NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS

Abstract: The invention provides 1,3,4-thiadiazoles and 1,3,4-oxadiazoles having the following formula (I):in which, Y is S or O,R1 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, aryl, heteroaryl or a polycyclic group, optionally substituted,R2 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl or aryl optionally substituted,R3 is X2-R'3, in which X2 is a binding group and R'3 is cycloalkyl, heterocycloalkyl, cycloalkenyl, aryl, heteroaryl, or a polycyclic group; optionally substituted,or their pharmaceutically acceptable derivatives,the process for their preparation and their use for the manufacture of a medicament for the treatment of disorders for which a treatment by a PDE7 inhibitor is relevant.

Description: NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS • Field of the invention. The invention relates to novel thiadiazoles and oxadiazoles, processes for their preparation, and their use as phosphodiesterase 7 (PDE7) inhibitors. Background of the invention. Phosphodiesterases (PDE) play an important role in various biological processes by hydrolysing the key second messengers adenosine and , guanosine 3 ',5' -cyclic monophosphates (cAMP and cGMP respectively) into their corresponding 5 ' -monophosphate nucleotides. Therefore, inhibition of PDE activity produces an increase of cAMP and cGMP intracellular levels that activate specific protein phosphorylation pathways involved in a variety of functional responses . At least eleven isoenzymes of mammalian cyclic nucleotide phosphodiesterases, numbered PDE 1 through PDE 11, have been identified on the basis of primary structure, substrate specificity or sensitivity to cofactors or inhibitory drugs . ; - - - Among these phosphodiesterases, PDE7 is a cAMP-specific PDE. The biochemical and pharmacological characterisation showed a high-affinity cAP-specific PDE (Km=0.2 μM) , that was not affected by cGMP potent selective PDE isoenzyme inhibitors . PDE7 activity or protein has been detected in T-cell lines, B-cell lines, airway epithelial (AE) cell lines and several foetal tissues . Increasing cAMP levels by selective PDE7 inhibition appears to be a potentially promising approach to specifically block T-cell mediated immune responses. Further studies have demonstrated that elevation of intracellular cAMP levels can modulate inflammatory and immunological processes. This selective approach could presumably be devoid of the side effects associated with known selective inhibitors (e.g. PDE3 or PDE4 selective inhibitors) and which limit their use. A functional role of PDE7 in T-cell activation has also been disclosed; therefore selective PDE7 inhibitors would be candidates for the treatment of T-cell-related diseases. AE cells actively participate in inflammatory airway diseases by liberating mediators such as arachidonate metabolites and cytokines. Selective inhibition of PDE7 may be a useful anti-inflammatory approach for treating AE cells related diseases. Thus, there is a need for selective PDE7 inhibitors, which are active at very low concentrations, i.e. micromolar inhibibitor, preferably nanomolar inhibitors. Summary of the invention. The invention provides pharmaceutical compositions comprising a compound having the following formula (I) : wherein: - Y is O or S; - Rl is: Ci-Cio alkyl, C 2 -Cιo alkenyl, C 2 -C 10 alkynyl, cycloalkyl , cycloalkenyl , heterocycle, aryl , or a polycyclic group; each optionally substituted with one or several groups Xι-R, identical or different, in which: - Xi is : a single bond, lower alkylene, C 2 -C 5 alkenylene, cycloalkylene, arylene or divalent heterocycle, and, - R 4 is : 1) H, =0, N0 2 , CN, halogen, lower haloalkyl, lower alkyl, carboxylic acid bioisostere, -2) C00R 5 , C(=0)R 5 , C(=S)R 5 S0 2 R 5 , SOR 5 , SO 3 R 5 , SR 5 , 0R 5 , 3) C(=0)NR 7 R 8 , C(=S)NR 7 R 8 , C (=N-CN) NR 7 R 8 , C(=N- S0 2 NH 2 )NR 7 R 8 , C(=CH-N0 2 )NR 7 R 8 , C(=NR 7 )NHR 8 , C(=NR 7 )R 8 , C(=NR 9 )NHR 8 , C(=NR 9 )R 8 , S0 2 NR 7 R 8 or NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , SO2R5, C(=NR 9 )NHRιo, C(=NR 9 )Rιo, C (=CH-NO 2 )NR 9 Rι 0 , C(=N-S0 2 NH 2 )NR 9 Rιo, C (=N-CN) NR 9 Rι 0 or C(=S)NR 9 R 10 ; R2 is: lower alkyl, C 2 -C 10 alkenyl, I C 2 -Cιo alkynyl, cycloalkyl , cycloalkenyl , heterocycle, aryl ; each optionally substituted with one or several groups which are the same or different and which are selected from: 1) H, carboxylic acid bioisostere, lower haloalkyl, halogen, 2) COOR5, 0R 5 , S0 2 R 5 , 3) S0 2 NRnRi2, C(=0)NR 11 Ri 2 or NRnRι 2 in which R and R 12 are the same or different and are selected from OH, R 5 , R s , C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 Rιo, C (=CH-N0 2 ) NR 9 Rι 0 , C (=N-CN) NR 9 R 10 , C(=N- S0 2 NH 2 )NR 9 Rιo, C(=NR 9 )NHRι 0 or C(=NR 9 )Rιo; R3 is X 2 -R' 3 wherein: - X 2 is a single bond or, a group selected from C 1 -C 4 alkylene, C 2 -C 6 alkenylene, C -C 6 alkynylene, each optionally substituted with one or several groups which are the same or different and which are selected from: 1) H, C 1 -C 3 alkyl, C 3 -C 4 cycloalkyl, aryl, heterocycle, =0, CN, 2) OR 5 , =NR 5 or, 3) NR 13 R 14 in which R i3 and R 14 are the same or different and are selected from R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 R 10 , C(=CH-NO 2 )NR 9 R 10 , C(=NR 9 )NHRιo or C(=NR 9 )R 10 ; - R'3 is: cycloalkyl, cycloalkenyl , aryl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -Rι 7 , identical or different, in which: - X 3 is : a single bond, lower alkylene, C 2 -C 6 alkenylene, C 2 -C 6 alkynylene, cycloalkylene, arylene, divalent heterocycle or a divalent polycyclic group, and, - R 17 is : 1) H, =0, N0 , CN, lower haloalkyl, halogen, carboxylic acid bioisostere, cycloalkyl, 2) COOR 5 , C(=0)R 5 , C(=S)R 5 , S0 R 5 , SOR 5 , SO 3 R 5 , SR 5 , 0R 5 , S0 2 NH 2 )NRι 5 i6, C(=CH-N0 2 )NR 15 Rι 6 , S0 2 NR 15 Rι 6 , C(=NR 15 )NHR 16 , C(=NR 15 )Ri S , C (=NR 9 ) NHRι 6 , > C(=NR 9 )Rι 6 or NR 15 Ri 6 in which R 15 and R 16 are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 R 10 , C(=CH- NO 2 )NR 9 R 10 , C(=N-CN)NR 9 Rιo, C (=N-S0 2 NH 2 ) NRgRio, C(=NR 9 )NHR 10 or C(=NR 9 )Rι 0 , 4) heterocycle opti ronally substituted with one or several groups R 5 ; wherein, R5 and Rs are the same or different and are selected from : - H, - lower alkyl, C 2 -C6 alkenyl, C 2 -C 6 alkynyl; - X 4 -cycloalkyl, X 4 -cycloalkenyl, X 4 -aryl, X -heterocycle or X-polycyclic group, in which X 4 is a single bond, lower alkylene or C 2 -C 6 alkenylene; each optionally substituted with one or several groups which are the same or different and which are selected from: - halogen, =0, COOR 2 o# CN, OR 20 , lower alkyl optionally substituted with OR 2 o, O-lower alkyl optionally sustituted with OR20, C(=0) -lower alkyl, lower haloalkyl, X 5 -N-Rι 8 in which X 5 is a single ig bond or lower alkylene and R 18 , R 19 and R 2 o are the same or different and are selected from H or lower alkyl ; Xβ-heterocycle, Xβ-aryl, Xβ-cycloalkyl, Xε- cycloalkenyl, X 6 -polycyclic group in which Xβ- .is selected from a single bond or lower alkylene, these groups being optionally substituted with one or several groups, identical or different, selected from halogens, COOR21, OR 2 ι,or (CH 2 ) n NR 2 iR22 in which n is 0, 1 or 2 and R 21 and R 22 are the same or different and are selected from H or lower alkyl; R 9 is selected from H, CN, OH, lower alkyl, O-lower alkyl, aryl, heterocycle, S0 2 NH 2 or X 5 -N-Rι 8 in which X 5 is a R19 single bond or lower alkylene and R 18 and Rχ 9 are the same or different and are selected from H or lower alkyl; Rio is selected from hydrogen, lower alkyl, cyclopropyl or heterocycle; or a pharmaceutically acceptable derivative thereof, together with a pharmaceutically acceptable carrier, with the proviso that the compound of formula (I) is not 4- [2-Formylimino-5- (4-methoxy-phenyl) - [1,3,4] thiadiazol-3-yl] - butyric acid ethyl ester, 4- [5- (4-Chloro-phenyl) -2-formylimino- [1,3,4] thiadiazol-3-yl] - butyric acid ethyl ester. The invention also relates to novel compounds having the following formula (I) above. These compounds are selective PDE7 inhibitors. They can be used in the treatment of various diseases, such as T-cell- related diseases, autoimmune diseases, inflammatory diseases, respiratory diseases, central nervous system (CNS) diseases, allergic diseases, endocrine or exocrine pancreas diseases, gastrointestinal diseases, visceral pain, inflammatory bowel disease, osteoarthritis, multiple sclerosis, chronic obstructive pulmonary disease (COPD) , asthma, cancer, acquired immune deficiency syndrome (AIDS) or graft rejection. The invention also relates to a process 'for preparing the above compounds. The invention further concerns the use of a compound of formula (I) for the preparation of a medicament for '..the prevention or the treatment of disorders for which therapy by a PDE7 inhibitor is relevant. The invention also provides a method for the treatment of a disorder for which therapy by a PDE7 inhibitor is relevant, comprising administering to a mammal in need thereof an effective amount of compound of formula (I) . The invention also concerns a pharmaceutical composition comprising a compound of formula (I) together with a pharmaceutically acceptable carrier. 1 The invention also relates to a pharmaceutical composition for the treatment of a disorder for which therapy by a PDE7 inhibitor is relevant, comprising a compound of formula (I) together with a pharmaceutically acceptable carrier. Detailed description of the invention. The present invention provides pharmaceutical compositions comprising compounds having formula I, in which Rl, R2, R3 and Y are as defined above with the exclusion of the compounds recited above. In the following and in the foregoing text: aryl is understood to ' refer to an unsaturated carbocycle, exclusively comprising carbon atoms in the cyclic structure, the number of which is between 5 and 10, including phenyl, naphthyl or tetrahydronaphthyl; - heterocycle is understood to refer to a non-saturated or saturated monocycle containing between 1 and 7 carbon atoms in the cyclio structure and at least one heteroatom in the cyclic structure, such as nitrogen, oxygen, or sulfur, preferably from 1 to 4 heteroatoms, identical or different, selected from nitrogen, sulfur and oxygen atoms. Suitable heterocycles include morpholinyl, piperazinyl, pyrrolidinyl, piperidinyl, pyrimidinyl, 2- and 3-furanyl, 2- and 3-thienyl, 2-pyridyl, 2- and 3-pyranyl, hydroxypyridyl , pyrazolyl, isoxazolyl, tetrazole, imidazole, triazole and the like; polycyclic groups include at least two cycles, identical or different, selected from aryl, heterocycle, cycloalkyl, cycloalkenyl groups fused together to form said polycyclic group such as 2- and 3-benzothienyl , 2- and 3- benzofuranyl , 2-indolyl, 2-. and 3-quinolinyl, acridinyl, quinazolinyl, indolyl be zo [1, 3] dioxolyl and 9-thioxantanyl; Preferred polycyclic groups include 2 or 3 cycles as defined above . More preferred polycyclic groups include 2 cycles (bicyclic substituents) as defined above. - bicyclic groups refer to two cycles, which are the same or different and which are chosen from aryl, heterocycle, cycloalkyl or cycloalkenyl, fused together to form said bicyclic groups; - halogen is understood to refer to fluorine, chlorine, bromine or iodine; - lower alkyl is understood to mean that the alkyl is linear or branched and contains 1 to 6 carbon atoms; Examples of lower alkyl groups include methyl, ethyl, propyl, butyl, isopropyl, tert-butyl, isobutyl, n-butyl, pentyl, hexyl and the like. - alkenyl is understood to refer to a linear or branched unsaturated carbon atom chain, comprising one or several double bonds, preferably one or two double bonds. Preferred alkenyls comprise from 3 to 6 carbon atoms and one double bonds . - alkynyl is understood to refer to a linear or branched unsaturated carbon atom chain, comprising one or several triple bonds, preferably one or two triple bonds. Preferred alkynyls comprise from 3 to 6 carbon atoms and one triple bonds . - lower haloalkyl are understood to refer to a lower alkyl substituted with one or several halogens; Preferred lower haloalkyl groups include perhaloalkyl groups such as CF 3 . cycloalkyl is understood to refer to saturated monocarbocyle containing from 3 to 10 carbon atoms; preferred cycloalkyl groups comprise cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl . - cycloalkenyl is understood to refer to unsaturated monocarbocyle containing from 3 to 10 carbon atoms. Preferred cyloalkenyl groups contain 1 or 2 double bonds . Examples of suitable cycloalkenyl " are 3-cyclohexene, 3-cycloheptene or the like. - carboxylic acid bioisostere has the classical meaning; common carboxylic acid bioisostere are tetrazol, hydroxamic acid, isoxazole, hydroxythiadiazole, sulfonamide, sulfonylcarboxamide, phosphonates, phosphonamides, phosphinates, sulfonates, acyl sulfonamide, mercaptoazole, acyl cyanamides. Preferred pharmaceutical composition are those containing a compound of formula (I) in which Rl, R2, R3 and Y are as defined above, with the proviso that when Rl is C(=0)-H, then R2 does not represent (CH 2 ) 3-C (=0)OCH 2 CH 3 . The present invention also relates to compounds of formula (I), in which - Y is O or S; - Rl is: C 4 -C 10 alkyl, C 2 -Cιo alkenyl, C 2 -Cιo alkynyl, cycloalkyl , cycloalkenyl , heterocycle, aryl, or a bicyclic group; each optionally substituted with one or several groups X1-R4, identical or different, in which: - Xx is: a single bond, lower alkylene, C 2 -C 6 alkenylene, cycloalkylene, arylene or divalent heterocycle, and, R 4 is : 1) H, =0, N0 2 , CN, halogen, lower haloalkyl, lower alkyl, carboxylic ,acid bioisostere, 2) COOR5, C(=0)R 5 , C(=S)R 5 , S0 2 R 5 , SOR 5 , SO3R5, SR Ξ , OR 5 ", 3) C(=0)NR 7 R 8 , C(=S)NR 7 R 8 , C (=CH-N0 ) NR 7 R 8 , C(=N- CN)NR 7 R 8 , C(=N-S0 2 NH 2 )NR 7 R 8 , C(=NR 7 )NHR 8 , C(=NR 7 )R 8 , C(=NR 9 )NHR 8 , C(=NR 9 )R 8 , S0 2 NR 7 R 8 or NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 S0 2 R 5 , C(=NR 9 )NHRi 0 , C(=NR 9 )R 10 , C (=CH-NO 2 )NR 9 Rι 0 , C(=N-SO 2 NH 2 )NR 9 Ri 0 , C (=N-CN) NR 9 R 10 or C(=S)NR 9 R 10 ; - R2 is: lower alkyl, C 2 -Cιo alkenyl, C 4 -C 10 alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl ; each optionally substituted with one or several groups which are the same or different and which are selected from: 1) H, carboxylic acid bioisostere, lower haloalkyl, halogen, 1 2) COOR 5 , OR 5 , S0 2 R 5 , 3) SO 2 NR 11 R 12 , C(=0)NRnRi2 or NRnRι 2 in which Rn and R 12 are the same or different and are selected C(=S)NR 9 Ri 0 , C(=CH-N0 2 )NR 9 Rio, C (=N-CN) NR 9 Rι 0 , C(=N- SO 2 NH 2 )NR 9 Ri 0 , C(=NR 9 )NHRιo or C(=NR 9 )Rι 0 ; R3 is X -R'3 wherein: - X 2 is a single bond or, a group selected from C 1 -C 4 alkylene, C 2 -C 6 alkenylene, C 2 -C 6 alkynylene, each optionally " substituted with one or several groups which are the same or different and which are selected from: 1) H, C 1 -C 3 alkyl, C 3 -C4 cycloalkyl, aryl, heterocycle, =0, CN, 2) 0R 5 , =NR 5 or, 3) NRι 3 R 14 in which R 13 and Rχ are the same or different and are selected from R 5 , Re, C(=0)NR Ξ R 6 , C(=0)R 5 , SO 2 R5, C(=S)NR 9 R 10 , C(=CH-NO 2 )NR 9 R 10 , C(=NR 9 )NHRιo or C(=NR 9 )Rι 0 ; - R'3 is: cycloalkyl , cycloalkenyl, aryl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 ~Rι , identical or different, in which: - X 3 is : a single bond, low.er alkylene, C 2 -C 6 alkenylene, C 2 -C 6 alkynylene, cycloalkylene, arylene, divalent heterocycle or a divalent polycyclic group, and, - R 17 is : 1) H, =0, NO 2 , CN, lower haloalkyl, halogen, cycloalkyl , 2) COOR 5 , C(=0)R 5 , C(=S)R 5 , S0 2 R 5 , SOR 5 , SO 3 R 5 , SR 5 , OR 5 , 3) C (=N-CN) NR15R16, C(=N- S0 2 NH2)NRι 5 Ri6, C(=CH-N0 2 )NRι 5 Rι 6 , S0 2 NRi5R 16 , C(=NRi 5 )NHRi 6 , C(=NR 15 )R 16 , C (=NR 9 )NHRι 6 , C(=NR 9 )Rι S or NR 15 R 1S in which R 15 and ι e are the same or different and are selected from OH, R 5 , Rs, C(=0)NR 5 R 6 , C(=0)R 5 , SO 2 R 5 , C(=S)NR 9 Rιo, C(=CH- N0 2 )NR 9 Rιo, C(=N-CN)NR 9 R 10 , C (=N-S0 2 NH 2 ) NR 9 Rιo, C(=NR 9 )NHRιo or C(=NR 9 )Rι 0 ; . 4) heterocycle optionally substituted with one or several groups R 5 ; wherein, R 5 , Rς , R 9 and Rχ 0 are as defined above, with the proviso that, - when Rl is phenyl, it bears at least one substituent other than H, - when X 2 is a single bond and both Rl and R' 3 are phenyl, each of Rl and R' 3 bear at least one substituent other than H, - when X 2 is a single bond and R' 3 is phenyl, R'3 is not substituted by an ester or a carboxylic acid in the ortho position, - the atom of R3 which is linked to the thiadiazole group is a carbon atom, with the exclusion of the following compounds, 1-Phenyl-1- [4-phenyl-5- (5-trifluoromethyl-2H- [1,2,4] triazol- 3-ylimino) -4, 5-dihydro- [1, 3, 4] thiadiazol-2-yl] -methanone, 1- [4-Phenyl-5- (5-trifluoromethyl-2iϊ- [1,2, 4] triazol-3- ylimino) -4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -l-thiophen-2-yl- methanone, 1-Phenyl-1- (4-phenyl-5-p-tolylimino-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -methanone, Cyclohexyl- [3- (2,4, 6-trichloro-phenyl) -5- (2, 3, 3-trimethyl- cyclopent-1-enylmethyl) -3H- [1, 3 ,4] thiadiazol-2-ylidene] - a ine, 2- (3, 5-Diphenyl-3H- [1,3,4] thiadiazol-2-ylideneamino) -1,4- diphenyl-but-2-ene-l,4-dione, 2- [3-Phenyl-5- (1-phenyl-methanoyl) -3H- [1, 3,4] thiadiazol-2- ylideneamino] -but-2-enedioic acid dimethyl ester, 2- [5- (1-Phenyl-methanoyl) -3-p-tolyl-3ff- [1,3,4] thiadiazol-2- ylideneamino] -but-2-enedioic acid dimethyl ester, and, 2- [3- (4-Chioro-phenyl) -5- (1-phenyl-methanoyl) -3H- [1, 3,4] thiadiazol-2-ylideneamino] -but-2-enedioic acid dimethyl ester. Preferred compounds of formula (I) are those in which Rl, R2, R3 and Y are as defined above, with the proviso that, when R2 is a phenyl, unsubstituted or substituted whit 1 to 3 chorine or with a methyl, then R3 does not represent C(=0)- phenyl, C (=0) -thienyl, phenyl or CH 2 - (2, 3 , 3-trimethyl- cyclopent-1-enyl) . Other preferred compounds of formula (I) are those in which - Rl is: C 4 -C 6 alkyl, cycloalkyl, cycloalkenyl, heterocycle, aryl, or a bicyclic group; each optionally substituted with one or several groups Xι-R , identical or different, in which: - Xi is a single bond, a divalent heterocycle or a lower alkylene, and, - R 4 is selected from: 1) H, =0, halogen, CN, lower haloalkyl, preferably CF 3 , lower alkyl, carboxylic acid bioisostere, 2) COOR5, SO2R5, 0R 5 , C(=0)R 5 3) C(=0)NR 7 R 8 , S0NR 7 R 8 or NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C (=NR 9 ) NHRio, C(=NR 9 )Rιo or C(=S)NR 9 Rι 0 . Other preferred compounds of formula (I) are those in which R2 is lower alkyl . Further preferred compounds of formula (I) are those in which R3 is X -R' 3 wherein, - X 2 is a single bond, C1-C4 alkylene, C 2 -C 6 alkenylene or C 2 -C 6 alkynylene and, - R'3 is: cycloalkyl, cycloalkenyl , aryl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -Rι 7 , identical or different, in which: - X 3 is a single bond or lower alkylene, and, - R 17 is: 1) H, =0, N0 2 , CN, lower haloalkyl, halogen, cycloalkyl, 2) C00R 5 , C(=0)R 5 , C(=S)R 5 , S0 2 R 5 , S0R 5 , SO 3 R 5 , SR 5 , 0R 5 , 3) C(=0)NR 15 R 16 , C(=S)NR 15 Rιs, C (=N-CN) NRι 5 Rι 5 , C(=CH-N0 2 )NR 15 Rιs, S0 2 NRι 5 Rι 6 , C (=NRι 5 ) NHR 16 , C(=NR 15 )Rιs, C(=NR 9 )NHRi6, C(=NR 9 )R 16 or NRι 5 Rι 6 in which R 15 and Riε are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 Rιo, C(=CH-NO 2 )NR 9 R 10 , C (=N-CN) NR 9 Rι 0 , C(=NR 9 )NHRιo or C(=NR 9 )Rι 0/ 4) heterocycle optionally substituted with one or several groups R 5 . Particularly preferred compounds of formula (I) are those in which Rl is: cycloalkyl, preferably cyclohexane, cycloalkenyl , aryl, preferably phenyl, or a bicyclic group; each optionally substituted with one or several groups Xι-R 4/ identical or different, in which: - Xi is a single bond or a divalent heterocycle, and, - R is selected from: 1) H, halogen, CF 3 , =0, 2) COOR 5 , 0R 5 , 3) C(=0)NR 5 R 6 . Other particularly preferred compounds of formula (I) are those in which R2 is CH 3 . Further particularly preferred compounds of formula (I) are those in which R3 is X 2 -R' 3 wherein, - X is a single bond, C 1 -C 4 alkylene or C 2 -C 6 a1keny1ene , and, - R'3 is: cycloalkyl, aryl, preferably phenyl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -R 17 , identical or different, in which: - X 3 is a single bond or -CH 2 -, and, - R 17 is : 1) H, CN, CF 3 , halogen, N0 2 , 2) COOR 5 , S0R 5 / OR 5 , C(=0)R 5 , 3) C(=0)NR 15 Rι 6 , S0 2 NR 15 Rι 6 or NR 15 Rι 6 in which R 15 and Ri 6 are the same or different and are selected from OH, R 5 , R e , C(=0)NR 5 R e , C(=0)R 5 , SO 2 R 5 , C(=S)NR 9 Rιo, C(=CH-N0 2 )NR 9 Rιo, C (=NR 9 )NHRι 0 , C(=NR 9 )Rιo or C(=N-CN)NR 9 Rιo, 4) heterocycle optionally substituted with one or several groups R 5 . More preferred compounds- of formula (I) are those in which - Rl is: C 4 -C 6 alkyl cycloalkyl , cycloalkenyl , heterocycle, aryl, or a bicyclic group; each optionally substituted with one or several' groups Xχ-R 4 , identical or different, in which: - Xi is a single bond a divalent heterocycle or a lower alkylene, and, - R 4 is selected from: 1) H, =0, halogen, CN, lower haloalkyl, preferably CF 3 , lower alkyl, carboxylic acid bioisostere, 2) COOR 5 , SO 2 R 5 , 0R 5 , C(=0)R 5 3) C(=0)NR 7 R 8 , S0 2 NR 7 R 8 or NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from R 5 , Re, C(=0)NR 5 Re, C(=0)R 5 , S0 2 R 5 , C (=NR 9 )NHRι 0 , C(=NR 9 )R 10 or C(=S)NR 9 Rι 0 , R2 is lower alkyl, and, R3 is X2~R' 3 wherein, - X 2 is a single bond, Cι-C 4 alkylene, C -C 6 alkenylene or C2-C6 alkynylene and, - R'3 is: cycloalkyl , cycloalkenyl, aryl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 ~Rχ , identical or different, in which: - X 3 is a single bond or lower alkylene, and, ' - Rχ 7 is: 1) H, =0, N0 , CN, lower haloalkyl, halogen, cycloalkyl , 2) C00R 5 , C(=0)R 5 , C(=S)R 5 , S0 2 R 5 , SOR5, SO3R5, SR 5 , 0R 5 , 3) C(=0)NRι 5 Rχe, C(=S)NRχ 5 Ri6, C (=N-CN)NRχ 5 Rχ6, C(=NRχ 5 )R 16 , C(=NR 9 )NHRχ 6 , C(=NR 9 )R 16 or NRχ 5 Rχ6 in which Rχ 5 and Rχ 6 are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , SO 2 R5, C(=S)NR 9 R 10 , C(=CH-NO 2 )NR 9 R 10/ C (=N-CN) NR 9 R 10 , C(=NR 9 )NHR 10 or C(=NR 9 )R 10 , 4) heterocycle optionally substituted with one or several groups R 5 . Other more preferred compounds of formula (I) are those in which, Rl is: cycloalkyl, preferably cyclohexane, cycloalkenyl , aryl, ' preferably phenyl, or a bicyclic group; each optionally substituted with one or several groups Xι-R 4 , identical or different, in which: - X x is a single bond or a divalent heterocycle, and, - R 4 is selected from: 1) H, halogen, CF 3 , =0, 2) COOR 5 , 0R 5 , 1 * 7 3) C(=0)NR 5 R 6 , R2 is CH 3 , and, R3 is X 2 -R' 3 wherein, - X 2 is a single bond, Cι-C 4 alkylene or C 2 -C 6 alkenylene, and, - R'3 is: cycloalkyl , aryl, preferably phenyl heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -R 17 , identical or different, in which: - - X 3 is a single bond or -CH 2 -, and, - R 17 is: 1) H, CN, CF 3 , halogen, N0 2 2) COOR5, SO 2 R5, 0R 5 , C(=0)R 5 3) C(=0)NR 15 Rχe, S0 2 NRχ5R 16 or NRχ 5 Rχ6 in which R 15 and Rχ 6 are the same or different and are selected C(=S)NR 9 Rχ 0 , C(=CH-NO 2 )NR 9 Rχ 0 , C (=NR 9 )NHR 10 , C(=NR 9 )Rχo or C(=N-CN)NR 9 R 10 , 4) heterocycle optionally substituted with one. • or several groups R 5 . Other more preferred compounds of formula (I) are those in which, Y is 0, Rl is: cycloalkyl, preferably cyclohexane, cycloalkenyl, aryl, preferably phenyl, or a bicyclic group; each optionally substituted with one or several groups X1-R4, identical or different, in which: - Xx is a single bond or a divalent heterocycle, and, \ R 4 is selected from: 1) H, halogen, CF 3 , =0, 2) COOR5, 0R 5 , 3) C(=0)NR 5 R 6 , R2 is CH 3 , and, R3 is X 2 -R' 3 wherein, - X 2 is a single bond, Cχ-C 4 alkylene or C 2 -C 6 alkenyl ene, and, - R'3 is: cycloalkyl, aryl, preferably phenyl heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -R 17 , identical or different, in which: - X 3 is a single bond or -CH 2 -, and, - Rχ 7 is: 1) H, CN, CF 3 , halogen, N0 2 2) COOR 5 , S0 2 R 5 , 0R 5 , C(=0)R 5 3) C(=0)NRχ 5 Rχ S , S0 2 NRχ 5 Rχ 6 or NR 15 Rχ 6 in which Rχ 5 and Ri 6 are the same or different and are selected from OH, R 5 , R s , C(=0)NR 5 R 6 , C(=0)R 5 , SQ 2 R 5 , C(=S)NR 9 Ri 0 , C (=CH-N0 2 ) NR 9 Rι 0 , C (=NR 9 ) NHR10, C(=NR 9 )Rιo or C(=N-CN)NR 9 Rιo, 4) heterocycle optionally substituted with one or several groups R 5 . More specifically, a group of compounds of formula (I) which has been found to be of particular interest are those in which, Rl is: cyclohexane, phenyl or a bicyclic group; each optionally substituted with one or several groups X1-R4, identical or different, in which: Xi is a single bond or a divalent heterocycle, and, R 4 is selected from: 1) H, halogen, CF 3 , 2) COOH, OH, 3) C(=0)NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from H or lower alkyl, R2 is CH 3 , and, R3 is X 2 -R' 3 wherein, - 2 is a single bond, C1-C4 alkylene or C 2 -C 6 alkenylene, and, - R'3 is: phenyl heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -R 17 , identical or different, in which: - X 3 is a single bond, and, - R 17 is : 1) CN, OH, CF 3 , =0, Cι-C 6 alkoxy, halogen, 2 ) COOR 5 , SO 2 R 5 , 3) C(=0)NRι 5 R 16 , S0 2 NR 15 R 16 or NR15R1S in which R 15 and Rie are the same or different and are selected from OH, C(=0)R 5 , C(=0)NR 5 R 6 , R5 or R 6 , 4) heterocycle optionally substituted with one or several groups R 5 . Most preferred compounds of formula (I) are those in which Y is S. Preferably, in each of the above definition of Rl: R 5 is selected from - H, or, lower alkyl, optionally substituted with OH, preferably CH 3 . R 6 is selected from H, or, lower alkyl,preferably CH 3 . R 9 and R 10 are selected from - H, or, - lower alkyl, preferably CH 3 . Preferably, in each of the above definition of R2 : R 5 and R 6 are selected from H, or, - lower alkyl, preferably CH 3 . - R 9 and R 10 are selected from: H, or, lower alkyl, preferably CH 3 . Preferred compounds are: 11 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzoic acid II.1 (1R*, 2R*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] - cyclohexanecarboxylic acid 11.2 (S) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -2-phenyl-ethanol 11.7 2 -{2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -phenyl} -ethanol 11.9 {1- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclopentyl} - methanol 11.10 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 ,4] thiadiazol- 2-ylideneamino] -cyclohexanecarboxylic acid 12.1 5- [5- (4-Chloro-phenyl) -3-methyl-3H [1, 3 , 4] thiadiazol- 2-ylideneamino] -2-fluoro-benzoic acid 12.2 3- [5- (4-Chloro-phenyl) -3-methyl-3ff- [1, 3 , 4] thiadiazol- 2-ylideneamino] -2, 5, 6-trifluoro-benzoic acid 13 [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene] -propyl-amine 13.1 (S)-2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -butan-1-ol Z \ 13.3 [5- (4-Chloro-phenyl) -3-methyl-3JJ- [1, 3 , 4] thiadiazol- 2-ylidene] -cyclobutyl-amine 13.4 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -azepan-2-one 13.7 [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene] -cyclopentyl-amine 13.8 [5- (4-Chloro-phenyl) -3-methyl-3JΪ- [1, 3 , 4] thiadiazol- 2-ylidene] -cycloheptyl-amine 13.10 (S) -2- [5- (4-Chloro-phenyl) -3-methyl-3JT- [1,3,4] thiadiazol-2-ylideneamino] -3-methyl-butan-1- ol 13.11 2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -2-methyl-propan-l- ol 13.13 tert-Butyl- [5- (4-chloro-phenyl) -3-methyl-3H- [1 , 3 , 4] thiadiazol -2 -ylidene] -amine 13 . 14 [5- (4 -Chloro-phenyl) -3 -methyl-3H- [1 , 3 , 4] thiadiazol - 2 -ylidene] -isopropyl -amine 13 . 15 4- [5 - (4-Chloro-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzoic acid 13.16 [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol- 2-ylidene] - (1-ethyl-propyl) -amine 13.17 4- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -phenol 13.18 N- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexane-1, 2-diamine 13.19 [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol- 2-ylidene] - (4-fluoro-phenyl) -amine 13.20 N- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3,4] thiadiazol-2-ylidene] -cyclohexane-l,4-diamine 13.25 (1R*, 2S*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol 13.26 [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol- 2-ylidene] - (4-trifluoromethyl-phenyl) -amine 14 3- [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzoic acid 15 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -phenol 2,2- 16 5- [5 - (4 -Chloro-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -2-hydroxy-benzoic acid 16.1 (1-Aza-bicyclo [2.2.2] oct-3-yl) - [5- (4-chloro-phenyl) - 3-methyl-3H- [1, 3 , 4] thiadiazol-2-ylidene] -amine 16.3 2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -phenol 16.5 (R) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -butan-1-ol 16.7 [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 ,4] thiadiazol- 2-ylidene] - (3-fluoro-phenyl) -amine 16.8 (3-Chloro-phenyl) - [5- (4-chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine 16.9 {3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -phenyl} -acetic acid 16.11 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzamide 17 Bicyclo [2.2.1] hept-2-yl- [5- (4-chloro-phenyl) -3- methyl-3H- [1, 3 , 4] thiadiazol-2-ylidene] -amine 18 (1R*, 2R*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol 18.1 5- (5-Cyclohexyl-3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino) -2-methoxy-phenol 18.2 3- (5-Cyclohexyl-3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino) -benzoic acid 18.3 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] hiadiazol-2-ylideneamino] -4-hydroxy-benzoic acid 18.4 (5-Cyclohexyl-3-methyl-3H- [1,3,4] thiadiazol-2- ylidene) - (3-methanesulfonyl-phenyl) -amine 19 (1R*, 2R*) -2- [5- (4-Methanesulfonyl-phenyl) -3-methyl- 3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol 110 Cyclohexyl- [5- (2 , 4-dichloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine 110.1 [5- (2-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol- 2-ylidene] -cyclohexyl-amine 111 Cyclohexyl- [3-methyl-5- (4-trifluoromethyl-phenyl) - 3H- [1,3,4] thiadiazol-2-ylidene] -amine 112 Cyclohexyl- (3-methyl-5-pyridin-4-yl-3H- [1,3,4] thiadiazol-2-ylidene) -amine 113 [5- (3-Chloro-phenyl) -3-methyl -3H- [1,3,4] thiadiazol- 2-ylidene]-cyclohexyl-amine 114 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile 115 Cyclohexyl- [5- (4-methanesulfonyl-phenyl) -3-methyl- 3H- [1,3,4] thiadiazol-2-ylidene] -amine 115.1 [3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -dimethyl-amine 115.2 Cyclohexyl- [5- (3-methoxy-4-nitro-phenyl) -3-methyl- 3H- [1,3,4] thiadiazol-2-ylidene] -amine- 116 2,4-Dichloro-5- (5-cyclohexylimino-4-methyl-4 , 5- dihydro- [1, 3,4] thiadiazol-2-yl) -benzenesulfonamide 117 Cyclohexyl- (3-methyl-5-thiophen-3-yl-3H- [1,3,4] thiadiazol-2-ylidene) -amine 117.1 Cyclohexyl- [5- (3 , 5-dichloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine 117.2 Cyclohexyl- [5- (2-ethyl-5-methyl-2H-pyrazol-3-yl) -3- methyl-3H- [1,3, 4] thiadiazol-2-ylidene] -amine 118 [5- (3-Chloro-2, 6-dimethoxy-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2-ylidene] -cyclohexyl-amine ; 118.1 Cyclohexyl- (5-isoxazol-5-yl-3-methyl-3H- [1,3 , 4] thiadiazol-2-ylidene) -amine 118.2 Cyclohexyl- [3-methyl-5- (5-pyridin-2-yl-thiophen-2- yl) -3H- [1,3,4] thiadiazol-2-ylidene] -amine 118.3 5- (5-Cyclohexylimino-4-methyl-4,5- dihydro [1,3,4] thiadiazol-2-yl) -2-methoxy-benzene- 1,3-diol; compound with trifluoro-methanesulfonic acid 118.4 ' 5- (5-Cyclohexylimino-4-methyl-4,5- dihydro [1,3,4] thiadiazol -2-yl) -2 , 3-dimethoxy-phenol ; compound with trifluoro-methanesulfonic acid 118.5 [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol- 2-ylidene] -cyclohexyl-amine 118.6 2-Chloro-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3, 4] " thiadiazol-2-yl) -6-methoxy-phenol; compound with 1, 1, 1-trifluoro-methanesulfonic acid 119 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide 119.1 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N,N-diethyl- benzenesulfonamide ' - - ' 119.2 {5- [4-Chloro-3- (4-methyl-piperazine-1-sulfonyl) - phenyl] -3 -methyl-3H- [1,3,4] thiadiazol-2-ylidene} - cyclohexyl-amine 119.3 2-Chloro-5- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-pyridin-4-ylmethyl- benzenesulfonamide 119.4 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-morpholin-4-yl-ethyl) - benzenesulfonamide 119.5 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-benzenesulfonamide 119.6 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- (2-m rpholin-4-yl- ethyl) -benzenesulfonamide 119.7 2-Chloro-5- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-isopropyl-N- (2-morpholin-4- yl-ethyl) -benzenesulfonamide 119.8 2-Chloro-5- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- [2- (2-methoxy- ethoxy) -ethyl] -benzenesulfonamide . 119 9 C-Chloro- (cyclohexylimino-methy1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (dimethylamino-hydroxy- propyl) -N-ethyl-benzenesulfonamide 119.10 2-Chloro-5- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2 , 3-dihyd oxy-propyl) -N- ethyl-benzenesulfonamide 119.11 2-Chloro-5- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- (2-hydroxy-3- pyrrolidin-1-yl-propyl) -benzenesulfonamide 119 . 12 2 -Chloro-5 - (cyclohexylimino-methyl-4 , 5 -dihydro- [1 , 3 , 4 ] thiadiazol -2 -yl) -N- (2 -diethylamino-ethyl) -N- ethyl -benzenesulfonamide 119 . 14 2 -Chloro-5- (5-cyclohexylimino-4-methyl -4 , 5-dihydro- [1 , 3 , 4 ] thiadiazol -2 -yl) -N- (2 -dimethylamino-propyl) -N- ethyl -benzenesulfonamide 120 [5- (4 -Chloro-phenyl) -2 - cyclohexyl i mi no- [1 , 3 , 4] thiadiazol -3 -yl] -acetic acid methyl ester 121 3- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester 121.1 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid 121.2 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide 121.3 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-hydroxy-ethyl) - benzamide 121.4 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-methyl-benzamide 122 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzene-1, 2-diol 123 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -2, 6-dimethoxy-phenol 123.1 6- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -pyridin-2-ol 123.2 5- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzene-1, 2 , 3-triol 124 2- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -quinolin-8-ol 125 Cyclohexyl- (3-methyl-5-pyrazin-2-yl-3H- [1,3,4] thiadiazol-2-ylidene) -amine 126 5- [ (E) -2- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -vinyl] -2-methoxy-phenol 127 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -2-methoxy-phenol 128 Cyclohexyl- (3-methyl-5-quinolin-8-yl-3H- [1,3,4] thiadiazol-2 -ylidene) -amine 129 [4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1, 3,4] thiadiazol-2-yl) -phenyl] -dimethyl -amine 130 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -benzenesulfonamide 131 [5- (5-Chloro-lH-indol-2-yl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -cyclohexyl -amine; compound with trifluoro-methanesulfonic acid 131.1 2- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1, 3,4] thiadiazol-2 -yl), -phenol; compound with 1,1,1- trifluoro-methanesulfonic acid 132 5- (5-Cyclohexylimino-4-methy1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -2-methoxy-phenol; compound with 1,1, 1-trifluoro-methanesulfonic acid 133 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol-2 -yl) -phenol; compound with 1,1,1- trifluoro-methanesulfonic acid 134 Cyclohexyl- [5- (3 , 4-dimethoxy-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -amine 135 [5- (3-Bromo-4-methoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -cyclohexyl -amine 135.1 Cyclohexyl- [5- (4-methoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine 135.2 Cyclohexyl- (3-methyl-5-phenyl-3H- [1,3,4] thiadiazol- 2 -ylidene) -amine 136 3- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3 ,4] thiadiazol-2 -yl) -phenol 137 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -benzoic acid methyl ester 137.1 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2 -yl) -benzoic acid 137.2 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -N-hydroxy-benzamide 137.3 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3 ,4] thiadiazol-2-yl) -benzamide 137.4 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -N- (2H-tetrazol-5-yl) - benzamide hydrochloride salt 137.5 4- (5-Cyclohexylimi-no-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N-quinolin-8-yl- benzamide 137.6 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro[l, 3,4] thiadiazol-2-yl) -N- (2, 6-dimethoxy- pyridin-3-yl) -benzamide 137.7 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N-isopropyl-benzamide 137.8 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro [1, 3,4] thiadiazol-2-yl) -N-ethyl-benzamide 137.8-1 Cyclohexyl- {5- [4- (l-ethyl-lH-tetrazol-5-yl) -phenyl] - 3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene} -amine 137.9 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro[l,3,4] thiadiazol-2-yl) -N- (2-dimethylamino- ethyl) -benzamide 137.10 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N-pyridin-4-ylmethyl- benzamide 137.11 2-Chloro-5- (5-cyclohexylimino-4-methyl-4 , 5- dihydro[l,3,4] thiadiazol-2-yl) -N,N-diethyl- benzenesulfonamide 137.12 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -N-isobutyl-benzamide 137.13 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-methyl-benzamide 137.13- 4- (Cyclohexylimino-methyl-4, 5-dihydro- 1 [1,3,4] thiadiazol-2-yl) -N- (2-dimethylamino-ethyl) -N- methyl-benzamide 137.14 [4- (5-Cyclohexylimino-4-methyl-4 , 5 -dihydro- [1 , 3 , 4] thiadiazol -2 -yl) -phenyl] -1- (3-hydroxymethyl- piperidin-1-yl) -methanone 137.15 2 - [4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1, 3,4] thiadiazol-2-yl) -benzoylamino] -3- (4-hydroxy- phenyl) -propionic acid tert-butyl ester, 137.15- (S) -2- [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- a [1,3,4] thiadiazol-2-yl) -benzoylamino] -3- (4-hydroxy- phenyl) -propionic acid; compound with 2,2,2- trifluoro-acetic acid, 137.16 (S) -2- [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3 ,4] thiadiazol-2-yl) -benzoylamino] -propionic acid tert-butyl ester, 137.16- (S) -2- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- a [1,3,4] thiadiazol-2-yl) -benzoylamino] -propionic acid; compound with 2,2, 2-trifluoro-acetic acid 137.17 [4- (5-Cyclohexylimino-4-methyl-4,5- ihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - (4-pyridin-2-yl- piperazin-1-yl) -methanone 137.18 [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - [4- (4-fluorophenyl) -piperazin-1-yl] -methanone 137.19 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (3,4, 5-trimethoxy-benzyl) - benzamide 137.20 [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - (4-pyrimidin-2-yl- piperazin-1-yl) -methanone, 137.21 [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3 ,4] thiadiazol-2-yl) -phenyl] - (4-methyl-piperazin- 1-yl) -methanone 137.22 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- [3- (4-methyl-piperazin-l- yl) -propyl] -benzamide 137.23 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (l-ethyl-pyrrolidin-2- ylmethyl) -benzamide 137.24 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N-pyridin-3-ylmethyl- benzamide 137.25 N-Benzyl-4- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide 137.26 N- (1-Benzyl-piperidin-4-yl) -4- (5-cyclohexylimino-4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide 137.27 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-ethyl-2H-pyrazol-3-yl) - benzamide 137.28 4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-morpholin-4-yl-ethyl) - benzamide 137.28- [5- (4- ( (N-cyano-N' -ethylmorpholine) - 1 carboximidamide) -phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine 137.29 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-pyrrolidin-l-yl-ethyl) - benzamide 138 Cyclohexyl- (3-methyl-5-pyridin-3-yl-3H- [1,3,4] thiadiazol-2-ylidene) -amine 139 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide 140 (5-Benzo[l,3]dioxol-5-yl-3-methyl-3H- [1,3,4] thiadiazol-2-ylidene) -cyclohexyl-amine 141 Cyclohexyl- [3-methyl-5- (3 , 4, 5-trimethoxy-phenyl) -3H- [1,3,4] thiadiazol-2-ylidene] -amine 142 4- (5-Cyclopentylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile 143 4- (5-Cycloheptylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile — 144 4- [5- (4-Fluoro-phenylimino) -4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile 145 4- [5- (3-Hydroxy-phenylimino) -4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile 146 5- [5- (4-Cyano-phenyl) -3-methyl-3ff- [1,3,4] thiadiazol- 2 -ylideneamino] -2-fluoro-benzoic acid I47-a 4- [4-Methyl-5- (cis-4-methyl-cyclohexylimino) -4,5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile I47-b 4- [4-Methyl-5- (trans-4-methyl-cyclohexylimino) -4,5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile 148 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile 149 4- [5- (Bicyclo [2.2.1] hept-2-ylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile zo 150 - 4-[5-((lR*, 2R*) -2-Hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] - benzonitrile 151 4-[5-((lR*, 2S*) -2-Hydroxy-cyclohexylimino) -4- methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] - benzonitrile I52-a 4-[5-((lR*, 3R*) -3-Hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] - benzonitrile I52-b 4-[5-((lR*, 3S*) -3-Hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] - benzonitrile 153 (IR*, 3R*) ) -3- [5- (4-Methanesulfonyl-phenyl) -3- methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] - eye1ohexano1 154 4-[5-(lR*, 3R*) -3-Hydroxy-cyclohexylimino) -4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzoic acid 155 4-[5-((lR*, 3R*) -3-hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1, 3,4] thiadiazol-2-yl] -N- (2- morpholin-4-yl-ethyl) -benzamide 156 4- [5- (trans-4-Hydroxy-cyclohexylimino) -"-4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzoic acid 157 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -N- (2-hydroxy-l, 1- dimethyl-ethyl) -benzamide 158 4-[5-((lR*, 3R*) -3-Hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1, 3,4] thiadiazol-2-yl] -N- (2- hydroxy-1, 1-dimethyl-ethyl) -benzamide 159 N-tert-Butyl-4- [5- ( (IR*, 3R*) -3-hydroxy- cyclohexylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 160 N- (1, 1-dimethyl-3-oxo-butyl) -4- [5- (IR*, 3R*) -3- hydroxy-cyclohexylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 161 N- (2-Cyano-l,2,2-trimethyl-ethyl) -4- [5- ( (IR*, 3R*) 3-hydroxy-cyclohexylimino) -4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide -162 l-{4- [5- ( (1R*,3R*) -3 -Hydroxy-cyclohexylimino) -4- methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] - benzoylamino} -cyclopropanecarboxylic acid methyl ester 163 4- (5-Cyclopentylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide 164 4- (5-Cycloheptylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide 165 4- [5- (4-Fluoro-phenylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 166 4- [5- (3-Hydroxy-phenylimino) -4-methyl- , 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 167 5- [5- (4-Carbamoyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -2 -fluoro-benzoic acid 168 4- [4-Me.thyl-5- (4-methyl-cyclohexylimino) -4,5- dihydro- [1, 3, 4] thiadiazol-2-yl] -benzamide 169 4- [5- (4-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3, 4] thiadiazol-2-yl] -benzamide 170 4- [5- (Bicyclo[2.2.1]hept-2-ylimino) -4-methyl-4, 5- dihydro- [1, 3 , 4] thiadiazol-2-yl] -benzamide 171 4- [5- ( (1R*,2R*) -2-Hydroxy-cyclohexylimino) -4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 172 4- [5- ( (1R*,2S*) -2-Hydroxy-cyclohexylimino) -4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 173 4- [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 174 4- [5- ( (1R*,3S*) -3-Hydroxy-cyclohexylimino) -4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 174.1 4- [4-Methyl-5- (3-oxo-cyclohexylimino) -4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 175 4- [5- (3,3-Difluoro-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3 " , 4] thiadiazol-2-yl] -benzamide 176 4- [5- ( (1R*,3R*) -3-Fluoro-cyclohexylimino) -4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide 177 4- [5- (Cyclohex-3-enylimino) -4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2 -yl] -benzamide 178 (1R*,3R*) -3-{3-Methyl-5- [4- (lH-tetrazol-5-yl) - phenyl] -3H- [1, 3, ] thiadiazol-2-ylideneamino} - eye1ohexano1 179 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -2-hydroxy-benzoic acid 180 3- [5- (4-Cyano-phenyl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylideneamino] -benzoic acid 180.1 3- [5- (4-carbamoyl-phenyl) -3-methyl-3H- [1, 3 ,4] thiadiazol-2-ylideneamino] -benzoic acid 181 2-Fluoro-5- [5- (4-methanesulfonyl-phenyl) -3-methyl- 3H- [1, 3,4] thiadiazol-2-ylideneamino] -benzoic acid 182 3- [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] - cyclohexanecarboxylic acid 183 [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -piperidin-1-yl amine 184 [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1, 3,4] thiadiazol-2-ylidene] - (tetrahydro-pyran-4- yl) -amine 185 3- [5- (4-Acetylamino-phenyl) -3-methyl-3H- [1, 3,4] thiadiazol-2-ylideneamino] -benzoic acid 186 N-{4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl- 4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -phenyl} - acetamide 187 N-{4- [5- ( (1R*,3S*) -3-Hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -phenyl}- acetamide 188 N-{4- [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -phenyl}- acetamide 189 N- { 5- [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -pyridin- 2 -yl} -acetamide 190 3- [5- (4-Chloro-phenyl) -3-methyl-3H/- [1,3,4] thiadiazol-2-ylideneamino] -benzonitrile 190.1 [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , ] thiadiazol- 2 -ylidene] - [3- (lH-tetrazol-5-yl) -phenyl] -amine 190.2 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -N-hydroxy- benzamidine 190.3 3- {3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -phenyl }- [1,2,4] oxadiazol-5-ol 191 [5- (4-Bromo-3-methyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine 191.1 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -2-methyl-benzonitrile 191 . 2 4 - (5 -Cyclohexylimino-4 -methyl-4 , 5 -dihydro- [1,3,4] thiadiazol-2-yl) -2-methyl-benzamide 192 [5- (4-Bromo-3-methoxy-phenyl) -3 -methyl-2, 3-dihydro- [1,3,4] thiadiazol-2-yl] -cyclohexyl-amine 192 . 1 4 - (5 -Cyclohexylimino-4-methyl-4 , 5 -dihydro- [1,3,4] thiadiazol-2-yl) -2-methoxy-benzamide 192 .2 4 - (5 -Cyclohexylimino-4 -methyl-4 , 5 -dihydro- [1,3,4] thiadiazol-2-yl) -2-hydroxy-benzamide 193 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3 ,4] thiadiazol-2-yl) -2-nitro-benzoic acid methyl ester 193.1 2-Amino-4- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1, 3,4] thiadiazol-2 -yl) -benzoic acid methyl ester 193.2 2-Acetylamino-4- '(5-cyclohexylimino-4-methyl-4 , 5- dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester 193.3 2-Amino-4- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1 3,4] thiadiazol-2-yl) -benzamide 193 .4 7- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -3H-quinazolin-4-one 193 . 5 7- 5-Cyclohexylimino-4-methyl-4,5-dihydro- [1 3,4] thiadiazol-2-yl) -quinazolin-4-ylamine 193 . 6 7- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -lH-quinazoline-2 , 4-dione 194 4 - 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -2-methoxy-benzenesulfonamide 195 5 - 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -2-methoxy-benzenesulfonamide 196 3- [5- (3-Cyano-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol- 2-ylideneamino] -benzoic acid methyl ester 196.1 3- [5- (3-Cyano-phenyl) -3-methyl-3H- [1, 3, 4] thiadiazol- 2-ylideneamino] -benzoic acid 197.1 3- [3-Methyl-5-pyridin-2-yl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid 198 3- [5- (4-Chloro-3-sulfamoyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzoic acid 199 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile 199.1 Cyclohexyl- {3-methyl-5- [4- (lH-tetrazol-5-yl) - phenyl] -3H- [1,3,4] thiadiazol-2-ylidene} -amine 1100 Cyclohexyl- [3-methyl-5- (4-nitro-phenyl) -3H- [1,3,4] thiadiazol-2-ylidene] -amine 1100.1 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -phenylamine 1100.2 [5- (4- (N-cyano-N 1 - (2-dimethylaminoethyl) - carboximidamide) -phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine 1100.3 N- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -acetamide 1100.4 [5- (4- (bis-ethylsulfonylamino) -phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -cyclohexyl-amine, 1100.5 [5- (4- (1- (2-dimethylaminoethyl) amino-2-nitro- vinylamino) - phenyl) -3-methyl-3H- [1, 3,4] thiadiazol- 2-ylidene] -cyclohexyl-amine 1100.6 (E) -Iti 1 - [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -2-nitro-ethene-l, 1- diamine 1100.7 [5- (N-cyano-i\p -methyl-4-carboximidamide-phenyl ) -3- methyl-3H- [1, 3,4] thiadiazol-2-ylidene] -cyclohexyl- a ine 1100.8 [5- (4- (N-cyano-N' -amino- carboximidamide) -phenyl) -3- methyl-3H- [1, 3 , 4] thiadiazol-2-ylidene] -cyclohexyl- amine 1100.9 Ethanesulfonic acid [4- (5-cyclohexylimino-4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -amide 1100.10 [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -urea 1100.11 1- [4- (Cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -3- (2-dimethylaminoethyl) -urea 1101 2-Chloro-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide 1102 2-Chloro-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester 1102.1 2-Chloro-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide 1103 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide 1104 4 - (5 -Cyclohexylimino-4-methyl -4 , 5 -dihydro- [1, 3 , 4] oxadiazol-2-yl) -benzoic acid methyl ester 1104.1 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] oxadiazol-2-yl) -benzamide The compounds utilised in the invention include pharmaceutically acceptable derivatives of compounds of formula (I) such as solvates, hydrates, pharmaceutically acceptable salts and polymorphs (different crystalline lattice descriptors) . Pharmaceutically acceptable salts of a compound.. of formula (I) include salts having a basic part and salts having an acidic part . The expression pharmaceutically acceptable salt of a compound of formula (I) having a basic part should be understood to refer to the addition salts of the compounds of formula (I) which may be formed from non-toxic inorganic or organic acids such as, for example, hydrobromic, hydrochloric, sulfuric, phosphoric, nitric, acetic, succinic, tartaric, citric, maleic, hydroxymaleic, benzoic, fumaric, toluenesulfonic and isethionic acid salts, and the like. The various quaternary ammonium salts of the derivatives (I) are also included in this category of compounds of the invention. In addition, the expression pharmaceutically acceptable salt of a compound of formula (I) having an acidic part is 3fe understood to refer to the usual salts of the compounds of formula (I) which may be formed from non-toxic inorganic or organic bases such as, for example, the hydroxides of alkali metals and alkaline-earth metals (sodium, potassium, magnesium and calcium) , amines (dibenzylethylenediamine, trimethylamine, piperidine, pyrrolidine, benzylamine and the like) or alternatively quaternary ammonium hydroxides such as tetramethylammonium hydroxide. (See also "Pharmaceutical salts" by Berge S.M. et al . (1997) J. Pharm. Sci. 66 : 1-19, which is incorporated herein by reference.) . Use of a prodrug of a compound of the invention such as would occur to one skilled in the art (see Bundgaard, et al . , Acta Pharm. Suec, 1987; 24: 233-246), is also contemplated. Process for the preparation. The compounds of this invention can be synthesised according to the general procedures of synthesis A-E, utilising methodology described herein which is known to a person skilled in the art. Protocol A: The starting compounds are either commercially available or can be prepared according to routes known to 21 the skilled man. See M. Akbar Ali, S.E. Livingston, and D.J. Philipps, Inorganica Chimica Acta, 6, 11 (1972) ; P. Molina, A. Tarraga, A. Espinosa; Synthesis, 690 (1988) ; P. Molina, A. Tarraga, A. Espinosa; Heterocycles, vol.29, N°12 (1989) . In step 1, the substituted hydrazine is reacted with carbon disulphide and with an alkyl-iodide such as methyl- iodide to form the desired 2-substituted . S- alkyldithiocarbazate (1) . Various solvents, operating conditions, bases, can be used and will be easily determined by the skilled person. For example, and without any limitation, one can use for the reaction of the substituted hydrazine with carbon disulphide an alcoholic solution of potassium hydroxide with a temperature not exceeding 15°C. Methyl iodide can be added to this solution or to a diluted solution (e.g. with water) . In step 2, the substituted S-methyldithiocarbazate is reacted with an appropriate group R3C0-X in which X is a leaving group such as halogen. Preferably, R3C0-X is an acyl chloride (R3COC1) . The reaction can be carried out in e.g. toluene as the solvent at reflux. The corresponding acylated methyldithiocarbazate (2) is obtained. In step 3, the acylated methyldithiocarbazate is cyclized into the desired 1, 3 ,4-thiadiazole. The reaction can be carried out in the presence of acetic anhydride (AA) and perchlorate HC10 4 in ether, preferably, at a temperature comprised between -5 and 5°C, preferably 0°C, or in the presence of trimethylsilyl trifluoromethanesulfonate in dichloromethane, preferably, at a temperature comprised between 0 and 25°C. After stirring at room temperature several hours, an intermediate compound which is the 1,3,4- thiadiazolium perchlorate (3) is obtained. In step 4, the 1, 3, 4-thiadiazole (or its perchlorate or sulfonate) is reacted with a suitable amine R1NH 2 , to form the final compound. The reaction can be carried out in alcool such as ethanol as a solvent (the solvent may also be an aprotic solvant such as dioxane, dimethylformamide (DMF) or acetonitrile) , in the presence of a base such as triethylamine, and preferably, at a temperature comprised between 40 and 110°C, preferably between 40 and 80°C. Protocol B : The starting compounds are either commercially available or can be prepared according to routes known to the skilled person. See R. Noto, P. Lo Meo, M. Gruttadauria, G. erber ; J " . Heterocyclic Chem. , 33, 863 (1996). In step 1, the substituted isothiocyanate is reacted with the substituted hydrazine to form the desired substituted thiosemicarbazide (5) . The reaction, can be carried out in alcool e.g. methanol and/or water at a temperature comprised between -5°C and 15°C, preferably 0°C. In step 2, the substituted thiosemicarbazide is reacted with an aldehyde R3CHO to form the desired thiosemicarbazone (6) . The reaction can be carried out in alcool e.g. methanol, at a temperature comprised between 50 and 90°C, preferably 75°C. In step 3, the substituted thiosemicarbazone is cyclized to yield compound (I) . The reaction can be carried out in alcool, e.g. ethanol, at a temperature comprised between 20 °C and 110 °C, preferably 75 °C, in the presence of an oxidant such as FeCl 3 . Protocol C : 3R The starting compounds are either commercially available or can be prepared according to routes known to the skilled man. See FR-A-7712352, DE-A-4418066 and FR-A-8015072. In the first step, the carboxylic acid is reacted with the thiosemicarbazide derivative (5') to yield the desired 1, 3 ,4-thiadiazole (7) . The reaction can be carried out in an aprotic solvant such as dioxane, at reflux, in the presence of a deshydrating agent, eg P0C1 3 . In the second step, the desired 1, 3 ,4-thiadiazole is reacted with R2X, where X is a leaving group such as trifluoromethane sulfonate, iodide or bromide . *" The reaction can be carried out in an aprotic solvent such as dioxane or DMF (if R2-X is alkyl-iodide or bromide) , preferably at room temperature (RT) or under heating to yield compound (I) . Protocol D : 1 step The starting compounds are either commercially available or can be prepared according to routes known to the skilled man. In the first step, the carboxylic acid is reacted with the substituted thiosemicarbazide derivative (5) to yield the desired final 1, 3,4-thiadiazole (I) . The reaction can be carried out in an aprotic solvent such as dioxane, at reflux and at a temperature comprised between 75 and 120°C, in the presence of a deshydrating agent, e.g P0C1 3 . The solvent, reaction time, temperature, catalyst if any, can be varied in all steps described above for all routes, as the skilled man will appreciate. Protocol E : 3 step See J.M. Kane, M.A. Staeger, Synthetic communication, 22 (1) , 1-11 (1992) . The starting compounds are either commercially available or can be prepared according to methods known to the skilled person. See R. Noto, P. Lo Meo, M. Gruttadauria, G. erber ; J. Heterocyclic Chem. , 33, 863 (1996). In step 1, the substituted isothiocyanate is reacted with the substituted hydrazine to form the desired substituted thiosemicarbazide (5) . The reaction can be carried out in alcool e.g. methanol and/or water at a temperature comprised between -5 and 15°C preferably 0°C. In step 2, the substituted thiosemicarbazide is reacted with the acid chloride to form the desired thiosemicarbazide (8) . The reaction can be carried out in a basic medium such as pyridine at room temperature, or in an aprotic solvent in the presence of a base such as pyridine or triethylamine. In step 3, the substituted thiosemicarbazide is cyclized to yield compound (I) . The reaction can be carried out in alcool, e.g. methanol, at a temperature of e.g. 75°C, in the presence of Mercuric oxide (HgO) . 5 Pharmaceutical compositions. The products of the invention are administered in the form of compositions, which are appropriate depending on the nature, and severity of the condition to be treated. The daily dose in humans is usually between 2 mg and 1 g of the 10 active ingredient, which may be taken in one or more individual doses. The compositions are prepared in forms which are compatible with the intended route of administration, such as, for example, tablets, coated tablets, capsules, mouthwashes, aerosols, powders for 15 inhalation, suppositories, enemas, foams (such as rectal foams) gels or suspensions. These compositions are prepared by methods which are familiar to those skilled in the art and comprise from 0.5 to 60% by weight of active ingredient (compound of the invention) and 40 to 99.5% by weight of a 20 pharmaceutical vehicle or carrier which is appropriate and compatible with the active principle and the physical form of the intended composition. Solid form preparations include powders, tablets, dispersible granules, capsules, cachets, and suppositories. 25. A solid carrier can be one or more substances which may also act as diluents, flavouring agents, solubilizers, lubricants, suspending agents, binders, or tablet disintegrating agents; it can also be an encapsulating material. In powders, the carrier is a finely divided solid, 30 which is in a mixture with the finely divided active component. In tablets, the active component is mixed with the carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired. The powders, tablets, cachets or encapsulated forms 35 for capsules preferably contain 5% to about 70% of the active component. Suitable carriers are magnesium carbonate, magnesium stearate, talc, lactose, sugar, pectin, dextrin, starch, tragacanth, methyl cellulose, sodium carboxymethyl cellulose, a low-melting wax, cocoa butter, and the -like. Tablets, powders, cachets, and capsules can be used as solid dosage forms suitable for oral administration. The drug may be delivered as a spray (either in a pressurised container fitted with an appropriate valve or in a non- pressurised container fitted with a metering valve) . Liquid form preparations include solutions, suspensions, and emulsions. Sterile water or water-propylene glycol solutions of the active compounds may be mentioned as an example of liquid preparations suitable for parenteral administration. Liquid preparations can also be formulated in solution in aqueous polyethylene glycol solution. Aqueous solutions for oral administration can be prepared by dissolving the active component in water and adding suitable colorants, flavouring agents, stabilizers, and thickening agents as desired. Aqueous suspensions for oral use can be made by dispersing the finely divided active component in water together with a viscous material such as natural synthetic gums, resins, methyl cellulose, sodium carboxymethyl cellulose, and other suspending * agents known to the pharmaceutical formulation art. For preparing suppository preparations, a low-melting wax such as a mixture of fatty acid glycerides and cocoa butter is first melted and the active ingredient is dispersed therein by, for example, stirring. The molten homogeneous mixture is then poured into convenient sized molds and allowed to cool and solidify. Enemas are obtained according to known procedures to prepare solutions adapted for rectal administration. Foams are prepared according to known methods (these foams can notably be similar to those used to administer a drug such as 5-ASA for treating rectocolite) . Preferably the pharmaceutical preparation is in unit dosage form. In such form, the preparation is divided into unit doses containing appropriate quantities of drug. The unit dosage form can be a packaged preparation, the package containing discrete quantities of the preparation, for example, packaged tablets, capsules, and powders in vials or ampoules. The unit dosage form can also be a capsule, cachet, or tablet itself, or it can be the appropriate number of any of these packaged forms . Methods of treatment . The compounds of the invention are selective PDE7 inhibitors. They can be used in the treatment of various diseases, as they can modulate inflammatory and immunological processes due to an increase of intracellular cAMP levels. The diseases that can be successfully treated include namely T-cell-related diseases, autoimmune diseases, inflammatory diseases, respiratory diseases, CNS diseases, allergic diseases, endocrine or exocrine pancreas diseases, gastrointestinal diseases, visceral pain, inflammatory bowel disease, osteoarthritis, multiple sclerosis, chronic obstructive pulmonary disease (COPD) , asthma, cancer, acquired immune deficiency syndrome (AIDS) or graft rejection. The compounds of the invention have low IC50 values, typically at most 5 μM, preferably below 1 μM, and even below 100 nM. The invention finally relates to a method for ■ the treatment of the above-mentioned diseases comprising administering to a mammal, particularly a human, in need thereof an effective amount of compound of the invention. The following examples illustrate the invention without limiting it. Examples Compounds of the invention have been named with the software "AutoNom Version 4.0" Protocol A : Intermediate 1 ; PROTOCOL A Intermediate la: R2= methyl N-Methyl-hydrazinecarbodithioic acid methyl ester Methylhydrazine (370 mmol, 19.43 mml) was added to a solution of potassium hydroxide (370 mmol, 20.7 g) in 90% aqueous alcohol (130 mL) . The mixture was cooled to 5°C, then carbon disulphide (370 mmol, 22.2 ml) was added dropwise with vigorous stirring, over lh, while the temperature of the mixture was not allowed to rise above 7°C. The resulting yellow solution was diluted with water (300 ml) and the methyl iodide (370 mmol, 23.34 ml) was added slowly while the mixture was stirred vigorously. After the stirring had been continued for 3 h at 10-15°C, the white crystals of 2 -methyl-S-methyldithiocarbazate (la) were filtered off, washed with a mixture 1:1 of ethanol :petroleum ether to give 38 g of the desired compound. Yield: 84%. X H-NMR (400MHz, DMSO) δ ppm: 2.32 (s, 3H) , 3.60 (s, 3H) , 5.55 (s, 2H) . Intermediate 2 : PROTOCOL A Intermediate 2a: R2= methyl, R3= -chloro-phenyl N' - [1- (4-Chloro-phenyl) -methanoyl] -JW-methyl- hydrazinecarbodithioic acid methyl ester The appropriate acyl chloride (73.39 mmol, 9.30 ml) (R3COC1) was added to a suspension of 2-methyl-S- methyldithiocarbazate (73.39 mmol, 10 g) in toluene (80 ml). The mixture was stirred at reflux for 4h then allowed to cool down overnight. The solids were isolated by filtration, washed with water and then with ether to give 15 g of the expected 3-acyl-2-methyl-S-methyldithiocarbazate (2a) . Yield= 74% ^Η-NMR (400MHz, DMSO) δPPm: 2.45 (s, 3H) , 3.65 (s, 3H) , 7.65 (dd, 2H) , 7.90 (dd, 2H) , 11.68 (s, IH) . Intermediate 2b: R2= methyl, R3= 4- (methylsulfonyl) -phenyl N' - [1- (4-Methanesulfonyl-phenyl) -methanoyl] -JJT-methyl- hydrazinecarbodithioic acid methyl ester The acid chloride was prepared from the corresponding benzoic acid. The appropriate acyl chloride (1.68 mmol, 0.39 g) was added to a suspension of 2-methyl-S-methyldithiocarbazate (1.77 mmol, 0.24 g) in toluene (2 ml). After 5h at reflux, the mixture was cooled down overnight, triturated in ether and stirred over 2 h at RT to give 440 mg of the expected product (2b) as a white solid. Yield= 82% - ^-NMR (400MHz, DMSO) δ PPm: 2.5 (s, 3H) , 3.30 (s, 3H) , 3.65 (s, 3H) , 8.15 (m, 4H) , 11.9 (s, IH) . Intermediate 2c: R2= methyl, R3= 4-cyano-phenyl N* - [1- (4 -Cyano-phenyl) -methanoyl] -N-methyl- hydrazinecarbodithioic acid methyl ester The appropriate acyl chloride (22.77 mmol, 3.77 g) (R3COC1) was added to a suspension of 2-methyl-S-methyldithio carbazate (22.77 mmol, 3.10 g) in toluene (25 ml). The mixture was stirred at reflux for 3h-3h30 then allowed to cool down overnight. The solids ' were isolated by filtration, washed with water then with ether and dried to give 4.15 g of the expected 3-acyl-2-methyl-S-methyldithiocarbazate (2c) . Yield= 68% X H-NMR (400MHz, DMSO) δppm; 2.45 (s, 3H) , 3.65 (s, 3H) , 8.05 (m, 4H) , 11.85 (s, IH) . Intermediate 2d: R2= methyl, R3= 4-acetyamino-phenyl N' - (4-Acetylamino-benzoyl) -N-methyl-hydrazinecarbodithioic acid methyl ester The acid chloride was prepared from the corresponding benzoic acid. To a suspension of the appropriate acyl chloride (10 mmol, 1.4 g) in toluene (30 ml), was added triethylamine (20 mmol, 2.8 ml) followed by 2-methyl-S-methyldithiocarbazate (12 mmol, 2.4 g) . The mixture was maintained at 90°C for 2 hours and was concentrated under reduced pressure. The residue was taken into dichloromethane, washed once with water, concentrated under reduced pressure and washed with AcOEt to give 1.28 g of the title compound. Yield= 45% X H-NMR (400MHz, DMSO) δ PPm: 2.10 (s, 3H) , 2.45 (s, 3H) , 3.65 (s, 3H) , 7.85 (d, 2H) , 7.90 (d, 2H) , 10.30 (s, IH) , 11.40 (s, IH) . Intermediate 2e: R2= methyl, R3= 4-acetylamino-3-pyridyl N" - (6-Acetylamino-pyridine-3-carbonyl) -N-methyl- hydrazinecarbodithioic acid methyl ester The acid chloride was prepared from the corresponding benzoic acid. To a suspension of the appropriate acyl chloride (63 mmol, 11 g) in toluene (150 ml) was added triethylamine (130 mmol) followed by 2-methyl-S-methyldithiocarbazate (62 mmol, 9 g) . After 3h at room temperature, the mixture was concentrated under reduced pressure. The residue was taken into dichloromethane, washed once with water, concentrated under reduced pressure and " purified by chromatography on silica gel (95:5 (dichloromethane (DCM) /MeOH) to give 9 g of the title compound. Yield= 50% X H-NMR (400MHz, DMSO) ppm: 2.15 (s, 3H) , 2.45 (s, 3H) , 3.65 (s, 3H) , 8.25 (m, 2H) , 8.80 (s, IH) , 10.90 (s, IH) . MS (m/z) / +l= 298.99 Intermediate 3 : PROTOCOL A Intermediate 3a: R2= methyl, R3= 4-chloro-phenyl 1,3,4-Thiadiazolium, 5- (4-chlorophenyl) -3-methyl-2- (methylthio) -perchlorate To a suspension of the (2a) (54.4 mmol, 15 g) in ether (150 ml) at 0°C, acetic anhydride (30 ml) was added slowly and then HC10 70% (65.33 mmol, 5.61 ml) was added dropwise at 0°C for 1 hour. The resultant mixture was stirred at RT overnight and the precipitate separated -by filtration, was washed with ether and then air dried to give 19 g of the title compound (3a) as white solid. Yield= 97%. ^Η-NMR (400MHz, DMSO) δ P^i: 2.92 (s, 3H) , 3.99 (s, 3H) , 7.52 (dd, 2H) , 7.82 (dd, 2H) . MS (m/z) / M+l = 257/259 Intermediate 3b : R2= methyl, R3= 4- (methy1sulfonyl) phenyl 1,3,4 - Thiadiazolium, 5- (4-Methanesulfonyl-phenyl) -3- methyl-2- (methylthio) -perchlorate To a suspension of the (2b) (0.69 mmol, 0.22 g) in ether (3 ml) at 0°C, acetic anhydride (0.4 ml) was added slowly and then HC10 4 70% (0.90 mmol, 0.080 mL) was added dropwise at 0°C for 1 hour. The resultant mixture was then allowed to rise to RT and stirred for 3h. The precipitate was isolated by filtration then air dried to give 220 mg of the expected 3-methyl-2-methylthio [1,3,4] thiadiazolium perchlorate (3b) as a white solid. Yield= 78% ^Η-NMR (400MHz, DMSO) δ Ppm: 3.14 (a, 3H) , 3.33 (s, 3H) , 4.20 (s, 3H) , 8.20 (dd, 2H) , 8.25 (dd, 2H) . MS (m/z) / M+l = 301/303 Intermediate 3c: R2= methyl, R3= 4-cyano-phenyl 1,3,4 - Thiadiazolium, 5- (4-cyanophenyl) -3-methyl-2- (methylthio) -perchlorate To a suspension of intermediate (2c) (15.64 mmol, 4.15 g) in ether (50 ml) and acetic anhydride (13.3 ml), HC10 4 70% (18.76 mmol, 1.6 ml) was added dropwise at 0°C and stirred during 15-30 minutes at 0°C. The resultant mixture was stirred during 1H30 at room temperature and the precipitate, separated by filtration, was washed with ether and then air dried to give 5.22 g of the title compound (3c) as white solid. Yield= 96%. Η-NMR (400MHz, DMSO) δ PP™: 3.15 (s, 3H) , 4.21(s, 3H) , 8.15 (m, 4H) . Intermediate 3d: R2= methyl, R3= 4-acetylamino-phenyl 1,3,4-thiadiazolium, 5- (4-Acetylaminophenyl) -3-methyl-2- (methylthio) -trifluoro ethanesulfonic acid To a suspension of (2d) (4.3 mmol, 1.28 g) in dichloromethane (15 ml) was added trimethylsilyl trifluoromethane-sulfonate (12.9 mmol, 2.34 mL) dropwise. The resulting mixture was stirred overnight. The precipitate was isolated by filtration and then dried under reduced pressure to give 1.3 g of the expected 3 -methyl-2- methylthio [1, 3,4] thiadiazolium triflate (3d) as a white solid. Yield= 72% X H-NMR (400MHz, DMSO) δ PP™: 2.10 (s, 3H) , 3.10 (s, 3H) , 4.15 (s, 3H) , 7.80 (dd, 2H) , 7.95 (dd, 2H) , 10.40 (a, IH) . Intermediate 3e: R2= methyl, R3= 4-acetylamino-3 -pyridyl 1,3,4-thiadiazolium, 5- (6-acetylamino-pyridin-3-yl) -3- methyl-2- (methylthio) -perchlorate To a suspension of (2e) (3.4 mmol, 1 g) in ether (11 ml) was slowly added acetic anhydride (2 ml) followed by HC10 4 70% (4 mmol, 0.7 g) dropwise at 0°C over 1 hour. The resulting mixture was then allowed to warm up to room temperature and stirred overnight. Additional HC10 4 70% (0.7 mmol, 0. lg) was added at 0°C and the mixture was stirred for 2h. The precipitate was isolated by filtration washed with AcOEt then dried under reduced pressure to give 1 g of the expected (3e) . Yield = 77% ^-NMR (400MHz, DMSO) δ PP™: 2.15 (s, 3H) , 3.15 (s, 3H) , 4.20 (s, 3H) , 8.30 (dd, IH) , 8.40 (dd, 2H) , 8.90 (d, H) , 11.05 (s, IH) . MS (m/z) / M+l = 280.92 Compound I : PROTOCOL A Example II: Rl= 3-benzoic acid, R2= methyl, R3= -chloro- phenyl 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid To a suspension of 1,3,4-thiadiazolium perchlorate (3a) (0.7 mmol, 0.25 g) in ethanol (3.5 ml), 3-aminobenzoic acid (1.05 mmol, 0.144 g) and triethylamine (0.7 mmol, 0.098 ml) were added, and the mixture was maintained at 70°C for 7 hours. On cooling to RT overnight, the solid formed was isolated by filtration to give 0.180 g of the expected compound. Yield= 74.3% X H-NMR (400MHz, DMSO) δ PPm: 3.72 (s, 3H) , 7.30 (dd,- IH) , • 7.5 (dd, IH) , 7.54 (dd, 2H) , 7.60 (s, IH) , 7.54 (dd, IH) , 7.71 (dd, 2H) , 12.91-13.04 (b, IH) . HPLC (uv purity, λ= 214 nm) = 99.03% The following compounds were prepared by the procedure described in example i.l using appropriate intermediates and reagents. The desired products were obtained after purification by chromatography on silica gel. 11.1 (1R*,2R*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylideneamino] - cyclohexanecarboxylic acid To Example 11.10: Rl= 3-carboxylic acid cyclohexyl, R2= methyl, R3=s 4-chloro-phenyl 3- [5- (4-Chloro-phenyl) -3-methyl-3ff- [1,3,4] thiadiazol-2- ylideneamino] -cyclohexanecarboxylic acid Compound 11.10 was prepared by the procedure described in example II (3h at 75°C) using appropriate intermediates and reagents (protocol A) . The mixture was filtered and the filtrate was evaporated to dryness. The residue was purified by silica gel chromatography eluting with dichloromethane containing from 0 to 5% of methanol and then isocratic elution with DCM / MeoH (90/10) . Yield= 7.0% X H-NMR (400MHz, DMSO) δPPm: 0.95-1.20 (m, 4H) , 1.62-1.74 (m, 3H) , 1.74-1.80 (m IH) , 2.10-2.13 (b, IH) , 2.39-2.48 (b, IH) , 2.84-2.90 (m, IH) , 3.10 (3H, s) , 7.33 (dd, 2H) , 7.44 (dd, 2H) , 11.89-11.84 (b, IH) . rι MS (m/z) / M+l = 352/354 HPLC (uv purity, λ= 2-14 nm) = 97.61% Example 12: Rl= 2-benzoiσ acid, R2= methyl, R3= 4-chloro- phenyl 2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid To a suspension of 1,3,4-thiadiazolium perchlorate (3a) (0.7 mmol, 0.25 g) in ethanol (3 ml), 2-aminobenzoic acid (0.84 mmol, 0.115 g) and triethylamine (0.7 mmol, 0.098 ml) were added, and the mixture was heated at 70°C for 7 hours. On cooling, the solid formed was filtered off to give 210 mg of the expected compound. Yield= 87% X H-NMR (400MHz, DMSO)δ PPm: 3.8 (s, 3H) , 7.20 (m, IH) , 7.2.8 (dd, IH) , 7.56-7.64 (m, 3H) , 7.78 (dd, 2H) , 7.95 (dd, IH) , 13.52-13.59 (b, IH) . MS (m/z) / M+l= 346/348 HPLC (uv purity, λ= 214 nm) = 97.64% Example 12.1: Rl= (4-fluoro) -3 benzoic acid, R2= methyl, R3= 4-chloro-phenyl 5- [5- (4-Chloro-phenyl) -3-methyl-3H [1, 3,4] thiadiazol-2- ylideneamino] -2-fluoro-benzoic acid Compound 12.1 was prepared by the procedure described in example 2 using appropriate intermediates and reagents (protocol A) . The precipitate obtained on cooling was washed with EtOH to give 0.250 g of the title compound. Yield= 60% ^-N R (400MHz, DMSO) δ Pm: 3.71 (s, 3H) , 7.29-7.33 (m, 3H) , 7.48-7.51(m IH) , 7.54 (dd, 2H) , 7.70 (dd, 2H) , 13.27-13.29 (b, IH) . MS (m/z) / M+l= 364/366 HPLC (uv purity, λ= 214 nm) = 95.77% Example 12.2: Rl= (2,4,5-fluoro) -3 benzoic acid, R2= methyl, R3= 4-chloro-phenyl 3- [5- (4-Chloro-phenyl) -3-methyl -3H- [1,3,4] thiadiazol-2- ylideneamino] -2, 5, 6-trifluoro-benzoic acid Compound 12.2 was prepared by the procedure described in example 12 using the appropriate intermediates and reagents. Acetonitrile was used as solvent and the reaction was warmed at 80°c for 24h (protocol A) . The solid formed after cooling was filtered off and washed with MeOH to give 0.250 g of the title compound. Yield= 48.6% X H-NMR (400MHz , DMSO) δ PP 3 . 74 ( s , 3H) , 7 . 44 - 7 . 54 (m, IH) , 7 . 55 (dd , 2H) , 7 . 73 (dd, 2H) , 14 . 15 - 14 . 30 (b , IH) . MS (m/z) / M+l= 400/402 HPLC (uv purity, λ= 214 nm) = 95.82% Example 13: Rl= propyl, R2= methyl, R3= 4-chloro-phenyl [5- (4-Chloro-phenyl) -3-methyl-3JT- [1,3,4] thiadiazol-2- ylidene] -propyl-amine To a suspension of 1,3,4-thiadiazolium perchlorate (3a) (0.28 mmol, 0.10 g) in methanol (4 ml), propylamine (1.35 mmol, 0.115 ml) and triethylamine (0.28 mmol, 0.038 ml) were added, and the reaction was heated at 55°C for 5 hours. On cooling, the mixture was evaporated to dryness and the crude was chromatographed on silica gel (Alltech column, 2 g silica) with a mixture of cyclohexane :EtOAc (98:2) to give the expected compound. Yield= 0.03g, 45.2%. X H-NMR (400MHZ, DMSO) § ppm: 1.89 (t, 3H) , 5.53-5.65 (m, 2H) , 2.97 (t, 2H) , 7.49 (dd, 2H) , 7.62 (dd, 2H) . MS (m/z) / M+l= 268/270 HPLC (uv purity, λ= 214 nm) = 97.60% The following compounds were prepared by the procedure described in example 13 using appropriate intermediates and reagents. 5 ~ 3 The following compounds were prepared by the procedure described in example 13 using appropriate intermediates and reagents and with isopropanol as solvent. 13.11 2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -2-methyl-propan-1- ol 13.12 2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -2-hydroxymethyl- propane-1, 3-diol 13.13 tert-Butyl- [5- (4-chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine 13.14 [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3, 4] thiadiazol- ^ Example 13.25: Rl= (IR*, 2S*) -cyclohexyl-2 -ol, R2= methyl, R3= 4-chloro-phenyl (IR*, 2S*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] hiadiazol-2-ylideneamino] -cyclohexanol The compound 13.25 was prepared by the procedure described in example 13 (protocol A) with isopropanol as solvent. The title product was isolated by chromatography on silica gel (Alltech, 2g silica) eluting with dichloromethane containing from 0 to 1% methanol. Yield= 0.015 g, 12% X H-NMR (400MHz, DMSO) δPPm: 1.20-1.30 (b, 2H) , 1.40-1.50 (b, 2H) , 1.50-1.72 (b, 4H) , 2.80-2.83 (b, IH) , 3.50 (s, 3H) , 3.55-3.60 (b, IH) , 4.02-4.04 (b, IH) , 7.45 (d, 2H) , 7.60 (d, 2H) . MS (m/z) / M+l= 324/3256 HPLC (uv purity, λ= 214 nm) = 96.62% The following compound was prepared by the procedure described in example 13 with isopropanol as solvent. 13.26 [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene] - (4-trifluoromethyl-phenyl) -amine Example 14: Rl= 3-benzoic acid, R2= methyl, R3= 4- (methanesulfonyl) -phenyl 3- [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol -2-ylideneamino] -benzoic acid To a suspension of 1,3,4-thiadiazolium perchlorate (3b) (0.547 mmol, 0.22 g) in ethanol (2.5 ml), 3-aminobenzoic acid (0547 mmol, 0.075 g) and triethylamine (0.601 mmol, 0.084 ml) were added, and the reaction was maintained for 6 hours at 75°C. On cooling overnight, the precipitate was filtered off, washed with ethanol then purified on silica gel, eluted with a gradient of DCM then DCM:MeOH (95:5) to give 70 mg of the expected compound. Yield= 33% H-NMR (400MHz, DMSO) δ PP™ 3.78 (s, 3H) , 7.31 (dd, IH) ,: 7.54 (dd, IH) , 7.60 (s, IH) , 7.65 (a, IH) , 7.97 (dd, 2H) , 8.03 (dd, 2H) , 12.92-12.03 (b, IH) . MS (m/z) / M+l= 390 HPLC (uv purity, λ= 214 nm) = 95.14% The following compounds were prepared by the procedure described in example 14 wit an excess of triethylamine (lOeq) and of the appropriate amine (lOeq) . The reaction was refluxed for 5h. 14.1 [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene] -cyclopropyl-amine 14.2 [5- (4-Chloro-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol- 5 ~ k 2-ylidene] -cyclohexylmethyl-amine Example 15: Rl= 3-hydroxyphenyl, R2= methyl, R3= 4- chlorophenyl 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -phenol In this example, polystyrene morpholine resin was used to replace triethylamine and the isocyanate resin to remove the remaining amino derivative. The suspension of morpholine resin (0.70 mmol, 0.20 g) and 3-aminophenol (0.84 mmol, 0.09 g) in ethanol (3.5 ml) was stirred at RT for 5 min before the addition of 1,3,4- thiadiazolium perchlorate (3a) (0.70 mmol, 0.25 g) . After 5 hours at 70°C, the mixture was allowed to cool down before the filtration of the resin. The crude obtained after the evaporation of the solvent was purified on chromatography gel (Alltech column, 2 g silica) and eluted with gradient of DCM and MeOH:DCM (99:1) to give a mixture (0.07 g) of the remained amino derivative and the expected compound. To this mixture in DCM (7 ml) / MeOH (0.5 ml), was added the isocyanate resin (2.44 mmol, 2.00 g) and the suspension was stirred at RT overnight. After filtration of the resin, the filtrate was evaporated to dryness to give 30 mg of. the pure product . Yield= 13.5% X H-NMR (400MHz, DMSO) δ PPm: 3.68 (s, 3H) , 6.45-6.51 (m, 3H) , 7.13-7.19 (m, IH) , 7.55 (dd, 2H) , 7.71 ( dd, 2H) , 9.40- 9.48 (b, IH) . MS (m/z) / M+l= 318/320 HPLC (uv purity, λ = 214 nm) = 98.44% Example 16: Rl= 4-hydroxy-3 -benzoic acid, R2= methyl, R3= 4- chlorophenyl 5- [5- (4-Chloro-phenyl) -3 -methyl-32ϊ- [1, 3 ,4] thiadiazol-2- ylideneamino] -2-hydroxy-benzoic acid The compound 16 was prepared by the procedure described in example 12 (protocol A) . The precipitate obtained on cooling was washed with DCM then p rur?ified by chromatography on silica gel (Alltech column, 5g silica) eluted with a mixture of DCM/MeOH from 100/0 to 85/15. Yield= 17.0% X H-NMR (400MHz, DMSO) δ p m: 3.07 (s, IH) , 3.59 (s, 3H) , 6.70 (d, IH) , 6.93-6.98 (m IH) , 7.30 (s, IH) , 7.38-7.41 (m, 2H) , 7.57-7.62 (m, 2H) . MS (m/z) / M+l= 362/364 HPLC (uv purity, λ= 214 nm) = 95.89% The follpwing compounds were prepared by the procedure described in example 16, using appropriate intermediates and reagents. Either morpholine resin or pyridine was used to replace triethylamine . " ? 1,3 -diamine 16.11 3- [5- (4-Chloro-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzamide Example 17: Rl= Exo-2-norbornyl, R2= methyl, R3= 4-chloro- phenyl Bicyclo[2.2.1]hept-2-yl- [5- (4-chloro-phenyl) -3 -methyl -3H- [1,3,4] thiadiazol-2-ylidene] -amine The compound 17 was prepared by the procedure described in example 13 using appropriate intermediates and reagents (protocol A) . The title product was isolated by chromatography on silica gel (Alltech, 2g silica) with a gradient of cyclohexane: EtOAc from 100: 0 to 97:3 Yield= 44.8 % X H-NMR (400MHz, DMSO) δ PPm: 1.09-1.18 (b, 3H) , 1.27-1.33 (b, IH) , 1.40-1.52 (b, 2H) , 1.58-1.62 (m, IH) , 1.70-1.76 (m, IH) , 1.99-2.10 (b, IH) , 2.24-2.27 (b, IH) , 3.45 (s, 3H) , 7.53 (d, 2H) 7.64 (d, 2H) . MS (m/z) / M+l= 320/322 HPLC (uv purity, λ= 214 nm) = 93.17% Example 18: Rl= (IR*, 2R*) -cyclohexyl-2-ol, R2= methyl, R3= 4-chloro-phenyl (1R*,2R*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol The compound 18 was prepared by the procedure described in example 13 using appropriate intermediates and reagents (protocol A) . Triethylamine was replaced by morpholine resin (2.1 mmol, 0.61 g, loading 3.47 mmol/g) ; the mixture of morpholine resin and trans-2-aminocyclohexanol hydrochloride (2.1 mmol, 0.318 g) was stirred in ethanol (3.5 ml) at RT for 5 min before the addition of 3-methyl-2- methylthio [1, 3 , 4] thiadiazolium perchlorate (3a) (0.7 mmol, 0.25 g) . The residue was subjected to silica gel chromatography ( Alltech column, 2g silica) eluting with dichloromethane containing from 0 to 1% methanol . Yield= 0.050g, 22% X H-NMR (400MHz, DMSO) δ PP™: 1.10-1.25 (m, 4H) , 1.50-1.66 (m, 3H) , 1.71-1.79 (b, IH) , 2.28-2.33 (m, IH) , 3.21-3.27 (m, IH) , 3.40 (s, 3H) , 4.38 (s, IH) , 7.42 (dd, 2H) , 7.54 (dd, 2H) . HPLC (uv purity, χ= 214 nm) = 99.9% The following compounds were prepared by the procedure described in example 18 using appropriate intermediates and reagents . 18.1 5- (5-Cyclohexyl-3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino) -2-methoxy-phenol 18.2 3 - (5-Cyclohexyl-3 -methyl-3H- [1,3,4] thiadiazol-2- ylideneamino) -benzoic acid 18 . 3 3 - [5- (4-Chloro-phenyl) -3 -methyl-3H- [1 , 3 , 4] thiadiazol-2 -ylideneamino] -4 -hydroxy-benzoic acid 18.4 (5-Cyclohexyl-3 -methyl-3H- [1,3,4] thiadiazol-2- ylidene) - (3 -methanesulfonyl-phenyl) -amine Example 19: Rl= (IR*, 2R*) -cyclohexyl-2-ol, R2= methyl, R3= 4- (methanesulfonyl) -phenyl (IR*, 2R*) -2- [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol The compound 19 was prepared by the procedure described in example 14 (protocol A) . 3 -methyl-2 -methylthio [1,3,4] thiadiazolium perchlorate (3b) (0.372 mmol, 0.15 g) , trans-2-aminocyclohexanol hydrochloride (0.410 mmol, 0.062 g) and triethylamine (0.7814 mmol, 0.109 ml) were reacted in ethanol (1.5 ml) . The crude was twice ' chromatographed on silica gel with a mixture of DCM: MeOH (98:2) to give the title product. Yield= 0.030g, 23% X H-NMR (400MHz, DMSO) PPm: 1.20-1.37 (m, 5H) , 1.60-1.78 (oO (b, 3H) ,1.81-1.90 (b, IH) , 3.3 (s, 3H) , 3.32-3.40 (b, IH) , 3.52 (s, 3H) , 4.53 (a, IH) , 7.89 (d, 2H) , 8.01 (d, 2H) . MS (m/z) / M+l= 368/370 HPLC (uv purity, λ= 214 nm) = 99.17% Protocol B (I) Intermediate 5 : PROTOCOL B Intermediate 5a: Rl= cyclohexyl, R2= methyl Hydrazinecarbothioamide, N- (cyclohexyl) -l-methyl The requisite cyclohexylisothiocyanate, (70.8 mmol, 10 g) was dissolved in methanol (35 ml) and this solution was added dropwise (30 min) to a stirred solution of methylhydra ' zine (134.5 mmol, 7 ml) in water (35 ml) at 0°C. After mixing, the solution was allowed to stir at RT overnight. The precipitate was removed by filtration. The solid was washed with cold EtOH to give 11.7 g of the expected derivative 5a. Yield : 88.7% X H-NMR (400MHz , DMSO) δ P ™: 1.10-1.25 (m, 5H) , 1.50-1.60 (m,lH), 1.60-1.70 (m, 2H) , 1.80-1.90 (m, 2H) , 3.40 (s,3H), 3.90-4.00 (m,lH), 4.80 (s,2H), 7.85 (d, IH) . MS (m/z) / M+l = 188,33 Intermediate 5b: Rl= cyclohexyl, R2= H Hydrazinecarbothioamide, N-cyclohexyl The requisite cyclohexylisothiocyanate, (141 mmol, 20 ml) was dissolved in methanol (30 ml) and this solution was added dropwise (35 min) to a stirred solution of hydrazinehydrate (423 mmol, 13.2 ml) in methanol (200 ml) at 0°C. After mixing, the solution was allowed to stir at RT overnight. The precipitate was removed by filtration. The solid was washed with cold EtOH to give 14.9 g of the expected derivative (5b) . Yield: 61% x H-NMR(400MHz , DMSO) § pp : 1.10-1.35 (m, 5H) , 1.50-1.60 (m,lH), 1.60-1.75(m,2H) , 1.75-1.90 (m,2H), 4.00-4.10 (m, IH) , 4.40 (s,2H), 7.50 (d, IH) , 8.50 (s,lH). MS (m/z) / M+l =174,25 Intermediate 5c: Rl= 3-benzoic-acid-methyl-ester, R2= H Hydrazinecarbothioamide,N- (3-benzoic-acid-methyl-ester) 3-methoxycarbonylisothiocyanate (77.6 mmol, 15 g) was added dropwise (30 min) to a stirred solution of hydrazine hydrate (97 mmol, 4.7 mL) in methanol (40 mL) at -10°C. After stiring at -10 °C for 5h, the solution was allowed to stir at room temperature overnight. The precipitate was filtered and washed with cold methanol to give 15.4 g of < the expected compound (yield: 88%) . X H-NMR (400 MHz , DMSO) δ PPm: 3.85 (s, 3H) , 4.85 (brs, IH) , 7.43 (t, IH) , 7.68 (d, IH) , 7.87 (d, IH) , 8.33 (s, IH) , 9.23 (s, IH) . MS (m/z) / M+l = 226 Intermediate 6: PROTOCOL B Intermediate 6a: Rl=cyclohexyl, R2=methyl , R3= 2,4- dichlorophenyl Hydrazinecarbothioamide, N-cyclohexyl-2- [ (2,4- chlorophenyl) ethylene] A suspension of 2-methylthiosemicarbazide (5a) (2.67 mmol, 500 mg) in ethanol (5 ml) and 2 , 4-dichlorobenzaldehyde (2.94 mmol, 515 mg) were heated at 75°C for 18 hours. After cooling, the formed precipitate was filtered and washed with cold ethanol to give 876 mg of the title compound. Yield: 95.3% X H-NMR (400MHz , DMSO) δ ppm: 1.10-1.25 (m, IH) , 1.25-1.35 (m, 2H) , 1.35-1.55 (m, 2H) , 1.60-1.70 (m, IH) , 1.70-1.80 (m, IH) , 1.90-2.00 (m, 2H) , 3.80 (s, 3H) , 4.10-4.30 (m, IH) , 7.50 (d, IH) , 7.70 (s, IH) , 8.00 (s, IH) , 8.20 (d, IH) , 8.50 (d, IH) . EXAMPLE I : PROTOCOL B Example 110: Rl= cyclohexyl, R2= methyl, R3= 2,4- dichlorophenyl Cyclohexyl- [5- (2,4-dichloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -amine The appropriate thiosemicarbazone (prepared by the procedure described in example 6a) (2.3 mmol, 800 mg) was suspended in ethanol (5ml) and the oxidant FeCl 3 ,6H 2 0 (5.06 mmol, 1.38 g) dissolved in ethanol (5 ml) was added. The mixture was heated at 75°C during 19h (TLC control). The oxidant (1.15 mmol, 0.31 g) was added to allow reaction to completion. The mixture was concentrated by distillation of the solvent and the crude material was solubilized in ethyl acetate. The inorganic salts were removed by extraction with water. The organic layer was washed with a solution of NaCl, dried under magnesium sulphate, filtered, and distilled to give a residue which was chromatographed on silica gel column (using a gradient of solvent ethyl acetate-cyclohexane starting with a ratio 5/95) to isolate 230 mg of the pure thiadiazoline. The byproduct mainly formed during this reaction is the 1, 2,4-triazoline-5-thione. Yield: 35% X H-NMR (400MHz , DMSO) δ ppm: 1.10-1.40 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.80 (m, 4H) , 2.55-2.70 (m, IH) , 3.50 (s, 3H) , 7.50 (d, IH) , 7.70-7.80 (m, 2H) MS (m/z) / M+l= 344.1 HPLC (uv purity, λ= 214 nm) : 99,9% Example 110.1 : Rl= cyclohexyl, R2= methyl, R3= 2-chloro- phenyl [5- (2-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 - ylidene] -cyclohexyl-amine Compound I10.1 was prepared by the procedure described in 110 using appropriate intermediates and reagent . The residue was subjected to silica gel chromatography, eluting with cyclohexane containing from 0 to 6% AcOEt. Yield: 6% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.35 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.70 (m, 4H) , 2.55-2.65 (m, IH) , 3.50 (s, 3H) , 7.40-7.50 (m, 2H) , 7.60 (d, IH) , 7.70 (d, IH) MS (m/z) / M+l= 310.2 HPLC (uv purity, λ= 214 nm) : 99.9% Example 111: Rl= cyclohexyl, R2= methyl, R3= 4- (trifluoromethyl) -phenyl Cyclohexyl- [3-methyl-5- (4-trifluoromethyl-phenyl) -3JT- [1,3,4] hiadiazol-2-ylidene] -amine The appropriate thiosemicarbazone (prepared by the procedure described in example 6a) (2 mmol, 700 mg) was suspended in ethanol (5 ml) and the oxidant FeCl 3 , 6H 2 0 (4„4 mmol, 1.21 g) dissolved in ethanol (5 mL) was added. The mixture was heated at 75°C during 19h. The mixture was concentrated by distillation of the solvent and the crude material was solubilized in ethyl acetate. The inorganic salts were removed by extraction with water. The organic layer was washed with a solution of NaCl, dried under magnesium sulphate, filtered, and distilled to give a residue which was chromatographed on silica gel column (using a gradient of solvent ethyl acetate-cyclohexane as eluent with a rapport 5/95) to isolate 290 mg the pure thiadiazoline. Yield:42% X H-NMR (400MHz, DMSO) δ PP™: 1 • 25-1.50 k (m, 5H) , 1.60-1.70 (m, IH) ,1.75-1.90 (m, 4H) , 2.65-2.75 (m, IH) , 3.60 (s, 3H) , 7.85-7.95 (m, 4H) MS (m/z) / M+l= 342.6 HPLC (uv purity, χ= 214 nm) : 99.9% Example 112: Rl= cyclohexyl, R2= methyl, R3= 4-pyridyl Cyclohexyl- (3-methyl-5-pyridin-4-yl-3H- [1,3,4] thiadiazol-2- ylidene) -amine Compound 112 was prepared by the procedure described in example 111 using appropriate intermediates and reagents (protocol B) . The mixture was concentrated by distillation under reduced pressure and the residue was dissolved in water. The aqueous mixture was then basified with saturated NaHC0 3 solution and extracted with ethyl acetate. The organic layer was washed with saturated solution of NaCl and dried over magnesium sulfate, filtered and distilled to give a residue which was purified by silica gel chromatography (eluent: cyclohexane/ethyl acetate, 95/5) ' . Yield: 80% X H-NMR (400MHz , DMSO) δ PPm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , .2.55-2.70 (m, IH) , 3.55 (s, 3H) , 7.60 (d, 2H) , 8.65 (d, 2H) MS (m/z) / M+l= 275.2 HPLC (uv purity, λ= 214 nm) : 99.9% ' " " Example 113: Rl= cyclohexyl, R2= methyl, R3= 3 -chloro-phenyl [5- (3-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylidene] -cyclohexyl-amine Compounds 113 was prepared by the procedure described in example 110 using appropriate intermediates and reagents (protocol B) . The residue was subjected to silica gel chromatography, eluting with cyclohexane containing from 0 to 6% AcOEt. Yield: 23% X H-NMR (400MHz , DMSO) δ PP™: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2 _ .55-2.70 (m, IH) , 3.50 (s, 3H) , 7.45-7.55 (m, 2H) , 7.55-7.65 (m, IH) , 7.70 (s, IH) MS (m/z) / M+l= 308 HPLC (uv purity, λ= 214 nm) : 99.9% Example 114: Rl= cyclohexyl, R2= methyl, R3= 4-cyano-phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzonitrile Compounds 114 was prepared by the procedure described in example 110 using appropriate intermediates and reagents (protocol B) . The residue was subjected to silica gel chromatography, eluting with cyclohexane containing from 0 to 8% AcOEt. Yield: 10% X H-NMR (400MHz , DMSO) § ppm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.80 (m, 4H) , 2.60-2.70 (m, IH) , 3.55 (s, 3H) , 7.80 (d, 2H) , 7.90 (d, 2H) MS (m/z) / M+l= 299.2 HPLC (uv purity, λ= 214 nm) : 99.3% Example 115 : Rl= cyclohexyl, R2= methyl, R3= 4- methylsulfonyl-phenyl Cyclohexyl- [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine Compounds 115 was prepared by the procedure described in example 110 using appropriate intermediates ..and reagents (protocol B) . The residue was subjected to silica gel chromatography, eluting with cyclohexane containing from 0 to 10% AcOEt. Protocol D gave better yield to prepare 115. Yield: 3% X H-NMR (400MHz , DMSO) δ PP™: 1.15-1.35 (m, 5H) , 1.45-1.55 (m, IH) , 1.60-1.75 (m, 4H) , 2.50-2.60 (m, IH) , 3.20 (s, 3H) , 3.45 (s, 3H) , 7.80 (d, 2H) , 7.90 (d, 2H) . MS (m/z) / M+l= 352.5 HPLC (uv purity, λ= 214 nm) : 87.3% Protocol C (I) Intermediate 7: PROTOCOL C Intermediate 7a: Rl= cyclohexyl, R3= 4-chloro-3-sulfamoyl- phenyl 2-Chloro-5- (5-cyclohexylamino- [1,3,4] thiadiazol-2-yl) - benzenesulfonamide To a mixture of 4-chloro-3-sulfamoyl-benzoic acid (6.36 mmol, 1.5 g) , thiosemicarbazide (5b) (6.36 mmol, 1.10 g) in dioxane (40 ml) at 60°C, P0C1 3 (6.36 mmol, 600 *" μl) was added and the mixture was warmed at reflux for 2h30 and 16h at RT. The solvent was removed by distillation under reduced pressure to give a crude material which was basified with a solution of diluted NH 4 0H. The yellow precipitate obtained was collected by filtration, washed with water before drying under vacuum over P 2 Os to give 2g of the desired product . Yield = 84 % ; X H (400MHz, DMSO)δ ppm : 1.10-1.37 (m, 5H) , 1.55 (m, IH) , 1.70 (m, 2H) , 1.98 (m, 2H) , 3.55 (m, IH) , 7.66-7.82 (m, 3H) , 7.90 (m, IH) ; 8.25-8.37 (br, 2H) . MS (m/z) / M+l = 373/375 Intermediate 7b: Rl= cyclohexyl, R3= 2, 4-dichloro-5- sulfamoyl-phenyl 2,4-Dichloro-5- (5-cyclohexylamino- [1,3,4] thiadiazol-2-yl) - benzenesulfonamide To a mixture___ of 2, 4-dichlorobenzoic acid (1.85 mmol, 500 mg) , thiosemicarbazide (5b) (1.85 mmol, 320 mg) in anhydrous dioxane (10 mL) at 70-80°C, P0C1 3 (1.85 mmol, 173 μl) was added and the mixture was warmed at 95°C for 5 hours. The solvent was removed by distillation under reduced pressure to give a crude material which was basified at pH 8-7 with a saturated solution of NaHC0 3 . The precipitate obtained was collected by filtration, washed with water and purified by silica gel chromatography using cyclohexane/ethyl acetate as eluent to give 351mg of the title compound. Yield: 46.3% X H-NMR (400MHz , DMSO) δ PPm: 1.10-1.40 (m, 5H) , 1.50-1.65 (m, IH) , 1.65-1.80 (m, 2H) , 1.90-2.05 (m, 2H) , 3.50-3.70 (m, 1H),7.85 (d, 2H) , 8.05 (s, IH) , 8.20-8.40 (m, IH) , 8.60 (s, IH) . MS (m/z) / M+l= 407.1 HPLC (uv purity, λ= 214 nm) : 97.1% Intermediate 7c: Rl= cyclohexyl, R3= 3-thienyl Cyclohexyl- (5-thiophen-3-yl- [1,3,4] thiadiazol-2-yl) -amine To a mixture of 3-thiophenecarboxylic acid (3.9 mmol, 500 mg) , thiosemicarbazide 5b (3.9 mmol, 675 mg) in anhydrous dioxane (10 ml) at 60-65°C, POCl 3 (5 mmol, 473 μl) was added and the mixture was warmed at 95°C for 5 hours. The solvent was removed by distillation under reduced pressure to give a crude material which was basified at pH 8-7 with a saturated solution of NaHC0 3 . The precipitate obtained was collected by filtration and washed with water. The solid was then dried under vacuum to provide 965 mg of the desired compound (7c) . Yield : 93% X H-NMR (40_0MHz , DMSO) δ PPm: 1.10-1.40 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.75(m, 2H) , 1.90-2.00 (m, 2H) , 3.45-3.55 (m, IH) , 7.45 (d, IH) , 7.65 (d, 1H),7. ' 80 (d, IH) , 7.85 (s, IH) . Intermediate 7d: Rl= cyclohexyl, R3= 3-chloro-2, 6- dimethoxyphenyl [5- (3-Chloro-2,6-dimethoxy-phenyl) - [1,3,4] thiadiazol-2-yl] - cyclohexyl-amine To a mixture of 3-chloro-2, 6-dimethoxybenzoic acid (2.3 mmol, 500 mg) , thiosemicarbazide 5b (2.3 mmol, 399 mg) in anhydrous dioxane (10 ml) at 70-80°C, POCl 3 (2.3 mmol, 215 μl) was added and the mixture was warmed at 95°C for 5 hours. The solvent was removed by distillation under reduced pressure to give a crude ' material which was basified at pH 8-7 with a saturated solution of NaHC0 3 . The precipitate obtained was collected by filtration, washed with water and dried under vacuum. The solid was subjected to flash chromatography eluting with ethyl acetate/cyclohexane to give 115 mg of the title compound. Yield: 14% X H-NMR (400MHz , DMSO) δ ppm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.80 (m, 2H) , 1.95-2.05 (m, 2H) , 3.50-3.60 (m, IH) , 3.70 (s, 3H) , 3.80 (s, 3H) , 7.00 (d, IH) , 7.55 (d, IH) , 7.75 (d, IH) . MS (m/z) / M+l = 354.1 Intermediate 7e: Rl= cyclohexyl, R3= 3-bromo-4-methoxyphenyl [5- (3-Bromo-4-methoxy-phenyl) - [1,3,4] thiadiazol-2-yl] - cyclohexyl-amine To a mixture of 3-bromo-4-methoxybenzoic acid (2.16 mmol, 500 mg) , thiosemicarbazide 5b (2.16 mmol, 375 mg) in anhydrous dioxane (10 ml) at 60-65°C, P0C1 3 (2.8 mmol, 262 μl) was added and the mixture was warmed at 95°C for 5 hours. The solvent was removed by distillation under reduced pressure to give a crude material which was basified at pH 8-7 with a saturated solution of NaHC0 3 . The precipitate obtained was collected by filtration, washed with water and dried under vacuum. The solid was solubilized in 50 ml of dichloromethane/methanol (7/3) to which was additionned a morpholine resin (13.88 mmol, 4 g) . The mixture was stirred overnight to remove the excess of acid. The resin morpholine salt was filtered and the organic layer was concentrated by distillation under reduced pressure to give 740 mg of the purified product (7e) . Yield: 92.8% X H-NMR (400MHz , DMSO) P m: 1.10-1.40 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.75 (m, 2H) , 1.90-2.00 (m, 2H) , 3.45-3.55(m, IH), 7.45 (dd, IH) , 7.65 (dd, IH) , 7.80 (dd, IH) , 7.85 (dd, IH) . Intermediate 7f: Rl= cyclohexyl, R3= 2-pyrazinyl Cyclohexyl- (5-pyrazin-2-yl- [1,3,4] thiadiazol-2-yl) -amine To a mixture of 2-pyrazine carboxylic acid (2.885 mmol, 0.358 g) , thiosemicarbazide (5b) (2.885 mmol, 0.5 g) in anhydrous dioxane (10 ml) , was added phosphorus oxychloride (3.751 mmol, 0.350 ml) at 90°C and the mixture was heated at 95°C for 5 hours. The mixture was then basified to pH 7 with a saturated solution of sodium bicarbonate then extracted with EtOAc . The organic phase was dried over MgS0 and evaporated to dryness to give the expected product . Yield= 0.6 g, 79.6% X H-NMR (400MHz, DMSO) δ PPm: 1.20-1.44 (m, 5H) , 1.56-1.63 (b, IH) , 1.70-1.77 (b, 2H) , 2.00-2.05 (b, 2H) , 3.60-3.68 (b, IH) , 8.22 (d, IH) , 8.67-8.69 (m, 2H) , 9.28 (s, 'IH) . Intermediate 7g: Rl= cyclohexyl, R3 =3,4-dihydroxyphenyl 4- (5-Cyclohexylamino- [1,3,4] thiadiazol-2-yl) -benzene-1, 2-diol To a mixture of 3 , 4-dihydroxybenzoic acid (2.885 mmol, 0.445 g) , thiosemicarbazide (5b) (2.885 mmol, 0.500 g) in anhydrous dioxane (10 ml) , was added phosphorus oxychloride (3.751 mmol, 0.350 ml) at 90 °C and the mixture was heated at 95°C for 5 hours. The mixture was basified with a saturated solution of sodium bicarbonate to pH 7 then stirred at RT overnight. The precipitate was filtered, washed with hexane then dried to give the title compound. 'Yield: 71% X H-NMR (400MHz , DMSO) δ ™' 1.15-1.39 (m, 5H) , 1.55-1.62 (b, IH) , 1.70-1.78 (b, 2H) , 1.95-2.00 (b, 2H) , 3.48-3.53 (b, IH) , 6.80 (d, IH) , 6.98 (d, IH) , 7.19 (s, IH) , 7.68 (d, IH) , 9.20-9.40 (b, 2H) . l Intermediate 7h: Rl = cyclohexyl, R3= 4-chloro-phenyl [5- (4-Chloro-phenyl) - [1,3,4] thiadiazol-2-yl] -cyclohexyl-amine Thiosemicarbazone (6b) (obtained from 5b following the protocol 6a) (10 mmol, 3 g) was suspended in ethanol (50 ml) and the oxidant FeCl3,6H 2 0 (23 mmol, 6.3 g) was added. The mixture was heated at reflux for 3h. The mixture was concentrated by distillation of the solvent and the crude material was solubilized in ethyl acetate. The organic layer was washed with water, dried under magnesium sulphate, filtered, and distilled to give a residue submitted to another oxidative process with FeCl 3 , 6H 2 0 (3 g) in ethanol (50 ml) . The mixture was heated at reflux for 3h and 12h at RT. The mixture was concentrated by distillation of the solvent and the crude material was solubilized in ethyl acetate. The inorganic salts were removed by extraction with water. The organic layer was washed with a solution of NaCl, dried under magnesium sulphate, filtered, and distilled to give a residue which was triturated and wash with cyclohexane to give 2.5g of the title product. Yield: 85% X H-NMR (400MHz, DMSO) δ ppm: 0.95-1.22 (m, 5H) , 1.35-1.45 (b, IH) , 1.50-1.60 (m, 2H) , 1.80-1.87 (m, 2H) , 3.32-3.42 (b, IH) , 7.35 (d, 2H) , 7.55 (d, 2H) , 7.75 (d, IH) MS (m/z) / M+l = 294.1 HPLC (uv purity, λ= 214 nm) : 97.21% Intermediate 7i: Rl= cyclohexyl, R3= 3-chloro-4-hydroxy-5- methoxypheny1 2-chloro-4- (5-cyclohexylamino- [1,3,4] thiadiazol-2-yl) -6- methoxy-phenol To a mixture of 3-chloro-4-hydroxy-5-methoxybenzoic acid (2.468 mmol, 500 g) , thiosemicarbazide (5b) (2.468 mmol, 427 mg) in dioxane (10 ml) at 65°C, P0C1 3 (3.2 mmol, 300 μl) was added and the mixture was warmed at 95°C for 3h30. The solvent was removed by distillation under reduced pressure to give a crude material which was basified with a solution of diluted NH 4 0H. The precipitate obtained was collected by 7/ filtration, washed with water before drying under vacuum over P 2 0 5 to give 675 mg of the desired product. Yield = 80% X H-NMR (400MHz, DMSO)δ PPm: 1.15-1.36 (m, 5H) , 1.53-1.63 (m, IH) , 1.67-1.80 (m, 2H) , 1.95-2.05(m, 2H) , 3.45-3.57 (m, IH) , 3.90 (s, 3H) , 7.25 (s, IH) ; 7.30 (s, IH) , 7.85 (d, IH) , 9.90 (s, IH) Intermediate 7j : Rl= 3-benzoic-acid-methyl-ester, R3= 3- cyano-phen l 3- [5- (3 -Cyano-phenyl) - [1,3,4] thiadiazol-2 -ylamino] -benzoic acid methyl ester To a mixture of 3-cyanobenzoic acid (2.92 mmol, 0.43 g) , (5c) (3 mmol, 0.7 g) in dioxane (10 mL) at 85°C, POCl 3 (3.8 mmol, 350 μL) was added and the mixture was heated at 95°C for 3h30. The solvent was removed by distillation under reduced pressure to give a crude material which was basified with an aqueous saturated solution of NaHC0 3 . The precipitate obtained was collected by filtration, washed successively with water and with ether before being dried under vacuum to give 0.5 g of the desired product (yield: 49%) . X H-NMR (400 MHz, DMSO) δ PPm: 3.88 (s, 3H) , 7.53 (t, IH) , 7.63 (d, IH) , 7.72 (t, IH) , 7.86 (d, IH) , 7.96 (d, IH) , 8.23 (d, IH) , 8.32 (s, IH) , 8.43 (s, IH) , 10.89 (s, IH) . MS (m/z) / M+l = 337 Intermediate 7k: Rl= 3-benzoic-acid-methyl-ester, R3= 2- pyridyl 3- (5-Pyridin-2-yl- [1,3,4] thiadiazol-2 -ylamino) -benzoic acid methyl ester To a mixture of picolinic acid (2.92 mmol, 0.36 g) , (5c) (3 mmol, 0.7 g) in dioxane (10 ml) at 85°C, POCl 3 (3.8 mmol, 350 μL) was added and the mixture was heated at 95°C for 5h. The solvent was removed by distillation under reduced pressure to give a crude material. Methanol was added and the precipitate obtained was collected by filtration, washed with methanol and dried under vacuum to give 0.59 g (61%) of the desired product. The crude material was engaged in the next step without purification. X H-NMR (400 MHz, DMSO) δ Ppm: 3.8 (a, 3H) , 7.5 (m, 2H) , 7.6 (d, IH) , 7.88 (d, IH) , 7.98 (t, IH) , 8.12 (d, IH) , 8.42 (s, IH) , 8.63 (d, IH) , 10.9 (s, IH) . MS (m/z) / M+l = 313/314/315 EXAMPLE I : PROTOCOL C Example 116: Rl= cyclohexyl, R2= methyl, R3= 2,4-dichloro-5- sul amoyl-phenyl 2,4-Dichloro-5- (5-cyclohexylimino-4-methy1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide To a solution of 1,3,4-thiadiazole 7b (0.195 mmol, 80 mg) in anhydrous dioxane (10 mL) , methyltrifluoromethane sulfonate (0.23 mmol, 27 μl) was added. The resultant mixture was stirred for 24 h. To this solution was added 0.527 mmol (64 μl) of methyltrifluoromethane sulfonate to allow reaction to completion, and 0.585 mmol (82 μl) of triethylamine. The filtrate is concentrated by distillation under reduced pressure. The product was purified via column chromatography on silica gel (eluted with cyclohexane/ethyl acetate, 80/20) to give 48 mg of the title product. Yield: 58% X H-NMR (400MHz , DMSO) δ PPm: 1.20-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.70 (m, IH) , 3.55 (s, 3H) , 7.80 (d, 2H) , 8.0 (S, IH) , 8.35 (s, IH) . MS (m/z) / M+l: 421.3 HPLC (uv purity, χ= 214 nm) : 99.4% Example 117: Rl= cyclohexyl, R2= methyl, R3= 3-thienyl Cyclohexyl- (3-methyl-5-thiophen-3-yl-3H- [1,3,4] thiadiazol- 2 -ylidene) -amine To a solution of 1,3,4-thiadiazole 7c (0.75 mmol, 200 mg) in anhydrous dioxane (10 mL) , methyltrifluoromethane sulfonate (1.13 mmol, 128 μl) was added. The resultant mixture was stirred for 24 h. To this solution was added 0.225 mmol (26 μl) of methyltrifluoromethanesulfonate to allow reaction to completion, and 0.675 mmol (94 μl) of triethylamine. The mixture is concentrated by distillation under reduce pressure and the residue was dissolved in water. The aqueous mixture was then basified (pH= 5-6 ) with saturated NaHC0 3 solution with ethyl acetate. The organic layer was saturated with NaCl and dried over magnesium sulfate, filtered and distilled to give a residue which was purified by silica gel chromatography, eluting with cyclohexane containing from 0 to 15% AcOEt to provide 80 mg of the desired product. Yield : 38% X H-NMR (400MHz , DMSO): δ PPm= 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.7-1.8 (m, 4H) , 2.55-2.65 (m, IH) , 3.45 (a, 3H) , 7.40 (d, IH) , 7.70 (d, IH) , 7.85. (a, IH) . MS (m/z) / M+l= 280.23 HPLC (uv purity, λ= 214 nm) : 99.9% Example 117.1: Rl= cyclohexyl, R2= methyl, R3= 3, 5-dichloro- phenyl Cyclohexyl- [5- (3, 5-dichloro^phenyl) -3-methyl-3H~ [1,3,4] thiadiazol-2 -ylidene] -amine Compound 117.1 was prepared by the procedure described in example 117 using appropriate intermediates and reagents. Yield: 43% X H-NMR (400MHz , DMSO) δ PPm: 1.15-1.35 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.90 (m, 4H) , 2.55-2.65 (m, IH) , 3.50 (s, 3H) , 7.65 (s, 2H) , 7.70 (s, IH) MS (m/z) / M+l= 342.2 HPLC (uv purity, λ= 214 nm) : 99.9% Compound 117.2 was prepared by the procedure described in example 117 using appropriate intermediates and reagents. 117.2 Cyclohexyl- [5- (2-ethyl-5-methyl-2H-pyrazol-3-yl) -3- methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -amine Example 118: Rl= cyclohexyl, R2= methyl, R3= 3-chloro-2, 6- 7^ dimethoxyphenyl [5- (3-Chloro-2,6-dimethoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -cyclohexyl-amine To a solution of the 1,3,4-thiadiazole 7d (0.226 mmol, 80 mg) in anhydrous dioxane (10 mL) , methyltrifluoro methanesulfonate (0.27 mmol, 31 μl) was added. The resultant mixture was stirred for 24 h. To this solution was added 0.068mmol (7 μl) of methyltrifluoromethanesulfonate to allow reaction to completion. The mixture was concentrated by distillation under reduced pressure and the residue was dissolved in water. The aqueous mixture was then basified (pH= 5-6) with saturated NaHC0 3 solution and extracted with ethyl acetate. The organic layer was washed with saturated solution of NaCl and dried over magnesium sulfate, filtered and distilled to give a residue which was purified by silica gel chromatography. (eluent: cyclohexane/ethyl acetate, 80/20) . 11 mg of desired product was obtained. Yield: 13% X H-NMR (400MHz , DMSO) δ ppm: 1.15-1.40 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.80 (m, 4H) , 2.50-2.60 (m, IH) , 3.50 (s, 3H) , 3.75 (s, 3H) , 3.80 (a, 3H) , 7.00 (d, IH) , 7.60 '(d, IH) MS (m/z) / M+l= 368.26 HPLC (uv purity, λ= 214 nm) : 99.7% Compound 118.1 was prepared by the procedure described in example 118 using appropriate intermediates and reagents: 118.1 Cyclohexyl- (5-isoxazol-5-yl-3 -methyl-3H- [1,3,4] thiadiazol -2 -ylidene) -amine Example 118.2: Rl= cyclohexyl, R2= methyl, R3= 2- (5-pyridin- 2-yl) -thienyl Cyclohexyl- [3 -methyl-5- (5-pyridin-2-yl-thiophen-2-yl) -3H- [1,3,4] thiadiazol-2 -ylidene] -amine Compound 118.2 was prepared by the procedure described in example 118 using appropriate intermediates and reagents. The residue was purified by silica gel chromatography If eluting with a gradient of cyclohexane containing from 0 to 10% ethyl acetate. Yield: 57% X H-NMR (400MHz , DMSO) δ ppm: 1.15-1.35 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.80 (m, 4H) , 2.55-2.65 (m, IH) , 3.45 (s, 3H) , 7.30 (m, IH) , 7.35 (d, IH) , 7.80 (d, IH) , 7.85 (m, IH) , 7.95 (d, IH) , 8.55 (d, IH) . MS (m/z) / M+l= 357.3 HPLC (uv purity, λ= 214 nm) : 99.5% Example 18.3: Rl= cyclohexyl, R2= methyl, R3= 3 , 5-dihydroxy- 4-me hoxy-phenyl 5- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -2-methoxy-benzene-l,3-diol; compound with trifluoro- me hanesulfonic acid Compound 118.3 was prepared from the appropriate 1,3,4- thiadiazole 7 prepared by the procedure described in example 118. In this particular case, the mixture was concentrated and the formed precipitate was filtered and washed with ethyl acetate to give the expected compound as a salt of trifluoromethansulfonic acid. ' Yield: 45%- X H-NMR (400MHz , DMSO) δ Ppm: 1-1.40 (m, 5H) , 1.45-1.55 (m, IH) , 1.65-1.75 (m, 2H) , 1.85-1.95 (m, 2H) , 3.05-3.20 (m, lH) , 3.6 (s, 3H) , 4.00 (bs, 3H) , 6.65 (s, 2H) , 9.60 (bs, 2H) , 10.00 (bs, IH) . MS (m/z) / M+l= 336.4 HPLC (uv purity, χ= 214 nm) : 99.7% Example 118.4: Rl= cyclohexyl, R2= methyl, R3= 3 -hydroxy- 4, 5-dimethoxy-phenyl 5- (5-Cyσlohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -2, 3-dimethoxy-phenol; compound with trifluoro- methanesulfonic acid Compound 118.4 was prepared from the appropriate 1,3,4- thiadiazole 7 prepared by the procedure described example 118. In this particular case, the mixture was concentrated 7έ> and the formed precipitate was filtered and washed with ethyl acetate to give the expected compound as a salt of trifluoromethansulfonic acid. Yield: 11% 1H-NMR (400MHz , DMSO) δ pm: 1.10-1.50 (m, 5H) , 1.60-1.70 (m, IH) , 1.75-1.85 (m, 2H) , 1.95-2.10 (m, 2H) , 3.10-3.25 (m, IH) , 3.75 (s, 3H) , 3.85 (s, 6H) , 6.85 (s, IH) , 6.95 (s, IH) , 9.80 (bs, IH) , 9.90 (bs, IH) . MS (m/z) / M+l= 350.45 HPLC (uv purity, λ= 214 nm) : 99.9% Example 118.5: Rl= cyclohexyl, R2= methyl, R3= 4-chloro- phenyl [5- (4-Chloro-phenyl) -3 -methyl-3JT- [1,3,4] thiadiazol-2- ylidene] -cyclohexyl-amine Compound 118.5 was prepared by the procedure described in example 118 using appropriate intermediates and reagents. X H-NMR (400MHz , DMSO) δ ppm: 1.20-1.40 (m, 5H) , 1.57-1.63 (m, IH) , 1.70-1.82 (m, 4H) , 2.60 (br, IH) , 3.50 (s, 3H) , 7.52 (d, 2H) , 7.65 (d, 2H) . MS (m/z) / M+l= 308/310 .. _1 HPLC (uv putrity, χ= 214nm) : 94.24% Example 118.6: Rl= cyclohexyl, R2= methyl, R3= 3-chloro-4- hydroxy-5-methoxy-phenyl 2-Chloro-4- (5-cyclohexylimino-4-methy1-4,5-dihydro- [1,3,4] thiadiazol-2 -yl) -6-methoxy-phenol; compound with 1, 1, 1-trifluoro-methanesulfonic acid Compound 118.6 was prepared from the appropriate 1,3,4- thiadiazole 7i.To a solution of intermediate 7i (2 mmol, 675 mg) in anhydrous dioxane (10 mL) , methyltrifluoromethane sulfonate (3 mmol, 337 μl) was added. The resultant mixture was stirred for 48 h to give a precipitate. The mixture was filtered and washed with ethyl acetate to give 400 mg of desired product as a salt of trifluoromethanesulfonic acid. Yield: 40% X H-NMR (400MHz , DMSO) δ ppπi: 1.15-1.55 (m, 5H) , 1.60-1.70 (m, IH) , 1.76-1.88 (m, 2H) , 2.00-2.11 (m, 2H) , 3.11-3.25 (m, IH) , 3.85 (s, 3H) , 3.95 (a, 3H) , 7.30 (s, IH) , 7.48 (a, IH) , 9.90 (s, IH) , 10.50 (s, IH) . MS (m/z) / M+l= 354/356 HPLC (uv purity, λ= 214 nm) : 99.4% Example 119: Rl= cyclohexyl, R2= methyl, R3= 4-chloro-3- sulfamoyl-phenyl 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide To a solution of 1,3,4-thiadiazole 7a (0.215 mmol, 80 mg) in anhydrous dioxane (10 mL) , methyltrifluoromethane sulfonate (0.257 mmol, 29 μl) was added. The resultant mixture was stirred for 24 h. To this solution was added (0.065 mmol, 7 μl) of methyltrifluoromethanesulfonate to allow reaction to completion. The filtrate is concentrated by distillation under reduced pressure and the residue was dissolved in water. The aqueous mixture was then basified (pH= 5-6) with saturated NaHC0 3 solution and extracted with ethyl acetate. The organic layer was washed with a saturated solution of NaCl and dried over magnesium sulfate, filtered and distilled to give a residue which was purified by silica gel chromatography. (eluted with a gradient of cyclohexane/ethyl acetate) to afford 59 mg of pure product. Yield: 71% X H-NMR (400MHz , DMSO) δ PPm: 1.25-1.55 (m, 5H) , 1.65-1.75 (m, IH) , 1.75-1.95 (m, 4H) , 2.70-2.80 (m, IH) , 3.65 (s, 3H) , 7.80-7.95 (m, 4H) , 8.30 (dd, IH) . MS (m/z) / M+l: 387.3 HPLC (uv purity, λ= 214 nm) : 99.7% Example 119.1: Rl= cyclohexyl, R2= methyl, R3= 4-chloro- N,N- diethyl-3 -sulfonamide-phenyl 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N,N-diethyl-benzenesulfonamide To a mixture of compound 119 (0.258 mmol, 0.100 g) , tetra-n- butylammonium hydrogen sulphate (0.0258 mmol, 0.090 g) , 50% aqueous sodium hydroxide (0.300 ml) and toluene (2.2 ml), was added ethylbromide (0.310 mmol, 0.023 ml). The reaction was stirred at RT for 2h and then heated to 90°C for lh30 before a second addition of ethylbromide (0.310 mmol, 0.023 ml) . The mixture was heated at 90°C for 2h30 and the volatiles were removed by distillation. The crude material was solubilized with ethyl acetate and the organic layer was washed with brine, dried over MgS0 and concentrated under reduced pressure to give 0.1 g of the expected product as a white solid. Yield= 87.7% X H-NMR (400MHz, DMSO) δ PP™: 1-00 (t, 6H) , 1.10-1.32 (b, 5H) , 1.48-1.54 (m, IH) , 1.65-1.73 (b, 4H) , 2.53-2.62 (b, IH) , 3.20-3.30 (m, 4H) , 3.48 (s, 3H) , 7.68-7.79 (m, 2H) , 8.11 (s, IH) . MS (m/z) / M+l= 443/445 HPLC (uv purity, λ= 214 nm) = 99.72% Example 119.2: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- (4- methyl-piperazine-1-sulfonyl) -phenyl {5- [4-Chloro-3- (4-methyl-piperazine-1-sulfonyl) -phenyl] -3- methyl-3H- [1,3,4] thiadiazol-2-ylidene}-cyclohexyl-amine To a solution of 119 (0.516 mmol, 0.2 g) in DMF (13 ml) were added potassium carbonate (1.548 mmol, 0.214 g) and water (3 ml) . The mixture was stirred at RT until obtaining an homogenous solution and then the bia- (2-chloro-ethyl) methyl- amine hydrochloride (0.516 mmol, 0.10 g) was added. After a day of stirring, the mixture was warmed at 80°C for 15h. The solvents were then evaporated and the crude material was solubilized in dicloromethane. The organic layer was washed with a satured solution of bicarbonate of sodium, then with brine. After fitration, the filtrate was dried over MgS0 4 and concentrated by distillation. The crude material was chromatographed on silica gel, eluting with dichloromethane containing from 0 to 5% methanol. The solid product was then washed with ethyl acetate . iq Yield= 10% X H-NMR (400MHz, CDCI3 + D 2 0) δ PPm: 1.20-1.48 (m, 5H) , 1.62- 1.68 (m, IH) , 1.79-1.89 (m, 4H) , 2.45 (s, 3H) , 2.45 (t, 4H) , 2.55-2.65 (m, IH) , 3.33 (t, 4H) , 3.60 (s, 3H) , 7.52 (d, IH) , 7.72 (d, IH) , 8.24 (s, IH) . MS (m/z) / M+l= 470 HPLC (uv purity, %- 214 run): 99.53% Example 119.3: Rl= cyclohexyl, R2= methyl, R3= 4-chloro-3- [ (pyridin-4-ylmethyl) -sulfamoyl] -phenyl 2-Chloro-5- (5-cyclohexylimino- -methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N-pyridin-4-ylmethyl- benzenesul onamide To a mixture of 119 (0.258 mmol, 0.1 g) , triethylamine (0.516 mmol, 0.072 ml) and acetic acid (0.516 mml, 0.03 ml) in 1,2- dichloroethane, 4-pyridine carboxaldehyde (0.387 mmol, 0.037 ml) was added. The mixture was cooled to 0°C and sodium triacetoxyborohydride (0.516 mmol, 0.135 g) was added. After 24h of stirring at RT the same quantities of borohydride and aldehyde were added and the reaction was stirred for 15h. The mixture was then filtered and the filtrate was diluted with dichloromethane, washed with water, brine, dried over MgS0 4 , filtered and then evaporated to dryness. The residue was purified on silica gel eluting with dichloromethane containing from 0 to 7% of methanol. The solid product was then washed with ether to give the title product. Yield= 40% X H-NMR (400MHz , DMSO) δ ppm: 1.15-1.39 (m, 5H) , 1.54-1.60 (m, IH) , 1.70-1.80 (m, 4H) , 2.60-2.67 (m, IH) , 3.50 (s, 3H) , 4.18 (s, 2H) , 7.22 (d, 2H) , 7.67 (dd, IH) , 7.76 (dd, IH) , 8.06 (d, IH) , 8.39 (d, 2H) , 8.73-8.78 (b, IH) . MS (m/z) / M+l= 478 HPLC (uv purity, λ= 214 nm) : 99.99% Example 19.4: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- (2- morpholin-4-yl-ethyl-sulfamoyl) -phenyl 2 -Chloro-5- (5-cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-morpholin-4-yl-ethyl) - go benzenesulfonamide 2-Chloro-iV- (2 -chloro-ethyl) -5- (5-cyclohexylimino-4-methyl- 4, 5-dihydro- [1, 3 , 4] thiadiazol-2 -yl) -benzenesulfonamide was prepared by the procedure described in example 119.3 using an appropriate aldehyde and 119. The residue was purified by silica gel chromatography eluting with a gradient cyclohexane containing from 0 to 20% of ethyl acetate followed by an isocratic elution with ethyl acetate/cyclohexane (4/6) . Yield= 84% To a mixture of this intermediate (0.866 mmol, 0.390 g) , in presence of sodium iodide in ethanol (10 ml) , morpholine (8.66 mmol, 0.756 ml) was added. After 15 h at reflux, the mixture was evapored to dryness and the crude material was basified with a saturated solution of sodium bicarbonate. After extraction with ethyl acetate, the organic layer was washed with brine, dried over MgS0 , filtered and then evaporated to dryness. The residue was • purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 50% of ethyl acetate. Yield= 65% X H-NMR (400MHz, CDC1 3 ) PPm: 1.20-1.50 (m, - 5H) , 1.61-1.69 (m, IH) , 1.80-1.89 (b, 4H) , 2.30-2.39 (m, 4H) , 2.41-2.49 (m, 2H) , 2.59-2.68 (m, IH) , 3.00-3.09 (m, 2H) , 3.60-3.73 (m, 7H) , 5.81-5.89 (b, IH) , 7.54 (d, IH) , 7.73 (d, IH) , 8.32- . ..(a, IH) . MS (m/z) / M+l= 500/501 HPLC (uv purity, λ= 214 nm) : 97.76% Example 119.5: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- ethylsulfamoyl-phenyl 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-benzenesulfonamide The title compound was prepared as described in example 119.3. In this particular case, a large excess of acetaldehyde (20 equivalents) and triacetoxy borohydride (4 equivalents) were used and added once. Yield= 50% X H-NMR (400MHz, CDC1 3 ) δ ppm: 1.13 (t, 3H) , 1.23-1.50 (m, 5H) , 1.61-1.68 (m, IH) , 1.78-1.87 (b, 4H) , 2.57-2.64 (m, IH) , 2.97-3.04 (q, 2H) , 3.60 (a, 3H) , 4.90 (t, IH) , 7.53 (d, IH) , 7.77 (d, IH) , 8.30 (s, IH) . MS (m/z) / M+l= 415/416 HPLC (uv purity, χ= 214 nm) : 99.36% Example 119.6: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- [ethyl- (2-morpholin-4-yl-ethyl) -sulfamoyl] -phenyl 2-Chloro-5- (5-cyclohexylimino-4-meth 1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- (2-morpholin-4-yl-ethyl) - benzenesulfonamide I To a mixture of 119.4 (0.100 mmol, 0.05 g) , N-tetrabutyl ammonium hydrogen sulfate (0.02 mmol, 0.008 g) , a solution of 50% of sodium hydroxide (1.25 mmol, 0.1 ml) in toluene (2 ml), ethylbromide (1 mmol, 0.075 ml) was added. The mixture was heated to 90°C for 5h and then evaporated to dryness. The residue was solubilized in ethyl acetate and the organic layer was washed with brine, dried over MgS0 4 , filtered and then distilled under vaccum. The crude material was purified on silica gel chromatography eluting with a mix " ture of ethylacetate/cyclohexane in a ratio 1/9 then 2/8 to give the expected product . Yield= 60% X H-NMR (400MHz, CDC1 3 ) δ ppm: 1.13 (t, 3H) , 1.22-1.45 (m, 5H) , 1.61-1.68 (m, IH) , 1.78-1.84 (b, 4H) , 2.38-2.43 (m, 4H) , 2.50-2.53 (t, 2H) , 2.57-2.64 (m, IH) , 3.40-3.50 (m, 4H) , 3.60-3.65 (m, 7H) , 7.50 (d, IH) , 7.70 (d, IH) , 8.30 (s, IH) . MS (m/z) / M+l = 528/529 HPLC (uv purity, λ= 214 nm) : 98.57% Example 119.7: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- [isopropyl- (2-morpholin-4-yl-ethyl) -sulfamoyl] -phenyl 2-Chloro-5- (5-cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N-isopropyl-N- (2-morpholin-4-yl- ethyl) -benzenesulfonamide The title compound was prepared as described in example 119.6 with 13 equivalents of isopropylbromide. The residue was purified by silica gel chromatography eluting with a gradient of cyclohexane containing from 0 to 20% ethylacetate. Yield= 74% X H-NMR (400MHz, CDCls) δ ppm: 1.50 (d, 6H) , 1.22-1.47 (m, 5H) , 1.61-1.68 (m, IH) , 1.78-1.83 (b, 4H) , 2.44-2.50 (m, 4H) , 2.57-2.63 (m, 3H) , 2.47-2.51 (t, 2H) , 3.60 (s, 3H) , 3.68- 3.70 (m, 4H) , 3.98-4.04 (m, IH) , 7.50 (d, IH) , 7.70 (d, IH) , 8.30 (s, IH) . MS (m/z) / M+l= 542/543 HPLC (uv purity, λ= 214 nm) : 96.86% Example 119.8: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3-^ {ethyl- [2- (2-methoxy-ethoxy) -ethyl] -sulfamoyl}-phenyl 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- [2- (2-methoxy-ethoxy) - , ethyl] -benzenesulfonamide To a solution of 119.5 (0.241 mmol, 0.1 g) in EtOH (4 ml), potassium carbonate (0.289 mmol, 0.040 g) was addedd and then the reaction mixture was heated at reflux for 30 min before the addition of l-bromo-2- (2-methoxyethoxy) ethane (0.289 mmol, 0.040 ml) . After 3h at reflux, 2.4 equivalents of the bromo derivative were added and the mixture was kept at reflux for additional 15h. The mixture was then evaporated to dryness and the residue was diluted in water and extracted with -dichloromethane. The organic layer was washed with water, brine, dried over MgS0 4 , filtered and evaporated to dryness. The crude material was purified by silica gel chromatography eluting with a gradient of cyclohexane containing from 10 to 60% ethylacetate. Yield= 64% X H-NMR (400MHz, CDCI3) δ PP™: LU (t, 3H) , 1.20-1.47 ( , 5H) , 1.61-1.68 (m, IH) , 1.79-1.89 (b, 4H) , 2.59-2.68 (m, IH) , 3.36 (s, 3H) , 3.43-3.50 (m, 4H) , 3.54-3.58 (m, 4H) , 3.61-3.65 (m, 5H) , 7.50 (d, IH) , 7.70 (d, IH) , 8.28 (s, IH) . MS (m/z) / M+l= 518/520 HPLC (uv purity, λ= 214 nm) : 99.9% Example 119.9: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- [ (3-dimethylamino-2-hydroxy-propyl) -ethyl-sulfamoyl] -phenyl C-Chloro- (cyclohexylimino-methy1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (dimethylamino-hydroxy-propyl) -N- ethyl-benzenesulfonamide An excess of epibromohydrin (3 molar equivalents) was reacted with 119.5 following the procedure described in example 119.8. The intermediate was isolated by chromatography on silica gel eluting with a mixture of cyclohexane/ethylacetate in a ratio 1/9. To a solution of this intermediate (0.106 mmol, 0.05 g) in EtOH (2 ml) at 50°C, dimethylamine (0.318 mmol, 0.041 ml) was added and the mixture was heated at 70°C for 15h. The solvent was then removed under reduced pressure. The residue was diluted in water and extracted with dichloromethane. The organic layer was washed with water, brine, dried over MgS0 4 , filtered and the volatile was evaporated to give the desired product . Yield= 64% X H-NMR (400MHz, CDC1 3 ) δ PPm: 1.10 (t , 3H) , 1.22-1.49 (m, 5H) , 1.60-1.70 (m, IH) , 1.79-1.89 (b, 4H) , 2.254-2.36 (m, 8H) , 2.58-2.66 (m, IH) , 3.31-3.34 (dd, IH) , 3.42-3.6Q. (m, 6H) , 3.79-3.87 (m, IH) , 7.50 (d, IH) , 7.70 (d, IH) , 8.30 (s, IH) . MS (m/z) / M+l= 516/517 HPLC (uv purity, χ= 214 nm) : 96.60% Example 119.10: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- [ (2,3-dihydroxy-propyl) -ethyl-sulfamoyl] -phenyl 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2,3-dihydroxy-propyl) -N-ethyl- benzenesulfonamide The title compound was prepared as described in example 119.8 with 3 eq. of 3-bromo-l, 2-propane-diol and the reaction mixture was heated at reflux for' 12h. The desired product was obtained after purification of the crude material by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 3% methanol. Yield= 38% X H-NMR (400MHz, CDC1 3 ) δ Ppm: 1.10 (t, 3H) , 1.22-1.49 (m, 5H) , 1.62-1.68 (m, IH) , 1.79-1.89 (m, 4H) , 2.17-2.22 (m, IH) , 2.59-2.66 (m, 2H) , 3.40-3.48 (m, 3H) , 3.51-3.57 (dd, IH) , 3.61 (s, 3H) , 3.89-3.94 (m, IH) , 7.53 (d, IH) , 7.73 (d, IH) , 8.30 (s, IH) . MS (m/z) / M+l= 489/490 HPLC (uv purity, λ= 214 nm) : 98.41% Example 119.11: Rl=s cyclohexyl, R2= methyl, R3= 4-Chloro-3- [ethyl- (2-hydroxy-3-pyrrolidin-l-yl-propyl) -sulfamoyl] - phenyl 2-Chloro-5- (5-cyclohexylimino-4-meth l-4,5-dihydro- [1,3,4] thiadiazol-2 -yl) -N-ethyl-N- (2-hydroxy-3-pyrrolidin-l- yl-propyl) -benzenesulfonamide The title compound was prepared as described in example 119.9 using the same intermediate and pyrrolidine (3eq) as nucleophile. The residue was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 2 to 3% of methanol. Yield= 27% X H-NMR (400MHz, CDCI3) δ ppm: 1.10 (t, 3H) , 1.19-1.47 (m, 5H) , 1.64-1.70 (m, IH) , 1.77-1.90 (m, 4H) , 2.48-2.51 (dd, IH) , 2.53-2.78 (m, 7H) , 3.33-3.37 (dd, IH) , 3.45-3.54 (m, 2H) , 3.56 (d, 2H) , 3.61 (a, 3H) , 3.87-3.95 (m, IH) , 7.51 (d, IH) , 7.72 (d, IH) , 8.30 (a, IH) . MS (m/z) / M+l= 542/543 HPLC (uv purity, = 214 nm) : 95.50% Example 119.12: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- [ (2-diethylamino-ethyl) -ethyl-sulfamoyl] -phenyl 2-Chloro-5- (cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -N- (2-diethylamino-ethyl) -N-ethyl- benzenesulfonamide The title compound was prepared as described in example 119.8 using 3.3 eq of potassium carbonate and 2eq of 2- diethylaminoethylchloride hydrochloride . The residue was purified by silica gel chromatography eluting with a mixture ST of MeOH/DCM (10/90) . Yield= 32% X H-NMR (400MHz, CDC13) δ Ppm: LOO (t, 6H) , 1.17 (t, 3H) , 1.22-1.48 (m, 5H) , 1.61-1.70 (b, IH) , 1.80-1.90 (m, 4H) , 2.48-2.53 (q, 4H) , 2.59-2.63 (m, 3H) , 3.40-3.45 (m, 4H) , 3.63 (s, 3H) , 7.50 (d, IH) , 7.72 (d, IH) , 8.30 (s, IH) . MS (m/z) / M+l= 514/ 515 HPLC (uv purity, λ= 214 nm) : 99.34% Example 119.13: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro-3- [ (2 -dimethylamino-1-methyl-ethyl) -ethyl-sulfamoyl] -phenyl 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -N- (2-dimethylamino-methyl-ethyl) -N- ethyl-benzenesulfonamide (minor isomer) and Example 119.14: Rl= cyclohexyl, R2= methyl, R3= 4-Chloro- 3- [ (2-dimethylamino-propyl) -ethyl-sulfamoyl] -phenyl 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-dimethylamino-propyl) -N-ethyl- benzenesulfonamide (major isomer) The title compounds were prepared by the procedure described in example 119.8 using 3.3 eq of potassium carbonate and 2eq of the of 2-dimethylaminoisopropylchloride hydrochloride . Two "isomers" were obtained from this reaction: The crude material was purified by silica gel chromatography eluting with dichloromethane/methanol (99/1) to afford two isomers. The minor isomer: Yield= 10% X H-NMR (400MHz, CDC1 3 ) δ PPm: 1.20-1.47 (m, 11H) , 1.64-1.72 (m, IH) , 1.77-1.86 (m, 4H) , 2.10 (s, 6H) , 2.23-2.36 (m, 2H) , 2.54-2.66 (m, IH) , 3.31-3.39 (m, IH) , 3.42-3.52 (m, IH) , 3.59 (s, 3H) , 3.88-3.93 (m, IH) , 7.50 (d, IH) , 7.70 (d, H) , 8.30 (s, IH) . MS (m/z) / M+l= 500/ 501 HPLC (uv purity, λ= 214 nm) : 98.67% The major isomer: Yield= 30% X H-NMR (400MHz, CDC1 3 ) δ PP™: 0.92 (d, 3H) , 1.11 (t, 3H) , 1.23-1.50 (m, 5H) , 1.62-1.70 (m, IH) , 1.79-1.89 (m, 4H) , 2.14 (s, 6H) , 2.59-2.64 (m, IH) , 2.77-2.86 (m, IH) , 3.33- 3.51 (m, 4H) , 3.59 (s, 3H) , 7.50 (d, IH) , 7.70 (d, H) , 8.30 (s, IH) . MS (m/z) / M+l= 500/ 501 HPLC (uv purity, χ= 214 nm) : 99.67% Example 120: Rl= cyclohexyl, R2= methylacetate, R3= 4- chlorophenyl [5- (4-Chloro-phenyl) -2-cyclohexylimino- [1,3,4] thiadiazol-3- yl] -acetic acid methyl ester To a solution of the appropriate 1,3,4-thiadiazole 7h (0.34 mmol, 100 mg) in anhydrous dioxane (3mL) , an excess of methyl bromoacetate (3.4 mmol) was added. The resultant mixture was stirred for 48 h at 90°C The mixture was concentrated and a saturated solution of K 2 CO 3 was added. The solution was extracted with ethylacetate, the organic layer was dried over MgS0 4 , filtered and concentrated to dryness. The residue was purified by chromatograpy on silica gel using a gradient of solvent cyclohexane/ethylacetate to afford 66 mg of product. Yield= 52% X H-NMR (400MHz, DMSO) δ PP™: 1.20-1.35 (m, 5H) , 1.55-1.60 (m, IH) , 1.65-1.75 (m, 4H) , 2.65 (br, IH) , 3.65 (s, 3H) , 4.77 (s, 2H) , 7.53 (d, 2H) , 7.67 (d, 2H) . MS (m/z) / M+l= 366/368 HPLC (uv putrity,λ= 214nm) : 99.70% The compounds of the following examples were prepared by the procedure described in example 120 using appropriate intermediates and reagents: 120.1 [5- (4-Chloro-phenyl) -3-cyclopropylmethyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine 120.2 3- [5- (4-Chloro-phenyl) -2-cyclohexylimino- & [1,3,4] thiadiazol-3-yl] -propane-1, 2-diol 120.3 [5- (4 -Chloro-phenyl) -3- (2-diethylamino-ethyl) -3H- [1,3,4] thiadiazol-2 -ylidene] -cyclohexyl-amine Example 121: Rl= cyclohexyl, R2= methyl, R3= 3- benzoic acid methyl ester 3- (5-Cyclohexylimino-4-methy1-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzoic acid methyl ester To a solution of the appropriate 1,3,4-thiadiazole 7 (1.86 mmol, 590 mg) prepared by the procedure described in example 7g in anhydrous dioxane (20 mL) , methyltrifluoromethane sulfonate (2.79 mmol, 316 μl) and triethylamine (2.23 mmol, 310 μl) were added. The mixture was stirred for 7h at RT. The mixture was filtered and the precipitate was then poured into diluted NaHC0 3 solution and washed with dichloromethane. The organic layer was washed with saturated solution of NaCl and dried over magnesium sulfate, filtered and concentrated under reduce pressure to give 200 mg of the title product. Yield: 37% X H-NMR (400MHz , DMSO) δ PP™: 1.10-1.35 (m, 5H), ' 1.45-1.55 (m, IH) , 1.60-1.75 (m, 4H) , 2.50-2.60 (m, IH) , 3.45 (s, 3H) , 3.80 (s, 3H) , 7.55 (t, IH) , 7.80 (d, 2H) , 7.95 (d, 2H) , 8.10 (s, IH) . MS (m/z) / M+l= 332.3 HPLC (uv purity, λ= 214 nm) : 99.9% Example 121.1: Rl= cyclohexyl, R2= methyl, R3= 3 -benzoic acid 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzoic acid To . a solution of compound 121 (30 mg, 0.09 mmol) in methanol (10 ml) and water (2.5 ml), K 2 C0 3 (163 mg,1.17 mmol) was added. The mixture was heated at reflux for 3h, allowed to cool and concentrated in vacuo to give a crude material . This residue was poured into water and the suspension was carefully neutralised with a solution of HC1 (0.1N) and the aqueous phase was extracted with ethyl acetate. The organic layer was washed with saturated solution of NaCl, dried over • magnesium sulfate, filtered and distilled to give 10 mg of the title product . Yield: 35% H-NMR (400MHz, DMSO) δ ppm: 1.15-1.40 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.80 (m, 4H) , 2.55-2.65 (m, IH) , 3.50 (s, 3H) , 7.55 (t, IH) , 7.80 (d, IH) , 7.95 (d, IH) , 8.15 (a, IH) , 13.3 (bs, IH) . MS (m/z) / M+l= 318.3 HPLC (uv purity, χ= 214 nm) : 99.6% Example 121.2: Rl= cyclohexyl, R2= methyl, R3= 3-benzamide 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzamide To a solution of LiOH monohydrate (96 mg, 2.26 mmol) in 1.6 ml of water, a solution of 121 (500 mg, 1.51 mmol) in tetrahydrofuran (THF) /MeOH (50/50) (8 ml) was added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water and a solution of HCl (0.1N, 38 ml) was added. 'The resulting mixture was stirred for 2 hours. After distillation of water , the product was dried over P0 5 in vacuo. To a solution of this crude material (1.51 mmol) in toluene (10 ml), thionylchloride (10 ml) was added dropwise and the mixture was heated at reflux for 5H. The mixture was concentrated under reduced pressure. A solution of ammonia (1 ml at 28%) was added to a solution of the residue (150 mg, 0.32 mmol) in THF (2 ml) cooled to 10°C After 3 hours at RT, the mixture was concentrated to dryness,. poured into water and extracted with ethyl acetate. The combined organic extracts were washed with water and with a saturated solution of NaCl, dried over magnesium sulfate, filtered and distilled under reduced pressure. The white solid material was purified by silica gel chromatography (eluted with dichloromethane/methanol at 99/1) to afford 14mg of the title product. Yield: 14% ' X H-NMR (400MHz, DMSO) δ PPm: 1.20-1.45 (m, 5H) , 1.60-1.70 (m, IH) , 1.75-1.90 (m, 4H) , 2.65-2.75 (m, IH) , 3.60 (s, 3H) , 7.52 (s, IH) , . 7.60 (dd, IH) , 7.85 (d, IH) , 7.98 (d, IH) , 8.15(S, IH) , 8.18 (s, IH) . 5 MS (m/z) / M+l= 317 HPLC (uv purity, λ= 214 nm) : 99.9% Example 121.3: Rl= cyclohexyl, R2= methyl, R3= 3-[N-(2- hydroxy-ethyl) ] -benzamide 0 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N- (2 -hydroxy-ethyl) -benzamide To a solution of LiOH monohydrate (96 mg, 2.26 mmol) in 1.6 ml of ■ water, a solution of 121 (500 mg, 1.51 mmol) in THF/MeOH (50/50) (8 ml) was added. The mixture was stirred 5 at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water and a solution of HCl (0.1N, 38 ml) was added. The resulting mixture was stirred for 2 hours. After distillation of water , the product was dried over P 2 O s in vacuo. To a solution of this crude 0 material (1.51 mmol) in toluene (10 ml), thionylchloride (10 ml) was added dropwise and the mixture was heated at reflux for 5H. The mixture was concentrated under reduced pressure. To a suspension of this residue (150 mg, 0.32 mmol) in THF (2ml) with triethylamine (90 μl, 0.64 mmol) was added at ' 0°C 5 ethanolamine (20 μl, 0.32 mmol) and stirred at room temperature during 4 hours . Water was added in the mixture and extracted with ethyl acetate, washed with water and brine, dried with magnesium sulfate, filtred and reduce under pressure vacuum. The residue was purified by silica 0 gel chromatography with a gradient of dichlorometane containig from 0 to 2% methanol to afford 50 mg of the good product . Yield: 43% 1H-NMR (400MHz, DMSO) δ P ™: 1.15-1.35 (m, 5H) , 1.55-1.65 5 (m, IH) , 1.70-1.83 (m, 4H) , 2.55-2.75 (m, IH) , 3.30-3.37 (m, 2H) , 3.45-3.55 (m, 5H) , 4.70 (t, IH) , 7.55(dd, IH) , 7.80 (d, IH) , 7.90 (d, IH) , 8.05 (s, IH) , 8.60 (t, IH) . MS (m/z) / M+l= 361 HPLC (uv purity, λ= 214 nm) : 99.7% Example 121.4: Rl= cyclohexyl, R2= methyl, R3= 3- (N-methyl) - benzamide 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol- 2-yl) -N-methyl-benzamide To a solution of LiOH monohydrate (96 mg, 2.26 mmol) in 1.6 ml of water, a solution of 121 (500 mg, 1.51 mmol) in THF/MeOH (50/50) (8 ml) was added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in. water and a solution of HC1 (0.1N, 38 ml) was added. The resulting mixture was stirred for 2 hours. After distillation of water , the product was dried over P2O5 in vacuo. To a solution of this crude material (1.51 mmol) in toluene (10 ml), thionylchloride (10 ml) was added dropwise and the mixture was heated at reflux for 5H. The mixture was concentrated under reduced pressure. To a suspension of this residue (150 mg, 0.32- mmol) in THF (4 ml) with triethylamine (90 μl, 0.64 mmol) was added at 0°C methylamine hydrochloride (44 mg, 0.64 mmol) and stirred at room temperature during 4 hours . Water was added in the mixture and basified with a solution of NaHC0 3 , extracted with ethyl acetate, washed with water and brine, dried with magnesium sulfate, filtred and reduce under pressure vacuum. The residue was purified by silica gel chromatography with a gradient of dichlorometane containig from 0 to 2% methanol to afford the desired product. Yield: 9% X H-NMR (400MHz , DMSO) δ Pm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.70 (m, IH) , 2.82 (s, 3H) , 3.55 (S, 3H) , 7.60(t, IH) , 7.80 (d, IH) , 7.90 (d, IH) , 8.05(s, IH) , 8.55-8.65 (m, IH) . MS (m/z) / M+l= 331 HPLC (uv purity, λ= 214 nm) : 96.6% Example 122: Rl= cyclohexyl, R2= methyl, R3= 3,4- dihydroxyphenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzene-1, 2-diol; compound with trifluoro methanesulfonic acid Compound 122 was prepared from 1,3,4-thiadiazole 7g by the procedure described in example 118 using appropriate intermediates and reagents (protocol C) . In this particular case, the mixture was filtered and the precipitate was washed with dioxane and diethylether to give the expected compound as a trifluoromethanesulfonic acid salt. Yield= 54.1% X H-NMR (400MHz, DMSO) δ PP™: 1.10-1.53 (m, 5H) , 1.64-1.69 (b, IH) , 1.78-1.84 (b, IH) , 2.03-2.10 (b, 2H) , 3.19-3.27 (b, IH) , 3.84 (s, 3H) , 6.90 (d, IH) , 7.13 (d, IH) , 7.20 (a, IH) , 9.55-9.63 (b, IH) , 9.75-9.81 (b, IH) , 9.96-10.3( b, IH) . MS (m/z) / M+l= 306/307 HPLC (uv purity, λ= 214 nm) = 97.35 % Example 123: Rl= cyclohexyl, R2= methyl, R3= 3,-5-dimethoxy- 4-hydroxy-phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -2, 6-dimethoxy-phenol Compound 123 was prepared from the appropriate 1,3,4- thiadiazole 7 by the procedure described in example 118 using appropriate intermediates and reagents (protocol C) . In this particular case, the mixture was filtered and the precipitate was washed with dioxane and diethylether to give the expected compound as a trifluoromethansulfonic acid salt. Yield= 13.9% X H-NMR (400MHz, DMSO) δ PPm: 1.12-1.27 (b, IH) , 1.27-1.41 (b, 2H) , 1.41-1.54 (b, 2H) , 1.63-1.70 (b, IH) , 1.80-1.87 (b, 2H) , 2.03-2.11 (b, 2H) , 3.17-3.26 (b, IH) , 3.88 (9H, a) , 7.06 (a, 2H) , 9.38-9.47 (b, IH) , 9.80-9.88 (b, IH) . MS (m/z) / M+l= 350/351 HPLC (uv purity, λ= 214 nm) = 96.00% Compounds 123.1 and 123.2 were prepared by the procedure described in example 118 using appropriate intermediates and 5 reagents (protocol C) . 123.1 6- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -pyridin-2-ol 123.2 5- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3 , 4] thiadiazol-2 -yl) -benzene-1, 2 , 3-triol Example 124: Rl= cyclohexyl, R2= methyl, R3= 8- hyd oxyquino1in-2 -y1 " 10 2- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -quinolin-8-ol Compound 124 was prepared from the appropriate 1,3,4- thiadiazole 7 (procedure described in example 7d) by the procedure described in example 118.6. In this particular 15 case, the mixture was filtered and the precipitate was washed with dioxane and diethylether to give the expected compound as a trifluoromethansulfonic acid salt--. Yield =58.1% X H-NMR (400MHz, DMSO) δ ppm: 1.25-1.36 (b, IH) , 1.45-1.67 (b, 20 4H) , 1.74-1.81 (b, IH) , 1.90-1.96 (b, 2H) , 2.18-2.22 (b, ' • 2H) , 3.40-3.50 (b, IH) , 4.02 (s, 3H) , 7.35 (d, IH) , 7.63 (d, IH) , 7.69 (t, IH) , 8.21 (d, IH) , 8.64 (d, IH) , 10.08-10.13 (b, IH) , 10.21-10.28 (b, IH) . MS (m/z) / M+l= 341/342 25 HPLC (uv purity, λ= 214 nm) = 94.88% Example 125: Rl= cyclohexyl, R2= methyl, R3= 2-pyrazyl Cyclohexyl- (3-methyl-5-pyrazin-2-yl-3H- [1,3,4] thiadiazol-2- ylidene) -amine 30 The 1,3,4-thiadiazole 7f (0.770 mmol, 0.200 g) and methyltrifluoromethane sulfonate (0.924 mmol, 0.104 ml) ' ere reacted in dioxane (7 ml) . The residue, obtained after basification to pH 9-10 with a saturated solution of carbonate of potassium, was subjected to silica gel chromatography, eluting with dichloromethane containing from 0 to 10% methanol to give the expected product. Yield= 0.075g, 35.37% X H-NMR (400MHz, DMSO) δ pm: 1.20-1.43 (b, 5H) , 1.56-1.65 (b, IH) , 1.90-2.00 (b, 4H) , 2.63-2.70 (b, IH) , 3.56 (s, 3H) , 8.67 (s, 2H) , 9.12 (s, IH) . HPLC (uv purity, λ= 214 nm) = 98.32% MS (m/z) / M+l= 276/277 Example 126: Rl :=cyclohexyl, R2= methyl, R3= (E)-2-(3- hydroxy-4-methoxy-phenyl) -vinyl 5- [ (E) -2- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -vinyl] -2-methoxy-phenol Compounds 126 was prepared by the procedure described in example 118 using appropriate intermediate (1,3,4- thiadiazole 7 - procedure described in example 7d) and reagents.The desired product was isolated by chromatography on silica gel eluting with dichloromethane containing from 0 to 7% methanol. Yield= 0.025g, 24.1% X H-NMR (400MHz, DMSO) § ppra: 1.10-1.36 (b, 6H) , 1.52-1.59 (b, IH) , 1.66-1.78 (b, 4H) , 3.39 (s, 3H) , 3.76 (s, 3H) , 6.70-6.80 (b, IH) , 6.85-6.97 (b, 2H) , 6.97-7.07 (b, 2H) 9.04 (s, IH) . MS (m/z) / M+l= 346/347 HPLC (uv purity, χ= 214 nm) = 98.64% Example 127: Rl= cyclohexyl, R2= methyl, R3= 3-methoxy-4- hydroxy-phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl)-2-methox -pheno1 Compounds 127 was prepared by the procedure described in example 118 using appropriate intermediate (1,3,4- thiadiazole 7 - procedure described in example 7d) and reagents. The desired product was isolated by chromatography on silica gel (Alltech, 2g silice) eluting with cyclohexane containing from 0 to 4% ethylacetate. Yield= 0.015 g, 14.2% X H-NMR (400MHz, DMSO) δ ppm: 1.01-1.20 (b, 5H) , 1.39-1.44 (b, IH) , 1.53-1.63 (b, 4H) , 2.4-2.48 (b, IH) , 3.30 (s, 3H) , 3.65 (s, 3H) , 6.64 (d, IH) , 6.87 (d, IH) , 7.00 (d, IH) , 9.38-9.43 (b, IH) . MS (m/z) / M+l= 320/321 HPLC (uv purity, λ= 214 nm) = 99.08% Example 128: Rl= cyclohexyl, R2= methyl, R3= quinolin-8-yl Cyclohexyl- (3-methyl-5-quinolin-8-yl-3H- [1, 3,4] thiadiazol-2- ylidene) -amine Compounds 128 was prepared by the procedure described in example 118 using appropriate intermediate (1,3,4- thiadiazole 7 - procedure described in example 7b) and reagents. The residue was subjected to silica gel chromatography, eluting with cyclohexane containing from 0 to 20% AcOEt. Yield: 41% X H-NMR (400MHz, DMSO) δ ppm: 1.10-1.35 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.80 (m, 4H) , 2.70-2.80 (m, 1H),3.45 Cs, 3H) , 7.55- 7.60 (m, IH) , 7.60-7.70 (m, IH) , 7.95-8.05 (m, IH) , 8.35-8.40 (m, IH) , 8.40-8.45 (m, IH) , 8.20-8.80 ( , IH) . MS (m/z) / M+l= 325.3 HPLC (uv purity, λ= 214 nm) : 99 . 9% Example 129: Rl= cyclohexyl, R2= methyl, R3= 4-dimethy1amino- phenyl [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -phenyl] -dimethyl-amine Compounds 129 was prepared by the procedure described in example 118 using appropriate intermediate (1,3,4- thiadiazole 7 - procedure described in example 7b) and reagents. The product was chromatographed on silica gel column using cyclohexane/ethyl acetate with a ratio 8/2 as solvent . Yield: 27% X H-NMR (400MHz, DMSO) δ ppm: 1.10-1.35 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.80 (m, 4H) , 2.50-2.60 (m, IH) , 3.45 (s, 3H) , 6.70 (d, 2H) , 7.40 (d, 2H) . MS (m/z) / M+l= 317.3 HPLC (uv purity, λ= 214 nm) : 99.5% Example 130: Rl= cyclohexyl, R2= methyl, R3= 4-sulfonamide- phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2 -yl) -benzenesulfonamide Compounds 130 was prepared by the procedure described in example 118 using appropriate intermediate (1,3,4- thiadiazole 7 - procedure described in example 7b) and reagents . The residue was subjected to silica gel chromatography, eluting with cyclohexane containing from 0 to 20% AcOEt. Yield: 21% X H-N R (400MHz, DMSO) δ PPtn: 1.10-1.35 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.75 (m, 4H) , 2.50-2.60 (m, " IH) , 3.45 (s, 3H) , 7.40 (s, 2H) , 7.75 (d, 2H) , 7.85 (d, 2H) . MS (m/z) / M+l= 353.2 ι HPLC (uv purity, λ= 214 nm) : 98.5% Example 131: Rl= cyclohexyl, R2= methyl, R3= 5-chloroindol-2- yl [5- (5-Chloro-lH-indol-2-yl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylidene] -cyclohexyl-amine; compound with trifluoromethanesulfonic acid Compounds 131 was prepared by the procedure described in example 118.6 using appropriate intermediate (1,3,4- thiadiazole 7 - procedure described in example 7b) and reagents. In this particular case, the mixture was filtered and the precipitate was washed with ethyl acetate to give the expected compound as a salt of trifluoromethansulfonic acid. Yield: 88% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.55 (m, 5H) , 1.60-1.70 (m, IH) , 1.75-1.85 ( , 2H) , 1.95-2.10 (m, 2H) , 3.10-3.30 (m, IH) , 3.85 (bs, 3H) , 7.10-7.15 (m, IH) , 7.15-7.20 (m, IH) , 7.40-7.50 (m, IH) , 7.75 (bs, IH) , 10 (bs, IH) , 12.40 (bs, IH) . MS (m/z) / M+l= 347.3 HPLC (uv purity, λ= 214 nm) : 95.2% Compound 131.1 was prepared by the procedure described in example 131 using appropriate intermediates and reagents: 131.1 2- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol-2-yl) -phenol; compound with 1,1,1- trifluoro-methanesulfonic acid Example 132: Rl= cyclohexyl, R2= methyl, R3= 3-hydroxy-4- methoxy-phenyl 5- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -2-methoxy-phenol; compound with 1, 1, 1-trifluoro- methanesulfonic acid Compounds 132 was prepared by the procedure .. described in example 118.6 using appropriate intermediate (1,3,4- thiadiazole 7 - procedure described in example 7b) and reagents . In this particular case, the mixture was concentrated, filtered and the precipitate was washed with ethyl acetate to give the expected compound as a salt of trifluoromethansulfonic acid. Yield: 69% X H-NMR (400MHz, DMSO) δ ppm: 1.05-1.45 (m, 5H) , 1.50-1.60 (m, IH) , 1.70-1.80 (m, 2H) , 1.90-2.05 (m, 2H) , 3.05-3.20 (m, IH) , 3.8 (2s, 6H) , 7.00 (d, IH) , 7.15-7.20 (m, 2H) , 9.60 (bs, IH) , 9.75 (bs, IH) . MS (m/z) / M+l= 320.3 HPLC (uv purity, χ= 214 nm) : 98% Example 133: 4-hydroxy-phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -phenol; compound with 1,1,1-trifluoro-methanesulfonic acid Compounds 133 was prepared by the procedure described in example 118.6 using appropriate intermediate (1,3,4- thiadiazole 7 - procedure described in example 7b) and reagents . In this particular case, the mixture was filtered and the precipitate was washed with ethyl acetate to give the expected compound as a salt of trifluoromethansulfonic acid. Yield: 95% X H-NMR (400MHz, DMSO) δ PP™: 1.05-1.45 (m, 5H) , 1.50-1.60 (m, IH) , 1.65 -1.75 (m, 2H) , 1.90-2.00 (m, 2H) , 3.30-3.40 (m, IH) , 3.75 (S, 3H) , 6.85 (d, 2H) , 7.60 (d, 2H) , 9.70 (bd, IH) , 10.25 (bd, IH) . MS (m/z) / M+l= 290.3 HPLC (uv purity, λ= 214 nm) : 95.6% Example 134: Rl= cyclohexyl, R2= methyl, R3= 3,4-dimethoxy- phenyl Cyclohexyl- [5- (3,4-dimethoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine Compound 134 was prepared from the appropriate 1,3,4- thiadiazole 7 by the procedure described in example 117 (protocol C) using appropriate intermediates and reagents. The desired product was isolated by chromatography on silica gel eluting with cyclohexane containing from 0 to 20% ethylacetate. Yield: 28% H-NMR (400MHz, DMSO) δ PPm: 1.15-1.30 ( , 5H) , 1.45-1.55 (m, IH) , 1.60-1.75 (m, 4H) , 2.45-2.60 (m, IH) , 3.40 (s, 3H) , 3.70 (2s, 6H) , 6.95 (d, IH) , 7.05 (d, IH) , 7.10 (s, IH) MS (m/z) / M+l= 334.3 HPLC (uv purity, χ= 214 nm) : 98.2% Example 135: Rl= cyclohexyl, R2= methyl, R3= 3-bromo-4- <\ methoxy-phenyl [5- (3-Bromo-4-methoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene] -cyclohexyl-amine Compound 135 was prepared from 1,3,4-thiadiazole 7e, by the procedure described in example 117 (protocol C) using appropriate intermediates and reagents. The desired product was isolated by chromatography on silica gel eluting with cyclohexane containing from 0 to 15% ethylacetate . Yield: 13% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.35 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.55-2.65 (m, IH) , 3.50 (s, 3H) , 3.90 (s, 3H) , 7.20 (d, IH) , 7.60 (d, IH) , 7.85 (s, IH) MS (m/z) / M+l= 384.2 HPLC (uv purity, λ= 214 nm) : 95% The compounds of the following examples were prepared by the procedure described in example 135 using appropriate intermediates and reagents : 135.1 Cyclohexyl- [5- (4-methoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -amine 135.2 Cyclohexyl- (3-methyl-5-phenyl-3H- [1, 3 ,4] thiadiazol-2- ylidene) -amine Example 136: Rl= cyclohexyl, R2= methyl, R3a= 3-hydroxy-phenyl 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -phenol Compound 136 waa prepared from the appropriate 1,3,4- thiadiazole 7 by the procedure described in example 117 (protocol C) , using appropriate intermediates and reagents. The product was chromatographed on silica gel column using a gradient of cyclohexane/ethyl acetate. Yield: 14% X H-NMR (400MHz , DMSO) δ ppm : 1.15-1.40 (m, 5H) , 1.55-1.65 (m,lH) , 1.70-1.85 (m,4H), 2.55-2.65 (m, IH) , 3.50 (s,3H) , 6.85 (d,lH) , 7.00-7.05 (m, 2H) , 7.25 (t,lH) , 9.75 (s,lH) MS (m/z) / M+l =290.29 HPLC (uv purity, λ= 214 nm) : 93.9% Example 137: Rl= cyclohexyl, R2= methyl, R3= 4-benzoic acid methyl ester 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzoic acid methyl ester Compound 137 was prepared from the approriate 1,3,4- thiadiazole 7 by the procedure described in example 117 (protocol C) using appropriate intermediates and reagents. The product was chromatographed on silica gel column using a gradient of cyclohexane/ethyl acetate. Yield: 47% X H-NMR (400MHz, DMSO) δ PP™: 1.10-1.35 (m, 5H) , 1.50-1.60 (m, IH) , 1.65-1.75 (m, 4H) , 2.50-2.65 (m, IH) , 3.50 (a, 3H) , 3.80 (a, 3H) , 7.70 (d, 2H) , 8.00 (d, 2H) . MS (m/z) / M+l= 332.3 HPLC (uv purity, λ= 214 nm) : 99.9% Example 137.1: Rl= cyclohexyl, R2= methyl, R3= 4-benzoic acid 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzoic acid To a solution of 1, 3, 4-thiadiazol 137 (80 mg,0.24 mmol> ■ in methanol (10 ml) and water (2.5 ml), K 2 C0 3 (434 mg,3.14 mmol) was added. The mixture was heated at 65°C during 3h then at RT over night. The solvent was removed by distillation under reduced pressure to give a crude material . This residue was poured into water, the suspension was carefully neutralised with a solution of HCl (0.1N) and the aqueous phase was extracted with dichloromethane. The organic layer was washed with saturated solution of NaCl, dried over magnesium sulfate, filtered and distilled to give 40 mg of the title product . Yield: 52% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.55-2.70 (m, IH) , 3.55 (s, 3H) , loG 7.75 (d, 2H) , 8.00 (d, 2H) , 13.15 (bs, IH) . MS (m/z) / M+l= 318.4 • HPLC (uv purity, λ= 214 nm) : 99.9% Example 137.2: Rl= cyclohexyl, R2= methyl, R3= 4-hydroxamic acid phenyl 4- (5-Cyclohexylimino- -methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N-hydroxy-benzamide To a solution of LiOH monohydrate (37 mg, 0.75 mmol) in 0.8 ml of water, a solution of compound 137 (250 mg, 0.75 mmol) in THF/MeOH (50/50) (4 ml) was added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water (2 ml) and a solution of HCl (0.1N, 15 ml) was added. The resulting mixture was stirred for 20 min. After distillation of water, the crude product was dried over P2O 5 in vacuo. To a solution of 75 mg (0.19 mmol) of this crude material in toluene (1 ml) , a drop of pyridine, and thionylchloride (70 μl) were added and reacted at reflux during 4H. The volatiles were removed under reduced pressure. To a solution of this residue in anhydrous THF, O- (tr-imethylsilyl) hydroxylamine (230 μl, 0.47 mmol) was added with molecular sieves (3A) and the reaction mixture was stirred for 18H at RT. After filtration, the filtrate was concentrated under reduced pressure and the residue was treated with a 1 M solution of HCl, stirred at RT and then basified with a solution of NaHC0 3 . The aqueous phase was extracted with dichloromethane. The organic layer was washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo. The title product was isolated by preparative HPLC on inverse phase (HYPERSYL C18) eluting with water containing from 5 to 95% acetonitrile during 20 ran. Yield: 12 mg, 20% X H-NMR (400MHz, DMSO) PP™: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.70 (m, IH) , 3.50 (s, 3H) , 7.65 (d, 2H) , 7.85 (d, 2H) . MS (m/z) / M+l= 333.2 HPLC (uv purity, χ= 214 nm) : 94.9% Example 137.3: Rl= cyclohexyl, R2= methyl, R3= 4-benzamide 4- (5-Cyclohexylimino-4-meth 1-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzamide To a solution of LiOH monohydrate (126 mg, 3.0 mmol) in 0.8 ml of water, a solution of 137 (l.Og, 3mmol) in THF/MeOH (50/50) (4 ml) was added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water (8 ml) and a solution of HCl (0.1N, 60 ml) was added. The resulting mixture was stirred for 20 min. After distillation of water ,the product was dried over P2O5 in vacuo. To a solution of 120 mg (0.3 mmol) of this crude material in 2 ml of toluene, thionylchloride (2 ml) waa added- dropwise and the mixture was heated at reflux for 4H. The mixture was concentrated under reduced pressure. A solution of ammonia (1 ml at 28%) was added to a solution of the residue in THF (2 ml) cooled to 10°C After allowing to stand 5 hours at RT, the mixture was concentrated to dryness, poured into water and extracted with ethyl acetate. The combined organic extracts were washed with water and with a saturated solution of NaCl, dried over magnesium sulfate, filtered and distilled under reduced pressure. The white solid material was purified by silica gel chromatography (eluted with dichloromethane) to afford 64mg of the title product. Yield: 67% X H-NMR (400MHz, DMSO) δ pm: 1.20-1.45 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.70 (m, IH) , 3.55 (s, 3H) , 7.45(bs, IH) , 7.75 (d, 2H) , 7.95 (d, 2H) , 8.05 (bs, IH) . MS (m/z) / M+l= 317.35 HPLC (uv purity, χ= 214 nm) : 99.3% Example 137.4: Rl= cyclohexyl, R2= methyl, R3= 4-N- (2H- tetrazol-5-yl) -benzamide 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol- 2-yl) -N- (2H-tetrazol-5-yl) -benzamide hydrochloride salt To a solution of LiOH monohydrate (187 mg, 4.5 mmol) in 0.8 ml of water ,a solution of compound 137 (250 mg, 0.75 mmol) in THF/MeOH (50/50) (4 ml) was added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water (2 ml) and a 0.1 M solution of HCl was added to reach pH 6-7. After distillation of water " , the crude material was dried over P 2 O5 in vacuo. Morpholine type resin (180 mg, 0.62 mmol) was added to a solution of 450 mg (0.62 mmol) of this crude material in 15ml of THF cooled to -15°C Then isobutylchloroformate (105 μl, 0.8mmol) was added and the mixture was stirred at -15°C for 1H30 before addition of a suspension of amino-lH-tetrazole (80 mg, 0.74 mmol) in THF (10 ml) . The reaction mixture was allowed to stand overnight at RT and the mixture was filtered over a silica gel. The filtrate was concentrated to dryness, and purified by preparative HPLC on inverse phase C18 (HYPERSYL) , eluting with water containing from 5 to 95% acetonitrile in 20 min to afford 10 mg of the title product . The t compound was treated with a solution of ethanol/HCl to give the corresponding hydrochloride salt. Yield: 4% X H-NMR (400MHz, DMSO) δ Ppm: 1.10-2.15 (m, 10H) , 3.10-3.30 (m, IH) , 4.00 (bs, 3H) , 8.10 (bd, 2H) , 8.35 (bd, 2H) , 12.70' (bs, IH) . MS (m/z) / M+l= 385.46 HPLC (uv purity, χ= 214 nm) : 99.9% Example 137.5: Rl= cyclohexyl, R2= methyl, R3= 4-(N- quinolin-8-yl) -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N-quinolin-8-yl-benzamide To a solution of LiOH■ monohydrate (794 mg, 19mmol) in 18 ml of water, a solution of 137 (5.7 g, 17.2mmol) in THF/MeOH (50/50) (100 ml) was added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water and a solution of HCl (0.1N, 361 ml) was added. The resulting mixture was stirred for 3H30. After distillation of water, the crude product was dried over P 2 0 5 in vacuo. To a suspension of 200 mg (0.5 mmol) of this crude material in CH 2 C1 2 /DMF (50/50) (6 ml) were added cyclocarbodiimide-N-methyl resin (1.03 g, 1.5 mmol), 1-hydroxy-7-azabenzotriazol (14 mg, O.lmmol), N,Ndiisopropylethylamine (175 μl, 1 mmol) , 8-aminoquinoline (145 mg, 1 mmol) , molecular sieves (3A) and the reaction mixture was stirred 24H at RT. After filtration, methylisocyanate resin (1 g, 1 mmol) was added to the filtrate and the mixture was stirred for another 24H at RT. The mixture was filtered, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography eluting with a gradient of cyclohexane containing from 0 to 20% ethyl acetate to afford 10 mg of the title product. Yield: 4.5% X H-NMR (400MHz , DMSO) δ PPm: 1.20-1.40 (m, 5H) , 1.60-1.65 ( , IH) , 1.75-1.85 (m, 4H) , 2.65-2.75 (m, IH) , β.55 (s, 3H) , 7.65-7.75 (m, 2H) , 7.80 (d, IH) , 7.90 (d, 2H) , 8.15 (d, 2H) , 8.5 (d, IH) , 8.75 (d, IH) , 9.00 (d, IH) , 10.70 (s, IH) ' . MS (m/z) / M+l= 444.13 HPLC (uv purity, λ= 214 nm) : 96.4% Example 137.6: Rl= cyclohexyl, R2= methyl, R3= 4-N-(2,6- dimethoxy-pyridin-3 -yl) -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N- (2,6-dimethoxy-pyridin-3-yl) -benzamide To a solution of LiOH monohydrate (794 mg, 19 mmol) in 18 ml of water, a solution of 137 (5.7 g, 17.2 mmol) in THF/MeOH (50/50) (100 ml) was " added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water and a solution of HCl (0.1N, 361 ml) was added. The resulting mixture was stirred for 3H30. After distillation of water, the crude product was dried over P 2 Os in vacuo. To a suspension of 200 mg (0.5 mmol) of this crude material in CH 2 C1 2 /DMF (50/50) (6 ml) were added cyclocarbodiimide-N-methyl resin (1.03 g, 1.5 mmol), l-hydroxy-7-azabenzotriazol (14 mg, 0.1 mmol), N,Ndiisopropylethylamine (260 μl, 1.5 mmol), 3-amino-2,6- dimethoxypyridine monohydrochloride (190 mg, lmmol) , molecular aieves (3A) and the reaction mixture was stirred 24h at RT. After filtration, methylisocyanate resin (1 g, 1 mmol) was added to the filtrate and the mixture was stirred for another 24H at RT. The mixture was filtered, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography eluting with a gradient of cyclohexane containing from 0 to 10% ethyl acetate to afford 60 mg of the title product. Yield: 26% X H-NMR (400MHz, DMSO) δ PP™: 1.15-1.35 (m, 5H) , 1.50-1.60 (m, IH) , 1.70-1.80 (m, 4H) , 2.55-2.65 (m, IH) , 3.50 (s, 3H) , 3.85 (s, 3H) , 3.90 (a, 3H) , 6.35 (d, IH) , 7.70-7.80 (m, 3H) , 8.00 (d, 2H) , 9.65 (s, IH) . MS (m/z) / M+l= 454 HPLC (uv purity, λ= 214 nm) : 99.9% Example 137.7: Rl= cyclohexyl, R2= methyl, R3= 4-N- isopropyl-benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N-isopropyl-benzamide To a solution of LiOH monohydrate (794 mg, 19 mmol) in 18 ml of water , a solution of 137 (5.7g, 17.2 mmol) in THF/MeOH (50/50) (100 ml) was added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water and a solution of HCl (0.1N, 361 ml) was added. The resulting mixture was stirred for 3H30. After distillation of water, the crude product was dried over P 2 0 5 in vacuo. To a suspension of 200 mg (0.5 mmol) of this crude material in CH 2 C1 2 /DMF (50/50) (6 ml) were added cyclocarbodiimide-N-methyl resin (1.03 g, 1.5 mmol), 1-hydroxy-7-azabenzotriazol (15 mg, 0. lmmol), N,Ndiisopropylethylamine (175 μl, 1 mmol) , isopropylamine (85 μl, 1 mmol) , molecular sieves (3A) and the reaction mixture was stirred 24H at RT. After filtration, Methylisocyanate resin (1 g, 1 mmol) was added to the filtrate and the mixture was stirred for another 24H at RT. The mixture was filtered, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography eluting with a gradient of cyclohexane containing from 0 to 20% ethyl acetate to afford 40 mg of the title product. Yield: 22% X H-NMR (400MHz, DMSO) δ PP™: 1.15-1.40 (m, 11H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.70 (m, IH) , 3.55 (s, 3H) , 4.05-4.15 (m, IH) , 7.70 (d, 2H) ,. 7.90 (d, 2H) , 8.30 (d, IH) . MS (m/z) / M+l= 359 HPLC (uv purity, λ= 214 nm) : 99.9% Example 137.8: Rl= cyclohexyl, R2= methyl, R3= 4-N-ethyl- benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N-ethyl-benzamide To a solution of 2M ethylamine (1.8 ml, 3.6 mmol) in dichloroethane (5 ml) under nitrogen at 0°C, was added 2M trimethylaluminium (1.8 ml, 3.6 mmol) and the mixture "was atirred at RT for 15min. Then, a solution of compound 137 (180 mg, 0.54 mmol) in dichloroethane (5 ml) was added and the reaction mixture was allowed to stir for 48 h at RT. A solution of 2M ethylamine (0.8 ml, 1.6 mmol) and of 2M trimethylaluminium (0.8 ml, 1.6 mmol) were added to allow reaction to completion and the mixture was stirred at RT for another 24H. The mixture was diluted with 50 ml of dichloromethane and 30 ml of water, stirred for 2H, and filtered through Celite. The filtrate was waahed with water, brine and the organic layer was dried over MgS0 , filtered, and concentrated under reduced pressure. The residue was subjected to flaah chromatography eluting with a gradient of cyclohexane containing from 0 to 20% ethyl acetate to afford 60 mg of the title product. Yield: 32% X H-NMR (400MHz, DMSO) δ ppm: 1-20 (t, 3H) , 1.20-1.50 (m, 5H) , 1.60-1.70 (m, IH) , 1.80-1.95 (m, 4H) , 2.70-2.80 (m, IH) , 3.35-3.45 (m, 2H) , 3.65 (a, 3H) , 7.90 (d, 2H) , 8.05 (d, 2H) , 8.65 (m, IH) . MS (m/z) / M+l= 344.7 HPLC (uv purity, λ= 214 nm) : 99.9% Example 137.8-1: Rl= cyclohexyl, R2= methyl, R3= 4- (1-ethyl- lH-tetrazol-5-yl) -phenyl Cyclohexyl- {5- [4- (l-ethyl-lH-tetrazol-5-yl) -phenyl] -3- methyl-3H- [1,3,4] thiadiazol-2-ylidene}-amine To a aolution of 137.8 (0.29 mmol, 100 mg). in acetonitrile (3 ml) at 0°C under a nitrogen atmosphere, sodium azide (0.44mmol, 28mg) and trifluoromethanesulfonic anhydre (0.44 mmol, 73 μl) were added. Then, the mixture was stirred overnight at room temperature and a satured solution of NaHC0 3 to pH=7 was added. The aqueous layer was extracted with dichloromethane and the organic layer was washed with water, brine, dried over magnesium sulfate, *" filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with a gradient of dicloromethane/methanol, then by HPLC ' (Gia- HYPERSYL column) , eluting with water containing from 5 to 95% acetonitrile in 20 min to afford the title product. Yield: 9% X H-NMR (400MHz, DMSO) δ PPm: 1.20-1.40 (m, 5H) , 1.47 (t, 3H) , 1.55-1.65 (m, IH) , 1.70-1.82 (m, 4H) , 2.50-2.55 (m, IH) , 3.55 (S, 3H) , 4.52 (q, 2H) , 7.85-7.90 (m, 4H) . MS (m/z) / M+l= 370 HPLC k (uv purity, λ = 214 nm) = 96.8% Example 137.9: Rl= cyclohexyl, R2= methyl, R3= 4-N- (2- dimethylamino-ethyl) -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N- (2-dimethylamino-ethyl) -benzamide To a solution of N,N-dimethylethylenediamine (335 μl, 3 mmol) in dichloroethane (5 ml) under nitrogen atmosphere at 0°C, was added 2M trimethylaluminium (1.5 ml, 3 mmol), and the mixture was stirred at RT for 1H30. Then, a solution of compound 137 (180 mg, 0.54 mmol) in dichloroethane (5 ml) was added and the reaction mixture was allowed to stir for 24 h at RT and 24h at 45°C The mixture was diluted with 10ml of dichloromethane and 20ml of water, stirred for 1H30, and filtered through Celite. The filtrate was washed with water, brine and the organic layer was dried over MgS0 4 , filtered, and concentrated under reduced pressure. The residue was subjected to silica gel chromatography eluting with a gradient of dichloromethane containing 0 to 5% methanol to afford 140 mg of the title product. Yield: 60% X H-NMR (400MHz, DMSO) δ PP™: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.25 (s, 6H) , 2.60-2.70 (m, IH) , 3.55 (s, 3H) , 7.75 (d, 2H) , 7.90 (d, 2H) , 8.50 (m, IH) MS (m/z) / M+l= 388 HPLC (uv purity, λ = 214 nm) : 99.4% Example 137.10: Rl= cyclohexyl, R2= methyl, R3= 4-N-pyridin- 4-ylmethyl-benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazόl- 2-yl) -N-pyridin-4-ylmethyl-benzamide To a solution of LiOH monohydrate (794 mg, 19 mmol) in 18 ml of water , a solution of compound 137 (5.7 g, 17.2 mmol) in THF/MeOH (50/50) (100 ml) was added. The mixture was stirred at RT for 24H and then concentrated under reduced pressure. The residue was dissolved in water and a solution of HCl (0.1N, 361 ml) was added. The resulting mixture was stirred for 3H30. After distillation of water, the crude product was dried over P 2 0 5 in vacuo. To a suspension of 200 mg (0.5 mmol) of the crude material in CH 2 C1 2 /DMF (50/50) (6 ml) were added cyclocarbodiimide-N-methyl resin (1.03 g, 1.5 mmol) , 0- (7-azabenzotriazol-l-yl) -N,N,N' ,N' -tetramethyl- uronium hexafluorophosphate (38 mg, 0. lmmol), N,Ndiisopropylethylamine (175 μl, 1 mmol) , 4-picolylamine (105 μl, 1 mmol) , molecular sieves (3A) and the reaction mixture was stirred 3 days at RT. This mixture was filtered, and in the organic layer was added methylisocyanate resin (1 g, 1 mmol) and stirred 3 days at RT. After filtration, the filtrate was concentrated under reduced pressure. The solid waa poured into water and the mixture was stirred for 1 h, before extraction with dichloromethane. The organic layer was dried over MgS0 4 , filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 5% methanol to afford 30 mg of the title product. Yield: 15% X H-NMR (400MHz , DMSO) δ PPm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.75 (m, IH) , 3.55 (s, 3H) , 4.50 (d, 2H) , 7.35 (d, 2H) , 7.75 (d, 2H) , 8.00 (d, 2H) , 8.50 (d, 2H) , 9.25 (m, IH) . MS (m/z) / M+l= 408 HPLC (uv purity, χ = 214 nm) : 99.7% Example 137.11: Rl= cyclohexyl, R2= methyl, R3= 4-N-methyl- N- (l-methyl-piperidin-4-yl) -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N-methyl-N- (1-methyl-piperidin-4-yl) -benzamide To a solution of 137.1 (0.5 mmol, 200 mg) in DMF (2.5 ml), ethyl-diisopropyl-amine (1.6 mmol, 190 μl) , benzotriazol-1- yloxytris (dimethylamino)phosphonium hexafluorophosphate (0.6 mmol, 265 mg) , l-hydroxy-7-azabenzotriazole (0.25 mmol-, 34 mg) and 1-methyl-4- (methylamino)piperidine (0.6 mmol, 87 μl) were added and the reaction mixture was stirred at room temperature overnight. The solvent was distilled under reduced pressure and the residue was poured into water before extraction with dichloromethane. The organic layer was washed with brine and then with a saturated solution of NaHC0 3 , dried over magnesium sulfate, filtered and concentrated under vaccum. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 15% methanol, to give the desired product . Yield: 93.5% X H-NMR (400MHz, DMSO) , Ppm: 1.23-1.45 (m, 5H) , 1.55-1.65 (m, IH) , 1.68-1.85 (m, 6H) , 1.85-2.00 (m, 2H) , 2.23-2.44 (m, 5H) , 2.55-2.65 (m, IH) , 2.83 (a, 3H) , 3.00-3.10 (m, 2H) , 3.55 (a, 3H) , 3.85-4.03 (m, IH) , 7.48 (dd, 2H) , 7.70 (dd, 2H) . MS (m/z) / M+l= 428 HPLC (uv purity, X = 214 nm) = 99.4% Example 137.12: Rl= cyclohexyl, R2= methyl, R3= 4-N- isobutyl-benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N-isobutyl-benzamide To a solution of 137.1 (0.5 mmol, 200 mg) in DMF (2.5 ml), ethyl-diisopropyl-amine (1.6 mmol, 190 μl) , benzotriazol-1- yloxytris (dimethylamino)phosphonium hexafluorophosphate (0.6 mmol, 265 mg) , l-hydroxy-7-azabenzotriazole (0.25 mmol, 34 mg) and isobutylamine (2.3 mmol, 80 μl) were added and the reaction mixture was stirred at room temperature overnight. The solvent was distilled and the residue was poured into water before extraction with dichloromethane. The organic layer was washed with brine, a saturated solution of NaHC03, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give the desired product . Yield: 86% X H-NMR (400MHz , DMSO) δ ppm: 0.90 (d, 6H) , 1.20-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.72-1.90 (m, 5H) , 2.60-2.70 (m, IH) , 3.10 (t, 2H) , 3.55 (a, 3H) , 7.72 (dd, 2H) , 7.92 (dd, 2H) , 8.55 (t, IH) . MS (m/z) / M+l= 373 HPLC (uv purity, χ = 214 nm) = 98.4% Example 137.13: Rl= cyclohexyl, R2= methyl, R3 : 4-N-methyl- benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N-methyl-benzamide To a solution of 137.1 (4.25 mmol, 1,7 g) in DMF (20,5 ml) was added N-ethyldiisopropylamine-N,N-diisopropylethylamine (13.6 mmol, 1.615 ml), benzotriazol-1-yloxytris (dimethylamino) phosphonium hexafluorophosphate (5.1 mmol, 2.265 g) , 1-hydroxy-7-azabenzotriazole (2.125 mmol, 290 mg) and a solution of methylamine at [2N] in methanol (5.1 mmol, 3.55 ml) . The mixture was stirred at room temperature overnight . The mixture was reduced under presaure vacuum, extracted with dichloromethane in water. The organic layer waa washed with brine, dried over magnesium sulfate and reduced under pressure vacuum. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0, to 4% methanol, to give a residue which was stirred in diethylether during one hour. The precipitate was filtred and dried under vacuum over P 2 0 5 to give 550 mg of the desired product. Yield: 44% X H-NMR (400MHz, DMSO) PP™: 1.18-1.45 (m, 5H) , 1.55-1.68 (m, IH) ,.1.68-1.83 (m, 4H) , 2.60-2.70 (m, 1H), ,2.80 (d, 3H) , 3.55 (s, 3H) , 7.82 (dd, 2H) , 7.92 (dd, 2H) , 8.55 (q, IH) . MS (m/z) / M+l= 331 HPLC (uv purity, λ= 214 nm) = 99.9% t ~ Example 137.13-1: Rl= cyclohexyl, R2= methyl, R3= 4-N-(2- dimethyl mino-ethyl) -N-methyl-benzamide 4- (Cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2- yl) -N- (2 -dimethylamino-ethyl) -N-methyl-benzamide To a suspension of 137.13 (0.3 mmol, 100 mg) in dimethylformamide (1 ml) , sodium hydride at 60% dispersion in mineral oil (0.6 mmol, 24 mg) , 2- dimethylaminoethylchloride hydrochloride (0.36 mmol, 52 mg) and K 2 C0 3 (0.36 mmol, 50 mg) were added. The mixture was stirred overnight at 40 °C Then, potassium ter-butoxyde (0.18 mmol, 20 mg) was added and the mixture was atirred during 24H. 2-dimethylaminoethylchloride hydrochloride (0.18 mmol, 26 mg) , and K 2 CO 3 (0.18 mmol, 25 mg) were added and Ml warmed at 40°C overnight. The mixture was reduce under pressure vacuum to give a residue which was purified by silica gel chromatography, eluting with a gradient of dicloromethane containing from 0 to 6% methanol to afford the title product. Yield: 16% X H-NMR (400MHz , DMSO) δ PPm: 1.20-1.42 (m, 5H) , 1.55-1.65 ( , IH) , 1.70-1.85 (m, 4H) , 2.00 (s, 3H) , 2.25 (a, 3H) , 2.30-2.40 (m, IH) , 2.60-2.70 (m, IH) , 2.88-3.02 (m, 3H) , 3.55 (s, 3H) , 7.45 (dd, 2H) , 7.70 (dd, 2H) . MS (m/z) / M+l= 402 HPLC (uv purity, X = 214 nm) = 98.8% Example 137.14: Rl= cyclohexyl, R2= methyl, R3= 4- (3- hydroxy-methyl-piperidin-1-carbonyl) -phenyl [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2 -yl) -phenyl] -1- (3-hydroxymethyl- piperidin-1-yl) -methanone Compound 137.14 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 5% methanol, to give the desired product. Yield: 34% X H-NMR (350K, 400MHz, DMSO) δ PPm: 1.20-1.50 (m, 7H) , 1.50- 1.70 (m, 3H) , 1.70-1.85 ( , 5H) , 2.63-2.78 (m, 2H) , 2.88- 2.98 (m, IH) , 3.18-3.28 (m, IH) , 3.28-3.38 (m, IH) , 3.50 (s, 3H) , 3.75-4.10 (m, 2H) , 4.18-4.28 (m, IH) , 7.45 (dd, 2H) , 7.68 (dd, 2H) . MS (m/z) / M+l= 415 HPLC (uv purity, χ= 214 nm) = 95.4% Example 137.15: Rl= cyclohexyl, R2= methyl, R3= 4-{N-[(S)-l- tert-butoxycarbonyl-2- (4-hydrox -phenyl) -ethyl] }benzamide 2- [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoylamino] -3- (4-hydroxy-phenyl) - propionic acid tert-butyl ester Compound 137.15 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 2% methanol and then the product was washed with water, extracted with ethylacetate and the organic layer was washed with brine, dried over magnesium sulfate and reduced under pressure vacuum to give the title product. Yield: 70% X H-NMR (400MHz, DMSO) δ PPm: 1.20-1.40 (m, 14H) , 1.55-1.65 (m, IH) , 1.70-1.80 (m, 4H) , 2.58-2.68 (m, IH) , 2.91-3.01 (m, 2H) , 3.52 (s, 3H) , 4.45-4.51 (m, IH) , 6.65 (dd, 2H) , 7.08 (dd, 2H) , 7.71 (dd, 2H) , 7.90 (dd, 2H) , 8.75 (d, IH) , 9.15 (s, IH) . MS (m/z) / M+l= 537 HPLC (uv purity, λ= 214 nm) = 96.3% Example I37.15-a: Rl= cyclohexyl, R2= methyl, R3= 4- [N- ( (S) - l-carboxy-2- (4-hydroxy-phenyl) -ethyl) ] benzamide (S) -2- [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2 -yl) -benzoylamino] -3- (4-hydr xy-phenyl) - propionic acid; compound with 2,2,2-trifluoro-acetic acid To a solution of 137.15 (0.186 mmol, 100 mg) in dichloromethane (1.5 ml), trifluoroacetic acid (4.4 mmol, 378 μl) was added and the mixture was stirred at reflux during 2 hours. The mixture was purified by silica gel chromatography, eluting with a gradient of dicloromethane containing from 0 to 10% methanol to afford 60 mg of the title product. Yield: 54% X H-NMR (400MHz, DMSO) δ PPm: 1.12-1.52 (m, 5H) , 1.58-1.68 (m, IH) , 1.73-1.85 (m, 2H) , 1.85-2.05 (m, 2H) , 2.88-3.11 (m, 3H) , 3.75 (s, 3H) , 4.48-4.60 (m, IH) , 6.62 (dd, 2H) , 7.08 (dd, 2H) , 7.85 (dd, 2H) , 7.95 (dd, 2H) , 9.15 (s, IH) , 12.75 (s, IH) . MS (m/z) / M+l= 481 HPLC (uv purity, λ= 214 nm) = 98% Wb Example 137.16: Rl= cyclohexyl, R2= methyl, R3= 4- (N- ( (S) -1- tert-butoxycarbonyl) -ethyl) benzamide (S) -2- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoylamino] -propionic acid tert- butyl ester Compound 137.16 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 2% methanol, and the product was washed with water, filtrered and dried under pressure vacuum with P2O5 to give the title compound. Yield: 65% X H-NMR ( 400MHz , DMSO) δ PPm: 1.20-1.40 (m, 17H) , 1.55-1.65 (m, IH) , 1.70-1.82 (m, 4H) , 2.58-2.68 (m, IH) , 3.52 (s, 3H) , 4.35 (q, IH) , 7.73 (dd, 2H) , 7.95 (dd, 2H) , 8.75 (d, IH) . MS (m/z) / M+l= 445 HPLC (uv purity, λ= 214 nm) = 99.3% Example I37.16-a: Rl= cyclohexyl, R2= methyl, R3= 4- (N- ( (S) - 1-carboxy) -ethyl) benzamide (S) -2- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -benzoylamino] -propionic acid; compound with 2,2,2-trifluoro-acetic acid To a solution of 137.16 (0.225 mmol, 100 mg) in dichloromethane (1 ml) at 0°C, trifluoroacetic acid (5.85 mmol, 457 μl) was added and the mixture was stirred at room temperature overnight. The mixture was purified by silica gel chromatography, eluting with a gradient of dicloromethane containing from 0 to 5% methanol to afford 40 mg of the title product. Yield: 35% X H-NMR (400MHz, DMSO) δ P™: 1.10-1.48 (m, 8H) , 1.55-1.65 (m, IH) , 1.70-1.81 (m, 2H) , 1.81-2.00 (m, 2H) , 2.89-3.05 (m, IH) , 3.71 (s,3H), 4.44 (q, IH) , 7.87 (dd, 2H) , 8.03 (dd, 2H) , 8.82 (d, IH) , 12.57 (s, IH) . MS (m/z) / M+l= 388/389 "<+ HPLC (uv purity, λ= 214 nm) = 97.9% Example 137.17: Rl= cyclohexyl, R2= methyl, R3= 4- (4- pyridin-2-yl-piperazine-l-carbonyl) -phenyl [4- (5-Cyclohexylimino-4-meth 1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - (4-pyridin-2-yl-piperazin-l- yl) -methanone Compound 137.17 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 5% methanol, and then the product was washed with water, filtered and dried under reduced pressure over P2O5 to give the desired product . Yield: 82% X H-NMR ( 400MHz, DMSO) δ PPm: 1.15-1.48 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-2.00 (m, 4H) , 2.62-2.92 (m, IH) , 3.35-3.87 (m, 11H) , 6.67 (dd, IH) , 6.88 (d, IH) , 7.45-7.63 (m, 3H) , 7.78 (dd, 2H) , 8.12 (d, IH) . MS (m/z) / M+l= 463 HPLC (uv purity, = 214 nm) = 99.9% Example 137.18: Rl= cyclohexyl, R2= methyl, R3= 4- [4- (4- fluoro-phenyl) -piperazine-1-carbonyl] -phenyl [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - [4- (4-fluoro-phenyl) - piperazin-1-yl] -methanone Compound 137.18 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 5% methanol, and then the product was washed with water, filtred and dried under reduced pressure over P2O5 to give the desired product . Yield: 31% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.65-1.86 (m, 4H) , 2.56-2.70 (m, IH) , 2.96-3.10 (m, M S " 4H) , 3 . 37 -3 . 85 (m, 7H) , 6 . 67 (dd, IH) , 6 . 92 - 7 . 12 (m, 4H) , 7 . 51 (dd, 2H) , 7 . 71 (dd, 2H) . MS (m/ z ) / M+l= 480 HPLC (uv purity, λ= 214 nm) = 98.6% Example 137.19: Rl= cyclohexyl, R2= methyl, R3= 4- [N- (3,4,5- trimethoxy-benzyl) ] -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N- (3,4,5-trimethoxy-benzyl) -benzamide Compound 137.19 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of cyclohexane containing 0 to 30% ethylacetate, to give a product which was washed with water, filtred and dried under reduced pressure over P 2 0 5 to give the desired product . Yield: 52% X H-NMR (400MHz, DMSO) δ PP™= 1.19-1.42 (m, 5H) , 1.55-1.65 (m, IH) , 1.71-1.88 (m, 4H) , 2.60-2.70 (m, IH) , 3.50-3.55 (m, 3H) , 3.55 (s, 3H) , 3.75 (a, 6H) , 4.42 (d, 2H) , 6.65 (a, 4H) , 7.70-7.80 (m, IH) , 8.00 (d, IH) , 9.10 (t, IH) . l MS (m/z) / M+l= 497 HPLC (uv purity, λ= 214 nm) = 99.5% Example 137.20: Rl= cyclohexyl, R2= methyl, R3= 4- (4- pyrimidin-2-yl-piperazin-l-carbonyl) -phenyl [4 - (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - (4-pyrimidin-2-yl-piperazin- 1-yl) -methanone Compound 137.20 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 1% methanol, to give a product which was washed with water, filtred and dried under reduced pressure over P 2 0 5 to give the desired product . Yield: 4% l i b X H-NMR (400MHz, DMSO) δ Ppm: 1.15-1.41 (m, 5H) , 1.55-1.65 (m, IH) , 1.68-1.75 (m, 4H) , 2.55-2.70 (m, IH) , 3.00-3.90 (m, 11H) , 6.65 (t, IH) , 6.88 (d, IH) , 7.50 (dd, 2H) , 7.70 (dd, 2H) , 8.38 (d, 2H) . MS (m/z) / M+l= 464 HPLC (uv purity, λ= 214 nm) = 97% Example 137.21: Rl= cyclohexyl, R2= methyl, R3= 4- (4-methyl- piperazine-1-carbonyl) -phenyl [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - (4-methyl-piperazin-l-yl) - methanone Compound 137.21 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of of dichloromethane containing 0 to 10% methanol, to give a product which was washed with water, filtred and dried under reduced pressure over P 2 0s to give the desired product. Yield: 55% X H-NMR (400MHz, DMSO) δ PPm: 1.18-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.69-1.81 (m, 4H) , 2.25 (s, 3H) , 2.33-2.52 (m, 4H) , 2.59-2.69 (m, IH) , 3.25-3.45 (m, 2H) , 3.52 (s, 3H) , 3.55- 3.70 (m, 2H) , 7.78 (dd, 2H) , 7.71 (dd, 2H) . MS (m/z) / M+l= 400 HPLC (uv purity, λ= 214 nm) = 99.6% Example 137.22: Rl= cyclohexyl, R2= methyl, R3= 4-[N-(3-(4- methyl-piperazin-1-yl) -propyl) ] benzamide 4- (5-Cyσlohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N- [3- (4-methyl-piperazin-l-yl) -propyl] -benzamide Compound 137.22 was prepared by the procedure described in exemple 137.11 using 137.1 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 10% methanol, to give a product which was stirred in diethylether, filtred and dried under reduced pressure over P2O5 to give the desired product . Yield: 3.5% X H-NMR (400MHz, CDC1 3 ) : δ PPm: 1.20-1.50 (m, 5H) , 1.60-2.05 (m, 7H) , 2.35 (s, 3H) , 2.48-2.85 (m, 11H) , 3.52-3.64 (m, 2H) , 3.50 (s, 3H) , 7.68 (dd, 2H) , 7.87 (dd, 2H) , 8.00-8.08 (m, IH) . MS (m/z) / M+l= 457 HPLC (uv purity, λ= 214 nm) = 97.2% Example 137.23: Rl= cyclohexyl, R2= methyl, R3= 4-N- Ed- ethyl-pyrrolidin-2 -ylmethyl) -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N- (1-ethyl-pyrrolidin-2-ylmethyl) -benzamide To a solution of 2- (aminomethyl) -1-ethylpyrrolidine (7.5 mmol, 967 mg) in dichloroethane (10 ml) under nitrogen atmosphere, was added dropwise trimethylaluminium [2N] in toluene (7.5 mmol, 3.8 ml) and the mixture was stirred at room temperature during 2 hours . A solution of compound 137 (1.5 mmol, -500 mg) in dichloroethane (10 ml) was then added and the stirring was pursued at 65°C overnight. At room temperature, dichloromethane (30 ml) and waters (50 ml) were added and the mixture was stirred several hours. The mixture was filtered through celite, extracted with dichloromethane, washed with water and brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 10% methanol to afford the desired product . Yield: 79% X H-NMR (400MHz, DMSO) δ PPm: 1.05 (t, 3H) , 1 . 20 - 1 . 42 (m, 5H) , 1.55-1.70 (m, 4H) , 1.70-1.85 (m, 5H) , 2 . 10 -2 . 18 (m, IH) , 2.25-2.35 (m, IH) , 2.55-2.70 (m, 2H) , 2 . 80 -2 . 90 (m, IH) , 3.00-3.12 (m, 2H) , 3.39-3.49 (m, IH) , 3.55 (s, 3H), ~ 7.'71 (dd, 2H) , 7.92 (dd, 2H) , 8.49 (t, IH) . MS (m/z) / M+l= 428 HPLC (uv purity, λ= 214 nm) = 99.2% I| 8 Example 137.24: Rl= cyclohexyl, R2= methyl, R3= 4-N- [ (pyridin-3-ylmethyl) -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N-pyridin-3-ylmethyl-benzamide Compound 137.24 was prepared by the procedure described in example 137.23 using appropriate intermediates and reagents (137 and 2- (aminoethyl) pyridine) . The residue was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 8% methanol to afford the desired product. Yield: 34% X H-NMR (400MHz, DMSO) δ P m: 1.20-1.42 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.70 (m, IH) , 3.55 (s, 3H) , 4.50 (d, 2H) , 7.35-7.40 (m, IH) , 7.70-7.80 (m, 3H) , 8.00 (dd, 2H) , 8.45-8.50 (m, IH) , 8.57 (s, IH) , 9.30 (t, IH) . MS (m/z) / M+l= 408 HPLC (uv purity, λ= 214 nm) = 98.6% Example 137.25: Rl= cyclohexyl, R2= methyl, R3= 4- (N- benzyl) -benzamide N-Benzyl-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide Compound 137.25 was prepared by the procedure described in example 137.23 using appropriate intermediates and reagenta (137 and benzylamine) . The reaidue was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 2% methanol to afford the desired product. Yield: 34% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.65-1.85 (m, 4H) , 2.55-2.70 (m, IH) , 3.52 (s, 3H) , 4.48 (d, 2H) , 7.19-7.39 ( , 5H) , 7.72 (dd, 2H) , 7.98 (dd, 2H) , 9.13 (t, IH) MS (m/z) / M+l= 407 HPLC (uv purity, χ= 214 nm) = 99.2% Example 137.26: Rl= cyclohexyl, R2= methyl, R3= 4- [N- (1- U°| benzyl-piperidin-4-yl) ] -benzamide N- (1-Benzyl-piperidin-4-yl) -4- (5-cyclohexylimino-4-methyl- 4, 5-dihydro- [1,3,4] hiadiazol-2 -yl) -benzamide Compound 137.26 was prepared by the procedure described in example 137.23 using appropriate intermediates and reagents (137 and 4-amino-l-benzylpiperidine) . The residue was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 8% methanol to afford the desired product. Yield: 50% X H-NMR (400MHz, DMSO) δ PP™: 1.15-1.40 (m, 5H) , 1.53-1.65 (m, 3H) , 1.70-1.83 (m, 6H) , 1.97-2.07 (m, 2H) , 2.70-2.80 (m, IH) , 2.77-2.87 (m, 2H) , 3.47 (s, 2H) , 3.55 (a, 3H) , 3.70- 3.85 (m, IH) , 7.22-7.35 (m, 5H) , 7.70 (dd, 2H) , 7.93 (dd, 2H) , 8.35 (d, IH) . MS (m/z) / M+l= 490 HPLC (uv purity, λ= 214 nm) = 96.4% Example 37.27: Rl= cyclohexyl, R2= methyl, R3= 4-[N-(2- ethyl-2H-pyrazol-3-yl) ] -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,.4] hiadiazol- 2-yl) -N- (2-ethyl-2H-pyrazol-3-yl) -benzamide Compound 137.27 was prepared by the procedure described in example 137.23 using appropriate-"intermediates and reagents (137 and 5-amino-l-ethylpyrazole) . The residue was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 6% methanol and then the solid was stirred in diethylether during 15 min, filtered and dried under reduced pressure to give the title product. Yield: 26% X H-NMR (400MHz, DMSO) δ PPm: 1.20-1.-45 (m, 8H) , 1.60-1.70 (m, IH) , 1.75-1.87 (m, 4H) , 2.63-2.73 (m, ΪH)\ 3.55 (s, 3H) , 4.05 (q, 2H) , 6.25 (d, IH) , 7.45 (d, IH) , 7.83 (dd, 2H) , 8.10 (dd, 2H) , 10.40 (s, IH) . MS (m/z) / M+l= 411 HPLC (uv purity, λ= 214 nm) = 99.7% \1 Example 137.28: Rl= cyclohexyl, R2= methyl, R3= 4- (2- morpholin-4-yl-ethyl) -benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N- (2-morpholin-4-yl-ethyl) -benzamide Compound 137.28 was prepared by the procedure described in example 137.23 using appropriate intermediates and reagents (137 and N- (2-aminoethyl) morpholine) . The residue was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 6% methanol and then the solid was stirred in diethylether during 15 min, filtered and dried under reduced pressure to give the title product. Yield: 21% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.40 (m, 5H) , 1.55-1.63 (m, IH) , 1.70-1.83 (m, 5H) , 2.35-2.50 (m, 6H) , 2.57-2.67 (m, IH) , 3.38 (q, 2H) , 3.50 (s, 3H) , 3.52-3.57 (m, 4H) , 7.80 (dd, 2H) , 7.90 (dd, 2H) , 8.50 (t, IH) MS (m/z) / M+l= 430 HPLC (uv purity, λ= 214 nm) = 99.9% Example 137.28-1: Rl= cyclohexyl, R2= methyl, R3= 4-[(N- cyano-N'-ethylmorpholine) -carboxyxmidamxne] -phenyl [5- (4- ( (N-cyano-N" -ethylmorpholine) -carboximidamide) - phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl- amine To a solution of 137.28 (2.33 mmol, 1 g) in toluene (15 ml), Lawesson's reagent (4.65 mmol, 1.88 g) was added and the mixture was stirred overnight at reflux. After cooling at room temperature, the mixture was acidified with a solution of HCl at 5% (3.5 ml) then basified with a solution of NaHC0 3 . The aqueous layer was extracted with ethylacetate and the combined organic layers were 'washed with water, brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 4- (5- cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2- yl) -N(2-morpholin-4-yl-ethyl) thiobenzamide . Yield: 56% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.83 (m, 4H) , 2.60-2.75 (m, 3H) , 3.52 (s, 3H) , 3.55-3.63 (m, 4H) , 3.78 (t, 2H) , 3.80-3.90 (m, 2H) , 7.70 (dd, 2H) , 7.82 (dd, 2H) , 10.28 (t, IH) . To a solution of 4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N(2-morpholin-4-yl- . ethyl) thiobenzamide (1.12 mmol, 500 mg) in THF (20 ml), sodium hydride (60% dispersion in mineral oil, 1.12 mmol, 44 mg) was added and the mixture was warmed at reflux during one hour. After cooling at room temperature, methyl iodide (1.35 mmol, 84 μl) was added and the mixture was warmed 4 hours at reflux and then overnight at room temperature . The mixture was concentrated under reduced pressure to give a crude material which was solubilized in ethanol (50 ml) . To this solution, cyanamide (1.8 mmol, 75 mg) and triethylamine (0.9 mmol, 125μl) were added and the mixture was stirred 2 days at reflux. Mercury (II) chloride (1.68 mmol, 457 mg) and cyanamide (2.35 mmol, 100 mg) were added and the reaction was allowed to stir 3 days at room temperature. The mixture was concentrated under reduced pressure and the residue was diluted in ethyl acetate and filtered through celite. The filtrate was concentrated under vacuum. The residue was chromatographed on silica gel using a gradient ' - • of dichloromethane containing from 0 to 5% methanol to afford the title compound. Yield: 17% X H-NMR (400MHz, DMSO) δ PP™: 1.18-1.42 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.40-2.50(m, 4H) , 2.50-2.60(m, 2H) , 2.60-2.70 (m, IH) , 3.45-3.55(m, 2H) , 3.55 (s, 3H) , 3.55-3.65(m, 4H) , 7.68 (dd, 2H) , 7.52 (dd, 2H) , 9.15 (t, IH) . . MS (m/z) / M+l= 454 HPLC (uv purity, λ= 214 nm) = 95% Example 137.29: Rl= cyclohexyl, R2= methyl, R3= 4-N-(2- pyrrolidin-1-yl-ethyl) -benzamide 4- (5-Cyclohexylimino-4-methy1-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -N- (2-pyrrolidin-l-yl-ethyl) -benzamide Compound 137.29 was prepared by the procedure described in example 137.23 using appropriate intermediates and reagents (137 and 1- (2-aminoethyl) pyrolidine) . The residue was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 14% methanol to afford the desired product. Yield: 26% X H-NMR (400MHz, DMSO) δ PP™: 1.20-1.45 (m, 5H) , 1.60-1.87 (m, 9H) , 2.45-2.70 (m, 7H) , 3.35-3.45 (m, 2H) , 3.60 (s, 3H) , 7.73 (dd, 2H) , 7.95 (dd, 2H) , 8.55 (t, IH) . MS (m/z) / M+l= 414 HPLC (uv purity, λ= 214 nm) = 99.9% Protocol D EXAMPLE I: PROTOCOL D Example 115: Rl= cyclohexyl, R2= methyl, R3= 4- methy1sulfonyl-phenyl Cyclohexyl- [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine To a mixture of 4-methylsulfonyl-benzoic acid (2.5 mmol, 500 mg) , 2 -methylthiosemicarbazide 5a (2.5 mmol, 468 mg) in anhydrous dioxane (5 mL) at 65°C, POCl 3 (3 mmol, 280 μl) was added and the mixture was warmed at 95°C for 5 hours. The solvent was removed by distillation under reduced pressure to give a crude material which was basified at pH 8-7 with a saturated solution of NaHC0 3 . The aqueous phase was extracted with dichoromethane. The organic layer was washed with saturated solution of NaCl, dried over magnesium sulfate, filtered and distilled to give a residue which was purified by silica gel chromatography (eluted with a gradient of cyclohexane/ethyl acetate finishing with the ratio 80/20) to afford 230 mg of the title compound. Yield: 26% X H-NMR (400MHz, DMSO) δ PPm: 1.25-1.45 (m, 5H) , 1.65-1.75 (m, IH) , 1.75-1.95 (m, 4H) , 1.70-1.80 (m, IH) , 3.35 (s, 3H) , 3.65 (a, 3H) , 8.05 (dd, 4H) . MS (m/z) / M+l= 352.5 HPLC (uv purity, χ= 214 nm) : 95.3% The compounds of the following examples were prepared by the procedure described in example 115 using appropriate intermediates and reagents : 115.1 [3- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -dimethyl-amine 115.2 Cyclohexyl- [5- (3-methoxy-4-nitro-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -amine Example 138: Rl= cyclohexyl, R2= Me, R3= 3-pyridyl Cyclohexyl- (3-methyl-5-pyridin-3-yl-3H- [1,3,4] thiadiazol ώ 2- ylidene) -amine Compound 138 was prepared by the procedure described in example 115 (protocol D) using appropriate intermediates and reagents. The title product was isolated by chromatography on silica gel eluting with cyclohexane containing from 0 to 10% ethylacetate. Yield= 0.06 g, 13.5% X H-NMR (400MHz, DMSO) ' δ PP : 1.20-1.44 (m, 5H) , 1.59-1.64 (b, IH) , 1.73-1.83 (b, 4H) , 2.61-2.70 (b, IH) , 3.54 (a, 3H) , 7.50-7.53 (m, IH) , ' 8.0 . (d, IH) , 8.63-8.67 (m, IH) , 8.85 (s, IH) . MS (m/z) / M+l= 275/276 HPLC (uv purity, „λ= 214 nm) = 95.87% Example 139: Rl= cyclohexyl, R2= methyl, R3= 3-sulfamoyl- phenyl 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -benzenesulfonamide Compound 139 was prepared by the procedure described in example 115 (protocol D) using appropriate intermediates and reagents . The title product was isolated by chromatography on silica gel eluting with dichloromethane containing from 0 to 5% methanol . Yield= 8.0 % X H-NMR (400MHz, DMSO) δPPm: 1.18-1.41 ( , 5H) , 1.58-1.63 (m, IH) , 1.73-1.84 (m, 4H) , 2.60-2.67 (m, IH) , 3.56 (s, 3H) , 7.48 (s, 2H) , 7.67 (t, IH) , 7.82-7.90 (m, 2H) , 8.12 (s, IH) . MS (m/z) / M+l= 353/354 HPLC (uv purity, χ= 214 nm) = 97.55% Example 140: Rl= cyclohexyl, R2= methyl, R3= benzo [1,3] dioxol-5-yl (5-Benzo[l,3]dioxol-5-yl-3-methyl-3H- [1, 3,4] thiadiazol-2- ylidene) -cyclohexyl-amine Compound 140 was prepared by the procedure described - in example 115 (protocol D) using appropriate intermediates and reagents. The title product was isolated by chromatography on silica gel eluting with cyclohexane containing from 0 to 15% ethylacetate. Yield: 27% X H-NMR (400MHz, DMSO) δ PP™: 1.20-1.45 (m, 5H) , 1.60-1.70 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.70 (m, IH) , 3.50 (s, 3H) , 6.15 (s, 2H) , 7.00 (d, IH) , 7.15 (d, IH) , 7.25 (s, IH) MS (m/z) / M+l= 318 HPLC (uv purity, = 214 nm) : 99.9% \7 -T Example 141: Rl= cyclohexyl, R2= methyl, R3= 3,4,5- trimethoxyphenyl Cyclohexyl- [3-methyl-5- (3, 4, 5-trimethoxy-phenyl) -3H- [1,3,4] thiadiazol-2-ylidene] -amine Compound 141 was prepared by the procedure described in example 115 (protocol D) using appropriate intermediates and reagents . The title product was isolated by chromatography on silica gel eluting with heptane containing from 0 to 20% diethylether. Yield: 26% X H-NMR (400MHz, DMSO) δ ppm: 1.15-1.50 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.65-2.70 (m, IH) , 3.50 (s, 3H) , 3.70 (s, 3H) , 3.85 (s, 6H) , 6.90 (s, 2H) MS (m/z) / M+l= 364.49 HPLC (uv purity, λ= 214 nm) : 99.9% EXAMPLE I: PROTOCOL A Example 142 : Rl= cyclopentyl, R2= methyl, R3= 4-cyano- phenyl 4- (5-Cyclopentylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile To a suspension of 1,3,4-thiadiazolium perchlorate (3c) (0.86 mmol, 300 mg) in ethanol (20 ml), cyclopentylamine (1.03 mmol, 102 μl) and triethylamine (1.03 mmol, 264 μl) were added, and the mixture was stirred at reflux overnight. The mixture was concentrated by distillation of the solvent and the crude material was solubilized in ethyl acetate. The inorganic salts were removed by extraction with water. The organic layer was washed with water and a solution of NaCl, dried under magnesium sulphate, filtered, and distilled to give a residue which was chromatographed on silica gel column (using a gradient of solvent ethyl acetate- cyclohexane starting with a ratio 0/100 to 20/80) to isolate 210 mg of the pure product. Yield= 85.7% X H-NMR (400MHz, DMSO) δ ppm: 1.40-1.95 (m, 8H) , 3.15-3.25 (m, IH) , 3.50 (s, 3H) , 7.80 (dd, 2H) , 7.92 (dd, 2H) . MS (m/z) / M+l= 285 Example 143: Rl= cycloheptyl, R2 = methyl, R3= 4-cyanophenyl 4- (5-Cycloheptylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile The compound 143 was prepared by the procedure described in example 142 using the appropriate intermediates and reagents (protocol A) . The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 20% ethylacetate. Yield= 70.6% X H-NMR (400MHz, DMSO) δ PPm: 1.40-1.85 (m, 12H) , 2.75-2.85 (m, IH) , 3.50 (s, 3H) , 7.80 (dd, 2H) , 7.90 (dd, 2H) . MS (m/z) / M+l= 313 Example 144: Rl= 4-fluorophenyl, R2= Methyl, R3= 4-cyanophenyl 4- [5- (4-Fluoro-phenylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile The compound 144 was prepared by the procedure described in example 142 using the appropriate intermediates and reagents (protocol A) . The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 20% ethylacetate. Yield= 71.1% X H-NMR (400MHz, DMSO) δ PPm: 3.72 (s, 3H) , 7.03-7.10 (m, 2H) , 7.16-7.25 (m, 2H) , 7.83 (dd, 2H) , 7.93 (dd,2H). MS (m/z) / M+l= 311 Example 45: Rl= 3-phenol, R2= methyl, R3= 4-cyano-phenyl 4- ' [5- (3 -Hydroxy-phenylimino) -4-methy1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile The compound 145 was prepared by the procedure described in example 142 using the appropriate intermediates and reagents (protocol A) . The residue was purified by chromatography on silica gel eluting with a vzngradient of dichloromethane containing from 0 to 20% methanol. Yield = 99% X H-NMR (400MHz, DMSO) δ PP™: 3.70 (s, 3H) , 6.41-6.55 (m, 3H) , 7.15 (t, IH) , 7.82 (dd, 2H) , 7.91 (dd,2H), 9.42 (s, IH) . MS (m/z) / M+l= 309 Example 146: Rl= 4-fluoro-3 -benzoic acid, R2= methyl, R3= 4- cyano-phenyl 5- [5- (4-Cyano-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -2-fluoro-benzoic acid The compound 146 was prepared by the procedure described in example 142 using the appropriate intermediates and reagents (protocol A) . In this particular case, the residue was precipitated in ethylacetate to afford the pure product. Yield= 65.5% X H-NMR (400MHz, DMSO) δ PPm: 3.74 (s, 3H) , 7.24-7.37 (m, 3H) , 7.44-7.51 (m, IH) , 7.85 (dd, 2H) , 7.94 (dd,2H), 13.31 (b, IH) . MS (m/z) ' / M+l= 355 _ Example 147: Rl= 4-methyl-cyclohexyl, R2= methyl, R3= 4- cyano-phenyl I47a : 4- [4-Methyl-5- (cis-4-methyl-cyclohexylimino) -4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile I47b : 4- [4-Methyl-5- (trans-4-methyl-cyclohexylimino) -4,5- dihydro- [1,3,4] thiadiazol-2 -yl] -benzonitrile The compound 147 was prepared by the procedure described in example 142 using the appropriate intermediates and reagents (protocol A) . The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 20% ethylacetate to give the cis and trans isomers . Yield= 68.6% Compound cis: I47a \2 Z X H-NMR (400MHz, DMSO) PPm: 0.92 (d, 3H) , 1.38-1.68 (m, 9H) , 2.85-2.92 (m, IH) , 3.55 (a, 3H) , 7.80 (dd, 2H) , 7.92. (dd, 2H) . MS (m/z) / M+l= 313 Compound trans :I47b X H-NMR (400MHz, DMSO) δ ppm : 0.88 (d, 3H) , 0.94-1.09 (m, 2H) , 1.30-1.45 (m, 3H) , 1.64-1.83 (m, 4H) , 2.48-2.60 (m, IH) , 3.52 (a, 3H) , 7.80 (dd, 2H) , 7.92 (dd, 2H) MS (m/z) / M+l= 313 Example 148: Rl= trans-4-hydroxycyclohexyl, R2= methyl, R3= 4-cyano-phenyl 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methy1-4,5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile The compound 148 was prepared by the procedure described in example 142 using the appropriate intermediates and reagents (protocol A) . Using 0.86 mmol of thiadiazolium, an excess of trans-4-aminocyclohexanol hydrochloride (.7.7 mmol) and 8.6 mmol of triethylamine. The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing .from 0 to 30% ethylacetate. Yield= 74% X H-NMR (400MHz, DMSO) δ ppm: 1.18-1.42 (m,4H), 1.73-1.89 (m,4H) ' , 2.52-2.62 (m, IH) , 3.40-3.50 (m,.lH) , 3.53 (s, 3H) , 4.50 (s, IH) , 7.80 (dd, 2H) , 7.92 (dd, 2H) . MS (m/z) / M+l= 315 HPLC (uv purity, χ= 214 nm) = 99.9% Example 149: Rl= exo-2-norbornyl, R2= methyl, R3= 4-cyano- phenyl 4- [5- (Bicyclo [2.2.1] hept-2-ylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile The compound 149 was prepared by the procedure described in example 148 using the appropriate intermediates and reagents (protocol A) . The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 8% ethylacetate. 12-*=! Yield= 64% X H-NMR "(400MHz, DMSO) δ Ppm: 1.10-1.20 (m, 3H) , 1.26-1.35 (m, IH) , 1.40-1.53 (m, 2H) , 1.56-1.61 (m, IH) , 1.70-1.79 (m, IH) , 2.09-2.14 (m, IH) , 2.24-2.29 (m, IH) , 2.71-2.78 (m, IH), 3.52 (s, 3H) , 7.80 (dd, 2H) , 7.91 (dd, 2H) . MS (m/z) / M+l= 311 HPLC (uv purity, χ= 214 nm) = 99.2% Example 150: Rl= (IR*, 2R*) -2-hydroxy-cyclohexyl, R2= methyl, R3= 4-cyano-phenyl 4- [5- ( (IR*, 2R*) -2-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile The compound 150 was prepared by the procedure described in example 148 using the appropriate intermediates and reagents (protocol A) . The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 50% ethylacetate. Yield= 74% X H-NMR (400MHz, DMSO) δ pm: 1.15-1.40 (m, 5H) , 1.58-1.75 (m, 3H) , 1.80-1.90 (m, IH) , 2.38-2.49 (m, IH) , 3.30-3.40 (m, IH) , 3.55 (s, 3H) , 4.50 (a, IH) , 7.80 (dd, 2H) , 7.92 (dd, 2H) . MS (m/z) / M+l= 315 HPLC (uv purity, χ= 214 nm) = 99.9% Example 151: Rl= (IR*, 2S*) -2-hydroxycyclohexyl, R2= methyl, R3= 4-cyano-phenyl 4- [5- ( (IR*, 2S*) -2-Hydroxy-cyclohexylimino) -4-methyl-4,5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile Compound 151 waa prepared by the procedure described in example 142 using the appropriate intermediates and reagents (protocol A). 1,3,4-thiadiazolium perchlorate (0.287 mmol, 100 mg) in ethanol (6 ml) , cis-2-aminocyclohexanol hydrocloride (2.58 mmol, 390 mg) and triethylamine (2.87 mmol, 400 μl) were added. The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 30% ethylacetate. ll > 0 Yield= 72% X H-NMR (400MHz, DMSO) δ PPm: 1.15-1.80 (m, 8H) , 2.83-2.97 (m, IH) ,3.52-3.70 (m, 4H) , 4.10-4.20 (m, IH) , 7.80 (dd, 2H) , 7.94 (dd, 2H) . MS (m/z) / M+l= 315 HPLC (uv purity, = 214 nm) = 98.7% Examples 152-a and 152-b : Rl= 3 -hydroxycyclohexyl, R2= methyl, R3= 4-cyano-phenyl I52-a: 4-[5-((lR*, 3R*) -3-Hydroxy-cyclohexylimino) -4-methyl- 4, 5-dihydro- [1, 3,4] thiadiazol-2 -yl] -benzonitrile I52-b: 4-r [5- ( (IR*, 3S*) -3-Hydroxy-cyclohexylimino) -4-methyl- 4, 5-dihydro- [1, 3,4] thiadiazol-2 -yl] -benzonitrile The compounds 152 -a and 152 -b were prepared by the procedure described in example 142 using the appropriate intermediates and reagents (protocol A). A mixture of 1,3,4-thiadiazolium perchlorate (3c) (3.5 mmol, 1.22 g) in ethanol (80 ml), racemic-3-aminocyclohexanol (4.2 mmol, 485 mg) and triethylamine (4.2 mmol, 587 μl) was stirred at reflux during 4H. The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 60% ethylacetate to give 120 mg of the trans isomer and 260 mg cis isomer. IR*, 3R* isomer (I52a) Yield = 11%. X H-NMR (400MHz, DMSO) δ PP™: 1.35-1.50 (m, 2H) , 1.50-1.70 (m, 6H) ,3.04-3.12 (m, IH) , 3.54 (s, 3H) , 3.88-3.96 (m, IH) , 4.44 (d, IH) , 7.80 (dd, 2H) , 7.94 (dd, 2H) . IR*, 3S* isomer (I52b) X H (400MHz, DMSO) δ ppm: 1.03-1.30 (m, 4H) , 1.64-1.78 (m, 2H) ,1.78-1.87 (m, IH) , 1.98-2.04 (m, IH) , 2.58-2.70 (m, IH) , 3.40-3.58 (m, 4H) , 4.61 (s, IH) , 7.44 (s, IH) , 7.70 (dd, 2H) , 7.95 (dd, 2H) , 8.07 (s, IH) . • Example 153: Rl= (IR*, 3R*) -3 -hydroxy-cyclohexyl, R2= methyl, R3= 4- (methylsulfonyl) phenyl 1 * 3/ (IR*, 3R*) ) -3- [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol The compound 153 was prepared by the procedure described in example 142 using the' appropriate intermediates and reagents (protocol A). A mixture of 1,3,4-thiadiazolium perchlorate (3b) (1 mmol, 400 mg) , ethanol (25 ml) , 3 -aminocyclohexanol (1.2 mmol, 140 mg) and triethylamine (2.5 mmol, 350 μl) was stirred at reflux during 3H. The residue was purified by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 50% ethylacetate. The product was then purified by HPLC on Kromasil C18 column with a gradient of acetonitrile/water 95/5 to 5/95 to give the pure product . Yield= 10% X H-NMR (400MHz, DMSO) δ P ™: 1.30-1.69 (m, 8H) , 3.00-3.10 (m, IH) , 3.21 (s, 3H) , 3.52 (a, 3H) , 3.82-3.95 (m, IH) , 4.35 (d, IH) , 7.85 (dd, ' 2H) , 7.98 (dd, 2H) MS (m/z) / M+l= 367/369 HPLC (uv purity, χ= 214 nm) = 98.9% Example 154: Rl= (IR*, 3R*) -3 -Hydroxy-cyclohexyl, R2= methyl, R3= 4-benzoic acid 4- [5- (IR*, 3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzoic acid To a solution of I52a (3.18 mmol, 1 g) in isopropanol (20ml), a solution of KOH [6N] (15.9 mmol, 2.6 ml) was added and the mixture was stirred at reflux during 4 days. The mixture was acidified to pH= 6-7 with a solution of HCl and concentrated under reduced pressure to give the carboxylic acid derivative 154. IH (400MHz, DMSO) δ PPm : 1.32-1.70 (m, 8H) , 3.03-3.12 (m, IH) , 3.50 (s, 3H) , 3.85-3.95 (m, IH) , 4.35-4.50 (m, IH) , 7.75 (dd, 2H) , 8.00 (dd,2H), 13.15 (s, IH) Example 155: Rl= (IR*, 3R*) -3-hydroxycyclohexyl, R2= methyl, R3= 4- [N- (2-morpholin-4-yl-ethyl) ] benzamide 4- [5- ( (IR*, 3R*) -3-hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -N- (2-morpholin-4-yl-ethyl) - benzamide Compound 155 was prepared by the procedure described in exemple 137.11 using 154 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 4% methanol, to give the desired product. Yield: 14% X H-NMR ( 400MHz, DMSO): δ PP™: 1.35-1.70 (m, 8H) , 2.35-2.52 (m, 6H) , 3.02-3.12 (m, IH) , 3.32-3.45 (m, 2H) , 3.50-3.62 (m, 7H) , 3.88-3.95 (m, IH) , 4.40 (d, IH) 7.72 ' (dd, 2H) , 7.92 (dd, 2H) , 8.50 (a, IH) . MS (m/z) / M+l= 446 HPLC (uv purity, λ= 214 nm) = 96.6% Example 156: Rl= trans-4-hydroxycyclohexyl, R2 = methyl, R3= 4-benzoic acid 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methy1-4, 5-dihydro- [1, 3,4] thiadiazol-2-yl] -benzoic acid To a solution of 148 (1.9 mmol, 600 mg) in ethanol (15 ml) and isopropanol (15 ml), a solution of KOH [6N] (5.7 mmol, ' 960 μl) was added and stirred at reflux during 7H. The mixture was acidified to pH = 6-7 with a solution of HCl ' -and then concentrated under reduced to give the carboxylic acid derivative 156. X H-RMN (400MHz, DMSO) δ PPm: 1.22-1.32 (m, 2H) , 1.60-1.80 (b, 2H) , 1.90-2.04 (m, 4H) , 3.41-3.50 (m, IH) , 4.00 (a, 3H) , 7.80-7.90 (m, 2H) , 8.00-8.10 (m, 2H) , 11.00 (s, IH) . Example 157: Rl= trans-4-hydroxy-cyclohexyl, R2= methyl, R3= 4- (N-2-hydroxy-l,l-dimethyl-ethyl)benzamide 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl] -N- (2-hydroxy-l, 1-dimethyl-ethyl) - benzamide Compound 157 was prepared by the procedure described in exemple 137.11 using 156 as a starting material. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 9% methanol, to give the expected product . Yield: 20% X H-NMR (400MHz, DMSO): δ PP™: 1.15-1.45 (m, 10H) , 1.70-1.90 (m, 4H) , 2.50-2.60 (m, IH) , 3.40-3.55 (m, 6H) , 4.50 (d, IH) 4.85 (d, IH) , 7.60 (s, IH) , 7.70 (dd, 2H) , 7.89 (dd, 2H) . MS (m/z) / M+l= 405 HPLC (uv purity, χ= 214 nm) = 99.9% Example 58: Rl= (IR*, 3R*) -3-hydroxy-cyclohexyl, R2= methyl, R3= 4- (N-2 -hydroxy-1, 1-dimethyl-ethyl) benzamide 4- [5- ( (IR*, 3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -N- (2 -hydroxy-1, 1-dimethyl- ethyl) -benzamide Compound 158 was prepared by the procedure described in example 155 using appropriate intermediates and reagents (154 and 1, l-dimethyl-2-ethanolamine) . The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 5% methanol, to give the desired product. Yield: 58% X H-NMR (400MHz, DMSO): δ PP™: 1.20-1.70 (m, 14H) , 3.02-3.12 (m, IH) , 3.40-3.60 ( , 5H) , 3.85-3.95 (m, IH) , 4.40 (d, IH) , 4.85 (d, IH) , 7.60 (s, IH) , 7.68 (dd, 2H) , 7.85 (dd, 2H) MS (m/z) / M+l= 405 HPLC (uv purity, λ= 214 nm) = 94.4% Example 159: (IR*, 3R*) -3-hydroxycyclohexyl, R2= methyl, R3= 4- (N-tert-butyl) -benzamide N-tert-Butyl-4- [5- ( (IR*, 3R*) -3-hydroxy-cyclohexylimino) -4- ethy1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide Compound 159 was prepared by the procedure described in example 155 using appropriate intermediates and reagents (154 and isobutylamine) . The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 10%. Yield: 33% X H-NMR (400MHz, DMSO): δ ppm: 1.30-1.70 (m, 17H) , 3.02-3.12 (m, IH) , 3.50 (s, 3H) , 3.85-3.95 (m, IH) , 4.40 (d, IH) , 7.68 (dd, 2H) , 7.80-7.90 (m, 3H) . MS (m/z) / M+l= 389 HPLC (uv purity, λ= 214 nm) = 94.1% Example 160: Rl= (IR*, 3R*) -3-hydroxy-cyclohexyl, R2= methyl, R3= 4- [N- (1, 1-dimethyl-3 -oxo-butyl) ] -benzamide N- (l,l-dimethyl-3-oxo-butyl)-4- [5- (IR*, 3R*) -3-hydroxy- cyclohexylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 - yl] -benzamide To a suspension of diacetoamine hydrogenoxalate (3 mmol, 616 mg) in DMF (6 ml) under nitrogen atmosphere, morpholine resin [3.47 mmol/g] (7 mmol, 2 g) was added, and the mixture was stirred at room temperature during 30 minutes and then filtered. A mixture of acid 154 (0.6 mmol), the filtrate, N,N-diisopropylethylamine(1.32 * mmol, 227 μl) , benzotriazol- 1-yloxytris (dimethylamino) phosphonium ' hexafluorophosphate (0.72 mmol, 318 mg) , 1-hydroxy-7-azabenzotriazole (0.3 mmol, 82 mg) was stirred at room temperature during 4H. The mixture was concentrated and then diluted in dichloromethane . The organic layer was washed with a satured solution of ammonium chloride, a satured solution of NaHC0 3 , with water, brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography using a gradient of dichloromethane containing 0 to 8% methanol. The compound was purified by HPLC ( Kromasil C18 column) eluting with acetonitrile/water 95/5 to 5/95 to give the desired product. Yield: 10% X H-NMR ( 400MHz, DMSO): δ Ppm: 1.30-1.70 (m, 14H) , 2.05 (s, 3H) , 2.92-3.10 (m, 3H) , 3.50 (s, 3H) , 3.85-3.95 (m, IH) , 4.40 (d, IH) , 7.68 (dd, 2H) , 7.85 (dd, 2H) , 7.95 (s, IH) . MS (m/z) / M+l= 431 HPLC (uv purity, χ= 214 nm) = 99.3% Example 161: Rl= (1R*,3R*) -3 -hydroxy-cyclohexyl, R2= methyl, R3= 4- [N- (2-cyano-l,2,2-trimethyl-ethyl) ] -benzamide N- (2-Cyano-l,2,2-trimethyl-ethyl) -4- [5- ( (IR*, 3R*) -3- hydroxy-cyclohexylimino) -4-methy1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide Compound 161 was prepared by the procedure described in example 155 using appropriate intermediates and reagents (154 and 2-amino-2 , 3-dimethylbutanenitrile) . The residue was purified by silica gel chromatography using a gradient of cyclohexane containing 0 to 70% ethylacetate, to give the title product . Yield: 8% X H-NMR ( 400MHz, DMSO): δ PP™= 0.95 (d, 3H) , 1.10 (d, 3H) , 1.30-1.70 (m, 11H) , 2.45-2.65 (m, IH) , 3.00-3.10 (m, IH) , 3.50 (s, 3H) , 3.85-3.95 (m, IH) , 4.40 (d, IH) , 7.70 (dd, 2H) , 7.90 (d, 2H) , 8.65 (s, IH) . MS (m/z) / M+l= 428 HPLC (uv purity, λ= 214 nm) = 99.4% Example 162: Rl= (IR*, 3R*) -3 -hydroxy-cyclohexyl, R2= methyl, R3= 4- (N-1-methoxycarbonyl-cyclopropylk-benzamide l-{4- [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzoylamino} - cyclopropanecarboxylic acid methyl ester Compound 162 was prepared by the procedure described in example 137.24 using appropriate intermediates and reagents (155 and 1-aminocyclopropane-l-carboxylic acid, methylester hydrochloride) The residue was purified once by silica gel chromatography using a gradient of dichloromethane containing 0 to 10% methanol and by HPLC (Hypersil Column) with a gradient acetonitrile/water 95/5 to 5/95 to afford the desired product . Yield: 32% X H-NMR (400MHz, DMSO): δ Ppm: 1.12-1.20 (m, 2H) , 1.33-1.50 (m, 4H) , 1.50-1.70 (m, 6H) , 3.03-3.12 (m, IH) , 3.52 (s, 3H) , 13k 3 . 60 (s , IH) , 3 . 89 -3 . 98 (m, IH) , 4 .40 (d, IH) , 7 . 72 (dd, 2H) , 7 . 94 (d , 2H) , 9 . 17 ( s , IH) . MS (m/ z) / M+l= 431 HPLC (uv purity, λ= 214 nm) = 97.9% Example 163: Rl= cyclopentyl, R2= methyl, R3= 4-benzamide 4- (5-Cyclopentylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide To a solution of compound 142 (0.53 mmol, 150 mg) in ethanol (17 ml), a solution of Na 2 C0 3 [3N] (5.6 mmol, 1.88 ml) and a solution of H 2 0 at 30% in water (1.54 ml) were added. The solution was stirred overnight at room temperature. To the mixture, was added a solution of H 2 0 at 30% in water (770 μl) and the solution was allowed to stir at room temperature during two days (reaction to completion) . The resultant mixture was concentrated by distillation of the solvent and the crude material was precipitated in water. The precipitate was filtered off, washed several times with water and dried to give the pure product . Yield= 53.4% X H-NMR (400MHz, DMSO) δ PP™: 1.43-1.95 (m, 8H) , 3.18-3.28 (m, IH) , 3.52 (s, 3H) , 7.44 (s, IH) , 7.70 (dd, 2H) , 7.95 (dd,2H) , 8.05 (s, IH) . MS (m/z) / M+l= 303 HPLC (uv purity, λ= 214 nm) = 98.04% Example 164: Rl= cycloheptyl, R2= methyl, R3= 4-benzamide 4- (5-Cycloheptylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide Compound 164 was prepared by the procedure described in example 163 using appropriate intermediates (143) and reagents . The precipitate was filtered, washed several times with water and dried to give the pure product . Yield= 59.88% X H-NMR (400MHz, DMSO) δ PPm: 1.40-1.83 (m, 12H) , 2.78-2.85 (m, IH) , 3.52 (s, 3H) , 7.44 (s, IH) , 7.72 (dd, 2H) , 7.97 (dd,2H) , 8.07 (s, IH) . MS (m/z) / M+l= 331 HPLC (uv purity, λ= " 214 nm) = 98.98% Example 165: Rl= 4-fluoro-phenyl, R2= methyl, R3= 4- benzamide 4- [5- (4-Fluoro-phenylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl] -benzamide Compound 165 was prepared by the procedure described in example 163 using appropriate intermediates 144 and reagents. The precipitate was filtered, washed several times with water and dried to give the pure product . Yield= 72.43% X H-NMR (400MHz, DMSO) δ PP™: 3.72 (s, 3H) , 7.02-7.40 (m, 2H) , 7.15-7.24 (m, 2H) , 7.44 (s, IH) , 7.72 (dd, 2H) , 7.95 (dd,2H) , 8.05 (s, IH) . MS (m/z) / M+l= 329 HPLC (uv purity, λ= 214 nm) = 97.7% Example 166: Rl= 3-hydroxy-phenyl, R2= methyl, R3= 4- benzamide 4- [5- (3-Hydroxy-phenylimino) -4-methyl-4,5-dihydro- [1,3,4] hiadiazol-2-yl] -benzamide Compound 166 was prepared by the procedure described in example 163 using appropriate intermediates (145) and reagents . The precipitate was filtered, washed several times with water and dried to give the pure product . Yield= 59.84% X H-NMR (400MHz, DMSO) δ PPm: 3.70 (s, 3H) , 6.44-6.52 (m, 3H) , 7.18 (t, IH) , 7.44 (s, IH) , 7.75 (dd, 2H) , 7.97 (dd, 2H) , 8.06 (s, IH) , 9.40 (a, IH) . MS (m/z) / M+l= 327 HPLC (uv purity, χ= 214 nm) = 99.68% Example 167: Rl= 4-fluoro-3 -benzoic acid, R2= methyl, R3= 4- benzamide 5- [5- (4-Carbamoyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -2-fluoro-benzoic acid Compound 167 was prepared by the procedure described in example 163 using appropriate intermediate (146) and reagents . The precipitate was filtered, washed several times with water and dried to give the pure product. Yield= 44.41% X H-NMR (400MHz, DMSO) δ PPm: 3.72 (a, 3H) , 7.25-7.32 (m, 2H) , 7.43-7.50 (m, 2H) , 7.78 (dd, 2H) , 7.95 (dd, 2H) , 8.05 (s, IH) , 13.30 (b, IH) . MS (m/z) / M+l= 373 HPLC (uv purity, = 214 nm) = 90.52% Example 168: Rl= trans-4-methyl-cyclohexyl, R2= methyl, R3= 4-benzamide 4- [4-Methyl-5- (trans-4-methyl-cyclohexylimino) -4, 5-dihydro- [1,3,4] thiadiazol- -yl] -benzamide Compound 168 was prepared by the procedure described in example 163 using appropriate intermediates (I47b) and reagents . The precipitate was filtered, washed several times with water and dried to give the pure product. Yield= 52.53% X H-NMR (400MHz, DMSO) δ Ppm: 0.90 (d, 3H) , 0.95-1.08 (m, 2H) , 1.30-1.45 (m, 3H) , 1.67-1.85 (m, 4H) , 2.50-2.60 (m, IH) , 3.52 (s, 3H) , 7.44 (s, IH) , 7.72 (dd, 2H) , 7.95 (dd, 2H) , 8.05 (S, IH) . MS (m/z) / M+l= 331 HPLC (uv purity, λ= 214 nm) = 99.7% Example 169: Rl= trans-4-hydroxy-cyclohexyl, R2= methyl, R3= 4-benzamide i > 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide To a suspension of 148 (0.477 mmol, 150 mg) in ethanol (17 ml), a solution of Na 2 C0 3 [3N] (5.1 mmol, 1.7 ml) and a solution of H 2 0 2 at 30% in water (1.4 ml) were added and the mixture was stirred overnight at room temperature. This mixture was poured into water before extraction with ethyl acetate. The organic layer was washed with water and with a saturated solution of NaCl, dried over magnesium sulfate, filtered and distilled to give a residue wich was purified by silica gel chromatography (eluted with a gradient of dichloromethane/methanol 100/0 to 98/2) to afford the pure product . Yield= 31% X H-NMR (400MHz, DMSO) δ PP™: 1.20-1.42 (m, 4H) , 1.75-1.90 (m, 4H) , 2.50-2.63 (m, IH) , 3.40-3.52 (m, IH) , 3.50 (s, 3H) , 4.55 (s,lH), 7.44 (s, IH) , 7.72 (dd, 2H) , 7.98 (dd, 2H) , 8.07 (s, IH) . MS (m/z) / M+l= 332/333 HPLC (uv purity, λ= 214 nm) = 97.3% Example 170: Rl= bicyclo [2.2.1] hept-2-yl, R2= methyl, R3= 4- benzamide 4- [5- (Bicyclo [2.2.1] hept-2-ylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide Compound 170 was prepared by the procedure described in example 169 using appropriate intermediates (149) and reagents. The residue was purified by silica gel chromatography (eluted with a gradient of dichloromethane/methanol 100/0 to 90/10) to afford the desired product. Yield= 66% X H-NMR (400MHz, DMSO) ppm: 1.10-1.25 (m, 3H) , 1.28-1.40 (m,lH), 1.40-1.67 (m, 4H) , 2.10-2.18 (m, IH) , 2.25-2.32 (m,lH), (2.70-2.80 ( , IH) , 3.52 (s, 3H) , 7.50 (s, IH) , 7.72 (dd, 2H) , 7.97 (dd, 2H) , 8.10 (s, IH) . MS (m/z) / M+l= 329 HPLC (uv purity, λ= 214 nm) = 99.9% Example 71: Rl= (IR*, 2R*) -2-hydroxy-cyclohexyl, R2= methyl, R3= 4-benzamide 4- [5- ( (1R*,2R*) -2 -hydroxy-cyclohexylimino) -4-methy1-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzamide Compound 171 was prepared by the procedure described in example 169 using appropriate intermediates (150) and reagents. The residue was purified by silica gel chromatography (eluted with a gradient of dichloromethane/methanol 100/0 to 90/10) to afford the pure product. Yield= 44% X H-NMR (400MHz, DMSO) δ PP™: 1.20-1.39 (m, 4H) , 1.60-1.75 (m, 3H) , 1.80-1.90 (m, IH) , 2.35-2.45 (m, IH) , 3.50 (s, 3H) , 4.55 (S,1H), 7.50 (s, IH) , 7.72 (dd, 2H) , 7.96 (dd, 2H) , 8.05 (S, IH) . MS (m/z) / M+l=333 HPLC (uv purity, χ= 214 nm) = 97.4% Example 172: Rl= (IR*, 2S*) -2-hydroxy-cyclohexyl, R2= methyl, R3= 4-benzamide 4- [5- ( (1R*,2S*) -2-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2 -yl] -benzamide To a suspension of 151 (0.16 mmol, 50 mg) in DMSO (100 μl) , K 2 C0 3 (0.022 mmol, 3 mg) , a solution of H 2 0 at 30% in water (20 μl) was added and the mixture was stirred overnight at room temperature. To this mixture, water was added and the solution was allowed to stir 15 minutes. The precipitate was filtered off and dried under reduced pressure to give the desired product . " - Yield= 68% X H-NMR (400MHz, DMSO) ppm: 1.25-1.38 (m, 2H) , 1.40-1.80 (m, 6H) , 2.85-2.90 (m, IH) , 3.57 (s, 3H) , 3.60-3.68 (m, IH) , 4.10 (d,lH), 7.40 (s, IH) , 7.70 (dd, 2H) , 7.95 (dd, 2H) , 8.05 (s, IH) . MS (m/z) / M+l= 333 HPLC (uv purity, λ= 214 nm) = 98.8% Example 173: Rl= (IR*, 3R*) -3-hydroxy-cyclohexyl, R2= methyl, R3= 4-benzamide 4- [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzamide Compound 173 was prepared by the procedure described in example 169 using appropriate intermediates (I52-a) and reagents. The mixture waa concentrated under reduced pressure and stirred in water several hours, filtered and dried under vaccum to afford the desired product. Yield= 70% H-NMR (400MHz, DMSO) δ PP™: 1.30-1.70 (m, 8H) , 3.10 (s, IH) , 3.52 (a, 3H) , 3.93 (s,lH), 4.42 (d, IH) , 7.43 (s, IH) , 7.70 (dd, 2H) , 7.96 (dd,2H), 8.05 (s, IH) . MS (m/z) / M+l=333 HPLC (uv purity, λ= 214 nm) = 98.3% Example 174: Rl= (1R*,3S*) -3 -hydroxy-cyclohexyl, R2= methyl, R3= 4-benzamide 4- [5- ( (1R*,3S*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzamide Compound 174 was prepared by the procedure described in example 169 using appropriate intermediates (I52-b) and reagents. The mixture was concentrated under reduced pressure and stirred in water several hours, filtered and dried under vaccum to afford the desired product. Yield= 83% X H-NMR (400MHz, DMSO) δ PPm= 1.05-1.30 (m, 4H) , 1.65-1.78 (m,. 2H) , 1.78-1.88 (m, IH) , 1.95-2.05 (m, IH) , 3.40-3.58 (m, 4H) , 4.60 (s, IH) , 7.45 (s, IH) , 7.70 (dd, 2H) , 7.95 (dd, 2H) , 8.05 (s, IH) . MS (m/z) / M+l=333 HPLC (uv purity, χ= 214 nm) = 99.4% Example 174.1: Rl= 3-oxo-cyclohexyl, R2= methyl, R3= 4- benzamide 4- [4-Methyl-5- (3 -oxo-cyclohexylimino) -4, 5-dihydro- [1,3,4] thiadiazol-2 -yl] -benzamide To a solution of 174 (0.15 mmol, 50 mg) in dichloromethane (0.5 ml), tetrapropylammoniumperruthenate (0.5% mol, 3 mg) , 4-methylmorpholine-N-oxide (0.22 mmol, 28 mg) and molecular sieve (500 mg/mol , 75 mg) were added and the mixture was stirred at room temperature overnight. The mixture was filtered through a pad of silica gel (eluted with dichloromethane/methanol 100/0 to 95/5) , the filtrate was concentrated under reduced pressure and washed with diethylether to afford the pure product. Yield= 18% X H-NMR (400MHz, DMSO) δ PPm: 1.63-1.82 (m, 2H) , 1.89-2.10 (m, 2H) , 2.21-2.50 (m, 4H) , 3.15-3.30 (m, IH) , 3.52 (a, 3H) , 7.45 (s, IH) , 7.70 (dd, 2H) , 7.98 (dd, 2H) , 8.08 (s, IH) . MS (m/z) / M+l=331 HPLC (uv purity, λ= 214 nm) = 98.7% Example 175: Rl= 3, 3-difluoro-cyclohexyl, R2= methyl, R3= 4- benzamide 4- [5- (3,3-Difluoro-cyclohexylimino) -4-me hyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide To a solution of I52-b (0.318 mmol, 100 mg) in dichloromethane (1 ml) was added tetrapropylammonium perruthenate (0.5 %mol,6 mg) , 4-methylmorpholine-N-oxide (0.477 mmol, 56 mg) and molecular sieve (500 mg/mol, 160 mg) . The mixture was stirred at room temperature for 3H, filtered through silica gel (eluted with cyclohexane/ethyl acetate 100/0 to 60/40) and concentrated under reduced pressure to afford " 4- [4-Methyl-5- (3-oxo-cyclohexylimino) - 4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile Yield = 90% X H-NMR (400MHz, DMSO) δ Pm: 1.60-1.80 (m, 2H) , 1.87-2.10 (m, 2H) , 2.21-2.30 (m, 3H) , 2.55-2.60 (m, IH) , 3.15 (s, IH) , 3.52 (s, 3H) , 7.82 (dd, 2H) , 7.92 (dd, 2H) . To a solution of this ketone (0.288 mmol, 90 mg) in dichloromethane (0.5 ml), a solution of deoxo-fluor (0.49 mmol, 90 μl) in dichloromethane (1 ml) and ethanol (0.346 mmol, 5 μl) was added and the mixture was stirred overnight at room temperature . The mixture was poured into a satured solution of NaHC03 (pH=7) , and the aqueous layer was extrated with dichloromethane. The organic layer was washed with water and brine, dried with magnesium sulfate, filtered and concentrated under reduced pressure to give a residue wich was purified by silica gel chromatography (eluted with a gradient of cyclohexane/ethyl acetate 100/0 to 80/20) to afford the pure di-fluoro compound : 4- [5- (3 , 3-Difluoro- cyclohexylimino) -4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol-2- yl] -benzonitrile Yield = 12% X H-RMN (400MHz, DMSO) δ PPm: 1.40-1.55 (m, 2H) , 1.78-1.90 (m, 4H) , 1.95-2.09 (m, IH) , 2.15-2.28 (m, IH) , 2.80-2.90 (m, IH) , 3.55 (s, 3H) , 7.82 (dd, 2H) , 7.92 (dd, To a solution of this di-fluoro derivative (0.036 mmol, 12 mg) in ethanol (1.6 ml) a solution of Na 2 C0 3 [3N] (0.6 mmol, 200 μl) , and a solution of H 2 0 2 at 30% in water (150μl) were added and the mixture was stirred at 40°C overnight. Then, a solution of H 2 0 2 at 30% in water (130 μl) was added and the solution was allowed to stir 12 h at 40 °C The mixture was concentrated under reduced pressure. The residue was stirred in water several hours, filtered, washed with ether and dried under vaccum to give the desired compound. Yield= 40% X H-NMR (400MHz,- DMSO) δ ppm: 1.33-1.53 (m, 2H) , 1.70-1.90 (m, 4H) , 1.90-2.05 (m, IH) , 2.15-2.28 ( , IH) , 2.80-2.90 (m, IH) , 3.55 (s, 3H) , 7.48 (s, IH) , 7.72 (dd, 2H) , 7.96 (dd, 2H) , 8.08 (s, IH) MS (m/z) / M+l=353 HPLC (uv purity, λ = 214 nm) = 98.7% Example 176: Rl= (IR*, 3R*) -3-fluoro-cyclohexyl, R2= methyl, R3= 4-benzamide 4- [5- ( (1R*,3R*) -3-Fluoro-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2 -yl] -benzamide To a solution of I52-b (1.59 mmol, 500 mg) in dichloromethane (4 ml), 4-morpholinisulfurtrifluoride (3.18 mmol, 390 μl) was added at -15°C dropwise under nitrogen atmosphere. The mixture was warmed at room temperature during 30 minutes and poured into a saturated solution of NaHC0 3 (pH=7) . The aqueous phase was extracted with dichloromethane. The organic layer was washed with water and brine, dried over magnesium sulfate, filtered and concentrated under reduce pressure to give a residue wich was purified by " silica gel chromatography (eluted with a gradient of cyclohexane/ethyl acetate 100/0 to 70/30) to afford 4- [5- (Cyclohex-3-enylimino) -4-methyl-4, 5-dihydro- tl, 3 , 4] thiadiazol-2-yl] -benzonitrile and a mono-fluoro intermediate (4- [5- ( (trans) -3-Fluoro-cyclohexylimino) -4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile) : Yield= .14% X H-NMR (400MHz, DMSO) δ PPm: 1.40-1.50 (m, IH) , 1.58-1.85 (m, 6H) , 1.92-2.05 (m, IH) , 2.95-3.05 (m, IH) , 3.55 (s, 3H) , 4.95 (d, IH) , 7.83 (dd, 2H) , 7.95 (dd, 2H) . To a solution of this fluoro intermediate (0.2 mmol, 65 mg) in ethanol (8.7 ml) a solution of Na 2 C0 3 [3N] (2.61 mmol, 870 μl) and a solution of H 2 0 2 at 30% in water (705 μl) were added and the mixture was stirred overnight at 40°C A aolution of H 2 0 2 at 30% in water (705 μl) was added and the reaction was. allowed to stir for lOh at 40 °C The mixture was concentrated under reduced pressure. The residue was stirred in water several hours, filtered, washed with ether and dried under vaccum to give the title product 176. Yield= 58% X H-NMR (400MHz, DMSO) PP™: 1.35-1.52 (m, IH) , 1.52-1.90 (m, 6H) , 1.90-2.08 (m, IH) , 2.93-3.08 (m, IH) , 3.55 (s, 3H) , 5 . 00 (d, IH) , 7 . 50 (s , IH) , 7 . 78 (dd, 2H) , 7 . 99 (dd, 2H) , 8 . 10 (s , IH) . MS (m/z) / M+l= 335 HPLC (uv purity, λ= 214 nm) = 96.6% Example 177: Rl= 3-cyclohexene, R2= methyl, R3= 4-benzamide 4- [5- (Cyclohex-3-enylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide To a solution of 4- [5- (Cyclohex-3-enylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile from protocol 176 (0.94 mmol, 280 mg) in ethanol (41 ml), a solution of Na 2 C0 3 , [3N] (12.3 . mmol, 4.1 ml), and a solution of H 2 0 2 at 30% in water (3.33 ml) were added. The mixture was stirred overnight at room temperature and concentrated under reduced pressure. The residue was stirred in water several hours, filtered, and dried under vaccum to afford the pure product. Yield= 64% X H-NMR (400MHz, DMSO) δ PPm: 1.48-1.65 (m, IH) , 1.72-2.35 (m, 5H) , 2.82-2.92 (m, IH) , 3.55 (s, 3H) , 5.65 (t, 2H) , 7.50 (s, IH) , 7.71 (dd, 2H) , 7.95 (dd, 2H) , 8.09 (a, IH) MS (m/z) / M+l= 315 ■ . ' HPLC (uv purity, λ= 214 nm) = 96.1% Example 178: Rl= (IR*, 3R*) -3 -hydroxy-cyclohexyl, R2= methyl, R3= 4- (lH-tetrazol-5-yl) -phenyl (1R*,3R*) -3-{3-Methyl-5- [4- (lH-tetrazol-5-yl) -phenyl] -3H- [1,3,4] thiadiazol-2 -ylideneamino}-cyclohexanol To a solution of 152 -a (1.27 mmol, 400 mg) in toluene (3 ml), sodium azide (1.65 mmol, 108 mg) and triethylamine hydrochloride (1.65 mmol, 228 mg) were added and the mixture was warmed at reflux during 24 hours. The reaction mixture was cooled at room temperature, acidified with a solution of HCl ' [0.1N], and then basified at pH=6-7 with a saturated solution of NaHC0 3 . The aqueous phase was extracted with dichloromethane and the organic layer was washed with a saturated solution of NaCl, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was chromatographed on silica gel column using a gradient of dichloromethane containing from 0 to 20% methanol to afford the title compound. Yield: 50% X H-NMR ( 400MHz, DMSO): δ P m: 1.30-1.70 (m, 8H) , 3.00-3.15 (m, IH) , 3.50 (s, 3H) , 3.85-3.98 (m, IH) , 4.40 (s, IH) , 7.75 (dd, 2H) , 8.10 (d, 2H) . MS (m/z) / M+l= 358 HPLC (uv purity, χ= 214 nm) = 99.9% Example 179: Rl= 3- (6-hydroxy) -benzoic acid, R2= methyl, R3= 4-chloro-phenyl 3- [5- (4-Chloro-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -2-hydroxy-benzoic acid The title compound was prepared by the procedure desribed in example 13 using ethanol as solvent and appropriate intermediates and reagents . The residue was twice chromatographed on silica gel eluting with dichloromethane containing from 0 to 7% of methanol. The isolated product was washed with water to afford the desired product. Yield= 9.7% X H-NMR (400MHz, DMSO) δ PPm: 3.62 (s, 3H) , 6.80 (t, IH) , 7.12 (d, IH) , 7.40-7.46 (m, 3H) , 7.59 (d, 2H) . MS (m/z) / M+l =362/364. HPLC (uv purity, λ= 214 nm) : 98.36% Example 180 : Rl= 3-benzoic acid, R2= methyl, R3= 4-cyano- phenyl 3- [5- (4-cyano-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid A auapension of 1,3,4-thiadiazolium perchlorate (3c) (4.873 mmol, 1.70 g) , 3-aminobenzoic acid (4.87 mmol, 0.668 g) and triethylamine (4.873 mmol, 0.679 ml) in ethanol (20 ml) was refluxed for 3.5h. On cooling, the solid formed was filtered off and washed with cold EtOH and ether. The solid was dried under reduced pressure to give 1.25 g of the expected compound. I Lv " 7 Yield= 76 . 2 % X H-NMR (400MHz, DMSO) δ PPm: 3.87 (s, 3H) , 7.39-7.42 (m, IH) , 7.60-7.65 (m, IH) , 7.70 (s, IH) , 7.78-7.82 (m, IH) , 7.96-8.00 (d, 2H) , 8.00-8.04 (d, 2H) . MS (m/z) / M+l = 337/338 HPLC (uv purity, λ= 214 nm) = 93.22% Example 180.1: Rl= 3-benzoic acid, R2= methyl, R3= 4- benzamide 3- [5- (4-carbamoyl-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2 - ylideneamino] -benzoic acid Concentrated sulfuric acid (19.8 mmol, 1.06 ml) and water (0.13 ml) were respectively added, at 0°C, to 180 (0.595 mmol, 0.200 g) .and the reaction mixture was heated at 80°C for lh30. Then, ice was added to the mixture and the formed precipitate was filtered off and purified by chromatography on silica gel, eluting with a mixture of acetic acid/dicloromethane/methanol (1.5/85/13.5). The isolated product was triturated in methanol and the solid was filtered off and dried under vaccum to give the title product . Yield=34% X H-NMR (400MHz, DMSO) δ PPm: 3.76 (s, 3H) , 7.30 (d, IH) , 7.46-7.55 (m, 2H) , 7.62 (s, IH) , 7.67 (d, IH) , 7.80 (d, 2H) , 7.99 (d, 2H) , 8.09 (s, IH) , 12.90-13.02 (d, IH) . MS (m/z) / M+l= 355/356 HPLC (uv purity, λ= 214 nm) : 96.37% Example 181: Rl= 4-fluoro-3-benzoic acid, R2= methyl, R3= 4- (methylsulfonyl) -phenyl 2-Fluoro-5- [5- (4-methanesulfonyl-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzoic acid 181 was prepared by the procedure described in example 14 (protocol A) with the appropriate reagents and using 1.0 eq of triethylamine. The reaction mixture was concentrated and the residue was purified by silica gel chromatography 1 1+% eluting with dichloromethane and then a mixture of dichloromethane/ MeOH/AcOH (98 /1.8 /0.2). Yield= 13% X H-NMR (400MHz, DMSO) δ ppm: 3.19 (s, 3H) , 3.57 (s, 3H) , 7.11-7.19 (m, 2H) , 7.31-7.34 (m, IH) , 3.50 , 7.79 (d, 2H) , 7.85 (d, 2H) , 13.08-13.14 (b, IH) . MS (m/z) / M+l = 408/409 HPLC (uv purity, = 214 nm) = 98.3% Example 182: Rl= 3-carboxylic acid cyclohexyl, R2= methyl, R3= 4- (methylsulfonyl) -phenyl 3- [5- (4-methanesulfonyl-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanecarboxylic acid 182 was prepared by the procedure described in example 14 with the appropriate reagents and using 1.0 eq of triethylamine. The mixture was filtered and the filtrate was evaporated to dryness. The residue was purified by silica gel chromatography eluting with CHCl 3 /MeOH (93/7) to afford 15 mg of the desired product. Yield= 1.52% X H-NMR (400MHz, DMSO) δ P m: 1.02-1.24 (m, 4H) , 1.58-1.70 (m, 3H) , 1.80-1.86 (m, IH) , 2.12-2.19 (m, IH) , 2.44-2.52 (m, IH) , 3.06 (s, 3H) , 3.36 (s, 3H) , 7.70 (d, 2H) , 7.82 (d, 2H) , 11.82-11.90 (b, IH) . MS (m/z) / M+l = 395/396 HPLC (uv purity, χ= 214 nm) : 98.76% Example 183: Rl= piperidin-1-yl, R2= methyl, R3= 4- (methylsulfonyl) -phenyl [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene] -piperidin-1-yl amine To a suspension of 1,3,4-thiadiazolium perchlorate (3b) (1.26 mmol, 0.5 g) in ethanol (6 ml) were added 1- aminopiperidine (2.5 mmol, 0.3 ml) then triethylamine (2.5 mmol, 0.4 ml) and the mixture was maintained at 70°C for 3 hours . The mixture was concentrated under reduced pressure . The residue was taken into dichloromethane, washed twice with water, concentrated under reduced pressure and purified by chromatography on silica gel (99:1 DCM/MeOH) to give 0.2 g of the title compound. Yield = 45%. X H-NMR (400MHz, CDC1 3 ) δ PP™: 1.46 (s, 2H) , 1.68-1.71 (m, 4H) , 2.77 (s, 4H) , 3.07 (s, 3H) , 3.65 (a, 3H) , 7.81-7.83 (dd, 2H) , 7.95-7.97 (dd, 2H) . MS (m/z) / M+l= 353.46. HPLC (uv purity, = 214 nm) = 97.4% Example 184: Rl= tetrahydro-pyran-4-yl, R2= methyl, R3= 4- (methy1sulfonyl) -phenyl [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] hiadiazol- 2-ylidene] - (tetrahydro-pyran-4-yl) -amine To a suspension of 1,3,4-thiadiazolium perchlorate (3b) (0.7 mmol, 0.3 g) in ethanol (4 ml) were added 4- aminotetrahydropyran (1.4 mmol, 0.3 g) and triethylamine (3 mmol, 0.4 ml). The mixture was maintained for 3 hours at 70°C, concentrated under reduced presaure. The residue was taken into dichloromethane, washed once with water, concentrated under reduced pressure and , . purified by chromatography on silica gel (99:1 DCM/MeOH) and washed with ethyl acetate and heptane to give 23 mg of the expected compound. Yield= 30%. X H-NMR (400MHz, CDCl 3 ) δ PPm: 1.68-1.85 (m, 4H) , 2.88-2.95 (m, IH) , 3.07 (s, 3H) , 3.47-3.57 (m, 2H) , 3.65 (s, 3H) , 4.01-4.06 (m, 2H) , 7.8-1 (d, 2H) , 7.97 (d, 2H) . MS (m/z) / M+l= 354.03 HPLC (uv purity, χ= 214 nm) = 100%. Example 185: Rl= 3 -benzoic acid, R2= methyl, R3= 4- acetylamino-phenyl 3- [5- (4-Acetylamino-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid A suspension of 1,3,4-thiadiazolium triflate (3d) (0.7 mmol, 0.3 g) , triethylamine (2.1 mmol, 0.3 ml) and 3- (SO acetamidobenzoic acid (0.6 mmol, 0.077 g) in ethanol (20 ml) was refluxed overnight . The mixture was concentrated under reduced pressure, purified by chromatography on silica gel (95:5 DCM /MeOH) and washed with MeOH to give 0.01 g of a white solid. Yield= 5% X H-NMR (400MHz, DMSO) δ PPm 2.06 (s, 3H) , 2.71 (s, 3H) , 7.26 (d, IH) , 7.47 (t, IH) , 7.60-7.70 (m, 6H) , 10.18 (s, IH) . MS (m/z) / M+l=368.95 HPLC (uv purity, = 214 nm) = 98% Example 186: Rl= trans-4-hydroxy-cyclohexyl, R2= methyl, R3= 4-acetylamino-phenyl N-{4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -phenyl} -acetamide A mixture of trans-4-aminocyclohexanol (0.28 mmol, 0.04 g) , triethylamine (0.39 mmol, 0.06 ml) and 3-methyl-2- methylthio [1, 3,4] thiadiazolium triflate (3d) (0.14 mmol, 0.05 g) were refluxed in ethanol (1ml) overnight. The mixture was concentrated under reduced pressure . . The residue was taken into dichloromethane, washed once with water, concentrated under reduced pressure and purified by chromatography on silica gel (95:5 DCM /MeOH) to give 0.014g of a white solid. Yield= 30% X H-NMR (400MHz, DMSO) ppm: 1.23-1.38 (m, 4H) , 1.76-1.86 (m, 4H ), 2.06 (s, 3H) , 2.45-2.60 (m, IH) , 4.52 (d, IH) , 3.38-3.44 (m, IH) , 3.47 (m, 3H) , 7.58 (d, 2H) , 7.68 (d, 2H) , 10.15 (s, IH) . MS (m/z) / M+l = 346.87 HPLC (uv purity, χ= 214 nm) = 98.5% Example 187: Rl= (1R*,3S*) -3-hydroxy-cyclohexyl, R2= methyl, R3= 4-acetylamino-phenyl N-{4- [5- ( (1R*,3S*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2 -yl] -phenyl}-acetamide 187 was prepared by the procedure described in example 186 (protocol A) . 187 was purified by chromatography on silica gel with AcOE : Cyclohexane (80:20) and washed with MeOH to give 0.15g of the expected compound. Yield= 20% X H-NMR (400MHz, DMSO) δ PP™: 1.10-1.30 (m, 4H) , 1.55-2.00 (m, 4H) , 2.10 (s, 3H) , 2.60 (m, IH) , 3.50 (m, IH) , 3.50 (s, 3H) , 4.6 (d, IH) , 7.60 (dd, 2H) , 7.60 (dd, 2H) , 10.15 (S,1H) . M+l = 347.1 Example 188: Rl= (1R*,3R*) -3 -hydroxy-cyclohexyl, R2= methyl, R3= 4-acetylamino-phenyl N-{4- [5- ( (1R*,3R*) -3-hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -phenyl} -acetamide To a suspension of 187 (0.4 mmol, 0.15 g) in DCM (2 ml) containing 4A molecular sieves (0.216 g) , N-methyl morpholine oxide (0.65 mmol, 0.76 g) under nitrogen atmosphere was added tetrapropylammonium perruthenate (10% mol equiv. , 15 mg) . The resulting mixture L waa stirred overnight, filtered, washed with methanol and concentrated under reduced pressure. The residue was purified by chromatography on silica gel with DCM:MeOH (95:5) to give 0.1 g of a ketone intermediate: N- {4- [4-Methyl-5- (3-oxo- cyclohexylimino) -4, 5-dihydro- [1, 3,4] thiadiazol-2-yl] - phenyl } -acetamide Yield= 71% X H-NMR (400MHz, DMSO) δ ppm: 1.25 (m, IH) , 1.60-1.75 (m, 2H) , 1.85-2 (m, 2H) , 2.05 (s, 3H) , 2.3 (m, 3H) , 3.15 (m, IH) , 3.5 (s, 3H) , 7.55 (dd, 2H) , 7.70 (dd, 2H) , 10.15 (s,lH). To a aolution of this ketone intermediate (0.15 mmol, 0.05 g) in THF (2 ml) at -70°C under nitrogen atmosphere was added a IM solution of L-Selectride in THF (0.2 mmol, 0.2 mL) . The resulting mixture was allowed . to warm up to room temperature over 1 hour, diluted with dichloromethane, washed with water and concentrated under reduced pressure . The residue was purified by chromatography on silica gel with AcOEt : Cyclohexane (80:20) to give 30 mg of the expected product . Yield= 60% X H-NMR (400MHz, CDCl 3 ) δ PPm: 1.25-1.30 (m, " 3H) , 1.72-1.78 (m, 5H),2.20 (s, 3H) , 3.11-3.14 (m, IH) , 3.58 (s, 3H) , 4.13 (m, IH) , 7.20 (s, IH) , 7.52-7.60 (m, 4H) . MS (m/z) / M+l= 347.21 HPLC (uv purity, λ= 214 nm) = 98% Example 189 : Rl= (1R*,3R*) -3 -hydroxy-cyclohexyl, R2= methyl, R3= 4-acetylamino-pyridin-3-yl W-{5- [5- ( (1R*,3R*) -3-hydroxy-cyclohexylimino) -4-methyl-4,5- dihydro- [1,3,4] thiadiazol-2-yl] -pyridin-2-yl}-acetamide The compound 189 was prepared by the procedure described in example 14 (protocol A) . To a suspension of 1,3,4-thiadiazolium perchlorate (3e) (0.5 mmol, 2 g) in ethanol (20 ml) were added triethylamine (1.5 mmol, 2 ml) followed by 3-aminocyclohexanol (0.8 mmol, 0.9 ml) and the mixture was maintained at 70°C overnight, concentrated under reduced pressure. The residue was ■ taken into dichloromethane, washed twice with water, concentrated under reduced pressure and purified by chromatography on silica gel (20:80 cyclohexane /EtOAc) to give 0.03g of a white solid. Yield= 17% X H-NMR (400MHz, DMSO) δ PP™: 1.37-1.65 (m, 8H) , 2.11 (s, 3H) , 3.03-308 (m, IH) , 3.50 (s, 3H) , 3.91-3.92 (m, IH) , 4.41 (d, IH) , 8.01-8.03 (dd, IH) , 8.17 (d, IH) , 8.55 (d, IH) , 10.75 (s, IH) . MS (m/z) / M+l= 348.3 HPLC (uv purity, λ= 214 nm) = 99.2% Example 190: Rl= 3-cyano-phenyl, R2= methyl, R3= 4-chloro- phenyl 3 - [5- (4-Chloro-phenyl) -3 -methyl-3H- [1, 3 , 4] thiadiazol-2 - ylideneamino] -benzonitrile l ≤Z To a suspension of 16.11 (4.14 mmol, 1.43 g) in pyridin (20 mL) was added benzoyl chloride (8.28 mmol, 964 μL) . The mixture was heated at reflux for 2 days. The solvent was concentrated under reduced pressure, the reaction mixture was retaken in an aqueous solution of NaHCθ3 and the crude product was extracted with dichloromethane. The compound was purified by chromatography on silica gel (eluted with cyclohexane/ethyl acetate: 80/20 to 70/30) to give 1.25 g of the expected compound (92%). X H-NMR (400 MHz, DMSO)δ ppm: 3.8 (s, 3H) , 7.40 (d, IH) , 7.48 (s, IH) , 7.52-7.60 (m, 4H) , 7.73 (d, 2H) . MS (m/z) / M+l= 327/329 HPLC (uv purity, χ= 245nm) = 99.4% Example 190.1: Rl= 3- (lH-Tetrazol-5-yl) -phenyl, R2= methyl, R3= 4-chloro-phenyl [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylidene] - [3- (lH-tetrazol-5-yl) -phenyl] -amine A mixture of 190 (1.22 mmol, 0.4 g) , sodium azide (1.59 mmol, 0.1 g) and triethylamine hydrochloride (1.59 mmol, 0.22 g) in toluene (7 mL) was heated at 90 °C .with stirring under nitrogen atmosphere. After cooling, the reaction mixture was poured in water and extracted with dichloromethane. To the aqueous layer, aqueous HCl 0. IN. was added until the pH is acidic (CAUTION! This has ' to be done under a well ventilated hood) . The precipitate was filtered, washed with ether and the resulting compound was cristallized in dichloromethane containing few drops of methanol to give 0.1 g of the desired compound Yield: 24% X H-NMR (400 MHz, DMSO) δ PPtn: 3.8 (s, 3H) , 7.28 (d, IH) , 7.55 (d, 2H) , 7.60 (t, IH) , 7.70-7.77 (m, 4H) MS (m/z) / M+l = 370/372 HPLC (uv purity, χ= 245 nm) = 99.7% Example 190.2: Rl= 3- (N-Hydroxycarbamimidoyl) -phenyl, R2= methyl, R3= 4-chloro-phenyl 3- [5- (4-Chloro-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2 - ylideneamino] -N-hydroxy-benzamidine To a mixture of 190 (1.53 mmol, 0.5 g) and hydroxylamine hydrochloride (2.29 mmol, 0.156 g) in ethanol (13 mL) was added sodium hydroxyde (2.29 mmol, 0.09 g) dissolved in the minimum of water. The reaction mixture was heated at reflux for 24h with stirring. After cooling, the precipitate is filtered, washed with ethanol and dried under vacuum at 45°C to give 0.54 g of the desired compound Yield: 98% X H-NMR (400 MHz, DMSO)δ ppm: 3.8 (a, 3H) , 5.76 (bs, 2H) , 7.05 (dd, IH) , 7.34-7.4 (m, 3H) , 7.54 (d, 2H) , 7.70 (d, 2H)-, 9.6 (s, IH) . MS (m/z) / M+l= 360/362 HPLC (uv purity, λ= 245 nm) = 97.3% Example 190.3: Rl= 3- (5-hydroxy- [1,2,4] oxadiazol-3-yl) - phenyl, R2= methyl, R3= 4-chloro-phenyl 3-{3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -phenyl}- [1,2,4] oxadiazol-5-ol A mixture of 190.2 (2.78 mmol, 0.1 g) t and 1,1'- carbonyldiimidazole (5.56 mmol, 0.9 g) in anhydrous THF (2 mL) was heated at reflux for 5h. After cooling, the reaction mixture was concentrated and poured in water. Dichloromethane was added and the precipitate was filtered and washed with methanol. The resulting mixture was purified by chromatography on silica gel (eluent dichloromethane/methanol: 98/2 + 1% acetic acid) to give 0.03 g of the desired product. Yield: 28% X H-NMR (400 MHz, DMSO)δ ppm: 3.8 (s, 3H) , 7.20 (dt, IH) , 7.50-7.55(m, 5H) , 7.70 (d, 2H) . MS (m/z) / M+l = 386/388 HPLC (uv purity, λ= 245 nm) = 98.2% EXAMPLE I: PROTOCOL C Example 191: Rl= cyclohexyl, R2= methyl, R3= 3-methyl-4- bro o-phenyl [5- (4-Bromo-3-methyl-phenyl) -3 -methyl-3JT- [1,3,4] thiadiazol- 2-ylidene] -cyclohexyl-amine 191 was prepared by the procedure described in example 118 (Protocol C) using appropriate intermediates and reagents. Yield= 50.4 % X H-NMR (400MHz, CDCl 3 ) δ PPm: 1.21-1.51 (m, 5H) , 1.64-1.70 (m, IH) , 1.78-1.89 (m, 4H) , 2.38 (s, 3H) , 2.56-2.64 (m, IH) , 3.55 (s, 3H) , 7.28 (d, IH) , 7.47 (s, IH) , 7.54 (d, IH) . MS (m/z) / M+l= 366/368 Example 191.1: Rl= cyclohexyl, R2= methyl, R3= 3-methyl-4- cyano-phenyl 4- (5-Cyclohexylimino-4-methy1-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -2 -methyl-benzonitrile To a solution of 191 (7.370 mmol, 2.7 g) in N-methyl-2- pyrrolidone (17ml), copper cyanide (13.267 mmol, 1.19 g) was added and the mixture was heated at reflux for 3h. The mixture was cooled at room temperature, basified with a solution of aqueous ammonia (2N) and stirred lOh at room temperature. The suspension was then filtered through Celite and the aqueous layer was extracted with ethyl acetate, washed with water and brine, dried (MgS0 4 ) , filtered and then concentrated under reduced pressure. The residue was purified by chromatography on silica gel, eluting with a gradient of dichloromethane containing from 0 to 1% of methanol . Yield= 54.8 X H-NMR (400MHz, CDCI3) δ ppm: 1.22-1.59 (m, 5H) , 1.64-1.67 (m, IH) , 1.77-1.87 ( , 4H) , 2.57-2.67 (m, 4H) , 3.60 (s, 3H) , 7.52 (d, IH) , 7.56 (s, IH) , 7.63 (d, IH) . Example 191.2: Rl= cyclohexyl, R2= methyl, R3= 3-methyl-4- benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -2-methyl-benzamide To a solution of 191.1 (0.320 mmol, 0.1 g) in ethanol (17 ml), an aqueous solution of sodium carbonate 3N (3.424 mmol, 1.14 ml) then a solution of hydrogen peroxide (5.60 ml) were added. The suspension was stirred for 2 days at room temperature, then heated at 40°C for 8h. The mixture was poured into a solution of Na 2 S2θ5.and evaporated to dryness then the crude material was diluted with water and extracted with dicloromethane. The organic layer was washed with water and brine, dried over MgS0 4 , filtered and concentrated under reduced pressure. Yield: 70% X H-NMR (400MHz, CDCl 3 ) δ PPm: 1.22-1.51 (m, 5H) , 1.60-1.68 (m, IH) , 1.81-1.91 (m, 4H) , 2.52 (s, 3H) , 2.59-2.69 (m, IH) , 3.60 (m, 3H) , 5.64-5.83 (b, 2H) , 7.49 (s, 2H) , 7.48 (a, IH) . MS (m/z) / M+l= 331/332. HPLC (uv purity, χ= 214 nm) : 97.28% Example 92: Rl= cyclohexyl, R2= methyl, R3= 4-bromo-3- methoxy-phenyl [5- (4-Bromo-3-methoxy-phenyl) -3 -methy1-2, 3-dihydro- [1,3,4] thiadiazol-2-yl] -cyclohexyl-amine To a mixture of 3-hydroxybenzoic acid (14.480 mmol, 2 g) in acetic acid (14.5 ml) and sulfuric acid (1.5 ml) at 50°C, a solution of bromine (15.204 mmol, 0.780 ml) in acetic acid (7.2 ml) was added and stirred 30 min at 100 °C. The reaction was allowed to room temperature and diluted with water. The aqueous layer was extracted with ethylacetate, washed with water and brine, dried (MgS0 4 ) , filtered and concentrated under reduced presaure to give the 4-Bromo-2-hydroxy-benzoic acid (yield =100%) . To a solution of 4 -bromo-3-hydroxybenzoic acid (14.480 mmol, 2.600 g) in acetone (180 ml), potassium carbonate (62.988 mmol, 8.710 g) and dimethylsulfate (31.422 mmol, 2.970 ml) were added. The reaction was stirred at room temperature for 30 min and evaporated to dryness. The residue was then diluted with water and extracted with ethylacetate. The collected organic layer was washed with water and brine, / S7 dried (MgS0 4 ) , filtered and concentrated under reduced preasure. 4-Bromo-3-methoxy-benzoic acid methyl ester was isolated by chromatography on silica gel eluting with cyclohexane containing from 0 to 20% ethylacetate (yield= 47%) . To a solution of 4-Bromo-3-methoxy-benzoic acid methyl ester (6.875 mmol, 1.676 ml) in a mixture l/l of THF/ MeOH (15ml), lithium hydroxyde (7.553 mmol, 0.180 g) was added and the reaction was stirred at room temperature overnight before distillation of volatiles. The residue was diluted with water, acidified with a solution of HCl (IN) and stirred for Ih. The formed precipitate was filtered off, washed with water and petroleum ether to give 4-Bromo-3-τnethoxy-benzoic acid (Yield = 56%) . The title compound was prepared by procedure as described in example 117 (protocol C) starting from 4-Bromo-3-methoxy- benzoic acid. In this particular case, methyltrifluoromethanesulfonate (1.2eq) was added once and the basic aqueous layer was extracted with DCM. The crude was chromatographed on silica gel eluting with cyclohexane containing from 0 to 10% ethylacetate. The oil obtained was triturated in diethylether and the formed white solid was isolated by filtration. Yield = 26% (overall, the 2 steps) . X H-NMR (400MHz, CDC1 3 ) δ Pm: 1.20-1.46 (m, 5H) , 1.60-1.68 (m, IH) , 1.77-1.88 (m, 4H) , 2.58-2.68 (m, IH) , 3.59 (a, 3H) , 3.96 (S, 3H) , 7.02 (d, IH) , 7.22 (s, IH) , 7.53 (d, IH) Example 192.1: Rl= cyclohexyl, R2= methyl, R3= 3-methoxy-4- benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -2-methoxy-benzamide 192 was reacted with copper cyanide by the , procedure described in example 191-1 and the formed intermediate was transformed to 192.1 following the following protocol: To a heterogeneous solution of this material (0.9134 mmol, 0.300 g) in ethanol (50 ml), a solution of sodium carbonate (3N) (9.773 mmol, 3.258 ml) and hydrogen peroxide (13.3 ml) were added and the reaction was heated at 40°C for 1.5 days. The mixture was poured into a saturated solution of 2S2θ 5 and the solution was concentrated under reduced pressure.' The residue was diluted with water, extracted with dichloromethane and the organic layer was washed with water and brine, dried over MgS0 4 , filtered and then evaporated to dryness. The crude material was purified by chromatography on silica gel eluting with dichloromethane containing from 0 to 4% methanol. Yield: 25% X H-NMR (400MHz, CDCl 3 ) δ PPm: 1.20-1.50 (m, 5H) , 1.76-1.88 (m, 4H) , 2.59-2.69 (m, IH) , 3.60 (s, 3H) , 4.02(s, 3H) , 5.80- 5.90 (b, IH) , 7.25 (d, IH) , 7.34 (s, IH) , 7.62-7.67 (b, IH) , 8.23 (d, IH) . MS (m/z) / M+l= 347/348 HPLC (uv purity, λ= 214 n ) : 97.61% Example 192.2: Rl= cyclohexyl, R2= methyl, R3= 3-hydroxy-4- benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] hiadiazol- 2-yl) -2-hydroxy-benzamide To a mixture of 192.1 and n-tetrabutylammonium iodide (0.433 mmol, 0.160 g) in anhydrous dichloromethane (2 ml) under nitrogen atmosphere at -78°C, a solution of BC1 3 I in " dichloromethane . (0.433 mmol, 0433 ml) was added and the reaction mixture waa allowed to atir at -78°C for 10 min followed by 2h at 0°C and lh30 at room temperature. Then, a solution of BCI3 IN in dichloromethane (0.433 mmol, 0433 ml) was added. After an additionnal lh30 of stirring at room temperature, the reaction was quenched with water and basified with a saturated solution of sodium bicarbonate before extraction with dicloromethane. The organic layer was washed with brine, dried over MgS0 4 , filtered and evaporated to dryness. The residue was chromatographed on silica gel eluting with dichloromethane containing from 0 to 4% of methanol to give the desired product. Yield= 26% X H-NMR (400MHz, CDC1 3 ) δ ppm: 1.21-1.50 (m, 5H) , 1.63-1.70 (m, IH) , 1.80-1.90 (m, 4H) , 2.58-2.68 (m, IH) , 3.60 (a, 3H) , 5.70-6.20 (b, 2H) , 7.18 (a, IH) , 7.24 (d, IH) , 7.38 (d, IH) , 12.25 (s, IH) . MS (m/z) / M+l= 333/334 HPLC (uv purity, X= 214 nm) : 96.54% Example 93: Rl= cyclohexyl, R2= methyl, R3= 3-nitro-4- methoxycarbonyl-phenyl 4- (5-Cyclohexylimino-4-methy1-4, 5-dihydro- [1,3,4] thiadiazol- 2 -yl) -2-nitro-benzoic acid methyl ester 193 was prepared by the procedure described in example 121 (protocol C) using the appropriate intermediates and reagents. In this particular case, triethylamine was not used and the expected product was isolated by filtration after treatment with a saturated solution of NaHC0 3 . Yield= 77% X H-NMR (400MHz, CDCl 3 ) δ PPm: 1.20-1.48 (m, 5H) , 1.64-1.70 (m, IH) , 1.80-1.90 (m, 4H) , 5.58-5.66 (m, IH) , 3.63 (s, 3H) , 3.82 (s, 3H) , 7.80-7.84 (m, 2H) , 8.11 (s, IH) . Example 193.1: Rl= cyclohexyl, R2= methyl, R3= 3-amino-4- methoxycarbonyl-phenyl 2-Amino-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester To a solution of 193 (1.328 mmol, 0.500 g) in ethanol (20 ml), tin chloride dihydrate (6.641 mmol, 1.495 g) was added and the mixture was heated at reflux for 5h then allowed to stand at room temperature overnight . The mixture was evaporated to dryness and the crude material was basified with a saturated solution of sodium carbonate before extraction with dichloromethane. The organic layer was washed with brine, dried over ' MgS0 4 , filtered and concentrated under vaccum. The residue was chromagraphed on silica gel eluting with dicloromethane containing from 0 to 2% of methanol to afford the desired compound. Yield: 65% X H-NMR (400MHz, CDCl 3 ) δ ppm: 1.21-1.49 (m, 5H) , 1.60-1.69 (m, IH) , 1.80-1.90 (m, 4H) , 2.58-2.67 (m, 1H),3.60 (a, 3H) , 3.89(8, 3H) , 5.77-5.83 (b, 2H) , 7.88-7.92 (m, 2H) , 7.89 (d, IH) . MS (m/z) / M+l= 347/349 HPLC (uv purity, χ= 214 nm) : 98.31% Example 193.2: Rl= cyclohexyl, R2= methyl, R3= 3- acetylamino-4-methoxycarbonyl-phenyl 2-Acetylamino-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -benzoic acid methyl ester To a suspension of 193.1 (0.144 mmol, 0.05 g) in anhydrous toluene (2 ml) at 0°C, triethylamine (0.150 mmol, 0.015 ml) and acetic anhydride (0.160 mmol, 0.015 ml) were added. The reaction was allowed to stir at room temperature for 3 days and 5.4 more equivalents of acetic anhydride and triethylamine were added. After 2 days of stirring at room temperature the mixture was evaporated to dryness and the residue was chromatographed on silica gel eluting with dichloromethane containing from 0 to 1% of methanol. Yield = 89% X H-NMR (400MHz, CDC1 3 ) δ PPm: 1.21-1.49 (m, 5H) , 1.60-1.67 (m, IH) , 1.76-1.88 (m, 4H) , 2.28 (s, 3H) , 2.60-2.70 (m, IH) , 3.60 (S, 3H) , 3.93 (s, 3H) , 7.45 (d, IH) , 8.03 (d, IH) , 8.98 (s, IH) , 11.10 (s, IH) . MS (m/z) / M+l= 389/390 HPLC (uv purity, λ=214 nm) : 96.93% Example 193.3: Rl= cyclohexyl, R2= methyl, R3= 3-amino-4- benzamide 2-Amino-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -benzamide 193 was modified following the procedure described in example 137.3 to afford the amide derivative with an overall yield 84%. The reduction of the nitro group to give 193.3 was performed as described in example 193.1. In this particular case, the reactionnal mixture was basified with a saturated solution of sodium carbonate then distilled. The crude was diluted in water and extracted with dicloromethane. The aqueous phase, saturated with brine, was then extracted with ethylacetate and the organic layer was dried over MgS0 4 , filtered and evaporated to dryness to give a residue which was purified by two consecutive chromatographies on silica gel, eluting first with dichloromethane/methanol (93/7) and the second purification made eluting with a gradient of cyclohexane containing from 0 to 40% ethylacetate. Yield= 10% X H-NMR (400MHz, DMSO) δ PP™: 1.27-1.40 (m, 5H) , 1.56-1.62 (m, IH) , 1.70-1.80 (m, 4H) , 2.58-2.65 (m, IH) , 3.50 (a, 3H) , 6.73-6.78 (m, 3H) , 7.00 (a, IH) , 7.10-7.20 (b, IH) , 7.61 (d, IH) , 7.75-7.85 (b, IH) . MS (m/z) / M+l= 332/333 HPLC (uv purity, λ= 214 nm) : 95.83% Example 193.4: Rl= cyclohexyl, R2= methyl, R3= 4-oxo-3,4- dihydro-quinazoline-7-yl 7- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,,4] thiadiazol- 2-yl) -3H-quinazolin-4-one A mixture of 193.1 (1.443 mmol, 0.500 g) and formamide (4 ml) was stirred and heated at reflux for 2h before cooling at room temperature. The mixture was diluted with water and the precipitate was collected by filtration. The precipitate was washed with water and petroleum ether and purified by chromatography on silica gel, eluting with dichloromethane containing from 0 to 3% of methanol followed by an isocratic elution with dichloromethane/methanol (93/7) . Yield= 20% X H-NMR , (400MHz, DMSO) δ PPm: 1.20-1.40 (m, 5H) , 1.55-1.64 (m, IH) , 1.70-1.83 (rri, 4H) , 2.63-2.71 (m, IH) , 3.56 (s, 3H) , 7.73, (s, IH) , 7.00 (s, IH) , 7.80 (d, IH) , 8.12-8.19 (m, 3H) , 12.30-12.40 (b, IH) . MS (m/z) / M+l= 342/343 HPLC (uv purity, λ= 214 nm) : 95.19% Example 193.5: Rl= cyclohexyl, R2= methyl, R3= 4-amino- quinazoline-7-yl 7- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -quinazolin-4-ylamine A mixture of 193.4 (0.264 mmol, 0.090 g) , thionyl chloride (2 ml) and a catalytic amount of dimethylformamide was refluxed for 2h before distillation of ' solvents under reduced pressure. To the residue, a solution of NH 3 (0.5N) in dioxan (4 ml) was added and the mixture was heated in a sealed tube at 80°C for 4 days. The mixture was then evaporated to dryness and the crude was diluted in a solution of acetic acid (0.1 ml AcOH in 10 mml H 2 0) , and extracted with dichloromethane to remove the impurities. The aqueous phase waa then baaified ' with a aolution NaOH (0.1N) and then extracted with dichloromethane. The organic layer was washed with water, brine, dried over MgS0 4 , filtered and concentrated under reduced pressure to give the desired product . Yield= 7.5% X H-NMR (400MHz, CDC1 3 ) δ PPm: 1.29-1.50 (m, 5H) , 1.60-1.69 (m/ IH) , 1.79-1.90 Cm, 4H) , 2.65-2.72 (m, IH) , 3.65 (s, 3H) , 5.60-5.70 (b, 2H) , 7.75 (d, IH) , 7.90 (s, IH) , 7.98. (d, IH) , 8.67 (s, IH) . MS (m/z) / M+l= 341/343 HPLC (uv purity, λ= 214 nm) : 99.99% Example 193.6: Rl= cyclohexyl, R2= methyl, R3= 2,4-Dioxo- 1,2,3 , 4-tetrahydro-quinazoline-7-yl 7- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -lH-quinazoline-2,4-dione To a solution of 193.3 in THF (4ml), carbonyldiimidazole (0.464 mmol, 0".080 g) was added and the reaction was heated at reflux overnight. Carbonyldiimidazole (0.464 mmol, 0.080 g) was added and the mixture was kept at reflux for 24h. Then, the solvent was distilled and the residue was purified by chromatography on silica gel, eluting with a gradient of cyclohexane containing from 15 to 30%. The chromatographied product was solubized in ethylacetate and the organic layer was washed with water. The collected organic layer was washed with brine, dried over MgS0 4 , filtered and evaporated to dryness to give the title product . Yield= 13.3% X H-NMR (400MHz, DMSO) δ PPm: 1.28-1.39 (m, 5H) , 1.56-1.64 (m, IH) , 1.72-1.82 (m, 4H) , 2.62-2.67 (m, IH) , 3.54 (s, 3H) , 7.41-7.43 (m, 2H) , 7.94 (d, IH) , 11.17 (s, IH) , 11.36 (s, IH) . MS (m/z) / M+l = 358/359 HPLC (uv purity, λ= 214 nm) : 96.70% Example 194: Rl= cyclohexyl, R2= methyl, R3= 3-methoxy-4- sulfamoyl-phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2 -yl) -2 -methoxy-benzenesulfonamide The title compound was prepared by the procedure described in example 119 (protocol C) using the appropriate intermediates and reagents. The residue was purified by chromography on silica gel, eluting with dicloromethane containing from 0 to 2% of methanol. - - - - _. Yield= 59% X H-NMR (400MHz, CDCl 3 ) δ Ppm: 1.21-1.49 (m, 5H) , 1.63-1.69 (m, IH) , 1.77-1.87 (m, 4H) , 2.59-2.67 (m, 1H) ' ,3.60 (a, 3H) , 4.06 (s, 3H) , 5.02 (a, 2H) , 7.20 (d, IH) , 7.40 (s, IH) , 7.90 (d, IH) . MS (m/z) / M+l = 384/386 HPLC (uv purity, χ= 214 nm) : 99.99% Example 195: Rl= cyclohexyl, R2= methyl, R3= 4-methoxy-3- sulfamoyl-phenyl 5- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -2-methoxy-benzenesulfonamide The title compound was prepared by procedure as described in example 118 (protocol C) using the appropriate intermediates and reagents. In this particular case, the residue obtained after extraction and distillation was triturated with methanol and the precipitate was filtered off and purified by silica gel chromatography, eluting with a mixture of cyclohexane/ ethylacetate (1/1) . Yield= 9%. X H-NMR (400MHz, CDC1 3 ) δ PPm= 1.30-1.50 (m, 5H) , 1.62-1.70 (m, IH) , 1.80-1.90 (m, 4H) , 2.58-2.65 (m, IH) , 3.58 (s, 3H) , 4.02 (s, 3H) , 5.10 (s, 2H) , 7.09 (d, IH) , 7.80 (d, IH) , 8.12 (s, IH) . MS (m/z) / M+l = 383/384 HPLC (uv purity, χ- 214 nm) : 99.38% Example 196: Rl= 3-methoxycarbonyl-phenyl, R2= methyl, R3= 3 -cyano-phenyl 3- [5- (3 -Cyano-phenyl) -3 -methyl-3H- [1, 3,4] thiadiazol-2- ylideneamino] -benzoic acid methyl ester To a solution of 7j (1.25 mmol, 0.42 g) in anhydrous dioxane (14 mL) , was added methyltrifluoromethane sulfonate (1.5 mmol, 142 μl) . The resultant mixture was stirred for 24h at room temperature. To this solution • was added methyltrifluoromethane sulfonate (0.45 mmol, 43 μl) to ensure completion of the reaction. The solvent was removed by distillation under reduced pressure to give a crude material which was basified with an aqueous saturated solution of NaHC0 3 and extracted with dichloromethane. The organic layer was dried over Na 2 S0 , filtered and concentrated. The crude material was purified by 2 sucessive flash chromatographies (eluent: dichloromethane/methanol 95/5 and cyclohexane/ethyl acetate 90/10) to give the desired compound 0.23 g (yield 53%) . X H-NMR (400 MHz , DMSO) δ PPm: 3.75 (s, 3H) , 3.86 (s, 3H) , 7.34(d, IH) , 7.54 (t, IH) , 7.61 (s, IH) , 7.67-7.70 (m, 2H) , 7.94 (d, IH) , 8.02 (d, IH) , 8.12 (s, IH) . Oo≤ ' Example 196.1: Rl= 3-benzoic-acid, R2= methyl, R3= 3-cyano- phenyl 3- [5- (3-Cyano-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid A mixture of 196 (3 mg, 8.56 mmol) and potassium hydroxyde (IN in water, 12.8 mmol, 12.8mL) in tetrahydrofuran (90 ml) was stirred at room temperature overnight . The reaction mixture was heated at reflux for lh. After cooling, the reaction mixture is concentrated, water is added (2 mL) and a solution of HCl (IN in water, 12.8 mmol, 12.8 mL) is added. The precipitate is collected by filtration and washed succeaively with water and with ether before being dried under, vacuum at 45°C. The compound was purified by flash chromatography (eluent: dichloromethane/methanol 99/1 +1% acetic acid) to give 2.38 g of the title product Yield: 83% X H-NMR (400 MHz , DMSO) δ PP™ = 3.8 (s, 3H) , 7.31 (d, IH) , 7.51 (t, IH) , 7.61 (s, IH) , 7.65-7.69 (m, 2H) , 7.93 (d, IH) , 8.01 (d, IH) , 8.11 (s, IH) , 13.06 (s, IH) . MS (m/z) / M+l = 337/338 HPLC (uv purity, = 245 nm) : 99.6% Example 197: Rl= 3-methoxycarbonyl-phenyl, R2= methyl, R3= 2-pyridyl 3- [3-Methyl-5-pyridin-2-yl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid methyl ester To a solution of 7k (1.76 mmol, 0.55 g) in anhydrous dioxane (14 mL) and triethylamine (1.76 mmol, 264 μL) , methyltrif ' luoromethane sulfonate (1.76 mmol, 199 μL) was added. The resultant mixture was stirred for 24h. To this solution was added methyltrifluoromethane sulfonate (0.53 mmol, 60 μL) and triethylamine (0.53 mmol, 79.2 μL) to allow reaction to ' completion. The solvent was removed by distillation under reduced pressure to give a crude material which was basified with an aqueous saturated solution of NaHC0 3 and extracted with dichloromethane. The organic layer was dried over Na 2 S0 4 , filtered and concentrated. The crude material was purified by filtration on silica gel (eluent: dichloromethane) to give the desired compound. Yield: 28% X H-NMR (400 MHz, DMSO) δ PPm: 3.76 (a, 3H) , 3.86 (s, 3H) , 7.35 (dd, IH) , 7.48-7.54 (m, 2H) , 7.64-7.68 (m, 2H) , 7.96- 8.00 (m, 2H) , 8.58 (d, IH) . MS (m/z) / M+l: 327/329 Example 197.1: Rl =3-benzoic-acid, R2= methyl, R3= 2-pyridyl 3- [3-Methyl-5-pyridin-2-yl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid A mixture of 197 (16 g,0.49 mmol) and potaasium hydroxyde (IN in water, 0.58 mmol, 0.58 mL) in tetrahydrofuran (3ml) was stirred at room temperature for 48h. The reaction mixture was heated at reflux for 2h. After cooling, the reaction mixture is concentrated, water is added (5 mL) , the aqueous layer was extrated with dichloromethane and neutralized with a solution of HCl (0.1N in water). The precipitate is collected by filtration and washed successively with water and with ether before being dried under vacuum at 45°C to give 0.08 g of the title product. Yield: 54% X H-NMR (400 MHz , DMSO) δ Ppm: 3.8 (s, 3H) , 7.31 (d, IH) , 7.47-7.49(m, 2H) , 7.64-7.66 (m, 2H) , 7.96-7.98 (m, 2H) , 8.58 (d, IH) MS (m/z) / M+l= 313/314/315 HPLC (uv purity, χ= 245 nm) : 97.6% Example 198: Rl= 3-benzoic-acid, R2= methyl, R3= 4-Chloro-3- sulfamoyl-phenyl 3- [5- (4-Chloro-3 -sulfamoyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylideneamino] -benzoic acid 198 was prepared by the procedure described in example 196.1 using the appropriate intermediates and reagents. In this particular case, the ester intermediate was basified with triehylamine . The title product was isolated by chromatography on silica gel, eluting with ethylacetate / cyclohexane (15/85) . Yield=19% (2 steps) X H-NMR (400MHz, DMSO) δ ppm: 3.73 (s, 3H) , ' 3.85 (s, 3H) , 7.35 (d, IH) , 7.54 (t, IH) , 7.62 (s, IH) , 7.70 -7.80 (m, 4H) , 7.86 (d, IH) , 8.24 (s, IH) . MS (m/z) / M+l = 439/441 Then, A solution (IN) of potassium hydroxide (1.139mmol, 1.14ml) was added to a solution of the ester derivative (0.456mmol, 0.2g) in THF (5ml) and the mixture was stirred overnight. The reaction mixture was evaporated to dryness and the residue was diluted in ethanol and acidified with a solution (6.9N) of HCl in ethanol (0.165ml) . The mixture was stirred at RT for 5h and the solvent was distilled under reduced pressure. The crude material was chromatographed on silica gel, eluting with a gradient of dichloromethane containing from 5 to 25% methanol. The isolated product was solubilized in THF and filtered through a pad of ailica gel and the filtrate waa evaporated to dryness to afford the desired product. j Yield = 37%. X H-NMR (400MHz, CDC13) δ ppm: 3.74 (s, 3H) , 7.24 (d, IH) , 7.45 (t, IH) , 7.62 (s, IH) , 7.66 (d, IH) , 7.73-7.80 (m, 3H) , 7.84 (d, IH) , 8.23 (a, IH) . MS (m/z) / M+l= 425/427 HPLC (uv purity, λ= 214 nm) : 94.86% EXAMPLE I: PROTOCOL D Example 199: Rl= cyclohexyl, R2= methyl, R3= 4-cyano-phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol- 2-yl) -benzonitrile Compound 199 was prepared by the procedure described in exemple 115 (protocol D) . To a mixture of 4-cyanobenzoic acid (74.8 mmol, 11 g) , 2- methylthiosemicarbazide 5a (74.8 mmol, 13.42 g) in anhydrous dioxane (110 mL) at 70°C, POCl 3 (89.65 mmol, 76.76 ml) was added and the mixture was . warmed at 95°C for 4 hours. The solvent was removed by distillation under reduced pressure to give a crude material which was basified at pH 8-7 with a saturated solution of NaHC0 3 . The aqueous phase was extracted with dichoromethane . The organic layer was washed with water and saturated solution of NaCl, dried over magnesium sulfate, filtered and distilled to give a residue which was purified by silica gel chromatography (eluted with a gradient of cyclohexane/ethyl acetate finishing with the ratio 90/10) to afford 8.5 g of the title compound. Yield: 42% X H-NMR (400MHz, DMSO) δ Ppm: L15-1.40 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.83 (m, 4H) , 2.57-2.70 (m, IH) , 3.55 (s, 3H) , 7.82 (dd, 2H) , 7.93 (dd, 2H) . Example 199.1: Rl= cyclohexyl, R2= methyl, R3= 4-(lH- tetrazol-5-yl) -phenyl Cyclohexyl-{3-methyl-5- [4- (lH-tetrazol-5-yl) -phenyl] -3H- [1,3,4] thiadiazol-2-ylidene}-amine To a solution of 199 (1.67 mmol, 500 mg) in toluene (2 ml), sodium azide (2.18 mmol, 142 mg) , triethylamine hydrochloride (2.18 mmol; 300 mg) were added and the mixture was warmed at reflux during 24 hours. The reaction mixture was cooled at room temperature, acidified with a solution of HCl [0.1N], and then basified at pH=6-7 with a saturated solution of NaHC0 3 . The aqueous phase was extracted with ethyl acetate and the organic layer was washed with a saturated solution of NaCl, " dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was chromatographed on silica gel column using a gradient of dichloromethane containing from 0 to 20% methanol to afford the title compound. Yield: 61% X H-NMR (400MHz, DMSO) δ PPm: 1.20-1.42 (m, 5H) , 1.55-1.65 (m, IH) , 1.70-1.85 (m, 4H) , 2.60-2.72 (m, IH) , 3.55 (a, 3H) , 7.85 (dd, 2H) , 8.13 (dd, 2H) MS (m/z) / M+l= 341/342 HPLC (uv purity, X = 214 nm) = 99.9% Example 1100: Rl= cyclohexyl, R2= methyl, R3= 4-nitro-phenyl Cyclohexyl- [3-methyl-5- (4-nitro-phenyl) -3H- [1,3,4] thiadiazol-2-ylidene] -amine 1100 was prepared as described in example 115 (protocol D) using the appropriate reagents. The crude material was purified by silica gel chromatography eluting with a gradient of cyclohexane containing from 0 to 10% ethylacetate. Yield: 40% X H-NMR (400MHz , DMSO) δ ppm: 1 . 20 - 1 . 40 (m, 5H) , 1 . 57 - 1 . 64 (m, IH) , 1 . 72 - 1 . 83 (m, 4H) , 2 . 61-2 . 91 (m, IH) , 3 . 56 ( a , 3H) , 7 . 89 (d, 2H) , 8 . 29 (d, 2H) . MS (m/z) / M+l = 319/320 Example 1100.1: Rl= cyclohexyl, R2= methyl, l R3= 4-amino- phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol- 2-yl) -phenylamine Tin chloride dihydrate (93.278 mmol, 20.987 g) was added to a solution 1100 (18.656 mmol, 5.940 g) in ethanol at 70°C and the mixture was refluxed for lh30. The mixture was then filtered on Celite and the filtrate was evaporated to dryness. The crude material was basified with a saturated solution of sodium bicarbonate then extracted with ethyl acetate. The organic layer was washed with water and brine, dried over MgS0 4 , filtered and then evaporated to dryness. The residue was filtred through a pad of silica gel with a mixture of dichloromethane/methanol (95/5) . Yield= 62% I 0 X H-NMR (400MHz, CDCI3) δ Ppm: 1.19-1.37 (m, 5H) , 1.56-1.63 (m, IH) , 1.70-1.80 (b, 4H) , 2.56-2.74 (m, IH) , 3.44 (s, 3H) , 5.60 (s, 2H) , 6.58 (d, 2H) , 7.29 (d, 2H) . MS (m/z) / M+l= 289/290 HPLC (uv purity, = 214 nm) : 97.61% Example 1100.2: Rl= cyclohexyl, R2= methyl, R3= 4- (N-cyano- N* - (2-dimethylaminoethyl) carboximidamide) -phenyl [5- (4- (N-cyano-N 1 - (2-dimethylaminoethyl) -carboximidamide) - phenyl) -3 -methyl-3ff- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl- amine To a solution of diphenylcyanocarbonimidate (0.364 mmol, 0.087 mmol) in acetonitrile (1 ml) at 70°C, 1100.1 (0.347 mmol, 0.1 g) was added and the reaction mixture was heated at 80°C for 15h. leq. of carbonimidiate was added and the mixture was kept at 80 °C for an additional 5h before evaporation of volatiles. The residue was mixed with ethanol (2 ml) and N,N-dimethylethylene diamine (0.34 mmol, 0.038 mg) . The mixture was stirred at room temperature for 15h and heated at reflux for 5h. On cooling to room temperature, the precipitate formed was filtered off and purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 2 to 5% methanol. Yield= 32% X H-NMR (400MHz, CDCI3) δ P™: 1.16-1.41 ( , 5H) , 1.50-1.70 (m, IH) , 1.80-1.91 (m, 4H) , 2.35 (s, 6H) , 2.50-2.60 (m, 3H) , 3.31-3.38 (m, 2H) , 3.55 (s, 3H) , 6.00-6.10 (b, IH) , 7.30 (d, 2H) , 7.52 (d, 2H) . MS (m/z) / M+l = 427/428 HPLC (uv purity, λ= 214 nm) : 97.23% Example 1100.3: Rl= cyclohexyl, R2= methyl, R3= 4-acetamide- phenyl N- [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2 -yl) -phenyl] -acetamide To a solution of 1100.1 (0.347 mmol, 0.1 g) in presence of triethylamine (0.361 mmol, 0.051 ml) in anhydrous toluene (3 n\ ml) at 0°C, acetic anhydride (0.382 mmol, 0.036 ml) was added and the reaction mixture was stirred at room temperature for 2Oh and then concentrated to dryness. The residue was mixed with a saturated solution of sodium bicarbonate and then the aqueous mixture was extracted with dichloromethane. The organic layer was washed with water, brine, dried over MgS0 4 , filtered and evaporated to dryness. The residue was purified by silica gel chromatography eluting with a mixture of methanol/dichloromethane (2/98) . Yield=22%. X H-NMR (400MHz, CDCl 3 ) δ PPm: 1.22-1.45 (m, 5H) , 1.58-1.68 (m, IH) , 1.80-1.88 (m, 4H) , 2.21 (s,.3H), 2.58-2.64 (m, IH) , 3.60 (3H, s),7.20 (s, IH) , 7.52-7.62 (m, 4H) . MS (m/z) / M+l = 331:332 HPLC (uv purity, λ= 214 nm) : 95.24% Example 1100.4: Rl= cyclohexyl, R2= methyl, R3= 4-(bis- ethylesulfonyl-amino) -phenyl [5- (4- (bis-ethylsulfonylamino) -phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine To a solution of 1100.1 (0.347 mmol, ..0.1 g) in dichloromethane (5 ml) with triethylamine (0.520 mmol, 0.072 ml),, chlorosulfonyl chloride (0.590 mmol, 0.057 ml) was added at 0°C and the mixture was stirred at room temperature for 4h30 before evaporation to dryness under reduced pressure. The crude material was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 5% methanol. Yield= 76% X H-NMR (400MHz, CDCI3) δ PP™: 1.20-1.52 (m, 11H) , 1.61-1.68 (m, IH) , 1.80-1.89 (m, 4H) , 2.59.-2.68 (m, IH) , 3.58-3.64 (m, 7H),7.40 (d, 2H) , 7.70 (d, 2H) . MS (m/z) / M+l= 473/475 HPLC (uv purity, χ= 214 nm) : 98.68% Example 1100.5: Rl= cyclohexyl, R2= methyl, R3= 4-(l-(2- dimethylaminoethyl) amino-2-nitro-vinylamino) -phenyl n- [5- (4- (1- (2-dimethylaminoethyl) amino-2-nitro-vinylamino) - phenyl) -3 -methyl-3JT- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl- amine To a solution of 1, 1-bis (methylthio) -2-nitroethylene (1.041 mmol, 0.172 g) in acetonitrile (1 ml), at 75°C, 1100.1 (0.347 mmol, 0.1 g) was added and the reaction was heated at reflux for 7h. The reaction mixture was then evaporated to dryness and the crude material was purified by silica gel chromatography eluting with a gradient of dichloromethane containing from 0 to 5% of methanol to give the desired intermediate (0.09 g, yield: 64%). A mixture of ethylenediamine (0.133 mmol, 0.017 ml) and this intermediate (0.111 mmol, 0.045 g) in ethanol (2 ml) was heated at reflux for 3h. The mixture was concentrated under reduce pressure to give a residue which was purified by silica gel chromatography eluting with dichloromethane containing 2% methanol. Yield= 90% X H-NMR (400MHz, CDC1 3 ) δ ppm: 1.23-1.49 ( , 5H) , 1.65-1.70 (m, IH) , 1.78-1.88 (m, 4H) , 2.45 (s, 6H) , 2.57-2.71 (m, 3H) , 3.51-3.61 (m, 5H) , 6.66 (s, IH) , 7.09 (d, 2H) , ,7.60 (d, 2H) , 10.55-10.62 (b, IH) , 12.28-12.40 (b, IH) . MS (m/z) / M+l= 446/447 HPLC (uv purity, = 214 nm) : 99.34% Example 1100.6: Rl= cyclohexyl, R2= methyl, R3= 4- (1-amino- 2-nitro-vinylamino) -phenyl (E) -N 1 - [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2 -yl) -phenyl] -2-nitro-ethene-l, 1-diamine The title product was prepared by the procedure described in example 1100.5 using a solution of ammonia (2N) in methanol (80 eq) instead of ethylenediamine . The desired product was isolated by chromatography on silica gel, eluting with a gradient of dichloromethane containing from 2 to 4 % methanol. Yield= 83% 113 X H-NMR (400MHz, CDC1 3 ) δ ppm: 1.20-1.47 (m, 5H) , 1.62-1.67 (m, IH) , 1.76-1.87 (m, 4H) , 2.60-2.66 (m, IH) , 3.60 (m, 3H) , 6.70 (s, IH) , 7.24 (d, 2H) , 7.67 (d, 2H) . MS (m/z) / M+l = 375/376 HPLC (uv purity, λ= 214 nm) : 94.09% Example 1100.7: Rl= cyclohexyl, R2= methyl, R3= 4- CW-cyano- N' -methyl-carboximidamide) -phenyl [5- (JNT-cyano-W -methyl-4-carboximidamide-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine To a solution of diphenylcyanocarbonimidate (0.364 mmol, 0.087 g) in acetonitrile (1 ml) at 70°C, 1100-1 (0.347 mmol, 0.1 g) was added and the mixture was heated at 80°C for 15h. One equivalent of diphenylcyanocarbonimidate was added and the mixture was stirred for 5h. The mixture was concentrated under reduced pressure to give the intermediate which was used without further purification. The intermediate (0.416 mmol, 0.300 g) in a solution (2N) of methylamine in MeoH (32.890 mmol, 16.64 ml) was refluxed for 8h then allowed to stand at room temperature for 2 days. The mixture was evaporated to dryness and the residue was «- purified by chromatography on silica gel, eluting with a gradient of dichloromethane containing from 0 to 4% of methanol to give the desired product. Yield: 29% X H-NMR (400MHz, CDCI3) δ PPm: 1.20-1.45 (m, 5H) , 1.62-1.67 (m, IH) , 1.76-1.87 (m, 4H) , 2.57-2.67 (m, IH) , 2.90 (d, 3H) , 3.60 (m, 3H) , 4.90-5.01 (b, IH) , 7.17-7.28 (m, 3H) , 7.69 (d, 2H) . MS (m/z) / M+l= 370/371 HPLC (uv purity, χ= 214 n ) : 99.99% Example 100.8: Rl= cyclohexyl, R2= methyl, R3= 4- (N-cyano- N" -amino-carboximidamide) -phenyl [5- (4- (N-cyano-N" -amino- carboximidamide) -phenyl) -3 -methyl- 3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine The title product was prepared by the procedure described in example 1100.7 using the same intermediate (0.416 mmol, 0.300 g) and a solution (2N) of ammonia in methanol (32.89 mmol, 16.64 ml). The desired product was purified by chromatography on silica gel eluting with a gradient of dichloromethane containing from 0 to 7% methanol . Yield= 67% X H-NMR (400MHz, CDC1 3 ) δ PP™: 1.20-1.46 (m, 5H) , 1.60-1.66 (m, IH) , 1.78-1.88 (m, 4H) , 2.55-2.65 (m, IH) , 3.58 (m, 3H) , 6.10 (a, 2H) , 7.42 (d, 2H) , 7.55 (d, 2H) , 8.71 (a, IH) . MS (m/z) / M+l = 356/357 HPLC (uv purity, X= 214 nm) : 97.39% Example 1100.9: Rl= cyclohexyl, R2= methyl, R3= 4- ethylsulfonylamino-phenyl Ethanesulfonic acid [4- (5-cyclohexylimino-4-methyl-4, 5- dihydro- [1,3,4] thiadiazol- -yl) -phenyl] -amide Ethylsulfonyl chloride (0.416 mmol, 0.040 ml) was added to a solution of 1100.1 (0.347 mmol, 0.10 g) in dichloromethane at 0°C. The mixture was stirred for 12 h at room temperature then basified with a saturated solution of sodium bicarbonate. The organic layer was collected and concentrated under reduce pressure . The crude material • was reacted with 1, 1-bis (methylthio) -2 -nitroethlene (2.690 mmol, 0.445 g ,10 eq) at reflux in acetonitrile (5 ml) for 24 h. The solvent was then distillated under reduced pressure and the residue was purified by silica gel chromatography eluting with dichloromethane containing a gradient from 0 to 10% methanol. Yield= 15% X H-NMR (400MHz, CDC1 3 ) δ PP™: 1.24-1.44 (m, 8H) , 1.62-1.68 (m, IH) , 1.78-1.87 (m, 4H) , 2.59-2.65 (m, IH) , 3.14-3.19 (q ~ , 2H) , 3.60 (s, 3H) , 6.44 (s, 2H) , 7.23 (dd, 2H) , 7.61 (dd, 2H) . MS (m/z) / M+l= 381/383 HPLC (uv purity, λ= 214 nm) : 99.22% H Example 1100.10: Rl= cyclohexyl, R2= methyl, R3= 4-Ureido- phenyl [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -phenyl] -urea To a solution of 1100.1 (0.348 mmol, 0.100 g) in THF (1 ml), trimethylsilyl isocyanate (0.416 mmol, 0.488 ml) was added and the mixture was stirred at room temperature for 10 h and water was added. The organic layer was extracted with ethylacetate, washed with water, brine, dried over MgS0 4 , filtered and then evaporated to dryness. The crude product was purified by chromatography on silica gel, eluting with a gradient of dichloromethane containing from 0 to 4% of methanol . Yield= 13% X H-NMR (400MHz, DMSO) δ PPm: 1.24-1.39 (m, 5H) , 1.53-1.57 (m, IH) , 1.69-1.80 (m, 4H) , 2.57-2.65 (m, IH) , 3.47 (s, 3H) , 5.92 (s, 2H) , 7.50 (s, 4H) , 8.79 (s, IH) . MS (m/z) / M+l= 332/333 HPLC (uv purity, λ= 214 nm) : 92.50% Example 1100.11: Rl= cyclohexyl, R2= methyl, R3= 4- [3- (2- dimethylamino-ethyl) -ureido] -phenyl 1- [4- (Cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -phenyl] -3- (2-dimethylamino-ethyl) -urea To a solution of 1100.1 (0.347 mmol, 0.100 g) with triethylamine (1.041 mmol, 0.145 ml) in dichloromethane anhydrous (5 ml) , was added a solution of phosgene (20% in toluene) (1.024 mmol, 0.487 ml) at 0°C. The mixture was stirred at 0°C for 10 min then allowed to raise to room temperature for lh and N,N-dimethyl-ethylene diamine (0.694 mmol, 0.076 ml) was added. After 20 h of stirring at room temperature, the mixture was basified with a saturated solution of sodium bicarbonate then extracted with dichloromethane. The organic phase was washed with water, brine , dried over MgS0 and evaporated under reduced pressure. The residue was chromatographed on silica gel n t≤> eluting with a mixture dichloromethane/methanol (95/5) to afford the tittle product. Yield* 11% X H-NMR (400MHz, CDC1 3 ) δ PPm: 1.20-1.50 (m, 5H) , 1.70-1.75 (m, IH) , 1.78-1.90 ( , 4H) , 2.33 (s, 6H) , , 2.58-2.68 (m, 3H) , 3.30-3.40 (b, 2H) , 3.60 (s, 3H) , 5.37-5.47 (b, IH) , 7.40 (d, 2H) , 7.55 (d, 2H) . MS (m/z) / M+l = 403/404 HPLC (uv purity, λ= 214 nm) : 99.99% Example 1101: Rl= cyclohexyl, R2= methyl, R3= 3-chloro-4- sulfamoyl-phenyl 2-Chloro-4- (5-cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide The title compound was prepared by the procedure described in example 115 (protocol D) using- the appropriate intermediates and reagents. The desired product was isolated by chromatography on silica gel, eluting with a gradient of cyclohexane containing from 0 to 30% ethylacetate. Yield: 23% X H-NMR (400MHz, CDCl 3 ) δ PPm: 1.21-1.49 (m, 5H) , 1.60-1.69 (m, IH) , 1.79-1.87 (m, 4H) , 2.59-2.69 (m, IH) , 3.60 (m, 3H) , 5.10 (s, 2H) , 7.58 (d, IH) , 7.80 (s, IH) , 8.10 (d, IH) . MS (m/z) / M+l = 388/389 HPLC (uv purity, λ= 214 nm) : 98.32% Example 1102: Rl=cyclohexyl, R2= methyl, R3= 3-chloro-4- methoxycarbonyl-phenyl 2-Chloro-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester 1102 was prepared by procedure as described in example 115 (protocol D) using the appropriate intermediates and reagents. The desired product was isolated by chromatography on silica gel eluting with a gradient of cyclohexane containing from 0 to 7% ethylacetate. (yield : 12%) X H-NMR (400MHz, CDCl 3 ) δ PP™: 1.21-1.48 (m f< _ 5H) , 1.60-1.67 (m, IH) , 1.78-1.87 (m, 4H) , 2.58-2.66 (m, IH) , 3.60 (s, 3H) , 4.93 (s, 3H) , 7.55 (d, IH) , 7.71 (s, IH) , 7.86 (d, IH) . Example 1102.1: Rl= cyclohexyl, R2= methyl, R3= 3-chloro-4- benzamide 2-Chloro-4- (5-cyclohexylimino-4-methy1-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide To a solution of 1102 (0.391 mmol, 0.147 g) in a mixture of THF/ MeOH (2 ml) (l/l), Lithium hydroxyde (0.430 mmol, 0.010 g) was added and the raction mixture was allowed to stir for 15h at room temperature. Lithium hydroxyde (0.430 mmol, 0.010 g) was added and the reaction was stirred for 24 h before evaporation to dryness. The crude material was acidified with a solution of HCl (IN) , stirred at room temperature for 3h and the mixture was then concentrated to dryness . Toluene (5 ml) was added to the residue (0.273 mmol, 0.120 g) followed by an addition of thionyl chloride (0.820 mmol, 0.598 ml) and the mixture was heated at reflux overnight before distillation of volatiles under reduced ^ pressure . The residue was poured into THF (5 ml) and cooled to 0°C then a solution of concentrated ammonia (6.833 mmol, 0.448 ml) was added. The reaction was allowed to stir at room temprature for 3 h and then the solvent was distilled. The residue was purified by chromatography on silica gel, eluting with dicloromethane containing from 0 to 1% methanol . Yield: 63% (overall) X H-NMR (400MHz, CDCl 3 ) δ PP™= 1.20-1.48 (m, 5H) , 1.62-1.69 (m, IH) , 1.79-1.88 (b, 4H) , 2.58-2.67 (m, IH) , 3.60 (m, 3H) , 5.86-5.93 (b, IH) , 6.38-6.48 (b, IH) , 7.57 (d, IH) , 7.70 (a, IH) , 7.87 (d, IH) . MS (m/z) / M+l= 351/353 , HPLC (uv purity, λ= 214 nm) : 96.60% Example 1103: Rl= cyclohexyl, R2= methyl, R3= 4-chloro-3- benzamide 2 -Chloro-5- (5-cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2 -yl) -benzamide The title compound was prepared by the procedure described in example 1102.1 using the appropriate intermediates and reagents (protocol D) . Yield: 47% X H-NMR (400MHz, CDCl 3 ) δ PP™: 1.20-1.42 (m, 5H) , 1.60-1.69 (m, IH) , 1.77-1.89 (b, 4H) , 2.55-2.65 (m, IH) , 3.60 (m, 3H) , 5.89-6.00 (b, IH) , 6.30-6.40 (b, IH) , 7.46 (d, IH) , 7.68 (d, IH) , 8.00 (S, IH) . MS (m/z) / M+l = 351/353 HPLC (uv purity, χ= 214 nm) : 98.70% PROTOCOL E: Intermediate 8 Rl= cyclohexyl, R2= methyl, R3= 4-methoxycarbonyl-phenyl 1- (4-methoxycarbonyl-benzoyl) -2 -methyl-4-cyclohexyl- thiosemicarbazide To a stirred solution of 5a (2.517 mmol, 0.456 g) in pyridine (6ml) , methyl-4-chloro carbonyl benzoate (2.517mmol, 0.500g) was added. The mixture was stirred 24h at RT, and then the pyridine was distilled under reduced pressure. The residue was poured into water and extracted with dichloromethane. The organic layer was washed with water, brine, dried over MgS04 and concentrated to dryness to afford 1.10g of product. 1H-NMR (400MHz, DMSO) δ PPm: 1.15-1.25 (m, 5H) , 1.51-1.61 (m, IH) , 1.61-1.71 (m, 2H) , 1.71-1.87 (m, 2H) , 3.28 (s, 3H) , 3.9 (s, 3H) , 4.10-4.21 (m, IH) , 8.00-8.10 (m, 4H) , 8.59 (d, IH) , 10.79 (S, IH) . EXAMPLE I : PROTOCOL E Example 1104: Rl= cyclohexyl, R2= methyl, R3= 4- methoxycarbonyl-phenyl 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [l,3,4]oxadiazol- 2-yl) -benzoic acid methyl ester A stirred mixture of the previous intermediate 8 (2.517 mmol, 1.10 g) and methanol (50 ml) was warmed until a homogeneous solution was obtained then mercury oxide (10.068 mmol, 2.18 g)' was added. After 18h at reflux, 3 more equivalents of HgO were added and the reaction was kept at reflux for an additionnal 6h then allowed to cool down to RT. The reaction was filtered through a pad of Celite and the filtrate was evaporated under reduced pressure . The crude material was purified by chromatography on silica gel eluting with cyclohexane containing from 10 to 20% ethylacetate. Yield= 44% X H-NMR (400MHz, DMSO) δ ppm: 1.1-1.4 (m, 5H) , 1.53-1.61 (m, IH) , 1.69-1.80 (m, IH) , 3.30 (s, 3H) , 3.40-3.48 (m, IH) , 3.88 (s, 3H) , 3.85 (d, 2H) , 7.96 (d, 2H) , 8.08 (d, 2H) . MS (m/z) / M+l =316/318 Example 104.1: Rl= cyclohexyl, R2= methyl, R3= 4-benzamide 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] oxadiazol- 2-yl) -benzamide The title compound was prepared by procedure described in example 137.3. The desired product was isolated by chromatography on silica gel eluting with dichloromethane containing from 1 to 2 % methanol . Yield= 26 % (overall) X H-NMR (400MHz, DMSO) δ ppm: 1.17-1.40 (m, 5H) , 1.58-1.64 (m, IH) , 1.70-1.80 (m, 4H) , 3.30 (s, 3H) , 3.41-3.51 (m, IH) , 7.50-7.55 (b, IH) , 7.80 (d, 2H) , 8.00 (d, 2H) , 8.10-8.18 (b, IH) . MS (m/z) / M+l =301/302 HPLC (uv purity, χ = 214 nm) = 99.9% The compounds of formula (I) disclosed in the examples are summurized in the following table: \Έ £ WLr- \% 15k \&T 1^7- i 1 7 Biological results In vitro inhibition of the phosphodiesterase 7 and of other phosphodiesterases The capacity of the compounds of the invention to inhibit cyclic nucleotide phosphodiesterases was evaluated by measuring their ICso (concentration necessary to inhibit the enzymatic activity by 50 %) . PDE3A3, PDE4D3, PDE7A1 were cloned and expressed in insect cells Sf21 using the baculovirus expression system. The source of PDE103 and of PDE503 were human cell lines (respectively TPH1 human monocytes and MCF7 human Caucasian breast adenocarcinoma) . The various types of phosphodiesterases were obtained partially purified on an anion exchange column (Mono Q) according to a method adapted from avan B.E.,Lakey T., Houslay M.D. Biochemical Pharmacology, 1989, 38 (22), 4123-4136. Measurement of the enzymatic activity for the various types of PDE was then made according to a method adapted from .J. Thompson et al . 1979, Advances in Cyclic Nucleotide Research, Vol. 10 : 69-92, ed. G. Brooker et al . Raven Press, NY. The substrate used was cGMP for PDE1 and PDE5 and cAMP for PDE 3, PDE 4 and PDE 7. The substrate concentration was 0.2μM for PDE 1, PDE 3 and PDE 5, 0,25μM for PDE 4 and 50nM for PDE 7. The enzymatic reaction was stopped after 1 hour for PDE 1, PDE 3 and PDE 5 and 10 minutes for PDE 4 and PDE 7. In order to determine their IC50, compounds of the invention were assayed at 8 concentrations ranging from 0.03nM to lOOμM for PDE 4 and PDE 7 and at 6 concentration ranging from 0,lμM to 30μM for PDE 1, 3 and 5. 1 The IC 50 (μM) were determined for some of the compounds of the invention, and the results are summarised in the following table : ZOO These results show that the compounds of the invention inhibit PDE7 at very low concentrations, with some IC 50 values lower than lOOnM. The results of the assays with other PDE (1, 3, 4 and 5) show IC50 values often superior to lOμM. It demonstrates that compounds of the invention are strong and selective PDE7 inhibitors. References - M. Akbar Ali, S.E. Livingston, and D.J. Philipps, Inorganica Chimica Acta , 6, 11 (1972) - P. Molina, A. Tarraga, A. Espinosa ; Synthesis, 690 (1988) - P. Molina, A. Tarraga, A. Espinosa ; Heterocycles, vol.29, N°12 (1989) - R. Noto, P. Lo ' Meo, M. Gruttadauria, G. Werber ; J. Heterocyclic Chem. , 33, 863 (1996) - patent: Gulf oil corporation, WO 77 12352 - patent: Bayer AG, DE 44 18 066 Al . - patent: Gulf oil corporation, WO 80 1507

Claims: CLAIMS 1. A compound having,the following formula (I), in which - Y is 0 or S; - Rl is: C 4 -C 1 0 alkyl, C 2 -Cχo alkenyl, C 2 -Cιo alkynyl, cycloalkyl, cycloalkenyl , heterocycle, aryl, or a bicyclic group; each optionally substituted with one or several groups Xι-R, identical or different, in which: - X x is: a single bond, lower alkylene, C 2 -C 6 alkenylene, cycloalkylene, arylene or divalent heterocycle, and, R 4 is : 1) H, =0, N0 2 , CN, halogen, lower haloalkyl, lower alkyl, carboxylic acid bioisostere, 2) COOR 5 , C(=0)R 5 , C(=S)R 5 , S0 2 R 5 , S0R 5 , SO3R5, SR 5 , OR 5 , 3) C(=0)NR 7 R 8 , C(=S)NR 7 R 8 , C (=CH-N0 2 ) NR 7 R 8 , C(=N- CN)NR 7 R 8 , C(=N-S0 2 NH 2 )NR 7 R 8 , C(=NR 7 )NHR 8 , C(=NR 7 )R 8 , C(=NR 9 )NHR 8 , C(=NR 9 )R 8 , S0 2 NR 7 R 8 or NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from OH, R 5 , Re , C (=0) NR 5 R 6 , C (=0) R 5 , S0 2 R 5 , C (=NR 9 ) NHR 10 , C (=NR 9 ) Ri 0 , C (=CH-N0 2 ) NR 9 R 10 , C ( =N-S0 2 NH 2 ) NR 9 Rio , C (=N-CN) NR 9 R 10 or C ( =S) NR 9 R 10 ; - R2 is : lower alkyl, C 2 -Cio alkenyl, C 4 -C 10 alkynyl, cycloalkyl , cycloalkenyl, heterocycle, aryl; each optionally substituted with one or several groups which are the same or different and which are selected from: 1) H, carboxylic acid bioisostere, lower haloalkyl, halogen, 2) COOR5, 0R 5 , SO 2 R5, 3) SONR 13 R 12 , C(=0)NRnRi 2 or NR 11 R 12 in which R u and R 12 are the same or different and are selected from OH, R 5 , R 5 , C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 Rχo, C(=CH-NO 2 )NR 9 R 10 , C (=N-CNJ NR 9 Rι 0 , C(=N- SO 2 NH 2 )NR 9 R 10 , C(=NR 9 )NHRχo or C(=NR 9 )Rι 0 ; R3 is X 2 -R' 3 wherein: - X 2 is a single bond or, a group selected from C 1 -C 4 alkylene, C 2 -C 6 alkenylene, C 2 -C 6 alkynylene, each optionally substituted with one or several groups which are the same or different and which are selected from: 1) H, C 1 -C 3 alkyl, C 3 -C 4 cycloalkyl, aryl, heterocycle, =0, CN, 2) 0R 5 , =NR 5 or, i 3) NR 13 R 14 in which Rχ 3 and Rχ 4 are the same or different and are selected from R 5 , R 6 , C(=0)NR5R6, C(=0)R 5 , SO2R5, C(=S)NR 9 Rιo, C (=CH-N0 2 ) NR9R10 , C(=NR 9 )NHR 10 or C(=NR 9 )R 10 ; - R'3 is: cycloalkyl , cycloalkenyl, aryl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -Rι 7 , identical or different, in which: - X 3 is : a single bond, lower alkylene, C 2 -C 6 alkenylene, C 2 -C 6 alkynylene, cycloalkylene, arylene, divalent heterocycle or a divalent polycyclic group, and, - Rχ 7 is: 1) H, =0, N0 2 , CN, lower haloalkyl, halogen, cycloalkyl , 2) COOR 5 , C(=0)R 5 , C(=S)R 5 , S0 2 R 5 , SOR 5 , SO 3 R 5 , SR 5 , 0R 5 , 3) C(=0)NRι 5 Rιs, C(=S)NRι 5 Ri 6 , C (=N-CN)NRι 5 Rι 6 , C(=N- S0 2 NH 2 )NR 15 R 1S , C(=CH-N0 2 )NR 15 R ιe , S0 2 NRι 5 Rι 6 , C(=NR 15 )NHR 16 , C(=NR 15 )Rιs, C (=NR 9 ) NHRι S , C(=NR 9 )Rι 6 or NR 15 R 16 in which R 15 and Ris are the same or different and are selected from , OH, R 5 , Rs, C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 Rι 0 , C(=CH- N0 2 )NR 9 Rιo, C(=N-CN)NR 9 R 10 , C (=N-S0 2 NH 2 ) NR 9 Rχ 0 , C(=NR 9 )NHRιo or C(=NR 9 )Rι 0 4) heterocycle optionally substituted with one or several groups R 5 ; R 5 and Re are the same or different and are selected from : - H, - lower alkyl, C 2 -C 6 alkenyl, C -C6 alkynyl; - X 4 -cycloalkyl, X 4 -cycloalkenyl, X 4 -aryl, X 4 -heterocycle or X 4 -polycyclic group, in which X 4 is a single bond, lower alkylene or C 2 -Cg alkenylene; each optionally substituted with one or several groups which are the same or different and which are selected from: halogen, =0, COOR 2 0, CN, OR20, lower alkyl O - optionally substituted with OR20, O-lower alkyl optionally sustituted with OR 2 o, C(=0) -lower alkyl, lower haloalkyl, X 5 -N-Rι 8 in which X 5 is a single bond or lower alkylene and R 18 , Rχ 9 and R20 are the same or different and are selected from H or lower alkyl ; Xs-heterocycle, X 6 -aryl, X 6 -cycloalkyl, X s - cycloalkenyl, Xβ-polycyclic group in which Xε is selected from a single bond or lower alkylene, these groups being optionally substituted with one or several groups, identical or different, selected from halogens, COOR21, OR 2 ι,or (CH 2 )nNR 2 ιR22 in which n is 0, 1 or 2 and R21 and R22 are the same or different and are selected from H or lower alkyl; R 9 is selected from H, CN, OH, lower alkyl, O-lower alkyl, aryl, heterocycle, S0 2 NH 2 or X 5 -N-Rι 8 in which X 5 is a Rl9' single bond or lower alkylene and Rχ 8 and Rχ 9 are the same or different and are selected from H or lower alkyl; Rio is selected from hydrogen, lower alkyl-, cyclopropyl or heterocycle; or a pharmaceutically acceptable derivative thereof, with the proviso that, , - when Rl is phenyl, it bears at least one substituent other than H, - when X 2 is a single bond and both Rl and R τ 3 are phenyl, each of Rl and R' 3 bear at least one substituent other than H, - when X 2 is a single bond and R' 3 is phenyl, R'3 is not substituted by an ester or a carboxylic acid in the ortho position, - the atom of R3 which is linked to the thiadiazole group is a carbon atom, with the exclusion of the following compounds, 1-Phenyl-l- [4-phenyl-5- (5-trifluoromethyl-2H- [1, 2, 4] triazol- 3-ylimino) -4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -methanone, 1- [4-Phenyl-5- (5-trifluoromethyl -2H- [1, 2 ,4] triazol-3- ylimino) -4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -l-thiophen-2-yl- ethanone, 1-Phenyl -1- (4-phenyl-5-p-tolylimino-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -methanone, Cyclohexyl- [3- (2,4, 6-trichloro-phenyl) -5- (2,3, 3-trimethyl- cyclopent-1-enylmethyl) -3H- [1, 3 ,4] thiadiazol -2 -ylidene] - amine, 2- (3,5-Diphenyl-3H- [1, 3 ,4] thiadiazol-2 -ylideneamino) -1,4- diphenyl-but-2-ene-l, 4-dione, 2- [3-Phenyl-5- (1-phenyl-methanoyl) -3H- [1,3,4] thiadiazol-2- ylideneamino] -but-2-enedioic acid dimethyl ester, 2- [5- (1-Phenyl-methanoyl) -3-p-tolyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -but-2-enedioic acid dimethyl ester, and, 2- [3- (4-Chloro-phenyl) -5- (1-phenyl -methanoyl) -3H- [1,3,4] thiadiazol -2 -ylideneamino] -but-2-enedioic acid dimethyl ester. 2. A compound according to claim 1 in which Rl, R2, R3 and Y are as defined in claim 1 with the proviso that, when R2 is a phenyl, uns.ubstituted or substituted whith 1 to 3 chorine or with a methyl, then R3 does not represent C(=0)- phenyl , C (=0) -thienyl , phenyl or CH 2 - (2,3,3 -trimethyl- cyclopent-1-enyl) . 3. A compound of formula (I) as defined in claim 1 or 2 , in which Rl is : C -C 6 alkyl, cycloalkyl , cycloalkenyl , heterocycle, aryl , or a bicyclic group; each optionally substituted with one or several groups Xι-,R , identical or different, in which: - X is a single bond, a divalent heterocycle or a lower alkylene, and, - R 4 is selected from: 1) H, =0, halogen, CN, lower haloalkyl, preferably lot? CF 3 , lower alkyl, carboxylic acid bioisostere, 2 ) COOR 5 , S0 2 R 5 , OR 5 , C (=0) R 5 3 ) C (=0) NR 7 R 8 , S0 2 NR 7 R 8 or NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from R 5 , Re , C (=0) NR 5 R 6 , C (=0) R 5 , S0 2 R 5 , C (=NR 9 ) NHRι 0 , C (=NR 9 ) Rιo or C (=S) NR 9 Rιo, wherein R 5 is selected from hydrogen or lower alkyl, optionally substituted with OH, and Re, R 9 and Rio are identical or different and are selected from hydrogen or lower alkyl. 4. A compound as defined in any one of claims 1 to 3 in which R2 is lower alkyl. 5. A compound as defined in any one of claims 1 to 4 in which R3 is X 2 -R' 3 wherein, - X 2 is a single bond, C-C 4 alkylene, C 2 -C6 alkenylene or C2-C6 alkynylene, and, - R'3 is: cycloalkyl, cycloalkenyl , aryl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -Rι 7 , identical or different, in which: - X 3 is a single bond or lower alkylene, and, Rι 7 is : 1) H, =0, N0 2 , CN, lower haloalkyl, halogen, cycloalkyl, 2) COOR 5 , C(=0)R 5 , C(=S)R 5 , SO2R5, SOR5, SO3R5, SR 5 , 0R 5 , 3) C(=0)NR 15 Ri 6 , C(=S)NRi 5 Ri 6 , C (=N-CN) NRι 5 Rι 6 , C(=CH-N0 2 )NRι 5 R 16 , S0 2 NRi 5 Ri 6 , C (=NR 15 ) NHRι 6 , C(=NRι 5 )Rιs, C(=NR 9 )NHRιs, C(=NR 9 )Rι S or NR 15 Rι 6 in which R 15 and Rι 6 are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 Rιo, C(=CH-N0 2 )NR 9 Rιo, C (=N-CN)NR 9 Rι 0 , 2 >7 C(=NR 9 )NHR 10 or C(=NR 9 )Rιo, 4) heterocycle optionally substituted with one or several groups R 5 . 6. A compound as defined in any one of claims 1 to 5, in which Rl is : cycloalkyl, preferably cyclohexane, cycloalkenyl , aryl, preferably phenyl, or a bicyclic group; each optionally substituted with one or several groups X1-R4, identical or different, in which: - Xi is a single bond or a divalent heterocycle, and, - R 4 is selected from: 1) H, halogen, CF 3 , =0, 2 ) COOR 5 , 0R 5 , 3) C(=0)NR 5 R 6 . wherein R 5 and Rε are identical or different and are selected from hydrogen or methyl. 7. A compound as defined in any one of claims 1 to 6, in which R2 is CH 3 . 8. A compound as defined in any one of claims 1 to 7 in which R3 is X 2 -R' 3 wherein, - X 2 is a single bond, Cι-C 4 alkylene or C 2 -C 6 alkenylene, and, - R'3 is: cycloalkyl, aryl, preferably phenyl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -Rι 7 , identical or different, in which: - X 3 is a single bond or -CH2-, and, - Rχ 7 is : 1) H, CN, CF 3 , halogen, N0 2 , 2) COOR5, SO 2 R5, OR 5 , C(=0)R 5 , 3) S0 2 NRχ 5 Rι 6 or NR 15 Rι 6 in which Rχ 5 and Ri 6 are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5/ S0 2 R 5 , C(=S)NR 9 Rχ 0 , C(=CH-N0 2 )NR 9 Rχo, C (=NR 9 )NHRι 0 , C(=NR 9 )Rχo or C (=N-CN)NR 9 Rιo, 4) heterocycle optionally substituted with one or several groups R 5 . 9. A compound according to claims 3, 4 and 5. 10. A compound according to claims 6, 7 and 8. 11. A compound as defined in claim 1 in which Rl is: cyclohexane, phenyl or a bicyclic group; each optionally substituted with one or several groups Xι-R , identical or different, in which: - Xi is a single bond or a divalent heterocycle, and, - R 4 is selected from: 1) H, halogen, CF 3 , 2) COOH, OH, 3) C(=0)NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from H or lower alkyl, R2 is CH 3 , and, R3 is X 2 -R-' 3 wherein, - X 2 is a single bond, Cχ-C alkylene or C 2 -C 6 alkenylene, and, - R'3 is: phenyl heterocycle, or a polycyclic group; each optionally substituted with one or several groups X3-Rι , identical or different, in which: - X 3 is a single bond, and, - Rχ 7 is : 1) CN, OH, CF 3 , =0, Cχ-C 6 alkoxy, halogen, 2) COOR5, S0 2 R 5 , 3) C(=0)NRχ 5 Rχ6, S0 2 NRi 5 Ri 6 or NRι 5 R ls in which R 15 and Rχ 6 are the same or different and are selected from OH, C(=0)R ε , C(=0)NR 5 R s , R 5 or R 6 , 4) heterocycle optionally substituted with one or several groups R 5 . • 12. A compound as defined in any one of claims 1 to 11 in which Y is S . 13. A compound as defined in any one of claims 1 to 11 in which Y is 0. 14. A compound selected from the group consisting of: 3- [5- (4-Chloro-phenyl) -3 -methyl-3H- [1,3, 4] thiadiazol-2- ylideneamino] -benzoic acid, (IR*, 2R*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [-1,3,4] thiadiazol-2-ylideneamino] -cyclohexanecarboxylic acid, (S) -2- [5- (4-Chloro-phenyl) -3 -methyl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino] -2 -phenyl-ethanol, 2- {2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino] -phenyl} -ethanol, {l- [5- (4-Chloro-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -cyclopentyl } -methanol , 3- [5- (4-Chloro-phenyl) -3 -methyl-3ff- [1,3,4] thiadiazol-2- ylideneamino] -cyclohexanecarboxylic acid, 5- [5- (4-Chloro-phenyl) -3-methyl-3H [1, 3 , 4] thiadiazol-2- ylideneamino] -2 -fluoro-benzoic acid, 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino] -2, 5, 6-trifluoro-benzoic acid, [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3,4] thiadiazol-2- ylidene] -propyl-amine, (S) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino] -butan-1-ol, Z \ o [5- (4-Chloro-phenyl) -3-methyl-3ff- [1, 3 , 4] thiadiazol-2- ylidene] -eyelobutyl-amine, 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3,4] thiadiazol-2- ylideneamino] -azepan-2-one, [5- (4-Chlorό-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylidene] -cyclopentyl-amine, [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylidene] -cycloheptyl-amine, (S) -2- [5- (4-Chloro-phenyl) -3-methyl -3H- [1, 3, 4] thiadiazol-2- ylideneamino] -3-methyl-butan-l-ol, 2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -2-methyl-propan-1-ol , tert-Butyl- [5- (4-chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylidene] -isopropyl-amine, 4- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid, [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylidene] - (1-ethyl-propyl) -amine, 4- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiad . iazol-2- ylideneamino] -phenol, N- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3,4] thiadiazol-2- y1idene] -eye1ohexane-1, 2-diamine, [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylidene] - (4-fluoro-phenyl) -amine, N- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3,4] thiadiazol-2- ylidene] -cyclohexane-1, 4-diamine, (IR*, 2S*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol, [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylidene] - (4-trifluoromethyl-phenyl) -amine, 3- [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzoic acid, 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -phenol, 5- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino] -2-hydroxy-benzoic acid, (1-Aza-bicyclo [2.2.2] oct-3-yl) - [5- (4-chloro-phenyl) -3- methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, 2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -phenol, (R) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino] -butan-l-ol, [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylidene] - (3-fluoro-phenyl) -amine, (3-Chloro-phenyl) - [5- (4-chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, {3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -phenyl} -acetic acid, 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [-1, 3,4] thiadiazol-2- ylideneamino] -benzamide, Bicyclo [2.2.1]hept-2-yl- [5- (4-chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, (IR*, 2R*) -2- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol, 5- (5-Cyclohexyl-3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino) -2-methoxy-phenol, 3- (5-Cyclohexyl-3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino) -benzoic acid, 3- [5- (4-Chloro-phenyl) -3 -methyl-3H- [1, 3, 4] thiadiazol-2- ylideneamino] -4-hydroxy-benzoic acid, (5-Cyclohexyl-3-methyl-3H- [1, 3 ,4] thiadiazol-2-ylidene) - (3- methanesulfonyl-phenyl) -amine, (IR*, 2R*) -2- [5- (4-Methanesulfonyl-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2 -ylideneamino] -cyclohexanol, Cyclohexyl- [5- (2, 4-dichloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, [5- (2-Chloro-phenyl) -3 -methyl-3H- [1, 3 , 4] thiadiazol-2- ylidene] -cyclohexyl-amine, Cyclohexyl- [3-methyl-5- (4-trifluoromethyl-phenyl) -3H- [1,3,4] thiadiazol-2-ylidene] -amine, Cyclohexyl- (3-methyl-5-pyridin-4-yl-3H- [1, 3 , 4] thiadiazol-2- ylidene) -amine, [5- (3-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylidene] -cyclohexyl-amine, 2-/Z. 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile, Cyclohexyl- [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, [3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -dimethyl-amine, Cyclohexyl- [5- (3-methoxy-4-nitro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, 2,4-Dichloro-5- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide, Cyclohexyl- (3-methyl-5-thiophen-3-yl-3H- [1,3,4] thiadiazol- 2-ylidene) -amine, Cyclohexyl- [5- (3 , 5-dichloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, Cyclohexyl- [5- (2-ethyl-5-methyl-2H-pyrazol-3-yl) -3-methyl- 3H- [1,3,4] thiadiazol-2-ylidene] -amine, [5- (3-Chloro-2, 6-dimethoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine, Cyclohexyl- (5-isoxazol-5-yl-3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene) -amine, Cyclohexyl- [3-methyl-5- (5-pyridin-2-yl-thiophen-2-yl) -3H- [1,3,4] thiadiazol-2-ylidene] -amine, 5- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -2-methoxy-benzene-l,3-diol; compound with trifluoromethanesulfonic acid, 5- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -2, 3-dimethoxy-phenol, compound with trifluoro-methanesulfonic acid [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 , 4] thiadiazol-2- ylidene] -cyclohexyl-amine, 2-Chloro-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol-2-yl) -6-methoxy-phenol ; compound with 1,1, 1-trifluoro-methanesulfonic acid, 2-Chloro-5- (5-cyclohexylimino- -methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N,N-diethyl- benzenesulfonamide, 2J > {5- [4-Chloro-3- (4-methyl-piperazine-l-sulfonyl) -phenyl] -3 -- methy1-3H- [1,3,4] thiadiazol-2-ylidene} -cyclohexyl- mine, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N-pyridin-4-ylmethyl- benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-morpholin-4-yl-ethyl) - benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- (2-morpholin-4-yl-ethyl) - benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N-isopropyl-N- (2-morpholin-4-yl- ethyl) -benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- [2- (2-methoxy-ethoxy) - ethyl] -benzenesulfonamide, C-Chloro- (cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (dimethylamino-hydroxy-propyl) -N- ethyl-benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- ■ [1,3,4] thiadiazol-2-yl) -N- (2,3-dihydroxy-propyl) -N-ethyl- ■ benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- (2 -hydroxy-3-pyrrolidin- 1-yl-propyl) -benzenesulfonamide, 2-Chloro-5- (cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-diethylamino-ethyl) -N-ethyl- benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-dimethylamino-propyl) -N-ethyl- benzenesulfonamide, [5- (4-Chloro-phenyl) -2-cyclohexylimino- [1,3 ,4] thiadiazol-3- yl] -acetic acid methyl ester, 3- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester, 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid, 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-hydroxy-ethyl) -benzamide, 3- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-methyl-benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzene-1, 2-diol, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -2 , 6-dimethoxy-phenol , 6- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -pyridin-2-ol, 5- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzene-1, 2 , 3-triol, 2- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -quinolin-8-ol, Cyclohexyl- (3-methyl-5-pyrazin-2-yl-3H- [1,3, 4] thiadiazol-2- ylidene) -amine, 5- [(E) -2- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -vinyl] -2-methoxy-phenol, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -2-methoxy-phenol, Cyclohexyl- (3-methyl-5-quinolin-8-yl-3H- [1,3,4] thiadiazol- 2-ylidene) -amine, [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3, 4] thiadiazol-2-yl) -phenyl] -dimethyl-amine, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide, [5- (5-Chloro-lH-indol-2-yl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene] -cyclohexyl-amine; compound with trifluoromethanesulfonic acid, 2- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3 ,4] thiadiazol-2-yl) -phenol; compound with 1,1,1- trifluoro-methanesulfonic acid, 5- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -2-methoxy-phenol , compound with 1, 1, 1-trifluoro-methanesulfonic acid, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol-2-yl) -phenol, compound with 1,1,1- trifluoro-methanesulfonic acid, Cyclohexyl- [5- (3,4-dimethoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -amine, [5- (3-Bromo-4-methoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -cyclohexyl-amine, Cyclohexyl- [5- (4-methoxy-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] -amine, Cyclohexyl- (3-methyl-5-phenyl-3H- [1,3,4] thiadiazol-2- ylidene) -amine, 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenol, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-hydroxy-benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2H-tetrazol-5-yl) -benzamide hydrochloride salt , 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N-quinolin-8-yl-benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N- (2, 6-dimethoxy-pyridin-3-yl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N-isopropyl-benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1, 3 ,4] thiadiazol- 2-yl) -N-ethyl-benzamide, Cyclohexyl- {5- [4- (l-ethyl-lH-tetrazol-5-yl) -phenyl] -3- methyl-3H- [1, 3 , 4] thiadiazol-2-ylidene} -amine, 2Jfe 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro [1,3,4] thiadiazol- 2-yl) -N- (2-dimethylamino-ethyl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro [1,3,4] thiadiazol- 2-yl) -N-pyridin-4-ylmethyl-benzamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4 , 5- dihydro [1,3,4] thiadiazol-2-yl) -N,N-diethyl- benzenesulfonamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-isobutyl-benzamide, 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N-methyl-benzamide, 4- (Cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2- yl) -N- (2-dimethylamino-ethyl) -N-methyl-benzamide, [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -1- (3-hydroxymethyl- piperidin-1-yl) -methanone, 2- [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3 ,4] thiadiazol-2-yl) -benzoylamino] -3- (4-hydroxy-phenyl) - propionic acid tert-butyl ester, 2- ({l- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -methanoyl} -amino) -3- (4- hydroxy- henyl) -propionic acid, compound with 2,2,2- trifluoro-acetic acid, (S) -2- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3 ,4] thiadiazol-2-yl) -benzoylamino] -propionic acid tert- butyl ester, (S) -2- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoylamino] -propionic acid; compound with 2, 2, 2-trifluoro-acetic acid, [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - (4-pyridin-2-yl-piperazin- 1-yl) -methanone, [ - (5-Cyclohexylimino-4-methyl-4 , 5_-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - [4- (4-fluoro-phenyl) - piperazin-1-yl] -methanone, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (3 , 4 , 5-trimethoxy-benzyl) - benzamide, [4 - (5-Cyclohexylimino-4 -methy zl-n4-, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - (4-pyrimidin-2-yl- piperazin-1-yl) -methanone, [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] - (4-methyl-piperazin-l-yl) - methanone, 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N- [3- (4-methyl-piperazin-l-yl) - propyl] -benzamide, 4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (1-ethyl-pyrrolidin-2 -ylmethyl) - benzamide, 4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-pyridin-3 -ylmethyl-benzamide, N-Benzyl-4- (5-cyclohexylimino-4-methylτ4 , 5-dihydro- [1,3,4] thiadiazol-2 -yl) -benzamide, N- (1-Benzyl-piperidin-4-yl) -4- (5-cyclohexylimino-4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-ethyl-2H-pyrazol-3-yl) - benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-morpholin-4-yl-ethyl) - benzamide, [5- (4- ( (N-cyano-N' -ethylmorpholine) -carboximidamide) - phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2 -ylidene] - eye1ohexy1-amine , 4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2 -pyrrolidin-1-yl-ethyl) - benzamide, Cyclohexyl- (3 -methyl-5-pyridin-3-yl-3H- [1,3,4] thiadiazol-2- ylidene) -amine, 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide, (5-Benzo[l,3]dioxol-5-yl-3-methyl-3H- [1,3,4] thiadiazol-2- ylidene) -cyclohexyl-amine, Cyclohexyl- [3-methyl-5- (3,4, 5-trimethoxy-phenyl) -3H- [1,3,4] thiadiazol-2 -ylidene] -amine, ■ Z\ t> 4- (5-Cyclopentylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile, 4- (5-Cycloheptylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile, 4- [5- (4-Fluoro-phenylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile, 4- [5- (3-Hydroxy-phenylimino) -4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile, 5- [5- (4-Cyano-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -2-fluoro-benzoic acid, 4- [4-Methyl-5- (cis-4-methyl-cyclohexylimino) -4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile, 4- [4-Methyl-5- (trans-4-methyl-cyclohexylimino) -4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile, 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile, 4- [5- (Bicyclo [2.2.1] hept-2-ylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile, 4- [5- ( (IR*, 2R*) -2-Hydroxy-cyclohexylimino) -4-methyl-4 , 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzonitrile, 4- [5- ( (IR*, 2S*) -2-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3 ,4] thiadiazol-2-yl] -benzonitrile, 4- [5- ( (IR*, 3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3,4] thiadiazol-2-yl] -benzonitrile, 4- [5- ( (IR*, 3S*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3,4] thiadiazol-2-yl] -benzonitrile, (IR*, 3R*) ) -3- [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanol, 4- [5- (IR*, 3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4 , 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzoic acid, 4- [5- ( (IR*, 3R*) -3-hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3 ,4] thiadiazol-2-yl] -N- (2-morpholin-4-yl-ethyl) • benzamide, 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzoic acid, 4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -N- (2-hydroxy-1, 1-dimethyl- ethyl) -benzamide, 4- [5- ( (IR*, 3R*) -3 -Hydroxy-cyclohexylimino) -4-methyl-4 , 5- dihydro- [1, 3 ,4] thiadiazol-2-yl] -N- (2-hydroxy-l, 1-dimethy1- ethyl) -benzamide, N-tert-Butyl-4- [5- ( (IR*, 3R*) -3-hydroxy-cyclohexylimino) -4- methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, N- (l,l-dimethyl-3-oxo-butyl) -4- [5- (IR*, 3R*) -3-hydroxy- cyclohexylimino) -4-methyl-4, 5-dihydro- [1,3 ,4] thiadiazol-2- yl] -benzamide, N- (2-Cyano-l,2,2-trimethyl-ethyl) -4- [5- (IR*, 3R*) -3- hydroxy-cyclohexylimino) -4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, l-{4- [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3 ,4] thiadiazol-2-yl] -benzoylamino} - cyclopropanecarboxylic acid methyl ester, 4- (5-Cyclopentylimino-4-methyl-4, 5-dihydro- [1, 3,4] thiadiazol-2-yl) -benzamide, 4- (5-Cycloheptylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 4- [5- (4-Fluoro-phenylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 4- [5- (3-Hydroxy-phenylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 5- [5- (4-Carbamoyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -2-fluoro-benzoic acid, 4- [4-Methyl-5- (4-methyl-cyclohexylimino) -4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 4- [5- ( -Hydroxy-cyclohexylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 4- [5- (Bicyclo [2.2.1] hept-2-ylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 4- [5- ( (1R*,2R*) -2-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3 ,4] thiadiazol-2-yl] -benzamide, 4- [5- ( (lR*,2S*)"-2- 1 Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [l, 3,4] thiadiazol-2-yl] -benzamide, 4- [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 4- [5- ( (1R*,3S*) -3-Hydroxy-cyclohexylimino) -4-methyl-4 , 5- dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 4- [4-Methyl-5- (3 -oxo-cyclohexylimino) -4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 4- [5- (3, 3-Difluoro-cyclohexylimino) -4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, 4- [5- ( (1R*,3R*) -3-Fluoro-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3 ,4] thiadiazol-2-yl] -benzamide, 4- [5- (Cyclohex-3-enylimino) -4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl] -benzamide, (lR*,3R*)-3-{3-Methyl-5- [4- (lH-tetrazol-5-yl) -phenyl] -3H- [1,3,4] thiadiazol-2-ylideneamino} -cyclohexanol, 3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -2-hydroxy-benzoic acid, 3- [5- (4-Cyano-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid, 3- [5- (4-carbamoyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid, 2-Fluoro-5- [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzoic acid, 3- [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -cyclohexanecarboxylic acid, [5- (4-methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -piperidin-1-yl amine, [5- (4-Methanesulfonyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] - (tetrahydro-pyran-4-yl) -amine, 3- [5- (4-Acetylamino-phenyl) -3-methyl-3H- [1, 3 ,4] thiadiazol- 2-ylideneamino] -benzoic acid, N-{4- [5- (trans-4-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1, 3 ,4] thiadiazol-2-yl] -phenyl} -acetamide, N-{4- [5- ( (1R*,3S*) -3-Hydroxy-cyclohexylimino) -4-methyl-4 , 5- dihydro- [1, 3 ,4] thiadiazol-2-yl] -phenyl} -acetamide, N-{4- [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1 ,'3 , 4] thiadiazol-2-yl] -phenyl} -acetamide, N- { 5 - [5- ( (1R*,3R*) -3-Hydroxy-cyclohexylimino) -4-methyl-4, 5- dihydro- [1,3,4] thiadiazol-2-yl] -pyridin-2-yl} -acetamide, 3- [5- (4-Chloro-phenyl) -3-methyl-3H/- [1,3,4] thiadiazol-2- ylideneamino] -benzonitrile, [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 ,4] thiadiazol-2 - ylidene] - [3- (lH-tetrazol-5-yl) -phenyl] -amine, 3- [5- (4-Chloro-phenyl) -3 -methyl-3H- [1, 3 ,4] thiadiazol-2- ylideneamino] -N-hydroxy-benzamidine, 3-{3- [5- (4-Chloro-phenyl) -3-methyl-3H- [1, 3 ,4] thiadiazol-2- ylideneamino] -phenyl}- [1,2,4] oxadiazol-5-ol, [5- (4-Bromo-3-methyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol- 2-ylidene] -cyclohexyl-amine, 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3 , 4] thiadiazol-2-yl) -2 -methyl-benzonitrile, 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2 -yl) -2 -methyl-benzamide, [5 (4-Bromo-3-methoxy-phenyl) -3-methyl-2, 3 -dihydro- [1 3,4] thiadiazol-2-yl] -cyclohexyl-amine, 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2 -yl) -2-methoxy-benzamide, 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -2-hydroxy-benzamide, 4- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -2-nitro-benzoic acid methyl ester, 2-Amino-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -benzoic acid methyl ester, 2-Acetylamino-4- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1 3,4] thiadiazol-2-yl) -benzoic acid methyl ester, 2-Amino-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1 3 ,4] thiadiazol-2-yl) -benzamide, 7- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -3H-quinazolin-4-one, 7- 5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -q inazolin-4-ylamine, 7- 5-Cyclohexylimino-4-methyl-4,5-dihydro- [1 3 ,4] thiadiazol-2-yl) -lH-quinazoline-2 , 4-dione, 4- 5 i -Cyclohexylimino-4-methyl-4, 5-dihydro- [1 3,4] thiadiazol-2-yl) -2-methoxy-benzenesulfonamide, 5- 5-Cyclohexylimino-4-methyl-4,5-dihydro- [1 3,4] thiadiazol-2-yl) -2-methoxy-benzenesulfonamide, 3- 5- (3-Cyano-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2' ylideneamino] -benzoic acid methyl ester, 3- [5- (3 -Cyano-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid, 3- [3-Methyl-5-pyridin-2-yl-3H- [1, 3 , 4] thiadiazol-2- ylideneamino] -benzoic acid, 3- [5- (4-Chloro-3-sulfamoyl-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylideneamino] -benzoic acid, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzonitrile, Cyclohexyl- {3-methyl-5- [4- (lH-tetrazol-5-yl) -phenyl] -3H- [1,3,4] thiadiazol-2-ylidene} -amine, Cyclohexyl- [3-methyl-5- (4-nitro-phenyl) -3H- [1,3,4] thiadiazol-2-ylidene] -amine, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3, 4] thiadiazol-2-yl) -phenylamine, [5- (4- (N-cyano-N 1 - (2-dimethylaminoethyl) -carboximidamide) - phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] - eye1ohexy1-amine, N- [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -acetamide, [5- (4- (bis-ethylsulfonylamino) -phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine, . . [5- (4- (1- (2-dimethylaminoethyl) amino-2-nitro-vinylamino) - phenyl) -3-methyl-3H- [1,3, 4] thiadiazol-2-ylidene] - cyclohexyl-amine, (E) -N 1 - [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -2-nitro-ethene-l, 1-diamine, [5- (N-cyano-N' -methyl-4-carboximidamide-phenyl) -3-methyl- 3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine, [5- (4- (N-cyano-N' -amino- carboximidamide) -phenyl) -3-methyl- 3H- [1,3,4] thiadiazol-2-ylidene] -cyclohexyl-amine, Ethanesulfonic acid [4- (5-cyclohexylimino-4-methyl-4, 5- dihydro- [1, 3 , 4] thiadiazol-2-yl) -phenyl] -amide, [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -urea, 1- [4- (Cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol- 2-yl) -phenyl] -3- (2-dimethylamino-ethyl) -urea, 2-Chloro-4- (5-cyclohexylimino-4-methyl-4,5-dihydro- [1,3,4] thiadiazol-2-yl) -benzenesulfonamide, 2-Chloro-4- (5-cyclohexyliminό-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester, 2-Chloro-4- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3, 4] oxadiazol- 2-yl) -benzoic acid methyl ester, and, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3,4] oxadiazol- 2-yl) -benzamide. 15. A compound according to claim 14, selected from the group consisting of: 5- (5-Cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -2-methoxy-benzene-l, 3-diol ; compound with trifluoro-methanesulfonic acid, 5- (5-Cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -2, 3-dimethoxy-phenol; compound with trifluoro-methanesulfonic acid, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1, 3 , 4] thiadiazol-2-yl) -benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4,5- dihydro [1,3,4] thiadiazol-2-yl) -N,N-diethyl- benzenesulfonamide, {5- [4-Chloro-3- (4-methyl-piperazine-l-sulfonyl) -phenyl] -3- methyl-3H- [1,3,4] hiadiazol-2-ylidene} -cyclohexyl-amine, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-pyridin- -ylmethyl- benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-morpholin-4-yl-ethyl) - benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino- -methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- (2-morpholin-4-yl- 2 1^ ethyl).-benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-isopropyl-N- (2-morpholin-4-yl- ethyl) -benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-ethyl-N- [2- (2-methoxy-ethoxy) - ethyl] -benzenesulfonamide, C-Chloro- (cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (dimethylamino-hydroxy-propyl) -N- ethyl-benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2,3-dihydroxy-propyl) -N-ethyl- benzenesulfonamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -N-ethyl-N- (2-hydroxy-3-pyrrolidin- 1-yl-propyl) -benzenesulfonamide, 3- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N-quinolin-8-yl-benzamide, 4- (5-Cyclohexylimino-4-methyl-4 , 5- dihydro [1,3,4] thiadiazol-2-yl) -N- (2, 6-dimethoxy-pyridin-3- yl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N-isopropyl-benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N-ethyl-benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5- dihydro[l,3,4] thiadiazol-2-yl) -N- (2-dimethylamino-ethyl) - benzamide, 4- (5-Cyclohexylimino-4 ' -methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N-pyridin-4-ylmethyl- benzamide, 2-Chloro-5- (5-cyclohexylimino-4-methyl-4, 5- dihydro [1,3,4] thiadiazol-2-yl) -N,N-diethyl- benzenesulfonamide, T Xζ 4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-methyl-benzamide, 2- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoylamino] -3- (4-hydroxy- phenyl) -propionic acid tert-butyl ester, (S) -2- [4- (5-Cyclohexylimino-4-methyl-4,5-dihydro- [1, 3,4] thiadiazol-2-yl) -benzoylamino] -3- (4-hydroxy- phenyl) -propionic acid; compound with 2,2, 2-trifluoro- acetic acid, 4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (3,4, 5-trimethoxy-benzyl) - benzamide, 4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- [3- (4-methyl-piperazin-l-yl) - propyl] -benzamide, 4- (5-Cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -N-pyridin-3-ylmethyl-benzamide, N- (l-Benzyl-piperidin-4-yl) -4- (5-cyclohexylimino-4-methyl- 4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-ethyl-2H-pyrazol-3.-yl) - benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -N- (2-morpholin-4-yl-ethyl) - benzamide, 4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -N- (2-pyrrolidin-1-yl-ethyl) - benzamide, 3- [5- (4-carbamoyl-phenyl) -3 -methyl-3H- [1,3,4] thiadiazol-2- ylideneamino] -benzoic acid, [5- (4-Chloro-phenyl) -3-methyl-3H- [1,3,4] thiadiazol-2- ylidene] - [3- (lH-tetrazol-5-yl) -phenyl] -amine, 2-Amino-4- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzoic acid methyl ester, 2-Amino-4- (5-cyclohexylimino-4-methyl-4 , 5-dihydro- [1,3,4] thiadiazol-2-yl) -benzamide, 7- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -3H-quinazolin-4-one, 17X 7- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -quinazolin-4-ylamine, , N- [4- (5-Cyclohexylimino-4-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2 -yl) -phenyl] -acetamide, and, 1- [4- (Cyclohexylimino-methyl-4, 5-dihydro- [1,3,4] thiadiazol-2-yl) -phenyl] -3- (2-dimethylamino-ethyl) - urea. 16. Pharmaceutical composition comprising a compound of formula (I) , wherein: - Y is 0 or S; - Rl is: Ci-Cxo alkyl, C 2 -Cχ 0 alkenyl, C 2 -Cχ 0 alkynyl, cycloalkyl , cycloalkenyl, heterocycle, > aryl, or a polycyclic group; each optionally substituted with one or several groups Xι-R 4 , identical or different, in which: - Xi is: a single bond, lower alkylene, C 2 -C 6 alkenylene, cycloalkylene, arylene or a divalent heterocycle, and, - R 4 is: 1) H, =0, N0 2 , CN, halogen, lower haloalkyl, lower ZZ7 alkyl, carboxylic acid bioisostere, 2) COOR5, C(=0)R 5 , C(=S)R 5 , SO 2 R5, S0R 5 , S0 3 R 5 , SR 5 , OR 5 , 3) C(=0)NR 7 R 8 , C(=S)NR 7 R 8 , C (=N-CN) NR 7 R 8 , C(=N- S0 2 NH 2 )NR 7 R 8 , C (=CH-N0 2 ) NR 7 R 8 , C(=NR 7 )NHR 8 , C(=NR 7 )R 8 , C(=NR 9 )NHR 8 , C(=NR 9 )R 8 , S0 2 NR 7 R 8 or NR 7 R 8 in which R 7 and R 8 are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , SO 2 R 5 , C(=NR 9 )NHRχo, C(=NR 9 )Rχo, C (=CH-NO 2 )NR 9 Rχ 0 , C(=N-SO2NH 2 )NR 9 R 10 , C (=N-CN) NR 9 Rχ 0 or C (=S)NR 9 R 10 ; R2 is : lower alkyl, C 2 -Cχo alkenyl, C 2 -Cχo alkynyl, cycloalkyl, cycloalkenyl , heterocycle, aryl ; each optionally substituted with one or several groups which are the same or different and which are selected from: 1) H, carboxylic acid bioisostere, lower haloalkyl, halogen, 2) COOR5, OR 5 , S0 2 R 5 , 3) S0 2 NRnRχ 2 , C(=0)NRχχRι 2 or NRχιRχ in which R lx and Rχ 2 are the same or different and are selected from OH, R 5 , R 6 , C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 R 10 , C(=:CH-NO 2 )NR 9 Rχ 0 , C (=N-CN)NR 9 R 10/ C(=N- SO 2 NH 2 )NR 9 Rχ 0 , C(=NR 9 )NHR 10 or C(=NR 9 )R 10 ; R3 is X 2 -R' 3 wherein: - X 2 is a single bond or, a group selected from C ! -C 4 alkylene, C 2 -C 6 alkenylene, C 2 -C 6 alkynylene, each optionally substituted with one or several groups which are the same or different and which are selected from: 1) H, Cχ-C 3 alkyl, C3-C 4 cycloalkyl, aryl, heterocycle, =0, CN, 2) OR 5 , =NR 5 or, 3) NR 13 R 14 in which R 13 and Rχ are the same or different and are selected from R 5 , Rg, C(=0)NR 5 R 6 , C(=0)R 5 , S0 2 R 5 , C(=S)NR 9 Rχ 0 , C(=CH-N0 2 )NR 9 Rχo, C(=NR 9 )NHRχ 0 or C(=NR 9 )Rχ 0 ; - R'3 is: cycloalkyl , cycloalkenyl , aryl, heterocycle, or a polycyclic group; each optionally substituted with one or several groups X 3 -Rχ 7 , identical or different, in which: - X 3 is: a single bond, lower alkylene, C 2 -C 6 alkenylene, cycloalkylene, arylene, a divalent heterocycle or a divalent polycyclic group, and, - R 17 is : 1) H, =0, N0 2 , CN, lower haloalkyl, halogen, carboxylic acid bioisostere, cycloalkyl, 2) COORs, C(=0)R 5 , C(=S)R 5 , S0 2 R 5 , S0R 5 , SO3R5, SR 5 , ' 0R 5 , 3) C(=0)NR 15 Ri 6 , C(=S)NRχ 5 Rχ 6 , C (=N-CN) NR 15 Rχ 6 , C.(=N- S0 2 H 2 ) Rι 5 Rι 6 , C (=CH-N0 2 ) NRχ 5 Rι 6 , SO 2 NR 1 5R 16 , C(=NRχ 5 )NHRi 6 , C(=NRι 5 )Rχ 6 , C (=NR 9 )NHRχ 6 , C(=NR 9 )Rχ 6 or NR 15 R 16 in which R 15 and Riβ are the same or different and are selected from OH, R 5 , Re, C(=0)NR S R 6 , C(=0)R 5 , SO 2 R5, C(=S)NR 9 Rιo, C(=CH- C(=NR 9 )NHRχ 0 or C(=NR 9 )Rχ 0 , 4) heterocycle optionally substituted with one or several groups R 5 ; wherein, Rs and Rg are the same or different and are selected from : - H, ' - lower alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl; - X 4 -cycloalkyl,. X 4 -cycloalkenyl, X 4 -aryl, X 4 -heterocycle or X 4 -polycyclic group, in which X is a single bond, lower alkylene or C 2 -C 6 alkenylene; each optionally substituted with one or several groups which are the same or different and which are selected from: halogen, =0, COOR20, CN, OR20, lower alkyl optionally substituted with OR 2 o, O-lower alkyl optionally sustituted with OR20, C(=0) -lower alkyl, lower haloalkyl, X 5 -N-R 18 in which X 5 is a single R19 bond or lower alkyl and Rχ 8 , R 19 and R20 are the same or different and are selected from H or lower alkyl ; - X 6 -heterocycle, Xε-aryl, X 6 -cycloalkyl, X 6 - cycloalkenyl, X 6 -polycyclic group in which β is selected from a single bond or lower alkylene, these groups being optionally substituted with one or several groups, identical or different, selected from halogens, COOR21, OR 2 ι,or (CH 2 )nNR 2 iR22 in which n is 0, 1 or 2 and R 2 ι and R22 are the same or ^ different and are selected from H or lower alkyl; -Rg is selected from H, CN, OH, lower alkyl, O-lower alkyl, aryl, heterocycle, S0 2 NH 2 or X 5 -N-Rχ 8 in which X 5 is, a 19 single bond or lower alkylene and. R 18 and Rχ 9 are the same or different and are selected from H or lower alkyl; Rχo is selected from hydrogen, lower alkyl, cyclopropyl or heterocycle; or a pharmaceutically acceptable derivative thereof, together with a pharmaceutically acceptable carrier, with the proviso that the compound of formula (I) is not 4- [2-Formylimino-5- (4-methoxy-phenyl) - [1,3,4] thiadiazol-3-yl] - butyric acid ethyl ester, or, 4- [5- (4-Chloro-phenyl) -2-formylimino- [1,3,4] thiadiazol-3-yl] - butyric acid ethyl ester. 17. A pharmaceutical composition according to claim 16, Z G comprising a compound of formula (I), in which Rl, R2, R3 and Y are as defined in claim 18, with the proviso that when Rl is C(=0)-H, then R2 does not represent (CH2) 3 -C (=0) OCH 2 CH 3 . 18. Pharmaceutical composition comprising a compound of formula (I) according to any one of claims 1 to 15, together with a pharmaceutically acceptable carrier. 19. A pharmaceutical composition according to claim 16, 17 or 18, for the treatment of a disease for which treatment by a PDE7 inhibitor is relevant . 20. Method for the treatment of a disease for. which treatment by a PDE7 inhibitor is relevant, comprising administering to a mammal, particularly a human, in need thereof, an effective amount of compound of formula (I) according any of claims 1 to 15. 21. Method according to claim 20, in which the disease to be treated is selected from T-cell-related diseases, autoimmune diseases, inflammatory diseases, _ respiratory diseases, CNS diseases, allergic diseases, • endocrine or exocrine pancreas diseases, or gastrointestinal diseases. 22. Method according to claim 20, in which the disease to be treated is selected from visceral pain, inflammatory bowel disease, osteoarthri is, multiple sclerosis, chronic obstructive pulmonary disease (COPD) , asthma, cancer, acquired immune deficiency syndrome (AIDS) or graft rejection. 23. Use of a compound of formula (I) according to any one of claims 1 to 15, for the manufacture of a medicament for the treatment of diseases for which treatment by a PDE7 inhibitor is relevant. 24. Use according to claim 23, in which the disease to be treated is selected from T-cell-related diseases, zzi autoimmune diseases, inflammatory diseases, respiratory diseases, CNS diseases, allergic diseases, endocrine or exocrine pancreas diseases, or gastrointestinal diseases. 25. Use according to claim 23, in which the disease to be treated is selected from visceral pain, inflammatory bowel disease, osteoarthritis, multiple sclerosis, chronic obstructive pulmonary disease (COPD) , asthma, cancer, acquired immune deficiency syndrome (AIDS) or graft rejection. 26. A compound of formula (I) as defined in any one of claims 1 to 15, as a medicament. 27. A process for the preparation of a 1,3,4- thiadiazole of formula (I) according to any one of claims 1 to 12, 14 or 15 in which Y is S, comprising the following steps : (a) reaction of a substituted hydrazine R2NHNH 2 in which R2 is as defined in claim 1, with carbon disulphide and MeX where X is a leaving group to obtain compound of formula 1 (b) reaction of the S-methyldithiocarbazate 1 with an acyl chloride R3C0C1 in which R3 is as defined in claim 1 to to obtain an acylated methyldithiocarbazate 2 (c) cyclization of the acylated methyldithiocarbazate 2 into a 1,3,4-thiadiazole 3 22>2- R2 (d) reaction of the 1,3,4-thiadiazole 3 with an amine RINH2 in which Rl is as defined in claim 1, to obtain the compound of formula (I) in which Y is S, (e) isolating the compound of formula (I) . 28. Process for the preparation of a 1,3,4-thiadiazole of formula (I) according to any one of claims 1 to 12, 14 or 15, in which Y is S, comprising the following steps: (a) reaction of a substituted hydrazine R2NHNH 2 in which R2 is as defined in claim 1, with a substituted isothiocyanate SCNR1 in which Rl is as defined in claim 1, to obtain the substituted thiosemicarbazide 5 (b) reaction of the thiosemicarbazide 5 with an aldehyde R3CHO in which R3 is as defined in claim 1, to obtain the thiosemicarbazone 6 (c) cyclization of the thiosemicarbazone 6 into the compound of formula (I) in which Y is S, (d) isolating the compound of formula (I) . 29. Process for the preparation of a 1,3,4-thiadiazole of formula (I) according to any one of claims 1 to 12, 14 or 15, in which Y is S, comprising the following steps: (a) reaction of a carboxylic acid R3COOH in which R3 is as defined in claim 1, with the following thiosemicarbazide 5' "10 to obtain the 1,3,4-thiadiazole 7 (b) reaction of the 1,3,4-thiadiazole 7 with R2X, in 15 which R2 is as defined in claim 1 and X is a leaving group to obtain the compound of formula (I) in which Y is S (c) isolating the compound of formula (I) . 30. Process for the preparation of a 1,3,4-thiadiazole 20 of formula (I) according to any one of claims 1 to 12, 14 or 15, comprising the following steps: (a) reaction of a carboxylic acid R3COOH, in which R3 is as defined in claim 1, with the following thiosemicarbazide 5 25 I i*- R2 I H 2 N C to obtain the final compound of formula I in which Y is S, (b) isolating the compound of formula (I) . 31. Process for the preparation of a 1, 3 ,4-oxadiazole of formula (I) according to any one of claims 1 to 11 or 13, in which Y is 0, comprising the following steps: (a) reaction of a substituted hydrazine R2NHNH2, in which R2 is as defined in claim 1, with a substituted isothiocyanate SCNRl, in which Rl is as defined in claim 1, to obtain the substituted thiosemicarbazide 5, R2 .N^S H 2 N HN^ Rl (b) reaction of the thiosemicarbazide 5 with R3- C(=0)C1, in which R3 is as defined in claim 1, to form the desired thiosemicarbazide 8 R2 8 (c) cyclization of the thiosemicarbazide 8 into the final compound of formula I in which Y is 0, (d) isolating the compound of formula (I) .

Inventors: ANDRIANJARA CHARLES, BERNARDELLI PATRICK, DUCROT PIERRE, LORTHIOIS EDWIGE, VERGNE FABRICE, ANDRIANJARA, CHARLES, BERNARDELLI, PATRICK, DUCROT, PIERRE, LORTHIOIS, EDWIGE, VERGNE, FABRICE
Applicants: ANDRIANJARA CHARLES, BERNARDELLI PATRICK, DUCROT PIERRE, LORTHIOIS EDWIGE, VERGNE FABRICE, WARNER LAMBERT CO, ANDRIANJARA, CHARLES, BERNARDELLI, PATRICK, DUCROT, PIERRE, LORTHIOIS, EDWIGE, VERGNE, FABRICE, WARNER-LAMBERT COMPANY
Application year: 2001
Main classification: C07D285
IPC codes: A61K31, A61P5, A61P11, A61P19, A61P25, A61P29, A61P31, A61P37, C07D271, C07D285, C07D417, C07D453