 6-(5 , 5 -Dimethyl-6-oxo-hexane- 1 -sulfinyl)-2,2-dimethyl-hexanal H 3 COOC "S' 11 "COOCH 3 O 11-11 6-(5-Methoxycarbonyl-5-methyl-hexane-l-sulfinyl)-2,2-dimethyl-hexanoic acid methyl ester π-12 -(5 ,5-Dimethyl-6-oxo-6-phenyl-hexane- 1 -sulfinyl)-2,2-dimethyl- 1 -phenyl-hexan- 1 -one -(5,5-Dimethyl-6-oxo-7-phenyl-heptane-l-sulfinyl)-3,3-dimethyl-l-phenyl-heptan-2-one π-14 2-Methyl-6-(5-methyl-5-sulfo-hexane- 1 -sulfinyl)-hexane-2-sulfonic acid 11-15 Phosphoric acid mono- [l,l-dimethyl-5-(5-methyl-5- phosphonooxy-hexane- 1 -sulfinyl)-pentyl] ester π-16 7-(6,6-Dimethyl-7-oxo-heptane-l-sulfinyl)-2,2-dimethyl-heptanal OOCH 3 TCOOCH 3 o 11-17 -(6-Methoxycarbonyl-6-methyl-heptane-l-sulfmyl)-2,2-dimethyl-heptanoic acid methyl ester 11-18 -(6,6-Dimethyl-7-oxo-7-phenyl-heptane-l-sulfmyl)-2,2-dimethyl-l-phenyl-heptan-l-one 11-19 8-(6,6-Dimethyl-7-oxo-8-phenyl-octane-l-sulfmyl)-3,3-dimethyl-l-phenyl-octan-2-one π-20 2-Methyl-7-(6-methyl-6-sulfo-heptane-l-sulfinyl)-heptane-2-sulfonic acid 11-21 Phosphoric acid mono-[l,l-dimethyl-6- (6-methyl-6-phosphonooxy-heptane- 1 -sulfinyl)-hexyl] ester II-22 7-(7-Hydroxy-5,5-dimethyl-heptane-l-sulfinyl)-3,3-dimethyl-heptan-l-ol 11-23 -(7-Hydroxy-5,5-dimethyl-heptane-l-sulfinyl)-3,3-dimethyl-heptanoic acid 11-24 -(6-Carboxy-5 ,5 -dimethyl-hexane- 1 -sulfinyl)-3 ,3 -dimethyl-heptanoic acid 6-(6-Hydroxy-4,4-dimethyl-hexane- 1 -sulfinyl)-3 ,3-dimethyl-hexan- 1 -ol HOH 2 C "S' ;OOH II O 11-26 -(6-Hydroxy-4,4-dimethyl-hexane-l-sulfinyl)-3,3-dimethyl-hexanoic acid HOOC "S' OOH II O π-27 -(5-Carboxy-4,4-dimethyl-pentane-l-sulfinyl)-3,3-dimethyl-hexanoic acid 11-28 8-(8-Hydroxy-6,6-dimethyl-octane- 1 -sulfinyl)-3 ,3-dimethyl-octan- 1 -ol π-29 -(8-Hydroxy-6,6-dimethyl-octane-l-sulfinyl)-3,3-dimethyl-octanoic acid 11-30 -(7-Carboxy-6,6-dimethyl-heptane- 1 -sulfinyl)-3 ,3-dimethyl-octanoic acid 11-31 8-(8-Hydroxy-5 ,5 -dimethyl-octane- 1 -sulfinyl)-4,4-dimethyl-octan-l -ol 11-32 8-(8-Hydroxy-5,5-dimethyl-octane-l-sulfinyl)-4,4-dimethyl-octanoic acid 11-33 -(7-Carboxy-5,5-dimethyl-heptane-l-sulfmyl)-4,4-dimethyl-octanoic acid π-34 7-(7-Hydroxy-4,4-dimethyl-heptane- 1 -sulfinyl)-4,4-dimethyl-heptan- 1 -ol 11-35 -(7-Hydroxy-4,4-dimethyl-heptane- 1 -sulfinyl)-4,4-dimethyl-heptanoic acid π-36 7-(6-Carboxy-4,4-dimethyl-hexane- 1 -sulfinyl)-4,4-dimethyl-heρtanoic acid 11-37 9-(9-Hydroxy-6,6-dimethyl-nonane- 1 -sulfinyl)-4,4-dimethyl-nonan- 1 -ol 11-38 9-(9-Hydroxy-6,6-dimethyl-nonane- 1 -sulfinyl)-4,4-dimethyl-nonanoic acid π-39 9-(8-Carboxy-6,6-dimethyl-octane-l-sulfinyl)-4,4-dimethyl-nonanoic acid π-40 -[l,l-Dimethyl-4-(4-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl}-4-methyl-ρent ane- 1 -sulfmyl)-butyl]-3 ,3 a-dihydro-2H-thieno [3 ,2-c]pyridine-4,6-dione 11-41 -[l,l-Dimethyl-4-(4-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-4-methyl-p entane-l-sulfmyl)-butyl]-3,3a-dihydro-2H-triieno[3,2-c]pyridine-4,6-dithione 11-42 -(4-Cyanocarbamoyl-4-methyl-pentane-l-sulfinyl)-2,2-dimethyl-pentanoic acid cyanimide 11-43 Phosphoramidic acid mono-{4-[4-(amino-hydroxy-phosphoryloxy)- 4-methyl-ρentane- 1 -sulfinyl]- 1 , 1 -dimethyl-butyl} ester π-44 -(Amino-hydroxy-phosphoryloxy)-4-methyl-l-(4-[amino-hydroxy-phosphoryloxy]-4-meth yl-pentane- 1 -sulfinyl)-pentane 11-45 5-[l,l-Dimethyl-5-(5-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl}-5- methyl-hexane-l-sulfmyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione π-46 5-[l,l-Dimethyl-5-(5-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-5- methyl-hexane-l-sulfinyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione π-47 6-(5-Cyanocarbamoyl-5-methyl-hexylsulfanyl)-2,2-dimethyl-hexanoic acid cyanimide 11-48 Phosphoramidic acid mono-{5-[5-(amino-hydroxy-phosphoryloxy)- 5 -methyl-hexane- 1 -sulfinyl] -1,1 -dimethyl-pentyl} ester π-49 -(Amino-hydroxy-phosphoryloxy)-5-methyl-l-([5-amino-hydroxy-phosphoryloxy]-5-meth yl-hexane-1 -sulfmyl)-hexane π-50 1 -[ 1 , 1 -Dimethyl-5-(5-methyl-5-tetrazol-l -yl-hexane-1 -sulfinyl)-pentyl]-lH-tetrazole II-51 5-[l,l-Dimethyl-5-(5-methyl-5-tetrazol-5-yl-hexane-l-sulfinyl)-pentyl]-lH-tetrazole -[l,l-Dimethyl-5-(5-{isoxazol-3-5-yl}-5-methyl-hexane-l-sulfinyl)-pentyl]-isoxazol-3-ol 11-53 - [ 1 , 1 -Dimethyl-5 -(5 - {isoxazol-3 -4-yl} -5 -methyl-hexane- 1 -sulfmyl)-pentyl] -isoxazol-3-ol 11-54 4-[l,l-Dimethyl-5-(5-{2-oxo-oxetan-4-yl}-5-methyl-hexane-l-sulfmyl)-pentyl]-oxetan- 2-one 11-55 3 -[ 1 , 1 -Dimethyl-5-(5 - {2-oxo-oxetan-3 -yl} -5 -methyl-hexane- 1 -sulfmyl)-pentyl] -oxetan- 2-one -[l,l-Dimethyl-5-(5-(2-oxo-dihydro-furan-5-yl}-5-methyl-hexane-l-sulfinyl)-pentyl]-dihy dro-furan-2-one 11-57 3-[l,l-Dimethyl-5-(5-(2-oxo-dihydro-furan-3-yl}-5-methyl-hexane-l-sulfinyl)-pentyl]-(lihy dro-furan-2-one 11-58 4- [ 1 , 1 -Dimethyl-5 -(5 -(2-oxo-dihydro-furan-4-yl} -5 -methyl-hexane- 1 -sulfinyl)-pentyl] -dihy dro-furan-2-one π-59 2-[l,l-Dimethyl-5-{tetrahydro-pyran-2-oxy}-5-methyl-hexane-l-sulfinyl)-pentyloxy]-tetrah ydro-pyran π-60 (2-{5-[5-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-5-methyl-hexane-l-sul finyl] -1,1 -dimethyl-pentyl} -4- hydroxy-6-oxo-tetrahydro-pyran-4-yl)-acetic acid IIa-1 7-(7-Hydroxy-6-methyl-6-phenyl-heptane- 1 -sulfinyl)-2-methyl-2-phenyl-heptan- 1 -ol IIa-2 -(7-Hydroxy-6-methyl-6-phenyl-heptane- 1 -sulfinyl)-2-methyl-2-phenyl-heptanoic acid IIa-3 7-(6-Carboxy-6-phenyl-heptane- 1 -sulfinyl)-2-methyl-2-phenyl-heptanoic acid IIa-4 6-(6-Hydroxy-5-methyl-5-phenyl-hexane-l-sulfinyl)-2-methyl-2-phenyl-hexan-l-ol IIa-5 -(6-Hydroxy-5 -methyl-5 -phenyl-hexane- 1 -sulfinyl)-2-methyl-2-phenyl-hexanoic acid IIa-6 6-(5-Carboxy-5-phenyl-hexane-l-sulfinyl)-2-methyl-2-phenyl-hexanoic acid IIa-7 5-(5-Hydroxy-4-methyl-4-phenyl-pentane-l-sulfinyl)-2-methyl-2-phenyl-pentan-l-ol IIa-8 -(5-Hydroxy-4-methyl-4-phenyl-pentane-l-sulfinyl)-2-methyl-2-phenyl-pentanoic acid Ha-9 5-(4-Carboxy-4-phenyl-pentane-l-sulfinyl)-2-methyl-2-ρhenyl-pentanoic acid IIa-10 2-Methyl-7-(6-methyl-7-oxo-6-phenyl-heptane-l-sulfinyl)-2-phenyl-heptanal IIa-11 7-(6-Methoxycarbonyl-6-phenyl-heptane-l-sulfinyl)-2-methyl-2-phenyl-heptanoic acid methyl ester IIa-12 -Methyl-7-(6-methyl-7-oxo-6,7-diphenyl-heptane- 1 -sulfinyl)- 1 ,2-diphenyl-heptan- 1 -one IIa-13 3-Methyl-8-(6-methyl-7-oxo-6,8-diphenyl-octane-l-sulfmyl)-l,3-diphenyl-octan-2-one IIa-14 2-Phenyl-7-(6-phenyl-6-sulfo-heptane- 1 -sulfmyl)-heptane-2-sulfonic acid IIa-15 Phosphoric acid mono-[l -methyl- 1- phenyl-6-(6-phenyl-6-ρhosphonooxy-heptane- 1 -sulfinyl)-hexyl] ester IIa-16 8-(8-Hydroxy-6-methyl-6-phenyl-octane-l-sulfinyl)-3-methyl-3-phenyl-octan-l-ol IIa-17 -(8-Hydroxy-6-methyl-6-phenyl-octane- 1 -sulfinyl)-3-methyl-3-phenyl-octanoic acid IIa-18 -(7-Carboxy-6-methyl-6-phenyl-heptane-l-sulfinyl)-3-methyl-3-phenyl-octanoic acid IIa-19 -(7-Hydroxy-5 -methyl-5 -phenyl-heptane- 1 -sulfinyl)-3 -methyl-3 -phenyl-heptan- 1 -ol IIa-20 -(7-Hydroxy-5-methyl-5-ρhenyl-heptane-l-sulfmyl)-3-methyl-3-phenyl-heptanoic acid IIa-21 -(6-Carboxy-5-methyl-5-phenyl-hexane- 1 -sulfinyl)-3 -methyl-3 -phenyl-heptanoic acid IIa-22 6-(6-Hydroxy-4-methyl-4-phenyl-hexane-l-sulfinyl)-3-methyl-3-phenyl-hexan-l-ol IIa-23 -(6-Hydroxy-4-methyl-4-phenyl-hexane-l-sulfinyl)-3-methyl-3-phenyl-hexanoic acid IIa-24 -(5-Carboxy-4-methyl-4-phenyl-pentane-l-sulfinyl)-3-methyl-3-phenyl-hexanoic acid IIa-25 -(6-Hydroxy-4-methyl-4-phenyl-hexane-l-sulfinyl)-3-methyl-3-phenyl-hexanoic acid IIa-26 -(5-Carboxy-4-methyl-4-phenyl-pentane-l-sulfinyl)-3-methyl-3-phenyl-hexanoic acid IIa-27 9-(9-Hydroxy-6-methyl-6-phenyl-nonane- 1 -sulfinyl)-4-methyl-4-phenyl-nonan- 1 -ol IIa-28 -(9-Hydroxy-6-methyl-6-phenyl-nonane- 1 -sulfinyl)-4-methyl-4-phenyl-nonanoic acid IIa-29 -(8-Carboxy-6-methyl-6-phenyl-octane- 1 -sulfinyl)-4-methyl-4-phenyl-nonanoic acid IIa-30 8-(8-Hydroxy-5-methyl-5-phenyl-octane-l-sulfinyl)-4-methyl-4-phenyl-octan-l-ol IIa-31 -(8-Hydroxy-5-methyl-5-phenyl-octane-l-sulfmyl)-4-methyl-4-phenyl-octanoic acid IIa-32 -(7-Carboxy-5-methyl-5-ρhenyl-heptane-l-sulfmyl)-4-methyl-4-phenyl-octanoic acid IIa-33 -(7-Hydroxy-4-methyl-4-phenyl-heptane- 1 -sulfinyl)-4-methyl-4-phenyl-heptan- 1 -ol IIa-34 7-(7-Hydroxy-4-methyl-4-phenyl-heptane- 1 -sulfinyl)-4-methyl-4-phenyl-heptanoic acid IIa-35 7-(6-Carboxy-4-methyl-4-phenyl-hexane-l-sulfmyl)-4-methyl-4-phenyl-heptanoic acid IIa-36 -[l-Methyl-l-phenyl-5-(5-phenyl-5-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl } -hexane- 1 -sulfinyl)-pentyl]-3 ,3 a-dihydro-2H-thieno[3 ,2-c]pyridine-4,6-dione IIa-37 -[l-Methyl-l-phenyl-5-(5-ρhenyl-5-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]ρyridin-5- yl}-hexane-l-sulfinyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione IIa-38 6-(5-Cyanocarbamoyl-5-phenyl-hexane-l-sulfinyl)-2-methyl-2-phenyl-hexanoic acid cyanimide IIa-39 Phosphoramidic acid mono-{5-[5- (amino- hydroxy-phosphoryloxy)-5-phenyl-hexane-l-sulfinyl]-l-methyl-l-phenyl-pentyl} ester IIa-40 l-(5-[Amino-hydroxy-phosphoryloxy]-5-phenyl-hexane-l-sulfmyl)-5-[amino-hydroxy-phos phoryloxy] -5 -phenyhexane IIa-41 l-[l-Methyl-l-phenyl-5-(5-phenyl-5-{tetrazol-l-yl}-hexane-l-sulfmyl)-pentyl]-lH-tetrazole IIa-42 -[ 1 -Methyl- 1 -phenyl-5 -(5 -phenyl-5 - {tetrazol-5 -yl} -hexane- 1 -sulfmyl)-pentyl] - 1 H-tetrazole IIa-43 -[l -Methyl-1 -phenyl-5-(5- {3-hydroxy-isoxazol-5-yl} -5-phenyl-hexane- 1 -sulfinyl)-pentyl]-i soxazol-3-ol IIa-44 -[l-Methyl-l-phenyl-5-(5-{3-hydroxy-isoxazol-4-yl}-5-phenyl-hexane-l-sulfinyl)-pentyl]-i soxazol-3-ol IIa-45 -[l-Methyl-l-phenyl-5-(5-{2-hydroxy-tetrahydro-pyranoxy}-5-phenyl-hexane-l-sulfinyl)-p entyloxy]-tetrahydro-pyran IIa-46 -[l-Methyl-l-phenyl-5-(5-{2-oxo-dihydro-furan-5-yl}-5-phenyl-hexane-l-sulfinyl)-pentyl] -dihydro-furan-2-one IIa-47 -[ 1 -Methyl-1 -phenyl-5-(5- {2-oxo-oxetan-4-yl} -5-phenyl-hexane-l -sulfinyl)-pentyl]-oxetan -2-one IIa-48 -[l-Methyl-l-phenyl-5-(5-{2-oxo-dihydro-furan-4-yl}-5-phenyl-hexane-l-sulfinyl)-pentyl] -dihydro-furan-2-one IIa-49 - [ 1 -Methyl- 1 -phenyl-5 -(5 - {2-oxo-dihydro-furan-3 -yl} -5 -phenyl-hexane- 1 -sulfmyl)-pentyl] -dihydro-furan-2-one IIa-50 (2-{5-[5-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-5-phenyl-hexane-l- sulfinyl] - 1 -methyl- 1 -phenyl-pentyl} -4-hydroxy-6-oxo-tetrahydro-pyran-4-yl)-acetic acid III-l 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]- propyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol ιπ-2 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]- propyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid m ~ 3 -(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]-propyl}- 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid πι-4 -(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran- -yl]-propyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-l-ol ιπ-5 -(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran- -yl] -propyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid III-6 -(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2- yl]-propyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid ιπ-7 -(6-{3-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-4-oxo-4Η-thiopyran-2-yl]-propyl}-4-oxo-4Η- thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]- propyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid III-9 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]-propyl}- 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid III-10 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran- 2-yl] -propyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol III-ll 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran- 2-yl] -propyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-12 6-(6- {3 -[6-(5-Carboxy-5 -methyl-hexyl)-4,4-dimethyl- 1 -oxo- 1 J 4-dihydro-4H-thiopyran-2- yl] -propyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-l- oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol m-14 -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-l- oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid -(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-l-oxo- hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid ιπ-16 -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-4H-thiopyran-2-yl]-vinyl}-l,4-dioxo- 4H-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol m-17 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]- vinyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid ιπ-18 -(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]-vinyl}- 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid ιπ-19 -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thioρyran- -yl]-vinyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-l -ol -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thioρyran- 2-yl]-vinyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-21 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2- yl]-vinyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-trήopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-22 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2- yl]-vinyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-23 -(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-l- oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-24 -(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-l- oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid III-25 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-4H-thiopyran-2-yl]-vinyl}-l,4 -dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol 111-26 -(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]- vinyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-27 -(6- {2-[6-(4-Carboxy-4-methyl-pentyl)- 1 ,4-dioxo-l ,4-dihydro-4H-thiopyran-2-yl]-vinyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-28 -(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pen1 l)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran- -yl]-vinyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol ιπ - 29 -(6- {2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran- 2-yl]-vinyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-30 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2- yl]-vinyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-31 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-114-thiopyran-2-yl]-ethyl}-l,4- dioxo- 114-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-l,4-dihydro-114-thiopyran-2-yl]-ethyl } - 1 ,4-dioxo-l ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-33 -(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l,4-dioxo-l,4-dihydro-114-thiopyran-2-yl]-ethyl}-l, 4-dioxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-34 -(6- {2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l ,4-dihydro- 114-thiopyran- -yl] -ethy 1} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-l 14-thiopyran-2-yl)-2,2-dimethyl-hexan-l -ol III-35 -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-114-thiopyran- 2-yl]-ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-36 -(6- {2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl] -ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-37 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-114-thiopyran-2-yl]-ethyl}-l,4 -dioxo-114-thiopyran-2-yl)-2,2-dimethyl-pentan-l-ol 111-38 -(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-l,4-dihydro-114-thiopyran-2-yl]-ethy 1} - 1 ,4-dioxo- 1 ,4-dihydro- 114-thioρyran-2-yl)-2,2-dimethyl-ρentanoic acid 111-39 -(6- {2-[6-(4-Carboxy-4-methyl-pentyl)- 1 ,4-dioxo- 1 ,4-dihydro- 114-thiopyran-2-yl]-ethyl} - 1 ,4-dioxo-l ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid -(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-114-thiopyran- -yl]-ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol ιπ-41 -(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-114-thiopyran- 2-yl] -ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-42 -(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-114-thiopyran-2-yl ]-ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-43 -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-phenyl}-l -oxo-hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol 111-44 -(6- {2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydiO-114-thiopyran-2-yl]-phenyl}-l -oxo-hexahydro-114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-45 -(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-phenyl}-l-ox o-hexahydro-ll4-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-46 6-(6- {2-[6-(6-Hydroxy-5 ,5-dimethyl-hexyl)- 1 ,4-dioxo- 114-thiopyran-2-yl] -phenyl} -1 ,4 -dioxo- 114-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol 111-47 -(6- {2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)- 1 ,4-dioxo- 1 ,4-dihydro- 114-thiopyran-2-yl]-phen yl} - 1 ,4-dioxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid III-48 -(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l,4-dioxo-l,4-dihydro-114-thiopyran-2-yl]-phenyl}- 1 ,4-dioxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid III-49 -(6- {2-[6-(6-Hydroxy-5 ,5-dimethyl-hexyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran- -yl]-phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol -(6- {2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l -oxo- 1 ,4-dihydro- 114-thiopyran- 2-yl] -phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid -(6-{2-[6-(5 -Carboxy-5 -methyl-hexyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl] -phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid 111-52 -(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-phenyl}- 1 -oxo-hexahydro- 1 i4-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol 111-53 -(6- {2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)- 1 -oxo-hexahydro- 114-thiopyran-2-yl]-phenyl} - 1 -oxo-hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid III-54 -(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-phenyl}-l-ox o-hexahydro-114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-55 -(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-l,4-dioxo-114-thiopyran-2-yl]-phenyl}-l -oxo-l,4-dioxo-114-thiopyran-2-yl)-2,2-dimethyl-pentan-l-ol 111-56 -(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-l,4-dihydro-114-thiopyran-2-yl]-phe nyl}-l,4-dioxo-l,4-dihydro-114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid III-57 -(6- {2-[6-(4-Carboxy-4-methyl-pentyl)- 1 ,4-dioxo- 1 ,4-dihydro- 114-thiopyran-2-yl]-phenyl} - 1 ,4-dioxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid 111-58 -(6- {2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran- -yl]-phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol 111-59 -(6- {2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran- 2-yl]-phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid -(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-114-thiopyran-2-yl ]-phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid ιπ-61 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-ρentyl)-l-oxo-lH-114-thioρhen-2-yl]-ρropyl}-l-oxo-l H-114-thiophen-2-yl)-2,2-dimethyl-pentan-l-ol HOOC CH 2 OH 111-62 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-lH-114-thiophen-2-yl]-propyl}-l-oxo-l H- 114-thiophen-2-yl)-2,2-dimethyl-pentanoic acid 111-63 -(5-{3-[5-(4-Carboxy-4-methyl-ρentyl)-l-oxo-lH-114-thioρhen-2-yl]-propyl}-l-oxo-lH-ll 4-thiophen-2-yl)-2,2-dimethyl-pentanoic acid 111-64 -(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-lH-114-thiophen-2-yl]-propyl}-l-oxo-lH - 114-thiophen-2-yl)-2,2-dimethyl-hexan- 1 -ol 111-65 -(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-lH-114-fhiophen-2-yl]-propyl}-l-oxo-lH -114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid III-66 -(5-{3-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-lH-114-thiophen-2-yl]-propyl}-l-oxo-lH-114 -thiophen-2-yl)-2,2-dimethyl-hexanoic acid 111-67 -(5- {2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)- 1 -oxo-tetrahydro- 114-thiophen-2-yl] -vinyl} - 1 -o xo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-hexan- 1 -ol 111-68 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-vinyl}- 1 -oxo-tetrahydro-114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid 111-69 -(5- {2-[5-(6-Hydroperoxy-5,5-dimethyl-hexyl)- 1 -oxo-tetrahydro- 114-thiophen-2-yl] -vinyl} - 1 -oxo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid πι-70 -(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-lH-114-thiophen-2-yl]-vinyl}-l-oxo-lH- 114-thiophen-2-yl)-2,2-dimethyl-hexan-l-ol ιπ-71 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-lH-U4-thiophen-2-yl]-vinyl}-l-oxo-lH- 114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid 111-72 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-lH-114-thiophen-2-yl]-vinyl}-l-oxo-lH-114- thiophen-2-yl)-2,2-dimethyl-hexanoic acid 15 HOH C CH 2 OH 111-73 _ _ 5-(5- {2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)- 1 -oxo-tetrahydro- 114-thiophen-2-yl] -vinyl} - 1 -o xo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-ρentan- 1 -ol HOH 2 C COOH 25 111-74 5 -(5 - {2-[5 -(5 -Hydroxy-4,4-dimethyl-pentyl)- 1 -oxo-tetrahydro- 114-thiophen-2-yl] -vinyl} - 1 -o xo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-pentanoic acid 30 HOOC COOH 111-75 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-vinyl}-l-oxo-t 2 etrahydro-114-thiophen-2-yl)-2,2-dimethyl-ρentanoic acid III-76 -(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-lH-114-thiophen-2-yl]-vinyl}-l-oxo-lH - 114-thiophen-2-yl)-2,2-dimethyl-pentan- 1 -ol III-77 -(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-lH-114-thiophen-2-yl]-vinyl}-l-oxo-lH -114-thiophen-2-yl)-2,2-dimethyl-pentanoic acid 111-78 -(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-lH-114-thiophen-2-yl]-vinyl}-l-oxo-lH-114 -thiophen-2-yl)-2,2-dimethyl-pentanoic acid 111-79 -(5 - {2-[5 -(6-Hydroxy-5 , 5 -dimethyl-hexyl)- 1 -oxo-tetrahydro- 114-thiophen-2-yl] -vinyl } - 1 -o xo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-hexan- 1 -ol 111-80 -(5- {2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)- 1 -oxo-tetrahydro- 114-thiophen-2-yl]-vinyl} - 1 -o xo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid ιπ-81 -(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-vinyl}-l-oxo-t etrahydro- 114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid 111-82 -(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-lH-114-thioρhen-2-yl]-vinyl}-l-oxo-lH- 114-thiophen-2-yl)-2,2-dimethyl-hexan- 1 -ol 111-83 -(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-lH-114-thiophen-2-yl]-vinyl}-l-oxo-lH- 114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid 111-84 -(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-lH-114-thiophen-2-yl]-vinyl}-l-oxo-lH-114- thiophen-2-yl)-2,2-dimethyl-hexanoic acid 111-85 -(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-lH-114-thiophen-2-yl]-ethyl}-l-oxo-lH- 114-thiophen-2-yl)-2,2-dimethyl-pentan- 1 -ol 12 / 111-86 -(5-{2-[5-(5-Hydroxy-4,4-dimethyl-ρentyl)-l-oxo-lH-114-thiophen-2-yl]-ethyl}-l-oxo-lH- 114-thiophen-2-yl)-2,2-dimethyl-pentanoic acid 111-87 -(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-lH-114-thiophen-2-yl]-ethyl}-l-oxo-lH-114- thiophen-2-yl)-2,2-dimethyl-ρentanoic acid IIIa-1 -(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-hexahyα^o-114-thiopyran-2-yl]-ρropyl}- 1 -oxo-hexahydro-114-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol IIIa-2 -(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-propyl}- 1 -oxo-hexahydro- 114-thioρyran-2-yl)-2,2-dimethyl-pentanoic acid IIIa-3 -(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-propyl}-l-ox o-hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid IIIa-4 -(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-propyl}- 1 -oxo-hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol IIIa-5 -(6- {3 - [6-(6-Hydroxy-5 , 5 -dimethyl-hexyl)- 1 -oxo-hexahydro- 114-thiopyran-2-yl] -propyl} - 1 -oxo-hexahydro- 114-tbiopyran-2-yl)-2,2-dimethyl-hexanoic acid IIIa-6 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-propyl}-l- oxo-hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid IIIa-7 -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-ethyl}-l- oxo-hexahydro-114-thiopyran-2-yl)-2,2-dimethyl-hexan-l-ol IIIa-8 -(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-ethyl}-l- oxo-hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid IIIa-9 -(6- {2-[6-(5-Carboxy-5-methyl-hexyl)- 1 -oxo-hexahydro- 114-thiopyran-2-yl]-ethyl} - 1 -oxo- hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid IIIa-10 -(6- {2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)- 1 -oxo-hexahydro- 114-thiopyran-2-yl] -ethyl} - 1 ■ oxo-hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol IIIa-11 -(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-hexahydro-114-thiopyran-2-yl]-ethyl}-l- oxo-hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid IIIa-12 -(6- {2-[6-(4-Carboxy-4-methyl-pentyl)- 1 -oxo-hexahydro- 114-thiopyran-2-yl] -ethyl} - 1 -oxo -hexahydro- 114-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid IIIa-13 -(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-propyl}-l -oxo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-pentan-l -ol IIIa-14 -(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-propyl}-l -oxo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-pentanoic acid IIIa-15 -(5-{3-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-propyl}-l-oxo -tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-pentanoic acid IIIa-16 -(5- {3-[5-(6-Hydroxy-5 ,5-dimethyl-hexyl)- 1 -oxo-tetrahydro- 114-thiophen-2-yl] -propyl} - 1 - oxo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-hexan- 1 -ol IIIa-17 -(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-propyl}-l- oxo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid IIIa-18 -(5-{3-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-texrahydro-114-thiophen-2-yl]-propyl}-l-oxo- tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-hexanoic acid HOH C CH 2 OH IIIa-19 -(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-ethyl}-l-o xo-tetrahydro- 114-thiophen-2-yl)-2,2-dimethyl-pentan- 1 -ol HOH 2 C ^^ ^^ S ^ ^ S ^^ ^^ OOH δ δ IIIa-20 -(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-ethyl}-l-o xo-tetrahydro-114-thiophen-2-yl)-2,2-dimethyl-pentanoic acid IIIa-21 -(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-tetrahydro-114-thiophen-2-yl]-ethyl}-l-oxo-t etrahydro- 114-thiophen-2-yl)-2,2-dimethyl-pentanoic acid 4.1. Definitions and Abbreviations Apo(a): apolipoprotein(a) Apo A-I: apolipoprotein A-I Apo B: apolipoprotein B 5 Apo E: apolipoprotein E FH: Familial hypercholesterolemia FCH: Familial combined hyperlipidemia GDM: Gestational diabetes mellitus HDL: High density lipoprotein H rs IDL: Intermediate density lipoprotein IDDM: Insulin dependent diabetes mellitus LDH: Lactate dehdyrogenase LDL: Low density lipoprotein Lp(a): Lipoprotein (a) , 5 MODY: Maturity onset diabetes of the young NIDDM: Non-insulin dependent diabetes mellitus PPAR: Peroxisome proliferator activated receptor RXR: Retinoid X receptor VLDL: Very low density lipoprotein 20 The compounds of the invention can contain one or more chiral centers and/or double bonds and, therefore, exist as stereoisomers, such as double-bond isomers (i.e., geometric isomers), enantiomers, or diastereomers. According to the invention, the chemical structures depicted herein, and therefore the compounds of the invention, 2 encompass all of the corresponding compound's enantiomers and stereoisomers, that is, both the stereomerically pure form (e.g., geometrically pure, enantiomerically pure, or diastereomerically pure) and enantiomeric and stereoisomeric mixtures. A compound of the invention is considered optically active or enantiomerically pure (i.e., substantially the R-form or substantially the S-form) with respect to a chiral center ™ when the compound is about 90% ee (enantiomeric excess) or greater, preferably, equal to or greater than 95% ee with respect to a particular chiral center. A compound of the invention is considered to be in enantiomerically-enriched form when the compound has an enantiomeric excess of greater than about 80% ee with respect to a particular chiral center. A compound of the invention is considered diastereomerically pure with respect to multiple ^5 chiral centers when the compound is about 90% de (diastereomeric excess) or greater, preferably, equal to or greater than 95% de with respect to a particular chiral center. A compound of the invention is considered to be in diastereomerically-enriched form when the compound has an diastereomeric excess of greater than about 80%o de with respect to a particular chiral center. As used herein, a racemic mixture means about 50% of one enantiomer and about 50% of is corresponding enantiomer relative to all chiral centers in the molecule. Thus, the invention encompasses all enantiomerically-pure, enantiomerically- 5 enriched, diastereomerically pure, diastereomerically enriched, and racemic mixtures of compounds of Formulas I through III. Enantiomeric and stereoisomeric mixtures can be resolved into their component enantiomers or stereoisomers by well known methods, such as cl iral-phase gas chromatography, chiral-phase high performance liquid chromatography, crystallizing the , r compound as a chiral salt complex, or crystallizing the compound in a chiral solvent. Enantiomers and stereoisomers can also be obtained from stereomerically- or enantiomerically-pure intermediates, reagents, and catalysts by well known asymmetric synthetic methods. The compounds of the invention are defined herein by their chemical structures 1 5 and/or chemical names. Where a compound is referred to by both a chemical structure and a chemical name, and the chemical structure and chemical name conflict, the chemical structure is determinative of the compound's identity. When administered to a patient, e.g., to an animal for veterinary use or for improvement of livestock, or to a human for clinical use, the compounds of the invention 0 ^e administered in isolated form or as the isolated form in a pharmaceutical composition. As used herein, "isolated" means that the compounds of the invention are separated from other components of either (a) a natural source, such as a plant or cell, preferably bacterial culture, or (b) a synthetic organic chemical reaction mixture. Preferably, via conventional techniques, the compounds of the invention are purified. As used herein, "purified" means 5 that when isolated, the isolate contains at least 95%), preferably at least 98%, of a single ether compound of the invention by weight of the isolate. The phrase "pharmaceutically acceptable salt(s)," as used herein includes, but are not limited to, salts of acidic or basic groups that may be present in the compounds of the invention. Compounds that are basic in nature are capable of forming a wide variety of salts 3 with various inorganic and organic acids. The acids that may be used to prepare pharmaceutically acceptable acid addition salts of such basic compounds are those that form non-toxic acid addition salts, i.e., salts containing pharmacologically acceptable anions, including, but not limited to, sulfuric, citric, maleic, acetic, oxalic, hydrochloride, hydrobromide, hydroiodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, 35 isonicotinate, acetate, lactate, salicylate, citrate, acid citrate, tartrate, oleate, tannate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate and pamoate (i.e., l,l'-methylene-bis-(2-hydroxy-3- naphthoate)) salts. Compounds of the invention that include an amino moiety also can form pharmaceutically acceptable salts with various amino acids, in addition to the acids mentioned above. Compounds of the invention that are acidic in nature are capable of 5 forming base salts with various pharmacologically acceptable cations. Examples of such salts include alkali metal or alkaline earth metal salts and, particularly, calcium, magnesium, sodium lithium, zinc, potassium, and iron salts. As used herein, the term "solvate" means a compound of the invention or a salt thereof, that further includes a stoichiometric or non-stoichiometric amount of a solvent , r . bound by non-covalent intermolecular forces. Preferred solvents are volatile, non-toxic, and/or acceptable for admimstration to humans in trace amounts. As used herein, the term "hydrate" means a compound of the invention or a salt thereof, that further includes a stoichiometric or non-stoichiometric amount of water bound by non-covalent intermolecular forces. , 5 The term "clathrate" means a compound of the invention or a salt thereof in the form of a crystal lattice that contains spaces (e.g., channels) that have a guest molecule (e.g., a solvent or water) trapped within. "Altering lipid metabolism" indicates an observable (measurable) change in at least one aspect of lipid metabolism, including but not limited to total blood lipid content, blood 2 Q HDL cholesterol, blood LDL cholesterol, blood NLDL cholesterol, blood triglyceride, blood Lp(a), blood apo A-I, blood apo E and blood non-esterifϊed fatty acids. "Altering glucose metabolism" indicates an observable (measurable) change in at least one aspect of glucose metabolism, including but not limited to total blood glucose content, blood insulin, the blood insulin to blood glucose ratio, insulin sensitivity, and 25 oxygen consumption. As used herein, the term "alkyl group" means a saturated, monovalent, unbranched or branched hydrocarbon chain. Examples of alkyl groups include, but are not limited to, (C j -C^alkyl groups, such as methyl, ethyl, propyl, isopropyl, 2-methyl-l -propyl, 2-methyl-2-proρyl, 2-methyl-l -butyl, 3 -methyl- 1-butyl, 2-methyl-3 -butyl, 2,2-dimethyl-l- ™ propyl, 2-methyl-l -pentyl, 3 -methyl- 1-pentyl, 4-methyl-l-pentyl, 2-methyl-2-pentyl, 3- methyl-2-pentyl, 4-methyl-2-pentyl, 2,2-dimethyl- 1-butyl, 3,3-dimethyl-l-butyl, 2-ethyl-l- butyl, butyl, isobutyl, t-butyl, pentyl, isopentyl, neopentyl, and hexyl, and longer alkyl groups, such as heptyl, and octyl. An alkyl group can be unsubstituted or substituted with one or two suitable substituents. ~5 An "alkenyl group" means a monovalent, unbranched or branched hydrocarbon chain having one or more double bonds therein. The double bond of an alkenyl group can be unconjugated or conjugated to another unsaturated group. Suitable alkenyl groups include, but are not limited to (C 2 -C 6 )alkenyl groups, such as vinyl, allyl, bixtenyl, pentenyl, hexenyl, butadienyl, pentadienyl, hexadienyl, 2-ethylhexenyl, 2-propyl-2-butenyl, 4-(2- methyl-3-butene)-pentenyl. An alkenyl group can be unsubstituted or substituted with one or two suitable substituents. An "alkynyl group" means monovalent, unbranched or branched hydrocarbon chain having one or more triple bonds therein. The triple bond of an alkynyl group can be unconjugated or conjugated to another unsaturated group. Suitable alkynyl groups include, but are not limited to, (C 2 -C 6 )alkynyl groups, such as ethynyl, propynyl, butynyl, pentynyl, hexynyl, methylpropynyl, 4-methyl-l -butynyl, 4-propyl-2-pentynyl, and 4-butyl-2-hexynyl. An alkynyl group can be unsubstituted or substituted with one or two suitable substituents. An "aryl group" means a monocyclic or polycyclic-aromatic radical comprising carbon and hydrogen atoms. Examples of suitable aryl groups include, but are not limited to, phenyl, tolyl, anthacenyl, fluorenyl, indenyl, azulenyl, and naphthyl, as well as benzo- fused carbocyclic moieties such as 5,6,7,8-tetrahydronaphthyl. An aryl group can be unsubstituted or substituted with one or two suitable substituents. Preferably, the aryl group is a monocyclic ring, wherein the ring comprises 6 carbon atoms, referred to herein as "( )aryl". A "heteroaryl group" means a monocyclic- or polycyclic aromatic ring comprising carbon atoms, hydrogen atoms, and one or more heteroatoms, preferably 1 to 3 heteroatoms, independently selected from nitrogen, oxygen, and sulfur. Illustrative examples of heteroaryl groups include, but are not limited to, pyridinyl, pyridazinyl, pyrimidyl, pyrazyl, triazinyl, pyrrolyl, pyrazolyl, imidazolyl, (1,2,3,)- and (l,2,4)-triazolyl, pyrazinyl, pyrimidinyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, furyl, phienyl, isoxazolyl, and oxazolyl. A heteroaryl group can be unsubstituted or substituted with one or two suitable substituents. Preferably, a heteroaryl group is a monocyclic ring, wherein the ring comprises 2 to 5 carbon atoms and 1 to 3 heteroatoms, referred to herein as "(C 2 -C 5 )heteroaryl". A "cycloalkyl group" means a monocyclic or polycyclic saturated ring comprising carbon and hydrogen atoms and having no carbon-carbon multiple bonds. Examples of cycloalkyl groups include, but are not limited to, (C 3 -C 7 )cycloalkyl groups, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and cycloheptyl, and saturated cyclic and bicyclic terpenes. A cycloalkyl group can be unsubstituted or substituted by one or two suitable substituents. Preferably, the cycloalkyl group is a monocyclic ring or bicyclic ring. A "heterocycloalkyl group" means a monocyclic or polycyclic ring comprising carbon and hydrogen atoms and at least one heteroatom, preferably, 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur, and having no unsaturation. Examples of heterocycloalkyl groups include pyrrolidinyl, pyrrolidino, piperidinyl, piperidino, piperazinyl, piperazino, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino, and pyranyl. A heterocycloalkyl group can be unsubstituted or substituted with one or two suitable substituents. Preferably, the heterocycloalkyl group is a monocyclic or bicyclic ring, more preferably, a monocyclic ring, wherein the ring comprises from 3 to 6 carbon 5 atoms and form 1 to 3 heteroatoms, referred to herein as As used herein a "heterocyclic radical" or "heterocyclic ring" means a heterocycloalkyl group or a heteroaryl group. The term "alkoxy group"means an -O-alkyl group, wherein alkyl is as defined above. An alkoxy group can be unsubstituted or substituted with one or two suitable . r . substituents. Preferably, the alkyl chain of an alkyloxy group is from 1 to 6 carbon atoms in length, referred to herein as "(C,-C 6 )alkoxy". The term "aryloxy group" means an -O-aryl group, wherein aryl is as defined above. An aryloxy group can be unsubstituted or substituted with one or two suitable substituents. Preferably, the aryl ring of an aryloxy group is a monocyclic ring, wherein the , 5 ring comprises 6 carbon atoms, referred to herein as "(C 6 )aryloxy". The term "benzyl" means -CH 2 -phenyl. The term "phenyl" means -C 6 H 5 . A phenyl group can be unsubstituted or substituted with one or two suitable substituents. A "hydrocarbyl" group means a monovalent group selected from (C r C g )alkyl, (C--C 8 )alkenyl, and (C 2 -C 8 )alkynyl, optionally substituted with one or two suitable substituents. Preferably, the hydrocarbon chain of a hydrocarbyl group is from 1 to 6 carbon atoms in length, referred to herein as "(C 1 -C 6 )hydrocarbyl". A "carbonyl" group is a divalent group of the formula -CO-. An "alkoxycarbonyl" group means a monovalent group of the formula -CO-alkoxy. 5 Preferably, the hydrocarbon chain of an alkoxycarbonyl group is from 1 to 8 carbon atoms in length, referred to herein as a "lower alkoxycarbonyl" group. A "carbamoyl" group means the radical -CON(R') 2 , wherein R' is chosen from the group consisting of hydrogen, alkyl, and aryl. As used herein, "halogen" means fluorine, chlorine, bromine, or iodine. ^ Correspondingly, the meaning of the terms "halo" and "HaP'encompass fluoro, chloro, bromo, and iodo. As used herein, a "suitable substituent" means a group that does not nullify the synthetic or pharmaceutical utility of the compounds of the invention or the intermediates useful for preparing them. Examples of suitable substituents include, but are not limited to: 5 (C 1 -C 8 )alkyl; (C 1 -C 8 )alkenyl; (C 1 -C 8 )alkynyl; (C 6 )aryl; (C 2 -C 5 )heteroaryl; (C 3 -C 7 )cycloalkyl; ( -C^alkoxy; (C 6 )aryloxy; -CN; -OH; oxo; halo, -CO 2 H; - H 2 ; -NH((C 1 -C 8 )alkyl); -N^C.-C^alkyl),; - H((C 6 )aryl); -N((C 6 )aryl) 2 ; -CHO; and -CO 2 ((C 6 )aryl). One of skill in art can readily choose a suitable substituent based on the stability and pharmacological and synthetic activity of the compound of the invention. 4.2. Synthesis of the Compounds of the Invention The compounds of the invention can be obtained via the synthetic methodology illustrated in Schemes 1-14. Starting materials useful for preparing the compounds of the invention and intermediates thereof, are commercially available or can be prepared from commercially available materials using known synthetic methods and reagents. Scheme 1: Synthesis of Compounds of Formula 10 protection 9a 10b 10: n= 0 11 12 13 14 10: n= l carbon lation 10 15 16 10, wherein n is an integer ranging from 2 to 5 Scheme 1 illustrates the synthesis of mono-protected diols of the formula 10, wherein n is an integer ranging from 0 to 4 and R 1 and R 2 are as defined above. Scheme 1 first outlines the synthesis of mono-protected diols 10, wherein n is 0, where esters 7 are successively reacted with a first ((R') p -M) then a second ((R 2 ) p -M) organometallic reagent providing ketones 8 and alcohols 9, respectively. M is a metal and p is the metal's valency value (e.g., the valency of Li is 1 and that of Zn is 2). Suitable metals include, but are not limited to, Zn, Na, Li, and -Mg-Hal, wherein Hal is a halide selected from iodo, bromo, or chloro. Preferably, M is -Mg-Hal, in which case the organometallic reagents, (R^ p -Mg-Hal and (R 2 ) p -Mg-Hal, are known in the art as Grignard reagents. Esters 7 are available commercially (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or can be prepared by well-known synthetic methods, for example, via esterification of the appropriate 5-halovaleric acid (commercially available, e.g., Aldrich Chemical Co., Milwaukee, Wisconsin). Both (R^-M and (R 2 ) p -M are available commercially (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or can be prepared by well-known methods (see e.g., Kharasch et ah, Grignard Reactions of Non-Metallic Substances; Prentice-Hall, Englewood Cliffs, NJ, pp. 138-528 (1954) and Hartley; Patai, The Chemistry of the Metal- Carbon Bond, Vol. IN, Wiley: New York, pp. 159-306 and pp. 162-175 (1989), both citations are incorporated by reference herein). The reaction of a first ((R J ) p -M) then a second ((R 2 ) p -M) organometallic reagent with esters 7 can be performed using the general procedures referenced in March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 920-929 and Eicher, Patai, The Chemistry of the Carbonyl Group, pt. 1, pp. 621-693; Wiley: New York, (1966), incorporated by reference herein. For example, the synthetic procedure described in Comins et ah, 1981 ,Tetrahedron Lett. 22:1085, incorporated by reference herein, can be used. As one example, the reaction can be performed by adding an organic solution of (R^-M (about 0.5 to about 1 equivalents) to a stirred, cooled (about 0°C to about -80°C) solution comprising esters 7, under an inert atmosphere (e.g., nitrogen) to give a reaction mixture comprising ketones 8. Preferably, (R^ -M is added at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. The progress of the reaction can be followed by using an appropriate analytical method, such as thin-layer chromatography or high-performance-liquid chromatography. Next, an organic solution of (R 2 ) p -M (about 0.5 to about 1 equivalent) is added to the reaction mixture comprising ketones 8 in the same manner used to add (R') p -M. After the reaction providing alcohols 9 is substantially complete, the reaction mixture can be quenched and the product can be isolated by workup. Suitable solvents for obtaining alcohols 9 include, but are not limited to, dichloromethane, diethyl ether, tetrahydrofuran, benzene, toluene, xylene, hydrocarbon solvents (e.g., pentane, hexane, and heptane), and mixtures thereof. Preferably, the organic solvent is diethyl ether or tetrahydrofuran. Next, alcohols 9 are converted to mono- protected diols 10, wherein n is 0, using the well-known Williamson ether synthesis. This involves reacting alcohols 9 with " O-PG, wherein -PG is a hydroxy-protecting group. For a general discussion of the Williamson ether synthesis, see March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 386-387, and for a list of procedures and reagents useful in the Williamson ether synthesis see Larock Comprehensive Organic Transformations; NCH: New York, 1989, pp. 446-448, both of which references are incorporated herein by reference. As used herein, a "hydroxy- protecting group" means a group that is reversibly attached to a hydroxy moiety that renders the hydroxy moiety unreactive during a subsequent reaction(s) and that can be selectively cleaved to regenerate the hydroxy moiety once its protecting purpose has been served. Examples of hydroxy-protecting groups are found in Greene, T.W., Protective Groups in 5 Organic Synthesis, 3rd edition 17-237 (1999), incorporated herein by reference. Preferably, the hydroxy-protecting group is stable in a basic reaction medium, but can be cleaved by acid. Examples of suitable base-stable acid-labile hydroxy-protecting groups suitable for use with the invention include, but are not limited to, ethers, such as methyl, methoxy methyl, methylthiomethyl, methoxyethoxymethyl, &zs(2-chloroethoxy)methyl, i tetrahydropyranyl, tetrahydrothiopyranyl, tetrahyrofuranyl, tetrahydrothiofuranyl, 1- ethoxyethyl, 1 -methyl- 1-methoxyethyl, t-butyl, allyl, benzyl, o-nitrobenzyl, triphenylmethyl, α-naphthyldiphenylmethyl, jp-methoxyphenyldiphenylmethyl, 9-(9-phenyl- 10-oxo)anthranyl, trimethylsilyl, isopropyldimethylsilyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, tribenzylsilyl, and triisopropylsilyl; and esters, such as pivaloate, adamantoate, and 2,4,6- 15 triniethylbenzoate. Ethers are preferred, particularly straight chain ethers, such as methyl ether, methoxymethyl ether, methylthiomethyl ether, methoxyethoxymethyl ether, bis(2- chloroethoxy)methyl ether. Preferably -PG is methoxymethyl (CH 3 OCH 2 -). Reaction of alcohols 9 with " O-PG under the conditions of the Williamson ether synthesis require the protection of the hydroxy group. Alcohols 9 are protected with a base-labile protecting 0 group, but stable in the presence of nucleophiles or NaH, NA or other metals used in the next step. Protecting groups recommended for this step are: pivaloate, 2,4,6- trimethylbenzoate (mesitoate), alkylmethyl carbonate, or other similar reagents described in Greene, T.W., Protective Groups in Organic Chemistry, p. 170-178. In a typical experiment, the alcohol 9 is treated with an acid chloride or an anhydride in the presence of 5 a suitable base preferably pyridine or dimethylammo-pyridine in a temperature range of - 20 °C to 100°C, preferrably at 0°C, for various periods of time, from a few hours to a few days. The reaction may occur with or without the presence of a solvent, with the base catalyst acting as one, or if a solvent is required dichloromethane, tetrachloroethylene, and toluene are preferred. The protected alcohols 9a are then subjected to the Williamson ether 30 sythesis, which involves adding a base to a stirred organic solution comprising HO-PG (e.g., methoxymethanol), maintained at a constant temperature within the range of about 0°C to about 80 °C, preferably at about room temperature. Preferably, the base is added at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. The base can be added as an organic solution or in undiluted form. Preferably, the base will have a base strength sufficient to deprotonate a proton, wherein the proton has a pK a of greater than about 15, preferably greater than about 20. As is well known in the art, the pK, is a measure of the acidity of an acid H-A, according to the equation pK-. = -log K,, wherein E^ is the equilibrium constant for the proton transfer. The acidity of an acid H-A is proportional to the stability of its conjugate base " A. For tables listing pK^ values for various organic acids and a discussion on pK^ measurement, see March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 248-272, incorporated herein by reference. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, n-butyllithium, tert-butyllithium, iSec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium ι Q dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride. The preferred base is lithium diisopropylamide. Solvents suitable for reacting alcohols 9a with -OPG include, but are not limited, to dimethyl sulfoxide, dichloromethane, ethers, and mixtures thereof, preferably tefrahydrofuran. After addition of the base, the reaction mixture can be adjusted to within a j temperature range of about 0°C to about room temperature and alcohols 9a can be added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. Alcohols 9a can be diluted in an organic solvent or added in their undiluted form. The resulting reaction mixture is stirred until the reaction is substantially complete as determined by using an appropriate analytical 0 method, preferably by gas chromatography, then the bis-protected diols 10b can be isolated by workup and purification. Bis-protected diols 9 are further treated with a suitable base or nucleophile to remove the GG protection. The Preferred reagent for this purpose is lithium aluminum hydride, using as a solvent THF, diethyl ether, diisopropyl ether, t-butyl-methyl ether or mixture of solvents, at temperatures ranging from -20°C to 50°C, and reaction 5 times from 1 hour to 24 hours. Such procedures are extensively described in Greene, T. W., Protective Groups in Organic Chemistry, p. 170-178. The workup of the resulting reaction mixture is performed when the deprotection is complete, which is determined by using the appropriate analytical method, such as thin-layer chromatography or HPLC. Alcohols IX are isolated from the reaction mixture by methods well-known in the art. 30 Next, Scheme 1 outlines a method useful for synthesizing mono-protected diols 10, wherein n is 1. First, compounds 11, wherein E is a suitable leaving group, are reacted with compounds 12, wherein R 1 and R 2 are as defined above and R 8 is H, ( -C^alkyl or (C 6 )aryl, providing compounds 13. Suitable leaving groups are well known in the art, for example, but not limited to halides, such as chloride, bromide, and iodide; 35 aryl- or alkylsulfonyloxy, substituted arylsulfonyloxy (e.g., tosyloxy or mesyloxy); subst tuted alkylsulfonyloxy (e.g., haloalkylsulfonyloxy); phenoxy or subsituted phenoxy; and acyloxy groups. Compounds 11 are available commercially (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or can be prepared by well-known methods such as halogenation or sulfonation of butanediol. Compounds 12 are also available commercially (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or by well-known methods, such as those listed in Larock Comprehensive Organic Transformations; Wiley-NCH: New York, 1999, pp. 1754-1755 and 1765. A review on alkylation of esters of type 12 is given in J. Mulzer in Comprehensive Organic Functional Transformations, Pergamon, Oxford 1995, pp. 148-151 and exemplary synthetic procedures for reacting compounds 11 with compounds 12 are described in United States Patent No. 5,648,387, column 6 and Ackerly, et ah, 1995, J. Med. Chem. 1608. all of which citations are incorporated by reference herein. The reaction requires the presence of a suitable base. Preferably, a suitable base will have a pK- a of greater than about 25, more preferably greater than about 30. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, n-butyllithium, tert-butyllithium, -fec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; hydride bases such as sodium hydride and potassium hydride. Metal amide bases, such as lithium diisopropylamide are preferred. Preferably, to react compounds 11 with compounds 12, a solution of about 1 to about 1.2 equivalents of a suitable base is added to a stirred solution comprising esters 12 and a suitable organic solvent, under an inert atmosphere, the solution maintained at a constant temperature within the range of about -95 °C to about room temperature, preferably at about -78 °C to about -20 °C. Preferably, the base is diluted in a suitable organic solvent before addition. Preferably, the base is added at a rate of about 1.5 moles per hour. Organic solvents suitable for the reaction of compounds 11 with the compounds 12 include, but are not limited to, dichloromethane, diethyl ether, tefrahydrofuran, benzene, toluene, xylene, hydrocarbon solvents (e.g., pentane, hexane, and heptane), and mixtures thereof. After addition of the base, the reaction mixture is allowed to stir for about 1 to about 4 hours, and a compound 11, preferably dissolved in a suitable organic solvent, is added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. After addition of compounds 11, the reaction-mixture temperature can be adjusted to within a temperature range of about -20 °C to about room temperature, preferably to about room temperature, and the reaction mixture is allowed to stir until the reaction is substantially complete as determined by using an appropriated analytical method, preferably thin-layer chromatography or high-performance liquid chromatography. Then the reaction mixture is quenched and compounds 13, wherein n is 1 can be isolated by workup. Compounds 14 are then synthesized by reacting compounds 13 with " O-PG according to the protocol described above for reacting alcohols 9 with " O-PG. Next, compounds 14 can be converted to mono- protected diols 10, wherein n is 1, by reduction of the ester group of compounds 14 to an alcohol group with a suitable reducing agent. A wide variety of reagents are available for reduction of such esters to alcohols, e.g., see M. Hudlicky, Reductions in Organic Chemistry, 2nd ed., 1996 pp. 212-217, incorporated by reference herein. Preferably, the reduction is effected with a hydride type reducing agent, for example, lithium aluminum hydride, lithium borohydride, lithium triethyl borohydride, diisobutylaluminum hydride, lithium trimethoxyalummum hydride, or sodium fe(2-methoxy)aluminum hydride. For exemplary procedures for reducing esters to alcohols, see Nystrom et ah, 1947, J. Am. Chem. Soc. 69:1197; and Moffet et ah, 1963, Org. Synth., Collect. 834(4), lithium aluminum hydride; Brown et ah, 1965, J. Am. Chem. Soc. 87:5614, lithium trimethoxyalummum hydride; Cerny et ah, 1969, Collect. Czech. Chem. Commun. 34:1025, sodium tø(2-methoxy)alιmιinum hydride; Nystrom et ah, 1949, J Am. Chem. 71:245, lithium borohydride; and Brown et ah, 1980, J. Org. Chem. 45:1, lithium triethyl borohydride, all of which citations are incorporated herein by reference. Preferably, the reduction is conducted by adding an organic solution of compounds 14 to a stirred mixture comprising a reducing agent, preferably lithium aluminum hydride, and an organic solvent. During the addition, the reaction mixture is maintained at a constant temperature within the range of about -20 °C to about 80 °C, preferably at about room temperature. Organic solvents suitable for reacting 13 with -OPG include, but are not limited to, dichloromethane, diethyl ether, tetrahydrofuran or mixtures thereof, preferably tetrahydrofuran. After the addition, the reaction mixture is stirred at a constant temperature within the range of about room temperature to about 60 °C, until the reaction is substantially complete as determined by using an appropriate analytical method, preferably thin-layer chromatography or high-performance-liquid chromatography. Then the reaction mixture can be quenched and mono-protected diols 10, wherein n is 1, can be isolated by workup and purification. Scheme 1 next illustrates a three step synthetic sequence for homologating mono-protected diols 10 comprising: (a) halogenation ( converting -CH 2 OH to -CH 2 -Hal); (b) carbonylation (replacing -Hal with -CHO); and (c) reduction (converting -CHO to -CH 2 OH), wherein a reaction sequence of (a), (b), and (c) increases the value of n by 1. In step (a) protected halo-alcohols 15, wherein Hal is a halide selected from the group of chloro, bromo, or iodo, preferably iodo, can be prepared by halogenating mono-protected diols 10, by using well-known methods (for a discussion of various methods for conversion of alcohols to halides see March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 431-433, incorporated herein by reference). For example, protected iodo-alcohols 15 can be synthesized starting from mono-protected diols 10 by treatment with Ph 3 /I 2 /imidazole (Garegg et ah, 1980, J. C.SPerkin 72866 ); 1,2-dipheneylene phosphorochloridite/I 2 (Corey et ah, 1967, J. Org. Chem. 82:4160); or preferably with Me 3 SiCl/NaI (Olah et ah, 1979, J. Org. Chem. 44:8, 1247), all of which citations are 5 incorporated by reference herein. Step (b); carbonylation of alkyl halides, such as protected halo-alcohols 15, is reviewed in Olah et ah, 1987, Chem Rev. 87:4, 671; and March, L, Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 483-484, both of which are incorporated by reference herein). Protected halo-alcohols 15 can be carbonylated with Li(BF 3 »Et 2 O)/HCONMe 2 using the procedure described in 10 Maddaford et ah, 1993, J Org. Chem. 58:4132; Becker et ah, 1982, J Org. Chem. 3297; or Myers et ah, 1992, J. Am. Chem. Soc. 114:9369 or, alternatively, with an organometallic/N- formylmorpholine using the procedure described in Olah et ah, 1984, J. Org. Chem. 49:3856 or Nogtle et ah, 1987, J. Org. Chem. 52:5560, all of which citations are incorporated by reference herein. The method described in Olah et ah, 1984, J. Org. Chem. 49:3856 is 15 preferred. Reduction step (c) useful for synthesizing mono-protected diols 10 from aldehydes 16, can be accomplished by well-known methods in the art for reduction of aldehydes to the corresponding alcohols (for a discussion see M. Hudlicky, Reductions in Organic Chemistry, 2nd ed., 1996 pp 137-139), for example, by catalytic hydrogenation (see e.g., Carothers, 1949, J. Am. Chem .Soc. 46:1675) or, preferably by reacting aldehydes 20 16 with a hydride reducing agent, such as lithium aluminum hydride, lithium borohydride, sodium borohydride (see e.g., the procedures described in Chaikin et ah, 1949, J. Am. Chem. Soc. 71:3245; Nystrom et ah, 19 l, J. Am. Chem. Soc. 69:1197; and Nystrom et ah, 1949, J Am. Chem. 71:3245, all of which are incorporated by reference herein). Reduction with lithium aluminum hydride is preferred. 25 30 35 Scheme 2: Synthesis of Compounds of Formula 18a, which correspond to Compounds W (1)(2) -Z m -OH. Wherein W (1)(2) is CfR 1 M 2 >-Y 16 Scheme 2 outlines methodology for the synthesis of protected alcohols 18a wherein Y, R 1 , R 2 , Z, and m are defined as above. Protected alcohols 18a correspond to compounds of the formula W (1)(2) -Zm-OPG, wherein W (1)(2) is C(R 1 )(R )-Y. Protected alcohols 17, wherein Y comprises a -COOH group, can be synthesized by oxidizing mono-protected diols 10 with an agent suitable for oxidizing a primary alcohol to a carboxylic acid (for a discussion see M. Hudlicky, Oxidations in Organic Chemistry, ACS Monograph 186, 1990, pp. 127-130, incorporated by reference herein). Suitable oxidizing agents include, but are not limited to, pyridinium dichromate (Corey et ah, 1979, Tetrahedron Lett. 399 ); manganese dioxide (Ahrens et ah, 1967, J. Heterocych Chem. 4:625); sodium permanganate monohydrate (Menger et ah, 1981, Tetrahedron Lett. 22:1655); and potassium permanganate (Sam et ah, 1972, J. Am. Chem. Soc. 94:4024), all of which citations are incorporated by reference herein. The preferred oxidizing reagent is pyridinium dichromate. In an alternative synthetic procedure, protected alcohols 17, wherein Y comprises a -COOH group, can be synthesized by treatment of protected halo- alcohols 15, wherein Hal is iodo, with CO or CO 2 , as described in Bailey et ah, 1990, J Org. Chem. 55:5404 and Yanagisawa et ah, 1994, J Am. Chem. Soc. 116:6130, the two of which citations are incorporated by reference herein. Protected alcohols 17, wherein Y comprises -COOR 5 , wherein R 5 is as defined above, can be synthesized by oxidation of mono- protected diols 10 in the presence of R 5 OH (see generally, March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 1196). An exemplary procedure for such an oxidation is described in Stevens et ah, 1982, Tetrahedron Lett. 23:4647 (HOC1); Siindararaman et α/., 1978, Tetrahedron Lett. 1627 (O 3 /KOH); Wilson et α/., 1982, J Org. Chem. 47:1360 (t-BuOOH/Et 3 N); and Williams et α/., 1988, Tetrahedron Lett. 29:5087 (Br 2 ), the four of which citations are incorporated by reference herein. Preferably, protected alcohols 17, wherein Y comprises a -COOR 5 group are synthesized from the corresponding carboxylic acid (i.e., 17, wherein Y comprises -COOH) by esterification with R 5 OH (e.g., see March, , Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 393-394, incorporated by reference herein). In another alternative synthesis, protected alcohols 17, wherein Y comprises -COOR 5 , can be prepared from protected halo-alcohols 15 by carbonylation with transition metal complexes (see e.g., March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 484-486; Urata et ah, 1991, Tetrahedron Lett. 32:36, 4733); and Ogata et ah, 1969, J. Org. Chem. 3985, the three of which citations are incorporated by reference herein). Protected alcohols 17, wherein Y comprises -OCOR 5 , wherein R 5 is as defined above, can be prepared by acylation of mono-protected diols 10 with a carboxylate equivalent such as an acyl halide (i.e., R 5 CO-Hal, wherein Hal is iodo, bromo, or chloro, see e.g., March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 392 and Org. Synth. Coll. Vol. m, Wiley, NY, pp. 142, 144, 167, and 187 (1955)) or an anhydride (i.e., R 5 CO-O-OCR 5 , see e.g., March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 392-393 and Org. Synth. Coll. Vol. m, Wiley, NY, pp. 11, 127, 141, 169, 237, 281, 428, 432, 690, and 833 (1955), all of which citations are incorporated herein by reference). Preferably, the reaction is conducted by adding a base to a solution comprising mono-protected diols 10, a carboxylate equivalent, and an organic solvent, which solution is preferably maintained at a constant temperature within the range of 0°C to about room temperature. Solvents suitable for reacting mono-protected diols 10 with a carboxylate equivalent include, but are not limited to, dichloromethane, toluene, and ether, preferably dichloromethane. Suitable bases include, but are not limited to, hydroxide sources, such as sodium hydroxide, potassium hydroxide, sodium carbonate, or potassium carbonate; or an amine such as triethylamine, pyridine, or dimethylaminopyridine. The progress of the reaction can be followed by using an appropriate analytical technique, such as thin layer chromatography or high performance liquid chromatography and when substantially complete, the product can be isolated by workup and purified if desired. Protected alcohols 17, wherein Y comprises one of the following phosphate ester groups wherein R 6 is defined as above, can be prepared by phosphorylation of mono-protected diols 10 according to well-known methods (for a general reviews, see Corbridge Phosphorus: An Outline of its Chemistry, Biochemistry, and Uses, Studies in Inorganic Chemistry, 3rd ed., pp. 357-395 (1985); Ramirez et ah, 1978, Ace. Chem. Res. 11:239; and Kalckare Biological Phosphorylations, Prentice-Hall, New York (1969); J. B. Sweeny in Comprehensive Organic Functional Group Transformations, A.R. Katritzky, O. Meth-Cohn and C.W. Rees, Eds. Pergamon: Oxford, 1995, vol 2, pp. 104-109, the four of which are incorporated herein by reference). Protected alcohols 17 wherein Y comprises a monophosphate group of the formula: wherein R 6 is defined as above, can be prepared by treatment of mono-protected diol 10 with phosphorous oxychloride in a suitable solvent, such as xylene or toluene, at a constant temperature within the range of about 100°C to about 150°C for about 2 hours to about 24 hours. After the reaction is deemed substantially complete, by using an appropriate analytical method, the reaction mixture is hydrolyzed with R 6 -OH. Suitable procedures are referenced in Houben-Weyl, Methoden der Organische Chemie, Georg Thieme Verlag Stuttgart 1964, vol. Xπ/2, pp. 143-210 and 872-879, incorporated by reference herein. Alternatively, when both R 6 are hydrogen, can be synthesized by reacting mono-protected diols 10 with silyl polyphosphate (Okamoto et /.,1985, Bull Chem. Soc. Jpn. 58:3393. incorporated herein by reference) or by hydrogenolysis of their benzyl or phenyl esters (Chen et ah, 1998, J. Org. Chem. 63:6511, incorporated herein by reference). In another alternative procedure, when R 6 is (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl, the monophosphate esters can be prepared by reacting mono-protected diols 10 with appropriately substituted phophoramidites followed by oxidation of the intermediate with wz-chloroperbenzoic acid (Yu et ah, 1988, Tetrahedron Lett. 29:979, incorporated herein by reference) or by reacting mono-protected diols 10 with dialkyl or diaryl substituted phosphorochloridates (Pop, et al,l991, Org. Prep, and Proc. Int. 29:341, incorporated herein by reference). The phosphoramidites are commercially available (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or readily prepared according to literature procedures (see e.g., Uhlmann et al.1986, Tetrahedron Lett. 27:1023 and Tanaka et ah, 1988, Tetrahedron Lett. 29:199, both of which are incorporated herein by reference). The phosphorochloridates are also commercially available (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or prepared according to literature methods (e.g., Gajda et α/,1995, Synthesis 25:4099. hi still another alternative synthesis, protected alcohols 17, wherein Y comprises a monophosphate group and R 6 is alkyl or aryl, can be prepared by reacting IP + (OR 6 ) 3 with mono-protected diols 10 according to the procedure described in Stowell et ah, 1995, Tetrahedron Lett. 36:11, 1825 or by alkylation of protected halo alcohols 15 with the appropriate dialkyl or diaryl phosphates (see e.g., Okamoto, 1985, Bull Chem. Soc. Jpn. 58:3393, incorporated herein by reference). Protected alcohols 17 wherein Y comprises a diphosphate group of the formula wherein R 6 is defined as above, can be synthesized by reacting the above-discussed monophosphates of the formula: with a phosphate of the formula (commercially available, e.g., Aldrich Chemical Co., Milwaukee, Wisconsin), in the presence of carbodiimide such as dicyclohexylcarbodumide, as described in Houben-Weyl, Methoden der Organische Chemie, Georg Thieme Nerlag Stuttgart 1964, vol. XUJ2, pp. 881-885. hi the same fashion, protected alcohols 17, wherein Y comprises a triphosphate group of the formula: can be synthesized by reacting the above-discussed diphosphate protected alcohols, of the formula: with a phosphate of the formula: as described above. Alternatively, when R 6 is H, protected alcohols 17 wherein Y comprises the triphosphate group, can be prepared by reacting mono-protected diols 10 with salicyl phosphorochloridite and then pyrophosphate and subsequent cleavage of the adduct thus obtained with iodine in pyridine as described in Ludwig et ah, 1989, J Org. Chem. 54:631 , incorporated herein by reference. Protected alcohols 17, wherein Y is -SO 3 H or a heterocyclic group selected from the group consisting of: can be prepared by halide displacement from protected halo-alcohols 15. Thus, when Y is -SO 3 H, protected alcohols 17 can by synthesized by reacting protected halo-alcohols 15 with sodium sulfite as described in Gilbert Sulfonation and Related Reactions; Wiley: New York, 1965, pp. 136-148 and pp. 161-163; Org. Synth. Coll. Vol. H, Wiley, NY, 558, 564 (1943); and Org. Synth. Coll. Vol. IN, Wiley, ΝY, 529 (1963), all three of which are incorporated herein by reference. When Y is one of the above-mentioned heterocycles, protected alcohols 17 can be prepared by reacting protected halo-alcohols 15 with the corresponding heterocycle in the presence of a base. The heterocycles are available commercially (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or prepared by well- known synthetic methods (see the procedures described in Ware, 1950, Chem. Rev. 46:403- 470, incorporated herein by reference). Preferably, the reaction is conducted by stirring a mixture comprising 15, the heterocycle, and a solvent at a constant temperature within the range of about room temperature to about 100°C, preferably within the range of about 50 °C 10 to about 70 °C for about 10 to about 48 hours. Suitable bases include hydroxide bases such as sodium hydroxide, potassium hydroxide, sodium carbonate, or potassium carbonate. Preferably, the solvent used in forming protected alcohols 17 is selected from dimethylformamide; formamide; dimethyl sulfoxide; alcohols, such as methanol or ethanol; and mixtures thereof. The progress of the reaction can be followed by using an appropriate 15 analytical technique, such as thin layer chromatography or high performance liquid cliromatography and when substantially complete, the product can be isolated by workup and purified if desired. Protected alcohols 17, wherein Y is a heteroaryl ring selected from 25 can be prepared by metallating the suitable heteroaryl ring then reacting the resulting metallated heteroaryl ring with protected halo-alcohols 15 (for a review, see Katritzky Handbook of Heterocyclic Chemistry, Pergamon Press: Oxford 1985). The heteroaryl rings are available commercially or prepared by well-known synthetic methods (see e.g., Joule et ah, Heterocyclic Chemistry, 3rd ed., 1995; De Sarlo et /.,1971, J. Chem. Soc. (C) 86; Osier 30 et ah, 1983, J. Org. Chem. 48:4307; Iwai et ah, 1966, Chem. Pharm. Bull. 14:1211; and United States Patent No. 3,152,148, all of which citations are incorporated herein by reference). As used herein, the term "metallating" means the forming of a carbon-metal bond, which bond may be substantially ionic in character. Metallation can be accomplished by adding about 2 equivalents of strong organometallic base, preferably with a pE^ of about 35 25 or more, more preferably with a pK, of greater than about 35, to a mixture comprising a suitable organic solvent and the heterocycle. Two equivalents of base are required: one equivalent of the base deprotonates the -OH group or the — NH group, and the second equivalent metallates the heteroaryl ring. Alternatively, the hydroxy group of the heteroaryl ring can be protected with a base-stable, acid-labile protecting group as described in Greene, T.W., Protective Groups in Organic Synthesis, 3rd edition 17-237 (1999), incorporated herein by reference. Where the hydroxy group is protected, only one equivalent of base is required. Examples of suitable base-stable, acid-labile hydroxyl-protecting groups, include but are not limited to, ethers, such as methyl, methoxy methyl, methylthiomethyl, methoxyethoxymethyl, tø(2-chloroethoxy)methyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahyrofuranyl, tetrahy&othiofuranyl, 1-ethoxyethyl, 1 -methyl- 1- methoxyethyl, t-butyl, allyl, benzyl, o-nitrobenzyl, triphenylmethyl, α- Q naphthyldiphenylmethyl, j5-methoxyphenyldiphenylmethyl, 9-(9-phenyl- 10-oxo)anthranyl, trimethylsilyl, isopropyldimethylsilyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, tribenzylsilyl, triisopropylsilyl; and esters, such as pivaloate, adamantoate, and 2,4,6- trimethylbenzoate. Ethers are preferred, particularly straight chain ethers, such as methyl ether, methoxymethyl ether, methylthiomethyl ether, methoxyethoxymethyl ether, bis(2- 5 chloroethoxy)methyl ether. Preferably, the pR^ of the base is higher than the pK^ of the proton of the heterocycle to be deprotonated. For a listing of pK^s for various heteroaryl rings, see Fraser et ah, 1985, Can. J. Chem. 63:3505, incorporated herein by reference. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, n-butyllithium, tert-butyllithium, sec-butyllithium, phenyllithium, phenyl sodium, and o phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride. If desired, the organometallic base can be activated with a complexing agent, such as 5 N,N,N',N -tetramethylethylenediamine or hexamethylphosphoramide (1970, J. Am. Chem. Soc. 92:4664, incorporated by reference herein). Solvents suitable for synthesizing protected alcohols 17, wherein Y is a heteroaryl ring include, but are not limited to, diethyl ether; tetrahydrofuran; and hydrocarbons, such as pentane. Generally, metallation occurs alpha to the heteroatom due to the inductive effect of the heteroatom, however, modification of conditions, such as the identity of the base and solvents, order of reagent addition, reagent addition times, and reaction and addition temperatures can be modified by one of skill in the art to achieve the desired metallation position (see e.g., Joule et ah, Heterocyclic Chemistry, 3rd ed., 1995, pp. 30-42, incorporated by reference herein) Alternatively, the position of metallation can be controlled by use of a halogenated heteroaryl group, wherein 5 the halogen is located on the position of the heteroaryl ring where metallation is desired (see e.g., Joule et ah, Heterocyclic Chemistry, 3rd ed., 1995, p. 33 and Saulnier et ah, 1982, J. Org. Chem. 47:757, the two of which citations are incorporated by reference herein). Halogenated heteroaryl groups are available commercially (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or can be prepared by well-known synthetic methods (see e.g., Joule et ah, Heterocyclic Chemistry, 3rd ed., 1995, pp. 78, 85, 122, 193, 234, 261, 280, 308, incorporated by reference herein). After metallation, the reaction mixture comprising the metallated heteroaryl ring is adjusted to within a temperature range of about 0 °C to about room temperature and protected halo-alcohols 15 (diluted with a solvent or in undiluted form) are added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. After addition of protected halo-alcohols 15, the reaction mixture is stirred at a constant temperature within the range of about room temperature and about the solvent's boiling temperature and the reaction's progress can be monitored by the appropriate analytical technique, preferably thin-layer chromatography or high-performance liquid chromatography. After the reaction is substantially complete, protected alcohols 17 can be isolated by workup and purification. It is to be understood that conditions, such as the identity of protected halo-alcohol 15, the base, solvents, orders of reagent addition, times, and temperatures, can be modified by one of skill in the art to optimize the yield and selectivity. Exemplary procedures that can be used in such a transformation are described in Shirley et ah, 1995, J. Org. Chem. 20:225; Chadwick et ah, 1919, J. Chem. Soc, Perkin Trans. 1 2845: Rewcastle, 1993, Adv. Het. Chem. 56:208; Katritzky et ah, 1993, Adv. Het. Chem. 56:155; and Kessar et /., 1997, Chem. Rev. 97:721. When Y is protected alcohols 17 can be prepared from their corresponding carboxylic acid derivatives (17, wherein Y is -CO 2 H) as described in Belletire et al, 1988, Synthetic Commun. 18:2063 or from the corresponding acylchlorides (17, wherein Y is -CO-halo) as described in Skinner et ah, 1995, J. Am. Chem. Soc. 77:5440, both citations are incorporated herein by reference. The acylhalides can be prepared from the carboxylic acids by well known procedures such as those described in March, J., Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 437-438, incorporated by reference herein. When Y is wherein R 7 is as defined above, protected alcohols 17 can be prepared by first reacting protected halo-alcohols 15 with a trialkyl phosphite according to the procedure described in Kosolapoff, 1951, Org. React. 6:273 followed by reacting the derived phosphonic diester with ammonia according to the procedure described in Smith et ah, 1957, J. Org. Chem. 22:265, incorporated herein by reference. When Y is protected alcohols 17 can be prepared by reacting their sulphonic acid derivatives (i.e., 17, wherein Y is -SO 3 H ) with ammonia as described in Sianesi et ah, 1971 , Chem. Ber. 104:1880 and Campagna et al.,1994, Farmaco, Ed. Sci. 49:653, both of which citations are incorporated herein by reference). As further illustrated in Scheme 2, protected alcohols 17 can be deprotected providing alcohols 18a. The deprotection method depends on the identity of the alcohol- protecting group, see e.g., the procedures listed in Greene, T.W., Protective Groups in Organic Synthesis, 3rd edition 17-237 (1999), particularly see pages 48-49, incorporated herein by reference. One of skill in the art will readily be able to choose the appropriate deprotection procedure. When the alcohol is protected as an ether function (e.g., methoxymethyl ether), the alcohol is preferably deprotected with aqueous or alcoholic acid. Suitable deprotection reagents include, but are not limited to, aqueous hydrochloric acid, p- toluenesulfonic acid in methanol, pyridinium- -toluenesulfonate in ethanol, Amberlyst H-15 in methanol, boric acid in ethylene-glycol-monoethylether, acetic acid in a water-tetrahydrofuran mixture, aqueous hydrochloric acid is preferred. Examples of such procedures are described, respectively, in Bernady et ah, 1979, J Org. Chem. 44:1438; Miyashita et ah, 1977, J. Org. Chem. 42:3772; Johnston et ah, 1988, Synthesis 393; Bongim et ah, 1979, Synthesis 618; and Hoyer et ah, 1986, Synthesis 655; Gigg et ah, 1967, J. Chem. Soc. C, 431; and Corey et ah, 1978, J. Am. Chem. Soc. 100:1942, all of which are incorporated herein by reference. Scheme 3: Synthesis of Compounds of Formula 18b, which correspond to W (1)(2) -Z m -OH, Wherein W (1)(2) is a Lactone Group HO^ / O-PG Scheme 3 depicts the synthesis of protected lactone alcohols 22 and lactone alcohols 18b. Compounds 22 and 18b correspond to compounds of the formula W (1)(2) -Zm-OPG and W (1)(2) -Zm-OH respectively, wherein W (1)(2) is a lactone group selected from: Protected lactone alcohols 22 can be prepared from compounds of the formula 19, 20, or 21 by using well-known condensation reactions and variations of the Michael reaction. Methods for the synthesis of lactones are disclosed in Multzer in Comprehensive Organic Functional Group Transformations, A.R. Katritzky, O. Meth-Cohn and C.W. Rees, Eds. Pergamon: Oxford, 1995, vol 5, pp. 161-173, incorporated herein by reference. Mono- protected diols 19, electrophilic protected alcohols 20, and aldehydes 21 are readily available ether commercially (e.g., Aldrich Chemical Co., Milwaukee, WI) or by well known synthetic procedures. When W 1)(2) is a beta-lactone group of the formula: 3-beta-lactone 4-beta-lactone protected lactone alcohols 22 can be prepared from aldehydes 21 and electrophilic protected alcohols 20, respectively, by a one-pot-addition-lactonization according to the procedure of Masamune et ah, 1976, J. Am. Chem. Soc. 98:7874 and Danheiser et ah, 1991, J. Org. Chem. 56:1176, both of which are incorporated herein by reference. This one-pot-addition- lactonization methodology has been reviewed by Multzer in Comprehensive Organic Functional Group Transformations, A.R. Katritzky, O. Meth-Cohn and C.W. Rees, Eds. Pergamon: Oxford, 1995, vol 5, pp. 161, incorporated herein by reference When W (I) 2) is a gamma- or delta-lactone group of the formula: gamma-lactone delta-lactone protected lactone alcohols 22 can be prepared from aldehydes 21 according to well known synthetic methodology. For example, the methodology described in Masuyama et ah, 2000, J. Org. Chem. 65:494; Bisc et ah, 1978, J. Organomet. Chem. C8 160: Eaton et ah, 1947, J Org. Chem. 37: 1947;Yunker et ah, 1978, Tetrahedron Lett. 4651: Bhanot et ah, 1977, J Org. Chem. 42:1623; Ehlinger et ah, 1980, J. Am. Chem. Soc. 102:5004; and Raunio et ah, 1957, J Org. Chem. 22:570, all of which citations are incorporated herein by reference. For instance, as described in Masuyama et α/.,2000, J. Org. Chem. 65:494, aldehydes 21 can be treated with about 1 equivalent of a strong organometallic base, preferably with a K^ of about 25 or more, more preferably with a ¥^ of greater than about 35, in a suitable organic solvent to give a reaction mixture. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, n-butyllithium, tert-butyllithium, _?eo-butyllitlιium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride, preferably lithium tetramethylpiperidide. Suitable solvents include, but are not limited to, diethyl ether and tetrahydrofuran. The reaction-mixture temperature is adjusted to within the range of about 0°C to about 100°C, preferably about room temperature to about 50°C, and a halide of the formula: wherein z is 1 or 2 (diluted with a solvent or in undiluted form) is added. The reaction mixture is stirred for a period of about 2 hours to about 48 hours, preferably about 5 to about 10 hours, during which time the reaction's progress can be followed by using an appropriate analytical technique, such as thin layer chromatography or high performance liquid chromatography. When the reaction is deemed substantially complete, protected lactone alcohols 22 can be isolated by workup and purified if desired. When W (1)(2) is a gamma- or delta-lactone group of the formula: ι-lactone delta-lactone protected lactone alcohols 22 can be synthesized by deprotonating the corresponding lactone with a strong base providing the lactone enolate and reacting the enolate with electrophilic protected alcohols 20 (for a detailed discussion of enolate formation of active methylene compounds such as lactones, see House Modern Synthetic Reactions; W. A. Benjamin, Inc. Philippines 1972 pp. 492-570, and for a discussion of reaction of lactone enolates with electrophiles such as carbonyl compounds, see March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 944-945, both of which are incorporated herein by reference). Lactone-enolate formation can be accomplished by adding about 1 equivalent of a strong organometallic base, preferably with a pK, of about 25 or more, more preferably with a pK^ of greater than about 35, to a mixture comprising a suitable organic solvent and the lactone. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, /z-buxyllithium, tert-butyllithium, -fec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride, preferably lithium tetramethylpiperidide. Solvents suitable for lactone-enolate formation include, but are not limited to, diethyl ether and tetrahydrofuran. After enolate formation, the reaction-mixture temperature is adjusted to within the range of about -78 °C to about room temperature, preferably about -50°C to about 0°C, and electrophilic protected alcohols 20 (diluted with a solvent or in undiluted form) are added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. The reaction mixture is stirred for a period of about 15 minutes to about 5 hours, during which time the reaction's progress can be followed by using an appropriate analytical technique, such as thin layer chromatography or high performance liquid chromatography. When the reaction is deemed substantially complete, protected lactone alcohols 22 can be isolated by workup and purified if desired. When W (1)(2) is a lactone group of the formula: protected lactone alcohols 22 can be prepared from aldehydes 21 according to the procedure described in United States Patent No. 4,622,338, incorporated by reference herein. When W (1)(2) is a gamma- or delta-lactone group of the formula: gamma-lactone delta-lactone protected lactone alcohols 22 can be prepared according to a three step sequence. The first step comprises base-mediated reaction of electrophilic protected alcohols 20 with succinic acid esters (i.e., 9 O 2 CCH 2 CH 2 CO 2 R 9 , wherein R 9 is alkyl) or glutaric acid esters (i.e., R 9 O 2 CCH 2 CH 2 CH 2 CO 2 R 9 , wherein R 9 is alkyl) providing a diester intermediate of the formula 24: 24 wherein x is 1 or 2 depending on whether the gamma or delta lactone group is desired. The reaction can be performed by adding about 1 equivalent of a strong organometallic base, preferably with a pK-- of about 25 or more, more preferably with a pK a of greater than about 35, to a mixture comprising a suitable organic solvent and the succmic or glutaric acid ester. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, n-butyllithium, tert-butyllithium, sec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride, preferably lithium tetramethylpiperidide. Suitable solvents include, but are not limited to, diethyl ether and tetrahydrofuran. After enolate formation, the reaction-mixture temperature is adjusted to within the range of about -78 °C to about room temperature, preferably about -50 °C to about 0°C, and electrophilic protected alcohols 20 (diluted with a solvent or in undiluted form) are added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. The reaction mixture is stirred for a period of about 15 minutes to about 5 hours, during which time the reaction's progress can be followed by using an appropriate analytical technique, such as thin layer chromatography or high performance liquid chromatography. When the reaction is deemed substantially complete, the diester intermediate be isolated by workup and purified if desired. In the second step, the intermediate diester can be reduced, with a hydride reducing agent, to yield a diol of the formula 25: 25 The reduction can be performed according to the procedures referenced in March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 1214, incorporated herein by reference). Suitable reducing agents include, but are not limited to, lithium aluminum hydride, diisobutylaluminum hydride, sodium borohydride, and lithium borohydride). In the third step, the diol can be oxidatively cyclized with RuH 2 (PPh 3 ) 4 to the product protected lactone alcohols 22 according to the procedure of Yoshikawa et ah, 1986, J. Org. Chem. 51 :2034 and Yoshikawa et a .1983. Tetrahedron Lett. 26:2677, both of which citations are incorporated herein by reference. When W 1)(2) is a lactone group of the formula: protected lactone alcohols 22 can be synthesized by reacting the Grignard salts of electrophilic protected alcohols 20, where E is a halide, with 5,6-dihydro-2H-pyran-2-one, commercially available (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin), in the presence of catalytic amounts of a l-dimethylaminoacetyl)pyrolidine-2yl)methyl- diarylphosphine-copper (I) iodide complex as described in Tomioka et ah, 1995, Tetrahedron Lett. 36:4275, incorporated herein by reference. Scheme 4: Synthesis of Compounds of Formula 28 15 26 27 29, wherein n is 1 30, wherein n is 1 28, wherem n is an integer ranging from 2 to 5 10 31 intermediate 28, wherein n is 0 Scheme 4 outlines methodology for the synthesis of protected alcohols 28. Compounds 28, wherein n is an integer ranging from 1 to 5 can be prepared from compounds 15 using general synthetic strategy depicted and adapting the synthetic protocols from those discussed for Scheme 1. Next, Scheme 4 depicts the general strategy for the synthesis of compounds 28 wherein n is 0. First, Esters 31, wherein R 8 is as defined above, are synthesized by oxidation of mono-protected diols 10 in the presence of R 8 OH (see generally, March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 1196). An exemplary procedure for such an oxidation is described in Stevens et ah, 1982, Tetrahedron Lett. 23:4647 (HOC1); Sundararaman et ah, 1978, Tetrahedron Lett. 1627 (O 3 /KOH); Wilson et α/.,1982, J. Org. Chem. 47:1360 (t-BuOOH Et 3 N); and Williams et ah, 1988, Tetrahedron Lett. 29:5087 (Br 2 ), the four of which citations are incorporated by reference herein. Compounds 31 are converted to compounds 28 wherein n is 0 by adapting the synthetic procedures depicted in Scheme 1. Scheme 5: Synthesis of Compounds of Formula 18c, which correspond to compounds W (1)(2) -Z m -OH. Where W (1)(2) is C(R 1 ) R 2 )-(CH ) e C(R 3 )(R 4 )-Y 33 Scheme 5 outlines methodology for the synthesis of protected alcohols 32 and alcohols 18c, which correspond to W (1)(2) -Z m -OPG and W (1)(2) -Z m -OH, respectively, wherein W (1)(2) is C(R i )(R 2 )-(CH 2 ) c C(R 3 )(R 4 )-Y. The synthesis of starting materials 28, 30 and 33 are depicted in Scheme 4 and the synthetic methods and procedures can be adapted from those described for Scheme 2. Scheme 6: Synthesis of Compounds of Formula 18d, which correspond to compounds W 1)(2) -Z m -OH, Wherein W (1)(2) is C(RW)(CH C -V where V is a Lactone Group 16 W ( D ( 2 ) OH 7 18 where W (1)(2) is C(R 1 )(R 2 )-(CH 2 ) C -V and V is a lactone group Scheme 6 depicts the synthesis of protected lactone alcohols 34 and lactone alcohols 18d. Compounds 34 and 18d correspond to compounds of the formula, which correspond to compounds W (I)(2) -Z m -OH, Wherein W° )(2) is C(R')(R 2 )(CH2) -V and N is a Group selected from: As shown in Scheme 6, protected lactone alcohols 34 and lactone alcohols 18d can be synthesized from compounds of the formula 10, 15, or 16 by adaptation of the methods and procedures discussed above for Scheme 3. Scheme 7: Conversion of Alcohols 18 to Thiols 18e W (D(2) 0H W (ι X ^SH An Λ m 18 18e Scheme 7 depicts the synthesis of thiol 18e. Thiol 18e can be synthesized by a variety of methods. One method involves treatment of Alcohol 23 with H 2 S with a catalyst such as Al 2 O 3 ; however, this method is limited to primary alcohols as described in Lucien et al. Nouv. J. Chim. 1979, 3, 15, incorporated herein by reference. Another method involves treatment with Lawesson's reagent as described inNishio, J. Chem. Soc, Chem. Commun. 1989, 205, incorporated herein by reference. Still another method can be applied to primary, secondary, allylic, and benzylic alcohols using a fluoropyridinium salt and sodium N,N-dimethylthiocarbamate. See Hojo et a Chem. Lett. 1977, 133, 437. See also Paper, J. Org. Chem. 1988, 53, 3306, incorporated herein by reference. A general method for converting vinyl and phenyl alcohols to thiols involves initially converting the alcohol to a leaving group (e.g., a tosylate) then treating with a mercapxyl nucleophile (e.g., sodium sulfhydride, i.e., NaSH). Protected Alcohols 18 are further converted to the appropriate haloderivatives 18f, as described in Larock, R. C, Comprehensive Organic Transformation, Wiley: New York 1999, p. 689-201. The haloderivatives are isolated or subsequently treated as a crude with sodium dulfhydride or a sulfhydride equivalent (Wardell, P. The Chemistry of the Thiol Group, Patai, S., Ed.; Wiley: New York 1974, Pt. 1, p. 179-211), such as thiourea, l,8-diazabicyclo[5.4.0]undec-7-ene (Ono, N., et al. Synthesis 1980, 952), tributylhexadecylphosphonium bromide (Landini, D. Organic Synthesis Coll. Vol. 6, Wiley: New York, 1988, p. 833), or using the general procedures referenced in March, J. Advanced Organic Chemistry: Reaction Mechanisms, and Structure, Wiley: New York, 1992, 4 th ed., p. 406-407. Scheme 8: Synthesis of Disulfide Intermediates w (D(2) .SH W (l)(2). -n- Z + E — G— E 18e 35 36 m <-r + z m z m Tj , m 36 38e intermediate Scheme 8 outlines the synthesis of disulfide intermediate compounds. In the first step, compounds 36 are synthesized by reacting compounds 18e (compounds 18 a,b,c, and d are encompassed by 18e) with compounds 35 under the conditions suitable for nucleophilic substitution. The conditions and methods discussed in Scheme 1 above for the synthesis of mono-protected diols 10 from alcohols 9 can be adapted for the synthesis of compounds 36. Compounds 35, wherein E is a suitable leaving group as defined above, preferably chloride or bromide, are readily obtained commercially (e.g., Aldrich Chemical Co. Milwaukee WI) or by well known synthetic methods. Disulfide intermediate compounds are obtained by reacting compounds 36 with compounds 18e under the conditions suitable for nucleophilic substitution, hi a preferred procedure, first, a base is added to a stirred organic solution comprising thiols 18e, maintained at a constant temperature within the range of about 0°C to about 80 °C, preferably at about room temperature. Preferably, the base is added at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. The base can be added as an organic solution or in undiluted form. Preferably, the base has a pK^ of about 10 or greater. Suitable bases include, but are not limited to, hydroxides, such as sodium hydroxide, potassium hydroxide, magnesium hydroxide, calcium hydroxide, sodium carbonate, alkylmetal bases such as methyllithium, n-butyllithium, tert-butyllithium, sec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and litliium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride. The preferred base is sodium hydride. Suitable solvents include, but are not limited, to dimethyl sulfoxide, dichloromethane, ethers, and mixtures thereof, preferably tetrahydrofuran. After addition of the base, the reaction mixture is adjusted to within a temperature range of about 0°C to about room temperature and compoimds 35 are added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. Compounds 35 can be diluted in an organic solvent or added in undiluted form. The resulting reaction mixture is heated at a constant temperature within the range of about room temperature to about the solvent's boiling temperature until the reaction is substantially complete as determined by using an appropriate analytical method, preferably by thin-layer chromatography or gas chromatography. The product 36 can be isolated by workup and purification. Compound 36 thus obtained is treated with an equivalent of compound 18e in the same conditions as described above. The intermediate is separated from the reaction by the usual separation methods, recrystalization, chromatography, distillation. Scheme 9: Synthesis of Compounds of Formula I W (I)( V / S intermediate I Finally, compound I can be synthesized by oxidation of the disulfide, as depicted in Scheme 9. Thioethers can be oxidized to sulfoxides by many oxidizing agents, including but not limited to, H 2 O 2 , NaIO 4 , t-BuOCl, calcium hypochlorite, sodium chlorite, sodium hypochlorite, or dioxiranes. Care must be taken to avoid overoxidation to the sulphone, however, it is known that oxidation to the sulfoxide is much quicker and proceeds tlirough a nucleophilic sulfur mechanism, in contrast to the oxidation to the sulphone, which proceeds through an electrophilic sulfur mechanism. Thus, it is not a problem to oxidize multiple sulfides present in a single molecule to sulfoxides, while avoiding concomitant oxidation to sulphones. See, for example, The Chemistry of the Sulphones and Sulphoxides; Wiley: New York, 1988, pp. 233-378, pp. 235-255; Mikolajczyk Org. Prep. Proced. Int. 1982, 14, 45- 89; J. Chem. Soc, Perkin Trans. 2 1984, 1183; which are incorporated herein by reference. Scheme 10: Synthesis of Compounds 38 n = l-4 37 38 0 Scheme 10 illustrates the alpha disubstitution of an ester containing a terminal protected hydroxyl moiety. Compounds that contain strong electron withdrawing groups are easily converted to the corresponding enolates. These enolate ions can readily attack an electrophile resulting in alpha substitution. See Some Modern Methods of Organic Synthesis, 3 rd Ed.; Cambridge University Press: Cambridge, 1986, pp. 1-26, incorporated 5 herein by reference. The reaction is successful for primary and secondary alkyl, allylic, and benzyl groups. The use of polar aprotic solvents, e.g., dimethylformamide or dimethylsulfoxide, is preferred. Phase transfer catalysts can also be used. See Tundo et al. J. Chem. Soc, Perkin Trans. 1, 1987, 2159, which is incorporated herein by reference. Esters used as starting materials for enolate alkylations are prepared by methods Q well-known in the field and recently reviewed by J. Mueltzer in Comprehensive Organic Functional Group Transformations, A. R. Katritzky, O. Meth-Cohn and C. W. Rees, eds., Pergamon: Oxford 1995, p. 122-160. Particularly, esters with R'R 2 as a cyclopropyl group are prepared by methods summarized by T. Saegusa et al., Synthesis 1975, 291. Esters with R1R2 as a cyclopentyl group are prepared by the reductive cyclization of duodopropanes or 5 other 1,3-diiodides with acrylic esters (T. Saegusa et al., J. Org. Chem. 1974, 39, 3273). Cyclohexyl esters are conveniently prepared via Dieckmann condensation, which is particularly suitable for annulation even in sophisticated substitutions (J. Bosch et al., J. Org. Chem. 1981, 46, 1538, A. G. Pearson, J. Chem Soc, Perkins, Trans. 1 1979, 1979). Diels-ALder additions are preferred for cyclohexenoates, also for cyclohenanoates with a particular stereoselectivity. When Rl= aryl, alkylation with R2 is facilitated (E. M. Kaiser et al. In Organic Syntheses Coll. Vol. 5, Wiley: New York 1973, p. 559). Non-symmetrical dialkyl-substituted esters are prepared by esterification of the corresponding acids, available from halides R 1 R 2 CHX, via Grignard reactions (H. Gilman et al. In Organic Synthesis Coll. Vol. 1, Wiley: New York 1932, p. 361). The homologation of carboxylic acids is feasible by methods well-known in the art and summarized by the sequences: COOH → CH 2 OH - CH 2 Hal → CH 2 CN → CH 2 COOH or COOH → CH 2 OH - CH 2 Hal - CH 2 MgHal → CH 2 COOH. The transformation of an acid to the orresponding alcohol is performed using the general procedures referenced in Larock, R. C, Comprehnsive Organic Transformations, Wiley: New York, 1999, p. 1114-1123. For Halogenation of alcohols, see ibid. 689-697. The conversion of halides to caroxylic acids are described in Vogel, A. I. Textbook of Practical Organic Chemistry, Longman Scientific & Technical - Wiley: New York, 1989, p. 664-691. The conversion to a carboxylic acid with an additional carbon is achieved by treating an acyl halide with diazomethane to generate an intermediate diazo ketone, which in the presence of water and silver oxide rearranges through a ketene intermediate to a carboxylic acid with an additional carbon atom 37. If the reaction is done in an alcohol instead of water an ester is recovered. See Meier et al. Angew. Chem. Int. Ed. Eng. 1975, 14, 32-43, which is incorporated herein by reference. Alternatively, the carboxylic acid can be esterified by known techniques. The reaction can be repeated to generate methylene groups adjacent to the carboxylic acid. Scheme 11: Synthesis of Compounds of Formula 42a which correspond to Compounds W (1)(2) -fCH^ r OH. wherein W (1)(2) is CfR^fR^fCH^Y 41 Scheme 11 outlines methodology for the synthesis of protected alcohols 42a wherein Y, R 1 , R 2 , Z, and m are defined as above. Protected alcohols 42a correspond to compounds of the formula W (1)(2) -Zm-OPG, wherein W (1)( ) is C(R 1 )(R 2 )-Y. Protected alcohols 42, wherein Y comprises a -COOH group, can be synthesized by oxidizing mono-protected diols 39 with an agent suitable for oxidizing a primary alcohol to a carboxylic acid (for a discussion see M. Hudlicky, Oxidations in Organic Chemistry, ACS Monograph 186, 1990, pp. 127-130, incorporated by reference herein). Suitable oxidizing agents include, but are not limited to, pyridinium dichromate (Corey et ah, 1919, Tetrahedron Lett. 399 ); manganese dioxide (Ahrens et ah, 1967, J. Heterocych Chem. 4:625); sodium permanganate monohydrate (Menger et ah, 1981, Tetrahedron Lett. 22:1655); and potassium permanganate (Sam et ah, 1972, J. Am. Chem. Soc. 94:4024), all of which citations are incorporated by reference herein. The preferred oxidizing reagent is pyridinium dichromate. In an alternative synthetic procedure, protected alcohols 42, wherein Y comprises a -COOH group, can be synthesized by treatment of protected halo- alcohols 40, wherein X is iodo, with CO or CO 2 , as described in Bailey et ah, 1990, J Org. Chem. 55:5404 and Yanagisawa et /.,1994, J. Am. Chem. Soc. 116:6130, the two of which citations are incorporated by reference herein. Protected alcohols 42, wherein Y comprises -COOR 5 , wherein R 5 is as defined above, can be synthesized by oxidation of mono- protected diols 39 in the presence of R 5 OH (see generally, March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 1196). An exemplary procedure for such an oxidation is described in Stevens et ah, 1982, Tetrahedron Lett. 23:4647 (HOC1); Sundararaman et ah, 1978, Tetrahedron Lett. 1627 (O 3 /KOH); Wilson et ah, 1982, J Org. Chem. 47:1360 (t-BuOOH/Et 3 N); and Williams et ah, 1988, Tetrahedron Lett. 29:5087 (Br 2 ), the four of which citations are incorporated by reference herein. Preferably, protected alcohols 42, wherein Y comprises a -COOR 5 group are synthesized from the corresponding carboxylic acid (i.e. , 42, wherein Y comprises -COOH) by esterification with R 5 OH (e.g., see March, j., Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 393-394, incorporated by reference herein). In another alternative synthesis, protected alcohols 42, wherein Y comprises -COOR 5 , can be prepared from protected halo-alcohols 40 by carbonylation with transition metal complexes o (see e.g. , March, J. Advanced Organic Chemistiy; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 484-486; Urata et a/., 1991, Tetrahedron Lett. 32:36, 4733); and Ogata et ah, 1969, J Org. Chem. 3985, the three of which citations are incorporated by reference herein). Protected alcohols 42, wherein Y comprises -OCOR 5 , wherein R 5 is as defined 5 above, can be prepared by acylation of mono-protected diols 39 with a carboxylate equivalent such as an acyl halide (i.e., R 5 CO-Hal, wherein Hal is iodo, bromo, or chloro, see e.g., March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 392 and Org. Synth. Coll. Vol. m, Wiley, NY, pp. 142, 144, 167, and 187 (1955)) or an anhydride (i.e., R 5 CO-O-OCR 5 , see e.g., March, J. Advanced Organic 0 Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 392-393 and Org. Synth. Coll. Vol. HI, Wiley, NY, pp. 11, 127, 141, 169, 237, 281, 428, 432, 690, and 833 (1955), all of which citations are incorporated herein by reference). Preferably, the reaction is conducted by adding a base to a solution comprising mono-protected diols 39, a carboxylate equivalent, and an organic solvent, which solution is preferably maintained at a constant 5 temperature within the range of 0°C to about room temperature. Solvents suitable for reacting mono-protected diols 39 with a carboxylate equivalent include, but are not limited to, dichloromethane, toluene, and ether, preferably dichloromethane. Suitable bases include, but are not limited to, hydroxide sources, such as sodium hydroxide, potassium hydroxide, sodium carbonate, or potassium carbonate; or an amine such as triethylamine, 0 pyridine, or dimethylaminopyridine. The progress of the reaction can be followed by using an appropriate analytical technique, such as thin layer chromatography or high performance liquid chromatography and when substantially complete, the product can be isolated by workup and purified if desired. Protected alcohols 42, wherein Y comprises one of the following phosphate 5 ester groups wherem R 6 is defined as above, can be prepared by phosphorylation of mono-protected diols 10 according to well-known methods (for a general reviews, see Corbridge Phosphorus: An Outline of its Chemistry, Biochemistry, and Uses, Studies in Inorganic Chemistry, 3rd ed., pp. 357-395 (1985); Ramirez et ah, 1978, Ace Chem. Res. 11:239; and Kalckare Biological Phosphorylations, Prentice-Hall, New York (1969); J. B. Sweeny in Comprehensive 0 Organic Functional Group Transformations, A.R. Katritzky, O. Meth-Cohn and C.W. Rees, Eds. Pergamon: Oxford, 1995, vol 2, pp. 104-109, the four of which are incorporated herein by reference). Protected alcohols 42 wherein Y comprises a monophosphate group of the formula: wherein R 6 is defined as above, can be prepared by treatment of mono-protected diol 39 with phosphorous oxychloride in a suitable solvent, such as xylene or toluene, at a constant o temperature within the range of about 100°C to about 150°C for about 2 hours to about 24 hours. After the reaction is deemed substantially complete, by using an appropriate analytical method, the reaction mixture is hydrolyzed with R 6 -OH. Suitable procedures are referenced in Houben-Weyl, Methoden der Organische Chemie, Georg Thieme Verlag Stuttgart 1964, vol. Xπ/2, pp. 143-210 and 872-879, incorporated by reference herein. 5 Alternatively, when both R 6 are hydrogen, can be synthesized by reacting mono-protected diols 10 with silyl polyphosphate (Okamoto et ah, 1985, Bull Chem. Soc. Jpn. 58:3393, incorporated herein by reference) or by hydrogenolysis of their benzyl or phenyl esters (Chen et ah, 1998, J. Org. Chem. 63:6511, incorporated herein by reference). In another alternative procedure, when R 6 is (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl, the 0 monophosphate esters can be prepared by reacting mono-protected diols 39 with appropriately substituted phophoramidites followed by oxidation of the intermediate with rø-chloroperbenzoic acid (Yu et ah, 1988, Tetrahedron Lett. 29:979, incorporated herein by reference) or by reacting mono-protected diols 39 with dialkyl or diaryl substituted phosphorochloridates (Pop, et /, 1997, Org. Prep, and Proc. Int. 29:341, incorporated 5 herein by reference). The phosphoramidites are commercially available (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or readily prepared according to literature procedures (see e.g., Uhlmann et al.1986, Tetrahedron Lett. 27:1023 and Tanaka et ah, 1988, Tetrahedron Lett. 29:199, both of which are incorporated herein by reference). The phosphorochloridates are also commercially available (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or prepared according to literature methods (e.g., Gajda et al, 1995, Synthesis 25:4099. hi still another alternative synthesis, protected alcohols 42, wherein Y comprises a monophosphate group and R 6 is alkyl or aryl, can be prepared by reacting IP + (OR 6 ) 3 with mono-protected diols 39 according to the procedure described in Stowell et ah, 1995, Tetrahedron Lett. 36:11, 1825 or by alkylation of protected halo alcohols 40 with the appropriate dialkyl or diaryl phosphates (see e.g., Okamoto, 1985, Bull Chem. Soc. Jpn. 58:3393, incorporated herein by reference). Protected alcohols 42 wherein Y comprises a diphosphate group of the formula wherein R 6 is defined as above, can be synthesized by reacting the above-discussed monophosphates of the formula: with a phosphate of the formula (commercially available, e.g., Aldrich Chemical Co., Milwaukee, Wisconsin), in the presence of carbodiimide such as dicyclohexylcarbodumide, as described in Houben-Weyl, Methoden der Organische Chemie, Georg Thieme Nerlag Stuttgart 1964, vol. XII/2, pp. 881-885. In the same fashion, protected alcohols 42, wherein Y comprises a triphosphate group of the formula: can be synthesized by reacting the above-discussed diphosphate protected alcohols, of the formula: with a phosphate of the formula: as described above. Alternatively, when R 6 is H, protected alcohols 42 wherein Y comprises the triphosphate group, can be prepared by reacting mono-protected diols 39 with salicyl phosphorochloridite and then pyrophosphate and subsequent cleavage of the adduct thus obtained with iodine in pyridine as described in Ludwig et ah, 1989, J. Org. Chem. 54:631 , incorporated herein by reference. Protected alcohols 42, wherein Y is -SO 3 H or a heterocyclic group selected from the group consisting of: can be prepared by halide displacement from protected halo-alcohols 40. Thus, when Y is -SO 3 H, protected alcohols 42 can by synthesized by reacting protected halo-alcohols 40 with sodium sulfite as described in Gilbert Sulfonation and Related Reactions; Wiley: New York, 1965, pp. 136-148 and pp. 161-163; Org. Synth. Coll. Vol. II, Wiley, NY, 558, 564 (1943); and Org. Synth. Coll. Vol. IV, Wiley, NY, 529 (1963), all three of which are incorporated herein by reference. When Y is one of the above-mentioned heterocycles, protected alcohols 42 can be prepared by reacting protected halo-alcohols 40 with the corresponding heterocycle in the presence of a base. The heterocycles are available commercially (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or prepared by well- known synthetic methods (see the procedures described in Ware, 1950, Chem. Rev. 46:403- 470, incorporated herein by reference). Preferably, the reaction is conducted by stirring a mixture comprising 40, the heterocycle, and a solvent at a constant temperature within the range of about room temperature to about 100°C, preferably within the range of about 50°C to about 70 °C for about 10 to about 48 hours. Suitable bases include hydroxide bases such as sodium hydroxide, potassium hydroxide, sodium carbonate, or potassium carbonate. Preferably, the solvent used in forming protected alcohols 42 is selected from dimethylformamide; formamide; dimethyl sulfoxide; alcohols, such as methanol or ethanol; and mixtures thereof. The progress of the reaction can be followed by using an appropriate analytical technique, such as thin layer chromatography or high performance liquid chromatography and when substantially complete, the product can be isolated by workup and purified if desired. Protected alcohols 42, wherein Y is a heteroaryl ring selected from can be prepared by metallating the suitable heteroaryl ring then reacting the resulting metallated heteroaryl ring with protected halo-alcohols 40 (for a review, see Katritzky Handbook of Heterocyclic Chemistry, Pergamon Press: Oxford 1985). The heteroaryl rings are available commercially or prepared by well-known synthetic methods (see e.g., Joule et ah, Heterocyclic Chemistry, 3rd ed., 1995; De Sarlo et ah, 1971, J. Chem. Soc. (C) 86; Oster et al., 1983, J. Org. Chem. 48:4307; Iwai et ah, 1966, Chem. Pharm. Bull. 14:1211; and United States Patent No. 3,152,148, all of which citations are incorporated herein by reference). As used herein, the term "metallating" means the forming of a carbon-metal bond, which bond may be substantially ionic in character. Metallation can be accomplished by adding about 2 equivalents of strong organometallic base, preferably with a p ; of about 25 or more, more preferably with a pK, of greater than about 35, to a mixture comprising a suitable organic solvent and the heterocycle. Two equivalents of base are required: one equivalent of the base deprotonates the -OH group or the -NH group, and the second equivalent metallates the heteroaryl ring. Alternatively, the hydroxy group of the heteroaryl ring can be protected with a base-stable, acid-labile protecting group as described in Greene, T.W., Protective Groups in Organic Synthesis, 3rd edition 17-237 (1999), incorporated herein by reference. Where the hydroxy group is protected, only one equivalent of base is required. Examples of suitable base-stable, acid-labile hydroxyl-protecting groups, include but are not limited to, ethers, such as methyl, methoxy methyl, methylthiomethyl, methoxyethoxymethyl, bts(2-chloroethoxy)methyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahyrofuranyl, tetrahydrothiofuranyl, 1-ethoxyethyl, 1-methyl-l- methoxyethyl, t-butyl, allyl, benzyl, o-nitrobenzyl, triphenylmethyl, α- naphthyldiphenylmethyl, -methoxyphenyldiphenylmethyl, 9-(9-phenyl- 10-oxo)anthranyl, trimethylsilyl, isopropyldimethylsilyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, tribenzylsilyl, triisopropylsilyl; and esters, such as pivaloate, adamantoate, and 2,4,6- trimethylbenzoate. Ethers are preferred, particularly straight chain ethers, such as methyl ether, methoxymethyl ether, methylthiomethyl ether, methoxyethoxymethyl ether, bis(2- chloroethoxy)methyl ether. Preferably, the pK a of the base is higher than the pK a of the proton of the heterocycle to be deprotonated. For a listing of pK- j S for various heteroaryl rings, see Fraser et ah, 1985, Can. J. Chem. 63:3505, incorporated herein by reference. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, n-butyllithium, tert-butyllithium, sec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride. If desired, the organometallic base can be activated with a complexing agent, such as N,N,N',N -tetramethylethylenediamine or hexamethylphosphoramide (1970, J. Am. Chem. Soc. 92:4664, incorporated by reference herein). Solvents suitable for synthesizing protected alcohols 42, wherein Y is a heteroaryl ring include, but are not limited to, diethyl ether; tetrahydrofuran; and hydrocarbons, such as pentane. Generally, metallation occurs alpha to the heteroatom due to the inductive effect of the heteroatom, however, modification of conditions, such as the identity of the base and solvents, order of reagent addition, reagent addition times, and reaction and addition temperatures can be modified by one of skill in the art to achieve the desired metallation position (see e.g., Joule et ah, Heterocyclic Chemistry, 3rd ed., 1995, pp. 30-42, incorporated by reference herein) Alternatively, the position of metallation can be controlled by use of a halogenated heteroaryl group, wherein the halogen is located on the position of the heteroaryl ring where metallation is desired (see e.g., Joule et ah, Heterocyclic Chemistry, 3rd ed., 1995, p. 33 and Saulnier et ah, 1982, J. Org. Chem. 47:757, the two of which citations are incorporated by reference herein). Halogenated heteroaryl groups are available commercially (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin) or can be prepared by well-known synthetic methods (see e.g., Joule et ah, Heterocyclic Chemistry, 3rd ed., 1995, pp. 78, 85, 122, 193, 234, 261, 280, 308, incorporated by reference herein). After metallation, the reaction mixture comprising the metallated heteroaryl ring is adjusted to within a temperature range of about 0°C to about room temperature and protected halo-alcohols 40 (diluted with a solvent or in undiluted form) are added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. After addition of protected halo-alcohols 40, the reaction mixture is stirred at a constant temperature within the range of about room temperature and about the solvent's boiling temperature and the reaction's progress can be monitored by the appropriate analytical technique, preferably thin-layer chromatography or high-performance liquid chromatography. After the reaction is substantially complete, protected alcohols 42 can be isolated by workup and purification. It is to be understood that conditions, such as the identity of protected halo-alcohol 40, the base, solvents, orders of reagent addition, times, and temperatures, can be modified by one of skill in the art to optimize the yield and selectivity. Exemplary procedures that can be used in such a transformation are described in Shirley et ah, 1995, J. Org. Chem. 20:225; Chadwick et ah, 1979, J. Chem. Soc, Perkin Trans. 1 2845: Rewcasfle, 1993, Adv. Het. Chem. 56:208; Katritzky et ah, 1993, Adv. Het. Chem. 56:155; and Kessar et α/.,1997, Chem. Rev. 97:721. When Y is protected alcohols 42 can be prepared from their corresponding carboxylic acid derivatives (42, wherein Y is -CO 2 H) as described in Belletire et al, 1988, Synthetic Commun. 18:2063 or from the corresponding acylchlorides (42, wherein Y is -CO-halo) as described in Skinner et ah, 1995, J. Am. Chem. Soc. 77:5440, both citations are incorporated herein by reference. The acylhalides can be prepared from the carboxylic acids by well known procedures such as those described in March, J., Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 437-438, incorporated by reference herein. When Y is wherein R 7 is as defined above, protected alcohols 42 can be prepared by first reacting protected halo-alcohols 40 with a trialkyl phosphite according to the procedure described in Kosolapoff, 1951, Org. React. 6:273 followed by reacting the derived phosphonic diester with ammonia according to the procedure described in Smith et ah, 1951, J. Org. Chem. 22:265, incorporated herein by reference. When Y is ! -^^S — NH 2 II o protected alcohols 42 can be prepared by reacting their sulphonic acid derivatives (i.e., 42, wherein Y is -SO 3 H ) with ammonia as described in Sianesi et ah, 1971, Chem. Ber. 104:1880 and Campagna et ah, 1994, Farmaco, Ed. Sci. 49:653, both of which citations are incorporated herein by reference). Scheme 12: Synthesis of Compounds of Formula 46 which correspond to Compounds W 1)(2 -(CHχθH. wherein W 1)(2) is C(R^(R 2 CH 7 r Lactone 45 As further illustrated in Scheme 12, protected alcohols 42 can be deprotected providing alcohols 42 a. The deprotection method depends on the identity of the alcohol- protecting group, see e.g., the procedures listed in Greene, T.W., Protective Groups in Organic Synthesis, 3rd edition 17-237 (1999), particularly see pages 48-49, incorporated herein by reference. One of skill in the art will readily be able to choose the appropriate deprotection procedure. When the alcohol is protected as an ether function (e.g., methoxymethyl ether), the alcohol is preferably deprotected with aqueous or alcoholic acid. Suitable deprotection reagents include, but are not limited to, aqueous hydrochloric acid, p- toluenesulfonic acid in methanol, pyridimum-/?-toluenesulfonate in ethanol, Amberlyst H-15 in methanol, boric acid in ethylene-glycol-monoethylether, acetic acid in a water-tetrahydrofuran mixture, aqueous hydrochloric acid is preferred. Examples of such procedures are described, respectively, in Bernady et ah, 1979, J. Org. Chem. 44:1438; Miyashita et ah, 1977, J Org. Chem. 42:3772; Johnston et ah, 1988, Synthesis 393; Bongini et ah, 1979, Synthesis 618; and Hoyer et ah, 1986, Synthesis 655; Gigg et ah, 1967, J. Chem. Soc. C, 431; and Corey et ah, 1978, J. Am. Chem. Soc. 100:1942, all of which are Q incorporated herein by reference. Scheme 12 depicts the synthesis of protected lactone alcohols 46 and lactone. Compound 46 corresponds to compounds of the formula W (1)(2) -Zm-OPG and , wherein (i)(2) j s a lac one group selected from: Protected lactone alcohols 46 can be prepared from compounds of the formula 43, 45, or 44 by using well-known condensation reactions and variations of the Michael reaction. Methods for the synthesis of lactones are disclosed in Multzer in Comprehensive Organic Functional Group Transformations, A.R. Katritzky, O. Meth-Cohn and C.W. Rees, Eds. 0 Pergamon: Oxford, 1995, vol 5, pp. 161-173, incorporated herein by reference. Mono- protected diols 43, electrophilic protected alcohols 44, and aldehydes 45 are readily available either commercially (e.g., Aldrich Chemical Co., Milwaukee, WI) or by well known synthetic procedures. When W (1 (2 is a beta-lactone group of the formula: 5 3-beta-lactone 4-beta-lactone protected lactone alcohols 46 can be prepared from aldehydes 45 and electrophilic protected alcohols 44, respectively, by a one-pot addition-lactonization according to the procedure of Masamune et ah, 1976, J Am. Chem. Soc. 98:7874 and Danheiser et ah, 1991, J Org. Chem. 56:1176, both of which are incorporated herein by reference. This one-pot addition- lactonization methodology has been reviewed by Multzer in Comprehensive Organic Functional Group Transformations, A.R. Katritzky, O. Meth-Cohn and C.W. Rees, Eds. Pergamon: Oxford, 1995, vol 5, pp. 161, incorporated herein by reference When W (1)(2) is a gamma- or delta-lactone group of the formula: gamma-lactone delta-lactone protected lactone alcohols 46 can be prepared from aldehydes 45 according to well known synthetic methodology. For example, the methodology described in Masuyama et ah, 2000, J Org. Chem. 65:494; Eisch t /., 1978, J. Organo. Met. Chem. C8 160; Eaton et ah, 1947, J Org. Chem. 37:1947; Yunker et ah, 1978, Tetrahedron Lett. 4651: Bhanot et ah, 1977, J Org. Chem. 42:1623; Ehlinger et ah, 1980, J. Am. Chem. Soc. 102:5004; and Raunio et ah, 1951, J. Org. Chem. 22:570, all of which citations are incorporated herein by reference. For instance, as described in Masuyama et α/.,2000, J Org. Chem. 65:494, aldehydes 45 can be treated with about 1 equivalent of a strong organometallic base, preferably with a pK a of about 25 or more, more preferably with a p , of greater than about 35, in a suitable organic solvent to give a reaction mixture. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, «-butyllithium, tert-butyllithium, sec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride, preferably lithium tetramethylpiperidide. Suitable solvents include, but are not limited to, diethyl ether and tetrahydr furan. The reaction-mixture ' I temperature is adjusted to within the range of about 0°C to about 100°C, preferably about room temperature to about 50 °C, and a halide of the formula: wherein z is 1 or 2 (diluted with a solvent or in undiluted form) is added. The reaction mixture is stirred for a period of about 2 hours to about 48 hours, preferably about 5 to about 10 hours, during which time the reaction's progress can be followed by using an Q appropriate analytical technique, such as thin layer cliromatography or high performance liquid cliromatography. When the reaction is deemed substantially complete, protected lactone alcohols 46 can be isolated by workup and purified if desired. When W (1)(2) is a gamma- or delta-lactone group of the formula: gamma-lactone delta-lactone 0 protected lactone alcohols 46 can be synthesized by deprotonating the corresponding lactone with a strong base providing the lactone enolate and reacting the enolate with electrophilic protected alcohols 44 (for a detailed discussion of enolate formation of active methylene compounds such as lactones, see House Modern Synthetic Reactions; W. A. Benjamin, hie. Philippines 1972 pp. 492-570, and for a discussion of reaction of lactone enolates with 5 electrophiles such as carbonyl compounds, see March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 944-945, both of which are incorporated herein by reference). Lactone-enolate formation can be accomplished by adding about 1 equivalent of a strong organometallic base, preferably with a pK-- of about 25 or more, more preferably with a Kg of greater than about 35, to a mixture comprising a 0 suitable organic solvent and the lactone. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, «-butyllithium, tert-butyllithium, seo-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium 5 hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride, preferably lithium tetramethylpiperidide. Solvents suitable for lactone-enolate formation include, but are not limited to, diethyl ether and tetrahydrofuran. After enolate formation, the reaction-mixture temperature is adjusted to within the range of about -78°C to about room temperature, preferably about -50°C to about 0°C, and electropliilic protected alcohols 44 (diluted with a solvent or in undiluted form) are added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. The reaction mixture is stirred for a period of about 15 minutes to about 5 hours, during which time the reaction's progress can be followed by using an appropriate analytical technique, such as thin layer chromatography or high performance liquid chromatography. When the reaction is deemed substantially complete, protected lactone alcohols 46 can be isolated by workup and purified if desired. When W (ι:)(2) is a lactone group of the formula: protected lactone alcohols 46 can be prepared from aldehydes 45 according to the procedure described in United States Patent No. 4,622,338, incorporated by reference herein. When W (1)(2) is a gamma- or delta-lactone group of the formula: gamma-lactone delta-lactone protected lactone alcohols 46 can be prepared according to a three step sequence. The first step comprises base-mediated reaction of electropliilic protected alcohols 44 with succinic acid esters (i.e., R 9 O 2 CCH 2 CH 2 CO 2 R 9 , wherein R 9 is alkyl) or glutaric acid esters (i.e., R 9 O 2 CCH 2 CH 2 CH 2 CO 2 R 9 , wherein R 9 is alkyl) providing a diester intermediate of the formula 44i: 44ii wherein x is 1 or 2 depending on whether the gamma or delta lactone group is desired. The reaction can be performed by adding about 1 equivalent of a strong organometallic base, preferably with a pK a of about 25 or more, more preferably with a pK, of greater than about 35, to a mixture comprising a suitable organic solvent and the succinic or glutaric acid ester. Suitable bases include, but are not limited to, alkylmetal bases such as methyllithium, «-butyllithium, tert-butyllithium, sec-butyllithium, phenyllithium, phenyl sodium, and phenyl potassium; metal amide bases such as lithium amide, sodium amide, potassium amide, lithium tetramethylpiperidide, lithium diisopropylamide, lithium diethylamide, lithium dicyclohexylamide, sodium hexamethyldisilazide, and lithium hexamethyldisilazide; and hydride bases such as sodium hydride and potassium hydride, preferably lithium tetramethylpiperidide. Suitable solvents include, but are not limited to, diethyl ether and tetrahydrofuran. After enolate formation, the reaction-mixture temperature Q is adjusted to within the range of about -78 °C to about room temperature, preferably about -50 °C to about 0°C, and electrophilic protected alcohols 44 (diluted with a solvent or in undiluted form) are added, preferably at a rate such that the reaction-mixture temperature remains within about one to two degrees of the initial reaction-mixture temperature. The reaction mixture is stirred for a period of about 15 minutes to about 5 hours, during which time the reaction's progress can be followed by using an appropriate analytical technique, such as thin layer cliromatography or high performance liquid chromatography. When the reaction is deemed substantially complete, the di-ester intermediate can be isolated by workup and purified if desired. In the second step, the intermediate diester can be reduced, with a hydride reducing agent, to yield a diol: 0 The reduction can be performed according to the procedures referenced in March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, p. 1214, incorporated herein by reference. Suitable reducing agents include, but are not limited to, lithium aluminum hydride, diisobutylaluminum hydride, sodium borohydride, and lithium borohydride). hi the third step, the diol can be oxidatively cyclized with 0 RuH 2 (PPh 3 ) 4 to the product protected lactone alcohols 46 according to the procedure of Yoshikawa et ah, 1986, J. Org. Chem. 51:2034 and Yoshikawa et ah, 1983, Tetrahedron Lett. 26:2677, both of which citations are incorporated herein by reference. When W (1)(2) is a lactone group of the formula: 5 protected lactone alcohols 46 can be synthesized by reacting the Grignard salts of electrophilic protected alcohols 44, where E is a halide, with 5,6-dihydro-2H-pyran-2-one, commercially available (e.g., Aldrich Chemical Co., Milwaukee, Wisconsin), in the presence of catalytic amounts of a l-dimethylaminoacetyl)pyrolidine-2yl)methyl- diarylphosphine-copper (I) iodide complex as described in Tomioka et ah, 1995, o Tetrahedron Lett. 36:4275, incorporated herein by reference. Scheme 13: Synthesis of Compounds of Formula II, Ila 5 47 48 0 49 50 0 Intermediate Scheme 13 illustrates the synthesis of sulfoxide II. The ester 47 is initially converted to the desired group W 10 , which is defined above. Compound 48 is then treated with sodium sulfhydride to form a thiol from the alkyl halide. See Wardell, in Patai The Chemistry of the Thiol Group, pt.l; Wiley: New York, 1974, pp. 179-211. The thiol is then condensed with halide 48 to form sulfide 52. The ester in 52 is then converted to the desired group W u , which is defined above, to afford the intermediate, which can be oxidized by oxidants as described above for Scheme 9 to afford II. Compounds of formula Ila can be formed by the same method where each occurrence of R 1 is phenyl. Scheme 14: Synthesis of Compounds III, Ilia Illi selective placement of the double bond(s) in the ring. Scheme 14 depicts the synthesis of compounds III, that is, compounds III where a double bond is present in the ring. In the first step, the appropriate heterocycle is hthiated with an alkyl lithium base (alkyl-Li, e.g., butyl lithium) by well known synthetic methods (for a review, see Katritzky Handbook of Heterocyclic Chemistry, Pergamon Press: Oxford 1985). Thiopyranose-type heterocycles are exclusively lithiated in the 2-position to provide compounds 66, which in turn are then reacted with electropliiles 67 to produce derivatives 69 (Benkeser, R. A. et ah, J. Amer. Chem. Soc. 1948, 70, 1780; Ramanathan, N. et ah, J. Amer. Chem. Soc 1962, 27, 1216;Chadwick, D. J. et ah, J. Chem. Soc. Perkin 1 1977, 887; Feringa, B. L. et ah, Synthesis 1988, 316, all of which citations are incorporated herein by reference). Lithiation to the literature methods, by reacting the heterocycles with alkyl- lithium derivatives such as methyl-lithium, n-,s-, or t-butyl-lithium in solvents such as ether, glyme or tetrahydrofuran, preferably ether. Preferably, ligands, such as TMEDA, DMPU or HMPA or another strong base, such as potassium t-butoxide are included in the reaction . medium. Preferably, the reaction temperature is between -40 °C to +60 °C, and the reaction time is about 1 to 5 fir. The heterocycles are available commercially or prepared by well- known synthetic methods. Next, in a similar fashion, 70 is condensed with 69 to give Illi, wherein each ring has two double bonds. The reactions are performed under similar conditions for substituted heterocycles (for a review on lithiation of 2-substituted furans and thiophenes see Comprehensive Heterocyclic Chemistry; Katritzky, A. R.; Rees, W. C. Eds.; Pergamon Press: Oxford, 1986; Vol.3, p 771). After the formation of the metallated heterocylces, they are in situ reacted with electrophiles (e.g., 70) at temperatures between -40 °C to +60 °C, for a reaction time of 1 hr to 5 days. The ring double bonds can be selectively reduced or otherwise manipulated by well known synthetic methods to give compounds Illi having only one selectively-placed double bond (i.e., the double bond can be positioned in the desired location within the ring), for example, the methods disclosed in March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, pp. 771-780, incorporated herein by reference. Finally, intermediate Illi can be oxidized to the sulfoxide using oxidants as described above for Scheme 9 to afford Ilia. 4.3. Therapeutic Uses of Compounds or Compositions of the Invention In accordance with the invention, a compound of the invention or a composition of the invention, comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent, is administered to a patient, preferably a human, with or at risk of cardiovascular disease, a dyslipidemia, a dyslipoproteinemia, a disorder of glucose metabolism, Alzheimer's Disease, Syndrome X, a PPAR-associated disorder, septicemia, a thrombotic disorder, obesity, pancreatitis, hypertension, a renal disease, cancer, inflammation, or impotence. In one embodiment, "treatment" or "treating" refers to an amelioration of a disease or disorder, or at least one discernible symptom thereof, hi yet another embodiment, "treatment" or "treating" refers to inhibiting the progression of a disease or disorder, either physically, e.g., stabilization of a discernible symptom, physiologically, e.g., stabilization of a physical parameter, or both. In certain embodiments, the compounds of the invention or the compositions of the invention are administered to a patient, preferably a human, as a preventative measure against such diseases. As used herein, "prevention" or "preventing" refers to a reduction of the risk of acquiring a given disease or disorder. In another embodiment, "prevention" or "preventing" refers to delaying the onset of a disease or disorder. J-n a preferred mode of the embodiment, the compounds and compositions of the present invention are administered as a preventative measure to a patient, preferably a human, having a genetic predisposition to a cardiovascular disease, a dyslipidemia, a dyslipoproteinemia, a disorder of glucose Q metabolism, Alzheimer's Disease, Syndrome X, a PPAR-associated disorder, septicemia, a thrombotic disorder, obesity, pancreatitis, hypertension, a renal disease, cancer, inflammation, or impotence. Examples of such genetic predispositions include but are not limited to the ε4 allele of apolipoprotein E, which increases the likelihood of Alzheimer's Disease; a loss of function or null mutation in the lipoprotein lipase gene coding region or promoter (e.g. , mutations in the coding regions resulting in the substitutions D9N and N291S; for a review of genetic mutations in the lipoprotein lipase gene that increase the risk of cardiovascular diseases, dyslipidemias and dyslipoproteinemias, see Hayden and Ma, 1992, Mol. Cell Biochem. 113:171-176): and familial combined hyperlipidemia and familial hypercholesterolemia . hi another preferred mode of the embodiment, the compounds of the invention or compositions of the invention are administered as a preventative measure to a patient having a non-genetic predisposition to a cardiovascular disease, a dyslipidemia, a dyslipoproteinemia, a disorder of glucose metabolism, Alzheimer's Disease, Syndrome X, a PPAR-associated disorder, septicemia, a thrombotic disorder, obesity, pancreatitis, 5 hypertension, a renal disease, cancer, inflammation, or impotence. Examples of such non- genetic predispositions include but are not limited to cardiac bypass surgery and percutaneous transluminal coronary angioplasty, which often lead to restenosis, an accelerated form of atherosclerosis; diabetes in women, which often leads to polycystic ovarian disease; and cardiovascular disease, which often leads to impotence. Accordingly, Q the compounds and compositions of the invention may be used for the prevention of one disease or disorder and concurrently treating another (e.g., prevention of polycystic ovarian disease while treating diabetes; prevention of impotence while treating a cardiovascular disease). 5 4.3.1. Cardiovascular Diseases for Treatment or Prevention The present invention provides methods for the treatment or prevention of a cardiovascular disease, comprising administering to a patient a therapeutically effective amount of a compound or a composition comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent. As used herein, the term "cardiovascular diseases" refers to diseases of the heart and circulatory system. These diseases are often associated with dyslipoproteinemias and/or dyslipidemias. Cardiovascular diseases which the compounds and compositions of the present invention are useful for preventing or treating include but are not limited to arteriosclerosis; atherosclerosis; stroke; ischemia; endothelium dysfunctions, in particular those dysfunctions Q affecting blood vessel elasticity; peripheral vascular disease; coronary heart disease; myocardial infarcation; cerebral infarction and restenosis. 4.3.2. Dyslipidemias for Treatment or Prevention The present invention provides methods for the treatment or prevention of a 5 dyslipidemia comprising administering to a patient a therapeutically effective amount of a compound or a composition comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent. As used herein, the term "dyslipidemias" refers to disorders that lead to or are manifested by aberrant levels of circulating lipids. To the extent that levels of lipids in the 0 blood are too high, the compounds and compositions of the invention are administered to a patient to restore normal levels. Normal levels of lipids are reported in medical treatises known to those of skill in the art. For example, recommended blood levels of LDL, HDL, free triglycerides and others parameters relating to lipid metabolism can be found at the web site of the American Heart Association and that of the National Cholesterol Education 5 Program of the National Heart, Lung and Blood Institute. (Your Total Cholesterol Level [online], 2000, [retrieved on 2001-10-11]. Retrieved from the hιternet:<URL: http://www.americanheart.org/cholesterol/about_level.html>. What You Need to Know [online], 2000 [retrieved on 2001-10-11]. Retrieved from the hιternet:<URL: http://www.nhlbi.nih.gov/health/public/heart7chol/hbc_what.htm>). At the present time, the Q recommended level of HDL cholesterol in the blood is above 35 mg/dL; the recommended level of LDL cholesterol in the blood is below 130 mg/dL; the recommended LDL:HDL cholesterol ratio in the blood is below 5:1, ideally 3.5:1; and the recommended level of free triglycerides in the blood is less than 200 mg/dL. Dyslipidemias which the compounds and compositions of the present invention are 5 useful for preventing or treating include but are not limited to hyperlipidemia and low blood levels of high density lipoprotein (HDL) cholesterol. In certain embodiments, the hyperlipidemia for prevention or treatment by the compounds of the present invention is familial hypercholesterolemia; familial combined hyperlipidemia; reduced or deficient lipoprotein lipase levels or activity, including reductions or deficiencies resulting from lipoprotein lipase mutations; hypertriglyceridemia; hypercholesterolemia; high blood levels of ketone bodies (e.g. β-OH butyric acid); high blood levels of Lρ(a) cholesterol; high blood levels of low density lipoprotein (LDL) cholesterol; high blood levels of very low density lipoprotein (NLDL) cholesterol and high blood levels of non-esterified fatty acids. The present invention further provides methods for altering lipid metabolism in a patient, e.g., reducing LDL in the blood of a patient, reducing free triglycerides in the blood of a patient, increasing the ratio of HDL to LDL in the blood of a patient, and inhibiting saponified and/or non-saponified fatty acid synthesis, said methods comprising administering to the patient a compound or a composition comprising a compound of the invention in an amount effective alter lipid metabolism. 4.3.3. Dyslipoproteinemias for Treatment or Prevention The present invention provides methods for the treatment or prevention of a dyslipoproteinemia comprising administering to a patient a therapeutically effective amount of a compound or a composition comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent. As used herein, the term "dyslipoproteinemias" refers to disorders that lead to or are 0 manifested by aberrant levels of circulating lipoproteins. To the extent that levels of lipoproteins in the blood are too high, the compounds and compositions of the invention are administered to a patient to restore normal levels. Conversely, to the extent that levels of lipoproteins in the blood are too low, the compoimds and compositions of the invention are administered to a patient to restore normal levels. Normal levels of lipoproteins are reported 5 in medical treatises known to those of skill in the art. Dyslipoproteinemias which the compounds and compositions of the present invention are useful for preventing or treating include but are not limited to high blood levels of LDL; high blood levels of apolipoprotein B (apo B); high blood levels of Lp(a); high blood levels of apo(a); high blood levels of NLDL; low blood levels of HDL; reduced Q or deficient lipoprotein lipase levels or activity, including reductions or deficiencies resulting from lipoprotein lipase mutations; hypoalphalipoproteinemia; lipoprotein abnormalities associated with diabetes; lipoprotein abnormalities associated with obesity; lipoprotein abnormalities associated with Alzheimer's Disease; and familial combined hyperlipidemia. 5 The present invention further provides methods for reducing apo C-JJ levels in the blood of a patient; reducing apo C-I1T levels in the blood of a patient; elevating the levels of HDL associated proteins, including but not limited to apo A-I, apo A-JJ, apo A-IV and apo E in the blood of a patient; elevating the levels of apo E in the blood of a patient, and promoting clearance of triglycerides from the blood of a patient, said methods comprising administering to the patient a compound or a composition comprising a compound of the invention in an amount effective to bring about said reduction, elevation or promotion, respectively. 4.3.4. Glucose Metabolism Disorders for Treatment or Prevention The present invention provides methods for the treatment or prevention of a glucose metabolism disorder, comprising administering to a patient a therapeutically effective Q amount of a compound or a composition comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent. As used herein, the term "glucose metabolism disorders" refers to disorders that lead to or are manifested by aberrant glucose storage and/or utilization. To the extent that indicia of glucose metabolism (i.e., blood insulin, blood glucose) are too high, the compounds and compositions of the 5 invention are administered to a patient to restore normal levels. Conversely, to the extent that indicia of glucose metabolism are too low, the compounds and compositions of the invention are administered to a patient to restore normal levels. Normal indicia of glucose metabolism are reported in medical treatises known to those of skill in the art. Glucose metabolism disorders which the compounds and compositions of the 0 present invention are useful for preventing or treating include but are not limited to impaired glucose tolerance; insulin resistance; insulin resistance related breast, colon or prostate cancer; diabetes, including but not limited to non-insulin dependent diabetes mellitus (NTDDM), insulin dependent diabetes mellitus (IDDM), gestational diabetes mellitus (GDM), and maturity onset diabetes of the young (MODY); pancreatitis; 5 hypertension; polycystic ovarian disease; and high levels of blood insulin and/or glucose. The present invention further provides methods for altering glucose metabolism in a patient, for example to increase insulin sensitivity and or oxygen consumption of a patient, said methods comprising administering to the patient a compound or a composition comprising a compound of the invention in an amount effective to alter glucose metabolism. 0 4.3.5. PPAR Associated Disorders for Treatment or Prevention The present invention provides methods for the treatment or prevention of a PPAR- associated disorder, comprising administering to a patient a therapeutically effective amount of a compound or a composition comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent. As used herein, "treatment or prevention of PPAR associated disorders" encompasses treatment or prevention of rheumatoid arthritis; multiple sclerosis; psoriasis; inflammatory bowel diseases; breast; colon or prostate cancer; low levels of blood HDL; low levels of blood, lymph and/or cerebrospinal fluid apo E; low blood, lymph and/or cerebrospinal fluid levels of apo A-I; high levels of blood NLDL; high levels of blood LDL; high levels of blood triglyceride; high levels of blood apo B; high levels of blood apo C-m and reduced ratio of post-heparin hepatic lipase to lipoprotein lipase activity. HDL may be elevated in lymph and/or cerebral fluid. 4.3.6. Renal Diseases for Treatment or Prevention The present invention provides methods for the treatment or prevention of a renal disease, comprising administering to a patient a therapeutically effective amount of a compound or a composition comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent. Renal diseases that can be treated by the compounds of the present invention include glomerular diseases (including but not limited to acute and chronic glomerulonephritis, rapidly progressive glomerulonepliritis, nephrotic syndrome, focal proliferative glomerulonephritis, glomerular lesions associated with systemic disease, such as systemic lupus erythematosus, Goodpasture's syndrome, multiple myeloma, diabetes, neoplasia, sickle cell disease, and chronic inflammatory diseases), tubular diseases (including but not limited to acute tubular necrosis and acute renal failure, polycystic renal diseasemeduUary sponge kidney, medullary 0 cystic disease, neplirogenic diabetes, and renal tubular acidosis), tubulointerstitial diseases (including but not limited to pyelonephritis, drug and toxin induced tubulointerstitial nephritis, hypercalcemic nephropathy, and hypokalemic nephropathy) acute and rapidly progressive renal failure, chronic renal failure, nephrolithiasis, or tumors (including but not limited to renal cell carcinoma and nephroblastoma). In a most preferred embodiment, renal diseases that are treated by the compounds of the present invention are vascular diseases, including but not limited to hypertension, nephrosclerosis, microangiopathic hemolytic anemia, atheroembolic renal disease, diffuse cortical necrosis, and renal infarcts. 4.3.7. Cancers for Treatment or Prevention Q The present invention provides methods for the treatment or prevention of cancer, comprising administering to a patient a therapeutically effective amount of a compound or a composition comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent. Cancers that can be treated or prevented by administering the compounds or the compositions of the invention include, but are not limited to, human 5 sarcomas and carcinomas, e.g., fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, meningioma, melanoma, neuroblastoma, Q retinoblastoma; leukemias, e.g., acute lymphocytic leukemia and acute myelocytic leukemia (myeloblastic, promyelocytic, niyelomonocytic, monocytic and erythroleukemia); chronic leukemia (chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia); and polycythemia vera, lymphoma (Hodgkin's disease and non-Hodgkin's disease), multiple myeloma, Waldenstrδm's macroglobulinemia, and heavy chain disease, hi a most preferred 5 embodiment, cancers that are treated or prevented by administering the compounds of the present invention are insulin resistance or Syndrome X related cancers, including but not limited to breast, prostate and colon cancer. 4.3.8. Other Diseases for Treatment or Prevention 0 The present invention provides methods for the treatment or prevention of Alzheimer's Disease, Syndrome X, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, inflammation, and impotence, comprising administering to a patient a therapeutically effective amount of a compound or a composition comprising a compound of the invention and a pharmaceutically acceptable vehicle, excipient, or diluent. 5 As used herein, "treatment or prevention of Alzheimer's Disease" encompasses treatment or prevention of lipoprotein abnormalities associated with Alzheimer's Disease. As used herein, "treatment or prevention of Syndrome X or Metabolic Syndrome" encompasses treatment or prevention of a symptom thereof, including but not limited to impaired glucose tolerance, hypertension and dyslipidemia/dyslipoproteinemia. Q As used herein, "treatment or prevention of septicemia" encompasses treatment or prevention of septic shock. As used herein, "treatment or prevention of thrombotic disorders" encompasses treatment or prevention of high blood levels of fibrinogen and promotion of fibrinolysis. In addition to treating or preventing obesity, the compounds and compositions of the 5 invention can be administered to an individual to promote weight reduction of the individual. 4.4. Surgical Uses Cardiovascular diseases such as atherosclerosis often require surgical procedures such as angioplasty. Angioplasty is often accompanied by the placement of a reinforcing a metallic tube-shaped structure known as a "stent" into a damaged coronary artery. For more serious conditions, open heart surgery such as coronary bypass surgery may be required. These surgical procedures entail using invasive surgical devices and/or implants, and are associated with a high risk of restenosis and thrombosis. Accordingly, the compounds and compositions of the invention may be used as coatings on surgical devices (e.g., catheters) Q and implants (e.g., stents) to reduce the risk of restenosis and thrombosis associated with invasive procedures used in the treatment of cardiovascular diseases. 4.5. Veterinary and Livestock Uses A composition of the invention can be administered to a non-human animal for a 5 veterinary use for treating or preventing a disease or disorder disclosed herein. In a specific embodiment, the non-human animal is a household pet. In another specific embodiment, the non-human animal is a livestock animal. In a preferred embodiment, the non-human animal is a mammal, most preferably a cow, horse, sheep, pig, cat, dog, mouse, rat, rabbit, or guinea pig. In another preferred embodiment, the non-human 0 animal is a fowl species, most preferably a chicken, turkey, duck, goose, or quail. In addition to veterinary uses, the compounds and compositions of the invention can be used to reduce the fat content of livestock to produce leaner meats. Alternatively, the compounds and compositions of the invention can be used to reduce the cholesterol content of eggs by administering the compounds to a chicken, quail, or duck hen. For non-human 5 animal uses, the compounds and compositions of the invention can be administered via the animals' feed or orally as a drench composition. 4.6. Therapeutic/Prophylactic Administration and Compositions Due to the activity of the compounds and compositions of the invention, they are 0 useful in veterinary and human medicine. As described in Section 4.3 above, the compounds and compositions of the invention are useful for the treatment or prevention of cardiovascular diseases, dyslipidemias, dyslipoproteinemias, glucose metabolism disorders, Alzheimer's Disease, Syndrome X, PPAR-associated disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and 5 impotence. The invention provides methods of treatment and prophylaxis by administration to a patient of a therapeutically effective amount of a compound or a composition comprising a compound of the invention. The patient is an animal, including, but not limited, to an animal such a cow, horse, sheep, pig, chicken, turkey, quail, cat, dog, mouse, rat, rabbit, guinea pig, etc., and is more preferably a mammal, and most preferably a human. The compounds and compositions of the invention, are preferably administered orally. The compounds and compositions of the invention may also be administered by any other convenient route, for example, by intravenous infusion or bolus injection, by absorption through epithelial or mucocutaneous linings (e.g., oral mucosa, rectal and intestinal mucosa, etc.) and may be administered together with another biologically active agent. Administration can be systemic or local. Various delivery systems are known, e.g., encapsulation in liposomes, microparticles, microcapsules, capsules, etc., and can be used to administer a compound of the invention. In certain embodiments, more than one compound of the invention is administered to a patient. Methods of administration include but are not limited to intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, intranasal, 5 epidural, oral, sublingual, intranasal, intracerebral, intravaginal, fransdermal, rectally, by inhalation, or topically, particularly to the ears, nose, eyes, or skin. The preferred mode of administration is left to the discretion of the practitioner, and will depend in-part upon the site of the medical condition. In most instances, administration will result in the release of the compounds of the invention into the bloodstream. hi specific embodiments, it may be desirable to administer one or more compounds of the invention locally to the area in need of treatment. This may be achieved, for example, and not by way of limitation, by local infusion during surgery, topical application, e.g., in conjunction with a wound dressing after surgery, by injection, by means of a catheter, by means of a suppository, or by means of an implant, said implant being of a 5 porous, non-porous, or gelatinous material, including membranes, such as sialastic membranes, or fibers. In one embodiment, administration can be by direct injection at the site (or former site) of an atherosclerotic plaque tissue. hi certain embodiments, for example, for the treatment of Alzheimer's Disease, it may be desirable to introduce one or more compounds of the invention into the central Q nervous system by any suitable route, including intraventricular, intrathecal and epidural injection. Intraventricular injection may be facilitated by an intraventricular catheter, for example, attached to a reservoir, such as an Ommaya reservoir. Pulmonary administration can also be employed, e.g., by use of an inhaler or nebulizer, and formulation with an aerosolizing agent, or via perfusion in a fluorocarbon or 5 synthetic pulmonary surfactant. In certain embodiments, the compounds of the invention can be formulated as a suppository, with traditional binders and vehicles such as triglycerides. In another embodiment, the compounds and compositions of the invention can be delivered in a vesicle, in particular a liposome (see Langer, 1990, Science 249:1527-1533; Treat et ah, in Liposomes in the Therapy of Infectious Disease and Cancer, Lopez-Berestein and Fidler (eds.), Liss, New York, pp. 353-365 (1989); Lopez-Berestein, ibid., pp. 317-327; see generally ibid.). In yet another embodiment, the compounds and compositions of the invention can be delivered in a controlled release system. In one embodiment, a pump may be used (see Langer, supra; Sefton, 1987, CRC Crit. Ref Biomed. Eng. 14:201; Buchwald et ah, 1980, Surgery 88:507 Saudek et ah, 1989, N. Engh J. Med. 321:574). hi another embodiment, polymeric materials can be used (see Medical Applications of Controlled Release, Langer and Wise (eds.), CRC Pres., Boca Raton, Florida (1974); Controlled Drug Bioavailability, Drug Product Design and Performance, Smolen and Ball (eds.), Wiley, New York (1984); Ranger and Peppas, 1983, J Macromoh Sci. Rev. Macromoh Chem. 23:61; see also Levy et ah, 1985, Science 228:190; During et ah, 1989, Ann. Neurol. 25:351; Howard et ah, 1989, J. Neurosurg. 71:105). hi yet another embodiment, a controlled-release system can be placed in proximity of the target area to be treated, e.g., the liver, thus requiring only a fraction of the systemic dose (see, e.g., Goodson, in Medical Applications of Controlled Release, supra, vol. 2, pp. 115-138 (1984)). Other controlled-release systems discussed in the review by Langer, 1990, Science 249: 1527- 1533) may be used. The present compounds and compositions will contain a therapeutically effective amount of a compound of the invention, optionally more than one compound of the invention, preferably in purified form, together with a suitable amount of a pharmaceutically acceptable vehicle, excipient, or diluent so as to provide the form for proper administration to the patient. In a specific embodiment, the term "pharmaceutically acceptable" means approved by a regulatory agency of the Federal or a state government or listed in the U.S. Pharmacopeia or other generally recognized pharmacopeia for use in animals, and more particularly in humans. The term "vehicle" refers to a diluent, adjuvant, excipient, or carrier with which a compound of the invention is administered. Such pharmaceutical vehicles can be liquids, such as water and oils, including those of petroleum, animal, vegetable or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil and the like. The pharmaceutical vehicles can be saline, gum acacia, gelatin, starch paste, talc, keratin, colloidal silica, urea, and the like, hi addition, auxiliary, stabilizing, thickening, lubricating and coloring agents may be used. When administered to a patient, the compounds and compositions of the invention and pharmaceutically acceptable vehicle, excipient, or diluents are preferably sterile. Water is a preferred vehicle when the compound of the invention is administered intravenously. Saline solutions and aqueous dextrose and glycerol solutions can also be employed as liquid vehicles, particularly for injectable solutions. Suitable pharmaceutical vehicles also include excipients such as starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, 5 talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol and the like. The present compounds and compositions, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. The present compounds and compositions can take the foπn of solutions, suspensions, emulsion, tablets, pills, pellets, capsules, capsules containing liquids, powders, i sustained-release formulations, suppositories, emulsions, aerosols, sprays, suspensions, or any other form suitable for use. In one embodiment, the pharmaceutically acceptable vehicle is a capsule (see e.g., U.S. Patent No. 5,698,155). Other examples of suitable pharmaceutical vehicles are described in "Remington's Pharmaceutical Sciences" by E.W. Martin. 15 In a preferred embodiment, the compounds and compositions of the invention are formulated in accordance with routine procedures as a pharmaceutical composition adapted for intravenous administration to human beings. Typically, compounds and compositions of the invention for intravenous administration are solutions in sterile isotonic aqueous buffer. Where necessary, the compositions may also include a solubilizing agent. Compositions for 0 intravenous administration may optionally include a local anesthetic such as lignocaine to ease pain at the site of the injection. Generally, the ingredients are supplied either separately or mixed together in unit dosage form, for example, as a dry lyophilized powder or water free concentrate in a hermetically sealed container such as an ampoule or sachette indicating the quantity of active agent. Where the compound of the invention is to be 5 administered by intravenous infusion, it can be dispensed, for example, with an infusion bottle containing sterile pharmaceutical grade water or saline. Where the compound of the invention is administered by injection, an ampoule of sterile water for injection or saline can be provided so that the ingredients may be mixed prior to administration. Compounds and compositions of the invention for oral delivery may be in the form 3 Q of tablets, lozenges, aqueous or oily suspensions, granules, powders, emulsions, capsules, syrups, or elixirs. Compounds and compositions of the invention for oral delivery can also be formulated in foods and food mixes. Orally administered compounds and compositions may contain one or more optional agents, for example, sweetening agents such as fructose, aspartame or saccharin; flavoring agents such as peppermint, oil of wintergreen, or cherry; 5 coloring agents; and preserving agents, to provide a pharmaceutically palatable preparation. Moreover, where in tablet or pill form, the compounds and compositions may be coated to delay disintegration and absorption in the gastrointestinal tract thereby providing a sustained action over an extended period of time. Selectively permeable membranes surrounding an osmotically active driving compound are also suitable for orally administered compounds and compositions of the invention. In these later platforms, fluid from the environment surrounding the capsule is imbibed by the driving compound, which swells to displace the agent or agent composition through an aperture. These delivery platforms can provide an essentially zero order delivery profile as opposed to the spiked profiles of immediate release formulations. A time delay material such as glycerol monostearate or glycerol stearate may also be used. Oral compositions can include standard vehicles such as mannitol, lactose, starch, magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, etc. Such , Q vehicles are preferably of pharmaceutical grade. The amount of a compound of the invention that will be effective in the treatment of a particular disorder or condition disclosed herein will depend on the nature of the disorder or condition, and can be determined by standard clinical techniques. In addition, in vitro or in vivo assays may optionally be employed to help identify optimal dosage ranges. The 15 precise dose to be employed in the compounds and compositions will also depend on the route of administration, and the seriousness of the disease or disorder, and should be decided according to the judgment of the practitioner and each patient's circumstances. However, suitable dosage ranges for oral administration are generally about 0.001 milligram to 200 milligrams of a compound of the invention per kilogram body weight. In specific 0 preferred embodiments of the invention, the oral dose is 0.01 milligram to 70 milligrams per kilogram body weight, more preferably 0.1 milligram to 50 milligrams per kilogram body weight, more preferably 0.5 milligram to 20 milligrams per kilogram body weight, and yet more preferably 1 milligram to 10 milligrams per kilogram body weight. In a most preferred embodiment, the oral dose is 5 milligrams of a compound of the invention per 5 kilogram body weight. The dosage amounts described herein refer to total amounts administered; that is, if more than one compound of the invention is administered, the preferred dosages correspond to the total amount of the compounds of the invention administered. Oral compositions preferably contain 10% to 95% active ingredient by weight. Q Suitable dosage ranges for intravenous (i.v.) administration are 0.01 milligram to 100 milligrams per kilogram body weight, 0.1 milligram to 35 milligrams per kilogram body weight, and 1 milligram to 10 milligrams per kilogram body weight. Suitable dosage ranges for intranasal administration are generally about 0.01 pg/kg body weight to 1 mg/kg body weight. Suppositories generally contain 0.01 milligram to 50 milligrams of a 5 compound of the invention per kilogram body weight and comprise active ingredient in the range of 0.5% to 10% by weight. Recommended dosages for intradermal, intramuscular, intraperitoneal, subcutaneous, epidural, sublingual, intracerebral, intravaginal, fransdermal admimstration or administration by inhalation are in the range of 0.001 milligram to 200 milligrams per kilogram of body weight. Suitable doses of the compounds of the invention for topical administration are in the range of 0.001 milligram to 1 milligram, depending on the area to which the compound is administered. Effective doses may be extrapolated from 5 dose-response curves derived from in vitro or animal model test systems. Such animal models and systems are well known in the art. The invention also provides pharmaceutical packs or kits comprising one or more containers filled with one or more compounds of the invention. Optionally associated with such container(s) can be a notice in the form prescribed by a governmental agency ι regulating the manufacture, use or sale of pharmaceuticals or biological products, which notice reflects approval by the agency of manufacture, use or sale for human administration, hi a certain embodiment, the kit contains more than one compound of the invention. In another embodiment, the kit comprises a compound of the invention and another lipid- mediating compound, including but not limited to a statin, a thiazolidmedione, or a fibrate. 15 The compounds of the invention are preferably assayed in vitro and in vivo, for the desired therapeutic or prophylactic activity, prior to use in humans. For example, in vitro assays can be used to determine whether administration of a specific compound of the invention or a combination of compounds of the invention is preferred for lowering fatty acid synthesis. The compounds and compositions of the invention may also be 20 demonstrated to be effective and safe using animal model systems. Other methods will be known to the skilled artisan and are within the scope of the invention. 4.7. Combination Therapy 2 In certain embodiments of the present invention, the compounds and compositions of the invention can be used in combination therapy with at least one other therapeutic agent. The compound of the invention and the therapeutic agent can act additively or, more preferably, synergistically. In a preferred embodiment, a compound or a composition comprising a compound of the invention is administered concurrently with the 3 Q administration of another therapeutic agent, which can be part of the same composition as the compound of the invention or a different composition, hi another embodiment, a compound or a composition comprising a compound of the invention is administered prior or subsequent to administration of another therapeutic agent. As many of the disorders for which the compounds and compositions of the invention are useful in treating are chronic 35 disorders, in one embodiment combination therapy involves alternating between administering a compound or a composition comprising a compound of the invention and a composition comprising another therapeutic agent, e.g., to minimize the toxicity associated with a particular drug. The duration of administration of each drug or therapeutic agent can be, e.g., one month, three months, six months, or a year, hi certain embodiments, when a composition of the invention is administered concurrently with another therapeutic agent that potentially produces adverse side effects including but not limited to toxicity, the 5 therapeutic agent can advantageously be administered at a dose that falls below the threshold at which the adverse side is elicited. The present compounds and compositions can be administered together with a statin. Statins for use in combination with the compounds and compositions of the invention include but are not limited to atorvastatin, pravastatin, fluvastatin, lovastatin, 1 simvastatin, and cerivastatin. The present compounds and compositions can also be administered together with a PPAR agonist, for example a thiazolidmedione or a fibrate. Thiazolidinediones for use in combination with the compounds and compositions of the invention include but are not limited to 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione, troglitazone, pioglitazone, ciglitazone, WAY-120,744, englitazone, AD 5075, darglitazone, and rosiglitazone. Fibrates for use in combination with the compounds and compositions of the invention include but are not limited to gemfibrozil, fenofibrate, clofibrate, or ciprofibrate. As mentioned previously, a therapeutically effective amount of a fibrate or thiazolidmedione often has toxic side effects. Accordingly, in a preferred embodiment of 2o the present invention, when a composition of the invention is administered in combination with a PPAR agonist, the dosage of the PPAR agonist is below that which is accompanied by toxic side effects. The present compounds and compositions can also be administered together with a bile-acid-binding resin. Bile-acid-binding resins for use in combination with the 25 compounds and compositions of the invention include but are not limited to cholestyramme and colestipol hydrochloride. The present compounds and compositions can also be administered together with niacin or nicotinic acid. The present compounds and compositions can also be administered together with a RXR agonist. RXR agonists for use in combination with the compounds of the invention include but are not limited to LG 30 100268, LGD 1069, 9-cis retinoic acid, 2-(l-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-cyclopropyl)-pyridine-5- carboxylic acid, or 4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)2-carbonyl)- benzoic acid. The present compounds and compositions can also be administered together with an anti-obesity drug. Anti-obesity drugs for use in combination with the compounds of 35 the invention include but are not limited to β-adrenergic receptor agonists, preferably β-3 receptor agonists, fenfluramine, dexfenfluramine, sibutramine, bupropion, fluoxetine, and phentermine. The present compounds and compositions can also be administered together with a hormone. Hormones for use in combination with the compounds of the invention include but are not limited to thyroid hormone, estrogen and insulin. Preferred insulins include but are not limited to injectable insulin, fransdermal insulin, inhaled insulin, or any combination thereof. As an alternative to insulin, an insulin derivative, secretagogue, sensitizer or mimetic may be used. Insulin secretagogues for use in combination with the compounds of the invention include but are not limited to forskolin, dibutryl cAMP or isobutylmethylxanthine (IBMX). The present compounds and compositions can also be administered together with a tyrophostine or an analog thereof. Tyrophostines for use in combination with the Q compounds of the invention include but are not limited to tryophostine 51. The present compounds and compositions can also be administered together with sulfonylurea-based drugs. Sulfonylurea-based drugs for use in combination with the compounds of the invention include, but are not limited to, glisoxepid, glyburide, acetohexamide, chlorpropamide, glibornuride, tolbutamide, tolazamide, glipizide, 5 gliclazide, gliquidone, glyhexamide, phenbutamide, and tolcyclamide. The present compounds and compositions can also be administered together with a biguanide. Biguanides for use in combination with the compounds of the invention include but are not limited to metformin, phenformin and buformin. The present compounds and compositions can also be administered together with an α-glucosidase inhibitor, α-glucosidase inhibitors 0 for use in combination with the compounds of the invention include but are not limited to acarbose and miglitol. The present compounds and compositions can also be administered together with an apo A-I agonist. In one embodiment, the apo A-I agonist is the Milano form of apo A-I (apo A-EVI). In a preferred mode of the embodiment, the apo A-EVI for administration in 5 conjunction with the compounds of the invention is produced by the method of U.S. Patent No. 5,721,114 to Abrahamsen. hi a more preferred embodiment, the apo A-I agonist is a peptide agonist. In a preferred mode of the embodiment, the apo A-I peptide agonist for administration in conjunction with the compounds of the invention is a peptide of U.S. Patent No. 6,004,925 or 6,037,323 to Dasseux. Q The present compounds and compositions can also be administered together with apolipoprotein E (apo E). In a preferred mode of the embodiment, the apoE for administration in conjunction with the compounds of the invention is produced by the method of U.S. Patent No. 5,834,596 to Ageland. In yet other embodiments, the present compounds and compositions can be 5 administered together with an HDL-raising drug; an HDL enhancer; or a regulator of the apolipoprotein A-I, apolipoprotein A-IN and/or apolipoprotein genes. 4.8. Combination Therapy with Cardiovascular Drugs The present compounds and compositions can be administered together with a known cardiovascular drug. Cardiovascular drugs for use in combination with the compounds of the invention to prevent or treat cardiovascular diseases include but are not limited to peripheral antiadrenergic drugs, centrally acting antihypertensive drugs (e.g., methyldopa, methyldopa HCl), antihypertensive direct vasodilators (e.g., diazoxide, hydralazine HCl), drugs affecting renin-angiotensin system, peripheral vasodilators, phentolamine, antianginal drugs, cardiac glycosides, inodilators (e.g., amrinone, milrinone, enoximone, fenoximone, imazodan, sulmazole), antidysrhythmic drugs, calcium entry blockers, ranitine, bosentan, and rezulin. 4.9. Combination Therapy for Cancer Treatment The present compounds and compositions can be administered together with treatment with irradiation or one or more chemotherapeutic agents. For irridiation treatment, the irradiation can be gamma rays or X-rays. For a general overview of radiation therapy, see Hellman, Chapter 12: Principles of Radiation Therapy Cancer, in: Principles and Practice of Oncology, DeNita et ah, eds., 2 nd . Ed., J.B. Lippencott Company, Philadelphia. Useful chemotherapeutic agents include methotrexate, taxol, mercaptopurine, thioguanine, hydroxyurea, cytarabine, cyclophosphamide, ifosfamide, nitrosoureas, cisplatin, carboplatin, mitomycin, dacarbazine, procarbizine, etoposides, campathecins, bleomycin, doxorubicin, idarubicin, daunorubicin, dactinomycin, plicamycin, mitoxantrone, asparaginase, vinblastine, vincristine, vinorelbine, paclitaxel, and docetaxel. In a specific embodiment, a composition of the invention further comprises one or more chemotherapeutic agents and/or is administered concurrently with radiation therapy, hi another specific embodiment, chemotherapy or radiation therapy is administered prior or subsequent to administration of a present composition, preferably at least an hour, five hours, 12 hours, a day, a week, a month, more preferably several months (e.g., up to tliree months), subsequent to administration of a composition of the invention. 5. EXAMPLES 5.1.a. Synthesis of 6-(5,5-DimethyI-6-hydroxy-hexane- l-sulfinyl)-2,2-dimethyl-hexan-l-ol referred to herein as Compound A 6-(6-Hydroxy-5,5-dimethyl-hexane- 1 -sulfϊnyl)- 2,2-dimethyl-hexan- 1 -ol 6-(5,5-Dimethyl-6-hvdroxy-hexane-l-sulfinyl)-2,2-dimethyl-hexan-l-ol To a solution of 6-(5,5-dimethyl-6-hydroxy-hexyl-sulfanyl)-2,2-dimethyl-hexan-l-ol (5.1 g, 17.5 mmol) in glacial acetic acid (25 ml) was added hydrogen peroxide (50 wt.% in water; 1.20 g; 17.5 mmol). The reaction mixture was stirred at rt for 22 h, then diluted with water (200 ml), and extracted with chloroform (2 x 150 ml). The combined organic phases were subsequently washed with saturated NaHCO 3 solution (3 x 100 ml) and saturated NaCl solution (100 ml), dried over MgSO 4 , concentrated in vacuo, and dried in high vacuo to give crude product (5.60 g; 105%) as a clear oil. Η NMR (300 MHz, CDC1 3 ) δ ppp = 3.29 (AB, 2 H, J = 12.2); 3.27 (AB, 2 H, J = 12.2); 2.70 (m, 4 H); 2.48 (s br, 2 H); 1.76 (m, 4 H); 1.44 (m, 4 H); 1.30 (4 H); 0.87 (s, 6 H); 0.86 (s, 6H). 13 C NMR (75 MHz, CDC1 3 ) δ ppp = 76.80; 71.39; 52.20; 38.08; 35.15; 24.21; 24.03; 23.66; 23.26. Calcd. for C 16 H 35 SO 3 (MH+): 307.2307, found 307.2309. 5.1.b. Synthesis of 6-(6-Hydroxy-5-methyl-5- phenylhexylsulfinyl)-2-methyl-2-phenylhexan-l-ol 6-(6-Hydroxy-5-methyl-5-phenylhexyIsulfinyl)-2-methyI-2-phenylhexan-l-ol To a solution of 6-(6-hydroxy-5-methyl-5-phenylhexylsulfanyl)-2-methyl-2- phenylhexan-1-ol (3.0 g, 7.0 mmol) in glacial acetic acid (20 mL) was added hydrogen peroxide (50 wt. % in water; 0.5 mL, 7.0 mmol). The reaction mixture was stirred at rt for 22 h, then diluted with water (100 mL), and extracted with chloroform (3 x 80 mL). The combined organic phases were subsequently washed with saturated NaHCO 3 solution (3 x 80 mL) and saturated NaCl solution (80 mL), dried over MgSO 4 , concentrated in vacuo, and dried in high vacuo to give crude 6-(6-hydroxy-5-methyl-5-phenylhexylsulfinyl)-2-methyl- 2-phenylhexan-l-ol (2.63 g 88 %) as an oil. Η NMR (300 MHz, CDC1 3 /TMS): δ (ppm): 7.42 - 7.12 (m, 10 H), 3.78 - 3.58 (m, 2 H), 3.58 - 3.45 (m, 2 H), 2.90 - 2.70 (m, 2 H), 2.68 - 2.39 (m, 2 H), 1.95 - 1.50 (m, 8 H), 1.50 - 1.00 (m, 10 H). 13 C NMR (75 MHz, CDCL/TMS): δ (ppm): 144.5, 144.4, 128.4, 128.3, 126.5, 126.2, 126.1, 72.2, 72.1, 71.9, 52.4, 52.0, 43.2, 37.8, 37.7, 23.2, 22.9, 22.4, 21.7, 21.5. HRMS (LSIMS, nba): Calcd. for C 26 H 39 O 3 S ! (MH + ): 431.2620, found: 431.2611. 5. I.e. Synthesis of 5-(5-Hydroxy-4,4-dimethyl- pentyl-l-sulfinylV2,2-dimethyl-pentan-l-ol acet c aci 5-(5-Hydroxy-4,4-dimethyl-pentyl-l-sulfinyl -2,2-dimethyl-pentan-l-ol To a solution of 5-(5-hydroxy-4,4-dimethyl-ρentyl-l-sulfanyl)-2,2-dimethyl-pentan- l-ol (10.0 g, 38.0 mmol) in glacial acetic acid (50 mL) was added hydrogen peroxide (50 wt. % in water, 2.64 g, 38.0 mmol) while cooling in an ice-water bath. The reaction mixture was stirred at below 5 ° C for 4 h and stored in a refrigerator overnight. The reaction mixture was diluted with water (500 mL) and extracted with chloroform (2 x 250 mL). The combined organic phases were subsequently washed with saturated NaHCO 3 solution (2 x 300 mL) and saturated NaCl solution (200 mL), dried over MgSO 4 , concentrated in vacuo, and dried in high vacuo to give the crude product (12.8 g) as a clear oil. The crude product was dissolved in hot ethyl acetate (ca. 20 mL) and filtered. Hexanes were slowly added to this solution until a slight turbidity was produced, which was cleared by addition of a small portion of ethyl acetate. The solution was allowed to cool to rt and stored at -5 ° C overnight to give 5-(5-hydroxy-4,4-dimethyl-pentyl-l-sulfmyl)-2,2-dimethyl-pentan-l-ol (7.10 g, 67.2 %) as a white, crystalline solid. Mp.: 53 -54 °C. Η NMR (300 MHz, CDC1/TMS): δ (ppm): 3.31 (m, 4 H), 2.78 - 2.50 (m, 4 H), 2.45 (br., 2 H), 1.67 - 1.80 (m, 4 H), 1.50 - 1.25 (m, 4 H), 0.87 (s, 6 H), 0.86 (s, 6 H). 13 C NMR (75 MHz, CDC1 TMS): δ (ppm): 70.82, 52.82, 37.35, 35.16, 24.16, 23.86, 17.43. HRMS (LSIMS, gly): Calcd. for C 14 H 3I O 3 Sι (MET): 279.1994, found: 279.2015. 5.1. d. Synthesis of 5-(5-Hydroxy-4-methyI- 4-phenylpentylsulfinylV2-methyl-2-phenylpentan-l-ol 5 5-(5-Hydroxy-4-methyl-4-phenyIpentylsuIfinyl)-2-methyl-2-phenylpentan-l-ol To a solution of 5-(5-hydroxy-4-methyl-4-ρhenylpentylsulfanyl)-2-methyl-2- phenylpentan-1-ol (3.37 g, 8.14 mmol) in glacial acetic acid (100 mL) was added 50 % aqueous hydrogen peroxide solution (0.55 g, 8.14 mmol) drop-wise at rt over 5 min. The 10 reaction mixture was stirred at rt for 3 h, while the reaction progress was monitored by TLC (dichloromethane /ethyl acetate = 2 / 1). The reaction mixture was concentrated to yield a crude product (3.5 g) that was purified by column chromatography on silica gel (dichloromethane, then dichloromethane / ethyl acetate =1 / 1, followed by dichloromethane / ethanol = 1 / 1). The product-containing fractions were concentrated and dried at 120 °C 15 under high vacuo for 2.5 h to give 5-(5-hydroxy-4-methyl-4-phenylpentylsulfinyl)-2-methyl- 2-phenylpentan-l-ol (2.55 g, 71 %) as colorless, viscous oil. 'H NMR (300 MHz, CDC1 TMS): δ (ppm): 7.30 (m, 8 H), 7.20 (m, 2 H), 3.66 - 3.56 (m, 4 H), 2.54 - 2.38 (m, 4 H), 2.13 (br., 2 H), 1.90 - 1.43 (m, 8 H), 1.33 (s, 6 H). 13 C NMR (75 MHz, CDC1 3 /TMS): δ (ppm): 144.56, 128.68, 126.66, 126.62, 126.62, 71.82, 71.57, 52.92, 43.38, 43.35, 37.56, 20 37.43, 22.14, 21.77, 17.87, 17.71. HRMS (LSIMS, gly): Calcd. for C^H^S j (MH + ): 403.2307, found: 403.2295. 5.2. LDL-CholesteroI, HDL-Cholesterol and Triglyceride Levels in Male Sprague-Dawley Rats 25 illustrative compounds of the invention are administered daily at a dose of 100 mg/kg to chow fed male Sprague-Dawley rats for seven days in the morning by oral gavage in 1.5% carboxymethylcellulose/0.2% Tween-20 (dosing vehicle). Animals are weighed daily. Animals are allowed free access to rodent chow and water throughout the study. After the seventh dose, animals are sacrificed in the evening and blood serum is assayed for 30 lipoprotein cholesterol profiles, serum triglycerides, total cholesterol VLDL, LDL, and HDL cholesterol, and the ratio of HDL cholesterol to that of VLDL plus LDL cholesterol, apolipoproteins A-I, C-JJ, C-1JJ, and E by immunoelectrophoresis, and percent weight gain. 35 5.3. LDL-CholesteroI, HDL- Cholesterol and Triglyceride Levels in Obese Female Zucker Rats 5.3.1. Experiment A Dosing vehicle, Compound A (86 mg/kg of body weight) or troglitazone (120 mg/kg of body weight) is administered to eight week old female obese Zucker rats daily for seven days in the morning by oral gavage in 1.5% carboxymethylcellulose/0.2% Tween-20. Troglitazone is obtained commercially. Finely crushed tablets are suspended in vehicle for dosing. Orbital blood samples are obtained following a six-hour fast prior to the initial dose and also following the seventh dose. Blood serum is assayed for total cholesterol and triglycerides, lipoprotein cholesterol profiles, VLDL plus LDL cholesterol combined (also referred to as apo B containing lipoprotein cholesterol or non-HDL cholesterol), HDL cholesterol, and the ratio of HDL cholesterol to that of VLDL plus LDL cholesterol, serum glucose, and non-esterified fatty acids, and percent weight gain. 5.3.2. Experiments B. C, D. & E In a number of different experiments, illustrative compounds of the invention and troglitazone are administered daily at various doses to 10- week old chow fed obese female Zucker rats for 14 days in the morning by oral gavage in 1.5% carboxymethylcellulose/0.2% Tween-20 (dosing vehicle). Animals are weighed daily. Animals are allowed free access to rodent chow and water throughout the study. Blood glucose is determined after a 6-hour fast in the afternoon without anesthesia from a tail vein. Serum is also prepared from a blood sample subsequently obtained from the orbital venous plexus (with O 2 /CO 2 anesthesia) prior to and after one week treatment and used lipid and insulin determinations. At two weeks, blood glucose is again determined after a 6-hour fast without anesthesia from a tail vein. Soon thereafter, animals are sacrificed by CO 2 inhalation in the evening and cardiac blood serum is collected and assessed for various lipids and insulin. Body weight is determined daily prior to dosing and at the time of euthanasia. Blood glucose and serum insulin levels are determined from fasted rats just prior to and following one and two weeks of treatment. Percent liver to body weight is determined after two weeks of treatment at the time of sacrifice. 5.4. Lipoprotein Cholesterol Profile in LDL Receptor-Deficient Mice Homozygous familial hypercholesterolemia is a rare human disease (~1/1, 000,000) characterized by absent or defective LDL receptors, markedly elevated serum LDL cholesterol levels and very early and severe onset of atherosclerosis. The more common form of this disease in humans, heterozygous familial hypercholesterolemia , occurs in about one in every 500 humans. Patients with the heterozygous form of this disease also present with elevated LDL levels and early onset of atherosclerosis. The effect of Compound A on LDL levels in a murine model of homozygous familial hypercholesterolemia can be studied according to the methods described in Ishibasbi et ah, 1993, J. Clin. Invest. 92:883-893; Ishibashi et ah, 1994, J. Clin. Invest. 93:1885-1893, incorporated by reference herein. LDL receptor-deficient mice have elevated LDL cholesterol relative to wild type mice when fed a chow diet. When fed cholesterol- enriched diets, these mice develop atherosclerosis. 0 5.5. Synthesis of Non-Saponified and Saponified Lipids in Hepatocytes Isolated from a Male Sprague-Dawley Rat Washout buffer containing; 149 mM sodium chloride, 9.2 mM sodium N-2- hyroxyethylpiperazine-N'-2-ethanesulfonic acid, 1.7 mM fructose, 0.5 mM EGTA, 10 U/mL heparin at pH 7.5 and digestion buffer containing; 6.7 mM potassium chloride, 143 mM 5 sodium chloride, 9.2 mM sodium N-2-hyroxyethylpiperazine-N'-2-ethanesulfonic acid, 5 mM calcium chloride-dihydrate, 1.7 mM fructose, 0.2% bovine serum albumin, 100 U/mL collagenase Type I, 93 U/mL Hyaluronidase, 160 BAEE/ mL trypsin inhibitor at pH 7.5 were prepared. Solutions were oxygenate prior to perfusion. Wash buffer containing Dulbecco's Modified Eagle Medium (DMEM) containing 4.5 gm/L D-glucose, 2 mM o GlutMax-1, 0.2% BSA, 5% fetal bovine serum (FBS), 12 nM insulin, 1.2 μM hydrocortisone and DMEM+HS solution containing DMEM, 2 mM GlutMax-1, 20 nM delta-antinolevulinic acid, 17.4mM MEM non-essential amino acids, 20%o FBS, 12 nM insulin and 1.2 μM hydrocortisone was prepared. DMEM solution containing DMEM, 2 mM GlutMax-1, 20 nM delta-aminolevulinic acid and 17.4 mM MEM non-essential amino 5 acids were prepared. Male Sprague-Dawley rats weighing 125-250gms were maintained on a standard rodent chow diet and freely given water. On the evening prior to cell isolation, selected healthy animals were fed restricted. The rat was anesthetized with a 50 mg/kg intraperitoneal administration of sodium pentobarbital. Clotting was minimized with intraperitoneal administer of heparin at 1000 IU/kg body weight. The abdominal cavity was Q opened and the portal vein was surgical isolated. The angiocatheter was inserted into the portal vein at the general location of the lineal branch and connected to a perfusion pump. The in situ perfusion was performed at (-30 mL/min) with washout buffer, equilibrated with atmosphere gases at a temperature of 37°C. The internal iliac artery was cut to allow pressure equilibration. The caustal area of the diaphragm was excised to provide access to 5 the caudal vena cava and the aorta, using curved forceps both vessels were occluded. About 200 mL of buffer was needed to clear the liver. Digestion buffer was circulated at the same flow rate for about 7 minutes after the initial entry of digestion buffer into the liver. When the liver had significantly increased in size) and consistency, and started to leak perfusate the perfusion was discontinued. The liver was rinsed in situ with sterile saline and surgical removed from the animal to a sterile beaker. Additional digestion solution was dispensed into the beaker and cap with foil. The liver tissue was gently shaken using sterile forceps to flee hepatocyte cells. Cells were filtered through presterilized stainless steels mesh sieves of pore sizes 250, 106 and 75 μm. Cells were diluted in with ice-cold wash buffer, pipetted successively to assist the disassociation of the cells and transferred to a 50 mL tube. The cells are centrifuged for about 4 minutes at 50 x g to form a loosely packed pellet. The supernatant is discarded and the pelleted cells were resuspend in ice-cold wash buffer. The washing procedure was repeated twice for a total of three washes. The final pellet was suspended in 50 mL of wash buffer and held on wet-ice. The viability and cell number was checked by diluting duplicate 100 μL aliquots of cell suspension with 400 μL of wash buffer and 500 μL of 0.4% trypan blue in isotonic buffer. The cell concentration was determined in several fields on the hemocytometer. The cell viability (those that exclude die) was 85% or greater. Cells were diluted in DMEM+HS to a final concentration to ensure plating at a density of 150,000 cells/cm 2 on collagen coated 6- or 12-well plates. Four hours after plating change the media was changed with DMEM- and culture overnight. Solutions of lovastatin, and illustrative compounds were prepared at 30 mM with DMSO. To obtain a compound solution mixtures were vortexed and sonicated. o To evaluate the effect of reference and illustrative compounds on saponified and non-saponifed lipid synthesis, the monolayer cultures were exposed to compounds formulated in DMEM- containing 14 C-acetate. All cells were exposed to 1% DMSO. Metabolic labeling with 14 C-acetate continued for 4 hr at 37 °C. After labeling, cells were washed twice with 1 mL of PBS followed by lysing in 1 mL deionized water. Cells were 5 scraped from the dishes and transferred to glass tubes at which point they were sonicated, 2.5 mL of 2:1 chloroform/methanol mixture was added followed by 1.5 mL of Phosphate Buffered Saline (PBS). To correct for extraction efficiency in the upcoming extractions, 3000 dpmn of 3 H-cholesterol was added to each tube. Tubes were shaken for 30 min. to extract lipids into the organic phase followed by centrifugation for 10 minutes at 1000 x g to Q separate the organic and aqueous phases. The lower organic phase containing total lipids was removed and planed in a new tube. The organic solution was evaporated under N . Resuspend the dry lipid extract in 1 mL of 93% ethanol containing 1 M KOH and placed at 70°C for 2.5 hours. After the reaction and cooling, 2 mL of hexane and 2.5 mL of water was added to each tube followed by rigorous shaking for 10 min. Tubes were centrifuged 5 for 10 min. at 1000 x g and the organic (top) layer containing the non-saponifed lipids was transferred to a new tube followed by evaporation of the organic solvent under N 2 . The aqueous phase containing the saponfied lipids was also transferred to a new tube. The non- saponified lipid extract, after drying, was suspended in toluene and an aliquot added to scintillation cocktail followed by radioactive counting. 14 C counts representing the incorporation of 14 C acetate into non-saponified lipids was corrected by the 3 H counts, which represented the extraction efficiency of the procedure as, noted above by the addition of 3 H cholesterol. To isolate saponified lipids, 1.5 mL of aqueous phase solution was mixed with 400ul of EVI HCl and then lipids extracted by the addition of 2.5 L of 2:1 chloroform: methanol, 1.5 mL of PBS, and 1 mL of water followed by rigorous shaking and isolation of the organic phase. Resuspend the N 2 dried organic phase action in toluene, and measure radioactivity using liquid scintillant method. The rate of 1 C-acetate incorporation Q into saponified and non-saponified lipids is reported. FIG. 3 shows the rates of saponified, non-saponified lipid synthesis following treatment with lovastatin and illustrative compound of the invention. Data are represented as a percent of no compound treatment (Vehicle control). Data are represented as the mean of three measurements _+/- one standard deviation. The data indicate that the illustrative 5 compound of the invention is useful for inhibition of lipid synthesis. In particular, compound A at 30 μM reduced the rates of saponifiable and non-saponifiable lipid synthesis by 25 and 54% respectively in the rat hepatocyte cells. Compound A, or a pharmaceutically acceptable salt thereof, is useful for inhibiting the synthesis of saponified and non-saponifiable lipid. 0 5.6. Cytotoxicity To evaluate cytotoxicity, monolayer hepatocyte cultures are exposed to increasing concentrations of up to 250 μM Compound A in DMEM+ for 24 hours. Control cells are exposed to the same media lacking a test compound. All cells are exposed to 0.1% DMSO. The measure of cytotoxicity, release of lactate dehydrogenase (LDH) from the cytosolic compartment of hepatocyte monolayer cultures, reflects damage to the plasma membrane. The assay, is based on the method of Wroblewski and LaDue,1955, Proc. Soc. Exp. Biol. Med. 90:210-213; see also Ulrich et ah, 1995, Toxicoh Lett. 82/83:107-115. describing the use of hepatocytes as models for hepatic toxicity), and measures the LDH activity in tissue culture medium and a cell homogenate. Briefly, all the media are removed from plates and transferred to a separate plate. Following removal of media, attached cells are lysed with a hypotonic Tris/Glycerol/EDTA buffer (0.1 M Tris, 20% glycerol, 1 mM EDTA pH 7.3). Activity of LDH in medium and cells is measured spectrophotometrically by monitoring the rate of pyruvate reduction to lactate, coupled with oxidation of NADH; the rate of 5 absorbance change is measured at 340 nm. Cytotoxicity is expressed as a ratio using the following equation: (LDH in medium / (LDH in medium + LDH in solubilized hepatocytes)) = R. 5.7. Insulin Sensitization Effects Effects of Compound A on rate of differentiation of 3T3-L1 cells from a "committed 5 pre-adipocyte" to an "adipocyte" phenotype in the absence or presence of insulin is tested. The differentiation of 3T3-L1 cells to an adipocyte-like phenotype is highly dependent upon insulin. This insulin-dependent changes in cellular morphology and metabolism, including: expression of adipocyte-specific genes, greatly increased levels of glucose uptake and metabolism, induction of GLUT4 (and increased expression of GLUT 1) glucose ι Q transporters, greatly increased lipid synthesis and deposition of intracellular lipid droplets, in this assay the degree of differentiation is a reflection of the rate of lipid synthesis, as measured through incorporation of 14 C-acetate over 2 hours. Thus the ability of a compound to stimulate a submaximal insulin response would suggest an insulin-sensitizing activity (Kletzein et ah, 1991, Molecular Pharm.4l:393-398). 5 3T3-L1 stem cells are induced to differentiate with dexamethasone, isobutylmethylxanthine and insulin (Green and Kehinde, 1975, Cell 5:19-27). Cells are plated in Dulbecco's modified Eagle medium containing 10% calf serum and grown to confluence. Cells are then refreshed with 10% fetal calf serum, and treated with 0.5 mM isobutylmethylxanthine and 250 nM dexamethasone, but no additional insulin, for 48 hours. 2 This treatment induces the differentiation of 3T3-L1 cells into pre-adipocytes. Conversion of preadipocytes to adipocyte phenotype requires the removal of dexamethasone and the presence of insulin, which stimulates differentiation of preadipocytes into adipocytes in a concentration- and time-dependent manner. A maximal insulin effect occurs at about 100 nM insulin, and leads to nearly complete (95-100%) conversion to adipocytes within 4 days. 25 The preadipocytes are then treated for 4 days with various concentrations of Compound A in 5% fetal calf serum in Dulbecco's modified Eagles medium, with or without a submaximal concentration of insulin (30 nM). Following this four-day treatment, the predipocytes are pulsed with 0.1 mCi I4 C-acetate per well for 2 hours. Cell are then washed with phosphate buffered saline, lysed with 0.1 N NaOH, and 14 C-acetate 3 Q incorporation into 5.8. In Vivo Biological Data Dosing vehicle of Compound A (100 mg/kg) was administered to 9-10 week old 35 female obese Zucker rats (z ' .e. the fa/fa or leptin receptor deficient rat) daily for 14 days in the morning by oral gavage in 1.5 percent carboxymethylcellulose/0.2 percent between-20. Tail vein blood for glucose determinations (without anesthesia) and orbital blood samples for serum (with anestehesia for all other determinations) were obtained following a 6 hour fast prior to the initial dose and after one and two weeks of dosing. Blood serum were assayed for insulin, non-esterified fatty acids, β-hydroxy butyrate, total cholesterol, and triglycerides (Figure 2). Glucose was determined in whole 5 blood (Table 1). Blood serum was also used to produce lipoprotein cholesterol profiles (Figure 2), and used to determine VLDL plus LDL cholesterol combined (also referred to as apoB containing lipoprotein cholesterol or non-HDL cholesterol), HDL cholesterol, and the ratio of HDL cholesterol to that of VLDL plus LDL cholesterol (Figure 2). In addition, the effect of Compound A on weight gain after 14 days and the liver to body weight ratio at ι sacrifice are shown in Figure 2. In the Zucker rat. Compound A increased total serum cholesterol by 98, and 74 percent after one and two weeks of treatment, respectively. Vehicle treatment resulted in only a -10 and 10 change of total serum cholesterol after one and two weeks of treatment, respectively (Figure 2). Serum triglycerides were reduced by 48 and 42 percent with 15 ESP31015 treatment after one and two weeks of treatment (Figure 2). Lipoprotein cholesterol profiles shows treatment with Compound A resulted in a marked alteration in the distribution of cholesterol among lipoproteins (Figure 1). In particular, Compound A caused a marked elevation in HDL cholesterol after one week of treatment, which was further elevated after two weeks of treatment. Using the serum total 2 cholesterol values (Figure 2) and the lipoprotein cholesterol distribution (Figure 1), the amount of cholesterol associated with non-HDL (i.e. VLDL plus LDL cholesterol) and HDL cholesterol were determined (Figure 2). Although Compound A increased non-HDL cholesterol by 38 and 62 percent, the marked increase in HDL cholesterol of 2.2-fold and 3.1 -fold after one and two weeks of treatment, respectively, resulted in an unexpectedly 25 beneficial increased ratio of HDL/non-HDL cholesterol from 2.70 (pretreatment) to 3.84 and 4.97 after one-week and two-weeks of treatment, respectively. Impaired glucose tolerance is the metabolic symptom beginning at about 8-12 weeks of age in obese female Zucker rats and therefore the animals are able to maintain normal glucose levels at the expense of elevated insulin levels. As shown in Figure 2, 3 Q pretreatment and posttreatinent blood glucose levels were similar after one and two weeks of Compound A treatment. Thus, Compound A treatment did not induce a hypoglycemic state nor accelerate diabetes progression. An indication of an improved diabetic state is the reduction of non-esterified fatty acids from 2.28 to 0.74 mmol/L after two weeks of Compound A coupled to an elevation in β-hydroxy butyrate from 2.35 to 3.94 mg/dL. 35 These data may reflect an enhanced hepatic β-oxidation of excess fatty acids resulting from the reduction of serum non-esterified fatty acids and triglycerides (Figure 2). The present invention is not to be limited in scope by the specific embodiments disclosed in the examples which are intended as illustrations of a few aspects of the invention and any embodiments which are functionally equivalent are within the scope of this invention. Indeed, various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art and are intended to fall within the appended claims.

Claims: What is claimed is: 1. A compound of a formula I: or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) each occurrence of Z is independently CH 2 , CH=CH, or phenyl, where each occurrence of m is independently an integer ranging from 1 to 9, but when Z is phenyl then its associated m is 1; (b) G is (CH 2 ) X , where x is 2, 3, or 4 CH 2 CH=CHCH 2 , CH=CH, CH 2 -phenyl-CH 2 , or phenyl; (c) W 1 and W 2 are independently L, V, C(R 1 )(R 2 )-(CH 2 ) C -C(R 3 )(R 4 )-(CH 2 ) -Y, or C(R 1 )(R 2 )-(CH 2 ) C -V where c is 1 or 2 and n is an integer ranging from 0 to 4; (d) each occurrence of R 1 or R 2 is independently (C j -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl or when one or both of W 1 and W 2 is C(R 1 )(R 2 )-(CH 2 ) C -C(R 3 )(R )-Y, then R 1 and R 2 can both be H to form a methylene g 1"011 ?; (e) R 3 is H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C j -C^alkoxy, phenyl, benzyl, Cl, Br, CN, NO 2 , or CF 3 ; (f) R 4 is OH, ( - alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, phenyl, benzyl, Cl, Br, CN, NO 2 , or CF 3 ; (g) L is C(R 1 )(R 2 )-(CH 2 ) n -Y; (h) V is: (i) each occurrence of Y is independently OH, COOH, CHO, COOR 5 , SO 3 H, wherein: (i) R s is (C j -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, ( -C^alkoxy, or phenyl groups, (ii) each occurrence of R 6 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, Cγ-C 6 alkoxy, or phenyl groups; and (iii) each occurrence of R 7 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl. The compound of claim 1, wherein: (a) W 1 and W 2 are independently L, V, or C(R')(R 2 )-(CH 2 ) C -V where c is 1 or 2; and (b) R 1 or R 2 are independently ( -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl. 3. The compound of claim 1 , wherein W 1 is L. 4. The compound of claim 1, wherein W 1 is V. 5. The compound of claim 1, wherein W 1 is C(R 1 )(R 2 )-(CH 2 ) c -C(R 3 )(R 4 )-(CH 2 ) n -Y. 6. The compound of claim 1 , wherem W 1 is C(R I )(R 2 )-(CH 2 ) C -V. 7. The compound of claim 1 , wherein W 1 and W 2 are independent L groups. 8. The compound of claim 7, wherein each occurrence of Y is independently OH, COOR 5 , or COOH. 9. A compound of the formula la: la or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) each occurrence of Z is independently CH 2 or CH=CH, where each occurrence of m is independently an integer ranging from 1 to 9; (b) G is (CH 2 ) X , CH 2 CH=CHCH 2 , or CH=CH, where x is 2, 3, or 4; (c) W 1 and W 2 are independently L, V, or C(R')(R 2 )-(CH 2 ) C -V where c is 1 or 2; (d) each occurrence of R 1 or R 2 is independently ( -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl; (e) L is C(R 1 )(R 2 )-(CH 2 ) n -Y, where n is an integer ranging from 0 to 4; (f) V is: (g) each occurrence of Y is independently OH, COOH, CHO, COOR 3 , SO 3 H, wherein: (i) R 3 is (C j -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (Cι-C 6 )alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (C,-C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, - alkoxy, or phenyl groups; and (iii) each occurrence of R 5 is independently H, (C,-C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl. 10. The compound of claim 9, wherein W 1 is L. 11. The compound of claim 9, wherein W 1 is V. 12. The compound of claim 9, wherein W 1 is C(R 1 )(R 2 )-(CH 2 ) C -V. 13. The compoimd of claim 9, wherein W 1 and W 2 are independent L groups. 14. The compoimd of claim 13, wherein each occurrence of Y is independently OH, COOR 3 , or COOH. 15. A compound of the formula lb : lb or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein: (a) each occurrence of m is independently an integer ranging from 1 to 9; (b) x is 2, 3, or 4; (c) n is an intependent integer ranging from 0 to 4; (d) each occurrence of R 1 or R 2 is independently (C j -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl; and (e) each occurrence of Y is independently OH, COOH, CHO, COOR 3 , SO 3 H, wherein: (i) R 3 is ( -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, or phenyl groups, (ii) each occurrence of R 4 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, - alkoxy, or phenyl groups; and (iii) each occurrence of R 5 is independently H, (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl. 16. The compound of claim 15, wherein each occurrence of Y is independently OH, COOR 3 , or COOH. 17. The compound of claim 16, wherein each R 1 or R 2 is the same or different (C j -C 6 )alkyl group. 18. A compound of the formula Ic: Ic or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein: (a) each occurrence of m is an independent integer ranging from 1 to 9; (b) x is 2, 3, or 4; (c) V is: 19. A compound according to claim 1, having the formula 5-[2-(5-hydroxy-4,4-dimethyl-pentyloxy)-ethoxy]-2,2-dimethyl-pentan-l-ol or 4-[3-(3,3-Dimethyl-4-oxo-butoxy)-propoxy]-2,2-dimethyl-butyric acid. 20. A compoimd of the formula II: II or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) R 1 and R 2 are independently (C j -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alk nyl, phenyl, or benzyl; or R 1 , R 2 , and the carbon to which they are both attached are taken together to form a (C 3 -C 7 )cycloalkyl group; (b) each occurrence of n is independently an integer ranging from 1 to 5; (c) each occurrence of m is independently an integer ranging from 0 to 4; (d) W 1 and W 2 are independently CH 2 OH, COOH, CHO, OCOR 3 , COOR 3 , SO 3 H, wherein: (i) R 3 is (C t -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (C j -C^alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (C [ -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, Cj-C 6 alkoxy, or phenyl groups, (iii) each occurrence of R 5 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl. 21. A compound of the formula Ila: Ila or a pharmaceutically acceptable salt, hydrate, solvate, clatlirate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein: (a) R 1 and R 2 are OH, COOH, CHO, COOR 7 , SO 3 H, wherein: (i) R 7 is (C ! -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, orbenzyl and is unsubstituted or substituted with one or more halo, OH, (C 1 -C 6 )alkoxy, or phenyl groups, (ii) each occurrence of R 8 is independently H, (C j -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, - alkoxy, or phenyl groups, (iii) each occurrence of R 9 is independently H, (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl; (b) R 3 and R 4 are ( - alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl; (c) R 5 andR 6 areH, halogen, ( -C alkyl, (C^C^alkoxy, (C 6 )aryloxy, CN, or O 2 N(R 5 ) 2 where R 5 is H, ( -C^alkyl, phenyl, or benzyl; (d) each occurrence of m is independently an integer ranging from 1 to 5; (e) each occurrence of n is independently an integer ranging from 0 to 4; and (f) C* 1 and C* 2 each represent independent chiral-carbon centers. 22. The compound of claim 21 wherein C* 1 is a chiral-carbon center of the stereochemical configuration R or substantially R. 23. The compound of claim 21 wherein C* 1 is a chiral-center of the stereochemical configuration S or substantially S. 24. The compound of claim 21 wherein C* 2 is a chiral-carbon center of the stereochemical configuration R or substantially R. 25. The compound of claim 21 wherein C* 2 is a chiral-center of the stereochemical configuration S or substantially S. 26. A compound of the formula III: III or a pharmaceutically acceptable salt, hydrate, solvate, clatlirate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) each occurrence of Z is independently CH 2 , CH=CH, or phenyl, where each occurrence of m is independently an integer ranging from 1 to 5, but when Z is phenyl then its associated m is 1 ; (b) G is (CH 2 ) X , where x is an integer ranging from 1 to 4, CH 2 CH=CHCH 2 , CH=CH, CH 2 -phenyl-CH 2 , or phenyl; (c) W 1 and W 2 are independently C(R l )Q )-(CΗ. 2 ) n —Y, where n is an integer ranging from 0 to 4; (d) each occurrence of R 1 or R 2 is independently (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl or R 1 and R 2 are both H; (e) each occurrence of R 6 or R 7 is independently H, (C C 6 )alkyl, or R 6 and R 7 can be taken together to form a carbonyl group; (f) Y is OH, COOH, CHO, COOR 3 , SO 3 H, wherein: (i) R 3 is (Cι-C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, orbenzyl and is unsubstituted or substituted with one or more halo, OH, ( -C^alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (C j -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, - alkoxy, or phenyl groups, (iii) each occurrence of R 5 is independently H, ( -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl; and (g) each occurrence of p is independently 0 or 1 where the broken line represents an optional presence of one or more additional carbon-carbon bonds that when present complete one or more carbon-carbon double bonds. 27. The compound of claim 26, wherein W 1 and W 2 are independent C(R I )(R 2 )-(CH 2 ) n -Y groups and each occurrence of Y is independently OH, COOR 3 , or COOH. 28. The compound of claim 26, wherein p is 0. 29. The compound of claim 26, wherein p is 1. 30. The compound of claim 26, wherein each occurrence of R 6 and R 7 is H. 31. A compound of the formula Ilia: Ilia or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof, wherein (a) each occurrence of m is independently an integer ranging from 1 to 5; (b) x is an integer ranging from 1 to 4; (c) W 1 and W 2 are independently C(R 1 )(R 2 )-(CH 2 ) n -Y, where n is an integer ranging from 0 to 4; (d) each occurrence of R 1 or R 2 is independently (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl; (e) Y is OH, COOH, CHO, COOR 3 , SO 3 H, wherein: (i) R 3 is ( -C^alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, orbenzyl and is unsubstituted or substituted with one or more halo, OH, (C j -C^alkoxy, or phenyl groups, (ii) each occurrence of R 4 is independently H, (C j -C^alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, - alkoxy, or phenyl groups, (iii) each occurrence of R 5 is independently H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl; and (f) each occurrence of p is independently 0 or 1. 32. The compound of claim 31 , wherein W 1 and W 2 are independent C(R X )(R 2 )-Y Q groups and each occurrence of Y is independently (CH 2 ) n OH, (CH^COOR 3 , or (CH 2 ) n COOH. 33. The compound of claim 31 , wherein p is 0. 34. The compound of claim 31 , wherem p is 1. 5 35. A compound of the formula: 1-1 4-[4-(3-Hydroxy-3-methyl-butane-l-sulfmylmethyl)-phenylmethanesulfinyl]-2- methyl-butan-2-ol; 1-2 4-[4-(4-Hydroxy-3,3-dimethyl-butane-l-sulfinylmethyl)-phenylmethanesulfinyl]-2, 0 2-dimethyl-butan-l-ol; 1-3 4-[4-(3-Carboxy-3-methyl-butane-l-sulfinylmethyl)-phenylmethanesulfinyl]-2,2- dimethyl-butyric acid; 1-4 4- [4-(3 ,3 -Dimethyl-4-oxo-butane- 1 -sulfinylmethyl)-phenylmethanesulfinyl] -2,2- dimethyl-butyraldehyde; 5 1-5 4- [4-(3 -Methoxycarbonyl-3 -methyl-butane- 1 -sulfinylmethyl)-phenylmethanesulfin yl]- 2,2-dimethyl-butyric acid methyl ester; 1-6 2,2-Dimethyl-4-[4-(3-methyl-3-phenoxycarbonyl-butane-l-sulfinylmethyl)- phenylmethanesulfinyl] -butyric acid phenyl ester; 1-7 4-[4-(3-Benzyloxycarbonyl-3-methyl-butylsulfanylmethyl)-benzylsulfanyl]-2,2- 0 dimethyl-butyric acid benzyl ester; 1-8 2-Methyl-4-[4-(3-methyl-3-sulfo-butylsulfanylmethyl)-benzylsulfanyl]-butane-2- sulfonic acid; 1-9 Phosphoric acid mono- {1,1 -dimethyl-3-[4-(3-methyl-3-phosphonooxy- butylsulfanylmethyl)-benzylsulfanyl] -propyl} ester; 5 1-10 4-[4-(3-Hydroxy-3-methyl-butylsulfanyl)-phenylsulfanyl]-2-methyl-butan-2-ol; 1-11 4-[4-(4-Hydroxy-3,3-dimethyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butan- l-ol; 1-12 4-[4-(3-Carboxy-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyric acid; 1-13 4-[4-(3,3-Dimethyl-4-oxo-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl- butyraldehyde; 1-14 4-[4-(3-Methoxycarbonyl-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl- butyric acid methyl ester; 1-15 2,2-Dimethyl-4-[4-(3-methyl-3-ρhenoxycarbonyl-butylsulfanyl)-phenylsulfanyl]- butyric acid phenyl ester; 1-16 4-[4-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl- butyric acid benzyl ester; 1-17 2-Methyl-4-[4-(3-methyl-3-sulfo-butylsulfanyl)-phenylsulfanyl]-butane-2-sulfonic acid; 1-18 Phosphoric acid mono-{l,l-dimethyl-3-[4-(3-methyl-3-phosphonooxy- butylsulfanyl)-phenylsulfanyl] -propyl} ester; Ib-1 4-[3-(3-Hydroxy-3-methyl-butane-l-sulfinyl)-propane-l-sulfinyl]-2-methyl- butan-2-ol; Ib-2 4- [3 -(4-Hydroxy-3 ,3 -dimethyl-butane- 1 -sulfinyl)-propane- 1 - sulfinyl] - 2,2-dimethyl-butan- 1 -ol; Ib-3 4-[3-(3-Carboxy-3-methyl-butane- 1 -sulfinyl)-propane- 1 -sulfinyl]-2,2-dimethyl- butyric acid; Ib-4 4-[3-(3,3-Dimethyl-4-oxo-butane-l-sulfinyl)-propane-l-sulfinyl]-2,2- dimethyl-butyraldehyde; Ib-5 4-[3-(3-Methoxycarbonyl-3-methyl-butane-l-sulfinyl)-propane-l-sulfinyl]-2,2- dimethyl-butyric acid methyl ester; Ib-6 2,2-Dimethyl-4-[3 -(3 -methyl-3 -phenoxycarbonyl-butane- 1 -sulfmyl)-propane- 1 - sulfinyl] -butyric acid phenyl ester; Ib-7 4-[3-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl- butyric acid benzyl ester; Ib-8 2-Methyl-4-[3-(3-methyl-3-sulfo-butane-l-sulfmyl)-propane-l-sulfinyl]-butane- 2-sulfonic acid; Ib-9 Phosphoric acid mono- {1 ,l-dimethyl-3-[3-(3-methyl-3-phosphonooxy-butane-l- sulfinyl)-ρropane-l-sulfinyl]-propyl} ester; Ib-10 5-{l,l-Dimethyl-3-[3-(3-methyl-3-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-di one} -butane- 1 -sulfinyl)-propane- 1 -sulfinyl] -propyl} -3 ,3 a-dihydro-2H-thieno [3 ,2-c ]pyridine-4,6-dione; Ib-11 5- { 1 , 1 -Dimethyl-3-[3-(3-methyl-3- {3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dit hione}-butane-l-sulfinyl)-propane-l-sulfinyl]-propyl}-3,3a-dihydro-2H-thieno[3,2 -c]pyridine-4,6-dithione; Ib-12 4-[3-(3-Cyanocarbamoyl-3-methyl-butane-l-sulfinyl)-propane-l-sulfinyl]-2,2-dim ethyl-butyrcyanimide; Ib-13 Phosphoramidic acid mono-(3-{3-[3-(amino-hydroxy-phosphoryloxy)- 3 -methyl-butane- 1 -sulfinyl]-propane-l -sulfinyl} -1,1 -dimethyl-propyl) ester Ib-14 3 -(Amino-hydroxy-phosphoryloxy)-3 -methyl- 1 - [3 -(3 - {amino -hydroxy-phosphoryloxy} -3-methyl-butane- 1 -sulfmyl)-propane- 1 -sulfinyl]-butane; Ib-15 1- {1,1 -Dimethyl-3 - [3 -(3 -methyl-3 - { 1 H-tetrazol- 1 -yl} -butane- 1 -sulfinyl)-propane- 1 -sulfinyl]-propyl} - 1 H-tetrazole; Ib-16 l-{l,l-Dimethyl-3-[3-(3-methyl-3-{lH-tetrazol-5-yl}-butane-l-sulfinyl)-propane- 1 -sulfinyl] -propyl} - 1 H-tetrazole; Ib-17 5-{l,l-Dimethyl-3-[3-(3-{Isoxazol-3-ol-5-yl}-3-methyl-butane-l-sulfmyl)- propane- 1 -sulfinyl]-propyl} -isoxazol-3 -ol; Ib-18 4-{l,l-Dimethyl-3-[3-(3-{Isoxazol-3-ol-4-yl}-3-methyl-butane-l- sulfinyl)- propane- 1 -sulfinyl]-proρyl} -isoxazol-3-ol; Ib-19 3-{l,l-Dimethyl-3-[3-(3-{5-hydroxy-pyran-4-one-3-yl}-3-methyl-butane-l- sulfinyl)-propane- 1 -sulfinyl] -propyl} -5-hydroxy-pyran-4-one; Ib-20 2- { 1 , l-Dimethyl-3-[3-(3- {5-hydroxy-ρyran-4-one-2-yl} -3-methyl-butane-l - sulfinyl)-proρane-l-sulfinyl]-propyl}-5-hydroxy-ρyran-4-one; Ib-21 1 -Ethyl-3-(3- {3-[3-(3-ethyl-2,5-dithioxo-imidazolidin-l -yl)-3 -methyl-butane- 1 - sulfinyl] -propane- 1 -sulfinyl} -1,1 -dimethyl-propyl)-imidazolidine-2,4-dione; Ib-22 3- { l,l-Dimethyl-3-[3-(3- { l-ethyl-imidazolidine-2,4-dione-3-yl}-3-methyl-butane- 1 -sulfinyl)-propane- 1 -sulfinyl] -propyl} - 1 -ethyl-imidazolidine-2,4-dione; Ib-23 3- {l,l-Dimethyl-3-[3-(3-{l-ethyl-imidazolidine-2-one-4-thione-3-yl}- 3 -methyl-butane- 1 -sulfinyl)-propane- 1 -sulfinyl] -propyl} - 1 -ethyl- imidazolidine-2- one-4-thione; Ib-24 3-{l,l-Dimethyl-3-[3-(3-{l-ethyl-imidazolidine-4-one-2-thione-3-yl}-3-methyl- butane- 1 -sulfinyl)-propane-l -sulfinyl] -propyl} - 1 -ethyl-imidazolidine-4-one-2- thione; Ib-25 5 -[3 -(5 -Hydroxy-3 ,3 -dimethyl-pentylsulfanyl)-propylsulfanyl] -3,3 -dimethyl- pentan-1- ol; Ib-26 5-[3-(4-Carboxy-3,3-dimethyl-butane-l-sulfinyl)-ρropane-l-sulfinyl]-3,3- dimethyl-pentanoic acid; Ib-27 5-[3-(3,3-Dimethyl-5-oxo-ρentane-l-sulfinyl)-propane-l-sulfinyl]-3,3-dimethyl- pentanal; Ib-28 5- [3 -(4-Methoxycarbonyl-3 ,3 -dimethyl-butane- 1 -sulfinyl)-propane- 1 -sulfinyl] -3,3- dimethyl-pentanoic acid methyl ester; Ib-29 3,3-Dimethyl-5-[3-(3-methyl-3-phenoxycarbonyl-butane-l-sulfinyl)-propane-l- sulfinyl] -pentanoic acid phenyl ester; Ib-30 5 -[3 -(3-Benzyloxycarbonyl-3 -methyl-butane- 1 -sulfinyl)-propane- 1 -sulfinyl] -3,3- dimethyl-pentanoic acid benzyl ester; Ib-31 4-[3-(3,3-Dimethyl-4-sulfo-butane-l-sulfinyl)-proρane-l-sulfinyl]-2,2-dimethyl- butane-1-sulfonic acid; Ib-32 Phosphoric acid mono- {4- [3 -(3 ,3 -dimethyl-4-phosphonooxy-butane- 1 -sulfinyl)- propane-l-sulfinyl]-2,2-dimethyl-butyl} ester; Ib-33 5-{4-[3-(3,3-Dimethyl-4-{3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione}-butan e- 1 -sulfinyl)-propane- 1 -sulfinyl] -2,2-dimethyl-butyl} -3 ,3 a-dihydro-2H-thieno [3 ,2-c]pyridine-4,6-dione; Ib-34 5-{4-[3-(3,3-Dimethyl-4-{3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-bu tane- 1 -sulfinyl)-propane- 1 -sulfinyl]-2,2-dimethyl-butyl} -3 ,3 a-dihydro-2H- thieno[3,2-c]pyridine-4,6-dithione; Ib-35 5-[3-(4-Cyanocarbamoyl-3,3-dimethyl-butane-l-sulfinyl)-propane-l-sulfinyl]-3,3- dimethyl-pentanoic acid cyanamide; Ib-36 Phosphoramidic acid mono-(4- {3-[4-(amino-hydroxy-phosphoryloxy)-3 ,3- dimethyl-butane- 1 -sulfinyl] -propane- 1 -sulfinyl} -2,2-dimethyl-butyl) ester; Ib-37 l-{4-[3-(3,3-Dimethyl-4-{tetrazol-l-yl}-butane-l-sulfinyl)-propane-l-sulfmyl]-2,2 -dimethyl-butyl} -1 H-tetrazole; Ib-38 l-{4-[3-(3,3-Dimethyl-4-{tetrazol-5-yl}-butane-l-sulfmyl)-ρroρane-l-sulfιnyl]-2,2 -dimethyl-butyl} - lH-tetrazole; Ib-39 5- {4-[3-(3,3-Dimethyl-4- {isoxazol-3-ol-5-yl} -butane- 1 -sulfinyl)-propane-l -sulfϊny l]-2,2-dimethyl-butyl}-isoxazol-3-ol; Ib-40 4-{4-[3-(3,3-Dimethyl-4-{isoxazol-3-ol-4-yl}-butane-l-sulfinyl)-propane-l- sulfinyl] -2,2-dimethyl-butyl} -isoxazol-3 -ol; Ib-41 3-{4-[3-(3,3-Dimethyl-4-{5-hydroxy-pyran-4-one-3-yl}-butane-l- sulfinyl)- propane-l-sulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one; Ib-42 2- {4-[3-(3 ,3-Dimethyl-4- {5-hydroxy-pyran-4-one-2-yl} -butane- 1-sulfmyl)- propane-l-sulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one; Ib-43 3- {4-[3-(3 ,3-Dimethyl-4- {5-Hydroxy-pyran-4-one-2-yl} -butane- 1 -sulfinyl)- propane-l-sulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one; Ib-44 l-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dithioxo-imidazolidm-l-yl)-3,3-dimethyl-butane-l -sulfinyl]-propane-l-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione; Ib-45 l-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l- sulfinyl]-propane-l-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione; Ib-46 l-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l -sulfinyl]-propane-l-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dithione; Ib-47 l-Ethyl-3-(4-{3-[4-(3-ethyl-2-oxo-5-thio-imidazolidin-l-yl)-3,3-dimethyl- butane- 1 -sulfinyl] -propane- 1 -sulfinyl} -2,2-dimethyl-butyl)-imidazolidine-2-one- 4-thione; Ib-48 l-Ethyl-3-(4-{3-[4-(3-ethyl-2-thioxo-5-oxo-imidazolidin-l-yl)- 3,3- dimethyl- butane- 1 -sulfinyl]-propane- 1 -sulfinyl} -2,2-dimethyl-butyl)-imidazolidine-2- thione-4-one; Ib-49 4-[2-(3-Hydroxy-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2-methyl-butan-2-ol; Ib-50 4-[2-(4-Hydroxy-3,3-dimethyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl- butan-1-ol; Ib-51 4-[2-(3-Carboxy-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid; Ib-52 2-Methyl-4-[2-(3-methyl-3-sulfo-butane-l-sulfinyl)-ethanesulfinyl]-butane-2- sulfonic acid; Ib-53 4-[2-(3,3-Dimethyl-4-oxo-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl- butyraldehyde; Ib-54 4-[2-(3-Methoxycarbonyl-3-methyl-butane-l-sulfmyl)-ethanesulfinyl]-2,2- dimethyl-butyric acid methyl ester; Ib-55 2,2-Dimethyl-4-[2-(3-methyl-3-phenoxycarbonyl-butane-l-sulfinyl)- ethanesulfinyl] -butyric acid phenyl ester; Ib-56 4-[2-(3-Benzyloxycarbonyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2- dimethyl-butyric acid benzyl ester; Ib-57 Phosphoric acid mono-{l,l-dimethyl-3-[2-(3-methyl-3-phosphonooxy-butane-l- sulfinyl)-ethanesulfinyl] -propyl} ester; Ib-58 5-[3 -(4-Hydroxy-4-methyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl] -2-methyl- pentan-2-ol; Ib-59 5-[3-(5-Hydroxy-4,4-dimethyl-pentane-l-sulfinyl)-proρane-l-sulfinyl]-2,2- dimethyl-pentan- 1 -ol; Ib-60 5-[3-(4-Carboxy-4-methyl-pentane-l-sulfinyl)-propane-l-sulfmyl]-2,2-dimethyl- pentanoic acid; Ib-61 5-[3-(4,4-Dimethyl-5-oxo-pentane-l-sulfinyl)-propane-l-sulfinyl]-2,2-dimethyl- pentanal; Ib-62 5 -[3 -(4-Methoxycarbonyl-4-methyl-pentane- 1 -sulfinyl)-ρropane- 1 -sulfinyl] -2,2- dimethyl-pentanoic acid methyl ester; Ib-63 3,3 -Dimethyl-6-[3 -(4-methyl-4-phenoxycarbonyl-pentane- 1 -sulfinyl)-propane- 1 - sulfinyl] -hexanoic acid phenyl ester; Ib-64 6-[3-(4-Benzyloxycarbonyl-4-methyl-ρentane-l-sulfinyl)-propane-l-sulfinyl]-3,3- dimethyl-hexanoic acid benzyl ester; Ib-65 2-Methyl-5-[3-(4-methyl-4-sulfo-pentane-l-sulfinyl)-propane-l-sulfmyl]-pentane- 2-sulfonic acid; Ib-66 Phosphoric acid mono-{l,l-dimethyl-4-[3-(4-methyl-4-phosρhonooxy-pentane-l- sulfinyl)-propane-l -sulfinyl]-butyl} ester; 5 Ib-67 5-{l,l-Dimethyl-4-[3-(4-methyl-4-{3,3a-dihydro-2H-thieno[3,2-c]-4,6-dioxo- pyridine-5-yl}-pentane-l-sulfmyl)-propane-l-sulfinyl]-butyl}-3,3a-dihydro-2H- tliieno[3,2-c]pyridine-4,6-dione; Ib-68 5- { 1 ,1 -Dimethyl-4-[3-(4-methyl-4- {3,3a-dihydro-2H-thieno[3,2-c]-4,6-dithioxo- pyridine-5-yl}-pentane-l-sulfinyl)-propane-l-sulfinyl]-butyl}-3,3a-dihydro-2H- 1 o thieno[3 ,2-c]pyridine-4,6-dithione; Ib-69 5-[3-(4-Cyanocarbamoyl-4-methyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-2,2- dimethyl-pentanoic acid cyanamide; Ib-70 Phosphoramidic acid mono-(4- {3-[4-(amino-hydroxy-phosphoryloxy)- 4-methyl-pentane- 1 -sulfinyl] -propane- 1 -sulfinyl} -1,1 -dimethyl-butyl) ester; 15 Ib-71 4-(Amino-hydroxy-phosphoryloxy)-4-methyl-l-[3-(4-{amino-hydroxy-phosphoryl oxy} -4-methyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl]-ρentane; Ib-72 5-(l , 1 -Dimethyl-4- {3-[4-methyl-4-(3H-[l ,2,3]triazol-l -yl)-pentane-l -sulfinyl]- propane- 1 -sulfinyl} -butyl)- lH-tetrazole; Ib-73 5-(l,l-Dimethyl-4-{3-[4-methyl-4-(3H-[l,2,3]triazol-4-yl)-pentane-l-sulfmyl]- 20 propane- 1 -sulfinyl} -butyl)- lH-tetrazole; Ib-74 5- { 1 , 1 -Dimethyl-4-[3-(4- {isoxazol-3-ol-5-yl} -4-methyl-pentane- l-sulfinyl)-propan e- 1 -sulfinyl] -butyl} -isoxazol-3-ol; Ib-75 4- { 1 , 1 -Dimethyl-4-[3-(4- {isoxazol-3 -ol-4-yl} -4-methyl-pentane- 1 -sulfinyl)- propane-l-sulfinyl]-butyl}-isoxazol-3-ol; ^ Ib-76 3- { 1 , 1 -Dimethyl-4-[3-(4- {5-hydroxy-4-oxo-pyran-3-yl} -4-methyl-pentane-l - sulfinyl)-propane-l -sulfmyl]-butyl} -5-hydroxy-pyran-4-one; Ib-77 2- { 1 , 1 -Dimethyl-4-[3-(4- {5-hydroxy-4-oxo-pyran-2-yl} -4-methyl-pentane- 1 -sulfin yl)-propane-l-sulfinyl]-butyl}-5-hydroxy-pyran-4-one; Ib-78 3- { 1 , 1 -Dimethyl-4-[3 -(4- { 1 -ethyl-2,4-dioxo-imidazolidine-3-yl} -4-methyl-pentane 30 - 1 -sulfinyl)-propane- 1 -sulfinyl] -butyl} - 1 -ethyl-imidazolidine-2,4-dione; Ib-79 3- { 1 , 1 -Dimethyl-4-[3-(4- {1 -ethyl-2,4-dithioxo-imidazolidine-3-yl} -4-methyl- pentane-l-sulfinyl)-propane-l-sulfinyl]-butyl}-l-ethyl-imidazolidine-2,4-dithione; Ib-80 3- { 1 , 1 -Dimethyl-4-[3-(4- { 1 -ethyl-2-thixoxo-4-oxo-imidazolidine-3-yl} -4- methyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl] -butyl} - 1 -ethyl-imidazolidine-2- thione-4-one; Ib-81 3- { 1 , 1 -Dimethyl-4-[3-(4- { l-ethyl-2-one-4-thioxo-imidazolidine-3-yl} -4- methyl-ρentane-1 -sulfinyl)-propane- 1 -sulfinyl]- butyl} - 1 -ethyl-imidazolidine-2- one-4-thione; Ib-81 5-[2-(5-Hydroxy-3,3-dimethyl-pentane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl- pentan-1-ol; Ib-82 5-[2-(4-Carboxy-3,3-dimethyl-butane-l-sulfϊnyl)-ethanesulfinyl]-3,3-dimethyl- pentanoic acid; Ib-83 5-[2-(3,3-Dimethyl-5-oxo-pentane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentan al; Ib-84 5 - [2-(4-Methoxycarbonyl-3 ,3 -dimethyl-butane- 1 -sulfmyl)-ethanesulfinyl] -3,3- dimethyl-pentanoic acid methyl ester; Ib-85 5-[2-(3,3-Dimethyl-4-phenoxycarbonyl-butane-l-sulfinyl)-ethanesulfϊnyl]-3,3- dimethyl-pentanoic acid phenyl ester; Ib-86 5-[2-(4-Benzyloxycarbonyl-3,3-dimethyl-butane-l-sulfinyl)-ethanesulfinyl]-3,3- dimethyl-pentanoic acid benzyl ester; Ib-87 4-[2-(3,3-Dimethyl-4-sulfo-butane-l-sulfmyl)-ethanesulfmyl]-2,2-dimethyl- butane- 1-sulfonic acid; Ib-88 Phosphoric acid mono-{4-[2-(3,3-dimethyl-4-phosphonooxy-butane-l-sulfinyl)-ethanesulfinyl]- 2,2-dimethyl-butyl} ester; Ib-89 5- {4-[2-(3,3-Dimethyl-4- {3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridine-5-yl}- butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-3,3a-dihydro-2H-thieno [3 ,2-c]pyridine-4,6-dione; Ib-90 5-{4-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]ρyridine-5- yl}-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-3,3a-dihydro-2H-thieno [3 ,2-c]pyridine-4,6-dithione; Ib-91 5-[2-(4-Cyanocarbamoyl-3,3-dimethyl-butane- 1 -sulfinyl)-ethanesulfinyl]-3,3- dimethyl-pentanoic acid cyanamide; Ib-92 Phosphoramidic acid mono-(4- {2-[4-(amino-hydroxy- phosphoryloxy)- 3,3-dimethyl-butane-l-sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl) ester; Ib-93 1 -[2-(3,3-Dimethyl-4 {amino-hydroxy-phosphoryloxy} -butane- 1 -sulfinyl)-ethanesu lfinyl] -3,3 -dimethyl-4 {amino-hydroxy-phosphoryloxy} -butane; Ib-94 5-{4-[2-(3,3-Dimethyl-4-tetrazol-5-yl-butane-l-sulfmyl)-ethanesulfinyl]-2,2- dimethyl-butyl} - lH-tetrazole; Ib-95 5- {4-[2-(3 ,3 -Dimethyl-4-tetrazol- 1 -yl-butane- 1 -sulfinyl)-ethanesulfmyl]-2,2- dimethyl-butyl} - 1 H-tetrazole; Ib-96 5-{4-[2-(3,3-Dimethyl-4-isoxazol-3-ol-5-yl-butane-l-sulfmyl)-ethanesulfmyl]-2,2- dimethyl-butyl} -isoxazol-3-ol; Ib-97 4- {4-[2-(3,3-Dimethyl-4-isoxazol-3-ol-4-yl-butane-l -sulfmyl)-ethanesulfinyl] -2,2- dimethyl-butyl} -isoxazol-3 -ol; Ib-98 3-{4-[2-(3,3-Dimethyl-4-{5-hydroxy-4-oxy-pyran-3-yl}-butane-l-sulfinyl)- ethanesulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one; Ib-99 2-{4-[2-(3,3-Dimethyl-4-{5-hydroxy-4-oxy-pyran-3-yl}-butane-l-sulfmyl)- ethanesulfinyl]-2,2-dimetlιyl-butyl}-5-hydroxy-pyran-4-one; Ib-100 2- {4-[2-(3 ,3-Dimethyl-4- {5-hydroxy-4-oxy-pyran-2-yl} -butane- 1 -sulfinyl)-ethanes ulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one; Ib-101 3- {4-[2-(3 ,3 -Dimethyl-4- { 1 -Ethyl-2,4-dithioxo-imidazolidine-3 -yl} -butane-1 - sulfϊnyl)-ethanesulfinyl] -2,2-dimethyl-butyl} - 1 -ethyl-imidazoIidine-2,4-dithione; Ib-102 l-Ethyl-3-(4-{2-[4-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l -sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione; Ib-103 l-Ethyl-3-(4-{2-[4-(3-ethyl-2,5-dioxo-imidazolidin-l-yl)-3,3-dimethyl-butane-l- sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione; Ib-104 l-Ethyl-3-(4-{2-[4-(3-ethyl-2-thioxo-5-oxo-imidazolidin-l-yl)-3,3- dimemyl-butane-l-sulfmyl]-ethanesulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2- thione-4-one; Ib-105 l-Ethyl-3-(4-{2-[4-(3-ethyl-2-oxo-5-thioxo-imidazolidin-l-yl)- 3,3-dimethyl- butane- l-sulfmyl]-ethanesulfmyl}-2,2-dimethyl-butyl)- imidazolidine-2-one- 4-thione; Ib-106 6- [2-(6-Hydroxy-3 ,3 -dimethyl-hexane- 1 -sulfinyl)-ethanesulfmyl] -4,4-dimethyl- hexan-1-ol; Ib-107 6-[2-(5-Carboxy-3 ,3 -dimethyl-pentane- 1 -sulfinyl)-ethanesulfinyl]-4,4-dimethyl- hexanoic acid; Ib-108 6- [2-(3 ,3 -Dimethyl-6-oxo-hexane- 1 -sulfϊnyl)-ethanesulιιnyl]-4,4-dimethyl-hexanal Ib-109 6-[2-(5-Methoxycarbonyl-3,3-dimethyl-pentane- 1 -sulfinyl)-ethanesulfinyl]-4,4- dimethyl-hexanoic acid methyl ester; Ib-110 6-[2-(3,3-Dimethyl-5-phenoxycarbonyl-pentane-l-sulfinyl)-ethanesulfinyl]-4,4- dimethyl-hexanoic acid phenyl ester; Ib-111 6-[2-(5-Benzyloxycarbonyl-3,3-dimethyl-pentane-l-sulfinyl)-ethanesulfinyl]-4,4- dimethyl-hexanoic acid benzyl ester; Ib-112 5-[2-(3,3-Dimethyl-5-sulfo-pentane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl- pentane-1-sulfonic acid; Ib-113 Phosphoric acid mono-{5-[2-(3,3-dimethyl-5-phosphonooxy-pentane-l- sulfinyl)-ethanesulfinyl] -3,3 -dimethyl-pentyl} ester; Ib-114 5- {5-[2-(3,3-Dimethyl-4- {3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl}- pentane-l-sulfinyl)-ethanesulfmyl]-3,3-dimethyl-pentyl}-3,3a-dihydro-2H-thieno [3,2-c] pyridine-4,6-dione; Ib-115 5- {5-[2-(3,3-Dimethyl-4- {3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl }-ρentane-l-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-ρentyl}-3,3a-dihydro-2H- thieno[3,2-c]pyridine-4,6-dithione; Ib-116 6- [2-(5 -Cyanocarbamoyl-3 ,3 -dimethyl-pentane- 1 -sulfinyl)-ethanesulfmyl] -4,4- dimethyl- hexanoic acid cyanimide; Ib-117 Phosphoramidic acid mono-(5-{2-[5-(amino-hydroxy-phosphoryloxy)-3,3-dimethyl-pentane-l-sulfinyl]- ethanesulfinyl} -3,3-dimethyl-pentyl) ester; o Ib-118 1 -[2-(3 ,3-Dimethyl-5- {amino-hydroxy-phosphoryloxy} -pentane- 1 -sulfmyl)-ethane sulfinyl]-3,3-dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane; Ib-119 4-[2-(4-Hydroxy-3,3-dimethyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl- butan-1-ol; Ib-120 4-[2-(3-Carboxy-3-methyl-butane-l-sulfϊnyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid; 5 Ib-121 4-[2-(3,3-Dimethyl-4-oxo-butane-l-sulfinyl)-ethanesulfmyl]-2,2-dimethyl- butyraldehyde; Ib-122 4-[2-(3-Methoxycarbonyl-3-methyl-butane-l-sulfmyl)-ethanesulfmyl]-2,2- imethyl-butyric acid methyl ester; 0 Ib-123 2,2-Dimethyl-4-[2-(3-methyl-3-phenoxycarbonyl-butane-l-sulfϊnyl)- thanesulfinyl] -butyric acid phenyl ester; Ib-124 4-[2-(3-Benzyloxycarbonyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2- dimethyl-butyric acid benzyl ester; Ib-125 2-Methyl-4-[2-(3-methyl-3-sulfo-butane-l-sulfmyl)-ethanesulfmyl]-butane-2- sulfonic acid; 5 Ib-126 Phosphoric acid mono-{l,l-dimethyl-3-[2-(3-methyl-3-phosphonooxy- utane-l-sulfinyl)-ethanesulfinyl]-propyl} ester; Ib-127 5-{l,l-Dimethyl-3-[2 3-methyl-3-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c] yridine-5 -yl} -butane- 1 -sulfinyl)-ethanesulfinyl] -propyl} -3 ,3 a-dihydro-2H-thieno[3 ,2-c]pyridine-4,6-dione; 0 Ib-128 5-{l,l-Dimethyl-3-[2-(3-methyl-3-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c] yridine-5-yl}-butane-l-sulfinyl)-ethanesulfinyl]-propyl}-3,3a-dihydro-2H-thieno 3,2-c]pyridine-4,6- ithione; Ib-129 4-[2-(3-Cyanocarbamoyl-3-methyl-butane-l-sulfinyl)-ethanesulfinyl]-2,2-dimethyl -butyrcyanimide; 5 Ib-130 Phosphoramidic acid mono-(3-{2-[3-(amino-hydroxy-phosphoryloxy)-3- ethyl-butane-1 -sulfmyl]-ethanesulfinyl} -1,1 -dimethyl-propyl) ester; Ib-131 l-[2-(3,3-Dimethyl-4-{amino-hydroxy-phosphoryloxy}-butane-l-sulfinyl)-ethanes ulfinyl]-3,3-dimethyl-4-{amino-hydroxy-phosphoryloxy}-butane; Ib-132 l-{5-[2-(3,3-Dimethyl-5-{tetrazol-l-yl}-pentane-l-sulfinyl)-ethylsulfanyl]-3,3-dim ethyl-pentyl} - 1 H-tetrazole; Ib-133 5-{5-[2-(3,3-Dimethyl-5-{tetrazol-5-yl}-pentane-l-sulfinyl)-ethylsulfanyl]-3,3-dim ethyl-pentyl} - lH-tetrazole; Ib-134 5-{5-[2-(3,3-Dimethyl-5-(isoxazol-3-ol-5-yl}-pentane-l-sulfinyl)-ethanesulfmyl]- ,3- imethyl-pentyl} -isoxazol-3-ol; Ib-135 4-{5-[2-(3,3-Dimethyl-5-(isoxazol-3-ol-4-yl}-pentane-l-sulfinyl)-ethanesulfϊnyl]- 3,3- imethyl-pentyl} -isoxazol-3 -ol; o Ib-136 2- {5-[2-(3,3-Dimethyl-5- {5-Hydroxy-4-oxy-pyran-3-yl} -pentane-1 -sulfmyl)- ethanesulfinyl]-3,3-dimethyl-pentyl}-5-hydroxy-pyran-4-one; Ib-137 2-{5-[2-(3,3-Dimethyl-5-{5-Hydroxy~4-oxy-pyran-2-yl}-pentane-l-sulfinyl)- thanesulfinyl]-3,3-dimethyl-pentyl}-5-hydroxy-pyran-4-one; Ib-138 3-{5-[2-(3,3-Dimethyl-5-{5-Hydroxy~4-oxy-pyran-3-yl}-pentane-l-sulfinyl)- ethanesulfinyl]-3,3-dimetnyl-pentyl}-5-hydroxy-pyran-4-one; Ib-139 l-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-pentane- l-sulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dione; Ib-140 l-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dioxo-imidazolidin-l-yl)-3,3-dimethyl-pentane-l- sulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dione; 0 Ib-141 l-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dithioxo-imidazolidin-l-yl)-3,3-dimethyl-pentane- l- ulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dithione; Ib-142 l-Ethyl-3-(5-{2-[5-(3-ethyl-2-thioxo-5-oxo-imidazolidin-l-yl)-3,3- dimethyl- pentane- 1 -ulfinyl] -ethanesulfinyl} -3 ,3 -dimethyl-pentyl)-imidazolidine-2-thione-4- one; Ib-143 l-Ethyl-3-(5-{2-[5-(3-ethyl-2-oxo-5-thioxo-imidazolidin-l-yl)-3,3-dimethyl- 5 pentane- 1 -sulfinyl]- ethanesulfinyl} -3 ,3 -dimethyl-pentyl)-imidazolidine-2-one- 4-thione; Ib-144 6- [3 -(5 -Carboxy-4,4-dimethyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl] -3 ,3 -dimethy 1-hexanoic acid; 0 Ib-145 6-[3-(4,4-Dimethyl-6-oxo-hexane-l-sulfinyl)-propane-l-sulfinyl]-3,3- dimethyl-hexanal; Ib-146 6-[3-(5-Methoxycarbonyl-4,4-dimethyl-pentane-l-sulfmyl)-propane-l- sulfinyl]- 3,3-dimethyl-hexanoic acid methyl ester; Ib-147 6-[3-(6-Hydroxy-4,4-dimethyl-hexane-l-sulfinyl)-propane-l-sulfmyl]-3,3-dimethy 1-hexan-l-ol; 5 Ib-148 6-[3-(4,4-Dimethyl-5-phenoxycarbonyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl]-3, 3-dimethyl-hexanoic acid phenyl ester; Ib-149 6-[3-(5 -Benzyloxycarbonyl-4,4-dimethyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl] - 3,3-dimethyl-hexanoic acid benzyl ester; Ib-150 5-(3-{2-[3-(3-Ethyl-2,6-dioxo-3,6-dihydro-2H-pyridin-l-yl)-3-methyl-butane-l- sulfinyl]-ethanesulfinyl} -1,1 -dimethyl-propyl)-3 ,3 a-dihydro-2H-thieno [3 ,2-c] pyridine-4,6-dione; Ib-151 3-(3,3a-Dihydro-2H-thieno[3,2-c]ρyridine-4,6-dithione)-3-methyl-l-[2-(3-{3,3a- Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-3-methyl-butane-l-sulfinyl)- ethanesulfinyl] -butane; Ib-152 4-[2-(3-Cyanocarbamoyl-3-methyl-butane-l-suIfinyl)-ethanesulfinyl]-2,2-dimethyl -cyanobutyramide; Ib-153 Phosphoramidic acid mono-(3-{2-[3- (amino-hydroxy-phosphoryloxy)- 3-methyl-butane-l-sulfinyl]-ethanesulfinyl}-l,l-dimethyl-propyl) ester; Ib-154 3-(Amino-hydroxy-phosphoryloxy)-3-methyl-l-[2-(3-{amino-hyroxy-phosphoylox y } -3 -methyl-butane- 1 -sulfinyl)-ethanesulfinyl] -butane; Ib-155 3-Methyl-3-tetrazol- 1 -yl-1 -[2-(3-methyl-3-tetrazol-l -yl-butane- 1 -sulfmyl)- ethanesulfinyl]-butane; Ib-156 3-Methyl-3- lH-tetrazol-5-yl- 1 -[2-(3 -methyl-3- lH-tetrazol-5-yl-butane- 1- sulfmyl)-ethanesulfmyl]-butane; Ib-157 5-[3-(4,4-Dimethyl-5-sulfo-pentane-l-sulfinyl)-propane-l-sulfmyl]-2,2-dimethyl- pentane- 1-sulfonic acid; Ib-158 Phosphoric acid mono-{5-[3-(4,4-dimethyl-5-phosphonooxy- pentane- 1-sulfinyl)- propane- 1 -sulfinyl]-2,2-dimethyl-pentyl} ester; Ib-159 l-[3-(5-{3,3a-Dihydro-2Η-thieno[3,2-c]ρyridine-4,6-dione}-4,4-Dimethyl-ρentane - 1 -sulfinyl)-propane- 1 -sulfinyl]-5-(3 ,3 a-Dihydro-2H-thieno[3 ,2-c]pyridine-4,6- dione)-4,4-dimethyl-pentane; Ib-160 l-[3-(5-{3,3a-Dihydro-2H-thieno[3,2-c]ρyridine-4,6-dithione}-4,4-Dimethyl- ρentane-l-sulfinyl)-propane-l-sulfinyl]-5-(3,3a-Dihydro-2H-thieno[3,2-c]pyridine- 4,6-dithione)-4,4-dimethyl-pentane; Ib-161 6-[3-(5 -Cyanocarbamoyl-4,4-dimethyl-pentane- 1 -sulfinyl)-propane- 1 -sulfinyl] -3,3 -dimethyl-hexanoic acid cyanamide; Ib-162 Phosphoramidic acid mono-[ 16-(amino-hydroxy-phosphoryloxy)-4,4, 15,15- tetramethyl-7,11-dioxo-hexadecyl] ester; Ib-163 l-[3-(4,4-Dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane-l-sulfinyl)-propan e-l-sulfinyl]-4,4-dimethyl-5-(amino-hydroxy-phosphoryloxy)-pentane; Ib-1 4 4,4-Dimethyl-5 -tetrazol- 1 -yl- 1 -[3-(4,4-dimethyl-5 -tetrazol- 1 -yl-pentane- 1 -sulfinyl) -propane- 1 -sulfinyl]-pentane; Ib-1 5 4,4-Dimethyl-5- lH-tetrazol-5-yl- 1 -[3-(4,4-dimethyl-5- lH-tetrazol-5-yl-pentane- 1 - sulfinyl)-propane-l-sulfmyl]-pentane; Ib-166 l-[3-(5-isoxazol-5-yl-4,4-dimethyl-pentane-l-sulfinyl)-propane-l-sulfmyl]-5- isoxazol-5-yl-4,4-dimethyl-hexane; Ib-167 l-[3-(5-isoxazol-4-yl-4,4-dimethyl-pentane-l-sulfinyl)-propane-l-sulfinyl]-5- isoxazol-4-yl-4,4-dimethyl-hexane; Ib-168 l-[3-(5-{5-Ηydroxy-4-oxo-4Η-pyran-3-yl}-4,4-dimethyl-pentane-l-sulfinyl)- propane- 1 -sulfinyl]-5-(5-hydroxy-4-oxo-4H-pyran-2-yl)-4,4- dimethyl-pentane; Ib-169 l-[3-(5-{5-Hydroxy-4-oxo-4H-pyran-2-yl}-4,4-dimethyl-ρentane-l-sulfinyl)- propane-l-sulfinyl]-5-(5-hydroxy-4-oxo-4H-pyran-2-yl)-4,4- dimethyl-pentane; Ib-170 l-[3-(5- {5 -Hydroxy-4-oxo-4H-pyran-3 -yl} -4,4-dimethyl-pentane- 1 -sulfinyl)- propane-l-sulfinyl]-5-(5-hydroxy-4-oxo-4H-pyran-3-yl)-4,4-dimethyl-pentane; Ib-171 1 -[3-(5- { 1 -ethyl-2,4-dithioxo-imidazolidinyl} -4,4-dimethyl-pentane- 1 -sulfmyl)- propane-l-sulfinyl]-5-(l-ethyl-2,4-dithioxo-imidazolidinyl)-4,4-dimethyl-pentane; Ib-172 l-[3-(5-{l-ethyl-2,4-ditlιioxo-imidazolidinyl}-4,4-dimethyl-pentane-l-sulfinyl)- propane-l-sulfinyl]-5-(l-ethyl-2,4-dioxo-imidazolidinyl)-4,4-dimethyl-pentane; Ib-173 1 - [3 -(5 - { 1 -ethyl-2 ,4-dioxo-imidazolidinyl} -4,4-dimethyl-pentane- 1 -sulfinyl)- propane- 1 -sulfinyl] -5 -( 1 -ethyl-2,4-dioxo-imidazolidinyl)-4,4-dimethyl-pentane; Ib-174 1 -[3-(5 - { 1 -ethyl-2-thioxo-imidazolidin-4-one} -4,4-dimethyl-pentane- 1 -sulfinyl)- propane- 1 -sulfinyl]-4-( 1 -ethyl-2-thioxo-imidazolidin-4-one)-4,4-dimethyl-pentane; Ib-175 l-[3-(5- { 1 -ethyl-4-thioxo-imidazolidin-2-one} -4,4-dimethyl-pentane- 1 -sulfinyl)- propane-l-sulfmyl]-5-(l-ethyl-4-thioxo-imidazolidin-2-one)-4,4-dimethyl-pentane; Ib-176 5-[2-(5 -Hydroxy-3 ,3 -dimethyl-pentane- 1 -sulfinyl)-ethanesulfinyl] -3,3- dimethyl-pentan- 1 -ol; Ic-1 2-[2-(3-Tetrahydro-pyran-2-oxy-ethanesulfinyl-propane-l-sulfinyl)-ethoxy]- tetrahydro-pyran; Ic-2 4-[2-(3-2-{2-oxyoxetan-4-yl}-ethanesulfinyl-propane-l-sulfinyl)-ethyl]-oxetan-2- one; Ic-3 3-[2-(3-2-{2-oxyoxetan-3-yl}-ethanesulfinyl-propane-l-sulfϊnyl)-ethyl]-oxetan-2- one; Ic-4 5-[2-(3-2-{2-oxo-dihydro-furan-5-yl}-ethanesulfmyl-propane-l-sulfinyl)- ethyl]-dihydro-furan-2-one; Ic-5 4-[2-(3-2- {2-oxo-dihydro-furan-4-yl} -ethanesulfinyl-propane- 1 -sulfinyl)-ethyl]- dihydro-furan-2-one; Ic-6 3-[2-(3-2-{2-oxo-dihydro-furan-3-yl}-ethanesulfinyl-propane-l-sulfinyl)-ethyl]- dihydro-furan-2-one; Ic-7 [2-(2-{3-[2-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)- ethanesulfinyl] -propane- 1 -sulfinyl} -ethyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl] -acetic acid; Ic-8 6-[2-(3-2-{2-oxo-tetrahydro-pyran-6-yl}-Ethanesulfinyl-propane-l-sulfinyl)-ethyl] -tetrahydro-pyran-2-one; Ic-9 5-[2-(3-2-{2-oxo-tetrahydro-pyran-5-yl}-Ethanesulfinyl-propane-l-sulfinyl)-ethyl] -tetrahydro-pyran-2-one; Ic-10 4-[2-(3 -2- {2-oxo-tetrahydro-pyran-4-yl} -Ethanesulfinyl-propane- 1 -sulfinyl)-ethyl] -tetrahydro-pyran-2-one; Ic-11 3-[2-(3-2-{2-oxo-tetrahydro-pyran-3-yl}-Ethanesulfinyl-propane-l-sulfinyl)-ethyl] -tetrahydro-pyran-2-one; Ic-12 2-[3-(3-Tetrahydro-pyran-2-oxy-ρropanesulfinyl-propane-l-sulfinyl)-ethoxy]- tetrahydro-pyran; Ic-13 4-{3-[3-(3-{2-oxo-oxetan-4-yl}-propane-l-sulfinyl)-propane-l-sulfmyl]-propyl}- oxetan-2-one; Ic-14 3-{3-[3-(3-{2-oxo-oxetan-3-yl}-propane-l-sulfmyl)-propane-l-sulfιnyl]-propyl}- oxetan-2-one; Ic-15 5-{3-[3-(3-{2-oxo-dihydro-furan-5-yl}-propane-l- sulfinyl)-propane-l- sulfinyl]-propyl}-dihydrofuran-2-one; Ic-16 4- {3 -[3 -(3- {2-oxo-dihydro-furan-4-yl} -propane- 1 -sulfinyl)-propane- 1 - sulfinyl]-propyl}-dihydrofuran-2-one; Ic-17 3-{3-[3-(3- {2-oxo-dihydro-furan-3 -yl} -propane- 1 -sulfinyl)-propane- 1 - sulfinyl]-propyl}-dihydrofuran-2-one; Ic-18 [2-(3-{3-[3-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-propane-l- sulfinyl]-proρane-l-sulfinyl}-propyl)-4-hydroxy-6-oxo-tetrahydro-ρyran-4-yl]- acetic acid; Ic-19 6-{3-[3-(3-{2-oxo-tetrahydro-pyran-6-yl}-propane-l-sulfinyl)-propane-l-sulfinyl]- propyl} -tetrahydro-pyran-2-one; Ic-20 5-{3-[3-(3-{2-oxo-tetrahydro-pyran-5-yl}-proρane-l-sulfinyl)-propane-l-sulfinyl]- propyl} -tetrahydro-pyran-2-one; Ic-21 4-{3-[3-(3-{2-oxo-tetrahydro-pyran-4-yl}-propane-l-sulfinyl)-propane-l-sulfmyl]- propyl} -tetrahydro-pyran-2-one; Ic-22 3-{3-[3-(3-{2-oxo-tetrahydro-pyran-3-yl}-propane-l-sulfinyl)-propane-l-sulfmyl]- propyl } -tetrahydro-pyran-2-one; Ic-24 2-[2-(3-Tetrahydro-pyran-2-oxy-ethanesulfmyl-ethane-l-sulfinyl)-ethoxy]- tetrahydro-pyran; Ic-25 4-[2-(2- {2-oxo-oxetan-4-yl} -ethanesulfmyl-ethanesulfinyl)-ethyl]-oxetan-2-one; Ic-26 3-[2-(2-{2-oxo-oxetan-3-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-oxetan-2-one; Ic-27 5-[2-(2- {2-oxo-dihydro-furan-5-yl} -ethanesulfinyl-ethanesulfinyl)-ethyl]-dihydro- furan-2-one; Ic-28 4-[2-(2- {2-oxo-dihydro-ftιran-4-yl} -ethanesulfinyl-ethanesulfinyl)-ethyl]-dihydro- furan-2-one; Ic-29 3-[2-(2- {2-oxo-dihydro-furan-3-yl} -ethanesulfinyl-ethanesulfinyl)-ethyl]-dihydro- furan-2-one; Ic-30 [2-(2-{2-[2-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)- ethanesulfinyl]-ethanesulfinyl}-ethyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl]- acetic acid; Ic-31 6-[2-(3-2-{2-oxo-tetrahydro-pyran-6-yl}-ethanesulfinyl-ethane-l-sulfinyl)-ethyl]- tetrahydro-pyran-2-one; Ic-32 5-[2-(3-2-{2-oxo-tetrahydro-pyran-5-yl}-ethanesulfinyl-ethane-l-sulfinyl)-ethyl]- tetrahydro-pyran-2-one; Ic-33 4- [2-(3 -2- {2-oxo-tetrahydro-pyran-4-yl} -ethanesulfinyl-ethane- 1 -sulfinyl)-ethyl] - tetrahydro-pyran-2-one; Ic-34 3-[2-(3-2-{2-oxo-tetrahydro-pyran-3-yl}-ethanesulfinyl-ethane-l-sulfinyl)-ethyl]- tetrahydro-pyran-2-one; II-l 6-(6-Hydroxy-5,5-dimethyl-hexane-l-sulfmyl)-2,2-dimethyl-hexan-l-ol; II-2 6-(5-Carboxy-5-methyl-hexane- 1 -sulfinyl)-2,2-dimethyl-hexanoic acid; II-3 5-(5-Hydroperoxy-4,4-dimethyl-pentane-l-sulfinyl)-2,2-dimethyl-pentanoic acid; II-4 5-(5-Hydroxy-4,4-dimethyl-pentane-l-sulfinyl)-2,2-dimethyl-pentan-l-ol; II-5 5-(5-Hydroxy-4,4-dimethyl-pentane-l-sulfmyl)-2,2-dimethyl-pentanoic acid; π-6 5-(4-Carboxy-4-methyl-pentane-l-sulfmyl)-2,2-dimethyl-pentanoic acid; π-7 7-(7-Hydroxy-6,6-dimethyl-heptane- 1 -sulfinyl)-2,2-dimethyl-heptan- 1 -ol; π-8 7-(7-Hydroxy-6,6-dimethyl-heptane- 1 -sulfinyl)-2,2-dimethyl-heptanoic acid; π-9 7-(6-Carboxy-6-methyl-heptane- 1 -sulfinyl)-2,2-dimethyl-heptanoic acid; 11-10 6-(5 ,5 -Dimethyl-6-oxo-hexane- 1 -sulfinyl)-2,2-dimethyl-hexanal; 11-11 6-(5-Methoxycarbonyl-5-methyl-hexane-l-sulfinyl)-2,2-dimethyl-hexanoic acid methyl ester; 11-12 6-(5,5-Dimethyl-6-oxo-6-phenyl-hexane-l-sulfinyl)-2,2-dimethyl-l-phenyl-hexan- 1-one; 11-13 7-(5 ,5 -Dimethyl-6-oxo-7-phenyl-heptane- 1 -sulfinyl)-3 ,3 -dimethyl-1 -phenyl-heptan -2-one; 11-14 2-Methyl-6-(5-methyl-5-sulfo-hexane-l-sulfinyl)-hexane-2-sulfonic acid; 11-15 Phosphoric acid mono- [l,l-dimethyl-5-(5-methyl-5- phosphonooxy-hexane- 1 -sulfinyl)-pentyl] ester; 11-16 7-(6,6-Dimethyl-7-oxo-heptane-l-sulfinyl)-2,2-dimethyl-heptanal; 11-17 7-(6-Methoxycarbonyl-6-methyl-heptane-l-sulfinyl)-2,2-dimethyl-heptanoic acid methyl ester; II-l 8 7-(6,6-Dimethyl-7-oxo-7-phenyl-heptane- 1 -sulfinyl)-2,2-dimethyl- 1 -phenyl-heptan -1-one; 11-19 8-(6,6-Dimethyl-7-oxo-8-phenyl-octane-l-sulfinyl)-3,3-dimethyl-l-phenyl-octan-2 -one; 11-20 2-Methyl-7-(6-methyl-6-sulfo-heptane- 1 -sulfmyl)-heptane-2-sulfonic acid; 11-21 Phosphoric acid mono-[l,l-dimethyl-6- (6-methyl-6-phosphonooxy- heptane- 1 -sulfinyl)-hexyl] ester; π-22 7-(7-Hydroxy-5,5-dimethyl-heptane-l-sulfinyl)-3,3-dimethyl-heptan-l-ol; π-23 7-(7-Hydroxy-5,5-dimethyl-heptane-l-sulfϊnyl)-3,3-dimethyl-heptanoic acid; π-24 7-(6-Carboxy-5,5-dimethyl-hexane-l-sulfinyl)-3,3-dimethyl-heptanoic acid; π-25 6-(6-Hydroxy-4,4-dimethyl-hexane- 1 -sulfinyl)-3 ,3-dimethyl-hexan- 1 -ol; π-26 6-(6-Hydroxy-4,4-dimethyl-hexane- 1 -sulfinyl)-3 ,3 -dimethyl-hexanoic acid; 11-27 6-(5-Carboxy-4,4-dimethyl-pentane-l-sulfinyl)-3,3-dimethyl-hexanoic acid; π-28 1-28 8-(8-Hydroxy-6,6-dimethyl-octane-l-sulfmyl)-3,3-dimethyl-octan-l-ol; π-29 8-(8-Hydroxy-6,6-dimethyl-octane-l-sulfinyl)-3,3-dimethyl-octanoic acid; π-30 8-(7-Carboxy-6,6-dimethyl-heptane-l-sulfinyl)-3,3-dimethyl-octanoic acid; π-31 8-(8-Hydroxy-5,5-dimethyl-octane-l-sulfinyl)-4,4-dimethyl-octan-l-ol; π-32 8-(8-Hydroxy-5 ,5 -dimethyl-octane- 1 -sulfinyl)-4,4-dimethyl-octanoic acid; 11-33 8-(7-Carboxy-5,5-dimethyl-heptane- 1 -sulfinyl)-4,4-dimethyl-octanoic acid; π-34 7-(7-Hydroxy-4,4-dimethyl-heptane- 1 -sulfinyl)-4,4-dimethyl-heptan- 1 -ol; 11-35 7-(7-Hydroxy-4,4-dimethyl-heptane- 1 -sulfinyl)-4,4-dimethyl-heptanoic acid; π-36 7-(6-Carboxy-4,4-dimethyl-hexane- 1 -sulfinyl)-4,4-dimethyl-heptanoic acid; π-37 9-(9-Hydroxy-6, 6-dimethyl-nonane- 1 -sulfinyl)-4,4-dimethyl-nonan- 1 -ol; 11-38 9-(9-Hydroxy-6,6-dimethyl-nonane- 1 -sulfinyl)-4,4-dimethyl-nonanoic acid; π-39 9-(8-Carboxy-6,6-dimethyl-octane-l-sulfinyl)-4,4-dimethyl-nonanoic acid; 11-40 5-[l,l-Dimethyl-4-(4-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl}-4- ethyl-pentane-l-sulfinyl)-butyl]-3,3a-dihydro-2H-thieno[3,2-c]ρyridine-4,6-dione; 11-41 5-[l,l-Dimethyl-4-(4-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-4- methyl-pentane-l-sulfinyl)-butyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6- dithione; 11-42 5-(4-Cyanocarbamoyl-4-methyl-pentane- 1 -sulfinyl)-2,2-dimethyl-pentanoic acid 5 cyanimide; 11-43 Phosphoramidic acid mono- {4-[4-(amino-hydroxy-phosphoryloxy)- 4-methyl- entane- 1 -sulfinyl] -1,1 -dimethyl-butyl} ester; 11-44 4-(Amino-hydroxy-phosphoryloxy)-4-methyl-l-(4-[amino-hydroxy-phosphoryloxy ]-4-methyl-pentane-l-sulfinyl)-pentane; 10 11-45 5-[ 1 , 1 -Dimethyl-5-(5- {3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl} -5- methyl-hexane- 1 -sulfinyl)-pentyl] -3 ,3 a-dihydro-2H-thieno [3 ,2-c]pyridine-4, 6- dione; 11-46 5-[l,l-Dimethyl-5-(5-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-5- methyl-hexane- 1 -sulfinyl)-pentyl] -3,3 a-dihydro-2H-thieno [3 ,2-c]pyridine-4,6- dithione; 15 11-47 6-(5-Cyanocarbamoyl-5-methyl-hexylsulfanyl)-2,2-dimethyl-hexanoic acid cyanimide; 11-48 Phosphoramidic acid mono- {5-[5-(amino-hydroxy-phosphoryloxy)- 5 -methyl-hexane- 1 -sulfinyl] -1,1 -dimethyl-pentyl} ester; 20 11-49 5-(Amino-hydroxy-phosphoryloxy)-5-methyl-l-([5-amino-hydroxy-phosphoryloxy ]-5-methyl-hexane- 1 -sulfinyl)-hexane; 11-50 1 -[ 1 , 1 -Dimethyl-5-(5-methyl-5-tetrazol- 1 -yl-hexane- 1 -sulfinyl)-pentyl]- 1 H-tetrazole; 11-51 5-[ 1 , 1 -Dimethyl-5-(5-methyl-5-tetrazol-5-yl-hexane- 1 -sulfinyl)- p entyl] - 1 H-tetrazole; 25 11-52 5-[l,l-Dimethyl-5-(5-{isoxazol-3-5-yl}-5-methyl-hexane-l-sulfinyl)-pentyl]- isoxazol-3-ol; 11-53 4-[l,l-Dimethyl-5-(5-{isoxazol-3-4-yl}-5-methyl-hexane-l-sulfinyl)-pentyl]- isoxazol-3-ol; 3 o 11-54 4-[ 1 , 1 -Dimethyl-5-(5- {2-oxo-oxetan-4-yl} -5-methyl-hexane- 1 -sulfinyl)-pentyl]-ox etan-2-one; 11-55 3-[ 1 , 1 -Dimethyl-5-(5- {2-oxo-oxetan-3-yl} -5-methyl-hexane- l-sulfinyl)-pentyl]-ox etan-2-one; 11-56 5-[l,l-Dimethyl-5-(5-(2-oxo-dihydro-furan-5-yl}-5-methyl-hexane-l-sulfinyl)- pentyl] -dihydro-furan-2-one; 35 11-57 3 -[ 1 , 1 -Dimethyl-5 -(5 -(2-oxo-dihydro-furan-3 -yl} -5 -methyl-hexane- 1 -sulfinyl)- pentyl]-dihydro-furan-2-one; 11-58 4-[ 1 , 1 -Dimethyl-5-(5-(2-oxo-dihydro-furan-4-yl} -5-methyl-hexane- 1 -sulfinyl)- pentyl] -dihydro-furan-2-one; 11-59 2-[ 1 , 1 -Dimethyl-5- {tetrahydro-pyran-2-oxy} -5 -methyl-hexane- 1 -sulfinyl)- pentyloxy] -tetrahydro-pyran; 11-60 (2-{5-[5-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-5-methyl-hex ane- 1 -sulfinyl]- 1 , 1 -dimethyl-pentyl} -4-hydroxy-6-oxo-tetrahydro-pyran-4-yl)- acetic acid; Ha-1 7-(7-Hydroxy-6-methyl-6-phenyl-heptane- 1 -sulfinyl)-2-methyl-2-phenyl-heptan- 1 - ol; IIa-2 7-(7-Hydroxy-6-methyl-6-phenyl-heptane- 1 -sulfinyl)-2-methyl-2-phenyl-heptanoιc acid; IIa-3 7-(6-Carboxy-6-ρhenyl-heptane- 1 -sulfinyl)-2-methyl-2-phenyl-heptanoic acid; IIa-4 6-(6-Hydroxy-5-methyl-5 -phenyl-hexane- 1 -sulfinyl)-2-methyl-2-phenyl-hexan- 1 -o IIa-5 6-(6-Hydroxy-5-methyl-5-phenyl-hexane-l-sulfinyl)-2-methyl-2-phenyl-hexanoic acid; IIa-6 6-(5-Carboxy-5-phenyl-hexane- 1 -sulfinyl)-2-methyl-2-phenyl-hexanoic acid; IIa-7 5-(5-Hydroxy-4-methyl-4-phenyl-pentane-l-sulfinyl)-2-methyl-2-phenyl-pentan-l- ol; IIa-8 5-(5-Hydroxy-4-methyl-4-phenyl-pentane-l-sulfinyl)-2-methyl-2-phenyl-pentanoic acid; IIa-9 5-(4-Carboxy-4-phenyl-pentane- 1 -sulfinyl)-2-methyl-2-phenyl-pentanoic acid; IIa-10 2-Methyl-7-(6-methyl-7-oxo-6-phenyl-heptane- 1 -sulfinyl)-2-phenyl-heptanal; IIa-11 7-(6-Methoxycarbonyl-6-phenyl-heptane- 1 -sulfinyl)-2-methyl-2-phenyl-heptanoic acid methyl ester; IIa-12 2-Methyl-7-(6-methyl-7-oxo-6,7-diphenyl-heptane-l -sulfinyl)- 1,2-diphenyl-heptan -1-one; IIa-13 3-Methyl-8-(6-methyl-7-oxo-6,8-diphenyl-octane-l-sulfmyl)-l,3-diρhenyl-octan-2 -one; IIa-14 2-Phenyl-7-(6-phenyl-6-sulfo-heptane-l-sulfinyl)-heptane-2-sulfonic acid; IIa-15 Phosphoric acid mono- [1 -methyl-1- phenyl-6-(6-ρhenyl-6- phosphonooxy- heptane-l-sulfinyl)-hexyl] ester; IIa-16 8-(8-Hydroxy-6-methyl-6-phenyl-octane-l-sulfinyl)-3-methyl-3-phenyl-octan-l-ol; IIa-17 8-(8-Hydroxy-6-methyl-6-phenyl-octane-l-sulfinyl)-3-methyl-3-phenyl-octanoic acid; IIa-18 8-(7-Carboxy-6-methyl-6-phenyl-heptane-l-sulfinyl)-3-methyl-3-phenyl-octanoic acid; IIa-19 7-(7-Hydroxy-5-methyl-5-phenyl-heptane-l-sulfinyl)-3-methyl-3-phenyl-heptan-l- ol; IIa-20 7-(7-Hydroxy-5-methyl-5-phenyl-heptane-l-sulfinyl)-3-methyl-3-phenyl-heptanoic acid; IIa-21 7-(6-Carboxy-5-methyl-5-phenyl-hexane-l-sulfinyl)-3-methyl-3-phenyl-heptanoic acid; o IIa-22 6-(6-Hydroxy-4-methyl-4-phenyl-hexane- l-sulfinyl)-3-methyl-3-ρhenyl-hexan- 1 -o IIa-23 6-(6-Hydroxy-4-methyl-4-phenyl-hexane- 1 -sulfinyl)-3 -methyl-3 -phenyl-hexanoic acid; IIa-24 6-(5-Carboxy-4-methyl-4-phenyl-pentane-l-sulfinyl)-3-methyl-3-phenyl-hexanoic acid; 5 IIa-25 6-(6-Hydroxy-4-methyl-4-phenyl-hexane- 1 -sulfinyl)-3 -methyl-3 -phenyl-hexanoic acid; IIa-26 6-(5-Carboxy-4-methyl-4-phenyl-pentane-l-sulfmyl)-3-methyl-3-phenyl-hexanoic acid; 0 IIa-27 9-(9-Hydroxy-6-methyl-6-phenyl-nonane- 1 -sulfinyl)-4-methyl-4-phenyl-nonan- 1 - ol; IIa-28 9-(9-Hydroxy-6-methyl-6-phenyl-nonane- 1 -sulfinyl)-4-methyl-4-phenyl-nonanoic acid; IIa-29 9-(8-Carboxy-6-methyl-6-phenyl-octane- 1 -sulfmyl)-4-methyl-4-phenyl-nonanoic acid; 5 IIa-30 8-(8-Hydroxy-5-methyl-5-phenyl-octane-l-sulfinyl)-4-methyl-4-phenyl-octan-l-ol; IIa-31 8-(8-Hydroxy-5-methyl-5-phenyl-octane- 1 -sulfinyl)-4-methyl-4-ρhenyl-octanoic acid; IIa-32 8-(7-Carboxy-5-methyl-5-phenyl-heptane-l-sulfinyl)-4-methyl-4-phenyl-octanoic 0 acid; IIa-33 7-(7-Hydroxy-4-methyl-4-phenyl-heptane-l-sulfmyl)-4-methyl-4-phenyl-heptan-l- ol; IIa-34 7-(7-Hydroxy-4-methyl-4-phenyl-heptane-l-sulfmyl)-4-methyl-4-phenyl-heptanoic acid; 5 IIa-35 7-(6-Carboxy-4-methyl-4-phenyl-hexane-l-sulfinyl)-4-methyl-4-phenyl-heptanoic acid; IIa-36 5-[l-Methyl-l-phenyl-5-(5-ρhenyl-5-{3,3a-dihydro-4,6-dioxo-2H-thieno [3,2-c]pyridin-5-yl}-hexane-l-sulfinyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c] pyridine-4,6-dione; IIa-37 5-[l-Methyl-l-phenyl-5-(5-ρhenyl-5-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c] pyridin-5 -yl} -hexane- 1 -sulfinyl)-pentyi] -3,3 a-dihydro-2H-thieno [3 ,2-c]pyridine-4, 6-dithione; IIa-38 6-(5-Cyanocarbamoyl-5-ρhenyl-hexane-l-sulfinyl)-2-methyl-2-phenyl-hexanoic acid cyanimide; IIa-39 Phosphoramidic acid mono- {5-[5- (amino- hydroxy-phosphoryloxy)-5-phenyl- hexane- 1 -sulfinyl] - 1 -methyl- 1 -phenyl-pentyl} ester; IIa-40 l-(5-[Amino-hydroxy-phosphoryloxy]-5-phenyl-hexane-l-sulfinyl)-5-[amino-hydr o oxy-phosphoryloxy]-5-phenyhexane; IIa-41 l-[l-Methyl-l-phenyl-5-(5-phenyl-5-{tetrazol-l-yl}-hexane-l-sulfinyl)-pentyl]-lH -tetrazole; IIa-42 5-[l-Methyl-l-phenyl-5-(5-phenyl-5-{tetrazol-5-yl}-hexane-l-sulfinyl)-pentyl]-lH -tetrazole; IIa-43 5-[ 1 -Methyl- 1 -phenyl-5-(5- {3-hydroxy-isoxazol-5-yl} -5-phenyl-hexane- 1 -sulfinyl) -pentyl] -isoxazol-3 -ol; IIa-44 4-[ 1-Methyl- 1 -ρhenyl-5-(5- {3-hydroxy-isoxazol-4-yl} -5-phenyl-hexane- 1 -sulfinyl) -pentyl]-isoxazol-3-ol; IIa-45 2-[ 1 -Methyl- 1 -ρhenyl-5-(5- {2-hydroxy-tetrahydro-pyranoxy} -5-phenyl-hexane- 1 - 0 sulfinyl)-pentyloxy]-tetrahydro-pyran; IIa-46 5-[ 1 -Methyl-l-phenyl-5-(5- {2-oxo-dihydro-furan-5-yl} -5-phenyl-hexane-l - sulfinyl)-pentyl]-dihydro-furan-2-one; IIa-47 4-[ 1 -Methyl- 1 -phenyl-5-(5- {2-oxo-oxetan-4-yl} -5-phenyl-hexane- 1 -sulfinyl)- pentyl] -oxetan-2-one; Ha-48 4-[ 1 -Methyl- 1 -phenyl-5-(5- {2-oxo-dihydro-nxran-4-yl} -5-phenyl-hexane- 1 - sulfinyl)-pentyl]-dihydro-furan-2-one; IIa-49 3-[ 1 -Methyl-1 -phenyl-5-(5- {2-oxo-dihydro-furan-3-yl} -5-phenyl-hexane- 1- sulfmyl)-pentyl]-dihydro-furan-2-one; IIa-50 (2-{5-[5-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-ρyran-2-yl)-5-phenyl-hex o ane- 1 -sulfinyl] - 1 -methyl- 1 -phenyl-pentyl} -4-hydroxy-6-oxo-tetrahydro-pyran-4-yl) -acetic ; III-l -(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2- yl]-propyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol; III-2 5-(6- {3 -[6-(5-Ηydroxy-4,4-dimethyl-pentyl)- 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran- 2-yl] -propyl} - 1 ,4-dioxo-l ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic 5 acid; III-3 5-(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl] -propyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-4 5-(6-{3-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-t hiopyran-2-yl]-propyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-di methyl-pentan- 1 -ol; III-5 5-(6-{3-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-t 5 hiopyran-2-yl] -propyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-di methyl-pentanoic acid; III-6 5-(6- {3-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-l -oxo-1 ,4-dihydro-4H-thiop yran-2-yl] -propyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimeth yl-pentanoic acid; 1 o III-7 6-(6- {3-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-4-oxo-4Η-thiopyran-2-yl]-propyl} -4- oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol; III-8 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thioρyran-2 -yl] -propyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-9 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thioρyran-2-yl]- 15 propyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; 111-10 6-(6-{3-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]- propyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-l-ol; III-ll 6-(6-{3-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-th iopyran-2-yl]-propyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dim 2o ethyl-hexan-1-ol; 111-12 6-(6- {3-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiop yran-2-yl]-propyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dimeth yl-hexanoic acid; 111-13 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- vinyl} - 1 -oxo-hexahycfro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol; 25 111-14 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- vinyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; IΗ-15 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]-viny 1} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; 30 111-16 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-4H-thiopyran-2-yl]-vinyl}-l ,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol; iπ-17 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2 -yl]-vinyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-18 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]- vinyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; 35 III-19 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-th iopyran-2-yl] -vinyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dime thyl-hexan-1-ol; 111-20 6-(6- {2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-th iopyran-2-yl]-vinyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dime thyl-hexanoic acid; 111-21 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiop yran-2-yl]-vinyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethy 1-hexanoic acid; III-22 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiop yran-2-yl]-vinyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethy 1-hexanoic acid; 111-23 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-hexahydro-4H-thιopyran-2-yl]- vinyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; 111-24 5-(6- {2-[6-(4-Carboxy-4-methyl-pentyl)-l -oxo-hexalιydro-4H-thiopyran-2-yl]-vin yl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; 111-25 5-(6- {2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)- 1 ,4-dioxo-4H-thiopyran-2-yl]-vinyl} - 1 ,4-dioxo-4H-thιopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol; 111-26 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran- 2-yl]-vinyl}-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-ρentanoic acid; 111-27 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl] -vinyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-28 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-t hioρyran-2-yl] -vinyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dim ethyl-pentan- 1 -ol; 111-29 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-t hiopyran-2-yl] -vinyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dim ethyl-pentanoic acid; III-30 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiop yran-2-yl] -vinyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethy 1-pentanoic acid; 111-31 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-4H-thiopyran-2-yl]-ethyl}- l,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-l-ol; 111-32 6-(6- {2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)- 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran- 2-yl]-ethyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thιopyran-2-yl)-2,2-dimethyl-hexanoic acid; 111-33 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l,4-dioxo-l,4-dihydro-4H-thiopyran-2-yl]- ethyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; 111-34 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H- thiopyran-2-yl] -ethy 1} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran- 2-yl)-2,2-dimethyl-hexan- 1 -ol; 111-35 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H- thiopyran-2-yι] -ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-hexanoic acid; 111-36 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H- 5 thiopyran-2-yl]-ethyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-hexanoic acid; 111-37 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-l,4-dioxo-4H-thiopyran-2-yl]-ethyl}- 1 ,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol; 111-38 5-(6- {2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)- 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran- 1 o 2-yl]-ethyl} - 1 ,4-dioxo-l ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; 111-39 5-(6- {2-[6-(4-Carboxy-4-methyl-pentyl)-l ,4-dioxo-l ,4-dihydro-4H-thiopyran-2- yl]-ethyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; 111-40 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-ρentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-114- thiopyran-2-yl]-ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2- 15 dimethyl-pentan-1-ol; III-41 5-(6- {2- [6-(5-Ηydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro- 114- thiopyran-2-yl]-ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-pentanoic acid; 111-42 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-114- 2 thiopyran-2-yl]-ethyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-pentanoic acid; 111-43 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- phenyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol; 111-44 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- phenyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; 25 111-45 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l-oxo-hexahydro-4H-tlιiopyran-2-yl]- phenyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; 111-46 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l,4-dioxo-4H-thiopyran-2-yl]-phenyl} -1 ,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-l -ol; 30 111-47 6-(6- {2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l ,4-dioxo-l ,4-dihydro-4H-thiopyran- 2-yl]-phenyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; 111-48 6-(6- {2-[6-(5-Carboxy-5-methyl-hexyl)- 1 ,4-dioxo- 1 ,4-dihydro-4H-thioρyran-2-yl]- phenyl} - 1 ,4-dioxo-l ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; 111-49 6-(6-{2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H- 3 thiopyran-2-yl]-phenyl}-4,4-dimethyl-l-oxo-l,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-hexan- 1 -ol; 111-50 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H- thiopyran-2-yl] -phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-hexanoic acid; 111-51 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H- thiopyran-2-yl] -phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-hexanoic acid; 111-52 5-(6- {2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- phenyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol; 111-53 5-(6- {2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)- 1 -oxo-hexahydro-4H-thiopyran-2-yl]- phenyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; 111-54 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- phenyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; 111-55 5-(6- {2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-l ,4-dioxo-4H-thiopyran-2-yl]- phenyl} - 1 -oxo- 1 ,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-ρentan- 1 -ol; 111-56 5-(6- {2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)- 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran- 2-yl]-phenyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; 111-57 5-(6- {2-[6-(4-Carboxy-4-methyl-pentyl)- 1 ,4-dioxo- 1 ,4-dihydro-4H-thioρyran-2- yl]-phenyl} - 1 ,4-dioxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; 111-58 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-ρentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H- thiopyran-2-yl]-phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-pentan-1-ol; 111-59 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-ρentyl)-4,4-dimethyl-l-oxo-l,4-dihydro-4H- thiopyran-2-yl]-phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiopyran-2-yl)-2,2- dimethyl-pentanoic acid; III-60 5-(6- {2-[6-(4-Carboxy-4-methyl-ρentyl)-4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H- thiopyran-2-yl] -phenyl} -4,4-dimethyl- 1 -oxo- 1 ,4-dihydro-4H-thiop ran-2-yl)-2,2- dimethyl-pentanoic acid; 111-61 5-(5- {3-[5-(5-Ηydroxy-4,4-dimethyl-pentyl)- 1-oxo- lH-4H-thiophen-2-yl] -propyl} - 1 -oxo- lΗ-4H-thιophen-2-yl)-2,2-dimethyl-pentan- 1 -ol; 111-62 5-(5 - {3 -[5-(5 -Ηydroxy-4,4-dimethyl-ρentyl)- 1 -oxo- lH-4H-thiophen-2-yl]-ρroρyl} - 1 -oxo- lΗ-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; III-63 5-(5-{3-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-lΗ-4H-thiophen-2-yl]-propyl}-l- oxo-lΗ-4H-tlιiophen-2-yl)-2,2-dimethyl-pentanoic acid; 111-64 6-(5-{3-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-lΗ-4H-thiophen-2-yl]-propyl}- 1 -oxo- 1 Η-4H-tMophen-2-yl)-2,2-dimethyl-hexan- 1 -ol; III-65 6-(5-{3-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-lΗ-4H-thiophen-2-yl]-propyl}- l-oxo-lΗ-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; 111-66 6-(5-{3-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-lH-4H-thiophen-2-yl]-propyl}-l- oxo- lΗ-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; 111-67 6-(5-{2-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- vinyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexan- 1 -ol; III-68 6-(5- {2-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l -oxo-tetrahydro-4H-thiophen-2-yl]- vinyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; 111-69 6-(5-{2-[5-(6-Ηydroperoxy-5,5-dimethyl-hexyl)-l-oxo-tetrahydro-4H-thiophen-2- yl]-vinyl}-l-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; 111-70 6-(5-{2-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-lΗ-4H-thioρhen-2-yl]-vinyl}-l -oxo-lΗ-4H-thiophen-2-yl)-2,2-dimethyl-hexan-l-ol; 10 111-71 6-(5-{2-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-lΗ-4H-thiophen-2-yl]-vinyl}-l -oxo- lΗ-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; 111-72 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-lΗ-4H-thiophen-2-yl]-vinyl}-l-oxo - lΗ-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; 111-73 5-(5-{2-[5-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- vinyl}-l-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentan-l-ol; 15 111-74 5-(5-{2-[5-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- vinyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; 111-75 5-(5- {2-[5-(4-Carboxy-4-methyl-pentyl)-l -oxo-tetrahydro-4H-thiophen-2-yl]- vinyl} - 1 -oxo-tetrahydrO-4H-thioρhen-2-yl)-2,2-dimethyl-pentanoic acid; 20 ΪII-76 5-(5-{2-[5-(5-Ηydroxy-4,4-dimethyl-ρentyl)-l-oxo-lΗ-4H-thiophen-2-yl]-vinyl}- 1 -oxo- 1 Η-4H-thioρhen-2-yl)-2,2-dimethyl-pentan- 1 -ol; iπ-77 5-(5-{2-[5-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-lΗ-4H-thiophen-2-yl]-vinyl}- 1 -oxo- 1 Η-4H-tώophen-2-yl)-2,2-dimethyl-pentanoic acid; 111-78 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-lΗ-4H-thiophen-2-yl]-vinyl}-l- oxo-lΗ-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; 25 111-79 6-(5-{2-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-tetrahydro-4H-thioρhen-2-yl]- vinyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexan- 1 -ol; 111-80 6-(5-{2-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- vinyl} - 1 -oxo-tetrahyd o-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; 30 111-81 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-tetrahydro-4H-thioρhen-2-yl]- vinyl} - 1 -oxo-tetrahydro-4H-thioρhen-2-yl)-2,2-dimethyl-hexanoic acid; 111-82 6-(5-{2-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-lΗ-4H-thiophen-2-yl]-vinyl}-l -oxo-lΗ-4H-thiophen-2-yl)-2,2-dimethyl-hexan-l-ol; 111-83 6-(5- {2-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)- 1-oxo- lH-4H-thiophen-2-yl]-vinyl} - 1 -oxo-lΗ-4H-thioρhen-2-yl)-2,2-dimethyl-hexanoic acid; 35 111-84 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-lH-4H-thioρhen-2-yl]-vinyl}-l-oxo - lΗ-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; 111-85 5-(5-{2-[5-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-lΗ-4H-thiophen-2-yl]-ethyl}- 1 -oxo- lΗ-4H-thiophen-2-yl)-2,2-dimethyl-ρentan- 1 -ol; 111-86 5-(5-{2-[5-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-lΗ-4H-thiophen-2-yl]-ethyl}- l-oxo-lΗ-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; 111-87 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-lΗ-4H-thiophen-2-yl]-ethyl}-l- oxo- 1 Η-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-1 5-(6-{3-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-propyl}- tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol; IIIa-2 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-ρropyl}- tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-3 5-(6- {3-[6-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiopyran-2-yl]-propyl} - tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-4 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl}- tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexan-l-ol; IIIa-5 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl}- tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-6 6-(6- {3-[6-(5-Carboxy-5-methyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl} - tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-7 6-(6- {2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- ethyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan- 1 -ol; IIIa-8 6-(6- {2-[6-(6-Ηydroxy-5,5-dimethyl-hexyl)-l -oxo-hexahydro-4H-thiopyran-2-yl]- ethyl}-l-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid IIIa-9 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- ethyl} -1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-10 5-(6-{2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- ethyl} - 1 -oxo-hexahydiO-4H-thiopyran-2-yl)-2,2-dimethyl-pentan- 1 -ol; IIIa-11 5-(6- {2-[6-(5-Ηydroxy-4,4-dimethyl-pentyl)- 1 -oxo-hexahydro-4H-thiopyran-2-yl]- ethyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-12 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-l-oxo-hexahydro-4H-thiopyran-2-yl]- ethyl} - 1 -oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-13 5-(5-{3-[5-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- propyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentan- 1 -ol; IIIa-14 5-(5-{3-[5-(5-Ηydroxy-4,4-dimethyl-ρentyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- propyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-15 5-(5-{3-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-tefrahydro-4H-thiophen-2-yl]- propyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-16 6-(5-{3-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- propyl} - 1 -oxo-tefrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexan- 1 -ol; IIIa-17 6-(5-{3-[5-(6-Ηydroxy-5,5-dimethyl-hexyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- propyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid IIIa-18 6-(5-{3-[5-(5-Carboxy-5-methyl-hexyl)-l-oxo-tetralιydro-4H-thiophen-2-yl]- propyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-19 5-(5-{2-[5-(5-Ηydroxy-4,4-dimethyl-pentyl)-l-oxo-tetrahydro-4H-thiophen-2-yl]- ethyl}-l-oxo-tetrahyd o-4H-thiophen-2-yl)-2,2-dimethyl-pentan-l-ol; IIIa-20 5-(5- {2- [5-(5-Ηydroxy-4,4-dimethyl-pentyl)- 1 -oxo-tetrahydro-4H-thioρhen-2-yl]- ethyl} -l-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; or IIIa-21 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-l-oxo-tetralιydro-4H-thiophen-2-yl]- ethyl} - 1 -oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof. 36. A pharmaceutical composition comprising a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35 and a pharmaceutically acceptable vehicle, excipient, or diluent. 37. A pharmaceutical composition comprising the following compound: 6-(5,5-Dimethyl-6-hydroxy-hexane-l-sulfinyl)-2,2-dimethyl-hexan-l-ol or pharmaceutically acceptable salt, hydrate, solvate, clathrate, enantiomer, diastereomer, racemate, or mixture thereof and a pharmaceutically acceptable vehicle, excipient, or diluent. 38. A method for treating or preventing a cardiovascular disease in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 39. A method for treating or preventing a dyslipidemia in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 40. A method for treating or preventing a dyslipoproteinemia in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 41. A method for treating or preventing a disorder of glucose metabolism in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 42. A method for treating or preventing Alzheimer's Disease in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 43. A method for treating or preventing Syndrome X or Metabolic Syndrome in a patient, comprising administering to a patient in need of such treatment or prevention a Q therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 44. A method for treating or preventing septicemia in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 5 45. A method for treating or preventing a thrombotic disorder in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 0 46. A method for treating or preventing a peroxisome proliferator activated receptor associated disorder in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 5 47. A method for treating or preventing obesity in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 48. A method for treating or preventing pancreatitis in a patient, comprising Q administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 49. A method for treating or preventing hypertension in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective 5 amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 50. A method for treating or preventing renal disease in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 51. A method for treating or preventing cancer in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 52. A method for treating or preventing inflammation in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective Q amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 53. A method for treating or preventing impotence in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 5 54. A method for reducing the fat content of meat in livestock comprising administering to livestock in need of such reduction a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35. 0 55. A method for reducing the cholesterol content of fowl eggs comprising administering to a fowl a therapeutically effective amount of a compound of claim 1 , 9, 15, 18, 20, 21, 26, 31 or 35. 5 0 5

Inventors: DASSEUX JEAN-LOUIS H, ONICIU CARMEN DANIELA, DASSEUX, JEAN-LOUIS, H., ONICIU, CARMEN, DANIELA
Applicants: ESPERION THERAPEUTICS INC, ESPERION THERAPEUTICS, INC.
Application year: 2001
Main classification: C07C317
IPC codes: A61K31, A61P1, A61P3, A61P7, A61P9, A61P13, A61P15, A61P25, A61P29, A61P31, A61P35, C07C317, C07C323, C07F9