HYDROXYPHENYL-PIPERIDIN-4-YLIDENE-METHYL-BENZAMIDE DERIVATIVES FOR THE TREATEMENT OF PAIN

Abstract: Compounds of general formula (I) where R<1> is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, triazolyl and thiazolyl; where each R<1> phenyl ring and R<1> heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

Description: HYDROXYPHENYL-PIPERIDIN-4-YLIDENE-METHYL-BENZAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN Field of the invention The present invention is directed to novel compounds, to a process for their preparation, their use and pharmaceutical compositions comprising the novel compounds. The novel compounds are useful in therapy, and in particular for the treatment of pain. Background and prior art The δ receptor has been identified as having a role in many bodily functions such as circulatory and pain systems. Ligands for the δ receptor may therefore find potential use as analgesics, and/or as antihypertensive agents. Ligands for the δ receptor have also been shown to possess immunomodulatory activities. The identification of at least three different populations of opioid receptors (μ, δ and K) is now well established and all three are apparent in both central and peripheral nervous systems of many species including man. Analgesia has been observed in various animal models when one or more of these receptors has been activated. With few exceptions, currently available selective opioid δ ligands are peptidic in nature and are unsuitable for administration by systemic routes. One example of a non-peptidic δ-agonist is SNC80 (Bilsky E.J. et al, Journal of Pharmacology and Experimental Therapeutics, 273(1), pp. 359-366 (1995)). There is however still a need for selective δ-agonists having not only improved selectivity, but also an improved side-effect profile. Thus, the problem underlying the present invention was to find new analgesics having improved analgesic effects, but also with an improved side-effect profile over current μ agonists, as well as having improved systemic efficacy. Analgesics that have been identified and are existing in the pnor art have many disadvantages in that they suffer from poor pharmacokinetics and are not analgesic when administered by systemic routes. Also, it has been documented that preferred δ agonist compounds, descnbed within the pnor art, show significant convulsive effects when administered systemically. We have now found that certain compounds not specifically disclosed by, but included within the scope of WO 98/28275, exhibit surpnsingly improved δ-agonist properties and in vivo potency Outline of the invention The novel compounds according to the present invention are defined by the formula I wherein R is selected from any one of (I) phenyl; (n) pyπdinyl (in) thienyl (IV) furanyl (v) lmidazolyl (vi) tπazolyl (vn) thiazolyl where each R phenyl πng and R heteroaromatic πng may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched Ci-Cβ alkyl, NO2, CF3, -Cβ alkoxy, chloro, fluoro, bromo, and lodo The substitutions on the phenyl πng and on the heteroaromatic πng may take place in any position on said πng systems A prefeπed embodiment of the piesent invention is a compound according to figure I wwhheerreeiinn RR iiss aass ddeeffiinneedd aabboovvee aanndd eeaacchh RR pphheennyyll nπng and R heteroaromatic πng may independently be further substituted by a methyl group A more prefeπed embodiment of the present invention is a compound according to figure I wherein R is pyridinyl, thienyl or furanyl. Within the scope of the invention are also salts and enantiomers of the compounds of the formula I, including salts of enantiomers. When the phenyl ring and the heteroaromatic ring(s) are substituted, the preferred substituents are selected from anyone of CF3, methyl, iodo, bromo, fluoro and chloro. Reaction step g in Scheme 1, vide infra, is performed by reacting an intermediate compound of the general formula II wherein PG is a urethane or benzyl-like protecting group, such as Boc, with 3- hydroxyphenyl boronic acid, using a palladium catalyst, e.g. Pd(PPh3)4, in the presence of a base, e.g. Na2CO3, to give the compounds of general formula III, which is thereafter deprotected, under standard conditions and alkylated under reductive ccoonnddiittiioonnss wwiitthh aa ι compound of the general formula R -CHO to give compounds of the general formula I Suitable palladium catalysts include, but is not limited to, PdCl2 (with a phosphme), Pd(OAc) 2 (with a phosphme), Pd(dba) 2 , PdCl 2 (dppf) CH 2 C1 2 , Pd(PPh 3 ) 4 , Pd C Suitable bases include, but is not limited to, tπethylamine, sodium and potassium carbonate Suitable reducing agents to be used includes, but is not limited to, sodium cyanoborohydπde and sodium tπacetoxyborohydπde. The novel compounds of the present invention are useful m therapy, especially for the treatment of vaπous pain conditions such as chronic pain, neuropathic pain, acute pain, cancer pain, pain caused by rheumatoid arthπtis, migraine, visceral pain etc. This list should however not be inteφreted as exhaustive Compounds of the invention are useful as immunomodulators, especially for autoimmune diseases, such as arthπtis, for skm grafts, organ transplants and similar surgical needs, for collagen diseases, vaπous allergies, for use as anti-tumour agents and anti viral agents Compounds of the invention are useful in disease states where degeneration or dysfunction of opioid receptors is present or implicated m that paradigm This may involve the use of isotopically labelled versions of the compounds of the invention in diagnostic techniques and imaging applications such as positron emission tomography (PET) Compounds of the invention are useful for the treatment of diarrhoea, depression, anxiety, uπnary incontinence, vaπous mental illnesses, cough, lung oedema, vaπous gastro- intestinal disorders, spinal injury and drug addiction, including the treatment of alcohol, nicotine, opioid and other drug abuse and for disorders of the sympathetic nervous system for example hypertension Compounds of the invention are useful as an analgesic agent for use duπng general anaesthesia and monitored anaesthesia care. Combinations of agents with different properties are often used to achieve a balance of effects needed to maintain the anaesthetic state (eg amnesia, analgesia, muscle relaxation and sedation) Included in this combination are inhaled anaesthetics, hypnotics, anxiolytics, neuromuscular blockers and opioids Also within the scope of the invention is the use of any of the compounds according to the formula I above, for the manufacture of a medicament for the treatment of any of the conditions discussed above A further aspect of the invention is a method for the treatment of a subject suffeπng from any of the conditions discussed above, whereby an effective amount of a compound according to the formula I above, is administered to a patient m need of such treatment A further aspect of the present invention is intermediates of the general formula II, wherein PG is a urethane or benzyl-like protecting group, such as Boc, Methods of preparation The compounds according to the present invention may be prepared by following the known procedures described in e.g. "Advanced Organic Chemistry" third edition, by Jerry March, John Wiley and Sons Inc.; New York (1985): Step (a): p848; Step (b): p848; Step (c): p657; Step (d): p875; Step (e): p371-373; Step (f): p364-366; Step (g): N. Miyaura and A. Suzuki, Chem. Rev., 95, 2457-2483(1995); Step (h): "Protective Groups in Organic synthesis" p 327-329, by Theodora W. Greene and Peter G.M. Wuts, Second Edition, John Wiley and Sons Inc.; New York (1991). These references are hereby incorporated in full. EXAMPLES The invention will now be described in more detail by the following Examples, which are not to be construed as limiting the invention. Example 1 Preparation of N-N-diethyl-4-(3-hvdroxy-phenyl-piperidin-4-ylidene-methvI)- benzamide (compound 7) (i) Preparation of 4-(4-methoxycarbonyl-benzylidene)-piperidine-l-carboxylic acid fert-butyl ester (compound 3) A mixture of compound 1 (11.2 g, 49 mmol) and tπmethyl phosphite (25 mL) was refluxed under N 2 for 5 hrs. Excess tπmethyl phosphite was removed by co-distillation with toluene to give compound 2 in quantitative yield: Η NMR (CDC1 3 ) δ 3.20 (d, 2H, J=22 Hz), 3.68 (d, 3H 10.8 Hz), 3.78 (d, 3H, 11.2 Hz), 3.91 (s, 3H), 7 38 (m, 2H), 8.00 (d, 2H, J=8 Hz) (ii) To a solution of the above product (compound 2) in dry THF (200 mL) was added dropwise lithium diisopropylarmde (32.7 mL 1.5 M in hexanes, 49 mmol) at -78 °C. The reaction mixture was then allowed to warm to room temperature pnor to addition of N- tert-butoxycarbonyl-4-pιpeπdone (9.76 g, 49 mmol in 100 mL dry THF). After 12 hrs, the reaction mixture was quenched with water (300 mL) and extracted with ethyl acetate (3 x 300 mL). The combined organic phases were dried over MgS0 4 and evaporated to give a crude product, which was purified by flash to provide compound 3 as a white solid (5.64 g, 35%): IR (NaCl) 3424, 2974, 2855, 1718, 1688, 1606, 1427, 1362, 1276 cm '; Η NMR (CDC1 3 ) δ 1.44 (s, 1H), 2.31 (t, J=5.5 Hz, 2H), 2.42 (t, J=5.5 Hz, 2H), 3.37 (t, J=5.5 Hz, 2H), 3.48 (t, J=5.5 Hz, 2H), 3.87(s, 3H), 6.33 (s, 1H), 7.20 (d J=6.7 Hz, 2H), 7.94 (d, J =6.7 Hz, 2H); 13 C NMR (CDCI 3 ) δ 28.3, 29.2, 36.19, 51.9, 123 7, 127.8, 128.7, 129.4, 140.5, 142.1, 154.6, 166.8. (iii) Preparation of 4-bromo-4-rbromo-(4-methoxycarbonyl-phenyl)-methyll- piperidine-1-carboxylic acid tert-butyl ester (compound 4) To a mixture of compound 3 (5.2 g, 16 mmol) and K 2 C0 3 (1.0 g) in dry dichloromethane 5 (200 mL) was added a solution of bromine (2.9 g, 18 mmol) in 30 mL CH 2 C1 2 at 0 °C. after 1.5 hrs at room temperature, the solution after filtration of K 2 C0 3 was condensed. The residue was then dissolved in ethyl acetate (200 mL), washed with water (200 mL), 0.5 M HCl (200 mL) and bπne (200 mL), and dπed over MgS0 Removal of solvents provided a crude product, which was recrystalhzed from methanol to give compound 4 as a white o solid (6.07 g, 78%): IR (NaCl) 3425, 2969, 1725, 1669, 1426, 1365, 1279, 1243 cm ', Η NMR (CDC1 3 ) δ 1.28 (s, 9H), 1 75 (m, 2H), 1.90 (m, 2H), 2.1 (m, 4H), 3.08 (br, 4H), 3.90 (s, 3H), 4.08 (br, 4H), 5.14 (s, 1H), 7 57 (d, J=8.4 Hz, 2H) 7.98 (d, J=8.4 Hz, 2H); 13 C NMR (CDCI 3 ) δ 28.3, 36.6, 38.3, 40.3, 52.1, 63.2, 72.9, 129.0, 130.3, 130.4, 141.9, 154.4, 166.3. 5 (iv) Preparation of 4-rbromo-(4-caboxy-phenvI)-methylene]-piperidine-l-carboxylic acid tert-butyl ester (compound 5) A solution of compound 4 (5.4 g 11 mmol) in methanol (300 mL) and 2.0 M NaOH (100 mL) was heated at 40 °C for 3 hrs. The solid was collected by filtration, and dπed o overnight under vacuum. The dry salt was dissolved in 40% acetomtπle/water, and was adjusted to pH 2 using concentrated HCl. The desired product compound 5 (3.8 g, 87%) was isolated as a white powder by filtration: 1H NMR (CDC1 3 ) δ 1.45 (s, 9H), 2.22 (dd, J=5.5 Hz, 6.1 Hz, 2H), 2.64 (dd, J=5 5 Hz. 6.1 Hz, 2H), 3.34 (dd, J=5.5 Hz, 6.1 Hz, 2H), 3.54 (dd, J=5.5 Hz, 6.1 Hz, 2H), 7.35 (d, J=6.7 Hz, 2H), 8.08 (d, J=6.7 Hz, 2H); 13 C NMR 5 (CDCI 3 ) 6 28.3, 31.5, 34.2, 440, 115 3, 128 7, 129 4, 130.2, 137.7, 145.2, 154.6, 170.3, (v) Preparation of 4-rbromo-(4-diethylcarbamoyl-phenyl)-methylenel-piperidine-l- carboxylic acid tert-butyl ester (compound 6) To a solution of compound 5 (1.0 g, 2.5 mmol) in dry dichloromethane (10 mL) at - 20 °C was added lsobutylchloroformate (450 mg, 3.3 mmol) After 20 min at -20 °C diethylamine (4 mL) was added and the reaction was allowed to warm to room temperature. After 1.5 hrs the solvents were evaporated and the residue was partitioned between ethyl acetate and 5 water. The organic phase was washed with brine and dπed over MgS0 . Removal of solvents provided a crude product, which was puπfied by flash chromatography to give compound 6 as white needles (800 mg, 73%): IR (NaCl) 3051, 2975, 1694, 1633, 1416, 1281, 1168, 1115 cm '; 1 H NMR (CDCl 3 ) δ 1.13 (br, 3H), 1.22 (br, 3H), 1.44 (s, 9H), 2.22 (t, J=5.5 Hz, 2H), 2.62 (t, J=5.5 Hz, 2H), 3.33 (m, 4H). 3.55 (m, 2H), 7.31 (d, J=8.0 Hz, 0 2H), 7.36 (d, J=8.0 Hz, 2H); π C NMR (CDC ) δ 12 71, 14 13, 28.3, 31.5, 34.2, 39.1, 43.2, 79.7, 115.9, 126.3, 129.3, 136.8, 137.1, 140.6, 154 6, 170.5. (vi) Preparation of 3-hydroxylphenyl boronic acid 3-Bromophenol (8.65 g, 50 mmol) in dry THF (150 mL) was treated with sodium hydπde s (60%, 2.4 g, 60 mmol) at r.t. After 1 h, sec-butyllithium (1.3 M, 50 mL, 65 mmoL) was added dropwise to the reaction solution at -78 °C. The reaction mixture was then allowed to stir at the same temperature for 30 min pnor to addition of tπmethyl borate (15 mL). After warming up to r.t. for 2 hrs, the reaction mixture was quenched with water (50 mL), and extracted with dichloromethane (2 x 100 mL). The combined organic phases were o dried over MgSO 4 and evaporated to give the title compound as a white solid (4.0 g, 58 %), which was used in the Suzuki coupling reactions without further puπfication. (vii) Preparation of N.N-diethyl-4-(3-hvdroxylphenyl-piperidin-4-ylidene-methyl)- benzamide (compound 7) A mixture of compound 6 (451 mg, 1.0 mmol), 3-hydroxylphenyl boronic acid (230 mg, 1.7 mmol), 2M Na 2 CU3 (2.5 mL), and tetrakis(triphenyl phosphine) palladium(O) (20 mg) in toluene (degassed, 5 mL) and ethanol (degassed, 5 mL) was refluxed at 90 °C for 4 hrs under N 2 . The reaction mixture was then cooled down to r.t., and extracted with ethyl acetate (2 x 100 mL). The combined organic phases were dried over MgSO 4 and evaporated to give a crude product. The above product was treated with 4.0 M HCl in dioxane at 50 °C for 2 h. After evaporation, the residue was dissolved in 1 M HCl (100 mL) and impurities were extracted with diethyl ether (3 x 100 mL). The aqueous phase was basified with NELOH and extracted with dichloromethane (3 x 100 mL). The combined organic phases were washed with brine, dried over MgSO and evaporated to give the title compound 7 (305 mg, 88 %): Η-NMR (400 MHz, CDCI3) δ 1.12 (3 H, br m, CHjCH ), 1.23 (3 H, br m, CH^CH,- ), 2.33 (4 H, m, piperidine CH-), 2.89 (4 H, m, piperidine CH-), 3.29 (3 H, br m, NH & CH 3 CH 2 N-), 3.53 (2 H, br m, CH 3 CH 2 N-), 4.71 (1H, s, OH), 6.57 (2 H, m, ArH), 6.65 (1 H, m, ArH), 7.09 (1 H, m, ArH), 7.12 (2 H, d, / = 8.0 Hz, ArH), 7.28 (2 H, d, J = 8.0 Hz, ArH); Its HCl salt: m.p. >430 °C (Dec); IR (NaCl) 2975, 1598, 1442, 1293 cm " 1 . Example 2 Preparation of N,N-diethyl-4-(3-hvdroxylphenyl-N-benzyl-piperidin-4-ylidene- methvD-benzamide (compound 9) (i) Preparation of N,N-diethyl-4-(bromo-N-benzyl-piperidin-4-vIidene-methv-)- benzamide (compound 8) Compound 6 prepared in Example l(v) above (2.26 g, 5.0 mmoL), was treated with TFA (25 mL) in dichloromethane (25 mL) at room temperature. After 2 h, the reaction mixture was condensed to give a residue, which was dissolved in acetonitrile (20 mL), and was reacted with benzyl bromide ( 5.0 mmol) at r.t. for 2 h. The reaction mixture was condensed, and then dissolved in ethyl acetate (100 mL). The organic solution were washed with IN NH 4 OH and brine, dried over MgS0 . Removal of solvents provided a crude product, which was purified by flash chromatography to give compound 8 as an oil (1.0 g, 45%): IR (NaCl) 2971, 1630, 1427, 1287, 1094 cm "1 ; Η NMR (CDC1 3 ) δ 1.13 (br, 3H), 1.23 (br, 3H), 2.28 (m, 2H), 2.37 (m, 2H), 2.55 (m, 2H), 2.69 (m, 2H), 3.27 (m, 2H), 3.53 (br, 4H), 7.31 (m, 4H). (ii) Preparation of N-N-diethv--4-(3-hvdroxylphenyl-N-benzyl-piperidin-4-ylidene- methvD-benzamide (compound 9) A mixture of compound 8 prepared in step (i) above (600 mg, 1.36 mmol), 3- hydroxylphenyl boronic acid (414 mg, 3.0 mmol), 2M Na 2 C0 3 (3.0 mL), and tetrakis(triphenyl phosphine) palladium(O) (20 mg) in toluene (degassed, 5 mL) and ethanol (degassed, 5 mL) was refluxed at 90 °C for 2 hrs under N 2 . The reaction mixture was then cooled down to r.t., and extracted with ethyl acetate (2 x 100 mL). The combined organic phases were washed with brine, dried over MgS0 4 . Removal of solvents provided a crude product, which was purified by flash chromatography to give the desired title compound 9 (482 mg, 78 %): IR (NaCl) 3350, 2974, 1606, 1442, 1291 cm " '; Η-NMR (400 MHz, CDCI3) δ 1.11 (3 H, br m, CH 3 CH 2 -), 1-24 (3 H, br m, CH 3 CH 2 -), 2.36 (4 H, m, piperidine CH-), 2.46 (4 H, m, piperidine CH-), 3.26 (2 H, br m, CHs N-), 3.53 (4 H, br m, PhCI N & CH 3 CH 2 N-), 6.53 (1 H, m, ArH), 6.57 (1 H, m, ArH), 6.63 (1 H, m, ArH), 7.07 (3 H, m, ArH), 7.25 (7 H, m, ArH).. Examples 3-11 Compounds 10-18 of Examples 3-11, were prepared by following the synthetic procedures of Scheme 2 below. Scheme 2: 1(3) 12 Scheme 2: 2(3. Scheme 2: 3(3) 18 Example 3 Preparation of N,N-diethyl-4-{(3-hvdroxyphenyl)ri-(2-thienylmethyl)-4- piperidinylidenelmethyllbenzamide (compound 10) 5 To a room temperature solution of secondary amine (600mg; 1.65mmol) in methanol (15ml) was added thiophene-2-carboxaldehyde (153.8ul; 1.65mmol), followed by acetic acid (1ml). The mixture was stiπed for two hours then sodium cyanoborohydride (31 lmg; 4.95mmol) was added. The reaction mixture was stirred overnight, then water was added and the mixture extracted with methylene chloride. Combined methylene chloride extracts o were dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase purification. (M+l) calculated: 461.64, (M+l) observed: 461.06 s Anal.: calculated for (C 28 H 32 Ν 2 0 2 S X 1.60 C 2 H0 2 F 3 X 0.20 H 2 O): C:57.95%; H:5.30%; N:4.33%; found: C:57.90%; H:5.34%; N:4.36% 'HNMR (CD 3 OD): 7.54 (dd, IH, J=5.2,1.6Hz), 7.25 (d, 2H, J=8Hz), 7.23-7.24 (m, IH), 7.15 (d, 2H, J=8Hz), 7.03-7.08 (m, 2H), 6.58-6.62 (dd, IH, J=8.0, 2.8Hz), 6.52-6.55 (dd, o IH, J=7.6, 1.6Hz)), 6.44-6.46 (dd, IH, J=2.8, 1.6Hz), 4.50 (s, 2H), 3.40-3.50 (m, 4H), 3.15-3.25 (m, 2H), 2.95-3.05 (m, 2H), 2.60-2.80 (m, 2H), 2.35-2.45 (m, 2H), 1.10-1.15 (m, 3H), 1.00-1.05 (m, 3H) Example 4 Preparation of N,N-diethyl-4-{(3-hvdroxyphenvI)ri-(3-thienylmethyl)-4- piperidinylidenelmethyllbenzamide (compound 11) 5 To a room temperature solution of secondary amine (500mg; 1.37mmol) in methanol (13ml) was added thiophene-3-carboxaldehyde (144.0ul; 1.65mmol), followed by acetic acid (1ml). The mixture was stirred for three hours then sodium cyanoborohydride (258mg; 4.1 lmmol) was added. The reaction mixture was stirred overnight, then water was added and the mixture extracted with methylene chloπde. The aqueous phase was neutralized 0 with potassium bicarbonate and was extracted again with methylene chloπde. Combined methylene chloride extracts were dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase purification. (M+l) calculated: 461.64, (M+l) observed: 461.07 5 Anal.: calculated for (C 28 H 32 Ν 2 O 2 S X 1.10 C 2 HO 2 F 3 X 0.50 H 2 0): C:60.96%; H:5.78%; N:4.71%; found: C:60.97%; H:5.78%; N:4.65% 'HNMR (CD 3 OD): 7.59 (dd, IH, J=3.2, 1.6Hz), 7.49 (dd, IH, J=5.2, 3.2Hz), 7.26(d, 2H, o J=8.0Hz), 7.16 (d, 2H, J=8.0Hz), 7.15 (m, IH), 7.07 (dd, IH, J=8.0, 7.2Hz), 6.61 (dd, IH, J=8.0, 2.0Hz), 6.55 (d, IH, J=7.2Hz), 6.47 (dd, IH, J=2.0, 1.6Hz), 4.29 (s, 2H), 3.40-3.50 (m, 4H), 3.15-3.25 (m, 2H), 2.95-3.05 (m, 2H), 2.60-2.80 (m, 2H), 2.35-2.45 (m, 2H), 1.15-1.20 (t, 3H, J=6.4Hz), 1.00-1.05 (t, 3H, J=6.4Hz) Example 5 Preparation of N,N-diethyl-4-rri-(2-furylmethyl)-4-piperidinylidene1(3- hvdroxyphenvDmethvilbenzamide (compound 12) To a room temperature solution of secondary amme (500mg; 1.37mmol) in methanol 5 (13ml) was added 2-furaldehyde (136. Oμl; 1.65mmol), followed by acetic acid (1ml). The mixture was stiπed for three hours then sodium cyanoborohydπde (258mg; 4.1 lmmol) was added. The reaction mixture was stirred overnight, then water was added and the mixture extracted with methylene chloπde. The aqueous phase was neutralized with potassium bicarbonate and was extracted again with methylene chloπde. Combined methylene 0 chloπde extracts were dπed over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase puπfication. (M+l) calculated: 445.57, (M+l) observed: 445.13 s Anal.: calculated for (C 28 H 32 Ν 2 O 3 X 1.30 C 2 H0 2 F 3 X 0.10 H 2 0): C:61.81%; H:5.68%, N:4.71%; found: C:61.88%; H:5.74%; N:4.73% 'HNMR (CD 3 OD): 7.58 (d, IH, J=1.6Hz), 7.26 (d, 2H, J=8.0Hz), 7.16 (d, 2H, J=8.0Hz), 7.07 (t, IH, J=8.0Hz), 6.62-6.64 (m, IH), 6.60-6.61. (m, IH), 6.53-6.55 (m, IH), 6.46-6.47 o (m, IH), 6.43-6.45 (m, IH), 4.34 (s, 2H), 3.40-3.50 (m, 4H), 3.15-3.25 (m, 2H), 2.95-3.05 (m, 2H), 2.55-2.80 (m, 2H), 2.35-2.50 (m, 2H), 1.15-1.20 (t, 3H, J=6.4Hz), 1.00-1.05 (t, 3H, J=6.4Hz) Example 6 Preparation of N,N-diethv--4-[Tl-(3-furylmethyl)-4-piperidinylidenel(3- hvdroxyphenyl)methyl " lbenzamide (compound 13) To a room temperature solution of secondary amine (300mg, 0.82mmol) in methanol (8ml) was added 3-furaldehyde (214.0μl; 2.47mmol), followed by acetic acid (0.5ml) and sodium cyanoborohydπde (155mg; 2.47mmol). The reaction mixture was stirred overnight, quenched with sodium bicarbonate and extracted with methylene chloπde. Combined methylene chloπde extracts were dπed over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase puπfication. (M+l) calculated: 445.57, (M+l) observed: 445 15 Anal.: calculated for (C 28 H 32 Ν 2 0 3 X 0.50 C 2 H0 2 F 3 X 0.10 H 2 0): C:69.20%; H:6.55%; N:5.56%; found: C:69.14%; H:6.57%; N:5.28% 1 HNMR (CD 3 OD): 7.75 (s, IH), 7.61-7.62 (m, IH), 7.33 (d, 2H, J=8.0Hz), 7.23 (d, 2H, J=8.0Hz), 7.13 (dd, IH, J=8.4, 8.0Hz), 6.66-6.69 (m, IH), 6.57-6.63 (m, 2H), 6.51-6.53 (m, IH), 4.22 (s, 2H), 3.45-3.55 (m, 4H), 3.25-3.30 (m, 2H), 2.95-3.10 (m, 2H), 2.65-2.85 (m, 2H), 2.40-2.55 (m, 2H), 1.15-1.25 (m, 3H), 1.05-1.15 (m, 3H) Example 7 Preparation of N,N-diethyl-4-{(3-hvdroxyphenyl)ri-(2-pyridinylmethyl)-4- piperidinylidenelmethylrbenzamide (compound 14) To a room temperature solution of secondary amine (384.3mg; 1.05mmol) in methanol (10ml) was added 2-pyπdιnecarboxaldehyde (201.0μl; 2.11mmol), followed by acetic acid (lml). The mixture was stirred for 30 minutes then sodium cyanoborohydride (199mg; 3.16mmol) was added. The reaction mixture was stirred overnight, then water was added and the mixture extracted with methylene chloπde. The aqueous phase was neutralized with sodium bicarbonate and was extracted again with methylene chloπde. Combined methylene chloπde extracts were dπed over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase puπfication. (M+l) calculated: 456.60, (M+l) observed: 456.12 Anal.: calculated for (C 29 H 33 Ν 3 0 2 X 1.70 C 2 H0 2 F 3 X 0.40 H 2 0): C:59.26%; H:5.45%; N:6.40%; found: C:59.21%; H:5.46%; N:6.35% 'HNMR (CD 3 OD): 8.57 (d, IH, J=5.2Hz), 7.78 (dt, IH, J=8.0, 1.2Hz), 7.38 (d, IH, J=8.0Hz), 7.34 (dd, IH, J=8.0, 5.2Hz), 7.24 (d, 2H, J=8.0Hz), 7.15 (d, 2H, J=8.0Hz), 7.05 (t, IH, J=8.0Hz), 6.59 (dd, IH, J=8.0, 2.4Hz), 6.54 (d, IH, J=8.0Hz), 6.45 (dd, IH, J=2.4, 1.2Hz), 4.39 (s, 2H), 3.40-3.46 (m, 2H), 3.26-3.34 (m, 4H), 3.16-3.22 (m, 2H), 2.54-2.64 (m, 4H), 1.13 (t, 3H, J=6.4Hz), 1.01 (t, 3H, J=6.4Hz) Example 8 Preparation of N,N-diethyl-4-{(3-hvdroxyphenyl)ri-(4-pyridinylmethyl)-4- piperidinylidenelmethyllbenzam.de (compound 15) To a room temperature solution of secondary amine (300mg; 0.82mmol) in methanol (8ml) was added 4-pyπdιnecarboxaldehyde (236μl; 2.47mmol), followed by acetic acid (0.5ml). The mixture was stirred for 30 minutes then sodium cyanoborohydπde (155mg; 2.47mmol) was added. The reaction mixture was stirred overnight, quenched with sodium bicarbonate and extracted with methylene chloride. Combined methylene chloπde extracts were dned over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase puπfication. (M+l) calculated: 456.60, (M+l) observed: 456.10 Anal.: calculated for (C 29 H 33 Ν 3 O 2 X 1.80 C 2 HO 2 F 3 X 0.40 H 2 O): C:58.61%; H:5.37%; N:6.29%; found: C:58.64%; H:5.32%; N:6.46% 1HNMR (CD 3 OD): 8.64 (s, 2H), 7.61 (d, 2H, J=5.2Hz), 7.25 (2H, J=8.0Hz), 7.14 (d, 2H, J=8.0Hz), 7.05 (t, IH, J=8.0Hz), 6.59 (dd, IH, J=8.0, 1.6Hz), 6.53 (d, IH, J=8.0Hz), 6.43- 6.46 (m, IH), 4.34 (s, 2H), 3.42-3.44 (m, 2H), 3.18-3.24 (m, 6H), 2.54-2.57 (m, 4H), 1.13 (t, 3H, J=6.4Hz), 1.02 (t, 3H, J=6.4Hz) Example 9 Preparation of N,N-diethyl-4-{(3-hvdroxyphenvI)fl-(lH-imidazol-2-ylmethyl)-4- piperidinylidene1methyllbenzam.de (compound 16) To a room temperature solution of secondary amine (300mg, 0.82mmol) in methanol (8ml) was added 2-ιmιdazolecarboxaldehyde (237.3mg; 2.47mmol), followed by acetic acid (0.5ml) and sodium cyanoborohydπde (155mg; 2.47mmol) The reaction mixture was stirred overnight, quenched with sodium bicarbonate and extracted with methylene chloπde. Combined methylene chloπde extracts were dπed over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase puπfication (M+l) calculated: 445.58, (M+l) observed: 445.16 Anal., calculated for (C 27 H 32 Ν 4 0 2 X 2.10 C 2 HO 2 F 3 X 0 50 H 2 0). C.54.07%, H:5.11%, N:8.08%, found: C:54.04%; H:5.05%; N:8.09% 1 HNMR (CD 3 OD): 7.38 (s, 2H), 7.20-7.22 (m, 2H), 7.11 (d, 2H, J=8.0Hz), 7.0 (t, IH, J=8.0Hz), 6.55 (dd, IH, J=8.0, 3.6Hz), 6.49-6.50 (m, IH), 6.42-6.43 (m, IH), 4.08 (s, 2H), 3.41-3.43 (m, 2H), 3.18-3.20 (m, 3H), 2.79-2.82 (m, 4H), 2.39-2.45 (m, 4H). 1.08-1.16 (m, 3H), 0.96-1.16 (m, 3H) Example 10 Preparation of N,N-diethyl-4-((3-hvdroxyphenyl)ri-(lH-imidazol-4-ylmethyl)-4- piperidinylidenelmethyljbenzamide (compound 17) To a room temperature solution of secondary amine (300mg; 0.82mmol) in methanol (10ml) was added 4(5)-ιmιdazolecarboxaldehyde (94 9mg; 0 99mmol), followed by acetic acid (0.5ml). The mixture was stirred 1 hour then sodium cyanoborohydπde (62.1mg; 0.99mmol) The reaction mixture was stirred overnight, quenched with sodium bicarbonate and extracted with methylene chloride Combined methylene chloπde extracts were dπed over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase puπfication. (M+l) calculated: 445.58, (M+l) observed: 445.16 Anal.: calculated for (C 27 H 32 N 4 0 2 X 2.20 C 2 H0 2 F 3 ): C:54.23%; H:4.96%; N:8.06%; found: C:54.43%; H:4.99%; N:7.73% 'HNMR (CD 3 OD): 8.54 (s, IH), 7.57 (s, IH), 7.23 (d, 2H, J=8.4Hz), 7.13 (d, 2H, J=8.0Hz), 7.03 (dd. IH, J=8.0, 7.6Hz), 6.57-6.59 (m, IH), 6.51-6.53 (m, IH), 6.43-6.44 (m, IH), 4.35 (s, 2H), 3.41-3.43 (m, 2H), 3.18-3.23 (m, 8H), 2.53-2.56 (m, 4H), 1.08-1.16 (m, 3H), 0.96-1.04 (m, 3H) Example 11 Preparation of N,N-diethyl-4-{(3-hvdroxyphenyl)ri-(l,3-thiazol-2-ylmethyl)-4- piperidinylidenelmethyllbenzamide (compound 18) To a room temperature solution of secondary amine (143.2mg; 0.39mmol) in methanol (4ml) was added 2-thιazolecarboxaldehyde (41.4ul; 0.47mmol), followed by acetic acid (0.2ml). The mixture was stirred 1 hour then sodium cyanoborohydride (129.6mg; 1.48mmol). The reaction mixture was stirred overnight, quenched with sodium bicarbonate and extracted with methylene chloride. Combined methylene chloride extracts were dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. Reverse phase puπfication. (M+l) calculated: 462.63, (M+l) observed: 462.10 Anal.: calculated for (C 27 H 31 Ν 3 0 2 S X 1.10 X 1.10 H 2 O): C:57.79%; H:5.70%; N:6.92%; found: C:57.75%; H:5.60%; N:7.13% 'HNMR (CD 3 OD). 7.86 (d, IH, J=4.0Hz), 7.68 (d, IH, J=4.0Hz), 7.26 (d, 2H, J=8.0Hz), 7.16 (d, 2H, J=8.0Hz), 7 07 (dd, IH, J=8.4, 8.0Hz), 6.60-6.62 (m, IH), 6.54-6.56 (m, IH), 6.46-6.47 (m, IH), 4.65 (s, 2H), 3.21-3.45 (m, 8H), 2.56-2.58 (m, 4H), 1.12-1.20 (m, 3H), 1.00-1.08 (m, 3H) Pharmaceutical compositions The novel compounds according to the present invention may be administered orally, intramuscularly, subcutaneously, topically, intranasally, intrapeπtoneally, intrathoracially, intravenously, epidurally, lntrathecally, mtracerebroventncularly and by injection into the joints. A preferred route of administration is orally, intravenously or intramuscularly. The dosage will depend on the route of administration, the seventy of the disease, age and weight of the patient and other factors normally considered by the attending physician, when determining the individual regimen and dosage level as the most appropπate for a particular patient. For prepaπng pharmaceutical compositions from the compounds of this invention, inert, pharmaceutically acceptable earners can be either solid or liquid. Solid form preparations include powders, tablets, dispersible granules, capsules, cachets, and suppositoπes. A solid earner can be one or more substances which may also act as diluents, flavoring agents, solubihzers, lubπcants, suspending agents, binders, or tablet disintegrating agents, it can also be an encapsulating matenal. In powders, the earner is a finely divided solid which is in a mixture with the finely divided active component. In tablets, the active component is mixed with the earner having the necessary binding properties in suitable proportions and compacted in the shape and size desired. For prepaπng suppository compositions, a low-melting wax such as a mixture of fatty acid glycendes and cocoa butter is first melted and the active ingredient is dispersed therein by, for example, stirnng. The molten homogeneous mixture is then poured into convenient sized molds and allowed to cool and solidify. Suitable earners are magnesium carbonate, magnesium stearate, talc, lactose, sugar, pectin, dextnn, starch, tragacanth, methyl cellulose, sodium carboxymethyl cellulose, a low- melting wax, cocoa butter, and the like. Salts include, but are not limited to, pharmaceutically acceptable salts. Examples of pharmaceutically acceptable salts within the scope of the present invention include. acetate, benzenesulfonate, benzoate, bicarbonate, bitartrate, bromide, calcium acetate, camsylate, carbonate, chlonde, citrate, dihydrochloπde, edetate, edisylate, estolate, esylate, fumarate, glucaptate, gluconate, glutamate, glycollylarsamlate, hexylresorcinate, hydrabamine, hydrobromide, hydrochloπde, hydroxynaphthoate, lsethionate, lactate, lactobionate, malate, maleate, mandelate, mesylate, methylbromide, methylnitrate, methylsulfate, mucate, napsylate, nitrate, pamoate (embonate), pantothenate, phosphate/diphosphate, polygalacturonate, sahcylate, stearate, subacetate, succinate, sulfate, tannate, tartrate, teoclate, tnethiodide, benzathme, chloroprocaine, chohne, diethanolamme, ethylenediamine, meglumine, procaine, aluminium, calcium, lithium, magnesium, potassium, sodium, and zinc. Examples of pharmaceutically unacceptable salts within the scope of the present invention include- hydroiodide, perchlorate, tetrafluoroborate. Preferred pharmaceutically acceptable salts are hydrochloπdes, sulfates and bitartrates. The hydrochloπde and sulfate salts are particularly preferred. The term composition is intended to include the formulation of the active component with encapsulating mateπal as a earner providing a capsule in which the active component (with or without other earners) is surrounded by a earner which is thus in association with it Similarly, cachets are included. Tablets, powders, cachets, and capsules can be used as solid dosage forms suitable for oral administration. Liquid from compositions include solutions, suspensions, and emulsions Stenle water or water-propylene glycol solutions of the active compounds may be mentioned as an example of liquid preparations suitable for parenteral administration. Liquid compositions can also be formulated in solution in aqueous polyethylene glycol solution. Aqueous solutions for oral administration can be prepared by dissolving the active component in water and adding suitable colorants, flavoπng agents, stabilizers, and thickening agents as desired. Aqueous suspensions for oral use can be made by dispersing the finely divided active component in water together with a viscous matenal such as natural synthetic gums, resins, methyl cellulose, sodium carboxymethyl cellulose, and other suspending agents known to the pharmaceutical formulation art. Preferably the pharmaceutical compositions is in unit dosage form. In such form, the composition is divided into unit doses containing appropπate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of the preparations, for example, packeted tablets, capsules, and powders in vials or ampoules. The unit dosage form can also be a capsule, cachet, or tablet itself, or it can be the appropriate number of any of these packaged forms BIOLOGICAL EVALUATION In vitro model Cell culture A. Human 293S cells expressing cloned human μ, δ, and K receptors and neomycin resistance were grown in suspension at 37°C and 5% C0 2 in shaker flasks containing calcium-free DMEM10% FBS, 5% BCS, 0.1% Pluromc F-68, and 600 μg ml geneticm B. Mouse and rat brains were weighed and πnsed in ice-cold PBS (containing 2.5mM EDTA, pH 7 4) The brains were homogenized with a polytron for 15 sec (mouse) or 30 sec (rat) in ice-cold lysis buffer (50mM Tns, pH 7.0, 2.5mM EDTA. with phenylmethylsulfonyl fluonde added just prior use to 0.5MmM from a 0.5M stock in DMSO:ethanol). Membrane preparation Cells were pelleted and resuspended in lysis buffer (50 mM Tns, pH 7.0, 2.5 mM EDTA, with PMSF added just pnor to use to 0.1 mM from a 0.1 M stock in ethanol), incubated on ice for 15 mm, then homogenized with a polytron for 30 sec. The suspension was spun at lOOOg (max) for 10 mm at 4°C. The supernatant was saved on ice and the pellets resuspended and spun as before. The supernatants from both spins were combined and spun at 46,000 g(max) for 30 mm. The pellets were resuspended in cold Tns buffer (50 mM Tns/Cl, pH 7.0) and spun again. The final pellets were resuspended in membrane buffer ( 50 mM Tns, 0.32 M sucrose, pH 7.0). Aliquots (1 ml) in polypropylene tubes were frozen in dry ice/ethanol and stored at -70°C until use. The protein concentrations were determined by a modified Lowry assay with SDS. Binding assays Membranes were thawed at 37°C, cooled on ice, passed 3 times through a 25-gauge needle, and diluted into binding buffer (50 mM Tns, 3 M MgCl 2 , 1 mg/ml BSA (Sigma A-7888), pH 7.4, which was stored at 4°C after filtration through a 0.22 m filter, and to which had been freshly added 5 μg/ml aprotinin, 10 μM bestatin, 10 μM diprotm A, no DTT). Aliquots of 100 μl were added to iced 12x75 mm polypropylene tubes containing 100 μl of the appropπate radiohgand and 100 μl of test compound at vanous concentrations. Total (TB) and nonspecific (NS) binding were determined in the absence and presence of 10 μM naloxone respectively. The tubes were vortexed and incubated at 25°C for 60-75 mm, after which time the contents are rapidly vacuum-filtered and washed with about 12 ml/tube iced wash buffer (50 mM Tns, pH 7.0, 3 mM MgCl 2 ) through GF/B filters (Whatman) presoaked for at least 2h in 0 1% polyethyleneimine. The radioactivity (dpm) retained on the filters was measured with a beta counter after soaking the filters for at least 12h in mini vials containing 6-7 ml scintillation fluid. If the assay is set up in 96- place deep well plates, the filtration is over 96-place PEI-soaked unifilters, which were washed with 3 x 1 ml wash buffer, and dπed in an oven at 55°C for 2h. The filter plates were counted in a TopCount (Packard) after adding 50 μl MS-20 scintillation fluid/well. Functional Assays The agonist activity of the compounds is measured by determining the degree to which the compounds receptor complex activates the binding of GTP to G-protems to which the receptors are coupled. In the GTP binding assay, GTP[γ] 35 S is combined with test compounds and membranes from HEK-293S cells expressing the cloned human opioid receptors or from homogenised rat and mouse brain. Agonists stimulate GTP[γ] j5 S binding in these membranes. The EC50 and E max values of compounds are determined from dose- response curves. Right shifts of the dose response curve by the delta antagonist naltπndole are performed to veπfy that agonist activity is mediated through delta receptors. Data analysis The specific binding (SB) was calculated as TB-NS, and the SB in the presence of vanous test compounds was expressed as percentage of control SB Values of IC50 and Hill coefficient (njj) for ligands in displacing specifically bound radioligand were calculated from logit plots or curve fitting programs such as Ligand, GraphPad Pnsm, SigmaPlot, or ReceptorFit Values of K, were calculated from the Cheng-Prussoff equation. Mean ± S.E.M. values of IC50 . K, and njj were reported for ligands tested in at least three displacement curves. Biological data are tabulated in Table 1 on the following pages. Table 1 (continued): Biological data. Receptor saturation expenments Radioligand Kδ values were determined by performing the binding assays on cell membranes with the appropnate radiohgands at concentrations ranging from 0.2 to 5 times the estimated Kδ (up to 10 times if amounts of radioligand required are feasible) The specific radioligand binding was expressed as pmole/mg membrane protein Values of Kδ and B max from individual expenments were obtained from nonlinear fits of specifically bound (B) vs. nM free (F) radioligand from individual according to a one-site model. 0 DETERMINATION OF MECHANO-ALLODYNIA USING VON FREY TESTING Testing was performed between 08.00 and 16:00h using the method descπbed by Chaplan et al. (1994) Rats were placed in Plexiglas cages on top of a wire mesh bottom which allowed access to the paw, and were left to habituate for 10-15 min. The area tested was 5 the mid-plantar left hind paw, avoiding the less sensitive foot pads. The paw was touched with a seπes of 8 Von Frey hairs with loganthmically incremental stiffness (0.41, 0.69, 1.20, 2.04, 3 63, 5.50, 8.51, and 15.14 grams; Stoelting, 111, USA) The von Frey hair was applied from underneath the mesh floor perpendicular to the plantar surface with sufficient force to cause a slight buckling against the paw, and held for approximately 6-8 seconds. A o positive response was noted if the paw was sharply withdrawn. Flinching immediately upon removal of the hair was also considered a positive response. Ambulation was considered an ambiguous response, and in such cases the stimulus was repeated. TESTING PROTOCOL The animals were tested on postoperative day 1 for the FCA-treated group. The 50% withdrawal threshold was determined using the up-down method of Dixon (1980). Testing D was started with the 2.04 g hair, in the middle of the senes. Stimuli were always presented in a consecutive way, whether ascending or descending In the absence of a paw withdrawal response to the initially selected hair, a stronger stimulus was presented; in the event of paw withdrawal, the next weaker stimulus was chosen Optimal threshold calculation by this method requires 6 responses in the immediate vicinity of the 50% 0 threshold, and counting of these 6 responses began when the first change in response occurred, e.g the threshold was first crossed In cases where thresholds fell outside the range of stimuli, values of 15.14 (normal sensitivity) or 0.41 (maximally allodynic) were respectively assigned. The resulting pattern of positive and negative responses was tabulated using the convention, X = no withdrawal; O = withdrawal, and the 50% s withdrawal threshold was interpolated using the formula: 50% g threshold = 10 (Xf + V / 10.000 where Xf = value of the last von Frey hair used (log units); k = tabular value (from Chaplan o et al. (1994)) for the pattern of positive / negative responses, and δ = mean difference between stimuli (log units). Here δ = 0.224. Von Frey thresholds were converted to percent of maximum possible effect (% MPE), according to Chaplan et al. 1994 The following equation was used to compute % MPE. 5 % MPE = Drug treated threshold (g) - allodvnia threshold (g) X 100 Control threshold (g) - allodynia threshold (g) ADMINISTRATION OF TEST SUBSTANCE Rats were injected (subcutaneously, mtrapentoneally, intravenously or orally) with a test substance pnor to von Frey testing, the time between administration of test compound and the von Frey test vaned depending upon the nature of the test compound WRITHING TEST Acetic acid will bπng abdominal contractions when administered mtrapentoneally in mice. These will then extend their body in a typical pattern When analgesic drugs are administered, this descnbed movement is less frequently observed and the drug selected as a potential good candidate. A complete and typical Wπthing reflex is considered only when the following elements are present: the animal is not m movement; the lower back is slightly depressed; the plantar aspect of both paws is observable. In this assay, compounds of the present invention demonstrate significant inhibition of wπthing responses after oral dosing of l-100μmol/kg. (i) Solutions preparation Acetic acid (AcOH): 120 μL of Acetic Acid is added to 19.88 ml of distilled water in order to obtain a final volume of 20 ml with a final concentration of 0.6% AcOH. The solution is then mixed (vortex) and ready for injection. Compound (drug): Each compound is prepared and dissolved in the most suitable vehicle according to standard procedures. (ii) Solutions administration The compound (drug) is administered orally, mtrapentoneally (l.p ) , subcutaneously (s c ) or intravenously (i.v.)) at 10 ml/kg (consideπng the average mice body weight) 20, 30 or 40 minutes (according to the class of compound and its charactenstics) pnor to testing When the compound is delivered centrally: Intraventπcularly (1 c v ) or intrathecally (l.t.) a volume of 5 μL is administered The AcOH is administered mtrapentoneally (i.p.) in two sites at 10 ml/kg (considering the average mice body weight) immediately pnor to testing (iii) Testing The animal (mouse) is observed for a peπod of 20 minutes and the number of occasions (Wnthing reflex) noted and compiled at the end of the expeπment. Mice are kept in individual "shoe box" cages with contact bedding A total of 4 mice are usually observed at the same time: one control and three doses of drug

Claims: Claims 1. A compound of the formula I wherein R is selected from any one of (i) phenyl; (ii) pyridinyl (iii) thienyl (iv) furanyl £ ) \\ lι (v) lmidazolyl ,N, (vi) tπazolyl ^ <\ N-N H (vn) thiazolyl where each R phenyl πng and R heteroaromatic ring may independently be further substituted by 1, 2 or 3 substituents selected from straight and branched Ci-Cβ alkyl, NO 7 , CF3, Ci-C alkoxy, chloro, fluoro, bromo, and iodo, as well as salts thereof. 2. A compound according to claim 1, wherein each R phenyl nng and R heteroaromatic πng may independently be further substituted by 1, 2 or 3 substituents selected from methyl, CF3, chloro, fluoro, bromo, and iodo. 3. A compound according to claim 1, wherein each R phenyl nng and R heteroaromatic ring may independently be further substituted by a methyl group. 4. A compound according to claim 1, wherein R is pyπdinyl, thienyl or furanyl. 5. A compound according to claim 1, selected from any one of • N,N-Dιethyl-4-(3-hydroxylphenyl-N-benzyl-pιpeπdιn-4-ylιdene-methyl)-benzamιde; • N,N-dιethyl-4-{ (3-hydroxyphenyl)[l-(2-thιenylmethyl)-4- pιpendιnylιdene]methyl } benzamide, • N,N-dιethyl-4-{(3-hydroxyphenyl)[l-(3-thιenylmethyl)-4- pιpeπdιnyhdene]methyl } benzamide, • N,N-dιethyl-4-[[l-(2-furylmethyl)-4-pιpeπdmyhdene](3- hydroxyphenyl)methyl]benzamιde, • /V,N-dιethyl-4-[[l (3-furylmethyl)-4-pιpendmylιdene](3- hydroxyphenyl)methyl]benzamιde, • N,N-dιethyl-4-{ (3-hydroxyphenyl) [l-(2-pyπdιny lmethyl)-4- pipendinyhdenejmethyl } benzamide, • N,N-dιethyl-4-{ (3-hydroxyphenyl)[l-(4-pyndιnylmethyl)-4- pιpeπdιnyhdene]methyl } benzamide, • N,N-dιethyl-4-{(3-hydroxyphenyl)[l-(lH-ιmιdazol-2-ylmethyl)-4- pιpeπdιnyhdene]methyl }benzarmde, • N,N-dιethyl-4-{ (3-hydroxyphenyl)[l-(lH-ιmιdazol-4-ylmethyl)-4- pιpeπdιnyhdene]methyl } benzamide, and • N,N-dιethyl-4-{ (3-hydroxyphenyl)[l-(l,3-thιazol-2-ylmethyl)-4- pipendiny hdene]methy 1 } benzamide 6 A compound according to any of the preceding claims, in form of its hydrochlonde, dihydrochloπde, sulfate, tartrate, ditπfluoroacetate or citrate salts 7. A process for prepaπng a compound of formula I, comprising the reaction of, reacting a compound of the general formula II wherein PG is a urethane or benzyl-like protecting group, such as Boc, with 3- hydroxyphenyl boronic acid, using a palladium catalyst in the presence of a base to give the compounds of general formula III, which is thereafter deprotected, under standard conditions and alkylated under rreedduuccttiivvee ccoonnddiittiioonnss wwiitthh aa ccoommppoouurnd of the general formula R -CHO to give compounds of the general formula I. 8. A compound according to claim 1 for use in therapy. 9 A compound according to claim 8, wherein the therapy is pain management 10. A compound according to claim 8, wherein the therapy is dπected towards gastrointestinal disorders. 11. A compound according to claim 8, wherein the therapy is directed towards spinal injuries 12. A compound according to claim 8, wherein the therapy is directed to disorders of the sympathetic nervous system 13. Use of a compound according to formula I of claim 1 for the manufacture of a medicament for use in the treatment of pain., gastrointestinal disorders or spinal injuπes. 14. A pharmaceutical composition compπsmg a compound of the formula I according to claim 1 as an active ingredient, together with a pharmaceutically acceptable ^ earner. 15. A method for the treatment of pain, whereby an effective amount of a compound of the formula I according to claim 1 is administered to a subject in need of pain management. 16. A method for the treatment of gastrointestinal disorders, whereby an effective amount of a compound of the formula I according to claim 1, is administered to a subject suffenng from said gastrointestinal disorder. 17. A method for the treatment of spinal injuπes, whereby an effective amount of a compound of the formula I according to claim 1, is administered to a subject suffenng from said spinal injury 18. A compound of the general formula II wherein PG is a urethane or benzyl-like protecting group.

Inventors: BROWN WILLIAM, WALPOLE CHRISTOPHER, BROWN, WILLIAM, WALPOLE, CHRISTOPHER
Applicants: ASTRAZENECA AB, BROWN WILLIAM, WALPOLE CHRISTOPHER, BROWN, WILLIAM, WALPOLE, CHRISTOPHER
Application year: 2001
Main classification: C07D401
IPC codes: A61K31, A61P1, A61P25, C07D211, C07D401, C07D405, C07D409, C07D417