COMPOSITION WITH A BASE OF A THERAPEUTICALLY ACTIVE COMPOUND, IN PARTICULAR HONEY, FOR THE TREATMENT OF WOUNDS

Abstract: The present invention relates to a composition with a base of a therapeutically active compound, in particular honey, for the treatment of wounds. More in particular, the present invention relates to the use of a honey-containing composition for the preparation of a substance for the treatment of wounds.

Description: COMPOSITION WITH A BASE OF A THERAPEUTICALLY ACTIVE COMPOUND, IN PARTICULAR HONEY, FOR THE TREATMENT OF WOUNDS The invention relates to a method for manufacturing an insulated tube or pipe. The invention further relates to a device for it, as well as to an insulated tube or pipe itself. Insulated tubes or pipes are used for conducting cooling medium, such as in cooling systems, and heating medium, such as in central heating systems, or both, in air treatment systems. The pipe itself is made of copper or synthetic material. The insulation is provided by an insulation casing, for instance of polyethylene foam, to be arranged around the pipe, on which casing a protective outer layer of synthetic foil may have been arranged. The insulation casings are supplied in lengths or as rolls, and are arranged around the pipes at the location of the installation, which may take place by axially sliding or by sliding the casing from aside around the pipe. A drawback of this is that the supply of both parts takes place separately, and that a lot of air and therefore unused volume is carried along with the casings. The arrangement of the casings requires a lot of effort, in which it cannot be guaranteed that the casing in longitudinal direction is perfectly contiguous. Furthermore it is a drawback that at the location two stocks have to be kept. That also holds good for the supplier, who moreover has to purchase from two plants, namely the plant for pipes and the plant for casings. It is an object of the invention to improve on this. To that end, from one aspect, the invention provides a method for manufacturing an assembly of a heat-insulation tube and at least one pipe accommodated therein for transport of fluid, in which in a continuous consecutive series of process Composition with a base of a therapeutically active compound, in particular honey, for the treatment of wounds. The present invention relates to a composition with a base of a therapeutically active compound, in particular honey, for the treatment of wounds, which composition furthermore comprises lanolin and/or a lanolin derivative. More in particular, the present invention relates to the use of a honey-containing composition for the preparation of a substance for the treatment of wounds. Such a composition is known per se from US patent no. 5,785,972. The composition that is known therefrom comprises a therapeutically active compound with antiseptic, osmotic and further characteristics, which composition is used in particular for the treatment of burns and open wounds experienced by animals and man and in particular for the treatment of thermal burns on humans by use of a spray composition. This composition comprises a combination of colloidal silver, raw honey and helichrysum oil , emulsified with an emulsifying agent so as to form a solution. Water soluble lecithin is mentioned as a suitable emulsifying agent. Raw honey is believed to provide antiseptic qualities and to retard the loss of fluids from the trauma site. Additional information with regard to the honey that is used therein is not provided, whilst moreover the emphasis is laid on the antibacter al activity of the emulsion that is used. Honey based substances for the treatment of wounds are furthermore known from European patent application no. 0692 254, French patent application no. 2 773 711 and US patent no. 5,980,875. Further information with regard to the special honey cannot be derived therefrom, however. The object of the present invention is to provide a composition with a base of honey as a therapeutically active compound, which composition is suitable for the treatment of wounds, such as first- degree and second-degree burns, open wounds (chronic wounds), diabetic 2 foot wounds, bedsores (decubitus) and other skin wounds. According to the present invention, the composition as referred to in the introduction is characterized in that the honey has a peroxide number > 5 μg/g honey. hour, measured at 21 °C. The present combination of honey having the present peroxide number, lanolin and/or a lanolin derivative has appeared to be suitable for the treatment of chronic wounds, whereby in particular low- allergen type lanolin is sued. If honey having a peroxide count outside the aforesaid range is used, the desired antibacterial activity of the honey will be 'insufficient. A honey having a peroxide number > 5 μg/g honey.hour, measured at 21 °C, helps stimulate the cell division (mitosis) both of the cells in the dermis and of the cells in the epidermis. The term "lanolin and/or lanolin derivative" as used in the present description includes, besides lanolin, a complex mixture of esters, diesters and hydroxy esters of high molecular weight lanolin alcohols and high molecular weight lanolin acids. Lanolin, which can be considered as a by-product of the wool industry, is an agent which exhibits a strong softening activity, which, by subjective evaluation, has a softening or improving effect on dry or rough skin caused by the absence of an adequate natural moisture retention. Lanolin thus helps maintain or restore the required skin moisture content. Preferably, the present composition furthermore comprises zinc oxide, in particular zinc oxide having a particle size < 0.1.μm. The use of zinc oxide has a positive effect on the wound healing process, in particular as a result of the production of an insulin-like growth factor. Preferably, the present invention furthermore comprises one or more additional components selected from the group of antioxidants, fully trans retinoinic acid (vitamin A acid) or derivatives therefrom, polyunsaturated fatty acids, n-hexacosanol , bis(maltolato) 3 oxovanadium(IV) , aloe vera, calendula oil , ascorbyl palmitate, ascorbic acid, vitamin E, thickener, such as carboxymethyl cellulose, polyethylene glycol and starch, which may or may not be modified. Especially preferred is vitamin A or a derivative therefrom, for example a vitamin A-containing composition such as cod- liver oil. Vitamin A can be considered to be a precursor of vitamin A acid and is conducive to the healing of wounds. The addition thereof is in particular desirable if a patient's healing process is retarded, for example due to the administration of corticosteroids. It is assumed that vitamin A or a derivative therefrom stimulates the production of type I and type II collagen. In specific embodiments it is furthermore desirable to add propolis, a bee product which is known to those skilled in the art, to the present substance, in particular for the treatment of radiation wounds. Calendula oil is in particular preferred because it is believed to have a therapeutic effect. In addition to this, it is desirable to use a compound having both hydrophilic and lipophilic properties, such as ascorbyl palmitate. The honey which is used in the present composition is in particular preferred to possess one or more special properties. As described above, it is in particular desirable for the honey to have a peroxide number > 5 μg/g honey. hour, measured at 21 ° C. If honey having a peroxide number outside the aforesaid range is used, the desired antibacterial activity of the honey will be insufficient. If a cosmetic skin ointment is desired, for which the antibacterial activity is not critical, it may be desirable in certain embodiments to add simple sugars (glucose and fructose, saccharose) to the honey. Since the present composition is directly applied to the wound, the honey that is used is in particular preferred to be sterile. Sterile honey can be obtained by subjecting it to a sterilization treatment, in particular sterilization by means of gamma rays, for example gamma rays from cobalt 60. Experiments have shown that the honey retains its antibacterial activity after such radiation. The special requirement that the honey used in the composition be sterile obtains in particular with regard to a number of uses, for example in the treatment of otitis extra, inflammation in the nose, or in the treatment of a breastfeeding mother's cracked nipples. It should be understood, however, that such a sterilisation treatment is to be considered optional. In a special embodiment, the honey that is used in the present invention is in particular preferred to be free from heavy metals, pesticides and herbicides. This is in particular desirable because the present composition is directly applied to the skin wound. The amount of honey that is used in the present composition ranges from 5-95 wt. %, in particular from 10-90 wt. %, based on the weight of the overall composition. The amount of lanolin and/or lanolin derivative that is used in the present composition ranges from 5-95 wt. %, in particular from 10-90 wt. %, based on the weight of the overall composition. The amount of zinc oxide that is used in the present composition ranges from 0.5-10 wt. , in particular from 1.5-5 wt. %, based on the weight of the overall composition. The amount of the aforesaid additional components in the present composition preferably ranges from 10-50 wt. %, based on the weight of the overall composition. If the amount of honey does not fall within the aforesaid range, the special activity of the present composition for the treatment of wounds will not be observed to a sufficient degree. Inadequate therapeutic activity will also be observed if the amount of lanolin and/or lanolin derivative does not fall within the aforesaid range. The same obtains with regard to the amount of zinc oxide and/or additional components that are used in the present composition. The present composition can be used both in the form of a liquid solution and in the form of an ointment. The present invention will now be explained by means of a number of examples. Comparative example 1. Pure honey having a peroxide count of 0.0 μg/g honey. hour, measured at 21 °C, was applied to the wound site of a person having serious decubitus. Although a slight improvement in the healing process of the bedsores was achieved in comparison with the situation wherein no substance was applied, the patient experienced undesirable pain. Comparative example 2. A composition consisting of 10 wt. % of lanolin and 90 wt.% of honey having a peroxide count of 3 μg/g honey. our, measured at 21 °C, was used with a group of patients having serious decubitus. The healing of the wounds was slightly accelerated, albeit to an insufficient degree. Example 1. A composition consisting of 10 wt. % of lanolin and 90 wt.% of honey was used with a group of patients having serious decubitus.. The honey had a peroxide count of 25 μg/g honey. hour, measured at 21 ° C. The bedsores healed remarkably fast, a reduction upwards of 20% was observed, whereby in addition the pain that was experienced in comparative example 1 was fully gone. Example 2. The composition of example 1 was used, with this difference that additional 3 wt. % of zinc oxide was used. The healing rate was comparable to that of example 1, with this difference that the stimulation of the production of an insulin-like growth factor slightly accelerated the healing of the wounds. Example 3. The composition of example 2 was used, with this difference that additional 15 wt. % of cod-liver oil was used. A group of patients having open wounds who were treated with this composition exhibited a very fast healing process, whereby in addition the skin fully recovered its smooth surface structure. Comparative example 3. A composition consisting of 95 wt. % of lanolin and 5 wt. % of zinc oxide was used with a group of patients having deep grazes. Although this composition, which had a peroxide count of 0.0 μg/g honey. hour, measured at 21 °C, exhibited some therapeutic activity, the time it took for the wounds to heal was considerably longer than in the situation wherein a composition was used which contained honey in addition to lanolin. Example 4. A composition consisting of 50 wt. % of lanolin and 50 wt.% of honey having a peroxide count of 8 μg/g honey. hour, measured at 21 ° C, was used with a group of patients having deep grazes. The composition was experienced as pleasant by the patients, and the wounds were healed within two weeks.

Claims: CLAIMS 1. A composition with a base of a therapeutically active compound, in particular honey, for the treatment of wounds, which composition furthermore comprises lanolin and/or a lanolin derivative, characterized in that said honey has a peroxide number > 5 μg/g honey. hour, measured at 21 °C. 2. A composition according to claim 1, characterized in that low-allergen type lanolin is used. 3. A composition according to claims 1 - 2, characterized in that said composition furthermore comprises zinc oxide. 4. A composition according to claims 3, characterized in that zinc oxide having a particle size < 0.1 μm is used. 5. A composition according to claims 1 - 4, characterized in that said composition comprises one or more additional components selected from the group of antioxidants, fully trans vitamin A acid, polyunsaturated fatty acids, n-hexacosanol , bis(malto.lato) oxovanadium(IV) , aloe vera, calendula oil , ascorbyl palmitate, ascorbic acid, vitamin E, thickener, such as carboxymethyl cellulose, polyethylene glycol and starch, which may or may not be modified. 6. A composition according to claims 1- 5, characterized in that said honey has been subjected to a sterilization treatment, in particular sterilization by means of gamma rays 7. A composition according to claims 1 - 6, characterized in that said honey is free from heavy metals, pesticides and herbicides. 8. A composition according to claims 1 - 7, characterized in that the amount of honey ranges from 5-95 wt. %, based on the weight of the overall composition. 9. A composition according to claims 1 - 7, characterized in that the amount of lanolin and/or lanolin derivative ranges from 5-95 wt.%, based on the weight of the overall composition. 8 10. A composition according to claims 1 - 7, characterized in that the amount of zinc oxide ranges from 0.5-10 wt. %, based on the weight of the overall composition. 11. A composition according to claims 1 - 7, characterized in that amount of additional components as referred to in claim 5 ranges from 10-50 wt. %, based on the weight of the overall composition. 12. A composition according to claims 1 - 11, characterized in that it is applied in the form of a liquid solution. 13. A composition according to claims 1 - 11, characterized in that it is applied in the form of an ointment. 14. Use of the composition according to claims 1 - 13 for the preparation of a substance for the treatment of wounds.

Inventors: POSTMES THEODORE JUSTIN LOUIS, POSTMES, THEODORE, JUSTIN, LOUIS, JOSEPH
Applicants: POSTMES THEODORE JUSTIN LOUIS, TRITICUM EXPLOITATIE B V, POSTMES, THEODORE, JUSTIN, LOUIS, JOSEPH, TRITICUM EXPLOITATIE B.V.
Application year: 2001
Main classification: A61K47
IPC codes: A61K9, A61K35, A61K47