PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS

Abstract: A compound of Formula (I) wherein R<1>, R<2> and R<3> are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3.

Description: PYRROIiO (2 , 3-D) PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS Background of the Invention The present invention relates to pyrrolo[2,3-d]pyrimidine compounds which are inhibitors of protein kinases, such as the enzyme Janus Kinase 3 (hereinafter also referred to as JAK3) and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplantation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other indications where immunosuppression would be desirable. This invention also relates to a method of using such compounds in the treatment of the above indications in mammals, especially humans, and the pharmaceutical compositions useful therefor. JAK3 is a member of the Janus family of protein kinases. Although the other members of this family are expressed by essentially all tissues, JAK3 expression is limited to hematopoetic cells. This is consistent with its essential role in signaling through the receptors for IL-2, IL-4, IL-7, IL-9 and IL-15 by non-covalent association of JAK3 with the gamma chain common to these multichain receptors. XSCID patient populations have been identified with severely reduced levels of JAK3 protein or with genetic defects to the common gamma chain, suggesting that immunosuppression should result from blocking signaling through the JAK3 pathway. Animal studies have suggested that JAK3 not only plays a critical role in B and T lymphocyte maturation, but that JAK3 is constitutively required to maintain T cell function. Modulation of immune activity through this novel mechanism can prove useful in the treatment of T cell proliferative disorders such as transplant rejection and autoimmune diseases. Summary of the Invention The present invention relates to a compound of the formula or the pharmaceutically acceptable salt thereof; wherein R 1 is a group of the formula wherein y is 0, 1 or 2; R 4 is selected from the group consisting of hydrogen, (d-C 6 )alkyl, (C r C 6 )alkylsulfonyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C C 4 )alkoxy, (CrC 6 )acyloxy, (C.|-C 6 )alkylannino, ((C C 6 )alkyl) 2 amino, cyano, nitro, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl or (CτC 6 )acylamino; or R 4 is (C 3 -C 10 )cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C C 6 )acyloxy, (d-CeJacylamino, (CτC 6 )alkylamino, ((C r C 6 )alkyl) 2 amino, cyano, cyano(C C 6 )alkyl, trifluoromethyl(C C 6 )alkyl, nitro, nitroCC CeJalkyl or (C C 6 )acylamino; R 5 is (C 2 -C 9 )heterocycloalkyl wherein the heterocycloalkyl groups must be substituted by one to five groups consisting of carboxy, cyano, amino, deuterium, hydroxy, (C.|-C 6 )alkyl, (C C 6 )alkoxy, halo, (C 1 -C 6 )acyl, (C C 6 )alkylamino, amino(C C 6 )alkyl, (C C 6 )alkoxy-CO-NH, (C C 6 )alkylamino-CO-, (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, (CrC 6 )alkylamino, amino(C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, (d- C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )acyloxy(C 1 -C 6 )alkyl, nitro, cyano(CrC 6 )alkyl, halo(C C 6 )alkyl, nitro(C 1 -C 6 )alkyl, trifluoromethyl, trifluoromethyl(C 1 -C 6 )alkyl, (C C 6 )acylamino, (C 1 -C 6 )acylamino(C 1 -C 6 )alkyl, amino(C 1 -C 6 )acyl, amino(C 1 -C 6 )acyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylamino(C 1 -C 6 )acyl, ((C-,- C 6 )alkyl) 2 amino(C 1 -C 6 )acyl, R 15 R 16 N-CO-O-, R^R^N-CO-CC-rCeJalkyl, (C 1 -C 6 )alkyl- S(O) m , R 15 R 16 NS(O) m , R 15 R 16 NS(O) m (C C 6 )alkyl, R 15 S(O) m R 16 N, R^SCO^R^NCd- C 6 )alkyl wherein m is 0, 1 or 2 and R 15 and R 16 are each independently selected from hydrogen or (C C 6 )alkyl; and a group of the formula wherein a is 0, 1 , 2, 3 or 4; b, c, e, f and g are each independently 0 or 1 ; d is O, 1, 2, or 3; X is S(O) n wherein n is 0, 1 or 2; oxygen, carbonyl or -C(=N-cyano)-; Y is S(O) n wherein n is 0, 1 or 2; or carbonyl; and Z is carbonyl, C(O)O-, C(O)NR- wherein R is hydrogen or (C C 6 )alkyl; or Z is S(O) n wherein n is 0, 1 or 2; R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently selected from the group consisting of hydrogen or (d-CβJalkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C-ι-C 6 )acyloxy, (C 1 -C 6 )acylamino, (C C 6 )alkylamino, ((d- C 6 )alkyl) 2 amino, cyano, cyano(C C 6 )alkyl, trifluoromethyl(d-C 6 )alkyl, nitro, nitro(Cι-C 6 )alkyl or (d-C δ Jacylamino; R is (C 6 -C 0 )aryl, (C 2 -C 8 )heteroaryl, (C 3 -C 10 )cycloalkyl or (C 2 - C 9 )heterocycloalkyl, wherein the aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups are optionally substituted by one to four groups consisting of hydrogen, deuterium, amino, halo, oxo, hydroxy, nitro, carboxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, trifluoromethyl, trifluoromethoxy, (C C 6 )alkyl, (C C 6 )alkoxy, (C 3 -C 10 )cycloalkyl, (d- C 6 )alkyl-CO-NH-, (C 1 -C 6 )alkoxy-CO-NH-, (d-d alkyl-CO-NhKd-C^alkyl, (C C 6 )alkoxy-CO-NH-(C r C 6 )alkyl, (C 1 -C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkoxy, carboxy, carboxy(C 1 -C 6 )alkyl, carboxy(C -C 6 )alkoxy, benzyloxycarbonyl(C C 6 )alkoxy, (d- CeJalkoxycarbony C CeJalkoxy, (C 6 -C 10 )aryl, amino, amino(C C 6 )alkyl, (C C 6 )alkoxycarbonylamino, (C 6 -C 10 )aryl(CrC 6 )alkoxycarbonylamino, (d-C 6 )alkylamino, ((CrC 6 )alkyl) 2 amino, (d-C^alkylaminoCd-CeJalkyl, ((C 1 -C 6 )alkyl) 2 amino(CrC 6 )alkyl, hydroxy, (C 1 -C 6 )alkoxy, carboxy, carboxy(C C 6 )alkyl, (C r C 6 )alkoxycarbonyl, (d- C 6 )alkoxycarbonyl(d-C 6 )alkyl, (C C 6 )alkoxy-CO-NH-, (C C 6 )alkyl-CO-NH-, cyano, (C 5 -C 9 )heterocycloalkyl, amino-CO-NH-, (C C 6 )alkylamino-CO-NH-, ((d- C 6 )alkyl) 2 amino-CO-NH-, (C 6 -C 0 )arylamino-CO-NH-, (C 5 -C 9 )heteroarylamino-CO- NH-, (d-C 6 )alkylamino-CO-NH-(d-C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino-CO-NH-(C 1 - C 6 )alkyl, (C 6 -C 10 )arylamino-CO-NH-(C 1 -C 6 )alkyl, (C 5 -C 9 )heteroarylamino-CO-NH-(C C 6 )alkyl, (C 1 -C 6 )alkylcyano, (CrC 6 )alkylcarboxy(Cι-C 6 )alkoxy, (d-C 6 )alkylcarboxy, sulfonylamino, aminosulfonyl, sulfonylamino(C C 6 )alkyl, sulfonylaminocarboxy(C C 6 )alkyl, (d-CeJalkylsulfonyl, (C C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylsulfonylamino(C 1 - C 6 )alkyl, (C 6 -C 10 )arylsulfonyl, (C 6 -C 10 )arylsulfonylamino, (C 6 -C 10 )arylsulfonylamino(C 1 - C 6 )alkyl, (C C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylsulfonylamino(C 1 -C 6 )alkyl, (C 3 - C 10 )cycloalkyl, (C 3 -C 10 )cycloalkoxy, (CrC 6 )alkylamino, ((C C 6 )alkyl) 2 amino, (C 6 - C 10 )arylamino, (C C 6 )alkylthio, (C 6 -C 10 )arylthio, (C CeJalkylsulfinyl, (C 6 - C 10 )arylsulfinyl, (C C 6 )alkylsulfonyl, (C 6 -C 10 )arylsulfonyl, (CrC 6 )acyl, (C C 6 )alkoxy- CO-NH-, (d-C 6 )alkyamino-CO-, (C 5 -C 9 )heteroaryl, (C 2 -C 9 )heterocycloalkyl or (C 6 - C-io)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups which are optionally substituted on R 12 may be further substituted by one to three groups consisting of halo, (C C 6 )alkyl, (d-C 6 )alkyl-CO-NH-, (d-C 6 )alkoxy-CO-NH-, (C C 6 )alkyl-CO-NH- (d-C-e alkyl, (C 1 -C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkyl, (Cι-C 6 )alkoxy-CO-NH-(d-C 6 )alkoxy, carboxy,* carboxy(C C 6 )alkyl, carboxy(d-C 6 )alkoxy, benzyloxycarbonyl(C 1 -C 6 )alkoxy, (Cι-C 6 )alkoxycarbonyl(d-C 6 )alkoxy, (C 6 -Cι 0 )aryl, amino, amino(C C 6 )alkyl, (C C 6 )alkoxycarbonylamino, (Ce-dc ary d-Q alkoxycarbonylamino, (C C 6 )alkylamino, ((C C 6 )alkyl) 2 amino, (C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino(C 1 -C 6 )alkyl, hydroxy, (C-|-C 6 )alkoxy, carboxy, carboxy(C C 6 )alkyl, (d-C^alkoxycarbonyl, (d- C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, (C C 6 )alkoxy-CO-NH-, (C C 6 )alkyl-CO-NH-, cyano, (C 5 -C 9 )heterocycloalkyl, amino-CO-NH-, (C C 6 )alkylamino-CO-NH-, ((C C 6 )alkyl) 2 amino-CO-NH-, (C 6 -C 10 )arylamino-CO-NH-, (C 5 -C 9 )heteroarylamino-CO- NH-, (d-C 6 )alkylamino-CO-NH-(d-C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino-CO-NH-(C 1 - C 6 )alkyl, (Ce-CioJarylamino-CO-NH-Cd-CeJalkyl, (C 5 -C 9 )heteroarylamino-CO-NH-(d- C 6 )alkyl, (C C 6 )alkylsulfonyl, (d-C 6 )alkylsulfonylamino, (C C 6 )alkylsulfonylamino(C 1 -C 6 )alkyl, (C 6 -C 10 )arylsulfonyl, (C 6 -C 10 )arylsulfonylamino, (C 6 - C 10 )arylsulfonylamino(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonylamino, (d- C6)alkylsulfonylamino(CrC 6 )alkyl, (C 5 -C 9 )heteroaryl and (C 2 -C 9 )heterocycloalkyl; R 2 and R 3 are each independently selected from the group consisting of hydrogen, deuterium, amino, halo, hydroxy, nitro, carboxy, (C 2 -C 6 )alkenyl, (C 2 - C 6 )alkynyl, trifluoromethyl, trifluoromethoxy, (C C 6 )alkyl, (C C 6 )alkoxy, (C 3 - C 10 )cycloalkyl wherein the alkyl, alkoxy or cycloalkyl groups are optionally substittued by one to three groups selected from halo, hydroxy, carboxy, amino (C C 6 )alkylthio, (d-C 6 )alkylamino, ((C C 6 )alkyl) 2 amino, (C 5 -C 9 )heteroaryl, (C 2 -C 9 )heterocycloalkyl, (C 3 -C 9 )cycloalkyl or (C 6 -C 10 )aryl; or R 2 and R 3 are each independently (C 3 - C 0 )cycloalkyl, (C 3 -C 10 )cycloalkoxy, (CrC 6 )alkylamino, ((CrC 6 )alkyl) 2 amino, (C 6 - C 10 )arylamino, (C 1 -C 6 )alkylthio, (C 6 -C 10 )arylthio, (C 1 -C 6 )alkylsulfinyl, (C 6 - C 10 )arylsulfinyl, (C C 6 )alkylsulfonyl, (C 6 -C 10 )arylsulfonyl, (Cι-C 6 )acyl, (d-C 6 )alkoxy- CO-NH-, (d-C 6 )alkyamino-CO-, (C 5 -C 9 )heteroaryl, (C 2 -C 9 )heterocycloalkyl or (C 6 - C 10 )aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C.-C 6 )alkyl, (C.-C 6 )alkyl-CO-NH-, (C C 6 )alkoxy- CO-NH-, (C 1 -C 6 )alkyl-CO-NH-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkyl, (d- C 6 )alkoxy-CO-NH-(C C 6 )alkoxy, carboxy, carboxy(C 1 -C 6 )alkyl, carboxy(Cι-C 6 )alkoxy, benzyloxycarbonyl(Cι-C 6 )alkoxy, (C d alkoxycarbony d-CeJalkoxy, (C 6 -C 10 )aryl, amino, amino(C 1 -C 6 )alkyl, (CrC 6 )alkoxycarbonylamino, (C 6 -C 10 )aryl(C 1 - C 6 )alkoxycarbonylamino, (CrC 6 )alkylamino, ((C 1 -C 6 )alkyl) 2 amino, (C C 6 )alkylamino(C 1 -C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino(C 1 -C 6 )alkyl, hydroxy, (C C 6 )alkoxy, carboxy, carboxy(C C 6 )alkyl, (C C 6 )alkoxycarbonyl, (C 1 -C 6 )alkoxycarbonyl(C 1 - C 6 )alkyl, (d-C 6 )alkoxy-CO-NH-, (C C 6 )alkyl-CO-NH-, cyano, (C 5 -C 9 )heterocycloalkyl, amino-CO-NH-, (C 1 -C 6 )alkylamino-CO-NH-, ((d-C 6 )alkyl) 2 amino-CO-NH-, (C 6 - C 10 )arylamino-CO-NH-, (C 5 -C 9 )heteroarylamino-CO-NH-, (C C 6 )alkylamino-CO-NH- (d-C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino-CO-NH-(C 1 -C 6 )alkyl, (C 6 -C 10 )arylamino-CO-NH-(d- C 6 )alkyl, (C 5 -C 9 )heteroarylamino-CO-NH-(d-C 6 )alkyl, (C C 6 )alkylsulfonyl, (C C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylsulfonylamino(C 1 -C 6 )alkyl, (C 6 -C 10 )arylsulfonyl, (C 6 - C 10 )arylsulfonylamino, (C 6 -C 10 )arylsulfonylamino(C 1 -C 6 )alkyl, (d- C 6 )alkylsulfonylamino, (Cι-C 6 )alkylsulfonylamino(C C 6 )alkyl, (C 5 -C 9 )heteroaryl or (C 2 - C 9 )heterocycloalkyl; with the proviso that R 5 must be substituted by the group of formula II. The present invention also relates to the pharmaceutically acceptable acid addition salts of compounds of the formula I. The acids which are used to prepare the pharmaceutically acceptable acid addition salts of the aforementioned base compounds of this invention are those which form non-toxic acid addition salts, i.e., salts containing pharmacologically acceptable anions, such as the hydrochloride, hydrobromide, hydroiodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, acetate, lactate, citrate, acid citrate, tartrate, bitartrate, succinate, maleate, fumarate, gluconate, saccharate, benzoate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate and pamoate [i.e., 1 ,1 '-methylene-bis-(2-hydroxy-3- naphthoate)]salts. The invention also relates to base addition salts of formula I. The chemical bases that may be used as reagents to prepare pharmaceutically acceptable base salts of those compounds of formula I that are acidic in nature are those that form non-toxic base salts with such compounds. Such non-toxic base salts include, but are not limited to those derived from such pharmacologically acceptable cations such as alkali metal cations (e.g., potassium and sodium) and alkaline earth metal cations (e.g., calcium and magnesium), ammonium or water-soluble amine addition salts such as N-methylglucamine-(meglumine), and the lower alkanolammonium and other base salts of pharmaceutically acceptable organic amines. The term "Oxone®" is a name of a monopersulfate compound used in this invention, having the formula 2KHSO 5 KHSO 4 K 2 SO , and sold by Aldrich Chemical Company, P.O. Box 2060, Milwaukee, Wl 53201 , USA. The term "alkyl", as used herein, unless otherwise indicated, includes saturated monovalent hydrocarbon radicals having straight or branched moieties or combinations thereof. The term "alkoxy", as used herein, includes O-alkyl groups wherein "alkyl" is defined above. The term "halo", as used herein, unless otherwise indicated, includes fluoro, chloro, bromo or iodo. The compounds of this invention may contain double bonds. When such bonds are present, the compounds of the invention exist as cis and trans configurations and as mixtures thereof. Unless otherwise indicated, the alkyl and alkenyl groups referred to herein, as well as the alkyl moieties of other groups referred to herein (e.g., alkoxy), may be linear or branched, and they may also be cyclic (e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl) or be linear or branched and contain cyclic moieties. Unless otherwise indicated, halogen includes fluorine, chlorine, bromine, and iodine. (C 2 -C 9 )Heterocycloalkyl when used herein refers to pyrrolidinyl, tetrahydrofuranyl, dihydrofuranyl, tetrahydropyranyl, pyranyl, thiopyranyl, aziridinyl, oxiranyl, methylenedioxyl, chromenyl, isoxazolidinyl, 1 ,3-oxazolidin-3-yl, isothiazolidinyl, 1 ,3-thiazolidin-3-yl, 1 ,2-pyrazolidin-2-yl, 1,3-pyrazolidin-1-yl, piperidinyl, thiomorpholinyl, 1 ,2-tetrahydrothiazin-2-yl, 1 ,3-tetrahydrothiazin-3-yl, tetrahydrothiadiazinyl, morpholinyl, 1 ,2-tetrahydrodiazin-2-yl, 1 ,3-tetrahydrodiazin-1- yl, tetrahydroazepinyl, piperazinyl, chromanyl, etc. One of ordinary skill in the art will understand that the connection of said (C 2 -C 9 )heterocycloalkyl rings is through a carbon or a sp 3 hybridized nitrogen heteroatom. (C 2 -C 9 )Heteroaryl when used herein refers to furyl, thienyl, thiazolyl, pyrazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyrrolyl, triazolyl, tetrazolyl, imidazolyl, 1 ,3,5- oxadiazolyl, 1 ,2,4-oxadiazolyl, 1 ,2,3-oxadiazolyl, 1 ,3,5-thiadiazolyl, 1 ,2,3-thiadiazolyl, 1 ,2,4-thiadiazolyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, 1 ,2,4-triazinyl, 1 ,2,3- triazinyl, 1 ,3,5-triazinyl, pyrazolo[3,4-b]pyridinyl, cinnolinyl, pteridinyl, purinyl, 6,7- dihydro-5H-[1]pyrindinyl, benzo[b]thiophenyl, 5, 6, 7, 8-tetrahydro-quinolin-3-yl, benzoxazolyl, benzothiazolyl, benzisothiazolyl, benzisoxazolyl, benzimidazolyl, thianaphthenyl, isothianaphthenyl, benzofuranyl, isobenzofuranyl, isoindolyl, indolyl, indolizinyl, indazolyl, isoquinolyl, quinolyl, phthalazinyl, quinoxalinyl, quinazolinyl, benzoxazinyl; etc. One of ordinary skill in the art will understand that the connection of said (C 2 -C 9 )heterocycloalkyl rings is through a carbon atom or a sp 3 hybridized nitrogen heteroatom. (C 6 -C 10 )aryl when used herein refers to phenyl or naphthyl. Compounds of formula (I) may be administered in a pharmaceutically acceptable form either alone or in combination with one or more additional agents which modulate a mammalian immune system or with antiinflammatory agents. These agents may include but are not limited to cyclosporin A (e.g. Sandimmune ® or Neoral ® , rapamycin, FK-506 (tacrolimus), leflunomide, deoxyspergualin, mycophenolate (e.g. Cellcept ® ), azathiophne (e.g. Imuran ® ), daclizumab (e.g. Zenapax ® . OKT3 (e.g. Orthoclone ® ), AtGam, aspirin, acetaminophen, ibuprofen, naproxen, piroxicam, and antiinflammatory steroids (e.g. prednisolone or dexamethasone). These agents may be administered as part of the same or separate dosage forms, via the same or different routes of administration, and on the same or different administration schedules according to standard pharmaceutical practice. The compounds of this invention include all conformational isomers (e.g., cis and trans isomers. The compounds of the present invention have asymmetric centers and therefore exist in different enantiomeric and diastereomehc forms. This invention relates to the use of all optical isomers and stereoisomers of the compounds of the present invention, and mixtures thereof, and to all pharmaceutical compositions and methods of treatment that may employ or contain them. In this regard, the invention includes both the E and Z configurations. The compounds of formula I may also exist as tautomers. This invention relates to the use of all such tautomers and mixtures thereof. This invention also encompasses pharmaceutical compositions containing prodrugs of compounds of the formula I. This invention also encompasses methods of treating or preventing disorders that can be treated or prevented by the inhibition of protein kinases, such as the enzyme Janus Kinase 3 comprising administering prodrugs of compounds of the formula I. Compounds of formula I having free amino, amido, hydroxy or carboxylic groups can be converted into prodrugs. Prodrugs include compounds wherein an amino acid residue, or a polypeptide chain of two or more (e.g., two, three or four) amino acid residues which are covalently joined through peptide bonds to free amino, hydroxy or carboxylic acid groups of compounds of formula I. The amino acid residues include the 20 naturally occurring amino acids commonly designated by three letter symbols and also include, 4- hydroxyproline, hydroxylysine, demosine, isodemosine, 3-methylhistidine, norvlin, beta-alanine, gamma-aminobutyric acid, citrulline, homocysteine, homoserine, ornithine and methioine sulfone. Prodrugs also include compounds wherein carbonates, carbamates, amides and alkyl esters which are covalently bonded to the above substituents of formula I through the carbonyl carbon prodrug sidechain. Preferred compounds of formula I include those wherein R 5 is (C 2 - C 9 )heterocycloalkyl optionally substituted by one to three groups selected from deuterium, hydroxy, (C C 6 )alkyl, halo, (C C 6 )alkoxy and a group of formula II. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is carbonyl; c is 0; d is 0; e is 0; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1; X is carbonyl; c is 0; d is 1 ; e is 0; f is 0, and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is carbonyl; c is 1 ; d is 0; e is 0; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is -C(=N=cyano)-; c is 1 ; d is 0; e is 0; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 0; c is 0; d is 0; e is 0; f is 0; g is 1 ; and Z is -C(O)-O-. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is S(O) n ; n is 2; c is 0; d is 0; e is 0; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is S(O) n ; n is 2; c is 0; d is 2; e is 0; f is 1 ; g is 1 ; and Z is carbonyl. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is S(O) n ; n is 2; c is 0; d is 2; e is 0; f is 1 ; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is carbonyl; c is 1 ; d is 0; e is 1 ; Y is S(O) n ; n is 2; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is S(O) n ; n is 2; c is 1 ; d is 0; e is 0; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 1 ; b is 1 ; X is carbonyl; c is 1 ; d is 0; e is 0; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is S(O) n ; c is 0; d is 1 ; e is 1 ; Y is S(O) n ; n is 2; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is S(O) n ; c is 0; d is 1 ; e is 1 ; Y is S(O) n ; n is 2; f is 1 ; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is oxygen; c is 0; d is 1 ; e is 1 ; Y is S(O) n ; n is 2; f is 1 ; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is oxygen; c is 0; d is 1 ; e is 1 ; Y is S(O) n ; n is 2; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is carbonyl; c is 1 ; d is 1 ; e is 1 ; Y is S(O) n ; f is 0; and g is 0. Other preferred compounds of formula I include those wherein a is 0; b is 1 ; X is carbonyl; c is 1 ; d is 1 ; e is 1 ; Y is S(O) n ; n is 2; f is 1 ; and g is 0. Other preferred compounds of formula I include those wherein R 12 is (C 6 - C-ιo)aryl or (C 2 -C 9 )heteroaryl wherein the aryl or heteroaryl group is optionally substituted by one to four groups consisting of hydrogen, halo, hydroxy, carboxy, trifluormethyl, (C r C 6 )alkyl, (d-C 6 )alkoxy, (C C 6 )alkyl-CO-NH-, amino, amino(C C 6 )alkyl, (Cι-C 6 )alkylamino, ((C C 6 )alkyl) 2 amino, cyano, amino-CO-NH-, (d- C 6 )alkylamino-CO-NH-, ((C r C 6 )alkyl) 2 amino-CO-NH-, (C 5 -C 9 )heteroarylamino-CO- NH-, (d-C 6 )alkylsulfonyl, (d-C 6 )alkylsulfonylamino, (C 6 -C 10 )arylsulfonylamino, (d- C 6 )alkylsulfonylamino, and (d-C 6 )alkoxy-CO-NH-. Specific preferred compounds of formula I include those wherein said compound is selected from the group consisting of: 4-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1- ylmethyl}-benzenesulfonamide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-sulfamoyl-phenyl)-amide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-nitro-phenyl)-amide; -{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1- yl}-2-tetrazoI-1 -yl-ethanone; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-methylsulfamoyl-phenyl)-amide; (3-Hydroxy-pyrrolidin-1-yl)-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)-amino]-piperidin-1 -yl}-methanone; [2-({4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine- 1-carbonyl}-amino)- thiazol-4-yl]-acetic acid; Methyl-(4-methyl-5'-nitro-3,4,5,6-tetrahydro-2H-[1 ,2']bipyridinyl-3-yl)-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-amine; 5-(2-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin- 1 -yl}-2-oxo-ethyl)- thiazolidine-2,4-dione; {4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}- thiazolidin-3-yl-methanone; Methyl-[4-methyl-1-(5-nitro-thiazol-2-yl)-pipehdin-3-yl]-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-amine; [2-({4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine- 1-carbonyl}-amino)- thiazol-4-yl]-acetic acid ethyl ester; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-methanesulfonyl-phenyl)-amide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid thiazol-2-ylamide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-cyano-phenyl)-amide; {4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}- pyrrolidin-1 -yl-methanone; Furan-2-carboxylic acid (2-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)-amino]-piperidine-1-sulfonyl}-ethyl)-amide; {4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl} (tetrahydro-furan-3-yl)-methanone; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid isoxazol-3-ylamide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (6-cyano-pyridin-3-yl)-amide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-3,4,5,6- tetrahydro-2H-[1 ,2']bipyridinyl-5'-carbonitrile 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-methyl-thiazol-2-yl)-amide; 2-Cyclopropyl-1-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- amino]-piperidin-1-yl}-ethanone; Cyclopentyl-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]- piperidin-1 -yl}-Methanone; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1 - carboxylic acid (3-methyl-isoxazol-4-yl)-amide; [4-({4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine- 1-carbonyl}-amino)- phenylj-acetic acid; [1-(5-Amino-thiazol-2-yl)-4-methyl-piperidin-3-yl]-methyl-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-amine; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (3-methyl-isothiazol-5-yl)-amide; 3-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pipehdine-1- carbonyl}-cyclopentanone; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid benzyl-methyl-amide; and 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid dimethylamide. The present invention also relates to a pharmaceutical composition for (a) treating or preventing a disorder or condition selected from organ transplant rejection, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia, and other autoimmune diseases or (b) the inhibition of protein kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising an amount of a compound of formula I or a pharmaceutically acceptable salt thereof, effective in such disorders or conditions and a pharmaceutically acceptable carrier. The present invention also relates to a method for the inhibition of protein typrosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising administering to said mammal an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for treating or preventing a disorder or condition selected from organ transplant rejection, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia, and other autoimmune diseases in a mammal, including a human, comprising administering to said mammal an amount of a compound of formula I or a pharmaceutically acceptable salt thereof, effective in treating such a condition. Detailed Description of the Invention The following reaction Schemes illustrate the preparation of the compounds of the present invention. Unless otherwise indicated R 2 , R 3 , R 4 and R 5 in the reaction Schemes and the discussion that follow are defined as above. PREPARATION A PREPARATION B PREPARATION C XXVIII SCHEME 1 SCHEME 2 III SCHEME 3 ln reaction 1 of Preparation A, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XXI, wherein R is hydrogen or a protecting group such as benzenesulfonyl or benzyl, is converted to the 4-chloro-5-halopyrrolo[2,3-d]pyrimidine compound of formula XX, wherein Y is chloro, bromo or iodo, by reacting XXI with N- chlorosuccinimide, N-bromosuccinimide or N-iodosuccinimide. The reaction mixture is heated to reflux, in chloroform, for a time period between about 1 hour to about 3 hours, preferably about 1 hour. Alternatively, in reaction 1 of Preparation A, the 4- chloropyrrolo[2,3-d]pyrimidine of formula XXI, wherein R is hydrogen, is converted to the corresponding 4-chloro-5-nitropyrrolo[2,3-d]pyrimidine of formula XX, wherein Y is nitro, by reacting XXI with nitric acid in sulfuric acid at a temperature between about - 10°C to about 10°C, preferably about 0°C, for a time period between about 5 minutes to about 15 minutes, preferably about 10 minutes. The compound of formula XXI, wherein Y is nitro, is converted to the corresponding 4-chloro-5-aminopyrrolo[2,3- djpyrimidine of the formula XX, wherein Y is amino, by reacting XXI under a variety of conditions known to one skilled in the art such as palladium hydrogenolysis or tin(IV)chloride and hydrochloric acid. In reaction 2 of Preparation A, the 4-chloro-5-halopyrrolo[2,3-d]pyrimidine compound of formula XX, wherein R is hydrogen, is converted to the corresponding compound of formula XIX, wherein R 2 is (C C 6 )alkyl or benzyl, by treating XX with N- butyllithium, at a temperature of about -78°C, and reacting the dianion intermediate so formed with an alkylhalide or benzylhalide at a temperature between about -78°C to room temperature, preferably room temperature. Alternatively, the dianion so formed is reacted with molecular oxygen to form the corresponding 4-chloro-5- hydroxypyrrolo[2,3-d]pyrimidine compound of formula XIX, wherein R 2 is hydroxy. The compound of formula XX, wherein Y is bromine or iodine and R is benzenesulfonate, is converted to the compound of formula XIX, wherein R 2 is (C 6 - C 12 )aryl or vinyl, by treating XX with N-butyllithium, at a temperature of about -78°C, followed by the addition of zinc chloride, at a temperature of about -78°C. The corresponding organo zinc intermediate so formed is then reacted with aryliodide or vinyl iodide in the presence of a catalytic quantity of palladium. The reaction mixture is stirred at a temperature between about 50°C to about 80°C, preferably about 70°C, for a time period between about 1 hour to about 3 hours, preferably about 1 hour. ln reaction 3 of Preparation A, the compound of formula XIX is converted to the corresponding compound of formula XVI by treating XIX with N-butyllithium, lithium diisopropylamine or sodium hydride, at a temperature of about -78°C, in the presence of a polar aprotic solvent, such as tetrahydrofuran. The anionic intermediate so formed is further reacted with (a) alkylhalide or benzylhalide, at a temperature between about -78°C to room temperature, preferably -78°C, when R 3 is alkyl or benzyl; (b) an aldehyde or ketone, at a temperature between about -78°C to room temperature, preferably -78°C, when R 3 is alkoxy; and (c) zinc chloride, at a temperature between about -78°C to room temperature, preferably -78°C, and the corresponding organozinc intermediate so formed is then reacted with aryliodide or vinyl iodide in the presence of a catalytic quantity of palladium. The resulting reaction mixture is stirred at a temperature between about 50°C to about 80°C, preferably about 70°C, for a time period between about 1 hour to about 3 hours, preferably about 1 hour. Alternatively, the anion so formed is reacted with molecular oxygen to form the corresponding 4-chloro-6-hydroxypyrrolo[2,3- djpyrimidine compound of formula XVI, wherein R 3 is hydroxy. In reaction 1 of Preparation B, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XXI is converted to the corresponding compound of formula XXII, according to a procedure analogous to that described above in reaction 3 of Preparation A. In reaction 2 of Preparation B, the compound of formula XXII is converted to the corresponding compound of formula XVI, according to procedures analogous to that described above in reactions 1 and 2 of Preparation A. In reaction 1 of Preparation C, the 4-methylpyridine compound of formula XXXI is converted to the corresponding compound of formula XXX by first alkylating XXXI with benzylchloride in the presence of a polar aprotic solvent, such as acetone. The reaction mixture is stirred at a temperature between about 40°C to about 80°C for a time period between about 4 hours to about 24 hours. The pyridinium intermediate so formed is then reduced with a reducing agent, such as sodium borohydride, in the presence of a polar protic solvent, such as methanol, ethanol, water or mixtures thereof. The reaction is stirred at a temperature between about 0°C to a about room temperature, for a time period between about 18 hours to 24 hours. In reaction 2 of Preparation C, the compound of formula XXX is converted to the corresponding compound of formula XXIX by treating XXX with borotrifluoride etherate in the presence of a reducing agent and an aprotic solvent, such as tetrahydrofuran. The reaction mixture is stirred at a temperature between about 0°C to room temperature, for a time period between about 1 hour to about 3 hours. The intermediate complex so formed is then basified with aqueous sodium hydroxide and then treated with an oxidizing agent, such as hydrogen peroxide or Oxone®^ at a temperature between about 0°C to room temperature, for a time period between about 12 hours to about 24 hours. In reaction 3 of Preparation C, the compound of formula XXIX is treated with an oxidizing agent, such as chromium oxide or dimethylsulfoxide, oxalylchloride or SO 3 -pyridine complex, for a time period between about 1 hour to 3 hours, at ambient temperature. The ketone intermediate so formed, is then treated with an amine (R 4 - NH 2 ) in the presence of an acid, such as acetic acid, at about room temperature, for a time period between about 2 to about 24 hours, in an organic solvent such as methanol, ethanol or tetrahydrofuran. The corresponding imine intermediate so formed is then treated with a reducing agent, such as sodium borohydride or sodium cyanoborohydride or sodium triacetoxyborohydride, at ambient temperature, for a time period about 2 to about 24 hours. In reaction 1 of Scheme 1 , the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XVII is converted to the corresponding compound of formula XVI, wherein R is benzenesulfonyl or benzyl, by treating XVII with benzenesulfonyl chloride, benzylchloride or benzylbromide in the presence of a base, such as sodium hydride or potassium carbonate, and a polar aprotic solvent, such as dimethylformamide or tetrahydrofuran. The reaction mixture is stirred at a temperature between about 0°C to about 70°C, preferably about 30°C, for a time period between about 1 hour to about 3 hours, preferably about 2 hours. In reaction 2 of Scheme 1 , the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XVI is converted to the corresponding 4-aminopyrrolo[2,3-d]pyrimidine compound of formula XV by coupling XVI with an amine of the formula HNR 4 R 5 . The reaction is carried out in an alcohol solvent, such as tert-butanol, methanol or ethanol, or other high boiling organic solvents, such as dimethylformamide, triethylamine, 1 ,4- dioxane or 1 ,2-dichloroethane, at a temperature between about 60°C to about 120°C, preferably about 80°C. Typical reaction times are between about 2 hours to about 48 hours, preferably about 16 hours. When R 5 is a nitrogen containing heterocycloalkyl group, each nitrogen must be protected by a protecting group, such a benzyl. Removal of the R 5 protecting group is carried out under conditions appropriate for that particular protecting group in use which will not affect the R protecting group on the pyrrolo[2,3-d]pyrimidine ring. Removal of the R 5 protecting group, when benzyl, is carried out in an alcohol solvent, such as ethanol, in the present of hydrogen and a catalyst, such as palladium hydroxide on carbon. The R 5 nitrogen containing hetrocycloalkyl group so formed may be further reacted with a variety of different electrophiles of formula II. For urea formation, electrophiles of formula II such as isocyanates, carbamates and carbamoyl chlorides are reacted with the R 5 nitrogen of the heteroalkyl group in a solvent, such as acetonitrile or dimethylformamide, in the presence of a base, such as sodium or potassium carbonate, at a temperature between about 20°C to about 100°C for a time period between about 24 hours to about 72 hours. For amide and sulfonamide formation, electrophiles of formula II, such as acylchlorides and sulfonyl chlorides, are reacted with the R 5 nitrogen of the heteroalkyl group in a solvent such as methylene chloride in the presence of a base such as pyridine at ambient temperatures for a time period between about 12 hours to about 24 hours. Amide formation may also be carried out by reacting a carboxylic acid with the heteroalkyl group in the presence of a carbodiimide such as 1-(3- dimethylaminopropyl)-3-ethylcarbodiimide in a solvent such as methylene chloride at ambient temperatures for 12-24 hours. For alkyl formation, electrophiles of formula II, such as α,β-unsaturated amides, acids, nitriles, esters, and α-halo amides, are reacted with the R 5 nitrogen of the heteroalkyl group in a solvent such as methanol at ambient temperatures for a time period between about 12 hours to about 18 hours. Alkyl formation may also be carried out by reacting aldehydes with the heteroalkyl group in the presence of a reducing agent, such as sodium cyanoborohydride, in a solvent, such as methanol, at ambient temperature for a time period between about 12 hours to about 18 hours. In reaction 3 of Scheme 1 , removal of the protecting group from the compound of formula XV, wherein R is benzenesulfonyl, to give the corresponding compound of formula I, is carried out by treating XV with an alkali base, such as sodium hydroxide or potassium hydroxide, in an alcohol solvent, such as methanol or ethanol, or mixed solvents, such as alcohol/tetrahydrofuran or alcohol/water. The reaction is carried out at room temperature for a time period between about 15 minutes to about 1 hour, preferably 30 minutes. Removal of the protecting group from the compound of formula XV, wherein R is benzyl, is conducted by treating XV with sodium in ammonia at a temperature of about -78°C for a time period between about 15 minutes to about 1 hour. In reaction 1 of Scheme 2, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XX is converted to the corresponding 4-aminopyrrolo[2,3-d]pyrimidine compound of formula XXIV, according to a procedure analogous to that described above in reaction 2 of Scheme 1. In reaction 2 of Scheme 2, the 4-amino-5-halopyrrolo[2,3-d]pyrimidine compound of formula XXIV, wherein R is benzenesulfonate and Z is bromine or iodine, is converted to the corresponding compound of formula XXIII by reacting XXIV with (a) arylboronic acid, when R 2 is aryl, in an aprotic solvent, such tetrahydrofuran or dioxane, in the presence of a catalytic quantity of palladium (0) at a temperature between about 50°C to about 100°C, preferably about 70°C, for a time period between about 2 hours to about 48 hours, preferably about 12 hours; (b) alkynes, when R 2 is alkynyl, in the presence of a catalytic quantity of copper (I) iodide and palladium (0), and a polar solvent, such as dimethylformamide, at room temperature, for a time period between about 1 hour to about 5 hours, preferably about 3 hours; and (c) alkenes or styrenes, when R 2 is vinyl or styrenyl, in the presence of a catalytic quantity of palladium in dimethylformamide, dioxane or tetrahydrofuran, at a temperature between about 80°C to about 100°C, preferably about 100°C, for a time period between about 2 hours to about 48 hours, preferably about 48 hours. In reaction 3 of Scheme 2, the compound of formula XXIII is converted to the corresponding compound of formula XV, according to a procedure analogous to that described above in reaction 3 of Preparation A. In reaction 1 of Scheme 3, the compound of formula XVII is converted to the corresponding compound of formula I, according to a procedure analogous to that described above in reaction 2 of Scheme 1. The compounds of the present invention that are basic in nature are capable of forming a wide variety of different salts with various inorganic and organic acids. Although such salts must be pharmaceutically acceptable for administration to animals, it is often desirable in practice to initially isolate the compound of the present invention from the reaction mixture as a pharmaceutically unacceptable salt and then simply convert the latter back to the free base compound by treatment with an alkaline reagent and subsequently convert the latter free base to a pharmaceutically acceptable acid addition salt. The acid addition salts of the base compounds of this invention are readily prepared by treating the base compound with a substantially equivalent amount of the chosen mineral or organic acid in an aqueous solvent medium or in a suitable organic solvent, such as methanol or ethanol. Upon careful evaporation of the solvent, the desired solid salt is readily obtained. The desired acid salt can also be precipitated from a solution of the free base in an organic solvent by adding to the solution an appropriate mineral or organic acid. Those compounds of the present invention that are acidic in nature, are capable of forming base salts with various pharmacologically acceptable cations. Examples of such salts include the alkali metal or alkaline-earth metal salts and particularly, the sodium and potassium salts. These salts are all prepared by conventional techniques. The chemical bases which are used as reagents to prepare the pharmaceutically acceptable base salts of this invention are those which form non-toxic base salts with the acidic compounds of the present invention. Such non- toxic base salts include those derived from such pharmacologically acceptable cations as sodium, potassium calcium and magnesium, etc. These salts can easily be prepared by treating the corresponding acidic compounds with an aqueous solution containing the desired pharmacologically acceptable cations, and then evaporating the resulting solution to dryness, preferably under reduced pressure. Alternatively, they may also be prepared by mixing lower alkanolic solutions of the acidic compounds and the desired alkali metal alkoxide together, and then evaporating the resulting solution to dryness in the same manner as before. In either case, stoichiometric quantities of reagents are preferably employed in order to ensure completeness of reaction and maximum yields of the desired final product. The compositions of the present invention may be formulated in a conventional manner using one or more pharmaceutically acceptable carriers. Thus, the active compounds of the invention may be formulated for oral, buccal, intranasal, parenteral (e.g., intravenous, intramuscular or subcutaneous) or rectal administration or in a form suitable for administration by inhalation or insufflation. The active compounds of the invention may also be formulated for sustained delivery. For oral administration, the pharmaceutical compositions may take the form of, for example, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose or calcium phosphate); lubricants (e.g., magnesium stearate, talc or silica); disintegrants (e.g., potato starch or sodium starch glycolate); or wetting agents (e.g., sodium lauryl sulphate). The tablets may be coated by methods well known in the art. Liquid preparations for oral administration may take the form of, for example, solutions, syrups or suspensions, or they may be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may be prepared by conventional means with pharmaceutically acceptable additives such as suspending agents (e.g., sorbitol syrup, methyl cellulose or hydrogenated edible fats); emulsifying agents (e.g., lecithin or acacia); non- aqueous vehicles (e.g., almond oil, oily esters or ethyl alcohol); and preservatives (e.g., methyl or propyl p-hydroxybenzoates or sorbic acid). For buccal administration, the composition may take the form of tablets or lozenges formulated in conventional manner. The active compounds of the invention may be formulated for parenteral administration by injection, including using conventional catheterization techniques or infusion. Formulations for injection may be presented in unit dosage form, e.g., in ampules or in multi-dose containers, with an added preservative. The compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulating agents such as suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient may be in powder form for reconstitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use. The active compounds of the invention may also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides. For intranasal administration or administration by inhalation, the active compounds of the invention are conveniently delivered in the form of a solution or suspension from a pump spray container that is squeezed or pumped by the patient or as an aerosol spray presentation from a pressurized container or a nebulizer, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol, the dosage unit may be determined by providing a valve to deliver a metered amount. The pressurized container or nebulizer may contain a solution or suspension of the active compound. Capsules and cartridges (made, for example, from gelatin) for use in an inhaler or insufflator may be formulated containing a powder mix of a compound of the invention and a suitable powder base such as lactose or starch. A proposed dose of the active compounds of the invention for oral, parenteral or buccal administration to the average adult human for the treatment of the conditions referred to above (e.g., rheumatoid arthritis) is 0.1 to 1000 mg of the active ingredient per unit dose which could be administered, for example, 1 to 4 times per day. Aerosol formulations for treatment of the conditions referred to above (e.g., asthma) in the average adult human are preferably arranged so that each metered dose or "puff' of aerosol contains 20 μg to 1000 μg of the compound of the invention. The overall daily dose with an aerosol will be within the range 0.1 mg to 1000 mg. Administration may be several times daily, for example 2, 3, 4 or 8 times, giving for example, 1 , 2 or 3 doses each time. A compound of formula (I) administered in a pharmaceutically acceptable form either alone or in combination with one or more additional agents which modulate a mammlian immune system or with antiinflammatory agents, agents which may include but are not limited to cyclosporin A (e.g. Sandimmune ® or Neoral ® , rapamycin, FK-506 (tacrolimus), leflunomide, deoxyspergualin, mycophenolate (e.g. Cellcept ® , azathioprine (e.g. Imuran ® ), daclizumab (e.g. Zenapax ® ), OKT3 (e.g. Orthocolone ® ), AtGam, aspirin, acetaminophen, ibuprofen, naproxen, piroxicam, and antiinflmmatory steroids (e.g. prednisolone or dexamethasone); and such agents may be administered as part of the same or separate dosage forms, via the same or different routes of administration, and on the same or different administration schedules according to standard pharmaceutical practice. FK506 (Tacrolimus) is given orally at 0.10-0.15 mg/kg body weight, every 12 hours, within first 48 hours postoperative. Does is monitored by serum Tacrolimus trough levels. Cyclosporin A (Sandimmune oral or intravenous formulation, or Neoral ® , oral solution or capsules) is given orally at 5 mg/kg body weight, every 12 hours within 48 hours postoperative. Dose is monitored by blood Cyclosporin A trough levels. The active agents can be formulated for sustained delivery according to methods well known to those of ordinary skill in the art. Examples of such formulations can be found in United States Patents 3,538,214, 4,060,598, 4,173,626, 3,119,742, and 3,492,397. The ability of the compounds of formula I or their pharmaceutically acceptable salts to inhibit Janus Kinase 3 and, consequently, demonstrate their effectiveness for treating disorders or conditions characterized by Janus Kinase 3 is shown by the following in vitro assay tests. Biological Assay JAK3 (JH1 :GST) Enzymatic Assay The JAK3 kinase assay utilizes a protein expressed in baculovirus-infected SF9 cells (a fusion protein of GST and the catalytic domain of human JAK3) purified by affinity chromatography on glutathione-Sepaharose. The substrate for the reaction is poly-Glutamic acid-Tyrosine (PGT (4:1), Sigma catalog # P0275), coated onto Nunc Maxi Sorp plates at 100 μg/ml overnight at 37°C. The morning after coating, the plates are washed three times and JAK3 is added to the wells containing 100 μl of kinase buffer (50 mM HEPES, pH 7.3, 125 mM NaCI, 24 mM MgCI2)+ 0.2 uM ATP + 1 mM Na orthovanadate.) The reaction proceeds for 30 minutes at room temperature and the plates is washed three more times. The level of phosphorylated tyrosine in a given well is quantitated by standard ELISA assay utilizing an anti- phosphotyrosine antibody (ICN PY20, cat. #69-151-1). Inhibition of Human IL-2 Dependent T-Cell Blast Proliferation This screen measures the inhibitory effect of compounds on IL-2 dependent T-Cell blast proliferation in vitro. Since signaling through the IL-2 receptor requires JAK-3, cell active inhibitors of JAK-3 should inhibit IL-2 dependent T-Cell blast proliferation. The cells for this assay are isolated from fresh human blood. After separation of the mononuclear cells using Accuspin System-Histopaque-1077 (Sigma # A7054), primary human T-Cells are isolated by negative selection using Lympho-Kwik T (One Lambda, Inc., Cat # LK-50T). T-Cells are cultured at 1-2 x 10 6 /ml in Media (RPMI + 10% heat-inactivated fetal calf serum (Hyclone Cat # A-1111-L) + 1% Penicillin/Streptomycin (Gibco)) and induce to proliferate by the addition of 10ug/ml PHA (Murex Diagnostics, Cat # HA 16). After 3 days at 37°C in 5% CO 2 , cells are washed 3 times in Media, resuspended to a density of 1-2 x 10 6 cells/ml in Media plus 100 Units/ml of human recombinant IL-2 (R&D Systems, Cat # 202-IL). After 1 week the cells are IL-2 dependent and can be maintained for up to 3 weeks by feeding twice weekly with equal volumes of Media + 100 Units/ml of IL-2. To assay for a test compounds ability to inhibit IL-2 dependent T-Cell proliferation, IL-2 dependent cells are washed 3 times, resuspended in media and then plated (50,000 cells/well/0.1 ml) in a Flat-bottom 96-well microtiter plate (Falcon # 353075). From a10 mM stock of test compound in DMSO, serial 2-fold dilutions of compound are added in triplicate wells starting at 10 uM. After one hour, 10 Units/ml of IL-2 is added to each test well. Plates are then incubated at 37°C, 5% CO 2 for 72 hours. Plates are then pulsed with 3 H-thymidine (0.5 uCi/well) (NEN Cat # NET- 027A), and incubated an additional 18 hours. Culture plates are then harvested with a 96-well plate harvester and the amount of 3 H-thymidine incorporated into proliferating cells is determined by counting on a Packard Top Count scintillation counter. Data is analyzed by plotting the % inhibition of proliferation verses the concentration of test compound. An IC 50 value (uM) is determined from this plot. The following Examples illustrate the preparation of the compounds of the present invention but it is not limited to the details thereof. Commercial reagents were utilized without further purification. THF refers to tetrahydrofuran. DMF refers to N,N-dimethylformamide. Low Resolution Mass Spectra (LRMS) were recorded on either a Hewlett Packard 5989®, utilizing chemical ionization (ammonium), or a Fisons (or Micro Mass) Atmospheric Pressure Chemical Ionization (APCI) platform which uses a 50/50 mixture of acetonitrile/water with 0.1% formic acid as the ionizing agent. Room or ambient temperature refers to 20-25°C. Example 1 Furan-2-yl-(4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1- piperidin-1 -vD-methanone Method A 1 -Benzyl-4-methyl-pyridinium chloride To a stirred solution of 4-methylpyridine (26 mL/0.268 mol) in 70 mL of acetone was added 31 mL (0.268 mol) of benzylchloride. The resulting mixture was stirred at 50°C for 18 hours. After cooling to room temperature, the reaction was filtered, washed with acetone and dried under reduced pressure affording 38 g of the title compound. The filtrate was concentrated under reduced pressure producing an additional 5.6 grams of the title compound (74% combined yield). LRMS: 184. Method B 1 -Benzyl-4-methyl-1 ,2,3,6-tetrahydro-pyridine To a stirred solution of the product from Method A (38 grams/0.171 mol) dissolved in 140 mL of 10:1 ethanol/water at 0°C was added 16 grams (0.427 mol) of sodium borohydride portion-wise over 25 minutes. The resulting mixture stirred for 18 hours at room temperature, at which time, the reaction was quenched upon addition of 100 mL of water. The reaction mixture was filtered, the filter cake washed with water and ethylacetate, and the combined filtrates concentrated under reduced pressure to remove the organics. The residue was diluted with water (100 mL) and extracted 3 times with 150 mL with ethylacetate. The combined ethylacetate extracts were dried over Na 2 SO 4 and concentrated to dryness in vacuo affording 32 grams (100%>) of the title compound as a yellow oil. LRMS: 188 (M+1 ). Method C 1-Benzyl-4-methyl-piperidin-3-ol To a solution of the product from Method B (72.45 grams/0.387 mol) dissolved in 240 mL of THF was added 21.4 grams of NaBH 4 and the mixture cooled to 0 °C. A solution of borontrifluoride etherate (109.4 mL dissolved in 200 mL of THF) was then added dropwise over 1.5 hours. Once added, the reaction mixture was brought to room temperature and stirred for 2 hours. The reaction was again cooled to 0 °C and 29.3 mL of water were added dropwise over 15 minutes followed by dropwise addition of 2N sodium hydroxide (97.5 mL) over 20 minutes. The resulting mixture stirred at 0 °C for 40 minutes and was then brought to room temperature. Hydrogen peroxide (30%) (97.5 mL) was added dropwise at a rate so as not to exceed 50 °C in the reaction mixture (approximately 30 minutes). When the addition was complete, the reaction mixture stirred for 10 minutes, then was cooled to 0 °C. Concentrated hydrochloric acid (97.5 mL) was added over 5 minutes, the reaction mixture was reduced to one third its volume in vacuo, and the pH adjusted to 9-10 with 6N sodium hydroxide (aq). The resulting mixture was extracted three times with ether, the combined ether layers dried over MgSO and evaporated to dryness in vacuo affording 65.32 grams (79%) of the title compound as yellow oil. LRMS: 206.1 (M+1). Alternative Method: To a solution of the product from Method B (18.7 grams/0.1 mol) in THF (150mL) was added NaBH (6.5 grams/0.170 mol) at room temperature under N 2 . The slurry was cooled to 0°C, and BF 3 OEt 2 (15mL, 16.8 grams/0.118 mol) in THF (25mL) was slowly added through an addition funnel. The addition was kept slow enough to keep the temperature of the reaction mixture below 0°C. After the addition; the reaction mixture was stirred at 0°C for 1 hour and room temperature for 1.5 hours. The reaction was re-cooled to 0°C and water (50mL) was added slowly to destroy the excess borane. The reaction was stirred at room temperature for 2 hours, followed by the addition of Oxone ® (110 grams/0.343 mol) in water (500mL) at 0°C. The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction was quenched upon addition of solid NaHSO 3 until all excess oxidant was destroyed (Kl/starch test paper). The pH of the reaction mixture was 1-2. The reaction mixture was then extracted 3 times with 50 mL ethyl acetate, the aqueous layer adjusted to pH 12 with 6 N sodium hydroxide and extracted with ethyl acetate (4 times with 100 mL). The organic layer was washed with brine, dried over Na 2 SO 4 , and concentrated in vacuo affording 19.0 grams (92%) of the title compound as an oil. LRMS: 206.1 (M+1). Method D 1-Benzyl-4-methyl-piperidin-3-ol -toluene-4-sulfonic acid salt To a stirred solution of the product from Method C (65.32 grams/0.318 mol) dissolved in 175 mL of acetone and cooled to 0°C was added a solution of para- toluenesulfonic acid monohydrate in 350 mL of acetone (dropwise) over 2 hours and the resulting mixture stirred at 0°C for 1.5 hours. The precipitate was filtered and the filter cake washed with 90 mL of diisopropyl ether. The solid product was then dried in vacuo affording 58.55 grams (100%) of the title compound as a white solid. LRMS: 378.5 (M+1). Method E 1 -Benzyl-4-methyl-piperidin-3-one To a solution of the product from Method D (9.8 grams/0.026 mol) and 31.7 mL of diisopropylethylamine dissolved in 250 mL of dichloromethane and cooled to 0°C was added (dropwise) 12.4 grams of SO 3 pyridine complex dissolved in 153 mL of dimethylsulfoxide over a 40 minute period. Once added, the reaction stirred for 1.5 hours at room temperature and was then quenched upon addition of 200 mL of saturated NaHCO 3 (aq). The dichloromethane was removed in vacuo and the remaining aqueous residue extracted four times with diisopropyl ether (150 mL). The combined ether layers were washed four times with water (100 mL), dried over Na 2 SO 4 and concentrated to dryness in vacuo affording 3.81 grams (72.97%) of the title compound as yellow oil. LRMS: 204 (M+1). Method F (1 -Benzyl-4-methyl-piperidin-3-yl)-methyl-amine To a stirred solution of the product from Method E (3.81 grams/0.019 mol) and 38 mL of 2.0 M methylamine in THF was added 2.2 mL of acetic acid and the resulting mixture stirred at room temperature for 1.5 hours. Triacetoxysodiumborohydride (NaB(OAc) 3 H) (7.94 grams/0.038 mol) was added as a solid and the new mixture stirred at room temperature for 18 hours. The reaction was quenched with 2 N hydrochloric acid and the pH adjusted to 1. The reaction mixture was washed two times with ether, the aqueous layer then adjusted to pH of 12 with 6 N sodium hydroxide (aq) and extracted three times with dichloromethane. The combined dichloromethane layers were dried over Na 2 SO 4ι filtered and evaporated to dryness in vacuo affording 3.51 grams (87.75%) of the title compound as dark yellow oil. LRMS: 219.1 (M+1). Method G (1-Benzyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- amine A mixture of 4-chloropyrrolo[2,3- ]pyrimidine (2.4 grams, 15.9 mmol), prepared by the method of Davoll, J. Am. Chem. Soc, (1960), 82, 131 , the product from Method F (1J grams, 7.95 mmol) and 10 mL of triethylamine were heated in a sealed tube at 100°C for 4 days. After cooling to room temperature and concentration under reduced pressure, the residue was purified by flash chromatography (silica; 3% methanol in dichloromethane) affording 1.0 grams (38%) of the title compound as a colorless oil. LRMS: 336.1 (M+1). Method H Methyl-(4-methyl-piperidin-3-yl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine To the product from Method G (0J grams, 2.19 mmol) dissolved in 15 mL of ethanol was added 0.5 grams of 20% palladium hydroxide on carbon (50% water) (Aldrich) and the resulting mixture agitated (Parr-Shaker) under an atmosphere of hydrogen (50 psi) at room temperature for 2 days. The Celite filtered reaction mixture was concentrated to dryness in vacuo and the residue purified by flash chromatography (silica; 5% methanol in dichoromethane) affording 0.48 grams (90%) of the title compound. LRMS: 246.1 (M+1). Method I [1-(4-Methoxy-benzenesulfonyl)-4-methyl-piperidin-3-yl]-methyl-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-amirte To a stirred solution of 1 mL of pyridine and 9 ml of dichloromethane was added 40 mg (0.163 mmol) of the product from Method H and 20 L of 4-methoxy- benzenesulfonyl chloride and the resulting mixture stirred at room temperature for 18 hours. The reaction was then quenched upon addition of saturated NaHCO (aq), the organic layer was removed and the aqueous layer extracted with dichloromethane. The dichloromethane layer was dried over Na 2 SO 4 and concentrated to dryness in vacuo. The residue was purified by PTLC (silica; 10:1 dichloromethane/methanol) affording 22 mg (32%) of the title compound as a light yellow solid. LRMS: 416.5 (M+1). The title compounds for examples 2-297 were prepared by a method analogous to that described in Example 1. Example 2 ri-(4-Methoxy-benzenesulfonyl)-4-methyl-piperidin-3-vπ-methyl-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 416. Example 3 (1-Benzenesulfonyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolof2,3- dlpyrimidin-4-vP-amine LRMS: 386. Example 4 2-(2-(4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- sulfonyl)-ethyl)-isoindole-1,3-dione LRMS: 483. Example 5 Cyclohexanecarboxylic acid (2-(4-methyl-3-Fmethyl-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amino1-piperidine-1-sulfonyl>-ethyl)-amide RMS: 463. Example 6 2-Chloro-N-(2-(4-methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-ylamino1- piperidine-1-sulfonyl>-ethyl)-benzamide LRMS: 492. Example 7 4-Chloro-N-(2-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- amino1- piperidine-1-sulfonyl>-ethyl)-benzamide LRMS: 492. Example 8 Furan-2-carboxylic acid (2-(4-methyl-3-fmethvi-(7H-pyrrolor2,3-d1pyrimidin-4- yl)-aminol-piperidine-1-sulfonyl)-ethyl)-amide LRMS: 447. Example 9 -Methoxy-N-(2-(4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- aminol- piperidine-1-sulfonyl)-ethyl)-benzamide LRMS: 487. Example 10 lsoxazole-5-carboxylic acid (2-{4-methyl-3-rmethyl-(7H-pyrrolof2,3- dlpyrimidin-4-v0-amino1-piperidine-1-sulfonyl}-ethyl)-amide LRMS: 448. Example 11 2.4-Difluoro-N-(2-f4-methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)- amino1-piperidine-1-sulfonyl)-ethyl)-benzamide LRMS: 493. Example 12 3-Chloro-N-(2-{4-methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)- amino1- piperidine-1-sulfonyl -ethyl)-benzamide LRMS: 492. Example 13 3-Fluoro-N-(2-f4-methyl-3-rmethyl-(7H-Pyrrolor2,3-d1pyrimidin-4-yl)- amino1- piperidine-1-sulfonyl>-ethyl)-benzamid LRMS: 475. Example 14 2-Fluoro-N-(2-f4-methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)- amino1- piperidine-1-sulfonyl>-ethyl)-benzamide LRMS: 475. Example 15 4-Fluoro-N-(2-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)- amino1- piperidine-1-sulfonyl)-ethyl)-benzamide LRMS: 475. Example 16 N-(2-!4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidine- 1-sulfonyl)-ethyl)-benzamide LRMS: 457. Example 17 Cyclopropanecarboxylic acid (2-f4-methyl-3-fmethyl-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amino1-piperidine-1-sulfonyl -ethyl)-amide LRMS: 421. Example 18 Cyclopentanecarboxylic acid (2-f4-methyl-3-rmethyl-f7H-pyrrolor2,3- dlpyrimidin-4-yl)-amino1-piperidine-1-sulfonyl>-ethyl)-amide LRMS: 449. Example 19 Cvclopentyl-f4-methyl-3-fmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)- amino1- piperidin-1 -yl)-methanone LRMS: 342. Example 20 Tetrahydro-furan-2-carboxylic acid (2-f4-methyl-3-rmethyl-(7H-pyrrolor2,3- d1pyrimidin-4-vn-amino1-piperidine-1-sulfonyl -ethyl)-amide LRMS- 451. Example 21 Tetrahydro-furan-3-carboxylic acid (2-(4-methyl-3-rmethyl-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amino1-piperidine-1-sulfonyl>-ethyl)-amide LRMS: 451. Example 22 (4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol- piperidin-1-yl>- (tetrahydro-furan-2-yl)-methanone LRMS: 344. Example 23 f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidin-1-yl)- (tetrahydro-furan-3-yl)-methanone LRMS: 344. Example 24 Cyclohexanecarboxylic acid (3-f4-methyl-3-rmethyl-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amino1-piperidin-1-yl}-3-oxo-propy0-amide LRMS: 427. Example 25 -Cvclopropyl-1-f4-methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidin-1 -yl}-ethanone LRMS: 328. Example 26 2-f4-Methyl-3-fmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1- piperidine-1- carbonyl>-pyrrolidine-1 -carboxylic acid tert-butyl ester LRMS: 443. Example 27 f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dIpyrimidin-4-yl)-aminol- piperidin-1 -yl)- pyrrolidin-2-yl-methanone LRMS: 343. Example 28 1-(2-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidine- 1 -carbonyl)-pyrrolidin-1 -yl)-ethanone hydrochloride LRMS: 385. Example 29 Furan-3-yl-{4-methyl-3-rmethyl-(7H-pyrrolof2,3-dlpyrimidin-4-yl)- amino1- piperidin-1 -yl)-methanone LRMS: 340. Example 30 f4-Methyl-3-rmethyl-(7H-pyrrolof2,3-dlpyrimidin-4-yl)-amino1- piperidin-1 -yl)- Pyridin-2-yl-methanone LRMS: 351. Example 31 {4-Methyl-3-rmethyl-(7H-pyrrolof2,3-dlpyrimidin-4-yl)-amino1- piperidin-1 -yl>- phenyl-methanone LRMS: 350. Example 32 -f4-Methyl-3-fmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1- piperidin-1 -yl>- 2-phenyl-ethanone LRMS: 364. Example 33 -Cvclopropyl-1-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidin-1 -yl>-ethanone hydrochloride LRMS: 364. Example 34 2-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidine-1- carbonyl)-pyrrolidine-1 -carboxylic acid tert-butyl ester LRMS: 443. Example 35 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid benzylamide LRMS: 379. Example 36 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid phenylamide LRMS: 365. Example 37 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid tetrahydro-furan-3-yl ester LRMS: 360. Example 38 1-(4-f4-Methyl-3-fmethyl-(7H-pyrrolor2,3-dlPyrimidin-4-yl)-amino1- piperidine- 1 -carbonvH-piperidin-1 -yl)-ethanone LRMS: 399. Example 39 -Cvclopentyl-1-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidin-1 -yl}-ethanone LRMS: 356. Example 40 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid cyclohexylamide LRMS: 371. Example 41 Azetidin-3-yl-(4-methyl-3-fmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-aminol- piperidin-1 -yl)-methanone trif luoroacetate LRMS: 443. Example 42 {4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-vπ-amino1- piperidin-1-yl)- pyrrolidin-1 -yl-methanone LRMS: 343. Example 43 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-vπ-amino1-piperidine-1- carboxylic acid methyl-phenyl-amide LRMS: 379. Example 44 f4-Methyl-3-rmethyl-(7H-pyrrolof2.3-d1pyrimidin-4-vπ-amino1- piperidin-1 -yl)- morpholin-4-yl-methanone LRMS: 359. Example 45 Methyl-(4-methyl-3,4,5,6-tetrahvdro-2H-ri.2 , 1bipyridinyl-3-vn-(7H-pyrrolor2,3- dlpyrimidin-4-vQ-amine LRMS: 323. Example 46 Methyl-(4-methyl-1-thiazol-2-yl-piperidin-3-yl)-(7H-pyrrolor2,3-d1pyrimidin-4- vD-amine LRMS: 329. Example 47 4-Methyl-3-fmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-vπ-amino1-piperidine-1- carboxylic acid pyridin-3-ylamide LRMS: 366. Example 48 4-Methyl-3-Fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4-fluoro-phenyl)-amide LRMS: 383. Example 49 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4-nitro-phenyl)-amide LRMS: 410. Example 50 4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid (4-methoxy-phenvD-amide LRMS: 395. Example 51 -(f4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1- piperidine-1- carbonyl)-amino)-benzoic acid ethyl ester LRMS: 437. Example 52 f4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1- piperidin-1 -yl>- piperidin-1 -yl-methanone LRMS: 357. Example 53 Methyl-(4-methyl-5 , -nitro-3,4.5.6-tetrahvdro-2H-π,2 , lbipyridinyl-3-yl)-(7H- pyrroloF2,3-d1pyrimidin-4-yl)-amine LRMS: 368. Example 54 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (3-fluoro-phenyl)-amide LRMS: 383. Example 55 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (2,4-difluoro-phenyl)-amide LRMS: 401. Example 56 Methyl-r4-methyl-1-(pyrrolidine-1-suifonyl)-piperidin-3-vn-(7H-pyrrolor2,3- dlpyrimidin-4-yl)-amine LRMS: 379. Example 57 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid (3-methoxy-phenyl)-amide LRMS: 395. Example 58 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid (3-nitro-phenyl)-amide LRMS: 410. Example 59 -f4-Methyl-3-rmethyl-(7H-pyrrolor2.3-dlpyrimidin-4-vπ-aminol- piperidine-1- carbonyl)-pyrrolidine-2-carboxylic acid methyl ester LRMS: 401. Example 60 Methyl-r4-methyl-1-(5-nitro-thiazol-2-yl)-piperidin-3-vn-f7H-pyrrolor2.3- dlpyrimidin-4-vD-amine LRMS: 374. Example 61 4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-vn-amino1-3,4.5,6- tetrahvdro-2H-ri,2'1bipyridinyl-5'-carboxylic acid methyl ester LRMS: 381. Example 62 (4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-3,4,5,6- tetrahvdro-2H-π.2'1bipyridinyl-5'-yl}-methanol LRMS: 353. Example 63 Methyl-r4-methyl-1-(piperidine-1-sulfonyl)-piperidin-3-vn-(7H-pyrrolor2,3- dlpyrimidin-4-vO-annino LRMS: 393. Example 64 4-Methyl-3-fmethyl-(7H-pyrrolor2.3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (3-cyano-phenvD-amide LRMS: 390. Example 65 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-vπ-amino1-piperidine-1- carboxylic acid (3,4-difluoro-phenvD-anr-ide LRMS: 401. Example 66 Methyl-r4-methyl-1-(morpholine-4-sulfonyl)-piperidin-3-vπ-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine LRMS: 395. Example 67 4-Methvi-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4-chloro-phenyl)-amide LRMS: 399. Example 68 Methyl-r4-methyl-1-(6-methyl-pyridazin-3-yl)-piperidin-3-vn-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine LRMS: 338. Example 69 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid (4-cyano-phenvD-amide LRMS: 390. Example 70 4-Methyl-3-Fmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid biphenyl-4-ylamide LRMS: 441. Example 71 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4-trifluoromethyl-phenyl)-amide LRMS: 433. Example 72 Methyl-(2-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- amino1- piperidine-1-sulfonyl)-ethyl)-carbamic acid benzyl ester LRMS: 501. Example 73 Cvclopropyl-(4-methyl-3-rmethyl-(7H-pyrrolor2-3-dlpyrimidin-4-yl)- amino1- piperidin-1 -yl)-methanone LRMS: 314. Example 74 Cvclobutyl-(4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)- amino1- piperidin-1 -yl -methanone LRMS: 328. Example 75 Tetrahydro-furan-3-carboxylic acid methyl-(2-f4-methyl-3-rmethyl-(7H- PVrrolor2,3-dlpyrimidin-4-vπ-amino1-piperidine-1-sulfonyl>-ethyl)-amide LRMS: 465. Example 76 Cyclohexanecarboxylic acid methyl-(2-f4-methyl-3-rmethyl-(7H-pyrrolor2.3- dlpyrimidin-4-yl)-amino]-piperidine-1-sulfonyl>-ethvπ-amide LRMS: 477. Example 77 (5 -Dichloro-1H-indol-2-yl)-(4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4- yl)-amino1-piperidin-1-yl}-methanone LRMS: 458. Example 78 4-(f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidine-1- carbonyl}-amino)-benzoic acid LRMS: 409. Example 79 (1-Benzooxazol-2-yl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine LRMS: 363. Example 80 (1 H-lndol-2-yl)-f4-methyl-3-rmethyl-f7H-pyrrolor2.3-d1pyrimidin-4-yl)-aminol- piperidin-1 -yl)-methanone LRMS: 389. Example 81 (5-Fluoro-1H-indol-2-yl)-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-vn- amino1-piperidin-1-yl)-methanone LRMS: 407. Example 82 (5-Methoxy-3-methyl-benzofuran-2-yl)-f4-methyl-3-rmethyl-(7H-pyrrolor2,3- dTpyrimidin-4-yl)-amino1-piperidin-1-yl)-methanone LRMS: 434. Example 83 (5-Chloro-benzofuran-2-yl)-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4- yl)-amino1-piperidin-1-yl>-methanone LRMS: 424. Example 84 {4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidin-1 -v\\- (5-nitro-benzofuran-2-yl)-methanone LRMS: 435. Example 85 (5-Chloro-2,3-dihvdro-benzofuran-2-yl)-f4-methyl-3-rmethyl-(7H-pyrrolor2.3- dlpyrimidin-4-yl)-amino1-piperidin-1-yl)-methanone LRMS: 426. Example 86 (4-Hvdroxy-piperidin-1-yl)-{4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4- vD-amino1-piperidin-1-yl)-methanone LRMS: 373. Example 87 1-(2-(4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1- piperidine- 1-carbonyl)-benzofuran-5-yl)-ethanone LRMS: 432. Example 88 1-(3-Methyl-2-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- amino1- piperidine-1 -carbonyl>-1 H-indol-5-yl)-ethanone LRMS: 445. Example 89 f1-(5-Chloro-benzothiazol-2-yl)-4-methyl-piperidin-3-vπ-methyl-(7H- pyrrolo r 2,3-dlpyrimidin-4-yl)-amine LRMS: 413. Example 90 (3-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol- piperidine-1- carbonyl)-3-aza-bicvclor3.1.01hex-6-yl)-carbamic acid tert-butyl ester LRMS: 470. xample 91 -(4-Chloro-phenoxy)-1-(4-methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)- aminol-piperidin-1 -ylV-propan-1 -one LRMS: 428. Example 92 4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid pyridin-2-ylamide LRMS: 366. Example 93 1 -(4-Methyl-3-rmethvi-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1- piperidine-1 - carbonyl)-piperidine-4-carboxylic acid amide hydrochloride LRMS: 436. Example 94 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (5-chloro-pyridin-2-yl)-amide LRMS: 400. Example 95 3-(4-Methyl-3-fmethyl-(7H-pyrrolof2,3-dlpyrimidin-4-yl)-amino1- piperidine-1 - carbonyD-cyclopentanone LRMS: 356. Example 96 (3-Hvdroxy-cvclopentyl)-{4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-vπ- amino1-piperidin-1-yl)-methanone LRMS: 358. Example 97 4-{4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1- piperidine-1 - carbonvD-cyclohexanone LRMS: 370. Example 98 3-f4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidine-1 - carbonvD-cyclohexanone LRMS: 370. Example 99 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperid»ne-1- carboxylic acid (5-nitro-pyridin-2-yl)-amide LRMS: 413. Example 100 r4-(f4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1- piperidine-1 - carbonyl)-amino)-phenyll-acetic acid LRMS: 423. Example 101 (4-Amino-p8peridin-1-yl)-f4-methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)- aminol-piperidin-1 -v -methanone hydrochloride LRMS: 408. Example 102 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (6-methyl-pyridin-2-yl)-amide LRMS: 380. Example 103 1-Methyl-4-(4-methyl-3-Fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- amino1- piperidine-1-carbonvD-pyrrolidin-2-one LRMS: 371. Example 104 1-Benzyl-3-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- aminol- piperidine-1-carbonvD-pyrrolidin-2-one LRMS: 447. Example 105 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide LRMS: 434. Example 106 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol- cyclohexanecarboxylic acid (4-cvano-phenyl)-amide LRMS: 389. Example 107 4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4-carbamoyl-phenyl)-amide LRMS: 408. Example 108 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4-sulfamoyl-phenyl)-amide LRMS: 444. Example 109 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (5-methyl-thiazol-2-yl)-amide LRMS: 386. Example 110 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (5,6-dichloro-benzothiazol-2-yl)-amide LRMS: 491. Example 111 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid (4-methyl-thiazol-2-yl)-amide LRMS: 386. Example 112 Azetidin-1-yl-(4-methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-vπ-amino1- piperidin-1 -v -methanone hydrochloride LRMS: 365. Example 113 r2-((4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidine-1- carbonyD-amino)-thiazol-4-vn-acetic acid ethyl ester LRMS: 458. Example 114 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4,5-dimethyl-thiazol-2-yl)-amide LRMS: 400. Example 115 r2-({4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidine-1- carbonvD-amino)-thiazol-4-yll-acetic acid LRMS: 430. Example 116 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid benzothiazol-2-ylamide LRMS: 422. Example 117 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid thiazol-2-ylamide LRMS: 372. Example 118 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid r6-(2-dimethylamino-ethylamino)-pyridin-3-yll-amide LRMS: 452. Example 119 N-(4-Chloro-phenvD-2-(4-methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)- aminol-piperidin-1-vD-acetamide LRMS: 413. Example 120 N,N-Dimethyl-2-{4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidin-1 -yl>-acetamide LRMS: 331. Example 121 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid r6-(2-pyrrolidin-1-yl-ethylamino)-pyridin-3-yl1-amide LRMS: 478. Example 122 f2-r5-(f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine- 1-carbonvD-amino)-pyridin-2-yloxy1-ethvD-carbamic acid tert-butyl ester LRMS: 525. Example 123 4-Methyl-3-rmethyl-(7H-pyrrolor2.3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid f6-(2-amino-ethoxy)-pyridin-3-vn-amide LRMS: 425. Example 124 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4-methylsulfamoyl-phenvD-amide LRMS: 458. Example 125 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (4-methanesulfonyl-phenvD-amide LRMS: 443. Example 126 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (5-methyl-ri,3,41thiadiazol-2-yl)-amide LRMS: 387. Example 127 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1- piperidine-1 - carboxylic acid (4-methylsulfamoyl-phenvD-amide hydrochloride LRMS: 495. Example 128 Methyl-r4-methyl-1-(1-phenyl-ethyl)-piperidin-3-vn-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amine LRMS: 350. Example 129 (3-Hvdroxy-pyrrolidin-1-yl)-{4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4- vQ-aminol-piperidin-1-vD-methanone LRMS: 359. Example 130 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid tert-butyl ester LRMS: 346. Example 131 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid r4-(2-dimethylamino-ethyl)-thiazol-2-yll-amide LRMS: 443. Example 132 4-Methyl-3-fmethyl-(7H-pyrrolof2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid 4-methanesulfonyl-benzylamide LRMS: 457. Example 133 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-vπ-amino1-piperidine-1- carboxylic acid (4-acetylsulfamoyl-phenvD-amide LRMS: 486. Example 134 -f4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- 2-phenyl-ethane-1 ,2-dione LRMS: 378. Example 135 Methyl-r4-methyl-1- 6-methylamino-pyrimidin-4-yl)-piperidin-3-vn-(7H- PVrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 353. Example 136 Methyl-f4-methyl-1-(6-pyrrolidin-1-yl-pyrimidin-4-yl)-piperidin-3-vn-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 393. Example 137 f1-(6-Benzylamino-pyrimidin-4-yl)-4-methyl-piperidin-3-vπ-methyl-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 429. Example 138 N,N-Dimethyl-N'-(6-(4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- aminol-piperidin-1 -vD-pyrimidin-4-yl)-ethane-1 ,2-diamine LRMS: 410. Example 139 ri-(6-Chloro-pyrimidin-4-yl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine LRMS: 358. Example 140 ri-(2-Fluoro-benzyl)-4-methyl-piperidin-3-yll-methyl-(7H-pyrrolor2.3- dlpyrimidin-4-vD-amine LRMS: 354 Example 141 ri-(2-Chloro-pyrimidin-4-yl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amine LRMS: 359. Example 142 ri-(4-Chloro-pyrimidin-2-vD-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine LRMS: 359. Example 143 Methyl-r4-methyl-1-(2-methylamino-pyrimidin-4-yl)-piperidin-3-vn- 7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 353. Example 144 Methyl-r4-methyl-1-(4-pyrrolidin-1-yl-pyrimidin-2-yl)-piperidin-3-vn-(7H- PVrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 353. Example 145 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (3-methyl-isoxazol-5-yl)-amide LRMS: 370. Example 146 4-Methyl-3-fmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (3-methyl-isoxazol-4-yl)-amide LRMS: 370. xample 147 4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (5-methyl-isoxazol-3-yl)-amide LRMS: 370. Example 148 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide LRMS: 412. Example 149 4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid isoxazol-3-ylamide LRMS: 356. Example 150 N-Methyl-3-(4-methyl-3-rmethyl-(7H-pyrroloF2,3-d1pyrimidin-4-yl)-aminol- piperidin-1 -vD-propionamide LRMS: 331. Example 151 -(4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- propan-2-one LRMS: 302. Example 152 f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- oxo-acetic acid methyl ester LRMS: 332. Example 153 (1-Cvclohexylmethyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine LRMS: 342. Example 154 ri-(5-Amino-thiazol-2-yl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2.3- dlpyrimidin-4-vP-amine LRMS: 344. Example 155 Methyl-(4-methyl-piperidin-3-yl)-(7H-pyrrolor2,3-d1pyrimidin-4-vD-amine LRMS: 246. Example 156 -f4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-aminol-piperidin-1-ylV- 3-oxo-propionic acid methyl ester LRMS: 346. Example 157 (1-Benzenesulfonylmethyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolo r 2,3- dlpyrimidin-4-yl)-amine LRMS: 400. Example 158 (3-Hvdroxy-pyrrolidin-1-yl)-(4-methyl-3-fmethyl-(7H-pyrrolor2.3-dlpyrimidin-4- yl)-amino1-piperidin-1-vD-methanone LRMS: 359. Example 159 1-f4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- propane-1,2-dione LRMS: 316. Example 160 4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (6-sulfamoyl-pyridin-3-yl)-amide LRMS: 445. Example 161 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (6-acetylamino-pyridin-3-yl)-amide LRMS: 423. Example 162 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid r4-(2-dimethylamino-ethylsulfamoyl)-phenvn-amide LRMS: 515. Example 163 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (6-cyano-pyridin-3-yl)-amide LRMS: 391. Example 164 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-3,4,5,6- tetrahydro-2H-π .2'1bipyridinyl-5'-sulfonic acid pyridin-2-ylamide LRMS: 479. Example 165 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid r6-(pyrrolidine-1-carbonyl)-pyridin-3-vn-amide LRMS: 463. Example 166 -lmidazol-1-yl-1-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol- piperidin-1 -v -ethanone LRMS: 354. Example 167 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-3.4,5.6- tetrahvdro-2H-ri.2'1bipyridinyl-5'-carboxylic acid methylamide LRMS: 380. Example 168 (4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-3.4.5.6- tetrahvdro-2H-ri-2'1bipyridinyl-5'-vD-morpholin-4-yl-methanone LRMS: 436. Example 169 5-(f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carbonyD-amino)-pyridine-2-carboxylic acid propylamide LRMS: 451. Example 170 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-3,4,5.6- tetrahydro-2H-π,2'1bipyridinyl-5'-carboxylic acid amide LRMS: 366. Example 171 4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1-3.4.5.6- tetrahvdro-2H-ri .2'1bipyridinyl-5'-carbonitrile LRMS: 348. Example 172 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid r4-(pyrrolidine-1-sulfonyl)-phenvn-amide LRMS: 498. Example 173 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid r4-(morpholine-4-sulfonyi)-phenvn-amide LRMS: 514. Example 174 (3-Hvdroxy-pyrrolidin-1-yl)-f4-methyl-3-fmethyl-(7H-pyrrolof2.3-d1pyrimidin-4- yl)-amino1-piperidin-1-vD-methanone LRMS: 359. Example 175 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid r6-(morpholine-4-carbonyl)-pyridin-3-yll-amide LRMS: 479. Example 176 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid r6-(morpholine-4-carbonyl)-pyridin-3-vπ-amide LRMS: 479. Example 177 -lmidazol-1-yl-1-(4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimid8n-4-yl)-amino1- piperidin-1 -vD-ethanone . LRMS: 354. Example 178 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid isoxazol-3-ylamide LRMS: 356. Example 179 4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (2.5-dimethyl-2H-pyrazol-3-yl)-amide LRMS: 383. Example 180 4-Methyl-3-fmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (5-cvclopropyl-2-methyl-2H-pyrazol-3-yl)-amide LRMS: 409. Example 181 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-vD-amino1-piperidine-1- carboxylic acid (3-methyl-isothiazol-5-yl)-amide LRMS: 386. Example 182 4-(4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidin-1- ylmethv -benzoic acid . LRMS: 380. Example 183 Methyl-r4-methyl-5'-(pyrrolidine-1-sulfonyl)-3,4.5.6-tetrahydro-2H- ri,2'1bipyridinyl-3-vn-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amine LRMS: 456. Example 184 4-Methyl-3-rmethyl-(7H-pyrrolor2.3-dlpyrimidin-4-vn-amino1-3,4,5,6- tetrahvdro-2H-ri,2'1bipyridinyl-5'-sulfonic acid methylamide LRMS: 416. Example 185 4-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1- ylmethvD-benzenesulfonamide LRMS: 415. Example 186 N-tert-Butyl-4-{4-methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-aminol- piperidin-1 -ylmethvD-benzenesulfonamide LRMS: 472. Example 187 -f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- 2-pyrazol-1 -yl-ethanone LRMS: 354. Example 188 Methyl-r4-methyl-1-(5-nitro-benzooxazol-2-yl)-piperidin-3-vn-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine LRMS: 408. Example 189 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-3.4.5.6- tetrahydro-2H-ri,2'1bipyridinyl-5'-sulfonic acid (2-hydroxy-ethyl)-amide LRMS: 446. Example 190 N-tert-Butyl-4-f4-methyl-3-fmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1- piperidin-1 -ylmethvD-benzenesulfonamide LRMS: 471. Example 191 N-Methyl-2-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1- piperidin-1 -vD-2-oxo-acetamide RMS: 331. Example 192 ri-(5-Ethanesulfonyl-benzooxazol-2-vD-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 455. Example 193 Methyl-r4-methyl-1-(5-methyl-benzooxazol-2-yl)-piperidin-3-vn-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 377. Example 194 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-vD-aminol-piperidine-1- carboxylic acid (6-chloro-pyridin-3-yl)-amide LRMS: 400. Example 195 Methyl-(4-methyl-1-quinolin-2-yl-piperidin-3-yl)-(7H-pyrrolor2,3-d1pyrimidin-4- yl)-amine LRMS: 373. Example 196 4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1-3.4.5,6- tetrahvdro-2H-ri,2'1bipyridinyl-5'-sulfonic acid amide LRMS: 402. Example 197 -(4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-vD-amino1-piperidin-1-vD- 2-pyrrolidin-1 -yl-ethane-1 ,2-dione LRMS: 371. Example 198 Methyl-r4-methyl-1-(4-methyl-benzooxazol-2-vD-piperidin-3-vπ-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 377. Example 199 -f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- 2-morpholin-4-yl-ethane-1 ,2-dione LRMS:387. Example 200 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (6-methanesulfonyl-pyridin-3-yl)-amide LRMS: 444. Example 201 4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (6-methanesulfonyl-pyridin-3-yl)-amide LRMS: 444. Example 202 Methyl-r4-methyl-1-(6-nitro-benzooxazol-2-yl)-piperidin-3-vn-(7H-pyrrolor2.3- dlpyrimidin-4-yl)-amine LRMS: 408. Example 203 4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (6-methanesulfonyl-pyridin-3-yl)-amide LRMS: 444. Example 204 4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (6-methanesulfonyl-pyridin-3-yl)-amide LRMS: 444. Example 205 Methyl-r4-methyl-1-(6-nitro-benzooxazol-2-yl)-piperidin-3-vn-(7H-pyrrolof2,3- dlpyrimidin-4-yl)-amine LRMS: 408. Example 206 Methyl-r4-methyl-1-(toluene-3-sulfonyl)-piperidin-3-vn-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amine LRMS: 400. Example 207 Methyl-r4-methyl-1-(4-trifluoromethyl-benzenesulfonyl)-piperidin-3-vπ-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 454. Example 208 (1-Benzothiazol-2-yl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolor2.3- d1pyrimidin-4-yl)-amine LRMS: 379. Example 209 ri-(5,7-Dimethyl-benzooxazol-2-yl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 391. Example 210 -f4-Methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-vD-amino1-piperidin-1-yl}- benzooxazole-6-carboxylic acid methyl ester LRMS: 421. Example 211 Methyl-f4-methyl-1-(6-methyl-benzooxazol-2-yl)-piperidin-3-vπ-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 377. Example 212 ri-(6-Methoxy-benzooxazol-2-yl)-4-methyl-piperidin-3-yll-methyl-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 393. Example 213 Methyl-r4-methyl-1-(5-trifluoromethyl-benzothiazol-2-yl)-piperidin-3-vn-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 447. Example 214 f1-(5J-Dichloro-benzooxazol-2-vD-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 432. Example 215 ri-(6-Chloro-pyridine-3-sulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2.3-dlpyrimidin-4-yl)-amine LRMS: 422. Example 216 ri- 4-Chloro-benzenesulfonyl)-4-methyl-piperidin-3-yll-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-yl)-amine LRMS: 421. Example 217 ri-(4-Fluoro-benzenesulfonyl)-4-methvi-piperidin-3-vn-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-vP-amine LRMS: 404. Example 218 4- 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- sulfonv -benzonitrile LRMS: 411. Example 219 4-(4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- sulfonv -benzenesulfonyl fluoride LRMS: 468. Example 220 2-(4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- sulfonv -benzonitrile LRMS- 411. Example 221 1-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- 2-tetrazol-1 -yl-ethanone LRMS: 356. Example 222 Methyl-r4-methyl-1-(2,2,2-trifluoro-ethanesulfonyl)-piperidin-3-vn-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 392. Example 223 ri-(2,6-Difluoro-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolof2.3-d1pyrimidin-4-yl)-amine LRMS: 422. Example 224 π-(4-tert-Butyl-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 442. Example 225 ri-(2,4-Difluoro-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 422. Example 226 Methyl-r4-methyl-1-(2-trifluoromethyl-benzenesulfonvD-piperidin-3-vn-(7H- Pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 454. Example 227 ri-(3,5-Bis-trifluoromethyl-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl- (7H-pyrrolor2,3-d1pyrimidin-4-vD-amine LRMS: 522. Example 228 ri-(3,5-Dichloro-benzenesulfonvD-4-methyl-piperidin-3-vn-methyl-(7H- PVrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 455. Example 229 4-f4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- sulfonvD-benzoic acid LRMS: 431. Example 230 f1-(6-Chloro-pyridine-3-sulfonyl)-4-methyl-piperidin-3-vπ-methyl-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 422. Example 231 ri-(4-Chloro-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-vQ-amine LRMS: 421. Example 232 f1-(4-Fluoro-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-f7H-pyrrolor2,3- dlpyrimidin-4-vO-amine LRMS: 404. Example 233 4-{4-Methyl-3-rmethyl-(7H-pyrroloF2,3-d1pyrimidin-4-vD-amino1-piperidine-1- sulfonv -benzonitrile LRMS: 411. Example 234 4-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine-1- sulfonv -benzenesulfonyl fluoride LRMS: 468. Example 235 2-(4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- sulfonv -benzonitrile LRMS: 411. Example 236 1-{4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidin-1-vD- 2-tetrazol-1 -yl-ethanone LRMS: 356. Example 237 Methyl-f4-methyl-1-(2,2,2-trifluoro-ethanesulfonyl)-piperidin-3-vn-(7H- PVrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 392. Example 238 ri-(2,6-Difluoro-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 422. Example 239 ri-(4-tert-Butyi-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 442. Example 240 ri-(2,4-Difluoro-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-dlpyrimidin-4-v0-amine LRMS: 422. Example 241 Methyl-f4-methyl-1-(2-trifluoromethyl-benzenesulfonyl)-piper8din-3-vn-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 454. Example 242 ri-(3,5-Bis-trifluoromethyl-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl- (7H-pyrrolof2,3-d1pyrimidin-4-yl)-amine LRMS: 522. Example 243 ri-(3,5-Dichloro-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H- pyrrolor2,3-d1pyrimidin-4-yl)-amine LRMS: 455. Example 244 4-{4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-vπ-amino1-piperidine-1- sulfonv -benzoic acid LRMS. 431. Example 245 (3-Fluoro-phenyl)-{4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- aminol-piperidin-1-vD-methanone LRMS: 368. Example 246 lsothiazol-4-yl-f4-methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1- piperidin-1 -v -methanone LRMS: 357. Example 247 f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol-piperidin-1-vD- thiophen-3-yl-methanone LRMS: 356. Example 248 f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD-(5- methyl-1H-pyrazol-3-yl)-methanone LRMS: 354. Example 249 (5-Methyl-isoxazol-3-yl)-f4-methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-vD- aminol-piperidin-1-vD-methanone. LRMS: 355. Example 250 (4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD-(5- methyl-thiophen-2-yl)-methanone LRMS: 371. Example 251 (4-Fluoro-phenyl)-f4-methyl-3-fmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)- aminol-piperidin-1-vD-methanone LRMS: 368. Example 252 Methyl-r4-methyl-1-(3-nitro-benzenesulfonyl)-piperidin-3-vn- 7H-pyrrolor2,3- dlpyrimidin-4-yl)-amine LRMS: 431. Example 253 f1-(3-Fluoro-benzenesulfonyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amine LRMS: 404. Example 254 (2-Fluoro-phenvD-f4-methyl-3-fmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)- aminol-piperidin-1-vD-methanone LRMS: 368. Example 255 (1,5-Dimethyl-1H-pyrazol-3-yl)-(4-methyl-3-rmethyl-(7H-pyrrolor2.3- d1pyrimidin-4-yl)-amino1-piperidin-1-vD-methanone LRMS: 368. Example 256 {4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD-(2- methyl-thiazol-4-vπ-methanone LRMS: 371. Example 257 {4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidin-1-vD- thiazol-4-yl-methanone LRMS: 357. Example 258 (4-Methyl-isothiazol-5-yl)-{4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4- yl)-amino1-piperidin-1-yl>-methanone LRMS: 371. Example 259 2,2-Dimethyl-5-(2-{4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-vD- aminoVpiperidin-1 -vD-2-oxo-ethvD-π ,31dioxo-an-4-one LRMS: 403. Example 260 2-Cvclopropyl-N-(2-f4-methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-vD- aminol-piperidine-1-sulfonvD-ethvD-acetamide LRMS: 436. Example 261 N-(2-(4-Methyl-3-fmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidine- 1-sulfonvD-ethyl)-methanesulfonamide LRMS: 432. Example 262 (3-Hvdroxy-pyrrolidin-1-yl)-{4-methyl-3-fmethyl-(7H-pyrrolor2.3-d1pyrimidin-4- yl)-amino1-piperidin-1-vD-methanone LRMS: 359. Example 263 4-{4-Methyl-3-fmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidin-1- ylmethv -benzonitrile LRMS: 362. Example 264 3-{4-Methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- sulfonvD-benzenesulfonyl fluoride LRMS: 469. Example 265 2,2-Pimethyl-5-(2-(4-methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-vD- amino]-piperidin-1 -vD-2-oxo-ethyl)-ri ,31dioxolan-4-one LRMS: 402. Example 266 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid benzyl ester LRMS: 381. Example 267 4-(4-Methyl-3-fmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidin-1- ylmethvD-benzenesulfonamide LRMS: 416. Example 268 ri-(1H-lmidazol-2-ylmethyl)-4-methyl-piperidin-3-vπ-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-vD-amine LRMS: 326. Example 269 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid 2-chloro-benzyl ester LRMS: 415. Example 270 Methyl-[ -methyl-1 -(1 -methyl-1 H-imidazol-2-ylmethyl)-piperidin-3-yll-(7H- pyrrolor2,3-dlpyrimidin-4-yl)-amine LRMS: 340. Example 271 -{4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-vπ-amino1-piperidin-1-vD- 2-phenoxy-ethanone LRMS: 380. Example 272 -(4-Fluoro-phenoxy)-1-{4-methyl-3-fmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- aminol-piperidin-1 -v -ethanone LRMS: 381. Example 273 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-dlpyrimidin-4-vD-amino1-piperidine-1- carboxylic acid 2,2,2-trichloro-ethyl ester LRMS: 420. Example 274 -(2-Chloro-phenoxy)-1-{4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-vn- aminol-piperidin-1 -vD-ethanone LRMS: 415. Example 275 -(3-Chloro-phenoxy)-1-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- aminol-piperidin-1 -yp-ethanone LRMS: 415. Example 276 2-Methanesulfonyl-1-f4-methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-vπ- aminol-piperidin-1 -yp-ethanone LRMS: 367. Example 277 2-(1 ,1 -Dioxo-tetrahvdro-1 $l%6&-thiophen-3-yl)-1 -f4-methyl-3-rmethyl-(7H- PVrrolof2,3-d1pyrimidin-4-yl)-aminoT-piperidin-1-yl>-ethanone LRMS: 407. Example 278 Methyl-r4-methyl-1-(1-phenyl-ethyl)-piperidin-3-vn-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amine LRMS: 351. Example 279 1-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- 2-(toluene-4-sulfonyl)-ethanone LRMS: 443. Example 280 2-Hvdroxy-1-f4-methyl-3-rmethyl-(7H-pyrrolor2.3-d1pyrimidin-4-yl)-amino1- piperidin-1 -vD-ethanone LRMS: 304. Example 281 1-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1-vD- 3-nitro-propan-1 -one LRMS: 347. Example 282 5-f2-{4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidin-1- vD-2-oxo-ethyl)-thiazolidine-2.4-dione LRMS: 404. Example 283 3-Hvdroxy-1-(4-methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1- piperidin-1 -vD-propan-1 -one LRMS: 318. Example 284 N-(4-(4-Methyl-3-rmethyl-(7H-pyrrolof2,3-dlpyrimidin-4-yl)-amino1-piperidin-1- vD-4-oxo-butyl)-methanesulfonamide LRMS: 410. Example 285 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid 2,2-dimethyl-propyl ester LRMS: 360. Example 286 -f4-Methyl-3-fmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-aminol-piperidin-1-vD- 2-(thiazolidine-3-sulfonyl)-ethanone LRMS: 440. Example 287 (3,4-Dihvdroxy-pyrrolidin-1-yl)-f4-methyl-3-fmethyl-(7H-pyrrolor2,3- dlpyrimidin-4-yl)-amino1-piperidin-1-vD-methanone LRMS: 376. Example 288 4-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carbonvD-thiazolidin-2-one LRMS: 376 Example 289 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-aminol-piperid8ne-1- carboxylic acid prop-2-vnyl ester LRMS: 328. Example 290 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (2-cvano-ethyl)-amide LRMS: 342. Example 291 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (2-cyano-ethvD-amide . LRMS: 342. Example 292 1-(4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1-cvclohexyD- ethanone oxime LRMS: 302. Example 293 4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol-piperidine-1- carboxylic acid cyanomethyl-methyl-amide LRMS: 342. Example 294 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid isopropyl ester LRMS: 332. Example 295 4-Methyl-3-rmethyl-(7H-pyrrolof2,3-d1pyrimidin-4-yl)-amino1-piperidine-1- carboxylic acid (2-cyano-ethvD-methyl-amide LRMS: 356. Example 296 4-f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-aminol-piperidin-1- ylmethvD-pyridin-1 -ol LRMS: 355. Example 297 f4-Methyl-3-rmethyl-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-amino1-piperidin-1-vD- acetonitrile LRMS: 285. Example 298 ri-(2-Fluoro-benzyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine Method J To a solution of the product from Method H (50 mg, mmols?) dissolved in 5 mL of methanol was added 154 ul (mmols?) of 2-fluoro-benzaldehyde. The resulting mixture stirred at room temperature for 4 hours, at which time, x mg (y mmol) of sodium cyanoborohydride were added and the new mixture stirred at room temperature for 18 hours. The reaction was quenched upon addition of 2 drops of 1 N NaOH (aq) and the mixture concentrated under reduced pressure to remove the methanol. The residue was dissolved in chloroform and washed with water. The aqueous layer was back washed three times with chloroform, the combined chloroform extracts dried over MgSO 4 and concentrated to dryness in vacuo. The crude product was then purified by flash chromatography (silica; 2.5% methanol in chloroform) affording 36 mg (47.5%) of the title compound as a white solid. LRMS: 372.4 (M+1). The title compounds for examples 299-324 were prepared by the method analogous to that described in Example 298. Example 299 (1-Benzyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- amine LRMS: 336. Example 300 (1-Furan-2-ylmethyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolo[2,3- dlpyrimidin-4-yl)-amine LRMS: 326. Example 301 r -(4-Methoxy-benzyl)-4-methyl-piperidin-3-vH-methvi-(7H-pyrrolor2,3- dlpyrimidin-4-vD-amine LRMS: 366. Example 302 ri-(4-Fluoro-benzyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-vD-amine LRMS: 354. Example 303 Methyl-(4-methyl-1-pyridin-3-ylmethyl-piperidin-3-yl)-(7H-pyrrolof2 l 3- d1pyrimidin-4-yl)-amine LRMS: 337. Example 304 Methyl-(4-methyl-1-thiazol-2-ylmethyl-piperidin-3-yl)-(7H-pyrrolor2,3- dlpyrimidin-4-vD-amine LRMS: 343. Example 305 Methyl-(4-methyl-1-pyridin-2-ylmethyl-piperidin-3-yl)-(7H-pyrrolof2,3- d1pyrimidin-4-yl)-amine LRMS: 337. Example 306 Methyl-r4-methyl-1-(1-phenyl-ethyl)-piperidin-3-yll-(7H-pyrrolof2,3- dlpyrimidin-4-vD-amine LRMS: 350. Example 307 (1-Benzyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)- amine LRMS: 336. Example 308 (1-Benzyl-4-methyl-piperidin-3-yl)-methyl-(7H-pyrrolo r 2,3-dlpyrimidin-4-yl)- amine LRMS: 336. Example 309 3-(4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidin-1- ylmethvD-benzonitrile LRMS: 361. Example 310 ri-(3-Fluoro-benzyl)-4-methyl-piperidin-3-vπ-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-yl)-amine LRMS: 354. Example 311 ri-(3-Methoxy-benzyl)-4-methyl-piperidin-3-yl1-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-yl)-amine LRMS: 366. Example 312 3-(4-Methyl-3-rmethyl-(7H-pyrrolor2,3-d1pyrimidin-4-yl)-amino1- piperidin-1- ylmethvD-benzoic acid LRMS: 380. Example 313 ri-(2-Fluoro-benzyl)-4-methyl-piperidin-3-vπ-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-yl)-amine LRMS: 354. Example 314 ri-(2,6-Difluoro-benzyl)-4-methyl-piperidin-3-yll-methyl-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amine LRMS: 372. Example 315 Methyl-(4-methyl-1-phenethyl-piperidin-3-yl)-(7H-pyrrolor2,3-dlpyrimidin-4-vD- amine LRMS: 350. Example 316 ri-(2,3-Difluoro-benzyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amine LRMS: 372. Example 317 ri-(3,4-Difluoro-benzyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-vD-amine LRMS: 372. Example 318 ri-(4-Methanesulfonyl-benzyl)-4-methyl-piperidin-3-yll-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-yl)-amine LRMS: 414. Example 319 Methyl-(4-methyl-1-r4-(piperidine-1-sulfonyl)-benzvn-piperidin-3-vD-(7H- pyrrolor2.3-d1pyrimidin-4-yl)-amine LRMS: 483. Example 320 ri-(3,5-Difluoro-benzyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-vD-amine LRMS: 372. Example 321 ri-(3-Chloro-benzyl)-4-methyl-piperidin-3-yll-methyl-(7H-pyrrolor2,3- d1pyrimidin-4-yl)-amine LRMS: 371. Example 322 ri-(3,5-Difluoro-benzyl)-4-methyl-piperidin-3-vπ-methyl-(7H-pyrroloF2,3- dlpyrimidin-4-vD-amine LRMS: 372. Example 323 f1-(3-Chloro-benzyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2,3- dlpyrimidin-4-yl)-amine LRMS: 371. Example 324 ri-(3.5-Dichloro-benzyl)-4-methyl-piperidin-3-vn-methyl-(7H-pyrrolor2.3- d1pyrimidin-4-yl)-amine LRMS: 405.

Claims: Claims 1. A compound of the formula or the pharmaceutically acceptable salt thereof; wherein R 1 is a group of the formula wherein y is 0, 1 or 2; R 4 is selected from the group consisting of hydrogen, (d-C 6 )alkyl, (d- C 6 )alkylsulfonyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (d- C 4 )alkoxy, (d-C 6 )acyloxy, (C 1 -C 6 )alkylamino, ((Cι-C 6 )alkyl) 2 amino, cyano, nitro, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl or (d-C 6 )acylamino; or R 4 is (C 3 -C 10 )cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C C 6 )acyloxy, (C 1 -C 6 )acylamino, (Cι-C 6 )alkylamino, ((d- C 6 )alkyl) 2 amino, cyano, cyano(C C 6 )alkyl, trifluoromethyl(d-C 6 )alkyl, nitro, nitro(C C 6 )alkyl or (C C 6 )acylamino; R 5 is (C 2 -C 9 )heterocycloalkyl wherein the heterocycloalkyl groups must be substituted by one to five groups consisting of carboxy, cyano, amino, deuterium, hydroxy, (C 1 -C 6 )alkyl, (d-C 6 )alkoxy, halo, (C C 6 )acyl, (C 1 -C 6 )alkylamino, amino(d-C 6 )alkyl, (d-C 6 )alkoxy-CO-NH, (C 1 -C 6 )alkylamino-CO- I (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, (d-C 6 )alkylamino, amino(C 1 -C 6 )alkyl, hydroxy(C C 6 )alkyl, (d- C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )acyloxy(C 1 -C 6 )alkyl, nitro, cyano(C C 6 )alkyl, halo(d- C 6 )alkyl, nitro(C C 6 )alkyl, trifluoromethyl, trifluoromethyl(CrC 6 )alkyl, (d- C 6 )acylamino, (C 1 -C 6 )acylamino(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )acylamino, amino(Cι-C 6 )acyl, amino(C 1 -C 6 )acyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylamino(C 1 -C 6 )acyl, ((d- C 6 )alkyl) 2 amino(d-C 6 )acyl, R 15 R 16 N-CO-O-, R 15 R 16 N-CO-(d-C 6 )alkyl, (C C 6 )alkyl- S(O) m , R 15 R 16 NS(O) m , R 15 R 6 NS(O) m (d-C 6 )alkyl, R 15 S(O) m R 16 N, R 15 S(O) m R 16 N(d- C 6 )alkyl wherein m is 0, 1 or 2 and R 15 and R 16 are each independently selected from hydrogen or (C 1 -C 6 )alkyl; and a group of the formula II wherein a is 0, 1 , 2, 3 or 4; b, c, e, f and g are each independently 0 or 1 ; d is O, 1 , 2, or 3; X is S(O) n wherein n is 0, 1 or 2; oxygen, carbonyl or -C(=N-cyano)-; Y is S(O) n wherein n is 0, 1 or 2; or carbonyl; and Z is carbonyl, C(O)O-, C(O)NR- wherein R is hydrogen or (C C 6 )alkyl; or Z is S(O) n wherein n is 0, 1 or 2; R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently selected from the group consisting of hydrogen or (d-C 6 )alkyl optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C C 6 )acyloxy, (d-C 6 )acylamino, (C C 6 )alkylamino, ((C C 6 )alkyl) 2 amino, cyano, cyano(d-C 6 )alkyl, trifluoromethy d-CeJalkyl, nitro, nitro(C C 6 )alkyl or (d-C 6 )acylamino; R 12 is (C 6 -C 10 )aryl, (C 2 -C 9 )heteroaryl, (C 3 -C 10 )cycloalkyl or (C 2 - C 9 )heterocycloalkyl, wherein the aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups are optionally substituted by one to four groups consisting of hydrogen, deuterium, amino, halo, oxo, hydroxy, nitro, carboxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, trifluoromethyl, trifluoromethoxy, (C C 6 )alkyl, (d-C 6 )alkoxy, (C 3 -C 10 )cycloalkyl, (d- C 6 )alkyl-CO-NH-, (d-C 6 )alkoxy-CO-NH-, (d-C 6 )alkyl-CO-NH-(C C 6 )alkyl, (C r C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkoxy, carboxy, carboxy(C C 6 )alkyl, carboxy(C C 6 )alkoxy, benzyloxycarbonyl(d-C 6 )alkoxy, (C C 6 )alkoxycarbonyl(C 1 -C 6 )alkoxy, (C 6 -C 10 )aryl, amino, amino(C C 6 )alkyl, (d- C 6 )alkoxycarbonylamino, (C6-C 10 )aryl(d-C 6 )alkoxycarbonylamino, (d-C 6 )alkylamino, ((C C 6 )alkyl) 2 amino, (C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino(C 1 -C 6 )alkyl, hydroxy, (d-C 6 )alkoxy, carboxy, carboxy(C -C 6 )alkyl, (C C 6 )alkoxycarbonyl, (d- C 6 )alkoxycarbonyl(C.-C 6 )alkyl, (C C 6 )alkoxy-CO-NH-, (d-C 6 )alkyl-CO-NH-, cyano, (C 5 -C 9 )heterocycloalkyl, amino-CO-NH-, (C C 6 )alkylamino-CO-NH-, ((C C 6 )alkyl) 2 amino-CO-NH-, (C 6 -C 10 )arylamino-CO-NH-, (C 5 -C 9 )heteroarylamino-CO- NH-, (C 1 -C 6 )alkylamino-CO-NH-(C 1 -C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino-CO-NH-(C 1 - C 6 )alkyl, (C 6 -C 10 )arylamino-CO-NH-(C 1 -C 6 )alkyl, (C 5 -C 9 )heteroarylamino-CO-NH-(C 1 - C 6 )alkyl, (C C 6 )alkylcyano, (C 1 -C 6 )alkylcarboxy(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkylcarboxy, sulfonylamino, aminosulfonyl, sulfonylamino(CrC 6 )alkyl, sulfonylaminocarboxy(C 1 - C 6 )alkyl, (C C 6 )alkylsulfonyl, (C C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylsulfonylamino(C 1 - C 6 )alkyl, (C 6 -C 10 )arylsulfonyl, (C 6 -Cι 0 )arylsulfonylamino, (C 6 -Cι 0 )arylsulfonylamino(Cι- C 6 )alkyl, (d-C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylsulfonylamino(C 1 -C 6 )alkyl, (C 3 - C 10 )cycloalkyl, (C 3 -C 10 )cycloalkoxy, (C C 6 )alkylamino, ((C C 6 )alkyl) 2 amino, (C 6 - C 10 )arylamino, (C C 6 )alkylthio, (C 6 -C 10 )arylthio, (C C 6 )alkylsulfinyl, (C 6 - C 10 )arylsulfinyl, (C C 6 )alkylsulfonyl, (C 6 -C 10 )arylsulfonyl, (d-C 6 )acyl, (C r C 6 )alkoxy- CO-NH-, (d-CeJalkyamino-CO-, (C 5 -C 9 )heteroaryl, (C 2 -C 9 )heterocycloalkyl or (C 6 - C 10 )aryl wherein the heteroaryl, heterocycloalkyl and aryl groups which are optionally substituted on R 12 may be further substituted by one to three groups consisting of halo, (C C 6 )alkyl, (C C 6 )alkyl-CO-NH-, (C C 6 )alkoxy-CO-NH-, (C C 6 )alkyl-CO-NH- (d-Ce)alkyl, (C 1 -C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkyl, (Cι-C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkoxy, carboxy, carboxy(C 1 -C 6 )alkyl, carboxy(C 1 -C 6 )alkoxy, benzyloxycarbonyl(CrC 6 )alkoxy, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkoxy, (C 6 -C 10 )aryl, amino, amino(C C 6 )alkyl, (C C 6 )alkoxycarbonylamino, (Ce-doJary d-Q alkoxycarbonylamino, (C CeJalkylamino, ((CrC 6 )alkyl) 2 amino, (C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino(C 1 -C 6 )alkyl, hydroxy, (d-C 6 )alkoxy, carboxy, carboxy(d-C 6 )alkyl, (C C 6 )alkoxycarbonyl, (C C 6 )alkoxycarbonyl(d-C 6 )alkyl, (C C 6 )alkoxy-CO-NH-, (C C 6 )alkyl-CO-NH-, cyano, (C 5 -C 9 )heterocycloalkyl, amino-CO-NH-, (d-C 6 )alkylamino-CO-NH-, ((C C 6 )alkyl) 2 amino-CO-NH-, (C 6 -C,o)arylamino-CO-NH-, (C 5 -C 9 )heteroarylamino-CO- NH-, (C 1 -C 6 )alkylamino-CO-NH-(C 1 -C 6 )alkyl, ((C C 6 )alkyl) 2 amino-CO-NH-(C C 6 )alkyl, (C 6 -C 10 )arylamino-CO-NH-(d-C 6 )alkyl, (C 5 -C 9 )heteroarylamino-CO-NH-(d- C 6 )alkyl, (C C 6 )alkylsulfonyl, (CrC 6 )alkylsulfonylamino, (d- C 6 )alkylsulfonylamino(CrC 6 )alkyl, (C 6 -C 10 )arylsulfonyl, (C 6 -C 10 )arylsulfonylamino, (C 6 - C 10 )arylsulfonylamino(CrC 6 )alkyl, (C C 6 )alkylsulfonylamino, (C C 6 )alkylsulfonylamino(C 1 -C 6 )alkyl, (C 5 -C 9 )heteroaryl and (C 2 -C 9 )heterocycloalkyl; R 2 and R 3 are each independently selected from the group consisting of hydrogen, deuterium, amino, halo, hydroxy, nitro, carboxy, (C 2 -C 6 )alkenyl, (C 2 - C 6 )alkynyl, trifluoromethyl, trifluoromethoxy, (d-C 6 )alkyl, (C C 6 )alkoxy, (C 3 - C 10 )cycloalkyl wherein the alkyl, alkoxy or cycloalkyl groups are optionally substittued by one to three groups selected from halo, hydroxy, carboxy, amino (d-C 6 )alkylthio, (d-C 6 )alkylamino, ((C 1 -C 6 )alkyl) 2 amino, (C 5 -C 9 )heteroaryl, (C 2 -C 9 )heterocycloalkyl, (C 3 -C 9 )cycloalkyl or (C 6 -C 10 )aryl; or R 2 and R 3 are each independently (C 3 - C 10 )cycloalkyl, (C 3 -C 10 )cycloalkoxy, (CrC 6 )alkylamino, ((C 1 -C 6 )alkyl) 2 amino, (C 6 - C 10 )arylamino, (C C 6 )alkylthio, (C 6 -C 10 )arylthio, (C C 6 )alkylsulfinyl, (C 6 - C 10 )arylsulfinyl, (C C 6 )alkylsulfonyl, (C 6 -C 10 )arylsulfonyl, (C C 6 )acyl, (C C 6 )alkoxy- CO-NH-, (d-C 6 )alkyamino-CO-, (C 5 -C 9 )heteroaryl, (C 2 -C 9 )heterocycloalkyl or (C 6 - C 10 )aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (d-C 6 )alkyl, (C C 6 )alkyl-CO-NH-, (C C 6 )alkoxy- CO-NH-, (d-C 6 )alkyl-CO-NH-(d-C 6 )alkyl, (C 1 -C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkyl, (C C 6 )alkoxy-CO-NH-(C 1 -C 6 )alkoxy, carboxy, carboxy(d-C 6 )alkyl, carboxy(C C 6 )alkoxy, benzyloxycarbonyl(C C 6 )alkoxy, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkoxy, (C 6 -C 10 )aryl, amino, amino(CrC 6 )alkyl, (C C 6 )alkoxycarbonylamino, (C 6 -Cιo)aryl(d- C 6 )alkoxycarbonylamino, (C 1 -C 6 )alkylamino, ((C C 6 )alkyl) 2 amino, (C C 6 )alkylamino(d-C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino(C 1 -C 6 )alkyl, hydroxy, (C C 6 )alkoxy, carboxy, carboxy(d-C 6 )alkyl, (d-C 6 )alkoxycarbonyl, (C 1 -C 6 )alkoxycarbonyl(C 1 - C 6 )alkyl, (C C 6 )alkoxy-CO-NH-, (d-C 6 )alkyl-CO-NH-, cyano, (C 5 -C 9 )heterocycloalkyl, amino-CO-NH-, (d-C 6 )alkylamino-CO-NH-, ((d-CeJalkyl^amino-CO-NH-, (C 6 - C 10 )arylamino-CO-NH-, (C 5 -C 9 )heteroary)amino-CO-NH-, (C C 6 )alkylamino-CO-NH- (C C 6 )alkyl, ((C 1 -C 6 )alkyl) 2 amino-CO-NH-(C 1 -C 6 )alkyl, (C 6 -C 10 )arylamino-CO-NH-(C 1 - C 6 )alkyl, (C 5 -C 9 )heteroarylamino-CO-NH-(Cι-C 6 )alkyl, (C C 6 )alkylsulfonyl, (C C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylsulfonylamino(C 1 -C 6 )alkyl, (C 6 -C 10 )arylsulfonyl, (C 6 - C 0 )arylsulfonylamino, (C 6 -C 1 o)arylsulfonylamino(C 1 -C 6 )alkyl, (d- C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylsulfonylamino(Cι-C 6 )alkyl, (C 5 -C 9 )heteroaryl or (C 2 - C 9 )heterocycloalkyl; with the proviso that R 5 must be substituted by the group of formula II. 2. A compound according to claim 1 , wherein R 5 is (C 2 - C 9 )heterocycloalkyl optionally substituted by one to three groups selected from deuterium, hydroxy, (C 1 -C 6 )alkyl, halo, (d-C 6 )alkoxy and a group of formula II. 3. A compound according to claim 1 , wherein a is 0; b is 1 ; X is carbonyl; c is 0; d is 0; e is 0; f is 0; and g is 0. 4. A compound according to claim 1 , wherein a is 0; b is 1 ; X is carbonyl; c is 0; d is 1 ; e is 0; f is 0, and g is 0. 5. A compound according to claim 1 , wherein a is 0; b is 1 ; X is carbonyl; c is 1 ; d is 0; e is 0; f is 0; and g is 0. 6. A compound according to claim 1 , wherein a is 0; b is 1; X is - C(=N=cyano)-; c is 1 ; d is 0; e is 0; f is 0; and g is 0. 7. A compound according to claim 1 , wherein a is 0; b is 0; c is 0; d is 0; e is 0; f is 0; g is 1 ; and Z is -C(O)-O-. 8. A compound according to claim 1 , wherein a is 0; b is 1 ; X is S(O) n ; n is 2; c is 0; d is 0; e is 0; f is 0; and g is 0. 9. A compound according to claim 1 , wherein a is 0; b is 1 ; X is S(O) n ; n is 2; c is 0; d is 2; e is 0; f is 1 ; g is 1 ; and Z is carbonyl. 10. A compound according to claim 1 , wherein a is 0; b is 1 ; X is S(O) n ; n is 2; c is 0; d is 2; e is 0; f is 1 ; and g is 0. 11. A compound according to claim 1 , wherein a is 0; b is 1 ; X is carbonyl; c is 1 ; d is 0; e is 1 ; Y is S(O) n ; n is 2; f is 0; and g is 0. 12. A compound according to claim 1 , wherein a is 0; b is 1; X is S(O) n ; n is 2; c is 1 ; d is 0; e is 0; f is 0; and g is 0. 13. A compound according to claim 1 , wherein a is 1 ; b is 1 ; X is carbonyl; c is 1 ; d is 0; e is 0; f is 0; and g is 0. 14. A compound according to claim 1, wherein a is 0; b is 1; X is S(O) n ; c is 0; d is 1 ; e is 1 ; Y is S(O) n ; n is 2; f is 0; and g is 0. 15. A compound according to claim 1 , wherein a is 0; b is 1 ; X is S(O) n ; c is 0; d is 2, 3 or 4; e is 1 ; Y is S(O) n ; n is 2; f is 1 ; and g is 0. 16. A compound according to claim 1 , wherein a is 0; b is 1 ; X is oxygen; c is 0; d is 2, 3 or 4; e is 1 ; Y is S(O) n ; n is 2; f is 1 ; and g is 0. 17. A compound according to claim 1 , wherein a is 0; b is 1 ; X is oxygen; c is 0; d is 2, 3 or 4; e is 1 ; Y is S(O) n ; n is 2; f is 0; and g is 0. 18. A compound according to claim 1 , wherein a is 0; b is 1 ; X is carbonyl; c is 1; d is 2, 3 or 4; e is 1; Y is S(O) n ; f is 0; and g is 0. 19. A compound according to claim 1 , wherein a is 0; b is 1 ; X is carbonyl; c is 1 ; d is 2, 3 or 4; e is 1 ; Y is S(O) n ; n is 2; f is 1 ; and g is 0. 20. A compound according to claim 1 , wherein R 12 is (C 6 -C 10 )aryl or (C 2 - C 9 )heteroaryl wherein the aryl or heteroaryl group is optionally substituted by one to four groups consisting of hydrogen, halo, hydroxy, carboxy, trifluormethyl, (d- C 6 )alkyl, (C C 6 )alkoxy, (d-C 6 )alkyl-CO-NH-, amino, amino(d-C 6 )alkyl, (C,- C 6 )alkylamino, ((C-|-C 6 )alkyl) 2 amino, cyano, amino-CO-NH-, (d-C 6 )alkylamino-CO- NH-, ((C C 6 )alkyl) 2 amino-CO-NH-, (C 5 -C 9 )heteroarylamino-CO-NH-, (C C 6 )alkylsulfonyl, (d-C 6 )alkylsulfonylamino, (C 6 -C 10 )arylsulfonylamino, (C C 6 )alkylsulfonylamino, and (d-C 6 )alkoxy-CO-NH-. 21. A compound according to claim 1 , wherein said compound is selected from the group consisting of: 4-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1- ylmethyl}-benzenesulfonamide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-sulfamoyl-phenyl)-amide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-nitro-phenyl)-amide; 1 -{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1 - yl}-2-tetrazol-1 -yl-ethanone; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pipehdine-1- carboxylic acid (4-methylsulfamoyl-phenyl)-amide; (3-Hydroxy-pyrrolidin-1-yl)-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)-amino]-piperidin-1-yl}-methanone; [2-({4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine- 1-carbonyl}-amino)- thiazol-4-yl]-acetic acid; Methyl-(4-methyl-5'-nitro-3,4,5,6-tetrahydro-2H-[1 ,2 , ]bipyridinyl-3-yl)-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-amine; 5-(2-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin- 1 -yl}-2-oxo-ethyl)- thiazolidine-2,4-dione; {4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyhmidin-4-yl)-amino]-piperidin-1-yl}- thiazolidin-3-yl-methanone; Methyl-[4-methyl-1-(5-nitro-thiazol-2-yl)-piperidin-3-yl]-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-amine; [2-({4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine- 1-carbonyl}-amino)- thiazol-4-yl]-acetic acid ethyl ester; • 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pipehdine-1- carboxylic acid (4-methanesulfonyl-phenyl)-amide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid thiazol-2-ylamide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyhmidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-cyano-phenyl)-amide; {4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pipehdin-1-yl}- pyrrolidin-1 -yl-methanone; Furan-2-carboxylic acid (2-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)-amino]-piperidine-1-sulfonyl}-ethyl)-amide; {4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl} (tetrahydro-furan-3-yl)-methanone; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid isoxazol-3-ylamide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (6-cyano-pyridin-3-yl)-amide; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-3,4,5,6- tetrahydro-2H-[1 ,2']bipyridinyl-5'-carbonitrile 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (4-methyl-thiazol-2-yl)-amide; 2-Cyclopropyl-1-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- amino]-piperidin-1 -yl}-ethanone; Cyclopentyl-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]- pipehdin-1 -yl}-Methanone; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (3-methyl-isoxazol-4-yl)-amide; [4-({4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine- 1-carbonyl}-amino)- phenylj-acetic acid; [1-(5-Amino-thiazol-2-yl)-4-methyl-piperidin-3-yl]-methyl-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-amine; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid (3-methyl-isothiazol-5-yl)-amide; 3-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carbonyl}-cyclopentanone; 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1- carboxylic acid benzyl-methyl-amide; and 4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyhmidin-4-yl)-amino]-piperidine-1- carboxylic acid dimethylamide. 22. A pharmaceutical composition for (a) treating or preventing a disorder or condition selected from organ transplant rejection, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases or (b) the inhibition of protein kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising an amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof, effective in such disorders or conditions and a pharmaceutically acceptable carrier. 23. A pharmaceutical composition for (a) treating or preventing a disorder or condition selected from organ transplant rejection, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases or (b) the inhibition of protein kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising an amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof, alone or in combination with one or more additional agents which modulate a mammalian immune system or with antiinflammatory agents, effective in such disorders or conditions and a pharmaceutically acceptable carrier. 24. A method for the inhibition of protein kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising administering to said mammal an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof. 25. A method for treating or preventing a disorder or condition selected from organ transplant rejection, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases in a mammal, including a human, comprising administering to said mammal an amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof, effective in treating such a condition. 26. A method for the inhibition of protein kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising administering to said mammal an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof alone or in combination with one or more additional agents which modulate a mammalian immune system or with antiinflammatory agents. 27. A method for treating or preventing a disorder or condition selected from organ transplant rejection, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases in a mammal, including a human, comprising administering to said mammal an amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof, alone or in combination with one or more additional agents which modulate a mammalian immune system or with anti-inflammatory agents, effective in treating such a condition.

Inventors: BLUMENKOPF TODD ANDREW, FLANAGAN MARK EDWARD, MUNCHHOF MICHAEL JOHN, BLUMENKOPF, TODD, ANDREW, FLANAGAN, MARK, EDWARD, MUNCHHOF, MICHAEL, JOHN
Applicants: BLUMENKOPF TODD ANDREW, FLANAGAN MARK EDWARD, MUNCHHOF MICHAEL JOHN, PFIZER PROD INC, BLUMENKOPF, TODD, ANDREW, FLANAGAN, MARK, EDWARD, MUNCHHOF, MICHAEL, JOHN, PFIZER PRODUCTS INC.
Application year: 2001
Main classification: C07D487
IPC codes: A61K31, A61K45, A61P1, A61P3, A61P5, A61P7, A61P9, A61P11, A61P17, A61P19, A61P21, A61P25, A61P29, A61P35, A61P37, A61P43, C07D207, C07D237, C07D487