Natural-Phytotherapic composition based on hydroglyceric extracts for aerosol therapy

Abstract: A natural-phytotherapic composition based on hydroglyceric extracts for aerosol therapy, made in the following proportions, referred to 100 g of composition: hydroglyceric extract of propolis 0.5 to 20 g; hydroglyceric extract of helychrysum top 0.5 to 10 g; hydroglyceric extract of ginkgo biloba leaves 0.5 to 10 g; hydroglyceric extract of blackcurrant buds 1 to 20 g; eucalyptol 0.005 g; natural flavours 0.005 g; essential oil of tea pant 0.005 g; thyme essential oil 0.005 g; grapefruit seed extract 0.020 g; polysorbate 80 0.20 g; sodium chloride (Italian Official Pharmacopoeia) 0.9 g; purified water: the balance to 100 g.

Description: The present invention relates to a natural-phytotherapic composition based on hydroglyceric extracts for aerosol therapy. More particularly, the invention relates to a natural-phytotherapic composition based on hydroglyceric extracts for treating diseases of the respiratory tract, the composition being formulated so as to be administered in spray form through apparatuses for aerosol therapy. Inflammation of respiratory tract is indicated by symptoms like mucous hypersecretion, oedema, catarrh, cough, throat ache, difficulty in breathing, often accompanied by fever, in turn caused by bacterial, viral or mycotic infections. Conventionally, cortisone-based, non-steroid anti-inflammatory, fluidifying and antibiotic drugs are used for treating the above inflammation. Yet taking such drugs may have contraindications because of possible side effects, allergic reactions or intolerance of the drug by the patient. For treating the above mentioned diseases of the respiratory tract use of natural compositions is therefore suitable, which compositions allow dispensing with taking synthetic drugs or, at least, alloe reducing the dosage so as to overcome said drawbacks. There are known since a long time the therapeutic effects of extracts of medicinal plants such as: propolis, having antibacterial, antiviral, anti-inflammatory, antimycotic, immuno-stimulating, antioxidant, local anaesthetic and cicatrising effects; helychrysum, which has fluidifying and expectorant effects; ginkgo biloba, which has anti-oedema and anti-bronchoconstrictive effects; blackcurrant, which has anti-inflammatory, anti-reactive and diuretic effects; eucalyptol, which has balsamic mucolytic expectorant and antiseptic effects; thyme, which has bronchial antispastic effects. Compositions containing propolis with some essential oils and/or exudates or transudates of plants for therapeutic use are also known. An example of such compositions is known from European patent application EP 0 747 057. Yet, use of phytotherapic combinations of hydroglyceric extracts to be administered through apparatuses for aerosol therapy is not known. Thus, it is an object of the present invention to provide a natural-phytotherapic composition for treating diseases of the respiratory tract, adapted to be administered through apparatuses for aerosol therapy. The above and other objects of the present invention are attained through the composition based on hydroglyceric extracts, as defined in the appended claims. Advantageously, thanks to the aerosol administration, a prolonged absorption of the active principles contained in the natural-phytotherapic composition is obtained, to perform the following pharmacological actions: fluidifying, anti-inflammatory, antibacterial, antibiotic and local anaesthetic actions. Moreover, the composition according to the invention can be employed as an alternative to synthetic fluidifying and mucolytic drugs and can be advantageously associated with cortisone-based or antibiotic drugs, thereby allowing a reduction of the daily dosage of the latter, with clear advantages concerning tolerability and side effect reduction in patients. Further features and advantages of the invention will become more apparent from the following description of a preferred but not exclusive embodiment thereof. Preferably, the natural-phytotherapic composition according to the invention is obtained by mixing, in combination or in the alternative, a defined amount of: hydroglyceric extract of propolis; hydroglyceric extract of helychrysum top; hydroglyceric extract of ginkgo biloba leaves; hydroglyceric extract of blackcurrant buds; with eucalyptol, natural flavours (mint, menthol, anethol), tea plant essential oil, thyme essential oil, grapefruit seed extract, polysorbate 80 and sodium chloride in purified water. The formulation of the hydroglyceric extracts according to the invention is specifically intended to obtain an effective spraying of the composition by means of the apparatus for aerosol therapy, so as to allow a beneficial absorption of the active principles contained in the composition itself. The natural-phytotherapic composition of hydroglyceric extracts is obtained by mixing the components in the following proportions, referred to 100 g of composition: hydroglyceric extract of propolis 0.5 to 20 g; hydroglyceric extract of helychrysum top 0.5 to 10 g; hydroglyceric extract of ginkgo biloba leaves 0.5 to 10 g; hydroglyceric extract of blackcurrant buds 1 to 20 g; eucalyptol 0.005 g; natural flavours 0.005 g; essential oil of tea pant 0.005 g; thyme essential oil 0.005 g; grapefruit seed extract 0.020 g; polysorbate 80 0.20 g; sodium chloride (Italian Official Pharmacopoeia) 0.9 g; purified water: the balance to 100 g. Example A particularly effective composition has been made with the following proportions, referred to 100 g of composition: hydroglyceric extract of propolis 2 g; hydroglyceric extract of helychrysum top 2 g; hydroglyceric extract of ginkgo biloba leaves 1 g; hydroglyceric extract of blackcurrant buds 5 g; eucalyptol 0.005 g; natural flavours 0.005 g; tea plant essential oil 0.005 g; thyme essential oil 0.005 g; grapefruit seed extract 0.020 g; polysorbate 80 0.20 g; sodium chloride (Italian Official Pharmacopoeia) 0.9 g; purified water 88.86 g. The above composition has proved to be particularly effective and exhibited clear fluidifying, expectorant, anti-cough, anti-inflammatory, antibiotic and local anaesthetic actions.

Claims: A natural-phytotherapic composition based on hydroglyceric extracts for aerosol therapy, characterised in that it comprises, referred to 100 g of composition: hydroglyceric extract (extractum hydroglycericum) of propolis 0.5 to 20 g; hydroglyceric extract of helychrysum top 0.5 to 10 g; hydroglyceric extract of ginkgo biloba leaves 0.5 to 10 g; hydroglyceric extract of blackcurrant buds 1 to 20 g; eucalyptol 0.005 g; natural flavours 0.005 g; tea pant essential oil 0.005 g; thyme essential oil 0.005 g; grapefruit seed extract 0.020 g; polysorbate 80 0.20 g; sodium chloride (Italian Official Pharmacopoeia) 0.9 g; purified water: the balance to 100 g. A natural-phytotherapic composition according to claim 1, wherein said hydroglyceric extract of propolis is present in an amount of 2 g per 100 g composition. A natural-phytotherapic composition according to claim 1, wherein said hydroglyceric extract of helychrysum top is present in an amount of 2 g per 100 g composition. A natural-phytotherapic composition according to claim 1, wherein said hydroglyceric extract of ginkgo biloba leaves is present in an amount of 1 g per 100 g composition. A natural-phytotherapic composition according to claim 1, wherein said hydroglyceric extract of blackcurrant buds is present in an amount of 5 g per 100 g composition.

Inventors: BARBERINI STEFANO, BARBERINI, STEFANO
Applicants: DOCTEUR NATURE SRL
Application year: 2001
Main classification: A61K35
IPC codes: A61K36