PROCESS FOR THE PREPARATION OF (R)-2-ALKYL-3-PHENYL-1-PROPANOLS

Abstract: Compounds of formula (I), wherein R1 and R2 are, independently of one another, H,C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxy, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yiedls by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R-CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leaving group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and reduction to corresponding 3-R-2-R3-allyl alcohols and their enantioselective hydrogenation, wherein R is (a).

Description: Process for the preparation of (R) -2-alkyl-3-phenyl-l~ propanols The invention relates to a stereoselective process for the preparation of (R) -2-alkyl-3-phenyl-l-propanols and new intermediate products obtained in the process steps. In EP-A-0 678 503, δ-amino-γ-hydroxy-ω-aryl-alkanecarbox- a ides are described which exhibit renin-inhibiting properties and could be used as antihypertensive agents in pharmaceutical preparations. The manufacturing processes described are unsatisfactory in terms of the number of process steps and yields and are not suitable for an industrial process. A disadvantage of these processes is also that the total yields of pure diastereomers that are obtainable are too small. In a new process, one starts from 2, 7-dialkyl-8-aryl-4- octenoyl amides, whose double bond is simultaneously halogenated in the 5-position and hydroxylated in the 4-position under lactonization, then the halogen is substituted by azide, the lactone amidated and the azide then transferred to the a ine group. The desired alkanecarboxamides are obtained with the new process both in high total yields and in a high degree of purity, and selectively pure diastereomers can be prepared. The halolactonization of process step a) , the azidation of process step b) , and the azide reduction of process step d) are described by P. Herold in the Journal of Organic Chemistry, Vol. 54 (1989), pages 1178-1185. The 2, 7-dialkyl-8-aryl-4-octenoyl amides may correspond for example to formula A, and especially to formula Al wherein Ri and R 2 are, independently of one another, H, Cι-C 6 alkyl , Cι-C 6 halogenalkyl , Cι-C 6 alkoxy, Cι-C 6 alkoxy-Cι- C e alkyl , or Cι-C 6 alkoxy-Cι-C 6 alkyloxy, R 3 is C -C 6 alkyl , R 4 is Cι-C 6 alkyl, R 6 is Cι-C 6 alkyl , R 5 is Ci-Cealk l or d-C 6 alkoxy, or R 5 and R 6 together are tetramethylene, pentamethylene, 3-oxa-l , 5-pentylene or -CH 2 CH 2 0-C ( 0) - substituted if necessary with Cι-C 4 alkyl , phenyl or benzyl . The compounds of formulae A and Al are obtainable by reacting a compound of formula B as racemate or enantiomer, with a compound of formula C, as racemate or enantiomer, wherein Ri to R 4 , R 5 and R 6 are as defined above, Y is Cl, Br or I and Z is Cl, Br or I, in the presence of an alkali metal or alkaline earth metal. Y and Z are preferably Br and especially Cl. The compounds of formula B are known from EP-A-0 678 503. The compounds of formula C may be prepared from amidation of the corresponding carbonic esters, amides, or halides. The formation of carboxamides from carbonic esters and amines in the presence of trialkyl aluminium or dialkyl aluminium halide, for example using trimethyl aluminium or dimethyl aluminium chloride, is described by S. M. Weinreb in Org. Synthesis, VI, page 49 (1988) . The carbonic esters are obtainable by the reaction of trans-1, 3-dihalogenpropene (for example, trans-1, 3-dichlorepropene) with corresponding carbonic esters in the presence of strong bases, for example alkali metal amides. A satisfactory solution for the stereoselective preparation of compounds of formula B has not yet been found, especially with regard to an industrial process. Surprisingly it has now been found that 2-alkyl-3-phenylpropionic acids can be stereoselectively prepared with high yields in only three process steps. When suitably substituted benzaldehydes are condensed with carbonic esters to form 2-alkyl-3-hydroxy-3- phenylpropionic acid esters, the desired diastereomers are obtainable in surprisingly high yields mostly as crystalline compounds which can be readily isolated. After conversion of the hydroxy group to a leaving group, 2-alkylcinnamic acid esters are then formed by elimination with strong bases with surprisingly high regioselectivity. The allyl alcohols obtained after hydrogenation can in turn be hydrogenated in the presence of certain catalysts to form practically enantiorαer-pure 2-alkyl-3-phenyl-l-propanols . These alcohols can then be converted by halogenation to the compounds of formula B in a manner known per se. The object of the invention is a process for the preparation of compounds of formula I, wherein Ri and R 2 are, independently of one another, H, Ci- C 6 alkyl , Cι-C 6 halogenalkyl, Cι-C 6 alkoxy, Cι-C 6 alkoxy-Cι-C 6 - alkyl, or Cι~C 6 alkoxy-Cι-C 6 alkyloxy, and R 3 is Cι-C 6 alkyl, comprising a) the reaction of a compound of formula II wherein R α and R 2 are as defined above, with a compound of formula III, (III), \ ^ COOR, R 3 ^ wherein R 3 is as defined above, to form a compound of formula IV, wherein R 7 is Cι-Cι 2 alkyl, C 3 -C 8 cycloalkyl, phenyl or benzyl , b) the isolation of the crystalline compound of formula IV, the conversion of the OH group to a leaving group, and the reaction of a compound containing a leaving group in the presence of a strong base to form a compound of formula V, c) the reduction of carbonic esters of formula V to form the alcohol of formula VI, d) the hydrogenation of the alcohol of formula VI in the presence of hydrogen and catalytic quantities of a metal complex as asymmetric hydrogenation catalyst, comprising metals from the group of ruthenium, rhodium and iridium, to which the chiral bidentate ligands are bonded, to form a compound of formula I. Ri and R 2 may be a linear or branched alkyl and preferably comprise 1 to 4 C atoms. Examples are methyl, ethyl, n- and i-propyl, n-, i- and t-butyl, pentyl and hexyl. Ri and R 2 may be a linear or branched halogenalkyl and preferably comprise 1 to 4 C atoms, 1 or 2 C atoms being especially preferred. Examples are fluoromethyl, difluoro- itiethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, 2-chloroethyl and 2, 2, 2-trifluoroethyl . Ri and R may be a linear or branched alkoxy and preferably comprise 1 to 4 C atoms. Examples are methoxy, ethoxy, n- and i-propyloxy, n-, i- and t-butyloxy, pentyloxy and hexyloxy. Ri and R 2 may be a linear or branched alkoxyalkyl. The alkoxy group preferably comprises 1 to 4 and especially 1 or 2 C atoms, and the alkyl group preferably comprises 1 to 4 C atoms. Examples are methoxyrαethyl, l-methoxyeth-2-yl, 1- methoxyprop-3-yl, l-methoxybut-4-yl, methoxypentyl, methoxy- hexyl, ethoxymethyl, l-ethoxyeth-2-yl, l-ethoxyprop-3-yl, 1- ethoxybut-4-yl, ethoxypentyl, ethoxyhexyl, propyloxymethyl, butyloxymethyl, l-propyloxyeth-2-yl and l-butyloxyeth-2-yl . Ri and R 2 may be linear or branched Cι-C6alkoxy-Cα-C 6 alkyloxy. The alkoxy group preferably comprises 1 to 4 and especially 1 or 2 C atoms, and the alkyloxy group preferably comprises 1 to 4 C atoms . Examples are methoxy ethyloxy, 1-methoxyeth- 2-yloxy, l-methoxyprop-3-yloxy, l-methoxybut-4-yloxy, methoxypentyloxy, methoxyhexyloxy, ethoxy ethyloxy, 1- ethoxyeth-2-yloxy, l-ethoxyprop-3-yloxy, l-ethoxybut-4- yloxy, ethoxypentyloxy, ethoxyhexyloxy, propyloxymethyloxy, butyloxymethyloxy, l-propyloxyeth-2-yloxy and 1-butyloxyeth- 2-yloxy. In a preferred embodiment, R α is methoxy-Cι-C 4 alkyloxy or ethoxy-Cι-Calkyloxy, and R 2 is preferably methoxy or ethoxy. Quite especially preferred are compounds of formula I, wherein Ri is l-methoxyprop-3-yloxy and R 2 is methoxy. R 3 may be a linear or branched alkyl and preferably comprise 1 to 4 C atoms. Examples are methyl, ethyl, n- and i-propyl, n~, i- and t-butyl, pentyl and hexyl . In a preferred embodiment, R 3 in compounds of formula I is isopropyl . Especially preferred are compounds of formula I wherein Ri is methoxy-n-propoxy, R 2 is methoxy and R 3 is isopropyl. R 7 is preferably Cι-C 6 alkyl, Cι-C 4 alkyl being especially preferred; some examples are methyl, ethyl, n-propyl and n- butyl. The starting compounds of formulae II and III used in process step a) are known or can be prepared in a manner similar to known processes. Compounds of formula II are described in EP-A 0 678 503. The reaction is advantageously carried out at low temperatures, for example 0-40 °C, in the presence of at least equivalent quantities of strong bases. The reaction is further expediently carried out in a solvent, ethers such as diethyl ether, tetrahydrofuran and dioxane being especially suitable. Suitable strong bases are in particular alkali metal alcoholates and secondary amides, such as lithium diisopropylamide . The desired diastereo er of formula IV is surprisingly formed up to about 75%. The compounds of formula IV are surprisingly crystalline and can therefore be readily isolated without any substantial losses by means of extraction and crystallization. The conversion of the OH group to a leaving group in reaction step b) is known per se. Reaction with carboxylic acids or sulfonic acids, or their anhydrides (acylation) , is especially suitable. Some examples of carboxylic acids are formic acid, acetic acid, propionic acid, benzoic acid, benzenesulfonic acid, toluenesulfonic acid, methylsulfonic acid and trifluoromethylsulfonic acid. The use of acetic acid anhydride has proved especially successful. The elimination is expediently carried out in the presence of strong bases, alkali metal alcoholates such as potassium t- butylate being especially suitable. The presence of solvents such as ethers is expedient. The reaction is advantageously carried out at low temperatures, for example 0-40 °C. It is of advantage to conduct the elimination reaction directly in the reaction mixture for acylation. The elimination leads to the desired Z isomers with surprisingly high regioselectivity. These isomers are crystalline and can therefore be readily isolated without any substantial losses by means of extraction and crystallization. The yields are above 80%. Process step d) is preferably carried out at low temperatures, for example -40°C to 0°C, and advantageously in a solvent. Suitable solvents are, for example, hydrocarbons (pentane, cyclohexane, methylcyclohexane, benzene, toluene and xylene) . For hydrogenation, metal hydrides are expediently used in at least equimolar quantities, for example LiH, NaH, NaBH 4 , LiAlH, and alkyl metal hydrides such as methyl, ethyl, or isopropyl aluminium dihydride or tin trihydride, dimethyl, diethyl, triisopropyl or triisobutyl aluminium hydride or tin dihydride, and tributyl tin hydride. The compounds can be isolated by means of extraction and purified by means of distillation. The yields amount to more than 90%. The asymmetric hydrogenation in process step d) of α,β- unsaturated carboxylic acids with homogeneous, asymmetric hydrogenation catalysts is known per se and described for example by John M. Brown in E. Jacobsen, A. Pfaltz, H. Yamamoto (Eds.), Comprehensive Asymmetric Catalysis I to III, Springer Verlag, 1999, pages 121 to 182. Especially effective are ruthenium and rhodium catalysts . Chiral ditertiary diphosphines whose phosphine groups in the 1,2, 1,3 or 1,4 position are bonded to a C 2 -C 4 carbon chain are often used as ligands. The skeletal structures of the chiral ditertiary diphosphines may be acyclic, monocyclic or polycyclic. The phosphine groups may be substituted with the same or with different, preferably the same, substituents selected from the group of Cι-C 8 alkyl, C 3 -C 8 cycloalkyl, C 6 - Cι 2 aryl, and C 6 -Cι 2 aryl- Cι-C 4 alkyl. Cycloalkyl and aryl may be unsubstituted or substituted with Cι-C 4 alkyl, Cι-C 4 alkoxy, Ci- C 4 fluoroalkyl or C-Cι 2 secondary amino . Suitable phosphine groups are also phosphanyl, preferably five-member phosphanyl, which if necessary is substituted in one or both α-positions with C α -C 4 alkyl or Cι-C 4 alkoxy. Some examples of chiral ditertiary diphosphines are (R" 2 P is for example diphenylphosphino or dicyclohexylphosphino, substituted if necessary) 1, 2-Di-R" 2 P-propane, 2, 3-Di-R" 2 P- butane, 1 , 2-Di-R" 2 P-norbornane or -norbornadiene, 1 , 2-Di- R" 2 P-cyclopentane, 1, 2-Di-R" 2 P-N-methylpyrrolidine, 2 , 2 ' -Di- R" 2 P-biphenyl or -binaphthyl, 2 , 2 ' -Di-R" 2 P-6-methyl or -6, 6 ' - dimeth lbiphenyl, 2 , 2 ' -Di-R" 2 P-6-methoxy or -6, 6 ' -dimethoxy- biphenyl, and 1- (α-R" 2 P-ethyl) -2-R" 2 P-ferrocene . Good optical yields are achieved using metal complexes of formula VII or Vila, [LMeYZ] (VII), [LMeY] + E ~ (Vila), wherein Me is rhodium; Y stands for two olefins or one diene; Z is Cl, Br or I; E ~ is the anion of an oxygen acid or a complex acid; and L is a chiral ligand from the group of ditertiary diphosphines, in which the phosphine groups are bonded to a C 2 -C 4 chain of the diphosphine backbone chain, and the diphosphine forms a five to seven-member ring together with the rhodium atom. Where Y stands for two olefins, they may be C 2 -Cι 2 olefins, C 2 -C 6 olefins being preferred and C 2 -C 4 olefins being especially preferred. Examples are propene, but-1-ene and especially ethylene. The diene may comprise 5 to 12 and preferably 5 to 8 C atoms and may be an acyclic, cyclic or polycyclic diene. The two olefin groups of the diene are preferably linked by one or two CH 2 groups. Examples are 1, 3-pentadiene, cyclopentadiene, 1, 5-hexadiene, 1, 4-cyclohexadiene, 1,4- or 1, 5-heptadiene, 1,4- or 1, 5-cycloheptadiene, 1,4- or 1,5- octadiene, 1,4- or 1, 5-cyclooctadiene and norbornadiene. Y represents preferably two ethylene or 1, 5-hexadiene, 1,5- cyclooctadiene or norbornadiene. In formula VII, Z is preferably Cl or Br. Examples of E 1 are C10 4 " , CF 3 S0 3 " , CH 3 S0 3 " , HS0 4 ~ , BF 4 ~ , B (phenyl) 4 " , PF 6 " , SbCl 6 ~ , AsFff or SbF 6 " . It was found that ligands with a biphenyl backbone are especially suitable for the asymmetric hydrogenation of compounds of formula VI. With these ligands in the metal complexes of formulae VII and Vila, optical yields of at least 95% ee can be achieved, which represents a substantial cost saving for manufacture on an industrial scale. In process step d) , therefore, it is preferred to use metal complexes of formulae VII and Vila, wherein L represents the ligands of formula VIII, wherein m and n in each case are 0 or an integer from 1 to 4, and R 8 and R 9 are hydrogen or the same or different substituents, selected from the Cι-C 4 alkyl and Cι-Calkoxy group; and Xi and X 2 are, independently of one another, secondary phosphino. Substituents are preferably bonded in the 6 position or the 6, 6' positions . s an alkyl, R 8 and R 9 may preferably comprise 1 to 2 C atoms. Linear alkyl is preferred. Examples of R 8 and R 9 as an alkyl are methyl, ethyl, n- and i-propyl, n-, i- and t-butyl. Methyl and ethyl are preferred, and methyl is especially preferred. s an alkoxy, R 8 and R 9 may preferably comprise 1 to 2 C atoms. Linear alkoxy is preferred. Examples of R 8 and R 9 as an alkoxy are methoxy, ethoxy, n- and i-propoxy, n-, i- und t-butoxy. Methoxy and ethoxy are preferred and methoxy is especially preferred. The Xi and X 2 groups may be different or preferably the same and correspond to formula PRι 0 Rn, wherein Rio and R n are the same or different and represent branched C 3 -C 8 alkyl, C 3 -C 8 cycloalkyl, or unsubstituted or phenyl substituted with one to three Cι-Calkyl, Cι-C 4 -alkoxy, or -CF 3 . Special preference is for ligands of formulae VIII, wherein Xi and X 2 are a PR 10 Ru group, wherein R α0 and Rn in each case are cyclobutyl, cyclopentyl, cyclohexyl, phenyl or phenyl substituted with 1 or 2 methyl, methoxy or CF 3 . The metal complexes used as catalysts may be added as separately prepared isolated compounds, or also formed in situ before the reaction and then mixed with the substrate to be hydrogenated. It may be advantageous in the reaction using isolated metal complexes to add additional ligands, or in the in situ preparation to use surplus ligands. The surplus may for example be up to 10 moles and preferably 0.001 to 5 moles, based on the metal complexes used for the preparation. Process step d) may be carried out at low or elevated temperatures, for example at temperatures from -20 to 150°C, preferably from -10 to 100°C, ■ temperatures of 10 to 80°C being especially preferred. The optical yields are generally better at low temperatures than at high temperatures . The process according to the invention may be carried out at normal pressure or preferably under positive pressure. The pressure may for example range from 10 5 to 2xl0 7 Pa (Pascal) . Catalysts are preferably used in quantities from 0.0001 to 10 mol-% based on the compound to be hydrogenated, the range 0.001 to 10 mol-% being especially preferred and the range 0.01 to 5 mol-% being preferred in particular. The preparation of catalysts as well as process step d) and the other process steps may be carried out in the absence or the presence of an inert solvent, wherein one solvent or a mixture of solvents may be used. Suitable solvents are, for example, aliphatic, cycloaliphatic and aromatic hydrocarbons (pentane, hexane, petroleum ether, cyclohexane, methylcyclo- hexane, benzene, toluene, xylene) , aliphatic halogenated hydrocarbons (dichloromethane, chloroform, di- and tetrachloroethane) , nitriles (acetonitrile, propionitrile, benzonitrile) , ethers (diethyl ether, dibutyl ether, t-butyl methyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, diethylene glycol dimethyl ether, tetrahydrofuran, dioxane, diethylene glycol monomethyl or monoethyl ether) , ketones (acetone, methyl isobutyl ketone) , carbonic esters and lactones (ethyl or methyl acetate, valerolactone) , N-substituted lactams (N-methylpyrrolidone) , carboxamides (dimethylamide, dimethylformamide) , acyclic ureas (dimethylimidazoline) , and sulfoxides and sulfones (dimethyl sulfoxide, dimethyl sulfone, tetramethylene sulf- oxide, tetramethylene sulfone) and alcohols (methanol, ethanol, propanol, butanol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, diethylene glycol monomethyl ether) and water. The solvents may be used alone or in a combination of at least two solvents. The reaction may be carried out in the presence of co- catalysts, for example quaternary ammonium halogenides (tetrabutylammonium iodide) and/or in the presence of protonic acids, for example mineral acids. Using the regioselective and enantioselective process according to the invention, the intermediate products of the formula (B) may be prepared via all process steps in yields of at least 50% by weight, based on the compounds of formula II. The high total yields make the process suitable for industrial use. A further object of the invention relates to the compounds (intermediates) of formula VI, wherein R l r R 2 and R 3 are as defined hereinbefore, A further object of the invention relates to the compounds (intermediates) of formula IV, wherein R l r R 2 , R 3 and R 7 are as defined hereinbefore The embodiments and preferences described hereinabove apply for R α , R 2 , R 3 and R 7 . The following examples explain the invention in more detail. A) Preparation of (R) -3- [4 ' -CH 3 0-3 ' - (CH 3 Q (CH 2 ) 3 0) -phen-1-yl] - 2-isopropylpropan-l-ol (A4) Example Al : Preparation of (Ai ; A solution of 436 ml diisopropylamine and 2.6 1 tetrahydrofuran is cooled to -20 °C, and 1.234 1 n-hexyl lithium (2.5 M in hexane) is added dropwise over a period of 15 minutes. A solution of 368 g ethyl isovalerate in 1.7 1 tetrahydrofuran is added dropwise over a period of 15 minutes at -20°C. After a further 10 minutes, a solution of 584 g 4-methoxy-3- (3-methoxy-propoxy) benzaldehyde (EP 0 678 503) in 1.7 1 tetrahydrofuran is added drop by drop and stirred for 40 minutes at -20°C. Then 2.15 1 saturated aqueous ammonium chloride solution is added drop by drop and extracted with ethyl acetate (2 x 8 1). The organic phases are washed consecutively with 0.5 N hydrochloric acid (Ix 4.3 1), water (lx 4.4 1) and brine (lx 4.4 1). The combined organic phases are dried over sodium sulfate (1.6 kg), filtered and boiled down in a rotary evaporator. By means of crystallization from ethyl acetate (1 1) and hexane (11 1) title compound Al is obtained from the residue as a white solid (656 g, 72 %) : α H-NMR (400 MHz, DMSO-d 6 , δ) : 0,90 - 1.04 ( , 9H) , 1.97 ( , 2H) , 2.32 ( , 1H) , 2.58 (m, 1H) , 3.28 (s, 3H) , 3.50 (m, 2H) , 3.74 (s, 3H) , 3.82 (q, 2H) , 3.98 (m, 2H) , 4.57 (m, 1H) , 5.30 (d, 1H) , 6.75 - 6.90 ( , 3H) ppm. Example A2 : Preparation of A solution of 20 g Al and 0,4 g 4-dimethylaminopyridine in 100 ml tetrahydrofuran is cooled to 0°C, 6.3 ml acetic acid anhydride is added dropwise and the reaction mixture stirred for 1 hour. A solution of 19.0 g potassium t-butylate in 140 ml tetrahydrofuran is added drop by drop over a period of 30 minutes at -2°C to 0°C and then stirred for 2 hours at 0°C. Then 250 ml t-butyl methyl ether and 250 ml iced water are added to the reaction mixture. The organic phase is separated off and the aqueous phase extracted again with 250 ml t-butyl methyl ether. The organic phases are washed consecutively with 250 ml water and 250 ml brine. The combined organic phases are dried over magnesium sulfate (50 g) , filtered and concentrated on a rotary evaporator. By means of flash chromatography (Si0 2 60F / ethyl acetate / hexane 1:4) pure title compound A2 is obtained from the residue as a colourless oil (17.45 g, 92.6 %) : ' ' H-NMR (400 MHz, CDCI3, S) : 1.26 (d, 6H) , 1.35 (m, 3H) , 2.15 (m, 2H) , 3.22 (m, 1H) , 3.38 (s, 3H) , 3.60 (m, 2H) , 3.90 (s, 3H) , 4.17 ( , 2H) , 4.28 (m, 2H) , 6.85 - 7.0 (m, 3H) , 7.49 (s, 1H) ppm. Example A3 : Preparation of A solution of 37.0 g A2 in 410 ml toluene is cooled to - 20°C, and 229 ml diisobutyl aluminium hydride solution (1.2 M in toluene) is added over a period of 20 minutes. The reaction mixture is stirred for 1 hour at -20°C, before 220 ml methanol is slowly added. Then 1.5 1 IN HCl is added to the mixture and this is then extracted with t-butyl methyl ether (3 x 1 1). The organic phases are washed consecutively with 1.2 1 water and 1.2 1 brine. The combined organic phases are dried over magnesium sulfate, filtered and concentrated on a rotary evaporator. By means of molecular distillation, title compound A3 is obtained from the residue as a colourless oil (29.7 g, 91.8 %) : ^-NMR (400 MHz, DMSO- d 6 , δ) : 1.08 (d, 6H) , 1.93 (m, 2H) , 3.02 (m, 1H) , 3.28 (s, 3H) , 3.50 (m, 2H) , 3.85 (s, 3H) , 4.02 (m, 2H) , 4.10 (d, 2H) , 4.77 (bs, 1H) , 6.39 (s, 1H) , 6.78 (m, 2H) , 6.93 (m, 1H) ppm. Example A4 : Preparation of In a flask with a magnetic stirrer, 1.2 mg (0.0026 mmol) [Rh (norbornadiene) Cl] 2 and 3.83 mg (0.0054 mmol) (R) - (4, 4' ,5, 5" ,6, 6'-hexamethoxybiphenyl-2, 2 ' -diyl)bis (diphenyl- phosphine) are placed under an atmosphere of argon through repeated evacuation and purging with argon. Then 10 ml degassed toluene is added and stirred for 15 minutes, before 3.75 g (0.01275 mol) A3 and 20 ml degassed toluene are introduced into a 50 ml flask fitted with a stopcock and flushed with argon. With gentle heating, agitation is continued until a homogeneous solution is formed. The catalyst and substrate solutions are forced under pressure via a steel capillary tube into a 50 ml steel autoclave under cover of argon. In 3 purge cycles (argon 20 bar / hydrogen 20 bar) the hydrogen pressure is eventually increased to 1000 bar. The autoclave is heated to 30°C and hydrogenation started by switching on the stirrer. The reaction can take place via hydrogen consumption (fall of pressure in the reservoir of hydrogen) . After a reaction time of 18 hours, the reaction mixture is concentrated, and crude title compound A4 is obtained as a slightly yellowish oil (3.75 g, quantitative): The enantiomeric purity of the product (measured by HPLC: column Chiralcel ODH 0.46x25 cm; hexane/iPrOH: 95/5; temperature: 20 °C; flow rate: 0.6 ml/min; S-product: 22.9 min; R-product: 25.3 min; educt : 27.8 min; UV: 210 nm) amounts to > 95% ee (R) . X H-NMR (400 MHz, CDC1 3 , δ) : 0.96 (m, 6H) , 1.2 (m, 1H) , 1.67 (m, 1H) , 1.90 (m, 1H) , 2.12 (m, 2H) , 2.48 (m, 1H) , 2.68 (m, 1H) , 3.40 (s, 3H) , 3.60 (m, 4H) , 3.89 (s, 3H) , 4.12 (m, 2H) , 6.70 - 6.85 (m, 3H) ppm. Example A5: Preparation of A4 The procedure is analogous to that described under Example 1, but the ligand ( (R) - (6, 6 ' -dimethoxybiphenyl-2, 2 ' -diyl) - bis (dicyclobutylphosphine) ) is used for the catalyst. The reaction is stopped after 18 hours. The conversion amounts to 100%, and enantiomeric purity is 96.3% (R) .

Claims: What is claimed is 1. A process for the preparation of compounds of formula I, wherein Ri and R 2 are, independently of one another, H, C α - C 6 alkyl , Cι-C 6 halogenalkyl , Cι-C 6 alkoxy, Cι-C 6 alkoxy-Cι-C 6 alkyl , or Ci-Cealko y-Ci-Cealkyloxy, and R 3 is Cι-C 6 alkyl comprising a) the reaction of a compound of formula II wherein Ri and R 2 are as defined hereinbefore, with compound of formula III, (III) .COOR, Ra wherein R 3 is as defined hereinbefore, to form a compound of formula IV, wherein R is Cι-Cι 2 alkyl, C 3 -C 8 cycloalkyl, phenyl or benzyl, b) the isolation of the crystalline compound of formula IV, the conversion of the OH group to a leaving group, and the reaction of a compound containing a leaving group in the presence of a strong base to form a compound of formula V, c) the reduction of the carbonic esters of formula V to form the alcohol of formula VI, d) the hydrogenation of the alcohol of formula VI in the presence of hydrogen and catalytic quantities of a metal complex as asymmetric hydrogenation catalyst, comprising metals from the group of ruthenium, rhodium and iridium, to which the chiral bidentate ligands are bonded, to form a compound of formula I. 2. A process according to claim 1, comprising Ri as methoxy- Cι-C 4 alkyloxy or ethoxy-Cι-Calkyloxy and R 2 as methoxy or ethoxy. 3. A process according to claim 2, comprising R Ύ as l-methoxyprop-3-yloxy and R 2 as methoxy. 4. A process according to claim 1, comprising R 3 as a linear or branched Cι-Calkyl. 5. A process according to claim 4, comprising R 3 as isopropyl . 6. A process according to claim 1, comprising R α as 1- methoxy-n-propyloxy, R 2 as methoxy, and R 3 as isopropyl. 7. A process according to claim 1, comprising the processing of step a) at low temperatures in the presence of a secondary lithium amide. 8. A process according to claim 1, comprising in step b) first acylation of the hydroxyl group and then elimination at low temperatures in the presence of an alkali metal alcoholate in the reaction mixture of the acylation process. 9. A process according to claim 1, comprising step c) being carried out at low temperatures in the presence of metal hydrides as reduction agents. 10. A process according to claim 1, comprising step d) being carried out in the presence of metal complexes of formula VII or Vila as hydrogenation catalysts, [LMeYZ] (VII), [LMeY]Ε ~ (Vila) / wherein Me is rhodium; Y stands for two olefins or one diene; Z is Cl, Br or I; E ~ is the anion of an oxygen acid or a complex acid; and L is a chiral ligand from the ditertiary diphosphine group, in which the phosphine groups are bonded to a C 2 -C 4 chain of the diphosphine backbone chain, and the diphosphine forms a five to seven-member ring together with the rhodium atom. 11. A process according to claim 10, comprising L as formula VIII, wherein m and n in each case are 0 or an integer from 1 to 4, and R 8 and R 9 are hydrogen or the same or different substituents, selected from the Cι-Calkyl and Cι-Calkoxy group; and Xi and X 2 are, independently of one another, secondary phosphino . 12. A process according to claim 11, comprising the bonding of substituents in the 6 position or the 6,6' positions. 13. A process according to claims 11 and 12, comprising R 8 and R 9 as methyl, ethyl, methoxy or ethoxy. 14. A process according to claim 11, comprising the X τ and X 2 groups being the same or different and corresponding to formula -PRι 0 Rn, wherein R i0 and Rn are the same or different and are branched C 3 -C 8 alkyl, C 3 -C 8 cycloalkyl, or unsubstituted phenyl or phenyl substituted with one to three Cι-C 4 alkyl, Cι-Calkoxy, or -CF 3 . 15. A process according to claim 11, comprising in formulae VIII n as 0, and Xi and X 2 as a PRioRn group, wherein Rio and Ru in each case are cyclopbutyl, cyclopentyl, cyclohexyl, phenyl or phenyl substituted with 1 or 2 methyl, methoxy or CF 3 . 16. A process according to claim 1, comprising step d) being carried out at temperatures of -20 to 150°C. 17. A process according to claim 1, comprising step d) being carried out under positive pressure. 18. A process according to claim 1, comprising pressure conditions at 10 5 to 2xl0 7 Pa (Pascal) . 19. Compounds of formula VI, wherein Ri and R 2 are, independently of one another, H, Ci- C 6 alkyl , Cι-C 6 halogenalkyl, Cι-C 6 alkoxy, Cι-C 6 alkoxy~Cι-C 6 alkyl , or Cι-C 6 alkoxy-Cι-C 3 alkyloxy, and R 3 is Cι-C 6 alkyl . 20 . Compounds according to claim 19, comprising Ri as methoxy-Cι-C alkyloxy or ethoxy~Cι-C 4 alkyloxy and R 2 as methoxy or ethoxy, and R 3 as Cι-C alkyl . 21 . Compounds according to claim 19 , comprising R α as 1- methoxy-n-propyloxy and R 2 as methoxy, and R 3 as isopropyl . 22 . Compounds of formula IV, wherein Ri and R 2 are, independently of one another, H, Cι~ C 6 alkyl, Cι-C 6 halogenalkyl, Cι-C 6 alkoxy, Cι-C 6 alkoxy-C ι -C 6 alkyl, or Cι-C 6 alkoxy-Cι-C 6 alkyloxy, and R 3 is Cι-C 6 alkyl, and R 7 is Cι-Cι 2 alkyl, C 3 -C 8 cycloalkyl , phenyl or benzyl . 23. Compounds according to claim 19, comprising R x as methoxy-Cι-C 4 alkyloxy or ethoxy-Cι-C 4 alkyloxy and R 2 as methoxy or ethoxy, R 3 as Cι-C 4 alkyl, and R 7 as Cι-C alkyl. 24. Compounds according to claim 19, comprising Ri as 1- methoxy-n-propyloxy and R 2 as methoxy, R 3 as isopropyl, and R as methyl or ethyl .

Inventors: HEROLD PETER, SPINDLER FELIX, STUTZ STEFAN, HEROLD, PETER, SPINDLER, FELIX, STUTZ, STEFAN
Applicants: HEROLD PETER, SPEEDEL PHARMA AG, SPINDLER FELIX, STUTZ STEFAN, HEROLD, PETER, SPINDLER, FELIX, STUTZ, STEFAN
Application year: 2001
Main classification: C07B53
IPC codes: C07B61, C07C29, C07C41, C07C43, C07C69