CHEMICAL COMPOUNDS

Abstract: The invention relates to compounds of the formula (I): wherein: ring C is 9 or 10-membered bicyclic heteroaromatic group containing at least one nitrogen atom in the ring attached to Z and optionally containing a further 1-3 heteroatoms, selected independenly from 0, S, and N, with the proviso that ring C is not a quinazoline, quinoline or cinnoline group; either any one of G1, G2, G3, G4 and G5 is nitrogen and the other four are -CH-, or G1, G2, G3, G4 and G5 are all -CH-; Z is -O-, NH-, -S-, CH2- or a direct substituents R<1> may be attached at any free carbon atom of the indole, azaindole or indazole group; m is an integer from 0 to 2; R<b> represents hydrogen or another value as defined herein; R<1> represents hydrogen, hydroxy, halogeno, C1-4alkyl, or any other value as defined herein; R<2> represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C1-3alkyl, C1-3alkoxy, C1-3alkylsulphanyl, -NR<3>R<4> (wherein R<3> and R<4>, which may be the same or different, each represents hydrogen or C1-3alkyl), or R<5>X<1> -(wherein R<5> and X<1> are as defined herein) and salts thereof, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient ans the use of a compound of formula (I) in the manufacture of a medicament for the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease state including cancer ad rheumatoid arthritis.

Description: CHEMICAL COMPOUNDS The present invention relates to indole, azaindole and indazole derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability, to their use as medicaments and to their use in the manufacture of medicaments for use in the production of antiangio genie and/or vascular permeability reducing effects in warm-blooded animals such as humans. Normal angiogenesis plays an important role in a variety of processes including embryonic development, wound healing and several components of female reproductive function. Undesirable or pathological angiogenesis has been associated with disease states including diabetic retinopathy, psoriasis, cancer, rheumatoid arthritis, atheroma, Kaposi's sarcoma and haemangioma (Fan et al, 1995, Trends Pharmacol. Sci. 16: 57-66; Folkman, 1995, Nature Medicine 1 : 27-31). Alteration of vascular permeability is thought to play a role in both normal and pathological physiological processes (Cullinan-Bove et al, 1993, Endocrinology 133: 829-837; Senger et al, 1993, Cancer and Metastasis Reviews, 12: 303- 324). Several polypeptides with in vitro endothelial cell growth promoting activity have been identified including, acidic and basic fibroblast growth factors (aFGF & bFGF) and vascular endothelial growth factor (VEGF). By virtue ofthe restricted expression of its receptors, the growth factor activity of VEGF, in contrast to that ofthe FGFs, is relatively specific towards endothelial cells. Recent evidence indicates that VEGF is an important stimulator of both normal and pathological angiogenesis (Jakeman et al, 1993, Endocrinology, 133: 848-859; Kolch et al, 1995, Breast Cancer Research and Treatment, 36:139-155) and vascular permeability (Connolly et al, 1989, J. Biol. Chem. 264: 20017-20024). Antagonism of VEGF action by sequestration of VEGF with antibody can result in inhibition of tumour growth (Kim et al, 1993, Nature 362: 841-844). Basic FGF (bFGF) is a potent stimulator of angiogenesis (e.g. Hayek et al, 1987, Biochem. Biophys. Res. Commun. 147: 876-880) and raised levels of FGFs have been found in the serum (Fujimoto et al, 1991, Biochem. Biophys. Res. Commun. 180: 386-392) and urine (Nguyen et al, 1993, J. Natl. Cancer, h st. 85: 241-242) of patients with cancer. Receptor tyrosine kinases (RTKs) are important in the transmission of biochemical signals across the plasma membrane of cells. These transmembrane molecules characteristically consist of an extracellular ligand-binding domain connected through a segment in the plasma membrane to an intracellular tyrosine kinase domain. Binding of ligand to the receptor results in stimulation ofthe receptor-associated tyrosine kinase activity which leads to phosphorylation of tyrosine residues on both the receptor and other intracellular molecules. These changes in tyrosine phosphorylation initiate a signalling cascade leading to a variety of cellular responses. To date, at least nineteen distinct RTK subfamilies, defined by amino acid sequence homology, have been identified. One of these subfamilies is presently comprised by the fins-like tyrosine kinase receptor, Fit or Fltl, the kinase insert domain-containing receptor, KDR (also referred to as Flk-1), and another fins-like tyrosine kinase receptor, Flt4. Two of these related RTKs, Fit and KDR, have been shown to bind VEGF with high affinity (De Vries et al, 1992, Science 255: 989-991; Teπnan et al, 1992, Biochem. Biophys. Res. Comm. 1992, 187: 1579-1586). Binding of VEGF to these receptors expressed in heterologous cells has been associated with changes in the tyrosine phosphorylation status of cellular proteins and calcium fluxes. The present invention is based on the discovery of compounds that surprisingly inhibit the effects of VEGF, a property of value in the treatment of disease states associated with angiogenesis and/or increased vascular permeability such as cancer, diabetes, psoriasis, rheumatoid arthritis, Kaposi's sarcoma, haemangioma, acute and chronic nephropathies, atheroma, arterial restenosis, autoimmune diseases, acute inflammation, excessive scar formation and adhesions, lymphoedema, endometriosis, dysfunctional uterine bleeding and ocular diseases with retinal vessel proliferation. Compounds ofthe present invention generally possess higher potency against VEGF receptor tyrosine kinase than against epidermal growth factor (EGF) receptor tyrosine kinase. Compounds ofthe invention which have been tested possess activity against VEGF receptor tyrosine kinase such that they may be used in an amount sufficient to inhibit VEGF receptor tyrosine kinase whilst demonstrating no significant activity against EGF receptor tyrosine kinase. Compounds ofthe present invention generally possess higher potency against VEGF receptor tyrosine kinase than against FGF RI receptor tyrosine kinase. Compounds ofthe invention which have been tested possess activity against VEGF receptor tyrosine kinase such that they may be used in an amount sufficient to inhibit VEGF receptor tyrosine kinase whilst demonstiating no significant activity against FGF RI receptor tyrosine kinase. According to one aspect ofthe present invention there is provided the use of a compound ofthe formula I: (I) wherein: ring C is a 9 or 10-membered bicychc heteroaromatic group containing at least one nitrogen atom in the ring attached to Z and optionally containing a further 1-3 heteroatoms, selected independently from O, S and N, with the proviso that ring C is not a quinazoline, quinoline or cinnoline group; either any one of G_, G 2 , G 3 , G 4 and G 5 is nitrogen and the other four are -CH-, or Gi, G , G 3 , G 4 and G 5 are all -CH-; Z is -O-, -NH-, -S-, -CH - or a direct bond; Z is linked to any one of G l5 G 2 , G 3 and G which is a free carbon atom; n is an integer from 0 to 5; any ofthe substituents R 1 maybe attached at any free carbon atom ofthe indole, azaindole or indazole group, such free carbon atoms maybe Gi, G 2 , G 3 , G or G 5 or may be at the 3-position ofthe indole, azaindole or indazole group; m is an integer from 0 to 2; R represents hydrogen, Cι -4 alkyl, Cι- 4 alkoxyC 1- alkyl, aminoC_. 4 alkyl, C 1-3 all ylammoC_- 4 alkyl, di(C 1-3 alkyl)aminoC 1-4 alkyl, C 2 . 5 alkenylaminoC 1 - 4 alkyl, C 2-5 alkynylaminoC 1-4 alkyl, - Cι- 5 alkyl(ring A) wherein ring A is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholino and thiomorpholino and wherein ring A may bear one or more substituents selected from C 1-4 alkyl, C 2-5 alkenyl, C 2 - 5 alkynyl, hydroxy, oxo, halogeno, cyano, cyanoC 1-4 alkyl, C 1 . alkylsulphonyl and C 1-4 alkanoyl; R 1 represents hydrogen, oxo, hydroxy, halogeno, Cι -4 alkyl, Cι- alkoxy, C 1 - alkoxyC 1- alkyl, aminoC_- 4 alkyl, C 1 . 3 alkylaminoC 1 - 4 alkyl, di(C 1 - 3 alkyl)aminoC 1 - 4 alkyl, B) wherein ring B is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N- methylpiperazinyl, N-ethylpiperazinyl, morpholino and thiomorpholino; R 2 represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C 1-3 alkyl, C_. 3 alkoxy, Cι. 3 alkylsulphanyl, -NR 3 R 4 (wherein R 3 and R 4 , which may be the same or different, each represents hydrogen or Cι- 3 alkyl), or R 5 X l - (wherein X 1 represents a direct bond, -O-, - CH 2 -, -OC(O)-, -C(O)-, -S-, -SO-, -SO2-, -NR 6 C(O)-, -C(O)NR 7 -, -SO 2 NR 8 -, -NR 9 SO 2 - or - NR 10 - (wherein R 6 , R 7 , R 8 , R 9 and R 10 each independently represents hydrogen, C^alkyl or Cι_ alkoxyC 2 - 3 alkyl), and R 5 is selected from one ofthe following twenty-two groups: 1) hydrogen, oxiranylC_- alkyl or C_. 5 alkyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, chloro, bromo and amino; 2) C 1 - 5 alkylX 2 C(O)R 11 (wherein X 2 represents -O- or -NR 12 - (in which R 12 represents hydrogen, Cι_ 3 alkyl or -salkoxyCz-: . alkyl) and R 11 represents Ci- 3 alkyl, -NR 13 R 14 or -OR 15 (wherein R 13 , R 14 and R 15 which may be the same or different each represents hydrogen, C \ . 5 alkyl or C 1-3 alkoxyC 2-3 alkyl)); 3) C^alky ^R 16 (wherein X 3 represents -O-, -S-, -SO-, -SO 2 -, -OC(O)-, -NR 17 C(O)-, - C(O)NR 18 -, -SO 2 NR 19 -, -NR 20 SO 2 - or -NR 21 - (wherein R 17 , R 18 , R 19 , R 20 and R 21 each independently represents hydrogen, C_- 3 alkyl or C 1 - 3 alkoxyC 2-3 alkyl) and R represents hydrogen, Cι -3 alkyl, cyclopentyl, cyclohexyl or a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S andN, which C -3 alkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and C^alkoxy and which cyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C_. 4 cyanoalkyl, Ci- 4 alkyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy, C 1-4 alkoxyCι- 4 alkyl, C \ . 4 alkylsulphonylC_- 4 alkyl, C 1-4 alkoxycarbonyl, C 1- alkylamino, di(Cι- 4 alkyl)amino, di(C 1-4 alkyl)aminoCι. 4 alkoxy and a group -(-O-) f (C 1- alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C 1- alkyl)); 4) -salkylX^-salky ^R 22 (wherein X 4 and X 5 which maybe the same or different are each -O-, -S-, -SO-, -SO 2 -, -NR 23 C(O)-, -C(O)NR 24 -, -SO 2 NR 25 -, -NR 26 SO 2 - or -NR 27 - (wherein R , R , R , R and R each independently represents hydrogen, Cι- 3 alkyl or C_. 3 alkoxyC 2 - 3 alkyl) and R 22 represents hydrogen, C . .. 3 alkyl or C 1 . 3 alkoxyC 2 _ 3 alkyl); 5) R 28 (wherein R 28 is a A-, 5- or 6-membered saturated heterocyclic group (linked via carbon or nitrogen) with 1-2 heteroatoms, selected independently from O, S and N, which heterocyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1 . 4 cyanoalkyl, C 1- alkyl, C 1-4 hydroxyalkyl, Cι- 4 alkoxy, C 1-4 alkoxyC 1-4 alkyl, Ci- 4 alkylsulphonyl, C 1- alkylsulphonylC 1- alkyl, C_. 4 alkoxycarbonyl, C 1-4 aminoalkyl, C \ . alkylamino, di(C 1- alkyl)amino, C t ^alkylaminoCi^alkyl, di(C 1 - alkyl)aminoC 1- alkyl, C_- alkylaminoC 1-4 alkoxy, di(C 1-4 alkyl)aminoC 1-4 alkoxy and a group (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S andN, which cyclic group may bear one or more substituents selected from C h alky!)); 6) Ci -5 alkylR 28 (wherein R 28 is as defined hereinbefore); 7) C 2-5 alkenylR 28 (wherein R 28 is as defined hereinbefore); 8) C - 5 alkynylR 2S (wherein R 28 is as defined hereinbefore); 9) R 29 (wherein R 29 represents a pyridone group, a phenyl group or a 5-6-membered aromatic heterocyclic group (linked via carbon or nitrogen) with 1-3 heteroatoms selected from O, N and S, which pyridone, phenyl or aromatic heterocyclic group may carry up to 5 substituents selected from hydroxy, halogeno, amino, C 1-4 alkyl, Cι- alkoxy, C hydroxyalkyl, C \ . 4 aminoalkyl, ^alkylamino, Cι- 4 hydroxyalkoxy, carboxy, trifluoromethyl, cyano, - C(O)NR 30 R 31 , -NR 32 C(O)R 33 (wherein R 30 , R 31 , R 32 and R 33 , which may be the same or different, each represents hydrogen, C-*. 4 alkyl or C_- 3 alkoxyC 2-3 alkyl) and a group -(-O-) f (Cι- alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S andN, which cyclic group may bear one or more substituents selected from C-*. 4 alkyl)); 10) C 1-5 alkylR 29 (wherein R 29 is as defined hereinbefore); 11) C 2-5 alkenylR 29 (wherein R 29 is as defined hereinbefore); 12) C 2-5 alkynylR 29 (wherein R 29 is as defined hereinbefore); 13) C_- 5 alkylX 6 R 29 (wherein X 6 represents -O-, -S-, -SO-, -SO 2 -, -NR 34 C(O)-, -C(O)NR 35 -, - SO 2 NR 36 -, -NR 37 SO 2 - or -NR 38 - (wherein R 34 , R 35 , R 36 , R 37 and R 38 each independently represents hydrogen, C^alkyl or C_. 3 alkoxyC 2 - 3 alkyl) and R 29 is as defined hereinbefore); 14) C 2 . 5 alkenylX 7 R 29 (wherein X 7 represents -O-, -S-, -SO-, -SO 2 -, -NR 39 C(O)-, -C(O)NR 40 -, -SO 2 NR 41 -, -NR 42 SO 2 - or -NR 43 - (wherein R 39 , R 40 , R 41 , R 42 and R 43 each independently represents hydrogen, C- . . 3 alkyl or C-*_ 3 alkoxyC 2 . 3 alkyl) and R 29 is as defined hereinbefore); 15) C 2 - 5 alkynylX 8 R 29 (wherein X 8 represents -O-, -S-, -SO-, -SO 2 -, -NR 44 C(O)-, -C(O)NR 45 -, 5 -SO 2 NR 46 -, -NR 47 SO 2 - or -NR 48 - (wherein R 44 , R 45 , R 46 , R 47 and R 48 each independently represents hydrogen, C^alkyl or C 1 . 3 alkoxyC 2-3 alkyl) and R 29 is as defined hereinbefore); 16) Cι -4 alkylX 9 C 1 - 4 alkylR 29 (wherein X 9 represents -O-, -S-, -SO-, -SO 2 -, -NR 49 C(O)-, - C(O)NR 50 -, -SO 2 NR 51 -, -NR 52 SO 2 - or -NR 53 - (wherein R 49 , R 50 , R 51 , R 52 and R 53 each independently represents hydrogen, C-* - 3 alkyl or C 1 - 3 alkoxyC 2-3 alkyl) and R 29 is as defined 10 hereinbefore); 17) C 1- alkylX 9 C 1- alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 18) C - 5 alkenyl which maybe unsubstituted or which maybe substituted with one or more groups selected from hydroxy, fluoro, amino, C 1- alkylamino, N,N-di(C . - 4 alkyl)amino, aminosulphonyl, N-C 1-4 alkylaminosulphonyl and N,N-di(Cι -4 alkyl)aminosulphonyl; 15 19) C -5 alkynyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, C_ -4 alkylamino, N,N-di(C_- 4 alkyl)amino, aminosulphonyl, N-Cι- 4 a_kylaminosulphonyl and N,N-di(Cι- 4 alkyl)aminosulphonyl; 20) C 2 - 5 alkenylX 9 C_- alkylR 28 (wherein X 9 andR 28 are as defined hereinbefore); 21) C 2 - 5 alkynylX Cι- 4 alkylR (wherein X and R are as defined hereinbefore); and 20 22) Cι -4 alkylR 54 (Cι- alkyl) q (X 9 ) r R 55 (wherein X 9 is as defined hereinbefore, q is 0 or 1, r is 0 or 1, and R 54 and R 55 are each independently selected from hydrogen, C_- 3 alkyl, cyclopentyl, cyclohexyl and a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which C 1-3 alkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and C 1- alkoxy and which cyclic group may bear 1 or 2 25 substituents selected from oxo, hydroxy, halogeno, cyano, C 1-4 cyanoalkyl, C 1- alkyl, C \ . hydroxyalkyl, Cι. 4 alkoxy, C_. 4 alkoxyCι- alkyl, C_- 4 alkylsulphonylC 1- alkyl, C-_. 4 alkoxycarbonyl, Cι -4 aminoalkyl, 4 alkyl, di(C 1 . 4 a_kyl)aminoC 1-4 alkyl, C 1 - -. alkylaminoC 1- alkoxy, di(C 1- alkyl)aminoC 1-4 alkoxy and a group -(-O-) f (Cι- alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6- 30 membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from Ci- 4 alkyl), with the proviso that R 54 cannot be hydrogen); and additionally wherein any C 1-5 alkyl, C 2 . 5 alkenyl or C -5 alkynyl group in R 5 X l - may bear one or more substituents selected from hydroxy, halogeno and amino); or a salt thereof, or a prodrug thereof for example an ester or an amide, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans. According to another aspect ofthe present invention there is provided the use of a compound ofthe formula I 1 : (I 1 ) wherein: ring C is a 9 or 10-membered bicychc heteroaromatic group containing at least one nitrogen atom in the ring attached to Z and optionally containing a further 1-3 heteroatoms, selected independently from O, S and N, with the proviso that ring C is not a quinazoline, quinoline or cinnoline group; Z is -O-, -NH-, -S-, -CH 2 - or a direct bond; Z is linked to the benz ring ofthe indole group at any ofthe positions 4-, 5-, 6- or 7- ofthe indole group; n is an integer from 0 to 5; any ofthe substitutents R 1 maybe attached at any free carbon atom ofthe indole group, such free carbon atoms may be at positions 2-, 3-, 4-, 5-, 6-, or 7- ofthe indole group; m is an integer from 0 to 2; R b represents hydrogen, C 1-4 alkyl, Cι- alkoxyC 1- _.alkyl, aminoC- . - 4 alkyl, Cι- 3 alkylaminoC_- 4 alkyl, di(C 1-3 alkyl)aminoC 1-4 alkyl, -C_-5alkyl(ring A) wherein ring A is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-methylpiperazinyl, N-ethylpiperazinyl, morpholino and thiomorpholino; R 1 represents hydrogen, oxo, hydroxy, halogeno, C 1- alkyl, Cι_ 4 alkoxy, C_- 4 alkoxyC_. alkyl, aminoCι -4 alkyl, C 1 - 3 alkylaminoC 1- alkyl, di(C 1-3 alkyl)aminoC 1-4 alkyl, -C_- 5 alkyl(ring B) wherein ring B is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N- methylpiperazinyl, N-ethylpiperazinyl, morpholino and thiomorpholino; R 2 represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C 1-3 alkyl, C \ . 3 alkoxy, C 1-3 alkylsulphanyl, -NR 3 R 4 (wherein R 3 and R 4 , which maybe the same or different, each represents hydrogen or Cι. alkyl), or R 5 X*- (wherein X 1 represents a direct bond, -O-, - CH 2 -, -OC(O)-, -C(O)-, -S-, -SO-, -SO 2 -, -NR 6 C(O)-, -C(O)NR 7 -, -SO 2 NR 8 -, -NR 9 SO 2 - or - NR 10 - (wherein R 6 , R 7 , R 8 , R 9 and R 10 each independently represents hydrogen, C 1-3 alkyl or Cι- 3 alkoxyC 2 . 3 alkyl), and R 5 is selected from one ofthe following twenty-two groups: 1) hydrogen, oxiranylC^alkyl or Cι. 5 alkyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, chloro, bromo and amino; 2) Cι -5 alkylX 2 C(O)R π (wherein X 2 represents -O- or -NR 12 - (in which R 12 represents hydrogen, Cι- 3 alkyl or Cι- 3 alkoxyC 2 - 3 alkyl) and R π represents C 1-3 alkyl, -NR 13 R 14 or -OR 15 (wherein R 13 , R 14 and R 15 which may be the same or different each represents hydrogen, C \ . 5 alkyl or C 1 . 3 alkoxyC 2 - 3 alkyl)); 3) C 1-5 alkylX 3 R 16 (wherein X 3 represents -O-, -S-, -SO-, -SO 2 -, -OC(O)-, -NR 17 C(O)-, - C(O)NR 18 -, -SO 2 NR 19 -, -NR 20 SO 2 - or -NR 21 - (wherein R 17 , R 18 , R 19 , R 20 and R 21 each independently represents hydrogen, C 1-3 alkyl or Cι. alkoxyC 2-3 alkyl) and R represents hydrogen, Cι -3 alkyl, cyclopentyl, cyclohexyl or a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which Ci- 3 alkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and Cι. alkoxy and which cyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C_. cyanoalkyl, Cι- alkyl, Cι -4 hydroxyalkyl, Cι- alkoxy, Cι- alkoxyC 1- alkyl, Q- 4 alkylsulphonylCι- alkyl, C 1- alkoxycarbonyl, C 1-4 aminoalkyl, C 1- alkylamino, di(Cι. 4 alkyl)amino, C 1-4 alkylaminoC 1- alkyl, di(C 1-4 alkyl)aminoCι.- 4 alkyl, C 1- alkylaminoC 1-4 alkoxy, di(Cι -4 alkyl)aminoC 1- alkoxy and a group -(-O-) f (C 1-4 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C 1 - 4 alkyl)); 4) C 1 - 5 alkylX 4 Cι- 5 alkylX 5 R 22 (wherein X 4 and X 5 which maybe the same or different are each -O-, -S-, -SO-, -SO 2 -, -NR 23 C(O)-, -C(O)NR 24 -, -SO 2 NR 25 -, -NR 26 SO 2 - or -NR 27 - (wherein R , R , R , R and each independently represents hydrogen, C^alkyl or C . - 3 alkoxyC 2 . 3 alkyl) and R 22 represents hydrogen, C 1-3 alkyl or C 1-3 alkoxy C -3 alkyl); 5) R 28 (wherein R 28 is a 4-, 5- or 6-membered saturated heterocyclic group (linked via carbon or nitrogen) with 1-2 heteroatoms, selected independently from O, S and N, which heterocyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C- . . 4 cyanoalkyl, C- . . 4 alkyl, Cι -4 hydroxyalkyl, Cι- alkoxy, Ci- 4 alkoxyC . . alkyl, C_. 4 alkylsulphonylCι- 4 alkyl, C_- 4 alkoxycarbonyl, C_- alkylamino, di(C- . _ alkyl)amino, Cι- alkylaminoCι- alkyl, di(Cι -4 alkyl)aminoCι. 4 alkyl, C 1-4 alkylaminoCι- alkoxy, di(C 1-4 alkyl)aminoC 1 . alkoxy and a group -(-O-) f (C 1 - 4 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C h alky!)); 6) C 1-5 alkylR 28 (wherein R 28 is as defined hereinbefore); 7) C 2-5 alkenylR 28 (wherein R 28 is as defined hereinbefore); 8) C 2-5 alkynylR 28 (wherein R 28 is as defined hereinbefore); 9) R 29 (wherein R 29 represents a pyridone group, a phenyl group or a 5-6-membered aromatic heterocyclic group (linked via carbon or nitrogen) with 1-3 heteroatoms selected from O, N and S, which pyridone, phenyl or aromatic heterocyclic group may carry up to 5 substituents selected from hydroxy, halogeno, amino, C_. 4 aminoalkyl, C 1-4 alkylamino, C 1-4 hydroxyalkoxy, carboxy, trifluoromethyl, cyano, - C(O)NR 30 R 31 , -NR 32 C(O)R 33 (wherein R 30 , R 31 , R 32 and R 33 , which may be the same or different, each represents hydrogen, C 1- alkyl or C 1 . 3 alkoxyC 2-3 alkyl) and a group -(-O-) f (C 1 . 4 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S andN, which cyclic group may bear one or more substituents selected from C_. alkyι)); 10) C^alkylR 29 (wherein R 29 is as defined hereinbefore); 11) C -5 alkenylR 29 (wherein R 29 is as defined hereinbefore); 12) C 2-5 alkynylR 29 (wherein R 29 is as defined hereinbefore); 13) Cι- 5 alkylX 6 R 29 (wherein X 6 represents -O-, -S-, -SO-, -SO 2 -, -NR 34 C(O)-, -C(O)NR 35 -, - SO 2 NR 36 -, -NR 37 SO 2 - or -NR 38 - (wherein R 34 , R 35 , R 36 , R 37 and R 38 each independently represents hydrogen, C 1-3 alkyl or C_. alkoxyC 2 - 3 alkyl) and R 29 is as defined hereinbefore); 14) C 2 - 5 alkenylX 7 R 29 (wherein X 7 represents -O-, -S-, -SO-, -SO 2 -, -NR 39 C(O)-, -C(O)NR 40 -, -SO 2 NR 41 -, -NR 42 SO 2 - or -NR 43 - (wherein R 39 , R 40 , R 41 , R 42 and R 43 each independently represents hydrogen, C 1-3 alkyl or C 1 . 3 alkoxyC 2-3 alkyl) and R 29 is as defined hereinbefore); 15) C 2 - 5 alkynylX 8 R 29 (wherein X 8 represents -O-, -S-, -SO-, -SO 2 -, -NR 44 C(O)-, -C(O)NR 45 -, 5 -SO 2 NR 46 -, -NR 47 SO 2 - or -NR 48 - (wherein R 44 , R 45 , R 46 , R 47 and R 48 each independently represents hydrogen, C 1-3 alkyl or Cι- alkoxyC . 3 alkyl) and R is as defined hereinbefore); 16) Cι- 4 alkylX 9 Cι- 4 alkylR 29 (wherein X 9 represents -O-, -S-, -SO-, -SO 2 -, -NR 49 C(O)-, - C(O)NR 50 -, -SO 2 NR 51 -, -NR 52 SO 2 - or -NR 53 - (wherein R 49 , R 50 , R 51 , R 52 and R 53 each independently represents hydrogen, C__ 3 alkyl or Cι -3 alkoxyC 2 - 3 alkyl) and R 29 is as defined 10 hereinbefore); 17) C^alky ^C al ylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 18) C - 5 alkenyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, N,N-di(C 1- alkyl)amino, aminosulphonyl, N-Cι- alkylaminosulphonyl and N,N-di(C 1-4 alkyl)aminosulphonyl; 15 19) C 2 - 5 alkynyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, Cι- 4 alkylamino, N,N-di(C_- 4 alkyl)amino, aminosulphonyl, and N,N-di(Cι- alkyl)aminosulphonyl; 20) C 2 - 5 alkenylX 9 C 1 . 4 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 21) C 2-5 alkynylX 9 C 1- alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); and 20 22) C 1-4 alkylR 54 (Cι -4 alkyl) q (X 9 ) r R 55 (wherein X 9 is as defined hereinbefore, q is 0 or 1, r is 0 or 1, and R 54 and R 55 are each independently selected from hydrogen, Cι- 3 alkyl, cyclopentyl, cyclohexyl and a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which Cι -3 alkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and C 1 . 4 alkoxy and which cyclic group may bear 1 or 2 25 substituents selected from oxo, hydroxy, halogeno, cyano, C 1 - cyanoalkyl, C 1- alkyl, . hydroxyalkyl, C 1- alkoxy, Ci- 4 alkoxyC . . alkyl, C alkylsulphonylC^alkyl, Ci- 4 alkoxycarbonyl, C_- aminoalkyl, Cι- alkylamino, di(C 1 . 4 alkyl)amino, C_- 4 alkylarninoCi. 4 alkyl, di(Cι_ alkyl)aminoCι_ 4 alkyl, C 1-4 alkylaminoC 1- alkoxy, and a group -(-O-) f (C 1 - alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6- 30 membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C^alkyl), with the proviso that R 54 cannot be hydrogen); and additionally wherein any C_- 5 alkyl, C 2 . 5 alkenyl or C 2 . 5 alkynyl group in R 5 X - may bear one or more substituents selected from hydroxy, halogeno and amino); or a salt thereof, or a prodrug thereof for example an ester or an amide, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans. Preferably ring C is selected from one ofthe following seven moieties: wherein Z is as defined hereinbefore but is not part of ring C, it is shown for the purpose of clarity, and wherein alternatives for the values at certain positions ofthe rings are indicated by the possible values separated by commas. More preferably ring C is a thienopyrimidine ring or a phthalazine ring. Preferably Z is -O-, -NH-, -S- or a direct bond. More preferably Z is -O-, -NH- or -S-. Particularly Z is -O- or -NH-, especially -O-. Preferably Z is linked to the indole, azaindole or indazole group at the 5- or 6-positions ofthe indole, azaindole or indazole group. More preferably Z is linked to the indole, azaindole or indazole group at the 5-position ofthe indole, azaindole or indazole group. Preferably Z is linked to an indole group at the 5- or 6-positions ofthe indole group. More preferably Z is linked to an indole group at the 5-position ofthe indole group. Preferably R represents hydrogen, C 1-2 alkyl, C 2 . 3 alkenylaminoC 2 - 3 alkyl, C 2 - 3 alkynylaminoC 2 - 3 alkyl or -C 2- alkyl(ring A) wherein ring A is selected from piperidinyl and piperazinyl and wherein ring A may bear one or more substituents selected from Ci- alkyl, C - 3 alkenyl, C 2 . 3 alkynyl, hydroxy, cyano, cyanoC 1- alkyl, C 1-2 alkylsulphonyl and d_ 2 alkanoyl. More preferably R represents hydrogen, methyl, C 2 . alkenylaminoC 2 . 3 alkyl, C 2 . alkynylaminoC 2 - alkyl or -C 2 - 3 alkyl(ring A) wherein ring A is selected from 4- acetylpiperazin-1-yl, 4-methylsulphonylpiperazin-l-yl, 4-cyanopiperazin-l-yl, 4- cyanomethylpiperazin- 1 -yl, 4-(prop-2-en- 1 -yl)piperazin- 1 -yl, 4-(prop-2-yn- 1 -yl)piperazin- 1 -yl and 4-hydroxypiperidino. Particularly R is hydrogen or methyl, especially hydrogen. Advantageously R 1 represents hydrogen, oxo, hydroxy, halogeno, d- 4 alkyl, C \ . 4 alkoxy, C 1 . alkoxyC 1 . 4 alkyl, aminoC 1-4 alkyl, C^salkylaminod^alkyl, di(C 1-3 alkyl)aminoC 1- 4 alkyl, -Ci- 5 alkyl(ring B) wherein ring B is selected from azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, N-methylpiperazin-1-yl, N-ethylpiperazin-1-yl, morpholino and thiomorpholino. Particularly R 1 represents methyl, ethyl, trifluoromethyl or halogeno. Especially R 1 represents methyl, fluoro, chloro or bromo, more especially methyl or fluoro. Preferably n is an integer from 0 to 3. More preferably n is 0, 1 or 2. According to one aspect ofthe present invention Gi is nitrogen and G 2 , G , G 4 and G 5 are -CH- forming an azaindole moiety which may bear one or more substituents R 1 as defined hereinbefore. According to another aspect ofthe present invention G 5 is nitrogen and G_, G 2 , G and G 4 are -CH- forming an indazole moiety which may bear one or more substituents R 1 as defined hereinbefore. According to another aspect ofthe present invention G_, G , G 3 , G 4 and G 5 are all -CH- forming an indole moiety which may bear one or more substituents R 1 as defined hereinbefore. In one embodiment ofthe invention the optionally substituted indole, azaindole or indazole moiety of formula IT: (π) wherein R 1 , R , G ls G 2 , G 3 , G 4 and G 5 and n are as defined hereinbefore; is selected from the indole moieties: 4-fluoro-2-methylindol-5-yl, 2-methylindol-5-yl, 2-methylindol-6-yl, 2,3-dimethylindol-5-yl, l-methylindol-5-yl, l,2-dimethylindol-5-yl, 4-fluoroindol-5-yl, 6-fluoroindol-5-yl, indol-5-yl and 3-methylindol-5-yl, the azaindole moieties: lH-pyrrolo[2,3-tJ]pyridin-5-yl and 2-methyl-lH-pyrrolo[2,3-&]pyridin-5-yl, and the indazole moiety: lH-indazol-5-yl. The indole moieties are preferred over the azaindole and indazole moieties. In one embodiment ofthe invention the optionally substituted indole moiety of formula II 1 : (π 1 ) wherein R , R and n are as defined hereinbefore; is selected from 4-fluoro-2-methylindol-5-yl, 2-methylindol-5-yl, 2-methylindol-6-yl, 2,3- dimethylindol-5-yl, l-methylindol-5-yl, l,2-dimethylindol-5-yl, 4-fluoroindol-5-yl, 6- fluoroindol-5-yl and indol-5-yl. Particularly the optionally substituted indole moiety of formula II is selected from 4-fluoro-2- methylindol-5-yl, 4-fluoroindol-5-yl and 6-fluoroindol-5-yl, more especially from 4-fluoro-2- methylindol-5-yl. Preferably m is 1 or 2. Advantageously X 1 represents a direct bond, -O-, -S-, -NR 6 C(O)-, -NR 9 SO 2 - or - NR 10 - (wherein R 6 , R 9 and R 10 each independently represents hydrogen, Cι- alkyl or C_- 2 alkoxyethyl). Preferably X 1 represents a direct bond, -O-, -S-, -NR 6 C(O)-, -NR 9 SO 2 - (wherein R 6 and R 9 each independently represents hydrogen or d- 2 alkyι) or NH. More preferably X 1 represents -O-, -S-, -NR 6 C(O)- (wherein R 6 represents hydrogen or Cι. 2 alkyl) orNH. Particularly X 1 represents -O- or -NR 6 C(O)- (wherein R 6 represents hydrogen or Ci- 2 alkyl), more particularly -O- or -NHC(O)-, especially -O-. According to another aspect ofthe present invention X 1 represents -O- or a direct bond. Advantageously X 2 represents -O- or NR 12 (wherein R 12 represents hydrogen, d- 3 alkyl or Cι -2 alkoxyethyl). Advantageously X 3 represents -O-, -S-, -SO-, -SO 2 -, -NR 17 C(O)-, -NR 20 SO 2 - or -NR 21 - (wherein R 17 , R 20 and R 21 each independently represents hydrogen, d- 2 alkyl or d- 2 alkoxyethyl). Preferably X 3 represents -O-, -S-, -SO-, -SO 2 - or -NR 21 - (wherein R 21 represents hydrogen, Cι- 2 alkyl or Ci- 2 alkoxyethyl). More preferably X 3 represents -O- or -NR 21 - (wherein R 21 represents hydrogen or C_. 2 alkyl). According to another aspect ofthe present invention X 3 represents -O-, -SO 2 -, - NR 20 SO 2 - or -NR 21 - (wherein R 20 and R 21 each independently represents hydrogen, Cι- 2 alkyl or Ci- 2 alkoxyethyl). Advantageously X 4 and X 5 which may be the same or different each represents -O-, - S-, -SO-, -SO - or -NR 27 - (wherein R 27 represents hydrogen, Cι- 3 alkyl or d^alkoxyethyl). Preferably X 4 and X 5 which may be the same or different each represents -O-, -S- or -NR 27 - (wherein R 27 represents hydrogen, d- 2 alkyl or Cι. 2 alkoxyethyl). More preferably X and X 5 which may be the same or different each represents -O- or -NH-. Especially X 4 and X 5 each represents -O-. Advantageously X represents -O-, -S- or -NR - (wherein R represents hydrogen, Cι- 2 alkyl or C 1-2 alkoxyethyl). Preferably X represents -O- or -NR - (wherein R represents hydrogen or d- 2 alkyl). Especially X 6 represents -O-. Advantageously X 7 represents -O-, -S- or -NR 43 - (wherein R 43 represents hydrogen, C 1-2 alkyl or d- 2 alkoxyethyl). Preferably X 7 represents -O- or -NR 43 - (wherein R 43 represents hydrogen or d- 2 alkyl). Advantageously X 8 represents -O-, -S- or -NR 48 - (wherein R 48 represents hydrogen, C_. 2 alkyl or Ci- 2 alkoxyethyl). Preferably X 8 represents -O- or -NR 48 - (wherein R 48 represents hydrogen or C 1-2 alkyl). Advantageously X 9 represents -O-, -S- or -NR 53 - (wherein R 53 represents hydrogen, Cι- alkyl or C 1-2 alkoxyethyl). Preferably X 9 represents -O- or -NR 53 - (wherein R 53 represents hydrogen or C 1-2 alkyl). According to another aspect ofthe present invention X 9 represents -O-, -CONR 50 - or - NR 53 - (wherein R 50 and R 53 each independently represents hydrogen or d- 2 alkyι). Conveniently R 28 is pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, morpholino or thiomorpholino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, d- 3 cyanoalkyl, C_. 3 alkyl, Ci -- . hydroxyalkyl, C 1-3 alkoxy, Ci- 2 alkoxyd. alkyl, C 1- alkylsulphonylCι- 3 alkyl, Cι. 3 alkoxycarbonyl, Cι. 3 alkylamino, di(d- 3 alkyl)amino, Cι. 3 alkylaminoCi. 3 alkyl, di(d- 3 alkyl)aminoCi- 3 alkyl, Cι. 3 alkylaminoCi -3 alkoxy, di(Cι- 3 alkyl)aminoCι- alkoxy and a group -(-O-) (C 1 - 3 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, morpholino and thiomorpholino, which cyclic group may bear one or more substituents selected from Cι- 3 alkyl). Advantageously R is pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, morpholino or thiomorpholino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Cι- 3 cyanoalkyl, d- alkyl, C_- 3 hydroxyalkyl, d- 3 alkoxy, C 1 _ 2 alkoxyC 1 - alkyl, C 1-2 alkylsulphonyld- 3 alkyl, d- alkoxycarbonyl, C 1-3 alkylamino, di(C 1 . 3 alkyl)amino, d- alkylaminod. 3 alkyl, di(C 1 - 3 alkyl)aminoC 1 _ 3 alkyl, d- 3 alkylaminoCι. 3 alkoxy, di(d- 3 alkyl)aminod- 3 alkoxy and a group -(-O-) f (C_- alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, morpholino and thiomorpholino). 9R In one embodiment ofthe present invention R is pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, morpholino or thiomorpholino which group may bear 1 or 2 substituents selected from a group (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, morpholino and thiomorpholino). Particularly R 28 is pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, morpholino or thiomorpholino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1-3 cyanoalkyl, C 1-3 alkyl, Ci .-.hydroxyalkyl, Cι- 3 alkoxy, d- 2 alkoxyd-:_alkyl and Cι- 2 alkylsulphonyld- 3 alkyl. According to another aspect ofthe present invention, preferably R 28 is pyrrolidinyl, piperazinyl, piperidinyl, morpholino or thiomorpholino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, d- cyanoalkyl, C 1- alkyl, C_. 3 hydroxyalkyl, d- 3 alkoxy, Cι- 2 alkoxyC_- 3 a_kyl and Cι- 2 alkylsulphonyld. alkyl. Where R 29 is a 5 -6-membered aromatic heterocyclic groupi it preferably has 1 or 2 heteroatoms, selected from O, N and S, of which more preferably one is N, and may be substituted as hereinbefore defined. R 29 is particularly a pyridone, phenyl, pyridyl, imidazolyl, thiazolyl, thienyl, triazolyl or pyridazinyl group which group may be substituted as hereinbefore defined, more particularly a pyridone, pyridyl, imidazolyl, thiazolyl or triazolyl group, especially a pyridone, pyridyl, imidazolyl or triazolyl group which group may be substituted as hereinbefore defined. In one embodiment ofthe invention R 29 represents a pyridone, phenyl or 5- 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which group may preferably carry up to 2 substituents, more preferably up to one substituent, selected from the group of substituents as hereinbefore defined. In the definition of R 29 , conveniently substituents are selected from halogeno, C__ alkyl, C 1- alkoxy, cyano and a group -(-O-) f (C 1-3 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, morpholino and thiomorpholino, which cyclic group may bear one or more substituents selected from C 1- alkyl). In the definition of R 29 , more conveniently substituents are selected from chloro, fluoro, methyl, ethyl and a group -(-O-) f (C 1-3 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, morpholino and thiomorpholino). According to another emodiment ofthe present invention in the definition of R 29 , conveniently substituents are selected from halogeno, C 1-4 alkyl, C 1-4 alkoxy and cyano, more conveniently substituents are selected from chloro, fluoro, methyl and ethyl. Advantageously R 54 and R 55 are each independently a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C_. 3 cyanoalkyl, C_. 3 alkyl, d. 3 hydroxyalkyl, d. alkoxy, d- 2 alkoxyCι- alkyl, Ci- 2 alkylsulphonyld- alkyl, d- 3 alkoxycarbonyl and a group -(-O-) f (Cι- 3 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C . -salkyi). Preferably R 5 and R 55 are each selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, morpholino and thiomorpholino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1-3 cyanoalkyl, d- alkyl, d- hydroxyalkyl, C_. 3 alkoxy, d. 2 alkoxyC_- 3 alkyl, C 1-2 alkylsulphonylC 1 - 3 alkyl, d- 3 alkoxycarbonyl and a group -(-O-)_(Cι- 3 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, morpholino and thiomorpholino, which cyclic group may bear one or more substituents selected from C 1-3 alkyl). More preferably R 54 and R 55 are each selected from pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, morpholino and thiomorpholino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1-3 cyanoalkyl, C 1- alkyl, C \ . 3 hydroxyalkyl, d- 3 alkoxy, C 1-2 alkoxyCι. 3 alkyl, Cι_ 2 alkylsulphonylCι. 3 alkyl, Ci- 3 alkoxycarbonyl and a group -(-O-)_{Cι- 3 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, morpholino and thiomorpholino). Particularly R 54 and R 55 are each selected from pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, morpholino and thiomoφholino which group may bear 1 or 2 substituents selected from a group -(-O-) (d- alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino). More particularly R 54 and R 55 are each selected from pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino which group is unsubstituted. Conveniently R 2 represents hydroxy, halogeno, cyano, nitro, trifluoromethyl, dialkyl, amino or R 5 X ! - [wherein X 1 is as hereinbefore defined and R 5 is selected from one ofthe following twenty-two groups: 1) oxiranylC 1-4 alkyl or C 1-5 alkyl which may be unsubstituted or which may be substituted with one or more groups selected from fluoro, chloro and bromo, or dialkyl which may be unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) C 2 - 3 alkylX 2 C(O)R 11 (wherein X 2 is as hereinbefore defined and R 11 represents C_- 3 alkyl, - NR 13 R 14 or -OR 15 (wherein R 13 , R 14 and R 15 which may be the same or different are each d- 4 alkyl or Cι -2 alkoxyethyl)); 3) C 2- alkylX 3 R 16 (wherein X 3 is as hereinbefore defined and R 16 represents hydrogen, Ci- 3 alkyl, cyclopentyl, cyclohexyl or a A-, 5- or 6-membered saturated heterocyclic group with 1- 2 heteroatoms, selected independently from O, S and N, which dialkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and Cι. alkoxy and which cyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Ci- 4 cyanoalkyl, d- alkyl, Cι- hydroxyalkyl, C 1- alkoxy, Cι- alkoxyC 1- alkyl, Cι- 4 alkylsulphonylC 1-4 alkyl, d- 4 alkoxycarbonyl, Cι -4 alkylamino, di(Cι- alkyl)amino, C 1-4 alkylaminoCι -4 alkyl, di(d. 4 alkyl)aminoC 1-4 alkyl, C 1-4 alkylaminoC 1-4 alkoxy, di(C 1-4 alkyl)aminoC 1- alkoxy and a group - (-O-) f (Cι- alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C 1-4 alkyl)); 4) C 2-3 alkylX 4 C 2-3 alkylX 5 R 22 (wherein X 4 and X 5 are as hereinbefore defined and R 22 represents hydrogen or C 1-3 alkyl); 5) R 28 (wherein R 28 is as defined hereinbefore); 6) Ci-salkylR 56 (wherein R 56 is a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which heterocyclic group is linked to Cι- 5 alkyl through a carbon atom and which heterocyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C_- cyanoalkyl, C 1-4 alkyl, C 1-4 hydroxyalkyl, d- alkoxy, d- 4 alkanoyl, d_ alkoxyC_ -4 alkyl, Cj- alkylsulphonyl, Cι- alkylsulphonylC 1-4 alkyl, C 1-4 alkoxycarbonyl, C 1-4 alkylamino, di(Cι. 4 alkyl)amino, C 1 . 4 alkylaminoC 1 - 4 alkyl, di(d- 4 alkyl)aminoC 1- alkyl, C 1-4 alkylaminoCι -4 alkoxy, di(C 1- alkyl)aminoCι -4 alkoxy and a group - (-O-) f (d- alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from Cι- alkyl)) or C 2 - 5 alkylR 57 (wherein R 57 is a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, of which one is N and the other may be selected independently from O, S and N, which heterocyclic group is linked to C 2-5 alkyl through a nitrogen atom and which heterocyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1-4 cyanoalkyl, d- 4 alkyl, Cι- hydroxyalkyl, d- 4 alkoxy, C 1-4 alkanoyl, C_- 4 alkoxyC_- alkyl, d- 4 alkylsulphonyl, C_- alkoxycarbonyl, C 1 . 4 alkylamino, di(d- 4 alkyl)amino, di(C 1 - alkyl)aminoC 1 .4alkyl, Cι -4 alkylaminoC 1-4 alkoxy, di(C 1-4 alkyl)aminoC 1 - 4 alkoxy and a group -(-O-)f(C_- alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from d- 4 alkyl)); 7) C -4 alkenylR 58 (wherein R 58 represents R 56 or R 57 as defined hereinbefore); 5 8) C 3-4 as defined hereinbefore); 9) R 29 (wherein R 29 is as defined hereinbefore); 10) d-salkylR 29 (wherein R 29 is as defined hereinbefore); 11) C 3 - 5 alkenylR 29 (wherein R 29 is as defined hereinbefore); 12) C 3 - 5 alkynylR 29 (wherein R 29 is as defined hereinbefore); 10 13) Ci-salkylX R (wherein X and R are as defined hereinbefore); 7 0 7 90 14) C 4 - 5 alkenylX R (wherein X and R are as defined hereinbefore); 15) C - 5 alkynylX 8 R 29 (wherein X 8 and R 29 are as defined hereinbefore); 16) C 2 - 3 alkylX 9 d. 3 alkylR 29 (wherein X 9 and R 29 are as defined hereinbefore); 17) C 2 . 3 alkylX 9 d- 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 15 18) C 2-5 alkenyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, Cι -4 alkylamino, N,N-di(C_. 4 alkyl)amino, aminosulphonyl, N-C 1-4 alkylaminosulphonyl and N,N-di(C 1-4 alkyl)aminosulphonyl; 19) C 2-5 alkynyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, C 1-4 alkylamino, N,N-di(d- 4 alkyl)amino, 20 aminosulphonyl, N-C 1- alkylaminosulphonyl and N,N-di(C 1- alkyl)aminosulphonyl; 20) C 2 - 5 alkenylX 9 Cι- 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 21) C - 5 alkynylX 9 Ci_ alky_R 28 (wherein X 9 and R 28 are as defined hereinbefore); and 22) Cι -3 alkylR 54 (C_- 3 alkyl) q (X 9 ) r R 55 (wherein X 9 , q, r, R 54 and R 55 are as defined hereinbefore); 25 and additionally wherein any C 1-5 alkyl, C 2 - 5 alkenyl or C 2 - 5 alkynyl group in R 5 X 1 - may bear one or more substituents selected from hydroxy, halogeno and amino]. Advantageously R 2 represents hydroxy, halogeno, cyano, nitro, trifluoromethyl, d- 3 alkyl, amino or R^X 1 - [wherein X 1 is as hereinbefore defined and R 5 is selected from one of the following twenty-two groups: 30 1) d- alkyl which may be unsubstituted or which may be substituted with one or more groups selected from fluoro, chloro and bromo, or C 2 . 5 alkyl which may be unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) C 2 - 3 alkylX 2 C(O)R π (wherein X 2 is as hereinbefore defined and R 11 represents -NR 13 R 14 or -OR 15 (wherein R 13 , R 14 and R 15 which maybe the same or different are each Cι- alkyl or d_ 2 alkoxyethyl)); 3) C 2 - 4 alkylX 3 R 16 (wherein X 3 is as hereinbefore defined and R 16 is a group selected from C_- 3 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl and tetrahydropyranyl, which Cι- alkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and d- 2 alkoxy and which cyclopentyl, cyclohexyl, pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl or tetrahydropyranyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1-3 cyanoalkyl, d. alkyl, d- 3 hydroxyalkyl, Cι- alkoxy, Cι- 2 alkoxyCι. 3 alkyl, Cι- 2 alkylsulphonylC 1-3 alkyl, C_. alkoxycarbonyl, d-salkylamino, di(C 1 - 3 alkyl)amino, C_- 3 alkylaminod- alkyl, di(d- 3 alkyl)aminoC 1-3 alkyl, d- 3 alkylaminod- alkoxy, di(C 1 . alkyl)aminoC 1 - 3 alkoxy and a group - (-O-) f (C 1 - alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, moφholino and thiomoφholino, which cyclic group may bear one or more substituents selected from d- salkyl)); 4) C 2-3 alkylX 4 C 2-3 alkylX 5 R 22 (wherein X 4 and X 5 are as hereinbefore defined and R 22 represents hydrogen or C 1- alkyl); 5) R 28 (wherein R 28 is as defined hereinbefore); 6) C 1-4 alkylR 59 (wherein R 59 is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidin-1-yl, azetidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and 1,3- dithian-2-yl, which group is linked to d. 4 alkyl through a carbon atom and which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Cι- 3 cyanoalkyl, C_- 3 alkyl, d- 3 hydroxyalkyl, d- 3 alkoxy, C 1- alkanoyl, C 1 - 2 alkoxyC 1 . 3 alkyl, C 1-2 alkylsulphonyl, d- 2 alkylsulphonylC 1-3 alkyl, C 1-3 alkoxycarbonyl, C_- 3 alkylamino, di(C 1- alkyl)amino, d. 3 alkylaminoCi. 3 alkyl, di(C 1-3 alkyl)aminoCι- alkyl, C 1 - 3 alkylaminoC 1 - 3 alkoxy, di(C 1 - 3 alkyl)aminoC 1-3 alkoxy and a group -(-O-) f (C 1-3 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, moφholino and thiomoφholino, which cyclic group may bear one or more substituents selected from d- 3 alkyl)) or d^alkylR 60 (wherein R 60 is a group selected from moφholino, thiomoφholino, azetidin-1-yl, pyrrolidin-1-yl, piperazin-1-yl and piperidino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, d_ 3 cyanoalkyl, d. 3 alkyl, d- 3 hydroxyalkyl, d_ 3 alkoxy, C 1-2 alkanoyl, d- 2 alkoxyCi- 3 lkyl, C_. 2 alkylsulphonyl, d-2alkylsulphonylC__ 3 alkyl, d- 3 alkoxycarbonyl, C_- 3 alkylamino, di(C_. 3 a_lcyl)amino, d-salkylaminoC . -salkyl, C 1-3 alkylaminoCι- 3 alkoxy, di(d- 3 aUcyl)aminoC_- 3 alkoxy and a group -(-O- d-salky gringD (wherein f is 0 or 1, g is 0 5 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, moφholino and thiomoφholino, which cyclic group may bear one or more substituents selected from C 1-3 alkyl)); 7) C 3 - 4 alkenylR 61 (wherein R 61 represents R 59 or R 60 as defined hereinbefore); 8) C 3-4 alkynylR 61 (wherein R 61 represents R 59 or R 60 as defined hereinbefore); 10 9) R 29 (wherein R 29 is as defined hereinbefore); 10) C 1-4 alkylR 29 (wherein R 29 is as defined hereinbefore); 11) l-R 29 prop-l-en-3-yl or l-R 29 but-2-en-4-yl (wherein R 29 is as defined hereinbefore with the proviso that when R 5 is l-R 29 prop-l-en-3-yl, R 29 is linked to the alkenyl group via a carbon atom); 15 12) 1-R prop- l-yn-3-yl or 1-R but-2-yn-4-yl (wherein R is as defined hereinbefore with the proviso that when R 5 is l-R 29 prop-l-yn-3-yl, R 29 is linked to the alkynyl group via a carbon atom); 13) C „ . 5 alkylX 6 R 29 (wherein X 6 and R 29 are as defined hereinbefore); 14) l-(R 29 X 7 )but-2-en-4-yl (wherein X 7 and R 29 are as defined hereinbefore); 20 15) 1 -(R 29 X 8 )but-2-yn-4-yl (wherein X 8 and R 29 are as defined hereinbefore); 16) C 2 . 3 alkylX 9 C 1-3 alkylR 29 (wherein X 9 andR 29 are as defined hereinbefore); 17) C 2-3 alkylX 9 C 1-3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 18) C 2-5 alkenyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, d- 25 4 alkylamino, N . N-di(C_- 4 alkyl)amino, aminosulphonyl, N-C 1- alkylaminosulphonyl and N,N- di(d- 4 a_kyl)aminosulphonyl; 19) C 2-5 alkynyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, d- alkylamino, N,N-di(C 1-4 alkyl)amino, aminosulphonyl, N-C 1-4 alkylaminosulphonyl and N,N- 30 di(C 1-4 alkyl)aminosulphonyl; 20) C 2-4 a_kenylX 9 C 1-3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 21) C 2-4 alkynylX 9 Cι- 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); and 22) C 1 . 3 alkylR 54 (C 1 - 3 alkyl) q (X 9 ) r R 55 (wherein X 9 , q, r, R 54 and R 55 are as defined hereinbefore); and additionally wherein any d. 5 alkyl, C 2 - 5 alkenyl or C 2 . 5 alkynyl group in R 5 X 1 - may bear one or more substituents selected from hydroxy, halogeno and amino]. Preferably R 2 represents hydroxy, halogeno, nitro, trifluoromethyl, C_- alkyl, cyano, amino or R 5 X J - [wherein X 1 is as hereinbefore defined and R 5 is selected from one ofthe following twenty groups: 1) d- 3 alkyl which may be unsubstituted or which may be substituted with one or more groups selected from fluoro, chloro and bromo, or C 2- alkyl which may be unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) 2-(3,3-dimethylureido)ethyl, 3-(3,3-dimethylureido)propyl, 2-(3-methylureido)ethyl, 3-(3- methylureido)propyl, 2-ureidoethyl, 3-ureidopropyl, 2-(N,N-dimethylcarbanιoyloxy)ethyl, 3- (N,N-dimethylcarbamoyloxy)propyl, 2-(N-methylcarbamoyloxy)ethyl, 3-(N- methylcarbamoyloxy)propyl, 2-(carbamoyloxy)ethyl, 3-(carbamoyloxy)propyl, or 2-(N- methyl-N-(butoxycarbonyl)amino)ethyl; 3) C 2 . alkylX 3 R 16 (wherein X 3 is as hereinbefore defined and R 16 is a group selected from d- 3 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl, piperidinyl, piperazinyl, azetidinyl, imidazolidinyl and tetrahydropyranyl which group is linked to X 3 through a carbon atom and which C 1-3 alkyl group may bear 1 or 2 substituents selected from hydroxy, halogeno and Ci- 2 alkoxy and which cyclopentyl, cyclohexyl, pyrrolidinyl, piperidinyl, piperazinyl, azetidinyl, imidazolidinyl or tetrahydropyranyl group may bear one substituent selected from oxo, hydroxy, halogeno, cyano, Cι_ 2 cyanoalkyl, C 1-2 alkyl, d ^hydroxyalkyl, C 1-2 alkoxy, d- 2 alkoxyC_- alkyl, d^alkylsulphonyld^alkyl, C 1-2 alkoxycarbonyl, C_. 3 alkylamino, di(d_ 3 alkyl)amino, d-sal ylaminod-salkyl, di(C 1 . 3 alkyl)aminoC 1 - alkyl, C 1 - alkylaminoC 1 - 3 alkoxy, di(d- 3 alkyl)aminoC_- 3 alkoxy and a group -(-O-)f(C_- 3 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyπolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino)); 4) C 2-3 a_kylX 4 C 2-3 alkylX 5 R 22 (wherein X 4 and X 5 are as hereinbefore defined and R 22 represents hydrogen or C 1-2 alkyl); 5) R 28 (wherein R 28 is as defined hereinbefore); 6) C 1-3 alkylR 59 (wherein R 59 is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, imidazolidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and 1,3- dithian-2-yl, which group is linked to d- 3 alkyl through a carbon atom and which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, d- 2 cyanoa_kyl, C_. 2 alkyl, Cι. 2 hydroxyalkyl, C 1-2 alkoxy, d- 2 alkanoyl, C 1 . 2 alkoxyCι- 3 alkyl, C 1 . 2 alkylsulphonyl, C 1-2 alkylsulphonylCι. 3 alkyl, d- 2 alkoxycarbonyl, Cι- alkylamino, di(d- 3 alkyl)amino, d. 5 3 alkylaminoCι- 3 alkyl, di(Cι- 3 alkyl)aminoC 1-3 alkyl, d_ 3 al]^lanιinoCι.. 3 alkoxy, di(C 1 - 3 alkyl)aminoC 1-3 alkoxy and a group -(-O-) f (Cι- 3 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and tliiomoφholino)) or -salkylR 60 (wherein R 60 is a group selected from moφholino, thiomoφholino, azetidin-1-yl, pyrrolidin-1-yl, piperazin-1-yl and piperidino 10 which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Ci- 2 cyanoalkyl, Cμ 2 alkyl, C ^hydroxyalkyl, C 1-2 alkoxy, C 1-2 alkanoyl, Ci- 2 alkoxyCi- 3 alkyl, C_- 2 alkylsulphonyl, Ci- 2 alkylsulphonylCi- 3 alkyl, Ci- 2 alkoxycarbonyl, Ci- 3 alkylarnino, di(d- alkyl)amino, Ci- alkylaminoCi- 3 alkyl, di(C 1 - 3 alkyl)aminoC 1 - 3 alkyl, Cι- 3 alkylaminoCι- 3 alkoxy, di(C 1-3 alkyl)aminoC 1 . 3 alkoxy and a group -(-O-) f (Cι -3 alkyl) g ringD (wherein f is 0 or 1, g is 0 15 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino)); 7) R 29 (wherein R 29 is as defined hereinbefore); 8) Cι- alkylR 29 (wherein R 29 is as defined hereinbefore); 9) l-R 29 but-2-en-4-yl (wherein R 29 is as defined hereinbefore); 20 10) l-R 29 but-2-yn-4-yl (wherein R 29 is as defined hereinbefore); 11) d- 3 alkylX 6 R 29 (wherein X 6 and R 29 are as defined hereinbefore); 12) l-(R 29 X 7 )but-2-en-4-yl (wherein X 7 and R 29 are as defined hereinbefore); 13) l-(R 29 X 8 )but-2-yn-4-yl (wherein X 8 and R 29 are as defined hereinbefore); 14) C 2 - 3 alkylX 9 d- 3 alkylR 29 (wherein X 9 and R 29 are as defined hereinbefore); 25 15) C 2 - 3 alkylX 9 C 1 - 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 16) C 2 - 5 alkenyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, C . . alkylamino, N,N-di(d- 4 alkyl)amino, aminosulphonyl, N-Cι- a_kylaminosulρhonyl and N,N- di(Cι- 4 alkyl)aminosulphonyl; 30 17) C 2 - 5 alkynyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, Ci- 4 alkylamino, N,N-di(C 1 - 4 alkyl)amino, aminosulphonyl, N-C 1-4 alkylaminosulphonyl and N,N- di(C_. alkyl)aminosulphonyl; 18) C 2-3 alkenylX 9 C 1 . 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 19) C 2 - 3 alkynylX 9 Cι- 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); and 20) d- 3 alkylR 54 (Cι- 3 alkyl) q (X 9 ) r R 55 (wherein X 9 , q, r, R 54 and R 55 are as defined hereinbefore); and additionally wherein any d_ alkyl, C 2 . 5 alkenyl or C 2 -salkynyl group in R 5 X J - may bear one or more substituents selected from hydroxy, halogeno and amino]. More preferably R 2 represents hydroxy, C 1-3 alkyl, amino orR^ 1 - [wherein X 1 is as hereinbefore defined and R 5 represents methyl, ethyl, benzyl, trifluoromethyl, 2,2,2- trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-methoxyethyl, 3-methoxypropyl, 2- (methylsulphinyl)ethyl, 2-(methylsulphonyl)ethyl, 2-(ethylsulphinyl)ethyl, 2- (ethylsulphonyl)ethyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, 2- sulphamoylethyl, 2-(methylamino)ethyl, 3-(methylamino)propyl, 2-(ethylamino)ethyl, 3- (ethylamino)propyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-(N,N- diethylamino)ethyl, 3-(N,N-diethylamino)propyl, 2-(N-methyl-N- methylsulphonylamino)ethyl, 3-(N-methyl-N-methylsulphonylamino)propyl, 2- moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2- (methylpiperidino)ethyl, 3-(methylpiρeridino)propyl, 2-(ethylpiperidino)ethyl, 3- (ethylpiperidino)propyl, 2-((2-methoxyethyl)piperidino)ethyl, 3-((2- methoxyethyl)piperidino)propyl, 2-((2-methylsulphonyl)ethylpiperidino)ethyl, 3-((2- methylsulphonyl)ethylpiperidino)propyl, piperidin-3-ylmethyl, piperidin-4-ylmethyl, 2- (piperidin-3-yl)ethyl, 2-(piperidin-4-yl)ethyl, 3-(piperidin-3-yl)propyl, 3-(piperidin-4- yl)propyl, 2-(piρeridin-2-yl)ethyl, 3-(piperidin-2-yl)propyl, (l-methylpiperidin-3-yl)methyl, (l-methylpiperidin-4-yl)methyl, 2-(4-hydroxypiperidino)ethyl, 3-(4-hydroxypiperidino)propyl, (l-cyanomethylpiperidin-3-yl)methyl, (l-cyanomethylρiperidin-4-yl)methyl, 2- (methylpiperidin-3-yl)ethyl, 2-(methylpiρeridin-4-yl)ethyl, 2-(l-cyanomethylpiperidin-3- yl)ethyl, 2-(l-cyanomethylpiperidin-4-yl)ethyl, 3-(methylpiperidin-3-yl)propyl, 3- (methylpiperidin-4-yl)propyl, 3-(l-cyanomethylpiperidin-3-yl)propyl, 3-(l- cyanomethylpiρeridin-4-yl)propyl, 2-(ethylpiperidin-3-yl)ethyl, 2-(ethylpiperidin-4-yl)ethyl, 3- (ethylpiperidin-3-yl)propyl, 3-(ethylpiperidin-4-yl)propyl, ((2-methoxyethyl)piperidin-3- yl)methyl, ((2-methoxyethyl)piperidin-4-yl)methyl, 2-((2-methoxyethyl)piperidin-3-yl)ethyl, 2-((2-methoxyethyl)piperidin-4-yl)ethyl, 3-((2-methoxyethyl)piperidin-3-yl)propyl, 3-((2- methoxyethyl)piperidin-4-yl)propyl, (1 -(2-methylsulphonylethyl)piperidin-3-yl)methyl, (1 -(2- methylsulphonylethyl)piperidin-4-yl)methyl, 2-((2-methylsulphonylethyl)piperidin-3-yl)ethyl, 2-((2-methylsulphonylethyl)piperidin-4-yl)ethyl, 3-((2-methylsulphonylethyl)piperidin-3- yl)ρropyl, 3-((2-methylsulphonylethyl)piperidin-4-yl)propyl, l-isopropylpiperidin-2-ylmethyl, l-isopropylpiperidin-3-ylmethyl, l-isopropylpiperidin-4-ylmethyl, 2-(l-isopropylpiperidin-2- yl)ethyl, 2-(l-isopropylpiperidin-3-yl)ethyl, 2-(l-isopropylpiperidin-4-yl)ethyl, 3-(l- isopropylpiperidin-2-yl)propyl, 3-(l-isopropylpiperidin-3-yl)propyl, 3-(l-isopropylpiperidin- 4-yl)propyl, 2-(piperidin-4-yloxy)ethyl, 3-(piperidin-4-yloxy)propyl, 2-(l- (cyanomethyl)piperidin-4-yloxy)ethyl, 3-(l-(cyanomethyl)piperidin-4-yloxy)propyl, 2-(l-(2- cyanoethyl)piperidin-4-yloxy)ethyl, 3-(l -(2-cyanoethyl)ρiperidin-4-yloxy)propyl, 2- (piperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, (pyrrolidin-2-yl)methyl, 2-(pyrrolidin-l- yl)ethyl, 3-(pyrrolidin-l-yl)propyl, (2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methyl, 5(i?)-(2-oxo- tetrahydro-2H-ρyrrolidin-5-yl)methyl, (5S)-(2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(N-(2- methoxyethyl)-N-methylamino)ethyl, 2-(2-hydroxyethylamino)ethyl, 3 -(2- methoxyethylamino)propyl, 3-(N-(2-methoxyethyl)-N-methylamino)propyl, 3-(2- hydroxyethylamino)propyl, 2-methylthiazol-4-ylmethyl, 2-acetamidothiazol-4-ylmethyl, 1- methylimidazol-2-ylmethyl, 2-(imidazol-l-yl)ethyl, 2-(2-methylimidazol-l-yl)ethyl, 2-(2- ethylimidazol-l-yl)ethyl, 3-(2-methylimidazol-l-yl)propyl, 3-(2-ethylimidazol-l-yl)propyl, 2- (l,2,3-triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4- triazol-4-yl)ethyl, 4-pyridylmethyl, 2-(4-pyridyl)ethyl, 3-(4-pyridyl)propyl, 3-pyridylmethyl, 2- (3-pyridyl)ethyl, 3-(3-pyridyl)propyl, 2-(4-pyridyloxy)ethyl, 2-(4-pyridylamino)ethyl, 2-(4- oxo- 1 ,4-dihydro- 1 -pyridyl)ethyl, 2-(2-oxo-imidazolidin- 1 -yl)ethyl, 3 -(2-oxo-imidazolidin- 1 - yl)propyl, 2-thiomoφholinoethyl, 3-thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-(l , 1 -dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin- 1- yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 2-(4-cyanomethylpiperazin-l-yl)ethyl, 3-(4- cyanomethylpiperazin- 1 -yl)propyl, 2-(4-acetylpiperazin- 1 -yl)ethyl, 3-(4-acetylpiperazin- 1 - yl)propyl, 2-(4-methylsulphonylpiperazin- 1 -yl)ethyl, 3 -(4-methylsulphonylpiperazin- 1 - yl)propyl, 3-(methylsulphinyl)propyl, 3-(methylsulphonyl)propyl, 3-(ethylsulphinyl)propyl, 3- (ethylsulphonyl)propyl, 2-(5-methyl-l,2,4-triazol-l-yl)ethyl, moφholino, 2-((N-(l- methylimidazol-4-ylsulphonyl)-N-methyl)amino)ethyl, 2-((N-(3-moφholinopropylsulphonyl)- N-methyl)amino)ethyl, 2-((N-methyl-N-4-pyridyl)amino)ethyl, 3 -(4-oxidomoφholino)propyl, 2-(2-(4-methylpiperazin-l-yl)ethoxy)ethyl, 3-(2-(4-methylpiperazin-l-yl)ethoxy)propyl, 2-(2- moφholinoethoxy)ethyl, 3-(2-moφholinoethoxy)proρyl, 2-(tetrahydropyran-4-yloxy)ethyl, 3- (tetrahydropyran-4-yloxy)propyl, 2-((2-(pyrrolidin-l-yl)ethyl)carbamoyl)vinyl, 3-((2- (pyrrohdin- 1 -yl)ethyl)carbamoyl)prop-2-en- 1 -yl, 1 -(2-pyrrolidinylethyl)piperidin-4-ylmethyl, l-(3-pyrrolidinylpropyl)piperidin-4-yhnethyl, l-(2-piperidinylethyl)piperidin-4-ylmethyl, l-(3- piperidinylpropyl)piperidin-4-ylmethyl, 1 -(2-moφholinoethyl)piperidin-4-ylmethyl, 1 -(3 - moφholinopropyl)pip eridin-4-ylmethyl, 1 -(2-thiomoφholinoethyl)piperidin-4-ylmethyl, 1 -(3 - thiomoφholinopropyl)piperidin-4-ylmethyl, 1 -(2-azetidinylethyl)piperidin-4-ylmethyl, 1 -(3 - azetidinylpropyl)piperidin-4-ylmethyl, 2-(l-(2-pyrrolidinylethyl)piperidin-4-yl)ethyl, 2-(l-(3- pyπolidinylpropyl)piperidin-4-yl)ethyl, 2-(l-(2-piperidinylethyl)piperidin-4-yl)ethyl, 2-(l-(3- piperidinylpropyl)piperidin-4-yl)ethyl, 2-(l -(2-moφholinoethyl)piperidin-4-yl)ethyl, 2-(l-(3- moφholinopropyl)piperidin-4-yl)ethyl, 2-(l-(2-thiomoφholinoethyl)piperidin-4-yl)ethyl, 2- (l-(3-thiomoφholinoρropyl)piperidin-4-yl)ethyl, 2-(l-(2-azetidinylethyl)piperidin-4-yl)ethyl, 2-(l-(3-azetidinylpropyl)piperidin-4-yl)ethyl, 3-moφholino-2-hydroxypropyl, (2i?)-3- moφholino-2-hydroxypropyl, (2S)-3-moφholino-2-hydroxypropyl, 3-piperidino-2- hydroxypropyl, (2i?)-3-piperidino-2-hydroxypropyl, (2S)-3-piperidino-2-hydroxypropyl, 3- pyrrolidin-1 -yl-2-hydroxypropyl, (2R)-3 -pyrrohdin- 1 -yl-2-hydroxypropyl, (2S)-3-pyrrolidin-l - yl-2-hydroxypropyl, 3 -(1 -methylpiperazin-4-yl)-2-hydroxypropyl, (2i?)-3 -( 1 -methylpiperazin- 4-yl)-2-hydroxypropyl, (2S)-3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, 3-(N,N- diethylamino)-2-hydroxypropyl, (2i?)-3-Qi,N-diethylamino)-2-hydroxypropyl, (2S)-3-(N,N- diethylamino)-2-hydroxypropyl, 3-(isopropylamino)-2-hydroxypropyl, (2i?)-3- (isopropylamino)-2-hydroxypropyl, (2S)-3 -(isopropylamino)-2-hydroxypropyl, 3 -(N,N- diisopropylamino)-2-hydroxypropyl, (2i?)-3-(N,N-diisopropylamino)-2-hydroxypropyl or (2S)-3-(N,N-diisopropylamino)-2-hydroxypropyl] . 9 1 1 Particularly R represents C 1-3 alkyl, amino or R X - [wherein X is as hereinbefore defined and R 5 represents ethyl, benzyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-methoxyethyl, 3-methoxypropyl, 2-(methylsulphinyl)ethyl, 2- (methylsulphonyl)ethyl, 2-(ethylsulphinyl)ethyl, 2-(ethylsulphonyl)ethyl, 2-(N,N- dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, 2-sulphamoylethyl, 2- (methylamino)ethyl, 3-(methylamino)propyl, 2-(ethylamino)ethyl, 3-(ethylamino)propyl, 2- (N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-(N,N-diethylamino)ethyl, 3- (N,N-diethylamino)ρropyl, 2-(N-methyl-N-methylsulphonylamino)ethyl, 3-(N-methyl-N- methylsulphonylamino)propyl, 2-moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3- piperidinopropyl, 2-(methylpiperidino)ethyl, 3-(methylpiperidino)propyl, 2- (ethylpiperidino)ethyl, 3-(ethylpiperidino)propyl, 2-((2-methoxyethyl)piperidino)ethyl, 3-((2- methoxyethyl)piperidino)propyl, 2-((2-methylsulphonyl)ethylpiperidino)ethyl, 3-((2- methylsulphonyl)ethylpiperidino)propyl, piperidin-3-ylmethyl, piperidin-4-ylmethyl, 2- (piperidin-3-yl)ethyl, 2-(piperidin-4-yl)ethyl, 3-(piperidin-3-yl)propyl, 3-(piperidin-4- yl)propyl, 2-(piperidin-2-yl)ethyl, 3-(piperidin-2-yl)propyl, (l-methylρiperidin-3-yl)methyl, (1 -methylpiperidin-4-yl)methyl, 2-(4-hydroxypiperidino)ethyl, 3-(4-hydroxypiperidino)propyl, (l-cyanomethylpiperidin-3-yl)methyl, (l-cyanomethylpiperidin-4-yl)methyl, 2- (methylpiperidin-3-yl)ethyl, 2-(methylpiperidin-4-yl)ethyl, 2-(l-cyanomethylpiperidin-3- yl)ethyl, 2-(l-cyanomethylpiperidin-4-yl)ethyl, 3-(methylpiperidin-3-yl)propyl, 3- (methylpip eridin-4-yl)propyl, 3 -( 1 -cyanomethylpiperidin-3 -yl)propyl, 3 -( 1 - cyanomethylpiperidin-4-yl)propyl, 2-(ethylpiperidin-3-yl)ethyl, 2-(ethylpiperidin-4-yl)ethyl, 3- (ethylpiperidin-3-yl)ρropyl, 3-(ethylpiperidin-4-yl)propyl, ((2-methoxyethyl)piperidin-3- yl)methyl, ((2-methoxyethyl)piperidin-4-yl)methyl, 2-((2-methoxyethyl)piperidin-3-yl)ethyl, 2-((2-methoxyethyl)piperidin-4-yl)ethyl, 3-((2-methoxyethyl)piperidin-3-yl)propyl, 3-((2- methoxyethyl)piperidin-4-yl)propyl, (1 -(2-methylsulphonylethyl)piperidin-3-yl)methyl, (1 -(2- methylsulphonylethyl)piperidin-4-yl)methyl, 2-((2-methylsulphonylethyl)piperidin-3-yl)ethyl, 2-((2-methylsulphonylethyl)piperidin-4-yl)ethyl, 3-((2-methylsulphonylethyl)piperidin-3- yl)propyl, 3 -((2-methylsulphonylethyl)piperidin-4-yl)propyl, 1 -isopropylpiperidin-2-ylmethyl, l-isopropylpiperidin-3-ylmethyl, l-isopropylpiperidin-4-ylmethyl, 2-(l-isopropylpiperidin-2- yl)ethyl, 2-(l-isopropylpiperidin-3-yl)ethyl, 2-(l-isopropylpiperidin-4-yl)ethyl, 3-(l- isopropylpiperidin-2-yl)propyl, 3 -( 1 -isopropylpiperidin-3 -yl)propyl, 3 -( 1 -isopropylpiperidin- 4-yl)propyl, 2-(piperidin-4-yloxy)ethyl, 3-(piperidin-4-yloxy)propyl, 2-(l- (cyanomethyl)piperidin-4-yloxy)ethyl, 3-(l -(cyanomethyl)piperidin-4-yloxy)propyl, 2-(l -(2- cyanoethyl)piperidin-4-yloxy)ethyl, 3-(l-(2-cyanoethyl)piperidin-4-yloxy)propyl, 2- (piperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, (pyrrolidin-2-yl)methyl, 2-(pyrrolidin-l- yl)ethyl, 3-(pyrrolidin-l-yl)propyl, (2-oxo-tetrahydro-2iϊ-pyrrolidin-5-yl)methyl, 5(i?)-(2-oxo- tetrahydro-2H-pyrrolidin-5-yl)methyl, (5S)-(2-oxo-tetrahydro-2i- 7 -pyrrolidin-5-yl)methyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(N-(2- methoxyethyl)-N-methylamino)ethyl, 2-(2-hydroxyethylamino)ethyl, 3 -(2- methoxyethylamino)propyl, 3-(N-(2-methoxyethyl)-N-methylamino)propyl, 3-(2- hydroxyethylamino)propyl, 2-methylthiazol-4-ylmethyl, 2-acetamidothiazol-4-ylmethyl, 1- methylimidazol-2-ylmethyl, 2-(imidazol-l-yl)ethyl, 2-(2-methylimidazol-l-yl)ethyl, 2-(2- ethylimidazol-l-yl)ethyl, 3-(2-methylimidazol-l-yl)propyl, 3-(2-ethylimidazol-l-yl)propyl, 2- (l,2,3-triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4- triazol-4-yl)ethyl, 4-pyridylmethyl, 2-(4-pyridyl)ethyl, 3-(4-pyridyl)propyl, 3-pyridylmethyl, 2- (3-pyridyl)ethyl, 3-(3-pyridyl)propyl, 2-(4-pyridyloxy)ethyl, 2-(4-pyridylamino)ethyl, 2-(4- oxo- 1 ,4-dihydro- 1 -pyridyl)ethyl, 2-(2-oxo-imidazolidin- 1 -yl)ethyl, 3-(2-oxo-imidazolidin- 1 - yl)propyl, 2-thiomoφholinoethyl, 3-thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-(l,l-dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin-l- yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 2-(4-cyanomethylpiperazin-l-yl)ethyl, 3-(4- cyanomethylpiperazin- 1 -yl)propyl, 2-(4-acetylpiperazin- 1 -yl)ethyl, 3-(4-acetylpiperazin- 1 - yl)propyl, 2-(4-methylsulphonylpiρerazin- 1 -yl)ethyl, 3-(4-methylsulρhonylpiperazin- 1 - yl)propyl, 3-(methylsulphinyl)propyl, 3-(methylsulphonyl)propyl, 3-(ethylsulphinyl)propyl, 3- (ethylsulphonyl)propyl, 2-(5-methyl-l,2,4-triazol-l-yl)ethyl, moφholino, 2-((N-(l- methylimidazol-4-ylsulphonyl)-N-methyl)amino)ethyl, 2-((N-(3-moφholinopropylsulphonyl)- N-methyl)amino)ethyl, 2-((N-methyl-N-4-pyridyl)amino)ethyl, 3-(4-oxidomoφholino)propyl, 2-(2-(4-methylpiperazin- 1 -yl)ethoxy)ethyl, 3-(2-(4-methylpiperazin- 1 -yl)ethoxy)propyl, 2-(2- moφholinoethoxy)ethyl, 3-(2-moφholinoethoxy)propyl, 2-(tetrahydropyran-4-yloxy)ethyl, 3- (tetrahydropyran-4-yloxy)ρropyl, 2-((2-(pyrrolidin-l-yl)ethyl)carbamoyl)vinyl, 3-((2- (pyrrolidin- 1 -yl)ethyl)carbamoyl)prop-2-en- 1 -yl, 1 -(2-pyrrolidinylethyl)piperidin-4-ylmethyl, 1 -(3-pyrrolidinylpropyl)piperidin-4-ylmethyl, 1 -(2-piperidinylethyl)piperidin-4-ylmethyl, 1 -(3- piperidinylpropyl)piperidin-4-ylmethyl, 1 -(2-moφholinoethyl)piperidin-4-ylmethyl, 1 -(3- moφholinoρropyl)piperidin-4-ylmethyl, l-(2-thiomoφholinoethyl)piperidin-4-ylmethyl, l-(3- thiomoφholinoproρyl)piperidin-4-ylmethyl, l-(2-azetidinylethyl)piperidin-4-ylmethyl, l-(3- azetidinylpropyl)piperidin-4-ylmethyl, 2-(l-(2-pyrrolidinylethyl)piperidin-4-yl)ethyl, 2-(l-(3- pyrrolidinylpropyl)piperidin-4-yl)ethyl, 2-(l -(2-piperidinylethyl)piperidin-4-yl)ethyl, 2-(l -(3- piperidinylpropyl)piperidin-4-yl)ethyl, 2-(l -(2-moφholinoethyl)piperidin-4-yl)ethyl, 2-(l -(3- moφholinopropyl)piperidin-4-yl)ethyl, 2-(l -(2-thiomoφholinoethyl)piperidin-4-yl)ethyl, 2- (l-(3-thiomoφhohnopropyl)piperidin-4-yl)ethyl, 2-(l-(2-azetidinylethyl)piperidin-4-yl)ethyl, 2-(l-(3-azetidinylpropyl)piperidin-4-yl)ethyl, 3-moφholino-2-hydroxypropyl, (2i?)-3- moφholino-2-hydroxypropyl, (2S)-3-moφholino-2-hydroxypropyl, 3-piperidino-2- hydroxypropyl, (2i?)-3-piperidino-2-hydroxypropyl, (2S)-3-piperidino-2-hydroxypropyl, 3- pyrrolidin- 1 -yl-2-hydroxypropyl, (2R)-3 -pyrrohdin- 1 -yl-2-hydroxypropyl, (2S)-3 -pyrrohdin- 1 - yl-2-hydroxypropyl, 3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, (2i?)-3-(l-methylpiperazin- 4-yl)-2-hydroxypropyl, (2S)-3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, 3-(N,N- diethylamino)-2-hydroxypropyl, (2i?)-3-(N,N-diethylamino)-2-hydroxypropyl, (2S)-3-(N,N- diethylamino)-2-hydroxypropyl, 3 -(isopropylamino)-2-hydroxypropyl, (2R)-3 - (isopropylamino)-2-hydroxypropyl, (2S)-3 -(isopropylamino)-2-hydroxypropyl, 3 -(N,N- diisopropylamino)-2-hydroxypropyl, (2i?)-3-(N,N-diisopropylamino)-2-hydroxypropyl or (2S)-3-(N,N-diisopropylamino)-2-hydroxypropyl]. More particularly R 2 represents d. 3 alkyl, amino or R^ 1 - [wherein X 1 is as hereinbefore defined and R 5 represents ethyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2- hydroxyethyl, 3-hydroxypropyl, 2-methoxyethyl, 3-methoxypropyl, 2-(methylsulphinyl)ethyl, 2-(methylsulphonyl)ethyl, 2-(ethylsulphinyl)ethyl, 2-(ethylsulphonyl)ethyl, 2-(N,N- dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, 2-sulphamoylethyl, 2- (methylamino)ethyl, 3-(methylamino)propyl, 2-(ethylamino)ethyl, 3-(ethylamino)propyl, 2- Q^,N-dimethylamino)ethyl, 3-Q_ ,N-dimethylamino)propyl, 2-(N,N-diethylamino)ethyl, 3- (N,N-diethylamino)propyl, 2-(N-methyl-N-methylsulphonylamino)ethyl, 3-(N-methyl-N- methylsulphonylamino)propyl, 2-moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3- piperidinopropyl, 2-(methylpiperidino)ethyl, 3-(methylpiperidino)propyl, 2- (ethylpiperidino)ethyl, 3-(ethylpiperidino)propyl, 2-((2-methoxyethyl)piperidino)ethyl, 3-((2- methoxyethyl)piperidino)propyl, 2-((2-methylsulphonyl)ethylpiperidino)ethyl, 3-((2- methylsulphonyl)ethylpiρeridino)propyl, piperidin-3-yhnethyl, piperidin-4-ylmethyl, 2- (piperidin-3-yl)ethyl, 2-(piperidin-4-yl)ethyl, 3-(piperidin-3-yl)propyl, 3-(piperidin-4- yl)propyl, 2-(piperidin-2-yl)ethyl, 3-(piperidin-2-yl)propyl, (l-methylpiperidin-3-yl)methyl, (l-methylpiperidin-4-yl)methyl, 2-(4-hydroxypiperidino)ethyl, 3-(4-hydroxypiperidino)propyl, (l-cyanomethylpiperidin-3-yl)methyl, (l-cyanomethylpiperidin-4-yl)methyl, 2- (methylpiperidin-3-yl)ethyl, 2-(methylpiperidin-4-yl)ethyl, 2-(l -cyanomethylpiperidin-3- yl)ethyl, 2-(l-cyanomethylpiperidin-4-yl)ethyl, 3-(methylpiperidin-3-yl)propyl, 3- (methylpiperidin-4-yl)propyl, 3 -(1 -cyanomethylpiperidin-3 -yl)propyl, 3 -(1 - cyanomethylpiperidin-4-yl)propyl, 2-(ethylpiperidin-3-yl)ethyl, 2-(ethylpiperidin-4-yl)ethyl, 3- (ethylpiperidin-3-yl)ρropyI, 3-(ethylpiperidin-4-yl)propyl, ((2-methoxyethyl)piperidin-3- yl)methyl, ((2-methoxyethyl)ρiperidin-4-yl)methyl, 2-((2-methoxyethyl)piperidin-3-yl)ethyl, 2-((2-methoxyethyl)piperidin-4-yl)ethyl, 3-((2-methoxyethyl)piperidin-3-yl)propyl, 3-((2- methoxyethyl)piperidin-4-yl)propyl, (1 -(2-methylsulphonylethyl)piperidin-3-yl)methyl, (1 -(2- methylsulphonylethyl)piperidin-4-yl)methyl, 2-((2-methylsulphonylethyl)piperidin-3-yl)ethyl, 2-((2-methylsulphonylethyl)piperidin-4-yl)ethyl, 3-((2-methylsulphonylethyl)piperidin-3- yl)propyl, 3-((2-methylsulphonylethyl)piperidin-4-yl)propyl, l-isopropylpiperidin-2-ylmethyl, 1 -isopropylpiperidin-3 -ylmethyl, 1 -isopropylpiperidin-4-ylmethyl, 2-( 1 -isopropylpiperidin-2- yl)ethyl, 2-(l-isopropylpiperidin-3-yl)ethyl, 2-(l-isoρroρylpiperidin-4-yl)ethyl, 3-(l- isopropylpiperidin-2-yl)propyl, 3-(l-isopropylpiperidin-3-yl)propyl, 3-(l-isopropylpiperidin- 4-yl)propyl, 2-(piperidin-4-yloxy)ethyl, 3-(piperidin-4-yloxy)propyl, 2-(l- (cyanomethyl)piperidin-4-yloxy)ethyl, 3-(l-(cyanomethyl)piperidin-4-yloxy)propyl, 2-(l-(2- cyanoethyl)piperidin-4-yloxy)ethyl, 3-(l -(2-cyanoethyl)piperidin-4-yloxy)propyl, 2- (piperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, (pyπolidin-2-yl)methyl, 2-(pyrrolidin-l- yl)ethyl, 3 -(pyrrohdin- l-yl)propyl, (2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methyl, 5(i?)-(2-oxo- tetrahydro-2H-pyrrolidin-5-yl)methyl, (5S)-(2-oxo-tetrahydro-2i/ ' -pyrrolidin-5-yl)methyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(N-(2- methoxyethyl)-N-methylamino)ethyl, 2-(2-hydroxyethylamino)ethyl, 3 -(2- methoxyethylamino)propyl, 3-(N-(2-methoxyethyl)-N-methylamino)propyl, 3-(2- hydroxyethylamino)ρropyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 2-(l,2,4- triazol-l-yl)ethyl, 2-(l,2,4-triazol-4-yl)ethyl, 4-pyridylmethyl, 2-(4-ρyridyl)ethyl, 3-(4- pyridyl)propyl, 3-pyridylmethyl, 2-(3-pyridyl)ethyl, 3-(3-pyridyl)propyl, 2-(4- pyridyloxy)ethyl, 2-(4-pyridylamino)ethyl, 2-(4-oxo-l,4-dihydro-l-pyridyl)ethyl, 2-(2-oxo- imidazolidin-l-yl)ethyl, 3-(2-oxo-imidazolidin-l-yl)propyl, 2-thiomoφholinoethyl, 3- thiomoφholinopropyl, 2-(l , l-dioxothiomoφholino)ethyl, 3-(l , 1 -dioxothiomoφholino)propyl, 2-(2-methoxyethoxy) ethyl, 2-(4-methylpiperazin- 1 -yl)ethyl, 3-(4-methylpiperazin- 1 -yl)propyl, 2-(4-cyanomethylpiperazin-l-yl)ethyl, 3-(4-cyanomethylpiperazin-l-yl)propyl, 2-(4- acetylpiperazin- 1 -yl)ethyl, 3-(4-acetylpiperazin- 1 -yl)propyl, 2-(4-methylsulphonylpiperazin- 1 - yl)ethyl, 3-(4-methylsulphonylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3- (methylsulphonyl)propyl, 3-(ethylsulphinyl)propyl, 3-(ethylsulphonyl)ρropyl, 2-(5-methyl- 1 ,2,4-triazol-l-yl)ethyl, moφholino, 2-((N-(3-moφholinopropylsulphonyl)-N- methyl)amino)ethyl, 2-((N-methyl-N-4-pyridyl)ammo)ethyl, 3-(4-oxidomoφholino)propyl, 2- (2-(4-methylpiperazin- 1 -yl)ethoxy)ethyl, 3-(2-(4-methylpiperazin- 1 -yl)ethoxy)propyl, 2-(2- moφholinoethoxy)ethyl, 3-(2-moφholinoethoxy)ρropyl, 2-(tetrahydropyran-4-yloxy)ethyl, 3- (tetrahydropyran-4-yloxy)propyl, 2-((2-(pyrrolidin-l-yl)ethyl)carbamoyl)vinyl, 3-((2- (pyrrolidin- 1 -yl)ethyl)carbamoyl)prop-2-en- 1 -yl, 1 -(2-pyrrolidmylethyl)piperidin-4-ylmethyl, l-(3-pyrrolidinylpropyl)piperidin-4-ylmethyl, l-(2-piperidinylethyl)piperidin-4-ylmethyl, l-(3- piρeridinylpropyl)piperidin-4-ylmethyl, 1 -(2-moφholinoethyl)piperidin-4-ylmethyl, 1 -(3 - moφholinopropyl)piperidin-4-ylmethyl, l-(2-thiomoφholinoethyl)piperidin-4-ylmethyl, l-(3- thiomoφholinopropyl)piperidin-4-ylmethyl, 1 -(2-azetidinylethyl)piperidin-4-ylmethyl, 1 -(3- azetidinylpropyl)piperidin-4-ylmethyl, 2-(l -(2-pyrrolidinylethyl)piperidin-4-yl)ethyl, 2-(l -(3- pytτolidinylpiOpyl)piperidin-4-yl)ethyl, 2-(l-(2-piperidinylethyl)piperidin-4-yl)ethyl, 2-(l-(3- piperidinylpropyl)piperidin-4-yl)ethyl, 2-(l -(2-moφholinoethyl)piperidin-4-yl)ethyl, 2-(l -(3- moφholinopropyl)piperidin-4-yl)ethyl, 2-(l-(2-thiomoφholinoethyl)piperidin-4-yl)ethyl, 2- (l-(3-thiomoφholinopropyl)piperidin-4-yl)ethyl, 2-(l-(2-azetidinylethyl)piperidin-4-yl)ethyl, 2-(l-(3-azetidinylpropyl)piperidin-4-yl)ethyl, 3-moφholino-2-hydroxypropyl, (2i?)-3- moφholino-2-hydroxypropyl, (2S)-3-moφholino-2-hydroxypropyl, 3-piperidino-2- hydroxypropyl, (2i?)-3-piperidino-2-hydroxypropyl, (2S)-3-piperidino-2-hydroxypropyl, 3- pyrrohdin- 1 -yl-2-hydroxypropyl, (2i?)-3 -pyrrohdin- 1 -yl-2-hydroxypropyl, (2S)-3 -pyrrohdin- 1 - yl-2-hydroxypropyl, 3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, (2i?)-3-(l-methylpiperazin- 4-yl)-2-hydroxypropyl, (2S)-3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, 3-(N,N- diethylamino)-2-hydroxypropyl, (2i?)-3-(N,N-diethylamino)-2-hydroxypropyl, (2S)-3-(N,N- diethylamino)-2-hydroxypropyl, 3-(isopropylamino)-2-hydroxypropyl, (2R)-3- (isopropylamino)-2-hydroxypropyl, (2S)-3-(isopropylamino)-2-hydroxypropyl, 3-( ,N- diisopropylamino)-2-hydroxypropyl, (2i?)-3-(N,N-diisopropylamino)-2-hydroxypropyl or (2S)-3 -(N,N-diisopropylamino)-2-hydroxypropyl] . hi another aspect R 2 represents ethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, 2- hydroxyethoxy, 3-hydroxypropoxy, 2-methoxyethoxy, 3-methoxypropoxy, 2- (methylsulphinyl)ethoxy, 2-(methylsulphonyl)ethoxy, 2-(ethylsulphinyl)ethoxy, 2- (ethylsulphonyl)ethoxy, 2-(N,N-dimethylsulphamoyl)ethoxy, 2-(N-methylsulphamoyl)ethoxy, 2-sulphamoylethoxy, 2-(methylamino)ethoxy, 3-(methylamino)propoxy, 2- (ethylamino)ethoxy, 3-(ethylamino)propoxy, 2-(N,N-dimethylamino)ethoxy, 3-(N,N- dimethylamino)propoxy, 2-(N,N-diethylamino)ethoxy, 3-(N,N-diethylamino)propoxy, 2-(N- methyl-N-methylsulphonylamino)ethoxy, 3-(N-methyl-N-methylsulphonylamino)propoxy, 2- moφholinoethoxy, 3-moφholinopropoxy, 2-piperidinoethoxy, 3-piperidinopropoxy, 2- (methylpiperidino)ethoxy, 3-(methylpiperidino)proρoxy, 2-(ethylpiperidino)ethoxy, 3- (ethylpiperidino)propoxy, 2-((2-methoxyethyl)piperidino)ethoxy, 3-((2- methoxyethyl)piperidino)propoxy, 2-((2-methylsulphonyl)ethylpiperidino)ethoxy, 3 -((2- methylsulphonyl)ethylpiperidino)propoxy, piperidin-3-ylmethoxy, piperidin-4-ylmethoxy, 2- (piperidin-3-yl)ethoxy, 2-(piperidin-4-yl)ethoxy, 3-(piperidin-3-yl)propoxy, 3-(piperidin-4- yl)propoxy, 2-(piperidin-2-yl)ethoxy, 3-(piperidin-2-yl)propoxy, (l-methylpiperidin-3- yl)methoxy, (l-methylpiperidin-4-yl)methoxy, 2-(4-hydroxypiperidino)ethoxy, 3-(4- hydroxypiperidino)propoxy, (l-cyanomethylpiperidin-3-yl)methoxy, (1- cyanomethylpiperidin-4-yl)methoxy, 2-(methylpiperidin-3-yl)ethoxy, 2-(methylpiperidin-4- yl)ethoxy, 2-(l-cyanomethylpiperidin-3-yl)ethoxy, 2-(l-cyanomethylpiperidin-4-yl)ethoxy, 3- (methylpiperidin-3-yl)propoxy, 3-(methylpiperidin-4-yl)propoxy, 3-(l-cyanomethylpiperidin- 3-yl)propoxy, 3-(l-cyanomethylpiperidin-4-yl)propoxy, 2-(ethylpiperidin-3-yl)ethoxy, 2- (ethylpiperidin-4-yl)ethoxy, 3-(ethylpiperidin-3-yl)propoxy, 3-(ethylpiperidin-4-yl)propoxy, ((2-methoxyethyl)piperidin-3-yl)methoxy, ((2-methoxyethyl)piperidin-4-yl)methoxy, 2-((2- methoxyethyl)piperidin-3-yl)ethoxy, 2-((2-methoxyethyl)piperidin-4-yl)ethoxy, 3-((2- methoxyethyl)piperidin-3-yl)propoxy, 3-((2-methoxyethyl)piperidin-4-yl)propoxy, (l-(2- methylsulphonylethyl)piperidin-3-yl)methoxy, (l-(2-methylsulphonylethyl)piperidin-4- yl)methoxy, 2-((2-methylsulphonylethyl)piperidin-3 -yl)ethoxy, 2-((2- methylsulphonylethyl)piperidin-4-yl)ethoxy, 3-((2-methylsulphonylethyl)piperidin-3- yl)propoxy, 3-((2-methylsulphonylethyl)piperidin-4-yl)propoxy, l-isopropylpiperidin-2- ylmethoxy, l-isopropylpiperidin-3-ylmethoxy, l-isopropylpiperidin-4-ylmethoxy, 2-(l- isopropylpiperidin-2-yl)ethoxy, 2-(l -isopropylpiperidin-3-yl)ethoxy, 2-(l -isopropylpiperidin- 4-yl)ethoxy, 3-(l-isopropylpiperidin-2-yl)propoxy, 3-(l-isopropylpiperidin-3-yl)propoxy, 3- (l-isopropylpiperidin-4-yl)propoxy, 2-(piperidin-4-yloxy)ethoxy, 3-(piperidin-4- yloxy)propoxy, 2-(l-(cyanomethyl)piperidin-4-yloxy)ethoxy, 3-(l-(cyanomethyl)piperidin-4- yloxy)propoxy, 2-(l-(2-cyanoethyl)ρiperidin-4-yloxy)ethoxy, 3-(l-(2-cyanoethyl)piperidin-4- yloxy)propoxy, 2-(piperazin-l-yl)ethoxy, 3-(piperazin-l-yl)propoxy, (pyrrolidin-2- yl)methoxy, 2-(pyrrolidin-l-yl)ethoxy, 3-(pyrrolidin-l-yl)propoxy, (2-oxo-tetrahydro-2H- pyπolidin-5-yl)methoxy, 5(i?)-(2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methoxy, (5S)-(2-oxo- tetrahydro-2H-pyrrolidin-5-yl)methoxy, (1 ,3-dioxolan-2-yl)methoxy, 2-(l ,3-dioxolan-2- yl)ethoxy, 2-(2-methoxyethylamino)ethoxy, 2-Qi-(2-methoxyethyl)-N-methylamino)ethoxy, 2-(2-hydroxyethylamino)ethoxy, 3-(2-methoxyethylamino)propoxy, 3-(N-(2-methoxyethyl)- N-methylamino)ρropoxy, 3-(2-hydroxyethylamino)propoxy, 2-(l,2,3-triazol-l-yl)ethoxy, 2- (l,2,3-triazol-2-yl)ethoxy, 2-(l,2,4-triazol-l-yl)ethoxy, 2-(l,2,4-triazol-4-yl)ethoxy, 4- pyridylmethyl, 2-(4-pyridyl)ethyl, 4-pyridylmethoxy, 2-(4-pyridyl)ethoxy, 3-(4- pyridyl)propoxy, 3-pyridylmethoxy, 2-(3-pyridyl)ethoxy, 3-(3-pyridyl)propoxy, 2-(4- pyridyloxy)ethoxy, 2-(4-pyridylamino)ethoxy, 2-(4-oxo-l,4-dihydro-l-pyridyl)ethoxy, 2-(2- oxo-imidazolidin-l-yl)ethoxy, 3-(2-oxo-imidazolidin-l-yl)propoxy, 2-thiomoφholinoethoxy, 3 -thiomoφholinopropoxy, 2-(l , 1 -dioxothiomoφholino)ethoxy, 3 -( 1 , 1 - dioxothiomoφholino)propoxy, 2-(2-methoxyethoxy)ethoxy, 2-(4-methylpiperazin- 1 - yl)ethoxy, 3-(4-methylpiperazin-l-yl)propoxy, 2-(4-cyanomethylpiperazin-l-yl)ethoxy, 3-(4- cyanomethylpiperazin- 1 -yl)propoxy, 2-(4-acetylpiperazin- 1 -yl)ethoxy, 3-(4-acetylpiperazin- 1 - yl)propoxy, 2-(4-methylsulphonylpiperazin-l-yl)ethoxy, 3-(4-methylsulphonylpiperazin-l- yl)propoxy, 3-(methylsulphinyl)propoxy, 3-(methylsulphonyl)propoxy, 3- (ethylsulphinyl)propoxy, 3-(ethylsulphonyl)propoxy, 2-(5-methyl-l,2,4-triazol-l-yl)ethoxy, 2- ((N-(3-moφholinopropylsulphonyl)-N-methyl)amino)ethoxy, 2-((N-methyl-N-4- pyridyl)amino)ethoxy, 3-(4-oxidomoφholino)propoxy, 2-(2-(4-methylpiperazin- 1 - yl)ethoxy)ethoxy, 3-(2-(4-methylpiperazin-l-yl)ethoxy)propoxy, 2-(2- moφholinoethoxy)ethoxy, 3-(2-moφholinoethoxy)propoxy, 2-(tetrahydropyran-4- yloxy)ethoxy, 3-(tetrahydropyran-4-yloxy)propoxy, 2-((2-(pyrrolidin-l- yl)ethyl)carbamoyl)vinyl, 3-((2-(pyrrolidin- 1 -yl)ethyl)carbamoyl)prop-2-en- 1 -yloxy, 1 -(2- pyrrolidinylethyl)piperidin-4-ylmethoxy, 1 -(3 -pyrrolidinylpropyl)piperidin-4-ylmethoxy, 1 -(2- piperidinylethyl)piperidin-4-ylmethoxy, l-(3-piperidinylpropyl)piperidin-4-ylmethoxy, l-(2- moφholinoethyl)ρiperidin-4-ylmethoxy, l-(3-moφholinopropyl)piperidin-4-ylmethoxy, l-(2- thiomoφholinoethyl)piperidin-4-ylmethoxy, l-(3-thiomoφholinopropyl)piperidin-4- ylmethoxy, l-(2-azetidinylethyl)piperidin-4-ylmethoxy, l-(3-azetidinylpropyl)piperidin-4- ylmethoxy, 2-(l-(2-pyrrolidinylethyl)piperidin-4-yl)ethoxy, 2-(l-(3- pyrrolidinylpropyl)piperidin-4-yl)ethoxy, 2-(l-(2-piperidinylethyl)piperidin-4-yl)ethoxy, 2-(l- (3-piperidinylpropyl)piperidin-4-yl)ethoxy, 2-(l-(2-moφholinoethyl)piperidin-4-yl)ethoxy, 2- (l-(3-moφholinopropyl)piperidin-4-yl)ethoxy, 2-(l-(2-thiomoφholinoethyl)piperidin-4- yl)ethoxy, 2-(l -(3-thiomoφholinopropyl)piperidin-4-yl)ethoxy, 2-(l -(2- azetidinylethyl)piperidin-4-yl)ethoxy, 2-(l -(3-azetidinylpropyl)piperidin-4-yl)ethoxy, 3- moφholino-2-hydroxypropoxy, (2i?)-3-moφholino-2-hydroxypropoxy, (2S)-3-moφholino-2- hydroxypropoxy, 3-piperidino-2-hydroxypropoxy, (2i?)-3-piperidino-2-hydroxypropoxy, (2S)- 3 -piperidino-2-hydroxypropoxy, 3 -pyrrohdin- 1 -yl-2-hydroxypropoxy, (2R)-3 -pyrrohdin- 1 -yl- 2-hydroxypropoxy, (2S)-3-pyrrolidin-l-yl-2-hydroxypropoxy, 3-(l-methylpiperazin-4-yl)-2- hydroxypropoxy, (2i?)-3-(l-methylpiperazin-4-yl)-2-hydroxypropoxy, (2S)-3-(l- methylpiperazin-4-yl)-2-hydroxypropoxy, 3-(N,N-diethylamino)-2-hydroxypropoxy, (2R)-3- (N,N-diethylamino)-2-hydrOxypropoxy, (2S)-3-(N,N-diethylamino)-2-hydroxypropoxy, 3- (isoproρylamino)-2-hydroxypropoxy, (2i?)-3-(isopropylamino)-2-hydroxypropoxy, (2S)-3- (isopropylamino)-2-hydroxypropoxy, 3-(N,N-diisopropylamino)-2-hydroxypropoxy, (2i?)-3- (N,N-diisopropylamino)-2-hydroxypropoxy or (2S)-3 -(N,N-diisopropylamino)-2- hydroxypropoxy. According to another aspect ofthe present invention conveniently R 2 represents hydroxy, halogeno, cyano, nitro, trifluoromethyl, C_. 3 alkyl, amino or R^ 1 - [wherein X 1 is as hereinbefore defined and R 5 is selected from one ofthe following twenty-two groups: 1) oxiranylC 1-4 alkyl or d-salkyl which may be unsubstituted or which may be substituted with one or more groups selected from fluoro, chloro and bromo, or d-salkyl which may be unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) C 2-3 alkylX 2 C(O)R 11 (wherein X 2 is as hereinbefore defined and R u represents C 1-3 alkyl, - NR 13 R 14 or -OR 15 (wherein R 13 , R 14 and R 15 which may be the same or different are each d_ 4 alkyl or C 1-2 alkoxyethyl)); 3) C - 4 alkylX 3 R 16 (wherein X 3 is as hereinbefore defined and R 16 represents hydrogen, d- 3 alkyl, cyclopentyl, cyclohexyl or a 4-, 5- or 6-membered saturated heterocyclic group with 1- 2 heteroatoms, selected independently from O, S and N, which Cι -3 alkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and d . . 3 alkoxy and which cyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C cyanoalkyl, d- 4 alkyl, C_- 4 hydroxyalkyl, C 1- alkoxy, d. 4 alkoxyCι_ 4 alkyl, C 1-4 alkylsulphonylCι- 4 alkyl, Ci. 4 alkoxycarbonyl, Cι -4 alkylamino, di(C 1-4 alkyl)amino, C 1-4 alkylaminoC 1 - 4 alkyl, di(C_. 4 alkyl)aminoC 1-4 alkyl, di(C 1-4 alkyl)aminoC 1-4 alkoxy and a group - (-O-){(Cι- 4 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from dialkyl)); 4) C 2 - 3 alkylX 4 C 2 _ 3 alkylX 5 R 22 (wherein X 4 and X 5 are as hereinbefore defined and R 22 represents hydrogen or Cι- 3 alkyl); 5) R 28 (wherein R 28 is as defined hereinbefore); 6) Cι-5alkylR 56 (wherein R 56 is a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which heterocyclic group is linked to d- 5 alkyl through a carbon atom and which heterocyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Cι- 4 cyanoalkyl, C_- 4 alkyl, C 1-4 hydroxyalkyl, d- 4 alkoxy, C 1-4 alkoxyd- 4 alkyl, C 1-4 alkylsulphonyld- 4 alkyl, C_- 4 alkoxycarbonyl, d- 4 alkylamino, di(Cι- 4 alkyl)amino, C 1-4 alkylaminoC 1-4 alkyl, di(d- 4 alkyl)aminoC 1-4 alkyl, Ci- 4 alkylaminoC 1- alkoxy, di(C 1-4 alkyl)aminoC 1-4 alkoxy and a group -(-O-) f (C 1 - 4 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C 1- alkyl)) or d-salkylR 57 (wherein R 57 is a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, of which one is N and the other may be selected independently from O, S and N, which heterocyclic group is linked to C 2 - 5 alkyl through a nitrogen atom and which heterocyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Cι- 4 cyanoalkyl, C 1-4 alkyl, d. 4 hydroxyalkyl, C \ . 4 alkoxy, C 1-4 alkoxyC 1-4 alkyl, C 1-4 alkylsulphonylC 1 - 4 alkyl, d- 4 alkoxycarbonyl, d- 4 alkylamino, di(Cι- 4 alkyl)amino, C 1-4 alkylaminoC 1-4 alkyl, di(C 1 . 4 alkyl)aminoC 1-4 alkyl, d- 4 alkylaminoC 1- alkoxy, di(C 1-4 alkyl)aminoCι- 4 alkoxy and a group -(-O-) f (C 1-4 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from Cι -4 alkyl)); 7) C 3-4 alkenylR 58 (wherein R 58 represents R 56 or R 57 as defined hereinbefore); 8) C 3-4 alkynylR 58 (wherein R 58 represents R 56 or R 57 as defined hereinbefore); 9) R 29 (wherein R 29 is as defined hereinbefore); 10) Cι -5 alkylR 29 (wherein R 29 is as defined hereinbefore); 11) C 3-5 alkenylR 29 (wherein R 29 is as defined hereinbefore); 12) C 3 - 5 alkynylR 29 (wherein R 29 is as defined hereinbefore); 13) d- 5 alkylX 6 R 29 (wherein X 6 and R 29 are as defined hereinbefore); 14) C -5 alkenylX 7 R 29 (wherein X 7 and R 29 are as defined hereinbefore); 15) C 4-5 alkynylX 8 R 29 (wherein X 8 and R 29 are as defined hereinbefore); 16) C 2 - 3 alkylX 9 C 1-3 alkylR 29 (wherein X 9 and R 29 are as defined hereinbefore); 17) C 2 - 3 allcylX 9 Cι. 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 18) C -5alkenyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, d_ alkylamino, N,N-di(C 1- alkyl)amino, aminosulphonyl, N-C_. 4 alkylaminosulphonyl and N,N-di(C 1 . 4 alkyl)aminosulphonyl; 19) C -5 alkynyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, C 1- alkylamino, N,N-di(C 1 . 4 alkyl)amino, aminosulphonyl, N-C 1 - 4 alkylaminosulphonyl and N,N-di(C 1 - 4 alkyl)aminosulphonyl; 20) C 2 . 5 alkenylX 9 Cι- 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 21) C 2-5 alkynylX 9 Ci- 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); and 22) Cι. 3 alkylR 54 (Cι- 3 alkyl) q (X 9 ) r R 55 (wherein X 9 , q, r, R 54 and R 55 are as defined hereinbefore); and additionally wherein any Cι- 5 alkyl, C 2 . 5 alkenyl or d-salkynyl group in R 5 X ! - may bear one or more substituents selected from hydroxy, halogeno and amino]. According to another aspect ofthe present invention advantageously R 2 represents hydroxy, halogeno, cyano, nitro, trifluoromethyl, d- 3 alkyl, amino or R 5 X ! - [wherein X 1 is as hereinbefore defined and R 5 is selected from one ofthe following twenty-two groups: 1) Cι -4 alkyl which may be unsubstituted or which may be substituted with one or more groups selected from fluoro, chloro and bromo, or d-salkyl which may be unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) C 2-3 alkylX 2 C(O)R π (wherein X 2 is as hereinbefore defined and R π represents -NR 13 R 14 or -OR 15 (wherein R 13 , R 14 and R 15 which may be the same or different are each Cι. 4 alkyl or C \ . 2 alkoxyethyl)); 3) C 2-4 alkylX 3 R 16 (wherein X 3 is as hereinbefore defined and R 16 is a group selected from d- 3 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl and tetrahydropyranyl, which Cι- 3 alkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and d- 2 a_koxy and which cyclopentyl, cyclohexyl, pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl or tetrahydropyranyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Cι- 3 cyanoalkyl, d- 3 alkyl, d_ 3 hydroxyalkyl, d- 3 alkoxy, d -2 alkoxyCι -3 alkyl, C 1-2 alkylsulphonylCι. 3 alkyl, d- 3 alkoxycarbonyl, Cι.3alkylamino, di(C_- 3 alkyl)amino, d-salkylaminod^alkyl, di(Cι- 3 alkyl)aminoCι -3 alkyl, Cι -3 alkylaminoCι -3 alkoxy, di(C 1 . 3 alkyl)aminoCι- 3 alkoxy and a group - (-O-) f (Ci- 3 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, moφholino and thiomoφholino, which cyclic group may bear one or more substituents selected from Ci- 3 alkyl)); 4) C 2 - 3 alkylX 4 C 2 - 3 alkylX 5 R 22 (wherein X 4 and X 5 are as hereinbefore defined and R 22 represents hydrogen or Cι- 3 alkyl); 5 5) R 28 (wherein R 2S is as defined hereinbefore); 6) C 1-4 alkylR 59 (wherein R 59 is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidin-1-yl, azetidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and 1,3- dithian-2-yl, which group is linked to C 1-4 alkyl through a carbon atom and which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Ci -3 cyanoalkyl, C_- 10 3 alkyl, Cι- 3 hydroxyalkyl, d_3alkoxy, Ci-α lkoxyd-salkyl, d_ 2 alkylsulphonyld. 3 alkyl, d- 3 alkoxycarbonyl, d- 3 alkylamino, di(Cι- 3 alkyl)amino, Cι- 3 alkylaminoCi. 3 alkyl, di(Cι- 3 alkyl)aminoCi. 3 alkyl, Cι- alkylaminoCi- 3 alkoxy, di(Cι- 3 alkyl)aminod. 3 alkoxy and a group - (-O-) f (C_- 3 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, moφholino and 15 thiomoφholino, which cyclic group may bear one or more substituents selected from C_. 3 alkyl)) or C 2-4 alkylR 60 (wherein R 60 is a group selected from moφholino, thiomoφholino, azetidin-1-yl, pyrrolidin-1-yl, piperazin-1-yl and piperidino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Cι_ 3 cyanoalkyl, C_ -3 alkyl, d_ 3 hydroxyalkyl, Cι_ 3 alkoxy, d- 2 alkoxyC 1-3 alkyl, Ci -2 alkylsulphonyld- 3 alkyl, d- 20 3 alkoxycarbonyl, C_- alkylamino, di(d- 3 alkyl)amino, d-salkylaminod-salkyl, di(C 1 . 3 alkyl)aminoCι- 3 alkyl, Cι_ 3 alkylaminoCι- 3 alkoxy, di(d- 3 alkyl)aminod- 3 alkoxy and a group - (-O-) f (Cι- 3 a_kyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, piperazinyl, piperidinyl, imidazolidinyl, azetidinyl, moφholino and thiomoφholino, which cyclic group may bear one or more substituents selected from d- 25 3 alkyl)); 7) C 3 - 4 alkenylR 61 (wherein R 61 represents R 59 or R 60 as defined hereinbefore); 8) C 3-4 alkynylR 61 (wherein R 61 represents R 59 or R 60 as defined hereinbefore); 9) R 29 (wherein R 29 is as defined hereinbefore); 10) C 1-4 alkylR 29 (wherein R 29 is as defined hereinbefore); 30 11) l-R 29 prop-l-en-3-yl or l-R 29 but-2-en-4-yl (wherein R 29 is as defined hereinbefore with the proviso that when R 5 is l-R 29 prop-l-en-3-yl, R 29 is linked to the alkenyl group via a carbon atom); 12) l-R 29 prop-l-yn-3-yl or l-R 29 but-2-yn-4-yl (wherein R 29 is as defined hereinbefore with the proviso that when R 5 is l-R 29 ρrop-l-yn-3-yl, R 29 is linked to the alkynyl group via a carbon atom); 13) d-salkylX R (wherein X and R are as defined hereinbefore); 14) l-(R 29 X 7 )but-2-en-4-yl (wherein X 7 and R 29 are as defined hereinbefore); 15) l-(R 29 X 8 )but-2-yn-4-yl (wherein X 8 and R 29 are as defined hereinbefore); 16) C 2 . 3 alkylX 9 Cι- 3 alky_R 29 (wherein X 9 and R 29 are as defined hereinbefore); 17) d- 3 alkylX 9 Cι. 3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 18) C 2 - 5 alkenyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, d- 4 alkylamino, N,N-di(d- 4 alkyl)amino, aminosulphonyl, N-d- 4 alkylaminosulphonyl and N,N- di(C_- 4 alkyl)aminosulρhonyl; 19) C -5 alkynyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, Ci- 4 alkylamino, N,N-di(Cι- alkyl)amino, aminosulphonyl, N-C 1-4 alkylaminosulphonyl and N,N- di(C 1-4 alkyl)aminosulphonyl; 20) C -4 alkenylX 9 C_ -3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 21) C 2 . 4 alkynylX C_- 3 alkylR (wherein X and R are as defined hereinbefore); and 22) C 1-3 alkylR 54 (C 1 - 3 alkyl) q (X 9 ) r R 55 (wherein X 9 , q, r, R 54 and R 55 are as defined hereinbefore); and additionally wherein any Ci-salkyl, C 2 -salkenyl or C 2-5 alkynyl group in R^ 1 - may bear one or more substituents selected from hydroxy, halogeno and amino]. According to another aspect ofthe present invention preferably R 2 represents hydroxy, halogeno, nitro, trifluoromethyl, Cι- 3 alkyl, cyano, amino or R 5 X 1 - [wherein X 1 is as hereinbefore defined and R 5 is selected from one ofthe following twenty groups: 1) d- 3 alkyl which may be unsubstituted or which may be substituted with one or more groups selected from fluoro, chloro and bromo, or C 2 -3alkyl which maybe unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) 2-(3,3-dimethylureido)ethyl, 3-(3,3-dimethylureido)propyl, 2-(3-methylureido)ethyl, 3-(3- methylureido)propyl, 2-ureidoethyl, 3-ureidoproρyl, 2-(N,N-dimethylcarbamoyloxy)ethyl, 3- (N,N-dimethylcarbamoyloxy)propyl, 2-(N-methylcarbamoyloxy)ethyl, 3-(N- methylcarbamoyloxy)proρyl, 2-(carbamoyloxy)ethyl, 3-(carbamoyloxy)propyl, or 2-(N- methyl-N-(butoxycarbonyl)amino)ethyl; 3) C 2 -3alkylX 3 R 16 (wherein X 3 is as hereinbefore defined and R 16 is a group selected from d- 3 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl, piperidinyl, piperazinyl, azetidinyl, imidazolidinyl and tetrahydropyranyl which group is linked to X 3 through a carbon atom and which Cι- 3 alkyl group may bear 1 or 2 substituents selected from hydroxy, halogeno and d- 2 alkoxy and which cyclopentyl, cyclohexyl, pyrrolidinyl, piperidinyl, piperazinyl, azetidinyl, imidazolidinyl or tetrahydropyranyl group may bear one substituent selected from oxo, hydroxy, halogeno, cyano, Cι -2 cyanoalkyl, Cι -2 alkyl, Cι. 2 hydroxyalkyl, Cι- 2 alkoxy, C \ . 2alkoxyd-3alkyl, Cι- 2 alkylsulphonylCι- 3 alkyl, Cι_ 2 alkoxycarbonyl, di(Cι- 3 alkyl)amino, d-salkylaminod-salkyl, di(Cι -3 alkyl)aminoC 1 - 3 alkyl, d-3alkylaminoC_- 3 alkoxy, di(C 1-3 alkyl)aminoC 1- 3alkoxy and a group -(-O-)_(d-3alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino)); 4) C 2-3 alkylX 4 C 2 - 3 alkylX 5 R 22 (wherein X 4 and X 5 are as hereinbefore defined and R 22 represents hydrogen or Cι -2 alkyl); 5) R 28 (wherein R 28 is as defined hereinbefore); 6) C_- 3 alkylR 59 (wherein R 59 is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, imidazolidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and 1,3- dithian-2-yl, which group is linked to C__ 3 alkyl through a carbon atom and which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, Cι- 2 cyanoalkyl, C_- alkyl, Cι- 2 hydroxyalkyl, Cι- alkoxy, C 1-2 alkoxyCι_ alkyl, Cι -2 alkylsulphonyld. 3 alkyl, C_- 2 alkoxycarbonyl, Cι- 3 alkylamino, di(Cι. 3 alkyl)amino, C_- 3 alkylaminod- 3 alkyl, di(d_ 3 alkyl)aminoCι. 3 alkyl, Cι -3 alkylaminoCι-3alkoxy, di(C 1-3 aikyl)aminoCι- 3 alkoxy and a group - (-O-) f (Cι-3alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino)) or C 2 - 3 alkylR 60 (wherein R 60 is a group selected from moφholino, thiomoφholino, azetidin-1-yl, pyrrohdin- 1-yl, piperazin-1-yl and piperidino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1 -2cyanoalkyl, Ci- 2 alkyl, Cι_ 2 hydroxyalkyl, Cι- 2 alkoxy, C 1 - 2 alkoxyCι- 3 alkyl, d. 2 alkylsulphonylC 1-3 alkyl, d- 2 alkoxycarbonyl, C 1 . 3 alkylamino, di(d- alkyl)amino, C 1-3 alkylaminod-3alkyl, di(C_- 3 alkyl)aminoCι- 3 alkyl, d-sal ylaminod-salkoxy, di(C_- a_kyl)aminoC_-3alkoxy and a group - (-O-) f (C 1 - 3 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino)) ; 7) R 29 (wherein R 2 is as defined hereinbefore); 8) d. 4 alkylR 29 (wherein R 29 is as defined hereinbefore); 9) l-R 29 but-2-en-4-yl (wherein R 29 is as defined hereinbefore); 10) l-R 29 but-2-yn-4-yl (wherein R 29 is as defined hereinbefore); 11) C 1-3 alkylX 6 R 29 (wherein X 6 and R 29 are as defined hereinbefore); 12) l-(R 29 X 7 )but-2-en-4-yl (wherein X 7 and R 29 are as defined hereinbefore); 13) 1 -(R 29 X 8 )but-2-yn-4-yl (wherein X 8 and R 29 are as defined hereinbefore); 14) C 2 . 3 alkylX 9 C 1-3 alkylR 29 (wherein X 9 and R 29 are as defined hereinbefore); 15) C 2-3 alkylX 9 C 1-3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 16) C - 5 alkenyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, d- 4 alkylamino, N,N-di(Cι- 4 alkyl)amino, aminosulphonyl, N-C 1-4 alkylaminosulphonyl and N,N- di(d -4 alkyl)aminosulphonyl; 17) C 2-5 alkynyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, C__ 4 alkylamino, N . N-di(Cι- 4 alkyl)amino, aminosulphonyl, N-d. 4 a_kylaminosulphonyl and N,N- di(Cι -4 alkyl)aminosulphonyl; 18) C 2 - 3 alkenylX 9 C 1-3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); 19) C 2 - 3 alkynylX 9 Cι -3 alkylR 28 (wherein X 9 and R 28 are as defined hereinbefore); and 20) Cι- 3 alkylR 54 (Cι -3 alkyl) q (X 9 ) r R 55 (wherein X 9 , q, r, R 54 and R 55 are as defined hereinbefore); and additionally wherein any d-salkyl, C 2 _salkenyl or C 2 -salkynyl group in R 5 X ! - may bear one or more substituents selected from hydroxy, halogeno and amino]. According to another aspect ofthe present invention more preferably R 2 represents hydroxy, d_ 3 alkyl, amino or R 5 X 1 - [wherein X 1 is as hereinbefore defined and R 5 represents methyl, ethyl, benzyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-methoxyethyl, 3-methoxypropyl, 2-(methylsulphinyl)ethyl, 2-(methylsulphonyl)ethyl, 2- (ethylsulphinyl)ethyl, 2-(ethylsulphonyl)ethyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N- methylsulphamoyl)ethyl, 2-sulphamoylethyl, 2-(methylamino)ethyl, 3-(methylamino)propyl, 2-(ethylamino)ethyl, 3-(ethylamino)propyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N- dimethylamino)propyl, 2-(N,N-diethylamino)ethyl, 3-(N,N-diethylamino)propyl, 2-(N-methyl- N-methylsulphonylamino)ethyl, 3-(N-methyl-N-methylsulphonylamino)propyl, 2- moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2- (methylpiperidino)ethyl, 3-(methylpiperidino)propyl, 2-(ethylpiperidino)ethyl, 3- (ethylpiperidino)propyl, 2-((2-methoxyethyl)piperidino)ethyl, 3-((2- methoxyethyl)piperidino)propyl, 2-((2-methylsulphonyl)ethylpiperidino)ethyl, 3-((2- methylsulphonyl)ethylpiperidino)propyl, piperidin-3-ylmethyl, piperidin-4-ylmethyl, 2- (piperidin-3-yl)ethyl, 2-(piperidin-4-yl)ethyl, 3-(piperidin-3-yl)propyl, 3-(piperidin-4- yl)ρropyl, 2-(piperidin-2-yl)ethyl, 3-(piperidin-2-yl)propyl, (l-methylpiperidin-3-yl)methyl, (l-methylpiperidin-4-yl)methyl, (l-cyanomethylpiperidin-3-yl)methyl, (1- cyanomethylpiperidin-4-yl)methyl, 2-(methylpiperidin-3-yl)ethyl, 2-(methylpiperidin-4- yl)ethyl, 2-(l-cyanomethylpiperidin-3-yl)ethyl, 2-(l-cyanomethylpiperidin-4-yl)ethyl, 3- (methylpiperidin-3-yl)propyl, 3-(methylpiperidin-4-yl)propyl, 3-(l-cyanomethylpiperidin-3- yl)propyl, 3-(l-cyanomethylpiperidin-4-yl)propyl, 2-(ethylpiperidin-3-yl)ethyl, 2- (ethylpiperidin-4-yl)ethyl, 3-(ethylpiperidin-3-yl)propyl, 3-(ethylpiperidin-4-yl)propyl, ((2- methoxyethyl)piperidin-3-yl)methyl, ((2-methoxyethyl)piperidin-4-yl)methyl, 2-((2- methoxyethyl)piperidin-3-yl)ethyl, 2-((2-methoxyethyl)piperidin-4-yl)ethyl, 3-((2- methoxyethyl)piperidin-3-yl)propyl, 3-((2-methoxyethyl)piperidin-4-yl)propyl, (1 -(2- methylsulphonylethyl)piperidin-3-yl)methyl, (l-(2-methylsulphonylethyl)piperidin-4- yl)methyl, 2-((2-methylsulphonylethyl)piperidin-3-yl)ethyl, 2-((2- methylsulphonylethyl)piperidin-4-yl)ethyl, 3-((2-methylsulphonylethyl)piperidin-3-yl)propyl, 3-((2-methylsulphonylethyl)piperidin-4-yl)propyl, l-isopropylpiperidin-2-ylmethyl, 1- isopropylpiperidin-3-ylmethyl, l-isopropylpiperidin-4-ylmethyl, 2-(l-isopropylpiperidin-2- yl)ethyl, 2-(l-isopropylpiperidin-3-yl)ethyl, 2-(l-isopropylpiperidin-4-yl)ethyl, 3-(l- isopropylpiρeridin-2-yl)propyl, 3-(l-isopropylpiperidin-3-yl)propyl, 3-(l-isopropylpiperidin- 4-yl)propyl, 2-(piperidin-4-yloxy)ethyl, 3-(piperidin-4-yloxy)propyl, 2-(l- (cyanomethyl)piperidin-4-yloxy)ethyl, 3-(l-(cyanomethyl)piperidin-4-yloxy)propyl, 2-(l-(2- cyanoethyl)piρeridin-4-yloxy)ethyl, 3-(l -(2-cyanoethyl)piperidin-4-yloxy)propyl, 2- (ρiperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, (pyπolidin-2-yl)methyl, 2-(pyrrolidin-l- yl)ethyl, 3-(pyrrolidin-l-yl)propyl, (2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methyl, 5(i?)-(2-oxo- tetrahydro-2H-ρyrrolidin-5-yl)methyl, (5S)-(2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(N-(2- methoxyethyl)-N-methylamino)ethyl, 2-(2-hydroxyethylamino)ethyl, 3 -(2- methoxyethylamino)ρropyl, 3-(N-(2-methoxyethyl)-N-methylamino)propyl, 3-(2- hydroxyethylamino)propyl, 2-methylthiazol-4-ylmethyl, 2-acetamidothiazol-4-ylmethyl, 1- methylimidazol-2-ylmethyl, 2-(imidazol-l-yl)ethyl, 2-(2-methylimidazol-l-yl)ethyl, 2-(2- ethylimidazol-l-yl)ethyl, 3-(2-methylimidazol-l-yl)propyl, 3-(2-ethylimidazol-l-yl)propyl, 2- (l,2,3-triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4- triazol-4-yl)ethyl, 4-pyridylmethyl, 2-(4-pyridyl)ethyl, 3-(4-pyridyl)propyl, 2-(4- pyridyloxy)ethyl, 2-(4-pyridylamino)ethyl, 2-(4-oxo-l,4-dihydro-l-pyridyl)ethyl, 2-(2-oxo- imidazolidin-l-yl)ethyl, 3-(2-oxo-imidazolidin-l-yl)propyl, 2-thiomoφholinoethyl, 3- thiomoφholinopropyl, 2-(l , 1 -dioxothiomoφholino)ethyl, 3-(l , 1 -dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin-l-yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3-(methylsulphonyl)propyl, 3-(ethylsulphinyl)propyl, 3- (ethylsulphonyl)propyl, 2-(5-methyl-l,2,4-triazol-l-yl)ethyl, moφholino, 2-((N-(l- methylimidazol-4-ylsulphonyl)-N-methyl)amino)ethyl, 2-((N-(3 -moφholinopropylsulphonyl)- N-methyl)amino)ethyl, 2-((N-methyl-N-4-pyridyl)amino)ethyl, 3-(4-oxidomoφholino)propyl, 2-(2-(4-methylpiperazin- 1 -yl)ethoxy)ethyl, 3 -(2-(4-methylpiperazin- 1 -yl)ethoxy)propyl, 2-(2- moφholinoethoxy)ethyl, 3-(2-moφholinoethoxy)propyl, 2-(tetrahydropyran-4-yloxy)ethyl, 3- (tetrahydropyran-4-yloxy)propyl, 2-((2-(pyrrolidin- 1 -yl)ethyl)carbamoyl)vinyl, 3 -((2- (pyrrohdin- 1 -yl)ethyl)carbamoyl)prop-2-en- 1 -yl, 1 -(2-pyrrolidinylethyl)piperidin-4-yhnethyl, 1 -(3 -pyrrolidinylpropyl)piperidin-4-ylmethyl, 1 -(2-piperidinylethyl)piperidin-4-ylmethyl, 1 -(3- piperidinylpropyl)piperidin-4-ylmethyl, 1 -(2-moφholinoethyl)piperidin-4-ylmethyl, 1 -(3 - moφholinopropyl)piperidin-4-ylmethyl, 1 -(2-thiomoφholinoethyl)piperidin-4-ylmethyl, 1 -(3- thiomoφholinopropyl)piperidin-4-ylmethyl, l-(2-azetidinylethyl)piperidin-4-ylmethyl or l-(3- azetidinylpropyl)piperidin-4-ylmethyl, 3-moφholino-2-hydroxypropyl, (2i?)-3-moφholino-2- hydroxypropyl, (2S)-3-moφholino-2-hydroxypropyl, 3-piperidino-2-hydroxypropyl, (2i?)-3- piperidino-2-hydroxypropyl, (2S)-3-piperidino-2-hydroxypropyl, 3-pyrrolidin- 1 -yl-2- hydroxypropyl, (2R)-3 -pyrrohdin- 1 -yl-2-hydroxypropyl, (2S)-3 -pyrrohdin- 1 -yl-2- hydroxypropyl, 3 -( 1 -methylpiperazin-4-yl)-2-hydroxypropyl, (2R)-3 -( 1 -methylpiperazin-4-yl)- 2-hydroxypropyl, (2S)-3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, 3-(N,N-diethylamino)-2- hydroxypropyl, (2i?)-3-(N,N-diethylamino)-2-hydroxypropyl, (2S)-3-Q^,N-diethylamino)-2- hydroxypropyl, 3-(isopropylamino)-2-hydroxypropyl, (2i?)-3-(isopropylamino)-2- hydroxypropyl, (2S)-3-(isopropylamino)-2-hydroxypropyl, 3-(N,N-diisopropylamino)-2- hydroxypropyl, (2i?)-3-(N,N-diisopropylamino)-2-hydroxypropyl or (2S)-3-(N,N- diisopropylamino)-2-hydroxypropyl]. According to another aspect ofthe present invention particularly R 2 represents C_. _r -1 1 c alkyl, amino or R X - [wherein X is as hereinbefore defined and R represents ethyl, benzyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-methoxyethyl, 3- methoxypropyl, 2-(methylsulphinyl)ethyl, 2-(methylsulphonyl)ethyl, 2-(ethylsulphinyl)ethyl, 2-(ethylsulphonyl)ethyl, 2-Qi,N-dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, 2- sulphamoylethyl, 2-(methylamino)ethyl, 3-(methylamino)propyl, 2-(ethylamino)ethyl, 3- (ethylamino)propyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-(N,N- diethylamino)ethyl, 3-Q^,N-diethylamino)propyl, 2-(N-methyl-N- methylsulphonylamino)ethyl, 3 -(N-methyl-N-methylsulphonylamino)propyl, 2- moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2- (methylpiperidino)ethyl, 3-(methylρiperidino)propyl, 2-(ethylpiperidino)ethyl, 3- (ethylpiρeridino)propyl, 2-((2-methoxyethyl)piperidino)ethyl, 3-((2- methoxyethyl)piperidino)propyl, 2-((2-methylsulphonyl)ethylpiperidino)ethyl, 3-((2- methylsulphonyl)ethylpiperidino)propyl, piperidin-3-ylmethyl, piperidin-4-ylmethyl, 2- (piperidin-3-yl)ethyl, 2-(piperidin-4-yl)ethyl, 3-(piperidin-3-yl)propyl, 3-(piperidin-4- yl)propyl, 2-(piperidin-2-yl)ethyl, 3-(piperidin-2-yl)propyl, (l-methylpiperidin-3-yl)methyl, (l-methylpiperidin-4-yl)methyl, (l-cyanomethylpiperidin-3-yl)methyl, (1- cyanomethylpiperidin-4-yl)methyl, 2-(methylpiperidin-3-yl)ethyl, 2-(methylpiperidin-4- yl)ethyl, 2-(l-cyanomethylpiperidin-3-yl)ethyl, 2-(l-cyanomethylpiρeridin-4-yl)ethyl, 3- (methylpiperidin-3-yl)propyl, 3-(methylpiperidin-4-yl)propyl, 3-(l-cyanomethylpiperidin-3- yl)propyl, 3-(l-cyanomethylpiperidin-4-yl)propyl, 2-(ethylpiperidin-3-yl)ethyl, 2- (ethylpiperidin-4-yl)ethyl, 3-(ethylpiperidin-3-yl)propyl, 3-(ethylpiperidin-4-yl)propyl, ((2- methoxyethyl)piperidin-3-yl)methyl, ((2-methoxyethyl)piperidin-4-yl)methyl, 2-((2- methoxyethyl)piperidin-3-yl)ethyl, 2-((2-methoxyethyl)piperidin-4-yl)ethyl, 3-((2- methoxyethyl)piperidin-3-yl)propyl, 3-((2-methoxyethyl)piperidin-4-yl)propyl, (l-(2- methylsulphonylethyl)piperidin-3-yl)methyl, (l-(2-methylsulphonylethyl)piperidin-4- yl)methyl, 2-((2-methylsulphonylethyl)piperidin-3-yl)ethyl, 2-((2- methylsulphonylethyl)piperidin-4-yl)ethyl, 3-((2-methylsulphonylethyl)piperidin-3-yl)propyl, 3-((2-methylsulphonylethyl)piperidin-4-yl)propyl, l-isopropylpiρeridin-2-ylmethyl, 1- isopropylpiperidin-3-ylmethyl, l-isopropylpiperidin-4-ylmethyl, 2-(l-isopropylpiperidin-2- yl)ethyl, 2-(l-isopropylpiperidin-3-yl)ethyl, 2-(l-isopropylpiperidin-4-yl)ethyl, 3-(l- isopropylpiperidin-2-yl)propyl, 3-(l-isopropylpiperidin-3-yl)propyl, 3-(l-isopropylpiperidin- 4-yl)propyl, 2-(piperidin-4-yloxy)ethyl, 3-(piperidin-4-yloxy)propyl, 2-(l- (cyanomethyl)piperidin-4-yloxy)ethyl, 3-(l-(cyanomethyl)piperidin-4-yloxy)propyl, 2-(l-(2- cyanoethyl)piperidin-4-yloxy)ethyl, 3-(l -(2-cyanoethyl)piperidin-4-yloxy)propyl, 2- (piperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, (pyrrolidin-2-yl)methyl, 2-(pyrrolidin-l- yl)ethyl, 3-(pyrrolidin-l-yl)propyl, (2-oxo-tetrahydro-2if-pyrrolidin-5-yl)methyl, 5(i?)-(2-oxo- tetrahydro-2H-pyrrolidin-5-yl)methyl, (5S)-(2-oxo-tetrahydro-2H-pyrrohdin-5-yl)methyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(N-(2- methoxyethyl)-N-methylamino)ethyl, 2-(2-hydroxyethylamino)ethyl, 3-(2- methoxyethylamino)propyl, 3-(N-(2-methoxyethyl)-N-methylamino)propyl, 3-(2- hydroxyethylamino)propyl, 2-methylthiazol-4-ylmethyl, 2-acetamidothiazol-4-ylmethyl, 1- methylimidazol-2-ylmethyl, 2-(imidazol-l-yl)ethyl, 2-(2-methylimidazol-l-yl)ethyl, 2-(2- ethylimidazol-l-yl)ethyl, 3-(2-methylimidazol-l-yl)propyl, 3-(2-ethylimidazol-l-yl)propyl, 2- (l,2,3-triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4- triazol-4-yl)ethyl, 4-pyridyhnethyl, 2-(4-pyridyl)ethyl, 3-(4-pyridyl)propyl, 2-(4- pyridyloxy)ethyl, 2-(4-pyridylamino)ethyl, 2-(4-oxo-l,4-dihydro-l-pyridyl)ethyl, 2-(2-oxo- imidazolidin-l-yl)ethyl, 3-(2-oxo-imidazolidin-l-yl)propyl, 2-thiomoφholinoethyl, 3- thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-(l,l-dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin- 1 -yl)ethyl, 3 -(4-methylpiperazin- 1 -yl)propyl, 3-(methylsulphinyl)ρropyl, 3-(methylsulphonyl)propyl, 3-(ethylsulphinyl)propyl, 3- (ethylsulphonyl)propyl, 2-(5-methyl-l,2,4-triazol-l-yl)ethyl, moφholino, 2-((N-(l- methylimidazol-4-ylsulphonyl)-N-methyl)amino)ethyl, 2-((N-(3-moφholinopropylsulphonyl)- N-methyl)amino)ethyl, 2-((N-methyl-N-4-pyridyl)amino)ethyl, 3-(4-oxidomoφholino)propyl, 2-(2-(4-methylpiperazin- 1 -yl)ethoxy)ethyl, 3 -(2-(4-methylpiρerazin-l -yl)ethoxy)propyl, 2-(2- moφholinoethoxy)ethyl, 3-(2-moφholinoethoxy)propyl, 2-(tetrahydropyran-4-yloxy)ethyl, 3- (tetrahydropyran-4-yloxy)propyl, 2-((2-(pyrrolidin-l -yl)ethyl)carbamoyl)vinyl, 3-((2- (pyrrolidin-l-yl)ethyl)carbamoyl)prop-2-en-l-yl, l-(2-pyrrolidinylethyl)piperidin-4-ylmethyl, l-(3-pyrrolidinylpropyl)piperidin-4-ylmethyl, l-(2-piperidinylethyl)piρeridin-4-ylmethyl, l-(3- piperidinylpropyl)piperidin-4-ylmethyl, 1 -(2-moφholinoethyl)piperidin-4-ylmethyl, 1 -(3 - moφholinopropyl)piperidin-4-ylmethyl, 1 -(2-thiomoφholinoethyl)piperidin-4-ylmethyl, 1 -(3- thiomoφholinopropyl)piperidin-4-ylmethyl, l-(2-azetidinylethyl)piperidin-4-ylmethyl or l-(3- azetidinylpropyl)piperidin-4-ylmethyl, 3-moφholino-2-hydroxypropyl, (2R)-3-moφholino-2- hydroxypropyl, (2 -3-moφhohno-2-hydroxypropyl, 3-piperidino-2-hydroxypropyl, (2R)-3- piperidino-2-hydroxypropyl, (2S)-3-piperidino-2-hydroxypropyl, 3 -pyrrohdin- 1 -yl-2- hydroxypropyl, (2i?)-3 -pyrrohdin- l-yl-2-hydroxypropyl, (2S)-3-pyrrolidin-l-yl-2- hydroxypropyl, 3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, (2i?)-3-(l-methylpiperazin-4-yl)- 2-hydroxypropyl, (2S)-3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, 3-(N,N-diethylamino)-2- hydroxypropyl, (2i?)-3-(N,N-diethylamino)-2-hydroxypropyl, (2S)-3-(N,N-diethylamino)-2- hydroxypropyl, 3-(isopropylamino)-2-hydroxypropyl, (2i?)-3-(isopropylamino)-2- hydroxypropyl, (2S)-3-(isopropylamino)-2-hydroxypropyl, 3-(N,N-diisopropylamino)-2- hydroxypropyl, (2i?)-3-(N,N-diisopropylamino)-2-hydroxypropyl or (2S)-3-(N,N- diisopropylamino)-2-hydroxypropyl]. According to another aspect ofthe present invention more particularly R 2 represents C 1-3 alkyl, amino or R^ 1 - [wherein X 1 is as hereinbefore defined and R 5 represents ethyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-methoxyethyl, 3- methoxypropyl, 2-(methylsulphinyl)ethyl, 2-(methylsulphonyl)ethyl, 2-(ethylsulphinyl)ethyl, 2-(ethylsulphonyl)ethyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, 2- sulphamoylethyl, 2-(methylamino)ethyl, 3-(methylamino)propyl, 2-(ethylamino)ethyl, 3- (ethylamino)propyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-(N,N- diethylamino)ethyl, 3-(N,N-diethylamino)propyl, 2-(N-methyl-N- methylsulphonylamino)ethyl, 3-(N-methyl-N-methylsulphonylamino)propyl, 2- moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2- (methylpiperidino)ethyl, 3-(methylpiperidino)propyl, 2-(ethylpiperidino)ethyl, 3- (ethylpiperidino)propyl, 2-((2-methoxyethyl)piperidino)ethyl, 3-((2- methoxyethyl)piperidino)propyl, 2-((2-methylsulphonyl)ethylpiperidino)ethyl, 3-((2- methylsulphonyl)ethylpiperidino)propyl, piperidin-3-ylmethyl, piperidin-4-ylmethyl, 2- (piperidin-3-yl)ethyl, 2-(piperidin-4-yl)ethyl, 3-(piperidin-3-yl)propyl, 3-(piperidin-4- yl)propyl, 2-(piperidin-2-yl)ethyl, 3-(piperidin-2-yl)propyl, (l-methylpiρeridin-3-yl)methyl, (1 -methylpiperidin-4-yl)methyl, (1 -cyanomethylpiperidin-3-yl)methyl, (1 - cyanomethylpiperidin-4-yl)methyl, 2-(methylpiperidin-3-yl)ethyl, 2-(methylpiperidin-4- yl)ethyl, 2-(l-cyanomethylpiperidin-3-yl)ethyl, 2-(l-cyanomethylpiperidin-4-yl)ethyl, 3- (methylpiperidin-3-yl)propyl, 3-(methylpiperidin-4-yl)propyl, 3-(l -cyanomethylpiperidin-3- yl)propyl, 3-(l-cyanomethylρiperidin-4-yl)propyl, 2-(ethylpiperidin-3-yl)ethyl, 2- (ethylpiperidin-4-yl)ethyl, 3-(ethylpiperidin-3-yl)propyl, 3-(ethylpiperidin-4-yl)propyl, ((2- methoxyethyl)piperidin-3-yl)methyl, ((2-methoxyethyl)piperidin-4-yl)methyl, 2-((2- methoxyethyl)piperidin-3-yl)ethyl, 2-((2-methoxyethyl)piperidin-4-yl)ethyl, 3-((2- methoxyethyl)piperidin-3-yl)propyl, 3-((2-methoxyethyl)piperidin-4-yl)propyl, (l-(2- methylsulphonylethyl)piperidin-3-yl)methyl, (l-(2-methylsulphonylethyl)piperidin-4- yl)methyl, 2-((2-methylsulphonylethyl)piperidin-3-yl)ethyl, 2-((2- methylsulphonylethyl)piperidin-4-yl)ethyl, 3-((2-methylsulphonylethyl)piperidin-3-yl)propyl, 3-((2-methylsulphonylethyl)piperidin-4-yl)propyl, l-isopropylpiperidin-2-ylmethyl, 1- isopropylpiperidin-3-ylmethyl, l-isopropylpiperidin-4-ylmethyl, 2-(l-isopropylpiperidin-2- yl)ethyl, 2-(l-isopropylpiperidin-3-yl)ethyl, 2-(l-isopropylpiperidin-4-yl)ethyl, 3-(l- isopropylpiperidin-2-yl)propyl, 3 -( 1 -isopropylpiperidin-3 -yl)propyl, 3 -( 1 -isopropylpiperidin- 4-yl)propyl, 2-(piperidin-4-yloxy)ethyl, 3-(piperidin-4-yloxy)propyl, 2-(l- (cyanomethyl)piperidin-4-yloxy)ethyl, 3-(l-(cyanomethyl)piperidin-4-yloxy)propyl, 2-(l-(2- cyanoethyl)piperidin-4-yloxy)ethyl, 3-(l-(2-cyanoethyl)piperidin-4-yloxy)propyl, 2- (piperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, (pyrrolidin-2-yl)methyl, 2-(pyrrolidin-l- yl)ethyl, 3-(pyrrolidin-l-yl)propyl, (2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methyl, 5(i?)-(2-oxo- tetrahydro-2iJ-pyrrolidin-5-yl)methyl, (5S)-(2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(N-(2- methoxyethyl)-N-methylamino)ethyl, 2-(2-hydroxyethylamino)ethyl, 3-(2- methoxyethylamino)ρropyl, 3-(N-(2-methoxyethyl)-N-methylamino)propyl, 3-(2- hydroxyethylamino)propyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 2-(l,2,4- triazol-l-yl)ethyl, 2-(l,2,4-triazol-4-yl)ethyl, 4-pyridylmethyl, 2-(4-pyridyl)ethyl, 3-(4- pyridyl)propyl, 2-(4-pyridyloxy)ethyl, 2-(4-pyridylamino)ethyl, 2-(4-oxo-l,4-dihydro-l- pyridyl)ethyl, 2-(2-oxo-imidazolidin-l-yl)ethyl, 3-(2-oxo-imidazolidin-l-yl)propyl, 2- thiomoφholinoethyl, 3 -thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-(l,l- dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin-l-yl)ethyl, 3- (4-methylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3-(methylsulphonyl)propyl, 3- (ethylsulphinyl)propyl, 3 -(ethylsulphonyl)propyl, 2-(5-methyl- 1 ,2,4-triazol- 1 -yl)ethyl, moφholino, 2-((N-(3-moφholinopropylsulphonyl)-N-methyl)amino)ethyl, 2-(Q^-methyl-N-4- pyridyl)amino)ethyl, 3-(4-oxidomoφholino)propyl, 2-(2-(4-methylpiperazin-l- yl)ethoxy)ethyl, 3-(2-(4-methylpiperazin-l-yl)ethoxy)propyl, 2-(2-moφholinoethoxy)ethyl, 3- (2-moφholinoethoxy)propyl, 2-(tetrahydropyran-4-yloxy)ethyl, 3 -(tetrahydropyran-4- yloxy)propyl, 2-((2-(pyrrolidin- 1 -yl)ethyl)carbamoyl) vinyl, 3 -((2-(pyrrolidin- 1 - yl)ethyl)carbamoyl)prop-2-en- 1 -yl, 1 -(2-pyπolidinylethyl)piperidin-4-ylmethyl, 1 -(3- pyrrolidinylpropyl)piperidin-4-ylmethyl, 1 -(2-piperidinylethyl)piperidin-4-ylmethyl, 1 -(3- piperidinylpropyl)piperidin-4-ylmethyl, l-(2-moφholinoethyl)piperidin-4-ylmethyl, l-(3- moφholinopropyl)piperidin-4-ylmethyl, l-(2-thiomoφholinoethyl)piperidin-4-yhnethyl, l-(3- thiomoφholinopropyl)piperidin-4-ylmethyl, l-(2-azetidinylethyl)piperidin-4-yfmethyl or l-(3- azetidinylpropyl)piperidin-4-ylmethyl, 3-moφholino-2-hydroxypropyl, (2i?)-3-moφholino-2- hydroxypropyl, (2S)-3-moφholino-2-hydroxypropyl, 3-piperidino-2-hydroxypropyl, (2R)-3- piperidino-2-hydroxypropyl, (2S)-3-piperidino-2-hydroxypropyl, 3 -pyrrohdin- l-yl-2- hydroxypropyl, (2R)-3 -pyrrohdin- 1 -yl-2-hydroxypropyl, (2S)-3 -pyrrohdin- 1 -yl-2- hydroxypropyl, 3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, (2i?)-3-(l-methylpiperazin-4-yl)- 2-hydroxypropyl, (2S)-3-(l-methylpiperazin-4-yl)-2-hydroxypropyl, 3-(N,N-diethylamino)-2- hydroxypropyl, (2i?)-3-(N,N-diethylamino)-2-hydroxyproρyl, (2S)-3-(N,N-diethylamino)-2- hydroxypropyl, 3-(isopropylamino)-2-hydroxypropyl, (2i?)-3-(isopropylamino)-2- hydroxypropyl, (2S)-3 -(isopropylamino)-2-hydroxypropyl, 3 -(N,N-diisopropylamino)-2- hydroxypropyl, (2i?)-3-(N,N-diisopropylamino)-2-hydroxypropyl or (2S)-3-(N,N- diisopropylamino)-2-hydroxypropyl]. In another aspect R 2 represents ethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, 2- hydroxyethoxy, 3-hydroxypropoxy, 2-methoxyethoxy, 3-methoxypropoxy, 2- (methylsulphinyl)ethoxy, 2-(methylsulphonyl)ethoxy, 2-(ethylsulphinyl)ethoxy, 2- (ethylsulphonyl)ethoxy, 2-(N,N-dimethylsulphamoyl)ethoxy, 2-(N^methylsulphamoyl)ethoxy, 2-sulphamoylethoxy, 2-(methylamino)ethoxy, 3-(methylamino)propoxy, 2- (ethylamino)ethoxy, 3-(ethylamino)propoxy, 2-(N,N-dimethylamino)ethoxy, 3-(N,N- dimethylamino)propoxy, 2-(N,N-diethylamino)ethoxy, 3-(N,N-diethylamino)propoxy, 2-(N- methyl-N-methylsulphonylamino)ethoxy, 3 -(N-methyl-N-methylsulphonylamino)propoxy, 2- moφholinoethoxy, 3-moφholinopropoxy, 2-piperidinoethoxy, 3-piperidinopropoxy, 2- (methylpiperidino)ethoxy, 3-(methylpiperidino)propoxy, 2-(ethylpiperidino)ethoxy, 3- (ethylpiperidino)propoxy, 2-((2-methoxyethyl)piperidino)ethoxy, 3-((2- methoxyethyl)piρeridino)propoxy, 2-((2-methylsulphonyl)ethylpiperidino)ethoxy, 3-((2- methylsulphonyl)ethylpiperidino)propoxy, piperidin-3-ylmethoxy, piperidin-4-ylmethoxy, 2- (piperidin-3-yl)ethoxy, 2-(piperidin-4-yl)ethoxy, 3-(piperidin-3-yl)propoxy, 3-(piperidin-4- yl)propoxy, 2-(ρiperidin-2-yl)ethoxy, 3-(piperidin-2-yl)propoxy, (l-methylpiperidin-3- yl)methoxy, (l-methylpiperidin-4-yl)methoxy, (l-cyanomethylpiperidin-3-yl)methoxy, (1- cyanomethylpiperidin-4-yl)methoxy, 2-(methylpiperidin-3-yl)ethoxy, 2-(methylpiperidin-4- yl)ethoxy, 2-(l-cyanomethylpiperidin-3-yl)ethoxy, 2-(l-cyanomethylpiperidin-4-yl)ethoxy, 3- (methylpiperidin-3-yl)propoxy, 3-(methylpiperidin-4-yl)propoxy, 3-(l-cyanomethylpiperidin- 3-yl)propoxy, 3-(l-cyanomethylpiperidin-4-yl)propoxy, 2-(ethylpiperidin-3-yl)ethoxy, 2- (ethylpiperidin-4-yl)ethoxy, 3-(ethylpiperidin-3-yl)propoxy, 3-(ethylpiperidin-4-yl)propoxy, ((2-methoxyethyl)piperidin-3-yl)methoxy, ((2-methoxyethyl)piperidin-4-yl)methoxy, 2-((2- methoxyethyl)piperidin-3-yl)ethoxy, 2-((2-methoxyethyl)piperidin-4-yl)ethoxy, 3-((2- methoxyethyl)piperidin-3-yl)propoxy, 3-((2-methoxyethyl)piperidin-4-yl)propoxy, (l-(2- methylsulphonylethyl)piperidin-3-yl)methoxy, (l-(2-methylsulphonylethyl)piperidin-4- yl)methoxy, 2-((2-methylsulphonylethyl)piperidin-3-yl)ethoxy, 2-((2- methylsulphonylethyl)piperidin-4-yl)ethoxy, 3 -((2-methylsulphonylethyl)piperidin-3 - yl)propoxy, 3 -((2-methylsulphonylethyl)piperidin-4-yl)propoxy, 1 -isopropylpiperidin-2- ylmethoxy, l-isopropylpiperidin-3-ylmethoxy, l-isopropylpiperidin-4-ylmethoxy, 2-(l- isopropylpiperidin-2-yl)ethoxy, 2-(l-isopropylpiperidin-3-yl)ethoxy, 2-(l-isopropylpiperidin- 4-yl)ethoxy, 3-(l-isopropylpiperidin-2-yl)propoxy, 3-(l-isopropylpiperidin-3-yl)propoxy, 3- (1 -isopropylpiperidin-4-yl)propoxy, 2-(piperidin-4-yloxy)ethoxy, 3-(piperidin-4- yloxy)propoxy, 2-(l-(cyanomethyl)piperidin-4-yloxy)ethoxy, 3-(l-(cyanomethyl)piperidin-4- yloxy)propoxy, 2-(l-(2-cyanoethyl)piperidin-4-yloxy)ethoxy, 3-(l-(2-cyanoethyl)piperidin-4- yloxy)propoxy, 2-(piperazin-l-yl)ethoxy, 3-(piperazin-l-yl)propoxy, (pyrrolidin-2- yl)methoxy, 2-(pyrrolidin-l-yl)ethoxy, 3-(pyrrolidin-l-yl)propoxy, (2-oxo-tetiahydro-2H- pyrrolidin-5-yl)methoxy, 5(i?)-(2-oxo-tetrahydro-2H-pyrrolidin-5-yl)methoxy, (5S)-(2-oxo- tetrahydro-2H-pyrrolidin-5-yl)methoxy, (1 ,3-dioxolan-2-yl)methoxy, 2-(l ,3-dioxolan-2- yfjethoxy, 2-(2-methoxyethylamino)ethoxy, 2-(N-(2-methoxyethyl)-N-methylamino)ethoxy, 2-(2-hydroxyethylamino)ethoxy, 3-(2-methoxyethylamino)propoxy, 3-(N-(2-methoxyethyl)- N-methylamino)propoxy, 3-(2-hydroxyethylamino)propoxy, 2-(l,2,3-triazol-l-yl)ethoxy, 2- (l,2,3-triazol-2-yl)ethoxy, 2-(l,2,4-triazol-l-yl)ethoxy, 2-(l,2,4-triazol-4-yl)ethoxy, 4- pyridylmethyl, 2-(4-pyridyl)ethyl, 4-pyridylmethoxy, 2-(4-pyridyl)ethoxy, 3-(4- pyridyl)propoxy, 2-(4-pyridyloxy)ethoxy, 2-(4-pyridylamino)ethoxy, 2-(4-oxo-l,4-dihydro-l- pyridyl)ethoxy, 2-(2-oxo-imidazolidin-l-yl)ethoxy, 3-(2-oxo-imidazolidin-l-yl)propoxy, 2- thiomoφholinoethoxy, 3-thiomoφholinopropoxy, 2-(l,l-dioxothiomoφholino)ethoxy, 3- (l,l-dioxothiomoφholino)ρropoxy, 2-(2-methoxyethoxy)ethoxy, 2-(4-methylpiperazin-l- yl)ethoxy, 3-(4-methylpiperazin-l-yl)propoxy, 3-(methylsulphinyl)propoxy, 3- (methylsulphonyl)propoxy, 3-(ethylsulphinyl)propoxy, 3-(ethylsulphonyl)propoxy, 2-(5- methyl-l,2,4-triazol-l-yl)ethoxy, 2-((N-(3-moφholinopropylsulphonyl)-N- methyl)amino)ethoxy, 2-((N-methyl-N-4-pyridyl)amino)ethoxy, 3-(4- oxidomoφholino)propoxy, 2-(2-(4-methylpiperazin- 1 -yl)ethoxy)ethoxy, 3-(2-(4- methylpiperazin-l-yl)ethoxy)propoxy, 2-(2-moφholinoethoxy)ethoxy, 3-(2- moφholinoethoxy)propoxy, 2-(tetrahydropyran-4-yloxy)ethoxy, 3-(tetrahydropyran-4- yloxy)propoxy, 2-((2-(pyrrolidin- 1 -yl)ethyl)carbamoyl)vinyl, 3 -((2-(pyrrolidin- 1 - yl)ethyl)carbamoyl)prop-2-en-l-yloxy, l-(2-ρyrrolidinylethyl)piperidin-4-ylmethoxy, l-(3- pyπolidinylpropyl)piperidin-4-ylmethoxy, 1 -(2-piperidinylethyl)piperidin-4-ylmethoxy, 1 -(3- piperidinylpropyl)piperidin-4-ylmethoxy, 1 -(2-moφholinoethyl)piperidin-4-ylmethoxy, 1 -(3 - moφholinopropyl)piperidin-4-ylmethoxy, l-(2-thiomoφholinoethyl)piperidin-4-ylmethoxy, 1 -(3-thiomoφholinopropyl)piperidin-4-ylmethoxy, 1 -(2-azetidinylethyl)piperidin-4- ylmethoxy or l-(3-azetidinylpropyl)piperidin-4-ylmethoxy, 3-moφholino-2-hydroxypropoxy, (2i?)-3-moφholino-2-hydroxypropoxy, (2S)-3-moφholino-2-hydroxypropoxy, 3-piperidino-2- hydroxypropoxy, (2i-)-3-piperidino-2-hydroxypropoxy, (2S)-3-piperidino-2-hydroxypropoxy, 3 -pyrrohdin- 1 -yl-2-hydroxypropoxy, (2 i?)-3 -pyrrohdin- 1 -yl-2-hydroxypropoxy, (2S)-3 - pyrrohdin- l-yl-2-hydroxypropoxy, 3-(l-methylpiperazin-4-yl)-2-hydroxypropoxy, (2R)-3-(l- methylpiperazin-4-yl)-2-hydroxypropoxy, (2S)-3-(l -methylpiperazin-4-yl)-2-hydroxypropoxy, 3-(N . N-diethylamino)-2-hydroxypropoxy, (2i?)-3-(N,N-diethylamino)-2-hydroxypropoxy, (2>S)-3-(N,N-diethylamino)-2-hydroxypropoxy, 3-(isopropylamino)-2-hydroxypropoxy, (2R)- 3-(isopropylamino)-2-hydroxypropoxy, (2S)-3-(isopropylamino)-2-hydroxypropoxy, 3-(N,N- diisopropylamino)-2-hydroxypropoxy, (2i?)-3-(N,N-diisopropylamino)-2-hydroxypropoxy or (2S)-3-(N,N-diisopropylamino)-2-hydroxypropoxy. Where one ofthe R 2 substituents is R 5 X 1 - the substituent R 5 X J - is preferably at the position of ring C which would correspond to either the 6- or 7-position of a 10-membered bicychc moiety which is attached to Z at the 4-position. In another aspect ofthe present invention there is provided the use of compounds of the formula I, as defined hereinbefore with the proviso that Z is-O-, or a salt thereof, or a prodrug thereof for example an ester or an amide, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warmblooded animals such as humans. hi another aspect ofthe present invention there is provided the use of compounds of the formula la: (la) wherein ring C, R , R 1 , R 2 , m and n are as defined hereinbefore and Za represents -O-, -CH 2 -, -NH- or -S-; or a salt thereof, or a prodrug thereof for example an ester or an amide, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans. hi another aspect ofthe present invention there is provided the use of compounds of the formula lb: (lb) wherein ring C, R , R 1 , R 2 , m and n are as defined hereinbefore and Zb represents -O-, -NH- or -S-; or a salt thereof, or a prodrug thereof for example an ester or an amide, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans. In another aspect ofthe present invention there is provided the use of compounds of the foπnula lc: (lc) wherein ring C, R b , R 1 , R 2 , m and n are as defined hereinbefore and Zc represents -O-; or a salt thereof, or a prodrug thereof for example an ester or an amide, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans. hi another aspect ofthe present invention there is provided the use of compounds of the formula lb as defined hereinbefore with the proviso that when ring C is wherein Zb is as defined hereinbefore, (but Zb is not a part of ring C, it is shown for the puφoses of clarity), at least one R does not have a value selected from hydrogen, halogeno, Cι -4 alkyl, C_. 4 alkoxy and NR c R d (wherein each of R c and R d independently represents hydrogen, d_ alkyl or phenyl which phenyl may bear 1-3 substituents selected from halogeno, trifluoromethyl, C 1-4 alkyl and C 1-4 alkoxy); or a salt thereof, or a prodrug thereof for example an ester or an amide, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans. According to another aspect ofthe present invention there is provided a compound ofthe formula I as defined hereinbefore and salts thereof, and prodrugs thereof for example esters and amides. According to another aspect ofthe present invention there is provided a compound ofthe foπnula I as defined hereinbefore and salts thereof, and prodrugs thereof for example esters and amides with the proviso that Z is -O-. According to another aspect ofthe present invention there is provided a compound ofthe formula I 1 as defined hereinbefore and salts thereof, and prodrugs thereof for example esters, amides and sulphides, preferably esters and amides. According to another aspect ofthe present invention there is provided a compound ofthe formula la as defined hereinbefore and salts thereof, and prodrugs thereof for example esters and amides. According to another aspect ofthe present invention there is provided a compound ofthe formula lb as defined hereinbefore and salts thereof, and prodrugs thereof for example esters and amides. According to another aspect ofthe present invention there is provided a compound ofthe formula lc as defined hereinbefore and salts thereof, and prodrugs thereof for example esters and amides. According to another aspect ofthe present invention there is provided a compound ofthe formula lb as defined hereinbefore with the proviso that if Z is -NH- then: at least one R 2 is not selected from hydrogen, chloro, bromo, methyl, phenyl(hydroxymethyl), dimethylamino, methylsulphanyl, methylsulphinyl, methylsulphonyl and hydroxycyclohexylamino ; X 1 is not selected from -CH -, a direct bond and -C(O)NR 7 -; and where R 2 is a group R^X 1 and X 1 is -NR 6 C(O)- or -NR 9 SO 2 -, R 5 does not contain an alkenyl or alkynyl moiety; and salts thereof, and prodrugs thereof for example esters and amides. According to another aspect ofthe present invention there is provided a compound o the formula lb as defined hereinbefore with the proviso that if Z is -NH- then: at least one R is not selected from hydrogen, chloro, bromo, methyl, phenyl(hydroxymethyl), dimethylamino, methylsulphanyl, methylsulphinyl, methylsulphonyl and hydroxycyclohexylamino; X 1 is not selected from -CH 2 -, a direct bond and -C(O)NR 7 -; and where R 2 is a group R 5 -X ! and X 1 is -NR 6 C(O)- or -NR 9 SO 2 -, R 5 does not contain an alkenyl or alkynyl moiety; and with the further proviso that when ring C is wherein Zb is as defined hereinbefore, (but Zb is not a part of ring C, it is shown for the puφoses of clarity), at least one R 2 does not have a value selected from hydrogen, halogeno, C 1- alkyl, Cι- 4 alkoxy andNR c R d (wherein each of R c and R d independently represents hydrogen, Cι -4 alkyl or phenyl which phenyl may bear 1-3 substituents selected from halogeno, trifluoromethyl, Cι_ 4 alkyl and Cι- 4 alkoxy); and salts thereof, and prodrugs thereof for example esters and amides. According to one aspect ofthe present invention preferred examples are: 1 -(4-fluoroindol-5 -yloxy)-4-(4-pyridylmethyl)phthalazine, l-(indol-6-yloxy)-4-(4-pyridylmethyl)phthalazine, 1 -(2-methylindol-6-yloxy)-4-(4-pyridylmethyl)phthalazine, 4-(4-fluoro-2-methylindol-5-yloxy)thieno[3,2-d]pyrimidine and l-(4-fluoro-2-methylindol-5-yloxy)-4-(4-pyridylmethyl)phthalazine, and salts thereof. hi another aspect preferred compounds ofthe present invention are 4-(4-fluoro-2-methylindol-5-yloxy)thieno[3,2-d]pyrimidine and l-(4-fluoro-2-methylindol-5-yloxy)-4-(4-pyridylmethyl)phthalazine and salts thereof. For the avoidance of doubt it is to be understood that where in this specification a group is qualified by 'hereinbefore defined' or 'defined hereinbefore' the said group encompasses the first occurring and broadest definition as well as each and all ofthe preferred definitions for that group. In this specification unless stated otherwise the term "alkyl" includes both straight and branched chain alkyl groups but references to individual alkyl groups such as "propyl" are specific for the straight chain version only. An analogous convention applies to other generic terms. Unless otherwise stated the term "alkyl" advantageously refers to chains with 1-6 carbon atoms, preferably 1-4 carbon atoms. The term "alkoxy" as used herein, unless stated otherwise includes "alkyl"-O- groups in which "alkyl" is as hereinbefore defined. The term "aryl" as used herein unless stated otherwise includes reference to a C 6 - 10 aryl group which may, if desired, carry one or more substituents selected from halogeno, alkyl, alkoxy, nitro, trifluoromethyl and cyano, (wherein alkyl and alkoxy are as hereinbefore defined). The term "aryloxy" as used herein unless otherwise stated includes "aryl"-O-groups in which "aryl" is as hereinbefore defined. The term "sulphonyloxy" as used herein refers to alkylsulphonyloxy and arylsulphonyloxy groups in which "alkyl" and "aryl" are as hereinbefore defined. The term "alkanoyl" as used herein unless otherwise stated includes formyl and alkylC-=O groups in which "alkyl" is as defined hereinbefore, for example dalkanoyl is ethanoyl and refers to CH 3 C=O, Ci alkanoyl is formyl and refers to CHO. In this specification unless stated otherwise the term "alkenyl" includes both straight and branched chain alkenyl groups but references to individual alkenyl groups such as 2-butenyl are specific for the straight chain version only. Unless otherwise stated the term "alkenyl" advantageously refers to chains with 2-5 carbon atoms, preferably 3-4 carbon atoms. In this specification unless stated otherwise the term "alkynyl" includes both straight and branched chain alkynyl groups but references to individual alkynyl groups such as 2-butynyl are specific for the straight chain version only. Unless otherwise stated the term "alkynyl" advantageously refers to chains with 2-5 carbon atoms, preferably 3-4 carbon atoms. Unless stated otherwise the term "haloalkyl" refers to an alkyl group as defined hereinbefore which bears one or more halogeno groups, such as for example trifluoromethyl. For the avoidance of any doubt, where R 2 has a value of substituted or unsubstituted o S 1 1 Cι- 5 alkyl, R has been selected from Cι_ 3 alkyl or from a group R X wherein X is a direct bond or -CH 2 - and R 5 is Ci-salkyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, chloro, bromo and amino. Within the present invention it is to be understood that a compound ofthe formula I or a salt thereof may exhibit the phenomenon of tautomerism and that the formulae drawings within this specification can represent only one ofthe possible tautomeric forms. It is to be understood that the invention encompasses any tautomeric form which inhibits VEGF receptor tyrosine kinase activity and is not to be limited merely to any one tautomeric form utilised within the formulae drawings. The foπnulae drawings within this specification can represent only one ofthe possible tautomeric forms and it is to be understood that the specification encompasses all possible tautomeric forms ofthe compounds drawn not just those forms which it has been possible to show graphically herein. It will be appreciated that compounds ofthe formula I or a salt thereof may possess an asymmetric carbon atom. Such an asymmetric carbon atom is also involved in the tautomerism described above, and it is to be understood that the present invention encompasses any chiral form (including both pure enantiomers, scalemic and racemic mixtures) as well as any tautomeric form which inhibits VEGF receptor tyrosine kinase activity, and is not to be limited merely to any one tautomeric form or chiral form utilised within the formulae drawings. It is to be understood that the invention encompasses all optical and diastereomers which inhibit VEGF receptor tyrosine kinase activity. It is further to be understood that in the names of chiral compounds (R,S) denotes any scalemic or racemic mixture while (R) and (S) denote the enantiomers. i the absence of (R,S), (R) or (S) in the name it is to be understood that the name refers to any scalemic or racemic mixture, wherein a scalemic mixture contains R and S enantiomers in any relative proportions and a racemic mixture contains R and S enantiomers in the ration 50:50. It is also to be understood that certain compounds ofthe formula I and salts thereof can exist in solvated as well as unsolvated forms such as, for example, hydrated forms. It is to be understood that the invention encompasses all such solvated forms which inhibit VEGF receptor tyrosine kinase activity. For the avoidance of any doubt, it is to be understood that when X 1 is, for example, a group of formula -NR 6 C(O)-, it is the nitrogen atom bearing the R 6 group which is attached to ring C and the carbonyl (C(O)) group is attached to R 5 , whereas when X 1 is, for example, a group of formula -C(O)NR 7 -, it is the carbonyl group which is attached to ring C and the nitrogen atom bearing the R 7 group is attached to R 5 . A similar convention applies to the other two atom X 1 linking groups such as -NR 9 SO 2 - and -SO 2 NR 8 -. When X 1 is -NR 10 - it is the nitrogen atom bearing the R 10 group which is linked to ring C and to R 5 . An analogous convention applies to other groups. It is further to be understood that when X 1 represents - NR 10 - and R 10 is C 1-3 alkoxyC 2 - 3 alkyl it is the dialkyl moiety which is linked to the nitrogen atom of X 1 and an analogous convention applies to other groups. For the avoidance of any doubt, it is to be understood that in a compound ofthe formula I when R 5 is, for example, a group of formula C 1-3 alkylX 9 d- 3 alkylR 29 , it is the terminal C 1 - 3 alkyl moiety which is linked to X 1 , similarly when R 5 is, for example, a group of formula d-salkenylR 28 it is the d-salkenyl moiety which is linked to X 1 and an analogous convention applies to other groups. When R is a group 1-R prop-l-en-3-yl it is the first carbon to which the group R 29 is attached and it is the third carbon which is linked to X 1 and an analogous convention applies to other groups. For the avoidance of any doubt, it is to be understood that in a compound ofthe formula I when R 5 is, for example, R 28 and R 28 is a pyrrolidinyl ring which bears a group -(-O- ) f (Cι -4 alkyl) g ringD, it is the -O- or Cι -4 alkyl which is linked to the pyrrolidinyl ring, unless f and g are both 0 when it is ring D which is linked to the pyrrolidinyl ring and an analogous convention applies to other groups. For the avoidance of any doubt, it is to be understood that when R 29 carries a Ci- 4 aminoalkyl substituent it is the Cι- 4 alkyl moiety which is attached to R 29 whereas when R 29 carries a Cι -4 alkylamino substituent it is the amino moiety which is attached to R 29 and an analogous convention applies to other groups. For the avoidance of any doubt, it is to be understood that when R 28 carries a Ci- 4 alkoxyC 1-4 alkyl substituent it is the Cι -4 alkyl moiety which is attached to R 28 and an analogous convention applies to other groups. For the avoidance of any doubt, it is to be understood that when R 1 is -Cι- 5 alkyl(ring B) it is the alkyl chain which is linked to the indole group and ring B is attached to the alkyl chain and an analogous convention applies to other groups. For the avoidance of any doubt, it is to be understood that when R is C 2 - salkenylaminoC M alkyl, it is the Cι_ 4 alkyl group which is linked to the nitrogen atom ofthe 5- membered ring and an analogous convention applies to other groups. The present invention relates to the compounds of formula I as hereinbefore defined as well as to the salts thereof. Salts for use in pharmaceutical compositions will be pharmaceutically acceptable salts, but other salts may be useful in the production ofthe compounds of formula I and their pharmaceutically acceptable salts. Pharmaceutically acceptable salts ofthe invention may, for example, include acid addition salts ofthe compounds of formula I as hereinbefore defined which are sufficiently basic to form such salts. Such acid addition salts include for example salts with inorganic or organic acids affording pharmaceutically acceptable anions such as with hydrogen halides (especially hydrochloric or hydrobromic acid of which hydrochloric acid is particularly preferred) or with sulphuric or phosphoric acid, or with trifluoroacetic, citric or maleic acid. In addition where the compounds of formula I are sufficiently acidic, pharmaceutically acceptable salts maybe formed with an inorganic or organic base which affords a pharmaceutically acceptable cation. Such salts with inorganic or organic bases include for example an alkali metal salt, such as a sodium or potassium salt, an alkaline earth metal salt such as a calcium or magnesium salt, an ammonium salt or for example a salt with methylamine, dimethylamine, trimethylamine, piperidine, moφhotine or tris-(2-hydroxyethyl)amine. A compound ofthe formula I, or salt thereof, and other compounds ofthe invention (as hereinafter defined) may be prepared by any process known to be applicable to the preparation of chemically-related compounds. Such processes include, for example, those illustrated in International Patent Application Publicaiton No. WO 00/47212 (Application No. PCT/GB00/00373). Such processes also include, for example, solid phase synthesis. Such processes, are provided as a further feature ofthe invention and are as described hereinafter. Necessary starting materials maybe obtained by standard procedures of organic chemistry. The preparation of such starting materials is described within the accompanying non-limiting Examples. Alternatively necessary starting materials are obtainable by analogous procedures to those illustrated which are within the ordinary skill of an organic chemist. Thus, the following processes (a) to (f) and (i) to (vi) constitute further features of the present invention. .Svnthesis of Compounds of Formula I (a) Compounds of the formula I and salts thereof may be prepared by the reaction of a compound ofthe formula HI: (01) (wherein ring C, R 2 and m are as defined hereinbefore and L 1 is a displaceable moiety), with a compound ofthe formula IV: (TV) (wherein R b , R 1 , G ls G 2 , G 3 , G 4 , G 5 , Z and n are as defined hereinbefore) to obtain compounds ofthe formula I and salts thereof. A convenient displaceable moiety L 1 is, for example, a halogeno, alkoxy (preferably Cι- alkoxy), aryloxy, alkylsulphanyl, arylsulphanyl, alkoxyalkylsulphanyl or sulphonyloxy group, for example a chloro, bromo, methoxy, phenoxy, methylsulphanyl, 2-methoxyethylsulphanyl, methanesulphonyloxy or toluene-4-sulphonyloxy group. The reaction is advantageously effected in the presence of a base. When Z is -O- such a base is, for example, an organic amine base such as, for example, pyridine, 2,6-lutidine, collidine, 4-dimethylaminopyridine, triethylamine, moφholine, N-methylmoφholine or diazabicyclo[5.4.0]undec-7-ene, tetramethylguanidine or for example, an alkali metal or alkaline earth metal carbonate or hydroxide, for example sodium carbonate, potassium carbonate, cesium carbonate, calcium carbonate, sodium hydroxide or potassium hydroxide. Alternatively such a base is, for example, an alkali metal hydride, for example sodium hydride, or an alkali metal or alkaline earth metal amide, for example sodium amide, sodium bis(trimethylsilyl)amide, potassium amide or potassium bis(trimethylsilyl)amide. The reaction is preferably effected in the presence of an inert solvent or diluent, for example an ether such as tetrahydrofuran or 1,4-dioxan, an aromatic hydrocarbon solvent such as toluene, or a dipolar aprotic solvent such as N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidin-2-one or dimethyl sulphoxide. The reaction is conveniently effected at a temperature in the range, for example, 10 to 150°C, preferably in the range 20 to 110°C. When Z is -NH- the reaction is advantageously effected in the presence of either an acid or a base. Such an acid is for example, an anhydrous inorganic acid such as hydrochloric acid, in the presence of a protic solvent or diluent, for example an alcohol or ester such as methanol, ethanol, 2-propanol, 2-pentanol. When it is desired to obtain the acid salt, the free base may be treated with an acid such as a hydrogen halide, for example hydrogen chloride, sulphuric acid, a sulphonic acid, for example methane sulphonic acid, or a carboxylic acid, for example acetic or citric acid, using a conventional procedure. (b) Production of those compounds of formula I and salts thereof wherein at least one R 2 is R 5 X ! wherein R 5 is as defined hereinbefore and X 1 is -O-, -S-, -OC(O)- or -NR 10 - (wherein R 10 independently represents hydrogen, Cι- 3 a_kyl or Cι- 3 aιkoxyd- 3 alkyl) can be achieved by the reaction, conveniently in the presence of a base (as defined hereinbefore in process (a)) of a compound ofthe formula V: (V) (wherein ring C, R , Z, Gi, G2, G3, G 4 , G 5 , R 1 , R 2 and n are as hereinbefore defined and X 1 is as hereinbefore defined in this section and s is 0 or 1) with a compound of formula VI: R 5 -L J (VD (wherein R 5 and L 1 are as hereinbefore defined), L 1 is a displaceable moiety for example a halogeno or sulphonyloxy group such as a bromo, methanesulphonyloxy or toluene-4- sulphonyloxy group, or L 1 may be generated in situ from an alcohol under standard Mitsunobu conditions ("Organic Reactions", John Wiley & Sons hie, 1992, vol 42, chapter 2, David L Hughes). The reaction is preferably effected in the presence of a base (as defined hereinbefore in process (a)) and advantageously in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), advantageously at a temperature in the range, for example 10 to 150°C, conveniently at about 50°C. (c) Compounds ofthe foπnula I and salts thereof wherein at least one R 2 is R 5 X J wherein R 5 is as defined hereinbefore and X 1 is -O-, -S-, -OC(O)- or -NR 10 - (wherein R 10 represents hydrogen, d- 3 alkyl or Cι- 3 alkoxyC 2 - 3 alkyl) maybe prepared by the reaction of a compound ofthe formula VII: (vπ) with a compound ofthe formula VHI: R^-H (vm) (wherein ring C, L 1 , R b , R 1 , R 2 , R 5 , Z, Gi, G 2 , G 3 , G 4 , G 5 , n and s are all as hereinbefore defined and X 1 is as hereinbefore defined in this section). The reaction may conveniently be effected in the presence of a base (as defined hereinbefore in process (a)) and advantageously in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), advantageously at a temperature in the range, for example 10 to 150°C, conveniently at about 100°C. (d) Compounds ofthe formula I and salts thereof wherein at least one R 2 is R 5 X l wherein X 1 is as defined hereinbefore and R 5 is Ci-salkylR 62 , wherein R 62 is selected from one ofthe following nine groups: 1) X 10 d- 3 alkyl (wherein X 10 represents -O-, -S-, -SO 2 -, -NR 63 C(O)- or-NR 64 SO 2 - (wherein R 63 and R 4 which may be the same or different are each hydrogen, C 1 . 3 alkyl or Cι -3 alkoxyC 2 - 3 alkyl); 2) NR R (wherein R and R which may be the same or different are each hydrogen, C_- 3alkyl or C_. 3 alkoxyC 2 - alkyl); 3) X n Cι-salkylX 5 R 22 (wherein X 11 represents -O-, -S-, -SO 2 -, -NR 67 C(O)-, -NR 68 SO 2 - or- NR 69 - (wherein R 67 , R 68 , and R 69 which may be the same or different are each hydrogen, C_- 3 alkyl or Cι_ 3 alkoxyC 2 - 3 alkyl) and X 5 and R 22 are as defined hereinbefore); 4) R 28 (wherein R 28 is as defined hereinbefore); 5) X 12 R 29 (wherein X 12 represents -O-, -S-, -SO 2 -, -NR 70 C(O)-, -NR 71 SO 2 -, or-NR 72 - (wherein R , R , and R which may be the same or different are each hydrogen, Cι -3 alkyl or Cι- 3 alkoxyC 2-3 alkyl) andR 29 is as defined hereinbefore); and 6) X 13 C 1-3 alkylR 29 (wherein X 13 represents -O-, -S-, -SO 2 -, -NR 73 C(O)-, -NR 74 SO 2 - or -NR 75 - (wherein R 73 , R 74 and R 75 each independently represents hydrogen, d- 3 alkyl or Cι-3alkoxyC - 3 alkyl) and R 29 is as defined hereinbefore); 7) R 29 (wherein R 29 is as defined hereinbefore); 8) X 13 C 1- alkylR 28 (wherein X 13 and R 28 are as defined hereinbefore); and 9) R 54 (Cι -4 alkyl) q (X 9 ) r R 55 (wherein q, r, X 9 , R 54 and R 55 are as defined hereinbefore); may be prepared by reacting a compound ofthe formula IX: iλc^alkyl-X 1 (wherein ring C, L 1 , X 1 , R , R 1 , R 2 , Gi, G 2 , G 3 , G , G 5 , Z, n and s are as hereinbefore defined) with a compound ofthe formula X: R 62 -H (X) (wherein R is as defined hereinbefore) to give a compound ofthe formula I or salt thereof. The reaction may conveniently be effected in the presence of a base (as defined hereinbefore in process (a)) and advantageously in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), and at a temperature in the range, for example 0 to 150°C, conveniently at about 50°C. Processes (a) and (b) are preferred over processes (c) and (d). Process (a) is prefeπed over processes (b), (c) and (d). (e) The production of those compounds ofthe formula I and salts thereof wherein one or more ofthe substituents (R 2 ) m is represented by -NR 76 R 77 , where one (and the other is hydrogen) or both of R 76 and R 77 are Cι- alkyl, may be effected by the reaction of compounds of foπnula I wherein the substituent (R 2 ) m is an amino group and an alkylating agent, preferably in the presence of a base as defined hereinbefore. Such alkylating agents are Cι- 3 alkyl moieties bearing a displaceable moiety as defined hereinbefore such as Cι- alkyl halides for example d- 3 alkyl chloride, bromide or iodide. The reaction is preferably effected in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)) and at a temperature in the range, for example, 10 to 100°C, conveniently at about ambient temperature. The production of compounds of formula I and salts thereof wherein one or more ofthe substituents R 2 is an amino group may be effected by the reduction of a corresponding compound of formula I wherein the substituent(s) at the coπesponding position(s) of ring C is/are a nitro group(s). The reduction ofthe nitro group may conveniently be effected by any ofthe procedures known for such a transformation. The reduction may be carried out, for example, by the hydrogenation of a solution of the nitro compound in the presence of an inert solvent or diluent as defined hereinbefore in the presence of a metal effective to catalyse hydrogenation reactions such as palladium or platinum. A further reducing agent is, for example, an activated metal such as activated iron (produced for example by washing iron powder with a dilute solution of an acid such as hydrochloric acid). Thus, for example, the reduction may be effected by heating the nitro compound and the activated metal in the presence of a solvent or diluent such as a mixture of water and alcohol, for example methanol or ethanol, to a temperature in the range, for example 50 to 150°C, conveniently at about 70°C. Where the reduction is effected in the presence of activated iron, this is advantageously produced in situ, conveniently by the use of iron, generally iron powder, in the presence of acetic acid/water and preferably at about 100°C. The production of a compound of formula I and salts thereof wherein the substituent(s) at the coπesponding position(s) of ring C is/are a nitro group(s) may be effected by the processes described hereinbefore and hereinafter in processes (a-d) and (i-v) using a compound selected from the compounds ofthe formulae (I-XVIt) in which the substituent(s) at the coπesponding position(s) of ring C is/are a nitro group(s). (f) Compounds ofthe formula I and salts thereof wherein X 1 is -SO- or -SO 2 - may be prepared by oxidation from the coπesponding compound in which X 1 is -S- or -SO- (when X 1 is -SO 2 - is required in the final product). Conventional oxidation conditions and reagents for such reactions are well known to the skilled chemist. Synthesis of Intermediates (i) The compounds of formula IE and salts thereof in which L 1 is halogeno may for example be prepared by halogenating a compound ofthe formula XI: (XI) wherein ring C, R 2 and m are as hereinbefore defined. Convenient halogenating agents include inorganic acid halides, for example thionyl chloride, plιosphorus(III)chloride, phosphorus(V)oxychloride and phosphorus(V)chloride. The halogenation reaction may be effected in the presence of an inert solvent or diluent such as for example a halogenated solvent such as methylene chloride, trichloromethane or carbon tetrachloride, or an aromatic hydrocarbon solvent such as benzene or toluene, or the reaction may be effected without the presence of a solvent. The reaction is conveniently effected at a temperature in the range, for example 10 to 150°C, preferably in the range 40 to 100°C. The compounds of formula XI and salts thereof may, for example, be prepared by reacting a compound of the formula XII: (XD) 9 1 (wherein ring C, R , s and L are as hereinbefore defined) with a compound ofthe foπnula Vm as hereinbefore defined. The reaction may conveniently be effected in the presence of a base (as defined hereinbefore in process (a)) and advantageously in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), advantageously at a temperature in the range, for example 10 to 150°C, conveniently at about 110°C. The compounds of formula XI and XII and salts thereof may be prepared by any ofthe methods known in the art of heterocyclic organic chemistry. The compounds of formula 111 and salts thereof wherein at least one R 2 is R 5 X 1 and wherein X 1 is -O-, -S-, -SO 2 -, -OC(O)-, -C(O)NR 7 -, -SO 2 NR 8 - or -NR 10 - (wherein R 7 , R 8 and R 10 each independently represents hydrogen, Ci^alkyl or Cι-3alkoxyC 2 - 3 alkyl), may also be prepared for example by reacting a compound ofthe formula XHI: pan) 9 1 (wherein ring C, R and s are as hereinbefore defined, X is as hereinbefore defined in this section and L 2 represents a displaceable protecting moiety) with a compound ofthe formula VI as hereinbefore defined, whereby to obtain a compound of formula m in which L 1 is represented by L 2 . A compound of formula Xm is conveniently used in which L 2 represents a chloro group or a phenoxy group which may if desired carry up to 5 substituents, preferably up to 2 substituents, selected from halogeno, nitro and cyano. The reaction maybe conveniently effected under conditions as described for process (b) hereinbefore. The compounds of formula m and salts thereof may for example be prepared by deprotecting a compound ofthe formula XIV: L 2 (XIV) (wherein ring C, R 2 , s and L 2 are as hereinbefore defined, P 1 is a protecting group and X 1 is as hereinbefore defined in the section describing compounds ofthe formula XUT). The choice of protecting group P 1 is within the standard knowledge of an organic chemist, for example those included in standard texts such as "Protective Groups in Organic Synthesis" T.W. Greene and RG.M.Wuts, 2nd Ed. Wiley 1991, including N-sulphonyl derivatives (for example, p- toluenesulphonyl), carbamates (for example, t-butyl carbonyl), N-alkyl derivatives (for example, 2-chloroethyl, benzyl) and amino acetal derivatives (for example benzyloxymethyl). The removal of such a protecting group may be effected by any ofthe procedures known for such a transformation, including those reaction conditions indicated in standard texts such as that indicated hereinbefore, or by a related procedure. Deprotection may be effected by techniques well known in the literature, for example where P 1 represents a benzyl group deprotection may be effected by hydrogenolysis or by treatment with trifluoroacetic acid. One compound of formula HI may if desire ^ converted into another compound of formula IH in which the moiety L 1 is different. Thus for example a compound of formula DI in which L 1 is other than halogeno, for example optionally substituted phenoxy, may be converted to a compound of foπnula m in which L 1 is halogeno by hydrolysis of a compound of foπnula in (in which L 1 is other than halogeno) to yield a compound of formula XI as hereinbefore defined, followed by introduction of halide to the compound of fonnula XI, thus obtained as hereinbefore defined, to yield a compound of fonnula UJ in which L 1 represents halogen, (ii) Compounds of formula TV may be prepared by any ofthe methods known in the art, such as for example those described in "Indoles Part I", "Indoles Part II", 1972 John Wiley & Sons Ltd and "Indoles Part m" 1979, John Wiley & Sons Ltd, edited by W. J. Houlihan. Compounds of formula IV maybe prepared by any ofthe methods described in the Examples hereinafter. Compounds of formula TV may be prepared by any ofthe processes described in International Patent Application Publication No. WO 00/47212, the entire content of which is included herein by reference, with particular reference to the processes described in WO 00/47212 in Examples 48, 182 237, 242, 250 and 291 therein. For example the azaindole 2-methyl-lH-pyrrolo[2,3-6]pyridin-5-ol, maybe prepared according to the method described in Reference Example 1 hereinafter. (iii) Compounds of formula V as hereinbefore defined and salts thereof may be made by deprotecting the compound of formula XV: (XV) (wherein ring C, R , Z, Gi, G 2 , G 3 , G 4 , G 5 , R 1 , R 2 , P 1 , n and s are as hereinbefore defined and X 1 is as hereinbefore defined in the section describing compounds ofthe foπnula V) by a process for example as described in (i) above. Compounds ofthe formula XV and salts thereof may be made by reacting compounds ofthe formulae XIV and IV as hereinbefore defined, under the conditions described in (a) hereinbefore, to give a compound ofthe formula XV or salt thereof, (iv) Compounds ofthe formula VII and salts thereof may be made by reacting a compound of the formula XVI: (XVI) (wherein ring C, R 2 , s and each L 1 are as hereinbefore defined and the L 1 in the 4-position and the other L 1 in a further position on ring C may be the same or different) with a compound of the formula IV as hereinbefore defined, the reaction for example being effected by a process as described in (a) above. (v) Compounds of formula IX as defined hereinbefore and salts thereof may for example be made by the reaction of compounds of formula V as defined hereinbefore with compounds ofthe formula XVU: L^d-salkyl-L 1 (XVΉ) (wherein L 1 is as hereinbefore defined) to give compounds of formula IX or salts thereof. The reaction may be effected for example by a process as described in (b) above, (vi) Intermediate compounds wherein X 1 is -SO- or -SO 2 - may be prepared by oxidation from the corresponding compound in which X 1 is -S- or -SO- (when X 1 is -SO 2 - is required in the final product). Conventional oxidation conditions and reagents for such reactions are well known to the skilled chemist. When a pharmaceutically acceptable salt of a compound ofthe formula I is required, it may be obtained, for example, by reaction of said compound with, for example, an acid using a conventional procedure, the acid having a pharmaceutically acceptable anion. Many ofthe intermediates defined herein, for example, those ofthe formulae IV, V, VII, LX and XV are novel and these are provided as a further feature ofthe invention. The preparation of these compounds is as described herein and/or is by methods well known to persons skilled in the art of organic chemistry. The identification of compounds which potently inhibit the tyrosine kinase activity associated with VEGF receptors such as Fit and/or KDR and which inhibit angiogenesis and/or increased vascular permeability is desirable and is the subject ofthe present invention. These properties may be assessed, for example, using one or more ofthe procedures set out below: ( ) In Vitro Receptor Tyrosine Kinase Inhibition Test This assay determines the ability of a test compound to inhibit tyrosine kinase activity. DNA encoding VEGF, FGF or EGF receptor cytoplasmic domains may be obtained by total gene synthesis (Edwards M, International Biotechnology Lab 5(3), 19-25, 1987) or by cloning. These may then be expressed in a suitable expression system to obtain polypeptide with tyrosine kinase activity. For example VEGF, FGF and EGF receptor cytoplasmic domains, which were obtained by expression of recombinant protein in insect cells, were found to display intrinsic tyrosine kinase activity, hi the case ofthe VEGF receptor Fit (Genbank accession number X51602), a 1.7kb DNA fragment encoding most ofthe cytoplasmic domain, commencing with methionine 783 and including the termination codon, described by Shibuya et al (Oncogene, 1990, 5: 519-524), was isolated from cDNA and cloned into a baculovirus fransplacement vector (for example pAcYMl (see The Baculovirus Expression System: A Laboratory Guide, L.A. King and R. D. Possee, Chapman and Hall, 1992) or pAc360 or pBlueBacHis (available from ivitrogen Coφoration)). This recombinant construct was co-transfected into insect cells (for example Spodoptera frugiperda 21(Sf21)) with viral DNA (eg Pharmingen BaculoGold) to prepare recombinant baculovirus. (Details of the methods for the assembly of recombinant DNA molecules and the preparation and use of recombinant baculovirus can be found in standard texts for example Sambrook et al, 1989, Molecular cloning - A Laboratory Manual, 2nd edition, Cold Spring Harbour Laboratory Press and O'Reilly et al, 1992, Baculovirus Expression Vectors - A Laboratory Manual, W. H. Freeman and Co, New York). For other tyrosine kinases for use in assays, cytoplasmic fragments starting from methionine 806 (KDR, Genbank accession number L04947), methionine 668 (EGF receptor, Genbank accession number X00588) and methionine 399 (FGF RI receptor, Genbank accession number X51803) may be cloned and expressed in a similar manner. For expression of cFlt tyrosine kinase activity, Sf21 cells were infected with plaque-pure cFlt recombinant virus at a multiplicity of infection of 3 and harvested 48 hours later. Harvested cells were washed with ice cold phosphate buffered saline solution (PBS) (lOmM sodium phosphate pH7.4, 138mM sodium chloride, 2.7mM potassium chloride) then resuspended in ice cold HNTG/PMSF (20mM Hepes pH7.5, 150mM sodium chloride, 10% v/v glycerol, 1% v/v Triton XI 00, 1.5mM magnesium chloride, lmM ethylene glycol- bis(βaminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA), lmM PMSF (phenylmethylsulphonyl fluoride); the PMSF is added just before use from a freshly-prepared lOOmM solution in methanol) using 1ml HNTG/PMSF per 10 million cells. The suspension was centrifuged for 10 minutes at 13,000 rpm at 4°C, the supernatant (enzyme stock) was removed and stored in aliquots at -70°C. Each new batch of stock enzyme was titrated in the assay by dilution with enzyme diluent (lOOmM Hepes pH 7.4, 0.2mM sodium orthovanadate, 0.1% v/v Triton X100, 0.2mM dithiothreitol). For a typical batch, stock enzyme is diluted 1 in 2000 with enzyme diluent and 50μl of dilute enzyme is used for each assay well. A stock of substrate solution was prepared from a random copolymer containing tyrosine, for example Poly (Glu, Ala, Tyr) 6:3:1 (Sigma P3899), stored as 1 mg/ml stock in PBS at -20°C and diluted 1 in 500 with PBS for plate coating. On the day before the assay lOOμl of diluted substrate solution was dispensed into all wells of assay plates (Nunc maxisoφ 96- well immunoplates) which were sealed and left overnight at 4°C. On the day ofthe assay the substrate solution was discarded and the assay plate wells were washed once with PBST (PBS containing 0.05% v/v Tween 20) and once with 50mM Hepes pH7.4. Test compounds were diluted with 10% di ethylsulphoxide (DMSO) and 25 μl of 5 diluted compound was transfeπed to wells in the washed assay plates. "Total" control wells contained 10% DMSO instead of compound. Twenty five micro litres of 40mM manganese(H)chloride containing 8μM adenosine-5 '-triphosphate (ATP) was added to all test wells except "blank" control wells which contained manganese(II)chloride without ATP. To start the reactions 50μl of freshly diluted enzyme was added to each well and the plates were 10 incubated at room temperature for 20 minutes. The liquid was then discarded and the wells were washed twice with PBST. One hundred microlitres of mouse IgG anti-phosphotyrosiiie antibody (Upstate Biotechnology hie. product 05-321), diluted 1 in 6000 with PBST containing 0.5% w/v bovine serum albumin (BSA), was added to each well and the plates were incubated for 1 hour at room temperature before discarding the liquid and washing the 15 wells twice with PBST. One hundred microlitres of horse radish peroxidase (HRP)-linked sheep anti-mouse Ig antibody (Amersham product NXA 931), diluted 1 in 500 with PBST containing 0.5% w/v BSA, was added and the plates were incubated for 1 hour at room temperature before discarding the liquid and washing the wells twice with PBST. One hundred microlitres of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) 20 solution, freshly prepared using one 50mg ABTS tablet (Boehringer 1204 521) in 50ml freshly prepared 50mM phosphate-citrate buffer pH5.0 + 0.03% sodium perborate (made with 1 phosphate citrate buffer with sodium perborate (PCSB) capsule (Sigma P4922) per 100ml distilled water), was added to each well. Plates were then incubated for 20-60 minutes at room temperature until the optical density value ofthe "total" control wells, measured at 25 405nm using a plate reading spectrophotometer, was approximately 1.0. "Blank" (no ATP) and "total" (no compound) control values were used to determine the dilution range of test compound which gave 50% inhibtion of enzyme activity. (b) hi Vitro HUVEC Proliferation Assay 30 This assay determines the ability of a test compound to inhibit the growth factor- stimulated proliferation of human umbilical vein endothelial cells (HUVEC). HUVEC cells were isolated in MCDB 131 (Gibco BRL) + 7.5% v/v foetal calf serum (FCS) and were plated out (at passage 2 to 8), in MCDB 131 + 2% v/v FCS + 3 μg/ml heparin + 1 μg/ml hydrocortisone, at a concentration of 1000 cells/well in 96 well plates. After a minimum of 4 hours they were dosed with the appropriate growth factor (i.e. VEGF 3ng/ml, EGF 3ng/ml or b-FGF 0.3ng/ml) and compound. The cultures were then incubated for 4 days at 37°C with 7.5% CO 2 . On day 4 the cultures were pulsed with lμCi/well of tritiated-thymidine (Amersham product TRA 61) and incubated for 4 hours. The cells were harvested using a 96-well plate harvester (Tomtek) and then assayed for incoφoration of tritium with a Beta plate counter, hicoφoration of radioactivity into cells, expressed as cpm, was used to measure inliibition of growth factor-stimulated cell proliferation by compounds. (c hi Vivo Solid Tumour Disease Model This test measures the capacity of compounds to inhibit solid tumour growth. CaLu-6 tumour xenografts were established in the flank of female athymic Swiss nu/nu mice, by subcutaneous injection of lxlO 6 CaLu-6 cells/mouse in lOOμl of a 50% (v/v) solution of Matrigel in serum free culture medium. Ten days after cellular implant, mice were allocated to groups of 8-10, so as to achieve comparable group mean volumes. Tumours were measured using vernier calipers and volumes were calculated as: (I x wj x V(/ x w) x (π/6) , where is the longest diameter and w the diameter peφendicular to the longest. Test compounds were administered orally once daily for a minimum of 21 days, and control animals received compound diluent. Tumours were measured twice weekly. The level of growth inhibition was calculated by comparison ofthe mean tumour volume ofthe control group versus the treatment group using a Student T test and/or a Mann- Whitney Rank Sum Test. The inhibitory effect of compound treatment was considered significant when p<0.05. According to a further aspect ofthe invention there is provided a pharmaceutical composition which comprises a compound ofthe formula I as defined hereinbefore or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable excipient or carrier. The composition may be in a form suitable for oral administration, for example as a tablet or capsule, for parenteral injection (including intravenous, subcutaneous, intramuscular, intravascular or infusion) for example as a sterile solution, suspension or emulsion, for topical administration for example as an ointment or cream or for rectal administration for example as a suppository, hi general the above compositions may be prepared in a conventional manner using conventional excipients. The compositions ofthe present invention are advantageously presented in unit dosage form. The compound will normally be administered to a warm-blooded animal at a unit dose within the range 5-5000mg per square metre body area ofthe animal, i.e. approximately 0.1-100mg/kg. A unit dose in the range, for example, 1-lOOmg/kg, preferably l-50mg/kg is envisaged and this normally provides a therapeutically-effective dose. A unit dose form such as a tablet or capsule will usually contain, for example l-250mg of active ingredient. According to a further aspect ofthe present invention there is provided a compound ofthe formula I or a pharmaceutically acceptable salt thereof as defined hereinbefore for use in a method of treatment ofthe human or animal body by therapy. We have found that compounds ofthe present invention inhibit VEGF receptor tyrosine kinase activity and are therefore of interest for their antiangiogenic effects and/or their ability to cause a reduction in vascular permeability. A further feature ofthe present invention is a compound of formula I, or a pharmaceutically acceptable salt thereof, for use as a medicament, conveniently a compound of formula I, or a pharmaceutically acceptable salt thereof, for use as a medicament for producing an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human being. Thus according to a further aspect ofthe invention there is provided the use of a compound ofthe formula I, or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human being. According to a further feature ofthe invention there is provided a method for producing an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal, such as a human being, in need of such treatment which comprises administering to said animal an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof as defined hereinbefore. As stated above the size ofthe dose required for the therapeutic or prophylactic treatment of a particular disease state will necessarily be varied depending on the host treated, the route of administration and the severity ofthe illness being treated. Preferably a daily dose in the range of l-50mg/kg is employed. However the daily dose will necessarily be varied depending upon the host treated, the particular route of administration, and the severity ofthe illness being treated. Accordingly the optimum dosage may be determined by the practitioner who is treating any particular patient. The antiangiogenic and/or vascular peπneability reducing treatment defined hereinbefore may be applied as a sole therapy or may involve, in addition to a compound of the invention, one or more other substances and/or treatments. Such conjoint treatment may be achieved by way ofthe simultaneous, sequential or separate administration ofthe individual components ofthe treatment. In the field of medical oncology it is normal practice to use a combination of different forms of treatment to treat each patient with cancer. In medical oncology the other component(s) of such conjoint treatment in addition to the antiangiogenic and/or vascular permeability reducing treatment defined hereinbefore may be: surgery, radiotherapy or chemotherapy. Such chemotherapy may cover three main categories of therapeutic agent: (i) other antiangiogenic agents that work by different mechanisms from those defined hereinbefore (for example linomide, inhibitors of integrin αvβ3 function, angiostatin, razoxin, thalidomide), and including vascular targeting agents (for example combretastatin phosphate and the vascular damaging agents described in International Patent Application Publication No. WO 99/02166 the entire disclosure of which document is incoφorated herein by reference, (for example N-acetylcolchinol-O-phosphate), and in International Patent Application Publication No. WO 00/40529 the entire disclosure of which document is incoφorated herein by reference); (ii) cytostatic agents such as antioestrogens (for example tamoxifen,toremifene, raloxifene, droloxifene, iodoxyfene), progestogens (for example megestrol acetate), aromatase inhibitors (for example anastrozole, letiazole, vorazole, exemestane), antiprogestogens, antiandrogens (for example flutamide, nilutamide, bicalutamide, cyproterone acetate), LHRH agonists and antagonists (for example goserelin acetate, luprolide), inhibitors of testosterone 5α- dihydroreductase (for example finasteride), anti-invasion agents (for example metalloproteinase inhibitors like marimastat and inhibitors of urokinase plasminogen activator receptor function) and inhibitors of growth factor function, (such growth factors include for example platelet derived growth factor and hepatocyte growth factor such inhibitors include growth factor antibodies, growth factor receptor antibodies, tyrosine kinase inhibitors and serine/threonine kinase inhibitors); and (iii) antiproliferative/antineoplastic drugs and combinations thereof, as used in medical oncology, such as antimetabolites (for example antifolates like methotrexate, fluoropyrimidines like 5-fluorouracil, purine and adenosine analogues, cytosine arabinoside); antitumour antibiotics (for example anthracyclines like doxorubicin, daunomycin, epirubicin and idarubicin, mitomycin-C, dactinomycin, mithramycin); platinum derivatives (for example cisplatin, carboplatin); alkylating agents (for example nitrogen mustard, melphalan, chlorambucil, busulphan, cyclophosphamide, ifosfamide, nitrosoureas, thiotepa); antimitotic agents (for example vinca alkaloids like vincristine and taxoids like taxol, taxotere); topoisomerase inhibitors (for example epipodophyllotoxins like etoposide and teniposide, amsacrine, topotecan, and also irinotecan); also enzymes (for example asparaginase); and thymidylate synthase inhibitors (for example raltitrexed); and additional types of chemotherapeutic agent include: (iv) biological response modifiers (for example interferon); and (v) antibodies (for example edrecolomab). For example such conjoint treatment may be achieved by way ofthe simultaneous, sequential or separate administration of a compound of formula I as defined hereinbefore, and a vascular targeting agent described in WO 99/02166 such as N-acetylcolchinol-O-phosphate (Exampe 1 of WO 99/02166). As stated above the compounds defined in the present invention are of interest for their antiangiogenic and/or vascular permeability reducing effects. Such compounds ofthe invention are expected to be useful in a wide range of disease states including cancer, diabetes, psoriasis, rheumatoid arthritis, Kaposi's sarcoma, haemangioma, acute and chronic nephropathies, atheroma, arterial restenosis, autoimmune diseases, acute inflammation, excessive scar formation and adhesions, lymphoedema, endometriosis, dysfunctional uterine bleeding and ocular diseases with retinal vessel proliferation. In particular such compounds of the invention are expected to slow advantageously the growth of primary and recurrent solid tumours of, for example, the colon, breast, prostate, lungs and skin. More particularly such compounds ofthe invention are expected to inhibit the growth of those primary and recurrent solid tumours which are associated with VEGF, especially those tumours which are significantly dependent on VEGF for their growth and spread, including for example, certain tumours ofthe colon, breast, prostate, lung, vulva and skin. In addition to their use in therapeutic medicine, the compounds of formula I and their pharmaceutically acceptable salts are also useful as pharmacological tools in the development and standardisation of in vitro and in vivo test systems for the evaluation ofthe effects of inhibitors of VEGF receptor tyrosine kinase activity in laboratory animals such as cats, dogs, rabbits, monkeys, rats and mice, as part ofthe search for new therapeutic agents. It is to be understood that where the term "ether" is used anywhere in this specification it refers to diethyl ether. The invention will now be illustrated in the following non-limiting Examples in which, unless otherwise stated:- (i) evaporations were caπied out by rotary evaporation in vacuo and work-up procedures were carried out after removal of residual solids such as drying agents by filtration; (ii) operations were carried out at ambient temperature, that is in the range 18-25°C and under an atmosphere of an inert gas such as argon; (iii) column chromatography (by the flash procedure) and medium pressure liquid chromatography (MPLC) were performed on Merck Kieselgel silica (Art. 9385) or Merck Lichroprep RP-18 (Art. 9303) reversed-phase silica obtained from E. Merck, Darmstadt, Germany; (iv) yields are given for illustration only and are not necessarily the maximum attainable; (v) melting points are uncoπected and were determined using a Mettler SP62 automatic melting point apparatus, an oil-bath apparatus or a Koffler hot plate apparatus. (vi) the structures ofthe end-products ofthe formula I were confirmed by nuclear (generally proton) magnetic resonance (NMR) and mass spectral techniques; proton magnetic resonance chemical shift values were measured on the delta scale and peak multiplicities are shown as follows: s, singlet; d, doublet; t, triplet; m, multiplet; br, broad; q, quartet, quin, quintet; (vii) intermediates were not generally fully characterised and purity was assessed by thin layer chromatography (TLC), high-perfoπnance liquid chromatography (HPLC), infra-red (TR) or NMR analysis; (viii) HPLC were run under 2 different conditions: 1) on a TSK Gel super ODS 2μM 4.6mm x 5cm column, eluting with a gradient of methanol in water (containing 1% acetic acid) 20 to 100% in 5 minutes. Flow rate 1.4 ml/minute. Detection: U.V. at 254 nm and light scattering detections; 2) on a TSK Gel super ODS 2μM 4.6mm x 5cm column, eluting with a gradient of methanol in water (containing 1% acetic acid) 0 to 100% in 7 minutes. Flow rate 1.4 ml/minute. Detection: U.V. at 254 nm and light scattering detections. (ix) petroleum ether refers to that fraction boiling between 40-60°C (x) the following abbreviations have been used:- DMF N,N-dimethylformamide DMSO dimethylsulphoxide TFA trifluoroacetic acid NMP l-methyl-2-pyπolidinone THF tetrahydrofuran HMDS 1,1,1,3,3,3-hexamethyldisilazane. HPLC RT HPLC retention time DEAD diethyl azodicarboxylate DMA dimethylacetamide DMAP 4-dimethylaminopyridine Example 1 Under nitrogen a suspension of l-chloiO-4-(4-pyridylmethyl)phthalazine (150 mg, 0.58 mmol), (J. Med. Chem. 2000, 43, 2310-2323), 4-fluoro-5-hydroxyindole (106 mg, 0.7 mmol) and cesium carbonate (306 mg, 0.938 mmol) in DMF (5.5 ml) was heated at 95°C for 2 hours. The volatiles were removed under vacuum and the residue was purified by column chromatography eluting with methylene chloride followed by methylene chloride/ethyl acetate/methanol (45/50/5 followed by 40/50/10). The fractions containing the expected product were combined and evaporated to give l-(4-fluoroindol-5-yloxy)-4-(4- pyridylmethyl)phthalazine (57 mg, 22 %). 1H NMR Spectrum: (DMSOd 6 ) 4.66 (s, 2H) ; 6.57 (s, IH) ; 7.15 (dd, IH) ; 7.35 (m, 3H) ; 7.5 (m, IH) ; 8.12 (m, 2H) ; 8.3 (m, IH) ; 8.48 (d, 2H) ; 8.5 (m, IH) The starting material was prepared as follows: A mixture of 2-fluoro-4-nitrophenol (15g, 95.5 mmol) and benzyl bromide (18g, 105 mmol) in acetone (125 ml) containing potassium carbonate (26.5 g, 190 mmol) was heated at reflux for 2 hours. The volatiles were removed and the residue was partitioned between 2N hydrochloric acid and ethyl acetate. The organic layer was separated, washed with water, brine, dried (MgSO 4 ) and the volatiles were removed under vacuum. The solid was triturated with petroleum ether to give 2-fluoro-4-nitio-benzyloxybenzene (23g, 97%). 1H NMR Spectrum: (CDC1 3 ) 5.3 (s, 2H) ; 7.1 (t, IH) ; 7.35-7.55 (m, 5H) ; 8.0( m, 2H) To a solution of potassium tert-butoxide (1.72g, 15.4 mmol) in DMF (15 ml) cooled at -30°C, was added dropwise a solution of 2-fluoro-4-nitro-benzyloxybenzene (1.73g, 7 mmol) and 4-chlorophenoxyacetonitrile (1.29 g, 7.7 mmol) while maintaining the temperature below -25°C. After completion of addition, the mixture was stiπed for 30 minutes at -20°C and then poured onto a mixture of cold IN hydrochloric acid and ether. The organic layer was separated, washed with IN sodium hydroxide, followed by water, brine and dried (MgSO 4 ). The volatiles were removed under vacuum and the residue was purified by column chromatography eluting with methylene chloride/petroleum ether (3/1) to give a mixture of 3- cyanomethyl-2-fluoro-4-nitrobenzyloxybenzene and 5-cyanomethyl-2-fluoro-4- nitrobenzyloxybenzene (1.2 g, 60%). 1H NMR Spectrum: (DMSOd 6 ) 4.22 (s, 2H, 3-cyanomethyl isomer) ; 4.3 (s, 2H, 5- cyanomethyl isomer); 5.32 (s, 2H, 5-cyanomethyl isomer) ; 5.36 (s, 2H, 3-cyanomethyl isomer); 7.3-7.7 (m, 6H); 8.1 (d, IH, 3-cyanomethyl isomer); 8.2 (d, IH, 5-cyanomethyl isomer) A solution of a mixture of 3-cyanomethyl-2-fluoro-4-nitrobenzyloxybenzene and 5- cyanomethyl-2-fluoro-4-nitrobenzyloxybenzene (23g, 80.4 mmol) in ethanol (220ml) and acetic acid (30ml) containing 10% palladium on charcoal (600mg) was hydrogenated under 3 atmospheres pressure until hydrogen uptake ceased. The mixture was filtered and the filtrate was evaporated under vacuum. The residue was purified on column chromatography using a Prochrom® equipment eluting with methylene chloride/petroleum ether (20/80) to give 4- fluoro-5-hydroxyindole (2.48g) and 6-fluoro-5-hydroxyindole (3.5 g). 4-fluoro-5-hydroxyindole: 1H MR Spectrum: (DMSOd 6 ) 6.32 (s, IH) ; 6.75 (dd, IH) ; 7.0 (d, IH) ; 7.28 (dd, IH) ; 8.8 (br s, IH) ; 11.05 (br s, IH) 6-fluoro-5-hydroxyindole: 1H NMR Spectrum: (DMSOd 6 ) 6.25 (s, IH) ; 7.0 (d, IH) ; 7.12 (d, IH) ; 7.2 (dd, IH) ; 9.0 (br s, lH) Examples 2-8 Using an analogous procedure to that described in Example 1, l-chloro-4-(4- pyridylmethyl)phthalazine (150 mg) was reacted with the appropriate hydroxyindole (0.7 mmol) to give the corresponding compounds described in Table I: Table I a) l-Chloro-4-(4-pyridylmethyl)phthalazine (150 mg) was reacted with 6-fluoro-5- hydroxyindole (106 mg, 0.7 mmol), (prepared as described for the starting material in Example 1), to give l-(6-fluoromdol-5-yloxy)-4-(4-pyridylmethyI)phthalazine. 1H NMR Spectrum: (DMSOd 6 ) 4.65 (s, 2H) ; 6.5 (s, 2H) ; 7.32 (d, 2H) ; 7.4 (d, IH) ; 7.45 (s, IH) ; 7.62 (d, IH) ; 8.1 (m, 2H) ; 8.3 (m, IH) ; 8.48 (d, 2H) ; 8.5 (m, IH) b) l-Chloro-4-(4-pyridylmethyl)phthalazine (150 mg) was reacted with 5-hydroxy-2- methylindole (104 mg, 0.7 mmol) to give l-(2-methyIindoI-5-yloxy)-4-(4- pyridylmethyl)plιthalazine. 1H NMR Spectrum: (DMSOd 6 ) 2.42 (s, 3H) ; 4.65 (s, 2H) ; 6.18 (s, IH) ; 6.95 (dd, IH) ; 7.32 (m, 4H) ; 8.1 (m, 2H) ; 8.25 (m, IH) ; 8.48 (m, 3H) c) l-Chloro-4-(4-pyridylmethyl)phthalazine (150 mg) was reacted with 5-hydroxyindole (94 mg, 0.7 mmol) to give l-(indol-5-yloxy)-4-(4-pyridylmethyl)phthaIazine. 1H NMR Spectrum: (DMSOd 6 ) 4.65 (s, 2H) ; 6.48 (s, IH) ; 7.05 (dd, IH) ; 7.32 (d, 2H) ; 7.4-7.5 (m, 3H) ; 8.07 (m, 2H) ; 8.25 (m, IH) ; 8.4-8.5 (m, 3H) d) l-Chloro-4-(4-pyridylmethyl)phthalazine (150 mg) was reacted with 6-hydroxyindole (94 mg, 0.7 mmol) to give l-(indol-6-yloxy)-4-(4-pyridylmethyl)phthaIazine. 1H NMR Spectrum: (DMSOd 6 ) 4.65 (s, 2H) ; 6.5 (s, IH) ; 6.98 (dd, IH) ; 7.35 (d, 2H) ; 7.37 (s, IH) ; 7.4 (m, IH) ; 7.6 (d, IH) ; 8.1 (m, 2H) ; 8.28 (m, IH) ; 8.4-8.5 (m, 3H) e) l-Chloro-4-(4-pyridylmethyl)phthalazine (150 mg) was reacted with 6-hydroxy-2- methylindole (104 mg, 0.7 mmol), (Eur. J. Med. Chem. 1975, 10, 187), to give l-(2- methylindol-6-yloxy)-4-(4-pyridylmethyl)phthalazine. 1H NMR Spectrum: (DMSOd 6 ) 2.41 (s, 3H) ; 4.65 (s, 2H) ; 6.18 (s, IH) ; 6.9 (dd, IH) ; 7.21 (s, IH) ; 7.32 (d, 2H) ; 7.45 (d, IH) ; 8.05-8.15 (m, 2H) ; 8.25 (m, IH) ; 8.4-8.5 (m, 3H) f) l-Chloro-4-(4-pyridylmethyl)phthalazine (150 mg) was reacted with 2,3-dimethyl-5- hydroxyindole (113 mg, 0.7 mmol), (Arch. Pharm. 1972, 305, 159), to give l-(2,3- dimethylindol-5-yloxy)-4-(4-pyridylmethyl)phthalazine. 1H NMR Spectrum: (DMSOd 6 ) 2.15 (s, 3H) ; 2.35 (s, 3H) ; 4.65 (s, 2H) ; 6.93 (dd, IH) ; 7.2-7.4 (m, ATT) ; 8.0-8.12 (m, 2H) ; 8.25 (m, IH) ; 8.4-8.5 (m, 3H) g) l-Chloro-4-(4-pyridylmethyl)phthalazine (150 mg) was reacted with l,2-dimethyl-5- hydroxyindole (113 mg, 0.7 mmol), (Tetrahedron, 1994, 50, 13433), to give 1-(1,2- dimetkyImdol-5-yloxy)-4-(4-pyridyImethyI)phthaIazine. 1H NMR Spectrum: (DMSOd 6 ) 2.45 (s, 3H) ; 3.72 (s, 3H) ; 4.64 (s, 2H) ; 6.25 (s, IH) ; 7.03 (dd, IH) ; 7.32 (d, 2H) ; 7.35 (s, IH) ; 7.46 (d, IH) ; 8.02-8.1 (m, 2H) ; 8.25 (m, IH) 8.46 (m, 3H) Example 9 11 15 12 Using an analogous procedure to that described in Example 1, 4-chlorothieno[3,2-d]pyrimidine (150 mg, 0.88 mmol) was reacted with 4-fluoro-5-hydroxy- 2-methylindole (174 mg, 1.05 mmol) to give 4-(4-fluoro-2-methylindol-5-yIoxy)thieno[3,2-d]pyrimidine (18 mg, 7 %). 1H NMR Spectrum: (DMSOd 6 ) 2.41 (s, 3H) ; 6.25 (s, IH) ; 7.03 (dd, IH) ; 7.18 (d, IH) ; 7.7 (d, IH) ; 8.5 (d, IH) ; 8.68 (s, IH) MS - ESI: 300 [MH] + The starting material was prepared as follows : To a suspension of sodium hydride (5.42 g, 226 mmol) (prewashed with pentane) in THF (100 ml) cooled at 10°C was added ethyl acetoacetate (29.4 g, 226 mmol) while keeping the temperature below 15°C. After completion of addition, the mixture was further stiπed for 15 minutes and cooled to 5°C. A solution of l,2,3-trifluoro-4-nitrobenzene (20 g, 113 mmol) in THF (150 ml) was added while keeping the temperature below 5°C. The mixture was then left to warm up to ambient temperature and stiπed for 24 hours. The volatiles were removed under vacuum and the residue was partitioned between ethyl acetate and 2N aqueous hydrochloric acid. The organic layer was washed with water, brine, dried (MgSO ) and evaporated. The residue was dissolved in concentrated hydrochloric acid (650 ml) and acetic acid (600 ml) and the mixture was heated at reflux for 15 hours. After cooling, the volatiles were removed under vacuum and the residue was partitioned between aqueous sodium hydrogen carbonate (5 %) and ethyl acetate. The organic layer was washed with sodium hydrogen carbonate, water, brine, dried (MgSO 4 ) and evaporated. The residue was purified by column chromatography eluting with ethyl acetate/petroleum ether (75/25) to give 3- acetylmethyl-l,2-difluoro-4-nitrobenzene (17.5 g, 72 %). 1H NMR Spectrum: (CDC1 3 ) 2.4 (s, 3H) ; 4.25 (s, 2H) ; 7.25 (dd, IH) ; 8.0 (dd, IH) A solution of 3-acetylmethyl-l,2-difluoro-4-nitrobenzene (500 mg, 2.3 mmol) in methylene chloride (5 ml) containing montmorillonite K10 (1 g) and trimethyl orthoformate (5 ml) was stiπed for 24 hours at ambient temperature. The solid was filtered, washed with methylene chloride and the filtrate was evaporated to give l,2-difluoro-3-(2,2- dimethoxypropyl)-4-nifrobenzene (534 mg, 88 %). 1H NMR Spectrum: (CDC1 3 ) 1.2 (s, 3H) ; 3.2 (s, 6H) ; 3.52 (s, 2H) ; 7.18 (dd, IH) ; 7.6 (m, IH) To a solution of benzyl alcohol (221 mg, 2.05 mmol) in DMA (1.5 ml) was added 60% sodium hydride (82 mg, 2.05 mmol). The mixture was stiπed for 1 hour at ambient temperature. A solution of l,2-difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene (534 mg, 2.05 mmol) in DMA (1.5 ml) was added and the mixture was stiπed for 3 hours at ambient 5 temperature. The mixture was diluted with IN hydrochloric acid (10 ml) and extracted with ethyl acetate. The organic layer was evaporated and the residue was dissolved in THF (2 ml) and 6N hydrochloric acid (0.3 ml) was added. The mixture was stiπed for 1 hour at ambient temperature and the solvents were removed under vacuum. The residue was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine, dried 10 (MgSO 4 ) and evaporated. The solid was triturated with ether, filtered, washed with ether and dried under vacuum to give 3-acetylmethyl-l-benzyloxy-2-fluoro-4-nitrobenzene (350 mg, 56 %). 1H NMR Spectrum: (CDC1 3 ) 2.35 (s, 3H) ; 4.25 (s, 2H) ; 5.25 (s, 2H) ; 7.0 (dd, IH) ; 7.32-7.5 (m, 5H) ; 8.0 (dd, IH) 15 A solution of 3-acetylmethyl-l-benzyloxy-2-fluoro-4-nitrobenzene (300 mg, 0.99 mmol) in ethanol (10 ml) and acetic acid (1 ml) containing 10 % palladium on charcoal (30 mg) was hydrogenated at 2 atmospheres pressure for 2 hours. The mixture was filtered and the filtrate was evaporated. The residue was dissolved in ethyl acetate and the organic layer was washed with aqueous sodium hydrogen carbonate, brine and evaporated to give 4-fluoro- 20 5-hydroxy-2-methylindole. The residue was purified by column chromatography eluting with ethyl acetate/petroleum ether (3/7) to give 4-fluoro-5-hydroxy-2-methylindole (63 mg, 30%). MS-ESI : 166 [MH] + 1H NMR Spectrum: (DMSOd 6 ) 2.35 (s, 3H) ; 6.05 (s, IH) ; 6.65 (dd, IH) ; 6.9 (d, IH) ; 8.75 (s, IH) ; 10.9 (s, IH) 25 13 C NMR Spectrum: (DMSOdg) 13.5 ; 94,0 ; 106,0 ; 112 ; 118.5 (d) ; 132 (d) ; 136 (d) ; 136.5 ; 142.5 (d) Alternatively the 4-fluoro-5-hydroxy-2-methylindole maybe prepared as follows: To a solution of 2-fluoro-4-nitroanisole (9.9 g, 58 mmol) and 4- 30 chlorophenoxyacetonitrile (10.7 g, 64 mmol) in DMF (50 ml) cooled at -15°C was added potassium tert-butoxide (14.3 g, 127 mmol) in DMF (124 ml). After stirring for 30 minutes at -15°C, the mixture was poured onto cooled IN hydrochloric acid. The mixture was extracted with ethyl acetate. The organic layer was washed with IN sodium hydroxide, brine, dried (MgSO 4 ) and evaporated. The residue was purified by column chromatography eluting with methylene chloride. The fractions containing the expected product were combined and evaporated. The residue was dissolved in ethanol (180 ml) and acetic acid (24 ml) containing 10 % palladium on charcoal (600 mg) and the mixture was hydrogenated under 3 atmospheres pressure for 2 hours. The mixture was filtered, and the volatiles were removed under vacuum. The residue was partitioned between ethyl acetate and water. The organic layer was separated, and washed with saturated sodium hydrogen carbonate followed by brine, dried (MgSO 4 ) and evaporated. The residue was purified by column chromatography eluting with methylene chloride to give a mixture of 4-fluoro-5-methoxyindole and 6-fluoro-5- methoxyindole (5.64 g, 59 %) in a ratio 1/2. 1H NMR Spectrum: (DMSOd 6 ) 3.85 (s, 3H) ; 6.38 (s, IH, 6-Fluoro) ; 6.45 (s, IH ; 4-Fluoro) ; 6.9-7.4 ( , 3H) A solution of 4-fluoro-5-methoxyindole and 6-fluoro-5-methoxyindole in a ratio 1/2 (496 mg, 3 mmol), di-tertbutyl dicarbonate (720 mg, 3.3 mmol) in acetonitrile (12 ml) containing DMAP (18 mg, 0.15 mmol) was stiπed at ambient temperature for 24 hours. The volatiles were removed under vacuum. The residue was dissolved in ethyl acetate, washed with IN hydrochloric acid, followed by water, brine, dried (MgSO 4 ) and evaporated to give a mixture of 4-fluoro-5-methoxy-l-tert-butoxycarbonylindole and 6-fluoro-5-methoxy-l-tert- butoxycarbonylindole in a ratio 1/2 (702 mg, 88 %). 1H NMR Spectrum: (DMSOd 6 ) 1.65 (s, 9H) ; 3.9 (s, 3H) ; 6.6 (d, IH, 6-fluoro) ; 6.72 (d, IH, 4-fluoro) ; 7.2 (t, IH, 6-fluoro) ; 7.4 (d, IH, 4-fluoro) ; 7.62 (d, IH, 6-fluoro) ; 7.68 (d, IH, 4- fluoro) ; 7.78 (s, IH, 4-fluoro) ; 7.85 (s, IH, 6-fluoro) To a solution of 4-fluoro-5-methoxy-l-tert-butoxycarbonylindole and 6-fluoro-5- methoxy-1-tert-butoxycarbonylindole in a ratio 1/2 (8.1 g, 30.5 mmol) in THF (100 ml) cooled at -65°C was added tert-butyllithium (1.7 M) (23 ml, 35.7 mmol). After stirring for 4 hours at -70°C, methyl iodide (8.66 g, 61 mmol) was added and the mixture was left to warm- up to ambient temperature. Water was added and the mixture was extracted with ether. The organic layer was washed with water, brine, dried (MgSO 4 ) and evaporated and was used directly in the next step . The crude product was dissolved in methylene chloride (100 ml) and TFA (25 ml) was added. After stiπing for 1 hour at ambient temperature, the volatiles were removed under vacuum. The residue was dissolved in ethyl acetate and the organic layer was washed with IN sodium hydroxide, followed by water, brine, dried (MgSO 4 ) and evaporated. The residue was purified by column chromatography, eluting with ethyl acetate/petroleum ether (3/7) to give 6-fluoro-5-methoxy-2-methylindole (1.6 g) and 4-fluoro-5-methoxy-2-methylindole (0.8 5 g, 48 %). 6-fluoro-5-methoxy-2-methylindole: MS-ESI : 180 [MH] + 1H NMR Spectrum: (DMSOd 6 ) 2.35 (s, 3H) ; 3.8 (s, 3H) ; 6.05 (s, IH) ; 7.1 (s, IH) ; 7.12 (s, IH) ; 10.8 (s, IH) 10 4-fluoro-5-methoxy-2-methylindole: MS-ESI : 180 [MH] + 1H NMR Spectrum: (DMSOd 6 ) 2.35 (s, 3H) ; 3.8 (s, 3H) ; 6.15 (s, IH) ; 6.9 (t, IH) ; 7.05 (d, lH) ; 11.0 (s, IH) To a solution of 4-fluoro-5-methoxy-2-methylindole (709 mg, 3.95 mmol) in 15 methylene chloride (9 ml) cooled at -30°C was added a solution of boron tribromide (2.18 g, 8.7 mmol) in methylene chloride (1 ml). After stirring for 1 hour at ambient temperature, the mixture was poured onto water and was diluted with methylene chloride. The pH ofthe aqueous layer was adjusted to 6. The organic layer was separated, washed with water, brine, dried (MgSO ) and evaporated. The residue was purified by column chromatography, eluting 20 with ethyl acetate/petroleum ether (3/7) to give 4-fluoro-5-hydroxy-2-methylindole (461 mg, 70 %). MS-ESI : 166 [MH] + 1 H NMR Spectrum: (DMSOd 6 ) 2.35 (s, 3H) ; 6.05 (s, IH) ; 6.65 (dd, IH) ; 6.9 (d, IH) ; 8.75 (s, IH) ; 10.9 (s, IH) 25 13 C NMR Spectrum: (DMSOd 6 ) 13.5 ; 94,0 ; 106,0 ; 112 ; 118.5 (d) ; 132 (d) ; 136 (d) ; 136.5 ; 142.5 (d) Alternatively the 4-fluoro-5-hydroxy-2-methylindole maybe prepared as follows: A solution of sodium methoxide (freshly prepared from sodium (1.71g) and methanol 30 (35ml)) was added to a solution of l,2-difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene (16.2 g, 62 mmol), (prepared as described above), in methanol (200ml) cooled at 5°C. The mixture was left to warm to ambient temperature and was stiπed for 3 days. The volatiles were removed under vacuum and the residue was partitioned between ethyl acetate and 2N hydrochloric acid (1ml). The organic layer was concentrated to a total volume of 100ml and THF (100ml) and 6N hydrochloric acid (25ml) were added. The mixture was stiπed for 1 hour at ambient temperature. The volatiles were removed under vacuum and the residue was 5 partitioned between ethyl acetate and water. The organic layer was separated, washed with water, brine, dried (MgSO 4 ) and evaporated. The residue was purified by column chromatography eluting with ethyl acetate/petroleum ether (3/7) to give 3-acetylmethyl-2- fluoro-l-methoxy-4-nitrobenzene (12.7 g, 90%). MS-ESI : 250 [MNa]+ 10 1H NMR Spectrum: (CDCI 3 ) 2.38 (s, 3H) ; 4.0 (s, 3H) ; 4.25 (s, 2H) ; 7.0 (dd, IH) ; 8.05 (d, IH) To a solution of 3-acetylmethyl-2-fluoro-l-methoxy-4-nitrobenzene (11.36g, 50 mmol) in acetone (200ml) was added 4M aqueous ammonium acetate (700ml) followed by a solution of titanium trichloride (15% in water, 340ml) dropwise. The mixture was stiπed for 15 10 minutes at ambient temperature and the mixture was extracted with ether. The organic layer was washed with 0.5N aqueous sodium hydroxide followed by water, brine, dried (MgSO 4 ) and the volatiles were removed under vacuum. The residue was purified by column chromatography eluting with methylene chloride to give 4-fluoro-5-methoxy-2-methylindole (8.15g, 90%). 20 1H NMR Spectrum: (DMSO) 2.35 (s, 3H) ; 3.8 (s, 3H) ; 6.1 (s, IH) ; 6.85 (dd, IH) ; 7.02 (d, IH) Cleavage of 4-fluoro-5-methoxy-2-methylindole with boron tribromide to give 4- fluoro-5-hydroxy-2-methylindole is described above. 25 Example 10 To a solution of l-chloro-4-(4-pyridylmethyl)phthalazine (85 mg, 0.33 mmol), (J. Med. Chem. 2000, 43, 2310-2323), and 5-aminoindole (53 mg, 0.39 mmol) in isopropanol (5 ml) was added 5.5N HCl in isopropanol (70 μl). After stirring for 4 hours at 85°C, the solid was filtered, washed with isopropanol followed by ether and dried under vacuum to give 1- (mdol-5-ylamino)-4-(4-pyridylmethyl)phthalazine hydrochloride (52 mg, 37 %). 1H NMR Spectrum: (DMSO d 6 ) 4.6 (s, 2H) ; 6.55 (s, IH) ; 7.25 (dd, IH) ; 7.42 (d, 2H) ; 7.48 (t, IH) ; 7.58 (d, IH) ; 7.78 (s, IH) ; 8.18 (m, 2H) ; 8.3 (m, IH) ; 8.52 (d, 2H) ; 9.0 (m, 1) MS - ESI: 352 [MH] + Example 11 Under nitrogen a solution of l-chloro-4-(4-pyridylmethyl)phthalazine (160 mg, 0.62 mmol), (J. Med. Chem. 2000, 43, 2310-2323), 4-fluoro-5-hydroxy-2-methyIindole (124 mg, 0.75 mmol), (prepared as described for the starting material in Example 9), and cesium carbonate (408 mg, 1.2 mmol) in DMF ( 4 ml) was heated at 95°C for 1.5 hours. After cooling, the mixture was filtered and the volatiles were removed under vacuum. The residue was purified by column chromatography, eluting with methylene chloride, followed by methylene chloride/ethyl acetate/methanol (45/50/5). The fractions containing the expected product were combined and evaporated. The residue was triturated with ether, and the solid was filtered, washed with ether and dried under vacuum to give l-(4-fluoro-2-methylindol-5- yloxy)-4-(4-pyridylmethyl)phthalazine (98 mg, 41 %). 1H NMR Spectrum: (CDC1 3 ) 2.42 (s, 3H) ; 4.61 (s, 2H) ; 6.28 (s, IH) ; 7.02 (s, IH) ; 7.04 (d, IH) ; 7.24 (d, 2H) ; 7.8-8.0 (m, 3H) ; 8.3 (br s, IH) ; 8.49 (d, 2H) ; 8.54 (d, IH) MS - ESI: 385 [MH] + Example 12 The following illustrate representative pharmaceutical dosage forms containing the compound of formula I, or a pharmaceutically acceptable salt thereof (hereafter compound X), for therapeutic or prophylactic use in humans: (a) Tablet I mg/tablet Compound X 100 Lactose Ph.Eur 182.75 Croscarmellose sodium 12.0 Maize starch paste (5% w/v paste) 2.25 Magnesium stearate 3.0 (b) Tablet II mg/tablet Compound X 50 Lactose Ph.Eur 223.75 Croscarmellose sodium 6.0 Maize starch 15.0 Polyvinylpyrrolidone (5% w/v paste) 2.25 Magnesium stearate 3.0 (c) Tablet mg/tablet Compound X 1.0 Lactose Ph.Eur 93.25 Croscannellose sodium 4.0 Maize starch paste (5% w/v paste) 0.75 Magnesium stearate 1.0 (d) Capsule mg/capsule Compound X 10 Lactose Ph.Eur 488.5 Magnesium stearate 1.5 (e) hijection l (50 mg/ml) Compound X 5.0% w/v IN Sodium hydroxide solution 15.0% v/v 0.1N Hydrochloric acid (to adjust pH to 7.6) Polyethylene glycol 400 4.5% w/v Water for injection to 100% (f) Injection II 10 mg/ml) Compound X 1.0% w/v Sodium phosphate BP 3.6% w/v 0.1N Sodium hydroxide solution 15.0% v/v Water for injection to 100% (g) Injection HI (lmg/ml.buffered to pH6) Compound X 0.1% w/v Sodium phosphate BP 2.26% w/v Citric acid 0.38% w/v Polyethylene glycol 400 3.5% w/v Water for injection to 100% Note The above fonnulations may be obtained by conventional procedures well known in the pharmaceutical art. The tablets (a)-(c) may be enteric coated by conventional means, for example to provide a coating of cellulose acetate phthalate. Reference Example 1 2-methyl-l_ff-pyrroIo[2,3-Z>]pyridin-5-ol To a solution of 5-methoxy-lH-pyπolo[2,3-/3]pyridine (920 mg, 6.2 mmol) (Heterocycles 50, (2) 1065-1080, 1999) in methylene chloride (20ml) was added benzyltriethylammonium chloride (37 mg, 0.16 mmol) followed by sodium hydroxide powder (771 mg, 19.2 mmol). The mixture was cooled to 0°C and benzylsulfonyl chloride (991 μl, 7.77 mmol) was added dropwise. The mixture was stiπed at 0°C for 15 minutes followed by 2 hours at ambient temperature. The mixture was filtered over diatomaceous earth and the filtrate was evaporated under vacuum. The residue was purified by column chromatography eluting with ethyl acetate/petroleum ether (20/80 followed by 30/70). The fractions containing the expected product were combined and evaporated to give 5-methoxy-l- (phenylsulfonyl)-lH-pyπolo[2,3-6]pyridine (1.69 g ; 94%) 1H NMR Spectrum: (DMSO d 6 ) 3.86 (s, 3H) ; 6.78 (d, IH) ; 7.6-7.7 (m, 3H) ; 7.72 (dd, IH) ; 7.88 (d, IH) ; 8.02-8.12 (m, 3H) MS: 289.47 [M+H]+ A solution of 5-methoxy-l-(phenylsulfonyl)-lH-pyπolo[2,3-6]pyridine (900 mg, 3.12 mmol) in THF (22.5 ml) was added dropwise to a solution of lithium diisopropylamide (prepared from nBu-Li (2.5M in hexane) ; 2.5 ml) and diisopropylamine (874 μl) in THF (13.5 ml)) cooled at -25°C and the mixture was stiπed for 30 minutes. Methyl iodide (215 μl, 3.44 mmol) in THF (9 ml) was then added dropwise and the mixture was stiπed for 10 minutes at -25°C, left to waπn up to ambient temperature and stiπed for 15 minutes. The mixture was then poured onto ice/water. The mixture was then extracted with ethyl acetate. The organic layer was separated, washed with water, brine, dried (MgSO 4 ), filtered and evaporated. The residue was purified by column chromatography, eluting with ethyl acetate/petroleum ether (20/80 followed by 30/70). The fractions containing the expected product were combined and evaporated to give 5-methoxy-2-methyl-l-(phenylsulfonyl)-lH- pyπolo[2,3-b]ρyridine (805 mg, 85%). 1H NMR Spectrum: (DMSOd 6 ) 2.7 (s, 3H) ; 3.82 (s, 3H) ; 6.51 (d, IH) ; 7.49 (d, IH) ; 7.59 (dd, 2H) ;7.7 (m, IH) ; 8.0-8.1 (m, 3H) MS: 303.5 [M+H]+ A solution of 5-methoxy-2-methyl-l-(phenylsulfonyl)-lH-pyrrolo[2,3-&]pyridine (950 mg, 3.14 mmol) and 40% aqueous sodium hydroxyde (106 ml) in methanol (160 ml) was heated at reflux for 30 minutes. After cooling, the mixture was poured onto cooled water and extiacted with ethyl acetate. The organic layer was separated, washed with water, brine, dried (MgSO ), filtered and evaporated. The residue was purified by column chromatography eluting with ethyl acetate/petroleum ether (1/1). The fractions containing the expected product were combined and evaporated to give 5-methoxy-2-methyl-lH-pyπolo[2,3- b]pyridine (462 mg, 91%). 1H NMR Spectrum: (DMSO d 6 ) 2.38 (s, 3H) ; 3.8 (s, 3H) ; 6.06 (d, IH) ; 7.39 (d, IH) ; 7.82 (d, IH) MS: 163.3 [M+H]+ A solution of boron tribromide (64 μl, 0.68 mmol) in methylene chloride (200 μl) was added to a solution of 5-methoxy-2-methyl-lH-pyrrolo[2,3-b]pyridine (50 mg, 0.308 mmol) in methylene chloride (4 ml) cooled at -30°C. The mixture was left to warm up to ambient temperature and further stiπed for 3 hours. The mixture was poured onto ice. The pH was adjusted to 6.2 with 6N aqueous sodium hydroxide followed by 2 N aqueous hydrogen chloride. The mixture was extracted with ethyl acetate. The organic layer was washed with water, followed by brine and dried (MgSO 4 ), filtered and the filtrate was evaporated. The residue was purified by column chromatography, eluting with with methylene chloride followed by methylene chloride/methanol (98/2 followed by 95/5). The fractions containing the expected product were combined and evaporated to give 2-methyl-l-H r ~pyrrolo[2,3- 6]pyridin-5-ol (45 mg, quantitative). 1H NMR Spectrum: (DMSO d 6 ) 2.4 (s, 3H) ; 5.96 (s, IH) ; 7.12 (d, IH) ; 7.69 (d, IH) ; 8.9 (s, IH) ; 11.07 (br s, IH) MS: 149.2 [M+H]+

Claims: CLAIMS 1. The use of a compound ofthe formula I: (I) wherein: ring C is a 9 or 10-membered bicychc heteroaromatic group containing at least one nitrogen atom in the ring attached to Z and optionally containing a further 1-3 heteroatoms, selected independently from O, S and N, with the proviso that ring C is not a quinazoline, quinoline or cinnoline group; either any one of G 1; G , G 3 , G 4 and G 5 is nitrogen and the other four are -CH-, or G l5 G 2 , G 3 , G 4 and G 5 are all -CH-; Z is -O-, -NH- or -S-; Z is linked to any one of G l5 G 2 , G 3 and G which is a free carbon atom; n is an integer from 0 to 5; any ofthe substituents R 1 may be attached at any free carbon atom ofthe indole, azaindole or indazole group, such free carbon atoms maybe G \ , G 2 , G 3 , G 4 or G 5 or may be at the 3-position ofthe indole, azaindole or indazole group; m is an integer from 0 to 2; R b represents hydrogen, Cι- 4 alkyl, d- 4 alkoxyCι- 4 alkyl, arninoC 1- alkyl, Cι- alkylaminoCι- alkyl, di(C_. 3 alkyl)aminoCι- 4 alkyl, d-salkenylaminod^alkyl, C 2 - 5 alkynylaminoC 1- alkyl, - C_- 5 alkyl(ring A) wherein ring A is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, moφholino and thiomoφholino and wherein ring A may bear one or more substituents selected from dialkyl, d-salkenyl, C 2 -salkynyl, hydroxy, oxo, halogeno, cyano, cyanoCι_ 4 alkyl, C_- 4 alkylsulphonyl and C_. 4 alkanoyl; R 1 represents hydrogen, oxo, hydroxy, halogeno, Cι- alkyl, Cι- 4 alkoxy, C_- 4 alkoxyC 1-4 alkyl, aminoCι- 4 alkyl, d-salkylaminoC.^alkyl, di(C 1 . 3 a_kyl)aminoCι. 4 a_kyl, -d-salky^ring B) wherein ring B is selected from azetidinyl, pyπolidinyl, piperidinyl, piperazinyl, N- methylpiperazinyl, N-ethylpiperazinyl, moφholino and thiomoφholino; R 2 represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, d- 3 alkyl, d- 3alkoxy, d^alkylsulphanyl, -NR 3 R 4 (wherein R 3 and R 4 , which may be the same or different, each represents hydrogen or C h alky!), or R 5 X 1 - (wherein X 1 represents a direct bond, -O-, - CH 2 -, -OC(O)-, -C(O)-, -S-, -SO-, -SO 2 -, -NR 6 C(O)-, -C(O)NR 7 -, -SO 2 NR 8 -, -NR 9 SO 2 - or - NR 10 - (wherein R 6 , R 7 , R 8 , R 9 and R 10 each independently represents hydrogen, Cι- 3 alkyl or C 1 - 3 alkoxyC 2 - 3 alkyl), and R 5 is selected from one ofthe following twenty-two groups: 1) hydrogen, oxiranylC_- 4 alkyl or d-salkyl which maybe unsubstituted or which maybe substituted with one or more groups selected from hydroxy, fluoro, chloro, bromo and amino; 2) Cι -5 alkylX 2 C(O)R π (wherein X 2 represents -O- or -NR 12 - (in which R 12 represents hydrogen, Cι- 3 alkyl or C 1 - 3 alkoxyC 2 - 3 alkyl) and R 11 represents C 1 . 3 alkyl, -NR 13 R 14 or -OR 15 (wherein R 13 , R 14 and R 15 which may be the same or different each represents hydrogen, d_ 5 alkyl or C 1 - 3 alkoxyC 2 - 3 alkyl)); 3) d- 5 alkylX 3 R 16 (wherein X 3 represents -O-, -S-, -SO-, -SO 2 -, -OC(O)-, -NR 17 C(O)-, - C(O)NR 18 -, -SO 2 NR 19 -, -NR 20 SO 2 - or -NR 21 - (wherein R 17 , R 18 , R 19 , R 20 and R 21 each independently represents hydrogen, C_. 3 alkyl or Cι- 3 alkoxyC 2 . 3 alkyl) and R 16 represents hydrogen, Cι- 3 alkyl, cyclopentyl, cyclohexyl or a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which d- 3 alkyl group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno and d- 4 alkoxy and which cyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, d_ 4 cyanoalkyl, d- 4 alkyl, d- 4 hydroxyalkyl, C 1-4 alkoxy, d- 4 alkoxyd. 4 alkyl, d- 4 alkylsulphonylC_- 4 alkyl, C 1- a_koxycarbonyl, C_- 4 aminoalkyl, C 1 . 4 alkylamino, di(Cι_ 4 alkyl)amino, alkoxy, di(Cι- 4 alkyl)aminod- 4 alkoxy and a group -(-O-) f (C 1 . 4 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C 1- alkyl)); 4) Cι- 5 alkyιX 4 C 1 - 5 alkylX 5 R 22 (wherein X 4 and X 5 which maybe the same or different are each -O-, -S-, -SO-, -SO 2 -, -NR 23 C(O)-, -C(O)NR 24 -, -SO 2 NR 25 -, -NR 26 SO 2 - or -NR 27 - (wherein R 23 , R 24 , R 25 , R 26 and R 27 each independently represents hydrogen, C 1-3 alkyl or C 1-3 alkoxyC 2 - 3 alkyl) and R 22 represents hydrogen, Cι -3 alkyl or C 1 . 3 alkoxyC 2 - 3 alkyl); 9S 9R 5) R (wherein R is a A-, 5- or 6-membered saturated heterocyclic group (linked via carbon 5 or nitrogen) with 1-2 heteroatoms, selected independently from O, S and N, which heterocyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1-4 cyanoalkyl, C 1- alkyl, Cι. 4 hydroxy alkyl, C 1-4 alkoxy, C 1-4 alkanoyl, Cι -4 alkoxyC 1-4 alkyl, Ci- alkylsulphonyl, C 1-4 alkylsulphonylC 1- alkyl, Cι- alkoxycarbonyl, C 1-4 aminoalkyl, d. 4 alkylamino, di(C 1-4 alkyl)amino, Cι- alkylaminoCι- 4 alkyl, di(C 1- alkyl)aminoCι- alkyl, Ci- 10 alkylaminoCι- alkoxy, di(C 1-4 alkyl)aminoC 1 . 4 alkoxy and a group -(-O-) f (C-|. alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from C 1-4 alkyl)); 6) d- 5 alkylR 28 (wherein R 28 is as defined herein); 15 7) C . 5 alkenylR 28 (wherein R 28 is as defined herein); 9R 9R 8) C 2 - 5 alkynylR (wherein R is as defined herein); 9) R 29 (wherein R 29 represents a pyridone group, a phenyl group or a 5 -6-membered aromatic heterocyclic group (linked via carbon or nitrogen) with 1-3 heteroatoms selected from O, N and S, which pyridone, phenyl or aromatic heterocyclic group may carry up to 5 substituents 20 selected from hydroxy, halogeno, amino, C 1- alkyl, C 1-4 alkoxy, C_. 4 hydroxyalkyl, d- 4 aminoalkyl, C 1 - 4 alkylamino, carboxy, trifluoromethyl, cyano, - C(O)NR 30 R 31 , -NR 32 C(O)R 33 (wherein R 30 , R 31 , R 32 and R 33 , which may be the same or different, each represents hydrogen, Cι- 4 alkyl or C 1-3 alkoxyC 2-3 alkyl) and a group -(-O-) f (Cι- alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a A-, 5- or 6-membered saturated 25 heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from d- 4 alkyl)); 10) C_- 5 alkylR 29 (wherein R 29 is as defined herein); 11) C 2 -5alkenylR 29 (wherein R 29 is as defined herein); 12) d-salkynylR 29 (wherein R 29 is as defined herein); 30 13) C_- 5 alkylX 6 R 29 (wherein X 6 represents -O-, -S-, -SO-, -SO 2 -, -NR 34 C(O)-, -C(O)NR 35 -, - SO 2 NR 36 -, -NR 37 SO 2 - or -NR 38 - (wherein R 34 , R 35 , R 36 , R 37 and R 38 each independently represents hydrogen, d- 3 alkyl or d- 3 alkoxyC . 3 alkyl) and R 29 is as defined herein); 14) C 2 - 5 alkenylX 7 R 29 (wherein X 7 represents -O-, -S-, -SO-, -SO 2 -, -NR 39 C(O)-, -C(O)NR 40 -, -SO 2 NR 41 -, -NR 42 SO 2 - or -NR 43 - (wherein R 39 , R 40 , R 41 , R 42 and R 43 each independently represents hydrogen, d. 3 alkyl or C 1-3 alkoxyC 2 - 3 alkyl) and R 29 is as defined herein); 5 15) C 2 . 5 a_kynylX 8 R 29 (wherein X 8 represents -O-, -S-, -SO-, -SO 2 -, -NR 44 C(O)-, -C(O)NR 45 -, -SO 2 NR 46 -, -NR 47 SO 2 - or -NR 48 - (wherein R 44 , R 45 , R 46 , R 47 and R 48 each independently represents hydrogen, Cι- 3 alkyl or C 1 - 3 alkoxyC 2 - 3 alkyl) and R 29 is as defined herein); 16) Ci- 4 alkylX 9 Ci -4 a_kylR 29 (wherein X 9 represents -O-, -S-, -SO-, -SO 2 -, -NR 49 C(O)-, - C(O)NR 50 -, -SO 2 NR 51 -, -NR 52 SO 2 - or -NR 53 - (wherein R 49 , R 50 , R 51 , R 52 and R 53 each 90 10 independently represents hydrogen, d_ 3 alkyl or Cι- alkoxyC 2 - 3 alkyl) and R is as defined herein); 17) d- 4 a_kylX 9 Cι- 4 alkylR 28 (wherein X 9 and R 28 are as defined herein); 18) C 2-5 alkenyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, Cι -4 alkylamino, N,N-di(C 1-4 alkyl)ammo, 15 aminosulphonyl, N-d- alkylaminosulphonyl and N,N-di(d. 4 alkyl)aminosulphonyl; 19) C 2 - 5 alkynyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro, amino, d. 4 alkylamino, N,N-di(C 1 . 4 alkyl)amino, aminosulphonyl, N-C_- alkylaminosulphonyl and N,N-di(C 1- a_kyl)aminosulphonyl; 20) C 2 - 5 alkenylX 9 C_ -4 alkylR 28 (wherein X 9 and R 28 are as defined herein); 20 21) C 2 - 5 alkynylX 9 d- 4 alkylR 28 (wherein X 9 and R 28 are as defined herein); and 22) C 1 - 4 aIkylR 54 (Cι -4 alkyl) q (X 9 ) r R 55 (wherein X 9 is as defined herein, q is 0 or 1, r is 0 or 1, and R 54 and R 55 are each independently selected from hydrogen, d- 3 alkyl, cyclopentyl, cyclohexyl and a A-, 5- or 6-membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which d- 3 alkyl group may bear 1 or 2 substituents 25 selected from oxo, hydroxy, halogeno and d- 4 alkoxy and which cyclic group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, C 1- cyanoalkyl, C 1- alkyl, Ci- 4 hydroxyalkyl, C 1- alkoxy, Cι- alkoxyC 1- alkyl, d- a_kylsulphonylCι. alkyl, Ci- alkoxycarbonyl, C_- aminoalkyl, C_- 4 alkylamino, di(C 1 - 4 alkyl)amino, d- alkylaminod- 4 alkyl, di(C 1- alkyl)aminoCι -4 alkyl, di(C_- 4 a_kyl)aminod- 4 alkoxy 30 and a group -(-O-) f (C 1-4 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a 4-, 5- or 6- membered saturated heterocyclic group with 1-2 heteroatoms, selected independently from O, S and N, which cyclic group may bear one or more substituents selected from with the proviso that R 54 cannot be hydrogen); and additionally wherein any C__ 5 alkyl, C 2 -salkenyl or C 2 - 5 alkynyl group in R 5 X 1 - may bear one or more substituents selected from hydroxy, halogeno and amino); with the proviso that when ring C is wherein Z is as defined herein, (but Z is not a part of ring C, it is shown for the puφoses of clarity), at least one R 2 does not have a value selected from hydrogen, halogeno, Cι- 4 alkyl, C_. alkoxy and NR c R d (wherein each of R c and R d independently represents hydrogen, Cι- alkyl or phenyl which phenyl may bear 1-3 substituents selected from halogeno, trifluoromethyl, C i -4 alkyl and C ι - alkoxy) ; or a salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans. 2. The use of a compound according to claim 1 wherein the optionally substituted indole moiety of formula II: (II) wherein R 1 , R b , Gi, G 2 , G 3 , G , G 5 and n are as defined in claim 1; is selected from the indole moieties: 4-fluoro-2-methylindol-5-yl, 2-methylindol-5-yl, 2-methylindol-6-yl, 2,3-dimethylindol-5-yl, l-methylindol-5-yl, l,2-dimethylindol-5-yl, 4-fluoroindol-5-yl, 6-fluoroindol-5-yl, indol-5-yl and 3-methylindol-5-yl. 3. A compound of the formula lb : (lb) wherein ring C, R b , R 1 , R 2 , m and n are as defined in claim 1 and Zb represents -O-, -NH- or -S-; with the proviso that if Zb is -NH- then: at least one R 2 is not selected from hydrogen, chloro, bromo, methyl, phenyl(hydroxymethyl), dimethylamino, methylsulphanyl, methylsulphinyl, methylsulphonyl and hydroxycyclohexylamino ; X 1 is not selected from -CH 2 -, a direct bond and -C(O)NR 7 -, wherein R 7 and X 1 are as defined in claim 1; and where R 2 is a group R 5 -X ! and X 1 is -NR 6 C(O)- or -NR 9 SO 2 -, R 5 does not contain an alkenyl or alkynyl moiety, wherein R 5 , R 6 , R 9 and X 1 are as defined in claim 1; and with the further proviso that when ring C is wherein Zb is as defined herein, (but Zb is not a part of ring C, it is shown for the puφoses of clarity), at least one R does not have a value selected from hydrogen, halogeno, Cι- 4 alkyl, d. alkoxy and NR c R (wherein each of R c and R d independently represents hydrogen, d- 4 alkyl or phenyl which phenyl may bear 1-3 substituents selected from halogeno, trifluoromethyl, C 1-4 alkyl and Cι- alkoxy); or a salt thereof. 4. A compound according to claim 3 wherein ring C is selected from one ofthe following seven moieties: wherein Z is Zb as defined in claim 3 but is not part of ring C. 5. A compound according to claim 3 or claim 4 wherein ring C is a thienopyrimidine ring or a phthalazine ring. 6. A compound according to any one of claims 3 to 5 wherein Zb is -O- or -NH-. 7. A compound according to any one of claims 3 to 6 wherein R is hydrogen. 8. A compound according to any one of claims 3 to 7 wherein R 1 represents methyl, ethyl, trifluoromethyl or halogeno. 9. A compound according to any one of claims 3 to 8 wherein R 2 represents hydroxy, halogeno, nitro, trifluoromethyl, Cι -3 alkyl, cyano, amino or R 5 X ! - [wherein X 1 is as defined in claim 1 and R 5 is selected from one ofthe following twenty groups: 1) d- 3 alkyl which may be unsubstituted or which may be substituted with one or more groups selected from fluoro, chloro and bromo, or C 2 - 3 alkyl which may be unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) 2-(3,3-dimethylureido)ethyl, 3-(3,3-dimethylureido)propyl, 2-(3-methylureido)ethyl, 3-(3- methylureido)propyl, 2-ureidoethyl, 3-ureidopropyl, 2-(N,N-dimethylcarbamoyloxy)ethyl, 3- (N,N-dimethylcarbamoyloxy)propyl, 2-(N-methylcarbamoyloxy)ethyl, 3 -(N- methylcarbamoyloxy)propyl, 2-(carbamoyloxy)ethyl, 3-(carbamoyloxy)propyl, or 2-(N- methyl-N-(butoxycarbonyl)amino)ethyl; 3) C 2 - 3 alkylX 3 R 16 (wherein X 3 is as defined in claim 1 and R 16 is a group selected from d- 3 alkyl, cyclopentyl, cyclohexyl, pyπolidinyl, piperidinyl, piperazinyl, azetidinyl, imidazolidinyl and tetrahydropyranyl which group is linked to X 3 through a carbon atom and which Ci- 3 alkyl group may bear 1 or 2 substituents selected from hydroxy, halogeno and d- alkoxy and which cyclopentyl, cyclohexyl, pyπolidinyl, piperidinyl, piperazinyl, azetidinyl, imidazolidinyl or tetrahydropyranyl group may bear one substituent selected from oxo, hydroxy, halogeno, cyano, Cι -2 alkyl, C 1 - 2 hydroxyalkyl, d_ 2 alkoxy, d. alkoxyC 1-3 alkyl, d- 2 alkylsulphonyld- 3 a_kyl, d- 2 alkoxycarbonyl, d- 3 a_kylamino, di(Cι- 3 alkyl)amino, d- 3 alkylaminod- 3 alkyl, di(Cι. 3 alkyl)aminod- 3 alkyl, Ci- 3 alkylaminoC- . . 3 alkoxy, di d-salky aminod-salkoxy and a group -(-O-)f(C 1 - 3 alkyl) g ringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyπolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino)); 4) C 2 - 3 alkylX 4 C 2 - 3 alkylX 5 R 22 (wherein X 4 and X 5 are as defined in claim 1 and R 22 represents hydrogen or Cι- 2 alkyl); 5) R 28 (wherein R 28 is as defined in claim 1); 6) C 1-3 alkylR 59 (wherein R 59 is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, azetidinyl, imidazolidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and 1,3- dithian-2-yl, which group is linked to C 1-3 alkyl through a carbon atom and which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, d- 2 cyanoalkyl, Ci- 2 alkyl, Ci- 2 hydroxyalkyl, C 1-2 alkoxy, C 1-2 alkanoyl, d- 2 alkoxyd- 3 alkyl, C 1-2 alkylsulphonyl, C 1-2 alkylsulphonylC 1 - 3 alkyl, d-2alkoxycarbonyl, Cι- 3 alkylamino, di(C 1 - 3 alkyl)amino, d- 3 alkylaminoCι- 3 alkyl, di(C 1 - 3 alkyl)aminoC 1 - 3 alkyl, d-salkylaminoCi-salkoxy, di(C_. 3 alkyl)aminoC_- 3 alkoxy and a group -(-O-) f (C 1-3 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino)) or -salkylR 60 (wherein R 60 is a group selected from moφholino, thiomoφholino, azetidin-1-yl, pyrrohdin- 1-yl, piperazin-1-yl and piperidino which group may bear 1 or 2 substituents selected from oxo, hydroxy, halogeno, cyano, d- 2 cyanoalkyl, d- 2 alkyl, Cι -2 hydroxy alkyl, d-2alkoxy, Cι- 2 alkanoyl, C^alkoxyd. 3 alkyl, C 1 . 2 alkylsulphonyl, C 1-2 alkylsulphonylC 1-3 alkyl, C 1-2 alkoxycarbonyl, Cι- 3 alkylamino, di(Cι- 3 alkyl)amino, Cι- 3 alkylaminoCi- 3 alkyl, di(Cι -3 alkyl)aminoC 1 - 3 alkyl, Cι- 3 alkylaminod- 3 alkoxy, di(Cι- 3 alkyl)aminoCι- 3 alkoxy and a group -(-O-) f (C 1 - 3 alkyl)gringD (wherein f is 0 or 1, g is 0 or 1 and ring D is a heterocyclic group selected from pyrrolidinyl, methylpiperazinyl, piperidinyl, azetidinyl, moφholino and thiomoφholino)); 7) R 29 (wherein R 29 is as defined in claim 1); 8) d- alkylR 29 (wherein R 29 is as defined in claim 1); 9) l-R 29 but-2-en-4-yl (wherein R 29 is as defined in claim 1); 10) l-R 29 but-2-yn-4-yl (wherein R 29 is as defined in claim 1); 11) C_- 3 alkylX 6 R 29 (wherein X 6 and R 29 are as defined in claim 1); 12) l-(R 29 X 7 )but-2-en-4-yl (wherein X 7 and R 29 are as defined in claim 1); 13) l-(R 29 X 8 )but-2-yn-4-yl (wherein X 8 and R 29 are as defined in claim 1); 14) C2- 3 alkylX 9 Cι -3 alkylR 29 (wherein X 9 and R 29 are as defined in claim 1); 15) C 2 - 3 alkylX 9 Cι. 3 alkylR 28 (wherein X 9 and R 28 are as defined in claim 1); 16) C 2 . 5 alkenyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, C \ . 4 alkylamino, N,N-di(C 1- alkyl)amino, aminosulphonyl, N-Cι- alkylaminosulphonyl and N,N- di(C 1- alkyl)aminosulphonyl; 17) C 2 . 5 alkynyl which may be unsubstituted or which may be substituted with one or more fluorine atoms or with one or two groups selected from hydroxy, fluoro, amino, d- alkylamino, N,N-di(C_. 4 a_kyl)arnino, aminosulphonyl, N-C 1-4 alkylaminosulphonyl and N,N- di(C 1 - 4 alkyl)aminosulphonyl; 18) C 2 . 3 alkenylX 9 C 1-3 alkylR 28 (wherein X 9 and R 28 are as defined in claim 1); 19) C 2-3 alkynylX 9 C 1-3 alkylR 28 (wherein X 9 and R 28 are as defined in claim 1); and 20) C 1 _ 3 alkylR 54 (C 1 - 3 alkyl) q (X 9 ) r R 55 (wherein X 9 , q, r, R 54 and R 55 are as defined in claim 1); and additionally wherein any Ci-salkyl, C 2 -salkenyl or d-salkynyl group in R^ 1 - may bear one or more substituents selected from hydroxy, halogeno and amino]. 10. A compound selected from: l-(4-fluoroindol-5-yloxy)-4-(4-pyridylmethyl)phthalazine, 1 -(indol-6-yloxy)-4-(4-pyridylmethyl)phthalazine, l-(2-methylindol-6-yloxy)-4-(4-pyridylmethyl)phthalazine, 4-(4-fluoro-2-methylindol-5-yloxy)thieno[3,2-d]pyrimidine and l-(4-fluoro-2-methylindol-5-yloxy)-4-(4-pyridyhnethyl)phthalazine, or a salt thereof. 11. A compound according to any one of claims 3 to 10 in the form of a pharmaceutically acceptable salt. 12. A process for the preparation of a compound of formula lb or a salt thereof which comprises: (a) the reaction of a compound of the formula III: (III) (wherein ring C, R 2 and m are as defined in claim 1 and L 1 is a displaceable moiety), with a compound of the formula IV: (IV) (wherein R , R and n are as defined in claim 1, G \ , G 2 , G 3 , G and G 5 are all -CH- and Zb is as defined in claim 3); (b) a compound of formula lb or a salt thereof wherein at least one R 2 is R 5 X J wherein R 5 is as defined in claim 1 and X 1 is -O-, -S-, -OC(O)- or -NR 10 - (wherein R 10 independently represents hydrogen, d- 3 alkyl or C 1 - 3 alkoxyC2- 3 alkyl) may be prepared by the reaction of a compound ofthe formula V: (V) (wherein ring C, R , R 1 , R 2 and n are as defined in claim 1, G \ , G 2 , G 3 , G 4 and G 5 are all -CH- Zb is as defined in claim 3, X 1 is as herein defined in this section and s is 0 or 1) with a compound of formula VI: R 5 - (VI) (wherein R 5 is as defined in claim 1 and L 1 is as defined herein); (c) a compound of formula lb or a salt thereof wherein at least one R 2 is R 5 X ! wherein R 5 is as defined in claim 1 and X 1 is -O-, -S-, -OC(O)- or -NR 10 - (wherein R 10 represents hydrogen, d -3 alkyl or Cι- 3 alkoxyC2- 3 alkyl) may be prepared by the reaction of a compound of the formula VII: (VII) with a compound ofthe formula VIII: R 5 -X 1 -H (VIII) (wherein ring C, R b , R 1 , R 2 , R 5 and n are all as defined in claim 1, G \ , G 2 , G 3 , G 4 and G 5 are all -CH-, Zb is as defined in claim 3, L 1 and s are as defined herein and X 1 is as herein defined in this section); (d) a compound of formula lb or a salt thereof wherein at least one R 2 is R 5 X ] wherein X 1 is as defined in claim 1 and R 5 is d-salkylR 62 , wherein R 62 is selected from one ofthe following nine groups: 1) X 10 C 1-3 alkyl (wherein X 10 represents -O-, -S-, -SO 2 -, -NR 63 C(O)- or -NR 64 SO 2 - (wherein R 63 and R 64 which may be the same or different are each hydrogen, d- 3 alkyl or C μ 3 alkoxy C 2 . 3 alkyl); 2) NR R (wherein R and R which may be the same or different are each hydrogen, Ci- 3 alkyl or C_. 3 alkoxyC -3 alkyl); 3) X 11 Cι. 5 alkylX 5 R 22 (wherein X 11 represents -O-, -S-, -SO 2 -, -NR 67 C(O)-, -NR 68 SO 2 - or- NR 69 - (wherein R 67 , R 68 , and R 69 which maybe the same or different are each hydrogen, Cι_ 3 alkyl or Cι- 3 alkoxyC 2 - 3 alkyl) and X 5 and R 22 are as defined in claim 1); 4) R 28 (wherein R 28 is as defined in claim 1); 5) X 12 R 29 (wherein X 12 represents -O-, -S-, -SO 2 -, -NR 70 C(O)-, -NR 71 SO 2 -, or-NR 72 - (wherein R , R , and R which may be the same or different are each hydrogen, Cι- 3 alkyl or 9Q Cι- 3 alkoxyC - 3 alkyl) and R is as defined m claim 1); and 6) X 13 Cι- 3 alkylR 29 (wherein X 13 represents -O-, -S-, -SO 2 -, -NR 73 C(O)-, -NR 74 SO 2 - or -NR 75 - (wherein R 73 , R 74 and R 75 each independently represents hydrogen, C 1-3 alkyl or Cι -3 alkoxyC 2 - 3 alkyl) and R 29 is as defined in claim 1); 7) R 29 (wherein R 29 is as defined in claim 1); 8) X 13 Cι_ 4 alkylR 28 (wherein X 13 and R 28 are as defined in claim 1); and 9) R 54 (Cι -4 alkyl) q (X 9 ) r R 55 (wherein q, r, X 9 , R 54 and R 55 are as defined in claim 1); may be prepared by reacting a compound ofthe formula IX: (IX) (wherein ring C, X 1 , R , R 1 , R 2 and n are as defined in claim 1, G . , G 2 , G 3 , G and G 5 are all - CH-, Zb is as defined in claim 3 and L 1 , and s are as defined herein) with a compound ofthe formula X: R 62 -H (X) (wherein R 62 is as defined herein); (e) a compound ofthe formula lb or a salt thereof wherein one or more ofthe substituents (R 2 ) m is represented by -NR 76 R 77 , where one (and the other is hydrogen) or both of R 76 and R 77 are Cι- 3 alkyl, may be effected by the reaction of compounds of formula I wherein the substituent (R 2 ) m is an amino group and an alkylating agent; (f) a compound ofthe formula lb or a salt thereof wherein X 1 is -SO- or -SO 2 - may be prepared by oxidation from the coπesponding compound in which X 1 is -S- or -SO- (when X 1 is -SO 2 - is required in the final product); and when a salt of a compound of formula lb is required, reaction ofthe compound obtained with an acid or base whereby to obtain the desired salt. 13. A pharmaceutical composition which comprises a compound of the formula lb as defined in claim 3 or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable excipient or carrier. 14. A method for producing an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal in need of such treatment which comprises administering to said animal an effective amount of a compound of formula I as defined in claim 1 or a pharmaceutically acceptable salt thereof.

Inventors: HENNEQUIN LAURENT FRANCOIS AND, HENNEQUIN, LAURENT, FRANCOIS, ANDRE
Applicants: ASTRAZENECA AB, ASTRAZENECA UK LTD, HENNEQUIN LAURENT FRANCOIS AND, ASTRAZENECA UK LIMITED, HENNEQUIN, LAURENT, FRANCOIS, ANDRE
Application year: 2001
Main classification: C07D401
IPC codes: A61K31, A61P3, A61P9, A61P15, A61P17, A61P27, A61P29, A61P35, A61P43, C07D401, C07D495