Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides and insecticides

Abstract: Certain cyclopropyl oxime ethers substituted by aryl and heterocyclic moieties possess broad spectrum fungicidal and insecticidal properties. These compounds are disclosed along with compositions containing these compounds and methods for controlling fungi and insects by the use of a fungitoxic or insecticidal amount of these compounds.

Description: The present invention relates to certain aryl cyclopropyl oxime ether structures, compositions containing these compounds and methods for controlling fungi and insects by the use of a fungitoxic or insecticidal amount of these compounds. Compounds having certain bis oxime ether structures have been disclosed in US 5,756,426. We have discovered certain new bis oxime ethers which possess a cyclopropane substituted by aryl and heterocyclic moieties. These novel derivatives possess broad spectrum fungicidal and insecticidal properties. The novel cyclopropyloxime ethers of the present invention have the Formula I: wherein X is N or CH; Y is O, S or NR 8 ; A is selected from the group consisting of hydrogen, halo, cyano, (C 1 -C 12 )alkyl, and (C 1 -C 12 )alkoxy; Z is O, N-OR 9 or N-R 10 ; R 1 and R 8 are independently selected from the group consisting of hydrogen and (C 1 -C 4 )alkyl; R 2 is selected from the group consisting of hydrogen, C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, cyano, (C 1 -C 4 )alkoxycarbonyl, aryl, aralkyl, heterocyclic, and heterocyclic(C 1 -C 4 )alkyl; R 3 and R 7 are each independently selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, heterocyclic and heterocyclic(C 1 -C 4 )alkyl, provided that at least one of R 3 and R 7 is aryl, aralkyl, heterocyclic, or heterocyclic(C 1 -C 4 )alkyl; R 4 , R 5 , and R 6 are each independently selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, halo, cyano, (C 1 -C 4 )alkoxycarbonyl, aryl, aralkyl, heterocyclic and heterocyclic(C 1 -C 4 )alkyl; R 9 is selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, (C 1 -C 4 )alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclic carbonyl, (C 1 -C 4 )alkoxycarbonyl, aryl, aralkyl, heterocyclic and heterocyclic(C 1 -C 4 )alkyl; R 10 is selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, heterocyclic or heterocyclic(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylcarbonyl, and (C 1 -C 4 )alkoxycarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclic carbonyl, (C 1 -C 4 )alkylaminocarbonyl, arylaminocarbonyl, N-R 8 R 9 , N=CR 11 R 12 , (C 1 -C 4 )alkylsulfonyl, N=cyclopropyl, N=cyclobutyl, N=cyclopentyl, N=cyclohexyl, and arylsulfonyl; R 11 and R 12 are each independently selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 1 -C 12 )alkoxy, halo(C 1 -C 12 )alkoxy, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, cyano, (C 1 -C 4 )alkoxycarbonyl, (C 1 -C 4 )alkylamino, aryl, aralkyl, heterocyclic, and heterocyclic(C 1 -C 4 )alkyl. The aforementioned (C 1 -C 12 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and (C 3 - C 7 )cycloalkyl groups may be optionally substituted with up to three substituents selected from the group consisting of nitro, halomethyl, (C 1 -C 4 )alkoxycarbonyl, and cyano. Unless otherwise limited, the following terms, as used herein, have the following meanings. The term "alkyl" means both branched and straight chain alkyl groups from 1 to 12 carbon atoms. Typical alkyl groups are methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, isobutyl, t-butyl, n-pentyl, isopentyl, n-hexyl, n-heptyl, isooctyl, nonyl, decyl, undecyl and dodecyl. The term haloalkyl refers to an alkyl group substituted with 1 to 3 halogens. The term "alkenyl" means an ethylenically unsaturated hydrocarbon group, straight or branched, having a chain length of 2 to 8 carbon atoms and 1 or 2 ethylenic bonds. The term "haloalkenyl" means an alkenyl group substituted with 1 to 3 halogen atoms. The term "alkynyl" means an unsaturated hydrocarbon group, straight or branched, having a chain length of 2 to 12 carbon atoms and 1 or 2 acetylenic bonds. The term "aryl" means phenyl or naphthyl, which maybe substituted with up to three substituents independently selected from the group consisting of halogen, cyano, trihalomethyl, phenyl, phenoxy, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkylthio, (C 1 -C 4 )alkylsulfoxide, halo(C 1 -C 4 )alkyl and halo(C 1 -C 4 )alkoxy. Typical aryl substituents include but are not limited to 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 4-bromophenyl, 2-methylphenyl, 3-methyphenyl, 4-methylphenyl, 2,4-dibromophenyl, 3,5-difluorophenyl, 2,4,6-trichlorophenyl, 2-chloronapthyl, 3-(trifluoromethyl)phenyl, 4-(trifluoromethyl)phenyl and 2-iodo-4-methylphenyl. The term "heterocyclic" means a substituted or unsubstituted 6 membered unsaturated ring containing one, two or three heteroatoms independently selected from oxygen, nitrogen and sulfur or to a bicyclic unsaturated ring system containing up to 10 atoms including one heteroatom selected from oxygen, nitrogen and sulfur. The term "heterocyclic" also refers to a 5-membered unsaturated ring containing one, two, or three heteroatoms independently selected from oxygen, nitrogen, and sulfur, preferably one or two heteroatoms. Examples of heterocycles include but are not limited to 2-, 3- or 4-pyridinyl, pyrazinyl, 2-, 4-, or 5-pyrimidinyl, pyridazinyl, pyrazole, triazolyl, imidazolyl, 2 or 3-thienyl, 2 or 3-furyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, quinolyl and isoquinolyl. If the heterocyclic ring is substituted there may be up to two substituents independently selected from (C 1 -C 4 ) alkyl, halogen, cyano, nitro, and trihalomethyl. The term "aralkyl" means a group having an alkyl chain and an aryl portion wherein the alkyl chain is from 1 to 10 carbon atoms and can be branched or straight chain, preferably a straight chain, with the aryl portion, as defined above, forming a terminal portion of the aralkyl moiety. Typical aralkyl moieties are optionally substituted benzyl, phenethyl, phenpropyl and phenbutyl moieties. Typical benzyl moieties are 2-chlorobenzyl, 3-chlorobenzyl, 4-chlorobenzyl, 2-fluorobenzyl, 3-fluorobenzyl, 4-fluorobenzyl, 4-trifluoromethylbenzyl, 2,4-dichlorobenzyl, 2,4-dibromobenzyl, 2-methylbenzyl, 3-methylbenzyl, and 4-methylbenzyl. Typical phenethyl moieties are 2-(2-chlorophenyl)ethyl, 2-(3-chlorophenyl)ethyl, 2-(4-chlorophenyl)ethyl, 2-(2-fluorophenyl)ethyl, 2-(3-fluorophenyl)ethyl, 2-(4-fluorophenyl)ethyl, 2-(2-methylphenyl)ethyl, 2-(3-methyl-phenyl)ethyl, 2-(4-methylphenyl)ethyl, 2-(4-trifluoromethylphenyl)ethyl, 2-(2,4-dichlorophenyl)-ethyl, 2-(3,5-dimethoxyphenyl)ethyl. Typical phenpropyl moieties are 3-phenylpropyl, 3-(2-chlorophenyl)propyl, 3-(3-chlorophenyl)propyl, 3-(4-chlorophenyl)propyl, 3-(2,4-dichloro-phenyl)propyl, 3-(2-fluorophenyl)propyl, 3-(3-fluorophenyl)propyl, 3-(4-fluorophenyl)propyl, 3-(2-methylphenyl)propyl, 3-(3-methylphenyl)propyl, 3-(4-methylphenyl)ethyl, 3-(4-trifluoromethylphenyl)propyl, 3-(2,4-dichlorophenyl)propyl and 3-(3,5-dimethylphenyl)propyl. Typical phenbutyl moieties include are 4-phenylbutyl, 4-(2-chlorophenyl)butyl, 4-(3-chlorophenyl)butyl, 4-(4-chlorophenyl)butyl, 4-(2-fluorophenyl)butyl, 4-(3-fluorophenyl)butyl, 4-(4-fluorophenyl)butyl, 4-(2-methylphenyl)butyl, 4-(3-methylphenyl)butyl, 4-(4-methylphenyl)butyl and 4-(2,4-dichlorophenyl)butyl. Halogen or halo is meant to include iodo, fluoro, bromo and chloro moieties. Because of the C=C or C=N double bonds , the novel compounds of the general Formula I may be obtained in preparation as E/Z isomeric mixtures. These isomers can be separated into individual components by conventional means. The cyclopropanes of Formula I may be obtained in preparation as cis and trans isomeric mixtures which can be separated into individual components by conventional means. Both the individual isomeric compounds and mixtures thereof form subjects of the invention and can be used as fungicides and insecticides. The present invention also includes the enantiomorphs, salts and complexes of Formula I. A preferred embodiment of this invention are the compounds, enantiomorphs, salts and complexes of Formula II where A is hydrogen, R 1 and R 2 are hydrogen or (C 1 -C 4 )alkyl, R 3 , R 4 , R 5 and R 6 are hydrogen, R 7 is aryl, aralkyl, or heterocyclic, Z is N-OR 9 where R 9 is (C 1 -C 4 )alkyl, and X and Y are as defined above. A more preferred embodiment of this invention are the compounds, enantiomorphs, salts and complexes of Formula III where (in Formula II) X is N, Y is NH, R 1 , R 2 and R 9 are methyl, A is hydrogen, and R 7 is aryl. Typical compounds encompassed by the present invention of Formula I include those compounds of Formula IV, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=Z=O, and where R 2 , R 3 , and R 7 are defined in Table 1. Compd. R 2 R 3 R 7 1.1 H H Ph 1.2 H H 4-Cl(Ph) 1.3 H H 4-Br(Ph) 1.4 H H 4-F(Ph) 1.5 H H 4-OCH 3 (Ph) 1.6 H H 4-CF 3 (Ph) 1.7 H H 4-NO 2 (Ph) 1.8 H H 2,4-Cl(Ph) 1.9 H H 2,4-F(Ph) 1.10 H H 3,4-F(Ph) 1.11 CH 3 H Ph 1.12 CH 3 H 2-Cl(Ph) 1.13 CH 3 H 3-Cl(Ph) 1.14 CH 3 H 4-Cl(Ph) 1.15 CH 3 H 2-Br(Ph) 1.16 CH 3 H 3-Br(Ph) 1.17 CH 3 H 4-Br(Ph) 1.18 CH 3 H 2-F(Ph) 1.19 CH 3 H 3-F(Ph) 1.20 CH 3 H 4-F(Ph) 1.21 CH 3 H 2-OCH 3 (Ph) 1.22 CH 3 H 3-OCH 3 (Ph) 1.23 CH 3 H 4-OCH 3 (Ph) 1.24 CH 3 H 2-CH 3 (Ph) 1.25 CH 3 H 3-CH 3 (Ph) 1.26 CH 3 H 4-CH 3 (Ph) 1.27 CH 3 H 2-CF 3 (Ph) 1.28 CH 3 H 3-CF 3 (Ph) 1.29 CH 3 H 4-CF 3 (Ph) 1.30 CH 3 H 2-NO 2 (Ph) 1.31 CH 3 H 3-NO 2 (Ph) 1.32 CH 3 H 4-NO 2 (Ph) 1.33 CH 3 H 2,3-Cl(Ph) 1.34 CH 3 H 2,4-Cl(Ph) 1.35 CH 3 H 2,5-Cl(Ph) 1.36 CH 3 H 2,6-Cl(Ph) 1.37 CH 3 H 3,4-Cl(Ph) 1.38 CH 3 H 3,5-Cl(Ph) 1.39 CH 3 H 2,3-F(Ph) 1.40 CH 3 H 2,4-F(Ph) 1.41 CH 3 H 2,5-F(Ph) 1.42 CH 3 H 2,6-F(Ph) 1.43 CH 3 H 3,4-F(Ph) 1.44 CH 3 H 3,5-F(Ph) 1.45 C 2 H 5 H Ph 1.46 C 2 H 5 H 2-Cl(Ph) 1.47 C 2 H 5 H 3-Cl(Ph) 1.48 C 2 H 5 H 4-Cl(Ph) 1.49 C 2 H 5 H 4-Br(Ph) 1.50 C 2 H 5 H 4-F(Ph) 1.51 C 2 H 5 H 4-OCH 3 (Ph) 1.52 C 2 H 5 H 4-CH 3 (Ph) 1.53 C 2 H 5 H 4-NO 2 (Ph) 1.54 C 2 H 5 H 2,4-Cl(Ph) 1.55 C 2 H 5 H 2,4-F(Ph) 1.56 n-C 3 H 7 H Ph 1.57 n-C 3 H 7 H 2-Cl(Ph) 1.58 n-C 3 H 7 H 3-Cl(Ph) 1.59 n-C 3 H 7 H 4-Cl(Ph) 1.60 n-C 3 H 7 H 4-F(Ph) 1.61 n-C 3 H 7 H 3-OCH 3 (Ph) 1.62 n-C 3 H 7 H 4-OCH 3 (Ph) 1.63 n-C 3 H 7 H 4-CH 3 (Ph) 1.64 n-C 3 H 7 H 4-NO 2 (Ph) 1.65 n-C 3 H 7 H 2,4-Cl(Ph) 1.66 n-C 3 H 7 H 2,4-F(Ph) 1.67 iso-C 3 H 7 H Ph 1.68 iso-C 3 H 7 H 2-Cl(Ph) 1.69 iso-C 3 H 7 H 3-Cl(Ph) 1.70 iso-C 3 H 7 H 4-Cl(Ph) 1.71 iso-C 3 H 7 H 4-Br(Ph) 1.72 iso-C 3 H 7 H 4-F(Ph) 1.73 iso-C 3 H 7 H 4-OCH 3 (Ph) 1.74 iso-C 3 H 7 H 4-CH 3 (Ph) 1.75 iso-C 3 H 7 H 4-NO 2 (Ph) 1.76 iso-C 3 H 7 H 2,4-Cl(Ph) 1.77 iso-C 3 H 7 H 2,4-F(Ph) 1.78 n-C 4 H 9 H Ph 1.79 n-C 4 H 9 H 2-Cl(Ph) 1.80 n-C 4 H 9 H 3-Cl(Ph) 1.81 n-C 4 H 9 H 4-Cl(Ph) 1.82 n-C 4 H 9 H 4-Br(Ph) 1.83 n-C 4 H 9 H 4-F(Ph) 1.84 n-C 4 H 9 H 4-OCH 3 (Ph) 1.85 n-C 4 H 9 H 4-CH 3 (Ph) 1.86 n-C 4 H 9 H 4-NO 2 (Ph) 1.87 n-C 4 H 9 H 2,4-Cl(Ph) 1.88 n-C 4 H 9 H 2,4-F(Ph) 1.89 iso-C 4 H 9 H Ph 1.90 iso-C 4 H 9 H 2-Cl(Ph) 1.91 iso-C 4 H 9 H 3-Cl(Ph) 1.92 iso-C 4 H 9 H 4-Cl(Ph) 1.93 iso-C 4 H 9 H 4-F(Ph) 1.94 iso-C 4 H 9 H 3-OCH 3 (Ph) 1.95 iso-C 4 H 9 H 4-OCH 3 (Ph) 1.96 iso-C 4 H 9 H 4-CH 3 (Ph) 1.97 iso-C 4 H 9 H 4-NO 2 (Ph) 1.98 iso-C 4 H 9 H 2,4-Cl(Ph) 1.99 iso-C 4 H 9 H 2,4-F(Ph) 1.100 C(CH 3 ) 3 H Ph 1.101 C(CH 3 ) 3 H 2-Cl(Ph) 1.102 C(CH 3 ) 3 H 3-Cl(Ph) 1.103 C(CH 3 ) 3 H 4-Cl(Ph) 1.104 C(CH 3 ) 3 H 4-F(Ph) 1.105 C(CH 3 ) 3 H 3-OCH 3 (Ph) 1.106 C(CH 3 ) 3 H 4-OCH 3 (Ph) 1.107 C(CH 3 ) 3 H 4-CH 3 (Ph) 1.108 C(CH 3 ) 3 H 4-NO 2 (Ph) 1.109 C(CH 3 ) 3 H 2,4-Cl(Ph) 1.110 C(CH 3 ) 3 H 2,4-F(Ph) 1.111 cyclopropyl H Ph 1.112 cyclopropyl H 2-Cl(Ph) 1.113 cyclopropyl H 3-Cl(Ph) 1.114 cyclopropyl H 4-Cl(Ph) 1.115 cyclopropyl H 4-Br(Ph) 1.116 cyclopropyl H 3-OCH 3 (Ph) 1.117 cyclopropyl H 4-OCH 3 (Ph) 1.118 cyclopropyl H 4-CH 3 (Ph) 1.119 cyclopropyl H 4-NO 2 (Ph) 1.120 cyclopropyl H 2,4-Cl(Ph) 1.121 cyclopropyl H 2,4-F(Ph) 1.122 1-CH 3 -cyclopropyl H Ph 1.123 1-CH 3 -cyclopropyl H 2-Cl(Ph) 1.124 1-CH 3 -cyclopropyl H 3-Cl(Ph) 1.125 1-CH 3 -cyclopropyl H 4-Cl(Ph) 1.126 1-CH 3 -cyclopropyl H 4-Br(Ph) 1.127 1-CH 3 -cyclopropyl H 4-F(Ph) 1.128 1-CH 3 -cyclopropyl H 4-OCH 3 (Ph) 1.129 1-CH 3 -cyclopropyl H 4-CH 3 (Ph) 1.130 1-CH 3 -cyclopropyl H 4-NO 2 (Ph) 1.131 1-CH 3 -cyclopropyl H 2,4-Cl(Ph) 1.132 1-CH 3 -cyclopropyl H 2,4-F(Ph) 1.133 CH 3 CH 3 Ph 1.134 CH 3 CH 3 2-Cl(Ph) 1.135 CH 3 CH 3 3-Cl(Ph) 1.136 CH 3 CH 3 4-Cl(Ph) 1.137 CH 3 CH 3 4-Br(Ph) 1.138 CH 3 CH 3 4-F(Ph) 1.139 CH 3 CH 3 4-OCH 3 (Ph) 1.140 CH 3 CH 3 4-CH 3 (Ph) 1.141 CH 3 CH 3 4-NO 2 (Ph) 1.142 CH 3 CH 3 2,4-Cl(Ph) 1.143 CH 3 CH 3 2,4-F(Ph) 1.144 C 2 H 5 CH 3 Ph 1.145 C 2 H 5 CH 3 2-Cl(Ph) 1.146 C 2 H 5 CH 3 3-Cl(Ph) 1.147 C 2 H 5 CH 3 4-Cl(Ph) 1.148 C 2 H 5 CH 3 4-Br(Ph) 1.149 C 2 H 5 CH 3 4-F(Ph) 1.150 C 2 H 5 CH 3 4-OCH 3 (Ph) 1.151 C 2 H 5 CH 3 4-CH 3 (Ph) 1.152 C 2 H 5 CH 3 4-NO 2 (Ph) 1.153 C 2 H 5 CH 3 2,4-Cl(Ph) 1.154 C 2 H 5 CH 3 2,4-F(Ph) 1.155 n-C 3 H 7 CH 3 Ph 1.156 n-C 3 H 7 CH 3 2-Cl(Ph) 1.157 n-C 3 H 7 CH 3 3-Cl(Ph) 1.158 n-C 3 H 7 CH 3 4-Cl(Ph) 1.159 n-C 3 H 7 CH 3 4-Br(Ph) 1.160 n-C 3 H 7 CH 3 4-F(Ph) 1.161 n-C 3 H 7 CH 3 4-OCH 3 (Ph) 1.162 n-C 3 H 7 CH 3 4-CH 3 (Ph) 1.163 n-C 3 H 7 CH 3 4-NO 2 (Ph) 1.164 n-C 3 H 7 CH 3 2,4-Cl(Ph) 1.165 n-C 3 H 7 CH 3 2,4-F(Ph) 1.166 iso-C 3 H 7 CH 3 Ph 1.167 iso-C 3 H 7 CH 3 2-Cl(Ph) 1.168 iso-C 3 H 7 CH 3 3-Cl(Ph) 1.169 iso-C 3 H 7 CH 3 4-Cl(Ph) 1.170 iso-C 3 H 7 CH 3 4-Br(Ph) 1.171 iso-C 3 H 7 CH 3 4-F(Ph) 1.172 iso-C 3 H 7 CH 3 4-OCH 3 (Ph) 1.173 iso-C 3 H 7 CH 3 4-CH 3 (Ph) 1.174 iso-C 3 H 7 CH 3 4-NO 2 (Ph) 1.175 iso-C 3 H 7 CH 3 2,4-Cl(Ph) 1.176 iso-C 3 H 7 CH 3 2,4-F(Ph) 1.177 n-C 4 H 9 CH 3 Ph 1.178 n-C 4 H 9 CH 3 2-Cl(Ph) 1.179 n-C 4 H 9 CH 3 3-Cl(Ph) 1.180 n-C 4 H 9 CH 3 4-Cl(Ph) 1.181 n-C 4 H 9 CH 3 4-Br(Ph) 1.182 n-C 4 H 9 CH 3 4-F(Ph) 1.183 n-C 4 H 9 CH 3 4-OCH 3 (Ph) 1.184 n-C 4 H 9 CH 3 4-CH 3 (Ph) 1.185 n-C 4 H 9 CH 3 4-NO 2 (Ph) 1.186 n-C 4 H 9 CH 3 2,4-Cl(Ph) 1.187 n-C 4 H 9 CH 3 2,4-F(Ph) 1.188 n-C 4 H 9 CH 3 4-CF 3 (Ph) 1.189 Ph H Ph 1.190 Ph H 2-Cl(Ph) 1.191 Ph H 3-Cl(Ph) 1.192 Ph H 4-Cl(Ph) 1.193 Ph H 4-Br(Ph) 1.194 Ph H 4-F(Ph) 1.195 Ph H 4-OCH 3 (Ph) 1.196 Ph H 4-CH 3 (Ph) 1.197 Ph H 4-NO 2 (Ph) 1.198 Ph H 2,4-Cl(Ph) 1.199 Ph H 2,4-F(Ph) 1.200 Ph CH 3 Ph 1.201 Ph CH 3 2-Cl(Ph) 1.202 Ph CH 3 3-Cl(Ph) 1.203 Ph CH 3 4-Cl(Ph) 1.204 Ph CH 3 4-Br(Ph) 1.205 Ph CH 3 4-F(Ph) 1.206 Ph CH 3 4-OCH 3 (Ph) 1.207 Ph CH 3 4-CH 3 (Ph) 1.208 Ph CH 3 4-NO 2 (Ph) 1.209 Ph CH 3 2,4-Cl(Ph) 1.210 Ph CH 3 2,4-F(Ph) 1.211 CN H Ph 1.212 CN H 2-Cl(Ph) 1.213 CN H 3-Cl(Ph) 1.214 CN H 4-Cl(Ph) 1.215 CN H 4-Br(Ph) 1.216 CN H 4-F(Ph) 1.217 CN H 4-OCH 3 (Ph) 1.218 CN H 4-CH 3 (Ph) 1.219 CN H 4-NO 2 (Ph) 1.220 CN H 2,4-Cl(Ph) 1.221 CN H 2,4-F(Ph) 1.222 CN CH 3 Ph 1.223 CN CH 3 2-Cl(Ph) 1.224 CN CH 3 3-Cl(Ph) 1.225 CN CH 3 4-Cl(Ph) 1.226 CN CH 3 4-Br(Ph) 1.227 CN CH 3 4-F(Ph) 1.228 CN CH 3 4-OCH 3 (Ph) 1.229 CN CH 3 4-CH 3 (Ph) 1.230 CN CH 3 4-NO 2 (Ph) 1.231 CN CH 3 2,4-Cl(Ph) 1.232 CN CH 3 2,4-F(Ph) 1.233 H H 1-napthyl 1.234 CH 3 H 1-napthyl 1.235 C 2 H 5 H 1-napthyl 1.236 n-C 3 H 7 H 1-napthyl 1.237 iso-C 3 H 7 H 1-napthyl 1.238 n-C 4 H 9 H 1-napthyl 1.239 iso-C 4 H 9 H 1-napthyl 1.240 cyclopropyl H 1-napthyl 1.241 1-CH 3 -cyclopropyl H 1-napthyl 1.242 CN H 1-napthyl 1.243 Ph CH 3 1-napthyl 1.244 H CH 3 1-napthyl 1.245 CH 3 CH 3 1-napthyl 1.246 C 2 H 5 CH 3 1-napthyl 1.247 n-C 3 H 7 CH 3 1-napthyl 1.248 iso-C 3 H 7 CH 3 1-napthyl 1.249 n-C 4 H 9 CH 3 1-napthyl 1.250 iso-C 4 H 9 CH 3 1-napthyl 1.251 cyclopropyl CH 3 1-napthyl 1.252 1-CH 3 -cyclopropyl CH 3 1-napthyl 1.253 CN CH 3 1-napthyl 1.254 Ph CH 3 1-napthyl 1.255 H H 2-napthyl 1.256 CH 3 H 2-napthyl 1.257 C 2 H 5 H 2-napthyl 1.258 n-C 3 H 7 H 2-napthyl 1.259 iso-C 3 H 7 H 2-napthyl 1.260 n-C 4 H 9 H 2-napthyl 1.261 iso-C 4 H 9 H 2-napthyl 1.262 cyclopropyl H 2-napthyl 1.263 1-CH 3 -cyclopropyl H 2-napthyl 1.264 CN H 2-napthyl 1.265 Ph H 2-napthyl 1.266 H CH 3 2-napthyl 1.267 CH 3 CH 3 2-napthyl 1.268 C 2 H 5 CH 3 2-napthyl 1.269 n-C 3 H 7 CH 3 2-napthyl 1.270 iso-C 3 H 7 CH 3 2-napthyl 1.271 n-C 4 H 9 CH 3 2-napthyl 1.272 iso-C 4 H 9 CH 3 2-napthyl 1.273 cyclopropyl CH 3 2-napthyl 1.274 1-CH 3 -cyclopropyl CH 3 2-napthyl 1.275 CN CH 3 2-napthyl 1.276 Ph CH 3 2-napthyl 1.277 2-Cl(Ph) CH 3 2-napthyl 1.278 3-Cl(Ph) CH 3 2-napthyl 1.279 4-Cl(Ph) CH 3 2-napthyl 1.280 4-Br(Ph) CH 3 2-napthyl 1.281 4-F(Ph) CH 3 2-napthyl 1.282 4-OCH 3 (Ph) CH 3 2-napthyl 1.283 4-CH 3 (Ph) CH 3 2-napthyl 1.284 3-CF 3 (Ph) CH 3 2-napthyl 1.285 CH 3 C 2 H 5 Ph 1.286 CH 3 C 2 H 5 2-Cl(Ph) 1.287 CH 3 C 2 H 5 3-Cl(Ph) 1.288 CH 3 C 2 H 5 4-Cl(Ph) 1.289 CH 3 C 2 H 5 4-Br(Ph) 1.290 CH 3 C 2 H 5 4-F(Ph) 1.291 CH 3 C 2 H 5 4-OCH 3 (Ph) 1.292 CH 3 C 2 H 5 4-CH 3 (Ph) 1.293 CH 3 C 2 H 5 4-NO 2 (Ph) 1.294 CH 3 C 2 H 5 2,4-Cl(Ph) 1.295 CH 3 C 2 H 5 2,4-F(Ph) 1.296 CH 3 n-C 3 H 7 Ph 1.297 CH 3 n-C 3 H 7 2-Cl(Ph) 1.298 CH 3 n-C 3 H 7 3-Cl(Ph) 1.299 CH 3 n-C 3 H 7 4-Cl(Ph) 1.300 CH 3 n-C 3 H 7 4-Br(Ph) 1.301 CH 3 n-C 3 H 7 4-F(Ph) 1.302 CH 3 n-C 3 H 7 4-OCH 3 (Ph) 1.303 CH 3 n-C 3 H 7 4-CH 3 (Ph) 1.304 CH 3 n-C 3 H 7 4-NO 2 (Ph) 1.305 CH 3 n-C 3 H 7 2,4-Cl(Ph) 1.306 CH 3 n-C 3 H 7 2,4-F(Ph) 1.307 CH 3 iso-C 3 H 7 Ph 1.308 CH 3 iso-C 3 H 7 2-Cl(Ph) 1.309 CH 3 iso-C 3 H 7 3-Cl(Ph) 1.310 CH 3 iso-C 3 H 7 4-Cl(Ph) 1.311 CH 3 iso-C 3 H 7 4-Br(Ph) 1.312 CH 3 iso-C 3 H 7 4-F(Ph) 1.313 CH 3 iso-C 3 H 7 4-OCH 3 (Ph) 1.314 CH 3 iso-C 3 H 7 4-CH 3 (Ph) 1.315 CH 3 iso-C 3 H 7 4-NO 2 (Ph) 1.316 CH 3 iso-C 3 H 7 2,4-Cl(Ph) 1.317 CH 3 iso-C 3 H 7 2,4-F(Ph) 1.318 CH 3 n-C 4 H 9 Ph 1.319 CH 3 n-C 4 H 9 2-Cl(Ph) 1.320 CH 3 n-C 4 H 9 3-Cl(Ph) 1.321 CH 3 n-C 4 H 9 4-Cl(Ph) 1.322 CH 3 n-C 4 H 9 4-Br(Ph) 1.323 CH 3 n-C 4 H 9 4-F(Ph) 1.324 CH 3 n-C 4 H 9 4-OCH 3 (Ph) 1.325 CH 3 n-C 4 H 9 4-CH 3 (Ph) 1.326 CH 3 n-C 4 H 9 4-NO 2 (Ph) 1.327 CH 3 n-C 4 H 9 2,4-Cl(Ph) 1.328 CH 3 n-C 4 H 9 2,4-F(Ph) 1.329 CH 3 cyclopropyl Ph 1.330 CH 3 cyclopropyl 2-Cl(Ph) Typical compounds encompassed by the present invention of Formula I include those compounds of Formula V, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=Z=O, and where R 2 , R 3 , and R 7 are defined in Table 2. Compd. R 2 R 3 R 7 2.1 H H Ph 2.2 H H 4-Cl(Ph) 2.3 H H 4-Br(Ph) 2.4 H H 4-F(Ph) 2.5 H H 4-OCH 3 (Ph) 2.6 H H 4-CF 3 (Ph) 2.7 H H 4-NO 2 (Ph) 2.8 H H 2,4-Cl(Ph) 2.9 H H 2,4-F(Ph) 2.10 H H 3,4-F(Ph) 2.11 CH 3 H Ph 2.12 CH 3 H 2-Cl(Ph) 2.13 CH 3 H 3-Cl(Ph) 2.14 CH 3 H 4-Cl(Ph) 2.15 CH 3 H 2-Br(Ph) 2.16 CH 3 H 3-Br(Ph) 2.17 CH 3 H 4-Br(Ph) 2.18 CH 3 H 2-F(Ph) 2.19 CH 3 H 3-F(Ph) 2.20 CH 3 H 4-F(Ph) 2.21 CH 3 H 2-OCH 3 (Ph) 2.22 CH 3 H 3-OCH 3 (Ph) 2.23 CH 3 H 4-OCH 3 (Ph) 2.24 CH 3 H 2-CH 3 (Ph) 2.25 CH 3 H 3-CH 3 (Ph) 2.26 CH 3 H 4-CH 3 (Ph) 2.27 CH 3 H 2-CF 3 (Ph) 2.28 CH 3 H 3-CF 3 (Ph) 2.29 CH 3 H 4-CF 3 (Ph) 2.30 CH 3 H 2-NO 2 (Ph) 2.31 CH 3 H 3-NO 2 (Ph) 2.32 CH 3 H 4-NO 2 (Ph) 2.33 CH 3 H 2,3-Cl(Ph) 2.34 CH 3 H 2,4-Cl(Ph) 2.35 CH 3 H 2,5-Cl(Ph) 2.36 CH 3 H 2,6-Cl(Ph) 2.37 CH 3 H 3,4-Cl(Ph) 2.38 CH 3 H 3,5-Cl(Ph) 2.39 CH 3 H 2,3-F(Ph) 2.40 CH 3 H 2,4-F(Ph) 2.41 CH 3 H 2,5-F(Ph) 2.42 CH 3 H 2,6-F(Ph) 2.43 CH 3 H 3,4-F(Ph) 2.44 CH 3 H 3,5-FPh) 2.45 C 2 H 5 H Ph 2.46 C 2 H 5 H 2-Cl(Ph) 2.47 C 2 H 5 H 3-Cl(Ph) 2.48 C 2 H 5 H 4-Cl(Ph) 2.49 C 2 H 5 H 4-Br(Ph) 2.50 C 2 H 5 H 4-F(Ph) 2.51 C 2 H 5 H 4-OCH 3 (Ph) 2.52 C 2 H 5 H 4-CH 3 (Ph) 2.53 C 2 H 5 H 4-NO 2 (Ph) 2.54 C 2 H 5 H 2,4-Cl(Ph) 2.55 C 2 H 5 H 2,4-F(Ph) 2.56 n-C 3 H 7 H Ph 2.57 n-C 3 H 7 H 2-Cl(Ph) 2.58 n-C 3 H 7 H 3-Cl(Ph) 2.59 n-C 3 H 7 H 4-Cl(Ph) 2.60 n-C 3 H 7 H 4-F(Ph) 2.61 n-C 3 H 7 H 3-OCH 3 (Ph) 2.62 n-C 3 H 7 H 4-OCH 3 (Ph) 2.63 n-C 3 H 7 H 4-CH 3 (Ph) 2.64 n-C 3 H 7 H 4-NO 2 (Ph) 2.65 n-C 3 H 7 H 2,4-Cl(Ph) 2.66 n-C 3 H 7 H 2,4-F(Ph) 2.67 iso-C 3 H 7 H Ph 2.68 iso-C 3 H 7 H 2-Cl(Ph) 2.69 iso-C 3 H 7 H 3-Cl(Ph) 2.70 iso-C 3 H 7 H 4-Cl(Ph) 2.71 iso-C 3 H 7 H 4-Br(Ph) 2.72 iso-C 3 H 7 H 4-F(Ph) 2.73 iso-C 3 H 7 H 4-OCH 3 (Ph) 2.74 iso-C 3 H 7 H 4-CH 3 (Ph) 2.75 iso-C 3 H 7 H 4-NO 2 (Ph) 2.76 iso-C 3 H 7 H 2,4-Cl(Ph) 2.77 iso-C 3 H 7 H 2,4-F(Ph) 2.78 n-C 4 H 9 H Ph 2.79 n-C 4 H 9 H 2-Cl(Ph) 2.80 n-C 4 H 9 H 3-Cl(Ph) 2.81 n-C 4 H 9 H 4-Cl(Ph) 2.82 n-C 4 H 9 H 4-Br(Ph) 2.83 n-C 4 H 9 H 4-F(Ph) 2.84 n-C 4 H 9 H 4-OCH 3 (Ph) 2.85 n-C 4 H 9 H 4-CH 3 (Ph) 2.86 n-C 4 H 9 H 4-NO 2 (Ph) 2.87 n-C 4 H 9 H 2,4-Cl(Ph) 2.88 n-C 4 H 9 H 2,4-F(Ph) 2.89 iso-C 4 H 9 H Ph 2.90 iso-C 4 H 9 H 2-Cl(Ph) 2.91 iso-C 4 H 9 H 3-Cl(Ph) 2.92 iso-C 4 H 9 H 4-Cl(Ph) 2.93 iso-C 4 H 9 H 4-F(Ph) 2.94 iso-C 4 H 9 H 3-OCH 3 (Ph) 2.95 iso-C 4 H 9 H 4-OCH 3 (Ph) 2.96 iso-C 4 H 9 H 4-CH 3 (Ph) 2.97 iso-C 4 H 9 H 4-NO 2 (Ph) 2.98 iso-C 4 H 9 H 2,4-Cl(Ph) 2.99 iso-C 4 H 9 H 2,4-F(Ph) 2.100 C(CH 3 ) 3 H Ph 2.101 C(CH 3 ) 3 H 2-Cl(Ph) 2.102 C(CH 3 ) 3 H 3-Cl(Ph) 2.103 C(CH 3 ) 3 H 4-Cl(Ph) 2.104 C(CH 3 ) 3 H 4-F(Ph) 2.105 C(CH 3 ) 3 H 3-OCH 3 (Ph) 2.106 C(CH 3 ) 3 H 4-OCH 3 (Ph) 2.107 C(CH 3 ) 3 H 4-CH 3 (Ph) 2.108 C(CH 3 ) 3 H 4-NO 2 (Ph) 2.109 C(CH 3 ) 3 H 2,4-Cl(Ph) 2.110 C(CH 3 ) 3 H 2,4-F(Ph) 2.111 cyclopropyl H Ph 2.112 cyclopropyl H 2-Cl(Ph) 2.113 cyclopropyl H 3-Cl(Ph) 2.114 cyclopropyl H 4-Cl(Ph) 2.115 cyclopropyl H 4-Br(Ph) 2.116 cyclopropyl H 3-OCH 3 (Ph) 2.117 cyclopropyl H 4-OCH 3 (Ph) 2.118 cyclopropyl H 4-CH 3 (Ph) 2.119 cyclopropyl H 4-NO 2 (Ph) 2.120 cyclopropyl H 2,4-Cl(Ph) 2.121 cyclopropyl H 2,4-F(Ph) 2.122 1-CH 3 -cyclopropyl H Ph 2.123 1-CH 3 -cyclopropyl H 2-Cl(Ph) 2.124 1-CH 3 -cyclopropyl H 3-Cl(Ph) 2.125 1-CH 3 -cyclopropyl H 4-Cl(Ph) 2.126 1-CH 3 -cyclopropyl H 4-Br(Ph) 2.127 1-CH 3 -cyclopropyl H 4-F(Ph) 2.128 1-CH 3 -cyclopropyl H 4-OCH 3 (Ph) 2.129 1-CH 3 -cyclopropyl H 4-CH 3 (Ph) 2.130 1-CH 3 -cyclopropyl H 4-NO 2 (Ph) 2.131 1-CH 3 -cyclopropyl H 2,4-Cl(Ph) 2.132 1-CH 3 -cyclopropyl H 2,4-F(Ph) 2.133 CH 3 CH 3 Ph 2.134 CH 3 CH 3 2-Cl(Ph) 2.135 CH 3 CH 3 3-Cl(Ph) 2.136 CH 3 CH 3 4-Cl(Ph) 2.137 CH 3 CH 3 4-Br(Ph) 2.138 CH 3 CH 3 4-F(Ph) 2.139 CH 3 CH 3 4-OCH 3 (Ph) 2.140 CH 3 CH 3 4-CH 3 (Ph) 2.141 CH 3 CH 3 4-NO 2 (Ph) 2.142 CH 3 CH 3 2,4-Cl(Ph) 2.143 CH 3 CH 3 2,4-F(Ph) 2.144 C 2 H 5 CH 3 Ph 2.145 C 2 H 5 CH 3 2-Cl(Ph) 2.146 C 2 H 5 CH 3 3-Cl(Ph) 2.147 C 2 H 5 CH 3 4-Cl(Ph) 2.148 C 2 H 5 CH 3 4-Br(Ph) 2.149 C 2 H 5 CH 3 4-F(Ph) 2.150 C 2 H 5 CH 3 4-OCH 3 (Ph) 2.151 C 2 H 5 CH 3 4-CH 3 (Ph) 2.152 C 2 H 5 CH 3 4-NO 2 (Ph) 2.153 C 2 H 5 CH 3 2,4-Cl(Ph) 2.154 C 2 H 5 CH 3 2,4-F(Ph) 2.155 n-C 3 H 7 CH 3 Ph 2.156 n-C 3 H 7 CH 3 2-Cl(Ph) 2.157 n-C 3 H 7 CH 3 3-Cl(Ph) 2.158 n-C 3 H 7 CH 3 4-Cl(Ph) 2.159 n-C 3 H 7 CH 3 4-Br(Ph) 2.160 n-C 3 H 7 CH 3 4-F(Ph) 2.161 n-C 3 H 7 CH 3 4-OCH 3 (Ph) 2.162 n-C 3 H 7 CH 3 4-CH 3 (Ph) 2.163 n-C 3 H 7 CH 3 4-NO 2 (Ph) 2.164 n-C 3 H 7 CH 3 2,4-Cl(Ph) 2.165 n-C 3 H 7 CH 3 2,4-F(Ph) 2.166 iso-C 3 H 7 CH 3 Ph 2.167 iso-C 3 H 7 CH 3 2-Cl(Ph) 2.168 iso-C 3 H 7 CH 3 3-Cl(Ph) 2.169 iso-C 3 H 7 CH 3 4-Cl(Ph) 2.170 iso-C 3 H 7 CH 3 4-Br(Ph) 2.171 iso-C 3 H 7 CH 3 4-F(Ph) 2.172 iso-C 3 H 7 CH 3 4-OCH 3 (Ph) 2.173 iso-C 3 H 7 CH 3 4-CH 3 (Ph) 2.174 iso-C 3 H 7 CH 3 4-NO 2 (Ph) 2.175 iso-C 3 H 7 CH 3 2,4-Cl(Ph) 2.176 iso-C 3 H 7 CH 3 2,4-F(Ph) 2.177 n-C 4 H 9 CH 3 Ph 2.178 n-C 4 H 9 CH 3 2-Cl(Ph) 2.179 n-C 4 H 9 CH 3 3-Cl(Ph) 2.180 n-C 4 H 9 CH 3 4-Cl(Ph) 2.181 n-C 4 H 9 CH 3 4-Br(Ph) 2.182 n-C 4 H 9 CH 3 4-F(Ph) 2.183 n-C 4 H 9 CH 3 4-OCH 3 (Ph) 2.184 n-C 4 H 9 CH 3 4-CH 3 (Ph) 2.185 n-C 4 H 9 CH 3 4-NO 2 (Ph) 2.186 n-C 4 H 9 CH 3 2,4-Cl(Ph) 2.187 n-C 4 H 9 CH 3 2,4-F(Ph) 2.188 n-C 4 H 9 CH 3 4-CF 3 (Ph) 2.189 Ph H Ph 2.190 Ph H 2-Cl(Ph) 2.191 Ph H 3-Cl(Ph) 2.192 Ph H 4-Cl(Ph) 2.193 Ph H 4-Br(Ph) 2.194 Ph H 4-F(Ph) 2.195 Ph H 4-OCH 3 (Ph) 2.196 Ph H 4-CH 3 (Ph) 2.197 Ph H 4-NO 2 (Ph) 2.198 Ph H 2,4-Cl(Ph) 2.199 Ph H 2,4-F(Ph) 2.200 Ph CH 3 Ph 2.201 Ph CH 3 2-Cl(Ph) 2.202 Ph CH 3 3-Cl(Ph) 2.203 Ph CH 3 4-Cl(Ph) 2.204 Ph CH 3 4-Br(Ph) 2.205 Ph CH 3 4-F(Ph) 2.206 Ph CH 3 4-OCH 3 (Ph) 2.207 Ph CH 3 4-CH 3 (Ph) 2.208 Ph CH 3 4-NO 2 (Ph) 2.209 Ph CH 3 2,4-Cl(Ph) 2.210 Ph CH 3 2,4-F(Ph) 2.211 CN H Ph 2.212 CN H 2-Cl(Ph) 2.213 CN H 3-Cl(Ph) 2.214 CN H 4-Cl(Ph) 2.215 CN H 4-Br(Ph) 2.216 CN H 4-F(Ph) 2.217 CN H 4-OCH 3 (Ph) 2.218 CN H 4-CH 3 (Ph) 2.219 CN H 4-NO 2 (Ph) 2.220 CN H 2,4-Cl(Ph) 2.221 CN H 2,4-F(Ph) 2.222 CN CH 3 Ph 2.223 CN CH 3 2-Cl(Ph) 2.224 CN CH 3 3-Cl(Ph) 2.225 CN CH 3 4-Cl(Ph) 2.226 CN CH 3 4-Br(Ph) 2.227 CN CH 3 4-F(Ph) 2.228 CN CH 3 4-OCH 3 (Ph) 2.229 CN CH 3 4-CH 3 (Ph) 2.230 CN CH 3 4-NO 2 (Ph) 2.231 CN CH 3 2,4-Cl(Ph) 2.232 CN CH 3 2,4-F(Ph) 2.233 H H 1-napthyl 2.234 CH 3 H 1-napthyl 2.235 C 2 H 5 H 1-napthyl 2.236 n-C 3 H 7 H 1-napthyl 2.237 iso-C 3 H 7 H 1-napthyl 2.238 n-C 4 H 9 H 1-napthyl 2.239 iso-C 4 H 9 H 1-napthyl 2.240 cyclopropyl H 1-napthyl 2.241 1-CH 3 -cyclopropyl H 1-napthyl 2.242 CN H 1-napthyl 2.243 Ph H 1-napthyl 2.244 H CH 3 1-napthyl 2.245 CH 3 CH 3 1-napthyl 2.246 C 2 H 5 CH 3 1-napthyl 2.247 n-C 3 H 7 CH 3 1-napthyl 2.248 iso-C 3 H 7 CH 3 1-napthyl 2.249 n-C 4 H 9 CH 3 1-napthyl 2.250 iso-C 4 H 9 CH 3 1-napthyl 2.251 cyclopropyl CH 3 1-napthyl 2.252 1-CH 3 -cyclopropyl CH 3 1-napthyl 2.253 CN CH 3 1-napthyl 2.254 Ph CH 3 1-napthyl 2.255 H H 2-napthyl 2.256 CH 3 H 2-napthyl 2.257 C 2 H 5 H 2-napthyl 2.258 n-C 3 H 7 H 2-napthyl 2.259 iso-C 3 H 7 H 2-napthyl 2.260 n-C 4 H 9 H 2-napthyl 2.261 iso-C 4 H 9 H 2-napthyl 2.262 cyclopropyl H 2-napthyl 2.263 1-CH 3 -cyclopropyl H 2-napthyl 2.264 CN H 2-napthyl 2.265 Ph H 2-napthyl 2.266 H CH 3 2-napthyl 2.267 CH 3 CH 3 2-napthyl 2.268 C 2 H 5 CH 3 2-napthyl 2.269 n-C 3 H 7 CH 3 2-napthyl 2.270 iso-C 3 H 7 CH 3 2-napthyl 2.271 n-C 4 H 9 CH 3 2-napthyl 2.272 iso-C 4 H 9 CH 3 2-napthyl 2.273 cyclopropyl CH 3 2-napthyl 2.274 1-CH 3 -cyclopropyl CH 3 2-napthyl 2.275 CN CH 3 2-napthyl 2.276 Ph CH 3 2-napthyl 2.277 2-Cl(Ph) CH 3 2-napthyl 2.278 3-Cl(Ph) CH 3 2-napthyl 2.279 4-Cl(Ph) CH 3 2-napthyl 2.280 4-Br(Ph) CH 3 2-napthyl 2.281 4-F(Ph) CH 3 2-napthyl 2.282 4-OCH 3 (Ph) CH 3 2-napthyl 2.283 4-CH 3 (Ph) CH 3 2-napthyl 2.284 3-CF 3 (Ph) CH 3 2-napthyl 2.285 CH 3 C 2 H 5 Ph 2.286 CH 3 C 2 H 5 2-Cl(Ph) 2.287 CH 3 C 2 H 5 3-Cl(Ph) 2.288 CH 3 C 2 H 5 4-Cl(Ph) 2.289 CH 3 C 2 H 5 4-Br(Ph) 2.290 CH 3 C 2 H 5 4-F(Ph) 2.291 CH 3 C 2 H 5 4-OCH 3 (Ph) 2.292 CH 3 C 2 H 5 4-CH 3 (Ph) 2.293 CH 3 C 2 H 5 4-NO 2 (Ph) 2.294 CH 3 C 2 H 5 2,4-Cl(Ph) 2.295 CH 3 C 2 H 5 2,4-F(Ph) 2.296 CH 3 n-C 3 H 7 Ph 2.297 CH 3 n-C 3 H 7 2-Cl(Ph) 2.298 CH 3 n-C 3 H 7 3-Cl(Ph) 2.299 CH 3 n-C 3 H 7 4-Cl(Ph) 2.300 CH 3 n-C 3 H 7 4-Br(Ph) 2.301 CH 3 n-C 3 H 7 4-F(Ph) 2.302 CH 3 n-C 3 H 7 4-OCH 3 (Ph) 2.303 CH 3 n-C 3 H 7 4-CH 3 (Ph) 2.304 CH 3 n-C 3 H 7 4-NO 2 (Ph) 2.305 CH 3 n-C 3 H 7 2,4-Cl(Ph) 2.306 CH 3 n-C 3 H 7 2,4-F(Ph) 2.307 CH 3 iso-C 3 H 7 Ph 2.308 CH 3 iso-C 3 H 7 2-Cl(Ph) 2.309 CH 3 iso-C 3 H 7 3-Cl(Ph) 2.310 CH 3 iso-C 3 H 7 4-Cl(Ph) 2.311 CH 3 iso-C 3 H 7 4-Br(Ph) 2.312 CH 3 iso-C 3 H 7 4-F(Ph) 2.313 CH 3 iso-C 3 H 7 4-OCH 3 (Ph) 2.314 CH 3 iso-C 3 H 7 4-CH 3 (Ph) 2.315 CH 3 iso-C 3 H 7 4-NO 2 (Ph) 2.316 CH 3 iso-C 3 H 7 2,4-Cl(Ph) 2.317 CH 3 iso-C 3 H 7 2,4-F(Ph) 2.318 CH 3 n-C 4 H 9 Ph 2.319 CH 3 n-C 4 H 9 2-Cl(Ph) 2.320 CH 3 n-C 4 H 9 3-Cl(Ph) 2.321 CH 3 n-C 4 H 9 4-Cl(Ph) 2.322 CH 3 n-C 4 H 9 4-Br(Ph) 2.323 CH 3 n-C 4 H 9 4-F(Ph) 2.324 CH 3 n-C 4 H 9 4-OCH 3 (Ph) 2.325 CH 3 n-C 4 H 9 4-CH 3 (Ph) 2.326 CH 3 n-C 4 H 9 4-NO 2 (Ph) 2.327 CH 3 n-C 4 H 9 2,4-Cl(Ph) 2.328 CH 3 n-C 4 H 9 2,4-F(Ph) 2.329 CH 3 cyclopropyl Ph 2.330 CH 3 cyclopropyl 2-Cl(Ph) Typical compounds encompassed by the present invention of Formula I include those compounds of Formula VI, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 3. Compd. R 2 R 3 R 7 3.1 H H Ph 3.2 H H 4-Cl(Ph) 3.3 H H 4-Br(Ph) 3.4 H H 4-F(Ph) 3.5 H H 4-OCH 3 (Ph) 3.6 H H 4-CF 3 (Ph) 3.7 H H 4-NO 2 (Ph) 3.8 H H 2,4-Cl(Ph) 3.9 H H 2,4-F(Ph) 3.10 H H 3,4-F(Ph) 3.11 CH 3 H Ph 3.12 CH 3 H 2-Cl(Ph) 3.13 CH 3 H 3-Cl(Ph) 3.14 CH 3 H 4-Cl(Ph) 3.15 CH 3 H 2-Br(Ph) 3.16 CH 3 H 3-Br(Ph) 3.17 CH 3 H 4-Br(Ph) 3.18 CH 3 H 2-F(Ph) 3.19 CH 3 H 3-F(Ph) 3.20 CH 3 H 4-F(Ph) 3.21 CH 3 H 2-OCH 3 (Ph) 3.22 CH 3 H 3-OCH 3 (Ph) 3.23 CH 3 H 4-OCH 3 (Ph) 3.24 CH 3 H 2-CH 3 (Ph) 3.25 CH 3 H 3-CH 3 (Ph) 3.26 CH 3 H 4-CH 3 (Ph) 3.27 CH 3 H 2-CF 3 (Ph) 3.28 CH 3 H 3-CF 3 (Ph) 3.29 CH 3 H 4-CF 3 (Ph) 3.30 CH 3 H 2-NO 2 (Ph) 3.31 CH 3 H 3-NO 2 (Ph) 3.32 CH 3 H 4-NO 2 (Ph) 3.33 CH 3 H 2,3-Cl(Ph) 3.34 CH 3 H 2,4-Cl(Ph) 3.35 CH 3 H 2,5-Cl(Ph) 3.36 CH 3 H 2,6-Cl(Ph) 3.37 CH 3 H 3,4-Cl(Ph) 3.38 CH 3 H 3,5-Cl(Ph) 3.39 CH 3 H 2,3-F(Ph) 3.40 CH 3 H 2,4-F(Ph) 3.41 CH 3 H 2,5-F(Ph) 3.42 CH 3 H 2,6-F(Ph) 3.43 CH 3 H 3,4-F(Ph) 3.44 CH 3 H 3,5-FPh) 3.45 C 2 H 5 H Ph 3.46 C 2 H 5 H 2-Cl(Ph) 3.47 C 2 H 5 H 3-Cl(Ph) 3.48 C 2 H 5 H 4-Cl(Ph) 3.49 C 2 H 5 H 4-Br(Ph) 3.50 C 2 H 5 H 4-F(Ph) 3.51 C 2 H 5 H 4-OCH 3 (Ph) 3.52 C 2 H 5 H 4-CH 3 (Ph) 3.53 C 2 H 5 H 4-NO 2 (Ph) 3.54 C 2 H 5 H 2,4-Cl(Ph) 3.55 C 2 H 5 H 2,4-F(Ph) 3.56 n-C 3 H 7 H Ph 3.57 n-C 3 H 7 H 2-Cl(Ph) 3.58 n-C 3 H 7 H 3-Cl(Ph) 3.59 n-C 3 H 7 H 4-Cl(Ph) 3.60 n-C 3 H 7 H 4-F(Ph) 3.61 n-C 3 H 7 H 3-OCH 3 (Ph) 3.62 n-C 3 H 7 H 4-OCH 3 (Ph) 3.63 n-C 3 H 7 H 4-CH 3 (Ph) 3.64 n-C 3 H 7 H 4-NO 2 (Ph) 3.65 n-C 3 H 7 H 2,4-Cl(Ph) 3.66 n-C 3 H 7 H 2,4-F(Ph) 3.67 iso-C 3 H 7 H Ph 3.68 iso-C 3 H 7 H 2-Cl(Ph) 3.69 iso-C 3 H 7 H 3-Cl(Ph) 3.70 iso-C 3 H 7 H 4-Cl(Ph) 3.71 iso-C 3 H 7 H 4-Br(Ph) 3.72 iso-C 3 H 7 H 4-F(Ph) 3.73 iso-C 3 H 7 H 4-OCH 3 (Ph) 3.74 iso-C 3 H 7 H 4-CH 3 (Ph) 3.75 iso-C 3 H 7 H 4-NO 2 (Ph) 3.76 iso-C 3 H 7 H 2,4-Cl(Ph) 3.77 iso-C 3 H 7 H 2,4-F(Ph) 3.78 n-C 4 H 9 H Ph 3.79 n-C 4 H 9 H 2-Cl(Ph) 3.80 n-C 4 H 9 H 3-Cl(Ph) 3.81 n-C 4 H 9 H 4-Cl(Ph) 3.82 n-C 4 H 9 H 4-Br(Ph) 3.83 n-C 4 H 9 H 4-F(Ph) 3.84 n-C 4 H 9 H 4-OCH 3 (Ph) 3.85 n-C 4 H 9 H 4-CH 3 (Ph) 3.86 n-C 4 H 9 H 4-NO 2 (Ph) 3.87 n-C 4 H 9 H 2,4-Cl(Ph) 3.88 n-C 4 H 9 H 2,4-F(Ph) 3.89 iso-C 4 H 9 H Ph 3.90 iso-C 4 H 9 H 2-Cl(Ph) 3.91 iso-C 4 H 9 H 3-Cl(Ph) 3.92 iso-C 4 H 9 H 4-Cl(Ph) 3.93 iso-C 4 H 9 H 4-F(Ph) 3.94 iso-C 4 H 9 H 3-OCH 3 (Ph) 3.95 iso-C 4 H 9 H 4-OCH 3 (Ph) 3.96 iso-C 4 H 9 H 4-CH 3 (Ph) 3.97 iso-C 4 H 9 H 4-NO 2 (Ph) 3.98 iso-C 4 H 9 H 2,4-Cl(Ph) 3.99 iso-C 4 H 9 H 2,4-F(Ph) 3.100 C(CH 3 ) 3 H Ph 3.101 C(CH 3 ) 3 H 2-Cl(Ph) 3.102 C(CH 3 ) 3 H 3-Cl(Ph) 3.103 C(CH 3 ) 3 H 4-Cl(Ph) 3.104 C(CH 3 ) 3 H 4-F(Ph) 3.105 C(CH 3 ) 3 H 3-OCH 3 (Ph) 3.106 C(CH 3 ) 3 H 4-OCH 3 (Ph) 3.107 C(CH 3 ) 3 H 4-CH 3 (Ph) 3.108 C(CH 3 ) 3 H 4-NO 2 (Ph) 3.109 C(CH 3 ) 3 H 2,4-Cl(Ph) 3.110 C(CH 3 ) 3 H 2,4-F(Ph) 3.111 cyclopropyl H Ph 3.112 cyclopropyl H 2-Cl(Ph) 3.113 cyclopropyl H 3-Cl(Ph) 3.114 cyclopropyl H 4-Cl(Ph) 3.115 cyclopropyl H 4-Br(Ph) 3.116 cyclopropyl H 3-OCH 3 (Ph) 3.117 cyclopropyl H 4-OCH 3 (Ph) 3.118 cyclopropyl H 4-CH 3 (Ph) 3.119 cyclopropyl H 4-NO 2 (Ph) 3.120 cyclopropyl H 2,4-Cl(Ph) 3.121 cyclopropyl H 2,4-F(Ph) 3.122 1-CH 3 -cyclopropyl H Ph 3.123 1-CH 3 -cyclopropyl H 2-Cl(Ph) 3.124 1-CH 3 -cyclopropyl H 3-Cl(Ph) 3.125 1-CH 3 -cyclopropyl H 4-Cl(Ph), 3.126 1-CH 3 -cyclopropyl H 4-Br(Ph) 3.127 1-CH 3 -cyclopropyl H 4-F(Ph) 3.128 1-CH 3 -cyclopropyl H 4-OCH 3 (Ph) 3.129 1-CH 3 -cyclopropyl H 4-CH 3 (Ph) 3.130 1-CH 3 -cyclopropyl H 4-NO 2 (Ph) 3.131 1-CH 3 -cyclopropyl H 2,4-Cl(Ph) 3.132 1-CH 3 -cyclopropyl H 2,4-F(Ph) 3.133 CH 3 CH 3 Ph 3.134 CH 3 CH 3 2-Cl(Ph) 3.135 CH 3 CH 3 3-Cl(Ph) 3.136 CH 3 CH 3 4-Cl(Ph) 3.137 CH 3 CH 3 4-Br(Ph) 3.138 CH 3 CH 3 4-F(Ph) 3.139 CH 3 CH 3 4-OCH 3 (Ph) 3.140 CH 3 CH 3 4-CH 3 (Ph) 3.141 CH 3 CH 3 4-NO 2 (Ph) 3.142 CH 3 CH 3 2,4-Cl(Ph) 3.143 CH 3 CH 3 2,4-F(Ph) 3.144 C 2 H 5 CH 3 Ph 3.145 C 2 H 5 CH 3 2-Cl(Ph) 3.146 C 2 H 5 CH 3 3-Cl(Ph) 3.147 C 2 H 5 CH 3 4-Cl(Ph) 3.148 C 2 H 5 CH 3 4-Br(Ph) 3.149 C 2 H 5 CH 3 4-F(Ph) 3.150 C 2 H 5 CH 3 4-OCH 3 (Ph) 3.151 C 2 H 5 CH 3 4-CH 3 (Ph) 3.152 C 2 H 5 CH 3 4-NO 2 (Ph) 3.153 C 2 H 5 CH 3 2,4-Cl(Ph) 3.154 C 2 H 5 CH 3 2,4-F(Ph) 3.155 n-C 3 H 7 CH 3 Ph 3.156 n-C 3 H 7 CH 3 2-Cl(Ph) 3.157 n-C 3 H 7 CH 3 3-Cl(Ph) 3.158 n-C 3 H 7 CH 3 4-Cl(Ph) 3.159 n-C 3 H 7 CH 3 4-Br(Ph) 3.160 n-C 3 H 7 CH 3 4-F(Ph) 3.161 n-C 3 H 7 CH 3 4-OCH 3 (Ph) 3.162 n-C 3 H 7 CH 3 4-CH 3 (Ph) 3.163 n-C 3 H 7 CH 3 4-NO 2 (Ph) 3.164 n-C 3 H 7 CH 3 2,4-Cl(Ph) 3.165 n-C 3 H 7 CH 3 2,4-F(Ph) 3.166 iso-C 3 H 7 CH 3 Ph 3.167 iso-C 3 H 7 CH 3 2-Cl(Ph) 3.168 iso-C 3 H 7 CH 3 3-Cl(Ph) 3.169 iso-C 3 H 7 CH 3 4-Cl(Ph) 3.170 iso-C 3 H 7 CH 3 4-Br(Ph) 3.171 iso-C 3 H 7 CH 3 4-F(Ph) 3.172 iso-C 3 H 7 CH 3 4-OCH 3 (Ph) 3.173 iso-C 3 H 7 CH 3 4-CH 3 (Ph) 3.174 iso-C 3 H 7 CH 3 4-NO 2 (Ph) 3.175 iso-C 3 H 7 CH 3 2,4-Cl(Ph) 3.176 iso-C 3 H 7 CH 3 2,4-F(Ph) 3.177 n-C 4 H 9 CH 3 Ph 3.178 n-C 4 H 9 CH 3 2-Cl(Ph) 3.179 n-C 4 H 9 CH 3 3-Cl(Ph) 3.180 n-C 4 H 9 CH 3 4-Cl(Ph) 3.181 n-C 4 H 9 CH 3 4-Br(Ph) 3.182 n-C 4 H 9 CH 3 4-F(Ph) 3.183 n-C 4 H 9 CH 3 4-OCH 3 (Ph) 3.184 n-C 4 H 9 CH 3 4-CH 3 (Ph) 3.185 n-C 4 H 9 CH 3 4-NO 2 (Ph) 3.186 n-C 4 H 9 CH 3 2,4-Cl(Ph) 3.187 n-C 4 H 9 CH 3 2,4-F(Ph) 3.188 n-C 4 H 9 CH 3 4-CF 3 (Ph) 3.189 Ph H Ph 3.190 Ph H 2-Cl(Ph) 3.191 Ph H 3-Cl(Ph) 3.192 Ph H 4-Cl(Ph) 3.193 Ph H 4-Br(Ph) 3.194 Ph H 4-F(Ph) 3.195 Ph H 4-OCH 3 (Ph) 3.196 Ph H 4-CH 3 (Ph) 3.197 Ph H 4-NO 2 (Ph) 3.198 Ph H 2,4-Cl(Ph) 3.199 Ph H 2,4-F(Ph) 3.200 Ph CH 3 Ph 3.201 Ph CH 3 2-Cl(Ph) 3.202 Ph CH 3 3-Cl(Ph) 3.203 Ph CH 3 4-Cl(Ph) 3.204 Ph CH 3 4-Br(Ph) 3.205 Ph CH 3 4-F(Ph) 3.206 Ph CH 3 4-OCH 3 (Ph) 3.207 Ph CH 3 4-CH 3 (Ph) 3.208 Ph CH 3 4-NO 2 (Ph) 3.209 Ph CH 3 2,4-Cl(Ph) 3.210 Ph CH 3 2,4-F(Ph) 3.211 CN H Ph 3.212 CN H 2-Cl(Ph) 3.213 CN H 3-Cl(Ph) 3.214 CN H 4-Cl(Ph) 3.215 CN H 4-Br(Ph) 3.216 CN H 4-F(Ph) 3.217 CN H 4-OCH 3 (Ph) 3.218 CN H 4-CH 3 (Ph) 3.219 CN H 4-NO 2 (Ph) 3.220 CN H 2,4-Cl(Ph) 3.221 CN H 2,4-F(Ph) 3.222 CN CH 3 Ph 3.223 CN CH 3 2-Cl(Ph) 3.224 CN CH 3 3-Cl(Ph) 3.225 CN CH 3 4-Cl(Ph) 3.226 CN CH 3 4-Br(Ph) 3.227 CN CH 3 4-F(Ph) 3.228 CN CH 3 4-OCH 3 (Ph) 3.229 CN CH 3 4-CH 3 (Ph) 3.230 CN CH 3 4-NO 2 (Ph) 3.231 CN CH 3 2,4-Cl(Ph) 3.232 CN CH 3 2,4-F(Ph) 3.233 H H 1-napthyl 3.234 CH 3 H 1-napthyl 3.235 C 2 H 5 H 1-napthyl 3.236 n-C 3 H 7 H 1-napthyl 3.237 iso-C 3 H 7 H 1-napthyl 3.238 n-C 4 H 9 H 1-napthyl 3.239 iso-C 4 H 9 H 1-napthyl 3.240 cyclopropyl H 1-napthyl 3.241 1-CH 3 -cyclopropyl H 1-napthyl 3.242 CN H 1-napthyl 3.243 Ph H 1-napthyl 3.244 H CH 3 1-napthyl 3.245 CH 3 CH 3 1-napthyl 3.246 C 2 H 5 CH 3 1-napthyl 3.247 n-C 3 H 7 CH 3 1-napthyl 3.248 iso-C 3 H 7 CH 3 1-napthyl 3.249 n-C 4 H 9 CH 3 1-napthyl 3.250 iso-C 4 H 9 CH 3 1-napthyl 3.251 cyclopropyl CH 3 1-napthyl 3.252 1-CH 3 -cyclopropyl CH 3 1-napthyl 3.253 CN CH 3 1-napthyl 3.254 Ph CH 3 1-napthyl 3.255 H H 2-napthyl 3.256 CH 3 H 2-napthyl 3.257 C 2 H 5 H 2-napthyl 3.258 n-C 3 H 7 H 2-napthyl 3.259 iso-C 3 H 7 H 2-napthyl 3.260 n-C 4 H 9 H 2-napthyl 3.261 iso-C 4 H 9 H 2-napthyl 3.262 cyclopropyl H 2-napthyl 3.263 1-CH 3 -cyclopropyl H 2-napthyl 3.264 CN H 2-napthyl 3.265 Ph H 2-napthyl 3.266 H CH 3 2-napthyl 3.267 CH 3 CH 3 2-napthyl 3.268 C 2 H 5 CH 3 2-napthyl 3.269 n-C 3 H 7 CH 3 2-napthyl 3.270 iso-C 3 H 7 CH 3 2-napthyl 3.271 n-C 4 H 9 CH 3 2-napthyl 3.272 iso-C 4 H 9 CH 3 2-napthyl 3.273 cyclopropyl CH 3 2-napthyl 3.274 1-CH 3 -cyclopropyl CH 3 2-napthyl 3.275 CN CH 3 2-napthyl 3.276 Ph CH 3 2-napthyl 3.277 2-Cl(Ph) CH 3 2-napthyl 3.278 3-Cl(Ph) CH 3 2-napthyl 3.279 4-Cl(Ph) CH 3 2-napthyl 3.280 4-Br(Ph) CH 3 2-napthyl 3.281 4-OCH 3 (Ph) CH 3 2-napthyl 3.282 4-CH 3 (Ph) CH 3 2-napthyl 3.283 3-CF 3 (Ph) CH 3 2-napthyl 3.284 CH 3 C 2 H 5 Ph 3.285 CH 3 C 2 H 5 2-Cl(Ph) 3.286 CH 3 C 2 H 5 3-Cl(Ph) 3.287 CH 3 C 2 H 5 4-Cl(Ph) 3.288 CH 3 C 2 H 5 4-Br(Ph) 3.289 CH 3 C 2 H 5 4-F(Ph) 3.290 CH 3 C 2 H 5 4-OCH 3 (Ph) 3.291 CH 3 C 2 H 5 4-CH 3 (Ph) 3.292 CH 3 C 2 H 5 4-NO 2 (Ph) 3.293 CH 3 C 2 H 5 2,4-Cl(Ph) 3.294 CH 3 C 2 H 5 2,4-F(Ph) 3.295 CH 3 n-C 3 H 7 Ph 3.296 CH 3 n-C 3 H 7 2-Cl(Ph) 3.297 CH 3 n-C 3 H 7 3-Cl(Ph) 3.298 CH 3 n-C 3 H 7 4-Cl(Ph) 3.299 CH 3 n-C 3 H 7 4-Br(Ph) 3.300 CH 3 n-C 3 H 7 4-F(Ph) 3.301 CH 3 n-C 3 H 7 4-OCH 3 (Ph) 3.302 CH 3 n-C 3 H 7 4-CH 3 (Ph) 3.303 CH 3 n-C 3 H 7 4-NO 2 (Ph) 3.304 CH 3 n-C 3 H 7 2,4-Cl(Ph) 3.305 CH 3 n-C 3 H 7 2,4-F(Ph) 3.306 CH 3 iso-C 3 H 7 Ph 3.307 CH 3 iso-C 3 H 7 2-Cl(Ph) 3.308 CH 3 iso-C 3 H 7 3-Cl(Ph) 3.309 CH 3 iso-C 3 H 7 4-Cl(Ph) 3.310 CH 3 iso-C 3 H 7 4-Br(Ph) 3.311 CH 3 iso-C 3 H 7 4-F(Ph) 3.312 CH 3 iso-C 3 H 7 4-OCH 3 (Ph) 3.313 CH 3 iso-C 3 H 7 4-CH 3 (Ph) 3.314 CH 3 iso-C 3 H 7 4-NO 2 (Ph) 3.315 CH 3 iso-C 3 H 7 2,4-Cl(Ph) 3.316 CH 3 iso-C 3 H 7 2,4-F(Ph) 3.317 CH 3 n-C 4 H 9 Ph 3.318 CH 3 n-C 4 H 9 2-Cl(Ph) 3.319 CH 3 n-C 4 H 9 3-Cl(Ph) 3.320 CH 3 n-C 4 H 9 4-Cl(Ph) 3.321 CH 3 n-C 4 H 9 4-Br(Ph) 3.322 CH 3 n-C 4 H 9 4-F(Ph) 3.323 CH 3 n-C 4 H 9 4-OCH 3 (Ph) 3.324 CH 3 n-C 4 H 9 4-CH 3 (Ph) 3.325 CH 3 n-C 4 H 9 4-NO 2 (Ph) 3.326 CH 3 n-C 4 H 9 2,4-Cl(Ph) 3.327 CH 3 n-C 4 H 9 2,4-F(Ph) Typical compounds encompassed by the present invention of Formula I include those compounds of Formula IV, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 4. Compd. R 2 R 3 R 7 4.1 H Ph Ph 4.2 H Ph 2-Cl(Ph) 4.3 H Ph 3-Cl(Ph) 4.4 H Ph 4-Cl(Ph) 4.5 H Ph 2-Br(Ph) 4.6 H Ph 3-Br(Ph) 4.7 H Ph 4-Br(Ph) 4.8 H Ph 2-F(Ph) 4.9 H Ph 3-F(Ph) 4.10 H Ph 4-F(Ph) 4.11 H Ph 2-OCH 3 (Ph) 4.12 H Ph 3-OCH 3 (Ph) 4.13 H Ph 4-OCH 3 (Ph) 4.14 H Ph 2-OC 2 H 5 (Ph) 4.15 H Ph 3-OC 2 H 5 (Ph) 4.16 H Ph 4-OC 2 H 5 (Ph) 4.17 H Ph 4-OPh(Ph) 4.18 H Ph 2-CH 3 (Ph) 4.19 H Ph 3-CH 3 Ph) 4.20 H Ph 4-CH 3 (Ph) 4.21 H Ph 2-CF 3 (Ph) 4.22 H Ph 3-CF 3 (Ph) 4.23 H Ph 4-CF 3 (Ph) 4.24 H Ph 2-NO 2 (Ph) 4.25 H Ph 3-NO 2 (Ph) 4.26 H Ph 4-NO 2 (Ph) 4.27 H Ph 2,3-Cl(Ph) 4.28 H Ph 2,4-Cl(Ph) 4.29 H Ph 2,5-Cl(Ph) 4.30 H Ph 2,6-Cl(Ph) 4.31 H Ph 3,4-Cl(Ph) 4.32 H Ph 3,5-Cl(Ph) 4.33 H Ph 2,3-F(Ph) 4.34 H Ph 2,4-F(Ph) 4.35 H Ph 2,5-F(Ph) 4.36 H Ph 2,6-F(Ph) 4.37 H Ph 3,4-F(Ph) 4.38 H Ph 3,5-F(Ph) 4.39 CH 3 Ph Ph 4.40 CH 3 Ph 2-Cl(Ph) 4.41 CH 3 Ph 3-Cl(Ph) 4.42 CH 3 Ph 4-Cl(Ph) 4.43 CH 3 Ph 2-Br(Ph) 4.44 CH 3 Ph 3-Br(Ph) 4.45 CH 3 Ph 4-Br(Ph) 4.46 CH 3 Ph 2-F(Ph) 4.47 CH 3 Ph 3-F(Ph) 4.48 CH 3 Ph 4-F(Ph) 4.49 CH 3 Ph 2-OCH 3 (Ph) 4.50 CH 3 Ph 3-OCH 3 (Ph) 4.51 CH 3 Ph 4-OCH 3 (Ph) 4.52 CH 3 Ph 2-OC 2 H 5 (Ph) 4.53 CH 3 Ph 3-OC 2 H 5 (Ph) 4.54 CH 3 Ph 4-OC 2 H 5 (Ph) 4.55 CH 3 Ph 2-OPh(Ph) 4.56 CH 3 Ph 3-OPh(Ph) 4.57 CH 3 Ph 4-OPh(Ph) 4.58 CH 3 Ph 2-CH 3 (Ph) 4.59 CH 3 Ph 3-CH 3 Ph) 4.60 CH 3 Ph 4-CH 3 (Ph) 4.61 CH 3 Ph 2-CF 3 (Ph) 4.62 CH 3 Ph 3-CF 3 (Ph) 4.63 CH 3 Ph 4-CF 3 (Ph) 4.64 CH 3 Ph 4-OCF 3 (Ph) 4.65 CH 3 Ph 2-NO 2 (Ph) 4.66 CH 3 Ph 3-NO 2 (Ph) 4.67 CH 3 Ph 4-NO 2 (Ph) 4.68 CH 3 Ph 2,3-Cl(Ph) 4.69 CH 3 Ph 2,4-Cl(Ph) 4.70 CH 3 Ph 2,5-Cl(Ph) 4.71 CH 3 Ph 2,6-Cl(Ph) 4.72 CH 3 Ph 3,4-Cl(Ph) 4.73 CH 3 Ph 3,5-Cl(Ph) 4.74 CH 3 Ph 2,3-F(Ph) 4.75 CH 3 Ph 2,4-F(Ph) 4.76 CH 3 Ph 2,5-F(Ph) 4.77 CH 3 Ph 2,6-F(Ph) 4.78 CH 3 Ph 3,4-F(Ph) 4.79 CH 3 Ph 3,5-FPh) 4.80 C 2 H 5 Ph 2-Cl(Ph) 4.81 n-C 3 H 7 Ph 3-Cl(Ph) 4.82 iso-C 3 H 7 Ph 4-Cl(Ph) 4.83 n-C 4 H 9 Ph 4-Br(Ph) 4.84 iso-C 4 H 9 Ph 4-F(Ph) 4.85 C(CH 3 ) 3 Ph 4-OCH 3 (Ph) 4.86 n-C 5 H 11 Ph 4-CH 3 (Ph) 4.87 cyclopropyl Ph 4-NO 2 (Ph) 4.88 1-CH 3 -cyclopropyl Ph 2,4-Cl(Ph) 4.89 CN Ph 2,4-F(Ph) 4.90 Ph Ph Ph 4.91 Ph Ph 2-Cl(Ph) 4.92 Ph Ph 3-Cl(Ph) 4.93 Ph Ph 4-Cl(Ph) 4.94 4-Cl(Ph) Ph Ph 4.95 4-Cl(Ph) Ph 4-Cl(Ph) 4.96 4-F(Ph) Ph Ph 4.97 4-F(Ph) Ph 4-F(Ph) 4.98 4-CF 3 (Ph) Ph Ph 4.99 4-CF 3 (Ph) Ph 4-CF 3 (Ph) 4.100 2,4-Cl(Ph) Ph Ph 4.101 2,4-Cl(Ph) Ph 2,4-Cl(Ph) 4.102 2,4-F(Ph) Ph Ph 4.103 H 2-Cl(Ph) Ph 4.104 CH 3 2-Cl(Ph) Ph 4.105 C 2 H 5 2-Cl(Ph) 2-Cl(Ph) 4.106 n-C 3 H 7 2-Cl(Ph) 3-Cl(Ph) 4.107 iso-C 3 H 7 2-Cl(Ph) 4-Cl(Ph) 4.108 n-C 4 H 9 2-Cl(Ph) 4-Br(Ph) 4.109 iso-C 4 H 9 2-Cl(Ph) 4-F(Ph) 4.110 C(CH 3 ) 3 2-Cl(Ph) 4-OCH 3 (Ph) 4.111 n-C 5 H 11 2-Cl(Ph) 4-CH 3 (Ph) 4.112 cyclopropyl 2-Cl(Ph) 4-NO 2 (Ph) 4.113 1-CH 3 -cyclopropyl 2-Cl(Ph) 2,4-Cl(Ph) 4.114 CN 2-Cl(Ph) 2,4-F(Ph) 4.115 Ph 2-Cl(Ph) 2-Cl(Ph) 4.116 Ph 2-Cl(Ph) 3-Cl(Ph) 4.117 Ph 2-Cl(Ph) 4-Cl(Ph) 4.118 4-Cl(Ph) 2-Cl(Ph) Ph 4.119 4-Cl(Ph) 2-Cl(Ph) 4-Cl(Ph) 4.120 4-F(Ph) 2-Cl(Ph) Ph 4.121 4-F(Ph) 2-Cl(Ph) 4-F(Ph) 4.122 4-CF 3 (Ph) 2-Cl(Ph) Ph 4.123 4-CF 3 (Ph) 2-Cl(Ph) 4-CF 3 (Ph) 4.124 2,4-Cl(Ph) 2-Cl(Ph) Ph 4.125 2,4-Cl(Ph) 2-Cl(Ph) 2,4-Cl(Ph) 4.126 2,4-F(Ph) 2-Cl(Ph) Ph 4.127 H 4-Cl(Ph) Ph 4.128 CH 3 4-Cl(Ph) Ph 4.129 C 2 H 5 4-Cl(Ph) 2-Cl(Ph) 4.130 n-C 3 H 7 4-Cl(Ph) 3-Cl(Ph) 4.131 iso-C 3 H 7 4-Cl(Ph) 4-Cl(Ph) 4.132 n-C 4 H 9 4-Cl(Ph) 4-Br(Ph) 4.133 iso-C 4 H 9 4-Cl(Ph) 4-F(Ph) 4.134 C(CH 3 ) 3 4-Cl(Ph) 4-OCH 3 (Ph) 4.135 n-C 5 H 11 4-Cl(Ph) 4-CH 3 (Ph) 4.136 cyclopropyl 4-Cl(Ph) 4-NO 2 (Ph) 4.137 1-CH 3 -cyclopropyl 4-Cl(Ph) 2,4-Cl(Ph) 4.138 CN 4-Cl(Ph) 2,4-F(Ph) 4.139 Ph 4-Cl(Ph) 2-Cl(Ph) 4.140 Ph 4-Cl(Ph) 3-Cl(Ph) 4.141 Ph 4-Cl(Ph) 4-Cl(Ph) 4.142 4-Cl(Ph) 4-Cl(Ph) Ph 4.143 4-Cl(Ph) 4-Cl(Ph) 4-Cl(Ph) 4.144 4-F(Ph) 4-Cl(Ph) Ph 4.145 4-F(Ph) 4-Cl(Ph) 4-F(Ph) 4.146 4-CF 3 (Ph) 4-Cl(Ph) Ph 4.147 4-CF 3 (Ph) 4-Cl(Ph) 4-CF 3 (Ph) 4.148 2,4-Cl(Ph) 4-Cl(Ph) Ph 4.149 2,4-Cl(Ph) 4-Cl(Ph) 2,4-Cl(Ph) 4.150 2,4-F(Ph) 4-Cl(Ph) Ph 4.151 H 4-CF 3 (Ph) Ph 4.152 CH 3 4-CF 3 (Ph) Ph 4.153 C 2 H 5 4-CF 3 (Ph) 2-Cl(Ph) 4.154 n-C 3 H 7 4-CF 3 (Ph) 3-Cl(Ph) 4.155 iso-C 3 H 7 4-CF 3 (Ph) 4-Cl(Ph) 4.156 n-C 4 H 9 4-CF 3 (Ph) 4-Br(Ph) 4.157 iso-C 4 H 9 4-CF 3 (Ph) 4-F(Ph) 4.158 C(CH3)3 4-CF 3 (Ph) 4-OCH 3 (Ph) 4.159 n-C 5 H 11 4-CF 3 (Ph) 4-CH 3 (Ph) 4.160 cyclopropyl 4-CF 3 (Ph) 4-NO 2 (Ph) 4.161 1-CH 3 -cyclopropyl 4-CF 3 (Ph) 2,4-Cl(Ph) 4.162 CN 4-CF 3 (Ph) 2,4-F(Ph) 4.163 Ph 4-CF 3 (Ph) 2-Cl(Ph) 4.164 Ph 4-CF 3 (Ph) 3-Cl(Ph) 4.165 Ph 4-CF 3 (Ph) 4-Cl(Ph) 4.166 4-Cl(Ph) 4-CF 3 (Ph) Ph 4.167 4-Cl(Ph) 4-CF 3 (Ph) 4-Cl(Ph) 4.168 4-F(Ph) 4-CF 3 (Ph) Ph 4.169 4-F(Ph) 4-CF 3 (Ph) 4-F(Ph) 4.170 4-CF 3 (Ph) 4-CF 3 (Ph) Ph 4.171 4-CF 3 (Ph) 4-CF 3 (Ph) 4-CF 3 (Ph) 4.172 2,4-Cl(Ph) 4-CF 3 (Ph) Ph 4.173 2,4-Cl(Ph) 4-CF 3 (Ph) 2,4-Cl(Ph) 4.174 2,4-F(Ph) 4-CF 3 (Ph) Ph 4.175 H 1-napthyl Ph 4.176 CH 3 1-napthyl Ph 4.177 C 2 H 5 1-napthyl 2-Cl(Ph) 4.178 n-C 3 H 7 1-napthyl 3-Cl(Ph) 4.179 iso-C 3 H 7 1-napthyl 4-Cl(Ph) 4.180 n-C 4 H 9 1-napthyl 4-Br(Ph) 4.181 iso-C 4 H 9 1-napthyl 4-F(Ph) 4.182 C(CH 3 ) 3 1-napthyl 4-OCH 3 (Ph) 4.183 n-C 5 H 11 1-napthyl 4-CH 3 (Ph) 4.184 cyclopropyl 1-napthyl 4-NO 2 (Ph) 4.185 1-CH 3 -cyclopropyl 1-napthyl 2,4-Cl(Ph) 4.186 CN 1-napthyl 2,4-F(Ph) 4.187 Ph 1-napthyl 2-Cl(Ph) 4.188 Ph 1-napthyl 3-Cl(Ph) 4.189 Ph 1-napthyl 4-Cl(Ph) 4.190 4-Cl(Ph) 1-napthyl Ph 4.191 4-Cl(Ph) 1-napthyl 4-Cl(Ph) 4.192 4-F(Ph) 1-napthyl Ph 4.193 4-F(Ph) 1-napthyl 4-F(Ph) 4.194 4-CF 3 (Ph) 1-napthyl Ph 4.195 4-CF 3 (Ph) 1-napthyl 4-CF 3 (Ph) 4.196 2,4-Cl(Ph) 1-napthyl Ph 4.197 2,4-Cl(Ph) 1-napthyl 2,4-Cl(Ph) 4.198 2,4-F(Ph) 1-napthyl Ph 4.199 CH 3 2-pyridyl Ph 4.200 CH 3 3-pyridyl Ph 4.201 CH 3 4-pyridyl Ph 4.202 CH 3 2-thienyl Ph 4.203 CH 3 3-thienyl Ph 4.204 CH 3 2-furyl Ph 4.205 CH 3 3-furyl Ph 4.206 CH 3 5-pyrimidinyl Ph 4.207 CH 3 2-pyridyl 4-Cl(Ph) 4.208 CH 3 3-pyridyl 4-Cl(Ph) 4.209 CH 3 4-pyridyl 4-Cl(Ph) 4.210 CH 3 2-thienyl 4-Cl(Ph) 4.211 CH 3 3-thienyl 4-Cl(Ph) 4.212 CH 3 2-furyl 4-Cl(Ph) 4.213 CH 3 3-furyl 4-Cl(Ph) 4.214 CH 3 5-pyrimidinyl 4-Cl(Ph) 4.215 CH 3 2-pyridyl 3-CF 3 (Ph) 4.216 CH 3 3-pyridyl 3-CF 3 (Ph) 4.217 CH 3 4-pyridyl 3-CF 3 (Ph) 4.218 CH 3 2-thienyl 3-CF 3 (Ph) 4.219 CH 3 3-thienyl 3-CF 3 (Ph) 4.220 CH 3 2-furyl 3-CF 3 (Ph) 4.221 CH 3 3-furyl 3-CF 3 (Ph) 4.222 CH 3 5-pyrimidinyl 3-CF 3 (Ph) 4.223 CH 3 2-pyridyl 4-CF 3 (Ph) 4.224 CH 3 3-pyridyl 4-CF 3 (Ph) 4.225 CH 3 4-pyridyl 4-CF 3 (Ph) 4.226 CH 3 2-thienyl 4-CF 3 (Ph) Table 5: Compounds 5.1 to 5.226 are compounds of Formula V, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 4. Table 6: Compounds 6.1 to 6.226 are compounds of Formula VI, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 4. Typical compounds encompassed by the present invention of Formula I include those compounds of Formula IV, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 7. Compd. R 2 R 3 R 7 7.1 H H 2-pyridyl 7.2 H H 3-pyridyl 7.3 H H 4-pyridyl 7.4 H H 2-thienyl 7.5 H H 3-thienyl 7.6 H H 2-furyl 7.7 H H 3-furyl 7.8 H H 4-pyrimidinyl 7.9 H H 5-pyrimidinyl 7.10 H H pyrazinyl 7.11 CH 3 H 2-pyridyl 7.12 CH 3 H 3-pyridyl 7.13 CH 3 H 4-pyridyl 7.14 CH 3 H 2-thienyl 7.15 CH 3 H 3-thienyl 7.16 CH 3 H 2-furyl 7.17 CH 3 H 3-furyl 7.18 CH 3 H 4-pyrimidinyl 7.19 CH 3 H 5-pyrimidinyl 7.20 CH 3 H pyrazinyl 7.21 C 2 H 5 H 2-pyridyl 7.22 C 2 H 5 H 3-pyridyl 7.23 C 2 H 5 H 4-pyridyl 7.24 C 2 H 5 H 2-thienyl 7.25 C 2 H 5 H 3-thienyl 7.26 C 2 H 5 H 2-furyl 7.27 C 2 H 5 H 3-furyl 7.28 C 2 H 5 H 4-pyrimidinyl 7.29 C 2 H 5 H 5-pyrimidinyl 7.30 C 2 H 5 H pyrazinyl 7.31 n-C 3 H 7 H 2-pyridyl 7.32 n-C 3 H 7 H 3-pyridyl 7.33 n-C 3 H 7 H 4-pyridyl 7.34 n-C 3 H 7 H 2-thienyl 7.35 n-C 3 H 7 H 3-thienyl 7.36 n-C 3 H 7 H 2-furyl 7.37 n-C 3 H 7 H 3-furyl 7.38 n-C 3 H 7 H 4-pyrimidinyl 7.39 n-C 3 H 7 H 5-pyrimidinyl 7.40 n-C 3 H 7 H pyrazinyl 7.41 cyclopropyl H 2-pyridyl 7.42 cyclopropyl H 3-pyridyl 7.43 cyclopropyl H 4-pyridyl 7.44 cyclopropyl H 2-thienyl 7.45 cyclopropyl H 3-thienyl 7.46 cyclopropyl H 2-furyl 7.47 cyclopropyl H 3-furyl 7.48 cyclopropyl H 4-pyrimidinyl 7.49 cyclopropyl H 5-pyrimidinyl 7.50 cyclopropyl H pyrazinyl 7.51 CN H 2-pyridyl 7.52 CN H 3-pyridyl 7.53 CN H 4-pyridyl 7.54 CN H 2-thienyl 7.55 CN H 3-thienyl 7.56 CN H 2-furyl 7.57 CN H 3-furyl 7.58 CN H 4-pyrimidinyl 7.59 CN H 5-pyrimidinyl 7.60 CN H pyrazinyl 7.61 CH 3 CH 3 2-pyridyl 7.62 CH 3 CH 3 3-pyridyl 7.63 CH 3 CH 3 4-pyridyl 7.64 CH 3 CH 3 2-thienyl 7.65 CH 3 CH 3 3-thienyl 7.66 CH 3 CH 3 2-furyl 7.67 CH 3 CH 3 3-furyl 7.68 CH 3 CH 3 4-pyrimidinyl 7.69 CH 3 CH 3 5-pyrimidinyl 7.70 CH 3 CH 3 pyrazinyl 7.71 CH 3 H 2-pyridylCH 2 - 7.71 CH 3 H 3-pyridylCH 2 - 7.70 CH 3 H 4-pyridylCH 2 - 7.71 CH 3 H 2-thienylCH 2 - 7.72 CH 3 H 3-thienyllCH 2 - 7.73 CH 3 H 2-furylCH 2 - 7.74 CH 3 H 3-furylCH 2 - 7.75 CH 3 CH 3 2-pyridylCH 2 - 7.76 CH 3 CH 3 2-thienylCH 2 - 7.77 H Ph 2-pyridyl 7.78 H Ph 3-pyridyl 7.79 H Ph 4-pyridyl 7.80 H Ph 2-thienyl 7.81 H Ph 3-thienyl 7.82 H Ph 2-furyl 7.83 H Ph 3-furyl 7.84 H Ph 4-pyrimidinyl 7.85 H Ph 5-pyrimidinyl 7.86 H Ph pyrazinyl 7.87 CH 3 Ph 2-pyridyl 7.88 CH 3 Ph 3-pyridyl 7.89 CH 3 Ph 4-pyridyl 7.90 CH 3 Ph 2-thienyl 7.91 CH 3 Ph 3-thienyl 7.92 CH 3 Ph 2-furyl 7.93 CH 3 Ph 3-furyl 7.94 CH 3 Ph 4-pyrimidinyl 7.95 CH 3 Ph 5-pyrimidinyl 7.96 CH 3 Ph pyrazinyl 7.97 CH 3 2-Cl(Ph) 2-pyridyl 7.98 CH 3 2-Cl(Ph) 3-pyridyl 7.99 CH 3 2-Cl(Ph) 4-pyridyl 7.100 CH 3 2-Cl(Ph) 2-thienyl 7.101 CH 3 2-Cl(Ph) 3-thienyl 7.102 CH 3 2-Cl(Ph) 2-furyl 7.103 CH 3 2-Cl(Ph) 3-furyl 7.104 CH 3 2-Cl(Ph) 4-pyrimidinyl 7.105 CH 3 2-Cl(Ph) 5-pyrimidinyl 7.106 CH 3 2-Cl(Ph) pyrazinyl 7.107 CH 3 4-Cl(Ph) 2-pyridyl 7.108 CH 3 4-Cl(Ph) 3-pyridyl 7.109 CH 3 4-Cl(Ph) 4-pyridyl 7.110 CH 3 4-Cl(Ph) 2-thienyl 7.111 CH 3 4-Cl(Ph) 3-thienyl 7.112 CH 3 4-Cl(Ph) 2-furyl 7.113 CH 3 4-Cl(Ph) 3-furyl 7.114 CH 3 4-Cl(Ph) 4-pyrimidinyl 7.115 CH 3 4-Cl(Ph) 5-pyrimidinyl 7.116 CH 3 4-Cl(Ph) pyrazinyl 7.117 CH 3 1-napthyl 2-pyridyl 7.118 CH 3 1-napthyl 3-pyridyl 7.119 CH 3 1-napthyl 4-pyridyl 7.120 CH 3 1-napthyl 2-thienyl 7.121 CH 3 1-napthyl 3-thienyl 7.122 CH 3 1-napthyl 2-furyl 7.123 CH 3 1-napthyl 3-furyl 7.124 CH 3 1-napthyl 4-pyrimidinyl 7.125 CH 3 1-napthyl 5-pyrimidinyl 7.126 CH 3 1-napthyl pyrazinyl 7.127 CN Ph 2-pyridyl 7.128 CN Ph 3-pyridyl 7.129 CN Ph 4-pyridyl 7.130 CN Ph 2-thienyl 7.131 CN Ph 3-thienyl 7.132 CN Ph 2-furyl 7.133 CN Ph 3-furyl 7.134 CN Ph 4-pyrimidinyl 7.135 CN Ph 5-pyrimidinyl 7.136 CN Ph pyrazinyl 7.127 CN 4-Cl(Ph) 2-pyridyl 7.128 CN 4-Cl(Ph) 3-pyridyl 7.129 CN 4-Cl(Ph) 4-pyridyl 7.130 CN 4-Cl(Ph) 2-thienyl 7.131 CN 4-Cl(Ph) 3-thienyl 7.132 CN 4-Cl(Ph) 2-furyl 7.133 CN 4-Cl(Ph) 3-furyl 7.134 CN 4-Cl(Ph) 4-pyrimidinyl 7.135 CN 4-Cl(Ph) 5-pyrimidinyl 7.136 CN 4-Cl(Ph) pyrazinyl 7.127 CN 1-napthyl 2-pyridyl 7.128 CN 1-napthyl 3-pyridyl 7.129 CN 1-napthyl 4-pyridyl 7.130 CN 1-napthyl 2-thienyl 7.131 CN 1-napthyl 3-thienyl 7.132 CN 1-napthyl 2-furyl 7.133 CN 1-napthyl 3-furyl 7.134 CN 1-napthyl 4-pyrimidinyl 7.135 CN 1-napthyl 5-pyrimidinyl 7.136 CN 1-napthyl pyrazinyl 7.137 H 2-pyridyl 2-pyridyl 7.138 H 3-pyridyl 2-pyridyl 7.139 H 4-pyridyl 2-pyridyl 7.140 H 2-thienyl 2-pyridyl 7.141 H 3-thienyl 2-pyridyl 7.142 H 2-furyl 2-pyridyl 7.143 H 3-furyl 2-pyridyl 7.144 H 4-pyrimidinyl 2-pyridyl 7.145 H 5-pyrimidinyl 2-pyridyl 7.146 H pyrazinyl 2-pyridyl 7.147 H 2-pyridyl 3-pyridyl 7.148 H 3-pyridyl 3-pyridyl 7.149 H 4-pyridyl 3-pyridyl 7.150 H 2-thienyl 3-pyridyl 7.151 H 3-thienyl 3-pyridyl 7.152 H 2-furyl 3-pyridyl 7.153 H 3-furyl 3-pyridyl 7.154 H 4-pyrimidinyl 3-pyridyl 7.155 H 5-pyrimidinyl 3-pyridyl 7.156 H pyrazinyl 3-pyridyl 7.157 H 2-pyridyl 2-thienyl 7.158 H 3-pyridyl 2-thienyl 7.159 H 4-pyridyl 2-thienyl 7.160 H 2-thienyl 2-thienyl 7.161 H 3-thienyl 2-thienyl 7.162 H 2-furyl 2-thienyl 7.163 H 3-furyl 2-thienyl 7.164 H 4-pyrimidinyl 2-thienyl 7.165 H 5-pyrimidinyl 2-thienyl 7.166 H pyrazinyl 2-thienyl 7.167 CH 3 2-pyridyl 2-pyridyl 7.168 CH 3 3-pyridyl 2-pyridyl 7.169 CH 3 4-pyridyl 2-pyridyl 7.170 CH 3 2-thienyl 2-pyridyl 7.171 CH 3 3-thienyl 2-pyridyl 7.172 CH 3 2-furyl 2-pyridyl 7.173 CH 3 3-furyl 2-pyridyl 7.174 CH 3 4-pyrimidinyl 2-pyridyl 7.175 CH 3 5-pyrimidinyl 2-pyridyl 7.176 CH 3 pyrazinyl 2-pyridyl 7.177 CH 3 2-pyridyl 3-pyridyl 7.178 CH 3 3-pyridyl 3-pyridyl 7.179 CH 3 4-pyridyl 3-pyridyl 7.180 CH 3 2-thienyl 3-pyridyl 7.181 CH 3 3-thienyl 3-pyridyl 7.182 CH 3 2-furyl 3-pyridyl 7.183 CH 3 3-furyl 3-pyridyl 7.184 CH 3 4-pyrimidinyl 3-pyridyl 7.185 CH 3 5-pyrimidinyl 3-pyridyl 7.186 CH 3 pyrazinyl 3-pyridyl 7.187 CH 3 2-pyridyl 2-thienyl 7.188 CH 3 3-pyridyl 2-thienyl 7.190 CH 3 4-pyridyl 2-thienyl 7.191 CH 3 2-thienyl 2-thienyl 7.192 CH 3 3-thienyl 2-thienyl 7.193 CH 3 2-furyl 2-thienyl 7.194 CH 3 3-furyl 2-thienyl 7.195 CH 3 4-pyrimidinyl 2-thienyl 7.196 CH 3 5-pyrimidinyl 2-thienyl 7.197 CH 3 pyrazinyl 2-thienyl 7.198 CN 2-pyridyl 2-pyridyl 7.199 CN 3-pyridyl 2-pyridyl 7.200 CN 4-pyridyl 2-pyridyl 7.201 CN 2-thienyl 2-pyridyl 7.202 CN 3-thienyl 2-pyridyl 7.203 CN 2-furyl 2-pyridyl 7.204 CN 3-furyl 2-pyridyl 7.205 CN 4-pyrimidinyl 2-pyridyl 7.206 CN 5-pyrimidinyl 2-pyridyl 7.207 CN pyrazinyl 2-pyridyl 7.208 CN 2-pyridyl 3-pyridyl 7.209 CN 3-pyridyl 3-pyridyl 7.210 CN 4-pyridyl 3-pyridyl 7.211 CN 2-thienyl 3-pyridyl 7.212 CN 3-thienyl 3-pyridyl 7.213 CN 2-furyl 3-pyridyl 7.214 CN 3-furyl 3-pyridyl 7.215 CN 4-pyrimidinyl 3-pyridyl 7.216 CN 5-pyrimidinyl 3-pyridyl 7.217 CN pyrazinyl 3-pyridyl 7.218 CN 2-pyridyl 2-thienyl 7.219 CN 3-pyridyl 2-thienyl 7.220 CN 4-pyridyl 2-thienyl 7.221 CN 2-thienyl 2-thienyl Table 8: Compounds 8.1 to 8.221 are compounds of Formula V, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 7. Table 9:Compounds 9.1 to 9.221 are compounds of Formula V, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, N-H, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 7. Typical compounds encompassed by the present invention of Formula I include those compounds of Formula IV, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 10. Compd. R 2 R 3 R 7 10.1 H Ph H 10.2 H Ph CH 3 10.3 H Ph C 2 H 5 10.4 H Ph n-C 3 H 7 10.5 H Ph iso-C 3 H 7 10.6 H Ph n-C 4 H 9 10.7 H Ph C(CH 3 ) 3 10.8 H Ph n-C 5 H 11 10.9 H Ph cyclopropyl 10.10 H 4-Cl(Ph) H 10.11 H 4-Cl(Ph) CH 3 10.12 H 4-Cl(Ph) C 2 H 5 10.13 H 4-Cl(Ph) n-C 3 H 7 10.14 H 4-Cl(Ph) iso-C 3 H 7 10.15 H 4-Cl(Ph) n-C 4 H 9 10.16 H 4-Cl(Ph) C(CH 3 ) 3 10.17 H 4-Cl(Ph) n-C 5 H 11 10.18 H 4-Cl(Ph) cyclopropyl 10.19 H 4-Cl(Ph) cyclohexyl 10.20 CH 3 Ph H 10.21 CH 3 Ph CH 3 10.22 CH 3 Ph C 2 H 5 10.23 CH 3 Ph n-C 3 H 7 10.24 CH 3 Ph iso-C 3 H 7 10.25 CH 3 Ph n-C 4 H 9 10.26 CH 3 Ph C(CH 3 ) 3 10.27 CH 3 Ph n-C 5 H 11 10.28 CH 3 Ph cyclopropyl 10.29 CH 3 4-Cl(Ph) H 10.30 CH 3 4-Cl(Ph) CH 3 10.31 CH 3 4-Cl(Ph) C 2 H 5 10.32 CH 3 4-Cl(Ph) n-C 3 H 7 10.33 CH 3 4-Cl(Ph) iso-C 3 H 7 10.34 CH 3 4-Cl(Ph) n-C 4 H 9 10.35 CH 3 4-Cl(Ph) C(CH 3 ) 3 10.36 CH 3 4-Cl(Ph) n-C 5 H 11 10.37 CH 3 4-Cl(Ph) cyclopropyl 10.38 CH 3 4-Cl(Ph) cyclohexyl 10.39 H 1-napthyl H 10.40 H 1-napthyl CH 3 10.41 H 1-napthyl C 2 H 5 10.42 H 1-napthyl n-C 3 H 7 10.43 H 1-napthyl iso-C 3 H 7 10.44 H 1-napthyl n-C 4 H 9 10.45 H 1-napthyl C(CH 3 ) 3 10.46 H 1-napthyl n-C 5 H 11 10.47 H 1-napthyl cyclopropyl 10.48 H 1-napthyl cyclohexyl 10.49 CH 3 1-napthyl H 10.50 CH 3 1-napthyl CH 3 10.51 CH 3 1-napthyl C 2 H 5 10.52 CH 3 1-napthyl n-C 3 H 7 10.53 CH 3 1-napthyl iso-C 3 H 7 10.54 CH 3 1-napthyl n-C 4 H 9 10.55 CH 3 1-napthyl C(CH 3 ) 3 10.56 CH 3 1-napthyl n-C 5 H 11 10.57 CH 3 1-napthyl cyclopropyl 10.58 CH 3 1-napthyl cyclohexyl 10.59 H 2-pyridyl H 10.60 H 2-pyridyl CH 3 10.61 H 2-pyridyl C 2 H 5 10.62 H 2-pyridyl n-C 3 H 7 10.63 H 2-pyridyl iso-C 3 H 7 10.64 H 2-pyridyl n-C 4 H 9 10.65 H 2-pyridyl C(CH 3 ) 3 10.66 H 2-pyridyl n-C 5 H 11 10.67 H 2-pyridyl cyclopropyl 10.68 H 2-pyridyl cyclohexyl 10.69 H 3-pyridyl H 10.70 H 3-pyridyl CH 3 10.71 H 3-pyridyl C 2 H 5 10.72 H 3-pyridyl n-C 3 H 7 10.73 H 3-pyridyl n-C 4 H 9 10.74 H 3-pyridyl iso-C 4 H 9 10.75 H 3-pyridyl C(CH 3 ) 3 10.76 H 3-pyridyl n-C 5 H 11 10.77 H 3-pyridyl cyclopropyl 10.78 H 3-pyridyl cyclohexyl 10.79 H 2-thienyl H 10.80 H 2-thienyl CH 3 10.81 H 2-thienyl C 2 H 5 10.82 H 2-thienyl n-C 3 H 7 10.83 H 2-thienyl iso-C 3 H 7 10.84 H 2-thienyl n-C 4 H 9 10.85 H 2-thienyl C(CH 3 ) 3 10.86 H 2-thienyl n-C 5 H 11 10.87 H 2-thienyl cyclopropyl 10.88 H 2-thienyl cyclohexyl 10.89 H 3-thienyl H 10.90 H 3-thienyl CH 3 10.91 H 3-thienyl C 2 H 5 10.92 H 3-thienyl n-C 3 H 7 10.93 H 3-thienyl iso-C 3 H 7 10.94 H 3-thienyl n-C 4 H 9 10.95 H 3-thienyl C(CH 3 ) 3 10.96 H 3-thienyl n-C 5 H 11 10.97 H 3-thienyl cyclopropyl 10.98 H 3-thienyl cyclohexyl 10.99 H 2-furyl H 10.90 H 2-furyl CH 3 10.91 H 2-furyl C 2 H 5 10.92 H 2-furyl n-C 3 H 7 10.93 H 2-furyl iso-C 3 H 7 10.94 H 2-furyl n-C 4 H 9 10.95 H 2-furyl C(CH 3 ) 3 10.96 H 2-furyl n-C 5 H 11 10.97 H 2-furyl cyclopropyl 10.98 H 2-furyl cyclohexyl 10.99 CH 3 2-pyridyl H 10.100 CH 3 2-pyridyl CH 3 10.102 CH 3 2-pyridyl C 2 H 5 10.103 CH 3 2-pyridyl n-C 3 H 7 10.104 CH 3 2-pyridyl iso-C 3 H 7 10.105 CH 3 2-pyridyl n-C 4 H 9 10.106 CH 3 2-pyridyl C(CH 3 ) 3 10.107 CH 3 2-pyridyl n-C 5 H 11 10.108 CH 3 2-pyridyl cyclopropyl 10.109 CH 3 2-pyridyl cyclohexyl 10.110 CH 3 3-pyridyl H 10.111 CH 3 3-pyridyl CH 3 10.112 CH 3 3-pyridyl C 2 H 5 10.113 CH 3 3-pyridyl n-C 3 H 7 10.114 CH 3 3-pyridyl iso-C 3 H 7 10.115 CH 3 3-pyridyl n-C 4 H 9 10.116 CH 3 3-pyridyl C(CH 3 ) 3 10.117 CH 3 3-pyridyl n-C 5 H 11 10.118 CH 3 3-pyridyl cyclopropyl 10.119 CH 3 3-pyridyl cyclohexyl 10.120 CH 3 2-thienyl H 10.121 CH 3 2-thienyl CH 3 10.122 CH 3 2-thienyl C 2 H 5 10.123 CH 3 2-thienyl n-C 3 H 7 10.124 CH 3 2-thienyl iso-C 3 H 7 10.125 CH 3 2-thienyl n-C 4 H 9 10.126 CH 3 2-thienyl C(CH 3 ) 3 10.127 CH 3 2-thienyl n-C 5 H 11 10.128 CH 3 2-thienyl cyclopropyl 10.129 CH 3 2-thienyl cyclohexyl 10.130 CH 3 3-thienyl H 10.131 CH 3 3-thienyl CH 3 10.132 CH 3 3-thienyl C 2 H 5 10.133 CH 3 3-thienyl n-C 3 H 7 10.134 CH 3 3-thienyl iso-C 3 H 7 10.135 CH 3 3-thienyl n-C 4 H 9 10.136 CH 3 3-thienyl C(CH 3 ) 3 10.137 CH 3 3-thienyl n-C 5 H 11 10.138 CH 3 3-thienyl cyclopropyl 10.139 CH 3 3-thienyl cyclohexyl Table 11: Compounds 11.1 to 11.139 are compounds of Formula V, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 10. Table 12: Compounds 12.1 to 12.139 are compounds of Formula VI, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=O, and where R 2 , R 3 , and R 7 are defined in Table 10. Typical compounds encompassed by the present invention of Formula I include those compounds of Formula VII, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NOR 9 , and where R 2 , R 3 , R 7 and R 9 are defined in Table 13. Compd R 2 R 3 R 7 R 9 13.1 H H Ph H 13.2 H H 4-Cl(Ph) H 13.3 H H 4-Br(Ph) H 13.4 H H 4-F(Ph) H 13.5 H H 4-OCH 3 (Ph) H 13.6 H H 4-CF 3 (Ph) H 13.7 H H Ph CH 3 13.8 H H 4-Cl(Ph) CH 3 13.9 H H 4-Br(Ph) CH 3 13.10 H H 4-F(Ph) CH 3 13.11 CH 3 H Ph H 13.12 CH 3 H 2-Cl(Ph) H 13.13 CH 3 H 3-Cl(Ph) H 13.14 CH 3 H 4-Cl(Ph) H 13.15 CH 3 H 2-Br(Ph) H 13.16 CH 3 H 3-Br(Ph) H 13.17 CH 3 H 4-Br(Ph) H 13.18 CH 3 H Ph CH 3 13.19 CH 3 H 2-Cl(Ph) CH 3 13.20 CH 3 H 3-Cl(Ph) CH 3 13.21 CH 3 H 4-Cl(Ph) CH 3 13.22 CH 3 H 2-F(Ph) CH 3 13.23 CH 3 H 3-F(Ph) CH 3 13.24 CH 3 H 4-F(Ph) CH 3 13.25 CH 3 H 2-CH 3 (Ph) CH 3 13.26 CH 3 H 3-CH 3 (Ph) CH 3 13.27 CH 3 H 2-CF 3 (Ph) CH 3 13.28 CH 3 H 3-CF 3 (Ph) CH 3 13.29 CH 3 H 4-CF 3 (Ph) CH 3 13.30 CH 3 H 2-OCH 3 (Ph) CH 3 13.31 CH 3 H 3-OCH 3 (Ph) CH 3 13.32 CH 3 H 2-OCH 3 (Ph) CH 3 13.33 CH 3 H 2,3-Cl(Ph) CH 3 13.34 CH 3 H 2,4-Cl(Ph) CH 3 13.35 CH 3 H 2,5-Cl(Ph) CH 3 13.36 CH 3 H 2,6-Cl(Ph) CH 3 13.37 CH 3 H 3,4-Cl(Ph) CH 3 13.38 CH 3 H 3,5-Cl(Ph) CH 3 13.39 CH 3 H Ph C 2 H 5 13.40 CH 3 H Ph n-C 3 H 7 13.41 CH 3 H Ph iso-C 3 H 7 13.42 CH 3 H Ph n-C 4 H 9 13.43 CH 3 H Ph C(CH3) 3 13.44 CH 3 H Ph CH 2 C≡CH 13.45 C 2 H 5 H Ph CH 3 13.46 C 2 H 5 H 2-Cl(Ph) CH 3 13.47 C 2 H 5 H 3-Cl(Ph) CH 3 13.48 C 2 H 5 H 4-Cl(Ph) CH 3 13.49 C 2 H 5 H 4-Br(Ph) CH 3 13.50 C 2 H 5 H 4-F(Ph) CH 3 13.51 C 2 H 5 H 4-OCH 3 (Ph) CH 3 13.52 C 2 H 5 H 4-CH 3 (Ph) CH 3 13.53 C 2 H 5 H 4-NO 2 (Ph) CH 3 13.54 C 2 H 5 H 2,4-Cl(Ph) CH 3 13.55 C 2 H 5 H 2,4-F(Ph) CH 3 13.56 n-C 3 H 7 H Ph CH 3 13.57 n-C 3 H 7 H 2-Cl(Ph) CH 3 13.58 n-C 3 H 7 H 3-Cl(Ph) CH 3 13.59 n-C 3 H 7 H 4-Cl(Ph) CH 3 13.60 n-C 3 H 7 H 4-F(Ph) CH 3 13.61 n-C 3 H 7 H 3-OCH 3 (Ph) CH 3 13.62 n-C 3 H 7 H 4-OCH 3 (Ph) CH 3 13.63 n-C 3 H 7 H 4-CH 3 (Ph) CH 3 13.64 n-C 3 H 7 H 4-NO 2 (Ph) CH 3 13.65 n-C 3 H 7 H 2,4-Cl(Ph) CH 3 13.66 n-C 3 H 7 H 2,4-F(Ph) CH 3 13.67 iso-C 3 H 7 H Ph CH 3 13.68 iso-C 3 H 7 H 2-Cl(Ph) CH 3 13.69 iso-C 3 H 7 H 3-Cl(Ph) CH 3 13.70 iso-C 3 H 7 H 4-Cl(Ph) CH 3 13.71 iso-C 3 H 7 H 4-Br(Ph) CH 3 13.72 iso-C 3 H 7 H 4-F(Ph) CH 3 13.73 iso-C 3 H 7 H 4-OCH 3 (Ph) CH 3 13.74 iso-C 3 H 7 H 4-CH 3 (Ph) CH 3 13.75 iso-C 3 H 7 H 4-NO 2 (Ph) CH 3 13.76 iso-C 3 H 7 H 2,4-Cl(Ph) CH 3 13.77 iso-C 3 H 7 H 2,4-F(Ph) CH 3 13.78 n-C 4 H 9 H Ph CH 3 13.79 n-C 4 H 9 H 2-Cl(Ph) CH 3 13.80 n-C 4 H 9 H 3-Cl(Ph) CH 3 13.81 n-C 4 H 9 H 4-Cl(Ph) CH 3 13.82 n-C 4 H 9 H 4-Br(Ph) CH 3 13.83 n-C 4 H 9 H 4-F(Ph) CH 3 13.84 n-C 4 H 9 H 4-OCH 3 (Ph) CH 3 13.85 n-C 4 H 9 H 4-CH 3 (Ph) CH 3 13.86 n-C 4 H 9 H 4-NO 2 (Ph) CH 3 13.87 n-C 4 H 9 H 2,4-Cl(Ph) CH 3 13.88 n-C 4 H 9 H 2,4-F(Ph) CH 3 13.89 iso-C 4 H 9 H Ph CH 3 13.90 iso-C 4 H 9 H 2-Cl(Ph) CH 3 13.91 iso-C 4 H 9 H 3-Cl(Ph) CH 3 13.92 iso-C 4 H 9 H 4-Cl(Ph) CH 3 13.93 iso-C 4 H 9 H 4-F(Ph) CH 3 13.94 iso-C 4 H 9 H 3-OCH 3 (Ph) CH 3 13.95 iso-C 4 H 9 H 4-OCH 3 (Ph) CH 3 13.96 iso-C 4 H 9 H 4-CH 3 (Ph) CH 3 13.97 iso-C 4 H 9 H 4-NO 2 (Ph) CH 3 13.98 iso-C 4 H 9 H 2,4-Cl(Ph) CH 3 13.99 iso-C 4 H 9 H 2,4-F(Ph) CH 3 13.100 C(CH 3 ) 3 H Ph CH 3 13.101 C(CH 3 ) 3 H 2-Cl(Ph) CH 3 13.102 C(CH 3 ) 3 H 3-Cl(Ph) CH 3 13.103 C(CH 3 ) 3 H 4-Cl(Ph) CH 3 13.104 C(CH 3 ) 3 H 4-F(Ph) CH 3 13.105 C(CH 3 ) 3 H 3-OCH 3 (Ph) CH 3 13.106 C(CH 3 ) 3 H 4-OCH 3 (Ph) CH 3 13.107 C(CH 3 ) 3 H 4-CH 3 (Ph) CH 3 13.108 C(CH 3 ) 3 H 4-NO 2 (Ph) CH 3 13.109 C(CH 3 ) 3 H 2,4-Cl(Ph) CH 3 13.110 C(CH 3 ) 3 H 2,4-F(Ph) CH 3 13.111 cyclopropyl H Ph CH 3 13.112 cyclopropyl H 2-Cl(Ph) CH 3 13.113 cyclopropyl H 3-Cl(Ph) CH 3 13.114 cyclopropyl H 4-Cl(Ph) CH 3 13.115 cyclopropyl H 4-Br(Ph) CH 3 13.116 cyclopropyl H 3-OCH 3 (Ph) CH 3 13.117 cyclopropyl H 4-OCH 3 (Ph) CH 3 13.118 cyclopropyl H 4-CH 3 (Ph) CH 3 13.119 cyclopropyl H 4-NO 2 (Ph) CH 3 13.120 cyclopropyl H 2,4-Cl(Ph) CH 3 13.121 cyclopropyl H 2,4-F(Ph) CH 3 13.122 1-CH 3 -cyclopropyl H Ph CH 3 13.123 1-CH 3 -cyclopropyl H 2-Cl(Ph) CH 3 13.124 1-CH 3 -cyclopropyl H 3-Cl(Ph) CH 3 13.125 1-CH 3 -cyclopropyl H 4-Cl(Ph) CH 3 13.126 1-CH 3 -cyclopropyl H 4-Br(Ph) CH 3 13.127 1-CH 3 -cyclopropyl H 4-F(Ph) CH 3 13.128 1-CH 3 -cyclopropyl H 4-OCH 3 (Ph) CH 3 13.129 1-CH 3 -cyclopropyl H 4-CH 3 (Ph) CH 3 13.130 1-CH 3 -cyclopropyl H 4-NO 2 (Ph) CH 3 13.131 1-CH 3 -cyclopropyl H 2,4-Cl(Ph) CH 3 13.132 1-CH 3 -cyclopropyl H 2,4-F(Ph) CH 3 13.133 CH 3 CH 3 Ph H 13.134 CH 3 CH 3 Ph CH 3 13.135 CH 3 CH 3 Ph C 2 H 5 13.136 CH 3 CH 3 Ph n-C 3 H 7 13.137 CH 3 CH 3 Ph iso-C 3 H 7 13.138 CH 3 CH 3 Ph n-C 4 H 9 13.139 CH 3 CH 3 Ph iso-C 4 H 9 13.140 CH 3 CH 3 Ph C(CH 3 ) 3 13.141 CH 3 CH 3 Ph CH 2 C≡CH 13.142 CH 3 CH 3 2-Cl(Ph) CH 3 13.143 CH 3 CH 3 3-Cl(Ph) CH 3 13.144 C 2 H 5 CH 3 Ph CH 3 13.145 C 2 H 5 CH 3 2-Cl(Ph) CH 3 13.146 C 2 H 5 CH 3 3-Cl(Ph) CH 3 13.147 C 2 H 5 CH 3 4-Cl(Ph) CH 3 13.148 C 2 H 5 CH 3 4-Br(Ph) CH 3 13.149 C 2 H 5 CH 3 4-F(Ph) CH 3 13.150 C 2 H 5 CH 3 4-OCH 3 (Ph) CH 3 13.151 C 2 H 5 CH 3 4-CH 3 (Ph) CH 3 13.152 C 2 H 5 CH 3 4-NO 2 (Ph) CH 3 13.153 C 2 H 5 CH 3 2,4-Cl(Ph) CH 3 13.154 C 2 H 5 CH 3 2,4-F(Ph) CH 3 13.155 n-C 3 H 7 CH 3 Ph CH 3 13.156 n-C 3 H 7 CH 3 2-Cl(Ph) CH 3 13.157 n-C 3 H 7 CH 3 3-Cl(Ph) CH 3 13.158 n-C 3 H 7 CH 3 4-Cl(Ph) CH 3 13.159 n-C 3 H 7 CH 3 4-Br(Ph) CH 3 13.160 n-C 3 H 7 CH 3 4-F(Ph) CH 3 13.161 n-C 3 H 7 CH 3 4-OCH 3 (Ph) CH 3 13.162 n-C 3 H 7 CH 3 4-CH 3 (Ph) CH 3 13.163 n-C 3 H 7 CH 3 4-NO 2 (Ph) CH 3 13.164 n-C 3 H 7 CH 3 2,4-Cl(Ph) CH 3 13.165 n-C 3 H 7 CH 3 2,4-F(Ph) CH 3 13.166 iso-C 3 H 7 CH 3 Ph CH 3 13.167 iso-C 3 H 7 CH 3 2-Cl(Ph) CH 3 13.168 iso-C 3 H 7 CH 3 3-Cl(Ph) CH 3 13.169 iso-C 3 H 7 CH 3 4-Cl(Ph) CH 3 13.170 iso-C 3 H 7 CH 3 4-Br(Ph) CH 3 13.171 iso-C 3 H 7 CH 3 4-F(Ph) CH 3 13.172 iso-C 3 H 7 CH 3 4-OCH 3 (Ph) CH 3 13.173 iso-C 3 H 7 CH 3 4-CH 3 (Ph) CH 3 13.174 iso-C 3 H 7 CH 3 4-NO 2 (Ph) CH 3 13.175 iso-C 3 H 7 CH 3 2,4-Cl(Ph) CH 3 13.176 iso-C 3 H 7 CH 3 2,4-F(Ph) CH 3 13.177 n-C 4 H 9 CH 3 Ph CH 3 13.178 n-C 4 H 9 CH 3 2-Cl(Ph) CH 3 13.179 n-C 4 H 9 CH 3 3-Cl(Ph) CH 3 13.180 n-C 4 H 9 CH 3 4-Cl(Ph) CH 3 13.181 n-C 4 H 9 CH 3 4-Br(Ph) CH 3 13.182 n-C 4 H 9 CH 3 4-F(Ph) CH 3 13.183 n-C 4 H 9 CH 3 4-OCH 3 (Ph) CH 3 13.184 n-C 4 H 9 CH 3 4-CH 3 (Ph) CH 3 13.185 n-C 4 H 9 CH 3 4-NO 2 (Ph) CH 3 13.186 n-C 4 H 9 CH 3 2,4-Cl(Ph) CH 3 13.187 n-C 4 H 9 CH 3 2,4-F(Ph) CH 3 13.188 n-C 4 H 9 CH 3 4-CF 3 (Ph) CH 3 13.189 Ph H Ph H 13.190 Ph H Ph CH 3 13.191 Ph H Ph C 2 H 5 13.192 Ph H Ph n-C 3 H 7 13.193 Ph H Ph iso-C 3 H 7 13.194 Ph H Ph n-C 4 H 9 13.195 Ph H Ph iso-C 4 H 9 13.196 Ph H Ph C(CH 3 ) 3 13.197 Ph H Ph CH 2 C≡CH 13.198 Ph H 2-Cl(Ph) CH 3 13.199 Ph H 4-Cl(Ph) CH 3 13.200 Ph CH 3 Ph CH 3 13.201 Ph CH 3 2-Cl(Ph) CH 3 13.202 Ph CH 3 3-Cl(Ph) CH 3 13.203 Ph CH 3 4-Cl(Ph) CH 3 13.204 Ph CH 3 4-Br(Ph) CH 3 13.205 Ph CH 3 4-F(Ph) CH 3 13.206 Ph CH 3 4-OCH 3 (Ph) CH 3 13.207 Ph CH 3 4-CH 3 (Ph) CH 3 13.208 Ph CH 3 4-NO 2 (Ph) CH 3 13.209 Ph CH 3 2,4-Cl(Ph) CH 3 13.210 Ph CH 3 2,4-F(Ph) CH 3 13.211 CN H Ph H 13.212 CN H Ph CH 3 13.213 CN H Ph C 2 H 5 13.214 CN H Ph n-C 3 H 7 13.215 CN H Ph iso-C 3 H 7 13.216 CN H Ph n-C 4 H 9 13.217 CN H Ph iso-C 4 H 9 13.218 CN H Ph C(CH 3 ) 3 13.219 CN H Ph CH 2 C≡CH 13.220 CN H 2-Cl(Ph) CH 3 13.221 CN H 4-Cl(Ph) CH 3 13.222 CN CH 3 Ph H 13.223 CN CH 3 2-Cl(Ph) CH 3 13.224 CN CH 3 3-Cl(Ph) CH 3 13.225 CN CH 3 4-Cl(Ph) CH 3 13.226 CN CH 3 4-Br(Ph) CH 3 13.227 CN CH 3 4-F(Ph) CH 3 13.228 CN CH 3 4-OCH 3 (Ph) CH 3 13.229 CN CH 3 4-CH 3 (Ph) CH 3 13.230 CN CH 3 4-NO 2 (Ph) CH 3 13.231 CN CH 3 2,4-Cl(Ph) CH 3 13.232 CN CH 3 2,4-F(Ph) CH 3 13.233 H H 1-napthyl H 13.234 CH 3 H 1-napthyl CH 3 13.235 C 2 H 5 H 1-napthyl CH 3 13.236 n-C 3 H 7 H 1-napthyl CH 3 13.237 iso-C 3 H 7 H 1-napthyl CH 3 13.238 n-C 4 H 9 H 1-napthyl CH 3 13.239 iso-C 4 H 9 H 1-napthyl CH 3 13.240 cyclopropyl H 1-napthyl CH 3 13.241 1-CH 3 -cyclopropyl H 1-napthyl CH 3 13.242 CN H 1-napthyl CH 3 13.243 Ph CH 3 1-napthyl CH 3 13.244 H CH 3 1-napthyl CH 3 13.245 CH 3 CH 3 1-napthyl CH 3 13.246 C 2 H 5 CH 3 1-napthyl CH 3 13.247 n-C 3 H 7 CH 3 1-napthyl CH 3 13.248 iso-C 3 H 7 CH 3 1-napthyl CH 3 13.249 n-C 4 H 9 CH 3 1-napthyl CH 3 13.250 iso-C 4 H 9 CH 3 1-napthyl CH 3 13.251 cyclopropyl CH 3 1-napthyl CH 3 13.252 1-CH 3 -cyclopropyl CH 3 1-napthyl CH 3 13.253 CN CH 3 1-napthyl CH 3 13.254 Ph CH 3 1-napthyl CH 3 13.255 H H 2-napthyl H 13.256 CH 3 H 2-napthyl CH 3 13.257 C 2 H 5 H 2-napthyl C 2 H 5 13.258 n-C 3 H 7 H 2-napthyl n-C 3 H 7 13.259 iso-C 3 H 7 H 2-napthyl iso-C 3 H 7 13.260 n-C 4 H 9 H 2-napthyl n-C 4 H 9 13.261 iso-C 4 H 9 H 2-napthyl iso-C 4 H 9 13.262 cyclopropyl H 2-napthyl C(CH 3 ) 3 13.263 1-CH 3 -cyclopropyl H 2-napthyl CH 2 C≡CH 13.264 CN H 2-napthyl CH 2 Ph 13.265 Ph H 2-napthyl CH 2 Ph 13.266 H CH 3 2-napthyl CH 3 13.267 CH 3 CH 3 2-napthyl CH 3 13.268 C 2 H 5 CH 3 2-napthyl CH 3 13.269 n-C 3 H 7 CH 3 2-napthyl CH 3 13.270 iso-C 3 H 7 CH 3 2-napthyl CH 3 13.271 n-C 4 H 9 CH 3 2-napthyl CH 3 13.272 iso-C 4 H 9 CH 3 2-napthyl CH 3 13.273 cyclopropyl CH 3 2-napthyl CH 3 13.274 1-CH 3 -cyclopropyl CH 3 2-napthyl CH 3 13.275 CN CH 3 2-napthyl CH 3 13.276 Ph CH 3 2-napthyl CH 3 13.277 2-Cl(Ph) CH 3 2-napthyl CH 3 13.278 3-Cl(Ph) CH 3 2-napthyl CH 3 13.279 4-Cl(Ph) CH 3 2-napthyl CH 3 13.280 4-Br(Ph) CH 3 2-napthyl CH 3 13.281 4-F(Ph) CH 3 2-napthyl CH 3 13.282 4-OCH 3 (Ph) CH 3 2-napthyl CH 3 13.283 4-CH 3 (Ph) CH 3 2-napthyl CH 3 13.284 3-CF 3 (Ph) CH 3 2-napthyl CH 3 13.285 CH 3 C 2 H 5 Ph CH 3 13.286 CH 3 C 2 H 5 2-Cl(Ph) CH 3 13.287 CH 3 C 2 H 5 3-Cl(Ph) CH 3 13.288 CH 3 C 2 H 5 4-Cl(Ph) CH 3 13.289 CH 3 C 2 H 5 4-Br(Ph) CH 3 13.290 CH 3 C 2 H 5 4-F(Ph) CH 3 13.291 CH 3 C 2 H 5 4-OCH 3 (Ph) CH 3 13.292 CH 3 C 2 H 5 4-CH 3 (Ph) CH 3 13.293 CH 3 C 2 H 5 4-NO 2 (Ph) CH 3 13.294 CH 3 C 2 H 5 2,4-Cl(Ph) CH 3 13.295 CH 3 C 2 H 5 2,4-F(Ph) CH 3 13.296 CH 3 n-C 3 H 7 Ph CH 3 13.297 CH 3 n-C 3 H 7 2-Cl(Ph) CH 3 13.298 CH 3 n-C 3 H 7 3-Cl(Ph) CH 3 13.299 CH 3 n-C 3 H 7 4-Cl(Ph) CH 3 13.300 CH 3 n-C 3 H 7 4-Br(Ph) CH 3 13.301 CH 3 n-C 3 H 7 4-F(Ph) CH 3 13.302 CH 3 n-C 3 H 7 4-OCH 3 (Ph) CH 3 13.303 CH 3 n-C 3 H 7 4-CH 3 (Ph) CH 3 13.304 CH 3 n-C 3 H 7 4-NO 2 (Ph) CH 3 13.305 CH 3 n-C 3 H 7 2,4-Cl(Ph) CH 3 13.306 CH 3 n-C 3 H 7 2,4-F(Ph) CH 3 13.307 CH 3 iso-C 3 H 7 Ph CH 3 13.308 CH 3 iso-C 3 H 7 2-Cl(Ph) CH 3 13.309 CH 3 iso-C 3 H 7 3-Cl(Ph) CH 3 13.310 CH 3 iso-C 3 H 7 4-Cl(Ph) CH 3 13.311 CH 3 iso-C 3 H 7 4-Br(Ph) CH 3 13.312 CH 3 iso-C 3 H 7 4-F(Ph) CH 3 13.313 CH 3 iso-C 3 H 7 4-OCH 3 (Ph) CH 3 13.314 CH 3 iso-C 3 H 7 4-CH 3 (Ph) CH 3 13.315 CH 3 iso-C 3 H 7 4-NO 2 (Ph) CH 3 Typical compounds encompassed by the present invention of Formula I include those compounds of Formula VIII, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NOR 9 , and where R 2 , R 3 , R 7 and R 9 are defined in Table 14. Compd . R 2 R 3 R 7 R 9 14.1 H H Ph H 14.2 H H 4-Cl(Ph) H 14.3 H H 4-Br(Ph) H 14.4 H H 4-F(Ph) H 14.5 H H 4-OCH 3 (Ph) H 14.6 H H 4-CF 3 (Ph) H 14.7 H H Ph CH 3 14.8 H H 4-Cl(Ph) CH 3 14.9 H H 4-Br(Ph) CH 3 14.10 H H 4-F(Ph) CH 3 14.11 CH 3 H Ph H 14.12 CH 3 H 2-Cl(Ph) H 14.13 CH 3 H 3-Cl(Ph) H 14.14 CH 3 H 4-Cl(Ph) H 14.15 CH 3 H 2-Br(Ph) H 14.16 CH 3 H 3-Br(Ph) H 14.17 CH 3 H 4-Br(Ph) H 14.18 CH 3 H Ph CH 3 14.19 CH 3 H 2-Cl(Ph) CH 3 14.20 CH 3 H 3-Cl(Ph) CH 3 14.21 CH 3 H 4-Cl(Ph) CH 3 14.22 CH 3 H 2-F(Ph) CH 3 14.23 CH 3 H 3-F(Ph) CH 3 14.24 CH 3 H 4-F(Ph) CH 3 14.25 CH 3 H 2-CH 3 (Ph) CH 3 14.26 CH 3 H 3-CH 3 (Ph) CH 3 14.27 CH 3 H 2-CF 3 (Ph) CH 3 14.28 CH 3 H 3-CF 3 (Ph) CH 3 14.29 CH 3 H 4-CF 3 (Ph) CH 3 14.30 CH 3 H 2-OCH 3 (Ph) CH 3 14.31 CH 3 H 3-OCH 3 (Ph) CH 3 14.32 CH 3 H 4-OCH 3 (Ph) CH 3 14.33 CH 3 H 2,3-Cl(Ph) CH 3 14.34 CH 3 H 2,4-Cl(Ph) CH 3 14.35 CH 3 H 2,5-Cl(Ph) CH 3 14.36 CH 3 H 2,6-Cl(Ph) CH 3 14.37 CH 3 H 3,4-Cl(Ph) CH 3 14.38 CH 3 H 3,5-Cl(Ph) CH 3 14.39 CH 3 H Ph C 2 H 5 14.40 CH 3 H Ph n-C 3 H 7 14.41 CH 3 H Ph iso-C 3 H 7 14.42 CH 3 H Ph n-C 4 H 9 14.43 CH 3 H Ph C(CH 3 ) 3 14.44 CH 3 H Ph CH 2 C≡CH 14.45 C 2 H 5 H Ph CH 3 14.46 C 2 H 5 H 2-Cl(Ph) CH 3 14.47 C 2 H 5 H 3-Cl(Ph) CH 3 14.48 C 2 H 5 H 4-Cl(Ph) CH 3 14.49 C 2 H 5 H 4-Br(Ph) CH 3 14.50 C 2 H 5 H 4-F(Ph), CH 3 14.51 C 2 H 5 H 4-OCH 3 (Ph) CH 3 14.52 C 2 H 5 H 4-CH 3 (Ph) CH 3 14.53 C 2 H 5 H 4-NO 2 (Ph) CH 3 14.54 C 2 H 5 H 2,4-Cl(Ph) CH 3 14.55 C 2 H 5 H 2,4-F(Ph) CH 3 14.56 n-C 3 H 7 H Ph CH 3 14.57 n-C 3 H 7 H 2-Cl(Ph) CH 3 14.58 n-C 3 H 7 H 3-Cl(Ph) CH 3 14.59 n-C 3 H 7 H 4-Cl(Ph) CH 3 14.60 n-C 3 H 7 H 4-F(Ph) CH 3 14.61 n-C 3 H 7 H 3-OCH 3 (Ph) CH 3 14.62 n-C 3 H 7 H 4-OCH 3 (Ph) CH 3 14.63 n-C 3 H 7 H 4-CH 3 (Ph) CH 3 14.64 n-C 3 H 7 H 4-NO 2 (Ph) CH 3 14.65 n-C 3 H 7 H 2,4-Cl(Ph) CH 3 14.66 n-C 3 H 7 H 2,4-F(Ph) CH 3 14.67 iso-C 3 H 7 H Ph CH 3 14.68 iso-C 3 H 7 H 2-Cl(Ph) CH 3 14.69 iso-C 3 H 7 H 3-Cl(Ph) CH 3 14.70 iso-C 3 H 7 H 4-Cl(Ph) CH 3 14.71 iso-C 3 H 7 H 4-Br(Ph) CH 3 14.72 iso-C 3 H 7 H 4-F(Ph) CH 3 14.73 iso-C 3 H 7 H 4-OCH 3 (Ph) CH 3 14.74 iso-C 3 H 7 H 4-CH 3 (Ph) CH 3 14.75 iso-C 3 H 7 H 4-NO 2 (Ph) CH 3 14.76 iso-C 3 H 7 H 2,4-Cl(Ph) CH 3 14.77 iso-C 3 H 7 H 2,4-F(Ph) CH 3 14.78 n-C 4 H 9 H Ph CH 3 14.79 n-C 4 H 9 H 2-Cl(Ph) CH 3 14.80 n-C 4 H 9 H 3-Cl(Ph) CH 3 14.81 n-C 4 H 9 H 4-Cl(Ph) CH 3 14.82 n-C 4 H 9 H 4-Br(Ph) CH 3 14.83 n-C 4 H 9 H 4-F(Ph) CH 3 14.84 n-C 4 H 9 H 4-OCH 3 (Ph) CH 3 14.85 n-C 4 H 9 H 4-CH 3 (Ph) CH 3 14.86 n-C 4 H 9 H 4-NO 2 (Ph) CH 3 14.87 n-C 4 H 9 H 2,4-Cl(Ph) CH 3 14.88 n-C 4 H 9 H 2,4-F(Ph) CH 3 14.89 iso-C 4 H 9 H Ph CH 3 14.90 iso-C 4 H 9 H 2-Cl(Ph) CH 3 14.91 iso-C 4 H 9 H 3-Cl(Ph) CH 3 14.92 iso-C 4 H 9 H 4-Cl(Ph) CH 3 14.93 iso-C 4 H 9 H 4-F(Ph) CH 3 14.94 iso-C 4 H 9 H 3-OCH 3 (Ph) CH 3 14.95 iso-C 4 H 9 H 4-OCH 3 (Ph) CH 3 14.96 iso-C 4 H 9 H 4-CH 3 (Ph) CH 3 14.97 iso-C 4 H 9 H 4-NO 2 (Ph) CH 3 14.98 iso-C 4 H 9 H 2,4-Cl(Ph) CH 3 14.99 iso-C 4 H 9 H 2,4-F(Ph) CH 3 14.100 C(CH 3 ) 3 H Ph CH 3 14.101 C(CH 3 ) 3 H 2-Cl(Ph) CH 3 14.102 C(CH 3 ) 3 H 3-Cl(Ph) CH 3 14.103 C(CH 3 ) 3 H 4-Cl(Ph) CH 3 14.104 C(CH 3 ) 3 H 4-F(Ph) CH 3 14.105 C(CH 3 ) 3 H 3-OCH 3 (Ph) CH 3 14.106 C(CH 3 ) 3 H 4-OCH 3 (Ph) CH 3 14.107 C(CH 3 ) 3 H 4-CH 3 (Ph) CH 3 14.108 C(CH 3 ) 3 H 4-NO 2 (Ph) CH 3 14.109 C(CH 3 ) 3 H 2,4-Cl(Ph) CH 3 14.110 C(CH 3 ) 3 H 2,4-F(Ph) CH 3 14.111 cyclopropyl H Ph CH 3 14.112 cyclopropyl H 2-Cl(Ph) CH 3 14.113 cyclopropyl H 3-Cl(Ph) CH 3 14.114 cyclopropyl H 4-Cl(Ph) CH 3 14.115 cyclopropyl H 4-Br(Ph) CH 3 14.116 cyclopropyl H 3-OCH 3 (Ph) CH 3 14.117 cyclopropyl H 4-OCH 3 (Ph) CH 3 14.118 cyclopropyl H 4-CH 3 (Ph) CH 3 14.119 cyclopropyl H 4-NO 2 (Ph) CH 3 14.120 cyclopropyl H 2,4-Cl(Ph) CH 3 14.121 cyclopropyl H 2,4-F(Ph) CH 3 14.122 1-CH 3 -cyclopropyl H Ph CH 3 14.123 1-CH 3 -cyclopropyl H 2-Cl(Ph) CH 3 14.124 1-CH 3 -cyclopropyl H 3-Cl(Ph) CH 3 14.125 1-CH 3 -cyclopropyl H 4-Cl(Ph) CH 3 14.126 1-CH 3 -cyclopropyl H 4-Br(Ph) CH 3 14.127 1-CH 3 -cyclopropyl H 4-F(Ph) CH 3 14.128 1-CH 3 -cyclopropyl H 4-OCH 3 (Ph) CH 3 14.129 1-CH 3 -cyclopropyl H 4-CH 3 (Ph) CH 3 14.130 1-CH 3 -cyclopropyl H 4-NO 2 (Ph) CH 3 14.131 1-CH 3 -cyclopropyl H 2,4-Cl(Ph) CH 3 14.132 1-CH 3 -cyclopropyl H 2,4-F(Ph) CH 3 14.133 CH 3 CH 3 Ph H 14.134 CH 3 CH 3 Ph CH 3 14.135 CH 3 CH 3 Ph C 2 H 5 14.136 CH 3 CH 3 Ph n-C 3 H 7 14.137 CH 3 CH 3 Ph iso-C 3 H 7 14.138 CH 3 CH 3 Ph n-C 4 H 9 14.139 CH 3 CH 3 Ph iso-C 4 H 9 14.140 CH 3 CH 3 Ph C(CH 3 ) 3 14.141 CH 3 CH 3 Ph CH 2 C=CH 14.142 CH 3 CH 3 2-Cl(Ph) CH 3 14.143 CH 3 CH 3 3-Cl(Ph) CH 3 14.144 C 2 H 5 CH 3 Ph CH 3 14.145 C 2 H 5 CH 3 2-Cl(Ph) CH 3 14.146 C 2 H 5 CH 3 3-Cl(Ph) CH 3 14.147 C 2 H 5 CH 3 4-Cl(Ph) CH 3 14.148 C 2 H 5 CH 3 4-Br(Ph) CH 3 14.149 C 2 H 5 CH 3 4-F(Ph) CH 3 14.150 C 2 H 5 CH 3 4-OCH 3 (Ph) CH 3 14.151 C 2 H 5 CH 3 4-CH 3 (Ph) CH 3 14.152 C 2 H 5 CH 3 4-NO 2 (Ph) CH 3 14.153 C 2 H 5 CH 3 2,4-Cl(Ph) CH 3 14.154 C 2 H 5 CH 3 2,4-F(Ph) CH 3 14.155 n-C 3 H 7 CH 3 Ph CH 3 14.156 n-C 3 H 7 CH 3 2-Cl(Ph) CH 3 14.157 n-C 3 H 7 CH 3 3-Cl(Ph) CH 3 14.158 n-C 3 H 7 CH 3 4-Cl(Ph) CH 3 14.159 n-C 3 H 7 CH 3 4-Br(Ph) CH 3 14.160 n-C 3 H 7 CH 3 4-F(Ph) CH 3 14.161 n-C 3 H 7 CH 3 4-OCH 3 (Ph) CH 3 14.162 n-C 3 H 7 CH 3 4-CH 3 (Ph) CH 3 14.163 n-C 3 H 7 CH 3 4-NO 2 (Ph) CH 3 14.164 n-C 3 H 7 CH 3 2,4-Cl(Ph) CH 3 14.165 n-C 3 H 7 CH 3 2,4-F(Ph) CH 3 14.166 iso-C 3 H 7 CH 3 Ph CH 3 14.167 iso-C 3 H 7 CH 3 2-Cl(Ph) CH 3 14.168 iso-C 3 H 7 CH 3 3-Cl(Ph) CH 3 14.169 iso-C 3 H 7 CH 3 4-Cl(Ph) CH 3 14.170 iso-C 3 H 7 CH 3 4-Br(Ph) CH 3 14.171 iso-C 3 H 7 CH 3 4-F(Ph) CH 3 14.172 iso-C 3 H 7 CH 3 4-OCH 3 (Ph) CH 3 14.173 iso-C 3 H 7 CH 3 4-CH 3 (Ph) CH 3 14.174 iso-C 3 H 7 CH 3 4-NO 2 (Ph) CH 3 14.175 iso-C 3 H 7 CH 3 2,4-Cl(Ph) CH 3 14.176 iso-C 3 H 7 CH 3 2,4-F(Ph) CH 3 14.177 n-C 4 H 9 CH 3 Ph CH 3 14.178 n-C 4 H 9 CH 3 2-Cl(Ph) CH 3 14.179 n-C 4 H 9 CH 3 3-Cl(Ph) CH 3 14.180 n-C 4 H 9 CH 3 4-Cl(Ph) CH 3 14.181 n-C 4 H 9 CH 3 4-Br(Ph) CH 3 14.182 n-C 4 H 9 CH 3 4-F(Ph) CH 3 14.183 n-C 4 H 9 CH 3 4-OCH 3 (Ph) CH 3 14.184 n-C 4 H 9 CH 3 4-CH 3 (Ph) CH 3 14.185 n-C 4 H 9 CH 3 4-NO 2 (Ph) CH 3 14.186 n-C 4 H 9 CH 3 2,4-Cl(Ph) CH 3 14.187 n-C 4 H 9 CH 3 2,4-F(Ph) CH 3 14.188 n-C 4 H 9 CH 3 4-CF 3 (Ph) CH 3 14.189 Ph H Ph H 14.190 Ph H Ph CH 3 14.191 Ph H Ph C 2 H 5 14.192 Ph H Ph n-C 3 H 7 14.193 Ph H Ph iso-C 3 H 7 14.194 Ph H Ph n-C 4 H 9 14.195 Ph H Ph iso-C 4 H 9 14.196 Ph H Ph C(CH 3 ) 3 14.197 Ph H Ph CH 2 C≡CH 14.198 Ph H 2-Cl(Ph) CH 3 14.199 Ph H 4-Cl(Ph) CH 3 14.200 Ph CH 3 Ph CH 3 14.201 Ph CH 3 2-Cl(Ph) CH 3 14.202 Ph CH 3 3-Cl(Ph) CH 3 14.203 Ph CH 3 4-Cl(Ph) CH 3 14.204 Ph CH 3 4-Br(Ph) CH 3 14.205 Ph CH 3 4-F(Ph) CH 3 14.206 Ph CH 3 4-OCH 3 (Ph) CH 3 14.207 Ph CH 3 4-CH 3 (Ph) CH 3 14.208 Ph CH 3 4-NO 2 (Ph) CH 3 14.209 Ph CH 3 2,4-Cl(Ph) CH 3 14.210 Ph CH 3 2,4-F(Ph) CH 3 14.211 CN H Ph H 14.212 CN H Ph CH 3 14.213 CN H Ph C 2 H 5 14.214 CN H Ph n-C 3 H 7 14.215 CN H Ph iso-C 3 H 7 14.216 CN H Ph n-C 4 H 9 14.217 CN H Ph iso-C 4 H 9 14.218 CN H Ph C(CH 3 ) 3 14.219 CN H Ph CH 2 C≡CH 14.220 CN H 2-Cl(Ph) CH 3 14.221 CN H 4-Cl(Ph) CH 3 14.222 CN CH 3 Ph H 14.223 CN CH 3 2-Cl(Ph) CH 3 14.224 CN CH 3 3-Cl(Ph) CH 3 14.225 CN CH 3 4-Cl(Ph) CH 3 14.226 CN CH 3 4-Br(Ph) CH 3 14.227 CN CH 3 4-F(Ph) CH 3 14.228 CN CH 3 4-OCH 3 (Ph) CH 3 14.229 CN CH 3 4-CH 3 (Ph) CH 3 14.230 CN CH 3 4-NO 2 (Ph) CH 3 14.231 CN CH 3 2,4-Cl(Ph) CH 3 14.232 CN CH 3 2,4-F(Ph) CH 3 14.233 H H 1-napthyl H 14.234 CH 3 H 1-napthyl CH 3 14.235 C 2 H 5 H 1-napthyl CH 3 14.236 n-C 3 H 7 H 1-napthyl CH 3 14.237 iso-C 3 H 7 H 1-napthyl CH 3 14.238 n-C 4 H 9 H 1-napthyl CH 3 14.239 iso-C 4 H 9 H 1-napthyl CH 3 14.240 cyclopropyl H 1-napthyl CH 3 14.241 1-CH 3 -cyclopropyl H 1-napthyl CH 3 14.242 CN H 1-napthyl CH 3 14.243 Ph CH 3 1-napthyl CH 3 14.244 H CH 3 1-napthyl CH 3 14.245 CH 3 CH 3 1-napthyl CH 3 14.246 C 2 H 5 CH 3 1-napthyl CH 3 14.247 n-C 3 H 7 CH 3 1-napthyl CH 3 14.248 iso-C 3 H 7 CH 3 1-napthyl CH 3 14.249 n-C 4 H 9 CH 3 1-napthyl CH 3 14.250 iso-C 4 H 9 CH 3 1-napthyl CH 3 14.251 cyclopropyl CH 3 1-napthyl CH 3 14.252 1-CH 3 -cyclopropyl CH 3 1-napthyl CH 3 14.253 CN CH 3 1-napthyl CH 3 14.254 Ph CH 3 1-napthyl CH 3 14.255 H H 2-napthyl H 14.256 CH 3 H 2-napthyl CH 3 14.257 C 2 H 5 H 2-napthyl C 2 H 5 14.258 n-C 3 H 7 H 2-napthyl n-C 3 H 7 14.259 iso-C 3 H 7 H 2-napthyl iso-C 3 H 7 14.260 n-C 4 H 9 H 2-napthyl n-C 4 H 9 14.261 iso-C 4 H 9 H 2-napthyl iso-C 4 H 9 14.262 cyclopropyl H 2-napthyl C(CH 3 ) 3 14.263 1-CH 3 -cyclopropyl H 2-napthyl CH 2 C≡CH 14.264 CN H 2-napthyl CH 2 Ph 14.265 Ph H 2-napthyl CH 2 Ph 14.266 H CH 3 2-napthyl CH 3 14.267 CH 3 CH 3 2-napthyl CH 3 14.268 C 2 H 5 CH 3 2-napthyl CH 3 14.269 n-C 3 H 7 CH 3 2-napthyl CH 3 14.270 iso-C 3 H 7 CH 3 2-napthyl CH 3 14.271 n-C 4 H 9 CH 3 2-napthyl CH 3 14.272 iso-C 4 H 9 CH 3 2-napthyl CH 3 14.273 cyclo-C 3 H 5 CH 3 2-napthyl CH 3 14.274 1-CH 3 -cyclopropyl CH 3 2-napthyl CH 3 14.275 CN CH 3 2-napthyl CH 3 14.276 Ph CH 3 2-napthyl CH 3 14.277 2-Cl(Ph) CH 3 2-napthyl CH 3 14.278 3-Cl(Ph) CH 3 2-napthyl CH 3 14.279 4-Cl(Ph) CH 3 2-napthyl CH 3 14.280 4-Br(Ph) CH 3 2-napthyl CH 3 14.281 4-F(Ph) CH 3 2-napthyl CH 3 14.282 4-OCH 3 (Ph) CH 3 2-napthyl CH 3 14.283 4-CH 3 (Ph) CH 3 2-napthyl CH 3 14.284 3-CF 3 (Ph) CH 3 2-napthyl CH 3 14.285 CH 3 C 2 H 5 Ph CH 3 14.286 CH 3 C 2 H 5 2-Cl(Ph) CH 3 14.287 CH 3 C 2 H 5 3-Cl(Ph) CH 3 14.288 CH 3 C 2 H 5 4-Cl(Ph) CH 3 14.289 CH 3 C 2 H 5 4-Br(Ph) CH 3 14.290 CH 3 C 2 H 5 4-F(Ph) CH 3 14.291 CH 3 C 2 H 5 4-OCH 3 (Ph) CH 3 14.292 CH 3 C 2 H 5 4-CH 3 (Ph) CH 3 14.293 CH 3 C 2 H 5 4-NO 2 (Ph) CH 3 14.294 CH 3 C 2 H 5 2,4-Cl(Ph) CH 3 14.295 CH 3 C 2 H 5 2,4-F(Ph) CH 3 14.296 CH 3 n-C 3 H 7 Ph CH 3 14.297 CH 3 n-C 3 H 7 2-Cl(Ph) CH 3 14.298 CH 3 n-C 3 H 7 3-Cl(Ph) CH 3 14.299 CH 3 n-C 3 H 7 4-Cl(Ph) CH 3 14.300 CH 3 n-C 3 H 7 4-Br(Ph) CH 3 14.301 CH 3 n-C 3 H 7 4-F(Ph) CH 3 14.302 CH 3 n-C 3 H 7 4-OCH 3 (Ph) CH 3 14.303 CH 3 n-C 3 H 7 4-CH 3 (Ph) CH 3 14.304 CH 3 n-C 3 H 7 4-NO 2 (Ph) CH 3 14.305 CH 3 n-C 3 H 7 2,4-Cl(Ph) CH 3 14.306 CH 3 n-C 3 H 7 2,4-F(Ph) CH 3 14.307 CH 3 iso-C 3 H 7 Ph CH 3 14.308 CH 3 iso-C 3 H 7 2-Cl(Ph) CH 3 14.309 CH 3 iso-C 3 H 7 3-Cl(Ph) CH 3 14.310 CH 3 iso-C 3 H 7 4-Cl(Ph) CH 3 14.311 CH 3 iso-C 3 H 7 4-Br(Ph) CH 3 14.312 CH 3 iso-C 3 H 7 4-F(Ph) CH 3 14.313 CH 3 iso-C 3 H 7 4-OCH 3 (Ph) CH 3 14.314 CH 3 iso-C 3 H 7 4-CH 3 (Ph) CH 3 14.315 CH 3 iso-C 3 H 7 4-NO 2 (Ph) CH 3 Typical compounds encompassed by the present invention of Formula I include those compounds of Formula IX, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NOR 9 , and where R 2 , R 3 , R 7 and R 9 are defined in Table 15. Compd R 2 R 3 R 7 R 9 15.1 H H Ph H 15.2 H H 4-Cl(Ph) H 15.3 H H 4-Br(Ph) H 15.4 H H 4-F(Ph) H 15.5 H H 4-OCH 3 (Ph) H 15.6 H H 4-CF 3 (Ph) H 15.7 H H Ph CH 3 15.8 H H 4-Cl(Ph) CH 3 15.9 H H 4-Br(Ph) CH 3 15.10 H H 4-F(Ph) CH 3 15.11 CH 3 H Ph H 15.12 CH 3 H 2-Cl(Ph) H 15.13 CH 3 H 3-Cl(Ph) H 15.14 CH 3 H 4-Cl(Ph) H 15.15 CH 3 H 2-Br(Ph) H 15.16 CH 3 H 3-Br(Ph) H 15.17 CH3 H 4-Br(Ph) H 15.18 CH 3 H Ph CH 3 15.19 CH 3 H 2-Cl(Ph) CH 3 15.20 CH 3 H 3-Cl(Ph) CH 3 15.21 CH 3 H 4-Cl(Ph) CH 3 15.22 CH 3 H 2-F(Ph) CH 3 15.23 CH 3 H 3-F(Ph) CH 3 15.24 CH 3 H 4-F(Ph) CH 3 15.25 CH 3 H 2-CH 3 (Ph) CH 3 15.26 CH 3 H 3-CH 3 (Ph) CH 3 15.27 CH 3 H 2-CF 3 (Ph) CH 3 15.28 CH 3 H 3-CF 3 (Ph) CH 3 15.29 CH 3 H 4-CF 3 (Ph) CH 3 15.30 CH 3 H 2-OCH 3 (Ph) CH 3 15.31 CH 3 H 3-OCH 3 (Ph) CH 3 15.32 CH 3 H 4-OCH 3 (Ph) CH 3 15.33 CH 3 H 2,3-Cl(Ph) CH 3 15.34 CH 3 H 2,4-Cl(Ph) CH 3 15.35 CH 3 H 2,5-Cl(Ph) CH 3 15.36 CH 3 H 2,6-Cl(Ph) CH 3 15.37 CH 3 H 3,4-Cl(Ph) CH 3 15.38 CH 3 H 3,5-Cl(Ph) CH 3 15.39 CH 3 H Ph C 2 H 5 15.40 CH 3 H Ph n-C 3 H 7 15.41 CH 3 H Ph iso-C 3 H 7 15.42 CH 3 H Ph n-C 4 H 9 15.43 CH 3 H Ph C(CH 3 ) 3 15.44 CH 3 H Ph CH 2 C≡CH 15.45 C 2 H 5 H Ph CH 3 15.46 C 2 H 5 H 2-Cl(Ph) CH 3 15.47 C 2 H 5 H 3-Cl(Ph) CH 3 15.48 C 2 H 5 H 4-Cl(Ph) CH 3 15.49 C 2 H 5 H 4-Br(Ph) CH 3 15.50 C 2 H 5 H 4-F(Ph) CH 3 15.51 C 2 H 5 H 4-OCH 3 (Ph) CH 3 15.52 C 2 H 5 H 4-CH 3 (Ph) CH 3 15.53 C 2 H 5 H 4-NO 2 (Ph) CH 3 15.54 C 2 H 5 H 2,4-Cl(Ph) CH 3 15.55 C 2 H 5 H 2,4-F(Ph) CH 3 15.56 n-C 3 H 7 H Ph CH 3 15.57 n-C 3 H 7 H 2-Cl(Ph) CH 3 15.58 n-C 3 H 7 H 3-Cl(Ph) CH 3 15.59 n-C 3 H 7 H 4-Cl(Ph) CH 3 15.60 n-C 3 H 7 H 4-F(Ph) CH 3 15.61 n-C 3 H 7 H 3-OCH 3 (Ph) CH 3 15.62 n-C 3 H 7 H 4-OCH 3 (Ph) CH 3 15.63 n-C 3 H 7 H 4-CH 3 (Ph) CH 3 15.64 n-C 3 H 7 H 4-NO 2 (Ph) CH 3 15.65 n-C 3 H 7 H 2,4-Cl(Ph) CH 3 15.66 n-C 3 H 7 H 2,4-F(Ph) CH 3 15.67 iso-C 3 H 7 H Ph CH 3 15.68 iso-C 3 H 7 H 2-Cl(Ph) CH 3 15.69 iso-C 3 H 7 H 3-Cl(Ph) CH 3 15.70 iso-C 3 H 7 H 4-Cl(Ph) CH 3 15.71 iso-C 3 H 7 H 4-Br(Ph) CH 3 15.72 iso-C 3 H 7 H 4-F(Ph) CH 3 15.73 iso-C 3 H 7 H 4-OCH 3 (Ph) CH 3 15.74 iso-C 3 H 7 H 4-CH 3 (Ph) CH 3 15.75 iso-C 3 H 7 H 4-NO 2 (Ph) CH 3 15.76 iso-C 3 H 7 H 2,4-Cl(Ph) CH 3 15.77 iso-C 3 H 7 H 2,4-F(Ph) CH 3 15.78 n-C 4 H 9 H Ph CH 3 15.79 n-C 4 H 9 H 2-Cl(Ph) CH 3 15.80 n-C 4 H 9 H 3-Cl(Ph) CH 3 15.81 n-C 4 H 9 H 4-Cl(Ph) CH 3 15.82 n-C 4 H 9 H 4-Br(Ph) CH 3 15.83 n-C 4 H 9 H 4-F(Ph) CH 3 15.84 n-C 4 H 9 H 4-OCH 3 (Ph) CH 3 15.85 n-C 4 H 9 H 4-CH 3 (Ph) CH 3 15.86 n-C 4 H 9 H 4-NO 2 (Ph) CH 3 15.87 n-C 4 H 9 H 2,4-Cl(Ph) CH 3 15.88 n-C 4 H 9 H 2,4-F(Ph) CH 3 15.89 iso-C 4 H 9 H Ph CH 3 15.90 iso-C 4 H 9 H 2-Cl(Ph) CH 3 15.91 iso-C 4 H 9 H 3-Cl(Ph) CH 3 15.92 iso-C 4 H 9 H 4-Cl(Ph) CH 3 15.93 iso-C 4 H 9 H 4-F(Ph) CH 3 15.94 iso-C 4 H 9 H 3-OCH 3 (Ph) CH 3 15.95 iso-C 4 H 9 H 4-OCH 3 (Ph) CH 3 15.96 iso-C 4 H 9 H 4-CH 3 (Ph) CH 3 15.97 iso-C 4 H 9 H 4-NO 2 (Ph) CH 3 15.98 iso-C 4 H 9 H 2,4-Cl(Ph) CH 3 15.99 iso-C 4 H 9 H 2,4-F(Ph) CH 3 15.100 C(CH 3 ) 3 H Ph CH 3 15.101 C(CH 3 ) 3 H 2-Cl(Ph) CH 3 15.102 C(CH 3 ) 3 H 3-Cl(Ph) CH 3 15.103 C(CH 3 ) 3 H 4-Cl(Ph) CH 3 15.104 C(CH 3 ) 3 H 4-F(Ph) CH 3 15.105 C(CH 3 ) 3 H 3-OCH 3 (Ph) CH 3 15.106 C(CH 3 ) 3 H 4-OCH 3 (Ph) CH 3 15.107 C(CH 3 ) 3 H 4-CH 3 (Ph) CH 3 15.108 C(CH 3 ) 3 H 4-NO 2 (Ph) CH 3 15.109 C(CH 3 ) 3 H 2,4-Cl(Ph) CH 3 15.110 C(CH 3 ) 3 H 2,4-F(Ph) CH 3 15.111 cyclopropyl H Ph CH 3 15.112 cyclopropyl H 2-Cl(Ph) CH 3 15.113 cyclopropyl H 3-Cl(Ph) CH 3 15.114 cyclopropyl H 4-Cl(Ph) CH 3 15.115 cyclopropyl H 4-Br(Ph) CH 3 15.116 cyclopropyl H 3-OCH 3 (Ph) CH 3 15.117 cyclopropyl H 4-OCH 3 (Ph) CH 3 15.118 cyclopropyl H 4-CH 3 (Ph) CH 3 15.119 cyclopropyl H 4-NO 2 (Ph) CH 3 15.120 cyclopropyl H 2,4-Cl(Ph) CH 3 15.121 cyclopropyl H 2,4-F(Ph) CH 3 15.122 1-CH 3 -cyclopropyl H Ph CH 3 15.123 1-CH 3 -cyclopropyl H 2-Cl(Ph) CH 3 15.124 1-CH 3 -cyclopropyl H 3-Cl(Ph) CH 3 15.125 1-CH 3 -cyclopropyl H 4-Cl(Ph) CH 3 15.126 1-CH 3 -cyclopropyl H 4-Br(Ph) CH 3 15.127 1-CH 3 -cyclopropyl H 4-F(Ph) CH 3 15.128 1-CH 3 -cyclopropyl H 4-OCH 3 (Ph) CH 3 15.129 1-CH 3 -cyclopropyl H 4-CH 3 (Ph) CH 3 15.130 1-CH 3 -cyclopropyl H 4-NO 2 (Ph) CH 3 15.131 1-CH 3 -cyclopropyl H 2,4-Cl(Ph) CH 3 15.132 1-CH 3 -cyclopropyl H 2,4-F(Ph) CH 3 15.133 CH 3 CH 3 Ph H 15.134 CH 3 CH 3 Ph CH 3 15.135 CH 3 CH 3 Ph C 2 H 5 15.136 CH 3 CH 3 Ph n-C 3 H 7 15.137 CH 3 CH 3 Ph iso-C 3 H 7 15.138 CH 3 CH 3 Ph n-C 4 H 9 15.139 CH 3 CH 3 Ph iso-C 4 H 9 15.140 CH 3 CH 3 Ph C(CH 3 ) 3 15.141 CH 3 CH 3 Ph CH 2 C≡CH 15.142 CH 3 CH 3 2-Cl(Ph) CH 3 15.143 CH 3 CH 3 3-Cl(Ph) CH 3 15.144 C 2 H 5 CH 3 Ph CH 3 15.145 C 2 H 5 CH 3 2-Cl(Ph) CH 3 15.146 C 2 H 5 CH 3 3-Cl(Ph) CH 3 15.147 C 2 H 5 CH 3 4-Cl(Ph) CH 3 15.148 C 2 H 5 CH 3 4-Br(Ph) CH 3 15.149 C 2 H 5 CH 3 4-F(Ph) CH 3 15.150 C 2 H 5 CH 3 4-OCH 3 (Ph) CH 3 15.151 C 2 H 5 CH 3 4-CH 3 (Ph) CH 3 15.152 C 2 H 5 CH 3 4-NO 2 (Ph) CH 3 15.153 C 2 H 5 CH 3 2,4-Cl(Ph) CH 3 15.154 C 2 H 5 CH 3 2,4-F(Ph) CH 3 15.155 n-C 3 H 7 CH 3 Ph CH 3 15.156 n-C 3 H 7 CH 3 2-Cl(Ph) CH 3 15.157 n-C 3 H 7 CH 3 3-Cl(Ph) CH 3 15.158 n-C 3 H 7 CH 3 4-Cl(Ph) CH 3 15.159 n-C 3 H 7 CH 3 4-Br(Ph) CH 3 15.160 n-C 3 H 7 CH 3 4-F(Ph) CH 3 15.161 n-C 3 H 7 CH 3 4-OCH 3 (Ph) CH 3 15.162 n-C 3 H 7 CH 3 4-CH 3 (Ph) CH 3 15.163 n-C 3 H 7 CH 3 4-NO 2 (Ph) CH 3 15.164 n-C 3 H 7 CH 3 2,4-Cl(Ph) CH 3 15.165 n-C 3 H 7 CH 3 2,4-F(Ph) CH 3 15.166 iso-C 3 H 7 CH 3 Ph CH 3 15.167 iso-C 3 H 7 CH 3 2-Cl(Ph) CH 3 15.168 iso-C 3 H 7 CH 3 3-Cl(Ph) CH 3 15.169 iso-C 3 H 7 CH 3 4-Cl(Ph) CH 3 15.170 iso-C 3 H 7 CH 3 4-Br(Ph) CH 3 15.171 iso-C 3 H 7 CH 3 4-F(Ph) CH 3 15.172 iso-C 3 H 7 CH 3 4-OCH 3 (Ph) CH 3 15.173 iso-C 3 H 7 CH 3 4-CH 3 (Ph) CH 3 15.174 iso-C 3 H 7 CH 3 4-NO 2 (Ph) CH 3 15.175 iso-C 3 H 7 CH 3 2,4-Cl(Ph) CH 3 15.176 iso-C 3 H 7 CH 3 2,4-F(Ph) CH 3 15.177 n-C 4 H 9 CH 3 Ph CH 3 15.178 n-C 4 H 9 CH 3 2-Cl(Ph) CH 3 15.179 n-C 4 H 9 CH 3 3-Cl(Ph) CH 3 15.180 n-C 4 H 9 CH 3 4-Cl(Ph) CH 3 15.181 n-C 4 H 9 CH 3 4-Br(Ph) CH 3 15.182 n-C 4 H 9 CH 3 4-F(Ph) CH 3 15.183 n-C 4 H 9 CH 3 4-OCH 3 (Ph) CH 3 15.184 n-C 4 H 9 CH 3 4-CH 3 (Ph) CH 3 15.185 n-C 4 H 9 CH 3 4-NO 2 (Ph) CH 3 15.186 n-C 4 H 9 CH 3 2,4-Cl(Ph) CH 3 15.187 n-C 4 H 9 CH 3 2,4-F(Ph) CH 3 15.188 n-C 4 H 9 CH 3 4-CF 3 (Ph) CH 3 15.189 Ph H Ph H 15.190 Ph H Ph CH 3 15.191 Ph H Ph C 2 H 5 15.192 Ph H Ph n-C 3 H 7 15.193 Ph H Ph iso-C 3 H 7 15.194 Ph H Ph n-C 4 H 9 15.195 Ph H Ph iso-C 4 H 9 15.196 Ph H Ph C(CH 3 ) 3 15.197 Ph H Ph CH 2 C≡CH 15.198 Ph H 2-Cl(Ph) CH 3 15.199 Ph H 4-Cl(Ph) CH 3 15.200 Ph CH 3 Ph CH 3 15.201 Ph CH 3 2-Cl(Ph) CH 3 15.202 Ph CH 3 3-Cl(Ph) CH 3 15.203 Ph CH 3 4-Cl(Ph) CH 3 15.204 Ph CH 3 4-Br(Ph) CH 3 15.205 Ph CH 3 4-F(Ph) CH 3 15.206 Ph CH 3 4-OCH 3 (Ph) CH 3 15.207 Ph CH 3 4-CH 3 (Ph) CH 3 15.208 Ph CH 3 4-NO 2 (Ph) CH 3 15.209 Ph CH 3 2,4-Cl(Ph) CH 3 15.210 Ph CH 3 2,4-F(Ph) CH 3 15.211 CN H Ph H 15.212 CN H Ph CH 3 15.213 CN H Ph C 2 H 5 15.214 CN H Ph n-C 3 H 7 15.215 CN H Ph iso-C 3 H 7 15.216 CN H Ph n-C 4 H 9 15.217 CN H Ph iso-C 4 H 9 15.218 CN H Ph C(CH 3 ) 3 15.219 CN H Ph CH 2 C≡CH 15.220 CN H 2-Cl(Ph) CH 3 15.221 CN H 4-Cl(Ph) CH 3 15.222 CN CH 3 Ph H 15.223 CN CH 3 2-Cl(Ph) CH 3 15.224 CN CH 3 3-Cl(Ph) CH 3 15.225 CN CH 3 4-Cl(Ph) CH 3 15.226 CN CH 3 4-Br(Ph) CH 3 15.227 CN CH 3 4-F(Ph) CH 3 15.228 CN CH 3 4-OCH 3 (Ph) CH 3 15.229 CN CH 3 4-CH 3 (Ph) CH 3 15.230 CN CH 3 4-NO 2 (Ph) CH 3 15.231 CN CH 3 2,4-Cl(Ph) CH 3 15.232 CN CH 3 2,4-F(Ph) CH 3 15.233 H H 1-napthyl H 15.234 CH 3 H 1-napthyl CH 3 15.235 C 2 H 5 H 1-napthyl CH 3 15.236 n-C 3 H 7 H 1-napthyl CH 3 15.237 iso-C 3 H 7 H 1-napthyl CH 3 15.238 n-C 4 H 9 H 1-napthyl CH 3 15.239 iso-C 4 H 9 H 1-napthyl CH 3 15.240 cyclopropyl H 1-napthyl CH 3 15.241 1-CH 3 -cyclopropyl H 1-napthyl CH 3 15.242 CN H 1-napthyl CH 3 15.243 Ph CH 3 1-napthyl CH 3 15.244 H CH 3 1-napthyl CH 3 15.245 CH 3 CH 3 1-napthyl CH 3 15.246 C 2 H 5 CH 3 1-napthyl CH 3 15.247 n-C 3 H 7 CH 3 1-napthyl CH 3 15.248 iso-C 3 H 7 CH 3 1-napthyl CH 3 15.249 n-C 4 H 9 CH 3 1-napthyl CH 3 15.250 iso-C 4 H 9 CH 3 1-napthyl CH 3 15.251 cyclopropyl CH 3 1-napthyl CH 3 15.252 1-CH 3 -cyclopropyl CH 3 1-napthyl CH 3 15.253 CN CH 3 1-napthyl CH 3 15.254 Ph CH 3 1-napthyl CH 3 15.255 H H 2-napthyl H 15.256 CH 3 H 2-napthyl CH 3 15.257 C 2 H 5 H 2-napthyl C 2 H 5 15.258 n-C 3 H 7 H 2-napthyl n-C 3 H 7 15.259 iso-C 3 H 7 H 2-napthyl iso-C 3 H 7 15.260 n-C 4 H 9 H 2-napthyl n-C 4 H 9 15.261 iso-C 4 H 9 H 2-napthyl iso-C 4 H 9 15.262 cyclopropyl H 2-napthyl C(CH 3 ) 3 15.263 1-CH 3 -cyclopropyl H 2-napthyl CH 2 C≡CH 15.264 CN H 2-napthyl CH 2 Ph 15.265 Ph H 2-napthyl CH 2 Ph 15.266 H CH 3 2-napthyl CH 3 15.267 CH 3 CH 3 2-napthyl CH 3 15.268 C 2 H 5 CH 3 2-napthyl CH 3 15.269 n-C 3 H 7 CH 3 2-napthyl CH 3 15.270 iso-C 3 H 7 CH 3 2-napthyl CH 3 15.271 n-C 4 H 9 CH 3 2-napthyl CH 3 15.272 iso-C 4 H 9 CH 3 2-napthyl CH 3 15.273 cyclopropyl CH 3 2-napthyl CH 3 15.274 1-CH 3 -cyclopropyl CH 3 2-napthyl CH 3 15.275 CN CH 3 2-napthyl CH 3 15.276 Ph CH 3 2-napthyl CH 3 15.277 2-Cl(Ph) CH 3 2-napthyl CH 3 15.278 3-Cl(Ph) CH 3 2-napthyl CH 3 15.279 4-Cl(Ph) CH 3 2-napthyl CH 3 15.280 4-Br(Ph) CH 3 2-napthyl CH 3 15.281 4-F(Ph) CH 3 2-napthyl CH 3 15.282 4-OCH 3 (Ph) CH 3 2-napthyl CH 3 15.283 4-CH 3 (Ph) CH 3 2-napthyl CH 3 15.284 3-CF 3 (Ph) CH 3 2-napthyl CH 3 15.285 CH 3 C 2 H 5 Ph CH 3 15.286 CH 3 C 2 H 5 2-Cl(Ph) CH 3 15.287 CH 3 C 2 H 5 3-Cl(Ph) CH 3 15.288 CH 3 C 2 H 5 4-Cl(Ph) CH 3 15.289 CH 3 C 2 H 5 4-Br(Ph) CH 3 15.290 CH 3 C 2 H 5 4-F(Ph) CH 3 15.291 CH 3 C 2 H 5 4-OCH 3 (Ph) CH 3 15.292 CH 3 C 2 H 5 4-CH 3 (Ph) CH 3 15.293 CH 3 C 2 H 5 4-NO 2 (Ph) CH 3 15.294 CH 3 C 2 H 5 2,4-Cl(Ph) CH 3 15.295 CH 3 C 2 H 5 2,4-F(Ph) CH 3 15.296 CH 3 n-C 3 H 7 Ph CH 3 15.297 CH 3 n-C 3 H 7 2-Cl(Ph) CH 3 15.298 CH 3 n-C 3 H 7 3-Cl(Ph) CH 3 15.299 CH 3 n-C 3 H 7 4-Cl(Ph) CH 3 15.300 CH 3 n-C 3 H 7 4-Br(Ph) CH 3 15.301 CH 3 n-C 3 H 7 4-F(Ph) CH 3 15.302 CH 3 n-C 3 H 7 4-OCH 3 (Ph) CH 3 15.303 CH 3 n-C 3 H 7 4-CH 3 (Ph) CH 3 15.304 CH 3 n-C 3 H 7 4-NO 2 (Ph) CH 3 15.305 CH 3 n-C 3 H 7 2,4-Cl(Ph) CH 3 15.306 CH 3 n-C 3 H 7 2,4-F(Ph) CH 3 15.307 CH 3 iso-C 3 H 7 Ph CH 3 15.308 CH 3 iso-C 3 H 7 2-Cl(Ph) CH 3 15.309 CH 3 iso-C 3 H 7 3-Cl(Ph) CH 3 15.310 CH 3 iso-C 3 H 7 4-Cl(Ph) CH 3 15.311 CH 3 iso-C 3 H 7 4-Br(Ph) CH 3 15.312 CH 3 iso-C 3 H 7 4-F(Ph) CH 3 15.313 CH 3 iso-C 3 H 7 4-OCH 3 (Ph) CH 3 15.314 CH 3 iso-C 3 H 7 4-CH 3 (Ph) CH 3 15.315 CH 3 iso-C 3 H 7 4-NO 2 (Ph) CH 3 Table 16: Compounds 16.1 to 16.226 are compounds of Formula VII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NOR 9 , where R 9 is CH 3 and R 2 , R 3 , and R 7 are defined in Table 4. Table 17 Compounds 17.1 to 17.226 are compounds of Formula VIII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NOR 9 , where R 9 is CH 3 and R 2 , R 3 , and R 7 are defined in Table 4. Table 18 Compounds 18.1 to 18.226 are compounds of Formula IX which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NOR 9 , where R 9 is CH 3 and R 2 , R 3 , and R 7 are defined in Table 4. Table 19: Compounds 19.1 to 19.221 are compounds of Formula VII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NOR 9 , where R 9 is C 2 H 5 and R 2 , R 3 , and R 7 are defined in Table 7. Table 20: Compounds 20.1 to 20.221 are compounds of Formula VIII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NOR 9 , where R 9 is C 2 H 5 and R 2 , R 3 , and R 7 are defined in Table 7. Table 21: Compounds 21.1 to 21.221 are compounds of Formula IX which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NOR 9 , where R 9 is C 2 H 5 and R 2 , R 3 , and R 7 are defined in Table 7. Table 22: Compounds 22.1 to 23.139 are compounds of Formula VII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NOR 9 , where R 9 is CH 2 Ph and R 2 , R 3 , and R 7 are defined in Table 10. Table 23: Compounds 23.1 to 23.139 are compounds of Formula VIII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NOR 9 , where R 9 is CH 2 Ph and R 2 , R 3 , and R 7 are defined in Table 10. Table 24: Compounds 24.1 to 24.139 are compounds of Formula IX which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NOR 9 , where R 9 is CH 2 Ph and R 2 , R 3 , and R 7 are defined in Table 10. Typical compounds encompassed by the present invention of Formula I include those compounds of Formula X, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, Z=NR 10 and R 10 is NR 8 R 9 , and where R 2 , R 3 , R 7 , R 8 and R 9 are defined in Table 25. Compd R 2 R 3 R 7 R 8 R 9 25.1 H H Ph CH 3 H 25.2 H H 4-Cl(Ph) CH 3 H 25.3 H H 4-Br(Ph) CH 3 H 25.4 H H 4-F(Ph) CH 3 H 25.5 H H 4-OCH 3 (Ph) CH 3 H 25.6 H H 4-CF 3 (Ph) CH 3 H 25.7 H H Ph CH 3 CH 3 25.8 H H 4-Cl(Ph) CH 3 CH 3 25.9 H H 4-Br(Ph) CH 3 CH 3 25.10 H H 4-F(Ph) CH 3 CH 3 25.11 CH 3 H Ph CH 3 H 25.12 CH 3 H 2-Cl(Ph) CH 3 H 25.13 CH 3 H 3-Cl(Ph) CH 3 H 25.14 CH 3 H 4-Cl(Ph) CH 3 H 25.15 CH 3 H 2-Br(Ph) CH 3 H 25.16 CH 3 H 3-Br(Ph) CH 3 H 25.17 CH 3 H 4-Br(Ph) CH 3 H 25.18 CH 3 H Ph CH 3 CH 3 25.19 CH 3 H 2-Cl(Ph) CH 3 CH 3 25.20 CH 3 H 3-Cl(Ph) CH 3 CH 3 25.21 CH 3 H 4-Cl(Ph) CH 3 CH 3 25.22 CH 3 H 2-Br(Ph) CH 3 CH 3 25.23 CH 3 H 3-Br(Ph) CH 3 CH 3 25.24 CH 3 H 4-Br(Ph) CH 3 CH 3 25.25 CH 3 H 2-CH 3 (Ph) CH 3 CH 3 25.26 CH 3 H 3-CH 3 (Ph) CH 3 CH 3 25.27 CH 3 H 2-CF 3 (Ph) CH 3 CH 3 25.28 CH 3 H 3-CF 3 (Ph) CH 3 CH 3 25.29 CH 3 H 4-CF 3 (Ph) CH 3 CH 3 25.30 CH 3 H 2-NO 2 (Ph) CH 3 CH 3 25.31 CH 3 H 3-NO 2 (Ph) CH 3 CH 3 25.32 CH 3 H 4-NO 2 (Ph) CH 3 CH 3 25.33 CH 3 H 2,3-Cl(Ph) CH 3 CH 3 25.34 CH 3 H 2,4-Cl(Ph) CH 3 CH 3 25.35 CH 3 H 2,5-Cl(Ph) CH 3 CH 3 25.36 CH 3 H 2,6-Cl(Ph) CH 3 CH 3 25.37 CH 3 H 3,4-Cl(Ph) CH 3 CH 3 25.38 CH 3 H 3,5-Cl(Ph) CH 3 CH 3 25.39 CH 3 H Ph C 2 H 5 CH 3 25.40 CH 3 H Ph n-C 3 H 7 CH 3 25.41 CH 3 H Ph iso-C 3 H 7 CH 3 25.42 CH 3 H Ph n-C 4 H 9 CH 3 25.43 CH 3 H Ph iso-C 4 H 9 CH 3 25.44 CH 3 H Ph C(CH 3 ) 3 CH 3 25.45 CH 3 H Ph H COCH 3 25.46 CH 3 H 2-Cl(Ph) H COCH 3 25.47 CH 3 H 3-Cl(Ph) H COCH 3 25.48 CH 3 H 4-Cl(Ph) H COCH 3 25.49 CH 3 H 4-Br(Ph) H COCH 3 25.50 CH 3 H 4-F(Ph) H COCH 3 25.51 CH 3 H 4-OCH 3 (Ph) H COCH 3 25.52 CH 3 H 4-CH 3 (Ph) H COCH 3 25.53 CH 3 H 4-NO 2 (Ph) H COCH 3 25.54 CH 3 H 2,4-Cl(Ph) H COCH 3 25.55 CH 3 H 2,4-F(Ph) H COCH 3 25.56 CH 3 H Ph CH 3 COCH 3 25.57 CH 3 H 2-Cl(Ph) CH 3 COCH 3 25.58 CH 3 H 3-Cl(Ph) CH 3 COCH 3 25.59 CH 3 H 4-Cl(Ph) CH 3 COCH 3 25.60 CH 3 H 4-F(Ph) CH 3 COCH 3 25.61 CH 3 H 3-OCH 3 (Ph) CH 3 COCH 3 25.62 CH 3 H 4-OCH 3 (Ph) CH 3 COCH 3 25.63 CH 3 H 4-CH 3 (Ph) CH 3 COCH 3 25.64 CH 3 H 4-NO 2 (Ph) CH 3 COCH 3 25.65 CH 3 H 2,4-Cl(Ph) CH 3 COCH 3 25.66 CH 3 H 2,4-F(Ph) CH 3 COCH 3 25.67 CH 3 H Ph H COPh 25.68 CH 3 H 2-Cl(Ph) H COPh 25.69 CH 3 H 3-Cl(Ph) H COPh 25.70 CH 3 H 4-Cl(Ph) H COPh 25.71 CH 3 H 4-Br(Ph) H COPh 25.72 CH 3 H 4-F(Ph) H COPh 25.73 CH 3 H 4-OCH 3 (Ph) H COPh 25.74 CH 3 H 4-CH 3 (Ph) H COPh 25.75 CH 3 H 4-NO 2 (Ph) H COPh 25.76 CH 3 H 2,4-Cl(Ph) H COPh 25.77 CH 3 H 2,4-F(Ph) H COPh 25.78 CH 3 H Ph CH 3 COPh 25.79 CH 3 H 2-Cl(Ph) CH 3 COPh 25.80 CH 3 H 3-Cl(Ph) CH 3 COPh 25.81 CH 3 H 4-Cl(Ph) CH 3 COPh 25.82 CH 3 H 4-Br(Ph) CH 3 COPh 25.83 CH 3 H 4-F(Ph) CH 3 COPh 25.84 CH 3 H 4-OCH 3 (Ph) CH 3 COPh 25.85 CH 3 H 4-CH 3 (Ph) CH 3 COPh 25.86 CH 3 H 4-NO 2 (Ph) CH 3 COPh 25.87 CH 3 H 2,4-Cl(Ph) CH 3 COPh 25.88 CH 3 H 2,4-F(Ph) CH 3 COPh 25.89 C 2 H 5 H Ph H COCH 3 25.90 C 2 H 5 H 2-Cl(Ph) H COCH 3 25.91 C 2 H 5 H 3-Cl(Ph) H COCH 3 25.92 C 2 H 5 H 4-Cl(Ph) H COCH 3 25.93 C 2 H 5 H 4-F(Ph) H COCH 3 25.94 C 2 H 5 H 3-OCH 3 (Ph) H COCH 3 25.95 C 2 H 5 H 4-OCH 3 (Ph) H COCH 3 25.96 C 2 H 5 H 4-CH 3 (Ph) H COCH 3 25.97 C 2 H 5 H 4-NO 2 (Ph) H COCH 3 25.98 C 2 H 5 H 2,4-Cl(Ph) H COCH 3 25.99 C 2 H 5 H 2,4-F(Ph) H COCH 3 25.100 C 2 H 5 H Ph CH 3 COCH 3 25.101 C 2 H 5 H 2-Cl(Ph) CH 3 COCH 3 25.102 C 2 H 5 H 3-Cl(Ph) CH 3 COCH 3 25.103 C 2 H 5 H 4-Cl(Ph) CH 3 COCH 3 25.104 C 2 H 5 H 4-F(Ph) CH 3 COCH 3 25.105 C 2 H 5 H 3-OCH 3 (Ph) CH 3 COCH 3 25.106 C 2 H 5 H 4-OCH 3 (Ph) CH 3 COCH 3 25.107 C 2 H 5 H 4-CH 3 (Ph) CH 3 COCH 3 25.108 C 2 H 5 H 4-NO 2 (Ph) CH 3 COCH 3 25.109 C 2 H 5 H 2,4-Cl(Ph) CH 3 COCH 3 25.110 C 2 H 5 H 2,4-F(Ph) CH 3 COCH 3 25.111 C 2 H 5 H Ph H COPh 25.112 C 2 H 5 H 2-Cl(Ph) H COPh 25.113 C 2 H 5 H 3-Cl(Ph) H COPh 25.114 C 2 H 5 H 4-Cl(Ph) H COPh 25.115 C 2 H 5 H 4-Br(Ph) H COPh 25.116 C 2 H 5 H 3-OCH 3 (Ph) H COPh 25.117 C 2 H 5 H 4-OCH 3 (Ph) H COPh 25.118 C 2 H 5 H 4-CH 3 (Ph) H COPh 25.119 C 2 H 5 H 4-NO 2 (Ph) H COPh 25.120 C 2 H 5 H 2,4-Cl(Ph) H COPh 25.121 C 2 H 5 H 2,4-F(Ph) H COPh 25.122 C 2 H 5 H Ph CH 3 COPh 25.123 C 2 H 5 H 2-Cl(Ph) CH 3 COPh 25.124 C 2 H 5 H 3-Cl(Ph) CH 3 COPh 25.125 C 2 H 5 H 4-Cl(Ph) CH 3 COPh 25.126 C 2 H 5 H 4-Br(Ph) CH 3 COPh 25.127 C 2 H 5 H 4-F(Ph) CH 3 COPh 25.128 C 2 H 5 H 4-OCH 3 (Ph) CH 3 COPh 25.129 C 2 H 5 H 4-CH 3 (Ph) CH 3 COPh 25.130 C 2 H 5 H 4-NO 2 (Ph) CH 3 COPh 25.131 C 2 H 5 H 2,4-Cl(Ph) CH 3 COPh 25.132 C 2 H 5 H 2,4-F(Ph) CH 3 COPh 25.133 CH 3 H Ph C 2 H 5 COCH 3 25.134 CH 3 H Ph n-C 3 H 7 COCH 3 25.135 CH 3 H Ph iso-C 3 H 7 COCH 3 25.136 CH 3 H Ph n-C 4 H 9 COCH 3 25.137 CH 3 H Ph iso-C 4 H 9 COCH 3 25.138 CH 3 H Ph C(CH 3 ) 3 COCH 3 25.139 CH 3 H 4-Cl(Ph) C 2 H 5 COCH 3 25.140 CH 3 H 4-Cl(Ph) n-C 3 H 7 COCH 3 25.141 CH 3 H 4-Cl(Ph) iso-C 3 H 7 COCH 3 25.142 CH 3 H 4-Cl(Ph) n-C 4 H 9 COCH 3 25.143 CH 3 H 4-Cl(Ph) iso-C 4 H 9 COCH 3 25.144 CH 3 H 4-Cl(Ph) C(CH 3 ) 3 COCH 3 25.145 CH 3 H Ph C 2 H 5 COPh 25.146 CH 3 H Ph n-C 3 H 7 COPh 25.147 CH 3 H Ph iso-C 3 H 7 COPh 25.148 CH 3 H Ph n-C 4 H 9 COPh 25.149 CH 3 H Ph C(CH 3 ) 3 COPh 25.150 CH 3 H 4-Cl(Ph) CH 3 COCH 2 Ph 25.151 CH 3 H 4-Br(Ph) CH 3 COCH 2 Ph 25.152 CH 3 H 4-F(Ph) CH 3 COCH 2 Ph 25.153 CH 3 H 4-OCH 3 (Ph) CH 3 COCH 2 Ph 25.154 CH 3 H 4-CH 3 (Ph) CH 3 COCH 2 Ph 25.155 CH 3 H 4-NO 2 (Ph) CH 3 COCH 2 Ph 25.156 CH 3 H 2,4-Cl(Ph) CH 3 COCH 2 Ph 25.157 CH 3 H 2,4-F(Ph) CH 3 COCH 2 Ph 25.158 CH 3 H 4-Cl(Ph) C 2 H 5 COCH 2 Ph 25.159 CH 3 H 4-Br(Ph) n-C 3 H 7 COCH 2 Ph 25.160 CH 3 H 4-F(Ph) iso-C 3 H 7 COCH 2 Ph 25.161 CH 3 H 4-OCH 3 (Ph) n-C 4 H 9 COCH 2 Ph 25.162 CH 3 H 4-CH 3 (Ph) iso-C 4 H 9 COCH 2 Ph 25.163 CH 3 H 4-NO 2 (Ph) C(CH 3 ) 3 COCH 2 Ph 25.164 Ph H Ph CH 3 H 25.165 Ph H 2-Cl(Ph) CH 3 H 25.166 Ph H 3-Cl(Ph) CH 3 H 25.167 Ph H 4-Cl(Ph) CH 3 H 25.168 Ph H 4-Br(Ph) CH 3 H 25.169 Ph H 4-F(Ph) CH 3 H 25.170 Ph H 4-OCH 3 (Ph) CH 3 H 25.171 Ph H 4-CH 3 (Ph) CH 3 H 25.172 Ph H 4-NO 2 (Ph) CH 3 H 25.173 Ph H 2,4-Cl(Ph) CH 3 H 25.174 Ph H Ph CH 3 CH 3 25.175 Ph H 2-Cl(Ph) CH 3 CH 3 25.176 Ph H 3-Cl(Ph) CH 3 CH 3 25.177 Ph H 4-Cl(Ph) CH 3 CH 3 25.178 Ph H 4-Br(Ph) CH 3 CH 3 25.179 Ph H 4-F(Ph) CH 3 CH 3 25.180 CN H 4-Cl(Ph) CH 3 H 25.181 CN H 4-Br(Ph) CH 3 H 25.182 CN H 4-F(Ph) CH 3 H 25.183 CN H 4-OCH 3 (Ph) CH 3 H 25.184 CN H 4-CH 3 (Ph) CH 3 H 25.185 CN H 4-NO 2 (Ph) CH 3 H 25.186 CN H 2,4-Cl(Ph) CH 3 H 25.187 CN H 2,4-F(Ph) CH 3 H 25.188 CN H 4-CF 3 (Ph) CH 3 H 25.189 CN H Ph CH 3 CH 3 25.190 CN H Ph CH 3 COCH 3 25.191 H H 1-napthyl CH 3 H 25.192 H H 1-napthyl CH 3 CH 3 25.193 H H 1-napthyl CH 3 COCH 3 25.194 H H 1-napthyl CH 3 COPh 25.195 CH 3 H 1-napthyl CH 3 H 25.196 CH 3 H 1-napthyl CH 3 CH 3 25.197 CH 3 H 1-napthyl CH 3 COCH 3 25.198 CH 3 H 1-napthyl CH 3 COPh 25.199 CH 3 H 1-napthyl CH 3 COCH 2 Ph 25.200 H H 1-napthyl CH 3 CO 2 CH 3 25.201 CH 3 H 1-napthyl CH 3 CO 2 CH 3 25.202 H H 2-napthyl CH 3 H 25.203 H H 2-napthyl CH 3 CH 3 25.204 H H 2-napthyl CH 3 COCH 3 25.205 H H 2-napthyl CH 3 COPh 25.206 CH 3 H 2-napthyl CH 3 H 25.207 CH 3 H 2-napthyl CH 3 CH 3 25.208 CH 3 H 2-napthyl CH 3 COCH 3 25.209 CH 3 H 2-napthyl CH 3 COPh 25.210 CH 3 H 2-napthyl CH 3 COCH 2 Ph 25.211 H H 2-napthyl CH 3 CO 2 CH 3 25.212 CH 3 H 2-napthyl CH 3 CO 2 CH 3 25.213 H CH 3 Ph CH 3 H 25.214 H CH 3 4-Cl(Ph) CH 3 H 25.215 H CH 3 4-Br(Ph) CH 3 H 25.216 H CH 3 4-F(Ph) CH 3 H 25.217 H CH 3 4-OCH 3 (Ph) CH 3 H 25.218 H CH 3 4-CF 3 (Ph) CH 3 H 25.219 H CH 3 Ph CH 3 CH 3 25.220 H CH 3 4-Cl(Ph) CH 3 CH 3 25.221 H CH 3 4-Br(Ph) CH 3 CH 3 25.222 H CH 3 4-F(Ph) CH 3 CH 3 25.223 H CH 3 4-OCH 3 (Ph) CH 3 CH 3 25.224 H CH 3 4-CF 3 (Ph) CH 3 CH 3 25.225 H CH 3 Ph CH 3 C 2 H 5 25.226 H CH 3 4-Cl(Ph) CH 3 n-C 3 H 7 25.227 H CH 3 4-Br(Ph) CH 3 iso-C 3 H 7 25.228 H CH 3 4-F(Ph) CH 3 n-C 4 H 9 25.229 H CH 3 4-OCH 3 (Ph) CH 3 iso-C 4 H 9 25.230 H CH 3 4-CH 3 (Ph) CH 3 C(CH 3 )a 25.231 H CH 3 4-NO 2 (Ph) CH 3 CH 3 25.232 H CH 3 2,4-Cl(Ph) CH 3 CH 3 25.233 H CH 3 Ph CH 3 COCH 3 25.234 H CH 3 4-Cl(Ph) CH 3 COCH 3 25.235 H CH 3 4-Br(Ph) CH 3 COCH 3 25.236 H CH 3 4-F(Ph) CH 3 COCH 3 25.237 H CH 3 4-OCH 3 (Ph) CH 3 COCH 3 25.238 H CH 3 4-CH 3 (Ph) CH 3 COCH 3 25.239 H CH 3 4-NO 2 (Ph) CH 3 COCH 3 25.240 H CH 3 2,4-Cl(Ph) CH 3 COCH 3 25.241 H CH 3 Ph CH 3 COPh 25.242 H CH 3 4-Cl(Ph) CH 3 COPh 25.243 H CH 3 4-Br(Ph) CH 3 COPh 25.244 H CH 3 4-F(Ph) CH 3 COPh 25.245 H CH 3 4-OCH 3 (Ph) CH 3 COPh 25.246 H CH 3 4-CH 3 (Ph) CH 3 COPh 25.247 H CH 3 4-NO 2 (Ph) CH 3 COPh 25.248 H CH 3 2,4-Cl(Ph) CH 3 COPh 25.249 CH 3 CH 3 Ph CH 3 H 25.250 CH 3 CH 3 4-Cl(Ph) CH 3 H 25.251 CH 3 CH 3 4-Br(Ph) CH 3 H 25.252 CH 3 CH 3 4-F(Ph) CH 3 H 25.253 CH 3 CH 3 4-OCH 3 (Ph) CH 3 H 25.254 CH 3 CH 3 4-CH 3 (Ph) CH 3 H 25.255 CH 3 CH 3 4-NO 2 (Ph) CH 3 H 25.256 CH 3 CH 3 2,4-Cl(Ph) CH 3 H 25.257 CH 3 CH 3 Ph CH 3 COCH 3 25.258 CH 3 CH 3 4-Cl(Ph) CH 3 COCH 3 25.259 CH 3 CH 3 4-Br(Ph) CH 3 COCH 3 25.260 CH 3 CH 3 4-F(Ph) CH 3 COCH 3 25.261 CH 3 CH 3 4-OCH 3 (Ph) CH 3 COCH 3 25.262 CH 3 CH 3 4-CH 3 (Ph) CH 3 COCH 3 25.263 CH 3 CH 3 4-NO 2 (Ph) CH 3 COCH 3 25.264 CH 3 CH 3 2,4-Cl(Ph) CH 3 COCH 3 25.265 CN CH 3 Ph CH 3 H 25.266 CN CH 3 4-Cl(Ph) CH 3 H 25.267 CN CH 3 4-Br(Ph) CH 3 H 25.268 CN CH 3 4-F(Ph) CH 3 H 25.269 CN CH 3 4-OCH 3 (Ph) CH 3 H 25.270 CN CH 3 4-CH 3 (Ph) CH 3 H 25.271 CN CH 3 4-NO 2 (Ph) CH 3 H 25.272 CN CH 3 2,4-Cl(Ph) CH 3 H 25.273 CN CH 3 Ph CH 3 CH 3 25.274 CN CH 3 4-Cl(Ph) CH 3 CH 3 25.275 CN CH 3 4-Br(Ph) CH 3 CH 3 25.276 CN CH 3 4-F(Ph) CH 3 CH 3 25.277 CN CH 3 4-OCH 3 (Ph) CH 3 CH 3 25.278 CN CH 3 4-CH 3 (Ph) CH 3 CH 3 25.279 CN CH 3 4-NO 2 (Ph) CH 3 CH 3 25.280 CN CH 3 2,4-Cl(Ph) CH 3 CH 3 25.281 CN CH 3 Ph CH 3 COCH 3 25.282 CN CH 3 4-Cl(Ph) CH 3 COCH 3 25.283 CN CH 3 4-Br(Ph) CH 3 COCH 3 25.284 CN CH 3 4-F(Ph) CH 3 COCH 3 25.285 CN CH 3 4-OCH 3 (Ph) CH 3 COCH 3 25.286 CN CH 3 4-CH 3 (Ph) CH 3 COCH 3 25.287 CN CH 3 4-NO 2 (Ph) CH 3 COCH 3 25.288 CN CH 3 2,4-Cl(Ph) CH 3 COCH 3 25.289 CN CH 3 Ph CH 3 COPh 25.290 CN CH 3 4-Cl(Ph) CH 3 COPh 25.291 CN CH 3 4-Br(Ph) CH 3 COPh 25.292 CN CH 3 4-F(Ph) CH 3 COPh 25.293 CN CH 3 4-NO 2 (Ph) CH 3 COPh 25.294 CN CH 3 2,4-Cl(Ph) CH 3 COPh 25.295 CN CH 3 2,4-F(Ph) CH 3 COPh 25.296 CN H Ph C 2 H 5 H 25.297 CN H 2-Cl(Ph) n-C 3 H 7 H 25.298 CN H 3-Cl(Ph) iso-C 3 H 7 H 25.299 CN H 4-Cl(Ph) n-C 4 H 9 H 25.300 CN H 4-Br(Ph) iso-C 4 H 9 H 25.301 CN H 4-F(Ph) C(CH 3 ) 3 H 25.302 CN H 4-OCH 3 (Ph) C 2 H 5 COCH 3 25.303 CN H 4-CH 3 (Ph) n-C 3 H 7 COCH 3 25.304 CN H 4-NO 2 (Ph) iso-C 3 H 7 COCH 3 25.305 CN H 2,4-Cl(Ph) n-C 4 H 9 COCH 3 25.306 CN H 2,4-F(Ph) iso-C 4 H 9 COCH 3 25.307 CN H Ph C(CH 3 ) 3 COCH 3 25.308 CN H 2-Cl(Ph) C 2 H 5 COPh 25.309 CN H 3-Cl(Ph) n-C 3 H 7 COPh 25.310 CN H 4-Cl(Ph) iso-C 3 H 7 COPh 25.311 CH 3 H 4-Br(Ph) n-C 4 H 9 COPh 25.312 CH 3 H 4-F(Ph) iso-C 4 H 9 COPh 25.313 CH 3 H 4-OCH 3 (Ph) C(CH 3 ) 3 COPh Typical compounds encompassed by the present invention of Formula I include those compounds of Formula XI, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, Z=NR 10 and Rio is NR 8 R 9 , and where R 2 , R 3 , R 7 , R 8 and R 9 are defined in Table 26. Compd . R 2 R 3 R 7 R 8 R 9 26.1 H H Ph CH 3 H 26.2 H H 4-Cl(Ph) CH 3 H 26.3 H H 4-Br(Ph) CH 3 H 26.4 H H 4-F(Ph) CH 3 H 26.5 H H 4-OCH 3 (Ph) CH 3 H 26.6 H H 4-CF 3 (Ph) CH 3 H 26.7 H H Ph CH 3 CH 3 26.8 H H 4-Cl(Ph) CH 3 CH 3 26.9 H H 4-Br(Ph) CH 3 CH 3 26.10 H H 4-F(Ph) CH 3 CH 3 26.11 CH 3 H Ph CH 3 H 26.12 CH 3 H 2-Cl(Ph) CH 3 H 26.13 CH 3 H 3-Cl(Ph) CH 3 H 26.14 CH 3 H 4-Cl(Ph) CH 3 H 26.15 CH 3 H 2-Br(Ph) CH 3 H 26.16 CH 3 H 3-Br(Ph) CH 3 H 26.17 CH 3 H 4-Br(Ph) CH 3 H 26.18 CH 3 H Ph CH 3 CH 3 26.19 CH 3 H 2-Cl(Ph) CH 3 CH 3 26.20 CH 3 H 3-Cl(Ph) CH 3 CH 3 26.21 CH 3 H 4-Cl(Ph) CH 3 CH 3 26.22 CH 3 H 2-Br(Ph) CH 3 CH 3 26.23 CH 3 H 3-Br(Ph) CH 3 CH 3 26.24 CH 3 H 4-Br(Ph) CH 3 CH 3 26.25 CH 3 H 2-CH 3 (Ph) CH 3 CH 3 26.26 CH 3 H 3-CH 3 (Ph) CH 3 CH 3 26.27 CH 3 H 2-CF 3 (Ph) CH 3 CH 3 26.28 CH 3 H 3-CF 3 (Ph) CH 3 CH 3 26.29 CH 3 H 4-CF 3 (Ph) CH 3 CH 3 26.30 CH 3 H 2-NO 2 (Ph) CH 3 CH 3 26.31 CH 3 H 3-NO 2 (Ph) CH 3 CH 3 26.32 CH 3 H 4-NO 2 (Ph) CH 3 CH 3 26.33 CH 3 H 2,3-Cl(Ph) CH 3 CH 3 26.34 CH 3 H 2,4-Cl(Ph) CH 3 CH 3 26.35 CH 3 H 2,5-Cl(Ph) CH 3 CH 3 26.36 CH 3 H 2,6-Cl(Ph) CH 3 CH 3 26.37 CH 3 H 3,4-Cl(Ph) CH 3 CH 3 26.38 CH 3 H 3,5-Cl(Ph) CH 3 CH 3 26.39 CH 3 H Ph C 2 H 5 CH 3 26.40 CH 3 H Ph n-C 3 H 7 CH 3 26.41 CH 3 H Ph iso-C 3 H 7 CH 3 26.42 CH 3 H Ph n-C 4 H 9 CH 3 26.43 CH 3 H Ph iso-C 4 H 9 CH 3 26.44 CH 3 H Ph C(CH 3 ) 3 CH 3 26.45 CH 3 H Ph H COCH 3 26.46 CH 3 H 2-Cl(Ph) H COCH 3 26.47 CH 3 H 3-Cl(Ph) H COCH 3 26.48 CH 3 H 4-Cl(Ph) H COCH 3 26.49 CH 3 H 4-Br(Ph) H COCH 3 26.50 CH 3 H 4-F(Ph) H COCH 3 26.51 CH 3 H 4-OCH 3 (Ph) H COCH 3 26.52 CH 3 H 4-CH 3 (Ph) H COCH 3 26.53 CH 3 H 4-NO 2 (Ph) H COCH 3 26.54 CH 3 H 2,4-Cl(Ph) H COCH 3 26.55 CH 3 H 2,4-F(Ph) H COCH 3 26.56 CH 3 H Ph CH 3 COCH 3 26.57 CH 3 H 2-Cl(Ph) CH 3 COCH 3 26.58 CH 3 H 3-Cl(Ph) CH 3 COCH 3 26.59 CH 3 H 4-Cl(Ph) CH 3 COCH 3 26.60 CH 3 H 4-F(Ph) CH 3 COCH 3 26.61 CH 3 H 3-OCH 3 (Ph) CH 3 COCH 3 26.62 CH 3 H 4-OCH 3 (Ph) CH 3 COCH 3 26.63 CH 3 H 4-CH 3 (Ph) CH 3 COCH 3 26.64 CH 3 H 4-NO 2 (Ph) CH 3 COCH 3 26.65 CH 3 H 2,4-Cl(Ph) CH 3 COCH 3 26.66 CH 3 H 2,4-F(Ph) CH 3 COCH 3 26.67 CH 3 H Ph H COPh 26.68 CH 3 H 2-Cl(Ph) H COPh 26.69 CH 3 H 3-Cl(Ph) H COPh 26.70 CH 3 H 4-Cl(Ph) H COPh 26.71 CH 3 H 4-Br(Ph) H COPh 26.72 CH 3 H 4-F(Ph) H COPh 26.73 CH 3 H 4-OCH 3 (Ph) H COPh 26.74 CH 3 H 4-CH 3 (Ph) H COPh 26.75 CH 3 H 4-NO 2 (Ph) H COPh 26.76 CH 3 H 2,4-Cl(Ph) H COPh 26.77 CH 3 H 2,4-F(Ph) H COPh 26.78 CH 3 H Ph CH 3 COPh 26.79 CH 3 H 2-Cl(Ph) CH 3 COPh 26.80 CH 3 H 3-Cl(Ph) CH 3 COPh 26.81 CH 3 H 4-Cl(Ph) CH 3 COPh 26.82 CH 3 H 4-Br(Ph) CH 3 COPh 26.83 CH 3 H 4-F(Ph) CH 3 COPh 26.84 CH 3 H 4-OCH 3 (Ph) CH 3 COPh 26.85 CH 3 H 4-CH 3 (Ph) CH 3 COPh 26.86 CH 3 H 4-NO 2 (Ph) CH 3 COPh 26.87 CH 3 H 2,4-Cl(Ph) CH 3 COPh 26.88 CH 3 H 2,4-F(Ph) CH 3 COPh 26.89 C 2 H 5 H Ph H COCH 3 26.90 C 2 H 5 H 2-Cl(Ph) H COCH 3 26.91 C 2 H 5 H 3-Cl(Ph) H COCH 3 26.92 C 2 H 5 H 4-Cl(Ph) H COCH 3 26.93 C 2 H 5 H 4-F(Ph) H COCH 3 26.94 C 2 H 5 H 3-OCH 3 (Ph) H COCH 3 26.95 C 2 H 5 H 4-OCH 3 (Ph) H COCH 3 26.96 C 2 H 5 H 4-CH 3 (Ph) H COCH 3 26.97 C 2 H 5 H 4-NO 2 (Ph) H COCH 3 26.98 C 2 H 5 H 2,4-Cl(Ph) H COCH 3 26.99 C 2 H 5 H 2,4-F(Ph) H COCH 3 26.100 C 2 H 5 H Ph CH 3 COCH 3 26.101 C 2 H 5 H 2-Cl(Ph) CH 3 COCH 3 26.102 C 2 H 5 H 3-Cl(Ph) CH 3 COCH 3 26.103 C 2 H 5 H 4-Cl(Ph) CH 3 COCH 3 26.104 C 2 H 5 H 4-F(Ph) CH 3 COCH 3 26.105 C 2 H 5 H 3-OCH 3 (Ph) CH 3 COCH 3 26.106 C 2 H 5 H 4-OCH 3 (Ph) CH 3 COCH 3 26.107 C 2 H 5 H 4-CH 3 (Ph) CH 3 COCH 3 26.108 C 2 H 5 H 4-NO 2 (Ph) CH 3 COCH 3 26.109 C 2 H 5 H 2,4-Cl(Ph) CH 3 COCH 3 26.110 C 2 H 5 H 2,4-F(Ph) CH 3 COCH 3 26.111 C 2 H 5 H Ph H COPh 26.112 C 2 H 5 H 2-Cl(Ph) H COPh 26.113 C 2 H 5 H 3-Cl(Ph) H COPh 26.114 C 2 H 5 H 4-Cl(Ph) H COPh 26.115 C 2 H 5 H 4-Br(Ph) H COPh 26.116 C 2 H 5 H 3-OCH 3 (Ph) H COPh 26.117 C 2 H 5 H 4-OCH 3 (Ph) H COPh 26.118 C 2 H 5 H 4-CH 3 (Ph) H COPh 26.119 C 2 H 5 H 4-NO 2 (Ph) H COPh 26.120 C 2 H 5 H 2,4-Cl(Ph) H COPh 26.121 C 2 H 5 H 2,4-F(Ph) H COPh 26.122 C 2 H 5 H Ph CH 3 COPh 26.123 C 2 H 5 H 2-Cl(Ph) CH 3 COPh 26.124 C 2 H 5 H 3-Cl(Ph) CH 3 COPh 26.125 C 2 H 5 H 4-Cl(Ph) CH 3 COPh 26.126 C 2 H 5 H 4-Br(Ph) CH 3 COPh 26.127 C 2 H 5 H 4-F(Ph) CH 3 COPh 26.128 C 2 H 5 H 4-OCH 3 (Ph) CH 3 COPh 26.129 C 2 H 5 H 4-CH 3 (Ph) CH 3 COPh 26.130 C 2 H 5 H 4-NO 2 (Ph) CH 3 COPh 26.131 C 2 H 5 H 2,4-Cl(Ph) CH 3 COPh 26.132 C 2 H 5 H 2,4-F(Ph) CH 3 COPh 26.133 CH 3 H Ph C 2 H 5 COCH 3 26.134 CH 3 H Ph n-C 3 H 7 COCH 3 26.135 CH 3 H Ph iso-C 3 H 7 COCH 3 26.136 CH 3 H Ph n-C 4 H 9 COCH 3 26.137 CH 3 H Ph iso-C 4 H 9 COCH 3 26.138 CH 3 H Ph C(CH 3 ) 3 COCH 3 26.139 CH 3 H 4-Cl(Ph) C 2 H 5 COCH 3 26.140 CH 3 H 4-Cl(Ph) n-C 3 H 7 COCH 3 26.141 CH 3 H 4-Cl(Ph) iso-C 3 H 7 COCH 3 26.142 CH 3 H 4-Cl(Ph) n-C 4 H 9 COCH 3 26.143 CH 3 H 4-Cl(Ph) iso-C 4 H 9 COCH 3 26.144 CH 3 H 4-Cl(Ph) C(CH 3 ) 3 COCH 3 26.145 CH 3 H Ph C 2 H 5 COPh 26.146 CH 3 H Ph n-C 3 H 7 COPh 26.147 CH 3 H Ph iso-C 3 H 7 COPh 26.148 CH 3 H Ph n-C 4 H 9 COPh 26.149 CH 3 H Ph C(CH 3 ) 3 COPh 26.150 CH 3 H 4-Cl(Ph) CH 3 COCH 2 Ph 26.151 CH 3 H 4-Br(Ph) CH 3 COCH 2 Ph 26.152 CH 3 H 4-F(Ph) CH 3 COCH 2 Ph 26.153 CH 3 H 4-OCH 3 (Ph) CH 3 COCH 2 Ph 26.154 CH 3 H 4-CH 3 (Ph) CH 3 COCH 2 Ph 26.155 CH 3 H 4-NO 2 (Ph) CH 3 COCH 2 Ph 26.156 CH 3 H 2,4-Cl(Ph) CH 3 COCH 2 Ph 26.157 CH 3 H 2,4-F(Ph) CH 3 COCH 2 Ph 26.158 CH 3 H 4-Cl(Ph) C 2 H 5 COCH 2 Ph 26.159 CH 3 H 4-Br(Ph) n-C 3 H 7 COCH 2 Ph 26.160 CH 3 H 4-F(Ph) iso-C 3 H 7 COCH 2 Ph 26.161 CH 3 H 4-OCH 3 (Ph) n-C 4 H 9 COCH 2 Ph 26.162 CH 3 H 4-CH 3 (Ph) iso-C 4 H 9 COCH 2 Ph 26.163 CH 3 H 4-NO 2 (Ph) C(CH 3 ) 3 COCH 2 Ph 26.164 Ph H Ph CH 3 H 26.165 Ph H 2-Cl(Ph) CH 3 H 26.166 Ph H 3-Cl(Ph) CH 3 H 26.167 Ph H 4-Cl(Ph) CH 3 H 26.168 Ph H 4-Br(Ph) CH 3 H 26.169 Ph H 4-F(Ph) CH 3 H 26.170 Ph H 4-OCH 3 (Ph) CH 3 H 26.171 Ph H 4-CH 3 (Ph) CH 3 H 26.172 Ph H 4-NO 2 (Ph) CH 3 H 26.173 Ph H 2,4-Cl(Ph) CH 3 H 26.174 Ph H Ph CH 3 CH 3 26.175 Ph H 2-Cl(Ph) CH 3 CH 3 26.176 Ph H 3-Cl(Ph) CH 3 CH 3 26.177 Ph H 4-Cl(Ph) CH 3 CH 3 26.178 Ph H 4-Br(Ph) CH 3 CH 3 26.179 Ph H 4-F(Ph) CH 3 CH 3 26.180 CN H 4-Cl(Ph) CH 3 H 26.181 CN H 4-Br(Ph) CH 3 H 26.182 CN H 4-F(Ph) CH 3 H 26.183 CN H 4-OCH 3 (Ph) CH 3 H 26.184 CN H 4-CH 3 (Ph) CH 3 H 26.185 CN H 4-NO 2 (Ph) CH 3 H 26.186 CN H 2,4-Cl(Ph) CH 3 H 26.187 CN H 2,4-F(Ph) CH 3 H 26.188 CN H 4-CF 3 (Ph) CH 3 H 26.189 CN H Ph CH 3 CH 3 26.190 CN H Ph CH 3 COCH 3 26.191 H H 1-napthyl CH 3 H 26.192 H H 1-napthyl CH 3 CH 3 26.193 H H 1-napthyl CH 3 COCH 3 26.194 H H 1-napthyl CH 3 COPh 26.195 CH 3 H 1-napthyl CH 3 H 26.196 CH 3 H 1-napthyl CH 3 CH 3 26.197 CH 3 H 1-napthyl CH 3 COCH 3 26.198 CH 3 H 1-napthyl CH 3 COPh 26.199 CH 3 H 1-napthyl CH 3 COCH 2 Ph 26.200 H H 1-napthyl CH 3 CO 2 CH 3 26.201 CH 3 H 1-napthyl CH 3 CO 2 CH 3 26.202 H H 2-napthyl CH 3 H 26.203 H H 2-napthyl CH 3 CH 3 26.204 H H 2-napthyl CH 3 COCH 3 26.205 H H 2-napthyl CH 3 COPh 26.206 CH 3 H 2-napthyl CH 3 H 26.207 CH 3 H 2-napthyl CH 3 CH 3 26.208 CH 3 H 2-napthyl CH 3 COCH 3 26.209 CH 3 H 2-napthyl CH 3 COPh 26.210 CH 3 H 2-napthyl CH 3 COCH 2 Ph 26.211 H H 2-napthyl CH 3 CO 2 CH 3 26.212 CH 3 H 2-napthyl CH 3 CO 2 CH 3 26.213 H CH 3 Ph CH 3 H 26.214 H CH 3 4-Cl(Ph) CH 3 H 26.215 H CH 3 4-Br(Ph) CH 3 H 26.216 H CH 3 4-F(Ph) CH 3 H 26.217 H CH 3 4-OCH 3 (Ph) CH 3 H 26.218 H CH 3 4-CF 3 (Ph) CH 3 H 26.219 H CH 3 Ph CH 3 CH 3 26.220 H CH 3 4-Cl(Ph) CH 3 CH 3 26.221 H CH 3 4-Br(Ph) CH 3 CH 3 26.222 H CH 3 4-F(Ph) CH 3 CH 3 26.223 H CH 3 4-OCH 3 (Ph) CH 3 CH 3 26.224 H CH 3 4-CF 3 (Ph) CH 3 CH 3 26.225 H CH 3 Ph CH 3 C 2 H 5 26.226 H CH 3 4-Cl(Ph) CH 3 n-C 3 H 7 26.227 H CH 3 4-Br(Ph) CH 3 iso-C 3 H 7 26.228 H CH 3 4-F(Ph) CH 3 n-C 4 H 9 26.229 H CH 3 4-OCH 3 (Ph) CH 3 iso-C 4 H 9 26.230 H CH 3 4-CH 3 (Ph) CH 3 C(CH 3 ) 3 26.231 H CH 3 4-NO 2 (Ph) CH 3 CH 3 26.232 H CH 3 2,4-Cl(Ph) CH 3 CH 3 26.233 H CH 3 Ph CH 3 COCH 3 26.234 H CH 3 4-Cl(Ph) CH 3 COCH 3 26.235 H CH 3 4-Br(Ph) CH 3 COCH 3 26.236 H CH 3 4-F(Ph) CH 3 COCH 3 26.237 H CH 3 4-OCH 3 (Ph) CH 3 COCH 3 26.238 H CH 3 4-CH 3 (Ph) CH 3 COCH 3 26.239 H CH 3 4-NO 2 (Ph) CH 3 COCH 3 26.240 H CH 3 2,4-Cl(Ph) CH 3 COCH 3 26.241 H CH 3 Ph CH 3 COPh 26.242 H CH 3 4-Cl(Ph) CH 3 COPh 26.243 H CH 3 4-Br(Ph) CH 3 COPh 26.244 H CH 3 4-F(Ph) CH 3 COPh 26.245 H CH 3 4-OCH 3 (Ph) CH 3 COPh 26.246 H CH 3 4-CH 3 (Ph) CH 3 COPh 26.247 H CH 3 4-NO 2 (Ph) CH 3 COPh 26.248 H CH 3 2,4-Cl(Ph) CH 3 COPh 26.249 CH 3 CH 3 Ph CH 3 H 26.250 CH 3 CH 3 4-Cl(Ph) CH 3 H 26.251 CH 3 CH 3 4-Br(Ph) CH 3 H 26.252 CH 3 CH 3 4-F(Ph) CH 3 H 26.253 CH 3 CH 3 4-OCH 3 (Ph) CH 3 H 26.254 CH 3 CH 3 4-CH 3 (Ph) CH 3 H 26.255 CH 3 CH 3 4-NO 2 (Ph) CH 3 H 26.256 CH 3 CH 3 2,4-Cl(Ph) CH 3 H 26.257 CH 3 CH 3 Ph CH 3 COCH 3 26.258 CH 3 CH 3 4-Cl(Ph) CH 3 COCH 3 26.259 CH 3 CH 3 4-Br(Ph) CH 3 COCH 3 26.260 CH 3 CH 3 4-F(Ph) CH 3 COCH 3 26.261 CH 3 CH 3 4-OCH 3 (Ph) CH 3 COCH 3 26.262 CH 3 CH 3 4-CH 3 (Ph) CH 3 COCH 3 26.263 CH 3 CH 3 4-NO 2 (Ph) CH 3 COCH 3 26.264 CH 3 CH 3 2,4-Cl(Ph) CH 3 COCH 3 26.265 CN CH 3 Ph CH 3 H 26.266 CN CH 3 4-Cl(Ph) CH 3 H 26.267 CN CH 3 4-Br(Ph) CH 3 H 26.268 CN CH 3 4-F(Ph) CH 3 H 26.269 CN CH 3 4-OCH 3 (Ph) CH 3 H 26.270 CN CH 3 4-CH 3 (Ph) CH 3 H 26.271 CN CH 3 4-NO 2 (Ph) CH 3 H 26.272 CN CH 3 2,4-Cl(Ph) CH 3 H 26.273 CN CH 3 Ph CH 3 CH 3 26.274 CN CH 3 4-Cl(Ph) CH 3 CH 3 26.275 CN CH 3 4-Br(Ph) CH 3 CH 3 26.276 CN CH 3 4-F(Ph) CH 3 CH 3 26.277 CN CH 3 4-OCH 3 (Ph) CH 3 CH 3 26.278 CN CH 3 4-CH 3 (Ph) CH 3 CH 3 26.279 CN CH 3 4-NO 2 (Ph) CH 3 CH 3 26.280 CN CH 3 2,4-Cl(Ph) CH 3 CH 3 26.281 CN CH 3 Ph CH 3 COCH 3 26.282 CN CH 3 4-Cl(Ph) CH 3 COCH 3 26.283 CN CH 3 4-Br(Ph) CH 3 COCH 3 26.284 CN CH 3 4-F(Ph) CH 3 COCH 3 26.285 CN CH 3 4-OCH 3 (Ph) CH 3 COCH 3 26.286 CN CH 3 4-CH 3 (Ph) CH 3 COCH 3 26.287 CN CH 3 4-NO 2 (Ph) CH 3 COCH 3 26.288 CN CH 3 2,4-Cl(Ph) CH 3 COCH 3 26.289 CN CH 3 Ph CH 3 COPh 26.290 CN CH 3 4-Cl(Ph) CH 3 COPh 26.291 CN CH 3 4-Br(Ph) CH 3 COPh 26.292 CN CH 3 4-F(Ph) CH 3 COPh 26.293 CN CH 3 4-NO 2 (Ph) CH 3 COPh 26.294 CN CH 3 2,4-Cl(Ph) CH 3 COPh 26.295 CN CH 3 2,4-F(Ph) CH 3 COPh 26.296 CN H Ph C 2 H 5 H 26.297 CN H 2-Cl(Ph) n-C 3 H 7 H 26.298 CN H 3-Cl(Ph) iso-C 3 H 7 H 26.299 CN H 4-Cl(Ph) n-C 4 H 9 H 26.300 CN H 4-Br(Ph) iso-C 4 H 9 H 26.301 CN H 4-F(Ph) C(CH 3 ) 3 H 26.302 CN H 4-OCH 3 (Ph) C 2 H 5 COCH 3 26.303 CN H 4-CH 3 (Ph) n-C 3 H 7 COCH 3 26.304 CN H 4-NO 2 (Ph) iso-C 3 H 7 COCH 3 26.305 CN H 2,4-Cl(Ph) n-C 4 H 9 COCH 3 26.306 CN H 2,4-F(Ph) iso-C 4 H 9 COCH 3 26.307 CN H Ph C(CH 3 ) 3 COCH 3 26.308 CN H 2-Cl(Ph) C 2 H 5 COPh 26.309 CN H 3-Cl(Ph) n-C 3 H 7 COPh 26.310 CN H 4-Cl(Ph) iso-C 3 H 7 COPh 26.311 CH 3 H 4-Br(Ph) n-C 4 H 9 COPh 26.312 CH 3 H 4-F(Ph) iso-C 4 H 9 COPh 26.313 CH 3 H 4-OCH 3 (Ph) C(CH 3 ) 3 COPh Typical compounds encompassed by the present invention of Formula I include those compounds of Formula XII, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, Z=NR 10 and R 10 is NR 8 R 9 , and where R 2 , R 3 , R 7 , R 8 and R 9 are defined in Table 27. Compd. R 2 R 3 R 7 R 8 R 9 27.1 H H Ph CH 3 H 27.2 H H 4-Cl(Ph) CH 3 H 27.3 H H 4-Br(Ph) CH 3 H 27.4 H H 4-F(Ph) CH 3 H 27.5 H H 4-OCH 3 (Ph) CH 3 H 27.6 H H 4-CF 3 (Ph) CH 3 H 27.7 H H Ph CH 3 CH 3 27.8 H H 4-Cl(Ph) CH 3 CH 3 27.9 H H 4-Br(Ph) CH 3 CH 3 27.10 H H 4-F(Ph) CH 3 CH 3 27.11 CH 3 H Ph CH 3 H 27.12 CH 3 H 2-Cl(Ph) CH 3 H 27.13 CH 3 H 3-Cl(Ph) CH 3 H 27.14 CH 3 H 4-Cl(Ph) CH 3 H 27.15 CH 3 H 2-Br(Ph) CH 3 H 27.16 CH 3 H 3-Br(Ph) CH 3 H 27.17 CH 3 H 4-Br(Ph) CH 3 H 27.18 CH 3 H Ph CH 3 CH 3 27.19 CH 3 H 2-Cl(Ph) CH 3 CH 3 27.20 CH 3 H 3-Cl(Ph) CH 3 CH 3 27.21 CH 3 H 4-Cl(Ph) CH 3 CH 3 27.22 CH 3 H 2-Br(Ph) CH 3 CH 3 27.23 CH 3 H 3-Br(Ph) CH 3 CH 3 27.24 CH 3 H 4-Br(Ph) CH 3 CH 3 27.25 CH 3 H 2-CH 3 (Ph) CH 3 CH 3 27.26 CH 3 H 3-CH 3 (Ph) CH 3 CH 3 27.27 CH 3 H 2-CF 3 (Ph) CH 3 CH 3 27.28 CH 3 H 3-CF 3 (Ph) CH 3 CH 3 27.29 CH 3 H 4-CF 3 (Ph) CH 3 CH 3 27.30 CH 3 H 2-NO 2 (Ph) CH 3 CH 3 27.31 CH 3 H 3-NO 2 (Ph) CH 3 CH 3 27.32 CH 3 H 4-NO 2 (Ph) CH 3 CH 3 27.33 CH 3 H 2,3-Cl(Ph) CH 3 CH 3 27.34 CH 3 H 2,4-Cl(Ph) CH 3 CH 3 27.35 CH 3 H 2,5-Cl(Ph) CH 3 CH 3 27.36 CH 3 H 2,6-Cl(Ph) CH 3 CH 3 27.37 CH 3 H 3,4-Cl(Ph) CH 3 CH 3 27.38 CH 3 H 3,5-Cl(Ph) CH 3 CH 3 27.39 CH 3 H Ph C 2 H 5 CH 3 27.40 CH 3 H Ph n-C 3 H 7 CH 3 27.41 CH 3 H Ph iso-C 3 H 7 CH 3 27.42 CH 3 H Ph n-C 4 H 9 CH 3 27.43 CH 3 H Ph iso-C 4 H 9 CH 3 27.44 CH 3 H Ph C(CH 3 ) 3 CH 3 27.45 CH 3 H Ph H COCH 3 27.46 CH 3 H 2-Cl(Ph) H COCH 3 27.47 CH 3 H 3-Cl(Ph) H COCH 3 27.48 CH 3 H 4-Cl(Ph) H COCH 3 27.49 CH 3 H 4-Br(Ph) H COCH 3 27.50 CH 3 H 4-F(Ph) H COCH 3 27.51 CH 3 H 4-OCH 3 (Ph) H COCH 3 27.52 CH 3 H 4-CH 3 (Ph) H COCH 3 27.53 CH 3 H 4-NO 2 (Ph) H COCH 3 27.54 CH 3 H 2,4-Cl(Ph) H COCH 3 27.55 CH 3 H 2,4-F(Ph) H COCH 3 27.56 CH 3 H Ph CH 3 COCH 3 27.57 CH 3 H 2-Cl(Ph) CH 3 COCH 3 27.58 CH 3 H 3-Cl(Ph) CH 3 COCH 3 27.59 CH 3 H 4-Cl(Ph) CH 3 COCH 3 27.60 CH 3 H 4-F(Ph) CH 3 COCH 3 27.61 CH 3 H 3-OCH 3 (Ph) CH 3 COCH 3 27.62 CH 3 H 4-OCH 3 (Ph) CH 3 COCH 3 27.63 CH 3 H 4-CH 3 (Ph) CH 3 COCH 3 27.64 CH 3 H 4-NO 2 (Ph) CH 3 COCH 3 27.65 CH 3 H 2,4-Cl(Ph) CH 3 COCH 3 27.66 CH 3 H 2,4-F(Ph) CH 3 COCH 3 27.67 CH 3 H Ph H COPh 27.68 CH 3 H 2-Cl(Ph) H COPh 27.69 CH 3 H 3-Cl(Ph) H COPh 27.70 CH 3 H 4-Cl(Ph) H COPh 27.71 CH 3 H 4-Br(Ph) H COPh 27.72 CH 3 H 4-F(Ph) H COPh 27.73 CH 3 H 4-OCH 3 (Ph) H COPh 27.74 CH 3 H 4-CH 3 (Ph) H COPh 27.75 CH 3 H 4-NO 2 (Ph) H COPh 27.76 CH 3 H 2,4-Cl(Ph) H COPh 27.77 CH 3 H 2,4-F(Ph) H COPh 27.78 CH 3 H Ph CH 3 COPh 27.79 CH 3 H 2-Cl(Ph) CH 3 COPh 27.80 CH 3 H 3-Cl(Ph) CH 3 COPh 27.81 CH 3 H 4-Cl(Ph) CH 3 COPh 27.82 CH 3 H 4-Br(Ph) CH 3 COPh 27.83 CH 3 H 4-F(Ph) CH 3 COPh 27.84 CH 3 H 4-OCH 3 (Ph) CH 3 COPh 27.85 CH 3 H 4-CH 3 (Ph) CH 3 COPh 27.86 CH 3 H 4-NO 2 (Ph) CH 3 COPh 27.87 CH 3 H 2,4-Cl(Ph) CH 3 COPh 27.88 CH 3 H 2,4-F(Ph) CH 3 COPh 27.89 C 2 H 5 H Ph H COCH 3 27.90 C 2 H 5 H 2-Cl(Ph) H COCH 3 27.91 C 2 H 5 H 3-Cl(Ph) H COCH 3 27.92 C 2 H 5 H 4-Cl(Ph) H COCH 3 27.93 C 2 H 5 H 4-F(Ph) H COCH 3 27.94 C 2 H 5 H 3-OCH 3 (Ph) H COCH 3 27.95 C 2 H 5 H 4-OCH 3 (Ph) H COCH 3 27.96 C 2 H 5 H 4-CH 3 (Ph) H COCH 3 27.97 C 2 H 5 H 4-NO 2 (Ph) H COCH 3 27.98 C 2 H 5 H 2,4-Cl(Ph) H COCH 3 27.99 C 2 H 5 H 2,4-F(Ph) H COCH 3 27.100 C 2 H 5 H Ph CH 3 COCH 3 27.101 C 2 H 5 H 2-Cl(Ph) CH 3 COCH 3 27.102 C 2 H 5 H 3-Cl(Ph) CH 3 COCH 3 27.103 C 2 H 5 H 4-Cl(Ph) CH 3 COCH 3 27.104 C 2 H 5 H 4-F(Ph) CH 3 COCH 3 27.105 C 2 H 5 H 3-OCH 3 (Ph) CH 3 COCH 3 27.106 C 2 H 5 H 4-OCH 3 (Ph) CH 3 COCH 3 27.107 C 2 H 5 H 4-CH 3 (Ph) CH 3 COCH 3 27.108 C 2 H 5 H 4-NO 2 (Ph) CH 3 COCH 3 27.109 C 2 H 5 H 2,4-Cl(Ph) CH 3 COCH 3 27.110 C 2 H 5 H 2,4-F(Ph) CH 3 COCH 3 27.111 C 2 H 5 H Ph H COPh 27.112 C 2 H 5 H 2-Cl(Ph) H COPh 27.113 C 2 H 5 H 3-Cl(Ph) H COPh 27.114 C 2 H 5 H 4-Cl(Ph) H COPh 27.115 C 2 H 5 H 4-Br(Ph) H COPh 27.116 C 2 H 5 H 3-OCH 3 (Ph) H COPh 27.117 C 2 H 5 H 4-OCH 3 (Ph) H COPh 27.118 C 2 H 5 H 4-CH 3 (Ph) H COPh 27.119 C 2 H 5 H 4-NO 2 (Ph) H COPh 27.120 C 2 H 5 H 2,4-Cl(Ph) H COPh 27.121 C 2 H 5 H 2,4-F(Ph) H COPh 27.122 C 2 H 5 H Ph CH 3 COPh 27.123 C 2 H 5 H 2-Cl(Ph) CH 3 COPh 27.124 C 2 H 5 H 3-Cl(Ph) CH 3 COPh 27.125 C 2 H 5 H 4-Cl(Ph) CH 3 COPh 27.126 C 2 H 5 H 4-Br(Ph) CH 3 COPh 27.127 C 2 H 5 H 4-F(Ph) CH 3 COPh 27.128 C 2 H 5 H 4-OCH 3 (Ph) CH 3 COPh 27.129 C 2 H 5 H 4-CH 3 (Ph) CH 3 COPh 27.130 C 2 H 5 H 4-NO 2 (Ph) CH 3 COPh 27.131 C 2 H 5 H 2,4-Cl(Ph) CH 3 COPh 27.132 C 2 H 5 H 2,4-F(Ph) CH 3 COPh 27.133 CH 3 H Ph C 2 H 5 COCH 3 27.134 CH 3 H Ph n-C 3 H 7 COCH 3 27.135 CH 3 H Ph iso-C 3 H 7 COCH 3 27.136 CH 3 H Ph n-C 4 H 9 COCH 3 27.137 CH 3 H Ph iso-C 4 H 9 COCH 3 27.138 CH 3 H Ph C(CH 3 ) 3 COCH 3 27.139 CH 3 H 4-Cl(Ph) C 2 H 5 COCH 3 27.140 CH 3 H 4-Cl(Ph) n-C 3 H 7 COCH 3 27.141 CH 3 H 4-Cl(Ph) iso-C 3 H 7 COCH 3 27.142 CH 3 H 4-Cl(Ph) n-C 4 H 9 COCH 3 27.143 CH 3 H 4-Cl(Ph) iso-C 4 H 9 COCH 3 27.144 CH 3 H 4-Cl(Ph) C(CH 3 ) 3 COCH 3 27.145 CH 3 H Ph C 2 H 5 COPh 27.146 CH 3 H Ph n-C 3 H 7 COPh 27.147 CH 3 H Ph iso-C 3 H 7 COPh 27.148 CH 3 H Ph n-C 4 H 9 COPh 27.149 CH 3 H Ph C(CH 3 ) 3 COPh 27.150 CH 3 H 4-Cl(Ph) CH 3 COCH 2 Ph 27.151 CH 3 H 4-Br(Ph) CH 3 COCH 2 Ph 27.152 CH 3 H 4-F(Ph) CH 3 COCH 2 Ph 27.153 CH 3 H 4-OCH 3 (Ph) CH 3 COCH 2 Ph 27.154 CH 3 H 4-CH 3 (Ph) CH 3 COCH 2 Ph 27.155 CH 3 H 4-NO 2 (Ph) CH 3 COCH 2 Ph 27.156 CH 3 H 2,4-Cl(Ph) CH 3 COCH 2 Ph 27.157 CH 3 H 2,4-F(Ph) CH 3 COCH 2 Ph 27.158 CH 3 H 4-Cl(Ph) C 2 H 5 COCH 2 Ph 27.159 CH 3 H 4-Br(Ph) n-C 3 H 7 COCH 2 Ph 27.160 CH 3 H 4-F(Ph) iso-C 3 H 7 COCH 2 Ph 27.161 CH 3 H 4-OCH 3 (Ph) n-C 4 H 9 COCH 2 Ph 27.162 CH 3 H 4-CH 3 (Ph) iso-C 4 H 9 COCH 2 Ph 27.163 CH 3 H 4-NO 2 (Ph) C(CH 3 ) 3 COCH 2 Ph 27.164 Ph H Ph CH 3 H 27.165 Ph H 2-Cl(Ph) CH 3 H 27.166 Ph H 3-Cl(Ph) CH 3 H 27.167 Ph H 4-Cl(Ph) CH 3 H 27.168 Ph H 4-Br(Ph) CH 3 H 27.169 Ph H 4-F(Ph) CH 3 H 27.170 Ph H 4-OCH 3 (Ph) CH 3 H 27.171 Ph H 4-CH 3 (Ph) CH 3 H 27.172 Ph H 4-NO 2 (Ph) CH 3 H 27.173 Ph H 2,4-Cl(Ph) CH 3 H 27.174 Ph H Ph CH 3 CH 3 27.175 Ph H 2-Cl(Ph) CH 3 CH 3 27.176 Ph H 3-Cl(Ph) CH 3 CH 3 27.177 Ph H 4-Cl(Ph) CH 3 CH 3 27.178 Ph H 4-Br(Ph) CH 3 CH 3 27.179 Ph H 4-F(Ph) CH 3 CH 3 27.180 CN H 4-Cl(Ph) CH 3 H 27.181 CN H 4-Br(Ph) CH 3 H 27.182 CN H 4-F(Ph) CH 3 H 27.183 CN H 4-OCH 3 (Ph) CH 3 H 27.184 CN H 4-CH 3 (Ph) CH 3 H 27.185 CN H 4-NO 2 (Ph) CH 3 H 27.186 CN H 2,4-Cl(Ph) CH 3 H 27.187 CN H 2,4-F(Ph) CH 3 H 27.188 CN H 4-CF 3 (Ph) CH 3 H 27.189 CN H Ph CH 3 CH 3 27.190 CN H Ph CH 3 COCH 3 27.191 H H 1-napthyl CH 3 H 27.192 H H 1-napthyl CH 3 CH 3 27.193 H H 1-napthyl CH 3 COCH 3 27.194 H H 1-napthyl CH 3 COPh 27.195 CH 3 H 1-napthyl CH 3 H 27.196 CH 3 H 1-napthyl CH 3 CH 3 27.197 CH 3 H 1-napthyl CH 3 COCH 3 27.198 CH 3 H 1-napthyl CH 3 COPh 27.199 CH 3 H 1-napthyl CH 3 COCH 2 Ph 27.200 H H 1-napthyl CH 3 CO 2 CH 3 27.201 CH 3 H 1-napthyl CH 3 CO 2 CH 3 27.202 H H 2-napthyl CH 3 H 27.203 H H 2-napthyl CH 3 CH 3 27.204 H H 2-napthyl CH 3 COCH 3 27.205 H H 2-napthyl CH 3 COPh 27.206 CH 3 H 2-napthyl CH 3 H 27.207 CH 3 H 2-napthyl CH 3 CH 3 27.208 CH 3 H 2-napthyl CH 3 COCH 3 27.209 CH 3 H 2-napthyl CH 3 COPh 27.210 CH 3 H 2-napthyl CH 3 COCH 2 Ph 27.211 H H 2-napthyl CH 3 CO 2 CH 3 27.212 CH 3 H 2-napthyl CH 3 CO 2 CH 3 27.213 H CH 3 Ph CH 3 H 27.214 H CH 3 4-Cl(Ph) CH 3 H 27.215 H CH 3 4-Br(Ph) CH 3 H 27.216 H CH 3 4-F(Ph) CH 3 H 27.217 H CH 3 4-OCH 3 (Ph) CH 3 H 27.218 H CH 3 4-CF 3 (Ph) CH 3 H 27.219 H CH 3 Ph CH 3 CH 3 27.220 H CH 3 4-Cl(Ph) CH 3 CH 3 27.221 H CH 3 4-Br(Ph) CH 3 CH 3 27.222 H CH 3 4-F(Ph) CH 3 CH 3 27.223 H CH 3 4-OCH 3 (Ph) CH 3 CH 3 27.224 H CH 3 4-CF 3 (Ph) CH 3 CH 3 27.225 H CH 3 Ph CH 3 C 2 H 5 27.226 H CH 3 4-Cl(Ph) CH 3 n-C 3 H 7 27.227 H CH 3 4-Br(Ph) CH 3 iso-C 3 H 7 27.228 H CH 3 4-F(Ph) CH 3 n-C 4 H 9 27.229 H CH 3 4-OCH 3 (Ph) CH 3 iso-C 4 H 9 27.230 H CH 3 4-CH 3 (Ph) CH 3 C(CH 3 ) 3 27.231 H CH 3 4-NO 2 (Ph) CH 3 CH 3 27.232 H CH 3 2,4-Cl(Ph) CH 3 CH 3 27.233 H CH 3 Ph CH3 COCH 3 27.234 H CH 3 4-Cl(Ph) CH 3 COCH 3 27.235 H CH 3 4-Br(Ph) CH 3 COCH 3 27.236 H CH 3 4-F(Ph) CH 3 COCH 3 27.237 H CH 3 4-OCH 3 (Ph) CH 3 COCH 3 27.238 H CH 3 4-CH 3 (Ph) CH 3 COCH 3 27.239 H CH 3 4-NO 2 (Ph) CH 3 COCH 3 27.240 H CH 3 2,4-Cl(Ph) CH 3 COCH 3 27.241 H CH 3 Ph CH 3 COPh 27.242 H CH 3 4-Cl(Ph) CH 3 COPh 27.243 H CH 3 4-Br(Ph) CH 3 COPh 27.244 H CH 3 4-F(Ph) CH 3 COPh 27.245 H CH 3 4-OCH 3 (Ph) CH 3 COPh 27.246 H CH 3 4-CH 3 (Ph) CH 3 COPh 27.247 H CH 3 4-NO 2 (Ph) CH 3 COPh 27.248 H CH 3 2,4-Cl(Ph) CH 3 COPh 27.249 CH 3 CH 3 Ph CH 3 H 27.250 CH 3 CH 3 4-Cl(Ph) CH 3 H 27.251 CH 3 CH 3 4-Br(Ph) CH 3 H 27.252 CH 3 CH 3 4-F(Ph) CH 3 H 27.253 CH 3 CH 3 4-OCH 3 (Ph) CH 3 H 27.254 CH 3 CH 3 4-CH 3 (Ph) CH 3 H 27.255 CH 3 CH 3 4-NO 2 (Ph) CH 3 H 27.256 CH 3 CH 3 2,4-Cl(Ph) CH 3 H 27.257 CH 3 CH 3 Ph CH 3 COCH 3 27.258 CH 3 CH 3 4-Cl(Ph) CH 3 COCH 3 27.259 CH 3 CH 3 4-Br(Ph) CH 3 COCH 3 27.260 CH 3 CH 3 4-F(Ph) CH 3 COCH 3 27.261 CH 3 CH 3 4-OCH 3 (Ph) CH 3 COCH 3 27.262 CH 3 CH 3 4-CH 3 (Ph) CH 3 COCH 3 27.263 CH 3 CH 3 4-NO 2 (Ph) CH 3 COCH 3 27.264 CH 3 CH 3 2,4-Cl(Ph) CH 3 COCH 3 27.265 CN CH 3 Ph CH 3 H 27.266 CN CH 3 4-Cl(Ph) CH 3 H 27.267 CN CH 3 4-Br(Ph) CH 3 H 27.268 CN CH 3 4-F(Ph) CH 3 H 27.269 CN CH 3 4-OCH 3 (Ph) CH 3 H 27.270 CN CH 3 4-CH 3 (Ph) CH 3 H 27.271 CN CH 3 4-NO 2 (Ph) CH 3 H 27.272 CN CH 3 2,4-Cl(Ph) CH 3 H 27.273 CN CH 3 Ph CH 3 CH 3 27.274 CN CH 3 4-Cl(Ph) CH 3 CH 3 27.275 CN CH 3 4-Br(Ph) CH 3 CH 3 27.276 CN CH 3 4-F(Ph) CH 3 CH 3 27.277 CN CH 3 4-OCH 3 (Ph) CH 3 CH 3 27.278 CN CH 3 4-CH 3 (Ph) CH 3 CH 3 27.279 CN CH 3 4-NO 2 (Ph) CH 3 CH 3 27.280 CN CH 3 2,4-Cl(Ph) CH 3 CH 3 27.281 CN CH 3 Ph CH 3 COCH 3 27.282 CN CH 3 4-Cl(Ph) CH 3 COCH 3 27.283 CN CH 3 4-Br(Ph) CH 3 COCH 3 27.284 CN CH 3 4-F(Ph) CH 3 COCH 3 27.285 CN CH 3 4-OCH 3 (Ph) CH 3 COCH 3 27.286 CN CH 3 4-CH 3 (Ph) CH 3 COCH 3 27.287 CN CH 3 4-NO 2 (Ph) CH 3 COCH 3 27.288 CN CH 3 2,4-Cl(Ph) CH 3 COCH 3 27.289 CN CH 3 Ph CH 3 COPh 27.290 CN CH 3 4-Cl(Ph) CH 3 COPh 27.291 CN CH 3 4-Br(Ph) CH 3 COPh 27.292 CN CH 3 4-F(Ph) CH 3 COPh 27.293 CN CH 3 4-NO 2 (Ph) CH 3 COPh 27.294 CN CH 3 2,4-Cl(Ph) CH 3 COPh 27.295 CN CH 3 2,4-F(Ph) CH 3 COPh 27.296 CN H Ph C 2 H 5 H 27.297 CN H 2-Cl(Ph) n-C 3 H 7 H 27.298 CN H 3-Cl(Ph) iso-C 3 H 7 H 27.299 CN H 4-Cl(Ph) n-C 4 H 9 H 27.300 CN H 4-Br(Ph) iso-C 4 H 9 H 27.301 CN H 4-F(Ph) C(CH 3 ) 3 H 27.302 CN H 4-OCH 3 (Ph) C 2 H 5 COCH 3 27.303 CN H 4-CH 3 (Ph) n-C 3 H 7 COCH 3 27.304 CN H 4-NO 2 (Ph) iso-C 3 H 7 COCH 3 27.305 CN H 2,4-Cl(Ph) n-C 4 H 9 COCH 3 27.306 CN H 2,4-F(Ph) iso-C 4 H 9 COCH 3 27.307 CN H Ph C(CH 3 ) 3 COCH 3 27.308 CN H 2-Cl(Ph) C 2 H 5 COPh 27.309 CN H 3-Cl(Ph) n-C 3 H 7 COPh 27.310 CN H 4-Cl(Ph) iso-C 3 H 7 COPh 27.311 CH 3 H 4-Br(Ph) n-C 4 H 9 COPh 27.312 CH 3 H 4-F(Ph) iso-C 4 H 9 COPh 27.313 CH 3 H 4-OCH 3 (Ph) C(CH 3 ) 3 COPh Table 28 Compounds 28.1 to 28.226 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NR 10 , R 10 is NHCOCH 3 and where R 2 , R 3 , and R 7 are defined in Table 4. Table 29 Compounds 29.1 to 29.226 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NR 10 , R 10 is NHCOCH 3 and where R 2 , R 3 , and R 7 are defined in Table 4. Table 30 Compounds 30.1 to 30.226 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NR 10 , R 10 is NHCOCH 3 and where R 2 , R 3 , and R 7 are defined in Table 4. Table 31 Compounds 31.1 to 31.221 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NR 10 , R 10 is NHCOC 2 H 5 and where R 2 , R 3 , and R 7 are defined in Table 7. Table 32 Compounds 32.1 to 32.221 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NR 10 , R 10 is NHCOC 2 H 5 and where R 2 , R 3 , and R 7 are defined in Table 7. Table 33 Compounds 33.1 to 33.221 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NR 10 , R 10 is NHCOC 2 H 5 and where R 2 , R 3 , and R 7 are defined in Table 7. Table 34 Compounds 34.1 to 34.139 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NR 10 , R 10 is NHCOPh and where R 2 , R 3 , and R 7 are defined in Table 10. Table 35 Compounds 35.1 to 35.139 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NR 10 , R 10 is NHCOPh and where R 2 , R 3 , and R 7 are defined in Table 10. Table 36 Compounds 36.1 to 36.139 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NR 10 , R 10 is NHCOPh and where R 2 , R 3 , and R 7 are defined in Table 10. Typical compounds encompassed by the present invention of Formula I include those compounds of Formula X, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, Z=NR 10 , and where R 2 , R 3 , R 7 , and R 10 are defined in Table 37. Compd. R 2 R 3 R 7 R 10 37.1 H H Ph CH 3 37.2 H H 4-Cl(Ph) CH 3 37.3 H H 4-Br(Ph) CH 3 37.4 H H 4-F(Ph) CH 3 37.5 H H 4-OCH 3 (Ph) CH 3 37.6 H H 4-CF 3 (Ph) CH 3 37.7 H H Ph CH 3 37.8 H H 4-Cl(Ph) CH 3 37.9 H H 4-Br(Ph) CH 3 37.10 H H 4-F(Ph) CH 3 37.11 CH 3 H Ph CH 3 37.12 CH 3 H 2-Cl(Ph) CH 3 37.13 CH 3 H 3-Cl(Ph) CH 3 37.14 CH 3 H 4-Cl(Ph) CH 3 37.15 CH 3 H 2-Br(Ph) CH 3 37.16 CH 3 H 3-Br(Ph) CH 3 37.17 CH 3 H 4-Br(Ph) CH 3 37.18 CH 3 H Ph C 2 H 5 37.19 CH 3 H 2-Cl(Ph) C 2 H 5 37.20 CH 3 H 3-Cl(Ph) C 2 H 5 37.21 CH 3 H 4-Cl(Ph) C 2 H 5 37.22 CH 3 H 2-Br(Ph) C 2 H 5 37.23 CH 3 H 3-Br(Ph) C 2 H 5 37.24 CH 3 H 4-Br(Ph) C 2 H 5 37.25 CH 3 H 2-CH 3 (Ph) C 2 H 5 37.26 CH 3 H 3-CH 3 (Ph) C 2 H 5 37.27 CH 3 H 2-CF 3 (Ph) C 2 H 5 37.28 CH 3 H 3-CF 3 (Ph) C 2 H 5 37.29 CH 3 H 4-CF 3 (Ph) C 2 H 5 37.30 CH 3 H 2-NO 2 (Ph) C 2 H 5 37.31 CH 3 H 3-NO 2 (Ph) C 2 H 5 37.32 CH 3 H 4-NO 2 (Ph) C 2 H 5 37.33 CH 3 H 2,3-Cl(Ph) C 2 H 5 37.34 CH 3 H 2,4-Cl(Ph) C 2 H 5 37.35 CH 3 H 2,5-Cl(Ph) C 2 H 5 37.36 CH 3 H 2,6-Cl(Ph) C 2 H 5 37.37 CH 3 H 3,4-Cl(Ph) C 2 H 5 37.38 CH 3 H 3,5-Cl(Ph) C 2 H 5 37.39 CH 3 H Ph n-C 3 H 7 37.40 CH 3 H Ph iso-C 3 H 7 37.41 CH 3 H Ph n-C 4 H 9 37.42 CH 3 H Ph iso-C 4 H 9 37.43 CH 3 H Ph C(CH 3 ) 3 37.44 CH 3 H Ph CH 2 CH=CH 2 37.45 CH 3 H Ph CH 2 C≡CH 37.46 CH 3 H Ph PhCH 2 37.47 CH 3 CH 3 Ph CH 3 37.48 CH 3 CH 3 4-Cl(Ph) CH 3 37.49 CH 3 CH 3 4-Br(Ph) CH 3 37.50 CH 3 CH 3 4-F(Ph) CH 3 37.51 CH 3 CH 3 4-OCH 3 (Ph) CH 3 37.52 CH 3 CH 3 4-CH 3 (Ph) CH 3 37.53 CH 3 CH 3 4-NO 2 (Ph) CH 3 37.54 CH 3 CH 3 2,4-Cl(Ph) CH 3 37.55 CH 3 CH 3 2,4-F(Ph) CH 3 37.56 CH 3 CH 3 Ph C 2 H 5 37.57 CH 3 CH 3 2-Cl(Ph) C 2 H 5 37.58 CH 3 CH 3 3-Cl(Ph) C 2 H 5 37.59 CH 3 CH 3 4-Cl(Ph) C 2 H 5 37.60 CH 3 CH 3 4-F(Ph) C 2 H 5 37.61 CH 3 CH 3 3-OCH 3 (Ph) C 2 H 5 37.62 CH 3 CH 3 4-OCH 3 (Ph) C 2 H 5 37.63 CH 3 CH 3 4-CH 3 (Ph) C 2 H 5 37.64 CH 3 CH 3 4-NO 2 (Ph) C 2 H 5 37.65 CH 3 CH 3 2,4-Cl(Ph) C 2 H 5 37.66 CH 3 CH 3 2,4-F(Ph) C 2 H 5 37.67 CH 3 CH 3 Ph n-C 3 H 7 37.68 CH 3 CH 3 2-Cl(Ph) iso-C 3 H 7 37.69 CH 3 CH 3 3-Cl(Ph) n-C 4 H 9 37.70 CH 3 CH 3 4-Cl(Ph) iso-C 4 H 9 37.71 CH 3 CH 3 4-Br(Ph) sec-C 4 H 9 37.72 CH 3 CH 3 4-F(Ph) C(CH 3 ) 3 37.73 CH 3 CH 3 4-OCH 3 (Ph) CH 2 CH=CH 2 37.74 CH 3 CH 3 4-CH 3 (Ph) CH 2 C=CH 37.75 CH 3 CH 3 4-NO 2 (Ph) PhCH 2 37.76 CH 3 CH 3 2,4-Cl(Ph) PhCH 2 CH 2 37.77 CH 3 CH 3 2,4-F(Ph) PhCH 2 CH 2 37.78 C 2 H 5 H Ph CH 3 37.79 C 2 H 5 H 2-Cl(Ph) CH 3 37.80 C 2 H 5 H 3-Cl(Ph) CH 3 37.81 C 2 H 5 H 4-Cl(Ph) CH 3 37.82 C 2 H 5 H 4-Br(Ph) CH 3 37.83 C 2 H 5 H 4-F(Ph) CH 3 37.84 C 2 H 5 H 4-OCH 3 (Ph) CH 3 37.85 C 2 H 5 H 4-CH 3 (Ph) CH 3 37.86 C 2 H 5 H 4-NO 2 (Ph) CH 3 37.87 C 2 H 5 H 2,4-Cl(Ph) CH 3 37.88 C 2 H 5 H 2,4-F(Ph) CH 3 37.89 C 2 H 5 H Ph C 2 H 5 37.90 C 2 H 5 H 2-Cl(Ph) C 2 H 5 37.91 C 2 H 5 H 3-Cl(Ph) C 2 H 5 37.92 C 2 H 5 H 4-Cl(Ph) C 2 H 5 37.93 C 2 H 5 H 4-F(Ph) C 2 H 5 37.94 C 2 H 5 H 3-OCH 3 (Ph) C 2 H 5 37.95 C 2 H 5 H 4-OCH 3 (Ph) C 2 H 5 37.96 C 2 H 5 H 4-CH 3 (Ph) C 2 H 5 37.97 C 2 H 5 H 4-NO 2 (Ph) C 2 H 5 37.98 C 2 H 5 H 2,4-Cl(Ph) C 2 H 5 37.99 C 2 H 5 H 2,4-F(Ph) C 2 H 5 37.100 C 2 H 5 H Ph n-C 3 H 7 37.101 C 2 H 5 H 2-Cl(Ph)- iso-C 3 H 7 37.102 C 2 H 5 H 3-Cl(Ph) n-C 4 H 9 37.103 C 2 H 5 H 4-Cl(Ph) iso-C 4 H 9 37.104 C 2 H 5 H 4-F(Ph) sec-C 4 H 9 37.105 C 2 H 5 H 3-OCH 3 (Ph) C(CH 3 ) 3 37.106 C 2 H 5 H 4-OCH 3 (Ph) CH 2 CH=CH 2 37.107 C 2 H 5 H 4-CH 3 (Ph) CH 2 C≡CH 37.108 C 2 H 5 H 4-NO 2 (Ph) PhCH 2 37.109 C 2 H 5 H 2,4-Cl(Ph) PhCH 2 CH 2 37.110 C 2 H 5 H 2,4-F(Ph) CH 3 37.111 n-C 3 H 7 H Ph CH 3 37.112 n-C 3 H 7 H 2-Cl(Ph) CH 3 37.113 n-C 3 H 7 H 3-Cl(Ph) CH 3 37.114 n-C 3 H 7 H 4-Cl(Ph) CH 3 37.115 n-C 3 H 7 H 4-Br(Ph) CH 3 37.116 n-C 3 H 7 H 3-OCH 3 (Ph) CH 3 37.117 n-C 3 H 7 H 4-OCH 3 (Ph) CH 3 37.118 n-C 3 H 7 H 4-CH 3 (Ph) CH 3 37.119 n-C 3 H 7 H 4-NO 2 (Ph) CH 3 37.120 n-C 3 H 7 H 2,4-Cl(Ph) CH 3 37.121 n-C 3 H 7 H 2,4-F(Ph) CH 3 37.122 n-C 3 H 7 H Ph C 2 H 5 37.123 n-C 3 H 7 H 2-Cl(Ph) C 2 H 5 37.124 n-C 3 H 7 H 3-Cl(Ph) C 2 H 5 37.125 n-C 3 H 7 H 4-Cl(Ph) C 2 H 5 37.126 n-C 3 H 7 H 4-Br(Ph) C 2 H 5 37.127 n-C 3 H 7 H 4-F(Ph) C 2 H 5 37.128 n-C 3 H 7 H 4-OCH 3 (Ph) C 2 H 5 37.129 n-C 3 H 7 H 4-CH 3 (Ph) C 2 H 5 37.130 n-C 3 H 7 H 4-NO 2 (Ph) C 2 H 5 37.131 n-C 3 H 7 H 2,4-Cl(Ph) C 2 H 5 37.132 n-C 3 H 7 H 2,4-F(Ph) C 2 H 5 37.133 n-C 3 H 7 H Ph n-C 3 H 7 37.134 n-C 3 H 7 H Ph iso-C 3 H 7 37.135 n-C 3 H 7 H Ph n-C 4 H 9 37.136 n-C 3 H 7 H Ph iso-C 4 H 9 37.137 n-C 3 H 7 H Ph C(CH 3 ) 3 37.138 n-C 3 H 7 H Ph CH 2 CH=CH 2 37.139 n-C 3 H 7 H Ph CH 2 C≡CH 37.140 n-C 3 H 7 H Ph PhCH 2 37.141 n-C 3 H 7 H Ph PhCH 2 CH 2 37.142 iso-C 3 H 7 H Ph C 2 H 5 37.143 iso-C 3 H 7 H Ph n-C 3 H 7 37.144 iso-C 3 H 7 H Ph iso-C 3 H 7 37.145 iso-C 3 H 7 H Ph n-C 4 H 9 37.146 iso-C 3 H 7 H Ph iso-C 4 H 9 37.147 iso-C 3 H 7 H Ph C(CH 3 ) 3 37.148 iso-C 3 H 7 H Ph CH 2 CH=CH 2 37.149 iso-C 3 H 7 H Ph CH 2 C≡CH 37.150 iso-C 3 H 7 H Ph PhCH 2 37.151 iso-C 3 H 7 H Ph PhCH 2 CH 2 37.152 cyclopropyl H Ph CH 3 37.153 cyclopropyl H 2-Cl(Ph) CH 3 37.154 cyclopropyl H 3-Cl(Ph) CH 3 37.155 cyclopropyl H 4-Cl(Ph) CH 3 37.156 cyclopropyl H 4-Br(Ph) CH 3 37.157 cyclopropyl H 4-F(Ph) CH 3 37.158 cyclopropyl H 4-OCH 3 (Ph) CH 3 37.159 cyclopropyl H 4-CH 3 (Ph) CH 3 37.160 cyclopropyl H 4-NO 2 (Ph) CH 3 37.161 cyclopropyl H 2,4-Cl(Ph) CH 3 37.162 cyclopropyl H 2,4-F(Ph) CH 3 37.163 cyclopropyl H 3,4-F(Ph) CH 3 37.164 Ph H Ph CH 3 37.165 Ph H 2-Cl(Ph) C 2 H 5 37.166 Ph H 3-Cl(Ph) n-C 3 H 7 37.167 Ph H 4-Cl(Ph) iso-C 3 H 7 37.168 Ph H 4-Br(Ph) n-C 4 H 9 37.169 Ph H 4-F(Ph) iso-C 4 H 9 37.170 Ph H 4-OCH 3 (Ph) C(CH 3 ) 3 37.171 Ph H 4-CH 3 (Ph) CH 2 CH=CH 2 37.172 Ph H 4-NO 2 (Ph) CH 2 C≡CH 37.173 Ph H 2,4-Cl(Ph) PhCH 2 37.174 CN H Ph CH 3 37.175 CN H 2-Cl(Ph) CH 3 37.176 CN H 3-Cl(Ph) CH 3 37.177 CN H 4-Cl(Ph) CH 3 37.178 CN H 4-Br(Ph) CH 3 37.179 CN H 4-F(Ph) CH 3 37.180 CN H 4-Cl(Ph) CH 3 37.181 CN H 4-Br(Ph) CH 3 37.182 CN H 4-F(Ph) CH 3 37.183 CN H 4-OCH 3 (Ph) CH 3 37.184 CN H 4-CH 3 (Ph) CH 3 37.185 CN H 4-NO 2 (Ph) CH 3 37.186 CN H 2,4-Cl(Ph) CH 3 37.187 CN H 2,4-F(Ph) CH 3 37.188 CN H 4-CF 3 (Ph) CH 3 37.189 CN H Ph C 2 H 5 37.190 CN H Ph n-C 3 H 7 37.191 CN H Ph iso-C 3 H 7 37.192 CN H Ph n-C 4 H 9 37.193 CN H Ph iso-C 4 H 9 37.194 CN H Ph C(CH 3 ) 3 37.195 CN H Ph CH 2 CH=CH 2 37.196 CN H Ph CH 2 C=CH 37.197 CN H Ph PhCH 2 37.198 CH 3 H 1-napthyl CH 3 37.199 CH 3 H 1-napthyl C 2 H 5 37.200 CH 3 H 1-napthyl n-C 3 H 7 37.201 CH 3 H 1-napthyl iso-C 3 H 7 37.202 CH 3 H 1-napthyl n-C 4 H 9 37.203 CH 3 H 1-napthyl iso-C 4 H 9 37.204 CH 3 H 1-napthyl C(CH 3 ) 3 37.205 CH 3 H 1-napthyl CH 2 CH=CH 2 37.206 CH 3 H 1-napthyl CH 2 C≡CH 37.207 CH 3 H 1-napthyl PhCH 2 37.208 CH 3 H 2-napthyl CH 3 37.209 CH 3 H 2-napthyl C 2 H 5 37.210 CH 3 H 2-napthyl n-C 3 H 7 37.211 CH 3 H 2-napthyl iso-C 3 H 7 37.212 CH 3 H 2-napthyl n-C 4 H 9 37.213 CH 3 H 2-napthyl iso-C 4 H 9 37.214 CH 3 H 2-napthyl C(CH 3 ) 3 37.215 CH 3 H 2-napthyl CH 2 CH=CH 2 37.216 CH 3 H 2-napthyl CH 2 C≡CH 37.217 CH 3 H 2-napthyl PhCH 2 37.218 CN H 1-napthyl CH 3 37.219 CN H 1-napthyl C 2 H 5 37.220 CN H 1-napthyl n-C 3 H 7 37.221 CN H 1-napthyl iso-C 3 H 7 37.222 CN H 1-napthyl n-C 4 H 9 37.223 CN H 1-napthyl iso-C 4 H 9 37.224 CN H 1-napthyl C(CH 3 ) 3 37.225 CN H 1-napthyl CH 2 CH=CH 2 37.226 CN H 1-napthyl CH 2 C≡CH 37.227 CN H 1-napthyl PhCH 2 37.228 CN H 2-napthyl CH 3 37.229 CN H 2-napthyl C 2 H 5 37.230 CN H 2-napthyl n-C 3 H 7 37.231 CN H 2-napthyl iso-C 3 H 7 37.232 CN H 2-napthyl n-C 4 H 9 37.233 CN H 2-napthyl iso-C 4 H 9 37.234 CN H 2-napthyl C(CH 3 ) 3 37.235 CN H 2-napthyl CH 2 CH=CH 2 37.236 CN H 2-napthyl CH 2 C≡CH 37.237 CN H 2-napthyl PhCH 2 37.238 CH 3 CH 3 1-napthyl CH 3 37.239 CH 3 CH 3 1-napthyl C 2 H 5 37.240 CH 3 CH 3 1-napthyl n-C 3 H 7 37.241 CH 3 CH 3 1-napthyl iso-C 3 H 7 37.242 CH 3 CH 3 1-napthyl n-C 4 H 9 37.243 CH 3 CH 3 1-napthyl iso-C 4 H 9 37.244 CH 3 CH 3 1-napthyl C(CH 3 ) 3 37.245 CH 3 CH 3 1-napthyl CH 2 CH=CH 2 37.246 CH 3 CH 3 1-napthyl CH 2 C=CH 37.247 CH 3 CH 3 1-napthyl PhCH 2 37.248 CH 3 CH 3 2-napthyl CH 3 37.249 CH 3 CH 3 2-napthyl C 2 H 5 37.250 CH 3 CH 3 2-napthyl n-C 3 H 7 37.251 CH 3 CH 3 2-napthyl iso-C 3 H 7 37.252 CH 3 CH 3 2-napthyl n-C 4 H 9 37.253 CH 3 CH 3 2-napthyl iso-C 4 H 9 37.254 CH 3 CH 3 2-napthyl C(CH 3 ) 3 37.255 CH 3 CH 3 2-napthyl CH 2 CH=CH 2 37.256 CH 3 CH 3 2-napthyl CH 2 C≡CH 37.257 CH 3 CH 3 2-napthyl PhCH 2 37.258 CN CH 3 1-napthyl CH 3 37.259 CN CH 3 1-napthyl C 2 H 5 37.260 CN CH 3 1-napthyl n-C 3 H 7 37.261 CN CH 3 1-napthyl iso-C 3 H 7 37.262 CN CH 3 1-napthyl n-C 4 H 9 37.263 CN CH 3 1-napthyl iso-C 4 H 9 37.264 CN CH 3 1-napthyl C(CH 3 ) 3 37.265 CN CH 3 1-napthyl CH 2 CH=CH 2 37.266 CN CH 3 1-napthyl CH 2 C≡CH 37.267 CN CH 3 1-napthyl PhCH 2 37.268 CN CH 3 2-napthyl CH 3 37.269 CN CH 3 2-napthyl C 2 H 5 37.270 CN CH 3 2-napthyl n-C 3 H 7 37.271 CN CH 3 2-napthyl iso-C 3 H 7 37.272 CN CH 3 2-napthyl n-C 4 H 9 Typical compounds encompassed by the present invention of Formula I include those compounds of Formula XI, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, Z=NR 10 , and where R 2 , R 3 , R 7 , and R 10 are defined in Table 38. Compd. R 2 R 3 R 7 R 10 38.1 H H Ph CH 3 38.2 H H 4-Cl(Ph) CH 3 38.3 H H 4-Br(Ph) CH 3 38.4 H H 4-F(Ph) CH 3 38.5 H H 4-OCH 3 (Ph) CH 3 38.6 H H 4-CF 3 (Ph) CH 3 38.7 H H Ph CH 3 38.8 H H 4-Cl(Ph) CH 3 38.9 H H 4-Br(Ph) CH 3 38.10 H H 4-F(Ph) CH 3 38.11 CH 3 H Ph CH 3 38.12 CH 3 H 2-Cl(Ph) CH 3 38.13 CH 3 H 3-Cl(Ph) CH 3 38.14 CH 3 H 4-Cl(Ph) CH 3 38.15 CH 3 H 2-Br(Ph) CH 3 38.16 CH 3 H 3-Br(Ph) CH 3 38.17 CH 3 H 4-Br(Ph) CH 3 38.18 CH 3 H Ph C 2 H 5 38.19 CH 3 H 2-Cl(Ph) C 2 H 5 38.20 CH 3 H 3-Cl(Ph) C 2 H 5 38.21 CH 3 H 4-Cl(Ph) C 2 H 5 38.22 CH 3 H 2-Br(Ph) C 2 H 5 38.23 CH 3 H 3-Br(Ph) C 2 H 5 38.24 CH 3 H 4-Br(Ph) C 2 H 5 38.25 CH 3 H 2-CH 3 (Ph) C 2 H 5 38.26 CH 3 H 3-CH 3 (Ph) C 2 H 5 38.27 CH 3 H 2-CF 3 (Ph) C 2 H 5 38.28 CH 3 H 3-CF 3 (Ph) C 2 H 5 38.29 CH 3 H 4-CF 3 (Ph) C 2 H 5 38.30 CH 3 H 2-NO 2 (Ph) C 2 H 5 38.31 CH 3 H 3-NO 2 (Ph) C 2 H 5 38.32 CH 3 H 4-NO 2 (Ph) C 2 H 5 38.33 CH 3 H 2,3-Cl(Ph) C 2 H 5 38.34 CH 3 H 2,4-Cl(Ph) C 2 H 5 38.35 CH 3 H 2,5-Cl(Ph) C 2 H 5 38.36 CH 3 H 2,6-Cl(Ph) C 2 H 5 38.37 CH 3 H 3,4-Cl(Ph) C 2 H 5 38.38 CH 3 H 3,5-Cl(Ph) C 2 H 5 38.39 CH 3 H Ph n-C 3 H 7 38.40 CH 3 H Ph iso-C 3 H 7 38.41 CH 3 H Ph n-C 4 H 9 38.42 CH 3 H Ph iso-C 4 H 9 38.43 CH 3 H Ph C(CH 3 ) 3 38.44 CH 3 H Ph CH 2 CH=CH 2 38.45 CH 3 H Ph CH 2 C≡CH 38.46 CH 3 H Ph PhCH 2 38.47 CH 3 CH 3 Ph CH 3 38.48 CH 3 CH 3 4-Cl(Ph) CH 3 38.49 CH 3 CH 3 4-Br(Ph) CH 3 38.50 CH 3 CH 3 4-F(Ph) CH 3 38.51 CH 3 CH 3 4-OCH 3 (Ph) CH 3 38.52 CH 3 CH 3 4-CH 3 (Ph) CH 3 38.53 CH 3 CH 3 4-NO 2 (Ph) CH 3 38.54 CH 3 CH 3 2,4-Cl(Ph) CH 3 38.55 CH 3 CH 3 2,4-F(Ph) CH 3 38.56 CH 3 CH 3 Ph C 2 H 5 38.57 CH 3 CH 3 2-Cl(Ph) C 2 H 5 38.58 CH 3 CH 3 3-Cl(Ph) C 2 H 5 38.59 CH 3 CH 3 4-Cl(Ph) C 2 H 5 38.60 CH 3 CH 3 4-F(Ph) C 2 H 5 38.61 CH 3 CH 3 3-OCH 3 (Ph) C 2 H 5 38.62 CH 3 CH 3 4-OCH 3 (Ph) C 2 H 5 38.63 CH 3 CH 3 4-CH 3 (Ph) C 2 H 5 38.64 CH 3 CH 3 4-NO 2 (Ph) C 2 H 5 38.65 CH 3 CH 3 2,4-Cl(Ph) C 2 H 5 38.66 CH 3 CH 3 2,4-F(Ph) C 2 H 5 38.67 CH 3 CH 3 Ph n-C 3 H 7 38.68 CH 3 CH 3 2-Cl(Ph) iso-C 3 H 7 38.69 CH 3 CH 3 3-Cl(Ph) n-C 4 H 9 38.70 CH 3 CH 3 4-Cl(Ph) iso-C 4 H 9 38.71 CH 3 CH 3 4-Br(Ph) sec-C 4 H 9 38.72 CH 3 CH 3 4-F(Ph) C(CH 3 ) 3 38.73 CH 3 CH 3 4-OCH 3 (Ph) CH 2 CH=CH 2 38.74 CH 3 CH 3 4-CH 3 (Ph) CH 2 C≡CH 38.75 CH 3 CH 3 4-NO 2 (Ph) PhCH 2 38.76 CH 3 CH 3 2,4-Cl(Ph) PhCH 2 CH 2 38.77 CH 3 CH 3 2,4-F(Ph) PhCH 2 CH 2 38.78 C 2 H 5 H Ph CH 3 38.79 C 2 H 5 H 2-Cl(Ph) CH 3 38.80 C 2 H 5 H 3-Cl(Ph) CH 3 38.81 C 2 H 5 H 4-Cl(Ph) CH 3 38.82 C 2 H 5 H 4-Br(Ph) CH 3 38.83 C 2 H 5 H 4-F(Ph) CH 3 38.84 C 2 H 5 H 4-OCH 3 (Ph) CH 3 38.85 C 2 H 5 H 4-CH 3 (Ph) CH 3 38.86 C 2 H 5 H 4-NO 2 (Ph) CH 3 38.87 C 2 H 5 H 2,4-Cl(Ph) CH 3 38.88 C 2 H 5 H 2,4-F(Ph) CH 3 38.89 C 2 H 5 H Ph C 2 H 5 38.90 C 2 H 5 H 2-Cl(Ph) C 2 H 5 38.91 C 2 H 5 H 3-Cl(Ph) C 2 H 5 38.92 C 2 H 5 H 4-Cl(Ph) C 2 H 5 38.93 C 2 H 5 H 4-F(Ph) C 2 H 5 38.94 C 2 H 5 H 3-OCH 3 (Ph) C 2 H 5 38.95 C 2 H 5 H 4-OCH 3 (Ph) C 2 H 5 38.96 C 2 H 5 H 4-CH 3 (Ph) C 2 H 5 38.97 C 2 H 5 H 4-NO 2 (Ph) C 2 H 5 38.98 C 2 H 5 H 2,4-Cl(Ph) C 2 H 5 38.99 C 2 H 5 H 2,4-F(Ph) C 2 H 5 38.100 C 2 H 5 H Ph n-C 3 H 7 38.101 C 2 H 5 H 2-Cl(Ph) iso-C 3 H 7 38.102 C 2 H 5 H 3-Cl(Ph) n-C 4 H 9 38.103 C 2 H 5 H 4-Cl(Ph) iso-C 4 H 9 38.104 C 2 H 5 H 4-F(Ph) sec-C 4 H 9 38.105 C 2 H 5 H 3-OCH 3 (Ph) C(CH 3 ) 3 38.106 C 2 H 5 H 4-OCH 3 (Ph) CH 2 CH=CH 2 38.107 C 2 H 5 H 4-CH 3 (Ph) CH 2 C≡CH 38.108 C 2 H 5 H 4-NO 2 (Ph) PhCH 2 38.109 C 2 H 5 H 2,4-Cl(Ph) PhCH 2 CH 2 38.110 C 2 H 5 H 2,4-F(Ph) CH 3 38.111 n-C 3 H 7 H Ph CH 3 38.112 n-C 3 H 7 H 2-Cl(Ph) CH 3 38.113 n-C 3 H 7 H 3-Cl(Ph) CH 3 38.114 n-C 3 H 7 H 4-Cl(Ph) CH 3 38.115 n-C 3 H 7 H 4-Br(Ph) CH 3 38.116 n-C 3 H 7 H 3-OCH 3 (Ph) CH 3 38.117 n-C 3 H 7 H 4-OCH 3 (Ph) CH 3 38.118 n-C 3 H 7 H 4-CH 3 (Ph) CH 3 38.119 n-C 3 H 7 H 4-NO 2 (Ph) CH 3 38.120 n-C 3 H 7 H 2,4-Cl(Ph) CH 3 38.121 n-C 3 H 7 H 2,4-F(Ph) CH 3 38.122 n-C 3 H 7 H Ph C 2 H 5 38.123 n-C 3 H 7 H 2-Cl(Ph) C 2 H 5 38.124 n-C 3 H 7 H 3-Cl(Ph) C 2 H 5 38.125 n-C 3 H 7 H 4-Cl(Ph) C 2 H 5 38.126 n-C 3 H 7 H 4-Br(Ph) C 2 H 5 38.127 n-C 3 H 7 H 4-F(Ph) C 2 H 5 38.128 n-C 3 H 7 H 4-OCH 3 (Ph) C 2 H 5 38.129 n-C 3 H 7 H 4-CH 3 (Ph) C 2 H 5 38.130 n-C 3 H 7 H 4-NO 2 (Ph) C 2 H 5 38.131 n-C 3 H 7 H 2,4-Cl(Ph) C 2 H 5 38.132 n-C 3 H 7 H 2,4-F(Ph) C 2 H 5 38.133 n-C 3 H 7 H Ph n-C 3 H 7 38.134 n-C 3 H 7 H Ph iso-C 3 H 7 38.135 n-C 3 H 7 H Ph n-C 4 H 9 38.136 n-C 3 H 7 H Ph iso-C 4 H 9 38.137 n-C 3 H 7 H Ph C(CH 3 ) 3 38.138 n-C 3 H 7 H Ph CH 2 CH=CH 2 38.139 n-C 3 H 7 H Ph CH 2 C≡CH 38.140 n-C 3 H 7 H Ph PhCH 2 38.141 n-C 3 H 7 H Ph PhCH 2 CH 2 38.142 iso-C 3 H 7 H Ph C 2 H 5 38.143 iso-C 3 H 7 H Ph n-C 3 H 7 38.144 iso-C 3 H 7 H Ph iso-C 3 H 7 38.145 iso-C 3 H 7 H Ph n-C 4 H 9 38.146 iso-C 3 H 7 H Ph iso-C 4 H 9 38.147 iso-C 3 H 7 H Ph C(CH 3 ) 3 38.148 iso-C 3 H 7 H Ph CH 2 CH=CH 2 38.149 iso-C 3 H 7 H Ph CH 2 C≡CH 38.150 iso-C 3 H 7 H Ph PhCH 2 38.151 iso-C 3 H 7 H Ph PhCH 2 CH 2 38.152 cyclopropyl H 4-F(Ph) CH 3 38.153 cyclopropyl H 4-OCH 3 (Ph) CH 3 38.154 cyclopropyl H 4-CH 3 (Ph) CH 3 38.155 cyclopropyl H 4-NO 2 (Ph) CH 3 38.156 cyclopropyl H 2,4-Cl(Ph) CH 3 38.157 cyclopropyl H 2,4-F(Ph) CH 3 38.158 cyclopropyl H 4-Cl(Ph) CH 3 38.159 cyclopropyl H 4-Br(Ph) CH 3 38.160 cyclopropyl H 4-F(Ph) CH 3 38.161 cyclopropyl H 4-OCH 3 (Ph) CH 3 38.162 cyclopropyl H 4-CH 3 (Ph) CH 3 38.163 cyclopropyl H 4-NO 2 (Ph) CH 3 38.164 Ph H Ph CH 3 38.165 Ph H 2-Cl(Ph) C 2 H 5 38.166 Ph H 3-Cl(Ph) n-C 3 H 7 38.167 Ph H 4-Cl(Ph) iso-C 3 H 7 38.168 Ph H 4-Br(Ph) n-C 4 H 9 38.169 Ph H 4-F(Ph) iso-C 4 H 9 38.170 Ph H 4-OCH 3 (Ph) C(CH 3 ) 3 38.171 Ph H 4-CH 3 (Ph) CH 2 CH=CH 2 38.172 Ph H 4-NO 2 (Ph) CH 2 C≡CH 38.173 Ph H 2,4-Cl(Ph) PhCH 2 38.174 CN H Ph CH 3 38.175 CN H 2-Cl(Ph) CH 3 38.176 CN H 3-Cl(Ph) CH 3 38.177 CN H 4-Cl(Ph) CH 3 38.178 CN H 4-Br(Ph) CH 3 38.179 CN H 4-F(Ph) CH 3 38.180 CN H 4-Cl(Ph) CH 3 38.181 CN H 4-Br(Ph) CH 3 38.182 CN H 4-F(Ph) CH 3 38.183 CN H 4-OCH 3 (Ph) CH 3 38.184 CN H 4-CH 3 (Ph) CH 3 38.185 CN H 4-NO 2 (Ph) CH 3 38.186 CN H 2,4-Cl(Ph) CH 3 38.187 CN H 2,4-F(Ph) CH 3 38.188 CN H 4-CF 3 (Ph) CH 3 38.189 CN H Ph C 2 H 5 38.190 CN H Ph n-C 3 H 7 38.191 CN H Ph iso-C 3 H 7 38.192 CN H Ph n-C 4 H 9 38.193 CN H Ph iso-C 4 H 9 38.194 CN H Ph C(CH 3 ) 3 38.195 CN H Ph CH 2 CH=CH 2 38.196 CN H Ph CH 2 C≡CH 38.197 CN H Ph PhCH 2 38.198 CH 3 H 1-napthyl CH 3 38.199 CH 3 H 1-napthyl C 2 H 5 38.200 CH 3 H 1-napthyl n-C 3 H 7 38.201 CH 3 H 1-napthyl iso-C 3 H 7 38.202 CH 3 H 1-napthyl n-C 4 H 9 38.203 CH 3 H 1-napthyl iso-C 4 H 9 38.204 CH 3 H 1-napthyl C(CH 3 ) 3 38.205 CH 3 H 1-napthyl CH 2 CH=CH 2 38.206 CH 3 H 1-napthyl CH 2 C≡CH 38.207 CH 3 H 1-napthyl PhCH 2 38.208 CH 3 H 2-napthyl CH 3 38.209 CH 3 H 2-napthyl C 2 H 5 38.210 CH 3 H 2-napthyl n-C 3 H 7 38.211 CH 3 H 2-napthyl iso-C 3 H 7 38.212 CH 3 H 2-napthyl n-C 4 H 9 38.213 CH 3 H 2-napthyl iso-C 4 H 9 38.214 CH 3 H 2-napthyl C(CH 3 ) 3 38.215 CH 3 H 2-napthyl CH 2 CH=CH 2 38.216 CH 3 H 2-napthyl CH 2 C≡CH 38.217 CH 3 H 2-napthyl PhCH 2 38.218 CN H 1-napthyl CH 3 38.219 CN H 1-napthyl C 2 H 5 38.220 CN H 1-napthyl n-C 3 H 7 38.221 CN H 1-napthyl iso-C 3 H 7 38.222 CN H 1-napthyl n-C 4 H 9 38.223 CN H 1-napthyl iso-C 4 H 9 38.224 CN H 1-napthyl C(CH 3 ) 3 38.225 CN H 1-napthyl CH 2 CH=CH 2 38.226 CN H 1-napthyl CH 2 C≡CH 38.227 CN H 1-napthyl PhCH 2 38.228 CN H 2-napthyl CH 3 38.229 CN H 2-napthyl C 2 H 5 38.230 CN H 2-napthyl n-C 3 H 7 38.231 CN H 2-napthyl iso-C 3 H 7 38.232 CN H 2-napthyl n-C 4 H 9 38.233 CN H 2-napthyl iso-C 4 H 9 38.234 CN H 2-napthyl C(CH 3 ) 3 38.235 CN H 2-napthyl CH 2 CH=CH 2 38.236 CN H 2-napthyl CH 2 C≡CH 38.237 CN H 2-napthyl PhCH 2 38.238 CH 3 CH 3 1-napthyl CH 3 38.239 CH 3 CH 3 1-napthyl C 2 H 5 38.240 CH 3 CH 3 1-napthyl n-C 3 H 7 38.241 CH 3 CH 3 1-napthyl iso-C 3 H 7 38.242 CH 3 CH 3 1-napthyl n-C 4 H 9 38.243 CH 3 CH 3 1-napthyl iso-C 4 H 9 38.244 CH 3 CH 3 1-napthyl C(CH 3 ) 3 38.245 CH 3 CH 3 1-napthyl CH 2 CH=CH 2 38.246 CH 3 CH 3 1-napthyl CH 2 C=CH 38.247 CH 3 CH 3 1-napthyl PhCH 2 38.248 CH 3 CH 3 2-napthyl CH 3 38.249 CH 3 CH 3 2-napthyl C 2 H 5 38.250 CH 3 CH 3 2-napthyl n-C 3 H 7 38.251 CH 3 CH 3 2-napthyl iso-C 3 H 7 38.252 CH 3 CH 3 2-napthyl n-C 4 H 9 38.253 CH 3 CH 3 2-napthyl iso-C 4 H 9 38.254 CH 3 CH 3 2-napthyl C(CH 3 ) 3 38.255 CH 3 CH 3 2-napthyl CH 2 CH=CH 2 38.256 CH 3 CH 3 2-napthyl CH 2 C≡CH 38.257 CH 3 CH 3 2-napthyl PhCH 2 38.258 CN CH 3 1-napthyl CH 3 38.259 CN CH 3 1-napthyl C 2 H 5 38.260 CN CH 3 1-napthyl n-C 3 H 7 38.261 CN CH 3 1-napthyl iso-C 3 H 7 38.262 CN CH 3 1-napthyl n-C 4 H 9 38.263 CN CH 3 1-napthyl iso-C 4 H 9 38.264 CN CH 3 1-napthyl C(CH 3 ) 3 38.265 CN CH 3 1-napthyl CH 2 CH=CH 2 38.266 CN CH 3 1-napthyl CH 2 C≡CH 38.267 CN CH 3 1-napthyl PhCH 2 38.268 CN CH 3 2-napthyl CH 3 38.269 CN CH 3 2-napthyl C 2 H 5 38.270 CN CH 3 2-napthyl n-C 3 H 7 38.271 CN CH 3 2-napthyl iso-C 3 H 7 38.272 CN CH 3 2-napthyl n-C 4 H 9 Typical compounds encompassed by the present invention of Formula I include those compounds of Formula XII, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, Z=NR 10 , and where R 2 , R 3 , R 7 , and R 10 are defined in Table 39. Compd. R 2 R 3 R 7 R 10 39.1 H H Ph CH 3 39.2 H H 4-Cl(Ph) CH 3 39.3 H H 4-Br(Ph) CH 3 39.4 H H 4-F(Ph) CH 3 39.5 H H 4-OCH 3 (Ph) CH 3 39.6 H H 4-CF 3 (Ph) CH 3 39.7 H H Ph CH 3 39.8 H H 4-Cl(Ph) CH 3 39.9 H H 4-Br(Ph) CH 3 39.10 H H 4-F(Ph) CH 3 39.11 CH 3 H Ph CH 3 39.12 CH 3 H 2-Cl(Ph) CH 3 39.13 CH 3 H 3-Cl(Ph) CH 3 39.14 CH 3 H 4-Cl(Ph) CH 3 39.15 CH 3 H 2-Br(Ph) CH 3 39.16 CH 3 H 3-Br(Ph) CH 3 39.17 CH 3 H 4-Br(Ph) CH 3 39.18 CH 3 H Ph C 2 H 5 39.19 CH 3 H 2-Cl(Ph) C 2 H 5 39.20 CH 3 H 3-Cl(Ph) C 2 H 5 39.21 CH 3 H 4-Cl(Ph) C 2 H 5 39.22 CH 3 H 2-Br(Ph) C 2 H 5 39.23 CH 3 H 3-Br(Ph) C 2 H 5 39.24 CH 3 H 4-Br(Ph) C 2 H 5 39.25 CH 3 H 2-CH 3 (Ph) C 2 H 5 39.26 CH 3 H 3-CH 3 (Ph) C 2 H 5 39.27 CH 3 H 2-CF 3 (Ph) C 2 H 5 39.28 CH 3 H 3-CF 3 (Ph) C 2 H 5 39.29 CH 3 H 4-CF 3 (Ph) C 2 H 5 39.30 CH 3 H 2-NO 2 (Ph) C 2 H 5 39.31 CH 3 H 3-NO 2 (Ph) C 2 H 5 39.32 CH 3 H 4-NO 2 (Ph) C 2 H 5 39.33 CH 3 H 2,3-Cl(Ph) C 2 H 5 39.34 CH 3 H 2,4-Cl(Ph) C 2 H 5 39.35 CH 3 H 2,5-Cl(Ph) C 2 H 5 39.36 CH 3 H 2,6-Cl(Ph) C 2 H 5 39.37 CH 3 H 3,4-Cl(Ph) C 2 H 5 39.38 CH 3 H 3,5-Cl(Ph) C 2 H 5 39.39 CH 3 H Ph n-C 3 H 7 39.40 CH 3 H Ph iso-C 3 H 7 39.41 CH 3 H Ph n-C 4 H 9 39.42 CH 3 H Ph iso-C 4 H 9 39.43 CH 3 H Ph C(CH 3 ) 3 39.44 CH 3 H Ph CH 2 CH=CH 2 39.45 CH 3 H Ph CH 2 C=CH 39.46 CH 3 H Ph PhCH 2 39.47 CH 3 CH 3 Ph CH 3 39.48 CH 3 CH 3 4-Cl(Ph) CH 3 39.49 CH 3 CH 3 4-Br(Ph) CH 3 39.50 CH 3 CH 3 4-F(Ph) CH 3 39.51 CH 3 CH 3 4-OCH 3 (Ph) CH 3 39.52 CH 3 CH 3 4-CH 3 (Ph) CH 3 39.53 CH 3 CH 3 4-NO 2 (Ph) CH 3 39.54 CH 3 CH 3 2,4-Cl(Ph) CH 3 39.55 CH 3 CH 3 2,4-F(Ph) CH 3 39.56 CH 3 CH 3 Ph C 2 H 5 39.57 CH 3 CH 3 2-Cl(Ph) C 2 H 5 39.58 CH 3 CH 3 3-Cl(Ph) C 2 H 5 39.59 CH 3 CH 3 4-Cl(Ph) C 2 H 5 39.60 CH 3 CH 3 4-F(Ph) C 2 H 5 39.61 CH 3 CH 3 3-OCH 3 (Ph) C 2 H 5 39.62 CH 3 CH 3 4-OCH 3 (Ph) C 2 H 5 39.63 CH 3 CH 3 4-CH 3 (Ph) C 2 H 5 39.64 CH 3 CH 3 4-NO 2 (Ph) C 2 H 5 39.65 CH 3 CH 3 2,4-Cl(Ph) C 2 H 5 39.66 CH 3 CH 3 2,4-F(Ph) C 2 H 5 39.67 CH 3 CH 3 Ph n-C 3 H 7 39.68 CH 3 CH 3 2-Cl(Ph) iso-C 3 H 7 39.69 CH 3 CH 3 3-Cl(Ph) n-C 4 H 9 39.70 CH 3 CH 3 4-Cl(Ph) iso-C 4 H 9 39.71 CH 3 CH 3 4-Br(Ph) sec-C 4 H 9 39.72 CH 3 CH 3 4-F(Ph) C(CH 3 ) 3 39.73 CH 3 CH 3 4-OCH 3 (Ph) CH 2 CH=CH 2 39.74 CH 3 CH 3 4-CH 3 (Ph) CH 2 C≡CH 39.75 CH 3 CH 3 4-NO 2 (Ph) PhCH 2 39.76 CH 3 CH 3 2,4-Cl(Ph) PhCH 2 CH 2 39.77 CH 3 CH 3 2,4-F(Ph) PhCH 2 CH 2 39.78 C 2 H 5 H Ph CH 3 39.79 C 2 H 5 H 2-Cl(Ph) CH 3 39.80 C 2 H 5 H 3-Cl(Ph) CH 3 39.81 C 2 H 5 H 4-Cl(Ph) CH 3 39.82 C 2 H 5 H 4-Br(Ph) CH 3 39.83 C 2 H 5 H 4-F(Ph) CH 3 39.84 C 2 H 5 H 4-OCH 3 (Ph) CH 3 39.85 C 2 H 5 H 4-CH 3 (Ph) CH 3 39.86 C 2 H 5 H 4-NO 2 (Ph) CH 3 39.87 C 2 H 5 H 2,4-Cl(Ph) CH 3 39.88 C 2 H 5 H 2,4-F(Ph) CH 3 39.89 C 2 H 5 H Ph C 2 H 5 39.90 C 2 H 5 H 2-Cl(Ph) C 2 H 5 39.91 C 2 H 5 H 3-Cl(Ph) C 2 H 5 39.92 C 2 H 5 H 4-Cl(Ph) C 2 H 5 39.93 C 2 H 5 H 4-F(Ph) C 2 H 5 39.94 C 2 H 5 H 3-OCH 3 (Ph) C 2 H 5 39.95 C 2 H 5 H 4-OCH 3 (Ph) C 2 H 5 39.96 C 2 H 5 H 4-CH 3 (Ph) C 2 H 5 39.97 C 2 H 5 H 4-NO 2 (Ph) C 2 H 5 39.98 C 2 H 5 H 2,4-Cl(Ph) C 2 H 5 39.99 C 2 H 5 H 2,4-F(Ph) C 2 H 5 39.100 C 2 H 5 H Ph n-C 3 H 7 39.101 C 2 H 5 H 2-Cl(Ph) iso-C 3 H 7 39.102 C 2 H 5 H 3-Cl(Ph) n-C 4 H 9 39.103 C 2 H 5 H 4-Cl(Ph) iso-C 4 H 9 39.104 C 2 H 5 H 4-F(Ph) sec-C 4 H 9 39.105 C 2 H 5 H 3-OCH 3 (Ph) C(CH 3 ) 3 39.106 C 2 H 5 H 4-OCH 3 (Ph) CH 2 CH=CH 2 39.107 C 2 H 5 H 4-CH 3 (Ph) CH 2 C≡CH 39.108 C 2 H 5 H 4-NO 2 (Ph) PhCH 2 39.109 C 2 H 5 H 2,4-Cl(Ph) PhCH 2 CH 2 39.110 C 2 H 5 H 2,4-F(Ph) CH 3 39.111 n-C 3 H 7 H Ph CH 3 39.112 n-C 3 H 7 H 2-Cl(Ph) CH 3 39.113 n-C 3 H 7 H 3-Cl(Ph) CH 3 39.114 n-C 3 H 7 H 4-Cl(Ph) CH 3 39.115 n-C 3 H 7 H 4-Br(Ph) CH 3 39.116 n-C 3 H 7 H 3-OCH 3 (Ph) CH 3 39.117 n-C 3 H 7 H 4-OCH 3 (Ph) CH 3 39.118 n-C 3 H 7 H 4-CH 3 (Ph) CH 3 39.119 n-C 3 H 7 H 4-NO 2 (Ph) CH 3 39.120 n-C 3 H 7 H 2,4-Cl(Ph) CH 3 39.121 n-C 3 H 7 H 2,4-F(Ph) CH 3 39.122 n-C 3 H 7 H Ph C 2 H 5 39.123 n-C 3 H 7 H 2-Cl(Ph) C 2 H 5 39.124 n-C 3 H 7 H 3-Cl(Ph) C 2 H 5 39.125 n-C 3 H 7 H 4-Cl(Ph) C 2 H 5 39.126 n-C 3 H 7 H 4-Br(Ph) C 2 H 5 39.127 n-C 3 H 7 H 4-F(Ph) C 2 H 5 39.128 n-C 3 H 7 H 4-OCH 3 (Ph) C 2 H 5 39.129 n-C 3 H 7 H 4-CH 3 (Ph) C 2 H 5 39.130 n-C 3 H 7 H 4-NO 2 (Ph), C 2 H 5 39.131 n-C 3 H 7 H 2,4-Cl(Ph) C 2 H 5 39.132 n-C 3 H 7 H 2,4-F(Ph) C 2 H 5 39.133 n-C 3 H 7 H Ph n-C 3 H 7 39.134 n-C 3 H 7 H Ph iso-C 3 H 7 39.135 n-C 3 H 7 H Ph n-C 4 H 9 39.136 n-C 3 H 7 H Ph iso-C 4 H 9 39.137 n-C 3 H 7 H Ph C(CH 3 ) 3 39.138 n-C 3 H 7 H Ph CH 2 CH=CH 2 39.139 n-C 3 H 7 H Ph CH 2 C≡CH 39.140 n-C 3 H 7 H Ph PhCH 2 39.141 n-C 3 H 7 H Ph PhCH 2 CH 2 39.142 iso-C 3 H 7 H Ph C 2 H 5 39.143 iso-C 3 H 7 H Ph n-C 3 H 7 39.144 iso-C 3 H 7 H Ph iso-C 3 H 7 39.145 iso-C 3 H 7 H Ph n-C 4 H 9 39.146 iso-C 3 H 7 H Ph iso-C 4 H 9 39.147 iso-C 3 H 7 H Ph C(CH 3 ) 3 39.148 iso-C 3 H 7 H Ph CH 2 CH=CH 2 39.149 iso-C 3 H 7 H Ph CH 2 C≡CH 39.150 iso-C 3 H 7 H Ph PhCH 2 39.151 iso-C 3 H 7 H Ph PhCH 2 CH 2 39.152 cyclopropyl H 4-F(Ph) CH 3 39.153 cyclopropyl H 4-OCH 3 (Ph) CH 3 39.154 cyclopropyl H 4-CH 3 (Ph) CH 3 39.155 cyclopropyl H 4-NO 2 (Ph) CH 3 39.156 cyclopropyl H 2,4-Cl(Ph) CH 3 39.157 cyclopropyl H 2,4-F(Ph) CH 3 39.158 cyclopropyl H 4-Cl(Ph) CH 3 39.159 cyclopropyl H 4-Br(Ph) CH 3 39.160 cyclopropyl H 4-F(Ph) CH 3 39.161 cyclopropyl H 4-OCH 3 (Ph) CH 3 39.162 cyclopropyl H 4-CH 3 (Ph) CH 3 39.163 cyclopropyl H 4-NO 2 (Ph) CH 3 39.164 Ph H Ph CH 3 39.165 Ph H 2-Cl(Ph) C 2 H 5 39.166 Ph H 3-Cl(Ph) n-C 3 H 7 39.167 Ph H 4-Cl(Ph) iso-C 3 H 7 39.168 Ph H 4-Br(Ph) n-C 4 H 9 39.169 Ph H 4-F(Ph) iso-C 4 H 9 39.170 Ph H 4-OCH 3 (Ph) C(CH 3 ) 3 39.171 Ph H 4-CH 3 (Ph) CH 2 CH=CH 2 39.172 Ph H 4-NO 2 (Ph) CH 2 C≡CH 39.173 Ph H 2,4-Cl(Ph) PhCH 2 39.174 CN H Ph CH 3 39.175 CN H 2-Cl(Ph) CH 3 39.176 CN H 3-Cl(Ph) CH 3 39.177 CN H 4-Cl(Ph) CH 3 39.178 CN H 4-Br(Ph) CH 3 39.179 CN H 4-F(Ph) CH 3 39.180 CN H 4-Cl(Ph) CH 3 39.181 CN H 4-Br(Ph) CH 3 39.182 CN H 4-F(Ph) CH 3 39.183 CN H 4-OCH 3 (Ph) CH 3 39.184 CN H 4-CH 3 (Ph) CH 3 39.185 CN H 4-NO 2 (Ph) CH 3 39.186 CN H 2,4-Cl(Ph) CH 3 39.187 CN H 2,4-F(Ph) CH 3 39.188 CN H 4-CF 3 (Ph) CH 3 39.189 CN H Ph C 2 H 5 39.190 CN H Ph n-C 3 H 7 39.191 CN H Ph iso-C 3 H 7 39.192 CN H Ph n-C 4 H 9 39.193 CN H Ph iso-C 4 H 9 39.194 CN H Ph C(CH 3 ) 3 39.195 CN H Ph CH 2 CH=CH 2 39.196 CN H Ph CH 2 C≡CH 39.197 CN H Ph PhCH 2 39.198 CH 3 H 1-napthyl CH 3 39.199 CH 3 H 1-napthyl C 2 H 5 39.200 CH 3 H 1-napthyl n-C 3 H 7 39.201 CH 3 H 1-napthyl iso-C 3 H 7 39.202 CH 3 H 1-napthyl n-C 4 H 9 39.203 CH 3 H 1-napthyl iso-C 4 H 9 39.204 CH 3 H 1-napthyl C(CH 3 ) 3 39.205 CH 3 H 1-napthyl CH 2 CH=CH 2 39.206 CH 3 H 1-napthyl CH 2 C≡CH 39.207 CH3 H 1-napthyl PhCH 2 39.208 CH 3 H 2-napthyl CH 3 39.209 CH 3 H 2-napthyl C 2 H 5 39.210 CH 3 H 2-napthyl n-C 3 H 7 39.211 CH 3 H 2-napthyl iso-C 3 H 7 39.212 CH 3 H 2-napthyl n-C 4 H 9 39.213 CH 3 H 2-napthyl iso-C 4 H 9 39.214 CH 3 H 2-napthyl C(CH 3 ) 3 39.215 CH 3 H 2-napthyl CH 2 CH=CH 2 39.216 CH 3 H 2-napthyl CH 2 C≡CH 39.217 CH 3 H 2-napthyl PhCH 2 39.218 CN H 1-napthyl CH 3 39.219 CN H 1-napthyl C 2 H 5 39.220 CN H 1-napthyl n-C 3 H 7 39.221 CN H 1-napthyl iso-C 3 H 7 39.222 CN H 1-napthyl n-C 4 H 9 39.223 CN H 1-napthyl iso-C 4 H 9 39.224 CN H 1-napthyl C(CH 3 ) 3 39.225 CN H 1-napthyl CH 2 CH=CH 2 39.226 CN H 1-napthyl CH 2 C≡CH 39.227 CN H 1-napthyl PhCH 2 39.228 CN H 2-napthyl CH 3 39.229 CN H 2-napthyl C 2 H 5 39.230 CN H 2-napthyl n-C 3 H 7 39.231 CN H 2-napthyl iso-C 3 H 7 39.232 CN H 2-napthyl n-C 4 H 9 39.233 CN H 2-napthyl iso-C 4 H 9 39.234 CN H 2-napthyl C(CH 3 ) 3 39.235 CN H 2-napthyl CH 2 CH=CH 2 39.236 CN H 2-napthyl CH 2 C≡CH 39.237 CN H 2-napthyl PhCH 2 39.238 CH 3 CH 3 1-napthyl CH 3 39.239 CH 3 CH 3 1-napthyl C 2 H 5 39.240 CH 3 CH 3 1-napthyl n-C 3 H 7 39.241 CH 3 CH 3 1-napthyl iso-C 3 H 7 39.242 CH 3 CH 3 1-napthyl n-C 4 H 9 39.243 CH 3 CH 3 1-napthyl iso-C 4 H 9 39.244 CH 3 CH 3 1-napthyl C(CH 3 ) 3 39.245 CH 3 CH 3 1-napthyl CH 2 CH=CH 2 39.246 CH 3 CH 3 1-napthyl CH 2 C≡CH 39.247 CH 3 CH 3 1-napthyl PhCH 2 39.248 CH 3 CH 3 2-napthyl CH 3 39.249 CH 3 CH 3 2-napthyl C 2 H 5 39.250 CH 3 CH 3 2-napthyl n-C 3 H 7 39.251 CH 3 CH 3 2-napthyl iso-C 3 H 7 39.252 CH 3 CH 3 2-napthyl n-C 4 H 9 39.253 CH 3 CH 3 2-napthyl iso-C 4 H 9 39.254 CH 3 CH 3 2-napthyl C(CH 3 ) 3 39.255 CH 3 CH 3 2-napthyl CH 2 CH=CH 2 39.256 CH 3 CH 3 2-napthyl CH 2 C≡CH 39.257 CH 3 CH 3 2-napthyl PhCH 2 39.258 CN CH 3 1-napthyl CH 3 39.259 CN CH 3 1-napthyl C 2 H 5 39.260 CN CH 3 1-napthyl n-C 3 H 7 39.261 CN CH 3 1-napthyl iso-C 3 H 7 39.262 CN CH 3 1-napthyl n-C 4 H 9 39.263 CN CH 3 1-napthyl iso-C 4 H 9 39.264 CN CH 3 1-napthyl C(CH 3 ) 3 39.265 CN CH 3 1-napthyl CH 2 CH=CH 2 39.266 CN CH 3 1-napthyl CH 2 C≡CH 39.267 CN CH 3 1-napthyl PhCH 2 39.268 CN CH 3 2-napthyl CH 3 39.269 CN CH 3 2-napthyl C 2 H 5 39.270 CN CH 3 2-napthyl n-C 3 H 7 39.271 CN CH 3 2-napthyl iso-C 3 H 7 39.272 CN CH 3 2-napthyl n-C 4 H 9 Table 40 Compounds 40.1 to 40.226 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, Z=NR 10 , where R 10 is CH 3 and the substituents R 2 , R 3 , and R 7 are defined in Table 4. Table 41 Compounds 41.1 to 41.226 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, Z=NR 10 , where R 10 is CH 3 and the substituents R 2 , R 3 , and R 7 are defined in Table 4. Table 42 Compounds 42.1 to 42.226 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, Z=NR 10 , where R 10 is CH 3 and the substituents R 2 , R 3 , and R 7 are defined in Table 4. Table 43 Compounds 43.1 to 43.221 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, Z=NR 10, where R 10 is C 2 H 5 and the substituents R 2 , R 3 , and R 7 are defined in Table 7. Table 44 Compounds 44.1 to 44.221 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, Z=NR 10 , where R 10 is C 2 H 5 and the substituents R 2 , R 3 , and R 7 are defined in Table 7. Table 45 Compounds 45.1 to 45.221 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, Z=NR 10 , where R 10 is C 2 H 5 and the substituents R 2 , R 3 , and R 7 are defined in Table 7. Table 46 Compounds 46.1 to 46.139 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, Z=NR 10 , where R 10 is Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 10. Table 47 Compounds 47.1 to 47.139 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, Z=NR 10 , where R 10 is Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 10. Table 48 Compounds 48.1 to 48.139 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, Z=NR 10 , where R 10 is Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 10. Typical compounds encompassed by the present invention of Formula I include those compounds of Formula X, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, Z=NR 10 , and where R 2 , R 3 , R 7 , R 10 , R 11 and R 12 are defined in Table 49. Compd . R 2 R 3 R 7 R 10 R 11 R 12 49.1 H H Ph N=CR 11 R 12 CH 3 CH 3 49.2 H H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.3 H H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 49.4 H H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 49.5 H H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 49.6 H H 4-CF 3 (Ph) N=CR 11 R 12 CH 3 CH 3 49.7 H H Ph N=CR 11 R 12 CH 3 CH 3 49.8 H H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.9 H H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 49.10 H H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 49.11 CH 3 H Ph N=CR 11 R 12 CH 3 CH 3 49.12 CH 3 H 2-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.13 CH 3 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.14 CH 3 H 4-Cl(Ph) N=OR 11 R 12 CH 3 CH 3 49.15 CH 3 H 2-Br(Ph) N=CR 11 R 12 CH 3 CH 3 49.16 CH 3 H 3-Br(Ph) N=CR 11 R 12 CH 3 CH 3 49.17 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 49.18 CH 3 H Ph N=CR 11 R 12 H Ph 49.19 CH 3 H 2-Cl(Ph) N=CR 11 R 12 H Ph 49.20 CH 3 H 3-Cl(Ph) N=CR 11 R 12 H Ph 49.21 CH 3 H 4-Cl(Ph) N=CR 11 R 12 H Ph 49.22 CH 3 H 2-Br(Ph) N=CR 11 R 12 H Ph 49.23 CH 3 H 3-Br(Ph) N=CR 11 R 12 H Ph 49.24 CH 3 H 4-Br(Ph) N=CR 11 R 12 H Ph 49.25 CH 3 H 2-CH 3 (Ph) N=CR 11 R 12 H Ph 49.26 CH 3 H 3-CH 3 (Ph) N=CR 11 R 12 H Ph 49.27 CH 3 H 2-CF 3 (Ph) N=CR 11 R 12 H Ph 49.28 CH 3 H 3-CF 3 (Ph) N=CR 11 R 12 H Ph 49.29 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 H Ph 49.30 CH 3 H 2-NO 2 (Ph) N=CR 11 R 12 H Ph 49.31 CH 3 H 3-NO 2 (Ph) N=CR 11 R 12 H Ph 49.32 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 H Ph 49.33 CH 3 H 2,3-Cl(Ph) N=CR 11 R 12 H Ph 49.34 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 H Ph 49.35 CH 3 H 2,5-Cl(Ph) N=CR 11 R 12 H Ph 49.36 CH 3 H 2,6-Cl(Ph) N=CR 11 R 12 H Ph 49.37 CH 3 H 3,4-Cl(Ph) N=CR 11 R 12 H Ph 49.38 CH 3 H 3,5-Cl(Ph) N=CR 11 R 12 H Ph 49.39 CH 3 H Ph N=CR 11 R 12 CH 3 Ph 49.40 CH 3 H 2-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.41 CH 3 H 3-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.42 CH 3 H 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.43 CH 3 H 2-Br(Ph) N=CR 11 R 12 CH 3 Ph 49.44 CH 3 H 3-Br(Ph) N=CR 11 R 12 CH 3 Ph 49.45 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 Ph 49.46 CH 3 H 2-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.47 CH 3 H 3-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.48 CH 3 H 2-CF 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.49 CH 3 H 3-CF 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.50 CH 3 H 4-F(Ph) N=CR 11 R 12 CH 3 Ph 49.51 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.52 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.53 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 49.54 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.55 CH 3 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 49.56 CH 3 H Ph N=CR 11 R 12 Ph Ph 49.57 CH 3 H 2-Cl(Ph) N=CR 11 R 12 Ph Ph 49.58 CH 3 H 3-Cl(Ph) N=CR 11 R 12 Ph Ph 49.59 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph Ph 49.60 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph Ph 49.61 CH 3 H 3-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 49.62 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 49.63 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph Ph 49.64 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph Ph 49.65 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph Ph 49.66 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph Ph 49.67 C 2 H 5 H Ph N=CR 11 R 12 CH 3 CH 3 49.68 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.69 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.70 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.71 C 2 H 5 H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 49.72 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 49.73 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 49.74 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 49.75 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 CH 3 49.76 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.77 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 CH 3 CH 3 49.78 C 2 H 5 H Ph N=CR 11 R 12 CH 3 CH 3 49.79 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 H Ph 49.80 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 H Ph 49.81 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 H Ph 49.82 C 2 H 5 H 4-Br(Ph) N=CR 11 R 12 H Ph 49.83 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 H Ph 49.84 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 H Ph 49.85 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 H Ph 49.86 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 H Ph 49.87 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 H Ph 49.88 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 H Ph 49.89 C 2 H 5 H Ph N=CR 11 R 12 CH 3 Ph 49.90 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.91 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.92 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.93 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 CH 3 Ph 49.94 C 2 H 5 H 3-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.95 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.96 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 49.97 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 49.98 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.99 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 49.100 C 2 H 5 H Ph N=CR 11 R 12 Ph Ph 49.101 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 Ph Ph 49.102 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 Ph Ph 49.103 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 Ph Ph 49.104 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 Ph Ph 49.105 C 2 H 5 H 3-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 49.106 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 49.107 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 Ph Ph 49.108 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 Ph Ph 49.109 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 Ph Ph 49.110 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 Ph Ph 49.111 iso-C 3 H 7 H Ph N=CR 11 R 12 CH 3 CH 3 49.112 iso-C 3 H 7 H 2-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.113 iso-C 3 H 7 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.114 iso-C 3 H 7 H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 49.115 iso-C 3 H 7 H 4-Br(Ph) N=CR 11 R 12 H Ph 49.116 iso-C 3 H 7 H 3-OCH 3 (Ph) N=CR 11 R 12 H Ph 49.117 iso-C 3 H 7 H 4-OCH 3 (Ph) N=CR 11 R 12 H Ph 49.118 iso-C 3 H 7 H 4-CH 3 (Ph) N=CR 11 R 12 H Ph 49.119 iso-C 3 H 7 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 49.120 iso-C 3 H 7 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.121 iso-C 3 H 7 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 49.122 cyclopropyl H Ph N=CR 11 R 12 Ph 4-Cl(Ph) 49.123 cyclopropyl H 2-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.124 cyclopropyl H 3-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.125 cyclopropyl H 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.126 cyclopropyl H 4-Br(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.127 cyclopropyl H 4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.128 cyclopropyl H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 49.129 cyclopropyl H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 49.130 cyclopropyl H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-pyridyl 49.131 cyclopropyl H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 49.132 cyclopropyl H 2,4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 49.133 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 49.134 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 49.135 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 49.136 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 49.137 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 CH 3 49.138 CH 3 H 1-napthyl N-CR 11 R 12 H Ph 49.139 C 2 H 5 H 1-napthyl N=CR 11 R 12 H Ph 49.140 n-C 3 H 7 H 1-napthyl N-OR 11 R 12 H Ph 49.141 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 H Ph 49.142 cyclopropyl H 1-napthyl N=CR 11 R 12 H Ph 49.143 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 Ph 49.144 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 Ph 49.145 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 Ph 49.146 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 Ph 49.147 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 Ph 49.148 CH 3 H 1-napthyl N=CR 11 R 12 Ph Ph 49.149 C 2 H 5 H 1-napthyl N=CR 11 R 12 Ph Ph 49.150 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 Ph Ph 49.151 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 Ph Ph 49.152 cyclopropyl H 1-napthyl N=CR 11 R 12 Ph Ph 49.153 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 49.154 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 49.155 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 49.156 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 49.157 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 CH 3 49.158 CH 3 H 2-napthyl N=CR 11 R 12 H Ph 49.159 C 2 H 5 H 2-napthyl N=CR 11 R 12 H Ph 49.160 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 H Ph 49.161 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 H Ph 49.162 cyclopropyl H 2-napthyl N=CR 11 R 12 H Ph 49.163 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 Ph 49.164 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 Ph 49.165 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 Ph 49.166 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 Ph 49.167 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 Ph 49.168 CH 3 H 2-napthyl N=CR 11 R 12 Ph Ph 49.169 C 2 H 5 H 2-napthyl N=CR 11 R 12 Ph Ph 49.170 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 Ph Ph 49.171 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 Ph Ph 49.172 cyclopropyl H 2-napthyl N=CR 11 R 12 Ph Ph 49.173 CH 3 H Ph N=CR 11 R 12 Ph 4-Cl(Ph) 49.174 CH 3 H 2-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.175 CH 3 H 3-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.176 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.177 CH3 H 4-Br(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.178 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.179 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.180 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.181 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.182 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.183 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.184 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.185 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.186 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.187 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.188 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 49.189 CH 3 H Ph N=CR 11 R 12 Ph 4-pyridyl 49.190 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 49.191 CH 3 H 4-Br(Ph) N=CR 11 R 12 Ph 4-pyridyl 49.192 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 49.193 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 49.194 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 49.195 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-pyridyl 49.196 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 49.197 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 49.198 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 49.199 CH 3 H Ph N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.200 CH 3 H 4-Cl(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.201 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.202 CH 3 H 4-F(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.203 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.204 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 N(CH3) 2 49.205 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.206 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.207 CH 3 H 2,4-F(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.208 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.209 CH 3 H Ph N=cyclopentyl 49.210 CH 3 H 4-Cl(Ph) N=cyclopentyl 49.211 CH 3 H 4-Br(Ph) N=cyclopentyl 49.212 CH 3 H 4-F(Ph) N=cyclopentyl 49.213 CH 3 H 4-OCH 3 (Ph) N=cyclopentyl 49.214 CH 3 H 4-CH 3 (Ph) N=cyclopentyl 49.215 CH 3 H 4-NO 2 (Ph) N=cyclopentyl 49.216 CH 3 H 2,4-Cl(Ph) N=cyclopentyl 49.217 CH 3 H 2,4-F(Ph) N=cyclopentyl 49.218 CH 3 H 4-CF 3 (Ph) N=cyclopentyl 49.219 CH 3 H Ph N=cyclohexyl 49.220 CH 3 H 4-Cl(Ph) N=cyclohexyl 49.221 CH 3 H 4-Br(Ph) N=cyclohexyl 49.222 CH 3 H 4-F(Ph) N=cyclohexyl 49.223 CH 3 H 4-OCH 3 (Ph) N=cyclohexyl 49.224 CH 3 H 4-CH 3 (Ph) N=cyclohexyl 49.225 CH 3 H 4-NO 2 (Ph) N=cyclohexyl 49.226 CH 3 H 2,4-Cl(Ph) N=cyclohexyl 49.227 CH 3 H 2,4-F(Ph) N=cyclohexyl 49.228 CH 3 H 4-CF 3 (Ph) N=cyclohexyl 49.229 CH 3 H 1-napthyl N=cyclopentyl 49.230 C 2 H 5 H 1-napthyl N=cyclopentyl 49.231 n-C 3 H 7 H 1-napthyl N=cyclopentyl 49.232 iso-C 3 H 7 H 1-napthyl N=cyclopentyl 49.233 cyclopropyl H 1-napthyl N=cyclopentyl 49.234 CH 3 H 1-napthyl N=cyclohexyl 49.235 C 2 H 5 H 1-napthyl N=cyclohexyl 49.236 n-C 3 H 7 H 1-napthyl N=cyclohexyl 49.237 iso-C 3 H 7 H 1-napthyl N=cyclohexyl 49.238 cyclopropyl H 1-napthyl N=cyclohexyl 49.239 CH 3 H 2-napthyl N=cyclopentyl 49.240 C 2 H 5 H 2-napthyl N=cyclopentyl 49.241 n-C 3 H 7 H 2-napthyl N=cyclopentyl 49.242 iso-C 3 H 7 H 2-napthyl N=cyclopentyl 49.243 cyclopropyl H 2-napthyl N=cyclopentyl 49.244 CH 3 H 2-napthyl N=cyclohexyl 49.245 C 2 H 5 H 2-napthyl N=cyclohexyl 49.246 n-C 3 H 7 H 2-napthyl N=cyclohexyl 49.247 iso-C 3 H 7 H 2-napthyl N=cyclohexyl 49.248 cyclopropyl H 2-napthyl N=cyclohexyl 49.249 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.250 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.251 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.252 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.253 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.254 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.255 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.256 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.257 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.258 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 49.259 CH 3 CH 3 Ph N=CR 11 R 12 H Ph 49.260 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 H Ph 49.261 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 H Ph 49.262 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 H Ph 49.263 CH 3 CH 3 Ph N=CR 11 R 12 CH 3 Ph 49.264 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 49.265 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 CH 3 Ph 49.266 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 CH 3 Ph 49.267 CH 3 CH 3 Ph N=CR 11 R 12 Ph Ph 49.268 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 Ph Ph 49.269 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 Ph Ph 49.270 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 Ph Ph 49.271 CH 3 CH 3 Ph N=CR 11 R 12 Ph 4-Cl(Ph) 49.272 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) Typical compounds encompassed by the present invention of Formula I include those compounds of Formula XI, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, Z=NR 10 , and where R 2 , R 3 , R 7 , R 10 , R 11 and R 12 are defined in Table 50. Compd. R 2 R 3 R 7 R 10 R 11 R 12 50.1 H H Ph N=CR 11 R 12 CH 3 CH 3 50.2 H H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.3 H H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 50.4 H H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 50.5 H H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 50.6 H H 4-CF 3 (Ph) N=CR 11 R 12 CH 3 CH 3 50.7 H H Ph N=CR 11 R 12 CH 3 CH 3 50.8 H H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.9 H H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 50.10 H H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 50.11 CH 3 H Ph N=CR 11 R 12 CH 3 CH 3 50.12 CH 3 H 2-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.13 CH 3 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.14 CH 3 H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.15 CH 3 H 2-Br(Ph) N=CR 11 R 12 CH 3 CH 3 50.16 CH 3 H 3-Br(Ph) N=CR 11 R 12 CH 3 CH 3 50.17 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 50.18 CH 3 H Ph N=CR 11 R 12 H Ph 50.19 CH 3 H 2-Cl(Ph) N=CR 11 R 12 H Ph 50.20 CH 3 H 3-Cl(Ph) N=CR 11 R 12 H Ph 50.21 CH 3 H 4-Cl(Ph) N=CR 11 R 12 H Ph 50.22 CH 3 H 2-Br(Ph) N=CR 11 R 12 H Ph 50.23 CH 3 H 3-Br(Ph) N=CR 11 R 12 H Ph 50.24 CH 3 H 4-Br(Ph) N=CR 11 R 12 H Ph 50.25 CH 3 H 2-CH 3 (Ph) N=CR 11 R 12 H Ph 50.26 CH 3 H 3-CH 3 (Ph) N=CR 11 R 12 H Ph 50.27 CH 3 H 2-CF 3 (Ph) N=CR 11 R 12 H Ph 50.28 CH 3 H 3-CF 3 (Ph) N=CR 11 R 12 H Ph 50.29 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 H Ph 50.30 CH 3 H 2-NO 2 (Ph) N=CR 11 R 12 H Ph 50.31 CH 3 H 3-NO 2 (Ph) N=CR 11 R 12 H Ph 50.32 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 H Ph 50.33 CH 3 H 2,3-Cl(Ph) N=CR 11 R 12 H Ph 50.34 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 H Ph 50.35 CH 3 H 2,5-Cl(Ph) N=CR 11 R 12 H Ph 50.36 CH 3 H 2,6-Cl(Ph) N=CR 11 R 12 H Ph 50.37 CH 3 H 3,4-Cl(Ph) N=CR 11 R 12 H Ph 50.38 CH 3 H 3,5-Cl(Ph) N=CR 11 R 12 H Ph 50.39 CH 3 H Ph N=CR 11 R 12 CH 3 Ph 50.40 CH 3 H 2-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.41 CH 3 H 3-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.42 CH 3 H 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.43 CH 3 H 2-Br(Ph) N=CR 11 R 12 CH 3 Ph 50.44 CH 3 H 3-Br(Ph) N=CR 11 R 12 CH 3 Ph 50.45 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 Ph 50.46 CH 3 H 2-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.47 CH 3 H 3-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.48 CH 3 H 2-CF 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.49 CH 3 H 3-CF 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.50 CH 3 H 4-F(Ph) N=CR 11 R 12 CH 3 Ph 50.51 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.52 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.53 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 50.54 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.55 CH 3 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 50.56 CH 3 H Ph N=CR 11 R 12 Ph Ph 50.57 CH 3 H 2-Cl(Ph) N=CR 11 R 12 Ph Ph 50.58 CH 3 H 3-Cl(Ph) N=CR 11 R 12 Ph Ph 50.59 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph Ph 50.60 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph Ph 50.61 CH 3 H 3-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 50.62 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 50.63 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph Ph 50.64 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph Ph 50.65 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph Ph 50.66 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph Ph 50.67 C 2 H 5 H Ph N=CR 11 R 12 CH 3 CH 3 50.68 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.69 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.70 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.71 C 2 H 5 H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 50.72 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 50.73 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 50.74 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 50.75 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 CH 3 50.76 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.77 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 CH 3 CH 3 50.78 C 2 H 5 H Ph N=CR 11 R 12 CH 3 CH 3 50.79 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 H Ph 50.80 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 H Ph 50.81 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 H Ph 50.82 C 2 H 5 H 4-Br(Ph) N=CR 11 R 12 H Ph 50.83 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 H Ph 50.84 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 H Ph 50.85 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 H Ph 50.86 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 H Ph 50.87 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 H Ph 50.88 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 H Ph 50.89 C 2 H 5 H Ph N=CR 11 R 12 CH 3 Ph 50.90 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.91 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.92 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.93 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 CH 3 Ph 50.94 C 2 H 5 H 3-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.95 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.96 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 50.97 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 50.98 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.99 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 50.100 C 2 H 5 H Ph N=CR 11 R 12 Ph Ph 50.101 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 Ph Ph 50.102 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 Ph Ph 50.103 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 Ph Ph 50.104 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 Ph Ph 50.105 C 2 H 5 H 3-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 50.106 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 50.107 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 Ph Ph 50.108 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 Ph Ph 50.109 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 Ph Ph 50.110 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 Ph Ph 50.111 iso-C 3 H 7 H Ph N=CR 11 R 12 CH 3 CH 3 50.112 iso-C 3 H 7 H 2-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.113 iso-C 3 H 7 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.114 iso-C 3 H 7 H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 50.115 iso-C 3 H 7 H 4-Br(Ph) N=CR 11 R 12 H Ph 50.116 iso-C 3 H 7 H 3-OCH 3 (Ph) N=CR 11 R 12 H Ph 50.117 iso-C 3 H 7 H 4-OCH 3 (Ph) N=CR 11 R 12 H Ph 50.118 iso-C 3 H 7 H 4-CH 3 (Ph) N=CR 11 R 12 H Ph 50.119 iso-C 3 H 7 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 50.120 iso-C 3 H 7 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.121 iso-C 3 H 7 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 50.122 cyclopropyl H Ph N=CR 11 R 12 Ph 4-Cl(Ph) 50.123 cyclopropyl H 2-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.124 cyclopropyl H 3-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.125 cyclopropyl H 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.126 cyclopropyl H 4-Br(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.127 cyclopropyl H 4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.128 cyclopropyl H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 50.129 cyclopropyl H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 50.130 cyclopropyl H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-pyridyl 50.131 cyclopropyl H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 50.132 cyclopropyl H 2,4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 50.133 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 50.134 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 50.135 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 50.136 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 50.137 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 CH 3 50.138 CH 3 H 1-napthyl N=CR 11 R 12 H Ph 50.139 C 2 H 5 H 1-napthyl N=CR 11 R 12 H Ph 50.140 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 H Ph 50.141 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 H Ph 50.142 cyclopropyl H 1-napthyl N=CR 11 R 12 H Ph 50.143 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 Ph 50.144 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 Ph 50.145 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 Ph 50.146 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 Ph 50.147 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 Ph 50.148 CH 3 H 1-napthyl N=CR 11 R 12 Ph Ph 50.149 C 2 H 5 H 1-napthyl N=CR 11 R 12 Ph Ph 50.150 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 Ph Ph 50.151 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 Ph Ph 50.152 cyclopropyl H 1-napthyl N=CR 11 R 12 Ph Ph 50.153 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 50.154 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 50.155 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 50.156 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 50.157 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 CH 3 50.158 CH 3 H 2-napthyl N=CR 11 R 12 H Ph 50.159 C 2 H 5 H 2-napthyl N=CR 11 R 12 H Ph 50.160 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 H Ph 50.161 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 H Ph 50.162 cyclopropyl H 2-napthyl N=CR 11 R 12 H Ph 50.163 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 Ph 50.164 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 Ph 50.165 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 Ph 50.166 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 Ph 50.167 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 Ph 50.168 CH 3 H 2-napthyl N=CR 11 R 12 Ph Ph 50.169 C 2 H 5 H 2-napthyl N=CR 11 R 12 Ph Ph 50.170 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 Ph Ph 50.171 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 Ph Ph 50.172 cyclopropyl H 2-napthyl N=CR 11 R 12 Ph Ph 50.173 CH 3 H Ph N=CR 11 R 12 Ph 4-Cl(Ph) 50.174 CH 3 H 2-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.175 CH 3 H 3-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.176 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.177 CH 3 H 4-Br(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.178 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.179 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.180 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.181 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.182 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.183 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.184 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.185 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.186 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.187 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.188 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 50.189 CH 3 H Ph N=CR 11 R 12 Ph 4-pyridyl 50.190 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 50.191 CH 3 H 4-Br(Ph) N=CR 11 R 12 Ph 4-pyridyl 50.192 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 50.193 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 50.194 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 50.195 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-pyridyl 50.196 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 50.197 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 50.198 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 50.199 CH 3 H Ph N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.200 CH 3 H 4-Cl(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.201 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.202 CH 3 H 4-F(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.203 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.204 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.205 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 N(CH3)2 50.206 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.207 CH 3 H 2,4-F(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.208 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.209 CH 3 H Ph N=cyclopentyl 50.210 CH 3 H 4-Cl(Ph) N=cyclopentyl 50.211 CH 3 H 4-Br(Ph) N=cyclopentyl 50.212 CH 3 H 4-F(Ph) N=cyclopentyl 50.213 CH 3 H 4-OCH 3 (Ph) N=cyclopentyl 50.214 CH 3 H 4-CH 3 (Ph) N=cyclopentyl 50.215 CH 3 H 4-NO 2 (Ph) N=cyclopentyl 50.216 CH 3 H 2,4-Cl(Ph) N=cyclopentyl 50.217 CH 3 H 2,4-F(Ph) N=cyclopentyl 50.218 CH 3 H 4-CF 3 (Ph) N=cyclopentyl 50.219 CH 3 H Ph N=cyclohexyl 50.220 CH 3 H 4-Cl(Ph) N=cyclohexyl 50.221 CH 3 H 4-Br(Ph) N=cyclohexyl 50.222 CH 3 H 4-F(Ph) N=cyclohexyl 50.223 CH 3 H 4-OCH 3 (Ph) N=cyclohexyl 50.224 CH 3 H 4-CH 3 (Ph) N=cyclohexyl 50.225 CH 3 H 4-NO 2 (Ph) N=cyclohexyl 50.226 CH 3 H 2,4-Cl(Ph) N=cyclohexyl 50.227 CH 3 H 2,4-F(Ph) N=cyclohexyl 50.228 CH 3 H 4-CF 3 (Ph) N=cyclohexyl 50.229 CH 3 H 1-napthyl N=cyclopentyl 50.230 C 2 H 5 H 1-napthyl N=cyclopentyl 50.231 n-C 3 H 7 H 1-napthyl N=cyclopentyl 50.232 iso-C 3 H 7 H 1-napthyl N=cyclopentyl 50.233 cyclopropyl H 1-napthyl N=cyclopentyl 50.234 CH 3 H 1-napthyl N=cyclohexyl 50.235 C 2 H 5 H 1-napthyl N=cyclohexyl 50.236 n-C 3 H 7 H 1-napthyl N=cyclohexyl 50.237 iso-C 3 H 7 H 1-napthyl N=cyclohexyl 50.238 cyclopropyl H 1-napthyl N=cyclohexyl 50.239 CH 3 H 2-napthyl N=cyclopentyl 50.240 C 2 H 5 H 2-napthyl N=cyclopentyl 50.241 n-C 3 H 7 H 2-napthyl N=cyclopentyl 50.242 iso-C 3 H 7 H 2-napthyl N=cyclopentyl 50.243 cyclopropyl H 2-napthyl N=cyclopentyl 50.244 CH 3 H 2-napthyl N=cyclohexyl 50.245 C 2 H 5 H 2-napthyl N=cyclohexyl 50.246 n-C 3 H 7 H 2-napthyl N=cyclohexyl 50.247 iso-C 3 H 7 H 2-napthyl N=cyclohexyl 50.248 cyclopropyl H 2-napthyl N=cyclohexyl 50.249 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.250 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.251 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.252 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.253 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.254 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.255 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.256 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.257 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.258 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 50.259 CH 3 CH 3 Ph N=CR 11 R 12 H Ph 50.260 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 H Ph 50.261 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 H Ph 50.262 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 H Ph 50.263 CH 3 CH 3 Ph N=CR 11 R 12 CH 3 Ph 50.264 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 50.265 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 CH 3 Ph 50.266 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 CH 3 Ph 50.267 CH 3 CH 3 Ph N=CR 11 R 12 Ph Ph 50.268 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 Ph Ph 50.269 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 Ph Ph 50.270 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 Ph Ph 50.271 CH 3 CH 3 Ph N=CR 11 R 12 Ph 4-Cl(Ph) 50.272 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) Typical compounds encompassed by the present invention of Formula I include those compounds of Formula XII, which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, Z=NR 10 , and where R 2 , R 3 , R 7 , R 10 , R 11 and R 12 are defined in Table 51. Compd. R 2 R 3 R 7 R 10 R 11 R 12 51.1 H H Ph N=CR 11 R 12 CH 3 CH 3 51.2 H H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.3 H H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 51.4 H H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 51.5 H H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 51.6 H H 4-CF 3 (Ph) N=CR 11 R 12 CH 3 CH 3 51.7 H H Ph N=CR 11 R 12 CH 3 CH 3 51.8 H H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.9 H H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 51.10 H H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 51.11 CH 3 H Ph N=CR 11 R 12 CH 3 CH 3 51.12 CH 3 H 2-Cl(Ph) N-CR 11 R 12 CH 3 CH 3 51.13 CH 3 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.14 CH 3 H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.15 CH 3 H 2-Br(Ph) N=CR 11 R 12 CH 3 CH 3 51.16 CH 3 H 3-Br(Ph) N=CR 11 R 12 CH 3 CH 3 51.17 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 51.18 CH 3 H Ph N=CR 11 R 12 H Ph 51.19 CH 3 H 2-Cl(Ph) N=CR 11 R 12 H Ph 51.20 CH 3 H 3-Cl(Ph) N=CR 11 R 12 H Ph 51.21 CH 3 H 4-Cl(Ph) N=CR 11 R 12 H Ph 51.22 CH 3 H 2-Br(Ph) N=CR 11 R 12 H Ph 51.23 CH 3 H 3-Br(Ph) N=CR 11 R 12 H Ph 51.24 CH 3 H 4-Br(Ph) N=CR 11 R 12 H Ph 51.25 CH 3 H 2-CH 3 (Ph) N=CR 11 R 12 H Ph 51.26 CH 3 H 3-CH 3 (Ph) N=CR 11 R 12 H Ph 51.27 CH 3 H 2-CF 3 (Ph) N=CR 11 R 12 H Ph 51.28 CH 3 H 3-CF 3 (Ph) N=CR 11 R 12 H Ph 51.29 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 H Ph 51.30 CH 3 H 2-NO 2 (Ph) N=CR 11 R 12 H Ph 51.31 CH 3 H 3-NO 2 (Ph) N=CR 11 R 12 H Ph 51.32 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 H Ph 51.33 CH 3 H 2,3-Cl(Ph) N=CR 11 R 12 H Ph 51.34 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 H Ph 51.35 CH 3 H 2,5-Cl(Ph) N=CR 11 R 12 H Ph 51.36 CH 3 H 2,6-Cl(Ph) N=CR 11 R 12 H Ph 51.37 CH 3 H 3,4-Cl(Ph) N=CR 11 R 12 H Ph 51.38 CH 3 H 3,5-Cl(Ph) N=CR 11 R 12 H Ph 51.39 CH 3 H Ph N=CR 11 R 12 CH 3 Ph 51.40 CH 3 H 2-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.41 CH 3 H 3-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.42 CH 3 H 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.43 CH 3 H 2-Br(Ph) N=CR 11 R 12 CH 3 Ph 51.44 CH 3 H 3-Br(Ph) N=CR 11 R 12 CH 3 Ph 51.45 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 Ph 51.46 CH 3 H 2-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.47 CH 3 H 3-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.48 CH 3 H 2-CF 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.49 CH 3 H 3-CF 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.50 CH 3 H 4-F(Ph) N=CR 11 R 12 CH 3 Ph 51.51 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.52 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.53 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 51.54 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.55 CH 3 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 51.56 CH 3 H Ph N=CR 11 R 12 Ph Ph 51.57 CH 3 H 2-Cl(Ph) N=CR 11 R 12 Ph Ph 51.58 CH 3 H 3-Cl(Ph) N=CR 11 R 12 Ph Ph 51.59 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph Ph 51.60 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph Ph 51.61 CH 3 H 3-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 51.62 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 51.63 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph Ph 51.64 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph Ph 51.65 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph Ph 51.66 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph Ph 51.67 C 2 H 5 H Ph N=CR 11 R 12 CH 3 CH 3 51.68 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.69 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.70 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.71 C 2 H 5 H 4-Br(Ph) N=CR 11 R 12 CH 3 CH 3 51.72 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 CH 3 CH 3 51.73 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 51.74 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 CH 3 51.75 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 CH 3 51.76 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.77 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 CH 3 CH 3 51.78 C 2 H 5 H Ph N=CR 11 R 12 CH 3 CH 3 51.79 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 H Ph 51.80 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 H Ph 51.81 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 H Ph 51.82 C 2 H 5 H 4-Br(Ph) N=CR 11 R 12 H Ph 51.83 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 H Ph 51.84 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 H Ph 51.85 C 2 H 5 H 4-CH 3 (Ph) N-CR 11 R 12 H Ph 51.86 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 H Ph 51.87 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 H Ph 51.88 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 H Ph 51.89 C 2 H 5 H Ph N=CR 11 R 12 CH 3 Ph 51.90 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.91 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.92 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.93 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 CH 3 Ph 51.94 C 2 H 5 H 3-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.95 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.96 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 Ph 51.97 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 51.98 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.99 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 51.100 C 2 H 5 H Ph N=CR 11 R 12 Ph Ph 51.101 C 2 H 5 H 2-Cl(Ph) N=CR 11 R 12 Ph Ph 51.102 C 2 H 5 H 3-Cl(Ph) N=CR 11 R 12 Ph Ph 51.103 C 2 H 5 H 4-Cl(Ph) N=CR 11 R 12 Ph Ph 51.104 C 2 H 5 H 4-F(Ph) N=CR 11 R 12 Ph Ph 51.105 C 2 H 5 H 3-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 51.106 C 2 H 5 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph Ph 51.107 C 2 H 5 H 4-CH 3 (Ph) N=CR 11 R 12 Ph Ph 51.108 C 2 H 5 H 4-NO 2 (Ph) N=CR 11 R 12 Ph Ph 51.109 C 2 H 5 H 2,4-Cl(Ph) N=CR 11 R 12 Ph Ph 51.110 C 2 H 5 H 2,4-F(Ph) N=CR 11 R 12 Ph Ph 51.111 iso-C 3 H 7 H Ph N=CR 11 R 12 CH 3 CH 3 51.112 iso-C 3 H 7 H 2-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.113 iso-C 3 H 7 H 3-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.114 iso-C 3 H 7 H 4-Cl(Ph) N=CR 11 R 12 CH 3 CH 3 51.115 iso-C 3 H 7 H 4-Br(Ph) N=CR 11 R 12 H Ph 51.116 iso-C 3 H 7 H 3-OCH 3 (Ph) N=CR 11 R 12 H Ph 51.117 iso-C 3 H 7 H 4-OCH 3 (Ph) N=CR 11 R 12 H Ph 51.118 iso-C 3 H 7 H 4-CH 3 (Ph) N=CR 11 R 12 H Ph 51.119 iso-C 3 H 7 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 Ph 51.120 iso-C 3 H 7 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.121 iso-C 3 H 7 H 2,4-F(Ph) N=CR 11 R 12 CH 3 Ph 51.122 cyclopropyl H Ph N=CR 11 R 12 Ph 4-Cl(Ph) 51.123 cyclopropyl H 2-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.124 cyclopropyl H 3-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.125 cyclopropyl H 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.126 cyclopropyl H 4-Br(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.127 cyclopropyl H 4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.128 cyclopropyl H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 51.129 cyclopropyl H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 51.130 cyclopropyl H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-pyridyl 51.131 cyclopropyl H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 51.132 cyclopropyl H 2,4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 51.133 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 51.134 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 51.135 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 51.136 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 CH 3 51.137 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 CH 3 51.138 CH 3 H 1-napthyl N=CR 11 R 12 H Ph 51.139 C 2 H 5 H 1-napthyl N=CR 11 R 12 H Ph 51.140 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 H Ph 51.141 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 H Ph 51.142 cyclopropyl H 1-napthyl N=CR 11 R 12 H Ph 51.143 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 Ph 51.144 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 Ph 51.145 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 Ph 51.146 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 Ph 51.147 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 Ph 51.148 CH 3 H 1-napthyl N=CR 11 R 12 Ph Ph 51.149 C 2 H 5 H 1-napthyl N=CR 11 R 12 Ph Ph 51.150 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 Ph Ph 51.151 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 Ph Ph 51.152 cyclopropyl H 1-napthyl N=CR 11 R 12 Ph Ph 51.153 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 51.154 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 51.155 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 51.156 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 CH 3 51.157 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 CH 3 51.158 CH 3 H 2-napthyl N=CR 11 R 12 H Ph 51.159 C 2 H 5 H 2-napthyl N=CR 11 R 12 H Ph 51.160 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 H Ph 51.161 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 H Ph 51.162 cyclopropyl H 2-napthyl N=CR 11 R 12 H Ph 51.163 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 Ph 51.164 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 Ph 51.165 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 Ph 51.166 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 Ph 51.167 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 Ph 51.168 CH 3 H 2-napthyl N=CR 11 R 12 Ph Ph 51.169 C 2 H 5 H 2-napthyl N=CR 11 R 12 Ph Ph 51.170 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 Ph Ph 51.171 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 Ph Ph 51.172 cyclopropyl H 2-napthyl N=CR 11 R 12 Ph Ph 51.173 CH 3 H Ph N=CR 11 R 12 Ph 4-Cl(Ph) 51.174 CH 3 H 2-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.175 CH 3 H 3-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.176 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.177 CH 3 H 4-Br(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.178 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.179 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.180 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.181 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.182 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.183 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.184 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.185 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.186 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.187 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.188 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 Ph 4-Cl(Ph) 51.189 CH 3 H Ph N=CR 11 R 12 Ph 4-pyridyl 51.190 CH 3 H 4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 51.191 CH 3 H 4-Br(Ph) N=CR 11 R 12 Ph 4-pyridyl 51.192 CH 3 H 4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 51.193 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 51.194 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 51.195 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 Ph 4-pyridyl 51.196 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 Ph 4-pyridyl 51.197 CH 3 H 2,4-F(Ph) N=CR 11 R 12 Ph 4-pyridyl 51.198 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 Ph 4-pyridyl 51.199 CH 3 H Ph N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.200 CH 3 H 4-Cl(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.201 CH 3 H 4-Br(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.202 CH 3 H 4-F(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.203 CH 3 H 4-OCH 3 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.204 CH 3 H 4-CH 3 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.205 CH 3 H 4-NO 2 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.206 CH 3 H 2,4-Cl(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.207 CH 3 H 2,4-F(Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.208 CH 3 H 4-CF 3 (Ph) N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.209 CH 3 H Ph N=cyclopentyl 51.210 CH 3 H 4-Cl(Ph) N=cyclopentyl 51.211 CH 3 H 4-Br(Ph) N=cyclopentyl 51.212 CH 3 H 4-F(Ph) N=cyclopentyl 51.213 CH 3 H 4-OCH 3 (Ph) N=cyclopentyl 51.214 CH 3 H 4-CH 3 (Ph) N=cyclopentyl 51.215 CH 3 H 4-NO 2 (Ph) N=cyclopentyl 51.216 CH 3 H 2,4-Cl(Ph) N=cyclopentyl 51.217 CH 3 H 2,4-F(Ph) N=cyclopentyl 51.218 CH 3 H 4-CF 3 (Ph) N=cyclopentyl 51.219 CH 3 H Ph N=cyclohexyl 51.220 CH 3 H 4-Cl(Ph) N=cyclohexyl 51.221 CH 3 H 4-Br(Ph) N=cyclohexyl 51.222 CH 3 H 4-F(Ph) N=cyclohexyl 51.223 CH 3 H 4-OCH 3 (Ph) N=cyclohexyl 51.224 CH 3 H 4-CH 3 (Ph) N=cyclohexyl 51.225 CH 3 H 4-NO 2 (Ph) N=cyclohexyl 51.226 CH 3 H 2,4-Cl(Ph) N=cyclohexyl 51.227 CH 3 H 2,4-F(Ph) N=cyclohexyl 51.228 CH 3 H 4-CF 3 (Ph) N=cyclohexyl 51.229 CH 3 H 1-napthyl N=cyclopentyl 51.230 C 2 H 5 H 1-napthyl N=cyclopentyl 51.231 n-C 3 H 7 H 1-napthyl N=cyclopentyl 51.232 iso-C 3 H 7 H 1-napthyl N=cyclopentyl 51.233 cyclopropyl H 1-napthyl N=cyclopentyl 51.234 CH 3 H 1-napthyl N=cyclohexyl 51.235 C 2 H 5 H 1-napthyl N=cyclohexyl 51.236 n-C 3 H 7 H 1-napthyl N=cyclohexyl 51.237 iso-C 3 H 7 H 1-napthyl N=cyclohexyl 51.238 cyclopropyl H 1-napthyl N=cyclohexyl 51.239 CH 3 H 2-napthyl N=cyclopentyl 51.240 C 2 H 5 H 2-napthyl N=cyclopentyl 51.241 n-C 3 H 7 H 2-napthyl N=cyclopentyl 51.242 iso-C 3 H 7 H 2-napthyl N=cyclopentyl 51.243 cyclopropyl H 2-napthyl N=cyclopentyl 51.244 CH 3 H 2-napthyl N=cyclohexyl 51.245 C 2 H 5 H 2-napthyl N=cyclohexyl 51.246 n-C 3 H 7 H 2-napthyl N=cyclohexyl 51.247 iso-C 3 H 7 H 2-napthyl N=cyclohexyl 51.248 cyclopropyl H 2-napthyl N=cyclohexyl 51.249 CH 3 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.250 C 2 H 5 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.251 n-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.252 iso-C 3 H 7 H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.253 cyclopropyl H 1-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.254 CH 3 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.255 C 2 H 5 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.256 n-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.257 iso-C 3 H 7 H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.258 cyclopropyl H 2-napthyl N=CR 11 R 12 CH 3 N(CH 3 ) 2 51.259 CH 3 CH 3 Ph N=CR 11 R 12 H Ph 51.260 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 H Ph 51.261 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 H Ph 51.262 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 H Ph 51.263 CH 3 CH 3 Ph N=CR 11 R 12 CH 3 Ph 51.264 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 CH 3 Ph 51.265 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 CH 3 Ph 51.266 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 CH 3 Ph 51.267 CH 3 CH 3 Ph N=CR 11 R 12 Ph Ph 51.268 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 Ph Ph 51.269 n-C 3 H 7 CH 3 4-Br(Ph) N=CR 11 R 12 Ph Ph 51.270 iso-C 3 H 7 CH 3 4-F(Ph) N=CR 11 R 12 Ph Ph 51.271 CH 3 CH 3 Ph N=CR 11 R 12 Ph 4-Cl(Ph) 51.272 C 2 H 5 CH 3 4-Cl(Ph) N=CR 11 R 12 Ph 4-Cl(Ph) Table 52: Compounds 52.1 to 52.226 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NR 10 , where R 10 is N=C(H)Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 4. Table 53: Compounds 53.1 to 53.226 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NR 10 , where R 10 is N=C(H)Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 4. Table 54: Compounds 54.1 to 54.226 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NR 10 , where R 10 is N=C(H)Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 4. Table 55: Compounds 55.1 to 55.221 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NR 10 , where Rio is N=C(CH 3 )Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 7. Table 56: Compounds 56.1 to 56.221 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NR 10 , where R 10 is N=C(CH 3 )Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 7. Table 57: Compounds 57.1 to 57.221 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NRio, where R 10 is N=C(CH 3 )Ph and the substituents R 2 , R 3 , and R 7 are defined in Table 7. Table 58: Compounds 58.1 to 58.139 are compounds of Formula X which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=CH, Y=O, and Z=NR 10 , where R 10 is N=CCPh 2 and the substituents R 2 , R 3 , and R 7 are defined in Table 7. Table 59: Compounds 59.1 to 59.139 are compounds of Formula XI which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=O, and Z=NR 10 , where R 10 is N=CCPh 2 and the substituents R 2 , R 3 , and R 7 are defined in Table 7. Table 60: Compounds 60.1 to 60.139 are compounds of Formula XII which is Formula I with A=R 4 =R 5 =R 6 =H, R 1 =CH 3 , X=N, Y=NH, and Z=NR 10 , where R 10 is N=C=CPh 2 and the substituents R 2 , R 3 , and R 7 are defined in Table 7. As used in Tables 1 to 60 Ph is understood to be phenyl. The preparation of certain bis-oximes is described in US5756426 and 5863951 and references cited therein. The specific methods for the preparation of cyclopropyl bis oximes of Formula I of the present invention are described in the following schemes. Scheme A describes the preparation of compounds of the Formula (I) where X is CHor N, and Y is O (compounds of formula XV and XVI). The cyclopropyl oximes (XIII) are reacted with the appropriately substituted benzyl derivatives (XIV) where L is a halogen, such as bromo, chloro or iodo, preferably a benzyl bromide. A cyclopropyl substituted oxime represented by the general formula (XIII) is treated, at room temperature, with an appropriate base to form an anion, followed by the addition of the benzyl bromides (XIV). Typical bases employed are metal hydrides such as sodium hydride, alkoxides such as sodium methoxide and hydroxide bases such as sodium or potassium hydroxide and alkali bases such as sodium or potassium carbonate. Typical solvents employed with hydride bases are N,N-dimethylformamide (DMF) and tetrahydrofuran (THF); with hydroxide bases DMF, THF, methyl ethyl ketone (MEK) and acetone and with alkali bases solvents such as DMF, acetone, and MEK. As shown in Scheme A, the N-O bond in C(R 2 )=N-O-and can exist as E and Z isomers. It should be recognized that the E and Z isomers can also be produced as well as mixtures. When isomers are produced they are designated isomer A (higher R f on thin layer chromatography) and isomer B (lower R f on thin layer chromatography). The determination of which isomer, A or B possesses the E or Z geometry can be made by such conventional techniques as X ray crystallography or by spectroscopic means such as nuclear magnetic resonance spectroscopy. The compounds of the of Formula I of the present invention have been produced as a single stereoisomer for the N-O bond in C(R2)=N-O- and has been assigned the E configuration by nuclear magnetic resonance spectroscopy. Additionally, compounds of Formula I can exist as isomers about the Z=C. It should be recognized that the regioisomers can also be produced as well as mixtures. When isomers are produced they are designated isomer A (higher R f on thin layer chromatography) and isomer B (lower R f on thin layer chromatography). The determination of which isomer, A or B possesses the E or Z geometry can be made by such conventional techniques as X ray crystallography or by spectroscopic means such as nuclear magnetic resonance spectroscopy.. When Z is NOR 9 the compounds designated as isomer A have the E geometry for R 9 ON=Cand compounds designated as isomer B have the Z geometry for R 9 ON=C. The compounds designated as A or B in the subsequent tables refer to the isomers of NOR 9 Compounds of formula XV (X is CH) are prepared by alkylation with methyl E-α-(2-bromomethylphenyl)-β-methoxyacrylate (XIV, where A=H, X=CH and L is Br) in the presence of a base, preferably NaOH or KOH, in a solvent, preferably acetone or methyl ethyl ketone. Methyl E-α-(2-bromomethylphenyl)-β-methoxyacrylate, as a single E isomer, can be prepared in two steps from 2-methylphenylacetate as described previously in US Patent Number 4,914,128 , columns 3-4. Compounds of formula XVI (X=N) are prepared by the reaction with methyl E-2-(bromomethyl)phenylglyoxylate O-methyloxime (XIV, where A=H, X=N and L is Br) in the presence of a base, preferably NaOH or KOH, in a solvent, preferably acetone or methyl ethyl ketone. Methyl 2-(bromomethyl)phenylglyoxylate O-methyloxime can be prepared as described in US Patent Numbers 4,999,042, columns 17-18 and 5,157,144, columns 17-18. Methyl 2-(bromomethyl)phenylglyoxylate O-methyl-oxime is prepared from methyl 2-methylphenyl-acetate by treatment with an alkyl nitrite under basic conditions to provide after methylation, methyl 2-methyl-phenyl-glyoxalate O-methyl oxime which can also be prepared from methyl 2-methyl-phenylglyoxalate by treatment with 2-hydroxylamine hydrochloride and methylation or by treatment with methoxylamine hydrochloride. As shown in scheme B compounds of formula XVIII (X=N, Y=NH) can be prepared by the aminolysis of oximinoacetate XVI. The aminolysis of oximinoacetate to oximinoacetamides has been described in US Patent Numbers 5,185,342, cols. 22, 48 and 57, 5,221,691, cols. 26-27 and 5,407,902 , col. 8. For example, compounds of Table 14 of formula VIII where X is N and Y is O are treated with 40% aqueous methylamine in methanol to provide compounds of Table 15 of formula IX where Y is NH. Alternatively, as is shown in scheme B intermediate cyclopropanes oximes, XIII, are reacted with N-methyl (E)-2-methoxyimino-2-[2-(bromomethyl)phenyl]-acetamide (XIV, where A=H and L=Br) in the presence of a base such as an hydroxide base preferably in a solvent such as acetone or methyl ethyl ketone to provide compounds of Table 15 of formula IX. N-methyl (E)-2-methoxy-imino-2-[2-(bromomethyl)phenyl]acetamide is described in US Patent Number 5,387,714, col. 14. The synthesis of compounds of formula I where Z is O is described in scheme C and follow the methods of schemes A and B. In scheme C the compounds of formula IV and V (A=H) can be prepared from oxime XIX by alkylation with XIV. Compounds of formula VI (A=H) can be prepared by alkylation of XIX with bromide XVII or by aminolysis of V as described in Scheme C. Compounds of Formula I where Z is NOR 9 (compounds of Formula VII, VIII, IX) can be prepared, as shown in scheme D, by condensation of compounds IV, V and VI with an hydroxylamine such as R 9 ONH 2 . The condensation can be carried out from room temperature to reflux, preferably at room temperature, in an appropriate solvent such as methanol or ethanol in the presence of an appropriate alkali such as sodium hydroxide, potassium carbonate or pyridine. Additionally, hydroxylamine hydrochloride can be utilized (R 9 is hydrogen) and the compounds VII', VIII' and IX' are obtained. Alkylation with R 9 -L where L is a leaving group such as Br or Cl provides VII, VIII and IX. The compounds of formula X,XI and XII where Z is N-R 10 , such as imines and hydrazones, are prepared as shown in scheme D by condensation of the ketones IV, V and VI, with an amine or hydrazine derivative. A general description of the synthesis of oximes with and imines is described in March, Advanced Organic Chemistry , 4th Ed, pp. 896-897, 904-907 and references therein. The oximes, imines, hydrazones of the general formula VII to XII when obtained as a mixture of syn or anti isomers can be separated into individual isomers by conventional chromatographic techniques. The isomer with the higher Rf on thin layer chromatography is designated isomer A and the isomer with the lower Rf on thin layer chromatography is designated isomer B. The stereochemistry of isomer A and B can be determined by standard techniques such as nuclear magnetic resonance spectroscopy. As is shown in scheme E the compounds of formula VII to XII can be prepared from the oxime intermediate XIX, by condensation methods described in Scheme D, leading to intermediate oximes XX and XXI. These oximes intermediates can be alkylated as described in schemes A,B and C to provide the products VII to XII. The oximes of the general formula XIX can be obtained as shown in scheme F. A general description of the synthesis of α-oximinoketones via nitrosation is described in March, Advanced Organic Chemistry , 4th Ed, pp. 592-593 and references therein. For the compounds of the present invention the cyclopropylketones, XXII are reacted with an alkyl nitrite such as t-butylnitrite or isoamylnitrite under basic conditions to provide the corresponding α-oximino cyclopropylketones XIX. This hydroxyimino intermediate, XIX, is typically produced as one major stereoisomer as shown in scheme F. Typically the cyclopropyl ketone in a solvent such as t-butanol and the alkyl nitrite, typically t-butylnitrite, is added to a solution t-butanol containing a base such as potassium t-butoxide and is stirred at room temperature. The α-hydroxyimino cyclopropylketones XIX are alkylated as in schemes C and E to provide compounds of the formula IV, V and VI. The cyclopropyl ketones XXII can be prepared by conventional techniques as is shown in scheme G. The unsaturated intermediate XXIII (scheme G) is reacted with a sulfur ylide, prepared from a dimethylsulfoxonium salt in the presence of a base, resulting in the substituted acyl cyclopropanes, XXII. The chemistry of sulfur ylides is described in Trost and Melvin, Sulfur Ylids , Academic Press, New York, NY 1975 and in Block, Reactions of Organosulfur Compounds , pp. 91-123, Academic Press, New York, NY 1978. Typical reaction conditions for sulfur ylide formation from a dimethylsulfoxonium salt utilizes bases such as hydroxides, metal hydrides and alkoxides in solvents such as dimethoxy-ethane, dimethylsulfoxide and water depending on the base employed. The reactions are conducted from 0 to 20°Cpreferably from 10-15°Cand preferably with alkali metal hydroxides in dimethylsulfoxide. Typically dimethylsulfoxonium methylide is prepared from trimethylsulfoxonium iodide in dimethylsulfoxide in the presence of powdered sodium hydroxide at room temperature. The unsaturated ketones, XXIII, are typically added drop wise to the ylide and stirred at room temperature. The α,β-unsaturated ketones XXIII can be prepared by conventional condensation techniques. A extensive description of the synthesis of α,β-unsaturated ketones (enones) is described in March, Advanced Organic Chemistry , 4th Ed, pp. 937-955 and references therein. For example Organic Reactions , Volume 16 describes the general aldol condensation of ketones and aldehydes. For intermediates of formula XXIII of this invention, in general the ketones can be R 7 COR 6 where R 7 and R 6 are defined previously. When R 6 is hydrogen the aldehydes are for example substituted benzaldehydes or heterocyclic aldehydes. The ketones can be R 2 CH 2 COCH 2 R 3 where R 2 and R 3 are described previously. Preferably for the enones derived via a condensation reaction R 3 is H and is therefore a methyl ketone. Likewise R 2 can be hydrogen which provides enones and cyclopropanes leading to the compounds of formula I where R 2 is hydrogen. Typically the ketone, R 2 CH 2 COCH 2 R 3 , is dissolved in a hydroxylic solvent, such as methanol or ethanol, to which is added drop wise the aldehyde or ketone R 7 COR 6 followed by the base or alternatively a solution of the aldehyde in an aqueous basic solution is added. The typical bases used can be alkali metal hydroxides, such as barium, potassium or sodium hydroxide and the drop wise addition is conducted from 0°Cto 35°Cpreferably at ambient temperature. When the enone is derived from a methylketone (R 3 is hydrogen) the solvent can be the methylketone to which is added R 7 COR 6 followed by the aqueous hydroxide solution. Alternatively the α,β-unsaturated cyclopropyl ketones XXII can be prepared from cyclopropyl nitriles XXV which are prepared via cyclopropanation of the acrylonitriles XXIV as is described in Scheme H. The acrylonitriles XXIV starting materials, shown in Scheme H can be prepared by conventional synthetic methods as described in March, Advanced Organic Chemistry, 4th Ed, pp. 937-955 and references therein . For example the nitrile derivative R 3 CH 2 CN is condensed with the ketone or aldehyde R 7 COR 6 , in the presence of a base to provide the acrylonitriles XXIV. Preferably R 3 in R 3 CH 2 CN is an aryl or heteroaryl group as defined previously for R 3 . Typically the nitrile is dissolved in a solvent such as ethanol and water to which is added the aldehyde or ketone followed by a base. Typical bases used can be alkali metal hydroxides, such as barium, potassium or sodium hydroxide and the mixture is stirred typically at ambient temperature. The acrylonitrile XXIV is treated as is described in Scheme H with a sulfur ylide to provide the cyclopropyl nitriles XXV. The cyclopropyl nitrile XXV is transformed to the cyclopropyl ketones by organometallic addition to the nitrile followed by hydrolysis. For example the standard Grignard reagents R 2 CH 2 MgX or organolithium reagents, R 2 CH 2 Li add to the nitrile functionality to provide the ketones XXII. The addition reaction to nitriles are described in March, Advanced Organic Chemistry, 4th Ed, pp.935-936 and references cited therein. When R 2 MgX is a methyl Grignard, such as methylmagnesium bromide the resulting methyl ketone. R 2 =H, provides compounds of the present invention where R 2 =H. The compounds of this invention can be made according to the following procedures: Example 1 Preparation of Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azahepta-3-en-1-yl)phenyl]propenoate Compound 1.11 of Table 1 Preparation of trans-1-phenyl-1-hexen-3-one To a 250 ml round bottom flask equipped with magnetic stirrer was charged 36 g (0.5 moles) of methylethyl ketone, 100 mls of ethanol, and 10 mls of water. To this solution was then added 0.5 g of barium hydroxide monohydrate, followed by 10.6 g (0.1 moles) of benzaldehyde. The flask was stoppered and stirred overnight at ambient temperature. The reaction mixture was then poured into 200 mls of water and extracted with 3 X 100 mls of ethyl ether. The ether extract was washed with 100 mls of saturated aqueous sodium bisulfite solution, followed by 100 mls of water, and 100 mls of saturated aqueous sodium chloride solution. The ether extract was then dried over anhydrous magnesium sulfate, filtered and concentrated on a rotary evaporator to afford 15.1 g of a pale yellow liquid in 94% isolated yield, which was consistent with the desired product trans-1-phenyl-1-hexen-3-one upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 1.17 (t, 3H), 2.7 (q, 2H), 6.7 (d, 1H), 7.4 (m, 3H), 7.6 (m, 3H) Preparation of trans-2-phenylcyclopropylethylketone To a 500 ml round bottom flask equipped with magnetic stirrer, nitrogen inlet, and pressure equalized addition funnel was charged 22 g (0.1 moles) of trimethylsulfoxonium iodide, 4.0 g (0.1 moles) of powdered sodium hydroxide, and 150 mls of dimethylsulfoxide. The solution was stirred at ambient temperature for 30 minutes, followed by the rapid addition of the trans-1-phenyl-1-hexen-3-one (15.1 g, 0.0945 moles) in 100 mls of dimethylsulfoxide. The reaction was then stirred for 10 minutes at ambient temperature, then poured into 200 mls of water and extracted with 3 x100 mls of ethyl ether. The ether extract was washed with 2 x 100 mls of water, and 100 mls of saturated aqueous sodium chloride solution. The ether extract was dried over anhydrous magnesium sulfate, filtered and concentrated on a rotary evaporator to afford 12.5 g of a thick yellow liquid which was purified by high vacuum distillation. (78-85 °C@ 0.1 mm Hg) The pure fractions were combined to afford 8.2 g of a clear colorless liquid in an 50% isolated yield which was consistent with the desired product, trans-2-phenylcyclopropylethylketone upon analysis by 300Mz 1 H NMR.. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 1.1 (t, 3H), 1.3 (m, 1H), 1.7 (m, 1H), 2.2 (m, 1H), 2.5 (m, 1H), 2.6 (q, 2H), 7.1 (d, 2H), 7.2-7.4 (m, 3H). Preparation of 2-hydroxyimino-1-(trans-2-phenylcyclopropyl)-1-propanone To a dry 500 ml round bottom flask equipped with magnetic stirrer, nitrogen inlet, reflux condenser, and side arm addition funnel was charged 5.7 g . (0.0505 moles) of potassium t-butoxide and 150 ml of t-butanol. When all of the solid was dissolved, the ketone trans-2-phenyl-cyclopropylethylketone (8.0 g, 0.0459 moles)was added in on portion, followed by the drop wise addition of 5.7 g (0.0505 moles) of 90% t-butyl nitrite. The reaction was stirred for 3 hours at ambient temperature then carefully quenched with 100 mls 0.1 N aqueous hydrochloric acid solution. The mixture was extracted with 3 x 100 mls of ethyl ether. The ether extract was then washed with 2 x 100 mls of water and 100 mls of saturated aqueous sodium chloride solution, then dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 8.2 g of a thick brown liquid which was crystallized from methylene chloride and hexane. The resulting solid was collected by vacuum filtration to afford 5.1 g of a tan solid in a 55% isolated yield which was consistent with the desired product as a single hydroxyimino isomer of 2-hydroxyimino-1-(trans-2-phenyl-cyclopropyl)-1-propanone upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 1.4 (m, 1H), 1.7 (m, 1H), 2.0 (s, 3H), 2.6 (m, 1H), 3.1 (m, 1H), 7.1 (d, 2H), 7.2-7.4 (m, 3H), 8.1 (bs, 1H). Preparation of Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapentta-3-en-1-yl)phenyl]propenoate To a 250 ml round bottom flask equipped with magnetic stirrer was charged 3.0 g (0.0148 moles) of 2-hydroxyimino-1-(trans-2-phenylcyclopropyl)-1-propanone in 100 mls of anhydrous dimethylformamide, and 4.1 g (0.0295 moles) of powdered potassium carbonate. The reaction mixture was stirred at ambient temperature for a total of 0.5 hours, followed by the addition of methyl (E)-α-[2-(bromomethyl)phenyl]-β-methoxyacrylate (4.2 g, 0.0148 moles) in one portion. The reaction was stoppered and stirred overnight at ambient temperature The reaction mixture was then was poured into 100 mls of water and extracted with 3 x 100 mls of ether. The ether extract was washed with 2 x 100 mls of water, 100 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 6.0 g of a thick amber liquid which was chromatographed on silica gel with 20 % ethyl acetate, 80% hexane. The pure fractions were combined and concentrated on a rotary evaporator to afford 5.5 g of a thick pale yellow oil in 91.3% isolated yield which was consistent with the desired product as a single oximino isomer of methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]propenoate_upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 1.4 (m, 1H), 1.7 (m, 1H), 1.95 (s, 3H), 2.55 (m, 1H), 3.2 (m, 1H), 3.65 (s, 3H), 3.75 (s, 3H), 5.2 (s, 2H), 7.1-7.4 (m, 9H), 7.5 (s, 1H) Example 2 Preparation of methoxylimine isomer A Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]-propenoate - Compound 13.18A of Table 13 To a 1000 ml round bottom flask equipped with magnetic stirrer was charged 56.4 g (0.138 moles) of methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azahepta-3-en-1-yl)phenyl]propenoate in 600 mls of anhydrous methanol, 23.2 g (0.277 moles) of methoxylamine hydrochloride, and 22 g (0.277 moles) of anhydrous pyridine The reaction mixture was stirred at ambient temperature for a total of 24 hours, then refluxed for approximately 2 hours. The reaction mixture was then cooled and poured into 1000 mls of water and extracted with 3 x 200 mls of ether. The ether extract was washed with 200 mls of 0.1 N aqueous hydrochloric acid solution, 2 x 100 mls of water and 200 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 62 g of a thick amber liquid which was chromatographed on silica gel with 20 % ethyl acetate, 80% hexane. The pure fractions were combined and concentrated on a rotary evaporator to afford 48 g of a thick pale yellow oil in a 79.8% isolated yield which was consistent with the desired product, methoxylimine isomer A, methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]propenoate upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.45 (m, 1H), 2.7 (m, 1H), 3.66 (s, 3H), 3.75 (s, 3H), 3.9 (s, 3H), 5.1 (s, 2H), 7.1-7.4 (m, 9H), 7.56 (s, 1H). Example 3 Preparation of (E)-Methyl 2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]-2-methoxyiminoacetate Compound 2.11 of Table 2 To a 250 ml round bottom flask equipped with magnetic stirrer was charged 2.0 g (0.00985 moles) of 2-hydroxyimino-1-(trans-2-phenylcyclopropyl)-1-propanone in 100 mls of anhydrous dimethylformamide, and 2.8 g (0.0197 moles) of powdered potassium carbonate. The reaction mixture was stirred at ambient temperature for a total of 0.5 hours, followed by the addition of methyl 2-(bromomethyl)phenylglyoxylate O-methyloxime (2.8 g, 0.00985 moles) in one portion. The reaction was stoppered and stirred overnight at ambient temperature The reaction mixture was then was poured into 100 mls of water and extracted with 3 x 100 mls of ether. The ether extract was washed with 2 X 100 mls of water, 100 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 4.1 g of a thick amber liquid in a 100% isolated yield which was consistent with the desired product as a single oximino isomer of (E)-methyl 2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]-2-methoxy-iminoacetate upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 1.4 (m, 1H), 1.7 (m, 1H), 1.95 (s, 3H), 2.55 (m, 1H), 3.1 (m, 1H), 3.8 (s, 3H), 4.0 (s, 3H), 5.15 (s, 2H), 7.1-7.4 (m, 9H) Example 4 Preparation of methoxylimine isomer A (E)-methyl-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl] 2-methoxyiminoacetate - Compound 14.18A of Table 14 To a 1000 ml round bottom flask equipped with magnetic stirrer was charged 87 g (0.213 moles) of the (E)-methyl 2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]-2-methoxyiminoacetate 600 mls of anhydrous methanol, 35.6 g (0.426 moles) of methoxylamine hydrochloride, and 33.7 g (0.426 moles) of anhydrous pyridine The reaction mixture was stirred at ambient temperature for a total of 24 hours, then refluxed for approximately 2 hours. The reaction mixture was then cooled and poured into 1000 mls of water and extracted with 3 x 200 mls of ether. The ether extract was washed with 200 mls of 0.1 N aqueous hydrochloric acid solution, 2 x 100 mls of water and 200 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford a thick amber liquid which crystallized upon standing Slurried the solid in hexane and collected by vacuum filtration. Isolated 66.1 g of a tan solid in 71% isolated yield which was consistent with the desired product, methoxylimine isomer A, (E)-methyl-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl] 2-methoxyiminoacetate upon analysis by 300Mz 1 H NMR NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 1.1 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.45 (m, 1H), 2.7 (m, 1H), 3.8 (s, 3H), 3.9 (s, 3H), 4.0 (s, 3H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) Example 5 Preparation of methoxylimine isomer A, N-Methyl (E)2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl] 2-methoxyiminoacetamide - Compound 1518A of Table 15 To a 1000 ml round bottom flask equipped with magnetic stirrer was charged 66.1 g (0.151 moles) of methoxylimine isomer A of (E)-methyl-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl] 2-methoxyiminoacetate,500 mls of anhydrous methanol, and 23.5 g (0.3 moles) of 40% aqueous methylamine solution. The reaction mixture was stirred at ambient temperature for a total of 24 hours, then poured into 1000 mls of water and extracted with 3 x 200 mls of ether. The ether extract was washed with 200 mls of 0.1 N aqueous hydrochloric acid solution, 2 x 100 mls of water and 200 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford a thick amber liquid which crystallized upon standing. Isolated 62 g of a tan solid in a 94% isolated yield which was consistent with the desired product, methoxylimine isomer A: N-methyl (E)2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl - 2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl] 2-methoxyiminoacetatamide upon analysis by 300Mz 1 H NMR.. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 1.2 (m, 1H), 1.8 (m, 1H), 2.0 (s, 3H), 2.45 (m, 1H), 2.8 (m, 1H), 2.9 (d, 3H), 3.9 (s, 3H), 3.92 (s, 3H), 5.0 (s, 2H), 6.8 (bs, 1H), 7.0 (d, 2H), 7.1-7.4 (m, 7H) Example 6 Preparation of Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]propenoate Compound 1.67 of Table 1 Preparation of trans-5-methyl-1-phenyl-hexen-3-one To a 250 ml round bottom flask equipped with magnetic stirrer was charged 11.6 g (0.116 moles) of 4-methyl-2-pentanone, 100 mls of ethanol, and 10 mls of water. To this solution was then added 0.5 g of barium hydroxide monohydrate, followed by 12.3 g (0.116 moles) of benzaldehyde. The flask was stoppered and stirred overnight at ambient temperature. The reaction mixture was then poured into 200 mls of water and extracted with 3 x 100 mls of ethyl ether. The ether extract was washed with 100 mls of saturated aqueous sodium bisulfite solution, followed by 100 mls of water, and 100 mls of saturated aqueous sodium chloride solution. The ether extract was then dried over anhydrous magnesium sulfate, filtered and concentrated on a rotary evaporator to afford 19.8 g of a pale yellow liquid in a 91% isolated yield which was consistent with the desired product trans-5-methyl-1-phenyl-1-hexen-3-one upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 0.99 (d, 6H), 2.2 (m, 1H), 2.5 (d, 2H), 7.7 (d, 1H), 7.4 (m, 3H), 7.6 (m, 3H) Preparation of trans-2-phenylcyclopropyl iso-butylketone To a 500 ml round bottom flask equipped with magnetic stirrer, nitrogen inlet, and pressure equalized addition funnel was charged 23 g (0.104 moles) of trimethylsulfoxonium iodide, 4.2 g (0.104 moles) of powdered sodium hydroxide, and 150 mls of dimethylsulfoxide. The solution was stirred at ambient temperature for 30 minutes, followed by the rapid addition of trans-5-methyl-1-phenyl-1-hexen-3-one, (19.6 g, 0.104 moles) in 100 mls of dimethylsulfoxide. The reaction was then stirred for 60 minutes at ambient temperature, then poured into 200 mls of water and extracted with 3 x 100 mls of ethyl ether. The ether extract was washed with 2 x 100 mls of water, and 100 mls of saturated aqueous sodium chloride solution. The ether extract was dried over anhydrous magnesium sulfate, filtered and concentrated on a rotary evaporator to afford 18.4 g of a thick yellow liquid in a 87.6% isolated which was consistent with the desired product, trans-2-phenylcyclopropyl iso-butylketone upon analysis by 300Mz 1 H NMR. yield. NMR (300 MHz, 1 H, CDCl 3 , TMS=0 ppm) 0.95 (d, 6H), 1.4 (m, 1H), 1.7 (m, 1H), 2.2 (m, 2H), 2.4 (d, 2H), 2.45 (m, 1H), 7.1 (d, 2H), 7.2-7.4 (m, 3H). Preparation of 2-bydroxyimino-3-methyl-1-(trans-2-phenylcyclopropyl)-1-butanone To a dry 500 ml round bottom flask equipped with magnetic stirrer, nitrogen inlet, reflux condenser, and side arm addition funnel was charged 11.2 g . (0.1 moles) of potassium t-butoxide and 150 ml of t-butanol. When all of the solid was dissolved, trans-2-phenylcyclopropyl iso-butylketone (18.4 g, 0.0911 moles)was added in on portion, followed by the drop wise addition of 32 g (0.282 moles) of 90% t-butyl nitrite. The reaction was stirred for 3 hours at ambient temperature then carefully quenched with 100 mls 0.1 N aqueous hydrochloric acid solution. The mixture was extracted with 3 x 100 mls of ethyl ether. The ether extract was then washed with 2 x 100 mls of water and 100 mls of saturated aqueous sodium chloride solution, then dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 9.1 g of a thick brown liquid which crystallized upon standing. The resulting solid was slurried in hexane and collected by vacuum filtration to afford 8.4 g of a tan solid in a 40% isolated yield which was consistent with the desired product as a single hydroxyimino isomer, 2-hydroxyimino-3-methyl-1-(trans-2-phenylcyclopropyl)-1-butanone upon analysis by 300Mz 1 H NMR. 40% isolated yield. NMR (300 MHz, 1 H NMR, CDCl 3 , TMS=0 ppm) 1.2 (d, 6H), 1.3 (m, 1H), 1.7 (m, 1H), 2.5 (m, 1H), 3.1 (m, 1H), 3.4 (q, 1H), 7.1 (d, 2H), 7.2-7.4 (m, 3H), 8.1 (bs, 1H). Preparation of Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azahenta-3-en-1-yl)phenyl]propenoate To a 50 ml round bottom flask equipped with magnetic stirrer was charged 1.0 g (0.00432 moles) of 2-hydroxyimino-3-methyl-1-(trans-2-phenylcyclopropyl)-1-butanone, 10 mls of anhydrous dimethylformamide, and 1.2 g (0.00865 moles) of powdered potassium carbonate. The reaction mixture was stirred at ambient temperature for a total of 0.5 hours, followed by the addition of methyl (E)-α-[2-(bromomethyl)phenyl]-β-methoxyacrylate (1.3 g, 0.00432 moles) in one portion. The reaction was stoppered and stirred overnight at ambient temperature The reaction mixture was then was poured into 100 mls of water and extracted with 3 x 100 mls of ether. The ether extract was washed with 2 x 100 mls of water, 100 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 1.8 g of a thick amber liquid which was chromatographed on silica gel with 20 % ethyl acetate, 80% hexane. The pure fractions were combined and concentrated on a rotary evaporator to afford 1.2 g of a thick pale yellow oil in a 64% isolated yield which was consistent with the desired product as a single oximino isomer, methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]propenoate upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H NMR, CDCl 3 , TMS=0 ppm) 1.2 (d, 6H), 1.3 (m, 1H), 1.6 (m, 1H), 2.55 (m, 1H), 3.1 (m, 1H), 3.4 (q, 1H), 3.7 (s, 3H), 3.78 (s, 3H), 5.15 (s, 2H), 7.1-7.5 (m, 9H), 7.6 (s, 1H) Example 7 Preparation of methoxylimine isomers A and B: Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylpyclopropyl)-4-isopropyl-2.7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]propenoate Compound 13.67A and 13.67B of Table 13 To a 100 ml round bottom flask equipped with magnetic stirrer was charged 1.0 g (0.00229 moles) of single oximino isomer of methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapenta-3-en-1-yl)phenyl]propenoate_50 mls of anhydrous methanol, 1.0 g (0.0115 moles) of methoxylamine hydrochloride, and 1.0 g (0.0115 moles) of anhydrous pyridine The reaction mixture was stirred at ambient temperature for a total of 24 hours, then refluxed for approximately 10 minutes. The reaction mixture was then cooled and poured into 100 mls of water and extracted with 3 x 100 mls of ether. The ether extract was washed with 100 mls of 0.1 N aqueous hydrochloric acid solution, 2 x 100 mls of water and 100 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 1.1 g of a thick amber liquid which was chromatographed on silica gel with 20 % ethyl acetate, 80% hexane. The pure fractions were combined and concentrated on a rotary evaporator to afford 350 mg of a thick pale yellow oil consistent with the desired product as methoxylimine isomer A, methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-isopropyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]propenoate_upon analysis by 300Mz 1H NMR, and 530 mg of a thick pale yellow oil consistent with the desired product as methoxylimine isomer B, methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-isopropyl-2,7-dioxa-3,6-cliazaocta-3-en-1-yl)phenyl]propenoate_upon analysis by 300Mz 1 H NMR in a combined 85% isolated yield. Methoxylimine Isomer A: NMR (300 MHz, 1 H NMR, CDCl 3 , TMS=0 ppm) 1.2 (m, 7H), 1.3 (m, 1H), 2.2 (m, 1H), 2.4 (m, 1H), 3.4 (q, 1H), 3.7 (s, 3H), 3.78 (s, 3H), 3.9 (s, 3H), 5.05 (s, 2H), 7.1-7.5 (m, 9H), 7.6 (s, 1H) Methoxylimine Isomer B: NMR (300 MHz, 1 H NMR, CDCl 3 , TMS=0 ppm) 1.2 (m, 7H), 1.3 (m, 1H), 1.8 (m, 1H), 2.2 (m, 1H), 3.1 (q, 1H), 3.6 (s, 3H), 3.70 (s, 3H), 3.75 (s, 3H), 5.0 (s, 2H), 7.1-7.4 (m, 9H), 7.5 (s, 1H). Example 8 Preparation of hydroxylimine isomer A: Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazahepta-3,5-dien-1-yl)phenyl]-propenoate Compound 13.11A of Table 13 To a 100 ml round bottom flask equipped with magnetic stirrer was charged 1.0 g (0.00245 moles) a single oximino isomer of methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapentta-3-en-1-yl)phenyl]propenoate, 50 mls of anhydrous methanol, 1.7 g (0.0245 moles) of hydroxylamine hydrochloride, and 1.9 g (0.0245 moles) of anhydrous pyridine The reaction mixture was stirred at ambient temperature for a total of 24 hours, then refluxed for approximately 2 hours. The reaction mixture was then cooled and poured into 100 mls of water and extracted with 3 x 100 mls of ether. The ether extract was washed with 100 mls of 0.1 N aqueous hydrochloric acid solution, 2 x 100 mls of water and 100 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 1.1 g ofa thick amber liquid which was chromatographed on silica gel with 15 % ethyl acetate, 85% hexane. The pure fractions were combined and concentrated on a rotary evaporator to afford 650 mg of a thick clear colorless oil in a 63% isolated yield which was consistent with the desired product as a single hydroxyimino isomer A, methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazahepta-3,5-dien-1-yl)phenyl]propenoate upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H NMR, CDCl 3 , TMS=0 ppm) 1.8 (m, 1H), 2.0 (s, 3H), 2.5 (m, 1H), 2.7 (m, 1H), 3.65 (s, 3H), 3.75 (s, 3H), 5.05 (s, 2H), 7.1 (d, 2H), 7.2-7.5 (m, 7H), 7.56 (s, 1H), 8.3 (bs, 1H) Example 9 Preparation of methoxylimine isomer A of Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazadeca-3,5-dien-1-yl)phenyl]-2 propenoate Compound 13.40A of Table 13 To a 50 ml round bottom flask equipped with magnetic stirrer was charged 0.2 g , (0.000474 moles) of hydroxyimino isomer A, methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazahepta-3,5-dien-1-yl)phenyl]propenoate 10 mls of anhydrous dimethylformamide, and 0.13 g (0.00095 moles) of powdered potassium carbonate. The reaction mixture was stirred at ambient temperature for a total of 0.5 hours, followed by the addition of the 1-bromopropane (0.065 g, 0.0005 moles) in one portion. The reaction was stoppered and stirred overnight at ambient temperature The reaction mixture was then was poured into 100 mls of water and extracted with 3 x 100 mls of ether. The ether extract was washed with 2 x 100 mls of water, 100 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 0.2 g of a thick amber liquid which was chromatographed on silica gel with 20 % ethyl acetate, 80% hexane. The pure fractions were combined and concentrated on a rotary evaporator to afford 120 mg of a thick clear colorless oil in a 55% isolated yield consistent with the desired product.,: methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazadeca-3,5-dien-1-yl)phenyl]propenoate, n-propoxyimine isomer A upon analysis by 300Mz 1 H NMR. NMR (300 MHz, 1 H NMR, CDCl 3 , TMS=0 ppm) 0.85 (t, 3H), 1.1 (m, 1H), 1.6 (q, 2H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H), 2.6 (m, 1H), 3.6 (s, 3H), 3.7 (s, 3H), 4.0 (t, 2H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H), 7.6 (s, 1H) Example 10 Preparation of Methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-8,8-dimethyl-2,7-dioxa-3,6-diazanona-3.5-dien-1-yl)phenyl]propenoate Compound 13.43 of Table 13 To a 100 ml round bottom flask equipped with magnetic stirrer was charged 0.5 g (0.00122 moles) of a single oximino isomer of methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2-oxa-5-oxo-3-azapentta-3-en-1-yl)phenyl]propenoate, 50 mls of anhydrous methanol, 1.5 g (0.0122 moles) of O-t-butyl hydroxylamine HCl, and 0.98 g (0.0122 moles) of anhydrous pyridine The reaction mixture was stirred at ambient temperature for a total of 24 hours, then refluxed for approximately 2 hours. The reaction mixture was then cooled and poured into 100 mls of water and extracted with 3 x 100 mls of ether. The ether extract was washed with 100 mls of 0.1 N aqueous hydrochloric acid solution, 2 x 100 mls of water and 100 mls of saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to afford 0.6 g of a thick yellow liquid in a 100% isolated yield which was consistent with the desired product a methyl (E)-3-methoxy-2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-8,8-dimethyl-2,7-dioxa-3,6-diazanona-3,5-dien-1-yl)phenyl]propenoate as mixture of t-butoxyimine isomers: upon analysis by 300Mz 1 H NMR,. NMR (300 MHz, 1 H NMR, TMS=0 ppm) 1.2 (m, 10H), 1.8 (m, 1H), 2.0 (s, 3H), 2.4 (m, 1H), 2.6 (m, 1H), 3.6 (s, 3H), 3.7 (s, 3H), 4.0 (t, 2H), 5.0 (s, 2H), 7.0 (d, 2H), 7.1-7.4 (m, 7H), 7.6 (s, 1H). Proton NMR data (300MHz) are provided in Table 61 for typical examples of Tables 1 to 60 and are illustrative of the present invention* Compound # NMR DATA 1.11 1.4(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.5(m, 1H), 3.15(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 5.2(s, 2H), 7.1-7.4(m, 9H), 7.55(s, 1H) 1.22 1.5(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.6(m, 1H), 3.1(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 3.8(s, 3H), 5.2(s, 2H), 6.8(m, 3H), 7.1-7.4(m, 5H), 7.55(s, 1H) 1.24 1.4(m, 1H), 1.75(m, 1H), 2.0(s, 3H), 2.3(s, 3H), 2.5(m, 1H), 3.1(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 5.2(s, 2H), 7.1-7.4(m, 8H), 7.55(s, 1H) 1.25 1.5(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.35(s, 3H), 2.5(m, 1H), 3.1(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 5.2(s, 2H), 7.0-7.5(m, 8H), 7.55(s, 1H) 1.56 0.85(t, 3H), 1.4(m, 3H), 1.7(m, 1H), 2.5(m, 3H), 3.1(m, 1H), 3.7(s, 3H), 3.75(s, 3H), 5.2(s, 2H), 7.1-7.4(m, 9H), 7.6(s, 1H) 1.67 1.2(d, 6H), 1.3(m, 1H), 1.7(m, 1H), 2.5(m, 1H), 3.1(m, 1H), 3.4(m, 1H), 3.7(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 7.0-7.5(m, 9H), 7.6(s, 1H) 1.78 0.9(t, 3H), 1.4(m, 5H), 1.8(m, 1H), 2.5(m, 3H), 3.2(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 5.2(s, 2H), 7.1-7.4(m, 9H), 7.55(s, 1H) 2.1 1.4(m, 1H), 1.8(m, 1H), 2.6(m, 1H), 3.05(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.2(s, 2H), 7.1-7.45(m, 9H), 7.5(s, 1H) 2.11 1.4(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.5(m, 1H), 3.1(m, 1H), 3.8(s, 3H), 3.95(s, 3H), 5.15(s, 2H), 7.1-7.5(m, 9H) 2.14 1.4(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.5(m, 1H), 3.1(m, 1H), 3.9(s, 3H), 4.05(s, 3H), 5.15(s, 2H), 7.0(d, 2H), 7.1-7.5(m, 6H) 2.22 1.45(m, 1H), 1.7(m, 1H), 1.9(s, 3H), 2.6(m, 1H), 3.1(m, 1H), 3.79(s, 3H), 3.8(s, 3H), 4.0(s, 3H), 5.2(s, 2H), 6.8(m, 3H), 7.1-7.4(m, 5H) 2.24 1.4(m, 1H), 1.75(m, 1H), 2.0(s, 3H), 2.25(s, 3H), 2.5(m, 1H), 3.05(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.2(s, 2H), 7.1-7.4(m, 8H) 2.25 1.5(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.3(s, 3H), 2.6(m, 1H), 3.1(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.2(s, 2H), 7.1-7.4(m, 8H) 2.45 0.95(t, 3H), 1.3(m, 1H), 1.8(m, 1H), 2.5(m, 3H), 3.2(m, 1H), 3.7(s, 3H), 3.75(s, 3H), 5.2(s, 2H), 7.0-7.5(m, 9H), 7.55(s, 1H) 2.45 1.0(t, 3H), 1.3(m, 1H), 1.8(m, 1H), 2.5(m, 3H), 3.1(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.15(s, 2H), 7.0-7.5(m, 9H) 2.56 0.9(t, 3H), 1.4(m, 3H), 1.7(m, 1H), 2.5(m, 3H), 3.1(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.1(s, 2H), 7.1-7.4(m, 9H) 2.67 1.15(d, 6H), 1.25(m, 1H), 1.7(m, 1H), 2.5(m, 1H), 3.1(m, 1H), 3.4(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.1(s, 2H), 7.0-7.5(m, 9H) 2.78 0.85(t, 3H), 1.4(m, 5H), 1.75(m, 1H), 2.5(m, 3H), 3.2(m, 1H), 3.8(s, 3H), 4.0(s, 3H), 5.15(s, 2H), 7.1-7.5(m, 9H) 3.22 1.4(m, 1H), 1.7(m, 1H), 1.85(s, 3H), 2.5(m, 1H), 2.8(d, 3H), 3.1(m, 1H), 3.75(s, 3H), 3.85(s, 3H), 5.1(s, 2H), 6.8(m, 3H), 7.1-7.4(m, 6H) 10.5 1.0(d, 6H), 1.3(m, 1H), 1.6(m, 2H), 3.55(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 5.0(s, 2H), 7.1-7.4(m, 9H), 7.55(s, 1H) 13.7 1.15-1.3(m, 2H), 2.15-2.25(m, 1H), 2.26-2.4(m, 1H), 3.65(s, 3H), 3.85(s, 3H), 5.07(s, 2H), 7.0-7.6(m, 10H), 7.56(s, 1H), 8.33(s, 1H) 13.11A 1.8(m, 1H), 2.0(s, 3H), 2.5(m, 1H), 2.7(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 5.05(s, 2H), 7.1(d, 2H), 7.2-7.5(m, 7H), 7.56(s, 1H), 8.3(bs, 1H) 13.18A 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.45(m, 1H), 2.7(m, 1H), 3.66(s, 3H), 3.75(s, 3H), 3.9(s, 3H), 5.1(s, 2H), 7.1-7.4(m, 9H), 7.56(s, 1H) 13.18B 1.2(m, 1H), 1.4(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.2(m, 1H), 3.6(s, 3H), 3.7(s, 3H), 3.85(s, 3H), 5.1(s, 2H), 6.9(d,2H), 7.1-7.4(m, 7H), 7.56(s, 1H) 13.20A 1.1(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.7(m, 1H), 3.6(s, 3H), 3.7(s, 3H), 3.85(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 6H), 7.6(s, 1H) 13.22A 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.9(m, 1H), 3.7(s, 3H), 3.8(s, 3H), 3.95(s, 3H), 5.0(s, 2H), 6.9-7.0(m, 3H), 7.1-7.4(m, 5H), 7.6(s, 1H) 13.23 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.3(m, 1H), 2.5(m, 1H), 3.65(s, 3H), 3.8(s, 3H), 3.9(s, 3H), 5.0(s, 2H), 6.8.0-7.0(m, 3H), 7.1-7.4(m, 5H), 7.6(s, 1H) 13.25A 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.25(s, 3H), 2.45(m, 1H), 2.8(m, 1H), 3.6(s, 3H), 3.75(s, 3H), 3.9(s, 3H), 5.1(s, 2H), 7.1-7.4(m, 8H), 7.6(s, 1H) 13.26 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.3(s, 3H), 2.5(m, 1H), 2.8(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 3.9(s, 3H), 5.1(s, 2H), 6.9-7.0(m, 3H), 7.1-7.4(m, 5H), 7.6(s, 1H) 13.39 1.1(m, 1H), 1.3(t, 3H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.7(m, 1H), 3.6(s, 3H), 3.7(s, 3H), 4.1(m, 2H), 5.1(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 13.40A 0.85(t, 3H), 1.1(m, 1H), 1.6(q, 2H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.6(m, 1H), 3.6(s, 3H), 3.7(s, 3H), 4.0(t, 2H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 13.42A 0.9(t, 3H), 1.1(m, 1H), 1.3(m, 2H), 1.6(m, 2H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.7(m, 1H), 3.65(s, 3H), 3.75(s, 3H), 4.1(t, 2H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 13.43 1.2(m, 10H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.6(m, 1H), 3.6(s, 3H), 3.7(s, 3H), 4.0(t, 2H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 13.44A 1.1(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.4(m, 1H), 2.5(s, 1H), 2.7(m, 1H), 3.6(s, 3H), 3.7(s, 3H), 4.6(d, 2H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 13.45A 1.0(t, 3H), 1.1(m, 1H), 1.3(m, 1H), 1.8(m, 1H), 2.2(m, 1H), 2.5(q, 2H), 3.6(s, 3H), 3.7(s, 3H), 3.75(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 13.45B 1.0(t, 3H), 1.1(m, 1H), 1.3(m, 1H), 1.7(m, 1H), 2.5(m, 1H), 2.6(q, 2H), 3.65(s, 3H), 3.75(s, 3H), 3.9(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 13.56A 0.95(t, 3H), 1.2(m, 1H), 1.5(m, 2H), 1.7(m, 1H), 2.45(m, 1H), 2.7(m, 3H), 3.65(s, 3H), 3.75(s, 3H), 3.9(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 13.67A 1.2(m, 7H), 1.3(m, 1H), 2.2(m, 1H), 2.4(m, 1H), 3.4(q, 1H), 3.7(s, 3H), 3.78(s, 3H), 3.9(s, 3H), 5.05(s, 2H), 7.1-7.5(m, 9H), 7.6(s, 1H) 13.67B 1.2(m, 7H), 1.3(m, 1H), 1.8(m, 1H), 2.2(m, 1H), 3.1(q, 1H), 3.6(s, 3H), 3.70(s, 3H), 3.75(s, 3H), 5.0(s, 2H), 7.1-7.4(m, 9H), 7.5(s, 1H) 13.78A 0.9(t, 3H), 1.2(m, 1H), 1.4(m, 2H), 1.5(m, 2H), 1.8(m, 1H), 2.4(m, 1H), 2.6(m, 3H), 3.65(s, 3H), 3.75(s, 3H), 3.9(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H), 7.6(s, 1H) 14.7 1.10-1.25(m, 2H), 2.10-2.20(m, 1H), 2.25-2.35(m, 1H), 2.87-2.88(d, 3H), 3.85(s, 3H), , 3.92(s, 3H), 5.05(s,2H), 6.6-6.8(br s, 1H), 7.0-7.5(m, 9H,) 8.29(s, 1H). 14.18A 1.1(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.45(m, 1H), 2.7(m, 1H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H) 14.20 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.6(m, 1H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 6.9(d, 2H), 7.1-7.4(m, 6H) 14.21 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.7(m, 1H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 6H) 14.22 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.7(m, 1H), 3.75(s, 3H), 3.85(s, 3H), 3.95(s, 3H), 5.0(s, 2H), 6.9-7.2(m, 3H), 7.3-7.5(m, 5H) 14.23 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.3(m, 1H), 2.5(m, 1H), 3.7(s, 3H), 3.85(s, 3H), 3.95(s, 3H), 4.95(s, 2H), 6.8.0-7.0(m, 3H), 7.1-7.4(m, 5H) 14.25A 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.25(s, 3H), 2.5(m, 1H), 2.8(m, 1H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.1(s, 2H), 7.1-7.2(m, 5H), 7.4(m, 3H) 14.26 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.3(s, 3H), 2.4(m, 1H), 2.6(m, 1H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 7.0-7.2(m, 3H), 7.3-7.5(m, 5H) 14.31 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.4(m, 1H), 2.55(m, 1H), 3.7(s, 3H), 3.75(s, 3H), 3.9(s, 3H), 3.95(s, 3H), 5.0(s, 2H), 6.7(d, 2H), 7.1-7.4(m, 6H) 14.45 1.1(t, 3H), 1.2(m, 1H), 1.8(m, 1H), 2.4(m, 2H), 2.5(q, 2H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H) 14.56A 0.95(t, 3H), 1.2(m, 1H), 1.5(m, 2H), 1.7(m, 1H), 2.45(m, 1H), 2.7(m, 3H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H) 14.67A 1.2(m, 7H), 1.4(m, 1H), 2.2(m, 1H), 2.4(m, 1H), 3.2(q, 1H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H) 14.67B 1.2(m, 7H), 1.3(m, 1H), 1.8(m, 1H), 2.2(m, 1H), 3.1(q, 1H), 3.8(s, 6H), 3.95(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H) 14.78A 0.9(t, 3H), 1.2(m, 1H), 1.4(m, 2H), 1.5(m, 2H), 1.7(m, 1H), 2.4(m, 1H), 2.6(m, 3H), 3.8(s, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 7.0(d, 2H), 7.1-7.4(m, 7H) 15.7 1.10-1.25(m, 2H), 2.10-2.20(m, 1H), 2.25-2.25(m, 1H), 3.82(s, 3H), 3.85(s, 3H), 3.99(s, 3H), 5.04(s,2H), 7.0-7.5(m, 9H), 7.56(s, 1H), 8.28(s, 1H) 15.21 1.2(m, 1H), 1.7(m, 1H), 1.9(s, 3H), 2.2(m, 1H), 2.6(m, 1H), 2.9(d, 3H), 3.8(s, 3H), 3.9(s, 3H), 5.0(s, 2H), 6.8(bs, 1H), 7.0(d, 2H), 7.1-7.4(m, 6H) 15.18A 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.45(m, 1H), 2.8(m, 1H), 2.9(d, 3H), 3.9(s, 3H), 3.92(s, 3H), 5.0(s, 2H), 6.8(bs, 1H), 7.0(d, 2H), 7.1-7.4(m, 7H) 15.18B 1.2(m, 1H), 1.4(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.2(m, 1H), 2.85(d, 3H), 3.9(s, 3H), 3.95(s, 3H), 5.0(s, 2H), 6.7(bs, 1H), 7.0(d, 2H), 7.1-7.4(m, 7H) 15.20 1.1(m, 1H), 1.8(m, 1H), 1.9(s, 3H), 2.3(m, 1H), 2.6(m, 1H), 2.8(d, 3H), 3.85(d, 6H), 5.0(s, 2H), 6.7(bs, 1H), 6.9-7.4(m, 8H) 15.22A 1.1(m, 1H), 1.8(m, 1H), 1.9(s, 3H), 2.3(m, 1H), 2.8(d, 3H), 2.9(m, 1H), 3.85(d, 6H), 5.0(s, 2H), 6.7(bs, 1H), 6.9-7.4(m, 8H) 15.24 1.1(m, 1H), 1.7(m, 1H), 1.9(s, 3H), 2.2(m, 1H), 2.6(m, 1H), 2.8(d, 3H), 3.85(d, 6H), 4.98(s, 2H), 6.8(bs, 1H), 6.9-7.4(m, 8H) 15.25A 1.2(m, 1H), 1.8(m, 1H), 2.0(s, 3H), 2.2(s, 3H), 2.6(m, 1H), 2.8(m, 1H), 2.85(d, 3H), 3.85(s, 6H), 4.95(s, 2H), 6.8(bs, 1H), 7.0-7.4(m, 8H) 15.26A 1.2(m, 1H), 1.7(m, 1H), 1.9(s, 3H), 2.2(s, 3H), 2.4(m, 1H), 2.7(m, 1H), 2.8(d, 3H), 3.85(d, 6H), 4.98(s, 2H), 6.8(bs, 1H), 6.9-7.4(m, 8H) 15.26B 1.1(m, 1H), 1.4(m, 1H), 1.8(m, 1H), 1.9(s, 3H), 2.1(m, 1H), 2.2(s, 3H), 2.8(d, 3H), 3.75(s, 3H), 3.85(s, 3H), 4.95(s, 2H), 6.7(bs, 1H), 6.8(d, 2H), 6.9-7.4(m, 6H) 15.31 1.2(m, 1H), 1.8(m, 1H), 1.95(s, 3H), 2.4(m, 1H), 2.55(m, 1H), 2.9(d, 3H), 3.75(s, 3H), 3.8(s, 3H), 3.83(s, 3H), 5.0(s, 2H), 6.6(d, 2H), 7.1-7.4(m, 6H) 15.45 1.0(t, 3H), 1.2(m, 1H), 1.7(m, 1H), 2.3(m, 2H), 2.4(m, 1H), 2.5(q, 2H), 2.8(d, 2H), 3.8(s, 3H), 3.85(s, 3H), 4.95(s, 2H), 6.7(bs, 1H), 6.9(d, 2H), 7.1-7.4(m, 7H) 15.56A 0.9(t, 3H), 1.2(m, 1H), 1.5(m, 2H), 1.8(m, 1H), 2.4(m, 1H), 2.6(m, 3H), 2.9(d, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 6.8(bs, 1H), 7.0(d, 2H), 7.1-7.4(m, 7H) 15.67A 1.1(m, 7H), 1.2(m, 1H), 2.2(m, 1H), 2.4(m, 1H), 2.9(d, 3H), 3.1(q, 1H), 3.8(s, 3H), 3.9(s, 3H), 4.95(s, 2H), 6.8(bs, 1H), 7.0(d, 2H), 7.1-7.4(m, 7H) 15.67B 1.1(m, 6H), 1.2(m, 1H), 1.4(m, 1H), 1.8(m, 1H), 2.2(m, 1H), 2.8(d, 3H), 3.0(q, 1H), 3.75(s, 3H), 3.9(s, 3H), 4.95(s, 2H), 6.7(bs, 1H), 7.0(d, 2H), 7.1-7.4(m, 7H) 15.78A 0.9(t, 3H), 1.2(m, 1H), 1.4(m, 2H), 1.5(m, 2H), 1.7(m, 1H), 2.4(m, 1H), 2.6(m, 3H), 2.9(d, 3H), 3.9(s, 3H), 4.0(s, 3H), 5.0(s, 2H), 6.8(bs, 1H), 7.0(d, 2H), 7.1-7.4(m, 7H) *NMR data for compounds designated by A or B are data for one single stereoisomer for R 9 ON=C Compounds without designation are a mixture of stereoisomers and the data provided is for the major isomer. Example 11 Numerous compounds of this invention were tested for fungicidal activity in vivo against the diseases described below. The compounds were dissolved a 1:1 mixture of acetone and methanol or N, N-dimethylformamide and diluted with a 2:1:1 mixture of water, acetone, and methanol (by volume) or water, respectively, to achieve the appropriate concentration. The solution was sprayed onto the plants, and allowed to dry (two hours). Then the plants were inoculated with fungal spores. Each test utilized control plants which were sprayed with the appropriate solvent mixture and inoculated. For these protective tests, the plants were inoculated one day after treating the plants with the fungicide compound. The remainder of the technique of each of the tests is given below along with the results for various compounds described herein by the Compound # against the various fungi at a dose of 150 grams per hectare. The results are percent disease control are compared to the untreated check wherein one hundred was rated as complete disease control and zero as no disease control. Wheat Leaf Rust (WLR) Puccinia recondita (f. sp. tritici ) was cultured on 7-day old wheat (cultivar Fielder) over a 12-day period in the greenhouse. Spores were collected from the leaves by settling on aluminum foil. The spores were cleaned by sieving through a 250-micron opening screen and stored dry. The dried spores were used within one month. A spore suspension was prepared from dry uredia by adding 20 mg (9.5 million spores) per ml of Soltrol oil. The suspension was dispensed into gelatin capsules (0.7 ml capacity) which attach to the oil atomizers. One capsule is used per flat of twenty 2-inch square pots of 7-day old wheat plants, cultivar Fielder After waiting for at least 15 minutes for the oil to evaporate from the wheat leaves, the plants were placed in a dark mist chamber (18-20°Cand 100% relative humidity) for 24 hours. The plants were then placed in the greenhouse and evaluated after 12 days for disease Wheat Leaf Blotch (SNW) Cultures of Septoria nodorum was maintained on Czapek-Dox V-8 juice agar plates in an incubator at 20°Cwith alternating periods of 12 hours of light and 12 hours of darkness for 2 weeks. A water suspension of the spores was obtained by shaking the portion of the plate with fungal material in deionized water and filtering through cheesecloth. The spore-containing water suspension was diluted to a spore concentration of 3.0 x 10 6 spores per ml. The inoculum was dispersed by a DeVilbiss atomizer over one-week old Fielder wheat plants which had been previously sprayed with the fungicide compound. The inoculated plants were placed in a humidity cabinet at 20°Cwith alternating 12 hours of light and 12 hours of darkness for 7 days. The inoculated seedlings were then moved to a controlled environment room at 20°Cfor 2 days of incubation. Disease control values were recorded as percent control. Wheat Powdery Mildew (WPM) Erysiphe graminis (f. sp. tritici ) was cultured on wheat seedlings, cultivar Fielder, in a controlled temperature room at 18°C. Mildew spores were shaken from the culture plants onto 7-day old wheat seedlings which had been previously sprayed with the fungicide compound. The inoculated seedlings were kept in a controlled temperature room at 18°Cand subirrigated. The percent disease control was rated 7 days after the inoculation. Cucumber Powdery Mildew (CPM) Sphaerotheca fulginea was maintained on cucumber plants, cultivar. Bush Champion, in the greenhouse. Inoculum was prepared by placing five to ten heavily mildewed cucumber leaves in a glass jar with 500 ml of water containing one drop of Tween 80 per 100 ml. After shaking the liquid and leaves , the inoculum was filtered through cheese cloth and misted onto the plants with a squirt bottle mister. The spore count was 100, 000 spores/ml. The plants were then placed in the greenhouse for infection and incubation. The plants were scored seven days after inoculation. Disease control values were recorded as percent control. Tomato Late Blight (TLB) Cultures of Phytophthora infestans were maintained on green pea-amended agar for two to three weeks. The spores were washed from the agar with water and dispersed with a DeVilbiss atomizer over the leaves of 3-week old Pixie tomato plants which had been previously treated with experimental fungicides: The inoculated plants were placed in a humidity cabinet at 20°Cfor 24 hours for infection. The plants were then removed to a controlled environment room at 20°Cand 90% humidity. The plants were scored for disease control after five days. Grape Downy Mildew (GDM) Plasmopara viticola was maintained on leaves of grape plants, cultivar. Delaware, in a controlled temperature chamber at 20°Cin humid air with moderate light intensity for 7 to 8 days. A water suspension of the spores from infested leaves was obtained and the spore concentration was adjusted to about 3 x 10 5 per ml of water. Delaware grape plants were inoculated by spraying the underside of leaves with a DeVilbiss atomizer until small drops were observed on the leaves. The inoculated plants were incubated in a mist chamber for 24 hours at 20°C. The plants were then removed to a controlled environmental room at 20°C Disease control values were recorded as percent control seven days after inoculation. Rice Blast (RB) Cultures of Pyricularia oryzae were maintained on potato dextrose agar for two to three weeks. The spores were washed from the agar with water containing 1 drop of Tween 80 per 100 ml water. After filtering the spore suspension through two layers of cheese cloth, the spore count was adjusted to 5 x 10 5 . The spore suspension was sprayed onto 12-day old rice plants, cultivar M-1, using a DeVilbiss atomizer. The inoculated plants were placed in a humidity cabinet at 20 C for 36 hours to allow for infection. After the infection period, the plants were placed in the greenhouse. After 6 days, the plants were scored for disease control. Cucumber Anthracnose (CA) The fungal pathogen Colletotrichum lagenarium was cultured on potato dextrose agar (PDA) in the dark at 22 C for a period of 8 to 14 days. Spores of C. lagenarium were removed from the PDA plates by flooding the plate surface with distilled water, amended with 0.5% v/w of yeast extract. The upper surface of the fungal colony was scraped with a blunt instrument until most of the spores were released into the aqueous environment. The spore suspension was filtered though cheesecloth, and the spore count was adjusted by adding more water, containing the yeast extract, until 3.0 x 10 6 spores per ml was achieved. The chemically-treated cucumber plants were 15-days old, cultivar Bush Champion. The upper leaf surface of the plants were sprayed with the spore suspension until runoff, using a hand-held pump spray bottle. The plants were placed in a fluorescent-lighted mist chamber (12 hr light, 12 hr dark) for 48 hours. After that infection period, the plants were placed in a growth chamber for 3 days at 25 C and 90% humidity. The treated plants were then evaluated for disease control. Botrytis (BOT) The fungal pathogen Botrytis cinerea was cultured on potato dextrose agar (PDA) under fluorescent lights (12 hr on, 12 hr off) for a period of 2 to 3 weeks. Spores of B. cinerea were removed from the PDA plates by flooding the plate surface with distilled water, amended with 0.5% v/w of yeast extract. The upper surface of the fungal colony was scraped with a rubber instrument until most of the spores were released into the aqueous environment. The spore suspension was filtered though cheesecloth, and the spore count was adjusted by adding more water, containing the yeast extract, until 3.0 x 10 6 spores per ml was achieved. Chemically-treated sweet bell pepper plants were 19-days old, cultivar California Wonder. The entire leaf surface of the plants were sprayed with the spore suspension until runoff, using a DeVilbiss atomizer. The plants were placed in a low light mist chamber (12 hr light, 12 hr dark) at 22 C for 4 or 5 days. The treated plants were then evaluated for disease control. When tested against wheat leaf rust at 150 grams per hectare compounds 1.11, 1.24, 1.25, 2.24, 2.25, 3.22, 13.7, 13.11A, 13.18A, 13.18B, 13.20A, 13.22A, 13.39, 13.40A, 13.42A, 13.44A, 13.45A, 13.45B, 13.56A, 13.67B, 14.18A, 14.20, 15.7, 15.2115.18A, 15.18B, 15.20, 15.22A, 15.24, 15.31, 15.45, 15.56A, 15.67A and 15.78 exhibited 99 % or better control. When tested against septoria nodorum at 150 grams per hectare compounds 1.11, 2.14, 13.18A, 13.18B, 14.21, 14.18A, 15.7, 15.18A and 15.18B exhibited 90% or better control. When tested against wheat powdery mildew at 150 grams per hectare compounds 1.24, 1.25, 2.11, 2.45, 3.22, 13.7, 13.18A, 13.22A, 13.23, 14.7,14.18A 14.21, 14,22, 14.23, 14.45, 14.67A, 15.18B, , 15.24, 15.26A and 15.31,exhibited 90% or better control. When tested against cucumber powdery mildew at a dose of 150 grams per hectare, compounds, 13.18A, 13.20A, 13.22A, 13.23, 13.25A, 13.26, 13.39, 13.40A, 13.42A, 13.43, 13.44A, 13.45A, 13.56A, 13.67A, 14.20, 14.22, 14.25A, 14.26, 14.31, 14.45, 14.67A, 15.18A, 15,18B, 15.20, 15.22A, 15.24, 15.25A, 15.26A, 15.26B, 15.31, 15.45, 15.56A and 15.67A exhibited 100 %.control. When tested against tomato late blight at 150 grams/hectare compounds 1.11, 1.22, 1.24, 1.25, 2.11, 2.45, 3.22, 13.18A, 13.23, 13.45B, 13.67A, 15.21, 15.18A 15.26A, 15.45, 15.67A and 15.67B exhibited 90% or better control. When tested against grape downy mildew at 150 grams/hectare compounds 2.1, 2.11, 2.14, 13.7, 13.18A, 13.18B, 14.7, 14.18A, 14.21, 15.7, 15.18A, 15.18B, 15.25A, and 15.67A exhibited 99% or better control. When tested against rice blast at 150 grams/hectare compounds 1.11, 1.22, 1.24, 1.25, 2.24, 13.18A, 13.18B, 13.23, 13.25A, 13.45A, 14.21, 14.18A 14.23, 14.26, 14.45, 15.18A, 15.18B, 15.21, 15.25A, 15.26A, 15.26B,16.24, 15.31 and 15.45 exhibited 90% or better control. When tested against cucumber anthracnose at 150 grams/hectare compounds 1.24, 13.18A, 13.18B, 13.23, 13.25A, 13.26, 13.45A, 13.67A, 14.21, 14.22, 14.26, 15,7, 15.21, 15.18A, 15.18B,15.25A, 15.26A, 15.26B, 15.45, 15.56A and 15.67Aexhibited 90% or better control. When tested against botrytis at 150 grams/hectare compounds 1.22, 3.22, 13.22A, 13.26, 14.67B, 15.7 and 15.18A exhibited 85% or better control. The compounds of this invention are useful as agricultural fungicides and, as such, can be applied to various loci such as the seed, the soil or the foliage. The compounds of this invention can be applied as fungicidal sprays by methods commonly employed, such as conventional high-volume hydraulic sprays, low-volume sprays, air-blast spray, aerial sprays and dusts. The dilution and rate of application will depend upon the type of equipment employed, the method of application, plants to be treated and diseases to be controlled. Generally, the compounds of this invention will be applied in amount of from 0.005 kilogram to 50 kilograms per hectare and preferably from 0.025 to 25 kilograms per hectare of the active ingredient. As a seed protectant, the amount of toxicant coated on the seed is usually at a dosage rate of from 0.05 to 20, preferably from about 0.05 to 4, and more preferably from 0.1 to 1 grams per hundred kilograms of seed. As a soil fungicide the chemical can be incorporated in the soil or applied to the surface usually at a rate of from 0.02 to 20, preferably from 0.05 to 10, and more preferably from 0.1 to 5 kilograms per hectare. As a foliar fungicide, the toxicant is usually applied to growing plants at a rate of from 0.01 to 10, preferably from 0.02 to 5, and more preferably from 0.25 to 1 kilograms per hectare Inasmuch as the compounds of this invention display fungicidal activity, these compounds can be combined with other known fungicides to provide broad spectrum activity. Suitable fungicides include, but are not limited to, those compounds listed in U.S. Patent Number 5, 252, 594 (see in particular columns 14 and 15). Other known fungicides which an be combined with the compounds of this invention are dimethomorph, famoxadone, zoxamide, cymoxanil, thifluzamide, furalaxyl, ofurace, benalaxyl, oxadixyl, propamocarb, cyprofuram, fenpiclonil, fludioxonil, pyrimethanil, cyprodinil, triticonazole, fluquinconazole, metconazole, spiroxamine, carpropamid, azoxystrobin, kresoxim-methyl, metominostrobin and trifloxystrobin. The compounds of this invention can be advantageously employed in various ways. Since these compounds possess broad spectrum fungicidal activity, they can be employed in the storage of cereal grain. These compounds can also be employed as fungicides in cereals including wheat, barley and rye, in rice, peanuts, beans and grapes, on turf, in fruit, nut and vegetable orchards, and for golf course applications. Examples of diseases against which the compounds of the invention are useful include helminthosporium of corn and barley, wheat and barley powdery mildew, wheat leaf and stem rusts, tomato early blight, tomato late blight, peanut early leaf spot, grape powdery mildew, grape black rot, apple scab, apple powdery mildew, cucumber powdery mildew, brown rot of fruits, botrytis, bean powdery mildew, cucumber anthracnose, wheat septoria nodorum , rice sheath blight and rice blast. Example 12 Numerous compounds of this invention were tested for insecticidal activity in vivo against the insects described below. The following test method was used to evaluate compounds of the present invention for insecticidal activity. The compound to be evaluated was dissolved in an appropriate solvent, usually a mix of acetone, methanol and water, and sprayed over three excised leaf disks using a flat fan nozzle. After spraying, the leaf disks were allowed to dry. A disk was infested with the leaf chewing insects (southern armyworm) and a second leaf disk was already infested with the two-spotted spider mite prior to spraying. The tested insect species were: AW southern armyworm Spodoptera eridamia MTA two-spotted spider mite Teranychus uricate Observations as percent control were made by visual inspection 24-48 hours after spraying. When tested against southern army worm at 150 grams/hectare compounds 13.20A, 13.26, 13.39, 13.40A, 13.42A and 13.45A provided 100% control. When tested against two-spotted spider mite at 150 grams/hectare compounds 1.22, 13.20A, 13.22A, 13.26, 13.39, 13.40A, 13.42A, 13.45A, 13.56A and 15.20 provided 100% control. The compositions and compounds of this invention can be applied directly to the locus to be protected, as for example, the area around or upon economic plants infected with insects or to plants on which infestation is to be prevented. Examples of injurious insects belong to the orders Lepidoptera , Coleoptera , Diptera , Thysanoptera , Hymenoptera , Heteroptera , Homoptera , Orthoptera , and Acarina . The compounds and compositions may be used either as contact or systemic pesticides. The compounds of the invention are applied to the insect's habitat at a rate of 0.0005 to 10 kilograms per hectare, preferably 0.05 to 5 and most preferably from 0.1 to 1 kilogram per hectare. In the practice of the method of the invention, the active compound may be applied to the soil or foliage where it is absorbed by the plant, translocated to other plant parts and ultimately ingested by the pest or insects by means of ingestion of the plant part(s). This means of application is referred to as systemic application. Alternatively, the active compound may be applied to the soil and contacted therein with the insects and other pests to be controlled. This means of application is referred to as soil application. In another alternative, the active compound may be foliarly applied to the plants to be freed from insects and other pests which feed on the foliage. Compositions and formulations according to the present invention may also include known pesticidal compounds. This expands the spectrum of activity of the preparation and may give rise to synergism. Suitable insecticides known in the art include those listed in U.S. Patent 5,075,471, see in particular columns 14 and 15. The compounds of the present invention can be used in the form of compositions or formulations. Examples of the preparation of compositions and formulations can be found in the American Chemical Society publication "Pesticidal Formulation Research, " (1969), Advances in Chemistry Series No. 86, written by Wade Van Valkenburg; and the Marcel Dekker, Inc. publication "Pesticide Formulations", (1973) edited by Wade Van Valkenburg. In these compositions and formulations, the active substance is mixed with conventional inert agronomically acceptable (i.e., plant compatible and/or pesticidally inert) pesticide diluents or extenders such as solid carrier material or liquid carrier material, of the type usable in conventional pesticide compositions or formulations. By "agronomically acceptable carrier is meant any substance which can be used to dissolve, disperse of diffuse the active ingredient in the composition without impairing the active ingredients effectiveness and which by itself has no significant detrimental effect on the soil, equipment, desirable plants, or agronomic environment. If desired, adjuvants such as surfactants, stabilizers, antifoam agents and anti-drift agents may also be combined. Examples of compositions and formulations according to the invention are aqueous solutions and dispersions, oily solutions and oil dispersions, pastes, dusting powders, wettable powders, emulsifiable concentrates, flowables, granules, baits, invert emulsions, aerosol compositions and fumigating candles. Wettable powders, pastes, flowables and emulsifiable concentrates are concentrated preparations which are diluted with water before or during use. In such formulations, the compounds are extended with a liquid or solid carrier and, when desired, suitable surfactants are incorporated. Baits are preparations generally comprising a food or other substance attractive to insects, that includes at least one compound of the instant invention. It is usually desirable, particularly in the case of foliar spray formulations, to include adjuvants, such as wetting agents, spreading agents, dispersing agents, stickers, adhesive and the like in accordance with agricultural practices. Such adjuvants commonly used in the art, and a discussion of adjuvants can be found in many references, such as in the John W. McCutcheon, Inc. publication "Detergents and Emulsifiers, Annual." The active compounds of the present invention may be employed alone or in the form of mixtures with one another and/or with such solid and/or liquid dispersible carrier vehicles and/or with other known compatible active agents, especially plant protection agents, such as other insecticides, arthropodicides, nematicides, fungicides, bactericides, rodenticides, herbicides, fertilizers, growth-regulating agents, synergists. In the compositions of the invention, the active compound is present in an amount substantially between 0.0001 (1:999, 999) -99 (99:1) % by weight. For compositions suitable for storage or transportation, the amount of active ingredient is preferably between 0.5 (1:199) -90 (9:1) % by weight, and more preferably between 1 (1:99) -75 (3:1) % by weight of the mixture. Compositions suitable for direct application or field application generally contain the active compound in an amount substantially between about 0.0001 (1:999, 999) -95 (19:1) %, preferably between 0.0005 (1:199, 999) -90 (9: 1) % by weight, and more preferably between 0.001 (1:99, 999) -75 (3:1) % by weight of the mixture. The composition can also be stated as a ratio of the compound to the carrier. In the present invention the weight ratio of these materials (active compound/carrier) can vary from 99:1 (99%) to 1:4 (20%) and more preferably from 10:1 (91%) to 1:3 (25%). In general, the compounds of this invention can be dissolved in certain solvents such as acetone, methanol, ethanol, dimethylformamide, pyridine or dimethyl sulfoxide and such solutions can be diluted with water. The concentrations of the solution can vary from 1% to 90% with a preferred range being from 5% to 50%. For the preparation of emulsifiable concentrates, the compound can be dissolved in suitable organic solvents, or a mixture of solvents, together with an emulsifying agent to enhance dispersion of the compound in water. The concentration of the active ingredient in emulsifiable concentrates is usually from 10% to 90%, and in flowable emulsion concentrates, can be as high as 75%. Wettable powders suitable for spraying, can be prepared by admixing the compound with a finely divided solid, such as clays, inorganic silicates and carbonates, and silicas and incorporating wetting agents, sticking agents, and/or dispersing agents in such mixtures. The concentration of active ingredients in such formulations is usually in the range of from 20% to 99%, preferably from 40% to 75%. A typical wettable powder is made by blending 50 parts of a compound of Formula I, 45 parts of a synthetic precipitated hydrated silicon dioxide, such as that sold under the trademark Hi-Sil®, and 5 parts of sodium lignosulfonate. In another preparation a kaolin type (Barden) clay is used in place of the Hi-Sil in the above wettable powder, and in another such preparation 25% of the Hi-Sil is replaced with a synthetic sodium silicoaluminate sold under the trademark Zeolex®7. Dusts are prepared by mixing compounds of Formula I, or the enantiomorphs, salts and complexes thereof with finely divided inert solids which can be organic or inorganic in nature. Materials useful for this purpose include botanical flours, silicas, silicates, carbonates and clays. One convenient method of preparing a dust is to dilute a wettable powder with a finely divided carrier. Dust concentrates containing from about 20% to about 80% of the active ingredient are commonly made and are subsequently diluted to from 1% to 10% use concentration. The active compounds can be applied as insecticide sprays by methods commonly employed, such as conventional high-gallonage hydraulic sprays, low gallonage sprays, ultra-low-volume sprays, air blast spray, aerial sprays, and dusts. The present invention also contemplates methods of killing, combating or controlling pests which compromises contacting pests with a combative or toxic amount (i.e. a pesticidally effective amount) of at least one active compound of the invention alone or together with a carrier vehicle (composition or formulation) as noted above. The term contacting as employed in the specification and claims means applying to at least one of (a) such pests and (b) the corresponding habit at thereof (i.e., the locus to be protected, for example, to a growing crop or to an area where a crop is to be grown) the active compound of this invention alone or as a constituent of a composition or formulation. In addition to the aforementioned ingredients the preparations according to the invention may also contain other substances commonly used in preparations of this kind. For example, a lubricant, such as calcium stearate or magnesium stearate, may be added to a wettable powder or to a mixture to be granulated. Furthermore there may, for example, be added adhesives such as polyvinylalcohol-cellulose derivatives or other colloidal materials, such as casein, to improve the adherence of the pesticide to the surface to be protected.

Claims: A compound of the formula: wherein X is N or CH; Y is O, S or NR 8 ; A is selected from the group consisting of hydrogen, halo, cyano, (C 1 -C 12 )alkyl, and (C 1 -C 12 )alkoxy; Z is O, N-OR 9 or N-R 10 ; R 1 and R 8 are independently selected from the group consisting of hydrogen and (C 1 -C 4 )alkyl; R 2 is selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo (C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, cyano, (C 1 -C 4 ) alkoxycarbonyl, aryl, aralkyl, heterocyclic, and heterecyclic(C 1 -C 4 )alkyl; R 3 and R 7 are each independently selected, from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, heterocyclic and heterocyclic(C 1 -C 4 )alkyl, provided that at least one of R 3 and R 7 is aryl, aralkyl, heterocyclic, or heterocyclic(C 1 -C 4 )alkyl; R 4 , R 5 and R 6 are each independently selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo (C 2 -C 8 )alkynyl, halo, cyano, (C 1 -C 4 )alkoxycarbonyl, aryl, aralkyl, heterocyclic and heterocyclic(C 1 -C 4 )alkyl; R 9 is selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo (C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, (C 1 -C 4 )alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclic carbonyl, (C 1 -C 4 )alkoxycarbonyl, aryl, aralkyl, heterocyclic and heterocyclic(C 1 -C 4 )alkyl; R 10 is selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 2 -C 8 )alkenyl, halo (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, heterocyclic or heterocyclic(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylcarbonyl, and (C 1 -C 4 )alkoxycarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclic carbonyl, (C 1 -C 4 ) alkylaminocarbonyl, arylaminocarbonyl, N-R 8 R 9 , N=CR 11 R 12 , (C 1 -C 4 )alkylsulfonyl, N=cyclopropyl, N=cyclobutyl, N=cyclopentyl, N=cyclohexyl, N=benzyl, and arylsulfonyl; R 11 and R 12 are each independently selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 1 -C 12 )alkoxy, halo(C 1 -C 12 )alkoxy, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, cyano, (C 1 -C 4 )alkoxycarbonyl, (C 1 -C 4 )alkylamino, aryl, aralkyl, heterocyclic, and heterocyclic(C 1 -C 4 )alkyl, wherein the term "alkyl" refers to branched or straight-chain alkyl groups, the term "haloalkyl" refers to an alkyl group substituted with 1 to 3 halogen atoms, the term "alkenyl" refers to an ethylenically unsaturated hydrocarbon group, straight or branched, having 1 or 2 ethylenic bonds. the term "haloalkenyl" refers to an alkenyl group substituted with 1 to 3 halogen atoms, the term "alkynyl" refers to an unsaturated hydrocarbon group, straight or branched, having 1 or 2 acetylenic bonds, the term "haloalkynyl" refers to an alkynyl group substituted with 1 to 3 halogen atoms. the term "aryl" refers to a phenyl or naphthyl group which may be substituted with up to 3 substituents independently selected from the group consisting of halogen, cyano, trihalomethyl, phenyl, phenoxy, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkylthio, (C 1 -C 4 )alkylsulfoxide, halo(C 1 -C 4 )alkyl and halo(C 1 -C 4 )alkoxy. the term "heterocyclic" refers to a substituted or unsubstituted 5- or 6-membered unsaturated ring containing 1, 2 or 3 heteroatoms independently selected from oxygen, nitrogen and sulphur, or to a bicyclic unsaturated ring system containing up to 10 atoms including one heteroatom selected from oxygen, nitrogen and sulphur - if the heterocyclic ring is substituted, there may be up to two substituents indpendently selected from (C 1 -C 4 )alkyl, halogen, cyano, nitro, and trihalomethyl, the term "aralkyl" refers to a group having an alkyl chain and an aryl portion, wherein the alkyl chain is from 1 to 10 carbon atoms and can be branched or straight chain, with the aryl portion as defined above, forming a terminal portion of the aralkyl moiety, the term "halogen" or "halo" refers to iodo, fluoro, bromo and chloro moieties. The compound of claim 1 wherein X is CH, Y is O, Z is NOR 9 , R 2 is (C 1 -C 12 )alkyl, and R 3 is H or (C 1 -C 4 )alkyl. The compound of claim 2 wherein R 9 is (C 1 -C 4 ) alkyl and R 7 is selected from the group consisting of phenyl, 2-chlorophenyl, 2-fluorophenyl, 2-trifluoromethylphenyl, 3-chlorophenyl, 3-fluorophenyl, 3-trifluoromethylphenyl, 4-chlorophenyl, 4-fluorophenyl, 4-trifluoromethylphenyl, 2,4-dichlorophenyl. and 2,6-dichlorophenyl. The compound of claim 1 wherein X is N, Y is O or NH, Z is NOR 9 , R 2 is (C 1 -C 12 )alkyl, and R 3 is H or (C 1 -C 4 )alkyl. The compound of claim 4 wherein R 9 is (C 1 -C 4 )alkyl and R 7 is selected from the group consisting of phenyl, 2-chlorophenyl, 2-fluorophenyl, 2-trifluoromethylphenyl, 3-chlorophenyl, 3-fluorophenyl, 3-trifluoromethylphenyl, 4-chlorophenyl, 4-fluorophenyl, 4-trifluoromethylphenyl, 2,4-dichlorophenyl, and 2,6-dichlorophenyl The compound of claim 1 where the compound is N-methyl 2-[2-(5-trans-(2-phenylcyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]-2-methoxyiminoacetamide The compound of claim 1 where the compound is N-methyl 2-[2-(5-trans-(2-(4-chloroghenyl)cyclopropyl)-4-methyl-2,7-dioxa-3,6-diazaocta-3,5-dien-1-yl)phenyl]-2-methoxyiminoacetamide A fungicidal composition for controlling phytopathogenic fungi which comprises an agronomically acceptable carrier and the compound of claim 1 wherein the ratio of the carrier to the compound is between 99:1 and 1:4. A method for controlling phytopathogenic fungi which comprises applying the compound of claim 1 to the locus where control is desired, at a rate of from 0.005 to 50 kilograms per hectare. A method for controlling insects which comprises applying to the insects' habitat the compound of claim 1 at a rate of from 0.005 to 10 kilograms per hectare.

Inventors: NGUYEN DUYAN VUONG, ROSS RONALD JR, SHABER STEVE HOWARD, NGUYEN, DUYAN VUONG, ROSS, RONALD, JR., SHABER, STEVE HOWARD
Applicants: DOW AGROSCIENCES LLC
Application year: 2001
Main classification: C07C251
IPC codes: A01N37, C07C251, A01N53