Ring fluorination of non-activated aromatic compounds

Abstract: Unsubstituted aromatic compounds and aromatic compounds having one or more electron-withdrawing substituents are fluorinated, preferably in a nitromethane solvent, by contact with tri(halo- or trifluoromethyl) substituted N-fluorotriazinium salts of the following Formula I: wherein three A moieties are independently CR, where each R is independently halogen or trifluoromethyl; two A moieties are independently Z, where each Z is independently nitrogen or a quaternary nitrogen atom and Y is a counterion or group of counterions which are inert to chemical attack by fluorine. Preferably the cation of the salt is 2,4,6-trichloro-1,3,5-triazinium.

Description: This invention relates to the use of tri(halo- or trifluoromethyl) substituted N -fluorotriazinium salts to fluorinate non-activated aromatic compounds (i.e. unsubstituted aromatic compounds and aromatic compounds having one or more electron-withdrawing substituents). Fluorination is an important process in many areas of industry, in particular where the synthesis of speciality chemicals is concerned. Known fluorination methods are conveniently categorized according to the perceived manner in which the fluorinating agents provide fluorine for combination with an active site in an organic molecule, namely as fluorine atom (F - ), fluoride ion (F - ) or, conceptually, fluoronium ion (F + ). Fluorinations involving fluorine atom are notoriously exothermic and non-selective, hence "light" strategic fluorination of organic compounds (that is, the introduction of one or two fluorine substituents or a trifluoromethyl group at key molecular sites) rests on the availability of versatile ranges of nucleophilic and electrophilic sources of fluorine. Of late, the use of N -fluoro compounds has become one of the most widely used methods for the selective formation of carbon-fluorine bonds via "electrophilic" mechanisms. A recent comprehensive review of this synthetic methodology contains no reference to N-F reagents derived from triazines (see G.G. Furin in Methods of Organic Chemistry (Houben-Weyl): Volume E10a; Organofluorine Compounds (ed. B. Baasner, H. Hagemann, and J.C. Tatlow), Georg Thieme Verlag, Stuttgart, 1999, pp. 432-499. 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (so-called F-TEDA-BF 4 ) is a known, commercially available (under the trade name "Selectfluor") fluorinating agent and is useful as a general purpose fluorinating agent. However this material has only a moderate fluorinating power and is able to fluorinate benzene only under forcing conditions, for example under reflux for 24 hours. The chemistry of F-TEDA-BF 4 has been reviewed by R.E. Banks in J. Fluorine Chemistry 87 (1998) 1-17. N -Fluoropyridinium salts and ring-substituted analogues thereof, e.g. N -fluoropyridinium triflate, are known for use as a fluorinating agent but have relatively low fluorinating power. Examples of N -fluoropyridinium salts and their use as fluorinating agents are disclosed in EP-A-0204535. Example 66 of EP-A-0204535 discloses a reaction to mono-fluorinate benzene using N -fluoro-2,5-di(methoxycarbonyl)pyridinium triflate. In this example, benzene is refluxed in the presence of the pyridinium salt for 24 hours to produce fluorobenzene in a yield of 56%. US-A-4828764 discloses that certain N -fluoro- N -perfluoroalkyl or perfluoroaryl sulphonamides including, inter alia, those of the formula R 1 SO 2 NFR are electrophilic fluorinating agents. In this formula R f , represents a perfluorinated C 1 -C 30 alkyl, C 3 -C 30 cycloalkyl, C 6 -C 14 aryl substituted C 1 -C 10 alkyl or a C 6 -C 14 aryl group and R represents a C 1 -C 30 alkyl, C 3 -C 30 cycloalkyl, C 6 -C 14 aryl substituted C 1 -C 10 alkyl, or C 6 -C 14 aryl group optionally substituted with one or more inert substituents including, inter alia, fluorine and, when R f , is trifluoromethyl, R alternatively can represent perfluoromethylsulphonamido. The preferred fluorinating agents are stated to be N -fluorobis-(trifluoromethanesulphonyl)imide (R f = CF 3 and R = CF 3 SO 2 ), known as DesMarteau's Reagent, and N -fluoro- N -methyltrifluoromethanesulphonamide (R f = CF 3 and R = CH 3 ). DesMarteau's Reagent is a powerful electrophilic fluorinating agent which is capable of converting benzene to fluorobenzene at room temperature but is hazardous, time-consuming and expensive to prepare requiring eight or nine reaction steps from readily available material. Only a very limited number of other known fluorinating agents are strong enough to fluorinate benzene without forcing conditions but they often provide relatively low yields or require special precautions. Those reported to fluorinate benzene include, in addition to DesMarteau's Reagent, CF 3 OF, XeF 2 , NF 4 + BF 4 - , N 2 F + AsF 6 - , N -fluoropentachloropyridinium triflate, perfluoro-[N-fluoro-N-(4-pyridyl)methanesulphonamide] and N -fluoro-2,6-bis(methoxycarbonyl)pyridinium triflate. Very few of these compounds, only NF 4 + BF 4 - and XeF 2 , are known to fluorinate aromatic substrates having electron-withdrawing substituents such as nitrobenzene. N -Fluorotriazinium salts of the following Formula A are known: wherein: (i) X = H & Y - = AsF 6 - (Ref. 1 - see below) (ii) X = F & Y - = AsF 6 - (Ref. 2 - see below) (iii) X = F & Y - = BF 4 - (Ref. 3 - see below) and (iv) X = Cl & Y - = AsF 6 - (Refs. 2 & 4 - see below). The N -fluorotriazinium salts of Formula A are reported to be oxidising agents of use in, for example, organometallic chemistry. The cationic component of compounds of Formula A in which X is H, F and Cl have been described as "oxidative fluorinators" and a qualitative scale for their oxidising strength and that of NF 4 + has been computed ab initio (Ref. 4 - see below). Ref. 1 = Broschag et al. Inorg. Chim. Acta, 205 (1993) 167-173; Ref. 2 = Schleyer et al. Inorg. Chem. 32 (1993) 1523-1524; Ref. 3 = Schulz and Klapötke J. Organometal. Chem. 480 (1994) 195-197; and Ref. 4 = Broschag et al . Z. Anorg. Allg. Chem., 620 (1994) 1132-1136. There is a statement in Schleyer et al. that 1-fluoro-2,4,6-trichloro- s -triazinium hexafluoroarsenate (Formula A; X = Cl; and Y - = AsF 6 - ) "is a promising fluorination agent" but no further details were provided or subsequently reported. It is believed that uses of the compounds of Formula A other than as oxidising agents was not contemplated or investigated. In particular, there is no disclosure in the prior art of any of these compounds being evaluated as oxidative fluorinators (as distinct from non-fluorinating oxidising agents) despite the computed values reported in Refs. 3 and 4. We have now surprisingly found that tri(halo- or trifluoromethyl) substituted N -fluorinated triazinium salts are sufficiently strong electrophilic fluorinating agents that they will readily fluorinate non-activated aromatic compounds. In its broadest aspect, the present invention provides a method of fluorinating a substrate selected from unsubstituted aromatic compounds and aromatic compounds having one or more electron-withdrawing substituents which comprises contacting the substrate with a tri(halo- or trifluoromethyl) substituted N -fluorotriazinium salt. The N -fluorotriazinium salts are of the following Formula I: wherein: three A moieties are independently CR, where each R is independently halogen or trifluoromethyl; two A moieties are nitrogen; and Y - is a counterion or group of counterions which are inert to chemical attack by fluorine. It is presently preferred that the triazinium compounds are 1,2,4-triazinium compounds of the following Formula IA or, especially, 1,3,5-triazinium compounds of the following Formula IB: wherein: R 1 , R 2 and R 3 are independently halogen or trifluoromethyl; Z 1 and Z 2 are nitrogen; and Y - is a counterion or group of counterions which are inert to chemical attack by fluorine. As mentioned above, the N -fluoro-triazinium salts of Formula I are remarkably strong fluorinating agents capable of room temperature fluorination of unsubstituted aromatic substrates such as benzene and aromatic substrates having one or more electron-withdrawing substituents such as chlorobenzene or nitrobenzene. Usually, all R substituents, or R 1 , R 2 and R 3 for Formulae IA and IB, are identical in a given compound. The compounds of Formula I contain one fluorinated quaternary nitrogen atom in the triazinium ring. Both Z 1 and Z 2 for Formulae IA and IB, are nitrogen and the most preferred compounds are those of the following Formula II: wherein R 1 , R 2 , R 3 and Y - are as defined above. Examples of preferred compounds according to the invention are those having a triazinium cation as shown below in Formulae III to V. The counterion Y - is resistant to chemical attack by fluorine and desirably, is thermally stable and possesses low environmental toxicity. The counterion(s) can be any anion(s) which can be counterion(s) to the triazinium cation. The counterion(s) may have a single charge or a multiple charge or be a group of counterions so as to balance the charge of the triazinium moiety. Also the counterion may be a counterion to more than one mole of the triazinium cation, for example where the cation has a single charge and the counterion has a multiple charge. Suitably the counterion is weakly nucleophilic. Suitable anions include fluoride; fluorosulphate (SO 3 F - ); alkanesulphonate, especially methanesulphonate (CH 3 SO 3 - ); alkyl sulphate, especially methyl sulphate (CH 3 SO 4 - ); perfluoroalkanesulphonate, preferably triflate (CF 3 SO 3 - ) and nonaflate (C 4 F 9 SO 3 - ); arenesulphonate, especially tosylate (i.e. p -toluenesulphonate; p -CH 3 C 6 H 4 SO 3 - ); alkanecarboxylate; perfluoroalkanecarboxylate; tetrafluoroborate (BF 4 - ); tetraphenylborate (Ph 4 B - ); hexafluorophosphate (PF 6 - ); hexafluoroantimonate (SbF 6 - ); hexafluoroarsenate (AsF 6 - ); chlorate (ClO 3 - ); sulphate (SO 4 2- ) = 2Y - ); hydrogen sulphate (HSO 4 - ) and F(HF) x - where x is at least 1. Presently preferred counterions include fluoride, tetrafluoroborate, triflate, tosylate, hexafluoroarsenate and hexafluorophosphate. Preferably, the compounds of Formula I are prepared using a solvent-based process which comprises contacting a triazine compound with a fluorine source under acidic conditions in a solvent which is inert under the process conditions. Suitably the fluorine source is an electrophilic fluorine source such as, for example, fluorine gas or a mixture of fluorine gas and a neutral compound derivable from a fluorine-containing counterion Y - by removing at least one fluoride ion from Y - , for example boron trifluoride. Preferably, the fluorine source is fluorine gas. While the fluorine gas may be used without dilution, in general, it is preferable to use fluorine gas diluted with an inert gas so that the volume of the inert gas is between 99.9% and 50% for controlling the vigorous reaction. Suitable inert gases include nitrogen, helium and argon. The triazine compound to be fluorinated is suitably a compound of the Formula VI and may be obtained by subjecting a compound or a mixture of compounds of formula RCN to a known process for producing a triazine compound of formula (RCN) 3, wherein R is independently R 1 , R 2 or R 3 as described herein: The fluorination process is carried out in the presence of an acid which may be a Brønsted acid (organic or mineral) or a Lewis acid. The level of acid is suitably adjusted so as to reduce and desirably avoid double protonation of the triazine compound and to provide a yield (as determined by 19 F NMR) of F-N + of at least 20% and desirably of at least 50%. Desirably the molar ratio of acid to triazine substrate is 0.5 to 2.5, preferably 1 to 2.2. Preferable examples of Brønsted acid have pKa in the range from 12.4 to 4.6 and include halogenated alcohols, for example chlorodifluoroethanol, dichlorofluoroethanol, chlorooctafluoro-t-butanol, trifluoroethanol, tetrafluoropropanol, pentafluoropropanol, hexafluoroisopropanol, octafluoropentanol, and nonafluoro-t-butanol. Fluorinated alcohols, particularly those which are free of chlorine, are especially preferred. Other acids which are especially preferred include acids of the counterion Y - described above, for example anhydrous hydrofluoric acid, hexafluoroantimonic acid, tetrafluoroboric acid and triflic acid, sulphuric acid, methanesulphonic acid, acetic acid and trifluoroacetic acid. Brønsted acids may be used in the form of a complex with, for example, ethers, water, alcohols, nitriles, or carboxylic acids and may be used in the form of an aqueous solution. Preferably, the solvent is non-aqueous and it is presently particularly preferred that the solvent is acetonitrile, a halogenated, especially fluorinated, alcohol or, especially, nitromethane. In this connection, it is believed that there has not been any previous proposal to use nitromethane as a solvent, or for any other purpose, with any N-F or + N-F reagent. If desired the same material may be used as both the acid and the solvent. The reaction to produce a compound of Formula I is carried out at a temperature at which the solvent is in the liquid phase and suitably at a sufficiently low temperature that reaction due to a free radical mechanism is reduced and suitably avoided. The particular temperature selected depends on the solvent and also the reactants. By way of example only, the reaction suitably may be carried out at a temperature of -40 to 10 °C. A temperature of -40 to -20 °C is preferred for acetonitrile and a temperature of -10 to 5 °C is preferred for hexafluoroisopropyl alcohol. The reaction may be carried out at elevated pressure although this is not essential. Fluorination of the triazine compound may be carried out using a stirred-tank batch reactor. Where the fluorine source is gaseous, the fluorine source is suitably admitted either as neat gas at sub-atmospheric pressure or as a continuous flow of fluorine blended with nitrogen or other inert diluent at about atmospheric pressure. Advantageously, the process for producing compound of Formula I may be operated as a continuous process. The compounds of Formula I may be used as electrophilic fluorinating agents in a similar manner to Selectfluor™ and in manner know in the art (see, for example, R.E. Banks et al . J. Chem. Soc. Perkin Trans. I, 1996, 2069). The fluorinating agent may be contacted with the substrate neat and optionally at elevated temperature. If desired the fluorination process may be carried out in a solvent, for example acetonitrile or, especially, nitromethane. As mentioned above, it is believed that there has not been any previous proposal to use nitromethane as a solvent, or for any other purpose, with any N-F or + N-F reagent. When a compound of Formula I has been used in a fluorination reaction and so depleted in fluorine, it may be recovered and regenerated by introducing the fluorine source for reuse in further fluorination reactions. Compounds of Formula I may be isolated or used without separation from the reaction mixture. If desired, the reaction mixture may be fed to a separate fluorination reactor or the compound of Formula I may be purified or otherwise treated prior to use. The invention is illustrated by the following non-limiting Examples. Example 1 Preparation of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium triflate Cyanuric chloride (0.1 g, 0.54 mmol), triflic acid (0.08 g, 0.53 mmol) and acetonitrile (80 cm 3 ) were placed in the flow fluorination reactor, cooled to -35 °C, stirred vigorously and treated with a 1:9 (v/v) fluorine-nitrogen blend (flow rate of 130 cm 3 per minute) until the exit gas gave a strong positive test (Kl) for fluorine. A small sample (20 cm 3 ) of the resulting colourless reaction solution was tested for oxidation properties with aqueous Kl and gave a strong positive result. A sample (20 cm 3 ) of the cold (-35 °C) reaction solution was treated with dry benzene (2.0 cm 3 ) and the homogeneous mixture left to warm to room temperature before being analysed by 19 F NMR, using D 2 O as an external lock. The spectrum showed the characteristic absorption for fluorobenzene at δ F -36.2 (m) ppm (TFA (trifluoroacetic acid) ref.). The remaining reaction solution was evaporated under reduced pressure, yielding a white solid which fumed in air. The 19 F NMR spectrum of this fuming solid (dissolved in CD 3 CN) was found to contain the expected OTf - absorption at 5.4(s) ppm (TFA ref.), as well as an absorption at 39.3 (br. s) ppm assignable to the + NF function of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium triflate. Owing to the highly hygroscopic nature of this white solid, a satisfactory elemental analysis was impossible to obtain; iodometric titration of a sample of this product revealed that the F + content was 62% (i.e. the percentage of oxidising F + present per mole of the reagent). The reaction was repeated using hexafluoroisopropanol as the fluorination solvent, but the material obtained was only 86% pure (estimated by 19 F NMR). Example 2 Fluorinations using 1-fluoro-2.4.6 - trichloro-1.3.5-triazinium tetrafluoroborate in CD 3 CN The required amount of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate was weighed into a glass vial in an efficient dry box (argon atmosphere) before it was added to a cold solution (0 °C) of the substrate in CD 3 CN. The reaction mixture was allowed to warm to room temperature, transferred to a standard NMR tube and its spectrum measured. 1) Reaction with methoxybenzene The reaction was carried out on both a 1:1 and 2:1 molar ratio basis (methoxybenzene: + NF). In both experiments the reaction was immediate and exothermic, and the solution's changed colour from yellow (at 0 °C) to dark violet at room temperature). After 8 hours, the 19 F NMR spectra (188.8 MHz; 27 °C; CFCl 3 ) of the reaction solutions showed absorptions at δ F (1:1 reaction) -126.6 (m, 4-F) and -137.8 (m, 2-F) and (1:2 reaction) -126.6 (m, 4-F) and -137.9 (m, 2-F) ppm (product ratio: 4-F:2-F, 2:1); other (unidentified) absorptions were observed at δ F -123.2, -123.3, -132.0, and -132.9 ppm. 2) Reaction with benzene The reaction was carried out using a 1:1 molar ratio of reactants. A progressive colour change of the reaction solution was observed [colourless (0 °C to room temperature, 1.0 hour), pale yellow (room temperature, 2.0 to 4.0 hours), yellow to pale brown (room temperature, 4.0 to 8.0 hrs)], and after 8.0 hours the 19 F NMR (CFCl 3 ) spectrum was measured and found to contain only the characteristic absorption for fluorobenzene at δ F -115.2 (m) ppm and a BF 4 - peak. 3) Reaction with chlorobenzene The reaction was carried out on a 1:1 molar ratio basis. After 8.0 hours (room temperature; change from colourless to pale brown solution) the 19 F NMR (CFCl 3 ) spectrum was measured and showed an absorption at δ F -116.0 (m, 4-F) ppm assignable to 4-chlorofluorobenzene. 4) Reaction with nitrobenzene The reaction was carried out on a 1:1 molar ratio basis. After 8.0 hours (room temperature; colourless solution changed to pale brown), the 19 F NMR (CFCI3) spectrum of the product was measured and showed an absorption at δ F -109.4 (m, 3-F) which was more intense than an absorption associated with decomposition of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate (see below) and hence indicated that 3-fluoronitrobenzene had been formed. 5) 19 F NMR examination of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate in CD 3 CN A solution of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate in CD 3 CN was made at room temperature (colourless) and its 19 F NMR (ref. CFCl 3 ) spectrum was measured immediately; this showed absorptions at +15.3 (br.s., + NF) ppm and -146.7 (br.s., BF 4 - ) ppm. A number of minor peaks were observed in the region between δ F -1.0 and -110 ppm, suggesting that a decomposition of the + NF salt was taking place. The sample was left standing for 2.0 hours (the solution's colour changed to pale yellow) before the spectrum was measured again; this revealed that the intensity of + NF absorption at δ F +15.3 had markedly decreased, while the intensities of the absorption peaks associated with decomposition of the salt (δ F -1.0 to -110 ppm) had noticeably increased. These minor absorptions were present in the spectra of all of the products from the above reactions. Example 3 Fluorinations using 1-fluoro-2.4.6-trichloro-1 .3.5-triazinium tetrafluoroborate without solvent A suspension of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate (0.1 g, 3.4 mmol) and an excess of the substrate was prepared in a sealed tube at room temperature (using an argon-filled dry box). The mixture was heated to about 60 °C for a few minutes, then cooled to room temperature, before a small sample was syringed out and filtered to remove any insoluble materials (i.e. 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate) before its 19 F NMR (CFCl 3 ) spectrum was measured using D 2 O as an external lock. 1) Reaction with benzene The 19 F NMR spectrum of the product was measured immediately and showed the characteristic absorptions for monofluorobenzene at δ F -113.3(m) ppm and 1,4-difluorobenzene at δ F -119.9 ppm, with a ratio of approximately 2:1. A Kl test of the reaction mixture gave a strong positive result, indicating that the reaction had not gone to completion at this stage, and the reaction mixture was left standing at room temperature for 14 days (an excessive period, negative Kl test at this stage). The 19 F NMR spectrum of the sample was then measured again and revealed the presence of another difluoro-isomer, namely 1,2-difluorobenzene [δ F -138.7 (m) ppm; the ratio of 1,4- to 1,2-C 6 H 4 F 2 was about 2:1]. 2) Reaction with chlorobenzene The 19F NMR spectrum of the product was measured shortly after the reaction had been carried out and found to contain absorptions at δ F -111.0 (m, 3-F); -115.7 (m, 2-F) and -116.1 (m, 4-F) (the ratio of 2-:3-:4-isomers was about 1:0.3:2). After 14 days (negative Kl test), the 19 F NMR spectrum showed no evidence for the presence of any other products. 3) Reaction with nitrobenzene The 19 F NMR spectrum of the reaction solution contained one weak absorption assignable to 3-fluoronitrobenzene at δ F -110.27 (m) after about 25 minutes. After 14 days (positive Kl test still) however, the 19 F NMR spectrum showed absorptions corresponding to 3-fluoronitrobenzene at δ F -110.3 (m) and 2-fluoronitrobenzene at δ F -119.1 (m) (ratio about 2:1); also, in keeping with the result of the Kl test, the + NF absorption of the reagent was still present. A homogeneous reaction mixture was obtained in this experiment, whereas in the aforementioned fluorinations of benzene and chlorobenzene, the reaction mixtures contained suspended [(CICN) 3 F] + BF 4 - . In order to drive the fluorination of nitrobenzene to completion, the reaction mixture was heated at 90 °C for 2 hours before it was tested with Kl solution and gave a negative result. G.C. analysis revealed the presence of only 3-fluoronitrobenzene and 2-fluoronitrobenzene with no marked change in ratio (about 2:1 ratio). Despite the presence of the 2-fluoro derivative, no evidence were obtained for the presence of 4-fluoronitrobenzene. The absence of 4-fluoronitrobenzene may have resulted from loss of this isomer during the reaction or subsequent handling operations via nucleophilic displacement of the highly mobile fluorine. In this connection, the reaction vessel became etched during the reaction. Example 4 (i) Preparation of 1-fluoro-2,4.6-tris(trifluoromethyl)-1,3,5-triazinium triflate 2,4,6-Tris(trifluoromethyl)-1,3,5-triazine (0.2 g, 0.7 mmol), triflic acid (0.11 g, 0.73 mmol) and hexafluoroisopropanol (80 cm 3 ) were placed in a flow fluorination reactor, cooled (-5°C), stirred vigorously and treated with a 1:9 (vol./vol.) fluorine-nitrogen blend (flow rate of 130 cm 3 per minute) until the exit gas gave a strong positive test (Kl) for fluorine. A small sample (10 cm 3 ) of the resultant colourless reaction solution was tested for oxidation properties with aqueous Kl and gave a strong positive test. The remaining reaction solution was evaporated under reduced pressure, yielding a colourless oily material, which fumed when exposed to air. The 19 F NMR spectrum of this material (in CD 3 CN) contained the expected OTf - and CF 3 at δ F + 0.5 -6.0 (s; TFA ref.) ppm as well as a weak absorption at + 28.3 (br. s) assignable to the + NF function of 1-fluoro-2,4,6-tris(trifluoromethyl)-1,3,5-triazinium triflate. The reaction was repeated a number of times, but no pure + NF salt was isolated, believed to be due to the hygroscopic nature of + NF salt and its reactivity towards water. (ii) Fluorination of benzene with 1-fluoro-2,4.6-tris(trifluoromethyl)-1,3,5-triazinium triflate A sample (30 cm 3 ) of the cold (-5°C) reaction solution from (i) above was treated with dry benzene (2.0 cm 3 ) and the homogeneous mixture left to warm to room temperature overnight before being analysed by 19 F NMR, using D 2 O as an external lock. The spectrum showed the characteristic absorption for fluorobenzene at δ F -36.4 (m; TFA ref.) ppm. Example 5 Fluorinations using 1-fluoro-2.4.6-trichloro-1.3.5-triazinium tetrafluoroborate in nitromethane A solution of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate (0.1 g, 3.4 mmol) and the substrate in equimolar proportion was prepared in nitromethane (20 cm 3 ) in a sealed tube at room temperature (except for the reaction involving methoxybenzene), using an argon-filled dry box. Reaction progress was determined by removing small samples via a syringe and subjecting them to 19 F NMR analysis (CFCl 3 ref.; D 2 O ext. lock). 1) Reaction with methoxybenzene The reaction was carried out on both a 1:1 and 2:1 molar ratio basis (methoxybenzene: + NF). In both experiments the reaction was immediate and exothermic, and the solutions changed colour from colourless (at about -20 °C) to dark violet (at room temperature). After 2.0 hours (-ve Kl test), the 19 F NMR spectra (188.8 MHz; 27 °C, CFCl 3 ) of the reaction solutions showed absorptions at δ F (1:1 reaction) -126.6 (m, 4-F) and -137.8 (m, 2-F), and (1:2 reaction) -126.6 (m, 4-F) and -137.9 (m, 2-F) ppm (product ratio: 4-F:2-F = 2:1). 2) Reaction with benzene The 19 F NMR spectrum of the product was measured immediately and showed the characteristic absorptions for monofluorobenzene at δ F -113.3 (m) ppm and 1,4-difluorobenzene at δ F -119.9 ppm, with a ratio of approximately 2:1. A Kl test on the reaction mixture gave a strong positive result, indicating that the reaction had not gone to completion at this stage, hence, the reaction mixture was heated to 70 °C and its 19 F NMR spectrum measured at intervals to determine the progress of reaction. After 2.0 hours, the spectrum showed only absorptions for fluorobenzene and 1,4-difluorobenzene and the reaction mixture still gave a positive Kl test. However, after 6.0 hours a negative Kl test was obtained, indicating that consumption of the NF reagent was complete, and 19 F NMR analysis revealed the presence of another difluorinated isomer, namely 1,2-difluorobenzene [δ F -138.7 (m) ppm; the ratio of 1,4- to 1,2-C 6 H 4 F 2 was about 2:1]. 3) Reaction with chlorobenzene The 19 F NMR spectrum of the reaction solution was measured shortly after it had been prepared and found to contain absorptions at δ F -111.0 (m, 3-F); -115.7 (m, 2-F) and -116.1 (m, 4-F) (the ratio of 2- : 3- : 4-isomers was about 1:0.3:2). After heating the solution at 70 °C for 6.0 hours (negative Kl test), its 19 F NMR spectrum showed no evidence for the presence of any other products. 4) Reaction with nitrobenzene The 19 F NMR spectrum of the reaction solution contained one weak absorption assignable to 3-fluoronitrobenzene at δ F -110.27 (m) after about 25 minutes. After 6.0 hours of heating at 70 °C (positive Kl test still) however, the 19 F NMR spectrum showed absorptions corresponding to 3-fluoronitrobenzene at δ F -110.3 (m) and 2-fluoronitrobenzene at δ F -119.1 (m) (ratio about 2:1); also, in keeping with the result of a Kl test (weakly positive), the + NF absorption of the reagent was still present. Example 6 Preparation of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium triflate in nitromethane Cyanuric chloride (0.1 g, 0.54 mmol), triflic acid (0.08 g, 0.53 mmol) and nitromethane (80 cm 3 ) were placed in a flow fluorination reactor, cooled (about -30 °C), stirred vigorously and treated with a 1:9 (v/v) fluorine-nitrogen blend (flow-rate 130 cm 3 per minute) until the exit gas gave a strong positive test (Kl) for fluorine. A small sample (20 cm 3 ) of the resulting colourless reaction solution was tested for oxidation properties with aqueous Kl and gave a strong positive result. A sample (20 cm 3 ) of the cold (about -30 °C) reaction solution was treated with dry benzene (2.0 cm 3 ) and the homogeneous mixture left to warm to room temperature before being analysed by 19 F NMR, using D 2 O as an external lock. The spectrum showed the characteristic absorption for fluorobenzene at δ F -36.2 (m) ppm (TFA ref.). The remaining reaction solution was allowed to warm to room temperature (it remained clear and colourless) then evaporated under reduced pressure, yielding an off-white solid which fumed profusely in air. The 19 F NMR spectrum of this fuming solid (dissolved in CH 3 NO 2 and using D 2 O as an external lock) was found to contain the expected OTf - absorption at 5.4 (s) ppm (TFA ref.), as well as an absorption at 39.3 (br. s) ppm assignable to the + NF function of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium triflate. Owing to the highly hygroscopic nature of this white solid, no further analysis was obtained. The above reaction was repeated using CH 3 NO 2 diluted with CHCl 3 (mixtures containing 10%, 50% and 80% of CH 3 NO 2 were studied) as a solvent. Fluorination proceeded more cleanly as the proportion of nitromethane increased; thus, while use of neat CH 3 NO 2 or 80% CH 3 NO 2 produced clean, colourless reaction solutions at room temperature, use of the lower concentrations of CH 3 NO 2 gave coloured solutions (dark brown at 10% concentration; pale yellow at 50%), again after the reaction solutions had warmed to ambient temperature.

Claims: A method of fluorinating a substrate selected from unsubstituted aromatic compounds and aromatic compounds having one or more electron-withdrawing substituents which comprises contacting the substrate with a tri(halo- or trifluoromethyl) substituted N -fluorotriazinium salt of the following Formula I: wherein: three A moieties are independently CR, where each R is independently halogen or trifluoromethyl; two A moieties are nitrogen; and Y - is a counterion or group of counterions which are inert to chemical attack by fluorine. A method according to Claim 1, wherein the N -fluorotriazinium salt is a N -fluoro-1,2,4-triazinium compound of the following Formula IA: wherein: R 1 , R 2 and R 3 are independently halogen or trifluoromethyl; Z 1 and Z 2 are nitrogen; and Y - is a counterion or group of counterions which are inert to chemical attack by fluorine. A method according to Claim 1, wherein the N -fluorotriazinium salt is a N -fluoro-1,3,5-triazinium compound of the following Formula IB: wherein: R 1 , R 2 and R 3 are independently halogen or trifluoromethyl; Z 1 and Z 2 are nitrogen; and Y - is a counterion or group of counterions which are inert to chemical attack by fluorine. A method according to any one of the preceding claims, wherein the R substituents, or R 1 , R 2 and R 3 , are selected from chlorine, fluorine and trifluoromethyl. A method according to Claim 4, wherein the aromatic substrate is selected from chlorobenzene and nitrobenzene. A method according to any one of the preceding claims, wherein the R substituents, or R 1 , R 2 and R 3 , are identical. A method according to Claim 6, wherein each R, or each of R 1 , R 2 and R 3 , is chlorine. A method according to Claim 6, wherein each R, or each of R 1 , R 2 and R 3 , is fluorine. A method according to Claim 6, wherein each R, or each of R 1 , R 2 and R 3 , is trifluoromethyl. A method according to any of Claims 1 to 9, wherein the N -fluorotriazinium salt is a N -fluoro-1,3,5-triazinium compound of the following, Formula II: wherein R 1 , R 2 , R 3 and Y - are as defined in the relevant claim. A method according to Claim 10, wherein the N -fluorotriazinium salt is a N -fluoro-2,4,6-trichloro-1 ,3,5-triainium compound of the following Formula IIA: wherein Y - is a counterion or group of counterions which are inert to chemical attack by fluorine. A method according to Claim 10, wherein the N -fluorotriazinium salt is a N -fluoro-2,4,6-trifluoro-1,3,5-triazinium compound of the following Formula IIB: wherein Y - is a counterion or group of counterions which are inert to chemical attack by fluorine. A method according to Claim 10, wherein the N -fluorotriazinium salt is a N -fluoro-2,4,6-tris(trifluoromethyl)-1,3,5-triazinium compound of the following Formula IIC: wherein Y - is a counterion or group of counterions which are inert to chemical attack by fluorine. A method according to any one of the preceding claims, wherein Y - is selected from fluoride, fluorosulphate, alkanesulphonate, alkyl sulphate, perfluoroalkanesulphonate, arenesulphonate, alkanecarboxylate, perfluoroalkanecarboxylate, tetrafluoroborate, tetraphenylborate, hexafluorophosphate, hexafluoroantimonate, hexafluoroarsenate, chlorate, sulphate (= 2Y - ), hydrogen sulphate and F(HF) x - where x is at least 1. A method according to Claim 14, wherein Y - is selected from fluoride, tetrafluoroborate, triflate, tosylate, hexafluoroarsenate and hexafluorophosphate. A method according to Claim 15, wherein Y - is triflate.

Inventors: BANKS RONALD ERIC, BESHEESH MOHAMED KHALIFA, BANKS, RONALD ERIC, BESHEESH, MOHAMED KHALIFA
Applicants: AIR PROD & CHEM, AIR PRODUCTS AND CHEMICALS, INC.
Application year: 2001
Main classification: C07B39
IPC codes: C07C205, C07C25, C07B39, C07C17, C07D251, C07C41, C07C43, C07C201