INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS

Abstract: The invention relates to indolyl piperidinyl derivatives of formula (I) wherein: A<1> represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or hydroxyalkylene group; A<2> represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or an alkyleneoxyalkylene group; W<1> represents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; W<2> represents a 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms said group being unsubstituted or substituted by one or more halogen atoms, alkyl groups, alkoxy groups and/or oxo groups; R<1> represents a hydrogen or halogen atom or an alkyl, alkoxy or methylamino group; and R<2> represents a carboxyl group; and pharmaceutically acceptable salts thereof; to processes for their preparation; to pharmaceutical compositions containing them; and to their medical use as antihistaminic and antiallergic agents.

Description: INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS The present invention relates to novel indolylpiperidine compounds and pharmacologically acceptable salts thereof which have antihistaminic and antiallergic activity and are useful as medicaments for the treatment of bronchial asthma, allergic rhinitis, conjunctivitis, dermatosis, urticaria and the like. The present invention also relates to a method for preparing the indolylpiperidine compounds and pharmaceutical compositions useful for the treatment of allergic diseases and bronchial asthma which comprises an effective amount of the indolylpiperidine compound. Several antihistaminic and antiallergic agents containing the indolylpiperidine core are known. Examples of indolylpiperidine compounds represented by the following formula, where R = H, OH, OR' and n = 2-6, are described in Arch . Pharm . 1996 , 329 (1 ) , 3-10. Furthermore, as compounds useful for the treatment of allergic diseases, EP 224919 discloses examples represented by the following formula : • (where R 1 = opt . subst .amino; R 2 = H, lower alkyl or aryl; R 3 = H, N0 2 , opt . subst .amino, OH or lower alkoxy; A = lower alkylene; Q = H or halogen) . Most of these compounds are characterised as antiallergic agents useful for treating allergic asthma, rhinitis, conjunctivitis and urticaria. Current antihistamines cannot be considered to be fully satisfactory from a safety point of view and problems remain with respect to adverse reactions such as sleepiness, sedation, hydrodipsia, mydriasis, palpitation and arrhythmia mediated through their undesirable penetration of the central nervous system, antiacetylcholinergic activity, activity against cardiovascular system and the like. Consequently, the clinical need exists for antihistamines and antiallergic agents which are largely devoid of sedative and cardiovascular side-ef ects. The present invention provides novel indolylpiperidine compounds having improved antihistamine and antiallergic activity. The present invention also provides novel indolylpiperidine compounds which due to their lack of lipophilic properties are almost totally unable to penetrate into the brain and hence lack sedative secondary effects. It can also be understood that the compounds of the present invention have reduced cardiovascular side effects. A further objective of the present invention is to provide a method for preparing said compounds . Yet another objective is to provide a pharmaceutical composition comprising an effective amount of said compounds. In accordance with the present invention, indolylpiperidine compounds represented by the formula (I) are provided: wherein : A 1 represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or hydroxyalkylene group; A^ represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or alkyleneoxyalkylene group; 1 represents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; ^ represents a 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms said group being unsubstituted or substituted by one or more halogen atoms, alkyl groups, alkoxy groups and/or oxo groups ; R 1 represents a hydrogen or halogen atom or an alkyl, alkoxy or methylamino group; and R 2 represents a carboxyl group; and pharmaceutically acceptable salts thereof In the above formula (I) , the alkyl, alkylene, alkyleneoxy, alkylenethio, alkanoylene, hydroxyalkylene and alkoxy groups mentioned in relation to the groups A 1 , A 2 , W 1 , 2 and R 1 in the compounds of the invention, may be branched or straight and preferably contain up to 7 and particularly up to 5 carbon atoms . In the above formula (I), the 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms mentioned in relation to the group 2 may be saturated or unsaturated including aromatic. In the monocyclic or bicyclic groups mentioned in relation to the group W 2 , it will be understood that the 1, 2 or 3 heteroatoms are contained within the cyclic structure. In preferred groups 2 the 1, 2 or 3 heteroatoms are selected from the group consisting of oxygen, sulphur and nitrogen. In the more preferred groups W 2 the monocyclic or bicyclic group has from 5 to 9 members in particular the monocyclic or bicyclic group is a monocyclic group having 5 or β members or a bicyclic group having 9 members . In the above formula (I) , the expression "one or more" defining the number of optional substituents present in the groups W 1 and W 2 means from one to the number of substitutable positions on the chemical moiety being substituted. Preferably, in compounds of the invention wherein the W 1 and/or 2 groups contain substituents, the groups have from 1 - 3 substituents. In the compounds of the invention it is to be understood that the substituents mentioned in relation to the groups W 1 and W 2 may be at any substitutable position or combination of substitutable positions on the chemical moiety being substituted. It will be understood that the phenylene, furanylene or pyridinylene group W 1 may be substituted by A 1 and R 2 at any combination of substitutable ring positions relative to each other, for example 1,2; 1,3; or 1,4. In compounds of the invention wherein the phenylene, furanylene or pyridinylene group 1 is further substituted, the further substituents may be attached at any of the remaining ring positions . In the above formula (I) it will be understood that the substituent R 1 may be attached at the 4, 5, 6 or 7 position of the indolyl nucleus . In preferred compounds of the invention R 1 is attached to the 5 or 6 position of the indolyl nucleus . Further features and advantages of the present invention will become apparent from the description of the preferred compounds which follows, when read in the light of the attached Examples. In preferred compounds of the invention A 1 represents an alkylene or an alkyleneoxy group more preferably a C x _ 3 alkylene such as a methylene, ethylene or propylene group or a C t _ 5 alkyleneoxy group such as a methyleneoxy, ethyleneoxy, propyleneoxy, butyleneoxy or pentyleneoxy group. In preferred compounds of the invention A 2 represents a C 1 . s alkylene, C x _ 5 alkanoylene, C 2 . 5 alkyleneoxy, C 2 _ s alkylenethio or C 2 . s alkyleneoxy-C 1 . s alkylene group. In more preferred compounds of the invention A 2 represents a methylene, ethylene, propylene, butylene, ethanoylene, propanoylene, butanoylene, ethyleneoxy, propyleneoxy, butyleneoxy, ethylenethio, propylenethio, buytylenethio, ethyleneoxyethylene or ethyleneoxymethylene group. In preferred compounds of the invention 1 represents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more, preferably one or two, substituents selected from fluorine, chlorine or bromine atoms and methyl and methoxy groups . More preferably 1 represents an unsubstituted phenylene, furanylene or pyridinylene group or a phenylene group substituted with a fluorine atom, bromine atom or methoxy group. Most preferably 1 represents an unsubstituted phenylene or a phenylene group substituted with a methoxy group. In the preferred compounds of the invention the optionally substituted 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms specified in the definition 2 is a dioxolanyl, dioxanyl, pyrazolidinyl, isoindolinyl, benzodioxolanyl, tetrahydropyranyl , tetrahydrofuranyl, oxetanyl, furanyl , thienyl, pyrrolyl, pyridinyl, imidazolyl, dihydrothiazolyl , benzothiazolyl , pyrrolidinyl, benzooxazolyl , benzothienyl , pyranyl , benzofuranyl , isobenzylfuranyl , chromenyl , pyrazolyl, oxazolyl, isooxazolyl, furazanyl, isochromanyl , chromanyl , pyrrolinyl, imidazolidinyl , imidazolinyl , pyrazolinyl, piperidyl, piperazinyl, indolinyl, morpholinyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolizinyl, isoindolyl, indolyl, indazolyl, quinazolinyl , isoquinazolinyl , quinolyl, phthalazinyl, naphthyridinyl , quinoxalinyl , quinazolinyl or cinnolinyl group. More preferably the optionally substituted 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms is a dioxolanyl, dioxanyl, pyrazolidinyl, isoindolinyl, benzodioxolanyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, furanyl , thienyl, pyrrolyl, pyridinyl, imidazolyl, dihydrothiazolyl, benzothiazolyl, pyrrolidinyl or a benzooxazolyl group. More preferably the optionally substituted 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms is a dioxolanyl, dioxanyl, pyrazolidinyl, benzodioxolanyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, furanyl, thienyl, pyrrolyl, pyridinyl, pyrrolidinyl or a benzooxazolyl group. In compounds of the invention wherein the 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms specified in the definition W 2 is substituted, the one or more substituents are preferably independently selected from fluorine atoms, chlorine atoms, bromine atoms, C x _ 7 alkyl groups, C^, alkoxy groups and oxo groups. Most preferably the substituents are selected from chlorine atoms, C x , 4 alkyl groups, methoxy groups and oxo groups. In particularly preferred compounds of the invention the optionally substituted 3-10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms specified in the definition W 2 is a 5 membered ring containing 1 or 2 heteroatoms and the ring is either unsubstituted or substituted by a C 1 . 7 alkyl group or a chlorine atom. In preferred compounds of the invention R 1 represents a hydrogen, fluorine, chlorine or bromine atom or a methyl, methoxy or methylamino group. Most preferably R 1 represents a hydrogen, a fluorine atom or a methoxy group. More preferred compounds of formula (I) are those in which A 1 represents a methylene, ethylene or ethyleneoxy group; A 2 represents a methylene, ethylene, propylene, butylene, ethyleneoxy, propyleneoxy, ethyleneoxyethylene, ethyleneoxymethylene, ethanoylene, butanoylene or a propylenethio (propylsulfanylene) group; 1 represents an unsubstituted phenylene, furanylene or pyridinylene group or a phenylene group substituted with one or more fluorine, bromine or methoxy groups; 2 represents a (1 , 3 ) -dioxolanyl , (1,3) -dioxanyl, 2,5, 5-trimethyl- [1,3] -dioxan-2-yl , isoindolyl, 1 , 3-dioxo-l, 3-dihydroisoindolinyl , (1,3)- benzodioxolanyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, furanyl , thienyl, 5-chlorothienyl , pyrrolyl, pyridinyl, imidazolyl, methylimidazolyl, dihydrothiazolyl, benzothiazolyl, pyrrolidinyl, pyrrolidinonyl , benzoxazolonyl , phthalimidoyl, benzooxazolyl, 2-oxobenzooxazolyl or 5 -methyl- 2-oxobenzooxazolyl group; R 1 represents a hydrogen, a fluorine atom or a methoxy group, for example a hydrogen atom or a fluorine atom, and R 2 represents a carboxyl group. More preferred compounds of formula -(I) are those in which A 1 represents a- methylene, ethylene or ethyleneoxy group; A 2 represents a methylene, ethylene, propylene, butylene or a ethyleneoxy group; 1 represents an unsubstituted phenylene, furanylene or pyridinylene group or a phenylene group substituted with one or more fluorine, bromine or methoxy groups; 2 represents a (1, 3) -dioxolanyl, (1, 3) -dioxanyl , tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, furanyl , thienyl, 5-chlorothienyl , pyrrolyl or a pyridinyl group; R 1 represents an hydrogen, a fluorine atom or a methoxy group and R 2 represents a carboxyl group. The pharmacologically acceptable salts of the compounds of the present invention represented by formula (I) may be acid addition salts or alkali addition salts. Examples of the acid addition salts include mineral acid addition salts such as, for example, hydrochloride , hydrobromide , hydroiodide, sulfate, nitrate, phosphate, and organic acid addition salts such as, for example, acetate, maleate, fumarate, citrate, oxalate, succinate, tartrate, malate, mandelate, methanesulfonate, and p-toluenesulfonate . Examples of the alkali addition salts include inorganic salts such as, for example sodium, potassium, calcium and ammonium salts and organic alkali salts such as, for example, ethylenediamine, ethanola ine, N, N-dialkylenethanolamine , triethanolamine and basic amino acid salts. The compounds of the present invention represented by the above-described formula (I) may include enantiomers depending on their asymmetry or diastereoisomers. The single isomers and mixtures of the isomers fall within the scope of the present invention. The preferred indolylpiperidine compounds of the present invention include the following compounds: 1. 2-{2- [4- (1- [l,3]dioxolan-2-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid 2. 2- (2- (4- [1- (tetrahydro-pyran-2-ylmethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 3. 2- {2- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) -piperidin-1- yl] -ethoxy} -benzoic acid 4. 2- (2- {4- [1- (3 -pyrrol-1-yl-propyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 5. 2- (2- {4- [1- (3-thiophen-2-yl-propyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 6. 2- [2- (4-{l- [3- (1-methyl-IH-imidazol-2-ylsulfanyl) -propyl] - lH-indol-3-yl}-piperidin-l-yl) -ethoxy] -benzoic acid 7. 2- [2- (4-{l- [2- (2,5,5-trimethyl- [1 , 3] dioxan-2 -yl) -ethyl] - lH-indol-3-yl}-piperidin-l-yl) -ethoxy] -benzoic acid 8. 2- {2- [4- (l-thiophen-2-ylmethyl-lH-indol-3-yl) -piperidin-1- yl] -ethoxy} -benzoic acid 9. 2- {2- [4- (l-furan-2-ylmethyl-lH-indol-3-yl) -piperidin-1- yl] -ethoxy} -benzoic acid 10. 2- (2- {4- [1- (2-oxo-2-pyrrolidin-l-yl-ethyl) -lH-indol-3- yl] -piperidin-1-yl} -ethoxy) -benzoic acid 11. 2-{2- [4- (l-thiophen-3-ylmethyl-lH-indol-3-yl) -piperidin- 1-yl] -ethoxy} -benzoic acid 12. 2- (2- {4- [1- (2-thiophen-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 13. 2- (2- {4- [1- (2-thiophen-3-yl-ethyl) -lH-indol-3 -yl] - piperidin-1-yl} -ethoxy) -benzoic acid 14. 2- [2- (4-{l- [3- (tetrahydro-furan-2-yl) -propyl] -lH-indol-3- yl} -piperidin-1-yl) -ethoxy] -benzoic acid 15. 2-(2-{4-[l-(4- [l,3]dioxolan-2-yl-butyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 16. 2- [2- (4- {l- [3- (benzo [1,3] dioxol-5-yloxy) propyl] -lH-indol- 3-yl}piperidin-l-yl) ethoxy] benzoic acid 17. 2- [2- (4-{l- [3- (l,3-dioxo-l,3-dihydro-isoindol-2-yl) - propyl] -lH-indol-3-yl} -piperidin-1-yl) -ethoxy] -benzoic acid 18. 2- {2- [4- (1-benzo [1, 3]dioxol-5-ylmethyl-lH-indol-3 -yl) - piperidin-1-yl] -ethoxy} -benzoic acid 19. 2- (2-{4- [1- (5-chloro-thiophen-2-ylmethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 20. 2- [2- (4-{l- [4- (5-methyl-2-oxo-benzooxazol-3-yl) -butyl] • lH-indol-3-yl}-piperidin-l-yl) -ethoxy] -benzoic acid 21. 2- (2-{4- [1- (3- [l,3]dioxolan-2-yl-propyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 22. 2- {2- [4- (6-fluoro-l-furaή-2-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid 23. 2- (2-{4- [1- (2- [l,3]dioxolan-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 24. 2- (2-{4- [1- (2- [1 , 3 ] dioxolan-2 -yl-ethyl) -6-fluoro-lH- indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid 25. 3- [4- (l-thiophen-2-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid 26. 3- [4- (l-pyridin-3-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid 27. 3- {4- [1- (5-chloro-thiophen-2 -ylmethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid 28. 3-{4- [1- (2- [1,3] dioxolan-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid 29. 3-{4- [1- (3- [1 , 3] dioxolan-2-yl-propyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid 30. 3- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid 31. 3- (4-{l- [3- (benzo[l,3]dioxol-5-yloxy) -propyl] -lH-indol-3- yl}-piperidin-l-ylmethyl) -benzoic acid 32. 3- [4- (1- [l,3]dioxolan-2-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid 33. 3- [4- (l-pyridin-2-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid 34. 2-methoxy-5- [4- (l-pyridin-3 -ylmethyl-lH-indol-3 -yl) - piperidin-1-ylmethyl] -benzoic acid 35. 5-{4- [1- (2- [1,3] dioxolan-2 -yl-ethyl) -lH-indol-3 -yl] ■ piperidin-1-ylmethyl} -2-methoxy-benzoic acid 36. 5-{4-[l-(3-[l,3] dioxolan-2 -yl-propyl) -lH-indol-3-yl] ■ piperidin-1-ylmethyl} -2-methoxy-benzoic acid 37. 2 -methoxy-5- [4- (l-thiophen-2 -ylmethyl-lH-indol-3 -yl) • piperidin-1-ylmethyl] -benzoic acid 38. 2-methoxy-5- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) • piperidin-1-ylmethyl] -benzoic acid 39. 4-bromo-3- [4- (1- [1 , 3] dioxolan-2 -ylmethyl-lH-indol-3 -yl) • piperidin-1-ylmethyl] -benzoic acid 40. 4-bromo-3- [4- (1-pyridin-3-ylmethyl-lH-indol-3 -yl) ■ piperidin-1-ylmethyl] -benzoic acid 41. 4-bromo-3-{4- [1- (2- [1, 3] dioxolan-2 -yl-ethyl) -lH-indol-3- yl] -piperidin-1-ylmethyl} -benzoic acid 42. 4-bromo-3- {4- [1- (3- [1 , 3] dioxolan-2-yl-propyl) -lH-indol-3- yl] -piperidin-1-ylmethyl} -benzoic acid 43. 4-bromo-3- [4- (l-thiophen-2-ylmethyl-lH-indol-3 -yl) ■ piperidin-1-ylmethyl] -benzoic acid 44. 2-{4- [5-methoxy-l- (2-thiophen-3-yl-ethyl) -lH-indol-3-yl] ■ piperidin-1-ylmethyl} -benzoic acid 45. 3- (4- {l- [3- (benzo [1,3] dioxol-5-yloxy) -propyl] -lH-indol-3- yl} -piperidin-1-ylmethyl) -4-bromo-benzoic acid 46. 2-fluoro-5- [4- (1-pyridin-3 -ylmethyl-lH-indol-3 -yl) • piperidin-1-ylmethyl] -benzoic acid 47. 5-{4- [1- (2- [1 , 3] dioxolan-2 -yl-ethyl) -lH-indol-3-yl] ■ piperidin-1-ylmethyl} -2-fluoro-benzoic acid 48. 5- {4- [1- (3- [1,3] dioxolan-2-yl-propyl) -lH-indol-3-yl] ■ piperidin-1-ylmethyl } -2-fluoro-benzoic acid 49. 2-fluoro-5- [4- (1-pyridin-4-ylmethyl-lH-indol-3 -yl) ■ piperidin-1-ylmethyl] -benzoic acid 50. 5- (4- {l- [3- (benzo [1, 3] dioxol-5-yloxy) -propyl] -lH-indol-3- yl} -piperidin-1-ylmethyl) -2-fluoro-benzoic acid 51. 5-[4-(l- [1,3] dioxolan-2 -ylmethyl-lH-indol-3 -yl) - piperidin-1-ylmethyl] -2-fluoro-benzoic acid 52. 2-fluoro-5- [4- (1-pyridin-2 -ylmethyl-lH-indol-3 -yl) - piperidin-1-ylmethyl] -benzoic acid 53. 2- (2- {4- [1- (tetrahydro-furan-3 -ylmethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 54. 2- (2-{4- [1- (2-morpholin-4-yl-ethyl) -lH-indol-3 -yl] - piperidin-1-yl} -ethoxy) -benzoic acid 55. 2- (2- (4- [1- (3 -methyl-oxetan-3 -ylmethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 56. 2- {2- [4- (l-furan-3 -ylmethyl- lH-indol -3 -yl) -piperidin-1- yl] -ethoxy} -benzoic acid 57. 2- (2- {4- [1- (2-pyridin-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1 -yl} -ethoxy) -benzoic acid 58. 3- {4- [1- (tetrahydro-furan-3 -ylmethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl } -benzoic acid 59. 3-{4- [1- (3 -methyl-oxetan-3 -ylmethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl } -benzoic acid 60. 3- {4- [1- (2 -thiophen-3 -yl-ethyl) -lH-indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid 61. 3- [4- (l-furan-3-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid 62. 2- [4- (l-pyridin-3-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -nicotinic acid 63. 2- {4- [1- (2-morpholin-4-yl-ethyl) -lH-indol-3-yl] - piperidin- 1 -ylmethyl } -nicotinic acid 64. 2- [4- (l-thiophen-2-ylmethyl-lH-indol-3-yl) -piperidin-1- yl ethyl] -nicotinic acid 65. 3- {4- [1- (5-chloro-thiophen-2-ylmethyl) -6-fluoro-lH-indol- 3-yl] -piperidin-1-ylmethyl} -benzoic acid 66 . 3- (4- [6-fluoro-l- (2-thiophen-3-yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl } -benzoic acid 67. 3-{4- [6-fluoro-l- (2 -thiophen-2 -yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid 68. 2-methoxy-5-{4- [1- (2 -thiophen-2 -yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid 69 . 5-{4- [6-fluoro-l- (2-thiophen-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -2-methoxy-benzoic acid 70. 5- {4- [6-fluoro-l- (2 -morpholin-4 -yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -2-methoxy-benzoic acid 71. 5- {4- [1- (2- [l,4]dioxan-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -2-methoxy-benzoic acid • 72. 3-{4- [1- (2- [l,4]dioxan-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid 73. 2 -methoxy-5- [4- (1-thiophen-2 -ylmethyl-lH-indol-3 -yl) - piperidin- 1-ylmethyl] -benzoic acid 74. 4-bromo-3- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) - piperidin- 1-ylmethyl] -benzoic acid 75. 2-methoxy-5-{4- [1- (2-thiophen-3-yl-ethyl) -lH-indol-3-yl] - piperidin- 1-ylmethyl} -benzoic acid 76. 3- (4- [1- (2-morpholin-4-yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid 77. 2- [2- (4- {l- [2- (benzo [1 , 3] dioxol-5-yloxy) -ethyl] -lH-indol- 3-yl} -piperidin-1-yl) -ethoxy] -benzoic acid 78. 5-{4- [6-fluoro-l- (2 -thiophen-3 -yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -2-methoxy-benzoic acid 79. 5- {4- [1- (5-chloro-thiophen-2-ylmethyl) -6-fluoro-lH-indol- 3-yl] -piperidin-1-ylmethyl} -2-methoxy-benzoic acid 80. 5- [4- (6-fluoro-l-furan-3-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid 81. 3- {4- [1- (2-pyridin-2-yl-ethyl) -lH-indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid 82. 5- [4- (6-fluoro-l-thiophen-2-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid 83. 3- [4- (l-furan-2-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid 84. 2- (2-{4- [1- (2- [l,4]dioxan-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid 85. 5- [4- (l-furan-2-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -2-methoxy-benzoic acid 86. 5- [4- (l-furan-3 -ylmethyl- lH-indol-3 -yl) -piperidin-1- ylmethyl] -2-methoxy-benzoic acid 87. 3- {4- [5-methoxy-l- (2-thiophen-3 -yl-ethyl) -lH-indol-3-yl] • piperidin-1-ylmethyl} -benzoic acid 88. 2- (2- {4- [5-methoxy-l- (2-thiophen-3 -yl-ethyl) -lH-indol-3- yl] -piperidin-1-yl} -ethoxy) -benzoic acid 89. 2-{2-[4- (5 -methoxy-1-thiophen-2 -ylmethyl-lH-indol-3 -yl) - piperidin-1-yl] -ethoxy} -benzoic acid 90. 3- [4- (5 -methoxy-1-thiophen-2 -ylmethyl-IH-indol-3 -yl) - piperidin- 1-ylmethyl] -benzoic acid 91. 2-methoxy-5- {4- [5-methoxy-l- (2-thiophen-3-yl-ethyl) -IH- indol-3 -yl] -piperidin-1-ylmethyl} -benzoic acid 92. 2- {2- [4- (l-furan-3 -ylmethyl -5 -methoxy-lH-indol-3 -yl) - piperidin- 1-yl] -ethoxy} -benzoic acid 93. 3- [4- (l-furan-3 -ylmethyl-5 -methoxy-lH-indol-3 -yl) - piperidin- 1-ylmethyl] -benzoic acid 94. 2- [4- ( 1-furan-2 -ylmethyl -lH-indol-3 -yl) -piperidin-1- ylmethyl] -benzoic acid 95. 2- [4- (6-fluoro-l-furan-2-ylmethyl-lH-indol-3-yl) - piperidin- 1-ylmethyl] -benzoic acid 96. 3- [4- ( 6-fluoro-1-furan-2 -ylmethyl-IH-indol -3 -yl) - piperidin-1-ylmethyl] -benzoic acid 97. 5- [4- (6-fluoro-l-furan-2-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid 98. 4-methoxy-2- [4- (5 -methoxy-1-thiophen-2 -ylmethyl-IH-indol- 3-yl) -piperidin-1-ylmethyl] -benzoic acid 99. 2- [4- (5-methoxy-1-thiophen-2 -ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid 100. 2-methoxy-5- [4- (5-methoxy-l-thiophen-2-ylmethyl-lH- indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid 101. 2- [4- ( 1-furan-2 -ylmethyl -5-methoxy-lH-indol-3-yl) - piperidin-1-ylmethyl] -4-methoxy-benzoic acid 102. 3- [4- ( 1-furan-2 -ylmethyl -5-methoxy-lH-indol-3-yl) - piperidin- 1-ylmethyl] -benzoic acid 103. 2- [4- (1-f ran-2 -ylmethyl -5-methoxy-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid 104. 5- [4- (l-furan-2-ylmethyl-5-methoxy-lH-indol-3-yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid 105. 2- (2- [4- (l-furan-2-ylmethyl-5-methoxy-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid 106. 4-methoxy-2- {4- [5-methoxy-l- (2 -thiophen-3 -yl-ethyl) -1H- indol-3 -yl] -piperidin-1-ylmethyl } -benzoic acid 107. 2- {2- [4- (6-fluoro-l-thiophen-2-ylmethyl-IH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid 108. 5- [4- (6-fluoro-l-thiophen-3-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid 109. 2-{2- [4- (6-fluoro-l-thiophen-3-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid 110. 2- (2-{4- [6-fluoro-l- (2 -thiophen-3 -yl-ethyl) -lH-indol-3- yl] -piperidin-1-yl} -ethoxy) -benzoic acid 111. 2- (2- {4- [1- (5-chloro-thiophen-2-ylmethyl) -6-fluoro-lH- indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid 112. 2- {2- [4- (6-fluoro-l-furan-3-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid 113. 2- {2- [4- (5-methoxy-1-thiophen-3-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid 114. 3- [4- (5-methoxy-l-thiophen-3-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid 115. 2- (2- {4- [1- (5-chloro-thiophen-2-ylmethyl) -5-methoxy-1H- indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid 116. 3- {4- [1- (5-chloro-thiophen-2-ylmethyl) -5-methoxy-1H- indol-3-yl] -piperidin-1-ylmethyl} -benzoic acid 117. 2-methoxy-5- [4- (1-thiophen-3 -ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid 118. 3- [4- (l-thiophen-3-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid 119. 5- {4- [1- (5-chloro-thiophen-2-ylmethyl) -5-methoxy-1H- indol-3-yl] -piperidin-1-ylmethyl } -2-methoxy-benzoic acid 120. 3- {4- [5-methoxy-l- (2 -thiophen-2-yl-ethyl) -lH-indol-3- yl] -piperidin-1-ylmethyl} -benzoic acid 121. 2-methoxy-5-{4- [5-methoxy-l- (2-thiophen-2-yl-ethyl) -1H- indol-3-yl] -piperidin-1-ylmethyl} -benzoic acid In accordance with another embodiment of the present invention, it provides a process for preparing a compound represented by formula (I) , comprising the hydrolysis of a compound of formula (VI) wherein A 1 , A 2 , W 1 , W 2 and R 1 are as defined above and R 3 is a -COOR 4 group wherein R 4 represents a C 1 -C 4 alkyl group. The novel indolylpiperidine compounds of the present invention represented by formula (I) can and preferably are prepared according to Scheme 1. Scheme 1 The piperidine derivative of general structure (II) wherein R 1 is as defined above, is alkylated with a reactive intermediate of general formula (III) : X-A'- ^R 3 (III) wherein A 1 and 1 are as defined above, R 3 is a -COOR 4 group where R 4 is a C x -C 4 alkyl group and X is a leaving group such as a chlorine or bromine atom, or a methane sulfonate, p- toluene sulfonate or benzene sulfonate group. The reaction is preferably carried out in an inert organic solvent such as toluene, dioxane or methyl isobutyl ketone, at a temperature between 80°C and 140 °C and in the presence of an inorganic base such as an alkali metal carbonate or bicarbonate . In the reaction, the corresponding alkylation product of general formula (IV) is formed: Compound (IV) is alkylated on the indole nitrogen with a reactive intermediate of general formula (V) : X-A-W 2 (V) wherein X is a leaving group such as a chlorine or bromine atom, or a methane sulfonate, p-toluene sulfonate or benzene sulfonate group and A 2 and W 2 are as defined above. The reaction is preferably carried out in an inert organic solvent such as dimethylformamide, tetrahydrofuran or ethyl ether, at a temperature between 0°C and 80 °C in the presence of an inorganic base such as sodium hydride or sodium amide. In the reaction, the corresponding alkylation product of general formula (VI) is formed wherein R 1 , R 3 , 2 , A 1 and A 2 are as defined above. Usually, an excess of the reagents is employed in both alkylations to ensure complete reaction. In such cases, a polymer, such as methyl isocyanate polystyrene or/and 3- (3- mercaptophenyl) -propanamidomethyl polystyrene may be conveniently added to react with the excess reagent. Isolation of the products from reactions where a polymer bound reagent has been used is greatly simplified, requiring only filtration under reduced pressure. The product from these reactions may be purified by solid phase extraction, using a suitable sorbent, such as Varian SCX, or Varian C18. Following a different pathway (see Scheme 1) , the piperidine of compound (II) is protected at its reactive piperidine nitrogen atom by a suitable protecting group such as by forming a carba ate moiety (the ethylcarbamate is shown by way of example) to give compounds of general structure (VII) wherein R 1 is as defined above. This reaction is preferably carried out in methylenechloride or chloroform as a solvent in the presence of triethylamine and ethyl chloroformate at a temperature between -20 °C and 30 C C. Compound (VII) is alkylated on the indole with a reactive intermediate of general formula (V) : X-A 2 - 2 (V) wherein X is a leaving group such as a chlorine or bromine atom, or a methane sulfonate, p-toluene sulfonate or benzene sulfonate group and A 2 and 2 are as defined above. This reaction is preferably carried out in an inert organic solvent such as dimethylformamide, tetrahydrofuran or ethyl ether, at a temperature between 0°C and 80 °C in the presence of an inorganic base such as sodium hydride or sodium amide. In the reaction, the corresponding alkylation product of general formula (VIII) is formed wherein R 1 , 2 and A 2 are as defined above. Compound (VIII) is deprotected in the appropriate manner for the protecting group selected in the previous step. For the exemplified carbamate group this can be by boiling in the presence of an excess of sodium or potassium hydroxide in an alcoholic solvent such as ethanol, isopropanol or n-butanol at a temperature between 80°C and 180°C. Further neutralisation with an inorganic acid such as hydrochloric or sulfuric acid, leads to a compound of general structure (IX) wherein R 1 , A 2 and W 2 are as defined above. Further alkylation of compound (IX) with a reactive intermediate of general formula (III) gives a compound of general structure (VI) X - A 1 - W 1 - R 3 ( II) wherein R 1 , A 1 , A 2 , W 1 and W 2 are as defined above, R 3 a -COOR 4 group where R 4 is a C^^ alkyl group and X is a leaving group such as a chlorine or bromine atom, or a methane sulfonate, p- oluene sulfonate or benzene sulfonate group. The reaction is preferably carried out in an inert organic solvent such as toluene, dioxane or methyl isobutyl ketone, at a temperature between 80 °C and 140 α C in the presence of an inorganic base such as an alkali metal carbonate or bicarbonate. Compounds of general formula (VI) where R 3 represents an alkyl ester are treated with sodium or potassium hydroxide and further neutralisation with an inorganic acid such as hydrochloric or sulfuric acid provides the corresponding indole derivative of formula (I) where R 2 is a carboxylic acid. The reaction is preferably carried out in a solvent such as methanol, ethanol, tetrahydrofuran or an aqueous mixture of one of the above mentioned solvents at its boiling point . Occasionally, the compounds of the present invention are purified by preparative HPLC-MS. In these cases, a Gilson- Termoquest HPLC-MS is used with C-18 preparative columns (5μm, 1x5 cm, Waters) and using water/formic acid 0.1% as mobile phase. The piperidine derivatives of formula (II) can be prepared from the 4-piperidone as disclosed in the literature (J. Med . Chem. 1992, 35, 4813-4822) . The reactive intermediates of general formula (III) are either commercially available or they can be prepared as disclosed in the literature or their preparation is included in the present invention. Also included within the scope of the present invention are pharmaceutical compositions which comprise, as the active ingredient, at least one indolylpiperidine derivative of general formula (I) , or a pharmacologically-acceptable salt thereof, in association with a pharmaceutically-acceptable carrier or diluent. Preferably the composition is made up in a form suitable for oral, or parenteral administration. The pharmaceutically-acceptable carriers or diluents which are mixed with the active compound or compounds, or salts thereof, to form the composition of this invention are well-known "per se" and the actual excipients used depend "inter alia" on the intended method of administration of the compositions. Compositions of this invention are preferably adapted for oral administration. In this case, the composition for oral administration may take the form of tablets, capsules or effervescent granules or liquid preparations such as elixirs, syrups or suspensions, all containing one or more compounds of the invention; such preparations may be made by methods well known in the art. The diluents which may be used in the preparations of the compositions include those liquid and solid diluents which the active ingredient is mixed together with colouring or flavouring agents, if desired. Tablets or capsules may conveniently contain between 0.2 and 500 mg, preferably from 0.5 to 100 mg, of active ingredient or the equivalent amount of a pharmacologically-acceptable salt thereof. The compounds may be incorporated into pellets coated with an appropriate natural or synthetic polymers known in the art to produce sustained release characteristics or incorporated with polymers into tablet form to produce the same characteristics . The liquid composition adapted for oral use may be in the form of solution or suspension. The solution may be an aqueous solution of an acid addition salt of the indolylpiperidine derivative in association with, for example, sucrose or sorbitol to form a syrup. The suspension may comprise an insoluble or micro encapsulated form of an active compound of the invention in association with water of other pharmaceutically-acceptable liquid medium together with a suspending agent or flavouring agent . Composition for parenteral injection may be prepared from soluble salts of the indolylpiperidine derivative, which may or may not be freeze-dried and which may be dissolved in water or an appropriate parenteral injectable fluid. In human therapy, the doses of the compound of general formula (I) depend on the desired effect and duration of treatment; adult doses are generally between 0.2 mg and 500 mg per day and preferably between 0.5 mg and 100 mg per day. In general, the physician will decide the dosing regime taking into account the age and weight of the patient being treated. Pharmacological Action The following examples demonstrate the excellent pharmacological activities of the compounds of the present invention. The results of (1) Histamine-H j^ receptor binding assay, (2) Histamine-induced skin vascular permeability in rats with the monitoring of antiallergic activity, (3) H x ex vivo binding studies in mice with the monitoring of degree of penetration into brain and (4) measurement of blood pressure and heart rate in conscious unrestrained hypertensive rats with the monitoring of cardiovascular effects, were obtained as described below. (1) Histamine-H 1 receptor binding assay Binding to the histamine-H- L receptors was performed in guinea pig cerebellum membranes as described previously (Chang et al . , 1979). Briefly, the membrane suspensions (160μg/ml) were incubated at 30 °C with 0.7 nM [ 3 H] - mepyramine and different concentrations of the test compounds in a final volume of 250 μl . Binding reactions were terminated by filtration after 30 min of incubation and the bound radioactivity was determined. The specific binding was measured in the presence of 10 μM of promethazine . The affinity of each test compound to the receptor was determined by using at least six different concentrations run in duplicate. IC S0 values were obtained by non-linear regression by use of SAS on a DEC AXP computer. Table 1. Histamine-H j _ receptor binding assay Our results show that the compounds of the present invention have affinities for the Hi receptors very similar to the reference compounds. (2) Histamine- induced skin vascular permeability in rats Male Wistar rats (180-210 g) were treated orally with the test compound or vehicle. 1, 4, 8 and 24 hours later, the rats were lightly anaesthetized with ether. The cutaneous reaction was induced by two intradermal injections of 50 μl of histamine (100 μg/ml) onto the back, followed by a intravenous injection of 3 ml/kg of Evan's Blue (5 mg/ml) , both dissolved in saline. Sixty min later, the rats were killed by cervical dislocation and the back skin dissected free. The diameter (in millimetres) of the papule was measured in two directions and the area was calculated. Results are given as the % of inhibition at a given dose compared with the vehicle treated group. The compounds disclosed in examples 22, 23, 24, 73, 75, 78, 79, 80, 82, 85 and 86 show an inhibition > 50% of the of the histamine induced skin vascular permeablity at the dose of 1 mg/Kg 4 hours after administration. In the same experimental conditions, cetirizine shows an inhibition of 7% ' whereas fexofenadine shows a negligible inhibition. (3) H x ex vivo binding studies in mice The assay was performed essentially as described by Leysen et al . , with the following modifications. Overnight starved male Swiss albino mice (21+2 g) were treated orally with different doses of the test compounds (10 ml/kg, p.o.) and 90 minutes later were killed. The whole brain was dissected out and homogenized in 10 ml of ice-cold 0.05 M Na + /K + phosphate buffer (pH 7.4) . A 1 ml aliquot of the homogenate was incubated, in triplicate, with 0.1 ml [ 3 H] -mepyramine (2 nM final concentration, 27 Ci/mmol, Amersham) during 40 minutes at 30 °C. The [ 3 H] -mepyramine bound to the membranes was determined by immediate filtration of the homogenates under vacuum onto the glass fibre filters (Whatman GF/B) followed by three rapid rinses with 5 ml of cold buffer containing lOμM cold mepyramine. The radioactivity bound in the filters was determined by liquid scintillation spectrometry . The non-specific binding was determined by treating the animals with 30 mg/kg p.o. D-chlorpheniramine maleate. Mice treated with vehicle (methylcellulose 0.5% and tween 0.1%) were used to determine the total binding. Results are expressed as the % of specific binding at a given dose of the test compound. The compounds of the present invention display little or no penetration through the blood brain barrier. (4) Measurement of blood pressure and heart rate in conscious unrestrained hypertensive rats Adult male spontaneously hypertensive rats (SHR) were operated upon in order to implant blood pressure sensors in the abdominal aorta just above the iliac bifurcation. After recovery from anaesthesia, rats were housed individually in cages placed on radio-frequency receivers. Amoxycillin (15 mg/kg, i.m., after surgery) was administered to prevent infection. The rats were allowed to recover for at least 2 weeks after transmitter implantation. Arterial blood pressure and heart rate were recorded and analysed by Dataquest V system (Data Science, St. Paul, MN) . The animals were kept on a 12:12 hours light-dark cycle during the entire recording period. After 18 hours of fasting with water "ad libitum", the animals received drugs orally and were then given food. Hemodynamic recordings were taken every 15 minutes, starting 4 hours before drug administration and continuing up to 24 hours after. Each recording lasted 10 seconds, and the hemodynamic values of all cycles within this period were averaged. All the animals received all the treatments, between administrations in the same rat, there was a seven day wash-out period, and a complete recovery to base-line values was ascertained. The effects of treatments on mean arterial blood pressure and heart rate were determined with one-way analysis of variance (ANOVA). A P value < 0.05 was considered statistically significant. The compounds of the present invention have little or no effects on blood pressure and heart rate at doses from 3 to 30 mg/kg. From the above described results it will be understood that that the compounds of the present invention have excellent antihistamine and antiallergic activities. Compounds of the present invention have reduced cardiovascular and central nervous system side effects and are thus useful for the treatment of various allergic disorders, for instance, bronchial asthma, rhinitis, conjunctivitis, dermatitis and urticaria. The invention thus provides a method for treating an allergic disorder for instance, bronchial asthma, rhinitis, conjunctivitis, dermatitis and urticaria comprising the step of administering to a human or animal patient in need of such treatment an effective amount of a compound of formula (I) . The invention also provides the use of the compounds of formula (I) in the manufacture of a medicament for the treatment of an allergic disorder for instance, bronchial asthma, rhinitis, conjunctivitis, dermatitis and urticaria. The present invention will be further illustrated by the following Examples. These Examples are given by way of illustration only and are not to be construed as limiting. Table 2. List of Examples T e sign (* in the struc ures shows only t e inding point ut it oes not symbolise a carbon atom. Example 1. Preparation of 2 - {2 - [4 - ( 1- [1, 3 ] dioxolan- 2 -ylmethyl -lH- indol- 3 -yl) -piperidin-1-yl] -ethoxy} -benzoic acid A. Preparation of 3 - ( 1 , 2 , 3 , 6 - etrahydro-pyridin-4 -yl) -1H- indole 30 g (0.26 mol) of indole was dissolved in a solution of potassium hydroxide (77.6 g, 1.38 mol) in methanol (692 ml) . 4-piperidone monohydrate hydrochloride (102.3 g, 0.66 mol) was added in one portion and the mixture was heated to reflux for 5 h. Potassium chloride precipitated upon cooling at room temperature and it was filtered off. The liquid phase was concentrated until only one third of the liquid remained in the round-bottom flask. The solid formed during the concentration of the liquid phase was filtered and washed thoroughly with ethanol and, finally, with ethyl ether. 31.9 g (63% of yield) of the final product were obtained. Melting point = 183-185°C. B. Preparation of 3-piperidin-4-yl-lH-indole 19.03 g (0.096 mol) of 3- (1 , 2 , 3 , 6-tetrahydro-pyridin-4-yl) -1H-indole were hydrogenated in a Parr apparatus during 18 h at 40 psi with 2.2 g of Pd/C 10% in 600 ml of methanol. After standard work-up, 16.76 g (87% of yield) of the desired product were obtained. Melting point = 210-212°C. C. Preparation of 2- (2 -chloro-ethoxy) -benzoic acid methyl ester 34 g (0.25 mol) of potassium carbonate were added to a solution of 25 g (0.16 mol) of methyl salicylate in 250 ml of methyl ethyl ketone. This mixture was refluxed for 1 h, then 27.3 ml (0.35 mol) of l-bromo-2-chloro-ethane were added and the mixture was taken to reflux again. Four hours later, 34 g (0.25 mol) more of potassium carbonate and 16.3 ml (0.2 mol) more of l-bromo-2-chloro-ethane were added. This operation was repeated until the reaction was completed. The inorganic salts were filtered off and the liquid phase was diluted with the same volume of hexane. This organic phase was washed twice with water and worked-up as usual . The yield in this step was quantitative and the product was pure enough for the next synthetic step. NMR (300 MHz, CDC1 3 ) 5=3.86-3.90 (m, 5H) , 4.28-4.33 (t, 2H) , 6.96-7.09 (m, 2H) , 7.43-7.51 (m, 1H) , 7.78-7.83 (m, 1H) . D. Preparation of 2-{2- [4- (lH-indol-3 -yl) -piperidin-1-yl] - ethoxy} -benzoic acid methyl ester 0.14 g (0.65 mmol) of 2- (2 -chloro-ethoxy) -benzoic acid methyl ester were added to a mixture of 0.1 g (0.5 mmol) of 3-piperidin-4-yl-lH-indole, 0.10 g (0.75 mmol) of potassium carbonate and 0.06 g (0.37 mmol) of potassium iodide in 1.5 mL of isobutyl methyl ketone under nitrogen atmosphere and the reaction mixture was refluxed for 18 hours. After cooling at room temperature, 1.5 mL of dichloromethane and 0.08 g (0.1 mmol) of polystyrene methyl isocyanate were added and the mixture was stirred at this temperature for 3 hours. After filtering, the solution was placed directly onto a 500 mg Varian SCX ion exchange column. The columns were washed with 5 mL of methanol and the product was eluted with 5 mL of methanol/ammonia 20:1 affording, after removal of the solvent at reduced pressure, 0.113 g (60% yield) of 2- {2- [4- (lH-indol -3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid methyl ester as a yellow oil . ESI/MS m/e = 379 [(M+l) + , C23 H26 N2 033 E. Preparation 2-{2- [4- (1- [1, 3] dioxolan-2 -yl ethyl-lH-indol- 3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid 0.02 g (0.42 mmol) of a dispersion of 60% NaH in mineral oil were added to a solution of 0.06 g (0.16 mmol) of 2- {2- [4- (lH-indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid methyl ester prepared in step D in 1 mL of anhydrous DMF under an inert atmosphere. After stirring 30 minutes at room temperature, 0.04 mg (0.24 mmol) of 2-bromomethyl- [1, 3] dioxolane were added and the mixture was stirred for 18 hours. The solvent was removed under reduced pressure and the crude mixture was dissolved in 1 mL of ethanol. 0.1 mL of 2N NaOH were added and the mixture was stirred at 60 °C for 3 hours . 0.1 mL of 2N HCl were added and the reaction mixture was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure and the crude mixture was purified using a 500 mg Varian C18 chromatography column, affording 0.040 g (56% yield) of 2- {2- [4- (1- [1 , 3] dioxolan-2- ylmethyl-IH-indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid. Melting point 139-141°C NMR (300 MHz, DMSO) 5=1.90-2.10 (m, 4H) , 2.58-2.72 (m, 2H) , 2.90-2.98 (m, 3H) , 3.20-3.24 (m, 2H) , 3.76-3.80 (m, 4H) , 4.25-4.27 ( , 2H) , 4.41-4.45 (m, 2H) , 5.09-5.13 (m, 1H) , 7.00-7.12 (m, 2H) , 7.12 (s, 2H) , 7.38-7.54 (m, 4H) , 7.63-7.65 (d, 1H) . Examples 2-10, 17 and 20 These examples were prepared following the procedure described in Example 1 (parts D and E) . The ESI/MS data and yields are summarised in table 3. Table 3. Examples 2-10, 17 and 20 Example 13 Preparation of 2- (2-{4- [1- (2 -thiophen-3 -yl-ethyl) -IH-indol-3- yl] -piperidin-1-yl} -ethoxy) -benzoic acid A. Preparation of 4- (IH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester To a suspension of 30 g (0.15 mol) of 3 -piperidin-4-yl-lH- indole and 28 mL (0.2 mol) in 185 mL of anhydrous dichloromethane, 17 mL (0.18 mol) of ethyl chloroformate was added dropwise keeping the temperature of the reaction below 20 °C. After 2h at room temperature, the crude mixture was poured into 100 mL of water. The organic layer was separated and dried with sodium sulfate. After filtration, the solvent was removed under reduced pressure affording 39 g (95% of yield) of the expected produc . ESI/MS m/e = 272 [(M+l)\ C16 H20 N2 02] NMR (300 MHz, DMSO) 5=1.16-1.23 (t, 2H) 1.41-1.65 (m, 2H) , 1.92-1.99 (m, 2H) , 2.90-23.10 (m, 3H) 3.99-4.10 ( , 4H) , 6.95-7.10 (m, 3H) , 7.31-7.34 (d, 1H) , 7.53-7.57 (d, 1H) , 10.81 (s, 1H) . B. Preparation of 4- [1- (2-thiophen-3-yl-ethyl) -lH-indol-3- yl] -piperidine-1-carboxylic acid ethyl ester Under inert atmosphere, a solution of 6.9 g (0.025 mol) of 4- (lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester in 25 mL of anhydrous DMF was added dropwise to a suspension containing 1.2 g (0.030 mol) of sodium hydride (60% in mineral oil) in 70 mL of anhydrous DMF. After stirring at room temperature for 1 hour, a solution of 6.2 g (0.03 mol) of 2 -thiophen-3 -yl-ethyl methansulfonate in 15 mL of anhydrous DMF was added. The reaction mixture was stirred at room temperature for 30 minutes and then heated at 60° for 3 hours . The crude mixture was poured into water and extracted with dichloromethane. After drying, the solvent was removed under reduced pressure and 10.3 g of a crude oil were obtained. The crude mixture was purified by flash chromatography over silica gel affording 8.3 g (86% of yield) of the expected product . C. Preparation of 3-piperidin-4-yl-l- (2-thiophen-3 -yl-ethyl) - 1H-indole To a solution of 12.7 g (0.033 mol) of 4- [1- (2-thiophen-3-yl- ethyl) -lH-indol-3-yl] -piperidine-1-carboxylic acid ethyl ester in 10 mL of iso-propanol , a solution of 22 g of potassium hydroxide in 220 mL of iso-propanol was added. The crude mixture was refluxed for 16 hours. After cooling at room temperature, the solvent was removed at reduced pressure and the crude mixture was extracted between toluene and water. The organic layer was dried with sodium sulfate and after filtration, the solvent was removed under reduced pressure affording 9.3g (90% of yield) of an oil which corresponds to the expected product . D. Preparation of 2- (2-{4- [1- (2 -thiophen-3 -yl-ethyl) -1H- indol-3-yl] -piperidin- 1-yl} -ethoxy) -benzoic acid A solution of 1.5 g (0.007 mol) of 2- (2 -chloro-ethoxy) - benzoic acid methyl ester (prepared in Example 1, part C) in 5 mL of methyl-isσ-butylketone was added to a suspension of 2 g (0.065 mol) of 3 -piperidin-4-yl-l- (2 -thiophen-3 -yl-ethyl) - lH-indole and 1.8 g (0.013 mol) of potassium carbonate in 45 mL of methyl-iso-butylketone . The reaction mixture was refluxed for 18 h. The crude mixture was filtered to remove inorganic salts and the solvent was removed under reduced pressure affording 3.3 g of a crude oil. The crude mixture was purified by flash chromatography over silica gel affording 1.5 g (48% of yield) of 2- (2- {4- [1- (2 -thiophen-3 - yl-ethyl) -lH-indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid methyl ester. This ester was dissolved in a mixture of 25 mL of methanol/THF 3:2 and hydrolysed with 2N NaOH at room temperature for 16 hours. The crude mixture was neutralised with 2N HCl aqueous solution and the solvent was removed under reduced pressure. The crude residue was precipitated with dichloromethane and then recrystallised with methanol affording 1.3 g of the expected acid. Melting point 165-167°C NMR (300 MHz, DMSO) 5= 1.75-2.07 (m, 4H) 2.54-2.65 (m, 2H) , 2.77-3.00 (m, 3H) , 3.00-3.13 (t, 2H) , 3.14-3.30 (m, 2H) , 4.25-4.39 (t, 2H) , 4.39-4.55 (m, 2H) , 5.20-5.40 (m, 1H) , 6.93-7.29 (m, 7H) , 7.33-7.59 (m, 4H) , 7.59-7.67 (d, 1H) Examples 11,12,14,15, and 18 These examples were prepared following the procedure described in Example 13 using the suitable methansulfonate or bromide in part B. The ESI/MS data and yields are summarised in table 4. Example 16 Preparation of 2- [2- (4-{l- [3- (benzo [1, 3] dioxol-5- yloxy)propyl] -IH-indol -3 -yl}piperidin-l-yl) ethoxy] benzoic acid A. Preparation of 4-{l- [3 - (benzo [1, 3] dioxol-5-yloxy) -propyl] - lH-indol-3-yl}-piperidine-l-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 2.2 g (8.1 mmol) of 4- (lH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester and 2.68 g (10 mmol) of 5- (3-bromo-propoxy) -benzo [1, 3] dioxole . After standard work-up, 3.8 g (100% of yield) of the expected product was obtained. B. Preparation of 1- [3- (benzo [1, 3] dioxol-5-yloxy) -propyl] -3 - piperidin-4-yl- 1H- indole This compound was prepared following the procedure described in example 13 (part C) starting with 2.68 g (8.1 mmol) of 4- {l- [3- (benzo [1,3] dioxol-5-yloxy) -propyl] -lH-indol-3-yl} - piperidine-1-carboxylic acid ethyl ester. C. Preparation of 2- [2- (4-{l- [3 - (benzo [1, 3] dioxol-5- yloxy)propyl] -lH-indol-3 -yl}piperidin-l-yl) ethoxy] benzoic acid This compound was prepared following the procedure described in example 13 (part D) , starting with 8.1 mmol of 1- [3- (benzo [1, 3] dioxol-5-yloxy) -propyl] -3-piperidin-4-yl-lH-indole and 2.3 g (11 mmol) of of 2- (2-chloro-ethoxy) -benzoic acid methyl ester. After the standard work-up, 2.68 g of the corresponding acid was obtained. The crude mixture was purified by flash chromatography over silica gel affording 1.15 g (26% of yield) of the expected acid. Melting point 147-152°C NMR (300 MHz, DMSO) 5= 1.70-2.00 (m, 4H) , 2.07-2.16 (m, 2H) , 2.60-2.68 (m, 2H) , 2.81-2.97 (m, 3H) , 3.16-3.24 (m, 2H) , 3.76-3.82 (m, 2H) , 4.25-4.30 (t, 2H) , 4.31-4.35 (m, 2H) , 4.30-4.70 (m, 1H) , 5.94 (a, 2H) , 6.32-6.36 (dd, 1H) , 6.62- 6.63 (m, 1H) , 6.78-6.80 (d, 1H) , 6.96-7.13 (m, 4H) , 7.21-7.24 (m, 1H) , 7.36-7.40 (m, 2H) , 7.51-7.54 (m, 1H) , 7.63-7.66 (d, 1H) . 5. Example 19 Preparation of 2- (2-{4- [1- (5-chloro-thiophen-2-ylmethyl) -1H- indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid A. Preparation of 4- [1- (5-chloro-thiophen-2 -ylmethyl) -1H- indol-3-yl] -piperidine-1-carboxylic acid ethyl ester 0 This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 3.5 g (13 mmol) of 4- (lH-indol-3 -yl) - piperidine- 1 -carboxylic acid ethyl ester and 1.9 mL (16 mmol) of 2-chloro-5-chloromethyl-thiophene . After standard work-up, 5 5.2 g * (99% of yield) of the. expected product was obtained. ' B. Preparation of 1- (5-chloro- hiophen-2 -ylmethyl) -3- piperidin-4-yl-lH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 5.21 g (13 mmol) of 4- 0 [1- (5-chloro-thiophen-2-ylmethyl) -lH-indol-3-yl] -piperidine- 1-carboxylic acid ethyl ester. After standard work-up 4.19 g (97% of yield) of the expected product were obtained. C. Preparation of 2- (2-{4- [1- (5-chloro- thiophen-2 -ylmethyl) - lH-indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid 5 This compound was prepared following the procedure described in example 13 (part D) , starting with 4.21 mmol (13 mmol) of 1- (5-chloro-thiophen-2-ylmethyl) -3-piperidin-4-yl-lH-indole and 3.6 g (17 mmol) of of 2- (2-chloro-ethoxy) -benzoic acid methyl ester. After the standard work-up, 2.47 g of the 0 corresponding acid was obtained. The crude mixture was purified by flash chromatography over silica gel affording 1.2 g (17% of yield) of the pure acid. Melting point 178-179°C NMR (300 MHz, DMSO) 5=1.86-2.05 (m, 4H) , 2.58-2.69 (m, 2H) , 2.87-2.98 (m, 3H) , 3.17-3.23 (m, 2H) , 4.41-4.45 (m, 2H) , 5.50 (s, 2H) , 5.40-5.80 (m, IH) , 6.95-7.05 (m, 4H) , 7.10-7.16 (m, IH) , 7.21-7.24 (m, 2H) , 7.36-7.41 ( , IH) , 7.47-7.55 (m, 2H) , 7.64-7.68 (d, IH) . Example 21 Preparation of 2- (2-{4- [1- (3- [1, 3] dioxolan-2-yl-propyl) -1H- indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid A solution of 2.75 g (7 mmol) of 2- (2- [4- (lH-indol-3 -yl) - piperidin-1-yl] -ethoxy} -benzoic acid methyl ester (prepared as in Example 1, part D) in 10 mL of anhydrous DMF was added to a suspension of 0.36 g (9.1 mmol) of a NaH (60% dispersion in mineral oil) in 5 mL of anhydrous DMF under an inert atmosphere. After stirring for 30 minutes at room temperature, a solution of 1.1 mL (8.4 mmol) of 2-(3-chloro- propyl) - [1, 3] dioxolane in 3 L of DMF was added. The crude mixture was stirred at room temperature for 16 hours and the solvent was removed under reduced pressure. The residue obtained was dissolved with 150 mL of ethanol and 6 mL of a 2N NaOH aqueous solution were added. After 12h at room temperature, the solvent was removed under reduced pressure. The crude mixture was dissolved with 50 mL of water and neutralised with a 2N HCl aqueous solution. The crude mixture was purified by flash chromatography over silica gel affording 0.83 g (29% of yield) of the expected product. Melting point 147-149°C NMR (300 MHz, DMSO) 5=1.50-1.56 (m, 2H) . 1 . 75 - 1 . 86 (m, 2H) , 1.89-1.97 (m, 4H) , 2.61-2.69 (m, 2H) , 2 . 79 - 2 . 99 (m, 3H) , 3.21-3.24 (d, 2H) , 3.70-3.75 (m, 2H) , 3 . 82 - 3 . 87 ( , 2H) , 4.13-4.17 (m, 2H) , 4.42-4.46 (m, 2H) , 4 . 76 - 4 . 80 ( , IH) , 5.00-5.40 (bs, IH) , 6.99-7.02 (m, 2H) , 7 . 10 - 7 . 24 (m, 3H) , 7.37-7.43 (m, 2H) , 7.52-7.54 (d, IH) , 7.64-7.66 (d, IH) . Example 22 Preparation of 2-{2- [4- (6-fluoro- 1-furan-2 -ylmethyl-IH-indol- 3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid A. Preparation of 6-fuoro-3-piperidin-4-yl-lH-indole This compound was prepared following the procedure described in example 1 (parts A and B) starting with 1 g (7.4 mmol) of 6-fluoroindol and 2.84 g (18.5 mmol) of 4-piperidone monohydrate hydrochloride . In this case, the hydrogenation step took place for 1 hour at 30 psi and the catalyst used was platinum (IV) oxide. 0.640 g (51% yield) of 6-fluoro-3- piperidin-4-yl-lH-indole .were obtained. ESI/MS m/e = 219 [(M+l) + , C13 H15 F N2] B. Preparation of 4- (6-fluoro-IH-indol-3-yl) -piperidine-1- carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part A) starting with 4.4 g (20 mmol) of 6- fluoro-3-piperidin-4-yl-lH-indole . After standard work-up, 5.2 g (90% of yield) of 4- (6-fluoro- lH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester were obtained. C. Preparation of 4- (6-fluoro-l-furan-2 -ylmethyl-lH-indol-3- yl) -piperidine-1-carboxylic acid ethyl ester This compound was obtained following procedure described in example 13 (part B) at room temperature for -5 hours, starting with 5 g (17.2 mmol) of 4- (6-fluoro-lH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester were and 3.2 g (20 mmol) of 2-bromomethyl-furan. After standard work-up, 6.4 g (99% of yield) of 4- (6-fluoro-1-furan-2 -ylmethyl -lH-indol-3- yl) -piperidine-1-carboxylic acid ethyl ester were obtained. D. Preparation of 6-fluoro-l-furan-2-ylmethyl-3-piperidin-4- yl-lH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 6.4 g (17.2 mmol) of 4- (6-fluoro- 1-furan-2 -ylmethyl-IH-indol-3 -yl) -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 4.4 g (86% of yield) of 6-fluoro-1-furan-2 -ylmethyl-3 -piperidin-4- yl-lH-indole were obtained. E. Preparation of 2- {2- [4- (6-fluoro-l-furan-2-ylmethyl-lH- indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid This compound was prepared following the procedure described in example 13 (part E) starting with 2 g (6.5 mmol) of 6- fluoro-l-furan-2-ylmethyl-3-piperidin-4-yl-lH-indole and 1.5 g (7.1 mmol) of 2 - (2-chloro-ethoxy) -benzoic acid methyl ester. After standard work-up and purification by flash chromatography over silica gel, 0.9 g (30% of yield) of the expected acid were obtained. Melting point 174-175°C NMR (300 MHz, DMSO) 5=1.83-1.95 (m, 4H) , 2.58-2.66 (m, 2H) , 2.79-2.94 (m, 3H) , 3.16-3.22 (d, 2H) , 4.00-4.40 (bs, IH) , 4.33-4.39 (m, 2H) , 5.35 (s, 2H) , 6.40 (s, IH) , 6.45-6.47 (m, IH) , 6.97-7.66 (m, 10H) . Example 23 Preparation of 2- (2-{4- [1- (2- [1, 3] dioxolan-2 -yl-ethyl) -1H- indol-3 -yl] -piperidin-1-yl} -ethoxy) -benzoic acid A. Preparation of 4- [1- (2- [1, 3] dioxolan-2 -yl-ethyl) -1H- indol-3-yl] -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 4 g (0.015 mol) of 4- (lH-indol-3 -yl) - piperidine-1-carboxylic acid ethyl ester and 2.07 mL (0.018 mol) of 2- (2-bromo-ethyl) - [1, 3] dioxolane . After standard work-up, 5.3 g of 4- [1- (2- [1 , 3] dioxolan-2 -yl-ethyl) -lH-indol- 3-yl] -piperidine-1-carboxylic acid ethyl ester were obtained. ESI/MS m/e = 373 [(M+l)\ C21 H28 N2 04] NMR (300 MHz, CDCl 3 ) 5=1.25-1.28 (t, 3H) , 1.64-1.70 (m, 4H) , 2.01-2.17 ( , 4H) , 2.88-3.00 (m, 3H) , 3.82-4.05 ( , 4H) , 4.18-4.27 (m, 4H) , 4.81-4.86 (t, IH) , 6.86 (s, IH) , 7.05-7.26 (m, 2H) , 7.34-7.38 (d, IH) , 7.59-7.63 (d, IH) . B. Preparation of 1- (2- [1, 3] dioxolan-2-yl-ethyl) -3 -piperidin- 4-yl-lH-indole This compound was obtained following the procedure described in example 13 (part C) starting with 5.3 g (0.015 mol) of 4- [1- (2- [1, 3] dioxolan-2-yl-ethyl) -lH-indol-3-yl] -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 4g (89% t of yield) of 1- (2- [1, 3] dioxolan-2 -yl-ethyl) -3-piperidin-4-yl- 1H-indole were obtained. ESI/MS m/e = 301 [(M+l) + , C18 H24 N2 02] NMR (300 MHz, CDC1 3 ) 5=1.61-1.76 (m, 2H) , 2.01-2.21 (m, 5H) , 2.74-3.02 (m, 3H) , 3.16-3.22 (m, 2H) , 3.82-4.04 ( , 4H) , 4.20-4.4.27 (t, 2H) , 4.81-4.86 (t, IH) , 6.87 (s, IH) , 7.07- 7.25 (m, 2H) , 7.32-7.36 (d, IH) , 7.61-7.65 (d, IH) . C. Preparation of 2- (2-{4- [1- (2- [1, 3] dioxolan-2-yl-ethyl) -1H- indol-3-yl] -piperidin-l-yl}-ethoxy) -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 3 g (0.01 mol) of 1- (2- [1, 3] dioxolan-2 -yl-ethyl) -3-piperidin-4-yl-lH-indole and 2.8 g (0.013 mol) of 2- (2-chloro-ethoxy) -benzoic acid methyl ester. The crude mixture was purified by flash chromatography over silica gel affording 1.86 g (40% of yield) of 2-(2-{4- [1- (2- [1, 3] dioxolan-2 -yl-ethyl) -lH-indol-3-yl] -piperidin-1- yl} -ethoxy) -benzoic acid. Melting point 118-120°C NMR (300 MHz, CDCl 3 ) 5=2.18-2.28 (m, 4H) , 2.47-2.56 ( , 2H) , 3.00-3.15 ( , 3H) , 2.52-3.56 (m, 2H) , 3.77-3.90 (m, 4H) , 4.00- 4.05 (m, 2H) , 4.20-4.22 (t, 2H) , 4.64-4.68 (m, 2H) , 4.85-4.89 (m, IH) , 7.01-7.12 (m, 4H) , 7.20-7.25 (t, IH) , 7.36-7.39 (d, IH) , 7.49-7.54 (t, IH) , 7.61-7.63 (d, IH) , 7.90-7.93 (d, IH) . Example 24 Preparation of 2- (2-{4- [1- (2- [1, 3] dioxolan-2 -yl-ethyl) -6- fluoro-lH-indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid A. Preparation of 4- (6-fluoro-IH-indol-3 -yl) -piperidine-1- carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part A) starting with 0.4 g (1.83 mmol) of 6- fluoro-3-piperidin-4-yl-lH-indole, 0.2 mL (2.13 mmol) of ethyl chloroformiate and 0.32 mL (2.13 mmol) of triethylamine. 0.32 g (60% yield) of 4- (6-fluoro-lH-indol-3 - yl) -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 4- [1- (2- [1, 3] dioxolan-2-yl-ethyl) -6-fluorα- IH-indol-3-yl] -piperidine- 1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.1 g (0.37 mmol) of 4- (6-fluoro-lH-indol-3 - yl) -piperidine-1-carboxylic acid ethyl ester and 0.081 g (0.45 mmol) of 2- (2 -bromo-ethyl) - [1, 3] dioxolane . 0.170 g (quantitative yield) of 4- [1- (2- [1, 3] dioxolan-2-yl-ethyl) -6- fluoro-lH-indol-3-yl] -piperidine-1-carboxylic acid ethyl ester were obtained. ESI/MS m/e = 391 [(M+l)\ C21 H27 F N2 04] C. Preparation of 1- (2- [1, 3] dioxolan-2 -yl-ethyl) -6-fluoro- 3 -piperidin-4-yl-lH-indole This compound was prepared following the procedure described in Example 13 (part C) starting with 170 g (0.448 mmol) of 4- [1- (2- [1, 3] dioxolan-2-yl-ethyl) -6-fluoro-lH-indol-3-yl] - piperidine-1-carboxylic acid ethyl ester. 0.04 g (28% yield) of 1- (2- [1, 3] dioxolan-2 -yl-ethyl) -6-fluoro-3-piperidin-4-yl- 1H-indole were obtained. ESI/MS m/e = 319 [(M+l)\ C18 H23 F N2 02] NMR (300 MHz, CDC1 3 ) 5=1.60-1.74 (m, 2H) , 1.99-2.18 (m, 5H) , 2.73-2.95 (m, 3H) , 3.16-3.22 (m, 2H) , 3.82-4.04 (m, 4H) , 4.12-4.20 (t, 2H) , 4.80-4.85 (t, IH) , 6.86 (s, IH) , 6.99-7.05 (dd, IH) , 7.15-7.25 (m, IH) , 7.48-7.55 (dd, IH) . D. Preparation of 2- (2-{4- [1- (2- [1, 3] dioxolan-2 -yl-ethyl) -6- fluoro-lH-indol-3-yl] -piperidin- 1-yl} -ethoxy) -benzoic acid This compound was prepared following the procedure described in Example 13 (part D) starting with 0.04 g (0.11 mmol) of 1- (2- [1,3] dioxolan-2 -yl-ethyl) -6-fluoro-3 -pipe idin-4-yl-lH- indole and 0.03 g (0.15 mmol) of of 2- (2-chloro-ethoxy) - benzoic acid methyl ester. After purification over a Varian C18 column, 0.012 g (22% yield) were obtained. Melting point 150-151°C NMR (300 MHz, CDCl 3 ) 5=1.94-2.04 (m, 6H) , 2.61-2.64 (m, 2H) , 2.89-2.98 (m, 3H) , 3.20-3.23 (d, 2H) , 3.78-3.95 (m, 4H) , 4.15-4.19 (t, 2H) , 4.41-4.44 (m, 2H) , 4.77-4.80 (t,lH), 5.47 (bs, IH) , 6.82-6.88 (t, IH) , 6.99-7.04 (t, IH) , 7.16-7.27 (m, 3H) , 7.36-7.41 (t, IH) , 7.52-7.55 (d, IH) , 7.64-7.69 (t, IH) . Example 25 Preparation of 3- [4- (l-thiophen-2-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid A. Preparation of 4- (1-thiophen-2-ylmethyl-IH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 4 g (15 mmol) of 4- (IH-indol-3-yl) -piperidine- 1-carboxylic acid ethyl ester and 30 mL of a freshly prepared 2-bromomethyl-thiophene 0.61M solution in anhydrous ethyl ether. After standard work-up, 5.6 g (100% of yield) of the expected product was obtained. B. Preparation of 3 -piperidi -4 -yl-1-thiophe -2 -ylmethyl-1H- indole This compound was prepared following the procedure described in example 13 (part C) starting with 5.6 g (15 mmol) of 4-(l- thiophen-2 -ylmethyl-IH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester. After standard work-up 4.35 g (98% of yield) of the expected product were obtained. C. Preparation of 3- [4- (l-thiophen-2-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) , starting with 4.35 mmol (15 mmol) of 3-piperidin-4-yl-l-thiophen-2-ylmethyl-lH-indole and 4.58 g (20 mmol) of 3 -bromomethyl-benzoic acid methyl ester. After the standard work-up, 3.3 g of the corresponding acid was obtained. The crude mixture was purified by flash chromatography over silica gel affording 0.64 g (10% of yield) of the pure acid. Melting point 228-229°C NMR (300 MHz, DMSO) 5=1.55-1.79 (m, 2H) , 1.87-1.97 (m, 2H) , 2.10-2.22 (t, 2H) , 2.73-2.81 (t, IH) , 2.90-2.94 (m, 2H) , 3.59 (s, 2H) , 5.52 (s, 2H) , 6.92-7.01 (m, 2H) , 7.07-7.13 (m, 2H) , 7.24 (s, IH) , 7.36-7.57 (m, 5H) , 7.83-7.86 (d, IH) , 7.92-7.94 (m, IH) . Example 26 Preparation of 3- [4- (l-pyridin-3-ylmethyl-lH-indol-3-yl) - piperidin- 1-ylmethyl] -benzoic acid A. Preparation of 4- (l-pyridin-3-ylmethyl-lH-indol-3-yl) - piperidine- 1-carboxylic acid ethyl ester This compound was prepared following the , procedure described in example 13 (part B) at room temperature for 16 hours, starting with 11 -g (40 mmol) of 4- (lH-indol-3 -yl) -piperidine- 1-carboxylic acid ethyl ester and 7.2 g (44 mmol) of 3- chloromethyl-pyridine hydrochloride. After standard work-up, 13 g of a crude oil was obtained. This crude was precipitated with ethyl ether affording 10.8 g (90% of yield) of a white solid. B. Preparation of 3 -piperidin-4 -yl- 1-pyridin-3 -ylmethyl-1H- indole This compound was prepared following the procedure described in example 13 (part C) starting with 10.8 g (30 mmol) of 4- ( 1-pyridin-3 -ylmethyl -IH-indol -3-yl) -piperidine-1-carboxylic acid ethyl ester. After standard work-up 9.3 g of a crude oil were obtained. The corresponding fumarate derivative was prepared in ethanol affording 9.8 g of a white solid. After treatment with aqueous NaOH and extraction with ethyl acetate, 5.3 g (62% of yield) of pure 3 -piperidin-4-yl-l- pyridin-3 -ylmethyl-IH-indole were obtained. C. 3- [4- (l-pyridin-3-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid A solution containing 1.2 g (52 mmol) of 3-bromomethyl- benzoic acid methyl ester in 10 mL of anhydrous dichloromethane was added dropwise over a solution of 1.5 g (5 mmol) 3-piperidin-4-yl-l-pyridin-3-ylmethyl-lH-indole and 0.8 mL (55 mmol) of triethylamine in 35 of anhydrous dichloromethane. After stirring at room temperature for 5 hours, the crude mixture was washed with water, saturated solution of sodium hydrogencarbonate and water. The organic phase was dried and the solvent was removed under reduced pressure. The crude mixture was purified by flash chromatography over silica gel affording 0.95 g (43% of yield) of 3- [4- (l-pyridin-3-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid methyl ester. This ester was dissolved in 15 mL of methanol and hydrolised with NaOH IN at room temperature for 12 hours . The crude mixture was neutralised with HCl IN and then the solvent was removed under reduced pressure. The solid residue was washed with water and dichloromethane and the corresponding acid (0.6 g, 77% of yield) was isolated by filtration. Melting point 190-192°C NMR (300 MHz, DMSO) 5=1.92-2.21 (m, 4H) , 2.98-3.20 (m, 2H) , 3.32-3.43 (m, 3H) , 4.38 (s, 2H) , 5.42 (s, 2H) , 6.98-7.03 (t, IH) , 7.08-7.14 (t, IH) , 7.29-7.37 (m, 2H) , 7.46-7.49 (d, IH) , 7.56-7.64 (m, 2H) , 7.68-7.72 (d, IH) , 7.94-7.97 (d, IH) , 8.00-8.03 (d, IH) , 8.20 (s, IH) , 8.43-8.47 (d, IH) , 8.50 (s, IH) . Example 27 Preparation of 3-{4- [1- (5-chloro- thiophen-2 -ylmethyl) -1H- indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 19 (part C) starting with 1.48 mmol (4.48 mmol) of 1- (5-chloro-thiophen-2 -ylmethyl) -3 -piperidin-4-yl-lH-indole and 1.0 g (8.8 mmol) of 3 -bromomethyl -benzoic acid methyl ester. The crude mixture was purified by flash chromatography over silica gel affording 0.29 g (14% of yield) of the pure acid. Melting point 232-234°C NMR (300 MHz, DMSO) 5=1.91-2.09 (m, 4H) , 2.88-3.20 ( , 2H) , 3.22-3.36 (m, 3H) , 4.34 (s, 2H) , 5.48 (s, 2H) , 6.93-7.03 (m, 3H) , 7.09-7.12 (m, IH) , 7.25 (s, IH) , 7.50-7.66 (m, 3H) , 7..84-7.86 (m, IH) , 7.99-8.01 (d, IH) , 8.15 (s, IH) . Example 28 Preparation of 3-{4- [1- (2- [1, 3] dioxolan-2 -yl-ethyl) -lH-indol- 3-yl] -piperidin-1-ylmethyl} -benzoic acid A. Preparation of 3- [4- (lH-indol-3-yl) -piperidin-1-ylmethyl] - benzoic acid methyl ester This compound was prepared following the procedure described in example 1 (part D) starting with 0.2 g (1 mmol) of 3- piperidin-4-yl-lH-indole and 0.29 g (1.3 mmol) of 3- bromomethyl -benzoic acid methyl ester. After ionic exchange purfication, 0.276 g (79% of yield) of 3- [4- (lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid methyl ester were obtained. B. Preparation of 3-{4- [1- (2- [1, 3] dioxolan-2 -yl-ethyl) -1H- indol-3-yl] -piperidin-1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.046 g (0.13 mmol) of 3- [4- (lH-indol-3-yl) -piperidin- 1-ylmethyl] -benzoic acid methyl ester and 0.019 L (0.16 mmol) of 2- (2 -bromo-ethyl) - [1, 3] dioxolane. After the described purification, 0.023 g (40% of yield) of the expected acid was obtained. NMR (300 MHz, DMSO) 5=1.64-1.75 (m, 2H) , 1.90-1.95 (m, 2H) , 1.99-2.06 (m, 2H) , 2.12-2.19 (m, 2H) , 2.72-2.80 ( , IH) , 2.90-2.94 ( , 2H) , 3.59 (s, 2H) , 3.72-3.80 ( , 2H) , 3.87-3.93 (m, 2H) , 4.11-4.21 (t, 2H) , 4.75-4.78 (t, 2H) , 6.99-7.00 (t, IH) , 7.08-7.14 (m, 2H) , 7.35-7.46 (m, 2H) , 7.54-7.56 (m, 2H) , 7.83-7.85 (m, 2H) , 7.93 (s, 2H) . Examples 29-33 These compounds were prepared following the procedure described in example 28. The ESI/MS data, yields and purity are summarised in table 5. Example 34 Preparation of 2 -methoxy-5- [4- (l-pyridin-3 -ylmethyl-IH-indol- 3-yl) -piperidin- 1-ylmethyl] -benzoic acid A. Preparation of 5- [4- (lH-indol-3-yl) -piperidin-1-ylmethyl] - 2-methoxy-benzoic acid ethyl ester This compound was prepared following the procedure described in example 1 (part D) starting with 0.2 g (1 mmol) of 3- piperidin-4-yl-lH-indole and 0.34 g (1.3 mmol) 5-bromomethyl- 2-methoxy-benzoic acid ethyl ester. After ionic exchange purfication, 0.273 g (70% of yield) of 5- [4- (lH-indol-3 -yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid ethyl ester were obtained. B. Preparation of 2 -methoxy-5- [4- (l-pyridin-3 -ylmethyl -1H- indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.054 g (0.13 mmol) of 5- [4- (IH-indol -3-yl) -piperidin-1-ylmethyl] -2-methoxy-benzoic acid methyl ester and 0.029 mg (0.16 mmol) of 3 -chloromethyl - pyridine hydrochloride. After the described purification, 0.007 g (11% of yield) of the expected acid was obtained. NMR (300 MHz, DMSO) 5=1.61-1.72 (m, 2H) , 1.87-1.95 (m, 2H) , 2.04-2.11 (m, 2H) , 2.70-2.78 (m, IH) , 2.88-2.92 (d, 2H) , 3-71 (s, 3H) , 5.39 (s, 2H) , 6.86-6.89 (d, IH) , 6.96-7.33 (m, 6H) , 7.43-7.46 (d, IH) , 7.55-7.58 (d, IH) , 8.43-8.45 (d, IH) , 8.51 (s, IH) . Examples 35-39 These compounds were prepared following the procedure described in example 34. The ESI/MS data, yields and purity are summarised in table 6. Table 6 . Examples 35 - 3 i Example 39 Preparation of 4 -bromo-3- [4- (1- [1, 3] dioxolan- 2 -ylmethyl-1H- indol-3-yl) -piperidin- 1-ylmethyl] -benzoic acid A. Preparation of 4-bromo-3- [4- (lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid methyl ester This compound was prepared following the procedure described in example 1 (part D) starting with 0.2 g (1 mmol) of 3- piperidin-4-yl-lH-indole and 0.39 g (1.3 mmol) 4-bromo-3- bromomethyl -benzoic acid methyl ester. After ionic exchange purfication, 0.196 g (46% of yield) of 4-bromo-3- [4- (1H- indol-3 -yl) -piperidin-1-ylmethyl] -benzoic acid methyl ester were obtained. B. Preparation of 4-bromo-3- [4- (1- [1, 3] dioxoIa -2 -ylmethyl- IH-indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.055 g (0.13 mmol) 4- bromo-3- [4- (lH-indol-3 -yl). -piperidin-1-ylmethyl] -benzoic acid methyl ester and 0.034 mg (0.16 mmol) 2-bromomethyl- [1, 3] dioxolane . After the described purification, 0.021 g (32% of yield) of the expected acid was obtained. NMR (300 MHz, DMSO) 5=1.62-1.74 (m, 2H) , 1.90-1.95 (m, 2H) , 2.19-2.23 (m, 2H) , 2.74-2.82 (m, IH) , 2.93-3.00 (m, 2H) , 3.58 (s, 2H) , 4.23-4.25 (m, 2H) , 5.08-5.12 (t, IH) , 6.95-7.00 (t, IH) , 7.07-7.15 (m, 2H) , 7.41-7.69 (m, 4H) , 7.98-8.00 (m, IH) . Examples 40-45 These compounds were prepared following the procedure described in example 39. The ESI/MS data, yields and purity are summarised in table 7. Example 46 Preparation of 2 -fluoro-5- [4- (1-pyridin- 3 -ylmethyl-lH-indol- 3-yl) -piperidin- 1-ylmethyl] -benzoic acid A. Preparation of 2-fluoro-5- [4- (lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid ethyl ester This compound was prepared following the procedure described in example 1 (part D) starting with 0.2- g (1 mmύl) of 3- piperidin-4-yl-lH-indole and 0.33 g (1.3 mmol 5-bromomethyl- 2 -fluoro-benzoic acid ethyl ester. After ionic exchange purfication, 0.30 g (79% of yield) of 2-fluoro-5- [4- (1H- indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid ethyl ester were obtained. B. Preparation of 2-fluoro-5- [4- (l-pyridin-3 -ylmethyl-lH- indol-3-yl) -piperidin- 1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.063 g (0.17 mmol) of 2- fluoro-5- [4- (lH-indol-3-yl) -piperidin- 1-ylmethyl] -benzoic acid ethyl ester and 0.035 mg (0.21 mmol) of 3 -chloromethyl - pyridine hydrochloride. After the described purification, 0.053 g (71% of yield) of the expected acid was obtained. NMR (300 MHz, DMSO) 5=1.67-1.77 (m, 2H) , 1.90-1.95 (m, 2H) , 2.09-2.17 (t, 2H) , 2.73-2.81 (m, IH) , 2.88-2.93 (d, 2H) , 3.49 (s, 2H) , 5.38 (s, 2H) , 6.95-7.10 (m, 3H) , 7.24-7.35 (m, 2H) , 7.43-7.46 (d, IH) , 7.54-7.61 (m, 4H) , 8.42-8.45 (dd, IH) , 8.50-8.52 (m, IH) . Examples 47-52 These compounds were prepared following the procedure described in example 46. The ESI/MS data, yields and purity are summarised in table 8. Example 53 Preparation of 2- (2-{4- [1- (tetrahydro-furan-3 -ylmethyl) -1H- indol-3-yl] -piperidin- 1-yl} -ethoxy) -benzoic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.1 g (0.26 mmol) of 2- {2- [4- (lH-indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid methyl ester and 0.067 g (0.37 mmol) of freshly prepared tetrahydro-furan-3 -ylmethyl methansulfonate. After standard purification, 0.045 g (39% of yield) of the expected acid were obtained. NMR (300 MHz, DMSO) 5=1.82-1-98 ( , 4H) 2.44-2.56 (m, 5H) , 2.67-2.78 (m, IH) , 2.81-2.93 (m, 2H) , 3.15-3.20 (m, 2H) , 3.57-3.66 (m, 2H) , 3.78-3.86 (m, 2H) , 4.08-4.11 (m, 2H) , 4.29-4.33 (m, 2H) , 6.89-7.02 (m, 2H) , 7.09-7.18 (m, 3H) , 7.27-7.49 (m, 3H) , 7.62-7.64 (d, IH) . Examples 54-57 These compounds were prepared following the procedure described in example 53 starting with the suitable methansulfonate or halide. The ESI/MS data, yields and purity are summarised in table 9. Table 9 . Examples 54 - 57 Example 58 Preparation of 3-{4- [1- ( tetrahydro-furan-3 -ylmethyl) - IH- indol -3-yl] -piperidin- 1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.1 g (0.28 mmol) of 3- [4- (lH-indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid methyl ester (example 28, part A) and 0.72 g (0.4 mmol) of (tetrahydro-furan-3-yl) -methansulfonate. After standard purification, 0.04 g (34% of yield) of the expected acid were obtained. NMR (300 MHz, DMSO. 5=1.53-1.94 (m, 5H) 2.07-2.14 (t, 2H) , 2.61-2.79 (m, 2H) , 2.89-2.94 (m, 3H) , 3.40-3.71 (m, 4H) , 3.77-3.85 (m, 2H) , 4.05-4.09 (d, 2H) , 6.95-7.00 (t, IH) , 7.07-7.13 (m, IH) , 7.25-7.34 ( , 3H) , 7.42-7.45 (d, IH) , 7.53-7.56 (d, IH) , 7.74-7-77 (d, IH) , 7.83-7.87 (m, IH) . Examples 59-51 These compounds were prepared following the procedure described in example 58 starting with the suitable methansulfonate or halide. The ESI/MS data, yields and purity are summarised in table 10. Table 10. Examples 59-61 Example 62 Preparation of 2- [4- (l-pyridin-3 -ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -nicotinic acid A. Preparation of 2- [4- (lH-indol-3-yl) -piperidin-1-ylmethyl] - nicotinic acid ethyl ester This compound was prepared following the procedure described in example 1 (part D) starting with 0.5 g (2.5 mmol) of 3-piperidin-4-yl-lH-indole and 0.65 g (3.25 mmol) of 2- bromomethyl-nicotinic acid ethyl ester. After the standard purification, 0.84 g (92% of yield) of 2- [4- (lH-indol-3-yl) - piperidin- 1-ylmethyl] -nicotinic acid ethyl ester were obtained. B. Preparation of 2- [4- (l-pyridin-3-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -nicotinic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.76 g (0.21 mmol) of 2- [4- (lH-indol-3-yl) -piperidin-1-ylmethyl] -nicotinic acid ethyl ester and 0.04 g (0.25 mmol) of 3 -chloromethyl -pyridine hydrochloride. After standard purification, 0.040 g (45% of yield) of the expected acid were obtained. NMR (300 MHz, DMSO) 5=1.65-1.79 (m, 2H) , 1.99-2.10 (m, 2H) , 2.55-2.76 (m, 2H) , 2.89-2.96 (t, IH) , 3.08-3.12 (d, 2H) , 4.24 (s, 2H) , 5.40 (s, 2H) , 6.98-7.12 (dt, 2H) , 7.29-7.39 (m, 3H) , 7.44-7.47 (d, IH) , 7.55-7.61 (m, 2H) , 8.06-8.08 (d, IH) , 8.43-8.45 (m, IH) , 8.49-8.51 (m, IH) . Examples 63-64 These compounds were prepared following the procedure described in example 62 starting with the suitable methansulfonate or halide. The ESI/MS data, yields and purity are summarised in table 11. Table 11. Examples 63-64 Example 65 Preparation of 3 -{4- [1- (5 -chloro-thiophen-2 -ylmethyl) -6- fluoro-lH-indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid A. Preparation of 3- [4- (6-fluoro-IH-indol -3 -yl) -piperidin-1- ylmethyl] -benzoic acid methyl ester This compound was prepared following the procedure described in example 1 (part D) starting with 0.5 g (2.3 mmol) of 6- fluoro-3-piperidin-4-yl-lH-indole and 0.7 g (3 mmol) of 3- bromomethyl-benzoic acid. After the standard purification, 0.842 g (93% of yield) of 3 - [4- (6-fluoro-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid methyl ester -were obtained. B. Preparation of 3 -{4- [1- (5-chloro-thiophen-2 -ylmethyl) -6- fluoro-lH-indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.07 g (0.19 mmol) of 3- [4- (6-fluoro-lH-indol-3-yl) -piperidin- 1-ylmethyl] -benzoic acid methyl ester and 0.05 g (0.29 mmol) of 2-chloro-5- chloromethyl-thiophene. After standard purification, 0.01 g (10% of the yield) of the expected acid were obtained. NMR (300 MHz, DMSO) 5=2.14-2.29 (m, 4H) , 2.76-2.85 (m, 2H) , 2.94-3.01 (m, IH) , 3.47-3.54 (m, 2H) , 4.17 (s, 2H) , 5.25 (s, 2H) , 6.71-6.79 ( , 2H) , 6.83-6.90 (dt, IH) , 6.97-7.03 (m, 2H) , 7.48-7.56 (m, 2H) , 7.75-7.78 (d, IH) , 8.09-8.12 (m, 2H) , 8.15-8.19 (m, IH) . Examples 66-67 Compounds 66 and 67 were prepared following the procedure described in example 65 starting with the suitable methansulfonate or halide. The ESI/MS data, yields and purity are summarised in table 11. Table 11. Examples 66-67 Example 68 Preparation of 2 -methoxy-5 -{4- [1- (2-thiophen-2-yl-ethyl) -1H- indol-3-yl] -piperidin-1-ylmethyl} -benzoic acid A. Preparation of 5- [4- (lH-indol-3 -yl) -piperidin-1-ylmethyl] - 2-methoxy-benzoic acid ethyl ester This compound was prepared following the procedure described in example 1 (part D) starting with 0.5 g (2.5 mmol) of 6- fluoro-3-piperidin-4-yl-lH-indole and 0.88 g (3.2 mmol) of 5- bromomethyl -2-methoxy-benzoic acid ethyl ester. After standard purification, 0.83 g (91% of yield) of 5- [4- (1H- indol-3-yl) -piperidin-1-ylmethyl] -2-methoxy-benzoic acid ethyl ester were obtained. B. Preparation of 2 -methoxy-5 -{4- [1- (2 -thiophen-2 -yl-ethyl) - lH-indol-3 -yl] -piperidin-1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 1 (part E) starting with 0.07 g (0.18 mmol) of 5- [4- (lH-indol-3-yl) -piperidin-1-ylmethyl] -2-methoxy-benzoic acid ethyl ester and 0.05 g (0.25 mmol) of 2 -thiophen-2 -yl- ethyl methansulfonate. After the standard purification, 0.009 g (10% of yield) of the expected acid was obtained. Examples 69 and 70 A. Preparation of 5- [4- (6-fluoro-IH-indol-3 -yl) -piperidin-1- ylmethyl] -2-methoxy-benzoic acid ethyl ester This compound was prepared following the procedure described in example 1 (part D) starting with 0.5 g (2.2 mmol) of 6- fluoro-3-piperidin-4-yl-lH-indole and 0.8 g (2.9 mmol) of 5- bromomethyl -2-methoxy-benzoic acid ethyl ester. After standard purification, 0.91 g (100% of yield) of 5- [4- (6- fluoro-lH-indol-3-yl) -piperidin-1-ylmethyl] -2-methoxy-benzoic acid ethyl ester were obtained. B. Preparation of 5-{4- [6-fluoro-1- (2-thiophen-2-yl-ethyl) - lH-indol-3-yl] -piperidin-1-ylmethyl} -2-methoxy-benzoic acid and 5-{4- [6-fluoro-l- (2 -morpholin-4-yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -2-me hoxy-benzoic acid These compounds were prepared following the procedure described in example 1 (part E) starting with 0.07 g (0.17 mmol) of 5- [4- (6-fluoro-lH-indol-3 -yl) -piperidin-1-ylmethyl] - 2-methoxy-benzoic acid ethyl ester. Example 71 Preparation of 5-{4- [1- (2- [1, 4] dioxan-2 -yl-ethyl) -lH-indol-3- yl] -piperidin- 1-ylmethyl} -2-methoxy-benzoic acid A. Preparation of 4- [1- (2- [1, 4] dioxan-2 -yl-ethyl) -lH-indol-3^ yl] -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 0.47 g (1.2 mmol) of 4- (lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester and 0.62 g (2.9 mmol) of 2- [1, 4] dioxan-2-yl-ethyl methansulfonate. The reaction mixture was stirred at 40 °C for 24 hours. After standard work-up and purification, 0.47 g (51% of yield) of 4- [1- (2 - [1, 4] dioxan-2 -yl-ethyl) -lH-indol-3- yl] -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 1- (2- [1, 4] dioxan-2 -yl-ethyl) -3-piperidin-4- yl-lH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 0.47 g (1.2 mmol) of 4- [1- (2- [1,4] dioxan-2-yl-ethyl) -lH-indol-3-yl] -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 0.2 g (53% of yield) of 1- (2- [1 , 4] dioxan-2 -yl-ethyl) -3-piperidin-4- yl-lH-indole were obtained. C. Preparation of 5-{4- [1- (2- [1, 4] dioxan-2 -yl-ethyl) -1H- indol-3-yl] -piperidin-l-ylmethyl}-2-methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.06 g (0.19 mmol) of 1- (2- [1,4] dioxan-2 -yl-ethyl) -3 -piperidin-4 -yl-lH-indole and 0.071 g (0.26 mmol) of 5-bromomethyl-2-methoxy-benzoic acid ethyl ester. After standard purification, 0.019 g (65% of yield) were obtained. NMR (300 MHz, CDC1 3 ) 5=1.73-1.80 ( , 2H) , 2.15-2.30 (m, 4H) , 2.55-2.80 (m, 2H) , 2.99-3.10 (m, IH) , 3.20-3.45 (m, 3H) , 3.52-3.67 (m, 3H) , 3.52-3.67 (m, 5H) , 3.78-3.82 (m, IH) , 3.98 (s, 3H) , 4.03-4.10 (m, 2H) , 4.18-4.23 (t, 2H) , 6.91 (s, IH) , 6.99-7.10 (m, 2H) , 7.17-7.22 (t, IH) , 7.30-7.35 (m, IH) , 7.56-7.58 (m, 3H) , 8.03-8.08 (m, IH) . Example 72 Preparation of 3-{4- [1- (2- [1, 4] dioxan-2 -yl-ethyl) -lH-indol-3- yl] -piperidin-1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 71 (part C) starting with 0.06 g (0.19 mmol) of 1- (2- [1, 4] dioxan-2 -yl-ethyl) -3 -piperidin-4-yl-lH- indole and 0.060 g (0.26 mmol) of 3 -bromomethyl -benzoic acid methyl ester. After standard purification, 0.037 g (75% of yield) were obtained. NMR (300 MHz, CDCl 3 ) 5=1.65-1.80 (m, 2H) , 2.10-2.24 (m, 2H) , 2.35-2.52 (m, 2H) , 2.81-3.09 (m, 3H) , 3.18-3.33 (m, 3H) , 3.51-3.66 (m, 5H) , 3.77-3.80 (m, IH) , 4.15-4.27 (m, 4H) , 6.93 (s, IH) , 7.02-7.07 (t, IH) , 7.15-7.20 (t, IH) , 7.25-7.33 (m, IH) , 7.40-7.56 (m, 2H) , 7.62-7.85 (m, IH) , 8.08-8.10 (d, IH) , 8.34 (s, IH) . Example 73 Preparation of 2-methoxy-5- [4- (1-thiophen-2 -ylmethyl-1H- indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 25 (part C) starting with 1.90 g (0.065 mol) of 3- piperidin-4-yl-l-thiophen-2-ylmethyl-lH-indole and 1.92 (0.071 mol) of 5-bromomethyl -2-methoxy-benzoic acid ethyl ester. After standard purification and recrystallisation with ethanol, 1.2 g (40% of yield) of the expected acid. Melting point 242-243°C NMR (300 MHz, DMSO) 5=1.6-1.73 (m, 2H) , 1.91-1.95 (d, 2H) , 2.09-2.17 (t, 2H) , 2.32-2.82 (m, IH) , 2.88-2.92 (d, 2H) , 3.49 (s, 2H) , 3.80 (s, 3H) , 5.52 (s, 2H) , 6.92-6.96 (m, IH) , 6.93- 7.00 (m, IH) , 7.06-7.12 (m, 3H) , 7.23 (s, IH) , 7.36-7.38 (dd, IH) , 7.42-7.46 (dd, IH) , 7.46-7.48 (m, IH) , 7.49-7.51 (m, IH) , 7.53-7.55 (m, IH) , 7.56-7.59 (m, 2H) . Example 74 Preparation of 4-bromo-3- [4- (l-pyridin-4-ylmethyl -IH-indol-3- yl) -piperidin-1-ylmethyl] -benzoic acid A. Preparation of 4- (1-pyridin-4-ylmethyl-lH-indol-3 -yl) - piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 11 g (40 mmol) of 4- (lH-indol-3-yl) -piperidine- 1-carboxylic acid ethyl ester and 8 g (48 mmol) of 4- chloromethyl-pyridine hydrochloride, stirring at room temperature for 18 hours. After standard work-up, 11.8 g (81% of the yield) of 4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 3 -piperidin-4-yl-l-pyridin-4-ylmethyl-lH- indole This compound was prepared following the procedure described •in example 13 (part C) starting with 11.8 (0.032 mol) of 4- (1-pyridin-4 -ylmethyl-IH-indol-3-yl) -piperidine- 1-carboxylic acid ethyl ester. After purification through the fumarate ■ derivative as described in example 26 (part B). , 6 g (64% of yield) of' 3-piperidin-4-yl-l-pyridin-4-ylmethyl-lH-indole were obtained. C. Preparation of 4-bromo-3- [4- (l-pyridin-4 -ylmethyl- 1H- indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 1.5 g (50 mmol) of 3- piperidin-4-yl-l-pyridin-4-ylmethyl-lH-indole and 1.7 g (55 mmol) of- 4-bromo-3 -bromomethyl-benzoic acid methyl ester. After standard- work-up and recrystallisation with ethyl ether, 1.7 g (68% of yield) of the expected acid were obtained. Melting point 167-168°C NMR (300 MHz, DMSO) 5=1.66-1.77 (m, 2H) , 1.91-2.02 (m, 2H) , 2.25-2.33 (t, 2H) , 2.80-2.97 (m, 3H) , 3.65 (s, 2H) , 5.42 (s, 2H) , 6.98-7.10 (m, 4H) , 7.31-7.33 (m, 2H) , 7.59-7.62 (d, ' IH) , 7.68-7.81 (m, ' 2H), 8.09 (s, IH) , 8.45-8.48 (m, 2H) . Example 75 Preparation of 2 -methoxy-5- {4 - [1- (2 -thiophen-3 -yl-ethyl) -1H- indol-3-yl] -piperidin-1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 1 g (3.2 mmol) of 3- piperidin-4-yl-l- (2-thiophen-3-yl-ethyl) -lH-indole and 1.15 g (4.2 mmol) of 5 -bromomethyl-2-methoxy-benzoic acid ethyl ester. After standard work-up and purification, 1.16 g (76% of yield) of the expected acid were obtained. Melting point 219-220°C NMR (300 MHz, DMSO) 5=1.58-1-70 (m, 2H) , 1.89-1.93 (d, 2H) , 2.11-2.19 (t, 2H) , 2.70-2.78 (m, 2H) , 2.89-2.93 (d, IH) , 3.02-3.07 (m, 2H) , 3.50 (s, 2H) , 3.80 (s, 3H) , 4.30-4.35 (m, 2H) , 6.95-7.12 (m, 5H) , 7.18 (s, IH) , 7.43-7.46 (m, 3H) , 7.53-7.55 (d, IH) , 7.59 (s, IH) . Example 76 Preparation of 3-{4- [1- (2-morpholin-4-yl-ethyl) -lH-indol-3- yl] -piperidin- 1-ylmethyl} -benzoic acid A. Preparation of 4- [1- (2-morpholin-4-yl-ethyl) -lH-indol-3 - yl] -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) , starting with 11 g (40 mmol) of 4- (lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester and 9 g (48 mmol) of 4- (2-chloro-ethyl) -morpholine hydrochloride. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up and purification, 13.5 g (88% of yield) of 4- [1- (2-morpholin-4-yl-ethyl) -IH-indol -3-yl] - piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 1- (2-morpholin-4-yl-ethyl) -3-piperidin-4- yl-lH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 13.5 g (35 mmol) of 4- [1- (2-morpholin-4-yl-ethyl) -lH-indol-3-yl] -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 9.5 g (87% of yield) of 1- (2-morpholin-4-yl-ethyl) -3-piperidin-4- yl-lH-indole were obtained. C. Preparation of 3-{4- [1- (2 -morpholin-4 -yl-ethyl) -lH-indol- 3-yl] -piperidin- 1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.4 g (7.5 mmol) of 1- (2-morpholin-4-yl-ethyl) -3-piperidin-4-yl-lH-indole and 1.8 g (7.8 mmol) of 3 -bromomethyl -benzoic acid methyl ester. After standard work-up and purification, 0.75 g (22% of yield) of the expected acid were obtained. Melting point 186-191°C NMR (300 MHz, DMSO) 5=1.91-2.10 (m, 4H) , 2.42-2.51 (m, 4H) , 2.66-2.82 (m, 4H) , 3.16-3.26 (m, 3H) , 3.54-3.58 (m, 4H) , 4.15-4.26 (m, 4H) , 6.96-7.00 (t, IH) , 7.09-7.14 (t, IH) , 7.18 (s, IH) , 7.42-7.45 (m, 2H) , 7.54-7.64 (m, 2H) , 7.84-7.86 (m, IH) , 7.95-7.98 (d, IH) , 8.11 (s, IH) . Example 77 Preparation of 2- [2- (4-{l- [2- (benzo [1, 3] dioxol-5-yloxy) - ethyl] -lH-indol-3-yl}-piperidin-l-yl) -ethoxy] -benzoic acid A. Preparation of 4-{l- [2- (benzo [1, 3] dioxol-5-yloxy) -ethyl] - lH-indol-3 -yl}-piperidine-l-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 11 g (40 mmol) of 4- (IH- indol-3-yl) -piperidine-1-carboxylic acid ethyl ester and 9.6 g (48 mmol) of 5- (2-chloro-ethoxy) -benzo [1, 3] dioxole . The mixture was stirred at room temperature for 18 hours. After standard work-up and purification, 10.5 g (60% of yield) of 4-{l- [2- (benzo[l,3]dioxol-5-yloxy) -ethyl] -lH-indol-3-yl} - piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 1- [2- (benzo [1, 3] dioxol-5-yloxy) -ethyl] -3- piperidin-4-yl-lH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 12.5 g (0.028 mmol) of 4-{l- [2- (benzo[l,3]dioxol-5-yloxy) -ethyl] -IH-indol-3 -yl} - piperidine-1-carboxylic acid ethyl ester. After standard work-up, 9 g (87% of yield) of 1- [2- (benzo [1, 3] dioxol-5- yloxy) -ethyl] -3-piperidin-4-yl-lH-indole were obtained. C. Preparation of 2- [2- (4-{l- [2- (benzo [1, 3] dioxol-5-yloxy) - ethyl] -lH-indol-3-yl}-piperidin-l-yl) -ethoxy] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.3 g (6.2 mmol) of 1- [2- (benzo [1,3] dioxol-5-yloxy) -ethyl] -3-piperidin-4-yl-lH- indole and 1.5 g (7.1 mmol) of 2- (2-chloroethoxy) -benzoic acid methyl ester. After standard work-up and recrystallisation with methanol, 1.6 g (49% of yield) of the expected acid were obtained. Melting point 123-125°C NMR (300 MHz, DMSO) 5=1.85-2.06 (m, 4H) , 2.61-2.69 (m, 2H) , 2.89-2.98 (m, 3H) , 3.16-3.24 (m, 2H) , 4.17-4.21 (m, 2H) , ' 4.42-4.49 (m, 4H) , 5.93 (s, 2H) , 6.30-6.33 (dd, IH) , 6.56- 6.57 (m, IH) , 6.76-6.78 (d, IH) , 6.97-7.04 (m, 2H) , 7.11-7.16 (t, IH) , 7.20-7.24 (m, 2H) , 7.36-7.41 (m, IH) , 7.48-7.55 (m, 2H) , 7.64-7.66 (d, IH) . Example 78 Preparation of 5-{4- [6-fluoro-1- (2-thiophen-3-yl-ethyl) -1H- indol-3-yl] -piperidin-l-ylmethyl}-2-methoxy-benzoic acid A. Preparation of 4- [6-fluoro-1- (2- hiophen-3 -yl-ethyl) -1H- indol-3-yl] -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 4 g (13.8 mmol) of 4- (6- fluoro-lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester (example 24, part A) and 3.3 g (16 mmol) of 2-thiophen- 3 -yl-ethyl methansulfonate. The reaction mixture was stirred at 60 °C for 3 hours. After standard work-up, 5.6 g (100% of yield) of 4- [6-fluoro-1- (2 -thiophen-3 -yl-ethyl) -lH-indol-3- yl] -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 6-fluoro-3-piperidin-4-yl-l- (2-thiophen-3 - yl-ethyl) -IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 5.6 g (13.8 mmol) of 4- [6-fluoro-1- (2 -thiophen-3 -yl-ethyl) -lH-indol-3-yl] - piperidine-1-carboxylic acid ethyl ester. After standard work-up, 4.5 g (99% of yield) of 6-fluoro-3-piperidin-4-yl-l- (2-thiophen-3 -yl-ethyl) -IH-indole were obtained. C. Preparation of 5-{4- [6-fluoro-l- (2 -thiophen-3 -yl-ethyl) - lH-indol-3-yl] -piperidin-1-ylmethyl} -2-methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.3 g (6.9 mmol) of 6- fluoro-3-piperidin-4-yl-l- (2-thiophen-3-yl-ethyl) -lH-indole and 2 g (7.5 mmol) of 3 -bromomethyl-4 -methoxy-benzoic acid ethyl ester. After standard work-up and recrystallisation with methanol, 1 g (29% of yield) of the expected acid were obatined. Melting point 228-229°C NMR (300 MHz, DMSO) 5=1.56-1.67 (m, 2H) , 1.87-1.91 (m, 2H) , 2.10-2.17 (t, 2H) , 2.68-2.76 (m, IH) , 2.88-2.92 (d, 2H) , 2.99-3.05 (t, 2H) , 3.50 (s, 2H) , 3.80 (s, 3H) , 4.29-4.31 (m, 2H) , 6.78.6.85 (m, IH) , 6.99-7.02 (dd, IH) , 7.07-7.10 (m, 2H) , 7.16-7.19 (m, IH) , 7.28-7.32 (m, 2H) , 7.38-7.49 (m, 2H) , 7.51-7.54 (m, IH) , 7.58-7.59 (m, IH) . Example 79 Preparation of 5-{4- [1- (5 -chloro-thiophen-2 -ylmethyl) -6- fluoro-lH-indol-3-yl] -piperidin-1-ylmethyl} -2 -methoxy-benzoic acid A . Preparation of 4 - [1- ( 5 -chloro-thiophen-2 -ylmethyl) - 6 - f luoro- lH- indol-3 -yl] -piperidine- 1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 2.2 g (7.5 mmol) of 4- (6-fluoro-lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester (example 24, part A) and 1.1 mL (8.8 mmol) of 2-chloro- 5 -chloromethyl-thiophene . The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 2.2 g (68% of yield) of 4- [1- (5-chloro-thiophen-2 -ylmethyl) -6- fluoro-lH-indol-3-yl] -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 1- (5 -chloro-thiophen-2 -ylmethyl) -6-fluoro- 3 -piperidin-4 -yl-lH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 4.4 g (10.4 mmol) 4- [1- (5-chloro-thiophen-2-ylmethyl) -6-fluoro-lH-indol-3-yl] - piperidine- 1-carboxylic acid ethyl ester. After standard work-up, 2.4 g (67% of yield) of 1- (5-chloro-thiophen-2- ylmethyl) -6-fluoro-3-piperidin-4-yl-lH-indole were obtained. C. Preparation of 5-{4- [1- (5-chloro- thiophen-2 -ylmethyl) -6- fluoro-IH-indol-3-yl] -piperidin-1-ylmethyl} -2 -methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.4 g (6.9 mmol) of 1- (5 -chloro-thiophen-2 -ylmethyl) -6-fluoro-3-piperidin-4-yl-lH- indole and 2 g (7.5 mmol) of 3 -bromomethyl-4 -methoxy-benzoic acid ethyl ester. After standard work-up, 0.7 g (20% of yield) of the expected acid were obtained. Melting point 232-236°C NMR (300 MHz, DMSO) 5=1.65-1.73 (m, 2H) , 1.90-1.94 (d, 2H) , 2.15-2.22 (t, 2H) , 2.70-2.78 (m, IH) , 2.91-2.95 (m, 2H) , 3.53 (s, 2H) , 3.80 (s, 3H) , 5.45 (s, 2H) , 6.83-6.89 (t, IH) , 6.95- 7.08 (m, 3H) , 7.23 (s, IH) , 7.40-7.44 (m, 2H) , 7.54-7.59 (m, 2H) . Example 80 Preparation of 5- [4- (6-fluoro- l-furan-3 -ylmethyl- lH-indol-3 - yl) -piperidin-1-ylmethyl] -2-methoxy-benzoic acid A. Preparation of 4- (6-fluoro-1-furan-3 -ylmethyl-IH-indol-3 - yl) -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 4 g (13.8 mmol) of 4- (6- fluoro-lH-indol-3-yl) -piperidine-r-carboxylic acid ethyl ester (example 24, part A) and 17 L (16 mmol) of a freshly prepared solution 0.94 M in ethyl ether of 3 -bromomethyl- furan. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 5.3 g (99% of yield) of 4- (6-fluoro-l-furan-3-ylmethyl-lH-indol-3-yl) -piperidine-1- carboxylic acid ethyl ester were obtained. B. Preparation of 6-fluoro-1-furan-3 -ylmethyl-3 -piperidin-4- yl-lH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 5.3 g (13.7 mmol) of 4- ( 6-fluoro-1-furan-3 -ylmethyl - IH-indol-3 -yl ) -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 3.5 g (86% of yield) of 6-fluoro-l-furan-3-ylmethyl-3-piperidin-4- yl-lH-indole were obtained. C. Preparation of 5- [4- (6-fluoro- 1-furan- 3 -ylmethyl-IH-indol- 3-yl) -piperidin- 1-ylmethyl] -2-methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.1 g { 6 . 9 mmol) of 6- fluoro-l-furan-3-ylmethyl-3-piperidin-4-yl-lH-indole and 2 g (7.5 mmol) of 3 -bromomethyl-4 -methoxy-benzoic acid ethyl ester. After standard work-up, 0.9 g (28% of yield) of the expected acid were obtained. Melting point 228-229°C NMR (300 MHz, DMSO) 5=1.56-1.73 (m, 2H) , 1.76-1.89 (m, 2H) , 2.11-2.18 (m, 2H) , 2.62-2.82 (m, IH) , 2.90-2.93 (m, 2H) , 3.51 (s, 2H) , 3.81 (s, 3H) , 5.11 (s, 2H) , 6.40 (s, IH) , 6.76-6.92 ( , IH) , 7.07-7.10 (d, IH) , 7.22 (s, IH) , 7.36-7.43 (m, 2H) , 7.46-7.59 (m, 3H) , 7.72 (s, IH) . Example 81 Preparation of 3-{4- [1- (2 -pyridin-2 -yl-ethyl) -lH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid A. Preparation of 4- [1- (2-pyridin-2-yl-ethyl) -lH-indol-3-yl] - piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 11 g (40 mmol) 4- (1H- indol -3-yl) -piperidine-1-carboxylic acid ethyl and 8.6 g (48 mmol) of a freshly prepared 2 -pyridin-2 -yl-ethyl methansulfonate. The reaction mixture was stirred at 60 °C for 18 hours. After standard work-up, 3.2 g (21% of yield) 4- [1- (2-pyridin-2-yl-ethyl) -lH-indol-3-yl] -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 3 -piperidin-4-yl-l- (2-pyridin-2-yl-ethyl) - IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 8.8 g (12.9 mmol) of 4- [1- (2 -pyridin-2 -yl-ethyl) -lH-indol-3-yl] -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 3.4 g (87% of yield) of 3-piperidin-4-yl-l- (2-pyridin-2-yl-ethyl) - IH-indole were obtained. C. Preparation of 3 - {4- [1- (2 -pyridin-2 -yl-ethyl) -lH-indol-3 - yl] -piperidin-1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 3.4 g (11 mmol) of 3- piperidin-4-yl-l- (2 -pyridin-2 -yl-ethyl) -IH-indole and 2.7 g (11.5 mmol) of.3 -bromomethyl-benzoic acid methyl ester. After standard work-up and recrystallisation with dichloromethane/methanol , 1.4 g (29% of ' yield) of the expected acid were obtained. Melting point 141-142 °C NMR (300 MHz, DMSO) 5=1.55-1.72 (m, 2H) , 1.86-1.90 (m, 2H) , 2.11-2.19 (t, 2H) , 2.69-2.74 (m, IH) , 2.88-2.92 (m, 2H) , 3.15-3.20 (t, 2H) , 3.59 (s, 2H) , 4.45-4.50 (t, 2H) , 6.94-7.24 (m, 5H) , 7.37-7.67 (m, 5H) , 7.83-7.86 (m, IH) , 7.94 (s, IH) , 8.51-8.54 (m, IH) . Example 82 Preparation of 5- [4- (6-fluoro-l-thiophen-2-ylmethyl-lH-indol- 3-yl) -piperidin- 1-ylmethyl] -2-methoxy-benzoic acid A. Preparation of 4- (6-fluoro-1-thiophen-2 -ylme hyl-IH-indol- 3-yl) -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 4 g (13.8 mmol) of 4- (6- fluoro-lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester (example 24, part A) and 16 mL of (16 mmol) of a freshly prepared IM solution in ethyl ether of 2 -bromomethyl- thiophene. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 5.42 g (100% of yield) of 4- (6-fluoro-l-thiophen-2-ylmethyl-lH- indol-3-yl) -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 6-fluoro-3-piperidin-4-yl-l-thiophen-2- ylmethyl-IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 9.4 g (13.8 mmol) of 4- (6-fluoro-1-thiophen-2 -ylmethyl- IH-indol-3 -yl ) -piperidine- 1- carboxylic acid ethyl ester. After standard work-up, 2.9 g (69% of yield) of 6-fluoro-3-piperidin-4-yl-l-thiophen-2- ylmethyl- IH-indole were obtained. i C. 5- [4- (6-fluoro-l-thiophen-2-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.9 g (9.2 mmol) of 6- fluoro-3 -piperidin-4 -yl- 1-thiophen-2 -ylmethyl -IH- indole and 2.7 g (11.5 mmol) of 5 -bromomethyl-2 -methoxy-benzoic acid ethyl ester. After standard work-up, 1.2 g (27% of yield) of the expected acid were obtained. Melting point 245-246°C NMR (300 MHz, DMSO) 5=1.60-1.68 (m, 2H) , 1.89-1.93 ('m, 2H) , 2.10-2.18 (t, 2H) , 2.65-2.80 (m, IH) , 2.89-2.93 (d, 2H) , 3.50 (s. 2H) , 3.80 (s, 3H) , 5.50 (s, 2H) , 6.81-6.87 (m, IH) , 6.94- 6 , 96 (m, IH) , 7 . 09 - 7 . 13 (m , 2H) , 7 . 23 ( s , IH) , 7 . 3 6 - 7 . 44 (m, 3H) , 7 . 52 - 7 . 58 (m , 2H) . Example 83 Preparation of 3- [4- (l-furan-2-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid A. Preparation of 4- (l-furan-2-ylmethyl-lH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 9.4 g (34.4 mmol) of 4- (lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester and 40 L of (40 mmol) of a freshly prepared IM solution in ethyl ether of 2 -bromomethyl -furan. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 13.2 g (100% of yield) of 4- (1-furan-2 -ylmethyl-lH- indol-3-yl) -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of l-furan-2-ylmethyl-3-piperidin-4-yl-lH- indole This compound was prepared following the procedure described in example 13 (part C) starting with 13.2 g (37 mmol) of 4- ( 1 -furan-2 -ylmethyl - IH-indol-3 -yl) -piperidine- 1-carboxylic acid ethyl ester. After standard work-up, 10.2 g (98% of yield) of l-furan-2-ylmethyl-3-piperidin-4-yl-lH-indole were obtained. C. 3- [4- (1-furan-2 -ylmethyl-IH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.8 g (10 mmol) of 1- furan-2-ylmethyl-3-piperidin-4-yl-lH-indole and 2.5 g (11 mmol) of 3 -bromomethyl-benzoic acid methyl ester. After standard work-up, 1.5 g (36% of yield) of the expected acid were obtained. Melting point 154-155°C NMR (300 MHz, DMSO) =1.61-1.76 (m, 2H) , 1.90-1.95 (m, 2H) , 2.12-2.20 (t, 2H) , 2.72-2.80 ( , IH) , 2.89-2.92 (m, 2H) , 3.59 (s, 2H) , 5.33 (s, 2H) , 6.37-6.44 (m, 2H) , 6.96-7.01 (m, IH) , 7.08-7.13 (m, 2H) , 7.44-7.57 (m, 5H) , 7.83-7.85 (m, IH) , 7.93 5 (s, IH) . Example 84 Preparation of 2- (2-{4- [1- (2- [1, 4] dioxan-2 -yl-ethyl) -1H- indol-3-yl] -piperidin- 1-yl} -ethoxy) -benzoic acid 10 This compound was prepared following the procedure described in example 13 (part D) starting with 0.5-8 g (1.84 mmol) of 1- (2- [1,4] dioxan-2 -yl-ethyl) -3-piperidin-4-yl-lH-indole (example 71, part B) and 0.51 g (2.39 mmol) of 2- (2-chloro- ethoxy) -benzoic acid methyl ester. After standard work-up and 15. purification by flash chromatography over silica gel, 0.18 g (20% of yield) of the expected acid were obtained. Melting point 139-140°C NMR (300 MHz, DMS =1.70-1.82 ' (m, 2H) , 1 .91-2 .08 (m, 4H), 2.66-2.73 (m, 2H) 2.93-3.10 (m, 3H) , 3. .11-3. .27 (m, 4H) , 20 3 3. .4444--33.. .6644 ( (mm,, 4H) 3.76-3.79 (m, IH) , 4. .18-4. .22 (m, 2H) , 4 .42-4, .46 (m, 2H) 6.97-7.04 (m, 2H) , 7. .12-7. .15 (m, 2H) , 7, .22-7. .25 (m, IH) 7.37-7.41 (m, 2H) , 7. ,52-7. .54 (d,. IH) , 7.64-7.66 (d, IH) . 5 Example 85 Preparation of 5- [4- (1-furan-2 -ylmethyl -IH-indol -3-yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 1.9 g (6.5 mmol) of 1- 0 furan-2-ylmethyl-3-piperidin-4-yl-lH-indole (example 83, part B) and 1.9 g (7.1 mmol) of 5 -bromomethyl -2 -methoxy- benzoic . acid ethyl ester.. After standard work-up and recrystallisation with ethanol, 0.5 g (16% of yield) of the expected acid were obtained. 5 Melting point 237-238°C NMR (300 MHz, DMSO) =1.65-1.75 (m, 2H) , 1.90-1.95 (m, 2H) , 2.11-2.18 (t, 2H) , 2.68-2.83 (m, IH) , 2.89-2.93 (m, 2H) , 3.50 (s, 2H) , 3.81 (s, 3H) , 5.33 (s, 2H) , 6.37-6.44 (m, 2H), " 6.96- 7.17 (m, 4H) , 7.42-7.59 (m, 5H) . Example 86 Preparation of 5- [4- (l-furan-3-ylmethyl-lH-indol-3-yl) - piperidin- 1-ylmethyl] -2-methoxy-benzoic acid A. Preparation of 4- (l-furan-3-ylmethyl-lH-indol-3-yl) - piperidine- 1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 4 g (13.7 mmol) 4-(lH- indol-3-yl) -piperidine-1-carboxylic acid ethyl ester and 16 mL (16 mmol) of a freshly prepared IM solution in ethyl ether of 3 -bromomethyl-furan. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 5.3 g (99% of yield) of 4- (l-furan-3 -ylmethyl-IH-indol -3-yl) - piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of l-furan-3 -ylmethyl-3-piperidin-4-yl-lH- indole This compound was prepared following the procedure described in example 13 (part C) starting with 7.3 g (20 mmol) of 4- (1- furan-3 -ylmethyl-IH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester. After standard work-up, 5.6 g (99% of yield) of l-furan-3-ylmethyl-3-piperidin-4-yl-lH-indole were obtained. C. 5- [4- (1-furan-3 -ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -2-methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 1.9 g (6.5 mmol) of 1- furan-3-ylmethyl-3-piperidin-4-yl-lH-indole and 1.9 g (7.1 mmol) 5 -bromomethyl-2 -methoxy-benzoic acid ethyl ester. After standard work-up, 1.2 g (42% of yield) of the expected acid were obtained. Melting point 253-255°C NMR (300 MHz, DMSO) =1.61-1.78 (m, 2H) , 1.91-1.95 (m, 2H) , 2.08-2.12 (m, 2H) , 2.72-2.82 (m, IH) , 2.91-2.94 (m, 2H) , 3.52-3.62 (m, 2H) , 3.81 (s, 3H) , 5.14 (s, 2H) , 6.38 (s, IH) , 6.95-7.00 (t, IH) , 7.08-7.11 (m, 2H) , 7.21 (s, IH) , 7.44-7.60 (m, 5H) , 7.69 (s, IH) . Example 87 Preparation of 3-{4- [5-methoxy-l- (2 -thiophen-3 -yl-ethyl) -1H- indol-3-yl] -piperidin-l-ylmethyl}-benzoic acid A. Preparation of 5-methoxy-3 -piperidin-4-yl-lH-indole This compound was prepared following the procedure described in example 1 (parts A and B) starting with 5.9 g (40 mmol) of 5-methoxyindol and 15.5 g (100 mmol) of 4-piperidone . In this case the hydrogenation took place for 24 hours at 30 psi and the catalyst used was platinum (IV) oxide. 6.8 g (74% of yield) of 5-methoxy-3-piperidin-4-yl-lH-indole were obtained. B. Preparation of 4- (5-methoxy-lH-indol-3-yl) -piperidine-1- carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part A) starting with 5.8 g (25 mmol) of 5- methoxy-3 -piperidin-4-yl-lH- indole . After standard work-up, 6.9 g (91% of yield) of 4- (5-methoxy-lH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester were obtained. C. Preparation of 4- [5-methoxy-l- (2 -thiophen-3 -yl-ethyl) -1H- indol-3-yl] -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 8.7 g (28.6 mmol) of 4- (5 -methoxy-lH-indol -3-yl) -piperidine-1-carboxylic acid ethyl ester and 6.9 g (33.4 mmol) of 2-thiophen-3-yl-ethyl methansulfonate. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 6.7 g (57% of yield) of 4- [5-methoxy-l- (2-thiophen-3 -yl-ethyl) -lH-indol- 3-yl] -piperidine- 1-carboxylic acid ethyl ester were obtained. D. Preparation of 5 -methoxy-3 -piperidin-4-yl-l- (2 -thiophen-3 - yl-ethyl) -IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 6.6 g (16 mmol) of 4- [5- methoxy-1- (2 -thiophen-3-yl-ethyl) -lH-indol-3-yl] -piperidine- 1-carboxylic acid ethyl ester. After standard work-up, 5.3 g (97% of yield) of 5-methoxy-3-piperidin-4-yl-l- (2-thiophen-3- yl-ethyl) -IH-indole were obtained. E. Preparation of 3 -{4- [5-methoxy-l- (2 -thiophen-3 -yl-ethyl) - lH-indol-3-yl] -piperidin-1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 1.7 g (5 mmol) of 5- methoxy-3-piperidin-4-yl-l- (2-thiophen-3-yl-ethyl) -IH-indole and 1.3 g (5.5 mmol) of 3 -bromomethyl-benzoic acid methyl ester. After standard work-up, 0.8 g (34% of yield) of the expected acid were obtained. Melting point 217-218°C NMR (300 MHz, DMSO) =1.60-1.67 (m, 2H) , 1.88-1.91 (m, 2H) , 2.12-2.20 (t, 2H) , 2.64-2.72 (m, IH) , 2.88-2.92 (m, 2H) , 2.99-3.04 (m, 2H) , 3.59 (s, 2H) , 3.75 (s, 3H) , 4.25-4.30 (m, 2H) , 6.71-6.75 (m, IH) , 6.96-7.02 (m, 3H) , 7.14-7.16 (m, IH) , 7.31-7.34 (d, IH) , 7.42-7.48 (m, 2H) , 7.56-7.58 (d, IH) , 7.83-7.85 (d, IH) , 7.93 (s, IH) . Example 88 Preparation of 2- (2-{4- [5-methoxy-l- (2 -thiophen-3 -yl-ethyl) - lH-indol-3-yl] -piperidin-l-yl}-ethoxy) -benzoic acid This compound was prepared following the procedure described in example 87 (part E) starting with 1.7 g (5 mmol) of 5- methoxy-3-piperidin-4-yl-l- (2 -thiophen-3 -yl-ethyl) -IH-indole and 1.2 g (5.5 mmol) of 2- (2-chloro-ethoxy) -benzoic acid methyl ester. After standard work-up and purification by flash chromatography, 0.6 g (24% of yield) of the expected acid were obtained. Melting point 145-148°C NMR (300 MHz, DMSO) = 1.94-2.03 (m, 4H) , 2.64-2.67 (m, 2H) , 2.82-2.87 (m, IH) , 2.98-3.05 (m, 4H) , 3.21-3.25 (m, 2H) , 3.80 (s, 3H) , 4.27-4.32 (m, 2H) , 4.46 (s, 2H) , 6.73-6.77 (dd, IH) , 6 . 99 - 7 . 04 (m , 3H) , 7 . 13 ( s , IH) , 7 . 19 - 7 . 22 (m , 2H) , 7 . 33 - 7 . 37 (m, 2H) , 7 . 40 - 7 . 51 (m, IH) , 7 . 533 - 7 . 58 ( , IH) . Example 89 Preparation of 2-{2- [4- (5-me hoxy- 1-thiophen-2 -ylmethyl-1H- indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid A. Preparation of 4- (5 -methoxy-1-thiophen-2 -ylmethyl-1H- indol-3-yl) -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 9.1 g (30 mmol) of 4- (5- methoxy-lH-indol-3-yl) -piperidine- 1-carboxylic acid ethyl ester (example 87, part B) and 50 mL (50 mmol) of a freshly prepared IM solution in ethyl ether of 2 -bromomethyl - thiophene. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 7.7 g (65% of yield) of 4- (5-methoxy-l-thiophen-2 -ylmethyl -lH-indol-3- yl) -piperidine- 1-carboxylic acid ethyl ester were obtained. B. Preparation of 5-methoxy-3 -piperidin-4-yl-l-thiophen-2 - ylmethyl-IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 7.7 g (19 mmol) of 4- (5- ethoxy-1-thiophen-2 -ylmethyl-IH-indol-3 -yl) -piperidine- 1- carboxylic acid ethyl ester. After standard work-up, 5 g (81% of yield) of 5-methoxy-3 -piperidin-4-yl-l-thiophen-2- ylmethyl-IH-indole were obtained. C. Preparation of 2 -{2- [4- (5 -methoxy-1-thiophen-2 -ylmethyl- 1H-indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.4 g (7.4 mmol) of 5- methoxy-3-piperidin-4-yl-l-thiophen-2-ylmethyl-lH-indole and 1.8 g (8 mmol) of 2- (2-chloro-ethoxy) -benzoic acid methyl ester. After standard work-up, 1.3 g (36% of yield) of the expected acid were obtained. Melting point 150-151°C NMR (300 MHz, DMSO) = 1.94-2.10 (m, 4H) , 2.63-2.70 (m, 2H) , 2.86-2.98 (m, 3H) , 3.22-3.26 (m, 2H) , 3.79 (s, 3H) , 4.44-4.47 (m, 2H) , 4.80-5.25 (m, IH) , 5.50 (s, 2H) , 6.74-6 ' .77 (dd, IH) , 6.93-7.24 (m, 6H) , .7.35-7.41 (m, 2H) , 7.50-7.53 (dd, IH) . Example 90 Preparation of 3 - [4- (5-methoxy-l.-thiophen-2 -ylmethyl-1H- indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 2.4 g (7.4 mmol) of 5- methoxy-3 -piperidin-4 -yl- 1-thiophen-2 -ylmethyl - IH-indole (example 89, part C) and 1.9 g (8 mmol) 3 -bromomethyl-benzoic acid methyl ester. After standard work-up, 1.4 g (41% of yield) of the expected acid were obtained. Melting point 185-186°C • NMR (300 MHz, DMSO) = 1.60-1.76 (m, 2H) , 1.91-1.95 (m, 2H) , 2.16-2.23 (m, 2H) , 2.70-2.78 (m, IH) , 2.91-2.94 ( , 2H) , 3.56 (s, 2H) , 3.74 .(s, 3H) , 5.47 (s, 2H) , 6.72-6.76 (dd, IH) , 6.92-6.95 (m, IH) , 7.01-7.02 (m, IH) , 7.06-7.07 (m, IH) , 7.20 (s, IH) , 7.33-7.60 (m, 4H) , 7.84-7.86 (d, IH) , 7.94 (s, IH) . Example 91 Preparation of 2 -methoxy-5-{4- [5-methoxy-l- (2-thiophen-3 -yl- ethyl) -lH-indol-3-yl] -piperidin- 1-ylme.thyl} -benzoic acid This compound was prepared following the procedure described in example 13 (part: D) starting with 1.95 g (5.7 mmol) of 5- methoxy-3 -piperidin-4 -yl -1-thiophen-2 -ylmethyl -IH-indole (example 87, part E) and 1.7 g (6.2 mmol) of 5 -bromomethyl -2 - methoxy-benzoic acid ethyl ester. After standard work-up, 1 g (35% of yield) of the " expected acid were obtained. Melting point 229-230°C NMR ' (300 MHz, DMSO) = 1.55-1.66 (m, 2H) , 1.87-1.92 (m, 2H) , 2.08-2.16 (m, 2H) , 2.53-2.74 (m, IH) , 2.87-2.91 (m, 2H) , 2.99-3.04 (m, 2H) , 3.48 (s, 2H) , 3.75 (s, 3H) , 3.81 (s, 3H) , 4.25-4.30 (t, 2H) , 6.72-6.75 (d, IH) , 6.96-7.01 (m, 3H) , 7- 07 - 7 - 10 ( d , IH) , 7 . 16 ( s , IH) , 7 . 32 - 7 . 34 ( d , IH) , 7 . 42 - 7 . 45 (m , 3H) , 7 . 58 ( s , IH) . Example 92 Preparation of 2-{2- [4- (l-furan-3 -ylmethyl-5 -methoxy- 1H- indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid A. Preparation of 4- (l-furan-3 -ylmethyl-5 -methoxy-IH-indol-3- yl) -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) starting with 8 g (26.4 mmol) of 4- (5- methoxy-lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester (example 87, part B) and 30 mL (30 mmol) of a freshly prepared IM solution in ethyl ether of 3 -bromomethyl-furan. The reaction mixture was stirred at room temperature for 18 hours. After standard work-up, 9.9 g (99% of yield) of 4- (1- furan-3 -ylmethyl-5 -methoxy-IH-indol -3 -yl) -piperidine-1- carboxylic acid ethyl ester were obtained. B. Preparation of l-furan-3-ylmethyl-5-methoxy-3-piperidin-4- yl- IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 9.9 g (25.8 mmol) of 4- ( 1 -furan-3 -ylmethyl-5-methoxy-IH-indol -3 -yl) -piperidine- 1- carboxylic acid ethyl ester. After standard work-up, 7.5 g (94% of yield) of l-furan-3 -ylmethyl-5 -methoxy-3-piperidin-4- yl-IH-indole were obtained. C. Preparation of 2-{2- [4- (l-furan-3 -ylmethyl- 5 -methoxy-1H- indol-3 -yl) -piperidin-1-yl] -ethoxy} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 3.7 g (11.9 mmol) of 1- furan-3-ylmethyl-5-methoxy-3-piperidin-4-yl-lH-indole and 3 g (13.9 mmol) of 2- (2-chloro-ethoxy) -benzoic acid methyl ester. After standard work-up, 3.2 g (57% of yield) of the expected acid were obtained. Melting point 153-154°C NMR (300 MHz, DMSO) =1.86-2.02 (m, 4H) , 2.63-2.69 (m, 2H) , 2.79-2.99 (m, 3H) , 3.21-3.26 (m, 2H) , 3.79 (s, 3H) , 4.43-4.47 (m, 2H) , 5.12 (s, 2H) , 6.38 (s, IH) , 6.73-6.76 (dd, IH) , 6.99-7.04 (t, IH) , 7.15-7.16 (m, 2H) , 7.22-7.25 (d, IH) , 7.35-7.40 (m, 2H) , 7.50-7.52 (d, IH) , 7.56 (s, IH) , 7.69 (s, IH) . Example 93 Preparation of 3- [4- (l-furan-3 -ylmethyl- 5 -methoxy-lH-indol-3- yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 3.7 g (11.9 mmol) of 1- furan-3 -ylmethyl -5 -methoxy-3 -piperidin-4 -yl-IH-indole (example 92, part B) and 3 g (13 mmol) of 3 -bromomethyl - benzoic acid methyl ester. After standard work-up, 2.4 g (45% of yield) of the expected acid were obtained. In this case a p-tolensulfonate derivative salt was prepared affording 2.9 g of white solid. Melting point 214-215°C NMR (300 MHz, DMSO) =1.78-1.91 (m, 2H) , 2.13-2.18 (m, 2H) , 2.28 (s, 3H) , 2.94-3.12 (m, 3H) , 3.46-3.49 (d, 2H) , 3-.75 (s, 3H) , 4.45 (s, 2H) , 5.12 (s, 2H) , 6.34 (s, IH) , 6.76-6.79 (dd, IH) , 7.10-7.18 (s, 4H) , 7.39-7.66 (m, 6H) , 7.79-7.81 (d, IH) , 8.04-8.06 (d, IH) , 8.20 (s, IH) . Example 94 Preparation of 2- [4- (1-furan-2 -ylmethyl-IH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.05 g (0.18 mmol) of l-furan-2-ylmethyl-3-piperidin-4-yl-lH-indole (example 83, part B) and 0.056 g (0.23 mmol) of 2 -bromomethyl-benzoic acid ethyl ester. After standard work-up and purification using a C18 chromatography column, 0.014 g (19% of yield) of the expected acid were obtained. NMR (300 MHz, CDCl 3 ) = 1.91-2.03 (m, 2H) , 2.13-2.18 (m, 2H) , 2.55-2.68 (m, 2H) , 2.95-3.30 (m, IH) , 3.26-3.30 (m, 2H) , 3.98 (s, 2H) , 5.18 " (m, 2H) , 6.24-6.25 (d, IH) , 6.30-6.31 (m, IH) , 6.90 (s, IH) , 7.08-7.13 (t, IH) , 7.20-7.50 (m, 6H) , 7.54-7.56 (d, IH) , 8.19-8.22 (dd, IH) . Example 95 Preparation of 2- [4- (6-fluoro-1- uran-2 -ylmethyl-lH-indol-3- yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.3 g (1.0 mmol) of 4- (6-fluoro-lH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester and 2.7 mL (1.6 mmol) of a freshly prepared 0.61 M solution of 2- bromomethylfuran in ethyl ether. After standard work-up, 0.38 g (100% of yield) of 4- (6-fluoro- 1-furan-2 -ylmethyl-lH-indol- 3-yl) -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 6-fluoro- l-furan-2-ylmethyl-3 -piperidin-4- yl- IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 0.38 g (1.1 mmol) of 4- (6-fluoro-1-furan-2 -ylmethyl -IH-indol-3 -yl) -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 0.27 g (89% of yield) of 6-fluoro-l-furan-2-ylmethyl-3-piperidin-4- yl-IH-indole were obtained. C. Preparation of 2 - [4- (6-fluoro-l-furan-2-ylmethyl-lH-indol- 3-yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.05 g (0.17 mmol) and 0.054 g (0.22 mmol) of 2 -bromomethyl-benzoic acid ethyl ester. After standard work-up and purification using a C18 chromatography column, 0.021 g (29% of yield) of the expected acid were obtained. NMR (300 MHz, CDCl 3 ) =1.95-2.04 (m, 2H) , 2.18-2.22 (m, 2H) , 2.72-2.88 (m, 3H) , 3.37-3.41 (m, 2H) , 4.10 (s, 2H) , 5.14 (s, 2H) , 6.27-6.28 (d, IH) , 6.31-6.33 (dd, IH) , 6.83-6.90 (td, IH) , 6.93 (s, IH) , 7.07-7.11 (dd, IH) , 7.23-7.26 (d, IH) , 7.36-7.53 (m, 4H) , 8.11-8.14 (dd, IH) . Examples 96 and 97 These compounds were prepared following the procedure described in example 95. The ESI/MS data, yields and purity are summarised in table 13. Table 13. Examples 96-97 Example 98 Preparation of 4-methoxy-2- [4- (5-methoxy-l-thiophen-2 - ylmethyl-IH-indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.06 g (0.19 mmol) of 5- methoxy-3 -piperidin-4 -yl- 1-thiophen-2 -ylmethyl-IH-indole (example 89, part B) and 0.064 g - (0.23 mmol) of 2- bromomethyl-4 -methoxy-benzoic acid methyl ester. After standard work-up and purification by chromatography using a C18 column, 0.018 g (19% of yield) of the expected acid were obtained. NMR (300 MHz, DMSO) =1.58 -1.72 (m, 2H) , 2.07-2.11 (m, 2H) , 2.69-2.77 (t, 2H) , 2.82-3.11 (m, 3H) , 3.76 (s, 3H) , 3.81 (a, 3H) , 4.02 (s, 2H) , 5.49 (s, 2H) , 6.76-6.79 (dd, IH) , 6.92- 6.99 (m, 3H) , 7.06 (s, IH) , 7.35-7.05 (m, 2H) , 7.88-7.91 (d, IH) . Examples 99 - 100 These compounds were prepared following the procedure described in example 98. The ESI/MS data, yields and purity are summarised in table 14. Example 101 Preparation of 2- [4- (l-furan-2-ylmethyl--5-methoxy-lH-indol-3- yl) -piperidin-1-ylmethyl] - -methoxy-benzoic acid A. Preparation of 4- (l-furan-2 -ylmethyl- 5 -methoxy-lH-indol-3- yl) -piperidine-1-carboxylic acid ethyl ester ' This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.3 g (1.0 mmol) of 4- (5-methoxy-lH-indol-3- yl) -piperidine-1-carboxylic acid ethyl ester and 2.11 mL (1.3 mmol) of a freshly prepared 0.61 M solution of 2- bromomethylfuran in ethyl ether. After standard work-up, 0.38 g . (100% of yield) of 4- (l-furan-2 -ylmethyl -5 -methoxy-lH- indol-3-yl) -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 1-furan-2 -ylmethyl-5 -methoxy-3 -piperidin-4- yl- IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 0.38 g (1.1 mmol) of 4- (1-furan-2 -ylmethyl-5 -methoxy-IH-indol -3 -yl) -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 0.27 g (86% of yield) l-furan-2-ylmethyl-5-methoxy-3-piperidin-4-yl- IH-indole were obtained. C. Preparation of 2- [4- (l-furan-2-ylmethyl-5-methoxy-lH- indol-3-yl) -piperidin- 1-ylmethyl] -4 -methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.05 g (0.17 mmol) of 1- furan-2 -ylmethyl-5-methoxy-3 -piperidin-4 -yl-IH-indole and 0.057 g (0.22 mmol) of 2-bromomethyl-4 -methoxy-benzoic acid methyl ester. After standard work-up and purification by chromatography using a C18 column, 0.029 g (36% of yield) of the expected acid were obtained. NMR (300 MHz, DMSO) =1.64-1.75 ( , 2H) , 2.07-2.12 (m, 2H) , 2.75-2.83 (m, 2H) , 2.88-3.00 (m, IH) , 3.12-3.16 (d, 2H) , 3.76 (s, 3H) , 3.82 (s, 3H) , 4.08 (s, 2H) , 5.29 (s, 2H) , 6.37-6.43 (m, 2H) , 6.76-6.80 (dd, IH) , 6.99-7.07 (m, 2H) , 7.18 (s, IH) , 7.40-7.43 (d, IH) , 7.55 (s, IH) , 7.90-7.93 (s, IH) . Examples 102-105 These compounds were prepared following the procedure described in example 101. The ESI/MS data, yields and purity are summarised in table 15. Table 15. Examples 102-105 Example 106 Preparation of 4-methoxy-2 -{4- [5-methoxy-l- (2 -thiophen-3 -yl- ethyl) -lH-indol-3-yl] -piperidin-1-ylmethyl} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.05 g (0.16 mmol) of 5- methoxy-3-piperidin-4-yl-l- (2 -thiophen-3 -yl-ethyl) -IH-indole (example 87, part D) and 0.054 g (0.21 mmol) of 2- bromomethyl-4-methoxy-benzoic acid methyl ester. After standard work-up and purification by chromatography using a 5 C18 column, 0.019 g (24% of yield) of the expected acid were obtained. NMR (300 MHz, DMSO) =1.59-1.71 (m, 2H) , 2.04-2.08 (m, 2H) , 2.69-2.77 (m, 2H) , 2.89-3.10 (m, 5H) , 3.77 (s, 3H) , 3.81 (s, 3H) , 4.02 (s, 2H) , 4.26-4.31 (t, 2H) , 6.74-6.77 (dd, IH) , 0 6.97-7.01 (m, 3H) , 7.04-7.05 (d, IH) , 7.08 (s, IH) , 7.15-7.18 (m, IH) , 7.34-7.37 (d, IH) , 7.43-7.45 (dd, IH) , 7.88-7.91 (d, IH) .- Example 107 5 Preparation of 2-{2- [4- (6-fluoro-1-thiophen-2 -ylmethyl-lH- indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.1 g (0.33 mmol) of 6- fluoro-3 -piperidin-4 -yl-1-thiophen-2 -ylmethyl-IH-indole 0 (example 82, part B) and 0.092 g (0.42 mmol) 2- (2-chloro- ethoxy) -benzoic acid acid methyl ester. The crude mixture was purified by HPLC-MS using a C-18 column. NMR (300 MHz, DMSO) = 1.86-2.10 (m, 4H) , 2.73-2.80 (m, 2H) , 2.90-2.99 (m, IH) , 3.05-3.12 (m, 2H) , 3.30-3.34 (m, 2H) , 5 4.40-4.48 (m, 2H) , 5.53 (s, 2H) , 6.83-6.90 (td, IH) , 6.95- 6.98 (td, IH) , 7.00-7.05 (t, IH) , 7.14-7,15 (m, IH) , 7.21- 7.26 (m, 2H) , 7.39-7.44 (m, 3H) , 7.55-7.58 (m, IH) , 7.64-7.69 (dd, IH) . 0 Example 108 Preparation of 5 - [4 - ( 6 - f luoro - l- thiophen- 3 -ylmethyl- lH- indol- 3 -yl) -piperidin- 1-ylmethyl] - 2 -methoxy-benzoic acid A . Preparation of 4- ( 6 - f luoro-l- thiophen-3 -ylmethyl -lH-indol -3 - yl) -piperidine- 1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.1 g (0.34 mmol) of " 4- (6-fluoro-lH-indol-3- yl) -piperidine-1-carboxylic acid ethyl ester and 0.77 mL (0.45 mmol) of a freshly prepared 0.58 M solution of 3- bromomethylthiophene in ethyl ether. After standard work-up, 0.13 g (100% of yield) 4- (6-fluoro-1-thiophen-3 -ylmethyl -1H- indol-3-yl) -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 6-fluoro-3 -piperidin-4-yl-l-thiophen-3 - ylmethyl-IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 0.13 g (0.34 mmol) of ) 4- (6-fluoro-l-thiophen-3-ylmethyl-lH-indol-3-yl) -piperidine- 1-carboxylic acid ethyl ester. After standard work-up, 0.12 g (99% of yield) 6-fluoro-3-piperidin-4-yl-l-thiophen-3 - ylmethyl-IH-indole were obtained. C. 5- [4- (6-fluoro-l-thiophen-3-ylmethyl-lH-indol-3-yl) - piperidin-1-ylmethyl] -2-methoxy-benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.12 g (0.34 mmol) of 6- fluoro-3 -piperidin- -yl-1-thiophen-3 -ylmethyl-IH-indole and 0.11 g (0.44 mmol) of 5-bromomethyl -2 -methoxy-benzoic acid ethyl ester. The crude mixture was purified by HPLC-MS using a C-18 column. NMR (300 MHz, DMSO) =1.03-1.15 (m, 2H) , 1.25-1.31 (m, 2H) ', 1.78-2.10 (m, 2H) , 2.69-2.81 (m, IH) , 3.00-3.16 (m, 2H) , 3.79-3.83 (m, 5H) , 5.29 (s, 2H) , 6.79-6.86 (t, IH) , 6.99-7.01 (d, IH) , 7.09-7.15 (m, 2H) , 7.38-7.46 (m, 3H) , 7.59-7.64 (m, 2H) , 7.72 (s, IH) . Example 109 Preparation of 2-{2- [4- (6-fluoro-l-thiophen-3-ylmethyl-lH- indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.98 g (0.31 mmol) of 6- fluoro-3 -piperidin-4 -yl- 1-thiophen-3 -ylmethyl -IH-indole (example 108, part B) and 0.09 g (0.40 mmol) 2- (2-chloro- ethoxy) -benzoic acid methyl ester. The crude mixture was purified by HPLC-MS using a C-18 column. NMR (300 MHz, DMSO) =1.90-2.10 (m, 4H) , 2.62-2.71 (m, 2H) , 2.78-3.10 (m, 3H) , 3.22-3.26 (d, 2H) , 4.34-4.39 (m, 2H) , 5.30 (s, 2H) , 6.82-6.88 (t, IH) , 6.99-7.04 (m, 2H) , 7.22-7.28 (m, 2H) , 7.37-7.47 ( , 4H) , 7.53-7.55 (d, IH) , 7.64-7.69 (dd, IH) . Example 110 Preparation of 2- (2-{4- [6-fluoro-1- (2 -thiophen-3 -yl-ethyl) - IH-indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.1 g (0.31 mmol) of 6- fluoro-3-piperidin-4-yl-l- (2 -thiophen-3 -yl-ethyl) -IH-indole (example 78, part B) and 0.09 g (0.42 mmol) of 2-(2-chloro- ethoxy) -benzoic acid ethyl ester. After purification by HPLC- MS using a C-18 column, 0.01 g (99% of purity) of 2-(2-{4-[6- fluoro-1- (2-thiophen-3-yl-ethyl) -lH-indol-3-yl] -piperidin-1- yl} -ethoxy) -benzoic acid were obtained. NMR (300 MHz, DMSO) = 1.84-2.02 (m, 4H) , 2.77-2.87 (m, 3H) , 3.01-3.06 (t, 2H) , 3.10-3.18 (m, 2H) , 4.29-4.34 (t, 2H) , 4.42-4.46 (m, 2H) , 6.79-6.88 (td, IH) , 7.01-7.07 (m, 2H) , 7.10 (s, IH) , 7.20-7.25 (m, 2H) , 7.32-7.35 (dd, IH) , 7.41- 7.47 (m, 2H) , 7.57-7.65 (m, 2H) . Examples 111-112 These compounds were prepared following the procedure described in example 110 using the suitable halides . The ESI/MS data and purity " are summarised in table 16. Table 16. Examples 111-112 Example 113 Preparation of 2-{2- [4- (5-methoxy-1-thiophen-3 -ylmethyl-1H- indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid A. Preparation of 4- (5-methoxy-l-thiophen-3-ylmethyl-lH- indol-3-yl) -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 4 g (13.2 mmol) of 4- (5 -methoxy-IH-indol -3-yl) - piperidine-1-carboxylic acid_ ethyl ester and 2.65 g (15 mmol) of 3 -bromomethylthiophene . After standard work-up, 4.5 g (87% of yield) of 4- (5-methoxy-l-thiophen-3-ylmethyl-lH-indol-3- yl) -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 5-methoxy-3 -piperidin-4-yl-l- thiophen-3 - ylmethyl-IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 4.5 g (11.2 mmol) of 4- (5 -methoxy-1-thiophen-3 -ylmethyl -IH-indol-3-yl) -piperidine-1- carboxylic acid ethyl ester. After standard work-up, 3.4 g (93% of yield) of 5-methoxy-3-piperidin-4-yl-l-thiophen-3 - ylmethyl-IH-indole were obtained. C. Preparation of 2-{2- [4- (5-methoxy-l-thiophen-3-ylmethyl- lH-indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 3.3 g (10 mmol) of 5- methoxy-3-piperidin-4-yl- l-thiophen-3 -ylmethyl -IH-indole and 2.6 g (12 mmol) of 2- (2-chloro-ethoxy) -benzoic acid ethyl ester. After standard work-up and recrystallisation with ethanol, 1.8 g (37 % of yield) of the expected acid were obtained. NMR (300 MHz, DMSO) =1.82 -2 .02 (m, 4H) , 2.62-2.69 (t, 2H) , 2.79-2.98 (m, 3H) , 3.21-3.25 (d, 2H) , 3.79 (s, 3H) , 4.43-4.47 (s, 2H) , 5.38 (s, 2H) , 6.72-6.75 (dd, IH) , 6.97-7.04 (m, 2H) , 7.15 (s, IH) , 7.22-7.25 (m, 2H) , 7.37-7.38 (m, 3H) , 7-40-7.46 (m, IH) , 7.50-7.53 (dd, IH) . Examples 114-116 These compounds were prepared following the procedure described in example 113 using 0.3 mmol of the suitable indols and halides. The crude mixtures were purified by HPLC- MS using a C-18 columnn. The ESI/MS data and purity are summarised in table 17. Table 17. Examples 114-116 Example 117 Preparation of 2-methoxy-5- [4- (1-thiophen-3 -ylmethyl- 1H- indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid A. Preparation of 4- (l-thiophen-3-ylmethyl-lH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.2 g (0.73 mmol) of 4- (IH-indol-3-yl) - piperidine-1-carboxylic acid ethyl ester and 1.64 mL (0.95 mmol) of a freshly prepared 0.6 M solution of 3- brorαo ethylthiophene in ethyl ether. After standard work-up, 0.27 g (100% of yield) of 4- (l-thiophen-3-ylmethyl-lH-indol- 3-yl) -piperidine-1-carboxylic acid ethyl ester were obtained. B. Preparation of 3 -piperidin-4 -yl-1-thiophen-3 -ylmethyl-IH- indole This compound was prepared following the procedure described in example 13 (part C) starting with 0.27 g (0.73 mmol) of 4- (l-thiophen-3-ylmethyl-lH-indol-3-yl) -piperidine-1-carboxylic acid ethyl ester. After standard work-up, 0.22 g (100% of yield) of 3-piperidin-4-yl-l-thiophen-3-ylmethyl-lH-indole were obtained. C. Preparation of 2 -methoxy-5- [4- (1-thiophen-3 -ylmethyl-1H- indol-3-yl) -piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.1 g (0.38 mmol) of 3- piperidin-4-yl-l-thiophen-3-ylmethyl-lH-indole and 0.13 g (0.48 mmol) of 5-bromomethyl-2 -methoxy-benzoic acid ethyl ester. The crude mixture was purified by HPLC-MS using a C-18 column, and 0.002 g (94% of purity) of the expected acid were isolated. NMR (300 MHz, DMSO) =1.06-1.31 (m, 4H) , 1.98-2.18 (m, 2H) , 2.60-2.78 (m, IH) , 2.85-2.99 (m, 2H) , 3.84 (s, 3H) , 3.89-4.05 (m, 2H) , 5.32 (s, 2H) , 6.96-7.00 (m, 2H) , 7.05-7.18 ( , 3H) , 7.37 (s, IH) , 7.43-7.49 (m, 2H) , 7.63-7.78 (m, 3H) . Example 118' Preparation of 3- [4- (1-thiophe -3 -ylmethyl- lH-indol-3 -yl) - piperidin-1-ylmethyl] -benzoic acid This compound was prepared following the procedure described in example 117 (part C) starting with 0.1 g (0.38 mmol) of 3- piperidin-4-yl-l-thiophen-3-ylmethyl-lH-indole and 0.1 g (0.48 mmol) of 3-bromomethyl-benzoic acid methyl ester. The crude mixture was purified by HPLC-MS using a C-18 column, and 0.005 g (98% of purity) of the expected acid were isolated. Example 119 Preparation of 5-{4- [1- (5-chloro-thiophen-2-ylmethyl) -5- e hoxy-IH-indol-3-yl] -piperidin-1-ylmethyl} -2 -methoxy- benzoic acid A. Preparation of 4- [1- (5 -chloro-thiophen-2 -ylmethyl) -5- methoxy-IH-indol-3-yl] -piperidine-1-carboxylic acid ethyl ester This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.1 g (0.33 mmol) of 4- (5 -methoxy-IH-indol-3- yl) -piperidine-1-carboxylic acid ethyl ester and 0.052 mL (0.43 mmol) of 2-chloro-5-chloromethyl-thiophene . After standard work-up, 0.06 g (44% of yield) of 4- [1- (5-chloro- thiophen-2 -ylmethyl) -5-methoxy-lH-indol-3-yl] -piperidine-1- carboxylic acid ethyl ester were obtained. B. Preparation of 1- (5-chloro-thiophen-2 -ylmethyl) -5-methoxy- 3 -piperidin-4-yl-IH-indole This compound was prepared following the procedure described in example 13 (part C) starting with 0.06 g (0.15 mmol) of 4- [1- (5-chloro-thiophen-2-ylmethyl) -5-methoxy-IH- indol-3-yl] - piperidine-1-carboxylic acid ethyl ester. After standard work-up, 0.05 g (89% of yield) 1- (5-chloro-thiophen-2- ylmethyl) -5-methoxy-3-piperidin-4-yl-lH-indole were obtained. C. Preparation of 5-{4- [1- (5-chloro-thiophen-2-ylmethyl) -5- methoxy-IH-indol-3 -yl] -piperidin-1-ylmethyl} -2 -methox - benzoic acid This compound was prepared following the procedure described in example 13 (part D) starting with 0.05 g (0.13 mmol) 1- (5- chloro-thiophen-2 -ylmethyl) -5-methoxy-3 -piperidin-4 -yl-IH- indole and 0.05 g (0.18 mmol) of 5-bromomethyl-2 -methoxy- benzoic acid ethyl ester. The crude mixture was purified by HPLC-MS using a C-18 column, and 0.002 g (99% of purity) of the expected acid were isolated. NMR (300 MHz, DMSO) =1.78-1.85 (m, 2H) , 1.92-1.99 (m, 2H) , 2.31-2.48 (m, 2H) , 2.72-2.85 (m, IH) , 3.03-3.06 (m, 2H) , 3.70-3.74 (m, 5H) , 3.81 (s, 3H) , 5.44 (s, 2H) , 6.67-6.77 (m, IH) , 6.93-6.96 (m, IH) , 7.05-7.11 (m, 3H) , 7.20 (s, IH) , 7.37-7.40 (d, IH) , 7.51-7.54 (d, IH) , 7.64 (s, IH) . Examples 120-121 These compounds were prepared following the procedure described in example 119 with the corresponding halides. The crude mixtures were purified by flash chromatography using a C-18 columnn. The ESI/MS data and purity are summarised in table 18. Table 18. Examples 120-121 Example 122 Preparation of a pharmaceutical composition: Syrup 1000 bottles (150 ml volume) each containing a solution of 750 mg of 2- (2- {4- [1- (2- [1 , 3] dioxolan-2 -yl-ethyl) -6-fluoro- lH-indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid were prepared as follows: 2- (2-{4- [1- (2- [l,3]dioxolan-2-yl-ethyl) -6- fluoro-lH-indol-3-yl] -piperidin-1-yl } -ethoxy) - benzoic acid 750 g glycerin 15,000 g hydrogenated castor oil-ethylene oxide 1,500 g sodium methyl p-hydroxybenzoate 240 g sodium propyl p-hydroxybenzoate 60 g sodium saccharin 300 g flavouring q.s sodium hydroxide q.s. pH = 4 demineralised water q.s. 150 litres Procedure : To a solution of the sodium methyl (and propyl) p- hydroxybenzoates and sodium saccharin in 30 litres of demineralised water, an aqueous glycerin solution and hydrogenated castor oil-ethylene oxide was added. After stirring, the 2- (2- {4- [1- (2- [1, 3] dioxolaή-2-yl-ethyl) -6- fluoro-lH-indol-3-yl] -piperidin-1-yl} -ethoxy) -benzoic acid was added and homogenized to reach complete dissolution. After this, the flavouring agent was mixed into the solution with vigorous stirring, and the mixture was made up to final volume with demineralised water. The resultant solution was filled into 150 ml bottles using an appropriate filling machine. Example 123 Preparation of a pharmaceutical composition: capsules 50,000 capsules each containing 50 mg of 2- {2- [4- (1-thiophen- 2 -ylmethyl-IH-indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid were prepared from the following formulation: 2- {2- [4- (l-thiophen-2-ylmethyl-lH-indol-3-yl) -piperidin-1- yl] -ethoxy} -benzoic acid 2,500 g magnesium stearate 225 g lactose spray dried 18,350 g cross-linked sodium carboxymethylcellulose 900 g sodium lauryl sulphate 450 g Procedure : The 2-{2- [4- (l-thiophen-2-ylmethyl-lH-indol-3 -yl) -piperidin- 1-yl] -ethoxy} -benzoic acid, sodium lauryl sulphate, lactose and cross-linked sodium carboxymethylcellulose were mixed together and passed through a screen with an opening of 0.6 mm. The magnesium stearate was added and the mixture encapsulated into gelatine capsules of appropriate size. Example 124 Preparation of a pharmaceutical composition: tablets 100,000 tablets each containing 25 mg of 2- {2- [4- (1-pyridin- 4-ylmethyl-IH-indol-3-yl) -piperidin-1-yl] -ethoxy} -benzoic acid were prepared from the following formulation: 2- {2- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid 2,500 g microcrystalline cellulose 1,650 g lactose spray dried 9,620 g carboximethyl starch 570 g sodium stearyl fumarate 80 g colloidal silicon dioxide 80 g Procedure : All the powders were passed through a screen with apertures of 0.6 mm. They were then all mixture in a suitable mixer for 30 minutes and compressed into 145 mg tablets using 6 mm discs and flat bevelled punches. The desintegration time of the tablets was about 60 seconds.

Claims: CLAIMS A compound of formula (I) wherein: A 1 represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or hydroxyalkylene group; represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or an alkyleneoxyalkylene group; W 1 represents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; W^ represents a 3-10 membered monocyclic "or bicyclic group containing from 1 to 3 heteroatoms said group being unsubstituted or substituted by one or more halogen atoms, alkyl groups, alkoxy groups and/or oxo groups ; R 1 represents a hydrogen or halogen atom or an alkyl, alkoxy or methylamino group; and R^ represents a carboxyl group; and pharmaceutically acceptable salts thereof. 2. A compound according to claim 1 wherein A 1 represents a C^ alkylene or C_. s alkyleneoxy group. 3. A compound according to claim 1 or 2 wherein A 2 represents a C__ 5 alkylene, C x . s alkanoylene, C 2 . 5 alkyleneoxy, C 2 . s alkylenethio or C 2 . s alkyleneoxy-C^ alkylene group. 4. A compound according to any one of claims 1 to 3 wherein W 1 represents an unsubstituted phenylene, furanylene or pyridinylene group or a phenylene group substituted by one or two substituents selected from fluorine atoms, chlorine atoms, bromine atoms, methyl groups and methoxy groups. 5. A compound according to any one of claims 1 to 4 wherein the heteroatom(s) contained in the substituent W 2 are selected from oxygen, sulphur and nitrogen. 6. A compound according to claim 5 wherein W 2 represents a dioxolanyl, dioxanyl, pyrazolidinyl, isoindolinyl benzodioxolanyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, furanyl , thienyl, pyrrolyl, pyridinyl, imidazolyl, dihydrothiazolyl, benzothiazolyl, pyrrolidinyl, benzooxazolyl, benzothienyl, pyranyl, benzofuranyl , isobenzylfuranyl, chromenyl, pyrazolyl, oxazolyl, isooxazolyl, furazanyl, isochromanyl, chromanyl , pyrrolinyl, imidazolidinyl , imidazolinyl, pyrazolinyl, piperidyl, piperazinyl, indolinyl, morpholinyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolizinyl, isoindolyl, indolyl, indazolyl, quinazolinyl, isoquinazolinyl , quinolyl , phthalazinyl, naphthyridinyl , quinoxalinyl, quinazolinyl or cinnolinyl group which is unsubstituted or substituted by one or more halogen atoms, C x . 7 alkyl groups, C x . 7 alkoxy groups and/or oxo groups . 7. A compound according to claim 6 wherein W 2 represents a dioxolanyl, dioxanyl, pyrazolidinyl, benzodioxolanyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, furanyl, thienyl, pyrrolyl, pyridinyl, pyrrolidinyl or benzooxazolyl group which is unsubstituted or substituted by one or more fluorine atoms, chlorine atoms, bromine atoms, C^ alkyl groups, C x . 4 alkoxy groups and/or oxo groups. 8. A compound according to any one of claims 1 to 7 wherein R 1 represents a hydrogen, fluorine, chlorine or bromine atom or a methyl, methoxy or methylamino group. 9. A compound of formula (I) according to claim 1 which is : 2-{2-[4-(l-[l,3] dioxolan-2 -ylmethyl-IH-indol-3-yl) -piperidin-1- yl] -ethoxy} -benzoic acid; 2- (2- {4- [1- (tetrahydro-pyran-2-ylmethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- {2- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) -piperidin-1-yl] - ethoxy} -benzoic acid; 2-(2-{4-[l- (3 -pyrrol-1-yl-propyl) -IH-indol-3-yl] -piperidin-1- yl} -ethoxy) -benzoic acid; 2- (2- {4- [1- (3 -thiophen-2 -yl-propyl) -IH-indol-3-yl] -piperidin-1- yl} -ethoxy) -benzoic acid; 2- [2- (4-{l- [3- (l-methyl-lH-imidazol-2-ylsulfanyl) -propyl] -1H- indol-3-yl} -piperidin-1-yl) -ethoxy] -benzoic acid; 2- [2- (4-{l- [2- (2,5,5-trimethyl- [1, 3] dioxan-2 -yl) -ethyl] -1H- indol-3-yl} -piperidin-1-yl) -ethoxy] -benzoic acid; 2- {2- [4- (1-thiophen-2-ylmethyl-IH-indol-3-yl) -piperidin-1-yl] - ethoxy} -benzoic acid; 2- {2- [4- (1-furan-2 -ylmethyl-IH-indol-3-yl) -piperidin-1-yl] - ethoxy} -benzoic acid; 2- (2- {4- [1- (2-oxo-2-pyrrolidin-l-yl-ethyl) -IH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- {2- [4- (l-thiophen-3-ylmethyl-lH-indol-3-yl) -piperidin-1-yl] - ethoxy} -benzoic acid; 2- (2- {4- [1- (2-thiophen-2-yl-ethyl) -IH-indol-3-yl] -piperidin-1- yl} -ethoxy) -benzoic acid; 2- (2- {4- [1- (2 -thiophen-3 -yl-ethyl) -lH-indol-3-yl] -piperidin-1- yl} -ethoxy) -benzoic acid; 2- [2- (4- {l- [3- (tetrahydro-furan-2-yl) -propyl] -IH-indol-3-yl} - piperidin-1-yl) -ethoxy] -benzoic acid; 2- (2-{4- [1- (4- [1, 3] dioxolan-2-yl-butyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- [2- (4-{l- [3- (benzo [1, 3] dioxol-5-yloxy) propyl] -lH-indol-3- yl}piperidin-l-yl) ethoxy] benzoic acid; 2-[2-(4-{l-[3-(l, 3-dioxo-l,3-dihydro-isoindol-2-yl) -propyl] -1H- indol-3-yl} -piperidin-1-yl) -ethoxy] -benzoic acid; 2-{2- [4- (1-benzo [1 , 3] dioxol-5-ylmethyl-IH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid; 2- (2- (4- [1- (5-chloro-thiophen-2-ylmethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- [2- (4-{l- [4- (5-methyl-2-oxo-benzooxazol-3-yl) -butyl] -1H- indol-3-yl} -piperidin-1-yl) -ethoxy] -benzoic acid; 2- (2-{4- [1- (3- [1,3] dioxolan-2-yl-propyl) -IH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- {2- [4- (6-fluoro-1-furan-2-ylmethyl-IH-indol-3-yl) -piperidin- 1-yl] -ethoxy} -benzoic acid; 2- (2-{4- [1- (2- [1, 3] dioxolan-2-yl-ethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- (2-{4- [1- (2- [1,3] dioxolan-2-yl-ethyl) -6-fluoro-IH-indol-3- yl] -piperidin-1-yl} -ethoxy) -benzoic acid; 3- [4- (l-thiophen-2 -ylmethyl-IH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 3- [4- (1-pyridin-3 -ylmethyl-IH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 3- {4- [1- (5-chloro-thiophen-2-ylmethyl) -IH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid; 3-{4- [1- (2- [1,3] dioxolan-2-yl-ethyl) -lH-indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid; 3-{4-[l-(3-[l,3] dioxolan-2-yl-propyl) -IH-indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid; 3- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 3-(4-{l-[3- (benzo [1, 3] dioxol-5-yloxy) -propyl] -IH-indol-3-yl} - piperidin-1-ylmethyl) -benzoic acid; 3- [4- (1- [1,3] dioxolan-2-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 3- [4- (1-pyridin-2 -ylmethyl-IH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 2-methoxy-5- [4- (l-pyridin-3-ylmethyl-lH-indol-3 -yl) -piperidin- 1-ylmethyl] -benzoic acid; 5- {4- [1- (2- [1,3] dioxolan-2-yl-ethyl) -lH-indol-3-yl] -piperidin- 1-ylmethyl} -2-methoxy-benzoic acid; 5- {4- [1- (3- [1,3] dioxolan-2-yl-propyl) -IH-indol-3-yl] -piperidin- 1-ylmethyl} -2-methoxy-benzoic acid; 2-methoxy-5- [4- (1-thiophen-2-ylmethyl-IH-indol-3-yl) -piperidin- 1-ylmethyl] -benzoic acid; 2-methoxy-5- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) -piperidin- 1-ylmethyl] -benzoic acid; 4-bromo-3- [4- (1- [1, 3] dioxolan-2-ylmethyl-IH-indol-3-yl) - piperidin-1-ylmethyl] -benzoic acid; 4-bromo-3- [4- (1-pyridin-3 -ylmethyl-IH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 4-bromo-3-{4- [1- (2- [1 , 3] dioxolan-2-yl-ethyl) -IH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid; 4-bromo-3-{4-.[l- (3- [1, 3] dioxolan-2-yl-propyl) -lH-indol-3-yl] - piperidin-1-ylmethyl } -benzoic acid; 4-bromo-3- [4- (l-thiophen-2-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 2- {4- [5-methoxy-l- (2-thiophen-3-yl-ethyl) -IH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid; 3- (4-{l- [3- (benzo [1,3] dioxol-5-yloxy) -propyl] -IH-indol-3-yl} - piperidin-1-ylmethyl) -4-bromo-benzoic acid; 2-fluoro-5- [4- (1-pyridin-3-ylmethyl-IH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 5- {4- [1- (2- [1, 3] dioxolan-2-yl-ethyl) -IH-indol-3-yl] -piperidin- 1-ylmethyl} -2-fluoro-benzoic acid; 5- {4- [1- (3- [1,3] dioxolan-2-yl-propyl) -IH-indol-3-yl] -piperidin- 1-ylmethyl } -2-fluoro-benzoic acid; 2-fluoro-5- [4- (l-pyridin-4-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 5- (4- {l- [3- (benzo [1 , 3] dioxol-5-yloxy) -propyl] -IH-indol-3-yl} - piperidin-1-ylmethyl) -2-fluoro-benzoic acid; 5- [4- (1- [1, 3] dioxolan-2-ylmethyl-IH-indol-3-yl) -piperidin-1- ylmethyl] -2-fluoro-benzoic acid; 2-fluoro-5- [4- (1-pyridin-2-ylmethyl-IH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 2- (2- {4- [1- (tetrahydro-furan-3 -ylmethyl) -IH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- (2- (4- [1- (2-morpholin-4-yl-ethyl) -IH-indol-3-yl] -piperidin-1- yl} -ethoxy) -benzoic acid; 2- (2- {4- [1- (3 -methyl-oxetan-3-ylmethyl) -lH-indol-3-yl] - piperidin-l yl} -ethoxy) -benzoic acid; 2- {2- [4- (l-furan-3-ylmethyl-lH-indol-3-yl) -piperidin-1-yl] - ethoxy} -benzoic acid; 2-(2-{4-[l- (2-pyridin-2-yl-ethyl) -IH-indol-3-yl] -piperidin-1- yl} -ethoxy) -benzoic acid; 3- {4- [1- (tetrahydro-furan-3-ylmethyl) -IH-indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid; 3- {4- [1- (3-methyl-oxet n-3-ylmethyl) -IH-indol-3-yl] -piperidin- 1-ylmethyl} -benzoic acid; 3- {4- [1- (2-thiophen-3-yl-ethyl) -IH-indol-3-yl] -piperidin-1- ylmethyl} -benzoic acid; 3- [4- (l-furan-3 -ylmethyl-lH-indol-3-yl) -piperidin-1-ylmethyl] - benzoic acid; 2- [4- (l-pyridin-3-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -nicotinic acid; 2- {4- [1- (2-morpholin-4-yl-ethyl) -lH-indol-3-yl] -piperidin-1- ylmethyl} -nicotinic acid; 2- [4- (l-thiophen-2-ylmethyl-lH-indol-3-yl) -piperidin-1- yl ethyl] -nicotinic acid; 3-{4- [1- (5-chloro-thiophen-2-ylmethyl) -6-fluoro-IH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid; 3- {4- [6-fluoro-l- (2 -thiophen-3 -yl-ethyl) -IH-indol-3-yl] - piperidin-1-ylmethyl } -benzoic acid; 3-{4- [6-fluoro-l- (2 -thiophen-2-yl-ethyl) -IH-indol-3-yl] - piperidin-1-ylmethyl} -benzoic acid; 2-methoxy-5-{4- [1- (2-thiophen-2-yl-ethyl) -IH-indol-3-yl] - piperidin-l-ylmethyl} -benzoic acid; 5-{4- [6-fluoro-l- (2 -thiophen-2-yl-ethyl) -lH-indol-3 -yl] - piperidin-l-ylmethyl} -2-methoxy-benzoic acid; 5- {4- [6-fluoro-l- (2-morpholin-4-yl-ethyl) -lH-indol-3-yl] - piperidin-l-ylmethyl} -2-methoxy-benzoic acid; 5- {4- [1- (2- [1,4] dioxan-2-yl-ethyl) -IH-indol-3-yl] -piperidin-l- ylmethyl} -2-methoxy-benzoic acid; 3-{4- [1- (2- [1,4] dioxan-2-yl-ethyl) -IH-indol-3-yl] -piperidin-l- ylmethyl} -benzoic acid; 2-methoxy-5- [4- (l-thiophen-2-ylmethyl-IH-indol-3-yl) -piperidin- l-ylmethyl] -benzoic acid; 4-bromo-3- [4- (1-pyridin-4-ylmethyl-IH-indol-3-yl) -piperidin-l- ylmethyl] -benzoic acid; 2-methoxy-5-{4- [1- (2-thiophen-3-yl-ethyl) -IH-indol-3-yl] - piperidin-l-ylmethyl} -benzoic acid; 3- {4- [1- (2 -morpholin-4-yl-ethyl) -lH-indol-3-yl] -piperidin-l- ylmethyl} -benzoic acid; 2- [2- (4-{l- [2- (benzo [1,3] dioxol-5-yloxy) -ethyl] -lH-indol-3-yl} - piperidin-1-yl) -ethoxy] -benzoic acid; 5-{4- [6-fluoro-l- (2-thiophen-3 -yl-ethyl) -lH-indol-3 -yl] - piperidin-l-ylmethyl} -2-methoxy-benzoic acid; 5- {4- [1- (5-chloro-thiophen-2-ylmethyl) -6-fluoro-lH-indol-3-yl] - piperidin-l-ylmethyl} -2-methoxy-benzoic acid; 5- [4- (6-fluoro-l-furan-3-ylmethyl-lH-indol-3-yl) -piperidin-1- ylmethyl] -2-methoxy-benzoic acid; 3- {4- [1- (2-pyridin-2-yl-ethyl) -IH-indol-3-yl] -piperidin-l- ylmethyl} -benzoic acid; 5- [4- (6-fluoro-l-thiophen-2-ylmethyl-lH-indol-3-yl) -piperidin- l-ylmethyl] -2-methoxy-benzoic acid; 3- [4- (l-furan-2-ylmethyl-lH-indol-3-yl) -piperidin-l-ylmethyl] - benzoic acid; 2- (2- {4- [1- (2- [1,4] dioxan-2 -yl-ethyl) -IH-indol-3-yl] -piperidin- 1-yl} -ethoxy) -benzoic acid; 5- [4- (l-furan-2-ylmethyl-IH-indol-3-yl) -piperidin-l-ylmethyl] - 2-methoxy-benzoic acid; 5- [4- (l-furan-3 -ylmethyl-IH-indol-3-yl) -piperidin-l-ylmethyl] - 2-methoxy-benzoic acid; 3- {4- [5-methoxy-l- (2-thiophen-3 -yl-ethyl) -IH-indol-3-yl] - piperidin-l-ylmethyl} -benzoic acid; 2- (2- {4- [5-methoxy-l- (2-thiophen-3-yl-ethyl) -IH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- {2- [4- (5-methoxy-l-thiophen-2-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid; 3- [4- (5-methoxy-1-thiophen-2-ylmethyl-IH-indol-3-yl) -piperidin- l-ylmethyl] -benzoic acid; 2-methoxy-5-{4- [5-methoxy-l- (2-thiophen-3-yl-ethyl) -IH-indol-3- yl] -piperidin-l-ylmethyl} -benzoic acid; 2- {2- [4- (l-furan-3-ylmethyl-5-methoxy-IH-indol-3-yl) -piperidin- 1-yl] -ethoxy} -benzoic acid; 3- [4- (l-furan-3 -ylmethyl-5-methoxy-IH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 2- [4- (l-furan-2-ylmethyl-IH-indol-3-yl) -piperidin-l-ylmethyl] - benzoic acid; 2- [4- (6-fluoro-l-furan-2-ylmethyl-IH-indol-3-yl) -piperidin-l- ylmethyl] -benzoic acid; 3- [4- (6-fluoro-l-furan-2-ylmethyl-lH-indol-3-yl) -piperidin-l- ylmethyl] -benzoic acid; 5- [4- (6-fluoro-1-furan-2-ylmethyl-IH-indol-3-yl) -piperidin-l- ylmethyl] -2-methoxy-benzoic acid; 4-methoxy-2- [4- (5-methoxy-1-thiophen-2-ylmethyl-IH-indol-3-yl) - piperidin-l-ylmethyl] -benzoic acid; 2- [4- (5-methoxy-1-thiophen-2 -ylmethyl-IH-indol-3-yl) -piperidin- l-ylmethyl] -benzoic acid; 2-methoxy-5- [4- (5-methoxy-1-thiophen-2-ylmethyl-IH-indol-3-yl) - piperidin-l-ylmethyl] -benzoic acid; 2- [4- (1-furan-2-ylmethyl-5-methoxy-IH-indol-3-yl) -piperidin-l- ylmethyl] -4-methoxy-benzoic acid; 3- [4- (l-furan-2-ylmethyl-5-methoxy-lH-indol-3-yl) -piperidin-l- ylmethyl] -benzoic acid; 2- [4- (l-furan-2 -ylmethyl-5-methoxy-lH-indol-3-yl) -piperidin-1- ylmethyl] -benzoic acid; 5- [4- (l-furan-2-ylmethyl-5-methoxy-lH-indol-3-yl) -piperidin-l- ylmethyl] -2-methoxy-benzoic acid; 2- {2- [4- (l-furan-2-ylmethyl-5-methoxy-lH-indol-3-yl) -piperidin- 1-yl] -ethoxy} -benzoic acid; 4-methoxy-2- {4- [5-methoxy-l- (2-thiophen-3 -yl-ethyl) -lH-indol-3- yl] -piperidin-l-ylmethyl} -benzoic acid; 2- {2- [4- (6-fluoro-l-thiophen-2-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid; 5- [4- (6-fluoro-l-thiophen-3-ylmethyl-lH-indol-3-yl) -piperidin- l-ylmethyl] -2-methoxy-benzoic acid; 2- {2- [4- (6-fluoro-l-thiophen-3-ylmethyl-lH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid; 2- (2-{4- [6-fluoro-l- (2-thiophen-3 -yl-ethyl) -lH-indol-3-yl] - piperidin-1-yl} -ethoxy) -benzoic acid; 2- (2- {4- [1- (5-chloro-thiophen-2-ylmethyl) -6-fluoro-lH-indol-3- yl] -piperidin-1-yl} -ethoxy) -benzoic acid; 2- {2- [4- (6-fluoro-l-furan-3-ylmethyl-IH-indol-3-yl) -piperidin- 1-yl] -ethoxy} -benzoic acid; 2- {2- [4- (5-methoxy-1-thiophen-3-ylmethyl-IH-indol-3-yl) - piperidin-1-yl] -ethoxy} -benzoic acid; 3- [4- (5-methoxy-1-thiophen-3-ylmethyl-IH-indol-3-yl) -piperidin- l-ylmethyl] -benzoic acid; 2- (2- {4- [1- (5-chloro-thiophen-2 -ylmethyl) -5-methoxy-IH-indol-3- yl] -piperidin-1-yl} -ethoxy) -benzoic acid; 3- {4- [1- (5-chloro-thiophen-2 -ylmethyl) -5-methoxy-IH-indol-3- yl] -piperidin-l-ylmethyl} -benzoic acid; 2-methoxy-5- [4- (l-thiophen-3-ylmethyl-lH-indol-3-yl) -piperidin- l-ylmethyl] -benzoic acid; 3- [4- (1-thiophen-3 -ylmethyl-IH-indol-3-yl) -piperidin-l- ylmethyl] -benzoic acid; 5- {4- [1- (5-chloro-thiophen-2-ylmethyl) -5-methoxy-IH-indol-3- yl] -piperidin-l-ylmethyl} -2-methoxy-benzoic acid; 3- {4- [5-methoxy-l- (2-thiophen-2 -yl-ethyl) -IH-indol-3-yl] - piperidin-1-ylmethyl } -benzoic acid; 2-methoxy-5-{4- [5-methoxy-l- (2-thiophen-2-yl-ethyl) -lH-indol-3- yl] -piperidin-l-ylmethyl} -benzoic acid; or a pharmaceutically acceptable salt thereof. 10. A process for producing a compound of formula (I) as defined in any one of claims 1 to 9, which process comprises for compounds of formula (I) wherein R 2 is a carboxyl group, the hydrolysis of a compound of formula (VI) wherein A 1 , A 2 , W 1 , W 2 and R 1 are as defined in claim 1 and R 3 is a -COOR 4 group wherein R 4 represents a C x -C 4 alkyl group. 11. A pharmaceutical composition comprising a compound according to any one of claims 1 to 9 and a pharmaceutically acceptable diluent or carrier. 12. A compound according to any one of claims 1 to 9 or a composition according to claim 11 for use in a method of treatment of the human or animal body. 13. Use of a compound as defined in any one of claims 1 to 9 in the manufacture of a medicament for the treatment of an allergic disorder or disease. 14. Use according to claim 13 wherein the medicament is for the treatment of bronchial asthma, rhinitis, conjunctivitis, dermatitis or urticaria. 15. A method of treating an allergic disorder or disease which comprises administering to a human or animal patient in need of such treatment an effective amount of a compound according to any one of claims 1 to 9 or a composition according to claim 11.

Inventors: FONQUERNA POU SILVIA, PAGES SANTACANA LLUIS, PUIG DURAN CARLES, SOCA PUEYO LIDIA, FONQUERNA POU, SILVIA, PAGES SANTACANA, LLUIS, PUIG DURAN, CARLES, SOCA PUEYO, LIDIA
Applicants: ALMIRALL PRODESFARMA SA, FONQUERNA POU SILVIA, PAGES SANTACANA LLUIS, PUIG DURAN CARLES, SOCA PUEYO LIDIA, ALMIRALL PRODESFARMA S.A., FONQUERNA POU, SILVIA, PAGES SANTACANA, LLUIS, PUIG DURAN, CARLES, SOCA PUEYO, LIDIA
Application year: 2001
Main classification: C07D405
IPC codes: A61K31, A61P11, A61P17, A61P27, A61P37, A61P43, C07D401, C07D405, C07D409, C07D413