sHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES BEARING BOTH LIPOPHILIC AND IONISABLE MOIETIES AS INHIBITORS OF PROTEIN JUNKINASES

Abstract: The present invention is related to sulfonamide derivatives having a lipophilic moiety and which are substantially soluble. Said compounds are notably for use as pharmaceutically active compounds. The present invention also related to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation. The compounds of formula (I) according to the present invention being suitable pharmaceutical agents are those wherein Ar1 and Ar2 are independently from each other substituted or unsubstituted aryl or heteroaryl groups,X is O or S, preferably O;R1 is hydrogen or a C1-C6-alkyl group, or R1 forms a substituted or unsubstituted 5-6-membered saturated or unsaturated ring with Ar1;n is an integer from 0 to 5, preferably between 1-3 and most preferred 1;Y within formula (I) is an unsubstituted or a substituted 4-12-membered saturated cyclic or bicyclic alkyl which is substituted with at least one ionisable moiety to which a lipophilic chain is attached and which is containing at least one nitrogen atom, whereby one nitrogen atom within said ring is forming a bond with the sulfonyl group of formula (I) thus providing a sulfonamide.

Description: Pharmaceutically Active Sulfonamide Derivatives Bearing Both Lipophilic and Ionisable Moieties as Inhibitors of Protein JunKinases Field of the invention The present invention is related to sulfonamide derivatives having a lipophilic moiety and which are substantially soluble. Said sulfonamide derivatives are notably for use as pharmaceutically active compounds. Also, the present invention is related to pharmaceutical formulations containing such sulfonamide derivatives. In particular, the present invention is related to sulfonamide derivatives that are useful in the treatment and/or prevention of disorders of the immune and the neuronal system. Specifically, the sulfonamide derivatives of the present invention display a substantial modulatory, notably an inhibitory activity of the JNK (Jun-Kinase) function or pathways respectively. Background of the invention Apoptosis denotes the complex contortions of the membrane and organelles of a cell as it undergoes the process of programmed cell death. During said process, the cell activates an intrinsic suicide program and systematically destroys itself. The following series of events can be observed: • The cell surface begins to bleb and expresses pro-phagocytic signals. The whole apoptotic cell then fragments into membrane-bound vesicles that are rapidly and neatly disposed of by phagocytosis, so that there is minimal damage to the surrounding tissue. • The cell then separates from its neighbors. The nucleus also goes through a characteristic pattern of morphological changes as it commits genetic suicide, the chromatin condenses and is specifically cleaved to frag- ments of DNA. Neuronal cell death plays an important role in ensuring that the nervous system develops normally. It appears that the death of developing neurons depends on the size of the target that they innervate: cells with fewer synaptic partners are more likely to die than those that have formed multiple synapses. This may reflect a process, which balances the relative number of pre- to postsynaptic neurons in the developing nervous system. Although neuronal cell death was assumed to be apoptotic, it was only recently that neurons in developing rodent brain were conclusively shown to undergo apoptosis as classified by morphology and DNA fragmentation. As cell death during development is clearly not a pathological process, it makes sense that cells actually cease to exist. Neuronal death occurs via either apoptotic or necrotic processes following traumatic nerve injury or during neurodegenerative diseases. Multiple components are emerging as key players having a role in driving neuronal programmed cell death. Amongst the components leading to neuronal apoptosis are members of the S APK/JNK being a subfamily of MAP Kinases (MAPKs). Mammalian cells respond to some extracellular stimuli by activating signaling cascades which are mediated by various mitogen-activated protein kinases (MAPKs). Despite the differences in their response to upstream stimuli, the MAP kinase cascades are organized in a similar fashion, consisting of MAP kinase kinase kinases (MAPKKK or MEKK), MAP kinase kinases (MAPKK or MKK) and MAP kinases (MAPK). MAP kinases are a broad family of kinases which includes c-Jun N-Terminal kinases (JNKs), also known as "stress-activated protein kinases" (SAPKs), as well as extracellular signal regulated kinases (ERKs) and p38 MAP kinases. Each of these three MAP kinases subfamilies is involved in at least three different but parallel pathways conveying the information triggered by external stimuli. The JNK signaling pathway is activated by ex- posure of cells to environmental stress -such as chemical toxins, radiation, hypoxia and osmotic shock- as well as by treatment of cells with growth factors or pro-inflammatory cytokines -such as tumour necrosis factor alpha (TNF-α) or interleukin-1 beta (IL-lβ). Two MAP kinase kinases (known as MKKs or MAPKKs), i.e. MKK4 (known also as JNKK1) and MKK7 (known also as JNKK2), activate JNK by a dual phosphorylation of specific threonine and tyrosine residues located within a Thr-Pro-Tyr motif on the activation loop on the enzyme, in response to cytokines and stress signals. Even further upstream in the signaling cascade, MKK4 is known to be activated itself also by a MAP kinase kinase kinase, MEKKl through phosphorylation at serine and threonine residues. Once activated, JNK binds to the N-terminal region of transcription factor targets and phosphorylates the transcriptional activation domains resulting in the up-regulation of expression of various gene products, which can lead to apoptosis, inflammatory responses or oncogenic processes (1-5). MAPKs (mitogen-activated protein kinases) are serine/threonine kinases that are activated by dual phosphorylation on threonine and tyrosine residues. In mammalian cells, there are at least three separate but parallel pathways that convey information generated by extra-cellular stimuli to the MAPKs. Said pathways consist of kinase cascades leading to activation of the ERKs (extracellular regulated kinases), the JNKs (c-Jun N- terminal kinases), and the p38/CSBP kinases. While both the JNK and p38 pathways are involved in relaying stress-type extramolecular signals, the ERK pathway is primarily responsible for transducing mitogenic/differentiation signals to the cell nucleus. S APK cascades represent a sub-family of the mitogen-activating protein kinase family, that are activated by different external stimuli including DNA damage following UV irradiation, TNF-α , IL-lβ , ceramide, cellular stress, and reactive oxygen species and have distinct substrate specificities. Signal transduction via MKK4/JNK of MKK3/p38 results in the phosphorylation of inducible transcription factors, c-Jun and ATF2, which then act as either homodimers or heterodimers to initiate transcription of down-stream effectors. c-Jun is a protein that is forming homodimers and heterodimers (with e.g. c-Fos) to produce the transactivating complex AP-which is required for the activation of many genes (e.g. matrix metalloproteinases) involved in the inflammatory response. The JNKs were discovered when it was found that several different stimuli such as UN light and TΝF-α stimulated phosphorylation of c-Jun on specific serine residues in the Ν-terminus of the protein. Three distinct JΝK enzymes have been identified as products of the genes JΝK1, JΝK2 and JNK3 and ten different isoforms of JNK have been identified (3, 6, 7). JNKl and -2 are ubiquitously expressed in human tissues, whereas JNK3 is selectively expressed in the brain, heart and testes (7, 8, 9, 10). Each isoform binds to the substrates with different affinities, suggesting, in vivo, a substrate specific regulation of the signaling pathways by the different JNK isoforms. In a recent publication of Xie X et al, (Structure 1998, 6 (8); 983-991) it has been suggested that activation of stress-activated signal transduction pathways are required for neuronal apoptosis induced by NGF withdrawal in rat PC- 12 and superior cervical ganglia (SCG) sympathetic neuronal cells. Inhibition of specific kinases, namely MAP ki- nase kinase 3 (MKK3) and MAP kinase kinase 4 (MKK4), or c-Jun (part of the MKK-4 cascade) may be sufficient to block apoptosis (see also Kumagae Y et al, in Brain Res Mol Brain Res, 1999, 67(1), 10-17 and Yang DD et al in Nature, 1997, 389 (6653); 865- 870). Within a few hours of NGF deprivation in SCG neurones, c-Jun becomes highly phosphorylated and protein levels increase. Similarly in rat PC-12 cells deprived of NGF, JNK and p38 undergo sustained activation while ERKs are inhibited. Consistent with this JNK3 KO mice are resistant to excitotoxicity induced apoptosis in the hippocampus and more importantly they display greatly reduced epileptic like seizures in response to excitotoxicity as compared to normal animals (Nature 1997, 389, 865-870). More recently, it has been reported that the JNK signalling pathway is implicated in cell proliferation and could play an important role in autoimmune diseases (Immunity, 1998, 9, 575-585; Current Biology, 1999, 3, 116-125) which are mediated by T-cell activation and proliferation. Naive (precursor) CD4 + helper T (Th) cells recognise specific MHC-peptide complexes on antigen-presenting cells (APC) via the T-cell receptor (TCR) complex. In addition to the TCT-mediated signal, a co-stimulatory signal is provided at least partially by the ligation of CD28 expressed on T-cells with B7 proteins on APC. The combination of these two signals induces T-cell clonal expression. After 4-5 days of proliferation, precursor of CD4 + T cells differentiate into armed effector Th cells that mediate the functions of the immune system. During the differentia- tion process, substantial reprogramming of gene expression occurs. Two subsets of effector Th cells have been defined on the basis of their distinct cytokine secretion pattern and their immuno-modulatory effects: Thl cells produce IFNγ and LT (TNF-β), which are required for cell-mediated inflammatory reactions; Th2 cells secrete IL-4, IL-5, IL-6, IL-10 and IL-13, which mediate B cell activation and differentiation. These cells play a central role in the immune response. The JNK MAP Kinase pathway is induced in Thl but not in Th2 effector cells upon antigen stimulation. Furthermore, the differentiation of precursor CD4 + T cells into effector Thl but not Th2 cells is impaired in JNK2-deficient mice. Therefore, in recent years it has been realised that the JNK kinase pathway plays an important role in the balance of Thl and Th2 immune re- sponse through JNK2. Some transcription factors known to be JNK substrates are the Jun proteins (c-jun, JunB and Jun D), the related transcription factors ATF2 and ATFa, Ets transcription factors such as Elk-1 and Sap-1, the tumor suppressor p53 and a cell death domain protein (DENN). Activation of the JNK pathway has been documented in a number of disease processes, thus providing a rationale for targeting this pathway for drug discovery. In addition, molecular genetic approaches have validated the pathogenic role of this pathway in several diseases. For example, auto-immune and inflammatory diseases derive from the inappropriate activation of the immune system. Activated immune cells express many genes encoding inflammatory molecules, including cytokines, growth factors, cell surface receptors, cell adhesion molecules and degradative enzymes. Many of these genes are known to be regulated by the JNK pathway, through the activation of the transcription factors c-Jun and ATF-2. The inhibition of JNK activation in bacterial lipopolysaccharide-stimulated macrophages, effectively modulates the production of the key pro-inflammatory cytokine, TNFα (11). The inhibition of .JNK activation decreases the transcription factor activation responsible of the inducible expression of matrix metalloproteinases (MMPs) (12), which are known to be responsible of the promotion of cartilage and bone erosion in rheumatoid arthritis and of generalized tissue destruction in other auto-immune diseases. The JNK cascade is also activated in T cells by antigen stimulation and CD28 receptor co-stimulation (13) and regulates the production of the IL-2 promoter (14). Inappropri- ate activation of T lymphocytes initiates and perpetuates many auto-immune diseases, including asthma, inflammatory bowel syndrome and multiple sclerosis. In neurons vulnerable to damage from Alzheimer's disease and in CA1 neurons of patients with acute hypoxia (15), JNK3 protein is highly expressed. The JNK3 gene was also found to be expressed in the damaged regions of the brains of Alzheimer's patients (16). In addition, neurons from JNK3 KO mice were found to become resistant to kainic acid induced neuronal apoptosis compared to neurons from wild-type mice (8). Based on these findings, the JNK signaling pathway and especially that of JNK2 and JNK3, is thought to be implicated in apoptosis-driven neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, epilepsy and seizures, Huntington's disease, traumatic brain injuries as well as ischemic and hemorrhaging strokes. Cardiovascular diseases, such as atherosclerosis and restenosis result from defective regulation of growth of the blood vessel wall. The JNK pathway is activated by athero- genic stimuli and regulates local cytokine and growth factor production in vascular cells (17, 18) inducing pro-atherosclerotic gene (19). Ischemia alone or coupled with reperfusion in the heart, liver, kidney or brain results in cell death and scar formation, which can ultimately lead to congestive heart failure, hepatic disorders, renal failure or cerebral dysfunction. The JNK pathway is activated by ischemia and reperfusion in the heart (20), leading to the activation of JNK-responsive genes and leukcocyte-mediated tissue damage. JNK activation is also observed in kidney (21) or liver (22) following ischemia and reperfusion. The down-regulation of JNKs has been proven to improve renal function and long-term outcome during nephritic and ischemic renal failure (23). Cancer is characterized by uncontrolled growth, proliferation and migration of cells. In early lung cancer, expression of c-jun is altered and may mediate growth factor signaling in non-small cell lung cancer (24). In addition to regulating c-jun production and activity, JNK activation can regulate phosphorylation of p53, and thus can modulate cell cycle progression (25). Moreover, the role of JNK activation in HTLV-1 (human T cell leukemia virus type 1) mediated tumorgenesis (26) suggests the potential use of JNK inhibitors in cancer treatment (27). Selective inhibition of JNK activation by a naturally occuring JNK inhibitory protein, called JNK-interacting-protein-1 (JJP1), blocks cellular transformation (28). Thus, JNK inhibitors may block transformation and tumor cell growth. With the objective of inhibiting the JNK kinase pathway, WO/9849188 teaches the use of a human polypeptide, i.e. JNK-interacting protein 1 (JJ-P-1), which is a biological product and which has also been assayed for overcoming apoptosis related disorders. Although such human polypeptides have been confirmed to have an inhibitory effect onto the JNK kinase pathway, a whole variety of drawbacks are associated with their use : • Active bio-peptides or bio-proteins are only obtained by means of rather comprehensive and expensive bio-synthesis which consequently frequently renders the resulting products fairly cost-intensive. • The peptides are known to display poor membrane penetration and may not cross the blood brain membrane, • The principal drawback to the use of peptide inhibitors or antagonists is the problem of low oral bioavailability resulting from intestinal degradation. Hence, they must be administered parenterally and finally, • peptide inhibitors or antagonists are frequently viewed by the host body as in- trading material to be eliminated, thus setting off an auto-immune response. The high relevance of the JNK pathway in some widely spread diseases stresses the need to develop inhibitors, preferentially selective, of JNKs. It is therefore an objective of the present invention to provide molecules which are suitable for the treatment of a variety of diseases, in particular of neuronal or the autoim- mune system related disorders, cancer, ischemic conditions and cardiovascular diseases. It is notably an objective of the present invention to provide chemical compounds which are able to modulate, preferably to down-regulate or to inhibit the JNK (Jun kinase) pathway so to be useful in method of treating diseases which involve the JNK pathway. Moreover, it is an objective of the present invention to provide methods for preparing said chemical compounds. It is furthermore an objective of the present invention to provide a new category of pharmaceutical formulations for the treatment of diseases, in particular those mediated by the JNK function. It is finally an objective of the present invention to provide a method for the treatment and/or prevention of diseases that are caused by disorders of the autoimmune and/or the neuronal system. Description of the invention The aforementioned objectives have been met according to the independent claims. Pre- ferred embodiments are set out within the dependent claims which are incorporated herewith. The following paragraphs provide definitions of the various chemical moieties that make up the compounds according to the invention and are intended to apply uniformly throughout the specification and claims unless an otherwise expressly set out definition provides a broader definition. "CrC ό -alkyl" refers to monovalent alkyl groups having 1 to 6 carbon atoms. This term is exemplified by groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-hexyl and the like. "Aryl" refers to an unsaturated aromatic carbocyclic group of from 6 to 14 carbon atoms having a single ring (e.g. phenyl) or multiple condensed rings (e.g. naphthyl). Preferred aryl include phenyl, naphthyl, phenantrenyl and the like. " - -alkyl aryl" refers to -C ό -alkyl groups having an aryl substituent, including benzyl, phenethyl and the like. "Heteroaryl" refers to a monocyclic heteroaromatic, or a bicyclic or a tricyclic fused- ring heteroaromatic group. Particular examples of heteroaromatic groups include optionally substituted pyridyl, pyrrolyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, l,3,4-oxadiazolyl,l,3,4-triazinyl, 1,2,3-triazinyl, benzofuryl, [2,3-dihydro]benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, iso- benzothienyl, indolyl, isoindolyl, 3H-indolyl, benzimidazolyl, imidazo[l,2-a]pyridyl, benzothiazolyl, benzoxazolyl, quinolizinyl, quinazolinyl, pthalazinyl, quinoxalinyl, cinnnolinyl, napthyridinyl, pyrido[3,4-b]pyridyl, pyrido[3,2-b]pyridyl, pyrido[4,3- bjpyridyl, quinolyl, isoquinolyl, tetrazolyl, 5,6,7,8-tetrahydroquinolyl, 5,6,7, 8-tetra- hydroisoquinolyl, purinyl, pteridinyl, carbazolyl, xanthenyl or benzoquinolyl. "Ci-C 6 -alkyl heteroaryl" refers to Ci-C 6 -alkyl groups having a heteroaryl substituent, including 2-furylmethyl, 2-thienylmethyl, 2-(lH-indol-3-yl)ethyl and the like. "Alkenyl" refers to alkenyl groups preferably having from 2 to 6 carbon atoms and having at least 1 or 2 sites of alkenyl unsaturation. Preferable alkenyl groups include ethenyl (-CH=CH 2 ), n-2-propenyl (allyl, -CH 2 CH=CH 2 ) and the like. "Alkynyl" refers to alkynyl groups preferably having from 2 to 6 carbon atoms and having at least 1-2 sites of alkynyl unsaturation, preferred alkynyl groups include ethy- nyl (-C≡CH), propargyl (-CH 2 C≡CH), and the like. "Acyl" refers to the group -C(O)R where R includes "C C 6 -alkyl", "aryl", "heteroaryl", "d-Ce-alkyl aryl" or "d-C 6 -alkyl heteroaryl". "Acyloxy" refers to the group -OC(O)R where R includes "d-C 6 -alkyl", "aryl", "heteroaryl", " -Ce-alkyl aryl" or "Q-Ce-alkyl heteroaryl". "Alkoxy" refers to the group -O-R where R includes "d-C 6 -alkyl" or "aryl" or "hetero- aryl" or "Cι-C 6 -alkyl aryl" or "Cι-C 6 -alkyl heteroaryl". Preferred alkoxy groups include by way of example, methoxy, ethoxy, phenoxy and the like. "Alkoxycarbonyl" refers to the group -C(O)OR where R includes "d-C 6 -alkyl" or "aryl" or "heteroaryl" or "d-C 6 -alkyl aryl" or "Cι-C 6 -alkyl heteroaryl". "Aminocarbonyl" refers to the group -C(O)NRR' where each R, R' includes independ- ently hydrogen or d-C 6 -alkyl or aryl or heteroaryl or "d-C 6 -alkyl aryl" or "d-C 6 - alkyl heteroaryl". "Acylamino" refers to the group -NR(CO)R' where each R, R' is independently hydrogen or "d-Cβ-alkyl" or "aryl" or "heteroaryl" or "d-C 6 -alkyl aryl" or "d-Q-alkyl heteroaryl". "Halogen" refers to fluoro, chloro, bromo and iodo atoms. "Sulfonyl" refers to group "-SO -R" wherein R is selected from H, "aryl", "heteroaryl", "d-Ce-alkyl", "d-C 6 -alkyl" substituted with halogens e.g. an -SO 2 -CF 3 group, "C C 6 - alkyl aryl" or "d-C 6 -alkyl heteroaryl". "Sulfoxy" refers to a group "-S(O)-R" wherein R is selected from H, "d-C 6 -alkyl", "d-Ce-alkyl" substituted with halogens e.g. an -SO-CF 3 group, "aryl", "heteroaryl" , "d-C 6 -alkyl aryl" or "C C 6 -alkyl heteroaryl". "Thioalkoxy" refers to groups -S-R where R includes "d-C 6 -alkyl" or "aryl" or "heteroaryl" or "d-C 6 -aιkyl aryl" or "d-C 6 -alkyl heteroaryl". Preferred thioalkoxy groups include thiomethoxy, thioethoxy, and the like. "Substituted or unsubstituted" : Unless otherwise constrained by the definition of the individual substituent, the above set out groups, like "alkyl", "alkenyl", "alkynyl", "aryl" and "heteroaryl" etc. groups can optionally be substituted with from 1 to 5 substituents selected from the group consisting of "d-C 6 -alkyl", "d-Cβ-alkyl aryl", "d- C 6 -alkyl heteroaryl", "C 2 -C 6 -alkenyl", "C 2 -C 6 -alkynyl", primary, secondary or tertiary amino groups or quarter-nary ammonium moieties, "acyl", "acyloxy", "acylamino", "aminocarbonyl", "alkoxycarbonyl", "aryl", "heteroaryl", carboxyl, cyano, halogen, hy- droxy, mercapto, nitro, sulfoxy, sulfonyl, alkoxy, thioalkoxy, trihalomethyl and the like. Alternatively said substitution could also comprise situations where neighboring substituents have undergone ring closure, notably when viccinal functional substituents are involved, thus forming e.g. lactams, lactons, cyclic anhydrides, but also acetals, thio- acetals, aminals formed by ring closure for instance in an effort to obtain a protective group. "Pharmaceutically acceptable salts or complexes" refers to salts or complexes of the below-identified compounds of formula I that retain the desired biological activity. Examples of such salts include, but are not restricted to acid addition salts formed with in- organic acids (e.g. hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, and the like), and salts formed with organic acids such as acetic acid, oxalic acid, tartaric acid, succinic acid, malic acid, fumaric acid, maleic acid, ascorbic acid, benzoic acid, tannic acid, pamoic acid, alginic acid, polyglutamic acid, naphthalene sul- fonic acid, naphthalene disulfonic acid, and polygalacturonic acid. Said compounds can also be administered as pharmaceutically acceptable quaternary salts known by a person skilled in the art, which specifically include the quarternary ammonium salt of the formula -NR,R',R" + Z\ wherein R, R', R" is independently hydrogen, alkyl, or benzyl, and Z is a counterion, including chloride, bromide, iodide, -O-alkyl, toluenesulfonate, methylsulfonate, sulfonate, phosphate, or carboxylate (such as benzoate, succinate, acetate, glycolate, maleate, malate, fumarate, citrate, tartrate, ascorbate, cinnamoate, mandeloate, and diphenylacetate). "Pharmaceutically active derivative" refers to any compound that upon administration to the recipient, is capable of providing directly or indirectly, the activity disclosed herein. "Ionisable moiety" refers to functional groups, wherein its characteristic electron distribution confers to said moiety its capacity to be transformed into an ionic or ionised group, or in other words into a salt. Preferred ionisable moieties are basic groups like amines that are protonated thus yielding a salt. "Essentially soluble" means that the compounds of the present invention display a good solubility in aqueous solvents. A preferred threshold is at about 50 μg/mL solvent, more preferably of at least 100 μg/mL solvent. "Lipophilic chain" refers to groups which have a pronounced attraction to hydrophobic groups, substituents or compounds, notably to lipids or fatty compounds or moieties. They notably include optionally substituted C 4 -C 18 -alkyl groups or a substituted or unsubstituted alkyl-aryl group. "Hydrophilic group" refers to functional groups which have a pronounced attraction to hydrophilic or polar groups, substituents or compounds or fatty compounds or moieties. They notably include carboxylates, hydroxides, sulfates or sulfonates or amines or ammonium salts. "Enantiomeric excess" (ee) refers to the products that are obtained by an essentially en- antiomeric synthesis or a synthesis comprising an enantioselective step, whereby a sur- plus of one enantiomer in the order of at least about 52% ee is yielded. In the absence of an enantiomeric synthesis, racemic products are usually obtained that do however also have the inventive set out activity as JunK 2 and/or 3 inhibitors. One aspect of the present invention consists in sulfonamide derivatives according to formula I : Ar 1 and Ar 2 are independently from each other aryl or heteroaryl groups. X is O or S, preferably O. R 1 is hydrogen or a Cι-C 6 -alkyl group, preferably H, or R 1 forms a 5-6 — membered saturated or non-saturated ring with Ar 1 . n is an integer from 0 to 5, preferably between 1-3 and most preferred 1. Y within the above formula I is a 4-12-membered saturated cyclic or bicyclic alkyl containing a nitrogen, which forms a bond with the sulfonyl group of formula I. Said 4- 12-membered saturated cyclic or bicyclic alkyl is substituted with at least one ionisable moiety carrying a lipophilic chain. The above mentioned ionisable moiety within L 1 confers an improved solubility to the molecules of formula I, compared to sulfonamide compounds which do not have such moiety. Particularly potent compounds of formula I in respect of the inhibition of JNKs, in particular of JNK 2 and/or 3 are those where L 1 also comprises a lipophilic moiety. Such lipophilic groups are believed to enter into a cavity of the enzyme to be inhibited. The present invention also includes the geometrical isomers, the optically active forms, enantiomers, diastereomers of compounds according to formula I, as well as their race- mates and also pharmaceutically acceptable salts as well as the pharmaceutically active derivatives of the sulfonamide derivatives of formula I. Preferred Ar 1 and Ar 2 in formula I are those that are independently selected from the group comprising or consisting of phenyl, thienyl, furanyl, pyrrol, pyridyl, optionally substituted by substituted or unsubstituted d-C 6 -alkyl, like trihalomethyl, substituted or unsubstituted d-C 6 -alkoxy, substituted or unsubstituted C 2 -C 6 -alkenyl, substituted or unsubstituted C 2 -C 6 -alkynyl, amino, acylamino, aminocarbonyl, d-C 6 -alkoxycarbonyl, aryl, carboxyl, cyano, halo, hydroxy, nitro, sulfonyl, sulfoxy, acyloxy, d-C 6 - thioalkoxy. The most preferred Ar 1 is a substituted phenyl including halogenophenyl (e.g. 4- chlorophenyl), nitrophenyl, hydroxyphenyl, alkoxy phenyl, pyridyl, 3,4,- dihydroxyphenyl, thioxo-dihydropyridine or its tautomer, pyrazole while the most pre- ferred Ar is an unsubstituted or substituted thienyl or furanyl group. Preferably, such substituents attached to said thienyl or furanyl group are hydrophilic groups which are groups conferring a better solubility to the molecules of formula I. They include notably carboxylic groups, carboxylates, carboxamides, OH, or OH carrying alkyl groups, hydrazido carbonyl groups, sulfates or sulfonates or amines or ammonium salts. Hydrophilic substituents on Ar 2 are of particular interest in order to fur- ther improve the solubility of the molecules of formula I. Where Ar 1 is a 4-chlorophenyl, nitrophenyl, hydroxyphenyl, alkoxy phenyl, pyridyl, 3,4,-dihydroxyphenyl, thioxo-dihydropyridine or its tautomer, pyrazole group, X is preferably O, R is hydrogen, n is 1 and Ar is thienyl or furanyl. A particularly preferred embodiment of the present invention is related to the sulfon- amide derivatives, wherein Y is a pyrrolidine, an azepan or a piperidine moiety of the below formulae. In said formulae, R 6 is selected from the group comprising or consisting of hydrogen, substituted or unsubstituted d-C 6 -alkyl, substituted or unsubstituted d-C 6 -alkoxy, OH, halogen, nitro, cyano, sulfonyl, oxo (=O), sulfoxy, acyloxy, thioalkoxy and where R 6 is not hydrogen, n' is an integer from 0 to 4, preferably 1 or 2, whereby at least one of L 1 and/or L 2 is an ionisable moiety to which a lipophilic chain is attached. In a more preferred embodiment of the sulfonamide derivatives according to formula I, Y is a pyrrolidine, an azepan or a piperidine moiety as described above, wherein R 6 is H, L 2 is H, L 1 is -NR 3 R 3 ; where at least one of R 3 and R 3 is not a hydrogen, but a sub- stituent selected from the group consisting of straight or branched C -C 18 -alkyl, aryl-d- C 18 -alkyl, heteroaryl-C 2 -C 18 -alkyl, d-C 14 -alkyl substituted with a C 3 -C 12 -cycloalkyl or -bicyclo or -tricyloalkyl, and whereby said alkyl chain may contain 1-3 O or S atoms. More preferred L 1 is -NHR 3 ; where R 3 is a straight or branched C 4 -C 12 -alkyl, preferably a C 6 -C 12 -alkyl, optionally substituted with a cyclohexyl group or R 3 is a benzyl moiety. The most preferred sulfonamide derivatives according to the present invention are those wherein, wherein Y is a piperidine group and wherein L 1 is -NHR 3 ; where R 3 is a straight or branched C 6 -C 1 -alkyl, preferably a C 8 -C 12 -alkyl, or R 3 is a benzyl moiety. Specific examples of compounds of formula I include the following : 4-chloro-N-[(5-{[4-(hexylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 3-Methoxy-N-{[5-({4-[(4-trifluoromethylbenzyl)amino]piperidin-l-yl}sulfonyl)thien- 2-yl] methyl } benzamide 4-chloro-N-[(5-{[4-(l,3-thiazol-2-ylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N-[(5-{[4-(heptylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N-[(5-{[4-(pentylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N-[(5-{[4-(butylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 4-chloro-N-[(5-{[4-(dodecylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N-{[5-({4-[(2-cyclohexylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N- { [5-({ 4- [(cyclohexylmethyl)amino]piperidin- 1 -yl } sulfonyl)thien-2- yljmethyl jbenzamide 4-chloro-N-({5-[(4-{[(lR)-l-cyclohexylethyl]amino}piperidin-l-yl)sulfonyl]thien-2- yl }methyl)benzamide N-{[5-({4-[(lR,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl } -4-chlorobenzamide 4-chloro-N- { [5 -( { 4- [(2-propoxyethyl)amino] piperidin- 1 -yl } sulf onyl)thien-2- yljmethyl }benzamide N- { [5-( { 4-[( 1 -adamantylmethyl)amino]piperidin- 1 -yl } sulf onyl)thien-2-yl]methyl } -4- chlorobenzamide 4-chloro-N-{ [5-({4-[(2-pyridin-2-ylethyl)amino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl Jbenzamide 4-chloro-N- { [5-({ 4- [(2-piperidin- 1 -ylethyl)amino]piperidin- 1-yl } sulfonyl)thien-2- yljmethyl jbenzamide 4-chloro-N- { [5-({ 4- [(2-ethylhexyl)amino]piperidin- 1 -yl } sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N-({ 5-[(4-{ [3-(lH-imidazol-l-yl)propyl]amino}piperidin-l- yl)sulfonyl]thien-2-yl}methyl)benzamide 4-chloro-N- [(5- { [4-(octylamino)piperidiη- 1 -yl] sulfonyl } thien-2-yl)methyl]benzamide N-[(5-{[4-(heptylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 3-methoxy-N-[(5-{[4-(octylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 3-methoxy-N-[(5-{ [4-(pentylamino)piperidin- 1-yl] sulfonyl }thien-2- yl)methyl]benzamide N-[(5-{[4-(butylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-[(5-{[4-(dodecylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-{[5-({4-[(2-cyclohexylethyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N-({ 5-[(4-{ [(lR)-l-cyclohexylethyl]amino }piperidin-l-yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide N-{ [5-({4-[(lR,2R,4S)-bicyclo[2.2. l]hept-2-ylamino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl }-3-methoxybenzamide 3-methoxy-N-{[5-({4-[(2-propoxyethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl Jbenzamide N-{ [5-({4-[(l-adamantylmethyl)amino]piperidin-l-yl } sulfonyl)thien-2-yl]methyl }-3- methoxybenzamide N- { [5-({ 4- [(3 ,3-diethoxypropyl)amino]piperidin- 1 -yl } sulf onyl)thien-2-yl]methyl } -3- methoxybenzamide 3-methoxy-N-{ [5-({ 4-[(3-morpholin-4-ylpropyl)amino]piperidin- 1-yl } sulfonyl)thien- 2-yl]methyl }benzamide 3-methoxy-N-{[5-({4-[(2-pyridin-2-ylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl }benzamide 3-methoxy-N-{ [5-({4-[(2-piperidin-l-ylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N- { [5-({ 4- [(2-ethylhexyl)amino]piperidin- 1 -yl } sulf onyl)thien-2-yl]methyl } -3- methoxybenzamide N-({5-[(4-{[3-(lH-imidazol-l-yl)propyl]amino}piperidin-l-yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide N-[(5-{[4-(hexylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-[(5-{[4-(heptylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 3-methoxy-N-[(5-{ [4-(octylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 3-methoxy-N-[(5-{[4-(pentylamino)azepan-l-yl]sulfonyl}thien-2- yl)methyl]benzamide N-[(5-{[4-(butylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-3-methoxybenzamide N-[(5-{[4-(dodecylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-{ [5-({4-[(2-cyclohexylethyl)amino]azepan-l-yl }sulfonyl)thien-2-yl]methyl }-3- methoxybenzamide N-({ 5-[(4- { [( 1R)- 1 -cyclohexylethyl] amino } azepan- l-yl)sulf onyl]thien-2-yl }methyl)- 3 -methoxybenzamide N-{ [5-({4-[(lR,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]azepan-l-yl}sulfonyl)thien-2- yl]methyl } -3-methoxybenzamide 3-methoxy-N-{[5-({4-[(2-propoxyethyl)amino]azepan-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N- { [5-({ 4- [(cyclohexylmethyl)amino] azepan- 1 -yl } sulf onyl)thien-2-yl]methyl } -3- methoxybenzamide N- { [5-( { 4-[( 1 -adamantylmethyl)amino] azepan- 1 -yl } sulf onyl)thien-2-yl]methyl } -3- methoxybenzamide 3-methoxy-N-{ [5-({4-[(3-morpholin-4-ylpropyl)amino]azepan-l-yl } sulfonyl)thien-2- yl]methyl } benzamide 3-methoxy-N-{[5-({4-[(2-pyridin-2-ylethyl)amino]azepan-l-yl}sulfonyl)thien-2- yljmethyl }benzamide 3-methoxy-N- { [5 -( { 4- [(2-piperidin- 1 -ylethyl)amino] azepan- 1 -yl } sulf onyl)thien-2- yl]methyl jbenzamide N-{[5-({4-[(2-ethylhexyl)amino]azepan-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N-({5-[(4-{[3-(lH-imidazol-l-yl)propyl]amino}azepan-l-yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide 4-chloro-N-[(5-{ [4-(heptylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 4-chloro-N-[(5-{ [4-(octylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 4-chloro-N-[(5-{ [4-(pentylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]benzamide N- [(5 - { [4-(butylamino) azepan- 1 -yl] sulfonyl } thien-2-yl)methyl] -4-chlorobenzamide 4-chloro-N- [(5 -{ [4-(dodecylamino)azepan-l-yl]sulfonyl }thien-2- yl)methyl]benzamide 4-chloro-N-{ [5-({4-[(2-cyclohexylethyl)amino]azepan-l-yl } sulfonyl)thien-2- yl]methyl }benzamide N-{ [5-({4-[(lR,2R,4S)-bicyclo[2.2. l]hept-2-ylamino]azepan-l-yl } sulfonyl)thien-2- yl]methyl } -4-chlorobenzamide 4-chloro-N- { [5-( { 4- [(2-propoxyethyl)amino] azepan- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide 4-chloro-N- { [5 -( { 4- [(2-ethylhexyl)amino] azepan- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide 4-chloro-N- [(5- { [4-(hexylamino)azepan- 1 -yl] sulfonyl } thien-2-yl)methyl]benzamide N-[(5-{[4-(hexylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 3-methoxy-N-[(5-{[4-({2-[3-(trifluoromethyl)phenyl]ethyl}amino)piperidin-l- yl]sulfonyl}thien-2-yl)methyl]benzamide 3-methoxy-N-({5-[(4-{[2-(4-methylphenyl)ethyl]amino}piperidin-l-yl)sulfonyl]thien- 2-yl } methyl)benzamide 3 -methoxy-N-( { 5 - [(4- { [( 1 S ,2R)-2-phenylcyclopropyl] amino } piperidin- 1 - yl)sulfonyl]thien-2-yl}methyl)benzamide 3-methoxy-N-{ [5-({4-[(l-naphthylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-{ [5-({4-[(2-phenylpropyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-({ 5-[(4-{ [2-(4-hydroxyphenyl)ethyl] amino }piperidin-l-yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide 3-methoxy-N-{ [5-({4-[(3-phenylpropyl)amino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl }benzamide N- { [5-({ 4- [(2,3-dihydroxypropyl)amino]piperidin- 1 -yl } sulf onyl)thien-2-yl]methyl } - 3-methoxybenzamide N-{[5-({4-[(2-hydroxyethyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide 3-methoxy-N-[(5-{ [4-(nonylamino)piperidin- 1-yl] sulfonyl }thien-2- yl)methyl]benzamide 3-methoxy-N-[(5-{ [4-(decylamino)piperidin- 1-yl] sulfonyl }thien-2- yl)methyl]benzamide 3-methoxy-N-[(5-{[4-(ethylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide N-{ [5-({4-[(2-[l,l'-biphenyl]-4-ylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }-3-methoxybenzamide N-{ [5-({4-[([l,r-biphenyl]-3-ylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }-3-methoxybenzamide 3-methoxy-N-{ [5-({4-[(2-thien-2-ylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-[(5-{[4-({4-[(trifluoromethyl)sulfonyl]benzyl}amino)piperidin-l- yl] sulfonyl } thien-2-yl)methyl]benzamide 3-methoxy-N-{ [5-({4-[(quinolin-4-ylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{[5-({4-[([l,l -biphenyl] -4-ylmethyl)amino] - 1 -piperidinyl } sulf onyl)-2- thienyl]methyl } -3-methoxybenzamide 4-chloro-N- { [5 -( { 4- [(2- { [(trifluoromethyl)sulf onyl] amino } ethyl)amino] - 1 - piperidinyl } sulfonyl)-2-thienyl]methyl }benzamide 4-chloro-N-[(5- { [4-(propylamino)- 1 -piperidinyl] sulfonyl } -2- thienyl)methyl]benzamide 4-chloro-N-[(5-{ [4-({4-[(trifluoromethyl)sulfonyl]benzyl}amino)-l- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N- { [5-({4-[(3 ,4-dihydroxybenzyl)amino] - 1 -piperidinyl } sulf onyl)-2- thienyl] methyl }benzamide methyl [{ l-[(5-{ [(4-chlorobenzoyl)amino]methyl}-2-thienyl)sulfonyl]-4- piperidinyl } (hexyl)amino]acetate tert-butyl [{ l-[(5-{ [(4-chlorobenzoyl)amino]methyl }-2-thienyl)sulfonyl]-4- piperidinyl } (hexyl)amino] acetate [{ l-[(5-{ [(4-chlorobenzoyl)amino]methyl}-2-thienyl)sulfonyl]-4- piperidinyl } (hexyl)amino] acetic acid N-[(5-{[3-(heptylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 3 -methoxy-N-[(5- { [3 -(octylamino)pyrrolidin- 1 -yl] sulfonyl } thien-2- yl)methyl]benzamide 3-methoxy-N-[(5-{[3-(pentylamino)pyrrolidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide N-[(5-{[3-(butylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-[(5-{[3-(dodecylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N- { [5-({ 3- [(2-cyclohexylethyl)amino]pyrrolidin- 1 -yl } sulfonyl)thien-2-yl]methyl } -3- methoxybenzamide N-({ 5-[(3- { [( 1R)- 1 -cyclohexylethyl] amino } pyrrolidin- l-yl)sulf onyl]thien-2- yl }methyl)-3-methoxybenzamide N-{[5-({3-[(lR,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]pyrrolidin-l-yl}sulfonyl)thien- 2-yl]methyl }-3-methoxybenzamide 3-methoxy-N-{ [5-({3-[(2-propoxyethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{ [5-({ 3-[(cyclohexylmethyl)amino]pyrrolidin-l-yl } sulfonyl)thien-2-yl]methyl }-3- methoxybenzamide N-{[5-({3-[(l-adamantylmethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide 3-methoxy-N-{ [5-({ 3-[(3-morpholin-4-ylpropyl)amino]pyrrolidin-l- yl } sulfonyl)thien-2-yl]methyl }benzamide 3-methoxy-N-{[5-({3-[(2-pyridin-2-ylethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3 -methoxy-N- { [5 -( { 3- [(2-piperidin- 1 -ylethyl)amino]pyrrolidin- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide N-{ [5-({3-[(2-ethylhexyl)amino]ρyrrolidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N-[(5-{[3-(hexylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 4-chloro-N-[(5-{[3-(heptylamino)pyrrolidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N- [(5 - { [3-(hexylamino)pyrrolidin- 1 -yl] sulfonyl } thien-2- yl)methyl]benzamide 4-chloro-N-[(5-{ [3-(pentylamino)pyrrolidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide N-[(5-{[3-(butylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-4- chlorobenzamide 4-chloro-N-{[5-({3-[(2-cyclohexylethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{ [5-({ 3-[(lR,2R,4S)-bicyclo[2.2. l]hept-2-ylamino]pyrrolidin-l-yl } sulfonyl)thien- 2-yl]methyl } -4-chlorobenzamide 4-chloro-N-( { 5- [(3 - { [( 1 -hydroxycyclohexyl)methyl] amino } pyrrolidin- 1- yl)sulfonyl]thien-2-yl}methyl)benzamide N-{ [5-({ 3-[(l-adamantylmethyl)amino]pyrrolidin-l-yl }sulfonyl)thien-2-yl]methyl } -4- chlorobenzamide 4-chloro-N-{[5-({3-[(3-morpholin-4-ylpropyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N-{[5-({3-[(2-pyridin-2-ylethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N-{[5-({3-[(2-piperidin-l-ylethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N- { [5-( { 3- [(2-ethylhexyl)amino]pyrrolidin- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide 4-chloro-N- [(5 -{ [3-(octylamino)pyrrolidin-l-yl]sulfonyl }thien-2- yl)methyl]benz amide methyl (2S)-l-[(5-{ [(4-chlorobenzoyl)amino]methyl }-2-thienyl)sulfonyl]-4- (hexylamino)-2-pyrrolidinecarboxylate 3-methoxy-N-{ [5-({4-[(pentylamino)methyl]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{ [5-({4-[2-(butylamino)ethyl]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N- { [5-({ 4-[(4-butylanilino)methyl] - 1 -piperidinyl } sulfonyl)-2-thienyl]methyl } -3- methoxybenzamide 4-chloro-N-{ [5-({4-[hexyl(methyl)amino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N-{ [5-({4-[(cyclohexylmethyl)(hexyl)amino]piperidin-l-yl } sulfonyl)thien- 2-yl]methyl }benzamide N-{ [5-({4-[benzyl(hexyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-4- chlorobenzamide 4-chloro-N- { [5-( { 4- [hexyl(pyridin-3-ylmethyl)amino]piperidin- 1-yl } sulfonyl)thien-2- yljmethyl }benzamide 4-chloro-N-{ [5-({4-[hexyl(pyridin-4-ylmethyl)amino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N- { [5-({ 4- [hexyl(pyridin-2-ylmethyl)amino]piperidin- 1 -yl } sulfonyl)thien-2- yl] methyl }benzamide N- { [5-( { 4-[butyl(hexyl)amino]piperidin- 1 -yl } sulf onyl)thien-2-yl]methyl } -4- chlorobenzamide 4-chloro-N-{ [5-({4-[hexyl(3-phenylpropyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N-{[5-({4-[hexyl(2-phenylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{ [5-({4-[[(5-bromo-2-furyl)methyl](hexyl)amino]piperidin-l-yl } sulfonyl)thien-2- yljmethyl } -4-chlorobenzamide 3-methoxy-N-( { 5 - [(4- { methyl [4-(trifluoromethyl)benzyl] amino } - 1 - piperidinyl)sulf onyl] -2-thienyl } methyl)benzamide 4-chloro-N-{ [5-({4-[(3-chlorobenzyl)amino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-({ 5-[(4-{ [4-(trifluoromethyl)benzyl]amino }piperidin-l- yl)sulfonyl]thien-2-yl}methyl)benzamide 3-methoxy-N- { [5-({ 4-[(3-methylbenzyl)amino]piperidin- 1-yl } sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-{[5-({4-[(4-propylbenzyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3 -methoxy-N-( { 5 - [(4- { [3-(trifluoromethyl)benzyl] amino } piperidin- 1 - yl)sulfonyl]thien-2-yl } methyl)benzamide 3-methoxy-N-({5-[(4-{[4-(trifluoromethoxy)benzyl]amino}piperidin-l- yl)sulfonyl]thien-2-yl}methyl)benzamide N-({ 5-[(4-{ [4-(difluoromethoxy)benzyl]amino }piperidin-l-yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide 3-methoxy-N-{[5-({4-[(2,3,4,5,6-pentamethylbenzyl)amino]piperidin-l- yl } sulfonyl)thien-2-yl]methyl }benzamide 3-methoxy-N-{[5-({4-[(4-propoxybenzyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{ [5-({4-[(4-butoxybenzyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide 3-methoxy-N-{ [5-({4-[(4-methoxybenzyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl] methyl }benzamide 3-methoxy-N-{ [5-({4-[(pyridin-4-ylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-{ [5-({4-[(pyridin-2-ylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-{[5-({4-[(pyridin-3-ylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl }benzamide N- { [5-( { 4- [(4-tert-butylbenzyl)amino]piperidin- 1 -yl } sulfonyl)thien-2-yl]methyl } -3- methoxybenzamide N-{ [5-({4-[(3-ethoxybenzyl)amino]piperidin-l-yl }sulfonyl)thien-2-yl]methyl }-3- methoxybenzamide 3-methoxy-N-{ [5-({4-[(4-phenoxybenzyl)amino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl }benzamide 3-methoxy-N-[(5-{[4-({4-[(trifluoromethyl)sulfanyl]benzyl}amino)piperidin-l- yl]sulfonyl}thien-2-yl)methyl]benzamide 3-methoxy-N-({ 5-[(4-{ [4-(methylsulfonyl)benzyl] amino }-l-piperidinyl)sulfonyl]-2- thienyl }methyl)benzamide N-( { 5-[(4- { [3 ,5-bis(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulfonyl]-2- thienyl } methyl)-3-methoxybenzamide N-( { 5- [(4- { [2,5-bis(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulfonyl]-2- thienyl } methyl)-3 -methoxybenzamide N-({5-[(4-{[4-(ethylsulfanyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl } methyl)-3 -methoxybenzamide 3-methoxy-N-[(5- { [4-( { 3- [(trifluoromethyl)sulf anyljbenzyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide N-( { 5- [(4- { [(2,2-difluoro- 1 ,3-benzodioxol-5-yl)methyl] amino } - 1 - piperidinyl)sulfonyl]-2-thienyl}methyl)-3-methoxybenzamide N- { [5-({ 4- [(4-iodobenzyl)amino]- 1 -piperidinyl } sulfonyl)-2-thienyl]methyl } -3- methoxybenzamide N-( { 5- [(4- { [4-(benzyloxy)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2-thienyl } methyl)- 3 -methoxybenzamide N-{ [5-({4-[(mesitylmethyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide N-{ [5-({4-[(4-chlorobenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide N-{ [5-({4-[(4-ethylbenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide 3-methoxy-N- { [5-( { 4-[(4-pentylbenzyl)amino]- 1 -piperidinyl } sulfonyl)-2- thienyl]methyl jbenzamide 3-methoxy-N-[(5-{ [4-({ 1 -[4-(trifluoromethyl)phenyl] ethyl } amino)- 1- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 3-methoxy-N- { [5-( { 4-[(4-methylbenzyl)amino]- 1 -piperidinyl } sulfonyl)-2- thienyl]methyl }benzamide N- { [5-({ 4- [(4-butylbenzyl)amino] - 1 -piperidinyl } sulfonyl)-2-thienyl]methyl } -3- methoxybenzamide N-{ [5-({4-[(4-isopropylbenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide N-{[5-({4-[(4-isobutylbenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide N-( { 5- [(4- { [( 1 -hydroxy- 1 lambda~5 ~-pyridin-4-yl)methyl] amino } - 1 - piperidinyl)sulfonyl]-2-thienyl}methyl)-3-methoxybenzamide N- { [5-({ 4-[(2,3-dihydro- 1 ,4-benzodioxin-6-ylmethyl)amino] - 1 -piperidinyl } sulf onyl)- 2-thienyl]methyl } -3 -methoxybenzamide N- { [5-( { 4-[(2,3-dihydro- 1 -benzofuran-5-ylmethyl)amino]- 1 -piperidinyl } sulfonyl)-2- thienyl]methyl } -3-methoxybenzamide 4-chloro-N- { [5-( { 4- [(4-propylbenzyl)amino]- 1 -piperidinyl } sulf onyl)-2- thienyl]methyl }benzamide 4-chloro-N-({5-[(4-{[4-(trifluoromethoxy)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl }methyl)benzamide 4-chloro-N-( { 5- [(4- { [4-(difluoromethoxy)benzyl] amino } - 1 -piperidinyl)sulfonyl]-2- thienyl }methyl)benzamide 4-chloro-N- { [5 -( { 4- [(4-propoxybenzyl)amino] - 1 -piperidinyl } sulf onyl)-2- thienyl]methyl Jbenzamide N- { [5-( { 4- [(4-butoxybenzyl)amino] - 1 -piperidinyl } sulf onyl)-2-thienyl] methyl } -4- chlorobenzamide 4-chloro-N-{ [5-({4-[(4-quinolinylmethyl)amino]-l-piperidinyl}sulfonyl)-2- thienyl]methyl }benzamide N-{ [5-({4-[(4-tert-butylbenzyl)amino]-l-piperidinyl } sulf onyl)-2-thienyl] methyl }-4- chlorobenzamide 4-chloro-N- { [5 -( { 4- [(4-phenoxybenzyl)amino] - 1 -piperidinyl } sulf onyl)-2- thienyl]methyl }benzamide 4-chloro-N-[(5- { [4-( { 4-[(trifluoromethyl)sulf anyl]benzyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N-( { 5-[(4- { [4-(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulfonyl]-2- thienyl }methyl)benzamide 3-methoxy-N-({5-[(4-{[2-(trifluoromethyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl }methyl)benzamide 3-methoxy-N-[(5-{ [4-({ [6-(trifluoromethyl)-3-pyridinyl]methyl }amino)-l- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide N-[(5-{[4-(benzylamino)-l-piperidinyl]sulfonyl}-2-thienyl)methyl]-3- methoxybenzamide 3-methoxy-N-[(5-{ [4-({ l-[4-(trifluoromethyl)phenyl]propyl}amino)-l- piperidinyl] sulfonyl } -2-thienyl )methyl]benzamide 3 -methoxy-N- [(5- { [4-( { 1 -methyl- 1 - [4-(trifluoromethyl)phenyl] ethyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N-[(5-{ [4-({ l-[4-(trifluoromethyl)phenyl]ethyl}amino)-l- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N- [(5 - { [4-( { 1 -methyl- 1 - [4-(trifluoromethyl)phenyl] ethyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N- [(5- { [2-({ [4-(trifluoromethyl)benzyl]amino}methyl)-l- pyrrolidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N-[(5-{ [(3R)-3-({ [4- (trifluoromethyl)benzyl] amino } methyl)pyrrolidinyl] sulfonyl } -2- thienyl)methyl]benzamide 4-chloro-N-( { 5 - [(3 - { [4-(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulfonyl] -2- thienyl }methyl)benzamide 4-chloro-N-{[5-({3-[(hexylamino)methyl]-l-piperidinyl}sulfonyl)-2- thienyl]methyl }benzamide 4-chloro-N-({ 5- [(3- { [4-(trifluoromethyl)benzyl] amino } - 1 -pyrrolidinyl)sulfonyl] -2- thienyl }methyl)benzamide 4-chloro-N-{[5-({(3R)-3-[(hexylamino)methyl]pyrrolidinyl}sulfonyl)-2- thienyl]methyl }benzamide 4-chloro-N- [(5- { [3-({ [4-(trifluoromethyl)benzyl]amino}methyl)-l- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 2-oxo-N-({5-[(4-{[4-(trifluoromethyl)benzyl]aιnino}-l-piperidinyl)sulfonyl]-2- thienyl } methyl)- 1 ,2-dihydro-3 -pyridinecarboxamide N- [(5 - { [4-(hexylamino)- 1 -piperidinyl] sulfonyl } -2-thienyl)methyl] -2-oxo- 1 ,2-dihydro- 3 -pyridinecarboxamide N- [(5- { [4-(hexylamino)- 1 -piperidinyl] sulfonyl } -2-thienyl)methyl]-2- hydroxybenzamide 2-hydroxy-N-( { 5-[(4- { [4-(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulfonyl] -2- thienyl }methyl)benzamide N- [(5 - { [4-(hexylamino)- 1 -piperidinyl] sulfonyl } -2-thienyl)methyl] -2-thioxo- 1,2- dihydro-3-pyridinecarboxamide 2-thioxo-N-({5-[(4-{[4-(trifluoromethyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl}methyl)-l,2-dihydro-3-pyridinecarboxamide N-[(5-{[4-(butylaπ-ino)-l-piperidinyl]sulfonyl}-2-thienyl)methyl]-2-oxo-l,2-dihydro- 3-pyridinecarboxamide N-( { 5- [(4- { ethyl [4-(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2- thienyl}methyl)-3-methoxybenzamide 4-chloro-N- [(5 - { [4-( { imino [4-(trifluoromethyl)phenyl]methyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide l-[(5-{ [(4-chlorobenzoyl)amino]methyl}-2-thienyl)sulfonyl]-4-(hexylamino)proline ethyl 2-{ [4-(hexylamino)piperidin- 1-yl] sulfonyl} -5- { [(3- methoxybenzoyl)amino]methyl}thiophene-3-carboxylate N-{[5-{[4-(hexylamino)piperidin-l-yl]sulfonyl}-4-(trimethylsilyl)thien-2-yl]methyl}- 3-methoxybenzamide N-({ 5-{ [4-(hexylamino)piperidin-l-yl]sulfonyl }-4-[hydroxy(phenyl)methyl]thien-2- yl }methyl)-3 -methoxybenzamide 5-[(3-Methoxy-benzoylamino)-methyl]-2-[4-(4-trifluoromethyl-benzylamino)- piperidine-l-sulfonyl]-thiophene-3-carboxylic acid ethyl ester N-[(4-chloro-5-{[4-(hexylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide The compounds of formula I are suitable for use in treating disorders of the immune system and neuronal system of mammals, notably of human beings. Such neuronal system disorders include for example neurodegenerative diseases e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease, retinal diseases, spinal cord injury, multiple sclerosis, head trauma, epilepsy and seizures, ischemic and hemorragic brain strokes. Immune system disorders include for example asthma, transplant rejection, inflammatory processes such as inflammatory bowel disease (IBD), cartilage and bone erosion disorders, rheumatoid arthritis, septic shock. The compounds according to formula I are also suitable for use in treating cancers, such as breast, colorectal, pancreatic, prostate, testicular, ovarian, lung, liver and kidney cancers. In another embodiment, the compounds according to formula I may be used for treating cardiovascular diseases including atherosclerosis, restenosis, stroke, ischemia, e.g. cere- bral ischemia, myocordial infarction. In another embodiment, the compounds according to formula I may be used for treating various ischemic conditions including heart and kidney failures, hepatic disorders and brain reperfusion injuries. Preferably, the compounds according to formula I, alone or in the form of a pharmaceu- tical composition, are useful for the modulation of the JNK pathway, more specifically for treatment or prevention of disorders associated with expression or activity of JNK, notably of JNK2 and -3. Said modulation usually preferably involves the inhibition of the JNK pathways, notably of the JNK2 and/or -3. Such an abnormal expression or activity of JNK may be triggered by numerous stimuli (e.g. stress, septic shock, oxidative stress, cytokines) and may cause a cascade of processes, leading to, for example, uncontrolled apoptosis, inflammatory responses or oncogenic processes. These phenomena are frequently involved in various disorders including the above enumerated disorders and disease states. Hence, the compounds according to the invention may be used for the treatment of disorders by modulating the JNK function or signaling pathways. The modulation of the JNK function or pathways may involve its activation, but preferably it involves the down-regulation up to inhibition of the JNK pathways, notably of JNKl and/or -2 and/or JNK3. The compounds of the invention may be employed alone or in combination with further pharmaceutical agents, e.g. with a further JNK modulator. Still a further object of the present invention is a process for preparing the novel su- fonamide derivatives according to formula I which have been set out above. The sulfonamide derivatives of this invention may be prepared from readily available starting materials using the following general methods and procedures. It will be appreciated that where typical or preferred experimental conditions (i.e., reac- tion temperatures, time, moles of reagents, solvents, etc.) are given, other experimental conditions can also be used unless otherwise stated. Optimum reaction conditions may vary with the particular reactants or solvent used, but such conditions can be determined by one skilled in the art by routine optimisation procedures. The compounds of formula I may be obtained by either of the approaches set out in Scheme 1 or 2: Scheme 1 Ar 1 — r N— (CH 2 )— Ar 5 — SO 2 CI HN (V) (Vlll) Ar 1 - N— (CH 2 )— Ar 5 — SOj N ^L (1) Scheme 2 Thereby, Ar 1 , Ar 2 , R 1 , L and n are as above defined, P is a suitable protective group (R 1 is preferably not a hydrogen, preferably a protective group). Sulfonyl chlorides of formula (N), as used in Scheme 1, may be prepared according to a procedure set out in Scheme 3 : Scheme 3 Ar-TT-CI R 1 HΝ— (CH 2 )— Ar 2 (III) (H) (IV) (V) Thereby, Ar 1 , Ar 2 , R 1 and n are as above defined. Amines of formula II are either known compounds or may be prepared from known compounds by conventional procedures. Preferred amines as starting materials include thien-2-yl-methylamine, furan-2-yl-methylamine, pyrrolyl-2-yl-methylamine, pyridyl-2- yl-methylamine, thien-2-yl-ethylamine, furan-2-yl-ethylamine, pyridyl-2-yl-ethylamine, thien-2-yl-propylamine, furan-2-yl-propylamine, pyridyl-2-yl-propylamine and the like. The acyl chlorides of formula in are also commercially available or previously described compounds. Preferred acyl chlorides include halogenobenzoylchlorides, e.g. 4- chlorobenzoyl chloride, 4-fluorobenzoyl chloride or trifluoromethylbenzoyl chloride, alkoxybenzoylchloride, pyridylcarbonylchloride and the like. Acyl halides (HI) may also be prepared by reacting the corresponding carboxylic acid with an inorganic acid halide, such as thionyl chloride, phosphorus trichloride or oxalyl chloride under conventional conditions. Generally, such reaction is performed upon using about 1 to 5 molar equivalents of the acyl halide or oxalyl chloride, either in pure form or in an inert solvent, such as carbon tetrachlori.de, at temperature in the range of about 0°C to about 80°C for about 1 to about 48 hours. A catalyst, as N,N-dimethylform-amide, may also be used in this reaction. When an acyl halide (HI) is employed in the coupling reaction set out in Scheme 3, it is typically reacted with amine (II) in the presence of a suitable base to scavenge the acid generated during the reaction. Suitable bases include, by way of example, triethylamine, diisopropylethylamine, N-methylmorpholine and the like. Alternatively, an excess of amine II may be used to scavenge the acid generated during the reaction. Alternatively, the carboxylic acid of compound (III) can be employed in the coupling reaction. The carboxylic acids and derivatives (III) are usually commercially available reagents or can be prepared by conventional procedures. The coupling reaction of carboxylic acid of formula III (i.e. the acyl chloride) with the amine (II) is typically performed while using any conventional coupling reagent including, for example, carbodiimides such as dicyclohexylcarbodiimide, Ν-(3- dimethylaminopropyl)-N' -ethylcarbodiimide and other promoting agents, such as N,N- carbonyl-diimidazole or PyBOP. This reaction can be conducted with or without the use of well known additives such as N-hydroxysuccinimide, 1-hydroxybenzotriazole, etc. which are known to facilitate the coupling of carboxylic acids and amines. The coupling reaction using either acyl halide (III) or its carboxylic acid is preferably conducted at a temperature of from about 0°C to about 6°C for about 1 to about 24 hours. Typically, the reaction is conducted in an inert aprotic polar solvent such as Ν,Ν- dimethylformamide, dichloromethane, chloroform, acetonitrile, tetrahydrofuran and the like using about 1 to about 5 molar equivalents of the amine based on the carboxylic acid or its acid halide. Upon completion of the reaction, the carboxamide (IV) is recov- ered by conventional methods including precipitation, chromatography, filtration, distillation and the like. The sulfonyl chorides of formula V necessary for the preparation of the final products of formula I, notably those being sulfonylpiperidines or -pyrrolidines or -azepans, are prepared using conventional sulfonating methods applied on the carboxamides (IN): R 1 Ar 1 — π-N— (CH 2 )— Ar— S0 2 CI ( v ) O A preferred sulfonating reagent for use in this reaction (as set out in scheme 3) is chlo- rosulfonic acid (HSO 3 -Cl). Typically, the sulfonation reaction is performed by treating the carboxamide of formula (IV) with about 5 to about 10 molar equivalent of the sulfonating reagent in an inert solvent, such as dichloromethane, at a temperature ranging from about -70°C to about 50°C. Preferably, the addition of chlorosulfonic acid takes place at -70°C and leads to the formation of the intermediate sulfonic acid. Increasing the temperature to 20°C allows the formation of the sulfonyl chloride of formula V. Compounds of formula I with X = S are accessible from the corresponding arylamides (with X = O), e.g. benzamides, through standard functional group inter-conversion methods well known to the person skilled in the art, e.g., by treatment with Lawesson's reagent or others (Pedersen, B. S. et al.; Bull. Soc. Chim. Belg. 1978, 87, 223). An alternative approach for the preparation of compounds of formula I is set out in Scheme 2 above and involves the following steps : • Protection of the amine function of compounds of formula II; • Chlorosulfonylation of the aromatic group (Ar 2 in compounds VI), thus yielding compounds of formula VII; • Formation of the sulfonamide function (yielding compounds IX); • Removal of the protecting group P (Deprotection) within compounds IX; • Acylation of the above generated free amine to provide compounds (I); Thereby, the sulfonyl chloride precursor (VII) may be prepared by the following steps Scheme 4 Amines of formula II are protected with a suitable protecting group for an amine moiety to provide intermediate of formula VI wherein P denotes the protecting group. Numer- ous protecting groups P of the amine function as well as their introduction and removal, are well described in T.W. Greene and G.M. Wuts, Protecting groups in Organic Synthesis, Third Edition, Wiley, New York, 1998, and references cited therein. Preferred are protecting groups that are acids and bases stable and can be further removed by using metal transition complexes such as palladium complexes, for example the allylcar- bamate group (Alloc) or the N,N'-bisallyl group. Another preferred protecting group is the maleimide group which is stable in a all range of experimental conditions. The introduction of said groups may be performed by reacting the corresponding bisal- lylcarbonate anhydride or allylbromide or maleic anhydride in the presence of a base such as triethylamine, diisopropylethylamine, N-methylmorpholine and the like in an aprotic solvent such as Ν,Ν-dimethylformamide, dichloromethane, chloroform, aceto- nitrile, tetrahydrofuran and the like at a temperature ranging from about 0°C to about 80°C. Compounds of formula VI in Scheme 4 are then sulfonated using a conventional, very mild sulfonating procedure that allows the obtention of sulfonyl chloride of formula VII. Typically, protected amines VI are treated with a base such as n-butyllithium or tert-butyl-lithium under an inert atmosphere, in a polar aprotic solvent such as tetrahydrofuran, ether or dioxane at a temperature ranging from -70°C to 0°C during a time ranging from 15 minutes to 4 hours. The so formed anion is then treated with SO 2 Cl 2 or most preferably SO 2 by bubbling the gas into the reaction mixture at a temperature ranging from -70°C to 20°C during a time ranging from 5 minutes to 1 hour. The sulfi- nate obtained is then transformed "in situ" to the sulfonyl chloride of formula VII by contacting with N-chlorosuccinimide or other suitable chlorinating agents including POCl 3 , SO 2 Cl 2 , COCl 2 , at a temperature ranging from 0 ° C to 70°C. Following either of Schemes 1 and 2, the sulfonamide derivatives of formula I may be obtained by reacting sulfonyl chlorides N or Nil with a cyclic or bicyclic amine (NIII), i.e. an alkyl containing a nitrogen according to the above definition. Preferred cyclic amines (NIII) include pyrrolidine or azepan or piperidine derivatives of the general formula (VIII") or (VHP) or (VIIF"). whereby (R ) n , L and L are as above defined. The amines of formula VTH' ' ' or VIIF ' or VIIF are either commercially available com- pounds or compounds that may be prepared by known procedures. The coupling reaction of sulfonyl chlorides (V) and (VII) with the amines VIII to provide sulfonamides of formula I is performed by contacting the sulfonyl chlorides with an amine of formula VIII in the presence of a suitable base to scavenge the acid generated during the reaction. Suitable bases include, by way of examples, triethylamine, di- isopropylethylamine, Ν-methylmorpholine and the like. The reaction is preferably conducted in a solvent such as Ν,Ν-dimethylformamide, dimethylsulfoxide, N-methyl- pyrrolidone, ethanol, acetonitrile typically at a temperature from about 0° to about 100°C. According to a preferred embodiment, the sulfonamide derivatives of formula I are prepared by reacting a sulfonyl chloride V or VII, with a piperidine of formula NIII' ' ' . Piperidines of formula NIII' ' ' are either commercially available or they may be prepared by known procedures. Such conventional methods known by one skilled in the art are described by way of examples in J. Pharm. Sci. 1972, 61, 1316; J. Heterocyclic. Chem., 1986, 23, 73; Tetrahedron Lett., 1996, 37, 1297, US 5106983, WO/9113872 and WO/9606609. The piperidino sulfonamides of formula I may be prepared by contacting the sulfonyl chlorides (V) and /or (VII) with a piperidine of formula VIIF ' ' in the presence of a suit- able base to scavenge the acid generated during the reaction. Suitable bases include, by way of examples, triethylamine, diisopropylethylamine, Ν-methylmorpholine and the like. The reaction is preferably conducted in solvents such as Ν,Ν-dimethylformamide, dimethylsulfoxide, N-methylpyrrolidone, ethanol, acetonitrile at a temperature from about 0° to about 100°C. The specific sulfonamides of formula XIV - where R 1 is hydrogen - are readily prepared from the protcted sulfonyl chlorides VII, by contacting said sulfonyl chlorides VII with an amine of formula VIII in the presence of a suitable base to scavenge the acid generated during the reaction. Suitable bases include, by way of examples, triethylamine, di- isopropylethylamine, N-methylmorpholine and the like. The reaction is preferably conducted in solvents such as N,N-dimethylformamide, dimethylsulfoxide, N- methylpyrrolidone, ethanol, acetonitrile at a temperature from about 0° to about 100°C. The use of sulfonyl chloride of type VII leads to amines that have to be deprotected using well known methods by one skilled in the art to afford amine of general formula XIV R 1 HN — (CH 9 2)/ n n Ar— SO 2 ? -Y χi y wherein R 1 , Ar 2 , Y and n are as above defined. Derivatives of type XIV are then acylated according to described methods for the preparation of amides by condensation of amines with acid chlorides or carboxylic acids in the preferred conditions described above leading to compounds of general formula I A specific approach for preparing piperidino sulfonamides of formula I (Y is a piperi- 1 ^ dine VIIF "), wherein L is a moiety -NHR , involves either • the reaction of an amino-piperidine (Villa) with an aldehyde (Xa), or • the reaction of a piperidine-4-one (Vlllb) with an amine (Xb); and is specified in Scheme 5 : Scheme 5 reduction (Villa) (Xa) reduction (Vlllb) (Xb) (Vllld) R 3 , R 3 ', R 6 are as above defined, R' is H or an alkyl group, R is an aryl, preferably a phenyl group and P is a protective group. The aminated piperidines (NIIIc) and (NHId) may then be reacted with the sulfonyl chlorides V or VII to provide the sulfonamides of formula I or formula IX respectively. Carbonyl compounds (Xa) are commercially available and include unsubstituted or substituted benzaldehydes (like e.g. benzaldehyde or 4-trifluoromethylbenzaldyde, etc.), unsubstituted or substituted ketones (like e.g. acetophenone or 4-trifluoroacetophenone, etc.), unsubstituted or substituted aliphatic aldehydes or ketones (like e.g. hexanal, 2- propoxyacetaldehyde or heptane-2-one, etc.) Amines (Xb) are commercially available and include unsubstituted or substituted primary alkylamines (like e.g. hexylamine, 2-pyridine-2-ethylamine etc.), as well as unsubstituted or substituted secondary alkylamines (like, e.g. N-methylhexylamine, etc.) 4-Oxo-piperidine and azepane-4-one are commercially available. A more preferred approach for preparing sulfonamides of formula I wherein Y is a piperidine moiety (VIIIc) and (Nπid) are obtained by following Scheme 6 and 7: Scheme 6 Scheme 7 A specific approach for preparing pyrrolidine sulfonamides of formula I (i.e. where Y is a pyrrolidine NIII"), with L being a moiety -ΝHR , involves the steps of • providing a hydroxypyrrolidine (Vlllf); • subjecting said hydroxypyrrolidine (Vlllf) to an oxidation to yield the corresponding ketone (Vfflg) and • to reductively aminate the ketone (NHIg) to yield the sulfonamide (Ic) Said approach is specified in Scheme 8 : Scheme 8 : (Vlllc) oxidation The oxidative step may be performed using oxidative agents like C 2 O 2 Cl2/DMSO or Chromium(NI)derivatives or periodinane derivatives as described by Dess and Martin (40). A specific approach for preparing sulfonamides of formula I where Ar is substituted with R 6 involves the steps of: • providing the sulfonyl choride (Nil) with a protecting group P; • reacting the sulfonyl choride (VII) with an amine (VIII), e.g. a protected piperidin- 4-one thus providing a sulfonamide (IX) • subjecting said sulfonamide (IX) to a metalation of Ar (e.g. by using BuLi) to yield the corresponding substituted sulfonamide (IXa), with R 6 being a carboxylic group, carboxylate, carboxamide, OH, or OH carrying alkyl group, hydrazido carbonyl groups, sulfate or sulfonate or amine or ammonium salts, • removing protecting group P of said sulfonamide (IXa) and acylating the sulfonamide to yield compounds of formula (IXb), • deprotecting said sulfonamide (IXb) and to reductively aminate the corresponding ketone to yield compounds of formula I. Said approach is illustrated in scheme 9: Scheme 9: R' I N- -(CH 2 ) n — Ar-S- Cl (VII) HN OO If the above set out general synthetic methods are not applicable for the obtention of compounds of formula I, suitable methods of preparation known by a person skilled in the art should be used. For example, when Ar 2 is phenyl, one should start from commercially available 4-cyanophenyl sulfonyl chloride and applies conventional methods known by a person skilled in the art to reach sulfonamide derivatives of formula I. A further aspect of the present invention is related to sulfonamide compounds (XIX) in particular for use as intermediate compounds in the preparation of sulfonamides of formula (I). 1 wherein Ar and Ar are independently from each other aryl or heteroaryl, X is O or S; R 1 is hydrogen or a -C ό -alkyl group, n is an integer from 0 to 5, and Y is a pyrrolidine-3-one, a piperidine 4-one, pyrrolidine-3-amine or a piperidine 4- amine, or their ammonium salts. (XlXa) (XlXb) (XIXc) (XlXd) A final aspect of the present invention is related to the use of the compounds according to formula I for the modulation of the JNK function, or signaling pathways, the use of said compounds for the preparation of pharmaceutical compositions for the modulation of the JNK pathway as well as the formulations containing the active compounds according to formula I. Said modulation of the JNK pathway is viewed as a suitable approach of treatment for various disorders. When employed as pharmaceuticals, the sulfonamide derivatives of the present invention are typically administered in the form of a pharmaceutical composition. Hence, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable carrier, diluent or excipient therefore are also within the scope of the present invention. A person skilled in the art is aware of a whole variety of such carrier, diluent or excipient compounds suitable to formulate a pharmaceutical composition. Also, the present invention provides com- pounds for use as a medicament. In particular, the invention provides the compounds of formula I for use as JNK inhibitor, notably JNK 2 and/or 3, for the treatment of disorders of the immune as well as the neuronal system of mammals, notably of humans, either alone or in combination with other medicaments. The compounds of the invention, together with a conventionally employed adjuvant, carrier, diluent or excipient may be placed into the form of pharmaceutical compositions and unit dosages thereof, and in such form may be employed as solids, such as tablets or filled capsules, or liquids such as solutions, suspensions, emulsions, elixirs, or capsules filled with the same, all for oral use, or in the form of sterile injectable solutions for par- enteral (including subcutaneous use). Such pharmaceutical compositions and unit dos- age forms thereof may comprise ingredients in conventional proportions, with or without additional active compounds or principles, and such unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the intended daily dosage range to be employed. When employed as pharmaceuticals, the sulfonamides derivatives of this invention are typically administered in the form of a pharmaceutical composition. Such compositions can be prepared in a manner well known in the pharmaceutical art and comprise at least one active compound. Generally, the compounds of this invention are administered in a pharmaceutically effective amount. The amount of the compound actually administered will typically be determined by a physician, in the light of the relevant circumstances, including the condition to be treated, the chosen route of administration, the actual com- pound administered, the age, weight, and response of the individual patient, the severity of the patient's symptoms, and the like. The pharmaceutical compositions of these inventions can be administered by a variety of routes including oral, rectal, transdermal, subcutaneous, intravenous, intramuscular, and intranasal. Depending on the intended route of delivery, the compounds are preferably formulated as either injectable or oral compositions. The compositions for oral administration can take the form of bulk liquid solutions or suspensions, or bulk powders. More commonly, however, the compositions are presented in unit dosage forms to facilitate accurate dosing. The term "unit dosage forms" refers to physically discrete units suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical excipient. Typical unit dosage forms include prefilled, premeasured ampoules or syringes of the liquid compositions or pills, tablets, capsules or the like in the case of solid compositions. In such composi- tions, the sulfonamide compound is usually a minor component (from about 0.1 to about 50% by weight or preferably from about 1 to about 40% by weight) with the remainder being various vehicles or carriers and processing aids helpful for forming the desired dosing form. Liquid forms suitable for oral administration may include a suitable aqueous or non- aqueous vehicle with buffers, suspending and dispensing agents, colorants, flavors and the like. Solid forms may include, for example, any of the following ingredients, or compounds of a similar nature: a binder such as macrocrystalline cellulose, gum traga- canth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring. Injectable compositions are typically based upon injectable sterile saline or phosphate- buffered saline or other injectable carriers known in the art. As above mentioned, the sulfonamide compound of formula I in such compositions is typically a minor compo- nent, frequently ranging between 0.05 to 10% by weight with the remainder being the injectable carrier and the like. The above described components for orally administered or injectable compositions are merely representative. Further materials as well as processing techniques and the like are set out in Part 8 of Remington' 's Pharmaceutical Sciences, 17 th Edition, 1985, Marck Publishing Company, Easton, Pennsylvania, which is incorporated herein be reference. The compounds of this invention can also be administered in sustained release forms or from sustained release drug delivery systems. A description of representative sustained release materials can also be found in the incorporated materials in Remington 's Pharmaceutical Sciences. In the following the present invention shall be illustrated by means of some examples which are not construed to be viewed as limiting the scope of the invention. The HPLC, NMR and MS data provided in the examples described below were obtained as followed. The following abbreviations are hereinafter used in the accompanying examples: min (min-ute), hr (hour), g (gram), mmol (millimole), m.p. (melting point), eq (equivalents), mL (milliliter), μL (microliters), mL (milliliters), ACN (Acetonitrile), Boc (bu- toxycarbonyl), CDC1 3 (deuterated chloroform), cHex (Cyclohexanes), DCM (Dichloromethane), DECP (Diethylcyanophosphonate), DIEA (Diisopropylethylamine), DIG (Diisopropyl carbodiimide), DMAP (4- Dimethylaminopyridine) DMF (Dimethyl- formamide), DMSO (Dimethylsulfoxide), DMSO-dg (deuterated dimethylsul-foxide), EDC (l-(3-Dimethyl-amino-propyl)-3-ethylcarbodiimide), EtOAc (Ethyl acetate), Et 2 O (Diethyl ether), Fmoc (9-fluorenylmethoxycarbonyl), HOBt (1-Hydroxybenzotriazole), K 2 CO 3 (potassium carbonate), NaH (Sodium hydride), NaHCO 3 (Sodium bicarbonate), nBuLi (n-Butyllithium), TBTU (O-Benzotriazolyl-N,N,N',N'-tetramethyluronium- tetrafluoroborate), TEA (Triethyl amine), TFA (Trifluoro-acetic acid), THF (Tetrahy- drofuran), TMOF (trimethylorthoformate), MgSO (Magnesium sulfate), PetEther (Pe- troleum ether), rt (room temperature). Examples Example 1 (Protocole E; see Schemes 1, 3 & 6) Preparation of 3-Methoxy-N-{ r5-({4-r(4-trifluoromethylbenzyl)aminolpiperidin-l- yl }sulfonyl)thien-2-yl1methyl Ibenzamide (1) I r(3-methoxybenzoyl amino1methyl)thiophene-2-sulfonyl chloride (la) To a solution of 2-Aminomethylthiophene (10.6ml, 103mmol) and pyridine (9.1ml, 104mmol) in 100ml chloroform was added at 0°C a solution of 3-methoxybenzoyl- chloride (19.2g, 103mmol) in CH 2 C1 2 . The reaction was allowed to warm to rt. during lh and stirred for additional 3h. Water was added while 3-methoxy-N-(thien-2- ylmethyl)benzamide, (lb) (lO.lg) precipitated. The solid was filtered of and washed with water. The remaining organic layer was washed with brine, dried over MgSO4 and evaporated to dryness to afford additional (lb) (15.2g). The overall yield was 25.3 g (99.9%). (lb) was used for the next step without further purification. Chlorosulfonic acid (5.62ml, 84mmol) was dissolved in 20ml CH 2 C1 2 and added to a solution of (lb) (11. Og, 42mmol) in 100ml CH 2 C1 2 under vigorous stirring. A gummy solid was formed and the reaction mixture was stirred for 3h. The reaction was quenched with ice, and ice cold ΝaHCO3 solution was added to reach pH8.5. The aque- ous layer was washed twice with CH 2 C1 . Tetrabutylammoniumhydroxide (40% in water) (32ml, 50mmol) was added to the aqueous layer, while a solid was formed. The precipitate was extracted into CH 2 C1 2 and the aqueous layer was washed 3x with CH 2 C1 2 . The combined organic layers were dried over MgSO4 and evaporated to dryness to afford a slightly colored foam of Tetrabutylammonium 5-{ [(3-methoxybenzoyl)- amino]methyl}thiophene-2-sulfonate (lc) (24g, 97%). NMR spectra indicated pure compound, which was used for the following chlorination step. To a solution of (lc) (2.0g, 3.4mmol) in 50ml CH 2 C1 2 was added triphosgene (800mg, 2.7mmol, 2.3eq.), dissolved in 10ml CH 2 C1 2 . To this reaction mixture DMF (0.1ml, 1.4mmol) was added dropwise during 10', while gas evolution could be observed. The gases were trapped at the outlet of the reaction flask in a 2N NaOH solution. The reaction mixture was stirred for 3h, and the crude was directly filtered through silica gel using EtOAc/hexane 1:2 as eluent. An orange solid could be isolated which was re- crystallised from cyclohexane/ CH 2 C1 2 . (la) (730mg, 60%) was obtained as colorless needles. 1H NMR (CDC1 3 ) 8.83 (t, J = 1.5 Hz, IH), 8.35 (t, J = 7.5Hz, IH), 7.76 (t, J = 4.1 Hz, IH), 7.70-7.58 (m, 3H), 7.52-7.40 (m, 2H), 7.05 (t, /= 3.8 Hz, IH). 1 - F(5- { r(3-Methoxybenzoyl amino1methyl }thien-2-yl sulf onyllpiperidin-4-ammonium trifluoroacetate (Id) To a solution of 5-({ [1 -(3 -Methoxybenzoyl] -amino }-methyl)-thiophene-2-sulf onyl chloride (la) (8g, 23 mmol) and DIEA (8.7 ml, 50.9 mmol) in 100 ml CH 2 C1 2 was added a solution of 4-Boc-amino-piperidine (5.5g, 27.7 mmol) in 50ml CH 2 C1 2 . The reaction mixture was stirred for 4h. Excess of amines were removed by extraction with HC1 (IN). The dried organic layer was evaporated to dryness. Recrystallization provided 8.3g (71%) of pure tert-butyl l-[(5-{ [(3-Methoxybenzoyl)amino]methyl}thien-2- yl)sulfonyl]piperidin-4-ylcarbamate, (le). 1H NMR showed pure product , which was deprotected according to standard protocols using TFA. The deprotected crude product was precipitated with Diethylether to provide 8.43g (82%) of (Id): H 1 NMR (DMSO- d6) 59.29 (t, J = 5.8 Hz, IH), 7.88 (m, 3H), 7.48-7.36 (m, 4H), 7.17 (d, J= 3.7 Hz, IH), 7.11 (d, J = 6.8 Hz, IH), 4.66 (d, J = 5.6 Hz, 2H), 3.79 (s, 3H), 3.61 (d, J = 11.7 Hz, 2H), 3.09 (m, IH), 2.43 (t, J= 11.1 Hz, 2H), 1.96 (d, J = 11.1 Hz, 2H), 1.54 (dd, J = 11.9, 3.7 Hz, 2H), M/Z APCI: 410.1 (M+1), 408.2 (M-l). 3-Methoxy-N- 1 T5-( 14- r(4-trifluoromethylbenzyl)amino1piperidin- 1-yl I sulfonyl)thien-2- yllmethyllbenzamide (1) (Id) (50mg, 0.1 mmol) was dissolved in 2 ml DCM and neutralized with DIEA (18μl, O.lmmol) to pH 7. To this solution was added 4-Trifluoromethylbenzaldehyde (18mg, 0.11 mmol), and the reaction was stirred for 30', followed by the addition of acetic acid (6ul, 0.1 mmol) and Sodium triacetoxyborohydride (28mg, 0.14 mmol). The reaction was stirred at r.t. for 4h, diluted with ethylether and quenched with ΝaOH (IN) to reach pH 9. The organic layer was washed with brine, dried over MgSO 4 and evaporated to dryness. The crude was purified by flash chromatography to obtain 51 mg of pure (1) (91%) as a colorless solid: mp.of HC1 salt: 235-236°C, H 1 ΝMR (DMSO-d 6 ) £9.29 (t, J = 5.8Hz, IH), 7.66 (d, J= 8.3 Hz, 2H), 7.65-7.40 (m, 6H), 7.19 (d, J= 3.8 Hz, IH), 7.15 (dd, J = 7.9, 1.5 Hz, IH), 4.70 (d, J= 5.6 Hz, 2H), 3.83 (s, 3H), 3.77 (d, b, 2H), 3.41 (d, b, 2H), 2.61-2.40 (m, 3H), 1.93 (m, 2H), 1.42 (m, 2H), M/Z APCI: 568.6 (M+1), 566.6 (M-l). Alternatively 1 can be synthesised in a parallel solution phase approach: (Id) (50mg, 0.1 mmol) was suspended in 2 ml DCE using parallel synthesizer Quest ® 210. The suspension was neutralized with DIEA (18μl, O.lmmol) to pH 7, while (lc) is dissolved. To this solution was added 4-Trifluoromethylbenzaldehyde in lOOμl DMF (18mg, 0.11 mmol), and the reaction was stirred for 30' under Ar, followed by the addition of acetic acid (6ul, 0.1 mmol) and Sodium triacetoxyborohydride (28mg, 0.14 mmol). The reaction was stirred at r.t. overnight, diluted with DCE and quenched with NaHCO (sat.) to reach pH 9. The organic layer was washed with brine, dried over MgSO 4 and filtered into scintilation vials. 50 mg of polymer bound benzaldehyde and 20 mg of Aminomethyl Merryfield resin were added and shaken overnight. The solution was filtered off, polymers were rinsed twice with solvent and the combined organic layers were evaporated to dryness at medium temperature for lh using a Savant Speed Vac " Plus vacuum centrifuge. The procedure afforded in a parallel array pure (1), as a colourless powder, which was upon treatment with HC1 in Diethylether transformed into its HC1 salt. The below listed compounds (designated as Example No.) were prepared in a similar way by following the above set out protocole and using the corresponding starting compounds (HPLC conditions: C8 Symmetry a- MeCN, 0.09%TFA, 0 to 100% (lOmin), b: MeCN, 0.09%TFA, 0 to 100% (8 min); Mass spectrum APCI). Example 63 (Protocole A; see Schemes 1, 3 & 7: Preparation of 4-chloro-N- \(5- { r4-(hexylamino)piperidin- 1 -yll sulfonyl ) -thien-2- vDmethyllbenzamide 4-Chloro-N-thiophen-2-ylmethyl-benzamide (63a) A solution of 4-chlorobenzoyl chloride (0.114 mol) in 50 ml dry CH 2 C1 2 was added over 30 min to a stirred solution of 2-aminomethyl-thiophene (0.137 mol) and 'P^ΝEt (0.25 mol) in CH 2 C1 2 (200 ml) at 0°C. A white solid was formed and the reaction was allowed to warm to room temperature over 1 h. The mixture was diluted with 200 ml of CH 2 C1 2 , washed twice with HC1 aq. (0.1Ν) and dried over MgSO . Evaporation of the solvents afforded 28 g (98%) of the title benzamide as a white solid: m.p. 153-54°C, 1H ΝMR (CDC1 3 ) δ 7.9 (d, J = 8.67 Hz, 2H), 7.58 (d, J = 8.67 Hz, 2H), 7.44 (dd, J = 3.77, 1.13 Hz, IH), 7.22 (d, J = 5.27 Hz, IH), 7.16 (dd, J= 3.39, 5.27 Hz, IH), 6.62 (br d, IH), 4.98 (d, J = 5.65 Hz, 2H). 5 -( { f 1 -(4-Chloro-phen yl -methanovn -amino I -methyl -thiophene-2-sulf onyl chloride (63b) Chlorosulfonic acid (20.1 ml, 198 mmol) in CH 2 C1 2 (80 ml) was added dropwise to a solution of (63a) (10 g, 40 mmol) in CH 2 C1 2 (500 ml) at -80°C. The mixture was allowed to reach room temperature in 5h.. The reaction mixture was poured on ice and quickly extracted with CH 2 C1 2 . The organic layer was dried over MgSO and the solvent was evaporated to dryness which afforded 8.8 g (63%) of desired sulfonyl chloride (63b); mp 133-35°C, 1H NMR (DMSO-d6) δ 9.21 (t, J = 6.4 Hz, IH), 7.87 (d, J = 8.67 Hz, 2H), 7.53 (d, J = 8.67 Hz, 2H), 6.91 (d, J= 3.39 Hz, IH), 6.77 (d, /= 3.39 Hz, IH), 4.53 (d, J= 3.77 Hz, 2H). 4-Chloro-N-(( 5-r(4-oxopiperidin-l-yl)sulfonyllthien-2-yl )methyl)benzamide (63c) A solution of 5-({ [l-(4-Chloro-phenyl)-methanoyl]-amino}-methyl)-thiophene-2- sulfonyl chloride (lb) (5.0g, 14mmol) in 100ml chloroform and a solution of 4- piperidinone hydrochloride monohydrate (4.3g, 28mmol) in 21ml of ΝaOH (2Ν) were stirred vigorously for 15h. The reaction was quenched with HC1 (2N) and the organic layer was extracted twice with HC1 (2N) and twice with brine. The dried organic phase affords after evaporation of chloroform 5.8g (99.5%) of (63c) as a colourless solid: 1H NMR (CDC1 3 ) 7.67 (d, J= 8.7 Hz, 2H), 7.42-7.38 (m, 3H), 6.99 (d, J= 3.8 Hz, IH), 6.53 (t, / = 5.3 Hz, IH), 4.74 (d, J = 6.0 Hz, 2H), 3.37 (d, J = 6.2 Hz, 4H), 2.50 (d, J = 6.2 Hz, 4H). 4-Chloro-N-r(5-(r4-(hexylamino)piperidin-l-yllsulfonyl|thien-2-yl)methyllbenz amide {63} A mixture of N-sulfonyl piperidone (63c) (3.01 g, 7.28 mmol), n-hexylamine (1.06 ml, 8.01 mmol), freshly powdered NaBH(OAc) 3 (3.1 g, 14.6 mmol), anhydrous 1,2- dichloroethane (150 ml), and THF (100 ml) was stirred for 80 min at 23°C. The mixture was concentrated on a rotary evaporator (T bath = 57°C), dissolved in EtOAc (500 ml), washed (brine:K 2 CO 3 sat, 4:1; 250 ml) and evaporated to give 4.1 g of crude material. The residue was dissolved in 50 ml hot acetone, adsorbed on silica gel, evaporated, loaded on a chromatography column (silica gel, diameter = 5.5 cm), and eluted (MeOH:CH 2 Cl 2 7:150). The chromatography was repeated to give 2.95 g (81%) of the title secondary amine as a white solid: 1H NMR (OMSO-d6) 9.37 (t, J = 5.8 Hz, IH), 7.90 (dt, J = 8.7, 2.2 Hz, 2H), 7.51 (dt, J = 8.5, 2.2 Hz, 2H), 7.16 (d, J = 3.8 Hz, IH), 4.65 (d, J = 5.8 Hz, 2H), 3.39 (dm, 7= 11.9 Hz, 2H), 3.60-3.00 (br. s, IH), 2.49 (ddd, J = 11.5, 9.8, 1.7 Hz, 2H), 2.43 (t, J= 6.9 Hz, 2H), 2.44-2.38 (buried m, IH), 1.82 (dm, J = 10.0 Hz, 2H), 1.38-1.14 (m, 10H), 0.83 (t, J= 6.7 Hz). 13 C NMR (DMSO-dό) 165.33 (C=O), 150.46 (thiophene, C2), 136.41 (chlorobenzamide, Cl), 133.86 (thiophene, C5), 132.42 (thiophene, C3), 132.37 (chlorobenzamide, C4, 129.22 (chlorobenzamide, C2 & C6), 128.52 (chlorobenzamide, C3 & C5), 126.27 (thiophene, C4), 52.53 (piperidine, C4), 46.07 (hexyl), 44.41 (piperidine, C2 & C6), 38.09 (thienyl-CH 2 ), 31.21 (piperidine, C3 & C5), 30.66 (hexyl), 29.49 (hexyl), 26.48 (hexyl), 22.06 (hexyl), 13.91 (hexyl). ). M/Z APCI : 498 (M+1), 496 (M-l). Anal. HPLC: R.t = 5.00 min (method a).C 23 H 32 ClN 3 O 3 S 2 Calc: C: 55.46%. H: 6.48%. N: 8.44%. Found: C: 54.19%, H: 6.52%, N: 8.22%. Alternatively (63) can be synthesised in a parallel solution phase approach: (63c) (20mg, 0.05 mmol) was dissolved in 2 ml THF using parallel synthesizer Quest ® 210. To this solution was added N-hexylamine in DCE (5.6mg, 0.06 mmol), and the reaction was stirred for 30' under Ar, followed by the addition of acetic acid (6ul, 0.1 mmol) and Sodium triacetoxyborohydride (28mg, 0.14 mmol). The reaction was stirred at r.t. for 4h, diluted with DCE and quenched with NaHCO 3 (sat.) to reach pH 8.5. The organic layer was washed with brine, dried over MgSO 4 and filtered into scintillation vials. To each vial was added MP-TsOH (3eq.) and shaken overnight. The so- lution was filtered off and the polymer was rinsed extensively with DCE. To the polymer was than added 3 times 1ml NH 3 in EtOH and shaken each for lOmin. The polymer was washed and the combined ethanolic solution was evaporated to dryness at medium temperature for lh using a Savant Speed Vac ® Plus vacuum centrifuge. The procedure afforded in a parallel array pure (63), as a colourless powder, which was upon treatment with HC1 in Diethylether transformed into its HC1 salt. The below listed compounds (designated as Example No.) were prepared in a similar way by following the above set out protocole and using the corresponding starting compounds : Example 122 (Protocole L; see Schemes 2 & 7): Preparation of Ethyl 2-1 r4-(hexylamino)piperidin-l-yllsulfonyl)-5-i r(3-methoxy- benzoyDaminolmethyl }thiophene-3-carboxylate (122) Diallyl-thiophen-2-ylmethylamine (122a) A solution of 2-aminomethyl-thiophene (51.4 g, 956 mmol) and z ' -Pr 2 NEt (140 g, 1081 mmol) in CH 2 C1 2 (1 1) was placed in a 3-1 flask equipped with a condenser and an efficient magnetic agitation. Allyl bromide (115.7 g, 454 mmol) was added, whereupon the moderately exothermic reaction spontaneously reached the reflux temperature after 2 h. The mixture was stirred overnight (16 h), washed (NaHCO 3 sat.; brine), dried (MgSO ), and concentrated. The resulting oil was filtered over silica gel (EtOAc:hexane 1:4). The filtrate was concentrated and the filtration was repeated to afford 70.3 g (80%) of the title diallylamine as a brown-yellow oil, clean by NMR: 1H NMR (CDC1 3 ) £7.25 (br. d, J = 5.9 Hz, IH), 6.98 (br. dd, J = 5.1, 2.8 Hz, IH), 6.94-6.92 (m, IH), 5.99-5.86 (m, 2H), 5.29-5.18 (m, 4H), 3.85 (s, 2H), 3.16 (dd, J= 6.3, 0.9 Hz, 4H). 5-Diallylaminomethyl-thiophene-2-sulfonyl chloride (122b) A solution of the allyl-protected thiophene (122a) (6.2 g, 32.1 mmol) in Et 2 O was cooled to - 70°C by means of an acetone/dry ice bath. A solution of t-BuLi in pentane (21.38 ml, 1.5M, 32.1 mmol) was added over 2 min whereupon the internal temperature momentarily rose to -50°C and the mixture turned orange. After 10 min., SO 2 was bubbled for 2 min, which led to the immediate formation of a thick precipitate. The reaction was allowed to reach 0°C, and a suspension of NCS (4.63 g, 32.1 mmol) in THF (20 ml) was added, whereupon the slurry turned purple. After 45 min at r.t., the mixture was filtered over SiO 2 , eluting with EtOAc. Evaporation, dilution with EtOAc:hexane 1:5 and filtration over SiO 2 gave 5.0 g (53%) of the title sulfonyl chloride (122b) as a pale brown oil which was used without further purification. N.N-Diallyl-N-ir5-(l,4-dioxa-8-azaspiror4.51dec-8-ylsulfonyl thien-2-yl1methyl)amine (122c) Procedure A (from the isolated sulfonyl chloride (122b)). A solution of (122b) (5.84 g, 20 mmol) in CHC1 3 was cooled to 0°C, and treated with l,4-dioxa-8- azaspiro[4,5]decane (2.8 ml, 22 mmol) and Et 3 N (4.2 ml, 30 mmol), and warmed to 23 °C for 10 min. Dilution with EtOAc (100 ml), standard work-up (NaHCO 3 sat.; brine; MgSO ) and chromatography (EtOAc yclohexane 1:2) gave 7.57 g (95%) of the title sulfonamide as a colourless oil. Procedure B (from (122a), without isolation of the sulfonyl chloride (122b). A solution of the allyl-protected thiophene (la) (29.1 g, 150 mmol) in Et 2 O (440 g, 617 ml) was placed in a 1-1 three-necked flask (thermometer; argon; septum or SO 2 inlet) and cooled to - 74°C by means of an acetone/dry ice bath. A solution of t-BuLi in pentane (100 ml, 1.5M, 150 mmol) was added over 5 min whereupon the internal temperature momentarily rose to -64°C and the mixture turned pink. After 20 min., SO 2 (20 g, 312 mmol) was bubbled over 15 min. The SO 2 consumption was best monitored by placing the SO 2 bottle on a scale during the reaction The reaction mixture, which had turned to a thick, white wax was allowed to warm to room temperature over 2h. A suspension of NCS (30 g, 226 mmol) was added, and stirring was continued overnight, whereupon the slurry turned purple. The mixture was filtered (fritted glass), and the precipitate was carefully washed with CH 2 C1 2 (2 x 300 ml). The combined organic layers were cooled to 0 ° C under Ar, and treated with a solution of l,4-dioxa-8-azaspiro[4,5]decane (27.8 g, 194 mmol) and triethylamine (19.7 g, 194 mmol) in CH 2 C1 2 (200 ml). After 1 h, the mixture was washed (NaHCO 3 sat.; brine), dried (MgSO 4 ), and concentrated to afford 53 g (83%) of the title sulfonamide as yellow oil: 1H NMR (CDC1 3 ) £7.36 (d, /= 3.8 Hz, IH), 6.90 (br. d, J = 3.4 Hz, IH), 5.92-5.79 (m, 2H), 5.33-5.16 (m, 4H), 3.93 (s, 4H), 3.78 (s, 2H), 3.21 (t, 5.7 Hz, 4H), 3.13 (d, 6.2 Hz, 4H), 1.81 (t, 5.7 Hz, 4H). Ethyl 5-r(diallylamino)methyn-2-(l-4-dioxa-8-azaspiror4.51dec-8-ylsulfonyl thiophene- 3-carboxylate (122d) A solution of the sulfonamide (122c) (3.36 g, 8.43 mmol) in THF (120 ml) was cooled to -78°C and treated with t-BuLi (7.0 ml, 1.5M in hexane, 10.5 ml). After 5 min, the mixture was canulated into a cooled (-100°C; acetone/liquid N ) solution of ethyl chlo- roformate (6.45 ml, 67.5 mmol) in THF (60 ml). The reaction mixture was allowed to warm to -30° C over 2h, and then to 23 °C overnight. The mixture was concentrated on a rotary evaporator and diluted with EtOAc (250 ml). Standard work-up (H O; brine; MgSO ) and two chromatographies (EtOAcxyclohexane 1:4) afforded 1.48 (37%) of the title ethyl ester: 1H NMR (DMSO-d6) £7.36 (d, IH), 5.98-5.82 (m, 2H), 5.32-5.17 (m, 4H), 4.33 (q, J = 7.1 Hz, 2H), 3.92 (s, 4H), 3.85 (s, 2H), 3.32 (dd, J~ 6.0, 5.0 Hz, 4H), 3.17 (d, J = 6.0 Hz, 4H), 1.74 dd, J~ 6.0, 5.0 Hz, 4H), 1.33 (t, J = 7.2 Hz, 3H). Ethyl 2-(l,4-dioxa-8-azaspiror4.51dec-8-ylsulfonyl)-5-{r(3-methoxybenzoyl)aminol- methyl )thiophene-3-carboxylate (122e) A solution of the ethyl ester (122d) (1.47 g, 3.12 mmol) and NDMBA (1.07 g, 6.87 mmol) in CH 2 C1 2 (30 ml) was degassed by bubbling argon and sonicating. Then, Pd(PPh 3 ) (216 mg, 0.187 mmol) was added and the mixture was stirred at 23°C. After 2h, the mixture was cooled to -50°C, treated with Et 3 N (525 ul, 3.76 mmol) and 3- (methoxy)-benzoyl chloride (300ul, 2.13 mmol), and warmed to r.t. over 30 min. Dilution with EtOAc, standard work-up (H O; NaHCO 3 sat.; brine; MgSO ) and chromatography (EtOAc :cyclohexane 1:1) afforded 1.0 g (61%) of the title 3-methoxybenzamide: 1H NMR (DMSO- 6) 9.29 (t, / = 5.8 Hz, IH), 7.49-7.34 (m, 4H), 7.12 (ddd, J = 7.9, 2.6, 1.0 Hz, IH), 4.66 (d, J = 5.7 Hz, 2H), 4.27 (q, J= 7.2 Hz, 2H), 3.84 (s, 4H), 3.80 (s, 3H), 3.24 (dd, J~ 6.0, 5.0 Hz, 4H), 1.67 (dd, J~ 6.0, 5.0 Hz, 4H), 1.26 (t, J = 7.0 Hz, 3H). M/Z APCI: 525 (M + 1), 523 (M-l). Ethyl 5-{ r(3-methoxybenzoyl)aminolmethyl I -2- r(4-oxopiperidin- 1 -yDsulfonyll - thiophene-3-carboxylate (122f) A solution of the spiroketal (122e) (500 mg, 0.953 mmol) in acetone (5 ml) was treated with HC1 IN (2.5 ml) for 18 h at 48°C. Dilution with EtOAc and standard work-up (H 2 O; NaHCO 3 sat.; brine; MgSO ) gave 425 mg of a 9:1 mixture of the desired title ketone (83%) and of unreacted starting material (9%) (single spot by TLC). 1H NMR (CDC1 3 ) 7.37-7.35 (m, IH), 7.33-7.29 (m, 3H), 7.05 (ddd, J = 7.7, 2.6, 1.7 Hz, IH), 6.81 (t, J= 5.8 Hz, IH), 4.74 (d, J= 6.1 Hz, 2H), 4.31 (q, J= 7.1 Hz, 2H), 3.83 (s, 3H), 3.70 (t, J = 6.1 Hz, 4H), 2.52 (t, J= 6.2 Hz, 4H), 1.34 (t, J= 7.1 Hz, 3H). M/Z APCI: 481 (M + 1), 479 (M-l). Ethyl 5-{ r(3-methoxybenzoyl)aminolmethyl }-2-{ r4-(hexylamino ' )piperidin-l-yll- sulfonyl }thiophene-3-carboxylate (122) A solution of the ketone (122f) (86 mg, 0.18 mmol),n-hexylamine (26 ul, 0.20 mmol), and NaBH(OAc) 3 (75 mg, 0.36 mmol) in 1,2-dichloroethane (3 ml) was stirred for 3h at r.t.. Dilution with EtOAc, standard work-up (NaHCO 3 sat.; brine; MgSO 4 ) afforded 85 mg (84%) of the desired compound 122 as a white foam. The below listed compounds (designated as Example No.) were prepared in a similar way by following the above set out protocole and using the corresponding starting compounds. Example 127 (Protocole N; see Schemes 1 & 7) Preparation of N-1Y5-I r4-(heptylamino)azepan-l-yl1 sulfonyl )thien-2-yl)methyll-3- methoxy-benzamide (127) The corresponding 3-Methoxy-N-({ 5-[(4-oxoazepan-l-yl)sulfonyl]thien-2-yl } methyl)- benzamide (127a), was prepared according to Example 63 and could be isolated as colourless powder in quantitative yield (693 mg). M/Z APCI: 423.5 (M+1), 421 (M-l). ). Anal. HPLC: R.t = 4.97 min (method a). (127) was prepared according to the protocol example 63 and was isolated as colourless solid in 47% yield (12mg). 1H ΝMR (DMSO-d 6 ) 9.25 (t, J = 5.8 Hz, IH), 7.46-7.35 (m, 4H), 7.10 (m, 2H), 4.65 (d, J= 6.0 Hz, 2H), 3.79 (s, 3H), 3.29-3.20 (m, 2H), 3.12 (m, 2H), 2.58 (m, IH), 2.49 (m, 2H), 1.75 (m, 2H), 1.44-1.22 (m, 14H), 0.85 (t, J = 6.9 Hz, 3H). M/Z APCI: 522.5 (M+1), 520 (M-l). ). Alternatively, (127) can be synthesised in a parallel solution phase approach according to the synthesis described for (63). The following compounds (designated as Example No.) were prepared in a parallel fashion according to the above set out protocole. yl I sulfonyl thien-2-vnmethyl Ibenzamide (154) A solution of 63 (19.6 mg, 0.039 mmol) and pyridine 2-carbaldehyde (20 ul, 0.210 mmol) in THF (2.5 ml) was treated with NaBH(OAc) 3 (90 mg, 0.425 mmol) under argon at reflux over 16h. The mixture was cooled to r.t. and the excess aldehyde was removed with aminomethyl polystyrene resin (160 mg, 0.308 mmol, pre-suspended in 4 ml CH 2 C1 2 ) for 10 min at 23°C. Dilution with CH 2 C1 2 (10 ml), filtration over cottonwool, and standard work-up (H 2 O; brine; MgSO 4 ) afforded 17.8 mg (77%) of the title tertiary amine as a pale yellow oil. ). M/Z APCI : 589 (M+1), 587 (M-l). Anal. HPLC: R.t = 5.00 min (method a, 96% optical purity (254 nM)). In this protocol, pyridine-2-carbaldehyde could be replaced with other aldehydes, which include (but are not limited to): pyridine-3-carbaldehyde, pyridine-4-carbaldehyde, ben- zaldehyde, cycohexanecarbaldeyde. The following compounds were prepared in a parallel fashion according to the above set out protocole (HPLC conditions: C8 Symmetry a- MeCN, 0.09%TFA, 0 to 100%; (lOmin); b MeCN, 0.09%TFA, 0 to 100% (8min); Mass spectrum APCI). Example 164 (Protocole B; see Schemes 1 & 8) Preparation of 4-chloro-N-| ~ (5-| F3-(pentyla-rano)pyrcolidin-l-yl1-sulfonyl|thien-2- vDmethyllbenzamide (164) 4-chloro-N-r(5-{ r(3R)-3-hydroxypyrrolidin-l-yllsulfonyl|thien-2-yl)methyllbenzamide, (164a) To a suspension of R-3-pyrrolidinol hydrochloride (530mg, 4.29 mmol) and DIEA (0.75ml, 14.3mmol) in CH 2 C1 2 /DMF 1:1 was added a solution of 5-({ [l-(4-Chloro- phenyl)-methanoyl] -amino }-methyl)-thiophene-2-sulf onyl chloride (63b) (l.Og, 2.86 mmol). At the end of addition the suspension disappeared. The reaction mixture was stirred overnight. 100ml EtOAc were added and the excess of amine was extracted with HC1 (IN), followed by washings with brine. The organic layers were dried over MgSO 4 and evaporated to dryness to provide (164a) (1.14 g, 99.9%) as a colourless foam: H 1 NMR (DMSO d6) £9.34 (t, J = 5.8 Hz, IH), 7.89 (d, J = 8.7 Hz, 2H), 7.49 (d, J = 3.8 Hz, IH), 7.55 (d, J = 8.7 Hz, 2H), 7.13 (d, J = 3.8 Hz, IH), 4.95 (d, J = 3.4 Hz, IH), 4.65 (d, J= 5.6 Hz, 2H), 4.16 (m, IH), 3.40-3.20 (m, 5H), 3.00 (m, IH), 3.35-3.23 (m, 3H), 1.80-1.60 (m, 2H), M Z APCI: 401.2 (M+1), 398.9 (M-l). 4-chloro-N-(| 5- r (3-oxopyrrolidin-l-yl)sulfonyllthien-2-yl ImethyDbenzamide, (164b) At -80°C oxalylchloride (36mg, 0.28mmol) was dissolved in dry CH 2 C1 2 , while DMSO (50ul, 0.6 mmol) were added slowly. The solution was stirred under Ar for 15minutes. (164a) (lOOmg, 0.25mmol) was dissolved in 2ml CH 2 C1 2 , and this solution was added dropwise to the above reaction mixture at -80°C. The reaction was stirred for 15' at low temperature, before DIEA (0.21ml, 1.25mmol) was added. The reaction was stirred at - 80°C for 30 minutes and allowed to warm to rt. during 2h. A white solid was formed, the reaction was quenched with water and extracted with CH 2 C1 2 several times. The combined organic layers were dried over MgSO and evaporated to dryness. The crude was purified by flash chromatography on silica gel using EtOAc/cyclohexane 2:1 as eluent. (164b) (80mg, 80%) was obtained as a colourless solid.: H 1 NMR (CDC1 3 ) £ 7.72 (d, J = 8.7 Hz, 2H), 7.46 (d, J = 3.8 Hz, IH), 7.42 (d, J = 8.7 Hz, 2H), 7.08 (d, J = 3.8 Hz, IH), 6.59 (t, J = 5.8, IH), 4.80 (d, J = 6.0 Hz, 2H), 3.58 (t, J = 7.5 Hz, 2H), 3.50 (s, 3H), 2.54 (t, J = 7.5, 2H), 3.35-3.23 ( , 3H), 2.95 (m, 2H), 1.94 (m, 2H), 1.86 (m, 2H), 1.70-1.50 (m, 5H), 1.30-1.20 (m, 8H), 0.87 (t, J= 6.8, 3H), M/Z APCI 399.0 (M+1), 397.2 (M-l) 4-chloro-N-r(5-{r3-(pentylanιino pyrrolidin-l-yllsulfonyl}thien-2-yl)methyl1benzamide (164) (164b) was prepared according to example 63 and was isolated as colourless solid in 84% yield (15mg). M/Z APCI: 522.5 (M+1), 520 (M-l). ). Anal. HPLC: R.t = 4.62 min (method a). Alternatively, (164) can be synthesised in a parallel solution phase approach according to the synthesis described for compound (63). The following compounds (designated as Example No.) were prepared in a similar fashion according to the above set out protocole (HPLC conditions: C8 Symmetry a- MeCN, 0.09%TFA, 0 to 100% (lOmin); b MeCN, 0.09%TFA, 0 to 100% (8min); Mass spectrum APCI). Example 195 (Protocole C; see Schemee 1 & 2) Preparation of 3-methoxy-N-{ r5-({4-r(pentylamino)methyllpiperidin-l-yl|sulfonyl)- thien-2-yllmethyllbenzamide (195) N-r(5-i r4-(hydroxymethyl)piperidin-l-yl1sulfonyl|thien-2-yl)methyll-3-methoxy- benzamide. (195a) To a solution of 4-hydroxymethyl-piperidine (499mg, 4.33 mmol) and DIEA (1.5ml, 8.67mmol) in 15 ml CH 2 C1 2 was added slowly a solution of 5-({ [l-(3-methoxy-phenyl)- methanoyl] -amino }-methyl)-thiophene-2-sulf onyl chloride (l.Og, 2.89mmol) in CH C1 / DMF. The reaction mixture was stirred for overnight. 100ml of EtOAc were added and the excess of amines were removed by extraction with HC1 (IN). The dried organic layer was evaporated to dryness to provide 1.25 g (99.9%) of pure (135a) as a colour- less foam: H 1 ΝMR (DMSO d6) £9.26 (t, J = 5.8 Hz, IH), 7.55-7.25 (m, 4H), 7.16 (d, J = 3.8 Hz, IH), 7.11 (d, J = 9.4 Hz, IH), 4.66 (d, J = 6.0 Hz, 2H), 4.48 (m, IH), 3.80 (s, 3H), 3.59 (d, J= 11.7, 2H), 3.31 (b, m, IH), 3.20 (d, J = 6.0 Hz, 2H), 2.27 (t, J= 11.0 Hz, 2H), 1.72 (d, J = 11.0 Hz, m, 2H), 1.40-1.0 (m, 4H), M/Z APCI: 425.3 (M+1). 3-methoxy-N-{r5-({4-r(pentylamino)methyllpiperidin-l-yl)sulfonyl)thien-2-yll- methyl Ibenzamide. (195) (195a) (200mg, 0.47mmol) and Triphenylphosphine (247mg, 0.94mmol) were dissolved in dry DMF. To this solution was added at 0°C in small portions Ν-bromo- succinimide (167mg, 0.94mmol) as a solid. Each portion was added after the yellow color in the solution disappeared. At the end of the addition the yellow color remained and the reaction mixture was heated at 50°C for 90'. The hot reaction is poured into a vial followed by the addition of amylamine (410mg, 4.7mmol). The vial was sealed and heated at 65°C overnight. The reaction mixture was evaporated to dryness and the crude was purified by flash chromatography on silica gel using EtOAc/methanol 10:1 to ob- tain 180 mg (78%) of (196) as a colourless oil. H 1 ΝMR (CDC1 3 ) £7.43-7.25 (m, 4H), 7.05 (m, 2H), 6.75 (m, IH), 4.82 (d, J = 6.0 Hz, 2H), 3.76 (s, 3H), 3.77 (d, J= 11.7, 2H), 2.63 (d, J = 7.3 Hz, 2H), 2.54 (d, J = 6.8 Hz, 2H), 2.35 (t, J= 11.1, 2H), 1.85 (d, J = 11.1 Hz, m, 2H), 1.70-1.50 (m, 4H), 1.30-1.20 (m, 6H), 0.89 (t, J = 6.8, 3H), M/Z APCI: 494.2 (M+1). The below listed compounds (desinated as Example No.) were prepared in a similar way by following the above set out protocole and using the corresponding starting compounds (HPLC conditions: C8 Symmetry a- MeCN, 0.09%TFA, 0 to 100% (lOmin); b MeCN, 0.09%TFA, 0 to 100% (8min); Mass spectrum APCI). Example 198 (Protocole F: see Schemes 2 & 7) ; Preparation of 2-Oxo-N-({5-F(4- j r4-(trifluoromethyl benzynamino)-l-piperidinyl)- sulfonvn-2-thienyl)methyl -1.2-dihydro-3-pyridinecarboxamide (198) N-{r5-(L4-Dioxa-8-azaspiror4.51dec-8-ylsulfonyl)-2-thienvnmethyU-2-oxo- 2- dihydro-3 -pyridinecarboxamide 198a The bisallylamine 122c (22.9 g, 57.5 mmol, 1.0 eq), N,N'-dimethylbarbituric acid (NDMBA, 17.9 g, 156.1 mmol, 2.0 eq), and Pd(PPh 3 ) (3.32 g, 2.87 mmol, 0.05 eq) were dissolved in CH 2 C1 2 (250 ml). The solution was degassed by bubbling argon for 10 min, and stirred under Ar at r.t for 15h. Nerification by TLC (EtOAc :cyclohexane 1 : 1) indicated complete cosumption of the starting material. The mixture was evaporated, and redissolved in DMF (150 ml). Then, 2-hydroxynicotinic acid (9.59 g, 69.0 mmol, 1.2 eq), HOBt (9.32 g, 69.0 mmol, 1.8 eq), and EDC (16.5 g, 86.1 mmol, 1.5 eq) were added. After stirring overnight at r.t., the mixture was concentrated, diluted with EtOAc (500 ml), and rinsed with water (100 ml). The aqeous phase was reextracted twice with ethyl- acetate. The combined organic phases were concentrated, and the crude was redissolved in CH 2 C1 2 (500 ml), before resuming ΝaHCO 3 rinse. The crude was concentrated to give approx 31 g of material, which was dissolved in 80 ml of CHCl 3 :acetone 2:1. Upon standing for 1 h at r.t., a precipitated appeared, which was filtered and washed (EtOAc:cyclohexane 1:2) to give additional product (6.1 g, 24%). The rest was chor- matographed on the biotage Flash75 (short column, CHCl 3 :acetone 2:1) to give more product (3.6 g, 14%). Thus, the three products (precipitate 1, precipitate 2, and chro- matographed product) were combined to give a total of 17.9 g (70%) of the desired pyridone as a white solid. 1H NMR DMS0-d6) £12.51-12.61 (br. s, IH), 10.29 (t, J= 6.0 Hz, IH), 8.36 (dd, J = 7.2, 2.2 Hz, IH), 7.70-7.75 (br. d, J ~ 4.0 Hz, IH), 7.47 (d, J = 3.7 Hz, IH), 7.17 (d, J = 3.7 Hz, IH), 6.49 (dd, J~ 7,6 Hz, IH), 4.53 (d, J = 6.0 Hz, 2H), 3.82 (s, 4H), 3.00 (t, J = 5.7 Hz, 4H), 1.67 (t, J = 5.7 Hz, 4H). 2-Oxo-N-(|5-r(4-oxo-l-piperidinyl)sulfonyll-2-thienyl|methyl)- 2-dihydro-3- pyridinecarboxamide (198b) A solution of the ketal 198a (6.0 g, 13.7 mmol) in acetone (60 ml), HC1 aq. IN (30 ml) and cone. aq. formaldehyde (8 ml) was heated to 48 °C for 15h. The mixture was concentrated to a total weight of 46 g, whereupon an orange oil separated out, and CH 2 C1 2 was added (200 ml). The orange oil went in the organic phase, while water (27 ml) separated out and was removed. The CH 2 C1 2 layer was rinsed with a small amount of water (20 ml), dried (MgSO 4 ), and concentrated to afforded the crude ketone as hemi- aminal (5.1 g, 88%). A solution of the hemiaminal (5.1 g, 12 mmol) in acetone (8 ml) and HC1 aq. IN (4 ml) was heated at 49 °C for 15h. The mixture was poured into a separatory funnel contain- ing 200 ml EtOAc, and the aqueous layer was removed. Drying (MgSO 4 ), and concentration afforded 286 mg of the crude pyridinone 198b (81%) as a white solid very clean by NMR. 1H NMR (DMSO-d6) £ 12.57 (s, IH), 10.27 (t, J = 6.1 Hz, IH), 8.36 (dd, J = 7.1, 2.2 Hz, IH), 7.73 (dd, J= 6.3, 2.1 Hz, IH), 7.52 (d, J= 3.8 Hz, IH), 7.16 (d, J = 3.7 Hz, IH), 6.49 (dd, J = 7.1, 6.4 Hz, IH), 4.72 (d, J= 6.0 Hz, 2H), 3.32 (q, J= 6.2 Hz, 4H), 2.43 (q, J = 6.2 Hz, 4H). 2-Oxo-N-(l 5-l " (4-{ r4-(trifluoromethyl)benzynamino }-l-piperidinyl)sulfonyll-2- thienyl } methyl)- 1 ,2-dihydro-3-pyridinecarboxamide (198) A suspension of the ketone 198b (2.33 g, 5.89 mmol, 1.0 eq), 4- (trifluoromethyl)benzylamine (0.98 g, 5.59 mmol, 0.95 eq) and NaBH(OAc)3 (1.62 g, 7.66 mmol, 1.3 eq) in 1,2-dichloroethane (70 ml) was stirred for at r.t. After 3 days, it was poured in CH2C12 (600 ml), rinsed with sat. aq. NaHCO3 (100 ml), dried (MgSO4), and concentrated. The colourless oily crude was dissolved in MeOH (100 ml) and treated with 2 ml fuming HC1 (pre-diluted with 20 ml MeOH). After 30 seconds, a white precipitate started appearing. This was collected after 10 minutes by filtration to give the desired product as its HC1 salt, and in excellent purity (1.6 g, 47% yield). Concentration of the filtrate to 10 ml afforded more precipitate (0.6 g, 17% yield). Mp = 288-289 °C, 1H NMR (DMSO-d6) £12.5 (s, IH), 10.38 (t, J= 6.0 Hz, IH), 9.90- 9.70 (br.s, 1.5H), 8.37 (dd, J= 7.2 & 2.1 Hz, IH), 7.85-7.70 (m, 5H), 7.48 (d, /= 3.7 Hz, IH), 7.16 (d, J= 3.8 Hz, IH), 6.49 (t, J= 6.8 Hz, IH), 4.73 (d, J= 5.8 Hz, 2H), 4.24^1.16 (br s, 2H), 3.66 (d, J= 11.7 Hz, 2H), 3.20-3.05 (br. m, IH), 2.39 (t, J= 11.3 Hz, 2H), 2.19 (d, J= 10.7 Hz, 2H), 1.76 (qd, J= 11.5, 3.2 Hz, 2H). 19 F NMR (DMSO- d6) -61.64. The following compound was prepared in a similar fashion according to the protocole of example 198 described above : piperidinvD-sulf onyll -2-thienyl|methyl)benzamlde (205) A solution of the hydrochloride salt of 1 (50 mg, 0.08 mmol), DIEA (12 ul, 0.08 mmol), formaldehyde solution 37% aq. (32 ul, 0.4 mmol) and Sodiumcyanoborohydride (10 mg, 0.16 mmol) in THF were heated under reflux for 15h, whereupon complete alkyla- tion took place. The reaction was diluted with DCM and the inorganic salts were ex- tracted with water. The crude was dried over MgSO4, and the solution was evaporated to dryness. The oily residue was taken up in THF, IN HC1 in ether was added slowly upon which colourless crystalls of compound 205 were formed (yield: 51 mg, 97%). Anal. HPLC: R.t = 4.39 min (method b). M/Z APCI: 582.1 (M+1), 580.4 (M-l). The following compound was prepared in a similar fashion according to the example 205 described above : Example 207: (Protocole H; see Scheme 6) Preparation of 4-Chloro-N-r(5-{ r4-({iminor4-(trifluoromethyl)phenyl1-methyl}- amino)-l-piperidinvπsulfonvU-2-thienyl)methvπbenzamide 207 The corresponding l-[(5-{ [(4-Chlorobenzoyl)amino]methyl)thien-2-yl)sulfonyl]- piperidin-4-ammonium trifluoroacetate 208a was prepared according to the synthesis of Id. 202a was neutralized before use. 50 mg (0.12 mmol) of 208a were dissolved in 2 mis DCE. A solution of Trimethylaluminum in toluene (2M, 86 ul, 0.16 mmol) was added at 0°C under Argon. The reaction was stirred for 15 min. at 0°C, followed by 3h at r.t.. A solution of 4-Trifluoromethylbenzonitrile (41 mg, 0.24 mmol) in DCE was added slowly to the above reaction. The reaction was closed and heated at 70°C in an Argon atmosphere for 15h. The reaction vessel was cooled and the solution was diluted with DCE, followed by aqeuous extraction with brine. The organic layer was dried over MgSO4.. The starting material amine was sequestered by means of polymerbound iso- cyanate (3 eq.). The remaining solution was treated with polymerbound tosylate in order to trap the basic amidine. Rinsing the resins removed quantitatively the starting nitrile. The tosylate resin was ultimately treated with NH3 in MeOH to release the free amidine 208. The later was dissolved in THF, followed by treatment with IN HCl in ether affording the hydrochlride salt of 207 in pure form (35 mg, 48%). Anal. HPLC: R.t = 3.67 min (method b). M/Z APCI: 585.1 (M+1), 583 (M-l). Example 208 : Preparation of a pharmaceutical formulation The following formulation examples illustrate representative pharmaceutical compositions according to the present invention being not restricted thereto. Formulation 1 - Tablets A sulfonamide compound of formula I is admixed as a dry powder with a dry gelatin binder in an approximate 1:2 weight ration. A minor amount of magnesium stearate is added as a lubricant. The mixture is formed into 240-270 mg tablets (80-90 mg of active sulfonamide compound per tablet) in a tablet press. Formulation 2 - Capsules A sulfonamide compound of formula I is admixed as a dry powder with a starch diluent in an approximate 1:1 weight ratio. The mixture is filled into 250 mg capsules (125 mg of active sulfonamide compound per capsule). Formulation 3 - Liquid A sulfonamide compound of formula I (1250 mg), sucrose (1.75 g) and xanthan gum (4 mg) are blended, passed through a No. 10 mesh U.S. sieve, and then mixed with a previously prepared solution of microcrystalline cellulose and sodium carboxymethyl cellulose (11:89, 50 mg) in water. Sodium benzoate (10 mg), flavor, and color are diluted with water and added with stirring. Sufficient water is then added to produce a total volume of 5 mL. Formulation 4 - Tablets A sulfonamide compound of formula I is admixed as a dry powder with a dry gelatin binder in an approximate 1:2 weight ratio. A minor amount of magnesium stearate is added as a lubricant. The mixture is formed into 450-900 mg tablets (150-300 mg of active sulfonamide compound) in a tablet press. Formulation 5 - Injection A sulfonamide compound of formula I is dissolved in a buffered sterile saline injectable aqueous medium to a concentration of approximately 5 mg/ml. Example 209 : Biological assays Biological Results The biological activities of the compounds according to formula I may be assessed us- ing the following in vitro and in vivo assays. JNK2 and -3 in vitro assays: The phosphorylation of c-jun by JNK2 or JNK3 may be followed by monitoring the incorporation of 33 P into c-jun following the protocol below. The inhibitory activity of the compounds according to formula I, in respect of c-jun phosphorylation through JNK, is determined by calculating the phosphorylation activity of a JNK in the presence or absence of the test compounds according to formula I. JNK3 and/or -2 assays are performed in 96 well MTT plates: incubation of 0.5 μg of recombinant, pre-activated GST-JNK3 or GST-JNK2 with 1 μg of recombinant, biotinylated GST-c-Jun and 2 μM 33 γ-ATP (2 nCi/μl), in the presence or absence of compounds according to formula I and in a reaction volume of 50 μl containing 50 mM Tris-HCl, pH 8.0; 10 mM MgCl 2 ; 1 mM Dithiothreitol, and 100 μM NaVO 4 . The incubation is performed for 120 min. at R.T and stopped upon addition of 200 μl of a solu- tion containing 250 μg of Streptavidine-coated SPA beads (Amersham, Inc.) * , 5 mM EDTA, 0.1% Triton X-100 and 50 μM ATP, in phosphate saline buffer. After incubation for 60 minutes at RT, beads are sedimented by centrifugation at 1500 x g for 5 minutes, resuspended in 200 μl of PBS containing 5 mM EDTA, 0.1% Triton X- 100 and 50 μM ATP and the radioactivity measured in a scintillation β counter, fol- lowing sedimentation of the beads as described above. By replacing biotinylated GST-c Jun with biotinylated GST- ! ATF 2 or biotinylated myelin basic protein, this assay may also be used to measure inhibition of pre-activated p38 and ERK MAP Kinases, respectively. The values indicated in respect of JNK2 and 3 refer to the IC 50 (μM), i.e. the amount necessary to achieve 50% inhibition of JNK3 and JNK2. The tested compounds according to formula I display an inhibition (IC 50 ) with regard to JNK3 of less than 0.4 μM, more preferred, equal or less than 0.2 μM. The tested compounds according to formula I display an inhibition (ICs 0 ) with regard to JNK2 of less than 0.2 μM, more preferred, equal or less than 0.02 μM. Compounds of Examples 1, 63, 86, 198 display an inhibition (IC 50 ) with regard to JNKl of between 0.1-0.7 μM. Sympathetic Neuron Culture and Survival Assay The ability of the compounds according to formula I to increase the survival rate of neuronal cells having been induced to cell death was assessed using the following protocol Sympathetic neurons from superior cervical ganglia (SCG) of new-born rats (p4) are dissociated in dispase, plated at a density of 10 4 cells/cm 2 in 48 well MTT plates coated with rat tail collagen, and cultured in Leibowitz medium containing 5% rat serum, 0.75 μg/mL NGF 7S (Boehringer Mannheim Corp., Indianapolis, IN.) and arabinosine 10 5 M. Cell death is induced at day 4 after plating by exposing the culture to medium contain- ing 10 μg/mL of anti NGF anti-body (Boehringer Mannheim Corp., Indianapolis, IN.) and no NGF or arabinosine, in the presence or absence of sulfonamide inhibitors. 24 hours after cell death induction, determination of cell viability is performed by incubation of the culture for 1 hour, at 37°C in 0.5 mg/mL of 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT). After incubation in MTT cells are resuspended in DMSO, transferred to a 96 MTT plate and cell viability is evaluated by measuring optical density at 590 nm. The results of this assay with various test compounds demonstrate that compounds of Formula I are rescuing neurons from cell death (% neurons alive between 10 and 80). The above assay with test compound (63) demonstrates a rescue rate of 35 % of SCG cells at 3 μM. 11-2 Release Assay: The ability of the compounds according to formula I to modulate the inflammatory response by inhibiting the release of IL-2 was assessed using the following protocol JNK pathway activation triggers the production of inflammatory cytokines such as IL-2. JNK can be activated by external stimuli such as PMA and lonomycine and IL-2 production can be measured via an IL-2 ELISA test. Comparative measurements with and without the compounds of the invention according to the following protocol measure the ability of the compounds to prevent to stress-mediated IL-2 release. Jurkat cells, a human T cell leukemia cell line (American Type Culture Collection # TIB 152) were cultured in RPMI 1640 medium (Gibco, BRL) supplemented with 10% of heat-activated fetal calf serum (FCS), Glutamine and Penstrep. The cell suspension in the medium is diluted to give 2.10 6 cells/mL. The cells were plated (2.10 5 cells/well) on a 96-well plate containing different concentrations of a compound according to formula I (final concentration of compounds, 10, 3, 1, 0.3, 0.1 μM). This mixture is incubated 30 minutes at 37°C in a humidified CO atmosphere. Cells were then treated with 10 μl PMA (Phorbolmyristate-13 Acetate- 12) + lonomycine (0.1 μM and 1 μM final concentration) in all wells except negative control. In wells without compounds, 10 μl of RPMI 2% DMSO (=0.1% final) is added. Cells are incubated 24 hours at 37°C and then the supernatant harvested (freeze at -20°C if not used the same day) prior to performing IL- 2 ELISA test on the supernatant. IL-2 ELISA Assay: IL-2 release into the medium by (PMA + Iononomycin)-stimulated Jurkat cells, in presence or absence of test compounds may be assayed by ELISA. Following the procedure described below. Monoclonal anti-human IL-2 antibody (MAB602) (capture), biotinylated anti-human IL-2 antibody (BAF202) (detection) and recombinant human IL-2 (202-IL-010) (standard) from From R&D Systems are used. Plate preparation 100 μl capture antibody diluted in PBS at 5 μg/mL (PBS- Tween 0.05%) are transferred into a 96 well ELISA plate and incubated overnight at room temperature. Each well is aspirated and washed 3 times with wash buffer (PBS- Tween 0.05%). After the last wash, the plate is damped. Assay procedure 1. 100 μl of sample or standard are added (2000, 1000, 500, 250, 125, 62.5, 31.25pg/mL) and incubated 2 hours at room temperature. 2. 3-time-wash 3. 100 μl of biotinylated anti -human IL-2 at 12.5 ng/mL are added and incubated 2 hours at room temperature. 4. 3-time-wash 5. 100 μl streptavidin-HRP (Zymed #43-4323) at 1 : lO'OOO are added and incubate 30 minutes at room temperature. 6. 3-time-wash 7. 100 μl substrate solution (citric acid Na 2 HPO 4 (1:1) + H 2 O 2 1 :2000 + OPD) are added and incubated 20-30 minutes at room temperature. 8. 50 μl of stop solution (H 2 SO 20%) are added to each well. 9. Optical density is measured using a microtiter plate reader set to 450 nm with correction at 570 nm. The result of this assay shows that various test compounds decrease the production of IL-2 of more than 30% at 3 μM. For instance compounds (1), (64) and (68) show an IC 50 value of less 800 nM in this assay. C-Jun Reporter Assay The phosphorylation of the transcriptional factor, c-jun, by JNK in the MAP kinase signal transduction pathway can be followed via a trans-reporting system such as the commercially available PathDetect ® (32). Inhibition of phosphorylation by compounds according to formula I can then be assessed. A trans-reporting system allows one to follow, via Luciferase activity, the activation status of a fusion trans-activator protein. The trans-activator protein consists of the activation domain of the transcriptional factor of interest (c-jun) fused with a yeast tran- scriptional activator, GAL4 DNA binding domain (dbd). The GAL4 dbd has the advantage that no known mammalian transcriptional factors can bind to it and therefore the background noise of the assay is very low. In the present case, Hela luciferase reporter-c-Jun (HLR-c-Jun) cell lines which constitutively express GAL4-cJun were used. The MEKK-1 gene was inserted. MEKK-1 is a MAPKKK which triggers the activation of JNK. Expression of wild type MEKK-1 is sufficient for JNK activation (33). Once, JNK is activated it can induce the phosphorylation of the c-jun domain of the fusion trans-activator protein (GAL4dbd -cJun) which forms a dimer. The dimer is then is able to bind to a GAL4 upstream activating sequence (GAL4 UAS) of the reporter which activates Luciferase expression. Luciferase expression is detected by luminescence using a simple assay such as Dual- Luciferase ® Reporter Assay System (34) in which Renilla is used as a "control reporter". Inhibition of JNK is observed as a decrease in Luciferase expression and detected by a decrease in luminescence. Cell culture HLR-c-Jun cells are cultured in DMEM High Glc supplemented with 10% FCS (Sigma), 2mM Glutamine (Gibco), P/S, Hygromycin b lOOμg/mL and G418 250μg/mL. Cell culture preparation Cell Banks The cells are stored frozen in cryotubes under liquid nitrogen, as 1.8 mL volumes of cell suspension in culture medium containing 10% dimethyl sulfoxide. Cell culture thawing When necessary, frozen vials of cells are thawed rapidly at 37°C in a water bath by gently swirling up to semi-complete thawing. Then the cell suspension is added to 10 mL of culture medium and then centrifuged for 5 minutes at 1200 rpm. The supernatant is removed and the cell pellet reconstituted in the medium. The flasks are incubated at 37° C in an atmosphere of 5 % CO 2 . Cell passage The cells are serially sub-cultured (passaged) when 80% confluent monolayers have been obtained. The medium of each flask is removed and the monolayer is washed with 10-15 mL of phosphate buffer solution (PBS). Trypsin-EDTA solution is added to the cell monolayer, incubated at 37° C and tapped gently at intervals to dislodge the cells. Complete detachment and disaggregation of the cell monolayer is confirmed by microscopy examination. The cells are then re- suspended in 10 mL of complete medium and centrifuged for 5 minutes at 1200 rpm. The supernatants are discarded, the cells are re-suspended in culture medium and diluted 1/5 in 175 cm 2 flasks. Day 0 morning Prepare cells for transfections The cells of near-confluent cultures are detached and disaggregated by treatment with trypsin as described above. The cells are re-suspended in culture medium and counted. The cell suspensions are diluted with medium to give about 3.5xl0 6 cells/mL and lmL μl of cell suspension are put onto 2 10cm culture dishes containing 9 mL of culture medium. The plates are incubated at 37° C in a humidified atmosphere of 5 % CO 2 in air. Day 0 evening Transfections Control :0.2μg pTK Renilla, 5.8μg pBluescript KS, 500μl OPT EM (GIBCO), 18μl Fugene 6. Induced :0.1μg pMEKKl, 0.2μg pTK Renilla, 5.7μg pBluescript KS, 500μl OPTIMEM (GIBCO), 18μl Fugene 6 30' RT. The transfection mixture is added to the plated cells. The plates are incubated over night at 37° C in a humidified atmosphere of 5 % CO 2 in air. Day l A 96 wells plate (100 μl of culture medium per well) is prepared. Negative control (vehicle): 2μl of DMSO is added to the lOOμl (in triplicate). 2 μl of compound according to formula I stock dilutions (3, 1 and O.lmM in 100% DMSO) are added to the lOOμl (in triplicate). The transfected cells are trypsinised and re-suspended in 12 mL of culture medium. lOOμl of the dilution are added to each of the 96 wells plate. The plate is incubated over night at 37° C in a humidified atmosphere of 5 % CO 2 in air. Day 2 Test procedure: Dual-Luciferase ® Reporter Assay System (34). The medium is removed from the plate and the cells are washed two times with lOOμl PBS. Lysis reagent is applied (Passive Lysis Buffer, PLB). Into each culture well 5μl of IX PLB are dispensed. The culture plates are placed on a rocking platform or orbital shaker with gentle rocking/shaking to ensure complete coverage of the cell monolayer with IX PLB. The culture plates are rocked at room temperature for 15 minutes. 20 μl of the lysate are transferred into a white opaque 96 well plate. The luminometer reading is recorded. - 50 μl of Luciferase Assay Reagent II are injected and readings are recorded at 5 and 10 minutes. 50μl of Stop & Glo ® Reagent are injected and readings are recorded at 5 and 10 minutes. The relative luminescence is then measured: RLU Luciferase/RLU Renilla. The result of this assay shows that various test compounds inhibit more than 20% of the activity of JNK at 10 μM. For instance compounds (1), (10), (11) or (117) display in this assy an IC 50 value of less than 0.7 μM. LPS induced endotoxin shock in mice The ability of the JNK inhibitors described in formula I to significantly reduce the level of inflammatory cytokines induced by LPS challenge was assessed using the following protocol: Endotoxins are the lipopolysaccharides (LPS) constituents of the outer membrane of Gram negative bacteria. Response to LPS has been shown to involve the activation of different cell populations and to lead to the expression of various inflammatory cytoki- nes that include tumor necrosis factor-alpha (TNF ) and interferon gamma (IFN-γ). As LPS is known to stimulate the activation of various MAP kinase pathways, including JNK (35), the ability of JNK inhibitors can be tested after the JNK signaling pathway has been switched on by a LPS challenge. The activity as JNK inhibitors of compounds of formula may be assessed after a LPS challenge using the following protocol: LPS (S. abortus-Galanos Lab.-) is injected (200 μg/kg, i.v.) to Male C57BL/6 mice to induce endotoxin shock. Compounds according to formula I (0.1, 1, 10 mg/kg) or NaCl (200uM) are injected intravenously (10 mL/kg) 15 min before the LPS challenge. Hepa- rinized blood was obtained from the orbital sinus at different time points after the LPS challenge, and the blood was centrifuged at 9'000 rpm for 10 min at 4° C to collect su- pernatant. Measurement of cytokines production such as TNF and IFNγ by mouse is performed with an ELISA kit such as Duoset ® DY410 for TNFα and DY 485 for IFN γ. Other ELISA assays such as described in (36) can be used. Thus, the compound of Example (63) shows an inhibition of IFN γ production of 65% at 1 mg/kg and 40 % inhibition of TNFα production at 10 mg/kg. Global Ischemia in Gerbils The ability of the JNK inhibitors described in formula I to protect cell death during a stroke event was assessed using the following protocol: The gerbil bilateral carotid occlusion is a well-described animal model of acute ische- mic stroke and involves relatively easy surgical techniques. The neuronal degeneration in the hippocampus develops over several days and is often referred as "delayed neuronal death". In addition, the neurodegeneration observed his- tologically is obvious and easily quantified (37). Furthermore, the histopathology seen in the gerbil is similar to that observed in the hippocampal CA1 region of the human brain following a cardiac arrest. Behavior observations, such as memory tests, could even be performed in the case of gerbils. This kind of tests for appreciation of the degree of recovery is not easily manageable in other models such as in rat whose learning abilities are much poorer (38). The neuroprotective effect according to formula I to protect may be assessed using the gerbil global ischemia model and such a protocol: -1- METHOD * Surgery - Anesthesia with isoflurane (0.5-4%). - The common carotid arteries (left and right) are freed from tissue. - Occlusion of the arteries using Bulldog microclamps during 5 min. - Removal of clamps (reperfusion) - Stabulation of the animals under heating lamp until awake. - Stabulation of the animals in the animalry in individual cages. * Sacrifice of the animals - 7 days after ischemia (Decapitation or overdose of pentobarbital). - Sampling of the brain. * Histological parameters - Freezing of the brain in isopentane (-20°C) - Slicing of the hippocampus using a cryo-microtome (20 μm). - Staining with cresyl violet method - Evaluation of the lesions (in CA1/CA2 subfields of the hippocampus) by a modified Gerhard & Boast score (39). -2- TREATMENT - Administration of the compound according to formula I or the vehicle: 15 min, 24 hours and 48 hours after reperfusion (5-10 min after the recovery of the anesthesia). - Standard protocol 50 animals : 5 groups of 8 (group A : control, groups B-D : test article at 3 doses and group E : reference compound (Orotic acid 3x300 mg kg, ip). Thus, the compound of Example (68) shows an inhibition of global ischemia of 64% (% inhibition of total lesion) at 80 mg/kg. Solubility of compounds of formula (I) The compounds have been assessed in respect of their solubility in water, at a pH of 7.4 at room temeprature. In general the solubility of compounds of formula (I) is in a range of at least 50 μg/mL solvent, more preferably of at least 100 μg/mL solvent. For instance compounds (63), (163), (198) display a solubility in water of at least 200 μg/mL solvent. References: 1. Davis, Roger J., Signal Transduction by the JNK Group of MAP Kinases. Cell, 2000, 103: 239-252. 2. Chen, Yi-Rong and Tan, Tse-Hua. The c-Jun N-terminal kinase pathway and apoptotic signaling. International Journal of Oncology, 2000 , 16: 651-662 3. Ip, YT. and Davis RJ, Signal transduction by the c-Jun N-terminal kinase (JNK) from c-Jun N-terminal kinase (JNK) from inflammation to development Curr Opin Cell Biol 1998,10:205-219. 4. 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Claims: Claims 1. Sulfonamide derivatives according to formula I with its geometrical isomers, in an optically active form as enantiomers, dias- tereomers, as well as in the form of racemates, as well as pharmaceutically acceptable salts thereof, wherein Ar 1 and Ar 2 are independently from each other aryl or heteroaryl, X is O or S; R 1 is hydrogen or a Cι-C 6 -alkyl group, or R 1 forms a 5-6-membered saturated or unsaturated ring with Ar 1 ; n is an integer from 0 to 5; Y is a 4- 12-membered saturated cyclic or bicyclic alkyl containing a nitrogen, which forms a bond with the sulfonyl group of formula I, said 4-12-membered saturated cyclic or bicyclic alkyl is substituted with at least one ionisable moiety to which a lipophilic chain is attached. 2. A sulfonamide derivative according to any of the preceding claims, wherein Ar 1 and Ar 2 are independently selected from the group consisting of phenyl, thienyl, furyl, pyrrolo, pyridyl, optionally substituted by -Co-alkyl, Ci-C 6 -alkoxy, C 2 - C 6 -alkenyl, C 2 -C 6 -alkynyl, amino, acylamino, aminocarbonyl, -Cβ- alkoxycarbonyl, aryl, carboxyl, cyano, halogen, hydroxy, nitro, sulfonyl, -C ό - thioalkoxy. 3. A sulfonamide derivative according to claim 2, wherein Ar 1 is a phenyl. 4. A sulfonamide derivative according to any of the preceding claims, wherein Ar' is a thienyl or furanyl group. 5. A sulfonamide derivative according to any of the preceding claims, wherein Ar is selected from a halogenophenyl, nitrophenyl, hydroxyphenyl, alkoxyphenyl, pyridyl, 3,4,-dihydroxyphenyl, thioxo-dihydropyridine or its tautomer, pyrazole and X is O, R 1 is hydrogen, n is 1, Ar 2 is thienyl or furanyl. 6. A sulfonamide derivative according to claim 5 wherein Y is a pyrrolidine, an azepan or a piperidine moiety of the below formulae whereby R 6 is selected from the group consisting of hydrogen, -C ό -alkyl, - Cβ-alkoxy, OH, halogen, nitro, cyano, sulfonyl, oxo (=O), sulfoxy, acyloxy, thioalkoxy and where R 6 is not hydrogen, n' is an integer from 0 to 4, preferably 1 or 2, whereby at least one of L 1 and/or L 2 is an ionisable moiety to which a lipophilic chain is attached. 7. A sulfonamide derivative according to claim 6, wherein R is H, L is H, L is - NR 3 R 3 ; where at least one of R 3 and R 3 is not hydrogen, but a substituent selected from the group consisting of straight or branched C 4 -Cι 8 -alkyl, aryl-Ci- C 18 -alkyl, heteroaryl-C 2 -C 18 -alkyl, -Cn-alkyl substituted with a C 3 -C 12 - cycloalkyl or -bicyclo or -tricyloalkyl, and whereby said alkyl chain may contain 1-3 O or S atoms. 8. A sulfonamide derivative according to claim 7, wherein L 1 is -NHR 3 ; where R 3 is a straight or branched C -C 12 -alkyl, preferably a C 6 -C 12 -alkyl, optionally substituted with a cyclohexyl group or a benzyl group. 9. Sulfonamide derivatives according to claim 8, wherein Y is a piperidine group L 1 is -NHR 3 ; where R 3 is a straight or branched C 6 -Cι 2 -alkyl, preferably a C 8 - C 12 -alkyl, or a benzyl group. 10. A sulfonamide derivative according to any of the preceding claims selected from the following group : 4-chloro-N-[(5-{[4-(hexylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 3-Methoxy-N-{[5-({4-[(4-trifluoromethylbenzyl)amino]piperidin-l-yl}sulfonyl)thien- 2-yl]methyl jbenzamide 4-chloro-N-[(5-{ [4-(l,3-thiazol-2-ylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N- [(5- { [4-(heptylamino)piperidin- 1 -yl] sulfonyl } thien-2- yl)methyl]benzamide 4-chloro-N-[(5-{[4-(pentylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N-[(5-{ [4-(butylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 4-chloro-N-[(5-{ [4-(dodecylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N- { [5-( { 4-[(2-cyclohexylethyl)amino]piperi din- 1 -yl } sulfonyl)thien-2- yljmethyl }benzamide 4-chloro-N-{[5-({4-[(cyclohexylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N-( { 5- [(4- { [( 1R)- 1 -cyclohexylethyl] amino } piperidin- l-yl)sulfonyl]thien-2- yl }methyl)benzamide N-{ [5-({4-[(lR,2R,4S)-bicyclo[2.2. l]hept-2-ylamino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl } -4-chlorobenzamide 4-chloro-N-{[5-({4-[(2-propoxyethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl }benzamide N- { [5-({ 4-[( 1 -adamantylmethyl)amino]piperidin- 1 -yl } sulfonyl)thien-2-yl]methyl } -4- chlorobenzamide 4-chloro-N-{ [5-({4-[(2-pyridin-2-ylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl }benzamide 4-chloro-N-{[5-({4-[(2-piperidin-l-ylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 4-chloro-N-{[5-({4-[(2-ethylhexyl)amino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl }benzamide 4-chloro-N-( { 5- [(4- { [3 -( lH-imidazol- 1 -yl)propyl] amino } piperidin- 1 - yl)sulfonyl]thien-2-yl}methyl)benzamide 4-chloro-N-[(5-{[4-(octylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]benzamide N-[(5-{ [4-(heptylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 3-methoxy-N-[(5-{[4-(octylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 3 -methoxy-N- [(5- { [4-(pentylamino)piperidin- 1 -yl] sulfonyl } thien-2- yl)methyl]benzamide N-[(5-{[4-(butylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-[(5-{ [4-(dodecylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-{ [5-({4-[(2-cyclohexylethyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N-( { 5- [(4- { [(1R)- 1 -cyclohexylethyl] amino jpiperi din- l-yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide N-{ [5-({4-[(lR,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl }-3-methoxybenzamide 3-methoxy-N-{ [5-({4-[(2-propoxyethyl)amino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl }benzamide N- { [5-( { 4- [( 1 -adamantylmethyl)amino]piperidin- 1 -yl } sulf onyl)thien-2-yl]methyl } -3- methoxybenzamide N- { [5 -( { 4- [(3 ,3 -diethoxypropyl)amino] piperidin- 1 -yl } sulf onyl)thien-2-yl] methyl } -3 - methoxybenzamide 3-methoxy-N-{ [5-({4-[(3-morpholin-4-ylpropyl)amino]piperidin-l-yl } sulfonyl)thien- 2-yl]methyl jbenzamide 3-methoxy-N- { [5-({ 4- [(2-pyridin-2-ylethyl)amino]piperidin- 1 -yl } sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-{ [5-({4-[(2-piperidin-l-ylethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl Jbenzamide N-{ [5-({4-[(2-ethylhexyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N-({5-[(4-{[3-(lH-imidazol-l-yl)propyl]amino}piperidin-l-yl)sulfonyl]thien-2- yl }methyl)-3 -methoxybenzamide N-[(5-{ [4-(hexylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-[(5-{ [4-(heptylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 3-methoxy-N- [(5- { [4-(octylamino)azepan- 1 -yl] sulf onyl }thien-2-yl)methyl]benzamide 3-methoxy-N- [(5- { [4-(pentylamino)azepan- 1 -yl] sulf onyl } thien-2- yl)methyl]benzamide N-[(5-{[4-(butylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-3-methoxybenzamide N-[(5-{ [4-(dodecylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-{ [5-({4-[(2-cyclohexylethyl)amino]azepan-l-yl }sulfonyl)thien-2-yl]methyl }-3- methoxybenzamide N-( { 5-[(4- { [(1R)- 1 -cyclohexylethyl] amino } azepan- 1 -yl)sulf onyl]thien-2-yl } methyl)- 3-methoxybenzamide N-{ [5-({4-[(lR,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]azepan-l-yl}sulfonyl)thien-2- yl]methyl } -3-methoxybenzamide 3-methoxy-N- { [5-({ 4-[(2-propoxyethyl)amino] azepan- 1 -yl } sulf onyl)thien-2- yl]methyl Jbenzamide N-{ [5-({4-[(cyclohexylmethyl)amino]azepan-l-yl } sulf onyl)thien-2-yl] methyl }-3- methoxybenzamide N- { [5-( { 4- [( 1 -adamantylmethyl)amino] azepan- 1 -yl } sulf onyl)thien-2-yl] methyl } -3 - methoxybenzamide 3 -methoxy-N- { [5 -( { 4- [(3 -morpholin-4-ylpropyl)amino] azepan- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide 3-methoxy-N-{[5-({4-[(2-pyridin-2-ylethyl)amino]azepan-l-yl}sulfonyl)thien-2- yljmethyl Jbenzamide 3-methoxy-N- { [5 -( { 4- [(2-piperidin- 1 -ylethyl)amino] azepan- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide N- { [5-( { 4-[(2-ethylhexyl)amino] azepan- 1 -yl } sulf onyl)thien-2-yl]methyl } -3- methoxybenzamide N-({5-[(4-{ [3-(lH-imidazol-l-yl)propyl]arnino}azepan-l-yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide 4-chloro-N-[(5-{[4-(heptylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 4-chloro-N-[(5-{[4-(octylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]benzamide 4-chloro-N-[(5-{ [4-(pentylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]benzamide N-[(5-{ [4-(butylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-4-chlorobenzamide 4-chloro-N-[(5-{ [4-(dodecylamino)azepan-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N- { [5-({ 4- [(2-cyclohexylethyl)amino] azepan- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide N-{[5-({4-[(lR,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]azepan-l-yl}sulfonyl)thien-2- yl]methyl } -4-chlorobenzamide 4-chloro-N- { [5 -( { 4- [(2-propoxyethyl)amino] azepan- 1 -yl } sulf onyl)thien-2- yl]methyl } benzamide 4-chloro-N- { [5-( { 4- [(2-ethylhexyl)amino] azepan- 1 -yl } sulfonyl)thien-2- yljmethyl }benzamide 4-chloro-N-[(5-{[4-(hexylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]benzamide N-[(5-{ [4-(hexylamino)azepan-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 3-methoxy-N-[(5-{[4-({2-[3-(trifluoromethyl)phenyl]ethyl}amino)piperidin-l- yl]sulfonyl}thien-2-yl)methyl]benzamide 3-methoxy-N-({5-[(4-{[2-(4-methylphenyl)ethyl]amino}piperidin-l-yl)sulfonyl]thien- 2-yl } methyl)benzamide 3 -methoxy-N-( { 5 - [(4- { [( 1 S ,2R)-2-phenylcyclopropyl] amino } piperidin- 1 - yl)sulfonyl]thien-2-yl}methyl)benzamide 3-methoxy-N-{[5-({4-[(l-naphthylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3 -methoxy-N- { [5 -( { 4- [(2-phenylpropyl)amino] piperidin- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide N-( { 5-[(4- { [2-(4-hydroxyphenyl)ethyl] amino }piperidin- 1 -yl)sulf onyl]thien-2- yl }methyl)-3-methoxybenzamide 3-methoxy-N-{ [5-({4-[(3-phenylpropyl)amino]piperidin-l-yl } sulfonyl)thien-2- yl]methyl }benzamide N-{[5-({4-[(2,3-dihydroxypropyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}- 3-methoxybenzamide N- { [5-( { 4-[(2-hydroxyethyl)amino]piperidin- 1 -yl } sulf onyl)thien-2-yl]methyl } -3- methoxybenzamide 3-methoxy-N-[(5-{[4-(nonylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 3-methoxy-N-[(5-{ [4-(decylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 3-methoxy-N-[(5-{ [4-(ethylamino)piperidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide N- { [5 -( { 4- [(2- [ 1 , 1 -biphenyl] -4-ylethyl)amino]piperidin- 1 -yl } sulf onyl)thien-2- yl]methyl } -3 -methoxybenzamide N- { [5 -( { 4- [( [ 1 , 1 -biphenyl] -3 -ylmethyl)amino] piperidin- 1 -yl } sulf onyl)thien-2- yljmethyl } -3 -methoxybenzamide 3-methoxy-N- { [5-( { 4- [(2-thien-2-ylethyl)amino]piperidin- 1 -yl } sulfonyl)thien-2- yljmethyl }benzamide 3-methoxy-N-[(5-{[4-({4-[(trifluoromethyl)sulfonyl]benzyl}amino)piperidin-l- yl]sulfonyl}thien-2-yl)methyl]benz amide 3 -methoxy-N- {[5-({4- [(quinolin-4-ylmethyl)amino]piperidin- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide N- { [5 -( { 4- [([ 1 , 1 -biphenyl] -4-ylmethyl)amino] - 1 -piperidinyl } sulf onyl)-2- thienyl] methyl } -3 -methoxybenzamide 4-chloro-N- { [5 -( { 4- [(2- { [(trifluoromethyl)sulf onyl] amino } ethyl)amino] - 1 - piperidinyl } sulfonyl)-2-thienyl]methyl }benzamide 4-chloro-N-[(5-{[4-(propylamino)-l-piperidinyl]sulfonyl}-2- thienyl)methyl]benzamide 4-chloro-N- [(5- { [4-( { 4- [(trifluoromethyl)sulf onyljbenzyl } amino)- 1 - piperidinyl]sulfonyl}-2-thienyl)methyl]benzamide 4-chloro-N- { [5-( { 4-[(3 ,4-dihydroxybenzyl)amino]- 1 -piperidinyl } sulf onyl)-2- thienyl] methyl }benzamide methyl [{ l-[(5-{ [(4-chlorobenzoyl)amino]methyl}-2-thienyl)sulfonyl]-4- piperidinyl } (hexyl)amino] acetate tert-butyl [{ l-[(5-{ [(4-chlorobenzoyl)amino]methyl}-2-thienyl)sulfonyl]-4- piperidinyl } (hexyl)amino] acetate [{ l-[(5-{ [(4-chlorobenzoyl)amino]methyl}-2-thienyl)sulfonyl]-4- piperidinyl}(hexyl)amino] acetic acid N-[(5-{ [3-(heptylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 3-methoxy-N-[(5-{ [3-(octylamino)pyrrolidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 3 -methoxy-N- [(5 - { [3-(pentylamino)pyrrolidin- 1 -yl] sulfonyl } thien-2- yl)methyl]benz amide N-[(5-{ [3-(butylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N-[(5-{ [3-(dodecylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide N- { [5-( { 3- [(2-cyclohexylethyl)amino]pyrrolidin- 1 -yl } sulf onyl)thien-2-yl] methyl } -3- methoxybenzamide N-({5-[(3-{[(lR)-l-cyclohexylethyl]amino}pyrrolidin-l-yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide N-{[5-({3-[(lR,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]pyrrolidin-l-yl}sulfonyl)thien- 2-yl]methyl } -3 -methoxybenzamide 3-methoxy-N-{ [5-({3-[(2-propoxyethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{[5-({3-[(cyclohexylmethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N-{[5-({3-[(l-adamantylmethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide 3 -methoxy-N- { [5 -( { 3 -[(3 -morpholin-4-ylpropyl)amino]pyrrolidin- 1 - yl } sulfonyl)thien-2-yl] methyl } benzamide 3 -methoxy-N- { [5 -( { 3- [(2-pyridin-2-ylethyl)amino]pyrrolidin- 1 -yl } sulf onyl)thien-2- yl]methyl } benzamide 3-methoxy-N-{ [5-({ 3-[(2-piperidin-l-ylethyl)amino]pyrrolidin-l-yl } sulfonyl)thien-2- yl]methyl }benzamide N-{ [5-({ 3-[(2-ethylhexyl)amino]pyrrolidin-l-yl } sulfonyl)thien-2-yl]methyl }-3- methoxybenzamide N-[(5-{[3-(hexylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 4-chloro-N-[(5-{[3-(heptylamino)pyrrolidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide 4-chloro-N- [(5- { [3-(hexylamino)pyrrolidin- 1 -yl] sulfonyl } thien-2- yl)methyl]benzamide 4-chloro-N-[(5-{ [3-(pentylamino)pyrrolidin-l-yl]sulfonyl}thien-2- yl)methyl]benzamide N-[(5-{[3-(butylamino)pyrrolidin-l-yl]sulfonyl}thien-2-yl)methyl]-4- chlorobenz amide 4-chloro-N-{ [5-({3-[(2-cyclohexylethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{[5-({3-[(lR,2R,4S)-bicyclo[2.2.1]hept-2-ylamino]pyrrolidin-l-yl}sulfonyl)thien- 2-yl] methyl } -4-chlorobenzamide 4-chloro-N-({5-[(3-{[(l-hydroxycyclohexyl)methyl]amino}pyrrolidin-l- yl)sulfonyl]thien-2-yl}methyl)benzamide N-{[5-({3-[(l-adamantylmethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2-yl]methyl}-4- chlorobenzamide 4-chloro-N-{[5-({3-[(3-morpholin-4-ylpropyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl] methyl } benzamide 4-chloro-N-{[5-({3-[(2-pyridin-2-ylethyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yljmethyl }benzamide 4-chloro-N- { [5-( { 3- [(2-piperidin- l-ylethyl)amino]pyrrolidin- 1 -yl } sulfonyl)thien-2- yljmethyl } benzamide 4-chloro-N-{[5-({3-[(2-ethylhexyl)amino]pyrrolidin-l-yl}sulfonyl)thien-2- yl]methyl } benzamide 4-chloro-N- [(5- { [3-(octylamino)pyrrolidin-l-yl]sulfonyl }thien-2- yl)methyl]benzamide methyl (2S)-l-[(5-{ [(4-chlorobenzoyl)amino]methyl }-2-thienyl)sulfonyl]-4- (hexylamino)-2-pyrrolidinecarboxylate 3-methoxy-N-{ [5-({4-[(pentylamino)methyl]piperidin-l-yl } sulfonyl)thien-2- yljmethyl Jbenzamide N-{ [5-({4-[2-(butylamino)ethyl]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N-{[5-({4-[(4-butylanilino)methyl]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide 4-chloro-N- { [5-( { 4- [hexyl (methyl)amino]piperidin- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide 4-chloro-N-{[5-({4-[(cyclohexylmethyl)(hexyl)amino]piperidin-l-yl}sulfonyl)thien- 2-yl]methyl }benzamide N-{[5-({4-[benzyl(hexyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-4- chlorobenzamide 4-chloro-N-{[5-({4-[hexyl(pyridin-3-ylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl jbenzamide 4-chloro-N- { [5-( { 4-[hexyl(pyridin-4-ylmethyl)amino]piperidin- 1 -yl } sulfonyl)thien-2- yljmethyl jbenzamide 4-chloro-N-{[5-({4-[hexyl(pyridin-2-ylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl jbenzamide N-{[5-({4-[butyl(hexyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-4- chlorobenzamide 4-chloro-N-{[5-({4-[hexyl(3-phenylpropyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl jbenzamide 4-chloro-N- { [5-( { 4- [hexyl(2-phenylethyl)amino]piperidin- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide N-{[5-({4-[[(5-bromo-2-furyl)methyl](hexyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl } -4-chlorobenzamide 3-methoxy-N-({5-[(4-{methyl[4-(trifluoromethyl)benzyl]amino}-l- piperidinyl)sulfonyl]-2-thienyl}methyl)benzamide 4-chloro-N- { [5-( { 4- [(3-chlorobenzyl)amino]piperidin- 1 -yl } sulfonyl)thien-2- yl]methyl }benzamide 3 -methoxy-N-( { 5 - [(4- { [4-(trifluoromethyl)benzyl] amino } piperidin- 1 - yl)sulfonyl]thien-2-yl}methyl)benzamide 3-methoxy-N-{ [5-({4-[(3-methylbenzyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N- { [5-( { 4-[(4-propylbenzyl)amino]piperidin- 1 -yl } sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-({5-[(4-{[3-(trifluoromethyl)benzyl]amino}piperidin-l- yl)sulfonyl]thien-2-yl}methyl)benzamide 3-methoxy-N-( { 5-[(4- { [4-(trifluoromethoxy)benzyl] amino } piperidin- 1 - yl)sulfonyl]thien-2-yl}methyl)benzamide N-({ 5- [(4- { [4-(difluoromethoxy)benzyl] amino }piperi din- 1 -yl)sulfonyl]thien-2- yl }methyl)-3-methoxybenzamide 3-methoxy-N-{[5-({4-[(2,3,4,5,6-pentamethylbenzyl)amino]piperidin-l- yl } sulf onyl)thien-2-yl] methyl }benzamide 3-methoxy-N-{[5-({4-[(4-propoxybenzyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide N-{ [5-({4-[(4-butoxybenzyl)amino]piperidin-l-yl }sulfonyl)thien-2-yl]methyl }-3- methoxybenzamide 3-methoxy-N-{[5-({4-[(4-methoxybenzyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl } benzamide 3-methoxy-N-{[5-({4-[(pyridin-4-ylmethyl)amino]piperidin-l-yl}sulfonyl)thien-2- yljmethyl }benzamide 3-methoxy-N- { [5-( { 4-[(pyridin-2-ylmethyl)amino]piperidin- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide 3-methoxy-N- { [5-({ 4- [(pyridin-3-ylmethyl)amino]piperidin- 1 -yl } sulf onyl)thien-2- yl]methyl }benzamide N-{[5-({4-[(4-tert-butylbenzyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide N-{[5-({4-[(3-ethoxybenzyl)amino]piperidin-l-yl}sulfonyl)thien-2-yl]methyl}-3- methoxybenzamide 3-methoxy-N-{[5-({4-[(4-phenoxybenzyl)amino]piperidin-l-yl}sulfonyl)thien-2- yl]methyl }benzamide 3-methoxy-N-[(5-{[4-({4-[(trifluoromethyl)sulfanyl]benzyl}amino)piperidin-l- yl]sulfonyl}thien-2-yl)methyl]benzamide 3-methoxy-N-({5-[(4-{[4-(methylsulfonyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl }methyl)benzamide N-( { 5- [(4- { [3 ,5-bis(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2- thienyl}methyl)-3-methoxybenzamide N-({5-[(4-{[2,5-bis(trifluoromethyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl}methyl)-3-methoxybenzamide N-({5-[(4-{ [4-(ethylsulfanyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl}methyl)-3-methoxybenzamide 3-methoxy-N-[(5-{[4-({3-[(trifluoromethyl)sulfanyl]benzyl}amino)-l- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide N-({5-[(4-{ [(2,2-difluoro-l,3-benzodioxol-5-yl)methyl]amino}-l- piperidinyl)sulfonyl]-2-thienyl}methyl)-3-methoxybenzamide N-{[5-({4-[(4-iodobenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide N-( { 5- [(4- { [4-(benzyloxy)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2-thienyl } methyl)- 3-methoxybenzamide N- { [5-({ 4- [(mesitylmethyl)amino] - 1 -piperidinyl } sulf onyl)-2-thienyl]methyl } -3- methoxybenzamide N- { [5-( { 4- [(4-chlorobenzyl)amino] - 1 -piperidinyl } sulf onyl)-2-thienyl] methyl } -3- methoxybenzamide N-{[5-({4-[(4-ethylbenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide 3-methoxy-N- { [5-({ 4- [(4-pentylbenzyl)amino] - 1 -piperidinyl } sulfonyl)-2- thienyl]methyl }benzamide 3-methoxy-N-[(5-{ [4-({ l-[4-(trifluoromethyl)phenyl]ethyl}amino)-l- piperidinyl]sulfonyl}-2-thienyl)methyl]benzamide 3-methoxy-N- { [5-( { 4- [(4-methylbenzyl)amino]- 1 -piperidinyl } sulfonyl)-2- thienyl]methyl }benzamide N-{[5-({4-[(4-butylbenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide N-{ [5-({4-[(4-isopropylbenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide N-{[5-({4-[(4-isobutylbenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-3- methoxybenzamide N-({5-[(4-{[(l-hydroxy-llambda~5~-pyridin-4-yl)methyl]amino}-l- piperidinyl)sulf onyl] -2-thienyl } methyl)-3 -methoxybenzamide N-{[5-({4-[(2,3-dihydro-l,4-benzodioxin-6-ylmethyl)amino]-l-piperidinyl}sulfonyl)- 2-thienyl]methyl}-3-methoxybenzamide N- { [5-( { 4-[(2,3-dihydro- 1 -benzofuran-5-ylmethyl)amino] - 1 -piperidinyl } sulfonyl)-2- thienyl]methyl}-3-methoxybenzamide 4-chloro-N- { [5 -( { 4- [(4-propylbenzyl)amino] - 1 -piperidinyl } sulf onyl)-2- thienyl]methyl }benzamide 4-chloro-N-( { 5- [(4- { [4-(trifluoromethoxy)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2- thienyl }methyl)benzamide 4-chloro-N-( { 5-[(4- { [4-(difluoromethoxy)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2- thienyl }methyl)benzamide 4-chloro-N- { [5-( { 4-[(4-propoxybenzyl)amino]- 1 -piperidinyl } sulfonyl)-2- thienyl]methyl }benzamide N-{[5-({4-[(4-butoxybenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-4- chlorobenzamide 4-chloro-N-{ [5-({4-[(4-quinolinylmethyl)amino]-l-piperidinyl}sulfonyl)-2- thienyl]methyl } benzamide N-{[5-({4-[(4-tert-butylbenzyl)amino]-l-piperidinyl}sulfonyl)-2-thienyl]methyl}-4- chlorobenzamide 4-chloro-N-{ [5-({4-[(4-phenoxybenzyl)amino]-l-piperidinyl}sulfonyl)-2- thienyl]methyl }benzamide 4-chloro-N-[(5- { [4-( { 4-[(trifluoromethyl)sulf anyl]benzyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N-({5-[(4-{[4-(trifluoromethyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl }methyl)benzamide 3-methoxy-N-({5-[(4-{[2-(trifluoromethyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl }methyl)benzamide 3-methoxy-N-[(5-{ [4-({[6-(trifluoromethyl)-3-pyridinyl]methyl}amino)-l- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide N-[(5-{ [4-(benzylamino)-l-piperidinyl]sulfonyl}-2-thienyl)methyl]-3- methoxybenzamide 3-methoxy-N-[(5- { [4-( { 1 - [4-(trifluoromethyl)phenyl]propyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 3-methoxy-N-[(5- { [4-({ 1 -methyl- 1 - [4-(trifluoromethyl)phenyl] ethyl } amino)- 1 - piperidinyl]sulfonyl}-2-thienyl)methyl]benzamide 4-chloro-N-[(5-{ [4-({ l-[4-(trifluoromethyl)phenyl]ethyl}amino)-l- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N-[(5- { [4-( { 1 -methyl- 1 -[4-(trifluoromethyl)phenyl]ethyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N-[(5-{ [2-({ [4-(trifluoromethyl)benzyl] amino} methyl)- 1- pyrrolidinyl] sulfonyl } -2-thienyl)methyl]benzamide 4-chloro-N-[(5-{ [(3R)-3-({ [4- (trifluoromethyl)benzyl] amino } methyl)pyrrolidinyl] sulfonyl } -2- thienyl)methyl]benzamide 4-chloro-N-( { 5 - [(3 - { [4-(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2- thienyl }methyl)benzamide 4-chloro-N-{ [5-({ 3-[(hexylamino)methyl]-l-piperidinyl }sulfonyl)-2- thienyl]methyl }benzamide 4-chloro-N-({5-[(3-{[4-(trifluoromethyl)benzyl]amino}-l-pyrrolidinyl)sulfonyl]-2- thienyl }methyl)benzamide 4-chloro-N-{[5-({(3R)-3-[(hexylamino)methyl]pyrrolidinyl}sulfonyl)-2- thienyl]methyl }benzamide 4-chloro-N-[(5-{ [3-({ [4-(trifluoromethyl)benzyl]amino}methyl)-l- piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide 2-oxo-N-( { 5- [(4- { [4-(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2- thienyl }methyl)-l ,2-dihydro-3-pyridinecarboxamide N-[(5-{ [4-(hexylamino)-l-piperidinyl]sulfonyl}-2-thienyl)methyl]-2-oxo-l,2-dihydro- 3-pyridinecarboxamide N-[(5-{ [4-(hexylamino)-l-piperidinyl]sulfonyl}-2-thienyl)methyl]-2- hydroxybenzamide 2-hydroxy-N-({5-[(4-{[4-(trifluoromethyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl } methyl)benzamide N- [(5- { [4-(hexylamino)- 1 -piperidinyl] sulfonyl } -2-thienyl)methyl]-2-thioxo- 1 ,2- dihydro-3 -pyridinecarboxamide 2-thioxo-N-({5-[(4-{ [4-(trifluoromethyl)benzyl]amino}-l-piperidinyl)sulfonyl]-2- thienyl }methyl)- 1 ,2-dihydro-3-pyridinecarboxamide N- [(5- { [4-(butylamino)- 1 -piperidinyl] sulfonyl } -2-thienyl)methyl] -2-oxo- 1 ,2-dihydro- 3-pyridinecarboxamide N-( { 5- [(4- { ethyl [4-(trifluoromethyl)benzyl] amino } - 1 -piperidinyl)sulf onyl] -2- thienyl}methyl)-3-methoxybenzamide 4-chloro-N-[(5- { [4-( { imino [4-(trifluoromethyl)phenyl]methyl } amino)- 1 - piperidinyl] sulfonyl } -2-thienyl)methyl]benzamide l-[(5-{[(4-chlorobenzoyl)amino]methyl}-2-thienyl)sulfonyl]-4-(hexylamino)proline ethyl 2-{ [4-(hexylamino)piperidin- 1-yl] sulfonyl} -5- { [(3- methoxybenzoyl)amino]methyl}thiophene-3-carboxylate N- { [5- { [4-(hexylamino)piperidin- 1 -yl] sulfonyl } -4-(trimethylsilyl)thien-2-yl] methyl } - 3-methoxybenzamide N-({ 5-{ [4-(hexylamino)piperidin-l-yl]sulfonyl }-4-[hydroxy(phenyl)methyl]thien-2- yl }methyl)-3-methoxybenzamide 5-[(3-Methoxy-benzoylamino)-methyl]-2-[4-(4-trifluoromethyl-benzylamino)- piperidine-l-sulfonyl]-thiophene-3-carboxylic acid ethyl ester N-[(4-chloro-5-{[4-(hexylamino)piperidin-l-yl]sulfonyl}thien-2-yl)methyl]-3- methoxybenzamide 11. A sulfonamide derivative according to any of the preceding claims for use as a medicament. 12. Use of a sulfonamide derivative according to any of claims 1-10 for the preparation of a medicament for the treatment of a neuronal disorder selected from epilepsy, Alzheimer's disease, Huntington's disease, Parkinson's disease, retinal diseases, spinal cord injury, Multiple Sclerosis, head trauma and ischemia, an auto-immune disease selected from inflammatory bowel disease (IBD), rheumatoid arthritis, asthma, septic shock, transplant rejection, a cancer selected from breast-, colorectal-, pancreatic, ovarian, prostate, testicular, hepatic, kidney, lung cancer, a cardiovascular disease including stroke, arterosclerosis, myocor- dial infarction, myocordial reperfusion injury and an ischemic condition includ- ing heart, renal, kidney and brain reperfusion injuries, renal failure. 13. Use of a sulfonamide derivative according to to claim 12, for the modulation of the JNK pathway. 14. Use according to claim 13 for the treatment or prevention of disorders associated with the abnormal expression or activity of JNK. 15. Use according to claim 14 for the treatment or prevention of disorders associated with abnormal expression or activity of JNK2 and/or JNK3. 16. A pharmaceutical composition containing at least one sulfonamide derivative according to any of the claims 1 to 10 and a pharmaceutically acceptable carrier, diluent or excipient thereof. 17. Process for the preparation of a sulfonamide derivative according to any of claims 1 to 10, whereby a sulfonamide of formula (XIX) (χ|χ) wherein Ar 1 , Ar 2 , X, R 1 , R 2 and n are as above defined and Y is a pyrrolidine-3- one or a piperidine 4-one, is subjected to a reductive amination using an amine H 2 N-R 3 with R 3 being as above defined. 18. Process for the preparation of a sulfonamide derivative according to any of claims 1 to 10, wherein a sulfonamide of formula (XIX) 1 1 whereby Ar , Ar , X, R , R and n are as above defined and Y is a pyrrolidine-3- amine or a piperidine 4-amine, is reacted with an aldehyde R -CHO of the formula (Xa) with R 3 being as above defined. 19. Sulfonamide compounds of formula (XIX) wherein Ar 1 and Ar 2 are independently from each other aryl or heteroaryl, X is O or S; R 1 is hydrogen or a -Cg-alkyl group, n is an integer from 0 to 5, and Y is a pyrrolidine-3-one, a piperidine 4-one, pyrrolidine-3 -amine or a piperidine 4-amine.

Inventors: ARKINSTALL STEPHEN, BIAMONTE MARCO, CAMPS MONTSERRAT, CHURCH DENNIS, GOTTELAND JEAN-PIERRE, HALAZY SERGE, RUECKLE THOMAS, ARKINSTALL, STEPHEN, BIAMONTE, MARCO, CAMPS, MONTSERRAT, CHURCH, DENNIS, GOTTELAND, JEAN-PIERRE, HALAZY, SERGE, RUECKLE, THOMAS
Applicants: APPLIED RESEARCH SYSTEMS, ARKINSTALL STEPHEN, BIAMONTE MARCO, CAMPS MONTSERRAT, CHURCH DENNIS, GOTTELAND JEAN PIERRE, HALAZY SERGE, RUECKLE THOMAS, APPLIED RESEARCH SYSTEMS ARS HOLDING N.V., ARKINSTALL, STEPHEN, BIAMONTE, MARCO, CAMPS, MONTSERRAT, CHURCH, DENNIS, GOTTELAND, JEAN-PIERRE, HALAZY, SERGE, RUECKLE, THOMAS
Application year: 2001
Main classification: C07D409
IPC codes: A61K31, A61P1, A61P9, A61P11, A61P13, A61P19, A61P25, A61P27, A61P29, A61P35, A61P37, A61P43, C07D333, C07D409, C07D413