SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS

Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula (I) wherein one of X, Y or Z is independently -S-,-0- CH2- or >N-R<6>, the others are -CH2-; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; R<4> is (C1-6)-alkyl; R<5> is independently in each occurrence (C1-6)-alkyl, (C1-6)-alkenyl, (C1-6)- alkynyl or cycloalkyl; and R<1>, R<2>, and R<3> are hydrogen or specified substituents. These compounds are useful for treating diseases associated with smooth muscle disorders.

Description: SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS This invention relates to compounds comprising the general formula I wherein R 1 , R 2 and R 3 are independently in each occurrence hydrogen, halogen, (C 1-6 )-alkyl 5 -OR', -SR\ -NR'R", -SOR, -SO 2 R', -COOR', -OCOR', -OCONR'R", -OSO 2 R', -OSO 2 NR'R"; -NR'SO 2 R", -NR'COR", -SO 2 NR'R", -SO 2 (CH 2 )ι -3 CONR'R" 5 -CONR'R", cyano, halogenalkyl or nitro; or R 1 and R 2 if adjacent, taken together with the carbons to which they are attached may also form a 5- to 7- membered aromatic, saturated or unsaturated ring, optionally incorporating one or two ring heteroatoms chosen from N, S(O) 0-2 , or O, and optionally substituted with (Cι- 6 )-alkyl, halogen, cyano or lower alkoxy; R' and R" are independently in each occurrence hydrogen, ( ^-alkyl, substituted (C 1-6 )-alkyl, (Co^-alkyl- alkoxy, aryl, heterocyclyl, heteroaryl, aryl-(C 1-3 )-alkyl, heteroaryl-(C 1-3 )-alkyl, heterocyclyl- (Cι -3 )-alkyl, cycloalkyialkyl, cycloalkyl, or R' and R" together with the nitrogen they are attached may also form a 5- to 7- membered ring, optionally incorporating one additional ring heteroatom chosen from N, O or S(O) 0-2 ; R 4 is independently in each occurrence (Ci. 6 )-alkyl; R 5 is independently in each occurrence ( ^-alkyl, (C 1-6 )-alkenyl, (Cι -6 )-alkynyl or cycloalkyl; one of X, Y or Z is independently -S-, -O-, -CH 2 - or >N-R 6 , the others are -CH 2 -; R 6 is hydrogen, halogenalkyl, aryl-(C 1-6 )-alkyl > heteroaryl-(C 1-6 )-alkyl, -(Cι -6 )-CR'R'R', -COOR', -SO 2 R, -C(O)R', -SO 2 -(CH 2 )o-3-NR'R" 5 -CONR'R", -C(O)OCH 2 OC(O)R' > -C(O)O-CH 2 -S-C(O)R or -PO(OR') 2 , wherein R and R" are as defined above; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; or prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. It has been surprisingly found that compounds of formula I are M2/M3 selective muscarinic receptor antagonists. Acetylcholine (Ach) is the principal transmitter of the parasympathetic nervous system. The physiological actions of Ach are mediated by activation of either nicotinic or muscarinic receptors. Both of these receptor classes are heterogeneous: e.g., the muscarinic receptor family comprises five subtypes (Mi, M 2 , M 3 , M 4 , and M 5 ) each encoded by distinct genes and possessing unique pharmacology and distribution. Almost all smooth muscle tissues express both muscarinic M2 and M3 receptors, both of which have a functional role. M2 receptors outnumber M3 receptors by a proportion of approximately 4 to 1. Generally, M3 receptors mediate the direct contractile effects of acetylcholine in the vast majority of smooth muscle tissues. M2 receptors, on the other hand, cause smooth muscle contraction indirectly by inhibiting sympathetically (β- adrenoreceptor)-mediated relaxation. Compounds that act as antagonists of muscarinic receptors have been used to treat several disease states associated with improper smooth muscle function.- Until recently, most of these compounds have been non-selective for the various muscarinic receptor subtypes, leading to unpleasant anti-cholinergic side-effects such as dry mouth, constipation, blurred vision, or tachycardia. The most common of these side-effects is dry- mouth resulting from muscarinic receptor blockade in the salivary gland. Recently developed M2 or M3 specific antagonists have been shown to have reduced side effects. Evidence suggests that concurrent blockade of M2 and M3 receptors could be therapeutically effective in the treatment of disease states associated with smooth muscle disorders. Few M2/M3 selective antagonists have been developed. The present invention fills this need by providing these types of antagonists useful in the treatment of disease states associated with improper smooth muscle function. More information about muscarinic receptor subtypes and antagonists thereof can be obtained from the following literature. Certain subtypes of the muscarinic receptor in smooth muscle are described in Ehlert et al., Life Sciences 1997, 61, 1729-1740. Hedge et al, Life Sciences 1999, 64, 419-428, refers to muscarinic receptor subtypes modulating smooth muscle contractility in the urinary bladder. Eglen et al., Trends. Pharmacol Sci. 1994., 15, 114-119, and Eglen, et al., Pharmacol. Rev. 1996, 48, 531-565, refer to certain muscarinic receptor subtypes and smooth muscle function. Clinical studies of selective muscarinic antagonists are described in Nilvebrant et al., Life Sciences 1997, 60, 1129-1136, Alabaster, Life Sciences 1997, 60, 1053-1060; Osayu et al., DrugRes. 1994, 44, 1242-1249, and Homma, et al., Neurourology and Urodynamics 1997, 345-346. Selective modulation of muscarinic receptor subtypes is reported in Eglen and Hegde, Emerging Drugs 1998, 3, 67-79. Eglen et al. Curr. Opin. Chem. Biol. 1999, 3, 426-432, refers to muscarinic receptor ligands and their therapeutic potential. A certain classification of muscarinic acetylcholine receptors is described in Caulfield et al., Pharmacological Reviews 1998, 50(2), 279-290. In the following literature compounds related to compounds of general formula I are described. US 5,693,630 assigned to Astra Aktiebolag refers to certain phenylethyl- and phenylpropylamines for the treatment of psychiatric disorders. US 5,382,595, US 5,177,089, US 5,047,417and US 5,607,953 assigned to Eisai Co., Ltd. refer to certain butenoic and propenoic acid derivatives. Certain N-(4-amino-2-butynyl)-N-alkyl- carboxamides useful as stimulants of depressants of the central nervous system are described in US 3,354,178 and US 4,065,471 assigned to Sterling Drug Inc.. US 4,087,541 and US 4,038,407 assigned to Boehringer Ingelheim GmbH refer to certain 2- (aralkylaminoalkyl)phtalimidines useful for slowing the heart rate. US 4,490,369 assigned to Dr. Karl Thomae GmbH discloses certain benzazepine derivatives and their use as brady cardiacs. US 3,054,794 assigned to US Vitamin & Pharmaceutical Co. refers to a process for preparing 3-(aminoalkyl)-oxazolidine-2,4,diones. Certain benzene derivatives for treating ischemic diseases are described in US 5,998,452 assigned to Chugai Seiyaku Kabushiki Kaisha, Benzothiazepine vasodilators having aralkyl substitution are disclosed in US 4,729,994 assigned to McNeilab Inc.. FR 2,302, 733 assigned to Dr. Karl Thomae GmbH refers to certain arylalkoylamines and EP 259,793 assigned to Dr. Karl Thomae GmbH refers to certain naphthyl derivatives. WO 9943657 assigned to F. Hoffmann-La Roche AG refers to certain 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives as muscarinic receptor antagonists. Certain l-ethyl-3-(2-dialkylaminoethyl)-hexahydro- pyrimidin-2-ones are described in Singh et al, Indian Journal of Chemistry 1976, 14, 528- 531. Glozman et al., Khim.-Farm.Zh. 1996, 30(4), 11-14, refers to certain substituted 1 - (dialkylaminoalkyl) -4-phenylpyrrolidin-2-ones. All publications, patents, and patent applications cited herein, whether supra or infra, are each hereby incorporated by reference in its entirety. Objects of the present invention are heterocyclylalkylamine derivatives of Formula I, prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing a fherapeutically effective amount of at least one compound of Formula I, or prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof, in admixture with at least one suitable carrier. In a more preferred embodiment, the pharmaceutical compositions are suitable for administration to a subject having a disease state which is alleviated by treatment with a muscarinic M2/M3 receptor antagonist. In another aspect the invention relates to the use of these compounds in the treatment of a subject having a disease state that is alleviated by treatment with a muscarinic M2/M3 receptor antagonist. In a preferred embodiment, the subject has a disease state comprising smooth muscle disorders; preferably genitourinary tract disorders, respiratory tract disorders, gastrointestinal tract disorders, more preferably genitourinary tract disorders such as overactive bladder or detrusor hyperactivity and its symptoms such as the changes symptomatically manifested as urgency, frequency, reduced bladder capacity, incontinence episodes, and the like; the changes urodynamically manifested as changes in bladder capacity, micturition threshold, unstable bladder contractions, sphincteric spasticity, and the like; and the symptoms usually manifested in detrusor hyperreflexia (neurogenic bladder), in conditions such as outlet obstruction, outlet insufficency, pelvic hypersensitivity, or in idiopathic conditions such as detrusor instability, and the like. In another preferred embodiment, the disease comprises respiratory tract disorders such as allergies and asthma. In another preferred embodiment, the disease state comprises gastrointestinal disorders. In another aspect, the invention relates to a process for preparing a compound of Formula I, which process comprises a) reacting a compound having a general formula II II with a compound of general formula III to provide a compound of general formula I wherein R ) 1 , τ R>2 , R , R , R , m, n, X, Y, and Z are as defined herein; or b) (i) reacting an aryl metal compound having a general formula IV IV in which M is a metal or a magnesium halide, with a compound of formula V V in which R is alkyl, aryl or arylalkyl, and R and R are alkyl or alkoxy, or R and R together with the nitrogen to which they are attached form a ring, to afford a compound of formula VT VI and (ii) reducing the compound of formula VI followed by cyclization, and treating with a compound of formula R 5 L, wherein L is a leaving group, to afford a compound of formula VII and (iii) reducing the compound of formula VII, and treating with a compound of general formula II II to provide a compound of general formula I wherein R , R , R , R , R , m, n, X, Y, and Z are as defined herein; or c) (i) reducing a compound of formula VI VI followed by cyclization and (ii) treating a compound of formula VI with a compound of formula VIII VIII wherein L is a leaving group, and (iii) reducing the product to afford a compound of formula IX IX and (iv) alkylating a compound of formula IX with an appropriate aldehyde or with a compound of Formula R 5 L, wherein L is a leaving group, to provide a compound of formula I wherein R ,ι , R , R , R , R , X, Y, Z, m and n are defined as described herein. Unless otherwise stated, the following terms used in this application, including the specification and claims, have the definitions given below. It must be noted that, as used in the specification and the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. "Lower alkyl" means the monovalent linear or branched saturated hydrocarbon radical, having from one to six carbon atoms inclusive, unless otherwise indicated. Examples of lower alkyl radicals include, but are not limited to, methyl, ethyl, propyl, isopropyl, 1-ethylpropyl, sec-butyl, tert-butyl, n-butyl, n-pentyl, n-hexyl, and the like. "Substituted lower alkyl" means the lower alkyl as defined herein, including one to three substituents, preferably one substituent such as hydroxyl, alkoxy, amino, amido, carboxyl, acyl, halogen, cyano, nitro, thiol. These groups may be attached to any carbon atom of the lower alkyl moiety. Examples of substituted lower alkyl radicals include, but are not limited to, 2-methoxyethyl, 2-hydroxyefhyl, dimethyl-aminocarbonylmethyl, 4- hydroxy-2,2-dimethyl-butyl, trifluoromefhyl, trifluorobutyl and the like. "Alkylene" means the divalent linear or branched saturated hydrocarbon radical, having from one to six carbons inclusive, unless otherwise indicated. Examples of alkylene radicals include, but are not limited to, methylene, ethylene, propylene, 2-mefhyl- propylene, butylene, 2-ethylbutylene, and the like. "Alkenyl" means the monovalent linear or branched unsaturated hydrocarbon radical, containing a double bond and having from two to six carbon atoms inclusive, unless otherwise indicated. Examples of alkenyl radicals include, but are not limited to, ethenyl, allyl, 1-propenyl, 2-butenyl, and the like. "Alkynyl" means the monovalent linear or branched unsaturated hydrocarbon radical, containing a triple bond and having from two to six carbon atoms inclusive, unless otherwise indicated. Examples of alkynyl radicals include, but are not limited to, ethynyl, 1-propynyl, 2-butynyl, propargyl, and the like. "Alkoxy" means the radical -O-R, wherein R is a lower alkyl radical as defined herein. Examples of alkoxy radicals include, but are not limited to, methoxy, ethoxy, isopropoxy, and the like. "Aryl" means the monovalent aromatic carbocyclic radical consisting of one individual ring, or one or more fused rings in which at least one ring is aromatic in nature, which can optionally be substituted with one or more, preferably one or two, substituents selected from hydroxy, cyano, lower alkyl, lower alkoxy, lower halogenalkoxy, alkylthio, halogen, halogenalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, lower alkylalkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, unless otherwise indicated. Alternatively two adjacent atoms of the aryl ring may be substituted with a methylenedioxy or ethylenedioxy group. Examples of aryl radicals include, but are not limited to, phenyl, naphthyl, biphenyl, indanyl, anthraquinolyl, tert-butyl-phenyl, 1,3-benzodioxolyl, and the like. "Arylalkyl" (or "aralkyl") means the radical R'R"-, wherein R' is an aryl radical as defined herein, and R" is an alkyl radical as defined herein. Examples of arylalkyl radicals include, but are not limited to, benzyl, phenylethyl, 3-phenylpropyl, and the like. "Cycloalkyl" means the monovalent saturated carbocyclic radical consisting of one or more rings, preferably one or two rings, of three to eight carbons per ring, which can optionally be substituted with one or more, preferably one or two substitutents, selected from hydroxy, cyano, lower alkyl, lower alkoxy, lower halogenalkoxy, alkylthio, halogen, halogenalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, unless otherwise indicated. Examples of cycloalkyl radicals include, but are not limited to, cyclopropyl, cyclobutyl, 3-ethylcyclobutyl, cyclopentyl, cycloheptyl, and the like. "Cycloalkylalkyl" means the radical R'R"-, wherein R' is a cycloalkyl radical as defined herein, and R" is an alkyl radical as defined herein. Examples of cycloalkylalkyl radicals include, but are not limited to, cyclopropylmethyl, cyclohexylmefhyl, cyclopentylethyl, and the like. "Heteroaryl" means the monovalent aromatic cyclic radical having one or more rings, preferably one to three rings, of four to eight atoms per ring, incorporating one or more heteroatoms, preferably one or two, within the ring (chosen from nitrogen, oxygen, or sulfur), which can optionally be substituted with one or more, preferably one or two substituents selected from hydroxy, cyano, lower alkyl, lower alkoxy, lower halogenalkoxy, alkylthio, halogen, halogenalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, unless otherwise indicated. Examples of heteroaryl radicals include, but are not limited to, imidazolyl, oxazolyl, thiazolyl, pyrazinyl, thienyl, furanyl, pyridinyl , quinolinyl, isoquinolinyl, benzofuryl, benzothiophenyl, benzothiopyranyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, benzopyranyl, indazolyl, indolyl, isoindolyl, quinolinyl, isoquinolinyl, naphthyridinyl, benezenesulfonyl-thiophenyl ,and the like. "Heteroarylalkyl" (or "heteroaralkyl") means the radical of the formula R'R", wherein R' is a heteroaryl radical as defined herein, and R" is an alkylene radical as defined herein. Examples of heteroarylalky radicals include, but are not limited to, 2-imidazolylmethyl, 3- pyrrolylethyl, and the like. "Heterocyclyl" means the monovalent saturated cyclic radical, consisting of one or more rings, preferably one to two rings, of three to eight atoms per ring, incorporating one or more ring heteroatoms (chosen from N,O or S(O) 0-2 ), and which can optionally be substituted with one or more, preferably one or two substituents selected from hydroxy, oxo, cyano, lower alkyl, lower alkoxy, lower halogenalkoxy, alkylthio, halogen, halogenalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, unless otherwise indicated. Examples of heterocyclic radicals include, but are not limited to, morpholinyl, piperazinyl, piperidinyl, pyrrolidinyl, tetrahydropyranyl, thiomorpholinyl, quinuclidinyl, and the like. "Heterocycloalkyl" ( or "heterocyclylalkyl") means the radical of the formula R'R", wherein R is a heterocyclic radical as defined herein, and R" is an alkylene radical as defined herein. Examples of heterocycloalkyl radicals include, but are not limited to, 1- piperazinylmethyl, 2-morpholinomethyl, and the like. "Halogen" means the radical fluoro, bromo, chloro, and/or iodo. "Halogenalkyl" means the lower alkyl radical as defined herein substituted in any position with one or more halogen atoms as defined herein. Examples of halogenalkyl radicals include, but are not limited to, 1,2-difluoropropyl, 1,2-dichloropropyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2,2,2-trichloroethyl, and the like. "Hydroxyalkyl" means the lower alkyl radical as defined herein, substituted with one or more hydroxy groups. Examples of hydroxyalkyl radicals include, but are not limited to, hydroxymethyl, 2-hydroxyethyl, 2-hydroxypropyl, 3-hydroxypropyl, 2-hydroxybutyl, 3- hydroxybutyl, 4-hydroxybutyl, 2,3-dihydroxypropyl, l-(hydroxymethyl)-2-hydroxyethyl, 2,3-dihydroxybutyl, 3,4-dihydroxybutyl, and 2- (hydroxymethyl) -3-hydroxypropyl, and the like. "Alkylthio" means the radical -SR, wherein R is a lower alkyl radical as defined herein. Examples of alkylthio radicals include, but are not limited to, methylthio, butylthio, and the like. "Alkylamino" means the radical -NR'R", wherein R' is a lower alkyl radical as defined herein, and R" is hydrogen or lower alkyl as defined herein. Examples of alkylamino radicals include, but are not limited to, methylamino, (1-methylpropyl) amino, dimethylamino, methylethylamino, diethylamino, hydroxyethyl-ethylamino, methoxyethyl-ethylamino and the like. "Acyloxy" means the radical -OC(O)R, wherein R is a lower alkyl radical as defined herein. Examples of acyloxy radicals include, but are not limited to, acetoxy, propionyloxy, and the like. "Alkoxycarbonyl" or "alkyl ester" means the radical -C(O)-O-R, wherein R is a lower alkyl radical as defined herein. Examples of alkoxycarbonyl radicals include, but are not limited to, methoxycarbonyl, ethoxycarbonyl, sec-butoxycarbonyl, isopropyloxy- carbonyl, and the like. "Aryloxycarbonyl" or "aryl ester" means the radical -C(O)-O-R, wherein R is an aryl radical as defined herein. Examples of aryloxycarbonyl radicals include, but are not limited to phenyl ester, naphthyl ester, and the like. "Arylalkoxycarbonyl" or "arylalkyl ester" means the radical -C(O)-O-RR', wherein R is a lower alkyl radical and R' is an aryl radical as defined herein. Examples of aryloxycarbonyl radicals include, but are not limited to benzyl ester, phenyl ethyl ester, and the like. "Alkylcarbonyl" ( or "acyl") means the radical R-C(O)-, wherein R is a lower alkyl radical as defined herein. Examples of alkylcarbonyl radicals include, but are not limited to acetyl, propionyl, n-butyryl, sec- butyryl, t- butyryl, iso-propionyl and the like. "Arylcarbonyl" means the radical R-C(O)-, wherein R is an aryl radical as defined herein. Examples of arylcarbonyl radicals include, but are not limited to, benzoyl, naphthoyl, and the like. "Arylalkylcarbonyl" (or "aralkylcarbonyl") means the radical R-C(O)-, wherein R is an aralkyl radical as defined herein. Examples of aralkylcarbonyl radicals include, but are not limited to, phenylacetyl, and the like. "Heteroarylcarbonyl" means the radical R-C(O)-, wherein R is an heteroaryl radical as defined herein. Examples of heteroarylcarbonyl radicals include, but are not limited to, pyridinoyl, 3-methylisoxazoloyl, isoxazoloyl, thienoyl, furoyl, and the like. "Heterocyclylcarbonyl" ( or "heterocyclocarbonyl") means the radical R-C(O)-, wherein R is an heterocyclyl radical as defined herein. Examples of heterocyclylcarbonyl radicals include, but are not limited to, piperazinoyl, morpholinoyl, pyrrolindinoyl, and the like. "Cycloalkylcarbonyl" means the radical R-C(O)-, wherein R is a cycloalkyl radical as defined herein. Examples of cycloalkylcarbonyl radicals include, but are not limited to, cyclobutanoyl, cyclopentanoyl, cyclohexanoyl, and the like. "Alkylaminocarbonyl" means the radical -C(O)NR'R", wherein R is lower alkyl as defined herein, and R" is hydrogen or lower alkyl as defined herein. Examples of alkylaminocarbonyl include, but are not limited to methylaminocarbonyl, dimethyl- aminocarbonyl, t-butylaminocarbonyl, n-butylaminocarbonyl, iso-propylaminocarbonyl and the like. "Arylaminocarbonyl" means the radical -C(O)NR'R", wherein R is aryl as defined herein, and R" is hydrogen or aryl as defined herein. Examples of arylaminocarbonyl include, but are not limited to phenylaminocarbonyl, methoxyphenylaminocarbonyl, diphenylaminocarbonyl, dimethoxyphenylaminocarbonyl, and the like. "Heteroarylaminocarbonyl" means the radical -C(O)NR'R", wherein R' is heteroaryl as defined herein, and R" is hydrogen or heteroaryl as defined herein. Examples of heteroarylaminocarbonyl include, but are not limited to pyridinylaminocarbonyl, thienylaminocarbonyl, furanylaminocarbonyl, and the like. "Alkylcarbonylamino" means the radical -NC(O)R', wherein R' is lower alkyl as defined herein. Examples of alkylcarbonylamino include, but are not limited to methylcarbonylamino, iso-propylcarbonylamino, t-butylcarbonylamino, and the like. "Arylcarbonylamino" means the radical -NC(O)R, wherein R' is aryl as defined herein. Examples of arylcarbonylamino include, but are not limited to phenylcarbonyl- amino, anisoylcarbonylamino, and the like. "Alkylcarbamoyl" means the radical -OC(O)NR'R", wherein R' is lower alkyl as defined herein, and R" is hydrogen or lower alkyl as defined herein. Examples of alkylcarbamoyl include, but are not limited to methylcarbamoyl, ethylcarbamoyl, and the like. "Arylcarbamoyl" means the radical -OC(O)NR'R", wherein R is aryl as defined herein, and R" is hydrogen or aryl as defined herein. Examples of arylcarbamoyl include, but are not limited to phenylcarbamoyl, naphthylcarbamoyl, and the like. "Arylalkylcarbamoyl" means the radical -OC(O)NHR'R", wherein R' is lower alkyl as defined herein, and R" is aryl as defined herein. Examples of arylalkylcarbamoyl include, but are not limited to benzylcarbamoyl, phenylethylcarbamoyl, and the like. "Alkylaminosulfonyl" means the radical -S(O) 2 NR'R", wherein R' is lower alkyl as defined herein, and R" is hydrogen or lower alkyl as defined herein. Examples of alkylaminosulfonyl include, but are not limited to methylaminosulfonyl, dimefhyl- aminosulfonyl, and the like. "Arylaminosulfonyl" means the radical -S(O) 2 NR'R", wherein R' is aryl as defined herein, and R" is hydrogen or aryl as defined herein. Examples of arylaminosulfonyl include, but are not limited to phenylaminosulfonyl, methoxyphenylaminosulfonyl, and the like. "Heteroarylaminosulfonyl" means the radical -S(O) 2 NR'R", wherein R' is heteroaryl as defined herein, and R" is hydrogen or heteroaryl as defined herein. Examples of heteroarylaminosulfonyl include, but are not limited to thienylaminosulfonyl, piperidinylaminosulfonyl, furanylaminosulfonyl, imidazolylaminosulfonyl and the like. "Alkylsulfonylamino" means the radical -NS(O) 2 R, wherein R' is lower alkyl as defined herein. Examples of alkylsulfonylamino include, but are not limited to mefhyl- sulfonylamino, propylsulfonylamino, and the like. "Arylsulfonylamino" means the radical -NS(O) 2 R', wherein R is lower alkyl as defined herein. Examples of arylsulfonylamino include, but are not limited to phenyl- sulfonylamino, naphthylsulfonylamino, and the like. "Alkylsulfonyl" means the radical -S(O) 2 R, wherein R is lower alkyl or a substituted lower alkyl as defined herein. Examples of alkylsulfonyl include, but are not limited to methylsulfonyl, trifluoromethylsulfonyl, propylsulfonyl, and the like. "Arylsulfonyl" means the radical -S(O) 2 R, wherein R is aryl as defined herein. Examples of arylsulfonyl include, but are not limited to phenylsulfonyl, toluenesulfonyl, nitrophenylsulfonyl, mefhoxyphenylsulfonyl, 3,4,5-trimethoxyphenylsulfonyl, and the like. "Heteroarylsulfonyl" means the radical -S(O) 2 R, wherein R is heteroaryl as defined herein. Examples of heteroarylsulfonyl include, but are not limited to thienylsulfonyl, furanylsulfonyl, imidazolylsulfonyl, N-methylimidazolylsulfonyl and the like. "Heterocyclylsulfonyl" means the radical -S(O) R, wherein R is heterocyclyl as defined herein. Examples of heterocyclylsulfonyl include, but are not limited to piperidinylsulfonyl, piperazinylsulfonyl, and the like. "Alkylsulfonyloxy" means the radical -O S(O) 2 R, wherein R is lower alkyl or substituted lower alkyl as defined herein. Examples of alkylsulfonyloxy include, but are not limited to methylsulfonyloxy, trifluoromethylsulfonyloxy, propylsulfonyloxy, and the like. "Optional" or "optionally" means that the subsequently described event or circumstance may but need not occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not. For example, "optional bond" means that the bond may or may not be present, and that the description includes single, double, or triple bonds. "Leaving group" means the group with the meaning conventionally associated with it in synthetic organic chemistry, i.e., an atom or group displaceable under alkylating conditions. Examples of leaving groups include, but are not limited to, halogen, alkane- or arylsulfonyloxy, such as methanesulfonyloxy, ethanesulfonyloxy, thiomethyl, benzenesulfonyloxy, tosyloxy, and thienyloxy, dihalogenphosphinoyloxy, optionally substituted benzyloxy, isopropyloxy, acyloxy, and the like. "Protective group" or "protecting group" means the group which selectively blocks one reactive site in a multifunctional compound such that a chemical reaction can be carried out selectively at another unprotected reactive site in the meaning conventionally associated with it in synthetic chemistry. Certain processes of this invention rely upon the protective groups to block reactive oxygen atoms present in the reactants. Acceptable protective groups for alcoholic or phenolic hydroxyl groups, which may be removed successively and selectively includes groups protected as acetates, halogenalkyl carbonates, benzyl ethers, alkylsilyl ethers, heterocyclyl ethers, and methyl or alkyl ethers, and the like. Protective or blocking groups for carboxyl groups are similar to those described for hydroxyl groups, preferably tert-butyl, benzyl or methyl esters. Examples of protecting groups can be found in T.W. Greene et al, Protective Groups in Organic Chemistry, (J. Wiley, 2 nd ed. 1991) and Harrison et al., Compendium of Synthetic Organic Methods, Vols. 1-8 (J. Wiley and Sons 1971-1996). "Amino-protecting group" means the protecting group that refers to those organic groups intended to protect the nitrogen atom against undesirable reactions during synthetic procedures and includes, but is not limited to, benzyl, benzyloxycarbonyl (carbobenzyloxy, CBZ), p-methoxybenzyloxycarbonyl, p-nitrobenzyloxycarbonyl, tert- butoxycarbonyl (BOC), trifluoroacetyl, and the like. It is preferred to use either BOC or CBZ as the amino-protecting group because of the relative ease of removal, for example by mild acids in the case of BOC, e.g., trifluoroacetic acid or hydrochloric acid in ethyl acetate; or by catalytic hydrogenation in the case of CBZ. "Hydroxy-protecting group" means the protecting group that preserves a hydroxy group that otherwise would be modified by certain chemical reactions. Suitable hydroxy- protecting groups include ether-forming groups that can be removed easily after completion of all other reaction steps, such as the benzyl or the trityl group optionally substituted in their phenyl ring. Other suitable hydroxy-protecting groups include alkyl ether groups, the tetrahydropyranyl, sibyl, trialkylsilyl ether groups, and the allyl group. "Deprotection" or "deprotecting" means the process by which a protective group is removed after the selective reaction is completed. Certain protective groups maybe preferred over others due to their convenience or relative ease of removal. Deprotecting reagents for protected hydroxyl or carboxyl groups include potassium or sodium carbonates, lithium hydroxide in alcoholic solutions, zinc in methanol, acetic acid, trifluoroacetic acid, palladium catalysts, or boron tribromide, and the like. "Isomerism" means compounds that have identical molecular formulae but that differ in the nature or the sequence of bonding of their atoms or in the arrangement of their atoms in space. Isomers that differ in the arrangement of their atoms in space are termed "stereoisomers". Stereoisomers that are not mirror images of one another are termed "diastereoisomers", and stereoisomers that are non-superimposable mirror images are termed "enantiomers", or sometimes optical isomers. A carbon atom bonded to four nonidentical substituents is termed a "chiral center". "Chiral isomer" means a compound with one chiral center. It has two enantiomeric forms of opposite chirality and may exist either as an individual enantiomer or as a mixture of enantiomers. A mixture containing equal amounts of individual enantiomeric forms of opposite chirality is termed a "racemic mixture". A compound that has more than one chiral center has 2 n_1 enantiomeric pairs, where n is the number of chiral centers. Compounds with more than one chiral center may exist as either an individual diastereomer or as a mixture of diastereomers, termed a "diastereomeric mixture". When one chiral center is present, a stereoisomer may be characterized by the absolute configuration ( R or S ) of that chiral center. Absolute configuration refers to the arrangement in space of the substituents attached to the chiral center. The substituents attached to the chiral center under consideration are ranked in accordance with the Sequence Rule of Cahn, Ingold and Prelog. (Cahn et al., Angew. Chem. Inter. Edit. 1966, 5, 385; errata 511; Cahn et al., Angew. Chem. 1966, 78, 413; Cahn and Ingold, /. Chem. Soc. 1951 (London), 612; Cahn et al. Experientia 1956, 12, 81; Cahn, /. Chem.Educ. 1964, 41, 116). "Geometric Isomers" means the diastereomers that owe their existence to hindered rotation about double bonds. These configurations are differentiated in their names by the prefixes cis and trans, or Z and E, which indicate that the groups are on the same or opposite side of the double bond in the molecule according to the Cahn-Ingold-Prelog rules. "Atropic isomers" means the isomers owing their existence to restricted rotation caused by hindrance of rotation of large groups about a central bond. "Substantially pure" means at least about 80 mole percent, more preferably at least about 90 mole percent, and most preferably at least about 95 mole percent of the desired enantiomer or stereoisomer is present. "Pharmaceutically acceptable" means that which is useful in preparing a pharmaceutical composition that is generally safe, non- toxic, and neither biologically nor otherwise undesirable and includes that which is acceptable for veterinary as well as human pharmaceutical use. "Pharmaceutically acceptable salts" of a compound means salts that are pharmaceutically acceptable, as defined herein, and that possess the desired pharmacological activity of the parent compound. Such salts include: (1) acid addition salts formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like; or formed with organic acids such as acetic acid, benzenesulfonic acid, benzoic, camphorsulfonic acid, citric acid, ethanesulfonic acid, fumaric acid, glucoheptonic acid, gluconic acid, glutamic acid, glycolic acid, hydroxynaphthoic acid, 2-hydroxyethanesulfonic acid, lactic acid, maleic acid, malic acid, mandelic acid, methanesulfonic acid, muconic acid, 2- naphthalenesulfonic acid, propionic acid, salicylic acid, succinic acid, dibenzoyl-L-tartaric acid, tartaric acid, p-toluenesulfonic acid, trimethylacetic acid, trifluoroacetic acid, and the like; or (2) salts formed when an acidic proton present in the parent compound either is replaced by a metal ion, e.g., an alkali metal ion, an alkaline earth ion, or an aluminum ion; or coordinates with an organic or inorganic base. Acceptable organic bases include diethanolamine, ethanolamine, N-methylglucamine, triethanolamine, tromethamine, and the like. Acceptable inorganic bases include aluminum hydroxide, calcium hydroxide, potassium hydroxide, sodium carbonate and sodium hydroxide. The preferred pharmaceutically acceptable salts are the salts formed from hydrochloric acid, trifluoroacetic acid, dibenzoyl-L-tartaric acid, and phosphoric acid. It should be understood that all references to pharmaceutically acceptable salts include solvent addition forms (solvates) or crystal forms (polymorphs) as defined herein, of the same acid addition salt. "Crystal forms" (or polymorphs) means crystal structures in which a compound can crystallize in different crystal packing arrangements, all of which have the same elemental composition. Different crystal forms usually have different X-ray diffraction patterns, infrared spectra, melting points, density hardness, crystal shape, optical and electrical properties, stability and solubility. Recrystallization solvent, rate of crystallization, storage temperature, and other factors may cause one crystal form to dominate. "Solvates" means solvent addition forms that contain either stoichiometric or non stoichiometric amounts of solvent. Some compounds have a tendency to trap a fixed molar ratio of solvent molecules in the crystalline solid state, thus forming a solvate. If the solvent is water the solvate formed is a hydrate, when the solvent is alcohol, the solvate formed is an alcoholate. Hydrates are formed by the combination of one or more molecules of water with one of the substances in which the water retains its molecular state as H 2 O, such combination being able to form one or more hydrate. "Prodrug" means a pharmacologically inactive form of a compound which must be metabolized in vivo, e.g., by biological fluids or enzymes, after administration to a subject, into a pharmacologically active form of the compound in order to produce the desired pharmacological effect. The prodrug can be metabolized before absorption, during absorption, after absorption, or at a specific site. Although metabolism occurs for many compounds primarily in the liver, almost all other tissues and organs, especially the lung, are able to carry out varying degrees of metabolism. Prodrug forms of compounds maybe utilized, for example, to improve bioavailability, improve subject acceptability such as by masking or reducing unpleasant characteristics such as bitter taste or gastrointestinal irritability, alter solubility such as for intravenous use, provide for prolonged or sustained release or delivery, improve ease of formulation, or provide site-specific delivery of the compound. Prodrugs are described in The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman, Academic Press, San Diego, 1992. Chapter 8: "Prodrugs and Drug delivery Systems" pp.352-401; Design of Prodrugs, edited by H. Bundgaard, Elsevier Science, Amsterdam, 1985; Design ofBiopharmaceutical Properties through Prodrugs andAnalogS Ed. by E. B. Roche, American Pharmaceutical Association, Washington, 1977; and Drug Delivery Systems, ed. by R.L. Juliano, Oxford Univ. Press, Oxford, 1980. "Subject" means mammals and non-mammals. Mammals means any member of the Mammalia class including, but not limited to, humans, non-human primates such as chimpanzees and other apes and monkey species; farm animals such as cattle, horses, sheep, goats, and swine; domestic animals such as rabbits, dogs, and cats; laboratory animals including rodents, such as rats, mice, and guinea pigs; and the like. Examples of non-mammals include, but are not limited to, birds, and the like. "Therapeutically effective amount" means an amount of a compound that, when administered to a subject for treating a disease state, is sufficient to effect such treatment for the disease state. The "therapeutically effective amount" will vary depending on the compound, and disease state being treated, the severity or the disease treated, the age and relative health of the subject, the route and form of administration, the judgement of the attending medical or veterinary practitioner, and other factors. "Pharmacological effect" as used herein encompasses effects produced in the subject that achieve the intended purpose of a therapy. In one preferred embodiment, a pharmacological effect means that primary indications of the subject being treated are prevented, alleviated, or reduced. For example, a pharmacological effect would be one that results in the prevention, alleviation or reduction of primary indications in a treated subject. In another preferred embodiment, a pharmacological effect means that disorders or symptoms of the primary indications of the subject being treated are prevented, alleviated, or reduced. For example, a pharmacological effect would be one that results in the prevention or reduction of primary indications in a treated subject. "Disease state" means any disease, condition, symptom, or indication. "Treating" or "treatment" of a disease state includes: ( 1 ) preventing the disease state, i.e. causing the clinical symptoms of the disease state not to develop in a subject that may be exposed to or predisposed to the disease state, but does not yet experience or display symptoms of the disease state. (2) inhibiting the disease state, i.e., arresting the development of the disease state or its clinical symptoms, or (3) relieving the disease state , i.e., causing temporary or permanent regression of the disease state or its clinical symptoms. "Antagonist" means a molecule such as a compound, a drug, an enzyme inhibitor, or a hormone, that diminishes or prevents the action of another molecule or receptor site. "Disorders of the urinary tract" or "uropathy" used interchangeably with "symptoms of the urinary tract" means the pathologic changes in the urinary tract. Symptoms of the urinary tract include overactive bladder (also known as detrusor hyperactivity), outlet obstruction, outlet insufficiency, and pelvic hypersensitivity. "Overactive bladder" or "Detrusor hyperactivity" includes, but is not limited to, the changes symptomatically manifested as urgency, frequency, reduced bladder capacity, incontinence episodes, and the like; the changes urodynamically manifested as changes in bladder capacity, micturition threshold, unstable bladder contractions, sphincteric spasticity, and the like; and the symptoms usually manifested in detrusor hyperreflexia (neurogenic bladder), in conditions such as outlet obstruction, outlet insufficency, pelvic hypersensitivity, or in idiopathic conditions such as detrusor instability, and the like. "Outlet obstruction" includes, but is not limited to, benign prostatic hypertrophy (BPH), urethral stricture disease, tumors and the like. It is usually symptomatically manifested as obstructive (low flow rates, difficulty in initiating urination, and the like), or irritative (urgency, suprapubic pain, and the like). "Outlet insufficiency" includes, but is not limited to, urethral hypermobility, intrinsic sphincteric deficiency, or mixed incontinence. It is usually symptomatically manifested as stress incontinence. "Pelvic Hypersensitivity" includes but is not limited to, pelvic pain, interstitial (cell) cystitis, prostadynia, prostatis, vulvadynia, urethritis, orchidalgia, and the like. It is symptomatically manifested as pain, inflammation or discomfort referred to the pelvic region, and usually includes symptoms of overactive bladder. Nomenclature: the naming and numbering of the compounds of this invention is illustrated below: In general, the nomenclature used in this Application is based on AUTONOM™, a Beilstein Institute computerized system for the generation of IUPAC systematic nomenclature. For example, a compound of Formula I wherein R 1 is ethanesulfonyl, R and R 3 are H, R 4 is methyl, R 5 is ethyl, n is 3, m is 2, and X, Y, and Z are CH 2 is named: l-(4-{[2-(4-ethanesulfonylphenyl)-l-methylethyl]ethylamino}butyl)-azepan-2-one. Similarly, a compound of Formula I wherein R 1 is chloro, R 2 and R 3 are H, R 4 is methyl, R 5 is propyl, n is 2, m is 1, X is N and Y and Z are CH 2 , is named: 1- [3-{ [2-(4- chlorophenyl)-l-methylethyl]propylamino)propyl]-tetrahydro-pyrimidin-2-one. Similarly a compound of Formula I wherein R 1 is methanesulfonyl, R 2 and R are H, R 4 is methyl, R 5 is ethyl, n is 3 , m is 2, X and Z are CH 2 , Y is N-methanesulfonyl is named: l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-4-methane- sulfonyl-[l,4]diazepan-2-one. Among compounds of the present invention set forth in the Summary of the Invention, certain compounds of Formula I, or prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof, are preferred. R 1 , R 2 and R 3 are independently in each occurrence preferably hydrogen, halogen, alkoxy, alkylsulfonyl, or alkylsulfonyloxy, and more preferably hydrogen, methoxy, methylsulfonyl, or methylsulfonyloxy. Another preferred group includes compounds where R 1 and R 2 if adjacent, taken together with the ring to which they are attached form a 5- or 6- membered monocyclic saturated or unsaturated ring optionally containing 0, 1, or 2 ring heteroatoms independently selected from nitrogen, oxygen or sulfur, more preferably R 1 and R 2 if adjacent taken together with the ring to which they are attached form naphthalene, indole, 2,3-dihydrobenzofuran, 2,3-dihydrobenzo[l,4]-dioxin, chromane, benzo[l,3]dioxole, benzo[l,3]oxathiolyl, benzo[l,3]oxathioledioxide, and even more preferably 2,3- dihydrobenzo[l,4]-dioxin. R is independently in each occurrence preferably and more preferably methyl. R 5 is independently in each occurrence preferably lower alkenyl or lower alkynyl, more preferably ethyl, propyl, iso-propyl, allyl or propargyl, and even more preferably ethyl or propyl. m is preferably 0 to 3; more preferably 1 to 2; and even more preferably 2; and n is preferably 1 to 6; more preferably 1 to 3; and even more preferably 3. One of X, Y, or Z is independently in each occurrence preferably -S-, -O-, -CH 2 - or >N-R 6 , most preferably -CH 2 - or >N-R 6 , and even more preferably >NH. Especially preferred are compounds of Formula I, wherein R is methyl. In a more preferred embodiment R 4 is methyl and m is 0. In another preferred embodiment, R 4 is methyl and m is 1. An example for such a compound is 1 - (2- { ethyl- [2- (4-methoxyphenyl) - 1-methylethyl] amino} ethyl) -piperidin-2- one. In a more preferred embodiment R 4 is methyl, m is 1 and Y is >N-R 6 . The following are examples of such compounds: l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-piperazin-2-one; 1 - (4- { [ (S) -2- (4-methanesulfonyl-phenyl)- 1 -methyl-ethyl] -propyl- amino} -butyl) -4- methyl-piperazin-2-one; or N-methyl-4-((S)-2-{[4-(2-oxo-piperazin-l-yl)-butyl]-propyl-amino}-propyl)- benzenesulfonamide. In another preferred embodiment, R 4 is methyl and m is 2, more preferably R 4 is methyl, m is 2, and n is 3. Examples of such compounds are: 1 - (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] amino}butyl) -azepan-2-one; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-[l,4]oxazepan-3- one; or l,l,l-trifluoromethanesulfonic acid 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]- amino}propyl)-phenyl ester. Especially preferred are compounds of Formula I, wherein R 4 is methyl, m is 2 and one of X, Y or Z is >N-R 6 and the others are -CH 2 -. Even more preferably, R 4 is methyl, m is 2 and X is >N-R 6 . In another preferred embodiment, R 4 is methyl, m is 2 and Y is >N-R 6 and in another preferred embodiment, R 4 is methyl, m is 2 and Z is >N-R 6 . Even more preferred are compounds of Formula I, wherein R 4 is methyl, m is 2 and Y is >N-R 6 . The following are examples of such compounds: l-(4-{[(S)-2-(-4-methanesulfonyl-phenyl)-l-methylethyl]propylamino}butyl)- [l,4]diazepan-2-one; l-(4-{ethyl-[(S)-l-methyl-2-(4-trifluoromethyl-phenyl)-ethyl]-amino}-butyl)-[l,4]- diazepan-2-one; or l-(4-{[(S)-2-(4-Methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)-4- methyl- [1,4] diazepan-2-one. Especially preferred are also compounds of formula I, wherein R 4 is methyl, m is 2 and Z is >N-R 6 . The following are examples of such compounds: 4-(4-{allyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-[l,4]diazepan-5- one; 4-(4-{[2-(4-tert-butylphenyl)-l-methylethyl]propylamino}butyl)-[l,4]diazepan-5-one; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-5-oxo- [l,4]diazepane-l-carboxylic acid ethyl ester; 4-(4-{[(S)-2-(4-methanesulfonylphenyl)-l-methyl-ethyl]propylamino}butyl)- [1,4] diazepan-5-one; propane-2-sulfonic acid 4-((S)-2-{[4-(7-oxo-[l,4]-diazepin-l-yl)-butyl]-propyl-amino}- propyl) -phenyl ester; or 4-(4-{[(S)-2-(2,3-dihydro-l,4-benzodioxin-6-yl)-l-methyl-ethyl]-propyl-amino}-butyl)- [ 1 ,4] -diazepan-5-one. In another preferred embodiment, R 4 is methyl, and one of X, Y or Z is -O- or -S-. Other preferred compounds of the present invention include the pharmaceutically acceptable salts of the compounds of the present invention wherein the pharmaceutically acceptable salts are formed from hydrochloric acid, 2,2,2-trifluoroacetic acid, dibenzoyl-L- tartaric acid, sodium, or phosphoric acid, more preferably the salts are formed from hydrochloric acid, 2,2,2-trifluoroacetic acid, or phosphoric acid, or even more preferably the salts are formed from hydrochloric acid. Compounds of the present invention may be made by the methods depicted in the illustrative synthetic reaction schemes shown and described below. The starting materials and reagents used in preparing these compounds generally are either available from commercial suppliers, such as Aldrich Chemical Co., or are prepared by methods known to those skilled in the art following procedures set forth in references such as Fieser and Fieser (1991) Reagents for Organic Synthesis,- Wiley & Sons: New York, , Volumes 1-15; Rodd (1989J Chemistry of Carbon Compounds, Elsevier Science Publishers, Volumes 1-5 and Supplementals; and (1991) Organic ReacήonS Wileγ & Sons: New York, , Volumes 1-40. The following synthetic reaction schemes are merely illustrative of some methods by which the compounds of the present invention may be synthesized, and various modifications to these synthetic reaction schemes maybe made and will be suggested to one skilled in the art having referred to the disclosure contained in this Application. The starting materials and the intermediates of the synthetic reaction schemes may be isolated and purified if desired using conventional techniques, including but not limited to filtration, distillation, crystallization, chromatography, and the like. Such materials may be characterized using conventional means, including physical constants and spectral data. Unless specified to the contrary, the reactions described herein preferably take place at atmospheric pressure over a temperature range from about -78 °C to about 150 °C, more preferably from about 0 °C to about 125 °C, and most preferably and conveniently at about room (or ambient) temperature, e.g., about 20 °C. In general, the compounds of Formula I can be prepared by processes described in the following reaction schemes. Scheme A Scheme A, in general, describes a method of preparing a compound of Formula I wherein X, Y, Z, R 1 , R 2 , R 3 , R 4 , R 5 , m, and n are as described hereinbefore. A compound of Formula I can generally be prepared by coupling a carboxaldehyde 1 with a phenylalkylamine 2 under reductive amination conditions. Suitable reducing conditions include sodium triacetoxyborohydride, sodium cyanoborohydride, titanium isopropoxide and sodium cyanoborohydride, hydrogen and a metal catalyst and hydrogen transferring agents such as cyclohexene, formic acid and its salts, zinc and hydrochloric acid, formic acid, or borane dimethylsulfide followed by treatment with formic acid. Suitable inert organic solvents for the reaction include dichloromethane, 1,2-dichloro- ethane, tetrahydrofuran, alcohols, or ethyl acetate, and the like. Preferably the reaction is carried out under basic conditions with sodium triacetoxyborohydride in 1,2-dichloro- ethane. Reductive amination procedures are described in the chemical literature. For example, /. Org. Chem. 1996, 61, 3849 and Tetrahedron Letters 1996, 37, 3977, describe methods utilizing sodium triacetoxyborohydride as a reagent for the reductive amination of aldehydes with a wide variety of amines. For example, /. Am. Chem. Soc. 1971, 93, 2897 and Org. Synth. Coll. 1988, 6, 499 describe methods utilizing sodium cyanoborohydride as reagent for reductive amination of carbonyl compounds. The conventional starting materials of Scheme A are commercially available or are known to, or can readily be synthesized by those of ordinary skill in the art. For example, the starting carboxaldehyde 1 can readily be synthesized as shown by the following reaction schemes (1), (2), and (3): Scheme (1) a b I A carboxaldehyde 1 wherein X, Y, Z, m, and n are defined as described hereinbefore can be prepared by reacting the amido group of compound a with an alkylating agent of the formula L(CH 2 ) n CH=CH 2 wherein L is a leaving group such as halogen or methanesulfonyloxy, preferably chloro, under basic conditions to obtain a compound b. The alkylation reaction is followed by the oxidation/cleavage of the terminal alkene group of compound b to an aldehyde group to obtain a carboxaldehyde 1. Various oxidizing agents used in the oxidation/cleavage of alkenes to aldehydes are described in the chemical literature. For example, /. Org. Chem. 1956, 21, 478 describes methods utilizing osmium tetroxide and sodium (meta)periodate; Syn. Comm. 1982, 12, 1063 describes methods utilizing potassium permanganate and sodium(meta)periodate; /. Org. Chem. 1987, 52, 3698 describes methods utilizing potassium permanganate and silica gel; Chem. Rev. 1958, 58, 925 describes methods utilizing ozone; /. Org. Chem. 1986, 51, 3213 describes methods utilizing potassium permanganate alone; /. Org. Chem. 1987, 52, 2875 describes methods utilizing sodium (meta)periodate and catalytic ruthenium. Preferably the reaction is carried out with osmium tetroxide and sodium (meta)periodate or ozone. Scheme (2) Alternatively, a carboxaldehyde 1 wherein X, Y, Z, m, and n are defined as described hereinbefore can be prepared by reacting the free amine group of compound a with an alkylating agent of the formula L(CH 2 ) n C(OR) 2 wherein R is (Cι -6 )-alkyl and L is a leaving group such as halogen, preferably bromo, to obtain a compound c. The alkylation reaction is followed by the hydrolysis of the acetal group of compound c under acidic conditions to obtain a carboxaldehyde L Scheme (3) f Alternatively, a carboxaldehyde 1 wherein X, Y, Z, m and n are as described in the Summary of the Invention, can be prepared by treating an aminoacetal d wherein R is (C 1-6 )-alkyl with an appropriate acylating agent such as acylating agents of the formula L(CH 2 ) n COL', or L(CH 2 ) n OCOL', or L(CH 2 ) n N=C=O wherein in each instance L' is a leaving group such as halogen, preferably chloro, to obtain compound e. The acylating reaction is followed by the internal N-alkylation of compound e, and the subsequent hydrolysis of the acetal group of compound f to obtain a carboxaldehyde 1. For example, the starting phenylalkylamine 2 can also readily be synthesized as shown by the following reaction schemes (4), (5), and (6): A phenylalkylamine 2 wherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined as described hereinbefore maybe prepared by reacting the benzaldehyde g with a nitroalkane under Knoevenagel or Henry reaction conditions to obtain compound h, followed by the reduction of the nitro group to an amino group and the reduction of the alkene bond of compound h to obtain a compound i. A phenylalkylamine 2 can be obtained by the subsequent reaction of the free amine group of compound i with an aldehyde RCHO under reductive amination conditions, or with an acylating agent RCOL followed by reduction, (R is a ( ^-alkyl group wherein CH 2 R is R 5 ), or with an alkylating agent R 5 L wherein L is a leaving group such as halogen. Scheme (5) N HR5 3 Alternatively, a phenylalkylamine 2 wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described in the Summary of the Invention may be prepared by reacting bromobenzene j with magnesium metal and an alkenyl halide to obtain compound k, followed by ozonolysis of compound k to obtain compound 1. A phenylalkylamine 2 can be obtained by the subsequent treatment of the compound 1 with a primary amine of the formula R NH 2 under reductive amination conditions. Various methods for the synthesis of a phenylalkylamine 2 are described in the chemical literature, for example, /. Med. Chem. 1973, 6, 480-483; /. Med. Chem. 1986, 29, 2009-2015; and/. Med Chem. 1991, 34, 1662- 1669. R 1 Scheme (6) Alternatively, a phenylalkylamine 2 wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined as described hereinbefore may be prepared by reacting a compound of the general structure n, wherein R is alkyl, aryl or alkylaryl, more preferably R is benzyl and R a and R b are alkyl or alkoxy, or R a and R b together with the nitrogen to which they are attached form a ring, more preferably R a and R form a morpholine ring; with an aryl metal reagent, more preferably an aryl Grignard's reagent of the general structure m to yield the carbamic acid ester of general structure o , wherein R is alkyl, aryl or alkylaryl, more preferably R is benzyl. Reduction with a weak reducing agent such as sodium or lithium borohydride or borane, preferably sodium borohydride followed by a base treatment such as potassium hydroxyde or potassium tert-butoxide, yielded the oxazolidin-2-one p_. The oxazolidinone p_ may be alkylated with an alkyl substituted with a leaving group, preferably with alkylhalide, to give the N-alkyloxazolidinone c[. Cleavage of the oxazolidinone ring of compounds g or Q, by hydrogenolysis may be achieved, for example, with a formate salt, preferably with ammonium formate, and palladium on carbon to yield the corresponding chiral amphetamines of Formula 2 or of Formula 2a. Scheme B Scheme B, in particular, describes a method of preparing a compound of Formula I wherein X, Y, and Z are each -CH 2 -, and R 1 , R 2 , R 3 , R 4 , R 5 , m and n are defined as described hereinbefore. A compound of Formula IA can be prepared by proceeding as described in Scheme B. Preferably, a compound of Formula IA can be prepared by reacting a carboxaldehyde 1 with a phenylalkylamine 2 under reductive amination conditions as described in Scheme B. Exemplary preparations of compounds of Formula I A are given in Example 1. Scheme C Scheme C, in particular, describes a method of preparing a compound of Formula I wherein X is >N-R 6 , -O-, or -S-; Y and Z are each -CH 2 -; and R 1 , R 2 , R 3 , R 4 , R 5 , m and n are defined as described hereinbefore. A compound of Formula IB can be prepared by proceeding as described in Scheme C. Preferably, a compound of Formula IB can be prepared by reacting a carboxaldehyde lb with a phenylalkylamine 2 under reductive amination conditions as described in Scheme C. Exemplary preparations of a compound of Formula IB are given in Example 2. Scheme D Scheme D, in particular, describes a method of preparing a compound of Formula I wherein X and Z are each -CH 2 -; Y is >N-R 6 , -O- or -S-; and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and n are defined as described hereinbefore. A compound of Formula ICa, ICb or ICc can be prepared by proceeding as described in Scheme D. Preferably, a compound of Formula ICa wherein Y is -O- or -S- can be prepared by reacting a carboxaldehyde lc with a phenylalkylamine 2 under reductive amination conditions as described in Scheme D. Alternatively, a compound of Formula ICc wherein Y is >N-R 6 can also be prepared by coupling an nitrogen-protected carboxaldehyde Id wherein P is a suitable nitrogen- protecting group with a phenylalkylamine 2 under reductive amination conditions as described in Scheme A. This reaction is followed by removing the nitrogen-protecting group of compound 3 under acidic conditions to obtain a compound of Formula ICb wherein Y is >NH. The compound of Formula ICb may then be further reacted with an appropriate alkylating agent, acylating agent, or sulfonylating agent by procedures known to one skilled in the art to obtain a compound of Formula ICc wherein R 6 is other than H. Exemplary preparations of a compound of Formula ICa, ICb or ICc are given in Examples 3, 4, and 5. Scheme E Scheme E, in particular, describes a method of preparing a compound of Formula I wherein X and Y are each -CH 2 -, and Z is >N-R 6 , -O- or -S-; and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and n are defined as described hereinbefore. A compound of Formula IDa, IDb or IDc can be prepared by proceeding as described in Scheme E. Preferably, a compound of Formula IDa wherein Z is -O- or -S- can be prepared by reacting a carboxaldehyde le under reductive amination conditions as described in Scheme E. Alternatively, a compound of Formula IDc wherein Z is >N-R 6 can be prepared by coupling an amino-protected carboxaldehyde If wherein P is a suitable nitrogen-protecting group with a phenylalkylamine 2 under reductive amination conditions as described in Scheme E. Alternatively compound 4 can be prepared from an amino-protected carboxaldehyde If by coupling with a phenylalkylamine 2a, followed by reductive alkylation. Removal of the nitrogen-protecting group of compound 4 under acidic conditions can yield a compound of Formula IDb wherein Z is >NH. Optionally the compound of Formula IDb may then be further reacted with an appropriate alkylating agent, acylating agent, or sulfonylating agent by procedures known to one skilled in the art to obtain a compound of Formula IDc wherein R 6 is other than H. Exemplary preparations of a compound of Formula IDa, IDb or IDc are given in Examples 6, 7, and 8. Scheme F Scheme F, in particular, describes a alternate method of preparing a compound of Formula I wherein X, Y, Z, R 1 , R 2 , R 3 , R 4 , R 5 , m, and n are defined as described hereinbefore. A compound of Formula I can be prepared by proceeding as described in Scheme F. Alternatively a compound of Formula I can be prepared by alkylating a suitably substituted oxazolidinone p_ with a compound of general Formula r, wherein L is a leaving group, preferably an halide, to give the N-alkylated oxazolidinone 5. When X, Y or Z are N, the secondary amino group of compound r will be protected by procedures known by the one skilled in the art, as described supra. This reaction is followed by the cleavage of the oxazolidinone ring under hydrogenolysis conditions, for example with a formate salt in the presence of palladium hydroxide, to give the intermediate amine 6. Alkylation of the chain secondary amine of Formula 6 with the appropriate aldehyde under reductive amination conditions as described in Scheme F or with an appropriate alkyl halide gives the desired product of Formula I. When X, Y, or Z are N, the nitrogen protecting group can be removed under acidic conditions. Exemplary preparation of a compound of Formula I by the method of Scheme F is given in Example 9. The compounds of this invention are muscarinic receptor antagonists. Compounds that act as antagonists of muscarinic receptors have been used to treat several disease states associated with improper smooth muscle function. Until recently, most of these compounds have been non-selective for the various muscarinic receptor subtypes, leading to unpleasant anti-cholinergic side-effects such as dry mouth, constipation, blurred vision or tachycardia, the most common of which is dry- mouth that results from muscarinic receptor blockade in the salivary gland. Recently developed M2 or M3 specific antagonists have been shown to have reduced side effects. Evidence suggests that concurrent blockade of M2 and M3 receptors could be therapeutically effective in the treatment of disease states associated with smooth muscle disorders, such as genitourinary tract disorders, respiratory tract disorders, gastrointestinal tract disorders, and smooth muscle disorders. Genitourinary tract disorders treatable with compounds of this invention specifically include overactive bladder or detrusor hyperactivity and its symptoms such as the changes symptomatically manifested as urgency, frequency, reduced bladder capacity, incontinence episodes, and the like; the changes urodynamically manifested as changes in bladder capacity, micturition threshold, unstable bladder contractions, sphincteric spasticity, and the like; and the symptoms usually manifested in detrusor hyperreflexia (neurogenic bladder), in conditions such as outlet obstruction, outlet insufficency, pelvic hypersensitivity, or in idiopathic conditions such as detrusor instability, and the like. Gastrointestinal tract disorders treatable with compounds of this invention specifically include irritable bowel syndrome, diverticular disease, achalasia, gastrointestinal hypermotility disorders, and diarrhea. Respiratory tract disorders treatable with compounds of this invention specifically include chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. These and other therapeutic uses are described, for example, in Goodman & Gilman, (1996) The Pharmacological Basis of Therapeutics, ninth edition, McGraw-Hill, New York, Chapter 26, 601-616; and Coleman, R.A., (1994) Pharmacological Reviews, 46, 205-229. The muscarinic receptor affinity of test compounds can be determined by an in vitro receptor binding assay which utilizes a cell membrane preparation from the Chinese hamster ovary cells expressing the recombinant human muscarinic receptors (M 1 -M 5 ), and is described in more detail in Example 17. The muscarinic antagonist properties of the test compounds can be identified by an in vivo assay which determines inhibitory activity against muscarinic receptor mediated saliva secretion in anesthetized rats, and is described in more detail in the Oxotremorine/Pilocarpine-induced salivation (OIS/PIS) model in anesthetized rats, Example 18. The muscarinic antagonist properties of the test compounds can be identified by an in vivo assay which determines inhibitory activity against muscarinic receptor mediated bladder contraction in anesthetized rats, and is described in more detail in the inhibition of volume-induced contractions assay, Example 19. The muscarinic antagonist properties of the test compounds can be identified by an in vivo assay which determines inhibitory activity against muscarinic receptor mediated bladder contraction and saliva secretion in anesthetized dogs, and is described in more detail in Example 20. The present invention includes pharmaceutical compositions comprising at least one compound of the present invention, or a prodrug, an individual isomer, a racemic or non- racemic mixture of isomers or a pharmaceutically acceptable salt, or solvate thereof together with at least one pharmaceutically acceptable carrier, and optionally other therapeutic and/or prophylactic ingredients. In general, the compounds of the present invention will be administered in a therapeutically effective amount by any of the accepted modes of administration for agents that serve similar utilities. Suitable dosage ranges are typically 1-500 mg daily, preferably 1- 100 mg daily, and most preferably 1-30 mg daily, depending upon numerous factors such as the severity of the disease to be treated, the age and relative health of the subject, the potency of the compound used, the route and form of administration, the indication towards which the administration is directed, and the preferences and experience of the medical practitioner involved. One of ordinary skill in the art of treating such diseases will be able, without undue experimentation and in reliance upon personal knowledge and the disclosure of this Application, to ascertain a therapeutically effective amount of the compounds of the present invention for a given disease. In general, compounds of the present invention will be administered as pharmaceutical formulations including those suitable for oral (including buccal and sub- lingual), rectal, nasal, topical, pulmonary, vaginal, or parenteral (including intramuscular, intraarterial, intrathecal, subcutaneous and intravenous) administration or in a form suitable for administration by inhalation or insufflation. The preferred manner of administration is generally oral using a convenient daily dosage regimen which can be adjusted according to the degree of affliction. A compound or compounds of the present invention, together with one or more conventional adjuvants, carriers, or diluents, ma be placed into the form of pharma- ceutical compositions and unit dosages. The pharmaceutical compositions and unit dosage forms maybe comprised of conventional ingredients in conventional proportions, with or without additional active compounds or principles, and the unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the intended daily dosage range to be employed. The pharmaceutical compositions maybe employed as solids, such as tablets or filled capsules, semisolids, powders, sustained release formulations, or liquids such as solutions, suspensions, emulsions, elixirs, or filled capsules for oral use; or in the form of suppositories for rectal or vaginal administration; or in the form of sterile injectable solutions for parenteral use. Formulations containing about one (1) milligram of active ingredient or, more broadly, about 0.01 to about one hundred (100) milligrams, per tablet, are accordingly suitable representative unit dosage forms. The compounds of the present invention may be formulated in a wide variety of oral administration dosage forms. The pharmaceutical compositions and dosage forms may comprise a compound or compounds of the present invention or pharmaceutically acceptable salts thereof as the active component. The pharmaceutically acceptable carriers may be either solid or liquid. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules. A solid carrier ma be one or more substances which may also act as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. In powders, the carrier generally is a finely divided solid which is a mixture with the finely divided active component. In tablets, the active component generally is mixed with the carrier having the necessary binding capacity in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain from about one (1) to about seventy (70) percent of the active compound. Suitable carriers include but are not limited to magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term "preparation" is intended to include the formulation of the active compound with encapsulating material as carrier, providing a capsule in which the active component, with or without carriers, is surrounded by a carrier, which is in association with it. Similarly, cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges may be as solid forms suitable for oral administration. Other forms suitable for oral administration include liquid form preparations including emulsions, syrups, elixirs, aqueous solutions, aqueous suspensions, or solid form preparations which are intended to be converted shortly before use to liquid form preparations. Emulsions may be prepared in solutions, for example, in aqueous propylene glycol solutions or may contain emulsif ing agents, for example, such as lecithin, sorbitan monooleate, or acacia. Aqueous solutions can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizing, and thickening agents. Aqueous suspensions can be prepared by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, and other well known suspending agents. Solid form preparations include solutions, suspensions, and emulsions, and may contain, in addition to the active component, colorants, flavors, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. The compounds of the present invention maybe formulated for parenteral administration (e.g., by injection, for example bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative. The compositions may take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, for example solutions in aqueous polyethylene glycol. Examples of oily or nonaqueous carriers, diluents, solvents or vehicles include propylene glycol, polyethylene glycol, vegetable oils (e.g., olive oil), and injectable organic esters (e.g., ethyl oleate), and may contain formulatory agents such as preserving, wetting, emulsifying or suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient may be in powder form, obtained by aseptic isolation of sterile solid or by lyophilisation from solution for constitution before use with a suitable vehicle, e.g., sterile, pyrogen-free water. The compounds of the present invention may be formulated for topical administration to the epidermis as ointments, creams or lotions, or as a transdermal patch. Ointments and creams may, for example, be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents. Lotions maybe formulated with an aqueous or oily base and will in general also containing one or more emulsifying agents, stabilizing agents, dispersing agents, suspending agents, thickening agents, or coloring agents. Formulations suitable for topical administration in the mouth include lozenges comprising active agents in a flavored base, usually sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert base such as gelatin and glycerin or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier. The compounds of the present invention may be formulated for administration as suppositories. A low melting wax, such as a mixture of fatty acid glycerides or cocoa butter is first melted and the active component is dispersed homogeneously, for example, by stirring. The molten homogeneous mixture is then poured into convenient sized molds, allowed to cool, and to solidify. The compounds of the present invention may be formulated for nasal administration. The solutions or suspensions are applied directly to the nasal cavity by conventional means, for example, with a dropper, pipette or spray. The formulations may be provided in a single or multidose form. In the latter case of a dropper or pipette, this may be achieved by the patient administering an appropriate, predetermined volume of the solution or suspension. In the case of a spray, this may be achieved for example by means of a metering atomizing spray pump. The compounds of the present invention may be formulated for aerosol administration, particularly to the respiratory tract and including intranasal administration. The compound will generally have a small particle size for example of the order of five (5) microns or less. Such a particle size maybe obtained by means known in the art, for example by micronization. The active ingredient is provided in a pressurized pack with a suitable propellant such as a chlorofluorocarbon (CFC), for example, dichlorodifluoromethane, trichlorofluoromethane, or dichlorotetrafluoroethane, or carbon dioxide or other suitable gas. The aerosol may conveniently also contain a surfactant such as lecithin. The dose of drug maybe controlled by a metered valve. Alternatively the active ingredients may be provided in a form of a dry powder, for example a powder mix of the compound in a suitable powder base such as lactose, starch, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidine (PVP). The powder carrier will form a gel in the nasal cavity. The powder composition may be presented in unit dose form for example in capsules or cartridges of e.g., gelatin or blister packs from which the powder may be administered by means of an inhaler. The compounds of the present invention can be formulated in transdermal or subcutaneous drug delivery devices. These delivery systems are advantageous when sustained release of the compound is necessary and when patient compliance with a treatment regimen is crucial. Compounds in a transdermal delivery systems are frequently attached to an skin-adhesive solid support. The compound of interest can also be combined with a penetration enhancer, e.g., Azone (l-dodecylazacycloheptan-2-one). Sustained release delivery systems are inserted subcutaneously into the subdermal layer by surgery or injection. The subdermal implants encapsulate the compound in a lipid soluble membrane, e.g., silicone rubber, or a biodegradable polymer, e.g., polylacetic acid. The pharmaceutical preparations are preferably in unit dosage forms. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form. Other suitable pharmaceutical carriers and their formulations are described in Remington, The Science and Practice of Pharmacy, 1995, edited by E. W. Martin, Mack Publishing Company, 19th edition, Easton, Pennsylvania. Representative pharmaceutical formulations containing a compound of the present invention are described in Examples 10 to 16. The following preparations and examples are given to enable those skilled in the art to more clearly understand and to practice the present invention. They should not be considered as limiting the scope of the invention, but merely as being illustrative and representative thereof. EXAMPLES ■ Preparation 1 (preparation of a compound of Formula 1) 4- (2-Oxo-azocan- 1 -γl) -butyraldehyde To a stirred suspension of sodium hydride (0.9 g, 37.5 mmole) in dimethyl- formamide (50 mL) was added azocan-2-one (3.83 g, 30 mmole). The mixture was stirred at room temperature for 15 minutes, and then 5-bromo-l-pentene (5.03 g, 33.7 mmole) was added slowly. The reaction mixture was stirred at room temperature for 30 minutes, and then at 80 °C for 16 hours. The solvent was removed under reduced pressure and water was added to the residue. The mixture was extracted with ethyl ether, the organic phase was washed with water, dried (magnesium sulfate) and concentrated to give 1-pent- 4-enyl-azocan-2-one (5.53 g,) as an oil. Osmium tetroxide (17 mg, 0.07 mmole) was added to l-pent-4-enyl-azocan-2-one (5.52 g, 28.3 mmole) in a mixture of tetrahydrofuran (100 mL) and water (50 mL) under ambient water bath cooling. The mixture was stirred for 5 minutes and solid sodium periodate (15.11 g, 70.65 mmole) was added in portions over 15 minutes. The reaction mixture was stirred for 3 hours and filtered. The filtrate was concentrated, saturated with solid sodium chloride, and extracted with methylene chloride. The organic phase was dried (magnesium sulfate) and concentrated. Purification by silica gel chromatography, eluting with chloroform, gave 4-(2-oxo-azocan-l-yl)-butyraldehyde (4.72 g). Similarly, following the procedure as described above, but optionally replacing azocan-2-one with other appropriate compounds of formula a and optionally replacing 5- bromo-1-pentene with other appropriate alkylating agents of the formula L(CH 2 ) n CH=CH 2 wherein L is a leaving group such as halogen, and utilizing modifications known to those skilled in the art, the additional compounds of formula 1 were prepared: 4-(5-oxo-[l,4]oxazepan-4-yl)-butyraldehyde; and 5-oxo-4-(4-oxobutyl)-[l,4]diazepane-l-carboxylic acid tot-butyl ester. Preparation 2 (alternative preparation of a compound of Formula 1) 5-Oxo-4-(4-oxobutyl -[l,4ldiazepane-l-carboxylic acid tot-butyl ester To a suspension of 60% sodium hydride in mineral oil (0.2 g, 5 mmole) in N,N- dimethylformamide (6 mL) was added 5-oxo-[l,4]diazepane-l-carboxylic acid tert-butyl ester (1.0 g, 4.67 mmole). The reaction mixture was warmed at 50 °C for 5 minutes, and then at room temperature for 15 minutes. To the resulting solution was added 4-bromobutyraldehyde dimethyl acetal (0.99 g, 5 mmole). After the reaction mixture was stirred at room temperature for 16 hours, the solvent was removed, and the residue was partitioned between water and ethyl acetate. The organic phase was washed with water, dried (magnesium sulfate), and concentrated. The residue was dissolved in diethyl ether, and the suspension was filtered, and the filtrate was concentrated. Purification by silica gel chromatography, eluting with 2% methanol in chloroform, gave 4-(4,4-dimethoxybutyl)- 5-oxo-[l,4]diazepane-l-carboxylic acid tot-butyl ester (0.8 g,) as a heavy syrup. Nmr: (chloroform-i) δ (ppm) 1.49, s, (9H); 2.64, m, 3H; 3.32, s (3H); 4.37, m, (1H). A solution of 4-(4,4-dimethoxybutyl)-5-oxo-[l,4]diazepane-l-carboxylic acid tert- butyl ester (3 g, 9.08 mmole) in glacial acetic acid containing 0.5 mL water (10 mL) was stirred at room temperature for 24 hours. The solution was concentrated at 35 °C under reduced pressure, and the residue was partitioned between saturated aqueous sodium bicarbonate and diethyl ether. The organic phase was dried (magnesium sulfate), concentrated, and the residue recrystallized from diethyl ether/hexane to give 5-oxo-4-(4- oxobutyl)-[l,4]diazepane-l-carboxylic acid tot-butyl ester (0.85 g,), m.p. 86-87 °C. Preparation 3 (alternative preparation of a compound of Formula 1) (2-oxo-piperidin-l-yl)-acetaldehyde To a stirred mixture of aminoacetaldehyde dimefhylacetal (0.74 g, 7 mmole) in ethyl acetate (20 mL) and 2M sodium carbonate (20 mL) was added 5-chlorovaleryl chloride ( 1.55 g, 10 mmole). The reaction mixture was stirred at ambient temperature for 1 hour. The aqueous layer was separated and extracted with ethyl acetate. The combined organic phase was washed with 1% hydrochloric acid and water, dried (magnesium sulfate), and concentrated. The oily residue was dissolved in tetrahydrofuran, and sodium hydride (60% in oil) (0.3 g, 7.5 mmole) was added. The reaction mixture was heated under reflux for 1.5 hours and filtered. The filtrate was concentrated to give l-(2,2-dimethoxyethyl)-piperidin- 2-one (1.06 g) as a pale yellow oil. A mixture of l-(2,2-dimethoxyethyl)-piperidin-2-one (1.06 g, 5.67 mmole) in 5% aqueous tetrahydrofuran (20 mL) was heated under reflux for 1 hour. The mixture was dried with anhydrous magnesium sulfate, filtered, and concentrated to give (2-oxo- piperidin-l-yl)-acetaldehyde (0.69 g) as a pale yellow oil. 4-(2-Oxo-[l,3loxazocan-3-yl -butyraldehyde To an ice-cooled solution of 1.93M phosgene in toluene (31 mL, 60 mmole) was added dropwise a solution of 5-chloro-l-pentanol (4.9 g, 40 mmole) and iV,N-diethylaniline (5.97 g, 40 mmole) in toluene (40 mL). The reaction mixture was stirred at ambient temperature for 4 hours. The mixture was filtered, and the filtrate was concentrated. The residue was taken up in ethyl acetate, filtered, and the solution was added dropwise to an ice-cooled solution of 4-aminobutyraldehyde diethylacetal (7.09 g, 44 mmole) and triethylamine (4.45 g, 44 mmole) in ethyl acetate (60 mL). The reaction mixture was stirred at room temperature for 15 hours, filtered and concentrated. Purification by silica gel chromatography, eluting with 10% ethyl acetate in hexane, gave (4,4-diefhoxybutyl)carbamic acid 5-chloro-pentyl ester (11.4 g,) as an oil. To a solution of (4,4-diethoxybutyl)carbamic acid 5-chloro-pentyl ester (11.4 g, 44 mmole) dissolved in N,N- dimethylformamide (100 mL) was added de-oiled sodium hydride (1.01 g, 42.3 mmole). The reaction mixture was stirred for 15 hours at room temperature, and then at 70 °C for 3 hours. The mixture was diluted with water, saturated aqueous sodium chloride was added, and extracted with ethyl ether. The organic phase was washed with water, dried (magnesium sulfate), and concentrated. Purification by silica gel chromatography, gave 3-(4,4-diethoxybutyl)-[l,3]oxazocan-2-one (2.03 g) as a viscous oil. A mixture of 3-(4,4-diethoxybutyl)-[l,3]oxazocan-2-one (2 g, 7.3 mmole) and 1.5 g Dowex 50W2-200 ion exchange resin in 3% aqueous tetrahydrofuran (30 mL) was heated under reflux for 24 hours. The mixture was filtered, and the filtrate was concentrated and dissolved in dichloromethane. The solution was dried with magnesium sulfate and concentrated to give 4-(2-oxo-[l,3]oxazocan-3-yl)-butyraldehyde (1.45 g) as a viscous oil which solidified. 3-(2-Oxo-tetrahydropyrimidin-l-yl)-propionaldehyde To a stirred and ice-cooled solution of 3-aminopropionaldehyde diethylacetal (5.88 g, 40 mmole) in diethyl ether (35 mL) was added dropwise 3-chloropropyl isocyanate (4.78 g, 40 mmole). The reaction mixture was stirred at room temperature for 4 hours. The mixture was concentrated and dissolved in N,N- dimethylformamide (40 L). To this solution was added de-oiled sodium hydride (0.96 g, 40 mmole). The reaction mixture was stirred at 70 °C for 18 hours, concentrated, taken up in diethyl ether (40 mL), and filtered. The filtrate was concentrated and purified by silica gel chromatography, eluting with hexane-ethyl acetate-methanol (10:9.7:0.3), gave l-(3,3-diethoxypropyl)-tetrahydro- pyrimidin-2-one (9.05 g) as an oil. A mixture of l-(3,3-diethoxypropyl)tetrahydropyrimidin-2-one (1 g, 4.35 mmole), and 1.0 g Dowex 50W2-200 ion exchange resin in 3% aqueous tetrahydrofuran (30 mL) was heated under reflux for 24 hours. The mixture was filtered, the filtrate was concentrated and the residue dissolved in dichloromethane (30 mL), dried with magnesium sulfate, and concentrated to give 3-(2-oxo-tetrahydropyrimidin-l-yl)- propionaldehyde (0.46 g). Preparation 4 (preparation of a compound of Formula 2 (R and R 3 =H, R 2 = t-butyl, R 4 = methyl, R 5 = ethyl) (S)-2-(4-tgr -Butylphenyl)-l-methylethyn-ethylamine Step 1: (S -2-(4-tgrt-Butylphenyl -l-methyl-2-oxoethyn-carbamic acid benzyl ester (o To a suspension of 0.85 g (34.6 mmole) magnesium turnings in 25 mL tetrahydrofuran was added 5 mL of a solution of 5 g (28.8 mmole) l-bromo-4-tot- butylbenzene in 25 mL tetrahydrofuran. One iodine crystal and 1,2-dibromoethane (0.3 mL) was added and the mixture was heated to reflux to initiate the reaction. The rest of the l-bromo-4-tert-butylbenzene solution was then added dropwise and the reaction mixture was stirred at room temperature for 1 hr. The remaining magnesium was allowed to settle and the supernatant was added in portions to a cooled, previously prepared mixture of 8 g (27.4 mmole) ((S)-l-methyl-2-morpholin-4-yl-2-oxoethyl)-carbamic acid benzyl ester n in 30 L tetrahydrofuran and 30 mL (60 mmole) 2M isopropylmagnesium chloride in diethyl ether. The reaction mixture was stirred at room temperature for 16 hrs. The mixture was then added to a well-stirred mixture of 100 mL 5% hydrochloric acid and crushed ice. The mixture was extracted with two 50 mL portions ethyl acetate. The organic phase was washed with 25 mL saturated sodium chloride, dried (magnesium sulfate) and concentrated under reduced pressure. (S)-2-(4-tot-Butylphenyl)-l-methyl-2-oxoethyl]- carbamic acid benzyl ester o was isolated as a solid, 9.2 g. m.p. 156-158 °C. Step 2: (4S,5S~)-5-(4-tot-Butylphenyl)-4-methyl-oxazolidin-2-one (p) To a solution of 9 g (26.5 mmole) [(S)-2-(4-tot-butylphenyl)-l-methyl-2-oxoethyl]- carbamic acid benzyl ester o in 40 mL toluene and 10 mL 2-propanol was added dropwise a solution of .7 g (18.42 mmole) sodium borohydride in 2 mL water containing 1 drop 50% sodium hydroxide. The reaction mixture was stirred at room temperature for 15 hrs. The layers were separated and the organic phase was washed with 25 mL 10% sodium hydroxide. 2-Propanol was removed under reduced pressure and the remaining toluene solution was heated under reflux for 1 hr. The solvent was removed under reduced pressure. The residue was recrystallized from diethyl ether/hexane to provide (4S,5S)-5-(4- tert-butylphenyl)-4-methyl-oxazolidin-2-one p_, 3 g; m.p. 199-200 °C. Similarly, following the procedure described above, the following compounds were prepared: (S)-5-(4-Benzyloxyphenyl)-4-methyl-oxazolidin-2-one. m.p. 138-139°C; (S)-4-methyl-5-(4-trifluoromethylphenyl)-oxazolidin-2-one. m.p. 158-159°C, diethyl ether/hexane; (S)-5-(2,3-dihydrobenzo[l,4]dioxin-6-yl)-4-methyloxazolidin-2-one; M+H=235; and (S)-4-methyl-5-(4-methylsulfanylphenyl)-oxazolidin-2-one; m.p. 112-114°C. Step 3: (4S.5SV5-(4-tert-Butylpheny -4-methyl-3-ethyl-oxazolidin-2-one ( ' q) To a solution of 1 g (4.3 mmole) (4S,5S)-5-(4-tert-butylphenyl)-4-methyl- oxazolidin-2-one p_ in 10 mL N,N-dimethylformamide was added 5.2 mL (5.2 mmole) 1 M potassium terf-butoxide in tetrahydrofuran. To the resulting gel was added 4 L (4.7 mmole) iodoethane. The reaction mixture was heated at 70 °C for 1 hour. Cold water (25 mL) was added and the mixture was extracted with 30 mL ethyl acetate. The organic phase was washed with two 10 mL portions water, dried (magnesium sulfate) and concentrated under reduced pressure. (4S,5S)-5-(4-tot-Butylphenyl)-4-methyl-3-ethyl- oxazolidin-2-one was isolated as a crystalline solid from ethyl acetate/hexane, 1.06 g. M+H=261. Similarly, following the procedure described above, the following compound was prepared: (S)-5-(2,3-dihydrobenzo[l,4]dioxin-6-yl)-4-methyl-3-propyl-oxazolidin-2-one; M+H=277. Step 4: (S -2-(4-tert-Butylphenyl ' )- 1-methylethyn -ethylamine A mixture of 1 g (3.83 mmole) (4S,5S)-5-(4-tot-Butylphenyl)-4-methyl-3-ethyl- oxazolidin-2-one, 2 g (31.74 mmole) ammonium formate and .1 g 10% palladium on carbon in 20 mL methanol was heated under reflux for 2 hours. The mixture was filtered and the filtrate was concentrated under reduced pressure and the residue was partitioned between 10 mL saturated sodium carbonate and 40 mL ethyl acetate. The organic phase was dried (magnesium sulfate) and concentrated under reduced pressure. (S)-2-(4-to - Butylphenyl)- 1-methylethyl] -ethylamine was isolated as the hydrochloride salt from diethyl ether, 0.93 g, m.p.169.4-171.0 °C. Preparation 5 (preparation of a compound of Formula 2) (R 1 , R 3 , and R 5 =H, R 4 = methyl, R 2 = t-Butyl) (S)-2-(4-tert-Butylphenyl)-l-methylethylamine A mixture of 1 g (4.3 mmole) (4S,5S)-5-(4-tot-butylphenyl)-4-mefhyl-oxazolidin-2- one p_( see preparation 4, step 2), 2 g (31.74 mmole) ammonium formate and 0.1 g 10% palladium on carbon in 25 mL methanol was heated under reflux for 2 hrs. The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was partitioned between 10 mL 10% sodium carbonate and 25 mL ethyl acetate. The organic phase was dried (magnesium sulfate) and concentrated under reduced pressure. The title compound was isolated as the hydrochloride salt from diethyl ether, 0.93 g (95%), m.p.259.5-261.3 °C. EXAMPLE 1 (Preparation of a Compound of Formula IA as described in Scheme B) l-(2-{Ethyl-[2-(4-methoxyphenyl)-l-methylethvnaminol-ethyI)-azepan-2-one A mixture of [2-(4-methoxyphenyl)-l-methylethyl]ethylamine (0.53 g, 2.75 mmole), (2-oxo-azepan-l-yl)acetaldehyde (0.5 g, 3.2 mmole), and sodium triacetoxyborohydride (0.88 g, 4.1 mmole) in 1,2-dichloroethane (15 mL) was stirred at room temperature for 60 hours. The mixture was concentrated, and the residue was partitioned between diethyl ether (50 mL) and saturated aqueous sodium bicarbonate (25 mL). The organic solution was extracted with 5% hydrochloric acid (20 mL), and the aqueous acidic phase was washed with diethyl ether and the pH was adjusted to 12 with 25% sodium hydroxide. The mixture was extracted with dichoromethane, and the organic phase was dried (sodium sulfate) and concentrated to give l-(2-{ethyl-[2-(4-methoxyphenyl)-l-methylethyl]- amino}ethyl)-azepan-2-one 11 (0.84 g) as a viscous oil, which was converted to the dibenzoyl-L-tartrate salt, Anal.: Calcd. for C 38 H 46 N 2 Oιo : C, 66.07;H, 6.71; N, 4.06%; Found C, 64.69; H, 6.45; N 3.90%. Similarly, following the procedure described above in Example 1, but optionally replacing (2-oxo-azepan-l-yl)acetaldehyde with other appropriate compounds of formula la, optionally replacing [2-(4-methoxyphenyl)-l-methylethyl]-ethylamine with other appropriate compounds of formula 2, and utilizing modifications known to those skilled in the art, the additional compounds of Formula I wherein X, Y, and Z are each -CH 2 - were prepared: 1 - (2- { ethyl- [2- (4-methoxy-phenyl) - 1 -methylethyl] aminojethyl) -pyrrolidin-2-one, dibenzoyl-L-tartrate salt, 12, Anal.: Calcd. for C 36 H 42 N 2 O 10 : C, 65.24; H, 6.39; N, 4.23%; Found C, 64.75; H, 6.08; N 3.97%; l-(4-{[2-(4-bromo-2,5-dimethoxyphenyl)-l-methylethyl]ethylamino}butyl)-piperidin-2- one, dibenzoyl-L-tartrate salt, 13, m.p. 97-98 °C, M+H = 455; 1 - (2- { ethyl- [2- (4-methoxyphenyl)- 1-methylethyl] amino} ethyl) -piperidin-2-one, dibenzoyl-L-tartrate salt, 14, Anal.: Calcd. for C3 7 H 44 N 2 O 10 : C, 65.67;H, 6.55; N, 4.14%; Found C, 64.86; H, 6.23; N 3.92%; 1 - (3- {ethyl- [2- (4-methoxyphenyl) - 1 -methylethyl] aminojpropyl) -piperidin-2-one, dibenzoyl-L-tartrate salt, 15, Anal.: Calcd. for 0.5 H 2 O : C, 65.22;H, 6.77; N, 4.00%; Found C, 65.37; H, 6.48; N,3.94%; l-(2-{ [2-(4-methoxyphenyl)-l-methylethyl]propylamino}ethyl)-piperidin-2-one dibenzoyl-L-tartrate salt, 16, Anal.: Calcd. for C 38 H 46 N 2 O 10 : C, 66.07;H, 6.71; N, 4.06%; Found C, 65.10; H, 6.29; N3.71%; l-(2-{ethyl-[2-(4-fiuorophenyl)-l-methylethyl]amino}ethyl)-piperidin-2-one, dibenzoyl- L-tartrate salt, 17, m.p. 95-96 °C, M+H = 307; l-(2-{[2-(4-chlorophenyl)-l-methylethyl]ethyIamino}ethyI)-piperidin-2-one, dibenzoyl- L-tartrate salt, 18^ M+H =323; l-(2-{ethyl-[2-(4-trifluoromethoxyphenyl)-l-methylethyl]amino}ethyl)-piperidin-2-one dibenzoyl-L-tartrate salt, 19, Anal.: Calcd. for C 37 H 4 iF 3 N 2 O 10 : C, 60.82; H, 5.66; N, 3.83%; Found C, 60.70; H, 5.46; N 3.56%; 1 - (4- { ethyl- [2- (4-methoxyphenyl) - 1-methylethyl] amino Jbutyl) -piperidin-2-one, dibenzoyl-L-tartrate salt,20, Anal.: Calcd. for C 39 H 8 N 2 O 10 : C, 66.46; H, 6.84; N, 3.97%; Found C, 66.29; H, 6.69; N 4.04%; 1 - (2- { ethyl- [2- (4-isobutoxyphenyl) - 1-methylethyl] amino }ethyl) -piperidin-2-one, dibenzoyl-L-tartrate salt, 21, Anal.: Calcd. for C 4 oH 5 oN 2 O 1 o : C, 66.84; H, 7.01; N, 3.90%; Found C, 66.03; H, 6.76; N 3.74%; l-(2-{ [2-(3-phenoxyphenyl)-l-methylethyl]propylamino}ethyl)-piperidin-2-one, dibenzoyl-L-tartrate salt, 22, Anal.: Calcd. for C4 3 H 48 N 2 O 10 : C, 68.60; H, 6.43; N, 3.72%; Found C, 67.56; H, 6.23; N 3.48%; l-(2-{isobutyl-[2-(4-methoxyphenyl)-l-methylethyl]amino}ethyl)-piperidin-2-one, dibenzoyl-L-tartrate salt, 23, M+H = 347; l-{2- [2-naphthalen-2-yl)-l-methylethyl]propylamino}ethyl)-piperidin-2-one, dibenzoyl- L-tartrate salt, 24, Anal.: Calcd. for C 41 H4 6 N 2 O 9 : C, 69.28; H, 6.52; N, 3.94%; Found C, 67.58; H, 6.16; N 3.48%; l-(2-{[2-(6-methoxynaphthalen-2-yl)-l-methylethyl]propylamino}ethyl)-piperidin-2-one, hydrochloride salt, 25, Anal.: Calcd. for C 2 4H35C1N 2 O 9 .0.4 H 2 O: C, 67.63; H, 8.47; N, 6.69%; Found C, 67,42; H, 8.30; N 6.63%; l-(2-{[2-(4-chlorophenyl)-l-methylethyl]propylamino}ethyl)-piperidin-2-one, dibenzoyl- L-tartrate salt, 26, M+H = 377; 1 - (4- { [2 - (4- chlorophenyl) - 1 -methylethyl] propylamino }butyl) -piperidin-2-one, dib enzoyl- L-tartrate salt, 27, M+H=365; diethylcarbamic acid 4-(2-{ethyl- [2-(2-oxo-piperidin- l-yl)ethyl] amino}propyl)-phenyl ester, dibenzoyl-L-tartrate salt, 28, M+H=404; dimethylcarbamic acid 4-(2-{ethyl-[2-(2-oxo-piperidin-l-yl)ethyl]amino}-propyl)-phenyl ester, dibenzoyl-L-tartrate salt, 29, M+H=321; propane-2-sulfonic acid 4- (2- { ethyl- [2- (2-oxo-piperidin- 1 -yl)ethyl] amino}ethyl) -phenyl ester, dibenzoyl-L-tartrate salt, 30, M+H=411; l-(2-{ethyl- [2- (4-hydroxyphenyl)- 1-methylethyl] amino}ethyl)-piperidin-2-one, dibenzoyl-L-tartrate salt, 31, M+H=305; isopropylcarbamic acid 4-(2-{ethyl-[2-(2-oxo-piperidin-l-yl)ethyl]amino}-propyl)-phenyl ester, dibenzoyl-L-tartrate salt, 32, M+H=390; l-(4-{ [2-(3-trifluoromethylphenyl)-l-methylethyl]propylamino}butyl)-piperidin-2-one, hydrochloride salt, 33, M+H=399; l-(6-{ethyl-[2-(4-methoxyphenyl)-l-methylethyl]amino}hexyl)-piperidin-2-one, dibenzoyl-L-tartrate salt, 34 > M+H=375; 1 - (4- { [2-(3-chlorophenyl)- 1-methylethyl] propylamino}butyl)-piperidin-2-one, dibenzoyl- L-tartrate salt, 35, Anal.: Calcd. for C, 63.35;H, 6.65; N, 3.79%; Found C, 63.64; H, 6.65; N 3.79%; l-(4-{ [2-(3-fluorophenyl)-l-methylethyl]propylamino}butyl)-piperidin-2-one, dibenzoyl- L-tartrate salt, 36, M+H=349; 1 - (4- { [2- (4-bromophenyl)- 1 -methylethyl] ethylamino}butyl) -piperidin-2-one, dibenzoyl- L-tartrate salt, 37, M+H=395; l-(5-{ethyl-[2-(4-methoxyphenyl)-l-methylethyl]amino}pentyl)-piperidin-2-one, hydrochloride salt, 38, M+H=361; l-{4-[2-naphthalen-2yl)-l-methylethyl]propylamino}butyl)-piperidin-2-one, hydrochloride salt, 39, Anal.: Calcd. for C 25 H 37 C1N 2 O.0.8H 2 O: C, 69.60; H, 9.02; N, 6.49%; Found C, 69.69; H, 8.80; N 6.70%; 1 - (4- { [2- (4- tot-butylphenyl) - 1-methylethyl] propylamino Jbutyl) -piperidin-2-one, hydrochloride salt, 40, M+H=387; l-(4-{[2-(2,3-dihydrobenzo[l,4]dioxin-6-yl)-l-methylethyl]propylamino}butyl)- piperidin-2-one, hydrochloride salt, 41, M+H=389; l-(4-{isopropyl-[2-(3-trifluoromethylphenyl)-l-methylethyl]amino}butyl)-piperidin-2- one, hydrochloride salt, 42, M+H=377; 1 - (4- { [2- (2,3-dihydrobenzofuran-5-yl)- 1 -methylethyl] propylamino Jbutyl) -piperidin-2- one, hydrochloride salt, 43 > M+H=373; l-(4-{ [l-(4-chlorobenzyl)propyl]propylamino}butyl)-piperidin-2-one, hydrochloride salt, 44, M+H=379; l-(4-{[l-(3-methoxy-4-methylbenzyl)propyl]propylamino}butyl)-piperidin-2-one, hydrochloride salt, 45, M+H =389; N-[3-(2-{[4-(2-oxo-piperidin-l-yl)butyl]propylamino}propyl)phenyl]- methanesulfonamide, hydrochloride salt, 46, M+H=424; 1 - {4- [ (2- 1 -benzopyran-6-yl- 1 -methylethyl)propylamino] butyl} -piperidin-2-one, hydrochloride salt, 47, M+H=387; l-{4-[(2-benzo[l,3]dioxol-5-yl-l-methylethyl)ethylamino]butyl}-piperidin-2-one, hydrochloride salt, 48, M+H = 361; 1 - (4- { [2- (3-chloro-4- fluorophenyl)- 1 -methylethyl] propylamino }butyl) -piperidin-2-one, hydrochloride salt, 49, M+H = 383; 1- (4- { [2- (4-methylsulfanylphenyl) - 1 -methylethyl] propylamino }butyl) -piperidin-2-one, hydrochloride salt, 50, M+H = 377; l-(4-{isopropyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-piperidin-2- one, hydrochloride salt, 51, M+H = 409; l-(4-{[2-(lH-indol-5-yl)-l-methylethyl]isopropylamino}butyl)-piρeridin-2-one, hydrochloride salt, 52, M+H = 370; 1 - (4- { [2- (2,3-dihydrobenzo [ 1 ,4] dioxin-6-yl)- 1 -methylethyl] isopropylamino} -butyl) - piperidin-2-one, hydrochloride salt, 53, M+H = 389; l-(4-{ [2-(3,3-dimethyl-2,3-dihydrobenzofuran-6-yl)-l-methylethyl]propyl-amino}butyl)- piperidin-2-one, hydrochloride salt, 54, Anal.: Calcd. for C 25 H 41 ClN 2 O 2 : C, 68.70; H, 9.45; N, 6.41%; Found C, 63.93; H, 9.16; N 6.34%; 1 - (4-{ [2- (4-methanesulfonylphenyl) - 1 -methylethyl] propylaminojbutyl) -piperidin-2-one, hydrochloride salt, 55, Anal.: Calcd. for C 22 H 37 ClN 2 O 3 S.1.5H 2 O: C, 55.97; H, 8.54; N, 5.93%; Found C, 55.83; H, 8.21; N 6.70%; 1 - (4- { ethyl- [2- (4-trifluoromethylsulfonylphenyl)- 1 -methylethyl] amino}butyl) -piperidin- 2-one, 2,2,2-trifluoroacetate salt, 56, M+H=449; l-(4-{[2-(4-tert-butylphenyl)-l-methylethyl]ethylamino}butyl)-piperidin-2-one, hydrochloride salt, 57, Anal.: Calcd. for C 24 H 4 ιClN 2 O.0.65H 2 O: C, 68.51; H, 10.13; N, 6.66%; Found C, 68.48; H, 9.92, N 6.85%; propane-2-sulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propylamino}-propyl)-phenyl ester, phosphate salt, 58, Anal: Calcd. for C 25 H 45 N 2 O 8 PS.1.75H 2 O: C, 47.05; H, 7.46; N, 4.39%; Found C, 46.96; H, 7.35; N 4.40%; 4-methanesulfonyl-benzenesulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)- butyl] propylamino Jpropyl) -phenyl ester, 2,2,2-trifluoroacetate salt, 59, M+H=579; benzenesulfonic acid 4-(2-{[4-(2-oxo-azepan-l-yl)butyl]propylamino}propyl)-phenyl ester, 2,2,2-trifluoroacetate salt, 60, M+H=510; 5-benzenesulfonyl-thiophene-2-sulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]- propylamino}propyl)-phenyl ester, 2,2,2-trifluoroacetate salt, 61, M+H=647; butane- 1-sulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propylamino}-propyl)-phenyl ester, 2,2,2-trifluoroacetate salt, 62, M+H=481; 4-chlorobenzenesulfonic acid 4-(2-{[4-(2-oxo-azepan-l-yl)butyl]propyl-amino}propyl)- phenyl ester, 2,2,2-trifluoroacetate salt, 63, M+H=535; 3,4-dimethoxybenzenesulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propyl- amino}propyl)-phenyl ester, 2,2,2-trifiuoroacetate salt,64, M+H=561; ethanesulfonic acid 4-(2-{[4-(2-oxo-azepan-l-yl)butyl]propylamino}propyl)-phenyl ester, 2,2,2-trifluoroacetate salt, 65, M+H=453; dimethylsulfamic acid 4-(2-{[4-(2-oxo-azepan-l-yl)butyl]propylamino}propyl)-phenyl ester, 2,2,2-trifluoroacetate salt, 66, M+H=468; methanesulfonic acid 4-(2-{ [2-(2-oxo-azepan-l-yl)butyl]propylamino}propyl)-phenyl ester, 2,2,2-trifluoroacetate salt, 67, M+H=439; 4-methoxybenzenesulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propyl-amino}propyl)- phenyl ester, 2,2,2-trifluoroacetate salt, 68, M+H=531; naphthalene- 1-sulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propyl-amino}propyl)- phenyl ester, 2,2,2-trifluoroacetate salt, 69, M+H=551; naphthalene-2-sulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propyl-amino}propyl)- phenyl ester, 2,2,2-trifluoroacetate salt, 70, M+H=551; 4-nitrobenzenesulfonic acid 4-(2-{ [2-(2-oxo-azepan-l-yl)butyl]propyl-amino}propyl)- phenyl ester, 2,2,2-trifluoroacetate salt, 71, M+H=546; propane- 1-sulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propylamino}-propyl)-phenyl ester, 2,2,2-trifluoroacetate salt, 72, M+H=467; thiophene-1-sulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propylamino}-propyl)- phenyl ester, 2,2,2-trifluoroacetate salt, 73 > M+H=507; phenylmethanesulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]propylamino}-propyl)- phenyl ester, 2,2,2-trifluoroacetate salt, 74, M+H=515; 4-trifluoromethoxybenzenesulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)butyl]- propylamino}propyl)-phenyl ester, 2,2,2-trifluoroacetate salt, 75, M+H=585; 4-cyanobenzenesulfonic acid 4-(2-{[4-(2-oxo-azepan-l-yl)butyl]propylamino}-propyl)- phenyl ester, 2,2,2-trifluoroacetate salt,76, M+H=526; 1,1,1-trifluoromethanesulfonic acid 4-(2-{ [4-(2-oxo-azepan- l-yl)butyl]propyl- amino}propyl)-phenyl ester, 2,2,2-trifiuoroacetate salt, 77, M+H=493; propane-2-sulfonic acid 4-(2-{ [4-(2-oxo-azepan-l-yl)ethyl]propylamino}-propyl)-phenyl ester, phosophate salt, 78, Anal.: Calcd. for C 23 H 4 iN 2 O 8 PS: C, 51.48; H, 7.70; N, 5.22%; Found C, 45.23; H, 7.12, N 9.45%; 4-methanesulfonyl-iV-[3-(2-{[2-(2-oxo-azepan-l-yl)ethyl]propylamino}propyl)-phenyl]- benzamide, hydrochloride salt, 79, Anal.: Calcd. for C 28 H 4 oClN3O 4 S.0.7H 2 O: C, 59.76; H, 7.41; N, 7.47%; Found C, 59.71; H, 7.20; N 7.44%; 4-methyl-i " -[3-(2-{[2-(2-oxo-azepan-l-yl)ethyl]propylamino}propyl)-phenyl]- benzamide, hydrochloride salt, 80, Anal: Calcd. for C 28 H 4 oClN 3 O 2 .0.7H 2 O: C, 67.44; H, 8.37; N, 8.43%; Found C, 67.32; H, 8.18; N 8.43%; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-azepan-2-one, hydrochloride salt, 81, m.p. 78-79°C, M+H=409; l-(4-{[2-(4-ethanesulfonylphenyl)-l-methylethyl]ethylamino}butyl)-azepan-2-one, hydrochloride salt, 82, M+H=423; l-(4-{ethyl-[2-(4-isopropanesulfonylphenyl)-l-methylethyl]amino}butyl)-azepan-2-one, hydrochloride salt, 83, M+H=437; 4-tert-butyl-N ' -[3-(2-{[4-(2-oxo-azepan-l-yl)butyl]propylamino}propyl)-phenyl]- benzamide, 84, Anal: Calcd. for C 33 H 49 N 3 O 2 : C, 76.26; H, 9.50; N, 8.08%; Found C, 76.32; H, 9.39; N 8.19%; l-(4-{[2-(3-benzenesulfonylphenyl)-l-methylethyl]ethylamino}butyl)-azepan-2-one, hydrochloride salt, 85, M+H=471; l-(4-{[2-(3,3-dimethyl-l,l-dioxo-2,3-dihydro-lff-l-benzo[&]thiophen-5-yl)-l-methyl- ethyl]isopropylamino}butyl)-azepan-2-one, hydrochloride salt, 86, Anal.: Calcd. for C 26 H 437 ClN 2 O 3 S: C, 62.56; H, 8.68; N, 5.61%; Found C, 58.09; H, 8.16; N 5.26%; l-(4-{[2-(4-benzenesulfonylphenyl)-l-methylethyl]ethylamino}butyl)-azepan-2-one, hydrochloride salt, 87, M+H=471; l-(4-{ethyl-[2-(4-(2-methylpropane-l-sulfonyl)phenyl)-l-methylethyl]amino}-butyl)- azepan-2-one, hydrochloride salt, 88, M+H=451; benzo[l,3]dioxole-5-carboxylic acid [2-methanesulfonyl-5-(2-{ [4-(2-oxo-azepan-l- yl)butyl]propylamino}propyl)phenyl] -amide, hydrochloride salt, 89, Anal.: Calcd. for C 3 iH 44 ClN 3 O 6 S.1.9H 2 O: C, 56.72; H, 7.34; N, 6.40%; Found C, 56.79; H, 6.98; N 6.40%; l-(4-{[2-(3,3-dioxo-2,3-dihydrobenzo[l,3]oxathiol-5-yl)-l-methylethyl]- ethylamino}butyl)-azepan-2-one, hydrochloride salt, 90, M+H=423; 1 - (4- { [2- (2,3-dihydrobenzo [ 1 ,3] oxathiol-5-yl) - 1 -methylethyl] isopropylamino} -butyl) - azepan-2-one, hydrochloride salt, 91, M+H=405; l-(4-{ethyl-[2-(3-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-azepan-2-one, hydrochloride salt, 92, M+H=409; l-(4-{[2-(3,3-dioxo-2,3-dihydrobenzo[l,3]oxathiol-5-yl)-l-methylethyl]- isopropylamino}butyl)-azepan-2-one, hydrochloride salt, 93, M+H=437; l-(4-{isopropyl- [2- (4- methanesulfonylphenyl)- 1-methylethyl] amino}butyl)-azepan-2- one, hydrochloride salt, 94, M+H=423; l-(4-{(l-ethylpropyl)-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}-butyl)- azepan-2-one, hydrochloride salt, 95, M+H=451; l-(4-{ [2-(4-methanesulfonylphenyI)- l-methylethyI]propylamino}butyl)-azepan-2-one, hydrochloride salt, 96, M+H=423; 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]amino}propyl)-i ' ,iV-dimethyl- benzenesulfonamide, hydrochloride salt, 97, M+H=438; l-(3-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}propyl)-azepan-2-one, hydrochloride salt, 98, M+H=409; 1- [4-(ethyl-{2- [4-(4-methylpiperazine- l-sulfonyl)phenyl] - l-methylethyl}-amino)butyl] - azepan-2-one, dihydrochloride salt, 99, M+H=493; 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]amino}propyl)-iV-methyl-benzenesulfonamide, hydrochloride salt, 100, M+H=424; l-{4- [ethyl-( l-methyl-2-phenylethyl)amino] -butyl} -azepan-2-one, hydrochloride salt, 101, M+H=331; l-(4-{[2-(3-chloro-4-methanesulfonylphenyl)-l-methylethyl]ethylamino}butyl)-azepan-2- one, hydrochloride salt, 102, Anal.: Calcd. for C 22 H 36 Cl 2 N 2 O 3 S.1.4H 2 O: C, 52.35; H, 7.75; N, 5.55%; Found C, 52.34; H, 7.36; N 5.65%; 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]amino}propyl)-benzenesulfonamide, hydrochloride salt, 103, M+H=410; iV-dimethylethyl-4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]amino}propyl)- benzenesulfonamide, 104, M+H=466; l-(4-{ethyl- [2-(4-trifluoromethanesulfonylphenyl)- 1-methylethyl] -amino}butyl)-azepan- 2-one, hydrochloride salt, 105, M+H=463; 1 - (4- { ethyl- [2- (4-trifluoromethylsulfanylphenyl) - 1 -methylethyl] amino Jbutyl) - azepan-2 - one, hydrochloride salt, 106, M+H=431; l-(4-{ethyl-[2-(4-nitrophenyl)-l-methylethyl]amino}butyl)-azepan-2-one, hydrochloride salt, 107, Anal.: Calcd. for C 2 ιH 34 ClN 3 O 3 .0.7 H 2 O: C, 59.41; H, 8.40; N, 9.90%; Found C, 59.48; H, 8.21; N 9.92%; 1 , 1 , 1-trifluoromethanesulfonic acid 4- (2-{ethyl- [4- (2-oxo-azepan- 1 -yl)butyl] - amino}propyl)-phenyl ester, hydrochloride salt, 108, M+H = 479; iV-[4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]ammo}propyl)phenyl]-l,l,l-trifluoro- methanesulfonamide, sodium salt, 109, Anal.: Calcd. for C 22 H 34 F 3 N 3 NaO 3 S: C, 55.33; H, 7.18, N, 8.80%; Found C, 51.96; H, 6.73; N 8.62%; l-(3-{ethyl-[2-(4-trifluoromethylsulfonylphenyl)-l-methylethyl]amino}propyl)-azepan-2- one, 2,2,2-trifluoroacetate salt, HO, M+H = 449; l-(2-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl]amino}ethyl)-azepan-2- one, 2,2,2-trifluoroacetate salt, 111, M+H = 435; l-[4-(ethyl-{2-[4-(thiazole-2-sulfonyl)phenyl]-l-methylethyl}amino)butyl]-azepan-2-one, hydrochloride salt, 112, Anal.: Calcd. for C 24 H 36 ClN 3 O 3 S 2 .1H 2 O: C, 54.17; H, 7.20; N, 7.90%; Found C, 54.09; H, 6.91 N 7.86%; 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]amino}propyl)-N-isopropyl- benzenesulfonamide, 2,2,2-trifluoroacetate salt, 113, M+H = 452; 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]amino}propyl)-N-(2-hydroxyethyl)- benzenesulfonamide, 2,2,2-trifluoroacetate salt, 114, M+H = 454; 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]amino}propyl)-iV-(2-methoxyethyl)- benzenesulfonamide, 2,2,2-trifluoroacetate salt, 115, M+H = 468; 1- [4-(ethyl-{2- [4-(morpholine-4-sulfonyl)phenyl] - l-methylethyl}amino)butyl] -azepan-2- one, 2,2,2-trifluoroacetate salt, 116, M+H = 480; 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl]amino}propyl)-iV-(2,2,2-trifluoroethyl)- benzenesulfonamide, 2,2,2-trifluoroacetate salt, 117, M+H = 492; l-(4-{ethyl-[2-(4-te7t-butylphenyl)-l-methylethyl]amino}butyl)-azepan-2-one, hydrochloride salt, 118, Anal.: Calcd. for C 25 H 43 C1N 2 O.0.45H 2 O: C, 69.64; H, 8.53; N, 5.55%; Found C, 57.12; H, 8.41 N 5.61%; or 1 - (4- { ethyl- [2- (4-methanesulfonylphenyl)- 1-methylethyl] amino }butyl) -azocan-2-one, hydrochloride salt, H9, Anal.: Calcd. for C 23 H 39 ClN 2 O 3 S.2H 2 O: C, 55.75; H, 8.14; N, 5.65%; Found C, 55.67; H, 8.52; N 5.43%. EXAMPLE 2 (Preparation of a Compound of Formula IB as Described in Scheme C) 3-(4-{Ethyl- (S)-2-(4-methanesulfonylphenyl ' )-l-methyl-ethyl1amino}butyl - f 1 ,31 oxazinan-2-one To a suspension of ethyl- [(S)-2-(4-methylsulfanylphenyl)- 1-methylethyl] -amine hydrochloride (0.25 g, 1 mmole) in 1,2-dichloroethane (10 mL) was added triethylamine (0.2 mL, 1.5 mmole). To this mixture was added 4-(2-oxo-[l,3]oxazinan-3-yl)-butyr- aldehyde (0.18 g, 1.05 mmole) and sodium triacetoxyborohydride (0.32 g, 1.5 mmole). The reaction mixture was stirred at room temperature for 15 hours, concentrated, and the residue was partitioned between 5% sodium hydroxide (5 mL) and diethyl ether (20 mL). The organic phase was dried (magnesium sulfate) and concentrated to give 3-(4-{ethyl- [(S)-2-(4-methylsulfanyl-phenyl)-l-methylethyl]amino}butyl)-[l,3]oxazinan-2-one (0.33 g,) as a viscous oil. To an ice cooled solution of 3-(4-{ethyl-[(S)-2-(4-methylsulfanylphenyl)-l- methylethyl]amino}butyl)-[l,3]oxazinan-2-one (0.33 g, 0.9 mmole) in methanol (10 mL) was added a solution of potassium peroxymonosulfate (Oxone®) (1.22 g, 1.98 mmole) in water (10 mL). The reaction mixture was stirred at room temperature for 5 hours. Then 1.5M sodium carbonate solution (10 mL) was added and the mixture was extracted with diethyl ether (20 mL). The organic phase was dried (magnesium sulfate) and concentrated. Purification of the residue by silica gel chromatography with 10% ethyl acetate in chloroform, gave 3-(4-{ethyl-[(S)-2-(4-methanesulfonylphenyl)-l-methylethyl]amino}- butyl)- [ 1,3] oxazinan-2-one, 122, (0.17 g) as a colorless oil. Anal.: Calcd. for C 2 oH 33 ClN 2 O 4 S: C, 55.48; H, 7.68; N, 6.47%; Found C, 52.32; H, 7.42; N 5.97. Similarly, following the procedure described above in Example 2, but optionally replacing 4-(2-oxo-[l,3]oxazinan-3-yl)butyraldehyde with other appropriate compounds of formula lb and optionally replacing ethyl- [(S)-2- (4-methylsulfanyl-phenyl)-l- methylethyl] -amine hydrochloride with other appropriate compounds of formula 2, and utilizing modifications known to those skilled in the art, the additional compounds of Formula I wherein X is -O- or -S-, were prepared: 3- (4-{ ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] aminojbutyl) - [ 1 ,3 ] oxazepan-2- one, hydrochloride salt, 123, Anal.: Calcd. for C 2 ιH 35 ClN 2 O 4 S: C, 60.78; H, 8.50; N, 6.75%; Found C, 52.82; H, 7.82; N 5.84%; 3-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-[l,3]oxazepan-2- one, hydrochloride salt, 124, Anal.: Calcd. for C 22 H 37 C1N 2 O 4 S.0.85H 2 O: C, 55.47; H, 8.19; N, 5.88%; Found C, 55.42; H, 7.94; N 5.75%; 3-(4-{isopropyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)- [l,3]oxazepan-2-one, hydrochloride salt, 125, Anal.: Calcd. for C 22 H 37 ClN 2 O 4 S.1.5H 2 O: C, 54.14; H, 8.26; N, 5.74%; Found C, 54.12; H, 7.94; N 5.64%; 3-(4-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl]amino}butyl)- [l,3]oxazepan-2-one, 2,2,2-trifiuoroacetate salt, 126, M+H=465; 3-(4-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl]amino}butyl)- [l,3]oxazinan-2-one, 2,2,2-trifluoroacetate salt, 127, M+H=451; 3-[4-(ethyl-{2-[4-(propane-2-sulfonylmethyl)phenyl]-l-methylethyl}amino)-butyl]- [ l,3]oxazepan-2-one, hydrochloride salt, 128, Anal.: Calcd. for C 24 H 4 iClN 2 O 4 S.0.85H 2 O: C, 57.15; H, 8.53; N, 5.55%; Found C, 57.12; H, 8.41 N 5.61%; 3- (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] aminojbutyl) - [ 1 ,3 ] oxazocan-2- one, hydrochloride salt, 129, Anal.: Calcd. for C 22 H 37 C1N 2 O 4 S.0.95H 2 O: C, 55.26; H, 8.20; N, 5.86%; Found C, 55.26; H, 7.92; N 5.99%; 3-(4-{ethyl-[2-(4-trifluoromethanesulfbnylphenyl)-l-methylethyl]amino}butyl)- [l,3]oxazocan-2-one, 2,2,2-trifluoroacetate salt, 130, M+H=479; or 3-(4-{etiιyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-[l,3]thiazinan-2- one, hydrochloride salt, 131, M+H=413. Similarly, following the procedure described above in Example 2, but optionally replacing 4-(2-oxo- [ 1,3] oxazinan-3-yl)butyraldehyde with other appropriate compounds of formula lb and optionally replacing ethyl- [(S)-2-(4-methylsulfanyl-phenyl)-l- methylethyl] -amine hydrochloride with other appropriate compounds of formula 2, and utilizing modifications known to those skilled in the art, the additional compounds of Formula IB wherein X is >N-R 6 were prepared: 1 - [4-{ ethyl- [2- (4-methoxyphenyl) - 1 -methylethyl] amino)butyl] -tetrahydro-pyrimidin-2- one, dibenzoyl-L-tartrate salt, 134, Anal.: Calcd. for C 38 H 47 N3O 10 : C, 64.67;H, 6.71; N, 5.95%; Found C, 62.96; H, 6.28; N 5.76%; 1- [4-{ethyl- [2-(4-methoxyphenyl)- 1-methylethyl] amino)butyl] -3-methyl- tetrahydropyrimidin-2-one, dibenzoyl-L-tartrate salt, 135, Anal.: Calcd. for C 3 9H 49 N3Oιo.0.9H 2 θ: C, 63.64;H, 6.96; N, 5.71%; Found C, 63.66; H, 6.61; N 5.62%; 3 - [4- { [2 - (3 -trifluoromethylphenyl) - 1-methylethyl] propylamino )butyl] - 1 -methyl- tetrahydropyrimidin-2-one, dibenzoyl-L-tartrate salt, 136, Anal.: Calcd. for C 40 H48F 3 N 3 O 9 : C, 62.25;H, 6.27; N, 5.44%; Found C, 60.64; H, 6.05; N 4.81%; 1 - [4- { [2- ( 3 -trifluoromethylphenyl) - 1-methylethyl] propylamino)butyl] -tetrahydro- pyrimidin-2-one, hydrochloride salt, 137, Anal.: Calcd. for C 2 iH 33 ClF 3 N 3 O 9 .0.8 H 2 O: C, 56.00;H, 7.74; N, 9.33%; Found C, 56.00; H, 7.45; N 9.11%; 3-[4-{[2-naphthalen-2-yl-l-methylethyl]propylamino)butyl]-l-methyl- tetrahydropyrimidin-2-one, hydrochloride salt, 138, Anal.: Calcd. for C 25 H 38 ClN 3 O.1.4H 2 O: C, 65.67; H, 8.99; N, 9.19%; Found C, 65.64; H, 8.99; N 9.19%; l-[3-{[2-(4-chlorophenyl)-l-methylethyl]propylamino)propyl]-tetrahydro-pyrimidin-2- one, hydrochloride salt, 139, Anal.: Calcd. for Ci 9 H 31 Cl 2 N 3 O.1.15H 2 O: C, 55.78; H, 8.20; N, 10.27%; Found C, 55.81; H, 7.93; N 10.25%; 1 - (4- {ethyl- [ (S)-2- (4-methanesulfonylphenyl)- 1 -methylethyl] amino }butyl)- tetrahydropyrimidin-2-one, hydrochloride salt, 140, M+H=396; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methyl-ethyl]amino}butyl)-3-methyl- [l,3]diazepan-2-one, hydrochloride salt, 141, M+H=424; l-(4-{[2-(4-methanesulfonylphenyl)-l-methyl-ethyl]propylamino}butyl)-[l,3]diazepan-2- one, hydrochloride salt, 142, M+H=424; 1 - [4- ( {2- [4- (thiazole-2-sulfonyl)phenyl] - 1 -methylethyl}propylamino)butyl] - tetrahydropyrimidin-2-one, hydrochloride salt, 143, Anal.: Calcd. for C 23 H 35 ClN 4 O 3 S 2 .: C, 53.63; H, 6.85; N, 10.88%; Found C, 48.86; H, 6.42, N 9.84%; or l-[4-(ethyl-{2-[4-(thiazole-2-sulfonyl)phenyl]-l-methylethyl}amino)butyl]- tetrahydropyrimidin-2-one, hydrochloride salt, 144. Anal.: Calcd. for C 22 H 3 3ClN4O 3 S 2 .: C, 52.73; H, 6.64; N, 11.18%; Found C, 48.74; H, 6.31, N 10.33%. EXAMPLE 3 (Preparation of a Compound of Formula ICa as Described in Scheme D) 4-r4-fEthyl-((S -2-r4-(thiazole-2-sulfonyl)phenyll-l-methylethyllamino)butyl1- f 1,4] oxazepan-3-one A mixture of ethyl-{(S)-l-methyl-2-[4-(thiazole-2-sulfonyl)phenyl]ethyl}-amine (0.326 g, 1.02 mmole), 4-(3-oxo-[l,4]oxazepan-4-yl)-butyraldehyde (0.22 g, 1.2 mmole), and sodium triacetoxyborohydride (0.3 g, 1.4 mmole) in 1,2-dichloroethane (10 mL) was stirred at room temperature for 15 hours. The solvent was removed under reduced pressure and the residue was partitioned between 5% hydrochloric acid and diethyl ether. The aqueous phase was brought to pH 12 with 25% sodium hydroxide and the mixture was extracted with dichloromethane. The organic phase was dried (magnesium sulfate) and concentrated to give 4-(4-{ethyl-[2-(4-thiazole-2-sulfonylphenyl)-l-methylethyl]- amino}butyl)-[l,4]oxazepan-3-one, 145, as an oil. Anal.: Calcd. for C 23 H 34 ClN 3 θ 4 S 2 .lH 2 O: C, 51.72; H, 6.79; N, 7.87%; Found C, 51.71; H, 6.49 N 7.82%. Similarly, following the procedure described above in Example 3, but optionally replacing 4-(3-oxo-[l,4]oxazepan-4-yl)-butyraldehyde with other appropriate compounds of formulaic and optionally replacing ethyl-{(S)-l-methyl-2-[4-(thiazole-2- sulfony phenyl] ethyl} -amine with other appropriate compounds of formula 2, and utilizing modifications known to those skilled in the art, the additional compounds of Formula ICa wherein Y is -O- or -S- were prepared: 4-(4-{[2-(4-methanesuIfonylphenyl)-l-methyIethyl]propylamino}butyl)-[l,4]oxazepan-3- one, hydrochloride salt, 146, Anal.: Calcd. for C 22 H 37 ClN 2 O 4 S.1.5H 2 O: C, 54.14; H, 8.26; N, 5.74%; Found C, 54.19; H, 8.26; N 5.85%; or 4- (4- {ethyl- [2- (4-trifluoromethanesulfonylphenyl)- 1 -methylethyl] aminojbutyl)- [l,4]oxazepan-3-one, 2,2,2-trifluoroacetate salt, 147, M+H=465. EXAMPLE 4 (Preparation of a Compound of Formula ICb as described in Scheme D) 1 - (4- { [ (S) -2- ( -4-MefhanesulfonylphenyO - 1 -methylethyl] -propylaminolbutyl)- f 1 ,41 diazepan-2-one A mixture of propyl- [ (S)-2- (4-methanesulfonylphenyl)- 1-methylethyl] -amine hydrochoride (0.50 g, 1.7 mmole), 3-oxo-4-(4-oxobutyl)-[l,4]diazepane-l-carboxylic acid tot-butyl ester (0.5 g, 1.76 mmole), triethylamine (0.24 mL, 1.7 mmole), and sodium triacetoxyborohydride (0.54 g, 2.6 mmole) in 1,2-dichloroethane (20 mL) was stirred at room temperature for 17 hours. The solvent was removed, and the residue was partitioned between ethyl acetate (30 mL) and 5% sodium carbonate (20 mL). The organic phase was dried (magnesium sulfate) and concentrated to give 4-(4-{ [(S)-2-(4-methanesulfonyl- phenyl)- 1 -methylethyl] propylamino}butyl)-3-oxo- [ 1,4] diazepane- 1-carboxylic acid tot- butyl ester, (0.89 g), as a syrup. Nmr (chloroform-d) δ (ppm): .82, t, 3H; .94, d, 3H; 1.46, s, 9H; 3.05, s, 3H; 7.36, d, 2H; 7.83, d, 2H. A mixture of 4- (4- { [ (S)-2- (4-methanesulfonylphenyl) - 1 -methylethyl] -propyl- amino}butyl)-3-oxo-[ 1,4] diazepane- 1-carboxylic acid tot-butyl ester (0.9 g, 1.75 mmole) and 3JV hydrochloric acid (4 mL) was warmed to 50 °C. The reaction mixture was stirred at room temperature for 30 minutes, and the pH was adjusted to 10 with saturated sodium carbonate. The mixture was extracted with ethyl acetate (30 mL), and the organic phase was dried (magnesium sulfate), and concentrated. The residue was dissolved in diethyl ether (10 mL) and 1M hydrogen chloride in diethyl ether (2 mL) was added. The precipitate was collected, washed with diethyl ether and hexane, and dried in vacuo to give l-(4-{[(S)-2-(-4-methanesulfonyl-phenyl)-l-methylethyl]propylamino}butyl)- [1,4] diazepan-2-one, dihydrochloride salt (0.49 g),!49, M+H=424. Similarly, following the procedures described above in Example 4, but optionally replacing 3-oxo-4-(4-oxobutyl)-[l,4]diazepane-l-carboxylic acid tot-butyl ester with other appropriate compounds of formula Id and optionally replacing propyl-[(S)-2-(4- methanesulfonylphenyl)- 1-methylethyl] amine hydrochoride with other appropriate compounds of formula 2, and utilizing modifications known to those skilled in the art, the additional compounds of Formula ICb wherein Y is >NH were prepared: l-(4-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl]amino}butyl)- [l,4]diazepan-2-one, hydrochloride salt, 150, M+H=464; l-(4-{ethyl- [2-(4-thiazole-2-sulfonylphenyl)- 1-methylethyl] aminojbutyl)- [ 1,4] diazepan- 2-one, hydrochloride salt, 151, Anal.: Calcd. for C 23 H 35 ClN 4 θ 3 S 2 .1.25H 2 θ: C, 48.12; H, 6.76; N, 9.76%; Found C, 48.10; H, 6.52, N 9.81%; 1 - (4- { ethyl- [2- (4-trifluoromethanesulfonylphenyl) - 1-methylethyl] amino Jbutyl)- piperazin-2-one, hydrochloride salt, 152, M+H=450; iV-methyl-4-(2-{[4-(2-oxo-piperazin-l-yl)butyl]propylaminoJpropyl)- benzenesulfonamide, hydrochloride salt, 153, M+H=425; 1 - (4- { [2- (4-methanesulfonylphenyl) - 1 -methylethyl] propylamino Jbutyl) -piperazin-2-one, hydrochloride salt, 154, M+H=410; 1 - (4- { [2- (4-thiazole-2-sulfonylphenyl) - 1-methylethyl] propylamino}butyl) -piperazin-2- one, hydrochloride salt, 155, Anal.: Calcd. for C 25 H 35 ClN 4 θ 3 S 2 .1.5H 2 O: C, 48.81; H, 6.66; N, 9.49%; Found C, 48.69; H, 6.54, N 9.64%; 1 - (4-{ [2- (4-thiazole-2-sulfonylphenyl) - 1-methylethyl] propylaminojbutyl) - [ 1 ,4] diazepan- 2-one, hydrochloride salt, 156, Anal.: Calcd. for C 24 H 36 C1N 4 O 3 S 2 .0.75H 2 O: C, 49.78; H, 6.88; N, 9.67%; Found C, 49.74; H, 6.75, N 9.69%; ]V-methyl-4-(2-{[4-(2-oxo-[l,4]diazepan-l-yl)butyl]propylamino}propyl)- benzenesulfonamide, dihydrochloride salt, 157, M+H=439; 1- [4- ( ethyl- { 2- [4- (4-methoxybenzenesulfonyl)phenyl] - 1 -methylethyljamino) - butyl] -[ 1,4] diazepan-2-one, 158, M+H=502; 4-[4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl}propylamino)-butyl]- [l,4]diazepan-2-one, 159, M+H=530; l-(4-{ethyl- [2-(4-trifluoromethylphenyl)-l-methylethyl] aminojbutyl)- [ 1,4] -diazepan-2- one, dihydrochloride hemihydrate salt, 160, Anal.: Calcd. for C 2 ιH 33 ClF 3 N 3 O.0.5H 2 O: C, 52.39; H, 7.33; N, 8.73%; Found C, 52.44; H, 7.32, N 8.58%; or l-(4-{[2-(4-tert--butylphenyl)-l-methylethyl]propylamino}butyl)-piperazin-2-one, hydrochloride salt, 16JL, M+H=374. EXAMPLE 5 (Preparation of a Compound of Formula ICc as described in Scheme D) l-(4-\\(S)-2-( -4-Methanesulfonyl-phenyl - 1 -methylethyl] propylamino Jbutyl) -4-mefhyl- [1,4] diazepan-2-one To a solution of l-(4-{[(S)-2-(4-methanesulfonylphenyl)-l-methylethyl]-propyl- aminoJbutyl-l,4-diazepin-2-one (0.08 g, 0.19 mmole) in tetrahydrofuran (10 mL) was added triethylamine (3 drops) followed by sodium triacetoxyborohydride (0.06 g, 0.3 mmole) and 37% formaldehyde (0.1 mL, 1.2 mmole). The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated, and the residue was partitioned between 5% sodium carbonate and chloroform. The organic phase was dried (magnesium sulfate) and concentrated to give l-(4-{[(S)-2-(4-methanesulfonyl- phenyl) - 1 -methylethyl] propylaminojbutyl) -4-methyl- [ 1 ,4] diazepan-2-one, which was isolated as the dihydrochloride salt from diethyl ether (hygroscopic), (0.07 g), 166, M+H=438. Similarly, following the procedures described above in Example 5, but optionally replacing l-(4-{ [(S)-2-(4-methanesulfonylphenyl)-l-methylethyl] -propylaminojbutyl- 1,4- diazepin-2-one with other free amine compounds of Formula ICb, and optionally replacing formaldehyde with other appropriate acylating, alkylating, or sulfonylating agents, and utilizing modifications known to those skilled in the art, the additional compounds of Formula ICc wherein Y is >N-R 6 were prepared: 4-(4-{ethyl- [2-(4-methanesulfonylphenyl)- 1-methylethyl] amino}butyl)-3-oxo-piρerazine- 1-carboxylic acid tert-butyl ester, 167, M+H=496; l-(4-{ethyl- [2-(4-methanesulfonylphenyl)- 1-methylethyl] amino Jbutyl) -4- methanesulfonylpiperazin-2-one, hydrochloride salt, 168, M+H=474; l-(4-{ethyl- [2-(4-methanesulfonylphenyl)- 1-methylethyl] amino}butyl)-4-(morpholine-4- carbonyl)-piperazin-2-one, hydrochloride salt, 169, M+H=509; 1 - (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1 - methylethyl] amino Jbutyl) -4- methanesulfonyl-[l,4]diazepan-2-one, hydrochloride salt, 170, M+H=488; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-4- methanesulfonyl-4-ethyl-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 171, M+H=438; 1 - (4-{ [2- (4-methanesulfonylphenyl)- 1 -methylethyl] propylamino Jbutyl) -4-acetyl- [l,4]diazepan-2-one, 172, M+H=466; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-4-propionyl- [l,4]diazepan-2-one, 173, M+H=480; 1 - (4- { [2- (4-methanesulfonylphenyl)- 1 -methylethyl] propylaminojbutyl) -4-pentanoyl- [l,4]diazepan-2-one, 174, M+H=508; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-4-(3-cyclo- pentylpropanoyl-[l,4]diazepan-2-one, 175, M+H=548; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-4-(thiophene-2- carbonyl)-[l,4]diazepan-2-one, 176, M+H=534; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-3-oxo- [l,4]diazepane-l-carboxylic acid methyl ester, 177, M+H=482; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-4-benzene- sulfonyl-[l,4]diazepan-2-one, 178, M+H=564; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-4-(thiophene-2- sulfonyl)- [1,4] diazepan-2-one, 179, M+H=570; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-3-oxo- [l,4]diazepane-l-carboxylic acid isopropylamide, 180, M+H=509; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-3-oxo- [ 1,4] diazepane- 1-carboxylic acid butylamide, 181, M+H=523; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-4-benzoyl- [l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 182, M+H=528; 1 - (4-{ [2- (4-methanesulfonylphenyl)- 1-methylethyl] propylamino Jbutyl) -4-phenylacetyl- [l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 183, M+H=542; 1 - (4- { [2- (4-methanesulfonylphenyl) - 1-methylethyl] propylamino Jbutyl)-4- (3-phenyl- propionyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 184, M+H=556; 1 - (4- { [2- (4-methanesulfonylphenyl)- 1 -methylethyl] propylaminojbutyl) -4- (pyridine-3 - carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 185, M+H=529; 1 - (4- { [2- (4-methanesulfonylphenyl) - 1 -methylethyl] propylaminojbutyl) -4- (isoxazole-5- carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 186, M+H=519; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylammo}butyl)-4-(furan-2- carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 187, M+H=518; 1 - (4- { [2- (4-methanesulfonylphenyl) - 1 -methylethyl] propylaminojbutyl) -4- (propane- 1 - sulfonyl)- [ 1,4] diazepan-2-one, 2,2,2-trifluoroacetate salt, 188, M+H=530; 1 - (4- { [2- (4-methanesulfonylphenyl)- 1 -methylethyl] propylaminojbutyl) -4- ( 1 -methyl- 1H- imidazole-4-sulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 189, M+H=568; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-3-oxo- [1,4] diazepane- 1-carboxylic acid methylamide, 2,2,2-trifiuoroacetate salt, 190, M+H =481; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-3-oxo- [1,4] diazepane- 1-carboxylic acid ethylamide, 2,2,2-trifluoroacetate salt, 191, M+H=495; 4- (4- { [2- (4-methanesulfonylphenyl) - 1 -methylethyl] propylaminojbutyl) -3-oxo- [1,4] diazepane- 1-carboxylic acid phenylamide, 2,2,2-trifluoroacetate salt, 192, M+H=543; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-4-methane- sulfonyl- [ 1,4] diazepan-2-one, 2,2,2 -trifluoroacetate salt, 193, M+H=502; l-(4-{[2-(4-thiazole-2-sulfonylphenyl)-l-methylethyl]propylamino}butyl)-4-methyl- piperazin-2-one, hydrochloride salt, 194, Anal.: Calcd. for C 25 H 3 ClN 4 O 3 S .1.8H 2 O: C, 48.20; H, 7.01; N, 9.37%; Found C, 48.25; H, 6.64, N 9.41%; 1 - (4- { ethyl- [2- (4-thiazole-2-sulfonylphenyl) - 1-methylethyl] aminoJbutyl)-4- (pyridine-3- sulfonyl) -piperazin-2-one, hydrochloride salt, 195, Anal.: Calcd. for C 27 H 36 ClN 5 O 5 S 3 .1.25H 2 O: C, 46.25; H, 5.68; N, 9.99%; Found C, 46.26; H, 5.68, N 9.99%; l-(4-{ethyl-[2-(4-lhiazole-2-sulfonylphenyl)-l-methylethyl]amino}butyl)-4-(pyridine-3- sulfonyl) -[1, 4] diazepan-2-one, hydrochloride salt, 196, Anal.: Calcd. for C 28 H 38 C1N 5 O 5 S 2 .1.05H 2 O: C, 47.26; H, 5.82; N, 9.84%; Found C, 47.26; H, 5.65, N 9.81%; l-(4-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl]amino}butyl)-4- (pyridine-3-sulfonyl)piperazin-2-one, hydrochloride monohydrate salt, 197, M+H=511; 1 - (4- {ethyl- [2- (4-trifluoromethanesulfonylphenyl)- 1 -methylethyl] aminoJbutyl)-4- methylpiperazin-2-one, hydrochloride salt, 198, M+H=464; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-4-(pyridine-3- sulfonyl)-[l,4]diazepan-2-one, hydrochloride salt, 199, M+H=551; l-(4-{ethyl-[2-(4-methanesulfonyl)-l-methylethyl]amino}butyl)-4-(pyridine-3-sulfonyl)- piperazin-2-one, hydrochloride monohydrate salt, 200, M+H=537; l-(4-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl]aminoJbutyl)-4- (pyridine-3-sulfonyl)- [1,4] diazepan-2-one, hydrochloride salt, 201, M+H=605; 1 - (4- {ethyl- [2- (4-methanesulfonylphenyl)- 1 -methylethyl] aminojbutyl) -4-trifluoro- methanesulfonyl-[l,4]diazepan-2-one, hydrochloride salt, 202, Anal.: Calcd. for C 22 H 35 C1F 3 N 4 O 5 S.0.75H 2 O: C, 44.66; H, 6.22; N, 7.10%; Found C, 44.66; H, 6.08, N 6.96%; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]aminoJbutyl)-4-thiazol-2- ylmethyl- [1,4] diazepan-2-one, hydrochloride salt, 203, Anal.: Calcd. for C 25 H 39 C1N 4 O 3 S 2 .0.85H 2 O: C, 47.56; H, 6.82; N, 8.87%; Found C, 47.58; H, 6.77, N 9.12%; 1 - (4-{ ethyl- [2- (4-trifluoromethanesulfonylphenyl) - 1-methylethyl] aminojbutyl) -4-thiazol- 2-ylmethyl-[l,4]diazepan-2-one, hydrochloride salt, 204, M+H=561; l-(4-{ethyl-[2-(3-trifluoromethyphenyl)-l-methylethyl]amino}butyl)-4-(pyridine-3- sulfonyl) -piperazin-2-one, hydrochloride salt, 205, M+H=527; 1 - (4- { ethyl- [ 2- (4-trifluor omethanesulfonylphenyl) - 1 -methylethyl] amino Jbutyl) -4- ( 1 - methyl- 1H- imidazole-4- sulfonyl) -piperazin-2-one, hydrochloride salt, 206, M+H=594; 1- (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1 -methylethyl] amino }butyl)-4- (2,2,2-tri- fluoroacetyl)-[l,4]diazepan-2-one, hydrochloride salt, 207, Anal.: Calcd. for C 23 H 37 C1F 3 N 3 O 4 S.1.05H 2 O: C, 49.25; H, 6.67; N, 7.49%; Found C, 48.90; H, 6.27, N 7.47%; l-(4-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl]amino}butyl)-4-(l- methyl-lH-imidazole-4-sulfonyl)-[l,4]diazepan-2-one, hydrochloride salt, 208, M+H=608; l-(4-{ethyl-[2-(3-trifluoromethylphenyl)-l-methylethyl]amino}butyl)-4-(l-methyl-lH- imidazole-4-sulfonyl)-piperazin-2-one, dihydrochloride salt, 209, M+H=530; 1- (4-{ethyl- [2- (4-methanesulfonylphenyl) - 1 -methylethyl] amino Jbutyl) -4- (2,2,2-tri- fiuoroethyl)-[l,4]diazepan-2-one, dihydrochloride salt, 210, Anal.: Calcd. for C 23 H 38 C1 2 F 3 N 3 O 3 S.1.20H 2 O: C, 47.13; H, 6.95; N, 7.17%; Found C, 47.17; H, 6.59, N 7.22%; 1 - (4- { [2- (4-methanesulfonylphenyl)- 1 -methylethyl] propylamino Jbutyl) -4- (2-dimethyl- aminoethanesulfonyl)-[l,4]diazepan-2-one, dihydrochloride salt, 211, M+H=559; 1 - (4- { ethyl- [2- (4-trifluoromethanesulfonylphenyl) - 1 -methylethyl] aminojbutyl) -4- ( 1H- imidazol-4-ylmethyl)-[l,4]diazepan-2-one, hydrochloride salt, 212, M+H=544; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-4-methyl- piperazin-2-one, hydrochloride salt, 213, M+H=424; 1 - (4- { [2- (4-tert-butylphenyl) - 1 -methylethyl] ethylamino Jbutyl) -4- ( 1 -methyl- 1H- imidazole-4-sulfonyl)-[l,4]diazepan-2-one, hydrochloride salt, 214, M+H=532; l-(4-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl] amino Jbutyl)-4-(2- methyl-lH-imidazole-4-sulfonyl)-[l,4]diazepan-2-one, hydrochloride salt, 215, M+H=608; l-(4-{[2-(4-tert-butylphenyl)-l-methylethyl]ethylamino}butyl)-4-(2-methyl-lH- imidazole-4-sulfonyl)-[l,4]diazepan-2-one, hydrochloride salt, 216, M+H=532; 1 - (4- { [2- (4-methanesulfonylphenyl)- 1 -methylethyl] propylaminoJbutyl)-4- (2-imidazol- 1 - ylethanesulfonyl)-[l,4]diazepan-2-one, hydrochloride salt, 217, M+H=582; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylaminoJ-butyl)-4- (3-methoxybenzoyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 218, M+H=664; 1 - (4- ( {2- [ 3- (benzo [ 1 ,3] dioxole-5-sulfonyl)phenyl] - 1 -methylethyl] -propylaminoj-butyl) - 4-(furan-2-carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 219, M+H=624; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylamino}-butyl)-4- (thiophene-2-carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 220, M+H=640; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylaminoJ-butyl)-4- (3-nitrobenzoyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 221, M+H=679; l-(4-({2- [3-(benzo[ 1,3] dioxole-5-sulfonyl)phenyl] - 1-methylethyl] propylamino} -butyl) -4- (pyridine-3-carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 222, M+H=635; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylamino}-butyl)-4- (pyridine-4-carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 223, M+H=635; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylamino}-butyl)-4- (isoxazole-5-carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 224, M+H=625; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylaminoJ-butyl)-4- benzoyl-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 225, M+H=634; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylaminoJ-butyl)-4- (4-methoxybenzoyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 226, M+H=664; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylaminoJ-butyl)-4- (2-chloropyridine-4-carbonyl)-[l,4]diazepan-2-one, 2,2,2 -trifluoroacetate salt, 227, M+H=670; 1- (4-( {2- [3- (benzo [ 1,3 ] dioxole-5-sulfonyl)phenyl] - 1-methylethyl] propylaminoJ-butyl)-4- (3,4-dimethoxybenzoyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 228, M+H=694; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylamino}-butyl)-4- (5-methylisoxazole-3-carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 229, M+H=639; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylamino}-butyl)-4- (thiophene-2-sulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 230, M+H=676; 4- [4-({2- [3-(benzo[ 1,3] dioxole-5-sulfonyl)phenyl] - 1-methylethylJpropylamino) -butyl] -3- oxo- [1,4] diazepane- 1-sulfonic acid dimethylamide, 2,2,2-trifluoroacetate salt, 231, M+H=637; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylaminoJ-butyl)-4- benzenesulfonyl-[l,4]diazepan-2-one, 2,2,2-trifiuoroacetate salt, 232, M+H=670; 1 - (4- ( {2- [3- (benzo [ 1 ,3] dioxole-5-sulfonyl)phenyl] - 1 -methylethyl] propylamino} -butyl) -4- methanesulfonyl- [1,4] diazepan-2-one, 2,2,2-trifluoroacetate salt, 233, M+H=608; 1 - (4- ( { 2- [3- (benzo [ 1 ,3] dioxole-5-sulfonyl)phenyl] - 1 -methylethyl] propylamino} -butyl) -4- (3-nitrobenzenesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 234, M+H=715; l-(4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl]propylamino}-butyl)-4- (1 -methyl- lH-imidazole-4-sulfonyl)-[l, 4] diazepan-2-one, 2,2,2-trifluoroacetate salt, 235, M+H=674; 4- [4- ({2- [3- (benzo [ 1,3] dioxole-5-sulfonyl)phenyl] - 1 -methylethyl}propylamino)-butyl] -3- oxo-[ 1,4] diazepane- 1-carboxylic acid (2-methoxyphenyl)-amide, 2,2,2-trifluoroacetate salt, 236, M+H=679; 4-[4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl}propylamino)-butyl]-3- oxo-[l,4]diazepane-l-carboxylic acid (3-methoxyphenyl)-amide, 2,2,2-trifluoroacetate salt, 237, M+H=679; 4-[4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl}propylamino)-butyl]-3- oxo-[ 1,4] diazepane- 1-carboxylic acid (4-methoxyphenyl)- amide, 2,2,2-tritluoroacetate salt, 238, M+H=679; 4- [4- ( { 2- [3- (benzo [ 1 ,3 ] dioxole-5-sulfonyl)phenyl] - 1 -methylethyl}propylamino) -butyl] -3- oxo-[ 1,4] diazepane- 1-carboxylic acid methylamide, 2,2,2-trifiuoroacetate salt, 239, M+H=587; 4-[4-({2-[3-(benzo[l,3]dioxole-5-sulfonyl)phenyl]-l-methylethyl}propylamino)-butyl]-3- oxo-[ 1,4] diazepane- 1-carboxylic acid (3,4,5-trimethoxyphenyl)-amide, 2,2,2-trifluoro- acetate salt, 240, M+H=739; l-[4-(ethyl-{2-[4-(4-methoxybenzenesulfonyl)phenyl]-l-methylethylJamino)-butyl]-4- (pyridine-3-carbonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 241, M+H=607; l-[4-(ethyl-{2-[4-(4-methoxybenzenesulfonyl)phenyl]-l-methylethylJamino)-butyl]-4- benzoyl-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 242, M+H=606; 1 - [4- (ethyl- {2- [4- (4-methoxybenzenesulfonyI)phenyI] - 1 -methylethyl Jamino)-butyl] -4- ( 1 - methyl-lH-imidazole-4-sulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoro-acetate salt, 243, M+H=646; l-(4-{ethyl-[2-(4-trifluoromethylphenyl)-l-methylethyl]amino}butyl-4-(2-methyl-lH- imidazole-4-sulfonyl)-[l,4]-diazepan-2-one, dihydrochloride salt, 244, Anal.: Calcd. for C 2 5H 37 C1F 3 N 5 O 3 S.1.0H 2 O: C, 47.32; H, 6.35; N, 11.04%; Found C, 47.24; H, 6.11, N 11.21%; 1 - (4- { [2- (4-chlorophenyl)- 1 -methylethyl] ethylamino Jbutyl-4- ( 1 -methyl- lH-imidazole-4- sulfonyl)-[l,4]-diazepan-2-one, hydrochloride salt, 245, M+H=510; l-(4-{[2-(4-methanesulfonylphenyl)-l-methyl-ethyl]propylaminoJbutyl)-4-chloro- methanesulfonyl-[l,4]diazepan-2-one, hydrochloride salt, 246, M+H=536; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]ethylamino}butyl)-4-(2-dimethyl- amino-ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 247, M+H=545; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-4-(2-pyrrolidin-l- yl-ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 248, M+H=571; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]aminoJbutyI)-4-(2-pyrroI-l-yl- ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 249, M+H=567; 1 - (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] amino }butyl)-4- (2-piperazin- 1 - yl-ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 250, M+H=586; 1 - (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1 -methylethyl] aminojbutyl) -4- [2- (4-methyl- piperazin- 1 -yl)-ethanesulfonyl] - [ 1 ,4] diazepan-2-one, 2,2,2-trifluoro-acetate salt, 251, M+H=600; l-(4-{[2-(4-methanesulfonylphenyl)- 1-methylethyl] ethylaminoJbutyl)-4-(2-methylamino- ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 252, M+H=531; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]ethylaminoJbutyl)-4-(2-diethylamino- ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifiuoroacetate salt, 253, M+H=573; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]ethylamino}butyl)-4-(2-isopropyl- amino-ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 254, M+H=559; 1 - (4- { [2- (4-methanesulfonyl-phenyl) - 1 -methylethyl] ethylamino Jbutyl) -4- (2-benzyl- amino-ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 255, M+H=607; 1 - (4- { [2- (4-methanesulfonyl-phenyl) - 1-methylethyl] ethylamino }butyl) -4- (2-benzyl- methylamino-ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 256, M+H=621; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]aminoJbutyl)-4-[2-(2-methoxy- .ethylamino)-ethanesulfonyl]-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 257, M+H=575; {2-[4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}-butyl)-3-oxo- [1,4] diazepane- l-sulfonyl]ethylamino}-acetic acid methyl ester, 2,2,2-trifluoro-acetate salt, 258, M+H=589; 1- (4- { [2- (4-methanesulfonyl-phenyl) - 1 -methylethyl] ethylamino Jbutyl) -4- (2-amino- ethanesulfonyl)-[l,4]diazepan-2-one, 2,2,2-trifluoroacetate salt, 259, M+H=517; 1- (4-{ethyl- [2- (4-methanesulfonyl-phenyl)- 1 -methylethyl] aminoJbutyl)-4- (2- dimethylamino-ethanesulfonyl)-piperazin-2-one, 2,2,2-trifluoroacetate salt, 260, M+H=531; l-(4-{ethyl-[2-(4-methanesulfonyl-phenyl)-l-methylethyl]amino}butyl)-4-(2-diethyl- amino-ethanesulfonyl)-piperazin-2-one, 2,2,2-trifluoroacetate salt, 261, M+H=559; l-(4-{ethyl-[2-(4-methanesulfonyl-phenyl)-l-methylethyl]aminoJbutyl)-4-(2-isopropyl- amino-ethanesulfonyl)-piperazin-2-one, 2,2,2 -trifluoroacetate salt, 262, M+H=545; 1 - (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] aminojbutyl) -4- (2-pyrrolidin- 1 - yl-ethanesulfonyl)-piperazin-2-one, 2,2,2-trifluoroacetate salt, 263, M+H=557; 1 -(4-{ethyl- [2-(4-methanesulfonyl-phenyl)-l -methylethyl] aminoJbutyl)-4-(2-benzyl- amino-ethanesulfonyl)-piperazin-2-one, 2,2,2-trifluoroacetate salt, 264, M+H=593; l-(4-{ethyl-[2-(4-methane-sulfonylphenyl)-l-methylethyl]aminoJbutyl)-4-(2-benzyl- methylamino-ethanesulfonyl)-piperazin-2-one, 2,2,2-trifluoroacetate salt, 265, M+H=607; 1 - (4- {ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] amino Jbutyl) -4- [2- (2-hydroxy- ethylamino)-ethanesulfonyl] -piperazin-2-one, 2,2,2-trifluoroacetate salt, 266, M+H=547; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-4-[2-(2-methoxy- ethylamino) -ethanesulfonyl]-piperazin-2-one, 2,2,2-trifluoroacetate salt, 267, M+H=561; {2-[4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]aminoJbutyl)-3-oxo- piperazine-l-sulfonyl]ethylamino}-acetic acid methyl ester, 2,2,2-trifluoroacetate salt, 268, M+H=575; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-4-(2-piperazin-l- yl-ethanesulfonyl)-piperazin-2-one, 2,2,2-trifluoroacetate salt, 269, M+H=572; l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-4-[2-(4-methyl- piperazin-l-yl)-ethanesulfonyl] -piperazin-2-one, 2,2,2-trifluoroacetate salt, 270,M+H=586; or l-(4-{ethyl-[2-(4-methane-sulfonylphenyl)-l-methylethyl]amino}butyl)-4-(2-amino- ethanesulfonyl)-piperazin-2-one, 2,2,2 -trifluoroacetate salt, 271, M+H=503. EXAMPLE 6 (Preparation of a Compound of Formula IDa as described in Scheme E) 4-(4-{[(SV(4-Methanesulfonylphenyl ' )-l-methylethyl]-propylamino}butyl ' )- l,4]oxazepan-5-one To a mixture of [(S)-2-(4-methanesulfonylphenyl)-l-methylethyl]-propylamine (0.2 g, 0.78 mmole) and 4-(5-oxo-[l,4]oxazepan-4-yl)-butyraldehyde (0.22 g, 1.2 mmole) in 1,2-dichloroethane (8 mL) was added sodium triacetoxyborohydride (0.25 g, 1.17 mmole). The reaction mixture was stirred at room temperature for 15 hours. The mixture was diluted with dichloromethane and washed with 5% sodium hydroxide. The organic phase was dried (magnesium sulfate) and concentrated to give 4-(4-{[(S)-(4-methane- sulfonylphenyl)- 1-methylethyl] -propylaminojbutyl)- [l,4]oxazepan-5-one which was isolated as the hygroscopic hydrochloride salt in diethyl ether, (0.23 g), 273; Anal.: Calcd. for C 25 H 37 ClN 2 O 4 S.1.4H 2 O: C, 54.34; H, 8.25; N, 5.76%; Found C, 54.32; H, 8.03; N 5.98%. Similarly, following the procedure described above in Example 6, but optionally replacing 4-(5-oxo-[l,4]oxazepan-4-yl)-butyraldehyde with other appropriate compounds of formula le and optionally replacing [(S)-2-(4-methane-sulfonylphenyl)-l-methylethyl]- propylamine with other appropriate compounds of formula 2, and utilizing modifications known to those skilled in the art, the additional compounds of Formula IDa wherein Z is -O- or -S- were prepared: 4-tert-butyl-iV-[3-(2-{[4-(5-oxo-[l,4]oxazepan-4-yl)-butyl]propylaminoJpropyl)-phenyl]- benzamide, 274, Anal.: Calcd. for C 32 H 47 N 3 O 3 : C, 73.67; H, 9.08; N, 8.05%; Found C, 73.74; H, 8.99; N 8.23%; or 4- (4-{ ethyl- [2- (4-trifluoromethanesulfonylphenyl) - 1-methylethyl] aminojbutyl) - [l,4]oxazepan-5-one, 2,2,2-trifiuoroacetate salt, 275, M+H=465. EXAMPLE 7 (Preparation of a Compound of Formula IDb as described in Scheme E) 4- (4- { [ ( S)-2- (4-Methanesulfonylphenyl - 1-methylethyl] -propylaminolbutyl - [ 1 ,41 diazepan-5-one A mixture of [(S)-2-(4-methanesulfonylphenyl)- 1-methylethyl] -propylamine hydrochloride (2.05 g, 7.03 mmole), triethylamine (0.98 mL, 7 mmole), 5-oxo-4-(4- oxobutyl)-[l,4]diazepane-l-carboxylic acid tert-butyl ester (2.0 g, 7.03 mmole), and sodium triacetoxyborohydride (2.23 g, 10.5 mmole) in 1,2-dichloroethane (40 mL) was stirred at room temperature for 15 hours. The mixture was concentrated, and the residue was partitioned between diethyl ether and saturated sodium carbonate. The organic phase was dried (magnesium sulfate) and concentrated to give 4-(4-{[(S)-2-(4-methane- sulfonylphenyl)-l-methylethyl]propyl-amino}butyl)-5-oxo-[l,4]diazepane-l-carboxylic acid tert-butyl ester (3.6 g) as a heavy syrup. M+H=524. The hydrochloride salt was recrystallized from acetone/diethyl ether, m.p. 156-158 °C. To 4-(4-{[(S)-2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-5- oxo-[ 1,4] diazepane- 1-carboxylic acid tert-butyl ester (3.7 g, 7.06 mmole) was added 6N hydrochloric acid (7 mL). The reaction mixture was warmed at 50 °C for 1 minute, then stirred at room temperature for 30 minutes. The reaction mixture was brought to pH 10 with saturated sodium carbonate and extracted with ethyl acetate. The organic phase was dried (magnesium sulfate) and concentrated to give 4-(4-{[(S)-2-(4-methanesulfonyl- phenyl)-l-methyl-ethyl]propylaminoJbutyl)-[l,4]diazepan-5-one as the dihydrochloride salt (hygroscopic) from diethyl ether, (2.86 g), 277, M+H = 424. Similarly, following the procedures described above in Example 7, but optionally replacing 5-oxo-4-(4-oxobutyl)-[l,4]diazepane-l-carboxylic acid tert-butyl ester with other appropriate compounds of formula If and optionally replacing [(S)-2-(4-methane- sulfonylphenyl)- 1-methylethyl] -propylamine hydrochloride with other appropriate compounds of formula 2, and utilizing modifications known to those skilled in the art, the additional compounds of Formula IDb wherein Z is >NH were prepared: 4-(4-{ethyl- [2-(4-methanesulfonylphenyl)-l-methylethyl] aminojbutyl)- [ 1,4] diazepan-5- one, hydrochloride salt, 278, M+H=410; 4-(4-{ethyl-[2-(4-trifluoromethanesulfonylphenyl)-l-methylethyl]aminoJbutyl)- [l,4]diazepan-5-one, hydrochloride salt, 279, M+H=464; 4-(4-{[2-(2,3-dihydrobenzo[l,4]dioxin-6-yl)-l-methylethyl]ethylaminoJbutyl)- [l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 280, M+H=390; 4-(4-{[2-(2,3-dihydrobenzo[l,4]dioxin-6-yl)-l-methylethyl]propylamino}butyl)- [l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 28_1, M+H=404; 4- (4- { [2- (4-tert-butylphenyl)- 1-methylethyl] propylamino Jbutyl) - [ 1 ,4] diazepan-5-one, hydrochloride salt, 282, M+H=402; 4- (4- { [2- (3-trifluoromethylphenyl) - 1-methylethyl] propylaminojbutyl) - [ 1 ,4] diazepan-5- one, hydrochloride salt, 283, M+H=414; 4-(4-{ [2-(4-methoxyphenyl)- l-methylethyl]propylamino}butyl)- [ 1,4] diazepan-5-one, hydrochloride salt, 284, M+H=376; 4-(4-{ [2-(4-tert-butylphenyl)- 1-methylethyl] ethylamino Jbutyl)- [1,4] diazepan-5-one, hydrochloride salt, 285, M+H=388; 4- (4- { [2- (4- tot-butylphenyl) - 1-methylethyl] isopropylaminojbutyl) - [ 1 ,4] diazepan-5-one, hydrochloride salt, 286, M+H=402; 4-(4-{[2-(4-propanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-[l,4]diazepan-5- one, hydrochloride salt, 287, Anal: Calcd. for C 24 H 42 C1N 3 O 3 S.0.75H 2 O: C, 53.57; H, 8.34; N, 7.81%; Found C, 53.55; H, 8.19 N 7.91%; 4- [4- ( {2- [4- (propane-2-sulfonyl)phenyl] - 1 -methylethyl}propylamino)butyl] - [l,4]diazepan-5-one, hydrochloride salt, 288, Anal.: Calcd. for C25H44CIN 3 O 3 S.O.95H2O: C, 54.03; H, 8.51; N, 7.56%; Found C, 54.05; H, 8.36 N 7.55%; 4-(4-{[2-(4-ethanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-[l,4]diazepan-5- one, hydrochloride salt, 289, Anal.: Calcd. for C 23 H 0 C1N 3 O 3 S: C, 54.11; H, 8.09; N, 8.23%; Found C, 50.88; H, 7.85, N 7.67%; 4-(4-{[2-(4-naphthalen-2-yl)-l-methylethyl]propylamino}butyl)-[l,4]diazepan-5-one, hydrochloride salt, 290, M+H=396; 4-(4-{ [2-(4-thiazole-2-sulfonylphenyl)- 1-methylethyl] propylaminojbutyl)- [1,4] diazepan- 5-one, hydrochloride salt, 291, Anal.: Calcd. for C 25 H 373 C1N 4 O 3 S 2 .1.35H 2 O: C, 48.86; H, 6.77; N, 9.91%; Found C, 48.89; H, 6.71 N 9.40%; 4- ( - { allyl- [ 2 - (4-methanesulfonylphenyl) - 1-methylethyl] amino Jbutyl) - [ 1 ,4] diazepan- 5 - one, hydrochloride salt, 292, Anal: Calcd. for C 22 H 37 C1N 3 O 3 S.0.8H 2 O: C, 51.92; H, 7.65; N, 8.26%; Found C, 51.82; H, 7.48, N 8.27%; 4-(4-{ [2-(4-isobutoxyphenyl)- l-methylethyl]propylamino}butyl)- [1,4] diazepan-5-one, hydrochloride salt, 293, M+H=418; 4-[4-({2-[4-(2-methylpropane-2-sulfonyl)phenyl]-l-methylethylJpropylamino)-butyl]- [1,4] diazepan-5-one, hydrochloride salt, 294, M+H=452; 4-(4-{ethyl- [2- (4-methanesulfonylphenyl)- 1-methylethyl] aminojbutyl)- [ 1,4] diazepan-5- one, hydrochloride salt, 295, M+H=410; 4- (4- { [2- (4-aminophenyl)- 1-methylethyl] ethylamino Jbutyl)- [l,4]diazepan-5-one, hydrochloride salt, 296, M+H=347; 4-(4-{ethyl- [2-(4-nitrophenyl)- 1-methylethyl] aminojbutyl)- [1,4] diazepan-5-one, hydrochloride salt, 297, M+H=377; 4-(4-{[2-(4-hydroxyphenyl)-l-methylethyl]propylamino}butyl)-[l,4]diazepan-5-one, hydrochloride salt, 298, M+H=362; 4-[4-(ethyl-{2-[4-(thiazole-2-sulfonyl)phenyl]-l-methylethylJamino)butyl]- [l,4]diazepan-5-one, hydrochloride salt, 299, Anal.: Calcd. for C 25 H 35 C1N 4 O 3 S 2 .1.80H 2 O: C, 47.30; H, 6.83; N, 9.59%; Found C, 47.31; H, 6.43, N 9.45%; 4-(2-{ethyl-[4-(7-oxo-[l,4]diazepan-l-yl)-butyl]aminoJpropyl)-benzoic acid methyl ester, hydrochloride salt, 300, Anal: Calcd. for C 22 H 36 C1N 3 O 3 .0.80H 2 O: C, 55.41; H, 8.16; N, 8.81%; Found C, 55.38; H, 8.04, N 8.87%; N- [4-(2-{ethyl- [4-(7-oxo- [ l,4]diazepan-l-yl)butyl] aminoJpropyl)phenyl] - methanesulfonamide, hydrochloride salt, 301, M+H=425; -ethyl-4-2-{ ethyl- [4-(7-oxo- [1,4] oxazepan-l-yl)butyl] amino Jpropyl) -benzamide, 302, Anal.: Calcd. for C 23 H 39 ClN 4 O 2 : C, 58.10; H, 8.48; N, 11.78%; Found C, 52.73; H, 8.10, N 10.80%; 4- [4-(ethyl-{2- [4-(pyrrolidine- 1-carbonyl) phenyl] -l-methylethylJamino)butyl] - [l,4]diazepan-5-one, hydrochloride salt, 303, Anal.: Calcd. for C 25 H 41 ClN 4 O: C, 59.87; H, 8.44; N, 11.17%; Found C, 50.76; H, 7.95, N 9.52%; 4-[4-(ethyl-{2-[4-(2-oxo-piperidin-l-yl)phenyl]-l-methylethylJamino)butyl]- [1,4] diazepan-5-one, hydrochloride salt, 304, M+H=429; 4- [4-({2- [4-(lH-imidazole-2-sulfonyl)phenyl] - l-methylethylJamino)butyl] - [l,4]diazepan-5-one, hydrochloride salt, 305, Anal.: Calcd. for C 25 H 40 C1N 5 O 3 S.0.3H 2 O: C, 49.68; H, 7.10; N, 11.59%; Found C, 49.63; H, 7.00, N 11.62%; ,iV-dimethyl-2-[4-2-{[4-(7-oxo-[l,4]diazepan-l-yl)butyl]propylamino}propyl)- benzenesulfonyl] acetamide, 306, Anal: Calcd. for C 25 H 43 ClN 4 O 4 S.: C, 52.90; H, 7.81; N, 9.87%; Found C, 50.43; H, 7.56, N 9.38%; 4- [4- ({2- [4- (thiazol-2-yloxy)phenyl] - 1 -methylethylJpropylamino)butyl] - [ 1 ,4] diazepan-5- one, hydrochloride salt,307, M+H=445; propane-2-sulfonic acid 4-(2-{ [4-(7-oxo-[l,4]diazepan-l-yl)butyl]propyl-aminoJpropyl)- phenyl ester, hydrochloride salt, 308, M+H=468; 4- [4- ( {2- [4- ( 1 , l-dioxo-isothiazolidin-2-yl)phenyl] - 1 -methylethyl J ethylamino) -butyl] - [l,4]diazepan-5-one, hydrochloride salt, 309, M+H=451; or 4-(4-{ [2-(4-methanesulfonylphenyl)- 1-methylethyl] -prop-2-ynylaminoJbutyl)- [l,4]diazepan-5-one, hydrochloride salt, 310, Anal.: Calcd. for C 22 H 34 ClN 3 O 3 S.: C, 53.65; H, 7.16; N, 8.53%; Found C, 49.57; H, 6.83, N 7.84%. EXAMPLE 8 (Preparation of a Compound of Formula IDc as described in Scheme E) 4- (4-IEthyl- [2- (4-methanesulfonylphenyl - 1 -methylethyl] -amino Jbutyl) - 1 - ( isoxazole-5- carbonyl)- [ 1,41 diazepan-5-one To a mixture of 4-(4-{[(S)-2-(4-methanesulfonylphenyl)-l-methylethyl]-propyl- amino}butyl)-[l,4]diazepan-5-one dihydrochloride (0.15 g, .3 mmole) in toluene (5 mL) and saturated sodium carbonate (2 mL) was added isoxazole-5-carbonyl chloride (0.04 g, 0.31 mmole). The reaction mixture was stirred at room temperature for 4 hours. The mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed with saturated sodium chloride, dried (magnesium sulfate), and concentrated to give 4-(4-{ethyl-[2-(4-methanesulfonyl-phenyl)-l-methylethyl]amino}butyl)-l-(isoxazole- 5-carbonyl)-[l,4]diazepan-5-one as a hygroscopic hydrochloride salt (0.14 g) in ethyl acetate/diethyl ether, 3_16, M+H=505. Similarly, following the procedures described above in Example 8, but optionally replacing 4- (4- { [ (S) -2- (4-methanesulfonylphenyl) - 1-methylethyl] -propylamino Jbutyl) - [l,4]diazepan-5-one dihydrochloride with other free amine compounds of Formula IDb, and optionally replacing isoxazole-5-carbonyl chloride with other appropriate acylating, alkylating, or sulfonylating agents, and utilizing modifications known to those skilled in the art, the additional compounds of Formula I wherein Z is >N-R 6 were prepared: 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-l-benzyl- [l,4]diazepan-5-one, hydrochloride salt, 317, M+H=500; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-l- methanesulfonyl-[l,4]diazepan-5-one, hydrochloride salt, 3_18, M+H=488; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]aminoJbutyl)-5-oxo- [l,4]diazepane-l-carboxylic acid amide, hydrochloride salt, 319, M+H=453; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-5-oxo- [ 1,4] diazepane- 1-carboxylic acid dimethylamide, 2,2,2-trifluoroacetate salt, 320, M+H=481; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-5-oxo- [l,4]diazepane-l-carboxylic acid ethyl ester, 2,2,2-trifluoroacetate salt, 321, M+H=482; 4- (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] aminojbutyl) - 1 - (2-methoxy- acetyl)-[l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 322, M+H=482; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]aminoJbutyl)-l-propionyl- [l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 323, M+H=466; 4- (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] aminojbutyl) - 1 - (furan-2- carbonyl)-[l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 324, M+H=504; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-l-iso-butyryl- [l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 325, M+H=480; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]aminoJbutyl)-l-benzoyl- [l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 326, M+H=514; 4- (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] aminojbutyl) - 1 -cyclobutane- carbonyl-[l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 327, M+H=492; 4- (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] amino Jbutyl)- 1 - (morpholine-4- carbonyl)-[l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 328, M+H=523; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-l-(pyridine-3- carbonyl)-[l,4]diazepan-5-one, 2,2,2-trifluoroacetate salt, 329, M+H=515; 4- (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1-methylethyl] aminojbutyl)- 1 -cyclohexane- carbonyl-[l,4]diazepan-5-one, 2,2,2-trifiuoroacetate salt, 330, M+H=520; 4- (4- { ethyl- [2- (4-methanesulfonylphenyl) - 1 -methylethyl] aminojbutyl) -5-oxo- [ 1,4] diazepane- 1-sulfonic acid dimethylamide, 2,2,2-trifluoroacetate salt, 331, M+H=526; 4-(4-{ethyl- [2- (4-methanesulfonylphenyl)- 1-methylethyl] aminoJbutyl)-5-oxo- [l,4]diazepane-l-carboxylic acid fert-butylamide, 2,2,2-trifluoroacetate salt, 332, M+H=509; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-5-oxo- [ 1,4] diazepane- 1-carboxylic acid phenylamide, 2,2,2-trifluoroacetate salt, 333, M+H=529; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl] amino }butyl)-5-oxo- [ 1,4] diazepane- 1 -carboxylic acid (2-mefhoxyρhenyl)amide, 2,2,2-trifluoroacetate salt, 334, M+H=559; 4-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl]amino}butyl)-l-ethyl- [1,4] diazepan-5-one, 2,2,2-trifluoroacetate salt, 335, M+H=438; l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-4-(isoxazole-5- carbonyl)-[l,4]diazepan-5-one, hydrochloride salt, 336, M+H=519; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-l-methyl- [l,4]diazepan-5-one, hydrochloride salt, 337, M+H=438; 4- (4- { [2- (4-methanesulfonylphenyl) - 1 -methyl-ethyl] propylaminojbutyl)- 1 - (2-amino-3- methylbutyryl)-[l,4]diazepan-5-one, hydrochloride salt, 338, M+H=523; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methyl-ethyl]propylaminoJbutyl)-l-(2-dimethyl- aminoethanesulfonyl)-[l,4]diazepan-5-one, hydrochloride salt, 339, M+H=559; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-5-oxo- [1,4] diazepane- 1 - carboxylic acid phenyl ester, hydrochloride salt, 340, Anal. : Calcd. for C 29 H42ClN 3 O 5 S.: C, 60.04; H, 7.30; N, 7.24%; Found C, 58.80; H, 7.84, N 6.57%; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-5-oxo- [l,4]diazepane-l-carboxylic acid tert-butyl ester, hydrochloride salt, 341, m.p. 156-158 °C; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino]butylJ-5-oxo- [1,4] diazepan- l-yl)-phosphonic acid diethyl ester, hydrochloride salt, 342, M+H=560; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-5-oxo- [l,4]diazepane-l-carboxylic acid ethyl ester, hydrochloride salt, 343, m.p. 135-137 °C; acetic acid 2-[4-(4-{ [2-(4-methanesulfonylphenyl)-l-methylethyl]propyl-aminoJbutyl)-5- oxo-[ 1,4] diazepane- 1-carbonyl] -phenyl ester, hydrochloride salt, 344, M+H=586; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methyl-ethyl]propylamino}butyl)-l-(2-hydroxy- benzoyl)-[l,4]diazepan-5-one, hydrochloride salt, 345, M+H=465; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-5-oxo- [ 1,4] diazepane- 1 -carboxylic acid propyl ester, hydrochloride salt, 346, m.p. 152-154 °C; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-5-oxo- [l,4]diazepane-l-carboxylic acid isobutyl ester, hydrochloride salt, 347, Anal.: Calcd. for C 27 H4 6 C1N 3 O 5 S.1.80H 2 O: C, 57.89; H, 8.28; N, 7.50%; Found C, 57.59; H, 8.20, N 7.39%; 4- (4- { [2- (4-methanesulfonylphenyl) - 1-methylethyl] propylamino Jbutyl) -5-oxo- [1,4] diazepane- 1 -carboxylic acid 2,2-dimethylpropyl ester, hydrochloride salt, 348, M+H=538; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylaminoJbutyl)-5-oxo- [1,4] diazepane- 1 -carboxylic acid butyl ester, hydrochloride salt, 349, M+H=524; 4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)-5-oxo- [ 1,4] diazepane- 1-carbaldehyde, hydrochloride salt, 350, M+H=452; 4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)-5-oxo- [1,4] diazepane- 1-carboxylic acid isopropyl ester, hydrochloride salt, 351, mp. 142-143 °C; l-acetyl-4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)- [l,4]diazepan-5-one, hydrochloride salt, 352, M+H=466; acetic acid 2-[4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}- butyl)-5-oxo-[l,4]diazepane-l-carbonyl]-benzyl ester, hydrochloride salt, 353, M+H=600; 4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-aminoJ-butyl)-l-(4- trifluoromethyl-benzyl)-[l,4]diazepan-5-one, hydrochloride salt, 354, M+H=582; acetic acid 4- [4- (4- { [2- (4-methanesulfonyl- phenyl) - 1 -methyl-ethyl] -propyl- amino } - butyl)-5-oxo-[l,4]diazepan-l-ylmethyl]-phenyl ester, hydrochloride salt, 355, M+H=572; 4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)-l-[2-(3- trifluoromethyl-phenyl)-ethyl]-[l,4]diazepan-5-one, hydrochloride salt, 356, M+H=596; l-[2-(4-chloro-phenyl)-ethyl]-4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]- propyl-amino}-butyl)-[l,4]diazepan-5-one, hydrochloride salt, 357, M+H=562; 4-(4-{ [2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl] -propyl-aminoJ-butyl)-l-(2- methoxy-acetyl)-[l,4]diazepan-5-one; 358, M+H=496; l-(2-isopropoxy-acetyl)-4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl- aminoJ-butyl)-[l,4]diazepan-5-one; 359, M+H=524; 4-(4-{ [2-(4-methanesulfonyl-phenyl)- 1-methyl-ethyl] -propyl-aminoJ-butyl)-5-oxo- [l,4]diazepane-l-carboxylic acid benzoylsulfanylmethyl ester; 360, M+H=618; 4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)-5-oxo- [l,4]diazepane-l-carboxylic acid acetoxymethyl ester; 361, mp. 143-144 °C; 4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)-5-oxo- [ 1,4] diazepane- 1 -carboxylic acid 2,2-dimethyl-propionyloxymethyl ester; 362, mp. 129- 130 °C; 4-(4-{[2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-aminoJ-butyl)-5-oxo- [l,4]diazepane-l-carboxylic acid 5-methyl-2-oxo-[l,3]dioxol-4-ylmethyl ester; 363, M+H=580; 4- (4- { [2- (4-methanesulfonyl-phenyl) - 1-methyl-ethyl] -propyl- amino } -butyl) - 5-oxo- [l,4]diazepane-l-carboxylic acid acetylsulfanylmethyl ester; 364, mp. 142-144 °C. EXAMPLE 9 (Alternate preparation of compounds of Formula I as described in Scheme F) 4-(4-{[(S)-2-(4-Methanesulfonyl-phenyl -l-methyl-ethyl1-propyl-aminoJ-butyl)-5-oxo- [ 1,4] diazepane- 1 -carboxylic acid tert-butyl ester Step 1: 4-{4-[5-(4-methanesulfonyl-phenyl)-4-methyl-2-oxo-oxazolidin-3-yl1-propy -5-oxo- [l,4ldiazepane-l-carboxylic acid tert-butyl ester. To a cooled mixture of 2.5 g of 5-(4-methanesulfonyl-phenyl)-4-methyl-oxazolidin- 2-one and 7.5 ml N-methylpyrrolidone was slowly added 5 g of 25% potassium-tot- amylate in toluene solution. The mixture was stirred, then cooled, and 4.5 g of 4-(4-iodo- butyl)-5-oxo-[l,4]diazepane-l-carboxylic acid tert-butyl ester was added. The mixture was stirred at ambient conditions for 6 hours. Water was added and the mixture stirred. The precipitated product is collected and dried to yield ca. 3.5 g of 4-{4-[5-(4-methanesulfonyl- phenyl)-4-methyl-2-oxo-oxazolidin-3-yl]-propyIJ-5-oxo-[l,4]diazepane-l-carboxylic acid tert-butyl ester. Step 2: 4-{4-[2-(4-methanesulfonyl-pheny0- 1-methyl-ethylamino] -butyl} -5-oxo- [1,4] diazepane- 1-carboxylic acid tert-butyl ester A mixture of 10 g 4-{4-[5-(4-methanesulfonyl-phenyl)-4-methyl-2-oxo-oxazolidin- 3-yl] -butyl} -5-oxo-[ 1,4] diazepane- 1 -carboxylic acid tert-butyl ester, 1 g of 20% palladium hydroxide on carbon, 10 ml water, and 90 ml isopropanol was stirred and heated to 50 to 60 °C. A solution of 3.5 g potassium formate in 5 ml water was slowly added. The mixture is stirred for 3 hours and is then cooled and filtered. The filtrate was stripped to yield ca. 9 g of 4-{4- [2-(4-methanesulfonyl-phenyl)-l-methyl-ethylamino] -butyl}-5-oxo- [1,4] diazepane- 1 -carboxylic acid tert-butyl ester. Step 3: 4-(4-{[(S -2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl1-propyl-amino}-butyl -5-oxo- [l,4]diazepane-l-carboxylic acid tert-butyl ester A mixture of sodium borohydride (0.55 g) and tetrahydrofuran (40 ml) was stirred and a mixture of acetic acid (2.62 g) and tetrohydrofuran (10 ml) slowly added with cooling to maintain the temperature below ambient. The mixture was stirred for several hours. A solution of the 4-{4-[2-(4-methanesulfonyl-phenyl)-l-methyl-ethylamino]-butyl}-5-oxo- [1,4] diazepane- 1-carboxylic acid tert-butyl ester (7.0 g) and propionaldehyde (0.85 g) in tetrahydrofuran (25 ml) was prepared. The solution was slowly added to the borohydride mixture with stirring. The mixture stirred several hours followed by slow addition of 25% sodium hydroxide solution (14 g).The upper organic layer was distilled under vacuum. The residue was dissolved in toluene and washed with water. The organic layer vacuum distilled to yield 7.5 g of 4-(4-{ [(S)-2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}- butyl)-5-oxo-[ 1,4] diazepane- 1-carboxylic acid tert-butyl ester as an oil. EXAMPLE 10 Composition for Oral Administration The ingredients are mixed and dispensed into capsules containing about 100 mg each; one capsule would approximate a total daily dosage. EXAMPLE 11 Composition for Oral Administration The ingredients are combined and granulated using a solvent such as methanol. The formulation is then dried and formed into tablets (containing about 20 mg of active compound) with an appropriate tablet machine. EXAMPLE 12 Composition for Oral Administration The ingredients are mixed to form a suspension for oral administration. EXAMPLE 13 Parenteral Formulation (IV) The active ingredient is dissolved in a portion of the water for injection. A sufficient quantity of sodium chloride is then added with stirring to make the solution isotonic. The solution is made up to weight with the remainder of the water for injection, filtered through a 0.2 micron membrane filter and packaged under sterile conditions. EXAMPLE 14 Suppository Formulation The ingredients are melted together and mixed on a steam bath, and poured into molds containing 2.5 g total weight. EXAMPLE 15 Topical Formulation All of the ingredients, except water, are combined and heated to about 60 °C with stirring. A sufficient quantity of water at about 60 °C is then added with vigorous stirring to emulsify the ingredients, and water then added q.s. about 100 g. EXAMPLE 16 Nasal Spray Formulations Several aqueous suspensions containing from about 0.025-0.5 percent active compound are prepared as nasal spray formulations. The formulations optionally contain inactive ingredients such as, for example, microcrystalline cellulose, sodium carboxy- methylcellulose, dextrose, and the like. Hydrochloric acid may be added to adjust pH. The nasal spray formulations ma be delivered via a nasal spray metered pump typically delivering about 50-100 microliters of formulation per actuation. A typical dosing schedule is 2-4 sprays every 4-12 hours. EXAMPLE 17 Radioligand binding studies The inhibitory activity of compounds of this invention in vitro was determined using a modification of the method described in Hegde, S.S. et al., Br. J. Pharmacol. 1997, 120, 1409-1418. Cell membranes from Chinese hamster ovary cells expressing the recombinant human muscarinic receptors (mj- s) were employed. The assays were conducted with the radioligand [ 3 H]N-methyl scopolamine(0.4 nM, specific activity 84 Ci • mmol "1 ) in a final volume of 0.25 mL Tris-Krebs buffer. Non-specific binding was defined with lμM atropine. Assays were performed using scintillation proximity assay technology. Competition- displacement curves were generated using 10 concentrations of test compounds and were analyzed by iterative curve fitting to a four parameter logistic equation. pICso values (-log of the IC50) were converted to pKi values using the Cheng- Prusoff equation. The muscarinic inhibitory activities (expressed as pKi values) of some exemplary compounds of this invention were: EXAMPLE 18 Oxotremorine/Pilocarpine-Induced Salivation (OIS/PIS) Model in Anesthetized Rats. Female Sprague-Dawley rats (Charles-River, 200-300 g) rats were anesthetized with urethane (1.5 g/kg, sc) and were tracheotomized. One femoral vein was cannulated for drug administration. After a one hour stabilization period, rats were pre-treated with methoctramine (only for OIS) to antagonize M 2 receptor mediated bradycardia. Each animal was dosed, intravenously, with a single dose of the vehicle or the reference compound. Ten minutes later, pre- eighed cotton pads were placed in the animals mouth following which they were dosed with vehicle or oxotremorine (0.1 mg/kg, iv)/pilocarpine (1 mg/kg, iv). Fresh cotton pads were placed at 5 minutes post-oxotremorine/pilocarpine and saliva collected for an additional 5 minutes. The cotton pads (5- and 10-minute period) were then re- weighed to determine the amount of saliva secreted during the 10- minute period. All oxotremorine/pilocarpine treated groups were compared using one-way analysis of variance. Pair-wise comparisons were made using Dunnett's test. The ranked data (non- parametric technique) or actual levels of the data (parametric technique) are applied in the analysis depending upon the results of the Bartlett's test, which tests homogeneity of variances. The vehicle/oxotremorine group and vehicle/pilocarpine was compared to the vehicle/vehicle group using Wilcox on rank- sum test. An estimate of the ID 50 for each compound with respect to the 10-minute overall secretion weight for each animal was obtained. The sigmoidal model is in the form of Resp = min + (max - min)/ (1 + (dose/LDso)** N) where ID 50 is the dose to achieve half the maximal response, N is the curvature parameter and max is the maximum response for the dose response curve. The minimum response (min) was fixed at 0 in the model. Compounds of this invention were active in this assay. EXAMPLE 19 Inhibition of Volume-Induced Contractions in Rats The muscarinic receptor inhibitory activity of compounds of this invention in vivo was determined in rats using a modification of the method described in Hegde, S.S. et al., Proceedings of the 26th Annual Meeting of the International Continence Society 1996 (August 27th -30th), Abstract 126. Female Sprague-Dawley rats were anesthetized with ur ethane and instrumented for intravenous administration of drugs and, in some cases, measurement of arterial pressure, heart rate and intra-bladder pressure. The effect of test compounds on volume-induced bladder contractions was determined in separate groups of animals. Volume- induced reflex bladder contractions were induced by filling the bladder with saline. The test compounds were administered intravenously in a cumulative manner at 10-minute intervals. Atropine (0.3 mg/kg, iv) was administered at the end of the study as a positive control. Compounds of this invention were active in this assay. EXAMPLE 20 Anti- muscarinic activity in anesthetized dogs The muscarinic receptor inhibitory activity of compounds of this invention in vivo was determined in dogs using a modification of the method described in Newgreen, D.T. et al., /. Urol. 1996, 155 (Suppl. 5), 1156. Female beagles (Marshall Farms, North Rose, NY) were fasted for 18 hours prior to the experiment; water was allowed ad libitum. On the day of the experiment, dogs were anesthetized and maintained on pentobarbital (36 mg/kg, iv initially, then 5-10 mg/kg, iv for maintenance). Intravenous fluids were also administered to the dog for the remainder of the experiment. The dogs were artificially ventilated, via an endotracheal tube, with an Harvard respirator (Model 613). Both femoral veins and one femoral artery was cannulated for drug administration and blood pressure measurement, respectively. Blood pressure was measured with a Gould transducer (Model P23XL) and recorded on a Gould recorder (Model 3400). A sublingual incision was made to expose the left mandibular duct, which was then cannulated for the collection of saliva into pre- weighed vials. The left salivary gland was exposed via a submandibular incision. The chorda-lingual nerve was isolated and had a bipolar electrode placed on it for stimulation. Test responses to chorda- lingual nerve stimulation were obtained to confirm proper electrode placement. After completion of surgery, physostigmine (180 μg/kg/hr, iv) (a cholinesterase inhibitor) was infused for the remainder of the experiment. Following a one hour stabilization period, two control chorda-lingual nerve stimulations were performed at 12 Hz, 10 V, 0.5 ms duration (Grass S48). The chorda-lingual nerve was stimulated for 20 seconds and 2 minutes, respectively, with a minimum of 10 minute interval between each set of stimulations. After two consistent control responses were obtained, the vehicle or the reference compound was dosed in a cumulative fashion, 3 minutes prior to each stimulation of the chorda-lingual nerve. Experiments in which consistent salivation responses could not be obtained were not included in the analysis. Atropine (1.0 mg/kg, iv) was given as a positive control at the end of the study. Mean arterial blood pressure was calculated as Diastolic arterial pressure + (Systolic • arterial pressure - Diastolic arterial pressure)/3. Heart rate was derived from the pressure pulse. Saliva was collected in pre- weighed vials and weighed after each collection to determine the volume of saliva secreted. Inhibition of salivary gland responses were expressed as a percent of the effect of atropine (1 mg/kg, iv). ED 5 o Estimation For % max inhibition salivation, parameter estimation was performed using a nonlinear mixed model. The method was implemented using PROC NLIN initially and PROC MIXED iteratively. This procedure assumed the following sigmoidal dose-response model: „ „ ,. Max - Min Response = Mm -I ^η^- I+IO "" " where response = % max inhibition bladder contraction at peak, x = log 10 dose of treatment and the 4 parameters were: log 10 ED 50 (μ), maximum and minimum response (Max and Min), and curvature (σ). The minimum was assumed 0%. This method assumed compound symmetry for the covariance structure. It was an iterative curve-fitting procedure that accounted for the dependence between multiple measurements from the same animal, and estimated the desired parameters and their confidence limits by adjusting its error calculations to account for within subject correlation. Baseline Comparisons To compare each dose to baseline control for every variable, a two-way ANOVA with main effects of subject and treatment was performed, followed by a pair t-test at each dose level. If the overall treatment effect was not significant (p-value > 0.05) in ANOVA, a Bonferroni adjustment for p-values was used for the p-value of pair t-test at each dose. Compounds of this invention were active in this assay. While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope of the invention. In addition, many modifications maybe made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective, spirit and scope of the present invention. All such modifications are intended to be within the scope of the claims appended hereto.

Claims: Claims 1. A compound having the general Formula I wherein R 1 , R 2 and R 3 are independently in each occurrence hydrogen, halogen, -OR, -SR, -NR'R", -SOR, -SO 2 R', -COOR, -OCOR, -OCONR'R", -OSO 2 R, -OSO 2 NR'R"; -NR'SO 2 R", -NRCOR", -SO 2 NR'R", -SO 2 (CH 2 ) 1-3 CONR'R", -CONR'R", cyano, halogenalkyl or nitro; or R 1 and R 2 if adjacent, taken together with the carbons to which they are attached may also form a 5- to 7- membered aromatic, saturated or unsaturated ring, optionally incorporating one or two ring heteroatoms chosen from N, S(O)o -2 , or O, and optionally substituted with (Cι -6 )-alkyl, halogen, cyano or lower alkoxy; R' and R" are independently in each occurrence hydrogen, (C 1-6 )-alkyl, substituted ( ^-alkyl, (Co- 3 )-alkyl-alkoxy, aryl, heterocyclyl, heteroaryl, aryl- ( C 1 - 3 ) -alkyl, heteroaryl- ( Q. 3 ) -alkyl, heterocyclyl- ( C 1-3 ) -alkyl, cycloalkylalkyl, cycloalkyl, or R and R" together with the nitrogen they are attached may also form a 5- to 7- membered ring, optionally incorporating one additional ring heteroatom chosen from N, O or S(O) 0-2 ; R 4 is independently in each occurrence R 5 is independently in each occurrence (C 1-6 )-alkyl, (C 1-6 ) -alkenyl, (C 1-6 )-alkynyl or cycloalkyl; one of X, Y or Z is independently -S-, -O-, -CH 2 - or >N-R 6 , the others are -CH 2 -; R 6 is hydrogen, halogenalkyl, aryl-(Cι -6 )-alkyl, heteroaryl-(C 1-6 )-alkyl, -(Cι -6 )-CR'R * R, -COOR', -SO 2 R, -C(O)R, -SO 2 -(CH 2 ) 0-3 -NR'R", -CONR'R", -C(O)OCH 2 OC(O)R, -C(O)O-CH 2 -S-C(O)R' or -PO(OR') 2 , wherein R' and R" are as defined above; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; or prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. 2. The compound of claim 1, wherein R 1 , R 2 and R 3 are independently in each occurrence hydrogen, halogen, (C 1-6 )-alkyl, -OR, -SR, -NR'R", -SOR, -SO 2 R, -COOR', -OCOR, -OCONR'R", -OSO 2 R, -OSO 2 NR'R"; -NR'SO 2 R", -NR'COR", -SO 2 NR'R", - SO 2 (CH 2 )ι -3 CONR'R", -CONR'R", cyano, halogenalkyl or nitro; or R 1 and R 2 if adjacent, taken together with the carbons to which they are attached may also form a 5- to 7- membered aromatic, saturated or unsaturated ring, optionally incorporating one or two ring heteroatoms chosen from N, S(O) 0-2 , or O, and optionally substituted with (C 1-6 )-alkyl, halogen, cyano or lower alkoxy; R and R" are independently in each occurrence hydrogen, (C 1-6 )-alkyl, substituted (C 1-6 )-alkyl, aryl, heterocyclyl, heteroaryl, aryl-(C 1-3 )-alkyl, heteroaryl-(C 1-3 )-alkyl, heterocyclyl-(Cι -3 )-alkyl, cycloalkylalkyl, cycloalkyl, or R' and R" together with the nitrogen they are attached may also form a 5- to 7- membered ring, optionally incorporating one additional ring heteroatom chosen from N, O or S(O) 0-2 ; R 4 is independently in each occurrence (C 1-6 )-alkyl; R 5 is independently in each occurrence ( ^-alkyl, ( -6 )-alkenyl, (C 1-6 )- alkynyl or cycloalkyl; one of X, Y or Z is independently -S-, -O-, -CH 2 - or >N-R 6 , the others are -CH 2 -; R 6 is hydrogen, (C 1-6 )-alkyl, halogenalkyl, aryl-(C 1-6 )-alkyl, heteroaryl-(C 1-6 )-alkyl, -(Cι -6 )-CR'R'R, -COOR, -SO 2 R', -C(O)R', -SO 2 -(CH 2 )o- 3 -NR'R", -CONR'R", or -PO(OR') 2 , wherein R and R" are as defined above; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; or prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. 3. The compound of claim 1 or 2, wherein n is 3. 4. The compound of claim 1 or 2, wherein R 4 is methyl. 5. The compound of claim 4, wherein m is 0. 6. The compound of claim 4, wherein m is 1. 7. The compound of claim 6, wherein Y is >N-R 6 . 8. The compound of claim 7, which compound is selected from the group consisting of l-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-piperazin-2-one; l-(4-{[(S)-2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)-4- methyl-piperazin-2-one; or N-methyl-4-((S)-2-{[4-(2-oxo-piperazin-l-yl)-butyl]-propyl-amino}-propyl)- benzenesulfonamide. 9. The compound of claims 3 or 4, wherein m is 2. 10. The compound of claim 9, which compound is selected from the group consisting of l-(4-{ethyl-[2-(4-methanesulfonylphenyl)-l-methylethyl] amino }butyl)-azepan-2-one; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-[l,4]oxazepan-3- one; or 1,1,1-trifluoromethanesulfonic acid 4-(2-{ethyl-[4-(2-oxo-azepan-l-yl)butyl] - amino Jpropyl) -phenyl ester. 11. The compound of claim 9, wherein one of X, Y or Z is >NR 6 and the others are -CH 2 -. 12. The compound of claim 11, wherein X is >NR 6 . 13. The compound of claim 11, wherein Y is >NR . 14. The compound of claim 13, which compound is selected from the group consisting of l-(4-{ [(S)-2-(-4-methanesulfonyl-phenyl)-l-methylethyl]propylamino}butyl)- [ 1 ,4] diazepan-2-one; l-(4-{ethyl- [ (S)-l-methyl-2-(4-trifluoromethyl-phenyl)-ethyl] -amino}-butyl)- [ 1,4] - diazepan-2-one; or l-(4-{[(S)-2-(4-methanesulfonyl-phenyl)-l-methyl-ethyl]-propyl-amino}-butyl)-4- methyl- [1,4] diazepan-2-one. 15. The compound of claim 11 , wherein Z is >NR 6 . 16. The compound of claim 15, which compound is selected from the group consisting of 4-(4-{allyl- [2-(4-methanesulfonylphenyl)- 1-methylethyl] amino Jbutyl) - [ 1,4] diazepan-5- one; 4- (4- { [2- (4-tot-butylphenyl)- 1 -methylethyl] propylaminojbutyl)- [ 1 ,4] diazepan-5-one; 4-(4-{[2-(4-methanesulfonylphenyl)-l-methylethyl]propylamino}butyl)-5-oxo- [1,4] diazepane- 1-carboxylic acid ethyl ester; 4-(4-{[(S)-2-(4-methanesulfonylphenyl)-l-methyl-ethyl]propylaminoJbutyl)- [l,4]diazepan-5-one; propane-2-sulfonic acid 4-((S)-2-{[4-(7-oxo-[l,4]-diazepin-l-yl)-butyl]-propyl-amino}- propyl) -phenyl ester; or 4-(4-{[(S)-2-(2,3-dihydro-l,4-benzodioxin-6-yl)-l-methyl-ethyl]-propyl-aminoJ-butyl)- [1,4] -diazepan-5-one. 17. The compound of claims 3 or 4, wherein one of X, Y or Z is -O- or -S- and the others are -CH 2 -. 18. A pharmaceutical composition comprising a therapeutically effective amount of one or more compounds of any of claims 1 to 17 in admixture with a pharmaceutically acceptable carrier. 19. The pharmaceutical composition of claim 18 wherein the compound is suitable for administration to a subject having a disease state which is alleviated by treatment with a M2/M3 muscarinic receptor antagonist. 20. A process for preparing a compound as claimed in claim 1 which process comprises a) reacting a compound having a general formula II II with a compound of general formula III to provide a compound of general formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 , m, n, X, Y, and Z are as defined in claim 1; or b) (i) reacting an aryl metal compound having a general formula IV IV in which M is a metal or a magnesium halide, with a compound of formula V V in which R is alkyl, aryl or arylalkyl, and R a and R b are alkyl or alkoxy, or R a and R together with the nitrogen to which they are attached form a ring, to afford a compound of formula VI VI and (ii) reducing the compound of formula VI followed by cyclization, and treating with a compound of formula R L, wherein L is a leaving group, to afford a compound of formula VII and (iii) reducing the compound of formula VII, and treating with a compound of general formula II II to provide a compound of general formula I wherein R , 1 , π R2 , π R3 , r R.4 , - Rr,5 , m, n, X, Y, and Z are as defined in claim 1; or c) (i) reducing a compound of formula VI VI followed by cyclization and (ii) treating a compound of formula VI with a compound of formula VIII VIII wherein L is a leaving group, and (iii) reducing the product to afford a compound of formula IX IX and (iv) alkylating a compound of formula IX with an appropriate aldehyde or with a compound of Formula R 5 L, wherein L is a leaving group, to provide a compound of formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, Z, m and n are as described in claim 1. 21. A compound according to any one of claims 1 to 17 whenever prepared by a process as claimed in claim 20 or by an equivalent method. 22. The use of one or more compounds according to any one of claims 1 to 17 for the treatment or prevention of a disease state. 23. The use of one or more compounds according to any one of claims 1 to 17 for the manufacture of medicaments for the treatment or prevention of a disease state, which is alleviated by treatment with a M2/M3 muscarinic antagonist. 24. The use according to claim 23, wherein the disease state is associated with smooth muscle disorders comprising diseases of the genitourinary or gastrointestinal tract, or of respiratory states. 25. The invention as hereinbefore described. ***

Inventors: DVORAK CHARLES ALOIS, FISHER LAWRENCE EMERSON, GREEN KEENA LYNN, HARRIS RALPH NEW III, MAAG HANS, PRINCE ANTHONY, REPKE DAVID BRUCE, STABLER RUSSELL STEPHEN, DVORAK, CHARLES, ALOIS, FISHER, LAWRENCE, EMERSON, GREEN, KEENA, LYNN, HARRIS, RALPH, NEW, III, MAAG, HANS, PRINCE, ANTHONY, REPKE, DAVID, BRUCE, STABLER, RUSSELL, STEPHEN
Applicants: HOFFMANN LA ROCHE, F. HOFFMANN-LA ROCHE AG
Application year: 2001
Main classification: C07D241
IPC codes: A61K31, A61P1, A61P3, A61P9, A61P11, A61P13, A61P15, A61P21, A61P43, C07D207, C07D211, C07D223, C07D225, C07D239, C07D241, C07D243, C07D265, C07D267, C07D279, C07D401, C07D403, C07D405, C07D409, C07D411, C07D413, C07D417, C07D487, C07D513