OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS

Abstract: The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharma-ceutical compositions containing the compounds of the present invention as anti-microbials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

Description: OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS FIELD OF THE INVENTION The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention 1 also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis. Mycobacterium avium and Mycobacterium spp. BACKGROUND OF THE INVENTION Increasing antibacterial resistance in Gram positive bacteria has presented a formidable treatment problem. The enterococci, although traditionally non virulent pathogens, have been shown, when associated with Vancomycin resistance, to have an attributable mortality of approximately 40%. Staphylococcus aureus, the traditional pathogen of post operative wounds, has been resistant to Penicillin due to production of penicillinases. This resistance was overcome by the development of various penicillinase stable β lactams. But the pathogen responded by synthesizing a modified target penicillin binding protein- 2' leading to less affinity for β lactam antibiotics and a phenotype known as Methicillin Resistant S. aureus (MRS A). These strains, till recently were susceptible to Vancomycin, which inspite of its various drawbacks, has become the drug of choice for MRSA infections. Streptococcus pneumoniae is a major pathogen causing pneumonia, sinusitis and meningitis. Until very recently it was highly susceptible to penicillin. Recently though, different PBP 2' strains with different susceptibility to penicillin have been reported from across the globe. Oxazolidinones are a new class of synthetic antimicrobial agents which kill gram positive pathogens by inhibiting a very early stage of protein synthesis. Oxazolidinones inhibit the formation of ribosomal initiation complex involving 30S and 50S ribosomes leading to prevention of initiation complex formation. Due to their novel mechanism of action, these compounds are active against pathogens resistant to other clinically useful antibiotics. WO93/23384 application discloses pheny loxazolidinones containing a substituted diazine moiety and their uses as antimicrobials. WO93/09103 application discloses substituted aryl and heteroaryl- phenyl- oxazolidinones useful as antibacterial agents WO90/02744 application discloses 5-indolinyl-5β-amidomethyloxazolidinones, 3-(fused ring substituted) phenyl-5β-amidomethyloxazolidinones which are useful as antibacterial agents. European Patent Publication 352,781 discloses phenyl and pyridyl substituted phenyl oxazolidinones. European Patent Application 312,000 discloses phenylmethyl and pyridinylmethyl substituted phenyl oxazolidinones. U.S. Patent No. 5,254,577 discloses nitrogen heteroaromatic rings attached to phenyloxazolidinone. U.S. Patents No. 5,547,950 and 5,700,799 also disclose the phenyl piperazinyl oxazolidinones. Other references disclosing various phenyloxazolidinones include U.S. Patents No. 4,801,600 and 4,921,869; Gregory W.A., et al, J.Med.Chem., 32, 1673-81 (1989); Gregory W.A., et al, J.Med.Chem., 33, 2569-78 (1990); Wang C, et al, Tetrahedron, 45, 1323-26 (1989); Brittelli, et al, J.Med. Chem., 35, 1156 (1992); and Bio-organic and Medicinal Chemistry Letters, 9, pp. 2679-2684, 1999. SUMMARY OF THE INVENTION The objective of this invention is to synthesize, identify and profile oxazolidinone molecules which have good activity against multiply resistant gram positive pathogens like MRSA, VRE and PRSP. Some of these molecules have activity against MDR-TB and MAI strains, while others have significant activity against important anaerobic bacteria. The compounds of the present invention are related by their substituted phenyloxazolidinone ring structure in the compounds disclosed to the publications described above except that the subject compounds have a diazine moiety attached to the phenyloxazolidinone which is further substituted by heterocyclic, aryl, substituted aryl, heteroaroamatic ring therefore the compounds are unique and have superior antibacterial activity. Another object of the present invention is to provide processes for the novel phenyloxazolidinones derivatives that exhibit significantly greater antibacterial activity, than available with the present compounds against multiply resistant gram positive pathogens like MRSA, RE and PRSP against MDR-TB and MAI strains, in order to provide safe and effective treatment of bacterial infections. In order to achieve the above-mentioned objectives and in accordance with the purpose of the invention as embodied and broadly described herein, there is provided a process for the synthesis of novel phenyloxazolidinone derivatives represented by Formula I FORMULA I wherein T is five to seven membered heterocyclic ring, aryl, substituted aryl, bound to the ring C with a linker w, preferred forms of T are selected from aryl and five membered heteroaryl which are further substituted by a group represented by R, wherein R is selected from the group consisting of-CN, COR 5 ,COOR 5 , N(R 6 ,R 7 ), CON (Re, R 7 ), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH = N-OR 10 , -C=CH-R 5 , wherein R 5 is selected from H, optionally substituted Cι-Cι 2j alkyl, C 3 -ι 2 , cycloalkyl, aryl, heteroaryl, R 6 and R 7 , are independently selected from H, optionally substituted Cι- 12 alkyl, C 3 -12 cycloalkyl, Cι- 6 alkoxy; R 8 and R are independently selected from H, C 5 - 6 alkyl, F, CI, Br, C 1 - 12 alkyl substituted with one or more of F, CI, Br, I, OR 5 , SRi, N(Rό,R ) wherein R 5 is selected from H, C 1 - 12 alkyl, C 3 _ι 2 cycloalkyl, Cι. 6 aikoxy, Cι_ 6 alkyl substituted with one or more F, CI, Br, I or OH and Re and R 7 are the same as defined earlier, R 5 is selected from H, optionally substituted C5.12 alkyl, C1-12 alkyl, C3-12 cycloalkyl, Cι- 6 alkoxy, C1- 6 alkyl, aryl, heteroaryl, n is an integer in the range from 0 to 3; X is CH, CH-S, CH-O and N; Y and Z are independently selected from hydrogen, C 1 6 alkyl, C 3 _ 12 and cycloalkyl C Q 3 bridging groups; U and V are independently selected from optionally substituted C 1 6 alkyl, F, CI, Br, C j 12 alkyl substituted with one or more of F, CI, Br, I, preferably U and V are hydrogen or fluoro; is selected from the group CH 2 , CO, CH 2 NH, -NHCH 2 , -CH 2 NHCH 2 , -CH 2 -N (Rπ) CH 2 -, CH 2 ( Rπ) N -, CH ( R π ), S, CH 2 ( CO), NH wherein R π is optionally substituted C 2 alkyl, C 3 _ 12 cycloalkyl, C 1 6 alkoxy, C 1 6 alkyl, aryl, heteroaryl; and, Ri is selected from the group consisting of - NHC(=O)R 2 wherein R 2 is hydrogen, C u alkyl, C 3 _ 12 cycloalkyl, C 1 6 alkoxy, C 1 6 alkyl substituted with one or more of F, CI, Br, I or OH, N(R 3 , R 4 ), -NR 2 C(=S) R 3 , -NR 2 C(=S)SR 3 wherein R 2 is the same as defined above, R3,Rι are independently selected from hydrogen, C. u alkyl, C 3 12 cycloalkyl, C 1 6 alkoxy, C χ _ 6 alkyl substituted with one or more of F, CI, Br, I or OH. Preferred compounds of Formula I have Ri as acetamide and the most preferred compounds in this series would be prepared as the optically pure enantiomers having the (S)-configuration according to the Cahn-Ingold-Prelog notation at C 5 of the oxazolidi- none ring. The (S)-enantiomer of this series of compounds is preferred since it has two times more antibacterial activity than the corresponding racemic compound. The scope of the individual isomers and mixture of enantiomers of the structural Formula I are also covered in this invention. Still more preferred compounds of the Formula I containing D ring as furanyl, thienyl and pyrrolyl ring systems and further substituted by substitutions Q and P is represented by Formula II FORMULA II wherein U and V are independently selected from optionally substituted C 1 6 alkyl, F, CI, Br, C j _ 12 alkyl substituted with one or more of F, CI, Br, I, preferably U and N are hydrogen or fluoro; X is CH, CH-S, CH-O and Ν; Y and Z are independently selected from hydrogen, C 1 6 alkyl, C 3 _ 12 and cycloalkyl C 0 3 bridging groups; and, W is selected from the group CH 2 , CO, CH 2 ΝH, -NHCH 2 , -CH 2 NHCH 2 , -CH 2 -N (Rπ) CH 2 -, CH 2 ( R π ) N -, CH ( Rπ), S, CH 2 ( CO), NH wherein R n is optionally substituted C 2 alkyl, C 3 _ 12 cycloalkyl, C 1 6 alkoxy, C 1 6 alkyl, aryl, heteroaryl. Preferred compounds of Formula II of this invention are those when Q and P are independently selected from the group consisting of -CN, COR 5 , COOR 5 , N (R 6 , R7 ), CON (R g ^), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH=N-ORι 0 , C=CH-R 5 , wherein R 5 is selected from the group consisting of H, optionally substituted C χ 12 alkyl, C 3 _ 12 cycloalkyl, aryl, or heteroaryl; Re, R 7 are independently selected from H, optionally substituted C 2 alkyl, C 3 _ 12 cycloalkyl, C j _ 6 alkoxy, Rg, R and are independently selected from the group consisting of H, C j _ 6 alkyl,F, CI, Br, C j _ 12 alkyl substituted with one or more of F, CI, Br, I, OR_ι, R 7 ), Rι 0 = H, optionally substituted. C 1 12 alkyl, C 3 _ 12 cycloalkyl, C l g alkoxy, C χ _ g alkyl, aryl, heteroaryl except W= (CO), Q and P=H. In the more preferred compounds represented by Formula π ring C may be 6-8 membered in size and the larger rings may have either two or three carbons between each nitrogen atom, for example: The ring C may be bridged to form a bicyclic system as shown below: " When ring C is optionally substituted at positions Y and Z with alkyl groups, cycloalkyl groups, fluoro group, carboxylic and conesponding esters, amides, substituted alkyls or bridging alkyl groups are as shown below: When ring C is 6 membered in size and X is -CH-(NHR), the following rings are preferred ones wherein Ri i is the same as defined earlier. In addition to the above, ring C also includes the following structures: Still more prefened compounds of Formula II when M = Sulphur is represented by Formula III FORMULA III wherein U and V are independently selected from optionally substituted C 1 6 alkyl, F, CI, Br, C χ _ 12 alkyl substituted with one or more of F, CI, Br, I, preferably U and N are hydrogen or fluoro; X is CH, CH-S, CH-O and Ν; Y and Z are independently selected from hydrogen, C 1 6 alkyl, C 3 _ 12 and cycloalkyl C 0 _ 3 bridging groups; is selected from the group CH 2 , CO, CH 2 ΝH, -NHCH 2 , -CH 2 NHCH 2 , -CH 2 -N (Rπ) CH 2 -, CH 2 ( R π ) N -, CH ( R n ), S, CH 2 ( CO), NH wherein R π is optionally substituted C j _ 12 alkyl, C 3 _ 12 cycloalkyl, C j _ 6 alkoxy, C χ 6 alkyl, aryl, heteroaryl; and, Q and P are independently selected from the group consisting of -CN, COR 5 , COOR 5 , N (R 6 , R7 ), CON (R^R.), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH=N-ORιo, C=CH-R 5 , wherein R 5 is selected from the group consisting of H, optionally substituted C j _ 12 alkyl, C 3 _ 12 cycloalkyl, aryl, or heteroaryl; R & R 7 are independently selected from H, optionally substituted C _ 12 alkyl, C 3 _ 12 cycloalkyl, C j _ 6 alkoxy, R 8 , R 9 and are independently selected from the group consisting of H, C j _ 6 alkyl,F, CI, Br, C 2 alkyl substituted with one or more of F, CI, Br, I, OR t , SR 4 ,N(R 6 , R 7 ), Rio = H, optionally substituted C j _ 12 alkyl, C 3 _ 12 cycloalkyl, C 1 6 alkoxy, C χ 6 alkyl, aryl, heteroaryl except W= (CO), Q and P=H. More prefened Q, P substitutions are nitro, aldehydes and halides. Preferably W is selected from the groups consisting of CH 2 C(=O), C(=0)- C(=O), CH 2 NH, -NHCH 2 , -CH 2 NHCH 2 , -CH 2 -N(CH3)CH 2 -, CH 2 ( CH 3 )N -, CH ( CH 3 ), S and CH 2 ( C=O), -NH. The most prefened compounds of Formula HI are as follows: -(S)-N-[[3-[4-[4-(N-methyl-N-2-thienyl(5-nitro)methyl)aminopiperidine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl] methyl]acetamide -(S)-N[[3-[3-Fluoro-4-[N-l[4-{2-(2-thienyl)dicarbonyl}]piperazinyl]phenyl]2- oxo-5-oxazolidinyl] methyl]acetamide -(S)-N[[3-[3-Fluoro-4-[N-l[4-(5-nitro-2-thienoyl)]piperazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl] acetamide hydrochloride Still more prefened compounds of Formula II is represented by Formula IN FORMULA IV containing oxygen atom in ring D of Formula II, wherein U and V are independently selected from optionally substituted C 1 6 alkyl, F, CI, Br, C j _ 12 alkyl substituted with one or more of F, CI, Br, I, preferably U and N are hydrogen or fluoro; X is CH, CH-S, CH-O and Ν; Y and Z are independently selected from hydrogen, C χ _ 6 alkyl, C 3 _ 12 and cycloalkyl C 0 _ 3 bridging groups; W is selected from the group CH 2 , CO, CH 2 ΝH, -NHCH,, -CH 2 NHCH 2 , -CH,-N (Rπ) CH 2 -, CH 2 ( R n ) N -, CH ( R π ), S, CH 2 ( CO), NH wherein R π is optionally substituted C 1 12 alkyl, C 3 _ 12 cycloalkyl, C χ 6 alkoxy, C 1 6 alkyl, aryl, heteroaryl; and, Q and P are independently selected from the group consisting of -CN, COR 5 , COOR 5 , N (R 6 , R 7 ), CON (R ff Ei j ), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH=N-ORιo, C=CH-R 5 , wherein R 5 is selected from the group consisting of H, optionally substituted C j _ 12 alkyl, C 3 _ χ2 cycloalkyl, aryl, or heteroaryl; R & R 7 are independently selected from H, optionally substituted C j _ 12 alkyl, C 3 _ 12 cycloalkyl, C j _ 6 alkoxy, R 8 , R and are independently selected from the group consisting of H, C j 6 alkyljF, CI, Br, C } alkyl substituted with one or more of F, CI, Br, I, OR 4 , R 7 ), Rio = H, optionally substituted C 1 12 alkyl, C 3 _ 12 cycloalkyl, C l g alkoxy, C χ _ 6 alkyl, aryl, heteroaryl except W= (CO), Q and P=H. More prefened Q and P substitutions are nitro, aldehydes and halides. Preferably W is selected from the groups consisting of CH, C(=O), C(=O)- C(=O), CH 2 NH, -NHCH 2 , -CH 2 NHCH 2 , -CH 2 -N(CH 3 )CH 2 -, CH 2 ( CH 3 )N -, CH ( CH 3 ), S, CH 2 ( C=O), and -NH. The most prefened compounds of Formula IN are as follows : -(S)-Ν-[[3-Fluoro-4-[Ν-l[4-(5-nitro-2-furoyl)piperazinyl]phenyl]-2-oxo-5- oxazolidinyljmethyl] acetamide. -(S)-N-[[3-[3-fluoro-4-|Η-l-[4-{2-furyl-(5-nitro)methyl}]piperazmyl]ρhenyl]-2- oxo-5-oxazohdinyl] methyl]acetamide. -(S)-N-[[3-[4-[4-(N-methyl-N-(5-mfro-2-furoyl)aminopiperidine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl Jmethyl] acetamide. -(S)-N-[[3-[4-[4-(Η-methyl-N-2-furyl(5-nitro)methyl)aminopiperidine-l-yl]-3- fluorophenyl] -2-oxo-oxazolidin-5 -yl] methyl] acetamide. The compounds of the present invention are useful as antimicrobial agents, effective against a number of human and veterinary pathogens, particularly aerobic Gram-positive bacteria, including multiply-antibiotic resistant staphylococci and streptococci, as well as anaerobic organisms such as Mycobacterium tuberculosis and other mycobacterium species. For preparing pharmaceutical compositions from the compounds described by this invention, inert, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, dispersible granules, capsules, cachets, suppositories, and ointments. A solid carrier can be one or more substances which may also act as diluents, flavouring agents, solubilizers, lubricants, suspending agents, binders, or tablets disintegrating agents; it can also be as finely divided solid which is in admixture with the finely divided active compound. For the preparation of tablets, the active compound is mixed with carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain from about 5 to about 70 percent of the active ingredient. Suitable solid carriers are lactose, pectin, dextrin, starch, gelatin, tragacanth, low melting wax, cocoa butter, and the like. The term "preparation" is intended to include the formulation of the active compound with encapsulating material as carrier providing a capsule in which the active component (with or without other carriers) is surrounded by carrier, which is thus in association with it. Similarly, capsules can be used as solid dosage forms suitable for oral administration. Liquid form preparations include solutions, suspensions, and emulsions. As an example may be mentioned water or water-propylene glycol solutions for parenteral injection. Such solutions are prepared so as to be acceptable to biological systems (isotonicity, pH, etc.). Liquid preparations can also be formulated in solution in aqueous polyethylene glycol solution. Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavours, stabilizing, and thickening agents as desired. Aqueous suspension suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, i.e., natural or synthetic gums, resins, methyl cellulose, sodium carboxymethyl cellulose, and other well-known suspending agents. Ointment preparations contain heavy metal salts of a compound of Formula I with a physiologically acceptable carrier. The carrier is desirably a conventional water- dispersible hydrophilic or oil-in-water carrier, particularly a conventional semi-soft or cream-like water-dispersible or water soluble, oil-in-water emulsion infected surface with a minimum of discomfort. Suitable compositions may be prepared by merely incorporating or homogeneously admixing finely divided compounds with the hydrophilic carrier or base or ointment. Preferably, the pharmaceutical preparation is in unit dosage form. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete capsules, powders in vials or ampoules, and ointments capsule, cachet, tablet, gel, or cream itself or it can be the appropriate number of any of these packaged forms. The quantity of active compound in a unit dose of preparation may be varied or adjusted from less than 1 mg to 100 mg according to the particular application and the potency of the active ingredient. In therapeutic use as agents for treating bacterial infections the compounds utilized in the pharmaceutical method of this invention are administered at the initial dosage of about 3 mg to about 40 mg per kilogram daily. The dosages, however, may be varied depending upon the requirements of the patient and the compound being employed. Determination of the proper dosage for a particular situation is within the smaller dosages which are less than the optimum dose. Small increments until the optimum effect under the daily dosage may be divided and administered in portions during the day if desired. In order to achieve the above mentioned objects in accordance with the purpose of the invention as embodied and broadly described herein, there are provided process for the synthesis of compounds of Formulae I, II, III and IN. Pharmaceutically acceptable non-toxic acid addition salts of the compounds of the present invention of Formulae I, II, III and IN may be formed with inorganic or organic acids, by methods well known in the art. The present invention also includes within its scope prodrugs of the compounds of Formulae I, π, HI and IN. In general, such prodrugs will be functional derivatives of these compounds which readily get converted in vivo into defined compounds. Conventional procedures for the selection and preparation of suitable prodrugs are known. The invention also includes pharmaceutically acceptable salts, the enantiomers, diastereomers, Ν-oxides, prodrugs, metabolites in combination with pharmaceutically acceptable carrier and optionally included excipient. Other objects and advantages of the invention will be set forth in the description which follows, and in part will be apparent from the description, or may be learned by the practice of the invention. The objects and the advantages of the invention may be released and obtained by means of the mechanism and combination pointed out in the appended claims. DETAILED DESCRIPTION OF THE INVENTION The compounds of the present invention may be prepared by following the reaction sequences as depicted in the schemes defined below. Mainly five different amines of Formula V FORMULA V identified as five different cores, namely -(S)-N-[[3-[3-Fluoro-4-(N-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide (core I); -(S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-methyl]amino]-3-azabicyclo- [3.1.0]hexane]phenyl ]-2-oxo-5-oxazolidinyl]methyl]acetamide (core II); -(S)-N-[[3-[3-Fluoro[4-[3-(lα,5 α,6 α)-6-[N-methyl] amino methyl] -3 -azabi- cyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide (core III); -(S)-N-[[3-[4-[4-N-methylamino piperidin-l-yl]-3-fluorophenyl}-2-oxo-oxazolid- in-5-yl]methyl acetamide (core IV); and, -(S)-N-[[3-[3[Fluoro-4-(N-l-homopiperazinyl)phenyl]-2-oxo-5-oxazolidinyl]- methyl] acetamide (core V), were used for analoguing purposes. Key intermediate amines of Formula V for the analogue preparation were prepared from commercially available reagents wherein G in amines of Formula V is defined as NH, CH(NHR), -CH-CH 2 NHR wherein R is H, ethyl, methyl, isopropyl, acetyl, cyclopropyl, alkoxy, or acetyl and U, V, Y and Z are as defined for Formula II. Some amines of Formula V are afready known in the literature and are given by reference and if they have been made for the first time or by a different procedures or variation of known procedure they are described in detail in the experimental section. Optically pure amines of Formula V could be obtained either by one of a number of asymetric syntheses or alternatively by resolution from a racemic mixture by selective crystallization of a salt prepared, with an appropriate optically active acid such as dibenzoyl tartrate or 10-camphorsulfonic acid, followed by treatment with base to afford the optically pure amine. The compounds of the present invention represented by general Formula I may be prepared by the method of reaction in Scheme I: SCHEME-I FORMULA V FORMULA I In Scheme I, the heteroaromatic group with the conesponding appendage can be infroduced on the nitrogen atom of ring C of compounds of Formula V by one of the methods described below to given Formula I, wherein Rι is a suitable leaving group well known to one of ordinary skill in the art such as fluoro, chloro, bromo, SCH 3 , -SO 2 CH 3 , - SO2CF3 or OC 6 H 5 etc. and G in amines of Formula N is defined as ΝH, CH(ΝHRι 3 ), - CH-CH 2 NHRi 3 wherein R 1 3 is H, ethyl, methyl, isopropyl,acetyl, cyclopropyl,, alkoxy or acetyl U, V, Y and Z are as defined for Formula I earlier. Amine of structure of Formula V is reacted with a heteroaromatic compound of Formula R-T-W-Rι 2 wherein R, T, W are the same as defined for Formula I earlier. For the preparation of compounds of Formula I when W is equal to CH conesponding aldehyde can be used through a process of reductive animation and is attached to amine of Formula V. Similarly, for the preparation of compound of Formula I wherein W is equal to C = O conesponding acid can be used and the amino of Formula V can be acylated through activated esters in the presence of condensing agents such as 1,3- dicyclohexylcarbodiimide (DCC) and l-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC). Other methods of acylation can also be employed. Alternatively, the compounds having carbonyl link can also be made by reacting heteroaromatic compound of the Formula VI FORMULA VI such as N- methyl pyrrole with the intermediate amine of Formula V in the presence of triphosgene or phosgene. Carbonyl linkers may also be introduced between heteroaromatic compound such as 3- bromothiophene and amine of Formula V with carbon monoxide and the catalyst such as Pd (PPh3) 2 Cl 2 . Extended chain pynoles having dicarbonyl linkers can also be obtained from treatment with oxalyl chloride and amine of the Formula V. The reduction of the carbonyl linkers using the standard reducing agents results in the formation of methylene linkers. Preparation of the compound of Formula I as represented by Formula II (where heterocycle is 5 membered ring) is accomplished as exemplified below by three methods A, B and C as shown in Scheme II: SCHEME- II FORMULA V FORMULA VI FORMULA II Method A: Amine of structure N is reacted with a heteroaromatic compound of Formula NI having Rι 2 as a suitable leaving group defined earlier for Scheme I. Q, P and M are as defined for Formula II. The reaction is done in a suitable solvent such as dimethylformamide, dimethylacetamide, ethanol or ethylene glycol at a suitable temperature in the range of - 70°C to 180°C to afford compounds of Formula I. The presence of a suitable base such as triethylamine, diisopropyl amine, potassium carbonate, sodium bicarbonate is useful in some cases to improve the yield of the reaction. Method B: Reductive alkylation of the amine intermediate of Formula V, with the conesponding heterocyclic aldehydes of the Formula VI, such as furaldehyde (Q, P = H, M=O; R12 is CHO) using known reducing agents well known to one of ordinary skill in the art such as sodium triacetoxyborohydride or sodium cyanoborohydride gave the products of Formula II wherein W=CH 2 as shown in the Scheme II. Method C : Acylation of intermediate amines of Formula V with heterocyclic acid of Formula VI, such as 2- furoic acid ( Q,P = H; M=O, Rι 2 =COOH) gave products of Formula II, wherein W=CO, as shown in the Scheme II wherein U, V, Y, Z, X, W, M, P, Q and R u are the same. -(S)-N[[3-[3-Fluoro-4-[N-l[4-(5-nitro-2-thienoyl)]piperazinyl]phenyl]2-oxo-5- oxazolidinyljmethyl] acetamide hydrochloride was prepared using this method. Alternatively, the compounds having carbonyl link can also be made by reacting heteroaromatic compound of the Formula VI such as N- methyl pyrrole with the intermediate amine of Formula V in the presence of triphosgene or phosgene. Carbonyl linkers may also be introduced between heteroaromatic compound such as 3- bromothiophene and amine of Formula V with carbon monoxide and the catalyst such as Pd ( PPh 3 ) 2 C1 2 . Extended chain pynoles having dicarbonyl linkers can also be obtained from treatment with oxalyl chloride and amine of the Formula V. The reduction of the carbonyl linkers using the standard reducing agents results in the formation of methylene linkers. SCHEME- III FORMULA VII 1- 5 STEPS FORMULA VIII The compounds prepared by Scheme I represented by Formula VII FORMULA VII were further used as starting compounds for further derivatisation as represented by Scheme III wherein U,V,Y,Z,X,W,P,Q, n and M are the same as defined earlier. The group Rι 4 was transformed in one to five steps into final compounds of Formula Nm FORMULA VIM wherein U,N,Y,Z, n, X,W,P and M are the same as defined earlier containing transformed group R15. In most cases the Rι 4 group in starting compounds were compounds containing Rι 4 as aldehyde and ketones. The following compounds are exemplified in Scheme- IIIA, ILIB and IIIC. SCHEME- R16= — CH 2 F 15 """CHjFj FORMULA XI (S)-N-[[3-[3-Fluoro-4-[N-l {2-futyl-[4-(5-hydroxymethyl)methyl}] piperazinyl]- 2-oxo-5-oxazolidinyl]methyl] acetamide represented by Formula X was prepared by reducing aldehyde of Formula IX with sodium borohydride. (S)-N-[[3-[3-fluoro-4-[N-l {2-furyl-[4-(5-fluoromethyl) methyl} ]piperazinyl]-2- oxo-5-oxazolidinyl]-methyl] acetamide of Formula XI (Rι 6 l= CH 2 F) was prepared by reacting (S)-N-[[3-[3-Fluoro-4-[N-l {2-furyl-[4-(5-hydroxymethyl)methyl}] piperazinyl]- 2-oxo-5-oxazolidinyl] methyl] acetamide by reacting Formula X with diethylamino sulfurtrifluoride. (S)-N-[[3-[3-fluoro-4-|Η-l {2-furyl-[4-(5-difluoromethyl) methyl} ]piperazinyl]-2- oxo-5-oxazolidinyl]-methyl]acetamide of Formula XI (Riβ = CH 2 F 2 ) was prepared by reacting (S)-N-[[3-Fluoro-4-[N-l[4-{2-ftιryl(5-formyl)methyl}]piperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl] acetamide of Formula IX with diethylamino sulfurtrifluoride as shown in Scheme IIIA. SCHEME-HI B FORMULA IX FORMULA Xπ (S)-N-[[3-Fluoro-4-[N-l [4- {2-furyl(5-formyl)methyl} ]piperazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl] acetamide of Formula IX was reacted with hydroxylamine and hydrazine hydrate to give (S)-N-[[3-[3-Fluoro-4-pST-l-[4-(2-furyl-(5-aldoxime)methyl}] piperazinyl] phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide of Formula XII (Ri7 = \= N - OH ) and (S)-N-[[3-[3-Fluoro-4[N-l-[4-{2-furyl-(5-hydrazone)- methyl}]-piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide of Formula XII (R 17 = NHN-NB J ) (S)-N-[[3-[3-Fluoro-4-|TN-l[4-{2-fiiryl(5-aldoxime(methyl-4-(N- carboxyaminophenyl acetate)methyl}]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]- acetamide of Formula XII (R = ^=N-O-C-NH-^^-CH 2 COOCH 3 ) was made starting o from (S)-N-[[3-[3-Fluoro-4-[N-l-[4-(2-furyl-(5-aldoxime)methyl}] piperazinyl] phenyl]- 2-oxo-5-oxazolidinyl]methyl]acetamide of Formula XII (Rι 7 = Xr^-o H ) atl( i reacting with isocyanate. (S)-N-[[3-[3-Fluoro-4-[N-l [4-{2-furyl(5-cyano)methyl}] piperazinyljphenyl] -2- oxo-5-oxazolidinyl]methyl]acetamide of Formula XII (Rι 7 = CN) was prepared from (S)- N-[[3-[3-Fluoro-4-[N-l [4-{2-furyl(5-aldoxime)methyl}]piperazinyl] phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide of Formula XII ( Rl 7 = ^=N-OH ) by the use of trifilic anhydride and triethylamine. (S)-N-[[3-Fluoro-4-[N-l[5-(l,3-dioxane)-2-fiιrylmethyl]ρiρerazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl] acetamide of Formula XII (R17 = — CH ^ ) was made o— ' using (S)-N-[[3-Fluoro-4-[N-l [4- {2-furyl(5-formyl)methyl}]piperazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl] acetamide of Formula IX with 1,3-propane diol and BF 3 etherate. SCHEME - III C FORMULA TX FORMULA Xm FORMULA XIV o R I I 18 NH, (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-carboxy)methyl}]piperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl] acetamide of Formula XIII was made using (S)-N-[[3- Fluoro-4-[N-l[4-{2-furyl(5-formyl)methyl}] piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]- methyl] acetamide of Formula IX by oxidation with Ag 2 O. [[3-Fluoro-4-p^-l[5-(formamido)-2-fijtrylmethyl]piperazinyl]phenyl]-2-oxo-5- o R = " oxazolidinyl]methyl] acetamide of Fonnula XIV 18 ^ C NH was made by reacting (S)-N-[[3-Fluoro-4-|Η-l[4-(2-furyl- (5-carboxyethyl)methyl)piperazinyl] phenyl]- 2-oxo- 5-oxazolidinyl]methyl] acetamide with aqueous ammonia. (S)-N-[[3-Fluoro-4-[N-l[5-(4-(tert butoxy carbonyl)amino piperidine)-2- furylmethyl]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula carboxy)methyl)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula XIII with thionyl chloride and 4-(tert butoxy carbonyl)amino piperidine. (S)-N - [ [3 -Fluoro-4- [N- 1 [5 -(morpholine- 1 -carbonyl)-2-furylmethyl]piperazinyl]- c. - phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula XIV RlB N O was made by reacting (S)-N-[[3-Fluoro-4-[N-l[4-(2-furyl-(5-carboxy)methyl)- piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula XIII with morpholine in the presence of oxalyl chloride. The transformations effected are described in the experimental section. In the above synthetic methods where specific acids, bases, solvents, catalysts, oxidising agents, reducing agents etc. are mentioned, it is to be understood that the other acids, bases, solvents, catalysts, oxidising agents, reducing agents etc. may be used. Similarly, the reduction temperature and duration of the reaction may be adjusted according to the need. An illustrative list of particular compounds according to the invention and capable of being produced by the above mentioned schemes include: Compound No. Chemical Name 1. (S)-N-[[3-[3-Fluoro-4-[N-l-[4-(2-ftιroyl) piperazinyl]]phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide 2. (S)-N-[[3-[3-Fluoro-4-[N-l[4-{2-ftιryl(5-foπnyl)methyl}]ρiρerazinyl]phenyl]-2-oxo- 5 -oxazolidinyl]methyl] acetamide 3. (S)-N-[[3-Fluoro-4-I I-l[4-(2-furyl-(5-carboxyethyl)methyl)piperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl]acetamide 4. (S)-N-[[3-Fluoro-4-P^-l[4-(5-bromo-2-furoyl)]piperazinyl]phenyl]-2-oxo-5-oxazol- idinyl] methyl] acetamide 5. (S)-N-[[3-Fluoro-4-[N-l[4-(5-chloromethyl-2-furoyl)piperazinyl]phenyl]-2-oxo-5- oxazolidinyl]methyl] acetamide 6. (S)-N-[[3-Fluoro-4-pSf-l[4-(5-mfro-2-furoyl)piperazinyl]phenyl]-2-oxo-5-oxazol- idinyl] methyl]acetamide 7. (S)-N[[3-[3-Fluoro-4-[N-l [4- {2-(2-thienyl)dicarbonyl}]ρiρerazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl] acetamide 8. (S)-N[[3-[3-Fluoro-4-| -l[4-(3-furoyl)]piperazinyl]phenyl]2-oxo-5-oxazolidinyl]- methyl] acetamide 9. (S)-N[[3-[3-Fluoro-4-| [-l[4-{2-furyl(5-bromo)methyl}]ρiρerazinyl]ρhenyl ]2-oxo-5- oxazolidinyl]methyl]acetamide 10. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-chloro)methyl}]ρiρerazinyl]ρhenyl]2-oxo- 5 -oxazolidinyl]methyl] acetamide 11. (S)-N[[3-[3-Fluoro-4-[N-l [4-(2-fiiryhnethyl)]piperazinyl]phenyl]2-oxo-5- oxazolidinyl] methyl] acetamide 12. (S)-N-[[3-[3-Fluoro-4-[N-l[4-(2-thienyhnethyl)]ρiperazinyl]ρhenyl]-2-oxo-5-oxazol- idinyl]methyl] acetamide 13. (S)-N[[3-[3-Fluoro-4-[N-l[4-(2-thienylacetyl)]piperazinyl]ρhenyl]2-oxo-5-oxazolid- inyl] methyl] acetamide 14. (S)-N-[[3-[3-Fluoro-4-[N-l [4- {2-thienyl(4-bromo)methyl}]piperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl]acetamide 15. (S)-N-[[3-[3-fluoro-4-|^-l-[4-{2-furyl-(5-nitro)methyl}]piρerazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl]acetamide 16. Hydrochloric salt of (S)-N-[[3-Fluoro-4-|Η-l[4-{2-furyl(5-nitro)methyl}]piperazin- yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 17. Cifrate slat of (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-nitro)methyl}]piperazinyl]phen- yl]-2-oxo-5-oxazolidinyl]methyl]acetamide 18. (S)-N[[3-[3-Fluoro-4-[N-l [4-(2-pynolylmethyl)]piperazinyl]phenyl]2-oxo-5-oxazol- idinyl]methyl] acetamide 19. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(3-methyl)methyl}]ρiρerazinyl]phenyl]2-oxo- 5 -oxazolidinyl]methyl] acetamide 20. (S)-N[[3-[3-Fluoro-4-|Η-l[4-(3-furylmethyl)]ρiρerazinyl]phenyl]2-oxo-5-oxazol- idinyl] methyl] acetamide 21. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-methyl)methyl}]piperazinyl]phenyl]2-oxo- 5-oxazolidinyl]methyl]acetamide 22. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-pynole(l-methyl)methyl}]piperazinyl]phenyl]2-oxo- 5-oxazolidinyl]methyl]acetamide 23. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-nitro)methyl}]ρiρerazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl]acetamide 24. (S)-N[[3-[3-Fluoro-4-[N- 1 [4-[2-fiiryl {5-(N-thiomorpholinyl)methyl}methyl]ρiρeraz- inyl]phenyl]2-oxo-5-oxazolidinyl]methyl]acetamide 25. (S)-N[[3-[3-Fluoro-4-[N-l[4-[2-furyl{5-(N-morpholinyl)methyl}methyl]]piperazinyl] pheny l]2-oxo-5 -oxazolidinyl]methyl] acetamide 26. (S)-N-[[3-Fluoro-4-[N-l [4- {2-furyl(5-acetoxymethyl)methyl}]piperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl]acetamide 27. (S)-N-[[3-Fluoro-4-[N-l[4-{2-thienyl(5-bromo)methyl}]ρiρerazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl]acetamide 28. (S)-N-[[3-Fluoro-4-[N-l[4-(5-m^o-2-jtatylmethyl)piperazinyl]phenyl]-2-oxo-oxazol- idinyl]methyl]dichloroacetamide 29. (S)-N[[3-[3-Fluoro-4-[N-l[4-(5-nitro-2-thienoyl)]piperazinyl]phenyl]2-oxo-5-oxazol- idinyljmethyl] acetamide hydrochloride 30. (S)-N[[3-[3-Fluoro-4-[N-l[4-(2',2'-diρhenyl-2'-hydroxyacetyl)]piperazinyl]ρhen- yl]2-oxo-5-oxazolidinyl]methyl]acetamide 31. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6 )-6-[N-(5-nitro-2-furoyl)-N-methyl]amino]-3- azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 32. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(3-furoyl)-N-methyl]amino]-3-azabicyclo- [3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 33. (S)-N-[[3-[3-Fluoro[4-[3-(l ,5 ,6α)-6-[N-( 5-bromo -2-furoyl)-N-methyl] amino]-3- azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide 34. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(5-nitro-2-thienylmethyl)-N-methyl]- amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 35. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-|^-(5-mtro-2-furylme l)-N-memyl]aπm 3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyljacetamide 36. (S)-N-[[3-[3-Fluoro[4-[3-(l α,5α,6α)-6-[N-(5-formyl-2-mrylmethyl)-N-methyl] amino-methyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]meth- yl] acetamide 37. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5 ,6α)-6-[N-(5-carboxyethyl-2-furylmethyl)-N-methyl] aminomethyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide 38. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(2-thiopheneacetyl)-N-methyl]amino- methyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 39. (S)-N-[[3-[3-Fluoro[4-[3-(l ,5α,6 )-6-[N-(5-nitro-2-thienyhnethyl)-N-methyl]- amino-methyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]meth- yl]acetamide 40. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-|^-(5-mtro-2-furyhnethyl)-N-methyl]amino- methyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 41. (S)-N-[[3-[4-[4-(N-methyl-N-2furyl(5formyl)methylaminopiperidine- 1 -yl]-3-fluoro- phenyl]-2-oxo-oxazolidin-5-yl ]methyl]acetamide 42. (S)-N-[[3-[4-[4-(N-methyl-N-(3,5-difluorobenzoyl)aminopiperidine-l-yl]-3-fluoro- phenyl]-2-oxo-oxazolidin-5-yl] methyl] acetamide 43. (S)-N-[[3-[4-[4-(N-methyl-N-(5-bromo-2-furoyl)aminoρiperidine-l-yl]-3-fluoro- phenyl]-2-oxo-oxazolidin-5-yl] methyl]acetamide 44. (S)-N-[[3-[4-[4-(N-methyl-N-(5-mfro-2-fiιroyl)aminopiperidine-l-yl]-3-fluoro- phenyl]-2-oxo-oxazolidin-5-yl ]methyl] acetamide 45. (S)-N-[[3-[4-[4-(N-methyl-N-3- furoyl)aminopiperidine-l-yl]-3-fluorophenyl]-2-oxo- oxazolidin-5-yl ]methyl]acetamide 46. (S)-N- {3-[4-[4-(N-methyl, N-2-furoyl)aminopiperidine-l-yl]-3-fluorophenyl]-2-oxo- oxazolidin-5 -yl methyl] acetamide 47. (S)-N- {3-[4-[4-(N-methyl,2-thiopheneacetyl)aminopiperidine-l -yl]-3-fluorophenyl]- 2-oxo oxazolidin-5-yl methyl]acetamide 48. (S)-N-[[3-[4-[4-(N-methyl-N-2furylmethyl) aminopiρeridine-l-yl]-3-fluoroρhenyl]-2- oxo-oxazolidin-5-yl ]methyl] acetamide 49. (S)-N-[[3-[4-[4-(N-methyl-N-3-furyl)aminopiperidine-l-yl]-3-fluorophenyl]-2-oxo- oxazolidin-5-yl] methyl] acetamide 50. (S)-N-[[3-[4-[4-(N-methyl-N-2-furyl(5-nitro)methyl)aminoρiρeridine-l-yl]-3-fluoro- phenyl]-2-oxo-oxazolidin-5-yl] methyl]acetamide 51. (S)-N-[[3-[4-[4-(N-methyl-N-2-thienyl(5-nitro)methyl)anιinopiρeridine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl] methyl]acetamide 52. (S)-N-[[3-[4-[4-(TSf-methyl-N-2-thienylmethyl)aminopiperidine-l-yl]-3-fluoro- phenyl]-2-oxo-oxazolidin-5-yl jmethyl] acetamide 53. (S)-N-[[3-[4-[4-( -methyl-N-(5-methyl-2-thienylmethyl)aminopiρeridine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl] methyl]acetamide 54. (S)-N-{3-[4-[4-(N-methyl,2-(5-bromo)thienylmethyl)aminopiperidine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl methyl]acetamide 55. (S)-N[[3-[3-Fluoro-4-| f-l[4-{2-furyl(5-formyl)methyl}]homoρiperazinyl]phenyl]2- oxo-5-oxazolidinyl]methyl]acetamide 56. (S)-N[[3-[3-Fluoro-4-[N-l[4-(2-thienylacetyl)]homopiperazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl]acetamide 57. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-nitro)methyl}]homopiperazinyl]phenyl]2- oxo-5-oxazolidinyl]methyl]acetamide 58. (S)-N[[3-[3-Fluoro-4-^-l[4-(3-furyhnethyl)]homopiperazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl] acetamide 59. (S)-N-[[3-[3-fluoro-4-[N-l {2-furyl-[4-(5-difluoromethyl)methyl}]piperazinyl]-2-oxo- 5 -oxazolidinyl] -methyl] acetamide 60. (S)-N-[[3-[3-Fluoro-4-| r-l-[4-(2-furyl-(5-aldoxime)methyl}] piperazinyl] phenyl]-2- oxo-5 -oxazolidinyl]methyl] acetamide 61. (S)-N-[[3-[3-Fluoro-4-[N-l [4- {2-furyl(5-aldoxime(methyl-4-(N-carboxyaminophenyl acetate) methyl} ]piperazinyl]phenyl] -2-oxo-5 -oxazolidinyljmethyl] acetamide 62. (S)-N-[[3-[3-Fluoro-4[N-l-[4-{2-fiιryl-(5-hydrazone)-methyl}]-piperazinyl]-ρhenyl]- 2-oxo-5 -oxazolidinyl] -methyl] acetamide 63. (S)-N-[[3-[3-Fluoro-4-[N-l {2-furyl-[4-(5-hydroxymethyl)methyl}]piperazinyl]-2- oxo-5 -oxazolidinyl]methyl] acetamide 64. (S)-N-[[3-[3-Fluoro-4-[N-l[4-{2-furyl(5-cyano)methyl}] piρerazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl]acetamide 65. (S)-N-[[3-Fluoro-4-[N-l [4- {2-furyl(5-carboxy)methyl}]piperazinyl]phenyl]-2-oxo-5- oxazolidinyl]methyl] acetamide 66. (S)-N-[[3-FIuoro-4-[N- 1 [5-(l ,3-dioxane)-2-furylmethyl]piperazinyl]phenyl]-2-oxo-5- oxazolidinyl]methyl] acetamide 67. (S)-N-[[3-Fluoro-4-pST-l[5-(fomιamido)-2-furyjteethyl]piperazinyl]phenyl]-2-oxo-5- oxazolidinyl]methyl] acetamide 68. (S)-N- [ [3 -Fluoro-4- [N- 1 [5 -(mo holine- 1 -carbonyl)-2-fiιrylmethyl]piperazinyl]- phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide 69. (S)-N-[ [3 -Fluoro-4- [N-l [5 -(4-(tert butoxy carbonyl)amino piperidine)-2-furylmeth- yl]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide 70. (S)-N-[[3-Fluoro-4-[N-l[4-{(Z)-2-memoxyimino-2-(2-furyl)acetyl}]piperazinyl]- phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 71. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(2-thiopheneacetyl)-N-methyl]amino]-3- azabicyclo- [3.1.0]hexane]phenyl] -2-oxo-5 -oxazolidinyl]methyl] acetamide 72. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(5-formyl-2-furylmethyl)-N-methyl]- amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide 73. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(3-thienoyl)-N-methyl]amino]-3-aza- bicyclo[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyljacetamide 74. (S)-N-[[3-[3-fluoro-4-[N-l {2-furyl-[4-(5-fluoromethyl) methyl} ]piperazinyl]-2-oxo- 5-oxazolidinyl] -methyl] acetamide Pharmacological Testing The compounds of the invention display antibacterial activity when tested by the agar incorporation method. The following minimum inhibitory concentrations (μg/ml) were obtained for representative compounds of the invention which are given below in the following tables. GUIDE TO TABLE ABBREVIATIONS: 1) S.aureus ATCC 25923 —Staphylococus aureus ATCC 25923 2) MRSA 15187 —Methicillin Resistant Staphylococcus aureus 3) Ent. faecalis ATCC 29212 -Enterococcus faecalis ATCC 29212 4) Ent. faecium 6A — Enterococcus faecium 6A Van®,Ciprcf® 5) Strep, pne. ATCC 6303 Streptococcus pneumoniae ATCC 6303 6) Strep. pyog. ATCC 19615 —Streptococcus pyogenes 7) S. epidermidis - Staphylococcus epidermidis ATCC 12228 TABLE 1: MIC of compounds and standard antibiotics against important pathogens > SD TABLE 2 Summar of in vitro Activit MIC: TABLE 4 Changes in MIC under different conditions TABLE S Linezolid has 30% protein binding In vitro and in vivo activity against MRSA 562 The in vitro antibacterial activity of the compounds were demonstrated by the agar incorporation method (NCCLS M 7 and M 100-S8 documents). Briefly, the compounds were dissolved in DMSO and doubling dilution of the compounds were incorporated into Meuller Hilton agar before solidification. Inoculum was prepared by suspending 4 to 5 colonies into 5 ml of normal saline solution and adjusting the turbility to 0.5 Macfarland turbidity standard tables (1.5 x 10^ CFU/ml), after appropriate dilutions, 10^ CFU/spot was fransfered into the surface of dried plate and incubated for 18 hours (24 hours for MRSN studies). The concentration showing no growth of the inoculated culture was recorded as the MIC. Appropriate ATCC standard strains were simultaneously tested and result recorded only when the MIC's against standard antibiotics were within the acceptable range. The compounds of the present invention represented by general Formula I may be prepared by the method of reaction in Scheme I. Key intermediate amines of Formula V for the analogue preparation were prepared by the synthetic procedures described below from commercially available reagents. The compounds of Formula I were made by either Method A, B, or C. Amines already known in the literature are given by reference and if they have been made by a different procedures they are described in detail. Mainly five different amines of Formula V identified as five different cores namely (S)-N-[[3-[3-Fluoro-4-(N-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide (core I), (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-methyl]amino]-3-azabicyclo- [3.1.0]hexane]benzyl]-2-oxo-5-oxazolidinyl]methyl] acetamide (core II), (S)-N-[[3-[3-Fluoro[4-[3-(la,5a,6a)-6-[N-( 5-nifro-2-furylmethyl)-N-methyl] amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]- acetamide (core III), (S)-N-{3-[4-[4-N-methylaminopeperidin-l-yl]-3-fluorophenyl}-2-oxo-oxazol- idin-5-yl]methyl acetamide (core IV), and (S)-N-[[3-[3[Fluoro-4-(N-l-homopiperazinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide (core V) are shown in the examples given below. Most of the compounds were characterized using NMR, IR and were purified by chromatography. Crude products were subjected to column chromatographic purification using silica gel (100-200 or 60-120 mesh) as stationery phase. The examples mentioned below demonstrate the general synthetic procedure as well as the specific preparation for the preparation for the prefened compound. The examples are given to illustrate the details of the invention and should not be constrained to limit the scope of the present invention. EXAMPLE 1 Analogues of (S)-N-[β-[3-Fluoro-4-(N-piperazinyl)phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide(core I) The heteroaromatic group with the conesponding appendage can be introduced on the nitrogen atom of ring C of compounds of Formula I by one of the methods described below: Method-A: General procedure: Amine of structure of Formula N is reacted with a heteroaromatic compounds of Formula NI having conesponding R 12 appendages such as -CH 2 Rι 3 , -COR 13 or - CH(CH3)Ri 3 wherein R 13 is a suitable leaving group well known to one of ordinary skill in the art such as fluoro, chloro, bromo, SCH 3 , -SO 2 CH 3; -SO 2 CF 3 or OC 6 H 5 etc.. The reaction is done in a suitable solvent such as dimethylformamide, dimethylacetamide, ethanol or ethylene glycol at a suitable temperature in the range of -78°C to 180°C to afford compounds of Formula II. The presence of a suitable base such as triethylamine, diisopropyl amine, potassium carbonate, sodium bicarbonate is useful in some cases to improve the yield of the reaction. The following compounds were made following this method: Compound No. 01 (S)-N-[[3-[3-Fluoro-4-[N-l-[4-(2-furoyl) piperazinyl]]- phenyl]- 2-oxo-5-oxazolidinyl] methyl] acetamide (S)-N-[[3-[3-Fluoro-4-(N-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide prepared by the method given in U.S. Patent No. 5,700,799 (1.2g, 3.57 mmol) was dissolved in dry dimethyl formamide (35 ml). To this was added 1^00 3 (2.47g; 17.87 mmol) and fiiroyl chloride (0.56 g, 10.68 mmol). The reaction mixture was stined at 25°C for 5.0 hr. TLC of the reaction mixture was monitored. A faster moving spot was observed. Solvent was removed and the residue was dissolved in dichloromethane, washed with water, dried over sodium sulphate, and solvent was removed. The residue was digested with ether and filtered to yield 800 mg of white crystalline solid 225.5.-226.5°C δppm (CDCI 3 ) : 7.50-7.44 (m, 2H), 7.09-7.06 (m, 2H), 6.95-6.89 (m, IH) 6.50 (bs, IH) 4.76 (bs, IH), 4.05-3.19 (m, 9H), 3.09 (bs, 4H), 2.02 (s, 3H). Compound No. 02: (S)-N-[[3-[3-Fluoro-4-[N-l[4-{2-furyl(5-formyl)methyl}] piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl ] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l- piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-chloromethyl 2- furfuraldehyde using Method A. Compound No. 03: (S)-N-[[3-Fluoro-4-[N-l[4-(2-furyl- (5-carboxyethyl)methyl)- piperazinyl] phenyl]- 2-oxo-5-oxazolidinyI] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl] -2-oxo-5 -oxazolidinyl]methyl acetamide ethyl-5 -_chloromethyl)-2-furan- carboxylate using Method A. Compound No. 04: (S)-N-[[3-Fluoro-4-[N-l[4-(5-bromo-2-furoyI)]piperazinyI]- phenyl] -2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl] -2-0X0-5 -oxazolidinyl]methyl acetamide and 5-bromo-2-furoyl chloride using Method A. Compound No. 05: (S)-N-[[3-FIuoro-4-[N-l[4-(5-chloromethyl-2-furoyl)piper- azinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-chloromethyl-2-furoyl chloride using Method A. Compound No. 06: (S)-N-[[3-Fluoro-4-[N-l[4-(5-nitro-2-furoyl)piperazinyl]phen- yl] -2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-nitro -furoyl chloride using Method A. Compound No. 07: (S)-N[[3-[3-Fluoro-4-[N-l [4-{2-(2-thienyl)dicarbonyl}]- piperazinyl]phenyl]2-oxo-5-oxazolidinyl]methyl]acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 2-thiophenglyoxylyl chloride using Method A. δppm (CDC1 3 ): 7.84(m, 2H, Ar-H), 7.47(dd, IH, Ar-H), 7.2(m,lH, Ar-H), 7.07(d, IH, Ar-H), 6.92(t,lH, Ar-H), 5.98(t, IH, NH), 4.76(m,lH, CH), 4.0(t, IH, CH), 3.5-3.95 (m, 7H, CH 2 ), 3.15 (m, 2H, CH 2 ), 3.06 (m, 2H Cl 2 ), 2.02 (s, 3H, CH 3 ) Compound No. 08: (S)-N [ [3- [3-Fluoro-4-[N-l[4-(3-furoyl)] iperazinyl] phenyl] 2- oxo-5-oxazolidinyl] methyl] cetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 3 -furoyl chloride using Method A. δppm (CDCI 3 ) : 8.06(s, IH, Ar-H), 7.49(m, 2H, Ar-H), 7.09(d,lH,Ar-H), 6.76(t, IH, Ar-H), 6.57 (s,lH,Ar-H), 6.03(br s, IH, NH), 4.77 (m, IH, CH), 4.2- 3.5(m, 8H, CH 2 ), 3.06(m,4H, CH 2 ), 2.02(s, 3H,CH 3 ) Compound No. 09: (S)-N[[3-[3-FIuoro-4-[N-l[4-{2-furyl(5-bromo)methyl}]piper- azinyl]phenyl ]2-oxo-5-oxazolidinyI]methyl]acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-bromo-2-chloromethylfuran using Method A. δppm (CDC1 3 ): 7.47 (d, IH, Ar-H), 7.06 (d, IH, Ar-H), 6.91 (t, IH, Ar-H), 6.47 (d, IH, Ar-H), 6.32 (d,lH, Ar-H), 5.98 (t, IH, NH), 4.76 (m, IH, CH), 4.02 (t, IH, CH), 3.4-3.85 (m, 9H, CH2), 3.07 (m, 4H, CH 2 ), 2.02 (s, 3H, CH 3 ). Compound No. 10: (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-chloro)methyl}]- piperazinyl]phenyI]2-oxo-5-oxazoIidinyI]methylJacetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piper- azinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-chloro-2-chloromethyl- thiophene using Method A. δppm (CDCI 3 ) :7.42 (dd, IH, Ar-H), 7.05 (dd, IH, Ar-H), 6.92 (t, IH, Ar-H), 6.74 (d, 2H, Ar-H), 6.00 (m,lH, CH), 4.74 (m, IH, CH), 4.01 (t, IH, CH), 3.3-3.8 (m,5H, CH 2 ), 3.08 (m, 4H, CH 2 ), 2.66 (m 4H, CH 2 ) 2.01 (s, 3H, CH 3 ). Compound No. 11 : (S)-N[[3-[3-Fluoro-4-[N-l [4-(2-furylmethyI)] piperazinyl] - phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl] -2-oxo-5-oxazolidinyl]methyl acetamide and 2-chloromethylfuran using Method A. δppm (CDCI 3 ) :7.49 (m, 2H, Ar-H), 7.07 (d, IH, Ar-H), 6.91 (t, IH, Ar-H), 6.51 (d, IH, Ar-H), 6.4 (d,lH, Ar-H), 6.1 (t, IH, NH), 4.75 (m, IH, CH), 4.1-3.25 (m,10H, CH 2 ), 3.06 (m, 4H, CH 2 ), 2.03 (s, 3H, CH 3 ). Compound No. 12: (S)-N-[[3-[3-FIuoro-4-[N-l[4-(2-thienylmethyl)]piperazinyl]- phenyl]-2-oxo-5-oxazolidinyI] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 2-chloromethylthiophen using Method A. δppm (CDC1 3 ): 7.4 (m, IH, Ar-H), 6.94 (m, 5H, Ar-H), 6.08 (t, IH, NH), 4.71 (m, IH, CH), 4.1-3.4 (m, 6H, CH 2 ), 3.08 (m, 4H, CH 2 ), 2.73 (m,4H, CH 2 ), 1.98 (s, 3H, CH 3 ). Compound No. 13: (S)-N[[3-[3-Fluoro-4-[N-l[4-(2-thienylacetyl)]piperazinyl]- phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 2-thiophenacetyl chloride using Method A. δppm (CDCI3): 7.45 (dd, IH, Ar-H), 7.23 (d, IH, Ar-H), 7.07 (d, IH, Ar-H), 6.96 (m, 3H, Ar-H), 6.05 (t,lH, CH), 4.7 (m, IH, CH), 2.75-4.1 (m, 10H, CH 2 ), 3.01 (m,4H, CH 2 ), 2.03 (s, 3H, CH 3 ). Compound No. 14: (S)-N-[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(4-bromo)methyl}]- piperazinyl] phenyl] -2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piper- azinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 4-bromo-2-chloromethyl- thiophen using Method A. δppm (CDC1 3 ) :7.44 (dd, IH, Ar-H), 7.2-6.8 (m, 4H, Ar-H), 5.98 (t, IH, Ar- H), 4.76 (m, IH, CH), 4.02 (t, IH, CH), 3.85-3.35 (m,5H, CH 2 ), 3.1 (m, 4H, CH 2 ), 2.69 (m,4H, CH 2 ), 2.03 (s, 3H, CH 3 ). Method B: Compound No. 15: (S)-N-[[3-[3-fluoro-4-[N-l-[4-{2-furyl-(5-nitro)methyl}]piper- azinyl]phenyl]-2-oxo~5-oxazolidinyl] methyl] acetamide To a suspension of (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)phenyl]-2-oxo-5- oxazolidinyl]methyl acetamide (770 mg, 2.29 mmol) in dichloromethane or THF (40 ml) in a round bottom flask (100 ml) filled with guard tube, was added molecular sieves (4A) followed by 5-nitro-2-furfural (420 mg, 2.98 mmol). The reaction mixture was stined at 25°C for 1.5 hr. Sodium triacetoxy borohydride (1.93 g, 9.10 mmol) was then added to the reaction mixture. The whole reaction mixture was allowed to stir overnight at 25°C. TLC of the reaction mixture showed a faster moving spot compared to piperazine derivative. The reaction mixture was filtered through a Buckner funnel. It was washed with dichloromethane. Organic layer was washed with water, dried over sodium sulphate and solvent was removed to give crude product which was then purified by silica gel column using 2% methanol in chloroform as eluent to afford the title compound 417 mg of m.p. 104-105°C. δppm (CDCI 3 ) : 7.48 (d, IH), 7.34 (m, IH), 7.12 (d, IH), 6.98 (t, IH), 6.56 (d, IH), 6.07 (bs, IH), 4.81 (m, IH), 4.07 (t, IH), 3.69-3.53 (m, 5H) 3.16 (bs, 4H), 2.78 (bs, 4H), 2.07 (s, 3H). Compound No. 16: Hydrochloric salt of (S)-N-[[3-Fluoro-4-[N-l [4-{2-furyl(5- nitro) methyl}] piperazinyl] phenyl] -2-oxo-5-oxazolidinyl] methyl] acetamide (S)-N-[[3-Fluoro-4-[N-l[4{2-furyl-(5-nitro)methyl}]piperazinyl]-ρhenyl]-2- oxo-5-oxazolidinyl]-methyl]acetamide hydrochloride. To an ethanolic solution of (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl-(5-nitro)- methyl} jpiperazinyl] phenyl]-2-oxo-5-oxazlidinyl]methyl]acetamide (365 mg, 0.75 mmol in 7 ml of absolute ethanol) was added 0.30 ml of HCl in ethanol (2.6 N, 0.75 mmol) in cold (5°C) condition. The whole reaction mixture was stined at 5-10°C for 2.0 hr. No change in TLC was observed. Solvent was removed. The residue was digested with dichloromethane and the solid was crystallized from methanol isopropyl alcohol mixture to give the desired compound in 111 mg of 97% pure by HPLC. Mass : 461.8 (M+H+), 483.9 (M+Na+) Compound No. 17: Citrate salt of (S)-N-[I3-Fluoro-4~[N-l[4-{2-furyl(5-nitro)- methyl}]piperazinyl] phenyl]-2-oxo-5-oxazoIidinyl]methyl]acetamide Cifrate salt of Compound No. 15 was made according to the method described for Compound No. 16 by using citric acid in molar proportions. Compound No. 18: (S)-N[[3-[3-Fluoro-4-[N-l[4-(2-pyrrolylmethyl)]piperazinyl]- phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 2-pynolecarboxaldehyde using Method B. δppm (CDCI3): 8.76(br s, IH, NH), 7.38(d, IH, Ar-H). 7.04(d,lH, Ar-H), 6.91(t,lH,Ar-H), 6.77(s,lH,Ar-H), 6.11(m,3H, Ar-H, NH), 4.75 (m, IH, CH), 4.0(t,lH,CH), 3.8-3.5(m,5H, CH 2 ), 3.08(m,4H, CH2), 2.65(m,4H, CH2), 2.01(s,3H,CH3) Compound No. 19: (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(3-methyI)methyI}I- piperazinyl]phenyl]2-oxo-5-oxazolidinyl]methyl]acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piper- azinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 3-methyl-2-thiophen- carboxaldehyde using Method B. δppm (CDC1 3 ) : 7.4(d, IH, Ar-H), 7.15(d,lH, Ar-H), 7.03(d, lH,Ar-H), 6.92(t,lH, Ar-H), 6.79(d,lH,Ar-H), 6.07(t,lH, NH), 4.75(m, IH, CH), 3.98(t,lH, CH), 3.55-3.95(m,6H, CH2), 3.09(m,4H, CH2), 2.69(m, 3H, CH2), 2.22(s, 3H, CH3), 2.01(s, 3H, CH3) Compound No. 20: (S)-N[[3-[3-Fluoro-4-[N-l[4-(3- furyImethyl)]piperazinyl]phenyI]2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 3-furaldehyde using Method B. δppm (CDCI 3 ) : 7.42(m,3H, Ar-H), 7.04(d, IH, Ar-H), 6.92(t,lH,Ar-H), 6.43(s,lH, Ar-H), 6.0(t, IH, NH), 4.75(m,lH, CH), 4.01(t, IH, CH), 3.8- 3.5(m,3H,CH2), 3.47(s,2H,CH2), 3.1(m, 4H,CH2), 2.66 (m,4H, CH2), 2.01(s,3H, CH3) Compound No. 21 : (S)-N[[3-[3-Fluoro-4-[N-l [4-{2-thienyl(5-methyl)methyl}]- piperazinyl] phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-methyl-2-thiophencarbox- aldehyde using Method B. δppm (CDCI 3 ) : 7.4(dd, IH, Ar-H), 7.03(d, IH, Ar-H), 6.92(t, IH, Ar- H),6.71(d, IH, Ar-H),6.58(d, IH, Ar-H), 6.08(t, IH, NH), 4.75(m,lH,CH), 3.98(t,lH,CH), 3.8-3.5(m,5H, CH2), 3.07(m, 4H, CH2), 2.65(m,4H,CH2), 2.45(s,3H, CH3), 2.01(s,3H,CH3) Compound No. 22: (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-pyrrole(l-methyl)methyl}]- piperazinyl] phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and N-methyl-2-pyrrolecarboxalde- hyde using Method B. δppm (CDCI 3 ) :7.36(d, IH, Ar-H), 7.04(d, IH, Ar-H), 6.9(t,lH,Ar-H), 6.6(s, lH,Ar-H), 6.02(s, 3H, Ar-H, NH), 4.73(m, IH, CH), 4.0(t, IH, CH), 3.8-3.5(m,6H, CH2),3.49(s,2H, CH2), 3.02(m,4H, CH2), 2.58(m, 4H, CH2). 2.01(s, 3H, CH3) Compound No. 23: (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-nitro)methyl}]piper- azinyl] phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-nitro-2-thiophencarboxalde- hyde using Method B. δppm (CDCI 3 ) :7.80 (d, IH, Ar-H), 7.45 (dd, IH, Ar-H), 7.05 (d, IH, Ar-H), 6.91 (m, 2H, Ar-H), 6.07 (t,lH, NH), 4.76 (m, IH, CH), 4.2-3.5 (m, 6H, CH 2 ), 3.11 (m, 4H, CH 2 ), 2.73 (m, 4H, CH 2 ), 2.02 (s, 3H, CH 3 ). Compound No. 24: (S)-N[[3-[3-Fluoro-4-[N-l[4-[2-furyl{5-(N-thiomorpholinyl)- methyl}methyl]piperazinyl]phenyl]2-oxo-5-oxazolidinyl]methyl]acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-(N-thiomorpholinymethyl)-2- fixran- carboxaldehyde using Method B. δppm (CDCI 3 ): 7.45 (d, IH, Ar-H), 7.05 (d, IH, Ar-H), 6.9 (t, IH, Ar-H), 6.18 (d, 2H, Ar-H), 6.09 (m,lH, NH), 4.76 (m, IH, CH), 4.02 (t, IH, CH), 3.35-3.9 (m,7H, CH 2 ), 3.12 (m, 4H, CH 2 ), 2.75 (m, 11H, CH 2 ), 2.02 (s, 3H, CH 3 ). Compound No. 25:(S)-N[[3-[3-Fluoro-4-[N-l [4-[2-furyl{5-(N-morpholinyl)- methyl}methyl]]piperazinyl] phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-(N-moφholinylmethyl)2- furancarboxaldehyde using Method B. δppm (CDCI 3 ) :7.5-6.3 (m, 3H, Ar-H), 6.19 (d, 2H, Ar-H), 5.9 (m, IH, NH), 4.7 (m, IH, CH), 4.00 (t,lH, CH), 3.3-3.8 (m, 10H, CH 2 ), 3.09 (m, 4H, CH 2 ), 2.69 (m,4H, CH 2 ), 2.49 (m, 4H, CH 2 ), 2.01 (s, 3H, CH 3 ). Compound No. 26: (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyI(5-acetoxymethyl)- methyl}]piperazinyl] phenyI]-2-oxo-5-oxazoIidinyl]methyl]acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-(N-moφholinylmethyl)2- furylcarboxaldehyde using Method B. δppm (CDCI 3 ) :7.42 (dd, IH), 7.06 (dd, IH), 6.95 (d, IH), 6.35 (d, IH), 6.22 (d s,2H), 5.04 (s, 2H ), 4.02 ( bs, 4H, CH 2 ), 3.74 ( t, 1 H), 3.75- 3.6 (m, 3H), 3.64 (s, 3H) 3.10 ( bs, 4 H) 2.70 ( bs,4H ), 2.06 ( s, 3H), 2.02 (S, 3H). Compound No. 27: (S)-N-[[3-Fluoro-4-[N-l[4-{2-thienyl(5-bromo)methyl}]piper- azinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5- acetoxy methyl -2- furan - carboxaldehyde by using Method A. δppm (CDCI 3 ): 7.42 (dd, IH, Ar-H), 7.04 (d, IH, Ar-H), 6.88 (m, 2H, Ar-H), 6.69 (d, IH, Ar-H), 6.00 (t,lH, NH), 4.76 (m, IH, CH), 4.01 (t, IH, CH), 3.4-3.8 (m,5H, CH 2 ), 3.07 (m, 4H, CH 2 ), 2.67 (m, 4H, CH 2 ). Compound No. 28: (S)-N-[[3-Fluoro-4~[N-l [4-(5-nitro-2-furylmethyl)piperazin- yl] phenyl] - 2-oxo-5-oxazolidinyl] methyl] dichloroacetamide δppm (CDCI 3 ) : 7.41- 6.51(m, 6H), 5.96(s, IH), 4.81(m,lH), 4.06(t, IH), 3.77- 3.66(m,5H), 3.11- 2.71(m,8H) Method C: Compound No. 29: (S)-N[[3-[3-Fluoro-4-[N-l[4-(5-nitro-2-thienoyl)]piperazinyl]- phenyl]2-oxo-5-oxazolidinyl]methyl]acetamide hydrochloride To (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]- methyl] acetamide (1.14 mmol) in DMF (10 mL) cooled to 5°C, 5-nitro-2-thienoic acid (0.16g, 0.95 mmol), N-methylmoφholine (0.12g, 1.14 mmol) and 1- hydroxybenzotriazole (0.17 g, 1 mmol) were added and the reaction mixture was stined for 15 min. To it l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.18g, 0.95 mmol) was added and the reaction mixture was stined for 18 hrs allowing it to warm to R.T. Then the reaction mixture was diluted with 25 mL water and extracted with EtOAc (3x25 mL). The combined orgamc layers were washed with brine, dried over anhydrous sodium sulfate and evaporated in vacuo. The residue was purified by column chromatography (3% MeOH/CHCl 3 ) to yield 0.19g of product. This product was dissolved in dichloromethane (5 mL) and cooled to 5 C. To it 1 mL of satd. ethanolic-HCl solution was added and stined for 15 min. Then the reaction mixture was evaporated, co-evaporated with ether and dried in vacuo to yied 0.19 g of final product. δppm (DMSO) :8.2 (t,lH, Ar-H), 8.1(m,lH,Ar-H), 7.5(m,2H, Ar-H), 7.17(d,lH, Ar-H), 7.09(t,lH,Ar-H), 4.7(m,lH, CH), 4.08(t,lh, CH), 3.73(m,6H,CH2), 3.05 (m, 5H, CH 2 ), 1.83(s, 3H, CH3). Compound No. 30: (S)-N[[3-[3-Fluoro-4-[N-l[4-(2',2'- diphenyl-2' hydroxy acetyl)]piperazinyl]phenyl]- 2-oxo-5-oxazolidinyl]methyl]acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-piperazinyl)- phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide and 2,2 -diphenyl -2-hydroxy acetic acid using Method C. EXAMPLE 2 Analogues of (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-methyl] amino]-3-aza- bicyclo [3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyl] cetamide (Core II) The heteroaromatic group with the conesponding appendage can be introduced on the nitrogen atom of ring C of compounds of Formula I by one of the methods described below: Method A: General procedure was same as described earlier ( method A ). Only the core amine of Formula V is (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6 )-6-[N-methyl]amino]-3- azabicyclo [3.1.0] hexane] phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide here. Compound No. 31:(S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-( 5-nitro-2-furoyl)- N-methyl]amino]-3-azabicyclo-[3.1.0]hexane]phenyI]-2-oxo-5-oxazolidinyl]- methyl] acetamide PREPARATION OF (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6 )-6-[N-methyl]amino]-3- azabicyclo [3.1.0]hexane]phenyI]-2-oxo-5-oxazolidinyI]methyl]acetamide (core II) (a) PREPARATION OF 3-Fluoro[4-[3-(lα,5α,6 )-6-[N-(tert butoxy carbonyl) amino]-3-azabicyclo- [3.1.0]hexane] nitrobenzene. (lα, 5 , 6α)-6-Amino-3 -azabicyclo [3.1.0] hexane (7.0 g, 0.03535 mol) was taken in CH 3 CN (50 mL) and diisopropyl ethyl amine (4.5606 g, 0.03535 mol) was added followed by 3,4-difluoro nitrobenzene (5.6212 g, 0.03535 mol) and heated at 70°C for 4 hrs. The reaction was monitored by the disappearance of the starting material on the TLC (eluent CHCI 3 : MeOH (19:1)). The reaction mixture was concentrated under vacuum, triturated with H 2 O, filtered, washed with hexane and dried to obtain the title compound. Yield: 10 g δppm (CDCI 3 ) : 7.94-6.50 (m, 3H), 4.80 (5, IH) 3.95-3.63 (m, 4H), 2.43 (s, IH), 1.92 (5, 2H), 1.47 (s. 9H). (b) PREPARATION OF 3-FIuoro[4-[3-(lα, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N-methyl]-amino]-3-azabicyclo- [3.1.0]hexane]nitrobenzene 3-Fluoro[4-[3-(l , 5 α, 6 )-6-[N-(tert butoxy carbonyl)-amino]-3-aza- bicyclo- [3.1.0] hexane] nitro benzene (lOg, 0.029 mol) was taken in 60 ml THF at 0 C. Sodium hydride (1.06 g, 0.045 mol) was added portion-wise over 5 min. After complete addition the reaction mixture was stined for 30 min. at 0°C. Methyl iodide (8.42 g, 0.059 mol) was then added over 10 min. at 0°C followed by tert n-butyl ammonium iodide (lg). The reaction mixture was stined for 4 hrs. The reaction mixture was then concentrated under vacuum. H..O (50 mL) was added followed by extraction with dichloromethane (3 x 50 mL). The combined organic layer was dried over Na 2 SO 4 , filtered and concentrated to obtain the title compound. Yield: 10.25 g δppm (MeOD): 7.91-6.47 (m, 3H), 3.89-3.61 (m, 4H) 2.8 (s, 3H), 2.34 (s, IH), 1.96 (s, 2H), 1.46 (5, 9H). (c) PREPARATION OF 3-Fluoro [4-{3-(lα, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N-methyl amino}-3-azabicyclo- [3.1.0] hexane] aniline. 3-Fluoro[4-[3-(l α, 5 α, 6 )-6-[N-(tert butoxy carbonyl)-N-methyl]-amino]- 3-azabicyclo- [3.1.0]hexane]nifrobenzene (26 g, 0.074 mol) was taken in 75 mL THF and 75 mL MeOH. 10% Pd/C (dry) (3g) was added and the reaction mixture was shaken in a Pan hydrogenator at 40 psi for 3 hours. The reaction mixture was filtered through celite bed. The filtrate was concentrated to obtain the title compound. Yield: 21.2 g δppm (CDC1 3 ) (MeOD): 6.55-6.33 (m, 3H), 3.54-3.00 (m, 4H) 2.87 (s, 3H), 2.55 (s, IH), 1.96 (s, 2H) 1.40 (s, 9H). (d) PREPARATION OF 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N-methyl]ammo]-3-azabicycIo- [3.1.0]hexane]benzyloxy carbamate 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert-butoxy carbonyl)-N-methyl)amino]-3- azabicyclo [3.1.0] hexane] aniline (21g, 0.065 mol) was taken in THF (100 ml and cooled to -15 C. Sodium bicarbonate (27.47 g, 0.32 mol) was added followed by benzyl chloroformate (14.5 g, 0.055 mol) which was added slowly over 30 min. After complete addition the stirring was combined for the maintaining the temperature between 0-5°C. The reaction was monitored by the disappearance of the reaction mixture on TLC (eluent CHC1 3 : MeOH : 9:1). The reaction mixture was filtered and filtrate concentrated under vacuum. H 2 O (20 ml) was added and extracted with CH 2 C1 2 (3x100 ml). The combined organic layer was dried over Na 2 SO4- This was filtered and the filtrate concentrated. The semisolid was triturated with MeOH. The solid was filtered to obtain the title compound. δppm (CDCI3) : 7.4:6.5 (m, 8H), 5.24 (s, 2H), 3.8-3.3(m, 4H), 2.92 (s, 3H), 2.61 (s, IH), 1.90 (s, 2H), 1.54 (s, 9H, tBu). (e) PREPARATION OF (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-(N- (tert butoxy carbxy-N-methyl]amino]-3- azabicyclo [3.1.0]hexane]phenyl]-2-oxo- 5-oxazolidinyl] methyl alcohol. 3-Fluoro[4-[3-(l , 5 α, 6 α)-6-(N-(tert butoxy carbonyl)-N-methyl]amino]-3- azabicyclo [3.1.0]hexane]benzyloxy carbamate (21 g, 0.04615 mol) was taken in freshly distilled THF (200 mL). The system was thoroughly flushed with N 2 . The temperature was then brought down to -78°C in acetone dry ice. n-BuLi (59.13 mL of 15% solution in hexane, 0.13846 mol) was added over 30 min. maintaining the temperature at -78°C. The stirring was continued for 2.5 hours at -78°C. R(-) Glycidyl butyrate was added in one go and stined at -78°C for further 1.5 hours. The temperature was gradually increased to rt. and stined over night. 20% aqueous solution of NH 4 CI (200ml) was then added gradually added over 10 min. After 30 min. stirring, the organic layer was separated. The aqueous layer was further extracted with EtOAc (3 x 75 ml). The combined organic was dried over Na.SO 4 , filtered and concentrated. The product was purified by silica gel column chromatography (100-200) eluent (2% MeOH: 98% CHC1 3 ) to yield 14 g. δppm (CDCI3) : 7.35-6.55 (m, 3H), 4.7 (m, IH), 3.9-3.8 (m, 4H), 3.7-3.2 (m, 4H), 2.8 (s, 3H, N-CH 3 ), 2.5 (S, IH), 1.8 (s, 2H), 1.47 (s, 9H). (f) PREPARATION of (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 a, 6 a)-6-[N- (tert butoxy carbonyl)-N-Methyl]amino]-3-azabicycIo[3.1.0]hexane]phenyl]-2- oxa-5-oxazolidinyl] methyl methanesulfonate. (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N- methyl] amino] -3 -azabicyclo [3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]methyl alcohol (16 g, 0.038 mol) was taken in 50 ml pyridine at 5-10°C and methane sulphonyl chloride (12.71 g, 0.14 mol) was added over 5 min. The stirring was continued for 4 hours. The progress of the reaction was monitored by the disappearance of the starting material on TLC (eluent 10% CHC1 3 : 10% MeOH). The reaction mixture was filtered, filtrates concentrated under vacuum, washed with H 2 O (50 ml) and extracted with CH 2 C1 2 (3 x 75 mL). The combined organic layer was dried over Na 2 SO 4 , filtered and filtrate concentrated. This was dried thoroughly under vacuum. (g) PREPARATION OF (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N- (tert butoxy carbonyl)-N-Methyl]amino]-3- azabicyclo[3.1.0]hexane]phenyl]-2- oxa-5-oxazolidinyl ] methyl azide. (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N- methyl]amino]-3-azabicyclo [3.1.0] hexane]phenyl]-2-oxa-5-oxazolidinyl]methyl methane sulphonate (15 g, 0.03 mol) was taken in DMF (50 ml) and NaN 3 (9.76 g, 0.15 mol) was added and heated at 70°C for 4 hours. The progress of the reaction was monitored by the disappearance of the starting material on TLC. The reaction mixture was filtered. The filtrate was concentrated under vacuum. This was washed with H 2 O and extracted EtOAc (3x75 ml). The combined organic layer was dried over Na 2 SO 4 , filtered and concentrated to obtain the title compound. Yield 11.5 g. δppm (CDCI3) : 7.3-6.5 (m, 3H), 4.7 (m, IH) (h) PREPARATION OF (S)-N-[3-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6- [N-(tert butoxy carbonyl)-N-methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2- oxo-5-oxazolidinyI] methyl amine (S)-N-[3-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N- methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl azide (11.3 g, 0.026 mol) was taken in 75 ml MeOH and 75 ml EtOAc and 10% Pd/C was added. The reaction mixture was shaken at 50 psi for 6 hrs. The progress of the reaction was monitored by the disappearance of the starting material on the TLC. The reaction mixture was filtered through a celite bed. The filtrate was concentrated. The product was triturated with diethyl ether. The solid was filtered, to obtain the title compound. Yield - 7.6 g. (i) PREPARATION OF (S)-N-[3-[3-FIuoro[4-[3-(l α, 5 α, 6 α)-6-[N- (tert butoxy carbonyl)-N-Methyl]amino]-3- azabicyclo[3.1.0]hexane]phenyl]-2- oxa-5-oxazolidiny I] acetamide. (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N- methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl amine (7.6g, 0.018 mol) was taken in pyridine (8 ml), CH 2 C1 2 (50 mL) and acetic anhydride (2.214 g, 0.0217 mol) at 0-10°C. The reaction mixture was stined and the progress of the reaction was monitored by the disappearance of the starting material on the TLC eluent (CHC1 3 : MeOH :: 9:1). The reaction mixture was concentrated under vacuum. The concentrate was washed with H 2 O (50 mL) and extracted with CH 2 C1 2 (3x50 mL). The combined organic layer was dried over Na 2 SO 4 , filtered and concentrated. This product was triturated with diethyl ether, filtered and dried to yield the little compound. Yield: 6.6 g. δppm (CDCI 3 ) : 7.33-6.56 (m,3H), 6.19 (t, IH), 4.73 (m, IH), 3.98 (t, IH), 3.77-3.2 (m, 7H) 2.8 (s, 3H), 2.52 (s, IH), 2.0 (s, 3H), 1.96 (S, 2H), 1.48 (s, 9H). (j) PREPARATION OF (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N- Methyl]amino]-3- azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl] acetamide. (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 )-6-[N-(tert butoxy carbonyl)-N- Methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]acetamide (lg) was taken in CH 2 C1 2 (50mL) at 0°C and CF 3 COOH(10 mL) was added and stined for 4h. The reaction mixture was concentrated under vacuum. The residue was dissolved in EtOAc and neutrallised with solid NaHCO 3 . The EtOAc layer was filtered and the filterate was concentrated to obtain the title compound. Compound No. 31: (S)-N-[[3-[3-FIuoro[4-[3-(lα, 5α, 6α)-6-[N-( 5-nitro-2-furoyl)- N-methyl]amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]acet- amide and 5-nitro-furoyl chloride using Method A. δppm (CDCI 3 ) : 7.7-60 (m, 6H), 4.74 (m, IH), 4.0-2.9 (m, 1 IH), 2.43 (s, 2H), 2.01 (s, 3H), 1.62 (s, IH), 1.91 (s, 2H) Compound No. 32: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5α, 6α)-6-[N-(3-furoyl)-N-meth- yl]amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6- [N-methyl] amino] -3 -azabicyclo [3.1.0]hexane]phenyl] -2-oxa-5 -oxazolidinyl] acetamide and furan-3-carboxyaldehyde using Method B. Compound No. 71: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5α, 6α)-6-[N-( 2-thiophene- acetyl)-N-methyl] amino] -3-azabicyclo- [3.1.0] hexane] phenyl] -2-oxo-5-oxazol- idinyl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6- [N-methyl] amino] -3-azabicyclo [3.1.0]hexane]phenyl] -2-oxa-5 -oxazolidinyl] acetamide and 2-thiopheneacetyl chloride using Method A. Compound No. 72: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5α, 6α)-6-[N-(5-formyl-2-furyl- methyl)-N-methyl]amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazol- idinyl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]acet- amide and 5-formyl-2-furylmethyl chloride using Method A. Compound No. 73: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5α, 6α)-6-[N-(3-thienoyl)-N- methyI]amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazoIidinyI] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]acet- amide and 3- chlorothienoyl chloride using Method A. Compound No. 33: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5α, 6α)-6-[N-( 5-bromo -2- furoyl)-N-methyl]amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidin- yl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6- [N-Methyl] amino] -3 -azabicyclo [3.1.0]hexane]phenyl] -2-oxa-5-oxazolidinyl] acetamide and 5-bromo 2 — furoyl chloride using Method A. Method B: General procedure was same as described earlier in section 7.1.1.2. (Method B) described earlier for example Rbx-6247. Only the core amine of Formula V is (S)- N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-methyl]amino]-3-azabicyclo[3.1.0]hexane]- phenyl] -2-oxo-5 -oxazolidinyl]methyl] acetamide here. Compound No. 34: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5α, 6α)-6-[N-(5-nitro-2-thienyI- methyl)-N-methyl]amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazol- idiny 1] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]acet- amide and 5-nifro-thiophene-2-carboxyaldehyde using Method B. Compound No. 35: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5a, 6a)-6-[N-(5-nitro-2-furyl- methyl)-N-methyl]amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazol- idinyl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]acet- amide and 5-nitro-furan-2-carboxyaldehyde using Method B. Analogues of (S)-N-[3-[3-FIuoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)- N-Methyl] amino methyl]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidin- yl] acetamide (core III). The heteroaromatic group with the conesponding appendage can be introduced on the nitrogen atom of ring C of compounds of Formula I by one of the methods described below: Method A: General procedure was same as described earlier in section 7.1.1.1 (Method A) described earlier for example Rbx-6408. Only the core amine of Formula V is (S)-N- [3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N-Methyl] amino methyl]-3- azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl] acetamide (core III). Compound No. 36: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5a, 6a)-6-[N-(5-formyl-2-fur- ylmethyl)-N-methyl]aminomethyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide (a) PREPARATION OF 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)- aminomethyl]-3-azabicyclo- [3.1.0]hexane] nitrobenzene. (1 α, 5 α, 6 α)-6-Aminomethyl-3 -azabicyclo [3.1.0] hexane (7.0 g, 0.03535 MH) was taken in CH 3 CN 50 mL and diisopropyl ethyl amine (4.5606 g, 0.03535 mol) was added followed by 3,4-difluoro nifrobenzene (5.6212 g, 0.03535 mol) and heated at 70°C for 4 hrs. The reaction was monitored by the disappearance of the starting material on the (eluent CHC1 3 (19): MeOH (1). The reaction mixture was concentrated under vacuum, triturated with H 2 O, filtered, washed with hexane and dried to obtain the title compound. (b) PREPARATION OF 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N-Methyl]-ammomethyl]-3-azabicyclo- [3.1.0]hexane]nitro- benzene 3-Fluoro [4-[3-(l α, 5 α, 6 α)-6-[N-(test butoxy carbonyl)-N-methyl]- aminomethyl]-3- azabicyclo- [3.1.0]hexane] nitrobenzene (lOg, 0.029) was taken in 60 ml THF at 0°C. Sodium hydride (1.06 g, 0.045 mol) was added portion-wise over 5 min. after complete addition the reaction mixture was stined for 30 min. at 0°C. Methyl iodide (8.42 g, 0.059 mol) was then added over 10 min. at 0°C followed by tat n-butyl ammonium iodide (lg). The reaction mixture was stined for 4 hrs.. The reaction mixture was then concentrated under vacuum. H 2 O (50 mL) was added followed by extraction with CH 2 C1 2 (3 x 50 mL). The combined organic layer was dried over Na 2 SO 4 , filtered and concentrated to obtain the title compound. (c) PREPARATION OF 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-NethyI] -aminomethyl] -3-azabicyclo- [3.1.0] hexane] aniline 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N-Methyl]- aminomethyl] -3-azabicyclo- [3.1.0]hexane]nitro benzene (26 g, 0.074 mol) was taken in 75 mL THF and 75 mL MeOH. 10% Pd dry (3g) was taken in 75 ml THF and 75 mL MeOH. 10% Pd C dry (3g) was added and the reaction mixture was shaken in a pan hydrogenator at 40 for 3 hours. The reaction mixture was filtered through celite led. The filtrate was concenfrated to obtain the title compound. (d) PREPARATION OF 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxycarbonyl)-N-methyl]amino]-3-azabicycl-[3.1.0]hexane]benzyloxy carbamate 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert-butoxy carbonyl)-N-methyl)amino- methyl]-3-azabicyclo [3.1.0] hexane] aniline (21g, 0.065 mol) was taken in THF (100 ml and cooled to -15°C. Sodium bicarbonate (27.47 g, 0.32 mol) was added followed by benzyl chloroformate (14.5 g, 0.055 mol) which was added slowly over 30 min. after complete addition the stirring was combined for the maintaining the temperature between 0-5°C. The reaction was monitored by the disappearance of the reaction mixture on TLC (eluent CHC1 3 : MeOH : 9:1). The reaction mixture was filtered and filtrate concenfrated under vacuum. H 2 O (20 ml) was added and extracted with CH2C12 (3x100 ml). The combined organic layer was dried over Na 2 SO 4 . This was filtered, filtrate concentrated. The semisolid was triturated with MeOH. The solid was filtered to obtain the title compound. (e) PREPARATION OF (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-N-(tert butoxy carb oxy-N-methyl] amino methyl]-3- azabicyclo [3.1.0]hexane]phenyl]-2- oxo-5-oxazolidinyl] methyl alcohol. 3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-(N-(tert butoxy carbonyl)-N-methyl]amino- methyl]-3-azabicyclo [3.1.0]hexane]benzyloxy carbamate (21 g, 0.04615 mol) was taken in freshly distilled THF (200 mL). The system was thoroughly flushed with N 2 . The temperature was then brought down to -78°C in acetone dry ice. n-BuLi (59.13 mL of 15% solution in hexane, 0.13846 mol) was added over 30 min. maintaining the temperature at -78°C. The stirring was continued for 2.5 hours at -78°C. R(-) Glycidyl butyrate was added in one go and stined at -78°C for further 1.5 hours. The temperature was gradually increased to rt. and stined over night. 20% Solution of NELiCl (200ml) was then added gradually added over 10 min. after 30 min. stirring, the organic layer was separated. The aqueous layer was further extracted with EtOAc (3 x 75 ml). The combined organic was dried over Na 2 SO 4 , filtered and concentrated. The product was purified by silica gel column chromatography (100-200) eluent (2% MeOH: 98% CHC1 3 ) to yield 14 g. (f) PREPARATION OF (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- [N- (tert butoxy carbonyl)-N-methyl]aminomethyl]-3- azabicyclo[3.1.0]hexane]- phenyl]-2-oxa-5-oxazolidinyl] methyl methanesulfonate. (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N- methyl]aminomethyl]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]meth- yl alcohol (16 g, 0.038 mol) was taken in 50 ml pyridine at 5-10°C and methane sulphonyl chloride (12.71 g, 0.14 mol) was added over 5 min. The stirring was continued for 4 hours. The progress of the reaction was monitored by the disappearance of the starting material on TLC (eluent 10% CHC1 3 : 10% MeOH). The reaction mixture was filtered, concenfrated under vacuum, washed with H 2 O (50 ml) and extracted with CH 2 C1 2 (3 x 75 mL). The combined organic layer was dried over Na 2 SO 4 , filtered and filtrate concentrated. This was dried thoroughly under vacuum. (g) PREPARATION OF (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N- (tert butoxy carbonyl)-N-Methyl]amino methyl]-3- azabicyclo [3.1. OJhexane]- phenyl] -2-oxa-5-oxazolidinyl] methyl azide. (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- [N-(tert butoxy carbonyl)-N- methyl]aminomethyl]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]meth- yl methane sulphonate (15 g, 0.03 mol) was taken in DMF (50 ml) and NaN 3 (9.76 g, 0.15 mol) was added and heated at 70°C for 4 hours. The progress of the reaction was monitored by the disappearance of the starting material on TLC. The reaction mixture was filtered. The filtrate was concentrated under vacuum. This was washed with H 2 O and extracted EtOAc (3x75 ml). The combined organic layer was dried over Na 2 SO 4 , filtered and concentrated to obtain the title compound. Yield: 11.5 g. (h) PREPARATION OF (S)-N-[3-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6- [N-(tert butoxy carbonyl)-N-methyl]aminomethyl]-3-azabicyclo[3.1.0]hexane]- phenyl]-2-oxo-5-oxazolidinyl] methyl amine (S)-N-[3-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N- methyl]aminomethyl] -3 -azabicyclo [3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]meth- yl azide (11.3 g, 0.026 mol) was taken in 75 ml MeOH and 75 ml EtOAc and 10% Pd C was added. The reaction mixture was shaken at 50 psi for 6 hrs. The progress of the reaction was monitored by the disappearance of the starting material on the TLC. The reaction mixture was filtered through a celite bed. The filtrate was concentrated. The product was triturated with diethyl ether. The solid was filtered, to obtain the title compound. Yield - 7.6 g. (i) PREPARATION OF (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N- (tert butoxy earbonyl)-N-Methyl] amino methyl]-3- azabicyclo[3.1.0]hexane]- phenyl]-2-oxa-5-oxazolidinyI] acetamide. (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N- methyl]aminomethyl]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]meth- yl amine (7.6g, 0.018 mol) was taken in pyridine (8 ml), CH 2 C1 2 (50 mL) and acetic anhydride (2.214 g, 0.0217 mol) at 0-10°C. The reaction mixture was stined and the progress of the reaction was monitored by the disappearance of the starting material on the TLC eluent (CHC1 3 : MeOH :: 9:1). The reaction mixture was concentrated under vacuum. The reaction mixture was washed with H 2 O (50 mL) and extracted with CH 2 C1 2 (3x50 mL). The combined organic layer was dried over Na 2 SO 4 , filtered and concentrated. This product was triturated with diethyl ether, filtered and dried to yield the little compound. Yield - 6.6 g. G) PREPARATION OF (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N- methyl]aminomethyl]-3- azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl] acetamide. (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)-6-[N-(tert butoxy carbonyl)-N- Methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]acetamide (lg) was taken in CH 2 C1 2 (50mL) at 0°C and CF 3 COOH(10 mL) was added and stined for 4h. The reaction mixture was concentrated under vacuum. The residue was dissolved in EtOAc and neutrallised with solid NaHCO 3 . The EtOAc layer was filtered and the filterate was concentrated to obtain the title compound. (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5a, 6a)-6-[N-(5-formyl-2-furylmethyl)-N- methyI]aminomethyl]-3-azabicyclo-[3.1.0]hexane]phenyI]-2-oxo-5-oxazoIidinyI]- methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]aminomethyl]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl] acetamide and 5-formamido-2-furylmethylene chloride using Method A. Compound No. 37: (S)-N-[[3-[3-Fluoro[4-[3-(lα, 5α, 6α)-6-[N-(5-carboxyethyl- 2-furylmethyl)-N-methyl]aminomethyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2- oxo-5-oxazolidinyl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]aminomethyl]-3- azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5- oxazolidinyl] acetamide and ethyl -5-(chloromethyl)-2-furan carboxylate using Method A. Compound No. 38: (S)-N-[[3-[3-FIuoro[4-[3-(lα, 5a, 6a)-6-[N-(2-thiophene- acetyl)-N-methyl] aminomethyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]amino]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl]acet- amide and 2-thiopheneacetyl chloride using Method A. Method-B: General procedure was same as described earlier in section 7.1.1.2. (Method B) described earlier. Only the core amine of Formula V is (S)-N-[3-[3-Fluoro[4-[3- (1 α, 5 α, 6 α)-6-[N-Methyl]aminomethyl]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa- 5-oxazolidinyl] acetamide (core III) Compound No. 39: (S)-N-[[3-[3-Fluoro[4-[3-(lα,5 α,6 α)-6-[N-(5-nitro-2-thienyl- methyl)-N-methyl] aminomethyl] -3-azabicyclo- [3.1.0] hexane] phenyl] -2-oxo-5- oxazolidinyl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]aminomethyl]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl] acetamide and 5-nitro thiophene-2-carboxyaldehyde using Method B as in example rbx-6408. Compound No. 40: (S)-N-[[3-[3-Fluoro[4-[3-(l α,5 α,6 α)-6-[N-(5-nitro-2-furyl- methyl)-N-methyl] aminomethyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide The title compound was made using (S)-N-[3-[3-Fluoro[4-[3-(l α, 5 α, 6 α)- 6-[N-Methyl]aminomethyl]-3-azabicyclo[3.1.0]hexane]phenyl]-2-oxa-5-oxazolidinyl] acetamide and 5 -nifro-furan-2-carboxy aldehyde using Method B. Analogues of (S)-N-{3-[4-[4-N-methyl amino peperidin-l-yl]-3-fluoro- phenyl}-2-oxo-oxazo!idin-5-yl]methyl acetamide (core IV). The heteroaromatic group with the conesponding appendage can be introduced on the nitrogen atom of ring C of compounds of Formula I by one of the methods described below: Method-A: General procedure was same as described earlier (Method A). Only the amine of Formula N is (S)-Ν-{3-[4-[4-Ν-methyl amino piperidin-l-yl]-3-fluorophenyl}-2- oxo-oxazolidin-5-yl]methyl acetamide (core IN). Compound No. 74 Preparation of (S)-N-[[3-[4-[4-(N-methyl-N-2furyl(5-formyl)- methylaminopiperidine-1-yl] -3-fluorophenyl] -2-oxo-oxazolidin-5-yl] methyl] - acetamide. Preparation of (S)-N-{3-[4-[4-N-methyl amino piperidin-l-yI]-3- fluorophenyl}-2-oxo-oxazolidin-5-yl] methyl acetamide ( core IV) (a) l-[4(N-t-ButyloxycarbonyIamino)piperidin-l-yl]-3-fluoro]- nitrobenzene To a solution of difluoronitrobenzene (40g; 200 mmol) in acetonitrile (400 ml) was treated with ethyldiisopropyl amine (28.4 g; 219.72 mmol) and 4-(t- butyloxycarbonyl) amino piperidine (31.8g; 199 mmol). The whole reaction mixture was then heated at 60°C for 6.0 hr. The solution was cooled to ambient temperature and cone, in vacuo. The residue was dissolved in ethyl acetate and washed with water. Ethyl acetate layer was dried over anhydrous sodium sulphate. Solvent was removed to afford a yellow solid (60g). δppm (CDCI 3 ) : 7.98-7.80 (m, 2H), 6.91 (t, J=9Hz, IH) 4.53 (bs, IH), 3.65 (d,J=12Hz, 3H) 2.98 (t, J=13Hz, 2H), 2.07 (m, 2H), 1.69-1.53 (m, 3H), 1.52 (s, 9H). (b) l-[4-(N-t-Butyloxy carbonyl N methyl)aminopiperidin-l-yl]-3- fluoro] nitrobenzene ( B) To a solution of intermediate A (89 mmol) in dry tetrahydrofuran (400 ml) was added sodium hydride (60%, 106 mmol) in cold condition (O°C) followed by tetrabutyl ammonium iodide (10 mmol). The reaction mixture was stined at cold to r.t. for 2.0 hr. Methyl iodide (267 mmol) was then added at 0°C. Reaction mixture was stined at r.t. for 12 hr. A faster moving spot was appeared. Excess sodium hydride was decomposed with water. Tefrahydrofiiran was removed. The residue was dissolved in ethyl acetate, washed with water, brine and then with water. Organic layer was dried over anhydrous sodium sulphate and solvent was removed. A yellow solid (32g) was obtained. δppm (CDC1 3 ) : 6.81 (t, J=12Hz, IH) 6.44-6.37 (m, 2H), 4.70 (bs, IH) 2.91 (d, J=12H, 2H), 2.78 (s, 3H), 2.72-2.65 (m, 2H), 1.47 (s, 9H). (c) l-[4-[(N-t-butyloxycarbonyl-N-methyl)amino-piperidin-l-yl]- fluoro]anilme (C) A mixture of nitro compound B, (32.0g ), 3.2 g of 10% palladium on carbon in 75 ml of methanol was shaken in a Paar shaker flask under 40 Psi hydrogen for 6.0 hr. TLC showed a slower moving spot. The reaction mixture was filtered through celite. Solvent was removed. A dark solid was obtained (28.6 g), it was subjected to next step without further characterisation. (d) l-{N-Carbobenzyloxy-[4-[(N-t-butyloxy carbonyl-N-methyl)- peperidin-l-yl]}-3-fluoro] aniline (D) To the solution of aniline derivative C ( 19.0 g, 58.823 mmol) in dry tetrahydrofur an (150 ml) was added. Sodium hydrogen carbonate (19.76 g, 235.29 mmol). It was cooled to O°C and benzyl chloroformate (12.9 ml, 50%) toluene sol.) was added. The whole reaction mixture was stined at O°C-r.t. for 6.0 hr. TLC showed faster moving spot compare to aniline derivative. Reaction mixture was filtered through celite. Solvent removed. Residue was digested with hexane and solvent was removed to give 23.4g of CBz derivative. δppm (CDC1 3 ) : 7.39-7.28 (m,6H), 6.99-6.86 (m,2H), 6.75 (bs, IH), 5.20 (s, 2H), 4.20 (bs, IH), 3.43 (d, I=12Hz, 2H), 2.79 (s, 3H), 2.71 (m, 2H), 1.97-1.86 (m, 2H), 1.49 (s, 9H) (e) (S)~N-{3~[4-[4-(N-methyI-N-t-butyIoxy carbonyl)ammo-piperidin- l-yl]-3-fluorophenyl}-2-oxo-oxazolidin-5-yl]methanol (E) To a solution (200 ml) of CBz derivative in (D; 24.0g, 52.516 mmol) dry tefrahydrofiiran was added. BuLi (67 ml, 157 mmol) at -78°C under N 2 . The reaction mixture was stined at -78°C for 2.0 hr. Glycidyl butyrate (9.07g, 62.98 mmol )was then added to the reaction mixture at -78°C. It was stined at -78°C for 1 hr. then allowed to reach r.t. TLC of the reaction mixture showed a slower moving spot. Ammonitim chloride (30ml) was added to the reaction mixture. It was stined for 5 min. Ammonium chloride layer was separated and extracted with ethyl acetate. Tefrahydrofiiran and ethyl acetate layer were combined, dried over anhydrous sodium sulphate. Solvent was removed. The residue was purified by column chromatography using CHCI3 : MeOH (1.5%-2.5% )as eluent to give lOg of desired alcohol. δppm (CDCI 3 ) : 7.46 (d, 1=8.0 Hz, IH), 7.10 (d, J=9Hz, IH), 6.94 (t, J=9Hz, IH) 4.55 (bs, IH), 4.07-3.87 (m, 5H), 3.74 (bs, IH), 3.46 (bs, IH), 3.42 (bs, IH), 2.78-2.89 (m, 5H), 1.96-1.85 (m, 2H), 1.72 (s, IH), 1.47 (s, 9H). (f) (S)-N-{3-[4-[4-(N-Methyl-N-t-butyloxy carbonyl)aminopiperidin-l- yl)-3-fluorophenyl}-2-oxo-oxazolidine-5-yl}methyl methane sulfonate (F) To a solution of hydroxymethyl compounds (E, 24g, 56.73 mmol) in dichloromethane (400 ml) was added triethylamine (11.46 g, 113.46 mmol) followed by methane sulphonyl chloride at O°C. The reaction mixture was stined at O°C - r.t. for 3.0 hr. TLC of the reaction mixture showed a faster moving spot. The reaction mixture was poured in to water and exfracted with dichloromethane, washed with saturated sodium bicarbonate solution and then with water. Organic layer was dried over anhydrous sodium sulphate and solvent was removed to give 28.4g of compound (F). δppm (CDCI 3 ) : 7.45 (d, I=12Hz, IH), 7.10-7.01 (m, 2H), 4.92 (bs, IH), 4.53- 4.40 (m, 2H),4.12(t,J=9Hz,lH),7.10-7.01 (m, 2H), 4.12 (t, J=9Hz, IH), 3.94-3.89 (m, IH), 3.48 (d, J=12Hz, 2H), 3.15 (m, IH), 3.11 (s, 3H) 2.79 (s, 3H), 1.97-193 (m, 2H), 1.77-1.69 (m, 4H), 1.48 (s, 9H). (g) (S)-N-{3-[4-[4-(N-MethyI-N-t-butyloxy carbonyl)aminopiperidin-l- yl)-3-fluorophenyl]-3-fluorophenyl]-2-oxo-oxazolidin-5-yl}methyl azide (G) To the solution of mesyl derivative (F, 28.4 g, 56.68 mmol) in dimethyl formamide (350 ml) was added sodium azide (11.059, 70.05 mmol). The whole reaction mixture was heated at 80°C for 9.0 hr. TLC showed a faster moving spot. Reaction mixture was filtered. Dimethyl formamide was removed in reduced pressure. The residue was digested in hexan to afford desired azide in 26.0 g. δppm (CDCI 3 ) : 7.44 (d, 12Hz, IH), 7.11 (bs, IH), 6.97 (t, j=9Hz, IH) 4.78 (bs, IH), 4.09-3.49 (m, 7H), 2.90 (s, 3H), 2.75 (bs, 2H) 1.49 (s, 9H). (h) (S)-N-{3-[4-[4-(N-Methyl-N-t-butyloxy carbonyI)aminopiperidin-l- yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-yl} methyl amine (H). To the solution of azido compound (G, 25.5g, 56.92 mmol) in methanol (50 ml) was added, 10% Pd/c (2.5 g). The whole reaction mixture was hydrgogenated for 10 hr. at 40 Psi. TLC showed a slower moving spot. It was filtered through celite bed and solvent was removed to give desired product of 24.5 g. δppm (CDCI 3 ) : : 7.45 (d, J=12Hz, IH), 7.11 (d, J=9Hz, IH), 6.94 (t, J=9Hz, IH) 4.66 (bs, IH), 4.00 (t, J=9Hz, IH), 3.81 (t, J=9Hz, IH), 3.45 (d,I=9Hz, 2H) 3.10- 2.90 (m, IH), 2.78 (3 3H), 2.73 (bs, IH), 1.48 (s, 9H). (i) (S)-N-{3-[4-[4-(N-Methyl, N-1-butyloxy carbonyl) amino piperidin- l-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-yI} methyl acetamide.(I) To a solution of methyl amino derivative (7.0g, 16.58 mmol) in dichloro methane (120 ml) was added triethyl amine (2.18g; 21.58 mmol) reaction mixture was cooled to 0°C and acetic anhydride was added slowly. It was stined at 0°-r.t. for 5.0 hr. TLC showed a faster moving spot. Reaction mixture was poured into water and extracted with dichloromethane. Organic layer was washed with sodium bicarbonate, brine and water. Organic layer was dried over anhydrous sodium sulphate and solvent was removed to give 7.1 g of crude desired product which on purification gave 4.1 g of pure product. δppm (CDCI 3 ) :7.43 (d, J=12Hz, IH), 7.07 (d, J=9Hz, IH), 6.95 (t, J=9Hz, IH) 6.28 (bs, IH), 4.00 (t, J=9Hz, IH), 3.78-3.62 (m, 3H), 3.47 (d,J=9Hz, 2H) 2.80 (s, 3H), 2.75-2.71 (m 2H), 2.03 (s, 3H), 1.49 (s, 9H). (j) (S)-N-[3-[4-[4-N-methyl)amino piperidin-l-yI]-3-fluorophenyl}-2- oxo-oxazolidin-5-yI] methyl acetamide.(J) To a solution of Boc protected compound (I, 2.0 g, 4.31 mmol) in dichloromethane (35 ml) was added trifluoroacetic acid (5 ml) at O°C. The whole reaction mixture was stined at O° r.t. for 3 hr. TLC of the reaction mixture showed a slower moving spot. Solvent was removed and the residue was dissolved in acetone, anhydrous pot. Carbonate was added to neutralize trifluoro acetic acid. It was stirred at r.t. for 2.0 min. then filtered through a Buckner funnel. Solvent was removed and the title compound was obtained. Yield: 1.5g Compound No. 41: (S)-N-[[3-[4-[4-(N-methyl-N-2furyl(5formyl)methyl- aminopiperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine- 1 -yl] -3 -fluorophenyl] -2oxo-oxazolidin-5 -yljmethyl] acetamide and 5 - chloromethyl -2- furfural following Method A. Compound No. 42: (S)-N-[[3-[4-[4-(N-methyl-N-(3,5-difluorobenzoyl)amino- piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yI] methyl] acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 3,5, difluoro benzoyl chloride following Method A. Compound No. 43: (S)-N-[[3-[4-[4-(N-methyl-N-(5-bromo-2-furoyl)amino- piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl] methyl] acetamide The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piper- idine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 5-bromo-2- furoyl chloride following Method A. Compound No. 44: (S)-N-[[3-[4-[4-(N-methyl-N-(5-nitro-2-furoyl)amino- piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piper- idine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 5-nitro-2- furoyl chloride following Method A. Compound No. 45: (S)-N-[[3-[4-[4-(N-methyl-N— 3-furoyl)aminopiperidine-l-yl]- 3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidm-5-yl]methyl]acetamide and 3-furoyl chloride using Method A. Compound No. 46: (S)-N-{3-[4-[4-(N-methyl, N- 2-furoyl )aminopiperidine-l-yl]- 3-fluorophenyl]-2oxo-oxazolidin-5-yl methyl] acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 2-furoyl chloride following Method A. Compound No. 47:(S)-N-{3-[4-[4-(N-methyl,2-thiopheneacetyl)aminopiperidine- l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl methyl]acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine- 1 -yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 2-thio- phene acetylchloride chloride following Method A. Method-B: General procedure was same as described earlier in section (Method B), only the amine of Formula V is (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine-l-yl]-3- fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide (core IV). Compound No. 48:(S)-N-[[3-[4-[4-(N-methyl-N-2furylmethyl) aminopiperidine-1- yl]~3~fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and ftιran-2- carboxaldehyde following Method B. Compound No. 49: (S)-N-[[3-[4-[4-(N-methyl-N-3-furyl)aminopiperidine-l-yl]-3- fluorophenyl]-2oxo-oxazolidin-5-yl] methyl] acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piper- idine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and furan-3- carboxaldehyde following METHOD B. Compound No. 50: (S)-N-[[3-[4-[4-(N-methyI-N-2-furyI(5-nitro)methyl)- aminopiperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl] methyl] acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 5- nitro furan -2- carboxaldehyde using Method B. δppm (CDC1 3 ) : 7.40(d, IH), 7.29 (m, IH), 7.29 (m, IH), 7.05 (dd, IH), 6.92 (t, IH), 6.48 (d, IH), 6.26 (bs, IH), 4.76 (bs, IH), 4.01 (t, IH), 3.77-3.60 (m, 5H), 3.47 (d, 2H), 2.66 (t, 3H), 6.26 (bs, IH), 4.76 (bs, IH), 4.01 (t, IH), 3.77-3.60 (m, 5H), 3.47 (d, 2H), 2.66 (t, 3H), 6.26 (bs, IH), 4.76 (bs, IH), 4.01 (t, IH), 3.77-3.60 (m, 5H), 3.47 (d, 2H), 2.66 (5, 3H), 2.37 (s, 3H), 2.01 (s, 3H0, 1.93-1.25 (m, 4H). Compound No. 51: (S)-N-[[3-[4-[4-(N-methyl-N-2-thienyl(5-nitro)methyl)- aminopiperidine-l-yl]-3-fluorophenyI]-2oxo-oxazolidin-5-yl] methyl] acetamide. The title compound was made using (S)-N-[[3-[4-[4-ι^-methyl-)amino piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 5- nifro thiophen-2-carboxaldehyde following Method B. δppm (CDCI 3 ) : 7.79 (d, IH), 7.41 (dd, IH), 7.05 (d, IH) 6.93 (t, 1H),6.85 (d, IH), 6.11 (bs, IH), 4.01 (t, IH) 3.82-3.45 (m, 7H), 2.66 (m, 3H), 2.37 (s, 3H), 2.02 (s, 3H) 1.82-1.25 (m, 4H) Compound No. 52: (S)-N-[[3-[4-[4-(N-methyl-N-2-thienylmethyl)aminopiper- idine-1 -yl] -3-fluorophenyl] -2oxo-oxazolidiή-5-yl] methyl] acetamide The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and thio- phen-2-carboxaldehyde following Method B. Compound No. 53: (S)-N-[[3-[4-[4-(N-methyl-N-(5-methyl-2-thienyl- methyl)aminopiperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl] methyl]- acetamide The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piperidine-1 -yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 5-meth- yl-thiophen-2- carboxaldehyde following Method B. Compound No. 54: (S)-N-{3-[4-[4-(N-methyl,2-(5-bromo)thienylmethyl)amino- piperidine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl methyI]acetamide. The title compound was made using (S)-N-[[3-[4-[4-(N-methyl-)amino piper- idine-l-yl]-3-fluorophenyl]-2oxo-oxazolidin-5-yl]methyl]acetamide and 5-bromo,- thiophen-2- carboxaldehyde Method B. Analogues of of (S)-N-[[3-[3[Fluoro-4-(N-l-homopiperazinyI)phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide (Core V) The heteroaromatic group with the conesponding appendage can be infroduced on the nitrogen atom of ring C of compounds of Formula I by one of the methods described below: Method-A: General procedure was same as described earlier in section 7.1.1.1 (Method A) described earlier for example Rbx-6408. Only the core amine of Formula V is (S)-N- {3-[4-[4-N-methylaminopeperidin-l-yl]-3-fluorophenyl}-2-oxo-oxazolidin-5-yl]- methyl acetamide (core V). Compound No. 55: (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-furyl(5- formyl)methyl}]- homopiperazinyl]phenyl]2-oxo-5-oxazoIidinyl]methyl]acetamide Preparation of (S)-N-[[3-[3[Fluoro-4-(N-l-homopiperazinyl)phenyl]-2- oxo-5-oxazolidinyl] methyl] acetamide (a) Preparation of l-(2-Fluoro-4-nitrophenyl)homopiperazine. To homopiperazine (5g, 0.05 mol) in acetonitrile (30 mL), 3.4- difluoronitrobenzene (3.17 g, 0.02 mol) was added and the reaction mixture was heated to reflux for 4 hrs. Then the solvent was evaporated and the residue taken in EtOAc and washed with water and brine solution. The EtOAc layer was dried over anhyd Na 2 SO 4 and evaporated in vacuo. The residue was digested with ether-hexane (1:20), decanted and dried in vacuo to get 3.7g of final product. δppm (CDC1 3 ): 7.9 (m, 2H, Ar-H), 6.75 (t, IH, Ar-H) 3.64 (m, 4H, CH 2 ), 3.08 (m, 2H, CH 2 ), 2.91 (m, 2H, CH 2 ), 1.96 (m, 2H, CH 2 ). (b) Preparation of l-(2-Fluoro-4-nitrophenyl)-4-fert-butoxycarbonyI- homopiperazine. To l-(2-Fluoro-4-nitrophenyl)homopiperazine (3.5 g, 14.6 mmol) in dichloromethane (100 mL) cooled to 5°C, triethylamine (0.2 mL, 1.46 mmole) and tert- butoxydicarbonate (4.15 g, 19.03 mmol) was added and the reaction mixture was stined for 18 hrs. The solvent was evaporated and to the residue hexane was added. The product precipitating out was filtered, washed with hexane and dried in air to yield 4.0g of the final product. δppm (CDCI 3 ): 7.93 (m, 2H, Ar-H), 6.78 (t, IH, Ar-H), 3.63 (m, 6H, CH 2 ), 3.43 (m, 2H, CH 2 ), 1.97 (m, 2H, CH 2 ), 1.50 (s, 9H, t-Bu). (c ) 3-Fluoro-4-(N-ter'-butoxycarbonylhomopiperazinyl)aniline. To 1 -(2-Fluoro-4-nifrophenyl)-4-tert-butoxycarbonylhomopiperazine (3.2g, 9.4 mmole) in methanol (30 mL), 10% palladium/carbon was added and shaken in a Pan hydrogenation apparatus under 40 psi of hydrogen gas for 3 hrs. Then the reaction mixture was filtered over celite and the filtrate evaporated in vacuum to yield 2.64 g of the final product. δppm (CDC1 3 ) : 6.81 (t, IH, Ar-H), 6.38 (m, 2H, Ar-H) 3.53 (m, 4H, CH 2 ) 3.21 (m, 4H, CH 2 ), 2.86 (br s, NH 2 ), 1.95 (m, 2H, CH 2 ), 1.45 (s, 9H, t-Bu). (d) N-BenzyloxycarbonyI-3-fluoro-4-(N-ter^butoxylcarbonylhomo- piperazinyl) aniline. To 3-Fluoro-4-(N-tert-butoxycarbonylhomopiperazinyl)aniline (2.6g, 8.4 mmol) in THF (25 ml) cooled to 5°C, sodium bicarbonate (0.85 g 10.1 mmol), was added and then benzylchloroformate (1.72g, 10 mmol) was added dropwise. The reaction mixture was stined for 18 hrs. at R.T. and then filtered. The filtrate was evaporated in vacuo. The residue was dissolved in dichloromethane and washed with saturated sodium bicarbonate solution and brine water. The organic layer was dried over anhyd Na 2 SO 4 and evaporated in vacuo to give 5.04 g of final product. δppm (CDCI3) : 7.35 (s, 6H, Ar-H), 6.84 (m, 2H, Ar-H), 6.54 (s, IH, NH), 5.17 (s, 2H, CH 2 ), 3.2-3.61 (m, 8H, CH 2 ), 1.93 (m, 2H, CH 2 ), 1.45 (s, 9H, t-Bu). (e) (R)- [N-3-[3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiperazin- yl]phenyl]-2-oxo-5-oxazoIidinyl]methanol To N-benzyloxycarbonyl-3-fluoro-4-(N-tert-butoxycarbonylhomopiperazin- yl)aniline (2.5 g, 5.6 mmol) dissolved in dry THF(25 mL), cooled to -78°C, butyl lithium(4.8 mL, 15% sol. in hexane, 11.3 mmol) was added under +ve pressure of nitrogen. The reaction mixture was stined at -78°C for 1.5 hrs. Then R-glycidyl butyrate (0.89 g, 6.2 mmol) was added and the reaction mixture was stined at -78°C for lhr and then at R.T. for 18 hrs. To it 25 mL of satd ammonium chloride solution was added and the reaction mixture extracted with EtOAc. The combined organic layers were washed with water and brine water, dried over anhydrous Na 2 SO 4 and evaporated in vacuo. The crude product (~3g) was purified by column chromatography (3% MeOH/CHCl 3 ) to yield 0.41 g of final product. δppm (CDC1 3 ) : 7.38 (d, IH, ArH), 7.04 (d, IH, Ar-H), 6.87 (t, IH, Ar-H), 4.72 (m, IH, CH), 4.1-3.2 (m, 1 IH, CH 2 ), 2.18 (br s, IH), 1.94 (m, 2H, CH 2 ), 1.45 (s, 9H, t-Bu). (f) (R)-[N-3[3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiperazin- yl] phenyl] -2-oxo-5-oxazolidinyI] methyl methanesulfonate. To the (R)-[N-3[3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiperazinyl]- phenyl]-2-oxo-5-oxazolidinyl]methanol (1.55 g, 3.8 mmol) in dichloromethane (10 mL) cooled to 5°C, triethylamine (0.76 g, 7.6 mmol) and methanesulfonylchloride (0.6 g, 5.3 mmoles) were added and the reaction mixture was stined for 1 hr. Then the reaction mixture was diluted with dichloromethane and washed with saturated sodium bicarbonate solution and brine. The organic layer was dried over anhydrous sodium sulfate and evaporated in vacuo to yield 1.39 of product. δppm (CDCI 3 ) : 7.32 (d, IH, ArH), 7.02 (d, IH, Ar-H), 6.87 (t, IH, Ar-H), 4.89 (m, IH, CH), 4.47 (m, 2H, CH 2 ), 4.09 (t, IH, CH), 3.89 (m, IH, CH), 3.65-3.2 (m, 8H,CH 2 ), 3.1 (s, 3H, CH 3 ), 1.94 (m, 2H, CH 2 ), 1.45 (s, 9H, t-Bu). (g) (R)-[N-3 [3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiper- azinyI]phenyl]-2-oxo-5-oxazoIidinyl]methyIazide. To (R)-[N-3[3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiperazinyl]- phenyl]-2-oxo-5-oxazolidinyl]methyl methanesulfonate compound (1.21 g, 2.5 mmoles) in DMF(10 mL), sodium azide (0.81g, 12 mmoles) was added and the reaction mixture heated to 80°C for 5 hrs. The solid was filtered off and the filterate evaporated in vacuo. The residue was dissolved in chloroform and washed with water and brine solution. The organic layer was dried over anhyd. Na 2 SO 4 and evaporated in vacuo to yield 1.2 g of the product. δppm (CDC1 3 ): 7.32 (d, IH, Ar-H), 7.04 (d, IH, Ar-H), 6.87 (t, IH, Ar-H), 4.75 (m, IH, CH), 4.02 (t,lH, CH), 3.8-3.2(m, IH, CH 2 ), 1.92 (M, 2H, CH 2 ), 1.45 (s, 9H, t-Bu). (h) (R)-[N-3-[3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiper- azinyl]phenyI]-2-oxo-5-oxazolidinyl]methylamine. To (R)-[N-3 [3-Fluoro-4-[N- 1 -(4-tert-butoxycarbonyl)homopiperazinyl]phen- yl] -2-0X0-5 -oxazolidinyl]methylazide (1.1 g, 2.5 mmol) in methanol (10 mL), 10% palladium/carbon (0.22 g) was added and the reaction mixture shaken in a Parr hydrogenation apparatus under 40 psi hydrogen pressure for 5 hrs. The reaction was filtered over celite and the filterate evaporated in vacuo to yield 0.9g of product. The product was used as such in next step without further purification and characterization. (i) (S)-N-[[3-[3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiper- azinyl] phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide. To (R)-[N-3-[3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiρerazinyl]phen- yl]-2-oxo-5-oxazolidinyl]methylamine (0.77 g, 1.9 mmol) in dichloromethane (10 mL), triethylamine (0.21 g, 2.17 mmol) and acetic anhydride (0.21 g, 2 mmol) were added and the reaction mixture was stined at R.T. for 30 minutes. Then the reaction mixture was diluted with dichloromethane and washed with saturated sodium bicarbonate solution and brine water. The organic layer was dried over anhydrous sodium sulfate and evaporated in vacuo. The residue was purified by column chromatography (2% MeOH/CHCl 3 ) to yield 0.48g of final product. δppm (CDC1 3 ): 7.35(d, IH, Ar-H), 7.02(d,lH, Ar-H), 6.86(t, IH, Ar-H), 5.96(t, IH, NH), 4.73(m, IH, CH), 3.99(t, IH, CH), 3.25-3.8(m, IH, CH2), 2.01(s, 3H. CH3), 1.95(m, 2H, CH2), 1.44(s, 9H, t-Bu). (j) (S)-N-[[3-[3 [FIuoro-4-(N-l-homopiperazinyl)phenyl]-2-oxo-5- oxazolidinyl] methyl acetamide To (S)-N-[[3-[3-Fluoro-4-[N-l-(4-tert-butoxycarbonyl)homopiρerazinyl]phen- yl]2-oxo-5-oxazolidinyl]methyl]acetamide (0.5g, 1.11 mmol) in dichloromethane (8 mL), trifluoroacetic acid (2 mL) was added and stined for 2 hrs. Then the reaction mixture was evaporated and dried in vacuo. To the residue in acetone (10 mL), potassium carbonate (0.78 g, 5.55 mmol) was added and stined for 15 mts. Then the reaction mixture was fitered and the filterate evaporated in vacuo to yield the product in quantitative yield. This product was used as such in next step without further characterization. Compound No. 55: (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-furyl(5-formyl)methyl}]homo- piper azinyl] phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-homo- piperazinyl)phenyl] -2-0X0-5 -oxazolidinyl]methyl acetamide and 2-formyl-5-chloro- methylfuran using Method A. δppm (CDCI3) : 9.61(s,lH,CHO), 7.35(d,lH,Ar-H), 7.2(d, IH, Ar-H), 7.02(d, IH, Ar-H), 6.83(t, IH, Ar-H), 6.48(s, IH, Ar-H), 5.96(t, 1H,NH), 4.72(m, !H, CH), 4.71(t, IH, Ar-H), 4.14 (s, IH, CH 2 ), 3.2-3.8(m., 7H, CH 2 ), 2.8-3(m,4H, CH 2 ), 2.09(m, 5H, CH 2 , CH 3 ) Compound No. 56: (S)-N [ [3- [3-Fluoro-4-[N-l[4-(2-thienylacetyl)]homopiper azinyl] phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-homo- piperazinyl)phenyl]-2-oxo -5-oxazolidinyl]methyl]acetamide and 2-thiophenacetyl- chloride using Method A. δppm (CDC1 3 ) : 7.34(m, IH, Ar-H), 7.18(t, IH, Ar-H), 7.2-6.78(m, 4H, Ar-H), 6.22(t,lH, NH), 4.74(m,lH,CH), 4.2-3.52(m,10H,CH 2 ), 3.52-3.15(m, 4H, CH 2 ), 2.01(m, 5H, CH 2 , CH 3 ) Compound No. 57: (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-nitro)methyl}]homo- piperazinyl]phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-homopiper- azinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl acetamide and 5-nitro -2- thiophencarboxaldehyde using Method B . δppm (CDC1 3 ) : 7.78(s, IH, Ar-H), 7.35(d, IH, Ar-H), 7.04(m,lH, Ar-H), 6.87(m, 2H, Ar-H), 5.99(t, IH, Ar-H), 4.75(m, IH, CH), 4.0(t, IH, CH), 3.85(s, 2H, CH 2 ), 3.52-3.8(m, 3H, CH 2 ), 3.42(m,4H, CH 2 ), 2.9-2.75(m, 4H, CH 2 ), 2.01(m, 5H, CH 2 , CH 3 ) Compound No. 58: (S)-N[[3-[3-Fluoro-4-[N-l[4-(3-furylmethyl)]homopiper- azinyl] phenyl] 2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made with (S)-N-[[3-[3[Fluoro-4-(N-l-homopiper- azinyl)phenyl]-2-oxo -5-oxazolidinyl]methyl]acetamide and 3-furaldehyde using Method B. δppm (MeOD) :7.71 (s,lH, Ar-H), 7.59(s, IH, Ar-H), 7.45(d, IH, Ar-H), 7.12(d, IH, Ar-H), 7.01(t, IH, Ar-H), 6.6(s,lH,Ar-H), 4.53(m, 8H, CH2), 4.1(m,2H,CH2), 3.77(t, IH, CH), 3.75-3.45(m,5H, CH2), 2.19(m,2H, CH2),1.96(s, 3H, CH3) SCHEME-II Compound No. 59: Preparation of (S)-N-[[3-[3-fluoro-4-[N-l{2-furyl-[4-(5- difluoromethyl) methyl}]piperazinyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide. To a solution of (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-formyl)methyl}]ρiρer- azinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide (80 mg, 0.18 mmol) in dichloromethane (4.0 ml) was added diethylamino sulftirtrifluoride (58 mg, 0.35 mmol). The whole reaction mixture was stined at r.t. for 12 hr. TLC of the reaction mixture showed a faster moving spot. It was poured into a container and extracted with dichloromethane. Dichloromethane layer was washed with water, dried over anhydrous sodium sulphate. Solvent was removed. A gummy compound (60 m) was obtained. δppm (CDC1 3 ) :7.44 (d, IH), 7.05 (d, IH), 6.92 (t, IH) 6.62 (m, 2H), 6.36 (m, IH), 6.12 (bs, IH), 4.60 (bs, IH), 3.24-2.95(m,6H), 2.74), 2.74 (bs, 4H) 4.01 (m, IH) 3.68 (m, 3H), 2.00 (s, 3H). Compound No. 74: Preparation of (S)-N-[[3-[3-fluoro-4-[N-l{2-raryl-[4-(5- fluoromethyl) methyl}]piperazinyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide. The title compound was made from (S)-N-[[3-[3-Fluoro-4-[N-l {2-furyl-[4-(5- hydroxymethyl)methyl}]piperazinyl]-2-oxo-5-oxazolidinyl]methyl]acetamide by using the procedure mentioned. Compound No. 60: (S)-N-[[3-[3-Fluoro-4-[N-l-[4-(2-furyI-(5-aldoxime)methyl}] piperazinyl] phenyl]-2-oxo-5-oxazolidinyI]methyl]acetamide. To a solution of 5-formyl furyl derivative (140 mg 0.31 mmol) in dry pyridine was added hydroxylamine hydrochloride (26 mg, 0.38 mmol). The whole reaction mixture was stined at 25°C for 4.0 hr. TLC of the reaction mixture was monitored. A slower moving spot was observed compare to starting compound. Pyridine was removed under reduced pressure and traces of pyridine were removed with toluene to yield title compound of 140 mg. δppm iHNMR (DMSO-d 6 ): 8.70(d,2H),8.08-8.03(m,lH),7.65-7.61 (m,lH), 7.78 (d,lH), 7.24 7.11 (m,2H), 4.70 (d,lH) 4.49 (s,2H), 4.07 (t,lH), 1.82 (s,3H), 3.72 (m, 2H), 3.53-2.88 (m, 9H). Compound No. 61: (S)-N-[[3-[3-FIuoro-4-[N-l[4-{2-furyl(5-aldoxime(methyl-4- (N-carboxyaminophenylacetate) methyl}]piperazinyl]phenyl]-2-oxo-5-oxazolidin- yl] methyl] acetamide The title compound was prepared by using the procedure. Compound No. 62: (S)-N-[[3-[3-Fluoro-4[N-l-[4-{2-furyl-(5-hydrazone)-meth- yl}]-piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide To a solution of 5-formyl furyl derivative (140 mg, 0.31 mmol) in ethanol (4.0 ml) was added hydrazine hydrate (lOOmg) and catalytic amount of cone, sulfuric acid. The whole reaction mixture was stined at 25°C for 48 hr. TLC of the reaction mixture showed no changes. Stirring was continued for another 12 hr. no change in TLC was observed. Solvent was evaporated to dryness and the solid residue was digested with ether to give 100 mg of title compound of m.p. 78-181°C. δppm (CDCl 3 ):δ=7.61 (s,lH), 7.42 (dd,lH), 7.04 (t,lH), 6.92 (t,lH), 6.44 (d,lH), 6.28 (bs,2H), 5.60 (bs,2H), 4.77 (bs,lH), 4.02 (t,lH), 3.77-3.61 (m,8H), 3.10 (bs,lH), 2.71 (bs,lH), 2.02 (s,3H). Compound No. 63: Preparation of (S)-N-[[3-[3-Fluoro-4-[N-l{2-furyI-[4-(5- hydroxymethyl)methyl}] piperazinyl]-2-oxo-5-oxazolidinyl] methyl] acetamide To a solution 5-formyl-2-derivative (100 mg, 0.22 mmol) in ethanol was added Sodium borohydride (solid, 17 mg, 0.44 mmol). The whole reaction mixture was stined at 25°C for 60 hr. TLC of the reaction mixture in chloroform : Methanol (9:1) showed a slower moving spot. The solvent was removed under reduced pressure. The residue was dissoved in chloroform and washed with water, dried over anhydrous sodium sulphate and solvent was removed to give title compound in 70 mg as gum. δppm (CDC1 3 ) : 745 (d,lH), 7.06 (d,lH), 6.94 (d, IH), 6.23 (dd,lH), 6.00 (bs,lH), 4.70 (bs, IH), 4.03 (t, IH), 3.12 (bs, 4H), 2.69 (bs, 4H), 4.62 (s, 2H), 3.76- 3.4 (m, 6H), 2.03 (s, 3H). Compound No. 64: (S)-N-[[3-[3-Fluoro-4-[N-l[4-{2-furyl(5-cyano)methyl}] piperazinyljphenyl] -2-oxo-5-oxazoIidinyl] methyl] acetamide (S)-N-[[3-[3-Fluoro-4-[N-l[4-{2-furyl(5-aldoxime)methyl}]piperazinyl]phen- yl] -2-0X0-5 -oxazolidinyl]methyl] acetamide (6126, 3.5g,0.76 mmol) was taken in CH 2 C1 2 (5 mL) and triethyl amine(1.5g, 1.5 mmol) was added and the r.m. was maintained at -78°C. Triflic anhydride (4.3g, 1.5 mmol) in CH 2 C1 2 (2 mL) was added dropwise after complete addition, the temperature of the reaction mixture was allowed to rise to r.t. in 2 hrs. The r.m. is concentrated under vacuum. H 2 O (10 mL) was added and extracted with CH 2 C1 2 (3x10 mL). The combined organic layer was dried over Na 2 SO 4 , filtered and concentrated to obtain the title compound. NMR(CDC13); 7.44-6.10(m, 6H), 4.74(m,lH), 4.00(t, 2H), 3.73-3.62(m,5H), 3.09-2.68 (m, 8H, ), 2.01(s,3H) Compound No. 65: (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-carboxy)methyl}]- piperazinyl]phenyl]-2-oxo-5-oxazolidmyl]methyl] acetamide The title compound was made using (S)-N-[[3-Fluoro-4-[N-l[4-{2-fiιryl(5- formyl)methyl}]piperazinyl]phenyl] -2-0X0-5 -oxazolidinyl]methyl] acetamide in a solution of freshly prepared Ag 2 O and stirring for 30 min. The r.m. was filtered, acidified to pH 5 and extracted with EtOAc, dried over Na2SO4, filtered and concentrated. δppm (CDC1 3+ MeOD ) 8.01-7.03 (m, 5H), 4.81 (m, IH), 4.07 (t, IH), 3.8-3.3v (m, 5H), 3.0(s,4H), 2.7 (s, 4H) 2.01(s,3H). Compound No. 66: (S)-N-[[3-Fluoro-4-[N-l[5-(l,3-dioxane)-2-furylmethyl]piper- azinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide The title compound was made using (S)-N-[[3-Fluoro-4-[N-l[4-{2-fiιryl(5- formyl)methyl}]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide with 1,3-propane diol and BF 3 etherate using standard literature procedures. Compound No. 67: (S)-N-[[3-Fluoro-4-[N-l [5-(formamido)-2-furylmethyl]- piperazinyl] phenyl] -2-oxo-5-oxazolidinyl] methyl] acetamide The title compound was made reacting (S)-N-[[3-Fluoro-4-|N-l[4-(2-furyl- (5-carboxyethyl)methyl)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide with aqueous ammonia solution followed by wet extraction with ethyl acetate. δppm (CDC1 3+ DMSO-d6 ) 7.46-6.37 (m, 6H), 4.7 (m, IH), 4.0-3.4 (m, 5H), 2.9 (s, 4H), 2.4 (s,4H ), 2.01 (s, 3H). Compound No. 68: (S)-N-[[3-Fluoro-4-[N-l[5-(morpholine-l-carbonyl)-2-furyl- , methyl]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide The title compound was made by reacting (S)-N-[[3-Fluoro-4-[N-l[4-(2-furyl- (5-carboxyethyl)methyl)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide with moφholine using standard literature procedure. Compound No. 69: (S)-N-[[3-Fluoro-4-[N-l[5-(4-(tert butoxy carbonyl)amino piperidine)-2-furylmethyl]piperazinyl]phenyl]-2-oxo-5-oxazolidinyI]methyl] acetamide The title compound was made by reacting (S)-N-[[3-Fluoro-4-[N-l[4-(2-furyl- (5-carboxy)methyl)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide with thionyl chloride and 4-(tert butoxy carbonyl)amino piperidine. While the present invention has been described in terms of its specific embodiments, certain modifications and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.

Claims: CLAIMS: 1. A compound having the structure of Formula I FORMULA I and its pharmaceutically acceptable salts, enantiomers, diastearomers, N- oxides, prodrugs or metabolites, wherein T is five to seven membered heterocyclic ring, aryl, substituted aryl, bound to the ring C with a linker w and the heterocyclic and aryl rings are fiirther substituted by a group represented by R, wherein R is selected from the group consisting of -CN, COR 5 ,COOR 5 , N(Rβ,R7), CON (Re, R 7 ), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH = N-ORio, - C=CH-R 5 , wherein R 5 is selected from the group consisting of H, optionally substituted C 1 -C12, alkyl, C 3 -1 2 , cycloalkyl, aryl, heteroaryl; Rβ and R 7 are independently selected from the group consisting of H, optionally substituted Cι-1 2 alkyl, C 3 -ι 2 cycloalkyl, Ci-β alkoxy; R 8 and R 9 are independently selected from the group consisting of H, Cι_ 6 alkyl, F, CI, Br, C 1 - 12 alkyl substituted with one or more of F, CI, Br, I, ORzi, SRi, N(R< 5 ,R 7 ) wherein R is selected from the group consisting of H, C1-12 alkyl, C 3 - 12 cycloalkyl, Cι- 6 alkoxy, Cι- 6 alkyl substituted with one or more F, CI, Br, I or OH and Re and R 7 are the same as defined earlier, Rio is selected from the group consisting of H, optionally substituted from H, optionally substituted Cι_ι 2 alkyl, C 3 - 512 cycloalkyl, Cι- 6 , alkoxy, Cι- 6 alkyl, aryl, heteroaryl; n is an integer in the range from 0 to 3; X is CH, CH-S, CH-O andN Y and Z are independently selected from the group consisting of hydrogen , Ci _6 alkyl, 03.12 cycloalkyl, C0-.3 bridging group; U and V are independently selected from the group consisting of optionally substituted Ci _6 alkyl , F, CI, Br, Cχ_χ2 alkyl substituted with one or more of F, CI, Br, I, preferably U and V are hydrogen or fluoro; W is selected from the group consisting of CH2, CO, CH2NH, -NHCH2, - CH 2 NHCH 2 , -CH 2 -N (R„) CH 2 - , CH 2 ( Rl l) N -, CH ( R„) , S, CH 2 ( CO), NH wherein R1 1 is optionally substituted with C χ_χ2 alkyl, C3..12 cycloalkyl, Ci .g alkoxy, C ι_g alkyl , aryl , heteroaryl, Ri is selected from the group consisting of - NHC(=O)R 2 wherein R 2 is hydrogen , Cχ_χ2 alkyl, C3_χ2 cycloalkyl, Cι _6 alkoxy, Cχ_β alkyl substituted with one or more of F, CI, Br, I or OH; N(R 3 , Rt) ; -NR 2 C(=S) R 3 : -NR 2 C(=S)SR3 wherein R 2 is the same as defined above and R 3 and R 4 are independently selected from the group consisting of H, Cχ_χ2 alkyl, C3..12 cycloalkyl, Cχ_g alkoxy, C χ.β alkyl substituted with one or more of F, CI, Br, I or OH. A compound having structure of Formula II FORMULA II and its pharmaceutically acceptable salts, enantiomers, diastearomers, N- oxides, prodrugs or metabolites wherein X is CH, CH-S, CH-O and N; Y and Z are independently selected from the group consisting of hydrogen , Ci _6 alkyl, C3.12 cycloalkyl, CQ_3 bridging group; U and V are independently selected from the group consisting of optionally substituted C .β alkyl, F, CI, Br, Ci _χ2 alkyl substituted with one or more of F, CI, Br, I, preferably U and V are hydrogen or fluoro; W is selected from the group consisting of CH2, CO, CH2NH, -NHCH2, -CH 2 NHCH 2 , -CH 2 -N (Rπ) CH 2 - , CH 2 ( RU) N -, CH ( R„) , S, CH 2 ( CO), NH wherein Rχι is optionally substituted with C \.y alkyl, 03.12 cycloalkyl, C\. alkoxy, C 1.g alkyl , aryl , heteroaryl; n is an integer in the range from 0 to 3; and, Q and P are independently selected from the group consisting of -CN, COR 5 , COOR 5 , N (R 6 , R7 ), CON (R g JEL.), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH=N- ORio, C=CH-R 5 , wherein R 5 is selected from the group consisting of H, optionally substituted C j _ 12 alkyl, C 3 ]2 cycloalkyl, aryl, heteroaryl; R and R 7 are independently selected from the group consisting of H, optionally substituted C χ _ 12 alkyl, C 3 _ χ2 cycloalkyl, C 1 6 alkoxy; R 8 and R 9 are independently selected from the group consisting of H, C 1 6 alkyl ,F, CI, Br, C t _ 12 alkyl substituted with one or more of F, CI, Br, I, ORi, SR 4 , wherein R t is selected from the group consisting of H, C1- 12 alkyl, C3. 12 cycloalkyl, Cι_ 6 alkoxy, Cι- 6 alkyl substituted with one or more F, CI, Br, I or OH, NtRβ, R 7 ), Rio is selected from the group consisting of H, optionally substituted C 2 alkyl, C 3 _ 12 cycloalkyl, C 1 6 alkoxy, C 1 _g alkyl , aryl , heteroaryl except W= (CO), Q and P =H, ring C in Formula II is 6-8 membered or of larger size and the larger rings have either two or three carbons between each nitrogen atom, comprising of and may be bridged to form a bicyclic system as shown below, ring C is optionally substituted by Y and Z with alkyl groups, cycloalkyl groups, fluoro group, carboxylic and conesponding esters, amides, substituted alkyls or bridging alkyl groups are as shown below: six membered ring C with X = -CH-(NHRπ), (wherein Rπ is the same as defined earlier) is selected from the group consisting of the following rings; wherein M = Sulphur is shown by compounds Formula III, Formula III wherein P, Q, U, V, X , Y, Z, and n in Formula III are the same as previously defined. 3. A compound selected from the group consisting of 1. (S)-N-[[3-[3-Fluoro-4-[N-l-[4-(2-furoyl) piperazinyl]]phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide 2. (S)-N-[[3-[3-Fluoro-4-[N-l [4- {2-furyl(5-formyl)methyl}]ρiperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl]acetamide 3. (S)-N-[[3-Fluoro-4-[N-l[4-(2-furyl-(5-carboxyethyl)methyl)piperazinyl]phenyl]- 2-oxo-5-oxazolidinyl]methyl]acetamide 4. (S)-N-[[3-Fluoro-4-[N-l[4-(5-bromo-2-furoyl)]piperazinyl]phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide 5. (S)-N-[[3-Fluoro-4-[N-l[4-(5-chloromethyl-2-fiιroyl)piperazinyl]phenyl]-2-oxo- 5 -oxazolidinyl]methyl] acetamide 6. (S)-N-[[3-Fluoro-4-|N-l[4-(5-nifro-2-ftιroyl)piperazinyl]phenyl]-2-oxo-5- oxazolidinyl] methyl] acetamide 7. (S)-N[[3-[3-Fluoro-4-[N- 1 [4- {2-(2-thienyl)dicarbonyl} ]piperazinyl]phenyl]2-oxo- 5-oxazolidinyl]methyl]acetamide 8. (S)-N[[3-[3-Fluoro-4-[N-l[4-(3-furoyl)]piperazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl] acetamide 9. (S)-N[[3-[3-Fluoro-4-P^-l[4-{2-furyl(5-bromo)methyl}]piperazinyl]phenyl ]2- oxo-5-oxazolidinyl]methyl]acetamide 10. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-chloro)methyl}]piperazinyl]phenyl]2- oxo-5-oxazolidinyl]methyl]acetamide 11. (S)-N[[3-[3-Fluoro-4-[N-l [4-(2-flιryhnethyl)]piperazinyl]phenyl]2-oxo-5- oxazolidinyl] methyl] acetamide 12. (S)-N-[[3-[3-Fluoro-4-[N-l[4-(2-thienyhnethyl)]ρiρerazinyl]ρhenyl]-2-oxo-5- oxazolidinyl]methyl]acetamide 13. (S)-N[[3-[3-Fluoro-4-[N-l[4-(2-thienylacetyl)]piperazinyl]ρhenyl]2-oxo-5- oxazolidinyl] methyl] acetamide 14. (S)-N-[[3-[3-Fluoro-4-[N-l [4-{2-thienyl(4-bromo)methyl}]piperazinyl] phenyl]-2 oxo-5-oxazolidinyl]methyl]acetamide 15. (S)-N-[[3-[3-fluoro-4-|N-l-[4-{2-nιryl-(5-nitro)methyl}]piperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl]acetamide. 16. Hydrochloric salt of (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5- nitro)methyl}]piperazinyl] phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 17. Citrate salt of (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-nitro)methyl}]piperazinyl] phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 18. (S)-N[[3-[3-Fluoro-4-[N-l [4-(2-pynolylmethyl)]piperazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl] acetamide 19. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(3-methyl)methyl}]piperazinyl]phenyl]2- oxo-5 -oxazolidinyljmethyl] acetamide 20. (S)-N[[3-[3-Fluoro-4-I r-l[4-(3-furylmethyl)]piperazinyl]phenyl]2-oxo-5- oxazolidinyl] methyl]acetamide 21. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-methyl)methyl}]ρiperazinyl]phenyl]2- oxo-5-oxazolidinyl]methyl]acetamide 22. (S)-N[[3-[3-Fluoro-4-[N-l [4-{2-pynole(l-methyl)methyl}]piperazinyl] phenyl]2- oxo-5-oxazolidinyl]methyl]acetamide 23. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5-nitro)methyl}]piperazinyl]phenyl]2- oxo-5-oxazolidinyl]methyl]acetamide 24. (S)-N[[3-[3-Fluoro-4-[N-l [4-[2-fiιryl{5-(N- thiomoφholinyl)methyl}methyl]piperazinyl] phenyl]2-oxo-5- oxazolidinyljmethyl] acetamide 25. (S)-N[[3-[3-Fluoro-4-[N-l [4-[2-furyl{5-(N- moφholinyl)methyl}methyl]]piperazinyl] phenyl]2-oxo-5- oxazolidinyl]methyl] acetamide 26. (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-acetoxymethyl)methyl}]ρiρerazinyl] phenyl] -2-oxo-5 -oxazolidinyl]methyl] acetamide 27. (S)-N-[[3-Fluoro-4-[N-l[4-{2-thienyl(5-bromo)methyl}]piperazinyl]ρhenyl]-2- oxo-5 -oxazolidinyljmethyl] acetamide 28. (S)-N-[[3-Fluoro-4-|N-l[4-(5-mfro-2-furylmethyl)piperazinyl] phenyl]- 2-oxo oxazolidinyl]methyl]dichloroacetamide 29. (S)-N[[3-[3-Fluoro-4-[N-l[4-(5-nitro-2-thienoyl)]ρiρerazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl]acetamide hydrochloride 30. (S)-N[[3-[3-Fluoro-4-[N-l[4-(2',2'- diphenyl-2' hydroxy acetyl )]piperazinyl]phenyl]2-oxo-5-oxazolidinyl]methyl]acetamide 31. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(5-nitro-2-furoyl)-N-methyl]amino]-3- azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 32. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(3-furoyl)-N-methyl]amino]-3- azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 33. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-( 5-bromo -2-mroyl)-N-methyl] amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5 -oxazolidinyl] methyl] acetamide 34. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(5-nitro-2-thienylmethyl)-N- methyl]amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyl]methyl]acetamide 35. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-( 5-nitro-2-fiιryhnethyl)-N-methyl] amino]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide 36. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(5-formyl-2-furylmethyl)-N-methyl] amino-methyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyljacetamide 37. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(5-carboxyethyl-2-fiιryhnethyl)-N- methyl] aminomethyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyljmethyl] acetamide 38. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(2-tbiopheneacetyl)-N- methyl]aminomethyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyl]methyl] acetamide 39. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(5-nitro-2-thienylmethyl)-N- methyl]amino-methyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyljmethyl] acetamide 40. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(5-nitro-2-furylmethyl)-N- methyl]amino-methyl]-3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5- oxazolidinyl]methyl]acetamide 41. (S)-N-[[3-[4-[4-(N-methyl-N-2futyl(5formyl)methylaminoρiρeridine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl ]methyl]acetamide 42. (S)-N-[[3-[4-[4-(N-methyl-N-(3,5-difluorobenzoyl)aminoρiρeridine- 1 -yl]-3- fluorophenyl] -2-oxo-oxazolidin-5 -yl] methyl] acetamide. 43. (S)-N-[[3-[4-[4-(N-methyl-N-(5-bromo-2-furoyl)aminoρiρeridine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl] methyl]acetamide 44. (S)-N-[[3-[4-[4-(^-methyl-N-(5-mtro-2-furoyl)aminopiρeridine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl ]methyl]acetamide 45. (S)-N-[[3-[4-[4-(N-methyl-N-3- furoyl)aminoρiρeridine-l-yl]-3-fluorophenyl]-2- oxo-oxazolidin-5-yl ]methyl]acetamide. 46. (S)-N-{3-[4-[4-(N-methyl, N- 2-furoyl )aminopiperidine-l-yl]-3-fluorophenyl]-2- oxo-oxazolidin-5-yl methyl]acetamide 47. (S)-N-{3-[4-[4-(N-methyl,2-thiopheneacetyl)aminopiperidine-l-yl]-3- fluorophenyl]-2-oxo oxazolidin-5-yl methyl]acetamide 48. (S)-N-[[3-[4-[4-(N-methyl-N-2fiιryhnethyl) aminopiperidine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl ]methyl]acetamide - 49. (S)-N-[[3-[4-[4-(^-methyl-N-3-ftιryl )aminoρiρeridine-l-yl]-3-fluoroρhenyl]-2- oxo-oxazolidin-5-yl] methyl] acetamide. 50. (S)-N-[[3-[4-[4-(^-methyl-N-2-furyl(5-nitro)methyl)aminopiperidine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl] methyl]acetamide. 51. (S)-N-[[3-[4-[4-(N-methyl-N-2-thienyl(5-nitro)methyl)aminopiperidine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl] methyl] acetamide. 52. (S)-N-[[3-[4-[4-(N-methyl-N-2-thienylmethyl)aminopiρeridine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl ]methyl]acetamide. 53. (S)-N-[[3-[4-[4-(N-methyl-N-(5-methyl-2-thienylmethyl)aminoρiρeridine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl] methyl]acetamide 54. (S)-N-{3-[4-[4-(N-methyl,2-(5-bromo)thienyhnethyl)aminopiperidine-l-yl]-3- fluorophenyl]-2-oxo-oxazolidin-5-yl methyl]acetamide 55. (S)-N[[3-[3-Fluoro-4-| -l[4-{2-fiιryl(5- formyl)methyl}]homopiperazinyl]phenyl]2-oxo-5-oxazolidinyl]methyl]acetamide 56. (S)-N[[3-[3-Fluoro-4-[N-l[4-(2-thienylacetyl)]homoρiperazinyl]phenyl]2-oxo-5- oxazolidinyl]methyl]acetamide 57. (S)-N[[3-[3-Fluoro-4-[N-l[4-{2-thienyl(5- nitro)methyl}]homopiperazinyl]phenyl]2-oxo-5-oxazolidinyl]methyl]acetamide 58. (S)-N[[3-[3-Fluoro-4-[N-l[4-(3-fiιrylmethyl)]homoρiperazinyl]phenyl]2-oxo-5- oxazolidinyfjmethyl] acetamide 59. Preparation of (S)-N-[[3-[3-fluoro-4-[N-l {2-furyl-[4-(5-difluoromethyl) methyl}]piperazinyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide. 60. (S)-N-[[3-[3-Fluoro-4-[N-l-[4-(2-furyl-(5-aldoxime)methyl}] piperazinyl] phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 61. (S)-N-[[3-[3-Fluoro-4-[N-l [4- {2-furyl(5-aldoxime(methyl-4-(N- carboxyaminophenyl acetate) methyl}]piperazinyl]phenyl]-2-oxo-5- oxazolidinyl]methyl] acetamide 62. (S)-N-[[3-[3-Fluoro-4[N-l -[4- {2-furyl-(5-hydrazone)-methyl}]-piperazinyl]- phenyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide 63. Preparation of (S)-N-[[3-[3-Fluoro-4-[N-l {2-furyl-[4-(5-hydroxymethyl)methyl}] piperazinyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 64. (S)-N-[[3-[3-Fluoro-4-| -l[4-{2-fiιryl(5-cyano)methyl}] ρiρerazinyl]ρhenyl] -2- oxo-5 -oxazolidinyl]methyl] acetamide 65. (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-carboxy)methyl}]piperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl] acetamide 66. (S)-N-[[3-Fluoro-4-[N-l [5-(l ,3-dioxane)-2-furylmethyl]piperazinyl]phenyl]-2- oxo-5-oxazolidinyl]methyl] acetamide 67. (S)-N-[[3-Fluoro-4-[N-l[5-(formamido)-2-furyhnethyl]piperazinyl]phenyl]-2- oxo-5 -oxazolidinyljmethyl] acetamide 68. (S)-N-[[3-Fluoro-4-[N-l[5-(moφholine-l-carbonyl)-2- furylmethyl]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide 69. (S)-N-[[3-Fluoro-4-[N-l[5-(4-(tert butoxy carbonyl)amino piperidine)-2- fiιrylmethyl]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide 70. (S)-N-[[3-Fluoro-4-[N-l [4-{(Z)-2-methoxyimino-2-(2- furyl)acetyl}]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 71. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-(2-thiopheneacetyl)-N-methyl]amino]- 3-azabicyclo-[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 72. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-( 5-formyl-2-furylmethyl)-N- methyl] amino]-3 -azabicyclo-[3.1.0]hexane]phenyl] -2-oxo-5 -oxazolidinyl] methyl] acetamide 73. (S)-N-[[3-[3-Fluoro[4-[3-(lα,5α,6α)-6-[N-( 3-thienoyl)-N-methyl]amino]-3- azabicyclo[3.1.0]hexane]phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide 74. (S)-N-[[3-[3-fluoro-4-[N-l {2-furyl-[4-(5-fluoromethyl) methyl} ]piρerazinyl]-2- oxo-5-oxazolidinyl]-methyl]acetamide. 4. A pharmaceutical composition comprising the compound of claims 1, 2, or 3 and a pharmaceutical acceptable carrier. 5. A pharmaceutical composition comprising a pharmaceutically effective amount of compound according to claims 1, 2, or 3, or a physiologically acceptable acid addition salt thereof with a pharmaceutical acceptable carrier for treating microbial infections. 6. A method of treating or preventing microbial infections in a mammal comprising administering to the said mammal, the pharmaceutical composition according to claim 5. A process for preparing a compound of Formula I FORMULA I and its pharmaceutically acceptable salts, enantiomers, diastearomers, N- oxides, prodrugs or metabolites, wherein T is five to seven membered heterocyclic ring, aryl, substituted aryl, bound to the ring C with a linker w and the heterocyclic and aryl rings are further substituted by a group represented by R, wherein R is selected from the group consisting of -CN, COR 5 ,COOR 5 , N(R 6 ,R 7 ), CON (Re, R 7 ), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH = N-ORio, - C=CH-R 5 , wherein R 5 is selected from the group consisting of H, optionally substituted Cι-Cι 2; alkyl, C 3 -ι 2 , cycloalkyl, aryl, heteroaryl, R 6 and R 7 , are independently selected from the group consisting of H, optionally substituted Cι-ι 2 alkyl, C 3 -ι 2 cycloalkyl, Cι- 6 alkoxy; R 8 and R are independently selected from the group consisting of H, Cι- 6 alkyl, F, CI, Br, Cι-ι 2 alkyl substituted with one or more of F, CI, Br, I, OR 4 , SR 4 , N(R 6 ,R 7 ) wherein Rt is selected from the group consisting of H, Cπ alkyl, C 3 .ι 2 cycloalkyl, Cj-e alkoxy, Cι- 6 alkyl substituted with one or more F, CI, Br, I or OH and Re and R are the same as defined earlier, Rio is selected from the group consisting of H, optionally substituted from H, optionally substituted Cι. 12 alkyl, C 3 - 5 ι 2 cycloalkyl, Cι- 6 , alkoxy, Cι_ 6 alkyl, aryl, heteroaryl; n is an integer in the range from 0 to 3; X is CH, CH-S, CH-O and N; Y and Z are independently selected from the group consisting of hydrogen, C _ 6 alkyl, C 3 12 cycloalkyl, C Q 3 bridging group; U and V are independently selected from the group consisting of optionally substituted C χ _ 6 alkyl, F, CI, Br, C 2 alkyl substituted with one or more of F, CI, Br, I, preferably U and V are hydrogen or fluoro; W is selected from the group consisting of CH 2 , CO, CH 2 NH, -NHCH 2 , - CH 2 NHCH 2 , -CH 2 -N (R π ) CH 2 -, CH 2 ( Rll) N-, CH ( Rn), S, CH 2 ( CO), NH wherein R is optionally substituted with C alkyl, C 3 _ 12 cycloalkyl, C 1 6 alkoxy, C 1 6 alkyl, aryl, heteroaryl; and Ri is selected from the group consisting of - NHC(=O)R 2 wherein R 2 is hydrogen, C χ _ 12 alkyl, C 3 cycloalkyl, C j _ 6 alkoxy, C 1 6 alkyl substituted with one or more of F, CI, Br, I or OH; N(R 3 , R4) ; -NR 2 C(=S) R 3 : -NR 2 C(=S)SR3 wherein R 2 is the same as defined above and R3 and R 4 are independently selected from the group consisting of H, C 2 alkyl, C 3 _ 12 cycloalkyl, C 1 6 alkoxy, C 6 alkyl substituted with one or more of F, CI, Br, I or OH, which comprises reacting an amine compound of Formula N FORMULA V with a heterocyclic compound of Formula R-T-W- Rι 2 wherein G in amines of Formula V is defined as NH, CH(NHRι 3 ), -CH-CH 2 NHRι 3 wherein R J3 is H, ethyl, methyl, isopropyl,acetyl, cyclopropyl, alkoxy or acetyl and Y, Z, U, V, Ri, n, R, T and W are the same as defined earlier and Rι 2 is a suitable leaving group selected from the group comprising of fluoro, chloro, bromo, SCH 3 , - SO 2 CH 3 , -SO 2 CF 3 or OC 6 H 5 . 8. A process for preparing a compound of Formula I as claimed in claim 7, wherein W=CH 2 and R-T-W-Rι 2 is a five membered heterocyclic ring with aldehyde group and the compound of Formula I is produced by reductive animation. 9. A process for preparing a compound of Formula I as claimed in claim 7, wherein W = CO and R-T-W-Rι 2 is a five membered heterocyclic ring with carboxylic acid, and amino compound of Formula V is acylated with activated esters in presence of condensing agents comprising 1,3-dicyclo- hexylcarbodiimide (DCC) and l-(3-dimethylaminopropyl)-3-ethylcarbo- diimide (EDC). 0. A process for the preparation of compound of Formula II FORMULA II wherein n is an integer in the range from 0 to 3; X is CH, CH-S, CH-O and N; Y and Z are independently selected from the group consisting of hydrogen, C j 6 alkyl, C 3 12 cycloalkyl, C M bridging group; U and V are independently selected from the group consisting of optionally substituted C w alkyl, F, CI, Br, C χ _ χ2 alkyl substituted with one or more of F, CI, Br, I, preferably U and V are hydrogen or fluoro; W is selected from the group consisting of CH 2 , CO, CH 2 NH, -NHCH 2 , - CH 2 NHCH 2 , -CH 2 -N (Rπ) CH 2 -, CH 2 ( Rll) N-, CH ( R„), S, CH 2 ( CO), NH wherein R n is optionally substituted with C 12 alkyl, C 3 _ 12 cycloalkyl, C j _ 6 alkoxy, C 1 6 alkyl, aryl, heteroaryl; and Q and P are independently selected from the group consisting of -CN, COR 5 , COOR 5 , N (R 6 , R7 ), CON (R g JL,), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH=N- ORio, C=CH-R 5 , wherein R 5 is selected from the group consisting of H, optionally substituted C χ _ 12 alkyl, C 3 cycloalkyl, aryl, heteroaryl; Re and R 7 are independently selected from the group consisting of H, optionally substituted C M2 alkyl, C 3 _ 12 cycloalkyl, C χ _ 6 alkoxy; R and R 9 are independently selected from the group consisting of H, C χ _ 6 alkyl,F, CI, Br, C χ χ2 alkyl substituted with one or more of F, CI, Br, I, OR 4 , SR 4 , wherein Ri is the same as defined before, N(Re, R 7 ), Rio is selected from the group consisting of H, optionally substituted C 2 alkyl, C 3 _ 12 cycloalkyl, C 1 6 alkoxy, C 1 6 alkyl, aryl, heteroaryl except W= (CO), Q and P =H. Ring C in Formula II is 6-8 membered or of larger size and the larger rings have either two or three carbons between each nitrogen atom, comprising of and may be bridged to form a bicyclic system as shown below, ring C is optionally substituted by Y and Z with alkyl groups, cycloalkyl groups, fluoro group, carboxylic and conesponding esters, amides, substituted alkyls or bridging alkyl groups are as shown below: six membered ring C with X = -CH-(NHRπ), (wherein Rn is the same as defined earlier) is selected from the group consisting of the following rings; wherein M = Sulphur is shown by compounds of Formula III, FORMULA HI ill wherein P, Q, U, V, X, Y, Z, W and n in Formula III are the same as previously defined, wherein the process comprising reacting a compound of Formula N FORMULA V with a compound of Formula NI FORMULA VI wherein P, Q, Rι 2 , Y, Z, G, n, U and N are the same as defined earlier. 11. A process for preparing a compound of Formula II as claimed in claim 10, in a suitable solvent selected from the group consisting of dimethylformamide, dimethylacetamide, ethanol or ethylene glycol at a suitable temperature in the range of -70°C to 180°C in the presence of a suitable base selected from the group consisting of triethyl amine, diisopropyl amine, potassium carbonate and sodium bicarbonate. 12. A process of preparing a compound of Formula II as claimed in claim 10 wherein Formula NI is fiiralehyde and reductive alkylation of the amine of Formula N is performed with a reducing agent. 13. A process for preparing a compound of Formula II as claimed in claim 10 wherein Formula NI is furoic acid. 14. A process for preparing a compound of Formula II as claimed in claim 10 wherein the compounds of Formula II having carbonyl link are prepared by reacting heteroaromatic compound of the Formula NI including Ν- methyl pynole with the intermediate amine of Formula N in the presence of triphosgene or phosgene and carbonyl linkers are introduced between heteroaromatic compound comprising reacting 3- bromothiophene and amine of Formula N with carbon monoxide and the catalyst is selected from the group consisting of Pd (PPli 3 ) 2 Cl 2 and extended chain pynoles having dicarbonyl linkers are obtained by treatment of oxalyl chloride and amine of the Formula N. 15. A process for preparing a compound of Formula NIII FORMULA VIII wherein n is an integer in the range from 0 to 3; X is CH, CH-S, CH-O and N; Y and Z are independently selected from the group consisting of hydrogen, C χ 6 alkyl, C 3 . 12 cycloalkyl, C Q 3 bridging group; U and V are independently selected from the group consisting of optionally substituted C 1 6 alkyl, F, CI, Br, C χ χ2 alkyl substituted with one or more of F, CI, Br, I, preferably U and V are hydrogen or fluoro; W is selected from the group consisting of CH 2 , CO, CH 2 NH, -NHCH 2 , - CH 2 NHCH 2 , -CH 2 -N (Rn) CH 2 -, CH 2 ( Rll) N-, CH ( Rn), S, CH 2 ( CO), NH wherein R π is optionally substituted with C χ χ2 alkyl, C 3 _ χ2 cycloalkyl, C χ _ 6 alkoxy, C 1 6 alkyl, aryl, heteroaryl; Q and P are independently selected from the group consisting of -CN, COR 5 , COOR 5 , N (R 6 , R7 ), CON (R 6 ,R 7 ), CH 2 NO 2 , NO 2 , CH 2 R 8 , CHR 9 , -CH=N- ORio, C=CH-R 5 , wherein R 5 is selected from the group consisting of H, optionally substituted C χ _ 12 alkyl, C 3 12 cycloalkyl, aryl, heteroaryl; R 6 and R 7 are independently selected from the group consisting of H, optionally substituted C 2 alkyl, C 3 Λ cycloalkyl, C j _ 6 alkoxy; R 8 and R 9 are independently selected from the group consisting of H, C l g alkyl,F, CI, Br, C j 12 alkyl substituted with one or more of F, CI, Br, I, OR 4 , SR 4 , wherein R_t is the same as defined before, N(Re, R ), Rio is selected from the group consisting of H, optionally substituted C 1 12 alkyl, C 3 12 cycloalkyl, C χ 6 alkoxy, C χ 6 alkyl, aryl, heteroaryl except W= (CO), Q and P =H; M = Sulphur is shown by compounds of Formula III FORMULA HI and R 15 is the same as Q defined earlier, comprising converting a compound of Formula Nil FORMULA VII wherein in U, N, Y, Z, X, W, P, n and M are the same as defined earlier and are Rι 4 is any group which can be converted to group Rι 5 in one to five steps. 16. A process for preparing a compound of Formula XI FORMULA XI (Ri 6 = -CH 2 F or -CH 2 F 2 ) by reacting a compound of Formula IX FORMULA IX with sodium borohydride to produce a compound of Formula X FORMULA X and further reacting this compound with diethylamino sulfurtrifluoride to produce compound of Formula XI. 17. A process for preparing a compound of Formula XII FORMULA XH wherein Rπ = ^=N-OH which comprises reacting (S)-N-[[3-Fluoro-4-[N- 1 [4- {2-furyl(5-formyl)methyl} ]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]- methyl] acetamide of Formula IX FORMULA IX with hydroxylamine. 18. A process for preparing a compound of Formula XII FORMULA XO wherein Rπ = which comprises reacting (S)-N-[[3-[3-Fluoro-4[N- 1 -[4- {2-furyl-(5 -hydrazone)-methyl} ] -piperazinyl] -phenyl] -2-oxo-5 - oxazolidinyl]-methyl]acetamide with hydrazine hydrate. 19. A process for preparing a compound of Formula XII FORMULA Xπ wherein Rπ which comprises reacting (S)-N- [[3-[3-Fluoro-4-|N-l-[4-(2-furyl-(5-aldoxime)methyl}] piperazinyl] phenyl]- 2-oxo-5-oxazolidinyl]methyl] acetamide with isocyanate. 20. A process for preparing a compound of Formula XII o w Ri 17 o NHCOCH 3 FORMULA Xπ wherein Rπ = CN which comprises reacting (S)-N-[[3-[3-Fluoro-4-[N-l[4-{2- furyl(5-cyano)methyl}]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acet- amide with trifilic anhydride and triethylamine. 21. A process for preparing a compound of Formula XII JTORMULAXΠ wherein R17 = ^ _J which comprises reacting (S)-N-[[3-Fluoro-4-[N-l[5- (l,3-dioxane)-2-furyhnethyl]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]meth- yl]acetamide with 1,3-propane diol and BF 3 etherate. 22. A process for the preparation of the compound of Formula XIV FORMULA XIV O wherein R = U 18 ^C„ H 2 which comprises reacting (S)-N-[[3-Fluoro-4-[N-l[4-{2-fiιryl(5-formyl)- methyl}] piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula IX FORMULA IX with Ag 2 O to produce (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-carboxy)meth- yl}]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula Xiπ followed by reacting (S)-N-[[3-Fluoro-4-[N-l[4-(2-furyl- (5-carboxy- ethyl)methyl)piperazinyl] phenyl]- 2-oxo-5-oxazolidinyl]methyl] acetamide of FORMULA Xffl with aqueous ammonia to produce Formula XIV. 23. A process for the preparation of the compound of Formula XIV FORMULA XIV O I I . . wherein R 18 = -^ N O \__ which comprises reacting (S)-N-[[3-Fluoro-4-[N-l[4-{2-fiιryl(5-formyl)- methyl}] piperazinyl]phenyI]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula IX FORMULA IX with Ag 2 O to produce (S)-N-[[3-Fluoro-4-|N-l[4-{2-furyl(5-carboxy)meth- yl}]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula XIII followed by reacting (S)-N- [[3 -Fluoro-4- [N-l[4-(2-furyl- (5-carboxy- ethyl)methyl)piperazinyl] phenyl]- 2-oxo-5-oxazolidinyl]methyl] acetamide of Formula Xm FORMULA Xffl with thionyl chloride to produce Formula XIV. 24. A process for the preparation of the compound of Formula XIV FORMULA XIV O I I wherein Rι 8 = S * O-HBOC which comprises reacting (S)-N-[[3-Fluoro-4-[N-l[4-{2-furyl(5-formyl)- methyl}] piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula IX FORMULA IX with Ag 2 O to produce (S)-N-[[3-Fluoro-4-IN-l[4-{2-furyl(5-carboxy)meth- yl}]piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide of Formula Xiπ followed by reacting (S)-N-[[3-Fluoro-4-[N-l[4-(2-furyl- (5-carboxy- ethyl)methyl)piperazinyl] phenyl]- 2-oxo-5-oxazolidinyl]methyl] acetamide of Formula XIII FORMULA XuT with moφholine in the presence of oxalyl chloride to produce Formula XIV.

Inventors: ARORA SUDERSHAN K, DAS BISWAJIT, MEHTA ANITA, RATTAN ASHOK, RAY ABHIJIT, RUDRA SONALI, ARORA, SUDERSHAN, K., DAS, BISWAJIT, MEHTA, ANITA, RATTAN, ASHOK, RAY, ABHIJIT, RUDRA, SONALI
Applicants: ARORA SUDERSHAN K, DAS BISWAJIT, MEHTA ANITA, RANBAXY LAB LTD, RATTAN ASHOK, RAY ABHIJIT, RUDRA SONALI, ARORA, SUDERSHAN, K., DAS, BISWAJIT, MEHTA, ANITA, RANBAXY LABORATORIES LIMITED, RATTAN, ASHOK, RAY, ABHIJIT, RUDRA, SONALI
Application year: 2001
Main classification: C07D413
IPC codes: A61K31, A61P31, A61P43, C07D263, C07D413