TERNARY LIGAND COMPLEXES USEFUL AS RADIOPHARMACEUTICALS

Abstract: This invention relates to novel highly functionalized phosphine ligands as ancillary ligands in radiopharmaceuticals. Also, this invention provides radiopharmaceuticals comprised of highly functionalized phosphine ligated <99m>Tc labeled HYNIC-conjugated biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. The invention also provides methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer.

Description: TERNARY LIGAND COMPLEXES USEFUL AS RADIOPHARMACEUTICALS FIELD OF THE INVENTION This invention relates to novel highly 5 functionalized phosphine ligands as ancillary ligands in radiopharmaceuticals which are useful as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer and kits containing the same. The 10 radiopharmaceuticals are comprised of highly functionalized phosphine ligated ^^^ c-labeled biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. The invention also 15 provides methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer. 20. BACKGROUND OF THE INVENTION Radiopharmaceuticals are drugs containing a radionuclide, and are used routinely in nuclear medicine department for the diagnosis or therapy of various diseases. They are mostly small organic or inorganic 25 compounds with definite composition. They can also be macromolecules such as antibodies and antibody fragments that are not stoichiometrically labeled with a radionuclide. Radiopharmaceuticals form the chemical basis for nuclear medicine, a group of techniques used 30 for diagnosis and therapy of various diseases. The in vivo diagnostic information is obtained by intravenous injection of the radiopharmaceutical and determining its biodistribution using a gamma camera. The biodistribution of the radiopharmaceutical depends on the physical and chemical properties of the radiopharmaceutical and can be used to obtain information about the presence, progression, and the state of disease. Radiopharmaceuticals can be divided into two primary classes : those whose biodistribution is determined exclusively by their chemical and physical properties; and those whose ultimate distribution is determined by their receptor binding or other biological interactions. The latter class is often called target- specific radiopharmaceuticals. In general, a target specific radiopharmaceutical can be divided into four parts: a targeting molecule, a linker, a Bifunctional Chelator (BFC) , and a radionuclide. The targeting molecule serves as a vehicle, which carries the radionuclide to the receptor site at the diseased tissue. The targeting molecules can be macromolecules such as antibodies. They can also be small biomolecules (Q) : peptides, peptidomimetics, and non-peptide receptor ligands. The choice of biomolecule depends upon the targeted disease or disease state. The radionuclide is the radiation source. The selection of radionuclide depends on the intended medical use (diagnostic or therapeutic) of the radiopharmaceutical. Between the targeting molecule and the radionuclide is the BFC, which binds strongly to the metal ion via several coordination bonds and is covalently attached to the targeting molecule either directly or through a linker. Selection of a BFC is largely determined by the nature and oxidation state of the metallic radionuclide. The linker can be a simple hydrocarbon chain or a long poly (ethylene glycol) (PEG) , which is often used for modification of pharmacokinetics . Sometimes, a metabolizeable linker is used to increase the blood clearance and to reduce the background activity, thereby improving the target-to- background ratio . The use of metallic radionuclides offers many opportunities for designing new radiopharmaceuticals by modifying the coordination environment around the metal with a variety of chelators. The coordination chemistry of the metallic radionuclide will determine the geometry of the metal chelate and the solution stability of the radiopharmaceutical. Different metallic radionuclides have different coodination chemistries, and require BFCs with different donor atoms and ligand frameworks. For "metal essential" radiopharmaceuticals, the biodistribution is exclusively determined by the physical properties of the metal chelate. For target- specific radiopharmaceuticals, . the "metal tag" is not totally innocent because the target uptake and biodistribution will be affected by the metal chelate, the linker, and the targeting biomolecule. This is especially true for radiopharmaceuticals based on small molecules such as peptides due to the fact that in many cases the metal chelate contributes greatly to the overall size and molecular weight. Therefore, the design and selection of the BFC is very important for the development of a new radiopharmaceutical. A BFC can be divided into three parts : a binding unit, a conjugation group, and a spacer (if necessary) . An ideal BFC is that which is able to form a stable 99m r p c complex in high yield at very low concentration of the BFC-Q conjugate. There are several requirements for an ideal BFC. First, the binding unit can selectively stabilize an intermediate or lower oxidation state of Tc so that the 99:mτc complex is not subject to redox reactions; oxidation state changes are often accompanied by transchelation of 99m Tc f ro a 99mrp c _ BFC _ Ln _Q complex to the native chelating ligands in biological systems. Secondly, the BFC forms a 99m .r p c complex which has thermodynamic stability and kinetic inertness with respect to dissociation. Thirdly, the BFC forms a 99m > p c complex with a minimum number of isomers since different isomeric forms of the 9mrp c _ c }- Le T_ at:e ma y h ave significant impact on the biological characteristics of the 99m .rp c _ BFC-Ln-Q complex. Finally, the conjugation group can be easily attached to the biomolecule. In simple technetium complex radiopharmaceuticals such as 99^c-sestamibi, [99m Tc ( IBI) 6] + (MIBI = 2- methoxy-2-methylpropyl-isonitrile) and 9m r c -bicisate, [99m Tc0 (ECD) ] (ECD = I, I-ethylene dicycteine diethyl ester) , the ligand (MIBI or ECD) is always present in large excess. The main factor influencing the 99m .r p c _ labeling kinetics is the nature of the donor atoms and the radiolabeling conditions. For receptor-based target specific radiopharmaceuticals, however, the use of large amount of BFCA-Ln-Q may result in receptor site saturation, blocking the docking of the 9m r c -labeled BFC-Ln-Q, as well as unwanted side effects. In order to avoid these problems, the concentration of the BFC-Ln-Q in the radipharmaceutical kit has to be very low (10 ~ 6 - 10 ~ 5 M) . Otherwise, a post-labeling purification is often needed to remove excess unlabeled BFC-Ln-Q, which is time consuming and thus not amenable for clinical use. Compared to the total technetium concentration (~5 x 10 ~7 M) in 100 m C i of [99m Tc ] perteclιnetate (24 h prior-elution) , the BFC-Ln-Q is not in overwhelmingly excess. Therefore, the BFC attached to the biomolecule must have very high radiolabeling efficiency in order to achieve high specific activity, the amount of unlabeled BFC-Ln-Q conjugate used to synthesize the radiopharmaceutical . Various BFCs have been used for the 99m .r p c -iabeling of biomolecules, and have been extensively reviewed (Horn, R. K. and Katzenellenbogen, J. A. Nucl . Med. Biol . 1997, 24, 485; Dewanjee, M. K. Semin . Nucl . Med. 1990, 20, 5; Jurisson, et al Chem. Rev. 1993, 93, 1137; Dilworth, J. R. and Parrott, S. J. Chem. Soc . Rev. 1998, 27, 43; Liu, et al Bioconj . Chem . 1997, 8, 621; Liu, et al Pure & Appl . Chem. 1991, 63 , 427; Griffiths, et al Bioconj . Chem. 1992, 3, 91). The use of hydrazines and hydrazides as BFCs to modify proteins for labeling with radionuclides has been recently disclosed in Schwartz et al U.S. Pat. No. 5,206,370. For labeling with technetium-99m, the hydrazino-modified protein is reacted with a reduced technetium species, formed by reacting [99mr rc ]p er - ec ] ιne - a |- e i h a reducing agent in the presence of a chelating dioxygen ligand. The technetium is bonded through what are believed to be hydrazino or diazenido linkages with the coordination sphere completed by the coligands such as glucoheptonate and lactate. Bridger et al European Patent Application No. 93302712.0 discloses a series of functionalized aminocarboxylates and their use for the radiolabeling of hydrazino-modified proteins. The improvements are manifested by shorter reaction times and higher specific activities for the radiolabeled protein. The best example is tricine. Archer et al, European Patent application 90914225.9 discloses a series of 99 rrι c complexes having a ternary ligand system comprised of a hydrazino or diazenido ligand, a phosphine ligand and a halide, in which the substituents on the hydrazido or diazenido ligand and those phosphine ligand can be independently varied. This disclosure does not teach or suggest how to achieve the superior control of biological properties that will result from a ternary ligand system in which the substituents on the three types of ligands can be independently varied. In addition, the radiopharmaceuticals described by Archer et al are formed in low specific activity. Therefore, there remains a need for new ternary ligand systems which form radiopharmaceuticals with high specific activity. U.S. patent 5,744,120 discloses novel ternary ligand radiopharmaceutical complexes composed of a water soluble phosphine as one of the three ligands. These ternary ligand complexes are formed in good yield, exhibit high solution stability, and exist in a minimal number of isomeric forms . The phosphine coligand can be functionalized to control the physicochemical properties of the ternary ligand complexes. The extent of such control is dependent on the degree of functionalization of the phosphine coligands. Thus, it is desirable and advantageous to discover ternary ligand complexes composed of highly functionalized, neutral water-soluble phosphine coligands. SUMMARY OF THE INVENTION The present invention provides novel ternary 9m ι p c radiopharmaceuticals composed of: chelator-modified biomolecules, including Ilb/IIIa antagonists, tuftsin receptor antagonists, chemotactic peptides, vitronectin receptor antagonists and tyrosine kinase inhibitors, aminocarboxylates; and highly functionalized phosphine coligands. These radiopharmaceuticals are formed as minimal number of isomers, the relative ratio of which do not change with time. This invention provides novel radiopharmaceuticals and methods of using the same as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer. The radiopharmaceutical are comprised of highly functionalized phosphine ligated 99m .rp c η beled biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. The present invention further provides kits for the preparation of the radiopharmaceuticals . The highly functionalized phosphines contain hydroxy or polyhydroxy functionalities. These functionalities are of great interest because they can form neutral 99m r p c complexes. The highly functionalized phosphines can contain carboxy or polycarboxy functionalities, which are used to increase hydrophilicity and to improve blood clearance and renal excretion of the 99m rr< c _ι a ]oeled biomolecule. The highly functionalized phosphines can also contain metabolizeable ester or polyester functionalities and form neutral 99m > p c complexes (if there is no charge on the biomolecule) , which can cross the cell membrane and potentially bind intracellular receptors . Once inside the cell, hydrolysis of one or more ester groups forms a negatively charged 9m r p c _ S p ec i eS which can not be easily diffused out from the cell. In this way, the target cell uptake may be signi icantly improved. On the other hand, if the ester group is hydrolyzed in the blood, the negatively charged 9m r c -. S p ec j_ es j_ s expected to have faster and more renal clearance. Therefore, the introduction of the ester groups has two potential advantages: increase in target cell uptake and decrease in background. DETAILED DESCRIPTION OF THE INVENTION [1] Thus in a first embodiment, the present invention provides an ancillary ligand (A 2) of the formula: or pharmaceutically acceptable salt form thereof; wherein: R67 is independently selected, at each occurrence, from the group consisting of: C(0)R 68 , S(0) 2 R 68 , P(0)(OR 68 ), C(0)NR 68 R 69 , S(0) 2 NR 68 R 59 , and C(0)OR 68 ; R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , C2-10 alkenyl substituted with 1-5 R 70 and 0-2 R 70a , C2-10 alkynyl substituted with 1-5 R 70 and 0-2 R 70a , aryl substituted with 1-4 R 70 and 0-1 R 7 0a, C3--10 heterocycle substituted with 1-4 R 7 0 and 0-1 R 7 ^ a and C3-10 carbocycle substituted with 1-3 R 70 and 0-2 R 70a ; R^ is independently selected, at each occurrence, from the group consisting of: H, Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , C2-10 alkenyl substituted with 1-5 R 70 and 0-2 R 70a , C2-10 alkynyl substituted with 1-5 R 7 ^ and 0-2 R 70a , aryl substituted with 1-3 R 70 and 0-2 R ^ a , C3-10 heterocycle substituted with 1-4 R 7 0 and 0-1 R 7( ^ a , and C3--10 carbocycle substituted with 1-4 R 70 and 0-1 R 70 ; R ^ is independently selected, at each occurrence, from the group consisting of: -OR 7 l, -CO2R 7 -'-, -OC(=0)R 71 ,-OC(=0)OR 71 , -OCH2CO2R 71 , -NR 72 C(=0)OR 71 , -Sθ2R 71a , -Sθ3R 71 , - NR 72 S02R 71a , -Pθ3R 71a and Cl-10 alkyl substituted with 1-5 -OR 7 ^-; j > 70a i s independently selected, at each occurrence, from the group consisting of: =0, F, Cl, Br, I, -CF3, -CN, -NO2, -C(=0)R 71 , -C(=0)N(R 71 )2, -N(R 71 )3 + , -0C(=0)N(R 71 )2, -NR 71 C (=0) R 71 , -NR 72 C(=0)OR 71a , -NR 71 C(=0)N(R 71 )2, -NR 72 S02N(R 71 )2, -SO2N (R 71 ) 2. and -N(R 71 )2; R 71 is independently selected, at each occurrence, from the group consisting of: H and C -Cg alkyl substituted with 0-5 hydroxyl substituents ; R 71a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 0-5 hydroxyl substituents; and, R 72 is independently selected, at each occurrence, from the group consisting of: H and C -Cβ alkyl substituted with 0-5 hydroxyl substituents . [2] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 wherein: R 68 ig independently selected, at each occurrence, from the group consisting of: C1-10 alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , -CO2R 71 and C1-10 alkyl substituted with 1-5 -OR 71 . [3] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 wherein: R 67 is C(0)NR 68 R 69 ; R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70 , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 *- 1 is independently selected, at each occurrence, from the group consisting of: Ci alkyl substituted with -OR 71 , -OR 71 , -S03R 71a , and -CO2R 71 . [4] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 wherein : R 67 is C(0)NR 68 R 69 ; R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-6 alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5--6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 ^ is independently selected, at each occurrence, from the group consisting of: Ci alkyl substituted with -OR 71 , -OR 71 , -S03R 71a , -CO2R 71 . [5] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 wherein : R 67 is C(0)NR 68 R 69 ; R 68 is Ci-6 alkyl substituted with 1-5 R 70 and 0-2 R 70a ; R^ i hydrogen; R 70 is -OR 71 , -S03R 71 , -C02R 71 ; R 71 is H; and R 7 a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 1-5 hydroxyl substituents . [6] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci_3 alkyl substituted with 1-3 R 70 ; R69 is hydrogen; R 70 is -OR 71 , -S03R 71a , or -CO2R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and C1-2 alkyl substituted with 1-2 hydroxyl substituents. [7] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-2 alkyl substituted with 1-2 R 70 ; R^9 is hydrogen; R 70 is -OR 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl substituted with 1-2 hydroxyl substituents. [8] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 of the formula: R 67 is C(0)NR 68 R 6 9 ; R 68 is Ci-3 alkyl substituted with 1-3 R 70 ; R69 is hydrogen; R 70 is -S03R 71a or -C02R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Cχ-2 alkyl. [9] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Cι_3 alkyl substituted with 0-3 -OR 70 and 0-1 R 70a. R69 is hydrogen; R 70 is -C02R 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Ci-Cg alkyl substituted with 0-5 hydroxyl substituents. [10] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 of the formula: R 67 is C(0)NR 68 R 69 ; R6 8 is independently selected, at each occurrence, from the group consisting of: tetrohydropyranyl substituted with 1-4 R 70 and 0-1 R 70a , and tetrohydrofuranyl substituted with 1-3 R 70 and 0-1 R 71 ; Rδ9 is hydrogen; R 7 ^ is independently selected, at each occurrence, from the group consisting of: -OR 71 , and Ci alkyl substituted with -OR 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Ci-Cβ alkyl substituted with 0-5 hydroxyl substituents. [11] In another embodiment, the present invention provides an ancillary ligand according to embodiment 1 selected from the group: ; or pharmaceutically acceptable salts thereof [12] In another embodiment, the present invention provides a radiopharmaceutical comprising an ancillary ligand according to any one of embodiments 1-11, chelated with a radionuclide selected from the group consisting of : 99m TC 186 Re an( j 188 Re> [13] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein: R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5--6 heterocyclyl substituted with -OR 71 l-4 R 70 and 0-1 R 70 ; R 69 is H; and R 7 ^ is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , -CO2R 71 and Ci-6 alkyl substituted with 1-5 -OR 71 . [14] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12 wherein: R 67 is C(0)NR 68 R 69 ; R^ is independently selected, at each occurrence, from the group consisting of: Cχ-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , -CO2R 71 and Cχ-6 alkyl substituted with 1-5 -OR 71 . [15] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein: R 67 is C(0)NR 68 R 69 ; R68 is independently selected, at each occurrence, from the group consisting of: Ci-6 alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C 5 _g heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 ^ is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , -CO2R 71 and Ci-6 alkyl substituted with 1-5 -OR 71 . [16] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-6 alkyl substituted with 1-5 R 70 and 0-2 R 70a ; R69 i s hydrogen; R 70 is -OR 71 , -S03R 71a , -CO2R 71 ; R 71 is H; and R 71a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 1-5 hydroxyl substituents. [17] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is C1-3 alkyl substituted with 1-3 R 70 ; R6 is hydrogen; R 70 is -OR 71 , -S03R 71a , or -C02R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Cχ-2 alkyl substituted with 1-2 hydroxyl substituents . [18] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Cι_2 alkyl substituted with 1-2 R 70 ; R69 is hydrogen; R 70 is -OR 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Cι_2 alkyl substituted with 1-2 hydroxyl substituents. [19] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-3 alkyl substituted with 1-3 R 70 ; R6 is hydrogen; R 70 is -S03R 71a or -CO2R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl. [20] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Cι_3 alkyl substituted with 0-3R 70 and 0-1 R 70a ; R^9 is hydrogen; R 70 is -CO2R 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 0-5 hydroxyl substituents. [21] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein: the ancillary ligand is of the formula: R 67 is C(0)NR β8 R 69 ; p68 is independently selected, at each occurrence, from the group consisting of: tetrohydropyranyl substituted with 1-4 R 7 0 and 0-1 R 7 0 a , and tetrohydrofuranyl substituted with 1-3 R 70 and 0-1 R 71a ; R 69 is hydrogen; R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , and Ci alkyl substituted with -OR 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 0-5 hydroxyl substituents. [22] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 12, wherein the ancillary ligand (AL2) is selected from the group consisting of: and [23] In another embodiment, the present invention provides a radiopharmaceutical of formula: [(Q ) d'L n -Ch']χ-M t (A L ι ) γ ( A L 2 ) z (D or pharmaceutically acceptable salts thereof wherein, A 2 an ancillary ligand of any one of embodiments 1-11; ALI 1S a first ancillary ligand and is a dioxygen ligand or a functionalized aminocarboxylate ; Q is a biologically active group; d' is 1 to 20; L n is a linking group of formula: M 1 - [Y 1 (CR 55 R 56 ) f (Z 1 ) f iΥ 2 ] f ' -M 2 , M 1 is -[ (CH2)gZ 1 ]g'-(CR 55 R 5β ) g »-; M 2 is -(CR 55 R 56 )g"-[Z 1 (CH2)g]g'-; g is independently 0-10; g' is independently 0-1; g" is independently 0-10; f is independently 0-10; f is independently 0-10; f" is independently 0-1; Y 1 and Y 2 , at each occurrence, are independently selected from: a bond, 0, NR 56 , C=0, C(=0)0, OC(=0)0, C(=0)NH-, C=NR 56 , S, SO, S02 , SO3 , NHC(=0) , ( H)2C(=0), and (NH)2C=S; Z 1 is independently selected at each occurrence from a C6~Ci4 saturated, partially saturated, or aromatic carbocyclic ring system, substituted with 0-4 R^ 7 ; and a heterocyclic ring system, optionally substituted with 0-4 R^ 7 ; R 5 anc R56 are independently selected at each occurrence from: H, C1-C10 alkyl substituted with 0-5 R^ 7 , and alkaryl wherein the aryl is substituted with 0-5 R^ 7 ; R^ 7 is independently selected at each occurrence from the group: H, OH, NHR 58 , C(=0)R 58 , OC(=0)R 58 , OC(=0)OR 58 , C(=0)OR 58 , C(=0)NR 58 , -CN, SR 58 , SOR 58 , SO2R 58 . NHC(=0)R 58 , NHC(=0)NHR 58 , and NHC (=S)NHR 58 , alternatively, when attached to an additional molecule Q, R^ 7 is independently selected at each occurrence from the group: 0, NR 58 , C=0, C(=0)0, OC(=0)0, C(=0)N, C=NR 58 , S, SO, S02, SO3, NHC(=0), (NH)2C(=0), and (NH)2C=S; R^ 8 is independently selected at each occurrence from the group: H, C1-C6 alkyl, benzyl, and phenyl; x, y and z are independently 1 or 2; Mt is a transition metal radionuclide selected from the group: 99m TC 186 Re anα 188 Re . Ch' is a radionuclide metal chelator coordinated to transition metal radionuclide M , and is independently selected at each occurrence, from the group: R 40 N=N + =, R 0 R 41 N-N=, and R 0 N=N(H)-; R 0 is independently selected at each occurrence from the group: a bond to L n , Ci-Cio alkyl substituted with 0-3 R 52 , aryl substituted with 0-3 R52, cycloaklyl substituted with 0-3 R 52 , heterocycle substituted with 0-3 R52, heterocycloalkyl substituted with 0-3 R 52 , aralkyl substituted with 0-3 R 52 and alkaryl substituted with 0-3 R 52 ; R 41 is independently selected from the group: H, aryl substituted with 0-3 R 5 , Ci-Cio alkyl substituted with 0-3 R 52 , and a heterocycle substituted with 0- 3 R 52 ; R 52 is independently selected at each occurrence from the group: a bond to L n , =0, F, Cl, Br, I, -CF3 , - CN, -C02R 53 , -C(=0)R 53 , -C(=0)N(R 53 )2, -CHO, -CH2OR 53 , -OC(=0)R 53 , -OC(=0)OR 53 , -OR 53 , -OC(=0)N(R 53 )2, -NR 53 C(=0)R 53 , -N(R 53 )3 + , -NR 5 C (=0) OR 5 a , -NR 53 C (=0)N(R 53 ) 2. -NR 5 S02N(R 53 )2, -NR 54 S02R 53a , -SO3H, -Sθ2R 53a , -SR 53 , -S(=0)R 53a , -S02N(R 53 )2, -N(R 53 )2, -NHC(=NH)NHR 53 , -C (=NH) NHR 53 , =NOR 53' , N02 , -C(=0)NH0R 53 , -C(=0) NHNR 53 R 53a , -OCH2CO2H, and 2- (1-morpholino) ethoxy; R53 7 R53a ^ anα R 54 are each independently selected at each occurrence from the group: H, C1-C6 alkyl, and a bond to L n . [24] In another embodiment, the present invention provides a radiopharmaceutical embodiment 23 wherein: Q is a biomolecule selected from the group: Ilb/IIIa receptor antagonists, Ilb/IIIa receptor ligands, fibrin binding peptides, leukocyte binding peptides, chemotactic peptides, somatostatin analogs, selectin binding peptides, vitronectin receptor antagonists, and tyrosine kinase inhibitors; d' is 1 to 3; L n is: - (CR 55 R 56 ) g »- [Y 1 (CR 55 R 56 ) fY 2 ] f ' - (CR 55 R 5β ) g "-, g" is 0-5; f is 0-5; f is 1-5; Y 1 and Y 2 , at each occurrence, are independently selected from: 0, NR 56 , C=0, C (=0) 0, 0C(=0)0, C(=0)NH, C=NR 56 , S, SO, S02 , SO3 , NHC(=0), (NH)2C(=0), and (NH)2C=S; R55 and R 5 ^ are independently selected at each occurrence from: H, Ci-Cio alkyl and alkaryl; x and y are 1 ; Mt is 99m Tc; Ch' i R 40 N=N + = or R 0 R 41 N-N=; R 4 ^ is independently selected at each occurrence from the group: aryl substituted with 0-3 R 52 , and heterocycle substituted with 0-3 R 5 2 ; R 41 is independently selected from the group: H, aryl substituted with 0-1 R 52 , C1-C3 alkyl substituted with 0-1 R 52 , and a heterocycle substituted with 0- 1 R 52 ; R 52 is independently selected at each occurrence from the group: a bond to L n , -CO2R 53 , -CH2OR 53 , -SO3H, -S02R 53a , -N(R 53 )2, -N(R 53 )3 + , -NHC (=NH) NHR 53 , and -OCH2CO2H; R 53 and R^3a are each independently selected at each occurrence from the group: H and C3 . -C3 alkyl; ALI is a functionalized aminocarboxylate; 2 i an ancillary ligand of formula: R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 ^ is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , or - CO2R 71 , and C3.-6 alkyl substituted with 1-5 -OR 71 . [25] In another embodiment, the present invention provides a radiopharmaceutical embodiment 23 wherein: Q is a biomolecule selected from the group: Ilb/IIIa receptor antagonists and chemotactic peptides; d' is 1; Y 1 and Y 2 , at each occurrence, are independently selected from: 0, NR 56 , C=0, C(=0)0, 0C(=0)0, C(=0)NH, C=NR 5β , NHC(=0), and (NH) 2C (=0) ; R 55 and R 56 are H; z is 1; R ^ is a heterocycle substituted with R52 ; R 41 is H; R 52 is a bond to L n ; AL → l is tricine; AL2 is an ancillary ligand of formula: ; R 67 is C(0)NR 68 R 69 ; R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R ( ^ and is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , - CO2R 71 and Ci-10 alkyl substituted with 1-5 -OR 71 . [26] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 23, wherein: AL2 is an ancillary ligand of formula : R 67 is C (0) NR 68 R 69 ; R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-6 alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-.5 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 70 is -OR 71 , -S03R 71a , -CO2R 71 . [27] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 23, wherein: AL2 is an ancillary ligand of formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-6 alkyl substituted with 1-5 R 70 and 0-2 R 70a ; R^ is hydrogen; R 70 is -OR 71 , -S03R 71a , -CO2R 71 ; R 71 is H; and R 71a i s independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 1-5 hydroxyl substituents. [28] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 23, wherein: AL2 is ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-3 alkyl substituted with 1-3 R 70 ; R^9 is hydrogen; R 70 is -OR 71 , -S03R 71 , or -CO2R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl substituted with 1-2 hydroxyl substituents. [29] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 23, wherein: AL2 i ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is C1-2 alkyl substituted with 1-2 R 70 R 9 is hydrogen; R 70 is -OR 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl substituted with 1-2 hydroxyl substituents. [30] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 23, wherein: Aχ-2 is ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-3 alkyl substituted with 1-3 R 70 ; R69 is hydrogen; R 70 is -Sθ3R 71 or -CO2R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Cχ-2 alkyl. [31] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 23, wherein: AL2 is ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R68 Cl __ 3 a ikyi substituted with 1-3 R 70 and 0-3 R 70a ; R69 i s hydrogen; R 70 is -CO2R 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and C1-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Ci-Cβ alkyl substituted with 0-5 hydroxyl substituents. [32] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 23, wherein: AL2 is ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R^ is independently selected, at each occurrence, from the group consisting of: tetrohydropyranyl substituted with 1-4 R 7 0 and 0-1 R 7 ^ 9 -, and tetrohydrofuranyl substituted with 1-3 R 70 and 0-1 R 71a ; R6 is hydrogen; R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , and C]_ alkyl substituted with 1 -OR 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Cι_2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Ci-C δ alkyl substituted with 0-5 hydroxyl substituents. [33] In another embodiment, the present invention provides a radiopharmaceutical according to embodiment 23, wherein: AL2 is selected from the group: ; or pharmaceutically acceptable salts thereof. [34] In another embodiment, the present invention provides a radiopharmaceutical of embodiment 23 wherein: Q is d' is 1; L n is attached to Q at the carbon atom designated with a * and has the formula: - (C=0)NH (CH2) 5C (=0)NH- ; C ' is , and is attached to L n at the carbon atom designated with a Mt is 99m Tc; and ALI is tricine. [35] In another embodiment, the present invention provides a radiopharmaceutical according to any one of embodiments 23-34 wherein the Q-Ln moiety is selected from the group : , wherein * indicates the point of attachment to the chelator moiety (Ch) . [36] In another embodiment, the present invention provides a radiopharmaceutical according to any one of embodiment 23-34, wherein the radiopharmaceutical is selected from the group: -63- a pharmaceutically acceptable salt form thereof. [37] In another embodiment, the present invention provides a method for radioimaging a patient comprising: (i) administering to said patient an effective amount of a radiopharmaceutical according to any one of embodiment 23-36; and (ii) scanning the patient using a radioimaging device. [38] In another embodiment, the present invention provides a method for visualizing sites of platelet deposition in a patient by radioimaging, comprising: (i) administering to said patient an effective amount of a radiopharmaceutical according to any one of embodiment 23-36; and (ϋ) scanning the patient using a radioimaging device; wherein Q is a Ilb/IIIa receptor ligand or fibrin binding peptide. [39] In another embodiment, the present invention provides a method of determining platelet deposition in a patient comprising: (i) administering to said patient a radiopharmaceutical according to any one of embodiment 23-36; and (ii) imaging said patient; wherein Q is a Ilb/IIIa receptor ligand or fibrin binding peptide. [40] In another embodiment, the present invention provides a method of diagnosing a disorder associated with platelet deposition in a patient comprising: (i) administering to said patient a radiopharmaceutical composition according to any one of embodiment 23-36; and (ii) imaging said patient; wherein Q is a Ilb/IIIa receptor ligand or fibrin binding peptide. [41] In another embodiment, the present invention provides a method of diagnosing thromboembolic disorders or atherosclerosis in a patient, comprising: (i) administering to said patient a radiopharmaceutical according to any one of embodiment 23-36; and (ii) generating a radioimage of at least a part of said patient's body; wherein Q is a Ilb/IIIa receptor ligand or fibrin binding peptide. [42] In another embodiment, the present invention provides a method of diagnosing infection, inflammation or transplant rejection in a patient, comprising: (i) administering to said patient a radiopharmaceutical according to any one of embodiment 23-36; and (ii) generating a radioimage of at least a part of said patient's body; wherein Q is selected from the group consisting of a leukocyte binding peptide, a chemotactic peptide, and a LTB receptor antagonist. [43] In another embodiment, the present invention provides a method of detecting new angiogenic vasculature in a patient, comprising: (i) administering to said patient a radiopharmaceutical according to any one of embodiment 23-36; and (ii) generating a radioimage of at least a part of said patient's body; wherein Q is a vitronectin receptor antagonist, a somatostatin analog, or a growth factor receptor antagonist. [44] In another embodiment, the present invention provides a kit for forming a radiopharmaceutical complex comprising the following components: (i) an ancillary ligand according to any one of embodiment 1-11; (ϋ) optionally a reducing agent; and (iii) instructions for reacting the components of said kit with a radionuclide solution. [45] In another embodiment, the present invention provides a kit for preparing a radiopharmaceutical comprising: (a) a predetermined quantity of a sterile, pharmaceutically acceptable first ancillary ligand, AL2 , according to any one of embodiment 1-11; (b) a predetermined quantity of a sterile, pharmaceutically acceptable reagent of formula: ( Q)d'Ln-Ch; (c) a predetermined quantity of a sterile, pharmaceutically acceptable second ancillary ligand, Ατ_,l. selected from the group: a dioxygen ligand and a functionalized aminocarboxylate; (d) a predetermined quantity of a sterile, pharmaceutically acceptable reducing agent; and (e) optionally, a predetermined quantity of one or more sterile, pharmaceutically acceptable components selected from the group: transfer ligands, buffers, lyophilization aids, stabilization aids, solubilization aids and bacteriostats; wherein : Q is a biomolecule; d' is 1 to 20; n is a linking group of formula: M 1 - [Y 1 (CR 55 R 56 ) f (Z 1 ) f i«Y ] f * -M 2 , M 1 is -[(CH2)gZ 1 ]g'-(CR 55 R 56 ) g »-; M 2 is -(CR 55 R 56 )g"-[Z 1 (CH2)g]g'-; g is independently 0-10; g' is independently 0-1; g" is independently 0-10; f is independently 0-10; f is independently 0-10; f" is independently 0-1; γl and Y 2 , at each occurrence, are independently selected from: a bond, 0, NR 56 , C=0, C(=0)0, 0C(=0)0, C(=0)NH-, C=NR 56 , S, SO, S02 , SO3 , NHC(=0), (NH)2C(=0), and (NH)2C=S; Z-L is independently selected at each occurrence from a C6-C14 saturated, partially saturated, or aromatic carbocyclic ring system, substituted with 0-4 R57; and a heterocyclic ring system, optionally substituted with 0-4 R 57 ; R55 an ci R56 are independently selected at each occurrence from: H, C1-C10 alkyl substituted with 0-5 R°A and alkaryl wherein the aryl is substituted with 0-5 R57; R57 is independently selected at each occurrence from the group: H, OH, NHR 58 , C(=0)R 58 , OC(=0)R 58 , 0C(=0)0R 58 , C(=0)OR 58 , C(=0)NR 58 , -CN, SR 58 , SOR 58 , S02R 58 , NHC(=0)R 58 , NHC(=0)NHR 58 , and NHC (=S)NHR 58 , alternatively, when attached to an additional molecule Q, R57 is independently selected at each occurrence from the group: 0, NR 58 , C=0, C(=0)0, OC(=0)0, C(=0)N, C=NR 58 , S, SO, SO2 , SO3 , NHC(=0), (NH)2C(=0), and (NH)2C=S; R5 8 is independently selected at each occurrence from the group: H, Ci-Cg alkyl, benzyl, and phenyl; x, y and z are independently 1 or 2; Mt is a transition metal radionuclide selected from the group: 9 9 m c, 18β Re and 188 Re; C ' is a radionuclide metal chelator coordinated to transition metal radionuclide M , and is independently selected at each occurrence, from the group: R 0 N=N + =, R 0 R 1 N-N=, and R 0 N=N(H) -; R 4 ^ is independently selected at each occurrence from the group: a bond to n , Ci-Cio alkyl substituted with 0-3 R 52 , aryl substituted with 0-3 R 52 , cycloaklyl substituted with 0-3 R 52 , heterocycle substituted with 0-3 R 52 heterocycloalkyl substituted with 0-3 R 52 , aralkyl substituted with 0-3 R 52 and alkaryl substituted with 0-3 R 52 ; R 1 is independently selected from the group: H, aryl substituted with 0-3 R 52 , Ci-Cio alkyl substituted with 0-3 R 52 , and a heterocycle substituted with 0- 3 R5 2 ; R 52 is independently selected at each occurrence from the group: a bond to L n . =0, F, Cl, Br, I, -CF3 , - CN, -C02R 53 , -C(=0)R 53 , -C(=0)N(R 53 )2. -CHO, -CH2OR 53 , -0C(=0)R 53 , -OC(=0)OR 53a , -OR 53 , -OC(=0)N(R 53 )2, -NR 53 C(=0)R 53 , -N(R 53 )3 + , -NR 54 C(=0)OR 53a , -NR 53 C(=0)N(R 53 )2, -NR 54 S02N(R 53 )2, -NR 5 Sθ2R 53a , -SO3H, -Sθ2R 53a , -SR 53 , -S(=0)R 53a , -S02N(R 53 )2, -N(R 53 )2, -NHC(=NH)NHR 53 , -C (=NH) HR 53 , =N0R 53 , 02 , -C(=0)NHOR 53 , -C(=0)NHNR 53 R 53a , -OCH2CO2H, and 2- (1-morpholino) ethoxy; and R 53 , R53a anc j p54 are eacn independently selected at each occurrence from the group: H, C1-C6 alkyl, and a bond to L n . [46] In another embodiment, the present invention provides a kit according to embodiment 45, wherein the Q-Ln moiety is selected from the group: -79- , wherein * indicates the point of attachment to the chelator moiety (Ch) . [47] In another embodiment, the present invention provides a diagnostic composition comprising a diagnostic effective amount of the radiopharmaceutical according to any one of embodiments 23-36 and a pharmaceutically acceptable carrier. It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention which are for brevity, described in the context of a single embodiment, may also be provided separately or in any subcombination. DEFINITIONS As used herein, "diagnostic effective amount" is meant to describe an amount of composition according to the present invention effective in producing the desired diagnostic effect. As used herein, "alkyl" is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms. Examples of alkyl include, but are not limited to, methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, t-butyl, n-pentyl, and s-pentyl. "Haloalkyl" is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms, substituted with 1 or more halogen (for example -C V F W where v = 1 to 3 and w = 1 to (2v+l) ) . Examples of haloalkyl include, but are not limited to, trifluoromethyl, trichloromethyl, pentafluoroethyl, and pentachloroethyl . As used herein, "alkoxy" represents an alkyl group as defined above with the indicated number of carbon atoms attached through an oxygen bridge. Examples of alkoxy include, but are not limited to, methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy, s-butoxy, t-butoxy, n-pentoxy, and s-pentoxy. As used herein, "alkenyl" is intended to include hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon-carbon bonds which may occur in any stable point along the chain, such as ethenyl and propenyl . As used herein, "alkynyl" is intended to include hydrocarbon chains of either a straight or branched configuration and one or more triple carbon-carbon bonds which may occur in any stable point along the chain, such as ethynyl and propynyl . "Halo" or "halogen" as used herein refers to fluoro, chloro, bromo, and iodo; and "counterion" is used to represent a small, negatively charged species such as chloride, bromide, hydroxide, acetate, and sulfate. The term "carbocycle" or "carbocyclic residue" as used herein, is intended to mean any stable 3- to 7- membered monocyclic or bicyclic or 7-to 13-membered bicyclic or tricyclic, any of which may be saturated (i.e. a cycloalkyl moiety), partially unsaturated saturated (i.e. a cycloalkenyl moiety), or aromatic (i.e. an aryl moiety). Examples of such carbocycles include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, cyclooctyl, [3.3.0]bicyclooctane, [4.3.0]bicyclononane, [4.4. O]bicyclodecane, [2.2.2]bicyclooctane, fluorenyl, phenyl, naphthyl, indanyl, adamantyl, and tetrahydronaphthyl . The term "cycloalkyl" as used herein, means a nonaromatic mono- or ulticyclic ring system of about 3 to about 10 carbon atoms, preferably of about 5 to about 10 carbon atoms. Preferred ring sizes of rings of the ring system include about 5 to about 6 ring atoms . Exemplary monocyclic cycloalkyl include cyclopentyl, cyclohexyl, cycloheptyl, and the like. Exemplary multicyclic cycloalkyl include 1-decalin, norbornyl, adamant- (1- or 2-)yl, and the like. The term "cycloalkenyl" as used herein, means a non-aromatic mono- or multicyclic ring system of about 3 to about 10 carbon atoms, preferably of about 5 to about 10 carbon atoms, and which contains at least one carbon- carbon double bond. Preferred ring sizes of rings of the ring system include about 5 to about 6 ring atoms. Exemplary monocyclic cycloalkenyl include cyclopentenyl, cyclohexenyl, cycloheptenyl, and the like. An exemplary multicyclic cycloalkenyl is norbornylenyl . The term "aryl" as used herein, means an aromatic monocyclic or multicyclic ring system of about 6 to about 14 carbon atoms, preferably of about 6 to about 10 carbon atom . Exemplary aryl groups include phenyl or naphthyl, or phenyl substituted or naphthyl substituted. The term "heterocycle" or "heterocyclic system" as used herein, is intended to mean a stable 5-to 7- membered monocyclic or bicyclic or 7-to 10-membered bicyclic heterocyclic ring which is a saturated heterocyclic ring (i.e. a heterocyclyl moiety), a partially unsaturated heterocyclic ring (i.e. a heterocyclenyl moiety) , or an unsaturated heterocyclic ring (i.e. a heteroaryl moiety), and which consists of carbon atoms and from 1 to 4 heteroatoms independently selected from the group consisting of N, 0 and S and including any bicyclic group in which any of the above- defined heterocyclic rings is fused to a benzene ring. The nitrogen and sulfur heteroatoms may optionally be oxidized. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings 55- described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. A nitrogen in the heterocycle may optionally be quaternized. It is preferred that when the total number of S and 0 atoms in the heterocycle exceeds 1, then these heteroatoms are not adjacent to one another. It is preferred that the total number of S and 0 atoms in the heterocycle is not more than 1. Examples of heterocycles include, but are not limited to, acridinyl, azocinyl, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, benzimidazolinyl, carbazolyl, 4aff-carbazolyl, carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydroquinolinyl, 2H, 6H-1 , 5, 2-dithiazinyl, dihydrofuro [2, 3 -b] tetrahydrofuran, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imidazolyl, liϊ-indazolyl, indolenyl, indolinyl, indolizinyl, indolyl, 3H-indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl, isothiazolyl, isoxazolyl, methylenedioxyphenyl, morpholinyl, naphthyridinyl, octahydroisoquinolinyl, oxadiazolyl, 1, 2 , 3-oxadiazolyl, 1, 2 , 4-oxadiazolyl , 1, 2 , 5-oxadiazolyl, 1, 3 , 4-oxadiazolyl, oxazolidinyl, oxazolyl, oxazolidinyl, pyrimidinyl, phenanthridinyl , phenanthrolinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, piperazinyl, piperidinyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazole, pyridoimidazole, pyridothiazole, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolinyl, 2H-pyrrolyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, tetrahydrofuranyl, tetrahydroisoquinolinyl, tetrahydroquinolinyl, 6iJ-l,2,5- thiadiazinyl, 1, 2 , 3-thiadiazolyl, 1, 2 , 4-thiadiazolyl, 1, 2 , 5-thiadiazolyl, 1, 3 , 4-thiadiazolyl, thianthrenyl , thiazolyl, thienyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thiophenyl, triazinyl, 1,2,3- triazolyl, 1, 2 , 4-triazolyl, 1, 2 , 5-triazolyl, 1,3,4- triazolyl, and xanthenyl . Preferred heterocycles include, but are not limited to, pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, pyrrolidinyl, imidazolyl, indolyl, benzimidazolyl, lH-indazolyl, oxazolidinyl, benzotriazolyl, benzisoxazolyl, oxindolyl, benzoxazolinyl, and isatinoyl. Also included are fused ring and spiro compounds containing, for example, the above heterocycles. The term "aromatic heterocyclic system" or "heteroaryl" as used herein, means an aromatic monocyclic or multicyclic ring system of about 5 to about 14 carbon atoms, preferably about 5 to about 10 carbon atoms, in which one or more of the carbon atoms in the ring system is/are hetero element (s) other than carbon, for example nitrogen, oxygen or sulfur. Preferred ring sizes of rings of the ring system include about 5 to about 6 ring atoms . The designation of the aza, oxa or thia as a prefix before heteroaryl define that at least a nitrogen, oxygen or sulfur atom is present respectively as a ring atom. It is preferred that the total number of S and 0 atoms in the aromatic heterocycle is not more than 1. A nitrogen atom of an heteroaryl may be a basic nitrogen atom and may also be optionally oxidized to the corresponding N-oxide. Heteroaryl as used herein includes by way of example and not limitation those described in Paquette, Leo A. ; "Principles of Modern Heterocyclic Chemistry" (W. A. Benjamin, New York, 1968), particularly Chapters 1, 3, 4, 6, 7, and 9; "The Chemistry of Heterocyclic Compounds, A series of Monographs" (John Wiley & Sons, New York, 1950 to present), in particular Volumes 13, 14, 16, 19, and 28; and "J. Am. Chem. Soc. ", 82:5566 (1960) . Exemplary heteroaryl and substituted heteroaryl groups include pyrazinyl, thienyl, isothiazolyl, oxazolyl, pyrazolyl, furazanyl, pyrrolyl, 1,2,4- thiadiazolyl, pyridazinyl, quinoxalinyl, phthalazinyl, imidazo [1, 2-a]pyridine, i idazo [2 , 1-b] thiazolyl, benzofurazanyl, azaindolyl, benzimidazolyl, benzothienyl, thienopyridyl, thienopyrimidyl, pyrrolopyridyl, imidazopyridyl, benzoazaindole, 1, 2 , 4-triazinyl, benzthiazolyl, furanyl, imidazolyl, indolyl, indolizinyl, isoxazolyl, isoquinolinyl, isothiazolyl, oxadiazolyl, pyrazinyl, pyridazinyl, pyrazolyl, pyridyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolinyl, 1, 3 , 4-thiadiazolyl, thiazolyl, thienyl and triazolyl. The term "heterocyclenyl" as used herein, means a non-aromatic monocyclic or multicyclic hydrocarbon ring system of about 3 to about 10 carbon atoms, preferably about 5 to about 10 carbon atoms, in which one or more of the carbon atoms in the ring system is/are hetero element (s) other than carbon, for example nitrogen, oxygen or sulfur atoms, and which contains at least one carbon-carbon double bond or carbon-nitrogen double bond. It is preferred that the total number of S and 0 atoms in the heterocyclenyl is not more than 1. Preferred ring sizes of rings of the ring system include about 5 to about 6 ring atoms . The designation of the aza, oxa or thia as a prefix before heterocyclenyl define that at least a nitrogen, oxygen or sulfur atom is present respectively as a ring atom. The nitrogen atom of an heterocyclenyl may be a basic nitrogen atom. The nitrogen or sulphur atom of the heterocyclenyl may also be optionally oxidized to the corresponding N-oxide, S-oxide or S,S-dioxide. "Heterocyclenyl" as used herein includes by way of example and not limitation those described in Paquette, Leo A. ; "Principles of Modern Heterocyclic Chemistry" (W. A. Benjamin, New York, 1968), particularly Chapters 1, 3, 4, 6, 7, and 9; "The Chemistry of Heterocyclic Compounds, A series of Monographs" (John Wiley & Sons, New York, 1950 to present), in particular Volumes 13, 14, 16, 19, and 28; and "J. Am. Chem. Soc . ", 82:5566 (1960) . Exemplary monocyclic azaheterocyclenyl groups include 1,2,3,4- tetrahydrohydropyridine, 1 , 2-dihydropyridyl , 1 , 4-dihydropyridyl , 1,2,3, 6-tetrahydropyridine, 1,4,5,6- tetrahydropyrimidine, 2-pyrrolinyl, 3-pyrrolinyl, 2- imidazolinyl, 2-pyrazolinyl, and the like. Exemplary oxaheterocyclenyl groups include 3 , 4-dihydro-2H-pyran, dihydrofuranyl, and fluorodihydrofuranyl . Preferred is dihydrofuranyl . An exemplary multicyclic oxaheterocyclenyl group is 7-oxabicyclo [2.2. l]heptenyl . Preferred monocyclic thiaheterocycleny rings include dihydrothiophenyl and dihydrothiopyranyl; more preferred is dihydrothiophenyl . The term "heterocyclyl" as used herein, means a non-aromatic saturated monocyclic or multicyclic ring system of about 3 to about 10 carbon atoms, preferably about 5 to about 10 carbon atoms, in which one or more of the carbon atoms in the ring system is/are hetero element (s) other than carbon, for example nitrogen, oxygen or sulfur. It is preferred that the total number of S and 0 atoms in the aromatic heterocycle is not more than 1. Preferred ring sizes of rings of the ring system include about 5 to about 6 ring atoms. The designation of the aza, oxa or thia as a prefix before heterocyclyl define that at least a nitrogen, oxygen or sulfur atom is present respectively as a ring atom. The nitrogen atom of an heterocyclyl may be a basic nitrogen atom. The nitrogen or sulphur atom of the heterocyclyl may also be optionally oxidized to the corresponding N-oxide, S-oxide or S,S-dioxide. "Heterocyclyl" as used herein includes by way of example and not limitation those described in Paquette, Leo A. ; "Principles of Modern Heterocyclic Chemistry" (W. A. Benjamin, New York, 1968), particularly Chapters 1, 3, 4, 6, 7, and 9; "The Chemistry of Heterocyclic Compounds, A series of Monographs" (John Wiley & Sons, New York, 1950 to present), in particular Volumes 13, 14, 16, 19, and 28; and "J. Am. Chem. Soc . ", 82:5566 (1960). Exemplary monocyclic heterocyclyl rings include piperidyl, pyrrolidinyl, piperazinyl, morpholinyl, thiomorpholinyl, t iazolidinyl, 1, 3-dioxolanyl, 1, 4-dioxanyl, tetrahydrofuranyl , tetrahydropyranyl , tetrahydrothiophenyl, tetrahydrothiopyranyl, and the like. The term "amino acid" as used herein means an organic compound containing both a basic amino group and an acidic carboxyl group. Included within this term are natural amino acids (e.g., L-amino acids), modified and unusual amino acids (e.g., D-amino acids), as well as amino acids which are known to occur biologically in free or combined form but usually do not occur in proteins. Included within this term are modified and unusual amino acids, such as those disclosed in, for example, Roberts and Vellaccio (1983) The Peptides, 5: 342-429, the teaching of which is hereby incorporated by reference. Natural protein occurring amino acids include, but are not limited to, alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tyrosine, tyrosine, tryptophan, proline, and valine. Natural non-protein amino acids include, but are not limited to arginosuccinic acid, citrulline, cysteine sulfinic acid, 3 , 4-dihydroxyphenylalanine, homocysteine, homoserine, ornithine, 3-monoiodotyrosine, 3 , 5-diiodotryosine, 3 , 5, 5 ' -triiodothyronine, and 3 , 3 ' , 5, 5 ' -tetraiodothyronine . Modified or unusual amino acids which can be used to practice the invention include, but are not limited to, D-amino acids, hydroxylysine, 4-hydroxyproline, an N-Cbz-protected amino acid, 2 , 4-diaminobutyric acid, homoarginine, norleucine, N-methylaminobutyric acid, naphthylalanine, phenylglycine, β-phenylproline, tert-leucine, 4-aminocyclohexylalanine, N-methyl-norleucine, 3 , 4-dehydroproline, N,N-dimethylaminoglycine, N-methylaminoglycine, 4-aminopiperidine-4-carboxylic acid, 6-aminocaproic acid, trans-4- (aminomethyl) -cyclohexanecarboxylic acid, 2-, 3-, and 4- (aminomethyl) -benzoic acid, 1-aminocyclopentanecarboxylic acid, 1-aminocyclopropanecarboxylic acid, and 2-benzyl-5-aminopentanoic acid. The term "peptide" as used herein means a linear compound that consists of two or more amino acids (as defined herein) that are linked by means of a peptide bond. A "peptide" as used in the presently claimed invention is intended to refer to a moiety with a molecular weight of less than 10,000 Daltons, preferable less than 5,000 Daltons, and more preferably less than 2,500 Daltons. The term "peptide" also includes compounds containing both peptide and non-peptide components, such as pseudopeptide or peptidomimetic residues or other non-amino acid components. Such a compound containing both peptide and non-peptide components may also be referred to as a "peptide analog" . A "pseudopeptide" or "peptidomimetic" is a compound which mimics the structure of an amino acid residue or a peptide, for example, by using linking groups other than amide linkages between the peptide mimetic and an amino acid residue (pseudopeptide bonds) and/or by using non-amino acid substituents and/or a modified amino acid residue. A "pseudopeptide residue" means that portion of an pseudopeptide or peptidomimetic that is present in a peptide. The term "peptide bond" means a covalent amide linkage formed by loss of a molecule of water between the carboxyl group of one amino acid and the amino group of a second amino acid. The term "pseudopeptide bonds" includes peptide bond isosteres which may be used in place of or as substitutes for the normal amide linkage. These substitute or amide "equivalent" linkages are formed from combinations of atoms not normally found in peptides or proteins which mimic the spatial requirements of the amide bond and which should stabilize the molecule to enzymatic degradation. The phrase "pharmaceutically acceptable" is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio. As used herein, "pharmaceutically acceptable salts" refer to derivatives of the disclosed compounds wherein the parent compound is modified by making acid or base salts thereof. Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; and alkali or organic salts of acidic residues such as carboxylic acids. The pharmaceutically acceptable salts include the conventional non-toxic salts or the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids. For example, such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, and nitric; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, and isethionic. The pharmaceutically acceptable salts of the present invention can be synthesized from the parent compound which contains a basic or acidic moiety by conventional chemical methods. Generally, such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichio etric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in Remington 's Pharmaceutical Sciences, 17th ed., Mack Publishing Company, Easton, PA, 1985, p. 1418, the disclosure of which is hereby incorporated by reference. The term "pharmaceutically acceptable prodrugs" as used herein means those prodrugs of the compounds useful according to the present invention which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals with undue toxicity, irritation, allergic response, and the like, commensurate with a reasonable benefit/risk ratio, and effective for their intended use, as well as the zwitterionic forms, where possible, of the compounds of the invention. The term "prodrug" means compounds that are rapidly transformed in vivo to yield the parent compound of the above formula, for example by hydrolysis in blood. Functional groups which may be rapidly transformed, by metabolic cleavage, in vivo form a class of groups reactive with the carboxyl group of the compounds of this invention. They include, but are not limited to such groups as alkanoyl (such as acetyl, propionyl, butyryl, and the like) , unsubstituted and substituted aroyl (such as benzoyl and substituted benzoyl) , alkoxycarbonyl (such as ethoxycarbonyl) , trialkylsilyl (such as trimethyl- and triethysilyl) , monoesters formed with dicarboxylic acids (such as succinyl) , and the like. Because of the ease with which the metabolically cleavable groups of the compounds useful according to this invention are cleaved in vivo, the compounds bearing such groups act as pro-drugs . The compounds bearing the metabolically cleavable groups have the advantage that they may exhibit improved bioavailability as a result of enhanced solubility and/or rate of absorption conferred upon the parent compound by virtue of the presence of the metabolically cleavable group. Prodrugs include compounds of the present invention wherein a hydroxy, amino, or sulfhydryl group is bonded to any group that, when the prodrug of the present invention j.s administered to a mammalian subject, it cleaves to form a free hydroxyl, free amino, or free sulfhydryl group, respectively. Examples of prodrugs include, but are not limited to, acetate, formate and benzoate derivatives of alcohol and amine functional groups in the compounds of the present invention. A thorough discussion of prodrugs is provided in the following: Design of Prodrugs, H. Bundgaard, ed. , Elsevier, 1985; Methods in Enzymology, K. Widder et al, Ed., Academic Press, 42, p.309-396, 1985; A Textbook of Drug Design and Development, Krogsgaard-Larsen and H. Bundgaard, ed. , Chapter 5; "Design and Applications of Prodrugs" p.113-191, 1991; Advanced Drug Delivery Reviews, H. Bundgard, 8, p.1-38, 1992; Journal of Pharmaceutical Sciences, 77, p. 285, 1988; Chem. Pharm. Bull., N. Nakeya et al, 32, p. 692, 1984; Pro-drugs as Novel Delivery Systems, T. Higuchi and V. Stella, Vol. 14 of the A.C.S. Symposium Series, and Bioreversible Carriers in Drug Design, Edward B. Roche, ed. , American Pharmaceutical Association and Pergamon Press, 1987, which are incorporated herein by reference. "Stable compound" and "stable structure" are meant to indicate a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic or diagnostic agent. The biologically active molecule Q can be a protein, antibody, antibody fragment, peptide or polypeptide, or peptidomimetic that is comprised of a recognition sequence or unit for a receptor or binding site expressed at the site of the disease, or for a receptor or binding site expressed on platelets or leukocytes. The exact chemical composition of Q is selected based on the disease state to be diagnosed, the mechanism of localization to be utilized, and to provide an optimal combination of rates of localization, clearance and radio-decay. For the purposes of this invention, the term thromboembolic disease is taken to include both venous and arterial disorders and pulmonary embolism, resulting from the formation of blood clots. For the diagnosis of thromboembolic disorders or atherosclerosis, Q is selected from the group including the cyclic Ilb/IIIa receptor antagonist compounds described in co-pending U.S. Ser. No .08/218, 861 (equivalent to WO 94/22494) ; the RGD containing peptides described in U.S. Patents 4,578,079, 4,792,525, the applications PCT US88/04403, PCT US89/01742, PCT US90/03788, PCT US91/02356 and by 0j ima et . al . , 204th Meeting of the Amer. Chem. Soc . , 1992, Abstract 44; the peptides that are fibrinogen receptor antagonists described in European Patent Applications 90202015.5, 90202030.4, 90202032.2, 90202032.0, 90311148.2, 90311151.6, 90311537.6, the specific binding peptides and polypeptides described as Ilb/IIIa receptor ligands, ligands for the polymerization site of fibrin, laminin derivatives, ligands for fibrinogen, or thrombin ligands in PCT WO 93/23085 (excluding the technetium binding groups) ; the oligopeptides that correspond to the Ilia protein described in PCT WO90/00178; the hirudin-based peptides described in PCT WO90/03391; the lib/Ilia receptor ligands described in PCT WO90/15818; the thrombus, platelet binding or atherosclerotic plaque binding peptides described in PCT W092/13572 (excluding the technetium binding group) or GB 9313965.7; the fibrin binding peptides described in U.S. Patents 4,427,646 and 5,270,030; the hirudin-based peptides described in U.S. Patent 5,279,812; or the fibrin binding proteins described in U.S. Patent 5,217,705; the guanine derivatives that bind to the Ilb/IIIa receptor described in U.S. Patent 5,086,069; or the tyrosine derivatives described in European Patent Application 0478328A1, and by Hartman et. al . , J. Med. Chem., 1992, 35, 4640; or oxidized low density lipoprotein (LDL) . For the diagnosis of infection, inflammation or transplant rejection, Q is selected from the group including the leukocyte binding peptides described in PCT W093/17719 (excluding the technetium binding group) , PCT W092/13572 (excluding the technetium binding group) or U.S. Ser. No. 08/140000; the chemotactic peptides described in Eur. Pat. Appl. 90108734.6 or A. Fischman et. al., Semin. Nuc . Med., 1994, 24, 154; or the leukostimulatory agents described in U.S. Patent 5,277,892. For the diagnosis of cancer, Q is selected from the group of somatostatin analogs described in UK Application 8927255.3 or PCT WO94/00489, the selectin binding peptides described in PCT WO94/05269, the biological-function domains described in PCT W093/12819, Platelet Factor 4 or the growth factors (PDGF, EGF, FGF, TNF, MCSF or 11-8) . Q may also represent proteins, antibodies, antibody fragments, peptides, polypeptides, or peptidomimetics that bind to receptors or binding sites on other tissues, organs, enzymes or fluids. Examples include the β-amyloid proteins that have been demonstrated to accumulate in patients with Alzheimer's disease, atrial naturetic factor derived peptides that bind to myocardial and renal receptors, antimyosin antibodies that bind to areas of infarcted tissues, or nitroimidazole derivatives that localize in hypoxic areas in vivo. The group Ch' is termed a hydrazido (of formula R 0 R 1 N-N=) , or diazenido (formula R 0 N=N + = or R ( - ) N=N(H) -) group and serves as the point of attachment of the radionuclide to the remainder of the radiopharmaceutical designated by the formula (Q)d'~ L n or (Q)d' • A diazenido group can be either terminal (only one atom of the group is bound to the radionuclide) or chelating. In order to have a chelating diazenido group at least one other atom of the group, located on R 0, must also be bound to the radionuclide. The atoms bound to the metal are termed donor atoms . The transition metal radionuclide, Mt, is selected from the group: 99m Tc, 186 Re and 188 Re. For diagnostic purposes 99m Tc is the preferred isotope. Its 6 hour half-life and 140 keV gamma ray emission energy are almost ideal for gamma scintigraphy using equipment and procedures well established for those skilled in the art. The rhenium isotopes also have gamma ray emission energies that are compatible with gamma scintigraphy, however, they also emit high energy beta particles that are more damaging to living tissues. These beta particle emissions can be utilized for therapeutic purposes, for example, cancer radiotherapy. The coordination sphere of the radionuclide includes all the ligands or groups bound to the radionuclide. For a transition metal radionuclide, Mt, to be stable it typically has a coordination number (number of donor atoms) comprised of an integer greater than or equal to 4 and less than or equal to 8; that is there are 4 to 8 atoms bound to the metal and it is said to have a complete coordination sphere. The requisite coordination number for a stable radionuclide complex is determined by the identity of the radionuclide, its oxidation state, and the type of donor atoms. If the chelator or bonding unit Ch' does not provide all of the atoms necessary to stabilize the metal radionuclide by completing its coordination sphere, the coordination sphere is completed by donor atoms from other ligands, termed ancillary or coligands, which can also be either terminal or chelating. A large number of ligands can serve as ancillary or coligands, the choice of which is determined by a variety of considerations such as the ease of synthesis of the radiopharmaceutical, the chemical and physical properties of the ancillary ligand, the rate of formation, the yield, and the number of isomeric forms of the resulting radiopharmaceuticals, the ability to administer said ancillary or co-ligand to a patient without adverse physiological consequences to said patient, and the compatibility of the ligand in a lyophilized kit formulation. The charge and lipophilicity of the ancillary ligand will effect the charge and lipophilicity of the radiopharmaceuticals. For example, the use of 4 , 5-dihydroxy-l, 3-benzene disulfonate results in radiopharmaceuticals with an additional two anionic groups because the sulfonate groups will be anionic under physiological conditions. The use of N-alkyl substituted 3 , 4-hydroxypyridinones results in radiopharmaceuticals with varying degrees of lipophilicity depending on the size of the alkyl substituents . The radiopharmaceuticals of the present invention are comprised of two types of ancillary or coligands designated A I and A 2 • Ancillary ligands Aj_,ι are comprised of two or more hard donor atoms such as oxygen and amine nitrogen (sp 3 hydribidized) . The donor atoms occupy at least two of the sites in the coordination sphere of the radionuclide metal, Mt; the ancillary ligand ALI serves as one of the three ligands in the ternary ligand system. Examples of ancillary ligands ALI include but are not limited to dioxygen ligands and functionalized aminocarboxylates . A large number of such ligands are available from commercial sources . Ancillary dioxygen ligands include ligands that coordinate to the metal ion through at least two oxygen donor atoms. Examples include but are not limited to: glucoheptonate, gluconate, 2-hydroxyisobutyrate, lactate, tartrate, mannitol, glucarate, maltol, Kojic acid, 2, 2 -bis (hydroxymethyl )propionic acid, 4,5- dihydroxy-1, 3-benzene disulfonate, or substituted or unsubstituted 1,2 or 3,4 hydroxypyridinones . (The names for the ligands in these examples refer to either the protonated or non-protonated forms of the ligands.) Functionalized aminocarboxylates include ligands that have a combination of amine nitrogen and oxygen donor atoms. Examples include but are not limited to: iminodiacetic acid, 2, 3-diaminopropionic acid, nitrilotriacetic acid, N,N' -ethylenediamine diacetic acid, N,N,N' -ethylenediaminetriacetic acid, hydroxyethyl-ethylenediamine triacetic acid, and N,N'- ethylenediamine bis-hydroxyphenylglycine. (The names for the ligands in these examples refer to either the protonated or non-protonated forms of the ligands.) A series of functionalized aminocarboxylates are disclosed by Bridger et . al . in U.S. Patent 5,350,837, herein incorporated by reference, that result in improved rates of formation of technetium labeled hydrazino modified proteins. We have determined that certain of these aminocarboxylates result in improved yields of the radiopharmaceuticals of the present invention. The preferred ancillary ligands ALI functionalized aminocarboxylates that are derivatives of glycine; the most preferred is tricine (tris (hydroxymethyl)methyl-glycine) . The second type of ancillary ligands A 2 are highly functionalized phosphines. Ligands A 2 ar e monodentate. The ancillary ligands AL2 may be substituted with alkyl, aryl, alkoxy, heterocycle, aralkyl, alkaryl and arylalkaryl groups and may or may not bear functional groups comprised of heteroatoms such as oxygen, nitrogen, phosphorus or sulfur. Examples of such functional groups include but are not limited to: hydroxyl, carboxyl, carboxamide, nitro, ether, ketone, amino, ammonium, sulfonate, sulfonamide, phosphonate, and phosphonamide . The functional groups may be chosen to alter the lipophilicity and water solubility of the ligands, which may affect the biological properties of the radiopharmaceuticals, such as altering the distribution into non-target tissues, cells or fluids, and the mechanism and rate of elimination from the body. The radiopharmaceuticals of the present invention can be easily prepared by admixing a salt of a radionuclide, a reagent of Formula 2, an ancillary ligand ALI, an ancillary ligand A 2. and a reducing agent, in an aqueous solution at temperatures from room temperature to 100 °C. (Q)d'Ln-Ch (2) and pharmaceutically acceptable salts thereof, wherein: Q, d' , L n are as defined above, Ch is a radionuclide metal chelator selected from the group: R 4 ^R 1N-N=C (Cι~ C3 alkyl) 2 and R 40 NNH2-, and R 0 R 1 N-N=C (R 80 ) (R 81 ) , and pharmaceutically acceptable salts thereof. The synthesis of reagents of formula 2 is described in WO 94/22494 and in WO 96/40637. When C is a hydrazone group, then it must first be converted to the free hydrazine of formula R 4 0R 4 1NNH2, which may or may not be protonated, prior to complexation with the metal radionuclide, Mt . The chelator or bonding unit, Ch when bound to the metal radionuclide, Mt, is designated Ch' • The conversion of the hydrazone group to the hydrazine can occur either prior to reaction with the radionuclide, in which case the radionuclide and the ancillary or coligand or ligands are combined not with the reagent but with a hydrolyzed form of the reagent bearing the chelator or bonding unit, Ch, or in the presence of the radionuclide in which case the reagent itself is combined with the radionuclide and the ancillary or coligand or ligands. In the latter case, the pH of the reaction mixture must be neutral or acidic. Alternatively, the radiopharmaceuticals of the present invention can be prepared by first admixing a salt of a radionuclide, an ancillary ligand ALI, n ^ a reducing agent in an aqueous solution at temperatures from room temperature to 100 °C to form an intermediate radionuclide complex with the ancillary ligand A I then adding a reagent of Formula 2 and an ancillary ligand AL2 and reacting further at temperatures from room temperature to 100 °C . Alternatively, the radiopharmaceuticals of the present invention can be prepared by first admixing a salt of a radionuclide, an ancillary ligand ALI, a reagent of Formula 2, and a reducing agent in an aqueous solution at temperatures from room temperature to 100 °C to form an intermediate radionuclide complex, and then adding an ancillary ligand AL2 and reacting further at temperatures from room temperature to 100 °C. The total time of preparation will vary depending on the radionuclide, the identities and amounts of the reactants and the procedure used for the preparation. The preparations may be complete, resulting in > 80% yield of the radiopharmaceutical, in 1 minute or may require more time. If higher purity radiopharmaceuticals are needed or desired, the products can be purified by any of a number of techniques well known to those skilled in the art such as liquid chromatography, solid phase extraction, solvent extraction, dialysis or ultrafiltration. The technetium and rhenium radionuclides are preferably in the chemical form of pertechnetate or perrhenate and a pharmaceutically acceptable cation. The pertechnetate salt form is preferably sodium pertechnetate such as obtained from commercial Tc-99m generators. The amount of pertechnetate used to prepare the radiopharmaceuticals of the present invention can range from 0.1 mCi to 1 Ci, or more preferably from 1 to 200 mCi. The amount of the reagent of formula 2 used to prepare the radiopharmaceuticals of the present invention can range from 0.1 μg to 10 mg, or more preferably from 0.5 μg to 100 μg. The amount used will be dictated by the amounts of the other reactants and the identity of the radiopharmaceuticals of Formula 1 to be prepared. The amounts of the ancillary ligands ALI used can range from 0.1 mg to 1 g, or more preferrably from 1 mg to 100 mg. The exact amount for a particular radiopharmaceutical is a function of identity of the radiopharmaceuticals of Formula 1 to be prepared, the procedure used and the amounts and identities of the other reactants. Too large an amount of ALI will result in the formation of by-products comprised of technetium labeled A I without a biologically active molecule or by-products comprised ' of technetium labeled biologically active molecules with the ancillary ligand A I but without the ancillary ligand A 2 • T o small an amount of A I will result in other by-products such as technetium labeled biologically active molecules with the ancillary ligand AL2 but without the ancillary ligand ALI, °r reduced hydrolyzed technetium, or technetium colloid. The amounts of the ancillary ligands AL2 used can range from 1 mg to 1 g, or more preferrably from 1 mg to 10 mg. The exact amount for a particular radiopharmaceutical is a function of the identity of the radiopharmaceuticals of Formula 1 to be prepared, the procedure used and the aι.,-nts and identities of the other reactants. Too large an amount of AL2 will result in the formation of by-products comprised of technetium labeled A 2 without a biologically active molecule or by-products comprised of technetium labeled biologically active molecules with the ancillary ligand AL2 but without the ancillary ligand ALI . If the moiety (Q)d'~ L n~Ch' bears one or more substituents that are comprised of a soft donor atom, as defined above, at least a tenfold molar excess of the ancillary ligand AL2 to the reagent of formula 2 is required to prevent the substituent from interfering with the coordination of the ancillary ligand AL2 to the metal radionuclide, Mt . Suitable reducing agents for the synthesis of the radiopharmaceuticals of the present invention include stannous salts, dithionite or bisulfite salts, borohydride salts, and formamidinesulfinic acid, wherein the salts are of any pharmaceutically acceptable form. The preferred reducing agent is a stannous salt. The amount of a reducing agent used can range from 0.001 mg to 10 mg, or more preferably from 0.005 mg to 1 mg. The specific structure of a radiopharmaceutical of the present invention will depend on the identity of the biomolecule Q, the number d' , the identity of the linker L n , the identity of the chelator moiety Ch' , the identity of the ancillary ligand A I, the identity of the ancillary ligand AL2 and the identity of the radionuclide Mt- The identities of Q, L n , and Ch' and the number d' are determined by the choice of the reagent of Formulae 2 or 3. For a given reagent of Formulae 2 or 3 , the amount of the reagent, the amount and identity of the ancillary ligands ALI and AL2 , the identity of the radionuclide M and the synthesis conditions employed will determine the structure of the radiopharmaceutical of Formula 1. Radiopharmaceuticals synthesized using concentrations of reagents of Formulae 2 or 3 of <100 μg/mL, will be comprised of one hydrazido or diazenido group Ch' ; the value of x will be 1. Those synthesized using >1 mg/mL concentrations will be comprised of two hydrazido or diazenido groups; the value of x will be 2. The two Ch' groups may be the same or different. For most applications, only a limited amount of the biologically active molecule can be injected and not result in undesired side-effects, such as chemical toxicity, interference with a biological process or an altered biodistibution of the radiopharmaceutical. Therefore, the radiopharmaceuticals with x equal to 2, which require higher concentrations of the reagents of Formula 2 comprised in part of the biologically active molecule, will have to be diluted or purified after synthesis to avoid such side-effects. The identities and amounts used of the ancillary ligands A I and AL2 will determine the values of the variables y and z. The values of y and z can independently be an integer from 1 to 2. In combination, the values of y and z will result in a technetium coordination sphere that is made up of at least five and no more than seven donor atoms. For monodentate ancillary ligands A 2, Z ca be an integer from 1 to 2; for bidentate or tridentate ancillary ligands 2. z is 1. The preferred combination for monodentate ligands is y equal to 1 or 2 and z equal to 1. The preferred combination for bidentate or tridentate ligands is y equal to 1 and z equal to 1. Since prodrugs are known to enhance numerous desirable qualities of pharmaceuticals (e.g., solubility, bioavailability, manufacturing, etc..) the compounds of the present invention may be delivered in prodrug form. Thus, the present invention is intended to cover prodrugs of the presently claimed compounds, methods of delivering the same and compositions containing the same. Another aspect of the present invention are diagnostic kits for the preparation of radiopharmaceuticals useful as imaging agents for the diagnosis of cardiovascular disorders, infectious disease, inflammatory disease and cancer. Diagnostic kits of the present invention comprise one or more vials containing the sterile, non-pyrogenic, formulation comprised of a predetermined amount of the reagent of formulae (Q) £' -L n -Ch or (Q) ,3 -L n -H z , one or two ancillary or coligands and optionally other components such as reducing agents, transfer ligands, buffers, lyophilization aids, stabilization aids, solubilization aids and bacteriostats . The inclusion of one or more optional components in the formulation will frequently improve the ease of synthesis of the radiopharmaceutical by the practising end user, the ease of manufacturing the kit, the shelf-life of the kit, or the stability and shelf-life of the radiopharmaceutical. The improvement achieved by the inclusion of an optional component in the formulation must be weighed against the added complexity of the formulation and added cost to manufacture the kit. The one or more vials that contain all or part of the formulation can independently be in the form of a sterile solution or a lyophilized solid. Buffers useful in the preparation of radiopharmaceuticals and in diagnostic kits useful for the preparation of said radiopharmaceuticals include but are not limited to phosphate, citrate, sulfosalicylate, and acetate. A more complete list can be found in the United States Pharmacopeia. Lyophilization aids useful in the preparation of diagnostic kits useful for the preparation of radiopharmaceuticals include but are not limited to mannitol, lactose, sorbitol, dextran, Ficoll, and polyvinylpyrrolidine (PVP) . Stabilization aids useful in the preparation of radiopharmaceuticals and in diagnostic kits useful for the preparation of said radiopharmaceuticals include but are not limited to ascorbic acid, cysteine, monothioglycerol, sodium bisulfite, sodium metabisulfite, gentisic acid, and inositol. Solubilization aids useful in the preparation of radiopharmaceuticals and in diagnostic kits useful for the preparation of said radiopharmaceuticals include but are not limited to ethanol, glycerin, polyethylene glycol, propylene glycol, polyoxyethylene sorbitan monooleate, sorbitan monoloeate, polysorbates, poly (oxyethylene) -poly (oxypropylene) poly(oxyethylene) block copolymers (Pluronics) and lecithin. Preferred solubilizing aids are polyethylene glycol, and Pluronics . Bacteriostats useful in the preparation of radiopharmaceuticals and in diagnostic kits useful for • the preparation of said radiopharmaceuticals include but are not limited to benzyl alcohol, benzalkonium chloride, chlorbutanol, and methyl, propyl or butyl paraben . A component in a diagnostic kit can also serve more than one function. A reducing agent can also serve as a stabilization aid, a buffer can also serve as a transfer ligand, a lyophilization aid can also serve as a transfer, ancillary or coligand and so forth. The predetermined amounts of each component in the formulation are determined by a variety of considerations that are in some cases specific for that component and in other cases dependent on the amount of another component or the presence and amount of an optional component. In general, the minimal amount of each component is used that will give the desired effect of the formulation. The desired effect of the formulation is that the practising end user can synthesize the radiopharmaceutical and have a high degree of certainty that the radiopharmaceutical can be safely injected into a patient and will provide diagnostic information about the disease state of that patient. The diagnostic kits of the present invention will also contain written instructions for the practising end user to follow to synthesize the radiopharmaceuticals. These instructions may be affixed to one or more of the vials or to the container in which the vial or vials are packaged for shipping or may be a separate insert, termed the package insert . Another aspect of the present invention contemplates a method of imaging the site of thrombotic disease in a patient involving: (1) synthesizing a radiopharmaceutical using a reagent of the present ' invention capable of localizing at sites of thrombotic disease due to an interaction between the biologically active group, Q, of the radiopharmaceutical and a receptor or binding site expressed at the site of the disease or with a receptor or binding site on an endogenous blood component that accumulates at the site; (2) administering said radiopharmaceutical to a patient by injection or infusion; (3) imaging the patient using either planar or SPECT gamma scintigraphy. Another aspect of the present invention contemplates a method of imaging the site of infection or infectious disease in a patient involving: (1) synthesizing a radiopharmaceutical using a reagent of the present invention capable of localizing at sites of infection or infectious disease due to an interaction between the biologically active group, Q, of the radiopharmaceutical and a receptor or binding site expressed at the site of the disease or with a receptor or binding site on an endogenous blood component that accumulates at the site; (2) administering said radiopharmaceutical to a patient by injection or infusion; (3) imaging the patient using either planar or SPECT gamma scintigraphy. Another aspect of the present invention contemplates a method of imaging the site of inflammation in a patient involving: (1) synthesizing a radiopharmaceutical using a reagent of the present invention capable of localizing at sites of inflammation due to an interaction between the biologically active group, Q, of the radiopharmaceutical and a receptor or binding site expressed at the site of inflammation or with a receptor or binding site on an endogenous blood component that accumulates at the site; (2) administering said radiopharmaceutical to a patient by injection or infusion; (3) imaging the patient using either planar or SPECT gamma scintigraphy. Another aspect of the present invention contemplates a method of imaging the site of cancer in a patient involving: (1) synthesizing a radiopharmaceutical using a reagent of the present invention capable of localizing at sites of cancer due to an interaction between the biomolecule, Q, of the radiopharmaceutical and a receptor or binding site expressed at the site of the cancer or with a receptor or binding site on an endogenous blood component that accumulates at the site; (2) administering said radiopharmaceutical to a patient by injection or infusion; (3) imaging the patient using either planar or SPECT gamma scintigraphy. The radiopharmaceuticals are administered by intravenous injection, usually in saline solution, at a dose of 1 to 100 mCi per 70 kg body weight, or preferably at a dose of 5 to 50 mCi. Imaging is performed using known procedures. The compounds herein described may have asymmetric centers . Compounds of the present invention containing an asymmetrically substituted atom may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis from optically active starting materials . Many geometric isomers of olefins, C=N double bonds, and the like can also be present in the compounds described herein, and all such stable isomers are contemplated in the present invention. Cis and trans geometric isomers of the compounds of the present invention are described and may be isolated as a mixture of isomers or as separated isomeric forms. All chiral, diastereo eric, racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or isomeric form is specifically indicated. All processes used to prepare compounds of the present invention and intermediates made therein are considered to be part of the present invention. The term "substituted, " as used herein, means that any one or more hydrogens on the designated atom is replaced with a selection from the indicated group, provided that the designated atom's normal valency is not exceeded, and that the substitution results in a stable compound. When a substitent is keto (i.e., =0), then 2 hydrogens on the atom are replaced. Keto substituents are not present on aromatic moieties. When a ring system (e.g., carbocyclic or heterocyclic) is said to be substituted with a carbonyl group or a double bond, it is intended that the carbonyl group or double bond be part (i.e., within) of the ring. The present invention is intended to include all isotopes of atoms occurring in the present compounds . Isotopes include those atoms having the same atomic number but different mass numbers. By way of general example and without limitation, isotopes of hydrogen include tritium and deuterium. Isotopes of carbon include C-13 and C-14. When any variable (e.g., R^) occurs more than one time in any constituent or formula for a compound, its definition at each occurrence is independent of its definition at every other occurrence. Thus, for example, if a group is shown to be substituted with 0-2 R^, then said group may optionally be substituted with up to two R6 groups and R^ at each occurrence is selected independently from the definition of R° . Also, combinations of substituents and/or variables are permissible only if such combinations result in stable compounds . When a bond to a substituent is shown to cross a bond connecting two atoms in a ring, then such substituent may be bonded to any atom on the ring. When a substituent is listed without indicating the atom via which such substituent is bonded to the rest of the compound of a given formula, then such substituent may be bonded via any atom in such substituent. Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds . Other features of the invention will become apparent in the course of the following descriptions of exemplary embodiments which are given for illustration of the invention and are not intended to be limiting thereof . Examples 1-Amino-l-deoxy-D-sorbitol, L-aspartic acid dimethyl ester hydrochloride, L-glutamic acid diethyl ester hydrochloride, isonicotinoyl chloride hydrochloride, and N- (2-hydroxyethyl) isonicotinamide, were purchased from Aldrich. Synthesis of functionalized phosphines uses 4, 4 ' , 4"-triphenylphosphine-tricarboxylic acid (p-TPPTC) as the starting material. p-TPPTC was customer-made by the STREM company. Na 9 ^ m Tcθ4 was obtained from a Technelite® ^^Mo/^^ m Υc generator, DuPont Pharma, North Billerica, MA. Instruments. ^H NMR spectra were recorded on a 270 MHz Bruker spectrometer. The ^H NMR data were reported as δ (ppm) relative to TMS . Electrospray MS analyses were performed using a VG Quattro mass spectrometer. LC-MS spectra were collected using a HP1100 LC/MSD system with API-electrospray interface. The high- performance liquid HPLC methods used a Hewlett Packard Model 1090 instrument with radiometric detector using a sodium iodide probe. p-TPPTC-SORB (LI) To suspension of p-TPPTC (1.0 g, 5 mmole) in dry acetonitrile (100 mL) was added triethylamine (1.6 g, 16 mmole) in 5 mL of the same solvent. The resulting mixture was stirred under nitrogen atmosphere until a clear and homogenous solution was obtained. If necessary, the mixture was heated to achieve a clear solution. The solution was stirred at room temperature for 30 min, and was then cooled down to -35 C. Isobutylchloroformate (2.1 g, 15 mmole) was added to give white slurry. The slurry was stirred at -35 C for 20 min, warmed up to 0 - 5 C, and stirred at 0 - 5 C for another 15 min. To the reaction mixture was added 1-amino-1-deoxy-sorbitol (2.75 g, 15 mmole) in 75 mL of DMF (not quite soluble) . The resulting mixture was stirred at 0 - 5 C for 30 min, and then heated to reflux for 2 hours . Solvents were removed under reduced pressure, and to the residue was added 30 mL of acetone, 30 mL of methanol, and 100 mL of diethyl ether to give a sticky gel-like liquid. Solvent was decanted, and discarded. To the residue was added 5 mL of 5 N sodium hydroxide solution, followed by addition of 50 mL of methanol and 50 mL of acetone to give a semi-solid. Solvents were discarded, and the residue was dried overnight under vacuum to give a white foam, which is 1 very hygroscopic. The yield was 2.85 g (65%) . H NMR (in D2O, chemical shifts relative to TMS) : 7.54 (d, 6H, J = 7.6 Hz); 7.08 (t, 6H, J = 7.5 Hz); 3.36 -3.95 (m, 32 . . . 24H) . P NMR ( D2O, chemical shifts ppm relative to phosphate): -6.73. ESMS : M/z = 884.2 (M+1, M = C39H54N3O18P) and 906.2 (M+Na) . p-TPPTC-HEA (L2) To suspension of p-TPPTC (1.0 g, 5 mmole) in dry acetonitrile (150 L) was added triethylamine (1.6 g, 16 mmole) . The resulting mixture was stirred under nitrogen atmosphere until a clear and homogenous solution was obtained. The solution was stirred at room temperature for 30 min, and was then cooled down to -35 C. Isobutylchloro-formate (2.1g, 15 mmole) was added to give a white slurry. The sturry was stirred at -35 C for 15 - 20 min, then warmed up to 0 - 5 C, and stirred at 0 - 5 C for 15 min. To the reaction mixture was added 2- (2-hydroxyethyl) amine (1.9 g, 15 mmole). The resulting mixture was stirred at 0 - 5 C for 30 min, and then heated to reflux for 2 hours. Solvents were removed under reduced pressure, and to the residue was added 5 mL of 5 N sodium hydroxide solution, followed by addition of 20 mL of methanol and 50 mL of acetone to give a thick liquid. Solvents were discarded, and the residue was dried overnight under 1 vacuum to give the product as a semi-solid. H NMR (m D2O, chemical shifts relative to TMS): 7.85 (d, 6H, J = 7.0 Hz); 7.22 (t, 6H, J = 7.0 Hz); 3.10 -3.70 (m, 24H) . 32 P NMR (m D2θ, chemical shifts in ppm relative to phosphate): -6.98 ESMS: M/z = 656.2 (M+1, M C33H42N3O9P) . p-TPPTC-HE was prepared by following the same procedure as that for p-TPPTC-HEA. After removal of solvent, a gummy semi-solid residue was obtained. The residue was dissolved in -20 mL of methanol. Upon addition of diethyl ether (50 mL) , a white precipitate was formed, and then became the gummy liquid again. It was dried overnight under vacuum to give the product as 1 a semi-solid. H NMR (in D2O, chemical shifts relative to TMS): 7.86 (d, 6H, J = 7.1 Hz); 7.30 (t, 6H, J = 7.0 Hz); 3.49 (t, 6H) ; 3.32 (t, 6H) . 32 P NMR (in D2O, chemical shifts in ppm relative to phosphate): -6.95. ESMS (in positive mode): M/z = 524.2 (M+1, M = C27H30N3O6P) • p-TPPTC-GLU (L4) A similar procedure to that for p-TPPTC-SORB was followed to prepare p-TPPTC-GLU except using glutamic acid dimethyl ester instead of 1-amino-l-deoxy-sorbitol . After removal of solvents under reduced pressure, 7 mL of 5 N sodium hydroxide solution was added to the residue. The mixture was stirred at room temperature for 20 - 30 min, followed by addition of 30 mL of acetone and 30 mL of methanol to give a pale yellow solid. The solid was separed by filtration, and was then redissolved 5 mL of water. Upon addition of methanol (50 mL) , a precipitate was formed. The precipitate was filtered off, washed with methanol, and dried under vacuum overnight. The yield was 2.4 g. The 1H NMR data showed that the product i.s a mi.xture of tri.- and difunctionalized p-TPPTC. 1H NMR (m D2O, chemical shifts relative to TMS): 7.85 (d, 6H, J = 7.1 Hz); 7.55 (t, 6H, J = 7.0 Hz); 4.37 (m, 3H) ; 1.92-2.36 (m, 12H) . 32 P NMR (in D2O, chemical shifts in ppm relative to phosphate): -6.42. ESMS (in negative mode): M/z = 802.2 (M+Na-2, M = C36H36N3O15P) . Synthesis of 99mτc Complexes (Stannous Formulation) . To a 10 mL vial was added 0.4 mL of tricine solution (100 mg/mL in 25 mM succinate buffer, pH = 5.0), 0.2 - 0.4 mL of hydrazino nicotinamide (HYNIC) -conjugated biomolecule (50 - 100 μg/mL in 25 mM succinate buffer, pH = 5.0), 0.2 mL of phosphine coligand solution (10 - 25 mg/mL in 25 mM succinate buffer, pH = 5.0), 0.2 - 0.5 mL of 99m Tcθ4 ~ solution (100 - 200 mCi/mL in saline) , and 25 μL of SnCl2-2H2θ solution (1.0 mg/mL in 0.1 N HCI). The reaction mixture was heated at 100 °C for 15 - 20 min. After cooling at room temperature for 10 min, the reaction mixture was analyzed by radio-HPLC. Synthesis of 99m Tc Complexes (Non-Stannous Formulation) . To a 10 mL vial was added 0.2 -0.4 mL of tricine solution (100 mg/mL in 25 mM succinate buffer, pH = 5.0), 0.2 - 0.4 mL of HYNIC-conjugated biomolecule (50 - 100 μg/mL in 25 mM succinate buffer, pH = 5.0), 0.2 -0.5 mL of phosphine coligand solution (20 - 30 mg/mL in 25 mM succinate buffer, pH = 5.0), and 0.2 - 0.5 mL of 99 Tcθ4 ~ solution (100 - 200 mCi/mL in saline) . The reaction mixture was heated at 100 °C for 15 - 20 min, and was then analyzed by radio-HPLC. The TLC method used Gelman Sciences silica-gel paper strips and a 1:1 mixture of acetone and saline as eluant. The HPLC Method used a Zorbax C18, 250 x 4.6 mm Column and a flow rate of 1.0 mL/min. The mobile Phase A contains 10 mM sodium phosphate buffer (pH = 6.0) and the mobile phase B is 100% acetonitrile. The detector uses a sodium iodide (Nal) radiometric probe. The following gradients were used for the characterization of [99m c ] HYNIC _Ln-Q complexes. Gradient A: t (min) 0 30 31 35 36 40 %B 7 12 50 50 7 7 Gradient B: t (min) 0 20 21 26 27 35 %B 0 25 75 75 0 0 Gradient C: t (min) 0 30 31 35 36 40 %B 0 20 70 70 0 0 Gradient D: t (min) 0 20 21 26 27 35 %B 0 75 75 75 0 0 Gradient E: t (min) 0 30 31 35 36 40 %B 5 30 70 70 5 5 Gradient F: t (min) 0 30 31 35 36 40 %B 12 20 70 70 12 12 Ternary Ligand [ 99 Tc]HYNIC-Ln-Q Complexes. New [ 99m Tc]HYNIC-Ln-Q complexes were prepared by direct reduction of [ 99m Tc]pertechnetate with/without stannous chloride in the presence of HYNIC-Ln-Q, tricine and a phosphine coligand. The yields for ternary ligand technetium complexes [ 99 Tc (HYNIC-Ln-Q) (tricine) (L) ] (L = LI - L4) were >70%. Tricine concentration can range from 20 to 60 mg/mL. Using lower tricine concentrations (<20 mg/mL) may result in the formation of a significant amount of [ m Tc] colloid. The phosphine coligand concentration was 1-10 mg/mL. The concentration of the HYNIC-Ln-Q can range from 10 to 50 μg/mL for 50 mCi of [99m r p c ] ertechnetate. Table I summarizes the radio-HPLC data for ternary ligand [ 99m Tc] HYNIC-Ln-Q complexes. In some cases, the ternary ligand technetium complex shows two radiometric peaks in the HPLC chromatogram due to the resolution of two diasteromers of the [ 99m Tc]HYNIC- Ln-Q complexes. In most cases, separation of the two isomeric forms for the ternary ligand [ 99m Tc] HYNIC-Ln-Q complexes are very difficult because of the highly functionalized phosphine coligands. Q-Ln: cyclo (D-Val-NMeArg-Gly-Asp-Mamb ( 5- ( 6-aminohexanamide) ) cyclo (D-Val-NMeArg-Gly-Asp-Mamb ( 5- ( 6-Asp-Asp) hexanamide) ) ) c = cyclo (D-Val-NMeArg-Gly-Asp-Mamb(5- (6-Asp) hexanamide) ) ) d = cyclo (Arg-Gly-Asp-D- (O-aminopropyl) -Tyr-Val) e = cyclo (Arg-Gly-Asp-D-Tyr-Lys) f = cyclo (Arg-Gly-Asp-D-Phe-Lys) g h = Glu-1, 5-bis (cyclo (Arg-Gly-Asp-D- (O-aminopropyl) -Tyr- Val) l = j = cyclo (Arg-Gly-Asp-Lys-Val ) k = D-Phe- (6-aminohexanamide) -Thr-Lys-Pro-Pro-Arg. (The arrow indicates the position for attachment of chelator) . 1 = D-Tyr- (6-aminohexanamide) -Thr-Lys-Pro-Pro-Arg. (The arrow indicates the position for attachment of chelator) . m = 6-aminohexanamide-Thr-Lys-Pro-Pro-Arg. (The arrow indicates the position for attachment of chelator) . n = N-f ormyl-Met-Leu-Phe-Lys o = N- (N-isopropylurea ( Phe-Leu-Phe-Leu-Phe) - propylenedi amine 4- [ (3-bromophenyl) amino] -7- [3- (HYNIC) amidopropylammo; pyrido [4, 3- ]pyrimidine Table 3. New ternary ligand technetium complexes, [ 99m Tc (HYNIC-Ln-Q) (tricine) (phosphine) ] and their HPLC data. * HPLC purified. VRA= vitronectin receptor antagonists TKI= tyrosine kinase inhibitors Although this invention has been described with respect to specific embodiments, the details of these embodiments are not to be construed as limitations. Various equivalents, changes and modifications may be made without departing from the spirit and scope of this invention, and it is understood that such equivalent embodiments are part of this invention. UTILITY The radiopharmaceuticals provided herein are useful as imaging agents for the diagnosis of cardiovascular disorders, such as thromboembolic disease or atherosclerosis, infectious disease and cancer. The radiopharmaceuticals are comprised of 99m Tc labeled hydrazino or diazenido modified biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. Canine Deep Vein Thrombosis Model. This model incorporates the triad of events (hypercoagulatible state, period of stasis, low shear environment) essential for the formation of a venous fibrin-rich actively growing thrombus . The procedure was as follows: Adult mongrel dogs of either sex (9-13 kg) were anesthetized with pentobarbital sodium (35 mg/kg,i.v.) and ventilated with room air via an endotracheal tube (12 strokes/min, 25 ml/kg) . For arterial pressure determination, the right femoral artery was cannulated with a saline-filled polyethylene catheter (PE-240) and connected to a Statham pressure transducer (P23ID; Oxnard,CA). Mean arterial blood pressure was determined via damping the pulsatile pressure signal. Heart rate was monitored using a cardiotachometer (Biotach, Grass Quincy, MA) triggered from a lead II electrocardiogram generated by limb leads. The right femoral vein was cannulated (PE-240) for drug administration. A 5 cm segment of both jugular veins was isolated, freed from fascia and circumscribed with silk suture. A microthermister probe was placed on the vessel which serves as an indirect measure of venous flow. A balloon embolectomy catheter was utilized to induce the 15 min period of stasis during which time a hypercoagulatible state was then induced using 5 U thrombin (American Diagnosticia, Greenwich CT) administered into the occluded segment. Fifteen minutes later, flow was reestablished by deflating the balloon. The radiopharmaceutical was infused during the first 5 minutes of reflow and the rate of incorporation monitored using gamma scintigraphy. Canine Arteriovenous Shunt Model . Adult mongrel dogs of either sex (9-13kg) were anesthetized with pentobarbital sodium (35 mg/kg,i.v.) and ventilated with room air via an endotracheal tube (12 strokes/min, 25 ml/kg) . For arterial pressure determination, the left carotid artery was cannulated with a saline-filled polyethylene catheter (PE-240) and connected to a Statham pressure transducer (P23ID; Oxnard,CA). Mean arterial blood pressure was determined via damping the pulsatile pressure signal. Heart rate was monitored using a cardiotachometer (Biotach, Grass Quincy, MA) triggered from a lead II electrocardiogram generated by limb leads. A jugular vein was cannulated (PE-240) for drug administration. The both femoral arteries and femoral veins were cannulated with silicon treated (Sigmacote, Sigma Chemical Co. St Louis, MO), saline filled polyethylene tubing (PE-200) and connected with a 5 cm section of silicon treated tubing (PE-240) to form an extracorporeal arterio-venous shunts (A-V) . Shunt patency was monitored using a doppler flow system (model VF-1, Crystal Biotech Inc, Hopkinton, MA) and flow probe (2-2.3 mm, Titronics Med. Inst., Iowa City, IA) placed proximal to the locus of the shunt. All parameters were monitored continuously on a polygraph recorder (model 7D Grass) at a paper speed of 10 mm/min or 25 mm/sec. On completion of a 15 min post surgical stabilization period, an occlusive thrombus was formed by the introduction of a thrombogenic surface (4-0 braided silk thread, 5 cm in length, Ethicon Inc., Somerville, NJ) into the shunt one shunt with the other serving as a control. Two consecutive lhr shunt periods were employed with the test agent administered as an infusion over 5 min beginning 5 min before insertion of the thrombogenic surface. At the end of each 1 hr shunt period the silk was carefully removed and weighed and the % incorporation determined via well counting. Thrombus weight was calculated by subtracting the weight of the silk prior to placement from the total weight of the silk on removal from the shunt. Arterial blood was withdrawn prior to the first shunt and every 30 min thereafter for determination of blood clearance, whole blood collagen-induced platelet aggregation, thrombin- induced platelet degranulation (platelet ATP release) , prothrombin time and platelet count . Template bleeding time was also performed at 30 min intervals. Complexes in which the biologically active molecules, Q, are chemotactic peptides can be evaluated for potential clinical utility as radiopharmaceuticals for the diagnosis of infection by performing imaging studies in a guinea pig model of focal infection. Guinea Pig Focal Infection Model. Hartley guinea pigs; unspecified sex; weight between 200-250 grams are fasted overnight prior to the procedure . Each guinea pig is anesthetized with a mixture of ketamine 25-55 mg/kg//IM and xylazine 2-5 mg/kg/IM. A #10 trochar needle is used to introduce a 2 inch piece of umbilical string that has been immersed in a 6% sodium caseinate solution (this is the chemoattractant) into the right flank and is placed on the left side of the peritoneal cavity. The placement of the chemoattractant serves as a focal site for white blood cell recruitment. The puncture site is sealed with Nexabain, a skin glue (if required) . The animals are allowed to recover for 18 hrs . Eighteen hours later the guinea pigs are anesthetized with kettamine 25-55 mg/kg//IM and xylazine 2-5 mg/kg/IM to achieve Stage Ill/Plane III of anesthesia and insure proper injection of the test agent into the lateral saphenous vein. Once the test agent is administered the guinea pigs are placed behind a lead shield and monitored for 1-4 hours. At the appropriate time postinjection, the animals are euthanized with pentobarbital sodium 65 mg/kg, I.V., and a biodistribution performed. Throughout the course of the study, blood samples are withdrawn via cardiac puncture. All publications, patents, and patent documents are incorporated by reference herein, in their entirety, as though individually incorporated by reference. Obviously, numerous modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that within the scope of the appended claims, the invention may be practiced otherwise that as specifically described herein.

Claims: WHAT IS CLAIMED IS: 1. An ancillary ligand (AL2) of the formula: or pharmaceutically acceptable salt form thereof; wherein: R^ 7 is independently selected, at each occurrence, from the group consisting of: C(0)R 68 , S(0) 2 R 68 , P(0)(OR 68 ), C(0)NR 68 R 69 , S(0) 2 NR 68 R 69 , and C(0)OR 68 ; R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , C2-10 alkenyl substituted with 1-5 R 70 and 0-2 R 70a , c 2-10 alkynyl substituted with 1-5 R 7 ^ and 0-2 R 70a , aryl substituted with 1-4 R 70 and 0-1 R 7 0 a , C3-10 heterocycle substituted with 1-4 R 7 0 and 0-1 R 7( ^a anc j C3-10 carbocycle substituted with 1-3 R 70 and 0-2 R 70a ; R^ 9 is independently selected, at each occurrence, from the group consisting of: H, Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , C2-10 alkenyl substituted with 1-5 R 70 and 0-2 R 70a , C2-10 alkynyl substituted with 1-5 R 71 -* and 0-2 R 70a , aryl substituted with 1-3 R 70 and 0-2 R 7 0a C3-10 heterocycle substituted with 1-4 R 7 0 and 0-1 R 7( ^ a , and C3-10 carbocycle substituted with 1-4 R 70 and 0-1 R 70a ; R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 7 -'-, -CO2R 71 , -OC(=0)R 71 ,-OC(=0)OR 71 , -OCH2CO2R 71 , -NR 72 C(=0)OR 71 , -S02R 71a , -Sθ3R 71a , - NR 72 S02R 71a , -Pθ3R 71a and Cl-10 alkyl substituted with 1-5 -OR 71 ; i s independently selected, at each occurrence, from the group consisting of: =0, F, Cl, Br, I, -CF3, -CN, -N02, -C(=0)R 71 , -C (=0) N (R 71 ) 2 , -N(R 71 )3 + , -OC(=0)N(R 71 )2. -NR 71 C (=0) R 71 , -NR 72 C(=0)OR 71a , -NR 71 C(=0)N(R 71 )2, -NR 72 S02N(R 71 )2, -Sθ2N(R 71 )2, and -N (R 71 ) 2 ; • R 7 ^ is independently selected, at each occurrence, from the group consisting of: H and Ci-Cς alkyl substituted with 0-5 hydroxyl substituents; R 7 ^ a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 0-5 hydroxyl substituents; and, -131 R 72 is independently selected, at each occurrence, from the group consisting of: H and Cχ-C6 alkyl substituted with 0-5 hydroxyl substituents . 2. A compound according to claim 1 wherein: R° is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , -CO2R 71 and Ci-io alkyl substituted with 1-5 -OR 71 . 3. A compound according to claim 1 wherein: R 67 is C(0)NR β8 R 69 ; R^ is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 7 ° a ; R 69 is H; and R 7 ^ is independently selected, at each occurrence, from the group consisting of: Ci alkyl substituted with -OR 71 , -OR 71 , -Sθ3R 71a , and -CO2R 71 . 4. A compound according to claim 1 wherein: R 67 is C(0)NR 68 R 69 ; R^ is independently selected, at each occurrence, from the group consisting of: Cι_6 alkyl substituted with 1-5 R 70 and 0-2 R 70 , and C5--6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7( ^ is independently selected, at each occurrence, from the group consisting of: Ci alkyl substituted with -OR 71 , -OR 71 , -Sθ3R 71 , -CO2R 71 . 5. A compound according to claim 1 wherein: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-6 alkyl substituted with 1-5 R 70 and 0-2 R 70a ; R^ 9 is hydrogen; R 70 is -OR 71 , -S03R 71a , -CO2R 71 ; R 71 is H; and R 71a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 1-5 hydroxyl substituents. 6. A compound according to claim 1 wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is C1-3 alkyl substituted with 1-3 R 70 ; R^ is hydrogen; R 70 is -OR 71 , -S03R 71a , or -CO2R 71 ; and R 7 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl substituted with 1-2 hydroxyl substituents . 7. A compound according to claim 1 wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is C1-2 alkyl substituted with 1-2 R 70 ; R^ 9 is hydrogen; R 70 is -OR 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl substituted with 1-2 hydroxyl substituents . 8. A compound according to claim 1 wherein: the ancillary ligand is of the formula: R 67 is C(0)NR β8 R 69 ; R 68 is C1-3 alkyl substituted with 1-3 R 70 ; R6 9 is hydrogen; R 70 is -Sθ3R 71a or -CO2R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Cι_-2 alkyl. 9. A compound according to claim 1 wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is C1-3 alkyl substituted with 0-3 -OR 70 and 0-1 R 70 ; R^ 9 is hydrogen; R 70 is -CO2R 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and C1--2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Cχ-C6 alkyl substituted with 0-5 hydroxyl substituents. 10. A compound according to claim 1 wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R^ 8 is independently selected, at each occurrence, from the group consisting of: tetrohydropyranyl substituted with 1-4 R 70 and 0-1 R 7 ^ 8 -, and tetrohydrofuranyl substituted with 1-3 R 70 and 0-1 R 71a ; R^ 9 is hydrogen; R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , and Ci alkyl substituted with -OR 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Cχ-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Cι-C6 alkyl substituted with 0-5 hydroxyl substituents. 11. A compound according to claim 1 selected from the group : ; or pharmaceutically acceptable salts thereof. 12. A radiopharmaceutical comprising an ancillary ligand according to claim 1, chelated with a radionuclide selected from the group consisting of: 99m TC/ 186 Re and 188 Re . 13. A radiopharmaceutical according to claim 12, wherein: R^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5--6 heterocyclyl substituted with -OR 71 l-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , -CO2R 71 and Ci-6 alkyl substituted with 1-5 -OR 71 . 14. A radiopharmaceutical according to claim 12, wherein: R 67 is C(0)NR β8 R 69 ; R" 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , -CO2R 71 and C±-β alkyl substituted with 1-5 -OR 71 . 15. A radiopharmaceutical according to claim 12, wherein: R 67 is C(0)NR 68 R 69 ; R° 8 is independently selected, at each occurrence, from the group consisting of: C -β alkyl substituted with 1-5 R 70 and 0-2 R 70a , and 05.5 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , -CO2R 71 and Ci-6 alkyl substituted with 1-5 -OR 71 . 16. A radiopharmaceutical according to claim 12, wherein: R 67 is C(0)NR β8 R 69 ; R 68 is Ci-6 alkyl substituted with 1-5 R 70 and 0-2 R 70a ; R^ 9 is hydrogen; R 70 is -OR 71 , -S03R 71a , -CO2R 71 ; R 71 is H; and R 1a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 1-5 hydroxyl substituents. 17. A radiopharmaceutical according to claim 12, wherein : the ancillary ligand is of the formula: R 67 is C(0)NR β8 R 69 ; R 68 is C1-3 alkyl substituted with 1-3 R 70 ; R^ is hydrogen; R 70 is -OR 71 , -Sθ3R 71a , or -CO2R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl substituted with 1-2 hydroxyl substituents. 18. A radiopharmaceutical according to claim 12, wherein : the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-2 alkyl substituted with 1-2 R 70 ; R° 9 is hydrogen; R 70 is -OR 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl substituted with 1-2 hydroxyl substituents . 19. A radiopharmaceutical according to claim 12, wherein : the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-3 alkyl substituted with 1-3 R 70 ; R^ is hydrogen; R 70 is -S03R 71a or -CO2R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and C1-2 alkyl. 20. A radiopharmaceutical according to claim 12, wherein: the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is C1-.3 alkyl substituted with 0-3R 70 and 0-1 R 70a ; R° 9 is hydrogen; R 70 is -C02R 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and C±-CQ alkyl substituted with 0-5 hydroxyl substituents. 21. A radiopharmaceutical according to claim 12, wherein : the ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R^ 8 is independently selected, at each occurrence, from the group consisting of: tetrohydropyranyl substituted Wlith 1-4 R 70 and 0-1 R 70a , and tetrohydrofuranyl substituted with 1-3 R 70 and 0-1 R 71a ; R^ 9 is hydrogen; R 7 ^ is independently selected, at each occurrence, from the group consisting of: -OR 71 , and Ci alkyl substituted with -OR 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Cι~C6 alkyl substituted with 0-5 hydroxyl substituents. 22. A radiopharmaceutical according to claim 12, wherein the ancillary ligand (AL2) is selected from the group consisting of: 23. A radiopharmaceutical of the formula: [ (Q)d'Ln-Ch']χ-Mt(ALl)y(A L 2 ) z ( X or pharmaceutically acceptable salts thereof wherein, A 2 an ancillary ligand of claim 1; ALI is a first ancillary ligand and is a- dioxygen ligand or a functionalized aminocarboxylate; Q is a biologically active group; d' is 1 to 20; L n is a linking group of formula: M 1 - [Y 1 (CR 55 R 56 ) f (Z 1 ) f "Y 2 ] f ' -M 2 , M 1 is -[(CH2)gZ 1 ]g'-(CR 55 R 5β )g»-; M 2 is -(CR 55 R 56 )g » -[Z 1 (CH2)g]g'-; g is independently 0-10; g' is independently 0-1; g" is independently 0-10; f is independently 0-10; f is independently 0-10; f" is independently 0-1; Y 1 and Y 2 , at each occurrence, are independently selected from: a bond, 0, NR 56 , C=0, C(=0)0, OC(=0)0, C(=0)NH-, C=NR 56 , S, SO, Sθ2 , SO3 , NHC(=0), (NH)2C(=0), and (NH)2C=S; Z is independently selected at each occurrence from a C6-C14 saturated, partially saturated, or aromatic carbocyclic ring system, substituted with 0-4 R^ 7 ; and a heterocyclic ring system, optionally substituted with 0-4 R 57 ; R55 and R^6 are independently selected at each occurrence from: H, C1-C10 alkyl substituted with 0-5 R^ 7 , and alkaryl wherein the aryl is substituted with 0-5 R 57 ; R^ 7 is independently selected at each occurrence from the group: H, OH, NHR 58 , C(=0)R 58 , OC(=0)R 58 , OC(=0)OR 58 , C(=0)OR 58 , C(=0)NR 58 , -CN, SR 58 , SOR 58 , S02R 58 , NHC(=0)R 58 , NHC(=0)NHR 58 , and NHC (=S)NHR 58 , alternatively, when attached to an additional molecule Q, R^ 7 is independently selected at each occurrence from the group: 0, NR 58 , C=0, C(=0)0, 0C(=0)0, C(=0)N, C=NR 58 , S, SO, S02, SO3, NHC(=0), (NH)2C(=0), and (NH)2C=S; R^ 8 is independently selected at each occurrence from the group: H, C1-C6 alkyl, benzyl, and phenyl; x, y and z are independently 1 or 2; Mt is a transition metal radionuclide selected from the group: 99m Tc, 186 Re and 188 Re; Ch' is a radionuclide metal chelator coordinated to transition metal radionuclide Mt, and is independently selected at each occurrence, from the group: R 0 N=N+=, R 0 R 1 N-N=, and R 0 N=N (H) - ; R ^ is independently selected at each occurrence from the group: a bond to L n , C1-C10 alkyl substituted with 0-3 R^ 2 , aryl substituted with 0-3 R^ 2 , cycloaklyl substituted with 0-3 R^ , heterocycle substituted with 0-3 heterocycloalkyl substituted with 0-3 R^ 2 , aralkyl substituted with 0-3 R 52 and alkaryl substituted with 0-3 R 52 ; R 41 is independently selected from the group: H, aryl substituted with 0-3 R^ 2 , Cι-Cχo alkyl substituted with 0-3 R^ , and a heterocycle substituted with 0- 3 R 52 ; R 52 is independently selected at each occurrence from the group: a bond to L n , =0, F, CI, Br, I, -CF3 , - CN, -C02R 53 , -C(=0)R 53 , -C(=0)N(R 53 )2, -CHO, -CH2OR 53 , -OC(=0)R 53 , -OC(=0)OR 53a , -OR 53 , -OC(=0)N(R 53 )2, -NR 53 C(=0)R 53 , -N(R 53 )3 + , -NR 5 C(=0)OR 53a , -NR 53 C(=0)N(R 53 )2, -NR 5 S02N(R 53 )2, -NR 5 S02R 53a , -SO3H, -Sθ2R 53a , -SR 53 , -S(=0)R 53 , -S02N(R 53 )2, -N(R 53 )2, -NHC(=NH)NHR 53 , -C (=NH) HR 53 , =NOR 53 , NO2 , -C(=0)NHOR 53 , -C(=0)NHNR 53 R 53a , -OCH2CO2H, and 2- (1-morpholino) ethoxy; R 53 , R^3a and R 54 are each independently selected at each occurrence from the group: H, C1-C6 alkyl, and a bond to L n . 24. The radiopharmaceutical of Claim 23 wherein: Q is a biomolecule selected from the group: Ilb/IIIa receptor antagonists, Ilb/IIIa receptor ligands, fibrin binding peptides, leukocyte binding peptides, chemotactic peptides, somatostatin analogs, selectin binding peptides, vitronectin receptor antagonists, and tyrosine kinase inhibitors; d' is 1 to 3; L n is: -(CR 55 R 56 ) g »-[Y 1 (CR 55 R 56 )fY 2 ]f -(CR 55 R 56 )g--, g" is 0-5, f is 0-5 f is 1-5 Y 1 and Y 2 , at each occurrence, are independently selected from: 0, NR 56 , C=0, C(=0)0, OC(=0)0, C(=0)NH, C=NR 56 , S, SO, S02. SO3 , NHC(=0), (NH)2C(=0), and (NH)2C=S; R 55 and R^6 are independently selected at each occurrence from: H, Cι_-Cιo alkyl and alkaryl; x and y are 1 ; Mt is 99m Tc; Ch' is R 0 N=N+= or R 0 R 1 N-N=; R 0 is independently selected at each occurrence from the group: aryl substituted with 0-3 R 52 , and heterocycle substituted with 0-3 R 52 ; R 4 is independently selected from the group: H, aryl substituted with 0-1 R 52 , C1-C3 alkyl substituted with 0-1 R 52 , and a heterocycle substituted with 0- 1 R 52 ; R 5 is independently selected at each occurrence from the group: a bond to L n , -CO2R 53 , -CH2OR 53 , -SO3H, -S02R 53a , -N(R 53 )2. -N(R 53 )3+, -NHC (=NH) NHR 53 , and -OCH2CO2H; R 5 and R 5 a are each independently selected at each occurrence from the group: H and C1-C3 alkyl; ALI is a functionalized aminocarboxylate; AL2 an ancillary ligand of formula: R^ 8 is independently selected, at each occurrence, from the group consisting of: Cι_-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70 ; R 69 is H; and R 7 ^ is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , or - CO2R 71 , and Ci-6 alkyl substituted with 1-5 -OR 71 . 25. The radiopharmaceutical of Claim 23 wherein: Q is a biomolecule selected from the group: Ilb/IIIa receptor antagonists and chemotactic peptides; d' is 1; Y 1 and Y 2 , at each occurrence, are independently selected from: 0, NR 56 , C=0, C(=0)0, OC(=0)0, C(=0)NH, C=NR 56 , NHC(=0), and (NH)2C(=0); R 55 and R 56 are H; z is 1; R ^ is a heterocycle substituted with R 52 ; R 41 is H; R 52 is a bond to L n ; ALI i tricine; AL2 i an ancillary ligand of R 67 is C(0)NR 68 R 69 ; ^ 8 is independently selected, at each occurrence, from the group consisting of: Ci-io alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5-6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and ■ R 7 0 and is independently selected, at each occurrence, from the group consisting of: -OR 71 , -Sθ3R 71a , - CO2R 71 and Ci-io alkyl substituted with 1-5 -OR 71 . 26. The radiopharmaceutical according to claim 23, wherein: L2 s an ancillary ligand of formula: R 67 is C(0)NR 68 R 69 ; R^ is independently selected, at each occurrence, from the group consisting of: C -ζ alkyl substituted with 1-5 R 70 and 0-2 R 70a , and C5--6 heterocyclyl substituted with 1-4 R 70 and 0-1 R 70a ; R 69 is H; and R 70 is -OR 71 , -S03R 71a , -C02R 71 . 27. The radiopharmaceutical according to claim 23, wherein : AL2 is an ancillary ligand of formula: R 67 is C(0)NR 68 R 69 ; R 68 is Cι_6 alkyl substituted with 1-5 R 70 and 0-2 R 70a ; R° 9 is hydrogen; R 70 is -OR 71 , -S03R 71a , -C02R 71 ; R 71 is H; and R 71a is independently selected, at each occurrence, from the group consisting of: H and C1-C6 alkyl substituted with 1-5 hydroxyl substituents . 28. The radiopharmaceutical according to claim 23, wherein : A 2 is ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-3 alkyl substituted with 1-3 R 70 ; R^ is hydrogen; R 70 is -OR 71 , -S03R 71a , or -C02R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl substituted with 1-2 hydroxyl substituents. 29. The radiopharmaceutical according to claim 23, wherein : A 2 is ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Cι_2 alkyl substituted with 1-2 R 70 ; R^ 9 is hydrogen; R 70 is -OR 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Cι_2 alkyl substituted with 1-2 hydroxyl substituents. 30. The radiopharmaceutical according to claim 23, wherein : AL2 is ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R 68 is Ci-3 alkyl substituted with 1-3 R 70 ; R^ 9 is hydrogen; R 70 is -Sθ3R 71a or -CO2R 71 ; and R 71 is independently selected, at each occurrence, from the group consisting of: H and Ci-2 alkyl. 31. The radiopharmaceutical according to claim 23, wherein: AL2 is ancillary ligand is of the formula: R 67 is C(0)NR β8 R 69 ; R 68 Cι_3 alkyl substituted with 1-3 R 70 and 0-3 R 70a ; R^ 9 is hydrogen; R 70 is -C02R 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Cχ-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Ci-Cβ alkyl substituted with 0-5 hydroxyl substituents. 32. The radiopharmaceutical according to claim 23, wherein : AL2 i ancillary ligand is of the formula: R 67 is C(0)NR 68 R 69 ; R^ is independently selected, at each occurrence, from the group consisting of: tetrohydropyranyl substituted with 1-4 R 7 0 and 0-1 R 7 ^ 9 -, and tetrohydrofuranyl substituted with 1-3 R 70 and 0-1 R 71 ; R^ is hydrogen; R 7 0 is independently selected, at each occurrence, from the group consisting of: -OR 71 , and Cj_ alkyl substituted with 1 -OR 71 ; R 71 is independently selected, at each occurrence, from the group consisting of: H and Cχ-2 alkyl; and R 71a is independently selected, at each occurrence, from the group consisting of: H and Cι~C6 alkyl substituted with 0-5 hydroxyl substituents. 33. The radiopharmaceutical according to claim 23, wherein: AL2 i selected from the group: and ; or pharmaceutically acceptable salts thereof. 34. The radiopharmaceutical of Claim 23 wherein: Q is d' is 1 ; L n is attached to Q at the carbon atom designated with a * and has the formula: - (C=0) NH (CH2 ) 5C (=0) NH- ; attached to L n at the carbon atom designated with a Mt is 99m Tc; and ALI is tricine. 35. A radiopharmaceutical according to claim 23 wherein the Q-Ln moiety is selected from the group: , wherein * indicates the point of attachment to the chelator moiety (Ch) . 6. A radiopharmaceuitcal according to Claim 23, wherein the radiopharmaceutical is selected from the group: -168- -193- a pharmaceutically acceptable salt form thereof 37. A method for radioimaging a patient comprising: (i) administering to said patient an effective amount of a radiopharmaceutical of Claim 23 ; and (ii) scanning the patient using a radioimaging device. 38. A method for visualizing sites of platelet deposition in a patient by radioimaging, comprising: (i) administering to said patient an effective amount of a radiopharmaceutical of Claim 23 ; and (ii) scanning the patient using a radioimaging device; wherein Q is a Ilb/IIIa receptor ligand or fibrin binding peptide . 39. A method of determining platelet deposition in a patient comprising: (i) administering to said patient a radiopharmaceutical composition of Claim 23; and (ii) imaging said patient; wherein Q is a Ilb/IIIa receptor ligand or fibrin binding peptide . 40. A method of diagnosing a disorder associated with platelet deposition in a patient comprising: (i) administering to said patient a radiopharmaceutical composition of Claim 23; and (ii) imaging said patient; wherein Q is a Ilb/IIIa receptor ligand or fibrin binding peptide. 41. A method of diagnosing thromboembolic disorders or atherosclerosis in a patient, comprising: (i) administering to said patient a radiopharmaceutical composition of Claim 23 ; and (ii) generating a radioimage of at least a part of said patient's body; wherein Q is a Ilb/IIIa receptor ligand or fibrin binding peptide . 42. A method of diagnosing infection, inflammation or transplant rejection in a patient, comprising: (i) administering to said patient a radiopharmaceutical composition of Claim 23 ; and (ii) generating a radioimage of at least a part of said patient's body; wherein Q is selected from the group consisting of a leukocyte binding peptide, a chemotactic peptide, and a LTB receptor antagonist. 43. A method of detecting new angiogenic vasculature in a patient, comprising: (i) administering to said patient a radiopharmaceutical composition of Claim 23 ; and (ii) generating a radioimage of at least a part of said patient's body; wherein Q is a vitronectin receptor antagonist, a somatostatin analog, or a growth factor receptor antagonist. 44. A kit for forming a radiopharmaceutical complex comprising the following components: (i) an ancillary ligand of claim 1; (ii) optionally a reducing agent; and (iii) instructions for reacting the components of said kit with a radionuclide solution. 45. A kit for preparing a radiopharmaceutical comprising: (b) a predetermined quantity of a sterile, pharmaceutically acceptable first ancillary ligand, AL2 , of Claim 1; (b) a predetermined quantity of a sterile, pharmaceutically acceptable reagent of formula: ( Q ) d'Ln-Ch; (c) a predetermined quantity of a sterile, pharmaceutically acceptable second ancillary ligand, A I. selected from the group: a dioxygen ligand and a functionalized aminocarboxylate; (d) a predetermined quantity of a sterile, pharmaceutically acceptable reducing agent; and (e) optionally, a predetermined quantity of one or more sterile, pharmaceutically acceptable components selected from the group: transfer ligands, buffers, lyophilization aids, stabilization aids, solubilization aids and bacteriostats; wherein : Q is a biomolecule; d' is 1 to 20; L n is a linking group of formula: M 1 - [Y 1 (CR 55 R 56 ) f (Z 1 ) f "Y 2 ] f ' -M 2 , M 1 is -[(CH2)gZ 1 ]g'-(CR 55 R 56 )g»-; M 2 is -(CR 55 R 5β )g"-[Z 1 (CH2)g]g'-; g is independently 0-10; g' is independently 0-1; g" is independently 0-10; f is independently 0-10; f is independently 0-10; f" is independently 0-1; γl and γ2 , at each occurrence, are independently selected from: a bond, 0, NR 5β , C=0, C(=0)0, OC(=0)0, C(=0) H-, C=NR 56 , S, SO , S02 , SO3 , NHC(=0), ( H)2C{=0), and (NH)2C=S; iX is independently selected at each occurrence from a C 6 -C 14 saturated, partially saturated, or aromatic carbocyclic ring system, substituted with 0-4 R57 ; and a heterocyclic ring system, optionally substituted with 0-4 R 57 ; R55 and R^6 are independently selected at each occurrence from: H, C1-C10 alkyl substituted with 0-5 R57, and alkaryl wherein the aryl is substituted with 0-5 R^7 ; R57 is independently selected at each occurrence from the group: H, OH, NHR 58 , C(=0)R 58 , OC(=0)R 58 , OC(=0)OR 58 , C(=0)OR 58 , C(=0)NR 58 , -CN, SR 58 , SOR 58 , S02R 58 , NHC(=0)R 58 , NHC(=0)NHR 58 , and NHC (=S)NHR 58 , alternatively, when attached to an additional molecule Q, R 57 is independently selected at each occurrence from the group: 0, NR 58 , C=0, C(=0)0, 0C(=0)0, C(=0)N, C=NR 58 , S, SO, S02, SO3 , NHC(=0), (NH)2C(=0), and (NH)2C=S; R 58 is independently selected at each occurrence from the group: H, Ci-Cς alkyl, benzyl, and phenyl; x, y and z are independently 1 or 2; Mt is a transition metal radionuclide selected from the group: 9 9m Tc, l 86 Re and 188 Re; Ch' is a radionuclide metal chelator coordinated to transition metal radionuclide Mt, and is independently selected at each occurrence, from the group: R 0 N=N + =, R 0 R 41 N-N=, and R 0 N=N(H)-; R 4 ^ is independently selected at each occurrence from the group: a bond to L n , C1-C10 alkyl substituted with 0-3 R 52 , aryl substituted with 0-3 R 52 , cycloaklyl substituted with 0-3 R 52 , heterocycle substituted with 0-3 R 52 . heterocycloalkyl substituted with 0-3 R 52 , aralkyl substituted with 0-3 R 5 and alkaryl substituted with 0-3 R 5 ; R ^- is independently selected from the group: H, aryl substituted with 0-3 R 5 , C1-C10 alkyl substituted with 0-3 R 52 , and a heterocycle substituted with 0- 3 R5 ; R 5 is independently selected at each occurrence from the group: a bond to L n , =0, F, CI, Br, I, -CF3 , - CN, -C02R 53 , -C(=0)R 53 , -C(=0)N(R 53 )2, -CHO, -CH20R 53 , -OC(=0)R 53 , -OC(=0)OR 53 , -OR 53 , -OC(=0)N(R 53 )2, -NR 53 C(=0)R 53 , -N(R 53 )3+, -NR 54 C(=0)OR 53a , -NR 53 C(=0)N(R 53 )2. -NR 5 S02N(R 53 )2, -NR 54 S02R 53a , -SO3H, -Sθ2R 53a , -SR 53 , -S(=0)R 53a , -S02N(R 53 )2 -N(R 53 )2. -NHC(=NH)NHR 53 , -C (=NH) NHR 53 , =NOR 53 , N02 , -C(=0)NHOR 53 , -C(=0)NHNR 53 R 53a , -OCH2CO2H, and 2- (1-morpholino) ethoxy; and R 53 , R53a ? and R 54 are each independently selected at each occurrence from the group: H, C]_-C6 alkyl, and a bond to L n . 46. A kit according to claim 45, wherein the Q-Ln moiety is selected from the group: , wherein * indicates the point of attachment to the chelator moiety (Ch) . 47. A diagnostic composition comprising a diagnostic effective amount of the radiopharmaceutical of claim 23 and a pharmaceutically acceptable carrier. A. CLASSIFICATION OF SUBJECT MATTER IPC 7 C07F9/50 C07F13/00 C07H13/08 C07B59/00 A61K51/04 C07K14/745 C07K7/02 C07K5/02 C07K7/06 According to International Patent Classification (IPC) or to both national classification and IPG B. FIELDS SEARCHED Minimum documentation searched (classification system followed by classification symbols) IPC 7 C07F C07H C07B A61K C07K Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched Electronic data base consulted during the international search (name of data base and, where practical, search terms used) CHEM ABS Data, EPO-Internal C. DOCUMENTS CONSIDERED TO BE RELEVANT Category " Citation of document, with indication, where appropnate, of the relevant passages Relevant to claim No LIU S ET AL: "A NOVEL TERNARY LIGAND 1-47 SYSTEM FOR 99MTC-LABELIN6 OF HYDRAZINO NICOTINAMIDE-MODIFIED BIOLOGICALLY ACTIVE MOLECULES USING IMINE-N- CONTAINING HETEROCYCLES AS COLIGANDS" BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 9, no. 5, 1 September 1998 ( 1998-09-01 ) , pages 583-595, XP000778001 ISSN: 1043-1802 the whol e document WO 96 40637 A (THE DUPONT MERCK 1-47 PHARMACEUTICAL CO.) 19 December 1996 (1996-12-19) the whol e document -/- Further documents are listed in the continuation of box C Patent family members are listed in annex ° Special categories of cited documents "T" later document published after the international filing date or pnonty date and not in conflict with the application but "A" document defining the general state of the art which is not cited to understand the principle or theory underlying the considered to be of particular relevance invention "E" earlier document but published on or after the international "X" document of particular relevance, the claimed invention filing date cannot be considered novel or cannot be considered to "L" document which may throw doubts on pnonty claιm(s) or involve an inventive step when the document is taken alone which is cited to establish the publication date of another ■ Y" document of particular relevance, the claimed invention citation or other special reason (as specified) cannot be considered to involve an inventive step when the "O" document referring to an oral disclosure, use, exhibition or document is combined with one or more other such docuother means ments, such combination being obvious to a person skilled "P" document published prior to the international filing date but in the art later than the priority date claimed ■ &" document member of the same patent family Date of the actual completion of the international search Date of mailing of the international search report 13 August 2001 21/08/2001 Name and mailing address of the ISA Authorized officer European Patent Office, P B 5818 Pateπtlaan 2 NL- 2280 HV Rl]SWllk Tel (+ 3 1-70) 3 0-20 0, Tx 31 651 epo nl, Fax (+31-70) 3 4 0-3016 Besl i er , L Form PCT/ISA/210 (second sheet) (July 1992) C(Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category ° Citation of document, with indication.where appropπate, of the relevant passages Relevant to claim No A WO 96 31243 A (THE DUPONT MERCK 1-47 PHARMACEUTICAL CO.) 10 October 1996 (1996-10-10) ci ted i n the appl i cati on the whol e document US 5360895 A (JAMES F. HAINFELD) 1-47 1 November 1994 (1994-11-01) the whol e document Form PCT/ISA/210 (continuation of second sheet) (July 1992) Patent document Publication Patent family Publication cited in search report date τιember(s) date WO 9640637 A 19-12-1996 US 5750088 A 12-05-1998 AU 718683 B 20-04-2000 AU 6166196 A 30-12-1996 BR 9609003 A 14-12-1999 CA 2222183 A 19-12-1996 CN 1192733 A 09-09-1998 CZ 9703801 A 15-07-1998 EE 9700313 A 15-06-1998 EP 0832068 A 01-04-1998 HR 960250 A 31-12-1997 HU 9901469 A 30-08-1999 JP 11507364 T 29-06-1999 LT 97191 A, B 27-04-1998 LV 12044 A 20-05-1998 LV 12044 B 20-09-1998 NO 975678 A 06-02-1998 PL 323995 A 27-04-1998 SI 9620076 A, B 31-08-1998 SK 163497 A 07-10-1998 US 6015904 A 18-01-2000 WO 9631243 A 10-10-1996 US 5744120 A 28-04-1998 AU 719529 B 11-05-2000 AU 5787496 A 23-10-1996 BR 9608065 A 29-06-1999 CA 2216423 A 10-10-1996 CN 1185116 A 17-06-1998 CZ 9703027 A 11-11-1998 EE 9700250 A 15-04-1998 EP 0820312 A 28-01-1998 HR 960148 A 31-10-1997 HU 9801949 A 01-02-1999 P 11503166 T 23-03-1999 LT 97157 A, B 25-05-1998 LV 12039 A 20-05-1998 LV 12039 B 20-10-1998 NO 974549 A 02-12-1997 NZ 308284 A 28-05-1999 PL 322583 A 02-02-1998 SI 9620044 A, B 30-06-1998 SK 132997 A 11-01-1999 US 6010679 A 04-01-2000 US 5360895 A 01-11-1994 NONE Form PCT/ISA/210 (patent family annex) (July 1992)

Inventors: LIU SHUANG, LIU, SHUANG
Applicants: DU PONT PHARM CO, DUPONT PHARMACEUTICALS COMPANY
Application year: 2001
Main classification: C07F9
IPC codes: A61K51, C07B59, C07F9, C07F13, C07H5, C07H13, C07K5, C07K7