1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES

Abstract: Novel substituted pyrimido[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.

Description: l,5-DISUBSTITuTED-3,4-DIHYDRO-lH-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES. FIELD OF THE INNENTION This invention relates to a novel group of l,5-disubstituted-3,4-dihydro-lH- 5 pyrimido[4,5-d]pyrimidin-2-one compounds, processes for the preparation thereof, the use thereof in treating CSBP/p38 kinase mediated diseases and pharmaceutical compositions for use in such therapy. BACKGROUND OF THE INNENTION 10 Intracellular signal transduction is the means by which cells respond to extracellular stimuli. Regardless of the nature of the cell surface receptor (e. g. protein tyrosine kinase or seven-transmembrane G-protein coupled), protein kinases and phosphatases along with phopholipases are the essential machinery by which the signal is further transmitted within the cell [Marshall, J. C. Cell , 80, 179-278 (1995)]. 15 Protein kinases can be categorized into five classes with the two major classes being, tyrosine kinases and serine / threonine kinases depending upon whether the enzyme phosphorylates its substrate(s) on specific tyrosine(s) or serine / threonine(s) residues [Hunter, T., Methods in Enzymology (Protein K nase Classification) p. 3, Hunter, T.; Sefton, B. M.; eds. vol. 200, Academic Press; San Diego, 1991]. 20 For most biological responses, multiple intracellular kinases are involved and an individual kinase can be involved in more than one signaling event. These kinases are often cytosolic and can translocate to the nucleus or the ribosomes where they can affect transcriptional and translational events, respectively. The involvement of kinases in transcriptional control is presently much better understood than their effect 25 on translation as illustrated by the studies on growth factor induced signal transduction involving MAP/ERK kinase [Marshall, C. J. Cell , 80, 179 (1995); Herskowitz, I. Cell , 80, 187 (1995); Hunter, T. Cell , 80, 225 (1995); Seger, R., and Krebs, E. G. FASEB J., 726-735 (1995)]. While many signaling pathways are part of cell homeostasis, numerous 30 cytokines (e.g., IL-1 and TNF) and certain other mediators of inflammation (e.g., COX-2, and iNOS) are produced only as a response to stress signals such as bacterial lipopolysaccharide (LPS). The first indications suggesting that the signal transduction pathway leading to LPS-induced cytokine biosynthesis involved protein kinases came from studies of Weinstein [Weinstein, et al, J. Immunol. 151, 3829(1993)] but the 35 specific protein kinases involved were not identified. Working from a similar perspective, Han [Han, et al, Science 265, 808(1994)] identified murine p38 as a kinase which is tyrosine phosphorylated in response to LPS. Definitive proof of the involvement of the p38 kinase in LPS-stimulated signal transduction pathway leading to the initiation of proinflammatory cytokine biosynthesis was provided by the independent discovery of p38 kinase by Lee [Lee; et al, Nature, 372, 739(1994)] as the molecular target for a novel class of anti-inflammatory agents. The discovery of p38 (termed by Lee as CSBP 1 and 2) provided a mechanism of action of a class of anti- inflammatory compounds for which SK&F 86002 was the prototypic example. These compounds inhibited IL-1 and TNF synthesis in human monocytes at concentrations in the low uM range [Lee, et al., Int. J. Immunopharmac. 10(7), 835(1988)] and exhibited activity in animal models which are refractory to cyclooxygenase inhibitors [Lee; et al., Annals N. Y. Acad. Sci.. 696, 149(1993)]. It is now firmly established that CSBP/p38 is a one of several kinases involved in a stress-response signal transduction pathway, which is parallel to and largely independent of the analogous mitogen-activated protein kinase (MAP) kinase cascade. Stress signals, including LPS, pro-inflammatory cytokines, oxidants, UN light and osmotic stress, activate kinases upstream from CSBP/p38 which in turn phosphorylate CSBP/ρ38 at threonine 180 and tyrosine 182 resulting in CSBP/p38 activation. MAPKAP kinase-2 and MAPKAP kinase-3 have been identified as downstream substrates of CSBP/p38 which in turn phosphorylate heat shock protein Hsp 27 (Figure 1). Additional downstream substrates known to be phosphorylated by p38 include kinases (Mnkl/2, MSKl/2 and PRAK) and transcription factors (CHOP, MEF2, ATF2 and CREB). While many of the signaling pathways required for cytokine biosynthesis remain unknown it appears clear that many of the substrates for p38 listed above are involved. [Cohen, P. Trends Cell Biol.. 353-361(1997) and Lee, J. C. et al, Pharmacol. Ther. vol. 82, nos. 2-3, pp. 389-397, 1999]. What is known, however, is that in addition to inhibiting IL-1 and TΝF, CSBP/p38 kinase inhibitors (SK&F 86002 and SB 203580) also decrease the synthesis of a wide variety of pro-inflammatory proteins including, IL-6, IL-8, GM-CSF and COX-2. Inhibitors of CSBP/p38 kinase have also been shown to suppress the TΝF- induced expression of NCAM-1 on endothelial cells, the TΝF-induced phosphorylation and activation of cytosolic PLA2 and the IL-1 -stimulated synthesis of collagenase and stromelysin. These and additional data demonstrate that CSBP/p38 is involved not only cytokine synthesis, but also in cytokine signaling [CSBP/P38 kinase reviewed in Cohen, P. Trends Cell Biol.. 353-361(1997)]. Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) are biological substances produced by a variety of cells, such as monocytes or macrophages. IL-1 has been demonstrated to mediate a variety of biological activities thought to be important in immunoregulation and other physiological conditions such as inflammation [See, e.g., Dinarello et al., Rev. Infect. Disease, 6, 51 (1984)]. The myriad of known biological activities of IL-1 include the activation of T helper cells, induction of fever, stimulation of prostaglandin or collagenase production, neutrophil chemotaxis, induction of acute phase proteins and the suppression of plasma iron levels. There are many disease states in which excessive or unregulated BL-l production is implicated in exacerbating and/or causing the disease. These include rheumatoid arthritis, osteoarthritis, endotoxemia and/or toxic shock syndrome, other acute or chronic inflammatory disease states such as the inflammatory reaction induced by endotoxin or inflammatory bowel disease; tuberculosis, atherosclerosis, muscle degeneration, cachexia, psoriatic arthritis, Reiter's syndrome, rheumatoid arthritis, gout, traumatic arthritis, rubella arthritis, and acute synovitis. Recent evidence also links IL-1 activity to diabetes and pancreatic β cells [review of the biological activities which have been attributed to IL-1 Dinarello, J. Clinical Immunology, 5 (5), 287-297 (1985)]. Excessive or unregulated TNF production has been implicated in mediating or exacerbating a number of diseases including rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, adult respiratory distress syndrome, cerebral malaria, chronic pulmonary inflammatory disease, silicosis, pulmonary sarcoisosis, bone resorption diseases, reperfusion injury, graft vs. host reaction, allograft rejections, fever and myalgias due to infection, such as influenza, cachexia secondary to infection or malignancy, cachexia, secondary to acquired immune deficiency syndrome (AIDS), AIDS, ARC (AIDS related complex), keloid formation, scar tissue formation, Crohn's disease, ulcerative colitis, or pyresis. ϊnterleukin-8 (IL-8) is a chemotactic factor produced by several cell types including mononuclear cells, fibroblasts, endothelial cells, and keratinocytes. Its production from endothelial cells is induced by IL-1, TNF, or lipopolysachharide (LPS). IL-8 stimulates a number of functions in vitro. It has been shown to have chemoattractant properties for neutrophils, T-lymphocytes, and basophils. In addition it induces histamine release from basophils from both normal and atopic individuals as well as lysozomal enzyme release and respiratory burst from neutrophils. IL-8 has also been shown to increase the surface expression of Mac- 1 (CD lib/CD 18) on neutrophils without de novo protein synthesis, this may contribute to increased adhesion of the neutrophils to vascular endothelial cells. Many diseases are characterized by massive neutrophil infiltration. Conditions associated with an increased in IL-8 production (which is responsible for chemotaxis of neutrophil into the inflammatory site) would benefit by compounds, which are suppressive of IL-8 production. IL-1 and TNF affect a wide variety of cells and tissues and these cytokines as well as other leukocyte derived cytokines are important and critical inflammatory mediators of a wide variety of disease states and conditions. The inhibition of these cytokines is of benefit in controlling, reducing and alleviating many of these disease states. Inhibition of signal transduction via CSBP/p38, which in addition to IL-1, TNF and IL-8 described above is also required for the synthesis and/or action of several additional pro-inflammatory proteins (i.e., IL-6, GM-CSF, COX-2, collagenase and stromelysin), is expected to be a highly effective mechanism for regulating the excessive and destructive activation of the immune system. This expectation is supported by the potent and diverse anti-inflammatory activities described for CSBP/p38 kinase inhibitors [Badger, et al, J. Pharm. Exp. Thera. 279 (3): 1453- 1461.(1996); Griswold, et al, Pharmacol. Comm. 7, 323-229 (1996)]. The field of patents and patent applications disclosing compounds useful for the treatment of p38 mediated diseases has expanded rapidly over the last several years. In most instances the central core molecule has been an imidazole, oxazole or pyrazole derivative, such as those disclosed in WO 93/14081; WO 93/14082; WO 95/02591; WO 95/13067; WO 95/31451; WO 99/58523; WO 98/56377; WO 97/16442; WO 99/57101; WO 00/39116; and WO 00/31063. Newer ring systems include cycloalkenyl, pyrimidine, pyrazine, and triazole cores such as WO 00/25791; WO 98/24782; WO 99/17776; WO 00/10563; WO 00/25791; and WO 00/35911; and multi ring systems, such as WO 99/64400; WO 98/22457; WO 00/20402; WO 00/12497; WO 99/61426 and WO 99/58502. However, despite all of this research effort there still remains a need for treatments in this field, for compounds which inhibit the CSBP/p38/RK kinase, and are useful in the treatment of disease mediated thereby. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 demonstrates the p38 kinase cascade. Figure 2 demonstrates a Citric Acid Induced Cough Model. Figure 3 demonstrates an Antigen- or LTD4 - Induced Hypertussive Model in the Guinea Pig Figure 4 demonstrates Effects of Dextromethorphan or Codeine On Citric Acid- Induced Cough in Guinea Pigs. SUMMARY OF THE INNENTION This invention relates to the novel compounds of Formulas (I) to (N) and (la) to (Na), and pharmaceutical compositions comprising a compound of Formula (I) to (N) and (la) to (Na), and a pharmaceutically acceptable diluent or carrier. This invention relates to a method of treating, including prophylaxis, of a CSBP/RK/p38 kinase mediated disease in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formulas (I) to (N) and (la) to (Na). Accordingly, the resent invention provides a compound of Formula (I): wherein Rl is an aryl or heteroaryl ring, which ring is optionally substituted; R2 is hydrogen, C1 _ιo alkyl, C3..7 cycloalkyl, 03.7 cycloalkylCι- 0 alkyl, aryl, arylCι _ιo a -.l yl, heteroaryl, heteroarylCι _;to alkyl, heterocyclic, or a heterocyclylC \ _ \ rjalkyl moiety; and wherein each of these moieties , excluding hydrogen, are optionally substituted; R3 is a C1 _ιo alkyl, C3_7cycloalkyl, C3-.7 cycloalkylC * _- o alkyl, arylC-μio alkyl, heteroarylC * [_ιo alkyl, or heterocyclylCj.iQ alkyl moiety; and wherein each of these moieties are optionally substituted; X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n ΝR 4 Rι 4; or (CH 2 ) n NR 2 R 4 ; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; R4 and Ri 4 are each independently selected from hydrogen, optionally substituted Ci-4 alkyl, optionally substituted aryl, or an optionally substituted arylCi -4alkyl, or R4 and R14 together with the nitrogen to which they are attached form a heterocyclic ring of 5 to 7 members, which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring may be optionally substituted; R6 is hydrogen, C1 -lo alkyl, C3-.7 cycloalkyl, heterocyclyl, heterocyclylC i-ioalkyl, aryl, arylCi _10 alkyl, heteroaryl or a heteroarylCι _io alkyl moiety; and wherein each of these moieties, excluding hydrogen, may be optionally substituted; R9 is hydrogen, C(Z)R6, optionally substituted C1 _ιo alkyl, optionally substituted aryl or optionally substituted arylCi-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. Another aspect of the present invention is the novel compounds of Formula (II) represented by the structure: wherein Rl is an aryl or a heteroaryl ring, which ring may be optionally substituted; R 2 is hydrogen, C-μiQalkyl, C3_7cycloalkyl, C3-.7cycloalkylC1.-10 alkyl, aryl, arylCι_ * ιo alkyl. heteroaryl, heteroarylCi _ιo alkyl, heterocyclic, or a heterocyclylC ι_ 10 alkyl moiety; and wherein each of these moieties, excluding hydrogen, are optionally substituted; R3 is an C1 -.joal yl, C3_7cycloalkyl, C3.7cycloalkylC1-.10 alkyl, aryl, arylCi _ιoalkyl, heteroaryl, heteroarylCι- 0 alkyl, heterocyclic, or a heterocyclylC ι_ 10 alkyl moiety; and wherein each of these moieties are optionally substituted; Y is CR-fc,, C(O), N(R £ j), oxygen, or S(O)m; R * b is hydrogen, Cι_ alkyl, NR C , hydroxy, thio, C χ_ 2 alkoxy, or S(O) m C * _ 2 alkyl; R c is hydrogen or Cι_ alkyl; Rr\ is hydrogen or Cι_ 2 alkyl; X is R 2 , OR 2 , S(O) m R 2 , (CH 2 ) n NR 4 R 14 , or (CH 2 ) n NR 2 R 4 ; m is 0 or an integer having a value of 1 or 2; n is 0 or an integer having a value of 1 to 10; R4 and R14 are each independently selected from hydrogen, optionally substituted Ci-4 alkyl, optionally substituted aryl, or an optionally substituted arylCι_4alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring may be optionally substituted; R6 is hydrogen, Ci-io alkyl, C3-.7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or a heteroarylCi-io alkyl; and wherein each of , these moieties, excluding hydrogen, may be optionally substituted; R9 is hydrogen, C(Z)R6 or optionally substituted Ci-io alkyl, optionally substituted aryl or optionally substituted aryl-Ci-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. Another aspect of the present invention are the novel compounds of Formula (III) represented by the structure: wherein Rl is an aryl, or a heteroaryl ring, which ring may be optionally substituted; R 2 is a heterocyclic or heterocyclicC I_IQ alkyl ring, which is ring is optionally substituted; R 2 ' is a heterocyclic, heterocyclicC I_IQ alkyl, aryl, or heteroaryl ring, which ring is optionally substituted; R3 is an aryl or heteroaryl ring, which ring is optionally substituted; X is R 2 >, OR , S(O) m R 2 or (CH ) n NR4Ri4 ; or (CH ) n NR 2 R4; provided that when X is (CH 2 ) n NR4R14, then R4R14 must form the optionally substituted cyclized ring optionally comprising an oxygen, sulfur or nitrogen moiety; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; R4 and R 14 are independently selected from hydrogen, optionally substituted C1-.4 alkyl, optionally substituted aryl, or optionally substituted arylCi-4 alkyl; or R4 and R 4 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring is optionally substituted; Rβ is hydrogen, Ci-io alkyl, C3-.7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCι_ o alkyl, heteroaryl or a heteroarylCi-io alkyl moiety; and wherein each of these moieties, excluding hydrogen, is optionally substituted; R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl, or optionally substituted arylCi-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. Another aspect of the present invention are the novel compounds of Formula (IN) represented by the structures: wherein Rl is an aryl or a heteroaryl ring, which ring is optionally substituted; R 2 is hydrogen, Cι_ιoalkyl, C3-.7 cycloalkyl, 03.7 cycloalkylCι_ιoalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC ι_ιo alkyl moiety; and wherein each of these moieties, excluding hydrogen, are optionally substituted; R3 is a Cι_ιo alkyl, C 3.7 cycloalkyl, C3-.7 cycloalkylCι_i Q alkyl, aryl, arylCι_ιoalkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC ι_ 10 alkyl moiety; and wherein each of these moieties are optionally substituted; Y is a bond, CR D , C(O), Ν(R^), oxygen, or S(O)m; R , is hydrogen, Cι_ alkyl, NR C , hydroxy, thio, Cι_ 2 alkoxy, S(O) m Cι_ 2 alkyl; R c is hydrogen or Cι_ alkyl; R ( is hydrogen or Cι_ 2 alkyl; X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n NR 4 Rι 4) or (CH 2 ) n NR 2 R 4 ; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; R4 and R14 are each independently selected from hydrogen, optionally substituted C1-.4 alkyl, optionally substituted aryl, or optionally substituted arylCi-4 alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring is optionally substituted; Rβ is hydrogen, Ci_ιo alkyl, C3-.7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or a heteroarylCi-io alkyl moiety, and wherein each of these moieties, excluding hydrogen, is optionally substituted; R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl or an optionally substituted aryl-Cι-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. Accordingly, the present invention also provides for a compound of Formula (N): wherein X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n ΝR4R14, or (CH 2 ) n NR 2 R 4 ; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; Rl is an optionally substituted aryl ring; R 2 is hydrogen, Cι_ιø alkyl, C3.7 cycloalkyl, 03.7 cycloalkylC _ιo alkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC ι_ 10 alkyl moiety; and wherein each of these moieties, excluding hydrogen are optionally substituted; R3 is an optionally substituted aryl ring; R4 and R14 are each independently selected from hydrogen, optionally substituted Ci-4 alkyl, optionally substituted aryl, or optionally substituted aryl-Ci-4 alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring is optionally substituted; R6 is hydrogen, Ci-io alkyl, C3-.7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or a heteroarylCi-io alkyl moiety; and wherein each of these moieties, excluding hydrogen, may be optionally substituted; R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl or an optionally substituted arylCi-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. DETAILED DESCRIPTION OF THE INNENTION The present invention is directed to the novel compounds of Formulas (I) to (V), and Formula (la) to (Na), or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) to (N), and (la) to (Na), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent thereof; and also to the use of these compounds in the treatment or prophylaxis of CSBP mediated diseases in a mammal in need thereof. As will be readily recognized, the difference between compounds of Formula (I) to (N) and (la) to (Na) lie in the unsaturation of the pyrimidine-2-one ring. The respective Ri, R 2 , X and R3 terms are the same for both groups within a formula set, i.e. I and la. For purposes herein, everything applicable to Formula (I) is also applicable to Formula (la), Formula (II) and (Ha), Formula (111) and (Ilia), and Formula (N) and (Na) unless otherwise indicated. It should be noted that compounds of Formula (I), (II), (III) and (N) are all subsets of compounds of Formula (IN). More specifically, the present invention is directed to the novel compounds of Formulas (I) and (la), or pharmaceutically acceptable salts thereof. Suitably, for these compounds of Formula (I) and (la), Ri is an aryl, or a heteroaryl ring, which ring is optionally substituted. The ring may be substituted one or more times, in any ring, suitably 1 to 4 times, preferably 1 to 2 times, independently, by halogen, Cl-4 alkyl, halo-substituted-Ci-4 alkyl, cyano, nitro, (CRιoR2θ)vΝR4Rl4, (CRiθR2θ)vC(Z)NR4Rl4, (CRι 0 R2θ)vC(Z)OR 8 , (CRioR20)vCOR a , (CRi 0 R2θ)vC(O)H, S(O) m R 5j (CRi 0 R2θ)vOR 8 , ZC(Z)Rπ, NRioC(Z)Rι 1, or NRιoS(O)2R7- Preferably the ring is an aryl ring, more preferably phenyl, which ring is unsubstituted or substituted one or more times by halogen, preferably chloro or fluoro, or alkyl, preferably methyl. Suitably, the ring is substituted in the 4-position, and if di-substituted, it is in the 2-,4- position of the phenyl ' ring. Suitably m is 0 or an integer having a value of 1 or 2. Suitably, v is 0 or an integer having a value of 1 or 2. Suitably, Z is oxygen or sulfur. Suitably, R a is -4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-.7 cycloalkyl, C5..7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCι-4 alkyl, heterocyclyl, heterocyclylC 1 -.4 alkyl, (CRioR2θ)vOR7, (CRioR20)vS(O) m R 7 , (CRioR20) V NHS(O) 2 R7, or (CRi 0 R2θ)vNR4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably, R4 and R14 are each independently selected from hydrogen, optionally substituted Ci-6 alkyl, optionally substituted aryl, or an optionally substituted aryl-Ci-6 alkyl, or R4 and R14 together with the nitrogen to which they are attached in NR4R14 substituent may form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring may be optionally substituted. Suitably, R5 is hydrogen, C1-.4 alkyl, C2-4 alkenyl, C2-4 alkynyl or NR4R14, excluding the moieties SR5 (wherein m is 0) being SNR4Ri4 ? S(O)2R5 being SO 2 H (wherein m is 2) and S(O)R5 being SOH, (wherein m is 1). Suitably, R6 is hydrogen, Ci-io alkyl, C3-.7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi_io alkyl, heteroaryl or a heteroarylCi-io alkyl moiety, and wherein each these moieties may be optionally substituted. It is recognized herein that hydrogen can not be substituted and is therefore excluded. Suitably, R7 is Ci-βalkyl, aryl, arylCi-βalkyl, heterocyclic, heterocyclylC ι_6 alkyl, heteroaryl, or a heteroarylCι_6alkyl moiety; and wherein each of these moieties may be optionally substituted. Suitably, R% is hydrogen, C1-.4 alkyl, halo-substituted C1-.4 alkyl, C2-4alkenyl, C2-4 alkynyl, C3-.7 cycloalkyl, C5-.7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1 -.4 alkyl, (CRioR20)tOR7, (CRι 0 R2θ)tS(O) m R 7 , (CRι 0 R20)tNHS(O) 2 R7, or (CRioR2θ)tNR4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclyl alkyl, heteroaryl, and heteroaryl alkyl moieties, may be optionally substituted. Suitably, t is an integer having a value of 1 to 3. Suitably, R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl, or optionally substituted aryl-Ci-4 alkyl. Suitably, Rio and R20 are each independently selected from hydrogen or Cl-4 alkyl. Suitably, Rn is Cl-4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4alkynyl, C3-7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCι_4 alkyl, heterocyclyl, heterocyclylC 1 -4 alkyl, (CRιoR2θ)tOR7, (CRl0R20)tS(O) m R7, (CRioR20)tNHS(O)2R7, or (CRio 2θ)vNR4 l4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably, R3 is a Cι_ιoalkyl, C3-.7 cycloalkyl, C3-.7 cycloalkylCι_ιoalkyl, arylCι_ιo alkyl, heteroarylCι_ιo alkyl, or a heterocyclylC I_IQ alkyl moiety, and wherein each of these moieties may be optionally substituted, independently, one or more times, suitably 1 to 4 times, preferably 1 to 2 times, (in any applicable ring) with Ci-io alkyl, halosubstituted Cι_ιo alkyl, C2_ιoalkenyl, C2_ιoalkynyl, C3.7 cycloalkyl, C3_7cycloalkylCι_ιoalkyl, 05.7 cycloalkenyl, C5.7cycloalkenylC1. 0 alkyl, halogen, (CRιoR 2 θ)nO R 6 > (CRι 0 R2θ) n SH, (CRι 0 R2θ)nS(O) m R7, (CRioR20)nNHS(O) 2 R 7 . (CRι 0 R 2 θ)n R4Rl4> (CRι 0 R 2 θ)nCN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Ri4, (CRi 0 R20)nC(Z)R 6 , (CRι 0 R 2 θ)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRι 0 R 2 0)nC(Z)NR 4 Ri4 ; (CRι 0 R 2 o) n NRlθC(Z)R 6 , (CRι 0 R 2 θ)nNRlθC(=NRιo) NR4R14, (CRιoR 2 θ)nOC(Z)NR 4 Ri4, (CRι 0 R 2 θ)nNRlθC(Z) NR4R14, or (CRιoR 2 θ)n RlθC(Z)OR 7 . Preferably, R3 is an optionally substituted C3..7 cycloalkyl, or arylCι_ιo alkyl, more preferably optionally substituted cyclohexyl, benzyl or phenethyl. Preferably, the ring is unsubstituted or substituted one or more times, independently with halogen, more preferably fluorine, or chlorine, or alkyl, such as methyl. The ring is preferably substituted in the 2-position or di-substituted in the 2-,6- position, more preferably with fluorine, methyl, difluoro, or dimethyl. Suitably, n is 0, or an integer having a value of 1 to 10. Suitably, R2 is hydrogen, Cι_iQalkyl, C 3.7 cycloalkyl, C3-7cycloalkylCι_ιoalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC I_IQ alkyl moiety; and wherein these moieties, excluding hydrogen, may be optionally substituted one or more times, suitably 1 to 4 times, independently (in any applicable ring) with Ci- o alkyl, halo-substituted CI_IQ alkyl, C2_ 10 alkenyl, C2-10 alkynyl, C3_7cycloalkyl, C3_7cycloalkylC _ oalkyl, C5-.7 cycloalkenyl, C5_7cycloalkenylCι_ιoalkyl, halogen, (CRιoR2θ)n OR 6> (CRlO R 2θ)n SH > (CRιoR 2 θ)nS(O) m R 7 , (CRιoR 2 θ)nNHS(O) 2 R 7 , (CRι 0 R2θ)nNR4Rl4> (CRι 0 R 2 0)nCN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Rι 4 , (CRι 0 R 2 θ)nC(Z)R 6 , (CRι 0 R 2 0)nOC(Z)R 6 , (CR 10 R 2 θ)nC(Z)OR 6 , (CRιoR2θ)nC(Z)NR 4 R 14) (CRι 0 R 2 θ)nNRloC(Z)R 6 , (CR 10 R 2 o) n NRioC(=NRιo) NR 4 Rι 4 , (CRioR20)nOC(Z)NR 4 Ri 4 , (CRι 0 R 2 θ) n NRlθC(Z) NR4R14, (CRιoR2θ)n NR 10 (Z)OR7,or a dioxyalkylene group of the formula -O-(CH2) s -O-, wherein s is 1 to 3, preferably s is 2 yielding a 1,3-dioxyethylene moiety. Suitably, X is R2, OR 2 , S(O) m R2 or (CH 2 ) n R4Ri4, or (CH 2 ) n R2R4. Suitably, when X is the group OR2, then R2 is preferably an optionally substituted CI_IQ alkyl, an optionally substituted aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic or heterocyclicalkyl moiety. Preferably, when the R2 moiety is an alkyl it is a substituted or unsubstituted C 1-.5 alkyl, Suitably, the alkyl substituents are as defined herein, but are preferably, halogen, hydroxy, or NR4R14. When R2 is an optionally substituted heterocyclic, or heterocyclic alkyl ring, it is preferably a pyrrolidine, piperidine, piperazine, morpholine ring or a pyrrolidinyl alkyl, piperidinyl alkyl, piperazinyl alkyl, or a morpholinyl alkyl. More preferably, it is a piperidine or an alkyl substituted piperidine, such as N-methyl piperidine. Preferably, when X is the group S(O) m R2, R2 is a substituted or unsubstituted alkyl, aryl or aryl alkyl. Preferably, when X is the group (CH2) n NR4Ri4, n is preferably 0 or 1, more preferably 0. Preferably, if the R4 and R14 moiety cyclize the ring is a 5 or 6 membered ring, such as a pyrrolidine, piperidine, piperazine, or morpholine containing ring, which ring may be optionally substituted. Preferably when R4 or Rl4 is an optionally substituted Cι_6alkyl, which chain may be a straight or branched chain, it is substituted one or more times, suitably 1 to 4 times, preferably 1 or 2 times, with halogen; hydroxy; hydroxy substituted Ci-ioalkyl; Ci-io alkoxy; halosubstituted Ci-io alkoxy; S(O)m Cι_4alkyl, wherein m is 0, 1 or 2; NR4R14, such as amino or mono or -disubstituted Cι_6 alkyl or wherein the R4R14 can cyclize together with the nitrogen to which they are attached to form a 5 to 7 membered ring which optionally contains an additional heteroatom selected from O/N/S; C3_7cycloalkyl; C3_7cycloalkyl C _io alkyl group; halosubstituted Ci-io alkyl, such CF2CF2H, or CF3; optionally substituted aryl, such as phenyl, or an optionally substituted arylalkyl, such as benzyl or phenethyl; and wherein these aryl or arylalkyl moieties may also themselves be substituted one to two times by halogen; hydroxy; hydroxy substituted alkyl; Ci-io alkoxy; S(O) m Cι_4 alkyl; amino, mono & di-substituted C _ alkyl amino, such as in the NR4R14 group; C1-.4 alkyl, or CF3. Preferably, the alkyl chain is branched, such as in t-butyl or isopropyl. More preferably the alkyl chain is substituted one or more times, independently by halogen, hydroxy, amino, or mono or di Cι_4 alkyl substituted amino. Preferably, when X is the group (CH2) n NR2R4, n is preferably 0 or 1, more preferably 0. The R2 moiety is preferably, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heterocyclic, substituted or unsubstituted heterocyclic alkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroarylalkyl. Such groups preferably include imidazole, tetrazole, pyrrolidine, piperidine, piperazine, morpholine, pyrrolidinyl alkyl, piperidinyl alkyl, piperazinyl alkyl, or morpholinyl alkyl. Preferably, when X is the group R2, then R2 is preferably an optionally substituted heteroaryl, such as an imidazole, or tetrazole, or is an optionally substituted heterocyclic ring, such as a pyrrolidine, piperidine, piperazine, or a morpholine ring Another aspect of the present invention is directed to the compounds of Formula (II) and (Ha). Suitably, for compounds of Formula (II) and (Ila), Ri is an aryl or a heteroaryl ring, which ring may be optionally substituted. The ring may be substituted one or more times, in any ring, suitably 1 to 4 times, preferably 1 to 2 times, independently, by halogen, Cl-4 alkyl, halo-substituted-Ci-4 alkyl, cyano, nitro, (CRioR20)vNR4Rl4, (CRi 0 R2θ)vC(Z)NR4Rl4, (CRι 0 R20)vC(Z)OR8, (CRioR20)vCOR a , (CRι 0 R2θ)vC(O)H, S(O) m R 5 , (CRι 0 R2θ)vOR8, ZC(Z)Rπ, NRlθC(Z)Rn, or NRιoS(O)2R7- Preferably the ring is an aryl ring, more preferably phenyl, which ring is unsubstituted or substituted one or more times by halogen, preferably chloro or fluoro, or alkyl, preferably methyl. Suitably, the ring is substituted in the 4-position, and if di-substituted, it is in the 2-,4- position of the phenyl ring. Suitably, v is 0 or an integer having a value of 1 or 2. Suitably, Z is oxygen or sulfur. Suitably, R a is C1-.4 alkyl, halo-substituted C1-.4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3_7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCι_4 alkyl, heterocyclyl, heterocyclylC 1.4 alkyl, (CRιoR2θ)vOR7, (CRlθR2θ)vS(O) m R7, (CRioR20)vNHS(O)2R7, or (CRioR2θ)vNR4Rl4. and wherein the cycloalkyl, C5-7 cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl moiety may be optionally substituted. Suitably, R4 and R14 is each independently selected from hydrogen, optionally substituted Ci-6 alkyl, optionally substituted aryl, or optionally substituted aryl-Ci-6 alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring may be optionally substituted. Suitably, R5 is hydrogen, Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl or NR4R14, excluding the moieties SR5 (wherein m is 0) being SN .Ri4 ; S(O)2R5 being SO2H (wherein m is 2) and S(O)R5 being SOH, (wherein m is 1). Suitably, R6 is hydrogen, Ci-io alkyl, C3-7 cycloalkyl, heterocyclyl, heterocyclyl Cι_ιoalkyl, aryl, arylCi-io alkyl, heteroaryl or a heteroarylCi-io alkyl moiety, and wherein each of these moieties may be optionally substituted (excluding hydrogen). Suitably, R7 is Cι_6alkyl, aryl, arylCi-6alkyl, heterocyclic, heterocyclylC ι_6 alkyl, heteroaryl, or a heteroarylCi-6alkyl; and wherein each of these moieties may be optionally substituted. Suitably, Rδ is hydrogen, C1-.4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-.7 cycloalkyl, C5-.7 cycloalkenyl, aryl, arylCi_4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1.4 alkyl, (CRioR20)tOR7, (CRl0R20)tS(O) m R7, (CRioR2θ)tNHS(O) 2 R7, or (CRioR2θ)tNR4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably, t is an integer having a value of 1 to 3. Suitably, R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl, or optionally substituted aryl-Ci-4 alkyl. Suitably, Rio and R20 are each independently selected from hydrogen or C1-4 alkyl. Suitably, Rn is Cι_4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4alkynyl, C3_7cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1 -4 alkyl, (CRιoR2θ)tOR7, (CRioR20)tS(O) m R7, (CRioR2θ)tNHS(O)2R7, or (CRioR2θ)vNR4Rl4. and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably m is 0 or an integer having a value of 1 or 2. Suitably, X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n NR 4 Rι 4j or (CH 2 ) n NR 2 R4. Suitably, Y is CRb, C(O), N(R,j), oxygen, or S(O)m. Suitably, R D is hydrogen, Cι_2 alkyl, NR C , hydroxy, thio, C alkoxy, S(O) m Cι_ 2 alkyl. Suitably, R c is hydrogen or Cι_ 2 alkyl. Suitably, R^ is hydrogen or Cι_ 2 alkyl. Suitably, R3 is a CI_IQ alkyl, C 3.7 cycloalkyl, C3-.7 cycloalkylCι_ιoalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC i-io alkyl moiety, and wherein each of these moieties may be optionally substituted, independently, one or more times, suitably 1 to 4 times, preferably 1 to 2 times, (in any applicable ring) with Ci-io alkyl, halo-substituted Cι_ιo alkyl, C _IQ alkenyl, C2-10 alkynyl, C3-7 cycloalkyl, C3_7cycloalkylCι_ιo alkyl, 05.7 cycloalkenyl, 05.7 cycloalkenyl CI_IQ alkyl, halogen, (CRι 0 R 20 ) n OR6, (CRι 0 R 2 0)nSH, (CRι 0 R 2 θ)nS(O) m R 7 , (CRιoR 2 θ)nNHS(O) 2 R7, (CRι 0 R 2 θ)n R Rl4> (CRι 0 R 2 θ)nCN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Ri 4 , (CRi 0 R 2 0)nC(Z)R 6 , (CRι 0 R 2 θ)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRι 0 R20)nC(Z)NR 4 Ri4 5 (CRι 0 R 2 θ)nNRlθC(Z)R 6 , NR4R14, (CRιoR 2 θ)nOC(Z)NR 4 Ri4, (CRi 0 R 2 0)nNRl0C(Z) NR 4 Rι 4 , or (CRιoR 2 θ)nNRlθC(Z)OR 7 . Preferably, R3 is an optionally substituted C3-.7 cycloalkyl, aryl, or arylCι_ιo alkyl, more preferably optionally substituted cyclohexyl, phenyl, benzyl or phenethyl. Preferably, the ring is unsubstituted or substituted one or more times, independently with halogen, more preferably fluorine, or chlorine, or alkyl, such as methyl. The ring is preferably substituted in the 2-position or di-substituted in the 2- ,6- position, more preferably with fluorine, methyl, difluoro, or dimethyl. Suitably, n is 0, or an integer having a value of 1 to 10. Suitably, R2 is hydrogen, CI_IQ alkyl, C3_7cycloalkyl, C3_7cycloalkylCι_ιoalkyl, aryl, arylC -io alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC ι_ 10 alkyl moiety; and wherein each of these moieties, excluding hydrogen, may be optionally substituted one or more times, suitably 1 to 4 times, independently (in any applicable ring), with Cι_ o alkyl, halo-substituted Cι_ιo alkyl, C2-10 alkenyl, C 2 _IQ alkynyl, 03.7 cycloalkyl, C3_7cycloalkylCι_ιoalkyl, 05.7 cycloalkenyl, C5-.7 cycloalkenyl C * ι_ιo alkyl, halogen, (CRι 0 R2θ)n°R6> (CRlθ 2θ)n SH > (CRioR20)nS(O) m R 7 , (CRιoR 2 θ)nNHS(O) 2 R7. (CRι 0 R 2 θ)nNR4Rl4> (CRi 0 R 2 0)nCN, (CRιoR 2 θ)nS(O)2NR 4 Ri4, (CRι 0 R 2 θ)nC(Z)R 6 , (CRi 0 R 2 0)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRιoR 2 θ)nC(Z)NR4R 14; (CR 10 R 2 θ)nNRlθC(Z)R 6 , NR4R14, (CRι 0 R20)nOC(Z)NR 4 Ri4, (CRι 0 R 2 θ)nNRlθC(Z) NR4R14, (CRιoR2θ)n NR lθC(Z)OR7, or a dioxyalkylene group of the formula -O-(CH2)s-O-, wherein s is 1 to 3, preferably s is 2 yielding a 1,3-dioxyethylene moiety. Suitably, when X is the group OR2, then R2 is preferably an optionally substituted Cι_ o alkyl, an optionally substituted aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic or heterocyclicalkyl moiety. Preferably, when the R2 moiety is an alkyl it is a substituted or unsubstituted C _ alkyl moiety as defined above. Preferably, the alkyl substituents are independently selected from halogen, (CRι 0 R 2 0)nOR6> or (CRι 0 R 2 θ)nNR4Rl4- When R2 is an optionally substituted heterocyclic or heterocyclic alkyl ring, it is preferably a pyrrolidine, piperidine, piperazine, or morpholine ring, or a pyrrolidinyl alkyl, piperidinyl alkyl, piperazinyl alkyl, or a morpholinyl alkyl ring. More preferably, it is a piperidine or an alkyl substituted piperidine, such as N- methyl piperidine. Prefered substituents include halogen, Cι_ιoal yl, halosubstituted Cι_ι 0 alkyl, (CRι 0 R2θ) n NR4Rl4> (CRιoR2θ)nOR6> and (CRι 0 R2θ) n C(Z)OR 6 . Preferably, when X is the group S(O) m R2, R2 is a substituted or unsubstituted Ci-iøalkyl, aryl or arylalkyl. Preferably, when X is the group (CH2) n NR4R14, n is preferably 0 or 1, more preferably 0. Preferably if the R4 and R14 moiety cyclize the ring is a 5 or 6 membered ring, such as a pyrrolidine, piperidine, piperazine, or morpholine containing ring, which ring may be optionally substituted. Preferably, when R4 or Rl4 is an optionally substituted Ci_6alkyl, which chain may be a straight or branched chain, it is substituted one or more times, suitably 1 to 4 times, preferably 1 or 2 times, with halogen; hydroxy; hydroxy substituted Ci-ioalkyl; Ci-io alkoxy; halosubstituted Ci-io alkoxy; S(O)m Ci-4-Ukyl, wherein m is 0, 1 or 2; NR4R14, such as amino or mono or -disubstituted C1-. alkyl or wherein the R4R14 can cyclize together with the nitrogen to which they are attached to form a 5 to 7 membered ring which optionally contains an additional heteroatom selected from O/N/S; C3_7cycloalkyl; C3.//cycloalkyl Ci-io alkyl group; halosubstituted Ci-io alkyl, such CF2CF2H, or CF3; optionally substituted aryl, such as phenyl, or an optionally substituted arylalkyl, such as benzyl or phenethyl; and wherein these aryl or arylalkyl moieties may also themselves be substituted one to two times by halogen; hydroxy; hydroxy substituted alkyl; Ci-io alkoxy; S(O) m C1-.4 alkyl; amino, mono & di-substituted Cι_6 alkyl amino, such as in the NR4R14 group; Cι_4 alkyl, or CF3. Preferably, the alkyl chain is branched, such as in t-butyl or isopropyl. More preferably the alkyl chain is substituted one or more times, independently by halogen, hydroxy, amino, or mono or di Cι_4 alkyl substituted amino. Preferably, when X is the group (CH2) n NR2R4, n is preferably 0 or 1, more preferably 0. The R2 moiety is preferably, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heterocyclic, substituted or unsubstituted heterocyclic alkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroarylalkyl. Such groups preferably include imidazole, tetrazole, pyrrolidine, piperidine, piperazine, morpholine, and 2-,3- or 4-pyridyl, pyrrolidinyl alkyl, piperidinyl alkyl, piperazinyl alkyl, or morpholinyl alkyl. Preferably, when X is the group R2, then R2 is preferably an optionally substituted heteroaryl, such as an imidazole, or tetrazole, or is an optionally substituted heterocyclic ring, such as a pyrrolidine, piperidine, piperazine, or a morpholine ring Another aspect of the present invention are the novel compounds of Formula (IE) and (ma). Suitably, for compounds of Formula (III) and (Ilia), Ri is an aryl or heteroaryl ring, which ring may be optionally substituted. The ring may be substituted one or more times, in any ring, suitably 1 to 4 times, preferably 1 to times, independently, by halogen, Ci_4 alkyl, halo-substituted-Ci-4 alkyl, cyano, nitro, (CRioR20)vNR4Rl4, (CRι 0 R20)vC(Z)NR4Rl4, (CRιoR2θ)vC(Z)ORg, (CRioR20)vCOR a , (CRioR20)vC(O)H, S(O) m R 5 , (CRi 0 R2θ)vOR8, ZC(Z)Rπ, NRioC(Z)Rn, or NRιoS(O)2R7- Preferably the ring is an aryl ring, more preferably phenyl, which ring is unsubstituted or substituted one or more times by halogen, preferably chloro or fluoro, or alkyl, preferably methyl. Suitably, the ring is substituted in the 4-position, and if di-substituted, it is in the 2-,4- position of the phenyl ring. Suitably m is 0 or an integer having a value of 1 or 2. Suitably, v is 0 or an integer having a value of 1 or 2. Suitably, Z is oxygen or sulfur. Suitably, R a is Cl-4 alkyl, halo-substituted Cι_4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3_7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1 -4 alkyl, (CRιoR2θ)vOR7, (CRioR20)vS(O) m R7, (CRlθR2θ) V NHS(O)2R7, or (CRioR2θ)vNR4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl moieties may be optionally substituted. Suitably, R4 and R14 are each independently selected from hydrogen, optionally substituted Ci-6 alkyl, optionally substituted aryl, or an optionally substituted aryl-Cι_6 alkyl; or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring may be optionally substituted. Suitably, R5 is hydrogen, Cι_4 alkyl, C2-4 alkenyl, C2-4 alkynyl or NR4R14, excluding the moieties SR5 (wherein m is 0) being SNR4Ri4 ; S(O)2R5 being SO2H (wherein m is 2) and S(O)R5 being SOH, (wherein m is 1). Suitably, Rβ is hydrogen, Cι_ιo alkyl, C3-7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or a heteroarylCι_ιo alkyl moiety; and wherein each of these moieties, excluding hydrogen, may be optionally substituted. Suitably, R7 is Cι_6alkyl, aryl, arylCι_6alkyl, heterocyclic, heterocyclylC ι_ 6 alkyl, heteroaryl, or heteroarylCι_6alkyl moiety; and wherein each of these moieties may be optionally substituted. Suitably, Rg is hydrogen, Cl-4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3_7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1.4 alkyl, (CRl0R20)tOR7, (CRl0R20)tS(O) m R7, (CRι 0 R20)tNHS(O) 2 R7, or (CRιoR2θ)tNR4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroaryl alkyl moieties, may be optionally substituted. Suitably, t is an integer having a value of 1 to 3. Suitably, R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl or optionally substituted aryl-Cι_4 alkyl. Suitably, Rio and R20 are each independently selected from hydrogen or Cl-4 alkyl. Suitably, Rn is Ci-4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3_7 cycloalkyl, C5_7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1.4 alkyl, (CRιoR2θ)tOR7, (CRioR20)tS(O) m R7, (CRι 0 R2θ)tNHS(O) 2 R7, or (CRι 0 R2θ)vNR4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. SuitablyX is R 2 » , OR 2 , S(O) m R 2 or (CH 2 ) n R4Ri4 5 or (CH 2 ) n NR2R4; provided that when is X is (CH2) n NR4R14, then R4R14 forms the optionally substituted cyclized ring optionally comprising an oxygen, sulfur or nitrogen moiety as defined herein. Suitably, R3 is an optionally substituted aryl, or optionally substituted heteroaryl moiety. The R3 moieties be optionally substituted one or more times independently with Ci-io alkyl, halo-substituted CI_IQ alkyl, C2-10 alkenyl, C2-10 alkynyl, C3 7 cycloalkyl, C3_7cycloalkylCι_ιo alkyl, 05.7 cycloalkenyl, C5.7 cycloalkenyl Cι_ιo alkyl, halogen, (CRιoR2θ)n OR 6> (CRlθR2θ)n SH > (CRι 0 R20)nS(O) m R 7 , (CRι 0 R 2 θ)n HS(O) 2 R7, (CRι 0 R 2 θ)n R4Rl4> (CRi 0 R 2 0)nCN, (CRι 0 R 2 θ)n S(O) 2 NR 4 R 14 , (CRι 0 R 2 θ)nC(Z)R 6 , (CRι 0 R 2 0)nOC(Z)R 6 , (CRι 0 R 2 θ) n C(Z)OR 6 , (CRι 0 R2θ)nC(Z)NR 4 Ri4 5 (CRι 0 R 2 θ)nNRioC(Z)R 6 , (CRι 0 R 2 θ)nNRlθC(=NRιo) NR4R14, (CRι 0 R20)nOC(Z)NR 4 Ri4, (CRι 0 R 2 θ)nNRlθC(Z) NR4R14, or (CRι 0 R2θ)nNRlθC(Z)OR 7 . Preferably, R3 is an optionally substituted aryl, more preferably optionally substituted phenyl. Preferably, the ring is unsubstituted or substituted one or more times, independently with halogen, more preferably fluorine, or chlorine, or alkyl, such as methyl. The ring is preferably substituted in the 2-position or di-substituted in the 2-,6- position, more preferably with fluorine, methyl, difluoro, or dimethyl. Suitably, n is 0, or an integer having a value of 1 to 10. Suitably, R2 is a heterocyclic, or heterocyclylC ι_ιo alkyl ring, which ring or rings(s) are optionally substituted one or more times, suitably 1 to 4, independently with Ci-io alkyl, halo-substituted Cι_ιo alkyl, C2-10 alkenyl, C 2 _ιo alkynyl, C3.7 cycloalkyl, C3_7cycloalkylC _ιo alkyl, C5-.7 cycloalkenyl, C5-7 cycloalkenyl Cι_ιo alkyl, halogen, (CRι 0 R 2 o)nOR 6 , (CRι 0 R 2 θ)nSH, (CRιoR 2 θ)nS(O) m R 7 , (CRιoR 2 θ)nNHS(O) 2 R 7 , (CRι 0 R 2 o) n R4Rl (CRιoR 2 θ)nCN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Rι 4 , (CRι 0 R 2 θ)nC(Z)R 6 , (CRι 0 R 2 θ)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRιoR 2 θ)nC(Z)NR 4 Ri4 ; (CRι 0 R 2 θ)nNRlθC(Z)R 6 , NR4R14, (CRioR20)nOC(Z)NR 4 Ri 4 , (CRι 0 R 2 θ)n RlθC(Z) NR4R14, (CRι 0 R2θ)n NR lθC(Z)OR7, or a dioxyalkylene group of the formula -O-(CH2) s -O-, wherein s is 1 to 3, preferably s is 2 yielding a 1 ,3-dioxyethylene moiety. Suitably, R2'is a heterocyclic, heterocyclylC I_IQ alkyl, aryl, or heteroaryl ring, which ring or rings(s) are optionally substituted one or more times, suitably 1 to 4 times, in any ring, independently with C 1 _ 10 alkyl, halo-substituted C\. Q alkyl, C2_ 10 alkenyl, C2_ 10 alkynyl, 03.7 cycloalkyl, C3_7cycloalkylCι_ιo alkyl, 05.7 cycloalkenyl, C5-7 cycloalkenyl Cχ_ιo alkyl, halogen, (CRιoR2θ)n OR 6> (CRlO R 2θ)n SH > (CRι 0 R 2 0)nS(O) m R 7 , (CRιoR2θ)nNHS(O) 2 R 7 , (CRι 0 R2θ) n NR4Rl4> (CRι 0 R 2 0) n CN, (CRι 0 R 2 0)n S(O) 2 NR 4 Rι 4 , (CRιoR 2 θ)nC(Z)R 6 , (CRι 0 R 2 0)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRι 0 R2θ)nC(Z)NR 4 Rι 4j (CRι 0 R 2 θ)nNRlθC(Z)R 6 , NR4R14, (CRioR20)nOC(Z)NR 4 Ri 4 , (CRι 0 R 2 θ)n RlθC(Z) NR4R14, (CRιoR2θ)n NR 10 c (Z)OR7, or a dioxyalkylene group of the formula -O-(CH2) s -O-, wherein s is 1 to 3, preferably s is 2 yielding a 1,3-dioxyethylene moiety. Suitably, the optionally substituted R2 or R2' heterocyclic ring is a pyrrolidine, piperidine, piperazine, or morpholine ring or a pyrrolidinyl alkyl, piperidinyl alkyl, piperazinyl alkyl, or a morpholinyl alkyl. More preferably, it is a piperidine or an alkyl substituted piperidine, such as N-methyl piperidine. Suitably, when R2' is an optionally substituted aryl or heteroaryl ring, the ring is an optionally substituted phenyl, imidazole or tetrazole ring. Another aspect of the present invention is the novel compounds of Formula (IV) and (INa). Suitably, for compounds of Formula (rV) and (INa), R is an aryl or heteroaryl ring, which ring is optionally substituted. The ring may be substituted one or more times, in any ring, suitably 1 to 4 times, preferably 1 to 2 times, independently, by halogen, Cι_4 alkyl, halo-substituted-Ci-4 alkyl, cyano, nitro, (CRioR20)vNR4Rl4, (CRι 0 R20)vC(Z)NR4Rl4. (CRioR2θ)vC(Z)OR 8 , (CRioR20)vCOR a , (CRioR20)vC(O)H, S(O) m R 5 , (CRi 0 R2θ)vOR8, ZC(Z)Rn, NRioC(Z)Rι i, or NRιoS(O)2R7- Preferably the ring is an aryl ring, more preferably phenyl, which ring is unsubstituted or substituted one or more times by halogen, preferably chloro or fluoro, or alkyl, preferably methyl. Suitably, the ring is substituted in the 4-position, and if di-substituted, it is in the 2-,4- position of the phenyl ring. Most preferably Ri is a 2-methyl-4-fluoro phenyl. Suitably m is 0 or an integer having a value of 1 or 2. Suitably, v is 0 or an integer having a value of 1 or 2. Suitably, Z is oxygen or sulfur. Suitably, R a is Cι_4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, 03.7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1.4 alkyl, (CRιoR2θ)vOR7, (CRioR20)vS(O) m R7, (CRioR20) V NHS(O)2R7, or (CRioR20)vNR4Rl4. and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl moieties may be optionally substituted. Suitably, R4 and R14 are each independently selected from hydrogen, optionally substituted Ci-6 alkyl, optionally substituted aryl or an optionally substituted aryl-Ci-6 alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring may be optionally substituted. Suitably, R5 is hydrogen, Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl or NR4R14, excluding the moieties SR5 (wherein m is 0) being SNR4Ri4 ; S(O)2R5 being SO2H (wherein m is 2) and S(O)R5 being SOH, (wherein m is 1). Suitably, R6 is hydrogen, Cι_ιo alkyl, C3-7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or heteroarylCi_lo alkyl; and wherein each of these moieties, excluding hydrogen, may be optionally substituted. Suitably, R7 is Ci_6alkyl, aryl, arylCi_6alkyl, heterocyclic, heterocyclylC ι_6 alkyl, heteroaryl, or heteroarylCi-6alkyl; and wherein each of these moieties may be optionally substituted. Suitably, Rδ is hydrogen, Cl-4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-7 cycloalkyl, Cs_7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1.4 alkyl, (CRι 0 R20)tOR7, (CRι 0 R20)tS(O) m R7, (CRι 0 R2θ)tNHS(O) 2 R7, or • (CRioR20)t R4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclyl alkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably, t is an integer having a value of 1 to 3. Suitably, R9 is hydrogen, C(Z)R6, optionally substituted -io alkyl, optionally substituted aryl or optionally substituted aryl-Cι_4 alkyl. Suitably, Rio and R20 are each independently selected from hydrogen or Cl-4 alkyl. Suitably, Rn is Cl-4 alkyl, halo-substituted Cl-4 alkyl, C 2 -4 alkenyl, C 2 -4 alkynyl, 03.7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1 -4 alkyl, (CRioR2θ)tOR7, (CRioR20)tS(O) m R7, (CRιoR2θ)tNHS(O) 2 R7, or (CRι 0 R2θ)vNR4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably, R3 is hydrogen, an CI_IQ alkyl, C3..7 cycloalkyl, C3_7cycloalkylCι_ιoalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC I_IQ alkyl moiety; and wherein each of these moieties, excluding hydrogen, may be optionally substituted, independently, one or more times, suitably 1 to 4 times, preferably 1 to 2 times, in any ring if applicable, with Ci-io alkyl, halo-substituted CI_IQ alkyl, C2-10 alkenyl, C2-10 alkynyl, C3..7 cycloalkyl, C3_7cycloalkylC _ιo alkyl, C5-7 cycloalkenyl, C5-.7 cycloalkenyl CI_IQ alkyl, halogen, (CRι 0 R 2 θ) OR6> (CR^O^SH, (CRι 0 R 2 θ)nS(O) m R 7 , (CRι 0 R20)nNHS(O) 2 R 7 , (CRιoR2θ)n R4 l4, (CRlθR2θ) n CN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Ri 4 , (CRi 0 R 2 0)nC(Z)R 6 , (CRι 0 R 2 θ)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRι 0 R20)nC(Z)NR 4 Ri4 5 (CRιoR 2 θ)n RlθC(Z)R 6 , NR4R14, (CRι 0 R2θ)nOC(Z)NR 4 Ri4, (CRi 0 R 2 o)nNRloC(Z) NR4R14, or (CRιoR 2 θ)n RlθC(Z)OR 7 . Preferably, R3 is an optionally substituted Cι_ιoalkyl, aryl, arylCι_ιoalkyl, or a cycloalkyl moiety, more preferably optionally substituted C1-.5 alkyl, cyclohexyl, phenyl, benzyl or phenethyl. Preferably, the ring is unsubstituted or substituted one or more times, independently with halogen, more preferably fluorine, or chlorine, or alkyl, such as methyl. The ring is preferably substituted in the 2- position or di-substituted in the 2-,6- position, more preferably with fluorine, methyl, difluoro, or dimethyl. Suitably, X is R 2 , OR 2 , S(O) m R 2 , (CH 2 ) n NR 4 Rι 4; or (CH 2 ) n NR 2 R4- Suitably, R2 is hydrogen, C1 0 alkyl, C3-.7 cycloalkyl, C3-.7 cycloalkylC 1 _ 1 oalkyl, aryl, arylC _\Q alkyl, heteroaryl, heteroarylC 1 _ 1 Q alkyl, heterocyclic, or a heterocyclylC ι_ιo alkyl moiety; and wherein each of these moieties, excluding hydrogen, may optionally substituted one or more times, suitable 1 to 4 times, independently, and in any ring, with Ci-io alkyl, halo-substituted CI_IQ alkyl, C2-10 alkenyl, C2-10 alkynyl, C^χ cycloalkyl, C3-.7cycloalkylC1-.10 alkyl, 05.7 cycloalkenyl, C 5 _ 7 cycloalkenyl C io alkyl, halogen, (CRι 0 R2θ)nOR6> (CRioR2θ)nSH, (CRι 0 R 2 0)nS(O) m R 7 , (CRι 0 R2θ)nNHS(O) 2 R 7 , (CRι 0 R2θ)n R 4 Rl4, (CRi 0 R 2 o)nCN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Rι 4 , (CRιoR 2 θ)nC(Z)R 6 , (CRi 0 R 2 0)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRι 0 R2θ)nC(Z)NR 4 Ri4 5 (CRι 0 R 2 θ)nNRlθC(Z)R 6 , NR4R14, (CRioR20)nOC(Z)NR 4 Ri 4 , (CRι 0 R 2 θ)nNRlθC(Z) NR4R14, (CRιoR2θ)n NR lθC(Z)OR7, or a dioxyalkylene group of the formula -O-(CH2)s-O-, wherein s is 1 to 3, preferably s is 2 yielding a 1,3-dioxyethylene moiety. Suitably, n is 0, or an integer having a value of 1 to 10. Suitably, when X is the group OR2, then R2 is preferably an optionally substituted CI_IQ alkyl, an optionally substituted aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic or heterocyclicalkyl moiety. Preferably, when the R2 moiety is an alkyl it is a substituted or unsubstituted C _ alkyl. Suitably, the alkyl substituents are halogen, (CRι 0 R2θ)nOR6> (CRioR2θ) n SH, (CRι 0 R2θ)nS(O) m R 7 , (CRι 0 R20)nNHS(O) 2 R 7 , (CRι 0 R2θ)n R 4 Rl (CRι 0 R 2 θ)nCN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Ri 4 , (CRi 0 R 2 0)nC(Z)R 6 , (CRι 0 R 2 θ)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRι 0 R2θ)nC(Z)NR 4 Ri4 5 (CRιoR2θ)n RlθC(Z)R 6 , (CRι 0 R 2 θ)nNRlθC(=NRιo) NR4R14, (CRιoR 2 θ)nOC(Z)NR 4 Ri4, (CRι 0 R 2 θ)nNRloC(Z) NR4R14, or (CRι 0 R 2 θ)nNRlθC(Z)OR 7 . Preferably, the alkyl substituents are halogen, (CRιoR 2 θ)nOR6> or (CRi 0 R20)n R4Rl4- When R2 is an optionally substituted heterocyclic or heterocyclic alkyl ring, it is preferably a pyrrolidine, piperidine, piperazine, or morpholine ring, or is a pyrrolidinyl alkyl, piperidinyl alkyl, piperazinyl alkyl, or morpholinyl alkyl ring. More preferably, it is a piperidine or an alkyl substituted piperidine, such as N- methyl piperidine. Prefered substituents include halogen, Cι_ι oalkyl, halosubstituted Cι_ 10 alkyl, (CRι 0 R 2 θ)n R4Rl4> (CRι 0 R2θ)nO 6, and (CRι 0 R 2 θ)nC(Z)OR 6 . Preferably when X is the group S(O) m R2, R2 is a substituted or unsubstituted Cι_ιoalkyl, aryl or arylalkyl. While the X group S(O) m R2 moiety is a compound of Formula (IN) it is also a key intermediate in the process of making other compounds of Formula (IV) as can be seen by Scheme I herein. Preferably for this use, m is 0 and R2 is a short chain alkyl, such as methyl. Preferably, when X is the group (CH2) n ΝR4R14, n is preferably 0 or 1, more preferably 0. Preferably, if the R4 and R14 moiety cyclize the ring is a 5 or 6 membered ring, such as a pyrrolidine, piperidine, piperazine, or morpholine containing ring, which ring may be optionally substituted. Preferably, when R4 or R14 is an optionally substituted Ci-βalkyl, which chain may be a straight or branched chain, it is substituted one or more times, independently, suitably 1 to 4 times, preferably 1 or 2 times, with halogen; hydroxy; hydroxy substituted Ci- lOalkyl; Cι_ιo alkoxy; halosubstituted Ci-io alkoxy; S(O)m C ^alkyl, wherein m is 0, 1 or 2; NR4R14, such as amino or mono or -disubstituted Cι_4 alkyl or wherein the R4R14 can cyclize together with the nitrogen to which they are attached to form a 5 to 7 membered ring which optionally contains an additional heteroatom selected from O/N/S; C3_7cycloalkyl; C3_7cycloalkyl -io alkyl group; halosubstituted Ci-io alkyl, such CF2CF2H, or CF3; optionally substituted aryl, such as phenyl, or an optionally substituted arylalkyl, such as benzyl or phenethyl; and wherein these aryl or arylalkyl moieties may also themselves be substituted one to two times by halogen; hydroxy; hydroxy substituted alkyl; Cι_ιo alkoxy; S(O) m C1.4 alkyl; amino, mono & di-substituted C -4 alkyl amino, such as in the NR4R14 group; Cl-4 alkyl, or CF3. Preferably, the alkyl chain is branched, such as in t-butyl or isopropyl. More preferably the alkyl chain is substituted one or more times, independently by halogen, hydroxy, amino, or mono or di C1.4 alkyl substituted amino. Preferably, when X is the group (CH 2 ) n NR 2 R4, n is preferably 0 or 1, more preferably 0. Preferably one of R 2 or R4 is hydrogen and the other is an optionally substituted moiety. The R moiety is preferably, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heterocyclic, substituted or unsubstituted heterocyclic alkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroarylalkyl. When R 2 is an optionally substitued heterocyclic, heterocyclic alkyl, or heteroaryl group such groups are preferably an imidazole, tetrazole, pyrrolidine, piperidine, piperazine, morpholine and 2-, 3- or 4- pyridyl; pyrrolidinyl alkyl, piperidinyl alkyl, piperazinyl alkyl, or morpholinyl alkyl. When the R 2 moiety is an optionally substituted Ci-io alkyl, the chain may be straight or branched, and substituted one or more times, suitably 1 to 4 times, independently by halogen, (CRιoR2θ)nOR6> ( R lθR2θ) n SH, (CRι 0 R2θ)nS(O) m R 7 , (CRl 0 R20)nNHS(O) 2 R 7 , (CRι 0 R 2 θ) n R4Rl4> (CRι 0 R2θ) n CN, (CRιoR 2 θ)nS(O)2NR 4 Ri4, (CRι 0 R 2 θ)nC(Z)R 6 , (CRι 0 R 2 θ)nOC(Z)R 6 , (CRι 0 R 2 o)nC(Z)OR 6 , (CRιoR2θ)nC(Z)NR 4 Rι 4; (CRι 0 R 2 θ)nNRlθC(Z)R 6 , NR4R14, (CR 10 R2θ)nOC(Z)NR 4 Ri4, (CRι 0 R2θ)n NR lθC(Z) NR4R14, (CR 10 R2θ)nNRlθC(Z)OR 7 , or dioxyalkylene group of the formula -O-(CH2)s-O-, wherein s is 1 to 3, preferably s is 2 yielding a 1,3- dioxyethylene moiety. Preferably, when X is the group R2, then R2 is preferably an optionally substituted heteroaryl, such as an imidazole, or tetrazole, or is an optionally substituted heterocyclic ring, such as a pyrrolidine, piperidine, piperazine, or morpholine ring. Suitably, Y is a bond, CR D , C(O), N(Rd), oxygen, or S(O)m. Preferably Y is a bond. Suitably, Rtø is hydrogen, C _ 2 alkyl, NR C , hydroxy, thio, Cι_2 alkoxy, S(O) m Ci- 2 alkyl. Suitably, R c is hydrogen or C j_ 2 alkyl. Suitably, R^ is hydrogen or C _ 2 alkyl. Suitably, m is 0 or an integer having a value of 1 or 2. Another aspect of the present invention is the novel compounds of Formula (V) and (Na). Suitably, for compounds of Formula (N) and (Na), Ri is an optionally substituted aryl ring, preferably a phenyl ring. The phenyl or napthyl ring or ring(s) may be substituted one or more times, in any ring, preferably 1 to 4 times, independently, by substituents selected from halogen, Cl-4 alkyl, halo-substituted- Cι_4 alkyl, cyano, nitro, (CRιoR2θ)vΝR4Rl4, (CRιoR2θ)vC(Z)NR4Rl4, (CRioR20)vC(Z)OR 8 , (CRι 0 R20)vCOR a , (CRι 0 R2θ)vC(O)H, S(O) m R 5 , (CRioR20)vOR8, ZC(Z)Ri 1, NRιoC(Z)Rι 1, or NRloS(O) 2 R7. Preferably the ring is unsubstituted or substituted one or more times by halogen, preferably chloro or fluoro, or alkyl, preferably methyl. Suitably, the ring is substituted in the 4-position, and if di-substituted, in the 2-,4- position of the phenyl ring. Suitably, v is 0 or an integer having a value of 1 or 2. Suitably, Z is oxygen or sulfur. Suitably, R a is Cl-4 alkyl, halo-substituted Cl-4 alkyl, C 2 -4 alkenyl, C2-4 alkynyl, C3-7 cycloalkyl, C5_7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC \ .4 alkyl, (CRιoR2θ)vOR7, (CRioR20)vS(O) m R7, (CRιoR2θ)vNHS(O)2R7, or (CRlθR2θ)v R4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclyl alkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably, R4 and R14 is each independently selected from hydrogen, optionally substituted Ci-6 alkyl, optionally substituted aryl or optionally substituted aryl-Ci-6 alkyl, or together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, which ring may be optionally substituted. Suitably, R5 is hydrogen, Cι_4 alkyl, C2-4 alkenyl, C2-4 alkynyl or NR4R14, excluding the moieties SR5 (wherein m is 0) being SNR4R14, S(O)2R5 being SO2H (wherein m is 2) and S(O)R5 being SOH, (wherein m is 1). Suitably, R6 is hydrogen, Ci-io alkyl, C3_7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or heteroarylC -io alkyl; and wherein each of these moieties, excluding hydrogen, may be optionally substituted. Suitably, R7 is Ci-6alkyl, aryl, arylCi-galkyl, heterocyclic, heterocyclylC \-6 alkyl, heteroaryl, or heteroarylCι_6alkyl; and wherein each of these moieties may be optionally substituted. Suitably, R 8 is hydrogen, Cι_4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C 2 _4 alkynyl, C3-7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1 -4 alkyl, (CRioR20)tOR7, (CRlθR2θ)tS(O) m R 7 , (CRι 0 R2θ)tNHS(O)2R7, or (CRioR2θ)tNR4Rl4; and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclyl alkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably, t is an integer having a value of 1 to 3. Suitably, R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl or optionally substituted aryl-Ci-4 alkyl. Suitably, Rio and R20 are each independently selected from hydrogen or Cl-4 alkyl. Suitably, Rn is Cl-4 alkyl, halo-substituted Cl-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4 alkyl, heterocyclyl, heterocyclylC 1 -4 alkyl, (CRιoR2θ)tOR7, (CRl0R20)tS(O) m R 7 , (CRloR20)tNHS(O)2R7, or (CRioR2θ)vNR4Rl4. and wherein the alkyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroaryl alkyl moieties may be optionally substituted. Suitably m is 0 or an integer having a value of 1 or 2. Suitably, R2 is hydrogen, CI_IQ alkyl, C 3.7 cycloalkyl, C3_7cycloalkylCι_ιoalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC I_IQ alkyl moiety; and wherein each of these moieties, excluding hydrogen, may optionally substituted one or more times independently, preferably 1 to 2 times, with Ci_ιo alkyl, halo-substituted CI_IQ alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-.7 cycloalkyl, C3_7cycloalkylCι_ιo alkyl, C5.7 cycloalkenyl, 05.7 cycloalkenyl Cι_ιo alkyl, halogen, (CRι 0 R 2 0)nO 6, (CRι 0 R 2 θ)nSH, (CRι 0 R2θ)nS(O) m R 7 , (CRιoR 2 θ)nNHS(O) 2 R7, (CRι 0 R 2 0)nNR4Rl4 5 (CRι 0 R2θ) n CN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Rι 4 , (CRi 0 R 2 0)nC(Z)R 6 , (CRι 0 R2θ) n OC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRιoR2θ)nC(Z)NR 4 Ri4 5 (CRιoR2θ)nNRlθC(Z)R6, NR4R14, (CRi 0 R20)nOC(Z)NR 4 Ri4, (CRι 0 R 2 θ)n RlθC(Z) NR4R14, (CRιoR2θ)n N RlθC(Z)OR7, or a dioxyalkylene group of the formula -O-(CH2)s~O-, wherein s is 1 to 3, preferably s is 2 yielding a 1,3-dioxyethylene moiety. Suitably, R3 is an optionally substituted aryl ring, which ring may be optionally substituted one or more times, independently, in any ring, with Ci-io alkyl, halo-substituted C _ιø alkyl, C2-10 alkenyl, C2-10 alkynyl, C3.7 cycloalkyl, C3_7cycloalkylCi_io alkyl, 05.7 cycloalkenyl, 05.7 cycloalkenyl CI_IQ alkyl, halogen, (CRι 0 R2θ) n OR6, (CRι 0 R2θ)nSH, (CRι 0 R2θ)nS(O) m R 7 , (CR 10 R 2 o)nNHS(O)2R7, (CR 10 R 2 θ) n NR4 l4> (CRι 0 R 2 θ)nCN, (CRι 0 R 2 θ)n S(O) 2 NR 4 Ri 4 , (CRi 0 R 2 0)nC(Z)R 6 , (CRι 0 R 2 θ)nOC(Z)R 6 , (CRι 0 R 2 θ)nC(Z)OR 6 , (CRι 0 R2θ)nC(Z)NR4Rι 4) (CRιoR2θ)n RlθC(Z)R6, NR 4 R M , (CRι 0 R2θ)nOC(Z)NR 4 Ri4, (CRι 0 R 2 θ)nNRlθC(Z) NR4R14, or (CRιoR 2 θ)nNRlθC(Z)OR 7 . Preferably, R3 is an optionally substituted phenyl. Preferably, the ring is unsubstituted or substituted one or more times, independently with halogen, more preferably fluorine, or chlorine, or alkyl, such as methyl. The ring is preferably substituted in the 2-position or di-substituted in the 2-,6- position, more preferably with fluorine, methyl, difluoro, or dimethyl. Suitably, n is 0, or an integer having a value of 1 to 10. Suitably, X is R 2 , OR 2 , S(O) m R 2 , (CH 2 ) n NR 4 Rι 4j or (CH 2 ) n NR 2 R4- Suitably, when X is the group OR2, then R2 is preferably an optionally substituted CI_I Q alkyl, an optionally substituted aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclic or heterocyclicalkyl moiety. Preferably, when the R2 moiety is an alkyl it is a substituted or unsubstituted C \_β alkyl moiety. Preferably, the alkyl substituents are independently selected from halogen, (CRιoR2θ)n -R6 > or (CRi 0 R 20 ) n NR4Rl4- When R 2 is an optionally substituted heterocyclic or heterocyclic alkyl ring, it is preferably a pyrrolidine, piperidine, piperazine, or morpholine ring, or a pyrrolidinyl alkyl, piperidinyl alkyl, piperazinyl alkyl, or a morpholinyl alkyl ring. More preferably, it is a piperidine or an alkyl substituted piperidine, such as N- methyl piperidine. Prefered substituents include halogen, Cι_iQalkyl, halosubstituted Cι_ι 0 alkyl, (CRι 0 R 2 θ)n R4Rl4> (CRι 0 R2θ)nOR6, and (CRι 0 R 2 θ)nC(Z)OR 6 . Preferably when X is the group S(O) m R2, and R2 is a substituted or unsubstituted Cι_ιoalkyl, aryl or arylalkyl. Preferably, when X is the group (OHNJn NR4R14, n is preferably 0 or 1, more preferably 0. Preferably if the R4 and R14 moiety cyclize the ring is a 5 or 6 membered ring, such as a pyrrolidine, piperidine, piperazine, or morpholine containing ring, which ring may be optionally substituted. Preferably, when R4 or R14 is an optionally substituted Ci_6alkyl, which chain may be a straight or branched chain, it is substituted one or more times, suitably 1 to 4 times, preferably 1 or 2 times, with halogen; hydroxy; hydroxy substituted Cι_ιoalkyl; Ci-io alkoxy; halosubstituted Ci-io alkoxy; S(O)m Ci^alkyl, wherein m is 0, 1 or 2; NR4R14, such as amino or mono or -disubstituted Cι_6 alkyl or wherein the R4R14 can cyclize together with the nitrogen to which they are attached to form a 5 to 7 membered ring which optionally contains an additional heteroatom selected from O/N/S; C3_7cycloalkyl; C3 ^cycloalkyl Ci-io alkyl group; halosubstituted Ci-io alkyl, such CF 2 CF 2 H, or CF3; optionally substituted aryl, such as phenyl, or an optionally substituted arylalkyl, such as benzyl or phenethyl; and wherein these aryl or arylalkyl moieties may also themselves be substituted one to two times by halogen; hydroxy; hydroxy substituted alkyl; Cι_ιo alkoxy; S(O) m C1.4 alkyl; amino, mono & di-substituted C _ alkyl amino, such as in the NR4R14 group; Cι_4 alkyl, or CF3. Preferably, the alkyl chain is branched, such as in t-butyl or isopropyl. More preferably the alkyl chain is substituted one or more times, independently by halogen, hydroxy, amino, or mono or di Ci-4 alkyl substituted amino. Preferably, when X is the group (CH 2 ) n NR 2 R4, n is preferably 0 or 1, more preferably 0. The R 2 moiety is preferably, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heterocyclic, substituted or unsubstituted heterocyclic alkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroarylalkyl. Such groups preferably include morpholinoethyl, pyrroleethyl, piperidineethyl, pyridylethyl, or piperidine. Preferably, when X is the group R2, then R2 is preferably an optionally substituted heteroaryl, such as an imidazole, or tetrazole, or an optionally substituted heterocyclic ring, such as a pyrrolidine, piperidine, piperazine, or a morpholine ring As used herein, "optionally substituted" unless specifically defined shall mean, substituent groups which may be substituted on the applicable moiety one or more times, independently, by halogen, such as fluorine, chlorine, bromine or iodine; hydroxy; hydroxy substituted Ci-ioalkyl; Ci-io alkoxy, such as methoxy or ethoxy; halosubstituted Ci-io alkoxy; S(O)m alkyl, wherein m is 0, 1 or 2, such as methyl thio, methylsulfinyl or methyl sulfonyl; NR4R14, such as amino or mono or -disubstituted C1.4 alkyl or wherein the R4R14 can cyclize together with the nitrogen to which they are attached to form a 5 to 7 membered ring which optionally contains an additional heteroatom selected from O/N/S; Ci-io alkyl, C3-7cycloalkyl, or C3_7cycloalkyl Ci-io alkyl group, such as methyl, ethyl, propyl, isopropyl, t-butyl, etc. or cyclopropyl methyl; halosubstituted Ci-io alkyl, such CF2CF2H, or CF3; optionally substituted aryl, such as phenyl, or an optionally substituted arylalkyl, such as benzyl or phenethyl; and wherein the aryl or arylalkyl moieties may also themselves be substituted one to two times by halogen; hydroxy; hydroxy substituted alkyl; Ci-io alkoxy; S(O) m alkyl; amino, mono & di-substituted C1.4 alkyl amino, such as in the NR4R14 group; C1-.4 alkyl, or CF3. Suitable pharmaceutically acceptable salts are well known to those skilled in the art and include basic salts of inorganic and organic acids, such as hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, methane sulphonic acid, ethane sulphonic acid, acetic acid, malic acid, tartaric acid, citric acid, lactic acid, oxalic acid, succinic acid, fumaric acid, maleic acid, benzoic acid, salicylic acid, phenylacetic acid and mandelic acid. In addition, pharmaceutically acceptable salts of compounds of Formulas (I) to (rV) may also be formed with a pharmaceutically acceptable cation, for instance, if a substituent group comprises a carboxy moiety. Suitable pharmaceutically acceptable cations are well known to those skilled in the art and include alkaline, alkaline earth, ammonium and quaternary ammonium cations. The term "halo" or "halogens" is used herein to mean the halogens, chloro, fluoro, bromo and iodo. The term "Cι_ιoalkyl" or "alkyl" or "alkyl _ιo" is used herein to mean both straight and branched chain radicals of 1 to 10 carbon atoms, unless the chain length is otherwise limited, including, but not limited to, methyl, ethyl, 72-propyl, iso- propyl, «-butyl, see-butyl, iso-butyl, tert-butyl, n-pentyl and the like. The term "cycloalkyl" is used herein to mean cyclic radicals, preferably of 3 to 8 carbons, including but not limited to, cyclopropyl, cyclopentyl, cyclohexyl, and the like. The term "cycloalkenyl" is used herein to mean cyclic radicals, preferably of 5 to 8 carbons, which have at least one bond including but not limited to cyclopentenyl, cyclohexenyl, and the like. The term "alkenyl" is used herein at all occurrences to mean straight or branched chain radical of 2-10 carbon atoms, unless the chain length is limited thereto, including, but not limited to ethenyl, 1-propenyl, 2-propenyl, 2-methyl-l- propenyl, 1-butenyl, 2-butenyl and the like. The term "aryl" is used herein to mean phenyl and naphthyl. The term "heteroaryl" (on its own or in any combination, such as "heteroaryloxy", or "heteroaryl alkyl") is used herein to mean a 5-10 membered aromatic ring system in which one or more rings contain one or more heteroatoms selected from the group consisting of N, O or S, such as, but not limited, to pyrrole, pyrazole, furan, thiophene, quinoline, isoquinoline, quinazolinyl, pyridine, pyrimidine, oxazole, thiazole, thiadiazole, tetrazole, triazole, imidazole, or benzimidazole. The term "heterocyclic" (on its own or in any combination, such as "heterocyclylalkyl") is used herein to mean a saturated or partially unsaturated 4-10 membered ring system in which one or more rings contain one or more heteroatoms selected from the group consisting of N, O, or S; such as, but not limited to, pyrrolidine, piperidine, piperazine, morpholine, tetrahydropyran, or imidazolidine. The term "aralkyl" or "heteroarylalkyl" or "heterocyclicalkyl" or "cycloalkyl alkyl" or cycloalkenylalkyl" is used herein to mean a Cl-4 alkyl chain, as defined above, which chain is attached to the respective aryl, heteroaryl, heterocyclic, cycloalkyl or cycloalkenyl moiety as also defined herein unless otherwise indicated. The term "sulfinyl" is used herein to mean the oxide S(O) of the corresponding sulfide; the term "thio" refers to the sulfide; and the term "sulfonyl" refers to the fully oxidized S(O)2 moiety. The term "aroyl" is used herein to mean C(O)Ar, wherein Ar is as phenyl, naphthyl, or an arylalkyl derivative such as defined above, such group include but are not limited to benzyl and phenethyl. The term "alkanoyl" is used herein to mean C(O)Ci_io alkyl, wherein the alkyl chain is as defined above. It is recognized that the compounds of the present invention may exist as stereoisomers, regioisomers, or diastereiomers. These compounds may contain one or more asymmetric carbon atoms and may exist in racemic and optically active forms. All of these compounds are included within the scope of the present invention. Exemplified compounds of the compounds of Formulas (I) to (IN) and (la) to (INa) include those described in the synthetic examples, and those noted below, and their pharmaceutically acceptable salt thereof. Exemplified compounds of Formula (I), include: 7-Methylsulfanyl-5-phenyl-l-(l-phenylethyl)-3,4-dihydro-lH-pyrimido[4,5-cfI pyrimidin-2-one Exemplified compounds of Formula (la), include: 7-Methylsulfanyl-5-phenyl-l-(l-phenylethyl)-lH-pyrimido[4,5--i]pyriπιidin-2-one Exemplified compounds of Formula (II), include: 5-Benzyl-7-(3-morpholin-4-yl-propylamino)-l-phenyl-3,4-dihydro-lΗ- pyrimido[4,5- ]pyrimidin-2-one Exemplified compounds of Formula (Ila), include: 5-Benzyl-7-(3-morpholin-4-yl-propylamino)-l-phenyl-lH-pyrimido[4,5- J]pyrimidin-2-one Exemplified compounds of Formula (III), include: 7-(4-Methyl-piperazin- 1 -yl)- 1 ,5-diphenyl-3 ,4-dihydro- lH-pyrimido [4,5-J] pyrimidin-2-one Exemplified compounds of Formula (Ilia), include: 7-(4-Methyl-piperazin-l-yl)-l,5-diphenyl-lH-pyrimido[4,5--i] pyrimidin-2-one Exemplified compounds of Formula (IN), include, but are not limited to, 1 -(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-methylsulfanyl-3 ,4-dihydro- lΗ-pyrimido[4,5-d]pyrimidin-2-one; Exemplified compounds of Formula (INa), include: 7-Methylsulfanyl- 1 ,5-diphenyl- lH-pyrirmdo[4,5--i]pyrimidin-2-one. The compounds of Formula (I), (II), (III), (IN) and (N) may be obtained by applying synthetic procedures, described herein. The synthesis provided for is applicable to producing compounds of Formula (I) to (N) having a variety of different Ri, R2, Y, X, and R3 groups which are reacted, employing optional substituents which are suitably protected, to achieve compatibility with the reactions outlined herein. Subsequent deprotection, in those cases, then affords compounds of the nature generally disclosed. Once the nucleus has been established, further compounds of Formula (I) may be prepared by applying standard techniques for functional group interconversion, well known in the art. For instance: C(O)NR4Ri4 from CO2CH3 by heating with or without catalytic metal cyanide, e.g. NaCN, and HNR4R14 in CH3OH; OC(O)R3 from OH with e.g., ClC(O)R3 in pyridine; NRio-C(S)NR4Ri4 from NHRio with an alkylisothiocyante or thiocyanic acid; NRιoC(O)OR7 from NHRio with the alkyl chloroformate; NRιoC(O)NR4Ri4 from NHRio by treatment with an isocyanate, e.g. HN=C=O or RioN=C=O; NRιo-C(O)R7 from NHRio by treatment with Cl-C(O)R7 in pyridine; C(=NRio)NR4Ri4 from C(NR4Ri4)SR3 with H3NR3+OAC- by heating in alcohol; C(NR4Ri4)SR3 from C(S)NR4Ri4 with R6-I in an inert solvent, e.g. acetone; C(S)NR4Ri4 (where R4 or R14 is not hydrogen) from C(S)NH2 with HNR4Ri4-C(=NCN)-NR4Ri4 from C(=NR4Ri4)- SR3 with NH2CN by heating in anhydrous alcohol, alternatively from C(=NH)- NR4R14 by treatment with BrCN and NaOEt in EtOH; NR10SO2R3 from NHRio by treatment with CISO2R3 by heating in pyridine; NRιoC(S)R6 from NRioC(O)R6 by treatment with Lawesson's reagent [2,4-bw(4-methoxyphenyl)- l,3,2,4-dithiadiphosphetane-2,4-disulfide]; NR10SO2CF3 from NHR6 with triflic anhydride and base wherein R3, R6, R7, RlO. R4 an d Rl4 are as defined in Formula (IN) herein. Further, other precursors of the various substituent groups herein may be other groups of compounds of Formula (I) to (N) which may be interconverted by applying standard techniques for this functional group interconversion. Such as use of the S-alkyl intermediate for X in compounds of Formula (IN) which are oxidized and displaced by a suitable nucleophile to yield other final products of Formula (IN). Also for example, wherein a moiety is a halo substituted CI_IQ alkyl it can be converted to the corresponding CI_IQ alkylΝ3 derivative by reacting with a suitable azide salt, and thereafter if desired can be reduced to the corresponding Cι_iQalkylNH2 compound, which in turn can be reacted with R7S(0)2X wherein X is halo (e.g., chloro) to yield the corresponding Cι_ιoalkylNHS(0)2R7 compound. Alternatively wherein the moiety is a halo-substituted Cι_iQ-alkyl it can be reacted with an amine R4R14NH to yield the corresponding Cι_ιo- lkylNR4Ri4 compound, or can be reacted with an alkali metal salt of R7SH to yield the corresponding Cι_ιoalkylSR7 compound. Suitable protecting groups for use with hydroxyl groups and nitrogen groups are well known in the art and described in many references, for instance, Protecting Groups in Organic Synthesis, Greene T W, Wiley-Interscience, New York, 1981. Suitable examples of hydroxyl protecting groups include silyl ethers, such as t- butyldimethyl or t-butyldiphenyl, and alkyl ethers, such as methyl connected by an alkyl chain of variable link, (CR oR2θ)n- Pharmaceutically acid addition salts of compounds of Formula (I) to (N), and (la) to (Na) may be obtained in known manner, for example by treatment thereof with an appropriate amount of acid in the presence of a suitable solvent. Scheme 1 HCI Ni In Schemes I and π herein, Xι is a C ι_ιo alkyl, aryl, or heteroaryl group, and Y-Ri is as defined for Formula (IN) compounds. Commercially available 4,6-dihydroxy-2-methylmercaptopyrimidine (1) (which can also be prepared by the literature methods and utilized as described below, with S-alkyl other than S-methyl or S-aryl) was converted to the nitrile (3) by the literature procedure [see Santilli, et al., I. Heterocycl. Chem. 1971, 8, 445-453] (Scheme 1). Compound 3 reacts with one equivalent of amine by procedures analogous to those described for related compounds, to afford the 2- methylsulfanyl-4-cMoro-6-amino-pyrimidine-5-carbonitrile (4) [See Tumkevicius, S. Liebigs Ann. 1995, 1703-1705]. The Suzuki reaction of 4 with aryl boronic acids using a palladium catalyst, such as, tetra/c -f(triphenylphophine) palladium(O) catalyst proceeds in good to excellent yield. Alternatively, the bi-aryl coupling reaction of (4) can be performed using aryl or heteroaryl organozinc, organcopper, organotin, or other organometallic reagents known to afford bi-aryl cross-coupling products [See for example Solberg, J.; Undheim, K. Acta Chemica Scandinavia 1989, 62-68]. Displacement of the chlorine in 4 may also be achieved with nitrogen nucleophiles [For related aminations see US patent 3,631,045 and 3,910,913]. Displacment of the chlorine in 4 is also possible with S nucleophiles, [See Tumkevicius, S. Liebigs Ann. 1995, 1703-1705] or O, or alkyl nucleophiles. The 7-methylsufamyl-l,5-disubstituted-3,4-dihydro-lH-pyrimido[4,5- d]pyrimidin-2-ones (7) are prepared by reduction of the nitriles (5) preferably with a hydride reducing agent, such as lithium aluminum hydride or NaB 2 H 7 preferably in an ethereal solvent, such as THF, Et 2 O, glyme or dioxane to produce the di-amine (6). In cases where functionality is incompatible with the more reactive hydride reducing agents, alternative, selective, reduction methods for the nitriles include samarium di-iodide in H 3 PO 4 , Raney Ni catalyzed hydrogenation, or sodium borohydride-cobaltous chloride. The resulting diamines 6 can be cyclized to (7) with carbonyldiimidazole or a mixed anhydride such as ethyl chloroformate, or for less reactive diamines, with phosgene or triphosgene and a suitable tertiary amine base at temperatures between -78° and 100°C. Oxidation of the sulfides (7) with an oxidant such as one or two equivalents of et -chloroperoxybenzoic acid or Oxone ® affords either the sulfoxides or sulfones. Oxidation of the sulfides to sulfones can also be effected by OsO 4 and catalytic tertiary amine N-oxide. Other methods for sulfide oxidation include the use of hydrogen peroxide, other peracids, oxygen, ozone, organic peroxides, potassium and zinc permanganate, potassium persulfate, and sodium hypochlorite. Both 2-pyrimidininyl sulfones and sulfoxides related to compounds of Formula (IN) wherein X is SO-alkyl or SO 2 -alkyl have been reported in the literature to be displaced by a wide variety of nucleophiles. Thus the analogs of Formula (IN) compounds wherein X is an alkyl sulfone or sulfoxide may be displaced by primary and secondary alkylamines without additional base catalysis, preferably in a polar aprotic solvent, such as but not limited to, Ν-methyl pyrrolidin-2-one (ΝMP), and at varying temperatures depending upon the nucleophilicity of the amine. For instance displacement of the sulfone of analogs of Formula (IN) compounds with ethanolamine, in ΝMP, occurs in 30 min. at about 65° while a more hindered amine such as Tris(hydroxymethyl)aminomethane requires elevated temperatures and extended reaction times (such as, about 80° and about a 24 hour reaction time). The sulfone may also be displaced with substituted arylamine, or heteroarylamines at elevated temperatures, sometimes requiring formation of the aryl or heteroarylamine anion as with sodium hydride, or other suitable base, in DMSO. In addition, the sulfoxide analogs of Formula (IN) compounds may be readily displaced with aluminum salts of aryl or heteroaryl amines as previously described in the patent literature (WO 9932121). Likewise, sulfone and sulfoxide analogs of (IN) may be displaced with aryl or heteroaryl or alkyl thiols or alkyl or aryl or heteroaryl alcohols. For instance analogs of IN containing sulfones as the X substituents may be displaced with sodium alkoxide in the alcohol or alternatively reactive alkoxide or phenoxide nucleophiles may be generated from the alcohol or phenol with a suitable base such as ΝaH or sodium bis-trimethylsilyl amide in a polar aprotic solvent such as DMSO. Similarly 2-pyrimidinyl sulfones related to (IN) may be displaced with carbon nucleophiles such as aryl or alkyl Grignard reagents or related organometalics such as organo lithium, zinc, tin or boron. These reactions may, in some cases, require transition metal catalysis such as with Pd or Νi catalysts. Displacement of related 2-pyrimidine sulfones with cyanide, malonate anions, unactivated enolates, or heterocyclic C nucleophiles such as 1-methylimidazole anion, by the generation of the anion with ΝaH or other suitable base in THF also has precedent (see for example, Chem Pharm Bull. 1987, 4972-4976.). For example analogs of (IN) compounds wherein X is an alkyl sulfone may be displaced with the anion of 1 -methyl imidazole, generated by treatment of 1 -methyl imidazole with n- butyl lithium in a solvent such as THF at temperatures of about -70°, to afford the C- alkylated product substituted on the imidazole C-2. The 3,4-Dihydro-lH-pyrimido[4,5-d]pyrimidin-2-ones, unsubstituted at the 7 position (9) (Scheme 1) can be obtained by Raney Νi hydrogenolysis of the SMe compound (7) as well as by direct synthesis from the analog of 1 (in Scheme 1) which lacks the S alkyl substituent. The oxidized series of analogs of Formula (IVa) compounds may be prepared from 5 by partial reduction of the nitrile with a suitable hydride reducing agent such as diisobutylaluminum hydride, preferably at low temperature, and avoiding hydrolytic conditions, to afford the irnine (Scheme 2). Cyclization of the imine with phosgene or a less reactive equivalent of phosgene such as carbonyldiimidazole affords la (Scheme 2). - Scheme 2 Substitution at the 7 position of the 3,4-dihydro-lH-pyrimido[4,5- d]pyrimidin-2-ones with aryl substituents is also readily achieved by preforming the 2-aryl pyrimidines as depicted in Scheme 3 below. While the scheme displays Ri and X as an aryl moiety, it is merely for respresentation purposes herein. Scheme 3. Another aspect of the present invention are the intermediate compounds of Formula (A): wherein Y-Ri and R3 are as defined herein for Formula (IN); and Xi is a C _ιo alkyl, aryl or heteroaryl moiety. Preferably Xι is a Cl-10 alkyl, more preferably a methyl or propyl. Another aspect of the present invention are the intermediate compounds of Formula (C): wherein Y-Ri and R3 are as defined herein for Formula (IN); and Xi is a C I_IQ alkyl, aryl or heteroaryl moiety. Preferably Xi is a Cl-10 alkyl, more preferably a methyl or propyl. METHODS OF TREATMENT The compounds of Formula (I) to (V) and (la) to (Na) or a pharmaceutically acceptable salt thereof can be used in the manufacture of a medicament for the prophylactic or therapeutic treatment of any disease state in a human, or other mammal, which is exacerbated or caused by excessive or unregulated cytokine production by such mammal's cell, such as but not limited to monocytes and/or macrophages; or by the exacerbation or excessive or unregulated production of the CSBP protein. For purposes herein, compounds of Formula (I) to (N) and (la) to (Na) will all be referred to as compounds of Formula (I) unless otherwise indicated. Compounds of Formula (I) are capable of inhibiting proinflammatory cytokines, such as IL-1, IL-6, IL-8, and TΝF and are therefore of use in therapy. IL-1, IL-6, IL-8 and TΝF affect a wide variety of cells and tissues and these cytokines, as well as other leukocyte-derived cytokines, are important and critical inflammatory mediators of a wide variety of disease states and conditions. The inhibition of these pro-inflammatory cytokines is of benefit in controlling, reducing and alleviating many of these disease states. Accordingly, the present invention provides a method of treating a cytokine- mediated disease which comprises administering an effective cytokine-interfering amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Compounds of Formula (I) are capable of inhibiting inducible proinflammatory proteins, such as COX-2, also referred to by many other names such as prostaglandin endoperoxide synthase-2 (PGHS-2) and are therefore of use in therapy. These proinflammatory lipid mediators of the cyclooxygenase (CO) pathway are produced by the inducible COX-2 enzyme. Regulation, therefore of COX-2 which is responsible for the these products derived from arachidonic acid, such as prostaglandins affect a wide variety of cells and tissues are important and critical inflammatory mediators of a wide variety of disease states and conditions. Expression of COX-1 is not effected by compounds of Formula (I). This selective inhibition of COX-2 may alleviate or spare ulcerogenic liability associated with inhibition of COX-1 thereby inhibiting prostoglandins essential for cytoprotective effects. Thus inhibition of these pro-inflammatory mediators is of benefit in controlling, reducing and alleviating many of these disease states. Most notably these inflammatory mediators, in particular prostaglandins, have been implicated in pain, such as in the sensitization of pain receptors, or edema. This aspect of pain management therefore includes treatment of neuromuscular pain, headache, cancer pain, and arthritis pain. Compounds of Formula (I) or a pharmaceutically acceptable salt thereof, are of use in the prophylaxis or therapy in a human, or other mammal, by inhibition of the synthesis of the COX-2 enzyme. Accordingly, the present invention provides a method of inhibiting the synthesis of COX-2 which comprises administering an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. The present invention also provides for a method of prophylaxis treatment in a human, or other mammal, by inhibition of the synthesis of the COX-2 enzyme. In particular, compounds of Formula (I) or a pharmaceutically acceptable salt thereof are of use in the prophylaxis or therapy of any disease state in a human, or other mammal, which is exacerbated by or caused by excessive or unregulated IL-1, IL-6, IL-8 or TNF production by such mammal 's cell, such as, but not limited to, monocytes and/or macrophages. Accordingly, in another aspect, this invention relates to a method of inhibiting the production of D -l in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. There are many disease states in which excessive or unregulated IL-1 production is implicated in exacerbating and/or causing the disease. These include rheumatoid arthritis, osteoarthritis, meningitis, ischemic and hemorrhagic stroke, neurotrauma/closed head injury, stroke, endotoxemia and/or toxic shock syndrome, other acute or chronic inflammatory disease states such as the inflammatory reaction induced by endotoxin or inflammatory bowel disease, tuberculosis, atherosclerosis, muscle degeneration, multiple sclerosis, cachexia, bone resorption, psoriatic arthritis, Reiter's syndrome, rheumatoid arthritis, gout, traumatic arthritis, rubella arthritis and acute synovitis. Recent evidence also links IL-1 activity to diabetes, pancreatic β cell diseases and Alzheimer's disease. Use of a CS AID for the treatment of CSBP mediated disease states, can include, but not be limited to neurodegenerative diseases, such as Alzheimer's disease (as noted above), Parkinson's disease and multiple sclerosis, etc. In a further aspect, this invention relates to a method of inhibiting the production of TNF in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Excessive or unregulated TNF production has been implicated in mediating or exacerbating a number of diseases including rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions, sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, adult respiratory distress syndrome, chronic pulmonary inflammatory disease and chronic obstructive pulmonary disease, silicosis, pulmonary sarcoisosis, bone resorption diseases, such as osteoporosis, cardiac, brain and renal reperfusion injury, graft vs. host reaction, allograft rejections, fever and myalgias due to infection, such as influenza, brain infections including encephalitis (including HIN-induced forms), cerebral malaria, meningitis, ischemic and hemorrhagic stroke, cachexia secondary to infection or malignancy, cachexia secondary to acquired immune deficiency syndrome (AIDS), AIDS, ARC (AIDS related complex), keloid formation, scar tissue formation, inflammatory bowel disease, Crohn's disease, ulcerative colitis and pyresis. Compounds of Formula (I) are also useful in the treatment of viral infections, where such viruses are sensitive to upregulation by TNF or will elicit TNF production in vivo. The viruses contemplated for treatment herein are those that produce TNF as a result of infection, or those which are sensitive to inhibition, such as by decreased replication, directly or indirectly, by the TNF inhibiting-compounds of Formula (1). Such viruses include, but are not limited to HIV- 1, HIV-2 and HIV-3, Cytomegalovirus (CMV), Influenza, adeno virus and the Herpes group of viruses, such as but not limited to, Herpes Zoster and Herpes Simplex. Accordingly, in a further aspect, this invention relates to a method of treating a mammal afflicted with a human immunodeficiency virus (H-tN) which comprises administering to such mammal an effective TNF inhibiting amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. It is also recognized that both IL-6 and IL-8 are produced during rhinovirus (HRV) infections and contribute to the pathogenesis of common cold and exacerbation of asthma associated with HRV infection (Turner et al., (1998), Clin. Infec. Dis., Vol 26, p 840; Teren et al, (1997), Am J Respir Crit Care Med vol 155, pl362; Grunberg et al. (1997), Am J Respir Crit Care Med 156:609 and Zhu et al, J Clin Invest (1996), 97:421). It has also been demonstrated in vitro that infection of pulmonary epithelial cells with HRV results in production of IL-6 and IL-8 (Subauste et al, J. Clin. Invest. 1995, 96:549.) Epithelial cells represent the primary site of infection of HRV. Therefore another aspect of the present invention is a method of treatment to reduce inflammation associated with a rhinovirus infection, not necessarily a direct effect on virus itself. Compounds of Formula (I) may also be used in association with the veterinary treatment of mammals, other than in humans, in need of inhibition of TNF production. TNF mediated diseases for treatment, therapeutically or prophylactically, in animals include disease states such as those noted above, but in particular viral infections. Examples of such viruses include, but are not limited to, lentivirus infections such as, equine infectious anaemia virus, caprine arthritis virus, visna virus, or maedi virus or retrovirus infections, such as but not limited to feline immunodeficiency virus (FIN), bovine immunodeficiency virus, or canine immunodeficiency virus or other retro viral infections. The compounds of Formula (I) may also be used topically in the treatment or prophylaxis of topical disease states mediated by or exacerbated by excessive cytokine production, such as by E -1 or TΝF respectively, such as inflamed joints, eczema, psoriasis and other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation. Periodontal disease has also been implemented in cytokine production, both topically and systemically. Hence use of compounds of Formula (I) to control the inflammation associated with cytokine production in such peroral diseases such as gingivitis and periodontitis is another aspect of the present invention. Compounds of Formula (I) have also been shown to inhibit the production of IL-8 (Interleukin-8, NAP). Accordingly, in a further aspect, this invention relates to a method of inhibiting the production of IL-8 in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. There are many disease states in which excessive or unregulated IL-8 production is implicated in exacerbating and/or causing the disease. These diseases are characterized by massive neutrophil infiltration such as, psoriasis, inflammatory bowel disease, asthma, cardiac, brain and renal repeRtusion injury, adult respiratory distress syndrome, thrombosis and glomerulonephritis. All of these diseases are associated with increased IL-8 production which is responsible for the chemotaxis of neutrophils into the inflammatory site. In contrast to other inflammatory cytokines (IL-1, TNF, and IL-6), IL-8 has the unique property of promoting neutrophil chemotaxis and activation. Therefore, the inhibition of IL-8 production would lead to a direct reduction in the neutrophil infiltration. The compounds of Formula (I) are administered in an amount sufficient to inhibit cytokine, in particular IL-1, IL-6, IL-8 or TNF, production such that it is regulated down to normal levels, or in some case to subnormal levels, so as to ameliorate or prevent the disease state. Abnormal levels of IL-1, IL-6, IL-8 or TNF, for instance in the context of the present invention, constitute: (i) levels of free (not cell bound) IL-1, IL-6, IL-8 or TNF greater than or equal to 1 picogram per ml; (ii) any cell associated IL-1, IL-6, IL-8 or TNF; or (iii) the presence of IL-1, IL-6, IL-8 or TNF mRNA above basal levels in cells or tissues in which E -1, IL-6, IL-8 or TNF, respectively, is produced. The discovery that the compounds of Formula (I) are inhibitors of cytokines, specifically IL-1, IL-6, IL-8 and TNF is based upon the effects of the compounds of Formulas (I) on the production of the IL-1, IL-8 and TNF in in vitro assays which are described herein. As used herein, the term "inhibiting the production of IL-1 (IL-6, IL-8 or TNF)" refers to: a) a decrease of excessive in vivo levels of the cytokine (IL-1, IL-6, IL-8 or TNF) in a human to normal or sub-normal levels by inhibition of the in release of the cytokine by all cells, including but not limited to monocytes or macrophages; b) a down regulation, at the genomic level, of excessive in vivo levels of the cytokine (IL-1, IL-6, IL-8 or TNF) in a human to normal or sub-normal levels; c) a down regulation, by inhibition of the direct synthesis of the cytokine (IL- 1, IL-6, IL-8 or TNF) as a postranslational event; or d) a down regulation, at the translational level, of excessive in vivo levels of the cytokine (IL-1, IL-6, IL-8 or TNF) in a human to normal or sub-normal levels. As used herein, the term "TNF mediated disease or disease state" refers to any and all disease states in which TNF plays a role, either by production of TNF itself, or by TNF causing another monokine to be released, such as but not limited to IL-1, IL-6 or IL-8. A disease state in which, for instance, IL-1 is a major component, and whose production or action, is exacerbated or secreted in response to TNF, would therefore be considered a disease stated mediated by TNF. As used herein, the term "cytokine" refers to any secreted polypeptide that affects the functions of cells and is a molecule which modulates interactions between cells in the immune, inflammatory or hematopoietic response. A cytokine includes, but is not limited to, monokines and lymphokines, regardless of which cells produce them. For instance, a monokine is generally referred to as being produced and secreted by a mononuclear cell, such as a macrophage and/or monocyte. Many other cells however also produce monokines, such as natural killer cells, fibroblasts, basophils, neutrophils, endothelial cells, brain astrocytes, bone marrow stromal cells, epideral keratinocytes and B -lymphocytes. Lymphokines are generally referred to as being produced by lymphocyte cells. Examples of cytokines include, but are not limited to, Interleukin-1 (D -1), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Tumor Necrosis Factor-alpha (TNF-a) and Tumor Necrosis Factor beta (TNF-β). As used herein, the term "cytokine interfering" or "cytokine suppressive amount" refers to an effective amount of a compound of Formula (I) which will cause a decrease in the in vivo levels of the cytokine to normal or sub-normal levels, when given to a patient for the prophylaxis or treatment of a disease state which is exacerbated by, or caused by, excessive or unregulated cytokine production. As used herein, the cytokine referred to in the phrase "inhibition of a cytokine, for use in the treatment of a HIN-infected human" is a cytokine which is implicated in (a) the initiation and/or maintenance of T cell activation and/or activated T cell- mediated HIV gene expression and/or replication and/or (b) any cytokine-mediated disease associated problem such as cachexia or muscle degeneration. As TNF-β (also known as lymphotoxin) has close structural homology with TNF-α (also known as cachectin) and since each induces similar biologic responses and binds to the same cellular receptor, both TNF-α and TNF-β are inhibited by the compounds of the present invention and thus are herein referred to collectively as "TNF" unless specifically delineated otherwise. A member of the MAP kinase family, alternatively termed CSBP, p38, or RK, has been identified independently by several laboratories. Activation of this novel protein kinase via dual phosphorylation has been observed in different cell systems upon stimulation by a wide spectrum of stimuli, such as physicochemical stress and treatment with lipopolysaccharide or proinflammatory cytokines such as interleukin-1 and tumor necrosis factor. The cytokine biosynthesis inhibitors, of the present invention, compounds of Formula (I) have been determined to be potent and selective inhibitors of CSBP/p38/RK kinase activity. These inhibitors are of aid in determining the signaling pathways involvement in inflammatory responses. In particular, for the first time a definitive signal transduction pathway can be prescribed to the action of lipopolysaccharide in cytokine production in macrophages. In addition to those diseases already noted, treatment of stroke, neurotrauma, cardiac and renal reperfusion injury, congestive heart failure, coronary arterial bypass grafting (CABG) surgery, chronic renal failure, angiogenesis & related processes, such as cancer, thrombosis, glomerulonephritis, diabetes and pancreatic β cells, multiple sclerosis, muscle degeneration, eczema, psoriasis, sunburn, and conjunctivitis are also included. The CSBP inhibitors were subsequently tested in a number of animal models for anti-inflammatory activity. Model systems were chosen that were relatively insensitive to cyclooxygenase inhibitors in order to reveal the unique activities of cytokine suppressive agents. The inhibitors exhibited significant activity in many such in vivo studies. Most notable are its effectiveness in the collagen-induced arthritis model and inhibition of TNF production in the endotoxic shock model. In the latter study, the reduction in plasma level of TNF correlated with survival and protection from endotoxic shock related mortality. Also of great importance are the compounds effectiveness in inhibiting bone resorption in a rat fetal long bone organ culture system. Griswold et al., (1988) Arthritis Rheum. 31:1406-1412; Badger, et al., (1989) Circ. Shock 27, 51-61; Votta et al., (1994)in vitro. Bone 15, 533-538; Lee et al., (1993). B Ann. N. Y. Acad. Sci. 696, 149-170. Chronic diseases which have an inappropriate angiogenic component are various ocular neovasularizations, such as diabetic retinopathy and macular degeneration. Other chronic diseases which have an excessive or increased proliferation of vasculature are tumor growth and metastasis, atherosclerosis, and certain arthritic conditions. Therefore CSBP kinase inhibitors will be of utility in the blocking of the angiogenic component of these disease states. The term "excessive or increased proliferation of vasculature inappropriate angiogenesis" as used herein includes, but is not limited to, diseases which are characterized by hemangiomas and ocular diseases. The term "inappropriate angiogenesis" as used herein includes, but is not limited to, diseases which are characterized by vesicle proliferation with accompanying tissue proliferation, such as occurs in cancer, metastasis, arthritis and atherosclerosis. Another aspect of the present invention is a method of treating the common cold or respiratory viral infection caused by human rhinovirus (HRN), other entero viruses, coronavirus, influenza virus, parainfluenza virus, respiratory syncytial virus, or adeno virus in a human in need thereof which method comprises administering to said human an effective amount of a CBSP/p38 inhibitor. Another aspect of the present invention is a method of treating, including prophylaxis of influenza induced pneumonia in a human in need thereof which method comprises administering to said human an effective amount of a CBSP/p38 inhibitor The present invention also relates to the use of the CSBP/p38 kinase inhibitor for the treatment, including prophylaxis, of inflammation associated with a viral infection of a human rhinovirus (HRN), other enteroviruses, coronavirus, influenza virus, parainfluenza virus, respiratory syncytial virus, or adenovirus. In particular, the present invention is directed to the treatment of a viral infection in a human, which is caused by the human rhinovirus (HRN), other enterovirus, coronavirus, influenza virus, parainfluenza virus, respiratory syncytial virus, or an adenovirus. In particular the invention is directed to respiratory viral infections that exacerbate asthma (induced by such infections), chronic bronchitis, chronic obstructive pulmonary disease, otitis media, and sinusitis. While inhibiting IL-8 or other cytokines may be beneficial in treating a rhinovirus may be known, the use of an inhibitor of the p38 kinase for treating HRN or other respiratory viral infections causing the common cold is believed novel. It should be noted that the respiratory viral infection treated herein may also be associated with a secondary bacterial infection, such as otitis media, sinusitis, or pneumonia. For use herein treatment may include prophylaxis for use in a treatment group susceptible to such infections. It may also include reducing the symptoms of, ameliorating the symptoms of, reducing the severity of, reducing the incidence of, or any other change in the condition of the patient, which improves the therapeutic outcome. It should be noted that the treatment herein is not directed to the elimination or treatment of the viral organism itself but is directed to treatment of the respiratory viral infection that exacerbates other diseases or symptoms of disease, such as asthma (induced by such infections), chronic bronchitis, chronic obstructive pulmonary disease, otitis media, and sinusitis. A preferred virus for treatment herein is the human rhinovirus infection (HRN) or respiratory syncytial virus (RSN). Another aspect of the present invention is directed to the treatment of inhaled smoke induced airway inflammation, lung chemokine production and cytokine production. The invention may be directed to treatment of the airway induced inflammation which is secondary to other respiratory disorders such as viral infections that exacerbate asthma (induced by such infections), chronic bronchitis, chronic obstructive pulmonary disease, otitis media, and sinusitis. A respiratory viral infection treated in conjunction with the smoke related airway inflammation may also be associated with a secondary bacterial infection, such as otitis media, sinusitis, or pneumonia. It is noted that the inflammation may be due to cytokines and chemokine release from neutrophile activation and other leukocytes, as well as vascular and airway endothelial cell activiation. For use herein treatment may include prophylaxis for use in a treatment group who may be susceptible to such airway inflammation. It may also include reducing the symptoms of, ameliorating the symptoms of, reducing the severity of, reducing the incidence of, or any other change in the condition of the patient, which improves the therapeutic outcome. Suitable patient populations for whom this may be prophylatically beneficial could be firemen who routinely inhale smoke in the course of their duties; use in the military, and by civilians in wartime exposure. As noted, smoke of natural causes, such as plant extracts, natural plants products, synthetic material, chemically treated natural materials, or natural products such as oil and gas or other fossil fuels, may be treated within the scope of this invention. Suitably, the treatment including prophylaxis is related to cigarette smoke or synthetic/composites, such as occur in fires associated with buring buildings or homes. Another aspect of the present invention relates to the use of a CSBP/p38 kinase inhibitor for the treatment, including prophylaxis, of the hypertussive activity associated withwith resulting airway inflammation and/or cough in a mammal in need thereof. The present invention also relates to use of a CSBP/p38 kinase inhibitor for the treatment, including prophylaxis, of the inflammation enhanced cought related disorders in a mammal in need thereof. The present invention is also directed to the use of a compound of Formula (I) in eosinophilic bronchitis, and in cough variant asthma. The compounds of Formula (I) may also be used in the treatment, including prophylaxis, of eosinophilic inflammation in the airways and cough. Treatment, including prophylaxis is appropriate for eosinophilic bronchitis (as this differs from asthma) and for the treatment, including prophylaxis of cough variant asthma. These disorders may be directed to treatment of the airway induced inflammation which is secondary to other respiratory disorders such as viral infections that exacerbate asthma (induced by such infections), chronic bronchitis, chronic obstructive pulmonary disease, otitis media, and sinusitis. A respiratory viral infection treated in conjunction with the smoke related airway inflammation may also be associated with a secondary bacterial infection, such as otitis media, sinusitis, or pneumonia. The hypertussive or inflammation enhanced cough related disorders may either be a direct result of or an association with eosinophilia activity. It may also be a result of, or associated with the blocking production of certain cytokines which may mediate these phenomena. For use herein treatment may include prophylaxis for use in a treatment group who may be susceptible to such airway inflammation, and/or cough. It may also include reducing the symptoms of, ameliorating the symptoms of, reducing the severity of, reducing the incidence of, or any other change in the condition of the patient, which improves the therapeutic outcome. Clinically, eosinophilic bronchitis presents as chronic cough and sputum eosinophilia, but without the abnormalities of airway function seen in asthma. In contrast to cough in patients without sputum eosinophilia, the cough responds to anti-inflammatory therapy, such as inhaled corticosteroids (Niimi et al., Eosinophilic inflammation in cough variant asthma, European Respiratory Journal. 11(5): 1064-9, (1998)). Patients with cough-variant asthma may also have the following criteria: (1) have not been previously diagnosed as having asthma; (2) complain of a cough of at least a 3-week duration; (3) do not complain of wheezing, shortness of breath, or chest tightness; (4) have normal results of physical examinations; (5) have normal or nearly normal results of spirometry; (6) have evidence of bronchial hyperresponsiveness during bronchoprovocation challenge testing; and (7) have a favorable response to asthma medications (Irwin et al., Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma (Archives of Internal Medicine. 157(17):1981-1987, (1997)). Unlike conventional anti-tussive agents, such as codeine or dextromethorphan, a p38 kinase inhibitor appears to have no direct antitussive activity, but reduces the airway eosmophilia and normalizes the hypertussive state. Therefore, use of a p38 inhibitor will reduce the added coughs, or hypertussive state, back to a normal level which can be suitably treated with conventional agents and/or therapies as appropriate. Use of the p38 inhibitors will allow for the maintenance of patients who are subject to increased cough responsiveness, especially unproductive cough, due to other underlying disorders or treatments. This increased cough responsiveness may be modulated, or decreased by use of this innovative anti-inflammatory therapy. Accordingly, the present invention provides a method of treating a CSBP kinase mediated disease in a mammal in need thereof, preferably a human, which comprises administering to said mammal, an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. In order to use a compound of Formula (I) or a pharmaceutically acceptable salt thereof in therapy, it will normally be formulated into a pharmaceutical composition in accordance with standard pharmaceutical practice. This invention, therefore, also relates to a pharmaceutical composition comprising an effective, non- toxic amount of a compound of Formula (I) and a pharmaceutically acceptable carrier or diluent. Compounds of Formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions incorporating such may conveniently be administered by any of the routes conventionally used for drug administration, for instance, orally, topically, parenterally or by inhalation. The compounds of Formula (I) may be ά administered in conventional dosage forms prepared by combining a compound of Formula (I) with standard pharmaceutical carriers according to conventional procedures. The compounds of Formula (I) may also be administered in conventional dosages in combination with a known, second therapeutically active compound. These procedures may involve mixing, granulating and compressing or dissolving the ingredients as appropriate to the desired preparation. It will be appreciated that the form and character of the pharmaceutically acceptable character or diluent is dictated by the amount of active ingredient with which it is to be combined, the route of administration and other well-known variables. The carrier(s) must be "acceptable" in the sense of being compatible with the other ingredients of the formulation and not deleterious to the recipient thereof. The pharmaceutical carrier employed may be, for example, either a solid or liquid. Exemplary of solid carriers are lactose, terra alba, sucrose, talc, gelatin, agar, pectin, acacia, magnesium stearate, stearic acid and the like. Exemplary of liquid carriers are syrup, peanut oil, olive oil, H2O and the like. Similarly, the carrier or diluent may include time delay material well known to the art, such as glyceryl mono-stearate or glyceryl distearate alone or with a wax. A wide variety of pharmaceutical forms can be employed. Thus, if a solid carrier is used, the preparation can be tableted, placed in a hard gelatin capsule in powder or pellet form or in the form of a troche or lozenge. The amount of solid carrier will vary widely but preferably will be from about 25mg. to about lg. When a liquid carrier is used, the preparation will be in the form of a syrup, emulsion, soft gelatin capsule, sterile injectable liquid such as an ampule or nonaqueous liquid suspension. Compounds of Formula (I) may be administered topically, that is by non- systemic administration. This includes the application of a compound of Formula (I) externally to the epidermis or the buccal cavity and the instillation of such a compound into the ear, eye and nose, such that the compound does not significantly enter the blood stream. In contrast, systemic administration refers to oral, intravenous, intraperitoneal and intramuscular administration. Formulations suitable for topical administration include liquid or semi-liquid preparations suitable for penetration through the skin to the site of inflammation such as liniments, lotions, creams, ointments or pastes, and drops suitable for administration to the eye, ear or nose. The active ingredient may comprise, for topical administration, from 0.001% to 10% w/w, for instance from 1% to 2% by weight of the formulation. It may however comprise as much as 10% w/w but preferably will comprise less than 5% w/w, more preferably from 0.1% to 1% w/w of the formulation. Lotions according to the present invention include those suitable for application to the skin or eye. An eye lotion may comprise a sterile aqueous solution optionally containing a bactericide and may be prepared by methods similar to those for the preparation of drops. Lotions or liniments for application to the skin may also include an agent to hasten drying and to cool the skin, such as an alcohol or acetone, and/or a moisturizer such as glycerol or an oil such as castor oil or arachis oil. Creams, ointments or pastes according to the present invention are semi-solid formulations of the active ingredient for external application. They may be made by mixing the active ingredient in finely-divided or powdered form, alone or in solution or suspension in an aqueous or non-aqueous fluid, with the aid of suitable machinery, with a greasy or non-greasy base. The base may comprise hydrocarbons such as hard, soft or liquid paraffin, glycerol, beeswax, a metallic soap; a mucilage; an oil of natural origin such as almond, com, arachis, castor or olive oil; wool fat or its derivatives or a fatty acid such as steric or oleic acid together with an alcohol such as propylene glycol or a macrogel. The formulation may incorporate any suitable surface active agent such as an anionic, cationic or non-ionic surfactant such as a sorbitan ester or a polyoxyethylene derivative thereof. Suspending agents such as natural gums, cellulose derivatives or inorganic materials such as silicaceous silicas, and other ingredients such as lanolin, may also be included. Drops according to the present invention may comprise sterile aqueous or oily solutions or suspensions and may be prepared by dissolving the active ingredient in a suitable aqueous solution of a bactericidal and/or fungicidal agent and/or any other suitable preservative, and preferably including a surface active agent. The resulting solution may then be clarified by filtration, transferred to a suitable container which is then sealed and sterilized by autoclaving or maintaining at 98-100°C. for half an hour. Alternatively, the solution may be sterilized by filtration and transferred to the container by an aseptic technique. Examples of bactericidal and fungicidal agents suitable for inclusion in the drops are phenylmercuric nitrate or acetate (0.002%), benzalkonium chloride (0.01%) and chlorhexidine acetate (0.01%). Suitable solvents for the preparation of an oily solution include glycerol, diluted alcohol and propylene glycol. Compounds of Formula (I) may be administered parenterally, that is by intravenous, intramuscular, subcutaneous intranasal, intrarectal, intravaginal or intraperitoneal administration. The subcutaneous and intramuscular forms of parenteral administration are generally preferred. Appropriate dosage forms for such administration may be prepared by conventional techniques. Compounds of Formula (I) may also be administered by inhalation, that is by intranasal and oral inhalation administration. Appropriate dosage forms for such administration, such as an aerosol formulation or a metered dose inhaler, may be prepared by conventional techniques. For all methods of use disclosed herein for the compounds of Formula (I), the daily oral dosage regimen will preferably be from about 0.1 to about 80 mg/kg of total body weight, preferably from about 0.2 to 30 mg/kg, more preferably from about 0.5 mg to 15mg. The daily parenteral dosage regimen about 0.1 to about 80 mg/kg of total body weight, preferably from about 0.2 to about 30 mg/kg, and more preferably from about 0.5 mg to 15mg/kg. The daily topical dosage regimen will preferably be from 0.1 mg to 150 mg, administered one to four, preferably two or three times daily. The daily inhalation dosage regimen will preferably be from about 0.01 mg/kg to about 1 mg/kg per day. It will also be recognized by one of skill in the art that the optimal quantity and spacing of individual dosages of a compound of Formula (I) or a pharmaceutically acceptable salt thereof will be determined by the nature and extent of the condition being treated, the form, route and site of administration, and the particular patient being treated, and that such optimums can be determined by conventional techniques. It will also be appreciated by one of skill in the art that the optimal course of treatment, i.e., the number of doses of a compound of Formula (I) or a pharmaceutically acceptable salt thereof given per day for a defined number of days, can be ascertained by those skilled in the art using conventional course of treatment determination tests. The novel compounds of Formula (I) may also be used in association with the veterinary treatment of mammals, other than humans, in need of inhibition of CSBP/p38 or cytokine inhibition or production. In particular, CSBP/p38 mediated diseases for treatment, therapeutically or prophylactically, in animals include disease states such as those noted herein in the Methods of Treatment section, but in particular viral infections. Examples of such viruses include, but are not limited to, lentivirus infections such as, equine infectious anaemia virus, caprine arthritis virus, visna virus, or maedi virus or retrovirus infections, such as but not limited to feline immunodeficiency virus (FIN), bovine immunodeficiency virus, or canine immunodeficiency virus or other retroviral infections. The invention will now be described by reference to the following biological examples which are merely illustrative and are not to be construed as a limitation of the scope of the present invention. BIOLOGICAL EXAMPLES The cytokine-inhibiting effects of compounds of the present invention may be determined by the following in vitro assays: Assays for Interleukin - 1 (IL-1), Interleukin -8 (IL-8 ), and Tumour Necrosis Factor (TNF) are well known in the art, and may be found in a number of publications, and patents. Representative suitable assays for use herein are described in Adams et al., US 5,593,992, whose disclosure is incorporated by reference in its entirety. Interleukin - 1 (IL-1) Human peripheral blood monocytes are isolated and purified from either fresh blood preparations from volunteer donors, or from blood bank buffy coats, according to the procedure of Colotta et al, J Immunol, 132, 936 (1984). These monocytes (lxlO 6 ) are plated in 24- well plates at a concentration of 1-2 million/ml per well. The cells are allowed to adhere for 2 hours, after which time non-adherent cells are removed by gentle washing. Test compounds are then added to the cells for lh before the addition of lipopolysaccharide (50 ng/ml), and the cultures are incubated at 37°C for an additional 24h. At the end of this period, culture supematants are removed and clarified of cells and all debris. Culture supematants are then immediately assayed for IL-1 biological activity, either by the method of Simon et al., J. Immunol. Methods, 84, 85, (1985) (based on ability of IL-1 to stimulate a Interleukin 2 producing cell line (EL-4) to secrete IL-2, in concert with A23187 ionophore) or the method of Lee et al, J. ImmunoTherapy, 6 (1), 1-12 (1990) (ELISA assay). In vivo TNF assay: (1) Griswold et al., Drugs Under Exp. and Clinical Res.,XfX (6), 243-248 (1993); or (2) Boehm, et al., ournal Of Medicinal Chemistry 39, 3929-3937 (1996) whose disclosures are incorporated by reference herein in their entirety. LPS-induced TNFα Production in Mice and Rats In order to evaluate in vivo inhibition of LPS-induced TNFα production in rodents, both mice and rats are injected with LPS. Mouse Method Male Balb/c mice from Charles River Laboratories are pretreated (30 min) with compound or vehicle. After the 30 min. pretreat time, the mice are given LPS (lipopolysaccharide from Esherichia coli Serotype 055-85, Sigma Chemical Co., St Louis, MO) 25 ug/mouse in 25 ul phosphate buffered saline (pH 7.0) intraperitoneally. Two hours later the mice are killed by CO2 inhalation and blood samples are collected by exsanguination into heparinized blood collection tubes and stored on ice. The blood samples are centrifuged and the plasma collected and stored at -20°C until assayed for TNFα by ELISA. Rat Method Male Lewis rats from Charles River Laboratories are pretreated at various times with compound or vehicle. After a determined pretreat time, the rats are given LPS (lipopolysaccharide from Esherichia coli Serotype 055-85, Sigma Chemical Co., St Louis, MO) 3.0 mg/kg intraperitoneally. The rats are killed by CO2 inhalation and heparinized whole blood is collected from each rat by cardiac puncture 90 min after the LPS injection. The blood samples are centrifuged and the plasma collected for analysis by ELISA for TNFα levels. ELISA Method TNFα levels were measured using a sandwich ELISA, as described in Olivera et al., Circ. Shock, 37, 301-306, (1992), whose disclosure is incorporated by reference in its entirety herein, using a hamster monoclonal antimurine TNFα (Genzyme, Boston, MA) as the capture antibody and a polyclonal rabbit antimurine TNFa (Genzyme) as the second antibody. For detection, a peroxidase-conjugated goat antirabbit antibody (Pierce, Rockford, J-L) was added, followed by a substrate for peroxidase (1 mg/ml orthophenylenediamine with 1% urea peroxide). TNFα levels in the plasma samples from each animal were calculated from a standard curve generated with recombinant murine TNFα (Genzyme). LPS-Stimulated Cytokine Production in Human Whole Blood Assay: Test compound concentrations were prepared at 10 X concentrations and LPS prepared at 1 ug/ml (final cone, of 50 ng/ml LPS) and added in 50 uL volumes to 1.5 mL eppendorf tubes. Heparinized human whole blood was obtained from healthy volunteers and was dispensed into eppendorf tubes containing compounds and LPS in 0.4 mL volumes and the tubes incubated at 37 C. Following a 4 hour incubation, the tubes were centrifuged at 5000 rpm for 5 min in a TOMY microfuge, plasma was withdrawn and frozen at -80 C. Cytokine measurement: J-L-I and/or TNF were quantified using a standardized ELISA technology. An in-house ELISA kit was used to detect human J-L-l and TNF. Concentrations of IL-1 or TNF were determined from standard curves of the appropriate cytokine and IC50 values for test compound (concentration that inhibited 50% of LPS-stimulated cytokine production) were calculated by linear regression analysis. CSBP/p38 Kinase Assay: This assay measures the CSBP/p38-catalyzed transfer of 32p from [a- 32p] ATP to threonine residue in an epidermal growth factor receptor (EGFR)-derived peptide (T669) with the following sequence: KRELVEPL7 SGEAPNQALLR (residues 661-681). (See Gallagher et al, "Regulation of Stress Induced Cytokine Production by Pyridinyl Imidazoles: Inhibition of CSBP Kinase", BioOrganic & Medicinal Chemistry, 1997, 5, 49-64). Reactions were carried in round bottom 96 well plate (from Coming) in a 30 ml volume. Reactions contained (in final concentration): 25 mM Hepes, pH 7.5; 8 mM MgCl2; 0.17 mM ATP (the Km[ATP] of P 38 (see Lee et al., Nature 300, n72 pg. 639-746 (Dec. 1994)); 2.5 uCi of [g-32P]ATP; 0.2 mM sodium orthovanadate; 1 mM DTT; 0.1% BSA; 10% glycerol; 0.67 mM T669 peptide; and 2-4 nM of yeast- expressed, activated and purified p38. Reactions were initiated by the addition of [gamma-32P]Mg/ATP, and incubated for 25 min. at 37 °C. Inhibitors (dissolved in DMSO) were incubated with the reaction mixture on ice for 30 min prior to adding the 32P-ATP. Final DMSO concentration was 0.16%. Reactions were terminated by adding 10 ul of 0.3 M phosphoric acid, and phosphorylated peptide was isolated from the reactions by capturing it on p81 phosphocellulose filters. Filters were washed with 75 mM phosphoric acids, and incorporated 32P was quantified using beta scintillation counter. Under these conditions, the specific activity of p38 was 400-450 pmol/pmol enzyme, and the activity was linear for up to 2 hours of incubation. The kinase activity values were obtained after subtracting values generated in the absence of substrate which were 10-15% of total values. Representative compounds of Formula (I), Examples 1 to 167 have demonstrated positive inhibitory activity in this assay, all having of IC50' S of < lOOuM in this binding assay. TNF-α in Traumatic Brain Injury Assay This assay provides for examination of the expression of tumor necrosis factor mRNA in specific brain regions which follow experimentally induced lateral fluid- percussion traumatic brain injury (TBI) in rats. Since TNF-α is able to induce nerve growth factor (NGF) and stimulate the release of other cytokines from activated astrocytes, this post-traumatic alteration in gene expression of TNF-α plays an important role in both the acute and regenerative response to CNS trauma. A suitable assay may be found in WO 97/35856 whose disclosure is incorporated herein by reference. CNS Injury model for IL-b mRNA This assay characterizes the regional expression of interleukin- lβ (IL-lβ) mRNA in specific brain regions following experimental lateral fluid-percussion traumatic brain injury (TBI) in rats. Results from these assays indicate that following TBI, the temporal expression of IL-lβ mRNA is regionally stimulated in specific brain regions. These regional changes in cytokines, such as IL-lβ play a role in the post- traumatic pathologic or regenerative sequelae of brain injury. A suitable assay may be found in WO 97/35856 whose disclosure is incorporated herein by reference. Angiogenesis Assay Described in WO 97/32583, whose disclosure is incorporated herein by reference, is an assay for determination of inflammatory angiogenesis which may be used to show that cytokine inhibition will stop the tissue destruction of excessive or inappropriate proliferation of blood vessels. Cigarette Smoke Exposure Model A murine model of cigarette smoke inhalation was developed to explore a relationship to leukocyte trafficking and lung chemokine and cytokine production. Balb/c mice are exposed to smoke generated from commercial unfiltered cigarettes for a specified period of time and samples are obtained at varying times during the post-exposure. This model is demonstrated in greater detail as shown below, in contrast to other smoke extract models known in the art. A model of cigarette smoke exposure in the mouse is established in which mice are placed 6 at a time into a small animal plexiglass dosing chamber attached to a peristaltic pump whose intake is connected to a holder for a commercial unfiltered cigarette (Lucky Strike™). Along with fresh air, smoke is delivered into the chamber until the cigarette is consumed (approximately 5 minutes). Varying numbers of cigarettes (2-4 per day, 2-3 hr apart) are utilized for 1-3 consecutive days. Animals are euthanized by pentobarbital overdose approximately 18 hours after the final exposure. Bronchoalveolar lavage with phosphate-buffered saline is performed for inflammatory cell enumeration, and BAL aliquots and lungs are frozen for cytokine analysis. Smoke exposure results in time- and cigarette number- related increases in airway neutrophils, and lung chemokine (KC) and cytokine (IL- 6) content. To evaluate the role of a p38 MAP kinase inhibitor in this inflammatory response, mice are treated with a p38 kinase inhibitor, a compound of Formula (I) at approximately a 30 mg/kg, p.o. b.i.d.. Reduction in lung KC (a murine homologue of IL-8) levels are assessed 1 day after exposure (prior to neutrophilia), and attenuated airway neutrophilia and lung IL-6 levels are assessed following 3 days of cigarette exposure. Hypertussive Cough Models Described below is an example of how to determine the usefulness of p38 inhibitors in the treatment of hypertussive disorders or inflammation enhanced cough. The directed antitussive activity of the compound in question if first assessed, by a 10 to 30 minute pretreatment period by intraperitoneal injection or a 1 hour pretreatment period for oral administration. The animals (guinea pigs) are then subjected to an inhaled citric acid-induced cough challenge. The Citric Acid Induced Cough Model is shown in Figure 2. The effects of the compound are then assessed on the hypertussive response that occurs 72 hours post aerosol exposure to antigen or LTD4 exposure. Treatment of the animals occurs with the drag prior and/or after antigen or LTD4 challenge, but not on the day of citric acid challenge. The antigen or LTD4 induced hypertussive model is shown in Figure 3. The effects of known antitussive agents, dextromethorphan and codeine on Citric Acid Induced Cough in Guinea Pigs is shown in Figure 4. Inhalation of citric acid (CA; 0.4% for 1 minute) induces 11 to 15 coughs during the exposure and 12 -minute monitoring period in conscious guinea pigs. Exposure of sensitized animals to inhaled ovalbumin resulted in a hypertussive state (50-80% increae in CA-induced cough incidence) for several days, which positively correlated with airway esoinophilia determined by bronchoalveolar lavage. Similarly, inhalation of LTD4 (10 ug/ml for 1 minute) increases cough incidence and airway esoinophils 72 hours after exposure. Further explanation and details may be found in PCT/US00/25386, filed 15 September 2000 whose disclosure is incorporated by reference in its entirety. SYNTHETIC EXAMPLES The invention will now be described by reference to the following examples which are merely illustrative and are not to be constraed as a limitation of the scope of the present invention. All temperatures are given in degrees centigrade, all solvents are highest available purity and all reactions ran under anhydrous conditions in an argon atmosphere where necessary. Mass spectra were run on an open access LC-MS system using electrospray ionization. LC conditions: 4.5% to 90% CH 3 CN (0.02% TFA) in 3.2 min with a 0.4 min hold and 1.4 min re-equilibration; detection by MS, UN at 214, and a light scattering detector (ELS). Column: 1 X 40 mm Aquasil (C18) iH-ΝMR (hereinafter "NMR") spectra were recorded at 400 MHz using a Bruker. AM 400 spectrometer or a Braker AVANCE 400. Multiplicities indicated are: s=singlet, d=doublet, t=triplet, q=quartet, m=multiplet and br indicates a broad signal. Preparative (prep) hplc; ca 50 mg of the final products were injected in 500 uL of DMSO onto a 50 X 20 mm I. D. YMC CombiPrep ODS-A column at 20 mL/min with a 10 min gradient from 10% CH 3 CN (0.1% TFA) to 90% CH 3 CN (0.1% TFA) in H 2 O (0.1% TFA) and a 2 min hold. Flash chromatography is run over Merck Silica gel 60 (230 - 400 mesh). Accepted abbreviations are used as described in the ACS Style Guide (The ACS Style Guide. A Manual for Authors; Dodd, J. A., Ed.; American Chemical Society: Washington, DC, 1986; pp 47-69.). In addition the following are used: BOC t-butoxycarbonyl eq indicates the proportion of molar equivalents of a reagent relative to the principal reagent NMP l-methyl-2-pyrrolidinone satd saturated Rt hplc retention time Example 1 Preparation of 1 ,5-diphenyl-7-methylsulfanyl-3 ,4-dihydro- 1 H-pyrimido r4,5-d1pyrimidin- 2-one a) 4-Chloro-2-methylsulfanyl-6-phenylamino-pyrimidine-5-carbonitrile 4,6-Dichloro-2-methylsulfanyl-pyrimidine-5-carbonitrile [Santilli, et al., I. Heterocycl. Chem. 1971, 8, 445-453] (0.222 grams (hereinafter "g"), 1.0 millimoles (hereinafter "mmol")) in EtOH (2 mililiters (hereinafter "mL")) and Et 2 O (lmL) was treated with aniline (184 microliter (hereinafter "uL"), 2.0 mmol) in EtOH (1 mL). A clear solution formed initially but rapidly formed a heavy precipitate. The mixture was stirred 30 minutes (hereinafter "min") and was filtered, and the solid was washed with 1:1 Et 2 O, EtOH and then Et 2 O, dried to afford 162 miligrams (hereinafter "mg") (59%) of the title compound as a white solid. LC MS m/e = 277 (MH+), Rt = 2.32 min. b) 2-Methylsulfanyl-4-phenyl-6-phenylamino-pyrimidine-5-carbonitrile The product of the previous example, (162 mg, 0.59 mmol), phenylboronic acid (360 mg, 2.95 mmol), Na 2 CO 3 (318 mg, 3 mmol), dioxane (3 mL) and H 2 O (1.5 mL) were combined and argon was bubbled through the mixture for 30 min Pd[P(Ph) 3 ] (15 mg, 0.013 mmol) was added and the mixture was heated to 85° for 1.5 h, then cooled, diluted with H 2 O (25 mL) and extracted with EtOAc (6 X 50 mL). The combined extracts were washed with H 2 O, dried (Na 2 SO ), concentrated and filtered through a 10 g plug of silica (Varien bond elute ® ) with CH 2 C1 2 to afford the title compound as a white solid 185 mg (97%). LC MS m/e = 319 (MH+), Rt = 2.59 min. c) (5-Aπnnomethyl-2-methylsulfanyl-6-phenyl-pyrimidin-4-yl)-phenylamine. The product of the previous example (151 mg, 0.47 mmol) was dissolved in warm dioxane (6 mL), cooled to 23° and IM LAH in Et 2 O (1 mL, 1 mmol) was added and the resulting solution was heated to 55° for 1.5 h., diluted with EtOAc (10 mL) and then poured into 10% aq NaOH (20 mL) and extracted with more EtOAc (2 X 50 mL). The combined EtOAc was washed with H 2 O, then satd aq NaCl, dried (Na 2 SO ) and concentrated to afford the title compound as a yellow solid. 153 mg (100%). LC MS m/e = 323 (MH+), Rt = 1.49 min d) l,5-diphenyl-7-methylsulfanyl-3,4-dihydro-lH-pyrirnido[4,5-d]pyrimidin-2-one The product of the previous example (153 mg, 0.47 mmol) was dissolved in toluene (5 mL) and pyridine (2 mL). A 20% solution of COCl 2 in toluene (2 mL) was added and the resulting mixture was stirred 30 min, diluted with EtOAc (125 mL) and washed with 10% aq NaOH (20 mL) and H 2 O (5 X 20 mL) and concentrated. The crude product was purified by chromatotron chromatography (0 - 2 % MeOH in CH 2 C1 2 ) and then the resulting nearly pure yellow solid was further purified by prep hplc. The resulting white foam was dried in vacuo, triturated with H 2 O, and filtered and dried in vacuo to afford 33 mg of the title compound as a white powder. LC MS m/e = 349 (MH+), Rt = 2.12 min. Example 2 l-(2,6-difluorophenyl -5-(4-fluoro-2-methylphenyl)-7-methylsulfanyl-3,4-dihydro-lH- pyrimido[4,5-dlpyrimidin-2-one a) 4-Chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5- carbonitrile. 2,6-di-Fluoroaniline (2.66 mL, 24 mmol), DMSO (12 mL) and NaH (0.912 g, 22.8 mmol) were combined at 23°. When the foaming ceased 4,6-Dichloro-2- methylsulfanyl-pyrimidine-5-carbonitrile [Santilli, et al., J. Heterocycl. Chem. 1971, 8, 445-453] (5.0 g, 22.82 mmol) was added in DMSO (12 mL). The reaction exothermed and the temperature was moderated with cold H 2 O bath, then stirred at 23° for 3 h. The reaction was diluted with EtOAc (300 mL) and washed with H 2 O (4X) and satd aq NaCl (IX). Dried (Na 2 SO 4 ) and concentrated to afford 6.21 g (82%) of a tan foam. LC MS m/z = 313 (MH+ ), Rt = 2.37 min. b) 4-(2,6-Difluorophenylamino)-6-(4-fluoro-2-methylphenyl)-2- methylsulf anylpyrimidine-5 -carbonitrile . The product of the previous example (4.0 g, 12.8 mmol), 2-methyl-4- fmorophenylboronic acid (Lancaster) (5.91g, 38.4 mmol), Na 2 CO 3 (4.04 g, 38.4 mmol), dioxane (100 mL) and H 2 O (50 mL) were combined and a stream of argon was passed through the mixture for 15 min. Pd[P(Ph) 3 ] (Aldrich) (400 mg) was added and the mixture was heated to 85° for 6 h. EtOAc (600 mL) was added and the organic phase was washed with H 2 O (100 mL). The aq wash was extracted with EtOAc (2 X 75 mL) and the combined organic phases were washed with more H 2 O (50 mL) and satd aq NaCl (50 mL), dried (Na 2 SO 4 ), concentrated and the residue was flash chromatographed with CH 2 C1 2 . The desired fractions were pooled and concentrated in vacuo to afford 4.16 g (84%) of a tan foam. LC MS m/z = 387 (MH + ), Rt = 2.52 min c) 5-Aminomethyl-6-(4-fluoro-2-methylphenyl)-2-methylsulfanylpyrimidin -4-yl]- (2,6-difluorophenyl)amine. The product of the previous example (4.24 g, 11.0 mmol) was dissolved in Et 2 O (200 mL) and IM LAH in Et 2 O (22 mL) was added drop wise. After addition the mixture was heated to Et 2 O reflux for 1.5 h, cooled to 4° and quenched by the addition of H 2 O (1.1 mL), then 10% aq NaOH (5.5 mL) and then more H 2 O (5.5 mL), stirred 10 min then 2.5% CH 3 OH in CH 2 C1 2 (400 mL) was added. Stirred 15 min and the organic layer was decanted and the residue was washed with additional 2.5% methanolic CH 2 C1 2 (200 mL). The combined organic layers were dried (Na 2 SO 2 ) and concentrated to afford 4.02 g (94%) of a yellow foamy solid. LC MS m/z = 391 (MH + ), Rt = 1.62 min. d) 1 -(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-methylsulfanyl-3 ,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one The product of the previous example, (4.02 g, 10.4 mmol) was dissolved in THF (100 mL) and carbonyldiimidazole (2.23 g, 13.8 mmol) was added. The resulting mixture was stirred 16h, diluted with EtOAc (1 L) and washed with H 2 O (4 X 150 mL) and satd aq NaCl (150 mL), dried (Na 2 SO ) and concentrated to a brown foam. The residue was dissolved in CH 2 C1 2 and flash chromatographed in 0 - 2% CH 3 OH in CH 2 C1 2 to afford 2.97 g (69%) of the title compound as an off white solid. LC MS m/z = 417 (MH + ), Rt = 2.27 min. Example 3 l-(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-methylsulfonyl-3,4-dihydro- lH-pyrimidor4,5-d]pyrimidin-2-one The product of the preceeding example, example 2(2.14 g, 5.14 mmol), CH 2 C1 2 (100 mL) and metα-chloroperoxybenzoic acid (57 - 85%) (3.102 g, 10.26 mmol if 57%) were dissolved together. After 16 h, the reaction was diluted with EtOAc (300 mL) and washed with 5% aq Na 2 CO 3 (6 X 50 mL), H 2 O (50 mL) and satd aq NaCl (50 mL), dried Na 2 SO 2 and concentrated to afford 2.3 g (100 %) of the title compound as a white solid. LC MS m/z = 417 (MH + ), Rt = 1.94 min Example 4 l-(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(piperidin-4-ylamino)-3,4-dihvdro- lH-pyrimido[4,5-dlpyrimidin-2-one trifluoroacetate a) l-(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(l-tert-butoxycarbonyl- piperidin-4-ylaιιn^o)-3,4-dihydro-pyrirnido[4,5-d]pyrimidin-2-one The product of the previous example, Example 3 (90 mg, 0.2 mmol), NMP (1 mL) and 4-amino-l-BOC-piperidine (Astatech) (200 mg, 1.0 mmol) were heated in an oil bath at 65° for 16 h. The reaction was cooled to 23°, diluted with EtOAc (75 mL) and washed with 10 % aq citric acid (2X), H 2 O and satd aq NaCL, dried (Na 2 SO ), and concentrated to afford 112 mg of a white solid. LC MS m/z = 569 (MH + ), Rt = 2.14 min b) 1 -(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(piperidin-4-yIamino)-3 ,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one trifluoroacetate The product of the preceding example was dissolved in TFA (5 mL) and allowed to stand for 15 min, then concentrated and purified by prep hplc to afford 56.8 mg (61%) of a white powder. LC MS m/z = 469 (MH + ), Rt = 1.35 min Example 5 l-(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-dimethylaminoethylamino)-3,4- dihydro- lH-pyrimidor4,5-dlpyrimidin-2-one trifluoroacetate The product of example 3 (90 mg, 0.2 mmol) was dissolved in NMP (1 mL) and dimethylaminoethylamine (110 uL, 1.0 mmol) was added and the resulting brown soln was stirred on an oil bath heated to 65° for 16 h., diluted with EtOAc (75 mL) and washed with H 2 O (3X) and satd aq NaCl, dried (Na 2 SO ) concentrated and purified by prep hplc to afford 68 mg (75%). LC MS m/z = 457 (MH + ), Rt = 1.39 min Example 6 l-(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyI)-7-(l,3-dihvdroxyprop-2-ylamino)- 3,4-dihvdro-lH-pyrimido[4.5-d1pyrimidin-2-one The product of example 3 (90 mg, 0.2 mmol) was dissolved in NMP (1 mL) and serinol (91 mg, 1.0 mmol) was added. The solution was heated to 65° for 48 h, diluted with EtOAc (75 mL) and washed with 10% aq citric acid (2X), H 2 O, and satd aq NaCl, dried (Na SO ), concentrated and purified by prep hplc to afford 46 mg (50%). LC MS m/z = 460 (MH + ), Rt = 1.37 min The compounds in Table 1 were prepared by either the method of Example 5 (method A) or by the method of Example 6 (method B), using the appropriate amine. Note that Methods A and B differ by the absence (method A) or presence (method B) of an aqueous citric acid wash during work-up. For those examples where the reaction time and/or temperature was varied from v those given in Examples 5 and 6, the changes are indicated in Table 1, below. Table 1 Table 1 cont. Table 1 cont. 1. Using 40% aq dimethylamine. 2. Using 2M methylamine in THF. Example 31 1 -(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-methylsulfinyl-3 ,4-dihydro- 1 H- pyrimido r4.5~d]pyrimidin-2-one The product of example 2 (204 mg, 0.49 mmol) in THF was treated dropwise with oxone® (0.307 g, 0.5 mmol) in H 2 O (10 mL). The mixture was stirred at 23° for 2 h, diluted with EtOAc (100 mL) and washed with H 2 O (2 x 25 mL) and satd aq NaCl (25 mL), dried (Na 2 SO ), and concentrated. The residue was purified by prep hplc to afford the sulfoxide as a white powder. LC MS m/z = 433 (MH + ), Rt = 1.70 min Example 32 l-(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(l-methyl-lH-imidazol-2-yl-3,4- dihydro-lH-pyrimido[4.5-dlpyrimidin-2-one trifluoroacetate N-Methylimidazole (82 uL, 1.0 mmol) in dry THF was cooled to -70° and n-butyl lithium (2.5 M in hexane) (0.36 mL, 0.9 mmol) was added, the mixture was stirred 15 min and then the product of example 3 (45 mg, 0.1 mmol) was added and the reaction was warmed to 23°, and stirred 30 min. The reaction was poured into satd aq NaHCO 3 (20 mL) and stirred 5 min and then extracted with EtOAc (2 X). The combined EtOAc was washed with H 2 O (3X), satd aq NaCl, dried (Na 2 SO ) and concentrated. The residue was purified by prep hplc to afford 11.6 mg (26%) of the title compound as a white powder. LC MS m/z = 451 (MH + ), Rt = 1.55 min. Example 33 l-(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(l-piperazin-4-yl)- 3,4-dihvdro-lH-pyrimido[4,5-d]pyrimidin-2-one The title compound was prepared by the method of example 4 except that 1-BOC- piperazine (Fluka) was the amine. TFA deblocking of the intermediate BOC protected compound as in example 4 and prep hplc afforded the the title compound as a white powder. LC MS m/z = 455 (MH + ), Rt = 1.55 min. Example 34 1 -(2,6-difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(4-carboxypiperidin- 1 -ylV 3 ,4-dihydro- 1 H-pyrimido [4,5-dlpyrimidin-2-one The product of example 11 (56 mg, 0.11 mmol) was dissolved in THF (2 mL) and LiOH (24 mg, 1.0 mmol) in H 2 O (1.0 mL) was added, and the resultiing soln was stirred for 4 h. The reaction was concentrated and redissolved in DMSO and purified by prep hplc to afford 24.8 mg (45%) of the title compond. LC MS m z = 498 (MH + ), Rt = 1.64 min. The sulfides in examples 35 to 37 (Table 2) were prepared by the method of Example 2, except that the boronic acid in step 2b was varied as depicted in Table 2. below. Table 2 The sulfides in examples 38 - 44 (Table 3) were prepared by the method of Example 2 except that the amine in step 2a was varied as depicted in Table 3, below. Table 3 Table 3 cont. The sulfones in Table 4 were made by the procedure of Example 3 except that the substrate sulfides were the products of the examples indicated. Table 4 Table 4 cont. * the substrate is the product of the noted example # Example 55 1 -(2,6-Difluorophenyl)- 5-phenyl-7-(4-methylpiperazin- 1 -yl)-3 ,4-dihydro- 1 H- pyrimido [4,5-d1pyrimidin-2-one The product of example 45 (41.6 mg, 0.1 mmol), 4-methylpiperazine (30 mg, 0.3 mmol) and NMP (1.0 mL) were dissolved together and heated to 65° for 18 h. The NMP was removed in high vacuum and the residue was purified by prep hplc to afford 17 mg of the title compound. LC MS m/z = 437 (MH + ), Rt = 1.47 min. Example 56 l-(2,6-Difluorophenyl)- 5-phenyl-7-piperazin-l-yl-3,4-dihydro-lH-pyrimido[4,5- d]pyrimidin-2-one The product of example 45 (41.6 mg, 0.1 mmol), and 1-BOC-piperazine (Fluka) were treated by the method of example 55, omitting the hplc step, to afford the BOC protected intermediate. This product was deblocked by the procedure of example 4b and purified by prep hplc to afford the title compound. LC MS m/z = 422 (MH + ), Rt = 1.37 min. The compounds in Table 5 were prepared by either the method of Example 5, using the appropriate amine and the sulfone shown in Table 5 (Method C; includes aqueous work- up), or the method of Example 55 using the appropriate amine and the sulfone shown in Table 5 (Method D; with concentration of the crude reaction mixture, then preperation hplc), or the method of Example 33 using the appropriate sulfone (Method E; aq. work- up with citric acid, deblocking, and prep hplc) or the method of Example 56 using the appropriate sulfone as shown in Table 5 (Method F; concentration, deblocking, and prep hplc). In the table, method* is the the substrate is the sulfone of the noted example. Table 5 Table 5 cont. Example 72 1 -(2,6-difluorophenyl)-5-phenyl-7-( 1 -methyl- 1 H-imidazol-2-yl- 3,4-dihvdro-lH-pyrimido[4,5-d]pyrimidin-2-one trifluoroacetate The product of example 45 was converted to the target compound by the procedure of example 32. LC MS m/z = 419 (MH 4 ), Rt = 1.42 min Example 73 1 -(2,6-difluorophenyl)-5-f 4-fluorophenyl)-7-( 1 -methyl- lH-imidazol-2-y)l-3 ,4-dihydro- lH-pyrimido[4,5-d]pyrimidin-2-one trifluoroacetate The product of example 46 was converted to the target compound by the procedure of example 32. LC MS m/z = 437, (MH + ), Rt = 1.44 min. Example 74 1 -(2,6-difluorophenyl)-5-phenyl-7-(4-carboxypiperidin- 1 -yl)-3 ,4-dihydro- 1 H- pyrimido [4,5-d1pyrimidin-2-one trifluoroacetate The product of example 60 was converted to the target compound by the procedure of example 34. LC MS m z = 466 (MH+), Rt = 2.39 min Example 75 1 -(2,6-difluorophenyl)-5-(4-fluorophenyl)-7-(4-carboxypiperidin- 1 -yl)-3 ,4-dihydro- 1H- pyrimido[4,5-d1pyrimidin-2-one trifluoroacetate The product of example 67 was converted to the target compound by the procedure of example 34. LC MS m/z = 484 (MH+), Rt = 1.95 min Example 76 1 -(2-Chlorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-pyrrolidin- 1 -yl-ethylamino)-3 ,4- dihydro- lH-pyrimidido[4,5-dlpyrimidin-2- one . The product of example 50 (75 mg, 0.168 mmol), pyrollidin-1-yl ethylamine (57mg, 0,5 mmol) were combined in a sealed tube at 90° for 20 h. Concentration and prep hplc afforded the title compound as an amber oil. LC MS m/z = 480 (MH+), Rt = 1.52 min Example 77 l-(2-Chlorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(lH-tetrazol-5-ylamino -3,4-dihvdro- lH-pyrimido[4,5-d]pyrimidin-one The method of example 76 was repeated except using 5-aminotetrazole as the amine and the reaction was heated to 150° for 10 h. Concentration and prep hplc afforded the title compound as an amber oil. LC MS m/z = 450 (MH+), Rt = 1.94 min. The compounds in Table 6 were prepared by either the method of Example 76 (method G) or the method of Example 77 (method H) using the appropriate amine and the sulphone of the example indicated. Table 6 Table 6 cont. Table 6 cont. Table 6 cont. Table 6 cont. Table 6 cont. Table 65 cont. * the sulfone product of the exemplified example number; a. The reactant amine was 1-Boc-piperazine. The Boc group in this case was removed during the reaction. Example 148 l-f2-Methylphenyl)- 5-(4-fluoro-2-methylphenyl)-7-(l-ethylpiperidin-4-ylamino)-3,4- dihydro-lH-pyrimidor4,5-d]pyrimidin-one The product of example 52 (75 mg, 0.17 mmol), l-ethylpiperidin-4-ylamine hydrochloride (100 mg, 0.5 mmol), K 2 CO 3 (83 mg, 0.6 mmol) and NMP (1 mL) were combined and heated to 150° in a sealed tube for 10 h. Concentration and prep hplc afforded the title compound as an amber oil. LC MS m/z = 475 (MH+), Rt = 1.42 min Example 149 1 -(2-Fluorophenyl)- 5-(4-fluoro-2-methylphenyl)-7-( 1 -methylpiperidm-4-ylamino)-3 ,4- dihydro-lH-pyrimido[4,5-d1pyrimidin-one The product of example 54 (75 mg, 0.17 mmol), l-methylpiperidin-4-ylamine hydrochloride (94 mg, 0.5 mmol), K 2 CO 3 (83 mg, 0.6 mmol) and NMP (1 mL) were combined and heated to 90° in a sealed tube for lOh. Concentration and prep hplc afforded the title compound as an amber oil. LC MS m/z = 465 (MH+), Rt = 1.49 min. The products of the examples in Table 7 are made by either the method of example 148 (Method I) or the method of example 149 (Method J) using the sulfone product from Table 4 as indicated and the appropriate amine hydrochloride. Table 7 Table 7 cont. * the sulfone product of the exemplified example number a. The starting amine is glycine tert-butyl ester. The ester is cleaved under the reaction conditions. Example 161 l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-methoxy-3,4-dihydro-lH- pyrimido[4,5-d]pyrimidm-2-one The product of Example 3 (0.102 g, 0.22 mmol) was suspended in MeOH (2 mL) and stirred under argon. A 1 Molar solution of NaOMe in methanol (0.44 mL, 0.44 mmol) was added. After 10 min the solvent was removed in vacuo, and the residue partitioned between EtOAc and H 2 O. The organic phase was washed with H 2 O (2 X), satd aq NaCl (1 X), dried over anhydrous Na 2 SO , filtered, and evaporated to give the crade product. Recrystallization from EtOAc/hexane gave the title compound as a white- crystalline solid, mp 210-211°C, LC MS m/z = 401 (MH+) Rt = 2.0 min. Example 162 l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-ethoxy-3,4-dihydro-lH- pyrimido[4,5-d1pyrimidin-2-one The product of Example 3 (0.0658 g, 0.147 mmol) was suspended in EtOH (2 mL) and stirred under argon. A 0.5 M solution of NaOEt in EtOH (0.587 mL, 0.294 mmol) was added. After 15 min the solvent was removed in vacuo, and the residue partitioned between EtOAc and H 2 O. The organic phase was washed with H 2 O (2 X), satd aq NaCl (1 X), dried over anhydrous Na 2 SO , filtered, and evaporated to give the crade product. Flash chromatography on silica gel eluted with 0-5% EtOAc/CH 2 Cl 2 gave the title compound as a white-amorphous solid, mp 191-194°C, LC MS m/z = 415 (MH+) Rt = 2.15 min. Example 163 l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-hvdroxyethoxy)-3,4-dihydro- lH-pyrimidor4,5-d1pyrimidin-2-one The product of Example 3 (0.0658 g, 0.147 mmol) was suspended in ethylene glycol (1 mL) and stirred under argon. NaH, dry, 95%, (8.0 mg, 0.32 mmol) was added. After 30 min the solvent was removed in vacuo, and the residue partitioned between EtOAc and H 2 O. The organic phase was washed with H 2 O (2 X), satd aq NaCl (1 X), dried over anhydrous Na 2 SO , filtered, and evaporated to give the crude product. Flash chromatography on silica gel eluted with 0-10% EtOAc/CH 2 Cl 2 gave the title compound as a white-amorphous solid, mp 172-175°C, LC MS m/z = 431 (MH+) Rt = 1.7 min. Example 164 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-( 1 -methyrpiperidin-4-yloxy)-3 ,4- dihydro- lH-pyrimidor4,5-dlpyrimidin-2-one trifluoroacetate A solution of 4-hydroxy-l-methylpiperidine (35.1 mg, 0.3 mmol) in DMSO (0.25 ml) was stirred under argon and NaH, dry, 95%, (7.5 mg, 0.3 mmol) was added. The mixture was stirred for 15 min, and then a solution of the product of Example 3 (0.0672 g, 0.15 mmol) dissolved in DMSO (0.25 mL) was added. After the mixture was stirred for 30 min, the reaction mixture was partitioned between EtOAc and H2O. The organic phase was washed with H 2 O (5 X), satd aq NaCl (1 X), dried over anhydrous Na 2 SO , filtered, and evaporated to give the crude product. Purification by preparative hplc followed by lyophillization gave the title compound as a white-amorphous solid. LC MS m/z = 484 (MH+) Rt = 1.47 min. Example 165 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7- r [bis- (2-hydroxyethyl)aminolethoxy1-3,4-dihydro-lH-pyrimido[4,5-d1pyrimidin-2-one trifluoroacetate NaH, dry, 95%, (8 mg, 0.4 mmol) was added to triethanolamine (243 mg, 1.6 mmol), and then DMSO (0.25 ml) was added. The mixture agitated for 2 min., and then the product of Example 3 (0.0896 g, 0.2 mmol) was added. After 5 min of agitation, additional DMSO (0.25 mL) was added. After the mixture was agitated for 10 min, the reaction mixture was partitioned between EtOAc and H2O The organic phase was washed with H 2 O (5 X), satd aq NaCl (1 X), dried over anhydrous Na 2 SO 4 , filtered, and evaporated to give the crude product. Purification by preparative hplc followed by * lyophillization gave the title compound as a white-amorphous solid. LC MS m/z = 518 (MH+) Rt = 1.25 min. Example 166 l-(2,6-Difluorophenyl)-5-phenyl-7-methoxy-3,4-dihydro-lH-pyrimidor4,5-dlpyrimidin- 2-one Following the procedure of example 161 except using the product of example 45 in place of the product of example 3 gave the title compound as a white-crystalline solid, mp 221-224°C, LC MS m/z = 369 (MH+) Rt = 1.92 min. Example 167 1 ,5-diphenyl-7-methoxy-3 ,4-dihydro- 1 H-pyrimido r4,5-d]pyrimidin-2-one a) 1 -(2,6-difluorophenyl)-5-phenyl-7-methylsulfonyl-3 ,4-dihydro- lH-pyrimido[4,5-d]pyrimidin-2-one Following the procedure of example 3 except for using the product of example 1 in place of the product of example 2 gave the title compound as a white solid. LC MS m/z = 381 (MH+) Rt = 1.78 min. b) l,5-diphenyl-7-methoxy-3,4-dihydro-lH-pyrimido[4,5-d1pyrimidin-2-one Following the procedure of example 161 except using the product of example 167 (a) in place of the product of example 3 gave the title compound as a white-amorphous solid, mp 220-222°C, LC MS m/z = 333 (MH+) Rt = 1.94 min. All publications, including but not limited to patents and patent applications, cited in this specification are herein incorporated by reference as if each individual publication were specifically and individually indicated to be incorporated by reference herein as though fully set forth. The above description fully discloses the invention including preferred embodiments thereof. Modifications and improvements of the embodiments specifically disclosed herein are within the scope of the following claims. Without further elaboration, it is believed that one skilled in the are can, using the preceding description, utilize the present invention to its fullest extent. Therefore, the Examples herein are to be construed as merely illustrative and not a limitation of the scope of the present invention in any way. The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows.

Claims: What is Claimed is: 1. A compound of the formula: wherein Rl is a aryl or a heteroaryl ring, which ring is optionally substituted; R2 is hydrogen, C * _ιo alkyl, C3_7cycloalkyl, C3-.7cycloalkylC1.-1 oalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC _ 10 alkyl moiety; and wherein each of these moieties, excluding hydrogen, are optionally substituted; R3 is a Cι_ιo alkyl, C 3.7 cycloalkyl, C3_7cycloalkylCι_ιoalkyl, aryl, arylCι_ιoalkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or a heterocyclylC ι_ 10 alkyl moiety; and wherein each of these moieties are optionally substituted; Y is a bond, CRf,, C(O), Ν(Rd), oxygen, or S(O)m; R * b is hydrogen, C _2 alkyl, NR C , hydroxy, thio, C ι_2 alkoxy, or S(O) m Cι_2 alkyl; R c is hydrogen or Cχ_2 alkyl; Rd is hydrogen or Cι_2 alkyl; X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n NR 4 Rι 4j or (CH 2 ) n NR 2 R4; m is 0 or an integer having a value of 1 or 2; n is 0 or an integer having a value of 1 to 10; R4 and R 14 are each independently selected from hydrogen, optionally substituted Ci-6 alkyl, optionally substituted aryl or an optionally substituted aryl-Ci-4 alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and wherein the ring is optionally substituted; R6 is hydrogen, Ci-io alkyl, C3-7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or a heteroarylCi-lθ alkyl moiety; and wherein each of these moieties, excluding hydrogen, is optionally substituted; R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl or optionally substituted arylCi-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. 2. The compound according to Claim 1 wherein the structure is of Formula (IV). 3. The compound according to Claim 1 wherein R3 is an optionally substituted aryl, arylCi-ioalkyl, or a cycloalkyl moiety. 4. The compound according to Claim wherein R is an optionally substituted aryl moiety. 5. The compound according to any one of Claims 3 or 4 wherein the moiety is optional substituted one or more times, independently by halogen, alkyl, hydroxy, alkoxy, amino, or halosubstituted alkyl. 6. The compound according to any one of Claims 1 to 5 wherein X is OR2. 7. The compound according to any one of Claims 1 to 5 wherein X is S(O) m R2- 8. The compound according to any one of Claims 1 to 5 wherein X is (CH 2 ) n NR 4 Ri4. 9. The compound according to any one of Claims 1 to 5 wherein X is (CH2) n NR2- 10. The compound according to any one of Claims 1 to 5 wherein X is R2. 11. The compound according to any one of Claims 1 to 10 wherein Y is CR D , or C(O). 12. The compound according to any one of Claims 1 to 10 wherein Y is N(R ( i), oxygen, or S(O)m. 13. The compound according to any one of Claims 1 to 10 wherein Y is a bond. 14. The compound according to any one of Claims 1 to 13 wherein R2 is an optionally substituted alkyl, heteroaryl, or heterocyclic or heterocyclic alkyl. 15. The compound according to Claim 14 wherein R2 is an optionally substituted imidazole, tetrazole, pyrrolidine, piperidine, piperazine, or morpholine ring. 16. The compound according to Claim 15 wherein the ring is substituted one or more times, independently, by halogen, Cχ_ιoalkyl, halosubstituted C _ιo lkyl, (CR 10 R 2 0)nNR4Rl4> (CRιoR2θ)nOR6> or (CRι 0 R 2 θ)nC(Z)OR 6 . 17. The compound according to Claim 1 which is 7-Methylsulfanyl-l,5-diphenyl-3,4-dihydro-lH-pyrimido[4,5--i]pyrimidin-2-one l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-methylsulfanyl-3,4-dihydro- lΗ-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-methylsulfonyl-3,4-dihydro- 1 H-pyrimido [4,5 -d]pyrimidin-2-one ; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-piperidin-4-ylamino)-3,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one trifluoroacetate; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-l,3-dihydroxyprop-2-yl- amino)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 5-(4-Fluoro-2-methylphenyl)-7-methylsulf anyl- 1 -((R)- 1 -phenylethyl)-3 ,4-dihydro- lH-pyrimido[4,5-d]pyrimidin-2-one; 5-(4-Fluoro-2-methylphenyl)-7-methylsulfanyl- 1-((S)-1 -phenylethyl)-3 ,4-dihydro- lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(l-methylpiperazin-4-yl)-3,4- dihydro- 1 H-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-( 1 -methylpiperazin-4-yl)-3 ,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(l-methyl-lH-imidazol-2-yl- 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(imidazol-lyl-)3,4-dihydro- lH-pyrirnido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-7-methylsulfanyl-5-phenyl-3,4-dihydro-lH-pyrimido[4,5-d]- pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-7-methylsulf anyl-5-(4-fluorophenyl)-3 ,4-dihydro- 1 H- pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-([2-hydroxyethyl)- methylamino]-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-( 1 -piperazin-4-yl)-3 ,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(4-hydroxypiperdin- 1 -yl)- ' < 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(4-carboxypiperidin- 1 -yl)- 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(4-carboethoxypiperidin- 1 - yl)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; I 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(4-hydroxymethylpiperdin- 1 - yl)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidm-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-di(ethan-2-ol-)amino-3,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-( 1 -methylpiperidin-4-yl- > amino)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(l-morpholin-4-yl)-3,4- dihydro- 1 H-pyrimido [4,5 -d]pyrimidin-2-one ; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-morpholin-4-yl ethylamino)- 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; ) 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-pyrrolidin- 1 -yl ethylamino)- 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-piperidin-l-yl ethylamino)- 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; SB-647851 -M l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-pyridin-3-yl ethylamino)- > 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-diethylamino ethylamino)- 3 ,4-dihydro- 1 H-pyrimido [4,5 -d]pyrimidin-2-one ; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-pyridin-3-yl ethylamino)- 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; I 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2- dimethylamino)-3 ,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one ; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2- methylamino)-3 ,4-dihydro- lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(2-methylphenyl)-7-methylsulfanyl-3,4-dihydro-lH- i pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(2-methylphenyl)-7-( 1 -piperazin-4-yl)-3 ,4-dihydro- 1H- pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(2-methylphenyl)-7-(2-diethylamino ethylamino)-3 ,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-phenyl-7-methoxy-3 ,4-dihydro- 1 H-pyrimido [4,5-d]- pyrimidin-2-one; l-(2-Fluorophenyl)-7-methylsulfanyl-5-(2-methyl-4-fluoro)phenyl-3,4-dihydro-lH- pyrirnido[4,5-d]pyrirnidin-2-one; l-(2,6-Dimethylphenyl)-7-methylsulfanyl-5-(2-methyl-4-fluoro)phenyl-3,4-dihydro- 1 H-pyrimido [4,5-d]pyrimidin-2-one; l-(2-Methylρhenyl)-7-methylsulfanyl-5-(2-methyl-4-fluoro)ρhenyl-3,4-dihydro-lH- pyrimido[4,5-d]pyrimidin-2-one; l-Cyclohexyl-7-methylsulfanyl-5-(2-methyl-4-fluoro)phenyl-3,4-dihydro-lH- pyrimido[4,5-d]pyrimidin-2-one; 1 -(2-Chlorophenyl)-7-methylsulfanyl-5-(2-methyl-4-fluoro)phenyl-3 ,4-dihydro- 1H- pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-methyl- 1 ,3-dihydroxyprop- 2-ylamino)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl-7-ethoxy-3,4-dihydro-lH- pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-((R)-2-hydroxy- 1 -methyl- ethylamino)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-((S)-2-hydroxy-l-methyl- ethylamino)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-hydroxy- 1 , 1 -dimethyl- ethylamino)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; 1 -(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-hydroxy- 1 , 1 -bis-hydroxy- methyl-ethylaιmno)-3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2-hydroxyethylamino)-3,4- dihy dro- 1 H-pyrimido [4,5-d]pyrimidin-2-one ; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl-7-(l-methylpiperidin-4-yloxy)- 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l,5-Diphenyl-7-methoxy-3,4-dihydro-lH-pyrirmdo[4,5-d]pyrirnidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl-7-(2-hydroxyethoxy)-3,4- dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-[[bis-(2-hydroxyethyl)- amino]ethoxy]-3,4-dihydro- lH-pyrimido[4,5-d]pyrimidin-2-one; l-(2,6-Difluorophenyl)-5-(4-fluoro-2-methylphenyl)-7-(2,3-dihydroxypropylamino)- 3,4-dihydro-lH-pyrimido[4,5-d]pyrimidin-2-one; or a pharmaceutically acceptable salt thereof. 18. A pharmaceutical composition comprising a compound according to any one of Claims 1 to 17, and a pharmaceutically acceptable carrier or diluent. 19. A method of treating, including prophylaxis, of a CSBP/RK/p38 kinase mediated disease in a mammal in need thereof, which method comprises administering to said mammal an effective amount of a compound of according to any one of Claims 1 to 17. 20. The method according to Claim 19 wherein the CSBP/RK7p38 kinase mediated disease is psoriatic arthritis, Reiter's syndrome, gout, traumatic arthritis, rubella arthritis, acute synovitis, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic condition, sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, cerebral malaria, meningitis, ischemic and hemorrhagic stroke, neurotrauma/closed head injury, asthma, adult respiratory distress syndrome, chronic pulmonary inflammatory disease, chronic obstructive pulmonary disease, silicosis, pulmonary sarcososis, bone resorption disease, osteoporosis, restenosis, cardiac and brain and renal reperfusion injury, congestive heart failure, coronary arterial bypass grafting (CABG) surgery, thrombosis, glomeralamephritis, chronic renal failure, diabetes, diabetic retinopathy, macular degeneration, graft vs. host reaction, allograft rejection, inflammatory bowel disease, Crohn's disease, ulcerative colitis, neurodegenrative disease, muscle degeneration, diabetic retinopathy, macular degeneration, tumor growth and metastasis, angiogenic disease, influenza induced pneumonia, eczema, contact dermatitis, psoriasis, sunburn, or conjunctivitis. 21. A compound of the formula wherein Rl is an aryl or heteroaryl ring, which ring is optionally substituted; R2 is hydrogen, CI_IQ alkyl, C 3.7 cycloalkyl, C 3.7 cycloalkylalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ o alkyl, heterocyclic, or heterocyclylC ι_χo alkyl moiety; and wherein each of these moieties, excluding hydrogen, are optionally substituted; R3 is Cι_ιo alkyl, C 3.7 cycloalkyl, C 3.7 cycloalkyl Cι_χo alkyl, arylCι_ιo alkyl, heteroarylCι_ιo alkyl, heterocyclylC I_IQ alkyl moiety; and wherein each of these moieties are optionally substituted; X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n NR 4 Rι 4 , or (CH 2 ) n NR 2 R4; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; R4 and R14 are each independently selected from hydrogen, optionally substituted Ci-4 alkyl, optionally substituted aryl or an optionally substituted aryl-Ci_4 alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9; R6 is hydrogen, Ci-io alkyl, C3-7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or heteroarylCi-io alkyl; and wherein each of these moieties, excluding hydrogen, may be optionally substituted; R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl or optionally substituted aryl-Ci-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. 22. The compound according to Claim 21 wherein the structure is of Formula (I). 23. The compound according to Claim 22 wherein Rl and/or R3 are an optionally substituted aryl. 24. The compound according to Claim 23 wherein the aryl is substituted one or more times, independently, by halogen, alkyl, hydroxy, alkoxy, amino, or halosubstituted alkyl. 25. The compound according to any one of Claims 21 to 24 wherein X is R2, OR2, or S(O) m R 2 . 26. The compound according to any one of Claims 21 to 24 wherein X is (CH2) n NR4R14, or (CH 2 ) n NR2R4. 27. The compound according to Claim 21, which is: 7-Methylsulfanyl-5-phenyl- 1 -( 1 -phenylethyl)-3 ,4-dihydro- lH-pyrimido[4,5-J]- pyrimidin-2-one; or a pharmaceutically acceptable salt thereof. 28. A pharmaceutical composition comprising a compound according to any one of Claims 21 to 27, and a pharmaceutically acceptable carrier or diluent. 29. A method of treating a CSBP/RK/p38 kinase mediated disease in a mammal in need thereof, which method comprises administering to said mammal an effective amount of a compound of Formula (I) or (la) according to any one of Claims 21 to 27. 30. The method according to Claim 29 wherein the CSBP/RK/p38 kinase mediated disease is psoriatic arthritis, Reiter's syndrome, gout, traumatic arthritis, rubella arthritis, acute synovitis, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic condition, sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, cerebral malaria, meningitis, ischemic and hemorrhagic stroke, neurotrauma/closed head injury, asthma, adult respiratory distress syndrome, chronic pulmonary inflammatory disease, chronic obstructive pulmonary disease, silicosis, pulmonary sarcososis, bone resorption disease, osteoporosis, restenosis, cardiac and brain and renal reperfusion injury, congestive heart failure, coronary arterial bypass grafting (CABG) surgery, thrombosis, glomeralamephritis, chronic renal failure, diabetes, diabetic retinopathy, macular degeneration, graft vs. host reaction, allograft rejection, inflammatory bowel disease, Crohn's disease, ulcerative colitis, neurodegenrative disease, muscle degeneration, diabetic retinopathy, macular degeneration, tumor growth and metastasis, angiogenic disease, influenza induced pneumonia, eczema, contact dermatitis, psoriasis, sunburn, or conjunctivitis. 31. A compound of the formula: Rl is an aryl or heteroaryl ring, which ring is optionally substituted; R2 is hydrogen, Cι_ιo alkyl, C 3.7 cycloalkyl, C 3.7 cycloalkylalkyl, aryl, arylCi- 10 alkyl, heteroaryl, heteroarylCι_ιo alkyl, heterocyclic, or heterocyclylC _ 10 alkyl moiety; and wherein each of these moieties, excluding hydrogen, are optionally substituted; R3 is an Cι_ιo alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι_ o alkyl, heterocyclic, or heterocyclylCi-io ^kyl moiety; and wherein each of these moieties are optionally substituted; Y is CRfc, C(O), N(Rd), oxygen, or S(O)m; R * b is hydrogen, Cι_2 alkyl, NR C , hydroxy, thio, C ι_ alkoxy, S(O) m Cι_2 alkyl, R c is hydrogen or Cι_2 alkyl; Rd is hydrogen or Cι_2 alkyl; X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n NR 4 Rι 4j or (CH 2 ) n NR 2 R4; m is 0 or an integer having a value of 1 or 2; n is 0 or an integer having a value of 1 to 10; R4 and R14 are each independently selected from hydrogen, optionally substituted Ci-4 alkyl, optionally substituted aryl or an optionally substituted aryl-Ci-4 alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9; Rβ is hydrogen, Ci-io alkyl, C3-7 cycloalkyl, heterocyclyl, heterocyclyl Cι_ιoalkyl, aryl, arylCi-io alkyl, heteroaryl or heteroarylCi-io alkyl; and wherein each of these moieties, excluding hydrogen, may be optionally substituted; R9 is hydrogen, C(Z)Rβ or optionally substituted Ci_io alkyl, optionally substituted aryl or optionally substituted aryl-Ci-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. 32. The compound according to Claim 31 wherein the structure is of Formula (II). 33. The compound according to Claim 31 wherein Rl and/or R3 is an optionally substituted aryl. 34. The compound according to Claim 33 wherein the aryl is substituted one or more time, independently, by halogen, alkyl, hydroxy, alkoxy, amino, or halosubstituted alkyl. 35. The compound according to Claim 31 wherein X is R2, OR2, or S(O) m R2. 36. The compound according to Claim 31 wherein X is or (CH2) NR4R14, or (CH 2 ) n NR 2 R 4 . 37. The compound according to any one of Claims 31 to 36 wherein R2 is an optionally substituted heteroaryl or heterocyclic. 38. A pharmaceutical composition comprising a compound according to any one of Claims 31 to 37, and a pharmaceutically acceptable carrier or diluent. 39. A method of treating a CSBP/RK7p38 kinase mediated disease in a mammal in need thereof, which method comprises administering to said mammal an effective amount of a compound of Formula (II) or (Ha) according to any one of Claims 31 to 37. 40. The method according to Claim 39 wherein the CSBP/RK/p38 kinase mediated disease is psoriatic arthritis, Reiter's syndrome, gout, traumatic arthritis, rubella arthritis, acute synovitis, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic condition, sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, cerebral malaria, meningitis, ischemic and hemorrhagic stroke, neurotrauma/closed head injury, asthma, adult respiratory distress syndrome, chronic pulmonary inflammatory disease, chronic obstructive pulmonary disease, silicosis, pulmonary sarcososis, bone resorption disease, osteoporosis, restenosis, cardiac and brain and renal reperfusion injury, congestive heart failure, coronary arterial bypass grafting (CABG) surgery, thrombosis, glomeralamephritis, chronic renal failure, diabetes, diabetic retinopathy, macular degeneration, graft vs. host reaction, allograft rejection, inflammatory bowel disease, Crohn's disease, ulcerative colitis, neurodegenrative disease, muscle degeneration, diabetic retinopathy, macular degeneration, tumor growth and metastasis, angiogenic disease, influenza induced pneumonia, eczema, contact dermatitis, psoriasis, sunburn, or conjunctivitis. 41. A compound of the formula wherein Rl is an aryl, or a heteroaryl ring, which ring is optionally substituted; R2 is a heterocyclic or heterocyclicC ι_ιo alkyl ring, which is ring is optionally substituted; R2' s a heterocyclic, heterocyclicC J_J alkyl, aryl, or heteroaryl ring, which ring is optionally substituted; R3 is an aryl or heteroaryl ring, which ring is optionally substituted; X is R2', OR2, S(O) m R2 or (CH2) n NR4R 4 ; or (CH2) n NR2R4; provided that when X is (CH2) n NR4R14, then R4R14 must form the optionally substituted cyclized ring optionally comprising an oxygen, sulfur or nitrogen moiety; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; R4 and R14 are independently selected from hydrogen, optionally substituted Ci_4 alkyl, optionally substituted aryl, or optionally substituted arylCi-4 alkyl; or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9, and which ring is optionally substituted; R6 is hydrogen, Ci-io alkyl, C3-7 cycloalkyl, heterocyclyl, heterocyclyl Ci_ioalkyl, aryl, arylCi-io alkyl, heteroaryl or a heteroarylCi-io alkyl moiety; and wherein each of these moieties, excluding hydrogen, is optionally substituted; R9 is hydrogen, C(Z)R6, optionally substituted Cι_ιo alkyl, optionally substituted aryl, or optionally substituted arylCi-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. 42. The compound according to Claim 41 wherein the structure is of Formula (III). 43. The compound according to Claim 41 wherein Ri and/or R3 is an optionally substituted aryl. 44 The compound according to Claim 43 wherein the aryl is substituted one or more times, independently by halogen, alkyl, hydroxy, alkoxy, amino, or halosubstituted alkyl. 45. The compound according to Claim 42 wherein X is OR , or S(O) m R2- 46 . The compound according to Claim 42 wherein X is (CH2) n NR4R^ or (CH2) n NR 2 R 4 . 47. The compound according to Claim 42 wherein X is R2'. 48. The compound according to Claim 47 wherein R2' is an optionally substituted heteroaryl or heterocyclic ring. 49. The compound according to Claim 48 wherein the ring is an optionally substituted imidazole, pyrrolidine, piperidine, piperazine, or a morpholine ring. 50. The compound according to Claim 49 wherein the ring is substituted one or more times, independently, by halogen, Cι_ιoalkyl, halosubstituted Cι_ιoalkyl, (CRι 0 R20) n NR4Rl4> (CRι 0 R2θ)nOR6, and (CRι 0 R2θ) n C(Z)OR 6 . 51. A pharmaceutical composition comprising a compound according to any one of Claims 41 to 50, and a pharmaceutically acceptable carrier or diluent. 52. A method of treating a CSBP/RK7p38 kinase mediated disease in a mammal in need thereof, which method comprises administering to said mammal an effective amount of a compound of Formula (III) or (Ilia) according to any one of Claims 41 to 50. 53. The method according to Claim 52 wherein the CSBP/RK/p38 kinase mediated disease is psoriatic arthritis, Reiter's syndrome, gout, traumatic arthritis, rubella arthritis, acute synovitis, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic condition, sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, cerebral malaria, meningitis, ischemic and hemorrhagic stroke, neurotrauma/closed head injury, asthma, adult respiratory distress syndrome, chronic pulmonary inflammatory disease, chronic obstructive pulmonary disease, silicosis, pulmonary sarcososis, bone resorption disease, osteoporosis, restenosis, cardiac and brain and renal reperfusion injury, congestive heart failure, coronary arterial bypass grafting (CABG) surgery, thrombosis, glomeralamephritis, chronic renal failure, diabetes, diabetic retinopathy, macular degeneration, graft vs. host reaction, allograft rejection, inflammatory bowel disease, Crohn's disease, ulcerative colitis, neurodegenrative disease, muscle degeneration, diabetic retinopathy, macular degeneration, tumor growth and metastasis, angiogenic disease, influenza induced pneumonia, eczema, contact dermatitis, psoriasis, sunburn, or conjunctivitis. 54. A compound of the formula: wherein X is R 2 , OR 2 , S(O) m R 2 or (CH 2 ) n ΝR 4 Rι 4; or (CH 2 ) n NR 2 R 4 ; n is 0 or an integer having a value of 1 to 10; m is 0 or an integer having a value of 1 or 2; Rl is an optionally substituted aryl ring; R2 is hydrogen, CI_IQ alkyl, C 3.7 cycloalkyl, C 3.7 cycloalkylalkyl, aryl, arylCι_ιo alkyl, heteroaryl, heteroarylCι-,10 alkyl, heterocyclic, or heterocyclylC I_IQ alkyl moiety; and wherein each of these moieties, excluding hydrogen are optionally substituted; R3 is an optionally substituted aryl ring; R4 and R14 are each independently selected from hydrogen, optionally substituted Ci-4 alkyl, optionally substituted aryl or optionally substituted aryl-Ci-4 alkyl, or R4 and R14 together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9; Rβ is hydrogen, Ci-io alkyl, C3-7 cycloalkyl, heterocyclyl, heterocyclyl Ci-ioalkyl, aryl, arylCi-io alkyl, heteroaryl or heteroarylCι_ιo alkyl; and wherein each of these moieties, excluding hydrogen, may be optionally substituted; R9 is hydrogen, C(Z)R6, optionally substituted Ci-io alkyl, optionally substituted aryl or optionally substituted aryl-Ci-4 alkyl; Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. 55. The compound according to Claim 54 wherein Ri and R3 are optionally substituted phenyl rings. 56. The compound according to Claim 55 wherein the aryl is substituted one or more times, independently, by halogen, alkyl, hydroxy, alkoxy, amino, or halosubstituted alkyl. 57. The compound according to Claim 56 wherein R3 is unsubstituted or substituted one or more times, independently with halogen. 58. The compound according to Claim 55, wherein Ri is unsubstituted or substituted one or more times, independently with halogen or alkyl. 59. The compound according to any one of Claims 54 to 58 wherein X is OR2. 60. The compound according to any one of Claims 54 to 58 wherein X is S(O) m R2- 61. The compound according to any one of Claims 54 to 58 wherein X is (CH 2 ) n NR 4 Ri4. 62. The compound according to any one of Claims 54 to 58 wherein X is (CH 2 ) n NR 2 . 63. The compound according to any one of Claims 54 to 58 wherein X is R2. 64. The compound according to Claim 54 wherein R2 is an optionally substituted alkyl, heteroaryl, or heterocyclic moiety. 65. The compound according to Claim 64 wherein R2 is an optionally substituted imidazole, pyrrolidine, piperidine, piperazine, or a morpholine ring. 66. The compound according to Claim 65 wherein the ring is substituted one or more times, independently, by halogen, Cι_ιoalkyl, halosubstituted Cι_iQalkyl, (CRι 0 R 2 o) n NR4Rl4> (CRι 0 R o)nOR6, and (CRι 0 R 2 o) n C(Z)OR 6 . 67. The compound according to any one of Claims 54 to 66 wherein the structure is of Formula (V). 68. A process for producing a compound of Formula (IN) according to Claim 1 , which process comprises reacting a compound of the formula wherein Y-Ri and R3 are as defined herein for Formula (IV); and Xι is a C ι_ιo alkyl, aryl or heteroaryl moiety; under cyclization conditions to yield a compound of the formula: wherein Y-Ri and R3 are as defined herein for Formula (IN), and X is a C ι_ιo alkyl, aryl or heteroaryl moiety; and if necessary displacing the sulfoxide or sulfone of Formula (B) with a compound of the formula: R 2 XH wherein R 2 is as is as defined for Formula (IN); and X is O/Ν/S; to yield a compound of Formula (IN). 69. The process according to Claim 68 wherein the compound of Formula (A) is produced by reacting a compound of the formula: wherein Ri and R3 are as defined in Formula (IN), and Xi is a C I_I Q alkyl, aryl or heteroaryl moiety; with a suitable reducing agent to yield a compound of Formua (A).

Inventors: ADAMS JERRY L, BOEHM JEFFREY C, HALL RALPH F, TAGGART JOHN J, ADAMS, JERRY, L., BOEHM, JEFFREY, C., HALL, RALPH, F., TAGGART, JOHN, J.
Applicants: ADAMS JERRY L, BOEHM JEFFREY C, HALL RALPH F, SMITHKLINE BEECHAM CORP, TAGGART JOHN J, ADAMS, JERRY, L., BOEHM, JEFFREY, C., HALL, RALPH, F., SMITHKLINE BEECHAM CORPORATION, TAGGART, JOHN, J.
Application year: 2001
Main classification: C07D487
IPC codes: A61K31, A61P1, A61P3, A61P7, A61P9, A61P11, A61P13, A61P17, A61P19, A61P21, A61P25, A61P27, A61P29, A61P31, A61P33, A61P35, A61P37, C07D487