CRYSTAL STRUCTURE

Abstract: Structural coordinates obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an arginine deliminase (DI) or a fragment thereof to X-ray diffraction measurements and deducing the structural coordinates from the diffraction measurements are used to identify, screen, characterise, design or modify a chemical entity. The chemical entities so generated may be used in methods of therapy or to identify the presence or absence of a DDAH or DI substrate.

Description: CRYSTAL STRUCTURE Field of the invention The invention relates to a crystal of an enzyme and a method for making that crystal. The structural coordinates of the crystal may be used to identify or design chemical entities which are modified enzymes or which bind to the enzyme. Background to the invention N G -Mefhylated derivatives of arginine wilnin a wide range of eukaryotic proteins have been known for many years, although their function remains ill- defined. Methylation of arginine in proteins is carried out by enzymes of the protein- arginine methyl transferase (PRMT) family. Proteolysis of methyl-arginine- containing proteins releases free methylarginine derivatives into the cytoplasm. Levels of methylarginines vary greatly between different tissues and elevated levels are found in a variety of pathological conditions and clinical disorders. Catabolism of two the asymmetrically methylated arginine derivatives N G N G -dimethyl-L- arginine (ADMA), and N G -monomethyl-L-arginine (L-NMMA), to citrulline and mono- or di-methylamine is carried out by dimemylargirirϊe dimethylaminohydrolase (DDAH, EC 3.5.3.18), which does not, however, hydrolyse symmetrical N N σ - dimethyl-L-arginine (SDMA). ADMA and L-NMMA (but not SDMA) are reversible inhibitors of all three isoforms of nitric oxide synthase (NOS) and may act as endogenous regulators of NOS in vivo. Thus DDAH, which controls levels of asymmetrically methylated arginine derivatives, may have therapeutic potential through its ability to indirectly influence the activity of NOS ' . Two human DDAH isoforms have been identified - DDAH I and DDAH II and this is the cas'e with some other mammals. Both enzymes have restricted tissue distributions which closely match either neuronal NOS or endothelial NOS respectively, suggesting an isoform-specific mechanism for regulating NOS activity via methylarginine. More recently microbial DDAH enzymes have been identified (Santa Maria et al., 1999) and so far each species has only one isoform. Their functional role is likely to be different from that in mammals, since bacteria lack NOS. Sequence comparisons have suggested a similarity between human DDAH and arginine deiminase (DI, EC 3.5.3.6), a microbial enzyme that converts arginine to citrulline arid ammonia. 5 Summary of the invention We have determined the crystal structure of a bacterial DDAH from Pseudomonas auruginosa (PaDDAH ). According to the present invention there is thus provided use of the structural 0 coordinates obtainable by subjecting by subjecting a crystal comprising a dimethylargiriine dimethylaminohydrolase (DDAH) or a fragment thereof or an arginine deiminase (DI) or a fragment thereof to X-ray diffraction measurements and deducing the structural coordinates from the diffraction measurements, to identify, screen, characterise, design or modify a chemical entity. 5 The invention also provides: a chemical entity generated by a use according to the invention; a method for identifying, screening, characterising or designing a chemical entity which is a modified DDAH or DI or binds to a DDAH or DI, which , . method comprises comparing a structural model of the DDAH or DI with a 0 structural model for said chemical entity, and thereby determining whether said chemical entity is likely to be a modified DDAH or DI or bind to the DDAH or DI, wherein said structural model of the DDAH is derived from structural coordinates determined by subjecting to X-Ray diffraction measurements a crystal comprising a DDAH or DI or a fragment thereof; 5 - a chemical entity identified by a method of the invention; a method for treatirig a host suffering from a condition in which abnormal nitric oxide metabolism is implicated or a bacterial infection, which method comprises administering to the host a therapeutically effective amount of a chemical entity of the invention; 0 a method for identifying the presence or absence of an asymmetrically methylated arginine derivative in a sample, which method comprises: X (a) contacting the sample with a modified DDAH of the invention; and (b) deteπnining whether the modified DDAH binds to an asymmetrically methylated arginine derivative; a crystal comprising a DDAH or a fragment thereof or a DI or a fragment thereof; a method for preparing a crystal, which method comprises forming a crystal of a substance comprising a DDAH or a DI; a DDAH or DI which is an inactive mutant; and a machine readable data storage medium comprising a data storage material encoded with machine readable data which when read by an appropriate machine is capable of displaying a three dimensional representation of a crystal of the invention. Brief description of the figures Figure 1 shows the overall fold of DDAH; every tenth residue is numbered. Figure 2 shows a worm representation of the backbone of DDAH with the catalytic residues indicated: Ser, (S, mutant from Cys); His (H) ; Glu (E) and the citrulline inhibitor (C). Detailed description of the invention We have successfully crystallised a bacterial DDAH from Pseudomonas auruginosa (PaDDAH ). This is the first crystallisation of a DDAH. This has allowed us to determine the crystal structure of PaDDAH, revealing that it belongs to a structural superfamily of arginine-modifying enzymes which includes arginine:glycine amidinotransferase (AT, EC 2.1.4.1) and arginine deiminase (DI, EC 3.5.3.6). The three-dimensional structure of PaDDAH is set out in Figure 1. We have further identified Glul 14, His 162 and Cys249 as residues that are implicated in the active site. Site-directed mutagenesis of each of these residues produced enzymes that were inactive. A Cys:ser (C249S) mutant was used in the determination of crystal structures of a DDAH: substrate (ADMA) complex and a DDAH:product (citrulline) complex (Figure 2). This allowed identification of ligand-binding residues around the active site. Our crystallisation studies have allowed us to solve the structural coordinates of a DDAH enzyme. The invention provides use of the structure coordinates of an arginine modifying enzyme to identify, characterise, design or screen chemical entities. In particular, the chemical entities of interest are modified arginine- modifying enzymes or chemical entities which bind to an argirrine-modifying enzyme. Particular arginine-modifying enzymes of interest are DDAHs and DIs. Previously, it has not been possible to crystallise a DDAH or a DI. For example, attempts to crystallise mammalian DDAHs have not been successful and over-expression of DI in bacterial cells lead to cell death. We have now identified residues that when mutated result in an inactive PaDDAH. Those residues are conserved between PaDDAH and DI. It is therefore now possible to produce inactive DI and therefore to successfully over-express that enzyme. Thus, in the light of our results, crystallisation ofDI is now possible for the first time. In addition, the similarities between bacterial and mammalian. DDAHs allow the use of our bacterial data in the design of chemical entities for use in mammalian contexts. The chemical entities of the invention have uses in for example, therapy, diagnosis, quantification of DDAH or DI substrate concentrations and other investigative applications. Typically, the structure coordinates used are obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an argiriine deiminase (DI) to X-ray diffraction measurements and deducing the structural coordinates from the diffraction measurements, to identify, screen, characterise, design or modify a chemical entity. The structural coordinates indicate the positions of individual atoms witriin the crystal give an indication of the available space for adjusting the position of individual atoms when designing a chemical entity. The structure coordinates for native PaDDAH are shown in Table II and those for C249S + citrulline are shown in Table III. Those structure coordinates are suitable for use according to the invention. In addition, structural coordinates obtainable by solving the data statistics in Table I may be used. The crystal subjected to X-ray diffraction methods comprises a DDAH or a fragment thereof or a DI or a fragment thereof. The DDAH or DI may be from any source. Thus, the DDAH or DI may be a bacterial DDAH, for example one which originates from Pseudomonas aeruginosa, Strepyomyces coelicolor or Mycobacterium tuberculosis. Examples of bacterial arginine-modifying enzyme sequences are set out in Santa Maria et al, 1999, Mol. Microbiol. 33, 1278-1279. Alternatively, a DDAH may be derived from a mammal, in which case the DDAH may be a DDAHI, for example human DDAHI or a DDAHII, for example human DDAHII. Suitable human DDAH sequences are set out in Leiper et al, 1999, Biochem. J. 343, 209-214. A fragment of a DDAH or DI may also be used. Typically, a suitable fragment will be up to 10 amino acids in length, up to 20 amino acids in length, up to 50 amino acids in length, up to 100 amino acids in length, up to 200 amino acids in length, up to 300 amino acids in length, up to 400 amino acids in length, up to 500 amino acids in length or up to the entire length of the DDAH or DI polypeptide. A preferred fragment is one which comprises all the amino acids required to form an active site of the DDAH or DI under study. Other preferred fragments are those which form antigenic epitopes of the DDAH or DI in question. The DDAH may be a modified form of an entire DDAH or DI or a modified form of a fragment thereof. For example, the DDAH or DI may be modified by insertion, deletion, N-terminal or C-terminal addition, or substitution of an amino acid by another amino acid. Those types of modifications may be combined to produce a modified DDAH or DI for use in the mvention. Amino acid substitutions may be conservative substitutions. From 1,2, 3, 5 or 10 to 20, 30 or 50 modifications may be made in comparison to the corresponding wild-type DDAH or DI sequence. Thus, a DDAH or DI for use in the invention may be a mutant sequence. That is, it may have a polypeptide sequence which is different from that of the corresponding wild-type sequence. Typically, when crystallised, a DDAH or DI mutant or fragment thereof, will adopt a similar three-dimensional structure to that adopted by the corresponding DDAH or DI or a fragment thereof. A mutant may be an inactive DDAH or DI. An inactive DDAH or DI is one which shows less than 20% of the enzyme activity shown by the corresponding wild- type enzyme, when the mutant and wild-type are compared using the colorimetric assay described in Leiper et α .,1999 (supra). Preferred, inactive enzymes are those which show less than 10% of the enzyme activity shown by the corresponding wild- type enzyme or preferably substantially no enzyme activity. Preferred inactive DDAHs or DIs are those which carry a mutation at an amino acid equivalent to El 14, HI 62 or C249 of PaDDAH. Those residues are directly involved in the reaction catalysed by PaDDAH. An equivalent amino acid is an amino acid in a DDAH derived from a species other Pseudomonas aeruginosa or a DI which occurs at an similar/corresponding position to a particular amino acid in the P. aeruginosa sequence and fulfils approximately the same function as the amino acid it is equivalent to, for example it takes part in catalysis. Examples of equivalent amino acids for a variety of arginine-modifying enzymes are set out in Table IV. For example, when compared to PaDDAH, human DDAH shows conservation of the ^active site residues except that, in common with most species looked at, the catalytic Glu of PaDDAH is Asp in the human sequence. An equivalent amino acid will be readily identifiable by those skilled in the art, for example by carrying out sequence alignments. Computer programs for carrying out sequence alignments are will known to those skilled in the art and include, for example BLAST and PSI-BLAST as described in Altschul et al. (1997) Nucleic Acids Res. 25, 3389-3402. A DDAH or DI for use in the invention may be chemically modified. Thus, particular amino acids can be labelled with a heavy metal, for example met onine residues may be labelled with selenium. A DDAH of DI for use in the invention may also be post-translationally modified. For example it may be glycosylated or comprise modified amino acid residues. A DDAH of DI can be in a variety of forms of polypeptide derivatives, including amides and conjugates with polypeptides. Chemically modified DDAHs or DIs also include those having one or more residues chemically derivatized by reaction of a functional side group. Such derivatized side groups mclude those which have been derivatized to form amine hydrochlorides, p-toluene sulfonyl groups, carbobenzoxy groups, t-butyloxycarbonyl groups, chloroacetyl groups and forrnyl groups. Free carboxyl groups may be derivatized to form salts, methyl and ethyl esters or other types of esters or hydrazides. Free hydroxyl groups may be derivatized to form O-acyl or O-alkyl derivatives. The -i idazole nitrogen of histidine may be derivatized to form N-im- benzylhistidine. A DDAH or DI may be isolated by any suitable means for use in crystallization studies. For example, a DDAH or a DI may be purified using biochemical means from a suitable source. Typically, however, it will be convenient to over-express a DDAH or a DI in cells and purify the DDAH or DI from those cells. Thus, a polynucleotide encoding a DDAH or a DI as described herein may be used in the construction of a vector. It may be necessary to use a polynucleotide encoding an inactive DDAH or DI as defined above. This may be necessary if over-expression of an active DDAH or DI disrupts cell function to the extent that expression cannot occur to a desired level. Preferably, a polynucleotide in a vector is operably linked to a control sequence which is capable of providing for the expression of the coding sequence by a host cell when the construct in transferred into that cell, i.e. the vector is an expression vector. The term "operably linked" refers to a juxtaposition wherein the components described are in a relationship permitting them to function in their intended manner. A regulatory sequence, such as a promoter, "operably linked" to a coding sequence is positioned in such a way that expression of the coding sequence is achieved under conditions compatible with the regulatory sequence. The vectors may be for example, plasmid, virus or phage vectors provided with a origin of replication, optionally a promoter for the expression of the said polynucleotide and optionally a regulator of the promoter. The vectors may contain one or more selectable marker genes, for example an ampiciUin resistence gene in the case of a bacterial plasmid or a resistance gene for a fungal vector. Vectors may be used to transfect or transform a host cell, for example, a bacterial, yeast, insect or mammalian host cell. Promoters and other expression regulation signals may be selected to be compatible with the host cell for which expression is designed. For example, yeast promoters include S. cerevisiae GAL4 and ADH promoters, S. pombe nmtl and adh promoter. Mammalian include promoters such as β-actin promoters or the metallothionein promoter which can be induced in response to heavy metals such as cadmium. Viral promoters such as the S V40 large T antigen promoter or adenovirus promoters may also be used. All these promoters are readily available in the art. The vector may further include sequences flanking the polynucleotide giving rise to polynucleotides which help in the expression of the DDAH or DI. Constructs which contain a polynucleotide encoding a DDAH or a DI may be transferred, for example by transformation or transfection, into a cell so that the cells express the DDAH or DI. Such cells may express the DDAH or DI transiently or stably. Suitable cells may be higher eukaryotic cell lines, such as mammalian cells or insect cells, lower eukaryotic cells, such as yeast or prokaryotic cells such as bacterial cells. The cell line may be selected so that appropriate post-translational modification occurs. It is also possible for the proteins of the invention to be transiently expressed in a cell line or on a membrane, such as " for example in a baculovirus expression system. Such systems, which are adapted to express the proteins according to the invention, are also included within the scope of the present invention. The DDAH or DI may be crystallised according to any method known to those skilled in the art. X-ray diffraction may be carried out accordmg to any method known to those skilled in the art. The data collected from X-ray diffraction experiments may be processed to deduce the structural coordinates of the DDAH or DI being studied using methods we ' ll known to those skilled in the art. The invention also provides the use of the structural coordinates obtainable by subjecting a crystal comprising a DDAH or a fragment thereof or a DI or a fragment thereof bound to a substrate or product to X-ray diffraction measurements and deducing the structural coordinates from the diffraction measurements. Suitable substrates are asymmetric methylated arginine derivatives, for example N N G - dimethyl-L-arginine (ADMA) or N G -monomefhyl-L-arginine (L-NMMA) in the case of DDAH and arginine in the case of DI. A suitable product is citrulline for DDAH orDI. When a crystals comprising an arginine-modifying enzyme bound to a substrate or product is used, typically an inactive form of a DDAH or DI is used. The DDAH or DI is inactive in the sense that it is binds a substrate but substantially cannot metabolize that substrate. An alternative suitable inactive DDAH or DI can typically be capable of binding the product without metabolizing that product. A suitable inactive DDAH or DI may be capable of binding both substrate and product. The invention provides the use of structural coordinates to identify, characterise, design or screen a chemical entity. The chemical entity may be for example a modified DDAH or DI or a chemical entity which binds to a DDAH or a DI. A chemical entity which binds to a DDAH or a DI may be, for example, an inhibitor or an activator of that DDAH or DI. A modified DDAH or DI may have a different sequence to its corresponding DDAH or DI. Alternatively, it may have the same sequence as its corresponding wild-type sequence, but comprise one or more chemically modified amino acids. Preferred modifications are those which alter the activity characteristics of the DDAH or DI, but which do not substantially alter the shape of the DDAH or DI. A chemical entity which binds to a DDAH or a DI is any chemical entity capable of forming an association with the DDAH or DI. The chemical entity may bind to a DDAH or DI non-specifically, in which case it will bind to other partners, or may bind specifically to a DDAH or a DI. Chemical entities which bind DDAH or DI may be small molecules, for example small organic or inorganic molecules. Alternatively, the chemical entity could be a large/macromolecule, for example a polypeptide or peptide. The polypeptide or peptide may be for example, an antibody or a fragment of an antibody. An inhibitor of a DDAH or a DI is one which, when present, produces a measurable reduction in DDAH or DI activity in the colorimetric assay described in Leiper etal., 1999 (supra). An activator of a DDAH or DI is one which, when present, produces a measurable increase in DDAH or DI activity in the colorimetric assay described in Leiper et al., 1999 (supra). Preferred inhibitors are those which reduces DDAH or DI activity by at least 10%, at least 20%, at least 30%, at least 40% at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95% or at least 99% at a concentration of the inhibitor of lμg ml "1 , lOμg ml *1 , lOOμg ml "1 , 500μg ml "1 , l g ml 4 ' lOmg ml *1 , lOOmg ml *1 . Preferred activators are those which increase DDAH or DI activity by at least 10%, at least 25%, at least 50%, at least 100%, at least, 200%, at least 500% or at least 1000% at a concentration of the activator lμg ml "1 , lOμg ml "1 , lOOμg ml "1 , 500μg ml "1 , lmg ml "1, lOmg ml "1 , lOOmg ml *1 . The percentage inhibition or activation represents the percentage decrease or increase in activity in a comparison of assays in the presence and absence of the test substance. Any combination of the above mentioned degrees of percentage inhibition or activation and concentration of inhibitor or activator may be used to define an inhibitor or activator of the invention, with greater inhibition or activation ' at lower concentrations being preferred. Inhibition may occur if, for example, the inhibitor resembles the substrate and binds at the active site of the DDAH or DI. The substrate is thus prevented from binding to the same active site and the rate of catalysis is reduced by reducing the proportion of enzyme molecules bound to substrate (competitive inhibition): An inhibitor may also exert its effects by non-competitive inhibition where the inhibitor and substrate can bind simultaneously to the DDAH or DI and thus bind at different • non-overlapping sites. Inhibition occurs as the turnover number of the DDAH of DI decreases. Activation may occur, for example, if the modulator increases the affinity of the substrate for the DDAH or DI or vice versa. This means that the proportion of DDAH or DI molecules bound to a substrate is increased and the rate of catalysis will thus increase. The structural coordinates of a DDAH of a DI crystal, in particular a crystal of a DDAH of a DI bound to its substrate, may allow the skilled person to predict which amino acids may be important in active site formation and. which amino acids are important in contacting the substrate and product. The substrate binding site bound to the DDAH or DI peptide to be shown as a two dimensional representation, for example as a LIGPLOT or a three dimensional representation by physical models or as displayed on a computer screen. Such representations can be used to design modifications of a DDAH or DI, for example in the design of a DDAH or DI with altered activity characteristics, to design chemical entities which bind a DDAH or a DI or to design modifications to chemical entities which bind a DDAH or a DI. Example of modifications include modification to increase the avidity of a DDAH or a DI for its substrate or product. That type of modification may increase the activity of a DDAH or a DI, increase the avidity of an inactive DDAH or DI for a DDAH or DI substrate or may alter the substrate specificity of the DDAH or DI in question. Alternatively, modifications may increase the avidity with which a chemical entity binds DDAH or DI. Thus modifications may be made to a known inhibitor or activator of DDAH or DI so that they bind DDAH or DI with increased affinity, thus increasing their efficacy. The avidity of a DDAH or DI for its substrate or product or of a chemical entity for a DDAH of DI may be increased by modifying the active siteto increase the amount and number of interactions favourable to binding. Favourable interactions may be increased by extending the structure of the substrate or product binding site or the chemical entity into spaces which are shown in the two dimensional or three dimensional representations to be unoccupied or filled with water molecules. The representations of the structures may be used in other ways to modify the structure of a DDAH or DI. The representations of a DDAH or DI active site may be used to model constraints by the putative introduction of covalent bonds between the atoms which come, close together when a DDAH or DI binds to a substrate or product; one or more chemical linkers may be used between atoms of a DDAH or DI to constrain the active site to the required conformation, and/or one or more amino acids of a DDAH or DI may be replaced by analogues of the natural amino acids which help to constrain the conformation of the active site. On the basis " of such modelling, modified DDAHs or DIs may be identified, characterised, designed or screened. Representation of the active site bound to a substrate may be used to predict which residues of a DDAH or DI are likely to be involved in the steric hindrance. Such residues may be modified, replaced or deleted to decrease the steric hindrance in order to increase avidity. In general it will be necessary to process the structural coordinates obtainable according to the invention in computer-based methods in order to identify or design chemical identities with a desired molecular structure or to identify chemical entities whose structure is similar to all or a part of another chemical entity of interest. Thus, chemical entities which have a structure similar to a DDAH or a fragment thereof or a DI or a fragment thereof may be identified or designed. Also, chemical entities which bind to a DDAH or a DI may be identified or designed. Preferably, that type of chemical entity will bind at the active site of a DDAH or DI. Such computer-based methods fall into two-broad classes: database methods and de novo design methods. In database methods the chemical entity of interest is compared to all chemical entities present in a database of chemical structures and chemical identities whose " structure is in some way similar to the compound of interest are identified. The structures in the database are based either on experimental data, generated by NMR or x-ray crystallography, or modeled three- dimensional structures based on two-dimensional data. In de novo design methods, models of chemical entities whose structure is in some way similar to the compound of interest are generated by a computer program using information derived from known structures and/or theoretical rules. Using the structural coordinates, a three dimensional representation of the surface of a DDAH or a DI, in particular the active site, can be produced using Catalyst Software such as Catalyst/SHAPE, Catalyst/COMPARE, DBServer HipHop Ludi, MCSS and Hook which are available from Molecular Simulations Ltd., 240/250 The Quorum, Barnwell Road, Cambridge, England. Modified DDAHs or DIs, for example can be produced either by computationally identifying compounds which have a similar surface to the DDAH, or by computationally designing compounds with surfaces which are likely to bind a substrate or product. Various methods can be used to produce a three dimensional surface which is the same or similar to the surface of a chemical entity which will bind DDAH or DI, preferably at the active site. Based on this shape, packages such as Catalyst/SHAPE • and Catalyst/COMPARE can be used to select compounds from databases which have a similar three dimensional shape. Thus chemical entities which bind a DDAH or DI, for example, can be produced either by computationally identifying compounds which have a similar surface, or by computationally designing compounds with surfaces which are likely to bind to a DDAH or a DI. The success of both database and de novo methods for identifying compounds with activities similar to the compound of interest depends on the identification of the functionally relevant portion of the compound of interest. For a chemical entity that interacts with a DDAH or DI, the functionally relevant portion is referred to as a pharhacophore. A pharmacophore is an arrangement of structural features and functional groups important for biological activity. Similarly, one can identify one or more pharmacophores for a given chemical entity which binds to a DDAH or a DI. In this case, the pharmacophore is a group of atoms that play an important role in binding to a DDAH or DI and thus for activation or inhibition of a DDAH of DI, for example. The data provided herein, concerning the structures of a DDAH and the structure of a DDAH bound to a substrate permits the identification of pharmacophores important for binding to arginine-modifying enzymes, in particular to a DDAH or a DI. Programs suitable for pharmacophore selection and design include DISCO (Abbott Laboratories, Abbott Park, IL) and catalyst (Bio-CAD Coφ., Mountain view, CA). Databases of chemical structures are available from Cambridge Crystallograp iic Data Centre (Cambridge, UK) and Chemical Abstracts Service (Columbus, OH). De novo design programs include Ludi (Biosym Technologies Inc., San Diego, CA) and Aladdin (Daylight Chemical Information Systems, Irvine, CA). Such programs are well known to ' those skilled in the art. Packages such as DBServerl and HipHop can be used to search databases for compounds whose surfaces are described by similar pharmacophores. Once a chemical entity has been designed or selected by the above methods, the efficiency with which that entity binds a DDAH or a DI, a substrate or a product may be tested and optimized using computational or experimental evaluation. Various parameters can be optimized depending on the desired result. These include, but are not limited to, specificity, avidity, on/off rates, and other characteristics readily identifiable by those skilled in the art. The computational means may employ packages such as Catalyst/SHAPE, Catalyst/COMPARE, DBServer, HipHop, Ludi and MCSS to evaluate selected modified DDAHs or DIs and new DDAH or DI binding entities. The experimental means may comprise, for example, the colorimetric assay described in Leiper et al., 1999 (supra). Thus, one may optionally make substitutions, deletions, or insertions in some of the components of the DDAH or DI or to the DDAH or DI binding entity in order to improve or modify the binding properties. Generally, initial substitutions are conservative, i.e. the replacement group will have approximately the same size, shape, hydrophobicity and charge as the original component. Such modifications can be computationally or experimentally evaluated in the same manner as the first candidate chemical entities. If necessary, further modifications can be made. This process of evaluating and modifying may be iterated any number of times. Thus, the invention provide a method for identifying, screening, characterising or designing a chemical entity which is a modified DDAH or DI or binds to a DDAH or DI, which method comprises comparing a structural model of the DDAH or DI with a structural model for said chemical entity, and thereby determining whether said chemical entity is likely to bind to or mimic the DDAH or DI, wherein said structural model of the DDAH or DI is derived from structural coordinates determined by subjecting to X-Ray diffraction measurements a crystal comprising a DDAH or a DI. The invention also provides a chemical entity identified by a method of the invention for identifying, screening, characterising or designing a chemical entity. A chemical entity identified in the invention, for example by a use accordmg to the invention or by a method of the invention for identifying, .screening, characterizing or designing a chemical entity which is a modified DDAH or a modified DI or binds to a DDAH or DI, may be used in the treatment of medical or veterinary conditions. Thus, the invention provides chemical entities for use in a method of treatment of the human or animal body by therapy. In particular, they may be used in a method of treatment of a condition in which the abnormal metabolism of NO is implicated. A chemical entity identified in the invention may also be used for the manufacture of a medicament for use in the treatment of a condition in which the abnormal metabolism of NO is implicated. The condition of a patient suffering from that type of condition can be improved by administration of a chemical entity identified in the invention. A therapeutically effective amount of a chemical entity identified in the invention may be given to a human patient in need thereof. A chemical entity which is an activator of a DDAH may be used in the treatment of conditions in which reduced NO production is implicated. In particular such conditions as hyperlipidaemia, renal failure, hypertension, restenosis after angioplasty, complications of heart failure, or atherosclerosis and its complications may be treated and patients with schizophrenia, multiple sclerosis or cancer may also be treated. A modified DDAH which shows increased DDAH activity in comparison to its corresponding wild-type DDAH may also be used in the treatment of the above conditions. A chemical entity which is an inhibitor of a DDAH may be used in the treatment of conditions in which increased NO production is implicated. In particular, conditions such as ischeamia-reperfusion injury of the brain or heart, cancer, lethal hypotension in severe inflammatory conditions such as septic shock or multi-organ failure, or local and systemic inflammatory disorders including arthritis, skin disorders, inflammatory cardiac disease or migraine may be treated. Alternatively, a chemical entity which is an inhibitor of a DDAH could be used as a joint therapy together with an inhibitor of NOS activity (for example, a methylarginine). For example, a specific inhibitor of a DDAH isoform could be used with the methylarginine L-NMMA. This approach may radically alter the activity profile of L-NMMA and may result in L-NMMA having an increased inhibitory effect for a specific NOS isoform. Thus, the invention provides products containing an inhibitor of a DDAH activity and/or expression and a methylarginine as a combined preparation for simultaneous, separate or sequential use in the treatment of ischeamia-reperfusion injury of the brain or heart, cancer, lethal hypotension in severe inflammatory conditions such as septic shock or multi-organ failure, or local and systemic inflammatory disorders including arthritis, skin disorders, inflammatory cardiac disease or migraine. A chemical entity which is an inhibitor of a DDAH or a DI may also be used as an antimicrobial agent, for example an antibacterial agent. Therefore, the invention also provides a chemical entity for use in the treatment of a bacterial infection. The formulation of a chemical entity of the invention will depend upon factors such as the nature of the exact antagonist, whether a pharmaceutical or veterinary use is intended, etc. A product of the invention may be formulated for simultaneous, separate or sequential use. A product of the invention is typically formulated for administration in the present invention with a pharmaceutically acceptable carrier or diluent. The pharmaceutical carrier or diluent may be, for example, an isotonic solution. For example, solid oral forms may contain, together with the active compound, diluents, e.g. lactose, dextrose, saccharose, cellulose, corn starch or potato starch; lubricants, e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols; binding agents; e.g. starches, gum arabic, gelatin, methylcellulose, carboxymethylcellulose or pofyvinyl pyrrolidone; disaggregating agents, e.g. starch, alginic acid, alginates or sodium starch glycolate; effervescing mixtures; dyestuffs; sweeteners; wetting agents, such as lecithin, poiysorbates, laurylsulphates; and, in general, non-toxic and pharmacologically inactive substances used in pharmaceutical formulations. Such 'pharmaceutical preparations may be manufactured in known manner, for example, by means of mixing, granulating, tabletting, sugar-coating, or film-coating processes. Liquid dispersions for oral administration may be syrups, emulsions or suspensions. The syrups may contain as carriers, for example, saccharose or saccharose with glycerine and or mannitol and/or sorbitol. Suspensions and emulsions may contain as carrier, for example a natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethylcellulose, or poly vinyl alcohol. The suspensions or solutions for intramuscular injections may contain, together with the active compound, a pharmaceutically acceptable carrier, e.g. sterile water, olive oil, ethyl oleate, glycols, e.g. propylene glycol, and if desired, a suitable amount of lidnocaine hydrochlori.de. Solutions for intravenous administration or infusion may contain as carrier, for example, sterile water or preferably they may be in the form of sterile, aqueous, isotonic saline solutions. A therapeutically effective amount of product of the invention is administered to a patient. The does of a product of the invention may be determined according to various parameters, especially according to the substance used; the age, weight and condition of the patient to be treated; the route of administration; and the required regimen. Again, a physician will be able to determine the required route of administration and dosage for any particular patient. A typical daily dose is from about 0.1 to 50 mg per kg of body weight, according to the activity of the specific inhibitor, the age, weight and conditions of the subject to be treated, the type and severity of the degeneration and the frequency and route of administration. Preferably, daily dosage levels are from 5 mg to 2 g. The mvention allows for the identification, screening, characterisation, design or modification of chemical entities which effect specific regulation a particular isoform DDAH and thus of NOS. Chemical entities which have effects specific for one particular DDAH isoform, for example a DDAHI or a DDAHII, may be administered non-specifically as they will only modulate the expression or activity of a particular methylarginase and thus the activity of one particular isoform of NOS. " Chemical entities which are peptides or polypeptides may be administered in the form of a naked nucleic acid construct. Uptake of naked nucleic acid constructs by mammalian cells is enhanced by several known transfection techniques for example those including the use of transfection agents. Example of these agents include cationic agents (for example calcium phosphate and DEAE-dextran) and lipofectants TM TM (for example lipofectam and transfectam ). Typically, nucleic acid constructs are mixed with the transfection agent to produce a composition. Preferably the naked nucleic acid construct, viral vector comprising the polynucleotide or composition is combined with a pharmaceutically acceptable carrier or diluent to produce a pharmaceutical composition. Suitable carriers and diluents include isotonic saline solutions, for example phosphate- buffered saline. The composition may be formulated for parenteral, intramuscular, intravenous, subcutaneous, or transdermal administration. The pharmaceutical composition is administered in such a way that the polynucleotide of the invention, viral vector for gene therapy, can be incoφorated into cells at an appropriate area. When the polynucleotide of the invention is delivered to cells by a viral vector, the amount of virus administered is in the range of 6 ■ 1 f) 7 Q 8 from 10 to 10 pfu, preferably from 10 to 10 pfu, more preferably about 10 pfu for adenoviral vectors. When injected, typically 1-2 ml of virus in a pharmaceutically acceptable suitable carrier or diluent is administered. When the polynucleotide of the invention is administered as a naked nucleic acid, the amount of nucleic acid administered is typically in the range of from 1 μg to 10 mg. Where the polynucleotide giving rise to the product is under the control of an inducible promoter, it may only be necessary to induce gene expression for the duration of the treatment. Once the condition has been treated, the inducer is removed and expression of the polypeptide of the invention ceases. This will clearly have clinical advantages. Such a system may, for example, involve administering the antibiotic tetracychne, to activate gene expression via its effect on the tet repressor/VP16 fusion protein. The use of tissue-specific promoters will be of assistance in the treatment of disease using the polypeptides, polynucleotide and vectors of the invention. It will be advantageous to be able express therapeutic genes in only the relevant affected cell types, especially where such genes are toxic when expressed in other cell types. The routes of administration and dosages described above are intended only as a guide since a skilled physician will be able to determine readily the optimum route of administration and dosage for any particular patient and condition. Chemical entities identified in the invention may be used in a method of diagnosis carried out on the human or animal body. Thus, a modified DDAH, for example an inactive modified DDAH, can be used to assay for the concentration of asymmetric me ylarginines, for example ADMA, in a sample obtained from a subject. This may provide an indication of the status of a subject with respect to a particular medical condition, for example it may indicate whether or not the subject is suffering from a cardiovascular disease. Suitable samples include any body fluid, for example blood, urine or saliva. In addition, tissue samples may be used, for example a blood vessel biopsy. It will be apparent to those skilled in the art how such assays may be carried out. A modified DDAH, for example an inactive modified DDAH, may also be used for in vivo asymmetric methylarginine imaging. Generally, the modified DDAH is be labelled in such an application. Chemical entities identified in the invention may also be used in a method for identifying the presence or absence of an asymmetrically methylated arginine derivative, for example ADMA, in a sample. The method comprises contacting the sample with a modified DDAH and determining whether the modified DDAH binds to an asymmetrically methylated arginine derivative. The method could be applied in the context of a radioimmunoassay or a ligand binding assay. Suitableassay formats are well known to those skilled in the art. The modified DDAH is preferably an inactive modified DDAH. Similar methods may be carried out with a modified DI in order to determine the presence or absence of arginine in a sample. The invention also provides a crystal comprising a DDAH or a fragment thereof or a DI or a fragment thereof. The DDAH or DI may be any DDAH or DI, for example one which is described above. The DDAH or DI may be crystallised in combination with its substrate or its product. The crystal may have the data statistics set out in Table I. Alternatively or in addition, the crystal may have the structural coordinates set out in Table JX The invention also provides a DDAH or a DI. A DDAH or a DI of the invention is preferably one which has been identified, designed and/or modified by use of the structural coordinates obtained by subjecting a crystal of the invention to X-ray diffraction. Preferred DDAHs or DIs are those which have been inactivated. Examples of such DDAHs or Dis are those in which an amino acid equivalent to El 14, H162 or C249 in the PaDDAH is replaced by a different amino acid. The term "equivalent" in this context is explained above. Preferably, the different amino acid is alanine or a sterically similar residue. Other residues which form part of the active pocket and stabilise its structure include those equivalent to D60, F63, E65, D66, R85, E88, D117, R132, L161, 1243, K164, S248, S251, L252 and R253 in the PaDDAH sequence. Thus, the invention provides a DDAH which is mutated, for example substituted, at one or more residues corresponding to one of the above list. Two types of mutation are favoured which may provide inactive DDAHs or DIs: (i) substitution of a residue which hydrogen bonds directly to the substrate, such those equivalent to D66 and E65 in the PaDDAH sequence, with a basic residue; and (ii) substitution of hydrophobic residues, such as those equivalent to F63 and L161 which contact the hydrophobic - part of the ligand either to block the active site or to provide less favourable interactions. More extensive mutation, for example changing the length of the flexible loops surrounding the active site cleft could also be used to affect activity of a DDAH or a DI. A DDAH or DI of the invention may be used to prepare a crystal of the invention which is then subjected to X-ray diffraction measurements according to a use of the invention. The invention further provides a polynucleotide which encodes a DDAH or a DI of the invention and a vector which contains that polynucleotide. A polynucleotide of the invention can be used to prepare a construct wherein the polynucleotide is operably linked to a promoter. Such a construct can then be used to transform or transfect a cell. Such cells may be used to over-express a DDAH or a DI of the invention. The DDAH or DI so-expressed may be used to prepare a crystal and that crystal used according to the invention to identify, screen, characterise, design or modify a chemical entity. Suitable promoters and cells are described above. The invention also provides a method for preparing a crystal of the invention. The method comprises crystallizing a substance comprising a DDAH or a fragment thereof or a DI or a fragment thereof. The DDAH or DI may be a DDAH or a DI of the invention. The following Example illustrates the invention: Example Materials and methods Preparation of P.a DDAH. Samples of wild-type ΛzDDAH and the C249S mutant form were produced for crystallisation as described below. BL21(DE3) cells (Novagen Inc.) transformed with pPROX.Hta αDDAH or pPROX.Hta. αDDAH-C249S were grown at 30°C in Luria-Bertani medium with carbenicillin (lOOμg/ml) to an optimal density of 0.8 at 600nm, before induction with 0.5mM IPTG. Cultures were harvested by centrifugation after 4-6 hrs. For biosynthetic-labelling of PaDDAH with seleno- methionine, B834(DE3) cells transformed with pPROX.Hta.DDAH were grown at 30°C in minimal medium supplemented with selenomethionine, and induced as described above and harvested after 12 hrs. Cell-pellets were resuspended in 25 ml of buffer A (50 mM NaH 2 PO 4 , 10 mM imidazaole, 0.3 M NaCl, 5 mM b- mercaptoethanol, 1 mM PMSF, 5 M benzamidine, adjusted to pH 8.0 with NaOH) and frozen at -80°C. DNAasel was added to the thawed cell suspension to lOμg/ml, before disrupting the cells by French-press (Spectronic Instruments Inc.). The cell- lysate was centrifuged at 40,000 g for 30 mins. at 4°C. The lysate supernatant was purified on a Ni-NTA (Qiagen Inc.) column (V t = 10 ml, d ; = 16mm), by washing in 100 ml of buffer A and then 100 ml of buffer B (as buffer A, but with 50 mM imadazole pH 8.0), before step-elution with 50 ml of buffer C (as buffer A, but with 250 mM imidazole). EDTA (10 mM) was added to the DDAH pool, before further purification by gel-filtration on a Superdex 200 column (V, = 100 ml, d ; = 16mm) ' equilibrated in 20 mM Tris pH 8.0, 100 mM NaCl, 10 mM DTT. The purified DDAH pool was then digested with rTEV protease (Gibco-BRL) at room temperature overnight, using 500U rTEV per 10 mg P DDAH. The cleaved 6His-tag and rTEV were removed by batch adsorption onto 2 ml of Ni-NTA agarose at 4°C. P DDAH was then re-purified by gel filtration. The de-tagged P DDAH pool was then buffer-exchanged into 25 mM Tris, 10 mM DTT pH 8.0 using a Vivaspin centrifugal concentrator (Sartorius) then concentrated to 14 mg/ml. A final yield of 10-15 mg of P DDAH per litre of original culture was obtained. Protein concentrations of purified PaDDAH samples were estimated by absorbance measurements at 280nm. The extinction coefficient of PaDDAH was calculated to be 12,960 M "1 cm "1 using the program "Peptidesort" (GCG Inc.). Bio-physical analysis. Mass spectra were collected on a VG Platform Electrospray Mass Spectrometer (Micromass). Samples were desalted by ultrafiltration into de-ionised water. Samples were then injected (lOμl) under standard conditions (80-200 pmol/μl in 50% acetonitrile, 0.25% formic acid). Delivery solvent (50% acetonitrile) was pumped at a flow rate of lOμl/min. Twelve 10 second scans were accumulated for each-sample over the m/z range 750 - 1150. Source temperature was set at 45°C and the cone voltage was 41 volts. Spectra were processed using the 'Masslynx' software supplied with the instrument (version 3.0 b5). Horse heart myoglobin was used to calibrate the instrument (M r = 16951.5 as determined by (Ashton et al.,1994). The masses of "de-tagged" wild-type and C249S mutant PaDDAH constructs were calculated to be 29,217 and 29,201 respectively. The observed masses matched the calculated masses to within experimental error (4 mass units) and indicated that both samples were essentially homogeneous. Analytical gel-filtration and dynamic light scattering were used to estimate the apparent molecular weight and oligomeric state of PaDDAH over a range of protein concentrations. Both analyses suggested that DDAH was dimeric in solution over the concentration range of 0.1 - 10 mg/ml. Analytical gel-filtration chromatography was performed using a Superdex 200HR column (10/30) (Amersham-Pharmacia Biotech), equilibrated in 25 mM Tris, 100 mM NaCl, pH 7.0, 5 mM DTT at a flow-rate of 0.5 ml/min, using 100 μl sample volumes at 0.1, 1.0 and 10 mg/ml protein concentration. The column was calibrated with a range of protein molecular weight standards to allow estimation of apparent molecular mass (Preneta, 1990). Dynamic light scattering measurements were obtained using a DynaPro-801 instrument equipped with a lOOμl cell (Protein Solutions, Charlottesville, VA). Samples of P DDAH, at concentrations of 0.5, 2.0, 6.0 and 12 mg/ml in 25 mM Tris, 100 mM NaCl, pH 7.0, 5 mM DTT buffer, were passed through 0.2μm membrane filters (Whatman, UK) during injection. Measurements were taken at room temperature according to the manufacturer's instructions, and data was analysed using 'Autopro' software. The program allowed calculation of the translational diffusion coefficient, D, which was converted into apparent Stokes radii, Rs app via the Stokes-Einstein equation: Rs,app = kT 16πη Q D where k is the Boltzman constant, 7" the temperature in degrees Kelvin and 77 0 the solvent viscosity that was assumed to be that of water. The instrument was calibrated with a set of twenty-three standard proteins ranging in size from 8- 1250k in M_, allowing reliable estimation of molecular mass from measurements of diffusion coefficients. The photon count-rate varied by less than 3% in all experiments. Sum of squares errors for all readings were less than 1.0 indicating that the data was of high quality with a high signal to noise ratio. Analytical gel-filtration and dynamic light scattering were used to estimate the apparent molecular weight and oligomeric state of P DDAH over a range of protein concentrations. Both analyses suggested that DDAH was dimeric in solution over the concentration range of 0.1-10 mg ml. There was some evidence of a reduction in apparent molecular weight as the protein concentration was decreased suggesting some degree of dissociation of dimer. In addition dynamic light scattering data indicated that PaDDAH existed as an essentially mono-dispersed dimer at a protein concentration of 12mg/ml. Site-directed mutagenesis The open reading frame of Pseudomonas DDAH was cloned in frame downstream of the polyhistidine and linker sequences of the plasmid pProEX HTa (Life Technologies). Recombinant plasmids were transfected into competent E. coli DH5α which were seeded into liquid cultures. When cultures had reached an OD of 0.5 protein expression was induced by the addition of IPTG (final cone ImM). Two hours post induction cells were harvested by centrifugation and lysed by sonication. Cytosolic protein was separated from cell debris by centrifugation and recombinant protein was purified by affinity chromatography (Nickel agarose binding to polyhistidine tag) followed by size fractionation. The polyhistidine and linker sequences were removed by proteolysis with recombinant tobacco envelope virus protease (Life technologies). Site-directed mutagenesis was performed using a PCR based method. Complimentary oligonucleotides (forward and reverse) encoding the desired nucleotide substitution were designed. In separate PCR reactions, using cloned PaDDAH as the template, each of the mutagentic oligonucleotide was included with a primer complimentary to flanking vector sequences. The products of the two PCR reactions were gel purified, combined and the entire open reading frame was then amplified using the two vector primers previously included in the initial PCR reactions. PCR products were cloned into pProEX HTa and sequenced to verify the correct sequence. Activity of the mutants was determined by the colorimetric assay described in Leiper et al. (1999), Biochem. J. 343, 209-214. Crystallography Crystallization. All crystals were grown at room temperature by the sitting drop method using 1.5 μl of each of the protein solution and the well solution per drop. For the native-and the SeMet derivatives the protein stock solution was betweenl2 and 14 mg/ml in 50mM Tris buffer, pH 8 with 5mM DTT. For the co- crystallisation of mutant protein, ligand at a concentration giving 10-15:1 molar ratio was added to the protein solution. The well solutions were in the range 0.1M Tris pH8.5, 0.15 - 0.3M Na acetate, 25-35% w/v PEG4000. Data Collection. Experimental details and data statistics for native, SeMet, citrulline- and ADMA-cocrystallised datasets are given in Table I. Data processing was with MOSFLM (Leslie, 1992, Joint CCP4 and ESF-EAMCB Newsletter on Protein Crystallography, No 26) and subsequent calculations used the CCP4 programs (CCP4, 1994, Collaborative Computing Project, Number 4. The CCP4 suite: programs for computational crystallography. Acta Crystallographica D, 50, 760-763.). Structure solution and refinement. The structure of the SeMet derivative of PaDDAH was solved by using SOLVE (Terwiliger and Berendzen, 1999, Automated structure solution for MIR and MAD. Acta Crystallographica D55, 849-861) using the MAD dataset. This revealed 10 out of a possible 14 Se sites, which were grouped in two sets of five related by a two-fold axis. Use of density modification and twofold averaging in the program DM (Cowtan, 1994) produced a map in which most of the mainchain could be traced, with the help of the Se sites as landmarks. Native PaDDAH and the SeMet derivative crystallise in the same space group, but do not scale well together. The structure of native PaDDAH was solved by using the phases obtained from SOLVE for the SeMet derivative with the native F's as input to density modification and two-fold averaging in DM. This showed a dimeric structure essentially the same as that of SeMet derivative, but with a small displacement of one molecule of the dimer. The same reflection set was used for cross-validation (R^ ^ ) calculation in both the native and SeMet datasets. • Co-crystallisations of C249S PaDDAH with citrulline and ADMA each produced crystal of different habit from the native, and with higher resolution diffraction. This is reflected in the overall B values from a Wilson .plot of 16 and 18 A 2 respectively, compared with 40 A 2 for both the native and SeMet datasets. The citrulline- and ADMA-containing C249S mutant crystals were in space group C2 (1 molecule/asymmetric unit) and P21 (4molecules/asymmetric unit) respectively, and they were each solved by molecular replacement using a partly refined native structure in AmoRe (Navaza, 1994, AmoRe: an Automated package for molecular replacement. Acta Crystallographica A, 50, 157-163.). The cell dimensions of the ADMA-containing crystals show similarity to that of the native, while the cell for the citrulline derivative is not obviously related. Model building was done with the program O (Jones et al., 1991, Improved methods ' for building protein models in electron density maps and the location of errors in these models. Acta Cryst. A, 47, 110-119.) and refinement with refmac (Murshodov, et al., 1991, Refinement of Macromolecular Structures by the Maximum Likelihood Method. Acta Crystallographica D, 53, 240-255). In all the structure there is a cis- Pro at llO. In the C249S-citrulline and C249S-ADMA structures, all the residues are within allowed regions of the Ramachandran plot except El 71, which precedes the phi-positive HI 72. These residues are in a loop region, but the electron density is unambiguous, although no functional reason has yet been discerned. Results The DDAH fold The crystal structure of DDAH from Pseudomonas aeruginosa residues 0 to 254 as the selenomethioinine derivative was solved by MAD methods at 2.4 A resolution. Amino-terminal residues that had been cloned to the N terminus are not seen in the electron density map. The phases from the Se-substructure were used to solve the native enzyme at 2.4 A resolution. Coordinates from the native structure were used as the model to solve the structures of a C249S mutant co-crystallized with ADMA at 2.0 A resolution and with citrulline at 1.8 A resolution by molecular replacement. The structure coordinates for the native PaDDAH are set out in Table II and the structure coordinates of C249S co-crystallized with citrulline are set out in Table III. The overall fold of Pseudomonas aeruginosa DDAH (PaDDAH) shown comprises a type of barrel formed from 5 modules of a weakly conserved ββαβ structural motif which enclose the active site. The N- and C- termini protrude from one ("bottom") end of the barrel, and at the other ("top") end loop regions surround the active site entrance. Within each β λ β 2 aβ 3 module the three strands are approximately parallel to the barrel axis and arranged as a sheet with β, (inside the barrel) antiparaUel to β 2 , which in turn is parallel to β 3 (on the outside of the barrel); the helix lies on a face of the sheet. There are more or less elaborate loops between these secondary structural elements. Module 1 comprises residues 0-67, and the C-terminal strand 249-254, acting ' as β,; module2, residues 68-117; module3, residues 118-166; module 4, residues 167-205; and module 5(residues 206-248). As predicted by both inspection of alignment from PSIBLAST (Altschul et al., 1997, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402.) and the 3D-PSSM fold prediction server (Kelley et al, 2000, Enhanced genome annotation using structural profiles in the program 3D-PSSM. J. Mol. Biol. 299, 501-522), the DDAH fold is related to that of human L-argine: glycine amindinotransferase (AT, DPB code ljdw), although PaDDAH is much smaller (254 as opposed to 360 amino acid residues) and the sequence identity between human DDAHI and AT is 18%. A superposition of the Cα traces of PaDDAH and AT is shown in; the rms based on 217 equivalent Cα atoms is 1.8A. Module 4 is particularly sketchy, with the alpha helix represented by four residues in a 3 I0 helical conformation . However there is a clear correspondence between the catalytic residues of AT (C407, H303, D254) and C249, H162 and El 14 of DDAH. Interestingly, these residues and the mechanistically important D66 are all found to lie in roughly the same position with respect to the module-structure, on a kinked region immediately preceding strand β, at the same level inside the barrel. Dimer formation Both AT and DDAH are dimeric in the crystal, and DDAH has been shown to be dimeric in solution by analytical gel-filtration and dynamic light scattering (see Experimental section). In each of the crystal forms in the present study the dimer is formed in the same manner, so that it is less likely to be a crystallisation artefact. At the heart of each dimer is the interaction of a strand on the exterior of the barrel with its equivalent around a two-fold axis. In DDAH this is strand β 3 of module 1 (residues 48 to 53), whereas in AT it is strand β 3 of module 2 (residues 209-212), leading to different spatial arrangements of the protomers in their respective dimers. Calculation of accessible surface areas for DDAH monomers and dimers in GRASP give a mean buried area per protomer at the interface of 1154 A 2 ' which is within the limits for a protein of this molecular weight (Jones and Thornton, 1995, Protein- Protein Interactions: A Review of Protein Dimer Structures In Progress in Biophysics and Molecular Biology, 63, 31-165.). The AT interface is more elaborate than that of DDAH, and involves additional residues from modules 1 and 3 (Humm etal., 1997, Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis. EMBO J. 16, 3373-85.); the surface area/protomer buried on dimer formation is 1773 A 2 in AT. The angle between the approximate 5 -fold axis in the barrel and the dimer axis is different in AT and DDAH. In AT these-axes are almost parallel, and it was suggested that this enables the N-terminal residues to protrude on the same side of the dimer and to act as a membrane anchor. In DDAH the two-fold axis is more tilted with respect to the barrel axis, so that the chain termini are more widely separated., which is consistent with its predominantly cyctosolic location (Birdsey et al., 2000, Inτracellular localization of dimethylarginine dimethylaminohydrolase overexpressed in an endothelial cell line. Acta Physiol. Scand. 168, 73-79.). The angle between the two interface strands is likewise significantly different in AT and DDAH. In DDAH there are two pairs of hydrogen bonds across the twofold axis, so that a 6-membered beta sheet is formed form the two adjacent 3- stranded βιβ 2 β 3 sheets of the protomers. In AT .the angle between the two strands is too large for continuous beta sheet formation, and the central strands interact at a single residue, with most of the interface contacts contributed by residues from parts of the structure not present in DDAH. A similar variation in homodimers of very similar enzymes is reported in a structure of a prokaryotic superoxide dismutase (SOD) compared with the eukaryotic SODs (Bourne etal., 1996, Novel dimeric interface and electrostatic recognition in bacterial Cu, Zn superoxide dismutase. Prog. Natl. Acad. Sci. USA 93, 12774-12779.). Both enzymes have the same fold and function but different strands from the Greek key β-barrel are used in the two interfaces, and different electrostatic substrate guidance is postulated. DDAH and AT are much more distantly related than the two form of SOD, but there is the intriguing question of whether they diverged from a common ancestor by the formation of two different dimers in response to different cellular localisation as well as different substrate specificity. The DDAH active site The active site of the SeMet derivative shows no density unaccounted for by protem atoms. The native form has density that may be β-mercaptoethanol, analogous to that found in one of the preparations of AT (PDB code ljdw). The citrulline co-crystallisation experiment contains a very clear citrulline molecule in difference density where it had not been included in the model. The ADMA co- crystallisation experiment gave crystals with four molecules in the asymmetric unit. Much of the structure could be built into an averaged map, and the averaged difference map for the ligand shows the methyl groups of ADMA to be present. However, on refinement they have somewhat higher temperature factors than the rest of the ADMA molecule, which may be the result either of movement, or of a slow turnover of the ADMA resulting in the active sites being occupied partly by ADMA and partly by the product, citrulline. As might be expected there is no evidence of dimethylamine, the other product of the reaction. Ligand binding in DDAH Identification of the active site residues permitted the production of the mutants C249S, H162F and El 14Q. All three mutants were shown to be inactive by in vitro assays. Co-crystallisation of the active site mutant C249S PaDDAH with ADMA (substrate) and citrulline (product/inhibitor) has provided evidence for the binding modes at the extreme of the reaction. Comparison of the binding site with that of -urgimne- in AT shows that the ligand has changed orientation with respect to the active site cavity by about 80°, preserving the orientation of the scissile bond. For this reason we propose a similar mechanism, involving nucleophilic attack by the S atom of C249 on the carbon atom of the guanidino group of dimethylarginine. The slight deviation from planarity of the substituted guanidino group may be induced by the binding of the substrate in the active site, and would increase the susceptibility of this bond to cleavage. The DDAH site lies in a negatively charged cleft at the centre of the barrel. In the apo-form of the enzyme this site is open but In the presence of ligand, either substrate (ADMA) and product inhibitor (citrulline), the active site is occluded by the folding down of a loop between residues 14 and 27 whose extremity is H22. This flap is very mobile/disordered in the apo-form of the protein, but becomes more ordered, with a concomitant increase in resolution of the diffraction, on binding ADMA or citrulline. There is a single direct contact between the ligand (ADMA or citrulline) and the flap: the carbonyl O of Leu 18 binds the peptide N of ADMA. The sidechain of D60 also bridges between N of ADMA, and N of LI 8 (does in ADMA - check CIT. The flap region is quite variable amongst DDAHs from different species, and there is a one-residue insertion here in mammalian DDAH compared with PaDDAH, so this contact is presumably a late event in ligand binding, rather than a driving force. This flap movement is in an opposite sense from that in AT, where the "" binding of L-arginine induces an open conformation. The catalytic residues are supplied by three different modules of the sequence: El 14 by module 3, H162 by module 4 and C249 by module 5. They all lie in the linker regions between strand β 3 of one their motif and strand β ; of the next. El 14 and H162 immediately precede small 3 10 helices, and C249 is also in a helical conformation. Within the active site, a network of hydrogen bonds holds the ligand in place, with the C249 of the catalytic triad on one side, and HI 62, El 14 on the other. The peptide end of the molecule forms hydro gen bonds to the O atoms of LI 8 and 1243, and to the sidechains of R132 and D60. The hydrophobic part of the DDAH extended backbone is protected from the charged residue around the cleft by the sidechains of F63 and LI 61. The guanidinium end of the ADMA is hydrogen bonded to D66, which bridges Ne and the non-methylated N G ', and the H-bonding is similar in the ' citrulline complex. There is an extensive network of hydrogen bonds surrounding the active site • cleft, which stabilises the relationships between the secondary structure elements, the ligand and the catalytic residues. Comparison of the DDAH active site with that of amidinotransferase Having the scissile bond in the same orientation in the DDAH and AT complexes means that the backbones of the two ligands are differently disposed with respect to the active site residues, with an angle between them of about 80 deg. This also has the result that some residues, while apparently conserved between the two enzymes, actually have slightly different roles. D66(PaDDAH) and its sequential equivalent D170(AT) both make contact with their ligand, but D66(PADDAH) makes two hydrogen bonds rather than one, effectively locking the guanidino group in place. The D at this position is conserved in all DDAH sequences except M tuberculosis, and in the AT family. D66 is held in place by R85 (R189) and E88 (El 92). R85 and E88 are conserved in all know DDAH and AT sequences. The equivalent dual hydrogen-bonding function to D66 is carried out by D305 in AT, which is conserved in known AT sequences. The sequentially equivalent residue to AT's D305 in PaDDAH is R164, which is K or R in known DDAH sequences (except M tuberculosis), and whose side-chain does not make contact with the ligand. The sidechain of E65 forms a hydrogen bond to NG' of ADMA, and is mainly conserved in the DDAH sequences; this aligns with the conserved Rl 69 in AT, whose sidechain is directed awat from the arginine ligand; the equivalent bond is formed by D170 of AT, which is conserved in that family. Residues involved in hydrogen bonding to the peptide end of the ligand are quite different in DDAH and AT. Interactions with the mainchain of LI 8 are mentioned above;' another example is D60, whose sidechain in hydrogen-bonded to the N of ADMA, but the equivalent Yl 64 in AT is not in contact with the R ligand. Although the ligand in each complex makes contacts with two hydrophobic sidechains, the residues involved are different: L161 and F63 in DDAH; M302 and L358 in AT. Proposed mechanism Ogawa et al. (1989, Purification and properties of a new enzyme, N G ,N G - dimethylarginine dimethylaminohydrolase, from rat kidney. J. Biol. Chem., 264, 10205-9) showed that DDAH from rat kidney irreversibly converted one molecule of ADMA to one molecule each of L-citrulline and dimethylamine, requiring no co- factors and giving no other product. In the presence of H 2 18 0, 18 O was incorporated onto the ureido group of the citrulline, showing that a hydrolytic step is involved. They showed that somebut not all, SH-blocking agents acted as inhibitors, as did certain divalent metal ions. The structural data suggested that in PaDDAH the catalytic residues are C249, HI 62 and El 14, and this was confirmed by mutations at these three positions which abolished activity. In most of the DDAH sequences the equivalent of El 14 is D, but comparison with the ATstructure, where D is also used, suggests that only minor adjustments are required to allow for the differing sidechain lengths. In the discussion which follows it can be assumed that D could replace El 14 without major changes to the mechanism. The ADMA (substrate) and citrulline (product/inhibitor) are both fixed firmly into the active site by hydrogen bonds. If we denote the methyl-bearing guanidino-nitrogen atom as N G and the hydrogen bearing nitrogen as N G ', the sidechain of D66 hydrogen bonds to both the NE and N G' in both complexes. N G' is also hydrogen-bonded to the sidechain of E65 and both E65 and D66 are held in place by further H-bonds. It is suggested that these bonds serve as a vice to ' hold the substrate in position during the reaction. The OG of S249 (and therefore the SG of native enzyme), the CZ of the substrate and the.ND of HI 62 are in a line perpendicular to the plane of the guanidino group. We hypothesise that the active site Cys and His form a thiolate- imidazoliunium ion pair analogous to that of the cysteine proteases (Storer and Menard, 1994, Catalytic Mechanism in papain family of cysteine peptidases. Methods Enzymol., 244, 486-500). The proposed mechanism then involves nucleophilic attack by SG of C249 on the CZ of the substrate with formation of tetrahedral centres at both CZ and N G which carries. The electron density for the ADMA show some degree of distortion fro planarity here, which would imply a loss of conjugation of the bonds of the guanidino group. Although it is difficult to apportion between twisting and non- planarity at the CZ, N G atoms, it is suggested that the effect would be to increase the reactivity of this bond. Dimethyiamine is released, and diffuses out of the active site, leaving the thiourea oxyanion derivative. In the second part of the reaction, hydrolysis of the intermediate, possibly by a water molecule activated by interaction with HI 62 (there is no obvious general base in the vicinity). Finally collapse of the tetrahedral centre and release of a proton leaves the citrulline bound to active site; its release presumably require a conformational change back to the open form of the enzyme. There is as yet, no definite proof for the formation of an intermediate, and a one-step reaction could be envisaged, but this distinction will require direct observation of an intermediate. DDAH specificity Both ADMA and LMMA will fit into the binding site in DDAH, and both will susceptible to the steric distortion that is proposed to assist in activating the scissile bond. Introduction of SDMA, however, would be hindered both sterically and by the negatively charged environment occupied by the non-methylated N G of ADMA. PaDDAH has been shown to have weak deiminase activity (Santa Maria et al, 1999, Identification of microbial dimethylarginine dimefhylaminohydrolase enzymes. Mol. Microbiol., 33, 1278-1279). It is quite possible to fit arginine in place of ADMA in the active site of DDAH, and it might be expected to bind in the same way. However, the active site of arginine deiminase (see below) is likely to be considerably different from that of DDAH. While ndn-methylated arginine would fit into the bonding pocket, there would be space for one or more water molecules, as found in the citrulline structure, and also there would be less tendency for the guanidinium group to twist to fit in the active site. A closer fit of local residues and the assumption is that a chemical requirement for one of the arginine N G atoms to become the leaving group is not optimised in DDAH. Relationship of the PaDDAH structure to other family members Two questions that arise in considering the relationship of the structure of the active site of PaDDAH to other structures in the family, and its implications for other sequences in the superfamily are (i)Is PaDAAHa good model for human /mammalian DDAH? and (ii) What might the arginine deiminase active site look like? Some of the key residues around the PaDDAH active site, together with their equivalents in arginine: glycine amidinotransferase, arginine nosamine phosphate amidinotransferase ,fhe mammalian DDAH isoforms I and II and arginine deiminase are listed in Table IV. (i)Is PaDAAH a good model for human /mammalian DDAH? In a sequence-based alignment, while the catalytic His and D/E are in register, the catalytic Cys of DDAHII is two residues later than that of the bacterial and DDAHI, so that an adjustment to the preceding loop will be required. This is in contact with the flap region, and may somewhat change its position. The flap region sequence is not conserved in the DDAH sequences, but since the only requirement is for contact of the ligand with a mainchain atom, this is not unexpected. There are, however, quite major large insertions and deletions, particularly in modules 4 and 5, which are likely lead to local structural differences between PaDDAH and mammalian DDAH, while maintaining the overall architecture. Around the active site, most of the PaDDAH residues are conserved in DDAHI and bacterial DDAH. There are one or two surprising positions amongst these residues at which there is no conservation between PaDDAH and the DDAHII isoforms. Two obvious examples are E65, which is G in DDAHII and D60, which is L in DDAHTJ. R132 in DDAHI and bacterial DDAH is W in DDAHII so clearly this is not an essential residue. Futhermore, 132 is spatially close to another mutated residue between DDAHI and 2, G81W, and some degree of repacking will be needed to accommodate these two sidechains in DDAH2. Another feature reported in mammalian DDAH, but not PaDDAH is the presence of a zinc ion, whose function is was speculated to be structural; Zn 2+ also inhibits the enzymatic activity (Bogumil et ah, 1998, Characterization of dimefhylargininase from bovine brain: evidence for a zinc binding site. Biochemistry 37, 4791 -4798.). No evidence of a Zn 2+ ion was found in any of the present structures. The Zn 2+ is thought to bind to cysteine and histidine sidechains, and there are several places where a residue is conserved as one of these in mammalian DDAH but not in the bacterial sequences, including 35, 168, 190, 205 and 214 (PaDDAH numbering). Apart from 35, all of these residues lie in parts of the structure where there are insertions/deletions, and thus expected structural variations, between the PaDDAH and mammalian sequences. So far inspection of the sequences and structure has failed to reveal a possible location for this binding site, although in view of its inhibiting effect it is possible binding involves at least one residue from the active site. (ii) What might the arginine deimnase active site look like ? Arginine deiminase is a bacterial enzyme that catalyses the first step in the arginine dihydrolase pathway, which is an important source of energy in microbes. It catalyses the hydrolysis of arginine to citrulline and ammonia, which involves breaking the equivalent bond to that broken by DDAH. The substrates are not interchangeable, however; rat DDAH was reported to have no arginine deiminase activity (Ogawa et al., 1989, supra) and PADDAH to have only a very low level (Santa Maria et al, 1999, supra). Inspection of the aligned deiminase sequences (Knodler et al., 1998, Clonging and expression fo a prokaryotic enzyme, Arginine deiminase, from a primitive eukaryote Giardia intestinalis. J. Biol. Chem. 273 4470-4477) shows conserved Cys, His and Glu residues in the same order as in DDAH so that it is reasonable to assume that deiminase has a similar catalytic triad and mechanism to DDAH. Homology between DDAH and arginine deiminase has been noted (Leiper et al., 1999, supra), although it is largely confined to the residues between the catalytic Glu and His residues and those immediately adjacent to the catalytic Cys. The sequence length in module 2 is approximately the same as that in PaDDAH, but there is a large insertion in module 4. Table IV shows that the arginine deiminase active site has some of the characteristics of both the DDAH and AT site. A preliminary test for modelling the deiminase active site was made by taking the structure of PaDDAH and making local mutations (residues in brackets are conserved from PaDDAH to PaDEIM); D60N (63F) E65R (66D) (85R) (88E) 117(D) (132R) L161M K164D. The pair of mutations E65R and K164D where the R and D are conserved in the deiminases, are characteristic of the AT rather than the DDAH active site is particularly notable. These sidechains occupy rather different spatial positions in DDAH and AT, so that a rearrangement more complicated than reversal of hydrogen-bonded pair is possible for deiminase. R132 is conserved, and might be thought to have the same function as in the PaDDAH active site; however, the equivalent residue to R132 in human and mouse DDAHII is W, so this position may not be critical. Other mutations which on inspection of the substitutions above seem to be affected by the changes around active site were Y38L, A82W, N204, I206Q, V247G, S248H, S251T, L252Cand R253P but of these only V247G represents a change to a residue conserved in the deiminase family. From graphical inspection of the mutations above, and bearing in mind the differing length of putative loop regions of the molecules, it is quite possible that arginine deiminase has its own unique variant of the active site, possibly with a different flap region and a distinctive orientation of the substrate. How does this structure compare with others with a Cys-His-Asp triad? The catalytic triad of DDAH is reminiscent of that of the cysteine proteases; however, the secondary structure elements in which the are found do not resemble the cysteine proteases. -It is therefore somewhat surprising that manual overlay (using O) of the sidechains of the catalytic triad of DDAH with that of arylamine N-acetyl transferase - a member of the cysteine protease superfamily (Sinclair et al., 2000, Structure of aiylamin N-acetyltransferase reveals a catalytic triad. Nature Struct. Biol. 1, 560-564) -shows that distances between the three equivalent pairs of Cα atoms of 2.9, 2.8 and 1.8 A. However there is no general alignment of secondary structural elements, and the sequence order of the catalytic residues is reversed, so it not likely that they share a common ancestry. This seems to be an example of convergent evolution of a catalytic triad in the cysteine protease superfamily, analogous to the relationship between the serine proteases and other enzymes that have independently evolved a Ser-His-Asp catalytic triad (Dodson, G. and Wlodawer, A, 1998, Catalytic triads and their relatives. TIBS 23, 347-352). How does it compare with other enzymes that process arginine and related molecules? Of the many enzymes involved in arginine synthesis and metabolism (Wu and Morris, 1998, Arginine Metabolism: nitric oxide and beyond. Biochem. J. 336, 1-17) structures are known for NOS (Fischmann et al, 1999, Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation, Nat Struct Biol. 6, 233-42), arginase (Cox et al., 1999, Arginase- boronic acid complex highlights a physiological role in erectile function, Nat Struct Biol. 6, 1043-1047), PRMT3 (Zhang et al, 2000, Crystal structure of the conserved core of protein arginine methyltransferase PRMT3, EMBO J 19, 3509-3519) , argininosuccinate lyase (Turner et al., 1997, Human argininosuccinate lyase: a structural basis for intragenic complementation, Proc Natl Acad Sci U S A 94,9063- 8 ) and AT but apart from AT none bears any resemblance to that of DDAH. There are two enzymes which deiminate arginine, arginine deiminase (EC 3.5.3.6) which acts on free substrate, and which is so far only known so far in bacteria, and protein argiriine deiminase (PAD, EC 3.5.3.15), found mainly in vertebrates, which converts arginine residues in proteins to citrulline in the presence of calcium ion. While DDAH processes free methylarginines, there is so far no equivalent enzyme known which processes rήethylarginine residues in a protein context. There appears to be little similarly between DDAH and protein arginine deiminase, which is not surprising since DDAH buries the substrate, and in a protein context this would not be possible. It has been suggested the PAD has a catalytic Cys residue (McGraw et al., 1999, Purification,characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infection and Immunity 67, 3248-3256), and the presence of a similar catalytic triad seems quite plausible. Table I. X-ray crystallographic data collection Each data set collected on a single cryo-cooled crystal at flash cooled to 100 K in a gaseous nitrogen stream: the cryoprotetant was glycerol for the native dataset and N-paratone for all the others. Table II. Structural Coordinates for the native PaDDAH CRYSTl 86. 030 127 .72C ) 47.340 .90.00 : 90.00 90.00 SCALE1 0.011624 0. 000000 0.000000 0.00000 SCALE2 0.000000 0. 007830 0.000000 0.00000 SCALE3 0.000000 0. 000000 0.021124 0.00000 ATOM 1 N PHE A 0 37.110 33 .687 30.450 1 .00 62 .68 7 N ATOM 2 CA PHE A 0 36.149 32 .847 29.678 1 .00 62 .98 6 C ATOM 3 C PHE A 0 36.358 32 .903 ' 28.163 1 .00 61 .43 6 C ATOM 4 O PHE A 0 37.132 33 .660 27.605 1 .00 62 .94 8 O ATOM 5 CB PHE A ' 0 34.703 33 .264 29.966 1 .00 63 .80 6 C ATOM 6 CG PHE A 0 34.173 34 .358 29.076 1 .00 63 .61 6 C ATOM 7 CD1 PHE A 0 33.061 34 .131 28.298 1 .00 63 .56 6 C ATOM 8 CD2 PHE A 0 34.764 35 .610 29.062 1 .00 63 .57 6 C ATOM 9 CE1 PHE A 0 32.527 35 .152 27.535 1 .00 62 .87 6 C ATOM 10 CE2 PHE A 0 34.202 36 .637 28.329 1 .00 64 .41 6 C ATOM 11 CZ PHE A 0 33.068 36 .408 27.574 1 .00 64 .35 6 C ATOM 12 N MET A 1 35.603 32 .062 27.439 1 .00 58 .44 7 N ATOM 13 CA MET A 1 35.783 32 .081 25.998 1 .00 53 .42 6 C ATOM 14 C MET A 1 34.449 32 .047 25.292 1 .00 48 .80 6 C ATOM 15 O MET A 1 33.389 31 .853 25.845 1 .00 50 .03 8 O ATOM 16 CB MET A 1 36.454 30 .804 25.498 1 .00 57 .14 6 C ATOM 17 CG MET A 1 37.951 30 .805 25.702 1 .00 61 .29 6 C ATOM 18 SD MET A 1 38.708 29. .417 24.809 1 .00 66 .99 16 S ATOM- 19 CE MET A 1 39.150 30. .325 23.302 ' 1 .00 65 .96 6 C ATOM 20 N PHE A 2 34.5.74 32, .175 23.991 1 .00 43 .54 7 N ATOM 21 CA PHE A 2 33.416 32 .043 23.105 1 .00 37 .19 6 C ATOM 22 C PHE A 2 33.709 30. .752 22.331 1, .00 35, .23 6 C ATOM 23 O PHE A 2 34.874 30. .579 21.886 1, .00 32, .49 8 0 ATOM . 24 CB PHE A 2 33.335 33. .2Ϊ4 22.123 1, .00 37, .42 6 C ATOM 25 CG PHE A 2 32.819 34. .501 22.704 1, .00 33, ,48 6 C ATOM 26 CD1 PHE A 2 33.458 35, .678 22.366- 1, ,00 29, .44 6 C ATOM 27 CD2 PHE A 2 31.711 34. ,474 23.575 1. .00 33. .10 6 C ATOM 28 CE1 PHE A 2 33 ,-020 36. .893 22.877 1. .00 27. ,39 ' 6 C ATOM 29 CE2 PHE A 2 31.274 35. .726 24.095 1, .00 34. .33 6 - C ATOM 30 CZ PHE A 2 31.934 36, .904 23.735 1, .00 30, ,88 6 C ATOM 31 N LYS A 3 32.668 29. .943 22.181 1. ,00 32, ,94 7 N ATOM 32 CA LYS A 3 32.808 28. ,711 21.400 1, ,00 32. ,59 6 C ATOM 33 C LYS A 3 32.065 28, ,749 20.052 1. .00 35, ,08 6 C ATOM 34 O LYS A 3 32.259 28. ,005 19.052 1. ,00 31. .22 8 O ATOM 35 CB LYS A 3 • 32.431 27. ,447. 22.171 1. ,00 30, ,87 6 C ATOM 36 CG LYS A 3 33.123 27, ,110 23.406 0, ,00 25. ,00 6 C ATOM 37 CD LYS A 3 ' 32.330 26. ,122 24.242 0. ,00 25. 00 6 C ATOM 38 CE LYS A 3. 33.209 24. ,995 24.748 0. ,00 25. 00 6 C ATOM . 39' NZ LYS A 3 32.549 24. ,234 25.844 0. 00 25. 00 7' N ATOM 40 N HIS A 4 31.068 29. ,690 19.935 1. 00 35. 39 7 N ATOM 41 CA HIS A 4 30.260 29. ,860 18.772 1. 00 30. 13 6 C ATOM 42 C HIS A 4 29.958 31. ,280 18.304 1. ,00 30. 91 6 C ATOM 43 O HIS A 4 29.732 32. 268 18.938 1. 00 28. 72 8 0 ATOM 44 CB HIS A 4 28.797 29. 462 19.108 1. 00 34. 36 6 C ATOM 45 CG HIS A 4 28.839 28. 018 19.476 1. 00 39. 64 6 C ATOM 46 ND1 HIS A 4 29.336 27. 101 18.573 1. 00 38. 50 7 N ATOM 47 CD2 HIS A 4 28.466 27. ,371 20.612 1. 00 39. 75 6 C ATOM 48 CE1 HIS A ' 4 29.267 25. 923 19.138 1. 00 38. 43 6 C ATOM 49 NE2 HIS A 4 28.752 26. 067 20.355 1. 00 40. 69 7 N ATOM 50 N ILE A 5 29.800 31. 417 17.005 1. 00 31. 23 7 N ATOM 51 CA ILE A 5 29.389 32. 546 16.247 1. 00 31. 51 6 C ATOM 52 C ILE A 5 28.206 32. 243 15.338 1. 00 30. 53 6 C ATOM 53 O ILE A 5 28.084 31. 249 .14.667 1. 00 30. 67 8 O ATOM 54 CB ILE A 5 30.530 33. 085 15.378 1. 00 34. 30 6 C ATOM 55 , CGI ILE A 5 31.276 34. 062 16.341 1. 00 34. 58 6 C ATOM 56 CG2 ILE A 5 30.004 33.777 14.108 1.00 33.67 6 C ATOM 57 CD1 ILE A 5 32 .606 34 .306 15 .607 1 .00 39 .67 6 C ATOM 58 N ILE A 6 27 .264 33 .192 15 .221 1 .00 28 .58 7 N ATOM 59 CA ILE A 6 26 .134 33 .025 14 .300 1 .00 23 .15 6 C ATOM 60 .C ILE A 6 26 .183 34 .313 13 .472 1 .00 22 .48 .6 C ATOM 61 O ILE A 6 26 . 466 35 .446 13 .947 1 .00 23 .13 8 O ATOM 62 CB ILE A 6 24 .759 32 .927 14 .927- 1 .00 25 .16 6 C ATOM 63 CGI ILE A 6 24. .637 31 .732 15 .868 1 .00 21 .17 6 C ATOM 64 CG2 ILE A 6 23 .681 33 .013 13 .829 1 .00 21 .42 6 C ATOM 65. CD1 ILE A 6 23 .301 31 .698 16 .628 1 .00 24 .74 6 c ATOM .66 N ALA A 7 26. .027 3 .143 12 .153 1 .00 19 .06 7 N ATOM 67 CA ALA A 7 26 .108 35 .297 11 .282 1 .00 15 .97 6 C ATOM 68 C ALA A 7 25 .239 35 .074 10 .083 1 ..00 17 .69 • 6 C ATOM 69 O ALA A ■ 7 24 .846 33 .925 9 .978 1 .00 16 :o9 8 O ATOM 70 CB ALA A 7 27 .524 35 .450 10 .763 1 .00 16 .42 6 C ATOM 71 N ARG A 8 24, .985 36 .082 9 .225 1 .00 20, .62 7 N ATOM 72 CA ARG A 8 24. .109 35. .758 8 .053 1 .00 21 .09 6 C ATOM 73 ' C ARG A 8 24 .553 36 .478 6 .782 1 .00 20 .84 6 C ATOM 74 O ARG A 8 24 .839 37 .702 6. .814 1 .00 17 .32 8 O ATOM 75 CB ARG A 8 22. .666 36, .241 8 .279 1, .00 23, .39 6 C ATOM 76 CG ARG A 8 21, .636 35. .945 7, .159 1, .00 23, .03 6 C ATOM 77 CD ARG A 8 20, .301 • 36, .641 7, .518 1, .00 24, .04 6 c ATOM 78 NE ARG A 8 19 .582 36 .087 8 .651 1, .00 25, .68 • 7 N ATOM 79 CZ ARG A 8 18 .971 34 .885 8 .561 1 .00 24, .76 6 C ATOM 80 NH1 ARG A 8 19. ,088 34, ,267 7. .381 1. .00 27. ,28 7 N ATOM 81 NH2 ARG A 8 18, .281 ' 34. .175 9. .395 1. .00 21. .38 7 N ATOM 82- N THR A 9 24, .625 35, .788 5, .650 1, .00 19, .75 7 N ATOM 83 CA THR A 9 25, .056 36, .555 4, .443 1, .00 23, .25 6 C ATOM 84 C THR A 9 24. .210 37. .745 4, .160 1. .00 22. .64 6 C ATOM 85 O THR A 9 23. .013 37, .-687 • 4. ,351 1, ,00 23. ,85 8 O ATOM 86 CB THR A 9 24, ,870 35. .591 3. .226 1. .00 23, .90 6 C ATOM 87 OG1 THR A 9 25, .514 34, .403 3, .785 1, .00 27, .68 8 O ATOM 88 CG2 THR A 9 25, ,578 35, ,942 1. ,975 1. ,00 21. ,05 6 C ATOM 89 N PRO A 10 24. ,703 38. ,834 3. .703 1. ,00 24. ,41 ' 7 N ATOM 90 CA PRO A 10 23, ,827 39, ,962 3. ,389 1. ,00 23. ,79 6 C ATOM 91 C PRO A 10 23. ,042 39. ,664 2. ,134 1. ,00 28, ,09 6 C ATOM 92 O PRO A 10 23. .514 39. .037 1. .162 1. ,00 32. ,99 8 O ATOM 93 CB PRO A 10 24, ,760 41. ,053 3. .035 1. ,00 19. ,47 6 C ATOM 94 CG PRO A 10 26. ,019 40. ,404 2. ,602 1, ,00 20. ,50 6 C ATOM 95 CD PRO A 10 26. ,148 39. ,109 3. ,434 1. 00 24. 16 6 C ATOM 96 N ALA A 11 21. ,828 40. ,167 2. ,084 1. 00 • 31. 10 7 N ATOM 97 CA ALA A 11 20. ,890 40. ,076 0, .989 1. ,00 31. ,27 6 C ATOM 98 C ALA A 11 21. ,159 41. ,204 -0. ,030 1. ,00 34. 04 6 C ATOM 99 O ALA A 11 21. ,684 42. ,248 0. ,371 1. ,00 31. 26 8 O ATOM 100 CB ALA A 11 19. 493 40. 259 1. ,531 1. 00 29. 04 6 C ATOM 101 N ARG A 12 20. .754 40. ,944 -1. ,300 1. ,00 30, 79 7 N ATOM 102 CA ARG A 12 20. ,920 41. ,941 -2. ,323 1. ,00 33. 27 6 C ATOM 103 C ARG A 12 19. ,990 43 ' . ,076 -1. ,933 1. 00 32. 96 6 C ATOM 104 O ARG A 12 20. 347 44. ,253 -2. ,024 1. 00 33. 10 8 O ATOM 105 CB ARG A 12 20. 594 41. 530 -3. 765 1. 00 36. 05 6 C ATOM 106 CG ARG A 12 21. ,187 40. ,228 -4. ,223 1. 00 39. 17 6 C ATOM 107 CD ARG A 12 21. .123 39. 985 -5. ,710 0. 00 25. 00 6 C ATOM 108 NE ■ ARG A 12 22. 090 38. 994 -6. ,168 0. 00 25. 00 7 N ATOM 109 CZ ARG A 12 23. 073 39. 249 -7. 020 0. 00 25. 00 6 C ATOM . 110 NH1 ARG A 12 23. 207 40. 464 -7. 531 0. 00 25. 00 7 N ATOM 111 NH2 ARG A 12 23. 921 38. 288 -7. ,356 0. 00 25. 00 7 N ATOM 112 N SER A 13 18. ,819 42. .783 -1. ,322 1. 00 32. 93 7 N ATOM 113 CA SER A 13 18. 020 43. 921 -0. 857 1. 00 33. 79 6 C ATOM 114 C SER A 13 18. 785 44. 852 0. 040 1. 00 39. 59 6 C ATOM 115 O SER A 13 18. 374 46. 016 0. 228 1. 00 42. 25 8 O ATOM 116 CB SER A 13 16. 700 43. 412 -0. 328 1. 00 32. 35 6 C ATOM 117 OG SER A 13 16.791 42.748 0.948 1.00 35.17 8 0 ATOM 118 N LEU A 14 19 .912 44 .484 0 .697 1.00 43 .32 7 N ATOM 119 CA LEU A 14 20 .676 45 .332 1 .583 1.00 45 .46 6 C ATOM 120 C LEU A 14 20 .788 46 .738 0 .996 1.00 47 .96 6 C ATOM 121 ' O LEU A 14 20 .716 47 .698 1 .692 1.00 44 .53 8 O ATOM 122 CB LEU A 14 22 .096 44 .793 1 .759 1.00 46 .15 6 C ATOM 123 CG LEU A 14 22 .962 45 .090 2 .949 1.00 45 .96 6 C ATOM 124 CD1 LEU A 14 24 .020 46 .102 2 .591 1.00 47 .65 6 C ATOM 125 CD2 LEU A 14 22 .107 45 .655 4 .071 1.00 48 .57 6 C ATOM 126 N VAL A 15 21 .070 46 .859 -0 .280 1.00 54 .67 7 N ATOM 127 CA VAL A 15 21 .169 48 .153 -0 .966 ' 1.00 61- .86 6 C ATOM 128 C VAL A 15 19 .771 48 .721 -0. .944 1.00 67 .28 6 C ATOM 129 O VAL A 15 19 .556 49 .441 0 .081 1.00 70 .79 8 O ATOM 130 CB VAL A 15 21 .678 47. .891 -2 .381 1.00 60 .80 6 c ATOM 131 CGI VAL A 15 21 .929 49 .294 ~2 .919 1.00 63 .45 6 c ATOM 132 CG2 VAL A 15 22. .912 47, .035 -2 .279 1.00 58 .69 6 c ATOM 133 N ASP A 16 18 .842 • 48, .423 -1 .873 1.00 69 .66 7 N ATOM 134 CA ASP A 16 17 .492 48, .905 -1 .592 1.00 73 .65 6 c ATOM 135 C ASP A 16 16, .855 50 ' . .146 -2. .118 1.00 73 .96 6 c ATOM 136 O ASP A 16 15, .621 50. .250 -1, .876 1.00 75 .09 8 0 ATOM 137 CB ASP A 16 17, ,256 49, .122 -0, .054 1.00 76, .53 - 6 c ATOM 138 CG ASP A 16 15 .860 48 .741 0 .394 1.00 82 .22 6 c ATOM 139 OD1 ASP A 16 15, .092 47, ,968 -0. .241 1.00. 82 .82 8 0 ATOM 140 OD2 ASP A 16 15, .546 49, .286 1 .479 1.00 85 .01 8 0 ATOM 141 N GLY A 17 17, .524 51, ,084 -2, .769 1.00 74, .31 7 N ATOM • 142 CA GLY A 17 16, .623 52, .176 -3, .163 1.00 74, ,96 6 C ATOM 143 C GLY A 17 17, .373 53, .481 -3. .185 1.00 75, .85 6 C ATOM 144 O GLY A 17 18. .517 53, .424 -3, .636 1.00 77, .64 8 O ATOM 145 N LEU A 18 16. ,650 54. .502 -2, .715 1.00 73. .64 7 N ATOM 146 CA LEU A 18 17. ,295 55. ,813 -2, ,774 1.00 70, .08 6 C ATOM 147 C LEU A 18 18, .278 56. .027 -1. .638 1.00 68. ,32 6 • C ATOM 148 O LEU A 18 17, .945 55. ,924 -0, .463 1.00 69, ,03 ' 8 O ATOM 149 CB LEU A 18 16, .151 56. ,795 -2, .820 1.00 70. .56 6 C ATOM 150 CG LEU A 18 14. .841 56, ,681 -3. .579 1.00 69. ,33 6 C ATOM 151 CD1 LEU A 18 13. .995 57. ,916 -3, .217 1.00 68. ,34 6 C ATOM 152 CD2 LEU A 18 14. ,911 56. ,617 -5, ,082 1.00 66. 83 6 C ATOM 153 N THR A 19 19. .512 56. ,365 -1, .988 1.00 66. ,52 7 N ATOM 154 CA THR A 19 20. .546 56, ,643 -1. ,005 1.00 65. ,07 6 C ATOM 155 C THR A 19 19, .902 57. ,295 0. .227 1.00 66. ,10 6 C ATOM 156 O THR A 19 19. ,108 58. ,245 0, ,141 1.00 65. 68 8 O ATOM. 157 CB THR A 19 21. ,677 57. 462 -1, ,604 1.00 63. 90 6 C ATOM 158 OG1 THR A 19 21, ,561 58. ,804 -1. ,217 1.00 63. 50 8 O ATOM 159 CG2 THR A 19 21. ,645 57. ,367 -3, ,143 1.0Q 65. 35 6 C ATOM 160 N SER A 20 20. .194 56. ,707 1, ,398 1.00 64. 66 7 N ATOM 161 CA SER A 20 19. ,593 57. ,211 2. ,630 1.00 65. 02 6 C ATOM 162 C SER A 20 20. ,526 57. 963 3. 551 1.00 62. 89 6 C ATOM -163 O SER A 20 20 ' . ,022 58. 437 4. 554 1.00 61. 99 8 O ATOM 164 CB SER A 20 18. ,856 56: ,060 3, .322 1.00 67. 58 6 C ATOM 165 OG SER A 20 19. ,502 54. ,832 2. ,929 1.00 71. 93 8 O ATOM 166 N SER A 21 21. ,805 58. 160 3. 316 1.00 61. 78 7 N ATOM 167 CA SER A 21 22. 680 58. 957 4. 149 1.00 61. 68 6 C ATOM 168 C SER A 21 23. ,575 59. 691 3. 137 1.00 59. 24 6 C ATOM 169 O - SER A 21 23. ,748 59. ,187 2. ,029 i.oo 59. 16 8 O ATOM 170 CB SER A. 21 23. ,803 58. 300 5. 015 1.00 62. 18 6 C ATOM 171 OG SER A 21 23. 699 58. 475 6. 401 0.00 30. 00 8 O ATOM 172 N HIS A 22 24. 231 60. ,710 3. 644 1.00 57. 13 7 N ATOM 173 CA HIS A 22 25. ,178 61. 396 2. .806 1.00 58. 09 6 C ATOM 174 C HIS A 22 26. ,417 60. ,508 2. 747 1.00 57. 37 6 C ATOM 175 O HIS- A 22 27. 368 60. 885 2. 076 1.00 58. 77 8 O ATOM 176 CB HIS A 22 25. 613 62. 720 3. 444 1.00 62. 64 6 c ATOM ' 177 CG HIS A 22 26. 243 62. 418 4. 781 1.00 64. 55 6 c ATOM 178 ND1 HIS A 22 25..477 61..778 5,.724 1..00 67..21 7 N ATOM 179 CD2 HIS A 22 27. .442 62, .619 5 .340 1. .00 65 .40 6 C ATOM 180 CE1 HIS A 22 26, .184 61 .588 6 .840 1 .00 68 .44 6 C ATOM 181 NE2 HIS A 22 27. .388 62, .098 6 .620 1. .00 67. .27 7 N ATOM 182 N LEU A 23 26. .460 59 .352 3, .424 1, .00 54, .28 .7 N ATOM 183 CA ' LEU A 23 27. .606 58, .477 3, .365 1, ,00 51, .08 6 C ATOM 184 - C LEU A 23 27. .502 57, .730 2. .053 1. .00 50. .64 6 C ATOM 185 O LEU A 23 28, .485 57 .104 1, .620 1, .00 55, .30 8 O ATOM 186 CB LEU A 23 27. .656 57, .566 4, .586 1, .00 50, .86 6 C ATOM 187 CG LEU A 23 28. .116 58. .228 5. ,867 1. .00 48. .97 6 C ATOM 188 CD1 LEU A 23 27, .806 57. .396 7, .080 1, .00 49, .29 6 C ATOM 189 CD2 LEU A 23 29. .624 58. .488 5, .764 1. .00 51. .85 6 C ATOM 190 N GLY A 24 26, .338 57, .804 1, .443 1, .00 47, .10 7 N ATOM 191 CA GLY A 24 26. .130 57, .152 0, .164 1, ,00 49, ,42 6 C ATOM 192 C GLY A 24 25, .393 55, .820 0, .294 1, .00 48, .86 6 C ATOM 193 O GL.Y A 24 24, .814 55 .434 1, .316 1, .00 48, .17 • 8 O ATOM 194 N LYS A 25 25, .447 55, .071 -0, .811 1. .00 49. .55 7 N ATOM 195 CA LYS A 25 24. .755 53, .757 -0, .780 1, .00 50, .51 6 C ATOM 196 C LYS A 25 25. .776 52. .638 -0. ,834 1. .00 46. .78 6 C ATOM 197 O LYS A 25 26, .871 52, .803 -1, .377 1, ,00 48, .22 8 O ATOM 198 CB LYS A 25 23, .841 53, .546 -2. .007 1. .00 55. .99 6 C ATOM 199 CG LYS A 25 22, .786 52, .855 -1. ,747 0. .00 25. .00 6 C ATOM 200 CD LYS A 25 22, .261 52. .228 -3. .001 0. .00 25. ,00 6 c ATOM 201 CE LYS A 25 20 .808 52 .581 -3, .183 0, .00 25, .00 6. c ATOM 202 NZ LYS A 25 20, .345 52, .281 -4. .556 0, ,00 25. .00 7 N ATOM 203 N PRO A 26 25, .395 51, .533 -0. .210 1. .00 42. ,68 7 N ATOM 204 CA PRO A 26 26, .320 50, .416 -0, .166 1, .00 39, ,07 6 G ATOM 205 C .PRO A 26 26, .345 49. .728 -1, .500 1, .00 37, .59 6 C ATOM 206 O PRO A 26 25, .274 49. .603 -2, .053 1, .00 39. .43 8 O ATOM 207 CB PRO A 26 25. ,588 49. .529 0. ,799 1. .00 39. ,98 6 C ATOM 208 CG PRO A 26 24. .547 50. .256 1. .531 1. ,00 37. .68 6 C ATOM 209 CD PRO A 26 24. .158 51, .252 0. ,517 1. ,00 40, ,06 6 C ATOM 210 N ASP A 27 27. .420 49, .247 -2. ,009 1. .00 35. .64 7 N ATOM 211 CA ASP A 27 27. ,545 48. ,466 -3. .201 1. .00 37. ,19 • 6 C ATOM 212 C ■ ASP A 27 27. .456 47, ,022 -2. ,677 1. ,00 38. .07 6 C ATOM 213 O ASP A 27 28, .207 46, .505 -1. ,869 1, ,00 39. ,12 8 O ATOM 214 CB ASP A 27 28. .864 48. .815 -3. ,935 1. ,00 39. ,81 6 C ATOM 215 CG ASP A 27 29. ,506 47. ,686 -4. 668 1. ,00 45. 42 6 C ATOM 216 OD1 ASP A 27 28. .889 46. .758 -5. ,224 1, ,00 44. ,60 8 O ATOM 217 OD2 ASP A 27 30. .776 47. .651 -4. ,731 1. ,00 51. ,68 8 O ATOM 218 N TYR A 28 26. .500 46. .248 -3. ,116 1, .00 •38. ,37 7 N ATOM 219 CA TYR A 28 26. ,290 44, .874 -2.. ,769 1. ,00 39, ,05 6 C ATOM 220 C TYR A 28 27. ,506 43. ,992 -2. 995 1. ,00 39. 20 6- C ATOM 221 O TYR A 28 27. .885 43, .196 -2. .109 1, ,00 39. ,63 8 O ATOM 222 CB TYR A 28 25, .161 44. .248 -3. .554 1, ,00 37. ,78 ' 6 C ATOM 223 CG TYR A 28 24. .883 42, .820 -3. ,190 r. ,00 43, ,82 6 C ATOM 224 CD1 TYR A 28 24. .630 42, ,441 -1. 848 1. .00 43. 26 • 6 C ATOM 225 CD2 TYR A 28 24, , ' 855 41 ' , .814 -4. ,145 1. ,00 43. ,70 6 C ATOM 226 CE1 TYR A 28 24. .370 41, .150 -1. ,494 1. ,00 43. ,70 6 C ATOM 227 CE2 TYR A 28 24, ,593 40, .497 -3. .794 1. ,00 45. ,14 6 c ATOM 228 CZ TYR A 28 24. ,353 40. ,176 -2. 475 1. .00 46. 75 6 c ATOM 229 OH TYR A 28 24, .088 38, .852 -2. ,127 1, .00 49. ,65 8 0 ATOM 230 ' N • ALA A 29 28, ,118 44. .137 -4. ,154 1. ,00 38. ,45 7 N ATOM 231 CA ALA A 29 29: ;293 43. .320 -4. .471 1. .00 36. ,75 6 C ATOM 232 C ALA A 29 30. ,397 43, .636 -3. ,484 1. ,00 37. ,07 6 c ATOM 233 O ALA A 29 30. .906 42. .611 -3. ,013 1. ,00 40. 68 8 0 ATOM 234 CB ALA A 29 29, .675 43, .419 -5. ,951 ' 1. .00 35, ,51 6 c ' ATOM 235 N LYS A 30 30. .724 .44. .873 -3. 132 1. .00 36. 07 7 N ATOM 236 CA LYS A 30 31, ,769 45, ,125 -2. ,179 1. ,00 35. ,27 6 C ATOM 237 C LYS A 30 31, .412 44. .610 -0. ,791 1, ,00 35. 07 6 C ATOM 238 O LYS A 30 32. .260 44, .103 -0, ,018 1. .00 36. ,78 8 O ATOM 239 CB LYS A 30 32.210 46.627 -2.194 1.00 33.83 6 C ATOM 240 CG LYS A 30 33 .512 46 .994 -1 .388 0.00 25.00 6 C ATOM 241 CD LYS A 30 33 .478 48 .478 -1 .025 0.00 25.00 6 C ATOM 242 CE LYS A 30 34 .867 49 .107 -1 .015 0.00 25.00 6 C ATOM 243 NZ LYS A 30 34 .812 50 .554 -0 .646 0.00 25.00 7 N ATOM 244 N ALA A 31 30 .151 44 .794 -0 .461 1.00 31.95 7 N ATOM 245 CA ALA A 31 29 .601 44 .424 0 .839 1.00 31.96 ■ 6 C ATOM 246 C ALA A 31 29 .650 42 .892 0 .961 1.00 31.51 6 C ATOM 247 O ALA A 31 29 .888 42 .490 2 .085 ■ 1.00 31.06 8 0 ATOM 248 CB ALA A 31 28 .214 44 .966 1 .100 1.00 27.97 6 c ATOM 249 N LEU A 32 29 .459 42 .206 -0 .135 1.00 32.78 7 N ATOM 250 CA LEU A 32 29 .569 40 .723 -0 .129 1.00 33.84 6 C ATOM 251 C LEU A 32 31 .019 40 .336 0 .193 1.00 30.39 6 C ATOM 252 O LEU A 32 31 .167 39 .560 1 .144 1.00 28.93 • 8 O ATOM 253 CB LEU A 32 28 .998 40 .056 -1 .364 1.00 32.99 6 C ATOM 254 CG LEU A 32 28 .619 38 .587 -1. .260 1.00 35.14 6 C ATOM 255 CD1 LEU A 32 27 .326 38 .356 -0 .487 1.00 32.70 6 C ATOM 256 CD2 LEU A 32 28 .525 37 .877 -2. .598 1.00 32.76 6 c ATOM 257 N GLU A 33 32 .027 40 .967 -0. .413 1.00 29.36 7 N ATOM 258 CA GLU A 33 33, .427 40, .684 -0, .066 1.00 27.36 6 C ATOM 259 C GLU A 33 ' 33. .765 41 .061 1 .353 1.00 26.68 6 C ATOM 260 O GLU A 33 34. .516 40. .325 2, .076 1.00 28.43 8 O ATOM 261 CB GLU A 33 34, .342 41, .482 -1. .022 1.00 30.91 6 C ATOM 262 CG GLU A 33 34 .295 41 .095 -2 .505 1.00 36.30 6 C ATOM 263 CD GLU A 33 34 .571 39 .589 -2 .719 1.00 39.53 6 C ATOM 264 OE1 GLU A 33 35 .544 39 .077 -2 .093 ' 1.00 ' 41.03 8 ' O ATOM 265 OE2 GLU A 33 33 .855 38. .898 -3, .482 1.00 38.49 8 0 ATOM 266 N GLN A 34 - 33, .222 42. .195 1, .834 1.00 24.37 7 N ATOM 267 CA GLN A 34 33, .634 42. .548 3, .212 1.00 24.50 6 C ATOM 268 C GLN A 34 33. .089 41. .5,78 4, ,208 1.00 22.24 6 C ATOM 269 O GLN A 34 • 33. .615 41. ,228 5. ,187 1.00 20..90 8- O ATOM 270 CB GLN A 34 33. .231 43. ,990 3. ,516 1.00 29.92 6 C ATOM 271 CG GLN A 34 33, .547 44. .925 2. ,344 1.00 31.30 6 C ATOM 272 CD GLN A 34 33. .268 46. ,357 2. .828 1.00 34.98 6 C ATOM 273 OE1 GLN A 34 32. .247 46. ,581 3. ,474 1.00 31.81 8 O ATOM 274 NE2 GLN A 34 34. .210 47, .253 2, .482 1.00 38.64 7 N ATOM 275 N HIS A 35 31, .892 41, .017 3, .975 1.00 26.42 7 . N ATOM 276 CA HIS A 35 ' 31. .321 40. .014 4. ,886 1.00 24.26 6 C ATOM 277 C HIS A 35 .32. ,137 38. ,700 4. ,891 1.00 24.90 6 C ATOM 278 O HIS A 35 32. ,294 38. .019 5. ,940 1.00 26.43 8 • O ATOM 279 CB HIS A 35 29, ,935 39. ,705 4. ,474 1.00 19.66 6 C ATOM 280 CG HIS A 35 29. ,174 38. ,939 5. 525 1.00 19.66 6 C ATOM 281 ND1 HIS A- 35 28. ,586 39. 491 6. 663 1.00 23.22 7 N ATOM -282 CD2 HIS A 35 28. ,907 37. ,656 5. 590 1.00 16.13 6 C ATOM 283 CE1 HIS A 35 27. ,999 38. 556 7. 362 1.00 19.13 6 . c ATOM 284 NE2 HIS A 35 28. ,210 37. 408 6. 669 1.00 19.06 7 N ATOM 285 N ASN A 36 32. 619 38. .387 3. .706 1.00 22.39 7 N ATOM 286 CA ASN A 36 33. .459 37 ' . 246 3. 425 1.00 25.00 6 C ' ATOM 287 C ASN A 36 34. ,767 37. ,520 4. 147 1.00 25.39 6 C ATOM 288 O ASN A 36 35. ,217 36. 692 4. 941 1.00 23.90 8 O ATOM 289 CB ASN A 36 33, ,509 36. 969 1. 903 1.00 30.86 6 C ATOM 290 CG ASN A 36 34, ,376 35. 698 1. 802 1.00 36.31 6 C ATOM 291 OD1 ASN A 36 33. 942 34. 697 2. 429- 1.00 42.74 8 O ATOM 292 ND2 ASN A 36 35. 487 35. 636 1. 128 1.00 34.95 7 N ATOM 293 -N ALA A. 37 35. 340 38. 726 4. 082 1.00 27.26 7 N ATOM 294 CA ALA A 37 36. 576 38. 991 4. 893 1.00 27.51 6 C ATOM 295 C ALA A 37 36. 270 38. 906 6. 365 1.00 26.90 6 C ATOM 296 O ALA A 37 37. 158 38. 436 7. 137 1.00 31.57 8 O ATOM- 297 CB ALA A 37 37. 315 ' 40. 313 4. 538 1.00 20.67 6 C ATOM 298 N TYR A 38 35. 037 39. 243 6. 763 1.00 25.18 7 N ATOM 299 CA TYR A 38 34. 700 39. 165 8. 192 1.00 24.23 6 C ATOM 300 C TYR A 38 34.626 37.717 8.671 1.00 25.05 6 C ATOM 301 O TYR A 38 34 .994 37 .434 9.818 1.00 24 .85 " 8 O ATOM 302 CB TYR A 38 33 .301 39 .805 8.345 1.00 21 .85 6 C ATOM 303 CG TYR A 38 32 .635 39 .904 9.700 1.00 21 .49 6 C ATOM 304 GDI TYR A 38 33 .161 40 .779 10.718 1.00 22 .78 .6 C ATOM 305 CD2 TYR A 38 31 .530 39 .185 10.007 1.00 19 .03 6 C ATOM 306 CE1 TYR A 38 32 .521 40 .850 11.953 1.00 22 .09 6 C ATOM 307 CE2 TYR A 38 30 .895 39 .272 11.274 1.00 22 .37 6 c ATOM • 308 CZ TYR A 38 31 .435 40 .139 12.245 1.00 19 .79 6 c ATOM 309 OH TYR A 38 30 .794 ' 40 .198 13.459 1.00 24 .81 8 0 ATOM 3.10 N ILE A 39 34 .010 36 .817 7.874 1.00 24 .91 7 N ATOM 311 CA ILE A 39 33 .890 35 .378 8.217 1.00 24 .75 6 c ATOM 312- C ILE A 39 35 .299 34 .824 8.290 1.00 26 .52 6 C ATOM 313 O ILE A 39 35 .680 ■ 34 .219 9.311 1.00 27 .63 8 O ATOM 314 CB ILE A 39 32 .953 34 .577 7.319 1.00 25 .52 6 C ATOM 315 CGI ILE A 39 31 .526 35 .142 7.344 1.00 20 .50 6 C ATOM 316 CG2 ILE A 39 32 .852 33 .062 7.550 1.00 23 .99 6 C ATOM 317 CD1 ILE A 39 30 .963 35 .229 8.795 1.00 18 .38 6 c ATOM 318 N ARG A 40 36 .182 35 .113 7.346 1.00 26 .60 7 N ATOM 319 CA ARG A 40 37 .585 34 .640 7.440 1.00 25 .37 6 C ATOM 320 C ARG A 40 38 .293 35 .124 8.655 1.00 29 .74 6 C ATOM 321 O ARG A 40 39 .078 3 .325 9.252 1.00 3 .08 8 O ATOM 322 CB ARG A 40 38 .383 35 .051 6.188 1.00 22 .95 6 c ATOM 323 CG ARG A 40 37 .635 3 .265 5.029 1.00 22, .33 6 c • ATOM 324 CD ARG A 40 38, .201 34, .598 3.648 1.00 22, .04 6 c ATOM 325 NE ARG A 40 39 .322 33 .696 3.499 1.00 24 .22 7 N ATOM 326 CZ ARG A 40 40 .161 33 .452 2.557 1.00 28, .66 6 c ATOM 327 NH1 ARG A 40 39 .921 34. .235 1.476 1.00 35, .84 7 N ATOM 328 NH2 ARG A 40 41, .144 32, .532 2.656 1.00 28. ,13 7 N ATOM 329 N ALA A 41 • 38. .066 36. .414 9.057 1.00 28. ,.06 7 N ATOM 330 CA ALA A 41 38. ,789 36. ,730 10.332 1.00 24. .37 6 C ATOM 331 C ALA A 41 38. ,211 35. .884 11.419 1.00 27. ,29 6 C ATOM 332 O ALA A 41 38, .981 35, .368 12.235 1.00 34. .11 8 O ATOM 333 CB ALA A 41 38. ,661 38. ,192 10.589 1.00 21. .19 6 . C ATOM 334 N LEU A 42 ' 36. ,880 35. ,712 11.486 1.00 25. ,91 7 N ATOM 335 CA LEU A 42 36. ,330 34. ,941 12.577 1.00 26. 34 6 C ATOM 336 C LEU A 42 36. ,847 33. ,531 12.559 1.00 29. 26 6 C ATOM 337 O LEU A 42 37. .177 32. .927 13.577 1.00 34. ,17 8 0 ATOM 338 CB LEU A 42 34. ,804 35. ,006 12.455 1.00 24. 15 6 C ATOM 339 CG LEU A 42 34. .234 36. .390 12.903 1.00 25. ,87 6 c ATOM 340 CD1 LEU A 42 32. 756 36. 586 12.400 1.00 24. 15 6 c ATOM 341 CD2 LEU A 42 34. 408 36. 600 14.359 1.00 18. 61 6 c ATOM ■ 342 N GLN A 43 37. 005 32. 834 11.476 1.00 30. 44 7 N ATOM 343 CA GLN A 43 37. 531 31. 513 11.284 1.00 32. 34 6 C ATOM 344 C GLN A 43 38. ,868 31. ,338 11.982 1.00 34. 70 6 C ATOM 345 .0 GLN A 43 39. 280 30. 241 12.267 1.00 37. 30 8 0 ATOM 346 CB GLN A 43 - 37. 685 31. 240 9.777 1.00 30. 76 6 C. ATOM 347 CG GLN A 43 36. 423 30 ' . 706 9.193 ' 1.00 30. 88 6 c ATOM 348 CD GLN A 43 ■ 36. 618 30. 485 7.705 1.00 32. 57 6 c ATOM 349 OE1 GLN A 43 36. 771 29. 314 7.310 1.00 35. 75 8 0 ATOM 350 NE2 GLN A 43 36. 621 31. 494 6.878 1.00 28. 89 7 N ATOM 351 N THR A . 44 39. 625 32. 363 12.270 1.00 35. 85 7 N ATOM 352 CA ' THR A 44 40. 874 32. 334 13.040 1.00 36. 77 6 C ATOM 353 C THR A- 44 40. 596 32. 444 14.503 1.00 36. 18 6 C ATOM 354 O THR A 44 41. 463 ' 32. 091 15.258 1.00 39. 71 8 O ATOM 355 CB THR A 44 41. 475 33. 594 12.385 1.00 38. 69 6 C ATOM 356 OG1 THR A 44 42. 219 33. 125 11.253 1.00 38. 83 8 0 ATOM 357 CG2 THR A 4 42. 108 34. 565 13.297 1.00 41. 01 6 c ATOM 358 N CYS A 45 39. 486 32. 826 15.098 1.00 34. 29 7 N ATOM 359 CA CYS A 45 39. 262 ' 32. 976 16.528 1.00 34. 07 6 c ATOM 360 C CYS A 45 38. 895 31. 770 17.346 1.00 35. 08 6 c ATOM 361 O CYS A 45 38,.372 31,.905 18.469 1.00 37.73 8 0 ATOM 362 CB CYS A 45 38 .172 34 .104 16 .630 1 .00 29 .98 6 c ATOM 363 SG CYS A 45 38, .733 35, .572 15 .712 1 .00 35 .91 16 S ATOM 364 N ASP A 46 39, .156 30, .549 16 .939 1' .00 34 .71 7 N ATOM 365 CA ASP A 46 38 .871 29, .321 17 .661 1 .00 35 .36 6 C ATOM 366 C ASP A 46 37, .423 29, .288 18 .109 1 .00 33 .28 6 C ATOM 367 O ASP A 46 37, .030 29, .221 19 .240 1 .00 30 .74 8 O ATOM 368 CB ASP A 46 39 .725 29 .147 18 .913 1 .00 43 .62 6 C ATOM 369 CG ASP A 46 41, .210 29, .107 18, .615 1 .00 53 .54 6 C ATOM 370 OD1 ASP A 46 41, .667 27, .985 18 .258 1 .00 57 .92 8 O ATOM 371 OD2 ASP A 46 41, .909 30, .164 18 .731 1. .00 57 .53 8 o ATOM 372 N VAL A 47 36, .513 29, .370 17, .184 1 .00 32, .70 ' 7 N ATOM 373 CA VAL A 47 35, .070 29, .383 17, .424 1 .00 29. .52 6 C ATOM 3 4 C VAL A 47 34, .492 28. .729 16 .239 1 .00 28 .10 6 C ATOM 375 O VAL A 47 35. .166 28. ,715 15, .152 1. .00 29, .55 8 O ATOM 376 CB VAL A 47 34. .833 30. .912 ■17, .555 1 .00 33, .41 6 C ATOM 377 CGI VAL A 47 34, .380 31. .531 16, .2.54 1, .00 29, .25 6 C ATOM 378 CG2 VAL A 47 34, .007 31, .245 18, .801 1, .00 33, .11 6 C ATOM 379 N ASP A 48. 33, .343 28. .104 16, .395 1, .00 27. .21 7 N ATOM 380 CA ASP A 48 32, .774 27, .580 15, .137 1. .00 28, .52 6 • C ATOM 381 C ASP A 48 31. .769 28, .656 ' 14, .700 1. .00 26. .68 6 C ATOM 382 O ASP A 48 31, .218 29, .457 15, .487 1, .00 25, .75 8 O ATOM 383 ' CB ASP A 48 32, .223 26, .210 15 .169 1 .00 33, .17 6 c ATOM ■ 384 CG ASP A 48 31. .303 25. .949 16, .287 1, .00 37. .40 6 c ATOM 385 OD1 ASP A 48 30, .661 26, .975 16, .604 1 .00 39, .92 8 0 ATOM 386 OD2 ASP A 48 31. .210 24. .818 16, .825 1, .00 41. .59 8 0 ATOM 387 N ILE A 49 31, .421 28. .693 13. .459 1, .00 24. .70 7 N ATOM 388 CA ILE A 49 30, .563 29. .648 12. .852 1, .00 25. .72 6 C ATOM 389 C ILE A 49 29. .294 29, ,073 12, .308- 1 .00 30-, .12 6 C ATOM 390 O ILE A 49 29. .420 28, ,144 11, ,491 1. .00 35. ,34 8 O ATOM 391 CB ILE A 49 31. .383 30, .196 11, .675 1, .00 25, .39 6 C ATOM 392 CGI ILE A 49 32. .551 31. .010 12. ,334 1. .00 21. .19 6 C ATOM 393 CG2 ILE A 49 30. .593 31. ,039 10. ,713 1, .00 25. .74 6 C ATOM 394 GDI ILE A 49 33. .519 31, ,605 11. ,415 1. .00 20. ,51 6 c ATOM 395 N THR A 50 28. .102 29. ,590 -12. .616 1 ' ,roo 27. .07 7 N ATOM 396 CA THR A 50 26. .904 29. ,167 11. ,983 1, ,00 23. ,13 6 C ATOM 397 C THR A 50 26, .636 30, ,260 10. .921 1. ,00 25. ,15 6 C ATOM 398 O THR A 50 26, ,468 31. ,382 11. .444 1. ,00 28. ,58 8 O ATOM 399 CB THR A 50 25, ,876 29. ,007 13. 008 1. ,00 21. 68 6 C ATOM 400 OG1 THR A 50 26. .374 " 27. ,840 13. ,652 ' 1. ,00 27. ,10 8 0 ATOM 401 CG2 THR A 50 24. ,512 28. ,613 12. 406 1. ,00 22. .71 6 - C ATOM 402 N LEU A 51 26. .758 30. ,078 9. 646 1. ,00 20. .93 7 N ATOM 403 CA LEU A 51 26. .555 31, ,164 8. ,633 1. ,00 20. ,68 6 C ATOM 404 ■ C LEU A 51 25. ,206 30. .985 7. 990 1. ,00 23. .53 6 c ATOM 405 O LEU A 51 24. ,907 29. ,912 7. 333 1. ,00 26. 60 8 0 ATOM 406 CB LEU A 51 27. ,515 31. ,105 7. 466 1. ,00 18. 66 6 c ATOM 407 CG LEU A 51 27, .808 32. ,163 6. 448 1. ,00 23. 76 6 c ATOM 408 CD1 LEU A 51 27, .634 33. ;633 6. 985 1. ,00 25. 13 6 c ATOM 409 CD2 LEU A 51 29, ,272 32. ,111 5. .953 1. .00 18. ,53 6 c ATOM 410 N LEU A 52 24. ,264 31. 863 8. 260 1. 00 22. 18 7 N ATOM 411 CA LEU A 52 22, ,944 31. 643 7. 687 1. .00 20-. 34 6 C ATOM 412 C LEU A 52 22. ,813 32. ,323 6. 304 1. ,00 18. ,64 6 C ATOM 413 0 . ■ LEU A 52 23. ,523 33. 209 5. 981 1. 00 16. 87 8 O ATOM ■ 414 CB LEU A. 52 21, .913 32, ,266 8. .646 1. ,00 22. ,30 6 c ATOM 415 CG LEU A 52 21. ,869 31. 698 10. 069 1. ,00 25. 14 6 c ATOM 416 GDI LEU A 52 20. ,888 32. , ' 486 10. 925 1. ,00 20. ,85 6 c ATOM 417 CD2 LEU A 52 21. .698 30. 196 10. 156 1. 00 19. 64 6 c ATOM 418 N PRO A 53 21, .862 31. ,869 5, 487 1. ,00 19. ,01 7 N ATOM 419 CA PRO A 53 21, ,541 32. 307 4. 134 ' 1. 00 21. 41 6 C ATOM 420 C PRO A 53 20, .860 33. ,676 4. 099 1. ,00 24. ,30 6 C ATOM 421 O PRO A •53 20, ,235 34. 099 5. 066 1. 00 24. 47 8 O ATOM 422 CB PRO A 53 20.596 31.209 3.559 1.00 16.73 6 C ATOM 423 CG. PRO A 53 19 .898 30 .852 4 .922 1.00 18.80 6 C ATOM 424 CD PRO A . 53 20. .980 30 .688 5 .927 1.00 14.11 6 C ATOM 425 N PRO A ' 54 21 .057 34 .395 2 .991 1.00 27.10 7 N ATOM 426 CA PRO A 54 20. .486 35 .714 2 .805 1.00 28-.32 6 C ATOM 427 C PRO A 54 18 .958 35 .494 2 .774 1.00 33.08 6 C ATOM 428 O PRO A 54 18 .427 34 .440 2 .454 1.00 33.86 8 O ATOM 429 CB PRO A 54 20 .982 36 .164 1 .477 1.00 26.61 6 C ATOM 430 CG PRO A 54 21 .568 34 .994 0 .750 1.00 24.83 6 C ATOM 431 CD PRO A 54 21 .743 ' 33 .904 1. .752 1.00 26.69 6 C ATOM 432 N ASP A 55 18 .268 36 .487 3 .265 1.00 35.16 7 N ATOM 433 CA ASP A 55 16, .823 36, .534 3. .287 1.00 34.29 6 C ATOM 434 C ASP A 55 16, .507 37, .924 2, .692 1.00 36.97 6 C ATOM 435 O ASP A 55 16 .690 38 .977 3. .307 1.00 38.84 8 O ATOM ' 436 CB ASP A 55 16. .302 36 .328 4 .666 1.00 30.78 6 C ATOM 437 CG ASP A 55 14, .861 35 .884 4, .624 1.00 31.36 6 C ATOM • 438 OD1 ASP A 55 14 .110 36 .272 3. .724 1.00 27.22 8 O ATOM 439 OD2 ASP A 55 14. .436 35, .104 5. .533 1.00 35.57 8 O ATOM 440 N GLU A 56 16 .123 37 .953 1 .432 1.00 36.78 7 N ATOM 441 CA GLU A 56 15. .791 39, .112 0, .617 1.00 37.87 6 C ATOM 442 C GLU A 56 14 .580 39, .853 1. .197 1.00 38.05 6 C ATOM 443 O GLU A 56 14, .430 41, .039 0. .910 1.00 37.55 8 O ATOM 444 CB GLU A 56 15, .498 38, .777 -0. .858 1.00 35.35 6 C ATOM 445 CG GLU A 56 16 .795 38 .184 -1 .450 1.00 35.32 6 C ATOM 446 CD GLU A 56 17, .818 39. .281 -1, .544 1.00 38.08 6 C ATOM 447 OE1 GLU A 56 17, .541 40, .468 -1, .313 1.00 38.12 8 O ATOM 448 OE2 GLU A 56 18, .990 39, .066 -1, .860 1.00 43.09 8 O ATOM 449 N ARG A 57 13, .843 39, .171 2, .045 1.00 35.05 7 N ATOM 450 CA ARG A 57 12, .724 39, .843 2, .681 1.00 35.86 6 C ATOM 451 C ARG A 57 13, ,212 40. .7-97 3. .768 1.00 36.89 6 C ATOM 452 O ARG A 57 12. .455 41, .624 4. .194 1.00 33.57 8 ■ 0 ATOM 453 CB ARG A 57 11. .888 38. ,743 3. .347 1.00 35.40 6 c ATOM 454 CG ARG A 57 10, .912 38, .015 2, .428 1.00 35.86 6 c ATOM 455 CD ARG A 57 10. .280 36, .867 3. .207 1.00 41.11 6 c ATOM 456 NE ARG A " " 57 11, .270 36. .029 3. .844 1.00 43.62 7 N ATOM 457 CZ ARG A 57 10. .953 35. .017 4. ,665 1.00 46.02 6 c ATOM 458 NH1 ARG A 57 9. .696 34, ,728 4. ,934 1.00 42.67 7 N ATOM 459 NH2 ARG A 57 11. .938 34, .273 5. .231 1.00 43.71 7 N ATOM 460 N PHE A 58 14. ,438 40. ,663 4. ,314 1.00 35.40 7 ' N ATOM 461 CA PHE A 58 15. .008 41. ,468 5. .356 1.00 31.50 6 C ATOM 462 C PHE A 58 16. .387 42. .033 5, .068 1.00 32.43 6 C ATOM 463 O PHE A 58 17. .450 41. ,521 5. ,488 1.00 33.72 8 O ATOM 464 CB PHE A 58 15, .074 40. ,705 6. .680 1.00 31.73 6 '■ C ATOM 465 CG PHE A 58 13. ,701 , 40. ,229 7. ,072 1.00 33.55 6 C ATOM 466 CD1 PHE A ' 58 13. .300 38. ,954 6. .778 1.00 36.83 6 C ATOM 467 CD2 PHE A 58 12. ,814 41. ,074 7. ,728 1.00 33.80 6 C ATOM 468 CE1 PHE A 58 12. ,020 38. ,538 7. 155 1.00 38.15 6 c ATOM 469 CE2 PHE A " 58 11. ,565 40. , ' 597 8. ,067 1.00 35.99 6 c ATOM 470 CZ PHE A 58 11. ,107 39, ,324 7. ,801 1.00 32.90 6 c ATOM 471 N PRO A 59 16. ,410 43. .217 4. ,454 1.00 31.86 7 N ATOM 472 CA PRO A 59 17. ,581 43. 912 4. 059 1.00 30.00 6 C ATOM 473 C PRO A 59 18. ,589 44. 017 5. 140 1.00 32.05 6 C ATOM 474 O' .PRO A 59 19. ,772 44. .013 4. ,860 1.00 33.61 8 , O ATOM 475 CB PRO A . 59 17. ,044 45. 334 3. ,666 1.00 30.27 6 C- ATOM ' 476 CG PRO A 59 15, ,663 45. 043 3. 097 1.00 29.24 6 C ATOM 477 CD PRO A 59 15. ,138 43. 887 3. 908 1.00 32.56 6 C ATOM 478 N ASP A 60 18. .215 44. .221 6. ,378 1.00 31.89 7 N ATOM 479 CA ASP A 60 19. .159 44. 372 7. 490 1.00 32.41 6 C ATOM 480 C ASP A 60 19. ,373 43. 034 8. 180 1.00 30.02 6 C ATOM 481 0 ASP A 60 20. 027 43. 030 9. 222 1.00 28.97 8 0 ATOM 482 CB ASP A 60 18. 473 45. 419 8. 447 1.00 33.85 6 C ATOM 483 CG ASP A 60 18.483 46.809 7.842 1.00 37.89 6 C ATOM 484 OD1 ASP A 60 19 .584 47 .413 7 .628 1 .00 40 .07 8 O ATOM 485 OD2 ASP A 60 17 .477 47 .484 7 .504 1 .00- 37 .08 8 O ATOM 486 ■ N SER A 61 18 .901 41 .884 7 .663 1 .00 27 .23 7 N ATOM 487 CA SER A 61 19 .108 40 .675 8 .457 1 .00 28 .36 6 C ATOM 488 C SER A 61 20 .571 40 .358 8 .543 1 .00 25 .73 6 C ATOM 489 O SER A 61 20 .863 39 .528 9 .372 1 .00 26 .88 ' 8 0 ATOM 490 CB SER A 61 18 .446 39 .326 8 .002 1 .00 30 .66 6 • C ATOM 491 OG SER A 61 18 .346 39 .409 6 .583 1 .00 31 .07 8 0 ATOM 492 N VAL A 62 21 .477 40 .957 7 .796 1 .00 25 .63 7 N ATOM 493 CA VAL A 62 22 .886 40 .693 7 .991 1 .00 24 .54 6 c ATOM 494 C VAL A 62 23 .212 41 .164 9 .417 1 .00 26 .53 6 ' c ATOM 495 O VAL A 62 24 .216 40 .638 9 .917 1 .00 27- .73 8 - 0 ATOM 496 CB VAL A 62 23 .692 41, .490 6 .961 1 .00 24 .13 6 c ATOM 497 CGI VAL A 62 23. .411 43, ,008 7, .227 1, .00 23, .39 6 c ATOM 498 CG2 VAL A 62 25 .158 41, .192 7, .192 1, .00 21 .16 6 c ATOM 499 N PHE A 63 22 .471 42, .087 10. .044 1, . 00 25. .99 7 N ATOM 500 CA PHE A 63 22 .816 42, .475 11 .383 1, .00 29 .11 6 C ATOM 501 C PHE A 63 22 .198 41, .513 12. .409 1, .00 30 .42 6 C ATOM 502 O PHE A 63 21 .319 42, .034 13, .102 1, .00 31, .13 8 O ATOM 503 CB PHE A 63 ■ 22 .402 43, ..933 11 .718 1, .00 27 .93 6 c ATOM 504 CG PHE A 63 23. .108 44, .821 10, .712 1, .00 30, .27 6 c ATOM 505 CDl .PHE A 63 22 .362 45, .629 9, .886 1, .00 30 .49 6 c ATOM 506 CD2 PHE A 63 24. .484 44. .846 10, ,591 1. .00 29, .21 6 c ATOM 507- CE1 PHE A 63 23, .043 46. .425 8. .973 1. .00 32, .10 6 c ATOM 508 CE2 PHE A ' 63 25, .101 45. .646 9, .687 1, .00 28, .92 6 c ATOM 509 CZ PHE A 63 24 .399 ' 46. .453 8, .857 1. .00 30, .37 6 c ATOM ■ 510 N- VAL A 64 22 .737 40, .319 12, .539 1, .00 27, .88 7 N ATOM 511 CA VAL A 64 22, .146 39. .359 13, .474 1. .00 28. .28 6 c ATOM 512 C VAL A 64 22 .247 39, .792 14, .898 1, .00 27 .87 6 c ATOM 513 O VAL A 64 21 .486 39. .271 15. ,721 1, .00 27, .81 8 O ATOM 514 CB VAL A 64 22, .650. 37. .897 13. ,246 ' 1. ,00 27. ,99 6 c ATOM- 515 CGI VAL A 64 22, .457 37. .544 11. ,757 1. .00 28. .02 6 c ATOM 516 CG2 VAL A 64 24. ,151 37. ,702 13. ,542 1. ,00 23. ,97 6 c ATOM 517 N GLU A 65 23, .149 40. ,688 15. ,298 1. .00 28. ,38 7- N ATOM 518 CA GLU A 65 23, .162 41. ,104 16. ,702 1. ,00 26. .08 6 C ATOM 519 C GLU A 65 21. ,794 41. ,581 17. ,187 1. ,00 27. ,45 6 C ATOM 520 O GLU A 65 21. ,359 ' 41. ,282 18. ,311 1. ,00 28. ,15 8 O ATOM 521 CB GLU A 65 24. ,117 42. ,274 16. ,802 1. ,00 26. ,92 6 c ATOM 522 CG GLU A 65 24, .126 42. ,976 18. ,166 1. ,00 28. ,58 6 c ATOM 523 CD.- GLU A 65 25. ,444 43. ,678 18. ,345 1. ,00 29. ,06 6 c ATOM 524 OE1 , GLU A 65 25. .436 44. ,798 17. ,749 1. ,00 33. ,68 8 0 ATOM 525 OE2 ' GLU A 65 26. ,445 43. 278 18. 963. 1. 00 32. 32 8 0 ATOM 526 N ASP A 66 20, ,928 42. ,265 16. ,482 1. ,00 27. ,02 7 N ATOM 527 CA ASP A 66 19. .685 42. ,889 16. 884 1. 00 27. 62 6 c ATOM 528 C ASP A 66 18. ,592 42. 019 17. ,391 1. 00 29. 94 6 C ATOM 529 O ASP A 66 18. ,132 42. 178 18. 504 1. 00 32. ,85 8 O ATOM 530 CB ASP A 66 19. ,270 43. ,962 15. .878 1. 00 26. 56 6 C ATOM 531 CG ASP A 66 20. ,317 45. .071 16. 092 1. 00 31. 25 6 c ATOM 532 OD1 ASP A 66 20, ,776 45. 423 17. 242 1. 00 31. 97 8 O ATOM 533 OD2 ASP A 66 20. 701 45. 606 15. 037 1. 00 33. 10 8 0 ATOM 534 N PRO A 67 18. ,252 40. 968 16. 679 1. 00 31. 77 7 N ATOM 535 CA PRO A 67 17. .241 40. 053 17. 099 1. 00 29. 37 6 C ATOM 536 C PRO A. 67 17. ,448 39. 096 18. 233 1. 00 31. 41 6 C ATOM 537 σ 'PRO A 67 16. .420 38. 428 18. 510 1. 00 33. 18 8 O ATOM 538 ' CB PRO A ■ 67 17. 007 39. 275 15. 820 1. 00 29. 86 6 C ATOM 539 CG PRO A 67 18. .124 39. 550 14. 879 1. 00 30. .41 6 c ATOM 540 CD PRO A 67 18. ,796 40. 796 15. 288 1. 00 28. 88 6 c ATOM 541 N VAL A 68 18. ,545 38. 836 18. 945 1. 00 30. 40 7 N ATOM 542 CA VAL A 68 18. 566 3-7. 861 19. 992 1. 00 30. 34 6 C ATOM 543 C VAL A 68 19. 749 38. 300 20. 924 1. 00 32. •47 6 C ATOM 544 O VAL A 68 20.667 38.844 20.297 1.00 31.27 8 O ATOM 545 CB VAL A 68 19 .125 36 .464 19.600 1.00 35.49 6 C ATOM 546 CGI VAL A 68 18 .744 35 .303 20.591 1.00 34.53 6 c ATOM 547 CG2 VAL A ■ 68 18 .825 35 .953 18.206 1.00 32.75 6 c ATOM 548 N LEU A 69 19 .707 38 .056 22.238 1.00 31.41 7 N ATOM 549 CA LEU A 69 20 .848 38 .340 23.076 1.00 31.10 6 c ATOM 550 C LEU A 69 21 .246 36 .867 23.499 1.00 33.71 6 C ATOM 551 O LEU A 69 20 .281 36 .154 23.947 1.00 35.34 8 O ATOM 552 CB LEU A 69 20 .493 ' ' 39 .033 24.357 1.00 30.39 6 C ATOM 553 CG LEU A 69 21 .585 39 .543 25.235 1.00 31.74 6 C ATOM 554 CD1 LEU A 69 22 .129 40 .700 24.478 1.00 34.28 6 C ATOM 555 CD2 LEU A 69 21 .021 40 .087 26.597 1.00 35.48 6 C ATOM 556 N CYS A 70 22 .512 36 .453 23.382 1.00 28.50 7 N ATOM 1 557 CA CYS A 70 22 .892 35 .110 23.763 1.00 31.35 6 C ATOM 558 C CYS A 70 23 .740 35 .209 25.015 1.00 33.80 6 C ATOM 559 O CYS A 70 24 .825 35 .818 25.027 1.00 34.34 • 8 O ATOM 560 CB CYS A 70 23 .669 34 .344 22.642 1.00 30.28 6 C ATOM 561 SG CYS A 70 22 .537 34 .093 21.181 1.00 31.35 16 S ATOM 562 N THR A 71 23 .191 34 .599 26.079 1.00 37.46 7 N ATOM 563 CA THR A 71 23 ..943 34 .709 27.374 1.00 39.71 6 C ATOM 564 C THR A 71 24 .364 33 .291 27.651 1.00 41.48 6 C ATOM 565 O THR A 71 23 .934 32 .399 26.862 1.00 40.94 8 O ATOM 566 CB THR A 71 22 .978 35 .210 28.439 1.00 40.24 6 C ATOM 567 OG1 THR A 71 21- .963 34. .199 28.561 1.00 41.56 8 O ATOM 568 CG2 THR A 71 22 .220 36 .426 27.892 1.00 35.95 6 C ATOM 569 N SER A 72 25 .101 33, .143 28.755 1.00 40.00 7 N ATOM 570 CA SER A 72 25 .581 31, .806 ' 29.099 1.00 36.31 6 ' c ATOM • 571 C SER A 72 24. .528 30. .976 29.745 1.00 39.27 6 c ATOM 572 O SER A 72 24, .862 29, .901 30.231 1.00 42.43 8 0 ATOM 573 CB SER A 72 26, .722 32, .061 30.084 1.00 36.25 .6 c ATOM 574 OG SER A 72 26, .050 32. ,650 31.246 1.00 38.53 8 0 ATOM 575 N ARG A 73-' 23, .269 31. .374 29.815 1.00 41.04 7 N ATOM 576 CA ARG A 73 22, .253 ' 30. .594 30.513 1.00 41.40 6 C ATOM ' 577 C ARG A 73 21. .007 30. ,606 29.636 1.00 41.34 6 C ATOM . 578 O ARG A 73 20. ,221 29. ,603 29.712 1.00 46.04 8 O ATOM 579 CB ARG A 73 21. .886 31. .161 31.891 1.00 42.16 ._6 C ATOM 580 CG ARG A 73 23. .019 31. ,575 32.797 1.00 45.77 6 C ATOM 581 CD ARG A 73 23. ,324 30. 953 34.112 1.00 52.47 6 c ATOM 582 NE ARG A 73 24. ,335 31. 693 34.896 1.00 57.98 7 N ATOM 583 CZ ARG A 73 24. 030 . 32. 484 35.924 1.00 60.40 6 c ATOM 584 NH1 ARG A ' 73 22. .736 32. 598 36.246 1.00 ' 61.61 7 N ATOM 585 NH2 ARG A 73 24. .892 33. 178 36.673 1.00 61.75 7 - N ATOM 586 N CYS A 74 20. 710 31. 598 28.861 1.00 36.56 7 N ATOM 587 CA CYS A 74 19. .480 31. 523 28.068 1.00 36.88 6 c ATOM 588 C CYS A 74 19. 781 32. 340 26.813 1.00 36.05 6 C ATOM 589 O CYS A 74 20. 922 32. 871 26.697 1.00 39.58 8 O ATOM 590 CB CYS A 74 18. 243 32. 088 28.757 1.00 38.40 6 C ATOM 591 SG CYS A 74 18. 228 33. 865 29.190 1.00 44.59 16 S ATOM 592 N ALA A 75 18. 826 32, 448 25.950 1.00 33.14 7 N ATOM 593 CA ALA A 75 18. 936 33. 349 24.802 1.00 34.63 6 C ATOM 594 C ALA A 75 17. 502 34. 003 ' 24.768 1.00 35.44 6 C ATOM 595 O ALA A 75 16. 518 33. 291 24.962 1.00 34.93 8 O ATOM 596 CB ALA A 75 19. 081 32. 821 23.392 1.00 30.52 6 ' C ATOM 597 N ILE A 76 17. 449 35. 303 24.486 1.00 31.88 7 N ATOM 598 CA ■ ■ILE A 76 16. 184 35. 976 24.456 1.00 29.70 6 C ATOM 599 C ILE A ■ 76 15. 913 36. 491 23.063 1.00 31.68 6 C ATOM 600 O ILE A 76 16. 698 37. 327> 22.461 1.00 33.66 8 O ATOM 601 CB ILE A 76 16. 336 37. 135 25.556 1.00 27.80 6 C ATOM 602 CGI ILE A 76 16. 554 36. 637 26.977 1.00 25.83 6 C ATOM 603 CG2 ILE A 76 15. 039 37. 917 25.417 1.00 28.27 6 C ATOM 604 CD1 ILE A 76 18. 051 36. 626 27.434 1.00 26.23 6 C ATOM 605 N ILE A 77 14.858 36.049 22.385 1.00 30.90 7 N ATOM 606 CA ILE A 77 14 .575 36 .590 21 .050 1.00 30 .11 6 C ATOM 607 C ILE A 77 14 .143 38 .023 21 .386 1.00 35 .09 6 C ATOM 608 O ILE A 77 13 .316 38 .193 22 .333 1.00 40 .24 8 O ATOM 609 CB ILE A 77 13. .415 35 .862 20 .399 1.00 31 .67 6 C ATOM 610 CGI ILE A 77 13 .730 34 .348 20 .277 1.00 36 .56 6 C ATOM 611 CG2 ILE A 77 13 .104 36 .323 19 .020 1.00 30 .14 ' 6- C- ATOM 612 CD1 ILE A 77 14 .871 34 .067- 19 .291 1.00 35 .01 6 C ATOM 613 N THR A 78 14 .594 39 .079 20 .731 1.00 34 .47 7 N ATOM 614 CA THR A 78 14 .250 40 .418 21 .124 1.00 34 .03 6 C ATOM 615 C THR A 78 13 .042 ' 40 .818 20 .333 1.00 37 .00 6 C ATOM 616 O THR A 78 12 .410 39 .875 19 .847 1.00 40 .06 8 O ATOM 617 CB THR A 78 15 .445 ' 41 .352 20 .839 1.00 34 .73 6 ' C ATOM 618 OG1 THR A 78 15 .675 41 .361 ■ 19- .426 1.00 32 .31 8 O ATOM 619 CG2 THR A 78 16 .626 40 .878 21 .655 1.00 33 .05 6 C ATOM 620 N ARG A 79 12 .657 42 .037 20 .165 1.00 35 .94 7 N ATOM 621 CA ARG A 79 11 .470 42 .447 19 .415 1.00 35 .29 6 ' C ATOM . 622 C ARG A 79 11 .799 43 .911 18 .998 1.00 36 .78 6 C ATOM 623 O ARG A 79 11 .549 44. .922 19 .678 1.00 35, .76 8 O ATOM 624 CB ARG A 79 10 .239 42, .405 20 .346 1.00 35. .77 6 c ATOM 625 CG ARG A ' 79 9 .019 42 .873 19 .475 1.00 35. .31 6 ■ c ATOM 626 CD ARG A 79 7 .767 42, .511 20, .291 1.00 38, .35 6 c ATOM 627 NE ARG A 79 6 .672 43 .036 19 .491 1.00 40, .63 ' 7 N ATOM 628 CZ ARG A 79 6 .259 44, .297 19 .463 1.00 40, .32 . 6 C ATOM 629 NH1 ARG A 79 6 .881 45, .176 20 .222 1.00 36, .52. 7 N ATOM 630 NH2 ARG A 79 5. .223 44, .527 18, .634 1.00 41, .78 7 N ATOM 631 N PRO A 80 12. .467 44, .008 17, .880 1.00 38. .93 7 N ATOM - 632 CA PRO A 80 13 .033 45, .210 17. .333 1.00 40, .61 6 C ATOM 633 C PRO A 80 12 .051 46, .342 17, .159 1.00 39, .05 6 C ATOM 634 O PRO A 80 10. .957 46, .079 16, .775 1.00 38. .29 8 O ATOM 635 CB PRO A 80 13. .750 44, .827 16. .035 1.00 39. ,62 6 C ATOM 636 CG PRO A 80 13, .892 43. .361 16. .076 1.00 39. ,34 6 C ATOM 637 CD PRO A 80 12. .841 42. .846 16. .997 1.00 42. ,12 6 C ATOM 638 N GLY A 81 12. .531 47, ,519 17. .455 1.00 39. ,77 7 N ATOM ■ 639 CA GLY A 81 11. ,646 48, ,721 17, ,314 1.00 42. ,41 6 C ATOM 640 C GLY A 81 11. ,4.27 48. ,926 15. ,845 1.00 43. 43 6 C ATOM 641 O GLY A 81 10. .312 49. ,167 15. ,466 1.00 45. ,38 8 O ATOM 642 N ALA A 82 • 12. ,470 48. 772 15. ,016 1.00 43. 72 7 N ATOM 643 CA ALA A 82 12. ,173 48. ,956 13. ,580 1.00 44. 48 6 C ATOM ' 644 C ALA A 82 11. ,273 ' 47. ,818 13. ,146 1.00 47. 68 6 c ATOM 645 O ALA A 82 11. ,586 46. 630 13. 236 1.00 47. 18 8 0 ATOM 646- CB ALA A 82 13. ,490 49. ,036 12. ,825 1.00 4.3. 34 6 C ATOM 647 N GLU A 83 10. ,118 48. 087 12. 596 1.00 49. 49 7 N ATOM 648 CA GLU A 83 9. ,143 47. 143 12. 091 1.00 49. 64 6 C ATOM 649 C GLU A 83 9. ,499 46. 477 10. 787 1.00 48. 16 6 C ATOM 650 O GLU A 83 8. 974 45. 518 10. 209 1.00 49. 66 8 O ATOM 651 CB GLU A 83 7. 964 48. 151 12. 044 - 1.00 53. 64 6 C ATOM 652 CG GLU A 83 6. 701 47. 375 11. 869 1.00 59. 06 6 C ATOM 653 CD GLU A .83 5. 460 48. 049 12. 414 1.00 62. 18 6 C ATOM 654 OE1 GLU A 83 5. 534 49. 082 13. 106 1.00 62. 90 8 O ATOM 655 OE2 GLU A .83 4. 448 47. 385 12. 033 1.00 63. 18 8 0 ATOM 656 N SER A 84 10. 562 46. 983 10. 170 1.00 46. 07 7 N ATOM ' 657 CA SER A 84 11. 003 46. 316 8. 922 1.00 44. 81 6 C ATOM 658 C SER A 84 11. 939 45. 178 9. 293 1.00 43. 65 6 C ATOM 659 O " SER A 84 12. 152 44. 366 ' 8. 463 1.00 45. 26 8 O ATOM 660 CB SER A ■ 84 11. 668 47. 313 8. 002 1.00 43. 66 6 C ATOM 661 OG SER A 84 12. 899 47. 794 8. 427 1.00 43. 12 8 O ATOM 662 N ARG A 85 12. 488 45. 127 10. 482 1.00 42. 86 7 N ATOM 663 CA ARG A 85 13. 381 44. 159 11. 014 1.00 40. 83 6 C ATOM 664 C ARG A 85 12. 690 43. 281 12. 071 1.00 42. 90 6 ' C ATOM 665 O ARG A 85 13. 337 42. 399 12. 628 1.00 43. 73 8 0 ATOM 666 CB ARG A 85 14.579 44.866 11.679 1.00 35.86 6 C ATOM 667 CG ARG A 85 15 .290 45 .945 10 .891 1 .00 30 .73 6 c ATOM 668 CD ARG A 85 16 .770 46 .158 11 .316 1 .00 27 .47 6 c ATOM 669 NE ARG A 85 17 .367 44 .829 11 .518 1 .00 27 .90 7 N ATOM 670 CZ ARG A 85 18 .460 44 .602 12 .226 1 .00 28 .75 6 C ATOM 671 NH1 ARG A 85 19 .104 45 .611 12 .811 1 .00 25 .10 7 N ATOM 672 NH2 ARG A 85 18 .878 43 .311 12 .323 1 .00 29 .00 7 N ATOM 673 N ARG A 86 11 .412 43 .441 12 .351 1 .00 42 .27 7 N ATOM 674 CA ARG A ' 86 10 .793 42 .613 13 .391 1 .00 43 .53 6 C ATOM 675 C ARG A 86 10 .651 41 .159 13 .014 1 .00 42 .53 6 C ATOM 676 O ARG A 86 10 .894 40 .317 13 .902 1 .00 41 .77 8 O ATOM 677 CB ARG A 86 9 .478 43 .233 13 .9.04 1 .00 45 .21 6 C ATOM 678 CG ARG A 86 8. .998 42 .836 15 .269 1 .00 45 .81 6 C ATOM 679 CD ARG A 86 7 .966 43. .769 15 . ' 870 1 .00 50 .08 6 C ATOM 680 NE ARG A 86 8. .533 45 .042 16 .316 1 .00 52 .09 7 N ATOM 681 CZ ARG A 86 7. .852 46 .184 16 .325 1 .00 54 .44 6 C ATOM 682 NH1 ARG A- 86 6 .597 46 .122 15 .899 1. .00 55 .12 7 N ATOM 683 NH2 ARG A 86 8. .314 47. .370 16 .716 1 .00 54. .52 7 N ATOM 684 N GLY A 87 10. .306 40. .753 11, .814 1. .00 ' 41 .30 7 N ATOM 685 CA GLY A 87 10 .214 39 .368 11 .411 1 .00 38 .40 6 C ATOM 686 C GLY A 87 11, .594 38. .725 11. .390 ' 1, .00 37. .29 6 C ATOM 687 O GLY A 87 11. .646 37, .528 11. .374- 1. .00 37, .00 8 O ATOM 688 N GLU A 88 12, .737 39, .395 11, .492 1. .00 34 .87 7 N ATOM 689 CA GLU A 88 14 .028 38, .747 11 .507 1, .00 33 .51 6 C ATOM 690 C GLU A 88 14, .070 37. .846 12, .725 ' 1, .00 36, .42 6 C ATOM 691 O GLU " A 88 14, .853 36, .869 12 .683 1, .00 39 .36 8 O ATOM 692 CB GLU A 88 15, .202 39 . .721 11, .476 1, .00 31, .83 6 C ATOM ■ 693 CG GLU A 88 15. .237 40. ,606 10. .230 1. .00 26. .70 6 c ATOM. 694 CD GLU A 88 16, .268 41. .678 10, .478 1, .00 30, .70 6 c ATOM 695 OE1 GLU A 88 17, .242 41, .345 11, .210 1, .00 31, .05 8 O ATOM 696 OE2 GLU A 88 16. .182 42. .849 9. .996 1. .00 30. .69 8 O ATOM 697 N THR A 89 13, ,240 38. :ιoo 13, .769 1. .00 34. .68 7 N ATOM 698 CA THR A 89 13. .225 37. .183 14. ,882 1. .00 35. .28 6 C ATOM 699 C THR A 89 12, .697 35. ,837 14. ,444 1. ,00 35. .41 6 C ATOM 700 O THR A 89 13. .190 34. ,803 14. .881 1. ,00 38. .37 8 O ATOM 701 CB THR A 89 12, .315 37, .721 16. .003 1. ,00 40. .06 6 c ATOM 702 OG1 THR A 89 11. .000 37. .923 15, .417 1. ,00 42. ,92 8 0 ATOM 703 CG2 THR A 89 12. ,844 39. ,051 16. ,491 1, ,00 40. ,29 6 c ATOM 704 N GLU A 90 11. .741 35. ,652 13. ,589 1. .00 34. .81 7 N ATOM 705 CA GLU A 90 11. ,225 34 . ,363 13. ,233 1. ,00 39. ,76 6 C ATOM 706 C GLU A 90 12. ,142 33. ,512 12. ,396 1. ,00 39. ,51 ' 6 C ATOM 707 O GLU A 90 11. ,909 32. 323 12. ,437 1. ,00 .40. ,76 8 O ATOM ' 708 CB GLU A 90 9, ,875 34. ,461 12. .518 1. ,00 44. 99 6 C ATOM 709 CG GLU A 90 8. ,826 35. ,215 13. ,3.62 1, ,00 55. ,34 6 C ATOM 710 CD GLU A 90 7. ,485 35. ,264 12. ,648 1. ,00 59. 16 6 C ATOM 711 OE1 GLU A 90 7. ,639 35. 121 11. ,403 1. ,00 61. ,89 8 0 ATOM 712 OE2 GLU A 90 6. ,444 35. 428 13. ,331 1. 00 61. 11 8 0 ATOM 713 N ILE A 91 13. ,089 33. 970 11. ,623 1. ,00 38. 04 7 N ATOM 714 CA ILE A 91 14. ,010 33, 282 10. ,769 1. 00 33. 30 6 C ATOM 715 C ILE A 91 15. ,337 33. 072 11. 508 1. 00 34. 96 6 c ATOM 716 O ILE A 91 16. ,279 32. 582 10. ,883 1. 00 37. 55 8 0 ATOM 717 CB ILE A 91 14. 461 34. 074 9. .501 1. 00 29. 78 6 c ATOM 718 CGI ILE A 91 14. 929 35. 487 9. 792 1. 00 27. 82 6 c ATOM 719 CG2 ILE A 91 13. 329 34. 252 8. 509 1. 00 27. 01 6 c ATOM 720 CD1 < ILE A 91 15. 487 36. 167 8. 500 1. 00 26. 88 6 c ATOM 721 N ILE A' 92 15. .504 33. 451 12. 773 1. 00 31. 69 7 N ATOM 722 CA ' ILE A 92 16. 737 33. 126 13. .420 1. 00 29. 83 6 C ATOM .723 C ILE A 92 16. .469 32. 149 14. ,588 1. ,00 29. .38 6 C ATOM 724 O ILE A 92 17. 417 31. 545 15. 161 1. 00 32. 63 8 O ATOM 725 CB ILE A 92 ■ 17. 417 34. 418 13. 954 1. 00 29. 20 6 C ATOM 726 CGI ILE A 92 18. .886 34. 099 14. .253 1. 00 30. 18 6 C ^H^HI^ ' '--ι-_f--H!-3^H-rtι-3(-3Hι-3ι--i-3H- ι-- ι--Hι--H3β'--HHH'-aHHHβ oooooooooooooooooooooooooooooooooooooo.ooooooooooooooooooooooo -~J^-- -J-J-J-J-J-J-J--J-J-- -- --J--J^--0-J-J-J-J-J--J--J--J--J-- --J-J coco∞co∞cocnco-j-j--j. --j^-j^^-jσι-nσιcr)σιcrϊσ _ncFicn ^ J0lU1^WMHOU)C0^CΛLnt»U)MHOlD00%lCήIIl^ -)MH θωα) J ΛUlι ωWHθωω lm01Λ lJN μθ l0C0 l(JιUlιl-ω o π o O o Ω oon O Ω Ω -S S O O O O O OΩZ; OΩΩ O O O ≥; Ω O Ω O O O 2 O O Ω Ω Ω O O Ω 2; O O Ω Ω Ω O Ω Ω --: Ω Ω D OW ^ azgoE- * W ffi CSi p O Ω tt) HH O Ot ^ O O ttl s Ω Ω t if HH D fitfl M H O Ω trJ σ Ω W I- 1 M K> M M l-" M M M M f τ3 T) rϋ i t) rrj rI 'T- l ^ , D= ) 1 Ω Ω Ω Ω Ω Ω O Ω < <; < < < '-- '-3 »-- >-- '^ '-- Ω Ω Ω Ω Ω (Π (Π Ω Q Ω Ω Ω Ώ Ω Ω Ώ Ω Ω H H t 1 i^ ir , ir< t< ir , ir< ir'tr^;p lp :y p re !-- ffi;-- ffiffi ^ H M B KWMfl QΩ a θO O Q OQan2 ZZ 2 Z2i Z 2! a SO SO SO SO SO SO SO SO SO SO SO SO SD SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SP SO SO SO SO SΩ SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SD ^ I_3 U> (_3 IO -O I_D I-3 -O OO CO ∞ ∞ CO ∞ OO CB CO ∞ -J -J --J -O -J -J -J --J -J CO c oo M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M co UJ LO M O CD O U3 kO O O lβ O O U3 ∞ M >I-- ω iΛ) U1 ^ -J σ) ---l » Cσ CO CO ∞ ∞ ^ (3^ U10 --J n M ιfc σi o υι crι CO M J-- ^ CO M 3 αi ι(^ Ul M O --J Cθ σι -J X) M -O --J CΛ θ ωocnouιcncr>σcocnii->>4^^oo---j(-oωo-rι rιθu3 U5ωtø >C- ---l J-. t£> α-. M -J ~-' ω -^ CD M CJ CO M ιJ-- (π -J U3 CΛ M Uπ M O ιI-. M .I-- l-3 ∞ m M M M M M M M M M M M M M M M M M M M M M M M M M M M ω ω ω M M M M M M M M M M M M M M M M M M M M (- U) ϋJ <0 ( jϋ M M OJ J - 0 O -J -J cn yι c ( -π ω -^ ij M ( jJ >ι^ ω 'i^ --» cι --J -J ---- σi cΛ (jι uι σι ∞ I m ω u3 M ∞ M O C001 --J '-J --- CX> M M --J CΛ ιI^ ιI^ CD O M M (yι M ---- C0 σ M M OO U1 ^1 il- (H iI- ^ -J A M N ia C- Ul -J l>J it> Ul -J H IJl iI- ) CD J- H ^ I M O N a) oo cD 4^ (Λ crι θJ rι <J M ijJ -J ιt^ ι ) ω σι σι -o j-. o o o ω σ Λ U3 ^ ui ιJ^ j σι m C0 C0 -J (jJ lD O C0 tn J-. 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LπoMω --J -ocoω uiuiciow oωωH co -.H Ni μ ui OH oo o oo - j o ^ ^ ii σiUiui oco μ HmiD-ofc O -itΛHcooio -j co μ .i μ u co iD ω ww cτ> crι σι co crι σ^ ^ ^ ^ crι ^ cΛ CΛ θ^ oo y icrι ^ --J cϊ ) crι c Λ 3 crι σ^ ^ Λ Ω Ω Ω 0 Ω Ω -32; S Ω 2 Ω Ω Ω 0001Zi a 00 Ω O 0 Ω Ω 20 Ω Ω 0 Ω Ω Zl 0000 O Ω S 00 O 0 Ω 0 O Ω !z; 000000 Ω Ω 2; Ω 0 CO CO ∞ CO oa oo αa co oo σo co oo ∞ oo oo co co co ∞ ∞ ∞ ∞ co oo co m oD ∞ co co ∞ Φ- i ^t. ^ J^ J-. ^ d^ ^ d-. ω ω ω ω ω ω ω ω ω LO M M M M M W M M M O O O O O O O O O O ^ CO i o> ϋi Λ U M μ o a -) i m ιn -. 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O lO υ3 ι --. αι (^ O M Ul W M --J Ul Co ω <-^ m vi ω J in αi oi w M iD O ϋi H U ϋi M φ N ω Λ io o ω oi inN ^ fc -J Λ CD m w oi Λ o o-^ o m fc in u M μ μiD Ui w o μ co αi o μ fc Ui o -J oi σι oo cn -J Λ θ -D ω co σι jι o u3 iD ^ --J cn --J tø αι ω (jJ M -J M θ ∞ ( jπ σi U5 OT U3 ^ -^ t μ μ μ μ μ μ >- l-> i-' l-' i-> l-' -' l-> 1-^ -> h- 1 t-' h-> t- 1 H* -> 1-* -> t-> f-' CZi O O Ci i l-' l-' t-' l-' l-' t-' l-' i-' l-' l- 1 oooooooooσoooooooooooσoooooooooooσoooσoooooooσooooooooooooooo ooσoooooooooooσooooooooooσoooooooσoooσoooooooσoooooooσooooooo Mω -jωoj ICHOOlβiMjlOl ϋι*.o tn-j(> -lI0001 Mμ θ CΛ O > -J ∞ rø σ Ch Ω Ω 200 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω 0 Ω 02;Ω 0 Ω 0Ω 02! 0 Ω Ω 2; Ω ΩΩ 0 ΩΩ!2;Ω 0 Ω Ω 2; 00Ω Ω Ω0Ω Ω≥; ΩΩ 0 ΩΩ !2! -3 -2 ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggg Ω O a O O Ω»Ω O Ω Ω OΩΩ3ΩΩΩOOΩ Z O CG Ω O O O Ω Z Ω CG O O O ΩΩ S OΩΩΩ O Ω O S- O O O Ω O O O ZΪO O Ω S Ω O £> D O Ω ω > Ω Ω (U M O Ω W M O G. CrJ D Ω Ω tS σ θ Ω W ^ ω M M M M M M M SSSSSSSSS-SSSSSSS t-i l-H i-i t-> -i t-i H M H H H co co ω c co — — ' ' ' ■ " ' ' - Ui U> CΛ tn >τ) >τl 'x) <V t ϋ fτ) fl fl r l t t r P μ r 1 ^ ^ H H ^ ^ ^ H H H ^ H H ^ ^ M ta H I?l tfl H H HΛ fl i fl ^ 'fl i t) i β ιO hi κ; κ; it | "J M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M -' M M M M M M M M M M M M I-' M M M M M M M M M M M M M 5 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ^ ^ J-. ^ U) ω ω ) (θ ω ω ) M M M M M O O O O O O O O l ι U3 υ3 lD U3 CO U? C-500 CO ∞ ) 00 CO c ΓD M M M M M M M M M M M M M M t Lϋ o ω Ul M M LO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M t M M M M M M M co σi ui w m -J -j i m ui m -J ω ui ω o o o H Q iD iD o ω ω i -j -J uj co i J i J a ^ cn m ffl W ioM O N ^ Λ M M ω o io o N N H ω w M o M J^ CTl » ∞ M Λ M U3 O M CΛ ^ 00 l_0 Ul -J .I^ O t£> O - M Cj1 crι M ∞ ∞ <_π ω u3 Co ι > o co uι ^ -J oι -J ϋι <-n co o ) ^ ω tA) ω -^ cΛ --- --J crι M CΛ αι M ∞ o o ω * ) <iι _ι i!) fc (!i w αJ o ijι oι -J uι w o j co σi i ιj3 θ vi M u ω ω ^ θ Λ fc W vi ^ M iθ vi (Λ (Λ Ui ifl μ ^ *, U) θ tD io θ fc μ o is θ ι- u iι) m ^ ι4^. j^ ιi-. 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Uπ Ul Ul C 103 Un CI ) ιI^ M Ui ω 7J ϋ j ω ω oj ω j C M W W Ul W m <_π „^ 3 --J O O » U3 ∞ U3 -O U3 α iO UJ M .fe lD O C0 M CO lJ ] ( ^ M^ M OO M M O C^ θn CO O CO M --J C^ ) --J ^ OO ∞ c ιI^ i ω ---J -J U10o ω o U1 σ} < > ^ σi d^ to ra ^ o ^ ω tJ Λ io ιo ω ^ ft ^ ω ^ ^ (Λ μ o M oo μ ij u co ^ M (jι w m uι U ι-- o -J i ι μ ^ o θ Λ Φ θ iD ip i iB H ιi- (jj w uι o M J ui H ( MMMMOOOOMM MMM M M M M M M M M M M M M MMMMMMMMMMMMMM MMMMMMMM σoooooooooσoooooooooooooooσooooooooooooσoooooooooooooooooσooo oooooooooooooooooooooooo.ooσooooσoooooooσooooooooooooσoooooooo M-.4^ι(-.ιi^ M M--.u-.ιj-.α^^α^ )---L->cυ )-^^ωωι--'ωωcjω Mω o<-π<^uιui U>>ι^uιθ iθ ]oσ i£>ωMCD--j∞o.J--u><^--J-J coθcΛσιθθθθ<jntπσι-JiΛU>co nu3 -JUπU>Mcη x>-Jcnoσγoϊ>ιft σιW ωooooω i jθMco-->ωθfi- « <-3 nωω u3^o∞∞∞cnowω-Jω M M CDcricn^cococ -Λ∞ yιcrι-ocoo^cn-JcnσιcΛ∞c cΛ ιo^cnσι O OΩ S O O O O OΩ Ωg OΩΩSΩ Ω Ω O O O S- Ω tαO Ω OΩΩZΩωOOOΩΩ ZiΩOΩ ΩO ΩΩ aoσ OΩO O O Sa OOΩa ΩO ' pa S=' 3a |)=ι ^ ι a pa iιa ι ' OOOOOOOOOOOOOOOOOOOOO ό-όόόόόόdόό_ooooooooo O O O O O O O O O O O O O O O O O O O O O ggggggggggggggggggggggggggggggg MMMMMMMMMMMM MMMMM MM- t-> l-> t-' l~> i~' l-' l-' -* l-> t-ι \- i h-' >-' O O O O O 00 O O O O O O O O O O O O O O 0 O 0 O O O O O O O O (J3 ^ l£> i-3 <£i ^ l UJ M M M M M M M M M M M M M M M M M M M M O O O O O O O O O CD 3 ^U5 U3 U5 U3 CO U3 U30003 C» Oa CO CO CX) CO Ca cO -J - -J -J -- ^ ^ J ^ l -4 oωco iraiΛii- ji M.O iBro jβi i^ωiuμoiooj^mϋifct-Mμoioffl-JcΛUiii-ωMμoiDαisJiΛuiJ- iw oiDcoJoiuiΛUMμ OOΩΩZOΩOΩΩ 2500 Ω Ω Ω O Ω Ω -3 O Ω Ω -3 Ω Ω Ω Ω O Ω Ω O O Ω Ω Ω Ω Ω Ω O Ω Ω O Ω Ω Ω Ω Ω Ω O Ω Ω a 2 Ω Ω Z Ω Ω tn Ώ tn. P=< pin rj nu O Ω Ω trJ K N HMDa O tB > N M M DDΩ B > tt P- O O Ω tjd M M M M M M M M M M M M M M M M M te ω ω ω ω CΛ CQ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω H H H H H rf ι-3 H 3 H ι-3 H ι-3 H H H ι-3 'Η Ω ^ 3 fa 3 ra ra ^ 3 iτ3 l-- ^ E H M M M H H M I^ !→ tr , tr , lr < tr l ^ !r 1 lr < tr H !r , lr 1 - ~ tr , t^ > |> a |f M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M W U) 1J O ( J 0 C0 C Λ ) C-) UJ 0J C-J M M M M M M M M M M M M M M M M M M M M M M M M M M ISJ M M W M M M M M M M M M M M M M M M M M M M M M M M M O O O O O O IJ3 U3 U> U3 *-3 UD I-O U3 <-3 CO ∞ CX> CO -J -J ^ --J -J --J --J --^ MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM ΛCTϊ 0--J----0∞l£>OOC0 » -o ω o θ ιi-- ω o -^ c ι uι oo cn '-3 ιi^ D ∞ Un ro cΛ I-5 M M θ ω -J IjJ -0 CΛ) -J I-3 O l £ l --J CD ^ O -^ l M M -J M O C Cp C0 ω M αι υ-l I CD O ) C ω M M <_π cjι (j-i (π <_π uι uι c^ J^ ω ιI-. ( ij M M M O ϋπ --J <-π --J O U300 ∞ o iD co i£) H U3 H ∞ ui H Ni ui φ ft ω -iι j o ω j ιfr H i W M θ *> M α> 'J (iι ιo iJ M m ω ιι> ϋι o μ ι σι w * f> W -io w ioμμ uJO i o i μ u o uiNi o o ui ww ω MU iΛ Ui co i- ui μo oi oi Js μ iD ω ft ^ isiii H i μ Λ ω ∞ >ι^ ω i-3 i-3 Cϊϊ Ui ω --j -Λ ∞ »ι^ WMMMMMMNMMMMMMMNMMωUωωω-jωUMMωωMNωMϋOMωω ^ ^ fr ^ fi Λ Ui -i oi m iD -J ω co m -j co a ^ i ω M M o ^ iD O O -i o o i o iø o o o M ii- ui ^ ui ^ ^ O -- ^ σ -i M l0 Cϋ cJl Jl (-π M Λ -J ∞ M ^ -^ J^ CJ ω M U3 O ω M O M σ CΛ M Ul C^ M l£> Ul M M (j Ul M C U> M Φ- --J U103 <3 ω θ <£> CD -^ M M ω ω M --J ιJ^ 3 <^ σ >l^ ω t CD h-' }~' t-> l- t t- i t-' - i - i I-' t-> - 1 \-> b-> t-> i-' i-' l-' i-' -' t-' i-' -' l-' ^ l-' t-' l-' t-' i-' t-' t-' -^ l-> -' l-' t-' t- i t- i ^-' t- 1 t-' t-' i-' l-' y- i t-' l- i t-^ l OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ' OOOOOOOOOOOOOOOO ooooooooooooooooooσooooooooσoooooooσoooooooσooooooooσoooooooσ ^_. jι ι^ ιJ^ ιi-. ^ »ι^ '-^ * i-. »^ ^ Lπ (ι uι αι (J-ι ^ ιi-. ιj-. ι^ ™ ^ 4-. ^ ^ tθ ι^ i θ vi -j * J Ui M w ω ω σι iϊ vi uι W u ij ω α) i ω M N ή μ H ιιι u fc ^ w ι u o » o uι Ni ϊ) ω M θ o ιi) m » H iΛ) H μ M (jι ui fc ϋι M i O lj3 M C^ O Cπ αi ^ U3 M ∞ rø cn θJ >fe C CX> Jl ι > U3 U3 σϊ CΛ Ul M ι!-. J-. l_3 ω C_π --J σι M Oθ σι --J O ιt^ Ul Lυ M CΛ Ul Ul -π O ιfc >I-. G --J crι σι M M Ul Ul O cn ∞ cn σι -J ∞ crι ∞ τi crι ---- ∞ ∞ o σϊ -n oo σ> cn ---J co σι yι O O Ω Ω a O O O Ω Ω -S O O O Ω Ω O Ω Ω Zl O O Ω Zl Ω Ω Ω Ω O O Ω Zj O O O O Ω Ω Ω Ω O Ω Ω a Ω O Ω Ω O Ω Ω O Ω Ω a g Ω Ω S Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ps pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O Q O O O S S S S S S S IS 3 S S S S.S S 322222222222222222222222 s 22 s 22222222232222222 g MMMMMMMMMMMMMMMM MMMMMMMMMMMM oooooooooooooooo oooooooooooo t>ι>i£>ooco x> 3Cocx)coc)Cθoo- ---j--j 3 o iD -i J Ui Λ Ui M H o a o J ) U H θ i- ∞ i m iJi ιi- U M aaaΩa ΩOO 2; Ω 0 Ω Ω a 00 Ω 200 Ω Ω Ω 0 Ω Ω 300 Ω Ω -S S O O O O O Ω S- Ω O O O Ω Ω ZJ S S Ω S Ω Ω Ω O Ω Ω Z KffiNHO Ω-ω CD pa M H O C1 B pa td pa D DOIJ pa Ω Ω C a IB S JSi H O O tfl p M M M M M M M pa pa p0 f0 faΩ Ω ΩΩΩ ΩΩΩ Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ M M M M M M M M M M M M M M M M I-' M M M M H-' M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ^ (jj ω ω ω ω J ω ω i ω o co ω ω ω ω Lo i ω ϋJ -Λj oα ω O I_3 lD I£> U) l£> l_3 lQ IJ3 ^ U3 lO OO OO CO CO OO --J ^ -J --- Cri CiN m Cf1 Cri C^ M M A H Λ ( Oo ω J - ω ω ω U) (ϋ (jϋ Cϋ M J ( J M M M M M M M M M M c o μ ω M w ω u w M μ o O O ∞ ω Λ iji ii o o o iD a m ^ -> Λ U) μ μμ o uι oi Ni uι o m μ ω o) (i) ^ uι o oιi!i iΛ K) β) o μ inMw cn (ii Λ -i * θ M o ω o (S -J iΛ ω fc Λ j (i) fe (ii o j ijι ω ∞ M θ w M M -J ι& Ul M --J U> O U30^ ω i-3 CO M U> 030 σN M O Ul M I-D M Ul Ul O O M θ α} (Jl O M -J to (iι ^ μ Mμ w fe σι κ ωiΛ θ θCΛ ωiD CD θi N) ω μ w m ω * o uι iw u j * ιo∞ μ o3 θ M o _i i u M iD μ(iι (!i u θ iD U ii) uι tfι ϋi ϋι MOOOOOOM MMMMMMMMMMMM M M M M M M ^ I- 1 I- 1 t-' ' MMMOOOOOOMMMMM oooooooσooooooooooσoooooooσoooooooooooooooooooooooooooooooooo oooooooσoooooooooσooooooooσooooσ oooσooooooooooooooooooσooooo W M M .I^ (f^ ~^ ^ ^ AΪ .I^ > <^ ϋ »!-* .I^ --. d^ (Jl Un »I^ i-. ιi^ 4-. ω uιuι ϋi (fl iΛ iΛ oiι- w o ao ωco u μ μ M θ M D -j U Λ ω μ a o o H Uθ) Ui uιW iD ω μ o oww wN θ (Λθi uιuιϋι oι t. o μ u (jι -i o o o o o o o μ co iD μ ( ϊι - j m - ) ffl ϋi ^ Lrι ui (!i 5i μ ω ω o αi i ι j - N (Λ θ -) ω (iι μ w M *. --ι ij) uι *. μ j- o o o o o o μ N M (Λ ω (^ OO O O O O UCO W ∞ U l J MM lD O φID Mω l Jω lJ ΛO μM lOIJm iflW Λ ϋl tn lO ifc J U J løω W lJl Ul U O O OO O O lO O CO M Ol •-J -J ^ σ) -J σ^ cτ σι co cr> cn ^ σϊ ∞ r) cn ^ x> cn σι --- ∞ co σN σN cr> ∞ aao ΩΩOoo ziΩooosoo zoooo ooΩaΩO oaaoo ooo ΩOΩoooaaaΩaΩΩΩOΩΩa ATOM 1093 CA GLN A 140 11.117 42.869 30.448 1.00 39.67 6 C ATOM 1094 C GLN A 140 12 .462 42 .180 30 .341 1 .00 41 .42 6 C ATOM 1095 O GLN A 140 12 .716 41 .103 30 .948 1 .00 45 .50 8 O ATOM 1096 CB GLN A 140 10 .346 42 .761 29 .167 1 .00 37 .83 6 C ATOM 1097 CG GLN A 140 8 .827 42 .602 29 .143 1 .00 36 .27 6 C ATOM 1098 CD GLN A 140 8 .311 42 .390 27 .706 1 .00 40 .74 6 C ATOM 1099 OE1 GLN A 140 8 .679- 41 .352 27 .056 1 .00 42 .86 8 0 ATOM 1100 NE2 GLN A 140 7 .477 43 .262 27 .087 1 .00 36 .53 7 N ATOM 1101 N MET A 141 13 .390 42 .817 29 .615 1 .00 41 .08 7 N ATOM 1102 CA MET A 141 14 .715 42 .234 29 .468 1 .00 39 .01 6 C ATOM 1103 C MET A 141 15 .329 42 .133 30 .836 1 .00 37 .86 6 C ATOM 1104 O MET A 141 15 .689 40 .979 31 .086 1 .00 39 .52 8 -0 ATOM 1105 CB MET A 141 15 .665 42 .985 28 .523 1 .00 41 .84 6 C ATOM 1106 CG MET ' A 141 17 .049 42 .300 28 .317 1 .00 41 .33 6 C ATOM ' 1107 SD MET A 141 16 .917 40, .673 27 .510 1 .00 43 .02 16 S ATOM 1108 CE MET A 141 16 .580 40 .996 25 .803 1 .00 39 .58 6 - C ATOM 1109 N ILE A 142 15 .439 43 .186 31 .669 1 .00 36 .75 7 N ATOM 1110 CA ILE A 142 16 .038 42 .969 32 .994 1 .00 38 .20 6 C ATOM 1111 C ILE A 142 15. .372 41. .826 33, .797 1, .00 37. .42 6 C ATOM 1112 O ILE A 142 15 .985 41, .056 34 .527 1 .00 36. .17 8 0 ATOM 1113 CB ILE A 142 15, .911 44, .334 33 .709 1, .00 40, .47 6 C ATOM 1114 CGI ILE A 142 16, .728 45. ,345 32, .910 1, .00 40, .83 6 C ATOM 1115 CG2 ILE A 142 16, .293 ' 44, .230 35 .163 1, .00 41, .86 6 c ATOM 1116 CD1 ILE A 142 16 .753 46, .768 33 .350 1 .00 40 .25 6 c ATOM 1117 N ALA A 143 14 .062 41 .655 33 .617 1, .00 36 .53 7 N ATOM 1118 CA ALA A 143 13. .292 40. ,648 34 . .301 1, , 00 39, .03 6 C ATOM 1119 C ALA A 143 13, .765 39, .255 33, .886 1. .00 44. .10 6 C ATOM . 1120 O ALA A 143 13. .974 38, .366 34, .749 1. .00 44. .96 8 O ATOM 1121 CB ALA A 143 11, .815 40. .822 34, .008 1, ,00 35. .82 6 C ATOM 1122 N ILE A 144 13, .917 39, .114 32. .516 1. .00 44. .81 7 N ATOM 1123 CA ILE A 144 14, .407 ■ 37. .802 32, .055 1. ,00 42, .08 6 C ATOM • 1124 C ILE A 144 15, .812 37. .547 32, .537 1. .00 43. .57 6 C ATOM 1125 O ILE A 144 15, ,977 36. ,393 32 . ,984 1. ,00 46. .89 8 O ATOM 1126 CB ILE A 144 14. .393 37. ,682 30. ,561 1. 00 41. ,61 6 C ATOM 1127 CGI ILE A 144 12. ,920 37. ,640 30. .112 1. ,00 40. ,08 6 C ATOM 1128 CG2 ILE A 144 15. .139 36. ,461 30. .047 1. ,00 42. ,14 6 C ATOM 1129 CD1 ILE A 144 12. .611 38. ,327 28. .800 1. 00 37. ,77 6 C ATOM 1130 N LEU A 145 16. .695 38. ,534 32. .520 1. ,00 42. ,59 7 N ATOM 1131 CA LEU A 145 18. .025 38. .216 33. .032 1. ,00 43. ,71 6 C ATOM 1132 C LEU A 145 17. .957 37. ,823 34. .502 1. ,00 48-, ,43 6 . c ATOM 1133 O LEU A 145 18, ,828 36. ,987 34. .824 1. 00 49. .21 8 O ATOM 1134 CB LEU A 145 18. ,927 39. ,433 32. ,790 1. ,00 39. ,36 6 • c ATOM 1135 CG LEU A 145 19. ,169 39. 703 31, ,311 1. 00 38. 73 6 c ATOM 1136 GDI LEU A 145 19. ,773 41. 064 31. ,029 • 1. 00 39 . 04 6 c ATOM 1137 CD2 LEU A 145 20. ,041 38. ,584 30. ,726 1. 00 35. ,22 6 c ATOM 1138 N GLU A 146 16. ,999 38. 458 35. .236 1. 00 50. ,61 7 N ATOM 1139 CA GLU A 146 16. ,856 38. 201 36. ,662 1. 00 53. 29 6 C ATOM 1140 C GLU A . 146 16. ,438 36. 762 36. 933 1. 00 50. 86 6 C ATOM 1141 O GLU A ' 146 17. 061 36. 035 37. 724 1. 00 49. 36 8 O ATOM 1142 CB GLU A 146 15. 907 39. 231 37. 353 1. 00 53. 73 6 C ATOM 1143 CG GLU A 146 16. 777 40. 233 38. 120 1. 00 57. 30 6 c ATOM 1144 CD GLU A 146 16. 200 41. 622 38. ,128 1. 00 58. 80 6 c ATOM 1145 OE1 GLU A 146 14. 964 41. 606 37. 938 1. 00 61. 75 8 0 ATOM 1146 OE2 GLU A 146 16. ,872 42. 652 38. ,298 1. 00 57. 60 8 0 ATOM 1147 N' LYS A 147 15. 408 36. 425 36. 149 1. 00 49. 22 7 N ATOM 1148 CA LYS A 147 14. 886 35. 051 36. ,300 1. 00 50. 37 6 C ATOM 1149 C LYS A 147 15. 993 34. 027 36. 128 1. 00 53. 27 6 C ATOM 1150 O LYS A 147 16. 044 32. 960 36. 738 1. 00 56. 64 8 O ATOM 1151 CB LYS A 147 13. 733 34. 847 35. 332 1. 00 49. 38 6 C ATOM 1152 CG LYS A 147 13. 286 33. 440 35. 003 1. 00 48. 97 6 c ATOM 1153 CD LYS A 147 12. 369 33. 550 33. 767 1. 00 51. 71 6 c pa pa pa pa pa -ps pa pa pa pa pa pa pa pa |μ pa pa pa pa pa pa pa pa pa pa pa pa py pa pa pa pa ;> ι-- i-_ μ - H H H ι-3 H ι-3 ι-- i-- i-- μ - H ι-- i -- μ - i-- H μ - μ _ H !-- H !-- H ι-- H - i-- H3 H H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222223222222222222222222222222222222222222222222222222 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM.MMMMMMMMMMMMM μ μ μ μ o o o o o o o o o o -i ui iD io ui a ui ui ui ^ -i co cD -i t- co co αj m iii i ^ i i ^ i j i - j J Λ ή m cΛ m -i n m σi m ui ϋi ui iJi iii ui >I^ ) M M O CO O -J CΛ Ul Λ l > M O U5 CO --J CIN ( l ιfe ω M M O I£l CX3 --J Λ (-π ι& l ) M O l ι ∞ -J ^ Ω i— i OrTN Ωi ω-ri OΩ Ω OΩΩa Ω α Ώ ti ω pa N H pa pa pa ≥ pa <<<<<<<< <;<;<<<<ωcΛCoo-CoωΩΩΩΩcoωcocococoir , tr , t-'t-<c- 1 f ir 1 t→ΩΩOΩffiffiW ^rι |I! lI! ffi l ! p: !Il l^' t ~, pa |μ p3 pa pa pa pa pa pa pa pa H K t7- M I? M tr l i , t< lr' M H H ^ M H H M M M H KJ K; Ω Ω Ω Ω ~ Ω Ω Ω t < ^ r^P lr , ^ l→ l μ ir | μ ^ l→ μ ^ 3 |S iS » ^ ^ ^ lS^ |S !ι) α α α G α G αα κi κ; h<| κ; [n ωω (Λ co ω ω ω c c ω c pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa i-' t-' μμμ Hμ μμμμ μμ μμ μ μμ μμμ μμ μ μμμ U (jlιO_nlϋϋlιOulι σiσi oN fi M O O O O O O O O C£) U5 l ) l-D OO ∞ CO c co M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M o M M M M M O M ^ ^ ω θ M M O -J -J ^ O O U3 U3 M M O O O O U3 0 0 θ ω M M M M M -^ M M M O M M M M M O <-3 Un cyι C --J -J CO O CO Cθ σι M M ιχ> 3N cn M ^ u> o θ M αi c cD θ σι 3 ι ω ω σι co ri c^ ω uι oo σN θ j --J ∞ oo Λ M oa M ^ π ^ oo j^ ijs O M o^ OT cn σi ω Λ co cD ij^ ife CD iα J M -^ M ω M ^ ω oi ri n ω lB I M UHD i- *. « ) 03 M OJ l W l| ) M (n M (!ι ljι μ uι U (il CO M ω μ μ l- U1 0 U O O H ^ O IO ) M O Ul CD O M ( £l M -4 ιt-. M O (-O O M ιI-. Lϋ O CO Ul --J m uι u-ι ( ι uι σι ( ι uι uι σι Uι cri Ln un uι < ι i-π cπ αι uι uι uι -^ ιi^ ιi-- ^ "-^ co -J ^ -J σN ^ C^ (_π ι^ ϋJ J^ W σ M O O » CO OO OO CD Λ l Ol ^ (jα M M M '_3 U1 -n Ul --J l C^ m CTl M -J --J M Cn ^ O C0 υD M-M M ω ιfe ^ O 3 O ^ ^ l U3 O -J --4 rι ω --J U3 O M ω ι ι C0 cn ^ M ca m co μ .-. o ω ) o m ^ ιo θ -co ω * i cft ^ i M cfι ιfc fc αι ω co 1 θ j ^ ^ m j- uι μ (j o «) μ ω ^ u) αι ^ j ω u μ iΛ) iD θ M -J ιfc θ M ^ uι ω --■J il-. OT ife U3 .l-. CJN O M M -J CO U3 Cn D ri U3 iI-- »-' -0 --J l 3 LJ -J -^ ϋj ω M M M Lϋ M ω i ω jcj ωω ω c N μ iDoi J iii φ o io ω -iiooo M o μMμ μwμN WiJW Ui inuiwω m o M m φ * ∞ ui ] N ) u M W Ui θ i ιo tΛ aι ω Ui o i£> ^ -J U ιi- αι o N ) μ w O U> ) C CO -^ ^ ω cτι --J M M Crι tA) U ) C to CO O σN W ιl^ Crι r> >-- cn cr) < JI CX> O Cπ Ul M O M M M M M M M t-' i-' l-' )-> l^ ]-' -> l-' \-' i-' -^ i-' >-^ t-' i- l~' t- i i- i t-' M M M M M M M M M ooooooooooooσooooooooooσoooooooooooooooooooσoσoooooooooooσooo oooooooooooooooooooooooooooooooooooooooooooooσooooooσoooooooo oo o oo co σi G^ αo u> o <£> ω oσ u3 ∞ (^Λ σϊ ---JM --jω M Cjι ω tπ ∞ θ σι ∞ o ∞ uι o uι ω uι ~-' ( -n M σϊ M M∞ M -^ i £> σN θι .ι^ M M ∞ ω ι^ 'i^ o o M oo M o σι m <^ cx> cΛ Λ ^ σι σN σι α> crιcr> --J σι σNσN θo.σ\ α^ -j cx> c^ Ω Ω Ω O Ω Ω a Ω Ω Ω O Ω Ω a Ω Ω Ω O Ω Ω a θ Ω O Ω θ a θ Ω Ω a θ Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω a θ Ω Ω a 2 Ω Ω a Ω Ω O Ω Ω a a Ω O 02/16615 60 ATOM 1215 NE ARG A 156 22 .810 57 .432 33 .454 0 .00 25 .00 7 N ATOM 1216 CZ ARG A 156 23 .586 57 .983 34 .385 0 .00 25 .00 6 C ATOM 1217 NH1 ARG A 156 24 .553 58 .818 34 .034 0 .00 25 .00 7 N ATOM 1218 NH2 ARG A 156 23 .390 57 .700 35 .668 0 .00 25 .00 7 N ATOM 1219 N LEU A 157 20 .722 57 .532 26 .660 0 .00 25 .00 7 N ATOM 1220 CA LEU A 157 21 .081 57 .650 25 .255 0 .00 25 .00 6 C ATOM 1221 C LEU A 157 20 .428 58 .798 24 .523 0 .00 25 .00 6 C ATOM 1222 O LEU A 157 19 .216 58 .985 24 .607 0 .00 25 .00 8 O ATOM 1223 CB LEU A 157 20 .789 56 .356 24 .500 0 .00 25 .00 6 C ATOM 1224 CG LEU A 157 22 .011 55 .579 24 .005 0 .00 25 .00 6 C ATOM 1225 CD1 LEU A 157 21 .588 54 .422 23 .115 0 .00 25 .00 6 C ATOM 1226 CD2 LEU A 157 22 .976 56 .497 23 .267 0 .00 25 .00 6 C ATOM 1227 N GLU A 158 21 .220 59 .559 23 .756 0 .00 25 .00 7 N ATOM 1228 CA ' GLU A 158 20 .640 60 .691 23 .068 0 .00 25 .00 6 C ATOM ' 1229 C GLU-A 158 21 .137 60 .957 21 .650 0 .00 25 .00 6 C ATOM 1230 O GLU A 158 20 .308 61 .357 20 .793 0 .00 25 .00 8 O ATOM 1231 CB GLU A 158 20 .771 61 .968 23 .922 0 .00 25 .00 6. C ATOM 1232 CG GLU A 158 19 .589 62 .199 24 .887 0 .00 25 .00 6 C ATOM 1233 CD GLU A 158 19 .602, 63 .581 25 .530 0 .00 25 .00 6 C ATOM 1234 OE1 GLU A 158 20. .430 64 .417 25 .112 0, .00 25 .00 8 ' O ATOM 1235 OE2 GLU A 158 18. .790- 63 ' , .832 26 .450 0, .00 25 .00 8 O ATOM 1236 N LYS A- 159 22, .462 60, .772 21, .433 0, .00 25, .00 7 N ATOM 1237 CA LYS A 159 22, .991 61, .144 20 .126 0, .00 25 .00 6 C ATOM 1238 C LYS A 159 23. .362 59. .910 19. .311 0. .00 25, .00 6 C ATOM 1239 O LYS A 159 23, .767 60 .106 18. .108 0, .00 25 .00 8 O ATOM 1240 CB LYS A 159 24 .208 62 .058 20 .280 0, .00 25 .00 6 C ATOM 1241 CG LYS A 159 23, .887 63 . .425 20. .863 0. .00 25, .00 6 C ATOM . 1242 CD LYS A 159 25, .139 64 . .279 20, .988 0, .00 25 .00 6 C ATOM 1243 CE LYS A 159 24 .818 65 .645 21, .571 0, .00 25, .00 6 C ATOM 1244 NZ LYS A 159 • 26, .036 66. .494 21, .699 0. .00 25 .00 7 N ATOM 1245 N VAL A 160 23. .237 58. .708 19. ,844 0. ,00 25, .00 ' 7 N " ATOM 1246 CA VAL A 160 23. ,567 57. .564 18. ,991 0. ,00 25. .00 6 C ATOM 1247 C VAL A 160 22. ,378 56. .607 18. .980 0. ,00 25. .00 6 C ATOM 1248 O VAL A 160 21. ,535 56, .495 19. .896 0. .00 25. .00 .8 0 ATOM 1249 CB VAL A 160 24. ,887 56. .880 19. .362 0. ,00 25. .00 6 C ATOM- 1250 CGI VAL A 160 25. .955 - 57. ,388 18. ,365 0. 00 25. .00 6 C ATOM 1251 CG2 VAL A 160 25. .306 57. ,085 20. ,828 0. ,00 25. ,00 6 C ATOM 1252 N LEU A 161 22. .370 55. ,868 17, .863 0. ,00 25. .00 7 N ATOM 1253 CA LEU A 161 21. ,290 54, .930 17. ,580 0. ,00 25. .00 6 C ATOM 1254 C LEU A 161 21. ,295 53. ,769 18. ,569. 0. ,00 25. ,00 6 C ATOM 1255 O LEU A 161 20. ,224 53. ,278 19. ,002 0. 00 25. ,00 8 0 ATOM 1256 CB LEU A 161 21. 398 54 . 402 16. 148 0. 00 .25. 00 6 C ATOM 1257 CG LEU A 161 - 21. 211 55. ,431 15. 031 0. 00 25. , ' 00 , 6 c ATOM 1258 GDI LEU A 161 21. ,488 54. ,805 13. ,673 0. 00 25. 00 6 c ATOM 1259 CD2 LEU A 161 19. 787 55. 964 15. 026 0. 00 25. 00 6 c ATOM 1260 N HIS A 162 22-. 353 53. 238 18. 779 1. 00 54. 50- 7 N ATOM 1261 CA HIS A 162 22. 513 52. 125 19. 666 1. 00 54. 83 6 c ATOM 1262 C HIS A 162 23. 579 52. 423 20. 720 1. 00 54. 76 6 c ATOM 1263 O HIS A 162 24. 469 .53'. ,214 20. 505 1. 00 56. 54 8 O ATOM 1264 CB HIS A 162 22. 964 50. 820 19. 007 1. 00 58. 46 6 c ATOM 1265 CG HIS A 162 21. 968 50. 106 18. 143 1. 00 57. 90 6 c ATOM 1266 ND1 HIS A 162 22. 302 49. 386 ' 17. 034 1. 00 57. 48 7 N ATOM 1267 CD2 HIS A 162 20. 623 50. 002 18. 227 1. 00 57. 16 6 c ATOM 1268 CE1 HIS A 162 21. 196 48. 880 16. 489 1. 00 57. 03 6 c ATOM 1269 NE2- HIS A 162 20. 151 49. 238 17. 196 1. 00 55. 43 7 N ATOM 1270 N LEU A -163 23. 422 51. 692 21. 826 1. 00 53. 46 7 N ATOM 1271 CA LEU A 163 24. 376 51. 832 22. 898 1. 00 49. 16 6 c ATOM 1272 C LEU A 163 25. 753 51. 557 22. 314 1. 00 46. 30 6 c ATOM 1273 O • LEU A 163 26. 580 52. 390 22. 573 1. 00 44. 20 8 0 ATOM 1274 CB LEU A 163 24. 073 50. 869 24 . 038 1. 00 48. 44 6 c ATOM ' 1275 CG LEU A 163 25. 226 ' 50. 956 25. 082 1. 00 50. 03 6 c pa pa pa py p y pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H3 H3 3 H- t-3 H9 H >-- !^ H - H3 H '-- >-- i-- i-3 rt i-- rt H- i-3 i-a - H3 >-3 i-_ H3 H H ^H i-3 H H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo 22222222222232222222222 2222333222233333222222233222222222222 i— i— MMt— i— MMM l—M t—Mi—Mi—M t—Mi—Mi—Mi—MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM ω ω o ui ω ω i ω ω ω cjj ω ω ω ω ω ω ω ui w ω ω ω J ϋα > ω ω ωω M M M M M M M M M M M M M M M M M M M M O O O O O O O O O θ υ3 CD U3 CD U3 U3 3 3 U3 CO ∞ CO CX) CD OO CO ∞ c uι >ι^ ω M M 0 ij ? ∞ --J σ» <-π ι& ω M 0 ω » --J Λ ϋ i ιi -. ω M M 0 U 3 ∞ -^ I- J l- a ' I--' M I- , t-' (-- , l-- , I-' I-- 1 -o -j -j -j -j ^ -j ^ -j ^ ^ ^ ^ -j c n c cfi cn cn cn Λ cn σ^ cΛ C^ o cn c cri cri sN cri c^ M M M M M M O O O O O O O O CO CO CD CP CO U3 U3 U3 CO C£> CΩ CO CO ∞ ∞ CX> CO -J -ϋ ^ --J -J CO c 00 ω ω ω ω ω ϋJ O ϋ j ijj ω ϋJ L ϋj ω J ω ijj ijj c ω ω co σι -J co co ^ι σι oι ω j co co i -J Λ -i ιi- *. j- u) ιi- i M pi- J- ω ι ω.j- WM M o co ω o o H μ o H O io D ^i oi n tø co ^i ^i ^i h i -J -J o j ^ i ui ui ui J^ l£> M O -J U3 U3 ∞ Cϋ Ul -π M M *» CD M lO (J-l U> σ N CO (jO ∞ l£> M ∞ -J -J l£> <^ ∞ j - N Ui *"4 H cD ai M U) <ji t. -J o ai u oi O) -i fi CO D oo ~-. - j σι o w ω cϋ M o oι ω u oι co π σι -J -J <τι w ω c^ --J θ σN Cθ θ -π M ∞ uι oo ,ι-. υ3 --J D jι ϋJ »-- ) o ∞ o σN cn ω uι xι u ) oo cΛ ω cri cyι ω M M θ c3 m „-> „^ ,C- .I-. J^ J^ .I-. ιt- ιl^ --. --. ^ ^ ιJ-. -^ -i. J-. ιJ^ ιl^ ~^ ~-. ιI^ co o o θJ ω <π crι cι ^ ω μ-- -n ω ij j ω uι ( jj ( ji ι j ^ ϋι ^ ( _π σN rι ^ ∞ -J o u^ m M ID C0 ie U M U«) O -) m U M M ω U) O M Λ -J CD M N3 O O UI lB W Cfι 'Il -5 U) -l lJl Λ μ W M Uι ω Ul U ω U1 Ctι ω ^ N o μ ω io μ u ω oi Λ i M u o u o oo M u iD ω oi U ffl i^ βi io u o u io u iii iΛ M i fc μ oi H W i i μ iji u io o ^ μ iD iΛ io μ ffl O fr m i --J Ui co co cD Ui σι θ -ri M (Λ -^ o ^ ∞ crι r> c) cn ιJ^ oo oo r> θ Cxι --j ^ -^ j- ^ 73 M M W M M M M M M M M M M M O W M ω M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M f M M M M M M M M M C --J α3 θ3 CD -D --J M ω (jJ ιi^ cri (Tι (-π Ui M O i-P O Co ι > co --j _-. Lπ crι -π M ^ w oai u in ft ijiμ oi iiiKi ω MO αj j ω jM fc μ ω m N o φ Ui ω fc oi ω uΛ o ω ij u oWib ω oi l i iD μM NjA M μ J Λ ω iD tn i iD m o ' --J σ .i^ cr> ω ω !Tι o cfl U3 σi d-. ω Q M un ι!-. crι θ un -J M ω o to co uι oi iu ιi- ciι μ i M ϋι,iB -j cιι ( Λ ω w -4 ifl θ) Nj oω ιo iJ u) m y ivj o o w μ ιi- m iJ iD fc ^j μ -J cΛ θ M ω o ^ M i m si (j\ o iD θ ii) ci) vi m μ cιι M M M M M M M M M M M M M MMMMMMMMMMMMMMMMM M M M M M M M μμμμμμ oσσoooσooσoooooσooooooooooooooooooooooooooσooσooooooooooooooo oooooooooooooooσooooooooooooσoooooooooooooσoooooooooooσoooooo ω w o m o o μ o o j σi O j j u g iD iD μ o io ui is o N a oi w N ^ m io iD Ui J- μ oo o σi w tD μ j ω M tti μ μ ib ui ui co ω co o oi i- μ o M i- co cn co σi cn --J σι rι cn ciN D c^ cΛ -^ ∞ θ crι σι ^ Λ cϊN cn co m Ω Ω O Ω Ω a Ω O Ω Ω O Ω Ω a O O Ω O Ω Ω Ω Ω O Ω Ω a Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω a O Ω Ω a O O Ω O Ω Ω a a Ω Ω Ω Ω O Ω Ω a Ω Ω pa pa pa pa pa pa a pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa 4 β H β H μ - H i-- - H i-3 H- - - t-- - μ - >-- ooooooooooooooooooσoooooooooooooooooooooooo o o o o o ooooooooooooo 2232222222222222222223232222222222222222222 22222 2222222322222 M . M , M , M ■ • I-' H I- J I- J I-' !--' I- 1 I-' (jϋ i ω i ω ijj ω ω ω ij ω ω ω Lυ ω ω ω oj ijj υj uJ L ϋo ω CO tO O lO U3 ω i_D CO ∞ ∞ ∞ OT ∞ ∞ ∞ ∞ ∞ ∞ -J ^ -J --J -J --J --J --J -J ^ σι Ul ^ ω M O 300 -- cn Jl -^ Cϋ O D 03 -- cri Λ *» ω O CD X) ^ crι l -^ ω O CO Ωpaa0Ω pΩaaΩtJ OΩΩpaaΩtHOΩΩ3ΩOΩσΩΩOtB0Ω pΩaaΩDΩDΩQΩtj)O0 p0aaaσ0OΩΩΩtfl0Ω0paaaσ0OΩΩΩtB0OΩpaaaHΩHθOaOΩΩΩtDOΩΩpaa0M0HOO M M M M M M M M M M M M M M Ω Ω Ω Ω Ω |P s pa pa p p pa M M M M M M M i→ M M ^ M M ^ tr 1 tr* f tr 1 tr 1 ft EH f iH f f tr' iH ra ir' f M M M Kl H M M H K M W M K M ^ αα ι-<; ap pa a ap ρ G αGGG σ G σα σ Gσ α Gα σa a zaa 3 a ω coω w co c ω ωωωσ αα pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa . a pa pa pa pa pa pa pa pa pa pa 1 l-^ ÷ \-> \- - i ^ ^ ^ i--' t-' l^ -' * l--' ^ l^ h-' h-> ^ i-^ l- H' t-- t- i t-- 1 l--' l- i -> M. M M MMMM M MM MMMM MMM M MMMMM MM MMMM MM o o D Uj ω cj oo co co co ∞ -j ^ ^ ^ σN yi yi cn cΛ c^ σN CΛ Lπ ui ui ii i αi w CO c co CX> CO M O M (-O M W OJ W (jn il-. >l^ ai CO -J -J C^ iIi tJl cri C^ W ^ On ON ^ CΛ c ω tΛ θ M ι-» θ M ω M U3 M M C5N (yi M ---- iI-' UD iΛ u o ffi iB O Λ Ni ω M H U o o iii -J w o fr M J ω oo m Λ cn ^ r> - jι uι uι aι (jι ci n (ι ι ι /ι <^ j^ (_π Λ jι jι cι jι ui j- ^ co o o o o o .i i ω co i m ϋι aι (ji ιb iJ o u) θ μ w M μ o N w o ιo o ιo «) Ui i flι oι ^ -J ^ m m ci) i ^ a] i Λ iD «) θ θ μ » uι * M M θ ιo iD -J ∞ ∞ ∞ -J CD W O Ul --0 >I^ M W-- U3 -J 0 3 cΛ ω M O O U1 cn <-π O C0 ∞ l Λ m l_D M (Jl J CO M Un M lO O I_D M W CO M Cl -J uJ O M O <O (jJ U3 U ) uJ M CX) M J-- CX3 M CO U1 M U3 W m ιt- jJ -J CO -- M ιl^ ^ ) ι^ ^ ι CD CB CJl M --J ϋO O U> M <-^ CO ∞ C M M ^ aι c -J -J CO C^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M 0 uJ Lu W W LO LO L0 ) M W M LO U) W > lJ uJ (jJ M M M Ui a^ Ul U-. 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W M M M CX> O ∞ c C^ O M ON Cn co m l-π ljJ O OO CO cΛ Ul lo O tn cO σi Ul Oϋ ljJ CP OO M -J m o w ω μ o ^ i ϋi ^ fΛ ij ^ M μ i o ω M μ -J oi μ i ^ σi ^ ib o m ^ co j ui iii μ iji o o o m i -j mo m oi U J M M σi 'j μ m coω a iii o M J^ Ul --J O ιJ^ M ^ <-3 lO M M U7 ( ^ ^ ∞ M ai -n θ --J Cσ ω ---J ι<- ' 1 Λ U30 M -J m -J to i-> I-' -> ooooooooooσoooooooooooooooooooooooσooooσooooσoooooooooooooooo oooooooooooooooσoooooooooooooooooooooooσooooσoooooooooooooooo crι cτι -rι crι aN crι Cjι Ui σN -π cπ <-π ui Lπ Lπ crι υi (_π tji.ui un θi (_π uπ cΛ cn σ Ui σN Ui Uπ <_^ CΛ σ> cn cr> Λ Λ σ^ σι Λ C ιi- j- iD Ciι J- w -J U) θ tD (J θ ιi- ) ω iιι *. ιi- *> ω L<) ij) ιi- μ o μ βi θ J a) W i (D ~J uι f ω t M ω μ μ o μ μ uj aKjKri i i ffi oi o -J.cn M ii- σi ib oμ ^M -i J -J o o u) vi j o ω o M m w J j o w * ιo o ft (S H ω μ ιi) {jι uι ω uι u o co uι u ii) i μ ω iD J (ιι o ω iΛ ^ Λ in iD Ui ffl (iι t> cn (jJ ON CO (3N O ON CD cyi D O -J --J com fc θ Ni co ω ^ vi co m -J M θ (- ιt. u ^ co ιιι * ' W U (Jι ^ μ Ui M i- μ (rι θ uι t ω tJ Ui *. i uι *, ijι uι , -j ∞ σN yι ---- σι i ) crι cjι --J crι oa crι crι -J cΛ Λ θ^ σι co yι σN ^ c^ crι Ω a θ Ω Ω a Ω O Ω Ω a Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω a a θ Ω Ω O Ω Ω a a θ Ω Ω O Ω Ω Z a θ Ω 2 Ω Ω O O Ω a θ O Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa a pa pa pa pa pa pa OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222222222222223233332322222222222222222222222322222 M M M M M M M M M M M M M M M M M M M M M M M M t- , i-' t-* i-> H 1 -> >-' t-' )-' l-' l-' t-' U-. lI-. „_. tfc_ il-» Ji. lE- t . tC- 4-. i . -i» (jO GJ ω ω ω ω M N N M M ω M M N M H μ μ μ μ μ μ o o o o o o o o o o ω M ΩΩ O ΩΩ a ΩΩ Ω ΩΩΩΩOΩΩa O O ΩΩ Ω O Ω Ω to pa N H H D D O W pa H tS O Ω tB M M M M M M M lr 1 lr' t7 1 f pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ' pa pa pa pa pa pa pa pa a' pa pa pa p^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ∞ OO ∞ CO ∞ ∞ ∞ CO OO OO OO ∞ ∞ ∞ OO CO CO ∞ ro CO ∞ OO CO CO ∞ CO CD ∞ CO ∞ --j -^ -j -^ ^ c σι σι o^ yι crι y> ci N crι Ui jι uι (-π uι uι (^ j-. j^ j-. j^ j-. j^ CO c CO (o ω ω ω ijJ M M M M M ω M M M ω M ijJ ijj ω ω ω ij ω ω ui ω ω ω ω CO M ω M M O (-n j^ (_π m --J l-3 CO OO CO --l --J OO O U3 O CO CJl U-l Crι --J ∞ O lD ω Ui oo oo uι ω ω α^ j^ » o --J Ui ιi^ π oo o crι Cfι cι l^ M ji ιi-. -j --J M ω ui o w μ i o m ^ ui a μ oi μ cή W O fc ij io w o ω iD UJ -J ω oi ^ o o a ω ω& ω u i ui w M ^ u oi io w ^ o fo i i N Bi o M ^ co m iD ui Λ C» M M M O (J10D -J ON α300 M U1 U-- O ιI-- Ul CD Ul Ul CO ) M CD (jO (Jl M C51 -n CJl M M M IjO m co Uι uι uι ω w ϋi ϋι αι ι i -i uι uι ιjι uι uι uι αι αι ιn _ι ω uι ui Lπ w uι uι uι uι _ι cn m σ> m ch cΛ ω ω oo.ω -. Λ ~^ un »^ ω ω M^ ij ι ι cD ci3 (-π crι --J ∞ co -j ∞ m ^ oi m ω o ui ui M ^ co M Λ W i μ ui fc co w αi ij i ∞ o ui fc o m tύ ^ μ ^ m μ μ ra oi M ω m i mO i μ o μ o -J Ui ui io oJ o ω M w co m o -J -o o o ω o u3 --J --J Ui M cτι M ω co υ3 M U3 θo ω --J M --J θ (j π u ) U ) --J co ( j o ^ co o^ M.o -J -J cfι μ co ω μ j M oι *, σι θ cΛ θ μ μ cfi σι iΛ M -J iii ui ω ∞ ϋi ω M H io ui iB oi O M oi μ i U tB M co j is o M w fc ^ -j μ i μ ϋi μ o u Φ Ui l μ w j iD O io o o -J oi ω ij Ni co i c (jj cυ ω oo ω ω ω ω ω ω ω ω ω ω ω ω oj co u ω M W (jJ ) ) (j0 W (jJ (J -^ (Jl J-- i (Jl iI- W cn ^ (Jl Ul J-- C0 3 O O M ) uJ M m oo M u3 ) co M ( jo ω uι σ^ M oo (j j ω -. co c M -^ c^ J j ^ crι σι θ θ M M ci3 M uι o o oo o crι ∞ to M Ul M ∞ (jJ ι^ O ιl^ O CD ^ M --J ω --J O M M M C ω --J -J CD ^ O --J ^ M M -n Ji ω ∞ ιJ^ CO M --^ 01 CT) Jl ) _n U100 U) Ul ∞ W M Lπ >fe 3 ω ω <-π M ω co ^ M O M Ul Iβ Ul U) 01 --J M -J -^ i-> t- 1 l- 1 I- 1 h-> l-> >-' - i l- i l- i l-' >-> )-' t-' l- Λ MO OOOMM M MMMMM MM MMMMMMMMM M M M M M MM ooooooooooooooooooooooooooooooσooooooooσooooooooooooooooooooo O OOO OO O O OOOOOO O OOO OO O O OO O O OO O O OOOOOOOO OOOOOOOO O OO O O O OOO OOO OO O cβ ω ιr^ ω jι ω -- ' iϋ θ c-3 υ3 M i Lo ω ιfc rι ) J CjJ ui (_n ϋι ji ιi-. ϋJ Lϋ -^ Ifl tD vj *. -J M M ( -0 CX5 M M 0-- 03 M a^ ∞ M M M M CJ C0 ( J Ul C0 U3 ω σ θ O θ m lΛ M M crι I M Uπ --J M σι ^ M CJl CXI 00 CD M θ ω M J^ -^ ∞ jμω g *w jo> i*aiMmωwiflmoooooo JUiiowθ Jθsiιni θ iμo3 MMaι*o πuι*μ-)θjμo wιoμuιμw cτι oo en Λ -J oo ∞ m ^ σN ∞ cn ri -J σi σi σϊ Cq c^ m - j -J σi Λ cri σi Oo c 00 Ω Ωa 000 ΩΩ 000 a 0 0000 a a Ω Ω Ω Ω0 Ω020 Ω 0 Ω Ωa 0 Ω Ω 00Ω aΩ 0000 Ω Ω 00 Ω 2000 Ω Ω 00 papapa pa pa pa'pa a pa pa pa pa pa pa pa pa pa pa pa pa pa pa p a pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ H ι-- μ - - μ _ - H H μ 3 _ H H μ_ H H i-_ 3 H μ 3 »-3 H H H H μ 3 H !-3 H H H H t-a H - μ 3 H _ H H H OOOOOO ' OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222233222222222222222322222322222222222222222222222223222 I-'MMMM ω l H θ U) O O a Ω Ω Ω Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω aaoΩΩoooa ΩΩΩΩΩΩΩOΩΩaOOOΩOΩΩaaOΩΩΩO Ω Ω 3 Ω Ω Ω O Ω Ω pa σ Ω Ω tO- pa O Ω Ω tD pa o o Ω ω pa NKHdDOtB pa σOΩtU pa WWOΩCO pa N W H D D Ω M M M M M M M M - MMMM MM MM ■ M Ω Ω Ω H H M H H W H H H M M M H H H pJpa pa pa pa pa,pa pa iτ) tτ3 fo iτ) iχ) 3 rα 3 3 3 W pa p pa p pa θ Q θ Ω Ω Ω Ω ^ | τ) ^ ^ O iτ) Ir'f rr'tr'f rr'-tr'f tr'fr't-'l'. f ir'tr'Ir'I'I'I'coωωcQωω G G G M M M H W W ta H M H W M M H t^ M a a a a H W M M M M papa pa pa pa pa pa pa pa papa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M d^ >fe -^ W W C W Cjd (_J UJ W M M M M M M M M M M M M M M O O O O O O O O O O O CP U3 3 CO lD i jD tn i!) 73 M M M M ω ) M M ω ω ω u> ω M ω ) (^ α) ω U) θj ω ω ω <J θ ω Λ c M ^ >fc ( -n -. cn U1 ^ ( -π C^ --J M OO O CD CO C ) CO O O M M β O M M M ω CjO M M ) (jJ ω Ul O U3 m Λ M --J ∞ M >^ Ul J-. M M M ιJ^ -J Ul 3 CO W (Jl ∞ C^ M --J o --- O cr> O Ul M ω θ M ) 3 σ ---i o co ιt-. cχj u5 ιi-> cx) U) Co c orι i 4 3 θ ^ ^ ϋi ιβ» w ω oi σ ∞ m ---j ιfe to c^ ∞ ϋo σ^ y> o3 Cj i-π co ^ uι M M M J^ £) M σN -o uι cD θ c ω cn oo -^ o σι- CJ U) -^ o ^ t-' i-' l-' t-' h-' l-' i-' ' (_ ■ l_ι (_ι - M M MMMMM OOOMMMMMMM MMMM M M M M M M oooooσoooooooooooooooooooooooσoooooooooooo o,o ooooooooσooooooo oooooσooooooooooooooooooooooooooooooooooooooooooooooooooooooo ( Λm∞^ μiJiuιoωiΛσι ωω(iιoωrao oι ^fcoμo -i-Jι-(j u *.fcUιijια) ωo ιϋι ιμμμoo μμ θϊ)Wio -) i(ji i [i)o tj) crι CDMW l_D M M M ω υi ω M O O O C» M Jw ioui M iφφa -iMαioooμw ^ fco iJifrw oiμuoco^ -iωwui- m Λ - J Λ Λ σi σN ro cΛ y i - J c^ cΛ cΛ Λ ∞ σϊ C Λ - J - J co cr o^ Ω Ω a Ω Ω Ω Ω O Ω Ω a O Ω Ω Ω O O Ω a a O Ω Ω O O Ω a Ω Ω O O O Ω Ω O O O a O O O O O O Ω a a O O Ω Ω O O O ≥I Ω Ω Ω O O Ω ATOM 1520 O GLU A 194 40.003 57.132 21.950 1.00 66.30 8 O ATOM 1521 CB GLU A 194 39 .892 58 .291 24 .637 1.00 68 .66 6 C ATOM 1522 CG GLU A 194 39 .800 57 .934 26 .157 0.00 25 .00 ' 6 C ATOM 1523 CD GLU A 194 40 .848 58 .903 26 .668 0.00 25 .00 6 C ATOM 1524 OE1 GLU A 194 41 .713 59 .320 25 .870 0.00 25 .00 8 O ATOM 1525 OE2 GLU A 194 40 .802 59 .247 27 .869 0.00 25 .00 8 O ATOM 1526 N ILE A 195 37 .702 57 .319 22 .136 1.00 61 .00 7 N ATOM 1527 CA ILE A 195 37 .961 57 .195 20 .696 1.00 60 .90 6 C ATOM 1528 C ILE A 195 37 .914 58 .612 20 .207 1.00 61 .82 6 C ATOM 1529 O ILE A 195 36 .943 59 .242 20 .576 1.00 64 .02 8 O ATOM 1530 CB ILE A 195 37 .155 56 .016 20 .185 1.00 58 .85 6 C ATOM 1531 CGI ILE A 195 37 .607 54 . ' 644 20 .670 1.00 58 .74 6 C ATOM 1532 CG2 ILE A 195 37 .224 56 .122 18 .680 1.00 54 .89 6 C ATOM 1533 CD1 ILE A 195 39 .069 54 .274 20 .582 1.00 57 .69 ■ 6 C ATOM 1534 N PRO A 196 38 .923 59 .017 19 .467 1.00 61 .34 7 N ATOM 1535 CA PRO A 196 38 .980 60 .333 18 .885 1.00 63 .28 6 C ATOM 1536 C PRO A 196 37 .769 60 .521 17 .977 1.00 65 .53 6 C ATOM 1537 O PRO A 196- 37 .455 59 .613 17 .211 1.00 66 .74 8 O ATOM 1538 CB PRO A 196 • 40 .213 60 .261 17 .991 1.00 62 .20 6 C ATOM 1539 CG PRO A 196 41 .062 59 .159 18 .542 1.00 62 .55 6 C ATOM 1540 CD PRO A 196 40 .080 58 .167 19 .078 1.00 61 .87 6 C ATOM 1541 N GLU A 197 37 .072 61 .644 17 .969 1.00 65 .81 7 N ATOM 1542 CA GLU A 197 35 .896 61 .787 17 .120 1.00 65 .73 6 C ATOM 1543 C GLU A 197 36 .151 61 .579 15 .646 1.00 64 .55 6 C ATOM 1544 O GLU A 197 35 .227 61 .107 14 .943 1.00 61 .75 8 O ATOM 1545 CB GLU A 197 35 .196 63 .134 17, .332 1.00 67, .28 6 C ATOM 1546 CG GLU A 197 34 .012 63 .405 16 .579 0.00 25 .00 6 C ATOM . 1547 CD GLU A 197 33. .455 64, .799 16. .789 0.00 25, .00 6 c ATOM 1548 OE1 GLU A 197 34, .083 65. .585 17. .529 0.00 25. .00 8 0 ATOM 1549 OE2 GLU A 197 32. .390 65, .106 16. .213 0.00 25. .00 8 0 ATOM 1550 N GLU A 198 37. ,361 61, .843 15. ,117 1.00 64. .29 7 N ATOM 1551 CA GLU A 198 37, .547 61, .575 13. .666 1.00 63. .21 6 C ATOM- 1552 C GLU A 198 37, .470 60, .048 13. .500 1.00 62, .44 6 C ATOM 1553 O GLU A 198 37. .082 59. .632 12. .414 1.00 64. .04 8 O ATOM 1554 CB GLU A 198 38. ,736 62. .257 13. ,017 1.00 63. ,11 6 C ATOM 1555 CG GLU A 198 38. .854 63. .560 12. ,947 0.00 25. ,00 6 c ATOM 1556 CD GLU A 198 39. ,673 64. ,083 14. ,088 0.00 25. 00 6 c ATOM 1557 .OE1 GLU A 198 40. ,184 63, ,247 14. ,864 0.00 25. 00 8 0 ATOM 1558 OE2- GLU A 198 39. ,805 65. ,311 14. ,210 0.00 25. ,00 8 0 ATOM 1559 N GLU A 199 37. 756 59. .250 14. 520 1.00 59. 04 7 N ATOM 1560 CA GLU A 199 37. ,674 57. .812 14. 540 .1.00 57. 74 6 C ATOM 1561 C GLU A 199 36. ,488 57. ,305 15. 363 1.00 55. 26, 6 C ATOM 1562 O GLU A 199 36. 479 56. 229 15. 959 1.00 55. 68 8 ' O ATOM 1563 CB GLU A 199 39. 028 57. ,276 15. 092 1.00 58. 08 6 ■ C ATOM 1564 CG GLU A 199 40. 197 57. 343 14. 110 1.00 61. 18 6 C ATOM 1565 CD GLU A 199 41. 375 56. 461 14. 504 1.00 65. 23 -6 C ATOM 1566 OE1 GLU A 199 41. 460 55. 614 15. 464 1.00 66. 14 8 0 ATOM 1567 OE2 GLU A 199 42. 416 56. 576 13. 786 1.00 66. 97 8 0 ATOM 1568 N SER A 200 35. 380 57. 990 15. 534 1.00 54. 20 7 N ATOM 1569 CA SER A 200 34. 264 51 . ' 468 16. 356 1.00 ' 55. 68 6 C ATOM 1570 ,C SER A 200 33. 771 56. 124 15. 822 1.00 55. 37 6 C ATOM 1571 O SER A 200 33. 535 55. 163 16. 607 1.00 57. 10 8 O ATOM 1572 CB SER A 200 33. 190 58. 510 16. 625 1.00 57. 62 6 C ATOM 1573 OG SER A 200 32. 422 58. 898 15. 481 1.00 59. 81 8 0 ATOM 1574 N , .TYR A 201 33. 658 55. 870 14. 514 1.00 51. 39 7 N ATOM 1575 CA TYR A -201 33. 289 54. 536 14. 053 1.00 49. 13 6 C ATOM 1576 C TYR A 201 34. 050 53. 411 14. 734 1.00 46. 41 6 C ATOM 1577 O TYR A 201 33. 471 52. 361 15. 033 1.00 46. 32 8 O ATOM 1578 CB •TYR A 201 33. 376 54. 384 12. 536 1.00 48. 20 6 C , ATOM 1579 CG TYR A 201 32. 801 53. 150 11. 864 1.00 48. 31 6 C ATOM . 1580 CD1 TYR A 201 31. 446 52. 833 11. 909 1.00 46. 03 6 C (56 • I m 1 l.lllb'-.ll ATOM 1581 CD2 TYR A 201 33 .634 52 .271 11 .160 1 .00 47 .27 6 C ATOM 1582 CE1 TYR A 201 30 .930 51 .717 11 .299 1 .00 44 . " 02 6 c ATOM 1583 CE2 TYR A 201 33 .144 51 .146 10 .537 1 .00 44 .47 6 c ATOM 1584 CZ TYR A 201 31 .789 5.0 .868 10 .609 1 .00 44 .31 6 c ATOM 1585 OH TYR A 201 31 .315 49 .730 9 .978 1 .00 39 .36 8 0 ATOM 1586 N ALA A 202 35 .328 53 .475 15 .027 1 .00 47 .02 7 N ATOM 1587 CA ALA A 202 36 .133 52 .427 15 .653 1 .00 44 .43 6 C ATOM 1588 C ALA A 202 35 .733 52 .107 17 .047 1 .00 46 .51 6 C ATOM 1589 O ALA A 202 36, .293 51, .210 17 .667 1 .00 50 .94 8 O ATOM 1590 CB ALA A 202 37, .602 52 .780 15 .673 1 .00 42 .28 6 C ATOM 1591 N ALA A 203 34. .760 52, .749 17 .670 1 .00 47 .90 7 N ATOM 1592 CA ALA A 203 34 .361 52 .380 19 .018 1 .00 47 .87 6 C ATOM 1593 C ALA A 203 33, .633 51, .040 19 .009 1 .00 47 .45 6 C ATOM 1594 O ALA A 203 33 .381 50, .381 20 .034 1 .00 49 .50 8 O ATOM 1595 CB ALA A 203 33, .475 53, .542 19 .470 1 .00 49 .39 6 c ATOM 1596 N ASN A 204 33, .235 50, .554 17 .852 1, .00 45 .04 7 N ATOM 1597 CA ASN A 204 32, .473 49. .314 17 .661 1, .00 43, .05 6 C ATOM 1598 C ASN A 204 33, .456 48, .263 17 .188 1, .00 41 .25 6 C ATOM 1599 O ASN A 204 33, .818 48, .134 16 .021 1, .00 41, .10 8 O ATOM 1600 CB ASN A 204 31, .261 49. .579 16, .784 1, .00 41, .59 6 C ATOM 1601 CG ASN A 204 30. ,545 48. .426 16, .175 1. .00 45. .98 6 C ATOM 1602 OD1 ASN A 204 30, .765 47. .242 16, .492 1, .00 49, .13 8 O ATOM 1603 ND2 ASN A 204 29, .603 48, .565 15 .223 1, .00 47, .73 - 7 N ATOM 1604 N CYS A 205 33, .955 47, .488 18 .127 1, .00 36, .51 7 N ATOM 1605 CA CYS A 205 34, .986 46. .'521 17 .788 1, .00 33, .94 6 C ATOM 1606 C CYS A 205 34, .516 45. .291 18, .543 1, .00 35, .73 6 C ATOM ' 1607 O CYS A 205 33. .765 45. ,586 19, .453 1, .00 34. .23 8 O ATOM 1608 CB CYS A 205 36. .284 47. .042 18, .458 1. ,00 32. .65 6 C ATOM 1609 SG CYS A 205 37, .001 48, .237 17, .296 1. .00 40. ,44 16 S ATOM 1610 N ILE A 206 35. .002 44. .096 18, .233 1. .00 34. .95 7 N ATOM' 1611 CA ILE A 206 34. .522 43. .018 19. .095 1. .00 32. .63 6 C ATOM 1612 C ILE A 206 35. .711- 42. ,189 19. .578 1. ,00 33. ,52 6 C ATOM 1613 O ILE A 206 36. .687 42. .130 18, .864 1. .00 35. .63 • 8 O ATOM 1614 CB ILE A 206 33, .633 42. .078 18. .349 1. ,00 31. ,19 • • 6 C ATOM 1615 CGI ILE A 206 34. .233 41. .870 16. .952 1. ,00 28. ,33 6 C ATOM 1616 CG2 ILE A 206 32. .175 42. .449 18, .289 1. .00 32, .94 6 C ATOM 1617 CD1 ILE A 206 33. .674 40. .537 16. .426 1. ,00 32. .06 6 C ATOM 1618 N TRP A 207 35, ,544 41. .663 20. .776 1. ,00 33. ,42 7 N ATOM 1619 CA TRP A 207 36. ,530 40. ,895 21. .417 1. ,00 34. ,40 6 C ATOM 1620 C TRP A 207 36. ,245 39. ,445 21. ,077 1. .00 36. ,42 6 C ATOM 1621 O . TRP A 207 35. ,087 ' 39, ,046 21. .243 1. ,00 35. ,39 8 O ATOM 1622 CB TRP A 207 36, ,366 4.1. ,069 22. ,947 1. 00 33. 30 6 C ATOM 1623 CG TRP A 207 37. ,287 40. 108 23. ,700 1. 00 30. 66 6 C ATOM 1624 CD1 TRP A 207 38, ,602 40. ,405 23. ,942 1. 00 29. 27 6 C ATOM 1625 CD2 TRP A 207 36. ,989 38. ,838 24, ,240 1. 00 27. 00 6 c ATOM 1626 NE1 TRP A 207 39, ,089 39. ,323 24. ,629 1. ,00 31. ,52 7 N ATOM 1627 CE2 TRP A 207 38. ,171 38. ,360 24, ,835 1. 00 26. 28 6 C ATOM 1628 CE3 TRP A 207 35, ,847 38. :032 24. ,303 1. 00- 28. ,27 6 C ATOM 1629 CZ2 TRP A 207 38. ,286 37. ,153 25. ,465 1. 00' 26. 07 6 C ATOM 1630 CZ3 TRP A 207 35. ,961 36. 773 24. ,966 1. 00 29. 27 6 C ATOM 1631 CH2 TRP A 207 37. ,180 36. 344 25. ,536 1. 00 28. 64 6 C ATOM 1632 N VAL A 208 37. ,213 38. ,628 20. ,651 1. 00 36. 26 7 N ATOM 1633 CA ,VAL A 208 36. ,693 37. ,227 20. .461 1. 00 35. 78 6 ' C ATOM 1634 C VAL A 208 37. 876 36. 354 20. 885 1. 00 33. 79 6 C ATOM 1635 O VAL A ' 208 38. ,794 36. ,416 20. ,062 1. 00 33. 39 8 O ATOM 1636 CB VAL A 208 36. ,261 36. 772 19. 046 1. 00 35. 18 6 C ATOM 1637 CGI VAL A 208 35. ,753 35. ,309 19. ,030 1. 00 28. 30 . . 6 C ATOM 1638 CG2 VAL A 208 35. 147 37. 646 18. 498 1. 00 35. 67 6 C ATOM 1639 N ASN A 209 37. ,776 35. 707 22. 019 1. 00 34. 60 .7 N ATOM 1640 CA ASN A 209 38. 919 34. 880 22. 401 1. 00 36. 57 6 C ATOM 1641 C ASN A 209 40. 254 35. 569 22. 360 1. 00 36. 26 6 c pa pa pa pa pa pa pa pa pa p> pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ta H μ - H ι-- - i-- - H μ - '^ H H !-- μ - i-- - H H μ - H μ - H t-3 H i-3 H3 i-3 μ _ H- μ 3 i-3 μ - H μ - μ 3 >^ OOOOOOOOOOOOOOOOOOOO O'O OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222222222222222222222222222222222233332332222222222 l_ ι |_ i |_i |_. l -- l _- l _ ι l _. I-> M M M M M M M M M M M M M M M M M M M M M M M M M M M M -J --J --J c^ crι σ CΛ cn O O O l_3 Cø C Q <£> l£> M 01£> CX> --J c Ol OJ Ω O Ω Ω a Ω Ω Ω O Ω Ω a Ω - O O O O Ω Ω Ω Ω O O Ω Ω a Ω Ω O O Ω Ω aa ΩsoΩΩOΩo O O Ω Ω Ω O Ω Ω a a o Ω Ω o CO pa D Q D- p pj D Ω -0 pa O Ω Ω to pa Ω Ω tjO pa K W N H D O ffl ! H M O CI B pa D D Ω-ω M M M M M M M M M M M Ω ^ Ja H) H) lti 'fl lfl lT) ' S lS g g g S g g H H H H H H M H < < < < < pa pa pa pa pa pa pa pa pa pa o O Q Ω Ω Ω Ω Ω Ω pa pa pa pa pa tr 1 t i f i t t t l 'S 5cl fO !a ii) ?l ! M H IS B H H H M t < t , t< lr' f f tr' t-' pa pa pa pa pa pa pa jjd ^ " o |xi ^ ^ « ^ ^ ^ |r , f tr , lr' tr l t tr , t- | t | c c . ai co K pa ?a pa pa pa O O O O O O O ι-- i -3 ι-3 μ - μ - μ 3 !-3 H_ W H M M M H H tS t- , t t l EH tr 1 tr 1 HΩ -ΩΩΩ ΩΩΩΩΩΩGσσσαGGGG aaa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMOOOOO ^ Λ <Jι m m σι uι w w (Λ -i w i Λ * * ^ Λ Λ ^ ^ ω ) ω Lo ω ω u ω M M M N W M M μ μ H μ μ H μ H μ μ μ o o o o o o o o o iϋ «3 co iD CO c CO CO ^ Λ u α- ^ ω ω ω ω w ω ω ωι-. Λ ^ u ω ω ω ω ω ω ω ω ω u ω u u ω k ^ ω ω fc ^ ι-. ι-. fc ιt ^ -ι ω ι^ ι-> fc ii- fc * j- -. j-. it. it-. α^ io co o J J-- o ιo o o tD m uι σι ω αι m ~J o μ o (- αι -j -j co i (rι ^ vi oι ι -J ∞ «) -) θ cι u) io o μ M M ( jo μ ιo o μ μ M M Ul M M O -J CTl -— I CO M ui μ o o m u -j o -i Φ O i iΛ U φ μ -j ^ o Ni ω ω o w fe iD U a ω μ m ui -J -J ∞ i w μ M u iD ib Ui oi w u iΛ -J NJ j μ o ffi ω μ i- iJi ∞ μ co cn ω co ι uι co o ω M o ω c^ σι M ∞ oo o cβ ∞ o cr> >^ ca ∞ c^ ∞ M ^ M 01 ( CTl M CO O M M M CΛ M O ι^ -J crι -J ) ^ O CO O M M CΛ --0 -J --J CO M OO U5 M cn -J (J U1 CO CX) 0 ∞ m >I^ M M ω --. ) M M M M M M ω ^ Ch O O C -J θ O crι Ul W U1 C» M M M M M μ u ω ui *. Λ Ul M σl UI MMMMMMMMMMMM M M M M M MMMMMMMMMMMMMMMMOOOOMMMM MMMM ooooooooooooooooooooooooooooooooooooooooσooσooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ui ιi- ιi- frifc fe U u ω ^ Λ 4- U fc fc ι-. fc lJ iιj ^ fe U ) U (j ( j ιi- ω u ω Λ C j -j w u ω Λ ω ω ιb _) u ^ M ω σ N ∞ Fϊ ιfe ∞ u-ι ^ cβ (jθ M CD θ c^ M ιi^ θ3 i£> o o σι ' --J co co o cα σ^ Cj ft A O i ω ω cfl ^cn oJ W∞ w u σi -J O ^ ω M ω ui ui o ui ω iΛ ii- fc σi m M μ ω m μ μ i tii μ J W Jo μ o o o o μ ^ ui ui u oi cn ∞ O CO M M CO Lπ O M CO CO CΪN CO --' CO O CO O O UJ I£> C0 θ ω σN M cn M C ω M .-- O C-3 ιfc M crι >(^ O tJl M M U> crϊ U1 O O O O M M -J C Co cn cn ^ cri cΛ σι ϊ ) σ^ crι --J cn ri Λ yι co cn cΛ ^ cΛ σN cri CΛ aΩooo oΩΩOΩ a ω oooo oΩO oo Ω ooΩΩaaa ΩΩ oo oooΩΩOoo ooΩO pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p ι-- i-3 i-- H H t^ μ - - _ H μ - H- β >-- μ H H H H μ - H H - H H μ - H ι-3 H f^ H i- >-- H i^ ι-. H '-- H μ - H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 3222222222222222222222222222222222233222322222222222222222222 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM --J-J~4-J-J-J-J-J-J----^--J--J--J-J-J-J^-J^-- -J-J-J-J-J-J-J.-J _N σι m m ϋi w iJi uι ui -π _n uι w iji ιb ^ fc Λ ιb -- ιb ^ ιfc. ^ w ω ω ω ω ω ω ω ω ω M M W w w w M i Ni μ oio o si m ui ^ ω wμ o iD ∞ i oi ui fc U M μ o uiω j m ui fc ijύ M μ o io ∞ -Jmui ^ U M o a ∞ i iji Ui ^ u w μ o io tD j iji ui ^ u a O O Ω Ω Ω O Ω Ω -3 a Ω Ω O Ω Ω aΩooooΩaaaoaΩoooooaΩΩΩo ΩΩaOΩΩOΩΩΩΩOΩΩaOΩΩ H H D O W -p S S N H O O tB pa Ω Ω CO pa W W N H D Ω CO pa O Ω tfl pa WNHHODQW pa pa M M M M M M M M M tr 1 Ω Ω Ω Ω Ω Ω Q'O Ω p pa a a pa a pa H_ H ι-- H μ - 3 3 a pa a a pa a pa p pa rtf ^ rα w ' -ι 3 a μ3 3 μ _ tr < t- , lr< tr l t-' lr' t d t- , tr l wασασαασασ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω |Λ pd ?) ?O pα i I Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω O O O O O O O ?3 pO pO ?- ?0 ?O JO Ϊ]d ?d !Λ ?O ϊ)α ι-< κ; κ pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ MMMMM M-MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM O-.LuljJW-JW(-dOJ<jJtA> M MMMM MMMM MMMOOOOOOOOOOOC0(i3 3COl0 CO c CO ,j_. uι α-. uι α^ ,ι_ ' ti^ 4-. d^ ι ϊ-. ιi^ α-. l ι^ α-. α-. α^ α-. ,fe α^ ιi-. ^ CO uι o cβ θ u) ∞ -j cr! -J cτι U3 D ∞ -^ σι <-π !t-. uι <-π ιi^ ω o o o ω ∞ oD co o o tJ M oo >j^ ω ω ^ uι u-ι σ cr> cø σ> ι .f^ cr> θ M co θ LJ Co ^ ∞ σι (jJ θi -J ω M ϋJ -J -J σ --J crι α^ ^ cΛ J^ yι --J ) ϋ θθ co CD i ) co c^ σi μ m.M m ∞ O M μ mO i μ.^ iD ω co o μ u w ω uiio w ω μ ^ μ o m o ^ io ifl i M uiD ^ μ M O M ^ ω ui ^ io μ o i ω ω u μ oo J Λ Ui ON m C i un Ui ( ^ (_n ^ Ui Ui (n ui il-. ~-. u^ 4-. »^ d^ d-. 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IjJ M M O lO OO --J σN (Jl --. ω M M O CD CO --J cyι 01 J-- (j M M O CD ∞ ΩOΩΩaOΩΩΩΩΩOΩ OΩ O 2 rπ rw ffiNMMdnoni na Ωo roao π OΩπDΩΩΩΩttBoOΩo pa a S ffiΩ N B O Ω B)OΩΩ paao OΩOaOΩΩΩOOΩaaOOΩΩOOO mN M to pa OΩΩtO pa N tfl d Ω IS pa Mn M MoαMΩD- M M M M M M pa pa pa pa H H ^ μ3 H H H3 H H H Ω Ω Ω Ω Ir l tr , lr l tr' t- , t t-' t- | pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H H H M H H H |r l t- , t- 1 t t- | t- | t- 1 t- 1 w ^ ^ p iiJ ^ Hi Kl Kj ^ b l^ ^ BI H M M H H H H Jt Jll JJ ^ JJ ^ JJ ^ Ill tO P tr 1 tr< tz< tr* tr* tr* t* ft* tr* tr* < ι K K ι< t< K K Ω Ω Ω Ω Ω t ^O ^O pO ϊiO jα ^ύ pd ϊJύ ^- ϊO ^t G G G G G G σ G Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω p pa pa p H H tS tfl M M M H W W M C C C C C pa pa pa pa pa pa pa pa pa pa p3 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ' p a pa pa M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ω ω U) ω ω (O (jJ <jJ ω (-0 (j ϋJ ϋj ω ϋJ J ω M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M μ μ μ μ o o o o O QO o o o o o ω ϊJ iD i- ω αj αj o ni αi αi -i J i j i i j i j g i j oi oi oi oi oi ui ui ui ui ui i tii ui *. ^ * *. *, * *. ^ CO c CO ,I_. ,I_. CO crι ω w ω ιi- ω ω ω J- J- m it- tn 0 --J ∞ » d^ cθ σ) M O O CTl Ui ω -J Ui >fc ∞ ω Ul O ∞ θ ω m co to ι p- j-.. 1 fc.4-. --. Λ α-. ^ ιi- ' -^ J- ' iJ^ -- ' ii^ ^ ιi- ' -^ ιi-. *, α-. ^ α^ ιi-. ιj^ ιi-. j-. ^ ^ ∞ o M θ o ω ω α^ J-- M ) M M M M θ ω ιi-. oo c]o cα σ^ ^ '(-. rι --J ιfe >ι^ ^ M θ fl σι --j oo OT m * o u ^ ^ * ϋι w ω o o ω m j o %ι ω o fcu t o uι o ∞ u θ i (Λ o ^ ω ιti Ui Φ u μ o M αι ιo ω ^ (j o o j oi (ΛU) N) μ J ^ ω ι- -) M m O CO U10 I-π ω oO ιl-. M 'fe M Λ ω ^ O -- C100 ^ -^ M X ) ^ ( _l cn O M fl Cn --J cn c C) U3 J-. CO Ul ιI^ M OO O (Jl CO O >fe Cπ o ω ~^ O O M ιfe ( ι ω α-. U3 > ' σ> c MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM co ^ i m ooi uifc ^ ωuiw μ iD o M iJ Uj fc ii- oi ^ iii m w ui Λ- μ ω w MiJ M U ui ^ u μ iB μ μ o o ^ oo o M μ μ oM μ μ μ μ io μ μ m o -J -J cΛ θ ^ M oi o Λ oi -) -J - i Λ - ) Λ ι^ Λ M J- ω Ln ω αi ιb U m Λ ^ ι- ' ω σι u μ ω o u) -j W M o fc ω u o M M to u w io μ μ μ fc oi Ui ' i o ui ω M iΛ μ in μ u μ j ij μ øi iji m j a M μ M j μ o m m M U ^ ^ ∞ ui iD oi o iii iD M iB μ Ki σi U μ w ji ∞ ι)^ ^ σι ιo e σ-ι ω c o ω Λ U ) c^ ∞ Lo o co o cτι --J M o cD G^ ∞ M M M M M M i i- Λ l-' -> t- 1 - i i-' t- > t- )- i l- i t-> t-' -' MMOOOOOOMMM M M M M M MMMMMMOOOOMMM ooooooooooooooooooooooooooooooooooσoooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooσooooooooooooσ LΠ ( JI ui cn oι ϋi ϋι uι 5N Ui crι θι αι cn tJi -π 3N σN CΛ θ^ ό σN cyι crι c cn cn cΛ C cr> ω o ιt - .ι- » ! -3 co iβ θ i £ i o co cs M ∞ i D θ U i J ^ c^ j ι σN ∞ cΛ -^ ^ ^ iD μ ω ω ui ra w U -i ui iB O ^ -i co -i o ui ii- i co ^ αi fl μ n ^ o o o o o o m μ μ m μ ui N μ o cD oi fe ui fc αi ij o o o o i ui M -) iλ) oι μ ui (Λ W ∞ o oι * μ o ^ j (s * uι ιo u μ u ^ ^ -i -J fc u o o o o o o o M ffl m M iA) ffi i>) ^ μ co ιo () U M (iι ^ uι ιo o o o o -J U) (i\ αι cri Oo cyi cn ^ ∞ cn cri σi c n σi co c -n ^ o cri c ^ c cn cri cn ∞ Ω O O Ω a O O Ω O O Ω Ω Ω O O Ω a O O O a O Ω Ω O O O O a Z a Ω a Ω Ω Ω O O Ω a Ω O Ω Ω a Ω Ω Ω Ω O O Ω a a Ω Ω Ω Ω O Ω O pa pa pa pa pa pa pa pa pa pa pa pa p3 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ H»3ι3HH«^ 3^ ι3βi3^H H3^«H^rt rtHH3ι3^^^ ι3^H4^^β^^^H 4β^ ^β^ι3^HHH^Hι3^HH OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222222222222222222222222222- 222222222222222322223222 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O3 O0 OD CO CO O3 O3 O3 ∞ O3 CO Ci0 C» CX> C0 C000 O0 CO CO O3 CO ∞ ∞ C0 O3 O0 CO O0 ∞ cα co Go α3 co -o --j ^ ^ -j -j --j ^ --j --j --j σ^ cn σN c crι cn c n o^ c^ Ul i(-- ljJ M M O lO CO ^ c Un ~^ > M O CD CO --J cn U1 ^ W M M O C> O -J cn U^ ΩΩaOΩOΩΩaΩOΩOΩΩaOOΩΩO OOaOΩΩOΩΩ aOOΩΩΩOΩΩaΩΩΩΩOOΩaΩΩΩOΩΩaaaΩaΩΩ pa ΩtO pa ΩΩtO pa σOΩtO pa Ω Ω to pa HHDOM pa OΩΩtO pa QΩtO pa Hi ffi tsi M O Ω M M MM M M MM MMM MM MM Ω Ω Ω C0 CΛ ω ω ω ω ι^ H H μ 3 μ 3 3 H pa pa pa <; <! <; Q (π crι Ω Ω Ω Ω M H H H M H M H < < < pa pa pa pa pa ir l ir , i l H H M ra M H P |- m m |i! p ffi ω c ω |0 JM JO ?0 fO G σ G !Λ ^ W ^ ^ ^ pa ^ !Λ ^ ^ ^ ^ ιχ) 3 ^ϋ 3 ^^3 ^J l ^3 lτl t^ , t l^ , t- , t- , q α ciQα α G G α tfl M HM HHH H f r 1 ir' t-' -' t' Ω Ω Ω Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa a ' pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa MMf MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM (jϋ ω ω ω ω oj ω ω ω ω ω j ω ω ijj ω oJ ϋ ij ω ω u) CD U3 ∞ ∞ ∞ co co co --j --j --J ^ -J --J -J crι crι c^ crι σ-ι c^ cn c^ uι uι uι c^ CO c CO M ω oo ω ω ω ω Lo ω ω ω ω ω ω ω ω o ijj ijo ω ω o ω ω ω CO ca o M ijj ω o M ) Lu ϋJ J M M M ijθ -. -o σN --j --j ^ uπ -^ -o cn cn -J Λ -J ) CD Ui L^ αi ω w m ω io iji o ^ ui co oi J ω ^ fc N μ iji Φ Ui o ui o M W io ui u μ tn ω o o o ft W i j o ^ m oi w -J J Ui ui φ iii μ μ iD M -i u i io oi M ^ μ a ui fr w oi oi ai J μ ^ i- f' ϊi o o -i iD M μ i μ Λ Bi m oi μ ui -i μ ω iji μ μ iii μ ffl O fc μ oi ui m μ u μ f. μ co ui o μ oi oi io o u ui j M m ifl o oo ii- j- LJ m μ oo w ui μ oi co co u) ^ t αι oι ∞ w oι -j i- i o o o ιo o t> o «) N (jMΛ θ mo ifl uι o ιιι m U i cn co.oo M ω -. o ~4 ~J o m ^4 co α^ ^ -..(jι (jn t ι (jι Ci ti-. ιi-. 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W μ σ %! M W O -J U1 M μ vl l *. i- ^ lD Ul C CD CD M M CO M O CD M Cn tn CO M O O O M M O ai -J Cn M M M cn lo μ co ω μ u iB o iMJi c J iii ^ o M σi ^ ffi o M μ i UKii cofli σi iS Di CO -J O m M O O Cn M "-J O O CD M cn CJl ifc. CU -J O Cn >fc. Cn cn >- i CD C0 o *. uι ^ cD «) U) W i ϋi o co co *> Λ Ciι J j» o w ~ι iji M ^ no -J o m -) ifl μ ω o CO M M to M J CO CO CD CD O CD 4-- O O O M O -J M Cπ CD ~^ Cπ O O CO M U> cn U3 M C3N CJl CO Cπ CO M M --J O -J CO CD Cl -J ∞ CD -^ M Ul CO *» --J CO CO cn O ιP» M O M its. -> -* t- 1 -> >-* 1-* i- 1 h- 1 I-' -' t-' -' t- i i-* h-' t-' -> t-> S-' - i t- 1 l- Λ t-> t-> ^ 1-^ t-> I-' OOOOOOOOOOOOOOOOO o- o_ o_ o o o ooooooooooooooooooooooooooooooooo O O O o o o o o o OOOOOOOOOOOO O.O O o o ooooooooooooooooooooooooooooooooo O O O ω ω ω -- -^ -4 m υi -π ιfc uι ui -i m Λ Λ cn σι cfι crι rι σι cfι ω fc ω M w ^ oi n fr * fι in m ω uι ι uι oι Λ -ι N cΛ ~j *. M (j) ijj -ι ^ ω M ι-- M M *. CΠ C0 C0 M C ) -J O C0 ( JJ 00 M M M M -Ϊ> C0 JS. 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CD J M M cD cn cn ^ cn cτi cn cn co o^ cn --J cn cn m cn cn cn cn oo cn cn -- j ra co co ω co ra co co cD co co m ω cn ω co ra co co ω cD ω ω ω co co co m co co ω co co cn cn cn O Ω Ω a Ω to Ω Ω O Ω Ω a Ω Ω Ω O Ω Ω O O Ω Ω a O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p H μ 3 H- H μ3 H H H H t-3 f^ H 3 H H H μ 3 H H ι-3 H H « H 3 μ 3 H μ 3 H H H μ3 H H ι-3 H μ 3 ι-3 μ 3 H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo 22222222222222222222222222222222222222222222222.32222222222222 oo cD co co oo ^ -J -j -j -J -j ^ ^ -J -J n cn c c^ oN cn cn c cn cn cn cπ cπ n cπ cn c^ ιf-. ω o cD co -j cn r-. ω θ u3 θ3 -o cn j-. co o o c ^ cn cn j -. ω Ω a a ΩΩ OΩoaΩ Ω O a Ω Ω Ω Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω a a Ω Ω a Ω Ω O Ω Ω a a Ω Ω Ω Ω O Ω Ω a Ω Ω Ω .. Ω Ω Ω Ω pa EC EC isi M O Ω o pa CO pa D Ω Ω tS pa α Ω Ω tύ pa td tfl O O Ω tD pa N tTd D Ω tύ pa N M -- MM O O Ω to M M M M M M M M MM M μ 3 ι-3 ι-3 pa pa pa pa-pa ^ ^ to ta H H H H H H H H H H H H H H H IB K EB K K t- ffi K B K t < t J t ( t , t < t t < t , t < f , 'Il l fl l β l B , l) K jS W ^ 'D iD JD tM ^ ^ lxi pd ^ ^ tr' tr' f h iH rr' t→ tr' f ^ ^ ^ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω ^ a H n H m H H tfl tS tS W lT- tS M W R tD t£ tO tfl tIl tlJ tD tB III tO tt) |ιl lD W t£ l0 tO ffl CD CD CD co oo co co oo co co oD CD CO co -j -j -j -^ -^ α^ cn cn cn cn cn cn cri cn cn CO c CO CO CO CO Co ω M M M M M M M M M M M M M M D Co ^ cπ cn cn c jι -^ CO -J c l ιI-- <-π CO ∞ CΩ M U3 cn Ul M ∞ ω co Dl C CTl -J O O CD CO O J M l W ~4 m 4-- M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M co C ιt. ιt-.-CO O CD CD O M M M CO M M M M M M M CO CD O CD O M M M M M M M CO M M M M CO M CO M M O M M M M M M M M ιC" LO M M Crι Cn -J --J CO CO CD m o j μ φ m w μ ω o uι ou θ i m μ αι co ^ cft θ ) o μ μ ui ω J o o ω uι -J (jι t o * uι m N M M φ μ ui ϋi w μ i ft N) M fc t> ϋι oι «) M cn θ M cn cn co M co -j ιt^ ιi^ ∞ cn cn M CJi M oo ιi-. cn cD M θ cn o ω ijJ co co cD C^ m Cn M CO Cn M U) CO ι(-. o ω M ∞ Cπ ω CO M --J 01 ∞ M --J CO M M ∞ M M ω θ U30 M --J ϋ Cπ ω ι cft M M OO OO M Cn M M c o^-J-J ιc -Jcncnc ∞c cn^cnrøσ cn-^c c cnc^ Ω Ω a a a Ω a Ω Ω Ω O Ω Ω a Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω a a Ω Ω Z O O O Ω Ω a a Ω Ω Ω Ω O Ω O a Ω Ω Ω Ω Ω Ω Ω MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM ιI^ ι)i 1 (^ J^ α-. ιI-. C0 C0 C0 Cϋ ω C0 C0 C0 C0 C M M M M M M M M M M M M M M M M M M M M O C-i O O O O O O O O C0 CD CD CD CD C0 CD CD C^ Cn j-. IjJ M M O CD ∞ ^ 0N CJl ι(-. ω M M O CD C0 -J cn U1 ιl^ C0 M M O C0 C0 ^ cn (Jl ιl-» C0 M M O C^ a O O Ω a O O O Ω O Ω Ω Ω Ω Ω O Ω Ω Ω O Ω Ω S Ω Ω Ω O Ω Ω a Ω O Ω O pa O σ Ω- to pa Ω Ω to pa ; DΩDΩCΩ1 BΩOO pθaa ΩθtOOOΩ pΩaa !aB Sa NΩ H3 DΩ QΩ tΩDOΩΩa to pa o Ω to pa Ω Ω to M M M M M M M M M tτ 1 Ω Ω Ω Ω a pa pa ;> pa pa < < < < |→ tr | [r < tr H t→ tr < f tr H ω ω ω w ω ta M rr l lr l tr l lr , to cn<o w c/- W M Co pa > pa pa pa M t?] M M M !?- H G ^ ^ πj ixj πd fD ^ ^ I→ tr' tr' I ' Ir' Ir' f α G G G G ^ ^ PO ^ ^ ^ Q Ω Ω Ω Ω Ω Ω Ω Ω a p a o O O O O O O ^ ^ pα ^ ω ω ω to tB to to ω ω ω tfl to ω ω tD ts ω to ω ω MM M MMMMMMMMMMMMMMMMMMMMMMMMMMMM co-~J ιfc CO C (-π cn ui cn cπ cπ cπ cπ cπ cπ cπ cn cn cπ cn cπ cn cn cn ii^ i^ CO ifa ife CjJ M M W iI^ I-J M O M M M O M M M M O CD --- I1 Cn (3N CD C0 ^ --J -J C0 CD CX) CD CD 00 O CD CO D CO M O C I O O ιl^ M tO O M M -J O -J -- CO --J M ιI- ^ M ' Cn M M Ul ιfe J M cn Cn CO M Cπ o Cl CD ιI^ ιI-- O Cn C^ M iI-- M CO M M --J CO C CO <Tl C-) M CD Cn U3 CD Cn M U300 M --J M -O it-. O O Cn i-3 ) CO CO M M CD -J M W O iI-. M M CD CD (jJ ( -0 CD C0 Cn C0 M CD M M M Ul O M M M O O C0 M C\n O CJ C;n -J cTl C0 C0 M M C0 cn C^ -4 m MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMCOMMMMMMMMMMMMMMMMMMMMMMMMMM co CDCDCDCDCOCDOMOCDCDCO-JCniI-. Cjl M CD Cn M W ---I Cn j-. cn CD -J Cn -J M M Ul ) CD --J CD ---J CD O m m M M 73 c Cπ u) ι!-' Cπ cπ ^ cn cn σN ω ιt 5 ' ''-. ι!^ ω <jo ω cn ιi^ ω ι!^ ι^ θ σι μ o ιft ω iJ θ ∞ ιt> m o o ω ra fc i*ι ω ijι μ m o ^ si uι ιi) m o o ιn -j ffl ∞ o ∞ n ^ M θ Φ μ ω j o μ o μ U fc N m n ιn ui ιn m m C ^ ^ C -4 -J Cπ C0 C0 c U ) O O 0 c7l C0 M --J ιI^ M Cn M ^ π M ιI^ -^ b -. O cn O ιI-- C^ uι ω ω ^ μ u μ θ i ω ffι θ J- iD Ui i uι ω J Uι ω H Ui u) o m o o iD W -J o iD μ ^ ra ^ j- -j i m ω j μ μ N -i σι w ω uι μ.cn ω i N ui to MMMMMMMM M M M M M M MMMMMM MOOOOOMMMM M \^ t- Λ l-' l- i h-' l-' -> -* )-> OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO -j -j -j NM cnoo -o -J cn M ■ σιωa j i ^ cocn cn --J oo cx>cn cn cocn cn --Jcn cn cι co cn cn--J cn cn σι cn ∞ aoo aooo ooosΩ Oo o Ω oooaoΩoooaaaoao ooo aoooΩsoΩΩOOo ooo pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo 2222S222222232222222222222233222222232222222S32222222S2222222 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O O O O O O O CO CO 3 CO CO CD CD CO CO U3 ∞ ∞ OD ∞ C0 03 CO ∞ ∞ ∞ -J -J -J --J --0 --J -J cnc_iιi--ωMMθ 3θ3-Jc c^'i^ωMMθCDco--jcnwιi^ω o øco--ic ^ι^ OΩΩaaΩΩΩΩOΩO aOΩΩaOΩΩOO asΩΩao O ooo ΩΩaOΩOΩOaΩOΩOΩΩaOΩΩΩOΩΩ pa NtBO Ω-tO pa pa D D Ω t pa MMOOΩtO pa Ωtd pa Ωt pa ΩΩtO pa oOΩtύ pa M M M M π3 d π3 π3 f tr' lr' lr , rr , tr tr , l l Ω Ω Ω Ω t- r l t tr d tr i tr < lr l tr , ffi !-, ff » ^ ^ ^ μ >^ κ: ι<: i→ l→ lr , lr , H M M M H M M M H H H H H H H H M M ra H W H O θ θθω ω ω ω ω ω ω ω ω κ! KJ- ; G G α α σ G G Q C M ω ω ω ω G tα ω ω ^ ^ !» ^ :Λ :Λ » :M ^ :D :χi :D ^ ^ ^ !^ ω tα to toω ω m ω to ωωtD ω ω ω to o3tB ω ω M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M cn cn cn cn cn cn cncπ cπcn cπ cn cn ι(-. ιl-. ιi-. ιl-. co co ( ω coω c c^ ON M O O O CD M O μ Gθ Φ U uiM Uιi- t- 1 i-> t- i - i ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooσoooooooooooooooooooooooooooooooooooooooo _o ιi^ ιi^ co co --j ^ oN π cπ cfi cn c cn σι c o-N cn cn cn cn cn uι co co cn cn to --4 M cπ ω u-. o M ιt^ M M M ιt^ ι^ co M M M Cθ M (_n cn cπ cπ (_π cjι --j co ιi^ M M M CD M cTl M CO ιl-. cn M M M CD ^ -π CO Cn M Cn ιl^ CD O M Cπ O O O O O C l Cϋ Cπ cn CD O O^ Cn ιt-- -J -J ( l O C0 cn -J M O M C0 C0 M o ω CD M cn M C0 M M O O O O O O --J -0 C0 ω --J c l ιJ-' O ∞ ιJi ( 0 O C0 O C^ -θ cn cτι -J ^ cn -n cn cn co cn cι --J co αN cn --J cn cn σN c) θocn cn --4 O Ω Ω a a Ω Ω Ω Ω O Ω Ω a O Ω Ω a Ω Ω Ω Ω O Ω Ω a a Ω Ω a Ω Ω O Ω Ω a O Ω O Ω Ω Z O Ω O Ω Ω a Ω O Ω O O Ω a Ω Ω Ω Ω O Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa OOOOOOOOOOOOO-OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222333232222222222222222222222222222222222222222222222222 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM σι σ> -n crι cn cn cn αι C/ι cπ cn cn cπ cn cn cn cπ cπ .r-. ιto -J cn ji j-. j M M θ C Co -J c cn ιj-. (- M M θ CD Co -j cn υi ιi-. co M M θ D co --J c υi ιt^ ω Ω O O Ω Ω Ω O-Ω ΩaθΩΩΩOOΩZΩOOO3aΩΩΩOOΩ0aΩOOΩZOOΩΩO0ΩΩOO0a00OΩOOΩ3ΩΩO pa W M O Ω tϋ pa d d tl ffl pa to pa N p α Ω tO pa t pa K N H H D O Cl ttl pa O D Ω tO pa O Ω tO M M M M M M M M M M O Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ir 1 f tr 1 f tr' ir' lr l lr , pa pa pa pa | r i f rr , lr l f f f tr'tr'tr'ir'tr'f lr'f lr'f MlT-HMWH WMIr'lr'lr'f f G G G G G G G a G G G G G G G a p pa CQ W i rjj CO O W n c p p ^ ^ ^ ^ ^ ^ | l |xl ^ ^ p3 p0 n3 i rjs t-Q rjd tϋ rjd tD ϋ tii rj- rø bd tii tD ø ϋd Dd rø (jj ( -ϋ co co co co ω co co co co ω co ) (j ω -o co co ω co co cυ co ω ιb ιt^ CO C C (jJ (jJ U) ω ω Cx) M M M M M M M M M M M M M O O O O O O O O O CD 3 CD CD U30D CXI CO Cθ α- CO OO tt- iC-. 1 M M M M M M M M M M M M M M M -4 cn -^ ω ω M θ o m m ω oι θ uι ∞ m n ω χi oι ω ϋi -i ιi) U o o *. Ln αi M C0 CD C0 CD M CD Cn cn ω co u fc μ ~ j φ W m ∞ J ui M N) N (» -) * W (ii o cιι 73 c I I I I I I I I I I I I I I I I I I I I I M o M M O O Cn Cn iC- M M M M O O O O O ~J -J Cn d=. C0 M M M O O O μ μ j cϋ cti ui ui Λ iMj μ μ io μ O O O I O O o m Cn C00^ O Cn M ^ C0 Cn ^ M O M C0 CD CJI M l-' ) Cn Cn Cn M 000D O --J --J C003 cn M M -J O O O ιf-. c > Cn ω to o u o w ω * M μ ∞ fc m ιi ) Φ Φ ∞ cΛ μ ft o m ι- M (jι μ μ i fc c<i M ^ co ιj ^ ui i ^ φ (j) io ιn øι J cn o ~J i co co ^ μ μ ω iD ω o M --0 --J CD Cn -J Cπ ∞ O CO C CO ιfc ' ON cn M M M CD M CD ∞ --J ιI-. M cn CD C M CO M ιt^ CO ιt-. O CTl C^ M M M M M M M M M M M M M M M M M M M O O M M MMMMMMMMMMMMM MMMMMMMMMMMMMM OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO. OOOOOOOOOOOOO M M CO ιI-. 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CD Cπ ω cn ιI-- CO ON Cn U1 --J -^ cn^coo3cncncτιcocncn ιcnoncncncocnσι^cncocncn-J-Jc^ ΩaO OΩ Ω ΩOΩ ΩaΩ Ω Ω Ω OΩ ΩaΩ O Ω O a a ΩΩΩ Ω O ΩΩa O O OΩ a OΩΩΩ Ω ΩΩΩO ΩΩ aO O ΩΩO Ω ΩaΩO Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa OOOOOQOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222222222222222222222222222222222222222222222222222 co c-j co co co co > (o co co ω j ω w co co cJ Co co co ω u) Cjo ω M M M M M M M M M M M M M M M M M M M O O O O O O O O O O CD CD CD CD CD CD CD CD CD CD C0 C0 C0 C0 OT CX3 C0 C003 CD -J --J --J -J -J --J --J -J co -o c w J^ Λ) M θ CD co ^ n cπ ιf-. co M M θ o co --J c ui ιi^ M θ CD Co ^ cn cn ιi-. ω o Ω Ω O Ω a Ω O ΩΩa O Ω Ω ΩΩΩΩ Ω OΩ Ω a ΩO Ω Ω a a 00 Ω 0 O Ω Z a 0 Ω a Ω Ω 0 Ω Ω 330 O Ω Ω O Ω ffl ffi N M O O to pa O Ω Ω O pa KN W H D D n W to pa O D Ω ω pa Pt P- O O Ω t pa H W D Ω tO M M M M M M M M M M pa pa pa pa pa pa pa.pa )a ^ >f H H H H H H H H ι^ ι3 ^ H ι3 β H H 4 β H H pa pa pa pa pa pa pa pa pa pa pa pa w !_, ^ te ffi ffi ti! l-- !-- te Ω Ω Ω Ω Ω Ω Ω !S !θ fι) jι) ?) !β & !S ia ?) fι) lH t H t t t 1 t l t t ( κ; κj κ; κ; κ; κ; κ; f; N; κ; : κ: , lr l E _- | _tr 1 _lr 1 _lr , - W W W 3 W &3 W H H H M H H M H tr l t- < t- | t t lr , t- 1 Ω Ω Ω Ω Ω Ω Ω Ω Ω M M W M W H W R ^ ^ ^ pO ?0 ?_ ^α !a ?- !Λ f ?3 a pa p ' a p ' a !z; ■ a ' ■ ^ a a cQ t co to ω to ω c o a a a a a ω ω ω ω ω ω to tD ω ixf iii tii iii rø ω ω ω -fl ω ω J-. iI-. il-. il-. iI-. iI-. U^ ifc ife it-. iI-. C CO Cu CO C <j0 C J C0 C0 C0 UJ I^ O O O O O O O O O O O CD CΩ CD CΩ C0 U3 CO CO CO CO ∞ OD CO CO CO CO Co αθ CO OO ^ -J --J --J -J c7^ C^ W cn O iI-. U1 on -n cn -n --J M M M M O -J CO co co U) co c^ CD --J O --J Cn CO CD M Cn M CD O CO ^ α3 ιi-. M M CD Cn C0 C0 c^ C co CO to ω ω ω ω ω ω CO W M M M M M M M M M M M M M M M M M M M M M M M M M M l CJ W CO I M M M M M M M M M M M M M M M M M M M M ■ -J O^ cn ιI i ) M M O O O CD CΛ CO ^ CO ∞ CO ^ ^ O M M M C CO C Ul cn cn Cn --J CD CO CD CD CD ω m O fc O CO Cn cT> O OO M 3 CD O CD M CO CX> CD CD CO M ιI^ M CO ιt O CO M ιfc -J CO ιti ιI-. cn ιI-- Cn C^ m CO Cn CD O OO O M ιI^ CD Cθ ω M O M ιl-- Cπ CO M CD CD CO --J CD M C) J^ O CO Cn M ιt^ Cn ∞ cπ M oo o c^ -J ιfc cn cn M ιi-. 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M CJ M --J cn ω o uι --J co --j c --4 --] cn ∞ o-ι ιi^ rf^ c cn --j ιi-. ιi^ cD ιi^ D D M C^ O U3 CTl Cπ ιI^ M M --J --J cn Ul U3 CΛ Cn M - Cn M M (O O CX> M M {J CD M -J CO CO cn CO M CD M CO J^ I -j-Jcn-Jcncncncocncn--Jcncncncncocncn--JoDcnoNcncncιc^ a Z Ω Z Ω Ω Ω θ Ω Ω 3 Ω Ω Ω Ω 0 O Ω a 0 O Ω Ω Ω Ω Ω Ω 0 O Ω a 00 O Ω a a 0 O Ω 00 Ω a S Ω Ω a Ω Ω 00 θ a a 0 O Ω Ω 0 O pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222222222222222222222222222222222222 -22222222222222 co uj co co co co co co co ω co co co co co ω - io cjo co co co co co co co co ω ∞ co ∞ oo co co oo ∞ co co - j --j ^ ^ -- j --j --j - j --j -j cn cn cn cn cn cΛ cn o^ lo D i oi ui fc ω Ni μ o ω ω i m w ^ u w o w o J m oi ^ ta M μ o iD ω i ai ϋi fc U M μ o ifl CO i σi Ln j- ijj M M o co co -J cn tn iC- co M M o cD Ω Ω O O Ω Ω 0,Ω Ω Ω Ω Ω O Ω Ω a O O Ω Ω O Ω Ω a tO Ω O Ω Ω a Ω O Ω O Ω Ω a a O Ω Ω Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω a Ω O Ω Ω pa α O Ω tϋ ^ Ω Ω CO pa O D Ω tO pa Ω to pa Ω Ω tO pa H M O O ttl pa O O Ω to pa ω pa tO M M M M M M M M M M M M H pa pa pa pa < < < < < pa pa pa pa pa pa pa Ω Ω Ω Ω Ω μ3 ι-3 '^ H i-3 ι^ μ3 Ω Ω Ω Ω Ω Ω Ω Ω Ω I→ lr , lr , lr l f lr l l→ t- 1 pa pa t→ f f ω ω ω w ω ω ω ω p ^ ^ m ω ω ω ω ω ω rø Kj W !7- t?d M π3 π3 π3 πJ πJ n3 >D π3 t l f lr < lr 1 f l l lr l π3 π3 h3 π3 ID πd π3 π^ t0 tJ0 t tj3 tO tD πJ t0 M W tD t 03 Dd W ID D0 rø tII D- M «f≥ if≥. ι£_- iP-. μ--. hi-- if-, if≥. i - iP≥. -- -if- if- ti-. U-. CO c CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO M M M M M M M M M M M M M M M M CO M M M CO CO -J Cn ul O M M M il-- iI-- M M M J M M M M M CO -J CO CO CD CD CD O ife W O M M CO >ts. cn Ul M CO Cn O CO OT cn ω M M n M -J cn Cn cn C0 O Cπ 00 --J Cn ιf- O --J M -j ro m NO co M M M M M M M M M M M M M M M M M M M CO M M M M M M M M M M M M M CO CO M M CO CO CO CO CO CO CO CO CO CO M M M M M M M M M M M M M M cncncncncr ι cn--JC jι cn^cnωcncπ- j cnαΛ- J ∞o∞--Jcncn m M 0J CD -J ιl-. ιl-. cn C) ιl-. C0 cn 00 ιf- M C0 CD M O C0 O CD -J M CD O M C000 CD O M M CD ∞ ιfc CJl C0 ιI^ m CD ^ CD Cn c7^ CD CD M cn O M O O CO il-. CA) CO CO CO M M CO CO CD -O M (O O Cl Cn it- M CO M CO M ifs. C^ o o o) lJ Ol ch ω ul μ J o σl Co -J Λ fll N ■J ^ o ^ ) l •J o ul Φ M O o co φ U N O -> U10 l ∞ fc μ o o3 μ αl U ^ H ^) (J^ O l o *. ^ co *> l o 73 I I I I I I I I I I I I 1 I 1 I I I I I I I I I I I I I I C ~J cn co co co -j cn cn cn cn M M M C ιf> Lo M M o M M O O L M M M M M Cn j=. CO t M M M M M M M O O O O O O O O O O O O M i(-- M M CO M m ι- θ l_ ιfc i μ uι * uι ιji j ιfc io M w μ U tJ ι- cή ^ ω uι fc o w o μ θ ι- J ή in o J N μ (iι o ω oι μ fc i£i M θ ω ijι u Φ (iι uι uι M M M --J M ω co M M cn --J M O M CO CD M M CD Cn CΛ) M cn M M Cn CJl CO --J O Cn CO I^ CO O Cπ θ CO --J M M CD O ιt-. 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(j CO CO C (_>J J O CO CO CO Cn M M M M O O O O O O O O O O CD CD CD CD CO CD CO CD CO CD O ω Ω θoo oo ooooooaooooooo Ω Ω O Ω O Ω O 00000 Ω 3 Ω 0000 pa2 M M OoΩotOo,oo paao σoO Ω tOooo pa aooooooz O O tO pa O Ω tB pa D O Ω tO pa D α Ω tO pa Ω Ω tt) pa O Ω Ω tO M M M M M M M M M M M M p Ω Ω Ω Ω Ω Ω Ω a pa a pa p 3 3 i D π3 π3 d π3 η 3 3 3 >O τ3 π3 i D lr l tr , lr , tr 1 f ID ^ f lr' lr < tr , M M M |r< ω rø ω ra Q c ω ω ^ ; i ^ ?o ?3 ^ Ω Ω G G G G G G G G G π3 3 τ3 > π3 j τd π300000000000000 σ G G G G G G G α α σ σ α G α α ^ ^ ^ ^ |D ^ ^ M l7 t?3 KI I?. to ω tB to to ω txi to ω ω toto to ω ω to to ttiω ω Ui cn cn cn ui cn cn cn cn cn cn cn cn cn ui cn cn cn cn cn cn cn cn cn c^ -j - σN cn cn c c -n cn cn oN jι cn jι cπ cn cn cπ cn ιt* ι!-. ιt* ι!^ ι^ CO c CO CO Ni i ϋi u i-jι cD m o co M M M M M M M M M M M M M m m uι in ϋi -i μ o J -i Φ o 73 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M C Cn ife M M M IjJ W M M M if- (jJ M M ifc. Cn if- M M W m K ^Ϊ Ϊ? S o ω o w ^ M o ω ^ ω w ^ m H μ ^^ ^* ^ θMooιra n co<rι i ιιuιω ^ M ouιcoN φ coω m o to ^, , m ^^ m Λ * ^ m w M ω μ φ ω H ω ω fc ∞ ω - J m o ^ M w o ^ w ^^ω - ) ωo μ m μ mωM- > iΛ ωω cn M co co cn co ^ - j co cπ o cn co o co ^ ι i-. o cn cn (j ιcD co ∞ l- 1 h-' t-' t-> - 1 t-' MMMMMMMMM M M M M M MMMMMMMM M M M M M M M MMMMMMMMMM M M M M M M M ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo CO CO if- CO CJ CO CO CO CO 'M . CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO c cn M --J co ui --4 co --- -4 --J cn c cD cn --J Cn M M CJ -^ f M --J ιt- M ιf- tJl M -J CD Cn M M C0 C0 M O --0 ιI-. CD C0 --J M M C0 M ιl-. CXl -O -J -4 ιt i Cθ θ M ιb c c ιo -- j D θ oθ ιf- -J θ σι i- o M D co cD θ ι^ c M co -4 on τι ^ σι -J co co cri cn o-'ι co cn σι ^ co co cn cn co cn cn --4 cn cn cn co cn cn --J σN o a O O O Ω Ω O O Ω Z O O O Ω O Ω Ω Z Ω O Ω O O O a Ω Ω O O O Ω a O O Ω O O O Ω a Ω Ω O O O O Ω a Ω O O O Ω O S Ω O Ω O O ' pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222222222222222222222222222222222222222222222222222 n cπ Cπ π Cπ Cn Cπ ιi^ ι- ιf- ιP- ιi it_ ιf- ιfi ι i it_. ιi^ M M O O O O O CΩ CD CD CΩ C0 C0 CΩ C0 U3 C0 CD α> CO ∞ C0 C0 CD C0 C0 C0 ^ --J M O CD OO -J cn Cπ CD CO -J cn CJl ifi CO M M O CD ∞ -J cn Cπ it- C M M O CD Ω a Ω Ω Ω Ω Ω Ω Ω O Ω Ω a Ω Ω Ω O Ω Ω B O Ω O Ω Ω a O O Ω Ω O Ω Ω 3 Ω Ω Ω O Ω O a Ω Ω Ω Ω Ω Ω Ω O Ω Ω a a a Ω a Ω Ω Ω O O pa IsHS H D O nW pa Ω Ω tO pa Ω tύ pa σ O Ω tO pa D Ω tB pa iM M Kl σ σ Ω tO pa W ffi tsi tS α Ω tO M M M M M M M M M M M < f 0 'fl t) 13 f d 'ti ifl t D 1) f 0 , O < <; < ω ω ω ω Ω tn. a pa pa a ps π3 τ3 h3 πd πJ πd π3 π3 3 π3 π3 a π3 h3 n3 π3 hd > pa pa pa a pa pa pa pa pa pa ffi ffi lii W W ft ffi to ffi W te pa pa pa pa pa pa pa H H M ^ 1 H H H HPl K HM R W tS μ i→ ^ lri μ t ^ ^ ^ ?) ?) S) JιJ >d 'l) 'fl *ι) 1 β ifl il) 'β O d d d d d H , H ^ i~S W ^ i „ s . ^ M.- H b- b_O tS Ω Ω Ω Ω Ω Ω Ω Ω Ω ω to ω ω ω ta to to tD ω ω tif ω ω ω to f- ω i i j^si CO c CO co co if- co it- co if- co ω cu - co co ω if- c co cυ c co it- co co CO ιf=. Cn O CD M ∞ O ∞ ∞ cn cn -J ∞ C0 O CD C^ -- ' - ∞ CD O CD ^ C0 CΩ M ι f ω ω M O M M ω cn --J M M Cπ co M ϋπ M cD M O M M M O ιi-> -J ∞ oo -j cπ co cD co o co o cn -J cn cn M M Cπ cn ιf- ιf- cn ιfi ι^ CO Cn CD M O Cn cn o^ Cn ιf. CD CO ^ M CO CO M CO CD O Cn 't^ O M Cπ cD M Cn CD Cn -4 M ^ ∞ ιf» --J CO fe ω cn co cn cn -J --J -J ιt- Cϋ θ θo M CD M cD --J ιf^ on M i ) Cθ -J co cD Co cπ o cD M cD CD Cn cn θ ιi-. -^ m co M MMM MMMMMMMMMMMMMMMMMMMMMMM cncncncn m CD M M cn m O it- (-n c cn cn M -J ιt» CO U 73 c M M M M M M M M M M M M M M M M M M M M M • -4 c O O M M M ιf- on cn ιt i CJ i ι f - ι f =' Cπ cπ Cπ c^ --J O O co α3 CD ∞ cn ω cπ cn OT m M M ∞ ιχι --j co --- CD θ O cn --J i^ M ιf- M M Cn ω M Cn cn ιt^ M θ ιt» C θθ θ O cn M Cn cn co co M Cπ cn cn cn c^ C0 C0 Cn O C0 cn cD M C0 -J C0 iI-. Cn C0 C0 c!N ) C0 ) if». O i C0 _^ 0N O Cn Cn M CD M O CD CD Cn O C0 C^ to ω w ^ M ^ μ M (Λ θ -> o μ ιn -. J m iji μ φ ω ω wo J θ φ μ L φ Ui ω u ω fc ra u ^ ω n m t ^ N) w ^ M θ co n in o t. ϋιo θ ! ω ι MMM M M M M M M M M M M MMMMMMMMMM M M M M M M M MMMM OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO M M CO M M M CO 03 CD M CD 00 00 O 0N M Cn M Cn C0 O -- i- i i- i M tnsi i μ wijcoffiO M^^ ^a cnMω μ muioiji Mω o w o μ in o o u ui m o μ MUi wu o J ut cnco si^ ϋiω iJiai lj c --J cτi c c c τι c -o c c ^ σι c c cD c Λ ^ co ^ c ) c c^ co co c c co cn c ^o^ c cn co cri σi -^ σ^ σi cn c cn σ^ σi CD cn c^ Ω a Ω Ω Ω Ω Ω Ω Ω O O Ω a Ω Ω Ω O Ω Ω a O O O O Ω a O O O Ω O O Ω a Ω Ω Ω O Ω Ω Ω Ω Ω O Ω Ω Ω O O Ω a a a Ω Z Ω Ω Ω O O pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa > pa pa pa p^ ri e i3 H i3 ta H H ^H ^ i3 e i3 i3 ^ H e f3 rt i3 ^ i3 H H H H e rt H ^ H H H h3 f3 ^ ^ H e H 4 ri H i3 i3 ^ H ^ t3 e 4 ^ f3 H O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 222222222222222222222222222222323222223 32222322222222333 32222 Cn cπ cn cn CJi Cπ cn cπ Cn cπ cπ cπ Cπ Cn cπ cn cji Cπ cπ cπ Cπ cn cn cn cπ cn cπ cπ C^ -j -j ^ c^ cn σ^ cn cn cn cn cn cn cn cn cn cn cπ cn cπ cπ cn cn cπ if- i!-. M M O CD OO -J cn Cn ιt- CO M M O CO CO --J Cn Cn ιf^ CJ M M O CD CO l cn Cn >fe CO M M O CD CO --J cn ϋ-| J^ O Ω Ω a Ω O Ω O Ω Ω CO Ω O Ω Ω Ω Ω Ω Ω O O Ω Ω Ω Ω O Ω Ω a Ω Ω Ω O O O 300ΩΩ000 300ΩΩΩ0ΩΩ Ω Ω Ω O Ω pa Ω Ω to - pa Ω tύ pa O O Ω to ■ pa Ω Ω td pa O Ω tO pa D D Ω tO pa HHDQB pa Ω Ω td M M M M M M M M M M M M ω ω M ω H μ H3 ι^ H !-3 3 Ω Ω Ω Ω Ω I→ f !r< r→ lr< lr< tr< tr< < < < 3 h3 π3 π^ IΛ ^ iΛ jD ^ lD ^iD ^^ ^ ωωωωω T. G G α α σ G α trtf tr'rr'iT 1 ω rørjOtti -o ωtDooroωωm ωtoωωω -j - j - j -j - j ^ ^ - j -j - j - j -^ - j -o - j -j ^ o"} c o^ cn c cΛ c G c n cn c c^ w w w M " μ μ μ μ μ μ o o o o o θ Φ Φ Φ Φ Φ ∞ co co ∞ ω α) j ^ i Ni i m m (S o\ m n oι muι ϋι ιιι Uι uι uι (ιι ιnUι j- β fc ιt ιt> CO c CO CO M cn cn cn McD M MCD Mθ cD C0 θ MM Cn C0 MM M Mω cMn ιfs. Mcn cπ cn cn Mcn cn -J ωθ -- CD U3 C0 CD ωM ωιt- ωt» ωιt- c ω ω ω ω ω co c ω ω c ω ω ω o o ω ω co ω ω ω ω c° ω ω fc o co o o ^ w co o cn Ln ffι Φ lJ j i ι>ι w ui ϋι (- uι it- it- co -J m h- i -> t-' - i t- 1 co -J CO --O if- if- m M m M M 73 M M c cD 03 -j -o -j co --J co ^ -j -j cD Co cn --J oo -^ cn cn cn -J CD oo -j oo M M O -J Co cD CD CO o o M o co co if- co if- cn --J -J cn cn o o M M CO Cn cn iC Cn cn co - j -J cn m μ i— ^ ^ u ^ μ U fc O CO μ o O M O U O O W i- U W ^ ∞ .M ^ ^ l Ul oi o ω t U Φ m O J fc O CIl in l ^ l N j μ ill M cn fc tD CO ' l CO U Ol Cn M Cn CD O Cn cn O CD CO Cn O M it- CJ Cn O it- CO CO O CO M M M - j 'cn cn Cjl M ιt- C ιt» Cn ιt- Cn θ ιt^ M cn O Cn θ O Cn CO M CO ιt- CO M CO Cπ M M CD Cn Cπ θ --J O to cn cTι cn co M Cn j ^ ιfe cn --- --J Cn o on -o --J Co t^ --J co M M Co uι co ιts. --j M cn ιt^ M M M M M M M M M M M M M M M M M M M i-^ t^ -' i-' i-> b-' i-^ ^ -> t-* ϊ-> !-> i-> ^ l-' t-' l-' l-' t-' -' t-' l-' l-' OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ifc -^ CO ω Cϋ ω CO CO CO CO CO M M CO CO CO M M M M o o a m J ∞ o φ a ∞ n iii Φ l u μ tD m ^ -J -O it- --J co co M --J CD Cn oN M Cn if- cn cn cn m --4 0 CO O O cn -J -O -J M Cn O it- cn cn O M OO Cn O -J Cn CO M cocncτ>--Jcxι∞cnGocncn ^cncncooncn--ocn-ncncncocncn----- O O θ a 0 000 Ω Ω 3 cn. 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M H ωωωtoωωtoωωωωωωmωωωωωo- ωω CO CO O) ^U ~J J J ^l l ^l ^l l l 4 ^ J ^ ^l ~l ^ l -J - l J -J ~J ] ^l ^l ^l ^l -J -J -J ^l ^l -J J -J J i l ^I j J J ^ ^J ^l l J I l -J l -O ^J ^ ^J %] l O O O CΩ CO CD CD Cø CD CD CD C0 CO C0 CO ∞ CD CO CO CD CO -J -J --J -J --J -J ^ ^ cn cn σ C^ M M M M M M M M M M M M M M M M M M θ i o ι ui ιi- -) θ ^ι co ij) *. (s m ι) -J ϋi ji U Φ M o w oi αi o μ u co tn cti oi M m ui μ μ ^ t-> i-> CO O O CD CD Cn Cπ cn -O CO CO CO CD D. CD O O M 73 M M M M M M M I h- 1 b-> -^ l^ ^ ^ )-' i-- i - i - i )--' - i - l ^ -' -' --' ^ -> \-^ ^ t--' i^ ^ -> \-^ ^ l- Λ t--' t--' l-' -' l-> \-- 1 l-> 1-* t- 1 t-' c co co o cn if- cπ cπ cπ co co o M M CD CD O CO M M M Cn Cπ Cn Cn CO C CO C O M M M M M M M M C M M M M M O M M M cn CO -O -J CD CD O M M O CD Cn Cn m co - j ω ^ μ μ w o cD -J M -) i θ fc w * o μ w ω μ uι μ ι Cfl ιa φ ^ ι^ iιj j- ω ω n Ni uι θ fc U ctι c« -J -' U θ o W i μ M M -j uι oι j ω ιf- OO M M Cπ M M M -J (-n CO C Cn M cn θ M IJ1 CO OO cn cn ιt- CD Cn --J O M CD M Cn CD OO ιfe ιti Cn M U^ to m uι - j θ ιi- W ffi - ) ^ LJ M M θ ιi- μ ι i u) j - w i ω -J M θ w iι) i ιt» μ t. φ *. m -) θ (- * o uι -j oi N) o uι o o ι ω μ φ 4- M M M M M M M M MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMM OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO co ω (jθ ιt- co j^ co co co co ω ijθ (o co ω co co ιt^ co (θ(jJ co M co M co co M C^ ) Φ ∞ ω φ μ φ m μ .fc n oι i« m N μ n o ^ ^ ^ m iϋ μ n Φ Λ Φ θ M m iΛ ∞ ω θ μ σι ^ ιfr U U j co αι cιι m -J oi ι- w σι ω o ft o o μ φ U cD M M co co on M cπ co o cn ιi-- o -J M co co M cn ιf- ιts. cn CD cn co cn o cD θ co cn co cn o co -J M C^ M CD C0 M -J cn 0 C0 O Cn ιfe ιt- ιI^ cn cn Cπ ι(-. ^ OO Cπ M 0 M M C0 M 00 CD CD CD Cπ t00D J-.03 M cncn-^--J-Jcn^cncn-ncocncn-4cτιcoo^cocncn--4cncncncncooNcn^ ΩΩaaaΩaΩΩ'Ω 0ΩΩZΩ000ΩΩ3ΩΩΩΩ0ΩΩ2;ΩΩΩΩ0OΩaΩ00Ω3ωΩ00ΩaaZΩaΩΩΩ00Ω30Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOQOOOO 2222222222222222222222222222222222222222222222222222222222222 cn cn cn cn cn cn cn cn i-^ cn cn cn cn cn cn cn cn cn σi cn cn cn σN cn cn cn cn cn c^ CD Co co co cD ∞ ∞ o3 cx> co oo oo α_ co ∞ ---j -4 -J --- --J --4 -J --J --J -J c^ ιf- C0 M M O CD C0 --J cyι Cn ιf- C0 M M O CD 00 --J Cn Cπ ιb C0 M M O CD C0 -J Cn C l ιl-. C0 M M O D C0 -J cn W Ω Ω Ω O Ω Ω on 33 Ω 3 Ω O Ω O O Ω 33 a Ω a θ Ω Ω O O Ω O Ω O Ω Ω aOOΩΩΩOΩΩ O Ω to pa nz K t-B.ffiW MNBM tDi CΩi til IB . a to a rci N N W t n σ n Ω i tToj > tι aΩOΩΩaOΩΩ ΩΩΩO mm > w wW πSniwω ■ rta t-ύ ΪP Ha « (7) ID M M M M > H M M Ω Ω Ω Ω Ω O Ω Ω Ω Ω O pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ω ω ω ω co ω Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa Ω Ω Ω Ω πa t i iτ) f lr' lr' r' l^ f lr'f lr' f rr' lD ^ ID lD is iD ^ iD ^ ^ ^ ^ po po iD ^ ^ - _ _ tr , i→ fc- , l→ t-' t- | t« fd j« >D G α G G α κ; κ; Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω ?3 !D W ^O ?3 ^0 G G G G G G G G G ' pa ' pa pa pa pa Kj j K O O O O to tD iD totii ω to tDω to to to ω to ω ω tα m ro ω ω ω to m ∞ OO CO ∞ CO CO CO ∞ CO OO OO CO ∞ CO ∞ OO OO CD CO CO CD CO CO CO CO CD CO CO ∞ co oo oo co∞ oD θo ^ --j ^ -J c c σN cn cn<^ cn cn cn oN cn cn(jι cπ cπ n (-π cπ πc^ CO c CO C C (jU C C0 if^ if- it_ C0 C C0 C0 {- C0 if^ C CO Φ co tn m φ o μ *. U fc U ) ω μ M M μ μ μ ω (yι i o φ -~J Cπ O -J cn M O C Cn Cπ --- Cn M cTι ∞ oo ii-. CD cn CO co co OT ~J ιt-- 0 (Jl C Φ O l Ul t. μ W Nl Cθ ω θ lJl O CJl Φ M -J - ) -> Ul ∞ J ( O C () ljl U O *' N> l>l W *> 0 m M M M M M M M M M M M M M M M M co i i u ω tιi N) M M N μ o Φ W μ w ω β ϋι m Φ i ω M μ μ μ o θ Φ φ φ iD θ φ ω J U M u fc -. j (s uι t m oi uι uι t> M i ι ω oi i (jι u m M O M n n CD O Cn CD CO -J M CO --J CO ιfe CO ON M O CD ιt CO M Cn M CO M CO CO CO CO M O CO -J cn --J CO --J CD --J Cn ιf- M ^ m O CO if- -J CD OcnN Mμ μ ^ w ή Λ ϋι w oι w M uι μ μ ui ιiι M ιι J φ uι o u'ffl ()j iΛ M σ> ιb ^ Φ θ3 ω o o ω m .θ fc i * u φ g ui μ *. μ M Uι μ ω cn co en O ^ C» cn C0 l-3 O ιt-. M Cπ M C0 M Cn cD C0 ιt- -D ιf- CD Cn M C0 --J --J M -0 Cn M -J O CD O C0 C0 --J C0 M C0 73 MM M M M c o μ CO CO CO M O CD O m CO - I μ i uo-Jθ(jijι to co -g feWWojwmu h-' t- l-* -' l-> t-' -> l-' t-' l-> t-> l-' l-' l-' -> l- 1 -* ^ ^ ^ , MMMMMMM OOOO M M M M M M M ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooσooooooooooooooooooooooooooooooooooooooooooooσooooo C0 M C0 (jJ Cθ co co co ω co ι!-. Cπ cn cn cπ cn Cn ιi-. ιt- ιf^ ιf- ιt- M M Cθ Co co C C0 ιf^ ι^ M C0 M CD ιI^ C0 ιt- C0 CD CD M C0 ^ -J Cπ Cϋ O C0 M C0 ιf^ C0 CD 00 M ^ C0 O cn C C0 O M O M >t- C0 ιl^ Cn Cjl C^ σNC M O CO M -O M O CO cn CO O Cn M M ιf- O M M M O CD CJ CD M Cn CO ∞ M O CO M CD --J ιt- Cπ CO on θ O O O C O C O CO M CD MCn ω ιi-. ιi^ o o σ i M ιt- ω o ωo Do cn ω o πcn -π n cD cσ cD ω j ^ m cn cn cn co cncn --J co mcn -J -o --J cn --- cn cn cn o3cn cn ^ -J --J <Ti --J c^ cn c^ Ω Ω Ω 00030 Ω Ω 3 a a Ω 3 Ω Ω Ω O O Ω a 33 Ω a Ω Ω Ω 0 O Ω S 0 Ω 0 O Ω 3 O 0 Ω ΩO 0 Ω 03 Ω 0 Ω Ω a 00 Ω 3 Ω Ω Ω 0 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p U H H 4 β tJ ι3 ^ rf H ^ β β ι3 ^ rt H H β β ^ > β H ^ ^ H ^ H ^ H H H β ri 4 ^ H3 H ^ ^ rt ι34 >-3-ι-3 H3 H H H i-3 ^ H3 H i-3 t^ o 2o2o3o2o2o2o2o2o2o2o2o2o2o2o2o2o3o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2o2 -J -J --J --J -J -J l --4 ^ --J --J ---J -J ---J -0 --4 -J ^ -J ---J -J ---J -^ Cπ cπ cπ cn cn cπ ιi-. ιt- ιf- ιii ιt- ιf^ ιt- ιf- ιt- ιf- <jo co co co co co co co co ω π ιi-. ω θ D co --J c oi ιti ω θ co ∞ --J c -π ιf- M θ D Co -j c n -^ Ω 3 Ω O Ω O Ω 03000 Ω Ω 0003000 Ω O O Ω Ω 3 Ω Ω Ω Ω Ω Ω 3 Ω Ω O Ω O Ω Ω 3 O 0 O Ω Ω O O Ω 3 Ω 000 Ω Ω 30 0 pa Ω Ω tO pa- pd M D O B pa tfl H D Ω tO pa O Ω Ω tfl pa D Ω Ω tO pa H W O Ω tO pa Ω Ω tO pa M M M M M M M M M M M M M M M M <! ι-3 μ 3 μ3 μ3 ι-3 ι-3 Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω H H H M M M M H H M H H M H H H Ω Ω Ω Ω Ω Ω Ω Ω Ω ι-3 ι^ 3 i-3 ι-3 ι^ ι-3 Ω Ω m ffi ffi W W I-- l-- tr 1 f f ιr l tr l lr ( lr , tr l f b f ^ ^ ^ ^ ^ ^ lD G a G G G G G a G G G G G G G G M M M M lT M M H M tT W H Pj H M tD tD to m tD to o- ω ω to ω oj ω o ω tD td ro ω tD ro CD CO CD CD CD CD U3 Ui CD CD CD UD CD CD U5 CD CD CD CD 3 CD CD <i) CD CD U3 CD C0 CD CD CD CD CD CD CD l^ Cn cn Cn Cn Cn Cn Cn Cn Cn iC. it- it-. it- J^ i it- ifc it- CO CO CO CO CO CO CJ CO CO M M M M M M M M M M M M M M M M O O O O O O O O O CD CO CD CD CO CD CO CO CO CO c CO M M M ( M M M M M C CO U) M C M M M CO M CO M M CO M M C C CO CO (_ C CO Cθ ω C C C CO C C C CO CO CO C ω C C CO C^ CO cfl Ni Φ θ ffi oi (ji iω o μ o θ Ni o) o ω Θ Φ θ co o μ N N μ o μ w ω co ∞ i - i ^ fc uι ui j co m cn fc tn oι (j uι (jι «. u *. *. m o c(j M M ιf O CD -J CO U5 <Tι ω ιt- ιf» M O M M O -J ∞ --J ω Cn ιt- Cπ M M --J --J ω .t- ∞ ω fc ^ μ ω w m ffi O H W O ω fi Φ ffl N μ ui ^ m m o oi φ β i w μ i μ ω ^ M o oi M ^ ui J liiJ -J o ti o φ J Ni cti iti i cii iii ^ m ) O M CD CD M CD CD co o cn cn -J -J cn cn cn cπ o . -j μ ω m ω μ co ^ i i co co ffi m ω Φ iD M co co o o Ni M ω o ϊi c i i ω ui Φ Ui ^ ui ui m MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMM • MMMMMM co cn -J © o co ∞ ∞ co co M co o co co oo co --J on o o M M Co cπ cπ ιf» cπ cn ιt- cn cπ cn cπ m M o co co cn -^ co co -j 'cn CD its. cn'cn M --J -J CD Oo co -j cn cn --J cn o co ιt-,-j co ui φ fc ifl iMϊ -j μ φ co io io ω N iMD ib Φ io co o l w o io oi o *. m N 5i μ o μ u fr M u n o μ u o j o ft w ui ffl M ^ μ A m o u o * θ i o * o oι co o φ μ co *. o o co (i) M W M M ιt' (o j iθ j M i w Cl M C0 -4 --J M M CD -J it- C0 -J C0 cn C0 iI-. Cn M M cn M Cl C0 M O M C0 -J CD Cn M M if- M M M M C0 cn cn C0 CD W 73 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M c Cn cπ Cθ Cn cπ cn cn cn ^ M M M M θ co o3 CD Cθ o CD CD Co oo co co -J cn M Cθ M C Cn cπ cn cn ιf- -J Cn cn cΛ m M 0n C0 Cn M -400 M lJ -40D O M M -J Cn Cn --J M M ιt» C0 Cπ Cd M Cπ C0 ιt- --J cD 00 Cπ c0 M M C000 ιf^ C0 M Cπ _^ ω w ai W M oi Λ ^ Φ Ui M O M Φ i iΛ μ j ω cπ ffl μ M Λ O j ro ωw w oi ^ m M co j φ ω ω ^ N Φ m J ^ m oi ω φ ffl ^ o i M o μ φ o ω u to ^ cn co M M cn M co co M -J cn cn M --j --j ιt- co ijθ Cπ co cD θo cn o cD Cθ cn cn --J co cn M Cπ ∞ o M M M M M M M M t- Λ t-> t- i l-' h-' t-* t- Λ t- i )-> )-* -> t-> )-* \-> i-' t- i t-' t-> i-' l- i l-> t-' ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo CO C0 M CO C0 CO ( -0 CO C0 cn Cπ Cn ιI-. ιt- C0-C0 C0 CO Cn Cn.Cπ 1 t- ιf^ CO CO C0.M C M CO C0 CO M ω μ μ ω u μ oι w ι- θ i» uι ∞O μ c« ω * u μ o ^ θ (iι t.uι o o J o μ μ ω o u <Λ m Φ θ ω ιii u m tπ -j M U ( ω (iι o ui i ij ιιι ω ι uι *. μ Λ Ch σι M C CO O CO ιf- --- Cn C O CO U3 CO O cn CO M cn U3 --J O --J ιt- ιti ∞ ---- CO M Cn --J CD Cn -J M --4 M CO M Cn CO Cn -J CD --J M CO ιl-> M CD Cn M M O -J C ιt» Cn 3 CO M CO CD '^ O Cπ Cn M M CD CO cn M ιfs , C^ o^ -J cn co cn co cn cn --J oo co aN cn cn co cn cyι ^ co ) cn σι cn co σι cn ^ cn cn cn Ω3Ω0Ω0ΩΩ30 O ' O Ω000Ω300ΩΩ0OOΩ3ΩΩΩΩ00Ω3ΩΩΩ000Ω30000Ω0OΩ2Ω0Ω0OΩ300 pa >o3 io3 io3 222 ∞ ∞ CO CO CO CD O0 -O ∞ C0 CO ∞ CO CO O3 CO CO -J --J ---J --J ^ --J -J ^ M M M M M M O O O O O O O O O O C0 lD CD C0 CD <X> CD CD C 0 C0 ∞ C0 C0 C003 C0 ∞ ∞ C0 C0 --J ^ --0 ---J -J -J --J -0 cn cπ ιi-. co M M θ co co ~J cn n'*. (j w μ o u) m i m ι^ ι^ ω 3 μ o ω co -j cn ui ιi- ω M o u) ω ^ (n uι ^ ω » μ o iD co -J m ui fc ω M μ o u) o i fι Ω 30 Ω Ω 3 Ω Ω 00 Ω 30 O Ω Ω Ω Ω Ω Ω 0 O Ω 3 Ω Ω Ω Ω Ω Ω Ω 0 ΩΩ3a3Ω3ΩΩΩ0ΩΩ330ΩΩΩ0ΩΩ3ΩΩΩ0 Ω pa fi O Ω tO pa ffi N H M D O ffl tB pa N K B d d O B pa D3 ΪB tsi M α Ω tύ pa M M O O tO pa ΩΩ O MMMM MMMM M M M IT , tr 1 Ω Ω Ω π3.π j τJ h3 π3 n3 π3 ! -3 μ3 3 i-3 ι-3 H H μ3 μ3 H H ι-3 π3 π3 π3 η3 ^ Iτ , rr , t , tr i ^ |S !M ^ ^ ^ ^ «; : μ H^ ffi m H θ ffi te ffi |-- ffi CO CO ^ KI KJ O O O O 0,0 O ^ ^ ^ iiJ ^ S ^ ^ ^ ^ ^ ^ K B H M H H H M M H H O Q n O O n Q Ω O n O g Z Z g Z Z Z Z Z r' h r' μ tr 1 tD to tD to ω ω to ro ω tD to to tD tD tD to tB tD tD ω |_ι 1 _ ι l - i_ ι μ i |- a l _ i |-- |-- l-- M M M M M M M M M M M M M M M O O O O O O O O O O O O O O OO O O O O O O O O O Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ ΦΦΦ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ Φ ID C0 C0 M W M M M M M M M M M O O O O O O O O O O O O CD CD C0 CΩ CD CD CD C0 CD CΩ C0 C0 C0 ∞ C0 C0 C0 C0 C0 C000 C0 --J -4 --- -J -^ OYCn Cn OS OS MMMMMMMM MM M ^ J iJi (j) Ln u o oi iD N θ M CO CO -J CO C iti OO it- it- M M M M M M M M M M M M M M M M M M M M M M cn ∞ CD ιts. -J M M 01il Cn C CO -J cn CO -J CO CO CO ~J O CD φ oi O 'J O M -J m μ U O W vi -J ui oi ii) θ Λ N α) iD uι m M cιι c uι o ω (n ι i M o o ω oo oo 73 MMMMMMMMMMMMM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM C Ni ω Φ O o ∞ i- O iD ω φ μ μ μ w ω ijo ui. j J iΛ iΛ M W M M u u i t iΛ Ui σi o -J ^ φ ω co ω g i ω o o o o O φ m ffl o -j ω t ^ ui cJi m M ui ui oi -j ow d wcn i J oio cn i φ i M ui o oj M φ cn uj w J cήμ o μμ ∞ μ fc Λ w ^ fc U iΛ fc ui J ^ oi iΛ iji ui cB iii o N 1 ω cft o μ o μ ω w ffi Φ -1 l M o •J J U ϋ1 W l^ o u u l O ^) ^ fc Ln μ lJ CΛ ^ J O) lJl O O (Jl ^ι ω ^ ^ μ cB ^) Ul ■J ι^ (Il Φ co o ω o o c^) ω ω cn is M M Oi O Φ 'J Φ Ui cri Φ O M j oi ω u o ^ Φ O i- H O U ϋi W μ μ u M M O o o μ i& φ φ μ O -i ω i U iii m o μ ϋi o -J i o H MMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMM MMM t-' t-^ ^ 1-^ -^ I-' OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ιt» ^ j-. j-. ι» u-. j-. u^ ιfi ιf- ιt- ω ω c c co o ω co- J j u) C ω CO Cn -4 -J ιt i O O M M O O CO CD CO CO M M M O M ιf- CD CO ιl-. M O M O M CO M M cn M M θN CD O CO cn M -J ιP- O CD θ CO Cπ Ul CO CO CO M O U^ - ) « m μ i j ι ω w μ θ (iι fr in u o o ^ o M μ ^ o ω uι μ H o ! ω ιιι ui vi M M ω M M φ μ i cn u μ -j M k m ui Φ ^ Ln o t. uι J Φ o ιcι o M CO M Cn CO CO OO M Cn ιfs. CO CO M cn on M CD CO cn O CO M -- CO M M ιf- cn Cn -J 03 CO CD M Cn θ --J M C^ cn -J oo cn cn --J cn cΛ σι co cn cn ^oo cn θN cn cn cn cn cn o3 cn cn --J cn cn cn 0300 Ω 3 Ω Ω O O O Ω 300000 Ω Ω Ω O Ω Ω 3 Ω Ω Ω O O Ω Ω O O Ω 333 Ω 3 Ω Ω Ω O O Ω 330 Ω Ω Ω O O Ω 3 Ω Ω Ω O O pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H f-3 i-3 ( -3 H3 H HI Hi-3 «i-3 4t-3 ^ ) - .3. »f-33.. Hi- _3 ιi-3 _3 Hi- _- βH3 Hi-3 «!-3 H3->-3 H>-3 H ) -3 βi-_ ^i-- ^>-3 - U- - β- H_ H- H_ β_ ^ ^ β H H U H β ^ H U H H H H H ri H H U U H H U H OOOOOOOO oOoOoOnOnOoOoOnOnOo O- oO oO oO oO nO oO oO nO oO nO oO nO O oO nO rOn o OoOoOnOnOOoOrO-i oOnOoOnOoO O ' O - O - O ~ O ~ O ~ O ~ O ~ O ~ O ~ O ~ O ~ OO 2222222222222222222 ^ 222222222232222222222222222223222222222222 CO CO CO ∞ CO CO OD OO ∞ CO CO CO CO OD CO CO CO CD ∞ CO CO CO ∞ CO CO CO ∞ ∞ ∞ ∞ -j -j -j --j -- -j --j -4 cn cn cn cn oN θN cn -n cn o Cπ c ι cπ cn cjι cπ cπ cπ cn cπ ιi^ -J θN Cn ιt- CO M M O CD ∞ -J cn Cπ ιta. CO M M O CO CO -J cn Cn ιf^ CO M M O CD CO -J cn Cn ιt- CO M M O CD ∞ O Ω røtotD-otύ Dtoωtsω αωtDωωtotD Dt L ω MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO o o o o o co u3 co cD CD Co co co cn o3 co co oo co -- j - j -- j --j - j -j ^ -- j cn cn σN cn cn <3N cn o^ 73 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M c ιf- M C0 ιt» Cπ --J -- cn cn cn θ U3 CD ∞ ^ Cπ cn cn Cπ M M M M Cπ Cπ ιt- ιf » CD I ) CD CD CD m Cn M C0 ~-J ON -J Cn ON CD M Cn it- it- UJ M M C0 --4 M i!^ O0 CO --J W M -J CO M cn CO Cn i cn -o cπ ιt^ co --j ^ ιt- cπ cn M M M M ιt» cn co θ M co -π co M co M ω cπ ιt- cπ M M cπ ιf- co cπ cπ M -J θ ^ to m μ fc J i ω si μ w ^ W Φ θ J ∞ μ uι ιn θ ιii o μ μ μ ω μ φ μ Λ w ^ ω o μ W -ι n ιn o (j φ i. ^ o co rι φ (- M iD (~ ~ι uι μ *> u ω MMMM MMMOOOOOMMMMMMM MMMMMMMMMMMM -> I-* i-> l- 1 i-> l-÷ l-> h-> i-* >-> I- 1 OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO CJ CO C0 C0 ιfa. ιf- ιI-. ιfs. ιt- ιf» M M M M M ιt- ιf^ ιf^ ιt- CO- > CO C0 ιf- ιt- U^ c/ι --J co ιD O Cθ CD ιt- c^ Cn cn cπ Cπ Cπ ( j η oN ιt- CJ Cn co cθ M_. co Cθ Co M C cn cα M M ∞ W M m μffi i ~ j N ) M o o o o o J φ * o w w o Ni uι i!i si m o cή a uo μ uH μ m W cn iΛθ! ij co* j uιcfl n i() ωoj ω m ft J cή ~J ωμ ιt- cn ι^ n M D ijα o -n o o o o θ ιf- cn σ c ιfe c oo o cn --j U3 ιt- o ij --j ∞ ^ cn cocncn -Jcncocn σN--Jcoco cnoNcncocncn--Jcn cτιcτicnco σN c^ 00003 Ω 0 O 03000 Ω Ω 00030 O Ω 00 O Ω 333 O 2 O Ω 00 Ω 0300 Ω Ω Ω 0 O 03 Ω Ω 00 O Ω 33 Ω Ω 0 Ω 0 Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ^i p pa. pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H ι-3 μ3 >-3 H ι-3 H >^ >- t-3 μ3 ^ t-3 t-3 ι-3 H μ3 ι-3 i-3 H μ 3 3 μ 3 ι-3 ι-3 rt H ι^ ϊ ι-3 H H H ι-3 ι-3 H ι→ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ' 22222222222323332222222222222222222222222222'22322222222222222 CO Cθ υ3 <XI 3 CD CD CD CD CD CD CD CD CO CD CD CD CD CD CD CD CD CD U5 CD CD CD CD CD CD CD CD CD CD CD C^ CO CO CO W IjO CO CO IJ CO M M M M M M M M M M M M M M M M M M M M O Q O O O O O O O O CD CD CD CD CD VD CD CD CD CD CO CO ∞ Co m CO CO OO OO ∞ co i cn cn ιf. co M M θ co ∞ -J cn cπ ιt- co M M θ cD co --J cn cn ιi^ co M M o co co --J cn cπ ιt- co M CO Ω ._ Ω .. O Ω Ω 3 Ω Ω Ω Ω O Ω Ω 3 O O Ω Ω O Ω Ω 3 O Ω Ω Ω O Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω 0 Ω Ω 3 Ω 0 Ω 0 Ω Ω 3 O Ω Ω 3 Ω Ω O ΩΩ ttoO pa O Ω Ω tύ pa O O OO ΩΩ ttoo pa tO pa t M O Ω tύ pa Ω Ω to pa Ω Ω tO pa pa o Ω M M M M M M 2 2 2 2 2 2 2 H M H H H H M H pa pa pa pa pa p3 pa pa (n Ω Ω Ω pa pa p3 pa pa n (D Ω Ω Ω Ω Ω Ω Ω < <! < < H H H μ 3 μ 3 ι-3 H Ω Ω Ω Ω f D π3 H M H M M M Kt' t-' l→ lr' -→ f f ir' ω M 3 H H3 H H H H M P W M M M K M τ3 π3 3 τ3 3 π3 iD τJ a pa ωmtDtD ω ωto tD rooatoωωtotβtoto tDω osωωω MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM co co co cø co cD co ∞ ∞ oo ∞ ∞ ro ∞ ∞ -J ^ -J -j -J --J --J ^ cn σι cn cn cπ cn c^ CO c CO M M M M M M M M M M M M M M M Co co ω ui ω co co ω uJ Co cϋ co co co ω CO Cn Cn 0N ιt ιt- cn cn 03 cn C000 --4 --4 C0 CD Cn ιt- ιts. M θ ' O M M M M M C0 ιf- ιt^ CO Cn M O ON M CD C Cn -J O CD -J Cn c£r M cn M --J C -J C cn cn Cn co co -j cn --- --J M Co cD M co ιt- - ι co cπ M ιt- co -J cn cD M o o oo O M M CΛ C M ιf- O M Cn -J σN Cn Cn cθ CO CO M CO CJl ιl-' O CO CD Cπ m I I I co ■ ~-J CU Cπ cn m ιb μ (ji H m φ ω Cwn. - —J . cuni u ^i μμ Mw ^«) ωW ^J oo ^ω mcfι μ --ii uuιι uσιι ∞co oo --JJ ij oo iufl3 θo mco ^ιfc uUιι u-τι ^ω σι θo m-ι iσ3iι θθ ccoo -4i oθ uιιιι ω) ^fc Uω) θo θθ w μ j a ) ^ ιn -J w ffl o σι M μ φ 73 l l l l l l l I I I M M M M M M M M M C Cπ it- C M M M O if- M CO M O O O O M O O M O O O M O O M M Cn M W it- Cn cn 'f^ Cπ cn Cn it- Cπ cπ cn CO cn CD aD -^ -J ∞ m CD M M Cn ιI^ CO CD CO ιt- CO CO M O CO CO CO M CO M M ιI^ ιl-- M Cn Cπ ιt!. CO cn Cn CO ^ ιI-. ιt- CO CO O CO M O M CO CO CO -J M --J CD Cπ M crι Cn cn O CO CO M CD Cn Cπ cθ ιts. Cπ cn CD M M M OD ιfe to u cn <n fc ∞ w ω u o μ μ u ω o * --ι μ ω co ^ i co cή M θ φ W Φ M θ j ω co o M w μ m θ i m w o u w uι cn j * o fc i- θ j φ o w σι ^ )-> -> t--> l-> t- ^ -' Λ i-^ l-' t-> i- i l-> MMMMMMMM M M M M M M MMMMMMMM MMMM MMMMMMMM M MM OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO M CO CO ifc CO CO it- ifc CO CO CO CO CO CO CO CO CO CO ω COCJ ω co CO Cυ CO M M O M M ω tjJ M ω ιt»-ιf. if- O Φ U W θ o cn o o ui Φ Φ io ^ - ) m ω -J uι W -J W fc N ) μ iJ θ ω i o ii θ M uι w u u ^ M oι c(i m -J uι * ' θ Φ o μ W θ o o ijι 00 Cn cn Un O 00 Cn --J --J ^ C0 C0 CD 0n C0 C0 M C0 CD it- Cn c0 C0 M --J CD C0 C0 O C0 C0 ---J W ιf» cD ιt- Cθ -n σ^ θN --J --J cn M ιt i Co o co θ ιf> M -4 ∞ cπ ιt- cjι M co cn cπ cji ιi-. cjι c^ M cncnσ^∞cncn^cncncncnooσ cn---∞∞σ cn∞cncn- J ∞cnσ^ ωθΩ0003000Ω0003000ΩOΩ0200θaΩ000300000-OΩ03ΩΩΩOΩΩ3Ω00000300Ω3ΩO pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p> pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa-pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H U H H ι3 H H ι3 H ι3 H H H H ^ H H H H ^ H U H H H H H H H ή H β β H H H 4 H H3 ι3 β H H H H H H H H ι3 H H H U H H H H OOOOOOOOOOOOOO OOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOO O OOOO O OOO 2222222222222222222222222222222333222222222222222222222222222 CD CO CO CO CO CO CO CD CD CO CQ CD CO CD CD U3 CO CO CD CO CO CO CO CO CO CO CO CO 1£> C0 CD CO 3 C^ U> CD CΩ CΩ CO CO C0 CO CD CD ∞ Cθ αD O3 C0 CO C0 C0 C0 CX> -J -^ -J --J -J --J --J --4 CD ∞ --J cn Cn ιi^ co M M θ c co -J cn cπ ιi^ cϋ M M θ co co --j oN Cn ιf^ co M M θ o co --J σ^ Cn ιti ω O Ω Ω Ω Ω Ω Ω Ω O Ω Ω 3ΩΩΩΩΩΩΩOΩΩ 33ΩΩ3ΩΩO ΩΩa00OO00Ω3OOΩaΩΩΩ00Ω3ΩCQΩΩ0OΩ3Ω ffi rsi pj M D D Ω tO- pa NKMoαnω pa W M O σ Ω to p oαΩtύ pa p QOtO pa M O O to pa M M M M MM M M M MM H3 3 t-3 H H H H μ3 ι-3 3 μ3 H π3 r π3 3 πd πd i-d >D π3 η3 π3 ffi ta W W E K K i^ j ^ tC ID EC tD ffi EC ffi K W ffi ffi H H H H H H H M M M Cα ω iD ^^ ^ ^ ^ paiD j pdpα ^ H R MM H tS W H W MM ωωco w ωω totB ωtsωωωωtDωtαtDtDtDωωωmωtBraωiDωω MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM cfimσiσicfloimmσi Λ Tim fiLnuiuiuiωuiiiuiiri nibΛΛ M uι i 73 I I I I I I I I I I I I I I I I I I t i l l I I I I I I I t I I I I I ON Cn Cn Cn if. ^ C M O O M O CO C CO M CO M M O O O O M O M O O O O O CO CO M M M O O O M Cn Cn ιt-. M M C0 M O O O M M c m to t-> - t >-> * μμμμμμμ MMMMMMMMMMMM i- 1 ^ h-' i-' i- 1 i-^ h-' b- 1 OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO CO CO CO CO CO CO CO W CO CO IjO CO CO it- if- il-. CO it' Φ -j ω ∞ oo μ u Cn M C M U ) M cn cTi --J it- M CO M CI> M Cn CO M Cn M it- CO --J Cn ---I C CD il-> -^ uι ra w μ ^ si cιι co j oo on cn cn cn cn cn cnco cn cn -J cn cn cn cn cn cn cn -o cn cn -J --J cn cn --J cn on ∞ O Ω Ω Ω Ω Ω O Ω O Ω Ω 3 Ω Ω Ω Ω Ω Ω Ω O Ω Ω 3 a θ Ω 3 Ω Ω O Ω Ω a θ O O Ω O Ω Ω a θ Ω Ω 3 Ω Ω Ω O Ω Ω a Ω C0 O Ω O Ω Ω a Ω M M ' t-> I-' l- , - 1 t-> l-> i-' -' l-> l-' -> l-' l l-> l-> l-' h-> - i )- i - i )- i l-' l- i * >- i l- i >-' }-' l-' -' l- 1 t- 1 l- i h-' -> i-' t-' I-' i-> l-> l-> >-' \-' t-' t- 1 t-' oooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooo—oooooooooo σσoooooooooooooo cn cn cπ cn cn cπ cn cπ ui cπ cπ ii^ it- it- iti if- it- it- if- it- it- cα ω O CD C0 -J cl 0l ιf- C0 M M O CD C0 ---J cn cn tl-. C0 M M O CD C0 -J cn Cn ιt- C0 M M O C0 CX3 -J c^ Ω Ω 3 a 0 Ω Ω 0 Ω Ω a Ω 0 Ω 0 Ω Ω 33 a Ω 3 Ω Ω Ω 0 Ω Ω a Ω 0 Ω Ω 30 Ω 0 Ω Ω a 00 Ω Ω Ω 0 Ω 0 a 0 Ω Ω a Ω Ω Ω Ω 0 Ω Ω a pa σ σ θ tD - pa Ω Ω tύ pa EC EC ιsι M O Ω tO pa CO pa O tO pa H H D Q M pa pa O Ω Ω tO pa M M M M ' M M M M M M M pa pa pa pa pa pa pa pa pa i-3 H3 H3 i-3 i-3 i-3 H_ pa pa pa pa pa pa pa pa pa pa p pa pa pa pa pa c Co to CQ CO CO Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω H M H H M H H H rr | ωω c c t73 w ω ω : !-- tD ffi w i-- Eq ^ ^ ^ ^ ^ & po 2 Z 2 Z Z z z?ι j) ? ) ^ > ) W ^ β n o Q o o Ω Q Q Cι n ^ ji ϊi » tιi jJ jι α α α cι α G G α α κ; '<; B M H H M BH κ ro do to tD ω tD to ω tD ω to ts tD to ω to ω to ω MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM ω co co co ω co co ω w co co co ω co co co co co co cu co co co co co co co co co co co ij iπ ui Λ A fe fc Λ Λ i- ft u ω u u y u u M w i w w w M i iO M μ μ M μ o o o o o o Φ io ω iO φ Φ Co o co co i ^ ^ i g j i CO c CO coco co co coco co coω co coco ω co CO M M CO CΛ it-. Cπ cn CO if- Cn Cn M il-. it- UJ CD O CD cn cn OO m ∞ uι co ωo o Λ * i o μ iD Ui * Ln co o μ i() oι θφ μ u o cii ^ n u ρ ω μ o cfι ∞ μ ι μ M M M M OO M ιt^ cn CD CO ιf- Cn Cn M ιf- M M Cl CO -J -J CD M M ιt- M ιt- co M co w cn cn cn ιi^ M -J m I I I I I I I I I I I I 1 1 1 I co cncncncococococococo M O M M M M O O cn -~I cn Cπ ιt> ιC C M M M M O O O O O M O M cn cn cn it. co M M M O O O M O O M O O O M M m -J CO M ιt» ιf» m cn cn co co cn u m u w o θ i o ft o w ιfc Λ o *. μ φ M o cn -J α) ϋι J W Co μ 73 I I I I I I I C -j Cπ cπ co ∞ oo ^ cn cπ Cn cn ιt- ιt- ,t- C >t- ιt- ιt- C ιts. co ιi-. ιt» i- ιt- O O O M O CO M M M O O O O m o Λ j fc cn -i μ o Φ fr M O ^ -J ω M ij μ ω o ui ui μ o ω u M n u io o o u fr ω uco M m Λ ib ^ w o Λ n ω μ μ ui i vi ui co w μ ii- u -i J Oϊω ii ∞ M io M μ j φ φ oαi w a i φ ω ^ m J O Ni φ W -jω M o w o jj uiw -' i o is μ Φ O J ω co i μ Ln w u ra w to c -J ∞ -J cD Co oD M --J c c ιi^ n σ c ιto -^ M Cθ ιf» ∞ cn M Cθ M Co ui ιf- ιi-. c ιt- -j M M M M M M M M I MMOOOOOOMMM MMMMMMMMM: MMMMMMMMM M M M M OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ιt ιt=. CO CO C0 CO C0 ιt- C C0 ιt- C0 ιt=. ιf- ιt- ιt», ιt- C0 M M. M M M M ιt- ιt- ιfs. ιP- ιf- Cn Cπ ιt- tf ιti ιt- ιt- ιt- !t- jI-. ιt- O O J ON CJ Cn it- M CD i-D i— ' cn M O O M O CD Cπ cπ cπ cπ cπ un o o θ M Cn M M -^ -J Cπ M ιf=. Cθ M co M M M M cn M M Cπ co oo -^ n ^ i w iΛ oi Ni ω w ω oi μ φ αi φ U o o o o o o fc J J fc Ui cri fc -J o j o iii u to φ ∞ i n Λ o i ^Λ io j φ o μ cΛ ω μ tii M co cτι θ M co ^ cn cπ ιf-. ^ cπ cπ cn o cn co cn o o o o o o o co co co co o co cn cD C M M Cπ co cn o ∞ o cn M c^ cncn-J~Jcocncncocn <_n-Jcnoo-ncocncn-J--J-Jcn^cncncn∞cncn^cncooncn Ω Ω 3 a 00 Ω 000 a Ω 0 Ω 000333 Ω 3 Ω Ω Ω 0 Ω Ω 3 Ω 0 O 030000 Ω a 0000 Ω 00 Ω 30 O Ω 3 Ω 0 Ω Ω 00 Ω 3 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa py pa > pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H >-3 μ3 H i^ H >-3 μ3 ι-3 μ3 H ι-3 μ 3 ι- ι^ H ι-3 H3 i-3 >-3 H3 i-3 3 i-3 ι-3 3 H H ι-3 H μ3 H ι-3 i-3 H μ 3 H >-- ι^ 000000000000000000000000000000-0000000000000000000000000000000 2222222222222222222222222222222222222222222222223222222222222 M M M M M M M M M M M M M M M M M M M M M M M M M M M M I-^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M O O O O O O O O O O CD CD CD C0 C0 CD CD C0 U3 CD 0D CX) C0 C0 C0 C0 C0 C0 C0 C0 ^ --J --J -J -J -- -J --J --J ^ cn c^ M O C0 C0 -J cn Cπ ιt- lj0 M M O C0 C0 --J cn Cn ιI^ C0 M M O CD C0 --J cn Cn ιti C0 M M O CD 00 -J cn Cπ ιt- C0 Ω O O Ω 3 Ω Ω Ω,Ω OOΩ3ΩWΩΩOΩΩ 330ΩΩΩ0ΩΩ 333Ω3ΩΩΩOΩΩ 300ΩΩ30Ω Ω3-OOOOΩOOΩ3ΩO CO pa σOΩM P B σ Ω td pa HBDOB pa EC EC N td O Ω to ^ CO pa pa WP-DΩt pa as M M M M M M M M pa pa ppaa ppaa ppaa MM MM HH HH HH HH HH MM S 2 2 2 2 2 2 2 Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa L _→ ! _→ M tr* ttr r 4 1 ^ t- 1 M _ M ' |_→ t_i ' t_ l' t.r ( t_r , ! ' r. 1 t.?a W.. t.? H_ t_^ M _ H M f _ _ .. _ _ _ _ . l^ 1 t- | t- , rHt- , -^ fc- , t^lr 1 l^ , t t- 1 -Ht- 1 t^ , pa pa pa H H W pj t?d M I? M ι^ 3 ι- μ3 ι- 3 ι^ H 3 3 3 3 a a a 3 3 ΩΩΩΩ ΩΩΩ Ω ΩΩΩpa pa pa pa pa ^ G αα σG G G-Gα pa pa tD tD ωto ω tD tD tD tD to ω to tD to ωto ωto toto ω tDtDffl ω ω MMMMMMMMMMMM MMMMM if- lP- lP- lP- l f- l t- lf- lP- lf- lt- l t- l & ( > CO CO CO CO M M M M M M M CO c CO M M M M M M M M M M M M M M M M M M M M M CO M M M M M M M M M M M M M M M M M M M M M M M CO M CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO M θ M M M ιt- M ιt- co M M C ι-- -J σN cn cn co ιp- cn -ι C) CD co.co ~j it-. cn cn ~J co cn -J co --j -j j cn cn -J CO cD cn co cD O CD O M M o o M M M O M M M M O on o co co cn -J M M ιf^ θ M M Cn αD M M -o cn cn o cn cD Cθ cn cπ cn U3 θ co cn M C cn (jJ ∞ M --j ιi^ m M M Cπ cn ∞ o o μ o u Lj μ φ o o ω J Ui J cn μ fc O M iΛ M U si Φ o o fc o co cii ui M iΛ fc co ^ μ M Φ cn ω M ui ui co μ j M cn fc oo ijj ^ Λ- co co ιt- o3 cn o co υ3 M Co cn cD θ θo M M crι ιt- co ιi^ ιt- o o cn CD ∞ co cD cn cπ M CD ιf » Cn M θ θ o θ ιt- c^ m CO I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I CO M M M M Cθ CO M M M M M M ιf- CO M θ σ θ O O M M M CO M M M M CO cn -J Cn -^ CO --J cn CO CO ιf- ιti M M M M M M M M CO Cπ --l σN Cπ Cπ C Λ I m ui ^ fr -j ^ u ^ ω co m a αi μ o J W ^ o w m ^ μ ω μ w w Ln ^ fc ω μ φ fc o μ M ffi φ co o u ω μ μ M Nj ω M M Ui σi Φ m co u ui m o ω -J fli ^ w ui ω ui it μ iD M σi ω -J co ω ^ co ^ iD - ro M LJ Λ fc o co ui σi -J o w ω o i-' ω o ca o co σi m co co ji m J-. CO ιt- CD --J ∞ OD CO M M --J Cπ M -- --J Cn Cπ O on M CO M -J CO Cπ CO -J --J CD θ M M CO CD CO M M Cn Cn ∞ 73 c M M M M M cn cn oo co co co co M M M θ CD CD CD Co cπ --J m ϋi μ o iD ffi M iD O i. μ io ui co-ιf» ,t- to M CO ■ -J 3 CD l- » I- 1 M M M M . MMH- 1 !—'I-'MMM MOOOOOOMMMMM MMMM OOOOOOOOOOOOOOOOOOOOOOOOOOOOO o o o o oooooooooooooo OOOOOOOOOOOOOO OOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOO OOOOOOOOOOOOOO 'OOOOOOOOOOOOO C cn o cD Cn M co M M -J M Cπ cπ co O O C0 C0 -~J Cn C0 cn M O O C0 cn co cn cn ^ cn cn cn cn co cn cn ^ cn cn cn cnco cn oN --J ^ co cn cn cn co c^ Ω OOΩ3 ΩΩ Ω Ω OOΩ3Ω COΩ Ω O O Ω 3300 Ω Ω 00033303ΩΩ ΩOΩ Ω 3 Ω OOΩ 300Ω 30000ΩO Ω 0300 pa pa pa pa pa pa pa pa pa pa. a pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa 3 ι-3 i-3 ι-3 !-3 H H μ3 H ι-3 ι-3 ι-3 H ι^ ι-3 >-3 ι- ι-3 μ 3 μ H i-3 ι^ h H H 3 3 μ 3 ι-3 t-3 t-3 !-3 i^ H ι^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222222222222222222222222222222222222222222222222222 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM co ∞ oo -j --j --4 --j --- --j --o ^ -j -j cn cn σN cn σι on cn cn cn w cn uι cπ cn cn cn cn (^ M o co i ca ui ^ u μ o Φ ∞ ^σi -i ^ uw μ O ffi i m cn fc U M μ o CD i m ui ^ J W μ o ω i ii iii iii ω μ o ω J σi Ui i' s ω M ΩOΩΩ3 3 03 pa ω ω ω ω ω t→ t→ lr' Ir' Ir' l→ tr i lr' Ω Ω Ω Ω EC ffi EC ffi nc W EC EC EC EC Ir' f M M M M W M Mfe. M H M H M Ir' t→ lr' ir' H H H p ^ !ii iii !» α α c G q c c G (β tn toBi toto ω (aω α ιs [o w(o Bi ιa oι t(i Bα α α α G G α α α α α d G α α α α H H H W κ H M H to to ω ω tα dJ to ω ω ω ω ω tD tD tD to ω tD to tD tD to ω MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM Cn Cπ cn cn Cπ cn cπ cπ cπ Cn Cπ cπ cπ ιf- ιf- ιt- ιt- ιf- ιt- ιt- ιt- ιfs. ιf--ιt- M M M M i-* o o o o o o o o co cD CD Co co co co a3 ca co co co oo oo --j -- -^ -j -4 --j -J --J --J c3N CJi cn on cn c^ MM M M O O CO iIS. cn UC0i Cn M M M^MMMMMMMMMMMMMMM t- 1 l- 1 h-' t-' t-' t- J ι-' t- i ~* ι-^ -> t-÷ -' -> l-^ -' \-' \-' -' t-' l-> t-' OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ιt-μ-'-----4cncocnιt-.ιt^o3-Jcno^o3-jcnCπcocoMMMcn---JoocDMcnMθθcoc^ !& M -J M ιt=. ιI^ CO ( O CO Cπ M (jO O cn M Cn CD O M --J CD CO M M Cn M O CD CO ^ M ^ Cn --J M O CD CO M M on CO ιI^ ^ M OO ιI-. CO M --J ιf- CO CO cn M CO --J O M CO CD CD J^ O Cn O cn θ Cn CD CO Cπ cn ιI^ CΛ) O CO CD M OO CD M CD M M M on∞cncn^cncncncncocncn-Jcocncn--J^cnaN--Jcncncocncn--J--J Ω 0 O Ω 3 Ω Ω Ω Ω 0 Ω Ω 3 O 0 Ω 33 Ω 03 Ω 00 Ω O 33 O Ω Ω 00 O Ω 3 O 0 Ω Ω 00 O 03 Ω O O O O Ω O 3 Ω Ω Ω 00 O O 3 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H i -3 3 rt H H ι-a ι-3 i -3 H ι-3 μ 3 i-3 H H f -3 3 H H μ 3 H H H H μ 3 μ3 H ι^ H H 3 3 ι^ 3 H H H H ι^ μ 3 H μ 3 H H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222.222222222222222222222222222222222222222222222222 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O O O O O O O CD CD CD C0 CD CD CD CD CD CD C0 C0 C0 00 C0 ∞ cn Cn Ω Ω Ω Ω 0 Ω Ω 300 Ω Ω Ω 0 Ω 03 Ω 0 Ω Ω 0 Ω 0 S 33 Ω 30 Ω Ω 0 Ω 03 Ω Ω Ω 0 Ω Ω Ω Ω Ω O Ω Ω 30 Ω O Ω Ω 300 O 3 M O Ω tO pa * H K D Ω tO pa O O Ω tO pa K K N M ( tB pa Ω Ω tO pa Ω Ω 03 pa Ω to pa pa M M M M M M M M M tr' Ir' f l→ lr' tr' t→ f Ω Ω Ω Ω Ω Ω Ω Ω Ω tr' f lr' t→ f f t→ tr' pa ^ pa ^ pa pa p Kj ^ Ir' Ir' t→ lr' Ir' f -^ f t→ H K H M H W M ω ω ω co ω ω ω ω σ σ Q G σ G α σ σ G G G α G G G G Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω - tr< E tr< tr ( tr < tr< tr i tr J f rr < f ω tD to tD tD ω ω -o ts ω to ω o tD tD ω tD o tD ds tD ω ω M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M cn cπ cn cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cπ cri cπ cπ cn cn cn cπ cπ cn cπ c^ CD CD 5 CD CD CD CD CD CD CO C0 O0 CXI CO CO C0 OD -J --J -J -J -J --J -J -J cn cn Cn cn cTl Cn C^ CO c CO u^ ιt- ιfe ιf- ιi^ ιt^ ιf=. o o ω c ιti ιt> co j c w c ω CO o o o o o o φ ω φ ω φ μ O φ Nj u π Λ Ui i m uη ^ m ϋπ in Λ U w ω iii u M μ j iii o o ∞ ∞ ^ φ αi m ^ -J uπ M M iJi ui ω ui μ μ o oi Cø Cπ -4 C0 ιt^ cn cn --- ] ιt- O -J M O θ σ^ Cα ιt- cn Cπ M C0 ιl-. ιt-- Cπ U ) ιI^ Cn Cπ M M ιt- ιt- Cn OO CD -J CO O --- O CD O Cπ Cπ CD ιt> M M O CO M CO M Cn o CO CO M CO Cn CD O Cn M ιt» (J1 CO M cyι ιt- D ιf i oco W φ* Λθ i_ φω ω θ j cn co μ j θ 'J m M-J θ W Λ θ θ iιji M ui φ θ co ^ ow w ιi- ^ θN μ m ιb J n --i ιi- o μ uι N θN m co I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I t I I I I I I I I I M O O O M M O O σ^ Cn Cn ιt» CO M M M M M M O O C M M M cn CO -J Cn cn Cπ ιti M M CO CO O O M M M.M M ιf C ιfa. C C CO CO M M M M M M M M O O O m ιt- M ιf- -J OO CD Cπ ιf» CD Cn --J cn Cπ M M C0 Cθ M M C0 Cn M CO CD --J CO cn C0 Cπ ra Cπ C0 C0 -^ m -j cπ ∞ ιt-. θ M ^ M c M Ω cn M ∞ co cπ cn ιf- ό M --j o ω ω o σι θ ∞ ιt- cπ c n m CP ιt- Cn θ CO CD Cπ Cn M ∞ !t- Cπ M M CD ω M --4 cn M M fc --J cn θ ω ιl^ CO CO M ι^ 73 i i i M M M I I I ( c I I I I I I I I I I I I I I I I 1 I I I I I I I I I I I I I I I 1 I I I I I I 1 I I I CO M O CD CO -J CO ^ ^ CO ffl | J crι uN ON ON ι^ M ω fc fc W -l ιb M M M ω U Λ ^ Ul U -l ιI- uN ιl- ω ι^ * M O O CO M O O O O O o M M M M M m o ^ iD O j ^ co j μ o o n iis φ ϋi ifc co φ φ ON ui ifc it -J fc μ o ω o j ω o Φ o ^ oi μ ^ u ^ w t- μ o μ μ ω ra ^ o μ w ω o ∞ oN αi ^ Φ Λ d-. W ιt- c o M o M ∞ cn --J M co cn M ιt=- θ M θ <^ on ιt» o o ω co o ∞ ∞ cn n M ιt» o --J ∞ to Cn M -^ CO Cn J=. Cπ M Cπ M --J -J CD M ιt» OO M M M CD CD Cπ CD Cπ (jJ O M M m C M CO M CD CO ιt=- CD ιf>. 00 ∞ -^ O CD O O O O O O O O CD O O O O CJ O O O O O O O O O O O O O O M I-' M M l-'MMi-'MMI-'I-'MM M M OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO M M M M M M M M M M M M M M M M M M M M - M M M M M M M M Cπ Cπ cn cπ cπ Cπ ιt- ιI-. Cn Cn Cn cπ Cn Cπ cπ cπ cπ Cn cn Ui ιti ιt- cn Cn Cn ιf- α^ Cπ Cn Cn ci cπ Cn Cn αi cn cn cn cπ Cn cn ui cπ Cn Cπ cπ cjn Cn cn cn cji CJi Cn ui cn cn O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O Cn C0 Cn ω cn C0 O cn l M O O M ιt= ' -0 (^ M M CD CD C0 Cn M l M C0 Cn M C0 C0 ^ J O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O ^ ^ O M CO CO O rø ^ M CO O Cπ CD M M C C CO Cn CO CO M M --J ιt- O M CO cn θ cncncncncocncn-JcococncncncocnσN-Jcn<^cncncocncn-J^-Jcn--Jcnc7^ cn cn ^ J co Ω O O Ω 00 O 30000 Ω 00 O 3 Ω Ω Ω 00 Ω 033303 Ω Ω 000 Ω 3 Ω 0 Ω 0 O Ω 3 Ω Ω Ω O 0 Ω 300 O O Ω a 00 Ω 3 O pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to H H ι-a >- H ι-3 H H3 μ3 μ3 H ι-3 H H H i-3 !-3 H >-3 >- ι- !-3 H ι-3 μ3 ι-3 f-3 ι--3 H 3 H [-3 f-3 ι-3 H H ι-3 H ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo 2222322222222222222222222222222222222222222222222222222222222 M I- , l-' M M M M M M M I-' M M M I-' , M M I- , M M M M M M M M M M M M t-> M M M |-' M M M M M M M M M M M M I- , M M M M M M M M M M M M CO CO CO CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O O O O O CD CO CO CO 3 CO U3 CD CO C0 CO C003 CO CD CO CO CO OO CO -J --J -^ --J --J -J --J -J --J -O C^ it- C M M O CD CO --J aN Cn if» W M M O CD CXl --J Cn Cn ib CO M M O CO CO -J ON Cn if=. C M M O CD CD --J C^ Ω Ω Ω O Ω Ω O O Ω 3 Ω O O O Ω Ω 33 Ω Ω Ω Ω O Ω Ω 3'Ω Ω Ω Ω 00 Ω 330 Ω 3 Ω Ω 0003 Ω Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω 00 Ω 33 O Ω 03 pa pa Ω Ω tO N M O Ω tO pa o σ Ω tfl pa M M O DΩ tD pa D O Ω tO pa O Ω tfl pa N M M M M M M M M M M M M M t→ t l→ rr , lr l lr , r , Ω Ω Ω Ω >^ H i-3 H3 H i-3 i^ tr , tr , fc lr l lr , lr < tr , l→ lr 1 H M M M M R H Ir' Ir' l→ lr' m ffi PC πa α C q ^ Kl G G G G G G ^ ^ pO ID ^ ^ ^ ω ω ω ω c rΛ rΛ rj rΛ G σ G G G G σ α ω Co rΛ ω ω ω ω cD toto ro to tDω tDtDωtoω ωtflωωooωroω tD toro to ω ω toω ωωtoωωto ω MM MMM MMMM-MMM MMMMMMMMMMMM M M M MM M M MM M MMMMMMM MMM MMMM MMMMM M MMMMMMM o^ cn cn cn σN cn cn cn cn cn cn cn cn cn σi cn cn cn cn cn cn cn cΛ cn cn cn cn cn o^ oN c^ -J ^ -j --J --4 --j -J cn σ N cn cn cn cπ cπ cn cn cπ Cn ιf- ιt- ιt- ιt- ιt- ιt- Λ CO c CO M M M C M (jJ CO CO CO C C C CO CO C Co ω ( jO M M M CO CO C C CO C M CO C C CO CO CO U ) CO C CO C CO W CO CD CD CD θ C0 O M M M ιt- ιt- CXl -J --J Cπ Cπ Cπ ιt- C0 CD CD O M C0 C0 M M U3 O O M M M M C0 -J - l cn Cn cn cn C^ μ * * m N (S θ oι o iJi μ uJ θ M μ j Nj co J N ϋJ ^i Λ σι *. oN μ ω (Λi uN C o φ j- iιj ι ) i ) uι o uι μ M.CΠ -J cn co cπ o co -J ON co cn M co M M CJ -J ON cn θ CO CO ON CD CD Cn M CO CD O M O OO CO M O --- M Cπ Cπ CO CO Cn CO cn σN Cn CO Cn M ιt» ιI-. O Cπ CO CD ιt- cn co M co co ιi-. M -J cn co co cn cπ ιf- cn M Cπ cn ιf. M CD Cπ ιt>. M ιf^ o cn M ιC» co co θ ιts , --j o ω m M M CO if- cn -j CD co co co --J -J --J -J CO CD ∞ (£l CO C00300 U3 CO CD O CD CO ^ ιt- M ιf- ιf» σi Cn ιt- ιf!> ■ j cα cn co -J cn cn cn cπ ιi^ ιf- --o cπ cn co ιt- ιf. ιt- co cπ ιt!. M C Co M M I m ui m o co ω μ O it c ^ m fc W o oN ^ ω m w ^ oN w μ o ^ μ ^ μ ω μ o -j ω μ uj ω t μ -J w μ io ω m O i oi i fc A fc ^ μ w ω j o i m CD Cn ^ O CO -J M M M tn M C CO Cn --J ω θ CD -J M -J '-O 3 M cn Cn θ --J CO O M --J M M CO C --J M O O ιt-. M ω w n ιis m ui θo u o ω ω -> J -J i uι ui o ω N ui j u M i\) Φ w cfl fc ι o m ijι -J θ Φ cft J u o u w o φ θ -j μ Λ ∞ i u φ uN ui σι 73 c I I I I I I 1 M I I I I I I I I I I I I I I I I I I I M -J CO CO -J CO CO CO O o D ∞ σι ιb W ∞ -J w -i o N ω ω σι n j- *. ~ ιi- ιi- u σi ιt ' *. ) M M O O O M it- CO M M M M M M M ιt- -j -J cn ι p ' it : - c c ιt m -J -J M M M cD Cn ~J Cπ --J M CO Cn to CO OD Cn CO M M U3 if- CO W ω -J H W ω αi ui Φ O Ui \- 1 t-> -> l- 1 l-÷ l-' >-' >-' i-> -> t- Λ l-> l-' t-^ -' l-^ t-' i-' l-' t-' h-' \- t-* * I-* t- 1 l-> i- 1 M M M O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O Q O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O woncncocncn -Jcocn Ω Ω Ω 0 Ω Ω 30 Ω Ω 3 Ω 0 Ω 0 O Ω 33 Ω O Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω 33 Ω Ω 3 Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω 00 Ω 33 pa pa ps pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ H >-3 H i-3 H H t -3 i-3 H ! ^ 3 i ^ H 3 H H i -3 H i -- H H 3 H i -3 i-3 H i -3 i-3 H i- H H H 4 i-3 H i-3 H i- H rt OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222222222222222222222222222222222222222222222222222 3 O Ω Ω O Ω Ω 3-3 O Ω Ω O Ω Ω 33ΩΩ3ΩΩOΩΩ OOΩΩΩOΩΩ3ΩΩΩΩOΩΩ 0 Ω Ω Ω Ω O Ω 0 0 Ω Ω 3 Ω O O Ω a Ω σ o Ω to pa α α Ω tϋ pa M H O O Ω 03 pa HM ΩW pa σσΩtO pa SB σ O ω to to M M M M MMM > O MM MM M M M M pa pa pa pa f> pa pa pa pa pa pa EC W ffl ED Eα K W EC W ffi Ω Ω Ω Ω Ω Ω Ω Ω Ω !r' !r l f rΛ ω ω rΛ ω ω ω ω ω [Λ rΛ ω Λ C to to H H H H H H H H t t- , ι^ , 3333333333 a 33333 ω ω to ω cn tn to ω ω w α σ α σ α α σ Q Q G G G G G G G G E0 J !D p0 pu ^0 f J J0 ?0 ? ?O pa a pa pa G to to ω ω tD u3 ω ω to ω to to tθ D3 ω tπ to ω ω ω ω MMMMMMM MMMMMMMMMMMMMMMMMMMMMMM M M M M M M M M M oαiφo ωω Niui μ ∞ l t l l l l l l l l l σi σi -j -j j co co co -J OD co φ M ui ιb -J ci) θ φ μ μ MMMMMMMM MMMMMMMMMMMMMMMMMMMMM b-' -' t- Λ - > t- i t- i Λ t-' l-' l-* -> i-' t-> t-' t-' l-> l-> OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 000000000000000000000000. σooooooooooooooooooooαooooooooooooooo d^ Cπ ι!-. ιti it- ιt=. ιt- ι!-. α^ Cπ Cn cn cn ιt- cπ cn ιt- ιt^ ιt- ^ cn M D --J Cπ ιt- -^ c c D CD C7i σ -J M θ ιt- n cn c -^ U3 Cθ M M M O O cn M M il-. cn M O O if- CO if- O it- cn Cπ CD M M CΛ O C0 M M ∞ cn M M M O ιfc M M ιf- M -0 --J CD Cn C0 M C0 ιts. C0 ιt- ■-Jcocncncocncn^^cocncncocncn--J-Jcncn^σ>σNCθcncn --Jθococ^ a 0 Ω Ω O ' O Ω a 3 O Ω Ω O Ω Ω 33 Ω Ω 3 O Ω O O Ω 3 O 0 Ω Ω Ω O O 03 Ω Ω Ω Ω O 0 Ω a 0 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 Ω 00 Ω 3 Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H H H H H H β H H H H β H ^ H β H β H β ι3 H 4 H H H H U H H rt H H i3 H H ι3 β β H3 B H H H H ι3 H H rt H β H ι3 ι3 H H β H H O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 2222222222222222222222222222222222222222222222222222222222222 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM M M M M M M M M M M M M M M M M M O O O O O O O θ σ θ C0 C0 Cø CD CD C0 C0 C0 C0 CD C0 CD 00 C0 C0 CD C0 C0 ∞ CD --J --J -J --J --J -^ Cn Cπ ιf- ω M M O CD 00 -J cn Cn ιt- C0 M M O C0 C0 --0 cn Cπ ιt» C0 M M O CD C0 -^ 0N Cn ιf=. C0 M M O CD C0 -J c^ O Ω Ω 3 Ω Ω Ω Q.Ω 0 3 0 Ω Ω Ω Ω Ω Ω 0 O Ω 3 0 0 Ω Ω Ω O Ω Ω 3 O Ω Ω 3 Ω O Ω Ω 3 Ω O Ω Ω 3 Ω Ω Ω Ω O Ω Ω Ω Ω Ω Ω O Ω Ω 3 •^ Ω Ω 03 pa N B B d d O B pa W M O Ω tD pa pa tO pa CD pa O O Ω tO pa O D Ω tO pa M M M M M M ω rΛ ω αj ; < < π3 π3 π3 π3 iD 'D τ3 π3 π3 π3 rα Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa pa pa a|r , lr , l-- , tr lr l t- < r , lr < t , lr M M H M pa pa pa pa pa pa Eα « m EC EC EG EC EC EC EC Eα tτ< lr' tr< tr< l→ lr' f iS !β ϊι) >ιl t < t t , t t < t i t H B B B B B B B fi G G G σ σ G G α κ; «: κi κ: |tι )i J ) >J β p 1 lr , l-- , lr , tr , lr l t _ ^BBBBWWBBBBBHWBBH papaααGGαααGGGGGGGGG ωωtototxitototdtoLDoato to. to tomoaωωtDωtdcotorototøtsωtoωtDω MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM ∞ CO ∞ CO CO OD CO ∞ CO CO CO ∞ CO CO CQ CO ∞ CO CO CO CO CO OO OO ∞ CD CO OO ∞ C0 C0 C0 C0 M M M M M M M M M M M M M M M M M M O O O O O O O O O C0 C0 CD CD C0 03 C0 C0 C0 --J --J -J -J --4 cn cn Cn cn cn cn cn σ^ CO c CO M M M M CO M CO M M IjO CO CO CO CO CO CO CO CO M CO CO CO W CO CO CO CO CO CO CO CO CO CO u CO CO CO CO CO CO M ω CO CO CO CD CD M CD O --J CD O O CO M CO M M M O CD O M M -J Cπ CiN Cn ιf!. M CO ιI-. Cπ J ιfc Cn ιt- ιI-. ιt- ιt- ω o cn o -J cn cn -J co M θ cD Cπ ιfe -- j cn --J o ω o ι!-. ι P» cn co co -J ω o cπ ω co co ∞ co o αi o φ fc M φ φ w μ j μ ω o μ i M ii- ω ui i μ ij fe M ϋi i A i ui W ui u N iji ω M o ϋπ ωo ω μ M j- J i o o o ui ca U ui o M iΛ uJ ^ ui oπ o αi o Λ ω μ u ij w oN O μ J αi ω m u ^ iJ o w ^ -J i M co ft ω J W Φ m ω ^ ω ^ μ J W ft -j Λ -J co μ iJ Φ m CO I -o cD CD CD θ m m 73 I I I I c i-' t-' t- 1 i-> t- 1 M CO M M M m to M MMMMMMM M M MMMMMM MM MMMM MMM MMMMMMM MMM MMMMMM M MMMMMM MMM MM M ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooσoo cn cn cn cn cn cπ cπ cn cn cn cn ιf^ ιt- ιi-. ιt» ιt- ιt- ιt- cn crrc^ ∞ oN ^ n i fl φ μ ω - ι Λ μ ^ ^ (j ^ α ) ϋi M ω ^ w Lo μ α ) u cπ ^ μ φ θ θ Φ io ω μ j U φ ω ω ui ϋJ U υ-ι cπ -j μ θ θ j w w o o{jj μw ιt> C0 CΛ CD CD CD ιt^ M σN C0 cn C0 Cn M O C0 ιt- cn M C0 ∞ -J ιt- -J ^ M M CD CD M cn C^ M Cπ C0 CD M M ∞ 00 --J σN θ ^ ω cD --J ∞ C0 M --J ιf^ cn Cϋ M C0 M CD C0 Cϋ CD M CD -J M O ιf- O CD Cn CD cocncn-Jcncncncocncn-^cncnσNcncncncncocnon-Jcococncncncoc^ OO Ω3 Ω ΩΩO OΩ3Ω Ω ΩΩ Ω Ω ΩO 0Ω3000 Ω Ω 0 O Ω 300 Ω 30O O Ω300OΩ3 Ω ΩΩΩ0OΩ3 Ω ΩΩΩ 0 O Ω 3 i— i— i— i— i— i— i— i— i— i— ι— ι— ι— ■— .— ι— r- ι— ι— .— r- ^- ^ r- M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ιt_ ιt- ιt- ιl-. ιt- ι!- * ι!-. ιt- ι!-» t!-. ι(-» ιp- ιt- !l^ ιt- ι!^ ιfc. ιf^ oo co co oo co co co c» --j -J -^ -o --J --j -J --j -^ -J cn σι cn σN cn cn cn cn cn cn cπ cn cn c^ -J cn Cn ιf- C0 M M O CD C0 --J cn Cn ιl^ C0 M M O CD C0 -^ cn Cn ιI^ C0 M M O CD 00 --J cn ( Jl ιI^ Ωn ΩIT) O Ω Ωpy 300.ΩΩ0ΩΩ aaOΩΩΩOΩΩ ΩΩΩΩΩΩΩOΩΩ 0000Ω0ΩΩ3ΩΩΩ0ΩΩ33ΩΩΩΩ00Ω30Ω Ω tO O D Ω tO pa BBdOB pa NplHDOnω pa WMDΩtO pa OΩtO pa NBDflM > ΩtO M M - M M M M M M π π3 3 3 π rD a a pa a pa pa pa pa θ O O Ω Ω Ω Ω Ω θ 3 τ3 n3 > ' τ3 τ3 τ τ3 θ Ω Ω Ω Ω O Ω- Ω Ω π3 π τ^ Ec Ec iD Ec ffitBωω co ωω cot co ι→ lr , lr , tr , l→tr l t i , t l EG EC ECEC EC κ m BH B WM BO O Hlifl J ilJ ifl Ul ZZ ZZ Z Z Z Z Z H B Pl B B B M B B IS B G Gσ G G G G G G O O O O OO OOl M ta Bi ω ω K ω K ϊd ii) tO tύ tO ID tD tO tO tO tO tD tO tD tD IS ϋa tD tD ID tO tD tS tD td lD M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO CD CO CO CD CO OO ∞ CO OO CO OO CO CO OO CO α- CO αD CO CO CO OD OD ∞ OO OO CO ∞ CO OO ∞ o o o o o o co co co cD Cθ co co co co co cD θ3 co ∞ ∞ co oo -o -J -- j -- j - j - j ^ -j --J -J --J cn cn c^ CO c CO MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMCOCOMMMMMMMMM CO o μ o o φ m -j -J -i ^ ∞ ∞ io u fc fc U o o μ w m ui -J ^ oN u ^ M M ω u ^ uN m ϋπ ^ μ w ω ^ -j i t i ω -i oN μ ω φ ω oi m ω cD φ φ CD M ιf- M CD Cn M --J θ M ιfs. co M Cn --J co σN on M θ ιt- -J M Cπ M Co cπ cn M cn co -J co σ^ cn co oN --J ω M -J CD ιt- O C0 -J 0n cD ιI^ M 03 cn C0 C0 Cn M C0 C0 C0 M Cn ιI_. Cn -J M C0 M 0D C0 M Cn O Cn M cn M ιfs. or co * o m μ aι o μ o ϋι μ w (s o o φ Φ θ w oι fc ιis ^ φ ro iΛ θ uι ω * θ φ φ -J ω w ∞ (jι t φ i ω co -i m w cιJ o ω m Λ ω θ fc J m co I I I I I I I cn cπ if- Cπ cn co M O M M M O M m I — ' CO CO cn I — ' — I 1 — ' 00 ω o ω Φ -J m C0 CD CD Vχ) Cn cn cr> ιt- O Cπ M C0 M O C0 cn M C0 O C0 CD JN ON D O co 73 i i i i i I I I I I I I I I I I I I I I I I I I I I I I I I I I I 1 c MMM MMM I MMMMM I I I I I I M I MMMMMMM I t l->l-' l-' l- i l-> -> l-' )->t-> M M cncn co co co cn ιt- Co cπ CD M ω m ιI-. CD O M ~J CO CO O O Cn CD O M CO M ioii- ooiiiO M-j O oi-JMαiφt inNi oii o oμ uo Φmuo o o -J to ιt- M ιt- ιt» ω CO CD O W --J O O --J CO μM ~--JJ iCnn oθ M c∞o θ u) *. w ω fe μ -J t μ c ιt. ιi- θ i ιo μ oN *, ιfc ιi- -J -i Φ cθ Ni cα M cn oo --j co - j -- j ιi-. θ ιt- cn σ> co co o cπ ιt- ιt- o cn o i- Λ \-' t-> i-' O C> CZ> 0 )-' )-' l-' t-> l-> t-' >- i -' ^ t-> l-^ t-' -' i-' i-ι -> ' i-' ' -' -' M M M M M M O O O O M M M M M M M ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooo ui i o ^ D j μ φ fc θ Φ Φ ^ U! _ι o o o o ∞ i iD ω w ω u M μ M t φ W Φ Ul ^ ffl vl m O O u1 l- O O O O CO Ul l O lD vl O c cncD θ cn -J oo <x> c o θD cn cn --J -J co c cncnco σιc -J c^ Ω O 0 O Ω 300000 Ω Ω 330 O Ω Ω 00 Ω 30 Ω Ω O Ω Ω Ω 00 Ω 3 O 000 Ω 0 O Ω 3 Ω Ω Ω 00 Ω 33 Ω Ω Ω Ω 00 O 30 Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa o 2o2o2o22oo2o2o3o3o2o2o22oo2o22oo22o2o2oo2o22o2o2oo3o32o2o2oo2o22o2o2o2o2oo22o2o2o2o2oo22o2o2oo22o2o2o2oo2o22o2oo22oo22oo2 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM Cn Cπ Cπ cπ Cπ Cn Cπ cn Cπ Cn cπ cπ Cπ c^ cπ cπ cn cπ cn cπ Cn cn cπ cπ cn Cπ cπ Cn cn Ui. j-. ιf- ιt- ιI-, ιts. ιt- ιt- ιt- CO CO CO CO Co ω (O CO CO CO M M M M M M M M M M M M M M M M M M M M O O O O O O O O O O CD Cθ ω ∞ -J cn n ιti C M M θ CD Co ^ cn cn ιf- W M M o D Co -^ c cn ιt- (jj M θ cD co -^ on cn ι-- ω O Ω Ω Ω O Ω Ω 3 Ω Ω Ω 0 0 0 3 0 0 0 0 0 0 0 3 0 0 Ω Ω O O Ω 0 3 Ω O Ω Ω ΩΩaΩΩΩΩ00Ω330ΩΩ0ΩΩ 3 Ω Ω Ω Ω Ω M D Ω tti pa - O Ω tύ pa O Ω Ω to pa B B d ø tB pa O Ω Ω tO pa OΩΩtfl pa ODΩtύ pa N B B d D M M M M M M M M M M M M ΩΩΩΩΩΩΩΩ 3 iD π3 f D , D l D π3 H H H H H M H H Ω Ω Ω Ω Ω Ω Ω Ω Ω H M M M H M H M M H M H H M H pa pa pa pa pa pa pa pa π3 τ3 τ3 'D iD t-<tr l tr , t- ( tr l t-'t- 1 t- f ID ^ ^ tD ^ pB pα f rr' rr' Ir' Ir' lT' ir' tr' Ir' f lr' f f l→ tr' Ir' f GG -G. ^G ^G ^GG. ^G O O O O O O O W W M M M H H M G G G G G G G G G M W t?] M.H M M H t tS W to D3 ω to m ω ω ω ω ω ω ra tD ω ω ω ω ω ω tD ω ω ω M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CD CD CD CD CO CO CD CD CD CO CD CD CD CD CD CD CD CO CD CO CD CO CO CD CD CD CD CD CD CD CD CO CD CD CQ CO CD C^ -j-j-j-j^ -j -4--Jcn-ncncnOTcncn cπcπcπcncnCπcπcπ ιi-.ιt-ιfe ιi-. ιfiιi-. ^ M M M M M M M M M M M M M M M ω cή w μ M cn cn M CD CD CD Co -o ~j -j rf-. cn co cn Co Ul * Ul Ln Ul ιl> ω oi tO O H U1001 Ul I I I I I I I I I I I I MMMMMMMMMM I 1 I I- 1 V- 1 c^ c ∞ if-.M -J n cn CO μ w o ij o μ m μ iΛ ^ ∞ ^ o ∞ l-' t-' b-' t-' t-' l-' -> \-^ l-^ i~> t- i ^ ^ ^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO M M oN θN cn α^ cn cn cn cn cn cn cn cn cjι Cn cn cn cn cn cn cn co co ∞ --j ^ iΛ iΛ Ui μ oi w μ w Φ w μ ^ M O oN Φ -i o μ W H μ fc ifr iji uJ O uπ i u fc U -i fc Φ φ ^ uj i j m -i co o ω Λ uN u o ra ∞ φ M μ o M fc O O O O O C0 ~J ιf- ιts. O M C0 ιt- C0 ιl-. ιts. C0 C0 M C0 C0 -J ∞ cn M C0 U1 O M --J Cn σN -J M M C0 Cn ω O O O ^ M C ιt- M Cπ M C0 O CD C0 M cn ιfe CD ιt- M ιt- Cπ ιf- C0 C0 ιI-> cn CD -J U5 M Cπ θ O Cπ M M M ∞ cocncncιcocnon--Jcncncncocn.o -Jcncncncncocncn-Jcococn'oNu^∞ 00 Ω Ω 0 O 03 O Ω O 0 O 03 Ω O Ω 000 Ω 300 O Ω Ω 0003 Ω Ω 0 Ω 0 O Ω 3 Ω Ω Ω Ω 0 O Ω 3300 Ω 0 O Ω 30 Ω Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pj pa pa pa pa io-3 to-3oH >o-3 io-3 io-3 HoHoHortoo3oio-3 Ho>o-3 Hoio-3 22222222223232222 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CTi ON Cn cn cTi cn cn cn cn cn Cπ un Cπ cn cπ cπ cn Cπ cπ cπ Cn ci Cn ui cn cn cn Cn cπ cπ cn cπ cπ C^ O O O O O O O O O O CD CD CD CD C0 CD C0 CD C0 C0 C0 C0 CO 00 C0 C0 C0 C0 C0 C0 --J -J -J -0 -J --J -J --J -J -0 Cn c^ CD OD --J cn Cπ ιl^ CO M M O CD OO ^ σN Cπ ιt- C M M O CD CO --J o^ Cπ ιte CO M M O CD CO -J Cn Cn ιt^ to Ω O Ω Ω 33 O-Ω Ω O Ω Ω 3 Ω O Ω Ω a Ω O Ω Ω a o Ω O Ω Ω Ω Ω Ω O Ω Ω 3 O Ω O ΩΩ3000ΩΩOΩΩ 3000ΩΩOOΩ30 Ω tO pa O O Ω tύ pa tύ to EC INI M π π Ω to pa Ω 03 pa HBdΩffl pa M M O Ω to pa M M M M M M M M M MM M Ω Ω Ω Ω Ω Ω pa - pa pa pa pa pa pa pa pa pa pa pa pa pa μ ι-a μ 3 H H ^ μ 3 μ 3 ι-3 H μ 3 ω ω ω CΛ ω c Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω μ ω ω ω rø ω ta to ω rr l tr l b lr , l→ τ H t→ ir l t H tn [fl ( 0 ffl tn [0 Z Z Z Z Z Z Z " s ^ l i» J< l ^ J ] ^ ^ !B ? ) !a ?J !il ? ) J3 ? ) J3 ?5 ^ ? ) !S !i ) J ) G G G a G G G G G G G G G G a G G a G ω ω ω ω ta ω ω ω ω w tD ω ωω ω ω ω ω tDω ω ω ω M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O CD CD CD CO CD CD CD CD CO CD CD CD CD CD CD CD CD CD CD ιn ϋi oι ι n ϋi fc fc ιt> ^ fr fc fr ^ i- iι) u u u N) Ni w w M μ H μ H H μ o o o o o o Φ Φ Φ φ iD Φ ∞ o co co oj (- ∞ co -) i CO c CO CO M M M CO CO CO CO CO CO CO CO CO'CO CO CO CO CO CO CO CO ω CO CO CO CO CO O CO CO CO CJ CO ω ω CO O CD CO CD O M Cn CO iti if- CO M M IjO CO M M M it- if- M CO it- CJl CD ^ CD CD CD CD CD CD Cn cn ∞ Φ m o w ^ o μ o o o μ it ω w μ ^ i- o m m ω ω M ω M O fc o ω μ o μ co μ u oi i ω u oi o fc u ifc iD fc fc o iii μ co ω ^ ∞ μ ^ cs ^ -- j M CD O CD -J CD if s - W if- o co co oo oo co o cn co M Co ^ cn cn co cn cn o cD cn ∞ ^ ∞ Cn -4 M CD C0 M ιt^ C0 C0 I cn C0 C0 C0 M M M C0 Cπ M Cn θ O Cπ Cn C0 M Cπ -- 03 IjJ M C0 M C0 ιts. Cn ιf^ m co l_- l_ ι t --l-'M MMI- 1 MMMMMI-'M MM MM M MMM M Mt-- , MMM MMI- i MMI- s MI- 1 M M MMMMMMMMM M c o cnu^ ncnιi-.ιf- ιi-.(jθ(_ncπωijJθM cπιt»ιt- cn ιf- --Jcn--JC^ M M -J cn cn cn it- Co co if- co co O CD O M it- CO M O it- m Φ mω ^ fc w o vi o w o μ oN M ^ j φ Oi M O Φ is ω m t ^ ^ ω ^ m i oi μ o u m μ ^ co μ o i co φ uN it' μ o o uN ^ oi w co μ μ o M m u o μ ffl W Ui μ m ^ ^ O fc ^ μ φ Nj μ m u Φ W ffi o ^ Ni o u o u ai o ^ J oi iiJ O M j ui u oi μ u Ni M -J -J o oi fc o μ iiiiiN Co uι CD co o -^ θ ιt. co ιt^ θ M cn ^ M cn --J cn co --j co co M Cn cn ιt^ ∞ co o cπ o N M on M M Cπ -j 73 I I I I I I I 1 1 I I I I I I I I I I I I I I I I I I I I I I I I I I I I I c M I I I I I I 1 I I I I I I M I I M M M M M M M 1 1 1 1 I I I M I M M M M M M M t- 1 I- 1 )-> t-' -" M M M M M M M M M M M M M M O CD Cn cn - -J it- Cl Cn cn OO -J -J CD M CD CO M M C M M M M cn 1 oo CD CO CD O CD M M M M CO M M cπ co co co co -j ιi-. cn cn -40 M 0 CD CD — J -J co co o m ιf- M ιf- -J C0 --J -J O ιf» --J O ^ O ιI-. C0 C0 M (Jl ιt- CD CD M M O M C0 M Cn ιt- uN CD CD O O M CD to co o M cri CO M CO it- cn cn M txi co cn M CO Co cn co co M o σN M Co co oo o cπ O M Co cπ M cn cD co cD Cn M Cπ cD Cπ M co ∞ M ιt- o co M cn cxι o co co co o ιf- M Co co o co ∞ co co --j cn M θ cn co ιt^ M CD M cn cπ M ∞ M M co cΛ c^ A t- i - i -' i-' i-^ >- Λ i-^ μμμμ i-' l-' i-' i-' i-' t- i >-> i-' I-' t-> t-> 1-^ i-> - 1 I-' MMMOOOOMMMMMO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO cpooooooooooooooooooooooooooooooooooooooσooooooooooooooooooooo CO M M M M M ιt- CO ( J CO CO CO C CO ιI^ ιt- ιf- ιt=. ιI^ ιt-- ιf- ιt- ιt- ιts. M M M M ω Cπ cτι OO CO CO --- M CO OO Cn ιt- ιt=- c/l --J M M M M ω M -J C M ιt- ιt on cn CO O O CO -J M M O M C CD ιt- CO Cθ ' cn M CD --J C cn ιf i . C cn - CD Cπ ιI-. M CD O CD Cn Cπ M M ON ιI^ --J Cπ CD CQ cn C^ cn Lo ι_D M ιf^ -J cθ M cn cn M M ιt- co o^ iβ co M cn cn ιt- o o M ai M --J θ M cή o co co co cD M σN o^ co n ^ ^ co n co oN σ --J c co uN cn -J σι co n c ι oo cn cn n cn OT CO Ω O Ω Ω 3300 Ω 0003 Ω 0003 Ω O O Ω 30 Ω Ω O Ω Ω O O O O Ω 30 Ω O O Ω 300 Ω Ω Ω O Ω Ω 300 Ω Ω Ω O O Ω 30 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ H μ 3 t-3 H μ 3 !-3 τ] !-3 H μ3 ι-3 H H H ι^ μ3 H H H >-3 μ3 ι^ H 3 H ι-3 μ 3 ι^ !^ !^ >-3 >-3 '^ ι-- i-3 ι-3 ι-^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOQOOOOOOOOOOOOOOOO 2222222222222222222222222222222222222222222222222222222222222 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM cnc cTic c c cn ^c cHc onc c c oNcncncnc c cnOTcTi ncnOT ■~JcncncncnσNcncncncncncπCncncπCnCncncncπcnιi-.ιf-ιt- ιt-ιt-ιt-ιfe O CD CX> ~J Cn Cn ιf- (O M M O 3 CD --J θn C l ιI-. CO M M O CD CO -J cn Cn μ^ CO M M O CD m -J Cn Cn U^ OΩΩ333Ω3. 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CO -J it» M CO CO CO M M CD O M W Cn CO CO CO O O --J --J C CO CO it% CO M <-N --J m co M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M Cn CO ^ cn cn CJl ιt- M M lj M CD CD O M M CO M M M CO M M C CO M M M M M M M M O O CO -- CO ^ OO OD -J CO -J ^ CO CO CO -J CD C^ m n co M W ιi-ι n ιt»- M cn M M ιfe D ιfe c ιt- o --J CD --J cπ ιf» c M σN>Cn θ M θ M -j --j cn o3 M ιt- m co co co -~J CD Co ι ι cn Cn θD uι CD ιts. co cπ Cπ co M --J cD θ Co --J o cθ ιt- cn ιt- cπ co M --J M M Co co m O C0 ιt- cn O C0 C0 O C0 C0 cn C0 CD M CD M ∞ ιf- ιt». ^ M M ιt s - --J M C0 CD U3 O σi M Cn cn M σι C0 M M O ιt^ 73 c I 1 I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I 1 I I I I I I I I I I I I I I I I iD co ∞ o j- ii-j- ui Ti σi 'J -J ω ω -J ^ J co co -J ω φ CD ^i o M ui ui ω ω M μ M ih ω ω fc ω ω π iJ Oi -J ui i n oN ω ifc i oi M i ii- Λ n w oi m m cn c^ cn --- ιf- oπ cD uN Cn co ιt- M θ M cn --- ιi-- o --J θ Cπ co -J M ιf- θ ιf » co cπ M cxι cn ιf^ to ιf^ M ιf- M O --3 Cn cn M C0 C0 C0 ιt- M O C0 CD M O -4 C0 ιt^ O C0 --J U> M C0 M lX) 00 Cn ιt- cn ∞ cn M M CD Co M σι cn σι Cn --j co cD Co --J co cD M σN CD ^ co θ M M --J un θ M co M θ cn -- Cπ cn ω -D Cπ u t-' t-^ i-^ - 1 i- 1 t-' t-' >-> t-' l-^ i-' ^ - i i-^ -' >-> l-> i-' i-' i-* i- i-> -> i-' l-> l-' l-' t~ J l-^ H> i-' t-' t-> t-' t-> l-' )-> l-' t-> l-> ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo M M CO Ij j ω M M CO M M M M M M M M M M M cn -J M co -J O C0 Cn C0 -J ιt- C0 CD O U3 O M O C^ CO --J Cn -J Cn -J M CD if i CJ cocncn-J--J-Jcτi-~-cnu σ>cocnσN---cocoo cncn∞cncn--J-J 0ΩΩ333Ω3Ω0Ω0003000ΩΩ00Ω3300Ω00Ω3ΩΩ000Ω3ΩΩΩΩΩ3ΩΩ000Ω03ΩΩΩΩ0003 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ H ι3 H β ι3 β β H H ι34 H H H H H j β β β ι3 H ι3 H U β β β H ι3 ι3 ι3 H β H β H H H H H H ι3 H H ι3 H H H H H H ι3 β β n β β OOOOOOOOOOOOOOOOOOOOOOO oooooooooooooooooooooooooooooooooooooo 2222222222222222222222222222222222222222222222222222222222222 MM MMMMM MMMMMM M MMMMM M MM M MMM MMMMMM M M M MM MM MMMMMMMMMMMMMMMMM MM M M M 7J-J -J--J--J-J -J--0 --J--4---J --J--J -J --J--J ---J --J-J-J--J C0 CJ M M M M M M M M M M M M M M I-' M M M M M O O O O O O O O O O C0 CD CD CD CD C0 CD CD CD CD 00 C0 ) C0 C0 C0 G000000D --J --J --J -J --J -^ -^ μ θ φ ffl i cJi ui ιiN ω w μ o Φ (B ^ m ϋι ^ ω μ θ co -j oι αi fc J w μ o φ co J oι cn fc ω w θ φ ω 'J oι αi ιi- u Ω333Ω3ΩΩ.Ω0ΩΩ3ΩΩΩ0ΩΩ30Ω0ΩΩ3 OΩΩ3ΩOΩΩ3 Ω Ω Ω O Ω Ω Ω ω Ω Ω O Ω Ω ΩΩΩΩOΩΩ3ΩOΩ pa EC EC N PJ O O to pa σ Ω to pa CO pa > B pa O Ω to pa BonW pa OΩΩtt) pa ΩΩtύ M M MMM H3 ι-3 π3 π-i 3 h3 πd d hd iΛ ω /- ω r j . ω Ω Ω Ω Ω . Eα EC iD 93 >D ^ ^ ^ ^ ^ ^ :D Ϊa ^ !D p3 ^ :M ^ ^ M KI M H M M tr , lr 1 f lr , f <ι .<; .<! . ^ ^ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω O O O O O O O ^ lD ^ ^ ^ ^ pa pa pa ^ O O O O O O O H Ha H S i^ H M lT H M t M M M tfl tD to tfl ω tD to to ω tύ tύ totD to tfl ω tα ω tD ω ω M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M θ θ θ θ θ o o o o o o co cD CD Cθ co cD U3 Co co oo oD cxι co --j --J -- -J cn c Λ C3N cn cn cπ cn uι cπ cn cπ cn ιto CO c CO C0 C0 C0 CO M M cn -J -J Cn M Cπ CD C0 M m CO MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM i ^ u ui fc ii- ui i m i j o o μ o o o co co φ o o μ M uJ fr w w u w o o Φ H o o o μ o w o o μ ω uJ ω M O M H O I m μ n j- UI Tl ^l O -J M ItO lO -J i^ ^ Λ O O Ui -J J IO tn ^ J Js. P 1S--0 CO M --O ιt- --J --J Cn cn on CO M u CO OJ M CD CO CO Cn θ tt- ιt- OO CD O Cπ Cn θ M m co cn -J uJ ιf- --J ιt=- M <-D -J Cn co o --J CD CD θ cπ cjι --J Cn co w -j ιt- υi M Co oD θ cn --J c^ CO CO CO CO ιt» Cn --J 03 ιI-. CO Cπ O M O C CO Cπ cθ CX> n CO M M ιt=.0030 <£> --J O -J CO --J 73 i i i i i i i i i i i i i i i i i i i i i i i 1 1 1 I c M M M M M M M M M M M M M M M M M M M M M M M M M M I 1 I I 1 I I I I I I I M I I ~J CXl if» Cn if- C0 C0 C0 M O O M O CD O O O O CD C0 it- Cn -- C M O CD CD CD CO C Cn Cn Cn -J -J ^J -J O CO CD m co oo cn cn cn cn cn o cn M M M Cπ M Co -j M M Cn cn cΛ J O to ιf- C0 C0 C0 ∞ C0 Cπ 00 CD --J O C0 -J CJ cn --J M ιt- Cn M M M CD cn CD J-> C0 M -J O ∞ Cn CD M C0 CD M M σι CD M CD 0n M M M M M M M M M M M M M M MMMMMMMM MMMM t-' t-' l-' ^ t-' t-' l-' t-' i-* -> *-• -* >-> t-' t-> \-' \-' -' }- i t-> t-> -> h- I-* i-> -* O O O O OOOOO O O OOOOOOOO O OOOOOOOOOO OO OO OOOOO OOOOOO OO O OO O OOOOOOOOOO O OOOOO O OOOOO O OOOO O O OOO OO OOOOOO O OOO OOO OOOOOOOO OO OOO OO OO OO OO OOO ιt- cnσ->--juncn cn -ncncπcncnι!^ ιt- ιt»!t- ιt» ι!-- !t ^ M M M M M M M M M M M M M M u O 0a M CD 00 ιt. o cn ιf » ιt^ CA ) CD M O U ) 0n --4 ιt- Cn ιf i M M M μ- » 00 --J O M C0 CJl CD 00 CD -J -^ U1 CO U3 Cn --J CD CXl M CO O O CO M C Cn M CD C» M CJl Cn ιts- CO θ ω oθ O OO M O CO M M Cn M Cn ιt- 03 -^ Cθ M CO C CO O O Cπ Cl cn θ M Cn M CO cn O ιt» Cn M ιI-- CD ^ ω --J ω CD CO M CO CO ιt- cn Cπ CO -J ιt- o M cn — J -J cn -J cΛ cn cn co cn cn --J cn cn cτ^ co cn σN --] co cn co cn cn --J co cn σι --4 cn co c^ O 333 Ω 3 Ω Ω Ω O O Ω 3 Ω Ω Ω O Ω Ω 3 O O O O O 'O O Ω 3 Ω O O θ a Ω Ω O O O Ω 3 Ω C0 Ω O O O Ω 3 Ω Ω Ω Ω O O Ω 3 Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ Ha μ 3 μ 3 ι-3 H H >-3 ι-3 ι-3 H μ 3 '-3 H 3 H !-3 ι-3 H3 ι-3 ι-3 H3 H '-3 ι-3 H ^ μ 3 H H ι-3 μ 3 μ 3 !-3 f-3 H H μ 3 ^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOQOO 22222222222222222222'22222222222222222222222222222222222222222 i-> l-' l-' t- Λ t-' l-> i- i t-' H i t-* t-' t- i l-> )-> i-' t-' )-' l- i t-> -' h- i t- Λ i-> i- }-> l-> l-' t- > i-' t-' t-' t- i i- i i-' -' t-* t-' \- i t-' M M M M M M MM MMM MMMM M M -~J -J --J --J ^ --J --J --J -J --l --l -0 -J -- -J -J -J - -JJ --00 ---JJ ---~JJ --JJ --JJ ----ll --JJ ----ll ----ll ---~JJ ----JJ ----JJ ---^J -----Jl --JJ --JJ ---JI ----JJ --JJ ---JJ--JJ ---J]----JJ ---JJ ---JJ----JJ--JJ ---JJ ---JJ --JJ -~JJ --JJ --44--JJ--44 --JJ--~JJ --JJ --0J -~JJ --0J -~JJ --JJ CO CD CD CO CO C0 C0 CO C0 CO C0 C0 C0 --J --J --J -J --j -j --j --j --! --JcncnoNcτιcn cnσ>cncncncncncncπcncπ cncπ cπcπιt^ M M O CO CO ~J cn Cn ιf- C M M O CO CO ~J cn ^ ω ι μ θ Φ co -J oN n ι-. ω M o φ co i oN π ιi- u M μ o iD Cθ i oN θi fc ω M μ θ co ~J m uι ^ U M O Ω 33 a Ω 3 Ω Ω Ω O Ω Ω 3 Ω O Ω Ω Ω Ω Ω O O Ω Ω 33 Ω Ω Ω Ω 0 Ω Ω 300 Ω Ω Ω 0 Ω Ω 333 Ω 3 Ω Ω Ω O Ω Ω 3 Ω O Ω O Ω pa EC EC N t?d O Ω to pa tO ^ a Ω Ω to pa N tύ D Ω tα pa H H D n tS pa EC EC tSl M O Ω -0 pa Ω Ω tO M M M M M M M M M M M lr' lr , lr ( pa pa pa pa pa pa pa pa pa pa pa pa pa pa H M H M M H M tr 1 lr 1 !r , f !r 1 f f ir' f M W H ^ i» ^ ^ ^ ^ po ^ ^ !Λ !D tr < lr< !r rr l tr l tr ) l→ lr l f l→ G G G Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa ^ H M tO M M M M H ω ω ω ω ω ω ω ω ω G G G G G G G G G Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω ^ ^ ^ ID ro tD tD tD tD tύ tD tO tϋ tD W tϋ tO tD tO tS tD tO ID tύ ro K MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM ∞co∞-j-j--j--j--j-j-j-j--j-j--jcΛcncncncncncncnCncncncnCπι^ I I I I I I I I I I I I I i i i i i i i i i i i i i i i i i i i i i i i i i i i i i I i 73 I I I I I I I I I I I I I I I I M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M -> M M M M M M M M M M M M M M M c — J OO Cn CO it- CO M M M CO CD O CO -J CO OO -J -~4 CO CO ιfϊ. Cn cn cn cn -J M M O O CD CO CO CD O M M M M M O O O CD -J oo -j cn cn cn — J -J co cn -J Cn cn cn — J —J m co -J Cn --J CD --J co cD θ cn --J ιi-- M ιfe CD M Cθ ιfc M ιt- co --J M Cπ --j j^ cn M Cn co Cπ -^ M ON -J CO CO — J Cπ Cn M C^ Cπ CO M O Cn --J ιt- O ιfc Cn co θ O C ιI^ Cn M M CO M ∞ ∞ Cn M Cn O Cn CO ιt- O CD M -J Cn CO --J O to M CTi CO — l cn M Cn M -J Cn cn M CO M cn --- σ^ ^ M CO Cn CO ιfi M ιf^ ιt». --J CO M M CD CO -- C CD CD O C ω MMMMMOOOO M MM I-' ^ i-^ i-' ι-' i-' ^-^ ^-' ι- L ι-' o o o ^-> ι-' l-• O O O O l- > : I-' t-' - 1 1-^ H' !-> t-' t- i i-' i-' t-^ i- i V-' }-> l- i t-' i- i OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ■t-it»cnW Cn cO CO CO U M co M cn cn CO cn en -J --4 -J cn --J cn cn cn co cn cn ^ cnco cn (Λ --J cn cn cn cn co cn cn --J --J cn cn on cn co cn — J co co cn σN cn co cn cn --J --J --J cn ---Jcn cn cn co cn cn — .! cn co cn co cn Ω Ω 333 Ω 3 Ω Ω Ω O Ω 03 Ω O Ω 03 Ω Ω Ω Ω O Ω Ω 33 Ω Ω O Ω O Ω 0300 Ω Ω Ω ' O Ω 033303 Ω O Ω O Ω Ω 300000 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa i- ^ H i-3 H H rt H H 3 H H H i-3 H H H H H3 i-3 H H i-3 i-3 H H >^ H H H H i-3 i-3 ^3 3 H >^ H ^3 H t^ H H3 OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 2222222222222,222222222222222222222222222222222222222222222222 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM ∞ co ∞ oo co co co αi ∞ oo oo oo co ∞ co co co ∞ ∞ oo co oo cD co co co Cn cn cπ Cn ^ ιts. ιt- ιfi ιf- ιfϊ. ιt- ιt- ιi-. ιt- co co Co co ω co Co co co co M CO M M O CD ∞ -J cn Cn ιI-. ( j j M M O CD CO ---4 CTl Cπ ιf- CO M M O CD CO -J cn Cπ ιf- CO M M O CD CO --l cn C^ 0 0 0 Ω 3 0 0 0Ω Ω 0 Ω 0 3 Ω 0 Ω Ω 0 0 Ω 3 Ω Ω Ω 0 0 Ω 3 3 3 Ω 3 Ω Ω Ω 0 0 Ω 3 0 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 0 Ω Ω 3 Ω Ω Ω Ω 0 CO pa B Pl D fl W pa σ O Ω tfl pa Ω Ω tO pa EC EC tNi M σ Ω tO SG N tO tO α α Ω tύ pa pa O O Ω tύ M M M M M M M M M <<<< ΩΩΩΏΩΏΏΏΩM M H M H M M M p a p3 pa pa pa pa pa pa μ ^ μ a ι-3 3 ι-3 t-3 ι-3 H 3 μ 3 3 Ω Ω Ω t-' lr l lr t- , t SEEe r t ! t t < H . ^t < t t ι t , t< tτ' f tr 1 lr , tr l lr 1 tr< pa pa p pa :D :D ^ ^ !D !D :D :D ^ ^ ^ ι^ ^ ^ ^ t , G G G G G G G G G B B B B K B B Ir' t l t< t l t < t < t < O θ n tl (a n Q Ci n Q O ?l J] ?l ?l » !ll !S !ιl lιl ?1 5 B κ; κ; κ: G G G G G totDtotDωωωωtDtDtoωtDtflDBrDraiDtotom MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM o co co co co co co co co co co co co co co w co co co co co co co co co co co co co co co co co co co co co co ω Cn Cn Cπ Cn Cπ ιt^ ιI-. ιJ^ ιt- ιt- ιf- ιI-. ιt s . ιt- C ω C C CO (J Co ω M M M M M M M M M M M M M M M M M M CO c CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO M M M M CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ι- m oι U ι- M ^ U M U u ω W cΛ ^ co o θ Φ o m ω j m J ijι Ui Φ θ o μ M ω M fc ιt> M H o o μ o o μ μ M i μ o (i) Φ Φ Φ μ w μ co -J Cπ Cn M M ιf- ιf- C --J C l CD u^ --J Cn ιt- Cn M cn Cn ιt- O M ιfc Cn M CO M CJl M M C M M Cn M M M M CO CD M Cn ι^ O CD M CO CO CO Cπ θ CO CD CO θn en M CO M CX> O ιfs- cn CO OO M O CO OO --J M M M CO ιt- CO O --J cn M CJI O M --J Cn ιt!. C^ M -J --I M CO M M Cn O CO ιfs. CO CO CO ιts. O M J-. -J CO O cn J CO M -J CO CO tt- ιf- ιt- ιt» C^ m co MMMMMMMMMMMMMMMMMMMMMMMMMMMMMCOCOMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM cπ co ιt- cn cπ o Cn cn ιi-. cπ -j cn cn cn --J — J cn cy> ιf>. cn ( 1 cπ M Co co cn cn ιt=. ι^ m m O Ul fc Ul uN M uO CO O CO l en ιfs. CO O CO ∞ M CO --I ιt!. CO CD Cn CO CD M Cn M CO ιt- OO M Cn ιf» M cn M M --I --J M --J CO ιf- M CD M Cn cn M M C --J Cn Cn CD O M Ul M Cn it- C it M CO Crj ON CO ω M Λ ϋl LJ O IJl M * M m l>) 0 (Λ ι (j m ϋ1 Uι ω θl O U n J l U μ o ω W Ul ~J N) Ul Φ ON -J * O μ φ 73 1 1 I I I I I I I 1 I I I I I I I I I I I I I I I I I I I 1 1 I I I I I I I I I I I I I I I I I c 1 1 1 1 I M M M M M I I M M I I I I I M M M M M M M M I >-> I- 1 -> -> MMMMMMMMMMMMMMMMMMMMMMMMM cn ιC- CO M CO CD O O -J CO CO OO CD O O O ιf- CO CO M M M M M SO O M O M M OMMMMMMOMMMMιf-C0C0ιt-ιJ-.ι cn--J--Cn--Cncn m u μ Φ -j ' i o ∞ fc H Φ W Ln m i o Λ oi ft o p i ω o oi M oi u o ω W i ω M ω j ^ j φ io o o N M U μ it. it' i- u o co μ ω m M to M C0 Cn M M O M C0 M Cn -J M C0 M C0 ) M O Cπ ∞ ∞ en M cn O C0 C0 CD O O ιl-. CD M C0 --l cn M C0 C0 ιts. O C0 CD O M Cn cn C0 ω co Cπ -J CO M M M O CO Cn (^ CD θ CTι CO ιt» -J M M Cπ --J <-n M --J CX) ιt- C M M O --J ---j α ) CD M M Cn cn C^ ιt»-M CD CO CD h-> h-> )- > t-> i-> t- 1 i-' t-' t-' l-> t-> )-> b-' l-> l-> t-' i- > t-' t-' >-• ^ i- 1 i-' i-* -> l-' t-' i- Λ h-* Λ i-* H> l- i t- h-' t- 1 t- i l-* ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo lo co ω M M oi ui μ si ui ω m ω d^ ∞ CJl ιt- M Cπ cθ ω ιl-. ' c Cn U3 ω Cπ θ CD O O -J M CD CO Cn -J --J ι£- M Cπ Cπ C0 0l C0 CD O M 03 M cn --J C0 cn -J C0 CO CD W C0 -J C0 M »f- ιfe CD --l C0 ιt- ∞ C0 M Cπ M M O C^ cncocncn-Jcooocn i c ι co cn Ω 0 O Ω 3 0 0 0 O Ω 0 Ω Ω a Ω Ω Ω Ω O 0 Ω 3 Ω Ω Ω 0 0 Ω 3 3 3 Ω 3 0 Ω Ω 0 O Ω 3 0 0 Ω Ω O 0 Ω Ω 0 O Ω 3 0 Ω Ω 3 Ω Ω Ω Ω O pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p H rf β 4 β β ^ fJ H β HJ 4 β tJ ^ β ι3 ri 4 β H β 4 ι3 H rf β H 4 ι3 β H H ^ ^ H i3 ^ ^ H ^ rf 4 ^ H H ^ H ι3 ri H ι3 ^ ^ ^ ^ H H ^ H O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 23.22222222222222222222222222322222222222222222222222222222222 I-' * t- t-> \-^ l-^ t-' MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM CO CD CD CO CO CO CO CD CO CO CO CO CO U^ CO CO ∞ ∞ rø CO ∞ CO CO CO CO OO CO ∞ ∞ Cø ∞ μ μ μ μ μ o o o o o o o o o o Φ Φ Φ Φ ffi ii ffl ω c co ∞ ∞ ω co i sj j i j i i oi ffl m ii ffl oi iΛ iΛ m cn ui ϋi ui W ui ui ιt- ω M M O 5 C0 I cl Cn ιf- U) M M O CD C0 --l cn Cn ιf- ω M M O Ui C0 -J cn Cn ιt- C0 M M O CD ∞ Ω Ω 0 Ω Ω 333 Ω 3 Ω Ω Ω 0 Ω Ω 30 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 300 Ω Ω Ω 0 Ω Ω OΩOΩΩ3ΩOΩ O'Ω Ω300ΩΩ0ΩΩ3ΩΩ Ω tO pa EC EC INI W O Ω tO pa ΪE N H H D D O tϋ pa tO H O Ω tO pa ΩtO pa ΩΩtO pa αOΩtύ pa OΩ M M M M M M M t→ tτ' tr 1 tr< tr< l→ pa a p p a a pa a H H3 3 μ 3 3 t-3 ι-3 i-3 H ι-3 3 H Ω O Ω Ω Ω O Ω Ω Ω ω ω κ; κ;ι- κ; ^ ^ ^^ | ^ ^ ^ ^ ^ ^ ^ ι-< H^ μ μ < fr , t- < tr < r , lr < - , rr , f w oc ωωω Ω ΩΩ ΩΩ ΩΩ Ω Ω ΩΩ^ ^ ^ lD jD iD ^ jD iD jd jDiDσσαGα α α GlD ^^ tD ^ ^ ^ pα ^ iD ^ ^ rao D oco dtD -otDcoωtDt roo ω MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM tt- ιf=. ,f=. ιt- ιt- ιl-. ιl-. ιt% ιt- .t- lf- ιl^ ιt- ιt- ιt- ιt- ιt- ιl-^ M M M M M M M M M M M M M M M M M o o o o o o o o o o o o cD CD CD Co co cp co co co co co co oo co co -j -J -J -j -J — ι -J cn cn cn cn cn cn cn u~> cn cn CO c CO CO ■ ~J -J --J θn cn Cn ιt- Cπ ιt- CO M CO M ιt=- ιf- M M M O M O M O O O M M M u Cn ∞ -- Cπ Cn ιt^ ιt=. ιf^ Cn CO M C ιI-. M -J ιe' Cπ ιf. Cπ M cn M O -J Cn θ CO M -4 M --l CD CO — J Cπ co θ --I M O CO O CO C CX) O Cπ θ ιI^ CD M CD ιf' it- cn CO O --J ιts- M ιf=. M CO M M CO Cn ιf- CO Cn ιt- ιt-- Cn CO M ιt- M ιt 5 - M CD CO --! CO CO Cn CjJ O CB Cn --J M ιt » - M CD Cn θ C ιt s . ιt- C M CO cn ^ c^ c M CD θo cπ ιt- --j M c M θ ιf^ M θ (J Cn c M on c -J θ ιt^ cπ cD CD αN ijθ ιfc o co co c^ m MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM co oD -o α^ c cn cn ιs. cπ cπ cn cn c »^ cπ c --ι co M θ 3 M θ D c --J co D t co co cD CD M M ω m M M M O O ιfe Cπ Cn σ^ Cn CO -J CD Cπ cn Ij Cn M M CD Cπ CD ιt^ M O CO ιf- c^ ---M' --J M ιf- CO M C^ m w o ϋi ϋi m ω -o o i O Φ o μ φ ^ co ^ m ω m φ co o μ o o m i o m ib o ^ m ^ J m Φ ω o μ o Ln co ij φ φ ∞ j φ φ μ ^ ω cn ιfe ui ιP> ^o co μ wμ ^ wμ o* i m n ^ M ιb ω mθ3 ι& ιi- wo3 φ -) ωω l3μ o -) θM MΛ ιi- >J iiD M cn cn if- o co M — J M Co cn M M if- — J —l cπ I I I I 73 I I I I I I MMMM I I I I I I I I I I I I I 1 I I I I I I 1 I I I 1 t I I I I f I I I I f I I I I I t I I t I I c Cπ it- CO CO if. it. M O O O CO -J Cn its. Cπ Cn it- M O M O O M.M M M C0 M CO Cπ C0 ιt» C0 M M C0 ω ι!-- -J C0 Cn cn -J Cn ιte ^ Cπ Cπ Cn Cn θN U3 O0 ∞ m CO M M ιt- Cπ cD Cn --J C» M CO CO CO CO M Cn c^ Cn --J M Crι M ιf- O O CD CO ιf- O Cπ θD CO CO --J ιf- M -4 cD ιts. OD OO OO M cn CO CO Cn 3 θ --J ιI-. ON --J CO M M CO ---! ON CO O ιb M Cn ιI-. U^ to cn M OO CO M M ιt- Cπ -J M M CO M Cπ ιt- CO Cn cn M Cπ CO O --J CO -J CO Cπ ιt- M Cn CO --J CO -— ! M --J M O --J CO it- M M CO Cn O M O --I CO cn CD M -J CD CO CO CO O CO CO co M M M M M M M M M M M M I ,_, | _ι f_i ,_, !_ ι t-" b- 1 i-' t-^ t-> ^ t-' b- 1 t-' -' l-^ l^ i-' i-' l-' l-' t-' t-' l-' l-' OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO.'OOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO O-O OOOOOOOOOOOOOOOOOOOOOOOOOO C0 C ιl^ C0 C0 C Cn cπ ιI^ ιt- ιt- C C0 CO C0 C0 C0 M M M M M M M M CO CO C0 C0 C C0 C0 M M C0 CO C0 ω o ω μ α) σι M θ Λ θ o ϋι LJ Uι ω μ Ln μ oN u μ π A, i o ω h ' j ϋi -j ^ φ co ui μ o w o-j ui o co ω c- ω w uj υj μ o μ cπ σi μ μ ω μ μ o σi CD CD M O -J M M Cn CO M CO Cπ C CO ιI^ Cπ CO C CO Cn cD CO C Cn cn O M M CO M O M M CO cn CO --I O M --l M O M O Cn ∞ D CD W M C u^ O O D Cn σi M i^ M C ∞ O Cπ O D Cπ i& CO CO iI-. ω cn cn o3 α^ cn --J --ι -J N -- cτι σN c^ co cn cn -J co u-ι cn cn c c (Λ σN Cθ c c^ Ω Ω000333Ω3 Ω0 Ω00Ω 300 Ω ΩΩ Ω0Ω 00030000Ω00030000Ω2 Ω 00000 a 000000 Ω 3 Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo 22222222222222222222333333222222222222222222232222-22222222222 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M Cσ CO CO CO <O CO CO CD CO CO CO ■~j -o -j --] --ι -4 cn cn cn cn cn Cn it- CO M M O CD CO -4 uN Cn 3 O Ω O Ω Ω Ω CO Ω Ω O Ω Ω CO Ω O Ω Ω O Ω O Ω Ω 3 Ω Ω Ω O Ω Ω 0 Ω Ω 300 Ω 300 Ω Ω 00 Ω Ω Ω Ω Ω O Ω Ω Ω 03 pa B'O O tD pa Ω to pa Ω tO pa Ω Ω tO pa pa pa o D Ω tύ pa a a Ω Ω α Ω Ω tO pa N F1 D M M M M M f ω cQ ω ω ω cΛ 22222222 Ω Ω Ω Ω Ω θ ω co to ω ω ω < < < < Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa pa H H H H H H H M t H rr l t-' IT- M M H M K FJ FJ H M M W M K H KJ ^ HCJ K H H G ^ ^ !D ^ !D ;zi i-3 ha i-3 3 H H i-3 t-3 M W W W W W pd ^ ^ p3 ;D :D f f f ω ω tD ω tD ds ω ω rø tD ω ω to ω ω tα t ω ω MMMMMMMMMMMMMMMMMMMMMMMMMMMMM MM MMMMMMMMMMMMMMMMMMMMMMMMMMMMMM Cπ Cπ cπ cπ cn cπ cπ Cπ cπ Cπ cπ cπ Cn Cπ Cπ ιf- ιtϊ. ιt- ιt- ιP- ιt- ιf !t M M M M M M M O O O O O O O O U3 CO CD CO CD CD CO C0 00 03 CO CO -0 -~-J -J --J - -J --J cn cn c l Cn Cn cn cπ Cπ ιf- ιf- J^ CO c CO M M co co co co co co co co co co co co co co co co co co co co co co ω CO CD CD O O O cn Cn iI-. if- C M M M M M M M U ) CO M M CO it- Cn M CJl M M M C l O CD CO -J ∞ M Cn ιe. OO CO M ∞ ω ∞ M m MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM MMMMMMMMMMMMMMMMMM CO -j co ω cn --o co co M θ cD 3 θ CD θD --ι co ι- cπ cn cn cπ co ιt- cn cn cn cn co o cD CD - co -^ I m o ui i (yι σι ^ w oι w *. Ln o o uι ϋJ l_ ^ i μ o w ω *. ιi- ΛN -J ) W c ,μ w m ii- i μ μ ui i φ j- ui μ cn o uno o co fc μ cn ϋj φ co φ uj μ μ ii- M Λ m CD M CD ιi^ cπ cD C D cn ∞ o --J cn Co cn cn cD Cπ co ιi-. o co cn ιf» M cn M co M M Co M ιf» co ιti Cπ ιl^ Cn cD -J M C0 CD M O Cn --J cn M O C0 C0 M O Cjl C0 ιt^ C0 M ιts. C0 M ιt' M CD M M C0 M C0 -J CD Cn C0 M cn M 00 σN M C0 O U^ 73 I I I I I I I I I I I I I I I I I I I I I I I I 1 I I I I I I I I I f i l l c if- M M CO CO CO M O O O M C M M M O O O O O M M Cn it- if- M M CO CO M CO CO M it- CO M M CO Cπ it- CO M M CO M M O O O O M Cn cn if- m co on cD C ) CD Cπ --4 θ co cα M c ι -J θ Co co co cD -^ --J Cπ --j ιf- ιt=. cn ∞ --j co co co co j^ cn cD Co o co oo co cn M M ω M co c j i M cn o3 cn ιf^ -J θ M M -J Cn|-- j oo M co co cπ uι o cn cn co cD cn M CD ∞ to Cπ M M CO CO Cn --J σι M CO CO CO Cπ cπ CD ιf' O M CO CO Cπ cD Cn M CO M ιt- M CO -O M M ' ifs. ω ∞ cn Cn on Cn ιt- O M --J M ιt- M -J M -J CO ιf=. Cπ --J CO cn M C O ιt- CO OO CO M M M M M M M M M M ]-^ i- i i- i i- i Λ i~ i i- Λ l-' i-' - l- )- i i- 1 -' t-' ^ t-' -' l-' OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO M M M M M M M M CO CO M M M M M ιt- C C M Cθ C C CO M M M M M M M M M M M M M M M CO CO CO CO CTl Ul Cn Cn CO ιt- ιI^ ιt- M Co ω oι μ o ϋJ U io o ∞ t. o -J φ σi ιi- oι M *. u ιo μ μ oι μ i co co cn W h ' Cn -j cji it- »-. oo cn co cD Co M cn CD M CD --- M --J M Cn co co --j M it- O M cn cn o cn co CO CD ) iχi Cn cn ι^ -4 Cn θ CO CX ) CO CO CD M O ιI-. C l -J CO CO O CO M M --J O O ^ M CO -4 CO ιI^ Cπ cD OO M M Cn ιt- OO Cπ co --l CO C0 01 CO O M ιf- O ιt- O CO O CO M -- ] 0 -0 ∞ M M --jcocncocricn— Jcncncncn∞cιcn-Jcncyιcocncn--4-ocncocncn--Jcnc^ 30 Ω O O θ a Ω tθ Ω Ω O O Ω 3 Cθ Ω O O Ω 3000 0 Ω 3 Ω Ω Ω O O Ω 30 Ω Ω 30003000 Ω O Ω Ω a Ω Ω Ω Ω 00033 Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa μ3 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa OOOO000O0O0OOOOOO0O0O0O00O00O00P30OO0O00O00O0O0OOOOO00O0OOO0OO 2222222222222222222222222222222 22222222222222222233332222222 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O O O O O CD CD CD CD CD CD CD CD CD CO CD CO CD CD ID CD CO CD CD CD CD CD CD CD CO CO M M M M M M M M M M M M M M M M M M M M O O O O O CD CD CD CD CO CD U3 CD CD CD ∞ ∞ Ca cθ CO CO CO CO Cθ α) -J -J --0 --J M O CD CO -J cn Cn ιf- CO M M O CD CO -4 CΛ Cn ιt- CO M M O CD OO -J cn Cn ι6. CO M M ιt- CO M M O CD OD -J cn Cπ ιf=. CO M M O CD CO --J cn Cπ ιt- CO M M O CD CO -J cn O O O O O O O O O O O O O O O O O O O O O O O O O OjO O O O O l-^ -' Λ l- i -' -' hS ^ ^ l^ L-'-h-> t- ^ i -> ^ ^ t-> -> l--> t-' t-' i-* l--> i-> \-- i O O O O O O OO O O O O O O O O O O O O O O O O O-O O O O O O -j pc [u pr * "-T- " * xι "ij " ic ,-i-j ~x * iii-j " ir " i-G p-i * xι * xι " .r-i i-c jrc " -∑ ~ i "" i-t "e " -." -i χ ;χ χ ;χ ;χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ χ ;χ: ;χ χ χ to to ω tα ω to tθ rD θ3 to to to to tD tα ω to to tD tD ω M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO M M M M M M M M M M M M M M M M M M M M cn cπ (_n cn cn cπ cn cn cπ cπ cπ cn cπ cn cπ cn cn cπ cn cn cn cn cn cn cn cn cn cn cπ M O CD ∞ --J cn Cπ ιP- ( jJ M M O CD θO -J θ Cπ ιf. C M M O CD CO -J cn Cπ ιt- C M M it% it- it* il-. if- it- it- it- it- it- C CO CO C C C C C C W CO c CO M M M CO CO M CO M M M M M M M C CO M CO CO ιf» ιt- M M CO ιt- M M ιt- ιfe CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO TO cn cD Cn cn cD co ON --J M CD Co cn co its. M if- M M ' M Cn M cn cn co co M M M Cn it- W ιt- M C0 M M M O C0 M M CD 03 C0 0n 0N Cn ιf^ C0 C0 ιf» Cn U3 C0 00 C0 cn cn C0 C0 Cn C0 --J M O cn C0 --J M ιt- ιfe M C0 -rJ C0 00 C0 O --4 M cn M --J Cπ CD ιts- C0 C0 C0 Cn Cπ M M Cn Cπ CO C^ M CD C ιt- O ιf>. 0 - C CO Cn Cπ ιf» cn CD Cn M --J M -- ] CD M ιti M M ιf- M M M CO -4 ( -n --J cn σN M Cn cθ CD CD C C0 - ] M C0 -J Cπ Cπ -J Cπ --J M ιt- M cn cn co co fc -J j- m θ M co u N m ιo cn uι co o cci 'j μ ui uN ciι W Φ M ιi- CO M CO CO O O -J Cn σN -J CD O CO M CO O O M -J Cn M Cθ M M CD O O --J -J CO M O it- co cn o M M u O M uJ ~J cn if=- -- o M cn co o o o c3N cn cn co o M cn m co M M M M M M M M M M M M M CO M M M M MMMMMMMMMMMMMMMMMM M M M M M M M M M cn ttv cn cn -J co -j -J —J — J cn if- cn cn co -j I ■ft. it- cn co c M M co M O O O Ul CO cn cD CD M CO M Cn CO CO O CD O M CO co co co — j -— i -J cn co -J cn — - m Cn c Cn O M CO M ifc Cn M M Cn Ul O -J M O CO M M --J --J CO Cn --J O CO it- cn.O CO Cn θ ιI-. M --I M CO CO Cn CO cn CD CD M Cπ C0 M Cn --J O -J M O C Cn cn CD -J CO m C0 M C0 ιt- ιt- -J Cn M M C0 M Cπ C0 CD O cn --J ιt- Cn M M C0 M O M M Cn ιt- C0 --J C0 O M ιt- CO I ιt- --J Cn M ' l M CΛ --J M ιt- ιfe CO C CO M CO Cπ cn M CO -— 1 CO M CO M Cn Cn M CO Cn -O M CO M M Cn — j O -J —i o -J it- — J co cn cn o cπ ιt- co — J cn C M M Cπ co cθ M ιt- co M uJ co o -J -J Cn cπ ι£- co _o M M ιf- co --. ] Cn co co cn co cn 73 c I I I I I I I I I I M CO CO -J cn CO --l CO O ιJ-. M M O M CO Cn -J co cn Cn CO ιt» Cn CD CD CO O -J θ ιI-. CD ^ co cD -4 θo -J cn cn cπ cπ ιt. o o o o o M M ιf» ιf=. co ιf- co σι --J cn cn ιf- cn m cD M θ cn co -J cn cn M co ιfe -J cn cn cn ιf=. co M -J M cn θ ιf- cn --J uJ θ Cn M co cn -j -j -j -j -J cn cn co cπ M -J cn o M O M cπ M O M -J M -J co cn cn O co M to M CO it- CO Cn Cπ M CO — i cn cn cn co -J M cn M cn M M CD O M --J co M co co o ii-. o o uι μ M θ Φ ^ uno -J *. *. co oι o c ^ι m μ o φ μ -. ft -j J uι μ co co cn co cn Co θ3 Co co -J cn cn cn M -J CD θ Cθ cn co ιi-. cn ιi^ M co co cπ M M M ιt- M -J ιI-- CO CO CD M CO CD -J Cπ ιt- CO Cπ --J M M Cn --J Cn CO O M CO CO Cπ --J M M MMMM MMMMMMMMM M M M M M M M MMMM M M M M M M M M M M M M M OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O Ul M m oo co co ιt- CD CO Cθ O CD CO CO CO CO CO CO CO CO CO CO CO OO CO OO CO CO CO CO CO CXI CO CO CO OO CXI CO ∞ CO CO CO σι cn σι o^ <- cn cnco cn o^ --J --J --J oN --J cτ> cn cn co cn cn -Jcn c cn cn cθ u^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO ΩΩΩΩΩΩΩOΩΩ333Ω3ΩΩOOΩΩ3ΩΩΩΩOΩΩ ATOM 32 01 HOH X 32 24.945 14.476 -0.833 1.00 33.94 8 O ATOM 33 01 HOH X 33 33.088 30.207 -5.151 1.00 36.10 8 O > pa Pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa- pj H H H H H H H H H H H H H H H H H H H H H H H H M H H M H H H H H H H H O O O O O O O O O O O O O <) O O O O O O O O O n Ω Ω O O O n Ω O O Ω O n O O O O O O O O O O O O O O 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 22222 22 2 22 2 2 2 2 2 M M M M cn CO fc u M μ D T n T3 T T3 3 n3 i 2 2 2 2 2 2 2 2 f D 'D π3 π3 π3 n3 'D 'D τ3 'D iτJ co SL EC EC EC EC EC EC EC cn pa pa pa pa β i---. O O O O O O o o o o α M O M CO M M M M M O • O M CO O --J cn Cn O M ---J CO it- M M M M M ιf» O O M ιt=' t CO vJ co en co ιi- uι on en O ιI^ CXl ιt- ιt- Cn cn cD Cπ cn c CO CO O CO O CO CD M CD M Co M CD cn ιfs. co cD er. M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO CO CO M M M M CO CO CO CO CO CO CO CO CO CO CO O Cπ ιt- ιt- CO M M M O O CO CO CD Cn tn M -J CD CD CO --J OO CO -J --J CO CD CD CXI CD M Cn Cn M O * μ cή θ fc ! W N W ϋι o^ ή μ w Φ Φ W cΛ U i αι μ ui J uι μ M n cn u u α) μ ^ o ) U o ι m t. co D Co cn M cπ - j -— l oN M co ui μ m Φ u u.oN ϋi m o t ^ φ μ o u M w ij o fc φ t ω co w ω o ui lj w μ ffl ui oN. *. M cn cn -J cn cn co cn cn --J ^ cn cn cn cn co cn cn --ι cn cn cn cn cή cn cn co cn cn — i cn cn cn cn co cn cn -J cn cn cn cn cn cn cn co cn cn ~J 33 Ω Ω 3 Ω Ω 0 0 Ω 3 3 Ω Ω Ω Ω 0 O Ω 3 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 Ω C Q Ω Ω 0 0 Ω 3 Ω Ω Ω Ω Ω Ω Ω 00 Ω 3 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H H H H H H H H ^ H e ^ H H H H H H H >-3.ι-3 3 H H H H β β H H H H H H H H H β β β H H ι3 i3 H H ι3 β ι3 i3 H H π oooooo oooooooooo ooooooooooooooooooooooooooooooooo ooooo oo o 2-22222222222222222222222222222222222222222222222222222222 O O O O O O O O CD C0 CD CD U3 CΩ C0 CD CD C0 C0 ∞ ro C0 00 ∞ C0 C0 C0 C0 --J --0 -J -J --J --J -J -4 -J i m oι ^ ω M μ θ Cθ i m ιn t u M o φ ω ~J cΛ ϋi fc U M μ θ o J cή ι * ω w μ o φ o ή ϋi ^ ω i μ o Φ ro -J m ϋι ^ U M μ Ω Ω Ω O Ω Ω 3 Ω O OΩ 3 Ω ΩΩ O O Ω 3 Ω O O O O Ω 3 3 3 Ω 3 Ω Ω Ω O O Ω 3 Ω O Ω Ω 3 Ω Ω Ω Ω O Ω Ω 3 Ω Ω Ω Ω O Ω Ω O Ω 03 pa to pa o Ω tD pa Ω Ω tO pa EC EC tNi H O Ω 03 pa 03 pa O Ω Ω td pa O Ω Ω tύ pa M M M M M M M M pa pa pa pa pa pa pa pa 3 π3 π3 π3 π3 τ3 !D >-3 >-3 !-3 >-3 F-3 μ3 pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H H H H M H H H H M M φ φ fy φ ?3 t t< * t φ Φ Φ Φ Φ Φ ' ? i Α Α 'X ΪZ 'Α 'Α 'X Φ π W Φ Φ ϊa φ φ . p .d t _r' _ ! _r 1 t ..r ! _r 1 | _r< l _r 1 - .. l _→ l _r , t ..- 1 lr l t- | l .r < t .r , t- , t- , t- | tr , lr l Ω nθ n n n ^ ^ ^ ^ ^ O O O O O O O ^ » 3 ^ ^ 3 ^ n n n Ω n Ω Ω n Ω Ω Q ^ ι ι ^ H B H B H H H M I?l pa pa pa pa pa pa pa. pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa'pa pa pa pa pa pa p^ M M M M M M M M M M M M M M M M M M M M μ μ μ μ o o o o o o o φ Co ai ffi oj -i o co m i i αi co i j ^ sj vj oi oN ή m ffl fl cn cii in oi ui ui i tn ui co co ιta. ιfi ιt- M M M M M cD M θ U3 Co co M Cn C CX) M CD Cn M O cn CO CO M M σN CO (j M O ιI^ O M --J O CO CO --4 M cn CO OO O Cn c^ cn O Cn C0 M αD CD M ιf- M M O ιl^ M CD Cπ cn M O ^ 1 1 1 1 1 1 1 I I O O M M it- CO M M M O M O o cn co O o M M o o o o M M ιis μ μ μ fc φ m M W θ M Φ U 0N *. 0N. Φ M μ uι uι M t. μ μ C0 CD ιt- C0 M C0 -4 it- Cn cO --J CD M M --J Cn C it- CD M M M M M M M M M M M M M M M M M M M M M M M M M M M cn cπ cn cn --J -J co co o o O O M O M O O O M M Cn CO ιt- ιt=- ιt- C ιt- μ μA φ M M oi J μ ui o o o-M co co M CD CO it- co co co cn cn ~j M θ ιf5. CD U3 -J --J C0 ιf- C0 O C0 ιP^ M co cn cπ c ι M M Co oo co ιfc i- i t- s l-' i- J t-> )-' t-' l-> h-' oooooooooooooooooooooooooooo oooooooooooooooooooooooooooo M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ∞ cn ω M θ θ Cθ -~J ∞ ∞ -J σ^ cn cn cn --J cn σN -J -o cn --J cn cn -J w co ∞ -0 O CD C0 -J C0 CD ∞ -4 Cn C0 M Cπ 0-\ .M --4 ιf- O 03 ιt- --J ιt- M ιt=. ιt- CT> ιf^ cn o en -J Cn cn θ ιt- co ∞ co M cn M θ θ ιt- M CD oo ιt- cn cπ co cn ιf- o co cπ --J CD M -J co cn cD cn »^ cn cn cn co cn cn — J c oo on uN -J θN cn θN Cθ σN θN --J uN ) uN Cθ uN c -o --J ^ Ω 0 Ω 0 Ω Ω 3 Ω O Ω Ω 3 Ω Ω Ω 0 Ω Ω 3 Ω 0 Ω 0 Ω Ω 3 a a Ω 3 Ω O Ω 0 Ω Ω 3 Ω 0 Ω Ω a 0 Ω Ω Ω 0 Ω O 3 Ω Ω Ω Ω 0 Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p ooooooooooooooooooooooooooooooooooooooooooooooooooooooooo 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 2 2 2 2 2 2 2 2 h J t—J — ' t—i * ι— * l ι_-^, ^ I— - t— * lM_, t— • t— • t— - h— h I—a * ι — ' t— • (— h i— J ' ^ t— | r-— J r- r— r-—i t— t— • I— • t— • | t_—i t— ' t— * | t_— l * ( r_i h t—j ' | i_—i ' t— • ^— t r-—> \ I —-> t I —-> - t t —-' t < —- i - l I —-' l I —-> - t < —-' t t —-' t I —- i ■ t — - \ t —-> - I — Λ t j —-> ■ l t —- 1 t I —-' ■ h I —-' - \ I —- Λ ■ I —-' l t-—> - i ι —-' cn c onn ccnn ccnn ccnn ccππ ccππ ccππ cCnn ccππ ccnn ccnn ccππ ccnn cCnn ιι!t^ ιιtt»- ιιii--.. ιιii--»» ιιi!^^ ιιtt- ιιii^^ ιιtt ^ ^ ιi^ ιs- ιt- CCOO MM MM OO CCDD CCXXll ----JJ mcn CCππ ιιII--.. ((jjJJ MM MM OO CCDD ∞∞ --JJ oonn CCππ ιιff** ωω MM MM OO CCOO CCOO ----JJ ccnn CCnn ιιffe. CCO MM MM OO CCDD CO --l cn C^ Ω O ΩΩ 3Ω O Ω O Ω Ω 3 ΩΩ Ω Ω OΩ Ω 3 Ω Ω 300 ΩΩ 0 Ω Ω 3ΩΩ Ω O Ω Ω 3 Ω Ω Ω Ω O Ω Ω 3 0 Ω 0 Ω Ω 3 3 3 Ω 3 03 pa O Ω td p o D Ω tO pa pa O O Ω td pa Ω Ω tD pa O O Ω to pa Ω tO pa EC EC INI CO M M MM M M M M M M M M to ω co co ω ι-3 >-3 H ι3 H H H t l t , t f t H t ) t < t H n Ω Q n pa pa pa pa pd pa < < < < < < | r i |r l l→ tr' lr l l7 l l , t < ω ω ω rΛ Co ω pa pa pa pa W tO DO H tO EC EC ffi W K C K H W H H M ta pl H ^ I→ f t 1 ω t ω ω ω ω ω ω pa pa p pa M K H M M H -O H K M W M M W O ID pO pd lD fO pO pO pO pd pO tO G G G G G G G G K! τ3 π3 n3 3 π D I→ lr , lr , tr l t- | lr' lr < G G G σ σ G G σ ?3 JO ?3 ? p3 ?3 Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M o o o o o cD CD CD CD CD CD CD | co o3 θθ oo co θ3 co co --j --o -— 1 -o cn cn cn cn cn cn cn cτι cn cπ CO CO C CO CO CO CO CO CO CO CO CO ω ϊi uι uι u uι uι W Φ o o μ φ W i- ui φ θ o it- C0 M CD if- O M M M M M M M O 00 CD CD O O CD C0 cn --J C0 C0 C0 C0 --4 CD CD CD Cn Ul Cπ M M Cn CD Ui ω o O M W ∞ C^ OD ^ I-' h-' h^ i- 1 t-' t-' M M M M M M M O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M' M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO CO CO U W M W O i oi -J ω j ω ω si ω ω j φ Φ O j φ Co αi o j m iJ O Φ o ω φ Φ ffl φ m ώ i ω o i co co - j φ φ co j φ Φ U ϋJ lj μ it- M ON Cn if » CO M CO cn Cn CD On CD O O M cn O M M O CJl if- CO CD M it- CO M CO CO -O M CO --J it* Cn M M O C^ ui cs w oι co μ μ o tιJ θ oι o θ (jι '' M M io μ μ - ) H θ Λ i (jι ϋι o ω - ) μ ' iB *. φ θ -J oι o co oi φ ιi- μ μ Φ ) JN ϋi -i ϋi M φ Cθ ϋι μ ιπ cn cn oD cn cn -4 cn ∞ cJN Cθ cn cn -J cn cn oι cn oo cn cn --J co cn oN --J co ∞ cn σN θ3 c^ Ω O Ω Ω a Ω O O O Ω Ω 3 Ω Ω Ω Ω O O Ω 3 0 0 0 3 0 0 0 Ω O O Ω 3 Ω Ω Ω O Ω Ω 3 Ω Ω Ω Ω O O Ω 3 0 Ω O Ω Ω 3 3 3 Ω 3 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ μ3 t^ H H H H μ 3 H ι-3 ι^ H μ 3 H 3 3 μ 3 H H μ 3 μ3 H μ 3 H μ 3 3 3 ι-3 3 3 H H H H H H3 H >-3 ι-3 μ 3 3 H μ 3 H H H 3 O OOO O O O O O O O OOOOO OOO OOOOO O O O O O O O O O O O O O OO OO O O O O O O OO O O O O O O O O 222222222222222222222222222222222222222232222322222222233 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M >-> l-> t-' H> )- i )-> h- i t-> b-' t-' > i- i M M M M M M M M M M M M O O O O O O O O O O CD CO CD CO CD CD CD CD CD CD CO CO CO CO CO CO CO -J n cn en cn en M O CD CO --J σN Cπ ιt- CO M M O CD CO --J on Cπ ιt- C M M O CO CO --J cn Cn ιt- C M M O CO ∞ -J cn Cn ιt^ C M M O CO CO -J cn Cπ ιf-. C M M o co co -J cn cn O Ω Ω 3 O O Ω Ω O Ω Ω 3 Ω Ω Ω O Ω Ω 3 3 Ω O Ω Ω O O Ω 30 Ω Ω 3 Ω Ω ΩΩ 0 ΩΩ 33 ΩΩ 3 Ω Ω 00Ω 30 Ω 00 Ω 30 O D Ω tύ O Ω CO pa LSI CO D Ω tO pa pa O O Ω 03 pa MWODΩD3 pa ΩtO pa O M M M M M ! -3 μ 3 >-3 H3 p a pa p pa iD π3 D π3 π3 h3 tτJ |^ ' lr < lr< l→ lr 1 rr < r^ Ki ω to ω ω LO Ol to n jtl ^ ^ ^ ^ P ^ Kl Kl Hl Hj Ki μ ir' μ ^ H H M B B M H B H H H H H H H H H B IS M H M H p3 p3 fd pd O τ3..D fα O ή π θ O O O O O θ co ω c ω ω c ω c μ< H^ G σ G σ G G ω ω cn ϋ- ω ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ∞ co ∞ m -J -j --J -J --J -ι -j -J cn cn cn cn o cn cn cπ cπ cn cn cn cπ cπ cπ c^ CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO ω CO CO CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M c Cn Cπ Cn Cπ CO ifc CO CO CO if- CO M M O M CO M M M cn υi if- CO M M M O O ∞ ∞ CXl cn M M M CO Cπ Cπ ifc i^ CO O cn cn M M --J -J M M O O^ iI-- O CO (jO Cn Cn CO M CO ife Un M W M M CD M M CD M --J il-. C7N M cn cxi --J J^ CO cn CO Cn M CD CO -O Cn cn ιt- M CO CO O CD M CD M cn M CD CD Cn rø --J Cn CD M --J M Cn CD M -J CO CO CX> --- O CO M Cn M Cθ ω M Cn cn M ιt- ιt* ιfc CD ιI^ CO M M CO M Cn θ O ιt- M cn M O CO Cn cn O CO ιt!. OO M --J CO M CD CD OO M O ι^ l-> l--' t-^ h-' -' -' l-' t-' J J -' l-' -' l-' Λ l-- i h-' t^ l--' l-- i l- i l--> -' -> -' l-- i >--' ιt- cn ιt- cn o co cD cx) cn cn -o cn ιt i - co co cn cn cn cπ co co --j cn -J cn cn -J oN - i m co ω ui ^ ^ φ o m -j Λ i u-i oN ON -J ∞ -j oN n M ii- ii- ω ω m Cn M 03 CO ιf» CD CO --J M ιP- ιts. --J O M CD O M ιl^ ιf^ ιf- (Jl CO U1 Cθ σ^ Cn ιt- Cn ιt^ CO co ιi-. M co M Cn co cn ιt- co cn co --J θ M M θ θ C M Cθ --j cn co co -J Cn -J M cn o cn -j ιfs. co ω o M Cθ cn ιt- I π ιt- -- j cø C θ D --J -J ιf- o .c ιf* ι-' CD ιt- ιt i cn Cn o M C c ιf i Cn c ιt i m m t-' h-' t-' t-' t-' t-' -' t-' l-' t-' l-' -' I I I I I it- it- M M CO CO M M M M O O Cn -J CO CO CD CO —J CO ιt- C ιt- ιts. -- cn ιt- ιt- ιfs. ιt- C Cθ ιf=. cπ ιt» ιt- Cn ιf» CO M CO ιt- M CO M M M M O O M M O O O O O 73 U5 M Cn -J O M cn ιf-- C0 03 CO M Cn -O CD ιf » O cn M ιt^ M CD Cn CO O Cπ CO ιt s . ιt- M --J ιt* CD ι* Cn ∞ c --4 M CO C Cπ M M M M CO CO CD θ O ---J O Cn M OO --J ιf» M M cn M O CD CD M Cn CJl CO M CD ιt* CD CO Cn Cn Cn --J M CO CO --J ∞ co o co co cn cn cn --J ∞ --i M ∞ --i cn ιi-- cn M C M Ui θ M c ι co cn M θ cn ιi-. o θ M Cn cn cn o M ι* co c^ m to | _l f_l | _J | _l ,_. M M M M t- 1 O O O CZ) -' - 1 M M M M M M M M M M M M CO ooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooo ooooooooooooooooooooooo ooooooooooooo M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CD O M O CO CO Cn C O O M O CO IO CO CD CD CD CD O O O O M M M M CO M ιf- CO CO M M M M CO M M M CO CO ιts. C M M M M M O M M -J CO O M Cn w fc ^ o w n cfl W j i cn ij m θ B iji ffl Φ ^ o o o θ W w m M fr W φ ω ιn * fc μ ι» μ φ cή ffi μ φ ω o m -. ft θ ϋι n i t> u j CO O Ul ιti O O C ιt- cn M M M M C M M CJl ιC» M O O O CO Cπ -J ιt^ un M M M CO ιt- CO M cn --J --J CO M Cn CJl C ιI^ co cn cn --J co co cn cn co cτι cn --J cn cn cn co cn cn -J --- o cn cn cn co cn cn --J co 0ΩΩ300ΩΩ0 Ω Ω 3,Ω 0 ΩOΩΩ 33 OOΩ ΩOΩ 030 OΩ 3 ΩΩΩΩ 0OΩ 33 Ω 03 Ω Ω OΩ Ω 30 O0 Ω Ω 30 pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa μ3 H ι-3 H H ι-3 ι-3 H μ 3 H μ 3 μ3 3 H 3 H μ 3 3 >-3 3 >-- H μ 3 3 >-3 μ- i-3 H H-3 H H 3 (-3 H ι-3 3 H μ 3 ι^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 322222222222222222222222222232222222222222223322222222222 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ■-J --J -J --J -— ι -- --j --4 --J cn cn cn -n cn cn cn cn cn oN cπ uι cn cn cπ cn c^ C0 ~ cn Cn ιt C0 M M O CD C0 --J Cn Cπ ιt=. C0 M M O CD 03 -0 cn Cπ ιt- C0 M M O CD 00 --J c l Cπ ιt- 0 Ω Ω 3 3 0 Ω 0 Ω 0 Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω O Ω Ω 3 Ω O Ω Ω 2 3 Ω Ω Ω Ω O Ω Ω 3 Ω 0 Ω Ω 3 0 Ω Ω Ω Ω Ω Ω Ω pa CO CO O Ω 03 pa CO CO O Ω tO pa σ α Ω to pa 03 pa rsi CO O Ω 03 M M M M M M > to pa EC N M CO O O Ω t M M EC EC EC EC Ω Ώ Ώ Ώ Ω Ω Ώ Ω Ω Ω Ω Ω Ώ Ω Ώ Ώ Ω Ώ tr> tr 1 tr* f t→ f tr 1 fi pa pa pa pa pa fca f t 1 - i M f t→ tr 1 tr 1 pa pa pa pa pa ι-3 μ 3 ι^ H3 i-3 μ3 >-3 ι-3 H H M H f tr 1 tr 1 tr 1 Ir 1 tr 1 tr 1 rr 1 tr 1 tr 1 t→ tr 1 tr 1 tr 1 t 1 l→ Ir 1 to to o to to to to td Ir" i→ E" 1 tr 1 Ir 1 K, μ <, (-<, K - | t 1 t- , fc-' t- , μ ; κ! t- μ< X cn co ω co 333333 a 33 G G G G σ G a σ a a a c a a a G pa pa pa pa pa cn CO CO CO CO O to to CO pa a a p pa |D pd iD ?3 pd !D pd pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa CO CO CO CO it- cn cn CO CO CO - CO cn '--- --J i N μ fc φ O ϋi m ^ o --J CO cn C M ^ M M M M M M M M M M M cn cn cn O M M M Co M CO if* Φ cn uj μ M U o u o i U io o ω ife W -J ift ∞ co iΛ -i ui U j o J -J iJ M M M M M M M M M M M cn cπ ιt- cn cn cn ιt* ιt- co co M J o μ w μ *. o ω θ ω i uι co i o <) μ M ϋi t-> i-^ l-^ ooooooooooo ooo oooooooo oooo ooooooooooooooooooooooooooooooooo M M M M M M M M M M M M M CO CO M M M M M M M M M M M M M M M M M M M M CO M M M M M M M M M M M M M CO CO CO CO M M M M uι cn cπ cπ ra - j ∞ --J --J cπ cπ cτι --J M θ ∞ cn -J cΩ θ cθ !t M ω M -J co co ∞ -^ -j -~j -J Cn co M Co i ιt crN Cθ oo θ3 CD Cn cn cπ cD Cπ M Cπ o -J ιt- M CD ιts- o Cn -j --j cn cn — J M cn -J M M co cn cπ o CO M it- M cn it- o co co M M O — ι ∞ co ιt- M Cjι θ M on cn co --j cn M ιi^ co cn o cn co cn co oo M Cθ ιC- cπ cD M ιt- o θ M co cn o -J --J ∞ u-) θ^ u co cn oN -J ∞ co cn cn cn co cn cn -o cn cn cn cn ∞ cn c^ 0 Ω Ω a 3 0 Ω Ω Ω 0 Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω 3 Ω O Ω Ω 3 a Ω Ω Ω Ω 0 Ω Ω a Ω O Ω Ω 3 0 Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa H3 ι-3 ι^ !-3 H μ3 H H μ 3 H t-3 H μ 3 μ 3 ι-3 H 3 H >-3 μ3 μ H H ι-3 H ^ H ι- 3 H H ι^ μ 3 μ 3 H3 ι-3 μ 3 H OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOQOOOO 222222222222222222222222222222222222222222222222222232222 co ω co co co co ω co ω co co co co co co co co co co co co co co co co co co co co co co co co ω CO C C CO CO CO M M M M M M M M M M M M M M M M M M M M O O O O O O O O O O CD CD CD CD CD CD CD CD CD CD CO OO CX OO CO CO CO CO OO CO -O Cn ιI^ C M M O CD CO -J cn Cn ιf- CO M M O CO CO --J cn Cn ιl-. Cθ M M O CD ∞ --l cn Cπ ιf- CO M M O CO CO -J cn Cπ ι^ Ω a Ω O Ω Ω 3 3 3 Ω 3 Ω Ω Ω O O Ω 3 Ω Ω Ω Ω O O Ω O Ω Ω Ω Ω ΩΩ Ω Ω Ω 3 Ω O Ω Ω 3 3 O Ω Ω O Ω Ω 3 3 Ω Ω 3 Ω Ω pa tύ pa EC EC lNi tO σ Ω tύ pa D Ω Ω tύ pa EC INi CO CO σ O Ω tύ a 03 O O Ω tύ pa CO CO D D Ω tti M M M M M M M M M M M M Ir" Ir* pa pa pa pa pa pa pa pa pa pa pa pa pa pa H H H H H H H H3 H H >-. ι-3 H 3 pa pa pa pa pa pa pa pa pa pa pa EC Eπ EC Ec EC EC to to t→ IH tr' tH pύ pa po po fd po ΪO po fO pύ tr' tr' t-' t-' l→ tr' t-' tr 1 K; K K μ μ K; ; M M O CO C CO CO CO CO CO H H H H H H G α pa pa pa pa pa. o Q Ω Ω Ω Ω Ω Ω Ω Ω Ω -O tO tO tO CO tO tO CO pO fO JD PS pd pd d <pϋ pύ p ■ o ■ fα p3 pa pa pa Z Z Z Z Z Z Z z ω ω ω ω tn ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa M M M M M M M O o o o o o o o o o o co cD CD CD Co cD CD CD Co co co co co co co co co ∞ co oo -j -~j —j --j -j on cn ø^ cn cn cn cn cn cπ cπ cn cπ cπ cn M M M M M M M M CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO CO CO M M CO CO CO M CO M CO CO CO C0 C0 M M C0 CJ ιI-. C0 O C0 CD CD C0 --J αι Ul cn ---l C0 CD CD C0 Cn --J --I --J C0 C0 Cn C0 Cn C0 C^ c CO Cn -O Cn M CO OO M CO O J OD M ∞ --J -J O -J CD Cn Cn OO OO Cn CD --J CD M M M M M -J CD --l -- ] CD CD ιt> ιf- CO M M M M CD VD CD CD Cn cn cn --J - l '--J -J co ιt- cn cn on cn -J -J co co co co θ ιC M M M M C M M M O M M M Cn Cn -J — J co co m σN θ --J cπ co ιt- cn o cD Cθ co --j M M Co cn σN M M M Ui M θ co co ω co cπ cn cn -J -J co o o cπ cn co o ιt- CO 0 -^ --J Cn C M M M Cπ C C M CD M M O Cπ M Cπ cn θ ιf- M M CO Cn -J M ιI^ M O CD ιt- CD O CO C O O O O --J CD Cn Cπ CO cn C C^ -J OO Cπ CO Cn M M ∞ CD θ --J M CO Cn θ Cn Cπ M CO on CD CO C M M on ιt- 0 --l CO CD M CD Cθ ω ιI^ cn CD ιt- C^ I m m M M M M M M M CO M CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ■ — l σi Cfl CO --J -J --O M CD O O CO CO CO CD CO CO cn CO cn CO Cπ ---J CΛ Cn ιfc CD CD O O O O O M ιt- CJ M M CO ιt^ 73 M CD CO ιfe Cn C M CD CD Cn θ Cn M M ιf» M O --J C M c^ O M >t- O O ιt- CD M M Cn --J θO CO ιf- ω -J CD ω c M M CD CD Co co co cD ∞ cn θ ιi-- M ιi-- M co cn cn co cn cn o co cn --J ιt- co j^ θ ιt- on o --J cn M M Cn ^ Cσ -J OT --J M ω O OT !f^ M M -J M CO Cn M cn cθ ιt- ιi-. -J (jϋ CO CO ιt- Cπ CO O Cn M m to -> l- 1 - 1 I- 1 ^ I- 1 I-* -* - 1 t-* -> }-' }- x }-' l- i h- i t- -' t- i -' t-' - 1 ^ >-• b-' t-> I-* i-> t-^ i-* I- 1 H' t-' b^ CO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M cn cπ ιfc cn cπ cπ cn en cn cn ω M -- ] -o cn cn cn --J ∞ -- j --o - j c β --- j - j M c^ cπ oo M Co cπ ιii. cn cπ o cD ω M C7N Ci ιi-. M θ M Co cn co co cD cn co co cn M θ cD CD θ ιi^ ιfe ω O Cπ CD C cn θ ιt=. CO Cn Cn C cn M M M ON M >t> M Cn C M O M CO CO --J C l --I O M M ιfc M cn CO CO M C Cn c^ σi -J m ω m σi i i - m -J m oi cfi ω oN m -J oN cΛ ON n ω σi ' m -J o Λ ON m Ω 2 Ω 0 Ω Ω 3 a 3 Ω a Ω Ω Ω 0 Ω Ω a Ω Ω Ω Ω 0 Ω Ω a 0 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 Ω 0 Ω Ω 3 a 0 Ω Ω 0 Ω Ω 33 Ω Ω a Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p> pa pa pa pa r ,_ μ 3 >^ 3 3 H H H ^ ι-3 ι-3 μ 3 3 ι-3 H H ι^ H H ι- ^ H H H H H H β ι-3 H μ 3 ι-3 μ 3 H ι-3 ι^ μ 3 H H μ 3 ι-3 H H H H H rt H O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 222222222222222222222222222222222222222222222222222222222 ω co co o cj cj j co co w o φ CD j m ui oi Ω Ω O Ω Ω 3 O O Ω Ω O Ω Ω 3 Ω Ω Ω O Ω Ω 3 O O Ω Ω-O Ω Ω 3 C O O Ω Ω O Ω O Ω Ω Ω Ω O Ω Ω Ω Ω Ω Ω O Ω Ω tύ - ^> O O Ω tύ pa Ω Ω 03 pa O O Ω to pa Ω tύ pa Ω Ω l t-ort *W 33 _ O Ω a B H D Ω B pa D σ Ω to M M M M M M M M M M pa pa pa pa pa pa pa <; < <; < < , < pa pa pa pa pa pa Ω Ω Ω Ω Ω >-3 μ 3 ι^ μ 3 3 ι-3 Ω Ω Ω Ω Ω Ω Ω Ω Ω Ir , tr , r^ tr , rr' rr 1 tr' tr' tr' t→ tr' lr' ' c " o to to co " o " t " o " ω ■ - ■ c " pa ' pa t p p pa o o- ω ω co ω ω OT κ: EC Eα μC Eπ μC Eπ EC r , l→ H H H B t?l H TJ | τJ TJ i3 r 0 , fl l X) '3 t 1 t < lr ( t l tr t T3 T n3 n3 n3 f rJ n3 n3 EC EC C EC Ea EC p3 p3 pu ? ?3 p3 ? - a 2 a 3 3 3 2 a a G G G G a pa pa pa pa pa pa a„ pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ,pa pa pa pa pa pa |t*. lt- tt_ lt_ l t_ lt- lt- lt- lt- |f- lf* lt- lf lt- lt% lt- ιt- ιf^ ιfs. ιf- ιf- lf- ιf- ιf^ ιt- ιf- ιf- ιt- lf- ιt- ιt- ιf- t- ^ Φ ID Φ tD Φ CQ CO OO CD CD ω CO CO -J ^] —j -j --j -- --J c ι cn cn cn cn o-> m uN Cn c ι cn cn Cπ cn ιt- ιt- ιt- ιi^ ιt» ιi-. _^ M M CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO -J ∞ O CD CO ∞ --J --J -J --J cn --J CT> Cπ CO M M Cn ιf- CO M CO O CD CO O M O O CD CD CD O O M M O CO O M CΛ> CD CD CO ---J Cn ιt- ιf5. Cπ ιl-. M ιC. C ιP=. CO ιt- c w m i ti) uι μ o M n iι ) θ J M μ w ^ o ϋi o ^ N ) U fe (jι Φ * co iji φ uπ μ o o m J ^ co Φ θ μ u ffι θ φ fc (o w φ k iji ui u ϋi o CO co cn cD θθ ιi-. cn --j ιt* ιt- M θ -J ιt=. co co ιt- M M ιt- M cn uι co M CΛ C ιi-. co cn cn M M M ω CO Cn cn M cn cn oo <£> o co cD σ^ Cπ c^ --J Cn !_η ιt- CD -J CD --J ω cD --J co ∞ u) Cn ιf- I I I I I I I I I I I I I O O it. it- it* O O O O O o o M M M O M M M Cn co M M CO it- cD CO oo cn Cn cn cn co -j — j cn cn cn cπ cπ cπ co .t- ιt- ιt- ιt- cπ m 4 μ φ θ ι6 ω U μ ^ Ui i φ (Λ i_ -j μ o Φ θ i£i (jι o si ιo μ o M i ιs * fr Cti i ω μ co i i (> o o o o *, ω co ui φ (i) i- --i i co cn M oo o M M cn cn cn ιt» ιt- M cτi cn cn cn ιf* --J cD cn co co o M M cn ϋi M --J ω --i co ιt- M cn oo M ιf^ M -J o co cn M co ιt^ co o M α> o cπ co o (_π cn ιt- M Co crι C ι cn σN CD C co co o cn M M ιf- co M Cπ ιt^ m m M M M M M M CO M CO CO M M CO CO M M M CO CO CO CO CO CO CO CO CO Co 'c ω M M CO CO Co CO CO CO CO CO CO CO CO M CO CO CO "-J -4 --J c l --J 03 M C0 O M C0 C0 O O C0 C0 CD M O O M Ul Cn if- C0 M M C0 M C0 C0 O M O O M O M M M M M CD M O O C0 if- m cn ιts. co cD Co --j oD cn ∞ M M CD ιt- ιt- cn ---J θ M --J cn ιt- M M co co o ω w co M fΛ J Λ co o μ i vi cii uJ o ii ui μ ffi ui cfi o o f. 73 Cπ O CO CD < ) C O ιt* --J CO M CD CTι M CO cn ---- M M --J O C O C O M C ∞ --J --J M 0 03 Un cn M O M CD ιt- C^ c Cn C O C ιt* 0 -O M O M M O CD CD M CO CO CD M M ιf=. M Cn M CO Cn Cπ M CO ιI-. --I M cn --4 ιI^ CD O M cn M CD M --J -J m M M M M M M I- 1 b-> l- 1 >- ^ -' ^ l- i i-^ l-' - 1 t-' l- i - i [- i b-' i-> -^ i-' t-' i-' ' ^ t-> -' h-> i- 1 i- h-' l- A i-' t-' ' -' t- Λ i-' to O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M M M M CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M cs J ffl CO i i cn i ui u ^ o ω -i io o co ∞ a φ M φ ffl o μ M μ φ φ O O O a o o φ O Φ co co μ φ a j ^ i J m oi ή ^ Cή J m ιt- M O M ιt- --J CX ) CD O O --J M M ιfe CO M Cπ θ CO M --J ∞ --J cn M ∞ --J CO ι^ M M Cn cD O --J M U3 C^ M Cn cn CO C l ιt*. --4 --J M M U1 0 Cn θN M CO CO --J C^ CO on Cn on M M --J --J O O O M CO M --J ιt- ι^ M cn cn oo en cn — J oo oa on cn co on un --J u^ cn cn co oN cn — ι co ∞ o^ cn co cn cn --J cn cn ∞ Ω Ω O O Ω 300 Ω Ω O O Ω 3 Ω Ω Ω O O Ω 3 0 00 Ω O Ω Ω 3 C Ω O O Ω 3 Ω O O O Ω Ω 230 0 Ω Ω O O Ω 2 Ω Ω O Ω O O pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ta pa pa pa pa pa pa pa pa pa pa pa pa pa pa H ι-3 H H 3 μ 3 H H3 H μ 3 >-3 H H 3 H H !-3 ι-3 !- μ3 H H H H H3 3 H3 H 3 ι-3 H μ 3 ι-3 H μ 3 H H μ3 i-3 H H i-3 3 ι-^ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOQO 222222222222222222222222222222222222223222222222222222222 ιt_ ,ι_, ,t_ ,t- ιi_, ιt- ιfe ιt- ι μ - ιt- ω c ω co ω co ω ω ω co co — ^ m ^ ^ u M μ o φ ω I (J l Ul fc u μ o ∞ l m ϋl l^ ω ^) μ o c ' n u^ * w w μ o ω ■J ci l Ul l^ lJ μ o φ co l ffl u^ ^ ω 3 O O Ω Ω Ω Ω Ω 3 O O Ω Ω Ω Ω 3 Ω Ω Ω O Ω Ω 3 Ω Ω Ω O O Ω Ω Ω Ω Ω O Ω Ω 3 Ω Ω ΩΩ O Ω Ω Ω O O OO Ω 2Ω Ω to to O Ω to ! α σ Ω to D Ω to pa O Ω td pa O O Ω to pa D O Ω tύ pa Ω Ω 03 pa O Ω M M M M M M M M M MM p Ω O Ω Ω Ω Ω Ω Ω Ω pa pa a a p ι-d π3 τ3 fD π3 m π3 π3 π3 π3 τ3 m π3 τ l→ l^ W t< tr , - → tr , - → tr < tr , --' , l^ M M M w ω M ω ω ø Ω G G G G G G G G G τ3 π3 π3 πd iτ3 π3 π3 D O O O O O O O O O O O O O O G G G α α G G G α α G σ α G G G ?3 pO pU pO ?3 pO pd tO tO pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p a, pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn w -J cn cn σι cn cn cn cn θΛ cn cπ cn cπ cn cπ cπ cn cn ιi-. j^ ιf- ιt* ιt- ιt- ιt- co ω CO co ∞ _o co co co co co co o co co co _o co c_. -o co co -J ιf _o _ ιt- cn cn cπ >t- ω c cn o oo co co o o co cn cn cn i t. cn -J Co CO Cπ M Cn -— l O O M it- O it- O- its- O CO ip. -J - .M_ C_O CO- C_1. .M C __J .M C _n. C —O Cn M C C O cn ιt* -J M CD Cπ M CO M CO CO M Co co cπ M -J O - Cn co -j o cn M si U Uι θ Φ (Λ t. ϋι -j w _ ϋι μ o o J -J ΦCD θO NM) φCO wM ιM (<_sn (CΛn iC_ -J O Cπ θ ιt-. C C I_n M M CD CJ (_π --J O CO M —l CO M O CO Cl it- M O — J it- OO Cn CO CO ifc. O CD CD CD CD M CD O CO Cπ cn CO M O CO U-. O ∞ O C0 ιt- C0 Cπ Cπ M 0N Cπ 00 O O ιt- M M (_0 M CD O ιt» -J -- 1 1 1 1 1 1 1 I 1 I I I I I I M -J cn cn cπ ic cJ Co co M M __> o o O o o o o M O o it- CO CO M O O O O CO if- CO M M m Φ θ Φ w ω ^ Φ N_ (iι ω iD M -j μ uι iΛ) Ui M co α) m co ω i- c» φ ^J -J <)3 oι tι) ω ιis ιi- oι uι <jι . ι. θ ιi- Cπ M O M M cn co co co cn O M O cn M cn _1 _J 03 fc co φ ^ m -] co fc μ ^) Ul J ^o o I l Ul α) ^) αl _- ll) J- ιι- _ ' ^l CIl -l Ul ■ J I o o o- o Φ *■ M J5. O O iI-. -J M CD if * M CD M 00 U. M C0 CO M O ∞ CO M ιt* cn cn M M --] Cn Cπ CX> cn CO O CO M (_O CD M Co ai M M CO ιt» -O M CO CD CD CO on <Λ) σi M CD σ. M Co M M Cπ iC O N if^ O M CD M Ui CD CD Cn CO I m m - > I- -* . I-* I- 1 M M M M M M M h-^ i-' i-' i-' l-' t-' l-' i-' l-' M M M M M M M M M M M M M M M M M M M M M M 00 M O M M CO - CO CO M M O M M O M CO 00 -J n cn a-. cn — J co co co cn — J co co CD C0 O O M ιI^ M C0 ιt* C0 M C0 ιf* ιf* Cn ιt- C0 ιf- Cn cπ -0 _n -. u N) W Φ θi ι_ φ μ ∞ (ji -i u -J ι- _ι _ι o o ω w φ (- M -j ω i μ J θ μ *> oj o ϋι i_ (j μ ω M _ι u ω φ j μ H M -J CO M 73 C0 Cn en Cn O 00 --J M -0 M O -J ιt- C0 _0 _0 -J _rι Cn o _0 -J M —J Cπ --l M M Cn O -J C0 M C0 O -3 O O C0 -- C0 ω c _0 M C0 cn O cn Cn C0 C0 --l C0 --J _π _n --J ιf * M CD C0 _0 --l C0 -J C0 _n M -3 C0 ιt^ C0 ιti Cπ M ∞ m M M M M M M M M \-> )-> I- 1 \-* t-> I-* -> -> ^ l-^ i- i t-' t- i - i - i ^ M M M M M M to O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO C M M M M M M O M M M M CO O O O CO CD CD CO O CO CD CD O CO CO CO CO OO — J — 1 — J ON — J — J cn cn CO CO CD CO -— I — 1 O. ON -1 CJI C . II- 0. _1 -J -J _. CO M ifc CO M Cπ CO M CD CD M C M CO -J -J Cπ Cl M it- iti Cn M cn CO O M C M M cn M CO cn C if- m M Cn O C^ - j co co cn cn cn co cn cn - - co co cn cn co cn cn — J cn cn cn co cn cn — i _n _n c^ co cn cn --J cn cn _n -n co _n _n — J cn cn cn cn co cn cn --J cn co cn oo cn cn — J cn cn a 0 0 Ω Ω Ω 0 Ω Ω 3 0 0 Ω Ω 0 Ω Ω 3 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω 0 Ω Ω a Ω Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω a Ω 0 Ω 0 Ω Ω a Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa r _. _ _ ,. H H H 3 H H H H ^ ^ ι^ ^ μ 3 ι-3 H μ 3 H 3 H H H H H 3 3 3 H H H H H H μ3 μ 3 ι^ 3 f-3 H ^ (^ μ3 H H μ 3 ι-3 ι^ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 222222222322222222222222222222222222222222222322333222222 Cn C-i cn cn cπ cπ cπ ιi^ ιt* ιt- ιt- ιt- ιf- ιi^ ιt- ιf- ιt- ιf* _^ o o o o o o o co co CD co co co cD CD CD _3 ∞ _o co -θ co co _o co co _o -j --ι ---i --ι --ι -J -J --_ — ι -] _. _. σϊ cτ. cn cn _iN cn cn cn uι cπ cn cn cπ cπ cn cn _π cπ Cn Cn ιt- C0 M M O C0 C0 -J cn Cn ιt* C0 M M O CD 00 --! _n Cπ ι-- C0 M M O C0 ∞ -J cn Cn ιfe _0 M M O -3 ∞ Ω Ω Ω Ω O Ω Ω Ω Ω Ω 0 Ω Ω 3 0 Ω 0 Ω Ω Ω O Ω. Ω Ω Ω Ω 3 Ω Ω Ω O Ω Ω Ω Ω Ω Ω Ω Ω Ω O Ω Ω 333 Ω 3 Ω Ω Ω O O Ω D O Ω _3 pa Ω Ω 03 pa ω pa O O Ω- td O Ω 03 pa t- tO tO O O Ω tύ - pa EC EC IN1 C0 O Ω 03 pa M M M M M M M M M M f D π3 π3 π3 3 πJ 3 l D <J __ __ C _ CO C pa pa pa pa pa pa pa π_i fτ. 3 τ3 τ3 π3 π3 π3 π3 π3 τ3 π3 iD W π3 ^ EC EC EC EC Eα EC EC EC pa H3 ._ < < < pa pa pa pa _-_ t?o _o _o _o w rΛ _ _o ω _o ω _o ω ?α Eθ |D pd Eα !a pa EC Eσ EC to to to to do to to pj co t- 1 tr* tr* f tr 1 ^ ^ ^ ^ ^ ^ . . . . . . . . o ~ O ~ o ~ o ~ o ~ o ~ δ ~ π H is M H π H n w H π Ω " n ~ ~ ~ " ~ ~ ~ - pa pa pa pa pa p? pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa cn cn cn cn cn cn cn cn cn cn cn _n -n _n cn cn cn cn cn cn σι cn cn cn cn cn cn σN cn cπ cn cπ cn _n cπ cn c^ C0 C0 _0 _0 C0 C0 C0 C0 M M M M M M M M M M M M M O O O O O O O O _3 CD C0 CD C0 C0 C0 C0 C0 C0 ∞ _0 C0 _0 C0 C0 _0 C0 -- -J -J — J -J -J -J —J — J -J M M M M M M M M CO CO CO M M CO CO CO CO CO CO l CO CO M CO CjJ CO CO CO CO CO CO CO CO CO l-O CO CO CO CO CO CO CO CO ω CO C. -J -J -J -J -J — l CO O O O CO CO O M ιf. CO M M M M O CO O O O M M M cn cn >t. CO CO Cπ Cn -J _r) — 1- Cπ -J cn Cπ cπ cn cn -J M M M M M M O CO CO O c u^ cri O O Co en en o co M co co cn cD cn co co cπ co cπ cπ -— ! -J co _n c ιt. cπ co M Cθ ιf- -J M -J M M CO CO CO C CO CO --l ιI-. -O M _r. CO -J ιl_. M — I ιt- -J M CO ιt_ ιt- ιt- Cn M M Cn θ C0 M cπ --l M _n ιt- C0 M Cπ M ιf> — J cπ M Co co C _π cπ CD Cn M ιf- ιC" _r. M M CD CO M M CO M M M CO Cn CO ιt-. ιf- M O M _n θ M _n Cπ CO M _n _n -4 -J C0 M C0 it* M --l M _0 _n cn M C0 CXl cn O M O M C0 -0 C0 M _0 _0 _ri C0 CD O M _0 C0 -J CD C0 Cπ M ιt- Cn _r. CO M α. — ι co _n cn o co M M ιf. co I I 1 I I I I I I I I I Cn ιt» ιt. M O O M M Cn Cn _n _0 _ CO _O M O M M ιt> Cπ ιt5. _0 M M _0 ιf- C0 _π cn cn cn Cπ C0 C0 M M M M M O M M M if* if* CO M o o m O CO M — J O CO CO CO CO -— l M O M cn M —1 -J O CO ιI-. ιt. Cπ cn cn Cπ cn CO CD M Cn M Cn CO O O — J ιt- -J CD Cn --J O M CD — J it- Cπ O Cn cn it- CO it- M O M M co o co M _o ιt * cn cn o co co cn co cD ιt- co cD M _n cπ --i M cn -J -n θ ιf* --ι o co co _n -- ιt- ^ CO CO O M -J M Cπ α-. Cn θ M CO ιt- M M M ιt- M CO O M M cn M M -J M — J CO M Cn CO CD O cn M M M CO Cn O CO CD M CO O -— I CO CO M CO -J cn CO M O Cn Cn I m m M I — ' I — • I — » I — ■ I — • I — * I — > I — ' I — ' I — ' I — * 1 — > M M o M M M M Cπ M CO it- CO CO M M Co M M O Cn cn cn -J CD co co -J Cn cn cn co co -— i — J cn cn co cn co — j co cD co -— i — j cn c. ■ — _o M M cn oo ιt- -j _o co -j cπ M -J -θ M cD Cjn co cn cn co co cn cD M CD Co cπ co co M M M M M M i-" t-^ i- 1 ^ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M MMM M M MM M MM MM M M M M M MM M MMMMM MM M MM MM M M MM MMMM MMMMCO MM M MMMM M cn cn if^ it- it- cπ ife it- cπ cn cn it- it- cπ cn cn cn cπ cn c^ M cn cD -J M θ -J M cθ ιt* cn M cn _o o cπ M ιf 2 . cn oo ιt- _n _o _o co M M θ Co co cD M CD CD M M _π cπ -J Cπ ω ιf- C0 cn ιI-. C0 ιfc. O ιt- Cn _π —J M M ιt- -0 _n M Cπ _r 1 — I M M M M Cπ CO if- M CO CO Cn it* -— l ιl_. CO — I Cπ cn O CO M M O M O M M CO M M —I CD M Cπ M cn O -n cn cn cn co cn cn -J cn cn cn co cn -n — J eo cn co cn cn -J co co cn cn co cn cn — J cn cn en co cn cn — j _n _n _n σ. cn _n _n co cn cn -- -J --J cn — i cn cn cn co cn cn 0 Ω Ω Ω 0 Ω 0 3 Ω Ω Ω 0 Ω Ω 3 0 Ω 0 Ω Ω 3 0 0 Ω Ω 0 Ω Ω 2 Ω Ω Ω 0 Ω Ω a Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 3 3 Ω 3 Ω Ω Ω 0 Ω Ω pa pa pa' pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p ooooooooooooooooooooooooooooooooooooooooooooooooooooooooo 222222222222222222222222222222222322222222222222222222222 Cπ Cπ cπ cn Cn cπ Cπ Cn cn cn cn cn cπ Cn Cπ Cπ Cπ Cπ cπ cπ Cπ cn cπ cπ Cπ Cπ cπ Cπ c^ _n cn crι _n -n (_. cn _π (^ cπ -n cn _n _π ιi^ ιi-. ιt» ιfe ιt- ιt* ι^ CO M M O CD O_ -J cTι Cn ιf- CO M M O CO CX) --I cn Cn ιI-. (-O M M O CO CO -J Cn Cn ιt- CO M M O CO -0 -J c l Cπ ιl^ CO M O CO ∞ -I σi Cπ ιl-. CO M M O CD OO -J Ω 3 C0 Ω O O Ω 3 Ω Ω Ω Ω O O Ω 3 Ω Ω Ω O Ω Ω 3 Ω Ω Ω 0 Ω Ω 3 0 0 Ω Ω 0 Ω Ω 3 0 0 0 Ω Ω 0 0 Ω 3 Ω Ω Ω Ω Ω Ω Ω pa Ω 03 pa σ O Ω tύ pa Ω Ω tO pa O Ω tύ pa σ O Ω tύ pa P- CO O Ω tύ pa Ω Ω tύ pa 3 Ω INI CO to M M M M M M M M M M M - i3 n n n n n n t i t < , t i f -< t , t i <! <; <; <! n3 n3 i i D π3 π3 l D pa pa pa pa pa pa pa n θ Q ι CD C- Ω Ω < < < < EC EC M LD H M tO td tO M pa pa >3 ?) ?J ?i K3 I τ3 n3 EC EC EC pO pu tC EC EC EC EC EG G G G G G G G G t-* t- i g p ?) 3 ^ (B ffl - ] tn to (e (n !o t t < t t , t lr 1 lr l t t ^ )s ^ H3 K3 Ir*. > tr 1 " O O O O O O O l D f τ_ π3 π3 H. τ3 iD i3 α G G G G G G G G t- | t t- | lr 1 M to to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa -l -j -j -j —- jj —-jj —- Jj —- JJ ccnn cn cn cn en cn σN cn cn cn cn cn cn o^ cn cn cn -n cn cn cn cn o. cn cn cn c . cn cn c^ M M o o O O O O CD CD CO CO CD CO O D CO CO CO CO OO CO C I -— 1 —1 --J -J -— i — J cn cn cn cri cn cn cn cn c^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO ∞ O ιt=. M CD O M M ∞ OO CO O M M M CO -J C1 cn CO CO CJ1 0. -J CO CO -J cn - cn ι* CO ιt- U^ c CO — M CO Cn — J ιl-. CO CX ) Cn cD ιf- CO M O CD M θn CO M Cn cθ ιt- CO Cπ --] CO CO ∞ ω -J -J O M M CD ιI^ ∞ CD M M C CO —l CD Cn CO M Cn cn ιf* M C --] CO M Cn CO --1 0 0 ιt^ -J M M ιI^ CO O O M CO M M CD CO CO ιt* ( J 0 — J ON CO M CO CO — J Cn CO ιt. -J CO O cn M M CO CO cn M it- co cn co M Co M CO co M M itS ' Co o M Cn o o. M Co — J Ui co uι uι ∞ φ ω μ fc Φ W N) M ω cn w -» o uι oι l- ui φ Ui *. o. ^ μ i- -i φ _ι o. ι 1 I I I I I I I M I I I M I 1 1 1 1 I I I I I CO CO CO CD CD CO O -J CO CO O O O O M O CO M O O O M M o o cn cn cn m M ∞ M cπ cn cn co -J M -J M M c-. -- Cn CO M Cn Cn Cn cn iP. Cn M CO -.1 CO it- CO if- M co cn csN its. M if* M CD M CD CO M cn M O M — J 03 M C0 C0 cn U-. Cn ιt- Cn θ -J M — J M — J O M 01 M ιl-. ιfc. Cn ιt- C0 ιt- O Cn — l co M Co co on ci M cn cn cn co co if- co it- co cD cn m m M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO ∞ CD CO C» CO cn C0 ιt- ιt- CO Cπ Cn ιt- C0 ιt- Cn ιt* C0 C0 C0 M M M M M O O CO CD CO CD CD O O M it- M C0 C0 C0 M M C0 ifi. cn Cn Cn it- it. iI-. C0 73 oN θ ^ W Φ χ! w ω oι w ι_ o. ∞ ω ui φ (3i μ (_ m o. M fr M j o ι_ * θN ^ ω θ θ o. μ M * uι ∞ uι t!i -i oι co o — j —i -J M M M co cn cn cn o — l co co o -J en — - ] o φ θ (jι μ t. M m ιi) θ iB ω μ (iι ^ o. μ » uι μ ω ω i t. φ _ ) Ui (i) i t. M •f'- o o M on M it- cn -j -J cn cn o c M * o _ι i- m μ μ U m ϋπ φ i ι o ^ μ ω ϋi -i i o ϋi o -J o. A o. θ -) *!. - j μ N θ. ^ oo uι o κ "' -J CO M co M M iP' Cn oo cn σ. co cπ cn m M M M M M M M M M M M to h-~ ^ -^ ^ Y- i ^ -> \-> \-> i-÷ \-' \-> \- L \- i i- L M M M - 1 -^ -' ^ i-^ co O O O O O O O O O O O O O o o o o o o o o o o o o o o o o o o o o O O O O O O O O O O O O O O O O O O O O O O O O O O O o o o o o o o o o o o o o o o o o o o o o o o o o O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M I—' I— > I— ■ I—' t-> i- t-> - 1 t-' t-' l-' t-' t-' t-' t-' i-' t- 1 b- 1 -> t- 1 t-' M M M l-> H 1 1- - 1 O CD cn it- CO ■ — i cn cn — J Cn cn cπ it- on ϋ-i Cπ co co cD — - cτ> — J cn -o ∞ -D cn c — J — i cn cn cπ c^ cn M Cn cn M cn if» O M O M Co cD M C M co cn M co cn O it- co oo o — I Cπ M CO CO M Cn CD Cπ M OVO M C0 M M ιt- -J CO CO M o cn o co CO M M Cπ M Cn CO M ιt- M M CD CO CD ιl-. ιf>- M O -n M O ιt=. cn CD CO CO cn cn co — J CO CO it- cn CO Cn M M -J CO -— I CO CO M O O M —J cn o co -j — i M — J cn cn co cn cn -J cn cn σi cn co cn cn — - cn cn cn co cn cn -J cn u^ cn co cn cn -J co oo — i cn on os Ω 3 t0 Ω O O Ω 3 Ω Ω Ω Ω O O Ω 3 Ω Ω O O O Ω 3 Ω Ω Ω O O Ω 3 θ O O Ω O O Ω 3 O O O Ω Ω O Ω Ω 3 Ω Ω Ω O O Ω 3 Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ι- ι-3 !-a β μ 3 μ 3 >-3 H H ι- ι-3 μ 3 H3 ι-3 H 3 ι-3 ι-3 ι-3 >-3 μ 3 ι-3 ι-_ ι-3 μ 3 H μ 3 ι-3 >-3 ι^ H- H ι- H - OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO'OOOOOOOOOOO 222222222222222222232222222222222222222222222222222222222 cn cn cn cn cn cn cn o cn cn cn cn cn σ. cn <_n cn cn cn cn cn cn cπ cn c_π cn cπ cπ cπ c^ M M M M M H M M M O O O O O O O O O O CO -3 -3 -3 -3 -3 -B CO *-D -3 -O CD 03 CO OO CO CO CO ∞ o cD co -j cn cn it- co M M O cD Co — ] m uι fc ω N μ o Φ o j m cn ft (- w μ o . co , (s uι fe u ιo μ θ φ co . iJι uι *, ω ι. o Φ ii) j (s iJi * 3 Ω O Ω O Ω Ω 3 Ω Ω Ω Ω O O Ω 3 Ω Ω Ω Ω O O Ω 3 Ω O Ω Ω 3 C0 Ω O Ω Ω 3 3 3 Ω 3 Ω Ω Ω 0 Ω Ω 3 0 Ω 0 Ω Ω 3 Ω O Ω O Ω Ω Ω to pa o Ω Ω tfl p o Ω Ω tO p tύ p Q tO pa EC EC t. to O Ω td pa n B pa Ω Ω tύ M M M M M M M M M M pa μ3 t-3 l-3 t-3 ι-3 l-l l-3 M H M M M M M M H M M M M H H M pa pa pa pa pa O Ω Ω Ω Ω O pa pa pa pa pa pa pa pa pa co ι rj_ co co θ_ ι-_ μ 3 ι-3 μ3 μ3 p3 EC EC EC EC EC EC EC t tr , l , t lr l lr l t-- , t l-- , t tr 1 tr , _- 1 ? p3 ^ 3 ?d pd pd ?α ? ?3 pύ l?3 Pd t73 M tn M EC EC C E 0 ?) ?I J3 !S ^ ^ ^ . H H H t. H H t. H H H H t. M H H pa pa pa pa pa EC EC EC EC EC C Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω P3 3 p3 p3 p3 p3 p3 pύ p3 pO ϊD pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa te pa pa pa pa .p pa pa pa pa pa pa pa pa pa pa pa pa pa pa — J -— I — ] — J --J — J — 1 — J — J -— 1 — J — J —J — J — J — I — J — . — -J — J — J — J — ] — J —4 — ] — J — ] — J — 1 —J — I -J -0 — J — J —J — J -J -J — J — J — J — J ~ -J — -J — J —J ^ — 1 —J — J —J — J — 1 CD OO CO CO CO OD CO OD -J -J —1 -— 1 -d - -j —ι cn cn cn cn cn cn cn cn cn cn cn cn cn ιf- ιt- -^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M ._ M ._ M M M M M M M M M M M M M M M M M M M M M M M CO cn co cn it. — J cn cn cn o3 co co oo cπ cn cn cπ o M M M ιt. ιf- co co cπ ιf- ιt- c CoO cCoO θO MM MM MM MM O M M CO it. Cn cn — J o co co co cn cn co co -j — j co co co o co c cn — cn cπ cn M oo M — i M co M co co if- '— i it- cn co — i co en o cn O -J M Co cn Co o m *. Φ Φ o M C.π M. Cπ cn cD cn co Cn cn cn co iD CO M it- O O CD CO — l co — J ιt>- θ M θ M cD Co cD cn C cn cπ ιt» CD M cn co M ιt- cn cn θ ιt- M cn ιt- O O Cn Cπ M -J M M CCπn iiff-- cCnn con. ccoo M M cCoO cCoO iitt-- CCDD MM CCOO MM M cCoO cCoO cCnn oO cCOo MM CO Cπ Cθ σ. M ιf* M ιf» Cn c. CO CO CO ιfc. CD M O ιt- CD CD CO CO Cπ θ — 1 — I CD ON J- -J co co cπ co cn co — ) co ιt» M O Cθ cn ιt. ιt- cn M co cn co o co M co cn co I I I I I 1 1 1 1 1 1 I I I I M M M M M M M M M CO CO -J CO O O *> M M M O M M m cπ cn en -J -α M CO M --J M --l ιP. M co -J co j ιf--. cCoO cCoO oO oO oO ι it.- Mi. cn c_π. c-o- ccnn MM co co M M M -J O —i l co cn M cn M -J m m M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M cn co co co -j —j CO CD CO O O M M ιt- M C0 M M M C0 J-. -J Cn Cπ — Cn CO CO CO CD CD M O M M M M O O O M M M CO CO M M M -J CO CO M O M cn -J cπ cn co cn co co co co cn cn M cn co M M M cn cn -J co — J -— i cn — 73 o cπ cn M CD Cπ co cD Cn o o cn cD — i cπ cn — J cn CD CO co cn M co cn cπ cD co cD O cπ o cD M M Co cn cn cn co cπ cn co cn o. — l o — l it- co co M cn cπ co M -J iitt-- C CJO O O -J . M . it. — l . O _N. O if- CO OO CO OD M O π CO M OO l M M l-' CD it- CO c co cn cπ cn co cn M cn -J M ιfe ιf. co co cn M θ cD Co co -j ιi^ M ιf- ιt- -J co - --ι -j M -J u. Cn -J CD ιt- cn M Cπ -J C0 -. CD C0 C0 O M Cn CD CO cn CO O M M CO m M M M M M M M M M M M i- i l-^ t-' t-' i-^ i-' l-' i-' \-' l- i to co O O O O O O O O O O O O O O O O O O O OO O OO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M -' l-' - J l~' l-' t~' t- i t-' i- Λ i-' M M M M M jM M M M M M M M M M M CO CO CO CO M M M M M M M M M M M M M M M M M M —J en en en -J -J en o co co co cn — J cn cn co -4 — i — J -— I — I cn cn co CO CO CO CO M M O CO I— ' CO M M M M CD CO — l ιt- C0 Cπ Cπ ιt- C0 C-. ιl=. ιt- C0 O M M C0 M Cπ cπ cn M CO CO CO M ON Cπ — ] M CD CO CO M ιt=. O ιt* Cn CO --l ιt- -J -J Cn θ ιt- ιt- C- M - I M O ιf- C cn M -J Cn ιf- ιt- CD ιf. 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O Ω Ω a Ω O Ω Ω 3 C0 Ω O Ω Ω 3 3 3 Ω 3 Ω Ω Ω O Ω Ω 3 O Ω O Ω Ω 3 Ω O Ω O Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p- pa pa pa pa pa pa pa pa ^ ,, ,_, 3 H H H μ 3 H H H H H3 ^ μ 3 H H H ι-3 H H H H H H H H H H ι- 3 H H H μ3 H H μ 3 H H H H ι-3 3 H 3 ^ H 3 μ3 H ι- t- H ι-3 O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 222222222222222222222222222222222222222222222222223332222 cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cri cn cn cn oN cn cn oN cn cn cn aN cn oN cn cn cn cn cn c^ — J -J — j — J -J -J — j -— ι cn σN cn cn σ. cn cn cn cn α. cn cπ cn cπ cn cn cn cn -n cn ιt^ — J cn Cn it- CO M M O CO CO — J on Cn it- CO M M O CO CO — J cn cπ it- CO M M O CO CO — J cn Cπ it- CO M M O CD CO — J cn Cπ it- CO M M O CD CO — l cn Cπ ιt. C M M Ω O Ω Ω 3 3 2 Ω 3 Ω Ω Ω O Ω Ω O Ω O Ω Ω O O Ω Ω Ω O Ω Ω 3 Ω O Ω Ω O Ω Ω 3 Ω Ω Ω O Ω Ω 3 3 3 Ω 3 Ω Ω Ω O 03 pa EC EC tNi tO O Ω tύ pa Ω tύ pa CO tO D Ω tύ pa td pa pa σ Ω tύ pa EC EC INI tO O Ω tO n G M M M M M M pa pa pa pa pa pa pa pa pa pa pa pa „ > r p r a ω co co Co Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa C- Ω Ω Ω 1 D D 'D π3 π3 n3 D pa pa pa pa pO pd fd pd pO fd pα pO d Ea pα pύ ^ fd ^ iD tS W M - I —T t -?] ! "^ ^ !-- 1 ^ ^ tr 1 t" 1 tr* t* tr 1 tr 1 f f t* lr< Ir 1 " 1 tr* tr 1 po pO 3 pa p p3 p3 ■ p3 p -3 -ja p3 _?3 ^p0 t?_ύ ! -DJ P? Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω ?3 pύ 3 ?3 pα ?3 G G G G α G G σ σ pa pa pa pa pa μ ; κ; κj d O O O OO OΩΩ Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa p» pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ _} m co co m o3 o co o. α) α) co m ω o3 ω co co a) θ- t- Cθ tD θθ θ- oo.ra ∞ m -3 ω m α) (_ ω (_ o3 co oo -) (iι c- co ιi) co co o- i i -- - -j i j - -i ^ cn cn cn on cn cn cπ cπ cn cn cπ cn cπ cπ cn cπ ιt- ιt- ιt- ιt- ιt- ιt> co co co co ω M M M M M M M M M M M M M cn cn — i ce — l oo co -α -J cn cn cn -J CO CO M Cn it- cn CO CD CO CO CO cn O Cn ιt- ιt5. CO M ιf. cn o cn i- j μ u (. o cn cn ■ — l it- M I I I 1 I I I M M M M M M M I I I Cπ Cn -J M M M M M O O CO CO CD ffi U M N) i Ni μ ^ Φ -> t. μ m μ i o μ _> o ι. ijι ι. - i- I I M it- if- O O O M M CO it- CO it- Cn M M O O O O O O O O O O O O O O O O O O O O O O O O O O M M ιI-. O M co CO O cn co cn cn -J — j -J cn — i cn cn cn co cn cn -J co cn co cn cn — J ∞ co cn cn cn co cn cn — J cn co cn cn — J co cn cn -J cn cn cn co cn cn — J — J — J on — J cn cn cn co cn cn Ω 0 Ω Ω 333 Ω 3 Ω Ω Ω 0 Ω Ω 30 Ω 0 Ω Ω 300 Ω Ω Ω 0 Ω Ω 3 Ω 0 Ω Ω 30 Ω Ω 3 Ω Ω Ω 0 Ω Ω 333 Ω 3 Ω Ω Ω 0 Ω Ω to pa pa pa pa pa pa pa pa pa pa to to pa pa pa pa pa pa pa pa pa to pa to pa to to to pa pa pa pa pa pa pa pa pa pa to pa pa ,_ _. _. _ _. _ OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOQO 222222222222222222222222222222222222222222222222222222222 -J — J — J — I — 1 —J — I — . I -J -J -J -J -J -J -J -J — J -J -- —l -J — l -J — 1 — J ^ '-l ^ J ^ J ^ J -J ^ -i oN m -l -l -l ffl OI ON -I OI -l -l u-l ON -l ON -l ON m m ON CO CO CO CO CO M M M M M M M M M M M M M M. M M M M M M O O O O O O O O O O CO CD CO CD CD CD U3 -3 CO CD OO CO OO CO CO CO CO CO CO CO --- --1 J-. CO M M O CO CO — I cn Cπ it- CO M M O CD OO -J men (Cππ ιitb- lo M μ M n O i CDn c 0o0-—— 11 n CNn [Cππ -it-. lC_O wM μM nO ιCDn mCO --J mcn [-nn Jit-- !CιOi MM μM nO ιn _i - m (π -. l_ ι μ θ -i co Ω Ω O Ω Ω Ω Ω Ω Ω O Ω Ω 3 Ω Ω Ω Ω O Ω'Ω 3-0 O Ω Ω Ω O Ω Ω 3 Ω O Ω O Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω a o Ω Ω a a a Ω 3 Ω Ω Ω tύ pa D Ω Ω tO pa σ Ω Ω 03 pa to to D Ω 03 pa Ω Ω tύ pa CO CO O Ω 03 pa pa EC EC N to α Ώ M M M M M M M M M M M M M Ω Ω Ω Ω Ω Ω M M M M M M M M H M H M H M M M Ω Ω Ω Ω Ω Ω Ω Ω C1 . - . . 1-3 1-3 1-S Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa to to to pa Ir* IT* Ir 1 tr* tr* Ir* ' t* tr* tr* rr* tr* tr* t* t- , lr* t tr l t- 1 tr l t* ir* t-* t* tr l lr* tr* lr* tr* Ir* t* tr* EC EC EC EC EC EC EC t-* lr* t- | tr l t- < tr* tr" lr* t- , tr , t- , tr* tr l po po pα ?3 ?3 pϋ σ α σ a a σ to to to co to tO -O td to td to to co K H P1 G C G G G G G G G P3 po pO pύ po po po α α G G G G G G G J K Ω Ω Ω Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to pa pa pa to to pa to to pa pa pa p^ CD CO CO CO CD CΩ CO -3 -3 CD -3 CD CD CO CD CO CO CO CO CO CD CD -θ α- ∞ CO -0 ∞ 0_ M M M M M M M M M M M M M O O O O O O O O O CO CD CD CD CO CO CD CO OO ∞ CO CO uD CO CO CO ^ -J -J -J Cn cn cn cn cn cn CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO CO -O CO CO CO CO co co co co co co o M M M M Co co it- cn oo cn cn cn cn cn ui --i cn cn cn cri cn cn cn it * o M M CO -O M M M O M M M M M Co c M OO O — J M it- M M M O it- O CO M M M — J CD OO Cπ it- CO O M M C cn Cπ O Cπ CO O M CO O M CO it- CO CO -J -— I M O CD C0 cn it- -J CD CO Cn cn — J CO O CO CO CO it- co M co co -— l oo M ic Co co it. — . i — ι co cn M θ cn ιt- M cn c-. cD θ θ co ιt- o — J C M ιt* co -3 θo co co co co Co cn cn θ cπ cπ o cn M Cθ ιf. co σ. co M --o cn I I I I I I I I i- l-> t- > I I I I I I I I I I I I I I I I I M M M I I I I I I I I I I I I I I I I 1 I 1 I I I I I 1 I I I I I 1 I I I I I I I 1 I I I I o co ιt- -j cπ α. co αo — i cn M Cπ it- cπ cn cn cri -— 1 M M M CO CD co αD CD θD oo cD CD Co cxι oo cn θ M M M Co Cn cπ ι-- uι cn cn α . cπ -J co co co co oo m M -J O M 00 ιf- C0 M C0 C0 cn ιI-. O CD C0 M -0 O O ιt- ιl-. M M O ιt. CO M M Cπ M cn Cn ιt- O M cn θ CO M M M M Cn --J -- I cn O M CO M CO Cπ — J M M -J M cn C0 O Cn M C0 M Cn C0 C0 M C0 M --l C0 ιt=. O -J M — CD CO O — 1 0D CO ιf- Cπ Cn CO ιt- M CO CD CO cn M O . CO — J M Cn Cn M CD M CO — J Cn cn -J CD O Cn CD CD M co -J O OO M -J CO CD CO O M M -J O ιf. M CO Cn M Cn μ ι. μ φ j- ∞ ι_ μ -J -. μ ι) M cn J Φ oi Φ ϋi θ -i -) o σ; ιb μ t. θ j o μ ι^ w -- *. m m M M M M M M M M M M M M M M M M M M M M M M M M M M I I it- it- — j cn cn cπ cn ιf» cn cn cn cn cπ ιt- M M M M Cn ιi-. co M co co co co cD Cθ M o o CO CO CO M O O CD -J CD CO CO CD M O CO -J CO -J cn n o M Cπ CO ιt- CO ιt- M O M M O CO CO CO CO O CD M CD Cπ ιI-. CO CO M cn Cπ — I O M OD CO — J M M O CO M ιt- CO Cn cn on M M O M OO ιI-. 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G- Ω Ω Ω Ω Ω Ω Ω 3 H t-3 _ μ 3 Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω EC EC EC C C EC EC EC EC EC EC pd po ^ύ pα pd pα po pd po t→ ir* Ir* Ir* t* tr* t* Ir* pa pa pa pa pa pa pa EC EC EC EC EC EC tr* Ir* ir* Ir* Ir* H H Pl B B H B B B M R Ω Ω Ω Ω Ω Ω Ω fl Ω Ω Z Z 3 3 33 33 tr l lr* t-' lr* ir* tr < lr* pα pύ pa pa PO po pα G G σ a G pa pa pa pa to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa a pa pa pa pa pa pa CΩ CO CO CO CO CΩ CΩ CD CO CO CD CO CΩ CD CO CO CO CD CO CO CO CΩ CD CO CD -3 CD CO CO CO CO CO CO CD CO CO CO CD ω J -— I — — J — J -J — J — . I ^ ON ON m m -1 0N m Ul W -l -l UI CIl -1 ιfc ιI- ιI- ι-- ^ fc ι^ ιl- ιμ. ω -J CO CO Co ω CO CO — l ON ιt- ιt=. Cn ιt. C0 M - Cn cO if- CO M Cπ it- CD M —l O CO M Cn cn M M M M M it- M M CD CO CO —J M cn CO CO — J O 1 1 1 1 1 1 1 1 1 1 1 M M M M M M M M M M M O ιt. ιf-- ιf- Cπ M C0 C0 ιt- M M M M M M M M M M M M M CO O O CO O CO CO —1 C M CO M M -— l O — J Cn M M Cπ ιt- CO O O O M M M M M M M M O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M h-> M M M M M M M M M M M CO CO CO M M M M M M M M M M M M M M M M . - M i— M ,- M M M M M M M M M M M CO CO CO co -j co cn co cn cn co — J cn cn co . co cn cn co M co cn cn σN Cθ M Co o cD ιt- c__ co o o o co cD Cn cD co co -j - —ji ——j ——j --Jj - -j o o o o o o. co co co o. cn ic J-. OO J-. it- Cn CD CO CO CO --l cn M M CO CO CO i-- Cn CO it 5 . CO — J -— 1 M — I CO O ιI-. M ∞ M ιt* cn M cn M M M O — J — J it- M -J CO O O O O CO OO CO CO CD M CO Cπ N ) oi Φ o μ o u -i u o U -. oι ι * o ω u ω φ J A M s j o u μ -i m ϋi m ω ∞ t ^ ω Φ θ o o θ -i ϋ co M μ _ ijι J cn cn cn cn cn cn cn co cn cn -- 1 — J — cn — i cn cn cn co cn cn — J co cn cn cn co on cn — J cn cn o^ co cn cn -J ON Co cn co cn cn — J co oo cn cn cn oo o. cn — J co co cn ΩΩΩΩΩΩΩOOΩ333Ω3ΩΩΩ000330.00000Ω3ΩΩΩOOΩ300000Ω3000ΩΩOΩΩ'2000 pa pa pa pa pa pa pa pa pa pa pa pa pa pa to pa to pa pa pa pa pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa pa to H H >-3 ι-3 H H 3 ι-3 H H ι-3 >^ ι-3 H >-3 H H >^ ι-3 >-3 rt H ι-3 H μ3 μ 3 ι-3 H H ι^ !-_ μ 3 H μ 3 3 μ 3 t- H 3 3 H O O O O O O O O O O O O OO O O O O O O O O OO O O O O O O O O O O O O OO O OO O O O OO OO O O O O O O O O O 222222222222222222222333322222222222322222222222233222223 co oa ra co co oD CO cxi co co oo co α- ∞ co co oD CO co co co co co co co co ∞ J_. ιt_ J-. ιti μ-. J-. ιt* ιt* J_. C0 C0 l-0 C0 C0 C0 C0 C0 -0 CjJ M M M M M M M M M M M M M M M M M M O O O O O O O O O O CD CD CD C^ co — i cn cn it* co M M O Co co —i cn cn =. - M M O CD Co — J cn cπ *. co M M o co co -. i cn cn j^ co M M O co co — on cn ιf* co M M θ cD co --ι cn cn ιt. co M Ω 2 Ω Ω Ω 0 Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω O Ω Ω 3 3 Ω Ω Ω Ω O Ω Ω zon Ω 3 Ω Ω Ω O Ω Ω 30 ΩΩΩΩΩΩΩ0OΩ3 N W D Ω IB a td M O Ω Cd pa Ω Ω 03 CO O Ω Cd pa D Ω td M M M M to P W NHWDDOW to M M M pa pa pa pa pa pa θ Ω Ω Ω Ω Ω Ω Ω Ω <; < < < < < tr* lr* t- | lr* !r* lr* lr* lr* lr* Ω Ω ΩΩ - - . 1) π3 D po pύ pύ po po pd Ir* Ir* tr* tr* tr* tr* Ir* lr* lr* pa pa pa pa pa pa ' pa ' K K; HI.K tr* Ir* tr* Ir* po pύ pα pa PO pd po K; ; K; «; Ω Ω Ω Ώ Ω Ώ Ώ Ώ Ω G G G G G G G G G tr* tr* t-* E- | tr* F* co ω co co co c co ω co K t< O O o o o o O pύ pa po po pύ pa pa pd pύ pd po pa to pa pa pa pa pa pa ps pa pa to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to pa pa pa pa to pa pa pa l-> H 1 ^ h- 1 ^ -> ι-> ι-' i-> t-> t-^ t-' i-' -> )-> \-> ι-> ι-ι t-> -' -^ t-' l-> i-' >- i-> l-> l-' M M M M M M M M M M M oo oo oo oo oo oo o oo oo oo oo oo oo oo oo oo oo oo oo oo oo oo o o o o o o o o o o o o o o o o o o o σ o o o o O O O O O OO O O O O cn cn cn cn cn cn cn cn cn cn cπ cn cπ cπ cn cn cn cn ιt- ι!-. ιf- ιfe ιt- ιt- O O O O O O O O O O O O CO CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M c M O co oo — J cn cπ o. cn M co co co co cn c-i cn cπ co oD co -— i o o^ o. M M M ^ ιt- c cn oN θΛ cn ∞ CO — — - l i c uni M t^- — — J i M i — C — ini M ι^- — ■ — J i i μ t—- c uni O i . M i — — — i i __ — i c _n .i c ι_nιι c _o_ ..Mi j cni c -oJ c uni o i ' ιitμ*» M i — \Λ- cni c -o- ui ι wt-*. - ^ —J i O --* C -O- 1 M ι * CD * «■*. M r— C -Dj ιl--• Cni CO C uπi ιitμ** ιifμ** M i — ■ - -—JI M i — ■ — — J I its. Cn O CD M O CO Cn M M CO O CO CO Cθ M O MM OO CCDD CCOO MM MM MM CCDD --JJ iιtts*- ccnn CCOO OO cCnn OO CCO MM iιtt** COO oO M —- JJ iιtt*. CCO CCOO —-— I Cnn CCOO MM ——ll ccnn OO CCOO MM MM CCOO CCnn MM CCDD CCOO CO cn — J J-. — J O co cn o o j -. co M o co co M M CD -J -J co o cn co M — ι cπ M cπ cπ cD θ cn co M co M -J C ιt* cn co M cn co cn cn cn co o cn co — l o -J CO — J O CD M cn I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I M M M M M M M M M M M M M M M M M M M M M M M M M μ- » M M M M M M M M M M M M M M M M M M M M M M M M M cn — —i — cTi — i cπ ci cn o o co co -— i cπ cn v— Jj — J Cnπ c-πi ncNn (D ^ ^ φ -) φ θ3 -) - . -) H o μ o oι ^ tn φ αι ^ θ H uj μ * w j -> <)i -i -i ιb m co CO M Cπ ιfc. O O CD CO CO cn CO CD ιl-. _n ιf* Cπ Cn θ — I Cn ιf cn cn O CO M — J --J J=. it* CO CO CO ifc Cn — M O Cn -J Cn C0 Ji. M O C0 --J M C0 O M u. -J CD il-. M M CO CO — J if* C O C it* M CO cn C _. O M O M t-. M CO — J _ J^ O OO ιf^ on C LJ O Cn — l Cn M Cn M J-. M Cn CO M M Cn CD CO cn -J M cn CO CD Cn O CO CO M M M co M M cn co o cn M Cπ — i cn o co cn o -— ι ω Λ o W -i oi σι co o M m fc ft ιfc μ ^ m W ι- i - -i ui ι_ co ∞ j θ (> φ [ fc -i -i uj μ o m m M ■ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M o a co φ φ „ - ) φ θ fc M U fc ω w i- t- ^ - . ιn -i Λ uι oN -J ι- u w μ o α) [n φ φ o o o μ ιb ui -. i- l- i. u μ μ μ μ μ μ μ ι. M M 73 —I c Cn — J M Cπ M J-. CO — Cn cn — J O ιt- O O ιf* C0 C0 Cπ — J M Cπ Cπ — J ιf* Cn ιf* Cn _ C ιt* CD M co ιt* cn ιf* ιfa. M Cn o M cn cπ — j M Cn M M M O M cn CD -J CO J-. it* — l O CO M — J ιt* c_. M Cn co CD Cn CD M M C M — l ιt* O cn CO Cπ ι_* CO CO C CO Cπ -J CO -J co — -J M Cπ M co cD cn co cπ co cπ co M co cn cD M o co O OS J^ CD M C CO Cn CO CO C CO J-. M O CO O O — J CO Cn ιt* CD C0 C0 CD — J CO *. M M J=. Cn CD Cn M Cn -J M M cn cn CD CO M ιI-. CO O (jO --l ιt* O. CO M -J -J CO m to M M M M M M M M M M μ μ μ μ μ μ μ μ μ co M M M M M M M M O O O O O O O O O O O O'O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O CO CO CO M M M M M M M M M M M M M M M M M M M M M M CO CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M C0 cn M C0 C0 C0 O O O Cn -. Cπ ιf* M O O M O M M M J-. M M M O M O — J CΛ M C0 ιt* ιf* Cn Cπ ιt* J^ M M M ιf* M M M C0 C0 CD C0 C0 C0 C0 00 O O C0 00 M ON Cπ M -J CO On co i . — J CD M M M ιt* CO M cn ~!θ -J O J=. J-.- O M CO O O Cn M ιf=' CO C Cπ -— I C0 C i Cn J2. M -J CD CD Cn cn Cn cn cn O CD CO Cn Cn Cn cD cn cn M CD cn — i Cn co cn oo cn cn j ^ CO it* co cn M CD it* cn C-n M M cn o it* oo M C M Co M co cD if* c-i oo cn -— i -D cn — J cn cn cn co on on — i co co cn cn cn co cn cn — cn cn on co cn cn — —i cn cn cn cn co σN cn -— l oo cn cn — i cn cn cn co cn cn — i co cn cn cn cn cn cn cn co on cn — J Ω 3 Ω Ω Ω 0 O Ω 3 0 0 0 Ω Ω O O Ω 3 Ω O Ω 0 O Ω 3 3 Ω Ω 0 Ω 0 0 Ω 2 0 O 0 3 Ω Ω 0 0 Ω Ω 3 0 O Ω 0 Ω Ω Ω Ω 0 O Ω 3 to pa to pa pa pa H oHo3o3 HoHoo3oH μ o3 oooooooooooooo 22222222 22222222222333 CO -3 U3 CO CO CO 00 C0 CO OD C0 CO CO O0 C0 ∞ C0 C0 O0 C0 CO CO C0 C CX) O3 C0 O0 C0 ∞ CO CO o o o o o o co cD CD Co cD CD Co co cD co co co co co co co co co co co — J — J — — J — J — - J — — j -J cn cn σ. cn cn cn cn cn cn cn cπ cπ cπ cn cn cn cπ cπ cn cπ ιt. cπ ιt* co M M θ CD αD -j cn cπ ιt* ω M M θ CD CX) -J cn cn ιt5. co M M θ cD Cθ --J σN Cn ιt. co M M θ CD Cθ - O Ω Ω Ω O Ω Ω 3 Ω Ω Ω O Ω Ω 3 Ω O Ω O Ω Ω 3 O Ω Ω 3 Ω Ω Ω O Ω Ω 3 Ω 0 0 Ω 3 0 0 Ω 0 Ω 0 0 0 3 Ω Ω O Ω td O Ω tύ pa Ω Ω tύ pa Ω Ω tύ pa Ω Ω pa O Ω td pa tO to CO tO O Ω td pa O Ω Ω tD a a a M M M M M M M M Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa n Ω Ω Ω Ω Ω Ω Ω Ω H H H H H H H H pa pa tr*Ώlr*Ωtr'Ωlr*Ώir*Ώlr*Ωlr , Ώlr*<to.<pa<pa. pa<pa<pa<pa. - - - . - I. H Ω EC EC EC EC EC EC EC tr' t-' lr* lr* D τ3 π3 τ3 τ3 n3 π3 lr* lr* tr* lr* lr* lr < rr* lr* lr , tr , t- , lr* lr* lr* tr , tr* lr* tr* t→ G α α G G Q G C Ir* (r* rH iH l* rr* E-' pr- pd pO pd pd pd pd i-^ pd pd pO pO pd pO pa pa pa pa pa α G G G α G G G G H t t M tO t?0 _O tO Ω Ω pa pa pa pa pa pa pa to pa pa 'to to to to to to to Pa pa pa pa pa pa pa pa pa to pa pa pa to Pa to pa pa to to pa pa pa pa pa pa pa M M M M M M M M M M M M M M M M M M M M M M M M M M - i t- Λ h- i )-' t- i i-' )-* -' i-> t-' )^ l-' -' -' -> i-> t-* i-' }-> l- i l-> h t-> l-> l- 1 l-' t- i t- A ^ t-' l-- i Λ ^ l--' h-' -' ^ t-' l- i l-> i-- i t-> -> t-' t-* l-' i- i t-- 1 i-^ >^ i-> \-' * I M- 1 hM- 1 M^ M-' M M O O O O O O O O O OO COJ OO OO O-J OO OO COJ OO OO OO OO OO O ιf* ιt- ιt ιt* ιf_. ιf_ ιf* ιt- ω C C CO C CO CO M M M M M M M O O O O O O O CD CD CO CD CD CO α- CO OO CO CO CO CO CO — J — J —J —J — J —l -J — J M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO CO c Ji. Ji. ιt> CO O M M M O O M ιt* M M ( -J M Cn CO M M CO ( _0 -n CO M CO CO CO J^ CO J^ *. J-. CO Cn Cn cn -J — en — J -— I Cn Cπ cn cn Cπ M CO CO iI-. — J Cn j -. Cn M O CO M — J C0 O ιf* cn — M CO CO — O CD M M CO O — l it. cn o. 0 0 — I CD CXl CD Ji. ιt* Cπ o CD CD 0 03 CO CO M cn cn M M CO O M cn Cn cθ — J M C O CD CO if* M O CO M Co cπ co co co co M J5. cn cn co M M Co co — i co cn co it* — l O cD Co cn — . i J-- M M it* -n co co ji. cn cn o co cn --i CD Cn co cn cn co co cD — J M cn co M Co co co -j cn ∞ o co cn c^ θD ∞ M -J θ CD M ιt* co cn co co μ- » cD -n oo -J cn --J cn co cπ M -j --ι cπ cD Co cn o c^ 1 1 1 I I 1 I I I I I I I I I I I I I I I I I I I 1 I I I I I I I I l i i i i i i i M I I I I I I I I I I I M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M C CO ιf* ιf* ιt* Cπ o co cD -— i cn co co — j co co co co -J O. CP M C ιf* cn Cn --I u. Cn Cπ O O co co -— l cn cn on cπ co co M Cθ J=. cn Ji. ιt* cn cn m Cθ ιt» Ccnn CCπn -— aooD CcDo M it* O M -O M cn Cn cn --I CD CO it --J CX) CO O CD M C M CD CO -0 M.Cπ cn cn cπ co — l M CD ιt* θn ιf* --l M CO cn M CO CO cn θ -l — I ON -— I co O if* COO M M O - θ a> CO ID Cn CO O M O CD CO CO --l CD CO CXl CiN CO CO M Ji. Cn C cn CO CD Cn cD -J M ω W cn — J -J co oo -J -j.oo co cn o cn o — J CO M J-- o c i Co cn co on cn C-i o co cn cn co --i cD O CO M cn M Co o — i — J — — J on ιt* co ιt-. M Cn co Co co m m I I I I I I I I I it- it* cn cn -J — J cn cn cπ cn cπ cπ cπ it- CO O O O M M H-' M M O O O M CO CO M M M O O M J-- CO Ji. J-. CO M M CO ιt* — l J=. -J O. Cn Cn cn —! M M 73 cn CO M O Co -j -J co co cD Co co cn -J —l O J-' CO Cπ ιt* O O CO Ji. C M ιt* --l M cn -0 — J O ιt* J=. M -J M M — I Cπ if- CO M Cn c MM cCo0 MM CCo0 cCo0 c0nN oθ cCππ oθ cCDD CCnn c∞o cUππ ccnn ιιef*. JJ=^* MM O M C0 C0 Cn M cn M Cn --J _-. M C0 Cπ M O --l C0 0n c0 CD C^ μ -. ω ω _i ffi ϋι ( _ u o μ o oi co ω μ ui ιb M o ro oι μ -ι M μ ω ιb -i fc ∞ w ω μ .∞ oN Φ w m φ * g w μ ω (- o i- t. μ μ w M μ m to t-' l-' l-' t-' l-' l-' t-' J - J l-' l^ l-' t-' i-> }- l- i i- > l- i i-' l- 1 l-> l-> H' i-' l-> l- i >-> - i i-' -' h-> l-^ l- i t-> -> t- i l-' l-' i-^ t- 1 -' - i t-' co O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O ^-• t-' -' l-' i-' l-' h-' }-' M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO CO CO M M M M M M M M M M M M M CO CO — l cn cn cπ cn — J — J -— I -J -J i i μ (_ ω g o o μ μ μ w fc t fc uJ *> t ιb m iι) *. -i ιi- (i! g -i i -i -i ιt' Ui o) ~j g si o o Φ φ iD O CO ιt* CO CO CO O M — J M CO —1 C CO J=. — J *. 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CD O M O CO CD M CO — J CD M CO M ιt* CO CO J-. CO Cπ ι(-. -J M i— M ■— M i_. Cun. M r- CO -J C O M CD M -J O CO CD Cn — J CO -J Cn M M M C ιt. ιt* — J Cπ Cn M M O CD Cπ cn --l CD cn M M M M J-. in to o. α-. co co cD Cn M M M co co -ι cn co ιe. o on cn cn Co M cn M co M M θ Cθ M co cD CD θ -J — J CO CO CO M CO O M CO CO — J C0 ιt* CD -J ιt* O — J O O ιt* Cn M O C0 M C0 — J ιt* ιt* M O — J J:* CO O. M M Cn j-. CO M O (-J CO CO CD CO M Cn O CO CO _-. M Cπ M Cn M CO I I I I M M M M 1 I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I 1 I I I I I I I I I M i— ' M O CD CO CO — J ic cπ cn co —i cn cn cn — i — J σi ** ui Cn Cn M M Cn J2. CO if. CO — J cn cn C0 ιt* Cn ιl-. C0 M M C0 J=. C0 M M O M Cn CO CO J-. it* C COO CCDD C-D3 CCDD CC j nn -—JJ -—J J JJ--.. CCJn. CCOO -—J MM CCOO OO CCOO MM —— 1 I MM CO Cπ c l O O M O M CO -— I CD C J^ O M CO M Cn CO O M O CD OO — J M CO CD Cπ —J Cn CO Cπ ji. — on co cD cn m O. C. CD Cπ Cπ co M Cπ cn M O ιt* cn CO — J O Cn cn θ M O ιt M on α3 ιf* ON θ m M OO O O ιt* C CD Cπ C Cπ J-. Cπ _π CD M O C M O Cπ θ M C co CO Cπ cn Cn O M M Cn M — 1 — J CD CO M -J CD Cπ M Cπ M Cn CO ιt* M O — ! M M ιt* M Cn Cn -O M σN -J Cπ Cπ O J-. M CD -J CO M Cπ --J O J-. O M (_π Cπ --J ιI-. O CO I m M M M M M M M M M M M M M M M M M M M M M M M M ' M M M M M M M M M M M M M m co cD CD CD O Co cn — en — j co -— l cn o co co — J -— i cn cn cn M Co co M Co co co M co M co θ M M θ CD ιt* ιi-. Cπ cn -J co — O O O CO co — j co cn — i cπ — J — co cn co j-. ιt* co M cn co M M co M — i cn cn co o co co oo - i co o. — J cn cn co cσ o co cθ J=. cπ co co M co — j tf* o co M O J=> M C Cn CX> CO M J 5 * CO -J ifc. M CO cn O -J M O C O cn -J CO C CD --l CO M Cn cO -O Cn CD CO CO —J O — J Cπ cn -J Cn CO O CO CO — J O M CO Cn Cn cπ CD -J M Cn — 73 c -J O J-- CO CD M M M CO CD O M O M --l Cθ ' --I C-N Cn O CO M Cπ cn cn θ3 ιI^ M M C-. Cn cn CO M M (-n crι CD O W m t-' l- i \- i t- i t-' i-' h-' t- i \-^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M to co O O OOO O OOO OO OOO OOOO O OO O O O O O OOOOO OOO O O O O O O O OO O O O OO O O O O OOO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M co M co M M M M Co — J en co — J CO -— i -j co — J cn cn e^ cπ cn cπ M Cθ cD --ι --J --ι -J -J -J on on oN θN --i cn -J cn cn on cn cD — J —J cn cn cn en w co — j o cn — J cn M — i ιs ∞ u * ι θ (j ι o g -i oi -i ^ * ι oι μ * ∞ -i M (- H μ φ ft -i ω t ffl M w o ffl Φ θ ffl o -i l- -i Ni *. μ μ *, o ιt* OO CO O J=. CD CD CO — J cn cn CD M Cn O iti. — J J=. CD CO -J Cn co cn cn M C CO M CD M CO cn CO CD — M M Cπ cn cn ιt * M CD O M M ιt * — J — l co js. o Co co cn cn M M co on cn — J co cn cn — - i cn cn cn co on on — - i cn cn cn cn co cn cn — J cn cn cn oN O- on on — J on σ. cn cn co on cn -J co α- c. σ. α_. cn cn -— i co cn cn — i cn co on cn — i co O Ω Ω 2 O O Ω 2 Ω Ω Ω O Ω Ω a θ C0 Ω Ω O O Ω a Ω C0 Ω Ω O Ω Ω a Ω Ω Ω Ω O O Ω a θ O Ω Ω O Ω Ω 3 O Ω Ω a Ω O Ω Ω a θ pa to pa pa pa to pa pa pa pa pa pa pa to to to pa to pa pa pa pa to to pa pa to pa pa to to pa pa pa !-3 3 3 H μ3 ι-3 3 ι- 3 3 3 ι-3 ι-3 3 ι-3 3 3 >-3 ι^ ι-3 _ ι- H H3 ι-3 ι-3 ι^ 3 ι-3 rt ι-3 >-3 H μ 3 ι-3 OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 222222222222222222222222222222222222222222222222223222222 -' l-' l-' t- > i-> i- i i-' \-' i-' l-^ i-' l-> t- i i- l l- i l- i \-' l-* >-^ )-> O O O O O O O O O O O O O O O O O O O O CD CD CD . 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M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CD CD U- CD -3 CD -3 CD CO CXI CO O0 — J — J —J — J — I — 1 — l oN ON ON cn oN ON cn cn c^ H' i-> t- i l- i t-' -' i- Λ H' M M M M M M M M M M M M M M M - ω *. uj ιi* μ* ιi- ω ιf. CO CO J-. Cn J=. *. M CO CO M J-. Cn θN — J — J CO CO CD M M O it* Cn CO J-. CO CO CO CO j M O — J -J -J -J -J -J O O CD CD CO O CO CD c I Cπ CO Cπ — J CO CO CO O ιf* M ιt* M CO M M M J-. CO Cn CO CO O --J M CD CO CO -J ιt* CXI M M J-^ CO M M Cn M -J Cn M J-- M Cπ O M J=. 0 — J tt* M ιt* O M — J O Cπ oN CD CD — CO M ON CO CO M M — J ON M M O CO M CO M CO ιt* M J=. CD CO M O CO Ji. — J J-. —J M CO cn — J M O cn cn o o — ι cn en cn co M θ M co o ∞ oN cn co cn cn co ∞ co cπ M co cD cn o co M Cn co --J ιt. co M cπ (- M — j co -o co cn oo - j ji. 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O M M CO M w-M u t. -n> uι oι μ μ o CO CO CO O M CO CO M Cn CO Cn CO CO M M O M CD Co M Cπ cø cπ -j co — J M CO CO O C CO O CO -J O M CO ON Cπ cD Cπ M ιt-. M --J CO — J C0 cn M θN ιt* CO CO C0 73 CO J-. CO CO Cn CO -J O M CD J-. O ON -4 -J O Cn CD M M CO M ON M CO cπ (jθ cπ M cn ∞ o co (jθ co cn θ3 M cn cn cn cτι M -θ -o cπ o cD Ji. cD M -j --i ιt* o M c — J J=. O O O CD *. O M O Cπ C0 M O O *. _J il* CO -l ib -J CO -J _ ) -J Cn co cn cx cn cn M O C co M M CO CO J=. oN O M CO M cn O O cn Cn o CO M CD Cn m M M M M M M M M M M M M M M M M M M M M M M M M M to co OOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOO OOOOOOO OOOOOOO OO O OOO OO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M MM M M M M M M M M M M M M M M M M M M M M M M M M M M M MM M M M M M M M M M M M M M M M M Co oD co co co co co cD — J cn co cπ — J cn cπ cn cn oN Co O co oo co co -— i - j — - j -j co o co co co o co co -j co co co o M O M o o o o o M -J cn cn it* M M M CO it* — I ON CD C0 M J-. Cπ <_π C0 Cn C0 J i . — J M Cn CO O ON CD Cn -— 1 it* — -— l it* -— l J-. M Cn -J CD M O ∞ M J-. Cπ —) CD C0 Cn CD CD — I Cπ — J cn J* ON Cπ ji* CD μ μ *ι o ω θ M μ m o φ g _ ^ μ ui -i φ M ιb μ μ i_ -. oN θ ] i co ι. co uι J * μ -i φ fc - vj * M N - o o ιo m fc Φ θ -) φ co cn cri σi co cn cn — ι co cn cn --ι cn cn oN cn co cn cn -J co cn cn cn cn cn cn cn ∞ 00 Ω Ω 0 0 02 0 Ω Ω 3 Ω 0 Ω Ω 0 0 Ω 2 0 0 Ω 0 Ω Ω Ω Ω 0 0 Ω 3 Ω Ω 0 0 Ω Ω Ω 0 0 033 Ω Ω 3 Ω Ω 0 Ω Ω 30 0 Ω Ω pa pa pa pa pa pa pa pa to to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to to pa pa pa pa pa pa pa pa pa pa H3 3 ι-3 ι- μ 3 μ 3 !-3 >^ H !-3 i-3 H ι-3 H. H H H 3 μ 3 3 3 H H !-3 ι-3 3 ι-3 H '-3 3 H 3 H3 ^ ι-3 3 H !^ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 222222222222222222222222333333332222222222222222222222222 l-' -' h-' l-' l-' l-' l-' -' -' l-' l-' l-' h-' t- l-' t-' -' l-> l-^ t-' l- i - i -^ t- 1 ι-^ l-> )-' l-> l-> l-> h^ l-> l-> l-> t-> l-> t-' l- i l- > l- i l-> t-> M O OOO OO O OOO OOOO o. o o o o o o o o o oo oo oo o o o o o o o o o o o o o o o o o o o o o o o o o o o o oo oo — —i — j - j -— ι - j -J on cn cn cn cn cri cn c cnn c_n. cn cn cπ cn cπ cπ cjι cπ cn cn cπ ιt_. ji. i. ιt. j-. ιt. ιii. ji. ιt * j_. co co co co co co ω Cn Cπ Ji. CO M M O CD CO -J ON Cn ιt. C wM Mμ θO CφO CcOo -^— l conι oi Jb u M θ ω oi ϋi ^ u w μ o Φ ffi -J oN Ui *' U i- θ θ) - -i ijι *. u ι. μ o O Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω 3 Ω O Ω Ω 3 3 O Ω Ω O Ω Ω 3 Ω O Ω O Ω Ω 3 3 3 Ω 2 Ω Ω Ω O Ω Ω 3 Ω O Ω Ω 3 0 Ω 0 Ω Ω 3 0 pa CO tO O Ω tO pa tύ pa D O Ω td Ω Ω td pa EC EC N el O Ω td pa 03 pa Ω td pa CO M M M M > M M M M M pa Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pa pa pa pa pa pa pa pa to β i-a β μS μS μS pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa co o c co c co Ω lr* t H tr* t^ lr* tr* lr , lr* t tr , t lr* lr* tr* t -r 1 t „- 1 tr* tr , tr -O C/- to co to to co to EC EC EC EC EC EC p pO pO pO p0 pd pO p0 p0 p0 pd !-* jr* !r* lr^ lr* t?d tκl tO tO tO t- , pa G G σ σ G pa pa pa pa pa 3 3 3 a 3 3 3 3 pa pO pO pO pd pύ Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω pa pa pa pa pd pd pd pd pα pd G > pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to to M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M co co co co co co co co co co co co co co co co co co co co co co co co co co co co co co i-o ω co — j -j -j -j on cn cn cn cn cn cn cn cn cn cn cπ cn cn ιt * ιii. j-. -. ^ i. j-. j-. co co co (jθ co co ω CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M c g ω ω θ ffi φ θ Φ ∞ ω ω J ϋi -i σι -i oι o θ Φ J -- ∞ φ ω φ θD i o3 Φ θ -i «. t. -> t> K ) μ μ o o μ μ co o3 co . oN θ ω CO ■ — i co co co i. it* -— I it. ui ω -i (* - ι o o cn cD Co cn ιt. cπ cn co -J cn ιt*. 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Ω Ω 0 Ω Ω330Ω Ω 00ΩΩ 333 Ω a ΩΩΩ 0 Ω Ω 3Ω 0 Ω Ω to pa pa pa pa pa pa to to pa pa pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa pa to pa > pa pa to to pa pa pa pa pa pa pa β - - β β - - - - - . . . - - - - . - . - i. - - β . . - . β . - - „ i- - . - . - . - . „ . H - H . i- - - i- . ri . - ooooooo ooooooooo ooo oo ooooo ooooo ooo oo ooo ooooo ooooo ooooo ooo 3 2 2 2 2 2 2 2 2 2 2 2 22 2 2 22 2 2 2 2 2 2 2 2 2 2 2 22 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO CO 00 CO CO CO CO CO CO CO -J —1 -J —1 -J -J -J —1 -J —1 ON m ON ON ON ON ON ON m m Cn Cn cn in Cn Cπ Cn n Cπ Cπ J=. it. it. it * it* Ji. if. it* if* it* ω CO CO CO (0 O O O CO -J ON Cn it* CO M M O CO CO -1 ON n it* CO M M O CD CO -J ON cn Ji. CO M M O CD CO -J cn cπ Ji. CO M M o CD CO -J ON Cπ Ji. CO M M o CD CO -J ON cπ Ji. O ω co co Ω Ω Ω Ω Co cΛ ω co θj ω ir< lr* tr , tr* lr* t- , lr* tr* Ω Ω Ω Ω ffi EC EC EC EC EC EC EC EC ffi M H M Ir* t→ rr* lr* tD M H M M M M H - M W I?d td M ρo pd pd po ρa pϋ po ρα pd α α σ σ c G σ σ ω ω ω ω ω ω ω ω ω ω ω ω ω w ω ' 'p pa pa pa pa pa pa pa pa pa pa to to pa to pa pa pa pa p3 pa pa pa to to pa pa pa pa pa pa pa pa μ μ μ μ μ μ μ μ μ μ μ μ μ'μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ .cπ cn cπ cπ Cπ cπ cn cn cπ uι Cπ C-. C- tJ Cπ C-. cn C-. C-π CJι c^ " it* ιt * ιt- ιt * Ji. ιf * ιt ιt ιf* ιf * Ji* ιt* ιt ιP * ιf* J-. Ji* J^ co co co M M M M M M M M M M θ o o o o o o o cD CD CD CD Co oo co co co oo co co co co - -j —1 — i —i -j — J — —i cn _n cn _n _n cn cn cn cn cn cn cn cn M M μ μ μ μ μ μ μ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CD CD CD CD CD O O CO CO O M Cπ CO CO M M M M O M M CO O O CD CD CO CN Ji. Ji. Cπ Cπ M .O O CO — J n Cn Cn Cn CD M M C0 C0 C0 Ji. 0N Cn Cn J-. c — J O CO M CO CN M O ιt. M J-. CD ON CX> M --1 0 M M CO C cn cn M Ji. M M O O CO CD Cπ Cπ CD CO CO Cπ cn M M CXl CO ∞ CO cn cπ M —i M ι3n θ Co --j ιii. co _ ιt* - cn α- CD ιi-- co o cπ co — i -i . σi -i Ui (- o o W Φ JN θ -i μ ι_ oN μ -J α) μ *. ω t. ι_ ι_ *i -i o l_ *ι μ o μ ιt> CO M -J 0N Cn M M CD ιt* O Cn -. C-N C0 -π Cn M Cn C0 M C0 Cn C0 M --1 0D _n ιfe M C0 -J O -J C0 C0 Cπ C0 Ji. ^ I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I 1 I I I I I I I I I I I I I I M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O M M CO M M CO CO Cπ M CO Cπ Cπ Ji.. Cn Cn --l cn cn --J CO CO CD O O O CD O CD CD CD CD O O CO _O M CO M M M M M OD O CD CO O M O CD CO CO CO Ji. cn m O O CO it- Cπ cn -. I CO O CD CO O M -J — J ιt* C0 C0 CO CO — J M Cn CO M O CO Cπ O Cn O CO CO M crv -O cn CD M M CO CD M O ιt* M M CO O -0 — I (JI *■ * ι o μ ft Co co co — J θ ιt * _o — J en — i cπ cn -J Co cn M co o M cn co cD Cn — J en — J CO CO CΠ M Ji. M CO J-. ON CO M M Ji. CO cn ιt* -J CD — J Cπ — J OO M CO —J CO CO ιIi. O ON C CO M co cn o o oo it _o --j -J O M cn co cn ji. _o -j M Ji. o co o Co i. cn — J ιt* co — J M Cπ co co -J M -J CO co cπ co CO Cπ — J Co ji. cπ _n _n σ N θ Co cπ J-> co Cπ I m m M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M OS -J CO CO CD O M it. -O Co M CO ii-. co —. l —j cn ιfi. J-. -n --] — J — l ON cn — i cn —i cn — J CO — j -J cπ ιt* ιf * co co _o cn _π co _o cD co co o M ιf* _o M M ιf* M M M Cn C0 Cn _θ M ιt* M M Cn M Cπ -O cn CO -J _O J ιti*. Ml\- CCO_ __Oo Cuπi C-DJ __0o Cun c 73 ι cDo M)— ' JI-.. CUO-J CCDO CCDD MI— ' — Cn O cn if* — l ON CO M M M -— ] M Cθ CΩ _n CO Ji» _ Ji. — l Cπ M M CO CD c Co cπ — M Co Cπ cπ cθ ιii. Cθ Cπ M M M — I M ιJbi- bJi- ccoo c_πi φcD C-ni —*j J ιιt* CD mON ιJti-. MM ιfe -i M μ -i m _ι o -J -i m o - g -i fc oN -J -) -j μ fc -i i- W (- μ o M cn -J co cn co M M cn M cn cn co --ι — J M J *i.. --.ι ucπi fcιt* ιι(t.* -Nj ιfci-* co J*i.. oθ ιM. cD (- M (!i o w o (> o μ -i θ U -) θ -i Φ -i -i * ι μ ι i _) ι_ -i m to - 1 h- 1 - 1 I-* I- 1 * M M M M M M !-• H> l-> >-> μ_ι μ_ μ_, μ_ 1- - > ÷ 1-* >^ 1- - 1 -' -' -> H' ^ M M M M M co O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O CD -3 M O CD O CO Cn M M CO CO M CO CO O M M M M M .M CO M CO _O M M M M O M M M -J _n Cπ CO M M M M O CO ιt* J-. CO M M O M O Cn -J Cn -J cn cn CO O M CD CO CO CO Cn CO —J M CO O CO — J it* M M _n Cn _ M M -— l M CO cn CO M M _ M _n θ _n en -J M M M -J CO ιl-. CD M M Ji. ιI-. ON M _0 _n O -J O M co _o M CO ii-. O M M co cn cn cn it* — i cn -J — J - ; J cn σ cD co —J CD M Ji. M co cn co co _o — i _-i M co o co cn co o Ji. cn cn co i. o M cn co oN Cn co j-. co cD oN cn — J co cn cn — J co cn co cn cn -— l en cn cn cn co cn cn —i co oN cn — ι -J _ι o -J θN -i t_ m n -J ^ θN _ o -) -i -i j m m oN i-i m -3 σι o -j -\ -i (jι σι Ω Ω 30 0 Ω 30 Ω 0 Ω Ω a Ω Ω Ω Ω 0 Ω Ω 3 0 Ω Ω 3 a Ω Ω 3 Ω Ω 0 Ω Ω 3 3 Ω Ω Ω Ω 0 Ω Ω 3 00 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω to to pa pa pa to pa pa pa pa pa to pa pa pa pa pa pa to pa pa pa pa pa to pa pa pa pa pa to pa to ,_- ^ ^ ^- ^ H H H H ι^ ι^ >- H ι^ ι-3 H μ 3 H ι- ι-_ μ 3 μ 3 ι- 3 H rt ι- μ 3 μ3 μ 3 3 ι^ ι^ H 3 rt H ι-3 3 3 μ 3 H H ι-3 ι-3 H o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 2 2 2 2 2 2 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M W M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M j _. J_. ιl_. _. ιt* j_. J_. _. _0 C0 _O _O C C0 C0 CO (-0 CO M M M M M M M M M M M M M M M M M M M M O O O O O O O O O O CO CO CO CD CD CD CD CD CD -J _n Cn _. C0 M M O CD C0 -J cn Cπ ιt. C0 M M O CD C0 — l cn Cπ ιfc _O M M O CD CO -J cn Cn ιt* CO M M O CD CO -J _n Cn _. _O M M O CD CO --J cn _π ιt- _O M M ΩΩ32ΩΩΩΩOΩΩaθO Ω Ω Ω O O Ω 3 Ω Ω Ω Ω O O Ω 3 3 3 Ω 2 Ω Ω Ω O O Ω 3 Ω Ω Ω O Ω Ω 3 Ω Ω Ω O Ω Ω 3_ O_ Ω ._ O a i tO O Ω td pa tO tO σ r-i Ω o t md pa O σ Ω tα pa EC EC N tO σ Ω Cd pa Ω Ω td pa Q Ω td pa cn 03 M M M M M M M < < lr* _ H t→ tr* tr* tr* _-* lτ* _H Ω Ω Ω Ω Ω Ω Ω Ω - .Ω Ir* __^ __ __-< l_r* l_r* l_r* __-* ^ pa to pa pa pa pa pa pa pa < <; <; < <| < < Ja J * t _ H t* -0 -0 1?- td tO - td . pd pd pd pd pa pa td to P S a K K t^ f f t 1 tr* tr lr* lr* ω co o_ - ι _o _- Co co G G G G G G G σ G G G G G G G G G Ω Ω Ω Ω Ω Ω -? ΩS 2Ω-? 5Ω? Ω--? Ω-3 tr fc r*| Plr ; l l Plr :: ! l Pir ; *! Plr : *! Ptr ; *! ?tr : !' Pir : *'. fe ^ _? < < CO CO CO tr* tr* po po po pa pa pa to pa pa pa pa pa pa pa to pa to to pa pa pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa pa pa pa to pa pa pa p^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M cn _n cn cn cn cn cn cπ cπ cπ cπ cπ cπ cπ cn cn cπ cπ cπ Cπ " uι uι _ι uι ui -i Ijι uι u Uι ui -i -i Ui -i -i _i -i -i Lιι _ι IΛ Uι _ι Ui -i -i Ui -i Cn iJi Uι _ι cιι uι Uι Uι o o o cD Co co CD Co cD CD Co cD CO co co co co co co co co -J — J — J — J — — J — J cn cn cn cn cn cn cn cn cn αN cn cπ cπ cπ cπ cπ cn cπ ιt* ιt* j-. -. ιt* -. ιt* co co co i- 1 - 1 -' M μ μ μ μ μ μμμ μ μ μμμ μμ M M M M M M M M cn cn it* — J co co o Ji. CO M M M M CO M M M CO ιt* CO M M M O O OO O CO OO CO -J CO CD CD CO CO CO CD O CD CO CO M M O -J CD O -J -J O CO c J-- M M M Cπ C — I Cπ M OO -J M cn cn --J Cn M --J CO M Cπ Cπ M M --I M cn CO C3N Cπ C-J M Cπ θ CD C -J C^ CO O M M α_ CD 03 M ιt* 0N M -0 -0 C0 J i . M 0D C0 C0 M -J M O _0 C0 O <_0 M M Cn cn σN -- J CD ιf* O J i . Ji. CO Ji. O ON — J ON ON CO C Cn M ιf* M CO CO O Ji. ιt* M M M — M CO ON CD Cπ CO O O iC O M M — J — CO ON CO M M M — J O CO Cπ M Cn oN O CD Cn cn CD O CD — J CO CO CD M J=. O M CD ιt* -J Cπ θN CO ON Cn θN O M O M CO ( I I I I I I M I I I I I I I I I I I I I I I I I M I I I I 1 I I M I it. Cn -. O0 — J — ON ON C-N Cπ Cπ ji. M O O O M CO CO M M 0 0 0 0 0 M O CO CD — J CN Cn ιfi. M M CO ιt* ιt* M ιt* ιt* ιt* Cπ ON O CO CD --J -J CO cθ CD O CD m M O CO J-. CO CO — ] ιt* CD —l Cπ M M Cπ O CD M — J ιt* O Cπ cn ιt* ιt» O Cn M M — ! O O C0 ιt _π O cn M -J _0 C0 CP C0 _π -J _0 Cn _. J-. Cπ C0 -J C0 C0 -π cn C0 O ON M J-. M CD Ji. Cn ON CD ON M _O O il-. CO M — J Ji. CD Cn Ji. M -— ! Cn θ Ji» CXl M ιt* ON O Cπ cθ M C l M ON ON Ji* ON CD M ON M M Cn Ji. CO M Ji. Cπ J-. Ji. CO CD CO co Cπ ιfi. —J M OO CD Cπ CO Cn cθ - Cπ ιt* Cπ O --i Cπ O CO O Ji. M CD -J CO O CXI CO M M M Cπ cD O M C^ m I I I I I I I . I I I I I. 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M M M CD Cn Cn M Cn CD O ON _O CO CO _-i _0 0 --I _π cπ _n CO CO --I O _π θ ω c _n -J co o cD _o co ιt* cn -J θ — i U -i θ -i ^ lθ m o o θ -i ω i- U M Φ Φ -i -i μ ω uι U ω o cn ∞ φ -. ιb i. μ μ J o oo -i -i o ι m ^ \-^ h-> i-> b-' t-' i- 1 t- 1 ^ -> \-' t-' l-' ^ Λ -' l-' ]- i ^ -^ -^ i- i ^ I-' t-> h- 1 ^ CO 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 M M M CO CO M M M M M M M CO CO CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O CO CO cn Cπ Cn ιf i . μ -* cn cn ιf i . M CX ) J i . Cπ Cπ C CO M CO _P M M CD α3 M M M M M O M CO CO O C0 03 — J CO CO CO CO —I CD CO CO -J CO CO CD M O O. M M CD ON CD CO CO O J=* O CD CO M O O -- I M ON Cn — ] φ U1 0 U ιb _l -1 0N OI O Ul * J M Ji. CO M Cn CO M C-. -O O CO _O CO M CD -O _O O M CO cb _O J-. M CO — i M M -J cn o co cn M co cπ — cn co j i- o — _o M _π cD -J o oN _π o cD M θ _o _o M M J-. _n θ M M — J cn o cn o it* — ι i. _n ji. _n co M M M C0 M -π _n en cn --J --J cn -n cn cn co cn θN -J co co cn cn cn co cn _n -— i cn cn cn cn co cn cn -— 1 -— l -J cn -J cn cn cn co on oN — i cn cn cn co cn cn -— i cn oN cn co cn cn — J co cn co Ω Ω 3 2 Ω Ω Ω Ω 0 O Ω 3 0 0 O Ω Ω 0 0 Ω 3 Ω Ω Ω Ω 0 Ω Ω 3 3 3 Ω 2 Ω Ω Ω 0 0 Ω __; Ω Ω Ω 0 O Ω 3 Ω Ω Ω 0 0 Ω 3 0 0 0 pa pa pa pa pa pa pa > pa pa pa pa pa pa pa pa to pa pa pa pa pa to to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p μ3 μ3 μ 3 3 H H μ 3 3 ι-3 >-3 ι-3 H ι- >-3 H H μ 3 H >-3 ι-3 M. ι-3 3 H >-_ ι_l H !-3 μ 3 μ3 H ι-3 H H ι- H oooooo ooo oo ooooo oooooo oooooo oo oooo oo oo ooo ooo oo ooo oo ooo o o o 222222222222222222222222222222222222233332222222222222222 M MM M MM M MM M M MMM MM MMM MM MMMMM M M M MM M MM MM MMM M MMM M M M MMM M M M M-M M M M CO CO CO CO CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M o o o o o co cD CD CD Co cD D. cD CD Co co co co co co co co oo co Oo — — — — j — i — j — j - — j -— ι cn cn cn cn c ι cn _n cn cn -n cn _π C-π _π cn cπ cπ cπ cn cπ ιt. ιp. Ji. C0 M M O CD C0 -J cn Cn ιt* -0 M M O C0 C0 -J cn Cπ Ji. C0 M M O C0 C0 — J _n _π Ji. CO M M O CD CO -J cn Cπ ιt. _O M M O CO ∞ -J _n -π ιf* -O M M O CD CO Ω Ω Ω Ω Ω Ω a Ω Ω Ω a Ω Ω Ω Ω Ω Ω 3 3 Ω Ω Ω Ω Ω Ω Ω 3 Ω Ω Ω Ω Ω Ω Ω 2 3 Ω Ω 3 Ω Ω O Ω Ω Ω Ω Ω Ω O Ω Ω Ω Ω Ω O O Ω 03 pa pa Ω Ω 03 to INI to α Ω 03 π α Ω to to CO tO O O Ω 03 pa O O Ω tύ Ω Ω 03 M M M M M M M M > M M Ir* tr* Ir* tr* Ir* Ir* Ir* Ω Ω Ω Ω 3 ι-3 ι-3 ι-3 ι-3 ι-3 3 lr* tr* lr* lr* _-' lr* _- , _-* lr* _- | tr , lr* _- | lr* tr* lr , lr* EC EC Ea EC EC EC EECC EECC EECC EC Ir* _- 1 ir* tr , tr* lr* _- < lr* <; to Cd to td to to to tr* tr* _- , lr* EC EC EC EC Ea EC EC -O t tO - t tO tO tO H H M H .H. .H. HH HH HH H td M -O tO tO tO tO dO pa ≤ to μ to ≤ pa G G G G σ G G μ ι-< pa d po a p3 a d _ ω _o ω _ ω _ ω ω σ G σ σ σ G c ω _Q CωO -_ Q Q -_O C_O CcO CuO G-^ G_j G--i G-^ G G G α tr* Ir* Ir* pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to to pa pa pa pa pa pa to to pa pa pa to to pa pa to to to to to to to to pa pa pa p^ > M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M cn cn cn cri cn -n cn cn cn cn cn cn cn cn cn cn cn cN -n cn cn cn cn cn cn cn -n cn -n cn cn cn cn cn c^ -J -J —J — -J — l —I _n -n _n -n Cn _n cπ cπ _π _π cπ ιtι. i. ji. J!. ιi-. J-. j-. Ji. ji. co co co _O C C Cθ CO M M M M M M M M M M M M M M M M M M M M M M M M M M M M MM MM M M M M M M M M M M M M CO CO CO O M M O M M CO C. -J ON ifi. Ji- Cn _n -J cn cn cn cJi -n _n cn _n M M M CO CO i-* Ji. _n M M O O CD CO _n _n —J -J M -> CD _o co co - j co co if* cn c Ji* CO Cπ CO _n CO --J CD M O Ji> M Cn M ιt* Cn rø cn M CD J i . O -J C -0 0 0 _O CO Cθ -J M O M Ji. — J C0 Ji* -0 C0 C0 _. O Ji. -0 M _n M C0 -J Ji. cn i)i. -J C0 0N C0 CO cD _n M Ji. _o -— ι w u σι w ι ra μ ^ N) Ui M (. M Φ ^ ω M W i- * ϋi -i g ϋi u ij θJ fc θ M co Λ co ω o m ω -i M ιb o ∞ o θ w μ CO CO Ji* _O CO O M CO cn cO M Cn O O Ji- -J M iI i . Cn M -J CO -J cn ON M — J M -J C0 -J cn --I _n M O J-- M M -J --I M Cn -J -J Cn CD CD C0 CD Cn M M _n — J co cπ co I I .1 1 1 I I O M M C Cθ CO ιt* (_n cπ _n _n θN ιf* Cn --J cn cπ ( -θ M O O O M ιt* C0 M M M M M M M O O O M O M O O M M M M J-. CO CO Ji. M M CO Ji. Co cn J-. _0 m Cn O M M M Cn M M O CO M -O CO O. M CD M C__ -J --l _0 O M M _0 CD M C-N ιt* _0 M O M M M M O Cn Cn Cn C0 J^ M M C0 C0 _0 Cπ C0 M M Cn ιli. σN M CD O ω o θ *ι m Φ (_ μ -i ιfc φ Φ W -i ) u μ -ι co -i g u μ o p fc ^ . M -) μ μ o fe σι i. φ μ o ω -i N -. *ι μ _i tt) o cn sJ CO — l M CD Cn J i . CO M — -J J-- CO O M CO CO O M -J -J — I UI μ UI CD *• . I cn -J -J il-' Cn Cπ O C J-. Cn CO M M — J CO CO CO Cn O OD *-* — J CO O CD ιf* CO —l CO _n co I m m μ μ μ μ M M M θ cD cD Cθ _o crι _n cn cx ) co -θ _θ ιP* cθ -θ M M θ co o co co oN — J — J co — ι cn cn cπ m cn cn cn cn cπ cπ cπ ιt * i. M co co M Co M M Co co co M O —J — J Cπ _n M CO C0 ιt-. ι |i . CO C0 _n CO CO ON C0 _N CO M — I M CO CD O CX> ON ON CO M O CD --I M cn O -J U M i CD CO M it* M CO CO CO -J M _n cn Cn — J ιt* M 73 l co o cn cD M co M (_o -J M co co cπ -J θ Ji. M ιi-- cn cn cn cn .o co -J ω co M M _n o co ιt* _o cn co o o M co θ J-. c O ιt* _O CD O Ji. M -J CO cn θ _O CO _0 -O M _O Cn CD M en Cπ M ιf* M M C M --J O Cn C M O O CO ON O M C M M -J M — J CD M O Cn O M — — J CO CO M m M M M M μ μ μ μ μ μ μ μ μ μ -' -' l-' l-' l-' -' l-' l-' l-' l-' -> l- 1 l-> - -> -> l- 1 to O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M O CD CO -J -J -J — l CD CO — 1 ON CO CD 00 J-. — I -J -J CO CO -J — J -i ω J -J ON Uι m θN Ul ιl- ON ιft ω co t- J C0 03 CII ON -1 0N g θ O Φ Φ m *l lD O -J _j ω μ J i . ιt* l-J M Cπ CO -J O CO cn M cn μ ιf* CO ιt* _0 — J M O Ji. _O Ji. Ji. O O CO CD M Cn J-- M M O M cn CD O _O CO --J CO _n M it* M _n J-. O M M Cn M M O J-. M CO Cπ M M M CO ON M M cn J i . — l CO Cn _3 M J-. M cO O M Ji. CO M --l Cn cO ON CO — J cn M Cn CO Cn J-. O Cn O — J O J-. Cπ O_ _n M CO C O CO _n ιt-. CO M CO cn cn cn co oN cn -J co cn oN —i cn co cn co cn.cn -J -J cn cn cn cn co cn cn — J -n _n _n _n co _n -n --ι -J cn cn -J cn cn co cn cn ι cn cn cn -n cD cn cn -J cn cn cn co Ω Ω Ω O Ω Ω a θ Ω Ω 2 Ω O Ω O Ω Ω a a Ω Ω Ω Ω O Ω Ω 3 Ω Ω O Ω O Ω Ω a 3 Ω Ω 3 Ω Ω O Ω Ω a Ω Ω Ω Ω O Ω Ω 3 Ω Ω Ω O to pa pa pa > pa pa pa pa pa pa pa pa to pa pa pa pa pa to pa pa pa pa pa pa pa pa pa pa pa pa pa pa to to pa pa pa pa pa H - H - - β H -β β - . β „ . . . - . . . - . β β β . „ - . - . - - β - - β - β - β - β H - - . . H β - β ri - . . 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(-i) M M O CD C0 — J cn cπ ifs- CO M M O CD CO — cn cn Ω Ω 3 S O Ω Ω O Ω Ω 3 3 Ω Ω 2 Ω Ω O O O O O Ω Ω Ω O Ω Ω 3 Ω Ω Ω Ω O Ω Ω B O Ω Ω Ω Ω Ω Ω Ω O Ω Ω Ω O Ω Ω 3 Ω pa o O Ω 03 pa CO CO O O Ω td pa CO CO t_ Ω 03 pa O O Ω CO pa EC N tO tO O D Ω td pa 03 pa α M M M M M M M M M M M M M M pa pa pa pa pa pa pa py pa EC EC EC W Eα EC EC EC ffi ffi Ω Ω Ω Ω Ω Ω Ω Ω Ω Irr , _-* _ lr* _ H lr 1 - _^ _o _o co ω _o ω i-θ -o ω ω ω c Q H H H H H M M M H H _-' i-→ tr , _- | t* tr* _- | tr* _- | i7d W H H 2 3 2 a 2 3 3 3 2 3 3 3 Co W C _o co W M CO M CO G G a G G G G G G G G G G G G G G pa pu pO pd pO pd pd po pO pu pO pd pa pa pa pa pa G pa pa pa pa pa pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa pa pa pa pa to pa pa pa to to to pa M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M — J — j — j — j —i — j — j — — — ] ■ — i — — — i — i — j — i — i — j — i — j — j -j — j — j — i — j — j —i — j — i — ] — ! ■ — I — — i — J -— i — J cn oN cn oN ON ON ON cn cn cn cn cn cn oN cn cn cn cn J_- J_. il-. J-. CO CO CO CO CO CO CO C M M M M M M M M M M M M M M M M M M M O O O O O O O O CD CD CD CO CD CD -3 CO CO CD _3 CD CO CO CO CO CO -^ μ μ M CO _n cπ ιt* ji. o M θ M M _ M CJ _n _n _n _π cπ ιt* ι _o ιt* _π o _D θ θ -o _n -n -J -θ M -θ co co co _o ω o co σ c CO C M M O Ji. CO --l ιt* CO O CD --J CO O CO O M M ιI-. J-. CO — J CD CO M M — J M Cπ CD Cπ O CO Cπ O Cn CO Cπ M — J C5N CD M CD M Cn _n M M —l cn O CO CO Ji. CO O co cn M M cn cn -j cn cn co j_- o ji. cD θ cD θ cn j-. co co M Co cπ co M Cπ i. _o _n c-D cn cD _o -J M cπ o o co -j CO O CO CO CO CD M ON CO Ji. CD _O Cn O M C — I CO ' O O CO — J CO M CD ∞ CO M CJl OD O CXI M OO M Cπ CO -J CO CO O Cn CO CO CO OO ∞ — J O Cπ θ CO J-. M M -J CD CO I 1 I I I I I I I I I I I I I I I 1 I I I I 1 I M M M M M M O O M M O M O M O O O M CO CO CO M M O O M O. ιt* Cπ ιt* _O M M M M CO M CO M M M O O O O M ιt* M M M CO M m M Ji. _n M it* cn co _o _n co o M o o cn M M O O -J O CO M CD O -— l M C l Cn O O it* _O Ji. J-. _n M O Cn C — J M -J Cπ M Cn CD -J CD Cn M M CO CO CO M M co M CO M -J M M ιt* _n cθ Cπ M M O Cπ cθ ιt* M — J O M Cπ Cn M — J Ji. — J J*. — _0 0 -O CD -J CO CO _n co M CD O M M Cn Ji. CO ON M O _n CD — J M CD Cn CD CO CO cn co j-. ιt* co M Cn i-θ co co co co — J cn o CO Cn -J Cπ CO Cπ cn cn CO O CO O ∞ M -J M cn cn M M M ιt* M C O Cπ M Cπ M — I J=. Ji- CD M M CO M — J O M cn CO m m M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CO CD O CO CO CD O OO CO O M -— 1 -J ON — ! Cn ιt5- M M C0 C0 M C0 C0 C0 ιI-. M M M M _3 O O M C0 M O _3 O CD CD C0 C0 αD 00 —J C0 00 -J cn Cπ cn Cπ ji. C0 O 73 ∞ -i - M θ -i ϋ Ln [D - -) -i U φ Ji o μ φ Φ *i -i o ω o ω o m Φ si -J -) o μ μ o Φ -i oι o φ o μ μ w o * -. -i μ φ φ (j ϋι c CO CD O M cn Cπ M CO M ιli- Cn cn CO O -J _ M CO O _n C CD ON O M ιl-. O θ αN O — l M CO CO M Cn Ji- Cn cD ON CO M C CO M --l Cπ (-O ιIi. 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M Ji. co cn ιii. co o co M _n co co ιf* o ∞ M CD M μ _n μ M _3 M J i . cn ιt* _π cπ ιf* M _r) _o _o _o M _n co M _n co μ o o -j ι-* co — j μ μ co cD co μ M Co co μ co en cn — J -J co cn cn co cn cn — i -J cn en — l en cn co cn cn — J co co cn cn cn co _n _n --J -N cn 0 0 Ω 3 3 0 0 Ω 0 0 Ω 3 3 Ω Ω 2 Ω Ω 0 0 Ω 3 00 0 Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 0 Ω 3 00 Ω Ω Ω Ω Ω Ω 0 0 Ω 3 Ω 0 Ω Ω 3 Ω pa to to pa pa pa pa pa to to pa pa pa pa to to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to pa pa p - . ri - - - - H - - - β . . . - - . „ . . . . . . - . - . „ H . β . . . . . ι. - - - . - . - - H . . - . . - . - . ooooooooooooooooooooooooooooooooooooooooooooooooooooooooo 222222222222222222222222222222222222222222222222222222222 - i \-' t-' \-' i-' -> t- i }-> >-^ t- i l- Λ t- i \-' h-' t-' t- i h- i ^-' i-' h μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ M M M M M M M M M M M M M M M J_- ιt* Ji- Ji. ι[-- ιt* J-- Ji. Ji. Ji. Ji. Ji. ιt* Ji. ιt* Ji. J^ Ji. ιIi- _0 co co ω ω co co co co co co co co co -o co co co co co co co co co co co co co co co co ω M M M M M M M M μM OO OO OO OO OO OO OO OO OO OO CCDD C φ-Drj φCCDD CD φCD φCD φCD ωOO cCoO ω∞ cCoO mCO (C_O cCoO cCoO c-oO cCoO --j-J -—4 I -—. J -j -j -. g -J i -J m oN θN Cn m oN -i θN co-j _ntnιii ' _oMμocDco-j _ncnιt * _oMMθ -3 cCoo —- J i_-ojM M μM- ' ΓoN IcoO m_o —-JI''mcn iuniι _M. f_,ι Mwμ μ nθ iΦni c-o _. m ώ w μ o in CD * J m (f) _. I_ Ω Ω 3Ω ΩΩ Ω ΩΩ ΩO Ω Ω 3 o Ω Ω Ω Ω o Ω Ω a o Ω Ω Ω O Ω Ω Ω O Ω Ω 3 Ω Ω Ω Ω O Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω 3 3 0 0 Ω pa N H M O D Ω B ) pa ra to O Ω 03 pa 03 P 03 pa trJ O Ω t pa o σ Ω td pa O O Ω 03 M M M M M to M M M M M < "D Π3 T3 T3 D T3 D Π3 Π3 T3 Π3 Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω O toa ppaa toto to p a ir* t^ l^ lr^ l μ , μ tr* t tr* tr* tr , tr* pa pa pa pa tr* lr* lr , _- 1 lr* lr l lr* _- | lr* lr* _- ( lr* r* r-* - r* - p __a >.pp I _r-aa p *. _ Ir-aa pa to *. 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C O CD -n CD -0 _i M - M M M OD M -3 M CO M CO M CD Cn --I _n cn M CO CO CO CO C O CO CO CO Cn Cn iti. -J M CD J-. _^ CO cn C Ji. M O CO Ji. CO O O ON Cn -J J_. CD CO --l M M CO -- J CO — I M M M M M CO C O M CD Cπ O cn -J J-- Ji ' CO Cπ CO Ji. O M CO cn M O CO O Ji. cn M CO --J O CO — J Cn CO cn M CD Cn -— J Ui J * J * ID OJ - ] M C0 M O -J M M M O Ji * M _n _0 M M 0- Ji. 00 ιt * M M C0 μ μ C0 C0 J-. C0 μ c0 -0 CO it* cn if> M M CO M co M M M -O C Ji. i_* M _o _o it* _O it- cn _n - -- ι co co co cn --ι oo -J cπ _o -J _n cn -J --ι cn cn Ji. cn cn i. o o M M Ji. ιt* M M Co co co co m Ji> M -J CD O M CO ιt * Cn cθ Cn ιt* M M M Cn _π CO C3N M M M CO M M J^ -J O crι CO CO M M M CO O M -O Cπ CD Cπ Cn Cπ CXl C^ θ ιt=- co _n cD Co cD M _n co co cπ cπ μ --ι co μ M μ ∞ -j jι* cD --ι cD Cn M ιt* co θ ιi-. θN J-. — ι o M Φ -i φ μ μ * i- -i o t. u *, ι& * j uι o ι. o cii co *ι co μ -j o cπ co o cn ij — co co cn i. o co μ c-i θ ιto M co co cn -J θN CD _o --ι cD Cθ M on M — i co μ — μ μ co cn M Ji> cn co ω co on -J — I CO CΠ M M O — i cn I m μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ M M μ μ μ M M M M m — ι -_ oN J- ιf. -i _ι cn oN θN - ι cn cπ ιi-. μ o μ M μ co co M Cθ i. ιt* ji. cπ co oN σN Cθ CD θ θ θ θ M — j _n cn cn M C ιt* -π M ιt * co cn _n cn cn — J Co μ μ o H o co cn co co cn ιt* M μ co o cn co cD μ M o μ cπ co -j — J M ji* o J-. CD M Ji» --J μ μ cπ ιt* μ CD _o o cn cn o co M -J Ji. co μ co M M cπ M _o M Cn co _o 0 -i * l * 1 0 0 Ln .l CO φ CO O OO-Cπ Cπ M Cθ M CO M O O O O M O M _n M M ιf* O O Ji. Ji. _N CO CO CO Ji. CO M M M Ji- Cn ∞ CD CO _0 -J CO -J -J M CD M c U3 -J CB CD M Cθ μ cθ CO Cn M _n CD ON O CD -π Ji. Cn CO _n μ CD _n μ — l ιt* _3 ιt* CD --1 0 _0 -J CO _-. -J Cπ -J --I ιIi. Cn cD -J O O CO O O CD M ιf* 00 _0 _N μ θN m μ. μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ . μ μ μ μ M μ μ μ μ μ μ μ μ M IO O O O O OO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O OO OO O OO O O O O O OO OO O OO O O O O O O O O O O O O O O O OO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M μ μ μ μ μ μ M M M M M M M M M M M M M M M M M M M M M M M M μ M M μ μ M M μ μ μ μ μ μ μ μ μ M μ μ M M M M M Cn CO M — J -4 — J CO OO CD O CO.M μ M M μ μ M M M CO CO M O M M M μ M M μ O O CO O O CD CO O O CD CO CD CO CO OO OO CO CO O CD. D o o C μ μ O -— l M O M Cn ιfi. M M ιf * M ιt* M M Cn _n _N M CD — J O M ιf* C ιt* _n --J _n _0 _π co O cn CO M M -0 _n -O ι^ CO fc O μ *> M * J O J i - M M O _n CO CO —I O cn CD M O cn cn CO M M J-. Ji. — J Cn ιt* Cn M M M M CO CD O — J CD M CO _n ji. O -0 _n J-. CD M M Cn CO M M M cn cn -J cn cn cn cTi cn en cn co cn cn -— l oo co cn cn cn co en cn — J co en cn — J cn co cn oN -J cn co c^ Ω Ω 3 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 00 Ω Ω Ω 0 Ω Ω 3 0 Ω Ω 3 Ω 0 Ω Ω 3 Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω a a 0 Ω Ω to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p-) pa pa pa pa pa pa pa - β - β . . . - . - . H - - „ β - . . . 4 ^ . - - β . t. β . β . . . β . - . . H . . - . . . - . - . - . . . „ - . oooooo oooooooooooooooooo ooooo oo ooooo ooo oo oooooooooo oooooo 222222222222322222222222222222222323222222232222233322323 μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ M μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ |l_. lt* lf* ,- |t_ lf* lf* Ji. lt* !t* lt* tt* lt* lf-. lf l^ - j — J cn cn cn cn _n _n _n cn cn -n _π cπ cπ cπ cn cπ cπ cπ ( _π cn ιf^ cπ -. co M μ o co co — j _n cn j i. co M μ o cD Cθ — J -i -i ^ i- M μ o ra ffι Ui *' (_ ι μ o φ D *J cn ui fc i- W μ o (_ -J n uι fc ) i- μ θ φ Ω330ΩΩΩ0Ω03ΩΩΩ ΩΩ Ω0 Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω Ω Ω Ω O Ω Ω 3 2 Ω Ω Ω Ω O O Ω 3 O Ω Ω Ω Ω 3 Ω Ω Ω Ω pa tO to α Ω td pa N H H D O Ω W pa to t O Ω td pa O Ω 03 pa INI CO O Ω Cd pa Ω 03 to -J Ω to M M M M M M M μ M μ to Ω Ω Ω Ω Ω Ω Ω Ω Ω τ3 π3 τ3 π3 n3 τ3 π3 τ3 n3 D π3 Ω Ω Ω Ω Ω Ω Ω Ω Ω D D τ3 n3 D π3 η 3 _^ _ trr* tr* lr* t→ _- , _- | _ M M _-* t-* t^ _-i t-* _- i _-* tr* _- | EC EC EC EC tn EC EC En EC EC ED _- , M _-' _^ τ3 π_ 3 3 3 3 3 3 3 3 3 H I?d _O M _O H -0 _O H t?d _O G G σ G G G G G G O O O O O O θ ω ω co ω ω ω ω ω to pa p^ pa pa pa pa pa pa pa pa pa pa pa pa pa pa to to pa pa pa pa p ipa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa ^ μ μ M M M M M M M M M M M M M M M M M μ μ μ μ μ M M M M M M M M M M μ μ M μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ co co co co co -o co oo co co co co co co co αj co co co oa co co -o co co co ∞ cxi co co co ∞ CD _3 ∞ co co ∞ co co oo oo co — — j — j - j — 1 -— i — i — - - j _n cn cn cn cn cn cn cn cΛ l i l l ' l I CO o cn cn cn ιt * _π ι- * M θ o μ μ co cn _o co co μ μ μ o o μ μ o o o _π cπ ιt* i. -o o o μ μ o o o o μ J=* c J i > CO cn θN CD J i . Cθ μ M — Cπ CO μ M CO O CO CD -J ON CD -— l O M CD — J O CD -J Cπ CD M O CO O CO CO O - C _D — J ιt* M O Cπ -J -J Cπ CD M Ji. Ji. M J-. O Cπ CO O CO O ιii* -J μ co cn co M _o _π M cπ cD -J Cπ μ co _o o --- θ M θ θ co cn μ μ c —o c _D C_π M._ θ_ μ. θ _ o_ c —o - —-ιi c_ππ ccnn ccoo μ co cn o o M μ co cπ co — i co μ on M O CO μ — J θ cn -J Co _n _n co μ oN ιt* μ s. O M Cn μ u ) cn cn ιt* _o _o co ι^ M --ι μ co co cn co o μ -π cn _o cD Cπ o μ _rι 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I I I I I I I I I I I I I I I I I 1 I I I I I I I I M M μ M μ o o o μ o μ μ M O M O M O O M C ιt. ιl-. Cn Cn Ji. CO J-. CO M M CO CO CO M M M O O O O O O O M Cn.Ji. M M CO it* — J -J ON Ji. m cn co it- M Co i— ' co ιt. M - j ιt* co — J CO CO J-. M — . J β μ ra cn *ι W Λ ιb μ -i φ i Φ θ φ nN 'j _ι -j oj μ fc g o tn *ι j o j ιiN i- ji- o *' μ *' μ -i o O O C0 μ o O Cπ Cπ o C0 Ji. C0 C0 C0 ιt* J-. O — l Cπ _O J-. 0 --J --J Cπ cθ M CO CO O ιt* CO M Cn O O M M CD M cn --I μ θ CO CO CO _0 0 _n M CO -J θN Cn θN _0 co M — i , co co M it* _o cn it* _o co _o ciN M CD _n cn _O M -J M — J — J oN Cπ M cn cn — J — j o co M Cθ ji. cπ cπ cn cn M _n C-n cD CD Co M cπ ιi-. — m m μ μ μ μ μ μ μ μ μ μ J-. M CO CD CO CO CD M M O O O CO CO O μ σ o co Ji. ιt* cn oN — O CD — J cn co co it* — i cn cπ cn M M o if* cn — J θi -i uι -. ιt. ιt. -1 -i -i -- 1 — — J — M CO M O CN iϋ. -- 1 — J M CO CO — I -J M — 1 -— i μ CD CD Ji. μ CD CO _0 _O Cn M M CD CO — J J-> ON CD CD — i μ cn CO Cn — J Cπ O Oo μ ιt* Ji. O CO O CO — J cn co μ cD 73 CO O CO CD CO -J CO M CO CO Cn CD CO CD — l Cπ O CO Cn _π M CO _O M M CD CO _n M O tt-. M M — J it- Cn cD -J CO CO it* CO CO Cn ON M O M -J cn O M CO _n — 1 CN O c ON if* CD CO _O M CO O M O _n Cn M _n -J O O M CO --J CO _o _O Cn M Ji. J^ M it* CD -J CO Ji. O CD CO O CD M CO O CO CD Cn c^ m μ μ μ μ μ M M μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ ^ ^ -^ -^ ^ ^ μ μ μ μ μ μ μ μ μ to O O OO OO OOO O O OOO OO OOO O O O O O O O O O O OO OOO OO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO M M M M M M M M M CO Cn CO CD CO CO — J^ C-N _n Cn CO M CO M C _ M M J-. _0 _o cn —J —l -J Cn M CO J-. ιt * Ji- -π * fe -. cn — J θ J i . o co μ -. co σN Cθ ιt* σo cn co o cD — - ι μ ιt* o co M co cn μ cπ cD J-. cD co — ι cπ o μ _π co _n Ji. cπ o cD — J _o μ _π _n μ i. ιt* o σN CN Ji. _o μ co co o ιt* o co co cn M cn co J-. o — M co Co co —J co M co Ji> co co μ co co o o μ c_N Co M co J^ o co co o cn -J co co co cn J — co cn cn cn co oN ON — cn cn cn cn cn cn cn co cn cn — - J co co cn cn cn co cn cn — cn cn cn co cn cn — i — cn cn cn cn co cn cn — J co cn co cn oN — J cn cn cn co Ω 330 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 300 Ω Ω Ω 0 Ω Ω 2 Ω Ω Ω 0 Ω Ω 33 Ω Ω Ω Ω 0 Ω Ω 30 Ω 0 Ω Ω 3 Ω Ω Ω 0 pa pa pa pa pa pa pa pa pa to pa pa pa pa pa pa pa pa pa pa to to pa > pa pa to pa pa pa pa to to pa pa pa pa pa pa pa ps pa pa pa !- μ 3 3 ι-3 3 μ3 3 '-3 3 3 3 '-3 H 3 μ 3 ι-3 μ 3 H ι-3 ι- μ _ 3 3 H ι-- 3 H 3 μ 3 3 _ ι-3 μ 3 M 3 H O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 222222222222222222222222222222222222222222222222222222222 μ μ μ μ M M M M M M H-' M M μ-' μ μ M M M M M M M M M M M μ μ μ μ μ μ μ μ M M M M M M M M M M M I-' M M M M M M M M μ μ _n cn _π _n cn _n cn cn Cn cπ _n _π cn Cπ cn cn _n cn cn cπ _π cπ C-π _n _n cπ cn cn cπ c^ co co co M M M M M M M M M M μ μ μ μ μ μ μ μ μ μ o o o o o o o o o o co cD co cD CD CD CD Co cD _D ∞ co co cx co co co _o co _o -J -j — M μ o co co —i cn cn ιt* co M μ o cD co --ι cn cn ιt* co M μ o co ∞ -j cn cn ιt* co M μ o co co --j _^ Ω Ω Ω 0 Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 3 0 Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 0 0 Ω Ω 0 Ω Ω Ω td pa tO CO O Ω 03 pa σ Ω Ω tO pa O Ω Ω tO pa O O Ω CO pa N tO tO O O Ω tO pa O O Ω tO μ μ μ μ μ M μ M μ M H H M M M H Ω Ω Ω Ω Ω Ω Ω Ω Ω H H M H H M H H H H μ H H H H H pa pa pa pa pa pa pa pa iD π3 3 τ3 n3 3 τ3 D 'D iD π3 pa pa pa pa pa pa lrr' lr* lr* ir* tr* lr* tr , lr< lr* t-* rr* ir* tr* tr* lr* tr , tr* tr* lr* t^ lr' td trO td M C- M H C G G Q G G α σ α irO H K tO K M Cd M W to pa pa pa pa pa pa pa pa pa pa pa pa to to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa p^ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M CO CD CP CD CO CO CD CO CO CD CO CD CD CO CO CO CO CO CO -S CO Cσ co CD CO CO CO CD CO CΩ CO CΩ C^ Cπ cπ Cn Cn Cπ Cπ Cπ ιt* ιt* J i . J i . J i . ιv J_. ιt* J i . _0 -O CO _O CO CO CO CO M M M M M M M M M M M M M M M M O O O O O O O O O O O CO C^ I I I 1 1 1 1 1 1 1 I I CO CD CO CO cn cn cn Cπ O O O M M ιt* ιt* C CO it* ιIi. C ιI i . Cn CO CO M O M M M O M M O O O O O M O O O Ji- iϋ- CO CO M M M o o o o it* it* M c μ co μ co ji* _n -J _o o U -i u μ fc -i ι_ -i ι- o W ω * u i- (ii (S -i ιn A Φ W o o cD ω u ft -i -i w * ι o φ μ ft fc M co o J * ι oι CO -J CO O CO Cn CΩ O O — i Ji- M CO M CD Cn O CO O M CO CO M CO — J cn Cn M CO CO M O CO -— I Cn M Cn θ CO M M CO ιt* M M CO M M CO ιt* ιt* ιt * M _O M CO Cn θ CO co μ o cn M μ -J Co o ji- CD it* cn -j _o _n co co o M o cri -— i M _n cn o M M co cn _n _n μ — ι co cθ ιt- cn M -o co co co co co μ o co o -J co μ o co co —ι μ μ μ μ μ I I I I I I I I I I I I I μ M co μ o co o co co o μ co _3 cn cD --J co co oD -J on M cn co -. cn cn ιt* J-. _π Cn i. co co co M μ co M co μ o μ o o μ π Co Ji. . M μ m J^ M C0 CN O CD CD Cn -J Cπ O M CD CD C0 M C0 Cπ Ji. O M Cn C0 Cn CD M μ cn CD M — J O M Ji. --J C CO cn CO ' Cπ -J CD C -O M Cn C M -O Cn M -J Cn Ji. O O CD co =* — -_i co ιt* cD μ co M θ cπ i-o cn co μ ji. cn o M -J — J M co μ o cn co μ cn co c-N cn _n co cD θ cπ -θ co o θ ιt* _n cn — j o μ ∞ M cn cn μ co co cn M cn -J M CD θ cxι μ ∞ ιt* μ i . co co - j co - j c-- cn cD Co o co cn J i . cn co oo M M oo M M _o cD cn — i co co cn co co cn — i cD O M Co cn μ cn co it- co cD Co cD co if* m m μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ M μ co o μ μ cD CD CD o μ M M μ co co _n -J _n co co cπ ji . μ M M M ιt* i » j -. cπ co o_ _o co _n -n ON ιt* Cn Co Cπ Cθ ιt* cn cn Cn cn ιt. - Co CO ιt-. oN Cn -J cn oN C ι - j -J σN θ cn cn cπ o co μ cD μ cn --J cn J-. cN CD M co o o -. ∞ oo oN Co μ cD μ co cn co co M CD cn --! c^ 73 — l CO Cn Cn M CD M —I ι μi . CO CO CO C-J σ^ μ on cn cπ Cπ cπ ι* Cπ μ CD CO C J i . M O CXl M Cπ M --J CD Cn ∞ c μ cn cn co — J oN co o cn μ co oo μ M θ cπ ιii. μ μ ji. cπ co co μ o co cD Co o c-- co co μ o M M Ji. co M M Ji. ∞ c^ m M MM M M M M O O OO MMM M M M M M M M t- 1 i-^ t- 1 t-> to O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M MM M M M MM M MM M MM M M M MM M M MMM MM MMM M M MM CO MM MM MM M MMM MM MMM MM CO CO CO CO MM co M Co co cπ .ι-. ιt- o o o θ ιi i * cn ιt- ϊ. cn --i cn --J σ) it* cπ cn cπ cn -n cn c^ Cπ oN Cπ — J O O M O O O O — I ON CO Cn CO O CO M CO J i . ιt* O CO CO M CO M M CO — J M —I M M Ji- ON O CD ON M O CO CD — J ιt* C Cπ cθ -J J-- Cn --. M ON Cπ — J — ) O O M — J M CO O O O O CO — J CO M cD Ji- M -y cD CO — J Cri co M — Cn oN — J — 1 — J Cπ — J CO Ul CO ∞ CO M cn O CD ω cπ — l O M — I O cn — M M GJ Cπ oi cn cn co cn cn -J co co cn cn cn co oN cn — c- ON ON cn co cn cn — ] _ _ cN cn co σN c^ Ω Ω Ω 0 Ω Ω 300 Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω 0 Ω Ω 3 2 0 Ω Ω 0 Ω Ω 3 Ω Ω Ω Ω Ω Ω Ω 0 Ω Ω 3 0 0 Ω Ω 0 Ω to pa pato to pa papapapapa pa pa pa pato to pa papapa pa pa papapa to to toto pa pa topa p^ !- H H μ 3 3 ι-3 >^ ι-3 3 μ 3 H >-3 >-3 ι-3 3 3 μ - >-3 >-3 H 3 t-3 μ _ H3 μ 3 H H μ - 3 3 ι-3 3 ^ O O O O O O O O O O O O O O O O O O O ' O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O 222222222222222222222222222222222222222222222222222222222 μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ Cπ cn Cπ cπ cn cπ Cπ cn Cn cn Cπ cn Cn i-n Cπ cπ Cn cn Cn cπ Cπ cn cπ Cπ Ci Cn ' Cπ cπ C^ ∞ co o- co co ∞ ∞ co co cα — i cn cn cn oN ON O^ co co — i cn cn i. co M μ o cD co — J oN Cπ -. co M μ o cD cα -J cn cπ -. co M μ o co oD — i cn cn s. co M μ o cD co -J θN Cπ i. co 0 Ω 3 0 0 Ω Ω Ω Ω Ω Ω 0 0 0 3 0 Ω 0 Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω O O Ω Ω Ω O Ω Ω 3 0 0 Ω Ω Ω 0 Ω Ω 2 Ω Ω Ω O O Ω 3 Ω pa EC N tO CO σ O Ω tXl pa O O pa CO CO O Ω 03 pa to td α Ω CO pa CO CO O Ω 03 pa O Ω tύ pa σ M μ M μ M μ M μ M μ to to to to nS H H H H H H H μ 3 μ 3 H r J - Co ω ω C0 C0 Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω Ω τ3 D π3 π3 π3 τ3 π3 H t _r* t .* r _H l _r* κ; t- Hc; μ <; μ tt t?d H M M M lr* !r* --' l→ l→ lr* tr* !→ pa pa pa pa pO pd pO pO pσ pα pO pd pύ pύ pα pύ pα pύ pO pO pd pO G G G G G G G G α G G α G G G G G G G G α G G G G G α O O O O O O O tO to to pa to ^ pa > pa pa to to pa to pa > pa pa pa pa pa pa pa pa pa to to pa to to pa to pa pa pa pa pa > pa pa pa pa to pa to to M M M M M M M M M M M M M M M M M M M M M M μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ M M M M M M M M M M M M M M M O O O O O O O O O O O O O O O O O O O O O O CO CD CD CD CD CD CD CD CO CD CD CD CO CO CD CD CO CO CD CD CD CD CD CD CD -D CD CD CD CD CD CD ^ M M M M M M M M M M M M M M M M O O O O O O CD CD CD CD CD CD CD CO CD CO -O CO -O CO CO CO CO CO — 1 —1 — J -J — J — J -J -J -I ON ON ON ON ON ON ON -1 μ j μ i μ- μ- t l N - M M M M t- 1 -' >- i J >-> i-' t- Λ -^ t- i )-' [- i -' h- 1 b-' ^ t-^ h-' b^ i-' μ μ μ M M CO Ji- M O CD CD CO CO — 1 0N Cπ j-. 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Cn CO CO OO CD CD _^ m Cπ ιt* M M — J CD CO C — l σi -J O O O M CO CO O ιf * CD CO M M ιt* CO CO ι* CD M OD cn M CO Ji. C^ M Cn Ji. Cn M M CO Cn — I CO cn cn Ji- M CO Cn M CO M — — J M cn M C0 O cn cn M M cn C0 Cn C0 00 -J -J Cn cn C0 O Ji. M O C-n cri CD O ib Ji. M M CD M M Cn it. CO CD CO ' —l M CO M CO O O O Ji. ON ON CO M CO CO ON ON Cn O -J M M Cn M M CO Cn Cn CO -J CO aN O Cn it* M O M ON M Ji. — J O O CO CO Cn c M Cπ CO CO — i co cπ I m ■ I m M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M μ μ μ μ μ μ μ μ lμ μ μ μ μ μ μ μ μ μ μ μ μ μ μ ιt* M μ μ μ — ι cn cπ -. co M μ M μ o cD θN Cn cn cD co — j — J co μ co ^ j-. cn cn co — i -— i — j — ι —ι co co co co |, 1 -ι μ M M Ji. co Ji. ιi-. cn — J — i cn cn cn cn CO CO CO CD CD M Ji. O Cn CO CO J-. — J M — I — ! CO Ji. Cθ μ Cn Cn CD Ji. M μ cθ θ μ M — I CD Ji" --J CO ιf * O Cn CO -J cn --J Cn — 1 —J Ji. O C CD ON ON CD C M CO M CO 73 M CO — i μ CO M M ιt* Cπ O J-. Cn μ Cn cπ θN O CO — l Cn Cθ C O CO O O CD Cn cn cθ M CD M M Cn Cn O --I C O Ji. M σN CO Co μ μ Cn θN Ji. CO CD Cn — l ON if- M c μ- ji- μ cn M Co — J c3. — 1 — J θ μ cD CD θ ∞ M -J ιf* co o cn μ co M μ M M -J Cπ cπ M θ Cπ cθ ιt* co M -^ m M μ μ μ μ μ μ μ μ μ μ μ μ μ i- i -> l-' -> l-' l- i l-' t-' t- > -÷ i-> t-> l-> l- i -> t-' h-> i-> }- i t-> i- t-' t-' t-^ i-' to CO ooooooooooooooooooooooooσooooooooooooooooooooooooσooooooo ooooooooooooooooooooooooooooooooooooooooooooooooooooooooo CO CO M M M M M CO CO CO CO CO M M M M M M M M M μ M M M M M M M M M M M M M M M M M M M M M μ M M M M M M M M M M M M M ji - M co oN cn oN Cπ — 1 -J cn i . μ co cn M J i . ιi. M o μ μ cD μ μ μ cD co cD co cn cπ co μ M co M μ μ o μ M μ μ co o μ o o μ o o o o o θ M M θ M θ oo co cn cn o cπ μ oo co cD J i . co M co μ co μ o o μ -. — J — - J CD μ oN cn cn oo oo co μ o co M M o ' o π cπ tb J-. M CD CD M co co cD CO co cn co o cn M Cn co cn cn cπ co o o — i co μ cD ON M μ cn co o o — J cn o — i μ M — i co *. - ι co cn cπ -4 cn M μ co cD θN θ - * ιt * co o cn co μ co μ j-. μ — I M M CN cn cn cTi ∞ cn oN — I -J -J C-N — J cn cn cn co c-N ON — I W Ό Ω Ω 0 0 0 Ω 3 2 2 Ω 3 Ω 0 Ω 0 0 O 3 Ω 0 0 0 0 0 3 3 3 Ω 3 Ω Ω Ω 0 0 Ω 3 Ω Ω Ω 0 O Ω S 0 0 Ω Ω Ω Ω Ω Ω 0 0 Ω 3 0 0 to to pa pa pa pa to pa pa pa pa pa pa pa pa pa pa to pa pa pa to pa pa to pa pa pa pa pa pa to pa pa pa pa pa pa pa H 3 ι-3 3 3 ι^ H H rt H ι-_ H 3 ι-a 3 H μ 3 rt h3 H H H H H H 3 ι-3 rt 3 H H H ι-3 H ι-- ι-3 ι- H 3 OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 222222222222222222222222222222222222222222222222222222222 μ μ μ μ μμμ μμ μμ μ μ μ μμ μ μ co co co co co co co co co co co co αj co oo co co co - -- - — l -J — I — I — I — -J — — 1 — I -J — i — I -J — j — i — i — j — I -J — I — I — I -J — 1 —J — I — ! -J — 1 — I — I — i — i — j -j μ μ μ μ μ μ μ μ o o o o o o o o o o cD CD co cD Co co cD CD CD CD ∞ cD cxi co co co co co co co -j - —- i —— . -_ — , i —— , -— — . — i —— J. ucni ucni cn cn cn cn cn oN cn — J cn Cn J-. 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M CO M CD Cπ M C O -J cn M co σN M OO O --! M M M Cπ CD CD O M O Cπ CO CD M M M M Cn cD Cn O Ji. Ji. CO M M Ji. it* -J M -J it* CO CD Cn M OO Cn CO CO M M it* Cn CD Cn CO if* Cn CO M M M M M M M M M M M M M M M M M M M M i-^ t-> I- 1 I-' -' t-' I-' M M M M Cn co cn it* cn — O CO — J CO — l -J OO CO — J — 1 — J — l cn θ- CO CD Cn θN Cn cn Cπ ιt* CO O O M M CO M M M M O CD O O μ -. *. u co I- μ CO it* —1 —J m Cπ cD Cπ CD CU ιf* O CO — J O ON CD CO — J M — I CO — l CD O Cπ CO Ji. ON — O CJ Cπ θ Cπ cD C Cπ cθ C-N M CO O CO C M Ji. CO ∞ C-π cn M ON Ji. CO -J O OO O M J-. ON M C J-- CD O Ji. OO M ON — 1 0 -J M M CO CO ∞ CO CD CO M Ji. ιI-* ιl-. CO CO J-. CO CD Cn θN M M — J M ιt* CXI M -J Ji. — 1 — I cn M CO — 1 M — l CD Cn Ul ιt* M M CO — I Ji. CO M CO ∞ CO — ! (- C M CJl ιt* CO M Cn M M ιt* Cj Cπ CjJ O C M Ji. CO M M CO J-. 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CD Co θ M cn co cn — ι m ιb ft m -i θ -i o φ -i φ μ ( ji φ uι m co o W o θ M J m φ θ3 W w ^ -i M -i N -i Φ *i (ιi -i Φ -i c o o cD M O cn o cn — CD Cθ --) ιf* uJ Cθ co cn cD ιf* — J co — i vJ cn θ -ι -i φ Φ (_ μ ft uι J (_ . μ t- M θ ιjι -j co cJ o α W i- -i -j μ *. φ *. *. μ m μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ' μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ to CO o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o σ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o M M M M M M M M M M M M M M M M M M M M M M CO CO CO CO CO CO M M M M M M M M M M M M M M M M M M CO CO CO CO M M M M M CO CO μ M M μ M Co co ιb ιt* ιi-. cn cn cπ cn oN — ι co - - j - j co M M μ μ co oo -j co cn cπ cn cπ cn J-. M M M Co co Ji. co i. Cπ ) M o oo oN θN θN θN cn cπ CD M Cπ -J M O — I Cπ O CJl M M it.. CO O ON -J ιf* J i . O M OO M -J M CO ιIi. 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(_π c^ M M M M M M M M M M M M M M M M M M M M μ μ μ μ μ M μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ M M M M M M CO CO J-* CO CO CO ιt* C CO CO Ji. CO M M M CO M M M M O Cn Cπ Cπ cn — ! O CD CO -J ∞ co -J ∞ --l -J --l Cπ μ CO M Ji. ιli* Cθ M c l Ul Cπ Ji» CO M C CO M M c CO M M CD CO M M O Cπ j ι » -J cn — l Cn M cn M M -J Cn M CO M it* O Cn CO ON M -J un i. cn o co ιt* o -J M M ιt* co cn co cn co J=* co co co co o cn co o M --ι co i--- iM- cΦD tM- oo cmn tc!nnc_D c-ni θo θo Φco o_ »cn. cn. o * -- — — J . cni cπ. c _o_ j —i. co cn M co M M CO M — J M OO CD CO Cπ M Cjπ O M O CO M CO cn Cπ CO O cn CO O Cπ Cn CO CD CO CO O CD ON Cn M O Ji. CO O CO ON M CO Cn cO Ji* ON CD — 1 M M CO — 1 J=. O CD — I M CO M CO ∞ Ji. Cn Cπ ιI-. Cn θ Ji. M CO M M O CD Cn μ -J Cn O -J M Cθ μ M CD μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ M M M M μμ μ μμμ μ μμ μμ μ μ M Co -. co ji. CD — J co — j j=* cn θN Cπ M M M -. ji. ιt* ji. — j — j — i cn cn cn ji. 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ON O -J Cθ CO CD — J CO it* co co co cn μ — i co cD CD Cπ μ —J co cπ μ μ i- ^ - iιi Φ A -i m φ . -i o *J J θ θ θ fl Φ ω ω o Φ vi w ι μ θ -i o M . o o ιt> co -i m to M M M M M M M M M M - 1 ' h-" I- 1 M M M M μ μ_ι μi μi μi μi h^ h-> l-' l- l-' l-* t-> i- 1 -' i-^ - 1 ^ I-' O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O M M M M M M M M M M M M M M M M M M M M M M M M M μ μ M M M M M M M M M M M M M M M M M ιt* C C C0 C C0 M M M M M M M CD O CO CO Ϊ5 M Cθ μ θ -J CD CD CD CO CO -J CX ) CD 03 CX cn -J cn Ji. μ -J CO O O M M CO M M μ M μ C CO CO CO Co ω o o — i μ cπ μ — J co co -. cπ cn co cπ — o *• - J μ co cn o μ — i -J co o oN CD Cn oN O M ON cn - μ ι* cπ cD θN J-. co cπ cD θN Co j-. μ M co o oo co M M — J ιt* O CO M O Cπ Cπ M ιt* O ON O — ON M O M CO ON ON CO O O — J M Ji- OD — J CO m *. - O CO M M M U — oN On O M Ul Cn Ji. M O M ON — I CO — J O — CO — i co co cn cn co cn cn -J cn cn cn cD cn cn — i co co cn cn cn co cn oN — i cn oN cn cn co cn cn — J cn cn cn αD cn cn -J -J -J oN -J cn cn cn co cn cn — i co cn Ω 0 Ω Ω 200 Ω Ω 0 Ω Ω 3 Ω Ω Ω 0 Ω Ω 300 Ω Ω Ω 0 Ω Ω 2 Ω Ω Ω Ω 00 Ω 2 Ω Ω Ω 0 Ω Ω 222 Ω 2 Ω Ω Ω 0 Ω Ω 30 Ω pa pa pa pa pa pa pa to to to pa pa pa pa pa pa pa pa pa pa pa pa to to pa pa pa pa pa pa pa pa to P^ P^ H 3 μ 3 rt 3 H μ3 H ι-3 3 H H 3 ι-3 !_l μ 3 M 3 '-3 μ 3 3 H ι-3 μ 3 ι-3 H H 3 H 3 H 3 ι-- i-- i-3 3 OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO 223322222222222222222222232322222222222222222222222222222 μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ-μ μ μ μ μ μμ μ μ μ μ μμ μ μ μμ μ μ μ μ μ μ μ μ μ μ μ μ μ μ CD CD CO CO CD U3 CD CO CD -3 CD CD CO CO CD CO CO CO CD CO CD CO CO CO CD CD CD CD CD CD U5 CO ∞ I_ C M M M M M M M M M 3 M M M M M M M M M M O O O O O O O O O O CD CD CD CD -3 CO CD CO CD CD ∞ CO ∞ CO CO Cθ α- CO CO OO ^ μ θ Φ £θ -J Cn -i ft Ui M μ o ιo co . -i uι t> ι N) μ o φ co * i θN Cn ji. co M μ o cD co — J oN Cπ i. co M μ o cD Co — j -c cπ J-. co M μ o co co -j cn cn Ω O Ω Ω Ω Ω Ω a 3 Ω Ω Ω Ω Ω Ω Ω zziz n znn n on n O Ω Ω Ω Ω Ω Ω Ω O Ω Ω 2 0 0 Ω Ω Ω 0 Ω Ω Ω Ω Ω Ω a Ω o π Ω Ω to > IN! 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'. to pa pa pa pa pa to to pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa pa to to pa pa pa ' pa pa pa pa pa p^ M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M cπ cπ cπ cπ cπ cn cπ cπ cn uι cn cπ cn uι cπ cn cπ uι cπ cn cn cn i_ i. ιe. i. ι^ M M M M M M M M μ μ M M M μ O O O O O O O O CD CD CD CD CO CO CO CO CO CO CO CO -J — 1 — I — J -J -J . — O —N O -N O—N C.-n C.-n U.--| U.-l J-i. J -i. ι -t* J -i. ιE -i. J --. J -. J -i. M M M M M M M M M M M M M M M M M M M M M M M M M M M M μ μ M M μ μ μ M M M M M M M M M M M M M M M M M M M M M M CO θN ιt* cn ji. co co co ji. ' co ιt* ij ιt* i. ιt* cn cn cn cn cn cn ui ιt* μ co ιt* ιt-. M μ co co μ μ c ω ffl ω φ Φ U Φ in o uι ω μ ω _ι o cfl μ σι ui -i t M φ μ μ o3 m σι c!i μ o φ m iJi μ ι6, co o θN -- i ιt* o cn uι μ M o μ cn -J M -j oo o CO — l J=» θN ιt* cD M Cπ M Cθ co M Co i. cn Co o o cn co o — J — ι uι co oN Cθ θN Cθ co ιt. 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M M — 1 CO O — I CD C Cθ M cπ oo o co Cπ oN ιf* co ιt* Cπ M CN — l ON Cn — ON M CD M Cn CO M CD — CO Ji. CO μt* O ιf* co cn ui cn cn o o ji . ui M i-' co M o cD Co J i . -J -Ji. cn cn M CO — l M M C0 CD Cn Ji. CD CD CO O — I Ji* ON Cn CO M CO ON CD CO -i. M CO -J M Ji. CD CO Ul C M ∞ C0 C0 C0 O3 CX ) Cθ α3 CO O0 CX ) C0 CO CO C0 C0 C0 C0 00 CO C0 -J OO ON — l ON ON Cn — J Cn CO CO ON CN Cn Cn cN Cn cn cn CO ON ON -J — I — I ON — I ON ON ON CO ON ON —I OOOOOOOOOOOOOOOOOOOOO 3003ΩΩΩ3Ω00O ΩΩΩΩΩΩΩOΩΩ333Ω3ΩΩΩOΩΩ3 :OM 22 01 HOH Y 22 15,.011 -22,.594 9,.691 1..00 21,.01 8 O .TOM 23 01 HOH Y 23 2, .643 -7, .183 10 .821 1 .00 26, .23 8 O .TOM 24 01 HOH Y 24 15, .066 1. .849 16, .396 1, .00 19, .85 8 O .TOM 25 01 HOH Y 25 15, .126 -3. .402 16, .116 1, .00 19, .57 8 O LTOM 26 01 HOH Y 26 32, .656 2. .915 3, .918 1, .00 19, .80. 8 O LTOM 27 01 HOH Y 27 28, .202 -4. ,029 26, .810 1. .00 20. .30 8 O .TOM 28 01 HOH Y 28 16, .425 8. .911 9, .683 1. .00 20. .68 8 O ATOM 29 01 HOH Y 29 13 .191 -0, .276 16 .179 1 .00 21. .08 8 O ATOM 30 01 HOH Y 30 24, .468 13, .242 26, .524 1, .00 23, .31 8 O ATOM 31 01 HOH Y 31 13, .588 -18. .049 4, .960 1, .00 20. .13 8 O ATOM 32 01 HOH Y 32 35, .490 -6. .520 22, .597 1, .00 25. .94- 8 O ATOM 33 01 HOH Y 33 24. .980 20. .832 15, .135 1. .00 23, .73 8 O ATOM 34 01 HOH Y 34 17, ,830 -4. ,296 19. .108 1. ,00 21. ,03 8 O ATOM 35 01 HOH Y 35 19, .902 10. .374 15, .090 1, .00 21, .32 8 O ATOM 36 01 HOH Y 36 14. .598 16. .681 19, .217 1. .00 22, ,22 8 O ATOM 37 01 HOH Y 37 38, .054 3. .952 21, .350 1. .00 21, .27 8 O ATOM 38 01 HOH Y 38 5. .734 -7. ,825 7. .432 1. ,00 20, ,54 8 O ATOM 39 01 HOH Y 39 18. .556 -11. ,765 -3. ,800 1. ,00 22. ,03 8 O ATOM 40 01 HOH Y 40 20. .336 16. .185 12. ,754 1. ,00 26. ,13 8 O ATOM 41 "01 HOH Y 41 . 17, .638 -6. .870 17, .851 1. .00 27, .88 8 O ATOM 42 01 HOH Y 42 20, .695 16. ,322 15, .604 1. .00 21. .48 8 O ATOM 43 01 HOH Y 43 10. .008 6. ,471 2. .603 1. ,00 26. ,59 8 O ATOM 44 01 HOH Y 44- 27. .263 1. .931 31. .447 1. .00 22. ,23 8 O ATOM 45 01 HOH Y 45 9. ,253 21. ,264 13. .505 1. ,00 28. 25 8 O 45- Table TV. Functionally important residues in PaDDAH and the their equivalents in other superfamily members. + catalytic ## contact residue in AT, but not in DDAH * conserved in known members of family

Claims: CLAIMS 1. Use of the structural coordinates obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an arginine deiminase (DI) or a fragment thereof to X-ray diffraction measurements and deducing the structural coordinates from the diffraction measurements, to identify, screen, characterise, design or modify a chemical entity. 2. Use according to claim 1, wherein the DDAH is a bacterial DDAH. 3. Use according to claim 2, wherein the bacterial DDAH is Pseudomonas aeruginosa DDAH (PaDDAH). 4. Use according to claim 1, wherein the DI is a Pseudomonas aeruginosa DI (PaDI). 5. Use according to any one of the preceding claims, wherein the DDAH or DI is an inactive mutant of a wild- type DDAH or DI. 6. Use according to claim 5, wherein the DDAH or DI has been rendered inactive by mutating an amino acid equivalent to El 14, HI 62 or C249 of PaDDAH or PaDI to a different amino acid. 7. Use according to claim 6, wherein the different amino acid is alanine or a sterically similar amino acid. 8. Use according to any one of claims 5 to 7, wherein the crystal is a crystal of the DDAH or DI bound to a substrate or product. 9. Use of the structural coordinates set out in Table II to identify, screen, characterise, design or modify a chemical entity. 10. Use according to any one of the preceding claims, wherein the chemical entity is a modified DDAH or DI. 11. Use according to claim 10, wherein the modified DDAH or DI is inactive. 12. Use according to any one of claims 1 to 9, wherein the chemical entity binds to a DDAH or a DI. 13. Use according to claim 12, wherein the chemical entity is an inhibitor or an activator of a DDAH or a DI. 14. A chemical entity as defined in any one of the preceding claims. 15. A chemical entity as defined in claim 14 for use in a method for treatment of the human or animal body by therapy. 16. A chemical entity according to claim 15 for use in a method for treatment of a condition in which abnormal nitric oxide metabolism is implicated or for use in a method for treatment of a bacterial infection. 17. A method for identifying, screening, characterising or designing a chemical entity which is a modified DDAH or DI or binds to a DDAH or DI, which method comprises comparing a structural model of the DDAH or DI with a structural model for said chemical entity, and thereby determining whether said chemical entity is likely to be a modified DDAH or DI or bind to the DDAH or DI, wherein said structural model of the DDAH is derived from structural coordinates determined by subjecting to X-Ray diffraction measurements a crystal comprising a DDAH or DI as defined in any one of claims 1 to 8 or a fragment thereof. 18. A chemical entity identified by a method according to claim 17. 19. A chemical entity according to claim 18 for use in a method for treatment of the human or animal body by therapy. 20. A chemical entity according to claim 19 for use in a method for treatment of a condition in which abnormal nitric oxide metabolism is implicated or for use in a method for treatment of a bacterial infection. 21. A pharmaceutical composition comprising a chemical entity as defined in claim 14 or a chemical entity according to claim 18 and a pharmaceutically acceptable carrier or diluent. 22. A method for treating a host suffering from a condition in which abnormal nitric oxide metabolism is implicated or a bacterial infection, which method comprises administering to the host a therapeutically effective amount of a chemical entity as defined in claim 14 or a chemical entity according to claim 18. 23. A method for identifying the presence or absence of an asymmetrically methylated arginine derivative in a sample, which method comprises: (a) contacting the sample with a DDAH as defined in any one of claims 5 to 7, a modified DDAH as defined in claim 10 or 11 or a modified DDAH identified by a method according to claim 17; and (b) determining whether the DDAH binds to an asymmetrically methylated arginine derivative. 24. A crystal comprising a DDAH or a fragment thereof or a DI or a fragment thereof. 25. A crystal according to claim 24, wherein the DDAH is a DDAH as defined in any one of claims 1 to 3 or 5 to 8. 26. A crystal according to claim 24, wherein the DI is a DI as defined in any one of claims 1 or 4 to 8. 27. A method for preparing a crystal, which method comprises forming a crystal of a substance comprising a DDAH as defined in any one of claims 1 to 3 or 5 to 8. 28. A method for preparing a crystal, which method comprises forming a crystal of a substance comprising a DI as defined in any one of claims 1 or 4 to 8. 29. A DDAH or DI as defined in any one of claims 5 to 8. 30. A machine readable data storage medium comprising a data storage material encoded with machine readable data which when read by an appropriate machine is capable of displaying a three dimensional representation of a crystal as defined in claim 24 to 26.

Inventors: LEIPER JAMES MITCHELL, MCALISTER MARK, MCDONALD NEIL, MURRAY-RUST JUDITH, VALLANCE PATRICK JOHN THOMPSON, LEIPER, JAMES, MITCHELL, MCALISTER, MARK, MCDONALD, NEIL, MURRAY-RUST, JUDITH, VALLANCE, PATRICK, JOHN, THOMPSON
Applicants: LEIPER JAMES MITCHELL, MCALISTER MARK, MCDONALD NEIL, MURRAY RUST JUDITH, UNIV LONDON, VALLANCE PATRICK JOHN THOMPSON, LEIPER, JAMES, MITCHELL, MCALISTER, MARK, MCDONALD, NEIL, MURRAY-RUST, JUDITH, UNIVERSITY COLLEGE LONDON, VALLANCE, PATRICK, JOHN, THOMPSON
Application year: 2001
Main classification: C12N15
IPC codes: A61K38, A61K45, A61P3, A61P9, A61P13, A61P17, A61P19, A61P25, A61P29, A61P31, A61P35, A61P43, C12N9, C12N15, C12Q1, G01N23, G01N33