INDAZOLES SUBSTITUTED WITH 1,1-DIOXOISOTHIAZOLIDINE USEFUL AS INHIBITORS OF CELL PROLIFERATION

Abstract: The present invention relates to an indazole derivative, pharmaceutically acceptable salt, solvated product and isomer thereof substituted with 1,1-dioxoisothiazolidine which are useful as inhibitors for Cyclin Dependent Kinase(CDK). The present invention also relates to an agent for inhibiting and treating diseases involving cell proliferation, e.g., cancer, inflammation, restenosis, angiogenesis, etc. which comprises the indazole derivative as an active ingredient together with a pharmaceutically acceptable carrier.

Description: INDAZOLES SUBSTITUTED WITH 1,1-DIOXOISOTHIAZOLLDLNE USEFUL AS INHIBITORS OF CELL PROLIFERATION TECHNICAL FIELD The present invention relates to a novel indazole derivative represented by the following formula (1): in which n represents 0, 1, 2 or 3, X represents oxygen, sulfur or nitrogen atom, R 1 and R 2 each independently represent hydrogen, amino, hydroxy, lower alkyl or cycloalkyl, or together form cycloalkyl, R 3 represents hydrogen; lower alkyl; phenyl, benzyl or naphthyl which may be unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, halogen, nitro, amide, ester, carboxy, cyano, amidinyl, -O-R 5 , - NR 6 R 7 , phenyl, alkylsulfanyl, R 8 -SO 2 -, lower alkyl, lower alkyl substituted with R 9 , pyridinyl, piperidinyl, morpholinyl, piperazinyl, thienyl and furyl; aromatic and bicyclic aromatic compounds bearing at least one heteroatom selected from nitrogen, oxygen or sulfur atom; C 3 . 7 -cycloalkyl bearing at least one heteroatom selected from nitrogen, oxygen or sulfur atom; piperazinyl, imidazolyl. morpholinyl or piperidinyl which may be unsubstituted or substituted with one or two substituents selected from the group consisting of lower alkyl, phenyl, phenyl substituted with halogen, phenyl substituted with alkoxy, phenyl substituted with alkylcarbonyl, biphenyl and naphthyl; thiazole which may be unsubstituted or substituted with amino, mono- or di- lower alkylamino, alkylcarbonylamino, benzylamino, benzyloxycarbonylamino, benzyloxybenzylamino or alkoxycarbonylamino; benzodioxol; isoquinoline; indolyl; or benzimidazole wherein R 5 represents phenyl, benzyl, lower alkyl, alkoxyalkyl, alkoxyalkoxylalkyl, alkoxyalkoxyalkoxyalkyl, aminoalkyl or mono- or di-alkylaminoalkyl, R 6 and R 7 are identifical or different from each other and represent hydrogen, lower alkyl, oxygen or benzyl, or joined to form a ring, and R 8 and R 9 represent each independently lower alkyl, amino, morpholinyl, piperazinyl, N-alkylpiperazinyl or imidazolyl, and R 4 represents nothing when X is oxygen or sulfur atom, but represents hydroxy or alkoxy when X is nitrogen atom, pharmaceutically acceptable salt, solvated product and isomer thereof which are useful as inhibitors for Cyclin Dependent Kinase(hereinafter, refered to as "CDK"), and method for preparing the same. The present invention also relates to an agent for inhibiting and treating diseases involving cell proliferation such as cancer, inflammation, restenosis and angiogenesis which comprises the compound of formula (1) as an active ingredient together with a pharmaceutically acceptable carrier. BACKGROUND ART Researches on cell division process in molecular level have been extensively performed from the late 1980's through study of division of frog oocytes, analysis several yeast cell growth or characterization of induced mutants by radiation and study of the tumor suppressor Rb. In the 1990's, it is discovered that small molecular cell growth regulator controls cell division process(i.e. growth, differentiation, cytogenesis, aging and apoptosis etc.) through its own regulatory function. These results were very useful for more precise understanding of the pathology of several diseases. A representative example is cancer. In transformation process from normal cells to cancer cells, it was frequently observed that cell growth regulator loses its own function. That is to say, in cancer cells, the cell growth regulator shows an abnormal activity, which is deeply associated with invasion/metastasis which is crucial in the cancerpathology. Particularly, cell cycle deregulation is recognized to be a direct cause of cancer since cancer occurs in experimental animal when overexpression or knock-out of cell growth regulator is induced by using tranformed animal. The cell growth is under positive or negative regulation in the same manner as other biological regulations. The major pathway of cell cycle regulation known up to now is based on CDK activity and, as a result of studies on many cancer cells and carcinogenesis mechanisms, it was confirmed that problems of positive or negative regulation on CDK activity result in carcinogenesis in many cases. That is, cancer may occur when positive or negative regulation and timely regulation which is important for cell growth regulation are disrupted. The representative CDKs of mammals are CDK4(Cyclin dependent kinase 4) and CDK2 which show their activity in Gl-S phase of cell cycle, CDC2(CDK1) which shows its activity in G2-M phase, and so on. It is known that CDK4 and CDK2 activities are regulated by check point of Gl-S cell cycle and CDC2 activity by check point of G2-M. In many cancer cells, abnormalities appear in the regulatory mechanism of CDK4, CDK2 and CDC2(CDK1) and in fact, it was confirmed that induced abnormalities cause cancer in the transformed animal. Therefore, CDK4, CDK2 and CDC2(CDK1) among several kinds of CDKs are suitable as a target of anti-cancer agents. The results of studies on relation between these CDKs and carcinogenesis will be explained in more detail in the following, The relation between the abnormal regulation of CDK4 activity and carcinogenesis is observed in several cancer tissues. The deletion of pl6 and pi 5 genes generating proteins which inhibit CDK4 activity and the overexpression of cyclin DI indispensable for CDK4 activity are observed in several kinds of cancer, which suggests that malignant phenotype may be expressed when CDK4 activity is deregulated. Furthermore, it was reported that ρl6 knocked-out mouse has such a high carcinogenesis rate as p53 knocked- out mouse, which suggests that malfunction of pl6 on CDK4 regulation is a cause of carcinogenesis. From these experimental results, deregulation of CDK4 activity may be a cause of carcinogenesis and play a role in maintenance of phenotype of cancer cell. Therefore, CDK4 inhibitors may have anti-cancer effects. It was reported that overexpression of cyclin E indispensible for CDK2 activity is observed in some breast cancers, deeply associated with metastasis of breast cancer, inhibits cell apoptosis under low serum condition and induces anchorage independent growth, and that hyperproliferation and neoplasia of mammary epithelial cells are observed in transformed animal with overexpressed CDK2 by MMTV promoter, which suggests that CDK2 activity is related with the progress or maintenance of cell transformation and CDK2 inhibitors may also have anti-cancer effects. Furthermore, it is discovered that CDC2(CDK1), CDK3, CDK5, CDK6 and CDK7 play an important role in each phase of cell division. These are classified into CDKs family. In addition to cyclin DI and E, cyclin A, B, C, D2, D3, D4, F and G are also calssified into the same family. On the basis of the above-mentioned research, efficient inhibitors of these CDKs may be useful as anti-cancer agents. Therefore, recently, these inhibitors have been developed. As effective CDK inhibitors developed hitherto, there exists Flavopiridol, compound of the formula (A): [Ref. : EP 0,241,003(1987) and 0,336,061(1990)]. In addition, a purine derivative of the formula (B): has been recently developed[Ref : WO 97/20842]. Recently, a CDKs inhibitor having aminopyridine structure of the formula (C): is disclosed in WO 98/33798. However, the CDK inhibitors developed up to now could not have satisfactory effects. So, the present inventors have made widespread and concentrative researches on CDK inhibitors, particularly indazole-based compounds, and as a result, found that a component of the formula (1) which has a quite different structure from any other known CDK inhibitors inhibits CDKs enzymes effectively and finally, completed the present invention. DISCLOSURE OF THE INVENTION The object of the present invention is to provide a novel indazole derivative of formula (1), a process for preparing the same, and a composition for inhibiting and treating diseases involving cell proliferation such as cancer, inflammation, restenosis and angiogenesis which comprises as an active ingredient the compound of formula (1). In this specification, CDKs include all of CDK2, CDK4, CDC2(CDK1), CDK3, CDK5, CDK6, CDK7 etc., and cyclin includes cyclin DI, E, A, B, C, D2, D3, D4, F and G. DETAD ED DESCRffTION OF THE INVENTION Hereinafter, the present invention is explained in detail. The present invention relates to a novel indazole derivative represented by the following formula (1): in which n represents 0, 1, 2 or 3, X represents oxygen, sulfur or nitrogen atom, R 1 and R 2 each independently represent hydrogen, amino, hydroxy, lower alkyl or cycloalkyl, or together form cycloalkyl, R 3 represents hydrogen; lower alkyl; phenyl, benzyl or naphthyl which may be unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, halogen, nitro, amide, ester, carboxy, cyano, amidinyl, -O-R 5 , -NR 6 R 7 , phenyl, alkylsulfanyl, R 8 -SO 2 -, lower alkyl, lower alkyl substituted with R 9 , pyridinyl, piperidinyl, morpholinyl, piperazinyl, thienyl and furyl; aromatic and bicyclic aromatic compounds bearing at least one heteroatom selected from nitrogen, oxygen or sulfur atom; C 3 . 7 -cycloalkyl bearing at least one heteroatom selected from nitrogen, oxygen or sulfur atom; piperazinyl, imidazolyl, morpholinyl or piperidinyl which may be unsubstituted or substituted with one or two substituents selected from the group consisting of lower alkyl, phenyl, phenyl substituted with halogen, phenyl substituted with alkoxy, phenyl substituted with alkylcarbonyl, biphenyl and naphthyl; thiazole which may be unsubstituted or substituted with amino, mono- or di- lower alkylamino, alkylcarbonylamino, benzylamino, benzyloxycarbonylamino, benzyloxybenzylamino or alkoxycarbonylamino; benzodioxol; isoquinoline; indolyl; or benzimidazole wherein R 5 represents phenyl, benzyl, lower alkyl, alkoxyalkyl, alkoxyalkoxylalkyl, alkoxyalkoxyalkoxyalkyl, aminoalkyl or mono- or di- alkylaminoalkyl, R 6 and R 7 are identifical or different from each other and represent hydrogen, lower alkyl, oxygen or benzyl, or joined to form a ring, and R 8 and R 9 represent each independently lower alkyl, amino, morpholinyl, piperazinyl, N-alkylpiperazinyl or imidazolyl, and R 4 represents nothing when X is oxygen or sulfur atom, but represents hydroxy or alkoxy when X is nitrogen atom, pharmaceutically acceptable salt, solvated product and isomer thereof which have efficacies on inhibiting and treating diseases involving cell proliferation such as cancer, inflammation, restenosis and angiogenesis through a mechanism of inhibiting CDKs activity. Among the indazole derivatives of formula (1) according to the present invention, the preferred compounds include those wherein n represents 1 or 2, X represents oxygen, sulfur or nitrogen atom, R 1 and R 2 each independently represent hydrogen, amino, hydroxy, lower alkyl or cycloalkyl, or together form cycloalkyl, R 3 represents hydrogen; lower alkyl; phenyl which may be unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, halogen, nitro, amide, cyano, amidinyl, -O-R 5 , - R 6 R 7 , phenyl, lower alkylsulfanyl, R 8 - SO 2 -, lower alkyl, lower alkyl substituted with R 9 , pyridiny, piperidinyl, morpholinyl, thienyl and furyl; naphthyl; piperazinyl or imidazolyl which may be unsubstituted or substituted with one or two substituents selected from the group consisting of lower alkyl, phenyl, phenyl substituted with halogen, phenyl substituted with lower alkoxy, phenyl substituted with acetyl, biphenyl and naphthyl; morpholinyl; piperidinyl; thiazole which may be unsubstituted or substituted with amino, mono- or di- lower alkylamino, acetylamino, benzylamino, benzyloxyamino, benzyloxybenzylamino or lower alkoxycarbonylamino; benzodioxol; 3,4-dihydroisoquinoline; or benzimidazole wherein R 5 represents phenyl, benzyl, lower alkyl, lower alkoxyalkyl, polyethyleneglycolyl, aminoalkyl or mono- or di- lower alkylaminoalkyl, R 6 and R 7 are identifical or different from each other and represent hydrogen, lower alkyl, oxygen or benzyl, or joined to form a ring, and R 8 and R 9 each independently represent lower alkyl, amino, morpholinyl, piperazinyl, N-alkylpiperazinyl or imidazolyl, and R 4 represents nothing when X is oxygen or sulfur atom, but represents hydroxy or alkoxy when X is nitrogen atom. The term "lower alkyl" in the substituents of the compound of formula (1) refers to a linear or branched saturated radical of from 1 to 6 C atoms such as methyl, ethyl, isopropyl, isobutyl and t-butyl. The term "lower alkoxy" refers to a linear or branched radical of from 1 to 6 C atoms such as methoxy, ethoxy, isopropoxy, isobutoxy and t- butoxy. Since the compounds of formula (1) according to the present invention may have asymmetric carbon centers, they can be present in the form of enantiomer or diastereomer, and mixtures thereof including racemate. Therefore, the present invention also includes all these isomers and their mixtures. The compound of formula (1) according to the present invention may also form a pharmaceutically acceptable salt. Such a salt includes non-toxic acid addition salt containing pharmaceutical acceptable anion, for example a salt with inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrobromic acid, hydroiodic acid, etc., a salt with organic carboxylic acids such as tartaric acid, formic acid, citric acid, acetic acid, trichloroacetic acid, trifluoroacetic acid, capric acid, isobutanoic acid, oxalic acid, malonic acid, succinic acid, phthalic acid, gluconic acid, benzoic acid, lactic acid, fumaric acid, maleic acid, etc., or a salt with sulfonic acids such as methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, naphthalenesulfomc acid, etc. The representative examples of the compound of formula (1) according to the present invention are 1. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-phenylacetamide, 2. 2-(3-chlorophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]- acetamide, 3. 2-[4-(benzyloxy)phenyl]-N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]acetamide, 4. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-hydroxy-ρhen- yl)acetamide, 5. 2-[4-(dibenzylamino)phenyl]-N-[5-(l , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-ind- azol-3 -yl] acetamide, 6. N-[5-(l , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]-2-[4-(methylamino)- phenyl] acetamide, 7. 2-(4-aminophenyl)-N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]- acetamide, 8. 2-(4-chlorophenyl)-N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]- acetamide, 9. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-fluorophenyl)- acetamide, 10. 2-[l, l'-biρhenyl]-4-yl-N-[5-(l, 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3- yl] acetamide, 11. 2-(3 -bromoρhenyl)-N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl] - acetamide, 12. 2-(4-bromoρhenyl)-N-[5-(l, 1 -dioxo- lλ 5 -isothiazolidin-2-yl)-lH-indazol-3-yl]- acetamide, 13. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]-2-phenylethanethio- amide, 14. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-N'-hydroxy-2-phen- ylethaneimidoamide, 15. 2-(l,3-benzodioxol-5-yl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3 -yl] acetamide, 16. N- [5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl lH-indazol-3 -yl]-2-( 1 -naphthyl)acet- amide. 17. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(2-naphthyl)acet- amide, 18. N-[5-( 1, 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-(3 -nitrophenyl)ac- etamide, 19. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl] acetamide, 20. N-[5-(l,l-dioxo-lλ 5 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(methylsulfan- yl)phenyl]acetamide, 21. 2-(3 -aminophenyl)-N-[5-(l, 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]- acetamide, 22. N- [5 -( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl] ethanethioamide, 23. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-N'-hydroxyethane- imidoamide, 24. 2-(3,4-dichlorophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3- yl] acetamide, 25. N-[5 -(1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-3 -phenylpropanami- de, 26. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-isopropylphen- yl)acetamide, 27. N- [5 -( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- 1 H-indazol-3 -yl] -2-(3 -methylpheny 1)- acetamide, 28. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-methylphenyl)- acetamide, 29. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(methylsulfon- y l)phenyl] acetamide, 30. N- [5-(l , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-(4-methyl- 1 -pipe- razinyl) acetamide, 31. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-morpholinyl)- acetamide, 32. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-mdazol-3-yl]-2-(l-piperidinyl)- acetamide, 33. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-pyridinyl)- phenyl] acetamide, 34. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(l-piperidin- yl)phenyι]acetamide. 35. N- [5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-[4-( 1 -morpholin- yl)-phenyl] acetamide, 36. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(3-thienyl)ph- enyl] acetamide, 37. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-morpholin- ylsulfonyl)phenyl]acetamide, 38. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-methoxyphen- yl)acetamide, 39. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(2-furyl)phen- yl] acetamide, 40, N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-4-[(4-methyl-l- ρiperazinyl)sulfonyl]phenylacetamide, 41. 2-(lH-benzimidazol-l-yl)-N-[5-(l, 1 -dioxo- lλ 6 -isothiazolidin-2-yl)-lH-indaz- ol-3-yl]acetamide, 42. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-(4-ethoxyphenyl)- acetamide, 43. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-morpholin- ylmethyl)phenyl]acetamide, 44. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-4-[(4-methyl-l- piperazinyl)methyl]phenylacetamide, 45. N-[5-(l , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-(4-nitrophenyl)- acetamide, 46. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(lH-imidazol- 1 -ylmethyl)phenyl] acetamide, 47. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-phenyl-lH-im- idazol- 1 -yl)acetamide, 48. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-(4-phenyl- 1 -piperazinyl) acetamide, 49. 2-[3 ,4-dihydro-2(lH)-isoquinolinyl]-N-[5-(l , 1-dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]acetamide, 50. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-chloroρhen- yl)-l -piperazinyl] acetamide, 51. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-methoxyph- enyl)- 1 -piperazinyljacetamide, 52. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(2-ethoxyphen- yl)- 1 -piperazinyl] acetamide, 53. 2- [4-(4-acetylphenyl)- 1 -piρerazinyl]-N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- 1 H-indazol-3 -yl] acetamide, 54. N-[5-(l,l-dioxo-lλ δ -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-phenoxyphen- yl)acetamide, 55. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-l-phenylcyclopen- tanecarboxamide, 56. 2-cyclopentyl-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-ph- enylacetamide, 57. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-phenylbutanami- de, 58. t-butyl 4-(2-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]amino-2- oxoethyl)- 1 ,3 -thiazol-2-ylcarbamate, 59. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-4-[2-(2-ethoxy- ethoxy)ethoxy]phenylacetamide, 60. 2-(2-amino-l,3-thiazol-4-yl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-in- dazol-3-yl]acetamide, 61. 2-[4-(4-bromophenyl)- lH-imidazol- 1 -yl]-N-[5-(l, 1-dioxo- 1 λ 6 -isothiazolidin- 2-yl)-lH-indazol-3-yl]acetamide, 62. N-[5-(l,l-dioxo-lλ δ -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(2-naphthyl)- lH-imidazol-l-yl]acetamide, 63. 2-(4-[l, 1 '-biphenyl]-4-yl- lH-imidazol- 1 -yl)-N-[5-(l , 1-dioxo-l λ 6 -isothiazolid- in-2-yl)- 1 H-indazol-3 -yl] acetamide, 64. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[2-(ethylamino)- l,3-thiazol-4-yl]acetamide, 65. 2-[2-(diethylamino)-l,3-thiazol-4-yl]-N-[5-(l 5 l-dioxo-lλ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]acetamide, 66. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-2-[2-(2-meth- oxyethoxy)ethoxy]ethoxyphenyl)acetamide, 67. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-ethoxy-3-nitro- phenyl)acetamide, 68. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(2-methylρhenyl)- acetamide, 69. N-[5 -( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-[3 -(ethylamino)- pheny 1] acetamide, 70. 2-[3-(diethylamino)phenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-inda- zol-3-yl]acetamide, 71. 2-(3,5-dimethoxyphenyl)-N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3 -yl] acetamide, 72. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(ethylamino)- pheny 1] acetamide, 73. 2-[4-(diethylamino)phenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-inda- zol-3 -yl] acetamide, 74. 2-(3-chloro-4-ethoxyphenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-ind- azol-3 -yl] acetamide, 75. 2-[4-(2-aminoethoxy)phenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-ind- azol-3-yl]acetamide, 76. 2-[2-(acetylamino)-l,3-thiazol-4-yl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]acetamide, 77. 2-(2-[4-(benzyloxy)benzyl]amino-l,3-thiazol-4-yl)-N-[5-(l,l-dioxo-lλ 6 -isothi- azolidin-2-yl)-lH-indazol-3-yl]acetamide, 78. N-[5 -(1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-(3 -ethoxyphenyl)- acetamide, 79. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-ethoxy-3-(4- morpholinylsulfonyl)phenyl]acetamide, 80. 2-[3-(aminosulfonyl)-4-ethoxyphenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2- yl)- lH-indazol-3-yl]acetamide, 81. N-[5 -( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-4-ethoxy-3 -[(4- methyl- 1 -piperazinyl)sulfonyl]phenylacetamide, and 82. 2-[4-(2-aminoethoxy)phenyl]-N-[5-(l,l-dioxo-lλ 5 -isothiazolidin-2-yl)-lH- indazol-3 -yl] acetamide. The processes for preparing the compound of formula (1) as defined above are depicted in the following Scheme (1): [Scheme 1] wherein R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl. That is, as depicted in the above Scheme (1), an amidoxime of the following formula (2): is prepared by reacting anthranilonitrile with hydroxylamine, and the amidoxime thus prepared is then reacted with ester to produce a 3-aminoindazole of the following formula (3): wherein R 1 , R 2 and R 3 are as previously described. A 1 -position of 3-aminoindazole is protected by t-butylcarbamate to produce a compound of the following formula (4): wherein R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl, and then nitro group at C-5 is reduced to produce an amine of the following formula (5): wherein R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl. A sulfonamide of the following formula (6): wherein R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl, which is obtained by reacting the compound of formula (5) with sulfonyl chloride is cyclized through intramolecular ring-closure to synthesize a dioxoisothiazolidine of the following formula (7): wherein R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl. Finally, the compound of formula (7) is deprotected to give the compound of formula (1). A compound of formula (1) wherein X is oxygen atom is reacted with Lawesson's reagent (2,4-bis-(4-methoxyphenyl-l,3-dithia-2,4-diphosphethane-2,4- disulfide) to produce a compound of formula (1) wherein X is sulfur atom, or the compound of formula (1) wherein X is sulfur atom is reacted with a compound of the following formula (8): R 4 -NH 2 (8) wherein R 4 is as previously described, to produce a compound of formula (1) wherein X is nitrogen atom: The indazole derivative of formula (1) according to the present invention may also be synthesized through amidization followed by deprotection of an indazole intermediate of the following formula (9): wherein Cbz represents benzyloxycarbonyl. Specifically, the indazole intermediate of formula (9) is reacted with an acyl halide of the following formula (10): wherein R 1 , R 2 , R 3 and n are as previously described in the formula (1), and X' represents halogen, for example, CI, or Br., and then subjected to deprotection to give the compound of formula (1), which will be described in the following Example 2. Meanwhile, the indazole derivative of formula (9) is prepared by using anthranilonitrile as a starting material, as depicted in the following Scheme (2): wherein R 1 , R 2 , R 3 and n are as previously described, Boc represents t- butoxycarbonyl, and Cbz represents benzyloxycarbonyl. Specifically, as depicted in the Scheme (2) above, the indazole derivative of formula (9) is prepared by reacting amidoxime of anthranilonitrile with ethyl phenylacetate in accordance with the above Scheme (1) to produce an indazole derivative of the following formula (11): , which corresponds to the compound of formula (1), protecting a nitrogen at 1-position of the indazole derivative by benzylcarbamate to produce a compound of the following formula (12): wherein Cbz represents benzyloxycarbonyl, cleaving an amide bond in the compound of formula (12) using di-t-butylcarbonate to produce a compound of the following formula (13): wherein Boc represents t-butoxycarbonyl, and Cbz represents benzyloxycarbonyl. , and removing t-butoxycarbonyl groups. However, the process for preparing the compounds according to the present invention has been described in detail for the purpose of illustration, but should not be interpreted to limit the invention. The compounds of the present invention can easily be prepared by conventional methods of organic synthesis described in the prior art or combinations thereof, and such combinations are well known to those skilled in the art. The compound of the formula (1) according to the present invention has an inhibitory activity against CDK, and thus may be put to a good use as an agent for inhibiting and treating diseases involving cell proliferation such as cancer, inflammation, restenosis and angiogenesis. Accordingly, another object of the present invention is to provide a composition for inhibiting and treating diseases involving cell proliferation such as cancer, inflammation, restenosis and angiogenesis which comprises the compound of formula (1), pharmaceutically acceptable salt, solvated product or isomer thereof as an active ingredient together with a pharmaceutically acceptable carrier. When the compound of the present invention is administered for clinical purpose, it is preferably administered in an amount ranging from 1.0 to 50mg/kg of body weight a day. The total daily dosage may be administered in one time or over several times. However, the specific dosage for a specific patient can be varied according to the specific compound used, body weight of the subject patient, sex, hygienic condition, diet, time or method of administration, excretion rate, mixing ratio of the medicine, severity of the disease to be treated, etc. The compound of the present invention may be administered in the form of injections or oral preparations. Injections such as sterilized aqueous or oily suspension for injection may be prepared by using suitable dispersing agent, sufactant or suspension agent according to the known method. As solvents to be used for preparing injections, water, Ringer's fluid and isotonic NaCl solution can be mentioned, and sterilized fixing oil is also used as the solvent or suspension medium. Any non-stimulative fixing oil including mono- or di- glyceride can be used for this purpose, and also fatty acid such as oleic acid can be used for injection formulation. As the solid preparation for oral administration, capsules, tablets, pills, powders and granules, preferably capsules and tablets can be mentioned. It is desirable for tablets and pills to be formulated into enteric-coated preparation. Solid preparations may be prepared by mixing the active compound of formula (1) according to the present invention with at least one carrier selected from the group consisting of inert diluents(e.g. sucrose, lactose, starch, etc.), lubricants(e.g. magnesium stearate), disintegrants, and binders. When it is intended to produce the desired anti-cancer effects by administering clinically the compound of the invention, the active compound of the formula (1) can be administered together with at least one agent selected from the known anti-cancer agents. In this manner, as anti-cancer agents to be administered with the compound of the invention, 5-fluorouracil, cisplatin, doxorubicin, taxol, gemcitabine, etc. can be mentioned. However, the preparations containing the compound according to the invention intended for anti-cancer effect are not limited to those described above, and any preparations useful for treating and inhibiting cancers can be included. The present invention is more specifically explained by way of the following prepartions and examples. However, it should be understood that the present invention is not limited to these examples in any manner. Preparation 1. Synthesis of t-butyl 5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-3- [(2-phenylacetyl)amino]-lH-indazol-l-carboxylate 1-1) Synthesis of 2-amino-N-hydroxy-5-nitrobenzenecarboxyimidoamide 27.8g(400mmol) of hydroxylamine hydrochloride and 33.6g(400mmol) of sodium bicarbonate were dissolved in 140ml of water, and then a solution of 33.6g(200mmol) of anthranilonitrile in 520ml of ethanol was added thereto. The mixture was heated under reflux for 12 hours, and then cooled to room temperature. The resulting precipitate was filtered and washed with water and diethyl ether to give 37.2g of the title compound in a yield of 95%. Η NMR (DMSO-d 6 , ppm): 6 6.02(2H, s), 7.78(1H, d), 7.80(2H, s), 7.92(1H, dd), 8.35(1H, d), 9.98(1H, s) FAB MS(m/e) = 197[M+1] 1-2) Synthesis of N-(5~nitro-lH-indazol-3-yl)-2-phenylacetamide 29.4g(150mmol) of the compound obtained in Preparation 1-1) was dissolved in 500ml of tetrahydrofuran, and 9.0g(60%, 225mmol) of sodium hydride was added thereto. The mixture was stirred at room temperature for 30 minutes. 36.9g(225mmol) of ethyl phenylacetate was added thereto, the mixture was stirred for one hour, and then 200ml of N,N-dimethylformamide was added thereto. The mixture was further stirred under slight heating for 4 hours. The solvent was removed under reduced pressure, and the residue was then treated with ethyl acetate and water. The resulting precipitate was filtered and washed with water and diethyl lether to give 20.3g of the title compound in a yield of 48%. Η NMR (DMSO-d 6 , ppm): δ 3.79(2H, s), 7.28(1H, t), 7.30-7.43(4H, m), 7.60(1H, d), 8.12(1H, dd), 9.00(1H, s) FAB MS(m/e) = 283 [M+l] 1-3) Synthesis of t-butyl 5-nitro-3-[(2-phenylacetyl)amino]-lH-indazol-l- car boxy late 8,0g(28mmol) of the compound obtained in Preparation 1-2) was dissolved in 130 mi of tetrahydrofuran, and 3.2g(80mmol) of sodium hydroxide in 20ml of water and 7.1g(33mmol) of di-t-butylcarbonate were added thereto. The mixture was stirred for one hour. After removal of solvents under reduced pressure, the residue was subjected to recrystalization using ethyl acetate and hexane to give the title compound quantatively. Η N-VfR(CDCl 3 , ppm): δ 1.69(9H, s), 3.65(2H, s), 7.24-7.30(5H, m), 7.68(1H, dd), 7.91(1H, s), 8.00(1H, d), 8.73(1H, s) 1-4) Synthesis of t-butyl 5-amino-3-[(2-phenylacetyl)amino]-lH-indazoI-l- carboxylate llg(28mmol) of the compound obtained in Preparation 1-3) was dissolved in methanol, and palladium-adsorbed activated carbon(10%) was added thereto. The mixture was stirred under hydrogen atmosphere for 2 hours. The resulting suspension was filtered through celite, and then the filtrate was concentrated to give the title compound quantatively. Η NMR (CDC1 3 , ppm): δ 1.68(9H, s), 3.68(2H, s), 7.25-7.31(5H, m), 7.45(111 dd), 7.71(1H, s), 7.94(1H, d), 8.64(1H, s) 1-5) Synthesis of t-butyl 5-[[(3~chloropropyI)sulfonyl]amiπo]-3-[(2-phenyl- acetyl)amino]-lH-indazoI-l-carboxylate 6.3g(17mmol) of the compound obtained in Preparation 1-4) was dissolved in 120 ml of dichloromethane, and 13ml(170mmol) of pyridine and 27ml(22mmol) of 3- chloropropanesulfonyl chloride were added thereto. The mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography(eluent: n-hexane/ethylacetate = 1/1 (v/v)) to give the title compound quantatively. Η NMR (CD 3 OD, ppm): δ 1.69(9H, s), 2.20(2H, m), 3.17(2H, t), 3.65(4H, m), 7.29(5H, m). 7.30(1H, m), 7.40(1H, d), 7.60(1H, s) ESI MS(m/e) = 507 [M+l] 1-6) Synthesis of t-butyl 5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yl)-3-[(2-phenyl- acetyI)amino]-lH-indazol-l-carboxylate 8.6g(17mmol) of the compound obtained in Preparation 1-5) was dissolved in 150 mi of N,N-dimethylformamide, and 1.43g(34mmol) of sodium hydride was added thereto. The mixture was stirred for 30 minutes. The solvent was removed under reduced pressure. The residue was extracted with ethyl acetate, and then the extracted ethyl acetate solution was washed with water three times. The solvent was under reduced pressure, and then the residue was purified by silica gel column chromatography(eluent: n- hexane/ethylacetate = l/2(v/v)) to give 8.0g of the title compound quantatively. Η NMR (CDCI 3 , ppm): δ 1.70(9H, s), 2.50(2H, m), 3.28(2H, t), 3.80(4H. m), 7.30(5H, m), 7.68(1H, m), 7.91(1H, s), 8.00(1H, d), 8.73(1H, s) ESI MS(m/e) = 471 [M+l] Example 1. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yl)-lH-indazol-3- yl]-2-phenylacetamide(l) 5.2g(llmmol) of the compound obtained in Preparation 1-6) was added to ethyl acetate which was saturated with hydrogen chloride, and the mixture was stirred for 6 hours. The solvent was removed under reduced pressure to give the title compound quantatively. Η NMR (DMSO-d 6 , ppm): δ 2.39(2H, m), 3.46(2H, t), 3.69(2H, t), 3.74(2H, s), 7.26(1H, t), 7.34(3H, t), 7.39(2H, d), 7.46(1H, d), 7.58(1H, s), 10.69(1H, s) ESI MS(m/e) = 371 [M+l] Preparation 2. Synthesis of benzyl 3-amino-5-(l,l-dioxo-lλ 6 -isothiazoIidin-2- yl)-lH-indazol-l-carboxylate(indazole intermediate of formula (9)) 2-1) Synthesis of benzyl 5-(l,l-dioxo-lλ 6 -isothiazohdin-2-yl)-3-[(2-phenyl- acetyI)amino]-lH-indazol-l-carboxylate After 4.1g(llmmol) of the compound obtained in Example 1 was dissolved in 150 mi of dichloromethane, 10ml(7.9mmol) of triethylamine and 2.25ml(17mmol) of benzyl chloroformate were added. The mixture was stirred for 2 hours. After removal of solvent under reduced pressure, the residue was purified by silica gel column chromatography(eluent: n-hexane/ethylacetate = 2/1 (v/v)) to give 5.2g of the title compound in a yield of 94%. Η NMR (DMSO-d 6 , ppm): δ 2.34(2H, m), 3.52(2H, t), 3.74(2H, t), 3.78(2H, s), 5.48(2H, s), 7.25(1H, m), 7.36(4H, m), 7.44(3H, m), 7.53(2H, d), 7.58(1H, dd), 7.82(1H, s), 8.12(1H, d) ESI MS(m/e) = 505 [M+l] 2-2) Synthesis of benzyl 3-[bis(t-butoxycarbonyl)amino]-5-(l,l-dioxo-lλ 6 -iso- thiazolidin-2-yl)-lH-indazol-l-carboxylate After 5.2g(llmmol) of the compound obtained in Preparation 2-1) was dissolved in 100ml of dichloromethane, 1.36g(llmmol) of N,N-dimethylaminopyridine, 1.55ml (llmmol) of triethylamine and 4.85g(22mmol) of di-t-butylcarbonate were added. The mixture was stirred for 30 minutes. After removal of solvent under reduced pressure, the residue was purified by silica gel column chromatography(eluent: n-hexane/ethylacetate = l/2(v/v)) to give 6.4g of the title compound quantatively. Η NMR (CD 3 OD, ppm): δ 1.36(9H, s), 1.44(9H, s), 2.51(2H, m), 3.45(2H, t), 3.83(2H, t), 5.53(2H, s), 7.34(3H, m), 7.48(1H, d), 7.54(2H, d), 7.56(1H, dd), 8.15(1H, dd) ESI MS(m/e) = 587 [M+l] 2-3) Synthesis of benzyl 3-amino-5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yI)-lH- indazol-1-carboxylate 6.4g(llmmol) of the compound obtained in Preparation 2-2) was added to ethyl acetate which was saturated with hydrogen chloride, and the mixture was stirred for 3 hours. The mixture was neutralized with aqueous IN sodium hydroxide solution, and the precipitate thus obtained was filtered under reduced pressure to give 2g of the title compound in a yield of 47%. Η NMR (DMSO-d 6 , ppm): δ 2.45(2H, m), 3.53(2H, t), 3.77(2H, t), 5.38(2H, s), 6.42(2H, s), 7.37(1H, m), 7.42(2H, m), 7.49(3H, m), 7.71(1H, d), 7.98(1H, d) ESI MS(m/e) = 505 [M+l] Example 2. Synthesis of 2-(3-chIorophenyl)-N-[5-(l,l-dioxo-lλ d -isothiazolidin- 2-yl)-lH-indazol-3-yl]acetamide(2) 50mg(0.13mmol) of the compound obtained in Preparation 2 was added to 10ml of tetrahydrofuran, and 3.7mg(0.2mmol) of 3-chlorophenylacetyl chloride was added. The mixture was heated under reflux for 2 hours. After the mixture was cooled to room temperature, 2ml of aqueous 2N sodium hydroxide solution was added. The mixture was stirred for 2 hours. The resultant was extracted with ethyl acetate, and then the extracted ethyl acetate solution was washed with water three times. After removal of solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluent: n- hexane/ethylacetate = l/4(v/v)) to give 21mg of the title compound in a yield of 40%. Η NMR (CD 3 OD, ppm): δ 2.49(2H, m), 3.41(2H, t), 3.77(2H, t), 3.79(2H, s), 7.28(1H, m). 7.34(2H, m), 7.45(3H, m), 7.60(1H, s) ESI MS(m/e) == 405 [M+l] Example 3. Synthesis of 2-[4-(benzyloxy)phenyl]-N-[5~(l,l-dioxo-lλ 6 -isothia- zolidin-2-yl)- lH-indazol-3-yl] acetamide(3) The title compound was obtained in a yield of 42% according to the same procedure as Example 2, except that 4-benzyloxyphenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (CD 3 OD, ppm): δ 2.48(2H, m), 3.87(2H, t), 3.71(2H, s), 3.75(2H, t), 5.05(2H, s), 6.95(2H, d), 7.32(5H, m), 7.42(4H, m), 7.59(1H, s) API MS(m/e) = 477 [M+l] Example 4. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2~yl)-lH-indazoI-3~ yl]-2-(4-hydroxyphenyl)acetamide(4) The title compound was obtained in a yield of 35% according to the same procedure as Preparation 1-4), except that the compound obtained in Example 3 was used instead of the compound obtained in Preparation 1-3). Η NMR (CD 3 OD, ppm): δ 2.49(2H, m), 3.41(2H, t), 3.68(2H, s), 3.75(2H, t), 6.77(2H, d), 7.24(2H, d), 7.44(2H, m), 7.53(1H, s) ESI MS(m/e) = 387 [M+l] Example 5. Synthesis of 2-[4-(dibenzyIamino)phenyI]-N-[5-(l,l-dioxo-lλ 6 -iso- thiazoIidin-2-yI)-lH-indazoI-3-yI]acetamide(5) The title compound was obtained in a yield of 55% according to the same procedure as Example 2, except that 4-(N,N-dibenzylamino)phenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (CD 3 OD. ppm): δ 2.45(2H, m), 3.37(2H, t), 3.62(2H, s), 3.72(2H, t), 4.62(4H, s), 7.18(4H, m), 7.23(4H, m), 7.27(4H, m), 7.43(2H, m), 7.56(1H, s) ESI MS(m/e) = 566 [M+l] Example 6. Synthesis of N-[5-(l,l-dioxo~lλ 6 -isothiazoIidin-2-yl)-lH-indazoI-3- yI]-2-[4-(methylamino)phenyl]acetamide(6) The procedure was carried out according to the same procedure as Preparation 1-4), except that the compound obtained in Example 5 was used instead of the compound obtained in Preparation 1-3). Then, the residue was purified by silica gel column chromatography(eluent: n-hexane/ethylacetate = l/3(v/v)) to give the title compound in a yield of 10%. Η NMR (CD 3 OD, ppm): δ 2.51(2H, m), 2.76(3H. s), 3.41(2H, t), 3.64(2H, s), 3.76(2H, t), 6.63(2H, d), 7.19(2H, d), 7.43(2H, m), 7.55(1H, s) ESI MS(m e) = 400 [M+l] . Example 7. Synthesis of 2-(4-aminophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin- 2-yl)-lH-indazol-3-yI]acetamide(7) The title compound was obtained in a yield of 20% according to the same procedure as Example 6. Η NMR (CD 3 OD, ppm): δ 2.51(2H, m), 3.43(2H, t), 3.65(2H, s), 3.76(2H, t), 6.72(2H, d), 7.17(2H. d), 7.46(2H, br s), 7.52(1H, br s) ESIMS(m/e) = 386 [M+l] Example 8. Synthesis of 2-(4-chIorophenyI)-N-[5-(l,l-dioxo-lλ δ -isothiazoIidin- 2-yl)-lH-indazol-3-yI]acetamide(8) The title compound was obtained in a yield of 60% according to the same procedure as Example 2, except that 4-chlorophenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (CD 3 OD, ppm): δ 2.47(2H, m), 3.40(2H, t), 3.73(2H, t), 3.77(2H, s), 7.33(2H, d), 7.38(2H, d), 7.43(2H, s), 7.56(1H, s) ESI MS(m/e) = 405 [M+l] Example 9. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3- yl]-2-(4-fluorophenyl)acetamide(9) The title compound was obtained in a yield of 60% according to the same procedure as Example 2, except that 4-fluorophenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (CD 3 OD + CDCI 3 , ppm): δ 2.18(2H, m), 3.07(2H, t), 3.45(4H, m), 6.69(2H, m), 6.88(1H, m), 7.07(3H, m), 7.31(1H, s) API MS(m/e) = 389 [M+l] Example 10. Synthesis of 2-[l,l'-biphenyl]-4-yI-N-[5-(l,l-dioxo-lλ 6 -isothia- zolidin-2-yl)-lH-indazol-3-yI]acetamide(10) The title compound was obtained in a yield of 40% according to the same procedure as Example 2, except that l.l'-biphenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. 'H NMR (CD 3 OD, ppm): δ 2.45(2H, m), 3.38(2H, t), 3.73(2H, t), 3.82(2H, V), 7.30(1H, t), 7.41(4H, m), 7.48(2H, d), 7.58(6H, m) ESI MS(m e) = 447 [M+l] Example 11. Synthesis of 2-(3-bromophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazoli- din-2-yl)-lH-indazol-3-yl]acetamide(ll) The title compound was obtained in a yield of 50% according to the same procedure as Example 2, except that 3-bromophenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. 1 H NMR (CD 3 OD, ppm): δ 2.47(2H, m), 3.40(2H, t), 3.76(4H, m), 7.25(1H, t), 7.35(2H, m), 7.44(2H, m), 7.59(2H, d) ESI MS(m/e) = 450 [M+l] Example 12. Synthesis of 2-(4-bromophenyI)-N-[5-(l,l-dioxo-lλ 6 -isothiazoIi- din-2-yl)-lH-indazol-3-yl]acetamide(12) The title compound was obtained in a yield of 46% according to the same procedure as Example 2, except that 4-bromophenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. 'H NMR (CD 3 OD, ppm): δ 2.48(2H, m), 3.41(2H, t), 3.75(4H, m), 7.33(2H, d), 7.44(2H, s), 7.49(dH, d), 7.56(1H, s) ESI MS(m e) = 450 [M+l] Example 13. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazoI- 3-yl]-2-phenylethanethioamide(13) 100mg(0.3mmol) of the compound obtained in Example 1 was dissolved in tetrahydrofuran, and then 72mg(0.18mmol) of Lawesson's reagent(2,4-bis(4- methoxyphenyl)-l,3-dithia-2,4-diphosphethane-2,4-disulfide) was added thereto. The mixture was heated under reflux for 2 hours. The solvent was removed under reduced pressure, and the residue was then treated with ethyl acetate and hexane. The resulting precipitate was purified by silica gel column chromatography (eluent: methanol/dichloromethane = 5/95(v/v)) to give 80mg of the title compound in a yield of 69%. API MS(nVe) = 387 [M+l] Example 14. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin~2-yI)-lH-indazol- 3-yl]-N'-hydroxy-2-phenylethaneimidoamide(14) 20mg(0.052mmol) of the compound obtained in Example 13 was dissolved in methanol, and then 9mg(0.1mmol) of sodium bicarbonate and 7mg(0.1mmol) of hydroxylamine hydrochloride salt were added thereto. The mixture was heated under reflux for 2 hours. The solvent was removed by evaporation under reduced pressure, and the residue was then purified by silica gel column chromatography (eluent: methanol/dichloromethane = 5/95(v/v)) to give 4mg of the title compound in a yield of 20%. API MS(m/e) = 386 [M+l] Example 15. Synthesis of 2-(l,3-benzodioxol-5-yl)-N-[5-(l,l-dioxo-lλ 6 -isothia- zolidin-2-yI)-lH-indazol-3-yl]acetamide(15) The title compound was obtained in a yield of 36% according to the same procedure as Example 2, except that l,3-benzodioxol-5-yl-acetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (DMSO-d 5 , ppm): δ 2.41(2H, m), 3.42(2H, t), 3.62(2H, s), 3.68(2H, t), 5.95(2H, s), 6.82(2H, s), 6.93(1H, s), 7.34(1H, d), 7.42(1H, d), 7.58QH, s) ESI MS(m/e) = 415 [M+l] Example 16. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(l-naphthyl)acetamide(16) The title compound was obtained in a yield of 60% according to the same procedure as Example 2, except that 1-naphthylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (CD 3 OD + CDC1 3 , ppm): 6 2.47(2H, m), 3.34(2H, t), 3.69(2H, t), 4.24(2H, s), 7.35(1H, d), 7.40(1H, dd), 7.47(2H, m), 7.55(3H, m), 7.80(1H, d), 7.85(1H, d), 8.11(lH, d) ESI MS(m/e) = 421 [M+l] Example 17. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yI)-lH-indazol- 3-yl]-2-(2-naphthyl)acetamide(17) The title compound was obtained in a yield of 57% according to the same procedure as Example 2, except that 2-naphthylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (CD 3 OD + CDCI 3 , ppm): δ 2.43(2H, m), 3.33(2H, t), 3.66(2H, t), 3.92(2H, s), 7.39(4H, m), 7.49(1H, d), 7.57(1H, s), 7.79(3H, m), 7.84(1H, s) ESI MS(m/e) = 421 [M+l] Example 18. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(3-nitrophenyl)acetamide(18) The title compound was obtained in a yield of 30% according to the same procedure as Example 2, except that 3-nitrophenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (CD 3 OD + DMSO-d 6 , ppm): 6 2.42(2H, m), 3.41(2H, t), 3.68(2H, t), 3.91(2H, s), 7.28(1H, d), 7.34(1H, d), 7.42(1H, d), 7.62(1H, s), 7.82(1H, d), 8.12(1H, d), 8.29(1H, s) ESI MS(m/e) = 415 [M+l] Example 19. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]acetamide(19) The title compound was obtained in a yield of 70% according to the same procedure as Example 2, except that acetyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (DMSO-d 6 , ppm): δ 2.44(2H, m), 3.53(2H, t), 3.77(2H, t), 6.48(1H, s), 7.49(1H, dd), 7.72(1H, d), 8.18(1H, d) API MS(m/e) = 295 [M+l] Example 20. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin~2-yl)-lH-indazol- 3-yl]-2-[4-(methylsulfanyI)phenyl]acetamide(20) The title compound was obtained in a yield of 58% according to the same procedure as Example 2, except that 4-(methylsulfanyl)phenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (CD 3 OD + CDCI 3 , ppm): δ 2.44(3H, s), 2.51(2H, m), 3.38(2H, t), 3.72(2H, s), 3.76(2H, t), 7.22(2H, d), 7.32(2H, d), 7.40(2H, m), 7.60(1H, s) API MS(m/e) = 417 [M+l] Example 21. Synthesis of 2-(3-aminophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazoli- din-2-yl)-lH-indazol-3-yl]acetamide(21) The procedure was carried out according to the same procedure as Preparation 1-4), except that the compound obtained in Example 18 was used instead of the compound obtained in Preparation 1-3). Then, the residue was purified by silica gel column chromatography(eluent: n-hexane/ethylacetate = l/4(v/v)) to give the title compound in a yield of 28%. Η NMR (DMSO-d 6 , ppm): δ 2.39(2H, m), 3.47(2H, t), 3.54(2H, s), 3.68(2H, t), 5.11QH, s), 6.44(1H, d), 6.52QH, d), 6.58(1H, s), 6.96(1H, t), 7.34(1H, d), 7.45(1H, d), 7.57(1H, s), 10.53(1H, s) ESI MS(m/e) = 386 [M+l] Example 22. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]ethanethioamide(22) The procedure was carried out according to the same procedure as Example 13, except that the compound obtained in Example 19 was used instead of the compound obtained in Example 1. Then, the residue was purified by silica gel column chromatography(eluent: n-hexane/ethylacetate = l/4(v/v)) to give the title compound in a yield of 34%. ESI MS(m/e) = 311 [M+l] Example 23. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-N'-hydroxyethaneimidoamide(23) 20mg(0.05mmol) of the compound obtained in Example 22 was dissolved in methanol, and then 9mg(0.1mmol) of sodium bicarbonate and 7mg(0.1mmol) of hydroxylamine hydrochloride were added thereto. The mixture was heated under reflux for 2 hours. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography(eluent: methanol/dichloromethane = 5/95(v/v)) to give 4mg of the title compound in a yield of 20%. ESI MS(m/e) = 310 [M+l] Example 24. Synthesis of 2-(3,4-dichlorophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothia- zoIidin-2-yI)-lH-indazoI-3-yI]acetamide(24) The title compound was obtained in a yield of 67% according to the same procedure as Example 2, except that 3,4-dichlorophenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (DMSO-d 6 , ppm): δ 2.39(2H, p), 3.46(2H, t), 3.68(2H, t), 3.78(2H, s), 7.36(2H, m), 7.46QH, d), 7.56QH, m), 7.61(1H, d) , 7.65(1H, s) ESI MS(m/e) = 439 [M+l ] Example 25. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-3-phenylpropanamide(25) The title compound was obtained in a yield of 21% according to the same procedure as Example 2, except that 3-phenylpropanoyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (CD 3 OD + CDCI 3 , ppm): δ 2.50(2H, m), 2.76(2H, t), 3.04(2H, t), 3.40(2H, t), 3.76(2H, t), 7.16(1H, m), 7.26(4H, d), 7.40(2H, m), 7.53(1H, s) ESI MS(m/e) = 385 [M+l] Example 26. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazohdin-2-yl)-lH-indazol- 3-yl]-2-(4-isopropylphenyl)acetamide(26) The title compound was obtained in a yield of 32% according to the same procedure as Example 2, except that 4-isopropylphenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (CD 3 OD + CDCI 3 , ppm): δ 1.20(6H, d), 2.44(2H, m), 2.85(1H, m), 3.41(2H, t), 3.72(4H, m), 7.17(2H, d), 7.30(3H, m), 7.38(1H, dd), 7.64(1H, s) ESI MS(m/e) = 413 [M+l] Example 27. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(3-methylphenyl)acetamide(27) The title compound was obtained in a yield of 67% according to the same procedure as Example 2, except that 3-methylphenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. 'H NMR (CD 3 OD + CDC1 3 + DMSO-d 6 , ppm): δ 2.30(3H, s), 2.40(2H, m), 3.45(2H, t), 3.67(4H, m), 7.20(3H, m), 7.36(2H, m), 7.45(1H, d), 7.58(1H, s) ESI MS(m/e) = 4385 [M+l] Example 28. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yl)-lH-indazol- 3-yl]-2-(4-methylphenyl)acetamide(28) The title compound was obtained in a yield of 69% according to the same procedure as Example 2, except that 4-methylphenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (CD 3 OD + CDCI 3 + DMSO-d 6 , ppm): δ 2.26(3H, s), 2.40(2H, m), 3.38(2H, t), 3.67(4H, m), 7.10(1H, d), 7.17(1H, m), 7.27(2H, m), 7.33(1H, m), 7.40(1H, d), 7.57(1H, s) ESI MS(m/e) = 385 [M+l] Example 29. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-[4-(methylsulfonyI)phenyl]acetamide(29) 100mg(0.26mmol) of the compound obtained in Example 1 was dissolved in tetrahydrofuran, and 100mg(0.50mmol) of 4-methylthiophenylacetyl chloride was then added thereto. The mixture was heated under reflux for 2 hours. The solvent was removed under reduced pressure, ethyl acetate was added thereto, and then the organic phase was washed with water. The solvent was removed under reduced pressure, the solid thus obtained was dissolved in dichloromethane, and then 60mg(0.36mmol) of m- chloroperbenzoic acid was added thereto. The mixture was stirred at room temperature for one hour. 10% sodium thiosulfate was added thereto, and then the mixture was further stirred for one hour. The organic phase was separated and washed with water. Dichloromethane was removed, and 10ml of tetrahydrofuran and 3 ml of aqueous 2N sodium hydroxide solution were added to the solid. The mixture was stirred for 2 hours. The resultant was extracted with ethyl acetate, and then the extracted ethyl acetate solution was washed with water three times. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: methanol/dichloromethane = 5/95(v/v)) to give 60mg of the title compound in a yield of 51%. Η NMR (DMSO-d 5 , ppm): δ 2.39(2H, p), 3.21(3H, s), 3.46(2H, t), 3.68(2H, t), 3.89(2H, s), 7.34(2H, dd), 7.46(2H, d), 7.57(2H, m), 7.65(2H, d), 7.91(2H, d) API MS(m/e) = 449 [M+l] Example 30. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yl)-lH-indazol- 3-yl]-2-(4-methyl-l-piperazinyl)acetamide(30) The procedure was carried out according to the same procedure as Example 2, except that 2-bromoacetyl bromide was used instead of 3-chlorophenylacetyl chloride. Then, N,N-dimethylformamide was added thereto to form a solution. Anhydrous potassium carbonate and 4-methylpiperazine were added to the solution. The mixture was stirred for 2 hours. The solvent was removed by evaporation under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: methanol/dichloromethane = 5:95(v/v)) to give the title compound in a yield of 21%. ΗNMR (CD 3 OD, ppm): δ 2.48(5H, m), 2.82(8H, br s), 3.34(2H, s), 3.42(2H, t), 3.80(2H, t), 7.46(2H, m), 7.72(1H, s) API MS(m/e) = 393 [M+l] Example 31. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(4-morpholinyl)acetamide(31) The title compound was obtained in a yield of 31% according to the same procedure as Example 30, except that morpholine was used instead of 4-methylpiperazine. Η NMR (CD 3 OD, ppm): δ 2.48(2H, m), 2.64(4H, br s), 3.41(2H, t), 3.77(8H, m), 7.45(2H, m), 7.71(1H, s) API MS(m/e) = 380 [M+l] Example 32. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(l-piperidinyl)acetamide(32) The title compound was obtained in a yield of 33% according to the same procedure as Example 30, except that piperidine was used instead of 4-methylpiperazine. Η NMR (CD 3 OD + CDCI 3 , ppm): δ 1.45(2H, br s), 1.68(4H, m), 2.52(2H, m), 2.61(4H, br s), 3.20(2H, s), 3.41(2H, t), 3.81(2H, t), 7.45(2H, m), 7.77(1H, s) ESI MS(m e) = 378 [M+l] Example 33. Synthesis of N-[5-(l,l~dioxo-lλ 6 -isothiazoIidin-2-yl)-lH~indazol- 3~yl]-2-[4-(4-pyridinyI)phenyl]acetamide(33) 150mg(0.373mmol) of the compound obtained in Preparation 1 was dissolved in 10ml of tetrahydrofuran, and then 100mg(0.373mmol) of 4-pyridinylphenylacetyl chloride was added thereto. The mixture was heated under reflux for 2 hours. After the solvent was removed under reduced pressure, the residue was treated with ethyl acetate and water to give 16mg of the title compound as a solid in a yield of 10%. Η NMR (DMSO-d 6 , ppm): δ 2.38(2H, m), 3.45(2H. t), 3.67(2H, t), 3.81(2H, s), 7.35(1H, d), 7.46(2H, d), 7.56(3H, m), 7.72(2H, d), 7.80(2H, d), 8.63(3H, d), 10.69(1H, s) API MS(m/e) = 448 [M+l] Example 34. Synthesis of N~[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-[4-(4-piperidinyι)phenyl]acetamide(34) 130mg(0.337mmoι) of the compound obtained in Preparation 1 was added to 10ml of tetrahydrofuran, and then 109mg(0.502mmol) of 4-nitrophenylacetyl chloride was added thereto. The mixture was heated under reflux for 2 hours. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: hexane/ethylacetate = l :4(v/v)) to give 30mg of the title compound in a yield of 20%. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 1.55(2H, m), 1.69(4H, m), 2.51(2H, m), 3.09(4H, m), 3.38(2H, t), 3.70(2H, s), 3.78(2H, t), 6.95(2H, d), 7.26(2H, d), 7.40(2H, m), 7.63(1H, s) API MS(m/e) = 454 [M+l] Example 35. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yI]-2-[4-(4~morphoIinyI)phenyI]acetamide(35) 35-1) Synthesis of ethyl 2-[4-(4-morpholinyl)phenyl]-2-oxoacetate 0.25g(1.53mmol) of 4-phenylmorpholine was dissolved in 20ml of dichloromethane, was added 0.19ml(1.68mmol) of diethyloxalyl chloride at -10 ° C . 3.4ml(3.37mmol) of 1.0M titanium chloride solution(in dichloromethane) was added dropwise at -10 ° C, and then the mixture was stirred for 4 hours while keeping the temperature at -10 ° C . The mixture was poured into ice water, and then extracted with diethyl ether three times. The resulting product was concentrated under reduced pressure, and then purified by silica gel column chromatography (eluent: hexane/ethylacetate = 2/l(v/v)) to give 0.15mg of the title compound in a yield of 38%. Η NMR (CDCI 3 ppm): δ 1.40(3H, t), 3.37(4H, t), 3.84(4H, t), 4.41(2H, q), 6.85(2H, d), 7.92(2H, d) 35-2) Synthesis of ethyl 2-[4-(4-morpholinyl)phenyl] acetate 0.5g(1.901mmol) of the compound obtained in Example 35-1) was added to a solvent mixture (dioxane/water = 10ml/0.5ml), and then 1.007g(9.505mmol) of sodium hypophosphite hydrate and 0.05g of palladium-adsorbed activated carbon(10%) were added thereto. The mixture was heated under reflux for 5 hours, and then cooled to room temperature. Additional 1.007g(9.505mmol) of sodium hypophosphite hydrate and 0.05g of palladium-adsorbed activated carbon(10%) were added to the mixture. The mixture was stirred for another 5 hours. The resulting suspension was filtered through celite, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethylacetate = 2:l(v/v)) to give 0.37g of the title compound in a yield of 78%. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 1.25(3H, t), 3.14(4H, m), 3.52(2H, s), 3.85(4H, m), 4.14(2H, m), 6.88(2H, d), 7.18(2H, d) 35-3) Synthesis of 2-[4-(4-morpholinyl)phenyl]acetyl chloride 0.35g(1.41mmol) of the compound obtained in Example 35-2) was dissolved in 12ml of tetrahydrofUran, and then 0.18g(4.23mmol) of lithium hydroxide in 4ml of water was added thereto. The mixture was stirred for 12 hours. The solvent was removed under reduced pressure. The residue was dissolved in 15ml of dichloromethane, and then 5 molar equivalents of thionyl chloride was added thereto. The mixture was stirred at room temperature for 4 hours. The solvent was removed by evaporation under reduced pressure to give 0.44g of the title compound. The compound was used for subsequent reactions without further purification processes. 35-4) Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4- (4-morpholinyl)phenyl]acetamide 0.2g(0.518mmoι) of the compound obtained in Preparation 1 was added in 40ml of tetrahydrofuran, and then 0.316g(1.2mmol) of 4-morpholinylphenylacetyl chloride was added thereto. The mixture was heated under reflux for 7 hours. Subsequently, the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 19:l(v/v)) to give lOmg of the title compound in a yield of 4%. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 2.47(2H, m), 3.10(4H, m), 3.34(2H, t), 3.67(2H, s), 3.75(2H, t), 3.81(4H, 4H), 6.87(2H, d), 7.25(2H, d), 7.31(1H, d), 7.39(1H, d), 7.67(1H, s) API MS(m/e) = 456 [M+l] Example 36. Synthesis of N-[5~(l,l~dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-[4-(3-thienyl)phenyl]acetamide(36) 106mg(0.28mmol) of the compound obtained in Preparation 1 was added to 10ml of tetrahydrofuran, and then 97mg(0.41mmol) of 4-(3-thienyl)phenylacetyl chloride was added thereto. The mixture was heated under reflux for 2 hours. After the resulting mixture was cooled to room temperature, 5ml of aqueous IN sodium hydroxide solution thereto. The mixture was stirred for 2 hours. The resultant was extracted with ethyl acetate, and then washed with water three times. The solvent was removed under reduced pressure, and the residue was then treated with . methanol to give 51mg of the title compound in a yield of 41%. Η NMR (DMSO-d 6 , ppm): δ 2.37(2H, m), 3.45(2H, t), 3.66(2H t), 3.74(2H, s), 7.35(1H, d) 7.43(2H, d), 7.46(1H, d), 7.54(1H, d), 7.56(1H, d), 7.63(1H, dd), 7.70(2H, d), 7.85(1H, s), 10.63(1H, s) ESI MS(m e) = 453 [M+l] Example 37. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-[4-(4-morpholinylsulfonyl)phenyl]acetamide(38) 81mg(0.21mmol) of the compound obtained in Preparation 1 was added to 10ml of tetrahydrofuran, and then 91mg(0.32mmol) of 4-(4-morpholinylsulfonyl)phenylacetyl chloride was added thereto. The mixture was heated under reflux for 2 hours. After the resulting mixture was cooled to room temperature, 5ml of aqueous IN sodium hydroxide solution thereto. The mixture was stirred for 2 hours. The resultant was extracted with ethyl acetate, and then washed with water three times. The solvent was removed under reduced pressure, and the residue was then treated with diethyl ether to give 69mg of the title compound in a yield of 63%. Η NMR (DMSO-d 6 , ppm): δ 2,39(2H, m), 2,S7(4H, br), 3.45(2H, t), 3.62(4H, br), 3.68(2H, t), 3.90(2H, s), 7.35(1H, d), 7.47(1H, d), 7.56(1H, s), 7.67(2H, d), 7.73(2H, d), 10.73(1H, s) ESI MS(m e) = 520 [M+l] Example 38. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yI)-lH-indazoI- 3-yl]-2-(4-methoxyphenyI)acetamide(37) 60mg of the title compound was obtained in a yield of 58% according to the same procedure as Example 2, except that 4-methoxyphenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (DMSO-d 6 OD, ppm): δ 2.39(2H, m), 3.46(2H, t), 3.68(4H, m), 3.74(3H, s), 6.91(2H, d), 7.31(3H, m), 7.45QH, d), 7.55(1H, s) API MS(m/e) = 401 [M+l] Example 39. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazoIidin~2-yl)-lH-indazol- 3-yl]-2-[4-(2-furyl)phenyl]acetamide(39) 24mg(0.06mmol) of the compound obtained in Preparation 1 was added to 10ml of tetrahydrofuran, and then 21mg(0.09mmol) of 4-(2-furyl)phenylacetyl chloride was added thereto. The mixture was heated under reflux for 2 hours. After the resulting mixture was cooled to room temperature, 5ml of aqueous IN sodium hydroxide solution thereto. The mixture was stirred for 2 hours. The resultant was extracted with ethyl acetate, and then washed with water three times. The solvent was removed under reduced pressure, and the residue was then treated with dichloromethane to give 13mg of the title compound in a yield of 48%. Η NMR (DMSO-d 6 , ppm): δ 2,38(2H, m), 3.45(2H, t), 3.69(2H, t), 3.75(2H, s), 6.58(1H, s), 6.91(1H, s), 7.35(1H, d), 7.45(3H, m), 7.55(1H, s), 7.68(2H, d), 7.73(1H, s), 10.63(1H, s) ESI MS(m/e) = 437 [M+l] Example 40. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazoI- 3-yl]-2~4-[(4-methyl-l-piperazinyl)sulfonyl]phenylacetamide(40) 69mg(0.178mmol) of the compound obtained in Preparation 1 was added to 10ml of tetrahydrofuran, and then 112mg(0.355mmol) of 4-[(4-methyl-l- piperazinyl)sulfonyl]phenylacetyl chloride was added thereto. The mixture was heated under reflux for 2 hours. After the resulting mixture was cooled to room temperature, 5ml of aqueous IN sodium hydroxide solution thereto. The mixture was stirred for 2 hours. The resultant was extracted with ethyl acetate, and then washed with water three times. The solvent was removed under reduced pressure, and the residue was then purified by silica gel column chromatography (eluent: dichloromethane/methanol = 9/1 (v/v)) to give 12mg of the title compound in a yield of 13%. Η NMR (CDC1 3 , ppm): δ 2.26(3H, s), 2.48(4H, br), 2.51(2H, m), 3.08(4H, br), 3.39(2H, t), 3.47(2H, s), 3.79(2H, t), 7.30(1H, d), 7.43(1H, d), 7.80(2H, d), 7.90(1H, s), 8.43(2H, d), 8.72(1H, s) ESI MS(m/e) = 533 [M+l] Example 41. Synthesis of 2-(lH-benzimidazoI-l-yl)-N-[5-(l,l-dioxo-lλ 6 -iso- thiazolidin-2-yI)-lH-indazol-3-yl]acetamide(41) 41-1) Synthesis of benzyl 3[(2-bromoacetyl)amino]-5-(l,l-dioxo-lλ 6 - isothiazolidin-2-yl)- lH-indazol- 1 -carboxylate 0.5g(1.404mmol) of the compound obtained in Preparation 1 was added to 25ml of tetrahydrofuran, and then 0.147ml(1.2eq) of bromoacetyl bromide was added thereto. The mixture was heated under reflux for one hour. After the solvent was removed by evaporation under reduced pressure, the residue was purified by silica gel column chromatography (eluent: ethylacetate/hexane = 4/1 (v/v)) to give 0.47g of the title compound in a yield of 66%. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 2.53(2H, m), 3.42(2H, t), 3.82(2H, t), 4.04(2H, s), 5.47(2H, s), 7.34(3H, m), 7.45(2H, m), 7.57(1H, dd), 7.79(1H, s), 8.00(1H, s). 41-2) Synthesis of 2-(lH-benzimidazol-l-yl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin- 2-y 1)- 1 H-indazol-3 -yl] acetamide 20mg(0.169mmol) of benzimidazole was dissolved in 10ml of N,N- dimethylformamide, and then 20mg(0.5mmol) of sodium hydride was added thereto. After 5 minutes, 70mg(0.38mmol) of the compound in Example 41-1 was added thereto. The mixture was stirred for one hour. The solvent was removed under reduced pressure, and the residue was then treated with ethyl acetate to give 20mg of the title compound in a yield of 35%. Η NMR (DMSO-d 6 OD, ppm): δ 2.36(2H, m), 3.44(2H, t), 5.29(2H, s), 7.25(2H, m), 7.35QH, d), 7.48(1H, d), 7.59(2H, m), 7.70(1H, d), 8.28(1H, s) ESI MS(m/e) = 411 [M+l] Example 42. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(4-ethoxyphenyl)acetamide(42) 22mg of the title compound was obtained in a yield of 41% according to the same procedure as Example 2, except that 4-ethoxyphenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. ΗNMR (DMSO-d 6 OD, ppm): δ 1.32(3H, t), 2.40(2H, m), 3.46(2H, t), 3.67(4H, m), 4.01(2H, m), 6.90(2H, d), 7.30(3H, m), 7.45(1H, d), 7.55(1H, s), 10.53(1H, s) API MS(m/e) = 413 [M+l] Example 43. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yl)-lH-indazol- 3-yI]-2-[4-(4-morpholinylmethyl)phenyl]acetamide(43) lg(2.591mmol) of the compound obtained in Preparation 1 was added to 80ml of tetrahydrofuran, and then 0.8g(1.2eq) of 4-(bromomethyl)phenylacetyl bromide was added thereto. The mixture was heated under reflux for 2 hours. The solvent was removed under reduced pressure, and the residue was then purified by silica gel column chromatography (eluent: hexane/ethylacetate = l/4(v/v)) to give 0.9g of the title compound in a yield of 58%. 0.1g(0.168mmol) of the compound thus obtained was dissolved in 15ml of N,N- dimethylformamide, and then 0.03ml(2.0eq) of morpholine and 50mg(2.0eq) of anhydrous potassium carbonate were added thereto. The mixture was stirreat at 60 °C for 2 hours. The solvent was removed under reduced pressure, and the residue was then purified by silica gel column chromatography (eluent: dichloromethane/methanol = 19/1 (v/v)) to give 55mg of the title compound in a yield of 65%. Η NMR (DMSO-d 6 OD, ppm): δ 2.34(4H, br s), 2.39(2H, m), 3.46(4H, m), 3.57(4H, m), 3.73(4H, m) 7.27(2H, d), 7.34(2H, m), 7.36(3H, m), 7.46(1H, d), 7.57(1H, s) API MS(m/e) = 456 [M+l] Example 44. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazoI- 3-yl]-2-4-[(4-methyl-l-piperazinyl)methyI]phenylacetamide(44) 44mg of the title compound was obtained in a yield of 54% according to the same procedure as Example 43, except that 4-methylpiperazine was used instead of morpholine. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 1.99(3H, s), 2.24(8H, m), 3.04(2H, m), 3.11(2H, t), 3.22(2H, s), 3.51(4H, m), 7.01(2H, d), 7.11(4H, m), 7.40(1H, s) ESI MS(m/e) = 482 [M+l] Example 45. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(4-nitrophenyl)acetamide(45) 386mg(1.0mmol) of the compound obtained in Preparation 1 was added to 10ml of tetrahydrofuran, and 299mg(1.5mmol) of 4-nitrophenylacetyl chloride was added thereto. The mixture was heated under reflux for 2 hours. After the mixture was cooled to room temperature, 5ml of aqueous IN sodium hydroxide solution was added thereto. The mixture was stirred for 2 hours. The resultant was extracted with ethyl acetate, and then the extracted ethyl acetate solution was washed with water three times. After the solvent was removed under reduced pressure, the residue was treated with methanol to give 151mg of the title compound as a solid in a yield of 36%. Η NMR (DMSO-d 6 , ppm): δ 2.39(2H, m), 3.54(2H, t), 3.68(2H, t), 3.93(2H, s), 7.34(1H, d), 7.47(1H, d), 7.57(1H, s), 7.67(2H, d), 8.22(2H, d), 10.72(1H, s) ESI MS(m/e) = 416 [M+l] Example 46. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yI)-lH-indazol- 3~yl]-2-[4-(lH-imidazoI-l-ylmethyl)phenyl]acetamide(46) 50mg of the title compound was obtained in a yield of 66% according to the same procedure as Example 43, except that imidazole was used instead of morpholine. Η NMR (CDCD3+ CD 3 OD, ppm): δ 2.28(2H, m), 3.05(2H, s), 3.16(2H, t), 3.53(4H, m), 6.70(2H, d), 6.89(2H, d), 7.12(2H, m), 7.22(2H, d) 7.55(1H, s), 7.79(1H, d) ESI MS(m/e) = 451 [M+l] Example 47. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yI)-lH-indazol- 3-yl]-2-(4-phenyl-lH-imidazol-l-yl)acetamide(47) lOmg of the title compound was obtained in a yield of 17% according to the same procedure as Example 41, except that 4-phenylimidazole was used instead of benzimidazole. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 2.25(2H, m), 3.13(2H, t), 3.53(2H, t), 4.71(2H, s), 7.00(1H, m), 7.11(2H, m), 7.19(3H, m), 7.46(4H, m) ESI MS(m/e) = 437 [M+l] Example 48. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(4-phenyl-l-piperazinyI)acetamide(48) 20mg of the title compound was obtained in a yield of 32% according to the same procedure as Example 41, except that 4-phenylpiperazine was used instead of benzimidazole. Η NMR (CDCI 3 + CD 3 OD +DMSO-d 6 , ppm): δ 2.42(2H, m), 2.74(4H, m), 3.21(4H, m), 3.38(2H, t), 3.72(4H, m), 6.75(1H, t), 6.90(2H, d), 7.17(2H, m) 7.37(2H, dd), 7.42(1H, d), 7.67(1H, s) ESI MS(m/e) = 456 [M+l] Example 49. Synthesis of 2-[3,4-dihydro-2(lH)-isoquinolinyl]-N-[5-(l,l-dioxo- lλ 6 -isothiazolidin-2-yI)-lH-indazoI-3-yI]acetamide(49) 57mg of the title compound was obtained in a yield of 68% according to the same procedure as Example 41, except that 3,4-dihydro-2(lH)-isoquinoline was used instead of benzimidazole. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 2.56(2H, m), 3.03(4H, m), 3.43(4H, m), 3.85(4H, m), 7.08(4H, m), 7.45(2H, m), 7.83(1H, s) ESI MS(m/e) = 426 [M+l] Example 50. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-[4-(4-chlorophenyl)-l-piperazinyl]acetamide(50) 20mg of the title compound was obtained in a yield of 41% according to the same procedure as Example 41, except that 4-(4-chlorophenyl)piρerazine was used instead of benzimidazole. 'H NMR (CDC1 3 + CD 3 OD, ppm): δ 2.55(2H, m), 2.86(4H, m), 3.36(6H, m), 3.44(2H, t), 3.87(2H, t) 6.87(3H, m), 7.19(1H, t), 7.47(2H, m), 7.82(1H, s) ESI MS(m/e) = 490 [M+l] Example 51. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yl)-lH-indazoI- 3-yI]-2-[4-(4-methoxyphenyI)-l-piperazinyl]acetamide(51) 25mg of the title compound was obtained in a yield of 53% according to the same procedure as Example 41, except that 4-(4-methoxyphenyl)piperazine was used instead of benzimidazole. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 2.56(2H, m), 3.44(1 OH, m), 3.83(5H, m), 4.16(2H, s), 6.92(4H, m), 7.46(2H, m), 7.85(1H, s) ESI MS(m/e) = 485 [M+l] Example 52. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-[4-(2-ethoxyphenyI)-l-piperazinyl]acetamide(52) 15mg of the title compound was obtained in a yield of 20% according to the same procedure as Example 41, except that 4-(2-ethoxyphenyl)piperazine was used instead of benzimidazole. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 1.48(3H, t), 2.56(2H, m), 2.91(4H, m), 3.22(4H, m), 3.34(2H, m), 3.43(2H, t), 3.85(2H, t), 4.11(2H, m), 7.00(4H, m), 7.45(2H, m), 7.85(1H, s) API MS(m/e) = 499 [M+l] Example 53. Synthesis of 2-[4-(4-acetylphenyI)-l-piperazinyl]-N-[5-(l,l-dioxo- lλ 6 -isothiazoIidin-2-yl)-lH-indazoI-3-yl]acetamide(53) 25mg of the title compound was obtained in a yield of 51% according to the same procedure as Example 41, except that 4-(4-acetylphenyl)piperazine was used instead of benzimidazole. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 2.55(4H. m), 2.86(2H, m), 3.43(8H, m), 3.84(2H, t), 4.06(3H, s), 6.93(2H, m), 7.46(2H, m), 7.86QH, s), 7.90(2H, m) API MS(m/e) = 498 [M+l] Example 54. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(4-phenoxyphenyl)acetamide(54) 25mg of the title compound was obtained in a yield of 30% according to the same procedure as Example 2, except that (4-phenoxyphenyl)acetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 2.44(2H, m), 3.39(2H, t), 3.72(4H, m), 7.02(5H, m), 7.34(6H, m), 7.68(1H, s) ESI MS(m/e) = 463 [M+l] Example 55. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-l-phenyIcyclopentanecarboxamide(55) 24mg of the title compound was obtained in a yield of 31% according to the same procedure as Example 2, except that 1-phenylcyclopentanecarbonyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 1.74(4H, m), 2.04(2H, m), 2.49(4H, m), 3.38(2H, t), 3.68(2H, t), 7.20(5H, m), 7.38(2H, m), 7.48(1H, s) ESI MS(m/e) = 425 [M+l] Example 56. Synthesis of 2-cycIopentyl-N-[5-(l,l-dioxo-lλ 6 -isothiazoIidin-2- yI)-lH-indazol-3-yI]-2-phenylacetamide(56) 30mg of the title compound was obtained in a yield of 38% according to the same procedure as Example 2, except that 2-cyclopentyl-2-phenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 1.61(6H, m), 2.11(1H, m), 2.51(2H, m), 2.79(1H, m), 3.45(4H, m), 3.78(2H, t), 7.32(5H, m), 7.54(2H, m), (IH, s) ESI MS(m/e) = 439 [M+l] Example 57. Synthesis of N-[5-(l,l~dioxo-lλ 6 -isothiazoIidin-2-yl)-lH-indazoI- 3-yl]-2-phenylbutanamide(57) 35mg of the title compound was obtained in a yield of 48% according to the same procedure as Example 2, except that 2-phenylbutanoyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 0.94(3H, t), 1.84(1H, m), 2.17(1H, m), 2.46(2H, m), 3.34(2H, t), 3.57(1H, t), 3.72(2H, t), 7.23(5H, m), 7.38(2H, m), 7.56(1H, s) ESI MS(m/e) = 399 [M+l] Example 58. Synthesis of t-butyl 4-(2-[5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yl)- lH-indazol-3-yl]amino-2-oxoethyl)-l,3-thiazol-2-ylcarbamate(58) 58-1) Synthesis of t-butyl 4-2-[(5-nitro-lH-indazol-3-yl)amino]-2-oxoethyl-l,3- thiazol-2-ylcarbamate 2.0g(10.204mmol) of amino-N-hydroxy-5-nitrobenzenecarboxyimidoamide was dissolved in 120ml of tetrahydrofuran, and then 0.82g(60%, 2,0eq) of sodium hydride was added thereto. After stirring 5 minutes at room temperature, was added 3.5 g(1.2eq) of ethyl 2-2-[(t-butyloxycarbonyl)amino]-l,3-thiazol-4-ylacetate and stirred for one hour. After addition of 20 ml of N,N-dimethylformamide, further stirred under slight heating for 4 hours. The solvent was removed under reduced pressure, and the residue was then treated with ethyl acetate and water. The resulting precipitate was filtered and washed with water and diethyl ether to give 1.9g of the title compound in a yield of 42%. 58-2) Synthesis of t-butyl 4-2-[(5-amino-lH-indazol-3-yl)amino]-2-oxoethyl-l,3- thiazol-2-ylcarbamate 1.9g(4.24mmol) of the compound obtained in Preparation 58-1) was dissolved in methanol, and palladium-adsorbed activated carbon(10%) was added thereto. The mixture was stirred under hydrogen atmosphere for 2 hours. The resulting suspension was filtered through celite, and then the filtrate was concentrated and dried to give 1.7g of the title compound in a yield of 96%. 58-3) Synthesis of t-butyl 4-2-[(5-[(3-chloropropyl)sulfonyl]amino-lH-indazol-3- yl)amino]-2-oxoethyl-l,3-thiazol-2-ylcarbamate 1.7g(4.07mmol) of the compound obtained in Preparation 58-2) was dissolved in 100ml of dichloromethane, and 1.53ml(5.0eq) of pyridine and 0.49ml(1.0eq) of 3- chloropropanesulfonyl chloride were added thereto. The mixture was stirred at room temperature for 2 hours. After the solvent was removed under reduced pressure, the residue was treated with ethyl acetate and water to give 0.8g of the title compound as a solid in a yield of 37%. 'H NMR (CDC1 3 + CD 3 OD, ppm): δ 1.35(9H. s), 2.07(2H, m), 3.02(2H, t), 3.45(2H, t),3.69(2H, s), 6.60(1H, s), 7.20(2H, m), 7.60(1H, s) API MS(m/e) = 529 [M+l] 58-4) Synthesis of t-butyl 4-(2-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]amino-2-oxoethyl)-l,3-thiazol-2-ylcarbamate 0.7g(1.33mmol) of the compound obtained in Preparation 58-3) was dissolved in 50ml of N,N-dimethylformamide, and 0.16g(3.0eq) of sodium hydride was added thereto. The mixture was stirred for 3 hours. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: n- hexane/ethyl acetate = l/4(v/v)) to give O.lg of the title compound in a yield of 15%. Η NMR (CD 3 OD, ppm): δ 1.53(9H, s), 2.49(2H, m), 3.42(2H, t), 3.80(4H, m), 6.90(1H, s), 7.44(2H, m), 7.67(1H, s) API MS(m/e) = 493 [M+l] Example 59. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-4-[2-(2-ethoxyethoxy)ethoxy]phenyIacetamide(59) 59-1) Synthesis of 2-(2-ethoxyethoxy)ethyl 4-methylbenzenesulfonate 432mg(3.22mmoι) of 2-(2-ethoxyethoxy)ethanol was dissolved in 40ml of dichloromethane, and 0.6ml(4.19mmol) of triethylamine and 614mg(3.22mmol) of p- toluenesulfonyl chloride were added thereto. The mixture was stirred at room temperature for 15 hours. After the solvent was removed under reduced pressure, 40ml of water was added thereto. The mixture was extracted with 30ml of ethyl acetate. The solvent was removed under reduced pressure to give 760mg(2.64mmol) of the title compound in a yield of 82%. Η NMR (CDC1 3 , ppm): 6 1.20(3H, t), 2.35(3H, s), 3.35(2H, q), 3.52(2H, t), 3.57-3.60(4H, m), 4.08(2H, t), 7.33(2H, d), 7.78(2H, d) FAB MS(m/e) = 289 [M+l] 59-2) Synthesis of 2-4-[2-(2-ethoxyethoxy)ethoxy]phenylacetic acid 281mg(0.97mmol) of the compound obtained in Example 59-1) and 162mg(0.971mmol) of 4-hydroxyphenylacetic acid methyl ester were dissolved in 30ml of N,N-dimethylformamide, and then 58mg(1.44mmol) of sodium hydride(60%) was added thereto. The mixture was stirred at room temperature for one hour. After the reaction was completed, 3ml of methanol was added thereto. The solvent was removed under reduced pressure, and 40ml of water was added thereto. The mixture was extracted with 30ml of ethyl acetate. The solvent was removed under reduced pressure, and the residue was then purified by silica gel column chromatography to give 64mg(0.239mmol) of the title compound in a yield of 24%. Η NMR (CDCI 3 , ppm): δ 1.21(3H, t), 3.34(2H, q), 3.51(2H, t), 3.57-3.61(4H, m), 3.82(2H, s), 4.06(2H, t), 6.86(2H, d), 7.17(2H, d) FAB MS(m/e) = 269 [M+l] 59-3) Synthesis of N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-4- [2-(2-ethoxyethoxy)ethoxy]phenylacetamide 60mg(0.224mmol) of the compound obtained in Example 59-2 was dissolved in 15ml of dichloromethane, and then 0.005ml of N,N-dimethylformamide and 0.05ml(0.685mmol) of thionyl chloride were added thereto. The mixture was stirred for one hour. The solvent and the unreacted thionyl chloride were removed under reduced pressure. The residue was dissolved in 15ml of tetrahydrofuran, and 79mg(0.203mmol) of the compound obtained in Preparation 1 was added thereto. The mixture was heated to reflux for 2 hours. After cooled to room temperature, lml(2mmol) of aqueous 2N sodium hydroxide solution was added and the mixture was stirred at room temperature for 10 hours. After the reaction was completed, the mixture was concentrated and 30ml of water was added. The mixture was extracted with 20ml of ethyl acetate and then concentrated again. 37mg(0.074mmol, yield 36%) of the title compound was isolated by silica gel column chromatography. l H NMR (CDC1 3 , ppm): δ 1.20(3H, t), 2.51(2H, t), 3.32(2H, q), 3.52(2H, t), 3.62-3.87(10H, m), 4.15(2H, t), 6.90(2H, d), 7.27(2H, d), 7.50(1H, d), 7.76(1H, d), 7,82(1H, s), 9.80(1H, s) FAB MS(m/e) = 503 [M+l] Example 60. Synthesis of 2-(2-amino-l,3-thiazol-4-yl)-N-[5-(l,l-dioxo-lλ 6 -iso- thiazolidin-2-yl)-lH-indazol-3-yl]acetamide(60) 0.1g(0.203mmol) of the compound obtained in Example 58 was dissolved in 15ml of dichloromethane, and then 6ml of trifluoroacetic acid was added thereto. The mixture was stirred at room temperature for two hours. The solvent was removed under reduced pressure to give 40mg of the title compound in a yield of 50%. Η NMR (CD 3 OD, ppm): δ 2.50(2H, m), 3.42(2H, t), 3.70(2H, s), 3.80(2H, t), 6.45(1H, s), 7.46(2H, m), 7.70(1H, s) ESI MS(m/e) = 393 [M+l] Example 61. Synthesis of 2-[4-(4-bromophenyl)-lH-imidazol-l-yl]-N-[5-(l,l- dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]acetamide(61) 10mg of the title compound was obtained in a yield of 10% according to the same procedure as Example 41, except that 4-(4-bromophenyl)imidazole was used instead of benzimidazole. Η NMR (CD 3 OD, ppm): δ 2.47(2H, m), 3.39(2H, t), 3.77(2H, t), 5.05(2H, s), 7.43(2H, s), 7.46(2H, d), 7.52(1H, s), 7.60(2H, d), 7.69(1H, s), 7.75(1H, s) ESI MS(m/e) = 515 [M+l] Example 62. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-[4-(2-naphthyl)-lH-imidazol-l-yl]acetamide(62) 20mg of the title compound was obtained in a yield of 21% according to the same procedure as Example 41, except that 4-(2-naphthyl)imidazole was used instead of benzimidazole. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 2.42(2H, m), 3.34(2H, t), 3.72(2H, t), 4.96(2H, s), 7.38(4H, m), 7.51(1H, m), 7.77(6H, m), 8.16(1H, s) ESI MS(m/e) = 487 [M+l] Example 63. Synthesis of 2-(4-[l,l'-biphenyl]-4-yl-lH-imidazol-l-yl)-N-[5- (l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]acetamide(63) 15mg of the title compound was obtained in a yield of 10% according to the same procedure as Example 41, except that 4-([l, 1 '-biphenyl] -4-yl)imidazole was used instead of benzimidazole. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 2.48(2H, m), 3.36(2H, t), 3.76(2H, t), 4.95(2H, s), 7.29(1H, m), 7.39(3H, m), 7.45(1H, d), 7.59(5H, m), 7.70(2H, d), 7.77(2H, d) ESI MS(m/e) = 513 [M+l] Example 64. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-[2-(ethylamino)-l,3-thiazol-4-yl]acetamide(64) Example 65. Synthesis of 2-[2-(diethylamino)-l,3-thiazol-4-yl]-N-[5-(l,l-di- oxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]acetamide(65) 36mg(0.092mmol) of the compound obtained in Example 60 was dissolved in 15ml of N,N-dimethylformamide, and then 0.016ml(3.0eq) of acetaldehyde and 40mg of sodium triacetoxyborohydride 40mg were added thereto. The mixture was stirred for 12 hours. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 19/1 (v/v)) to give 2mg of the compound of Example 64 in a yield of 5% and 3mg of the compound of Example 65 in a yield of 7%. Example 64. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[2-(eth- ylamino)- 1 , 3 -thiazol-4-yl] acetamide Η NMR (CDC1 3 + CD 3 OD, ppm): δ 1.25(3H, t), 2.52(2H, m), 3.29(2H, m), 3.40(2H, t), 3.66(2H, s), 3.81(2H, t), 6.36(1H, s), 7.42(2H, m), 7.73(1H, s) API MS(m/e) = 421 [M+l] Example 65. 2-[2-(diethylamino)-l,3-thiazol-4-yl]-N-[5-(l, 1 -dioxo- lλ 6 -isothiazo- lidin-2-yl)-lH-indazol-3-yl]acetamide 2 H NMR (CDC1 3 + CD 3 OD, ppm): δ 1.24(6H, m), 2.53(2H, m), 3.30(2H, m), 3.40(2H, t) 3.40(2H, m), 3.81(2H, t), 4.39(2H, s), 6.38(1H, d), 7.43(2H, m), 7.71(1H, d) ESI MS(m/e) = 449 [M+l] Example 66. Synthesis of N-[5-(l,l-dioxo-lλ δ -isothiazoIidin-2-yI)-lH-indazol- 3-yl]-2-(4-2-[2-(2-methoxyethoxy)ethoxy]ethoxyphenyl)acetamide(66) 68mg(0.128mmmol) of the title compound was obtained in a yield of 34% according to the same procedure as Example 59, except that 2-[2-(2- methoxyethoxy)ethoxy] ethanol was used instead of 2-(2-ethoxyethoxy)ethanol. Η NMR (DMSO-d 6 , ppm): 6 2.51(2H, t), 3.22(3H, s), 3.32-3.81(16H, m), 4.15(2H, t), 6.91(2H, d), 7.29(2H, d), 7.40(1H, d), 7.44(1H, d), 7.53(1H, s), 10.50(1H, s) FAB MS(m/e) = 533 [M+l] Example 67. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(4-ethoxy-3-nitrophenyl)acetamide(67) 67-1) Synthesis of 4-ethoxy-3-nitrophenylacetic acid 1.08 g(6.0mmol) of 4-ethoxyphenylacetic acid was dissolved in 12ml of acetic anhydride, and then 1.45g(6.0mmol) of cupric nitrate was added thereto. The mixture was stirred at 0 ° C for one hour. The resulting mixture was extracted with ethyl acetate, and then washed with water three times. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 95/5(v/v)) to give 1.30mg of the title compound in a yield of 94%. Η NMR (CDC1 3 , ppm): δ 1.44(3H, t), 3.62(2H, s), 4.16(2H, q), 7.02(1H, d), 7.41(1H, d) 7.73(1H, s) ESI MS(m/e) = 224 [M+l] 67-2) Synthesis of 4-ethoxy-3-nitrophenylacetyl chloride 153mg(0.68mmol) of the compound obtained in Example 67-1 was dissolved in dichloromethane, and then 0.15ml(2.04mmol) of thionyl chloride was added thereto. The mixture was stirred for 2 hours. The solvent was removed under reduced pressure to give the title compound quantatively. 67-3) Synthesis of N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4- ethoxy-3 -nitrophenyl)acetamide 190mg of the title compound was obtained in a yield of 79% according to the same procedure as Example 2, except that the compound obtained in Example 67-2 was used instead of 3-chlorophenylacetyl chloride. Η NMR (DMSO-d 6 , ppm): δ 1.34(3H, t), 2.39(2H, m), 2.04(2H, t), 3.46(2H, t), 3.68(2H, t), 3.78(2H, s), 4.21(2H, q), 7.34(1H, d), 7.35(1H, d), 7.47(1H, d), 7.56(1H, s), 7.63(1H, d), 7.87(1H, s), 10.65(1H, s) ESI MS(m/e) = 460 [M+l] Example 68. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yI]-2-(2-methylphenyl)acetamide(68) 32mg of the title compound was obtained in a yield of 64% according to the same procedure as Example 2, except that (2-methylphenyl)acetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (DMSO-d 5 , ppm): δ 2.23(3H, s), 2.39(2H, m), 3.46(2H, t), 3 ,68(2H, t), 3.77(2H, s), 7.17(3H, m), 7.31(2H, m), 7.34(1H, d), 7.46(1H, d), 7.58(1H, s), 10.58(1H, s) ESI MS(m/e) = 385 [M+l] Example 69. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazoI- 3-yl]~2-[3-(ethylamino)phenyl]acetamide(69) 30mg(0.78mmol) of the compound obtained in Example 21 was added to 5ml of N,N-dimethylformamide, and 10mg(0.234mmol) of acetaldehyde, 50mg(0.234mmol) of sodium triacetoxyborohydride and 14mg(0.234mmol) of glacial acetic acid were added. The mixture was stirred for 15 hours. After the removal of the solvent under reduced pressure, ethyl acetate and water was added. After basified with aqueous IN sodium hydroxide solution, ethyl acetate layer was collected and it was washed with water three times. The solvent was removed under reduced pressure, and the residue was then purified by silica gel column chromatography (eluent: ethyl acetate) to give lOmg of the title compound in a yield of 31%. Η NMR (CDC1 3 , ppm): δ 1.18(3H, t), 2.39(2H, m), 3.04(2H, q), 3.61(2H, t), 3.64(2H, s), 6.47(1H, d), 6.54(1H, s), 6.63(1H, d), 7.03(1H, d), 7.10(1H, t), 7.25(1H, s), 7.60(1H, s), 8.58(1H, s) ESI MS(m/e) = 414 [M+l] Example 70. Synthesis of 2-[3-(diethylamino)phenyl]-N-[5-(l,l-dioxo-lλ 6 -iso- thiazolidin-2-yl)-lH-indazol-3-yI]acetamide(70) The compound extracted with ethyl acetate in Example 69 was purified by silica gel column chromatography (eluent: ethylacetate) to give 3mg of the title compound in a yield of 9%. Η NMR (CDCI 3 , ppm): δ 1.15(6H, t), 2.48(2H, m), 3.35(6H, m), 3.74(2H, s), 3.76(2H, t), 6.62(3H, m), 7.21(2H, d), 7.42(1H, d), 7.76(1H, s), 8.07(1H, s) ESI MS(m e) = 442 [M+l] Example 71. Synthesis of 2-(3,5-dimethoxypheny_)-N-[5-(l,l~dioxo-lλ 6 -iso~ thiazolidin-2-yI)-lH-indazol-3-yl]acetamide(71) 50mg of the title compound was obtained in a yield of 89% according to the same procedure as Example 2, except that 3,5-dimethoxyphenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (DMSO-d 6 , ppm): δ 2.40(2H, m), 3.46(2H, t), 3.64(2H, s), 3.68(2H, t), 3.74(6H, s), 5.75(1H, s), 6.40(1H, s), 6.57(1H, s), 7.35(1H, d), 7.46(1H, d), 7.55(1H, s), 10.57(1H, s) ESI MS(m e) = 431 [M+l] Example 72. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yI] -2- [4-(ethylamin o)phenyl] acetamid e(72) 15mg(0.039mmol) of the compound obtained in Example 21 was dissolved in 5ml of N,N-dimethylformamide, and 5mg(0.117mmol) of acetaldehyde, 25mg(0.117mmol) of sodium triacetoxyborohydride and 7mg(0.117mmol) of glacial acetic acid were. After stirring for 15 hours, solvent was removed under reduced pressure, and ethyl acetate and water was added to the residue. After basified with aqueous IN sodium hydroxide solution, ethyl acetate layer was collected and it was washed with water three times. The solvent was removed under reduced pressure, and the residue was then purified by silica gel column chromatography (eluent: ethylacetate) to give 5mg of the title compound in a yield of 31%. ΗNMR (DMSO-d 6 , ppm): δ 1.14(3H, t), 2.39(2H, m), 3.01(2H m), 3.46(2H, t), 3.52(2H, s), 3.67(2H, t), 5.39(1H, s), 6.52(2H, d), 7.09(2H, d), 7.34(1H, d), 7.45(1H, d), 7.54(1H, s), 10.44(1H, s) ESI MS(m/e) = 414 [M+l] Example 73. Synthesis of 2-[4-(diethylamino)phenyI]-N-[5-(l,l-dioxo-lλ 6 -iso- thiazolidin-2-yl)-lH-indazol-3-yI]acetamide(73) The compound extracted with ethyl acetate in Example 73 was purified by silica gel column chromatography (eluent: ethylacetate) to give lmg of the title compound in a yield of 6%. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 1.11(6H, t), 2.58(2H, m), 3.31(4H, q), 3.35(2H, t), 3.65(2H, s), 3.79(2H, t), 6.65(2H, d), 7.16(2H, d), 7.32(1H, d), 7.44(1H, d), 7.75(1H, s) ESI MS(m/e) = 442 [M+l] Example 74. Synthesis of 2~(3-chIoro-4-ethoxyphenyl)-N-[5-(l,l-dioxo-lλ 6 - isothiazolidin-2-yl)-lH-indazol-3-yI]acetamide(74) 47mg of the title compound was obtained in a yield of 81% according to the same procedure as Example 2, except that 3-chloro-4-ethoxyphenylacetyl chloride was used instead of 3-chlorophenylacetyl chloride. Η NMR (DMSO-d 5 , ppm): δ 1.35(3H, t), 2.40(2H, m), 3.46(2H, t), 3.67(2H, s), 3.68(2H, t), 4.10(2H, q), 7.11(1H, d), 7.35(1H, d), 7.43(1H, s), 7.46(2H, d), 7.55(1H, s), 10.59(1H, s) ESI MS(m/e) = 449 [M+l] Example 75. Synthesis of 2-[4-(2-aminoethoxy)phenyl]-N-[5-(l,l-dioxo-lλ 6 - isothiazolidin-2-yl)-lH-indazol-3-yl]acetamide(75) 75-1) Synthesis of benzyl 2-hydroxyethylcarbamate 944mg(15.46mmol) of 2-aminoethanol was dissolved in 50ml of dichloromethane, and then 1.8ml(12.88mmol) of benzyl chloroformate and 2.7ml(19.32mmol) of triethylamine were added thereto. After the reaction was completed, the mixture was concentrated and 50ml of water was added to obtain a white solid. The obtained white solid was filtered and dried to give 1.94g(9.93mmol) of the title compound in a yield of 77%. Η NMR (CDCI 3 , ppm): δ 3.34(2H, t), 3.71(2H, t), 5.10(2H, s), 7.35-7.39(5H, m) FAB MS(m/e) = 196 [M+l] 75-2) Synthesis of methyl 2-[4-(2-[(benzyloxy)carbonyl]aminoethoxy)phenyl]- acetate 950mg(4.87mmol) of the compound obtained in Example 75-1 and 809mg(4.87mmol) of 4-hydroxyphenylacetic acid methyl ester were dissolved in 70ml of tetrahydrofuran, and then 0.84ml(5.35mmol) of diethylazodicarboxylate and 1.4g(5.35mmol) of triphenylphosphine were added thereto. The mixture was stirred at room temperature for one hour. After the reaction was completed, the solvent was removed under reduced pressure. Addition of 40ml of diethyl ether to the residue caused precipitation. The mixture was stirred for 30 minutes and filtered. The filtrate was purified by silica gel column chromatography to give 1.28g(3.73mmol) of the title compound in a yield of 77%. Η NMR (CDC1 3 , ppm): δ 3.54(3H, s), 3.59(2H, t), 3.67(2H, s), 4.01(2H, t), 5.10(2H, s), 6.82(2H, d), 7.17(2H, d), 7.35-7.39(5H, m) FAB MS(m/e) = 344 [M+l] 75-3) Synthesis of 2-[4-(2-[(benzyloxy)carbonyl]aminoethoxy)phenyl]acetic acid 1.27g(3.70mmol) of the compound obtained in Example 75-2 was dissolved in a solution consisting of 30ml of tetrahydrofuran, 10ml of methanol and 10ml of water, and then 233mg(5.55mmol) of lithium hydroxide was added thereto. The mixture was stirred at room temperature for 15 hours. After the reaction was completed, the mixture was concentrated and 70ml of water was added thereto. The mixture was adjusted to pH of 3 with aqueous IN hydrochloric acid solution to obtain a white solid. The solid thus obtained was filtered, washed with water and dried to give 730mg(2.22mmol) of the title compound in a yield of 60%. Η NMR (CD 3 OD, ppm): δ 3.60(2H, t), 3.71(2H, s), 4.05(2H, t), 5.10(2H, s), 6.82(2H, d), 7.17(2H, d), 7.35-7.39(5H, m) FAB MS(m/e) = 330 [M+l] 75-4) Synthesis of benzyl 3-(2-[4-(2-[(benzyloxy)carbonyl]aminoethoxy)phenyl]- acetylamino)-5-( 1 , 1 -dioxo- 1 λ°-isothiazolidin-2-yl)- lH-indazol- 1 -carboxylate 127mg(0.386mmol) of the compound obtained in Example 75-3 was dissolved in 20ml of dichloromethane, and then 0.001ml of N,N-dimethylformamide and 0.05ml(0.685mmol) of thionyl chloride were added thereto. The mixture was stirred at room temperature for one hour. After the reaction was completed, the mixture was concentrated and dissolved in 20ml of tetrahydrofuran. 99mg(0.257mmol) of the compound obtained in Preparation 1 was added thereto, and the produced mixture was heated to reflux for 2 hours. After the reaction was completed, 30ml of water was added and the mixture was extracted with 20ml of ethyl acetate. After removal of the solvent, concentrated, the residue was purified by silica gel column chromatography to give 170mg(0.243mmol) of the title compound in a yield of 95%. Η NMR (CDC1 3 , ppm): δ 2.53(2H, t), 3.39(2H, t), 3.60(2H, t), 3.71(2H, s), 3.83(2H, t), 4.05(2H, t) 5.11(2H, s), 5.47(2H, s), 6.85(2H, d), 7.20(2H, d), 7.31-7.40(1 OH, m), 7.38-7.40(2H, m), 7.66(1H, d), 8.11(1H, s) FAB MS(m/e) = 698 [M+l] 75-5) Synthesis of 2-[4-(2-aminoethoxy)phenyl]-N-[5-(l,l-dioxo-lλ°-isothiazoli- din-2-yl)- lH-indazol-3 -yl] acetamide 82mg(0.118mmol) of the compound obtained in Example 75-4 was dissolved in a solution of 20ml methanol and 10ml of dichloromethane, and catalytic amount of palladium-adsorbed activated carbon(10%) was added thereto. The mixture was stirred under hydrogen atmosphere for 2 hours. After the reaction was completed, the product was filtered through celite. The removal of solvent under reduced pressur gave 32mg(0.075mmol) of the title compound in a yield of 63%. Η NMR (CD 3 OD, ppm): δ 2.50(2H, t), 3.30(2H, t), 3.34(2H, t), 3.43(2H, t), 3.78(2H, s), 4.05(2H, t), 6.95(2H, d), 7.34(2H, d), 7.40-7.52(2H, m), 7.66(1H, d) FAB MS(m e) = 430 [M+l] Example 76. Synthesis of 2-[2-(acetylamino)-l,3-thiazoI-4-yl]-N-[5-(l,l-dioxo- lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl] acetamide(76) After 40mg(0.102mmol) of the compound obtained in Example 60 was dissolved in 5ml of N,N-dimethylformamide, were added 0.01ml(1.5eq) of acetic acid, 33mg(1.7eq) of l-(3~dimethylaminopropyl)-3-ethylcarbodiimide hydrochloric acid salt and 32mg(2.3eq) of hydroxybenzotriazole. The mixture was stirred for 12 hours. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 93/7(v/v)) to give 5mg of the title compound in a yield of 11%. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 2.53(2H, m), 2.66(3H, s), 3.42(2H, t), 3.67(2H, s), 3.83(2H, t), 6.35QH, s), 7.52(1H, dd), 7.84(1H, s), 8.32(1H, d) ESI MS(m/e) = 435 [M+l] Example 77. Synthesis of 2-(2-[4-(benzyloxy)benzyl]amino-l,3-thiazol-4-yι)-N~ [5-(l,l-dioxo-lλ 6 -isothiazoIidin-2-yI)-lH-indazol-3-yl]acetamide(77) 77-1) Synthesis of 2-[2-([4-(benzyloxy)phenyl]methylideneamino)-l,3-thiazol-4- yl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]acetamide After 50mg(0.128mmol) of the compound obtained in Example 60 was dissolved in 8ml of N,N-dimethylformamide, were added 81mg(3.0eq) of 4-benzyloxybenzaldehyde, 0.1g(4eq) of sodium triacetoxyborohydride and 0.4ml(5eq) of acetic acid. The mixture was stirred for 12 hours. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 93/7(v/v)) to give 20mg of the title compound in a yield of 26%. Η NMR (CDCI 3 + CD 3 OD, ppm): δ 2.16(2H, m), 3.03(2H, t), 3.49(2H, t), 3.64(2H, s), 4.87(2H, s), 6.79(1H, d), 6.91(1H, s), 7.11(6H, m), 7.40(1H, s), 7.64(1H, d), 8.59(1H, s) API MS(m/e) = 587 [M+l] 77-2) Synthesis of 2-(2-[4-(benzyloxy)benzyl]amino-l,3-thiazol-4-yl)-N-[5-(l,l- dioxo- 1 λ 6 -isothiazolidin-2-y 1)- 1 H-indazol-3 -yl] acetamide 20mg(0.034mmol) of the compound obtained in Example 77-1 was dissolved in 20ml of methanol, and then 60mg of sodium borohydride was added thereto. After stirring 3.5 hours, the solvent was removed under reduced pressure. Filtration of the precipitate caused by removal of solvent gave the title compound quantatively. Η NMR (CDC1 3 + CD 3 OD, ppm): δ 2.45(2H, m), 3.35(2H, t), 3.68(2H, s), 3.75(2H, t), 4.08(2H, m), 4.40(2H s), 4.94(2H, s), 6.38(1H, s), 6.83(2H, d), 7.25(3H, m), 7.32(2H, m), 7.36(2H, m), 7.44(2H, m), 7.66(1H, s) API MS(m/e) = 589 [M+l] Example 78. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-(3-ethoxyphenyl)acetamide(78) 40mg of the title compound was obtained in a yield of 48% according to the same procedure as Example 2, except that 3-ethoxyphenylacetyl chloride was used instead of 3- chlorophenylacetyl chloride. Η NMR (DMSO-d 6 , ppm): δ 1.32(3H, t), 2.40(2H, m), 3.46(2H, t), 3.68(4H, m), 4.03(2H, q), 6.81(1H, d), 6.94(1H, d), 6.95(1H, s), 7.24QH, t), 7.35(1H, d), 7.46(1H, d), 7.55(1H, s), 10.59(1H, s) ESI MS(m/e) = 415 [M+l] Example 79. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yI]-2-[4-ethoxy-3-(4-morphoIinyIsulfonyl)phenyl]acetamide(79) 79-1) Synthesis of ethyl 2-[3-(chlorosulfonyl)-4-ethoxyphenyl]acetate After addition of 208mg(1.0mmol) of ethyl 2-(4-ethoxyphenyl)acetate to 0.2ml(3.0mmol) of chlorosulfuric acid dropwise at 0 ° C, the mixture was warmed to room temperature and stirred for one hour, and then poured into ice water. After the resultant was extracted with ethyl acetate, the extracted ethyl acetate solution was washed with water three times. The solvent was removed under reduced pressure to give llOmg of the title compound in a yield of 34%. Η NMR (CDC1 3 , ppm): δ 1.26(3H, t), 1.53(3H, t), 3.60(2H, s), 4.16(2H, q), 4.27(2H, q), 7.05(1H, d), 7.58(1H, d), 7.84(1H, s) 79-2) Synthesis of ethyl 2-[4-ethoxy-3-(4-morpholinylsulfonyl)phenyl]acetate 107mg(0.35mmol) of the compound obtained in Example 79-1 was dissolved in dichloromethane, and then 61mg(0.7mmol) of morpholine and 71mg(0.7mmol) of triethylamine were added thereto. The mixture was stirred for one hour. The solvent was removed under reduced pressure. After the residue was extracted with ethyl acetate, the extracted ethyl acetate solution was washed with water three times. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = l/l(v/v)) to give 106mg of the title compound in a yield of 85%. Η NMR (CDC1 3 , ppm): δ 1.24(3H, t), 1.46(3H, t), 3.24(4H, t), 3.57(2H, s), 3.71(4H, t), 4.14(4H, q), 6.95(1H, d), 7.42(1H, d), 7.77(1H, s) ESI MS(m/e) = 358 [M+l] 79-3) Synthesis of ethyl 2-[4-ethoxy-3-(4-morpholinylsulfonyl)phenyl]acetic acid 103mg(0.288mmol) of the compound obtained in Example 79-2 was dissolved in a solution of 3ml of tetrahydrofuran/ lml of methano/lml of water, and then 35mg(0.864mmol) of lithium hydroxide was added thereto. The mixture was stirred at room temperature for one hour. After the solvent was removed under reduced pressure, aqueous IN HC1 solution was added thereto to adjust to pH of 3. After the resulting mixture was extracted with ethyl acetate, the extracted ethyl acetate solution was washed with water three times. The solvent was removed under reduced pressure to give 94mg of the title compound in a yield of 99%. Η NMR (CDC1 3 , ppm): δ 1.45(3H, t), 3.24(4H, t), 3.61(2H, s), 3.70(4H, t), 4.14(2H, q), 6.96(1H, d), 7.42(1H, d), 7.76(1H, s) ESI MS(m e) = 330 [M+l] 79-4) Synthesis of ethyl 2- [4-ethoxy-3-(4-morpholinylsulfonyl)phenyl] acetyl chloride 94mg(0.28mmol) of the compound obtained in Example 79-3 was dissolved in dichloromethane, and then 100mg(0.84mmol) of thionyl chloride was added thereto. The mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure to give the title compound quantatively. 79-5) Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4- ethoxy-3 -(4-morpholinylsulfonyl)phenyl]acetamide 80mg of the title compound was obtained in a yield of 70% according to the same procedure as Example 2, except that the compound obtained in Example 97-4 was used instead of 3-chlorophenylacetyl chloride. Η NMR (DMSO-d 6 , ppm): δ 1.36(3H, t), 2.39(2H, m), 3.09(4H, t), 3.46(2H, t), 3.59(4H, t), 3.68(2H, t), 3.74(2H, s), 4.16(2H, q), 7.24(1H, d), 7.35(1H, d), 7.46(1H, d), 7.54(1H, s), 7.62(1H, d), 7.79(1H, s), 10.66(1H, s) ESI MS(m/e) = 564 [M+l] Example 80. Synthesis of 2-[3-(aminosuIfonyl)-4-ethoxyphenyl]-N-[5-(l,l-di- oxo-lλ 6 -isothiazolidin-2-yI)-lH-indazol-3-yI] acetamide(80) 80-1) Synthesis of 5-(2-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3- yl]amino-2-oxoethyl)-2-ethoxybenzenesulfonyl chloride 20mg(0.048mmol) of the compound obtained in Example 42 was added to 0.2ml of chlorosulfuric acid dropwise at 0 ° C . After stirring for 10 minutes, the mixture was poured into ice water. The resultant was extracted with ethyl acetate, and then the extracted ethyl acetate solution was washed with water three times. The solvent was removed by evaporation under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: ethyl acetate) to give 3mg of the title compound in a yield of 12%. ! H NMR (DMSO-d s , ppm): δ 1.30(3H, t), 2.39(2H, m), 3.45(2H, t), 3.68(2H, t), 3.72(2H, s), 4.02(2H, q), 6.93(2H, d), 7.28(1H, d), 7.35(1H, d), 7.45QH, d), 7.49(1H, s), 7.76(1H, s), 10.61(1H, s) 80-2) Synthesis of 2-[3-(aminosulfonyl)-4-ethoxyphenyl]-N-[5-(l,l-dioxo-lλ 6 -iso- thiazolidin-2-yl)-lH-indazol-3-yl]acetamide 10mg(0.019mmol) of the compound obtained in Example 80-1 was dissolved in 5ml of acetonitrile, and then 0.1ml of ammonia water was added thereto. The mixture was stirred for 2 hours. The resultant was extracted with ethyl acetate, and then the extracted ethyl acetate solution was washed with water three times. After the solvent was removed by evaporation under reduced pressure, the residue was treated with diethyl ether to give 5mg of the title compound as a solid in a yield of 56%. Η NMR (DMSO-d 6 , ppm): δ 1.37(3H, t), 2.39(2H, m), 3.45(2H, t), 3.68(2H, t), 3.72(2H, s), 4.20(2H, q), 6.90(2H, s), 7.19(1H, d), 7.35(1H, d), 7.46(1H, d), 7.54(1H, d), 7.55(1H, s), 7.80(1H, s), 10.67(1H, s) ESI MS(m/e) = 494 [M+l] Example 81. Synthesis of N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3-yl]-2-4-ethoxy-3-[(4-methyl-l-piperazinyl)sulfonyl]phenylacetamide(81) 7mg(0.014mmol) of the compound obtained in Example 80-1 was dissolved in 5ml of dichloromethane, and then 0.1ml of N-methylpiperazine was added thereto. The mixture was stirred for 15 hours. The resultant was extracted with ethyl acetate, and then the extracted ethyl acetate solution was washed with water three times. After the solvent was removed by evaporation under reduced pressure, the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 9:1) to give 2mg of the title compound in a yield of 25%. Η NMR (CDC1 3 , ppm): δ 1.42(3H, t), 2.28(3H, s), 2.44(4H, br), 2.49(2H, m), 3.28(4H, br), 3.39(2H, t), 3.72(2H, s), 3.74(2H, t), 4.05(2H, q), 6.90(1H, d), 7.19(1H, d), 7.38(1H, d), 7.47(1H, d), 7.57(1H s), 7.89(1H, s), 8.66(1H, s) ESI MS(m e) = 577 [M+l] Example 82. Synthesis of 2-[4-(2-aminoethoxy)phenyl]-N-[5-(l,l-dioxo-lλ 6 - isothiazolidin-2-yl)-lH-indazol-3-yI] acetamide (82) 82-1) Synthesis of benzyl 2-hydroxyethylcarbamate 944mg(15.46mmol) of 2-aminoethanol was dissolved in 50ml of dichloromethane, and then 1.8ml(12.88mmol) of benzyl chloroformate and 2.7ml(19.32mmol) of triethylamine were added thereto. The mixture was stirred at room temperature for one hour. After the reaction was completed, the mixture was concentrated and 50ml of water was added thereto to obtain a white solid. The obtained white solid was filtered and dried to give 1.94g(9.93mmol) of the title compound in a yield of 77%. Η NMR (CDC1 3 , ppm): δ 3.34(2H, t), 3.71(2H, t), 5.10(2H, s), 7.35-7.39(5H, m) FAB MS(m/e) = 196 [M+l] 82-2) Synthesis of methyl 2-[4-(2-[(benzyloxy)carbonyl]aminoethoxy)phenyl]- acetate 950mg(4.87mmoι) of the compound obtained in Example 82-1 and 809mg(4.87mmol) of 4-hydroxyphenylacetic acid methyl ester were dissolved in 70ml of tetrahydrofuran, and then 0.84ml(5.35mmol) of diethylazodicarboxylate and 1.4g(5.35mmol) of triphenylphosphine were added thereto. The mixture was stirred at room temperature for one hour. After the reaction was completed, the mixture was concentrated and 40ml of diethyl ether was added thereto. The mixture was stirred for 30 minutes and the obtained precipitate was filtered. The filtrate was purified by silica gel column chromatography to give 1.28g(3.73mmol) of the title compound in a yield of 77%. Η NMR (CDCI 3 , ppm): δ 3.54(3H, s), 3.59(2H, t), 3.67(2H, s), 4.01(2H, t), 5.10(2H, s), 6.82(2H, d), 7.17(2H, d), 7.35-7.39(5H, m) FAB MS(m/e) = 344 [M+l] 82-3) Synthesis of 2-[4-(2-[(benzyloxy)carbonyl]aminoethoxy)phenyl]acetic acid 1.27g(3.70mmol) of the compound obtained in Example 82-2 was dissolved in a solution consisting of 30ml of tetrahydrofuran, 10ml of methanol and lOml of water, and then 233mg(5.55mmol) of lithium hydroxide was added thereto. The mixture was stirred at room temperature for 15 hours. After the reaction was completed, the mixture was concentrated and 70ml of water was added thereto. The mixture was adjusted to pH of 3 with aqueous IN hydrochloric acid solution to obtain a white solid. The solid thus obtained was filtered, washed with water and dried to give 730mg(2.22mmol) of the title compound in a yield of 60%. Η NMR (CD 3 OD, ppm): δ 3.60(2H, t), 3.71(2H, s), 4.05(2H, t), 5.10(2H, s), 6.82(2H, d), 7.17(2H, d), 7.35-7.39(5H, m) FAB MS(nVe) = 330 [M+l] 82-4) Synthesis of benzyl 3-(2-[4-(2-[(benzyloxy)carbonyl]aminoethoxy)phenyl]- acetylamino)-5-(l , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)-lH-indazol- 1-carboxylate 127mg(0.386mmol) of the compound obtained in Example 82-3 was dissolved in 20ml of dichloromethane, and then 0.001ml of N,N-dimethylformamide and 0.05ml(0.685mmol) of thionyl chloride were added thereto. The mixture was stirred at room temperature for one hour. After the reaction was completed, the mixture was concentrated and the residue was dissolved in 20ml of tetrahydrofuran. 99mg(0.257mmol) of the compound obtained in Preparation 1 was added thereto, and the produced mixture was heated to reflux for 2 hours. After the solvent was removed under reduced pressure, 30ml of water was added thereto and then the mixture was extracted with ethyl acetate. After the solvent was removed under reduced pressure, the residue was purified by silica gel column chromatography to give 170mg(0.243mmol) of the title compound in a yield of 95%. Η NMR (CDCI 3 , ppm): δ 2.53(2H, t), 3.39(2H, t), 3.60(2H, t), 3.71(2H, s), 3.83(2H, t), 4.05(2H, t), 5.11(2H, s), 5.47(2H, s), 6.85(2H, d), 7.20(2H, d), 7.31-7.40(10H, m), 7.38-7.40(2H, m), 7.66QH, d), 8.11(1H, s) FAB MS(m/e) = 698 [M+l] 82-5) Synthesis of 2-[4-(2-aminoethoxy)phenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazoli- din-2-yl)-lH-indazol-3-yl]acetamide 82mg(0.118mmol) of the compound obtained in Example 82-4 was dissolved in a solution of 20ml methanol and 10ml of dichloromethan, and catalytic amount of palladium-adsorbed activated carbon(10%) was added thereto. The mixture was stirred under hydrogen atmosphere for 2 hours. After the reaction was completed, the mixture was filtered through celtite. Removal of solvent under reduced pressure gave 32mg(0.075mmol) of the title compound in a yield of 63%. 'H NMR (CD 3 OD, ppm): δ 2.50(2H, t), 3.30(2H, t), 3.34(2H, t), 3.43(2H, t), 3.78(2H, s), 4.05(2H, t), 6.95(2H, d), 7.34(2H, d), 7.40-7.52(2H, m), 7.66(1H, d) FAB MS(m/e) = 430 [M+l ] Experimental Example: CDK2 and CDK4 Inhibitory Activity Analytical experiments on inhibitory effects for CDK 2 and CDK 4 proteins were performed in accordance with Kitagawa's method(Kitagawa, M. et al.; Oncogene, 9: 2549, 1994) and Carlson's method(Carlson, B. A. et al.; Cancer Research 56: 2473, 1996), respectively. CDK2 enzyme was obtained from either extract from the worm cell co- infected with baculovirus which expresses a CDK2 gene and baculovirus which expresses a cyclin A gene, or active enzyme purified therefrom. CDK4 was also obtained from either extract from the worm cell co-infected with baculovirus which expresses a CDK4 gene and baculovirus which expresses a cyclin DI gene. As substrates, histon HI or Rb protein was used for CDK2, and Rb protein for CDK4. The radioactive activities in substrates were determined by reacting compounds diluted with each concentration with a proper quantity of CDK2/cyclin A or CDK4/cyclin DI and substrate protein, and [gamma- 32P labeled] ATP, and then separating the substrates. Inhibitory abilities of inhibitors according to the present invention for each enzyme activity were expressed as IC50 values, which were determined in accordance with the method as described above. The results are shown in Table 1 below.

Claims: WHAT IS CLAIMED IS: A compound represented by the following formula (1): in which n represents 0, 1, 2 or 3, X represents oxygen, sulfur or nitrogen atom, R 1 and R 2 each independently represent hydrogen, amino, hydroxy, lower alkyl or cycloalkyl, or together form cycloalkyl, R 3 represents hydrogen; lower alkyl; phenyl, benzyl or naphthyl which may be unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, halogen, nitro, amide, ester, carboxy, cyano, amidinyl, -O-R 5 , - NR 6 R 7 , phenyl, alkylsulfanyl, R 8 -SO 2 -, lower alkyl, lower alkyl substituted with R 9 , pyridinyl, piperidinyl, morpholinyl, piperazinyl, thienyl and furyl; aromatic and bicyclic aromatic compounds bearing at least one heteroatom selected from nitrogen, oxygen or sulfur atom; C 3 . 7 -cycloalkyl bearing at least one heteroatom selected from nitrogen, oxygen or sulfur atom; piperazinyl, imidazolyl, morpholinyl or piperidinyl which may be unsubstituted or substituted with one or two substituents selected from the group consisting of lower alkyl, phenyl, phenyl substituted with halogen, phenyl substituted with alkoxy, phenyl substituted with alkylcarbonyl, biphenyl and naphthyl; thiazole which may be unsubstituted or substituted with amino, mono- or di- lower alkylamino, alkylcarbonylamino, benzylamino, benzyloxycarbonylamino, benzyloxybenzylamino or alkoxycarbonylamino; benzodioxol; isoquinoline; indolyl; or benzimidazole wherein R 5 represents phenyl, benzyl, lower alkyl, alkoxyalkyl, alkoxyalkoxylalkyl, alkoxyalkoxyalkoxyalkyl, aminoalkyl or mono- or di-alkylaminoalkyl, R 6 and R 7 are identifical or different from each other and represent hydrogen, lower alkyl, oxygen or benzyl, or joined to form a ring, and R s and R 9 represent each independently lower alkyl, amino, morpholinyl, piperazinyl, N-alkylpiperazinyl or imidazolyl, and R 4 represents nothing when X is oxygen or sulfur atom, but represents hydroxy or alkoxy when X is nitrogen atom, pharmaceutically acceptable salt, solvated product or isomer thereof. 2. The compound of formula (1), or pharmaceutically acceptable salt, solvated product or isomer thereof according to claim 1, wherein n represents 1 or 2, X represents oxygen, sulfur or nitrogen atom, R 1 and R 2 each independently represent hydrogen, amino, hydroxy, lower alkyl or cycloalkyl, or together form cycloalkyl, R 3 represents hydrogen; lower alkyl; phenyl which may be unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, halogen, nitro, amide, cyano, amidinyl, -O-R 5 , -NR°R 7 , phenyl, lower alkylsulfanyl, R s - SO 2 -, lower alkyl, lower alkyl substituted with R 9 , pyridiny, piperidinyl, morpholinyl, thienyl and furyl; naphthyl; piperazinyl or imidazolyl which may be unsubstituted or substituted with one or two substituents selected from the group consisting of lower alkyl, phenyl, phenyl substituted with halogen, phenyl substituted with lower alkoxy, phenyl substituted with acetyl, biphenyl and naphthyl; morpholinyl; piperidinyl; thiazole which may be unsubstituted or substituted with amino, mono- or di- lower alkylamino, acetylamino, benzylamino, benzyloxyamino, benzyloxybenzylamino or lower alkoxycarbonylamino; benzodioxol; 3,4-dihydroisoquinoline; or benzimidazole wherein R 5 represents phenyl, benzyl, lower alkyl, lower alkoxyalkyl, polyethyleneglycolyl, aminoalkyl or mono- or di- lower alkylaminoalkyl, R 6 and R 7 are identifical or different from each other and represent hydrogen, lower alkyl, oxygen or benzyl, or joined to form a ring, and R 8 and R 9 each independently represent lower alkyl, amino, morpholinyl, piperazinyl, N-alkylpiperazinyl or imidazolyl, and R 4 represents nothing when X is oxygen or sulfur atom, but represents hydroxy or alkoxy when X is nitrogen atom. 3. The compound of formula (1), or pharmaceutically acceptable salt, solvated product or isomer thereof according to claim 1 wherein the compound is selected from the group consisting of 1. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-phenylacetamide, 2. 2-(3-chlorophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]- acetamide, 3. 2-[4-(benzyloxy)phenyl]-N-[5-(l, 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol- 3 -yl] acetamide, 4. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-hydroxy-phen- yl)acetamide, 5. 2-[4-(dibenzylamino)phenyl]-N-[5-(l , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-ind- azol-3 -yl]acetamide, 6. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(methylamino)- phenyl] acetamide, 7. 2-(4-aminophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]- acetamide, 8. 2-(4-chlorophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]- acetamide, 9. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-fluorophenyl)- acetamide, 10. 2- [ 1 , 1 '-biphenyl] -4-yl-N- [5 -( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 - yl] acetamide, 11. 2-(3 -bromophenyl)-N-[5 -( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]- acetamide, 12. 2-(4-bromophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]- acetamide, 13. N-[5-(l, l-dioxo-lλ 5 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-ρhenylethanethio- amide, 14. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-N'-hydroxy-2-phen- ylethaneimidoamide, 15. 2-(l,3-benzodioxol-5-yl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol- 3 -yl] acetamide, 16. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-( 1 -naphthyl)acet- amide, 17. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(2-naphthyl)acet- amide, 18. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-(3 -nitrophenyl)ac- etamide, 19. N-[5-(l,l -dioxo- 1 λ 6 -isothiazolidin-2-yl)- 1 H-indazol-3 -yl] acetamide, 20. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(methylsulfan- yl)phenyl] acetamide, 21. 2-(3-aminophenyl)-N-[5-(l, 1 -dioxo- lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]- acetamide, 22. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]ethanethioamide, 23. N-[5-(l,l-dioxo-lλ 5 -isothiazolidin-2-yl)-lH-indazol-3-yl]-N'-hydroxyethane- imidoamide, 24. 2-(3,4-dichlorophenyl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3- yl] acetamide, 25. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-3 -phenylpropanami- e, 26. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-isopropylphen- yl)acetamide, 27. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(3-methylphenyl)- acetamide, 28. N-[5-(l,l-dioxo-lλ 5 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-methylρhenyl)- acetamide, 29. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(methylsulfon- yl)phenyl]acetamide, 30. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-methyl-l-pipe- razinyl)acetamide, 31. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-morpholinyl)- acetamide, 32. N- [5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- 1 H-indazol-3 -yl] -2-( 1 -piperidinyl)- acetamide, 33. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-pyridinyl)- phenyl] acetamide, 34. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(l-piperidin- yl)phenyl] acetamide, 35. N-[5-(l,l-dioxo-lλ s -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(l-morpholin- yl)-phenyl]acetamide, 36. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(3-thienyl)ph- enyl] acetamide, 37. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-morpholin- ylsulfonyl)phenyl]acetamide, 38. N-[5-(l, 1-dioxo-l λ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-methoxyphen- yl)acetamide, 39. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(2-furyl)phen- yl] acetamide, 40. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-4-[(4-methyl-l- piperazinyl)sulfonyl]phenylacetamide, 41. 2-(lH-benzimidazol-l-yl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indaz- ol-3 -yl] acetamide, 42. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-ethoxyρhenyl)- acetamide, 43. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-morpholin- ylmethyl)phenyl]acetamide, 44. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-4-[(4-methyl-l- piperazinyl)methyl]phenylacetamide, 45. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-nitroρhenyl)- acetamide, 46. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(lH-imidazol- 1 -ylmethyl)phenyl]acetamide, 47. N-[5-(l,l-dioxo-lλ δ -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-phenyl-lH-im- idazol- 1 -yl)acetamide, 48. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-phenyl-l-piρe- razinyl)acetamide, 49. 2-[3,4-dihydro-2(lH)-isoquinolinyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]acetamide, 50. N-[5-(l,l-dioxo-lλ 5 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-chlorophen- yl)-l -piperazinyljacetamide, 51. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(4-methoxyph- enyl)- 1 -piperazinyl] acetamide, 52. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(2-ethoxyphen- yl)- 1 -piperazinyl] acetamide, 53. 2-[4-(4-acetylphenyl)- 1 -piperazinyl]-N-[5-(l , 1-dioxo- 1 λ°-isothiazolidin-2-yl)- 1 H-indazol-3 -yl] acetamide, 54. N-[5-(l,l-dioxo-lλ e -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-phenoxyphen- yl)acetamide, 55. N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]- 1 -phenylcyclopen- tanecarboxamide, 56. 2-cycloρentyl-N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3 -yl]-2-ρh- enylacetamide, 57. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-phenylbutanami- de, 58. t-butyl 4-(2- [5-(l , 1 -dioxo- 1 λ 0 -isothiazolidin-2-yl)- lH-indazol-3 -yl] amino-2- oxoethyl)-l,3-thiazol-2-ylcarbamate, 59. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-4-[2-(2-ethoxy- ethoxy)ethoxy]phenylacetamide, 60. 2-(2-amino- 1 ,3 -thiazol-4-yl)-N-[5-( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-in- dazol-3 -yl] acetamide, 61. 2-[4-(4-bromophenyl)-lH-imidazol-l-yl]-N-[5-(l, 1 -dioxo- lλ°-isothiazolidin- 2-yl)-lH-indazol-3-yl]acetamide, 62. N- [5 -( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- 1 H-indazol-3 -yl] -2- [4-(2-naphthy 1)- lH-imidazol-l-yl]acetamide, 63. 2-(4-[l,r-biphenyl]-4-yl-lH-imidazol-l-yl)-N-[5-(l,l-dioxo-lλ 6 -isothiazolid- in-2-yl)-l H-indazol-3 -yl] acetamide, 64. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[2-(ethylamino)- 1 , 3 -thiazol-4-yl] acetamide, 65. 2-[2-(diethylamino)- 1 ,3-thiazol-4-yl]-N-[5-(l , 1-dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]acetamide, 66. N-[5-(l, l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-2-[2-(2-meth- oxyethoxy)ethoxy]ethoxyphenyl)acetamide, 67. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(4-ethoxy-3-nitro- phenyl)acetamide, 68. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(2-methylphenyl)- acetamide, 69. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[3-(ethylamino)- phenyl] acetamide, 70. 2-[3-(diethylamino)phenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-inda- zol-3 -yl]acetamide, 71. 2-(3 , 5-dimethoxyphenyl)-N-[5-(l , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol- 3-yl]acetamide, 72. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-(ethylamino)- pheny 1] acetamide, 73. 2-[4-(diethylamino)phenyl]-N-[5-(l , 1-dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-inda- zol-3-yl] acetamide, 74. 2-(3 -chloro-4-ethoxyphenyl)-N- [5 -( 1 , 1 -dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-ind- azol-3 -yl] acetamide, 75. 2-[4-(2-aminoethoxy)phenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-ind- azol-3 -yl] acetamide, 76. 2-[2-(acetylamino)-l,3-thiazol-4-yl]-N-[5-(l, 1 -dioxo- lλ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]acetamide, 77. 2-(2-[4-(benzyloxy)benzyl]amino-l,3-thiazol-4-yl)-N-[5-(l,l-dioxo-lλ 6 -isothi- azolidin-2-yl)- 1 H-indazol-3 -yl] acetamide, 78. N-[5-(l, 1 -dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-(3-ethoxyphenyl)- acetamide, 79. N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH-indazol-3-yl]-2-[4-ethoxy-3-(4- morpholinylsulfonyl)phenyl]acetamide, 80. 2-[3-(aminosulfonyl)-4-ethoxyphenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2- yl)-lH-indazol-3-yl]acetamide, 81. N-[5-(l, 1-dioxo- 1 λ 6 -isothiazolidin-2-yl)- lH-indazol-3-yl]-2-4-ethoxy-3-[(4- methyl- 1 -piperazinyl)sulfonyl]phenylacetamide, and 82. 2-[4-(2-aminoethoxy)phenyl]-N-[5-(l,l-dioxo-lλ 6 -isothiazolidin-2-yl)-lH- indazol-3-yl]acetamide. 4. A composition of anti-cancer agent comprising the compound of formula (1), or pharmaceutically acceptable salt, solvated product or isomer thereof as defined in claim 1 as an active ingredient together with a pharmaceutically acceptable carrier. 5. A process for preparing the compound of formula (1), or pharmaceutically acceptable salt, solvated product or isomer thereof as defined in claim 1 which comprises a) reacting anthranilonitrile with hydroxylamine to produce an amidoxime of the following formula (2): b) reacting the amidoxime with ester to produce a 3-aminoindazole of the following formula (3): wherein R , R , R and n are as defined in claim 1, c) protecting the 1 -position of 3-aminoindazole by t-butylcarbamate to produce a compound of the following formula (4): wherein R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl. d) reducing the nitro group at C-5 of formula (4) to produce an amine of the following formula (5): wherein, R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl. e) reacting the amine of formula (5) with sulfonyl chloride to produce a sulfonamide of the following formula (6): J wherein, R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl. e) cyclizing the compound of formula (6) through intramolecular ring-closing to synthesize a dioxoisothiazolidine of the following formula (7): wherein R 1 , R 2 , R 3 and n are as previously described, and Boc represents t- butoxycarbonyl, and f) deprotecting the compound of formula (7). 6. The process for preparing the compound of formula (1), or pharmaceutically acceptable salt, solvated product or isomer thereof according to claim 5 which comprises a) reacting a compound of formula (1) wherein X is oxygen atom with Lawesson's reagent to produce a compound of formula (1) wherein X is sulfur atom; or b) reacting the compound of formula (1) wherein X is sulfur atom with a compound of the following formula (8): R 4 -NH 2 (8) wherein R 4 is as defined in claim 1, to produce a compound of formula (1) wherein X is nitrogen atom. 7. A process for preparing the compound of formula (1), or pharmaceutically acceptable salt, solvated product or isomer thereof which compises reacting an indazole intermediate of the following formula (9): wherein Cbz represents benzyloxycarbonyl, with an acyl halide of the following formula (10): wherein R 1 , R 2 , R 3 and n are as defined in claim 1, and X' represents halogen. 8. A compound of formula (9): wherein Cbz represents benzyloxycarbonyl, as an intermediate for preparing the compound of formula (1), or pharmaceutically acceptable salt, solvated product or isomer thereof as defined in claim 1.

Inventors: CHOI SEI HYUN, CHUNG HYUN HO, HONG CHANG YONG, HWANG KWANG YEON, JEONG SHIN WU, KIM JONG HYUN, LEE JIN HO, PARK TAE SIK, SHIN DONG KYU, YOON SOOK KYUNG, CHOI, SEI, HYUN, CHUNG, HYUN, HO, HONG, CHANG, YONG, HWANG, KWANG, YEON, JEONG, SHIN, WU, KIM, JONG, HYUN, LEE, JIN, HO, PARK, TAE, SIK, SHIN, DONG, KYU, YOON, SOOK, KYUNG
Applicants: CHOI SEI HYUN, CHUNG HYUN HO, HONG CHANG YONG, HWANG KWANG YEON, JEONG SHIN WU, KIM JONG HYUN, LEE JIN HO, LG CHEM INVEST LTD, PARK TAE SIK, SHIN DONG KYU, YOON SOOK KYUNG, CHOI, SEI, HYUN, CHUNG, HYUN, HO, HONG, CHANG, YONG, HWANG, KWANG, YEON, JEONG, SHIN, WU, KIM, JONG, HYUN, LEE, JIN, HO, LG CHEM INVESTMENT LTD., PARK, TAE, SIK, SHIN, DONG, KYU, YOON, SOOK, KYUNG
Application year: 2001
Main classification: C07D417
IPC codes: A61K31, A61P9, A61P29, A61P35, A61P43, C07D417