MOLECULES FOR DISEASE DETECTION AND TREATMENT

Abstract: The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.

Description: MOLECULES FOR DISEASE DETECTION AND TREATMENT TECHNICAL FIELD The present invention relates to molecules for disease detection and treatment and to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases associated with, as well as effects of exogenous compounds on, the expression of molecules for disease detection and treatment. BACKGROUND OF THE INVENTION The human genome is comprised of thousands of genes, many encoding gene products that function in the maintenance and growth of the various cells and tissues in the body. Aberrant expression or mutations in these genes and their products is the cause of, or is associated with, a variety of human diseases such as cancer and other cell proliferative disorders. The identification of these genes and their products is the basis of an ever-expanding effort to find markers for early detection of diseases, and targets for their prevention and treatment. For example, cancer represents a type of cell proliferative disorder that affects nearly every tissue in the body. A wide variety of molecules, either aberrantly expressed or mutated, can be the cause of, or involved with, various cancers because tissue growth involves complex and_ordered patterns of cell proliferation, cell differentiation, and apoptosis. Cell proliferation must be regulated to maintain both the number of cells and their spatial organization. This regulation depends upon the appropriate expression of proteins which control cell cycle progression in response to extracellular signals such as growth factors and other mitogens, and intracellular cues such as DNA damage or nutrient starvation. Molecules which directly or indirectly modulate cell cycle progression fall into several categories, including growth factors and their receptors, second messenger and signal transduction proteins, oncogene products, tumor-suppressor proteins, and mitosis-promoting factors. Aberrant expression or mutations in any of these gene products can result in cell proliferative disorders such as cancer. Oncogenes are genes generally derived from normal genes that, through abnormal expression or mutation, can effect the transformation of a normal cell to a malignant one (oncogenesis). Oncoproteins, encoded by oncogenes, can affect cell proliferation in a variety of ways and include growth factors, growth factor receptors, intracellular signal transducers, nuclear transcription factors, and cell-cycle control proteins. In contrast, tumor-suppressor genes are involved in inhibiting cell proliferation. Mutations which cause reduced or loss of function in tumor-suppressor genes result in aberrant cell proliferation and cancer. Thus a wide variety of genes and their products have been found that are associated with cell proliferative disorders such as cancer, but many more may exist that are yet to be discovered. DNA-based arrays can provide a simple way to explore the expression of a single polymorphic gene or a large number of genes. When the expression of a single gene is explored, DNA-based arrays are employed to detect the expression of specific gene variants. For example, a p53 tumor suppressor gene array is used to determine whether individuals are carrying mutations that predispose them to cancer. A cytochrome p450 gene array is useful to determine whether individuals have one of a number of specific mutations that could result in increased drug metabolism, drug resistance or drug toxicity. DNA-based array technology is especially relevant for the rapid screening of expression of a large number of genes. There is a growing awareness that gene expression is affected in a global fashion. A genetic predisposition, disease or therapeutic treatment may affect, directly or indirectly, the expression of a large number of genes. In some cases the interactions may be expected, such as when the genes are part of the same signaling pathway. In other cases, such as when the genes participate in separate signaling pathways, the interactions may be totally unexpected. Therefore, DNA-based arrays can be used to investigate how genetic predisposition, disease, or therapeutic treatment affects the expression of a large number of genes. The discovery of new molecules for disease detection and treatment satisfies a need in the art by providing new compositions which are useful in the diagnosis, study, prevention, and treatment of diseases associated with, as well as effects of exogenous compounds on, the expression of molecules for disease detection and treatment. SUMMARY OF THE INVENTION The present invention relates to human disease detection and treatment molecule polynucleotides (mddt) as presented in the Sequence Listing. The mddt uniquely identify genes encoding structural, functional, and regulatory disease detection and treatment molecules. The invention provides an isolated polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:l-252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In one alternative, the polynucleotide comprises a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252. In another alternative, the polynucleotide comprises at least 30 contiguous nucleotides of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1 -252; b) a polynucleotide comprising a naturally occurring polynucleotide comprising a polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In another alternative, the polynucleotide comprises at least 60 contiguous nucleotides of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; b) a polynucleotide comprising a naturally occurring polynucleotide comprising a polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The invention further provides a composition for the detection of expression of disease detection and treatment molecule polynucleotides comprising at least one isolated polynucleotide comprising a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1 -252; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d); and a detectable label. The invention also provides a method for detecting a target polynucleotide in a sample, said target polynucleotide having a polynucleotide sequence of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence of a polynucleotide selected from the group consisting of SEQ ID NO: 1-252; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The method comprises a) amplifying said target polynucleotide or fragment thereof using polymerase chain reaction amplification, and b) detecting the presence or absence of said amplified target polynucleotide or fragment thereof, and, optionally, if present, the amount thereof. The invention also provides a method for detecting a target polynucleotide in a sample, said target polynucleotide having a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The method comprises a) hybridizing the sample with a probe comprising at least 20 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target polynucleotide, and b) detecting the presence or absence of said hybridization complex, and, optionally, if present, the amount thereof. In one alternative, the invention provides a composition comprising a target polynucleotide of the method, wherein said probe comprises at least 30 contiguous nucleotides. In one alternative, the invention provides a composition comprising a target polynucleotide of the method, wherein said probe comprises at least 60 contiguous nucleotides. The invention further provides a recombinant polynucleotide comprising a promoter sequence operably linked to an isolated polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In one alternative, the invention provides a cell transformed with the recombinant polynucleotide. In another alternative, the invention provides a transgenic organism comprising the recombinant polynucleotide. The invention also provides a method for producing a disease detection and treatment polypeptide, the method comprising a) culturing a cell under conditions suitable for expression of the disease detection and treatment polypeptide, wherein said cell is transformed with a recombinant polynucleotide, said recombinant polynucleotide comprising an isolated polynucleotide selected from the group consisting of i) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; ii) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv), and b) recovering the disease detection and treatment polypeptide so expressed. The invention additionally provides a method wherein the polypeptide has an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The invention also provides an isolated disease detection and treatment polypeptide (MDDT) encoded by at least one polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252. The invention further provides a method of screening for a test compound that specifically binds to the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The method comprises a) combining the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506 with at least one test compound under suitable conditions, and b) detecting binding of the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506 to the test compound, thereby identifying a compound that specifically binds to the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The invention further provides a microarray wherein at least one element of the microarray is an isolated polynucleotide comprising at least 30 contiguous nucleotides of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1 -252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The invention also provides a method for generating a transcript image of a sample which contains polynucleotides. The method comprises a) labeling the polynucleotides of the sample, b) contacting the elements of the microarray with the labeled polynucleotides of the sample under conditions suitable for the formation of a hybridization complex, and c) quantifying the expression of the polynucleotides in the sample. Additionally, the invention provides a method for screening a compound for effectiveness in altering expression of a target polynucleotide, wherein said target polynucleotide comprises a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1 -252; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The method comprises a) exposing a sample comprising the target polynucleotide to a compound, b) detecting altered expression of the target polynucleotide, and c) comparing the expression of the target polynucleotide in the presence of varying amounts of the compound and in the absence of the compound. The invention further provides a method for assessing toxicity of a test compound, said method comprising a) treating a biological sample containing nucleic acids with the test compound; b) hybridizing the nucleic acids of the treated biological sample with a probe comprising at least 20 contiguous nucleotides of a polynucleotide selected from the group consisting of i) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; ii) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv). Hybridization occurs under conditions whereby a specific hybridization complex is formed between said probe and a target polynucleotide in the biological sample, said target polynucleotide comprising a polynucleotide sequence of a polynucleotide selected from the group consisting of i) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1 -252; ii) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252; iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv), and alternatively, the target polynucleotide comprises a polynucleotide sequence of a fragment of a polynucleotide selected from the group consisting of i-v above; c) quantifying the amount of hybridization complex; and d) comparing the amount of hybridization complex in the treated biological sample with the amount of hybridization complex in an untreated biological sample, wherein a difference in the amount of hybridization complex in the treated biological sample is indicative of toxicity of the test compound. The invention further provides an isolated polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. In one alternative, the invention provides an isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The invention further provides an isolated polynucleotide encoding a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253- 506. In one alternative, the polynucleotide encodes a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. In another alternative, the polynucleotide comprises a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1-252. Additionally, the invention provides an isolated antibody which specifically binds to a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The invention further provides a composition comprising a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:253- 506, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and a pharmaceutically acceptable excipient. In one embodiment, the composition comprises a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The invention additionally provides a method of treating a disease or condition associated with decreased expression of functional MDDT, comprising administering to a patient in need of such treatment the composition. The invention also provides a method for screening a compound for effectiveness as an agonist of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The method comprises a) exposing a sample comprising the polypeptide to a compound, and b) detecting agonist activity in the sample. In one alternative, the invention provides a composition comprising an agonist compound identified by the method and a pharmaceutically acceptable excipient. In another alternative, the invention provides a method of treating a disease or condition associated with decreased expression of functional MDDT, comprising administering to a patient in need of such treatment the composition. Additionally, the invention provides a method for screening a compound for effectiveness as an antagonist of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO: 253-506, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The method comprises a) exposing a sample comprising the polypeptide to a compound, and b) detecting antagonist activity in the sample. In one alternative, the invention provides, a composition comprising an antagonist compound identified by the method and a pharmaceutically acceptable excipient. In another alternative, the invention provides a method of treating a disease or condition associated with overexpression of functional MDDT, comprising administering to a patient in need of such treatment the composition. The invention further provides a method of screening for a compound that modulates the activity of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. The method comprises a) combining the polypeptide with at least one test compound under conditions permissive for the activity of the polypeptide, b) assessing the activity of the polypeptide in the presence of the test compound, and c) comparing the activity of the polypeptide in the presence of the test compound with the activity of the polypeptide in the absence of the test compound, wherein a change in the activity of the polypeptide in the presence of the test compound is indicative of a compound that modulates the activity of the polypeptide. DESCRIPTION OF THE TABLES Table 1 shows the sequence identification numbers (SEQ ID NO:s) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with the sequence identification numbers (SEQ ID NO:s) and open reading frame identification numbers (ORF IDs) corresponding to polypeptides encoded by the template ID. Table 2 shows the sequence identification numbers (SEQ ID NO:s) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with their GenBank hits (GI Numbers), probability scores, and functional annotations corresponding to the GenBank hits. Table 3 shows the sequence identification numbers (SEQ ID NO:s) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with polynucleotide segments of each template sequence as defined by the indicated "start" and "stop" nucleotide positions. The reading frames of the polynucleotide segments and the Pfam hits, Pfam descriptions, and E-values corresponding to the polypeptide domains encoded by the polynucleotide segments are indicated. Table 4 shows the sequence identification numbers (SEQ ID NO:s) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with polynucleotide segments of each template sequence as defined by the indicated "start" and "stop" nucleotide positions. The reading frames of the polynucleotide segments are shown, and the polypeptides encoded by the polynucleotide segments constitute either signal peptide (SP) or transmembrane (TM) domains, as indicated. The membrane topology of the encoded polypeptide sequence is indicated, the N-terminus (N) listed as being oriented to either the cytosolic (N in) or non- cytosolic (N out) side of the cell membrane or organelle. Table 5 shows the sequence identification numbers (SEQ ID NO:s) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with component sequence identification numbers (component IDs) corresponding to each template. The component sequences, which were used to assemble the template sequences, are defined by the indicated "start" and "stop" nucleotide positions along each template. Table 6 shows the tissue distribution profiles for the templates of the invention. Table 7 shows the sequence identification numbers (SEQ ID NO:s) corresponding to the polypeptides of the present invention, along with the reading frames used to obtain the polypeptide segments, the lengths of the polypeptide segments, the "start" and "stop" nucleotide positions of the polynucleotide sequences used to define the encoded polypeptide segments, the GenBank hits (GI Numbers), probability scores, and functional annotations corresponding to the GenBank hits. Table 8 summarizes the bioinformatics tools which are useful for analysis of the polynucleotides of the present invention. The first column of Table 8 lists analytical tools, programs, and algorithms, the second column provides brief descriptions thereof, the third column presents appropriate references, all of which are incorporated by reference herein in their entirety, and the fourth column presents, where applicable, the scores, probability values, and other parameters used to evaluate the strength of a match between two sequences (the higher the score, the greater the homology between two sequences). DETAILED DESCRIPTION OF THE INVENTION Before the nucleic acid sequences and methods are presented, it is to be understood that this invention is not limited to the particular machines, methods, and materials described. Although particular embodiments are described, machines, methods, and materials similar or equivalent to these embodiments may be used to practice the invention. The preferred machines, methods, and materials set forth are not intended to limit the scope of the invention which is limited only by the appended claims. The singular forms "a", "an", and "the" include plural reference unless the context clearly dictates otherwise. All technical and scientific terms have the meanings commonly understood by one of ordinary skill in the art. All publications are incorporated by reference for the purpose of describing and disclosing the cell lines, vectors, and methodologies which are presented and which might be used in connection with the invention. Nothing in the specification is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention. Definitions As used herein, the lower case "mddt" refers to a nucleic acid sequence, while the upper case "MDDT" refers to an amino acid sequence encoded by mddt. A "full-length" mddt refers to a nucleic acid sequence containing the entire coding region of a gene endogenously expressed in human tissue. "Adjuvants" are materials such as Freund's adjuvant, mineral gels (aluminum hydroxide), and surface active substances (lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, and dinitrophenol) which may be administered to increase a host's immunological response. "Allele" refers to an alternative form of a nucleic acid sequence. Alleles result from a "mutation," a change or an alternative reading of the genetic code. Any given gene may have none, one, or many allelic forms. Mutations which give rise to alleles include deletions, additions, or substitutions of nucleotides. Each of these changes may occur alone, or in combination with the others, one or more times in a given nucleic acid sequence. The present invention encompasses allelic mddt. "Amino acid sequence" refers to a peptide, a polypeptide, or a protein of either natural or synthetic origin. The amino acid sequence is not limited to the complete, endogenous amino acid sequence and may be a fragment, epitope, variant, or derivative of a protein expressed by a nucleic acid sequence. "Amplification" refers to the production of additional copies of a sequence and is carried out using polymerase chain reaction (PCR) technologies well known in the art. "Antibody" refers to intact molecules as well as to fragments thereof, such as Fab, F(ab') 2 , and Fv fragments, which are capable of binding the epitopic determinant. Antibodies that bind MDDT polypeptides can be prepared using intact polypeptides or using fragments containing small peptides of interest as the immunizing antigen. The polypeptide or peptide used to immunize an animal (e.g., a mouse, a rat, or a rabbit) can be derived from the translation of RNA, or synthesized chemically, and can be conjugated to a carrier protein if desired. Commonly used carriers that are chemically coupled to peptides include bovine serum albumin, thyroglobulin, and keyhole limpet hemocyanin (KLH). The coupled peptide is then used to immunize the animal. "Antisense sequence" refers to a sequence capable of specifically hybridizing to a target sequence. The antisense sequence may include DNA, RNA, or any nucleic acid mimic or analog such as peptide nucleic acid (PNA); oligonucleotides having modified backbone linkages such as phosphorothioates, methylphosphonates, or benzylphosphonates; oligonucleotides having modified sugar groups such as 2'-methoxyethyl sugars or 2'-methoxyethoxy sugars; or oligonucleotides having modified bases such as 5-methyl cytosine, 2'-deoxyuracil, or 7-deaza-2'-deoxyguanosine. "Antisense sequence" refers to a sequence capable of specifically hybridizing to a target sequence. The antisense sequence can be DNA, RNA, or any nucleic acid mimic or analog. "Antisense technology" refers to any technology which relies on the specific hybridization of an antisense sequence to a target sequence. A "bin" is a portion of computer memory space used by a computer program for storage of data, and bounded in such a manner that data stored in a bin may be retrieved by the program. "Biologically active" refers to an amino acid sequence having a structural, regulatory, or biochemical function of a naturally occurring amino acid sequence. "Clone joining" is a process for combining gene bins based upon the bins' containing sequence information from the same clone. The sequences may assemble into a primary gene transcript as well as one or more splice variants. "Complementary" describes the relationship between two single-stranded nucleic acid sequences that anneal by base-pairing (5'-A-G-T-3' pairs with its complement 3'-T-C-A-5'). A "component sequence" is a nucleic acid sequence selected by a computer program such as PHRED and used to assemble a consensus or template sequence from one or more component sequences. A "consensus sequence" or "template sequence" is a nucleic acid sequence which has been assembled from overlapping sequences, using a computer program for fragment assembly such as the GELVIEW fragment assembly system (Genetics Computer Group (GCG), Madison WI) or using a relational database management system (RDMS). "Conservative amino acid substitutions" are those substitutions that, when made, least interfere with the properties of the original protein, i.e., the structure and especially the function of the protein is conserved and not significantly changed by such substitutions. The table below shows amino acids which may be substituted for an original amino acid in a protein and which are regarded as conservative substitutions. Original Residue Conservative Substitution Ala Gly, Ser Arg His, Lys Asn Asp, Gin, His Asp Asn, Glu Cys Ala, Ser Gin Asn, Glu, His Glu Asp, Gin, His Gly Ala His Asn, Arg, Gin, Glu He Leu, Val Leu He, Val Lys Arg, Gin, Glu Met Leu, He Phe His, Met, Leu, Trp, Tyr Ser Cys, Thr Thr Ser, Val Trp Phe, Tyr Tyr His, Phe, Trp Val He, Leu, Thr Conservative substitutions generally maintain (a) the structure of the polypeptide backbone in the area of the substitution, for example, as a beta sheet or alpha helical conformation, (b) the charge or hydrophobicity of the molecule at the target site, or (c) the bulk of the side chain. "Deletion" refers to a change in either a nucleic or amino acid sequence in which at least one nucleotide or amino acid residue, respectively, is absent. "Derivative" refers to the chemical modification of a nucleic acid sequence, such as by replacement of hydrogen by an alkyl, acyl, amino, hydroxyl, or other group. "Differential expression" refers to increased or upregulated; or decreased, downregulated, or absent gene or protein expression, determined by comparing at least two different samples. Such comparisons may be carried out between, for example, a treated and an untreated sample, or a diseased and a normal sample. The terms "element" and "array element" refer to a polynucleotide, polypeptide, or other chemical compound having a unique and defined position on a microarray. "E-value" refers to the statistical probability that a match between two sequences occurred by chance. "Exon shuffling" refers to the recombination of different coding regions (exons). Since an exon may represent a structural or functional domain of the encoded protein, new proteins may be assembled through the novel reassortment of stable substructures, thus allowing acceleration of the evolution of new protein functions. A "fragment" is a unique portion of mddt or MDDT which is identical in sequence to but shorter in length than the parent sequence. A fragment may comprise up to the entire length of the defined sequence, minus one nucleotide/amino acid residue. For example, a fragment may comprise from 10 to 1000 contiguous amino acid residues or nucleotides. A fragment used as a probe, primer, antigen, therapeutic molecule, or for other purposes, may be at least 5, 10, 15, 16, 20, 25, 30, 40, 50, 60, 75, 100, 150, 250 or at least 500 contiguous amino acid residues or nucleotides in length. Fragments may be preferentially selected from certain regions of a molecule. For example, a polypeptide fragment may comprise a certain length of contiguous amino acids selected from the first 250 or 500 amino acids (or first 25% or 50%) of a polypeptide as shown in a certain defined sequence. Clearly these lengths are exemplary, and any length that is supported by the specification, including the Sequence Listing and the figures, may be encompassed by the present embodiments. A fragment of mddt comprises a region of unique polynucleotide sequence that specifically identifies mddt, for example, as distinct from any other sequence in the same genome. A fragment of mddt is useful, for example, in hybridization and amplification technologies and in analogous methods that distinguish mddt from related polynucleotide sequences. The precise length of a fragment of mddt and the region of mddt to which the fragment corresponds are routinely determinable by one of ordinary skill in the art based on the intended purpose for the fragment. A fragment of MDDT is encoded by a fragment of mddt. A fragment of MDDT comprises a region of unique amino acid sequence that specifically identifies MDDT. For example, a fragment of MDDT is useful as an immunogenic peptide for the development of antibodies that specifically recognize MDDT. The precise length of a fragment of MDDT and the region of MDDT to which the fragment corresponds are routinely determinable by one of ordinary skill in the art based on the intended purpose for the fragment. A "full length" nucleotide sequence is one containing at least a start site for translation to a protein sequence, followed by an open reading frame and a stop site, and encoding a "full length" polypeptide. "Hit" refers to a sequence whose annotation will be used to describe a given template. Criteria for selecting the top hit are as follows: if the template has one or more exact nucleic acid matches, the top hit is the exact match with highest percent identity. If the template has no exact matches but has significant protein hits, the top hit is the protein hit with the lowest E-value. If the template has no significant protein hits, but does have significant non-exact nucleotide hits, the top hit is the nucleotide hit with the lowest E-value. "Homology" refers to sequence similarity either between a reference nucleic acid sequence and at least a fragment of an mddt or between a reference amino acid sequence and a fragment of an MDDT. "Hybridization" refers to the process by which a strand of nucleotides anneals with a complementary strand through base pairing. Specific hybridization is an indication that two nucleic acid sequences share a high degree of identity. Specific hybridization complexes form under defined annealing conditions, and remain hybridized after the "washing" step. The defined hybridization conditions include the annealing conditions and the washing step(s), the latter of which is particularly important in determining the stringency of the hybridization process, with more stringent condiUons allowing less non-specific binding, i.e., binding between pairs of nucleic acid probes that are not perfectly matched. Permissive conditions for annealing of nucleic acid sequences are routinely determinable and may be consistent among hybridization experiments, whereas wash conditions may be varied among experiments to achieve the desired stringency. Generally, stringency of hybridization is expressed with reference to the temperature under which the wash step is carried out. Generally, such wash temperatures are selected to be about 5°C to 20°C lower than the thermal melting point (T m ) for the specific sequence at a defined ionic strength and pH. The T m is the temperature (under defined ionic strength and pH) at which 50% of the target sequence hybridizes to a perfectly matched probe. An equation for calculating T m and conditions for nucleic acid hybridization is well known and can be found in Sambrook et al., 1989, Molecular Cloning: A Laboratory Manual. 2 nd ed., vol. 1-3, Cold Spring Harbor Press, Plainview NY; specifically see volume 2, chapter 9. High stringency conditions for hybridization between polynucleotides of the present invention include wash conditions of 68°C in the presence of about 0.2 x SSC and about 0.1% SDS, for 1 hour. Alternatively, temperatures of about 65°C, 60°C, or 55°C may be used. SSC concentration may be varied from about 0.2 to 2 x SSC, with SDS being present at about 0.1 %. Typically, blocking reagents are used to block non-specific hybridization. Such blocking reagents include, for instance, denatured salmon sperm DNA at about 100-200 μg/ml. Useful variations on these conditions will be readily apparent to those skilled in the art. Hybridization, particularly under high stringency conditions, may be suggestive of evolutionary similarity between the nucleotides. Such similarity is strongly indicative of a similar role for the nucleotides and their resultant proteins. Other parameters, such as temperature, salt concentration, and detergent concentration may be varied to achieve the desired stringency. Denaturants, such as formamide at a concentration of about 35-50% v/v, may also be used under particular circumstances, such as RNA:DNA hybridizations. Appropriate hybridization conditions are routinely determinable by one of ordinary skill in the art. "Immunologically active" or "immunogenic" describes the potential for a natural, recombinant, or synthetic peptide, epitope, polypeptide, or protein to induce antibody production in appropriate animals, cells, or cell lines. "Insertion" or "addition" refers to a change in either a nucleic or amino acid sequence in which at least one nucleotide or residue, respectively, is added to the sequence. "Labeling" refers to the covalent or noncovalent joining of a polynucleotide, polypeptide, or antibody with a reporter molecule capable of producing a detectable or measurable signal. "Microarray" is any arrangement of nucleic acids, amino acids, antibodies, etc., on a substrate. The substrate may be a solid support such as beads, glass, paper, nitrocellulose, nylon, or an appropriate membrane. "Linkers" are short stretches of nucleotide sequence which may be added to a vector or an mddt to create restriction endonuclease sites to facilitate cloning. "Polylinkers" are engineered to incorporate multiple restriction enzyme sites and to provide for the use of enzymes which leave 5' or 3' overhangs (e.g., BamHI, EcoRI, and Hindlll) and those which provide blunt ends (e.g., EcoRV, SnaBI, and Stul). "Naturally occurring" refers to an endogenous polynucleotide or polypeptide that may be isolated from viruses or prokaryotic or eukaryotic cells. "Nucleic acid sequence" refers to the specific order of nucleotides joined by phosphodiester bonds in a linear, polymeric arrangement. Depending on the number of nucleotides, the nucleic acid sequence can be considered an oligomer, oligonucleotide, or polynucleotide. The nucleic acid can be DNA, RNA, or any nucleic acid analog, such as PNA, may be of genomic or synthetic origin, may be either double-stranded or single-stranded, and can represent either the sense or antisense (complementary) strand. "Oligomer" refers to a nucleic acid sequence of at least about 6 nucleotides and as many as about 60 nucleotides, preferably about 15 to 40 nucleotides, and most preferably between about 20 and 30 nucleotides, that may be used in hybridization or amplification technologies. Oligomers may be used as, e.g., primers for PCR, and are usually chemically synthesized. "Operably linked" refers to the situation in which a first nucleic acid sequence is placed in a functional relationship with the second nucleic acid sequence. For instance, a promoter is operably linked to a coding sequence if the promoter affects the transcription or expression of the coding sequence. Generally, operably linked DNA sequences may be in close proximity or contiguous and, where necessary to join two protein coding regions, in the same reading frame. "Peptide nucleic acid" (PNA) refers to a DNA mimic in which nucleotide bases are attached to a pseudopeptide backbone to increase stability. PNAs, also designated antigene agents, can prevent gene expression by targeting complementary messenger RNA. The phrases "percent identity" and "% identity", as applied to polynucleotide sequences, refer to the percentage of residue matches between at least two polynucleotide sequences aligned using a standardized algorithm. Such an algorithm may insert, in a standardized and reproducible way, gaps in the sequences being compared in order to optimize alignment between two sequences, and therefore achieve a more meaningful comparison of the two sequences. Percent identity between polynucleotide sequences may be determined using the default parameters of the CLUSTAL V algorithm as incorporated into the MEGALIGN version 3.12e sequence alignment program. This program is part of the LASERGENE software package, a suite of molecular biological analysis programs (DNASTAR, Madison WI). CLUSTAL V is described in Higgins, D.G. and Sharp, P.M. (1989) CABIOS 5: 151 -153 and in Higgins, D.G. et al. (1992) CABIOS 8: 189-191. For pairwise alignments of polynucleotide sequences, the default parameters are set as follows: Ktuple=2, gap penalty=5, window=4, and "diagonals saved"=4. The "weighted" residue weight table is selected as the default. Percent identity is reported by CLUSTAL V as the "percent similarity" between aligned polynucleotide sequence pairs. Alternatively, a suite of commonly used and freely available sequence comparison algorithms is provided by the National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST) (Altschul, S.F. et al. (1990) J. Mol. Biol. 215:403-410), which is available from several sources, including the NCBI, Bethesda, MD, and on the Internet at http://www.ncbi.nlm.nih.gov/BLAST/. The BLAST software suite includes various sequence analysis programs including "blastn," that is used to determine alignment between a known polynucleotide sequence and other sequences on a variety of databases. Also available is a tool called "BLAST 2 Sequences" that is used for direct pairwise comparison of two nucleotide sequences. "BLAST 2 Sequences" can be accessed and used interactively at http://www.ncbi.nlm.nih.gov/gorf/bl2/. The "BLAST 2 Sequences" tool can be used for both blastn and blastp (discussed below). BLAST programs are commonly used with gap and other parameters set to default settings. For example, to compare two nucleotide sequences, one may use blastn with the "BLAST 2 Sequences" tool Version 2.0.9 (May-07-1999) set at default parameters. Such default parameters may be, for example: Matrix: BLOSUM62 Reward for match: 1 Penalty for mismatch: -2 Open Gap: 5 and Extension Gap: 2 penalties Gap x drop -off: 50 Expect: 10 Word Size: 11 Filter: on Percent identity may be measured over the length of an entire defined sequence, for example, as defined by a particular SEQ ID number, or may be measured over a shorter length, for example, over the length of a fragment taken from a larger, defined sequence, for instance, a fragment of at least 20, at least 30, at least 40, at least 50, at least 70, at least 100, or at least 200 contiguous nucleotides. Such lengths are exemplary only, and it is understood that any fragment length supported by the sequences shown herein, in figures or Sequence Listings, may be used to describe a length over which percentage identity may be measured. Nucleic acid sequences that do not show a high degree of identity may nevertheless encode similar amino acid sequences due to the degeneracy of the genetic code. It is understood that changes in nucleic acid sequence can be made using this degeneracy to produce multiple nucleic acid sequences that all encode substantially the same protein. The phrases "percent identity" and "% identity", as applied to polypeptide sequences, refer to the percentage of residue matches between at least two polypeptide sequences aligned using a standardized algorithm. Methods of polypeptide sequence alignment are well-known. Some alignment methods take into account conservative amino acid substitutions. Such conservative substitutions, explained in more detail above, generally preserve the hydrophobicity and acidity of the substituted residue, thus preserving the structure (and therefore function) of the folded polypeptide. Percent identity between polypeptide sequences may be determined using the default parameters of the CLUSTAL V algorithm as incorporated into the MEG ALIGN version 3.12e sequence alignment program (described and referenced above). For pairwise alignments of polypeptide sequences using CLUSTAL V, the default parameters are set as follows: Ktuple=l , gap penalty=3, window=5, and "diagonals saved"=5. The PAM250 matrix is selected as the default residue weight table. As with polynucleotide alignments, the percent identity is reported by CLUSTAL V as the "percent similarity" between aligned polypeptide sequence pairs. Alternatively the NCBI BLAST software suite may be used. For example, for a pairwise comparison of two polypeptide sequences, one may use the "BLAST 2 Sequences" tool Version 2.0.9 (May-07-1999) with blastp set at default parameters. Such default parameters may be, for example: Matrix: BLOSUM62 Open Gap: 11 and Extension Gap: 1 penalty Gap x drop -off: 50 Expect: 10 Word Size: 3 Filter: on Percent identity may be measured over the length of an entire defined polypeptide sequence, for example, as defined by a particular SEQ ID number, or may be measured over a shorter length, for example, over the length of a fragment taken from a larger, defined polypeptide sequence, for instance, a fragment of at least 15, at least 20, at least 30, at least 40, at least 50, at least 70 or at least 150 contiguous residues. Such lengths are exemplary only, and it is understood that any fragment length supported by the sequences shown herein, in figures or Sequence Listings, may be used to describe a length over which percentage identity may be measured. "Post-translational modification" of an MDDT may involve lipidation, glycosylation, phosphorylation, acetylation, racemization, proteolytic cleavage, and other modifications known in the art. These processes may occur synthetically or biochemically. Biochemical modifications will vary by cell type depending on the enzymatic milieu and the MDDT. "Probe" refers to mddt or fragments thereof, which are used to detect identical, allelic or related nucleic acid sequences. Probes are isolated oligonucleotides or polynucleotides attached to a detectable label or reporter molecule. Typical labels include radioactive isotopes, ligands, chemiluminescent agents, and enzymes. "Primers" are short nucleic acids, usually DNA oligonucleotides, which may be annealed to a target polynucleotide by complementary base-pairing. The primer may then be extended along the target DNA strand by a DNA polymerase enzyme. Primer pairs can be used for amplification (and identification) of a nucleic acid sequence, e.g., by the polymerase chain reaction (PCR). Probes and primers as used in the present invention typically comprise at least 15 contiguous nucleotides of a known sequence. In order to enhance specificity, longer probes and primers may also be employed, such as probes and primers that comprise at least 20, 30, 40, 50, 60, 70, 80, 90, 100, or at least 150 consecutive nucleotides of the disclosed nucleic acid sequences. Probes and primers may be considerably longer than these examples, and it is understood that any length supported by the specification, including the figures and Sequence Listing, may be used. Methods for preparing and using probes and primers are described in the references, for example Sambrook et al., 1989, Molecular Cloning: A Laboratory Manual, 2 nd ed., vol. 1-3, Cold Spring Harbor Press, Plainview NY; Ausubel et al.,1987, Current Protocols in Molecular Biology, Greene Publ. Assoc. & Wiley-Intersciences, New York NY; Innis et al., 1990, PCR Protocols. A Guide to Methods and Applications. Academic Press, San Diego CA. PCR primer pairs can be derived from a known sequence, for example, by using computer programs intended for that purpose such as Primer (Version 0.5, 1991 , Whitehead Institute for Biomedical Research, Cambridge MA). Oligonucleotides for use as primers are selected using software known in the art for such purpose. For example, OLIGO 4.06 software is useful for the selection of PCR primer pairs of up to 100 nucleotides each, and for the analysis of oligonucleotides and larger polynucleotides of up to 5,000 nucleotides from an input polynucleotide sequence of up to 32 kilobases. Similar primer selection programs have incorporated additional features for expanded capabilities. For example, the PrimOU primer selection program (available to the public from the Genome Center at University of Texas South West Medical Center, Dallas TX) is capable of choosing specific primers from megabase sequences and is thus useful for designing primers on a genome-wide scope. The Primer3 primer selection program (available to the public from the Whitehead Institute/MIT Center for Genome Research, Cambridge MA) allows the user to input a "mispriming library," in which sequences to avoid as primer binding sites are user-specified. Primer3 is useful, in particular, for the selection of oligonucleotides for microarrays. (The source code for the latter two primer selection programs may also be obtained from their respective sources and modified to meet the user's specific needs.) The PrimeGen program (available to the public from the UK Human Genome Mapping Project Resource Centre, Cambridge UK) designs primers based on multiple sequence alignments, thereby allowing selection of primers that hybridize to either the most conserved or least conserved regions of aligned nucleic acid sequences. Hence, this program is useful for identification of both unique and conserved oligonucleotides and polynucleotide fragments. The oligonucleotides and polynucleotide fragments identified by any of the above selection methods are useful in hybridization technologies, for example, as PCR or sequencing primers, microarray elements, or specific probes to identify fully or partially complementary polynucleotides in a sample of nucleic acids. Methods of oligonucleotide selection are not limited to those described above. "Purified" refers to molecules, either polynucleotides or polypeptides that are isolated or separated from their natural environment and are at least 60% free, preferably at least 75% free, and most preferably at least 90% free from other compounds with which they are naturally associated. A "recombinant nucleic acid" is a sequence that is not naturally occurring or has a sequence that is made by an artificial combination of two or more otherwise separated segments of sequence. This artificial combination is often accomplished by chemical synthesis or, more commonly, by the artificial manipulation of isolated segments of nucleic acids, e.g., by genetic engineering techniques such as those described in Sambrook, supra. The term recombinant includes nucleic acids that have been altered solely by addition, substitution, or deletion of a portion of the nucleic acid. Frequently, a recombinant nucleic acid may include a nucleic acid sequence operably linked to a promoter sequence. Such a recombinant nucleic acid may be part of a vector that is used, for example, to transform a cell. Alternatively, such recombinant nucleic acids may be part of a viral vector, e.g., based on a vaccinia virus, that could be use to vaccinate a mammal wherein the recombinant nucleic acid is expressed, inducing a protective immunological response in the mammal. "Regulatory element" refers to a nucleic acid sequence from nontranslated regions of a gene, and includes enhancers, promoters, introns, and 3' untranslated regions, which interact with host proteins to carry out or regulate transcription or translation. "Reporter" molecules are chemical or biochemical moieties used for labeling a nucleic acid, an amino acid, or an antibody. They include radionuclides; enzymes; fluorescent, chemiluminescent, or chromogenic agents; substrates; cofactors; inhibitors; magnetic particles; and other moieties known in the art. An "RNA equivalent," in reference to a DNA sequence, is composed of the same linear sequence of nucleotides as the reference DNA sequence with the exception that all occurrences of the nitrogenous base thymine are replaced with uracil, and the sugar backbone is composed of ribose instead of deoxyribose. "Sample" is used in its broadest sense. Samples may contain nucleic or amino acids, antibodies, or other materials, and may be derived from any source (e.g., bodily fluids including, but not limited to, saliva, blood, and urine; chromosome(s), organelles, or membranes isolated from a cell; genomic DNA, RNA, or cDNA in solution or bound to a substrate; and cleared cells or tissues or blots or imprints from such cells or tissues). "Specific binding" or "specifically binding" refers to the interaction between a protein or peptide and its agonist, antibody, antagonist, or other binding partner. The interaction is dependent upon the presence of a particular structure of the protein, e.g., the antigenic determinant or epitope, recognized by the binding molecule. For example, if an antibody is specific for epitope "A," the presence of a polypeptide containing epitope A, or the presence of free unlabeled A, in a reaction containing free labeled A and the antibody will reduce the amount of labeled A that binds to the antibody. "Substitution" refers to the replacement of at least one nucleotide or amino acid by a different nucleotide or amino acid. "Substrate" refers to any suitable rigid or semi-rigid support including, e.g., membranes, filters, chips, slides, wafers, fibers, magnetic or nonmagnetic beads, gels, tubing, plates, polymers, microparticles or capillaries. The substrate can have a variety of surface forms, such as wells, trenches, pins, channels and pores, to which polynucleotides or polypeptides are bound. A "transcript image" refers to the collective pattern of gene expression by a particular tissue or cell type under given conditions at a given time. "Transformation" refers to a process by which exogenous DNA enters a recipient cell. Transformation may occur under natural or artificial conditions using various methods well known in the art. Transformation may rely on any known method for the insertion of foreign nucleic acid sequences into a prokaryotic or eukaryotic host cell. The method is selected based on the host cell being transformed. "Transformants" include stably transformed cells in which the inserted DNA is capable of replication either as an autonomously replicating plasmid or as part of the host chromosome, as well as cells which transiently express inserted DNA or RNA. A "transgenic organism," as used herein, is any organism, including but not limited to animals and plants, in which one or more of the cells of the organism contains heterologous nucleic acid introduced by way of human intervention, such as by transgenic techniques well known in the art. The nucleic acid is introduced into the cell, directly or indirectly by introduction into a precursor of the cell, by way of deliberate genetic manipulation, such as by microinjection or by infection with a recombinant virus. The term genetic manipulation does not include classical cross-breeding, or in vitro fertilization, but rather is directed to the introduction of a recombinant DNA molecule. The transgenic organisms contemplated in accordance with the present invention include bacteria, cyanobacteria, fungi, and plants and animals. The isolated DNA of the present invention can be introduced into the host by methods known in the art, for example infection, transfection, transformation or transconjugation. Techniques for transferring the DNA of the present invention into such organisms are widely known and provided in references such as Sambrook et al. (1989), supra. A "variant" of a particular nucleic acid sequence is defined as a nucleic acid sequence having at least 25% sequence identity to the particular nucleic acid sequence over a certain length of one of the nucleic acid sequences using blastn with the "BLAST 2 Sequences" tool Version 2.0.9 (May-07- 1999) set at default parameters. Such a pair of nucleic acids may show, for example, at least 30%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 91 %, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% or greater sequence identity over a certain defined length. The variant may result in "conservative" amino acid changes which do not affect structural and/or chemical properties. A variant may be described as, for example, an "allelic" (as defined above), "splice," "species," or "polymorphic" variant. A splice variant may have significant identity to a reference molecule, but will generally have a greater or lesser number of polynucleotides due to alternate splicing of exons during mRNA processing. The corresponding polypeptide may possess additional functional domains or lack domains that are present in the reference molecule. Species variants are polynucleotide sequences that vary from one species to another. The resulting polypeptides generally will have significant amino acid identity relative to each other. A polymorphic variant is a variation in the polynucleotide sequence of a particular gene between individuals of a given species. Polymorphic variants also may encompass "single nucleotide polymorphisms" (SNPs) in which the polynucleotide sequence varies by one base. The presence of SNPs may be indicative of, for example, a certain population, a disease state, or a propensity for a disease state. In an alternative, variants of the polynucleotides of the present invention may be generated through recombinant methods. One possible method is a DNA shuffling technique such as MOLECULARBREEDING (Maxygen Inc., Santa Clara CA; described in U.S. Patent Number 5,837,458; Chang, C.-C. et al. (1999) Nat. Biotechnol. 17:793-797; Christians, F.C. et al. (1999) Nat. Biotechnol. 17:259-264; and Crameri, A. et al. (1996) Nat. Biotechnol. 14:315-319) to alter or improve the biological properties of MDDT, such as its biological or enzymatic activity or its ability to bind to other molecules or compounds. DNA shuffling is a process by which a library of gene variants is produced using PCR-mediated recombination of gene fragments. The library is then subjected to selection or screening procedures that identify those gene variants with the desired properties. These preferred variants may then be pooled and further subjected to recursive rounds of DNA shuffling and selection/screening. Thus, genetic diversity is created through "artificial" breeding and rapid molecular evolution. For example, fragments of a single gene containing random point mutations may be recombined, screened, and then reshuffled until the desired properties are optimized. Alternatively, fragments of a given gene may be recombined with fragments of homologous genes in the same gene family, either from the same or different species, thereby maximizing the genetic diversity of multiple naturally occurring genes in a directed and controllable manner. A "variant" of a particular polypeptide sequence is defined as a polypeptide sequence having at least 40% sequence identity to the particular polypeptide sequence over a certain length of one of the polypeptide sequences using blastp with the "BLAST 2 Sequences" tool Version 2.0.9 (May-07- 1999) set at default parameters. Such a pair of polypeptides may show, for example, at least 50%; at least 60%, at least 70%, at least 80%, at least 90%, at least 91 %, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% or greater sequence identity over a certain defined length of one of the polypeptides. THE INVENTION In a particular embodiment, cDNA sequences derived from human tissues and cell lines were aligned based on nucleotide sequence identity and assembled into "consensus" or "template" sequences which are designated by the template identification numbers (template IDs) in column 2 of Table 2. The sequence identification numbers (SEQ ID NO:s) corresponding to the template IDs are shown in column 1. The template sequences have similarity to GenBank sequences, or "hits," as designated by the GI Numbers in column 3. The statistical probability of each GenBank hit is indicated by a probability score in column 4, and the functional annotation corresponding to each GenBank hit is listed in column 5. The invention incorporates the nucleic acid sequences of these templates as disclosed in the Sequence Listing and the use of these sequences in the diagnosis and treatment of disease states characterized by defects in disease detection and treatment molecules. The invention further utilizes these sequences in hybridization and amplification technologies, and in particular, in technologies which assess gene expression patterns correlated with specific cells or tissues and their responses in vivo or in vitro to pharmaceutical agents, toxins, and other treatments. In this manner, the sequences of the present invention are used to develop a transcript image for a particular cell or tissue. Derivation of Nucleic Acid Sequences cDNA was isolated from libraries constructed using RNA derived from normal and diseased human tissues and cell lines. The human tissues and cell lines used for cDNA library construction were selected from a broad range of sources to provide a diverse population of cDNAs representative of gene transcription throughout the human body. Descriptions of the human tissues and cell lines used for cDNA library construction are provided in the LIFESEQ database (Incyte Genomics, Inc. (Incyte), Palo Alto CA). Human tissues were broadly selected from, for example, cardiovascular, dermatologic, endocrine, gastrointestinal, hematopoietic/immune system, musculoskeletal, neural, reproductive, and urologic sources. Cell lines used for cDNA library construction were derived from, for example, leukemic cells, teratocarcinomas, neuroepitheliomas, cervical carcinoma, lung fibroblasts, and endothelial cells. Such cell lines include, for example, THP-1 , urkat, HUVEC, hNT2, WI38, HeLa, and other cell lines commonly used and available from public depositories (American Type Culture Collection, Manassas VA). Prior to mRNA isolation, cell lines were untreated, treated with a pharmaceutical agent such as 5'-aza-2 -deoxycytidine, treated with an activating agent such as lipopolysaccharide in the case of leukocytic cell lines, or, in the case of endothelial cell lines, subjected to shear stress. Sequencing of the cDNAs Methods for DNA sequencing are well known in the art. Conventional enzymatic methods employ the Klenow fragment of DNA polymerase I, SEQUENASE DNA polymerase (U.S. Biochemical Corporation, Cleveland OH), Taq polymerase (Applied Biosystems, Foster City CA), thermostable T7 polymerase (Amersham Pharmacia Biotech, Inc. (Amersham Pharmacia Biotech), Piscataway NJ), or combinations of polymerases and proofreading exonucleases such as those found in the ELONGASE amplification system (Life Technologies Inc. (Life Technologies), Gaithersburg MD), to extend the nucleic acid sequence from an oligonucleotide primer annealed to the DNA template of interest. Methods have been developed for the use of both single-stranded and double- stranded templates. Chain termination reaction products may be electrophoresed on urea- polyacrylamide gels and detected either by autoradiography (for radioisotope-labeled nucleotides) or by fluorescence (for fluorophore-labeled nucleotides). Automated methods for mechanized reaction preparation, sequencing, and analysis using fluorescence detection methods have been developed. Machines used to prepare cDNAs for sequencing can include the MICROLAB 2200 liquid transfer system (Hamilton Company (Hamilton), Reno NV), Peltier thermal cycler (PTC200; MJ Research, Inc. (MJ Research), Watertown MA), and ABI CATALYST 800 thermal cycler (Applied Biosystems). Sequencing can be carried out using, for example, the ABI 373 or 377 (Applied Biosystems) or MEGABACE 1000 (Molecular Dynamics, Inc. (Molecular Dynamics), Sunnyvale CA) DNA sequencing systems, or other automated and manual sequencing systems well known in the art. The nucleotide sequences of the Sequence Listing have been prepared by current, state-of- the-art, automated methods and, as such, may contain occasional sequencing errors or unidentified nucleotides. Such unidentified nucleotides are designated by an N. These infrequent unidentified bases do not represent a hindrance to practicing the invention for those skilled in the art. Several methods employing standard recombinant techniques may be used to correct errors and complete the missing sequence information. (See, e.g., those described in Ausubel, F.M. et al. (1997) Short Protocols in Molecular Biology. John Wiley & Sons, New York NY; and Sambrook, J. et al. (1989) Molecular Cloning. A Laboratory Manual, Cold Spring Harbor Press, Plainview NY.) Assembly of cDNA Sequences Human polynucleotide sequences may be assembled using programs or algorithms well known in the art. Sequences to be assembled are related, wholly or in part, and may be derived from a single or many different transcripts. Assembly of the sequences can be performed using such programs as PHRAP (Phils Revised Assembly Program) and the GELVIEW fragment assembly system (GCG), or other methods known in the art. Alternatively, cDNA sequences are used as "component" sequences that are assembled into "template" or "consensus" sequences as follows. Sequence chromatograms are processed, verified, and quality scores are obtained using PHRED. Raw sequences are edited using an editing pathway known as Block 1 (See, e.g., the LIFESEQ Assembled User Guide, Incyte Genomics, Palo Alto, CA). A series of BLAST comparisons is performed and low-information segments and repetitive elements (e.g., dinucleotide repeats, Alu repeats, etc.) are replaced by "n's", or masked, to prevent spurious matches. Mitochondrial and ribosomal RNA sequences are also removed. The processed * sequences are then loaded into a relational database management system (RDMS) which assigns edited sequences to existing templates, if available. When additional sequences are added into the RDMS, a process is initiated which modifies existing templates or creates new templates from works in progress (i.e., nonfinal assembled sequences) containing queued sequences or the sequences themselves. After the new sequences have been assigned to templates, the templates can be merged into bins. If multiple templates exist in one bin, the bin can be split and the templates reannotated. Once gene bins have been generated based upon sequence alignments, bins are "clone joined" based upon clone information. Clone joining occurs when the 5' sequence of one clone is present in one bin and the 3' sequence from the same clone is present in a different bin, indicating that the two bins should be merged into a single bin. Only bins which share at least two different clones are merged. A resultant template sequence may contain either a partial or a full length open reading frame, or all or part of a genetic regulatory element. This variation is due in part to the fact that the full length cDNAs of many genes are several hundred, and sometimes several thousand, bases in length. With current technology, cDNAs comprising the coding regions of large genes cannot be cloned because of vector limitations, incomplete reverse transcription of the mRNA, or incomplete "second strand" synthesis. Template sequences may be extended to include additional contiguous sequences derived from the parent RNA transcript using a variety of methods known to those of skill in the art. Extension may thus be used to achieve the full length coding sequence of a gene. Analysis of the cDNA Sequences The cDNA sequences are analyzed using a variety of programs and algorithms which are well known in the art. (See, e.g., Ausubel, 1997, supra. Chapter 1.1; Meyers, R.A. (Ed.) (1995) Molecular Biology and Biotechnology. Wiley VCH, New York NY, pp. 856-853; and Table 8.) These analyses comprise both reading frame determinations, e.g., based on triplet codon periodicity for particular organisms (Fickett, J.W. (1982) Nucleic Acids Res. 10:5303-5318); analyses of potential start and stop codons; and homology searches. Computer programs known to those of skill in the art for performing computer-assisted searches for amino acid and nucleic acid sequence similarity, include, for example, Basic Local Alignment Search Tool (BLAST; Altschul, S.F. (1993) J. Mol. Evol. 36:290-300; Altschul, S.F. et al. (1990) J. Mol. Biol. 215:403-410). BLAST is especially useful in determining exact matches and comparing two sequence fragments of arbitrary but equal lengths, whose alignment is locally maximal and for which the alignment score meets or exceeds a threshold or cutoff score set by the user (Karlin, S. et al. (1988) Proc. Natl. Acad. Sci. USA 85:841-845). Using an appropriate search tool (e.g., BLAST or HMM), GenBank, SwissProt, BLOCKS, PFAM and other databases may be searched for sequences containing regions of homology to a query mddt or MDDT of the present invention. Other approaches to the identification, assembly, storage, and display of nucleotide and polypeptide sequences are provided in "Relational Database for Storing Biomolecule Information," U.S.S.N. 08/947,845, filed October 9, 1997; "Project-Based Full-Length Biomolecular Sequence Database," U.S.S.N. 08/81 1,758, filed March 6, 1997; and "Relational Database and System for Storing Information Relating to Biomolecular Sequences," U.S.S.N. 09/034,807, filed March 4, 1998, all of which are incorporated by reference herein in their entirety. Protein hierarchies can be assigned to the putative encoded polypeptide based on, e.g., motif, BLAST, or biological analysis. Methods for assigning these hierarchies are described, for example, in "Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data," U.S.S.N. 08/812,290, filed March 6, 1997, incorporated herein by reference. Human Disease Detection and Treatment Molecule Sequences The mddt of the present invention may be used for a variety of diagnostic and therapeutic purposes. For example, an mddt may be used to diagnose a particular condition, disease, or disorder associated with disease detection and treatment molecules. Such conditions, diseases, and disorders include, but are not limited to, a cell proliferative disorder, such as actinic keratosis, arteriosclerosis, atherosclerosis, bursitis, cirrhosis, hepatitis, mixed connective tissue disease (MCTD), myelofibrosis, paroxysmal nocturnal hemoglobinuria, polycythemia vera, psoriasis, primary thrombocythemia, and cancers including adenocarcinoma, leukemia, lymphoma, melanoma, myeloma, sarcoma, teratocarcinoma, and, in particular, a cancer of the adrenal gland, bladder, bone, bone marrow, brain, breast, cervix, gall bladder, ganglia, gastrointestinal tract, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, and uterus; and an autoimmune/inflammatory disorder, such as actinic keratosis, acquired immunodeficiency syndrome (AIDS), Addison's disease, adult respiratory distress syndrome, allergies, ankylosing spondylitis, amyloidosis, anemia, arteriosclerosis, asthma, atherosclerosis, autoimmune hemolytic anemia, autoimmune thyroiditis, bronchitis, bursitis, cholecystitis, cirrhosis, contact dermatitis, Crohn's disease, atopic dermatitis, dermatomyositis, diabetes mellitus, emphysema, erythroblastosis fetalis, erythema nodosum, atrophic gastritis, glomerulonephritis, Goodpasture's syndrome, gout, Graves' disease, Hashimoto's thyroiditis, paroxysmal nocturnal hemoglobinuria, hepatitis, hypereosinophilia, irritable bowel syndrome, episodic lymphopenia with lymphocytotoxins, mixed connective tissue disease (MCTD), multiple sclerosis, myasthenia gravis, myocardial or pericardial inflammation, myelofibrosis, osteoarthritis, osteoporosis, pancreatitis, polycythemia vera, polymyositis, psoriasis, Reiter's syndrome, rheumatoid arthritis, scleroderma, Sjόgren's syndrome, systemic anaphylaxis, systemic lupus erythematosus, systemic sclerosis, primary thrombocythemia, thrombocytopenic purpura, ulcerative colitis, uveitis, Werner syndrome, complications of cancer, hemodialysis, and extracorporeal circulation, trauma, and hematopoietic cancer including lymphoma, leukemia, and myeloma. The mddt can be used to detect the presence of, or to quantify the amount of, an mddt- related polynucleotide in a sample. This information is then compared to information obtained from appropriate reference samples, and a diagnosis is established. Alternatively, a polynucleotide complementary to a given mddt can inhibit or inactivate a therapeutically relevant gene related to the mddt. Analysis of mddt Expression Patterns The expression of mddt may be routinely assessed by hybridization-based methods to determine, for example, the tissue-specificity, disease-specificity, or developmental stage-specificity of mddt expression. For example, the level of expression of mddt may be compared among different cell types or tissues, among diseased and normal cell types or tissues, among cell types or tissues at different developmental stages, or among cell types or tissues undergoing various treatments. This type of analysis is useful, for example, to assess the relative levels of mddt expression in fully, or partially differentiated cells or tissues, to determine if changes in mddt expression levels are correlated with the development or progression of specific disease states, and to assess the response of a cell or tissue to a specific therapy, for example, in pharmacological or toxicological studies. Methods for the analysis of mddt expression are based on hybridization and amplification technologies and include membrane-based procedures such as northern blot analysis, high-throughput procedures that utilize, for example, microarrays, and PCR-based procedures. Hybridization and Genetic Analysis The mddt, their fragments, or complementary sequences, may be used to identify the presence of and/or to determine the degree of similarity between two (or more) nucleic acid sequences. The mddt may be hybridized to naturally occurring or recombinant nucleic acid sequences under appropriately selected temperatures and salt concentrations. Hybridization with a probe based on the nucleic acid sequence of at least one of the mddt allows for the detection of nucleic acid sequences, including genomic sequences, which are identical or related to the mddt of the Sequence Listing. Probes may be selected from non-conserved or unique regions of at least one of the polynucleotides of SEQ ID NO: 1 -252 and tested for their ability to identify or amplify the target nucleic acid sequence using standard protocols. Polynucleotide sequences that are capable of hybridizing, in particular, to those shown in SEQ ID NO: 1-252 and fragments thereof, can be identified using various conditions of stringency. (See, e.g., Wahl, G.M. and S.L. Berger (1987) Methods Enzymol. 152:399-407; Kimmel, A.R. (1987) Methods Enzymol. 152:507-51 1.) Hybridization conditions are discussed in "Definitions." A probe for use in Southern or northern hybridization may be derived from a fragment of an mddt sequence, or its complement, that is up to several hundred nucleotides in length and is either single-stranded or double-stranded. Such probes may be hybridized in solution to biological materials such as plasmids, bacterial, yeast, or human artificial chromosomes, cleared or sectioned tissues, or to artificial substrates containing mddt. Microarrays are particularly suitable for identifying the presence of and detecting the level of expression for multiple genes of interest by examining gene expression correlated with, e.g., various stages of development, treatment with a drug or compound, or disease progression. An array analogous to a dot or slot blot may be used to arrange and link polynucleotides to the surface of a substrate using one or more of the following: mechanical (vacuum), chemical, thermal, or UV bonding procedures. Such an array may contain any number of mddt and may be produced by hand or by using available devices, materials, and machines. Microarrays may be prepared, used, and analyzed using methods known in the art. (See, e.g., Brennan, T.M. et al. (1995) U.S. Patent No. 5,474,796; Schena, M. et al. (1996) Proc. Natl. Acad. Sci. USA 93: 10614-10619; Baldeschweiler et al. (1995) PCT application W095/251 1 16; Shalon, D. et al. (1995) PCT application WO95/35505; Heller, R.A. et al. (1997) Proc. Natl. Acad. Sci. USA 94:2150-2155; and Heller, MJ. et al. (1997) U.S. Patent No. 5,605,662.) Probes may be labeled by either PCR or enzymatic techniques using a variety of commercially available reporter molecules. For example, commercial kits are available for radioactive and chemiluminescent labeling (Amersham Pharmacia Biotech) and for alkaline phosphatase labeling (Life Technologies). Alternatively, mddt may be cloned into commercially available vectors for the production of RNA probes. Such probes may be transcribed in the presence of at least one labeled nucleotide (e.g., 32 P-ATP, Amersham Pharmacia Biotech). Additionally the polynucleotides of SEQ ID NO: 1-252 or suitable fragments thereof can be used to isolate full length cDNA sequences utilizing hybridization and/or amplification procedures well known in the art, e.g., cDNA library screening, PCR amplification, etc. The molecular cloning of such full length cDNA sequences may employ the method of cDNA library screening with probes using the hybridization, stringency, washing, and probing strategies described above and in Ausubel, supra. Chapters 3, 5, and 6. These procedures may also be employed with genomic libraries to isolate genomic sequences of mddt in order to analyze, e.g., regulatory elements. Genetic Mapping Gene identification and mapping are important in the investigation and treatment of almost all conditions, diseases, and disorders. Cancer, cardiovascular disease, Alzheimer's disease, arthritis, diabetes, and mental illnesses are of particular interest. Each of these conditions is more complex than the single gene defects of sickle cell anemia or cystic fibrosis, with select groups of genes being predictive of predisposition for a particular condition, disease, or disorder. For example, cardiovascular disease may result from malfunctioning receptor molecules that fail to clear cholesterol from the bloodstream, and diabetes may result when a particular individual's immune system is activated by an infection and attacks the insulin-producing cells of the pancreas. In some studies, Alzheimer's disease has been linked to a gene on chromosome 21; other studies predict a different gene and location. Mapping of disease genes is a complex and reiterative process and generally proceeds from genetic linkage analysis to physical mapping. As a condition is noted among members of a family, a genetic linkage map traces parts of chromosomes that are inherited in the same pattern as the condition. Statistics link the inheritance of particular conditions to particular regions of chromosomes, as defined by RFLP or other markers. (See, for example, Lander, E. S. and Botstein, D. (1986) Proc. Natl. Acad. Sci. USA 83:7353-7357.) Occasionally, genetic markers and their locations are known from previous studies. More often, however, the markers are simply stretches of DNA that differ among individuals. Examples of genetic linkage maps can be found in various scientific journals or at the Online Mendelian Inheritance in Man (OMIM) World Wide Web site. In another embodiment of the invention, mddt sequences may be used to generate hybridization probes useful in chromosomal mapping of naturally occurring genomic sequences. Either coding or noncoding sequences of mddt may be used, and in some instances, noncoding sequences may be preferable over coding sequences. For example, conservation of an mddt coding sequence among members of a multi-gene family may potentially cause undesired cross hybridization during chromosomal mapping. The sequences may be mapped to a particular chromosome, to a specific region of a chromosome, or to artificial chromosome constructions, e.g., human artificial chromosomes (HACs), yeast artificial chromosomes (YACs), bacterial artificial chromosomes (BACs), bacterial PI constructions, or single chromosome cDNA libraries. (See, e.g., Harrington, J.J. et al. (1997) Nat. Genet. 15:345-355; Price, CM. (1993) Blood Rev. 7:127-134; and Trask, BJ. (1991 ) Trends Genet. 7: 149- 154.) Fluorescent in situ hybridization (FISH) may be correlated with other physical chromosome mapping techniques and genetic map data. (See, e.g., Meyers, supra, pp. 965-968.) Correlation between the location of mddt on a physical chromosomal map and a specific disorder, or a predisposition to a specific disorder, may help define the region of DNA associated with that disorder. The mddt sequences may also be used to detect polymorphisms that are genetically linked to the inheritance of a particular condition, disease, or disorder. In situ hybridization of chromosomal preparations and genetic mapping techniques, such as linkage analysis using established chromosomal markers, may be used for extending existing genetic maps. Often the placement of a gene on the chromosome of another mammalian species, such as mouse, may reveal associated markers even if the number or arm of the corresponding human chromosome is not known. These new marker sequences can be mapped to human chromosomes and may provide valuable information to investigators searching for disease genes using positional cloning or other gene discovery techniques. Once a disease or syndrome has been crudely correlated by genetic linkage with a particular genomic region, e.g., ataxia-telangiectasia to 1 lq22-23, any sequences mapping to that area may represent associated or regulatory genes for further investigation. (See, e.g., Gatti, R.A. et al. (1988) Nature 336:577-580.) The nucleotide sequences of the subject invention may also be used to detect differences in chromosomal architecture due to translocation, inversion, etc., among normal, carrier, or affected individuals. Once a disease-associated gene is mapped to a chromosomal region, the gene must be cloned in order to identify mutations or other alterations (e.g., translocations or inversions) that may be correlated with disease. This process requires a physical map of the chromosomal region containing the disease-gene of interest along with associated markers. A physical map is necessary for determining the nucleotide sequence of and order of marker genes on a particular chromosomal region. Physical mapping techniques are well known in the art and require the generation of overlapping sets of cloned DNA fragments from a particular organelle, chromosome, or genome. These clones are analyzed to reconstruct and catalog their order. Once the position of a marker is determined, the DNA from that region is obtained by consulting the catalog and selecting clones from that region. The gene of interest is located through positional cloning techniques using hybridization or similar methods. Diagnostic Uses The mddt of the present invention may be used to design probes useful in diagnostic assays. Such assays, well known to those skilled in the art, may be used to detect or confirm conditions, disorders, or diseases associated with abnormal levels of mddt expression. Labeled probes developed from mddt sequences are added to a sample under hybridizing conditions of desired stringency. In some instances, mddt, or fragments or oligonucleotides derived from mddt, may be used as primers in amplification steps prior to hybridization. The amount of hybridization complex formed is quantified and compared with standards for that cell or tissue. If mddt expression varies significantly from the standard, the assay indicates the presence of the condition, disorder, or disease. Qualitative or quantitative diagnostic methods may include northern, dot blot, or other membrane or dip-stick based technologies or multiple-sample format technologies such as PCR, enzyme-linked immunosorbent assay (ELISA)-like, pin, or chip-based assays. The probes described above may also be used to monitor the progress of conditions, disorders, or diseases associated with abnormal levels of mddt expression, or to evaluate the efficacy of a particular therapeutic treatment. The candidate probe may be identified from the mddt that are specific to a given human tissue and have not been observed in GenBank or other genome databases. Such a probe may be used in animal studies, preclinical tests, clinical trials, or in monitoring the treatment of an individual patient. In a typical process, standard expression is established by methods well known in the art for use as a basis of comparison, samples from patients affected by the disorder or disease are combined with the probe to evaluate any deviation from the standard profile, and a therapeutic agent is administered and effects are monitored to generate a treatment profile. Efficacy is evaluated by determining whether the expression progresses toward or returns to the standard normal pattern. Treatment profiles may be generated over a period of several days or several months. Statistical methods well known to those skilled in the art may be use to determine the significance of such therapeutic agents. The polynucleotides are also useful for identifying individuals from minute biological samples, for example, by matching the RFLP pattern of a sample's DNA to that of an individual's DNA. The polynucleotides of the present invention can also be used to determine the actual base-by-base DNA sequence of selected portions of an individual's genome. These sequences can be used to prepare PCR primers for amplifying and isolating such selected DNA, which can then be sequenced Using this technique, an individual can be identified through a unique set of DNA sequences. Once a unique ID database is established for an individual, positive identification of that individual can be made from extremely small tissue samples In a particular aspect, oligonucleotide primers derived from the mddt of the invention may be used to detect single nucleotide polymorphisms (SNPs) SNPs are substitutions, insertions and deletions that are a frequent cause of inherited or acquired genetic disease in humans Methods of SNP detection include, but are not limited to, single-stranded conformation polymoφhism (SSCP) and fluorescent SSCP (fSSCP) methods. In SSCP, oligonucleotide primers derived from mddt are used to amplify DNA using the polymerase chain reaction (PCR) The DNA may be derived, for example, from diseased or normal tissue, biopsy samples, bodily fluids, and the like. SNPs in the DNA cause differences in the secondary and tertiary structures of PCR products in single-stranded form, and these differences are detectable using gel electrophoresis in non-denaturing gels In fSCCP, the oligonucleotide primers are fluorescently labeled', which allows detection of the amplimers in high- throughput equipment such as DNA sequencing machines Additionally, sequence database analysis methods, termed in silico SNP (isSNP), are capable of identifying polymoφhisms by comparing the sequences of individual overlapping DNA fragments which assemble into a common consensus sequence These computer-based methods filter out sequence variations due to laboratory preparation of DNA and sequencing errors using statistical models and automated analyses of DNA sequence chromatograms In the alternative, SNPs may be detected and characterized by mass spectrometry using, for example, the high throughput MASSARRAY system (Sequenom, Inc , San Diego CA) DNA-based identification techniques are critical in forensic technology. DNA sequences taken from very small biological samples such as tissues, e.g , hair or skin, or body fluids, e.g., blood, saliva, semen, etc , can be amplified using, e.g., PCR, to identify individuals. (See, e.g , Erhch, H. (1992) PCR Technology, Freeman and Co , New York, NY) Similarly, polynucleotides of the present invention can be used as polymoφhic markers. There is also a need for reagents capable of identifying the source of a particular tissue. Appropriate reagents can comprise, for example, DNA probes or primers prepared from the sequences of the present invention that are specific for particular tissues Panels of such reagents can identify tissue by species and/or by organ type. In a similar fashion, these reagents can be used to screen tissue cultures for contamination. The polynucleotides of the present invention can also be used as molecular weight markers on nucleic acid gels or Southern blots, as diagnostic probes for the presence of a specific mRNA in a particular cell type, in the creation of subtracted cDNA libraries which aid in the discovery of novel polynucleotides, in selection and synthesis of oligomers for attachment to an array or other support, and as an antigen to elicit an immune response. Disease Model Systems Using mddt The mddt of the invention or their mammalian homologs may be "knocked out" in an animal model system using homologous recombination in embryonic stem (ES) cells. Such techniques are well known in the art and are useful for the generation of animal models of human disease. (See, e.g., U.S. Patent Number 5,175,383 and U.S. Patent Number 5,767,337.) For example, mouse ES cells, such as the mouse 129/SvJ cell line, are derived from the early mouse embryo and grown in culture. The ES cells are transformed with a vector containing the gene of interest disrupted by a marker gene, e.g., the neomycin phosphotransferase gene (neo; Capecchi, M.R. (1989) Science 244:1288-1292). The vector integrates into the corresponding region of the host genome by homologous recombination. Alternatively, homologous recombination takes place using the Cre-loxP system to knockout a gene of interest in a tissue- or developmental stage-specific manner (Marth, J.D. (1996) Clin. Invest. 97: 1999- 2002; Wagner, K.U. et al. (1997) Nucleic Acids Res. 25:4323-4330). Transformed ES cells are identified and microinjected into mouse cell blastocysts such as those from the C57BL/6 mouse strain. The blastocysts are surgically transferred to pseudopregnant dams, and the resulting chimeric progeny are genotyped and bred to produce heterozygous or homozygous strains. Transgenic animals thus generated may be tested with potential therapeutic or toxic agents. The mddt of the invention may also be manipulated in vitro in ES cells derived from human blastocysts. Human ES cells have the potential to differentiate into at least eight separate cell lineages including endoderm, mesoderm, and ectodermal cell types. These cell lineages differentiate into, for example, neural cells, hematopoietic lineages, and cardiomyocytes (Thomson, J.A. et al. (1998) Science 282: 1 145-1 147). The mddt of the invention can also be used to create "knockin" humanized animals (pigs) or transgenic animals (mice or rats) to model human disease. With knockin technology, a region of mddt is injected into animal ES cells, and the injected sequence integrates into the animal cell genome. Transformed cells are injected into blastulae, and the blastulae are implanted as described above. Transgenic progeny or inbred lines are studied and treated with potential pharmaceutical agents to obtain information on treatment of a human disease. Alternatively, a mammal inbred to overexpress mddt, resulting, e.g., in the secretion of MDDT in its milk, may also serve as a convenient source of that protein (Janne, J. et al. (1998) Biotechnol. Annu. Rev. 4:55-74). Screening Assays MDDT encoded by polynucleotides of the present invention may be used to screen for molecules that bind to or are bound by the encoded polypeptides. The binding of the polypeptide and the molecule may activate (agonist), increase, inhibit (antagonist), or decrease activity of the polypeptide or the bound molecule. Examples of such molecules include antibodies, oligonucleotides, proteins (e.g., receptors), or small molecules. Preferably, the molecule is closely related to the natural ligand of the polypeptide, e.g., a ligand or fragment thereof, a natural substrate, or a structural or functional mimetic. (See, Coligan et al., (1991 ) Current Protocols in Immunology 1 (2): Chapter 5.) Similarly, the molecule can be closely related to the natural receptor to which the polypeptide binds, or to at least a fragment of the receptor, e.g., the active site. In either case, the molecule can be rationally designed using known techniques. Preferably, the screening for these molecules involves producing appropriate cells which express the polypeptide, either as a secreted protein or on the cell membrane. Preferred cells include cells from mammals, yeast, Drosophila, or E. coli. Cells expressing the polypeptide or cell membrane fractions which contain the expressed polypeptide are then contacted with a test compound and binding, stimulation, or inhibition of activity of either the polypeptide or the molecule is analyzed. An assay may simply test binding of a candidate compound to the polypeptide, wherein binding is detected by a fluorophore, radioisotope, enzyme conjugate, or other detectable label. Alternatively, the assay may assess binding in the presence of a labeled competitor. Additionally, the assay can be carried out using cell-free preparations, polypeptide/molecule affixed to a solid support, chemical libraries, or natural product mixtures. The assay may also simply comprise the steps of mixing a candidate compound with a solution containing a polypeptide, measuring polypeptide/molecule activity or binding, and comparing the polypeptide/molecule activity or binding to a standard. Preferably, an ELISA assay using, e.g., a monoclonal or polyclonal antibody, can measure polypeptide level in a sample. The antibody can measure polypeptide level by either binding, directly or indirectly, to the polypeptide or by competing with the polypeptide for a substrate. All of the above assays can be used in a diagnostic or prognostic context. The molecules discovered using these assays can be used to treat disease or to bring about a particular result in a patient (e.g., blood vessel growth) by activating or inhibiting the polypeptide/molecule. Moreover, the assays can discover agents which may inhibit or enhance the production of the polypeptide from suitably manipulated cells or tissues. Transcript Imaging and Toxicological Testing Another embodiment relates to the use of mddt to develop a transcript image of a tissue or cell type. A transcript image represents the global pattern of gene expression by a particular tissue or cell type. Global gene expression patterns are analyzed by quantifying the number of expressed genes and their relative abundance under given conditions and at a given time. (See Seilhamer et al., "Comparative Gene Transcript Analysis," U.S. Patent Number 5,840,484, expressly incoφorated by reference herein.) Thus a transcript image may be generated by hybridizing the polynucleotides of the present invention or their complements to the totality of transcripts or reverse transcripts of a particular tissue or cell type. In one embodiment, the hybridization takes place in high-throughput format, wherein the polynucleotides of the present invention or their complements comprise a subset of a plurality of elements on a microarray. The resultant transcript image would provide a profile of gene activity pertaining to disease detection and treatment molecules. Transcript images which profile mddt expression may be generated using transcripts isolated from tissues, cell lines, biopsies, or other biological samples. The transcript image may thus reflect mddt expression in vivo, as in the case of a tissue or biopsy sample, or in vitro, as in the case of a cell line. Transcript images which profile mddt expression may also be used in conjunction with in vitro model systems and preclinical evaluation of pharmaceuticals, as well as toxicological testing of industrial and naturally-occurring environmental compounds. All compounds induce characteristic gene expression patterns, frequently termed molecular fingeφrints or toxicant signatures, which are indicative of mechanisms of action and toxicity (Nuwaysir, E. F. et al. (1999) Mol. Carcinog. 24' 153- 159; Steiner, S. and Anderson, N. L. (2000) Toxicol. Lett. 112-1 13:467-71 , expressly incoφorated by reference herein). If a test compound has a signature similar to that of a compound with known toxicity, it is likely to share those toxic properties. These fingeφrints or signatures are most useful and refined when they contain expression information from a large number of genes and gene families. Ideally, a genome-wide measurement of expression provides the highest quality signature. Even genes whose expression is not altered by any tested compounds are important as well, as the levels of expression of these genes are used to normalize the rest of the expression data. The normalization procedure is useful for comparison of expression data after treatment with different compounds. While the assignment of gene function to elements of a toxicant signature aids in inteφretation of toxicity mechanisms, knowledge of gene function is not necessary for the statistical matching of signatures which leads to prediction of toxicity. (See, for example, Press Release 00-02 from the National Institute of Environmental Health Sciences, released February 29, 2000, available at http://www.niehs.nih.gov/oc/news/toxchip.htm.) Therefore, it is important and desirable in toxicological screening using toxicant signatures to include all expressed gene sequences. In one embodiment, the toxicity of a test compound is assessed by treating a biological sample containing nucleic acids with the test compound. Nucleic acids that are expressed in the treated biological sample are hybridized with one or more probes specific to the polynucleotides of the present invention, so that transcript levels corresponding to the polynucleotides of the present invention may be quantified. The transcript levels in the treated biological sample are compared with levels in an untreated biological sample. Differences in the transcript levels between the two samples are indicative of a toxic response caused by the test compound in the treated sample. Another particular embodiment relates to the use of MDDT encoded by polynucleotides of the present invention to analyze the proteome of a tissue or cell type. The term proteome refers to the global pattern of protein expression in a particular tissue or cell type. Each protein component of a proteome can be subjected individually to further analysis. Proteome expression patterns, or profiles, are analyzed by quantifying the number of expressed proteins and their relative abundance under given conditions and at a given time. A profile of a cell's proteome may thus be generated by separating and analyzing the polypeptides of a particular tissue or cell type. In one embodiment, the separation is achieved using two-dimensional gel electrophoresis, in which proteins from a sample are separated by isoelectric focusing in the first dimension, and then according to molecular weight by sodium dodecyl sulfate slab gel electrophoresis in the second dimension (Steiner and Anderson, supra). The proteins are visualized in the gel as discrete and uniquely positioned spots, typically by staining the gel with an agent such as Coomassie Blue or silver or fluorescent stains. The optical density of each protein spot is generally proportional to the level of the protein in the sample. The optical densities of equivalently positioned protein spots from different samples, for example, from biological samples either treated or untreated with a test compound or therapeutic agent, are compared to identify any changes in protein spot density related to the treatment. The proteins in the spots are partially sequenced using, for example, standard methods employing chemical or enzymatic cleavage followed by mass spectrometry. The identity of the protein in a spot may be determined by comparing its partial sequence, preferably of at least 5 contiguous amino acid residues, to the polypeptide sequences of the present invention. In some cases, further sequence data may be obtained for definitive protein identification. A proteomic profile may also be generated using antibodies specific for MDDT to quantify the levels of MDDT expression. In one embodiment, the antibodies are used as elements on a microarray, and protein expression levels are quantified by exposing the microarray to the sample and detecting the levels of protein bound to each array element (Lueking, A. et al. (1999) Anal. Biochem. 270:103-1 1 ; Mendoze, L. G. et al. (1999) Biotechniques 27:778-88). Detection may be performed by a variety of methods known in the art, for example, by reacting the proteins in the sample with a thiol- or ami no-reactive fluorescent compound and detecting the amount of fluorescence bound at each array element. Toxicant signatures at the proteome level are also useful for toxicological screening, and should be analyzed in parallel with toxicant signatures at the transcript level. There is a poor correlation between transcript and protein abundances for some proteins in some tissues (Anderson, N. L. and Seilhamer, J. (1997) Electrophoresis 18:533-537), so proteome toxicant signatures may be useful in the analysis of compounds which do not significantly affect the transcript image, but which alter the proteomic profile. In addition, the analysis of transcripts in body fluids is difficult, due to rapid degradation of mRNA, so proteomic profiling may be more reliable and informative in such cases. In another embodiment, the toxicity of a test compound is assessed by treating a biological sample containing proteins with the test compound. Proteins that are expressed in the treated biological sample are separated so that the amount of each protein can be quantified. The amount of each protein is compared to the amount of the corresponding protein in an untreated biological sample. A difference in the amount of protein between the two samples is indicative of a toxic response to the test compound in the treated sample. Individual proteins are identified by sequencing the amino acid residues of the individual proteins and comparing these partial sequences to the MDDT encoded by polynucleotides of the present invention. In another embodiment, the toxicity of a test compound is assessed by treating a biological sample containing proteins with the test compound. Proteins from the biological sample are incubated with antibodies specific to the MDDT encoded by polynucleotides of the present invention. The amount of protein recognized by the antibodies is quantified. The amount of protein in the treated biological sample is compared with the amount in an untreated biological sample. A difference in the amount of protein between the two samples is indicative of a toxic response to the test compound in the treated sample. Transcript images may be used to profile mddt expression in distinct tissue types. This process can be used to determine disease detection and treatment molecule activity in a particular tissue type relative to this activity in a different tissue type. Transcript images may be used to generate a profile of mddt expression characteristic of diseased tissue. Transcript images of tissues before and after treatment may be used for diagnostic puφoses, to monitor the progression of disease, and to monitor the efficacy of drug treatments for diseases which affect the activity of disease detection and treatment molecules. Transcript images of cell lines can be used to assess disease detection and treatment molecule activity and/or to identify cell lines that lack or misregulate this activity. Such cell lines may then be treated with pharmaceutical agents, and a transcript image following treatment may indicate the efficacy of these agents in restoring desired levels of this activity. A similar approach may be used to assess the toxicity of pharmaceutical agents as reflected by undesirable changes in disease detection and treatment molecule activity. Candidate pharmaceutical agents may be evaluated by comparing their associated transcript images with those of pharmaceutical agents of known effectiveness. Antisense Molecules The polynucleotides of the present invention are useful in antisense technology. Antisense technology or therapy relies on the modulation of expression of a target protein through the specific binding of an antisense sequence to a target sequence encoding the target protein or directing its expression. (See, e.g., Agrawal, S., ed. (1996) Antisense Therapeutics, Humana Press Inc., Totawa NJ; Alama, A. et al. (1997) Pharmacol. Res. 36(3): 171-178; Crooke, S.T. (1997) Adv. Pharmacol. 40: 1-49; Sharma, H.W. and R. Narayanan (1995) Bioessays 17(12):1055-1063; and Lavrosky, Y. et al. (1997) Biochem. Mol. Med. 62(1): 1 1-22.) An antisense sequence is a polynucleotide sequence capable of specifically hybridizing to at least a portion of the target sequence. Antisense sequences bind to cellular mRNA and/or genomic DNA, affecting translation and or transcription. Antisense sequences can be DNA, RNA, or nucleic acid mimics and analogs. (See, e.g., Rossi, J.J. et al. (1991) Antisense Res. Dev. l(3):285-288; Lee, R. et al. (1998) Biochemistry 37(3):900-1010; Pardridge, W.M. et al. (1995) Proc. Natl. Acad. Sci. USA 92(12):5592-5596; and Nielsen, P. E. and Haaima, G. (1997) Chem. Soc. Rev. 96:73-78.) Typically, the binding which results in modulation of expression occurs through hybridization or binding of complementary base pairs. Antisense sequences can also bind to DNA duplexes through specific interactions in the major groove of the double helix. The polynucleotides of the present invention and fragments thereof can be used as antisense sequences to modify the expression of the polypeptide encoded by mddt. The antisense sequences can be produced ex vivo, such as by using any of the ABI nucleic acid synthesizer series (Applied Biosystems) or other automated systems known in the art. Antisense sequences can also be produced biologically, such as by transforming an appropriate host cell with an expression vector containing the sequence of interest. (See, e.g., Agrawal, supra.) In therapeutic use, any gene delivery system suitable for introduction of the antisense sequences into appropriate target cells can be used. Antisense sequences can be delivered intracellularly in the form of an expression plasmid which, upon transcription, produces a sequence complementary to at least a portion of the cellular sequence encoding the target protein. (See, e.g., Slater, J.E., et al. (1998) J. Allergy Clin. Immunol. 102(3):469-475; and Scanlon, K.J., et al. (1995) 9(13): 1288- 1296.) Antisense sequences can also be introduced intracellularly through the use of viral vectors, such as retrovirus and adeno-associated virus vectors. (See, e.g., Miller, A.D. (1990) Blood 76:271 ; Ausubel, F.M. et al. (1995) Current Protocols in Molecular Biology. John Wiley & Sons, New York NY; Uckert, W. and W. Walther (1994) Pharmacol. Ther. 63(3):323-347.) Other gene delivery mechanisms include liposome-derived systems, artificial viral envelopes, and other systems known in the art. (See, e.g., Rossi, J.J. (1995) Br. Med. Bull. 51(l):217-225; Boado, RJ. et al. (1998) J. Pharm. Sci. 87(1 1 ): 1308-1315; and Morris, M.C. et al. (1997) Nucleic Acids Res. 25(14):2730-2736.) Expression In order to express a biologically active MDDT, the nucleotide sequences encoding MDDT or fragments thereof may be inserted into an appropriate expression vector, i.e., a vector which contains the necessary elements for transcriptional and translational control of the inserted coding sequence in a suitable host. Methods which are well known to those skilled in the art may be used to construct expression vectors containing sequences encoding MDDT and appropriate transcriptional and translational control elements. These methods include in vitro recombinant DNA techniques, synthetic techniques, and in vivo genetic recombination. (See, e.g., Sambrook, supra. Chapters 4, 8, 16, and 17; and Ausubel, supra. Chapters 9, 10, 13, and 16.) A variety of expression vector/host systems may be utilized to contain and express sequences encoding MDDT. These include, but are not limited to, microorganisms such as bacteria transformed with recombinant bacteriophage, plasmid, or cosmid DNA expression vectors; yeast transformed with yeast expression vectors; insect cell systems infected with viral expression vectors (e.g., baculovirus); plant cell systems transformed with viral expression vectors (e.g., cauliflower mosaic virus, CaMV, or tobacco mosaic virus, TMV) or with bacterial expression vectors (e.g., Ti or pBR322 plasmids); or animal (mammalian) cell systems. (See, e.g., Sambrook, supra; Ausubel, 1995, supra. Van Heeke, G. and S.M. Schuster (1989) J. Biol. Chem. 264:5503-5509; Bitter, G.A. et al. (1987) Methods Enzymol. 153:516-544; Scorer, C.A. et al. (1994) Bio/Technology 12: 181 -184; Engelhard, E.K. et al. (1994) Proc. Natl. Acad. Sci. USA 91 :3224-3227; Sandig, V. et al. (1996) Hum. Gene Ther. 7:1937-1945; Takamatsu, N. (1987) EMBO J. 6:307-31 1 ; Coruzzi, G. et al. (1984) EMBO J. 3: 1671-1680; Brogue, R. et al. (1984) Science 224:838-843; Winter, J. et al. (1991) Results Probl. Cell Differ. 17:85-105; The McGraw Hill Yearbook of Science and Technology (1992) McGraw Hill, New York NY, pp. 191-196; Logan, J. and T. Shenk (1984) Proc. Natl. Acad. Sci. USA 81 :3655-3659; and Harrington, J.J. et al. (1997) Nat. Genet. 15:345-355.) Expression vectors derived from retroviruses, adenoviruses, or heφes or vaccinia viruses, or from various bacterial plasmids, may be used for delivery of nucleotide sequences to the targeted organ, tissue, or cell population. (See, e.g., Di Nicola, M; et al. (1998) Cancer Gen. Ther. 5(6):350-356; Yu, M. et al., (1993) Proc. Natl. Acad. Sci. USA 90(13):6340-6344; Buller, R.M. et al. (1985) Nature 317(6040):813-815; McGregor, D.P. et al. (1994) Mol. Immunol. 31(3):219-226; and Verma, I.M. and N. Somia (1997) Nature 389:239-242.) The invention is not limited by the host cell employed. For long term production of recombinant proteins in mammalian systems, stable expression of MDDT in cell lines is preferred. For example, sequences encoding MDDT can be transformed into cell lines using expression vectors which may contain viral origins of replication and/or endogenous expression elements and a selectable marker gene on the same or on a separate vector. Any number of selection systems may be used to recover transformed cell lines. (See, e.g., Wigler, M. et al. (1977) Cell 1 1 :223-232; Lowy, I. et al. (1980) Cell 22:817-823.; Wigler, M. et al. (1980) Proc. Natl. Acad. Sci. USA 77:3567-3570; Colbere-Garapin, F. et al. (1981) J. Mol. Biol. 150:1-14; Hartman, S.C. and R.C.Mulligan (1988) Proc. Natl. Acad. Sci. USA 85:8047-8051 ; Rhodes, C.A. (1995) Methods Mol. Biol. 55: 121-131.) Therapeutic Uses of mddt The mddt of the invention may be used for somatic or germline gene therapy. Gene therapy may be performed to (i) correct a genetic deficiency (e.g., in the cases of severe combined immunodeficiency (SCID)-Xl disease characterized by X-linked inheritance (Cavazzana-Calvo, M. et al. (2000) Science 288:669-672), severe combined immunodeficiency syndrome associated with an inherited adenosine deaminase (ADA) deficiency (Blaese, R.M. et al. (1995) Science 270:475-480; Bordignon, C. et al. (1995) Science 270:470-475), cystic fibrosis (Zabner, J. et al. (1993) Cell 75:207- 216; Crystal, R.G. et al. (1995) Hum. Gene Therapy 6:643-666; Crystal, R.G. et al. (1995) Hum. Gene Therapy 6:667-703), thalassemias, familial hypercholesterolemia, and hemophilia resulting from Factor VIII or Factor IX deficiencies (Crystal, R.G. (1995) Science 270:404-410; Verma, I.M. and Somia, N. (1997) Nature 389:239-242)), (ii) express a conditionally lethal gene product (e.g., in the case of cancers which result from unregulated cell proliferation), or (iii) express a protein which affords protection against intracellular parasites (e.g., against human retroviruses, such as human immunodeficiency virus (HIV) (Baltimore, D. (1988) Nature 335:395-396; Poeschla, E. et al. (1996) Proc. Natl. Acad. Sci. USA. 93: 1 1395-11399), hepatitis B or C virus (HBV, HCV); fungal parasites, such as Candida albicans and Paracoccidioides brasiliensis; and protozoan parasites such as Plasmodium falciparum and Trvpanosoma cruzi). In the case where a genetic deficiency in mddt expression or regulation causes disease, the expression of mddt from an appropriate population of transduced cells may alleviate the clinical manifestations caused by the genetic deficiency. In a further embodiment of the invention, diseases or disorders caused by deficiencies in mddt are treated by constructing mammalian expression vectors comprising mddt and introducing these vectors by mechanical means into mddt-deficient cells. Mechanical transfer technologies for use with cells in vivo or ex vitro include (i) direct DNA microinjection into individual cells, (ii) ballistic gold particle delivery, (iii) liposome-mediated transfection, (iv) receptor-mediated gene transfer, and (v) the use of DNA transposons (Morgan, R.A. and Anderson, W.F. (1993) Annu. Rev. Biochem. 62: 191- 217; Ivies, Z. (1997) Cell 91 :501-510; Boulay, J-L. and Recipon, H. (1998) Curr. Opin. Biotechnol. 9:445-450). Expression vectors that may be effective for the expression of mddt include, but are not limited to, the PCDNA 3.1 , EPITAG, PRCCMV2, PREP, PVAX vectors (Invitrogen, Carlsbad CA), PCMV-SCRIPT, PCMV-TAG, PEGSH/PERV (Stratagene, La Jolla CA), and PTET-OFF, PTET-ON, PTRE2, PTRE2-LUC, PTK-HYG (Clontech, Palo Alto CA). The mddt of the invention ' may be expressed using (i) a constitutively active promoter, (e.g., from cytomegalovirus (CMV), Rous sarcoma virus (RSV), SV40 virus, thymidine kinase (TK), or β-actin genes), (ii) an inducible promoter (e.g., the tetracycline-regulated promoter (Gossen, M. and Bujard, H. (1992) Proc. Natl. Acad. Sci. U.S.A. 89:5547-5551 ; Gossen, M. et al., (1995) Science 268: 1766-1769; Rossi, F.M.V. and Blau, H.M. (1998) Curr. Opin. Biotechnol. 9:451-456), commercially available in the T-REX plasmid (Invitrogen); the ecdysone-inducible promoter (available in the plasmids PVGRXR and PIND; Invitrogen); the FK506/rapamycin inducible promoter; or the RU486/mifepristone inducible promoter (Rossi, F.M.V. and Blau, H.M. supra), or (iii) a tissue-specific promoter or the native promoter of the endogenous gene encoding MDDT from a normal individual. Commercially available liposome transformation kits (e.g., the PERFECT LIPID TRANSFECTION KIT, available from Invitrogen) allow one with ordinary skill in the art to deliver polynucleotides to target cells in culture and require minimal effort to optimize experimental parameters. In the alternative, transformation is performed using the calcium phosphate method (Graham, F.L. and Eb, A.J. (1973) Virology 52:456-467), or by electroporation (Neumann, E. et al. (1982) EMBO J. 1 :841-845). The introduction of DNA to primary cells requires modification of these standardized mammalian transfection protocols. In another embodiment of the invention, diseases or disorders caused by genetic defects with respect to mddt expression are treated by constructing a retrovirus vector consisting of (i) mddt under the control of an independent promoter or the retrovirus long terminal repeat (LTR) promoter, (ii) appropriate RNA packaging signals, and (iii) a Rev-responsive element (RRE) along with additional retrovirus cw-acting RNA sequences and coding sequences required for efficient vector propagation. Retrovirus vectors (e.g., PFB and PFBNEO) are commercially available (Stratagene) and are based on published data (Riviere, I. et al. (1995) Proc. Natl. Acad. Sci. U.S.A. 92:6733-6737), incoφorated by reference herein. The vector is propagated in an appropriate vector producing cell line (VPCL) that expresses an envelope gene with a tropism for receptors on the target cells or a promiscuous envelope protein such as VSVg (Armentano, D. et al. (1987) J. Virol. 61:1647-1650; Bender, M.A. et al. (1987) J. Virol. 61 : 1639-1646; Adam, M.A. and Miller, A.D. (1988) J. Virol. 62:3802-3806; Dull, T. et al. (1998) J. Virol. 72:8463-8471 ; Zufferey, R. et al. (1998) J. Virol. 72:9873-9880). U.S. Patent Number 5,910,434 to Rigg ("Method for obtaining retrovirus packaging cell lines producing high transducing efficiency retroviral supernatant") discloses a method for obtaining retrovirus packaging cell lines and is hereby incoφorated by reference. Propagation of retrovirus vectors, transduction of a population of cells (e.g., CD4 + T-cells), and the return of transduced cells to a patient are procedures well known to persons skilled in the art of gene therapy and have been well documented (Ranga, U. et al. (1997) J. Virol. 71 :7020-7029; Bauer, G. et al. (1997) Blood 89:2259-2267; Bonyhadi, M.L. (1997) J. Virol. 71 :4707-4716; Ranga, U. et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95: 1201- 1206; Su, L. ( 1997) Blood 89:2283-2290). In the alternative, an adenovirus-based gene therapy delivery system is used to deliver mddt to cells which have one or more genetic abnormalities with respect to the expression of mddt. The construction and packaging of adenovirus-based vectors are well known to those with ordinary skill in the art. Replication defective adenovirus vectors have proven to be versatile for importing genes encoding immunoregulatory proteins into intact islets in the pancreas (Csete, M.E. et al. (1995) Transplantation 27:263-268). Potentially useful adenoviral vectors are described in U.S. Patent Number 5,707,618 to Armentano ("Adenovirus vectors for gene therapy"), hereby incoφorated by reference. For adenoviral vectors, see also Antinozzi, P.A. et al. (1999) Annu. Rev. Nutr. 19:51 1-544 and Verma, I.M. and Somia, N. (1997) Nature 18:389:239-242, both incorporated by reference herein. In another alternative, a heφes-based, gene therapy delivery system is used to deliver mddt to target cells which have one or more genetic abnormalities with respect to the expression of mddt. The use of herpes simplex virus (HSV)-based vectors may be especially valuable for introducing mddt to cells of the central nervous system, for which HSV has a tropism. The construction and packaging of heφes-based vectors are well known to those with ordinary skill in the art. A replication-competent herpes simplex virus (HSV) type 1-based vector has been used to deliver a reporter gene to the eyes of primates (Liu, X. et al. (1999) Exp. Eye Res. 169:385-395). The construction of a HSV- 1 virus vector has also been disclosed in detail in U.S. Patent Number 5,804,413 to DeLuca ("Heφes simplex virus strains for gene transfer"), which is hereby incoφorated by reference. U.S. Patent Number 5,804,413 teaches the use of recombinant HSV d92 which consists of a genome containing at least one exogenous gene to be transferred to a cell under the control of the appropriate promoter for puφoses including human gene therapy. Also taught by this patent are the construction and use of recombinant HSV strains deleted for ICP4, ICP27 and ICP22. For HSV vectors, see also Goins, W. F. et al. 1999 J. Virol. 73:519-532 and Xu, H. et al., (1994) Dev. Biol. 163: 152-161 , hereby incoφorated by reference. The manipulation of cloned heφesvirus sequences, the generation of recombinant virus following the transfection of multiple plasmids containing different segments of the large heφesvirus genomes, the growth and propagation of heφesvirus, and the infection of cells with herpesvirus are techniques well known to those of ordinary skill in the art. In another alternative, an alphavirus (positive, single-stranded RNA virus) vector is used to deliver mddt to target cells. The biology of the prototypic alphavirus, Semliki Forest Virus (SFV), has been studied extensively and gene transfer vectors have been based on the SFV genome (Garoff, H. and Li, K-J. (1998) Curr. Opin. Biotech. 9:464-469). During alphavirus RNA replication, a subgenomic RNA is generated that normally encodes the viral capsid proteins. This subgenomic RNA replicates to higher levels than the full-length genomic RNA, resulting in the oveφroduction of capsid proteins relative to the viral proteins with enzymatic activity (e.g., protease and polymerase). Similarly, inserting mddt into the alphavirus genome in place of the capsid-coding region results in the production of a large number of mddt RNAs and the synthesis of high levels of MDDT in vector transduced cells. While alphavirus infection is typically associated with cell lysis within a few days, the ability to establish a persistent infection in hamster normal kidney cells (BHK-21) with a variant of Sindbis virus (SIN) indicates that the lytic replication of alphaviruses can be altered to suit the needs of the gene therapy application (Dryga, S.A. et al. ( 1997) Virology 228:74-83). The wide host range of alphaviruses will allow the introduction of mddt into a variety of cell types. The specific transduction of a subset of cells in a population may require the sorting of cells prior to transduction. The methods of manipulating infectious cDNA clones of alphaviruses, performing alphavirus cDNA and RNA transfections, and performing alphavirus infections, are well known to those with ordinary skill in the art. Antibodies Anti-MDDT antibodies may be used to analyze protein expression levels. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, and Fab fragments. For descriptions of and protocols of antibody technologies, see, e.g., Pound J.D. (1998) Immunochemical Protocols. Humana Press, Totowa, NJ. The amino acid sequence encoded by the mddt of the Sequence Listing may be analyzed by appropriate software (e.g., LASERGENE NAVIGATOR software, DNASTAR) to determine regions of high immunogenicity. The optimal sequences for immunization are selected from the C- terminus, the N-terminus, and those intervening, hydrophilic regions of the polypeptide which are likely to be exposed to the external environment when the polypeptide is in its natural conformation. Analysis used to select appropriate epitopes is also described by Ausubel (1997, supra. Chapter 1 1.7). Peptides used for antibody induction do not need to have biological activity; however, they must be antigenic. Peptides used to induce specific antibodies may have an amino acid sequence consisting of at least five amino acids, preferably at least 10 amino acids, and most preferably at least 15 amino acids. A peptide which mimics an antigenic fragment of the natural polypeptide may be fused with another protein such as keyhole hemolimpet cyanin (KLH; Sigma, St. Louis MO) for antibody production. A peptide encompassing an antigenic region may be expressed from an mddt, synthesized as described above, or purified from human cells. Procedures well known in the art may be used for the production of antibodies. Various hosts including mice, goats, and rabbits, may be immunized by injection with a peptide. Depending on the host species, various adjuvants may be used to increase immunological response. In one procedure, peptides about 15 residues in length may be synthesized using an ABI 431 A peptide synthesizer (Applied Biosystems) using fmoc-chemistry and coupled to KLH (Sigma) by reaction with M-maleimidobenzoyl-N-hydroxysuccinimide ester (Ausubel, 1995, supra). Rabbits are immunized with the peptide-KLH complex in complete Freund's adjuvant. The resulting antisera are tested for antipeptide activity by binding the peptide to plastic, blocking with 1 % bovine serum albumin (BSA), reacting with rabbit antisera, washing, and reacting with radioiodinated goat anti-rabbit IgG. Antisera with antipeptide activity are tested for anti-MDDT activity using protocols well known in the art, including ELISA, radioimmunoassay (RIA), and immunoblotting. In another procedure, isolated and purified peptide may be used to immunize mice (about 100 μg of peptide) or rabbits (about 1 mg of peptide). Subsequently, the peptide is radioiodinated and used to screen the immunized animals' B-lymphocytes for production of antipeptide antibodies. Positive cells are then used to produce hybridomas using standard techniques. About 20 mg of peptide is sufficient for labeling and screening several thousand clones. Hybridomas of interest are detected by screening with radioiodinated peptide to identify those fusions producing peptide-specific monoclonal antibody. In a typical protocol, wells of a multi-well plate (FAST, Becton-Dickinson, Palo Alto, CA) are coated with affinity-purified, specific rabbit-anti-mouse (or suitable anti-species IgG) antibodies at 10 mg ml. The coated wells are blocked with 1 % BSA and washed and exposed to supernatants from hybridomas. After incubation, the wells are exposed to radiolabeled peptide at 1 mg/ml. Clones producing antibodies bind a quantity of labeled peptide that is detectable above background. Such clones are expanded and subjected to 2 cycles of cloning. Cloned hybridomas are injected into pristane-treated mice to produce ascites, and monoclonal antibody is purified from the ascitic fluid by affinity chromatography on protein A (Amersham Pharmacia Biotech). Several procedures for the production of monoclonal antibodies, including in vitro production, are described in Pound (supra). Monoclonal antibodies with antipeptide activity are tested for anti-MDDT activity using protocols well known in the art, including ELISA, RIA, and immunoblotting. Antibody fragments containing specific binding sites for an epitope may also be generated. For example, such fragments include, but are not limited to, the F(ab')2 fragments produced by pepsin digestion of the antibody molecule, and the Fab fragments generated by reducing the disulfide bridges of the F(ab')2 fragments. Alternatively, construction of Fab expression libraries in filamentous bacteriophage allows rapid and easy identification of monoclonal fragments with desired specificity (Pound, supra. Chaps. 45-47). Antibodies generated against polypeptide encoded by mddt can be used to purify and characterize full-length MDDT protein and its activity, binding partners, etc. Assays Using Antibodies Anti-MDDT antibodies may be used in assays to quantify the amount of MDDT found in a particular human cell. Such assays include methods utilizing the antibody and a label to detect expression level under normal or disease conditions. The peptides and antibodies of the invention may be used with or without modification or labeled by joining them, either covalently or noncovalently, with a reporter molecule. Protocols for detecting and measuring protein expression using either polyclonal or monoclonal antibodies are well known in the art. Examples include ELISA, RIA, and fluorescent activated cell sorting (FACS). Such immunoassays typically involve the formation of complexes between the MDDT and its specific antibody and the measurement of such complexes. These and other assays are described in Pound (supra). Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever. The disclosures of all patents, applications, and publications mentioned above and below, including U.S. Serial No. 60/230,517, U.S. Serial No. 60/230,599, U.S. Serial No. 60/230,514, U.S. Serial No. 60/231 , 167, U.S. Serial No. 60/230,598, U.S. Serial No. 60/230,988, U.S. Serial No. 60/230,518, U.S. Serial No. 60/230,515, U.S. Serial No. 60/229,751 , U.S. Serial No. 60/230,610, U.S. Serial No. 60/229,749, U.S. Serial No. 60/229,750, U.S. Serial No. 60/230,597, U.S. Serial No. 60/230,505, U.S. Serial No. 60/231 ,163, U.S. Serial No. 60/229,747, U.S. Serial No. 60/229 * ,748, U.S. Serial No. 60/230,583, U.S. Serial No. 60/230,519, U.S. Serial No. 60/230,595, U.S. Serial No. 60/230,865, U.S. Serial No. 60/230,989, and U.S. Serial No. 60/230,951 , are hereby expressly incoφorated by reference. EXAMPLES I. Construction of cDNA Libraries RNA was purchased from CLONTECH Laboratories, Inc. (Palo Alto CA) or isolated from various tissues. Some tissues were homogenized and lysed in guanidinium isothiocyanate, while others were homogenized and lysed in phenol or in a suitable mixture of denaturants, such as TRIZOL (Life Technologies), a monophasic solution of phenol and guanidine isothiocyanate. The resulting lysates were centrifuged over CsCI cushions or extracted with chloroform. RNA was precipitated with either isopropanol or sodium acetate and ethanol, or by other routine methods. Phenol extraction and precipitation of RNA were repeated as necessary to increase RNA purity. In most cases, RNA was treated with DNase. For most libraries, poly(A+) RNA was isolated using oligo d(T)-coupled paramagnetic particles (Promega Coφoration (Promega), Madison WI), OLIGOTEX latex particles (QIAGEN, Inc. (QIAGEN), Valencia CA), or an OLIGOTEX mRNA purification kit (QIAGEN). Alternatively, RNA was isolated directly from tissue lysates using other RNA isolation kits, e.g., the POLY(A)PURE mRNA purification kit (Ambion, Inc., Austin TX). In some cases, Stratagene was provided with RNA and constructed the corresponding cDNA libraries. Otherwise, cDNA was synthesized and cDNA libraries were constructed with the UNIZAP vector system (Stratagene Cloning Systems, Inc. (Stratagene), La Jolla CA) or SUPERSCRIPT plasmid system (Life Technologies), using the recommended procedures or similar methods known in the art. (See, e.g., Ausubel, 1997, supra. Chapters 5.1 through 6.6.) Reverse transcription was initiated using oligo d(T) or random primers. Synthetic oligonucleotide adapters were ligated to double stranded cDNA, and the cDNA was digested with the appropriate restriction enzyme or enzymes. For most libraries, the cDNA was size-selected (300-1000 bp) using SEPHACRYL SI 000, SEPHAROSE CL2B, or SEPHAROSE CL4B column chromatography (Amersham Pharmacia Biotech) or preparative agarose gel electrophoresis. cDNAs were ligated into compatible restriction enzyme sites of the polylinker of a suitable plasmid, e.g., PBLUESCRIPT plasmid (Stratagene), PSPORT1 plasmid (Life Technologies), PCDNA2.1 plasmid (Invitrogen, Carlsbad CA), PBK-CMV plasmid (Stratagene), or pINCY (Incyte Genomics, Palo Alto CA), or derivatives thereof. Recombinant plasmids were transformed into competent E. coli cells including XLl -Blue, XLl-BlueMRF, or SOLR from Stratagene or DH5α, DH10B, or ElectroMAX DH10B from Life Technologies. II. Isolation of cDNA Clones Plasmids were recovered from host cells by in vivo excision using the UNIZAP vector system (Stratagene) or by cell lysis. Plasmids were purified using at least one of the following: the Magic or WIZARD Minipreps DNA purification system (Promega); the AGTC Miniprep purification kit (Edge BioSystems, Gaithersburg MD); and the QIAWELL 8, QIAWELL 8 Plus, and QIAWELL 8 Ultra plasmid purification systems or the R.E.A.L. PREP 96 plasmid purification kit (QIAGEN). Following precipitation, plasmids were resuspended in 0.1 ml of distilled water and stored, with or without lyophilization, at 4°C. Alternatively, plasmid DNA was amplified from host cell lysates using direct link PCR in a high-throughput format. (Rao, V.B. (1994) Anal. Biochem. 216: 1 -14.) Host cell lysis and thermal cycling steps were carried out in a single reaction mixture. Samples were processed and stored in 384-well plates, and the concentration of amplified plasmid DNA was quantified fluorometrically using PICOGREEN dye (Molecular Probes, Inc. (Molecular Probes), Eugene OR) and a FLUOROSKAN II fluorescence scanner (Labsystems Oy, Helsinki, Finland). III. Sequencing and Analysis cDNA sequencing reactions were processed using standard methods or high-throughput instrumentation such as the ABI CATALYST 800 thermal cycler (Applied Biosystems) or the PTC- 200 thermal cycler (MJ Research) in conjunction with the HYDRA microdispenser (Robbins Scientific Corp., Sunnyvale CA) or the MICROLAB 2200 liquid transfer system (Hamilton). cDNA sequencing reactions were prepared using reagents provided by Amersham Pharmacia Biotech or supplied in ABI sequencing kits such as the ABI PRISM BIGDYE Terminator cycle sequencing ready reaction kit (Applied Biosystems). Electrophoretic separation of cDNA sequencing reactions and detection of labeled polynucleotides were carried out using the MEGABACE 1000 DNA sequencing system (Molecular Dynamics); the ABI PRISM 373 or 377 sequencing system (Applied Biosystems) in conjunction with standard ABI protocols and base calling software; or other sequence analysis systems known in the art. Reading frames within the cDNA sequences were identified using standard methods (reviewed in Ausubel, 1997, supra. Chapter 7.7). Some of the cDNA sequences were selected for extension using the techniques disclosed in Example VIII. IV. Assembly and Analysis of Sequences Component sequences from chromatograms were subject to PHRED analysis and assigned a quality score. The sequences having at least a required quality score were subject to various pre- processing editing pathways to eliminate, e.g., low quality 3' ends, vector and linker sequences, polyA tails, Alu repeats, mitochondrial and ribosomal sequences, bacterial contamination sequences, and sequences smaller than 50 base pairs. In particular, low-information sequences and repetitive elements (e.g., dinucleotide repeats, Alu repeats, etc.) were replaced by "n's", or masked, to prevent spurious matches. Processed sequences were then subject to assembly procedures in which the sequences were assigned to gene bins (bins). Each sequence could only belong to one bin. Sequences in each gene bin were assembled to produce consensus sequences (templates). Subsequent new sequences were added to existing bins using BLASTn (v.1.4 WashU) and CROSSMATCH. Candidate pairs were identified as all BLAST hits having a quality score greater than or equal to 150. Alignments of at least 82% local identity were accepted into the bin. The component sequences from each bin were assembled using a version of PHRAP. Bins with several overlapping component sequences were assembled using DEEP PHRAP. The orientation (sense or antisense) of each assembled template was determined based on the number and orientation of its component sequences. Template sequences as disclosed in the sequence listing correspond to sense strand sequences (the "forward" reading frames), to the best determination. The complementary (antisense) strands are inherently disclosed herein. The component sequences which were used to assemble each template consensus sequence are listed in Table 5, along with their positions along the template nucleotide sequences. Bins were compared against each other and those having local similarity of at least 82% were combined and reassembled. Reassembled bins having templates of insufficient overlap (less than 95% local identity) were re-split. Assembled templates were also subject to analysis by STITCHER/EXON MAPPER algorithms which analyze the probabilities of the presence of splice variants, alternatively spliced exons, splice junctions, differential expression of alternative spliced genes across tissue types or disease states, etc. These resulting bins were subject to several rounds of the above assembly procedures. Once gene bins were generated based upon sequence alignments, bins were clone joined based upon clone information. If the 5' sequence of one clone was present in one bin and the 3' sequence from the same clone was present in a different bin, it was likely that the two bins actually belonged together in a single bin. The resulting combined bins underwent assembly procedures to regenerate the consensus sequences. The final assembled templates were subsequently annotated using the following procedure. Template sequences were analyzed using BLASTn (v2.0, NCBI) versus gbpri (GenBank version 124). "Hits" were defined as an exact match having from 95% local identity over 200 base pairs through 100% local identity over 100 base pairs, or a homolog match having an E-value, i.e. a probability score, of < 1 x 10' 8 . The hits were subject to frameshift FASTx versus GENPEPT (GenBank version 124). (See Table 8). In this analysis, a homolog match was defined as having an E-value of < 1 x 10 s . The assembly method used above was described in "System and Methods for Analyzing Biomolecular Sequences," U.S.S.N. 09/276,534, filed March 25, 1999, and the LIFESEQ Gold user manual (Incyte) both incorporated by reference herein. Following assembly, template sequences were subjected to motif, BLAST, and functional analyses, and categorized in protein hierarchies using methods described in, e.g., "Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data," U.S.S.N. 08/812,290, filed March 6, 1997; "Relational Database for Storing Biomolecule Information," U.S.S.N. 08/947,845, filed October 9, 1997; "Project-Based Full-Length Biomolecular Sequence Database," U.S.S.N. 08/81 1,758, filed March 6, 1997; and "Relational Database and System for Storing Information Relating to Biomolecular Sequences," U.S.S.N. 09/034,807, filed March 4, 1998, all of which are incoφorated by reference herein. The template sequences were further analyzed by translating each template in all three forward reading frames and searching each translation against the Pfam database of hidden Markov model-based protein families and domains using the HMMER software package (available to the public from Washington University School of Medicine, St. Louis MO). Regions of templates which, when translated, contain similarity to Pfam consensus sequences are reported in Table 3, along with descriptions of Pfam protein domains and families. Only those Pfam hits with an E-value of ≤ 1 x 10 "3 are reported. (See also World Wide Web site http://pfam.wustl.edu/ for detailed descriptions of Pfam protein domains and families.) Additionally, the template sequences were translated in all three forward reading frames, and each translation was searched against hidden Markov models for signal peptides using the HMMER software package. Construction of hidden Markov models and their usage in sequence analysis has been described. (See, for example, Eddy, S.R. (1996) Curr. Opin. Str. Biol. 6:361-365.) Only those signal peptide hits with a cutoff score of 1 1 bits or greater are reported. A cutoff score of 1 1 bits or greater corresponds to at least about 91-94% true-positives in signal peptide prediction. Template sequences were also translated in all three forward reading frames, and each translation was searched against TMAP, a program that uses weight matrices to delineate transmembrane segments on protein sequences and determine orientation, with respect to the cell cytosol (Persson, B. and P. Argos (1994) J. Mol. Biol. 237: 182-192; Persson, B. and P. Argos (1996) Protein Sci. 5:363-371.) Regions of templates which, when translated, contain similarity to signal peptide or transmembrane consensus sequences are reported in Table 4. The results of HMMER analysis as reported in Tables 3 and 4 may support the results of BLAST analysis as reported in Table 2 or may suggest alternative or additional properties of template- encoded polypeptides not previously uncovered by BLAST or other analyses. Template sequences are further analyzed using the bioinformatics tools listed in Table 8, or using sequence analysis software known in the art such as MACDNASIS PRO software (Hitachi Software Engineering, South San Francisco CA) and LASERGENE software (DNASTAR). Template sequences may be further queried against public databases such as the GenBank rodent, mammalian, vertebrate, prokaryote, and eukaryote databases. The template sequences were translated to derive the corresponding longest open reading frame as presented by the polypeptide sequences as reported in Table 2. Alternatively, a polypeptide of the invention may begin at any of the mefhionine residues within the full length translated polypeptide. Polypeptide sequences were subsequently analyzed by querying against the GenBank protein database (GENPEPT, (GenBank version 124)). Full length polynucleotide sequences are also analyzed using MACDNASIS PRO software (Hitachi Software Engineering, South San Francisco CA) and LASERGENE software (DNASTAR). Polynucleotide and polypeptide sequence alignments are generated using default parameters specified by the CLUSTAL algorithm as incoφorated into the MEGALIGN multisequence alignment program (DNASTAR), which also calculates the percent identity between aligned sequences. Table 7 shows sequences with homology to the polypeptides of the invention as identified by BLAST analysis against the GenBank protein (GENPEPT) database. Column 1 shows the polypeptide sequence identification number (SEQ ID NO:) for the polypeptide segments of the invention. Column 2 shows the reading frame used in the translation of the polynucleotide sequences encoding the polypeptide segments. Column 3 shows the length of the translated polypeptide segments. Columns 4 and 5 show the start and stop nucleotide positions of the polynucleotide sequences encoding the polypeptide segments. Column 6 shows the GenBank identification number (GI Number) of the nearest GenBank homolog. Column 7 shows the probability score for the match between each polypeptide and its GenBank homolog. Column 8 shows the annotation of the GenBank homolog. V. Analysis of Polynucleotide Expression Northern analysis is a laboratory technique used to detect the presence of a transcript of a gene and involves the hybridization of a labeled nucleotide sequence to a membrane on which RNAs from a particular cell type or tissue have been bound. (See, e.g., Sambrook, supra, ch. 7; Ausubel, 1995, supra, ch. 4 and 16.) Analogous computer techniques applying BLAST were used to search for identical or related molecules in cDNA databases such as GenBank or LIFESEQ (Incyte Genomics). This analysis is much faster than multiple membrane-based hybridizations. In addition, the sensitivity of the computer search can be modified to determine whether any particular match is categorized as exact or similar. The basis of the search is the product score, which is defined as: BLAST Score x Percent Identity 5 x minimum { length(Seq. 1 ), length(Seq. 2) } The product score takes into account both the degree of similarity between two sequences and the length of the sequence match. The product score is a normalized value between 0 and 100, and is calculated as follows: the BLAST score is multiplied by the percent nucleotide identity and the product is divided by (5 times the length of the shorter of the two sequences). The BLAST score is calculated by assigning a score of +5 for every base that matches in a high-scoring segment pair (HSP), and -4 for every mismatch. Two sequences may share more than one HSP (separated by gaps). If there is more than one HSP, then the pair with the highest BLAST score is used to calculate the product score. The product score represents a balance between fractional overlap and quality in a BLAST alignment. For example, a product score of 100 is produced only for 100% identity over the entire length of the shorter of the two sequences being compared. A product score of 70 is produced either by 100% identity and 70% overlap at one end, or by 88% identity and 100% overlap at the other. A product score of 50 is produced either by 100% identity and 50% overlap at one end, or 79% identity and 100% overlap. VI. Tissue Distribution Profiling A tissue distribution profile is determined for each template by compiling the cDNA library tissue classifications of its component cDNA sequences. Each component sequence, is derived from a cDNA library constructed from a human tissue. Each human tissue is classified into one of the following categories: cardiovascular system; connective tissue; digestive system; embryonic structures; endocrine system; exocrine glands; genitalia, female; genitalia, male; germ cells; hemic and immune system; liver; musculoskeletal system; nervous system; pancreas; respiratory system, sense organs; skin; stomatognathic system; unclassified/mixed; or urinary tract. Template sequences, component sequences, and cDNA library /tissue information are found in the LIFESEQ GOLD database (Incyte Genomics, Palo Alto CA). Table 6 shows the tissue distribution profile for the templates of the invention. For each template, the three most frequently observed tissue categories are shown in column 3, along with the percentage of component sequences belonging to each category. Only tissue categories with percentage values of ≥10% are shown. A tissue distribution of "widely distributed" in column 3 indicates percentage values of <10% in all tissue categories. VII. Transcript Image Analysis Transcript images are generated as described in Seilhamer et al., "Comparative Gene Transcript Analysis," U.S. Patent Number 5,840,484, incoφorated herein by reference. VIII. Extension of Polynucleotide Sequences and Isolation of a Full-length cDNA Oligonucleotide primers designed using an mddt of the Sequence Listing are used to extend the nucleic acid sequence. One primer is synthesized to initiate 5' extension of the template, and the other primer, to initiate 3' extension of the template. The initial primers may be designed using OLIGO 4.06 software (National Biosciences, Inc. (National Biosciences), Plymouth MN), or another appropriate program, to be about 22 to 30 nucleotides in length, to have a GC content of about 50% or more, and to anneal to the target sequence at temperatures of about 68°C to about 72°C. Any stretch of nucleotides which would result in haiφin structures and primer-primer dimerizations are avoided. Selected human cDNA libraries are used to extend the sequence. If more than one extension is necessary or desired, additional or nested sets of primers are designed. High fidelity amplification is obtained by PCR using methods well known in the art. PCR is performed in 96-well plates using the PTC-200 thermal cycler (MJ Research). The reaction mix contains DNA template, 200 nmol of each primer, reaction buffer containing Mg 2 \ (NH 4 ) 2 S0 4 , and β - mercaptoethanol, Taq DNA polymerase (Amersham Pharmacia Biotech), ELONGASE enzyme (Life Technologies), and Pfu DNA polymerase (Stratagene), with the following parameters for primer pair PCI A and PCI B: Step 1 : 94°C, 3 min; Step 2: 94°C, 15 sec; Step 3: 60°C, 1 min; Step 4: 68°C, 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68°C, 5 min; Step 7: storage at 4°C. In the alternative, the parameters for primer pair T7 and SK+ are as follows: Step 1 : 94°C, 3 min; Step 2: 94°C, 15 sec; Step 3: 57°C, 1 min; Step 4: 68°C, 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68°C, 5 min; Step 7: storage at 4°C. The concentration of DNA in each well is determined by dispensing 100 μl PICOGREEN quantitation reagent (0.25% (v/v); Molecular Probes) dissolved in IX Tris-EDTA (TE) and 0.5 μl of undiluted PCR product into each well of an opaque fluorimeter plate (Coming Incoφorated (Coming), Co ing NY), allowing the DNA to bind to the reagent. The plate is scanned in a FLUOROSKAN II (Labsystems Oy) to measure the fluorescence of the sample and to quantify the concentration of DNA. A 5 μl to 10 μl aliquot of the reaction mixture is analyzed by electrophoresis on a 1 % agarose mini-gel to determine which reactions are successful in extending the sequence. The extended nucleotides are desalted and concentrated, transferred to 384-well plates, digested with CviJI cholera virus endonuclease (Molecular Biology Research, Madison WI), and sonicated or sheared prior to religation into pUC 18 vector (Amersham Pharmacia Biotech). For shotgun sequencing, the digested nucleotides are separated on low concentration (0.6 to 0.8%) agarose gels, fragments are excised, and agar digested with AGAR ACE (Promega). Extended clones are religated using T4 ligase (New England Biolabs, Inc., Beverly MA) into pUC 18 vector (Amersham Pharmacia Biotech), treated with Pfu DNA polymerase (Stratagene) to fill-in restriction site overhangs, and transfected into competent E. coli cells. Transformed cells are selected on antibiotic-containing media, individual colonies are picked and cultured overnight at 37°C in 384-well plates in LB/2x carbenicillin liquid media. The cells are lysed, and DNA is amplified by PCR using Taq DNA polymerase (Amersham Pharmacia Biotech) and Pfu DNA polymerase (Stratagene) with the following parameters: Step 1 : 94°C, 3 min; Step 2: 94°C, 15 sec; Step 3: 60°C, 1 min; Step 4: 72°C, 2 min; Step 5: steps 2, 3, and 4 repeated 29 times; Step 6: 72°C, 5 min; Step 7: storage at 4°C. DNA is quantified by PICOGREEN reagent (Molecular Probes) as described above. Samples with low DNA recoveries are reamplified using the same conditions as described above. Samples are diluted with 20% dimethysulfoxide (1 :2, v/v), and sequenced using DYENAMIC energy transfer sequencing primers and the DYENAMIC DIRECT kit (Amersham Pharmacia Biotech) or the ABI PRISM BIGDYE Terminator cycle sequencing ready reaction kit (Applied Biosystems). In like manner, the mddt is used to obtain regulatory sequences (promoters, introns, and enhancers) using the procedure above, oligonucleotides designed for such extension, and an appropriate genomic library. IX. Labeling of Probes and Southern Hybridization Analyses Hybridization probes derived from the mddt of the Sequence Listing are employed for screening cDNAs, mRNAs, or genomic DNA. The labeling of probe nucleotides between 100 and 1000 nucleotides in length is specifically described, but essentially the same procedure may be used with larger cDNA fragments. Probe sequences are labeled at room temperature for 30 minutes using a T4 polynucleotide kinase, γ 32 P-ATP, and 0.5X One-Phor-All Plus (Amersham Pharmacia Biotech) buffer and purified using a ProbeQuant G-50 Microcolumn (Amersham Pharmacia Biotech). The probe mixture is diluted to 10 7 dpm/μg/ml hybridization buffer and used in a typical membrane-based hybridization analysis. The DNA is digested with a restriction endonuclease such as Eco RV and is electrophoresed through a 0.7% agarose gel. The DNA fragments are transferred from the agarose to nylon membrane (NYTRAN Plus, Schleicher & Schuell, Inc., Keene NH) using procedures specified by the manufacturer of the membrane. Prehybridization is carried out for three or more hours at 68 °C, and hybridization is carried out overnight at 68°C. To remove non-specific signals, blots are sequentially washed at room temperature under increasingly stringent conditions, up- to 0. Ix saline sodium citrate (SSC) and 0.5% sodium dodecyl sulfate. After the blots are placed in a PHOSPHORIMAGER cassette (Molecular Dynamics) or are exposed to autoradiography film, hybridization patterns of standard and experimental lanes are compared. Essentially the same procedure is employed when screening RNA. X. Chromosome Mapping of mddt The cDNA sequences which were used to assemble SEQ ID NO: 1 -252 are compared with sequences from the Incyte LIFESEQ database and public domain databases using BLAST and other implementations of the Smith-Waterman algorithm. Sequences from these databases that match SEQ ID NO: 1-252 are assembled into clusters of contiguous and overlapping sequences using assembly algorithms such as PHRAP (Table 8). Radiation hybrid and genetic mapping data available from public resources such as the Stanford Human Genome Center (SHGC), Whitehead Institute for Genome Research (WIGR), and Genethon are used to determine if any of the clustered sequences have been previously mapped. Inclusion of a mapped sequence in a cluster will result in the assignment of all sequences of that cluster, including its particular SEQ ID NO:, to that map location. The genetic map locations of SEQ ID NO: 1 -252 are described as ranges, or intervals, of human chromosomes. The map position of an interval, in cenUMorgans, is measured relative to the terminus of the chromosome's p-arm. (The centiMorgan (cM) is a unit of measurement based on recombination frequencies between chromosomal markers. On average, 1 cM is roughly equivalent to 1 megabase (Mb) of DNA in humans, although this can vary widely due to hot and cold spots of recombination.) The cM distances are based on genetic markers mapped by Genethon which provide boundaries for radiation hybrid markers whose sequences were included in each of the clusters. XI. Microarray Analysis Probe Preparation from Tissue or Cell Samples Total RNA is isolated from tissue samples using the guanidinium thiocyanate method and polyA + RNA is purified using the oligo (dT) cellulose method. Each polyA + RNA sample is reverse transcribed using MMLV reverse-transcriptase, 0.05 pg/μl oligo-dT primer (21mer), IX first strand buffer, 0.03 units/μl RNase inhibitor, 500 μM dATP, 500 μM dGTP, 500 μM dTTP, 40 μM dCTP, 40 μM dCTP-Cy3 (BDS) or dCTP-Cy5 (Amersham Pharmacia Biotech). The reverse transcription reaction is performed in a 25 ml volume containing 200 ng polyA + RNA with GEMBRIGHT kits (Incyte). Specific control polyA + RNAs are synthesized by in vitro transcription from non-coding yeast genomic DNA (W. Lei, unpublished). As quantitative controls, the control RNAs at 0.002 ng, 0.02 ng, 0.2 ng, and 2 ng are diluted into reverse transcription reaction at ratios of 1 : 100,000, 1 : 10,000, 1 : 1000, 1 : 100 (w/w) to sample mRNA respectively. The control mRNAs are diluted into reverse transcription reaction at ratios of 1:3, 3:1, 1 :10, 10:1, 1 :25, 25:1 (w/w) to sample mRNA differential expression patterns. After incubation at 37° C for 2 hr, each reaction sample (one with Cy3 and another with Cy5 labeling) is treated with 2.5 ml of 0.5M sodium hydroxide and incubated for 20 minutes at 85° C to the stop the reaction and degrade the RNA. Probes are purified using two successive CHROMA SPIN 30 gel filtration spin columns (CLONTECH Laboratories, Inc. (CLONTECH), Palo Alto CA) and after combining, both reaction samples are ethanol precipitated using 1 ml of glycogen (1 mg/ml), 60 ml sodium acetate, and 300 ml of 100% ethanol. The probe is then dried to completion using a SpeedVAC (Savant Instmments Inc., Holbrook NY) and resuspended in 14 μl 5X SSC/0.2% SDS. Microarray Preparation Sequences of the present invention are used to generate array elements. Each array element is amplified from bacterial cells containing vectors with cloned cDNA inserts. PCR amplification uses primers complementary to the vector sequences flanking the cDNA insert. Array elements are amplified in thirty cycles of PCR from an initial quantity of 1-2 ng to a final quantity greater than 5 μg. Amplified array elements are then purified using SEPHACRYL-400 (Amersham Pharmacia Biotech). Purified array elements are immobilized on polymer-coated glass slides. Glass microscope slides (Co ing) are cleaned by ultrasound in 0.1% SDS and acetone, with extensive distilled water washes between and after treatments. Glass slides are etched in 4% hydrofluoric acid (VWR Scientific Products Coφoration (VWR), West Chester, PA), washed extensively in distilled water, and coated with 0.05% aminopropyl silane (Sigma) in 95% ethanol. Coated slides are cured in a 1 10°C oven. Array elements are applied to the coated glass substrate using a procedure described in US Patent No. 5,807,522, incoφorated herein by reference. 1 μl of the array element DNA, at an average concentration of 100 ng/μl, is loaded into the open capillary printing element by a high-speed robotic apparatus. The apparatus then deposits about 5 nl of array element sample per slide. Microarrays are UV-crosslinked using a STRATALINKER UV-crosslinker (Stratagene). Microarrays are washed at room temperature once in 0.2% SDS and three times in distilled water. Non-specific binding sites are blocked by incubation of microarrays in 0.2% casein in phosphate buffered saline (PBS) (Tropix, Inc., Bedford, MA) for 30 minutes at 60° C followed by washes in 0.2% SDS and distilled water as before. Hybridization Hybridization reactions contain 9 μl of probe mixture consisting of 0.2 μg each of Cy3 and Cy5 labeled cDNA synthesis products in 5X SSC, 0.2% SDS hybridization buffer. The probe mixture is heated to 65° C for 5 minutes and is aliquoted onto the microarray surface and covered with an 1.8 cm 2 coverslip. The arrays are transferred to a wateφroof chamber having a cavity just slightly larger than a microscope slide. The chamber is kept at 100% humidity internally by the addition of 140 μl of 5x SSC in a comer of the chamber. The chamber containing the arrays is incubated for about 6.5 hours at 60°C. The arrays are washed for 10 min at 45°C in a first wash buffer (IX SSC, .0.1 % SDS), three times for 10 minutes each at 45° C in a second wash buffer (0.1X SSC), and dried. Detection Reporter-labeled hybridization complexes are detected with a microscope equipped with an Innova 70 mixed gas 10 W laser (Coherent, Inc., Santa Clara CA) capable of generating spectral lines at 488 nm for excitation of Cy3 and at 632 nm for excitation of Cy5. The excitation laser light is focused on the array using a 20X microscope objective (Nikon, Inc., Melville NY). The slide containing the array is placed on a computer-controlled X-Y stage on the microscope and raster- scanned past the objective. The 1.8 cm x 1.8 cm array used in the present example is scanned with a resolution of 20 micrometers. In two separate scans, a mixed gas multiline laser excites the two fluorophores sequentially. Emitted light is split, based on wavelength, into two photomultiplier tube detectors (PMT R1477, Hamamatsu Photonics Systems, Bridgewater NJ) corresponding to the two fluorophores. Appropriate filters positioned between the array and the photomultiplier tubes are used to filter the signals. The emission maxima of the fluorophores used are 565 nm for Cy3 and 650 nm for Cy5. Each array is typically scanned twice, one scan per fluorophore using the appropriate filters at the laser source, although the apparatus is capable of recording the spectra from both fluorophores simultaneously. The sensitivity of the scans is typically calibrated using the signal intensity generated by a cDNA control species added to the probe mix at a known concentration. A specific location on the array contains a complementary DNA sequence, allowing the intensity of the signal at that location to be correlated with a weight ratio of hybridizing species of 1 : 100,000. When two probes from different sources (e.g., representing test and control cells), each labeled with a different fluorophore, are hybridized to a single array for the puφose of identifying genes that are differentially expressed, the calibration is done by labeling samples of the calibrating cDNA with the two fluorophores and adding identical amounts of each to the hybridization mixture. The output of the photomultiplier tube is digitized using a 12-bit RTI-835H analog-to-digital (A D) conversion board (Analog Devices, Inc., Norwood, MA) installed in an IBM-compatible PC computer. The digitized data are displayed as an image where the signal intensity is mapped using a linear 20-color transformation to a pseudocolor scale ranging from blue (low signal) to red (high signal). The data is also analyzed quantitatively. Where two different fluorophores are excited and measured simultaneously, the data are first corrected for optical crosstalk (due to overlapping emission spectra) between the fluorophores using each fluorophore 's emission spectrum. A grid is superimposed over the fluorescence signal image such that the signal from each spot is centered in each element of the grid. The fluorescence signal within each element is then integrated to obtain a numerical value corresponding to the average intensity of the signal. The software used for signal analysis is the GEMTOOLS gene expression analysis program (Incyte). XII. Complementary Nucleic Acids Sequences complementary to the mddt are used to detect, decrease, or inhibit expression of the naturally occurring nucleotide. The use of oligonucleotides comprising from about 15 to 30 base pairs is typical in the art. However, smaller or larger sequence fragments can also be used. Appropriate oligonucleotides are designed from the mddt using OLIGO 4.06 software (National Biosciences) or other appropriate programs and are synthesized using methods standard in the art or ordered from a commercial supplier. To inhibit transcription, a complementary oligonucleotide is designed from the most unique 5' sequence and used to prevent transcription factor binding to the promoter sequence. To inhibit translation, a complementary oligonucleotide is designed to prevent ribosomal binding and processing of the transcript. XIII. Expression of MDDT Expression and purification of MDDT is accomplished using bacterial or vims-based expression systems. For expression of MDDT in bacteria, cDNA is subcloned into an appropriate vector containing an antibiotic resistance gene and an inducible promoter that directs high levels of cDNA transcription Examples of such promoters include, but are not limited to, the trp-lac (tac) hybrid promoter and the T5 or T7 bacteriophage promoter in conjunction with the lac operator regulatory element Recombinant vectors are transformed into suitable bacterial hosts, e.g , BL21(DE3). Antibiotic resistant bacteria express MDDT upon induction with isopropyl beta-D- thiogalactopyranoside (IPTG). Expression of MDDT in eukaryotic cells is achieved by infecting insect or mammalian cell lines with recombinant Autographica californica nuclear polyhedrosis vims (AcMNPV), commonly known as baculovirus The nonessential polyhedrin gene of baculovirus is replaced with cDNA encoding MDDT by either homologous recombination or bacterial-mediated transposition involving transfer plasmid intermediates. Viral infectivity is maintained and the strong polyhedrin promoter drives high levels of cDNA transcription Recombinant baculovirus is used to infect Spodoptera frugiperda (Sf9) insect cells in most cases, or human hepatocytes, in some cases. Infection of the latter requires additional genetic modifications to baculovirus. (See e.g , Engelhard, supra, and Sandig, supra.) In most expression systems, MDDT is synthesized as a fusion protein with, e.g., glutathione S- transferase (GST) or a peptide epitope tag, such as FLAG or 6-His, permitting rapid, single-step, affinity-based purification of recombinant fusion protein from cmde cell lysates GST, a 26-kilodalton enzyme from Schistosoma laponicum, enables the purification of fusion proteins on immobilized glutathione under conditions that maintain protein activity and antigenicity (Amersham Pharmacia Biotech) Following purification, the GST moiety can be proteolytically cleaved from MDDT at specifically engineered sites FLAG, an 8-amino acid peptide, enables immunoaffinity purification using commercially available monoclonal and polyclonal anti-FLAG antibodies (Eastman Kodak Company, Rochester NY). 6-His, a stretch of six consecutive histidine residues, enables purification on metal-chelate resins (QIAGEN) Methods for protein expression and purification are discussed in Ausubel (1995, supra. Chapters 10 and 16). Purified MDDT obtained by these methods can be used directly in the following activity assay XIV. Demonstration of MDDT Activity MDDT, or biologically active fragments thereof, are labeled with l25 I Bolton-Hunter reagent. (See, e.g , Bolton, A E and W.M Hunter (1973) Biochem J 133 529-539 ) Candidate molecules previously arrayed in the wells of a multi-well plate are incubated with the labeled MDDT, washed, and any wells with labeled MDDT complex are assayed Data obtained using different concentrations of MDDT are used to calculate values for the number, affinity, and association of MDDT with the candidate molecules. Alternatively, molecules interacting with MDDT are analyzed using the yeast two-hybrid system as described in Fields, S. and O. Song (1989) Nature 340:245-246, or using commercially available kits based on the two-hybrid system, such as the MATCHMAKER system (CLONTECH). MDDT may also be used in the PATHCALLING process (CuraGen Coφ., New Haven CT) which employs the yeast two-hybrid system in a high-throughput manner to determine all interactions between the proteins encoded by two large libraries of genes (Nandabalan, K. et al. (2000) U.S. Patent No. 6,057,101 ). XV. Functional Assays MDDT function is assessed by expressing mddt at physiologically elevated levels in mammalian cell culture systems. cDNA is subcloned into a mammalian expression vector containing a strong promoter that drives high levels of cDNA expression. Vectors of choice include pCMV SPORT (Life Technologies) and pCR3.1 (Invitrogen Coφoration, Carlsbad CA), both of which contain the cytomegalovirus promoter. 5-10 μg of recombinant vector are transiently transfected into a human cell line, preferably of endothelial or hematopoietic origin, using either liposome formulations or electroporation. 1 -2 μg of an additional plasmid containing sequences encoding a marker protein are co-transfected. Expression of a marker protein provides a means to distinguish transfected cells from nontransfected cells and is a reliable predictor of cDNA expression from the recombinant vector. Marker proteins of choice include, e.g., Green Fluorescent Protein (GFP; CLONTECH), CD64, or a CD64-GFP fusion protein. Flow cytometry (FCM), an automated laser optics-based technique, is used to identify transfected cells expressing GFP or CD64-GFP and to evaluate the apoptotic state of the cells and other cellular properties. FCM detects and quantifies the uptake of fluorescent molecules that diagnose events preceding or coincident with cell death. These events include changes in nuclear DNA content as measured by staining of DNA with propidium iodide; changes in cell size and granularity as measured by forward light scatter and 90 degree side light scatter; down-regulation of DNA synthesis as measured by decrease in bromodeoxyuridine uptake; alterations in expression of cell surface and intracellular proteins as measured by reactivity with specific antibodies; and alterations in plasma membrane composition as measured by the binding of fluorescein-conjugated Annexin V protein to the cell surface. Methods in flow cytometry are discussed in Ormerod, M. G. (1994) Flow Cytometry. Oxford, New York NY. The influence of MDDT on gene expression can be assessed using highly purified populations of cells transfected with sequences encoding MDDT and either CD64 or CD64-GFP. CD64 and CD64-GFP are expressed on the surface of transfected cells and bind to conserved regions of human immunoglobulin G (IgG). Transfected cells are efficiently separated from nontransfected cells using magnetic beads coated with either human IgG or antibody against CD64 (DYNAL, Inc., Lake Success NY). mRNA can be purified from the cells using methods well known by those of skill in the art. Expression of mRNA encoding MDDT and other genes of interest can be analyzed by northern analysis or microarray techniques. XVI. Production of Antibodies MDDT substantially purified using polyacrylamide gel electrophoresis (PAGE; see, e.g., Harrington, M.G. (1990) Methods Enzymol. 182:488-495), or other purification techniques, is used to immunize rabbits and to produce antibodies using standard protocols. Alternatively, the MDDT amino acid sequence is analyzed using LASERGENE software (DNASTAR) to determine regions of high immunogenicity, and a corresponding peptide is synthesized and used to raise antibodies by means known to those of skill in the art. Methods for selection of appropriate epitopes, such as those near the C-terminus or in hydrophilic regions are well described in the art. (See, e.g., Ausubel, 1995, supra. Chapter 1 1.) Typically, peptides 15 residues in length are synthesized using an ABI 431 A peptide synthesizer (Applied Biosystems) using fmoc -chemistry and coupled to KLH (Sigma) by reaction with N-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) to increase immunogenicity. (See, e.g., Ausubel, supra.) Rabbits are immunized with the peptide-KLH complex in complete Freund's adjuvant. Resulting antisera are tested for antipeptide activity by, for example, binding the peptide to plastic, blocking with 1 % BSA, reacting with rabbit antisera, washing, and reacting with radioiodinated goat anti-rabbit IgG. Antisera with antipeptide activity are tested for anti-MDDT activity using protocols well known in the art, including ELISA, RIA, and immunoblotting. XVII. Purification of Naturally Occurring MDDT Using Specific Antibodies Naturally occurring or recombinant MDDT is substantially purified by immunoaffinity chromatography using antibodies specific for MDDT. An immunoaffinity column is constructed by covalently coupling anti-MDDT antibody to an activated chromatographic resin, such as CNBr-activated SEPHAROSE (Amersham Pharmacia Biotech). After the coupling, the resin is blocked and washed according to the manufacturer's instmctions. Media containing MDDT are passed over the immunoaffinity column, and the column is washed under conditions that allow the preferential absorbance of MDDT (e.g., high ionic strength buffers in the presence of detergent). The column is eluted under conditions that disrupt antibody/MDDT binding (e.g., a buffer of pH 2 to pH 3, or a high concentration of a chaotrope, such as urea or thiocyanate ion), and MDDT is collected. All publications and patents mentioned in the above specification are herein incoφorated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. 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O Q αθ -o co co co C 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 '— ■— ■— ■— ■— r— r— G LU CO Q — 9- £ * h i_ Q n -j in Mo o o r- t. o g B ' O MO O Q '- O 'J LO O I^ OO O '— CN O - G o o < Q -~ ^ - M CM CN N CM C CN CM CM CM C O C C C C C ^ ^ ^ rr ' 1 Jt 'cr '^ 'ϊ ^l- ~ aC C C C C C C C C - c c c^ c c0 c0 c c c c 0 c c c c c c co c c c0 (n LU CO ό O ' -C.CO'ϊ-. Ors tOO- O '- C.rtgiOO oo oo oo oo oo cococo oo oo c >- θ- C θ- o _ o o — cN c 'tf O -o r . oo o O '— N c '-r - o r^ co o O '— tM n io o eo c o Q ^ ι Lθ θ - Lθ Lθ Lθ Lθ - co <) <) ) > <3 <) ) J ) 3 r^ r^ r^ r~. ι - r-- r^ r^- r^. r^- oo — c co c c co co c co co co co co co o co co co co co co c to co co c co co co co oo co co o r^ m n. O '- C. cO 'ϊ iO O M O' O '- C. c ^I LO O OO O O '- I C g iO O CO C> (> C> 0 0 0 0 0 0 0 0 0 0 ,— ■"" "~ " "" "~ — — — — — CN CN CN CM CN CN CN CN CN G UJ CO z Q O O — CN cO 'f -O O r^. cO O O '— CN oo CO O O- 0 0 0 0 0 0 0 0- 0 0 0 0 0 0 0 0 0 0 -— ■— •— . o c e. c. c c n co ^ ^t '^ '^ '!} ^ ^ ^ ^ ^ ^ ^ ^ G> ό Q c. . ( n <. n n o Λ w n ^ ^ ^ ^ ^ ^ ^ , ^ 't -) -) -) -) io ιo ιo -) -) io LU CO CO O < CO ^J LO -O r- CO O- O ■- (N ( ^ lO O N oo α O '- c. n i -xj CO O O ■— CN o ^J ■— r- CM CM CN CN CM CN CM CN CM CN CO CO CO CO CO CO CO CO a ^r ^r ^r LU CO CO O O r- 00 <00> t> oo OO ggcocococococoooggcococococoggcogggcoggggggco o . in o Mo o O '- c. o ^ w o MO O- O '- wn ^ io oo oO'- c. n ^ -x) Q ^ ^ ^ ^ ^ io io io -O Lo iO L L Q LQ <j <3 .o j ^D <3 <) 3 rN. r^ r^ rN. r^ r. r^ gggg8D_8D-gggggggggggggg8---8CLgggggggggg8CL8CLgg8--.8CL8Q- o CM c ^T LO -O r. cO O '— C 'Nt i -O r^ oo O '— CN CO 'T -O ' r-v CO O O '— CM C O O O O O O O O O O O O O O O O O O -— r— r— I— r— r— •— •— r- r- CM CM CN CM r- i— r- r- r- r- r- CM CN CN CN CN CN CN CN CN CN CN CN CM CM CN CM CN CN CN CM CN CN CN CN co o < • n- io o r-N oo o -— CN c ^T -o -o r oo O '— c Q 00 00 00 C0 00 00 O O O O O O O O ^ ^ ^ -- --. _ ' ' — — — -- * ' J J - J 5j iJ ^ iO iO iO iO §i i8O -8. α TABLE 2 SEQ ID NO: Template ID GI Number Probability Score Annotation 1 LG:150318.1 :2000SEP08 gl 1643581 0 Homo sapiens PR- domain containing protein 14 (PRDM14) mRNA, 2 LG:022529.1:2000SEP08 g10047272 Homo sapiens mRNA for KIAA1599 protein, partial eds. 3 LG:352559.1:2000SEP08 g13560887 1.00E-11 Homo sapiens EZFIT- related protein 1 mRNA, complete 4 LG:175223.1:2000SEP08 g10433955 1.00E-43 (fl) (Homo sapiens) unnamed protein 5 LG:476989.1:2000SEP08 g12407394 Homo sapiens tripartite motif protein TRIM7 gRIM7) mRNA, 6 LG:253268.7:2000SEP08 gl 2239368 0 Homo sapiens LYST- interacting protein LIP9 mRNA, partial 7 LG:401322.1:2000SEP08 g13623682 5.00E-26 Homo sapiens, tubulin alpha 1, clone MGC:2321, 8 LG:1328436.1:2000SEP08 g4589587 2.00E-55 Homo sapiens mRNA for KIAA0972 protein, complete 9 LG:475404.1:2000SEP08 g!0434194 0 Homo sapiens cDNA FU12606 fis, clone NT2RM4001483, moderately similar 10 LG: 1384132.1 :2000SEP08 g 14042849 1.00E-71 Homo sapiens cDNA FU1495 fis, clone PLACE4000156, moderately similar 11 LG:410804.18:2000SEP08 gl3543325 3.00E-74 Homo sapiens, hypothetical protein MGC8407, clone MGC: 1820, mRNA, complete 12 LG:1082306.1:2000SEP08 g13325336 0 Homo sapiens, clone MGC: 10520, mRNA, complete 13 LG:233814.4:2000SEP08 gl0434873 1.00E-166 Homo sapiens cDNA FU13044 fis, clone NT2RP3001355, weakly similar to TRICARBOXYLATE TRANSPORT TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 14 ' LG:977478.5:2000SEP08 g 12698000 0 Homo sapiens mRNA for KiAAl 728 protein, partial eds. 15 LG:025931.1 :2000SEP08 g 10436359 0 Homo sapiens CDNA FLJ1401 1 fis, clone Y79AA 1002472, weakly similar to 16 LG:885368.1 :2000SEP08 g440824 9.00E-60 (fl) (Arabidopsis thaliana) ribosomal 17 LG:1054900.1.2000SEP08 g 12052982 0 Homo sapiens mRNA; cDNA DKFZp434l1610 (from clone DKFZp434ll610); 18 LG:995186.2:2000SEP08 g 12052982 0 Homo sapiens mRNA; cDNA DKFZp434ll610 (from clone DKFZp434ll610); 19 LG:435048.23:2000SEP08 gl 0432866 1.00E-177 Homo sapiens cDNA FUl 1583 fis, clone HEMBA1003680, weakly similar to PUTATIVE AMINOPEPTIDASE ZK353.6 IN 20 LG:954859.1 :2000SEP08 g 10438224 1.00E-176 Homo sapiens cDNA: FU21990 fis, clone HEP06386. 21 LG:364370.1 :2000SEP08 g 14043150 1.00E-163 Homo sapiens, ribosomal protein LI 3, clone MGC: 15490, mRNA, 22 LG:1098789.1 :2000SEP08 g 14029703 1.00E-137 Homo sapiens myosin regulatory light chain 2 (MRLC2) mRNA, 23 LG:201540.2:2000SEP08 g 12407386 0 0 Homo sapiens tripartite motif protein TRIM5 isoform delta (TRIM5) mRNA, 24 LG:1077357.1 :2000SEP08 g 10436361 4.00E-66 Homo sapiens cDNA FU14012 fis, clone Y79AA 1002482, moderately similar TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 25 LG:1048846.4:2000SEP08 g10439974 1.00E-154 Homo sapiens cDNA: FLJ23327 fis, clone HEP! 2630, highly similar to HSZNF37 Homo sapiens ZNF37A 26 LG:336685.1:2000SEP08 g12697317 0 Homo sapiens partial mRNA for 27 LG:1076253.1.2000SEP08 g7959276 5.00E-34 Homo sapiens mRNA for KIAA1508 protein, partial eds. 28 LG:1400601.2:2000SEP08 g14042292 Homo sapiens cDNA FLJ 14636 fis, clone NT2RP2001233, weakly similar to 29 LG:1079092.3:2000SEP08 g12052982 6.00E-07 Homo sapiens mRNA; cDNA DKFZp434ll610 (from clone DKFZp434ll610); 30 LG:1086064.1 :2000SEP08 g10436361 3.00E-76 Homo sapiens cDNA FLJ14012 fis, clone Y79AA 1002482, moderately similar 31 LG:1400608.1 :2000SEP08 g 12052731 1.00E-175 Homo sapiens mRNA; cDNA DKFZp761G18121 (from clone DKFZp761G18121); 32 LG:399275.5:2000SEP08 g14042034 Homo sapiens cDNA FU 14486 fis, clone MAM MAI 002650, weakly similar to 33 LG:293943.1 :2000SEP08 g7022603 2.00E-24 (fl) (Homo sapiens) unnamed protein 34 LG:345884.1 :2000SEP08 gl3591711 Homo sapiens immunoglobulin receptor translocation associated protein 2b (IRTA2) mRNA, 35 LG:400967.1 :2000SEP08 g 10047182 1.00E-176 Homo sapiens mRNA for KIAA1559 protein, partial eds. 36 LG:02455ό.6:2000SEP08 gl 1999276 0 Homo sapiens solute carrier (SLC25A18) mRNA, complete eds; nuclear gene for TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 37 LG:081 189.3:2000SEP08 g 14325768 0 Homo sapiens mRNA for KIAA1776 protein (fibrillin3), 38 LG:018258.1 :2000SEP08 g 12832288 3.00E-97 0 (Mus musculus) 39 LG:450399.3:2000SEP08 g 13097599 l.OOE-10 Homo sapiens. Similar to ribosomal protein L23, clone IMAGE:3606198. 40 LG:451122.1 :2000SEP08 g6002102 2.00E-38 (fl) (Digitalis lanata) Acyl-CoA binding protein (ACBP) 41 LG:451682.1:2000SEP08 g867149ό 1.00E-134 (fl) (Orγza sativa) alpha 3 subunit of 20S proteasome 42 LG:238631.4:2000SEP08 g!2803994 0 Homo sapiens. Similar to HI.A class II region expressed gene KE2, clone MGC:4178, mRNA, 43 LG:236654.1 :2000SEP08 g 1 1558487 2.00E-08 Homo sapiens mRNA for B-cell lymphoma/leukae mia l l B (BCL1 1 B 44 LG:332655.1 :2000SEP08 g 12856559 7.00E-93 0 (Mus musculus) 45 LG:217396.2:2000SEP08 g 10047294 0 Homo sapiens mRNA for KIAA1610 protein, partial eds. 46 LG:090574.1 :2000SEP08 g 12845416 5.00E-37 0 (Mus musculus) 47 LG:202943.1 :2000SEP08 g 12060829 0 Homo sapiens serologically defined breast cancer antigen NY- BR-38 mRNA, 48 LG:236928.1:2000SEP08 g14388574 Macaca fascicularis brain cDNA clone:QtrA- 49 LG:215169.2:2000SEP08 g790349 1.00E-22 Ho o sapiens (clone NE68) gene 50 LG:410726.1:2000SEP08 g9963805 2.00E-17 Homo sapiens zinc finger protein ZNF287 (ZNF287) 51 LG:234372.2:2000SEP08 g10436854 0 Homo sapiens cDNA: FU20896 fis, clone ADKA03527. 52 LG:022629.1:2000SEP08 g13879442 1.00E-178 (fl) (Mus musculus) Similar to RIKEN CDNA 2310035M22 53 LG:068682.1:2000SEP08 g13898616 0 Homo sapiens serine/threonine protein kinase SSTK (SSTK) mRNA, TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 54 LG:222335.1 :2000SEP08 g 14250137 0 Homo sapiens, Similar to RIKEN cDNA 5730421 El 8 gene, clone 55 LG:331342.1 :2000SEP08 gl0434081 0 Homo sapiens cDNA FLJ 12538 fis, clone NT2RM4000356, moderately similar to RAS-RELΛTED 56 LG:021770.1 :2000SEP08 g9408105 2.00E-47 Homo sapiens dNT- 2 gene for mitochondrial 5'(3'> deoxyribonucleotid 57 LG:181607.9;2000SEP08 gl2834244 8.00E-91 0 (Mus musculus) 58 LG:1042768.1 :2000SEP08 g 13937982 1.00E- 180 Homo sapiens, translocase of inner mitochondrial membrane 17 (yeast) homolog A, clone MGC: 14756, 59 LG:282729.1 :2000SEP08 g!2314268 1.00E-107 (5' incom)(Homo sapiens) dJ14N1.2 (novel S-100/ICaBP type calcium binding domain 60 LG:998305.3:2000SEP08 g 12053098 6.00E-88 Homo sapiens mRNA; cDNA DKFZp434A171 (from clone DKFZp434A171); 61 LG: 1 135213.1 :2000SEP08 g6692607 2.00E-69 (fl) (Mus musculus) MGA protein 62 LG:267762.1 :2000SEP08 gl2854977 1.OOE-135 0(Mus musculus) 63 LG: 120744.1 :2000SEP08 g 12052773 0 Homo sapiens mRNA; cDNA DKFZp564B052 (from clone DKFZp564B052); 64 LG:403409.1 :2000SEP08 g8896163 0 Homo sapiens kinesin-like protein GAKIN mRNA, 65 LG:226874.3:2000SEP08 g3688393 3.00E-05 Homo sapiens mRNA for triple LIM 66 LG:1045521.4:2000SEP08 gl0436742 4.00E-58 Homo sapiens cDNA FU14310 fis, clone 67 LG:275876.1 :2000SEP08 g5912051 6.00E-30 (3' and 5' inco ) (Homo sapiens) TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 68 LG:475127.7:2000SEP08 g7294107 6.00E-44 (fl) (Drosophila melanogaster) CG4638 gene 69 LG: 157263.1.2000SEP08 g3047402 3.00E-40 (fl) (Homo sapiens) monocarboxylate transporter 2 70 LG:247382.7:2000SEP08 g4240292 5.00E-25 Homo sapiens mRNA for KIAA0902 protein, complete 71 LG:197367.5:2000SEP08 gl0172680 7.00E-14 (fl) (Bacillus halodurans) stage V sporulation protein C (peptidyl- 72 LG:218090.5:2000SEP08 g9295344 0 Ho o sapiens HSKM-B (HSKM-B) mRNA, complete 73 LG:216612.4:2000SEP08 g8655677 0 Homo sapiens mRNA; cDNA DKFZp547M236 (from clone 74 LG:197614.1 :2000SEP08 gl3358641 0 Macaca fascicularis brain 75 LG:378428.1 :2000SEP08 g7264026 0 (fl) (Homo sapiens) dJ876B 10.2 (novel protein (ortholog of 76 LG:28όό39.1 :2000SEP08 g 13383264 0 Homo sapiens mRNA for actin related protein, 77 LG:389870.1 :2000SEP08 g 14388335 9.00E-63 Macaca fascicularis brain cDNA clone:QflA- 78 LG:1387485.6:2000SEP08 g 10435209 0 Homo sapiens CDNA FU13261 fis, clone OVARC 1000885, weakly similar to OXIDOREDUCTASE 79 LG:230151.1 :2000SEP08 g8655647 Homo sapiens mRNA; cDNA DKFZp762M1 15 (from clone 80 LG:215158.5:2000SEP08 gl0440162 Homo sapiens cDNA: FU23465 fis, clone HSI 10904. 81 LG:235840.1 :2000SEP08 g 14042343 Homo sapiens cDNA FU 14666 fis, clone NT2RP2003000, weakly similar to TUMOR NECROSIS FACTOR, ALPHA- TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 82 LG:350272.1 :2000SEP08 g13477234 0 Homo sapiens. Similar to RIKEN CDNA 0610037N03 gene, clone 83 LG:232190.1:2000SEP08 g!0434968 1.00E-143 Homo sapiens cDNA FLJ13105 fis, clone NT2RP3002351, weakly similar to Human mRNA for NAD-dependent methylene tetrahydrofolate 84 LG:1068127.1:2000SEP08 gl0436724 1.00E-140 Homo sapiens cDNA FU 14297 fis, clone 85 LG:408751.3:2000SEP08 g8886024 0 Homo sapiens collapsin response mediator protein-5 (CRMP5) mRNA, 86 LG:1078933.1:2000SEP08 g!4042843 0 Homo sapiens cDNA FU 14954 fis, clone PLACE3000169, weakly similar to 87 LG:958731.1:2000SEP08 g9758769 6.00E-88 (fl) (Arabidopsis thaliana) 1 1 -beta- hydroxysteroid 88 LG:024125.5:2000SEP08 gl2052958 0 0 Homo sapiens mRNA; cDNA DKFZp566J2046 (from clone DKFZp566J2046); 89 LG:373637.3:2000SEP08 gl 1118740 0 Homo sapiens UGT1 gene locus, complete 90 LG:1053229.1:2000SEP08 g12804322 0 Homo sapiens, clone MGO4054, mRNA, complete 91 LG:248364.1:2000SEP08 g12847599 0 0 (Mus musculus) 92 LG:477130.1:2000SEP08 g6650751 1.00E-55 (fl)(Ceratopteris richardii) ribosomal 93 LG:113786.17:2000SEP08 g10440515 0 Homo sapiens mRNA for FU00106 protein, partial eds. 94 LG:347635.1 :2000SEP08 g11527996 0 Homo sapiens NOTCH2 protein (NOTCH2) mRNA, 95 LG:242966.4:2000SEP08 g9955987 0 Homo sapiens clone TCCCIA00164 TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 96 LG:217814.1 :2000SEP08 g 10438977 0 Homo sapiens cDNA: FU22551 fis, clone HSI00804. 97 LG:476452.1 :2000SEP08 g4126809 1.00E-121 (fl) (Oryza sativa) glyoxalase I 98 LG: 1 100657.1 :2000SEP08 g340298 1.00E-107 Human vasopressin mRNA, complete 99 LG: 1 132418.2:2000SEP08 g 12653472 2.00E-86 Homo sapiens, proteasome (prosome, macropain) subunit, beta type, 100 LG:1098570.1:2000SEP08 g35069 1.00E-171 H.sapiens RNA for nm23-H2 gene. 101 LG:1097987.1:2000SEP08 g9368838 Homo sapiens mRNA; cDNA DKFZp547l014 (from clone 102 LG:337818.2:2000SEP08 g!4042395 Homo sapiens cDNA FU 14699 fis, clone NT2RP2006571, moderately similar to CYTOCHROME 103 LG:1040582.1 :2000SEP08 gl3529277 1.00E-119 Homo sapiens, aldo-keto reductase family 1, member Al (aldehyde reductase), clone 104 LG:1099122.1:2000SEP08 g13097716 8.00E-86 Homo sapiens, guanine nucleotide binding protein (G protein), gamma 5, clone 105 LG:1327449.1 :2000SEP08 g14042109 2.00E-96 Homo sapiens cDNA FU 14531 fis, clone NT2RM2000371, weakly similar to POLYRIBONUCLEOTI DE 106 LG:227933.5:2000SEP08 g9280028 Macaca fascicularis brain 107 LG:1043709.2:2000SEP08 g12804588 4.00E-30 Homo sapiens, Similar to CG9172 gene product, clone MGC886, 108 LG:1099871.1 :2000SEP08 gl2652698 1.00E-154 Homo sapiens, purine-rich element binding protein B, clone MGC: 1947, TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 109 LG:1399139.4:2000SEP08 g 10437077 0 Homo sapiens cD A: FU21069 fis, clone CAS01594. 110 LG:236386.1:2000SEP08 gl3477131 6.00E-87 (fl) (Homo sapiens) SH3 and PX domain-containing 111 LG:1015157.1:2000SEP08 gl881781 5.00E-72 glyoxalase I (human, HeLa cells, mRNA Partial, 572 112 LG:1065433.1 :2000SEP08 g4589587 8.00E-29 Homo sapiens mRNA for KIAA0972 protein, complete 113 LG:236992.4:2000SEP08 gl2248381 0 Homo sapiens mRNA for SEMB, 114 LG:1071124.1 :2000SEP08 g13543418 0 Homo sapiens. Similar to zinc finger protein 304, clone MGC:4079, mRNA, 115 LG:206425.2:200OSEP08 g!2052883 2.00E-90 Homo sapiens mRNA; cDNA DKFZp564C2478 (from clone DKFZp564C2478); 116 LG:885747.2:2000SEP08 g 12804504 2.00E-49 Homo sapiens. Similar to ribosomal protein L31, clone MGC: 1641, mRNA, 1 17 LG: 1 140501.1 :2000SEP08 g!2052919 Homo sapiens mRNA; cDNA DKFZp564ll782 (from clone DKFZp564ll782); 1 18 LG:001239.1 :2000SEP08 g14164612 Homo sapiens sialic acid binding immunoglobulin- like lectin 10 1 19 LG:018980.1 :2000SEP08 g 10435149 Homo sapiens cDNA FU 13220 fis, clone NT2RP4002047, moderately similar to GTP-BINDING 120 LG:1083120.3:2000SEP08 g515786 3.00E-66 H.sapiens (MAR7) chromosome 19 DNA, 302bp. 121 LG:233258.3:2000SEP08 g 10433125 00 Homo sapiens cDNA FU 11790 fis, clone 122 LG:999062.1 :2000SEP08 g9759463 3.00E-60 (fl) (Arabidopsis thaliana) 40S 123 LG:887776.1 :2000SEP08 g342294 1.00E-66 Macaca mulatta serum albumin TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 124 LG: 1400301.2:2000SEP08 gl2751104 1.00E-23 Homo sapiens PNAS-130 mRNA, 125 LG:1329362,1:2000SEP08 g14042849 0 Homo sapiens cDNA FU 14959 fis, clone PLACE4000156, moderately similar 126 LG:1096498.1:2000SEP08 gl3097206 l.OOE-110 Homo sapiens, ribosomal protein, large, PI, clone MGC:5215, mRNA, 127 LG:1096337.1:2000SEP08 gl3097206 1.00E-121 Homo sapiens, ribosomal protein, large, PI, clone MGC:5215, mRNA, 128 LG:1400579.1:2000SEP08 gl0437945 4.00E-61 Homo sapiens cDNA: FU21781 fis, clone HEP00223. 129 LG: 1080091.1 :2000SEP08 gl0436724 1.00E-154 Homo sapiens cDNA FU 14297 fis, clone 130 LG:1082203.1:2000SEP08 g10439929 0 Homo sapiens cDNA: FU23296 fis, clone HEP10656. 131 LG:1084051.1 :2000SEP08 g6807586 1.00E-104 Novel human gene mapping to chomosome 1. 132 LG:1082393.1:2000SEP08 g10954043 0 Homo sapiens KRAB zinc finger protein ZFQR 133 LG:1086183.1:2000SEP08 g12655164 6.00E-58 Homo sapiens, zinc finger protein 256, clone MGC:1413, mRNA, complete 134 LG:1090268.1:2000SEP08 g13938479 0 Homo sapiens. Similar to hypothetical protein FU22301, clone 135 LG:1400597.5:2000SEP08 gl4250145 1.00E-156 Homo sapiens, hypothetical protein FU23407, clone MGC: 14819, mRNA, complete 136 LG:1080307.2:2000SEP08 gl4043840 2.00E-34 Homo sapiens, clone MGC: 14429, mRNA, complete 137 LG:1400603.2:2000SEP08 g4589565 4.00E-31 Homo sapiens mRNA for KIAA0961 protein, complete TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 138 LG:1052984.1.2000SEP08 g 13937998 0 Homo sapiens, Similar to DNA- binding protein, clone MGC: 14780, 139 LG: 1091259.1.2000SEP08 gl0436675 Homo sapiens cDNA FU 14260 fis, clone PLACE1001 1 18, weakly similar to 140 LG:1082263.2:2000SEP08 gl3560887 5.00E-13 Homo sapiens EZFIT- related protein 1 mRNA, complete 141 LG:1048604.2:2000SEP08 gl4249843 6.00E-67 Homo sapiens. Similar to hypothetical protein FU23233, clone MGC: 14876, 142 LG:1085254.3:2000SEP08 g 10437559 0 Homo sapiens cDNA: FU21457 fis, clone COL04705. 143 LG:1400606.2:2000SEP08 g 14042549 9.00E-54 Homo sapiens cDNA FU 14779 fis, clone NT2RP4000398, moderately similar 144 LG:1090358.2:2000SEP08 g 10047182 6.00E-30 Homo sapiens mRNA for KIAA 1559 protein, partial eds. 145 LG:1079064.2:2000SEP08 g 10434649 0 Homo sapiens cDNA FU 12895 fis, clone NT2RP2004187, weakly similar to 146 LG:1076866.1.2000SEP08 g 10436460 Homo sapiens cDNA FU 14087 fis, clone MAMMA1000183, weakly similar to 147 LG:969359.1 :2000SEP08 g 13279004 1.00E-120 Homo sapiens, ferritin, light polypeptide, clone MGC: 10465, mRNA, 148 LG:366783.1 :2000SEP08 g9651703 Homo sapiens carboxypeptidase B precursor (CPAH) mRNA, complete 149 LG:332176.3:2000SEP08 g 13365900 Macaca fascicularis brain cDNA clone:QflA- TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 150 LG:994938.1 :2000SEP08 g7023331 1.00E-76 Homo sapiens cDNA FU 10961 fis, clone PLACE 1000588, highly similar to INTERFERON- 151 LG:982800.1 :2000SEP08 g 12053280 0 Homo sapiens mRNA; cDNA DKFZp434J037 (from clone DKFZp434J037); 152 LG:977850.7:2000SEP08 g 10436959 5.00E-64 Homo sapiens cDNA: FU20984 fis, clone CAE00871. 153 LG:234748.2:2000SEP08 g 13182754 0 Homo sapiens HPHRP mRNA, 154 LG:306284.1 :2000SEP08 g 14043648 0 Homo sapiens, clone MGC: 14161, mRNA, complete 155 LI:333170.3:2000SEP08 gl 2314083 1.00E-93 (fl) (Homo sapiens) dJ1007G 16.5 (novel high-mobility group (nonhistone chromosomal) 156 LI:336685.2:2000SEP08 gl 2697317 0 Homo sapiens partial mRNA for 157 LI:279013.5:2000SEP08 g 12840673 3.00E-55 0 (Mus musculus) 158 LI: 1037075.1 :2000SEP08 gl 1342540 0 Homo sapiens mRNA for putative white family ATP- binding cassette transporter (ABCG4 159 LI: 1073403.1 :2000SEP08 gl 2804680 9.00E-63 Homo sapiens, SI 00 calcium- binding protein, beta (neural), clone MGC: 1323, 160 LI: 1075296.1 :2000SEP08 g 12803084 1.00E-112 Homo sapiens, mitochondrial ribosomal protein LI 2, clone MGC:8610, mRNA, 161 LI: 1085501.1 :2000SEP08 gl2653784 1.00E-140 Homo sapiens, clone IMAGE:3349601, 162 U:1086181.1 :2000SEP08 g3043444 1.00E-146 Homo sapiens mRNA for EDF-1 163 U: 1164493.1 :2000SEP08 g 13436439 0 Homo sapiens, clone MGC4400, mRNA, complete TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 164 U: 1175097.1 :2000SEP08 g 13937908 4.00E-45 Homo sapiens. Similar to KIAA0961 protein, clone MGC: 12515, mRNA, 165 LI: 1092948.1.2000SEP08 g 12804414 2.00E-49 Homo sapiens. Similar to hypothetical protein FU 10891, clone MGC925, 166 LI:380378.2:2000SEP08 g8655612 3.00E-79 Homo sapiens mRNA; cDNA DKFZp76201415 (from clone 167 LI : 1029674.1 :2000SEP08 g9651088 4.00E-07 Macaca fascicularis brain 168 Ll:2048601.3:2000SEP08 g 10434880 1.00E-106 Homo sapiens cDNA FU 13048 fis, clone NT2RP3001399, weakly similar to 169 LI: 1186208.1 :2000SEP08 g 12052731 1.00E-175 Homo sapiens mRNA; cDNA DKFZp761G18121 (from clone DKFZp761G18121); 170 LI:1 170753.1 :2000SEP08 gl4249995 l .OOE-101 Homo sapiens, clone MGC: 12518, mRNA, complete 171 LI:1 180908.1 :2000SEP08 g 14042849 0 Homo sapiens cDNA FU 14959 fis, clone PLΛCE4000156, moderately similar 172 LI:1 182900.2:2000SEP08 g 10047304 Homo sapiens mRNA for KIAA1615 protein, partial eds. 173 LI: 1 169548.2:2000SEP08 g 1 017832 Homo sapiens mRNA for KIAA 1808 protein, partial eds. 174 LI: 1039974.1 :2000SEP08 g 13366083 Homo sapiens MARKL1 mRNA for MAP/microtubule affinity-regulating kinase like 1, 175 U:1175765.2:2000SEP08 gl3752753 5.00E-16 Homo sapiens zinc finger l l l l mRNA, complete eds. 176 LI:313948.1 :2000SEP08 g9651098 0 Macaca fascicularis brain TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 177 LI:335923.2:2000SEP08 gl 1990770 3.00E-73 (fl) (Homo sapiens) bA534G20.1.1 (novel protein similar to Lysozyme C-l (1,4-beta-N- acylmuramidase C, 178 LI:345884.1:2000SEP08 gl3591713 0 Homo sapiens immunoglobulin receptor translocation associated protein 2c (IRTA2) mRNA, 179 U:417127.1:2000SEP08 g12652726 1.00E-66 Homo sapiens, clone IMAGE:3352566, 180 Ll:451710.1 :2000SEP08 g13899057 l .OOE-όl (fl)(Mercurialis annua) ribosomal 181 U:406882.2:2000SEP08 g7019948 2.00E-57 Homo sapiens cDNA FU20081 fis, clone COL03242. 182 LI:728223.1:2000SEP08 g2624328 2.00E-44 (fl)(Oryza sativa) 183 U:289783.19:2000SEP08 gl2654714 0 Homo sapiens, Similar to glucose regulated protein, 58 kDa, clone 184 U:235255.8:2000SEP08 gl2597311 0 Homo sapiens clone IMAGE:72154 tRNA-guanine transglycosylase (TGT) mRNA, 185 LI:237693.5:2000SEP08 g12406772 4.00E-52 (fl) (Homo sapiens) unnamed protein 186 LI:433670.3:2000SEP08 gl4133250 0 Homo sapiens mRNA for KIAA 1479 protein, partial eds. 187 LI:202943.4:2000SEP08 g12060829 0 Homo sapiens serologically defined breast cancer antigen NY- BR-38 mRNA, 188 LI:068682.1 :2000SEP08 g13540325 0 Homo sapiens serine/threonine kinase FKSG82 (FKSG82) mRNA, 189 U:203301.3:2000SEP08 g10047160 0 Homo sapiens mRNA for KIAA1548 protein, partial eds. 190 LI:020726.3:2000SEP08 g12834087 1.OOE-157 0 (Mus musculus) TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 191 LI:027209.1:2000SEP08 g13159480 1.00E-127 (fl) (Homo sapiens) Translation may initiate at the ATG codon at nucleotides 40-42 192 U:108819.1:2000SEP08 gl2052773 0 Homo sapiens mRNA; cDNA DKFZp564B052 (from clone DKFZp564B052); 193 LI:021759.1 :2000SEP08 gl2006103 0 Homo sapiens IRA1 mRNA, complete eds, alternatively 1 4 LI:1165967.1 :2000SEP08 g13529103 1.00E- 172 Homo sapiens, ribosomal protein S27a, clone MGC: 12414, mRNA, 195 LI:1166315.1 :2000SEP08 g12653800 l.OOE-llό Homo sapiens, peptidylprolyl isomerase A (cyclophilin A), clone MGC:2351, 196 LI:204626.1:2000SEP08 g12844770 1.00E-138 0 (Mus musculus) 197 Ll:801140.1 :2000SEP08 gl2804322 0 Homo sapiens, clone MGC:4054, mRNA, complete 198 LI:286639.1:2000SEP08 gl3938318 0 Homo sapiens, clone MGC: 15664, mRNA, complete 199 LI:288905.4:2000SEP08 g12698056 0 Homo sapiens mRNA for KIAA 1756 protein, partial eds. 200 LI:332161.1:2000SEP08 g14388335 2.00E-62 Macaca fascicularis brain cDNA clone:QflA- 201 LI:184867.1:2000SEP08 g7209586 4.00E-47 (fl) (Rattus norvegicus) DA41 202 LI:229932.4:2000SEP08 g10438187 0 Homo sapiens CDNA: FU21963 fis, clone HEP05583. 203 U:l 189932.1 :2000SEP08 gl2483887 0 Homo sapiens solute carrier 19A3 mRNA, complete 204 LI:1076689.1 :2000SEP08 g12804758 6.00E-20 Homo sapiens, ribonuclease 6 precursor, clone MGC:3554, mRNA, 205 LI:415181.2:2000SEP08 gl 1762100 0 (fl) (Zea mays) myo- inositol 1- TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 206 LI:296358.1 :2000SEP08 g 12053148 0 Homo sapiens mRNA; cDNA DKFZp434G2226 (from clone DKFZp434G2226); 207 LI:205186.3:2000SEP08 g567232 4.00E-17 (fl) (Mus musculus) proline-rich protein 208 LI:220537.2:2000SEP08 g 13365896 0 Macaca fascicularis brain cDNA clone:QflA- 209 LI:248364.2:2000SEP08 g 12847599 0 0 (Mus musculus) 210 LI:2048338.1 :2000SEP08 g 12848905 3.00E-78 0(Mus musculus) 211 LI:1 185203.8:2000SEP08 gl 1231084 3.00E-85 Macaca fascicularis brain 212 U:021770.3:2000SEP08 g5931541 2.00E-45 Homo sapiens genomic DNA, chromosome 22ql l .2, BCRL2 213 U: 1 185841.1 :2000SEP08 g 14269501 0 Homo sapiens unconventional myosin IG valine form (MYOlG) mRNA, MYOI G-V 214 LI: 1181710.1 :2000SEP08 g7959206 2.00E-49 Homo sapiens mRNA for KIAA1473 protein, partial eds. 215 U:2048959.1 :2000SEP08 g5817101 1.00E-16 Homo sapiens mRNA; cDNA DKFZp434G1621 (from clone 216 LI:798494.1 :2000SEP08 gl0047182 2.00E-23 Homo sapiens mRNA for KIAA1559 protein, partial eds. 217 U:2049223.1 :2000SEP08 g7959206 2.00E-43 Homo sapiens mRNA for KIAA1473 protein, partial eds. 218 LI: 1177833.1 :2000SEP08 g 12052982 00 Homo sapiens mRNA; cDNA DKFZp434ll610 (from clone DKFZp434ll610); 219 U:2049267.1 :2000SEP08 g515786 6.00E-61 H.sapiens (MAR7) chromosome 19 DNA, 302bp. 220 LI: 1165939.1 :2000SEP08 g7020753 9.00E- 13 Homo sapiens cDNA FU20562 fis, clone KAT1 1992. 221 LI:1170958.1 :2000SEP08 g5262556 1.OOE-14 Homo sapiens mRNA; cDNA DKFZp569D2231 (from clone DKFZp569D2231); TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 222 LI: 1089827.1.2000SEP08 g 14042292 0 Homo sapiens cDNA FU 14636 fis, clone NT2RP2001233, weakly similar to 223 LI:7921 12.1 :2000SEP08 g 10437945 4.00E-61 Homo sapiens cDNA: FU21781 fis, clone HEP00223. 224 U:282219.2:2000SEP08 g 12656630 7.00E-63 Homo sapiens Kruppel-like zinc finger protein GLIS2 mRNA, complete 225 LI: 1088010.2:2000SEP08 gl3623632 00 Homo sapiens, clone MGC: 13105, mRNA, complete 226 LI: 1 165276.1 :2000SEP08 g6807586 1.OOE-106 Novel human gene mapping to chomosome 1. 227 LI: 1 169524.2:2000SEP08 g 10047182 5.00E-30 Homo sapiens mRNA for KIAA1559 protein, partial eds. 228 LI: 1 180255.1 :2000SEP08 g 14017870 0 Homo sapiens mRNA for KIAA1827 protein, partial eds. 229 LI: 1091903.1 :2000SEP08 g 14042372 2.00E-49 Homo sapiens cDNA FU 14686 fis, clone NT2RP2004961, moderately similar to Rattus norvegicus KRAB/zinc finger 230 LI: 1 169219.1 :2000SEP08 g 13937998 0 Homo sapiens, Similar to DNA- binding protein, clone MGC: 14780, 231 LI:2050313.1 :2000SEP08 g 12862319 0 Homo sapiens mRNA for WDC 146, 232 U:209351.3:2000SEP08 g 14042794 0 Homo sapiens cDNA FU 14923 fis, clone PI-ACE 1008244, weakly similar to VEGETATIBLE 233 U : 1 19900.1 :2000SEP08 g 14042821 2.00E-66 Homo sapiens cDNA FU 14939 fis, clone PLACE 1010702, moderately similar 234 Ll:2052274.1 :2000SEP08 g8698839 4.00E-07 Homo sapiens genomic DNA, chromosome 8q23, TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 235 U:1075502.1 :2000SEP08 gl3960141 1.OOE-1 14 Homo sapiens, uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'- decarboxylase), 236 LI:813697.1 :2000SEP08 g7020744 6.00E-59 Homo sapiens cDNA FU20557 fis, clone KAT 1 1869. 237 LI:814261.1 :2000SEP08 g7023331 1.00E-76 Homo sapiens cDNA FU 10961 fis, clone PLACE 1000588, highly similar to INTERFERON- 238 U:775334.1 :2000SEP08 g4589587 3.00E-23 Homo sapiens mRNA for KIAA0972 protein, complete 239 LI:1180325.1 :2000SEP08 gl0438159 0 Homo sapiens cDNA: FU21941 fis, clone HEP04524. 240 LI:1 183147.3:2000SEP08 gl0440084 0 Homo sapiens cDNA: FU23407 fis, clone HEP19601. 241 LI:1 175373.3:2000SEP08 g7243242 5.00E-51 Homo sapiens mRNA for KIAA 1431 protein, partial eds. 242 U:813757.1 :2000SEP08 g4589587 1.00E-31 Homo sapiens mRNA for KIAA0972 protein, complete 243 U:1 182979.2:2000SEP08 g 14042292 2.00E-87 Homo sapiens cDNA FU 14636 fis, clone NT2RP2001233, weakly similar to 244 LI:1 177823.2:2000SEP08 gl2052982 0 Homo sapiens mRNA; cDNA DKFZp434ll610 (from clone DKFZp434ll610); 245 LI : 1 174279.1 :2000SEP08 g 10047182 1.00E-27 Homo sapiens mRNA for KIAA1559 protein, partial eds. 246 LI : 1 17841 1.1 :2000SEP08 g 14042843 0 Homo sapiens cDNA FU 14954 fis, clone PI.ACE3000169, weakly similar to TABLE 2 SEQ ID NO: Template ID Gl Number Probability Score Annotation 247 U: 1 182739.1.2000SEP08 g!2655164 8.00E-31 Homo sapiens, zinc finger protein 256, clone MGC: 1413, mRNA, complete 248 U:234937.4:2000SEP08 g12804418 Homo sapiens, clone MGC: 1 136, mRNA, complete 249 LI:1170660.1 :2000SEP08 g14388419 Macaca fascicularis brain cDNA clone:QmoA- 250 LI:1144409.1 :2000SEP08 g12053280 Homo sapiens mRNA; cDNA DKFZp434J037 (from clone DKFZp434J037); 251 U:246290.10:2000SEP08 gl0438695 Homo sapiens cDNA: FU22347 fis, clone HRC06188. 252 Ll:280034.1 :2000SEP08 g 12847023 1.OOE-132 0 (Mus musculus) TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 1 LG:150318.1:2000SEP08 11 79 forward 2 zf-C2H2 Zinc finger, C2H2 type 2.00E-06 2 LG:022529.1 :2000SEP08 426 701 forward 3 C2 C2 domain 3.30E-06 3 LG:352559.1 :2000SEP08 125 313 forward 2 KRAB KRAB box 1.60E-41 4 LG:175223.1 :2000SEP08 210 431 forward 3 CSD 'Cold-shock' DNA-binding domain 1.40E-18 5 LG:476989.1 :2000SEP08 149 223 forward 2 zf-C3HC4 Zinc finger, C3HC4 type (RING finger) 3.00E-10 6 LG:253268.7:2000SEP08 21 1 435 forward 1 rrm RNA recognition motif, (a.k.a. RRM, 3.50E-16 RBD, or RNP domain) 7 LG:401322.1 :2000SEP08 156 341 forward 3 tubulin Tubulin/FtsZ family 7.10E-20 7 LG:401322.1 :2000SEP08 371 478 forward 2 tubulin Tubulin/FtsZ family 2.50E-06 8 LG:1328436.1 :2000SEP08 134 322 forward 2 KRAB KRAB box 1.70E-42 9 LG;475404.1 :2000SEP08 176 328 forward 2 KRAB KRAB box 1.10E-15 10 LG: 1384132.1 :2000SEP08 157 225 forward 1 zf-C2H2 Zinc finger, C2H2 type 9.00E-04 1 1 LG:410804.18:2000SEP08 133 243 forward 1 pkinase Protein kinase domain 7.90E-04 12 LG: 1082306.1 :2000SEP08 199 378 forward 1 KRAB KRAB box 4.90E-20 12 LG: 1082306.1 :2000SEP08 559 627 forward 1 zf-C2H2 Zinc finger, C2H2 type 9.60E-05 13 LG:233814.4:2000SEP08 624 947 forward 3 mito_carr Mitochondrial carrier protein 2.50E-04 14 LG:977478.5:2000SEP08 351 449 forward 3 ank Ank repeat 1.10E-08 15 LG:025931.1 :2000SEP08 660 728 forward 3 zf-C2H2 Zinc finger, C2H2 type 4.50E-06 15 LG:025931.1 :2000SEP08 29 97 forward 2 zf-C2H2 Zinc finger, C2H2 type 7.20E-06 16 LG:885368.1 :2000SEP08 133 462 forward 1 Ribosomal_S8 Ribosomal protein S8 7.50E-48 17 LG:1054900.1 :2000SEP08 78 218 forward 3 KRAB KRAB box 2.30E-17 18 LG:995186.2:2000SEP08 151 357 forward 1 KRAB KRAB box 1.10E-04 19 LG:435048.23:2000SEP08 2 457 forward 2 Peptidase_M17 Cytosol aminopeptidase family, 5.30E-09 catalytic domain 20 LG:954859.1 :2000SEP08 245 565 forward 2 Ribosomal_L7Ae Ribosomal protein 7.80E-17 L7Ae/L30e/S12e/Gadd45 family 21 LG:364370.1 :2000SEP08 42 578 forward 3 Ribosomal_L13e Ribosomal protein L13e 2.30E-137 22 LG:1098789.1 :2000SEP08 45 131 forward 3 efhand EF hand 8.70E-05 23 LG:201540.2:2000SEP08 479 604 forward 2 zf-B_box B-box zinc finger. 9.60E-1 23 LG:201540.2:2000SEP08 254 385 forward 2 zf-C3HC4 Zinc finger, C3HC4 type (RING finger) 4.80E-13 24 LG:1077357.1 :2000SEP08 94 282 forward 1 KRAB KRAB box 4.80E-31 25 LG:1048846.4:2000SEP08 60 245 forward 3 KRAB KRAB box 7.10E-39 TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 26 LG:336685.1 :2000SEP08 945 1 121 forward 3 homeobox Homeobox domain 3.10E-1 1 27 LG: 1076253.1.2D00SEP08 6 188 forward 3 KRAB KRAB box 4.10E-14 27 LG:1076253.1.2000SEP08 939 1007 forward 3 zf-C2H2 Zinc finger, C2H2 type 9.30E-06 28 LG:1400601.2:2000SEP08 38 106 forward 2 zf-C2H2 Zinc finger, C2H2 type 1.50E-05 29 LG:1079092.3:2000SEP08 314 382 forward 2 zf-C2H2 Zinc finger, C2H2 type 8.80E-06 30 LG:1086064.1.2000SEP08 128 316 forward 2 KRAB KRAB box 2.00E-34 31 LG: 1400608.1 :2000SEP08 138 326 forward 3 KRAB KRAB box 1.30E-40 32 LG:399275.5:2000SEP08 328 645 forward 1 BTB BTB/POZ domain 4.10E-18 33 LG:293943.1 :2000SEP08 265 327 forward 1 IQ IQ calmodulin-binding motif 5.10E-04 34 LG:345884.1 :2000SEP08 203 355 forward 2 '9 Immunoglobulin domain 7.40E-04 35 LG:400967.1 :2000SEP08 109 300 forward 1 KRAB KRAB box 1.50E-35 36 LG:024556.ό:2000SEP08 526 774 forward 1 mito_carr Mitochondrial carrier protein 2.90E-19 37 LG:081 189.3:2000SEP08 362 475 forward 2 EGF EGF-like domain 3.80E-06 38 LG:018258.1 :2000SEP08 174 605 forward 3 Nitroreductase Nitroreductase family 9.00E-05 « 0_0. 3<? LG:450399.3:2000SEP08 81 446 forward 3 Ribosomal_L14 Ribosomal protein L14p/L23e 1.20E-53 oo 40 LG:451 122.1 :2000SEP08 49 303 forward 1 ACBP Acyl CoA binding protein 1.70E-51 41 LG:451682.1 :2000SEP08 1 17 560 forward 3 proteasome Proteasome A-type and B-type 4.40E-59 42 LG:238631.4:2000SEP08 100 453 forward 1 KE2 KE2 family protein 3.80E-38 43 LG:236654, 1 :2000SEP08 810 878 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.20E-04 43 LG:236654.1 :2000SEP08 434 502 forward 2 zf-C2H2 Zinc finger, C2H2 type 6.60E-04 44 LG:332655.1 :2000SEP08 415 513 forward 1 ank Ank repeat 3.10E-10 45 LG:217396.2:2000SEP08 679 882 forward 1 ELM2 ELM2 domain 5.00E-14 45 LG:217396.2:2000SEP08 994 1 134 forward 1 myb_DNA-binding Myb-like DNA-binding domain 2.00E-1 1 46 LG:090574.1 :2000SEP08 33 245 forward 3 carb_anhydrase Eukaryotic-type carbonic anhydrase 3.10E-31 47 LG:202943.1 :2000SEP08 199 360 forward 1 sushi Sushi domain (SCR repeat) 3.80E-18 48 LG:236928.1 :2000SEP08 259 1101 forward 1 GNS1_SUR4 GNS1 /SUR4 family 9.80E-09 49 LG:215169.2:2000SEP08 89 208 forward 2 ldl_recept_a Low-density lipoprotein receptor 1.00E-12 domain class A 50 LG:410726.1 :2000SEP08 724 912 forward 1 KRAB KRAB box 2.10E-17 50 LG:410726.1 :2000SEP08 352 636 forward 1 SCAN SCAN domain 8.90E-55 51 LG:234372.2:2000SEP08 557 862 forward 2 PH PH domain 3.00E-09 51 LG:234372.2:2000SEP08 950 1408 forward 2 RhoGAP RhoGAP domain 3.30E-39 TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 51 LG:234372.2:2000SEP08 1952 21 19 forward 2 SH3 SH3 domain 4.60E-1 1 52 LG:022629.1 :2000SEP08 261 410 forward 3 zf-C3HC4 Zinc finger, C3HC4 type (RING finger) 2.00E-07 53 LG:068682.1 :2000SEP08 176 883 forward 2 pkinase Protein kinase domain 1.70E-65 54 LG:222335.1 :2000SEP08 7 732 forward 1 DUF71 Domain of unknown function DUF71 6.70E-83 55 LG:331342.1 :2000SEP08 558 1076 forward 3 arf ADP-ribosylation factor family 1.20E-04 55 LG:331342.1 :2000SEP08 588 1 154 forward 3 ras Ras family 2.60E-79 56 LG:021770, 1 :2000SEP08 228 1 199 forward 3 adh_zinc Zinc-binding dehydrogenases 7.80E-20 57 LG:181607,9:2000SEP08 161 604 forward 2 Josephin Josephin 5.00E-50 58 LG:1042768.1 :2000SEP08 42 443 forward 3 Tim 17 Mitochondrial import inner membrane 1.40E-82 translocase subunit Tim 17 59 LG;282729.1 :2000SEP08 61 192 forward 1 SJ00 S-100/ICaBP type calcium binding 1.10E-12 domain 60 LG:998305.3:2000SEP08 266 364 forward 2 ank Ank repeat 2.10E-07 61 LG:1 135213.1 :2000SEP08 340 531 forward 1 T-box T-box 8.80E-27 62 LG:267762.1 :2000SEP08 64 1 125 forward 1 A_deaminase Adenosine/AMP deaminase 7.80E-20 63 LG:120744.1 :2000SEP08 301 813 forward 1 vwa von Willebrand factor type A domain 1.90E-52 64 LG:403409.1 :2000SEP08 1458 1652 forward 3 FHA FHA domain 3.00E-04 64 LG:403409.1 :2000SEP08 78 1 193 forward 3 kinesin Kinesin motor domain 6.80E-172 65 LG:226874.3:2000SEP08 1 18 291 forward 1 UM UM domain 8.40E-13 66 LG:1045521.4:2000SEP08 160 1464 forward 1 aminotran Aminotransferase class-l 2.00E-10 67 LG:275876.1 :2000SEP08 508 831 forward 1 CH Calponin homology (CH) domain 2.40E-26 68 LG:475127.7:2000SEP08 169 498 forward 1 GTP_EFU Elongation factor Tu family 2.20E-46 69 LG:157263.1 :2000SEP08 163 1314 forward 1 MCT Monocarboxylate transporter 6.10E-31 70 LG:247382.7:2000SEP08 1105 1353 forward 1 PDZ PDZ domain (Also known as DHR or 4.20E-07 GLGF). 70 LG:247382.7:2000SEP08 487 684 forward 1 SAM SAM domain (Sterile alpha motif) 1.20E-1 1 71 LG:197367.5:2000SEP08 50 472 forward 2 Pept_tRNA_hydro Peptidyl-tRNA hydrolase 8.90E-05 72 LG:218090.5:2000SEP08 179 295 forward 2 zf-MYND MYND finger 3.00E-10 73 LG:216612.4:2000SEP08 138 1274 forward 3 Cation_efflux Cation efflux family 8.90E-63 74 LG:197614.1 :2000SEP08 1699 3048 forward 1 OxysteroLBP Oxysterol-binding protein 4.10E-31 74 LG:1 7614.1 :2000SEP08 886 1 164 forward 1 PH PH domain 1.20E-14 75 LG:378428.1 :2000SEP08 621 920 forward 3 PH PH domain 2.00E-06 TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 76 LG:286639.1 :2000SEP08 1294 1713 forward 1 actin Actin 9.10E-64 76 LG:286639.1 :2000SEP08 630 1319 forward 3 actin Actin 1.70E-62 77 LG:389870.1 :2000SEP08 131 640 forward 2 ras Ras family 3.40E-37 78 LG:1387485.6:2000SEP08 227 709 forward 2 adh_short short chain dehydrogenase 1.1 OE-25 79 LG:230151.1 :2000SEP08 631 1602 forward 1 El_dehydrog Dehydrogenase El component 1.10E-09 80 LG:215158.5:2000SEP08 1243 1377 forward 1 zf-ANl AN 1 -like Zinc finger 9.10E-04 81 LG:235840.1 :2000SEP08 1241 1537 forward 2 K etra K+ channel tetramerisation domain 5.60E-22 82 LG:350272.1 :2000SEP08 1424 1780 forward 2 SPRY SPRY domain 2.10E-10 82 LG:350272.1 :2000SEP08 557 682 forward 2 Z.-C3HC4 Zinc finger, C3HC4 type (RING finger) 5.30E-1 1 83 LG:232190.1 :2000SEP08 497 691 forward 2 zf-DHHC DHHC zinc finger domain 2.30E-38 84 LG: 1068127.1 :2000SEP08 158 307 forward 2 KRAB KRAB box 3.00E-12 85 LG:408751.3:2000SEP08 194 1204 forward 2 Dihydroorotase Dihydroorotase-like 1.20E-12 85 LG:408751.3:2000SEP08 456 1355 forward 3 Dihydroorotase Dihydroorotase-like 6.60E-08 86 LG:1078933.1 :2000SEP08 373 441 forward 1 zf-C2H2 Zinc finger, C2H2 type 1.20E-07 86 LG:1078933.1 :2000SEP08 689 775 forward 2 zf-C2H2 Zinc finger, C2H2 type 1.00E-03 87 LG:958731.1 :2000SEP08 153 707 forward 3 adh_short short chain dehydrogenase 2.40E-39 88 LG:024125.5:2000SEP08 132 635 forward 3 FAA_hydrolase Fumarylacetoacetate (FAA) hydrolase 1.20E-83 family 89 LG:373637.3:2000SEP08 61 255 forward 1 DnaJ DnaJ domain 7.40E-33 90 LG:1053229.1 :2000SEP08 514 582 forward 1 zf-C2H2 Zinc finger, C2H2 type 2.50E-08 91 LG:248364.1 :2000SEP08 253 594 forward 1 BTB BTB/POZ domain 3.60E-04 91 LG:248364.1 :2000SEP08 1544 1612 forward 2 zf-C2H2 Zinc finger, C2H2 type 7.10E-06 92 LG:477130.1 :2000SEP08 174 554 forward 3 Ribosomal_L13 Ribosomal protein LI 3 3.60E-37 93 LG:1 13786.17:2000SEP08 134 376 forward 2 PDZ PDZ domain (Also known as DHR or 8.10E-15 GLGF). 94 LG:347635.1 :2000SEP08 315 410 forward 3 EGF EGF-like domain 6.70E-09 94 LG:347635.1 :2000SEP08 605 709 forward 2 EGF EGF-like domain 1.10E-04 94 LG:347635.1 :2000SEP08 1057 1 152 forward 1 EGF EGF-like domain 1.20E-04 95 LG:242966.4:2000SEP08 7 918 forward 1 aldedh Aldehyde dehydrogenase family 1.10E-05 95 LG:242966.4:2000SEP08 1031 1993 forward 2 aldedh Aldehyde dehydrogenase family 2.20E-05 96 LG:217814.1 :2000SEP08 1167 1265 forward 3 ank Ank repeat 6.60E-08 TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 97 LG:476452.1 :2000SEP08 210 581 forward 3 Glyoxalase Glyoxalase/Bleomycin resistance 8.10E-39 protein/Dioxygenase superfamily 98 LG: 1100657.1.2000SEP08 151 384 forward 1 hormoneδ Neurohypophysial hormones, C- 8.60E-47 terminal Domain 99 LG:1 132418.2:2000SEP08 109 393 forward 1 proteasome Proteasome A-type and B-type 1.10E-14 100 LG:1098570.1 :2000SEP08 129 572 forward 3 NDK Nucleoside diphosphate kinases 3.70E-1 17 101 LG:1097987.1 :2000SEP08 747 908 forward 3 Ribosomal_L23 Ribosomal protein L23 5.80E-14 102 LG:337818.2:2000SEP08 136 1518 forward 1 p450 Cytochrome P450 6.30E-175 103 LG: 1040582.1 :2000SEP08 266 556 forward 2 aldo_ket_red Aldo/keto reductase family 1.30E-47 103 LG: 1040582.1 :2000SEP08 546 635 forward 3 aldo_ket_red Aldo/keto reductase family 7.60E-06 104 LG: 1099122.1 :2000SEP08 84 248 forward 3 G-gamma GGL domain 4.90E-31 105 LG: 1327449.1.2000SEP08 461 526 forward 2 Ribosomal_S8 Ribosomal protein S8 4.80E-07 105 LG: 1327449.1.2000SEP08 246 359 forward 3 Ribosomal_S8 Ribosomal protein S8 3.00E-06 106 LG:227933.5:2000SEP08 523 1455 forward 1 AMP-binding AMP-binding enzyme 7.20E-05 107 LG:1043709.2:2000SEP08 457 723 forward 1 oxidored_q6 NADH ubiquinone oxidoreductase, 20 8.40E-08 Kd subunit 108 LG: 1099871.1 :2000SEP08 34 41 1 forward 1 histone Core histone H2A/H2B/H3/H4 4.50E-47 109 LG:1399139.4:2000SEP08 117 233 forward 3 CAP_GLY CAP-Gly domain 4.30E-10 1 10 LG:236386.1 :2000SEP08 1383 1712 forward 3 PX PX domain 1.90E-13 111 LG:1015157.1 :2000SEP08 1 15 552 forward 1 Glyoxalase Glyoxalase/Bleomycin resistance 6.00E-38 protein/Dioxygenase superfamily 112 LG: 1065433.1 :2000SEP08 264 449 forward 3 KRAB KRAB box 1.30E-38 1 13 LG:236992.4:2000SEP08 286 465 forward 1 Sema Sema domain 2.70E-21 113 LG:236992.4:2000SEP08 209 292 forward 2 Sema Sema domain 3.60E-06 114 LG: 1071 124.1 :2000SEP08 469 630 forward 1 KRAB KRAB box 1.20E-16 1 15 LG:206425.2:2000SEP08 109 519 forward 1 GBP Guanylate-binding protein, N-terminal 1.60E-100 domain 1 15 LG:206425.2:2000SEP08 491 916 forward 2 GBP Guanylate-binding protein, N-terminal 2.70E-70 domain 1 15 LG:206425.2:2000SEP08 1 164 1685 forward 3 GBP_C Guanylate-binding protein, C-terminal 3.50E-71 domain TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 1 15 LG:206425.2:2000SEP08 920 1201 forward 2 GBP_C Guanylate-binding protein, C-terminal 3.10E-63 domain 1 15 LG:206425.2:2000SEP08 1651 1773 forward 1 GBP_C Guanylate-binding protein, C-terminal 1.80E-04 domain 116 LG:885747.2:2000SEP08 372 569 forward 3 Ribosomal_L31e Ribosomal protein L31e 9.50E-16 117 LG: 1 140501.1 :2000SEP08 176 340 forward 2 ATP1G1_PLM_MAT8 ATP1G1/PLM/MAT8 family 9.30E-22 1 18 LG:001239.1 ;2000SEP08 1686 1850 forward 3 ig Immunoglobulin domain 2.50E-08 118 LG:001239.1 :2000SEP08 1391 1561 forward 2 ig Immunoglobulin domain 4.00E-08 119 LG:018980.1 :2000SEP08 395 502 forward 2 GTP_EFTU Elongation factor Tu family 3.20E-09 1 19 LG:018980.1 :2000SEP08 634 801 forward 1 GTP.EFU Elongation factor Tu family 3.50E-07 119 LG:018980.1 :2000SEP08 159 215 forward 3 GTP_EFTU Elongation factor Tu family 6.90E-07 120 LG:1083120.3:2000SEP08 117 266 forward 3 KRAB KRAB box 5.10E-22 121 LG:233258.3:2000SEP08 1797 2069 forward 3 cadherin Cadherin domain 3.90E-24 122 LG:999062.1 :2000SEP08 78 497 forward 3 Ribosomal_S19e Ribosomal protein S19e 2.10E-101 123 LG:88777ό.l :2000SEP08 101 625 forward 2 transport_prot Serum albumin family 3.30E-92 123 LG:887776.1 :2000SEP08 699 1 163 forward 3 transport_prot Serum albumin family 5.90E-41 124 LG: 1400301.2:2000SEP08 253 441 forward 1 KRAB KRAB box 2.10E-38 125 LG: 1329362.1 :2000SEP08 194 262 forward 2 zf-C2H2 Zinc finger, C2H2 type 3.90E-06 126 LG:1096498.1 :2000SEP08 17 358 forward 2 όOsjiboso al 60s Acidic ribosomal protein 1.70E-48 127 LG:1096337.1 :2000SEP08 512 637 forward 2 όOsjibosomal 60s Acidic ribosomal protein 4.10E-07 127 LG:1096337.1 :2000SEP08 619 738 forward 1 όOsjibosomal 60s Acidic ribosomal protein 1.50E-04 128 LG: 1400579.1 :2000SEP08 200 268 forward 2 zf-C2H2 Zinc finger, C2H2 type 7.80E-05 129 LG:1080091.1 :2000SEP08 151 318 forward 1 KRAB KRAB box 1.80E-25 130 LG:1082203.1 :2000SEP08 961 1029 forward 1 zf-C2H2 Zinc finger, C2H2 type 2.10E-08 131 LG: 1084051.1 :2000SEP08 195 263 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.80E-06 132 LG:1082393.1 :2000SEP08 237 425 forward 3 KRAB KRAB box 1.80E-36 132 LG:1082393.1 :2000SEP08 1251 1319 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.40E-06 133 LG: 1086183.1 :2000SEP08 308 478 forward 2 KRAB KRAB box 1.50E-15 133 LG: 1086183.1 :2000SEP08 833 901 forward 2 zf-C2H2 Zinc finger, C2H2 type 9.60E-07 134 LG:1090268.1 :2000SEP08 1167 1235 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.00E-07 135 LG:1400597.5:2000SEP08 63 131 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.20E-04 136 LG:1080307.2:2000SEP08 108 239 forward 3 KRAB KRAB box 3.60E-04 TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 137 LG:1400603.2:2000SEP08 299 490 forward 2 KRAB KRAB box 5.50E-41 137 LG:1400603.2:2000SEP08 929 997 forward 2 zf-C2H2 Zinc finger, C2H2 type 1.20E-04 138 LG:1052984.1 :2000SEP08 142 330 forward 1 KRAB KRAB box 3.70E-41 139 LG: 1091259.1.2000SEP08 555 623 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.20E-07 140 LG:1082263.2:2000SEP08 258 443 forward 3 KRAB KRAB box 2.50E-29 140 LG:1082263.2:2000SEP08 981 1049 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.70E-07 141 LG:1048604.2:2000SEP08 351 530 forward 3 KRAB KRAB box 3.50E-20 142 LG:1085254.3:2000SEP08 746 814 forward 2 zf-C2H2 Zinc finger, C2H2 type 3.10E-07 143 LG: 1400606.2:2000SEP08 244 432 forward 1 KRAB KRAB box 7.60E-41 143 LG: 1400606.2:2000SEP08 904 972 forward 1 zf-C2H2 Zinc finger, C2H2 type 1.80E-07 144 LG:1090358.2:2000SEP08 385 573 forward 1 KRAB KRAB box 1.30E-47 144 LG:1090358.2:2000SEP08 862 930 forward 1 Zf-C2H2 Zinc finger, C2H2 type 7.90E-07 145 LG:1079064.2:2000SEP08 325 612 forward 1 SCAN SCAN domain 3.00E-39 146 LG:1076866.1 :2000SEP08 203 391 forward 2 KRAB KRAB box 6.20E-39 1 46 LG:1076866.1 :2000SEP08 1868 1936 forward 2 zf-C2H2 Zinc finger, C2H2 type 5.20E-08 147 LG:969359.1 :2000SEP08 221 715 forward 2 ferritin Ferritin 3.10E-86 148 LG:366783.1 :2000SEP08 70 609 forward 1 Zn_carbOpept Zinc carboxypeptidase 8.80E-76 148 LG:366783.1 :2000SEP08 705 806 forward 3 Zn_carbOpept Zinc carboxypeptidase 2.20E-10 148 LG:366783.1 :2000SEP08 623 724 forward 2 Zn_carbOpept Zinc carboxypeptidase 1.80E-05 149 LG:332176.3:2000SEP08 5 1060 forward 2 Glyco_hydro_31 Glycosyl hydrolases family 31 2.40E-163 150 LG:994938.1 :2000SEP08 3 95 forward 3 GBP Guanylate-binding protein, N-terminal 4.20E-14 domain 151 LG:982800.1 :2000SEP08 16 243 forward 1 pkinase Protein kinase domain 1.30E-10 152 LG:977850.7:2000SEP08 7 102 forward 1 zf-DHHC DHHC zinc finger domain 1.30E-04 153 LG:234748.2:2000SEP08 6 149 forward 3 PTE Phosphotriesterase family 1.20E-19 154 LG:306284.1 :2000SEP08 197 613 forward 2 Band_41 FERM domain (Band 4.1 family) 2.00E-52 155 U:333170.3:2000SEP08 292 498 forward 1 HMG_box HMG (high mobility group) box 1.80E-22 156 LI:336685.2:2000SEP08 913 1092 forward 1 homeobox Homeobox domain 4.20E-15 157 U:279013.5:2000SEP08 393 500 forward 3 WD40 WD domain, G-beta repeat 2.70E-05 158 LI :1037075.1 :2000SEP08 322 666 forward 1 ABC ran ABC transporter 7.10E-04 158 LI: 1037075.1 :2000SEP08 328 375 forward 1 PRK Phosphoribulokinase / Uridine kinase 7.40E-04 family TABLE 3 SEQ ID NO Template ID Start Stop Frame Pfam Hit Pfam Description E-value 159 LI 107340312000SEP08 203 289 forward 2 efhand EF hand 5 50E-04 159 U 107340312000SEP08 56 187 forward 2 SJOO S-100/ICaBP type calcium binding 3 60E-23 domain 160 U 107529612000SEP08 337 543 forward 1 Rιbosomal_L12 Ribosomal protein L7/L12 C-terminal 540E-09 domain 161 LI 108550112000SEP08 561 776 forward 3 EF1 BD EF-1 guanine nucleotide exchange 1 20E-24 domain 162 LI 108618112000SEP08 305 469 forward 2 HTH_3 He x-turn-helix 1 20E-10 163 LI 116449312000SEP08 365 553 forward 2 KRAB KRAB box 8 10E-31 164 LI 117509712000SEP08 460 648 forward 1 KRAB KRAB box 7 60E-41 165 LI 109294812000SEP08 446 595 forward 2 KRAB KRAB box 280E-21 166 LI 38037822000SEP08 120 419 forward 3 mιto_carr Mitochondrial carrier protein 1 30E-25 167 LI 102967412000SEP08 360 431 forward 3 LRR Leucme Rich Repeat 900E-04 168 LI 204860132000SEP08 2 145 forward 2 >g Immunoglobulin domain 3 00E-05 169 LI 118620812000SEP08 161 349 forward 2 KRAB KRAB box 1 30E 40 -P- 170 LI 117075312000SEP08 130 318 forward 1 KRAB KRAB box 8 40E-42 171 LI 118090812000SEP08 509 577 forward 2 zf-C2H2 Zinc finger, C2H2 type 3 90E-06 171 LI 118090812000SEP08 340 408 forward 1 zf-C2H2 Zinc finger, C2H2 type 1 30E-04 172 Llll8290022000SEP08 346 414 forward 1 zf-C2H2 Zinc finger, C2H2 type 3 10E-07 173 LI 116954822000SEP08 393 500 forward 3 VHP Villin headpiece domain 7 10E-20 174 U 103997412000SEP08 191 742 forward 2 pkinase Protein kinase domain 1 30E-37 175 LI 117576522000SEP08 279 446 forward 3 KRAB KRAB box 520E-23 176 LI 31394812000SEP08 75 143 forward 3 zf-C2H2 Zinc finger, C2H2 type 2 20E 07 177 LI 33592322000SEP08 215 523 forward 2 lys C-type lysozyme/alpha-lactalbumm 1 60E-42 family 178 U 34588412000SEP08 208 360 forward 1 ig Immunoglobulin domain 7 40E-04 179 U 41712712000SEP08 359 529 forward 2 KRAB KRAB box 490E-22 180 U 45171012000SEP08 130 459 forward 1 Rιbosomal_L32e Ribosomal protein L32 4 80E-57 181 LI 40688222000SEP08 247 408 forward 1 Kelch Kelch motif 4 20E-1 1 181 U 406882.22000SEP08 656 793 forward 2 Kelch Kelch motif 8 90E-09 182 U 72822312000SEP08 158 373 forward 2 rrm RNA recognition motif (a k a RRM, 1 20E-28 RBD, or RNP domain) ,_.!-__ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 183 11289783.19:2000SEP08 821 1003 forward 2 thiored Thioredoxin 1.70E-20 183 LI:289783.19:2000SEP08 747 800 forward 3 thiored Thioredoxin 5.10E-05 184 U:235255.8:2000SEP08 419 919 forward 2 TGT Queuine tRNA-ribosyltransferase 2.10E-24 184 U:235255.8:2000SEP08 747 1346 forward 3 TGT Queuine tRNA-ribosyltransferase 7.00E-15 185 LI:237693.5:2000SEP08 48 518 forward 3 abhydrolase_2 Phospholipase/Carboxylesterase 6.20E-07 186 U:433670.3:2000SEP08 404 682 forward 2 Sema Sema domain 3.80E-26 187 LI:202943.4:2000SEP08 1 19 223 forward 2 EGF EGF-like domain 1.60E-05 187 U:202943.4:2000SEP08 1304 1465 forward 2 sushi Sushi domain (SCR repeat) 3.80E-18 188 U:068682.1 :2000SEP08 169 876 forward 1 pkinase Protein kinase domain 1.70E-65 189 U:203301.3:2000SEP08 570 716 forward 3 Band_41 FERM domain (Band 4.1 family) 1.50E-20 189 U:203301.3:2000SEP08 365 577 forward 2 Band_41 FERM domain (Band 4.1 family) 6.30E-16 190 U:020726.3:2000SEP08 542 1915 forward 2 MCT Monocarboxylate transporter 1.80E-98 191 U:027209.1 :2000SEP08 379 987 forward 1 fibrinogen_C Fibrinogen beta and gamma chains, C- 7.80E-43 terminal globular domain 1 2 U:108819.1 :2000SEP08 316 828 forward 1 vwa von Willebrand factor type A domain 1.90E-52 1 3 U:021759.1 :2000SEP08 1 136 1246 forward 2 WD40 WD domain, G-beta repeat 1.70E-07 194 U: 1 165967.1 :2000SEP08 322 462 forward 1 Ribosomal_S27 Ribosomal protein S27a 1.50E-30 194 U: 1 165967.1 :2000SEP08 22 243 forward 1 ubiquitin Ubiquitin family 4.50E-42 195 LI: 1 166315.1 :2000SEP08 131 283 forward 2 projsomerase Cyclophilin type peptidyl-prolyl cis- 1.10E-26 trans isomerase 195 U:1 166315.1 :2000SEP08 280 423 forward 1 projsomerase Cyclophilin type peptidyl-prolyl cis- 5.50E-17 trans isomerase 195 U:l 166315.1 :2000SEP08 423 482 forward 3 projsomerase Cyclophilin type peptidyl-prolyl cis- 4.10E-06 trans isomerase 196 L1:204626.1 :2000SEP08 322 1212 forward 1 Syntaxin Syntaxin 8.60E-44 197 LI :801 140.1 :2000SEP08 516 584 forward 3 zf-C2H2 Zinc finger, C2H2 type 2.50E-08 198 U:286639.1 :2000SEP08 1295 1714 forward 2 actin Actin 9.10E-64 198 LI:286639.1 :2000SEP08 772 1296 forward 1 actin Actin 1.60E-44 198 U:286639.1 :2000SEP08 630 755 forward 3 actin Actin 1.10E-09 199 LI:288905.4:2000SEP08 285 602 forward 3 CH Calponin homology (CH) domain 5.30E-27 200 U:332161.1 :2000SEP08 75 710 forward 3 ras Ras family 2.00E-48 201 LI: 184867.1 :2000SEP08 365 478 forward 2 ubiquitin Ubiquitin family 1.40E-04 TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 202 U:229932.4:2000SEP08 58 969 forward 1 AMP-binding AMP-binding enzyme 3.00E-06 203 U: 1 189932.1 :2000SEP08 95 1441 forward 2 Folate_carrier Reduced folate carrier 5.80E-10 204 LI: 1076689.1 :2000SEP08 346 708 forward 1 ribonuclease_T2 Ribonuclease T2 family 6.50E-19 205 U:415181.2:2000SEP08 505 1584 forward 1 lnos-l-P_synth Myo-inosi tol-1 -phosphate synthase 2.30E-136 205 U:415181.2:2000SEP08 294 1220 forward 3 lnos-l-P_synth Myo-inositol-1 -phosphate synthase 3.40E-16 206 LI:296358.1 :2000SEP08 678 1061 forward 3 kinesin Kinesin motor domain 1.40E-46 206 U:29ό358.1 :2000SEP08 163 510 forward 1 kinesin Kinesin motor domain 6.80E-24 207 LI:205186.3:2000SEP08 476 982 forward 2 lactamase_B Metallo-beta-lactamase superfamily 3.70E-06 208 U:220537.2:2000SEP08 60 1574 forward 3 sugarjr Sugar (and other) transporter 6.40E-07 209 U:248364.2:2000SEP08 253 594 forward 1 BTB BTB/POZ domain 3.60E-04 209 U:248364.2:2000SEP08 1544 1612 forward 2 zf-C2H2 Zinc finger, C2H2 type 7.10E-06 210 U:2048338.1 :2000SEP08 261 410 forward 3 zf-C3HC4 Zinc finger, C3HC4 type (RING finger) 2.00E-07 21 1 LI:1 185203.8:2000SEP08 333 431 forward 3 ank Ank repeat 2.20E-07 212 LI:021770.3:2000SEP08 287 1 171 forward 2 adh_zinc Zinc-binding dehydrogenases 3.70E-08 213 LI: 1 185841.1 :2000SEP08 705 860 forward 3 myosinjiead Myosin head (motor domain) 1.80E-07 213 U:1 185841.1 :2000SEP08 992 1063 forward 2 myosin_head Myosin head (motor domain) 3.20E-04 214 U: 1 181710.1 :2000SEP08 62 130 forward 2 zf-C2H2 Zinc finger, C2H2 type 1.10E-05 215 LI:2048959.1 :2000SEP08 225 293 forward 3 zf-C2H2 Zinc finger, C2H2 type 4.10E-07 216 LI:798494.1 :2000SEP08 273 464 forward 3 KRAB KRAB box 2.00E-42 216 U:798494.1 :2000SEP08 675 743 forward 3 zf-C2H2 Zinc finger, C2H2 type 4.50E-05 216 U:798494.1 :2000SEP08 794 862 forward 2 zf-C2H2 Zinc finger, C2H2 type 6.80E-04 217 U:2049223.1 :2000SEP08 130 318 forward 1 KRAB KRAB box 2.10E-42 218 U:1 177833,1 :2000SEP08 78 218 forward 3 KRAB KRAB box 2.30E-17 218 LI: 1 177833.1 :2000SEP08 999 1067 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.70E-04 219 LI:2049267.1 :2000SEP08 78 227 forward 3 KRAB KRAB box 3.70E-22 220 U: 1 165939.1 :2000SEP08 247 315 forward 1 zf-C2H2 Zinc finger, C2H2 type 2.60E-06 221 U:1 170958.1 :2000SEP08 397 465 forward 1 zf-C2H2 Zinc finger, C2H2 type 3.20E-07 222 LI: 1089827.1 :2000SEP08 722 790 forward 2 Zf-C2H2 Zinc finger, C2H2 type 3.10E-07 222 LI: 1089827.1 :2000SEP08 105 173 forward 3 zf-C2H2 Zinc finger, C2H2 type 9.60E-07 222 LI: 1089827.1 :2000SEP08 433 501 forward 1 zf-C2H2 Zinc finger, C2H2 type 2.10E-06 223 LI:7921 12.1 :2000SEP08 200 268 forward 2 zf-C2H2 Zinc finger, C2H2 type 7.80E-05 224 U:282219.2:2000SEP08 129 197 forward 3 zf-C2H2 Zinc finger, C2H2 type 4.10E-05 TABLE 3 SEQ ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 225 LI: 1088010.2:2000SEP08 294 362 forward 3 zf-C2H2 Zinc finger, C2H2 type 5.80E-08 226 LI: 1 165276.1.2000SEP08 195 263 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.80E-06 227 LI:1 169524.2:2000SEP08 267 455 forward 3 KRAB KRAB box 2.70E-40 227 U:1 169524.2:2000SEP08 727 795 forward 1 zf-C2H2 Zinc finger, C2H2 type 7.90E-07 228 U: 1 180255.1 :2000SEP08 440 628 forward 2 KRAB KRAB box 2.30E-33 228 U: 1 180255.1 :2000SEP08 1027 1095 forward 1 zf-C2H2 Zinc finger, C2H2 type 2.50E-07 229 LI:1091903.1 :2000SEP08 182 370 forward 2 KRAB KRAB box 6.20E-39 230 LI:1 169219.1 :2000SEP08 142 330 forward 1 KRAB KRAB box 3.70E-41 231 LI:2050313.1 :2000SEP08 803 982 forward 2 Collagen Collagen triple helix repeat (20 copies) 9.50E-10 232 Ll:209351.3:2000SEP08 561 671 forward 3 WD40 WD domain, G-beta repeat 2.20E-06 232 U:209351 ,3:2000SEP08 313 423 forward 1 WD40 WD domain, G-beta repeat 1.00E-04 233 LI:119900.1 :2000SEP08 179 358 forward 2 KRAB KRAB box 1.50E-34 234 LI:2052274.1 :2000SEP08 193 1 197 forward 1 A_deaminase Adenosine/ AMP deaminase 4.00E-10 235 LI: 1075502.1 :2000SEP08 100 315 forward 1 OMPdecase Orotidine 5'-phosphate decarboxylase 6.30E-35 vo 235 LI: 1075502.1 :2000SEP08 305 451 forward 2 OMPdecase Orotidine 5'-phosphate decarboxylase 4.70E-26 -- , 235 LI: 1075502.1 :2000SEP08 426 806 forward 3 OMPdecase Orotidine 5'-phosphate decarboxylase 1.80E-12 236 LI:813697.1 :2000SEP08 753 821 forward 3 zf-C2H2 Zinc finger, C2H2 type 1.60E-07 237 U:814261.1 :2000SEP08 3 95 forward 3 GBP Guanylate-binding protein, N-terminal 4.20E-14 domain 238 LI:775334.1 :2000SEP08 1 12 180 forward 1 zf-C2H2 Zinc finger, C2H2 type 2.10E-08 239 LI:1 180325.1 :2000SEP08 495 563 forward 3 zf-C2H2 Zinc finger, C2H2 type 2.20E-07 240 LI:1 183147.3:2000SEP08 82 150 forward 1 zf-C2H2 Zinc finger, C2H2 type 1.20E-04 241 LI: 1 175373.3:2000SEP08 191 379 forward 2 KRAB KRAB box 6.80E-45 242 U:813757.1 :2000SEP08 268 453 forward 1 KRAB KRAB box 4.30E-38 243 LI:1 182979.2:2000SEP08 341 409 forward 2 zf-C2H2 Zinc finger, C2H2 type 3.60E-06 244 U: 1 177823.2:2000SEP08 1232 1372 forward 2 KRAB KRAB box 3.00E-15 245 LI : 1 174279.1 :2000SEP08 276 464 forward 3 KRAB KRAB box 1.40E-46 245 U:1 174279.1 :2000SEP08 753 821 forward 3 zf-C2H2 Zinc finger, C2H2 type 7.90E-07 246 Ll:l 178411.1 :2000SEP08 787 855 forward 1 zf-C2H2 Zinc finger, C2H2 type 1.20E-07 247 LI: 1 182739.1 :2000SEP08 582 650 forward 3 Zf-C2H2 Zinc finger, C2H2 type 6.70E-08 248 U:234937.4:2000SEP08 61 477 forward 1 DSPc Dual specificity phosphatase, catalytic 8.70E-29 domain TABLE 3 - ID NO: Template ID Start Stop Frame Pfam Hit Pfam Description E-value 249 LI: 1 170660.1 :2000SEP08 35 103 forward 2 zf-C2H2 Zinc finger, C2H2 type 8.70E-07 250 U: 1 144409.1.2000SEP08 16 243 forward 1 pkinase Protein kinase domain 1.30E-10 251 LI:246290.10:2000SEP08 256 453 forward 1 rrm RNA recognition motif, (a.k.a. RRM, 2.10E-08 RBD, or RNP domain) 252 U:280034.1 :2000SEP08 119 652 forward 2 AAA ATPase family associated with various 1.80E-64 cellular activities (AAA) 90 >- σ. + . o C -3 -3 D D C C 3 __. __! __! - c -- -- -- C -: -- -- -- C- -- C C C C Z . . C C . . C C. C o o o ~ o o o o _- -- O o o o o- - o- - o3 D o : o- o:3 o:- oD D o o:- z z z z z z z z z z z z z z z z z z z z z z z z z z o z z z un H U c α. σ ε 2 -5 -522222 :≥ 2 _ S _ 5 Σ1 255 Σ o CN CN -— O0 .— -O .- 0 .— OO r- cO CN — CM CN CN CN CO CN CN '— CN CN CO .— ■— ■— >— r- r- r- r- .— ,— -- -- -- ^ r- CN CN CN CN CN CN CN CN CN CN iδδδδδδδδδδδδδ σδδδσσδδδδδδδδδδδδδδδδδσδσσoσoσσσδδδ oooooooooooooooooooooooooooopppppppppppppppppppppp CN o o O TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topoloς 48 LG:236928.1:2000SEP08 2015 2101 forward 2 TM Nin 48 LG:236928.1:2000SEP08 2501 2587 forward 2 TM Nin 48 LG:236928.1:2000SEP08 2639 2716 forward 2 TM Nin 48 LG:236928.1:2000SEP08 2786 2872 forward 2 TM Nin 48 LG:236928.1:2000SEP08 2894 2980 forward 2 TM in 48 LG:236928.1:2000SEP08 471 551 forward 3 TM Nin 48 LG:236928.1:2000SEP08 738 824 forward 3 TM Nin 48 LG:236928.1:2000SEP08 1287 1340 forward 3 TM Nin 48 LG:236928.1:2000SEP08 1626 1712 forward 3 TM Nin 48 LG:236928.1:2000SEP08 1890 1976 forward 3 TM Nin 48 LG:236928.1:2000SEP08 2034 2120 forward 3 TM Nin 48 LG:236928.1:2000SEP08 2118 2186 forward 3 TM Nin 48 LG:236928.1:2000SEP08 2520 2591 forward 3 TM Nin 48 LG:236928.1:2000SEP08 2763 2846 forward 3 TM Nin 48 LG:236928.1:2000SEP08 2916 2978 forward 3 TM Nin 48 LG:236928.1:2000SEP08 3003 3065 forward 3 TM Nin 49 LG:215169.2:2000SEP08 1363 1413 forward 1 TM Nin 49 LG:215169.2:2000SEP08 503 589 forward 2 TM Nout 49 LG:215169.2:2000SEP08 1727 1813 forward 2 TM Nout 49 LG:215169.2:2000SEP08 237 302 forward 3 TM Nout 49 LG:215169.2:2000SEP08 837 923 forward 3 TM Nout 49 LG:215169.2:2000SEP08 1398 1460 forward 3 TM Nout 49 LG:215169.2:2000SEP08 1470 1532 forward 3 TM Nout 49 LG:215169.2:2000SEP08 1605 1658 forward 3 TM Nout 50 LG:410726.1:2000SEP08 31 93 forward 1 TM Nout 50 LG:410726.1:2000SEP08 115 177 forward 1 TM Nout 50 LG:410726.1:2000SEP08 463 549 forward 1 TM Nout 51 LG:234372.2:2000SEP08 325 411 forward 1 TM Nin 51 LG:234372.2:2000SEP08 2492 2578 forward 2 TM Nout 51 LG:234372.2:2000SEP08 2669 2743 forward 2 TM Nout 51 LG:234372.2:2000SEP08 723 809 forward 3 TM Nin 52 LG:022629.1:2000SEP08 268 354 forward 1 TM Nout 52 LG:022629.1:2000SEP08 385 459 forward 1 TM Nout 52 LG:022629.1:2000SEP08 559 645 forward 1 TM Nout 52 LG:022629.1:2000SEP08 796 882 forward 1 TM Nout 52 LG:022629.1:2000SEP08 281 358 forward 2 TM Nin 53 LG:068682.1:2000SEP08 707 793 forward 2 TM Nout 54 LG:222335.1:2000SEP08 847 933 forward 1 TM Nin 54 LG:222335.1:2000SEP08 973 1023 forward 1 TM Nin 54 LG:222335.1:2000SEP08 1030 1101 forward 1 TM Nin 54 LG:222335.1:2000SEP08 1216 1290 forward 1 TM Nin 54 LG:222335.1:2000SEP08 23 109 forward 2 TM 54 LG:222335.1:2000SEP08 314 373 forward 2 TM 54 LG:222335.1:2000SEP08 428 514 forward 2 TM 54 LG:222335.1:2000SEP08 728 784 forward 2 TM 54 LG:222335.1:2000SEP08 794 868 forward 2 TM 54 LG:222335.1:2000SEP08 965 1051 forward 2 TM 54 LG:222335.1:2000SEP08 603 674 forward 3 TM Nin 54 LG:222335.1:2000SEP08 921 983 forward 3 TM Nin 54 LG:222335.1:2000SEP08 1014 1076 forward 3 TM Nin CO CO — — CO — r- r- r- r- r- — CN CN CM CN CO CO CO CO CO CO — CM CO CO CO — CO CO CN CN CN CN CN CN CN CO — CN CN — — — CN CO — ■- ■- .- g δ δ δ δ δ δ δ δ δ δ δ σ δ δ δδ σ σ δδ δ δδ δ δ δ δ δ δδ δ δ δδ δδδ δ σδδ o δ δ σ δ δ σ δ "- o o o o o o o o o o o p .0.0.0 ,b .0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0 P .0.0.0.b .0.0.0.0.o .p .0.o .0.0.0.0 co o , — -o o O r- co rN. r-N co o rN. 3- o- - rN. j5 : - 00 -O CO n o o o n r-. ^r o •o L •o s o CN ■— cM -O 'T co o o co .N. M rN. rN. rN. o - CM -f . 00 O ( N . CM s o LO f 1 — 1 •o C CO N O" 1 *~ - r r- ^- CO 'ϊ rN. r- ^. L 0 ^O' ^ — l ^i N s 00 CN C CN ^ ^- N M CM-! 8 - ^ I^: r- CO o _2 CoO o o z PI '* , NJ L0 -0 L0 -0 -0 N0 3 -0 -0 NQ <) -0 -0 -0 -0 N0 NQ -0 -0 N0 ΓN. 00 00 00 00 O O O '— •— •— •— CN CN CN CN CO CO CO Q « Q -O -O -o o y -) U) ιO U) ιfi ιO -) ιO ιO -) -3 -) iO ιO -) -) ιn -) -) -) ιO W iO β ιO ιO W -> 0 0 0 '0 0 0 NQ NQ 0 O O -O o S O 33 L •o -o -o -o -o O G TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topoloς 66 LG 1045521.4:2000SEP08 3508 3582 forward 1 TM Nin 66 LG 1045521.4:2000SEP08 1652 1714 forward 2 TM Nin 66 LG 1045521.4:2000SEP08 2444 2500 forward 2 TM Nin 66 LG 1045521.4:2000SEP08 2627 2713 forward 2 TM Nin 66 LG 1045521.4:2000SEP08 3017 3088 forward 2 TM Nin 66 LG 1045521.4:2000SEP08 3317 3385 forward 2 TM Nin 66 LG 1045521.4:2000SEP08 1530 1604 forward 3 TM Nin 66 LG 1045521.4:2000SEP08 2496 2549 forward 3 TM Nin 66 LG 1045521.4:2000SEP08 2931 3017 forward 3 TM Nin 66 LG 1045521.4:2000SEP08 3267 3341 forward 3 TM Nin 67 LG:275876.1:2000SEP08 775 849 forward 1 TM Nin 67 LG:275876.1:2000SEP08 949 1002 forward 1 TM Nin 67 LG:275876.1:2000SEP08 842 928 forward 2 TM Nout 67 LG:275876.1:2000SEP08 777 842 forward 3 TM Nin 68 LG:475127.7:2000SEP08 137 223 forward 2 TM Nin 69 LG:157263.1:2000SEP08 175 249 forward 1 TM Nin 69 LG:157263.1:2000SEP08 295 345 forward 1 TM Nin 69 LG:157263.1:2000SEP08 406 492 forward 1 TM Nin 69 LG:157263.1:2000SEP08 793 867 forward 1 TM Nin 69 LG:157263.1:2000SEP08 889 951 forward 1 TM Nin 69 LG:157263.1:2000SEP08 1081 1143 forward 1 TM Nin 69 LG:157263.1:2000SEP08 1168 1230 forward 1 TM Nin 69 LG:157263.1:2000SEP08 1255 1341 forward 1 TM Nin 69 LG:157263.1:2000SEP08 482 544 forward 2 TM Nout 69 LG:157263.1:2000SEP08 563 625 forward 2 TM Nout 69 LG:157263.1:2000SEP08 180 266 forward 3 TM Nout 70 LG:247382.7:2000SEP08 808 894 forward 1 TM 70 LG:247382.7:2000SEP08 650 709 forward 2 TM Nout 70 LG:247382.7:2000SEP08 1412 1495 forward 2 TM Nout 71 LG:197367.5:2000SEP08 454 510 forward 1 TM Nout 72 LG:218090.5:2000SEP08 85 156 forward 1 TM Nout 72 LG:218090.5:2000SEP08 417 494 forward 3 TM Nout 73 LG:216612.4:2000SEP08 1615 1701 forward 1 TM Nin 73 LG:216612.4:2000SEP08 1942 2007 forward 1 TM Nin 73 LG:216612.4:2000SEP08 2182 2268 forward 1 TM Nin 73 LG:216612.4:2000SEP08 2413 2487 forward 1 TM Nin 73 LG:216612.4:2000SEP08 1583 1660 forward 2 TM Nin 73 LG:216612.4:2000SEP08 2114 2176 forward 2 TM Nin 73 LG:216612.4:2000SEP08 2216 2278 forward 2 TM Nin 73 LG:216612.4:2000SEP08 2339 2425 forward 2 TM Nin 73 LG:216612.4:2000SEP08 2483 2542 forward 2 TM Nin 73 LG:216612.4:2000SEP08 120 206 forward 3 TM Nin 73 LG:216612.4:2000SEP08 234 284 forward 3 TM Nin 73 LG:216612.4:2000SEP08 327 413 forward 3 TM Nin 73 LG:216612.4:2000SEP08 444 530 forward 3 TM Nin 73 LG:216612.4:2000SEP08 810 896 forward 3 TM Nin 73 LG:216612.4:2000SEP08 942 1028 forward 3 TM Nin 73 LG:216612.4:2000SEP08 1644 1730 forward 3 TM Nin 73 LG:216612.4:2000SEP08 1950 2012 forward 3 TM Nin 73 LG:216612.4:2000SEP08 2037 2099 forward 3 TM Nin 107 m D MMNMMM N MMNM MM MMM MM M MM M MMMM MMMM MNM MMM MM MMM M MMMM MM N Nj o o o w w cn cn n i cjι ι ^ J-- Ji- j . j-- -- --- 4-- j-- ^ 4-- j^ j-. -- ^ ω ω u O 00000000000000000000000000000000000000000000000000 ω iό fό ro NJ ro to rό ro ro ro w ω ω ω c- cό o- cό CI. CB 0 ) α ) C» αJ 0 ) 0! ( » 0 ) C0 M M N N M Nl N ^ M O O '0 O O O O O O O O O O O - , - , . -0 O O 00 00 00 C» » C» » 00 00 ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ -^ -^ ^ ^ ^ ^ ^ ^ -^ -^ -^ j N j ^ -^ 0- ^ 00 O O O O O O O O O J J J-' J -- --- J -t-» --- 4^' O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O -! N co ω c- ω c G- -o ω ω ω ro ro ro ro ro ro ro ro ro — . --- --- — . _. __ _. _-, _ _. ■ __, __ -_ j _- --- --- --- --- --- --- --- --- --- --_ --- --- _- __ __ _i _3 o ) o <) ! o J ) <ι oo oo oo oo oo oo cD ω o. ^ J- ^ t- 4- J-. ^ ^ J- t- J_ Ji |_. J_1 i_ . ) ^ ' ? - TT 77- TT 1 7? 77- ' TT 1 T7- TT- ' T 1 N3 M M M M M M M rO M W M M S3 M M N) N) M N) W I M M M I M M S3 N) N3 N) 3 M M O O OO O O O OO OOO O OO O O O O O OO O OOO O O O O OOO O O O O O O O O O OO OO O O O O Φ OQQ. Q. Q O O O O OOQ O OO O O O O O OO O O OO O O O O O OO O OOO O O O O O OO O O OO O O — obpoooopoppopoooooooooooooooooooooooooooooooooooooD m m m πι rτι m m m m rπ m rπ m m m m m m m m m rπ rπ rπ rπ rπ [τι m rπ m rτι rπ m m m m m m rπ m 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CO CO CX> C» 00 CX- 00 00 00 C» C0 CO 00 a> C» O0 CX. rø 00 a> rø 0 >3 — — — ' f j — • -_. — — — — -O- oo K i S Nj δ- i ω Co N J 01 01 00 ro ro 00 ro o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o - r , Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q D Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q d ddd -id &d Qad Q d d Q Qd -•UωU MM -' -'-' - ' - ' U UUU M ^ ^^ - ' WWU WωOM MM M MMMNJ MMM KJ I -' -' -' - ' -' - ' -' -' -' UCJ 2 2 zzzz zz 2z zzzzz O O O O O — -. O O O O — — — — -. ooooooooooooo z~ z~ z z~ ~ — ??-- £- o C C C C -3 -3 C C C C -3 3 -3 _3 _3 ~ C → C→ C→ C→ C→ C→ C→ C→ C→ -→I C→ C→ C→ -- i 3 -3 -3 D --- -3 D -- i -3 -3 C0Q TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topology 77 LG:389870.1:2000SEP08 1055 1120 forward 2 TM Nin 77 LG:389870.1:2000SEP08 1059 1142 forward 3 TM Nin 78 LG:1387485.6:2000SEP08 1213 1275 forward 1 TM Nin 78 LG:1387485.6:2000SEP08 206 292 forward 2 TM Nin 78 LG:1387485.6:2000SEP08 824 886 forward 2 TM Nin 78 LG:1387485.6:2000SEP08 914 976 forward 2 TM Nin 78 LG:1387485.6:2000SEP08 1244 1321 forward 2 TM Nin 78 LG: 1387485.6:2000SEP08 396 473 forward 3 TM Nout 78 LG:1387485.6:2000SEP08 537 602 forward 3 TM Nout 78 LG:1387485.6:2000SEP08 660 746 forward 3 TM Nout 78 LG: 1387485.6:2000SEP08 786 872 forward 3 TM Nout 78 LG: 1387485.6:2000SEP08 1164 1226 forward 3 TM Nout 78 LG:1387485.6:2000SEP08 1245 1307 forward 3 TM Nout 79 LG:230151.1:2000SEP08 1774 1860 forward 1 TM Nin 79 LG:230151.1:2000SEP08 1091 1165 forward 2 TM Nout 79 LG:230151.1:2000SEP08 1193 1246 forward 2 TM Nout 79 LG:230151.1:2000SEP08 1757 1843 forward 2 TM Nout 80 LG:215158.5:2000SEP08 199 267 forward 1 TM Nout 80 LG:215158.5:2000SEP08 820 873 forward 1 TM Nout 80 LG:215158.5:2000SEP08 892 945 forward 1 TM Nout 80 LG:215158.5:2000SEP08 908 985 forward 2 TM Nout 80 LG:215158.5:2000SEP08 1433 1504 forward 2 TM Nout 80 LG:215158.5:2000SEP08 447 533 forward 3 TM 81 LG:235840.1:2000SEP08 265 342 forward 1 TM Nout 81 LG:235840.1:2000SEP08 511 579 forward 1 TM Nout 81 LG:235840.1:2000SEP08 577 639 forward 1 TM Nout 81 LG:235840.1:2000SEP08 730 786 forward 1 TM Nout 81 LG:235840.1:2000SEP08 2011 2082 forward 1 TM Nout 81 LG:235840.1:2000SEP08 2110 2172 forward 1 TM Nout 81 LG:235840.1:2000SEP08 2326 2406 forward 1 TM Nout 81 LG:235840.1:2000SEP08 2416 2502 forward 1 TM Nout 81 LG:235840.1:2000SEP08 116 178 forward 2 TM Nout 81 LG:235840.1:2000SEP08 191 253 forward 2 TM Nout 81 LG:235840.1 :2000SEP08 500 586 forward 2 TM Nout 81 LG:235840.1:2000SEP08 731 817 forward 2 TM Nout 81 LG:235840.1:2000SEP08 848 916 forward 2 TM Nout 81 LG:235840.1:2000SEP08 956 1030 forward 2 TM Nout 81 LG:235840.1:2000SEP08 1973 2050 forward 2 TM Nout 81 LG:235840.1:2000SEP08 192 278 forward 3 TM Nout 81 LG:235840.1:2000SEP08 516 590 forward 3 TM Nout 81 LG:235840.1:2000SEP08 711 797 forward 3 TM Nout 81 LG:235840.1:2000SEP08 819 905 forward 3 TM Nout 81 LG:235840.1:2000SEP08 1446 1529 forward 3 TM Nout 81 LG:235840.1:2000SEP08 1893 1976 forward 3 TM Nout 81 LG:235840.1:2000SEP08 2298 2360 forward 3 TM Nout 82 LG:350272.1:2000SEP08 1675 1746 forward 1 TM Nin 82 LG:350272.1:2000SEP08 2374 2436 forward 1 TM Nin 82 LG:350272.1:2000SEP08 104 190 forward 2 TM Nin 82 LG:350272.1:2000SEP08 2264 2332 forward 2 TM Nin 82 LG:350272.1:2000SEP08 2369 2440 forward 2 TM Nin CO cO CO CO — -- CN CN CM CM CN CO CO CO CO — — CN CN CO cO CN CO cO CO CN CM CN — .— — — CN CO CM CO — — CM CN CO CO CM '- CN CO CO — — — ' 2δTδb ' 2δ ' 5δ ' 5b ' δ--! ' 5δ ' 2δδ ' 2δσδ " 2 " 2δ ' δ--:δ ' 5δ " 2δ ' 2δ ' 5δ " 2δ " 2δ ' 2δ ' 2δ ' 5δ " 2δ " 5δ " 5δ " 2δ ' 2δ ' 2δ ' 2δ ' 2δ ' 5δ ' 2δ ' 2δδ ' 2b ' 2δ " 2δ " 2δ ' 2δ ' 2σ ' 2δδ ' 2δ ' 2δ ' 2δ " 2δ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o CM CO fe S cN ~i CD - 8; § a as O < o o z Q CN CN N N c o o o n n o o n n ^ ιo ι_) i_) ifi i ifi N <o <> (> θ '- c. c. c. c. N ! , ) n ^ ^ , ϊ ^ '. ^ -) -o <) N eo o CO 00 C0 C0 C0 C0 C0 C0 C0 -0 C0 C0 00 00 C0 C0 C0 C0 C0 00 00 C0 00 00 00 C0 00 O O O O O O G LU CO 0 — o o o o o o o o o o o o o o o o o o o o o o o o o o o o o O F cn en <_n en en en en oi --- co e»- ro — ' O o o o o o -o -θ Nθ -o oo N e> o en en n j_- -- 4-- j-- j-- e cΛ. CΛ) ro ro N N — ■ — • — - o o J O o J! O o o o o o o o o o o o o o o o o ooo o o o o o o o o o o o o o o o ooo o o o o o o o o o o o o o Q Q Q Q O Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q ddddddddddddddddddddddddddddddddddddddddd dddddddd ω ω r ι - - j -' --- ω M -- - j ro ω ω - j ^ -' ^ ω w - - ^ ω ω - - j N_ ^ - ω ω r M - ω r -- - j -' ^ -' 3 . ι M ≤ ~ ≤z ~ ~ ~ ~ ≤ ≤ ~ - ~ ~ ~ ~ ~ ≤ ≤ <ι < - ~ z ^ z z z z z z zz z z zzzzzzz -z.-z.-z.-z.-z. z z z z z z z z z zzz z zzzz Z Z Z Z ZΌ O C OC —3 -3. —3 -3. —3 -3. OC OC_ OC: —3 —3 o--: o-- o-- o-- oC o-- o-- O-: O-: O-: O-: O-: -3. -3.0c 0c_ 0_: 0c 0c -3. _3 Oc O__: Oc -3. oc oc o__: oc o o o o o 0. c _r c c c o -< TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topology 116 LG:885747.2:2000SEP08 125 205 forward 2 TM Nin 116 LG:885747.2:2000SEP08 135 191 forward 3 TM Nout 116 LG:885747.2:2000SEP08 189 239 forward 3 TM Nout 117 LG 1140501.1:2000SEP08 622 708 forward 1 TM Nout 117 LG 1140501 1:2000SEP08 844 918 forward 1 TM Nout 117 LG 1140501 1 :2000SEP08 1138 1206 forward 1 TM Nout 117 LG 1140501 1 :2000SEP08 86 169 forward 2 TM Nout 117 LG 1140501 1 :2000SEP08 221 301 forward 2 TM Nout 117 LG 1140501 1 :2000SEP08 617 703 forward 2 TM Nout 117 LG 1140501 1 :2000SEP08 606 677 forward 3 TM Nin 118 LG:001239.1:2000SEP08 1048 1122 forward 1 TM Nout 118 LG:001239.1:2000SEP08 669 755 forward 3 TM Nout 118 LG:001239.1:2000SEP08 1911 1976 forward 3 TM Nout 119 LG:018980.1:2000SEP08 124 204 forward 1 TM Nout 119 LG:018980.1 :2000SEP08 944 997 forward 2 TM Nout 119 LG:018980.1 :2000SEP08 405 464 forward 3 TM Nout 119 LG:018980.1 :2000SEP08 900 986 forward 3 TM Nout 119 LG:018980.1 :2000SEP08 1017 1103 forward 3 TM Nout 120 LG:1083120.3:2000SEP08 214 291 forward 1 TM Nout 120 LG:1083120.3:2000SEP08 233 319 forward 2 TM Nout 120 LG: 1083120.3:2000SEP08 252 320 forward 3 TM Nin 121 LG:233258.3:2000SEP08 58 141 forward 1 TM 121 LG:233258.3:2000SEP08 1783 1842 forward 1 TM 121 LG:233258.3:2000SEP08 2248 2322 forward 1 TM 121 LG:233258.3:2000SEP08 4522 4596 forward 1 TM 121 LG:233258.3:2000SEP08 4208 4294 forward 2 TM Nout 121 LG:233258.3:2000SEP08 4478 4534 forward 2 TM Nout 121 LG:233258.3:2000SEP08 390 476 forward 3 TM Nin 121 LG:233258.3:2000SEP08 2766 2852 forward 3 TM Nin 122 LG:999062.1:2000SEP08 455 508 forward 2 TM Nin 122 LG:999062.1 :2000SEP08 510 596 forward 3 TM in 123 LG:887776.1:2000SEP08 14 91 forward 2 TM Nout 124 LG: 1400301.2:2000SEP08 445 531 forward 1 TM Nout 124 LG: 1400301.2:2000SEP08 456 518 forward 3 TM Nout 125 LG:1329362.1:2000SEP08 18 104 forward 3 TM Nout 126 LG: 1096498.1:2000SEP08 137 199 forward 2 TM out 126 LG: 1096498.1:2000SEP08 201 269 forward 3 TM Nout 126 LG: 1096498.1 :2000SEP08 321 371 forward 3 TM Nout 127 LG: 1096337.1:2000SEP08 625 711 forward 1 TM Nout 127 LG: 1096337.1:2000SEP08 500 553 forward 2 TM 128 LG: 1400579.1:2000SEP08 797 883 forward 2 TM Nout 128 LG: 1400579.1:2000SEP08 9 86 forward 3 TM Nout 128 LG: 1400579.1:2000SEP08 669 755 forward 3 TM Nout 129 LG:1080091.1:2000SEP08 67 114 forward 1 TM Nout 129 LG: 1080091.1:2000SEP08 435 497 forward 3 TM Nout 130 LG: 1082203.1 :2000SEP08 1438 1521 forward 1 TM Nin 130 LG:1082203.1:2000SEP08 155 217 forward 2 TM Nout 130 LG: 1082203.1:2000SEP08 272 358 forward 2 TM Nout 131 LG: 1084051.1 :2000SEP08 301 366 forward 1 TM Nout 131 LG 1084051 1 :2000SEP08 934 1017 forward 1 TM Nout TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topology 131 LG: 1084051.1:2000SEP08 1072 1140 forward 1 TM Nout 131 LG: 1084051.1:2000SEP08 875 961 forward 2 TM Nout 131 LG: 1084051.1:2000SEP08 882 968 forward 3 TM Nin 131 LG: 1084051.1:2000SEP08 1071 1151 forward 3 TM Nin 132 LG:1082393.1:2000SEP08 505 579 forward 1 TM Nin 132 LG: 1082393.1:2000SEP08 1710 1784 forward 3 TM Nin 133 LG:1086183.1:2000SEP08 1093 1179 forward 1 TM Nout 133 LG:1086183.1:2000SEP08 1166 1252 forward 2 TM Nin 133 LG:1086183.1:2000SEP08 15 86 forward 3 TM 133 LG:1086183.1:2000SEP08 381 437 forward 3 TM 133 LG: 1086183.1:2000SEP08 1194 1280 forward 3 TM 134 LG:1090268.1:2000SEP08 1882 1953 forward 1 TM Nout 134 LG:1090268.1:2000SEP08 1969 2055 forward 1 TM Nout 134 LG:1090268.1:2000SEP08 1670 1729 forward 2 TM Nout 134 LG:1090268.1:2000SEP08 1853 1939 forward 2 TM Nout 134 LG:1090268.1:2000SEP08 1997 2083 forward 2 TM Nout 134 LG: 1090268.1 :2000SEP08 1485 1550 forward 3 TM Nin 134 LG:1090268.1:2000SEP08 1869 1943 forward 3 TM Nin 134 LG: 1090268.1:2000SEP08 1962 2048 forward 3 TM Nin 135 LG: 1400597.5:2000SEP08 134 199 forward 2 TM Nin 136 LG:1080307.2:2000SEP08 275 346 forward 2 TM Nout 136 LG:1080307.2:2000SEP08 347 403 forward 2 TM Nout 136 LG:1080307.2:2000SEP08 183 269 forward 3 TM Nin 136 LG:1080307.2:2000SEP08 303 371 forward 3 TM Nin 137 LG:1400603.2:2000SEP08 792 878 forward 3 TM Nin 137 LG:1400603.2:2000SEP08 903 971 forward 3 TM Nin 137 LG:1400603.2:2000SEP08 1068 1151 forward 3 TM Nin 138 LG: 1052984.1:2000SEP08 496 582 forward 1 TM Nin 138 LG: 1052984.1 :2000SEP08 509 595 forward 2 TM Nout 138 LG: 1052984.1:2000SEP08 495 581 forward 3 TM 139 LG:1091259.1:2000SEP08 799 885 forward 1 TM Nin 140 LG:1082263.2:2000SEP08 1390 1458 forward 1 TM Nin 140 LG:1082263.2:2000SEP08 1558 1644 forward 1 TM Nin 140 LG:1082263.2:2000SEPO8 83 169 forward 2 TM 140 LG:1082263.2:2000SEPO8 1526 1612 forward 2 TM 140 LG:1082263.2:2000SEP08 1578 1664 forward 3 TM Nin 141 LG: 1048604.2:2000SEP08 562 618 forward 1 TM Nin 141 LG: 1048604.2:2000SEP08 697 768 forward 1 TM Nin 141 LG: 1048604.2:2000SEP08 856 930 forward 1 TM Nin 141 LG:1048604.2:2000SEP08 332 418 forward 2 TM Nin 141 LG: 1048604.2:2000SEP08 689 775 forward 2 TM Nin 141 LG: 1048604.2:2000SEP08 1115 1192 forward 2 TM Nin 141 LG: 1048604.2:2000SEP08 483 557 forward 3 TM Nin 141 LG: 1048604.2:2000SEP08 570 638 forward 3 TM Nin 141 LG: 1048604.2:2000SEP08 678 743 forward 3 TM Nin 141 LG: 1048604.2:2000SEP08 1113 1199 forward 3 TM Nin 142 LG: 1085254.3:2000SEP08 331 378 forward 1 TM Nin 142 LG:1085254.3:2000SEP08 204 290 forward 3 TM Nout 143 LG:1400606.2:2000SEP08 1096 1176 forward 1 TM Nout 143 LG: 1400606.2:2000SEP08 794 880 forward 2 TM Nin TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topology 143 LG 1400606.2:2000SEP08 1031 1117 forward 2 TM Nin 143 LG 1400606.2:2000SEP08 93 173 forward 3 TM Nin 143 LG 1400606.2:2000SEP08 765 851 forward 3 TM Nin 144 LG 1090358.2:2000SEP08 250 336 forward 1 TM Nin 144 LG 1090358.2:2000SEP08 758 844 forward 2 TM Nout 144 LG 1090358.2:2000SEP08 848 919 forward 2 TM Nout 144 LG 1090358.2:2000SEP08 974 1060 forward 2 TM Nout 145 LG 1079064.2:2000SEP08 862 936 forward 1 TM Nout 146 LG 1076866.1:2000SEP08 2113 2187 forward 1 TM Nin 146 LG 1076866.1:2000SEP08 2111 2170 forward 2 TM 146 LG 1076866.1:2000SEP08 50 V 587 forward 3 TM Nin 146 LG 1076866.1:2000SEP08 2148 2234 forward 3 TM Nin 147 LG:969359.1:2000SEP08 256 303 forward 1 TM Nout 147 LG:969359.1:2000SEP08 276 350 forward 3 TM Nout 148 LG:366783.1:2000SEP08 1060 1143 forward 1 TM Nin 148 LG:366783.1:2000SEP08 470 550 forward 2 TM 148 LG:366783.1:2000SEP08 1050 1109 forward 3 TM Nin 149 LG:332176.3:2000SEP08 442 495 forward 1 TM Nin 149 LG:332176.3:2000SEP08 209 295 forward 2 TM Nin 149 LG:332176.3:2000SEP08 234 299 forward 3 TM Nin 149 LG:332176.3:2000SEP08 792 851 forward 3 TM Nin 149 LG:332176.3:2000SEP08 876 938 forward 3 TM Nin 149 LG:332176.3:2000SEP08 966 1028 forward 3 TM Nin 150 LG:994938.1:2000SEP08 562 618 forward 1 TM Nout 150 LG:994938.1:2000SEP08 287 343 forward 2 TM Nout 150 LG:994938.1:2000SEP08 512 598 forward 2 TM Nout 150 LG:994938.1:2000SEP08 279 356 forward 3 TM Nout 150 LG:994938.1:2000SEP08 474 557 forward 3 TM Nout 151 LG:982800.1:2000SEP08 25 81 forward 1 TM Nout 151 LG:982800.1:2000SEP08 1708 1782 forward 1 TM Nout 151 LG:982800.1:2000SEP08 2305 2391 forward 1 TM Nout 151 LG:982800.1:2000SEP08 1658 1744 forward 2 TM Nin 151 LG:982800.1:2000SEP08 1880 1927 forward 2 TM Nin 151 LG:982800.1:2000SEP08 2255 2341 forward 2 TM Nin 151 LG:982800.1:2000SEP08 1614 1697 forward 3 TM Nin 151 LG:982800.1:2000SEP08 2220 2306 forward 3 TM Nin 152 LG:977850.7:2000SEP08 58 144 forward 1 TM Nout 152 LG:977850.7:2000SEP08 187 237 forward 1 TM Nout 152 LG:977850.7:2000SEP08 35 112 forward 2 TM Nout 152 LG:977850J:2000SEP08 48 116 forward 3 TM Nin 153 LG:234748.2:2000SEP08 25 99 forward 1 TM out 153 LG:234748.2:2000SEP08 601 663 forward 1 TM Nout 153 LG:234748.2:2000SEP08 679 741 forward 1 TM Nout 153 LG:234748.2:2000SEPO8 871 957 forward 1 TM Nout 153 LG:234748.2:2000SEP08 1162 1230 forward 1 TM Nout 153 LG:234748.2:2000SEP08 1237 1302 forward 1 TM out 153 LG:234748.2:2000SEP08 1579 1641 forward 1 TM Nout 153 LG:234748.2:2000SEP08 1984 2070 forward 1 TM Nout 153 LG:234748.2:2000SEP08 2110 2196 forward 1 TM Nout 153 LG:234748.2:2000SEP08 2308 2355 forward 1 TM Nout 90 CM >. CD I-- O O ._= ._= ._= ._= .£ .<= ._= .£ £._=.__• D ._Ξ .£ . C C 3 3 3 3 3 3 C C C 3 C c c c g CM _Ξ ._= ... — — o o o o o o — — O α zzzzzzzzzzz z zzzzz °z z z z z CΛ o H U c α. o ε -≥ -≥ - Σ 2 _≥ _> Σ _> 2 o Q (N CM CN CM CN CN CN CN CN C CN CO CO CO CO CO CO CO CO CO CO CN '— ■— CO -— O r- r— ■— CN CN C cO cO cO -— — CN CN C -- ■— ■— ■— ■— CN CM CN CN g δ b σ δ δ b δ δ δ α δ δ δ δ δ δ δ δ δ σ δδ σ δ δ δ σ σ δ σ δ δ δδ δ δ σδ σ δδδ δ δ δ δ δ δ δ δ " ■ 00000000000000000000000000000000 pop.p.po op op o oo Q- — _ CN -O r- -Λ 'NT - f o u S o LQ - r. o co O CM CM 'Nt , " f r N . }5 o S cM r N . S cN θ _o o -o c o "st LO ΓN. N - ι- °' w 0, c. -. ° 'T r- o «) r. c. N eo I-- o O _ co c c CJ cθ c cθ cθ cθ cj cθ cθ ( cθ co co co cθ -O co ^f rN. cθ O O O r— r— r- r— r- r— - N N r O n n t t lO -O O 'O O O O Q u j - j - Lθ Lθ Lθ -o - L Lθ j -o - Lθ Lθ j uj j rN. rN. rN. | N , oo oo oo co co oo oo oo oo co co oo oo oo co co rø o O C C C r- r- CJ CJ C CO C CJ r- r- r- r- r- r- r- r- r- r- r- CN CN CN CN CM CJ C CJ CJ CJ CJ CJ r- r- r- CN CM C CN C^ P ' 2 P ' PP? ? ' 2?P ' 2 ' 2PPO? ' PP ' 2 ' 2P??P Ϊ P ' 2 P δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ δ α δ δ b b δ δ δ δ δ σ b δ σ b δ δ b b δ δ δ δ p p p p p p p p p p p p p p p p p p p p p p p p p p p o p p p p p p p p p p p p p p p p p p p p p p o N ? _ π w " r ι5- NSl rN § O 1 _. l _. ' O N O » -. -. r . -. p . w >- ι _ ι _ I-- o ^ ■0 -θ Nθ rN. r. r-N rN. rN. rN. rN. rN. oo o o o o o o o o o o o o o o o Q θ o p Q θ θ θ θ - r- r- ϋ » eo cθ cθ (D eo o_ _ oo oθ ffl (0 (0 -3 co co «) eo oo co eθ (θ eo ιO -) -J oj !D co ι» oo oo co ι» 5 ' (> C> 5 θ' (> 5 ^ 0> C. α θ' 0 ' (> o O G TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topology 191 U:027209.1:2000SEP08 1447 1533 forward 1 TM Nout 191 U .0272091 :2000SEP08 413 475 forward 2 TM Nout 191 U:027209.1:2000SEP08 527 601 forward 2 TM Nout 191 U:027209.1:2000SEP08 659 739 forward 2 TM Nout 191 U:027209.1:2000SEP08 785 847 forward 2 TM Nout 191 LI:027209.1:2000SEP08 1178 1234 forward 2 TM Nout 191 U:027209.1:2000SEP08 1232 1309 forward 2 TM Nout 191 U:027209.1:2000SEP08 1379 1465 forward 2 TM Nout 191 U:027209.1:2000SEP08 510 563 forward 3 TM Nin 191 U:027209.1:2000SEP08 882 938 forward 3 TM Nin 191 LI:027209.1:2000SEP08 945 1016 forward 3 TM Nin 191 LI:027209.1:2000SEP08 1041 1112 forward 3 TM Nin 191 LI:027209.1:2000SEP08 1146 1208 forward 3 TM Nin 191 U:027209.1:2000SEP08 1224 1286 forward 3 TM Nin 192 LI:108819.1:2000SEP08 196 264 forward 1 TM Nin 192 U:108819.1:2000SEP08 203 271 forward 2 TM 192 LI:108819.1:2000SEP08 290 343 forward 2 TM 193 U:021759.1:2000SEP08 133 186 forward 1 TM Nout 193 LI:021759.1:2000SEP08 59 115 forward 2 TM Nout 193 LI:021759.1:2000SEP08 495 581 forward 3 TM Nin 193 U:021759.1:2000SEP08 981 1067 forward 3 TM Nin 194 U:1165967.1:2000SEP08 323 403 forward 2 TM Nout 195 U:1166315.1:2000SEP08 693 749 forward 3 TM Nout 196 LI:204626.1:2000SEP08 19 99 forward 1 TM Nout 197 Ll:801140.1 :2000SEP08 421 498 forward 1 TM Nin 198 U:286639.1:2000SEP08 127 213 forward 1 TM Nout • 198 LI:286639.1:2000SEP08 982 1068 forward 1 TM Nout 198 LI:286639.1:2000SEP08 1879 1944 forward 1 TM Nout 198 U:286639.1:2000SEP08 62 148 forward 2 TM Nout 198 LI:286639.1:2000SEP08 965 1027 forward 2 TM Nout 198 LI:286639.1:2000SEP08 1061 1123 forward 2 TM Nout 198 U:286639.1:2000SEP08 1589 1663 forward 2 TM Nout 198 U:286639.1:2000SEP08 1787 1873 forward 2 TM Nout 198 U:286639.1:2000SEP08 267 320 forward 3 TM Nout 198 U:286639.1:2000SEP08 1794 1847 forward 3 TM Nout 199 U:288905.4:2000SEP08 868 927 forward 1 TM Nout 199 LI:288905.4:2000SEP08 1552 1638 forward 1 TM Nout 199 LI:288905.4:2000SEP08 1913 1975 forward 2 TM Nout 199 LI:288905.4:2000SEP08 2000 2062 forward 2 TM Nout 199 U:288905.4:2000SEP08 99 158 forward 3 TM Nin 200 U:332161.1:2000SEP08 1507 1587 forward 1 TM Nin 200 U:332161.1:2000SEP08 1663 1743 forward 1 TM Nin 200 U:332161.1:2000SEP08 2314 2400 forward 1 TM Nin 200 LI:332161.1:2000SEP08 2890 2940 forward 1 TM Nin 200 LI:332161.1:2000SEP08 776 835 forward 2 TM 200 LI:332161.1:2000SEP08 1340 1393 forward 2 TM 200 LI:332161.1:2000SEP08 1493 1579 forward 2 TM 200 U:332161.1:2000SEP08 1637 1717 forward 2 TM 200 U:332161.1:2000SEP08 1880 1966 forward 2 TM 200 LI:332161.1:2000SEP08 2075 2161 forward 2 TM TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topoloς 200 U:332161.1:2000SEP08 2744 2818 forward 2 TM 200 U:332161.1:2000SEP08 258 311 forward 3 TM Nin 200 U:332161.1:2000SEP08 1524 1610 forward 3 TM Nin 200 U:332161.1:2000SEP08 2025 2111 forward 3 TM Nin 200 LI:332161.1:2000SEP08 2289 2375 forward 3 TM Nin 201 LI: 184867.1:2000SEP08 1985 2041 forward 2 TM Nin 201 LI: 184867.1:2000SEP08 771 854 forward 3 TM Nout 202 U:229932.4:2000SEP08 76 162 forward 1 TM Nout 202 U:229932.4:2000SEP08 229 300 forward 1 TM Nout 202 U:229932.4:2000SEP08 1249 1329 forward 1 TM Nout 202 U:229932.4:2000SEP08 1438 1524 forward 1 TM Nout 202 U:229932.4:2000SEP08 1678 1764 forward 1 TM Nout 202 U:229932.4:2000SEP08 68 142 forward 2 TM Nout 202 U:229932.4:2000SEP08 215 271 forward 2 TM Nout 202 U:229932.4:2000SEP08 734 820 forward 2 TM Nout 202 U:229932.4:2000SEP08 1220 1291 forward 2 TM Nout 202 U:229932.4:2000SEP08 1565 1618 forward 2 TM Nout 202 LI:229932.4:2000SEP08 60 146 forward 3 TM 202 LI:229932.4:2000SEP08 348 425 forward 3 TM 202 U:229932.4:2000SEP08 762 848 forward 3 TM 202 LI:229932.4:2000SEP08 1239 1325 forward 3 TM 202 LI:229932.4:2000SEP08 1401 1487 forward 3 TM 202 LI:229932.4:2000SEP08 1629 1703 forward 3 TM 203 LI: 1189932.1 2000SEP08 277 363 forward 1 TM Nout 203 LI: 1189932.1 2000SEP08 1141 1203 forward 1 TM Nout 203 LI: 1189932.1 2000SEP08 1216 1278 forward 1 TM Nout 203 LI: 1189932.1 2000SEP08 1411 1497 forward 1 TM Nout 203 LI: 1189932.1 2000SEP08 1642 1707 forward 1 TM Nout 203 LI: 1189932.1 2000SEP08 1795 1881 forward 1 TM Nout 203 LI: 1189932.1 2000SEP08 2125 2211 forward 1 TM Nout 203 LI: 1189932.1 2000SEP08 89 151 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 218 304 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 320 388 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 386 451 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 572 643 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 1142 1222 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 1412 1498 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 1928 1990 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 2021 2107 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 2141 2227 forward 2 TM Nin 203 LI: 1189932.1 2000SEP08 522 608 forward 3 TM Nout 203 U: 1189932.1 2000SEP08 858 944 forward 3 TM Nout 203 U: 1189932.1 2000SEP08 1161 1247 forward 3 TM Nout 203 LI: 1189932.1 2000SEP08 1992 2066 forward 3 TM Nout 203 LI: 1189932.1 2000SEP08 2139 2210 forward 3 TM Nout 204 LI: 1076689.1 2000SEP08 43 114 forward 1 TM Nin 204 LI: 1076689.1 2000SEP08 326 373 forward 2 TM Nin 205 LI:415181.2:2000SEP08 1033 1113 forward 1 TM Nin 205 LI:415181.2:2000SEP08 1363 1434 forward 1 TM Nin 205 Ll:415181.2:_ 2000SEP08 914 1000 forward 2 TM TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topology 206 LI:296358.1:2000SEP08 760 819 forward 1 TM Nout 206 LI:296358.1:2000SEP08 997 1068 forward 1 TM Nout 206 LI:296358.1:2000SEP08 1147 1233 forward 1 TM Nout 206 LI:296358.1:2000SEP08 197 247 forward 2 TM Nout 206 LI:296358.1:2000SEP08 356 442 forward 2 TM Nout 207 LI:205186.3:2000SEP08 644 697 forward 2 TM Nin 207 LI:205186.3:2000SEP08 812 877 forward 2 TM Nin 208 LI:220537.2:2000SEP08 595 681 forward 1 TM Nin 208 LI:220537.2:2000SEP08 1429 1515 forward 1 TM Nin 208 LI:220537.2:2000SEP08 245 331 forward 2 TM Nout 208 U:220537.2:2000SEP08 362 415 forward 2 TM out 208 U:220537.2:2000SEP08 1058 1129 forward 2 TM Nout 208 U:220537.2:2000SEP08 1136 1222 forward 2 TM Nout 208 LI:220537.2:2000SEP08 1472 1555 forward 2 TM Nout 208 LI:220537.2:2000SEP08 1820 1897 forward 2 TM Nout 208 LI:220537.2:2000SEP08 216 299 forward 3 TM Nout 208 LI:220537.2:2000SEP08 447 509 forward 3 TM Nout 208 LI:220537.2:2000SEP08 522 584 forward 3 TM Nout 208 LI:220537.2:2000SEP08 624 686 forward 3 TM Nout 208 LI:220537.2:2000SEP08 702 764 forward 3 TM Nout 208 U:220537.2:2000SEP08 1467 1553 forward 3 TM Nout 208 LI:220537.2:2000SEP08 1806 1892 forward 3 TM Nout 209 U:248364.2:2000SEP08 439 495 forward 1 TM Nout 210 LI:2048338.1:2000SEP08 268 354 forward 1 TM Nin 210 U:2048338.1:2000SEP08 385 459 forward 1 TM Nin 210 LI:2048338.1:2000SEP08 541 591 forward 1 TM Nin 210 LI:2048338.1:2000SEP08 281 358 forward 2 TM Nin 211 U:1185203.8:2000SEP08 73 135 forward 1 TM Nout 211 LI:1185203.8:2000SEP08 148 210 forward 1 TM Nout 211 LI:1185203.8:2000SEP08 226 294 forward 1 TM Nout 212 U:021770.3:2000SEP08 593 673 forward 2 TM Nout 212 LI:021770.3:2000SEP08 348 434 forward 3 TM Nin 212 LI:021770.3:2000SEP08 462 539 forward 3 TM Nin 212 LI:021770.3:2000SEP08 564 641 forward 3 TM Nin .212 U:021770.3:2000SEP08 861 944 forward 3 TM Nin 213 LI: 1185841.1.2000SEP08 1132 1182 forward 1 TM Nout 213 U: 1185841.1:2000SEP08 2434 2520 forward 1 TM Nout 213 U: 1185841.1:2000SEP08 965 1030 forward 2 TM Nin 213 U: 1185841.1:2000SEP08 2381 2437 forward 2 TM Nin 214 U:1181710.1:2000SEP08 221 307 forward 2 TM Nout 215 LI:2048959.1:2000SEP08 262 318 forward 1 TM Nout 216 LI:798494.1:2000SEP08 595 657 forward 1 TM Nout 216 U:798494.1:2000SEP08 670 732 forward 1 TM Nout 216 U:798494.1:2000SEP08 215 268 forward 2 TM Nout 216 LI:798494.1:2000SEP08 12 62 forward 3 TM Nout 216 LI:798494.1:2000SEP08 60 113 forward 3 TM Nout 217 U:2049223.1:2000SEP08 436 507 forward 1 TM , Nin 217 LI:2049223.1:2000SEP08 416 484 forward 2 TM Nout 218 LI:1177833.1:2000SEP08 712 798 forward 1 TM Nin 219 LI:2049267.1:2000SEP08 215 289 forward 2 TM Nout TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topology 219 LI:2049267.1:2000SEP08 240 323 forward 3 TM out 220 LI:1165939.1 :2000SEP08 554 640 forward 2 TM 221 U:1170958.1:2000SEP08 326 376 forward 2 TM N out 222 LI:1089827.1.2000SEP08 1507 1584 forward 1 TM N in 223 U:792112.1:2000SEP08 818 892 forward 2 TM N in 223 U:792112.1:2000SEP08 9 86 forward 3 TM 223 LI:792112.1:2000SEP08 669 755 forward 3 TM 223 U:792112.1:2000SEP08 783 860 forward 3 TM 224 LI:282219.2:2000SEP08 661 732 forward 1 TM N out 224 U:282219.2:2000SEP08 491 577 forward 2 TM N in 224 U:282219.2:2000SEP08 659 745 forward 2 TM N in 224 U:282219.2:2000SEP08 408 458 forward 3 TM N in 225 LI:1088010.2:2000SEP08 289 375 forward 1 TM N in 225 LI:1088010.2:2000SEP08 716 793 forward 2 TM N in 225 LI:1088010.2:2000SEP08 1229 1315 forward 2 TM N in 225 LI:1088010.2:2000SEP08 903 980 forward 3 TM N out 225 LI:1088010.2:2000SEP08 1002 1088 forward 3 TM N out 225 LI:1088010.2:2000SEP08 1 185 1247 forward 3 TM N out 225 LI:1088010.2:2000SEP08 1272 1334 forward 3 TM N out 226 Ll:l 165276.1 :2000SEP08 301 363 forward 1 TM N in 226 LI:1165276.1 :2000SEP08 882 968 forward 3 TM N out 227 LI:1169524.2:2000SEP08 623 709 forward 2 TM 227 U:1169524.2:2000SEP08 713 778 forward 2 TM 227 U:1169524.2:2000SEP08 842 928 forward 2 TM 228 LI:1180255.1 :2000SEP08 731 784 forward 2 TM N in 228 LI:1180255.1 :2000SEP08 872 931 forward 2 TM N in 228 U:1180255.1:2000SEP08 1 199 1285 forward 2 TM N in 229 LI:1091 03.1:2000SEP08 454 540 forward 1 TM N out 230 LI:1169219.1:2000SEP08 496 582 forward 1 TM N in 230 LI:1169219.1:2000SEP08 509 595 forward 2 TM N out 230 U:1169219.1:2000SEP08 495 581 forward 3 TM 231 LI:2050313.1:2000SEP08 2605 2664 forward 1 TM N in 231 LI:2050313.1:2000SEP08 3229 3315 forward 1 TM N in 231 LI:2050313.1:2000SEP08 3412 3498 forward 1 TM N in ' 231 LI:2050313.1:2000SEP08 1886 1954 forward 2 TM N in 231 LI:2050313.1:2000SEP08 2654 2731 forward 2 TM N in 231 LI:2050313.1:2000SEP08 2924 2986 forward 2 TM N in 231 LI:2050313.1:2000SEP08 3029 3091 forward 2 TM N in 231 LI:2050313.1:2000SEP08 3482 3568 forward 2 TM N in 231 U:2050313.1:2000SEP08 855 920 forward 3 TM N out 231 LI:2050313.1:2000SEP08 2445 2531 forward 3 TM N out 231 LI:2050313.1:2000SEP08 2646 2708 forward 3 TM N out 231 U:2050313.1:2000SEP08 2721 2783 forward 3 TM N out 231 U:2050313.1:2000SEP08 31 14 3170 forward 3 TM N out 231 U:2050313.1:2000SEP08 3504 3590 forward 3 TM N out 232 Ll:209351.3:2000SEP08 586 645 forward 1 TM N in 232 LI:209351.3:2000SEP08 1945 2025 forward 1 TM N in 232 Ll:209351.3:2000SEP08 353 415 forward 2 TM 232 Ll:209351.3:2000SEP08 665 718 forward 2 TM 232 Ll:209351.3:2000SEP08 1313 1387 forward 2 TM 90 O) o .Z .Z . CZ Q D Q TJ c _c c c c 3 3 3 3 3 3 C 3 C C C C C C C C C 3 3 3 3 3 3 3 C C C 3 3 3 o z z z z z z O O O O O O— O — — — — — — — — — O O O O O O O — — " O O O o. z z z z z z z z z z z o H U f αo r w α. σ E f o r wα Σ S S -≥ -≥ Σ -≥ -≥ -≥ -> -> 2 o Q f oα r w f o r wα ■— CM CN CN CN CO CO CO CO CO CJ — O r- r- c co — ■ σ Ό τ> "o Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό Ό σ σ o σ o o o o σ o o o σ o σ σ σ σ o σ σ σ o o σ σ o σ o o o o o σ σ o σ σ o σ σ o o o σ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o £v2>2«2 0 >2 0 0 0 0 0 0 0 0 0 0 0 0 O . — o -o !3 ^ 2' <Ω ^ rø r^ S m ^ L> rN. co ^ S co o oo N. r- cN < oo J Xj ( 3 r- ig Q Nt o O CN U-; co J J £ -o o o 5 o ^r t o rN. N θ i . ^ | N^ ^ ^ u ( W CO C r N , ^ „ w lO C ^ c ^ M ^ | > o ^ 00 θ 'N CO S u -o "Nt . _ cj u r-N J cj oo -Nt oo r- oo c o O _ CM CN CN CM CN CN CO CJ CJ CO C Nt 'Nt 'Nt 'Nt -0 -θ Nθ -0 J r N . |-v [v. r N , r N . CO CO O O O O O O O O r- CM CO cO CJ CO L j c co cj c c cj cj cj co co co -O co c co co cj cj cj co co co co co co co c cj co o — CM CN CN CN CN CN CN CN CN CN CN CN CN CN CM CN CN CN CN CN CN CN CN CN CN CN CN CN CN f CM CN CN CN CN CN CN t 5.5: -: -ϊ i. t , ϊ 5t 5 O TABLE 4 SEQ ID NO: Template ID Start Stop Frame Domain Topology 244 LI 1177823.2:2000SEP08 311 370 forward 2 TM Nin 245 LI 1174279.1:2000SEP08 634 720 forward 1 TM Nout 245 LI 1174279.1:2000SEP08 724 789 forward 1 TM Nout 246 LI 1178411.1:2000SEP08 1357 1443 forward 1 TM 246 LI 1178411.1:2000SEP08 1290 1376 forward 3 TM Nin 246 LI 1178411.1.2000SEP08 1419 1472 forward 3 TM Nin 247 LI 1182739.1.2000SEP08 853 939 forward 1 TM Nin 247 LI 1182739.1.2000SEP08 1900 1986 forward 1 TM Nin 247 LI 1182739.1:2000SEP08 2131 2217 forward 1 TM Nin 247 LI 1182739.1:2000SEP08 2341 2403 forward 1 TM Nin 247 LI 1182739.1.20005EP08 2446 2508 forward 1 TM Nin 247 LI 1182739.1.2000SEP08 803 859 forward 2 TM Nin 247 LI 1182739.1.20O0SEP08 1268 1351 forward 2 TM Nin 247 LI 1182739.1.2000SEP08 1445 1513 forward 2 TM Nin 247 LI 1182739.1.2000SEP08 1796 1882 forward 2 TM Nin 247 LI 1182739.1:2000SEP08 2090 2176 forward 2 TM Nin 247 LI 1182739.1.2000SEP08 2267 2323 forward 2 TM Nin 247 LI 1182739.1.2000SEP08 2363 2449 forward 2 TM Nin 247 LI 1182739.1.2000SEP08 1182 1244 forward 3 TM Nout 247 LI 1182739.1:2000SEP08 1254 1316 forward 3 TM Nout 247 LI 1182739.1:2000SEP08 2100 2156 forward 3 TM Nout 247 LI 1182739.1.2000SEP08 2301 2387 forward 3 TM Nout 248 LI:234937.4:2000SEP08 301 387 forward 1 TM Nout 249 LI 1170660.1.2000SEP08 604 690 forward 1 TM Nin 249 LI 1170660.1.2000SEP08 757 843 forward 1 TM Nin 249 LI 1170660.1.2000SEP08 937 990 forward 1 TM Nin 249 LI 1170660.1.2000SEP08 llll 1179 forward 1 TM Nin 249 LI 1170660.1:2000SEP08 512 583 forward 2 TM 249 LI 1170660.1:2000SEP08 911 973 forward 2 TM 249 LI 1170660.1:2000SEP08 986 1048 forward 2 TM 249 LI 1170660.1:2000SEP08 252 323 forward 3 TM Nout 249 LI 1170660.1.2000SEP08 591 677 forward 3 TM Nout 249 LI 1170660.1:2000SEP08 774 860 forward 3 TM Nout 250 LI 1144409.1:2000SEP08 25 81 forward 1 TM Nout 250 LI 1144409.1:2000SEP08 1708 1782 forward 1 TM Nout 250 LI 1144409.1.2000SEP08 2281 2367 forward 1 TM Nout 250 LI 1144409.1:2000SEP08 1658 1744 forward 2 TM Nin 250 LI 1144409.1:2000SEP08 1880 1927 forward 2 TM Nin 250 LI 1144409.1:2000SEP08 2294 2380 forward 2 TM Nin 250 LI 1144409.1:2000SEP08 1614 1697 forward 3 TM Nin 250 U 1144409.1:2000SEP08 2217 2303 forward 3 TM Nin 251 LI 246290.10:2000SEP08 248 304 forward 2 TM Nout 251 LI 246290.10:2000SEP08 641 727 forward 2 TM Nout 251 LI 246290.10:2000SEP08 3 89 forward 3 TM Nout 252 :280034.1:2000SEP08 279 365 forward 3 TM Nout TABLE 5 SEQ ID NO: Template ID Component ID Start Stop LG: 150318.1 :2000SEP08 482540R6 1 350 LG:150318.1 :2000SEP08 482540H1 1 238 LG:150318.1 :2000SEP08 6021134T8 126 531 LG:150318.1 :2000SEP08 6021134R8 126 537 LG:150318.1 :2000SEP08 6021134H1 126 629 2 LG:022529.1 :2000SEP08 7593029H1 1 521 2 LG:022529.1 :2000SEP08 g1645695 112 517 2 LG:022529.1 :2000SEP08 2160267H1 275 514 2 LG:022529.1 :2000SEP08 5284828H1 309 583 2 LG:022529.1 :2000SEP08 g1880347 313 601 2 LG:022529.1 :2000SEP08 7352207H1 330 707 2 LG:022529.1 :2000SEP08 6863346H1 339 830 2 LG:022529.1 :2000SEP08 3351341 HI 423 681 2 LG:022529.1 :2000SEP08 077299H1 432 632 2 LG:022529.1 :2000SEP08 078146H1 438 646 2 LG:022529.1 :2000SEP08 3801790F6 523 1030 2 LG:022529.1 :2000SEP08 3801790H1 523 823 2 LG:022529.1 :2000SEP08 3769238F6 523 1043 2 LG:022529.1 :2000SEP08 3802590H1 524 810 2 LG:022529.1 :2000SEP08 6217218H1 549 1039 2 LG:022529.1 :2000SEP08 g5743872 664 1137 2 LG:022529.1 :2000SEP08 g3051534 685 1047 2 LG:022529.1 :2000SEP08 g4195758 789 1045 3 LG:352559.1 :2000SEP08 6453567H1 1 503 3 LG:352559.1 :2000SEP08 4052122H1 185 457 3 LG:352559.1 :2000SEP08 4052122F7 185 636 3 LG:352559.1 :2000SEP08 g3897399 255 371 4 LG:175223.1 :2000SEP08 3081155F6 1 417 4 LG:175223.1 :2000SEP08 3081155H1 2 315 4 LG:175223.1 :2000SEP08 3081155T6 31 465 4 LG:175223.1 :2000SEP08 g1648354 58 457 4 LG: 175223.1 :2000SEP08 5800009H1 99 507 5 LG:476989.1 :2000SEP08 6874941 HI 1 169 5 LG:476989.1 :2000SEP08 6874955H1 1 204 5 LG:476989.1 :2000SEP08 g4393499 51 432 5 LG:476989.1 :2000SEP08 g4190810 96 432 6 LG:253268.7:2000SEP08 6772515H1 607 1083 6 LG:253268.7:2000SEP08 g5526194 596 941 6 LG:253268.7:2000SEP08 g4729197 690 941 6 LG:253268.7:2000SEP08 g5809986 501 941 6 LG:253268.7:2000SEP08 g2540947 535 937 6 LG:253268.7:2000SEP08 g922062 586 935 6 LG:253268.7:2000SEP08 6772515J1 454 961 6 LG:253268.7:2000SEP08 2535554F6 493 929 6 LG:253268.7:2000SEP08 g4392225 520 923 6 LG:253268.7:2000SEP08 g3424830 561 923 6 LG:253268.7:2000SEP08 g4533991 464 923 6 LG:253268.7:2000SEP08 g885146 693 914 6 LG:253268.7:2000SEP08 g917418 564 914 6 LG:253268.7:2000SEP08 g888754 605 914 US 90 CM t~- CM O Ω- CO CN i- 'Nt 'Nt c r- 'N r . r- rN. -o rN. 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[v. rv. rv. r v . oo oo co oo co co oo co oo oo o o o o o o o o o o G LU O O TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 9 LG:475404.1: 2000SEP08 3206542H1 25 202 9 LG:475404.1: 2000SEP08 4663964H1 37 289 9 LG:475404.1: 2000SEP08 7652675J1 47 172 9 LG:475404.1: 2000SEP08 gl807165 81 278 9 LG:475404.1: 2000SEP08 g2401959 129 486 9 LG:475404.1: 2000SEP08 3614680H1 155 272 9 LG:475404.1: 2000SEP08 g5101146 180 486 10 LG:1384132.1 .2000SEP08 5754964H1 1 453 10 LG: 1384132.1 • 2000SEP08 g5366771 73 480 10 LG:1384132.1 • 200OSEP08 3246016H1 198 446 11 LG:410804.18 :2000SEP08 3270045H1 1 252 12 LG:1082306.1 • 2000SEP08 2590822H1 60 224 12 LG: 1082306.1 2000SEP08 2875044H1 13 269 12 LG: 1082306.1 .2000SEP08 5944268H1 12 288 12 LG:1082306.1 2000SEP08 908479H1 39 241 12 LG: 1082306.1 2000SEP08 2972368F6 1 586 12 LG: 1082306.1 2000SEP08 2972368H1 1 292 12 LG:1082306.1 2000SEP08 1831460H1 393 656 12 LG:1082306.1 2000SEP08 g2270170 247 638 12 LG:1082306.1 2000SEP08 1732781 HI 118 297 12 LG:1082306.1 2000SEP08 4136083H1 590 657 12 LG:1082306.1 2000SEP08 5152624H1 463 723 12 LG:1082306.1 2000SEP08 2634451 HI 434 685 13 LG:233814.4:2000SEP08 6907331Jl 757 1055 13 LG:233814.4:200OSEP08 7435089H1 1 580 13 LG:233814.4:2000SEP08 7579295H1 475 927 13 LG:233814.4:2000SEP08 2818676H1 511 729 13 LG:233814.4:2000SEP08 1943949H1 632 863 13 LG:233814.4:2000SEP08 7403021 HI 703 1146 14 LG:977478.5:2000SEP08 7087230H1 1 549 14 LG:977478.5:2000SEP08 5525655H2 50 293 14 LG:977478.5:2000SEP08 7198649H1 74 395 14 LG:977478.5:2000SEP08 3218939H1 164 284 14 LG:977478.5:2000SEP08 2137947T7 182 714 14 LG:977478.5:2000SEP08 2137242H1 274 541 14 LG:977478.5:2000SEP08 2970423T6 312 783 14 LG:977478.5:2000SEP08 2970423F6 319 720 14 LG:977478.5:2000SEP08 2970423H2 319 633 14 LG:977478.5:2000SEP08 g6464000 464 821 14 LG:977478.5:2000SEP08 974781HI 501 774 14 LG:977478.5:2000SEP08 g6044798 530 821 15 LG:025931.1:2000SEP08 6075128F6 1 524 15 LG:025931.1:2000SEP08 7002695H1 272 846 15 LG:025931.1:2000SEP08 1949002R6 435 707 15 LG:025931.1:2000SEP08 1949002H1 435 692 15 LG:025931.1:2000SEP08 g6711855 473 929 15 LG:025931.1:2000SEP08 3348048H1 497 748 15 LG:025931.1:2000SEP08 7382758H1 573 962 15 LG:025931.1:2000SEP08 5844022H1 224 474 15 LG:025931.1: 2000SEP08 5844022F6 223 614 TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 15 LG.025931.1 2000SEP08 6075128H1 1 185 16 LG:885368.1 2000SEP08 5909782T7 1 494 16 LG:885368.1 2000SEP08 6269652H1 1 415 16 LG:885368.1 2000SEP08 5909782H1 1 306 16 LG:885368.1 2000SEP08 5909782F7 1 578 16 LG:885368.1 2000SEP08 6269652F8 1 682 16 LG:885368.1 2000SEP08 5909795H1 1 305 16 LG:885368.1 2000SEP08 5909895H1 1 133 16 LG:885368.1 2000SEP08 6269652T8 99 618 16 LG:885368.1 2000SEP08 4982679T6 377 550 17 LG 1054900.1 :2000SEP08 2327449H1 15 248 17 LG 1054900.1 :2000SEP08 2327457T6 1 364 17 LG 1054900.1 :2000SEP08 2327449T6 1 288 17 LG 1054900.1 :2000SEP08 2327449R6 13 408 17 LG 1054900.1 :2000SEP08 2327457R6 13 402 17 LG 1054900.1 :2000SEP08 6537441 HI 147 499 17 LG 1054900.1 :2000SEP08 5108773H1 196 254 18 LG:995186.2:2000SEP08 5056145F6 1 549 18 LG:995186.2:2000SEP08 6061051F8 169 669 19 LG:435048.23:2000SEP08 6867561 HI 1 461 19 LG:435048.23:2000SEP08 3531553H1 53 327 20 LG:954859.1 2000SEP08 gόl96726 233 638 20 LG:954859.1 2000SEP08 g2344451 154 637 20 LG:954859.1 2000SEP08 3814110T6 148 602 20 LG:954859.1 2000SEP08 3815093T6 146 591 20 LG:954859.1 2000SEP08 6475045H1 1 548 20 LG:954859.1 2000SEP08 6413028H1 1 373 21 LG:364370.1 2000SEP08 6798273H1 1 497 21 LG:364370.1 200OSEP08 6798273F8 1 574 21 LG:364370.1 2000SEP08 4431872H1 3 82 21 LG:364370.1 2000SEP08 6792402T8 9 592 21 LG:364370.1 2000SEP08 6792402F8 9 705 21 LG:364370.1: 2000SEP08 6792402H1 9 500 21 LG:364370.1: 2000SEP08 6798273T8 362 543 22 LG:1098789.1:2000SEP08 3537002T6 1 461 23 LG:201540.2:2000SEP08 5764854H1 2 545 23 LG:201540.2:2000SEP08 4664068F6 1 316 23 LG:201540.2:2000SEP08 4664068H1 2 237 23 LG:201540.2:2000SEP08 5968685H1 26 592 23 LG:201540.2:2000SEP08 3160094H1 98 362 23 LG:201540.2:2000SEP08 652754H1 101 353 23 LG:201540.2:2000SEP08 6788325H1 118 489 23 LG:201540.2:2000SEP08 g1950834 690 910 23 LG:201540.2:2000SEP08 2739044F6 689 1171 23 LG:201540.2:2000SEP08 6829490J1 703 1219 23 LG:201540.2:2000SEP08 2739044H1 690 924 23 LG:201540.2:2000SEP08 7328749H1 733 1261 23 LG:201540.2:2000SEP08 6829490H1 712 1219 23 LG:201540.2:2000SEP08 2857116H1 777 1049 23 LG :201540.2: 2000SEP08 g769612 173 528 TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 23 LG:201540.2:2000SEP08 6490433H1 287 779 23 LG:201540.2:2000SEP08 5096074T6 604 1006 23 LG:201540.2:2000SEP08 7262169H1 642 1193 23 LG:201540.2:2000SEP08 6310909H1 308 887 23 LG:201540.2:2000SEP08 5096074H2 347 523 23 LG:201540.2:2000SEP08 5096074F6 347 703 23 LG:201540.2:2000SEP08 7701612J1 518 1093 23 LG:201540.2:2000SEP08 4053114H1 100 386 23 LG:201540.2:2000SEP08 4319192H1 131 397 23 LG:201540.2:2000SEP08 3414632H1 132 252 23 LG:201540.2:2000SEP08 7200283H1 142 699 24 LG 1077357.1.2000SEP08 6245903F8 120 547 24 LG 1077357.1.2000SEP08 6245903H1 121 532 24 LG 1077357.1 :2000SEP08 g3250058 1 408 24 LG 1077357.1.2000SEP08 g3694145 26 408 24 LG 1077357.1.2000SEP08 g4333202 140 407 24 LG 1077357.1:2000SEP08 6779728J1 1 370 25 LG 1048846.4:2000SEP08 5433043T9 1 476 25 LG 1048846.4:2000SEP08 3256037H1 191 435 25 LG 1048846.4:2000SEP08 3256037R6 191 354 25 LG 1048846.4:2000SEP08 3207387H1 213 461 25 LG 1048846.4:2000SEP08 4316787H1 247 532 25 LG 1048846.4:2000SEP08 4630864T8 263 483 26 LG.336685.1: 2000SEP08 g1422427 85 461 26 LG.336685.1: 2000SEP08 3167506H1 1 292 26 LG:336685.1: 2000SEP08 g3751213 82 477 26 LG.336685.1: 2000SEP08 g3039675 93 477 26 LG:336685.1: 2000SEP08 7612160J1 631 1172 26 LG:336685.1: 2000SEP08 7585885H2 458 1146 26 LG:336685.1: 2000SEP08 7330357H1 428 965 26 LG:336685.1: 2000SEP08 7612160H1 246 869 26 LG:336685.1: 2000SEP08 g3844561 389 808 26 LG:336685.1: 2000SEP08 g2702908 347 805 26 LG:336685.1: 2000SEP08 g1422428 441 805 27 LG:1076253.1 :2000SEP08 5677775H1 24 273 27 LG:1076253.1 :2000SEP08 828479H1 617 874 27 LG:1076253.1 :2000SEP08 5677775F6 24 610 27 LG:1076253.1 :2000SEP08 7392292H1 1 584 27 LG: 1076253.1 :2000SEP08 4896201 F8 298 724 27 LG: 1076253.1 :2000SEP08 4896201 HI 298 566 27 LG: 1076253.1 :2000SEP08 7933083H1 389 898 27 LG: 1076253.1 :2000SEP08 2717909H1 429 684 27 LG: 1076253.1 :2000SEP08 392443R1 585 1112 27 LG:1076253.1 :2000SEP08 4896201T8 826 1314 27 LG: 1076253.1 :2000SEP08 4896201T9 872 1357 27 LG: 1076253.1 :2000SEP08 3989646T6 1029 1418 27 LG: 1076253.1 :2000SEP08 2779195T6 1078 1411 27 LG:1076253.1 :2000SEP08 3989646R6 354 748 27 LG:1076253.1 :2000SEP08 3989646H1 354 512 28 LG 1400601.2 :2000SEP08 6967393H1 1 600 TABLE 5 SEQ ID NO Template ID Component ID Start Stop 29 LG 107909232000SEP08 6002889F8 1 660 29 LG 107909232000SEP08 6002889T8 104 612 30 LG 108606412000SEP08 456122R6 6 395 30 LG 10860641 ■ 2000SEP08 5941956H1 8 286 30 LG 108606412000SEP08 4727660F6 1 542 30 LG 1086064.1 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30 LG 10860641 ^OOOSEPOβ 460283H1 6 240 30 LG 1086064.1.2000SEP08 3735303H1 22 340 30 LG 1086064.1 :2000SEP08 1798649H1 6 280 30 LG 1086064.1 :2000SEP08 1698730H1 165 359 31 LG 140060812000SEP08 4399221 HI 25 234 31 LG 1400608.1 :2000SEP08 5120882F6 1 353 31 LG 1400608.1:2000SEP08 014670H1 7 288 31 LG 140060812000SEP08 5378061 HI 133 391 31 LG 1400608.1.2000SEP08 5378061 F6 133 591 31 LG 1400608.1 :2000SEP08 g4265183 180 641 31 LG 1400608.1.2000SEP08 4881456H1 274 353 31 LG 14006081 '2000SEP08 2882961 HI 13 272 31 LG 14006081.2000SEP08 5120882H1 1 265 31 LG 1400608.1 :2000SEP08 1899877H1 41 265 31 LG 1400608.1 :2000SEP08 gl959316 41 357 32 LG-39927552000SEP08 2054642H1 354 539 32 LG:399275.5:2000SEP08 7688287H1 1 410 32 LG:399275.5:2000SEP08 1561014H1 169 351 32 LG 399275.5-2000SEP08 7688287J1 192 657 33 LG.293943.1.2000SEP08 7102403R8 1 647 33 LG:293943.1 :2000SEP08 g2007300 100 453 LJ-CM rv. rv. o o -o -o o co rv. vt o o co cj CN 'g; vt r- rv. rv. r— -Vt <— CN co rv O CO CO CM O vt 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Ji- J^- -- t-. J^ --- --- o o o o o 8 en en en en 8 tN. tN. t-. -- 4 O en en en c_n cn cn en en en en cn en o o o o o o o o o o ^ r NJ NJ NJ NJ N j t j k> k) Nj " — ■ " — ' ^ ^ ^ — ' — ' - . f N, J N NJ N N r r ( J r N CΛ O 4-- ^ -vl o o _ o ^ r o o o- - *- e o o 0 0 --- o NJ θ θ » ^ ^ c» N j e N ^ oo oo co N j e> o en en en e ^ o o o oo o -^ f B Nj O o e e oo NJ O o oo e Q o o Cn ° O , NJ NJ Cn CO — ' ffl ϋl O -O K ^ o- crι oι (fl α [ji M M M _- « M _ M -- -- ^ n C'i Ni c- θ' θ> ι (> _- _, g g o ω ω ω o θ Nj C» o c» - N ω g o __ J - 0 g ω o , t , 0 ω o ■δ °: ^ » r f v v i » w ω _ ϋι 90 Q_ CN CJ O CO Cθ rv. CJ |v. O rv. ιv, r -- σ ( θ u co st cθ r- o o o st co co o o -o ιv, o rv, CN θ rv co uj rv, oo c rv. cM t t cj co o uj θ r— Q St r- cO ^ _ O _ c O _ UJ st cO st OO CJ O CM st O CN O st c rv. O O OO CJ CN '— O CO CO O O OO UJ O UJ O CJ UJ C rv cO O OO CN co <) O -) <ι -) <) -) -) <) '- c. 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C. q ' 0 '0 '0 N π W 'C '- n N O . r- 0 ' ^ O -— CN CN CN CN CN CN C CJ C C CO st st UJ UJ UJ UJ rv. rv. oθ OO OO O O O O CJ CJ CO C C CO c c st st ι CO O c^ r- r- r- r- r- r- r- r- r- r- r- r- ■— r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- CN CN CN CN CN CM CM CM CN CN CM CM CN CO OO OO CO OO OO OO CO OO CO CO CO CO ∞ o_^oooooopoooooooooo C CO CO C C C CO ό z o Q O O O O O O O O O O o o o o o o o o o o o o o rv. |v. rv, rv, rv, — UJ UJ UJ UJ UJ -O UJ UJ UJ UJ -8 o UJoUJoUJoL oUJ UoJoUJ -o-J UoJ oUJ 8 o UJ UJ UJ o UJ oJ oJ oUJ oJ oJ UJ UJ UJ UJ UJ UJ UJ J UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ o G uu o 90 *o o ^ CN r- o O p st OO st cO CO CM O CO O CN "— CO O CJ St st CM CN rv. CM Iv. CJ CN O OO rv. rv --. O . O _ OO _ C . N I— uj . u . u . cj cj st c o _ rv rv co rv. 0 <) N r- ) iδ ffl N O ) C. O W '- ιO -> '0 -' & ιO O '0 (0 ) r. ^ C O '0 -) C. O t S ι0 3 l> ^ r- 0> ^ C. lO C. I ) O O N OO N N '- fe rN. CN J C C st UJ UJ ( st O UJ O CO CN CN C C C rN. CN CO θ rN. O CO O UJ ^ C st st -O UJ r— CJ CJ CN CM CM CO St st st r- ^t H U α. σ 3 c _J u r-v ,— CN o sf — f CO C t l n ^- ) r-v |-v O O O CO O co fv / v O O CM CM '- r- CO O O r _ __ C CN | C St r- r- ^ J st U J r- ^ ^ rv. rv. O O rv. r- r- r- r- O CM CN CM n ^ ^ st j o o rv, ■— CN CM CJ " C O C O Ξ 83 & . CO CO OO CO CO CO CO CO CO OO CO Gp CO OO OO CO OO --. --- --- l_L -L CL CL CL CL θL Q- co co co co co co co co co O O O CN CN CN CN CN CN CM CM CM lO UJ UJ - -O - UJ -O -O UJ UJ -O UJ UJ c O z: o Q r v . rv. rv r v . rv rv. rv. | v . rv. co oo oo co co o o o o o o o o o o o O O O O r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ O O O O o o o o o o o o o o o o o o o o o o o o o o o o σ O TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 61 LG:1135213.1:2000SEP08 g4326525 1 141 61 LG:1135213.1:2000SEP08 g2525795 28 236 62 LG:267762.1:2000SEP08 3941090F8 1 334 62 LG:267762.1:2000SEP08 1704531 HI 153 292 62 LG:267762.1:2000SEP08 7658244J1 267 830 62 LG:267762.1:2000SEP08 5674936F6 283 888 62 LG:267762.1:2000SEP08 5674936H1 283 545 62 LG:267762.1:2000SEP08 5785070H1 482 768 62 LG:267762.1:2000SEP08 2831361 HI 514 783 62 LG:267762.1:2000SEP08 g1523057 527 994 62 LG:267762.1:2000SEP08 6244881 HI 600 677 62 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E O J- J- O O' O M -' W Oi O -O M O W O OO C. i-. *- o — o t-ι vj _- o- c e j o — ' Co o co cn o u TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 74 LG:197614.1 :20∞SEP08 7650036H2 2417 2975 74 LG:197614.1:2000SEP08 7156980H1 938 1507 74 LG:197614.1 :2000SEP08 7663421 HI 1134 1649 74 LG:197614.1:2000SEP08 7650036J2 1157 1772 74 LG:197614.1:2000SEP08 7359954H1 1252 1784 74 LG:197614.1:2000SEP08 7621265J1 1262 1833 74 LG:197614.1:2000SEP08 5732485H1 1126 1318 74 LG:197614.1 :2000SEP08 7080048H1 1640 2223 74 LG:197614.1:2000SEP08 6485720H1 1880 2304 74 LG:197614.1:2000SEP08 6485720F9 1926 2075 74 LG:197614.1 :2000SEP08 081459H1 1973 2232 74 LG:197614.1:2000SEP08 7663421Jl 2044 2608 74 LG:197614.1 :2000SEP08 g3423345 3018 3467 74 LG:197614.1 :2000SEP08 g5590054 3020 3467 74 LG:1 7614.1 :2000SEP08 g4111681 3027 3467 74 LG:197614.1:2000SEP08 2617018H2 3029 3265 74 LG:197614.1 :2000SEP08 3815347H1 3033 3315 74 LG:197614.1 :2000SEP08 g777251 3046 3330 74 LG:197614.1:2000SEP08 g2817792 3086 3475 74 LG:197614.1:2000SEP08 4897664H1 3826 3991 74 LG:1 7614.1 :2000SEP08 4896259H1 3849 4001 74 LG:197614.1:2000SEP08 gl212198 3850 4178 74 LG:197614.1:2000SEP08 g1748459 3880 3967 74 LG:197614.1:2000SEP08 5063386H1 3886 4001 74 LG:197614.1 :2000SEP08 1491069H1 3900 4105 74 LG:197614.1 :2000SEP08 1491069F6 3900 4001 74 LG:197614.1:2000SEP08 g896855 4022 4245 74 LG:197614.1:2000SEP08 g4901112 4022 4378 74 LG:197614.1 :2000SEP08 g4990162 4025 4297 74 LG:197614.1:2000SEP08 gόό99628 4025 4483 74 LG:197614.1:200OSEP08 180009T6 4072 4569 74 LG:197614.1:2000SEP08 1491069T6 4075 4576 74 LG:197614.1 :2000SEP08 6208837H1 4088 4388 74 LG:197614.1 :200OSEP08 7355849H1 4097 4587 74 LG:197614.1:2000SEP08 2588654H1 2874 3132 74 LG:1 7614.1 :2000SEP08 426115R6 2948 3453 74 LG:197614.1:2000SEP08 g1492260 2879 3120 74 LG:197614.1:2000SEP08 3873481 HI 2937 3214 74 LG:197614.1 :2000SEP08 425031HI 2948 3210 75 LG:378428.1 :2000SEP08 6910888F8 560 708 75 LG:378428.1 :2000SEP08 7379444H1 36 599 75 LG:378428.1 :2000SEP08 6816543H1 185 640 75 LG:378428.1 :2000SEP08 6816543F8 285 641 75 LG:378428.1 :2000SEP08 7429391 HI 439 956 75 LG:378428.1 :2000SEP08 6816543R8 1 644 75 LG:378428.1 :2000SEP08 7379418H1 36 609 75 LG:378428.1 :2000SEP08 6910888J1 768 1376 75 LG:378428.1 :2000SEP08 6910888R8 773 1449 75 LG:378428.1:2000SEP08 6044422H1 726 1023 75 LG:378428.1 :2000SEP08 6044422F8 725 1341 10 J N M N N N N N N M NI N N M N N M M M M M N N N N M N M N N N N N N N M N N N NJ N M N N N M M N vj vj — o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o oi cn cn en en en cn en en en en en en en en en en en en O 0 øøøøøøøøøøøøøøøøøø rό r rNJ K- r Nj rNJ NJ r J NJ rJ NJ M CB OO OO OO OO CJO OO OO OO α α CB OO OO α O CXI OO . O O O O O O O O O O O O O O O O O O ^ 1 ωωOw0uωw0uwwwω0ωOωωωOω0w0ω -ii O O O O O O O O O O -g r r r r NJ r r ro NJ rό ro r rNJ r r o o o o o o o o o o o o o o o ό o ό C o OoOOoOoOoOoOOO O OOO (Λ (Λ <Λ C ω cnowoc)oCΛoOoO M (Λ «oO co)ocnowowoO woO — (Λ D ) lm)mlmImIm)m)mIm)mTI )mImImTIm2m-Om O O TI 00O00O00OCX3 00O00O00OC»OO0O00O00OC»O00OC»OCJ0CCDJ0OC»OC» > en eo NJ KJ — ■ _, O O p vj en o co oo s C J-- C- J-. — ' O — - to — c r rN - J ^ co ^ ^ ^ o ^o en o o o o NJ en tN_ r co en en cπ en -+ o o o o — o oo o P o oo o o o — ro o o fc- — ~ ro o & oi & 5 Q ro — oi o o t-- — i o o " ro e ' n e ^ n J --. — 5 — o o o o — • — > ? roi Ti NJ NJ Co Co — Co o NJ . i. O Co O Ol O O O O N M O M J_ o o — °° . o. fj jv 'N 'Nj i iNJ — NJ to — ' ro ro — ■ — ■ — • — • — ■ — ■ — ■ — ■ — • — ■ — ■ — ■ — ■ — ■ — ■ , <-__ - N N r rNj r N N — ■ — ■ — ■ — ■ ■ — ■ — ■ — ■ to to — ■ co K K ft w M ^ M ) M M ) M w w α ϋι ) » (> j- θ' t oo N ^ o o ^ S S ^ ω ω ^ co fc o o ^ « cn N θ « ^ (» oo o o w * N y ^ oo co ^ W N » oo oo ^ & o t t ^ N 5 ^ α M rι ^ N S _ o >o -o -' N θ cιo o <) o o ϋι -. Nj » Nj to co oo o. u β ^ -' -' Ui NI Oι -' -O' -' Nl O O C- Oι C>ι lO b M OJ 5 ™ 00 ' O>" n ι N> l J J f --- 1 " - N"C"» 'C.- i''- O- t'> 0 —0 O — b - O - - , N - { -- -0 - -' O _ W. . I.»- 0_0- -- O TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 77 LG:389870.1 2O00SEP08 7065623H1 534 764 77 LG:389870.1 2000SEP08 7191788H2 368 640 77 LG:389870.1 2000SEP08 7354238H1 129 677 IT LG:389870.1 2000SEP08 g2740716 1 454 11 LG:389870.1 2000SEP08 g4389793 1 454 11 LG:389870.1 2000SEP08 7459406H1 769 1222 11 LG:389870.1 2000SEP08 4030167H1 620 850 11 LG:389870.1 2000SEP08 7583301 HI 710 1249 78 LG:1387485.6:2000SEP08 1259442F6 727 1286 78 LG:1387485.6:2000SEP08 575641HI 210 423 78 LG:1387485.6:2000SEP08 2695041 HI 441 744 78 LG: 1387485.6:2000SEP08 5394337H1 572 857 78 LG:1387485.6:2000SEP08 4773576H1 617 849 78 LG:1387485.6:2000SEP08 1722977H1 707 964 78 LG:1387485.6:2000SEP08 1722977F6 707 1113 78 LG:1387485.6:2000SEP08 1259442H1 726 966 78 LG:1387485.6:2000SEP08 5004203H1 894 1024 78 LG:1387485.6:2000SEP08 4545090H1 897 1175 78 LG:1387485.6:2000SEP08 2944136F6 907 1283 78 LG:1387485.6:2000SEP08 2944136H1 907 1198 78 LG:1387485.6:2000SEP08 3495979H1 912 1194 78 LG:1387485.6:2000SEP08 g1202624 939 1381 78 LG:1387485.6:2000SEP08 g1012265 955 1249 78 LG:1387485.6:2000SEP08 g1042452 956 1258 78 LG:1387485.6:2000SEP08 g983177 962 1336 78 LG:1387485.6:2000SEP08 3049691 HI 963 1254 78 LG:1387485.6:2000SEP08 gl218110 1001 1269 78 LG:1387485.6:2000SEP08 2652533H1 1016 1269 78 LG:1387485.6:2000SEP08 2098947H1 1224 1456 78 LG:1387485.6:2000SEP08 1309581 HI 1328 1575 78 LG:1387485.6:2000SEP08 1004812H1 1367 1552 78 LG:1387485.6:200OSEP08 1568541 HI 1392 1607 78 LG:1387485.6:2000SEP08 2764023H1 1 259 78 LG:1387485.6:2000SEP08 530901 HI 2 134 78 LG:1387485.6:2000SEP08 4049678H1 11 290 78 LG:1387485.6:2000SEP08 3594169H1 11 279 78 LG:1387485.6:2000SEP08 4330447H1 17 271 78 LG:1387485.6:2000SEP08 4565262H1 39 285 78 LG:1387485.6:2000SEP08 6408733H1 162 683 78 LG:1387485.6:2000SEP08 g1295497 175 615 78 LG:1387485.6:2000SEP08 7039706H1 356 875 78 LG:1387485.6:2000SEP08 986902H1 225 462 78 LG:1387485.6:2000SEP08 7939046H1 446 921 78 LG:1387485.6:2000SEP08 7270571 HI 206 743 78 LG:1387485.6:2000SEP08 1704717H1 255 425 78 LG:1387485.6:2000SEP08 4723677H1 207 436 79 LG:230151.1:2000SEP08 g1760799 1489 1929 79 LG:230151.1:2000SEP08 2834338F6 1524 2017 79 LG:230151.1:2000SEP08 2588088F6 1290 1516 79 LG:230151.1:2000SEP08 2588088H1 1290 1533 - Λ m Λ Ό - st st t r- o o o o r-v st cN o oo N O '- rN. rv r- rN. t u j .- s. j - ^ Rj .o O O O O i— CJ CJ ^ 2 _n _ ^ j t __ (θ θ θ θ r- o rv. rv. rv. c C rv. uj _o o j Lθ rv. cj s iθ 5 ^ ∞ . ° 55 5 cN CM ^ t t N CM CM r N CN r-v rv. r- oo o !__ i— m °° ^r- _ U_J O_ _- e0 N C0 r- '- - ^ ^ ^ ^ ^ ^ iO . 00 O -) iO '0 -0 N N \ CN CN CM CM CM CN CN CM CN CN CN r- CM r- CM CN CN '— CM CN CN CM CN CM ooo coo coo oo c oo oo oo oo oo co co cpo oooooo O O O O O O O O O δδo o| N o|v,ov,or N .orv.or N or-voiv. oooooooooooooooooooo 00 o Q. ιO O cO CN O O CN CN O r . ( ^ - ) ^ . ) UJ | v. c C st O θ rv. rv. O J CM cO CO cO CN CN O n c c r- c^ θ - -- c> ^ f y 3 ^ co C ι θ r- c st N θ θ θ θ o o o u uj uj u j LQ j uό j ^ O CO O OO CO CO r S ^ & S u sf ^ ^ -^ ^ ^ U UJ J U UJ U UJ J U U UJ U UJ UJ U U U UJ Uj Λ C CM CN CN CN CM CN CN CM CN CO CJ CN Sf o co r-v H U α. UJ O O O O LO |V . Γ N I ,— O rv. cO O O O CM c CN ^ r- CN n $5 N^ n'- ._o CN> Cr-. _- .[S c<θJ ^c r- ) n θ WO Oθ N CN Cr-0 ^ Nt Ct. QO 5O nt ( v^. - ) '- ^ IN - ) Q '- <. 'Q ) r - _ n C NM NCN CNN CcoN -CM ) C-M ) CN. C.M CN. S 0 S 10 < c. ^ '~ ccN. c-_. SC0 '_-- W_- N_- SC0 n_- _-. -_- ^_- ( _- '_-- n_- SO '_-- -_- -_- _-. -_- -_- ^_- ^_- -_- -_. '_-- '_f- o_- -_- o_- c__. '_-- -_- Srv. 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Q — Oo Oo OoOoOoOoOoOoOo OoOoOoOo Oo OoOo OoQoOoOoOoOoOo OoOo OoOoOoOpOpOoOoOoOooOoOoO OoOoOooO OoOoQoOoOoOoOoOoOo φ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O -^ CN C CN C C C CN CN CM CN CN CN CM CN CN CM CM CM CN CM CM D ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ iO o ύj iij io in in io in io io in i ύj P- r^ r^ r^ r^ r^ r^ r^ r^ r^ r^ r-^ r^ r- ' r— r- OO CO θd cd θd θO θO c θO c cO θd θO » t lO UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ U UJ UJ UJ UJ UJ UJ UJ UJ U^ ^ O O O O O O O O O O O O O O O UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ Uj Lθ UJ J UJ J UJ UJ UJ UJ UJ UJ UJ UJ J UJ j !_ lθ CJ CO CO CJ CJ C CJ CJ C^ CJ CJ CJ CJ CJ r— r- r- i— r- r- r— r- r- r- r- r- i— r- r— r— r- r- r— r- r— ι— r- r— r- r— i— r- r- i— i— r— r— r- r- CN CN CN CN CN CN CN CN CN CM CN CN CN CN CNI CN CN CN CN CN CM CN C^ 0000000000000000 ∞oooooωoooooffloococoooooocoocoo- cooo-)(oD(o0(oDooooco <oocoooooocoocoocooooocoo(Doooooo *o o R-o -- g S 2 i8 ^ r l S -- cN - o o uj vt st o - rv. O cO O CO O CO θ r N . rv. CM O -N -N O c OO O sf CM O O rv- O O st t O uj co uj O rv st st CN CN O 00 st rv r v . |-v r- r- o O O O CM O O O O CN CJ O OO cO f Iv. _J Cθ 2 ? r ? L!≤Π m2 c?) 2 r 5 o>o oOo oOo oOo oOo Orv. Or v . O ^o st st CD O O O O O O H U α. o CO CO 00 CO 00 00 CL o CL o CL o CL s_ o Q- oCL o CL LU LU LU LU LU LU O CO CO CoO ι CO CO od od CO CO UJ UJ UJ J UJ UJ UJ UJ UJ UJ UJ J UJ UJ J UJ UJ o z o Q o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o G o _- _J st UJ O O sf O UJ UJ O O O rv. O 00 r- i- ^ U 'J J c '— O CM CJ -— ■— ^ |v. cO UJ UJ CJ j rv. cj O O r N i . - . rr . f^ J st Uj rv. ^ n rv. cM r- r- v r N . co r- ^ rv co uj o o o oo - u uj uj j c CM Uj cN CM CN C '— sf g- o oo -o cj cj uj u uj g; W y S st u o o cj o -y cO c rt cO CN C CN CJ C st st st st i st st UJ UJ UJ UJ UJ J UJ UJ UJ UJ UJ UJ UJ UJ CO st st st cj sf sf UJ UJ U^ UJ St CM CM CN CN CM CM H U α. o I-- z o Q O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O r- r- r- r- r- r- 00 00 co oo co co oo co co co co co co co co co oo co co co co co αj cD oo co oo αo oo co co co co co co co co co co co co co ∞ o G O so o CN O CM UJ Sf O O CJ CO O — r- r- r- r- CM H U α. t O ffi i- O O- N CM r- C .M. _ «t c5J C^M CN r N . rv CO CO O UJ oO CN CN CN O O O O CO O UJ UJ t UJ st π co cj o oo co j uj uj _ st ιo " r C NO- s cM rOv 5-_ § o§ θ§ cQ ■— Γ ?. O O ΓN. O '— CM CM CN cO O O Q cO st g J st o cj r- CN CJ CJ CM CJ CJ CJ CJ sf t sf CN 00 jή CN CJ CJ CJ r- CN CM CN CM CN UJ UJ J UJ s CO CM CN CM CN CN CM CN CM -M C CN CM CM CN CM CM _. _. O O UJ s ^ r- t s} - 5 t « ^- 3 r v . O o p o o o o o o o o D 11.1 _ M_l Q in. Q in. l i_n. α. Q. α _- -. co co co co co co o o o o o o o o o o O O Q O O O O O O O O O O O O O O O O O o I-- o —. co co co oo oo co oo co co co co oo co oo oo oo co co oo co co oo oo co oo oo oo oo co co co co oo oo co oo oo co co oo oo co ∞ o G o TABLE 5 ID NO: Template ID Component ID Start Stop 81 LG:235840.1:2000SEP08 7613750H1 1669 2267 81 LG:235840.1:2000SEP08 4898449H1 1682 1867 81 LG:235840.1:2000SEP08 3464906H1 1690 2022 81 LG:235840.1:2000SEP08 004533H1 1582 1874 81 LG:235840.1:2000SEP08 6730659H1 1604 1825 81 LG:235840.1:2000SEP08 41 6254H1 2224 2519 81 LG:235840.1:2000SEP08 5914590R8 1568 2109 81 LG:235840.1:2000SEP08 2960481H2 1566 1853 81 LG:235840.1 :2000SEP08 5056390H1 1578 1850 81 LG:235840.1:2000SEP08 5034382T6 2283 2679 81 LG:235840.1:2000SEP08 2676562H1 2277 2526 81 LG:235840.1:2000SEP08 5693701 HI 2282 2543 81 LG:235840.1:2000SEP08 7738333H1 2045 2594 81 LG:235840.1:2000SEP08 4664169T6 2049 2595 81 LG:235840.1:2000SEP08 639274H1 2058 2332 81 LG:235840.1:2000SEP08 544137H1 2149 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O UJ O UJ C0 CN CN O rv, rv. st r— O UJ C o o o st oo c rv. E; st t gJ ^ rv O CN St sf st CN UJ UJ O ■— rv, O C O c cj uj CM r— c o co sj u cg cj co o UJ UJ st UJ 0O -- CJ CN — O O CN U U st UJ O CJ ^ ■ y- π • -J ^ J r- r CM st g o o SS r- UJ st O OO OO OO O UJ CO I-v UJ r- o rv. st CM O — O J O O ^ OO O ^ ΓV lO s st st st sf t . O - r- O O CM CJ 00 O O O O CO CN '— CM CM C CM r- r- r- r_ r_ r_ r_ r- r- r- ' J UJ '- UJ O U C -J O - O^ ^ ^ OO O CO OO O UJ O rv. H U α. t vt st O O st vt st CM rv. CO rv. O O CO s -| 0 _0 CN co CJ o CJ CJ CO CM CN st st st UJ UJ Sf UJ UJ CJ CJ CJ CJ UJ < CM CM CN C CN cO c CJ cO c c CJ CJ CJ CJ CJ CJ CO cO CO CJ cO CO CJ CJ CJ st st st sf st sf sf st s^ CO 00 ω co » o ω co rø ω ω «ι » ω ι» co co ω co co co ffl ffl co ffl cβ co (c o5 co co ® co cθ (θ co co co « (a ffl co cθ (» co co co co co ffl TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 85 LG:408751.3:2000SEP08 7359626H1 379 948 85 LG:408751.3:2000SEP08 4338771 HI 359 628 85 LG:408751.3:2000SEP08 g708822 393 694 85 LG:408751.3:2000SEP08 g764692 395 736 85 LG:408751.3:2000SEP08 g816062 372 784 85 LG:408751.3:2000SEP08 7587293H1 379 952 85 LG:408751.3:2000SEP08 3864471 HI 374 591 85 LG:408751.3:2000SEP08 6990907H1 383 885 85 LG:408751.3:2000SEP08 6866026H1 381 974 85 LG:408751.3:2000SEP08 5674272H1 391 645 85 LG:408751.3:2000SEP08 6120160H1 391 790 85 LG:408751.3:2000SEP08 6448066H1 412 963 85 LG:408751.3:2000SEP08 7580272H1 393 907 85 LG:408751.3:2000SEP08 g691925 443 755 85 LG:408751.3:2000SEP08 533539R6 424 939 85 LG:408751.3:2000SEP08 4705993H1 1999 2149 85 LG:408751.3:2000SEP08 7158434H1 2001 2270 85 LG:408751.3:2000SEP08 6983326H1 2077 2666 85 LG:408751.3:2000SEP08 6770575H1 2300 2823 85 LG:408751.3:2000SEP08 6765966H1 2133 2654 85 LG:408751 ,3:2000SEP08 7580816H1 2166 2665 85 LG:408751.3:2000SEP08 1270536H1 2175 2415 85 LG:408751.3:2000SEP08 7281449H1 2232 2815 85 LG:408751.3:2000SEP08 7582690H1 2242 2758 85 LG:408751.3:2000SEP08 7275431Jl 2370 2836 85 LG:408751.3:2000SEP08 5920291 HI 208 267 85 LG:408751.3:2000SEP08 1456735F6 189 605 85 LG:408751.3:2000SEP08 6721132H1 193 579 85 LG:408751.3:2000SEP08 4203426H1 212 337 85 LG:408751.3:2000SEP08 1992224H1 206 475 85 LG:408751.3:2000SEP08 7259028H1 204 579 85 LG:408751.3:2000SEP08 g766593 289 587 85 LG:408751.3:2000SEP08 7058996H1 309 890 85 LG:408751.3:2000SEP08 g570855 2997 3307 85 LG:408751.3:2000SEP08 5371992H1 3015 3187 85 LG:408751.3:2000SEP08 g389944 3100 3330 85 LG:408751.3:2000SEP08 2416693F6 3191 3330 85 LG:408751.3:2000SEP08 2416693H1 3191 3330 85 LG:408751.3:2000SEP08 g318775 3202 3330 85 LG:408751.3:2000SEP08 1594111 HI 3236 3330 85 LG:408751.3:2000SEP08 g389942 3242 3330 85 LG:408751.3:2000SEP08 5406949T6 1495 1919 85 LG:408751 ,3:2000SEP08 5945223H1 1574 1656 85 LG:408751.3:2000SEP08 6773005H1 1585 2157 85 LG:408751.3:2000SEP08 6869723H1 1599 1944 85 LG:408751.3:2000SEP08 g2985356 1730 1957 85 LG:408751.3:2000SEP08 6768978H1 1703 2265 85 LG:408751.3:2000SEP08 2154505H1 1905 2188 85 LG:408751.3:2000SEP08 7585176H1 1906 2405 85 LG:408751 ,3:2000SEP08 2154505F7 1906 2204 _- o co o t rv v r N O r- r- t c oo o o r iN cj i— o r- o ~ "~ "_ ?; t C ( O D N-. CT N-. Γ V. -8. T ^T T T ^T O O O ΓN O O O O O O O H U α. _P n- c5 rv O O Cj co oθ o o ^ S ^ c r- r- co co co oo oo cj t oo uj o oo o co o o g co co oo Q cj c co co o cj r- L θ ό rv. 0 0 0 2 _ _ O rN rN [N [N rN CO 00 O O 0 0 O O O O c0 st st st st L0 UJ CJ CJ CJ CJ c0 St L0 st st st st -f- -t s —t J s CO < o z: o — co co co co co co co oo o- co co co oo oo co co oo oo co oo co co co co co co co co co co oo co co co co co ∞ o G O TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 85 LG:408751 ,3:2000SEP08 6572506H1 1480 2041 85 LG:408751.3:2000SEP08 7410777H1 1480 2021 85 LG:408751 ,3:2000SEP08 g5511164 1289 1671 85 LG:408751.3:2000SEP08 g3649444 1290 1673 85 LG:408751.3:2000SEP08 g314750 1302 1671 85 LG:408751.3:2000SEP08 g775420 1276 1685 85 LG:408751.3:2000SEP08 g4617815 1287 1678 85 LG:408751.3:2000SEP08 g314920 1339 1671 85 LG:408751.3:2000SEP08 1270695T6 1192 1632 85 LG:408751.3:2000SEP08 4717574T6 1201 1650 85 LG:408751.3:2000SEP08 1476570F6 1203 1671 85 LG:408751.3:2000SEP08 1476571F6 1203 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LG:408751.3:2000SEP08 6888770J1 153 753 85 LG:408751.3:2000SEP08 g615989 174 503 86 LG 1078933.1 2000SEP08 2730285H1 654 890 86 LG 1078933.1 2000SEP08 g2728816 753 922 86 LG 1078933.1 2000SEP08 4002923H1 773 1072 86 LG 1078933.1 2000SEP08 g2537503 800 1089 86 LG 1078933.1 2000SEP08 gό299364 1051 1124 86 LG 1078933.1 2000SEP08 4992604T6 442 970 86 LG 1078933.1 2000SEP08 2795327H1 459 701 86 LG 1078933.1 2000SEP08 6000894T8 511 998 86 LG 1078933.1 2000SEP08 4992604F6 1 561 86 LG 1078933.1 2000SEP08 4992604H1 1 207 86 LG 1078933.1 2000SEP08 7264011 HI 45 555 86 LG 1078933.1 2000SEP08 4251691 HI 398 656 86 LG 1078933.1 2000SEP08 5305837H1 410 651 86 LG 1078933.1 2000SEP08 2651913F6 438 990 86 LG 1078933.1 2000SEP08 2651913H1 438 683 86 LG 1078933.1 2000SEP08 1720617T6 592 1054 86 LG 1078933.1 2000SEP08 4030861T6 612 1166 87 LG:958731.1:2000SEP08 6274461 H2 1 390 87 LG:958731.1:2000SEP08 6274461 F8 1 586 87 LG:958731.1:2000SEP08 6274461T8 394 1095 88 LG:024125.5:2000SEP08 7937162H1 1 577 88 LG:024125.5:2000SEP08 3359165H1 14 254 88 LG:024125.5:2000SEP08 927867H1 28 176 88 LG:024125.5:2000SEP08 4729644H1 32 297 88 LG:024125.5:2000SEP08 g5430947 34 309 88 LG:024125.5:2000SEP08 g6300785 626 783 88 LG:024125.5:2000SEP08 g3918107 627 783 88 LG:024125.5:2000SEP08 1848687T6 640 818 88 LG:024125.5:2000SEP08 g4078394 641 783 88 LG:024125.5:2000SEP08 g6301603 646 783 88 LG:024125.5:2000SEP08 g4109417 671 783 88 LG:024125.5:2000SEP08 3799006H1 673 805 88 LG:024125.5:2000SEP08 g5531063 676 783 88 LG:024125.5:2000SEP08 g2115664 677 783 88 LG:024125.5:2000SEP08 g4004611 682 783 88 LG:024125.5:2000SEP08 g3417887 690 783 88 LG:024125.5:2000SEP08 g3422421 690 783 88 LG:024125.5:2000SEP08 gl 141030 716 783 88 LG:024125.5:2000SEP08 g3078258 744 820 88 LG:024125.5:2000SEP08 g873980 752 809 88 LG:024125.5:2000SEP08 g5431328 622 805 88 LG:024125.5:2000SEP08 1528650H1 625 829 88 LG:024125.5:2000SEP08 3246738H1 568 823 88 LG:024125.5:2000SEP08 4544253H1 571 808 88 LG:024125.5:2000SEP08 4329943H1 557 759 88 LG:024125.5:2000SEP08 4270595H1 567 820 88 LG :024125.5:_ 2000SEP08 2995696H1 549 800 GO CM _ CM- O 9- UJ CJ f CJ O C O O J O sf UJ CJ C CMM OO ssft CM IN O CM CO O CJ IN CN O UJ CJ O O Cj rv rN O UJ O r— IN O IN CΛ O st oo O 00 CJ O O O UJ O CJ IN O~ O—O OO CJ O OO Sf lN OO IN O CN r- |N θ r- rN CO CJ CM r- r- O CJ O O CO St t C CJJ CN ±: IN IN IN IN IN 5 CJ t CJ CJ CM CJ CN •— CM CM CN -N CJ UJ r- cO CN CJ r- CM CJ CJ CM CM CJ st 'vt UJ OO rN CO St O St CN O st cO CJ H U α. 00 00 00 00 00 00 CO CO 00 OO 00 CO oo CO oo CL CL CL CL CL CL CL CL CL CL CL 0_ LU LU LU J LU LU LU LU LU LU LU LU U LU UJ CN CN CN CN CM CM CN CN CM CN CM CN CM CM CM CM CM CM CM uj uj cj CM C CN CM CN CM CM CN CM CM CN CN CM CM CM CM CM CM CN C Sf CO CN CN CN CM CM CN CM CM CM CM CN CN CN CM CM CM CM CM CM IN 00 CO co co oo oo oo oo oo oo co co co co co oo oo co co co oo co oo oo oo oo oo oo co oo oo oo oo co co oo oo co co co oo oo oo oo oo oo oo oo oo o CO CO CO -O CO CO OO OO CO CO CO OO OO OD OD 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'J O '- ^ ιo o ® « ^ |£ » θ ffl « ^ ^ ιιj c. ιo -j ^ o> ^ ^ ° ° ^ N) ^ ^ c N -) -) -. n ιθ Nr H U α. -_ O CM O U) UJ UJ r- r- cO π CN O r- Lθ _ CN CD CN _ t t O O st ΓN o O o UJ CM CM st st CM " ^ IN r- (N fN IN •— i— i— IN ΓN r- C . r- 1- CN CN CN CN st CO 00 00 CO 00 CO CO CO 00 CO CO 00 00 CO CL CL CL Q. CL CL CL LU CO CO O oCM o CMoCMo o o _ CM IN IN IN |N |N CO o o o ΓN CO O o o Z L . o o O o z nt_ oo oo O O O O O O O O rN rN rN rN rN rN rN r rN rN r r rN rN r iN o co co co co co co co oo co co o S ^ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o θ o o o o o o θ o ~ ^ι ~ ~ o < o L_U CO J m o o o o oo o o o o o o o o o o o o o o o o o o o ooo o o o o o oo o ooo o oo o o o o o o o o o N M M r r M rO t M tO M rO M M rO M M M M M M N D o eo co °i°_oooooooooo NO NO ON NO ONON ON ON ON -φ. Nl j Nl Nl Nl Nl --- --- --- --- --- --- Q oo oo op o o o pv-j CΛ C kS O O O O O O O O O O 00 ro ro ro ro ro ro ro N NJ ro ro ro — ■ ro ro ro ro ro ro ro — ■ t_ b ω ω oi o n 4-- 4-. co ooco co ro ro ro _, oooo oo .fc- 4-- 4-. 0 KB N -. ω σ -i -' j- — • →- — ■ — • — . O O .J 2 N o NJ NJ 00 —i —■ ro e en o oo o — ' Co oo — - co Q o cn ro ro ro o _ O o_ O o_o_ O o_ - c .- O o c — O o g. N _ NI2 J . 0 o en s c O o - j- ω ϋibω-Oi t-- 1 oo NI —- ro ro o ro NI NJ NJ 00 —' O 0_0 oNl Ni Ni en o o Ni en ro — ■ O . e Nn r eOn N enJ N I " rr -O NI -J Nt -OJ Nt-OJ r - J -, κ- M . 1 ., M I M ^ ^ ^ M M M .^ -- en c o o to-OJ W oN-J NM ς-J rrc -OO n - ^—c —» ' —- -' ' M -NJ r .NO ' ioJ_ -—-»_' • -—C-D_' ' _ - 1 , ~ a » ~ g « ^ J r ^ 5 N > c — ■ o ^ ^ S -' ^ - ^ ^ ^ ^ o o ^ j ω 0 cn -H. cn o o ω o c» α o o o o o w o o o o ^ g o g ∞ o o o o -__ . _. c> ro o g : : — o to C0 O 4-- C04-- 4-- r O Cn — ■ N 'O I W & ω fl w ω w w ro w βl W I 0 ^ l> _ n Cn ϋι O' 0 - ' i 0 cl t ' co f l (> - CN St c cO IN CN -t oO CJ st CM CM r- cj O O O CJ O -O CM O O r- OO CO sf vI vt rN CN CJ O CJ O CJ O ■— St |N π CM UJ st CM CM UJ OO O CJ st O O CN UJ UJ sI UJ UJ O r- 'vt LO r _ o o cj c c o r- co o r- co c 0^0 i O; N r rN o ■— UJ CJ UJ O ry o o r- 'ct -J- CM CM CN O O O O O O O O r- r- CN CN CN CN CN CO CJ CJ ^ •o o N N N Ma ^ -) (. t S r- r- « CO CN CN CN .— ^ -— <— CN CM CN CN CN CN CN CM CM CN CN CN CN CN CM O SO r. o o o c. c. n c. 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'^ *+' ' LU UU UJ UJ UJ 1^ UJ --/ ^J v u OO υO' Oj- O *-_- CM O O C CO - '— o \_ / ^ ~ ~ ^ ^ ^ C sC CJ C CJ CJ CJ O CJ C CJ C CJ 3CO CN CM CM CJ CJ CM C CJ CJ CJ CJ H U α. ; sf 00 CO O cJ CJ CJ CJ CJ O r- 5 00 00 CO CO 00 co co oo OQ. O_. Oli αO O_. Ol co co co co O CN CN CN CN CN CN CN CN Z7 COO COJ COJ cOO cOO COJ CJ CJ CJ COJ COJ COO COO COO CM CN CN < CM CN CM ( CN o o -- O O O O O O rv rN CO cO oO cO oO oO oO cO O O O O O O O O O O O O O O O O O O O O O O O O O Q O O O O O O O O O O O O O O O O O O O O O O O O O r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- r- ooo oooooo ^ r- o LU o TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 110 LG:236386.1:2000SEP08 2857322H1 2920 3177 110 LG:236386.1:2000SEP08 792748H1 2924 3151 110 LG:236386.1:2000SEP08 793130H1 2925 3131 110 LG:236386.1:2000SEP08 792748R1 2925 3509 110 LG:236386.1:2000SEP08 7159471H1 2934 3484 110 LG:236386.1:2000SEP08 1541872H1 2951 3157 no LG:236386.1:2000SEP08 6559394H1 1836 2450 no LG:236386.1:2000SEP08 6553230H1 1836 2188 no LG:23638ό.l:2000SEP08 3382113H1 1906 2113 no LG:236386.1:2000SEP08 2272356H1 1647 1915 no LG:236386.1:2000SEP08 2661806H1 2112 2383 no LG:236386.1:2000SEP08 2661806F6 2112 2553 no LG:236386.1:2000SEP08 g6476309 2172 2528 no LG:236386.1:2000SEP08 2627073H1 2183 2413 no LG:236386.1:2000SEP08 2627315H1 2183 2411 no LG:236386.1:2000SEP08 3901711 HI 2270 2513 no LG:236386.1:2000SEP08 5763849H1 2373 2890 no LG:236386.1:2000SEP08 7256511 HI 2420 2921 no LG:236386.1:2000SEP08 3572311 HI 2509 2721 no LG:236386.1:2000SEP08 3572311 F6 2509 3086 no LG:236386.1:2000SEP08 7336064H1 2549 2991 no LG:236386.1:2000SEP08 2272356T6 2588 3010 no LG:236386.1:2000SEP08 685902H1 2627 2848 no LG:236386.1:2000SEP08 6831490J1 496 688 no LG:236386.1:2000SEP08 6831490H1 496 688 no LG:236386.1:2000SEP08 7738646H1 755 1252 no LG:236386.1:2000SEP08 6938224H1 973 1366 no LG:236386.1:2000SEP08 7267489H1 1082 1603 no LG:236386.1:2000SEP08 g3888759 1148 1514 no LG:236386.1:2000SEP08 6454789H1 1317 1820 no LG:236386.1:2000SEP08 684735H1 1380 1626 no LG:236386.1:2000SEP08 7649660H2 1420 2039 no LG:236386.1:2000SEP08 6952285H1 1506 2072 no LG:236386.1:2000SEP08 4458494F6 1519 1967 no LG:236386.1:2000SEP08 4458494H1 1520 1755 no LG:236386.1:2000SEP08 7255931 H2 1596 1777 no LG:236386.1:2000SEP08 6909665J1 1633 2177 no LG:23638ό.l:2000SEP08 2272356R6 1647 1966 no LG:236386.1:2000SEP08 4181419H1 1 220 no LG:236386.1:2000SEP08 6779195J1 119 758 no LG:236386.1:2000SEP08 113399R6 483 847 no LG:236386.1:2000SEP08 5104505H1 3515 3738 no LG:236386.1:2000SEP08 g4081742 3517 3883 no LG:236386.1:2000SEP08 1452312T6 3521 3836 no LG:236386.1:2000SEP08 g898312 3538 3878 no LG:236386.1:2000SEP08 6499719H1 3537 3869 no LG:236386.1:2000SEP08 g4081564 3538 3883 no LG:236386.1:2000SEP08 g2335900 3571 3880 no LG:236386.1:2000SEP08 g6451467 3573 3875 no LG:236386.1:2000SEP08 g1521304 3576 3891 90 Q. c CJ UJ CO O r- O CM UJ CM O Lθ C rN θ O CM L CM rv r- O l CO O oO st oO lN CN UJ OO O CM st r- ^t O r- oo r- OO CJ CJ O O CJ CJ UJ O OO O rN iΛ oo o ocj oo rN oo co oo oo -O st ςN cj rN O st o _ st o _ O_ CM NO CM — o o c o co o o cj r— oo Q c o st uj r- o rv o rv co cj , oo oo oo oό oo co co oo co co co co oo oo oo oo oό αj io cό st cό c uj o o st rN ^ st st co st rN rN i-j o u o c^ j c c c co co co c c cj co co c c c co c co co co co co cj c c c c co co co co cj co c co co cj co co c co co rt H U α. -t rN θ O O _N UJ rø r- ^ O (N St r- r- sI _0 CM 00 St SI CN ( r- r- ιQ 00 rN 00 00 CM UJ UJ UJ O st UJ IN vt lN rN θ C0 CM rN Q π rv cθ CO CO O CN st c -O UJ UJ O O O CO O UJ O CM CN CJ st rN θ O O O O O O rN [N rN CM C C (N C st st rN IN IN ∞ -. - UJ UJ UJ -O UJ O O O O O O O O rN rN CN r- r- ^ ^ r- r- r- CN CM CM ( CM CN CN CN CM CN CJ CJ CJ O O O O O O O O O O r- O CJ CJ CJ CJ CJ CJ CJ CO CO CO CJ C CJ CO CJ CJ CJ CO CJ CJ CJ CJ CO CO CO CJ CJ CO CJ CJ CJ CO CO CJ CJ CJ CJ CO CJ CJ UJ < 00 00 00 00 00 00 CO 00 CO CO C0 CO 00 00 C0 C0 00 00 00 00 00 00 00 00 CO CO 00 00 CO 00 CO CO 00 CO 00 00 00 00 ( O ( XJ 00 00 00 <» C0 00 00 ∞ oαoαo-.o-.ooιoo-.-o-o-.o-.o-.oιo-.-o-o---o.o-.o-.o-.oιo--ooιoαooQ.oα-o-aoo-.o-.o--oαo-.o-.o--αoo-.o-.oαoιo-.o-.oo-.oαo-.p-.o-. Q—ooooooooooooooooooooooooooooooooo ooo oooooooooooooooooooooooooooooooooooooooooooo ■ feøo o o C CMoCNoCNoCNoCNo ( oCN CMpCNoCNoCNoCMo( oCNooooooooooooooooooooooooooooooooooooooooooooooooooooooo ^ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -CJ -O ό * ό - 0 0 0 0 0 0 0 0 0 0 0 0 0O 0O CO rø 0O 0O 0O OO CO 00 0O CO 00 00 O CO O0 C0 0O 00 0O 0O OO 00 (» <» 0O 0O 0O CO 0O CO 0O CO CO 00 CO CO 00 0O CO 0O -0 CO cO cO CJ CJ cO CJ CJ co c cJ CJ CJ CO cO CO CO CO cO cO O cO CJ CJ CJ cO cO CJ CJ cO cO cO CJ CJ __ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -0 0 -0 -0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CJ CJ CJ CO CJ CJ CJ CQ CJ CJ CJ CJ C CJ CJ CO CJ CJ C CJ CJ CJ CJ CJ CJ CO CJ CJ CO CJ CJ CJ CJ CJ CJ C CJ CJ CJ CO CJ CJ CJ CJ C^ CN (N < CN CN CN CN CM < ( CM CM CN ( CN CN CN CN CN C CN CN CN <>I CN CN CM CN CN CN C^ 000000000000000000 oooooooooooooooooooooooooooooooooooooooooooooooooo TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 110 LG:236386.1: 2000SEP08 2658395H1 3974 4210 no LG:236386.1: 2000SEP08 4099042H2 3777 3887 no LG:236386.1: 2000SEP08 1243554H1 3777 3883 no LG.236386.1: 2000SEP08 7645333H1 3782 4137 no LG.236386.1: 2000SEP08 7645333J1 3782 4131 no LG:236386.1: 2000SEP08 g4325490 3795 3875 no LG.236386.1: 2000SEP08 700495H1 3961 4212 no LG.236386.1: 2000SEP08 2623608H1 3349 3576 no LG.236386.1: 2000SEP08 840648R1 3394 3875 111 LG 1015157.1 :2000SEP08 6795378F8 1 638 111 LG 1015157.1 :2000SEP08 6795378H1 2 438 111 LG 1015157.1 :2000SEP08 6795378T8 175 658 112 LG 1065433.1 :2000SEP08 4023626H1 701 980 112 LG 1065433.1 :2000SEP08 4216384H1 563 832 112 LG 1065433.1 2000SEP08 3449946H1 1 233 112 LG 1065433.1 2000SEP08 5133790T9 317 911 112 LG 1065433.1 2000SEP08 4216384F6 563 1029 112 LG 1065433.1 2000SEP08 3449946R6 1 580 113 LG:236992.4:2000SEP08 2023720H1 380 603 113 LG:236992.4:2000SEP08 5711092T6 425 897 113 LG:236992.4:2000SEP08 2023720T6 621 988 113 LG:236992.4:2000SEP08 1957414H1 645 918 113 LG:236992.4:2000SEP08 3691485H1 302 574 113 LG:236992.4:2000SEP08 7582909H1 1 443 113 LG:236992.4:2000SEP08 5711092F6 1 595 113 LG:236992.4:2000SEP08 5711092H1 1 277 113 LG:236992.4:2000SEP08 3366992F7 9 280 113 LG:236992.4:2000SEP08 3366992H1 9 276 113 LG:236992.4:2000SEP08 4415026H1 10 250 113 LG:236992.4:2000SEP08 1672338H1 18 238 113 LG:236992.4:2000SEP08 2023720F6 379 746 114 LG:1071124.1 2000SEP08 6182057F7 342 928 114 LG:1071124.1 2000SEP08 g3092207 896 1332 114 LG:1071124.1 2000SEP08 2950882H1 1035 1171 114 LG:1071124.1 2000SEP08 g3739050 494 820 114 LG:1071124.1 2000SEP08 688011OH1 1 365 114 LG:1071124.1 2000SEP08 6273782F8 656 1305 114 LG:1071124.1 2000SEP08 g1880374 545 648 114 LG:1071124.1 2000SEP08 6182057H1 668 928 114 LG:1071124.1 2000SEP08 6272957T8 583 1276 114 LG:1071124.1 2000SEP08 g1639276 582 840 114 LG:1071124.1 200OSEP08 6272957H1 755 1305 114 LG:1071124.1 2000SEP08 4290705H1 229 481 114 LG:1071124.1 2000SEP08 494966H1 245 471 114 LG:1071124.1 2000SEP08 4099889H1 225 479 114 LG:1071124.1 2000SEP08 4290705F6 228 609 114 LG:1071124.1 2000SEP08 1676346F6 213 459 114 LG:1071124.1 2000SEP08 7196034H1 1 453 114 LG:1071124.1 2000SEP08 1676346H1 213 438 115 LG :206425.2: 2000SEP08 5523393H1 1 255 cO oo C,| O z o Q ι uj uj j u uj u j uj u uj uj u u - ιθ u u ιo u u j uj uj uj uj u o rN rN rN rN rN rN rN rN rN rv iN iN rN [N o G o Q. cO st ^t CN O CN O C O St cO UJ rN θ st r- r- O O O CJ st CJ CN CM CJ CN O CM '— ■— O cO CN urj CM UJ O CM O O rN Ui n rN CM CM CM L r- 'S r- CM ^ CM CJ CJ CM -M O CM CN O O CJ Cj rv r- ,— CN -— CJ ^ OO CM O O sl; .— .— St .— CM CO CJ CO O st o o 4-. st i r iN -o rv _ uj rv U IN Lθ IN IN |N uj rN rN rN O uj o rN rN i i iN rN o rv ^ ^ 'vt ^ cN '— CM -— r- vt ^ r— IN ΓN co C r- r- r- r- r- r- r- r- r- st CM UJ H U α. t π ∞0 sOt Ost OO sOt ClN rCNN rø< CON ∞CM usθt O^ O^ Ol0 ∞lΛ OOJ MO O-0 OIN OrN OC0 0O0 OO røO r r-- r r -- - r 0- O-N C-NM st rO- rCO- OCM CO0 0θ 0 S, rS v f Svj iβ N ry. rrv I-^N- r— o C CO IN [N ^ CM CN c cO CJ CJ CJ CJ c c CJ CJ CJ cO C C CO CJ CO CJ CO CO c st ^ vt st O UJ UJ UJ UJ st st st ^ g g ^ § § § IN 00 CO o __ O O t O 00000000000000000000000000000000000000000000000000 ^ ^ ^ ^ ^^ ^ ^ ^^^ ^ ^^ ^^ ^^ ^ ^^ ^^ ^ ^^ ^^ ^ ^^ ^^ ^^^ ^^ ^ ^^ ^^ ^ ^^ ^^ ^ -l ^ r-ι co rv C0 IN |N IN αJ O n . l - st N lN UJ CM r- 00 O st UJ st ι0 L0 '- CJ st < O 00 rv CN IN θ ^ ft O on S^ cSn N ^ t c^^ OjOO r - or- SO^^ CoM Oi- CrN- rUJ- Ocj ^- oC ^ U^J st O^^t ^^ O s^f - cO St rN r- rN c r - o S H U α. Q O™O n n O O« w O O n n O n O < O°'O'O (, ' ( O , 'O ,, ' ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ (O o co co oo co oo oo oo «) co eo «) (O cO ffl eo co oO (O cO (O co -) oo (β oo co » OJ m M t t t r Nj r rN ro t r t r r t rN r r N r M t j r --- --- --- - j — . --- --- --- --- --- --- --- --- --- --- --- --- --- --- --I --- --- --- --- --- --- --- - ■ --- — i O O O O O O O O O O O O O O O O O CO OO OO 9 D. o oob oboooo ooob OO OO OO OO OO C» CJ- O0 00 00 — • — ' -^ O O O O O O NJ NJ Nj r' r r^^' . r. r r r. oOoOoOoOoO m 0O 00 00 CJO C» O0 00 OO OO C» 00 t. t- -_ ^ {_ i_ t_ i_ {_ i_ {_ ^ t_ 0 j_ {_ _. Ji t_ t_ i_ i_ t_ £- Ji £_ t_ t_ i. t_ __ _- _- <_ „ . fn Cn £ 0 0 00 0 0 0 0 0 0 0 0 0 0 -- -' -' -' -' O O O O O Cn r- -' -' -' -' C ^ ^ ^ ^ y g ω C S _ .n o o rNJ ^ ω S 2 θ. .J O α> O^ -—' i M^. M^. Mcj M4_. WO N-jl K-JI Mcn p3_i θ— • —- ' - N .i bK «o ωo θen C— 0 ■ 0— l ' 0— ! ' MCn M4_. 0- C—> ' IC ) O ! ( N! 0 i 0N'i ϋS- l θ g> g ^ g *- 5 — g j _. w w S cn ™ — ■ ϊ — C j -'- 9 o K oo ϊ — — _ —_ S *- S ^ f- ^ t. i. fc i_ 4_ 4_ t_ J_ J_ b fc t_ J_ ^ ^ t ft t ^ fc fc ^ ^ ^ ^ ^ t_ f . ,. ,. ,. . n ra -J κ n , -- -' -- Λ ιrl -- 1 , - KJ NJ KJ Co CO CJ CO C eJ C CO fe Nl oo OO CJ OO KJ NJ NJ NJ KJ CJ CO KJ . _ . - i_ ϋι - ω - g t Nj g ^ g Nj j » 0 . o c , fc ^ oo en Ni o o o -) Nj o o o NJ en o -- o rN O o oo NJ oo O CO O c0 CN CJ vt 'vt t O CN CN UJ O CO C cO CcoJ rr-- ^ o co o r- co o st O r- - N O st o st rN i— rN θ co iΛ - r u r- ^ r- ιo o rN C st st ι O CO CO CM O ~ O - r- r- Nt vt O rN IN OJ O O r- IN O l-J O O O CM CN CO CO CO CN st r- LO LO OO CM rN r- O O rN rø IN OO OO OO O O — — r- r-^ r- rN IN lN CO CO rN CO O O O O O O O O O cO OO CO CO OO CO CO CO OO O O O O O O O O O O O CO f .— ■— .— CJ CJ CJ CO CO CJ CJ CJ CJ CJ CJ CO CO CO CN CN CN CN CN CO CO CJ CO CJ CJ CO CO CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ C^ 00 00 CO CO CO CO CO OO C CO CN CN C CM CM CM CN oCM o CN o O CJ CJ J CJ J CJ CO CO CO CJ CJ CJ CO 00 CO CO CO CO 00 CO CO OO CO 00 UJ uj uj uj J UJ J UJ UJ UJ CM CM CN CN CM CN CN CM CM CM CN CM CM CM CN CM CO J CO CO CO CJ J CJ CO CJ CO CJ CJ CJ C) C) J CJ J CO CO J CJ CJ CJ CN CN CN CN CN CN CM CM CN CN CN CM CN CN CM O o Q CM CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN C^ o LU O CO TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 121 LG:233258.3:2000SEP08 6840521 HI 3890 4335 121 LG:233258.3:2000SEP08 1642516T6 3913 4287 121 LG:233258.3:2000SEP08 4533427T1 3895 4291 121 LG:233258.3:2000SEP08 g283557ό 3906 4329 121 LG:233258.3:2000SEP08 g5879910 3889 4329 121 LG:233258.3:2000SEP08 7728747J1 1892 2497 121 LG:233258.3:2000SEP08 7628991 HI 1905 2431 121 LG:233258.3:2000SEP08 7717561 HI 1990 2623 121 LG:233258.3:2000SEP08 4900264F6 2105 2383 121 LG:233258.3:2000SEP08 4900264H2 2105 2391 121 LG:233258.3:2000SEP08 7410352H1 2137 2678 121 LG:233258.3:2000SEP08 5426338H1 2626 2805 121 LG:233258.3:2000SEP08 4901947H1 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_- -_ _ _- _- _. --- --- __ --- --- _- κ -- KJ NJ NJ NJ KJ — o — oo o oo _ ro KJ o o o o O O O Cn Nl Nj oO NJ O O O -vl o O O __ 4- J- oi en -- _, co iv !-. --- -_. --. --- eri -_ e Cj- co — ■ CO 4_. o co o CJ cn o KJ —• NI O CJ o N iNj ci t- eti cti K Oo — ' KJ cn o eti oo o ro — — O O NJ f C° Qt o cn —■ o NI NJ oo oo o KJ CJl — ' 00 O CJ NJ — ' O C0 4__, 0 — ' O NJ KJ CJ — ~3 fe gg_ji°_3«3$8$ O = j - — ' S r S θo Nl c^ cjι θ. cn cn ctι cn cn cn cn cji cn cn cn oι Cn cn cn cti cn cn erι cn cn cjJ Cjι Ci ctι cn cjι Cjι cn cn cjι cn ctι Cn cn cj w oo c_o j c_o cj j cj c o e ej c j c cjj ej ej o θ) c o cj cj ω cj (_o rO M —N —-O ' rO r NJ S oo oo cn co ct i en o o J O Cn o en o en en Nj Co M -- MKJ MN r- -NJ N-J N-J' N-J' K M j OrO NO.J MM NJ NMJ -NJ' KWJ O— 1 _ -. ^., —-' • r— ' rg ^g-i N^i rg cji 4_ — - o o — - J- — ' αJ -vJ Co o o cti 4_ 4_ cj cχι cι oo eji N ^ S e> e K fe s > -- O N -i O rO tO Oi -i U 4- J- -' - « 4- Q NJ O NI O O — ■ en cj oo o o i-. o c o o oo o o o — J -O CO O 0 O ^ 0 0 0 0 ™ 00 " 0 0 0 £- c o κj cn oo — ' o o oo — ' OO O NI CO CJ — ■ _J. ϊ oo ϊoo oo o o o o o o o o --i: - 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I M M M M N) M M I -ι Cl Cjl CjJ C_ι Cn CjJ Cfl Cl C_! Oi J O O O O O O O O O O O O O O O O O O O O S 5 S S & 5 K K S 5 5 — ■ —■ —• —■ —■ —■ — ' e en &i N N NJ N K N N N Cϋ £_ i_ 4_. t- t- *- £- f-. £- i» O O O O O O O O O O O O O O O O O O O O O 00 00 03 00 C0 00 00 O O O O O O O O O ^ po po o o po po oo o po po Ni Ni Ni Ni Ni Ni Ni Nj Ni Ni Ni oo ω ω ω w ω p o ω o -^ POOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOQOC poo — w w - ftpcononoωow Moo O ω woO ωooO ω coO OO ΛoOooO wo oOoOoOQQOOO ω ω oOoO OOOOO cfl CΛ ω w w cn ωooiΛoooooooooπ m m m m m m m m m m m m m τoto)To)to)τooτ3oto)oto)To)oto)τoι-oDTo)τoooτ.3o!oιτo.'ot)-ooτ τ. O0 OO O0 00 0O 00 O0 00 O0 O0 00 O0 O0 o)ooιo-oτo.τoo'oti'oc)"oD"σ 00 O0 O0 C» 00 00 0O 00 00 W o — ' — j - CJ CJ NJ — ■ — ' — ' J 00 00 00 Nl CJ CJ O ≤ O CJ t- ^. ^. ■ C- _, _, KJ — ■ _, _, 00 00 - _- _ι _, _, rt _, _. ζ 00 CJ KJ CO NJ O O O CJ O — ' o to * w * w Nl oo o o o Q N t N ej cj r NJ 4^- --- ω o c-j j-. X-. e e c-j χ_. e cji N N CJ c>J Cti N j ( χ cβ oo oo c» c j ^ w NJ OJ O CJ O — ' O CJJ — ' CJ CJ j-. CJ O NJ 00 G- NJ O 0D NJ Cn C0 O .fc- — ' Cn co — ' OO O O O W M C)l M N U l . -' J_ M <0 » O O O « ^ 0 O - , - , C0 Cn M « M N CIi M -- -' t 0) 0> t C)l M O M -' >0 O -' -' O C>' M 'n TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 165 1092948.1 2000SEP08 3808866F8 7 463 165 1092948.12000SEP08 1525513H1 9 225 165 1092948.12000SEP08 2889208F6 8 343 165 1092948.12000SEP08 2889208H1 8 282 165 1092948.12000SEP08 7264977H1 19 611 165 1092948.12000SEP08 3016535H1 23 307 165 1092948.12000SEP08 4760775F6 40 613 166 U:380378.2:2000SEP08 6052233R8 22 497 166 U:380378.2:2000SEP08 6861022H1 138 218 166 LI:380378.2:2000SEP08 6052233H1 1 502 166 U:380378.2:2000SEP08 6052233J1 1 497 166 LI:380378.2:2000SEP08 6052233F8 1 497 167 1029674.1:2000SEP08 g6716886 1321 1562 167 1029674.1:2000SEP08 6763379J1 1073 1551 167 1029674.1:2000SEP08 676807UI 1117 1552 167 1029674.1:2000SEP08 g7039790 1343 1522 167 1029674.1:2000SEP08 6803363J1 634 1235 167 1029674.1:2000SEP08 6763379H1 221 774 167 1029674.1:2000SEP08 6803363H1 222 613 167 1029674.1:2000SEP08 6768071 HI 1 561 168 2048601.3:2000SEP08 71558389V1 1 391 168 2048601.3:2000SEP08 71558424V1 1 391 169 1186208.1:2000SEP08 4294932F6 35 302 169 1186208.1:2000SEP08 1899877H1 67 291 169 1186208.1:2000SEP08 2882961 HI 40 298 169 1186208.1:2000SEP08 1315261 HI 37 159 169 1186208.1:2000SEP08 5120882H1 29 291 169 1186208.1:2000SEP08 gl959316 67 383 169 1186208.1:2000SEP08 1313874H1 c 37 159 169 1186208.1:2000SEP08 4399221 HI 48 260 169 1186208.1:2000SEP08 g2401851 35 267 169 1186208.1:2000SEP08 1257339H1 46 267 169 1186208.1:2000SEP08 7976538H1 1 562 169 1186208.1:2000SEP08 5120882F6 29 379 169 1186208.1:2000SEP08 014670H1 34 314 169 1186208.1:2000SEP08 8099166H1 37 657 169 1186208.1:2000SEP08 1315261 F6 37 540 169 1186208.1:2000SEP08 5378061 HI 159 400 169 1186208.1:2000SEP08 5378061 F6 159 617 169 1186208.1:2000SEP08 g4265183 206 667 169 1186208.1:2000SEP08 4881456H1 300 379 169 1186208.1:2000SEP08 1315261T6 1 65 170 1170753.1:2000SEP08 6200892T8 1 296 170 1170753.1:2000SEP08 5406931 HI 256 392 170 1170753.1:2000SEP08 g2264772 1 331 170 1170753.1:2000SEP08 6200319T8 1 297 170 1170753.1:2000SEP08 6200892H1 1 420 170 1170753.1:2000SEP08 6200792H1 1 413 170 1170753.1:2000SEP08 6200319F8 12 383 170 1170753.1:2000SEP08 5406931F8 264 393 210 m o Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl vj Nl NI NI Nl Nj Nl Nl Nl NI Nl Nl Nl Nl Nl Nj Nl Nl Nl Nl Nl NI Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl Nl fe fe J-- fe fe fe fe fe fe fe fe fe fe fe fe fe fe fe CJ NJ NJ NJ NJ K) — ' — ■ — . --- --- --- --- --- --- --- --- — . — ' — ■ o o Ό 0 t J ro NJ -- — ■ fe fe — — — — - co — ' NJ C __ -_ e — ' e Ni o NJ O fe c — ' fe Nj -j NJ NJ KJ KJ o en o fe Ni fe o o __ cn ^ ro w n , ) N n to rk ,„ fI1 fB ,. . Λ. n Oo ϋi J- J- Oi -i -i - ■ w NI CJ fe fe CO C-O CO OJ fe NJ fe Nl NI CJ CO fe CO NI KJ — ' CJ CJ CΛ o cji cxi N g oo o S -fe S N l N l N. N ^ . f S -' e c oo o o o c -' Nl Nl NJ OO OO Nl O O fe NJ — ' — ' — ' Nl — ' — ' NJ O O fe O O O o o iNj e ^ t S o ^ ^ ^ ^ ^ ^ g o- O ^ fe n co Nj Nj r fe fe Nj O CJI Nl o c j Nl O KJ O O CO fe fe O O fe O O O OO O O TJ TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 174 LI: 1039974.1 2000SEP08 6893004J1 689 1290 174 LI: 1039974.1 2000SEP08 7438574H1 1013 1333 174 LI: 1039974.1 2000SEP08 7709152J1 1039 1598 174 LI:1039974.1 2000SEP08 3423941 HI 1085 1344 174 LI: 1039974.1 2000SEP08 3423941F6 1085 1374 174 LI:1039974.1 2000SEP08 6982460H1 1104 1534 174 LI: 1039974.1 2000SEP08 6947579H1 1112 1620 174 LI:1039974.1 2000SEP08 7763864H1 1 489 174 LI:1039974.1 2000SEP08 70938370V1 763 961 174 LI:1039974.1 2000SEP08 3463824F6 844 1240 174 LI:1039974.1 2000SEP08 3463824H1 844 1063 174 LI:1039974.1 2000SEP08 70941631V1 856 1063 174 LI:1039974.1 2000SEP08 7091561 HI 871 1157 174 LI:1039974.1 2000SEP08 71152516V1 891 1393 174 LI:1039974.1 2000SEP08 6883174H1 906 1417 174 LI:1039974.1 2000SEP08 6883129H1 906 1237 174 LI:1039974.1 2000SEP08 6996726H1 907 1480 174 LI:1039974.1 2000SEP08 7663341Jl 924 1545 174 LI: 1039974.1 2000SEP08 70941275V1 924 1063 174 LI: 1039974.1 2000SEP08 g1695282 710 919 174 LI:1039974.1 2000SEP08 71152694V1 626 1063 174 LI:1039974.1 2000SEP08 7091561 F8 671 1149 174 LI: 1039974.1 2000SEP08 71151884V1 685 1063 174 LI: 1039974.1 2000SEP08 1251928H1 1166 1438 174 LI: 1039974.1 2000SEP08 7707065J1 947 1424 174 LI:1039974.1 2000SEP08 3463824T7 976 1081 174 LI: 1039974.1 2000SEP08 7746155J1 993 1346 174 LI:1039974.1 2000SEP08 71301718V1 647 1063 174 LI:1039974.1 2000SEP08 7639946J2 416 1070 174 LI:1039974.1 2000SEP08 7121329H1 490 909 174 LI:1039974.1 2000SEP08 7735245J1 669 1255 174 LI:1039974.1 2000SEP08 3337158H1 564 843 174 LI:1039974.1 2000SEP08 71302652V1 584 1112 174 LI:1039974.1 2000SEP08 71301474V1 595 1108 174 LI:1039974.1 2000SEP08 7709152H1 532 1137 174 LI:1039974.1 2000SEP08 7091561 R8 319 951 174 LI:1039974.1 2000SEP08 7678465H1 239 692 174 LI:1039974.1 2000SEP08 5517746H1 346 566 174 LI:1039974.1 2000SEP08 8036193H1 406 1033 175 LI:1175765.2 2000SEP08 6985759F8 1 481 175 LI:1175765.2 2000SEP08 6985759R8 1 481 176 LI:313948.1:2000SEP08 g4150106 244 602 176 LI:313948.1:2000SEP08 g2930824 278 601 176 LI:313948.1:2000SEP08 8025310J1 1 593 176 LI:313948.1:2000SEP08 8020685J1 29 593 176 U:313948.1:2000SEP08 g5111878 111 569 176 LI:313948.1:2000SEP08 g4533060 154 569 177 U:335923.2:2000SEP08 6243152H1 1 565 177 LI:335923.2:2000SEP08 528371OH1 8 159 177 Ll:335923.2:: 2000SEP08 5283642H1 8 201 212 TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 177 LI:335923.2:2000SEP08 201 1071 R6 15 484 177 LI:335923.2:2000SEP08 201 1071 H1 15 221 177 LI:335923.2:2000SEP08 5283929H1 23 296 177 LI:335923.2:2000SEP08 5283676H1 23 285 177 LI:335923.2:2000SEP08 6247161 HI 23 479 177 LI:335923.2:2000SEP08 g2035703 28 384 177 U:335923.2:2000SEP08 2005418H1 168 357 177 U:335923.2:2000SEP08 g4683784 245 728 177 U:335923.2:2000SEP08 g3678673 308 738 177 U:335923.2:2000SEP08 g4734389 311 735 177 U:335923.2:2000SEP08 g3038675 646 737 178 U:345884.1 :2000SEP08 g2240240 1 315 178 U:345884.1 :2000SEP08 4676488H1 8 263 178 U:345884.1 :2000SEP08 4676488F6 7 392 178 U:345884.1 :2000SEP08 776081 UI 59 265 178 LI:345884.1 :2000SEP08 g4991320 192 650 178 LI:345884.1 :2000SEP08 4676488T6 214 620 178 LI:345884.1 :2000SEP08 g7319648 465 557 179 LI:417127.1 :2000SEP08 5854850T8 1 541 179 LI:417127.1 :2000SEP08 5854850F8 1 556 179 Ll:417127.1 :2000SEP08 5854850H1 1 286 180 LI:451710.1 :2000SEP08 5914133H1 1 282 180 Ll:451710.1 :2000SEP08 5914133F6 1 630 180 LI:451710.1 :2000SEP08 5321108F9 1 537 180 U:451710.1 :2000SEP08 5914133F8 1 391 180 LI:451710.1 :2000SEP08 5914133T6 52 609 181 U:406882.2:2000SEP08 2074401 HI 1 240 181 LI:406882.2:2000SEP08 7277422H1 1 572 181 U:406882.2:2000SEP08 6387643H1 1 138 181 LI:406882.2:2000SEP08 5678260H1 2 262 181 U:406882.2:2000SEP08 3488977F6 19 435 181 LI:406882.2:2000SEP08 3488977H1 19 214 181 LI:406882.2:2000SEP08 355761 1 HI 21 316 181 LI:406882.2:2000SEP08 6771944J1 1 10 686 181 LI:406882.2:2000SEP08 g2179336 168 373 181 LI:406882.2:2000SEP08 322004H1 316 451 181 LI:406882.2:2000SEP08 322004R6 322 786 181 LI:406882.2:2000SEP08 gl l86140 342 702 181 LI:406882.2:2000SEP08 g2184370 491 909 181 LI:406882.2:2000SEP08 g 1426251 665 963 181 LI:406882.2:2000SEP08 g2715236 750 1226 181 LI:406882.2:2000SEP08 3099966T6 767 1 180 181 LI:406882.2:2000SEP08 3099966F6 774 1 198 181 LI:406882.2:2000SEP08 3099966H1 774 1087 181 LI:406882.2:2000SEP08 6984563H1 849 1340 181 LI:406882.2:2000SEP08 g2184149 860 1226 181 LI:406882.2:2000SEP08 g3801693 863 1227 181 LI:406882.2:2000SEP08 gl 153584 1000 1236 181 LI:406882.2:2000SEP08 6983618H1 1013 1165 181 LI:406882.2:2000SEP08 6983555H1 1013 1350 213 TABLE 5 _ ID NO: Template ID Component ID Start Stop 181 U:406882.2:2000SEP08 g2348522 1012 1226 181 U:406882.2:2000SEP08 g3841648 1047 1230 181 LI:406882.2:2000SEP08 g3842646 1049 1232 182 U:728223.1 :2000SEP08 6269813T8 1 599 182 LI:728223.1 :2000SEP08 6269813F8 1 658 182 U:728223.1 :2000SEP08 6269813H1 1 404 183 LI:289783.19:2000SEP08 550475R1 800 1 163 183 U:289783.19:2000SEP08 5512967H1 81 1 1037 183 LI:289783.19:2000SEP08 3326063H1 816 1 105 183 U:289783.19:2000SEP08 3401385H1 814 1043 183 LI:289783.19:2000SEP08 777649H1 833 1046 183 LI:289783.19:2000SEP08 495183H1 848 1089 183 LI:289783.19:2000SEP08 2787013H1 878 1 139 183 LI:289783.19:2000SEP08 5432830H1 889 1108 183 LI:289783.19:2000SEP08 550475H1 800 1026 183 LI:289783.19:2000SEP08 7267409H1 688 1 177 183 LI:289783.19:2000SEP08 g2537937 557 1041 183 U:289783.19:2000SEP08 60214935U1 324 873 183 LI:289783.19:2000SEP08 7084522H1 328 823 183 LI:289783.19:2000SEP08 8016832J1 1 455 183 LI:289783.19:2000SEP08 8016705J1 1 455 184 LI:235255.8:2000SEP08 5898645H1 511 773 184 LI:235255.8:2000SEP08 5901761 HI 51 1 796 184 LI:235255.8:2000SEP08 564321 1 HI 514 771 184 LI:235255.8:2000SEP08 3188563H1 523 863 184 U:235255.8:2000SEP08 7254655H1 554 911 184 LI:235255.8:2000SEP08 4569548H1 568 845 184 LI:235255.8:2000SEP08 2213566F6 580 856 184 U:235255.8:2000SEP08 2224227F6 580 1019 184 LI:235255.8:2000SEP08 2224227H1 580 823 184 LI:235255.8:2000SEP08 2834918H1 592 839 184 U:235255.8:2000SEP08 7613084H1 597 1 179 184 LI:235255.8:2000SEP08 5528066H1 610 871 184 LI:235255.8:2000SEP08 675898H1 634 903 184 LI:235255.8:2000SEP08 70568158V1 660 1065 184 LI:235255.8:2000SEP08 4625774H1 1 250 184 LI:235255.8:2000SEP08 4625546H1 5 259 184 LI:235255.8:2000SEP08 7203158H1 90 447 184 LI:235255.8:2000SEP08 70300587D1 120 420 184 LI:235255.8:2000SEP08 70513655D1 122 698 184 LI:235255.8:2000SEP08 6883819H1 185 453 184 LI:235255.8:2000SEP08 6777538J1 224 898 184 LI:235255.8:2000SEP08 7680150J1 272 878 184 U:235255.8:2000SEP08 3594396H1 283 584 184 U:235255.8:2000SEP08 4383752H1 285 541 184 U:235255.8:2000SEP08 70570626V1 294 969 184 LI:235255.8:2000SEP08 5501591 OH 1 310 726 184 LI:235255.8:2000SEP08 744281 HI 317 547 184 LI:235255.8:2000SEP08 761 975H1 318 826 184 LI:235255.8:2000SEP08 1436369F1 317 798 214 TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 184 U:235255.8:2000SEP08 7619975J1 360 901 184 U:235255.8:2000SEP08 5021074H1 349 613 184 U:235255.8:2000SEP08 5020874H1 349 617 184 LI:235255.8:2000SEP08 70566905V1 376 466 184 LI:235255.8:2000SEP08 7688171J1 381 901 184 LI:235255.8:2000SEP08 70570192V1 414 1008 184 U:235255.8:2000SEP08 70570560V1 417 983 184 LI:235255.8:2000SEP08 5775092H1 418 911 184 LI:235255.8:2000SEP08 4533965H1 453 706 184 U:235255.8:2000SEP08 5275166H1 454 705 184 LI:235255.8:2000SEP08 2362011 HI 456 699 184 U:235255.8:2000SEP08 2362011R6 456 796 184 LI:235255.8:2000SEP08 70568674V1 462 769 184 LI:235255.8:2000SEP08 6889089J1 462 914 184 U:235255.8:2000SEP08 70553659V1 462 768 184 LI:235255.8:2000SEP08 70570674V1 462 768 184 LI:235255.8:2000SEP08 1506551 HI 478 675 184 LI:235255.8:2000SEP08 70571785V1 496 729 184 U:235255.8:2000SEP08 5903079H1 511 796 184 LI:235255.8:2000SEP08 5897612H1 511 821 184 LI:235255.8:2000SEP08 5903174H1 511 811 184 U:235255.8:2000SEP08 3029777H1 679 970 184 U:235255.8:2000SEP08 6931063H1 708 1207 184 LI:235255.8:2000SEP08 4226879H1 726 1017 184 LI:235255.8:2000SEP08 7688171 HI 736 1290 184 U:235255.8:2000SEP08 7606153J1 749 1198 184 U:235255.8:2000SEP08 1968849H1 771 969 184 LI:235255.8:2000SEP08 630569H1 770 899 184 U:235255.8:2000SEP08 3051523H1 775 1066 184 LI:235255.8:2000SEP08 6621315H1 796 1284 184 LI:235255.8:2000SEP08 2791215H1 799 1103 184 LI:235255.8:2000SEP08 1804236H1 803 1053 184 LI:235255.8:2000SEP08 1460331 HI 805 1044 184 LI:235255.8:2000SEP08 70571366V1 813 1318 184 LI:235255.8:2000SEP08 4835570H1 825 1092 184 U:235255.8:2000SEP08 3150504H1 837 951 184 LI:235255.8:2000SEP08 7931885H1 839 1427 184 U:235255.8:2000SEP08 5041870H1 841 1081 184 LI:235255.8:2000SEP08 2433958R6 849 1394 184 U:235255.8:2000SEP08 6840250H1 866 1015 184 LI:235255.8:2000SEP08 4899142H2 863 1149 184 LI:235255.8:2000SEP08 4898538H1 863 1138 184 U:235255.8:2000SEP08 7071147H1 876 1275 184 LI:235255.8:2000SEP08 3663348H1 877 1153 184 LI:235255.8:2000SEP08 5605778H1 878 992 184 LI:235255.8:2000SEP08 7215091 HI 878 1135 184 U:235255.8:2000SEP08 893148H1 906 1188 184 LI:235255.8:2000SEP08 1652130H1 906 1145 184 LI:235255.8:2000SEP08 2691823H1 923 1162 184 LI:235255.8:2000SEP08 600445H1 927 1159 215 TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 184 U:235255.8:2000SEP08 7658901Jl 954 1477 184 LI:235255.8:2000SEP08 3725892H1 974 1263 184 U:235255.8:2000SEP08 2272178H1 976 1247 184 U:235255.8:2000SEP08 3725965H1 975 1256 184 LI:235255.8:2000SEP08 6910727J1 986 1098 184 LI:235255.8:2000SEP08 4859915H1 1000 1239 184 LI:235255.8:2000SEP08 6883819J1 1014 1509 184 LI:235255.8:2000SEP08 1361213H1 1018 1250 184 LI:235255.8:2000SEP08 1361092F1 1018 1350 184 LI:235255.8:2000SEP08 1718984T6 1029 1514 184 LI:235255.8:2000SEP08 1705634T6 1033 1514 184 LI:235255.8:2000SEP08 2047749H1 1037 1208 184 U:235255.8:2000SEP08 2128803H1 1041 1211 184 LI:235255.8:2000SEP08 5290142H1 1041 1286 184 LI:235255.8:2000SEP08 1641905H1 1053 1268 184 U:235255.8:2000SEP08 3089073H1 1061 1341 184 U:235255.8:2000SEP08 2418969H1 1085 1319 184 LI:235255.8:2000SEP08 6163740H1 1094 1474 184 U:235255.8:2000SEP08 g2900015 1097 1559 184 U:235255.8:2000SEP08 5108013H1 1104 1308 184 LI:235255.8:2000SEP08 2433958T6 1107 1547 184 LI:235255.8:2000SEP08 2100492H1 1112 1301 184 LI:235255.8:2000SEP08 g4896364 1132 1477 184 LI:235255.8:2000SEP08 g6044400 1149 1477 184 U:235255.8:2000SEP08 1655388T6 1149 1509 184 LI:235255.8:2000SEP08 1439226H1 1161 1420 184 U:235255.8:2000SEP08 223 189H1 1162 1408 184 LI:235255.8:2000SEP08 g3229346 1173 1561 184 LI:235255.8:2000SEP08 2071873T6 1203 1517 184 LI:235255.8:2000SEP08 2070989H1 1205 1459 184 LI:235255.8:2000SEP08 2096546H1 1222 1460 184 U:235255.8:2000SEP08 g2873693 1236 1551 184 LI:235255.8:2000SEP08 5311408H1 1275 1477 184 LI:235255.8:2000SEP08 1694442H1 1346 1560 184 U:235255.8:2000SEP08 3349083H1 1382 1556 185 LI:237693.5:2000SEP08 5083439F8 1 528 185 LI:237693.5:2000SEP08 2989661 HI 1 301 185 U:237693.5:2000SEP08 2752263R6 2 478 185 LI:237693.5:2000SEP08 5446248H1 1 264 185 LI:237693.5:2000SEP08 2752263H1 2 269 185 LI:237693.5:2000SEP08 2922381 HI 24 287 185 LI:237693.5:2000SEP08 2473969H1 33 243 185 LI:237693.5:2000SEP08 2473969F6 33 243 185 LI:237693.5:2000SEP08 3316534H1 54 296 185 LI:237693.5:2000SEP08 g4703345 65 509 185 LI:237693.5:2000SEP08 3502790H1 312 587 186 U:433670.3:2000SEP08 3319844H1 1 268 186 LI:433670.3:2000SEP08 3319844F6 1 302 186 U:433670.3:2000SEP08 7232871 HI 179 787 186 LI:433670.3:2000SEP08 4172439T6 662 1103 216 TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 187 202943.4:2000SEP08 60210577U1 1 432 187 202943.4:2000SEP08 70443926D1 31 494 187 202943.4:2000SEP08 70444091 DI 31 398 187 202943.4:2000SEP08 70443917D1 31 419 187 202943.4:2000SEP08 70442607D1 79 470 187 202943.4:2000SEP08 70444223D1 246 854 187 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202943.4:2000SEP08 2579002H2 2080 2282 188 068682.1:2000SEP08 g3307490 141 343 188 068682.1:2000SEP08 6829315H1 313 883 188 068682.1:2000SEP08 g3109791 491 810 188 068682.1:2000SEP08 g5452473 491 649 188 068682.1:2000SEP08 g4372490 78 422 188 068682.1:2000SEP08 g3805312 34 422 188 068682.1:2000SEP08 g6043518 78 422 188 068682.1:2000SEP08 g4564783 26 422 188 068682.1:2000SEP08 g5438746 1 422 188 068682.1:2000SEP08 g2954208 76 422 188 068682.1:2000SEP08 g2954218 141 421 188 068682.1:2000SEP08 g6838215 123 382 188 068682.1:2000SEP08 2011384H1 189 262 189 203301.3:2000SEP08 2613134T6 2172 2550 189 203301.3:2000SEP08 3904374H1 2189 2332 189 203301.3:2000SEP08 g5810033 2192 2612 189 203301.3:2000SEP08 7931883H1 2214 2633 189 203301.3:2000SEP08 g5540842 2229 2602 189 203301.3:2000SEP08 g7040110 2231 2602 189 203301 ,3:2000SEP08 g6658405 2231 2608 217 TABLE 5 SEQ ID NO. Template ID Component ID Start Stop 189 U'203301.3 2000SEP08 7667756H1 1 611 189 Ll'203301 3 2000SEP08 7263722H1 55 606 189 LI.203301.3 2000SEP08 2516560F6 58 548 189 Ll:203301 3 2000SEP08 2516560H1 58 402 189 LI:203301.3 2000SEP08 5541375H1 57 257 189 Ll'203301 3 2000SEP08 60212962U1 61 615 189 LI 203301.3 2000SEP08 7283792H1 69 696 189 LI 203301.3 2000SEP08 60212961 UI 69 545 189 Ll'203301.3 2000SEP08 267136H1 69 494 189 LI 203301 32000SEP08 5182929H1 74 301 189 Ll'203301.3 2000SEP08 7159563H1 86 568 189 U:203301.3 2000SEP08 1234347F1 123 720 189 Ll'203301 3 2000SEP08 1234347F6 123 628 189 LI.203301.3 2000SEP08 1234347H1 123 389 189 LI:203301.3 2000SEP08 g2079759 135 549 189 U:203301.3 2000SEP08 g318174 146 498 189 LI 203301 3 2000SEP08 60212963U1 234 677 189 U:203301.3 2000SEP08 g1509838 280 523 189 U:203301.3 2000SEP08 2074934H1 299 560 189 LI.203301 3 2000SEP08 2074934F6 299 551 189 Ll'203301.3 2000SEP08 2791160F6 320 806 189 Ll'203301.3 2000SEP08 2791160H2 320 641 189 LI:203301.3 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S -o CM 00 CM ■— O -J C UJ O vt CO O O IN CO r— 0 __ ,r- Γ CJ O0 'CVMT 0O0 'CNNJ CrvO vTJ rN O ^ , , O O C i— o o rv oo oo ΓN -j rv u o CN o lO OO CJ C CJ CJ CJ CJ CJ CJ CO ^ cM CNM O L - ■ ^Ot. Ω ^-- 5 l =_S-_ * , *- , C-NNi Oιr. ^ O O OO CO IN o o LO CO LO J vT — T — -J --- !- -- - --- --- --- --- --- - ^ CN CM vr vt -. -j Nf lO MD O' S S°2S-gg H U α. ^ OO CN O CN CN L O L Cn - CN CM C c rN -O oO O vj CM O CO CN CN . _ _ - LO O -) C * t . 2 - ■" m uj -- M - ) ■ - t o c. - ,^ cr, ~ r^ -^ r- rN rN J N N ∞ CMO iO O C. C. C. O O J5 t CJ CJ CM θ O LO oo rN o rN iN O co -' CM CM CJ CJ vt UJ lO J UJ UJ CO 00 CO CO (» C0 00 CO 00 _0 00 00 ∞ o-.-o.o-.o-.o-.o-.σ-.oαp-.o-.o-.oα-o.-o.p-.o-.o-.o-.-o.o-.o-.Do. co co co co co co co co co co O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O o o o o o o o o o p o o o o o o p o o o o o '-. '-. '-. '-. '-. • -. '-. • -. *-. '-. • -. • -. '-. • -. '-. • -. • -. -. -. '-: ■ -. '-. o--o--o--o--o--or-o- ooooooooooooooo C - lO LO UJ UJ UJ U LO UJ UJ UJ Uj L U L L oDo-oo)!o0o-oo)aco)-co)IcDoN--N --N--K--N--N--N--K--N--N--N--N --N_N_N_- O O O O O O O CN CN CN CN CN CN CN CN CM CN CM CN CM CM CN -- -- r- -- r- r - r- 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 o o - CM CN C C CM C C C C C CN CM CN CN CN CN CN C C C CN CN CN C LJ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O o UJ o TABLE 5 I ID NO Template ID Component ID Start Stop 193 LI 02175912000SEP08 7098314H1 579 949 193 LI 02175912000SEP08 2966371F6 685 1166 193 LI 02175912000SEP08 2966371 HI 686 989 193 LI 02175912000SEP08 7739693H1 745 1294 193 LI 02175912000SEP08 g1642049 756 1057 193 LI 02175912000SEP08 g1753778 957 1246 194 LI 116596712000SEP08 g6639152 1 415 194 LI 116596712000SEP08 6795757H1 1 531 194 LI 116596712000SEP08 6795757F8 1 523 194 LI 116596712000SEP08 6795757T8 1 425 194 LI 116596712000SEP08 6790411T8 140 415 194 LI 116596712000SEP08 6790411F8 141 406 194 LI 116596712000SEP08 6790411 HI 280 526 194 LI 116596712000SEP08 6795161T8 301 421 194 LI 116596712000SEP08 6795161 F8 301 522 194 LI 116596712000SEP08 6795161 HI 301 512 195 LI 116631512000SEP08 2996394H1 1 264 195 U 116631512000SEP08 2919416H2 28 275 195 LI 116631512000SEP08 2972940H1 241 530 195 LI 116631512000SEP08 2972940F6 241 389 195 LI 116631512000SEP08 2829325H1 487 756 195 LI 116631512000SEP08 2950735H1 526 796 195 LI 116631512000SEP08 71601665V1 619 1055 195 LI 116631512000SEP08 2972940T6 717 895 196 LI 20462612000SEP08 70901761VI 593 1048 196 LI 20462612000SEP08 1543453T6 610 1221 196 LI 20462612000SEP08 1921258H1 832 1046 196 LI 20462612000SEP08 1921258F6 833 1233 196 LI 20462612000SEP08 70902979V1 25 623 196 LI 20462612000SEP08 70902424V1 520 1141 196 LI 20462612000SEP08 4778273T9 559 1136 196 LI 20462612000SEP08 71269109V1 24 482 196 LI 20462612000SEP08 1543453R6 24 440 196 LI 20462612000SEP08 71268878V1 24 332 196 LI 20462612000SEP08 5055563F9 38 607 196 LI 20462612000SEP08 5055563H1 38 307 196 LI 20462612000SEP08 71269305V1 48 656 196 LI 20462612000SEP08 70899115V1 100 741 196 LI 20462612000SEP08 4778273F8 126 752 196 LI 20462612000SEP08 4778273H1 126 397 196 LI 20462612000SEP08 2724784H1 137 372 196 LI 20462612000SEP08 71269307V1 152 747 196 LI 20462612000SEP08 70901209V1 181 645 196 LI 20462612000SEP08 71269923V1 198 768 196 LI 20462612000SEP08 71270183V1 244 806 196 LI 20462612000SEP08 70900135V1 264 662 196 LI 20462612000SEP08 71270585V1 282 757 196 LI 20462612000SEP08 71268793V1 282 772 196 LI 20462612000SEP08 70899191VI 310 668 196 LI 20462612000SEP08 2925738H1 339 605 222 TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 196 U.204626.1 2000SEP08 70901814V1 399 1015 196 Ll:204626.1 2000SEP08 71270451V1 484 1071 196 U.204626.1 2000SEP08 7931380H1 497 907 196 LI.204626.1 2000SEP08 6868907H1 1 542 196 Ll:204626.1 2000SEP08 1543453H1 24 217 196 Ll:204626.1 2000SEP08 71269839V1 24 555 196 U.204626.1 2000SEP08 70902750V1 24 509 196 Ll:204626.1 2000SEP08 71269008V1 24 569 197 U.801140.1 2000SEP08 6103338H1 66 375 197 U.801140.1 2000SEP08 1415866T6 391 627 197 U.801140.1 2000SEP08 1445465H1 53 320 197 LI:801140.1 2000SEP08 6103338F7 66 594 197 LI:801140.1 2000SEP08 g1442104 1 290 197 LI:801140.1 2000SEP08 g1439745 13 306 197 U:801140.1 2000SEP08 1445465T6 44 628 197 U.801140.1 2000SEP08 1445465F6 53 367 198 Ll:286639.1 2000SEP08 g6569543 1 466 198 Ll:286639.1 2000SEP08 4138803H1 17 304 198 Ll:286639.1 2000SEP08 3595464H1 344 623 198 Ll:286639.1 2000SEP08 7687060J1 370 953 198 U.286639.1 2000SEP08 8031936J1 648 1260 198 Ll:286639.1 2000SEP08 5508394F6 681 1105 198 Ll:286639.1 2000SEP08 5508394H1 681 879 198 Ll:286639.1 2000SEP08 g2025699 726 1057 198 Ll:286639.1 2000SEP08 3217093H1 740 1010 198 Ll:286639.1 2000SEP08 3217093F6 740 1172 198 Ll:286639.1 2000SEP08 7687060H1 1022 1613 198 Ll:286639.1 2000SEP08 4919304F6 1113 1524 198 Ll:286639.1 2000SEP08 5507629H1 1179 1448 198 Ll:286639.1 2000SEP08 5832442H1 1196 1449 198 U.286639.1 2000SEP08 70449421V1 1211 1798 198 Ll:286639.1 2000SEP08 301366R6 1211 1673 198 Ll:286639.1 2000SEP08 301366H1 1211 1427 198 Ll:286639.1 2000SEP08 301366T6 1243 1769 198 Ll:286639.1 2000SEP08 3217093T6 1310 1845 198 Ll:286639.1 2000SEP08 6178302H1 1388 1561 198 Ll:286639.1 2000SEP08 491 304H1 1393 1524 198 Ll:286639.1 2000SEP08 70450250V1 1444 1656 198 Ll:286639.1 2000SEP08 g2057022 1461 1801 198 Ll:286639.1 2000SEP08 g3933409 1496 1976 198 Ll:286639.1 2000SEPO8 g3446647 1520 1976 198 Ll:286639.1 2000SEP08 g7037249 1645 2077 198 Ll:286639.1 2000SEP08 5508394R6 1791 2258 198 Ll:286639.1 2000SEP08 g5812196 1868 1967 198 Ll:286639.1 2000SEP08 g5397776 1882 2282 198 Ll:286639.1 2000SEP08 g4739487 1905 2282 198 Ll:286639.1 2000SEP08 g4739468 1907 2282 198 Ll:286639.1 2000SEP08 4249162F6 1966 2348 198 Ll:286639.1 2000SEP08 4249162H1 1966 2116 198 Ll:286639.1 2000SEP08 g3109536 2092 2282 223 - 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CM CM t t O ~ o o o H U α. -t iN CM LO O t O oo 'vt o -- c o o cj o c - cj o oo LO o rv rv cj co co t o o oo oo uj oo t n -, O 1 /N UJ C0 00 O O ( - K r . - σ 0 0 3 § 00 'vT « , vt CN L rN OO -- -- ( -0 - CJ O O C CJ - O O ^ rN r- r- CN UJ UJ UJ ' r c _ t iN vt t uj c - -t cj c cj c c -t -j - uj rN rN UJ U uj uj uj uj o o u o rN rv rN rN rN oo o co ° v . 2 ^ ^ ^ 2 ^ 2 C oo oo <» co oo co oo oo oo oo co co oo oo oo oo σo co co <» oo oo oo oo oo co oo oo oo co oo oo co oo oo co co oo co co oo «J oo oo oo co oo co rø o _L o_L o_L o_L o_L oCL o_L o_L o_L o_L o_L o_L o_L oCL o__. o_L o_L o_L o_L o_L o_L o_L o_L o_L o_L o_L o_L o_L o_L o_L o_L o p_L o p o o p o o o o p o o o p o o o rv co co co cn co co c co co co co co co co co co co co co co co co co co co co co co co co co co co co c co co co co co co ---OooOOoOoOoOooOOooOoQOoOoOoOoOoOooOOoOoOoOoOoOoOoOooOOoQoOooOOoOoOoOoOoOoOoOoQoOgOoOoOoOoOoOoOoOoOoOo iϋoooooooooooooooooooooooooooooooooooooooooooooooooo Q . ^; ;__ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^• ^ ^ ^ ^ ^_; '~: ' — C O O O O O O O O O O OO O O O O O O O O O O O O O O O O O O O O OO O O O O O OO O O O O O OO O O ^ J CN NCO CJ NCJ NCJ NCJ CCJ NCJ NCJ NCO NCJ NCJ NCJ NCJ NCJ CCMJ NCJ NCJ SCJ SCJ NCJ CCJ SCJ NCO CO CO CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ C^ CJ CJ CJ CJ CJ CJ CJ CO CJ C CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CO CJ CO CJ CJ CJ CJ CO CJ CJ CJ CO CJ CJ CO CJ CJ CO CJ CJ O 90 r- o o n to o LO IN 00 J CM - r— rN v rN v ιΛ O C0 -- O C0 ι— CN LO LO UJ UJ CN -t O LO CM CN OO LO rN .- O UJ CN OO r- n i - CM o U) U) o IN C CJ O — O -- '— O UJ UJ UJ C0 t C0 O UJ UJ CJ UJ UJ UJ r- O O UJ UJ -t CM rv "^ CJ C0 'vt -- CJ O UJ CJ UJ J i-_ I !N_ o °ι o ∞o o co o o Co) cJ Uu) -oo "-vtt t θo tt vvtt cj Luj cooo tt oo oo oo rrNv θo rrv oo oo oo oo oo oo oo oo oo Q Q θ O θO θO θO ϊ!_ , θ O UJ rINN rINN θO uUJ COj -r-— o O CJ CN CM CN CM CN CM CM CM CN CN CM CN CO CJ CJ CN CN CM CM CJ CJ CM CJ CJ CJ CJ CJ H 88 o CJ J CJ CJ — — — CM CN CN CN CM CJ U α. -t ΓN OO O B O - t — L vt -J -vT CO O O O CN O c .jj uuj vsti . j IrNN oαoj uj CN vt t o oo rN o j rN t t CJ IN CJ O — O UJ π n o IINN tt of rxii o ryvi iN |N O O O - UJ UJ UJ UJ OO CCNN t vvtt OO CCJJ CCJJ U ■" J ■" J O - C -O C —O --J o - |N O O CM -t 00 CJ t -t 00 CJ OO CO O — OO O CO IN ^ CJ rv CM C u - ) L . 0 _ 0 _ _- _- _. _- _- s 1 _ r _ CNj CM CN O _ _ O_ _ O_ _ O_ O_ _ IN IN CJ CJ CO vt UJ O O O UJ CM CN C CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN — — — CM C. CM CM CN CM OoO OoO OoO TOoCoO TOoTOp O O O O O O O O O O O O O O O O O O O O O O O O O CJ rt o r- . o Q OoOoOoOoOoOoO O O NoCNooO O O CN CNoO CNoCNoO CNoCNoO O C CoN CoO O O O O O O O O NoCNoO C oCNoO O O CNoCNoCNoCNoCNooO CN CNoCNoCNoO CNoCNoO O O O CNoCNoO C^oooOoOoOoOoOoOoOoOoOoOoOoOoOoOo o a CN CN CN CN CN C o TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 200 LI:332161.1 2000SEP08 gl 162883 2013 2342 200 U.332161.1 2000SEP08 5719879H1 2039 2437 200 U.332161.1 2000SEP08 1597684F6 2050 2516 200 U.332161.1 2000SEP08 1597684H1 2050 2258 200 Ll:332161.1 2000SEP08 5290786H1 2052 2311 200 Ll:332161.1 2000SEP08 3243490H1 2006 2243 200 Ll:332161.1 2000SEP08 g705533 2089 2251 200 Ll:332161.1 2000SEP08 2244532H1 2089 2207 200 Ll:332161.1 2000SEP08 6148317H1 2253 2752 200 1-1:332161.1 2000SEP08 7238430H1 2322 2657 200 U.332161.1 2000SEP08 6865396H1 2320 2873 200 U.332161.1 2000SEP08 6865595H1 2320 2847 200 U.332161.1 2000SEP08 g2159107 2328 2715 200 U.332161.1 2000SEP08 2263256H1 2328 2567 200 LI:332161.1 2000SEP08 6058081 HI 2241 2307 200 LI.332161.1 2000SEP08 1597684T6 2483 3012 200 Ll:3321όl.l 2000SEP08 4694344H1 2484 2590 200 Ll:332161.1 2000SEP08 4030167T8 2497 2963 201 LI:184867.1 2000SEP08 2728616H1 39 290 201 LI:184867.1 2000SEP08 70868482V1 288 920 201 LI:184867.1 2000SEP08 4897718F6 342 738 201 LI:184867.1 2000SEP08 70868801VI 1342 1956 201 LI:184867.1 2000SEP08 71229928V1 1560 2254 201 LI:184867.1 2000SEP08 70867474V1 920 1530 201 LI:184867.1 2000SEP08 71230292V1 898 1427 201 LI:184867.1 2000SEP08 71220802V1 1570 1837 201 LI:184867.1 2000SEP08 70867220V1 1199 1738 201 LI:184867.1 2000SEP08 2614428H1 1272 1523 201 LI:184867.1 2000SEP08 70870340V1 1285 1456 201 LI:184867.1 2000SEP08 g3229291 1837 2254 201 LI:184867.1 2000SEP08 g4187447 1875 2257 201 LI:184867.1 2000SEP08 g3245634 1882 2251 201 LI:184867.1 2000SEP08 g3148017 1907 2248 201 LI:184867.1 2000SEP08 g661909 1925 2261 201 LI:184867.1 2000SEP08 g3238463 2003 2252 201 LI:184867.1 2000SEP08 4897718T6 1725 2206 201 LI:184867.1 2000SEP08 g5630597 1816 2261 201 LI:184867.1 2000SEP08 70838826V1 342 614 201 LI:184867.1 2000SEP08 4897718H1 342 594 201 LI:184867.1 2000SEP08 70868224V1 342 523 201 LI:184867.1 2000SEP08 70870473V1 1292 1908 201 LI:184867.1 2000SEP08 70870290V1 343 929 201 LI:184867.1 2000SEP08 71229226V1 386 922 201 LI:184867.1 2000SEP08 5876947H1 417 693 201 LI:184867.1 2000SEP08 70870733V1 555 1027 201 LI:184867.1 2000SEP08 70868874V1 622 814 201 LI:184867.1 2000SEP08 70840206V1 662 1019 201 LI:184867.1 2000SEP08 70869882V1 725 1390 201 LI:184867.1 2000SEP08 70818463V1 785 967 201 LI:184867.1 2000SEP08 70869040V1 783 1385 227 00 CM r- CM o n K r- N K lO W « « - r- IO N r . ιn θ - - - Λ r k W & , g 3 3 N CK I0 3 ^ Λ r \ | 0' Cr f v lO -ι t rN CM CN IN UJ OO CO vt O t CΛ o θ S n n o- 3 v N S -) - ^ ^ S ) - - <) o « δ <) C) ^ N* ^ cM -) ιθ N ? ^ S - o S oo g O UJ O O UJ O O O OO UJ O ^ o g ^ ιo <2 ^ ^ α g n ^ - g |- ^ ^ 2 ° S ^ P: ^ N s N σ ^ 5 g - c g ( ^ CO C CJ CJ CJ r— CJ CJ CJ O vt H U α. t o ^ ! ∞ o cj ≤ °° r- -_ S; N t N ? ^ ( . ^ rt rSN U&J USJ Oι C_ j M lCnM Cln OS. w « - θ' 'θ ! * lv | ' O ' CN ( !θ c . 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C0 O CJ t CN _ O CM O CΛ O O ^ ^ -O O IN CM OO O C C O tG rr. O UJ CJ CM O π UJ O UJ CJ -- 5[ rsi f -N oo — o — o u co t S rv- oo co rv cM CM CJ IN • vt O IN t O t t UJ IN o 5 S CO ,n ι0 CM C. - - - C. CM M ( . (. t C CM — ■ N? -c-o-. i r N_ r _ O--- C -| C__M — f _ —- S O_. '_Λ- O C Cc O__ C ^O uC?r- oo ΓN c CM — CM H s U α. t CN Uj cO r-. rN oo — •— o oo .-, — CM — j v OO vt rN g αρ ^-. o D N oo B N m o ιn fN J v m '. c n r ι n ιn !, ' 1 Q " π O O C fN j ^ IΛ ι_- l f r g _J c CM CN CO CN & O C ϊ ^ tO < __ - C^ i- vt -t co — — S S O I N O - ^ ( . O O O Nf ^ ^ Nt ^ Nf '. l N' - S ^ m S oo -o ^ ^ O -o S S cM - — y r- ( - α J r- r- r- r- C < . CN C -- -- r- M (θ M r - ( C. r- r- r^ C . -_ -_ -- __ U3 C 0 ° O 00 C0 I _ 1 _ O U O -O < r- CM oOoOoOoOoO co oo co co rø o r- z o Q CJ CJ CJ CJ CJ CJ CO CJ CJ CJ CO CJ CO CJ C CJ CJ CO CJ CJ CJ CJ C CJ CJ CO CJ CO CJ CJ CO CJ CJ CJ CJ CJ CJ CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN C^ o G UJ o CO CN O - — vt t Uj 00 O vt 0-0_ C .J - C *q J ' 'C ;) J ' 3CJt SCJ CM : f C r M O -CJ — CO O O O O IN CM O CN O vt LO rN CO CO CO O O vr eθ - — — CN CN CN CJ O O O — CoLo_Lo_L _oL _oLo_Lo_L _oLo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_Lo_LoQ-oCLo-LpO-o-Lp---p-Lpppppppopoppppp Q o O O O O O O O O O O O Q O Q O Q O O O O O O O O O O O O Q O d O Q O Q O O O Q O O O O O O O O O O — O O O O O O O O O O O O O O O O O Q O O Q O Q O O O O O O O O O Q O Q O O O Q Q O O O O O O O O O O Φ O O O O O O O O O O O O O O O O O O O O O O P O O O O O O O O O O O O O O O O O O O O O O O O O O O π CN CN CN C CN CN C CM CN CM CN CM CM CM CM C^ ~ \- \- - ~ ~ ~ :\i ~ ~ ~ ~ ι ~ ~ ι ~ ι ~ ~ 2 ~ ι ~ : ~ ι ~ 00 O0 CO CO 00 00 CO C0 C0 CO CO CO CO CO 00 00 C0 C0 CO CO C0 00 00 00 CO CO CO CO CO C0 CO C0 C0 C0 ( U CO 00 00 C rø ^ UJ UJ UJ UJ UJ UJ UJ UJ UJ l - - UJ UJ UJ UJ UJ UJ UJ UJ UJ UJ - L UJ - LO UJ UJ UJ IO IO L L L UJ UJ UJ UJ UJ UJ UJ UJ UJ L^ -O 00 CO Cθ CO CO CO 00 00 0_ C» 00 00 -0 __ C0 CO ∞ C0 CO CD lX> C0 C0 CO CO C0 CO CO CO CO 0O C» CO CO ∞ o r- o cO cO eO rt cO cO cO cO cO O O cO cO rt cO CO CO CO CO CO cO cO cO O O O O cO cO cO O cO cO cO cO n CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN C^ o G O TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 213 LI:1185841.1 :2000SEP08 71358284V1 2678 3220 213 U:11 --5841.1 2000SEP08 2241089F6 2743 3171 213 LI:1185841.1 2000SEP08 3275630H1 2611 2893 213 Ll:1185841.1 2000SEP08 290499H1 2632 2978 213 LI:1185841.1 2000SEP08 2241089H1 2743 2990 213 LI:1185841.1 2000SEP08 2399690H1 2771 3008 213 LI:1185841.1 2000SEP08 71356842V1 2140 2807 213 LI:1185841.1 2000SEP08 71355693V1 2191 2945 213 LI:1185841.1 2000SEP08 7961057H1 2184 2857 213 LI:1185841.1 2000SEP08 71356810V1 458 1117 213 LI:1185841.1 2000SEP08 71358113V1 469 1065 213 LI: 1185841.1 2000SEPO8 8041383J1 501 1058 213 LI: 1185841.1 2000SEP08 1749048H1 515 783 213 LI: 1185841.1 2000SEP08 1749048F6 515 875 213 LI: 1185841.1 2000SEP08 70861180V1 515 727 213 LI:1185841.1 2000SEP08 70794384V1 525 1062 213 LI:1185841.1 2000SEP08 4957262F6 1524 1984 213 LI:1185841.1 2000SEP08 4957262H1 1524 1809 213 LI:1185841.1 2000SEP08 2443857F6 1524 1871 213 LI:1185841.1 2000SEP08 2443857H1 1524 1772 213 LI:1185841.1 2000SEP08 71336855V1 1564 1876 213 LI:1185841.1 2000SEP08 70797142V1 1570 2252 213 LI:1185841.1 2000SEP08 70794533V1 938 1489 213 LI:1185841.1 2000SEP08 71357423V1 970 1608 213 LI:1185841.1 2000SEP08 71351527V1 989 1192 213 LI:1185841.1 2000SEP08 71351586V1 989 1192 213 LI:1185841.1 2000SEP08 71347649V1 1032 1279 213 LI: 1185841.1 2000SEP08 3518889H1 1044 1368 214 Ll:1181710.1 2000SEP08 1476485H1 1 85 214 Ll:1181710.1 2000SEP08 1476477H1 1 205 214 U:1181710.1 2000SEP08 1476477H6 1 207 214 Ll:1181710.1 2000SEP08 1476477F6 1 546 214 U:1181710.1 2000SEP08 4398045H1 1 226 214 U:l 181710.1 2000SEP08 105065H1 327 504 214 U:l 181710.1 2000SEP08 1476477T6 122 543 214 Ll:l 181710.1 2000SEP08 105065 1 327 461 215 Ll:2048959.1 2000SEP08 g1809909 64 414 215 Ll:2048959.1 2000SEP08 3325402T7 1 458 215 Ll:2048959.1 2000SEP08 g1757886 64 317 216 1-1:798494.1: 2O00SEPO8 2110417H1 559 823 216 1-1:798494.1: 2000SEPO8 1398471HI 270 388 216 1-1:798494.1: 2000SEP08 g5880265 1 409 216 Ll:798494.1: 2000SEP08 1398471F6 151 560 216 Ll:798494.1: 2000SEP08 3382640F8 498 966 216 Ll:798494.1: 2000SEPO8 1399832H1 270 377 216 U798494.1: 2O00SEPO8 g4690049 1 330 217 LI:2049223.1:2000SEP08 4 14013T8 166 672 217 U:2049223.1:2000SEP08 g2907281 202 361 217 U:2049223.1:2000SEP08 4914013H1 1 255 218 LI:1177833.1 2000SEP08 5502992F6 717 1037 238 CO m NJ NJ NJ NJ NJ NJ NJ NJ -vJ NJ NJ N rO NJ NJ -N -vJ NJ NJ NJ NJ NJ NJ NJ M IvJ NJ -Nj NJ KJ NJ NJ rO -N NJ NJ NJ NJ K^ J KJ 5 W -O N M N M - W N M M M - N I M M - - - M M M -' -' - - -- - -^ -- -' -- -' -- -^ -- - ^ -' -' -' ^ W M I M K) - - - - - -' -' O O O O O O O O O O O ) -0 '0 '0 C0 C-3 C0 0) 00 0! 0! (» (» ffi α) 0) 00 00 0! 01 (( ) 01 CB 00 0 ) W (» σ O en NI _, cn oo oi cn ω ^ ,. _. ( . T1 CJ CJ CJ CJ NJ CJ J__ CJ — ■ ^- _ 00 Co J-- 4-- NJ _ cn vj co NI cn cn NI NJ en o O ≥ — ' ?£ — ' O Nl NJ 00 Nl 00 c j CJ ^^ o —O ' - ■ N N Oi j N- 0o0 ≤ S ∞ C | -- OO ) OO- O_, < t-- O 0 . -. i C N O ) 0 -. • S j -- ~— _ ■ ^ NI -fc-. NI CJ Nj Nl O J O — • NJ —■ NI O O NJ ONJ —' CJ _-_., cn Q_2 CO —■ to CJ ro CJ ro 7L NJ NJ NJ NJ NJ NJ NJ NJ NJ NJ NJ -O NJ NJ M NJ KJ -vJ NJ NJ NJ NJ NO O NJ - NJ NJ NJ NJ N r NJ NJ NJ NJ t KJ KJ IO NJ t NJ NJ NJ NJ NJ KJ tO NJ -O NJ KJ NJ NJ - -vJ NJ NO NJ W O- t ro r rO M NJ NJ t NJ KJ NJ NJ NJ NJ NJ KJ rO NJ NJ NJ r tO KJ I- -Nj tO NJ NJ 5^ 0 0 0 0 00 0 0 00 0 0 0 0 0 _^ _. ooooooooooooooo^τ ^ IO -^ r^ ^ ^ N^ [--ϊ S O OO O OO O O OO O O O O O Φ S O OO O OO O O OO O O O O O — g fπ oooooooooooooooπ _ π g O Q CD O O O P O O O O O O O O w en cn cj j . r -, cj c-x) e o o) -v _ 1 cn ιo c-ι o en o en c» Nj oo oo , oo ^ go r j NJ f n Co CJ _, I NI o 4_. ro NJ CJ en cB θ _-. s S ^ ^ "N ζ c o ^ o ej -θ Nj Ni Ni Ni θ Ni K -- fx e - ) o >c o S5 NJ Nl ^_ Nl O 00 NJ —■ —' .-_. 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CJ CJ C CJ CJ CJ CJ CJ C^ — CN C C C CN CN C CN CN C C CN C C CN CN C CN CN C CN C CN C CN C C o G o 90 r- fM o C O O O CM — UJ IN _ UJ CO — O — — ■ vT Cvl lN ^ n C fNri g ^ ■ — — o o f M vt (O r- CO — O UJ OO CM UJ t -i- JU o co oo oo o o o o w N vf ^ vf CM - O " 00 " C0 " — 8 —: CM 00 J CJ — CM CO ^ CN CN CN CM CN CN — CN u;) — Cvl CN CM CM CN CM CM CN CM CN CN CM CN CN CM CN — — — — C CN CN CN CN CN — — — CN CN CN CN CN CN CN C-N H U α. ό IN o Q c c CJ CO CJ CJ CJ CJ CJ C CJ C CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CO CJ CJ CO CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CJ CN CN CN CN CN CN CN CN C C CN CN C Csl CN C CN CN CN C CN CM C C CN CN CN CN C^ o O TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 231 LI:2050313.1 2000SEPO8 g1760607 1992 2359 231 LI.2050313.1 2000SEP08 71191657V1 1992 2629 231 Ll:2050313.1 2000SEP08 7659719J1 1994 2665 231 Ll:2050313.1 2000SEP08 g4889106 3344 3563 231 LI.2Q50313.1 2000SEP08 70697058V1 2435 2991 231 LI.2Q50313.1 2000SEP08 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Nl Nl NI Nl Nl NI NI Nl Nl NI Nl NI NJ Nj Nl -3 ^ --. -- -- - J ----, ^ --- --- J ---. --- J ----, -- J --. -J -J ---J -- J -- J ----, ---J -- -- -- -- -J -- -J -- -- -. -- -^ -O -vJ NJ -vj iv-J NJ NJ -J NJ N rvJ -J NJ -vj -vj § O O O O O Q Q Q O O O O O O O O O O O O O O Q O O O O O O O O O O O O O O O O O Q O O O O O O O O m " D Q Q Q O O Q O Q Q Q Q Q O O O O O O O O O O O O O O O O O O O O O O Q O O O O O O O O O O O O O lu b o o b o o o o o o o p o o o p p o o o o o o o o o o o o o o o o o o o o p o o p p p p o o p o o p; m m m m m m m m rπ m iTi rπ m m π m m m m m m -Ti m m rπ -Ti m m m m -Ti m m m m m m m m m m -Ti τ τ τ τ τ τ τ -σ τ τ τj -D τ τ τ τ τ τ -D τ -- τ -α 'O τj τ -D τ τj τ τ τj -α τ τ τ τ^ O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O CO 00 00 00 C» 00 00 00 C» 00 00 00 00 00 0- C» 00 00 (» 00 00 00 00 00 <» 00 C» 00 03 00 C0 00 00 00 0D » ~; Z- -0 O 00 Nl O O fc. fc. NJ NJ -- fc fc fc fc CJ CJ CJ — ■ en Ni en cn cn fc fc fc CJ C c cj c cn ? ^ ^ en — ■ cn oo oo fc K — ' fc o o — ' fc CJ IO N Nl fc fc OO — ■ — ' O fc C CJ — ' fc Co — ' 00 00 00 00 — ' Q ro KJ co K io ej N NJ CJ N ≥ ≥ fc Nl OO O NJ O O fc O fc -' en — ' Cn cj — ' O to en en cn o — ■ — ' Cn cj — ' O o o o en CO _£ fc fc fc fc fc CJ fc fc CJ fc f Co CJ CJ O —' o Nj cn en Ni co Ni o e Un1 OU- NNiI — — - ■ c_vol t|Vo r -. r - oHJ oNJ o-u - OU U O- 00 o vi vi oo oo en N) K) ( ) N) N) N) ' ( ) -<> c M Nl --^ OC _J NJ Ni oo f c c fc oo o Nj y y fc o o o " o c " -D VI fc ro en oo vi KJ ω O — O — « fc fc fc CO 00 O CO CJ 00 Nl Nl c o — • vi _ . - - -- - o o o NJ CJ en o fc o -* - ■ fc ro — ■ — o ro fc oo o o fc o cn g S δJ NJ -' fc — ■ O cn ro oo oo oo o to OT o O 00 CM t-. CM O CΛ g O-o CN o CM vt H U α. t CM CM N CM CM CN CJ CJ CN CN CJ UJ O O O O — — ιn ιO - ) ιQ -Q t κ E f — — — 00 — O OO — — OO O O CN UJ UJ IN O O CO 55 — — — — — — — — — — — O O O O — CM CN UJ UJ UJ UJ UJ O oo S — — O O O rv CJ CJ CJ CJ CJ O — CJ t vJ O O UJ CM O • Nt c c cj u u uj u uj uj uj uj o -o l^: — — — — CN CM CJ vt t vt LO UJ UJ UJ UJ -N CO OO OO n — m ii 0 Q. C Φ i— O O O O O O O O O O O O O O O O O O O vt t t N vt TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 240 1-1:1183147.3-2000SEP08 6560934T8 879 1494 240 1-1:1183147.3-2000SEP08 6560934H1 880 1451 240 1-1:1183147.3-2000SEP08 6560934F8 880 1603 240 1-1:1183147.3.2000SEPO8 2844761 HI 887 1147 240 1-1:1183147.3-2000SEP08 1832094H1 935 1025 240 1-1:1183147.3-2000SEP08 g1300493 1073 1487 240 1-1:1183147.3-2000SEP08 1007614m 595 776 240 1-1:1183147.3-2000SEP08 1401826F6 630 1115 240 LI:1183147.3:2000SEP08 1401826H1 630 876 240 1-1:1183147.3-2000SEP08 1333095F6 632 949 240 1-1:1183147.3-2000SEP08 70651793V1 690 1236 240 1-1:1183147.3-2000SEP08 70649650V1 706 1269 240 LI:1183147.3:2000SEP08 2597282T6 1329 1606 240 LI:1183147.3:2000SEP08 g6041091 1329 1598 240 LI:1183147.3:2000SEP08 g3803626 1329 1602 240 LI:1183147.3:2000SEP08 g4990175 1362 1598 240 LI:1183147.3:2000SEP08 g4890819 1146 1602 240 LI:1183147.3:2000SEP08 196640R6 1 205 241 LI:1175373.3:2000SEP08 70394043D1 245 647 241 LI:1175373.3:2000SEP08 70503364V1 9 417 241 1-1:1175373.3:2000SEP08 70392349D1 21 557 241 LI:1175373.3:2000SEP08 70393943D1 215 521 241 LI:1175373.3:2000SEP08 70503499V1 35 722 241 LI:1175373.3:2000SEP08 60217417D1 39 230 241 LI:1175373.3:2000SEP08 70497402V1 281 581 241 LI:1175373.3:2000SEP08 7312966H1 317 725 241 LI:1175373.3:2000SEP08 6772905J1 1 603 241 LI:1175373.3:2000SEP08 2189954H1 9 279 241 LI:1175373.3:2000SEP08 70502455V1 9 578 241 LI:1175373.3:2000SEP08 2189954F6 9 365 241 LI:1175373.3:2000SEP08 60217438D1 12 329 241 LI:1175373.3:2000SEP08 60217436D1 16 346 241 LI:1175373.3:2000SEP08 60217437D1 18 346 241 LI:1175373.3:2000SEP08 70355479D1 332 593 241 LI:1175373.3:2000SEP08 70393236D1 213 647 242 1-1:813757.1 2000SEP08 70250012V1 7 394 242 Ll:813757.1 2000SEP08 70247960V1 114 615 242 1-1:813757.1 2000SEP08 70248697V1 235 565 242 1-1:813757.1 2000SEP08 70250218V1 161 693 242 -.1:813757.1 2000SEP08 70250104V1 120 722 242 1-1:813757.1 2000SEP08 70250824V1 142 721 242 1-1:813757.1 2000SEP08 70250254V1 221 716 242 Ll:813757.1 2000SEP08 70249632V1 157 707 242 1-1:813757.1 2000SEP08 70247802V1 59 589 242 1-1:813757.1 2000SEP08 70251286V1 588 242 1-1:813757.1 2000SEP08 3449946R6 577 242 1-1:813757.1 2000SEP08 70251559V1 210 580 242 LI:813757.1 2000SEP08 70251049V1 549 242 LI:813757.1 2000SEP08 70247407V1 535 242 LI:813757.1 2000SEP08 70251324V1 532 257 - IO NJ NJ NJ NJ tO lv rO NJ IO IO IO NJ -- I I -O M IO r I N NJ NJ IO KJ NJ I I fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc m CJ C-J CJ C-J C-J CJ C-J CJ CjO CJ Co CJ C-J C-J C-J CJ C-J C-J C-J CjJ CJ CJ CJ CJ -O NJ I^ 0 vl O o o o o o _- o o o o o O o O o o ro ro to o o O O o o o ro κ> ro ro o ° o o fc o o o m o o en en fc en en fc fc oo o en en fc fc en fc fc o fc fc ro en en fc ro ro ro f f fc en o en o o o o o c fc c Ό f o en o o o fc f o o O o e ----n---- c ro c £ en — _ o — - c en o en o en fc en - o o o f o o en en — o 8 v8 fc cn o en fc o fc cf o o o _ o o o to to o fc fc o en fc fc1 o §s <3±<<<±< < < < < < < < < < < < < < < < < < < < < < X o en o o < < < < < < < < ≥ o < < X o o o fc ~ << < < < < < -. D cj fc Ni o fc co cn c cj o co fc — ■ cn o co - en ro co NJ fc fc fc Nl 0 o. 0cn- 0o —— - ' O -NvjJ oO —— - ' oO. cCn NNii ccnn .-oo ccjj o e cnn o S NJ — i c enn CJ o NI __ _ CO - ? ° O O O NJ — ■ — ■ — ■ fc co o ro Q IO — ■ vi vi — ' fc N o o oo o- oo en & 00 o fc cn en NI CJ 3 - 5 7L O VI oo oo oo O _ O _ O _ O O OO OO NI fc Nl O O o o oo Ni c O Ni fc en fc en o NJ o o fc o en fc NI NI o _ o-- ,-- — ■ NJ KJ fc fc en en o?. -TO N O vJ I- M U W - N -i N -i o - c -n c _π- o _ fc . c -n o _ Ni co o o -v -v o fc o en co — ' vi o — • — ' fc NI NJ O OO O O C^J NI O CJ O OO OO O — ' O oo o Ni to fc oo oo NJ K Ni en en cj fc fc Ni Nj ej O NJ - Ni fc o oo cj o fc cn — ' ivj cn — ' fc o NI -- CO CO — > — • cn , o r , cn fc cf cn o o o o- -_3 pe I D T em l a t N r NJ ro ro rO I NJ rO NJ NJ NJ NJ NJ NJ NJ - - NJ KJ NJ IO NJ NJ NJ NJ NJ NJ NJ NJ I NJ NJ NJ NJ NJ NJ NJ NJ N^ fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc cn cπ cn en en en en en cπ en en cn cπ cn cn en cn cn en cn en en Sfcfcfcfcfcfcfcfcfcfcfcfcfcfcfcfcfcfcfcfcfc co — < -- —. —. —. --. fc --- co ιo ro — ' Co co — ■ — ■ — ■ — ' CJ o - o - rj r-j Ni — , CO CJ NJ ,.„ NJ O O O Nl fc CJ Co fc — ■ CJ CJ CJ CJ CJ CJ CJ OO CJ CJ 0"6 — ' O - O_ C-.J- fc- C -J . — ' Nl . C -J - CJ CJ fc - Nvli C ( -J- | ( c- j ~ ; - Λ ; r Λ r ^- ) < c J x-i — ' O 0O0 Ni iN, -- ■ K. c —. j^ jv. cj o c — - cn oo — ■ ■ tO fc fc fc fc Nl fc CJ fc tO Nl Ni i oo ro N NJ O — K j e N Co fc S S cn S 0 0 ' en ro =: fc fc ro o oo ro o ro o fc - g en cn cn en cn en en cn cn cn en oo s cn cn cn o cn cn en en o o Ni Ni Ni oo oo oo oo oo o oo oo oo — ■ o - - o - c-- cS ^ ^ cj ∞ w ω -N- - io ^ w g g ' o e e j o o fc Nj o o N ιo_ rtσ Sfc ∞oo oo 0 , c, 0 <. O - J θ M ^ c N fc C oo < jJ θ -0 cn cn v0 i g^ v ^ j ^^ g ' ^ N J i c( _ no . ω -_ <, 0 j 1 .- 0 W ro gro Nj N c j o rø.c evni τo_j IvJ NJ NJ ro rO NJ tO IO IO IO IvJ tO -O I NJ IO IO IO fO NJ -O NJ IO NJ NJ NJ NJ -vJ NJ I l^ fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc o o o O O o o o O o o o o o o O o o o o o o o o o o O o O o o o o o o o o O o O O o cn cn en cn en en en fc fc fc fc CJ co ro J to to NJ NJ f o _ 00 , oenencnen-ooo y_^?_^Oofcfcfcc -_-- _ CJ cf -■ -■ o o .N _J N .I o - e -n- fc c ooo^--- fNJ ' _-- O N S O N S N CO - Λ cn fc CO CJ Q to o O Ni cj cn fc ro cn KJ 00 CO ^ -O300I OC-1 (,l fe c, ' ω O OC-lC-lC--0 ' Jl M , s, α> 3S o o ro fc _J. ro co o- fc fc cn cn OJ N α S-Ji SCϋJi cf Oi N CJ ω O & fc ToJ CΛ m NJ NJ NJ NJ -O -vJ t IO NJ M NJ -O NJ NJ NJ NJ M NJ NJ I NJ NJ KJ NJ NJ NJ NJ KJ I NJ NJ NJ NJ -O KJ KJ NJ NJ KJ I NJ W fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc fc M _2 - o • & & - cj co fc Nj en en en en en en en en en en --. oo ∞ oo oo c--o oo c--o c--θ Nj Ni Nj Nj Nj o o o o o o c-n en ςn en ci cn c-n fc fc fc --H o fc § 9 rn O - CO Nl o — rO KJ NJ NJ KJ tO KJ IO tO ej — ' Cn en en en cn fc -vj — ' O oo o fc — ' Ni Ni fc co c co Ni fc fc fc Nj o o o o Q o o ^ c" oo oi to ω o O O NJ KJ KJ OO fc tO O — ' fc t 00 θ Nj _- CJ θ fc NJ O O O fc 00 O O _;. ro to ω fc CJ Cj e o o Ni cj S fe ^ a o r en cn e fc ^ cj cj o ω - o o cj ω No - -- -- z ~ oo __: __ co oo __, o NJ n o o -¥ g fc O N ^ N O O ^ j^ ^ g Nj fc O fc NJ fc ^ W - - -O -O C^ -O ^ Nl C OO NJ O "- -- - - -- o N -- Nl oo NJ i en o c o o ooo n σ — o ■ r ^ o y o o o W O- '0 -' N -0 -O t- fc ^ < ti M O ' ω fi ϋ ' vl ^ -ι -0 - N O) 0 -ι O I C- t -- 0 o ro N w fc -o «XS r- o Q. O O ιO r N i CN c '^ θ N j o l N θ ιθ r N θO t O '^ 0 O O C r -, ιr v rn vτr _o -Nj -^ O IN O 00 o O co . cN O O O i Λ i O CN - c .- '- '- cO N O CN .- o S ≤ π & rt o rj S ΓN ΓN o IN CO CN CM CM CM CM CM CM CM CM CM CM CM — H U α. 0g0 Og0 0g0 0g0 0g0 0g0 0g0 Cg0 0g0 020 020 020 020 020 020 C2O 0g0 0g0 0g0 CgO 0g0 0g0 0g0 CgO 0g0 0g0 CgO 0g0 0£0 0£0 C£O 0£0 αgJ Cg0 0g0 0g0 0£0 020 00 00 00 00 00 00 C0 m ^ ^ L±i w w w w w w w w w w w i-u w w w w w w w uj ijj w w w u w £2gggggo§888 Ω . !O-) (O-JO-Λ WO(O-lO(Λ WOOIΛ WO(OWO(O-J (O-J !OO IO-J WOO--J WOnO(OgO-Λ (Ofl WOO--J CO) (OΛ W (Λ W n (-J W O CO CO — O O O O O O O O O O O O O O O O O O O O O O O O O OOOOOOOOOOOOOOOOOOOOOO O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O OO O OOOOO O OO O OOOOOO O OO O SQRSQ CJ CD O O OO O HS S 0 0 ■ J= CM CN < CM CM CN CN CM CM ( C CN C C CN CN C^ CN CM CN n ^ ^ ^ ^ ^ ^- ^ ^ r ^ ' _ '~ '- '~ , " ^ ^ r r . , " r . r '- r r r r r r . '- r r r r r : r r r r : r r r r r r r v v t t t E O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O i^ * ! ^" C -O CO CO CO CO CO CJ CO CO CO CO CO CO C CO CO CO C CO CO CO O CO CO C CO CO CO CO OO CO CO CO M IN IN φ N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N X ?; CO CO O l_ϊ ( C (>l ( Cvl C C CN CM C CN CN CN CN CN CN CN (-N CN C CN < CN CN CN C ( CN C CN CN C^ 0 0 CO OD O0 00 00 OD 00 00 0O 0O 0O 0θ αD _0 0O 0O 0O 00 00 OO 0O 0O _0 OO _0 -0 0O _D _0 0O 0O O0 0O OO OO OO 0O OO 0O CO 0O 0O 0O 0O t "vt • vt O C CO , I ^ ^ -Z ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ :z :z ;z ^ ;__ ^ ^ ^ ^ :__ :__ ^ ;----: ^ ^ ^ ;Z CM CN CN CN CN o r- z o Q vt o O TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 248 U:234937.4:2000SEP08 6201371 HI 28 589 248 U:234937.4:2000SEP08 6444066H1 86 619 248 U:234937.4:2000SEP08 70170335V1 88 512 248 LI:234937.4:2000SEP08 70199890V1 103 612 248 LI:234937.4:2000SEP08 6951283H1 119 554 248 LI:234937.4:2000SEP08 5400740H1 147 415 248 LI:234937.4:2000SEP08 971204R6 164 574 248 LI:234937.4:2000SEP08 971204H7 164 475 248 LI:234937.4:2000SEP08 60210282U1 315 883 248 U:234937.4:2000SEP08 70197633V1 381 680 248 LI:234937.4:2000SEP08 70165167V1 204 493 248 LI:234937.4:2000SEP08 70166455V1 210 680 248 U:234937.4:2000SEP08 70168325V1 207 490 248 LI:234937.4:2000SEP08 5900730H1 216 482 248 LI:234937.4:2000SEP08 71704061V1 249 423 248 LI:234937.4:2000SEP08 70200163V1 268 716 248 LI:234937.4:2000SEP08 70199868V1 284 711 248 LI:234937.4:2000SEP08 70165466V1 286 698 248 LI:234937.4:2000SEP08 70200075V1 297 796 248 LI:234937.4:2000SEP08 70199839V1 309 674 248 LI:234937.4:2000SEP08 70199994V1 314 744 248 LI:234937.4:2000SEP08 2815595H1 313 584 248 LI:234937.4:2000SEP08 971204H1 164 427 248 LI:234937.4:2000SEP08 5907378H1 177 434 248 LI:234937.4:2000SEP08 70200111V1 182 708 248 LI:234937.4:2000SEP08 6439781 HI 198 708 248 LI:234937.4:2000SEP08 70169923V1 386 666 248 LI:234937.4:2000SEP08 70200182V1 391 835 248 LI:234937.4:2000SEP08 4245558H1 421 665 248 LI:234937.4:2000SEP08 984607H1 440 753 248 LI:234937.4:2000SEP08 4194365H1 442 750 249 LI:1170660.1 2000SEP08 7582236H1 1 568 249 LI:1170660.1 2000SEP08 60218360D1 45 533 249 LI: 1170660.1 2000SEP08 60218356D1 69 309 249 LI: 1170660.1 2000SEP08 5547632H1 223 419 249 LI:1170660.1 2000SEP08 7186676H1 223 780 249 LI: 1170660.1 2000SEP08 4706707H1 229 494 249 LI:1170660.1 2000SEP08 4543751 HI 229 492 249 LI:1170660.1 2000SEP08 g1635530 251 552 249 LI:1170660.1 2000SEP08 g1230443 257 449 249 LI:1170660.1 2000SEP08 60218359D1 264 759 249 LI: 1170660.1 2000SEP08 172943H1 324 547 249 LI:1170660.1 2000SEP08 60218364D1 513 923 249 LI:1170660.1 2000SEP08 4572811 HI 588 716 249 LI:1170660.1 2000SEP08 7328676H1 604 1045 249 LI:1170660.1 2000SEP08 g706516 643 871 249 LI:1170660.1 2000SEP08 g883656 644 1014 249 LI:1170660.1 2000SEP08 3806727H1 649 774 249 LI:1170660.1 2000SEP08 g675102 664 1020 249 LI:1170660.1 2000SEP08 60218358D1 851 1293 263 00 UJ O 3 CN O O . c CN M | C - « ( q- i r N_ -t r -N OO C-O t -— UJ CO O -N O i— CO CN CO OO r— -— m m Λ m m m Λ K 0 π ^ -) - N . ιo io -) in N N o >o - g - <) " 2 S 55 S 5 ^ ιo ^ c- c. iv O O O IN IN CN -N OO CN CM r— O i— IN CN CM CM i— O O J o o O CM CO O O- r— <— CD r— CO ' vt O O O UJ CM CO °C' cN CN CN CN CN CN CN '— -— CN CN CM CN CN r - -— -— U U U OO OO OO OO __ CO CO CO CO vt vt CO c O t t UJ ccO cO cO O O O cO t o r- z o Q O O O O O O O O OO O O O O O O O O O O O O OO Q O O O O O OOOO O O O OO O O O O Q OO O O O UJ LO LO LO LO LO LO LO LO LO LO UJ LO LO LO LO LO LO UJ LO LO IO UJ IO I-J IO IO LO LO LO LO LO IO UJ LO UJ UJ LO LO LO IO L^ CN CN ( CN CN CN CN CN CN CN CN CN CN ( CN CN CN C CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN CN C^ o G o 00 fM fM O o. ( iθ vf ) ) c - N () -) θ N vt Nt -) v' N g c- vr g ι. ^ (θ v' r- c. N o g g ι- θ' ) 3 ^ p- _; (> ι . - ) - θ ( . O -. . rv_ o. --^ ^ ._ ^ c ^ ^ ^ __- -J ->- O_ ^ CM C0_ C0_ 0 c t ιΛ O _ , v. ι O_ 'vt O„ CM O_ -N -— O IN UJ IV iv CΛ V- -~ -r. --.. .--. - 3-.. _ - O-- . O--. .- ^t -= c u-j t c t O LO ' t o rN rN J _ IN "t~ " IN IN " IN C —O " -N O -O c—O O- —t ■ -O- -U-J v —t l -N -iN -iN -— -— - - - ■ - IN _t C-M. c —O C —O C -O- C-N. i.O_ _t-. -O cO O — CN CN CN CN CN CN CN — — — CN CN — — CN CN — CN CN CN CN CM CN CN CN CN CN o r CvO H U α. 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CO C CO CO C CO CO C CO CO C CO C CO C C CO C CO CO C CO CO CO W Q —OooO OoOoOoOoOoOoOoOoOoOoOoOoOoOoOoOoOoOoOooO OoOoOoOoOoOooO OoOoOoOoOoOoOoQδOoOoOoOpOoOoQδOoOoOoOoOoOo φoooooooooooooooooooooooooooooooooooδooooδooooooooo ■ £ CN CN CN C CN CN CN CN CN CN -N CN CM CN CN CN < CN CM CN CN CN CN C CN CN CM CN CM CN CN CN ^ECoOoOoOo0oo00oOoOoOo0o OooOOoOoOoOoOoOoOoOoOoOoOoOoOoOoOoOooooooooooooooooooooooooooooooooooooooo'-:^o — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — r- — — — — — — — — — — r- — t -Nt — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — r- — — — — — — CN CN o r- o O O O O O O O O O O O OO OOOO O OO O O OO O O O O O OO O Q OO O OO O OOO Q O O O O — — IO LO L LO L L L L L !O I LO L IO I LO L L L LO LO L U L 1 10 LO IΛ IO UJ LO L CN CN CN CN CN ( CN CN CN CN CN CN CN (N CN CN CN CN CN CN CN CN CN CN CN CN CN CN ( CN CN CN C^ o o TABLE 5 SEQ ID NO: Template ID Component ID Start Stop 251 Ll:246290.10:2000SEP08 7644139J1 512 1059 251 U:246290.10:2000SEP08 6723259H1 516 916 251 U:246290.10:2000SEP08 747973R6 330 859 251 U:246290.10:2000SEP08 747973H1 330 572 251 LI:246290.10:2000SEP08 7170570H1 383 910 251 U:246290.10:2000SEP08 5080008H1 88 328 251 U:246290.10:2000SEP08 5957953H1 89 545 251 LI:246290.10:2000SEP08 6937991 HI 99 200 251 U:246290.10:2000SEP08 7168155H1 137 243 251 U:246290.10:2000SEP08 4831526F8 229 767 251 U:246290.10:2000SEP08 4831526H1 230 359 251 U:246290.10:2000SEP08 4831526F9 229 744 251 U:246290.10:2000SEP08 7387420H1 285 504 251 U:246290.10:2000SEP08 5761576H1 540 807 251 U:246290.10:2000SEP08 4930979H1 612 891 251 LI:246290.10:2000SEP08 806868H1 728 958 251 U:246290.10:2000SEP08 6866060H1 68 403 251 U:246290.10:2000SEP08 3506257H1 73 350 251 LI:246290.10:2000SEP08 3550395H1 1 288 251 LI:246290.10:2000SEP08 7988114H1 2 511 251 LI:246290.10:2000SEP08 3316757H1 18 304 251 U:246290.10:2000SEP08 8122994H1 19 612 251 U:246290.10:2000SEP08 5457648H1 23 233 251 U:246290.10:2000SEP08 3508411 HI 23 303 251 U:246290.10:2000SEP08 3577541 HI 23 287 251 U:246290.10:2000SEP08 5460535H1 23 271 251 LI:246290.10:2000SEP08 7002420H1 39 596 251 U:246290.10:2000SEP08 4328953H1 42 304 251 U:246290.10:2000SEP08 3973335H1 57 325 251 U:246290.10:2000SEP08 7470753H1 67 633 251 LI:246290.10:2000SEP08 2966230H1 1 297 251 LI:246290.10:2000SEP08 2966230F6 1 377 252 Ll:280034.1 2000SEP08 8045415H1 1 646 252 Ll:280034.1 2000SEP08 8045415J1 482 1096 252 Ll:280034.1 2000SEP08 681866T6 584 802 252 Ll:280034.1 2000SEP08 681866H1 584 845 252 Ll:280034.1 2000SEP08 681866R6 584 841 252 Ll:280034.1 2000SEP08 4936924H1 781 1020 266 TABLE 6 SEQ ID NO: Template ID Tissue Distribution 1 LG:150318.1:2000SEP08 Nervous System - 100% 2 LG:022529.1:2000SEP08 Musculoskeletal System - 25%, Unclassified/Mixed - 22%, Cardiovascular System - 14% 3 LG:352559.1:2000SEP08 Unclassified/Mixed - 67%, Digestive System - 33% 4 LG:175223.1-2000SEP08 Embryonic Structures - 82%, Nervous System - 18% 5 LG:476989.1:2000SEP08 Exocrine Glands - 62%, Urinary Tract - 31% 6 LG:253268.7:2000SEP08 Germ Cells - 56%, Nervous System - 23% 7 LG:401322.1:2000SEP08 Sense Organs - 50%, Liver - 17%, Skin - 13% 8 LG:1328436.1:2000SEP08 Respiratory System - 38%, Endocrine System - 35%, Connective Tissue - 27% 9 LG:475404.1:2000SEP08 Skin - 81% 10 LG: 1384132.1.-2000SEP08 Respiratory System - 50%, Digestive System - 33%, . Nervous System - 17% 11 LG:410804.18:2000SEP08 Nervous System - 100% 12 LG:1082306.1:2000SEP08 Cardiovasculor System - 28%, Digestive System - 21%, Exocrine Glands - 14%, Endocrine System - 14% 13 LG:233814.4:2000SEP08 Endocrine System - 36%, Pancreas - 36%, Exocrine Glands - 16% 14 LG:977478.5:2000SEP08 Cardiovascular System - 34%, Musculoskeletal System - 19%, Female Genitalia - 16% 15 LG:025931.1:2000SEP08 Female Genitalia - 29%, Urinary Tract - 24%, Endocrine System - 24% 16 LG:885368.1:2000SEP08 Nervous System - 67%, Female Genitalia - 33% 17 LG:1054900.1:2000SEP08 Digestive System - 50%, Female Genitalia - 25%, Male Genitalia - 25% 18 LG:995186.2:2000SEP08 Digestive System - 67%, Nervous System - 33% 19 LG:435048.23:2000SEP08 Urinary Tract - 80%, Nervous System - 20% 20 LG:954859.1:2000SEP08 Embryonic Structures - 56%, Hemic and Immune System - 19%, Female Genitalia - 13%, Nervous System - 13% 21 LG:364370.1:2000SEP08 Liver - 90%, Male Genitalia - 10% 22 LG:1098789.1:2000SEP08 Urinary Tract - 100% 23 LG:201540.2:2000SEP08 Unclassified/Mixed - 15%, Female Genitalia - 13%, Connective Tissue - 13%, Male Genitalia - 13% 24 LG:1077357.1:2000SEP08 Nervous System - 43%, Male Genitalia - 29%, Female Genitalia - 29% 25 LG:1048846.4:2000SEP08 Female Genitalia - 25%, Digestive System - 25%, Male Genitalia - 25% TABLE 6 ID NO: Template ID Tissue Distribution 6 LG:336685.1:2000SEP08 Hemic and Immune System - 35%, Urinary Tract - 24%, Male Genitalia - 7 LG:1076253.1:2000SEP08 Liver - 50%, Urinary Tract - 1 1%, Endocrine System - 11% 8 LG:1400601.2:2000SEP08 Skin - 100% 9 LG:1079092.3:2000SEP08 Musculoskeletal System - 100% 0 LG:1086064.1:2000SEP08 Skin - 69% 1 LG:1400608.1:2000SEP08 Female Genitalia - 26%, Urinary Tract - 21%, Respiratory System - 16% 2 LG:399275.5:2000SEP08 Respiratory System - 50%, Male Genitalia - 33%, Hemic and Immune System - 17% 3 LG:293943.1 :2000SEP08 Exocrine Glands - 50%, Digestive System - 25%, Hemic and Immune System - 13%, Nervous System - 13% 4 LG:345884.1:2000SEP08 Respiratory System - 63%, Hemic and Immune System - 38% 5 LG:400967.1:2000SEP08 Embryonic Structures - 36%, Urinary Tract - 28%, Cardiovascular System - 16% 6 LG:024556.6:2000SEP08 Nervous System - 89%, Male Genitalia - 11% 7 LG:081189.3:2000SEP08 Germ Cells - 88% 8 LG:018258.1:2000SEP08 Digestive System - 44%, Endocrine System - 44%, Hemic and Immune System - 1 1% 9 LG:450399.3:2000SEP08 Nervous System - 100% 0 LG:451122.1 -2000SEP08 Nervous System - 100% 1 LG:451682.1:2000SEP08 Nervous System - 100% 2 LG:238631.4:2000SEP08 Uver - 17%, Endocrine System - 14%, Respiratory System - 1 1%, Male Genitalia - 1 1% 3 LG:236654.1:2000SEP08 Unclassified/Mixed - 38%, Respiratory System - 15% 4 LG:332655.1:2000SEP08 Pancreas - 26%, Digestive System - 17%, Female Genitalia - 13% 5 LG:217396.2:2000SEP08 Skin - 24%, Embryonic Structures - 15%, Pancreas - 15% 6 LG:090574.1:2000SEP08 Respiratory System - 100% 7 LG:202943.1:2000SEP08 Embryonic Structures - 44%, Female Genitalia - 19%, Liver - 14% 8 LG:236928.1:2000SEP08 Unclassified/Mixed - 15%, Hemic and Immune System - 14%, Nervous System - 12% 9 LG:215169.2:2000SEP08 Endocrine System - 22%, Unclassified/Mixed - 20%, Nervous System - 20% TABLE 6 SEQ ID NO: Template ID Tissue Distribution 50 LG:410726.1:2000SEP08 Embryonic Structures - 38%, Pancreas - 24%, Endocrine System - 18% 51 LG:234372.2:2000SEP08 Stomatognathic System - 17%, Germ Cells - 12%, Musculoskeletal System - 1 1% 52 LG:022629,1:2000SEP08 Unclassified/Mixed - 36%, Germ Cells - 28% 53 LG:068682.1:2000SEP08 Unclassified/Mixed - 61%, Male Genitalia - 20% 54 LG:222335.1:2000SEP08 Musculoskeletal System - 27%, Exocrine Glands - 17%, Male Genitalia - 13% 55 LG:331342.1:2000SEP08 Male Genitalia - 35%, Digestive System - 22%, Endocrine System - 20% 56 LG:021770.1:2000SEP08 Pancreas - 18%, Exocrine Glands - 14%, Nervous System - 12%, Urinary Tract - 12%, Male Genitalia - 12% 57 LG:181607.9:2000SEP08 Musculoskeletal System - 25%, Cardiovascular System - 22%, Embryonic Structures - 18% 58 LG:1042768.1:2000SEP08 Uver - 100% 59 LG:282729.1:2000SEP08 Skin - 74%, Unclassified/Mixed - 21% t σv 60 LG:998305.3:2000SEP08 Urinary Tract - 50%, Cardiovascular System - 29%, Nervous System - 21% ^_> 61 LG:1135213.1:2000SEP08 Embryonic Structures - 26%, Cardiovascular System - 20%, Digestive System - 1 1%, Unclassified/Mixed - 11% 62 LG:267762.1:2000SEP08 Cardiovascular System - 16%, Urinary Tract - 14%, Connective Tissue - 14% 63 LG:120744.1:2000SEP08 Skin - 35%, Embryonic Structures - 23%, Digestive System - 20% 64 LG:403409.1:2000SEP08 Stomatognathic System - 45%, Respiratory System - 12% 65 LG:226874.3:2000SEP08 Respiratory System - 38%, Male Genitalia - 35%, Female Genitalia - 19% 66 LG:1045521.4:2000SEP08 Germ Cells - 16% 67 LG:275876.1:2000SEP08 Unclassified/Mixed - 53%, Endocrine System - 27%, Nervous System - 20% 68 LG:475127.7:2000SEP08 Hemic and Immune System - 75%, Nervous System - 25% 69 LG:157263.1:2000SEP08 Embryonic Structures - 39%, Urinary Tract - 30% 70 LG:247382.7:2000SEP08 Urinary Tract - 19%, Hemic and Immune System - 13%, Embryonic Structures - 13%, Endocrine System - 13% 71 LG:197367.5:2000SEP08 Endocrine System - 100% 72 LG:218090.5:2000SEP08 Unclassified/Mixed - 42%, Urinary Tract - 21%, Exocrine Glands - 21% 73 LG:216612.4:2000SEP08 Nervous System - 45%, Digestive System - 30%, Endocrine System - 20% TABLE 6 SEQ ID NO: Template ID Tissue Distribution 74 LG:197614.12000SEP08 Germ Cells - 17%, Unclassified/Mixed - 16% 75 LG'37842812000SEP08 Liver - 30%, Endocrine System - 15%, Embryonic Structures - 15% 76 LG 28663912000SEP08 Germ Cells - 72% 77 LG:389870.12000SEP08 Liver - 41%, Nervous System - 23%, Cardiovascular System - 18%, Endocrine System - 18% 78 LG-13874856'2000SEP08 Female Genitalia - 16%, Digestive System - 14%, Urinary Tract - 13% 79 LG 23015112000SEP08 Exocrine Glands - 16%, Urinary Tract - 14%, Liver - 12%, Pancreas - 12% 80 LG_1515852000SEP08 Liver - 13%, Nervous System - 12%, Unclassified/Mixed - 1 1% 81 LG:23584012000SEP08 Connective Tissue - 13%, Nervous System - 12%, Hemic and Immune System - 1 1%, Liver - 1 1% 82 LG.350272.12000SEP08 Germ Cells - 17%, Musculoskeletal System - 15% 83 LG 23219012000SEP08 Liver - 24%, Unclassified/Mixed - 23%, Skin - 19% 84 LG:1068127.1:2000SEP08 Hemic and Immune System - 43%, Male Genitalia - 29%, Nervous System - 29% t 85 LG.40875132000SEP08 Nervous System - 43%, Sense Organs - 31% Nl o 86 LG:1078933.V2000SEP08 Liver - 23%, Unclassified/Mixed - 20%, Nervous System - 13% 87 LG 958731.12000SEP08 Nervous System - 100% 88 LG 02412552000SEP08 Connective Tissue - 17%, Embryonic Structures - 16% 89 LG 37363732000SEP08 Unclassified/Mixed - 73%, Male Genitalia - 23% 90 LGl053229.1:2000SEP08 Cardiovascular System - 50%, Embryonic Structures - 41% 91 LG 24836412000SEP08 Sense Organs - 48%, Female Genitalia - 17% 92 LG 47713012000SEP08 Nervous System - 100% 93 LG:113786.172000SEP08 Hemic and Immune System - 100% 94 LG:347635.12000SEP08 Musculoskeletal System - 45%, Female Genitalia - 17%, Urinary Tract - 14% 95 LG 24296642000SEP08 Germ Cells - 23%, Stomatognathic System - 23% 96 LG.217814.12000SEP08 Skin - 25%, Liver - 16%, Unclassified/Mixed - 15% 97 LG 476452.12000SEP08 Nervous System - 100% 98 LG' 1100657 V2000SEP08 Liver - 100% 99 LG113241822000SEP08 Cardiovascular System - 100% 100 LG-109857012000SEP08 Uver - 100% TABLE 6 SEQ ID NO: Template ID Tissue Distribution 101 LG:1097987.1:2000SEP08 Embryonic Structures - 41%, Musculoskeletal System - 27%, Female Genitalia - 23% 102 LG:337818.2:2000SEP08 Digestive System - 35%, Liver - 13%, Female Genitalia - 10% 103 LG:1040582.1:2000SEP08 Liver - 38%, Pancreas - 38%, Cardiovascular System - 17% 104 LG:1099122.1:2000SEP08 Liver - 96% 105 LG:1327449.1:2000SEP08 Endocrine System - 40%, Respiratory System - 30%, Digestive System - 20% 106 LG:227933.5:2000SEP08 Male Genitalia - 33%, Nervous System - 21%, Female Genitalia - 15% 107 LG:1043709.2:2000SEP08 Liver - 100% 108 LG:1099871.1 :2000SEP08 Liver - 90%, Nervous System - 10% 109 LG:1399139.4:2000SEP08 Unclassified/Mixed - 30%, Male Genitalia - 26%, Musculoskeletal System ■ 22% 110 LG:236386.1:2000SEP08 Skin - 16%, Connective Tissue - 13%, Pancreas - 10% 111 LG:1015157.1:2000SEP08 Liver - 100% 112 LG:1065433.1:2000SEP08 Female Genitalia - 50%, Endocrine System - 40%, Nervous System - 10% 113 LG:236992.4:2000SEP08 Connective Tissue - 64%, Urinary Tract - 12%, Cardiovascular System - 12% 1 14 LG: 1071 124.1.2000SEP08 Unclassified/Mixed - 22%, Cardiovascular System - 22%, Urinary Tract - 19% 115 LG:206425.2:2000SEP08 Sense Organs - 39%, Female Genitalia - 10% 116 LG:885747.2:2000SEP08 Female Genitalia - 100% 117 LG:1140501.1:2000SEP08 Sense Organs - 20%, Nervous System - 15% 118 LG:001239.1:2000SEP08 Hemic and Immune System - 35%, Uver - 17%, Male Genitalia - 13% 119 LG:018980.1:2000SEP08 Unclassified/Mixed - 52%, Urinary Tract - 12%, Nervous System - 12% 120 LG:1083120.3:2000SEP08 Digestive System - 50%, Hemic and Immune System - 25%, Nervous System - 25% 121 LG:233258.3:2000SEP08 Germ Cells - 25%, Female Genitalia - 12% 122 LG:999062.1:2000SEP08 Nervous System - 100% 123 LG:887776.1:2000SEP08 Cardiovascular System - 35%, Skin - 33%, Hemic and Immune System - 14% 124 LG:1400301.2:2000SEP08 Exocrine Glands - 50%, Connective Tissue - 44% 125 LG:1329362.1:2000SEP08 Unclassified/Mixed - 44%, Urinary Tract - 22%, Exocrine Glands - 22% TABLE 6 SEQ ID NO: Template ID Tissue Distribution 126 LG:1096498.1 :2000SEP08 Liver - 100% 127 LG:1096337.1:2000SEP08 Urinary Tract - 40%, Exocrine Glands - 40%, Nervous System - 20% 128 LG:1400579.1 :2000SEP08 Liver - 53%, Musculoskeletal System - 25% 129 LG:1080091.1-2000SEP08 Connective Tissue - 21%, Musculoskeletal System - 18%, Female Genitalia - 15% 130 LG:1082203.1-2000SEP08 Embryonic Structures - 23%, Endocrine System - 1 1%, Male Genitalia - 1 1% 131 LG 1084051.1:2000SEP08 Germ Cells - 33%, Pancreas - 11%, Male Genitalia - 11% 132 LG 1082393.1 :2000SEP08 Male Genitalia - 20%, Urinary Tract - 13%, Unclassified/Mixed - 13% 133 LG 1086183.1 :2000SEP08 Liver - 25%, Skin - 20%, Hemic and Immune System - 14% 134 LG 1090268.1.2000SEP08 Sense Organs - 40%, Unclassified/Mixed - 17% 135 LG 1400597.5:2000SEP08 Unclassified/Mixed - 53%, Connective Tissue - 47% 136 LG 1080307.2:2000SEP08 Digestive System - 100% 137 LG 1400603.2:2000SEP08 Germ Cells - 40%, Nervous System - 18%, Unclassified/Mixed - 12% ro 138 LG 1052984.1 :2000SEP08 Skin - 31%, Musculoskeletal System - 15%, Endocrine System - 10%, Nj t Pancreas - 10% 139 LG:1091259.1-2000SEP08 Connective Tissue - 66%, Respiratory System - 25% 140 LG:1082263.2:2000SEP08 Embryonic Structures - 32%, Endocrine System - 15%, Nervous System - 10% 141 LG 1048604.2:2000SEP08 Exocrine Glands - 50%, Embryonic Structures - 38% 142 LG 1085254.3:2000SEP08 Embryonic Structures - 61%, Respiratory System - 32% 143 LG 1400606.2:2000SEP08 Embryonic Structures - 34%, Unclassified/Mixed - 14%, Nervous System - 13%, Connective Tissue - 13% 144 LG:1090358.2:2000SEP08 Urinary Tract - 36%, Male Genitalia - 23%, Hemic and Immune System - 15%, Musculoskeletal System - 15% 145 LG:1079064.2:2000SEP08 Nervous System - 21%, Female Genitalia - 16%, Uver - 12% 146 LG:1076866.1.2000SEP08 Germ Cells - 28%, Embryonic Structures - 20%, Cardiovascular System - 12% 147 LG:969359.1:2000SEP08 Liver - 79%, Pancreas - 19% 148 LG:366783.1:2000SEP08 Sense Organs - 95% 149 LG:332176.3:2000SEP08 Pancreas - 28%, Connective Tissue - 22%, Urinary Tract - 22% 150 LG:994938.1:2000SEP08 Exocrine Glands - 50%, Respiratory System - 21%, Urinary Tract - 17% TABLE 6 SEQ ID NO: Template ID Tissue Distribution 151 LG:982800.1:2000SEP08 Urinary Tract - 22%, Skin - 21%, Germ Cells - 13% 152 LG:977850.7:2000SEP08 Exocrine Glands - 100% 153 LG:234748.2:2000SEP08 Sense Organs - 27%, Urinary Tract - 15%, Unclassified/Mixed - 1 1% 154 LG:306284.1:2000SEP08 Nervous System - 60%, Male Genitalia - 40% 155 U:333170.3:2000SEP08 Germ Cells - 82%, Unclassified/Mixed - 13% 156 U:336685.2:2000SEP08 Hemic and Immune System - 35%, Male Genitalia - 25%, Urinary Tract - 20% 157 U:279013.5:2000SEP08 Female Genitalia - 100% 158 LI:1037075.1 2000SEP08 Musculoskeletal System - 94% 159 LI:1073403.1 2000SEP08 Liver - 100% 160 LI:1075296.1 2000SEP08 Liver - 100% 161 LI:1085501.1 2000SEP08 Connective Tissue - 100% 162 LI:1086181.1 2000SEP08 u ' ver - 100% 163 LI:1164493.1 2000SEP08 Urinary Tract - 52%, Female Genitalia - 20%, Digestive System - 12%, Male Genitalia - 12% ) NJ 164 U:1175097.1:2000SEP08 Unclassified/Mixed - 57%, Digestive System - 21%, Nervous System - 21% 165 LI:1092948.1:2000SEP08 Embryonic Structures - 26%, Connective Tissue - 19%, Musculoskeletal System - 17% 166 LI:380378.2:2000SEP08 Nervous System - 100% 167 LI:1029674.1:2000SEP08 Digestive System - 42%, Nervous System - 36%, Unclassified/Mixed - 22% 169 11:1186208.1 :2000SEP08 Stomatognathic System - 51%, Sense Organs - 38% 170 LI:1170753.1 :2000SEP08 Endocrine System - 95% 171 U:l 180908.1 :2000SEP08 Skin - 21%, Embryonic Structures - 14%, Male Genitalia - 13% 172 U:1182900.2:2000SEP08 Digestive System - 47%, Pancreas - 34%, Respiratory System - 1 % 173 U:1169548.2:2000SEP08 Nervous System - 100% 174 LI:1039974.1:2000SEP08 Female Genitalia - 31%, Urinary Tract - 29%, Nervous System - 16% 175 LI:1175765.2:200OSEP08 Nervous System - 100% 176 LI:313948.1:2000SEP08 Unclassified/Mixed - 31%, Endocrine System - 23%, Cardiovascular System - 19% 177 U:335923.2:2000SEP08 Germ Cells - 74%, Male Genitalia - 26% 178 ^ U:345884.1:2000SEP08 Respiratory System - 75%, Hemic and Immune System - 25% 179 LI:417127.1:2000SEP08 Connective Tissue - 100% TABLE 6 SEQ ID NO: Template ID Tissue Distribution 180 LI 451710.1 :2000SEP08 Connective Tissue - 90%, Nervous System - 10% 181 LI 406882.2:2000SEP08 Sense Organs - 34%, Unclassified/Mixed - 15%, Nervous System - 15% 182 LI 728223.1:2000SEP08 Nervous System - 100% 183 U:289783.19:2000SEP08 Digestive System - 38%, Unclassified/Mixed - 15%, Respiratory System - 12% 184 LI 235255.8:2000SEP08 Exocrine Glands - 23%, Connective Tissue - 12%, Female Genitalia - 1 1% 185 LI 237693.5:2000SEP08 Urinary Tract - 32%, Hemic and Immune System - 25%, Endocrine System • 21% 186 LI:433670.3:2000SEP08 Nervous System - 50%, Male Genitalia - 25%, Digestive System - 25% 187 LI 202943.4:2000SEP08 Embryonic Structures - 42%, Liver - 19%, Unclassified/Mixed - 16% 188 LI 068682.1:2000SEP08 Unclassified/Mixed - 47%, Digestive System - 21%, Male Genitalia - 19% 189 LI 203301.3:2000SEP08 Germ Cells - 19%, Male Genitalia - 14%, Respiratory System - 12% 190 U:020726.3:2000SEP08 Sense Organs - 79% 191 LI 027209.1:2000SEP08 Musculoskeletal System - 53%, Female Genitalia - 27%, Exocrine Glands - ry Tract - 45%, Digestive System - 28%, Skin - 15% 193 U.021759.1 :2000SEP08 Hemic and Immune System - 40%, Nervous System - 22%, Uver - 1 1 % 1 4 Lh11659671.2000SEP08 Liver - 50%, Stomatognathic System - 50% 195 U:1166315.1:2000SEP08 Cardiovascular System - 33%, Urinary Tract - 27%, Female Genitalia - 20%, Hemic and Immune System - 20% 196 LI204626.1:2000SEP08 Digestive System - 58%, Nervous System - 15%, Exocrine Glands - 13% 197 LI.801140.1 :2000SEP08 Embryonic Structures - 50%, Cardiovascular System - 38% 198 LI:286639.1:2000SEP08 Germ Cells - 64% 199 U:288905.4:2000SEP08 Unclassified/Mixed - 76%, Nervous System - 24% 200 U:332161.1:2000SEP08 Cardiovascular System - 47%, Nervous System - 14%, Connective Tissue - 10% 201 LI: 184867.1 :2000SEP08 Unclassified/Mixed - 33%, Embryonic Structures - 24%, Male Genitalia - 16% 202 U:229932.4:2000SEP08 Musculoskeletal System - 40%, Cardiovascular System - 21% 203 LI:1189932.1:2000SEP08 Embryonic Structures - 37%, Germ Cells - 18%, Sense Organs - 13% 204 LI:1076689.1:2000SEP08 Uver - 99% 205 U:415181.2:2000SEP08 Nervous System - 100% TABLE 6 SEQ ID NO: Template ID Tissue Distribution 206 U:296358.1:2000SEP08 Hemic and Immune System - 83% 207 U:205186.3:2000SEP08 Cardiovascular System - 59%, Male Genitalia - 20%, Unclassified/Mixed - 16% 208 U:220537.2:2000SEP08 Stomatognathic System - 52%, Male Genitalia - 32% 209 U:248364.2:2000SEP08 Cardiovascular System - 30%, Female Genitalia - 23%, Sense Organs - 22% 210 U:2048338.1:2000SEP08 Connective Tissue - 90%, Nervous System - 10% 211 U:1185203.8:2000SEP08 Nervous System - 75%, Female Genitalia - 25% 212 U:021770.3:2000SEP08 Pancreas - 77% 213 LI:1185841.1:2000SEP08 Hemic and Immune System - 30%, Respiratory System - 26% 214 Ll:l 181710.1 :2000SEP08 Male Genitalia - 38%, Nervous System - 38%, Hemic and Immune System - 25% 215 U:2048959.1:2000SEP08 Musculoskeletal System - 73%, Endocrine System - 27% 216 LI:798494.1:2000SEP08 Germ Cells - 88% 217 U:2049223.1:2000SEP08 Male Genitalia - 60%, Hemic and Immune System - 40% 218 LI:1177833.1 :2000SEP08 Liver - 55%, Embryonic Structures - 10% 219 LI:2049267.1:2000SEP08 Cardiovascular System - 36%, Urinary Tract - 29%, Digestive System - 21 % 220 LI:1165939.1:2000SEP08 Sense Organs - 62%, Endocrine System - 20% 221 LI:1170958.1:2000SEP08 Exocrine Glands - 53%, Cardiovascular System - 26%, Male Genitalia - 16% 222 U:1089827.1 :2000SEP08 Endocrine System - 16%, Male Genitalia - 13%, Musculoskeletal System - 12% 223 LI:792112.1:2000SEP08 Liver - 83% 224 LI:282219.2:2000SEP08 Embryonic Structures - 55%, Exocrine Glands - 23%, Male Genitalia - 14% 225 LI:1088010.2:2000SEP08 Exocrine Glands - 31%, Musculoskeletal System - 23%, Respiratory System - 13% 226 LI:1165276.1:2000SEP08 Nervous System - 18%, Male Genitalia - 16%, Pancreas - 16% 227 U:1169524.2:2000SEP08 Endocrine System - 41%, Urinary Tract - 16%, Musculoskeletal System - 14%, Male Genitalia - 14% 228 U:l 180255.1 :2000SEP08 Female Genitalia - 66%, Liver - 1 1%, Embryonic Structures - 11% 229 U:1091903.1:2000SEP08 Germ Cells - 93% TABLE 6 SEQ ID NO: Template ID Tissue Distribution 230 LI:1169219.1:2000SEP08 Sense Organs - 34%, Skin - 22% 231 LI:2050313.1:2000SEP08 Skin - 15%, Respiratory System - 14%, Male Genitalia - 14% 232 U:209351.3:2000SEP08 Cardiovascular System - 41 % 233 U:119900.1:2000SEP08 Stomatognathic System - 77% 234 U:2052274.1:2000SEP08 Urinary Tract - 31%, Female Genitalia - 1 %, Liver - 12% 235 LI:1075502.1:2000SEP08 Liver - 100% 236 LI:813697.1;2000SEP08 Endocrine System - 36%, Unclassified/Mixed - 25%, Exocrine Glands - 15% 237 LI:814261.1:2000SEP08 Exocrine Glands - 50%, Respiratory System - 20%, Urinary Tract - 13% 238 LI:775334.1:2000SEP08 Cardiovascular System - 26%, Embryonic Structures - 23%, Unclassified/Mixed - 15% 239 LI:1180325.1 -2000SEP08 Skin - 38%, Pancreas - 23%, Female Genitalia - 23% 240 U:1183147.3:2000SEP08 Female Genitalia - 42%, Respiratory System - 17%, Nervous System - 13% 241 U:1175373.3:2000SEP08 Nervous System - 50%, Male Genitalia - 25%, Digestive System - 25% 242 U:813757.1:2000SEP08 Female Genitalia - 50%, Nervous System - 50% 243 LI:1182979.2:2000SEP08 Respiratory System - 67%, Pancreas - 19% 244 U:1177823.2:2000SEP08 Embryonic Structures - 48%, Cardiovascular System - 20%, Exocrine Glands - 20% 245 LI:1174279.1 -2000SEP08 Endocrine System - 36%, Nervous System - 1 %, Liver - 18% 246 U:l 178411.1 -2000SEP08 Nervous System - 21%, Liver - 18%, Exocrine Glands - 15% 247 LI:1182739.1 :2000SEP08 Unclassified/Mixed - 34%, Skin - 18%, Nervous System - 12% 248 LI:234937.4:2000SEP08 Endocrine System - 33%, Nervous System - 24%, Digestive System - 21 % 249 LI:1170660.1 :2000SEP08 Musculoskeletal System - 21%, Nervous System - 18%, Cardiovascular System - 13%, Male Genitalia - 13% 250 U:1144409.1:2000SEP08 Sense Organs - 53% 251 LI:246290.10:2000SEP08 Cardiovascular System - 29%, Female Genitalia - 29% 252 U:280034.1:2000SEP08 Female Genitalia - 100% TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 253 2 114 2 343 gl 1643582 2.00E-68 PR-domain containing protein 14 253 2 114 2 343 g10434076 2.00E-68 unnamed protein product 253 2 114 2 343 g7020503 4.00E-27 unnamed protein product 255 2 211 2 634 g7243243 2.00E-43 KIAA1431 protein 255 2 211 2 634 g4567178 2.00E-41 R31665_2 (AA 1- 673 ) 255 2 211 2 634 g3445181 2.00E-41 R31665.2 256 3 151 54 506 g10433955 5.00E-40 unnamed protein product 256 3 151 54 506 g7295442 4.00E-14 CGI 7334 gene product 256 3 151 54 506 g2073111 3.00E-11 Y box protein 2 257 2 138 17 430 g12407395 4.00E-54 tripartite motif protein TRIM 7 257 2 138 17 430 g12407397 2.00E-42 tripartite motif protein TRIM7 257 2 138 17 430 g12407379 8.00E-16 tripartite motif protein TRIM4 isoform beta 258 1 317 1 951 g9246977 1.00E-137 RNA-binding protein BRUNOL4 258 1 317 1 951 g12746394 1.00E-136 CUG-BP and ETR-3 like factor 4 258 1 317 1 951 g13278792 1.00E-106 Bruno (Drosophila) -like 4, RNA binding protein 260 2 114 14 355 g4589588 2.00E-34 KIAA0972 protein 260 2 114 14 355 g7576272 2.00E-30 bA393J16.1 (zinc finger protein 33a (KOX 31)) 260 2 114 14 355 g498152 2.00E-30 ha0946 protein is Kruppel-related. 261 2 127 140 520 g10434195 2.00E-64 unnamed protein product 261 2 127 140 520 g13529188 4.00E-42 Unknown (protein for MGC: 12466) 261 2 127 140 520 g6467206 3.00E-36 gonadotropin inducible transcription repressor-4 262 151 1 453 g14042293 4.00E-47 unnamed protein product 262 151 1 453 g12052983 1.00E-46 hypothetical protein 262 151 1 453 g487785 7.00E-46 zinc finger protein ZNF136 263 79 16 252 g349075 4.00E-16 calmodulin-binding protein 263 79 16 252 g13543326 4.00E-16 hypothetical protein MGC8407 263 79 16 252 g12804937 4.00E-16 Unknown (protein for MGC:3732) 264 183 112 660 g13325337 3.00E-83 Unknown (protein for MGC: 10520) 264 183 112 660 g8439407 3.00E-22 zinc finger protein 264 183 112 660 g7020166 3.00E-22 unnamed protein product 266 3 260 3 782 g12698001 1.00E-147 KIAA 1728 protein 266 3 260 3 782 g8052233 1.00E-94 putative ankyrin-repeat containing protein TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score ! Annotation 266 3 260 3 782 g7294632 2.00E-61 CG5679 gene product 267 2 196 2 589 g6249687 1.00E-108 R31 155J 267 2 196 2 589 g 10436360 1.00E-53 unnamed protein product 267 2 196 2 589 g 14042803 6.00E-50 unnamed protein product 268 1 1 13 130 468 g 14596085 7.00E-55 (AY042830) Putative 40S ribosomal protein SI 5A 268 1 1 13 130 468 g9757906 7.00E-55 40S ribosomal protein SI 5A 268 1 113 130 468 g8439890 7.00E-55 Strong similarity to 40S ribosomal protein SI 5A from Arabidopsis thaliana gb I L27461. EST gb | R30315 comes from this gene. 269 3 165 3 497 g 12052983 2.00E-73 hypothetical protein 269 3 165 3 497 g5262560 1.00E-47 hypothetical protein 269 3 165 3 497 g 10434856 1.00E-47 unnamed protein product 270 3 168 165 668 g 12052983 4.00E-70 hypothetical protein 270 3 168 165 668 g5262560 4.00E-35 hypothetical protein 270 3 168 165 668 g 10434856 5.00E-34 unnamed protein product 271 2 122 2 367 g 12044553 8.00E-48 bA261 P9.2 (putative novel protein similar to fly CG7340 and human putative amlnopeptidase ZK353.6 in chromosome 3 (EC 3.4.1 1.-)) 271 2 122 2 367 g 10432867 5.00E-47 unnamed protein product 271 2 122 2 367 g7299691 5.00E-42 BcDNA:LD41548 gene product (alt 1) 272 2 91 212 484 g872315 3.00E-35 40S ribosomal protein SI 2 272 2 91 212 484 g 12842004 3.00E-35 putative 272 2 91 212 484 gl2833134 3.00E-35 putative 273 3 225 3 677 g510552 1.OOE-100 ribosomal protein LI 3 273 3 225 3 677 g 12833027 1.00E-99 putative 273 3 225 3 677 g3869148 4.00E-98 robosomal protein LI 3 274 3 153 3 461 g825539 2.00E-84 MLC2 274 3 153 3 461 g 1675396 2.00E-84 myosin light chain 2 274 3 153 3 461 gl637 2.00E-84 myosin light chain 2 type 2 275 2 296 176 1063 g 12407387 1.OOE-l 47 tripartite motif protein TRIM5 isoform delta 275 2 296 176 1063 g 12407385 1.OOE-l 47 tripartite motif protein TRIM5 isoform gamma 275 2 296 176 1063 g 12407383 1.OOE-l 47 tripartite motif protein TRIM5 isoform beta 276 1 175 22 546 g 13752754 . 1.00E-26 zinc finger l l l l 276 1 175 22 546 g 14348588 5.00E-25 KRAB zinc finger protein TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 276 1 175 22 546 g12654015 4.00E-24 Similar to hypothetical protein FU 10891 277 3 76 141 368 g9714522 5.00E-13 bA162G10.3 (zinc finger protein) 277 3 76 141 368 g5730194 5.00E-13 KRAB protein domain 277 3 76 141 368 g4589588 8.00E-13 KIAA0972 protein 278 3 146 624 1061 g12697318 5.00E-14 PBX4 protein 278 3 146 624 1061 g7160798 9.00E-13 pbxy homeodomain protein 278 3 146 624 1061 g634053 9.00E-13 PBX2 279 3 391 3 1175 g10439850 1.OOE-l 16 unnamed protein product 279 3 391 3 1175 g9968290 1.OOE-l 12 zinc finger protein 304 279 3 391 3 1175 g14249844 1.OOE-l 11 Similar to hypothetical protein FU23233 280 3 80 156 395 g12052983 7.00E-15 hypothetical protein 280 3 80 156 395 g13277768 1.OOE-l 1 zinc finger protein 93 280 3 80 156 395 gl 184371 1.OOE-l 1 zinc finger protein; Method: conceptual translation supplied by author 281 2 162 74 559 gό467206 8.00E-37 gonadotropin inducible transcription repressor-4 281 2 162 74 559 g9187356 2.00E-36 hypothetical protein, similar to (AB021644)GONADOTROPIN INDUCIBLE TRANSCRIPTION REPRESSOR-4 281 2 162 74 559 g220637 2.00E-36 zinc finger protein 282 2 164 50 541 g13752754 1.00E-28 zinc finger l l l l 282 2 164 50 541 g14348588 5.00E-28 KRAB zinc finger protein 282 2 164 50 541 gl2654015 3.00E-27 Similar to hypothetical protein FU 10891 283 3 105 75 389 g12052732 2.00E-38 hypothetical protein 283 3 105 75 389 g3329372 9.00E-37 DNA-binding protein 283 3 105 75 389 g7959207 3.00E-34 KIAA1473 protein 284 123 289 657 g14042035 9.00E-64 unnamed protein product 284 123 289 657 g6224922 1.OOE-41 BTB/POZ domain zinc finger factor HOF-S 284 123 289 657 g6063139 1.OOE-41 BTB/POZ domain zinc finger factor HOF-L 285 174 199 720 g7022603 2.00E-20 unnamed protein product 285 174 199 720 g7022652 3.00E-10 unnamed protein product 285 174 199 720 g3283350 3.00E-08 calmodulin-binding protein SHA1 286 2 181 71 613 gl3591714 4.00E-97 (AF343664) immunoglobulin superfamily receptor translocation associated protein 2c TABLE 7 -IDNC >: Frame Length Start Stop Gl Number Probability Score Annotation 286 2 181 71 613 gl3591712 4.00E-97 (AF343663) immunoglobulin superfamily receptor translocation associated protein 2b 286 2 181 71 613 gl3591710 4.00E-97 (AF343662) immunoglobulin superfamily receptor translocation associated protein 2a 287 91 64 336 g10047183 8.00E-48 KIAA1559 protein 287 91 64 336 g5080758 8.00E-25 BC331 191J 287 91 64 336 g456269 1.00E-21 zinc finger protein 30 288 188 226 789 gl 1999277 4.00E-45 solute carrier 288 188 226 789 g12845461 8.00E-34 putative 288 188 226 789 g10434874 2.00E-33 unnamed protein product 289 2 290 2 871 gl4017771 1.OOE-l57 fibrillin3 289 2 290 2 871 g762831 1.OOE-l 13 fibrillin 2 289 2 290 2 871 g4959652 1.OOE-l 13 fibrillin-2 290 3 199 3 599 g375771 1.00E-83 dJ422F24.1 (PUTATIVE novel protein similar to C. elegans C02C2.5) 290 3 199 3 599 g12832288 5.00E-83 putative 290 3 199 3 599 g7294769 2.00E-38 CG6279 gene product 291 3 148 3 446 g13489168 5.00E-77 60S ribosomal protein LI 7 291 3 148 3 446 g13430182 3.00E-76 ribosomal protein LI 7 291 3 148 3 446 g14596111 2.00E-75 (AY042843) 60S ribosomal protein LI 7 292 1 92 37 312 g6002102 5.00E-39 Acyl-CoA binding protein (ACBP) 292 1 92 37 312 g1938236 3.00E-38 acyl-CoA-binding protein 292 1 92 37 312 g6002104 2.00E-37 Acyl-CoA binding protein (ACBP) 293 3 256 3 770 g50 1520 1.OOE-l27 ESTs AU058081 (E30812),AU058365(E50679), AU030138(E50679) correspond to a region of the predicted gene.; Similar to Spinacia oleracea mRNA for proteasome 37kD subunit.(X96974) 293 3 256 3 770 g8671496 1.OOE-l 27 alpha 3 subunit of 20S proteasome 293 3 256 3 770 g8096329 1.OOE-l 27 ESTs AU058081(E3082),AU075427(E30384) correspond to a region of the predicted gene. -Similar to Spinacia oleracea proteasome 27 kD subunit (P52427) 295 3 318 132 1085 gl 1602755 1.00E-37 zinc finger protein 295 3 318 132 1085 g12843135 6.00E-33 putative 295 3 318 132 1085 g13094151 3.00E-25 zinc finger protein hRitl alpha TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 296 194 304 885 g 12856559 1.00E-85 putative 296 194 304 885 g 12856631 3.00E-85 putative 296 194 304 885 g 12849896 3.00E-85 putative 297 469 1 1407 g9927838 0 unnamed protein product 297 469 1 1407 g 10045028 0 unnamed protein product 297 469 1 1407 g 10047295 1. OOE-l 69 KIAA1610 protein 298 3 81 3 245 g 13249093 5.00E-37 carbonic anhydrase XIII 298 3 81 3 245 gl 2845416 5.00E-37 putative 298 3 81 3 245 g65332 4.00E-22 carbonic anhydrase 299 452 1 1356 gl 1 177164 0 polydom protein 299 452 1 1356 g 12060830 1. OOE-l 42 serologically defined breast cancer antigen NY-BR-38 . 299 452 1 1356 g7292728 1.00E-52 fw gene product 300 362 97 1 182 g 14594722 0 (AY037298) elongation of very long chain fatty acids protein 300 362 97 1 182 g 12044051 0 ELOVL4 i 300 362 97 1 182 g 12044043 0 ELOVL4 - 301 2 354 2 1063 g 14272764 1. OOE-l 46 unnamed protein product 301 2 354 2 1063 g561853 5.00E-28 megalin 301 2 354 2 1063 g 1809240 7.00E-27 gp330 precursor 302 1 305 220 1 134 g 12483902 1.00E-83 zinc finger protein HIT-10 302 1 305 220 1 134 g6002480 4.00E-49 BWSCR2 associated zinc-finger protein BAZ2 302 1 305 220 1 134 g9963806 4.00E-47 zinc finger protein ZNF287 303 2 659 164 2140 g 14587851 0 (AB050785) Graf2 303 2 659 164 2140 gl3310137 0 PSGAP-m 303 2 659 164 2140 gl3310135 0 PSGAP-s 304 3 390 102 1271 g 13879442 1. OOE-l 70 Similar to RIKEN cDNA 2310035M22 gene 304 3 390 102 1271 g 12855490 1. OOE-l 65 putative 304 3 390 102 1271 g 12848905 1. OOE-l 02 putative 305 2 294 2 883 g 13898617 1. OOE-l 42 serine/threonine protein kinase SSTK 305 2 294 2 883 g 13540326 1. OOE-l 42 serine/threonine kinase FKSG82 305 2 294 2 883 g 13898619 1. OOE-l 40 serine/threonine protein kinase SSTK 306 1 269 1 807 g 14250138 1. OOE-l 39 Similar to RIKEN cDNA 5730421 El 8 gene 306 1 269 1 807 g 12856916 1. OOE-l 20 putative TABLE 7 - ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 306 1 269 1 807 g12840367 1.OOE-l20 putative 307 3 270 393 1202 g10434082 1.OOE-l03 unnamed protein product 307 3 270 393 1202 g12052816 1.OOE-l02 hypothetical protein 307 3 270 393 1202 g297157 1.00E-74 rabl 7 308 3 358 150 1223 g12861800 1.OOE-l 70 putative 308 3 358 150 1223 g3878713 5.00E-73 (Z46935) weak similarity with quinone oxidoreductase, contains similarity to Pfam domain: PF00107 (Zinc-binding dehydrogenases), Score=-80.6, E- value=6.2e-06, N=l -cDNA EST ykl64b4.5 comes from this gene-cDNA EST ykl64b4.3 comes from this gene-cDNA EST yk264f3.5 comes from this 308 3 358 150 1223 g2633069 2.00E-52 similar to quinone oxidoreductase 309 2 232 2 697 g12834244 1.00E-71 putative 309 2 232 2 697 g12833174 1.00E-71 putative 309 2 232 2 697 g13905260 1.00E-36 RIKEN cDNA 1300006C06 gene 310 3 184 3 554 g2335037 9.00E-67 Tim 17 310 3 184 3 554 g4378524 2.00E-65 mitochondrial inner membrane translocase component Tim 17a 310 3 184 3 554 g12833600 2.00E-65 putative 311 1 206 46 663 g12314268 4.00E-82 dJ14Nl .2 (novel S-100/ICaBP type calcium binding domain protein, similar to trichohyalin) 311 1 206 46 663 g553621 3.00E-14 profilaggrin 311 1 206 46 663 g12314267 3.00E-14 dJ 14N 1.1.1 (profilaggrin 5' end) 312 2 301 59 961 gl2314195 1.OOE-l 71 bA255Al 1.3 (novel protein similar to KIAA1074) 312 2 301 59 961 gl2314164 1.OOE-l34 bA526D8.2 (novel protein similar to KIAA1074) 312 2 301 59 961 g12053099 4.00E-95 hypothetical protein 313 156 70 537 g6692607 2.00E-65 MGA protein 313 156 70 537 g5931585 1.00E-44 T-box family member; T-box domain 313 156 70 537 g4049463 4.00E-16 transcription factor TBX6 314 279 340 1176 g12854977 1.OOE-l 23 putative 314 279 340 1176 g7267246 1.OOE-41 putative adenosine deaminase 314 279 340 1176 g7299138 2.00E-39 CGI 1994 gene product 315 329 181 1167 g4582324 0 dJ708F5.1 (PUTATIVE novel Collagen alpha 1 LIKE protein) 315 329 181 1167 g12052774 0 hypothetical protein 315 329 181 1167 g2326442 1.00E-38 collagen type XII alpha 1 chain TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 316 3 757 3 2273 g8896164 0 kinesin-like protein GAKIN 316 3 757 3 2273 g 10697238 0 KIF13A 316 3 757 3 2273 g 12054032 0 KINESIN-13A2 317 329 1 987 g 14595658 8.00E-97 (AF387815) UM protein prickle 317 329 1 987 g9229890 3.00E-84 prickle 2 317 329 1 987 g9229888 3.00E-83 prickle 1 318 494 1 1482 g 1763096 0 glutamate pyruvate transaminase 318 494 1 1482 g467528 0 alanine aminotransferase 318 494 1 1482 g 1507680 0 alanine aminotransferase 319 156 400 867 g5912051 2.00E-30 hypothetical protein 319 156 400 867 g 14278937 2.00E-30 calmin 319 156 400 867 g 10437695 2.00E-30 unnamed protein product 320 128 1 18 501 g7294107 4.00E-44 CG4638 gene product 320 128 1 18 501 g3169065 3.00E-40 elongation factor 2-like protein 320 128 1 18 501 gl302132 4.00E-38 ORF YN LI 63c 321 197 151 741 g 13185203 2.00E-21 unnamed protein product 321 197 151 741 g2463632 3.00E-14 monocarboxylate transporter homologue MCT6 321 197 151 741 gόl 03363 3.00E-13 monocarboxylate transporter MCT3 322 560 1 1680 g4240293 1. OOE-l 41 KIAA0902 protein 322 560 1 1680 g4151807 1. OOE-l 41 membrane-associated guanylate kinase-interacting protein 2 Maguin-2 322 560 1 1680 g4151805 1. OOE-l 41 membrane-associated guanylate kinase-interacting protein 1 Maguin-1 323 2 163 2 490 g 10172680 3.00E-06 stage V sporulation protein C (peptidyl-tRNA hydrolase) 323 2 163 2 490 gl 001232 4.00E-06 (D64003) peptidyl-tRNA hydrolase 323 2 163 2 490 g2983032 1.00E-05 peptidyl-tRNA hydrolase 324 2 197 2 592 g9295345 2.00E-67 HSKM-B 324 2 197 2 592 g 12834773 5.00E-19 putative 324 2 197 2 592 g5870834 3.00E-17 skm-BOP2 325 3 520 3 1562 g8655678 1. OOE-l 39 hypothetical protein 325 3 520 3 1562 g 12382779 1.00E-59 zinc transporter 1 325 3 520 3 1562 g577843 2.00E-59 ZnT-1 326 1 772 640 2955 g 13358642 0 hypothetical protein 326 ' 1 772 640 2955 g 10435064 0 unnamed protein product TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 326 1 772 640 2955 g 10434826 , 0 unnamed protein product 327 3 702 153 2258 g726402ό 0 dJ876B10.2 (novel protein (ortholog of rat EX084)) 327 3 702 153 2258 g2827164 0 exo84 327 3 702 153 2258 g7301432 2.00E-38 CG6095 gene product 328 3 255 609 1373 g 13383265 1. OOE-l 06 actin related protein 328 3 255 609 1373 g 13938319 1. OOE-l 05 Unknown (protein for MGC: 15664) 328 3 255 609 1373 g 12840619 9.00E-72 putative 330 2 178 203 736 g 10435210 2.00E-76 unnamed protein product 330 2 178 203 736 g 14598968 3.00E-58 (AX179297) 21615 ADH 330 2 178 203 736 g8895083 3.00E-58 oxidoreductase UCPA 331 217 1624 2274 g8655648 1. OOE-l 08 hypothetical protein 331 217 1624 2274 g 12803319 1. OOE-l 08 Unknown (protein for MGC3090) 331 217 1624 2274 g 10047337 1. OOE-l 08 KIAA 1630 protein 332 191 823 1395 g9651711 4.00E-72 arsenite inducible RNA associated protein 332 191 823 1395 g 12835478 3.00E-53 putative 332 191 823 1395 g7295806 6.00E-45 CGI 2795 gene product 333 2 252 1223 1978 g 12856598 6.00E-93 putative 333 2 252 1223 1978 g 14042913 2.00E-19 unnamed protein product 333 2 252 1223 1978 gl 4424618 9.00E-19 hypothetical protein MGC2628 334 2 502 305 1810 g 12845866 1. OOE-l 31 putative 334 2 502 305 1810 g 13477235 4.00E-80 Similar to RIKEN cDNA 0610037N03 gene 334 2 502 305 1810 g 12833017 6.00E-22 putative 335 2 369 2 1108 g 12856270 1. OOE-l 65 putative 335 2 369 2 1108 g6682873 1. OOE-l 19 reduced expression in cancer 335 2 369 2 1 108 g7230612 1. OOE-l 16 small rec 337 2 332 2 997 g8886025 1. OOE-l 66 collapsin response mediator protein-5 337 2 332 2 997 g8671 168 1 , OOE-l 66 hypothetical protein 337 2 332 2 997 g 13259169 1. OOE-l 66 phosphoprotein ULIP6 338 1 215 73 717 g 12652727 1. OOE-l 25 Unknown (protein for IMAGE:3352566) 338 1 215 73 717 g488555 2.00E-67 zinc finger protein ZNF135 338 1 215 73 717 g8050899 6.00E-65 ZNF180 339 3 364 3 1094 g9758769 1.00E-64 11-beta-hydroxysteroid dehydrogenase-like TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 339 3 364 3 1094 g8777393 1.00E-64 1 1 -beta-hydroxysteroid dehydrogenase-like 339 3 364 3 1094 g8777400 1.00E-54 contains similarity to oxidoreductase~gene_id:MFB16.17 340 3 229 21 707 g 12052959 1. OOE-l 30 hypothetical protein 340 3 229 21 707 g 14336767 1. OOE-l 28 similar to homoprotocatechuate catabolism bifunctional isomerase/decarboxylase 340 3 229 21 707 g7670464 1. OOE-l 15 unnamed protein product 341 164 235 726 g2286123 8.00E-47 testis specific DNAj-homolog 341 164 235 726 g 12838392 8.00E-47 putative 341 164 235 726 g 12838396 4.00E-46 putative 342 131 199 591 g 12804323 5.00E-60 Unknown (protein for MGC:4054) 342 131 199 591 g3264773 5.00E-32 zinc-finger protein-37; ZFP-37 342 131 199 591 g 10440398 5.00E-32 FU00032 protein 343 2 406 701 1918 g 12697482 1. OOE-l 21 dJ583Pl 5.7.2 (novel zinc finger protein similar to rat RIN ZF) 343 2 406 701 1918 g 12855580 1.00E-81 putative 343 2 406 701 1918 g 12847599 7.00E-78 putative 344 3 219 3 659 g60 1722 3.00E-51 putative ribosomal protein LI 3 344 3 219 3 659 g6650751 2.00E-49 ribosomal protein 1 344 3 219 3 659 g2984157 4.00E-28 ribosomal protein LI 3 345 2 134 95 496 g 14042747 4.00E-63 unnamed protein product 345 2 134 95 496 g 10440516 4.00E-63 FU00106 protein 345 2 134 95 496 g 10445215 7.00E-62 PDZ-LIM protein mystique 346 3 174 3 524 gl 1527997 1. OOE-l 12 NOTCH2 protein 346 3 174 3 524 gl 1275978 1. OOE-l 12 NOTCH 2 346 3 174 3 524 g287990 1. OOE-l 12 Motch B 347 1 306 202 1 1 19 g 14024759 4.00E-32 aldehyde dehydrogenase 347 1 306 202 1 1 19 gl 3162101 3.00E-28 putative aldehyde dehydrogenase 347 1 306 202 11 19 g 14025513 1.00E-23 succinate-semialdehyde dehydrogenase 348 3 283 819 1667 g 10438978 1. OOE-l 56 unnamed protein product 348 3 283 819 1667 g 13358630 1. OOE-l 55 hypothetical protein 348 3 283 819 1667 g9280094 1.00E-36 unnamed protein product 349 3 188 123 686 g4126809 5.00E-88 glyoxalase 1 349 3 188 123 686 g 1808684 3.00E-84 hypothetical protein TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 349 3 188 123 686 g2213425 8.00E-81 hypothetical protein 350 176 1 528 g57469 2.00E-98 vasopressin 350 176 1 528 g4469315 2.00E-98 vasopressin precursor 350 176 1 528 g207674 3.00E-96 vasopressin/neurophysin precursor 351 52 253 408 g3790135 3.00E-18 dJ191N21.3 (proteasome subunit HC5) 351 52 253 408 g220026 3.00E-18 proteasome subunit C5 351 52 253 408 g 1698584 3.00E-18 proteasome beta-subunit C5 352 3 190 3 572 g205662 5.00E-86 nucleoside diphosphate kinase 352 3 190 3 572 g206580 4.00E-85 RBL-NDP kinase 18kDa subunit (pi 8) 352 3 190 3 572 g53354 5.00E-85 nucleoside diphosphate kinase B 353 3 135 546 950 g9368839 1.00E-37 hypothetical protein 353 3 135 546 950 g57690 9.00E-29 ribosomal protein L23a 353 3 135 546 950 g404015 9.00E-29 ribosomal protein L23a 354 1 517 1 1551 gl3161 184 0 cytochrome P4502S1 354 1 517 1 1551 g 14042396 0 unnamed protein product 354 1 517 1 1551 g 12836063 0 putative 355 2 135 203 607 g7677318 5.00E-55 aldehyde reductase 355 2 135 203 607 g 12848322 5.00E-55 putative 355 2 135 203 607 g 12848318 5.00E-55 putative 356 3 77 42 272 g3851089 1.00E-24 guanine nucleotide binding protein gamma 5 356 3 77 42 272 g3329380 1.00E-24 G protein gamma 5 subunit 356 3 77 42 272 g204241 1.00E-24 G protein gamma-5 subunit 357 3 1 10 96 425 g7340072 4.00E-15 40S ribosomal protein S15A 357 3 no 96 425 g495273 4.00E-15 ribosomal protein SI 5a 357 3 no 96 425 g 12859337 4.00E-15 putative 358 485 1455 g 10436300 0 unnamed protein product 358 485 1455 g 10433852 0 unnamed protein product 358 485 1455 g9280029 0 unnamed protein product 360 143 429 g63466 2.00E-56 histone H2A 360 143 429 gό094631 2.00E-56 histone H2A.F 360 143 429 g3420799 2.00E-56 histone H2A.F/Z variant 361 3 81 159 401 g 10437078 4.00E-34 unnamed protein product TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 361 3 81 159 401 g 12859774 6.00E-33 putative 361 3 81 159 401 g 12857408 6.00E-33 putative 362 3 543 834 2462 g 12849316 4.00E-87 putative 362 3 543 834 2462 g6164628 3.00E-86 SH3 and PX domain-containing protein SH3PX1 362 3 543 834 2462 g5410249 3.00E-86 SDP1 protein 363 1 185 1 555 g 12836716 1. OOE-l 03 putative 363 1 185 1 555 g 12834312 1. OOE-l 03 putative 363 1 185 1 555 g 12832330 1. OOE-l 03 putative 364 3 156 177 644 g 14456629 1.00E-31 dJ54B20.2 (novel KRAB box containing C2H2 type zinc finger protein) 364 3 156 177 644 g4589588 9.00E-27 KIAA0972 protein 364 3 156 177 644 g3970712 3.00E-23 zinc finger protein 10 365 183 235 783 g 12248382 7.00E-31 SEMB 365 183 235 783 g854326 7.00E-29 semaphorin B 365 183 235 783 gl 1 10599 1. OOE-l 4 semaphorin homolog=M-Sema F (mice, neonatal brain, Peptide, 834 aa) t 0o0 366 416 1 1248 g 13543419 1. OOE-l 61 Similar to zinc finger protein 304 - J 366 416 1 1248 g7020745 5.00E-53 unnamed protein product 366 416 1 1248 g 12652759 5.00E-53 hypothetical protein FU20557 367 2 258 455 1228 gl l74187 2.00E-94 purine nucleotide binding protein 367 2 258 455 1228 g 193444 8.00E-88 guanylate binding protein 367 2 258 455 1228 g829177 1.00E-68 guanylate binding protein isoform II 368 3 68 270 473 g 14586963 7.00E-10 (AF362574) M75 368 3 68 270 473 g571 15 7.00E-10 ribosomal protein L31 (AA 1-125) 368 3 68 270 473 g36130 7.00E-10 ribosomal protein L31 (AA 1-125) 371 1 122 568 933 g 10435150 2.00E-39 unnamed protein product 371 1 122 568 933 g49821 5 2.00E-16 lepA protein 371 1 122 568 933 g2984041 6.00E-16 G-protein LepA 372 3 1 1 1 3 335 g 13752754 3.00E-15 zinc finger l l l l 372 3 1 1 1 3 335 g7023216 2.00E-14 unnamed protein product 372 3 11 1 3 335 g 14348588 2.00E-14 KRAB zinc finger protein 373 3 1281 36 3878 g 157409 2.00E-95 fat protein 373 3 1281 36 3878 g7295732 3.00E-94 ft gene product 373 3 1281 36 3878 g 10727403 2.00E-93 ds gene product TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 374 3 164 3 494 g9759463 2.00E-60 40S ribosomal protein SI 9 374 3 164 3 494 g6513924 4.00E-60 putative 40S ribosomal protein SI 9 374 3 164 3 494 g13878029 4.00E-60 putative 40S ribosomal protein SI 9 375 3 365 750 1844 g55628 0 reading frame (preproalbumin) 375 3 365 750 1844 g3647327 0 serum albumin 375 3 365 750 1844 g12845183 0 putative 376 1 96 184 471 g12853416 5.00E-25 putative 376 1 96 184 471 g13529497 8.00E-23 Unknown (protein for MGC6652) 376 1 96 184 471 g4589588 5.00E-22 KIAA0972 protein 377 2 106 125 442 g14042293 3.00E-37 unnamed protein product 377 2 106 125 442 g12052983 3.00E-37 hypothetical protein 377 2 106 125 442 g14043841 7.00E-34 Unknown (protein for MGC: 14429) 378 2 119 2 358 g57710 2.00E-31 ribosomal phosphoprotein PI (AA 1-1 14) 378 2 119 2 358 g190234 2.00E-31 acidic ribosomal phosphoprotein (PI) 378 2 119 2 358 g14043204 2.00E-31 ribosomal protein, large, PI 380 2 282 2 847 g10440398 8.00E-93 FU00032 protein 380 2 282 2 847 g10047297 8.00E-93 KIAA161 1 protein 380 2 282 2 847 g10436789 6.00E-92 unnamed protein product 381 2 47 287 427 g7290056 2.00E-10 EG:1 18B3.2 gene product (alt 2) 381 2 47 287 427 g5901822 2.00E-10 EG:1 18B3.2 TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 381 2 47 287 427 g3645991 2.00E-10 /prediction=(method:""genefinder"", version :""084"", score:""128.32"")~/prediction=(method:""genscan"", version:""l .0"")~/match=(desc:""KIAA0376 PROTEIN (FRAGMENT)"", species:""HOMO SAPIENS (HUMAN)"", ranges: (query: 15779..16030, target-SPTREMBL: ::O15081 :314..231, score:""229.00""), (query: 14786..15736, target.SPTREMBL: ::O15081 :650..334, score:""319.00""), (query: 13868..13960, target:SPTREMBL: ::O15081 :884..854, score:"" 156.00"")), rnethod:""blastx"", version:""l ,4.9"")~/match=(desc:""SPECTRIN BETA CHAIN, ERYTHROCYTE"", species:""HOMO SAPIENS (HUMAN)"", ranges:(query: 13748..13954, target:SWISS-PROT::Pl 1277:242..174, score:""201.00"")), method:""blastx"", version:""l .4.9"")~/match=( esc:""GH04661.5prime GH Drosophila melanogaster head pOT2 Drosophila melanogaster cDNA clone GH04661 δprime, mRNA sequence"", specles:""Drosophila melanogaster (fruit fly)"", ranges:(query:22139..22499, target:EMBL::AI064293:3όl ..1, score:""! 796.00"")), method:""blastn"", version:""l ,4.9"")~/match=(desc:""GH05563.5prime GH Drosophila melanogaster head pOT2 Drosophila melanogaster cDNA clone GH05563 383 1 280 16 855 g14456629 9.00E-90 dJ54B20.2 (novel KRAB box containing C2H2 type zinc finger protein) 383 1 280 16 855 g3378094 3.00E-72 KRAB domain zinc finger protein 383 1 280 16 855 g1020145 1.00E-71 DNA binding protein 384 3 264 3 794 g6807587 1.OOE-l24 hypothetical protein 384 3 264 3 794 g5931821 1.OOE-l24 dJ228Hl 3.3 (zinc finger protein) 384 3 264 3 794 g488555 1.00E-96 zinc finger protein ZNF135 385 3 561 135 1817 g10954044 0 KRAB zinc finger protein ZFQR 385 3 561 135 1817 g10442700 0 zinc-finger protein ZBRK1 385 3 561 135 1817 g10435411 0 unnamed protein product 386 2 288 206 1069 g10439850 4.00E-70 unnamed protein product 386 2 288 206 1069 g4894364 6.00E-64 zinc finger protein 3 386 2 288 206 1069 gl2655165 6.00E-64 zinc finger protein 256 387 3 476 171 1598 g14042538 0 unnamed protein product 387 3 476 171 1598 g10438630 0 unnamed protein product 387 3 476 171 1598 g1309691 0 Similar to zinc finger protein 135 (clone pHZ-17) TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 389 3 60 78 257 g5262560 5.00E-07 hypothetical protein 389 3 60 78 257 g 10434856 5.00E-07 unnamed protein product 389 3 60 78 257 g 13623354 6.00E-07 Similar to zinc finger protein 136 (clone pHZ-20) 390 2 355 254 1318 g 10047183 1.00E-94 KIAA1559 protein 390 2 355 254 1318 g 13676461 6.00E-81 hypothetical protein 390 2 355 254 1318 g4589566 1.00E-80 KIAA0961 protein 391 1 101 1 12 414 g 13937999 3.00E-48 Similar to DNA-binding protein 391 1 101 112 414 g3329372 1.00E-34 DNA-binding protein 391 1 101 112 414 g 12052732 3.00E-34 hypothetical protein 392 3 326 3 980 gl4017921 0 KIAA1852 protein 392 3 326 3 980 g8050899 1. OOE-l 33 ZNF180 392 3 326 3 980 g6409345 1. OOE-l 33 zinc finger protein ZNF180 393 3 263 792 1580 g5441615 1.00E-96 zinc finger protein 393 3 263 792 1580 g498721 1.00E-94 zinc finger protein 393 3 263 792 1580 g8099348 2.00E-93 zinc finger protein 394 3 121 372 734 g 10439850 3.00E-18 unnamed protein product 394 3 121 372 734 g 14249844 7.00E-18 Similar to hypothetical protein FU23233 394 3 121 372 734 g2689441 4.00E-13 F18547J 395 2 298 2 895 g 10437560 0 unnamed protein product 395 2 298 2 895 g 10047305 0 KIAA1615 protein 395 2 298 2 895 g498721 4.00E-86 zinc finger protein 396 287 220 1080 g 14042550 3.00E-94 unnamed protein product 396 287 220 1080 g 13937909 3.00E-94 Similar to KIAA0961 protein 396 287 220 1080 g 10047183 5.00E-78 KIAA1559 protein 397 281 277 1 119 g3540177 1. OOE-l 23 F23269_2 397 281 277 1 119 g5080758 1. OOE-l 20 BC331 191J 397 281 277 1 119 g 12855931 5.00E-73 putative 398 263 1 789 g 10434650 4.00E-88 unnamed protein product 398 263 1 789 g 13623217 2.00E-40 Similar to hypothetical protein FU 12895 398 263 1 789 g7020855 6.00E-27 unnamed protein product 399 2 646 200 2137 g 14042373 0 unnamed protein product 399 2 646 200 2137 g498152 0 ha094ό protein is Kruppel-related. TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 399 2 646 200 2137 g7243633 0 RB-associated KRAB repressor 400 2 199 140 736 g204123 5.00E-89 ferritin light chain 400 2 199 140 736 g204133 6.00E-89 ferritin light chain 400 2 199 140 736 g193275 ό.OOE-89 ferritin light chain 401 1 210 25 654 g9651704 4.00E-79 carboxypeptidase B precursor 401 1 210 25 654 g6013463 8.00E-61 carboxypeptidase homolog 401 1 210 25 654 g203295 8.00E-61 carboxypeptidase B 402 2 390 2 1171 g!3365901 0 hypothetical protein 402 2 390 2 1171 g2104689 1.OOE-l26 alpha glucosidase II, alpha subunit 402 2 390 2 1171 g1890664 1.OOE-l26 glucosidase II 403 3 43 348 476 g12052884 3.00E-06 hypothetical protein 403 3 43 348 476 g7023332 4.00E-06 unnamed protein product 403 3 43 348 476 g183002 6.00E-05 guanylate binding protein isoform I 404 406 1218 gl2053281 0 hypothetical protein 404 406 1218 gl2836135 1.OOE-l67 putative 404 406 1218 g3043598 2.00E-64 KIAA0537 protein 405 90 270 g7981261 4.00E-33 dJ50O24.4 (novel protein with DHHC zinc finger domain) 405 90 270 g14035816 4.00E-33 unnamed protein product 405 90 270 g12224992 4.00E-33 hypothetical protein 407 2 192 44 619 g7297667 1.00E-30 CG5022 gene product 407 2 192 44 619 g2224617 4.00E-30 KIAA0338 407 2 192 44 619 g13277297 4.00E-30 bA234K24.1.2 (Erythrocyte membrane protein band 4.1 -like 1 protein (KIAA0338) isoform 2) 408 1 183 28 576 g12314083 9.00E-94 dJ1007G16.5 (novel high-mobility group (nonhistone chromosomal) protein 2 (HMG2) like protein) 408 1 183 28 576 g12838247 4.00E-67 putative 408 1 183 28 576 gl304193 9.00E-35 HMG2 409 3 163 3 491 g12697320 8.00E-51 Pbx4 protein 409 3 163 3 491 g7160800 3.00E-50 Pbx4/Lazarus homeodomain protein 409 3 163 3 491 g5679283 3.00E-50 Pbx4 homeodomain protein 410 3 186 198 755 g12840673 2.00E-48 putative 410 3 186 198 755 g607003 4.00E-18 beta transducin-like protein TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 410 3 186 198 755 g3878300 1. OOE-l 4 predicted using Genefinder-Similarity to C.elegans Guanine nucleotide binding protein (WP:C14B1.4), contains similarity to Pfam domain: PF00400 (WD domain, G-beta repeat), Score= 196.1, E-value=1.8e-55, N=7~cDNA EST yk567gl2.3 comes from this gene-cDNA EST yk567gl2.5 comes from this gene 411 1 134 286 687 g11342541 2.00E-67 putative white family ATP-binding cassette transporter 411 1 134 286 687 g9665220 3.00E-50 ATP-binding cassette transporter, sub-family G member 1 411 1 134 286 687 g7768742 3.00E-50 white protein homolog (ATP-binding cassette transporter 8) 412 2 97 35 325 g57175 1.00E-37 S- 100 protein 412 2 97 35 325 g206825 1.00E-37 SI 00 protein 412 2 97 35 325 g404769 2.00E-37 SI 00 beta protein 413 1 181 1 543 g13543071 9.00E-64 RIKEN cDNA 1500031 N16 gene 413 1 181 1 543 g12837801 9.00E-64 putative 413 1 181 1 543 g12832973 5.00E-60 putative 414 3 258 3 776 g12856949 4.00E-98 putative 414 3 258 3 776 g12653785 3.00E-97 Unknown (protein for IMAGE:3349601) 414 3 258 3 776 g12845723 4.00E-94 putative 415 2 169 2 508 g7259240 1.00E-79 unnamed protein product 415 2 169 2 508 g12845457 1.00E-79 putative 415 2 169 2 508 g12834293 1.00E-79 putative 416 1 177 310 840 g9502403 5.00E-06 Hypothetical zinc finger-like protein 417 1 81 451 693 g14042550 ό.OOE-27 unnamed protein product 417 1 81 451 693 g13937909 6.00E-27 Similar to KIAA0961 protein 417 1 81 451 693 g487787 3.00E-23 zinc finger protein ZNF140 418 2 94 329 610 g13752754 7.00E-18 zinc finger l l l l 418 2 94 329 610 g14348588 1.OOE-l6 KRAB zinc finger protein 418 2 94 329 610 g12654015 1.OOE-l6 Similar to hypothetical protein FU 108 1 419 3 165 3 497 g12856090 2.00E-51 putative 419 3 165 3 497 g12854104 2.00E-51 putative 419 3 165 3 497 g4678718 4.00E-43 dJ20l3,l (brain mitochondrial carrier protein- 1 (BMCP1)) 420 3 352 111 1166 g13444976 4.00E-36 unnamed protein product 420 3 352 111 1166 g12309630 4.00E-36 bA438B23.1 (neuronal leucine-rich repeat protein) TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 420 3 352 111 1166 g9651089 8.00E-34 hypothetical protein 421 2 113 2 340 gl4164613 3.00E-27 sialic acid binding immunoglobulin-like lectin 10 421 2 113 2 340 g13991167 ό.OOE-16 sialic acid-binding immunoglobulin-like lectin-like long splice variant 421 2 113 2 340 g13991166 6.00E-16 sialic acid-binding immunoglobulin-like lectin-like short splice variant 422 2 100 101 400 g12052732 1.OOE-38 hypothetical protein 422 2 100 101 400 g3329372 8.00E-37 DNA-binding protein 422 2 100 101 400 g7959207 2.00E-34 KIAA1473 protein 423 1 117 1 351 g7959207 8.00E-39 KIAA1473 protein 423 1 117 1 351 g3342002 2.00E-36 hematopoietic cell derived zinc finger protein 423 1 117 1 351 g186774 5.00E-35 zinc finger protein 424 2 250 2 751 g14042850 2.00E-50 unnamed protein product 424 2 250 2 751 g12052983 8.00E-37 hypothetical protein 424 2 250 2 751 g14042293 1.00E-36 unnamed protein product 425 1 199 1 597 g10437560 1.OOE-l05 unnamed protein product 425 1 199 1 597 g10047305 1.OOE-l05 KIAA1615 protein 425 1 199 1 597 g13436440 2.00E-77 Unknown (protein for MGC:4400) 426 3 166 3 500 g14017833 3.00E-86 KIAA1808 protein 426 3 166 3 500 g4240175 ό.OOE-24 KIAA0843 protein 426 3 166 3 500 g505094 5.00E-21 similar to an actin bundling protein, dematn. 427 1 157 1168 1638 g14042421 4.00E-11 unnamed protein product 427 1 157 1168 1638 g14017937 4.00E-11 KIAA1860 protein 427 1 157 1168 1638 g13366084 4.00E-11 MAP/microtubule affinity-regulating kinase like 1 429 3 200 3 602 g9651099 1.OOE-l 18 hypothetical protein 429 3 200 3 602 g881564 1.00E-55 ZNF157 429 3 200 3 602 g453466 5.00E-55 zinc finger protein 430 2 173 2 520 g11990770 2.00E-67 bA534G20.1.1 (novel protein similar to Lysozyme C-l (1,4-beta-N- acylmuramidase C, EC 3.2.1.17) (isoform 1 )) 430 2 173 2 520 gl 1990771 1.00E-56 bA534G20.1.2 (novel protein similar to Lysozyme C-l (1 ,4-beta-N- acylmuramidase C, EC 3.2.1.17) (isoform 2)) 430 2 173 2 520 g12839824 3.00E-49 putative 431 1 181 76 618 gl3591714 4.00E-97 (AF343664) immunoglobulin superfamily receptor translocation associated protein 2c TABLE 7 - ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 431 1 181 76 618 gl3591712 4.00E-97 (AF343663) immunoglobulin superfamily receptor translocation associated protein 2b 431 1 181 76 618 gl3591710 4.00E-97 (AF343662) immunoglobulin superfamily receptor translocation associated protein 2a 433 1 157 22 492 g7268562 7.00E-54 ribosomal protein L32-like protein 433 1 157 22 492 g5816996 7.00E-54 ribosomal protein L32-like protein 433 1 157 22 492 g13899057 2.00E-53 ribosomal protein L32 434 1 182 157 702 gl2855141 5.00E-89 putative 434 1 182 157 702 g12852338 5.00E-89 putative 434 1 182 157 702 g12849745 5.00E-89 putative 435 2 134 2 403 g2624328 2.00E-44 OsGRP2 435 2 134 2 403 g2366750 2.00E-34 RNA binding protein 435 2 134 2 403 g7268089 8.00E-34 glycine-rich RNA-binding protein AtGRP2-like 436 2 148 731 1174 g13397122 1.00E-58 unnamed protein product 436 2 148 731 1174 g12654715 1.00E-58 Similar to glucose regulated protein, 58 kDa 436 2 148 731 1174 g10728195 3.00E-15 CGI 837 gene product 437 2 296 2 889 g12597312 1.OOE-l49 tRNA-guanine transglycosylase 437 2 296 2 889 g12597314 1.OOE-l 37 tRNA-guanine transglycosylase 437 2 296 2 889 g7415812 1.OOE-l 35 tRNA-guanine transglycosylase 438 3 169 9 515 g12406772 4.00E-52 unnamed protein product 438 3 169 9 515 g12406688 4.00E-52 unnamed protein product 438 3 169 9 515 g7299372 4.00E-29 CG6567 gene product 439 2 170 200 709 gl4133251 3.00E-93 KIAA1479 protein 439 2 170 200 709 g2623162 7.00E-39 semaphorin Via 439 2 170 200 709 g11093909 7.00E-39 axon guidance signal SEMA6A1 440 2 841 2 2524 glll77164 0 polydom protein 440 2 841 2 2524 g12060830 1.OOE-l55 serologically defined breast cancer antigen NY-BR-38 440 2 841 2 2524 gl4198157 4.00E-83 polydomain protein 441 1 271 70 882 gl3898617 1.OOE-l42 serine/threonine protein kinase SSTK 441 1 271 70 882 g13540326 1.OOE-l42 serine/threonine kinase FKSG82 441 1 271 70 882 gl3898619 1.OOE-l40 serine/threonine protein kinase SSTK 442 2 311 743 1675 g8979743 1.OOE-l60 Band4.1-like5 protein TABLE 7 - ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 442 2 311 743 1675 gl 3278193 1. OOE-l 53 Similar to EHM2 gene 442 2 31 1 743 1675 g 10434740 1. OOE-l 40 unnamed protein product 443 2 529 416 2002 g 12834087 1. OOE-l 55 putative 443 2 529 416 2002 g2463628 ό.OOE-46 putative monocarboxylate transporter 443 2 529 416 2002 g7328162 1.00E-40 hypothetical protein 444 1 335 4 1008 gl 3159480 1. OOE-l 28 Translation may initiate at the ATG codon at nucleotides 40-42 or the ATG at nucleotides 43-45 444 335 4 1008 g9229906 5.00E-35 fibrinogen-like protein 444 335 4 1008 g387156 8.00E-33 flbrinogen-like protein 445 329 196 1 182 g4582324 0 dJ708F5.1 (PUTATIVE novel Collagen alpha 1 LIKE protein) 445 329 196 1 182 g 12052774 0 hypothetical protein 445 329 196 1 182 g2326442 1.00E-38 collagen type XII alpha 1 chain 446 2 395 1 10 1294 g 12642596 0 nuclear receptor co-repressor/HDAC3 complex subunit TBLR1 446 2 395 no 1294 g 10434648 0 unnamed protein product 446 2 395 no 1294 g 12006104 0 IRA1 447 1 163 1 489 gl 2858551 7.00E-67 putative 447 1 163 1 489 g 12805285 7.00E-67 Similar to ribosomal protein S27a 447 1 163 1 489 g 1050756 7.00E-67 fusion protein: ubiquitin (bases 43_513); ribosomal protein S27a (bases 217.532) 448 3 78 330 563 g8699209 5.00E-06 cyclophilin A 448 3 78 330 563 g50621 5.00E-06 cyclophilin (AA 1 - 164) 448 3 78 330 563 g49496 5.00E-06 cyclophilin (AA 1-164) 449 314 277 1218 g 12844770 1. OOE-l 30 putative 449 314 277 1218 gl 2861366 1. OOE-l 27 putative 449 314 277 1218 g 12857383 7.00E-50 putative 450 130 181 570 g2843171 4.00E-06 zinc finger protein 450 130 181 570 g5817149 5.00E-06 hypothetical protein 450 130 181 570 g 10434142 5.00E-06 unnamed protein product 451 176 697 1224 g 13383265 1.00E-63 actin related protein 451 176 697 1224 g 13938319 3.00E-62 Unknown (protein for MGC: 15664) 451 176 697 1224 g 12840619 2.00E-51 putative 452 3 671 3 2015 g 12698057 1. OOE-l 68 KIAA1756 protein TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 452 3 671 3 2015 g 1 177322 1. OOE-l 24 CPG2 protein 452 3 671 3 2015 g 10728577 1.00E-82 Msp-300 gene product 453 3 293 3 881 g4235148 8.00E-85 BC41195J 453 3 293 3 881 g 14165525 7.00E-71 Similar to CG8500 gene product 453 3 293 3 881 g 14388336 2.00E-70 hypothetical protein 455 253 478 1236 g 14424576 1. OOE-l 18 hypothetical protein FU21963 455 253 478 1236 g 10438188 1. OOE-l 18 unnamed protein product 455 253 478 1236 g 14025162 3.00E-57 acetyl-coa synthetase 457 125 529 903 g 12859335 1.00E-26 putative 457 125 529 903 g 12858578 1.00E-26 putative 457 125 529 903 g 12843085 ό.OOE-21 putative 458 394 577 1758 g 14533376 1. OOE-l 48 (AX151207) unnamed protein product 458 394 577 1758 gl 1762100 1. OOE-l 44 myo-inositol 1 -phosphate synthase 458 394 577 1758 g3108053 1. OOE-l 44 myo-inositol 1 -phosphate synthase; INOl 459 3 149 1 137 1583 g 12053149 2.00E-39 hypothetical protein 460 2 323 122 1090 g7297059 3.00E-06 CG91 17 gene product 461 3 200 387 986 g 13365897 1.00E-82 hypothetical protein 461 3 200 387 986 g2636109 2.00E-24 similar to metabolite transport protein 461 3 200 387 986 g 1894771 2.00E-24 product highly similar to metabolite transport proteins 462 2 406 701 1918 g 12697482 1. OOE-l 21 dJ583Pl 5.7.2 (novel zinc finger protein similar to rat RIN ZF) 462 2 406 701 1918 g 12855580 1.00E-81 putative 462 2 406 701 1918 g 12847599 7.00E-78 putative 463 3 181 102 644 g 13879442 2.00E-78 Similar to RIKEN cDNA 2310035M22 gene 463 3 181 102 644 g 12848905 2.00E-78 putative 463 3 181 102 644 g 12855490 1.00E-73 putative 464 3 137 69 479 gl l231085 7.00E-29 hypothetical protein 464 3 137 69 479 g 10998425 6.00E-09 NORPEG-like protein 464 3 137 69 479 gl 0937641 6.00E-09 ankycorbin 465 2 278 218 1051 gl 2861800 1. OOE-l 1 1 putative TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 465 2 278 218 1051 g3878713 2.00E-38 (Z46935) weak similarity with quinone oxidoreductase, contains similarity to Pfam domain: PF00107 (Zinc-binding dehydrogenases), Score=-80.ό, E- value=6.2e-06, N=l -cDNA EST ykl64b4.5 comes from this gene-cDNA EST ykl64b4.3 comes from this gene-cDNA EST yk264f3.5 comes from this 465 2 278 218 1051 g9948219 4.00E-36 conserved hypothetical protein 467 1 142 118 543 g4559318 4.00E-17 BC273239J 467 1 142 118 543 g186774 9.00E-17 zinc finger protein 467 1 142 118 543 gl017722 9.00E-17 repressor transcriptional factor 468 3 126 78 455 g9963804 5.00E-47 zinc finger protein ZNF286 468 3 126 78 455 g14017965 5.00E-47 KIAA1874 protein 468 3 126 78 455 g5640017 2.00E-46 zinc finger protein ZFP1 13 469 3 246 228 965 g13676461 1.00E-45 hypothetical protein 469 3 246 228 965 g4589566 1.00E-45 KIAA0961 protein 469 3 246 228 965 g487787 2.00E-37 zinc finger protein ZNF140 470 1 107 40 360 g14348591 2.00E-28 KRAB zinc finger protein 470 1 107 40 360 g7959207 1.00E-27 KIAA 1473 protein 470 1 107 40 360 g186774 4.00E-27 zinc finger protein 471 3 357 3 1073 g12052983 1.OOE-l67 hypothetical protein 471 3 357 3 1073 g14042293 1.OOE-l35 unnamed protein product 471 3 357 3 1073 g5262560 1.00E-113 hypothetical protein 472 3 90 3 272 g13752754 2.00E-16 zinc finger l l l l 472 3 90 3 272 g14348588 9.00E-15 KRAB zinc finger protein 472 3 90 3 272 g12654015 9.00E-15 Similar to hypothetical protein FU10891 473 295 885 g14495650 1.00E-75 (BC009433) zinc finger protein 331; zinc finger protein 463 473 295 885 g8575775 1.00E-75 KRAB zinc finger protein 473 295 885 g13939858 1.00E-75 RITA 474 195 585 g7020503 9.00E-68 unnamed protein product 474 195 585 g8453103 1.00E-67 zinc finger protein 474 195 585 g8099348 3.00E-67 zinc finger protein 475 2 232 257 952 g14042293 4.00E-53 unnamed protein product 475 2 232 257 952 g14042850 3.00E-47 unnamed protein product 475 2 232 257 952 g12052983 6.00E-38 hypothetical protein TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 476 2 282 2 847 g10440398 1.00E-93 FU00032 protein 476 2 282 2 847 g10047297 1.00E-93 KIAA161 1 protein 476 2 282 2 847 g10436789 8.00E-93 unnamed protein product 477 3 149 3 449 g12656631 7.O0E-20 Kruppel-like zinc finger protein GLIS2 477 3 149 3 449 g13507039 2.00E-19 Gli-Kruppel zinc-finger protein NKL 477 3 149 3 449 g13507037 2.00E-19 Gli-Kruppel zinc-finger protein NKL 478 3 283 3 851 g13623633 1.OOE-l 74 Unknown (protein for MGC: 13105) 478 3 283 3 851 g488555 3.00E-98 zinc finger protein ZNF135 478 3 283 3 851 g10437767 9.00E-97 unnamed protein product 479 3 264 3 794 gό807587 1.OOE-l 24 hypothetical protein 479 3 264 3 794 g5931821 1.OOE-l 24 dJ228H13.3 (zinc finger protein) 479 3 264 3 794 g488555 1.00E-96 zinc finger protein ZNF135 480 201 430 1032 g3540177 1.OOE-l 17 F23269.2 480 201 430 1032 g5080758 6.00E-92 BC331 191J 480 201 430 1032 g12855931 1.00E-55 putative 481 283 880 1728 gl4017871 1.OOE-l43 KIAA1827 protein 481 283 880 1728 g10436789 2.00E-97 unnamed protein product 481 283 880 1728 g13752754 1.00E-95 zinc finger l l l l 482 2 101 131 433 g14042373 1.00E-24 unnamed protein product 482 2 101 131 433 g1389741 7.00E-24 KRAB/zinc finger suppressor protein 1 482 2 101 131 433 g9800824 2.00E-20 bA179N14.1 (novel zinc finger protein) 483 1 101 112 414 g13937999 3.00E-48 Similar to DNA-binding protein 483 1 101 112 414 g3329372 1.00E-34 DNA-binding protein 483 1 101 112 414 g12052732 3.00E-34 hypothetical protein 484 2 297 215 1105 g12862320 2.00E-51 WDC146 486 3 108 462 785 g12856025 1.00E-51 putative 486 3 108 462 785 g12846941 4.00E-37 putative 486 3 108 462 785 g13938537 2.00E-36 Similar to RIKEN CDNA 4933430F16 gene 487 2 122 122 487 g4235144 4.00E-47 BC39498J 487 2 122 122 487 g4235143 7.00E-34 BC39498_3 487 2 122 122 487 g8163824 4.00E-30 krueppel-like zinc finger protein HZF2 488 1 182 148 693 g12854977 1.OOE-41 putative TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 488 1 182 148 693 g7267246 1.00E-21 putative adenosine deaminase 488 1 182 148 693 g7299138 1. OOE-l 6 CGI 1 94 gene product 489 2 1 14 293 634 g5262523 3.00E-19 hypothetical protein 489 2 1 14 293 634 g340170 3.00E-19 orotidine 5'-monophosphate decarboxylase (EC 4.1.1.23) 489 2 1 14 293 634 g340168 3.00E-19 UMP synthase 490 3 415 3 1247 g2689442 0 R28830J 490 3 415 3 1247 g 1572600 1. OOE-l 72 Zikl 490 3 415 3 1247 g 12652759 1. OOE-l 41 hypothetical protein FU20557 491 3 43 348 476 g 12052884 3.00E-06 hypothetical protein 491 3 43 348 476 g7023332 4.00E-06 unnamed protein product 491 3 43 348 476 g 183002 6.00E-05 guanylate binding protein isoform 1 492 1 134 49 450 g220637 4.00E-52 zinc finger protein 492 1 134 49 450 g5730196 2.00E-51 Kruppel-type zinc finger 492 1 134 49 450 g 14456631 8.00E-51 dJ54B20.4 (novel KRAB box containing C2H2 type zinc finger protein) 493 3 239 3 719 g 14042330 2.00E-96 unnamed protein product 493 3 239 3 719 g 10954044 8.00E-92 KRAB zinc finger protein ZFQR 493 3 239 3 719 g 10442700 8.00E-92 zinc-finger protein ZBRK1 495 2 185 134 688 g 13560888 2.00E-38 EZFIT-related protein 1 495 2 185 134 688 g7243243 2.00E-37 KIAA1431 protein 495 2 185 134 688 g4567178 5.00E-35 R31665_2 (AA 1- 673 ) 496 1 277 178 1008 g4589588 4.00E-67 KIAA0972 protein 496 1 277 178 1008 g498152 4.00E-51 ha0946 protein is Kruppel-related. 496 1 277 178 1008 g6467204 3.00E-38 gonadotropin inducible transcription repressor-3 497 3 241 3 725 g 14043841 3.00E-41 Unknown (protein for MGC: 14429) 497 3 241 3 725 g 14042293 6.00E-41 unnamed protein product 497 3 241 3 725 g 12052983 2.00E-40 hypothetical protein 498 2 251 1139 1891 g 12052983 1. OOE-l 14 hypothetical protein 498 2 251 1139 1891 g5262560 4.00E-68 hypothetical protein 498 2 251 1139 1891 g 10434856 1.00E-61 unnamed protein product 499 3 282 54 899 g5080758 1. OOE-l 03 BC331 191J 499 3 282 54 899 g3540177 1. OOE-l 03 F23269_2 499 3 282 54 899 g 12855931 1.00E-58 putative TABLE 7 SEQ ID NO: Frame Length Start Stop Gl Number Probability Score Annotation 500 1 442 28 1353 g 12652727 0 Unknown (protein for IMAGE:3352566) 500 1 442 28 1353 g488555 1.00E-97 zinc finger protein ZNF135 500 1 442 28 1353 g3378094 1.00E-95 KRAB domain zinc finger protein 501 3 292 3 878 g488551 1.00E-97 zinc finger protein ZNF132 501 3 292 3 878 g 1354341 2.00E-97 Similar to zinc finger protein 304 501 3 292 3 878 g 1 1 9604 3.00E-97 zinc finger protein C2H2-25 502 166 498 g 12804419 2.00E-65 Unknown (protein for MGC: 1 136) 502 166 498 g 12844790 5.00E-64 putative 502 166 498 gl31 1 1895 3.00E-33 Unknown (protein for MGC2627) 504 406 1218 g 12053281 0 hypothetical protein 504 406 1218 gl 2836135 1. OOE-l 67 putative 504 406 1218 g3043598 2.00E-64 KIAA0537 protein 505 332 996 g 10438696 1. OOE-l 40 unnamed protein product 505 332 996 g 12847740 7.00E-1 1 putative ) o 505 332 996 g7022551 1.00E-09 unnamed protein product o 506 2 183 2 550 g4105619 1.00E-94 SPAF 506 2 183 2 550 g 12847023 1.00E-94 putative 506 2 183 2 550 g7297973 5.00E-67 CG5776 gene product TABLE 8 Program Description Reference Parameter Threshold ABI FACTURA A program that removes vector sequences and masks Applied Biosystems, Foster City, CA ambiguous bases in nucleic acid sequences ABI/PARACEL FDF A Fast Data Finder useful in comparing and annotating Applied Biosystems, Foster City, CA, Paracel Mismatch <50 % amino acid or nucleic acid sequences Inc , Pasadena, CA ABI AutoAssembler A program that assembles nucleic acid sequences Applied Biosystems, Foster City, CA BLAST A Basic Local Alignment Search Tool useful in sequence Altschul, S F et al (1990) J Mol Biol 215 403- ESTs Probability value= 1 0E-8 or less, similarity search for amino acid and nucleic acid 410, Altschul, S F et al (1997) Nucleic Acids Full Length sequences Probability valuer sequences BLAST includes five functions blastp, Res 25 3389-3402 l OE-lO or less blastn, blastx, tblastn, and tblastx FASTA A Pearson and Lipman algorithm that searches for Pearson, W R and D J Lipman (1988) Proc ESTs fasta E value=l 06E-6, Assembled similarity between a query sequence and a group of Natl Acad Sci USA 85 2444-2448, Pearson, ESTs fasta Identιty= 95% or greater and sequences of the same type FASTA compπses as least W R (1990) Methods Enzymol 183 63-98, and Match length=200 bases or greater, fastx E five functions fasta, tfasta, fastx, tfastx, and ssearch Smith, T F and M S Waterman (1981) Adv value=l 0E-8 or less, Full Length Appl Math 2 482-489 sequences fastx score= 100 or greater BLIMPS A BLocks IMProved Searcher that matches a sequence Henikoff. S and J G Henikoff (1991 ) Nucleic Probability value= 1 0E-3 or less against those in BLOCKS, PRINTS, DOMO, PRODOM, Acids Res 19 6565-6572, Henikoff, J G and S and PFAM databases to search for gene families, Henikoff (1996) Methods Enzymol 266 88-105, sequence homology, and structural fingerprint regions and Attwood, T K et al (1997) J Chem Inf Comput Sci 37 417-424 HMMER An algorithm for searching a query sequence against Krogh, A et al (1994) J Mol Biol 235 1501- PFAM hits Probability value= 1 OE-3 or hidden Markov model (HMM)-based databases of 1531, Sonnhammer, E L L et al (1988) Nucleic less, protein family consensus sequences, such as PFAM Acids Res 26320-322, Durbin, R et al (1998) Signal peptide hits Score= 0 or greater Our World View, in a Nutshell, Cambridge Univ Press, pp 1 350 ProfileScan An algorithm that searches for structural and sequence Gribskov, M et al (1988) CABIOS 4 61-66, Normalized quality score≥GCG-specified motifs in protein sequences that match sequence patterns Gribskov, M et al (1989) Methods Enzymol "HIGH" value for that particular Prosite defined in Prosite 183 146-159, Bairoch, A et al (1997) Nucleic motif Generally, score=l 4-2 1 Acids Res 25 217 221 TABLE 8 Program Descnption Reference Parameter Threshold Phred A base-calling algorithm that examines automated Ewing, B et al (1998) Genome Res 8 175-185, sequencer traces with high sensitivity and probability Ewing, B and P Green (1998) Genome Res 8 186-194 Phrap A Phils Revised Assembly Program including SWAT Smith, T F and M S Waterman (1981) Adv Score= 120 or greater, and CrossMatch, programs based on efficient Appl Math 2 482-489, Smith, T F and M S Match length= 56 or greater implementation of the Smith-Waterman algorithm, Waterman (1981) J Mol Biol 147 195-197, useful in searching sequence homology and assembling and Green, P , University of Washington, DNA sequences Seattle, WA Consed A graphical tool for viewing and editing Phrap Gordon, D et al (1998) Genome Res 8 195 assemblies 202 SPScan A weight matrix analysis program that scans protein Nielson, H et al (1997) Protein Engineering Score=3 5 or greater sequences for the presence of secretory signal peptides 10 1-6, Claveπe, J M and S Audic (1997) CABIOS 12 431 439 TMAP A program that uses weight matrices to delineate Persson, B and P Argos (1994) J Mol Biol transmembrane segments on protein sequences and 237 182-192, Persson, B and P Argos (1996) determine orientation Protein Sci 5 363-371 TMHMMER A program that uses a hidden Markov model (HMM) to Sonnhammer, E L et al (1998) Proc Sixth Intl delineate transmembrane segments on protein sequences Conf On Intelligent Systems for Mol Biol , and determine orientation Glasgow et al , eds , The Am Assoc for Artificial Intelligence (AAAI) Press, Menlo Park, CA, and MIT Press, Cambπdge, MA, pp 175-182 Motifs A program that searches amino acid sequences for Bairoch, A et al (1997) Nucleic Acids Res patterns that matched those defined in Prosite 25 217-221, Wisconsin Package Program Manual, version 9, page M51-59, Genetics Computer Group, Madison, WI

Claims: CLAIMS What is claimed is: 1. An isolated polynucleotide selected from the group consisting of: a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1 -252, b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1 -252, c) a polynucleotide complementary to the polynucleotide of a), d) a polynucleotide complementary to the polynucleotide of b), and e) an RNA equivalent of a)-d). 2. An isolated polynucleotide of claim 1 , selected from the group consisting of SEQ ID NO: l- 252. 3. An isolated polynucleotide comprising at least 30 contiguous nucleotides of a polynucleotide of claim 1. 4. An isolated polynucleotide comprising at least 60 contiguous nucleotides of a polynucleotide of claim 1. 5. A composition for the detection of expression of disease detection and treatment polynucleotides comprising at least one of the polynucleotides of claim 1 and a detectable label. 6. A method for detecting a target polynucleotide in a sample, said target polynucleotide having a sequence of a polynucleotide of claim 1 , the method comprising: a) amplifying said target polynucleotide or fragment thereof using polymerase chain reaction amplification, and b) detecting the presence or absence of said amplified target polynucleotide or fragment thereof, and, optionally, if present, the amount thereof. 7. A method for detecting a target polynucleotide in a sample, said target polynucleotide having a sequence of a polynucleotide of claim 1 , the method comprising: 303 a) hybridizing the sample with a probe comprising at least 20 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target polynucleotide or fragments thereof, and b) detecting the presence or absence of said hybridization complex, and, optionally, if present, the amount thereof. 8. A method of claim 7, wherein the probe comprises at least 30 contiguous nucleotides. 9. A method of claim 7, wherein the probe comprises at least 60 contiguous nucleotides. 10. A recombinant polynucleotide comprising a promoter sequence operably linked to a polynucleotide of claim 1. 11. A cell transformed with a recombinant polynucleotide of claim 10. 12. A transgenic organism comprising a recombinant polynucleotide of claim 10. 13. A method for producing a disease detection and treatment polypeptide encoded by a polynucleotide of claim 1, the method comprising: a) culturing a cell under conditions suitable for expression of the disease detection and treatment polypeptide, wherein said cell is transformed with a recombinant polynucleotide comprising a promoter sequence operably linked to a polynucleotide of claim 1, and b) recovering the disease detection and treatment polypeptide so expressed. 14. A method of claim 13, wherein the polypeptide has an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. 15. An isolated disease detection and treatment polypeptide (MDDT) encoded by at least one of the polynucleotides of claim 2. 16. A method of screening for a test compound that specifically binds to the polypeptide of claim 15, the method comprising: 304 a) combining the polypeptide of claim 15 with at least one test compound under suitable conditions, and b) detecting binding of the polypeptide of claim 15 to the test compound, thereby identifying a compound that specifically binds to the polypeptide of claim 15. 17. A microarray wherein at least one element of the microarray is a polynucleotide of claim 18. A method for generating a transcript image of a sample which contains polynucleotides, the method comprising: a) labeling the polynucleotides of the sample, b contacting the elements of the microarray of claim 17 with the labeled polynucleotides of the sample under conditions suitable for the formation of a hybridization complex, and c) quantifying the expression of the polynucleotides in the sample. 19. A method for screening a compound for effectiveness in altering expression of a target polynucleotide, wherein said target polynucleotide comprises a polynucleotide sequence of a polynucleotide of claim 1 , the method comprising: a) exposing a sample comprising the target polynucleotide to a compound, under conditions suitable for the expression of the target polynucleotide, b) detecting altered expression of the target polynucleotide, and c) comparing the expression of the target polynucleotide in the presence of varying amounts of the compound and in the absence of the compound. 20. A method for assessing toxicity of a test compound, said method comprising: a) treating a biological sample containing nucleic acids with the test compound, b) hybridizing the nucleic acids of the treated biological sample with a probe comprising at least 20 contiguous nucleotides of a polynucleotide of claim 1 under conditions whereby a specific hybridization complex is formed between said probe and a target polynucleotide in the biological sample, said target polynucleotide comprising a polynucleotide sequence of a polynucleotide of claim 1 or fragment thereof, c) quantifying the amount of hybridization complex, and d) comparing the amount of hybridization complex in the treated biological sample with the amount of hybridization complex in an untreated biological sample, wherein a 305 difference in the amount of hybridization complex in the treated biological sample is indicative of toxicity of the test compound. 21. An array comprising different nucleotide molecules affixed in distinct physical locations on a solid substrate, wherein at least one of said nucleotide molecules comprises a first oligonucleotide or polynucleotide sequence specifically hybridizable with at least 30 contiguous nucleotides of a target polynucleotide, and wherein said target polynucleotide is a polynucleotide of claim 1. 22. An array of claim 21 , wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 30 contiguous nucleotides of said target polynucleotide. 23. An array of claim 21 , wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 60 contiguous nucleotides of said target polynucleotide 24. An array of claim 21 , wherein said first oligonucleotide or polynucleotide sequence is completely complementary to said target polynucleotide. 25. An array of claim 21, which is a microarray. 26. An array of claim 21 , further comprising said target polynucleotide hybridized to a nucleotide molecule comprising said first oligonucleotide or polynucleotide sequence. 27. An array of claim 21 , wherein a linker joins at least one of said nucleotide molecules to said solid substrate. 28. An array of claim 21, wherein each distinct physical location on the substrate contains multiple nucleotide molecules, and the multiple nucleotide molecules at any single distinct physical location have the same sequence, and each distinct physical location on the substrate contains nucleotide molecules having a sequence which differs from the sequence of nucleotide molecules at another distinct physical location on the substrate. 29. An isolated polypeptide selected from the group consisting of: a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% 306 identical to an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. 30. An isolated polypeptide of claim 29, having a sequence selected from the group consisting of SEQ ID NC.253-506. 31 . An isolated polynucleotide encoding a polypeptide of claim 29. 32. An isolated polynucleotide encoding a polypeptide of claim 30. 33. An isolated polynucleotide of claim 32, having a sequence selected from the group consisting of SEQ ID NO: 1 -252. 34. An isolated antibody which specifically binds to a disease detection and treatment polypeptide of claim 29. 35. A diagnostic test for a condition or disease associated with the expression of MDDT in a biological sample, the method comprising: a) combining the biological sample with an antibody of claim 34, under conditions suitable for the antibody to bind the polypeptide and form an antibody:polypeptide complex, and b) detecting the complex, wherein the presence of the complex correlates with the presence of the polypeptide in the biological sample. 36. The antibody of claim 34, wherein the antibody is: a) a chimeric antibody, b) a single chain antibody, c) a Fab fragment, d) a F(ab') 2 fragment, or e) a humanized antibody. 307 37. A composition comprising an antibody of claim 34 and an acceptable excipient. 38. A method of diagnosing a condition or disease associated with the expression of MDDT in a subject, comprising administering to said subject an effective amount of the composition of claim 37. 39. A composition of claim 37, wherein the antibody is labeled. 40. A method of diagnosing a condition or disease associated with the expression of MDDT in a subject, comprising administering to said subject an effective amount of the composition of claim 39. 41. A method of preparing a polyclonal antibody with the specificity of the antibody of claim 34, the method comprising: a) immunizing an animal with a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, or an immunogenic fragment thereof, under conditions to elicit an antibody response, b) isolating antibodies from said animal, and c) screening the isolated antibodies with the polypeptide, thereby identifying a polyclonal antibody which binds specifically to a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. 42. An antibody produced by a method of claim 41. 43. A composition comprising the antibody of claim 42 and a suitable carrier. 44. A method of making a monoclonal antibody with the specificity of the antibody of claim 34, the method comprising: a) immunizing an animal with a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506, or an immunogenic fragment thereof, under conditions to elicit an antibody response, b) isolating antibody producing cells from the animal, c) fusing the antibody producing cells with immortalized cells to form monoclonal antibody-producing hybridoma cells, 308 d) culturing the hybridoma cells, and e) isolating from the culture monoclonal antibody which binds specifically to a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. 45. A monoclonal antibody produced by a method of claim 44. 46. A composition comprising the antibody of claim 45 and a suitable carrier. 47. The antibody of claim 34, wherein the antibody is produced by screening a Fab expression library. 48. The antibody of claim 34, wherein the antibody is produced by screening a recombinant immunoglobulin library. 49. A method of detecting a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506 in a sample, the method comprising: a) incubating the antibody of claim 34 with a sample under conditions to allow specific binding of the antibody and the polypeptide, and b) detecting specific binding, wherein specific binding indicates the presence of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506 in the sample. 50. A method of purifying a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506 from a sample, the method comprising: a) incubating the antibody of claim 34 with a sample under conditions to allow specific binding of the antibody and the polypeptide, and b) separating the antibody from the sample and obtaining the purified polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:253-506. 51. A composition comprising a polypeptide of claim 29 and a pharmaceutically acceptable excipient. 52. A composition of claim 51, wherein the polypeptide has an amino acid sequence of SEQ ID NO:253-506. 309 53. A method for treating a disease or condition associated with decreased expression of functional MDDT, comprising administering to a patient in need of such treatment the composition of claim 51. 54. A method for screening a compound for effectiveness as an agonist of a polypeptide of claim 29, the method comprising: a) exposing a sample comprising a polypeptide of claim 29 to a compound, and b) detecting agonist activity in the sample. 55. A composition comprising an agonist compound identified by a method of claim 54 and a pharmaceutically acceptable excipient. 56. A method for treating a disease or condition associated with decreased expression of functional MDDT, comprising administering to a patient in need of such treatment a composition of claim 55. 57. A method for screening a compound for effectiveness as an antagonist of a polypeptide of claim 29, the method comprising: a) exposing a sample comprising a polypeptide of claim 29 to a compound, and b) detecting antagonist activity in the sample. 58. A composition comprising an antagonist compound identified by a method of claim 57 and a pharmaceutically acceptable excipient. 59. A method for treating a disease or condition associated with overexpression of functional MDDT, comprising administering to a patient in need of such treatment a composition of claim 58. 60. A method of screening for a compound that modulates the activity of the polypeptide of claim 29, said method comprising: a) combining the polypeptide of claim 29 with at least one test compound under conditions permissive for the activity of the polypeptide of claim 29, b) assessing the activity of the polypeptide of claim 29 in the presence of the test compound, and c) comparing the activity of the polypeptide of claim 29 in the presence of the test compound with the activity of the polypeptide of claim 29 in the absence of the test 310 compound, wherein a change in the activity of the polypeptide of claim 29 in the presence of the test compound is indicative of a compound that modulates the activity of the polypeptide of claim 29. 31 1

Inventors: ALTUS CHRISTINA M, CHALUP MICHAEL S, DUFOUR GERARD E, JACKSON STUART, LINCOLN STEPHEN E, ALTUS, CHRISTINA, M., CHALUP, MICHAEL, S., DUFOUR, GERARD, E., JACKSON, STUART, LINCOLN, STEPHEN, E.
Applicants: ALTUS CHRISTINA M, CHALUP MICHAEL S, DUFOUR GERARD E, INCYTE GENOMICS INC, JACKSON STUART, LINCOLN STEPHEN E, ALTUS, CHRISTINA, M., CHALUP, MICHAEL, S., DUFOUR, GERARD, E., INCYTE GENOMICS, INC., JACKSON, STUART, LINCOLN, STEPHEN, E.
Application year: 2001
Main classification: C12Q1
IPC codes: A61K38, A61K48, C12N15, C12Q1