N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS

Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

Description: N-ACYLSULFONA DE APOPTOSIS PROMOTERS Technical Field The present invention relates to substituted N-acylsulfonamides which are useful for promoting apoptosis, methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. Background of the Invention Apoptosis is a mode of cell death in which the cell commits suicide either to ensure proper development of the organism or to destroy cells that represent a threat to the organism's integrity. Morphologically, apoptosis is characterized by blebbing of the plasma membrane, shrinking of the cytoplasm and nucleus, and fragmenting into particles which are engulfed by phagocytic cells. Although apoptosis plays a critical role in normal development, its impairment is thought to be a significant factor in the etiology of such diseases as cancer, autoimmune disorders, inflammatoiy diseases, and viral infections. Conversely, increased apoptosis has been linked to AIDS and neurodegenerative diseases such as Parkinson's disease, stroke, and Alzheimer's disease. BCL-Xl is a protein which, in healthy cells, is expressed in the outer membranes of the mitochondria, the endoplasmic reticulum, and the nuclear envelope. Its function is to bind to specific protein/protease complexes and prevent cell apoptosis. Upon internal damage to the cell the protein/protease complexes are released, and cause the process of apoptosis to begin. An over-expression of BCL-Xl, often present in cancerous and other diseased cells, results in the blocking of apoptotic signals and allows the cells to proliferate (Cancer 1999, 85, 164-170; and references cited therein). It is believed that by blocking BCL-Xl, apoptosis can be induced in diseased cells, and can provide an effective therapy for cancer and other diseases caused by the impairment of the apoptotic process. Based on these findings and the absence of BCL-Xl inhibitors from current cancer therapies, there is a continuing need for compounds which can trigger apoptosis through the inhibition of the BCL family of proteins. Summary of the Invention In its principle embo a compound of formula (I) CO, or a therapeutically acceptable salt thereof, wherein A is selected from the group consisting of phenyl and a five- or six-membered aromatic carbocyclic ring wherein from one to three carbon atoms are replaced by a heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur, and wherein A is substituted through carbon atoms in the ring; R is selected from the group consisting of alkyl, haloalkyl, nitro, and -NR 5 R 6 ; R , and R are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkyl, alkylsulfanyl, alkynyl, aryl, arylalkoxy, aryloxy, aryloxyalkoxy, arylsulfanyl, arylsulfanylalkoxy, carbonyloxy, cycloalkylalkoxy, cycloalkyloxy, halo, haloalkoxy, haloalkyl, heterocycle, (heterocycle)oxy, hydroxy, nitro, and -NR 5 R 6 , R is selected from the group consisting of aryl, arylalkenyl, arylalkoxy, cycloalkenyl, cycloalkyl, halo, heterocycle, and (heterocycle)alkoxy; R and R are independently selected from the group consisting of hydrogen, alkenyl, alkoxyalkyl, alkoxycarbonylalkyl, alkyl, alkylsulfanylalkyl, alkylsulfonylalkyl, aryl, arylalkyl, arylalkylsulfanylalkyl, aryloxyalkyl, arylsulfanylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, carboxyalkyl, cycloalkenyl, cycloalkenylalkyl, cycloalkyl, (cycloalkyι)alkyl, cycloalkylcarbonyl, heterocycle, (heterocycle)alkyl, 7 8 (heterocycle)sulfanylalkyl, hydroxyalkyl, a nitrogen protecting group, and -N=CR R ; or R and R , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of imidazolyl, morpholinyl, piperazinyl, piperidinyl, pyrrolidinyl, pyrrolyl, thiomorphoHnyl, and thiomorpholinyl dioxide; and 7 8 R and R are alkyl, or 7 8 R and R , together with the carbon atom to which they are attached, form an aryl group; and 15 R is selected from the group consisting of hydrogen, alkyl, and halo. In another embodiment the present invention provides a compound of formula (I) 1 8 wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; and R -R 15 and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected 1 2. 4-8 from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; and R , R , R " , and R 15 are as previously defined. In another embodiment the present invention provides a compound of formula (I) 3 wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is selected from the group consisting of arylsulfanylalkoxy, cycloalkylalkoxy, and cycloalkyloxy; and R , R , and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; and R , R , R , R , and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R 2 is -NR R ; one of R and R is selected from the group consisting of alkyl, aryl, arylalkyl, arylalkylsulfanylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, cycloalkylcarbonyl, heterocycle, 7 8 (heterocycle)alkyl, heterocyclesulfanylalkyl, and -N=CR R ; and the other is hydrogen; and R 1 , R4 , R 7 , R 8 , and R 15 are as previously defined. In another embodiment the present invention provides a compound of formula (I) 3 wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; one of R and R is (cycloalkyl)alkyl and the other is arylsulfanylalkyl; and R , R , and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R" is -NR R ; one of R and R is cycloalkyl and the other is hydrogen; and R , R , and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; one of R and R is (cycloalkyl)alkyl and the other is hydrogen; and R , R , and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) 3 wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; one of R and R is arylsulfanylalkyl and the other is hydrogen; and R , R , and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; one of R and R is arylalkylsulfanyl and the other is hydrogen; R is selected from the group consisting of arylalkenyl, arylalkoxy, cycloalkenyl, cycloalkyl, and 1 15 (heterocycle) alkoxy; and R and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) 3 wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; ; one of R and R is arylsulfanylalkyl and the other is hydrogen; R is aryl; and R and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; ; one of R and R is arylsulfanylalkyl and the other is hydrogen; R is aryl wherein the aryl is unsubstituted or has one substituent; and R and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; one of R and R is arylsulfanylalkyl and the other is hydrogen; R is aryl wherein the aryl has two substituents; and R and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; one of R and R is arylsulfanylalkyl and the other is hydrogen; R is heterocycle; and R and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected 9 5 f% from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; one of R and R is arylsulfanylalkyl and the other is hydrogen; R is heterocycle wherein the heterocycle is unsubstitued or has one substituent; and R and R are as previously defined. In another embodiment the present invention provides a compound of formula (I) wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl; R is selected from the group consisting of hydrogen, alkenyl, aryl, and heterocycle; R is -NR R ; one of R and R is arylsulfanylalkyl and the other is hydrogen; R is heterocycle wherein the heterocycle has two or three substituents; and R and R are as previously defined. In another embodiment, the present invention provides a pharmaceutical composition comprising a compound of formula (I), or a therapeutically acceptable salt thereof, in combination with a therapeutically acceptable carrier. In another embodiment, the present invention provides a method of promoting apoptosis in a mammal in recognized need thereof comprising administering to the mammal a therapeutically acceptable amount of a compound of formula (I) or a therapeutically acceptable salt thereof. Detailed Description of the Invention Compounds of the present invention comprise substituted N-benzoyl arylsulfonamides which are useful for the treatment of apoptosis-mediated diseases. As used in the present specification the following terms have the meanings indicated: The term "alkanoyl," as used herein, represents an alkyl group attached to the parent molecular moiety through a carbonyl group. The alkanoyl groups of this invention can be optionally substituted with one or two groups independently selected from the group consisting of hydroxy and -NR R , wherein R and R are as previously defined. The term "alkanoylalkyl," as used herein, represents an alkanoyl group attached to the parent molecular moiety through an alkyl group. The term "alkenyl," as used herein, represents a straight or branched chain group of one to twelve carbon atoms derived from a straight or branched chain hydrocarbon containing at least one carbon-carbon double bond. The term "alkoxy," as used herein, represents an alkyl group attached to the parent molecular moiety through an oxygen atom. The term "alkoxyalkanoyl," as used herein, represents an alkoxy group attached to the parent molecular moiety through an alkanoyl group. The term "alkoxyalkoxy," as used herein, represents an alkoxy group attached to the parent molecular moiety through another alkoxy group. The term "alkoxyalkoxyalkyl," as used herein, represents an alkoxyalkoxy group attached to the parent molecular moiety through an alkyl group. The term "alkoxyalkoxycarbonyl," as used herein, represents an alkoxyalkoxy group attached to the parent molecular moiety through a carbonyl group. The term "alkoxyalkyl," as used herein, represents an alkoxy group attached to the parent molecular moiety through an alkyl group. The term "alkoxycarbonyl," as used herein, represents an alkoxy group attached to the parent molecular moitety through a carbonyl group. The term "alkoxycarbonylalkyl," as used herein, represents an alkoxycarbonyl group attached to the parent molecular moiety through an alkyl group. The term "alkyl," as used herein, represents a group of one to twelve carbon atoms derived from a straight or branched chain saturated hydrocarbon. The term "alkylamino," as used herein, represents -N(R ) 2 , wherein R is alkyl. The term "alkylaminoalkyl," as used herein, represents an alkylamino group attached to the parent molecular moiety through an alkyl group. The term "alkylaminocarbonyl," as used herein, represents an alkylamino group attached to the parent molecular moiety through a carbonyl group. The term "alkylaminocarbonylalkyl," as used herein, represents an alkylaminocarbonyl group attached to the parent molecular moiety through an alkyl group. The term "alkylidene," as used herein, represents an alkyl group attached to the parent molecular moiety through a carbon-carbon double bond. The term "alkylsulfanyl," as used herein, represents an alkyl group attached to the parent molecular moiety through a sulfur atom. The term "alkylsulfanylalkyl," as used herein, represents an alkylsulfanyl group attached to the parent molecular moiety through an alkyl group. The term "alkylsulfonyl," as used herein, represents an alkyl group attached to the parent molecular moiety through a sulfonyl group. The term "alkylsulfonylalkyl," as used herein, represents an alkylsulfonyl group attached to the parent molecular moiety through an alkyl group. The term "alkynyl," as used herein, represents a straight or branched chain group of one to twelve carbon atoms containing at least one carbon-carbon triple bond. 9 10 . 9 10 The term "amino," as used herein, represents -NR R , wherein R and R are independently selected from the group consisting of hydrogen, alkanoyl, alkenyl, alkoxyalkyl, alkoxyalkoxyalkyl, alkoxycarbonyl, alkyl, alkylaminoalkyl, alkylaminocarbonylalkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkylcarbonyl, haloalkanoyl, haloalkyl, (heterocycle)alkyl, heterocyclecarbonyl, hydroxyalkyl, a nitrogen protecting group, -C(NH)NH 2 , and -C(O)NR R , wherein R and R are as previously defined; wherein the aryl; the aryl part of the arylalkyl; the cycloalkyl; the cycloalkyl part of the (cycloalkyl)alkyl and the cycloalkylcarbonyl; and the heterocycle part of the (heterocycle)alkyl and the heterocyclecarbonyl can be optionally substituted with one, two, three, four, or five substituents independently selected from the group consisting of alkanoyl, alkoxy, alkyl, cyano, halo, haloalkoxy, haloalkyl, hydroxy, and nitro. The term "aminoalkanoyl," as used herein, represents an amino group attached to the parent molecular moiety through an alkanoyl group. The term "aminoalkyl," as used herein, represents an amino group attached to the parent molecular moiety through an alkyl group. The term "aminocarbonyl," as used herein, represents an amino group attached to the parent molecular moiety through a carbonyl group. The term "aminocarbonylalkyl," as used herein, represents an aminocarbonyl group attached to the parent molecular moiety through an alkyl group. The term "aminosulfonyl," as used herein, represents an amino group attached to the parent molecular moiety through a sulfonyl group. The term "aryl," as used herein, represents a phenyl group or a bicyclic or tricyclic fused ring system wherein one or more of the fused rings is a phenyl group. Bicyclic fused ring systems are exemphfied by a phenyl group fused to a cycloalkyl group as defined herein, a cycloalkenyl group as defined herein, or another phenyl group. Tricyclic fused ring systems are exemphfied by a bicyclic fused ring system fused to a cycloalkyl group as defined herein, a cycloalkenyl group as defined herein, or another phenyl group. Representative examples of aryl include, but are not limited to, anthracenyl, azulenyl, fluorenyl, indanyl, indenyl, naphthyl, phenyl, and tetrahydronaphthyl. Aryl groups having an unsaturated or partially saturated ring fused to an aromatic ring can be attached through the saturated or the unsaturated part of the group. The aryl groups of this invention can be optionally substituted with one, two, three, four, or five substituents independently selected from the group consisting, of alkanoyl, alkenyl, alkoxy, alkoxyalkanoyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkynyl, amino, aminoalkyl, aminocarbonyl, aminocarbonylalkyl, aminosulfonyl, aryl, aryloxy, arylsulfanyl, carbonyloxy, cyano, halo, haloalkoxy, haloalkyl, heterocycle, (heterocycle)alkyl, heterocyclecarbonylalkenyl, heterocyclecarbonylalkyl, hydroxy, hydroxyalkyl, nitro, oxo, and -C(NH)NH 2 , wherein the aryl; the aryl part of the aryloxy and the arylsulfanyl; the heterocycle; and the heterocycle part of the (heterocycle)alkyl, the heterocyclecarbonylalkenyl, and the heterocyclecarbonylalkyl can be further optionally substituted with one, two, or three substituents independently selected from the group consisting of alkoxyalkanoyl, alkoxycarbonyl, alkyl, alkylsulfonyl, aminocarbonyl, aminosulfonyl, cyano, halo, haloalkoxy, haloalkyl, hydroxy, nitro, oxo, and -C(NH)NH 2 . In addition, the heterocycle and the heterocycle part of the (heterocycle)alkyl, the heterocyclecarbonylalkenyl, and the heterocyclecarbonylalkyl can be further optionally substituted with an additional aryl group, wherein the aryl can be optionally substituted with one, two, or three substituents independently selected from the group consisting of alkoxy, alkyl, cyano, halo, hydroxy, and nitro. The term "arylalkenyl," as used herein, represents an aryl group attached to the parent molecular moiety through an alkenyl group. The term "arylalkoxy," as used herein, represents an aryl group attached to the parent molecular moiety through an alkoxy group. The term "arylalkoxyalkanoyl," as used herein, represents an arylalkoxy group attached to the parent molecular moiety through an alkanoyl group. The term "arylalkoxycarbonyl," as used herein, represents an arylalkoxy group attached to the parent molecular moiety through a carbonyl group. The term "arylalkyl," as used herein, represents an alkyl group substituted with at least one aryl group. The alkyl part of the arylalkyl can be optionally substituted with one or two amino groups. The term "arylalkylsulfanyl," as used herein, represents an arylalkyl group attached to the parent molecular moiety through a sulfur atom. The term "arylalkylsulfanylalkyl," as used herein, represents an arylalkylsulfanyl group attached to the parent molecular moiety through an alkyl group. The term "arylalkylsulfonyl," as used herein, represents an arylalkyl group attached to the parent molecular moiety through a sulfonyl group. The term "arylcarbonyl," as used herein, represents an aryl group attached to the parent molecular moiety through a carbonyl group. The term "aryloxy," as used herein, represents an aryl group attached to the parent molecular moiety through an oxygen atom. The term "aryloxyalkoxy," as used herein, represents an aryloxy group attached to the parent molecular moiety through an alkoxy group. The term "aryloxyalkyl," as used herein, represents an aryloxy group attached to the parent molecular moiety through an alkyl group. The term "arylsulfanyl," as used herein, represents an aryl group attached to the parent molecular moiety through a sulfur atom. The term "arylsulfanylalkoxy," as used herein, represents an arylsulfanyl group attached to the parent molecular moiety through an alkoxy group. The term "arylsulfanylalkyl," as used herein, represents an arylsulfanyl group attached to the parent molecular moiety through an alkyl group. The alkyl part of the arylsulfanylalkyl can be optionally substituted with one or two substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, amino, aminocarbonyl, arylalkoxy, azido, carboxy, cycloalkyl, halo, heterocycle, (heterocycle)alkoxy, (heterocycle)carbonyl, and hydroxy. The term "arylsulfinyl," as used herein, represents an aryl group attached to the parent molecular moiety through a sulfinyl group. The term "arylsulfinylalkyl," as used herein, represents an arylsulfinyl group attached to the parent molecular moiety through an alkyl group. The alkyl part of the arylsulfinylalkyl can be optionally substituted with one or two amino groups. The term "arylsulfonyl," as used herein, represents an aryl group attached to the parent molecular moiety through a sulfonyl group. The term "arylsulfonylalkyl," as used herein, represents an arylsulfonyl group attached to the parent molecular moiety through an alkyl group. The alkyl part of the arylsulfonylalkyl can be optionally substituted with one or two amino groups. The term "azido," as used herein, represents -N 3 . The term "carbonyl," as used herein, represents -C(O)-. The term "carbonyloxy," as used herein, represents an alkanoyl group attached to the parent molecular moiety through an oxygen atom. The term "carboxy," as used herein, represents -CO 2 H. The term " carboxyalkyl," as used herein, represents a carboxy group attached to the parent molecular moiety through an alkyl group. The term "cyano," as used herein, represents -CN. The term "cyanoalkyl," as used herein, represents a cyano group attached to the parent molecular moiety through an alkyl group. The term "cycloalkenyl," as used herein, represents anon-aromatic ring system having three to ten carbon atoms and one to three rings, wherein each five-membered ring has one double bond, each six-membered ring has one or two double bonds, each seven- and eight-membered ring has one to three double bonds, and each nine-to ten-membered ring has one to four double bonds. Examples of cycloalkenyl groups include cyclohexenyl, octahydronaphthalenyl, norbornylenyl, and the Hke. The cycloalkenyl groups of this invention can be optionally substituted with one, two, three, four, or five substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, alkyl, aminoalkyl, arylalkoxy, aryloxy, arylsulfanyl, halo, haloalkoxy, haloalkyl, and hydroxy, wherein the aryl part of the arylalkoxy, the aryloxy, and the arylsulfanyl can be further optionally substituted with one, two, or three substituents independently selected from the group consisting of alkoxy, alkyl, halo, haloalkoxy, haloalkyl, and hydroxy. The term "cycloalkenylalkyl," as used herein, represents a cycloalkenyl group attached to the parent molecular moiety through an alkyl group. The term "cycloalkyl," as used herein, represents a saturated ring system having three to twelve carbon atoms and one to three rings. Examples of cycloalkyl groups include cyclopropyl, cyclopentyl, bicyclo(3.1. l)heptyl, adamantyl, and the Hke. The cycloalkyl groups of this invention can be optionally substituted with one, two, three, four, or five substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, alkyl, aminoalkyl, arylalkoxy, aryloxy, arylsulfanyl, halo, haloalkoxy, haloalkyl, and hydroxy, wherein the aryl part of the arylalkoxy, the aryloxy, and the arylsulfanyl can be further optionally substituted with one, two, or three substituents independently selected from the group consisting of alkoxy, alkyl, halo, haloalkoxy, haloalkyl, and hydroxy. The term "cycloalkylalkoxy," as used herein, represents a cycloalkyl group attached to the parent molecular moiety through an alkoxy group. The term "(cycloalkyl)alkyl," as used herein, represents a cycloalkyl group attached to the parent molecular moiety through an alkyl group. The term "cycloalkylcarbonyl," as used herein, represents a cycloalkyl group attached to the parent molecular moiety through a carbonyl group. The term "cycloalkyloxy," as used herein, represents a cycloalkyl group attached to the parent molecular moiety through an oxygen atom. The term "formyl," as used herein, represents -CHO. The term "formylalkyl," as used herein, represents a formyl group attached to the parent molecular moiety through an alkyl group. The term "halo," as used herein, represents F, Cl, Br, or I. The term "haloalkanoyl," as used herein, represents a haloalkyl group attached to the parent molecular moiety through a carbonyl group. The term "haloalkoxy," as used herein, represents a haloalkyl group attached to the parent molecular moiety through an oxygen atom. The term "haloalkyl," as used herein, represents an alkyl group substituted by one, two, three, or four halogen atoms. The term "heteroalkenylene," as used herein, represents a divalent group of three to eight atoms derived from a straight or branched chain containing at least one carbon-carbon double bond that contains one or two heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the remaining atoms are carbon. The heteroalkenylene groups of the present invention can be attached to the parent molecular moiety through the carbon atoms or the heteroatoms in the chain. The term "heteroalkylene," as used herein, represents a divalent group of two to eight atoms derived from a saturated straight or branched chain containing one or two heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the remaining atoms are carbon. The heteroalkylene groups of the present invention can be attached to the parent molecular moiety through the carbon atoms or the heteroatoms in the chain. The term "heterocycle," as used herein, represents a monocyclic, bicyclic, or tricyclic ring system wherein one or more rings is a four-, five-, six-, or seven-membered ring containing one, two, or three heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur. MonocycHc ring systems are exemplified by any 3- or 4- membered ring containing a heteroatom independently selected from the group consisting of oxygen, nitrogen and sulfur; or a 5-, 6- or 7-membered ring containing one, two or three heteroatoms wherein the heteroatoms are independently selected from the group consisting of nitrogen, oxygen and sulfur. The 3- and 4-membered rings have no double bonds, the 5- membered ring has from 0-2 double bonds and the 6- and 7-membered rings have from 0-3 double bonds. Representative examples of monocyclic ring systems include, but are not limited to, azetidine, azepine, aziridine, diazepine, 1,3-dioxolane, dioxane, dithiane, furan, imidazole, imidazoline, imidazohdine, isothiazole, isothiazoline, isothiazohdine, isoxazole, isoxazoHne, isoxazohdine, morphohne, oxadiazole, oxadiazoHne, oxadiazoHdine, oxazole, oxazohne, oxazolidine, piperazine, piperidine, pyran, pyrazine, pyrazole, pyrazoline, pyrazolidine, pyridine, pyrimidine, pyridazine, pyrrole, pyrroline, pyrrolidine, tetrahydrofuran, tetrahydrothiophene, tetrazine, tetrazole, thiadiazole, thiadiazoline, thiadiazolidine, thiazole, thiazohne, thiazolidine, thiophene, thiomorphoHne, thiomorpholine sulfone, thiopyran, triazine, triazole, trithiane, and the Hke. BicycHc ring systems are exemplified by any of the above monocyclic ring systems fused to an aryl group as defined herein, a cycloalkyl group as defined herein, a cycloalkenyl group, as defined herein, or another monocyclic heterocycle ring system. Representative examples of bicyclic ring systems include but are not Hmited to, benzimidazole, benzothiazole, benzothiophene, benzoxazole, benzo furan, benzopyran, benzothiopyran, benzodioxine, 1,3-benzodioxole, cinnoHne, indazole, indole, indohne, indoHzine, naphthyridine, isobenzofuran, isobenzothiophene, isoindole, isoindoHne, isoquinoline, phthalazine, pyranopyridine, quinoline, quinolizine, quinoxaline, quinazoHne, tetrahydroisoquinohne, tetrahydroquinoHne, thiopyranopyridine, and the Hke. Tricyclic rings systems are exemplified by any of the above bicyclic ring systems fused to an aryl group as defined herein, a cycloalkyl group as defined herein, a cycloalkenyl group as defined herein, or another monocychc heterocycle ring syste Representative examples of tricyclic ring systems include, but are not limited to, acridine, carbazole, carboHne, dibenzofuran, dibenzothiophene, naphthofuran, naphthothiophene, oxanthrene, phenazine, phenoxathiin, phenoxazine, phenothiazine, thianthrene, thioxanthene, xanthene, and the like. Heterocycle groups can be attached to the parent molecular moiety through a carbon atom or a nitrogen atom in the group. The heterocycle groups of the present invention can be optionally substituted with one, two, three, four, or five substituents independently selected from the group consisting of alkanoyl, alkanoylalkyl, alkenyl, alkoxy, alkoxyalkoxycarbonyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylsulfanylalkyl, alkynyl, amino, aminoalkanoyl, aminoalkyl, aminocarbonyl, aminocarbonylalkyl, aminosulfonyl, aryl, arylalkoxyalkanoyl, arylalkoxycarbonyl, arylalkyl, arylalkylsulfonyl, arylcarbonyl, aryloxy, arylsulfanyl, arylsulfanylalkyl, arylsulfonyl, carbonyloxy, carboxy, cyano, cyanoalkyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkylcarbonyl, formyl, formylalkyl, halo, haloalkoxy, haloalkyl, heterocycle, (heterocycle)alkyl, (heterocycle)alkylidene, heterocyclecarbonyl, heterocyclecarbonylalkyl, hydroxy, hydroxyalkyl, nitro, oxo, spirocycle, spiroheterocycle, and -C(NH)NH 2 ; wherein the aryl; the aryl part of the arylalkylsulfonyl, the arylcarbonyl, the aryloxy, the arylalkoxyalkanoyl, the arylalkoxycarbonyl, the arylalkyl, the arylsulfanyl, the arylsulfanylalkyl, and the arylsulfonyl; the heterocycle; and the heterocycle part of the (heterocycle)alkyl, the (heterocycle)alkylidene, the heterocyclecarbonyl, and the heterocyclecarbonylalkyl can be further optionally substituted with one, two, three, four, or five substituents independently selected from the group consisting of alkanoyl, alkoxy, alkoxyalkoxycarbonyl, alkoxycarbonyl, alkyl, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, and nitro. The term "(heterocycle)alkoxy," as used herein, represents a heterocycle group attached to the parent molecular moiety through an alkoxy group. The term "(heterocycle)alkyl," as used herein, represents a heterocycle group attached to the parent molecular moiety through an alkyl group. The term "(heterocycle)alkylidene," as used herein, represents a heterocycle group attached to the parent molecular moiety through an alkylidene group. The term "heterocyclecarbonyl," as used herein, represents a heterocycle group attached to the parent molecular moiety through a carbonyl group. The term "heterocyclecarbonylalkenyl," as used herein, represents a heterocyclecarbonyl group attached to the parent molecular moiety through an alkenyl group. The term "heterocyclecarbonylalkyl," as used herein, represents a heterocyclecarbonyl group attached to the parent molecular moiety through an alkyl group. The term "(heterocycle)oxy," as used herein, represents a heterocycle group attached to the parent molecular moiety through an oxygen atom. The term "(heterocycle)sulfanyl," as used herein, represents a heterocycle group attached to the parent molecular moiety through a sulfur atom. The term "(heterocycle)sulfanylalkyl," as used herein, represents a heterocyclesulfanyl group attached to the parent molecular moiety through an alkyl group. The term "hydroxy," as used herein, represents -OH. The term "hydroxyalkyl," as used herein, represents a hydroxy group attached to the parent molecular moiety through an alkyl group. The term "nitro," as used herein, represents -NO 2 . The term "nitrogen protecting group," as used herein, represents groups intended to protect an amino group against undesirable reactions during synthetic procedures. Common N-protecting groups comprise acyl groups such as acetyl, benzoyl, 2-bromoacetyl, 4- bromobenzoyl, tert-butylacetyl, carboxaldehyde, 2-chloroacetyl, 4-chlorobenzoyl, a- chlorobutyryl, 4-nitrobenzoyl, o-nitrophenoxyacetyl, phthalyl, pivaloyl, propionyl, trichloroacetyl, and trifluoroacetyl; sulfonyl groups such as benzenesulfonyl, and p- toluenesulfonyl; carbamate forming groups such as benzyloxycarbonyl, benzyloxycarbonyl (Cbz), tert-butyloxycarbonyl (Boc), p-chlorobenzyloxycarbonyl, p- methoxybenzyloxycarbonyl, and the Hke. The term "oxo," as used herein, represents (=O). The term "spirocycle," as used herein, represents an alkyl diradical of two to eight atoms, each end of which is attached to the same carbon atom of the parent molecular moiety. The term "spiroheterocycle," as used herein, represents a heteroalkylene diradical, each end of which is attached to the same carbon atom of the parent molecular moiety. Examples of spiroheterocycles include dioxolanyl, tetrahydrofuranyl, pyrroHdinyl, and the like. The term "sulfϊnyl," as used herein, represents -S(O)-. The term "sulfonyl, " as used herein, represents -SO 2 -. The term "therapeutically acceptable salt," as use herein, represents those salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response and the like and are commensurate with a reasonable benefit/risk ratio. The salts can be prepared in situ during the final isolation and purification of the compounds of the present invention or separately by reacting a free base group with a suitable organic acid. Representative acid addition salts include acetate, adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, camphorate, camphorsulfonate, citrate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptonate, glycerophosphate, hemisulfate, heptonate, hexanoate, hydrobromide, hydrochloride, hydroiodide, 2-hydroxy-ethanesulfonate, lactobionate, lactate, laurate, lauryl sulfate, malate, maleate, malonate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oleate, oxalate, palmitate, pamoate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, stearate, succinate, sulfate, tartrate, thiocyanate, toluenesulfonate, trifluoroacetate, undecanoate, valerate salts, and the Hke. Representative alkali or alkaline earth metal salts include calcium, Hthium, magnesium, potassium, sodium, and the Hke, as well as non-toxic ammonium, quaternary ammonium, and amine cations, including, but not limited to, ammonium, dimethylamine, ethylamine, methylamine, tetraethylammonium, tetramethylammonium, triethylamine, trimethylamine, and the Hke. Basic addition salts can be prepared during the final isolation and purification of the compounds by reacting a carboxy group with a suitable base such as the hydroxide, carbonate, or bicarbonate of a metal cation or with ammonia or an organic primary, secondary, or tertiary amine. The cations of therapeutically acceptable salts include Hthium, sodium, potassium, calcium, magnesium, and aluminum, as well as nontoxic quaternary amine cations such as ammonium, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylamine, diethylamine, ethylamine, tributylamine, pyridine, N,N-dimethylaniline, N-methylpiperidine, N-methylmorphoHne, dicyclohexylamine, procaine, dibenzylamine, N,N-dibenzylphenethylamine, 1-ephenamine, and N,N'-dibenzylethylenediamine. Other representative organic amines useful for the formation of base addition salts include ethylenediamine, ethanolamine, diethanolamine, piperidine, and piperazine. The present compounds can also exist as therapeutically acceptable prodrugs. The term "therapeutically acceptable prodrug," refers to those prodrugs or zwitterions which are suitable for use in contact with the tissues of patients without undue toxicity, irritation, and allergic response, are commensurate with a reasonable benefit/risk ratio, and are effective for their intended use. The term "prodrug," refers to compounds which are rapidly transformed in vivo to parent compounds of formula (I) for example, by hydrolysis in blood. Asymmetric centers exist in the compounds of the present invention. These centers are designated by the symbols "R" or "S," depending on the configuration of substituents around the chiral carbon atom. It should be understood that the invention encompasses all stereochemical isomeric forms, or mixtures thereof, which possess the bihty to induce apoptosis. Individual stereoisomers of compounds can be prepared synthetically from commercially available starting materials which contain chiral centers or by preparation of mixtures of enantiomeric products followed by separation such as conversion to a mixture of diastereomers followed by separation or recrystaUization, chromatographic techniques, or direct separation of enantiomers on chiral chromatographic columns. Starting compounds of particular stereochemistry are either commercially available or can be made and resolved by techniques known in the art. According to methods of treatment, the compounds of the present invention can be useful for the prevention of metastases from the tumors described above either when used alone or in combination with radiotherapy and/or other chemotherapeutic treatments conventionally administered to patients for treating cancer. When using the compounds of the present invention for chemotherapy, the specific therapeutically effective dose level for any particular patient will depend upon factors such as the disorder being treated and the severity of the disorder; the activity of the particular compound used; the specific composition employed; the age, body weight, general health, sex, and diet of the patient; the time of administration; the route of administration; the rate of excretion of the compound employed; the duration of treatment; and drugs used in combination with or coincidently with the compound used. For example, when used in the treatment of soHd tumors, compounds of the present invention can be administered with chemotherapeutic agents such as alpha inteferon, COMP (cyclophosphamide, vincristine, methotrexate, and prednisone), etoposide, mBACOD (methortrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone), PRO-MACE/MOPP (prednisone, methotrexate (w/leucovin rescue), doxorubicin, cyclophosphamide, taxol, etoposide/mechlorethamine, vincristine, prednisone, and procarbazine), vincristine, vinblastine, angioinhibins, TNP-470, pentosan polysulfate, platelet factor 4, angiostatin, LM-609, SU-101, CM- 101, Techgalan, thalidomide, SP-PG, and the like. For example, a tumor may be treated conventionally with surgery, radiation or chemotherapy and a compound of the present invention subsequently administered to extend the dormancy of micrometastases and to stabilize and inhibit the growth of any residual primary tumor. The compounds of the present invention can be administered orally, parenterally, osmotically (nasal sprays), rectaUy, vaginally, or topically in unit dosage formulations containing carriers, adjuvants, diluents, vehicles, or combinations thereof. The term "parenteral" includes infusion as well as subcutaneous, intravenous, intramuscular, and intrasternal injection. ParenteraHy administered aqueous or oleaginous suspensions of the compounds of the present invention can be formulated with dispersing, wetting, or suspending agents. The injectable preparation can also be an injectable solution or suspension in a diluent or solvent. Among the acceptable diluents or solvents employed are water, saline, Ringer's solution, buffers, dilute acids or bases, dilute amino acid solutions, monoglycerides, diglycerides, fatty acids such as oleic acid, and fixed oils such as monoglycerides or diglycerides. The chemotherapeutic effect of parenterally administered compounds can be prolonged by slowing their absorption. One way to slow the absorption of a particular compound is administering injectable depot forms comprising suspensions of crystaUine, amorphous, or otherwise water-insoluble forms of the compound. The rate of absorption of the compound is dependent on its rate of dissolution which is, in turn, dependent on its physical state. Another way to slow absorption of a particular compound is administering injectable depot forms comprising the compound as an oleaginous solution or suspension. Yet another way to slow absorption of a particular compound is administering injectable depot forms comprising microcapsule matrices of the compound trapped within liposomes, microemulsions, or biodegradable polymers such as polylactide-polyglycoHde, polyorthoesters or poly anhydrides. Depending on the ratio of drug to polymer and the composition of the polymer, the rate of drug release can be controUed. Transdermal patches also provide controUed delivery of the compounds. The rate of absorption can be slowed by using rate controUing membranes or by trapping the compound within a polymer matrix or gel. Conversely, absorption enhancers can be used to increase absorption. SoHd dosage forms for oral administration include capsules, tablets, pUls, powders, and granules. In these sohd dosage forms, the active compound can optionally comprise diluents such as sucrose, lactose, starch, talc, sUicic acid, aluminum hydroxide, calcium silicates, polyamide powder, tableting lubricants, and tableting aids such as magnesium stearate or microcrystaUine cellulose. Capsules, tablets and pUls can also comprise buffering agents; and tablets and pUls can be prepared with enteric coatings or other release-controUing coatings. Powders and sprays can also contain excipients such as talc, sUicic acid, aluminum hydroxide, calcium silicate, polyamide powder, or mixtures thereof. Sprays can additionally contain customary propeUants such as chloro fluorohydrocarbons or substitutes thereof. Liquid dosage forms for oral administration include emulsions, microemulsions, solutions, suspensions, syrups, and elixirs comprising inert diluents such as water. These compositions can also comprise adjuvants such as wetting, emulsifying, suspending, sweetening, flavoring, and perfuming agents. Topical dosage forms include ointments, pastes, creams, lotions, gels, powders, solutions, sprays, inhalants, and transdermal patches. The compound is mixed under sterUe conditions with a carrier and any needed preservatives or buffers. These dosage forms can also include excipients such as animal and vegetable fats, oUs, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, sUicic acid, talc and zinc oxide, or mixtures thereof. Suppositories for rectal or vaginal administration can be prepared by mixing the compounds of the present invention with a suitable nonirritating excipient such as cocoa butter or polyethylene glycol, each of which is solid at ordinary temperature but fluid in the rectum or vagina. Ophthalmic formulations comprising eye drops, eye ointments, powders, and solutions are also contemplated as being within the scope of the present invention. The total daily dose of the compounds of the present invention administered to a host in single or divided doses can be in amounts from about 0.1 to about 200 mg/kg body weight or preferably from about 0.25 to about 100 mg/kg body weight. Single dose compositions can contain these amounts or submultiples thereof to make up the daily dose. Determination of Biological Activity Assays for the inhibition of BCL-Xl were performed in 96-weU microtiter plates. Compounds of the present invention were dUuted in DMSO to concentrations between 100 μM and 1 pM and introduced into each cell of the plate. A mixture totaling 125 μL per weU of assay buffer (20 mM phosphate buffer (pH 7.4), 1 mM EDTA, 0.05% PEG-8000), 50 nM of BCL-Xl protein (prepared according to the procedure described in Science 1997, 275, 983-986), 5 nM fluorescein-labeled BAD peptide (purchased from Synpep, CA), and the DMSO solution of the compound of the present invention was shaken for 2 minutes and placed in a LJL Analyst (LJL Bio Systems, CA). A negative control (DMSO, 5 nM BAD peptide, assay buffer) and a positive control (DMSO, 5 nM BAD peptide, 50 nM BCL-Xl, assay buffer) were used to determine the range of the assay. Polarization was measured at room temperature using a continuous Fluorescein lamp (excitation 485 mM, emission 530 mM). Percentage of inhibition was determined by (l-((mP value of well-negative control)/range)) x 100%. IC 50 values were calculated using Microsoft Excel. Compounds of the present invention have IC 50 values between 0.011 and 10 μM and are therefore useful for inhibiting BCL-Xl and treating apoptosis- mediated diseases. Preferred compounds of the present invention have IC 50 values between 0.011 and 0.5 μM, and most preferred compounds have IC50 values between 0.011 and 0.10 μM. Assays for the inhibition of BCL-2 were performed in 96-well microtiter plates. Compounds of the instant invention were dUuted in DMSO to concentrations between 100 μM and 1 pM and introduced into each weU of the plate. A mixture totahng 125 μL per well of assay buffer (20 mM phosphate buffer (pH 7.4), 1 mM EDTA, 0.05% PF-68), 30 nM of BCL-2 protein (prepared according to the procedure described in PNAS 2001, 98, 3012 - 3017), 5 nM fluorescein-labeled BAX peptide (prepared in-house), and the DMSO solution of the compound of the instant invention was shaken for 2 minutes and placed in a LJL Analyst (LJL Bio Systems, CA). A negative control (DMSO, 5 nM BAX peptide, assay buffer) and a positive control (DMSO, 5 nM BAX peptide, 30 nM BCL-2, assay buffer) were used to determine the range of the assay. Polarization was measured at room temperature using a continuous Fluorescein lamp (excitation 485 mM, emission 530 mM). Percentage of inhibition was determined by (l-((mP value of well-negative control)/range)) x 100%. IC 50 values were calculated using Microsoft Excel. Compounds of the present invention have IC 50 values between 0.017 and 10 μM and are therefore useful for inhibiting BCL-2 and treating apoptosis-mediated diseases. Preferred compounds of the present invention have IC 50 values between 0.017 and 0.5 μM, and most preferred compounds have IC50 values between 0.017 and 0.20 μM. Based upon the structural and functional similarity of the BCL antiapoptotic proteins, it is reasonable to expect that in addition to inducing apoptosis by the inhibition of BCL-Xl and BCL-2, the current invention may induce apoptosis through their action on other antiapoptotic proteins in the Bel famUy of proteins, such as BCL-w, BCL-b, MCL-1 and/or Al/Bfl-1. Synthetic Methods Abbreviations which have been used in the descriptions of the scheme and the examples that follow are: OAc for acetate; CyMAP-1 for 2-dicyclohexylphosphino-2'-(N,N- dimethylamino)biphenyl; dba for dibenzylideneacetone; dppf for diphenylphosphino ferrocene; DMF for N,N-dimethylformamide; DME for 1,2- dimethoxyethane; THF for tetrahydrofuran; MTBE for methyl tert-butyl ether; NMP for N- methylpyrroldinone; TFP for ttis-2-furylphosphine; EDCI for l-ethyl-3-(3- (dimethylamino)propyl)-carbodnrnide hydrochloride; DMAP for 4-dimethylaminopyridine; DCC for 1,3-dicyclohexylcarbodiimide; CDl for l,r-carbonyldiimidazole; DMSO for dimethylsulfoxide; TFA for trifluoroacetic acid; NaHMDS for sodium hexamethyldisilazide; LAH for Hthium aluminum hydride; p-TsOH for p-toluenesulfonic acid; DIBAL-H for dnsobutylaluminum hydride; Fmoc for 9-fluorenylmethyl carbamate; Asp(OtBu)-OH for aspartic acid (4-tert-butyl ester); Lys(BOC)-OH for N ε -tert-butyoxycarbonyl lysine; HOBT for 1-hydroxybenzotriazole; BOC for tert-butoxycarbonyl; DEAD for diethyl azodicarboxylate; TBAF for tetrabutylammonium fluoride; BINAP for 2,2'- bis(diphenylphosphino)-l,l'-binaphthyl; Boc-Ser-OMe for N-tert-butoxycarbonyl serine methyl ester; DMA for N,N-dimethylacetamide; and HMPA for hexamethylphosphoramide. The compounds and processes of the present invention wUl be better understood in connection with the foUowing synthetic schemes which illustrate the methods by which the 1 2 3 4 compounds of the invention may be prepared. The groups R , R , R , and R are as defined above unless otherwise noted below. It wUl be readUy apparent to one of ordinary skill in the art that the compounds defined above can be synthesized by substitution of the appropriate reactants and agents in the syntheses shown below. It wUl also be apparent that protection and deprotection steps, as well as the order of the steps themselves, can be carried out in varying order to successfully complete the syntheses of compounds of the present invention. This invention is intended to encompass compounds of formula (I) when prepared by synthetic processes or by metabohc processes. Preparation of the compounds of the invention by metabohc processes include those occurring in the human or animal body (in vivo) or processes occurring in vitro. Scheme 1 OR 12 R 1 1 0 2 C-Ar-X + R -£ 0R 12 *" R 11 0 2 C-Ar-R 4 (1) (2) (3) As shown in Scheme 1, compounds of formula (1) (Ar is aryl or heterocycle; X is halo; R is alkyl) can be reacted with compounds of formula (2) (R is an unsaturated group 12 such as aryl or alkenyl; R is hydrogen or alkyl) in the presence of catalytic paUadium and base to provide compounds of formula (3). Examples of paUadium catalysts include Pd(PPh 3 ) 4 , Pd(OAc) 2 /CyMAP-l, and Pd 2 (dba) 3 /AsPh 3 , and Pd(dppf)Cl 2 -CH 2 Cl 2 . Representative bases include Na 2 CO 3 , CsF, and CS 2 CO 3 . Examples of solvents used in these reactions include toluene, dioxane, DMF, ethanol, DME, and mixtures thereof. The reaction temperature is about 75 °C to about 120 °C and depends on the method chosen. Reaction times are typically about 1 to about 24 hours. Compounds of formula (3) (R is alkyl) can be hydrolyzed in the presence of aqueous base to form compounds of formula (3) (R 11 is hydrogen). Examples of bases include LiOH, NaOH, and KOH. Representative solvents include water, THF, dioxane, and mixtures thereof. The reaction temperature is about 25 °C to about 60 °C and depends on the method chosen. Reaction times are typically about 1 to about 18 hours. Scheme 2 R 1 1 0 2 C-Ar-B(OR 12 ) 2 + R 4 -X R 11 0 2 C-Ar-R 4 (4) (5) (3) An alternative synthesis of compounds of formula (3) is shown in Scheme 2. Compounds of formula (4) (Ar is optionaUy substituted aryl or optionally substituted heterocycle; R 11 is hydrogen or alkyl; R 12 is hydrogen or alkyl) can be reacted with compounds of formula (5) (R is previously defined; X is halo or triflate) using the conditions described in Scheme 1 to provide compounds of formula (3). Scheme 3 (6) (7) (8) As shown in Scheme 3, compounds of formula (6) (X is F or Cl) can be converted to compounds of formula (7) by treatment with ammonium hydroxide. Examples of solvents used in this reaction include diethyl ether, THF, and MTBE. The reaction temperature is about -5 °C to about 25 °C and reaction times are typically about 15 minutes to about 1 hour. In a preferred embodiment, compounds of formula (6) in diethyl ether at 0 °C are treated with concentrated ammonium hydroxide and stirred for 30 minutes to provide compounds of formula (7). The method chos of formula (8) is dependent formed by treating compounds of formula (7) with the appropriately substituted amine. Examples of solvents used in this reactions include DMF, dioxane, and NMP. Reaction temperatures are about 35 °C to about 130 °C and reaction times are typically about 8 to about 24 hours. Compounds of formula (8) wherein R is alkoxy, alkylsulfanyl, aryloxy, arylsulfanyl, cycloalkylalkoxy, cycloalkyloxy, (heterocycle)oxy, or perfluoroalkoxy can be formed by treating compounds of formula (7) with the appropriately substituted alcohol in the presence of base. Representative bases include NaH/15-crown-5, and aH, KH/18- crown-6. Examples of solvents used in this reaction include DMF, THF, NMP, and dioxane. The reaction temperature is about 20 °C to about 120 °C and the reaction times are typicaUy about 30 minutes to about 24 hours. Scheme 4 (8) (10) (12) As shown in Scheme 4, compounds of formula (8) can be reacted with 1,3-dibromo- 5,5-dimethylhydantoin (9) in the presence of trifluoracetic acid to provide compounds of formula (10). Examples of solvents used in this reaction include dichloromethane, 1,2- dichloroethane, and chloroform. The reaction temperature is about 20 °C to about 35 °C, and the reaction time is typically about 6 to about 24 hours. In a preferred embodiment, compounds of formula (8) in dichloromethane at room temperature are treated with 1 ,3- dibromo-5,5-dimethylhydantoin (9) and stirred for 18 hours to provide compounds of formula (10). Compounds of formula (10) can be converted to compounds of formula (12) by 13 couphng with compounds of formula (11) (M is SnBu 3 or B(OR ) 2 ) in the presence of a palladium catalyst. Representative paUadium catalysts include Pd(PPh 3 )- f , Pd(dppf)Cl 2 -CH 2 Cl 2 , and Pd 2 (dba) 3 /TFP. Examples of solvents include acetonitrUe, dioxane, and DMF. The reaction temperature is about 35 °C to about 110 °C and depends on the method chosen. Reaction times are typically about 8 to about 48 hours. Scheme 5 (3) (12) - (13) As shown in Scheme 5, compounds of formula (3) (R is hydrogen) can be reacted with compounds of formula (13) in the presence of an activating agent to provide compounds of formula (14). Representative activating agents include EDCJJDMAP, DCC/DMAP, and CDI/DMAP. Examples of solvents used in these reactions include dichloromethane, chloroform, and DMF. The reaction temperature is about 20 °C to about 40 °C and depends on the method chosen. Reaction times are typically about 8 to about 24 hours. Scheme 6 Scheme 6 shows the synthesis of compounds of formula (18) (a is 0-5 and each R is a heterocycle substituent). Compounds of formula (14) (R is alkyl) can be reacted with compounds of formula (15) in the presence of acetyl chloride to provide compounds of formula (16). Examples of solvents used in these reactions include 1,2-dichloroethane, chloroform, and carbon tetrachloride. The reaction is conducted at about 80 to about 90 °C for about 1 to about 6 hours. Conversion of compounds of formula (16) to compounds of formula (17) can be accomplished by treatment with a reducing agent. Representative reducing agents include BF 3 -Et 2 θ/NaBH-t and B 2 H 6 . Examples of solvents used in these reactions include diethyl ether, THF, toluene, and dichloromethane. The reaction is conducted at about 0 °C to about 100 °C and reaction times are typically about 1 to about 12 hours. Compounds of formula (17) can be converted to compounds of formula (18) foUowing the methods described in Scheme 5. The present invention will now be described in connection with certain preferred embodiments which are not intended to Hmit its scope. On the contrary, the present invention covers aU alternatives, modifications, and equivalents as can be included within the scope of the claims. Thus, the following examples, which include preferred embodiments, wUl illustrate the preferred practice of the present invention, it being understood that the examples are for the purposes of Ulustration of certain preferred embodiments and are presented to provide what is believed to be the most useful and readily understood description of its procedures and conceptual aspects. Compounds of the invention were named by ACD/ChemSketch version 4.5 (developed by Advanced Chemistry Development, Inc., Toronto, ON, Canada) or were given names which appeared to be consistent with ACD nomenclature. Example 1 4-((2.2-dimethylcvclopentyl)amino -N-((4'-fluoro(l , 1 '-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide Example 1A methyl 4'-fluoro(l.1 '-biphenyl)-4-carboxylate A mixture of methyl 4-bromobenzoate (21.5 g, 100 mmol), 4-fluorophenylboronic acid (14.7 g, 105 mmol), Pd(dppf)Cl 2 -CH 2 Cl 2 (1.48 g, 2.0 mmol), and 2M Na 2 CO 3 (100 mL) in toluene (200 mL) and was heated to reflux, stirred for 10 hours, dUuted with ethyl acetate (200 mL), washed with water (100 mL) and brine (50 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was recrystaUized from ethyl acetate/hexanes to provide the desired product. The mother Hquor was concentrated and purified by flash column chromatography on silica gel with 10% ethyl acetate/hexanes to provide additional product. MS (DCI) m/e 231 (M+H) + . Example IB 4'-fluoro( 1 , 1 '-biphenyD-4-carboxylic acid A room temperature solution of Example 1A (10.0 g, 43.4 mmol) and saturated LiOH (50 mL) in THF (100 mL) was stirred for 16 hours, slowly adjusted to pH 2-4 with 6M HCl, diluted with ethyl acetate (200 mL), washed with water (100 mL) and brine (50 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product of sufficient purity for subsequent use. MS (ESI(-)) m/e 215 (M-H) " . Example IC 4-chloro-3-nitrobenzenesulfonamide A 0 °C solution of 4-chloro-3-nitrobenzenesulfonyl chloride (12.8 g, 50.0 mmol) in diethyl ether (1 L) was slowly treated with 0 °C concentrated NH 4 OH (50 mL) and stirred for 30 minutes. The organic layer was dried (MgSO 4 ), filtered, and concentrated to provide the desired product of sufficient purity for subsequent use. Example ID 4-chloro-N-((4'-fluoro(l, -biphenyl)-4-yl)carbonyl)-3-nitrobenzenesulfonamide A room temperature solution of Example IB (4.54 g, 21.0 mmol), Example IC (4.74 g, 20.0 mmol), EDCI (4.80 g, 25.0 mmol), and DMAP (1.23 mg, 10.0 mmol) in dichloromethane (60 mL) was stirred for 16 hours, diluted with ethyl acetate (200 mL), washed sequentially with 1M HCl (50 mL), water (50 mL) and brine (20 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sifica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 433 (M-H) " . Example IE 4-((2,2-dimethylcyclopentyl)amino)-N-((4'-fluoro(l , 1 '-biphenyl)-4-yf)carbonyι)-3- nitrobenzenesulfonamide A solution of Example ID (50 mg, 0.12 mmol) and 2,2-dimethylcyclopentylamine (65 mg, 0.58 mmol) in DMF (2.0 mL) was heated to 120 °C in a sealed vial with shaking for 16 hours. The mixture was concentrated, dissolved in 1: 1/DMSO: methanol (1.0 mL) and purified by reverse phase preparative HPLC using 0.1 % TFA in H 2 O/CH 3 CN to provide the desired product. MS (APCI(+)) m/e 529 (M+NE ) " * " ; H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.69 (d, IH), 8.49 (d, IH), 7.99 (dd, IH), 7.97 (d, 2H), 7.80 (2d, 4H), 7.39 (d, IH), 7.33 (t, 2H), 3.88 (ddd, IH), 2.28-2.25 (m, IH), 1.75-1.55 (m, 5H), 1.07 (s, 3H), 1.02 (s, 3H). Example 2 4-(cyclohexylamino)-N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting cyclohexylamine for 2,2- dimethylcyclopentylamine in Example IE. MS (ESI(-)) m/e 496 (M-H) " ; H NMR (300 MHz, CDCI 3 ) δ 8.94 (d, IH), 8.55 (m, 2H), 8.16 (dd, IH), 7.83 (d, 2H), 7.62 (d, 2H), 7.55 (m, 5H), 7.16 (m, 2H), 6.98 (d, IH), 3.60 (br s, IH), 2.05 (m, 2H), 1.90-1.25 (m, 8H). Example 3 N-((4'-bromo(l.r-biphenyl)-4-yl)carbonyl)-4-(cvclohexylamino)-3-nitrobenzenesulfonamide Example 3A 4-(cyclohexylamino)-3-nitrobenzenesulfonamide A room temperature solution of Example IC (2.36 g, 10.0 mmol) and cyclohexylamine (2.0 mL) in dioxane (5 mL) was stirred for 16 hours, dUuted with ethyl acetate (100 mL), washed sequentiaUy with 3M HCl (20 mL), water (20 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product of sufficient purity for subsequent use. Example 3B 4-(4 A5,5-tetramethyl-l .3.2-dioxaborolan-2-yι)benzoic acid A solution of 4-(dihydroxyboryl)benzoic acid (1.66 g, 10 mmol) andpinacol (12 mmol) in toluene (70 mL) was refluxed in a Dean-Stark apparatus for 16 hours and concentrated. The concentrate was triturated with diethyl ether and filtered to provide the desired product of sufficient purity for subsequent use. Example 3C 4-(cyclohexylamino)-3-nitro-N-(4-(4.4,5,5-tetramethyl-1.3,2-dioxaborolan-2- yl)benzoyl)benzenesulfonamide A room temperature solution of Example 3A (1.24 g, 5.0 mmol), Example 3B (1.50 g, 5.0 mmol), EDCI (1.15 g, 6.0 mmol) and DMAP (124 mg) in dichloromethane (10 mL) was stirred for 16 hours, dUuted with ethyl acetate (100 mL), washed sequentially with 1M HCl (20 mL), water (20 mL), and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 528 (M-H) " . Example 3D N-((4'-bromo(l .1 '-biphenyl)-4-yl)carbonyl)-4-(cyclohexylamino)-3-nitrobenzenesulfonamide A mixture of Example 3C (105 mg, 0.2 mmol), 4-bromo-l-iodobenzene (140 mg, 0.5 mmol), Pd 2 (dba) 3 (18 mg, 0.04 mmol), triphenylarsine (36 mg, 0.12 mmol) and lM Na 2 CO 3 (0.5 mL) in dioxane (4 mL) was heated to 95 °C and stirred for 5 hours. The mixture was diluted with ethyl acetate (50 mL), washed sequentially with 1M HCl (5 mL), water (5 mL), and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 556 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.53 (d, IH), 8.16 (d, IH), 7.95 (d, 2H), 7.91 (dd, IH), 7.68-7.60 (m, 5H), 4.12 (d, IH), 3.67 (m, IH), 2.00-1.31 (m, 10H). Example 4 4-(cyclohexylamino)-N-(4-(lH-mdol-6-yl)benzoyl -3-nitrobenzenesulfonamide Example 4A 4-(lH-indol-6-yl)benzoic acid A mixture of 6-bromoindole (480 mg, 2.45 mmol), 4-(dihydroxyboryl)benzoic acid (406 mg, 2.45 mmol), Pd(dppf)Cl 2 -CH 2 Cl 2 (10 mg, 0.01 mmol), and 2MNa 2 CO 3 (5.6 mL, 11.2 mmol) in a mixture of ethanol (4 mL) and DMF (7 mL) was heated to 100 °C, stirred for 16 hours, filtered, and concentrated. The concentrate was dissolved in ethyl acetate, washed sequentially with 1M H 3 PO 4 , water, and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 5 % methanoPdichloromethane to provide the desired product. MS (ESI(-)) m/e 236 (M-H) " . Example 4B 4-(cyclohexylamino)-N-(4-(lH-indol-6-yl)benzoyl)-3-mtrobenzenesulfonamide The desired product was prepared by substituting Example 4A and Example 3A for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 519 (M+H) ; 1H NMR (300 MHz, DMSO-de) δ 8.67 (m, IH), 7.96 (m, 3H), 7.82 (m, 2H), 7.68 (m, 2H), 7.48 (m, 3H), 6.47 (m, IH), 1.96 (m, 2H), 1.71 (m, 2H), 1.43 (m, 7H). Example 5 N-(4-(4-tert-butylcyclohexyl)benzoyl)-4-(cyclohexylamino)-3-nitrobenzenesulfonamide Example 5A 4-tert-butyl- 1 -cyclohexen- 1 - l trifluoromethanesulfonate A -78 °C solution of 4-tert-butylcyclohexanone (1.54 g, 10 mmol) andN- phenyl(trifluoromethanesulfonamide) (3.75 g, 10.5 mmol) in THF (20 mmol) was treated with 1M NaHMDS in THF (11 mL), warmed to room temperature, filtered through a pad of sUica gel (10 g) with diethyl ether (5 mL), and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 1 % ethyl acetate/hexanes to provide the desired product. Example 5B methyl 4-(4-tert-butyl- 1 -cyclohexen- 1 -ypbenzoate A mixture of Example 5A (286 mg, 1.0 mmol), (4-methoxycarbonylphenyl)-boronic acid (216 mg, 1.2 mmol), Pd(dppf)Cl 2 -CH 2 Cl 2 (37 mg, 0.05 mmol), and cesium fluoride (454 mg, 3.0 mmol) in dioxane (5 mL) was heated to 90 °C, stirred for 16 hours, filtered through a pad of silica gel (10 g) with diethyl ether (5 mL) and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 5% ethyl acetate/hexanes to provide the desired product. Example 5C methyl 4-(4-tert-butylcyclohexyl)benzoate A room temperature mixture of Example 5B (230 mg, 0.84 mmol) and 10% Pd/C (100 mg) in ethyl acetate (5 mL) was stirred under a hydrogen atmosphere for 3 hours, filtered through a pad of sihca gel (10 g) with diethyl ether (10 mL), and concentrated to provide the desired product as a ~2: 1 mixture of diastereomers. MS (DO) m/e 275 (M+H) . Example 5D N-(4-(4-tert-butylcvclohexyl)benzoyl)-4-(cyclohexylamino -3-nitrobenzenesulfonamide A mixture of Example 5C (55 mg, 0.20 mmol) and 1M LiOH (0.3 mL) in THF (2 mL) was heated to 50 °C, stirred for 3 hours, concentrated, dissolved in DMF (0.5 mL), and treated with a mixture of Example 3 A (60 mg, 0.20 mmol), EDCI (96 mg, 0.50 mmol), and DMAP (10 mg) in dioxane (2.0 mL). The mixture was stirred for 16 hours, dUuted with ethyl acetate (50 mL), washed sequentiaUy with 1M HCl (5 mL), water (5 mL), and brine (5 mL), dried (MgSO-i), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel, with 50% ethyl acetate/hexanes to provide a ~2: 1 mixture of diastereomers. MS (ESI(-)) m/e 540 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.63 (2d, IH total), 8.33 (2d, IH total), 7.95 (m, IH), 7.82 and 7.78 (2d, 2H total), 7.45 (m, IH), 7.30 (m, 2H), 3.71 (m, IH), 2.28-0.95 (m, 20 H), 0.86 and 0.75 (2s, 9H total). Example 6 6-(cyclohexylamino)-N-((4'-fluoro(l , 1 '-biphenyl -4-yl)carbonyl)-5-nitro(l . l'-biphenyl)-3- sulfonamide Example 6A 3-bromo-4-(cyclohexylamino)-5-nitrobenzenesulfonamide A room temperature solution of Example 3A (1.81 g, 6.0 mmol) and l,3-dibromo-5,5- dimethylhydantoin (950 mg, 3.3 mmol) in dichloromethane was treated with trifluoracetic acid (796 uL, 9.0 mmol), stirred in darkness for 18 hours, treated with saturated NaHCO 3 , and extracted with diethyl ether. The combined extracts were washed with brine, dried (Na 2 SO 4 ), and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 15% ethyl acetate hexanes to provide the desired product. MS (ESI(-)) m/e 376 (M-H) " . Example 6B ό- cyclohexylamino^-S-nitrod '-biphenyΩ-S-sulfonamide The desired product was prepared by substituting Example 6A and phenylboronic acid for Example 5A and 4-(methoxycarbonylphenyl)boronic acid, respectively, in Example 5B. MS (ESI(-)) m/e 374 (M-H) " . Example 6C 6-(cyclohexylamino -N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-5-nitro( 1.1 '-biphenyl)-3- sulfonamide The desired product was prepared by substituting Example 6B for Example IC in Example ID. MS (ESI(-)) m/e 572 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.66 (d, IH), 7.95 (m, 3H), 7.78 (m, 4H), 7.75 (d, IH), 7.50 (m, 5H), 7.31 (m, 2H), 1.60-1.41 (m, 4H), 1.32 (m, 2H), 1.12-0.96 (m, 2H), 0.75-0.60 (m, 2H). Example 7 N-((4'-fluoro( ' l,r-biphenyl)-4-yl)carbonyl)-3-nitro-4-((trans-2- (phenylsulfanyl)cyclohexyl)-imino benzenesulfonamide Example 7A trans-2-(phenylsulfanyl)cyclohexanol A room temperature solution of cyclohexene oxide (9.81 g, 100 mmol) andN,N- dnsopropylethylamine (2.60 g, 20.0 mmol) in 1,2-dichloroethane (200 mL) was treated with thiophenol (11 g, 100 mmol), stirred for 16 hours, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 20% ethyl acetate/hexanes to provide the desired product. Example 7B ((trans-2-azidocyclohexyl)sulfanyl benzene A 0 °C solution of Example 7A ( 1.04 g, 5.0 mmol) , and N,N-dusopropylethylamine (1.1 mL, 6.5 mmol) in dichloromethane (20 mL) was treated with methanesulfonyl chloride (0.46 mL, 6.0 mmol), warmed to room temperature, stirred for 16 hours, dUuted with hexanes (20 mL), filtered through a pad of silica gel (15 g) with 10 % diethyl ether in hexanes, and concentrated. The concentrate was dissolved in DMF (10 mL), treated with tetrabutylammonium iodide (400 mg, 1.1 mmol), 15-crown-5 (100 mg, 0.40 mmol), and sodium azide (1.0 g, 15.4 mmol), heated to 100 °C, and stirred for 16 hours. The mixture was dUuted with ethyl acetate (100 mL), washed with water (15 mL) and brine (15 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 234 (M+H) + . Example 7C trans-2-(phenylsulfanyl)cyclohexanamine A room temperature solution of Example 7B (777 mg, 3.3 mmol), triphenylphosphine (2.62 g, 10.0 mmol), and water (180 mg, 10 mmol) in THF (5 mL) was stirred for 16 hours and concentrated. The concentrate was purified by flash column chromatography on silica. gel with 50% ethyl acetate/hexanes foUowed by 10% methanol/dichloromethane to provide the desired product. MS (DCI) m/e 208 (M+H) + . Example 7D N-((4'-fluoro(Lr-biphenyl)-4-yl carbonyl)-3-nitro-4-((trans-2- (phenylsulfanyl) cy clohexyl) amino menzenesulfonamide A solution of Example 7C (50 mg, 0.24 mmol), Example ID (50 mg, 0.11 mmol) and 2,6-lutidine (50 mg, 0.47 mmol) in dioxane (5 mL) was heated to reflux, stirred for 16 hours, cooled to room temperature, filtered through a pad of sUica gel (5 g) with 5% methanol/ethyl acetate, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 30-100% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 604 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.54 (d, IH), 8.45 (d, IH), 7.97 (d, 2H), 7.93 (m, IH), 7.78 (m, 3H), 7.44-7.10 (m, 9H), 3.85 (m, IH), 3.61 (m, IH), 2.15-1.30 (m, 8H). Example 8 N-r^'-fluorori.l'-biphenvD^-vDcarbonvn-S-nitro^-rrπS^R ^- (phenylsulfanyl) cyclohexyl) amino)benzenesulfonamide Example 8A (2RS)-2-(phenylsulfanyl)cyclohexanone A -40 °C solution of 2M oxalyl chloride in dichloromethane (10 mL) in dichloromethane (20 mL) was slowly treated with DMSO (3.12 g, 40 mmol), stirred for 30 minutes, treated with Example 7A (1.80 g, 8.6 mmol), stirred for 1 hour, and treated with triethylamine (10.1 g, 100 mmol). The mixture was warmed to room temperature, stirred for 16 hours, dUuted with diethyl ether (100 mL), washed with water (15 mL) and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10-25 % ethyl acetate/hexanes to provide the desired product. MS (DCJJNH 3 ) m/e 224 (M+NE- 4 ) + . Example 8B cis-2-(phenylsulfanyl)cyclohexanamine A room temperature solution of Example 8A (847 mg, 4.1 mmol) and hydroxylamine hydrochloride (1.0 g, 14.4 mmol) in methanol (5 mL) was stirred for 3 hours, diluted with ethyl acetate (50 mL), washed with water (5 mL) and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was treated with IM LAH in THF (5 mL, 5.0 mmol), stirred for 16 hours, carefuUy added to ice cold saturated N--H 2 PO 4 (10 mL), and extracted with ethyl acetate. The combined extracts were washed with brine (20 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 2-5 % methanol dichloromethane to provide the desired product as a 3.3: 1 mixture of cis- and trans- isomers. MS (DCI) m/e 208 (M+H) . Example 8C N-((4'-fluoro(Lr-biphenyl)-4-yl carbonylV3-nitro-4-((cis-2- (phenylsulfanyl) cyclohexyl) amino)benzenesulfonamide Example 8B was processed according to the procedure described in Example 7D to provide a 2: 1 mixture of the desired product and Example 7D. MS (ESI(-) m/e 604 (M-H) " ; ! H NMR (400 MHz, DMSO-d δ ) δ 8.67 (2d, IH total), 8.56 and 8.49 (2d, IH total), 7.97 (dt, IH), 7.91 (dt, IH), 7.78 (m, 3H), 7.38-7.05 (m, 9H), 4.15 (m, IH), 3.90 (m, IH), 2.00-1.20 (m, 8H). Example 9 N-r4-π-cvclohexen-l-yl benzoyl -3-nitro-4-(((lR.2R -2- (phenylsulfanyl cyclohexyl)amino benzenesulfonamide Example 9A methyl 4-( 1 -cyclohexen- 1 -yPbenzoate The desired product was prepared by substituting cyclohexanone for tert- butylcyclohexanone in Examples 5A and 5B. MS (DCI) m/e 217 (M+H + ). Example 9B 4-chloro-N-(4-( 1 -cyclohexen- 1 -ypbenzo yf) -3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 9A and Example IC for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 419 (M-H) " . Example 9C N-(4-( 1-cvclohexen- 1 -yllbenzoyl -3-nitro-4-((( 1R2R 2- (phenylsulfanyl) cyclohexyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 9B for Example ID in Example 7D. MS (ESI(-)) m/e 590 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.51 (d, IH), 8.42 (d, IH), 7.90 (dd, IH), 7.53 (d, 2H), 7.50 (m, 2H), 7.40 (m, IH), 7.20-7.09 (m, 5H), 6.32 (m, IH), 3.85 (m, IH), 3.61 (m, IH), 2.40-1.20 ( , 16H). Example 10 N-(4-( 1 -cyclohexen- 1 -yl)benzoyl)-3-nitro-4-((cis-2- (phenylsulfanyl) cyclohexyl) amino benzenesulfonamide The desired product was prepared by substituting Example 9B and Example 8B for Example ID and Example 7C, respectively, in Example 7D. MS (ESI(-)) m/e 590 (M-H) " ; 1H NMR (400 MHz, DMSO-de) δ 8.69 (d, IH), 8.54 (d, IH), 7.90 (dd, IH), 7.84 (d, 2H), 7.51 (d, 2H), 7.27 (m ,3H), 7.13-7.00 (m, 3H), 6.33 (m, IH), 4.15 (m, IH), 3.90 (m, IH), 2.39 (m, 2H), 2.20 (m, 2H), 1.95 (m, 2H), 1.90-1.20 (m, 10H). Example 11 4-((( 1 S,2S)-2-(benzyloxy)eyclohexyl)ammo)-N-(4-( 1 -cyclohexen- 1 -yl)benzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 9B and (lS,2S)-2- benzyloxycyclohexylamine for Example ID and Example 7C, respectively, in Example 7D. MS (ESI(-)) m/e 588 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.90 (d, IH), 8.55 (d, IH), 8.51 (s, IH), 8.06 (dd, IH), 7.68 (d, 2H), 7.44 (d, 2H), 7.21 (m, 2H), 7.12 (m, 3H), 6.28 (m, IH), 4.61 (d, IH), 4.39 (d, IH), 3.60 (m, IH), 3.35 (m, IH), 2.40 (m, 2H), 2.23 (m, 2H), 1.90-0.80 (m, 12H). Example 12 4-(cycloheptylamino)-N-((4'-fluoro(l,r-biphenyl)-4-yl)c-irbonyl)-3-nitroberιzenesulfonarnide The desired product was prepared by substituting cycloheptylamine for 2,2- dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 512 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.67 (d, IH), 8.39 (d, IH), 7.99 (dd, IH), 7.95 (d, 2H), 7.78 (2d, 4H), 7.32 (t, 2H), 7.23 (d, IH), 3.89 (ddddd, IH), 1.98-1.92 (m, 2H), 1.71-1.52 (m, 10H). Example 13 4-(Y2RSVbicvclo(2.2. llhept-2-ylamino -N- (4'-fluoro( 1 , 1 '-biρhenyl -4-yl carbonyl -3- nitrobenzenesulfonamide A solution of Example ID (50 mg, 0.12 mmol), 2-aminonorbornane hydrochloride (106 mg, 0.58 mmol), and triethylamine (0.08 ml, 0.58 mmol) in DMF (2 mL) were heated to 120 °C in a sealed vial with shaking for 16 hours, then concentrated. The concentrate was dissolved in 1 : l/DMSO:methanol (1.0 ml) and purified by reverse phase preparative HPLC with 0.1 % TFA in H 2 O/CH 3 CN to provide the desired product. MS (APCI(+)) m e 510 (M+H) + ; ! H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.67 (d, IH), 8.48 (d, IH), 7.99 (dd, IH), 7.95 (d, 2H), 7.78 (2d, 4H), 7.32 (t, 2H), 7.24 (d, IH), 4.04 (m, IH), 2.58 (m, IH), 2.27 (m, IH), 2.24-2.21 (m, IH), 1.59-1.29 (m, 6H), 0.97 (dt, IH). . Example 14 N-((4 , -fluoro(l.r-biphenvn-4-yl carbonylV3-nitro-4-(((lR.2R.3R,5S -2,6.6- trimethylbicyclo(3.1. l)hept-3-yl)amino)benzenesulfonamide The desired product was prepared by substituting (lR,2R,3R,5S)-(-)- isopinocampheylamine for 2,2-dimethylcyclpentylamine in Example IE. MS (APCI(+)) m/e 552 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.68 (d, IH), 8.38 (d, IH), 7.98 (dd, IH), 7.96 (d, 2H), 7.79 (2d, 4H), 7.37 (d, IH), 7.32 (t, 2H), 4.07-4.01 (m, IH), 2.76- 2.71 (m, IH), 2.42-2.37 (m, IH), 2.11-2.08 (m, IH), 1.98-1.96 (m, IH), 1.95-1.86 (m, IH), 1.67-1.63 (m, IH), 1.24 (s, 3H), 1.13 (d, 3H), 1.08 (s, 3H), 1.07 (s, IH). Example 15 N-rr4'-fluoro( ' Ll'-biphenyl)-4-yl carbonyl -3-nitiO-4-r(;( iR.2R.4R -1.7.7- trimethvfbicy clo(2.2.1 )hept-2-yl) amino)benzenesulfonamide The desired product was prepared by substituting (R)-(+)-bornylamine for 2,2- dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 569 (M+NPL;)*; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.55 (br s, IH), 8.73 (d, IH), 8.70 (d, IH), 7.98 (dd, IH), 7.97 (d, 2H), 7.80 (2d, 4H), 7.34 (t, 2H), 7.31 (d, IH), 3.98-3.95 (m, IH), 2.58-2.54 (m, IH), 1.82- 1.68 (m, 3H), 1.58-1.51 (m, IH), 1.29-1.25 (m, IH), 1.02 (s, 3H), 0.98 (dd, IH), 0.94 (s, 3H), 0.90 (s, 3H). Example 16 N-.ϊ4'-fluorof 1 , 1 '-biphenyl -4-vncarbonvn-3-nitro-4-((( 1 S.2S.4SV 1,7,7- trimethylbicyclo(2.2.1 hept-2-yl amino)benzenesulfonamide (S)-(-)-Bomylamine was processed according to the procedure described in Example IE to provide the desired product. MS (DC1/NH 3 ) nVe 569 (M+NH 4 ) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.71 (d, IH), 8.67 (t, IH), 7.98 (dd, IH), 7.95 (d, 2H), 7.78 (2d, 4H total), 7.32 (t, 2H), 7.28 (2d, IH total), 3.97-3.91 and 3.70-3.66 (2m, IH total), 2.56- 2.50 (m, IH), 2.06-0.95 (m, 6H), 1.01 and 1.00 (2s, 3H total), 0.95 and 0.91 (2s, 3H total), 0.88 and 0.87 (2s, 3H total). Example 17 N-r4-r2-methyl-L3-benzothiazol-5-yl benzovn-3-nitro-4-(((;iS.2S.4S - 7.7- trimethylbicyclo(2.2.1)hept-2-yl)amino)benzenesulfonamide Example 17A 4-(2-methyl-l .3-benzothiazol-5-yl)benzoic acid The desired product was prepared by substituting 5-bromo-2-methyl-l,3- benzothiazole for 6-bromoindole in Example 4A. MS (DCI) m/e 270 (M+H) + . Example 17B 3-nitro-4-(((lS,2S,4S)-l,7,7-trimethylbicyclo(2.2.1)hept-2-yl amino)benzenesulfonamide The desired product was prepared by substituting (S)-(-)-bornylamine for cyclohexylamine in Example 3 A. MS (ESI(-)) m/e 352 (M-H) " ; Example 17C N-r4-r2-methyl-1.3-benzothiazol-5-yl)benzoyl -3-nitro-4-r(αS.2S.4S -1.7.7- trimethylbicyclo(2.2.1)hept-2-yl)amino)benzenesulfonamide The desired product was prepared by substituting Example 17A and Example 17B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 603 (M-H) " ; 2 H NMR (300 MHz, DMSO-dβ) δ 8.72 (d, IH), 8.68 (d, IH), 8. 26 (d, IH), 8.14 (d, IH), 7.98 (m, 3H), 7.89 (d, 2H), 7.77 (dd, IH), 7.30 (d, IH), 3.94 (m, IH), 2.82 (s, 3H), 1.82-1.64 (m, 3H), 1.54 (m, IH), 1.25 (m, 2H), 1.00 (s, 3H), 0.92 (m, IH), 0.91 (s, 3H), 0.89 (s, 3H).. Example 18 4-( 1 -adamantylamino)-N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 1-adamantanamine for 2,2- dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 550 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.68 (d, IH), 8.48 (s, IH), 7.96 (d, 2H), 7.95 (dd, H), 7.78 (2d, 4H), 7.58 (d, IH), 7.32 (t, 2H), 2.13-2.08 (m, 9H), 1.76-1.60 (m, 6H). Example 19 N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3-nitro-4-(2-phenoxyanilino)benzenesulfonamide Example 19A 3-nitro-4-(2-phenoxyanilino)benzenesulfonamide A -78 °C solution of Example IC (236 mg, 1.0 mmol) and 2-phenoxyaniline (370 mg, 2.0 mmol) in THF (10 mL) was treated with IM lithium hexamethyldisilazide in THF (4 mL, 4.0 mmol), warmed to room temperature over 4 hours, diluted with ethyl acetate (50 mL), washed sequentially with IM HCl (5 mL), water (5 mL), and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 10-30 % ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 384 (M-H) " . Example 19B N-((4'-fluoro( 1 , 1 '-biphenylV4-yl)carbonyl)-3 -mtro-4-(2-phenoxyanilino benzenesulfonamide The desired product was prepared by substituting Example 19A for Example IC in Example ID. MS (ESI(-)) m/e 582 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 9.74 (s, IH), 8.63 (d, IH), 7.97 (m, 3H), 7.79 (m, 4H), 7.52 (dd IH), 7.40-7.20 (m, 6H), 7.14-7.00 (m, 3H), 6.83 (m, 2H). Example 20 N-((4'-fluoro( 1.1 '-biphenyl)-4-yl carbonyl -3 -nitro-4-(2- (phenylsulfanyl)anUino benzenesulfonamide Example 20A 2-(phenylsulfanyl)aniline A room temperature solution of 2-fluoronitrobenzene (1.41 g, 10.0 mmol), thiophenol (1.21 g, 11.0 mmol), and triethylamine (2 mL) in THF (20 mL) was stirred for 16 hours, treated with 3M HCl (10 mL) and tin(II) chloride dihydrate (11.4 g, 50 mmol), stirred for 4 hours, and extracted with ethyl acetate (50 mL). The combined extracts were dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 50% hexanes/dichloromethane to provide the desired product. MS (DCI) m/e 202 (M+H) + . Example 20B 3-nitro-4-(2-(phenylsulfanyl)anilino)benzenesulfonamide The desired product was prepared by substituting Example 20A for 2- phenyoxyaniline in Example 19A. MS (ESI(-)) m/e 400 (M-H) " . Example 20C N-((4'-fluoro( 1 , 1 '-biphenyι)-4-yl)carbonyl)-3 -nitro-4-(2- (phenylsul fanyl) anilinolbenzenesulfonamide The desired product was prepared by substituting Example 20B for Example IC in Example ID. MS (ESI(-)) m/e 598 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 9.91 (s, IH), 8.68 (d, IH), 7.97 (d, 2H), 7.93 (dd, IH), 7.81 (m, 4H),7.49 (m, 2H), 7.41-7.23 (m, 8H), 7.17 (m, lH), 6.97 (d, IH). Example 21 4-((cyclohexyhnethyl)amino -N-((2'-methoxyπ , 1 '-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide Example 21 A 2'-methoxy(l , 1 '-biphenyP -carboxylic acid The desired product was prepared by substituting 2-methoxyphenylboronic acid for 4- methoxyphenylboronic acid in Example 31 A. MS (APCI(+)) m/e 246 (M+NH- 4 ) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.89 (br s, IH), 7.96 (d, 2H), 7.60 (d, 2H), 7.39 (ddd, IH), 7.33 (dd, IH), 7.14 (dd, IH), 7.05 (dt, IH), 3.78 (s, 3H). Example 21B 4-((cyclohexylmethyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting cyclohexylmethylamine for cyclohexylamine in Example 3A. MS (DCI) m/e 314 (M+H) + . Example 21 C 4-((cyclohexylmethyl amino)-N-((2'-methoxy(l .1 '-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 21 A and Example 21 B for Example IB and Example IC, respectively, in Example ID. MS (APCI(+)) m/e 524 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.66 (d, IH), 8.63 (t, IH), 7.96 (dd, IH), 7.90 (d, 2H), 7.57 (d, 2H), 7.38 (dt, IH), 7.31 (dd, IH), 7.26 (d, IH), 7.13 (d, IH), 7.04 (t, IH), 3.76 (s, 3H), 3.36-3.26 (m, 2H), 1.76-1.61 (m, 6H), 1.23-1.12 (m, 3H), 1.04-0.96 (m, 2H). Example 22 4-((cyclohexylmethyl)amino -N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 2 IB for Example IC in Example ID. MS (ESI(-)) m/e 510 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.68 (d, IH); 7.94 (m, 3H), 7.82-7.74 (m, 4H), 7.36-7.26 (m, 3H), 3.16 (t, IH), 1.80-1.50 (m, 6H), 1.30- 0.90 (m, 6H). Example 23 N-((4'-chloro-3'-(trifluoromethoxy)(l, -biphenyl)-4-yl)carbonyl)-4- ((cyclohexylmethyl)amino)-3-nitrobenzenesulfonamide Example 23A 4-bromo- 1 -chloro-2-(trifluoromethoxy)benzene A mixture of tert-butyl nitrite (1.78 mL, 15.0 mmol), copper (II) chloride (1.61 g, 12.0 mmol) and 4-bromo-2-(trifluoromethoxy)aniline (2.56 g, 10.0 mmol) in acetonitrUe (40 mL) was heated to 70 °C, stirred for 3 hours, cooled to room temperature, poured into 0.5M HCl, and extracted with diethyl ether. The combined extracts were washed with water and brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (ESI(+)) m/e 275 (M+H) + . Example 23B 4'-chloro-3'-(trifluoromethoxy)( 1.1 '-biphenyl)-4-carboxyHc acid The desired product was prepared by substituting Example 23A for 6-bromoindole in Example 4A. MS (ESI(-)) m/e 315 (M-H) " . Example 23 C N-((4'-chloro-3'-(trifluoromethoxy (l,l'-biphenyl)-4-yl)carbonyl)-4- ((cyclohexylmethyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 23B and Example 2 IB for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 610 (M-H) " ; 1H NMR (300 MHz, DMSO-d δ ) δ 8.66 (m, 2H), 7.92 (m, 7H), 7.27 (m, IH), 3.32 (m, 2H), 1.70 (m, 6H), 1.19 (m, 3H), 1.02 (m, 2H). Example 24 4-((cyclohexyhnethyl)amino)-N-(4-(lH-indol-6-yl benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 4A and Example 2 IB for Example IB and Example IC in Example ID. MS (ESI(-)) m/e 531 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.64 (m, IH), 7.95 (m, 3H), 7.78 (m, 2H), 7.70 (m, IH), 7.63 (m,lH), 7.42 (m, IH), 7.38 (m,lH), 7.24 (m, IH), 6.48 (m, IH), 3.23 (m, 2H), 1.70 (m, 8H), 1.21 (m, IH), 1.01 (m, 2H). Example 25 4-((cyclohexylmethyl) amino)-N-(4-(2-methyl- 1 , 3 -benzothiazol-5-yl benzoyl)-3 - nitrobenzenesulfonamide The desired product was prepared by substituting Example 17A and Example 21B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 563 (M-H) " ; 1H NMR (400 MHz, DMSO-dg) δ 8.69 (d, IH), 8.65 (t, IH), 8.26 (s, IH), 8.14 (d, IH), 7.98 (m, 3H), 7.90 (d, 2H), 7.77 (dd, IH), 7.28 (d, IH), 3.30 (t, 2H), 2.82 (s, 3H), 1.80-1.60 (m, 6H), 1.40-0.95 (m, 5H). Example 26 4-((cyclohexylmethyl)amino)-N-((4'-fluoro(Lr-biphenyl)-4-yl)carbonyl)-3-nitro-5-(2- pyrimidinyDbenzenesulfonamide Example 26A 3-bromo-4-((cyclohexylmethyl)amino)-5-nitrobenzenesulfonamide The desired product was prepared by substituting Example 2 IB for Example 3 A in Example 6A. MS (ESI(+)) m/e 392 (M+H) + . Example 26B 4-((cyclohexylmethyDamino -3-mtro-5-(2-pyrimidinyl benzenesulfonamide A solution of Example 26A (270 mg, 0.69 mmol), 2-(tributylstannyl)pyrimidine (305 uL, 0.83 mmol), Pd 2 (dba) 3 (32 mg, 0.034 mmol), and tris-(2-furyl)ρhosρhine (32 mg, 0.10 mmol) in acetonitrUe (2 mL) was heated to reflux for 48 hours and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(+)) m/e 392 (M+H) . Example 26C 4-((cyclohexylmethyl)amino)-N-((4'-fluoro(l , 1 '-biphenyl)-4-yl)carbonyl)-3-rjitro-5-(2- pyrimidinyl)benzenesulfonamide The desired product was prepared by substituting Example 26B for Example 1 C in Example ID. MS (ESI(+)) m/e 590 (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 8.04-7.90 (m, 4H); 7.82-7.70 (m, 6H), 7.31 (m, 2H), 7.05 (dd, IH), 2.73 (t, 2H), 1.70-1.53 (m, 6H), 1.52 (m, IH), 1.16-1.07 (m, 2H), 0.92-0.79 (m, 2H). Example 27 N-((4'-fluoroπ , 1 '-biphenyl -4-yl carbonyl -3-nitro-4-(((cis-2- (phenylsulfanyl cvclohexyl)methyl)amino)benzenesulfonamide Example 27A N-((4'-fluoro(l.r-biphenyl)-4-yl)carbonyl)-4-(((ttans-2-hydroxycyclohexyl)methyl)amino)- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example ID and trans-2-methyl- aminocyclohexanol for Example IC and cyclohexylamine, respectively, in Example 3 A. MS (ESI(+)) m/e 528 (M+H) + . Example 27B N-ff4'-fluoro(l '-biphenyl)-4-yl)carbonyl)-3-nitro-4-(((cis-2- (phenylsulfanyl) cyclohexyl)methyl) amino)benzenesulfonamide A room temperature solution of tri-n-butylphosphine (90 μL, 0.36 mmol) and 1,1'- (azodicarbonyl)dipiperidine (91 mg, 0.36 mmol) in THF (4 mL) was treated with Example 27A (90 mg, 0.17 mmol) and thiophenol (21 mg, 0.19 mmol), stirred for 18 hours, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 618 (M-H) " ; ! H NMR (300 MHz, DMSO-dg) δ 8.61 (d, IH), 7.94 (m, 2H), 7.90 (d, IH), 7.73 (m, 2H), 7.68-7.55 (m, 7H), 7.29 (d, 2H), 6.87 (d, IH), 3.44 (m, 2H), 1.59 (m, 4H), 1.37 (m, 4H), 0.89 (m, 2H). Example 28 4-((l-adamantylmιethyl)amino)-N-(4-iodobenzoyl)-3-nitrobenzenesulfonamide Example 28A 4-((l-adamantylmethyl)aminoVN-(4-iodobenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting 1-adamantylmethylamine for cyclohexylamine in Example 3 A. MS (DCI) m/e 366 (M+H) . Example 28B 4-((l-adamantylmethyl amino)-N-(4-iodobenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting 4-iodobenzoic acid and Example 28A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 594 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.51 (d, IH), 8.40 (t, IH), 7.87 (dd, IH), 7.72- 7.62 (q, 4H), 7.16 (d, IH), 3.12 (d, 2H), 1.97 (m, 2H), 1.72-1.54 (m, 13H). Example 29 4-(( 1 -adamantylmethyl)amino)-N-(4-(2-chloro-3-thienyl benzoyl)-3- nitrobenzenesulfonamide Example 29A 4-(2-chloro-3-thienyl)-benzoic acid SoHd Pd(PPh 3 ) 4 (11.0 mg, 0.01 mmol) was treated with a room temperature solution of 2-bromo-5-chlorothiophene (143 mg, 0.72 mmol) in DME (4 mL), stirred for 5 minutes, treated with a solution of 4-(dihydroxyboryl)benzoic acid (100 mg, 0.60 mmol) in DME (2 mL), and stirred for 5 minutes. The mixture was treated with 2M Na 2 CO 3 (1.5 mL, 3.0 mmol), heated to 75 °C, stirred for 18 hours, cooled to room temperature, filtered, triturated with water (3 mL), and concentrated. The concentrate was treated with boUing water (4 mL), filtered through cehte, cooled to room temperature, adjusted to pH<7 with HCl, and filtered to provide the desired product. MS (APCI(+)) m e 239 (M+H) + . Example 29B 4-((l-adamantylmethyl)amino)-N-(4-(2-chloro-3-thienyl)benzoyl)-3- nitrobenzenesulfonamide A room temperature mixture of Example 29A (39.4 mg, 0.17 mmol), resin-bound dicyclohexylcarbodiimide (225.0 mg, 1.83 mmol/g), and dimethylaminopyridine (60.0 mg, 4.95 mmol) was treated with a solution of Example 28A (40 mg, 0.11 mmol) in a 1: 1 mixture of 1,2-dichloro ethane and 2-methyl-2-propanol (3 mL), and agitated overnight on an Argonaut Technologies Quest 210. The mixture was treated with resin bound p-TsOH (990 mg, 1.44 mmol/g), agitated for 1 hour, decanted, and washed with dichloromethane. The combined extracts were concentrated and purified by HPLC using 0.1 % TFA in H 2 O/CH 3 CN to provide the desired product. MS (APCI(+)) m/e 586 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 12.50 (s, IH), 8.66 (d, IH), 8.57 (t, IH), 7.96 (d, 2H), 7.95 (dd, IH), 7.71 (d, 2H), 7.59 (d, IH), 7.36 (d, IH), 7.29 (d, IH), 7.29 (d, IH), 3.17 (d, 2H), 1.97 (s, 3H), 1.58 (m, 12H). Example 30 4-(( 1 -adamantylmethyl)amino -N-(( 1 , 1 '-biphenyl)-4-ylc-ιrbonyl)-3-rutrobenzenesulfonamide The desired product was prepared by substituting (l,l'-biphenyl) carboxy lie acid for Example 29A in Example 29B. MS (APCI(+)) m/e 546 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 12.46 (s, IH), 8.68 (d, IH), 8.58 (t, IH), 7.96 (d, 2H), 7.95 (dd, IH), 7.80 (d, 2H), 7.73 (d, 2H), 7.50 (t, 2H), 7.42 (t, IH), 7.37 (d, IH), 3.17 (m ; 2H), 1.97 (s, 3H), 1.58 (m, 12H). Example 31 4-(( 1 -adamantylmethyl)amino)-N-((4'-methyl( 1 , 1 '-biphenyl)-4-yl) carbonyι)-3- nitrobenzenesulfonamide Example 31 A 4'-methyl( 1 , 1 '-biphenyl)-4-carboxylic acid A room temperature solution of ethyl 4-bromobenzoate (0.70 mL, 4.3 mmol) in DME (20 mL) was treated with Pd(PPh 3 ) 4 (246 mg, 0.2 mmol), stirred for 5 minutes, treated with a solution of 4-methylphenylboronic acid (870 mg, 6.4 mmol) in ethanol (10 mL), stirred for 5 minutes, treated with 2M Na 2 CO 3 (18.0 mL, 36.0 mmol), heated to reflux, stirred for 16 hours, and concentrated. The concentrate was dissolved in water (75 mL) and diethyl ether (50 mL), filtered through cehte, and extracted with diethyl ether. The combined extracts were washed with brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 33% acetone/hexanes. The resulting product was dissolved in methanol (10 mL) and THF (5 mL), treated with IM NaOH (4.3 mL, 4.3 mmol), stirred for 48 hours, concentrated, dissolved in water (10 mL), adjusted to pH 1 with 12M HCl, and filtered. Recrystallization from ethyl acetate provided the desired product. MS (APCI(+)) m/e 213 (M+H) + . Example 3 IB 4-((T -adamantylmethyl)amino)-N-((4'-methyl( 1 , 1 '-biphenyD-4-yl) carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 31 A for Example 29A in Example 29B. MS (APCI(+)) m/e 560 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.44 (s, IH), 8.67 (d, IH), 8.57 (t, IH), 7.95 (dd, IH), 7.94 (d, 2H), 7.77 (d, 2H), 7.63 (d, 2H), 7.36 (d, IH), 7.30 (d, 2H), 3.17 (d, 2H), 2.35 (s, 3H), 1.97 (s, 3H), 1.58 (m, 12H). Example 32 4-(( 1 -adamantylmethyl amino)-N-((4'-ethyl( 1 , 1 '-biphenvD-4-yl carbonyD-3- nitrobenzenesulfonamide Example 32A 4'-ethyl( 1 , 1 '-biphenyl)-4-carboxylic acid The desired product was prepared by substituting l-bromo-4-ethylbenzene for 2- bromo-5-chlorothioρhene in Example 29A. MS (APCI(-)) m/e 225 (M-H) " . Example 32B 4-((l-adamantyιmethyl)amino)-N-((4'-ethyl(l, -biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 32A for Example 29 A in Example 29B. MS (APCI(+)) m/e 574 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (s, IH), 8.67 (d, IH), 8.57 (t, IH), 7.95 (dd, IH), 7.94 (d, 2H), 7.77 (d, 2H), 7.65 (d, 2H), 7.36 (d, IH), 7.32 (d, 2H), 3.17 (d, 2H), 2.65 (q, 2H), 1.97 (s, 3H), 1.58 (m, 12H), 1.20 (t, 3H). Example 33 4-(π-adamantylmethyl amino)-3-nitro-N-((4'-propyl(l .1 '-biphenyl)-4- yl carbonyl)benzenesulfonamide Example 33 A 4'-propyl( 1.1 '-biphenyl)-4-carboxylic acid The desired product was prepared by substituting l-bromo-4-propylbenzene for 2- bromo-5-chlorothioρhene in Example 29 A. MS (APCI(-)) m/e 239 (M-H) " . Example 33B 4-(( 1 -adamantylmethyl amino)-3-nitro-N-((4'-propyl( 1 , 1 '-biphenyl -4- yl) carbonyl)benzenesulfonamide The desired product was prepared by substituting Example 33 A for Example 29A in Example 29B. MS (APCI(+)) m/e 588 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.43 (s, IH), 8.67 (d, IH), 8.57 (t, IH), 7.95 (dd, IH), 7.94 (d, 2H), 7.77 (d, 2H), 7.64 (d, 2H), 7.36 (d, IH), 7.30 (d, 2H), 3.18 (d, 2H), 2.60 (t, 2H), 1.97 (s, 3H), 1.58 (m, 14H), 0.90 (t, 3H). Example 34 4-((l-adamantylmethyl)amino)-N-((3'-chloro(l,r-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide Example 34A 3 '-chloro- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting 3-chlorophenylboronic acid for 4- methylphenylboronic acid in Example 31 A. Example 34B 4-(( 1 -adamantylmethyl)amino)-N-((3 '-chloro( 1 , 1 '-biphenyl)-4-yl) carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 34A for Example 29A in Example 29B. MS (APCI(+)) m/e 580 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.57 (t, IH), 8.57 (t, IH), 7.96 (d, 2H), 7.95 (d, IH), 7.83 (d, 2H), 7.80 (t, IH), 7.70 (dt, IH), 7.50 (m, 2H), 7.36 (d, IH), 3.18 (m, 2H), 1.97 (s, 3H), 1.58 (m, 12H). Example 35 N-((3'-acetyl(l,r-biphenyl)-4-yl)carbonyl)-4-((l-adamantylmethyl amino)-3- nitrobenzenesulfonamide Example 35A 3 '-acetyl( 1.1 '-biphenyl)-4-carboxyUc acid The desired product was prepared by substituting l-(3-bromophenyl)ethanone for 2- bromo-5-chlorothiophene in Example 29A. MS (APCI(-)) m/e 239 (M-H) " . Example 35B N-((3'-acetyl(l .1 '-biphenyl -4-yl)carbonyl)-4-(( 1 -adamantylmethyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 35A for Example 29A in Example 29B. MS (APCI(+)) m/e 588 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.68 (d, IH), 8.57 (t, IH), 8.24 (t, IH), 7.99 (d, 4H), 7.95 (dd, IH), 7.88 (d, 2H), 7.64 (t, IH), 7.36 (d, IH), ), 3.17 (m, 2H), 2.66 (s, 3H), 1.97 (s, 3H), 1.58 (m, 12H). Example 36 4-((l-adamantylmethyl)amino -N-((4'-chloro(l '-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide Example 36A 4'-chloro( 1 , 1 '-biphenyl)-4-carboxylic acid The desired product was prepared by substituting 4-chlorophenylboronic acid for 4- ethylphenylboronic acid in Example 31 A. MS (APCI(-)) m/e 231 (M-H) " . Example 36B 4-((l-adamantylmethyl amino)-N-((4'-chloro(l,r-biphenyl)-4-yl)carbonyl -3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 36A for Example 29A in Example 29B. MS (APCI(+)) m/e 580 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.57 (t, IH), 7.95 (m, 3H), 7.80 (d, 2H), 7.77 (d, 2H), 7.54 (d, 2H), 7,36 (d, IH), 3.17 (d, 2H), 2.66 (s, 3H), 1.97 (s, 3H), 1.58 (m, 12H). Example 37 4-(π-adamantylmethyl amino -N-((3'.4'-dichloro(l.r-biρhenyl -4-yl ' )carbonyl)-3- nitrobenzenesulfonamide Example 37A 3 ',4'-dichloro( 1 , 1 '-biphenyl)-4-carboxylic acid The desired product was prepared by substituting 4-bromo- 1 ,2-dichlorobenzene for 2- bromo-5-chlorothiophene in Example 29A. MS (APCI(-)) m/e 265 (M-H) " . Example 37B 4-((l-adamantylmethyl)ammo)-N-((3'.4'-dichloro(l,r-biphenyl -4-yl)carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 37A for Example 29A in Example 29B. MS (APCI(+)) m/e 614 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.57 (t, IH), 7.94 (m, 3H), 7.85 (d, 2H), 7.74 (m, 2H), 7.36 (d, IH), 3.17 (d, 2H), 1.97 (s, 3H), 1.58 (m, 12H). Example 38 4-((l-adamantylmethyl amino)-N-((4'-methoxy(l,r-biphenyl -4-yl)carbonyl -3- nitrobenzenesulfonamide Example 38A 4'-methoxy(l .1 '-biphenyl)-4-carboxylic acid The desired product was prepared by substituting 1 -bromo-4-methoxybenzene for 2- bromo-5-chlorothiophene in Example 29A. MS (APCI(-)) m/e 227 (M-H) " . Example 38B 4-(( 1 -adamantylmethyl amino -N-((4'-methoxy(L 1 '-biphenyl)-4-yl carbonyl -3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 38A for Example 29A in Example 29B. MS (APCI(+)) m/e 576 (M+H) + ; 1H NMR (500 MHz, DMSO-dg) δ 8.67 (d, IH), 8.57 (t, IH), 7.94 (dd, IH), 7.92 (d, 2H), 7.74 (d, 2H), 7.69 (d, 2H), 7.36 (d, IH), 7.00 (d, 2H), 3.80 (s, 3H), 3.18 (d, 2H), 1.97 (s, 3H), 1.58 (m, 12H). Example 39 4-((l-adamantylmethyl)amino)-N-((4'-fluoro( r-biphenyl)-4-yl)carbonyl -3- nitrobenzenesulfonamide The desired product was prepared by substituting 1-adamantanemethylamine for 2,2- dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 581 (M+NfL;) ; H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.67 (d, IH), 8.57 (t, IH), 7.95 (m, 3H), 7.78 (2d, 4H), 7.36 (d, IH), 7.32 (t, 2H), 3.18 (d, 2H), 1.97 (s, 3H), 1.70-1.60 (m, 12H). Example 40 N-((4'-acetyl( 1.1 '-biphenyl)-4-yl)carbonyl) -4-(( 1 -adamantylmethyl)amino)-3- nitrobenzenesulfonamide Example 40A 4'-acetyl( 1 , 1 '-biphenyl)-4-carboxyHc acid The desired product was prepared by substituting l-(4-bromophenyl)ethanone for 2- bromo-5-chlorothiophene in Example 29 A. MS (APCI(-)) m/e 239 (M-H) " . Example 40B N-((4'-acetyl( 1 , 1 '-biphenyl)-4-yl)carbonyl)-4-(( 1 -adamantylmethyl)amino)-3 - nitrobenzenesulfonamide The desired product was prepared by substituting Example 40A for Example 29A in Example 29B. MS (APCI(+)) m/e 588 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.57 (t, IH), 8.05 (d, 2H), 7.99 (d, 2H), 7.95 (dd, IH), 7.88 (t, 4H), 7.36 (d, IH), 3.18 (m, 2H), 2.60 (s, 3H), 1.97 (s, 3H), 1.58 (m, 12H). Example 41 4-(( l-adamantylmethyl)amino)-N-((2'.3'-dimethyl( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide Example 41 A 2',3 '-dimethyK 1 , 1 '-biphenyl)-4-carboxylic acid The desired product was prepared by substituting l-bromo-2,3-dimethylbenzene for 2-bromo-5-chlorothiophene in Example 29A. MS (APCI(-)) m/e 225 (M-H) " . Example 4 IB 4-(( 1 -adamantylmethyl amino)-N-((2',3 '-dimethyl( 1 , 1 '-biphenyl)-4-yl)carbonyι)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 41 A for Example 29A in Example 29B. MS (APCI(+)) m/e 574 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.62 (d, IH), 8.56 (m, IH), 7.89 (m, 3H), 7.36 (m, 3H), 7.15 (m, 2H), 6.96 (d, IH), 3.14 (d, 2H), 2.25 (s, 3H), 2.03 (s, 3H), 1.92 (s, 3H), 1.58 (m, 12H). Example 42 4-(( 1 -adamantylmethyl)amino -N-((4'-fluoro-2'-nitro( 1 , 1 '-biphenyι)-4-yl)carbonylV3 - nitrobenzenesulfonamide Example 42A methyl 4'-fluoro-2'-nitro(l,l'-biphenyl)-4-carboxylate The desired product was prepared by substituting l-bromo-4-fluoro-2-nitrobenzene for Example 5A in Example 5B. MS (DCI) m/e 276 (M+H) + . Example 42B 4-((l-adamantylmLethyl)amino -N-((4'-fluoro-2'-nitro(l,r-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide The procedure used in Example 5 was used here to convert the products from Examples 42A and 28A to the title compound. MS (ESI(-)) m/e 607 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.58 (t, IH), 8.07 (dd, IH), 7.94 (m, 3H), 7.71 (dt, IH), 7.63 (d, IH), 7.46 (d, 2H), 7.36 (d, IH), 3.18 (d, 2H), 1.99 (m, 3H), 1.75-1.50 (m, 12H). Example 43 4-(( 1 -adamantylmethyl amino VN-((2'-amino-4 '-fluoro( 1 , 1 '-biphenyl) -4-yD carbonyl)-3 - nitrobenzenesulfonamide Example 43A methyl 2'-amino-4'-fluoro(l.1 '-biphenyl)-4-carboxylate The desired product was prepared by substituting Example 42 A for Example 5B in Example 5C. MS (DCI) m/e 246 (M+H) + . Example 43B 4-((l-adamantylrnethyl)amino -N-((2'-amino-4'-fluoro(l,r-biphenyl -4-yl carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 43A and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 577 (M-H) " ; H NMR (400 MHz, DMSO-de) δ 8.60 (t, IH), 7.94 (m, 3H), 7.50 (d, 2H), 7.38 (d, IH), 7.00 (dd, IH), 6.55 (dd, IH), 6.42 (dt, IH), 5.22 (br s, 2H), 3.17 (d, 2H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 44 4-((l-adamantylmethyl amino)-N-((4'-fluoro-2'-(methylaminoX r-biphenyl)-4- yl)carbonyl)-3-nitrobenzenesulfonamide Examples 44A and 44B methyl 4'-fluoro-2'-(methylamino ( 1 '-biphenyl)-4-carboxylate and methyl 2 l -(dimethylamino)-4'-fluoro(l .1 '-biphenyD-4-carboxylate A room temperature suspension of sodium hydride (31 mg, 1.3 mmol) in THF (2 mL) was treated sequentiaUy with a solution of Example 44A (123 mg, 0.50 mmol) in THF (2 mL) and methyl iodide (144 mg, 1.0 mmol), stirred for 1 hour, diluted with ethyl acetate (50 mL). washed sequentially with IM HCl (5 mL), water (5 mL), and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 70:25:5/hexanes:dichloromethane:ethyl acetate to provide the desired products. Example 44C 4-(( 1 -adamantylmethyl amino)-N-((4'-fluoro-2'-(methylamino)( 1 , 1 '-biphenyl)-4- yl carbonyl -3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 44A and Example 28A for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 591 (M-H) " ; ! H NMR (400 MHz, DMSO-dg) δ 8.67 (d, IH), 8.57 (t, IH), 7.94 (m, 3H), 7.45 (d, 2H), 7.36 (d, IH), 6.97 (dd, IH), 6.40 (m, 2H), 5.19 (br s, IH), 3.18 (d, 2H), 2.63 (d, 3H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 45 4-(Y 1 -adamantylmethyl)amino)-N-((2'-(dimethylamino -4'-fluoro( 1 , 1 '-biphenyl)-4- yl)carbonyl -3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 44B and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m e 605 (M-H) " ; 1H NMR (400 MHz, DMSO-de) δ 8.60 (d, IH), 8.50 (t, IH), 7.92 (m, 3H), 7.52 ( , 2H), 7.28 (m, IH), 7.18 (dd, IH), 6.81 (m, 2H), 3.17 (d, 2H), 2.46 (s, 6H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 46 4-((((4-((l-adarnantyhnethyl)amino -3-nitrophenyl)sulfonyl)amino carbonyl)-4'-fl ((methoxycarbonyl)amino)-l , 1 '-biphenyl A room temperature solution of Example 43B (30 mg, 0.051 mmol), methyl chloroformate (0.05 mL, 0.65 mmol), N,N-dusopropylethylamine (0.1 mL, 0.57 mmol) and DMAP (3 mg, 0.02 mmol) in dichloromethane (1 mL) was stirred for 16 hours, treated with 4M HCl (0.3 mL), and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50-100 % ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 635 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.89 (br s, IH), 8.65 (d, IH), 8.56 (t, IH), 7.92 (m, 3H), 7.43 (d, 2H), 7.35 (m, 3H), 7.12 (dt, IH), 3.50 (s, 3H), 3.18 (d, 2H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 47 4-((l-adamantylmethyl)amino)-N-((2'-((((Hmethylamino)carbonyl amino -4'-fluoro(l '- biphenyl)-4-yl)carbonyl)-3-nitrobenzenesulfonamide Example 47A methyl 2'-(((dimethylamino)carbonyl)amino -4'-fluoro(l .1 '-biphenyl)-4-carboxylate A room temperature solution of Example 43A (100 mg, 0.41 mmol) in dichloromethane (2 mL) was treated with 1.9M phosgene in toluene (0.26 mL) and N,N- dnsopropylethylamine (0.2 mL, 1.2 mmol), stirred for 16 hours, treated with 2M dimethylamine in THF (0.5 mL), stirred for 1 hour, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. Example 47B 4-(( 1 -adamantyhnethyl)amino)-N-((2'-(((dimethylamino)carbonyl)amino -4'-fluoro( 1,1'- biphenyl)-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 47A and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(+)) m/e 650 (M+H) ; ! H NMR (400 MHz, DMSO-de) δ 8.67 (d, IH), 8.59 (t, IH), 7.95 (dd, IH), 7.91 (d, 2H), 7.78 (s, IH), 7.50 (d, 2H) 7.42 (dd, IH), 7.37 (d, IH), 7.31 (dd, IH), 7.05 (dt, IH), 3.18 (d, 2H), 2.75 (s, 6H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 48 N-(4'-((((4-((l-adamantylmethyl)amino)-3-nitrophenyl)sulfonyl)amino)carbonyl)-4- fluoro( 1 , 1 '-biphenyl)-2-yl)-4-morphohnecarboxamide The desired product was prepared by substituting morphohne for dimethylamine in Example 47. MS (ESI(-)) m/e 690 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.66 (d, IH), 8.57 (t, IH), 8.20 (br s, IH), 7.92 (m, 3H), 7.46 (d, 2H), 7.47-7.24 (m, 4H), 7.08 (dt, IH), 3.47 (m, 4H), 3.24 (m, 4H), 3.18 (d, 2H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 49 N-(4'-((((4-((l-adamantylmethyl arnino)-3-nitrophenyl)sulfonyl)amino)carbonyl)-4- fluoro(l,r-biphenyl)-2-yl -3-aminopropanamide Example 49A 4-((((4-((l-adarrantylmethyl)amm^ butoxycarbonyi) amino propanoyl)amino)-4'- fluoro- 1.1 '-biphenyl A room temperature solution of Example 43 (25 mg, 0.04 mmol), N-(tert- butoxycarbonyl)-β-alanine (25 mg, 0.13 mmol), EDCI (38 mg, 0.20 mmol), and DMAP (2 mg, 0.02 mmol) in dichloromethane (2 mL) was stirred for 16 hours, diluted with ethyl acetate (50 mL), washed sequentially with IM HCl (5 mL), water (5 mL), and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 2-8 % methanol/dichloromethane to provide the desired product. MS (ESI(-)) m/e 748 (M-H) " . Example 49B N-(4'-((((4-((l-adamantylmethyl amino)-3-nitrophenyl sulfonyl)amino carbonylV4- fluoro(l , 1 '-biphenyι)-2-yl)-3-aminopropanamide A room temperature solution of Example 49 A (19 mg, 0.03 mmol) in dichloromethane (1 mL) was treated with 4M HCl in dioxane, stirred for 4 hours, and concentrated to provide the desired product. MS (ESI(+)) m/e 650 (M+H) + ; H NMR (400 MHz, DMSO-d 6 ) δ 9.12 (br s, IH), 8.65 (d, IH), 8.56 (t, IH), 7.95 (dd, IH), 7.94 (m, 3H), 7.65 (br s, 3H), 7.50-7.35 (m, 4H), 7.15 (dt, IH), 3.18 (d, 2H), 2.75 (s, 6H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 50 4-(( 1 -adamantylmethyl amino -3-nitro-N-((2',4',5'-trimethyl( 1 , 1 '-biphenyl)-4- yP carbonypbenzenesulfonamide Example 50A 2',4',5'-trimethyl(l.r-biphenyl)-4-carboxyHc acid The desired product was prepared by substituting l-bromo-2,4,5-trimethylbenzene for 2-bromo-5-chlorothiophene in Example 29A. MS (APCI(-)) m/e 239 (M-H) " . Example 50B 4-((l-adamantylmethyl)amino)-3-nitro-N-((2'.4',5'-trimethyl(l '-biphenyl)-4- yl)carbonyl)benzenesulfonamide The desired product was prepared by substituting Example 50A for Example 29A in Example 29B. MS (APCI(+) m/e 588 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.57 (t, IH), 7.95 (dd, IH), 7.91 (d, 2H), 7.41 (d, 2H), 7.36 (d, IH), 7.06 (s, IH), 6.97 (s, IH), 3.18 (d, 2H), 2.21 (s, 3H), 2.20 (s, 3H), 2.13 (s, 3H), 1.97 (s, 3H), 1.58 (m, 12H). Example 1 4-((l-adamantylrnethyl)amino)-N-(4-mesitylbenzoyl)-3-nitrobenzenesulfonamide Example 51 A 2',4',6'-trimethyl( 1 , 1 '-biphenyl)-4-carboxyHc acid The desired product was prepared by substituting 2-bromo-l,3,5-trimethylbenzene for 2-bromo-5-chlorothiophene in Example 29A. MS (APCI(-)) m/e 239 (M-H) " . Example 5 IB 4-((l-adamantylmethyl)amino)-N-(4-mesitylbenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 51 A for Example 29A in Example 29B. MS (APCI(+)) m/e 588 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.57 (t, IH), 7.95 (m, 3H), 7.36 (d, IH), 7.23 (d, 2H), 6.93 (s, 2H), 3.18 (d, 2H), 2.26 (s, 3H), 1.97 (s, 3H), 1.89 (s, 6H), 1.58 (m, 12H). Example 52 4-(( 1 -adamantylmethyl)amino)-N-(4-( 1 ,3-benzodioxol-5-vι)benzoyI)-3- nitrobenzenesulfonamide Example 52A 4-(l ,3-benzodioxol-5-yl)benzoic acid The desired product was prepared by substituting 5-bromo-l,3-benzodioxole for 2- bromo-5-chlorothiophene in Example 29A. Example 52B 4-((l-adamantylmethyl)amino)-N-(4-(l,3-benzodioxol-5-yl)benzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 52A for Example 29A in Example 29B. MS (APCI(+)) m/e 590 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 8.66 (d, IH), 8.57 (t, IH), 7.95 (dd, IH), 7.91 (d, 2H), 7.73 (d, 2H), 7.36 (d, IH), 7.33 (d, IH), 7.24 (dd, IH), 7.01 (d, IH), 6.08 (s, 2H), 3.18 (d, 2H), 1.97 (s, 3H), 1.58 (m, 12H). Example 53 4-((l-adamantylmethyl)amino)-N-(4-(lH-indol-6-yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 4A and Example 28 A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 583 (M-H) " ; 1H NMR (300 MHz, DMSO-dβ) δ 8.65 (m, IH), 8.55 ( , IH), 7.97 (m, 2H), 7.77 (m, 2H), 7.67 (m, 2H), 7.38 (m, 3H), 6.48 (m, IH), 3.18 (m, 2H), 1.98 (m, 3H), 1.62 (m, 12H). Example 54 4-((l-adam-mtylmethyl)amino -N- 4-(2-methyl-1.3-benzoxazol-5-yl)benzoyl)-3- nitrobenzenesulfonamide Example 54A methyl 4-(2-methyl- 1 ,3-benzoxazol-5-yl benzoate A room temperature solution of 5-chloro-2-methyl-l,3-benzoxazole (110 mg, 0.71 mmol), CsF (325 mg, 2.14 mmol), Pd(OAc) 2 (6.0 mg, 0.028 mmol), 2- dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl (14 mg, 0.036 mmol) and 4- (methoxycarbonyl)phenylboronic acid (180 mg, 1.0 mmol) in dioxane (4 mL) was stirred for 18 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with 15% ethyl acetate/hexanes to provide the desired product. H NMR (300 MHz, DMSO-d 6 ) δ 8.06 (d, 2H), 8.03 (d, IH), 7.90 (d, 2H), 7.78 (d, 2H), 7.71 (dd, IH), 7.29 (d, 2H), 3.90 (s, 3H), 2.65 (s, 3H). Example 54B 4-(2-methyl- 1 ,3-benzoxazol-5-yl benzoic acid A room temperature solution of Example 54A (80 mg, 3.0 mmol) and LiOH (630 mg, 15.0 mmol) in a mixture of THF (15 mL), water (4 mL), and methanol (4 mL) was stirred for 1 hour, poured into IM HCl, and extracted with ethyl acetate. The combined extracts were washed with brine, dried (Na 2 SO 4 ), filtered, and concentrated to provide the desired product of sufficient purity for subsequent use. Example 54C 4-((l-adamantylm.ethyl)amino -N-(4-(2-methyl-l,3-benzoxazol-5-yl)benzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 54B and Example 28A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 599 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.52 (d, IH), 7.99-7.92 (m, 3H), 7.90 (dd, IH), 7.64-7.52 (m, 4H), 7.17(d, IH), 3.12 (d, 2H), 2.63 (s, 3H), 1.97 (m, 2H), 1.71-1.54 (m, 13H). Example 55 4-((l-adamantylmethyl)amino)-N-(4-(2-methyl-l,3-benzothiazol-5-yl benzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 17A and Example 28A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 615 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.68 (d, IH), 8.59 (t, IH), 8.26 (s, IH), 8.14 (d, IH), 7.98 (d, 2H), 7.95 (dd, IH), 7.90 (d, 2H), 7.77 (dd, IH), 7.37 (d, IH), 3.19 (d, 2H), 2.82 (s, 3H), 1.98 (br s, 3H), 1.73-1.55 (m, 12H). Example 56 4-((l-adamantylmethyl)amino)-N-(4-(2-ethyl-l,3-benzothiazol-5-yl)benzoyl)-3- nitrobenzenesulfonamide Example 56A 5-bromo-2-ethyl-l,3-benzothiazole A 0 °C solution of diisopropylamine (340 μL, 2.41 mmol) in THF (3 mL) was treated with 2.5M n-butyllithium in hexanes (0.88 mL), stirred for 20 minutes, added to a -78 °C solution of 5-bromo-2-methyl- 1 ,3-benzothiazole (250 mg, 1.10 mmol) in THF (3 mL), stirred for 30 minutes, treated with iodomethane (340 μL, 5.50 mmol), and stirred for 1 hour. The mixture was diluted with ethyl acetate (50 mL), washed sequentially with IM HCl (5 mL), water (5 mL), and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 30% hexanes/dichloromethane to provide the desired product. MS (DCI) m/e 242 (M+H) : Example 56B 4-(2-ethyl-l ,3-benzothiazol-5-yl) benzoic acid The desired product was prepared by substituting Example 56A for 6-bromoindole in Example 4A. MS (ESI(+)) m/e 284 (M+H) + . Example 56C 4-((l-adamantylmethyl)amino -N-(4-(2-ethyl-l,3-benzothiazol-5-yl)benzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 56 B and Example 28A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 629(M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.68 (d, IH), 8.57 (t, IH), 8. 28 (s, IH), 8.16 (d, IH), 7.98 (d, 2H), 7.95 (dd, IH), 7.90 (d, 2H), 7.77 (dd, IH), 7.36 (d, IH), 3.19 (d, 2H), 3.15 (q, 2H), 1.98 (br s, 3H), 1.73-1.55 (m, 12H), 1.40 (t, 3H). Example 57 N-(4-(3,4,4a,5,6.7,8.8a-oct-mydro-l-naphthalenyl)benzoyl)-4-((l-adamantylmethyl amino)- 3-nitrobenzenesulfonamide and 4-(( 1 -adamantylmethyl)amino)-N-(4-(2.3 ,4,4a,5,6.7.8-octahydro- 1 -naphthalenyl)benzoyl)-3 - nitrobenzenesulfonamide Example 57A methyl 4-(3,4,4a,5,6,7.8.8a-octahydro-l-naphthalenyl)benzoate and methyl 4-(2,3 ,4.4a,5,6.7, 8-octahydro- 1 -naphthalenyl)benzoate The desired product was prepared by substituting 1-decalone for 4-tert- butylcyclohexanone in Examples 5A and 5B. MS (DCI) m/e 271 (M+H) . Example 57B N-(4-(3,4,4a,5,6,7,8,8a-octahydro-l-naphthalenyl benzoyl)-4-((l-adamantylmethyl amino)- 3-nitrobenzenesulfonamide and 4-((l-adamantylmethyl)amino)-N-(4-(2.3,4,4a,5,6,7,8-octahydro-l-naphthalenyl)benzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 57A and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(+)) m/e 604 (M+H) ; 1H NMR (400 MHz, DMSO-de) δ 8.64 (d, IH), 8.59(t, IH), 7.92 (dd, IH), 7.80 (d, 2H), 7.36 (d, IH), 7.28 (d, 2H), 5.80(m, IH), 3.18 (d, 2H), 2.30-2.20 (m, 3H), 1.96 (m, 3H), 1.70-1.55 (m, 17H), 1.40-1.20 (m, 6H). Example 58 N-(4-(l,4,4a,5,6,7,8,8a-octahycko-2-naphthalenyl)benzoyl)-4-((l-adamantylmethyl)amino)- 3 -nitrobenzenesulfonamide and N- 4-(3,4,4a,5,6,7,8,8a-octahydro-2-naphthalenyl)benzoyl)-4-((l-adamantylmethyl)amino)- 3 -nitrobenzenesulfonamide Example 58A methyl 4-(l,4,4a,5,6,7.8.8a-octahydro-2-naphthalenyl)benzoate and methyl 4-(3,4.4a.5.6,7.8.8a-octahydro-2-naphthalenyl)benzoate The desired product was prepared by substituting 2-decalone for 4-tert- butylcyclohexanone in Examples 5A and 5B. MS (DCI) m/e 271 (M+H) . Example 58B N-(4-(l,4.4a.5.6.7.8,8a-octahydro-2-naphthalenyl)benzoyl -4-((l-adamantylmethyl)amino)- 3 -nitrobenzenesulfonamide and N-(4-(3,4,4a.5.6.7.8,8a-octahydro-2-naphthalenyl)benzoyl)-4-((l-adamantylmethyl)amino)- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 58A and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(+)) m/e 604 (M+H) ; ! H NMR (400 MHz, DMSO-de) δ 8.52 (d, IH), 8.40(t, IH), 7.88 (dd, IH), 7.80 (d, 2H), 7.36 (d, 2H), 7.28 (d, 2H), 6.13 and 6.07 (m, IH total), 3.12 (d, 2H), 2.38 (m, 3H), 1.96 (m, 3H), 1.70-1.40 (m, 23H). Example 59 4-((l-adamantylmethyl)amino)-N-(4-decahydro-l-naphthalenylbenzoyl)-3- nitrobenzenesulfonamide Example 59A methyl 4-decahydro-l-naphthalenylbenzoate The desired product was prepared by substituting Example 57A for Example 5B in Example 5C. MS (DCI) m/e 273 (M+H) + . Example 59B 4-((l-adamantylmethyl)amino)-N-(4-decahydro-l-naphthalenylbenzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 59A and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(+)) m/e 606 (M+H) ; 1H NMR (400 MHz, DMSO-de) δ 8.64 (d, IH), 8.59 (t, IH), 7.92 (dd, IH), 7.78 (d, 2H), 7.36 (d, IH), 7.28 (d, 2H), 3.18 (d, 2H), 2.30 (m, 1H),1.96 (m, 3H), 1.75-1.10 (m, 28H). Example 60 4-((l-adamantylmethyl)amino)-N-(4-decahydro-2-naphthalenylbenzoyl)-3- nitrobenzenesulfonamide Example 60A ' methyl 4-decahydro-2-naphthalenylbenzoate The desired product was prepared by substituting Example 58A for Example 5B in Example 5C. MS (DCI) m/e 273 (M+H) + . Example 60B 4-((l-adamantylmethyl)amino)-N-(4-decahydro-2-naphthalenylbenzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 60A and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI) m/e 606 (M+H) ; H NMR (400 MHz, DMSO-d 6 ) δ 8.62 (d, IH), 8.55 (t, IH), 7. 92 (dd, IH), 7.78 (d, 2H), 7.36 (m, 4H), 3.18 (d, 2H), 2.55 (m, IH), 1.96 (m, 3H), 1.75-1.20 (m, 28H). Example 61 4-(( 1 -adamantylmethyl amino)-3 -nitro-N-(4-(3 ,5,5,8 , 8-pentamethyldecahy dro-2- naphthalenyl)benzoyl)benzenesulfonamide Example 61A methyl 4-(3, 5,5, 8, 8-pentamethyldecahydro-2-naphthalenyl)benzoate The desired product was prepared by substituting 3,5,5,8,8-pentamethyloctahydro- 2(lH)-naphthalenone for 4-tert-butylcyclohexanone in Examples 5A-5C. MS (DCI) m/e 343 (M+H) + . Example 6 IB 4-((l-adamantylmethyl amino)-3-nitro-N-(4-(3, 5,5,8, 8-pentamethyldecahydro-2- naphthalenyl)benzoyl)benzenesulfonamide The desired product was prepared by substituting Example 61 A and Example 28 A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(+)) m/e 676 (M+H) ; 1H NMR (400 MHz, DMSO-de) δ 8.62 (d, IH), 8.55 (t, IH), 7. 92 (dd, IH), 7.78 (d, 2H), 7.36 (m, 4H), 3.18 (d, 2H), 2.49 (m, IH), 1.96 (m, 3H), 1.80-1.20 (m, 22H), 0.90 (m, 6H), 0.87 (s, 3H), 0.78 (s, 3H), 0.71(s, 3H). Example 62 4-(( 1 -adamantylmethyl)amino)-N-(4-( 1 -cyclohexen- 1 -vDbenzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 9A and Example 28 A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 548 (M-H) " ; H NMR (400 MHz, CD 3 OD) δ 8.86 (d, IH), 8.03 (dd, IH), 7.76 (dt, 2H), 7.47 (dt, 2H), 7.21 (d, IH), 6.27 (m, IH), 3.14 (t, 2H), 2.42 (m, 2H), 2.24 (m, 2H), 2.01 (m, 3H), 1.85-1.65 (m, 16H). Example 63 4-(( 1 -adamantylmethyl)amino)-N-(4-( 1 -cyclohepten- 1 -yI)benzovD-3~ nitrobenzenesulfonamide Example 63A methyl 4-(l -cyclohepten- 1 -yPbenzoate The desired product was prepared by substituting cycloheptanone for 4-tert- butylcyclohexanone in Examples 5A and 5B. MS (DCI) m/e 231 (M+H) . Example 63 B 4-(( 1 -adamantylmethyl)amino)-N-(4-( 1 -cyclohepten- 1 -vDbenzovD-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 63A and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(+)) m/e 564 (M+H) ; 1H NMR (400 MHz, DMSO-de) δ 8.63 (d, IH), 8.45(t, IH), 7.92 (dd, IH), 7.80 (d, 2H), 7.40 (d, 2H), 7.35 (d, IH), 6.21 (t, IH), 3.18 (d, 2H), 2.55 (m, 2H), 2.29 (m, 2H), 1.98 (m, 3H), 1.80-1.20 (m, 18H). , Example 64 4-((l-adamantvhnethyl amino -N-(4-cycloheptylbenzoyl -3-nitrobenzenesulfonamide Example 64A methyl 4-cycloheptylbenzoate The desired product was prepared by substituting Example 63A for Example 5B in Example 5C. MS (DCI) m/e 233 (M+H) + . Example 64B 4-((l-adamantylmethyl)amino)-N-(4-cycloheptylbenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 64A and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(+)) m/e 566 (M+H) ; 1H NMR (400 MHz, DMSO-de) δ 8.63 (d, IH), 8.55 (t, IH), 7. 92 (dd, IH), 7.79 (d, 2H), 7.35 (d, IH), 7.30 (d, 2H), 3.18 (d, 2H), 2.73 (m, IH), 1.98 (m, 3H), 1.80-1.50 (m, 24H). Example 65 4-((l-adamantylmethyl)amino)-N-(4-(l-cycloocten-l-yl)benzoyl)-3-nitrobenzenesulfonamide Example 65A methyl 4-( 1 -cycloocten- 1 -yPbenzoate The desired product was prepared by substituting cyclooctanone for 4-tert- butylcyclohexanone in Examples 5A and 5B. MS (DCI) m/e 245 (M+H) . Example 65B 4-((l-adamantyhnethyl)amino)-N-(4-(l-cycloocten-l-yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 65A and Example 28A for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(+)) m/e 578 (M+H) ; 1H NMR (400 MHz, DMSO-de) δ 8.63 (d, IH), 8.55( t, IH), 7. 92 (dd, IH), 7.80 (d, 2H), 7.50 (d, 2H), 7.35 (d, IH), 6.21 (t, IH), 3.18 (d, 2H), 2.60 (m, 2H), 2.29 (m, 2H), 1.98 (m, 3H), 1.80-1.20 (m, 20H). Example 66 4-((l-adamantylmethyl)amino -N-(4-cyclooctylbenzoyl)-3-nitrobenzenesulfonamide Example 66A methyl 4-cyclooctylbenzoate The desired product was prepared by substituting Example 65A for Example 5B in Example 5C. MS (DCI) m/e 247 (M+H) + . Example 66B 4-((l-adamantylmethyl)amino -N-(4-cyclooctylbenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 66A and Example28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(+)) m/e 580 (M+H) ; 1H NMR (400 MHz, DMSO-de) δ 8.63 (d, IH), 8.57 (t, IH), 7. 92 (dd, IH), 7.78 (d, 2H), 7.35 (d, IH), 7.31 (d, 2H), 3.18 (d, 2H), 2.71 (m, IH), 1.98 (m, 3H), 1.80-1.50 (m, 26H). Example 67 4-((l-adamantylmethyl)amino)-3-nitro-N-(4-(5-nitro-2- pyridinyl)benzoyl)benzenesulfonamide Example 67A 4-(5-nitro-2-pyridinyl)benzoic acid The desired product was prepared by substituting 2-bromo-5-nitropyridine for 2- bromo-5-chlorothiophene in Example 29 A. MS (APCI(-)) m/e 243 (M-H) " . Example 67B 4-((l-adamantylmethyl)amino)-3-nitro-N-(4-(5-nitro-2- pyridinyl)benzoyl)benzenesulfonamide The desired product was prepared by substituting Example 67A for Example 29A in Example 29B. MS (APCI(+)) m/e 592 (M+H) + ; H NMR (500 MHz, DMSO-de) δ 8.68 (m, 2H), 8.57 (t, IH), 8.35 (d, IH), 8.30 (d, 2H), 8.04 (d, 2H), 7.96 (m, IH), 7.36 (m, 2H), 3.18 (d, 2H), 1.97 (s, 3H), 1.58 (m, 12H). Example 68 4-((l-adamantyhnethyl)(2-(phenylsulfanyl)ethyl)amino -N-(4-(l-cyclohexen-l-yl)benzoyl)- 3 -nitrobenzenesulfonamide Example 68A N-( 1 -adamantylmethyl)-2-(phenylsulfanyl)acetamide A room temperature solution of (phenylsulfanyl)acetic acid (1.68 g, 10.0 mmol) in dichloromethane (10 mL) was treated with 2M oxalyl chloride in dichloromethane (8 mL, 16.0 mmol) and DMF (1 drop), stirred for 2 hours, concentrated, dissolved in dichloromethane (10 mL), treated with 1-adamantylmethylamine (1.65 g, 10.0 mmol) and N,N-dusopiOpylethylamine (2.1 mL, 12.0 mmol), and stirred for 1 hour. The mixture was filtered through a pad of sihca gel (20 g) and concentrated to provide the desired product of sufficient purity for subsequent use. Example 68B N-( 1 -adamantylmethyl)-2-(phenylsulfanyl) ethanamine A solution of Example 68A in THF (5 mL)was treated with IM LAH in THF (20 mL, 20.0 mmol), heated to reflux, stirred for 24 hours, cooled to room temperature, treated sequentially with water (0. 8mL), 15% NaOH (0.8 mL), and water (2.4 mL), stirred for 30 minutes, filtered through diatomaceous earth (CeHte ), and concentrated. The concentrate was purified by flash column chromatography on silica gel with 20-100% ethyl acetate/hexanes to provide the desired product. Example 68C 4-(( 1 -adamantylmtethyl (2-(phenylsulfanyl)ethyl amino)-N-(4-( 1 -cyclohexen- 1 -yl)benzoyl)- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 9B and Example 68B for Example 7C and Example ID, respectively, in Example 7D. MS (ESI(-)) m/e 684 (M-H) " ; H NMR (400 MHz, DMSO-de) δ 8.69 and 8.60 (2br s, IH total), 8.92 and 8.38 (2d, IH), 8.16 and 8.06 (2dd, IH), 7.60 (t, 2H), 7.46 (dd, 2H), 7.40 (d, IH), 7.35-7.10 (m, 5H), 6.28 (m, IH), 3.40-2.90 (m, 6H), 2.40 (m, 2H), 2.23 (m, 2H), 2.05-1.20 (m, 19H). Example 69 4-(benzhydrylamino)-N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting benzhydrylamine for 2,2- dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 582 (M+H) + ; H NMR (500 MHz, DMSO-de) δ 12.55 (br s, IH), 8.88 (d, IH), 8.71 (d, IH), 7.96 (dd, IH), 7.94 (d, 2H), 7.80-7.76 (m, 4H), 7.48-7.46 (m, 4H), 7.41-7.37 (m, 4H), 7.34-7.29 (m, 4H), 7.05 (d, IH), 6.19 (d, lH). Example 70 4-(( 1 ,2-diphenylethyl)amino -N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3 - nitrobenzenesulfonamide The desired product was prepared by substituting 1,2-diphenylethanamine for 2,2- dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 613 (M+NH 4 ) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.81 (d, IH), 8.63 (d, IH), 7.93 (d, 2H), 7.86 (dd, IH), 7.81-7.76 (m, 4H), 7.48 (d, 2H), 7.37-7.26 ( , 9H), 7.22-7.18 (m, IH), 7.03 (d, IH), 5.19 (ddd, IH), 3.30 (dd, IH), 1.61 (dd, IH). Example 71 4-((l-cyclohexyl-2-(phenylsulfanyl)ethyl)amino)-N-((4'-fluoro(l,r-biphenyl)-4-yl)carbonyl)- 3 -nitrobenzenesulfonamide Example 71 A l-cyclohexyl-2-(phenylsulfanyl)ethanol A room temperature solution of vinylcyclohexane (1.71 g, 15.5 mmol) in dichloromethane (20 mL) was treated with 70% mCPBA (4.90 g, 19.9 mmol), stirred for 3 hours, dUuted with diethyl ether (100 mL), washed with saturated NaHCO 3 and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was dissolved in 1,2-dichloroethane (20 mL), treated with thiophenol (1.8 g, 16.3 mmol), heated to 80 °C, stirred for 5 hours, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 20% ethyl acetate/hexanes to provide the desired product. MS (DCJJNH 3 ) m e 254 (M+ NH4). Example 7 IB 1 -cvclohexyl-2-(phenylsulfanvf) ethanamine The desired product was prepared by substituting Example 71 A for Example 7A in Examples 7B and 7C. Example 71 C 4-((l-cyclohexyl-2-(phenylsulfanyl)ethyl)amino)-N-((4'-fluoro(l,r-biphenyl)-4-yl)carbonyl)- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 7 IB for Example 7C in Example 7D. MS (ESI(-)) m/e 632 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.55 (d, IH), 8.20 (t, IH), 8.02-7.72 (m, 4H), 7.43-7.10 (m, HH), 3.20-3.15 (m, 3 H), 1.60-1.00 (m, HH). Example 72 N-(4-(l-cyclohexen-l-yl)benzoyl)-4-((l-cyclohexyl-2-(phenylsulfanyl)ethyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 7 IB and Example 9B for Example 7C and Example ID in Example 7. MS (ESI(-)) m/e 618 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.70 (m, IH), 8.53 (d, IH), 7.73 (m, 3H), 7.49 (m, 2H), 7.28 (m, 2H), 7.20-7.06 (m, 4H), 6.32 (m, IH), 4.05-3.48 (m, 3H), 2.37 (m, 2H), 2.19 (m, 2H), 2.00-1.10 (m, 15H). Example 73 4-(Y2EV2-f 3 ,4-dihvdro- 1 (2H -naphthalenylidene hvdrazino -N-((4'-fluoro( 1.1 '-biphenvD-4- yl)carbonyl)-3-nitroberιzenesulfonamide Example 73A tert-butyl 2-(4-(arninosulfonyl)-2-nitrophenyl)hydrazinecarboxylate A solution of Example ID (212 mg, 0.49 mmol) and tert-butylcarbazate (976 mg, 2.3 mmol) in ethanol (5 mL) was heated to reflux, stirred for 16 hours, dUuted with ethyl acetate (50 mL), washed with water and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 1:0.5:98.5/methanol: acetic acid: dichloromethane, then 2:0.5:97.5/methanol:acetic acid: dichloromethane to provide the desired product. MS (ESI(-)) m/e 331 (M-H) " . Example 73B 4-((2E)-2-(3,4-dihydro-l(2H)-naphthalenylidene)hydrazino)-3-nitrobenzenesulfonamide A room temperature solution of Example 73A (145 mg,0.44 mmol) in 1:1 TFA/dichloromethane (10 mL) was stirred for 4 hours and concentrated. The concentrate was dissolved in ethanol (2 mL), treated with 3, 4-dihydro- 1(2H)- naphthalenone (8.2 mg, 0.06 mmol) and pyridinium p-toluenesulfonate (2 mg, 0.008 mmol), heated to reflux, stirred for 2 hours, cooled to room temperature, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 4% methanoPdichloromethane to provide the desired product. MS (ESI(-)) m/e 359 (M-H) " . Example 73 C 4-((2E)-2-(3.4-dihvdro- 1 (2H -naphthalenylidene hvdrazino -N-((4'-fluoroπ .1 '-biρhenyl -4- yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 73B for Example IC in Example ID. MS (ESI(-)) m/e 557 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.10 (s, IH), 8.70 (t, IH), 8.19 (dd, IH), 8.14 (s, 2H), 7.96 (dt, 2H), 7.80-7.70 (m, 4H), 7.36-7.23 (m, 5H), 2.80 (m, 4H), 1.95 (m, 2H). Example 74 4-((3-cyclohexylpropyl)amino -N-((4'-fluoro(U'-biphenyl -4-yl carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 3 -cyclohexyl- 1-propanamine and Example ID for cyclohexylamine and Example IC, respectively, in Example 3 A. MS (ESI(+)) m/e 540 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.59 (d, IH), 8.47 (t, IH), 7.95 (m, 3H), 7.75 (dd, 2H), 7.68 (d, 2H), 7.30 (dd, 2H), 7.13 (d, IH), 3.39 (m, 2H), 1.71- 1.55 (m, 6H), 1.29-1.12 (m, 7H), 0.93-0.79 (m, 2H). Example 75 N-((4'-fluoro(l,r-biphenyl -4-yl carbonyl)-3-nitro-4-(2- (phenylsulfanyl)ethoxy benzenesulfonamide Example 75A N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)c-ιrbonyl)-4-(2-hydroxyethoxy)-3-nitroberιzenesulfonamide A room temperature solution of NaH (1.52 g, 38.0 mmol) in DMF (100 mL) was treated with ethylene glycol (4.23 mL, 76.0 mmol) over 10 minutes, then treated sequentially with 15-crown-5 (7.54 mL, 38.0 mmol) and Example ID (3.30 g, 7.6 mmol), and stirred for 30 minutes, quenched with IM HCl, and extracted with ethyl acetate. The combined extracts were washed with water and brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with ethyl acetate to provide the desired product. MS (ESI(+)) m/e 461 (M+H) + . Example 75B 5 N-((4'-fluorori.r-biphenyl -4-vDcarbonvD-3-nitro-4-(2- (phenylsulfanyl)ethoxy)benzenesulfonamide The desired product was prepared by substituting Example 75A for Example 27A in ' Example 27B. MS (ESI(-)) m/e 551 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.29 (d, IH), 8.04 (dd, IH), 7.96 (d, 2H), 7.73 (dd, 2H), 7.61 (d, 2H), 7.40 (d, 2H), 7.39 (s, IH), 7.32 (d, 2H), 7.28 (d, 2H), 7.21 (dd, IH), 4.39 (t, 2H), 3.40 (t, 2H). Example 76 N-(4-( 1 -cyclohexen- 1 -yl)benzoyl)-3 -nitro-4-((2- (phenylsulfonyl) ethyl) amino)benzenesulfonamide 5 Example 76A 2-(phenylsulfonyl)ethanamine A mixture of ((2-chloroethyl)sulfonyl)benzene (1.02 g, 5.0 mmol), potassium phthalimide (1.02 g, 5.5 mmol), 18-crown-6 (50 mg), and tetrabutylammonium iodide (50 mg) in dioxane was heated to reflux, stirred for 24 hours, cooled to room temperature, dUuted with ethyl acetate (100 mL), washed with water and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was dissolved in ethanol (10 mL), treated with hydrazine hydrate (1 mL), heated to reflux, stirred for 2 hours, cooled to room temperature, filtered (S) through diatomaceous earth (Celite ), and rinsed with ethyl acetate. The filtrate was treated with ethyl acetate, washed with water and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was dissolved in diethyl ether (5 mL), treated with IM HCl in diethyl ether (10 mL), and filtered. The sohd was washed with diethyl ether, suspended in ethyl acetate (80 mL), washed with 2M Na 2 CO 3 and brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. Example 76B N-(4-( 1 -cyclohexen- 1 -yl)benzoyl)-3-nitro-4-((2- (phenylsulfonyl)ethyl amino)benzenesulfonamide The desired product was prepared by substituting Example 76A and Example 9B for Example 7C and Example ID, respectively, in Example 7D. MS (ESI(-)) m/e 568 (M-H) " ; ! H NMR (400 MHz, DMSO-de) δ 8.59 (d, IH), 8.57 (t, IH), 7.93 (dd, IH), 7.84 (m, 4H), 7.67 (m, IH), 7.56 (d, 2H), 7.51 (d, 2H), 7.14 (d, IH), 6.33 (m, IH), 3.79 (s, 2H), 2.38 (m, 2H), 2.19 (m, 2H), 1.72 (m, 2H), 1.59 (m, 2H). Example 77 N-(4-(4,4-dimethylcyclohexyl)benzoyl)-3-nitro-4-((2- (phenylsulfanyl)ethyl)amino)benzenesulfonamide Example 77A methyl 4-(4.4-dimethylcyclohexyl)benzoate The desired product was prepared by substituting 4,4-dimethylcyclohexanone for 4- tert-butylcyclohexanone in Examples 5A-5C. MS (DCI) m/e 247 (M+H) + . Example 77B 3-nitro-4-((2-(phenylsulfanyl)ethyl)amino)benzenesulfonamide A solution Example IC (2.36 g, 10.0 mmol), 2-(phenylsulfanyl)ethanamine (1.68 g, 11.0 mmol), and triethylamine in dioxane (5 mL) was heated to 80 °C, stirred for 16 hours, dUuted with ethyl acetate (100 mL), washed sequentially with 3M HCl, water, and brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (DCI) m/e 354 (M+H) + . Example 77C N-(4-(4,4-dimethylcyclohexyl benzoyl)-3-nitro-4-((2- (phenylsulfanyl)ethyl)amino benzenesulfonamide The procedure used in Example 5 was used here to convert the products from Examples 78A and 78B to the title compound. MS (ESI(-)) m/e 566 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.80 (t, IH), 8.61 (d, IH), 7.91 (dd, IH), 7.79 (d, 2H), 7.48 (m, 4H), 7.40-7.15 (m, 4H), 3.66 (q, 2H), 3.29 (t, 2H), 2.49 (m, 1H)1.65-1.20 (m, 8H), 0.96 (s, 3H), 0.93 (s, 3H). Example 78 N-((4'-fluoro(l,r-biphenyl)-4-yl)carbonyl)-4-((2-((2-methylphenyl)sulfanyl)ethyl amino)-3- nitrobenzenesulfonamide Example 78A N-((4'-fluoro(l, -biphenyl -4-yl)carbonyl)-4-((2-hydroxyethyl)amino)-3- mtrobenzenesulfonamide The desired product was prepared by substituting 2-aminoethanol and Example ID for cyclohexylamine and Example IC, respectively, in Example 3 A. MS (ESI(-)) m/e 458 (M-H) " . Example 78B N-((4'-fluoro(l '-biphenyl)-4-yl)cai-bonyl)-4-((2-((2-methylphenyl)sulfanyl)ethyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 2-methylbenzenethiol and Example 78A for Example 27A and thiophenol, respectively, in Example 27B. MS (ESI(-)) m/e 564 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.54 (t, IH), 8.52 (d, IH), 7.95 (d, 2H), 7.87 (dd, IH), 7.74 (dd, 2H), 7.59 (d, 2H), 7.45-7.37 (m, IH), 7.28 (t, 2H), 7.23-7.08 (m, 3H), 6.98 (d, IH), 3.59 (dt, 2H), 3.25 (t, 2H), 2.28 (s, 3H). Example 79 4-((2-((2-chlorophenyl)sulfanyl)ethyl ' )amino)-N-((4'-fluoro( 1 , 1 '-biphenylV4-yl carbonyl)-3- mtrobenzenesulfonamide The desired product was prepared by substituting 2-chlorobenzenethiol and Example 78A for thiophenol and Example 27A, respectively, in Example 27B. MS (ESI(-)) m/e 584 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.60 (t, IH), 8.55 (d, IH), 7.98-7.88 (m, 3H), 7.75 (dd, 2H), 7.63 (d, 2H), 7.54 (dd, IH), 7.45 (dd, IH), 7.34-7.25 (m, 3H), 7.19 (td, IH), 7.12 (d, IH), 3.67 (dt, 2H), 3.28 (t, 2H). Example 80 N-((4'-fluoro( 1 , 1 '-biphenyl -4-yl carbonyl -3-nitro-4-((2- (2- (trifluoromethyl phenyl)sulfanyl)ethyl)amino benzenesulfonamide The desired product was prepared by substituting 2-(trifluoromethyl)benzenethiol and Example 78A for thiophenol and Example 27A, respectively, in Example 27B. MS (ESI(-)) m/e 618 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.52 (d, IH), 8.50 (t, IH), 7.95 (d, 2H), 7.90 (dd, IH), 7.78-7.67 (m, 4H), 7.61 (d, 3H), 7.38 (t, IH), 7.28 (t, 2H), 7.05 (d, IH), 3.64 (dt, 2H), 3.38 (t, 2H). Example 81 N-((4'-fluoro(l.r-biphenyl)-4-yl)carbonyl -4-((2-((3-methylphenyl)sulfanyl)ethyl amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 3-methylbenzenethiol and Example 78A for thiophenol and Example 27A, respectively, in Example 27B. MS (ESI(-)) m/e 564 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.56 (t, IH), 8.54 (d, IH), 7.95 (d, 2H), 7.89 (dd, IH), 7.75 (dd, 2H), 7.64 (d, 2H), 7.28 (t, 2H), 7.22-7.15 (m, 3H), 7.06-6.96 (m, 2H), 3.62 (dt, 2H), 3.25 (t, 2H), 2.25 (s, 3H). Example 82 N-((4'-fluoro( 1 , 1 '-biphenyl -4-yl)carbonyl)-4-((2-((4-methylphenyl)sulfanyl)ethyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 4-methylbenzenethiol and Example 78A for thiophenol and Example 27A in Example 27B. MS (ESI(-)) m/e 564 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (t, IH), 8.61 (d, IH), 7.96 (d, 2H), 7.92 (dd, IH), 7.80 (m, 4H), 7.37-7.24 (m, 4H), 7.20 (d, IH), 7.07 (d, 2H), 3.64 (dt, 2H), 3.23 (t, 2H), 2.24 (s, 3H). Example 83 N-(V4'-fluoro( 1.1 '-biphenyl)-4-yl carbonvn-3-nitro-4-((2-((4- nitrophenyl)sulfanyl)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting 4-nitrobenzenethiol and Example 78A for thiophenol and Example 27A, respectively, in Example 27B. MS (ESI(-)) m/e 595 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.56 (t, IH), 8.51 (d, IH), 8.11 (d, 2H), 7.97-7.89 (m, 3H), 7.74 (dd, 2H), 7.64-7.56 (m, 4H), 7.28 (t, 2H), 7.14 (d, IH), 3.72 (dt, 2H), 3.45 (t, 2H). Example 84 4-((2-((2,4-difluorophenyl)sulf-myl)ethyl amino)-N-((4'-fluoro(l,r-biphenyl)-4-yl)carbonyl - 3 -nitrobenzenesulfonamide The desired product was prepared by substituting 2,4-difluorobenzenethiol and Example 78 A for thiophenol and Example 27 A, respectively, in Example 27B. MS (ESI(-)) m/e 586 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.51 (d, IH), 8.47 (t, IH), 7.95 (d, 2H), 7.89 (dd, IH), 7.74 (dd, 2H), 7.62-7.53 (m, 3H), 7.34-7.23 (m, 3H), 7.11-7.03 (m, IH), 7.00 (d, IH), 3.57 (dt, 2H), 3.21 (t, 2H). Example 85 4-((2-((2.4-dimethylphenyl sulfanyl ethyl amino -N-((4'-fluoroπ.r-biphenyl -4- yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting 2,4-dimethylbenzenethiol and Example 78A for thiophenol and Example 27A, respectively, in Example 27B. MS (ESI(-)) m/e 578 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.52 (t, IH), 8.50 (d, IH), 7.95 (d, 2H), 7.87 (dd, IH), 7.73 (dd, 2H), 7.60 (d, 2H), 7.34-7.24 (m, 3H), 7.03-6.92 (m, 3H), 3.54 (dt, 2H), 3.18 (t, 2H), 2.27 (s, 3H), 2.22 (s, 3H). Example 86 N-(4-(2-methyl- 1 ,3-benzoxazol-5-yl)benzoyl -3-nitro-4-((2- (phenylsulfanyl)ethyl)amino benzenesulfonamide The desired product was prepared by substituting Example 54B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 587 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.53 (t, IH), 8.52 (d, IH), 7.99-7.86 (m, 4H), 7.69 (dd, 2H), 7.65 (d, 2H), 7.40 (d, 2H), 7.31 (t, 2H), 7.20 (t, IH), 7.00 (d, IH), 3.51 (dt, 2H), 3.28 (t, 2H), 2.63 (s, 3H). Example 87 4-((3.3-diphenylpropyl)amino -N-((4'-fluoro(l,r-biphenyl)-4-yl carbonyl -3- nitrobenzenesulfonamide The desired product was prepared by substituting 3,3-diphenyl-l-propanamine for 2,2-dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 627 (M+NHι) + ; 1H NMR (500 MHz, DMSO-de) δ 12.45 (br s, IH), 8.65 (d, IH), 8.61 (t, IH), 7.97 (d, 2H), 7.93 (dd, IH), 7.82-7.78 (m, 4H), 7.36-7.33 (m, 6H), 7.30-7.27 (m, 4H), 7.19-7.16 (m, 2H), 7.08 (d, IH), 4.12 (t, IH), 3.40 (d, IH), 3.37 (d, IH), 2.45 (d, IH), 2.42 (d, IH). Example 88 4-((2-(benzylsulfanyl)ethyl amino -N-((4'-fluoro(l,r-biphenyl -4-yl carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 2-(benzylsulfanyl)ethanamine and Example ID for cyclohexylamine and Example IC, respectively, in Example 3 A. MS (ESI(- )) m/e 564 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.54 (d, IH), 8.52 (t, IH), 7.96 (d, 2H), 7.90 (dd, IH), 7.73 (m, 2H), 7.62 (t, 2H), 7.37-7.20 (m, 7H), 7.00 (d, IH), 3.81 (s, 2H), 3.56 (dt, 2H), 2.70 (t, 2H). Example 89 N-r^'-fluoroCLl'-biphenvDA-yncarbonvD-S-nitro^-fS- (phenylsulfanyl)ρropoxy)benzenesulfonamide Example 89A N-((4'-fluoro(l '-biphenyl)-4-yl)carbonyl)-4-(3-hydroxypropoxy)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 1,3-propanediol for ethylene glycol in Example 75A. MS (ESI(-)) m/e 473 (M-H) " . Example 89B N-((4'-fluαro( 1.1 '-biphenyl)-4-yl)carbonyl)-3-nitro-4- 3- (phenylsulfanyl)propoxy)benzenesulfonamide The desired product was prepared by substituting Example 89A for Example 27A in Example 27B. MS (ESI(-)) m/e 565 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.29 (d, IH), 8.06 (dd, IH), 7.96 (d, 2H), 7.74 (dd, 2H), 7.62 (d, 2H), 7.39-7.24 (m, 7H), 7.14 (tt, IH), 4.29 (t, 2H), 3.13 (t, 2H), 2.02 (m, 2H). Example 90 N-((4'-fluoro(l,r-biphenyl)-4-yl carbonyl)-4-(3-((2-methylphenyl)sulfanyl)propoxy)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 2-methylbenzenethiol and Example 89A for thiophenol and Example 27A, respectively, in Example 27B. MS (ESI(-)) m/e 579 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.31 (d, IH), 8.06 (dd, IH), 7.96 (d, 2H), 7.74 (dd, 2H), 7.63 (d, 2H), 7.38 (d, IH), 7.28 (t, 3H), 7.16 (dd, 2H), 7.05 (td, IH), 4.31 (t, 2H), 3.10 (t, 2H), 2.26 (s, 3H), 2.04 (m, 2H). Example 91 N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl carbonyl)-3-nitro-4-(3-((2- (trifluoromethyl)phenyl sulfanyl propoxy benzenesulfonamide The desired product was prepared by substituting 2-trifluoromethylbenzenethiol and Example 89A for thiophenol and Example 27A, respectively, in Example 27B. MS (ESI(-)) m/e 633 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.31 (d, IH), 8.06 (dd, IH), 7.96 (d, 2H), 7.77-7.70 (m, 3H), 7.69-7.54 (m, 4H), 7.38 (m, 2H), 7.28 (t, 2H), 4.30 (t, 2H), 3.24 (t, 2H), 2.05 (m, 2H). Example 92 4-(3-((2,4-difluorophenyl)sulfanyl propoxy)-N-((4'-fluoro(l.r-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 2,4-difluorobenzenethiol and Example 89A for thiophenol and Example 27A, respectively, in Example 27B. MS (ESI(-)) m/e 601 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.28 (d, IH), 8.07 (dd, IH), 7.96 (d, 2H), 7.74 (dd, 2H), 7.62 (d, 2H), 7.59-7.48 (m, IH), 7.38 (d, IH), 7.35-7.25 (m, 3H), 7.12-7.04 (m, IH), 4.29 (t, 2H), 3.08 (t, 2H), 1.97 (m, 2H). Example 93 N-((4'-fluoro( 1.1 '-biphenyl)-4-yl)carbonyl)-4-(neopentylamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting 2,2-dimethyl- 1-propanamine for 2,2-dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 486 (M+H) + ; ! H NMR (500 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.70 (d, IH), 8.58 (t, IH), 7.99 (dd, IH), 7.97 (d, 2H), 7.81 (2d, 4H), 7.38 (d, IH), 7.34 (t, 2H), 3.30 (d, 2H), 1.02 (s, 9H). Example 94 4-f 2-adamantylamino)-N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 2-adamantanamine hydrochloride for 2-aminoborane hydrochloride in Example 13. MS (APCI(+)) m/e 550 (M+H) + ; 1H NMR (500 MHz, DMSO-de) δ 12.45 (br s, IH), 8.83 (d, IH), 8.70 (d, IH), 7.98 (dd, IH), 7.95 (d, 2H), 7.78 (2d, 4H), 7.32 (t, 2H), 7.30 (d, IH), 4.01 (m, IH), 2.04-1.65 (m, 14H). Example 95 4-(( 1 -adamantylmethyl amino)-N-(4-( 1 -isopropyl-2-methyl- 1 H-benzimidazol-5-yl)benzoyl)- 3 -nitrobenzenesulfonamide Example 95A methyl 4'-fluoro-3 '-nitro( 1 , 1 '-bipb.enyD-4-carboxylate The desired product was prepared by substituting 4-bromo-l-fluoro-2-nitrobenzene for Example 5 A in Example 5B. Example 95B methyl 4-(l-ethyl-2-methyl-lH-benzimidazol-5-yl)benzoate A room temperature solution of Example 95A (275 mg, 1.0 mmol) in isopropylamine (2 mL) was stirred for 16 hours and concentrated. The concentrate was suspended in dichloromethane (5 mL) and filtered through a pad of silica gel (5 g) with 1 : 1 dichloromethane/diethyl ether, and concentrated. The concentrate was dissolved in ethyl acetate (5 mL), treated with 10% Pd/C (100 mg), then stirred under a hydrogen atmosphere for 3 hours. The mixture was filtered through a pad of silica gel (10 g) with ethyl acetate and concentrated. The concentrate was dissolved in acetic acid (5 mL), treated with acetic anhydride (0.5 mL), heated to reflux, stirred for 16 hours, and concentrated. The concentrate was dissolved in ethyl acetate (50 mL), washed sequentially with saturated NaHCO 3 , water, and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 2-8 % methanol/dichloromethane to provide the desired product. MS (DCI) m/e 309 (M+H) + . Example 95C 4-((l-adamantylmethyl)an ino)-N-(4-(l-isopropyl-2-methyl-lH-benzimidazol-5-yl benzoyl)- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 95B and Example 28A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 640 (M-H) " ; H NMR (400 MHz, DMSO-de) δ 8.52 (d, IH), 8.39 (t, IH), 7.95 (d, 2H), 7.89 (dd, IH), 7.78 (s, IH), 7.70 (d, IH), 7.62 (d, 2H), 7.48 (d, IH), 7.16 (d, IH), 4.75 (m, IH), 3.12 (d, 2H), 2.57 (s, 3H), 1.97 (m, 3H), 1.73-1.50 (m, 18H). Example 96 N-((4'-fluoro( 1 , 1 '-biphenyl)^-yl)carbonyl)-3-ni ro^-( (2- . (phenylsulfanyl)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting 2-(phenylsulfanyl)ethanamine for 2,2-dimethylcyclopentylamine in Example IE. MS (APCI(+)) m/e 569 (M+NH 4 ) + ; H NMR (500 MHz, DMSO-d 6 ) δ 12.40 (br s, IH), 8.68 (t, IH), 8.53 (d, IH), 7.86 (d, 2H), 7.84 (dd, IH), 7.69 (2d, 4H), 7.27 (dd, 2H), 7.22 (t, 2H), 7.17 (t, 2H), 7.12 (d, IH), 7.08 (t, IH), 3.60- 3.56 (m, 2H), 3.21-3.18 ( , 2H). Example 97 N-(4-( 1 -cyclohexen- 1 -yl benzoyl -3-nitro-4-((2- (phenylsulfanyl)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 9A and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 536 (M-H) " ; ! H NMR (400 MHz, CD 3 OD) δ 8.77 (d, IH), 7.99 (dd, IH), 7.77 (d, 2H), 7.47 (d, 2H), 7.38 (m, 2H), 7.20 (m, 2H), 7.14 (m, IH), 7.02 (d, IH), 6.27 (m, IH), 3.67 (t, 2H), 3.27 (t, 2H), 2.41 (m, 2H), 2.22 (m, 2H), 1.79 (m, 2H), 1.67 (m, 2H). Example 98 4-(cyclohexyloxy)-N-((4'-fluoro(l,r-biphenyl)-4-yl)carbonyl)-3- (trifluoromethyl)benzenesulfonamide Example 98A 4-chloro-3-(trifluoromethyl)benzenesulfonamide A -10 °C solution of 4-chloro-3-(trifluoromethyl)aniline (5.37 g, 27.5 mmol) in acetic acid (25 mL) and concentrated HCl (30 mL) was treated with a solution of NaNOo (2.09 g, 30.3 mmol) in water (10 mL), stirred for 20 minutes, and poured into a saturated solution of SO 2 and CuCl 2 -2H 2 O (1.70 g, 10 mmol) in acetic acid (80 mL) and water (10 mL). The reaction was stirred for 1 hour, poured into ice, and extracted with dichloromethane. The combined extracts were washed with brine and concentrated. The concentrate was dissolved in saturated NH 4 OH (150 mL) and THF (150 mL), stirred for 30 minutes, and extracted with ethyl acetate. The combined extracts were washed with brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 277 (M+NH 4 ) + . Example 98B 4-(cyclohexyloxy -3-(trifluoromethyl)benzenesulfonamide A 0 °C solution of KH (8.7 g, 76.0 mmol) in DMF (100 mL) was treated with cyclohexanol (8.02 mL, 76.0 mmol) over 10 minutes, then treated with 18-crown-6 (7.9 g, 30.0 mmol) and Example 98A (3.95 g, 15.2 mmol), heated to 100 °C, and stirred for 30 minutes. The reaction was cooled to room temperature,, quenched with IM HCl, and extracted with ethyl acetate. The combined extracts were washed with water and brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI) m e 322 (M-H) " . Example 98C 4-(cyclohexyloxy)-N-((4'-fluoro( 1 , 1 '-biphenyiy4-yl)carbonyι)-3- (trifluoromethyPbenzenesulfonarnide The desired product was prepared by substituting Example 98B for Example IC in Example ID. MS (ESI(-)) m/e 520 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.28 (d, IH), 8.20 (dd, IH), 8.15 (d, 2H), 7.99 (d, 2H), 7.90 (d, 2H), 7.78 (dd, IH), 7.56 (d, IH), 4.79 (m, IH), 2.82 (s, 3H), 1.88 (m, 2H), 1.65 (m, 4H), 1.43 (m, 4H). Example 99 4-(cyclohexyloxy)-N-(4-(2-methyl- 1 ,3-benzothiazol-5-yl)benzoyl)-3- (trifluoromethypbenzenesulfonamide The desired product was prepared by substituting Example 98B and Example 17A for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 573 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.19 (d, IH), 8.08 (m, 2H), 7.99 (d, 2H), 7.73 (m, 4H), 7.31 (d, IH), 4.65 (m, IH), 2.82 (s, 3H), 1.87 (m, 2H), 1.75-1.35 (m, 8H). Example 100 4-((cyclohexylmethyl)amino)-N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3-nitro-5- vinylbenzenesulfonamide Example 100A 4-((cyclohexylmethyl)amino -3-nitro-5-vinylbenzenesulfonamide The desired product was prepared by substituting tributyl(vinyl)stannane for 2- (tributylstannyl)pyrimidine in Example 26B. MS (ESI) m/e 338 (M-H) " . Example 100B 4-((cyclohexylmethyl)amino)-N-((4'-fluoroπ,r-biphenyl)-4-yl)carbonyl)-3-nitro-5- vinylbenzenesulfonamide The desired product was prepared by substituting Example 100A for Example IC in Example ID. MS (ESI) m/e 536 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.39 (d, IH), 7.98-7.93 (m, 3H), 7.74 (dd, 2H), 7.61 (d, 2H), 7.47 (t, IH), 7.28 (t, 2H), 6.92 (dd, IH), 5.65 (d, IH), 5.40 (d, IH), 3.18 (t, 2H), 1.70-1.53 (m, 5H), 1.25-1.04 (m, 3H), 0.94-0.80 (m, 3H). Example 101 4-((2-((2,6-dimethylphenyl sulfanyl)ethyl amino -N-((4'-fluoroπ '-biphenyl)-4- vD carbonyl) -3 -nitrobenzenesulfonamide The desired product was prepared by substituting 2,6-dimethylbenzenethiol and Example 78A for thiophenol and Example 27 A, respectively, in Example 27B. MS (ESI) m/e 578 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.53 (d, IH), 8.48 (t, IH), 7.95 (d, 2H), 7.85 (dd, IH), 7.73 (dd, 2H), 7.62 (d, 2H), 7.28 (t, 2H), 7.19-7.09 (m, 3H), 6.83 (d, IH), 3.45 (dt, 2H), 2.97 (t, 2H), 2.46 (s, 6H). Example 102 4-((2-((2-bromophenyl)sulfanyl)ethyl amino)-N-((4'-fluoro(l,r-biphenyl)-4-yl carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 2-bromobenzenethiol and Example 78A for thiophenol and Example 27 A, respectively, in Example 27B. MS (ESI(-)) m/e 628 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.61 (t, IH), 8.56 (d, IH), 7.98-7.89 (m, 3H), 7.75 (dd, 2H), 7.64 (d, 2H), 7.59 (dd, IH), 7.52 (dd, IH), 7.36 (td, IH), 7.28 (t, 2H), 7.15-7.06 (m, 2H), 3.68 (dt, 2H), 3.27 (t, 2H). Example 103 N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-4-((2-methyl-2-(phenylsulfanyPpropyl)amino -3- nitrobenzenesulfonamide Example 103 A methyl (phenylsulfanyl)acetate A room temperature solution of (phenylsulfanyl)acetic acid (8.4 g, 50.0 mmol) in methanol (100 mL) was treated with chlorotrimethylsilane (13 mL, 100.0 mmol), stirred for 16 hours, and concentrated. The concentrate was dissolved in 5: 1 /hexanes: diethyl ether, filtered through a pad of sihca gel (80 g), rinsed with 5: 1 /hexanes: diethyl ether, and concentrated to provide the desired product. Example 103B methyl 2-methyl-2-(phenylsulfanyl)propanoate A -78 °C solution of Example 103A (911 mg, 5.0 mmol) and iodomethane (2.2 g, 15.0 mmol) in THF (20 mL) was treated with l.OM sodium hexamethyldisilazide in THF (11 mL, 11.0 mmol), warmed to room temperature over 16 hours, diluted with hexanes (50 mL), filtered through a pad of sihca gel, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 5% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 211 (M+H) + . Example 103C 2-methyl-2-(phenylsulfanyl)- 1 -propanol A -78 °C solution of Example 103B (860 mg, 4.1 mmol) in dichloromethane (10 mL) was treated with 1.0M DIBAL-H in toluene (11 mL), warmed to room temperature over 4 hours, poured into a mixture of 3M HCl (15 mL) and ice (~10 g), and extracted with ethyl acetate (100 mL). The combined extracts were washed with IM HCl (10 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10-30% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 183 (M+H) + . Example 103D 2-methyl-2-(phenylsulfanyl)propylamine The desired product was prepared by substituting Example 103C for Example 7 A in Examples 7B and 7C. Example 103E N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-4-((2-methyl-2-(phenylsulfanyl)propyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 103D for Example 7C in Example 7D. MS (ESI(-)) m/e 578 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.55 (m, 2H), 8.00 (d, 2H), 7.91 (d, IH), 7.86 (dd, IH), 7.78 (m, 4H), 7.51-7.25 (m, 6H), 7.00 (m, 2H), 3.55 (s, 2H), 1.57 (s, 6H). Example 104 N-((4'-fluoro(l .1 , -biphenyl)-4-yl carbonyl -3-nitro-4-((l- (phenylsulfanyl)cycloheptyl)methoxy)benzenesulfonamide Example 104A methyl 1 -(phenylsulfany cycloheptanecarboxylate A -78 °C solution of Example 104A (911 mg, 5.0 mmol) and 1,6-dnodohexane (845 mg, 2.5 mmol) in THF (70 mL) was treated with 1.0M sodium hexamethyldisilazide in THF (15 mL), warmed to room temperature over 16 hours, diluted with hexanes (50 mL), filtered through a pad of silica gel, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 2-5% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 265 (M+H) + . Example 104B ( 1 -(phenylsulfanyl) cy cloheptyDmethanol The desired product was prepared by substituting Example 104A for Example 103B in Example 103C. MS (DCI) m/e 237 (M+H) + . Example 104C N-((4'-fluoro( 1 , 1 '-biphenyl)-4-yl)carbonyl)-3-nitro-4-(( 1 - (phenylsulfanyl)cycloheptyl)methoxy)benzenesulfonamide A room temperature solution of Example 104B (117 mg 0.50 mmol) and Example ID (100 mg, 0.23 mmol) in THF (3 mL) was treated with 60% sodium hydride dispersion in oU(80 mg, 2.0 mmol), stirred for 16 hours, dUuted with ethyl acetate (50 mL), washed sequentially with IM HCl (5 mL), water (5 mL), and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 633 (M- H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.46 (d, IH), 8.20 (dd, IH), 8.00 (d, 2H), 7.97 (d, 2H), 7.79 ( , 4H), 7.58 (d, IH), 7.45 (m, 2H), 7.40-7.28 (m, 5H), 4.06 (s, 2H), 1.90-1.50 (m, 12H). Example 105 4-(( 1 -adamantylmethyl)amino)-N-((2'-methoxy( 1 , 1 '-biphenyl)-4-yl) carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 21 A and Example 28 A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 574 (M-H) " ; H NMR (400 MHz, DMSO-de) δ 8.67 (d, IH), 8.59 (t, IH), 7.94 (dd, IH), 7.89 (dt, 2H), 7.58 (dt, 2H), 7.39 (m, 2H), 7.31 (dd, IH), 7.24 (dd, IH), 7.05 (dt, IH), 3.76 (s, 3H), 3.19 (d, 2H), 2.00-1.55 (m, 15H). Example 106 N-(T2'-methoxyπ .1 '-biphenvP-4-vPcarbonvP-3-nitro-4-((2- . (phenylsulfanyl)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 21 A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 562 (M-H) " ; 1H NMR (400 MHz, DMSO-de) δ 8.79 (t, IH), 8.52 (d, IH), 7.93 (dd, IH), 7.89 (d, 2H), 7.58 (d, 2H), 7.40-7.00 (m, lOH), 3.76 (s, 3H), 3.67 (q, 2H), 3.28 (t, 2H). Example 107 N-((4'-fluoro(Ll'-biphenvP-4-ypcarbonvP-3-nitro-4-((2-(2- pyridinylsulfanyp ethyl) amino)benzenesulfonamide The desired product was prepared by substituting 2-pyridinethiol and Example 78A for thiophenol and Example 27A in Example 27B. MS (ESI(-)) m/e 551 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.72 (t, IH), 8.58 (d, IH), 8.51-8.47 (m, IH), 8.01 (dd, IH), 7.96 (d, 2H), 7.76 (dd, 2H), 7.69 (d, 2H), 7.64 (td, IH), 7.44 (d, IH), 7.35-7.25(m, 3H), 7.16-7.09 (m, IH), 3.72 (dt, 2H), 3.42 (t, 2H). Example 108 3-nitro-N-( ' 4-π-oxo-2.3-dihvdro-lH-inden-5-yPbenzoyP-4-( ' ( ' 2- (phenylsulfanvP ethyl) amino benzenesulfonamide Example 108A 3-nitro-4-((2-(phenylsulfanyl)ethvParmno -N-(4-(4,4.5.5-tettamethyl-1.3,2-dioxaborolan-2- vPbenzoyPbenzenesulfonamide The desired product was prepared by substituting Example 77B for Example 3 A in Example 3C. MS (ESI(-)) m/e 582 (M-H) " . Example 108B 3-nitro-N-(4-( 1 -oxo-2.3 -dihvdro- 1 H-inden-5-vPbenzovP-4-((2- phenylsulfanyPethyl)amino)benzenesulfonamide The desired product was prepared by substituting 5-bromo-l-indanone and Example 108 A for 4-bromo-l-iodobenzene and Example 3C, respectively, in Example 3D. MS (ESI(- )) m/e 586 (M-H) " ; ! H NMR (300 MHz, DMSO-d 6 ) δ 8.51 (d, IH), 8.50 (t, IH), 7.98 (m, 2H), 7.89 (m, 2H), 7.71 (m, 4H), 7.40 (d, 2H), 7.31 (t, 2H), 7.20 (t, 2H), 6.98 (d, IH), 3.60 (t, 2H), 3.27 (t, 2H), 3.15 (t, 2H), 2.67 (t, 8H). Examples 109-1 and 109-2 N- 4- 3.4.4a.5.6.7.8.8a-octahvdro-l-naphthalenvPbenzovP-3-nitro-4-((2- (phenylsulfany ethyl) amino tbenzenesulfonamide and N-(4-(2.3.4.4a.5.6.7.8-octahvdro-l-naphthalenvPbenzoyP-3-nitro-4-((2- (phenylsulfanyPethyPamino)benzenesulfonamide The desired product was prepared by substituting Example and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 590 (M-H) " ; H NMR (400 MHz, DMSO-de) δ 8.77 (t,lH), 8.60 (d, IH), 7.92 (dd, IH), 7.80 (d, 2H), 7.36 (d, 2H), 7.40-7.15 (m, 6H), 5.80 (m, IH), 3.67 (q, 2H), 3.30 (t, 2H), 2.30-2.20 (m, 3H), 1.80- 1.60 (m, 5H), 1.40-1.20 (m, 6H). Example 110 N- 4-π.4.4a-5.6.7.8.8a-octahvdro-2-naphthalenyPbenzovP-3-nitro-4-((2- (phenylsulfanyP ethyl) amino tbenzenesulfonamide and N-(4-(3.4.4a,5.6.7,8.8a-octahydro-2-naphthalenvPbenzovP-3-nitro-4-((2- (phenylsulfanyPethyPammo)benzenesulfonamide The desired product was prepared by substituting Example 57A and Example 78B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 590 (M-H) " ; 1H MR (400 MHz, DMSO-de) δ 8.77 (t, IH), 8.60(d, IH), 7.92 (dd, IH), 7.82 (d, 2H), 7.50 (d, 2H), 7.40-7.15 (m, 6H), 6.25 (m, IH), 6.18(m, IH), 3.67 (q, 2H), 3.30 (t, 2H), 2.40 (m, 3H), 1.70-1.20 (m, 12H). Example 111 N-(4-decahydro-l-naphthalenylbenzoyl)-3-nitro-4-((2- (phenylsulfanypethypamino)benzenesulfonamide The desired product was prepared by substituting Example 59A and Example 77B for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 592 (M-H) " ; H NMR (400 MHz, DMSO-de) δ 8.77 (t,lH), 8.60 (d, IH), 7.92 (dd, IH), 7.78 (d, 2H), 7.45 (d, IH), 7.37 (d, 2H), 7.30-7.15 (m, 5H), 3.67 (q, 2H), 3.30 (t, 2H), 2.35 (m, IH), 1.70-1.20 (m, 16H). Example 112 The desired product was prepared by substituting Example 60A and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 592 (M-H) " ; 1H NMR (400 MHz, DMSO-de) δ 8.77 (t,lH), 8.60 (d, IH), 7.92 (dd, IH), 7.80 (d, 2H), 7.45 (d, IH), 7.37 (d, 2H), 7.30-7.15 (m, 5H), 3.67 (q, 2H), 3.30 (t, 2H), 2.55 (m, IH), 1.70-1.20 (m, 16H). Example 113 3-nitro-4-((2-(phenylsulfanyl)ethyPamino -N-(4-(5,6,7,8-tetrahvdro-l- naphthalenypbenzoypbenzenesulfonamide Example 113A methyl 4-(5,6 1 7,8-tetrahydro-l-naphthalenyl)benzoate The desired product was prepared by substituting 5,6,7,8-tetrahydro-l-naphthalenol for 4-tert-butylcyclohexanone in Examples 5A and 5B. MS (DCI) m/e 267 (M+H) . Example 113B 3-nitro-4-((2-(phenylsulfanyPethyPamino -N-(4-(5,6,7,8-tetrahydro-l- naphthalenyPbenzovPbenzenesulfonamide The desired product was prepared by substituting Example 113A and Example 77A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 586 (M-H) " ; X H NMR (400 MHz, DMSO-d 6 ) δ 8.77 (t,l H), 8.62 (d, IH), 7.92 (dd, IH), 7.90 (d, 2H), 7.40-7.18 (m, 10H), 6.95 (dd, IH), 3.67 (q, 2H), 3.30 (t, 2H), 2.80 (t, 2H), 2.49 (t, 2H), 1.75- 1.60 (m, 4H). Example 114A 1 -bromo-4-fluoro-2-methoxybenzene A mixture of 2-bromo-5-fluorophenol (2 mL, 17.8 mmol)), sodium hydride (0.5 g, 20.8 mmol) and iodomethane (5 mL, 82 mmol) in DMF (20 mL) was heated to 60 °C, stirred for 16 hours, diluted with ethyl acetate (100 mL), washed sequentially with IM HCl,. water, and brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. Example 114B methyl 4'-fluoro-2'-methoxy( 1 , 1 '-biphenyl)-4-carboxylate The desired product was prepared by substituting Example 114A for Example 5A in Example 5B. MS (DCI) m/e 262 (M+H) + . Example 114C 4-((l-adamantylmethyPamino -4'-fluoro(l,l'-biphenyl)-4-yl)carbonyl)- 2'-methoxy-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 114B and Example 28 A for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 592 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.56 (t, IH), 7.92 (m, 3H), 7.52 (m, 2H), 7.33 (m, 2H), 7.05 (dd, IH), 6.86 (m, IH), 3.59 (s, 3H), 3.18 (d, 2H), 2.46 (s, 6H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 115 4-((2-(phenylsulfanyPethvPamino)-4'-fluoro(l,r-biphenyP-4-yl)carbonyP- 2'-methoxy-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 114B and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 580 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.79 (t, IH), 8.52 (d, IH), 7.93 (dd, IH), 7.89 (d, 2H), 7.58 (d, 2H), 7.40-7.19 (m, 7H), 7.05 (dd, IH), 6.86 (m, IH), 3.78 (s, 3H), 3.67 (q, 2H), 3.28 (t, 2H). Example 116 4-((2-(phenylsulfanyl)ethyl)amino)-4'-fluoiO(l , 1 '-biphenyl)-4-yl) carbonyl)- 2'-hydroxy-3- nitrobenzenesulfonamide A -78 °C solution of Example 115 (20 mg, 5.0 mmol) in dichloromethane (1 mL) was treated with 1.0M boron tribromide in dichloromethane (0.2 mL, 0.2 mmol), warmed to room temperature over 16 hours, dUuted with methanol (5 mL), and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50-100% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 566 (M-H) " ; H NMR (400 MHz, DMSO-de) δ 10.25 (s, IH) 8.79 (t, IH), 8.52 (d, IH), 7.93 (dd, IH), 7.89 (d, 2H), 7.61 (d, 2H), 7.40-7.19 (m, 6H), 6.73 (m, 2H), 3.67 (q, 2H), 3.28 (t, 2H). Example 117 4-((2-(phenylsulfanyPethvPamino)- ( 1 ,8'-quinoHne)-4-yPcarbonyP- 2'-hydroxy-3- nitrobenzenesulfonamide The desired product was prepared by substituting 8-bromoquinohne and Example 108A for 4-bromo-l-iodobenzene and Example 3C, respectively, in Example 3D. MS (ESI(- )) m/e 583 (M-H) " ; ! H NMR (400 MHz, DMSO-d 6 ) δ 8.89 (dd, IH), 8.79 (t, IH), 8.65 (d, IH), 8.45 (dd, IH), 8.05 (dd, IH), 7.99 (d, 2H), 7.83-7.70 (m, 4H), 7.59 (dd, IH), 7.38 (d, 2H), 7.30-7.19 ( , 4H), 3.69 (q, 2H), 3.28 (t, 2H). Example 118 4-(((lR)-5-(dimethylamino)-l-((phenylthio)methyl)pentyl)amino)-N-((2'-methoxy-4'-(3- morpholin-4-ylpropyl)- 1 , 1 '-biphenyl-4-yl)carbonyP-3-nitrobenzenesulfonamide A solution of Example 194 (128 mg, 0.153 mmol) and 37% aqueous formaldehyde (0.15 mL) in 1 : 1 methanol/dichloromethane (4 mL) at room temperature was treated with MP -sodium cyanoborohydride (0.32 g, 0.767 mmol (2.42 mmol/g) and stirred for 6 hours at room temperature. The resin was filtered and washed with dichloromethane and the resulting solution was concentrated. The concentrate was purified by reverse phase preparative HPLC (using a C-18 column and a solvent system increasing in gradient from 10% to 100% acetonitrile/water containing 0.1 % TFA) to provide the desired product. MS (ESI(-)) m/e 788 (M-H) " ; ! H NMR (500 MHz, DMSO-d 6 ) δ 10.4 (br s, IH), 9.5 (br s, IH), 8.56 (d, IH), 8.32 (d, IH), 7.92 (d, 2H), 7.90 (dd, IH), 7.59 (d, 2H), 7.28-7.23 (m, 4H), 7.17-7.09 (m, 3H), 7.01 (d, IH), 6.93 (dd, IH), 4.16-4.10 (m, IH), 3.97 (br s, 2H), 3.78 (s, 3H), 3.46 (br s, 2H), 3.41-3.33 (m, 2H), 3.16-3.12 (m, 2H), 3.08 (br s, 2H), 2.99 (br s, 2H), 2.73 (s, 3H), 2.72 (s, 3H), 2.69 (t, 2H), 2.06-2.01 (m, 2H), 1.82-1.76 (m, 2H), 1.60 (quint, 2H), 1.39-1.32 (m, 2H). Example 119 N-(4-(4,4-dimethylpiperidin- 1 -yPbenzovD-4-(Yf 1 RV3 -morphoHn-4-yl- 1 - ((phenyltMo)methyl)propyl)amino)-3-nitrobenzenesulfonamide Example 119 A ethyl 4-(4.4-dimemyl-2,6-dioxopiperidin-l-yl)benzoate A solution of ethyl 4-aminobenzoate (1.0 g, 6.1 mmol) and 3,3-dimethylglutaric anhydride (0.95 g, 6.7 mmol) in 1,2-dichloroethane (15 mL) was heated to reflux for 1 hour, cooled to room temperature, and treated dropwise with acetyl chloride (0.88 mL, 12.5 mmol). The mixture was heated to reflux for 1 hour, cooled to room temperature, diluted with dichloromethane, washed sequentially with water, saturated NaHCO 3 , and brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS(DCI(+)) m/e 290 (M+H) + . Example 119B ethyl 4-(4.4-dimethylpiperidin- 1 -vPbenzoate Example 119A was processed according to the procedure described in Liebigs Ann. Chem. 1919, p. 461 to provide the desired product. MS(DCI(+)) m/e 262 (M+H) + . Example 119C 4-f 4,4-dimethylpiperidin~ 1 -y benzoic acid A solution of Example 119B (260mg, 1.0 mmol) and LiOH-H 2 O (158mg, 4.0 mmol) in THF (19 mL), water (5 mL), and methanol (5 mL) was heated to 75 °C for 18 hours, cooled to room temperature, concentrated, and adjusted to pH 3-4 with IN HCl. The precipitate was collected by filtration, washed with water, and dried under vacuum to provide the desired product. MS(DCI(+)) m/e 234 (M+H) + . Example 119D N-(4-(4,4-cHmethylpiperidin- 1 -yl)benzoyl)-4-((( 1 R)-3 -morpholin-4-yl- 1 - ((phenylthio methyl)propyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Examples 119C and 463 A for Examples IB and IC, respectively, in Example ID. MS(ESI(+)) m/e 682 (M+H) + ; ^ MR (300 MHz, DMSO-d 6 ) δ 8.52 (d, IH), 8.40 (d, IH), 7.82 (dd, IH), 7.72 (d, 2H), 7.28 (dd, 2H), 7.27-7.07 (m, 4H), 6.89 (d, 2H), 4.15 (s, IH), 3.54 (s, 4H), 3.30-3.25 (m, 6H), 2.50-2.32 ( , 6H), 1.95-1.82 (m, IH), 2.08-1.98 (m, IH), 1.38 (t, 4H), 0.94 (s, 6H). Example 120 4-(((lR)-5-amino-l-((phenylthio)methyl)pentyl)amino)-N-(4-(2-azaspiro(4.4)non-2- yPbenzoyP-3-nitrobenzenesulfonamide Example 120A methyl 4-(l ,3-dioxo-2-azaspiro(4.4)non-2-yPbenzoate The desired product was prepared by substituting methyl 4-aminobenzoate and 2- oxapiro(4.4)nonane-l,3-dione for ethyl-4-aminobenzoate and 3,3-dimethylglutaric anhydride, respectively, in Example 119A. MS(DCI(+)) m/e 288 (M+H) + . Example 120B methyl 4-(2-azaspiro(4.4)non-2-yPbenzoate The desired product was prepared by substituting Example 120A for Example 119A in Example 119B. MS(DCI(+)) m/e 260 (M+H) + . Example 120C 4-(2-azaspiro(4.4)non-2-yl)benzoic acid The desired product was prepared by substituting Example 120B for Example 119B in Example 119C. MS(DCI(+)) m/e 246 (M+H) + . Example 120D tert-butvH5R -5-((4-(;((4-r2-azaspiro(4.4)non-2-vPbenzoyPamino)sulfonvP-2- nitrophenyl)amino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Examples 120C and 124C for Examples IB and IC, respectively, in Example ID. MS(ESI(-)) m/e 750 (M-H) " . Example 120E 4-(((lR)-5-amino-l-((phenylthio methyl)pentyPamino)-N-(4-(2-azaspiro(4.4)non-2- yl)benzoyl)-3-nitrobenzenesulfonamide A solution of Example 120D (24mg, 0.03 mmol) and 4N HCl (0.5 mL) in dioxane at room temperature was stirred for 4 hours, partially concentrated, and treated with diethyl ether. The precipitate was filtered, washed with diethyl ether, and was dried under vacuum to provide the desired product. MS(ESI(+)) m/e 652 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.89 (s, IH), 8.52 (d, IH), 8.31 (d, IH), 7.86 (dd, IH), 7.74 (d, 2H), 7.70 (s, 2H), 7.24- 7.07 (m, 6H), 6.51 (d, 2H), 4.10 (m, IH), 3.57 (s, 4H), 3.35 (m, 4H), 3.18 (s, 2H), 2.74 (m, 2H), 1.86 (t, 2H), 1.76 ( , 2H), 1.65 (m, 4H), 1.55 (t, 4H). Example 121 4-(((lR)-3-(dimethylamino -l-((phenylthio)methyl propyl)amino -N-(4-(4,4- dimethylpiperidinrl-yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Examples 119C and 122G for Examples IB and IC, respectively, in Example ID. MS(ESI(+)) m/e 640 (M+H) + ; H NMR (300 MHz, DMSO-de) δ 8.46 (d, IH), 8.23 (d, IH), 7.81 (dd, IH), 7.72 (d, 2H), 7.82-7.15 (m, 5H), 6.91 (d, 2H), 6.82 (d, 2H), 4.08 (m, IH), 3.35 (m, 2H), 3.21 (t, 4H), 2.9 (m, 2H), 2.56 (s, 6H), 2.04 (m, 2H), 1.39 (t, 4H), 0.94 (s, 6H). Example 122 4- ((lRV3-(dimethylamino -l-((phenylthio)methyl propyPamino)-N-((2'-methoxy-4'-(3- morphoHn-4-ylpropyP- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide Example 122A tert-butyl (3R)-3-(((9H-fluoren-9-ylmethoxy)carbonyl)amino)-4-hydroxybutanoate A solution of Fmoc-D-Asρ(OtBu)-OH (9.0g, 21.8 mmol) andN.N- diisopropylethylamine (4.6 mL) in THF (100 mL) at -40 °C was treated with isobutyl chloroformate (3.1 mL, 24.1 mmol), warmed to 0 °C over 30 minutes, cooled to -20 °C, and treated slowly with sodium borohydride (1.64 g, 43.6 mmol) and methanol (10 mL). The reaction was gradually warmed to room temperature over 2 hours, diluted with ethyl acetate (200 mL), washed with water (100 mL) and brine (50 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (ESI(+))m/e 398 (M+H) . Example 122B tert-butyl (3R)-3-(((9H-fluoren-9-ylmethoxy carbonyl)arnino)-4-(phenylthio)butanoate The desired product was prepared by substituting Example 122A for Example 27A in Example 27B. MS (ESI(+)) m/e 490 (M+H) + . Example 122C 4-fluoro-3-nitrobenzenesulfonamide A mixture of 2-fluoronitrobenzene (141 g, 1.0 mol) and chlorosulfonic acid (300 mL) was heated to 60 °C for 10 hours, cooled to room temperature, and slowly poured over ice (about 1 kg). The mixture was extracted with ether (4 L) and the combined extracts were concentrated to a final volume of approximately 2 L. The solution was cooled to -40 °C and treated with concentrated ammonium hydroxide (300 mL) at such a rate as to maintain an internal temperature of <10 °C. The mixture was separated and the aqueous phase was extracted with ethyl acetate (2 L). The combined organic phase and extracts were washed with 4M HCl (300 mL) and brine (100 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was crystallized from ethyl acetate/hexane to provide the desired product. Concentration of the mother Hquor and crystaUization of the concentrate provided additional product. MS (ESI(-)) m/e 219 (M-H) ~ . Example 122D tert-butyl (3R)-3-((4-(aminosulfonyl)-2-nitrophenyl)amino -4-(phenylthio)butanoate A mixture of Example 122B (600 mg, 1.23 mmol), Example 122C (298 mg, 1.34 mmol), andN.N-dHsopropylethylamine (3 mL) in DMF (3 mL) at 60 °C was stirred for 12 hours, diluted with ethyl acetate (100 mL), washed with water (45 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 30% ethyl acetate/dichloromethane to provide the desired product. MS (ESI(+)) m/e 468 (M+H) + . Example 122E (3R)-3-((4-(aminosulfonyl)-2-nitrophenyl)amino)-4-(phenylthio butanoic acid A mixture of Example 122D and 4M HCl in 1,4-dioxane (10 mL) was stirred at 50 °C for 5 hours and concentrated to provide the desired product. MS (ESI(+)) m/e 412 (M+H) . Example 122F (3R)-3-((4-(aminosulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio butanamide A solution of Example 122E (411 mg, 1 mmol), 2M dimethylamine in THF (1 mL), EDCI (296 mg, 1.5 mmol), and DMAP ( 10 mg ) in DMF ( 10 mL) at room temperature was stirred for 16 hours, diluted with ethyl acetate (200 mL), washed sequentially with IN HCl (50 mL), water (50 mL), and brine (20 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 100% ethyl acetate to provide the desired product. MS (ESI(+)) m/e 439 (M+H) . Example 122G 4-(((lR -3-(dimethylamino)-l-((phenylthio methyl propypamino -3- nitrobenzenesulfonamide A mixture of Example 122F (4.06 g, 9.25 mmol ) and IM borane in THF (20 mL) at room temperature was stirred for 16 hours, treated with methanol (5.0 mL) and concentrated HCl (2 mL), stirred at 80 °C for 3 hours, cooled to room temperature, adjusted to pH >7 with 4M sodium carbonate, dUuted with ethyl acetate (150 mL), washed with water (50 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 20% methanol/dichloromethane to provide the desired product. MS (ESI(+)) m/e 425 (M+H) + . Example 122H 4-formyl-2-methoxyphenyl trifluoroacetate A solution of vanUlin (5.0 g, 32.9 mmol), N,N-phenyl(trifluoromethanesulfonimide (36 mmol), and triethylamine (36 mmol) in dichloromethane (100 mL) was stirred at room temperature overnight. The reaction mixture was dUuted with ether (100 mL), filtered through sUica gel (100 g), rinsed with a mixed solvent of ether/dichloromethane and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 285 (M+H) . Example 1221 methyl 4'-formyl-2'-methoxy-l , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 122H for Example 5A in Example 5B. MS (DCI(+)) m/e 288 (M+H) + . Example 122J methyl 4'-(( lE)-3-tert-butoxy-3-oxoprop- 1 -enyl)-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylate A mixture of (tert-butoxycarbonylmethylene)triphenylphospharane (2.25 g, 5.5 mmol) and Example 1221 (1.35 g, 5.0 mmol) in THF (20 mL) at room temperature was stirred for 3 hours, diluted with hexanes (30 mL), and filtered through sihca gel (50 g). The silica gel was rinsed with 50% dichloromethane/ether and the combined solutions were concentrated to provide the desired product. MS (ESI(-)) m/e 367 (M-H) ~ . Example 122K methyl 4'-(3-tert-butoxy-3-oxopropyl)-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 122J for Example 5B in Example 5C. MS (ESI(-)) m/e 369 (M-H) " . Example 122L 3-(2-methoxy-4'-(methoxycarbonyP- 1 , 1 '-biphenyl-4-yppropanoic acid The desired product was prepared by substituting Example 122K for Example 122D in Example 122E. Example 122M methyl 2'-methoxy-4'-(3-morphoUn-4-yl-3-oxopropyl)-l , 1 '-biphenyl-4-carboxylate A solution of Example 122L (500 mg, 1.59 mmol) in dichloromethane (5 mL) was treated with 2M oxalyl chloride in dichloromethane (1 mL) and a drop of DMF, stirred for 1 hour, concentrated under vacuum, and dissolved in dichloromethane (5 mL). The mixture was treated with morphohne (0.5 mL) and the resulted slurry was filtered through sUica gel (10 g). The sUica gel was rinsed with ethyl acetate and concentrated. The concentrate was purified by flash column chromatography on silica gel with 30% ethyl acetate/hexanes to provide the desired product. MS (ESI(+)) m/e 384 (M+H) + . Example 122N methyl 2'-methoxy-4'-(3-morphoUn-4-ylpropyl)- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 122M for Example 122F in Example 122G. MS (ESI(+)) m/e 369 (M+H) + . Example 1220 2'-methoxy-4'-(3-morphohn-4-ylpropyl)- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 122N for Example 1 A in Example IB. Example 122P 4-(((lR)-3-(dimethylamino)-l-((phenyltMo)methyPpropyl)amino)-N-((2'-methoxy-4'-(3- morpholin-4-ylpropyl)-l,r-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Examples 1220 and 122G for Example IB and IC, respectively, in Example ID. MS (ESI(-)) m e 760 (M-H) " ; 1H NMR (500 MHz, CD 3 OD) δ 8.73 (d, IH), 8.31 (d, IH), 7.99 (dd, IH), 7.86 (d, 2H), 7.60 (d, 2H), 7.28-7.25 (m, 3H), 7.09 (m, 4H), 7.00 (s, IH), 6.94 (d, IH), 4.22 (m, IH), 4.03 (m, 2H), 3.81 (s, 3H), 3.74 (t, IH), 3.58 (t, IH), 3.49 (m, 2H), 3.42 (dd, IH), 3.25 (m, 3H), 3.18 (m, 3H), 3.14 (m, IH), 2.88 (s, 6H), 2.78 (t, 2H), 2.30 (m, IH), 2.22 (m, IH), 2.14 (m, 2H). Example 123 4-((( 1 R - 5-amino- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(4-ethyl-4-methylpiperidin- 1 - ypbenzovP-3-nitrobenzenesulfonamide Example 123 A methyl 4-(4-ethyl-4-methyl-2,6-dioxopiperidin- 1 -ypbenzoate The desired product was prepared by substituting 3-ethyl-3-methylglutaric anhydride and methyl 4-aminobenzoate for 3,3-dimethylglutaric anhydride and ethyl 4-aminobezoate, respectively, in Example 119A. MS(DCI(+)) m/e 290 (M+H) + . Example 123B methyl 4-(4-ethyl-4-methylpiperidin- 1 -ypbenzoate The desired product was prepared by substituting Example 123 A for Example 119A in Example 119B. MS(DCI(+)) m/e 262 (M+H) + . Example 123C 4-(4-ethyl-4-methylpiperidin- 1 -y benzoic acid The desired product was prepared by substituting Example 123B for Example 119B in Example 119C. MS(DCI(+)) m/e 248 (M+H) + . Example 123D tert-butyl (5R)-5-((4-(((4-(4-ethyl-4-methylpiperidin- 1 -yl)benzoyPamino)sulfonyl)-2- nitrophenyl)amino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Examples 123C and 124C for Examples IB and IC, respectively, in Example ID. MS (ESI(-)) m/e 752 (M-H) " . Example 123E 4-((( lR)-5-amino- 1 -((phenylthio)methyPpentyl)amino)-N-(4-(4-ethyl-4-methylpiperidin- 1 - yPbenzoyP-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 123D for Example 120D in Example 120E. MS (ESI(-)) m/e 652 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 12.0 (s, IH), 8.54 (d, IH), 8.31 (d, IH), 7.86 (dd, IH), 7.75 (d, 2H), 7.10-7.25 (m, 6H), 6.94 (d, 2H), 6.82 (d, 2H), 4.10 (m, IH), 3.50 (m, 4H), 3.37 (m, 2H), 3.21 (m, 2H), 2.72 (m, 2H), 1.75 (m, 2H), 1. 52 (m, 2H), 1.38 (m, 4H), 1.29 (m, 2H), 0.90 (s, 3H), 0.80 (t, 3H). Example 124 N-(4-(8-azaspiro(4.5)dec-8-yl)benzoyP-4-((( lR -5-(dimethylamino)- 1 - ((phenylthio)methyl)pentyl)amino)-3-nitrobenzenesulfonamide Example 124A tert-butyl N-((5R)-5-(((9H-fluoren-9-ylmethoxy)carbonypamino -6-hydroxyhexyP carbamate A solution of Fmoc-D-Lys(BOC)-OH (2.102 g, 4.5 mmol) in DME (5 mL) at -15 °C was treated successively with N-methylmorphohne (0.56 mL, 5.0 mmol) and isobutyl chloroformate (0.7 mL, 5 mmol), stirred for 2 minutes, and filtered. The filter cake was washed with DME (3 x 5 mL) and the combined filtrate and washings were cooled to -5 °C and treated with NaBIL (0.3 g, 7.5 mmol) in water (5 mL) and additional water(250 mL) immediately afterwards. The mixture was stirred for 15 minutes and filtered. The filter cake was washed with water and dried to provide the desired product. MS (APCI) m/e 455 (M+H) + . Example 124B tert-butyl N-((5R -5-(((9H-fluoren-9-ylmethoxy)carbonyl)amino)-6-(phenylthio hexyl) carbamate A mixture of Example 124A (2.0 g, 4.4 mmol), PhSSPh (1.44 g, 6.6 mmol), andn- BU 3 P (1.65 mL, 6.6 mmol) in toluene (50 mL) at 80 °C was stirred for 18 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with 25% ethyl acetate/hexanes. MS (APCI) m/e 547 (M+H) + . Example 124C tert-butyl (5R)-5-((4-(aminosulfonyP-2-nitrophenyl)amino)-6-(phenylthio)hexylcarbamate A solution of Example 124B (0.65 g, 1.2 mmol), Example 122C (0.262 g, 1.2 mmol), and dnsopropylethylamine (0.5 mL) in DMSO (5 mL) at 50 °C was stirred for 18 hours, diluted with ethyl acetate (100 mL), washed with water and brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI) m/e 523 (M- H) " . Example 124D 9H-fluoren-9-ylmethyl ( 1 R)-5-(dimethylamino)- 1 -((phenylthio)methyppentylcarbamate A solution of Example 124B (1.36 g, 2.4 mmol) in dichloromethane (5 mL) and TFA (5 mL) was stirred at room temperature for 30 minutes, and concentrated. The concentrate was dissolved in acetic acid (1 mL) and 37% aqueous formaldehyde (5 mL), treated with IM NaCNBH 3 in THF (10 mL), stirred for 30 minutes, adjusted to pH 7 with aqueous NaHCO 3 , and extracted with ethyl acetate(3 x 100 mL). The combined extracts were washed with water and brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 48:48:4 ethyl acetate/dichloromethane/methanol to provide the desired product. MS (ESI) m/e 475 (M+H) + . Example 124E 4-((( 1 R)-5-(dimethylamino)- 1 -((phenylthio methvPpentvPamino - 3- nitrobenzenesulfonamide A solution of Example 124D (1.2 g, 2.5 mmol), Example 122C (0.66 g, 3.0 mmol), and diisopropylethylamine (1.0 mL) in DMSO (10 mL) was heated to 50 °C, stirred for 18 hours, dUuted with ethyl acetate (100 mL), washed with water and brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/dichloromethane to provide the desired product. MS (ESI) m e 453, 451 (M+H) + , (M-H) " . Example 124F N- 4-(8-azaspiro(4.5 dec-8-vPbenzovP-4-((πR)-5-(dimethylamino -l- ((phenyltMo)methyl)pentyl)amino)-3-nitrobenzenesulfonamide A mixture of Examplel24E (35 mg, 0.07 mmol), Example 257C (35 mg, 0.135 mmol), EDCI (50 mg, 0.28 mmol), and DMAP (50 mg, 0.35 mmol) in t-butanol (0.5 mL) and 1,2-dichloroethane (0.5 mL) at room temperature was stirred for 18 hours and concentrated. The concentrate was dissolved in 1 : 1 DMSO/methanol (1 mL) and purified by preparative HPLC (using a C-18 column and a solvent system increasing in gradient from 10-95% acetontrile/water containing 0.1% TFA). The purified product was dissolved in 1: 1 dichloromethane/methanol, treated with 2M HCl in diethyl ether (1 mL), and concentrated to provide the hydrochloride salt. MS (ESI) m/e 694 (M+H) + , m/e 692 (M-H) " . H NMR (500 MHz, DMSO-de) δ 10.01 (m, IH), 8.54 (d, IH), 8.30 (d,lH), 7.87 (dd, IH), 7.75 (d, 2H), 7.27-7.09 (m, 6H), 6.94 (d, 2H), 4.12 (m, IH), 3.34 (m, 4H), 3.20 (d, 2H), 2.95 (m, 2H), 2.69 (s, 3H), 2.68 (s, 3H), 1.78 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 12H). Example 125 4-((4-amino- 1 -((phenylthio)methyl)butyPamino)-N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl) carbonyP- 3-nitrobenzenesulfonamide A mixture of Example 384E (53 mg), triphenylphosphine (131 mg), and water (50 mg) in THF (3 mL) was heated to 60 °C for 24 hours, cooled to room temperature, treated with IM hthium hydroxide (2 mL), and stirred for 48 hours. The mixture was treated with 4M HCl (1 mL) and silica gel (2.0 g) and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 10-30% methanol/dichloromethane to provide the desired product. MS (ESI(-)) m/e 607 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.57 (d, IH), 8.31 (d, IH), 7.98 (d, 2H), 7.91 (dd, IH), 7.70 (m, 4H), 7.57 (m, 3H), 7.32 (m, 2H), 7.23 (dd, 2H), 7.13 (m, 4H), 4.20 (m, IH), 3.37 (m, 2H), 2.78 (m, 2H), 1.81(m, 2H), 1.60 (m, 2H). Example 126 (3R)-3-((4-((((2'-methoxy-4'-(3-(neopentylamino)-3-oxopropyP- 1 , 1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide Example 126A 4'-(3-tert-butoxy-3-oxopropyl)-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylic acid A mixture of Example 122K (3.5 g), and potassium trimethylsilanolate (1.70 g) in THF (250 mL) at room temperature was stirred for 18 hours, dUuted with ethyl acetate (400 mL) and water (50 mL), and adjusted to pH 3 with 2N HCl. The organic phase was washed with water (150 mL) and brine (100 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (DCI (+)) m/e 357 (M+H) + . Example 126B tert-butyl 3-(4'-((((4-(((lR)-3-(dimethylamino)-3-oxo-l-((phenylthio methyl)propyl)amino)- 3-nitrophenyl)sulfonyl)amino)carbonyl)-2-methoxy-l,r-biphenyl-4-yl)propanoate A solution of Example 122F (2.7g, 6.15 mmol), Example 126A (3.2 g, 9.2 mmol), EDCI (2.349 g, 12.3 mmol), and DMAP (3.752g, 30.75 mmol) in DMF ( 30 mL) and dichloroethane (30 mL) at room temperature was stirred for 16 hours, diluted with ethyl acetate, washed with water and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI (-)) m/e 775 (M-H) " . Example 126C 3-(4'-((((4-(((lR)-3-(dimethylamino)-3-oxo-l-((phenylthio)methyl)propyl)amino)-3- nitrophenyPsulfonyl)amino)carbonyl)-2-methoxy- 1.1 '-biphenyl-4-yPpropanoic acid A mixture of Example 126B in TFA (20 mL) and dichloromethane (20 mL) at room temperature was stirred for 1 hour and concentrated to provide the desired product. MS (ESI (+)) m/e 721 (M+H) + . Example 126D (3R)-3-((4-((((2'-methoxy-4'-(3-(neopentylamino)-3-oxopropyl)-l .1 '-biphenyl-4- yPcarbonvPamino)sulfonyP-2-nitrophenvPamino)-N,N-dimethyl-4-(phenylthio)butanamide A solution of Example 126C (50 mg, 0.069 mmol), neopentylamine (21 mg, 0.20 mmol), EDCI (20 mg, 0.104 mmol), and HOBT (15 mg, 0.104 mmol) inN,N- dimethylacetamide (1 mL) and dichloroethane (0.5 mL) at room temperature was stirred for 16 hours. The mixture was concentrated, dissolved in 1: 1 DMSO/methanol (1.0 mL) and purified by reverse phase preparative HPLC (using a C-18 column and a solvent system increasing in gradient from 20 to 95% acetonitrile/water containing 0.1% TFA) to provide the desired product. MS (ESI(-)) m/e 788 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.70(br t, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.90 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.42 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.00-2.70 (m, 8H), 0.80 (s, 9H). Example 127 . (3RV3-((4-((((4'-(3-hydroxypropyP-2'-methoxy- 1.1 '-biρhenyl-4- yPcarbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio butanamide Example 127A r3R 3-((4-rrrr4'-(3-((tert-butyl(dimethvPsilyPoxy propyl)-2'-methoxy- 1.1 '-bipherιyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4- phenylthio butanamide The desired product was prepared by substituting Example 45 IB for Example 126A in Example 126B. MS (ESI(-)) m/e 803 (M-H) " . Example 127B (3RV3-f (4-((f (4'-f 3-hvdroxypropyP-2'-methoxy- 1.1 '-biphenyl-4- yPcarbonyPammo)sulfonyl)-2-nitrophenyl)amino)-N.N-mmethyl-4-(phenylthio)butanamide The desired product was prepared by substituting Example 127A for Example 126B in Example 126C. The mixture was concentrated, dissolved in 1 : 1 DMSO/methanol (1 mL) and purified by reverse phase preparative HPLC (using a C-l 8 column and a solvent system increasing in gradient from 20-95% acetonitrUe/water containing 0.1% TFA). MS (ESI(-)) m/e 691 (M-H) ' ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (m, 4H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 2H), 2.65 (t, 2H), 1.75 (m, 2H). Example 128 (3R -3-((4-((((2'-methoxy-4'-(3-oxo-3-pyrroHdin- 1 -ylpropyP- 1.1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N.N-dimethyl-4-(phenylthio)but-m--mide The desired product was prepared by substituting pyrroHdine for neopentylamine in Example 126. MS (ESI(-)) m/e 772 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.02 (d, IH), 6.92 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.42 (t, 2H), 3.28 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.00-2.70 (m, 6H), 2.60 (t, 2H), 1.80 (m, 4H). Example 129 3R -3-((4-((((2'-methoxy-4'-(3-oxo-3-(propylamino propyP-l .1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting propylamine hydrochloride for neopentylamine in Example 126 and adding N,N-diisopropylethylamine (0.1 mL) to the reaction mixture of Example 126D. MS (ESI(-)) m/e 760 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.81 (brt, IH) 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.90 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.42 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.00-2.70 (m, 6H), 2.40 (t, 2H), 1.48 (m, 2H), 0.80 (t, 3H). ' Example 130 (3R -3-((4-((((2'-methoxy-4'-(3-oxo-3-piperidin-l-ylpropyP-l.l'-biρhenyl-4- yl)carbonyPamino)sulfonyl)-2-nitrophenyPamino)-N,N-dimethyl-4-(phenyltMo butanamide The desired product was prepared by substituting piperidine for neopentylamine in Example 126. MS (ESI(-)) m/e 786 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.02 (d, IH), 6.92 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.42 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.00-2.70 (m, 6H), 2.60 (t, 2H), 2.50 (t, 2H), 1.60 (m, 2H), 1.48 (m, 4H). Example 131 isobutyl 4-(4-((((4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyl)propyl)amino)-3- nitrophenyPsulfonyPamino)carbonyPphenyPpiperazine-l-carboxylate Example 131 A isobutyl piperazine-1-carboxylate A solution of piperazine (8.61 g, 0.1 mol) in IM HCl (200 mL) at room temperature was treated with isobutyl chloroformate (13.66 g, 13 mL, 0.1 mol), adjusted to pH 3 with IM NaOH over 1 to 2 hours, stirred for 18 hours, quenched with 4M KOH, and extracted with dichloromethane (2 x 100 mL). The combined extracts were dried (MgSO 4 ), filtered, and concentrated to provide 10.9 g (59%) the desired product. MS (ESI(+)) m/e 187 (M+H) + . Example 13 IB isobutyl 4-(4-(ethoxycarbonyPphenyppiperazine- 1 -carboxylate The mixture of ethyl 4-fluorobenzoate (4.88 g, 29 mmol, 4.3 mL), Example 131A (5.4 g, 29 mmol), and potassium carbonate (4.007 g, 29 mmol) in NMP (10 mL) was heated to 140 °C for 18 hours, poured into water, and filtered. The filter cake was washed with water and hexanes and dried under vacuum at 50 °C to provide 2.8 g (29 %) of the desired product. MS (ESI(+)) m/e 335 (M+H) + . Example 13 IC 4-(4-(isobutoxycarbony piperazin- 1 -ypbenzoic acid A solution of Example 13 IB (2.8 g, 8.37 mmol) and 4M aqueous NaOH (10 mL) in 1: 1 THF/methanol (40 mL) was heated to reflux for 18 hours, and concentrated. The concentrate was dUuted with water and adjusted to pH 1 with concentrated HCl, treated with isobutyl chloroformate (3 mL), slowly adjusted to pH 12 with NaOH, and adjusted to pH 2 with HCl. The mixture was filtered and the filter cake was dried under vacuum to provide the desired product. MS (ESI(-)) m/e 305 (M-H) " . Example 13 ID isobutyl 4-(4-((((4-(((lR)-3-(dimethylamino)-l-((ρhenylthio)methvPpropyl)amino)-3- nitrophenyl)sulfonyPamino)carbonyl)phenyPpiperazine-l-carboxylate The desired product was prepared by substituting Example 13 IC and Example 122G for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 711 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.46 (d, IH), 8.23 (d, IH), 7.81 (dd, IH), 7.75 (d, 2H), 7.34-7.30 (m, 2H), 7.28-7.21 (m, 2H), 7.19-7.12 (m, IH), 6.89 (d, IH), 6.84 (d, 2H), 4.11- 4.01 (m, IH), 3.81 (d, 2H), 3.54-3.46 (m, 4H), 3.33 (d, 2H), 3.21-3.17 (m, 4H), 2.85-2.75 (m, 2H), 2.52 (s, 6H), 2.09-1.96 (m, 2H), 1.88 (hept, IH), 0.90 (d, 6H). Example 132 <3R)-3-( ' (4-((((2'-methoxy-4'-(3-oxo-3-rr2.2.2-trifluoroethvPamino)propyP-l .1 '-biphenyl-4- yPcarbonyl)amino)sulfonyl)-2-nitrophenyPamino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting trifluoroethylamine hydrochloride for neopentylamine in Example 126 and also adding N,N-diisopropylethylamine (0.1 mL) to the reaction mixture in Example 126D. MS (ESI(-)) m/e 800 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.89 (br d, IH), 8.57 (d, IH), 8.52 (brt, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.90 (dd, IH), 4.45 (m, IH), 3.90 (m, 2H), 3.75 (s, 3H), 3.42 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.00-2.70 (m, 4H), 2.60 (t, 2H). Example 133 methyl N-(4-((((4'-(3-hydroxypropyP-2'-methoxy- 1 , 1 '-biphenyl-4- ypcarbonvPamino sulfonyp-2-nitrophenyp-S-phenyl-L-cystemate Example 133A methyl N-(tert-butoxycarbonyl)-S-phenyl-L-cysteinate A 0 °C solution of N-(tert-butoxycarbonyl)-L-serine methyl ester (30 g, 137 mmol) and diisopropylamine (58 mL, 330 mmol) in dichloromethane (250 mL) was treated with methanesulfonyl chloride (11.65 mL, 151 mmol), stirred for 20 minutes, treated with thiophenol (15.5 mL, 151 mmol), warmed to room temperature, stirred for 30 minutes, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 310 (M-H) " . Example 133B methyl S-phenyl-L-cvsteinate A mixture of Example 133 A in 1 : 1 dioxane/4M HCl at room temperature was stirred for 3 hours, poured into saturated Na 2 CO 3 (400 mL), and extracted with ethyl acetate (3x 300 mL). The combined extracts were dried (TS SO-j), filtered, and concentrated to provide the desired product. Example 133C methyl N-(4-(aminosulfonyl)-2-nitrophenyl)-S-phenyl-L-cysteinate The desired product was prepared by substituting Example 133B and Example 122C for 2,2-dimethylcyclopentylamine and Example ID, respectively, in Example IE. MS (ESI(- )) m/e 410 (M-H) " . Example 133D methyl N-(4-((((4'-(3-hvdroxypropyl)-2'-methoxy- 1 , 1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)-S-phenyl-L-cysteinate The desired product was prepared by substituting Example 133C and Example 451B for Example IC and Example IB, respectively, in Example ID. The crude product was dissolved in TFA (5 mL), heated to 50 °C for 2 hours, and concentrated. The concentrate was purified by flash column chromatography on silica gel with ethyl acetate to provide the desired product. H NMR (300 MHz, DMSO-d 6 ) δ 1.76 (tt, 2H), 2.65 (t, 2H), 3.43 (t, 2H), 3.62 (s, 3H), 3.62 (m, IH), 3.72 (m, IH), 3.76 (s, 3H), 5.14 (m, IH), 6.88 (d, IH), 6.96 (s, IH), 7.10 (dd, 2H), 7.22 (d, IH), 7.26 (dd, 2H), 7.58 (dd, 2H), 7.88 (dd, 2H), 7.93 (dd, IH), 8.58 (d, IH), 8.88 (d, IH). MS (ESI(-)) m/e 678 (M-H) " . Example 134 N-(4-(8-azaspiro(4.5 dec-8-ypbenzoyp-4-(((lR)-2-(dimethylamino)-l- ((phenylthio)methyl)ethypamino)-3-nitrobenzenesulfonamide Example 134A tert-butyl ( 1 R)- 1 -formyl-2-(phenylthio)ethylcarbamate A solution of Example 133 A (8.1 g, 26.0 mmol) in dichloromethane at -78 °C was treated with IM DIBAL-H in dichloromethane (52 mL, 52 mmol), stirred for 3 hours, quenched with methanol (20 mL), and poured into saturated NaH 2 PO 4 . The mixture was extracted with ethyl acetate (3x 300 mL), and the combined extracts were dried (Na 2 SO 4 ), filtered, concentrated, and purified by flash column chromatography on sUica gel with 30% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 280 (M-H) " . Example 134B tert-butyl ( 1 R)-2-(dimethylamino - 1 -((phenylthio)methyl) ethylcarbamate A solution of Example 134A (1.25 g, 4.44 mmol), 2M dimethylamine in THF (2.7 mL, 5.4 mmol), and NaBH(OAc) 3 (1.32 g, 6.22 mmol) in dichloromethane at room temperature was stirred for 18 hours, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10% ethyl acetate/hexanes to provide the desired product. MS (ESI(+)) m/e 311 (M+H) + . Example 134C (2R)-N ,N -dimethyl-3-(phenylthio)propane-1.2-diamine The desired product was prepared by substituting Example 134B for Example 133 A in Example 133B. Example 134D 4-(((lR)-2-(dimethylamino)-l-((phenylthio)methyl)ethyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 134C and Example 122C for 2,2-dimethylcyclopentylamine and Example ID, respectively, in Example IE. MS (ESI(- )) m/e 409 (M-H) " . Example 134E N-(4-(8-azaspiro(4.5 dec-8-yPbenzovP-4-((( lRV2-f dimethylamino - 1 - ((phenylthio)methvPethyPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 134D and Example 257C for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 650 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 1.41 (m, 4H), 1.48 ,(m, 4H), 1.59(m, 4H), 2.31 (s, 6H), 2.63 (br s, 2H), 3.20 (m, 4H), 3.28 (dd, IH), 3.35 (dd, IH), 4.13 (m, IH), 6.81 (d, 2H), 6.95 (d, IH), 7.13 (dd, IH), 7.21 (dd, 2H), 7.31 (d, 2H), 7.72 (d, 2H), 7.82 (dd, IH), 8.35 (d, IH), 8.43 (s, IH). Example 135 (3R)-3-((4-((((2'-methoxy-4'-(3-oxo-3-((tetrahydrofur- -3-ylmethyl)amino)propyl)-l, - biphenyl-4-yl)carbonyl)amino)sulfonyl)-2-nitrophenyPamino)-N,N-dimethyl-4- (phenylthio)butanamide The desired product was prepared by substituting l-tettahydrofuran-3-ylmethanamine for neopentylamine in Example 126. MS (ESI(-)) m/e 802 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 12.5 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.92 (brt, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.70-3.60(m, 4H), 3.42 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.40 (t, 2H), 2.35(m, IH), 1.85 (m, IH), 1.5 (m, IH). Example 136 (3R)-3-((4-((((2'-methoxy-4'-(3-oxo-3-(pentylamino)propyP-l,l'-biphenyl-4- yl)c-irbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-ωmethyl-4-(phenyltMo)butanamide The desired product was prepared by substituting pentylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 788 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 12.5 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.80(brt, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.42 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H), 2.40 (t, 2H), 1.35(m, 2H), 1.25 (m, 4H), 0.85 (t, 3H). Example 137 (3R -3-((4-((((4'-(2-(dimethylamino -2-oxoethvP-2'-methoxy- 1 , 1 '-biphenyl-4- yl)carbonyl)amino)sulfonyP-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting Example 441 A and Example 122F for Example 5C and Example 3A, respectively, in Example 5D. The mixture was concentrated, dissolved in 1 : 1 DMSO/methanol (1.0 mL) and purified by reverse phase preparative HPLC with 20-95% acetonitrile/water containing 0.1 % TFA to provide the desired product. MS (ESI(-)) m/e 732 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (m, 5H), 3.45 (t, 2H), 3.05 (s, 3H), 2.90 (s, 3H), 2.85 (s, 3H), 2.79 (s, 3H), 3.10 (m, 2H). Example 138 (3R -3-((4-((((4'-(3-(4-acetylpiperazin- l-vP-3-oxopropyP-2'-methoxy- 1.1 '-biphenyl-4- yl)carbonyl)amino)sulfonvP-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butahamide The desired product was prepared by substituting 1-acetylpiperazine for neopentylamine in Example 126. MS (ESI(-)) m/e 829 (M-H) " ; 1H NMR (300 MHz, DMSO- de) δ 12.5 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.70-3.40 (m, 10H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H), 2.00 (s, 3H). Example 139 N-((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-ypbenzoyPamino)sulfonyP-2-nitrophenyl)amino)- 6-(phenylthio)hexyl)- 1 H-imidazole- 1 -carboxamide A solution of Example 287 (200 mg, 0.3 mmol) and l, -carbonyldiimidazole (60 mg, 0.33 mmol) in THF(10 mL) was heated to reflux for 5 hours. The mixture was concentrated and the concentrate was purified by flash column chromatography on silica gel with 1 : 1 dichloromethane/ethyl acetate to provide the desired product. MS (ESI) m/e 760 (M+H) ; H NMR (300 MHz, DMSO-de) δ 9.46 (m, IH), 8.48 (d, IH), 8.20 (m,lH), 7.87 (dd, IH), 7.73 (d, 2H), 7.62 (s, IH), 7.28-6.98 (m, 7H), 6.94 (d, 2H), 4.12 (m, IH), 3.30-3.10 (m, 7H), 1.75 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 12H). Example 140 (3R)-3-((4-((((2'-methoxy-4'-(3-oxo-3-((tett- ydrofuran-2-ylmemyPamino)propyl)- 1,1'- biphenyl-4-yPc-ιrbonyPamino)sulfonyl)-2-nitrophenyPamino)-N,N-dimethyl-4- (phenylthio)butanamide The desired product was prepared by substituting l-tetrahydrofuran-2-ylmethanamine for neopentylamine in Example 126. MS (ESI(-)) m/e 802 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 12.3 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7,92 (br t, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.70-3.40 (m, 3H), 3.45 (t, 2H), 3.10 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.48 (t, 2H), 1.75 (m, 3H), 1.45 (m, IH). Example 141 (3RV3-((4-f (((4'-(3-amino-3-oxopropylV2'-methoxy- 1.1 '-biphenyl-4- ypcarbonvPamino)sulfonyP-2-nitiOphenvPamino -N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting ammonium chloride for neopentylamine in Example 126 and adding N,N-diisopropylethylamine (0.1 mL) to the reaction mixture in Example 126D. MS (ESI(-)) m/e 718 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 12.4 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 6.80 (br s, 2H), 4.45 (m, IH), 3.75 (s, 3H), 3.40 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.42 (t,H). Example 142 (3R -3-((4-rr((4 , -(3-(cvclobutylamino -3-oxopropyP-2 , -methoxy- 1.1 '-biρhenyl-4- yl)carbonyPamino)sulfonyP-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting cyclobutylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 772 (M-H) " ; 1H NMR (300 MHz, DMSO- de) δ 12.4 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 8.05 (br d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 4.20 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.45 (t, 2H), 2.12 (m, 2H), 1.82 (m, 2H), 1.62 (m, 2H). Example 143 (3R -3-((4-r(((4'-(3-(tert-butylamino -3-oxopropyP-2'-methoxy-l.l'-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting tert-butylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 774 (M-H)-; 1H NMR (300 MHz, DMSO-d 6 ) δ 12.4 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.42 (br s, IH), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.45 (t, 2H), 1.25 (s, 9H). Example 144 (3R -3-r(4-((((2'-methoxy-4'-(;3-rmethylamino -3-oxopropyP-l .1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting methylamine hydrochloride for neopentylamine in Example 126 and adding N,N-diisopropylethylamine (0.1 mL) to the reaction mixture in Example 126D. MS (ESI(-)) m/e 732 (M-H)-; 1H NMR (300 MHz, DMSO-de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.78 (br q, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.52 (d, 3H), 2.45 (t, 2H). Example 145 (3R -3-((4-(((( " 2 , -methoxy-4'-(3-((2-(2-methoxyethoxy ethvPamino)-3-oxopropyl)- 1,1'- biphenyl-4-ypcarbonyPamino sulfonyl)-2-nitrophenyPamino -N,N-dimethyl-4- (phenylthio)butanamide The desired product was prepared by substituting 2-(2-methoxyethoxy)ethylamine hydrochloride for neopentylamine in Example 126 and adding N,N-dusopropylethylamine (0.1 mL) to the reaction mixture in Example 126D. MS (ESI(-)) m/e 820 (M-H) " ; ! H NMR (300 MHz, DMSO-de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.92 (brt, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.50-3.45 (m, 8H), 3.26 (s, 3H), 3.20 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.45 (t, 2H). Example 146 N- 4- 8-azaspiro(4.5 dec-8-vPbenzovP-4-((πR -2-morphoHn-4-yl-l- ((phenyltMo methyPethyl)amino)-3-nitrobenzenesulfonamide Example 146A tert-butyl (lR -2-morphoHn-4-yl-l-((phenylthio)methyl)ethylcarbamate The desired product was prepared by substituting morphohne for dimethylamine in Example 134B. MS (ESI(-)) m/e 351 (M-H) " . Example 146B (2R)-l-morphoHn-4-yl-3-(phenylthio)propan-2-amine The desired product was prepared by substituting Example 146A for Example 133A in Example 133B. Example 146C 4-(((lR)-2-morphoHn-4-yl-l-((phenyltMo)methyl)ethyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 146B and Example 122C for 2,2-dimethylcyclopentylamine and Example ID, respectively, in Example IE. MS (ESI(- )) m/e 451 (M-H) " . Example 146D N-(4-(8-azaspiro(4.5)dec-8-yl)benzoyl)-4-((( 1 R)-2-morphoHn-4-yl- 1 - ((phenyltl io)methyl)ethyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 146C and Example 257C for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 692 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 1.41 (m, 4H), 1.48 (m, 4H), 1.59(m, 4H), 2.38 (m, 2H), 2.42 (m, 2H), 2.61 (d, 2H), 3.25 (m, 4H), 3.28 (dd, IH), 3.42 (dd, IH), 3.51 (m, 4H), 4.18 (m, IH), 6.85 (d, 2H), 7.05 (d, IH), 7.11 (dd, IH), 7.19 (dd, 2H), 7.31 (d, 2H), 7.71 (d, 2H), 7.83 (dd, IH), 8.40 (d, IH), 8.48 (s, IH). Example 147 methyl N-(4-((((4'-(3-(dimethylamino)-3-oxopropyl)-2'-methoxy-l , 1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)-S-phenyl-L-cysteinate Example 147A 4'-(3-(dimethylamino)-3-oxopropyl)-2'-methoxy-l .1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 427A for Example 1 A in Example IB. Example 147B methyl N-(4-((((4'-(3-(dimethylamino)-3-oxopropyl)-2'-methoxy-l , 1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyP-S-phenyl-L-cysteinate The desired product was prepared by substituting Example 147A and Example 133C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 719 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 2.64 (t, 2H), 2.82 (t, 2H), 2.82 (s, 3H), 2.95 (s, 3H), 3.61 (s, 3H), 3.72 (m, IH), 3.75 (m, IH), 3.76 (s, 3H), 5.11 (m, IH), 6.90 (d, IH), 7.01 (s, IH), 7.11 (m, 2H), 7.21 (d, IH), 7.26 (dd, 2H), 7.53 (dd, 2H), 7.89 (dd, 2H), 7.93 (dd, IH), 8.55 (d, IH), 8.81 (d, IH). Example 148 N-(4-(8-azaspiro(4.5 dec-8-yPbenzoyl)-4-((( 1 R -2-(4-methylpiperazin- 1 -vP- 1 - ((phenylthio)methyl)ethyPamino)-3-nitrobenzenesulfonamide Example 148A tert-butyl ( 1 R)-2-(4-methylpiperazin- 1 -yl)- 1 -((phenylthio)methypethylcarbamate The desired product was prepared by substituting N-methylpiperazine for dimethylamine in Example 134B. MS (ESI(+)) m/e 366 (M+H) + . Example 148B (2R)- 1 -(4-methylpiperazin- 1 -yl)-3-(phenylthio)propan-2-amine The desired product was prepared by substituting Example 148A for Example 133A in Example 133B. Example 148C 4-((( 1 R -2-(4-methylpiperazin- 1 -yl)- 1 -((phenylthio methvPethyl)amino)-3 - nitrobenzenesulfonamide The desired product was prepared by substituting Example 148B and Example 122C for 2,2-dimethylcyclopentylamine and Example ID, respectively, in Example IE. MS (ESI(- )) m/e 464 (M-H) " . Example 148D N-(4-(8-azaspiro(4.5)dec-8-vDbenzovD-4-(Y( 1 R -2-(4-methylpiperazin- 1 -vP- 1 - ((phenylthio)methyl)ethyl)amino)-3-mtrobenzenesulfonamide The desired product was prepared by substituting Example 148C and Example 257C for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 705 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.42 (m, 4H), 1.49 (m, 4H), 1.59 (m, 4H), 2.42 (s, 3H), 3.20(m, 4H), 3.22-3.40 (m, 12H), 4.12 (m, IH), 6.80 (d, 2H), 6.95 (d, IH), 7.16 (dd, IH), 7.23 (dd, 2H), 7.31 (d, 2H), 7.71 (d, 2H), 7.81 (dd, IH), 8.30 (d, IH), 8.44 (s, IH). Example 149 4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyl)propyPamino)-N-((2'-methoxy-4'-(3-(4- methylpiperazin- 1 -yl)-3-oxopropyl)-l .1 '-biphenyl-4-yPcarbonyP-3-nitrobenzenesulfonamide Example 149A 2'-methoxy-4'-(3-(4-methylpiperazin-l-yl)-3-oxopropyl)-l,r-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 362 A for Example 1 A in Example IB. Example 149B 4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyl)propyl)amino)-N-((2'-methoxy-4'-(3-(4- methylpiper-izin-l-yP-3-oxopropyl)-l,r-biphenyl-4-yl)c-ιrbonyP-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 149A and Example 122G for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 787, 789 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.05 (m, 2H), 2.20 (s, 3H), 2.28 (t, 4H), 2.56 (s, 6H), 2.66 (t, 2H), 2.84 (t, 2H), 3.28 (d, 2H), 3.41 (m, 2H), 3.46 (t, 4H), 3.74 (s, 3H), 4.08 (m, IH), 6.89 (t, 2H), 6.98 (s, IH), 7.16 (d, IH), 7.18 (d, IH), 7.25 (t, 2H), 7.32 (d, 2H), 7.38 (d, 2H), 7.82 (dd, IH), 7.88 (d, 2H), 8.21 (d, IH), 8.48 (d, IH). Example 150 (3R -3-((4-((((4'-(3-azetidin-l-yl-3-oxopropyp-2'-methoxy-l,l'-biphenyl-4- yPcarbonypamino)sulfonvP-2-nitrophenyl)amino -N,N-dimethyl-4-(phenylthio butanamide The desired product was prepared by substituting azetidine hydrochloride for neopentylamine in Example 126 and adding N,N-diisopropylethylamine (0.1 mL) to the reaction mixture in Example 126D. MS (ESI(-)) m/e 758 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30- 7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 4.05 (t, 2H), 3.82 (t, 2H), 3.75 (s, 3H), 3.45 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.35 (t, 2H), 2.15 (m, 2H). Example 151 (3R)-3-((4-((((4'-( ' 3-(isopropylamino)-3-oxopropyl)-2'-methoxy- 1 , 1 '-biphenyl-4- yPcarbonyl)amino)sulfonyP-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting isopropylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 760 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.60 (br d, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.85 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.45 (t, 2H), 1.02 (d, 6H). Example 152 (3R)-3-((4-((((2'-methoxy-4'-(3-(methyl(propyPamino)-3-oxopropyl)-l,r-biphenyl-4- yl)carbonyl)anιino)sulfonyP-2-nitrophenyl)amino)-N.N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting N-methyl-N-propylamine for neopentylamine in Example 126. MS (ESI(-)) m e 774 (M-H) + ; H NMR (300 MHz, DMSO-de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30- 7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 3.25 (t, 2H), 2.95 (s, 3H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.65 (t, 2H), 1.50 (m, 9H), 0.85 (t, 3H). Example 153 (3R -3-(T4-((T C4'-( ' 3-( ' (2-(dimethylamino ethvPamino -3-oxopropyP-2'-methoxy- 1.1'- biphenyl-4-vPcarbonyl)amino sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4- (phenylthio)butanamide The desired product was prepared by substituting N,N-dimethylethylenediamine for neopentylamine in Example 126. MS (ESI(-)) m/e 789 (M-H) " ; 1H NMR (300 MHz, DMSO- de) δ 9.25 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 8.12 (br t, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (m, 6H), 3.15 (t, 2H), 2.95 (s, 3H), 2.80 (s, 3H), 2.79 (s, 6H), 3.10-2.70 (m, 4H). Example 154 (3R)-3-((4-((((4'-(3-((2-(mmethylamino)ethyP(methvPamino -3-oxopropyP-2'-methoxy-l,r- biphenyl-4-yPcarbonyl)amino)sulfonyp-2-nitrophenvPamino)-N,N-dimethyl-4- (phenylthio butanamide The desired product was prepared by substituting N,N,N'-trimethylethylenediamine for neopentylamine in Example 126. MS (ESI(-)) m/e 803 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 9.25 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.65 (m 4H), 3.45 (t, 2H), 3.15 (t, 2H), 2.95 (s, 3H), 2.90 (s, 3H), 2.82 (s, 6H), 2.79 (s, 3H), 3.10-2.70 (m, 4H). Example 155 (3R -3-((4-((((4'-(3-(tert-butyl(methvPamino -3-oxoproρyP-2'-methoxy-l .1 '-biphenyl-4- yl)carbonyl)amino sulfonyl)-2-nitrophenyl)amino -N.N-dimethyl-4-(phenyltl io)butanamide The desired product was prepared by substituting N-methyl-tert-butylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 788 (M-H) " ; H NMR (300 MHz, DMSO- d 6 ) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 2.95 (s, 3H), 2.85 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.60 (t, 2H), 1.35 (s, 9H). Example 156 isobutyl 4-(4-((((4-(((lR)-5-amino-l-((phenylthio)methyl)pentyl)amino -3- nitrophenyl)sulfonyl)amino)carbonyl)phenyl)piperazine-l-carboxylate Example 156A isobutyl 4-(4-((((4-((( 1 R -5-((tert-butoxycarbonvP amino)- 1 - ((phenylthio methyl)pentyl)amino)-3- nitrophenyPsulfonyPamino)carbonyPphenyl)piperazine-l-carboxylate The desired product was prepared by substituting Example 131 C and Example 124C for Example IB and Example IC, respectively, in Example ID. Example 156B isobutyl 4-(4-((((4-((( 1 R)-5-amino- 1 -((phenylthio)methyl)pentyl)amino -3 - nitrophenyl)sulfonyl)amino)carbonyPphenyl)piperazine-l-carboxylate The desired product was prepared by substituting Example 156A for Example 120D in Example 120E. MS (ESI(-)) m/e 711 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 12.07 (br s, IH), 8.54 (d, IH), 8.32 (d, IH), 7.86 (dd, IH), 7.78 (d, 2H), 7.76 (br s, IH), 7.26-7.08 (m, 6H), 6.96 (d, IH), 4.12-4.01 (m, IH), 3.81 (d, 2H), 3.74-3.65 (m, 2H), 3.54-3.46 (m, 4H), 3.38-3.34 (m, 4H), 2.78-2.70 (m, 2H), 1.88 (hept, IH), 1.8-1.72 (m, 2H), 1.56-1.47 (m, 2H), 1.45-1.35 (m, 2H), 0.90 (d, 6H). Example 157 (3R -3-rr4-((((4'-(3-(diethylaminoV3-oxopropyP-2 , -methoxy- 1.1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting diethylamine hydrochloride for neopentylamine in Example 126 and adding N,N-diisopropylethylamine (0.1 mL) to the reaction mixture in Example 126D. MS (ESI(-)) m/e 774 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30- 7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 3.30 (m 4H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.60 (t, 2H), 1.05 (2t, 6H). Example 158 4-(((lR)-5-amino-l-((phenyltMo)methyl)pentyPamino)-N-(4-(6-azaspiro(2.5)oct-6- yl)benzoyl)-3-nitrobenzenesulfonamide Example 158A ethyl 4-(1.4-dioxa-8-azaspiro(4.5)dec-8-yl)benzoate A mixture of ethyl 4-fluorobenzoate (6.0 mL, 41 mmol), l,4-dioxa-8- azaspiro(4,5)decane (13.5 mL, 102 mmol), and K 2 CO 3 (5.7g, 41 mmol) inNMP (35 mL) was stirred at 150 °C for 4 hours, cooled to room temperature, treated with water (0.5 L) and filtered. The filter cake was washed with water and dried briefly. The crude product was triturated with hexane, filtered, and dried under vacuum to provide the desired product. MS (DCI) m/e 292 (M+H) + . Example 158B ethyl 4-(4-oxopiperidin- 1 -ypbenzoate A solution of Example 158A (6.31g, 21.7 mmol) and 30% aqueous acetic acid (100 mL) in THF (50 mL) was stirred at 95 °C for 6 hours, cooled to room temperature, concentrated, treated with water, and extracted with dichloromethane. The combined extracts were washed with water and brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (DCI) m/e 248 (M+H) + . Example 158C ethyl 4-(4-methylenepiperidin- 1 -ypbenzoate A 0 °C solution of methyltriphenylphosphonium bromide (500 mg, 1.4 mmol) in THF (1.5 mL) was treated dropwise with IM sodium hexamethyldisilazide in THF (1.4 mL), stirred for 15 minutes, and added dropwise to a 0 °C solution of Example 158B (0.25 g, 1.0 mmol) in THF (2.1 mL). After stirring for 15 minutes, the reaction was quenched with water and was extracted with ethyl acetate. The combined extracts were washed with brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 9: 1 hexanes/ethyl acetate to provide the desired product. MS (DCI) m/e 246 (M+H) + . Example 158D ethyl 4-(6-azaspiro(2.5)oct-6-yl)benzoate A mixture of methy 1-3 -nitro- 1-nitrosoguanidine (1.18 g, 8.1 mmol), 40% KOH (3.4 mL), and diethyl ether (12 mL) at 0 °C was stirred for 10 minutes. The organic phase was added slowly to a -25 °C solution of Example 158C and Pd(OAc) 2 (18 mg, 0.11 mmol) in THF (8.8 mL). The mixture was stirred for 1 hour at -20 °C and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 9: 1 hexanes/ethyl acetate to provide the desired product. MS (DCI) m/e 260 (M+H) . Example 158E 4-(6-azaspiro(2.5)oct-6-yl)benzoic acid The desired product was prepared by substituting Example 158D for Example 119B in Example 119C. MS (DCI) m/e 232 (M+H) + . Example 158F tert-butyl ι ' 5R)-5-((4-((( ' 4-(6-azaspiro(2.5)oct-6-yl)benzoyPammo)sulfonvP-2- nitrophenyl)amino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 158E and Example 124C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 736 (M-H) " Example 158G 4-(((lR)-5-amino-l-((phenylthio)methyPpentyl)amino)-N-(4-(6-azaspiro(2.5)oct-6- yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 158F for Example 120D in Example 120E. MS (ESI(+)) m/e 654 (M+H) + ; ! H NMR (300 MHz, DMSO-d 6 ) δ 12.0 (s, IH), 8.54 (d, IH), 8.32 (d, IH), 7.86 (dd, IH), 7.75 (d, 2H), 7.25-7.05 (m, 6H), 6.96 (d, 2H), 6.82 (d, 2H), 4.10 (m, IH), 3.50 (m, 4H), 3.90 (m, 6H), 3.43 (m, 4H), 3.36 (m, 2H), 2.72 (m, 2H), 1. 78 (m, 2H), 1.52 (m, 2H), 1.39 (m, 4H). Example 159 4-(((lR)-5-(dimethylamino)-l-((phenylthio)methyl)pentyPamino)-N-(4-(4,4- dimethylpiperidin- 1 -yl)benzoyl)-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 124E and Example 119C for Example IC and Example IB, respectively, in Example ID. MS(ESI(+)) m e 694 (M+H) + , 1H NMR (500 MHz, DMSO-d 6 ) δ 12.06 (s, IH), 10.57 (s, IH), 8.55 (d, IH), 8.31 (d, IH), 7.88 (dd, IH), 7.78 (d, 2H), 7.24 (m, 3H), 7.30 (m, 2H), 7.15 (t, 2H), 7.10 (d, IH), 7.05 (m, 2H), 4.13 (m, IH), 3.35 (d, 6H), 2.94 (m, 2H), 2.67 (d, 6H), 1.77 (m, 2H), 1.65 (m, 2H), 1.59 (m, 4H), 1.51 (m, 4H), 1.43 (m, 4H), 1.38 (m, 2H). Example 160 (3R -3-((4-((( " (2'-methoχy-4'-(3-((2-methoxyethyP(methvPamino)-3-oxopropyP-l,r- biphenyl-4-yPc-ιrbonyl)amino)sulfonyl)-2-nitrophenyPamino)-NN-dimethyl-4- (phenylthio)butanamide The desired product was prepared by substituting N-(2-methoxyethyl)methylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 790 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 12.45 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 4H), 3.25 (s, 3H), 2.90 (s, 3H), 2.85 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H), 2.60 (t, 2H). Example 161 (3R)-3-((4-((((4'-(3-((3-(dimethylamino)propyl)amino)-3-oxopropyl)-2'-methoxy-l,r- biphenyl-4-yl)c-ιrbonyl)amino)sulfonyl)-2-nitrophenyPamino)-N,N-dimethyl-4- (phenylthio)butanamide The desired product was prepared by substituting N,N-dimethylpropanediamine for neopentylamine in Example 126. MS (ESI(-)) m/e 803 (M-H) " ; 1H NMR (300 MHz, DMSO- de) δ 9.25 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 8.05 (br t, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (m 4H), 3.15 (t, 2H), 2.90 (s, 3H), 2.80 (s, 3H), 2.75 (2s, 6H), 3.10-2.70 (m, 4H), 2.45(m, 2H), 1.75 (m, 2H). Example 162 4-(((4-(aminomethypbicvclo(2.2.2 oct-l-vPmethypamino -N-(4-(8-azaspiro(4.5 dec-8- ypbenzo yl) -3 -nitrobenzenesulfonamide Example 162A tert-butyl (4-(((4-(aminosulfonyP-2-nitrophenyl)amino)methyl)bicyclo(2.2.2)oct- 1 - ypmethylcarbamate A suspension of l,4-diaminomethyl(2,2,2)bicyclooctane (1.04 g, 6.2 mmol), diisopropylethylamine (2 mL) and Example 122C (1.36 g, 6.2 mmol) in 1,2-dichloroethane (20 mL) was stirred for 3 days at 75 °C and concentrated. The concentrate was redissolved in methanol (30 mL), treated with dnsopropylethylamine (2 mL) and BOC 2 O (1.636 g), heated to 50 °C, filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 0-3% methanol/dichloromethane to provide the desired product. MS (ESI(-)) m/e 467 (M-H) " . Example 162B tert-butyl (4-(((4-(((4-(8-azaspiro(4.5)dec-8-yl)benzoyl)amino)sulfonyl)-2- nitrophenyPamino)methyPbicyclo(2.2.2)oct-l-yl)methylcarbamate The desired product was prepared by substituting Example 162A and Example 257C for Example IC and Example IB, respectively, in Example ID. Example 162C 4-(((4-(aminomethyl)bicyclo(2.2.2)oct-l-yl)methyl)amino)-N-(4-(8-azaspiro(4.5)dec-8- vPbenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 1 2B for Example 120D in Example 120E. MS (ESI(-)) m/e 608 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 11.97 (br s, IH), 8.63 (d, IH), 8.48 (t, IH), 7.93 (dd, IH), 7.71 (d, 2H), 7.70 (br s, 3H), 7.31 (d, IH), 6.92 (d, 2H), 3.74-3.64 (m, 2H), 3.36-3.31 (m, 4H), 3.23 (d, 2H), 2.56 (q, 2H), 1.62-1.57 (m, 4H), 1.52-1.40 (m, 16H). Example 163 >3R)-3-((4-( (4'-(3-(bis(2-methoxyethvPamino)-3-oxopropyP-2 , -methoxy-l .1 '-biphenyl-4- ypc-ιrbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting bis(2-methoxyethyl)amine for neopentylamine in Example 126. MS (ESI(-)) m/e 834 (M-H) " ; 1H NMR (300 MHz, DMSO- de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (m, 10H), 3.25 (s, 6H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H). Example 164 (3R)-3-((4-((((4'-(3-((3-(dimethylamino)propyl)(methypamino)-3-oxopropyl)-2'-methoxy- 1 , 1 '-biphenyl-4-yl)c-ιrbonvPamino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4- (phenylthio)butanamide The desired product was prepared by substituting N,N,N'-trimethylpropylenediamine for neopentylamine in Example 126. MS (ESI(-)) m/e 817 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 9.25 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (m 4H), 3.15 (t, 2H), 2.98 (s, 3H), 2.90 (s, 3H), 2.80 (s, 3H), 2.75 (2s, 6H), 3.10-2.70 (m, 4H), 2.45 (m, 2H), 1.75 (m, 2H). Example 165 4-(3-(2-methoxy-4'-((((3-nitro-4-((2- (phenyltMo)ethyPamino)phenyl)sulfonyl)amino)carbonyl)-l , 1 '-biphenyl-4- yppropyppiperazine- 1 -carboximidamide A solution Example 183D (200 mg, 0.29 mmol), lH-pyrazole-1-carboxamidine hydrochloride (42 mg, 0.29 mmol), and diisoopropylethylamine (0.101 mL, 0.58 mmol) in DMF was stirred at 45 °C for 24 hours. The mixture was purified by reverse-phase HPLC using 50% CH 3 CN/water to provide the desired product. MS (ESI(-)) m/e 730 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 2.12 (m, 2H), 2.70 (m, 2H), 3.10 (m, 2H), 3.30 (dd, 2H), 3.25-3.55 (m, 6H), 3.68 (m, 4H), 3.79 (s, 3H), 6.92 (d, IH), 7.04 (s, IH), 7.15 (s, 2H), 7.19 (dd, IH), 7.25 (d, 2H), 7.32 (m, 2H), 7.49 (s, IH), 7.58 (d, IH), 7.92 (dd, IH), 8.62 (d, IH), 8.80 (dd, IH). Example 166 N-f4-f l-butyl-2-oxo-2.3-dihvdro- 1 H-benzimidazol-5-vPbenzovP-4-( (Y 1 RV3- (dimethylamino)-l-((phenylthio)methyPpropyl)amino)-3-nitrobenzenesulfonamide Example 166A 4-bromo-N-butyl-2-mtroanUine A solution of butylamine (1.25 g, 17.1 mmol) in DMSO (14 mL) was treated with 4- bromo- l-fluoro-2-nitrobenzene (1.50 g, 6.82 mmol), heated to 70 °C for 1 hour, added to IM HCl (60 mL), and extracted with diethyl ether (3 x 75 mL). The combined extracts were washed with brine (20 mL), dried (Na 2 SO 4 ), filtered, and concentrated to provide the desired product. Example 166B 4-bromo-N -butylbenzene-l,2-diamine A mixture of Example 166A (1.82 g, 6.66 mmol) and tin(II) chloride dihydrate (3.76 g, 16.6 mmol), and concentrated HCl (22 mL) in isopropanol (30 mL) at room temperature was stirred for 90 minutes, adjusted to pH 6.5-7.5 using NaHCO 3 and 6M NaOH, and filtered. The filter cake was washed with water and ethyl acetate, and the filtrate was separated. The aqueous phase was extracted with ethyl acetate (3 x 50 mL) and the combined organic phases were washed with brine (20 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 20-50% ethyl acetate/hexanes to provide the desired product. Example 166C 5-bromo-l-butyl-1.3-dihydro-2H-benzimidazol-2-one A mixture of Example 166B (1:36 g, 5.59 mmol) and triphosgene (582 mg, 1.96 mmol) in dioxane was heated to reflux for 16 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with 30% ethyl acetate/hexanes to provide the desired product. Example 166D 4-( 1 -butyl-2-oxo-2,3-dihydro~ 1 H-benzimidazol-5-yPbenzoic acid The desired product was prepared by substituting Example 166C for 6-bromoindole in Example 4A. Example 166E N-(4-( 1 -butyl-2-oxo-2.3-dihydro- 1 H-benzimidazol-5-vPbenzovP-4-((Y 1 R)-3- (dimethylamino)-l-((phenylthio)methyPpropyPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 166D and Example 122G for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 715, 717 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ.0.91 (t, 3H), 1.30 (q, 2H), 1.63 (tt, 2H), 2.15 (m, 2H), 2.70 (s, 6H), 3.10 (m, 2H), 3.30 (d, 2H), 3.80 (t, 2H), 4.10 (m, IH), 6.89 (t, 2H), 6.95 (s, IH), 6.98 (d, IH), 7.15-7.25 (m, 3H), 7.26-7.36 (m, 3H), 7.56 (d, 2H), 7.85 (dd, IH), 7.94 (d, 2H), 8.13 (d, IH), 8.20 (d, IH), 8.48 (d, IH), 10.91 (s, IH). Example 167 isobutyl 4-(4-((((4-(((lR -3-morphoHn-4-yl-l-((phenylthio methyPpropyl)amino -3- nitrophenypsulfonvpamino)carbonypphenvppiperazine-l-carboxylate The desired product was prepared by substituting Example 13 IC and Example 463 A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 753 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.51 (d, IH), 8.37 (d, IH), 7.81 (dd, IH), 7.76 (d, 2H), 7.32-7.11 (m, 5H), 7.06 (d, IH), 6.91 (d, 2H), 4.20-4.08 (m, IH), 3.81 (d, 2H), 3.56-3.46 (m, 8H), 3.36 (d, 4H), 3.35-3.26 (m, 4H), 2.57-2.45 (m, 2H), 2.09-1.97 (m, 2H), 1.88 (heptet, IH), 0.90 (d, 6H). Example 168 4-(3-(2-methoxy-4'-((((3-nitro-4-((2- (phenylthio)ethyl)amino)phenyl)sulfonyl)amino)carbonyl)-l .1 '-biphenyl-4- vPpropyPpiperazine- 1 -carboxamide A solution of Example 183D and trimethylsilyl isocyanate in THF at room temperature was stirred for 24 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10/10/80 methanol/acetonitrUe/ethyl acetate to provide the desired product. MS (ESI(-)) m/e 731 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.79 (m, 2H), 2.31 (br s, 6H), 2.51 (dd, 2H), 3.28 (m, 4H), 3.32 (s, 3H), 3.60 (m, 2H), 3.73 (s, 3H), 5.91 (s, 2H), 6.85 (d, IH), 6.92 (s, IH), 6.97 (d, IH), 7.18 (d, IH), 7.20 (d, IH), 7.31 (dd, 2H), 7.39 (m, 3H), 7.88 (d, 2H), 8.50 (s, IH). Example 169 N-(4-(2-azaspiro(4.4)non-2-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 120C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 579 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 11.87 (s, IH), 8.76 (t, IH), 8.60 (d, IH), 8.32 (d, IH), 7.91 (dd, IH), 7.72 (d, 2H), 7.37 (dd, 2H), 7.26 (t, 2H), 7.17 (m, 2H), 6.50 (d, IH), 3.65 (m, 2H), 3.25-3.38 (m, 4H), 3.17 (s, 2H), 1.85 (t, 2H), 1.65 (m, 4H), 1.55 (m, 4H). Example 170 3-nitro-N-(4-(l-(3-phenylpropyl)-lH-benzimidazol-5-yl)benzoyl)-4-((2- (phenylthio ethyPamino)benzenesulfonamide Example 170A 4-bromo-N -(3 -phenylpropypbenzene- 1 ,2-diamine The desired product was prepared by substituting 3-phenylpropylamine for butylamine in Examples 166A and 166B. Example 170B 5-bromo- 1 -(3-phenylpropyP- 1 H-benzimidazole A solution of Example 170A (560 mg, 1.83 mmol) in trimethyl orthoformate (10 mL) at 95 °C was stirred for 16 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50-100% ethyl acetate/hexanes to provide the desired product. Example 170C 4-( 1 -(3 -phenylpropyl)- 1 H-benzimidazol-5-yPbenzoic acid The desired product was prepared by substituting Example 170B for 6-bromoindole in Example 4A. Example 170D 3-nitro-N-(4-(l-(3-phenylpropyl)-lH-benzimidazol-5-yl)benzoyl)-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 170C and Example 77B for Example IB and Example IC, respectively, in Example ID. H NMR (300 MHz, DMSO-de) δ 2.51 (tt, 2H), 2.61 (tt, 2H), 3.28 (t, 2H), 3.61 (dt, 2H), 4.30 (t, 2H), 7.00 (d, IH), 7.15-7.35 (m, 9H), 7.40 (dt, 2H), 7.59 (dd, IH), 7.69 (dd, 2H), 7.89 (dd, IH), 7.97 (m, 3H), 8.28 (s, IH), 8.52 (d, IH), 8.52 (t, IH). Example 171 tert-butyl (5R)-5-((4-(((4-(4-ethyl-4-methylpiperidin- 1 -yl)benzoyl)amino)sulfonyl)-2- nitrophenyl)amino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 123C and Example 124C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 752 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.95 (s, IH), 8.54 (d, IH), 8.31 (d, IH), 7.84 (dd, IH), 7.74 (d, 2H), 7.25-7.08 (m, 6H), 6.92 (d, 2H), 6.72 (t, IH), 4.08 (s, IH), 3.46 (t, IH), 3.44 (t, IH), 3.24-3.14 (m, 2H), 2.87 (m, 2H), 1.73 (m, 2H), 1.31 (s, 9H),1.40-1.22 (m, 10H), 0.90 (s, 3H), 0.80 (t, 3H). Example 172 (3R)-3-((4-((((2'-methoxy-4'-(3-((3-methoxypropyl)amino -3-oxopropyP-l , 1 '-biphenyl-4- vPcarbonypamino sulfonyp-2-nittophenyl)amino -N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting 3-methoxypropylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 790 (M-H) " ; H NMR (300 MHz, DMSO- de) δ 12.45 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.82 (br t, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 3.25 (t, 2H), 3.18 (s, 3H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H), 2.45 (t, 2H), 1.60 (m, 2H). Example 173 tert-butyl 1 -benzyl-2-(4-(4-(;((;(3-nitro-4-((2- (phenyltMo)ethyPamino)phenyl)sulfonyl)amino)carbonyl)phenyPpiperazin-l- yl) ethylcarbamate Example 173 A 3-nitro-4-((2-(phenyltMo)ethyPamino)-N-(4-piperazin-l-ylbenzoyPbenzenesulfonamide The desired product was prepared by substituting Example 405 for Example 120D in Example 120E. MS (ESI(-)) m/e 540 (M-H) " . Example 173B tert-butyl 1 -benzyl-2-(4-(4-((((3-nitro-4-((2- phenylthio)ethyl)amino)phenyl)sulfonyl)amino)carbonyPphenyl)piperazin-l- yl) ethylcarbamate A solution of Example 173 A (108 mg, 0.2 mmol) and (l-benzyl-2-oxo-ethyl)- carbamic acid tert-butyl ester (50 mg, 0.2 mmol) in 1:1 methanol/THF (8 mL) at room temperature was treated with IM sodium cyanoborohydride in THF (0.4 mL, 0.4 mmol), stirred for 18 hours, and concentrated. The concentrate was partitioned between ethyl acetate and saturated sodium bicarbonate, and the organic phase was dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 0-10% methanol/dichloromethane to provide the desired product. MS (ESI(-)) m/e 773 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.67 (t, IH), 8.55 (d, IH), 7.88 (dd, IH), 7.74 (d, 2H), 7.37 (d, 2H), 7.30-7.08 (m, 9H), 6.90 (d, 2H), 6.67 (br d, IH), 3.88-3.80 (m, IH), 3.64 (q, 2H), 3.31-3.20 (m, 10H), 2.81 (dd, IH), 2.62-2.50 (m, 3H), 1.30 (s, 9H). Example 174 (3R)-3-((4-((((4'-(3-fisobutylamino -3-oxopropyl)-2'-methoxy- 1.1 '-biphenyl-4- yl)carbonvPamino)sulfonvP-2-nitrophenyPamino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting isobutylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 774 (M-H) " ; ! H MR (300 MHz, DMSO-d 6 ) δ 12.45 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.80 (br t, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H), 2.45 (t, 2H), 1.65 (m, IH), 0.80(d, 6H). Example 175 N-((4 '-fluoro- 1.1 '-biphenyl-4-yl) carbonyP-4-((2-hydroxy- 1 - ((phenylthio)methyP ethyl) amino) -3 -nitrobenzenesulfonamide Example 175A methyl N-(tert-butoxycarbonyl)-S-phenylcysteinate The desired product was prepared by substituting DL-BOC-serine methyl ester for Example 27 A in Example 27B. Example 175B tert-butyl 2-hy droxy- 1 -((phenylthio)methy ethylc arbamate A solution of Example 175A (1.22 g, 3.91 mmol) in toluene (10 mL) at -78 °C was treated with IM DIBAL-H in toluene (8.6 mL), warmed to room temperature over 4 hours, dUuted with ethyl acetate (100 mL), washed sequentially with 0.1N HCl (30 mL), water (15 mL), and brine (50 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 30% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 284 (M+H) + . Example 175C 4-fluoro-N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyl)-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 122C for Example IC in Example ID. MS (ESI(-)) m/e 417 (M-H) " . Example 175D N-((4'-fluoro- 1 , 1 '-biphenyl-4-vP carbonyl)-4-((2-hydroxy- 1 - ((phenylthio)methvP ethyl) amino)-3 -nitrobenzenesulfonamide A mixture of Example 175B (100 mg, 0.35 mmol)) and 4M HCl in 1,4-dioxane (10 mL) was stirred at room temperature for 3 hours and concentrated. A mixture of the concentrate and Example 175C (160 mg, 0.38 mmol) was treated with DMF (2 mL) and N,N- diisopropylethylamine (0.5 mL), stirred for 18 hours, dUuted with ethyl acetate (60 mL), washed with IN HCl (20 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 30-100% ethyl acetate/dichloromethane to provide the desired product. MS (ESI(-)) m e 580 (M-H) " ; ! H NMR (400 MHz, DMSO-de) δ 8.50 (d, IH), 8.42 (d, IH), 7.95 (d, 2H), 7.70 (dd, IH), 7.73 (m, 2H), 7.60 (d, 2H), 7.40-7.19 (m, 8H), 3.95 (m, IH), 3.71 (m, IH), 3.62 (m, IH), 3.29 (m, 2H). Example 176 tert-butyl (5R)-5-((4-(((4-(6-azaspiro(2.5)oct-6-yl)benzoyl)amino)sulfonyl)-2- nitrophenyPamino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 158E and Example 124C for Example IB and Example IC, respectively, in Example ID. MS (ESI (-)) m/e 736; H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.54 (d, IH), 8.31 (d, IH), 7.84 (dd, IH), 7.74 (d, 2H), 7.08-7.25 (m, 6H), 6.95 (d, 2H), 6.72 (t, IH), 4.08 (s, IH), 3.43 ( , 4H), 3.30 (m, 4H), 2.87 (m, 2H), 1.37 (m, 4H), 1.31 (s, 9H), 1.25 (m, 2H), 0.33 (s, 4H). Example 177 N-(4-( 1 -butyl-2-oxo-2.3-dihvdro- lH-benzimidazol-5-yPbenzovP-4-((( 1 R -2-hvdroxy- 1 - ((phenylthio)methyl) ethyl) amino)-3 -nitrobenzenesulfonamide Example 177A N-((4-((riR)-2-(rtert-butyl(dmιethvPsUyPoxy)-l-((phenylsulfanyPmethvPethvPamino -3- nitrophenyl)sulfonyl)-4-(l-butyl-2-oxo-2,3-dihydro-lH-berιzimidazol-5-yl)benzamide The desired product was prepared by substituting Example 166D and Example 278 A for Example IB and Example IC, respectively, in Example ID. Example 177B N-(4-( 1 -butyl-2-oxo-2.3-dihydro- 1 H-benzimidazol-5-yPbenzovP-4-((( 1 R)-2-hydroxy- 1 - ((phenylthio)methyl) ethyl) amino) -3-nitrobenzenesulfonamide A mixture of Example 177A (40 mg, 0.05 mmol) and IM tetrabutylammonium fluoride in THF (130 uL, 0.13 mmol) in THF (3 mL) at room temperature was stirred for 3 hours, treated with IM HCl (10 mL), and extracted with 5% methanol in ethyl acetate (3 x 20 mL). The combined extracts were washed with brine (5 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 20% methanol/ethyl acetate to provide the desired product. MS (ESI) m/e 674, 676 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.91 (t, 3H), 1.30 (q, 2H), 1.59 (tt, 2H), 3.28 (t, 2H), 3.67 (m, IH), 3.80 (t, 2H), 3.92 (m, 2H), 5.21 (t, IH), 6.83 (d, IH), 7.21 (m, 3H), 7.29 (td, 2H), 7.38 (dd, 2H), 7.55 (d, 2H), 7.80 (dd, IH), 7.94 (d, 2H), 7.95 (d, IH), 8.41 (d, IH), 8.49 (d, IH), 10.90 (s, IH). Example 178 N-(2-(dimethylamino)ethyP-3-(4'-((((4-(((lR -3-(dimethylamino -l- ((phenyltMo)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)amino)carbonyP-2-methoxy-l.r- biphenyl-4-yP-N-methylpropanamide Example 178A methyl 4'-(3-((2-(dimethylamino)ethyl)(methyl)amino)-3-oxopropyl)-2'-methoxy- 1,1'- biphenyl-4-carboxylate The desired product was prepared by substituting N, N, N'-trimethylethylenediamine and Example 122L for Example IC and Example IB, respectively, in Example ID. MS (ESI(+)) m/e 399 (M+H) + . Example 178B 4'-(3-((2-(dimethylamino)ethyP(methyl)amino)-3-oxopropyP-2'-methoxy- 1 , 1 '-biphenyl-4- carboxylic acid The desrred product was prepared by substituting Example 178 A for Example 1A in Example IB. MS (ESI(-)) m/e 383 (M-H) " . Example 178C N-(2'-rdimethylamino)ethyP-3-(4'-((((4-(((lR -3-(dimethylamino)-l- ((phenyltMo)methyPpropyP-ιrijino)-3-nitrophenyl)sulfonyl)amino)carbonyP-2-methoxy biphenyl-4-yP-N-methylpropanamide The desired product was prepared by substituting Example 122G and Example 178B for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 789 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.32 (s, 2H), 2.50 (s, 12H), 2.62-2.89 (m, 10H), 2.96 (s, 3H), 3.05 (m, IH), 3.18 (d, IH), 3.51 (dd, IH), 3.73 (s, 3H), 4.08 (m, IH), 6.89 (m, 2H), 6.98 (d, IH), 7.18 (d, 2H), 7.26 (dd, 2H), 7.31 (dd, 2H), 7.38 (d, 2H), 7.81 (dd, IH), 7.89 (d, 2H), 8.26 (d, IH), 8.48 (d, IH). Example 179 N-r2-rdimethylamino ethvP-3-(4'-((((4-((πR -5-(dimethylamino)-l- ((phenyltMo)methypρentvPamino -3-nitrophenypsulfonyl)amino)carbonyP-2-methoχy- 1,1'- biphenyl-4-yl)-N-methylpropanamide The desired product was prepared by substituting Example 124E and Example 178B for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 817 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.99 (t, 2H), 1.18 (t, 2H), 1.55 (m, 2H), 1.78 (s, 3H), 1.90 (s, 3H), 2.22 (s, IH), 2.40 (s, 3H), 2.59 (s, 3H), 2.65 (m, 2H), 2.82 (s, 3H), 2.83 (m, IH), 2.96 (s, IH), 3.03 (m, 4H), 3.27 (m, IH), 3.33 (m, IH), 3.49 (dd, IH), 3.73 (s, 3H), 4.04 (m, IH), 6.89 (m, 2H), 6.98 (d, IH), 7.18 (d, 2H), 7.24 (dd, 2H), 7.31 (dd, 2H), 7.38 (d, 2H), 7.82 (dd, IH), 7.89 (d, 2H), 8.15 (d, IH), 8.48 (d, IH). Example 180 N~2~-(4-(((4-(4.4-dimethylcyclohexyPbenzoyl)amino)sulfonyl)-2-nitrophenyl)-N~l~.N~l~- bis(4-π " -(4-(((4-(4,4-dimethylcvclohexyl)benzoyl)amino)sulfonvP-2-nitrophenyl)-S- phenylcysteinyPmorphoUn-3-yl)-S-phenylcysteinamide Example 180A N-tert-butoxycarbonyl- 1 -morphoh ' n-4-yl- 1 -oxo-3-(phenylthio propan-2-amine A solution of Example 175A (600 mg, 1.92 mmol) and 2M aqueous Hthium hydroxide (4 mL) in methanol (10 mL) at room temperature was stirred for 5 hours and concentrated. The concentrate was treated with morphohne (263 mg, 3 mmol), EDCI (555 mg, 2.88 mmol), DMAP (20 mg ) and DMF (20 mL), stirred for 16 hours, dUuted with ethyl acetate (100 mL), washed sequentiaUy with water (50 mL), and brine (20 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(+)) m/e 367 (M+H) + . Example 180B 2 1 1 N -(4-(aminosulfonyl)-2-nitrophenyl)-N ,N -bis(4-(N-(4-(aminosulfonyl)-2-nitrophenyl)-S- phenylcysteinyPmorphoHn-3-yP-S-phenylcysteinamide The desired product was prepared by substituting Example 180A and Example 122C for Example 175B and Example 175C, respectively, in Example 175D. MS (ESI(+)) m/e 467 (M+H) + . Example 180C N~2 — (4-(((4-(4,4-dimethylcyclohexyPbenzoyl)amino)sulfonyl)-2-nitrophenyl)-N~l~,N~l — bis(4-(N-(4-(((4-(4,4-(Hmethylcyclohexyl)berjzoyl)arnino)sulfonyl)-2-nitrophenyl)-S- phenylcysteinyl)morphohn-3-yl)-S-phenylcysteinamide The desired product was prepared by substituting Example 77A and Example 180B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 679 (M-H) " ; 1H NMR (400 MHz, methanol-d-j) δ 8.98 (d, IH), 8.63 (d, IH), 7.92 (m, 3H), 7.27 (m, 2H), 7.20 (d, 2H), 7.09 (m, 3H), 6.92 (d, IH), 5.06 (m, IH), 3.67-3.50 (m, 4H), 3.42 (t, 2H), 2.43 (m, IH), 2.36 (t, 2H), 2.02 (m, 2H), 1.62 (m, 4H), 1.49 (m, 2H), 1.35 (m, 2H), 0.98 (s, 3H), 0.94 (s, 3H). Example 181 N-(4-(3-(cyclohexylmethyl)-2-oxo-2,3-dihydro-l,3-benzoxazol-6-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino benzenesulfonamide A mixture of Example 251D (80 mg, 0.14 mmol), 60% NaH in mineral oU (12 mg, 0.29 mmol), 15-crown-5 (64 mg, 0.29 mmol), and bromomethylcyclohexane (27 mg, 0.15 mmol) in DMF (5 mL) was heated to 95°C and stirred for 16 hours, treated with IM HCl (20 mL), and extracted with 5% methanol in ethyl acetate (3 x 20 mL). The combined extracts were washed with brine (5 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with ethyl acetate to provide the desired product. MS (ESI(-)) m/e 685 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.98-1.26 (m, 5H), 1.57-1.74 (m, 5H), 1.84 (m, IH), 3.28 (t, 2H), 3.62 (dt, 2H), 3.68 (d, 2H), 7.05 (d, IH), 7.19 (tt, IH), 7.29 (t, 2H), 7.39 (d, 3H), 7.58 (dd, IH), 7.68 (d, 2H), 7.72 (d, IH), 7.90 (dd, IH), 7.95 (d, 2H), 8.54 (d, IH), 8.59 (t, IH). Example 182 N-(4-( 1-benzyl- lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 182A N -benzyl-4-bromobenzene- 1 ,2-diamine The desired product was prepared by substituting benzylamine for 3- phenylpropylamine in Examples 166 A and 166B. Example 182B N-(4-(l-benzyl-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 182A for Example 170A in Examples 170B-170D. MS (ESI) m/e 662, 664 (M-H) " , (M+H) + ; ! H NMR (300 MHz, DMSO-de) δ 3.27 (t, 2H), 3.61 (dt, 2H), 5.52 (s, 2H), 6.99 (d, IH), 7.20 (tt, IH), 7.28-7.36 (m, 7H), 7.40 (dd, 2H), 7.52-7.67 (m, 5H), 7.88 (dd, IH), 7.95 (d, 2H), 8.45 (s, IH), 8.52 (d, IH), 8.52 (t, IH). Example 183 N-((2'-methoxy-4'-(3-piperazin-l-ylpropyP-l,r-biphenyl-4-yPcarbonyP-3-nitro-4-((2- (phenylthio)ethvPamino)benzenesulfonamide Example 183A. tert-butyl 4-(3-(2-methoxy-4'-(methoxycarbonyP- 1 , 1 '-biphenyl-4-yPpropanoyl)piperazine- 1 - carboxylate The desired product was prepared by substituting N-tert-butoxycarbonylpiperazine and Example 122L for Example IC and Example IB, respectively, in Example ID. MS (ESI(+)) m/e 483 (M+H) + . Example 183B tert-butyl 4-(3-(2-methoxy-4'-(methoxycarbonyP-l,l'-biphenyl-4-yPpropyl)piperazine-l- carboxylate The desired product was prepared by substituting Example 183 A for Example 122F in Example 122G. Example 183C 4'-(3-(4-(tert-butoxycarbonyl)piperazin-l-yl)propyP-2'-methoxy-l,r-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 183B for Example 1A in Example IB. MS (ESI(-)) m/e 453 (M-H) " . Example 183D N-((2'-methoxy-4'-(3-piperazin-l-ylpropyl)-l,r-biphenyl-4-yl)carbonyP-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 77B and Example 183C for Example IB and Example IC, respectively, in Example ID. The product was dissolved in TFA (5 mL) and stirred at room temperature for 90 minutes, concentrated, dissolved in toluene, and concentrated again to provide the desired product. MS (ESI(+)) m/e 690 (M+H) + ; X H NMR (300 MHz, DMSO-d 6 ) δ 1.99 (m, 2H), 2.69 (t, 2H), 3.10 ( , 2H), 3.30 (t, 4H), 3.49 (m, 6H), 3.68 (m, 2H), 3.77 (s, 3H), 6.91 (d, IH), 7.01 (s, IH), 7.20 (m, 2H), 7.25 (m, 3H), 7.39 (d, 2H), 7.58 (d, 2H), 7.90 (d, IH), 7.93 (dd, IH), 8.62 (d, IH), 8.81 (t, IH). Example 184 4-(((lR)-2-hvdroxy-l-((phenylthio methyPethvPamino -N-((4'-(3-hydroxypropyp-2'- methoxy-1 , 1 '-biphenyl-4-ypcarbonyP-3-nitrobenzenesulfonamide A solution of Example 133D (300 mg, 0.38 mmol) in THF (4 mL) at room temperature was treated with 2M L1BH 4 in THF (470 μL, 2.5 eq), stirred for 2 hours, quenched with a drop of water, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 100% ethyl acetate to provide the desired product. MS (ESI(-)) m/e 650 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.75 (m, 2H), 2.65 (t, 2H), 3.32 (m, 4H), 3.43 (t, 2H), 3.61 (dd, IH), 3.72 (dd, IH), 3.77 (s, 3H), 4.06 (m, IH), 6.88 (d, IH), 6.96 (s, IH), 7.11 ( , 2H), 7.22 (m, 2H), 7.31 (m, 2H), 7.59 (m, 2H), 7.88 (m, 3H), 8.10 (d, lH), 8.12 (d, IH). Example 185 tert-butyl (5R)-5-((4-(((4-(2-azaspiro(4.4)non-2-yl)benzoyl)amino)sulfonyl)-2- nitrophenvPamino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 120C and Example 124C for Example IB and Example IC, respectively, in Example ID. MS(ESI(-)) m/e 750 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 11.87 (s, IH), 8.53 (d, IH), 8.30 (d, IH), 7.84 (dd, IH), 7.74 (d, 2H), 7.25-7.08 (m, 6H), 6.72 (t, IH), 6.51 (d, 2H), 4.08 (s, IH), 3.17 (s, 2H), 2.87 (m, 2H), 1.85 (t, 2H), 1.73 (m, 2H), 1.63 (m, 4H), 1.55 (m, 4H), 1.32 (s, 9H), 1.35-1.22 (m, 8H). Example 186 N-((4'-(4-f4-methylphenvP-l ,3-oxazol-2-vP-l , 1 '-biphenyl-4-vPcarbonyP-3-nitro-4-( 2- (phenylthio) ethyl) amino)benzenesulfonamide Example 186A 4-(ethoxycarbonyl)phenylboronic acid A suspension of 4-(dihydroxyboryl)benzoic acid (5.0 g, 30.13 mmol) in ethanol (16.0 mL) was treated with 4N HCl in dioxane (34.0 mL), heated to reflux, stirred for 1.5 hours, and concentrated. The concentrate was partitioned between water (150.0 mL) and diethyl ether (100.0 mL) and the aqueous layer was extracted with diethyl ether (2 x 100 mL). The combined organic extracts were dried (MgSO 4 ), filtered, and concentrated to provide the ddeessiirreedd pprroodduucctt.. MMSS ((AAPPCCII)) mm//ee 119944 ((MM++HH)) '+ ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.07 (m, 2H), 7.81 (m, 2H), 4.41 (q, 2H), 1.41 (t, 3H). Example 186B 2-(4-bromophenyP-4-(4-methylphenvP-l,3-oxazole A mixture of 2-bromo-4'-methylacetophenone (152 mg, 0.7 mmol) and 4- bromobenzamide (200 mg, 1.0 mmol) was heated to 160 °C for 3 hours, cooled to room temperature, dissolved in ethyl acetate (20 mL), and treated with 5% sodium bicarbonate (20 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2 x 10 mL). The combined extracts were dried (MgSU 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 314, 316 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.70 (s, IH), 8.00-7.97 (m, 2H), 7.79-7.76 (m, 2H), 7.77-7.74 (m, 2H), 7.29-7.27 (m, 2H), 2.34 (s, 3H). Example 186C ethyl 4'-(4-(4-methylphenyl)- 1 ,3-oxazol-2-yl)- 1 , 1 '-biphenyl-4-carboxylate A solution of Example 186B (140 mg, 0.45 mmol) in ethylene glycol dimethyl ether (7.0 mL) at room temperature was treated with tetrakis(triphenylphosphine)palladium (26 mg, 0.02 mmol), stirred for 5 minutes, treated with a solution of Example 186A (104 mg, 0.54 mmol) in ethanol (1.5 mL), stirred for 5 minutes, treated with 2M sodium carbonate (1.1 mL, 2.23 mmol), heated to reflux, and stirred for 4 hours. The reaction mixture was cooled to room temperature and concentrated. The concentrate was dissolved in water (20 mL) and extracted with diethyl ether (4 x 20 mL). The combined extracts were dried (MgSO 4 ), fUtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 384 (M+H) + ; 1HNMR (300 MHz, DMSO-d 6 ) δ 8.71 (s, IH), 8.18-8.16 (m, 2H), 8.09-8.06 (m, 4H), 7.97-7.89 (m, 4H), 7.30-7.28 (m, 2H), 4.35 (q, 2H), 2.34 (s, 3H), 1.35 (t, 3H). Example 186D 4'-(4-(4-methylphenyl)-l ,3-oxazol-2-yl)- 1 , 1 '-biphenyl-4-carboxylic acid A solution of Example 186C (130 mg, 0.34 mmol) in THF (15.0 mL) and methanol (5.0 mL) at room temperature was treated with 2N sodium hydroxide (3.0 mL), stirred for 18 hours, concentrated, treated with water (2.0 mL), and adjusted to pH <7 with 2N HCl. The precipitate was filtered and dried under vacuum to provide the desired product. MS (DCI) m/e 356 (M+H) + ; X H NMR (300 MHz, DMSO-d 6 ) δ 8.72 (s, IH), 8.18-8.15 (m, 2H), 8.08- 8.04 (m, 4H), 7.97-7.86 (m, 4H), 7.31-7.28 (m, 2H), 2.35 (s, 3H). Example 186E N-r(4'-(4-(4-methylphenyP-l,3-oxazol-2-yP-l,l , -biphenyl-4-vPcarbonvP-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 186D and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (DCI) m/e 691 (M+H) + ; H NMR (300 MHz, DMSO-de) δ 12.51 (br s, IH), 8.79 (t, IH), 8.69 (s, IH), 8.65 (d, IH), 8.16-8.15 (m, 2H), 8.02-8.00 (m, 2H), 7.96-7.94 (m, 2H), 7.91-7.89 (m, 2H), 7.79-7.77 (m, 2H), 7.38-7.37 (m, 2H), 7.29-7.16 (m, 6H), 3.68 (q, 2H), 3.31 (q, 2H), 2.35 (s, 3H). Example 187 4-(((lR)-2-(dimethyl-ιmino)-l-((phenylthio)methyl)ethyl)amino)-N-((2'-methoxy-4'-(3- morphoHn-4-ylpropyl)-l , 1 '-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 134D and Example 1220 for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 746 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 1.78 (m, IH), 2.31 (dd, IH), 2.35 (m, 2H), 2.58 (d, IH), 2.62 (dd, IH), 3.00 (s, 6H), 3.48 (m, IH), 3.58 (m, 4H), 3.74 (s, 3H), 4.11 (m, IH), 6.84 (d, IH), 6.92 (d, IH), 6.95 (s, IH), 7.18 (dd, IH), 7.20 (dd, 2H), 7.30(s, IH), 7.33 (d, IH), 7.39 (d, 2H), 7.82 (dd, IH), 7.90 (d, 2H), 8.26 (d, IH), 8.48 (d, IH). Example 188 3R -3-((4-(ι ι(4'-(;3-(cvclopentylamino -3-oxopropyP-2'-methoxy- 1.1 '-biphenyl-4- yPcarbonyl)amino)sulfonyP-2-nitrophenyPamino)-N,N-dimethyl-4-(phenylthio butanamide The desired product was prepared by substituting cyclobutylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 786 (M-H) " ; 1H NMR (300 MHz, DMSO- de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.78 (br d, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 4.00(m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.45 (t, 2H), 1.78 (m, 2H), 1.60 (m, 2H), 1.50 (m, 2H), 1.35 (m, 2H). Example 189 methyl N-(4-((((2'-methoxy-4'-(3-morphoHn-4-yl-3-oxopropyl)-l,r-biphenyl-4- yPcarbonyl)amino sulfonyl)-2-nitrophenyl)-S-phenyl-L-cysteinate Example 189A 2'-methoxy-4'-(3-morpholin-4-yl-3-oxopropyl)-l , r-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 122M for Example 1A in Example IB. Example 189B . methyl N-(4-((((2'-methoxy-4'-(3-morphoHn-4-yl-3-oxopropyl)-l,r-biphenyl-4- ypcarbonvPamino)sulfonyP-2-nitrophenyp-S-phenyl-L-cysteinate The desired product was prepared by substituting Example 189A and Example 133C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 761 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.68 (t, 2H), 2.85 (t, 2H), 3.43 (m, 4H), 3.51 (m, 4H), 3.61 (s, 3H), 3.62 (dd, IH), 3.72 (dd, IH), 3.75 (s, IH), 3.78 (dd, IH), 6.91 (d, IH), 7.02 (s, IH), 7.11 (m, 2H), 7.21 (dd, 2H), 7.32 (m, 2H), 7.52 (d, 2H), 7.89 (d, 2H), 7.93 (dd, IH), 8.54 (d, IH), 8.82 (d, IH). Example 190 (3R -3-((4-((fr2'-methoxy-4'-(3-(r2-methoxyethvPamino)-3-oxopropyP-l,r-biphenyl-4- yPcarbonyPamino)sulfonyP-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting 2-methoxyethylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 776 (M-H) " ; 1H NMR (300 MHz, DMSO- de) δ 12.45 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.95 (br t, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.45 (t, 2H), 3.35 (t, 2H), 3.25 (s, 3H), 3.25 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H), 2.45 (t, 2H). Example 191 N-((4'-(2-((2-(dimethylamino)ethyP(methyPamino)ethyl)-2'-methoxy-l , 1 '-biphenyl-4- yl)carbonyP-4-(((lR)-2-(4-methylpiperazin-l-yl)-l-((phenyltMo)methyPethyl)amino)-3- nitrobenzenesulfonamide Example 191 A methyl 2'-methoxy-4'-(2-oxoethyl)- 1 , 1 '-biphenyl-4-carboxylate A solution of methoxymethyltriphenylphosphonium chloride (5.8 g, 16.9 mmol) in THF (80 mL) at room temperature was treated with IM LiHMDS in THF (16.9 mL, 16.9 mmol), stirred for 10 minutes, treated with Example 1221, (4.14 g, 15.3 mmol), stirred for 30 minutes, poured into brine, and extracted with ether three times. The combined extracts were washed with brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 15% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 283 (M-H) " . Example 19 IB methyl 4'-(2-((2-(dimethylamino)ethyl)(methyl)amino)ethyl)-2'-methoxy-l , 1 '-biphenyl-4- carboxylate The desired product was prepared by substituting N, N, N'-trimethylethylenediamine and Example 191 A for dimethylamine and Example 134A, respectively, in Example 134B. MS (ESI(+)) m/e 371 (M+H) + . Example 191C 4'-(2-((2-(dimethylamino)ethyp(methypamino)ethyp-2'-methoxy-l , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 191B for Example 1 A in Example IB. MS (ESI(+)) m/e 357 (M+H) + . Example 19 ID N-((4'-(2-((2-(dimethylamino ethyP(methyl)amino)ethyl)-2'-methoxy- 1 , 1 '-biphenyl-4- yl)carbonyP-4-((( 1 R -2-(4-methylpiperazin- 1 - l)- 1 -((phenylthio)methyl)ethyPamino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 148C and Example 191C for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 788 (M-H) " ; 1 HNMR (300 MHz, DMSO-d 6 ) δ 2.21 (s, 3H), 2.38 (s, 3H), 2.44 (s, 3H), 2.57 (s, 3H), 2.62 (m, 4H), 2.79 (m, 2H), 3.00 (m, 2H), 3.23 (t, 2H), 3.44 (m, lOH), 3.59 (dd, IH), 3. 75 (s, 3H), 3.77 (dd, IH), 4.11 (m, IH), 6.92 (d, IH), 6.96 (d, IH), 7.05 (s, IH), 7.15 (dd, IH), 7.24 (dd, 2H), 7.34 (m, 2H), 7.40 (d, 2H), 7.82 (dd, IH), 7.90 (dd, 2H), 8.31 (d, IH), 8.48 (d, IH). Example 192 (3R)-3-((4-((((4'-(3-((cyclopropylmethyl)amino)-3-oxopropyl)-2'-methoxy-l , 1 '-biphenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting aminomethylcyclopropane for neopentylamine in Example 126. MS (ESI(-)) m/e 758 (M-H) " ; H NMR (300 MHz, DMSO- de) δ 8.89 (br d, IH), 8.57 (d, IH), 7.99(br t, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.45 (t, 2H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H), 2.45 (t, 2H), 0.90 (m, IH), 0.38 (m, 2H), 0.20 (m, 2H). Example 193 (3R)-3-((4-((((4'-(3-(cyclopropylamino)-3-oxopropyl)-2'-methoxy-l , 1 '-biphenyl-4- yl)carbonyl)amino)sulfonyP-2-nitrophenyl)amino)-N,N-(Hmethyl-4-(phenyltbio)butanamide The desired product was prepared by substituting cyclopropylamine for neopentylamine in Example 126. MS (ESI(-)) m/e 758 (M-H) " ; H NMR (300 MHz, DMSO- de) δ 12.45 (br s, IH), 8.89 (br d, IH), 8.57 (d, IH), 7.90(brt, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 6H), 2.60 (M, lh), 2.45 (t, 2H), 0.60 (m, 2H), 0.38 (m, 2H). Example 194 4-(((lR)-5-amino-l-((phenylthio)methyl)pentyl)amino)-N-((2'-methoxy-4'-(3-morpholin-4- ylpropyp-l , 1 '-biphenyl-4-ypcarbonyl)-3-nitroberjzenesulfonamide A mixture of Example 122N (150 mg, 0.39 mmol ) and LiOH (25 mg, 0.58 mmol) in THF (3 mL), methanol (1 mL), and water (0.5 mL) was heated to 50 °C for 3 hours and concentrated. The concentrate was treated with a mixture of Example 124C (205 mg, 0.39 mmol), EDCI (150mg, 0.78 mmol), and DMAP (240 mg, 1.96mmol) in DMF ( 1.5 mL) and 1,2-dichloroethane (1.5 mL), stirred at room temperature for 16 hours, dUuted with ethyl acetate, washed with water and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 5% methanol/dichloromethane. The product was treated with 1 : 1 TFA: dichloromethane (2 mL), stirred for 30 minutes, and concentrated to provide the desired product. MS (ESI(-)) m/e 760 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 10.05 (br s, IH), 8.55 (d, IH), 8.35 (br d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.70 (br s, 2H), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.10 (m, IH), 3.75 (s, 3H), 3.45-3.35 (m, 8H), 3.15 (m, 4H), 2.75 (m, 2H), 2.70 (t, 2H), 2.00 (m, 2H), 1.75 (m, 2H), 1.50 (m, 2H), 1.40 (m, 2H). Example 195 4-((2,2-difluoro-2-(phenylthio ethyl)amino)-N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyl)-3- nitrobenzenesulfonamide Example 195A 2.2-difluoro-2-(phenylthio)ethanamine A mixture of 2,2-difluoro-2-phenylsulfanylacetamide (1 g, 4.92 mmol) in THF at room temperature was treated with BH 3 THF (IM, 25 mL), stirred for 18 hours, quenched with methanol (5 mL), and concentrated. The concentrate was treated with 2M HCl and heated to 80 °C for 30 minutes and concentrated. The concentrate was partitioned between dichloromethane and saturated sodium bicarbonate, and the organic phase was dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (ESI(+)) m/e 190 (M+H) + . Example 195B 4-((2,2-difluoro-2-(phenylthio)ethyl)amino)-3-nitrobenzenesulfonamide A suspension of Example 195A (0.26 g, 1.37 mmol), dnsopropylethylamine (0.5 mL), and Example 122C (0.3 g, 1.37 mmol) in 1,2-dichloroethane (10 mL) at room temperature was stirred for 16 hours at 75 °C, diluted with dichloromethane, washed with water, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 0-5% methanoPdichloromethane to provide the desired product. MS (ESI(-)) m/e 388 (M-H) " . Example 195C 4-((2,2-difluoro-2-(phenylthio)ethyl)amino)-N-((4 '-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 195B for Example IC in Example iD. MS (ESI(-)) m/e 586 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.73 (t, IH), 8.64 (d, IH), 7.99 (dd, IH), 7.95 (d, 2H), 7.71-7.80 (m, 4H), 7.59-7.64 (m, 2H), 7.54-7.43 (m, 3H), 7.36-7.27 (m, 3H), 4.37-4.24 (m, 2H). Example 196 N-(4-(l-butyl-2-oxo-2,3-dihydro-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 166D and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 644 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ.0.90 (t, 3H), 1.30 (qt, 2H), 1.65 (tt, 2H), 3.28 (t, 2H), 3.61 (dt, 2H), 3.82 (t, 2H), 7.02 (d, IH), 7.16-7.25 (m, 3H), 7.31 (d, 2H), 7.35 (dd, IH), 7.40 (d, 2H), 7.58 (d, 2H), 7.90 (dd, IH), 7.95 (d, 2H), 8.50 (t, IH), 8.52 (d, IH), 10.90 (s, IH). Example 197 N-(4-(8-azaspiro(4.5)dec-8-vPberιzoyP-4-((2,2-difluoro-2-(phenylthio)ethypamino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 257C and Example 195B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 629 (M-H) " ; H NMR (300 MHz, DMSO-d6) δ 8.77 (t, IH), 8.64 (d, IH), 7.99 (dd, IH), 7.71 (d, 2H), 7.61 (d, 2H), 7.42-7.52 (m, 3H), 7.36 (d, IH), 6.91 (d, 2H), 4.27-4.37 (m, 2H), 1.56-1.63 (m, 4H), 1.38-1.48 (m, 6H). Example 198 3-nitro-N-(4-( 1 -octyl- 1 H-pyrazol-4-yl)benzoyl)-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 198A 4-iodo- 1 -octyl- 1 H-pyrazole A solution of 4-iodopyrazole (11.25 g, 6.44 mmol) in DMF (20 mL) at room temperature was treated with 60% NaH (271 mg, 6.77 mmol), stirred for 10 minutes, treated with 1-bromooctane (1.22 mL, 7.08 mmol), stirred for 30 minutes, poured into water, and extracted three times with ether/hexanes. The combined extracts were washed with water and brine, dried (MgSO 4 ), fUtered, and concentrated to provide the desired product. MS (ESI(+)) m/e 307 (M+H) + . Example 198B 4-( 1 -octyl- 1 H-pyrazol-4-yPbenzoic acid The desired product was prepared by substituting Example 198A for 6-bromoindole in Example 4A. MS (ESI(-)) m/e 299 (M-H) " . Example 198C 3-nitro-N-(4-(l-octyl-lH-ρyrazol-4-vPbenzovP-4-((2- (phenylthio ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 77B and Example 198B for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 634 (M-H) " . IT NMR (300 MHz, DMSO-de) δ 0.83 (t, 3H), 1.23 (m, 10H), 1.79 (tt, 2H), 3.37 (t, 2H), 3.61 (q, 2H), 4.09 (t, 2H), 7.00 (d, IH), 7.20 (d, IH), 7.30 (t, 2H), 7.40 (d, 2H), 7.51 (d, 2H), 7.87 (t, 2H), 7.89 (dd, IH), 8.21 (s, IH), 8. 51 (d, IH), 8.55 (t, IH). Example 199 N-r4-(4-r2-π.3-dioxan-2-vPethylidene)piperidin-l-yl)benzoyl)-3-nitro-4- 2- (phenylthio)ethyl)amino)benzenesulfonamide Example 199A ethyl 4-(4-(2-( 1 ,3-dioxan-2-yl) ethylidene)piperidin- 1 -ypbenzoate The desired product was prepared by substituting (2-( 1 ,3-dioxan-2- yl)ethyl)triphenylphosphonium bromide for methyltriphenylphosphonium bromide in Example 158C. MS (DCI) m/e 346 (M+H) + . Example 199B 4-(4-(2-(l,3-dioxan-2-yl)ethylidene)piperidin-l-yl)benzoic acid The desired product was prepared by substituting Example 199A for Example 119B in Example 119C. MS(DCI) m/e 318 (M+H) + . Example 199C N-(4-(4-(2-( 1 ,3-dioxan-2-vPethylidene piperidin- 1 -vPbenzovP-3-nitro-4-((2- (phenylthio)ethvPamino benzenesulfonamide The desired product was prepared by substituting Example 199B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 651; H NMR (300 MHz, DMSO-d 6 ) δ 11.97 (s, IH), 8.77 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.74 (d, 2H), 7.37 (dd, 2H), 7.31-7.14 (m, 4H), 6.93 (d, 2H), 5.23 (t, IH,), 4.48 (t, IH), 3.97 (dd, 2H), 3.72-3.61 (m, 4H), 3.39 (t, 4H), 3.31 (m, 2H), 2.23 (m, 6H), 1.91-1.78 (m, IH), 1.32 (m, IH). Example 200 4-(3-(2-methoxy-4'-(r(;(3-nitro-4-r(2- (phenylthio)ethyl)amino)phenyPsulfonyPamino)carbonyl)-l , 1 '-biphenyl-4-yl)propyι)-N,N- dimethylpiperazine- 1 -carboxamide A solution of Example 183D (108 mg, 0.157 mmol) and triethylamine (45 μL, 0.32 mmol) in THF (2 mL) at room temperature was treated with dimethylcarbamic chloride (14 uL, 0.157 mmol), and stirred for 30 minutes. The mixture was purified by flash column chromatography on silica gel with 10: 10:80 methanol/acetonitrUe/ethyl acetate to provide the desired product. MS (ESI(-)) m/e 759 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.93 (m, 2H), 2.65 (t, 2H), 2.74 (s, 6H), 2.89 (m, 2H), 3.08 (m, 4H), 3.34 (m, 6H), 3.61 (m, 2H), 3.75 (s, 3H), 6.88 (d, IH), 6.96 (s, IH), 7.01 (d, IH), 7.21 (m, 2H), 7.30 (t, 2H), 7.41 (m, 3H), 7.88 (d, IH), 7.89 (d, 2H), 8.51 (d, IH), 8.54 (t, IH). Example 201 N-(4-(5-(3-(4-methylpiperazin-l-yl)-3-oxopropyl)quinolin-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 201 A 5-iodoquinolin-8-ol A solution of 8-hydroxyquinoHne (25.00 g, 172 mmol), sodium iodide (27.10 g, 181 mmol), and 6M NaOH (30.14 mL, 181 mmol) in methanol at 0 °C was treated with 5.25% aqueous NaOCl (13.46 g, 181 mmol) dropwise over 4 hours, stirred for 16 hours, adjusted to pH 7 with 6M HCl and pH 7 buffer, and extracted with 5% methanol in ethyl acetate (3 x 200 mL). The combined extracts were washed with brine (100 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was dissolved in 10% methanol/ethyl acetate and filtered. The filtrate was dried (Na 2 SO 4 ), filtered, and concentrated to provide the desired product. Example 20 IB 8-((tert-butyl(dimethypsilvPoxy)-5-iodoquinoHne A mixture of Example 201A (10.40 g, 38.4 mmol), tert-butyldimethylsUyl chloride (6.07g, 40.3 mmol), and imidazole (5.49g, 80.6 mmol) in DMF (75 mL) at room temperature was stirred for 16 hours, treated with water (300 mL), and extracted with diethyl ether (3 x 400 mL). The combined extracts were washed with brine (100 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 10% ethyl acetate/hexanes to provide the desired product. Example 20 IC tert-butyl (2E)-3-(8-((tert-butyl(dimethyl)silyl)oxy)quinoHn-5-yl)prop-2-enoate A mixture of Example 201B (5.00 g, 13.0 mmol), tert-butylacrylate (2.00 g, 15.6 mmol), paUadium(II) acetate (175 mg, 0.78 mmol), and tri-o-tolylphosphine (951 mg, 3.12 mmol) in a sealed tube with triethylamine (8 mL) and acetonitrUe (38 mL) was heated to 120 °C for 16 hours and then concentrated. The concentrate was purified by flash column chromatography on silica gel with 10-100% ethyl acetate/hexanes to provide the desired product. Example 20 ID tert-butyl 3-(8-((tert-butyl(dimethyl)silyl)oxy quinoHn-5-yl)propanoate A mixture of Example 201C (4.03g, 10.5 mmol) and Rh(PPh 3 ) Cl (972 mg, 1.05 mmol) in toluene (40 mL) was degassed and flushed with hydrogen three times. The solution was heated to 60 °C under a hydrogen atmosphere for 16 hours and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 5-10% ethyl acetate/hexanes to provide the desired product. Example 201E tert-butyl 3-(8-hydroxyquinolin-5-yPpropanoate The desired product was prepared by substituting Example 20 ID for Example 177A in Example 177B. Example 20 IF tert-butyl 3-(8-(((trifluoromethyl)sulfonyl)oxy)quinolin-5-yl)propanoate A mixture of Example 201E (1.57 g, 5.74 mmol), N-(2-pyridyl)triflimide (2.16 g, 6.03 mmol), and N,N-dusopropylethylamine (816 mg, 6.31 mmol) in dichloromethane (25 mL) was heated to reflux for 16 hours and then concentrated. The concentrate was purified by flash column chromatography on silica gel with 30% ethyl acetate/hexanes to provide the desired product. Example 201G methyl 4-(5-(3-tert-butoxy-3-oxopropyl)quinolin-8-yPbenzoate The desired product was prepared by substituting Example 20 IF for Example 5A in Example 5B. Example 20 IH 3-(8-(4-(methoxycarbonyl)phenyl)quinolin-5-yPpropanoic acid A mixture of Example 201G (1.26 g, 3.22 mmol) and triethylsilane (1.12 g, 9.66 mmol) in TFA (10 mL) was heated to 50 °C for 16 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5% methanol/ethyl acetate to provide the desired product. Example 2011 methyl 4-(5-(3-chloro-3-oxopropyPquinoUn-8-yPbenzoate A solution of Example 201H (1.65 g, 4.92 mmol) in dichloromethane (15 mL) at room temperature was treated oxalyl chloride (344 mg, 2.71 mmol), stirred for 20 minutes, treated with toluene (25 mL), and concentrated to provide the desired product. Example 201 J methyl 4-(5-(3-(4-methylpiperazin- 1 -yP-3-oxopropyl)quinoHn-8-ypbenzoate A mixture of Example 2011 (300 mg, 0.85 mmol), 1-methylpiperazine (111 mg, 1.11 mmol), and pyridine (74 mg, 0.94 mmol) in dioxane (4 mL) at room temperature was stirred for 75 minutes and purified by flash column chromatography on sUica gel with 90: 10:0.5 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired product. Example 20 IK 4-(5-(3-(4-methylpiperazin-l-yl)-3-oxopropyl)quinolin-8-yl)benzoic acid The desired product was prepared by substituting Example 201 J for Example 1A in Example IB. Example 20 IL N-(4-(5-(3-(4-methylpiperazin-l-yP-3-oxopropyl)quinolin-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 20 IK and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 737, 739 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.37 (s, 3H), 2.53 (m, 4H), 2.78 (t, 2H), 3.17 (t, 2H), 3.27 (t, 2H), 3.40-3.57 (m, 4H), 3.61 (dt, 2H), 7.01 (d, IH), 7.20 (tt, IH), 7.31 (t, 2H), 7.40 (d, 2H), 7.54-7.62 (m, 4H), 7.68 (d, IH), 7.90 (dd, IH), 7.96 (d, 2H), 8.52 (d, IH), 8.54 (t, IH), 8.57 (d, IH), 8.89 (dd, IH). Example 202 tert-butv! 4-(3-(2-methoxy-4'-(;(;(;(;3-nitro-4-r(2- (phenylthio)ethyl)amino)phenyPsulfonyl)amino)carbonyP-l , 1 '-biphenyl-4- yPpropyPpiperazine- 1 -carboxylate The desired product was prepared by substituting (BOC) 2 θ for dimethylcarbamic chloride in Example 200. MS (ESI(-)) m/e 788 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.93 (m, 2H), 2.65 (t, 2H), 2.74 (s, 6H), 2.89 (m, 2H), 3.08 (m, 4H), 3.34 (m, 6H), 3.61 (m, 2H), 3.75 (s, 3H), 6.86 (d, IH), 6.96 (s, IH), 7.01 (d, IH), 7.21 (m, 2H), 7.31 (t, 2H), 7.40 (m, 4H), 7.89 (d, 2H), 8.51 (d, IH), 8.54 (t, IH). Example 203 N-(4-r4-(2-(l,3-dioxan-2-vPethyPpiperidin-l-vPbenzovP-3-nitro-4-((2- (phenylthio)ethyPamino benzenesulfonamide Example 203A ethyl 4-(4-(2-( 1 ,3-dioxan-2-vD ethyppiperidin- 1 -yPbenzoate A mixture of Example 199A (1.2 g, 3.6mmol), Pd/C (0.42 g), and ethyl acetate (25 mL) was hydrogenated at 4 atmospheres in a Parr shaker at room temperature for 3 days. The catalyst was removed by filtration, solvent was evaporated, and the crude product was purified by flash column chromatography on sUica gel with 30% ethyl acetate/hexanes to provide the desired product. MS(DCI) m/e 348 (M+H) . Example 203B 4-(4-(2-( 1 ,3-dioxan-2-yl)ethyPpiperidin- 1 -yPbenzoic acid The desired product was prepared by substituting Example 203 A for Example 119B in Example 119C. MS(DCI) m/e 320 (M+H) + . Example 203C N-r4-r4-(2-C1.3-dioxan-2-yl)ethvPpiperidin-l-yPbenzovP-3-nitro-4-((2- (phenylthio) ethyl) amino benzenesulfonamide The desired product was prepared by substituting Example 203B and Example 77B for Example IB and Example IC, respectivley, in Example ID to obtain the desired product. MS (ESI(-)) m/e 653; H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.77 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.72 (d, 2H), 7.37 (m, 2H), 7.14-7.31 (m, 4H), 6.91 (d, 2H), 4.47 (t, IH), 3.87-3.99 (m, 4H), 3.62-3.70 (m, 4H), 3.30 (m, 4H), 2.78 (m, 2H), 1.75-1.90 (m, IH), 1.70 (m, 2H), 1.48 (m, 2H), 1.22-1.32 (m, 3H) 1.05-1.13 (m, IH). Example 204 N-(2-(dimethylamino ethvP-3-(2-methoxy-4'-((( , (4-(((lR)-2-r4-methylpiperazin-l-vP-l- ((phenylthio)methyl)ethyl)amino -3-nitrophenyPsulfonvPamino)carbonyl)- 1 , 1 '-biphenyl-4- yl) -N-methylpropanamide The desired product was prepared by substituting Example 148C and Example 178B for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m e 830 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 2.42-2.59 (m, 2H), 2.68 (s, 6H), 2.71 (s, 3H), 2.89 (m, 2H), 3.02 (m, 2H), 3.14 (s, 3H), 3.29 (m, 12H), 3.62 (m, 2H), 3.75 (s, 3H), 4.04 (m, IH), 6.89 (d, IH), 6.94 (s, IH), 6.98 (d, IH), 7.18 (m, 2H), 7.26 (t, 2H), 7.37 (m, 3H), 7.84 (d, IH), 7.89 (d, 2H), 8.46 (d, IH), 8.54 (t, IH). Example 205 methyl 4-(3-r2-methoxy-4'-((((3-nitro-4-((;2- (phenylthio)ethyl)amino phenyPsulfonvPamino)carbonyl)-l , 1 '-biphenyl-4- yppropyPpiperazine- 1 -carboxylate The desired product was prepared by substituting methyl chloroformate for dimethylcarbamic chloride in Example 200. MS (ESI(-)) m/e 746 (M-H) " ; X H NMR (300 MHz, DMSO-de) δ 1.79 (m, 2H), 2.35 (m, 4H), 2.61 (t, 2H), 3.28 (t, 2H), 3.35 (m, 6H), 3.59 (s, 3H), 3.61 (m, 2H), 3.74 (s, 3H), 6.85 (d, IH), 6.94 (s, IH), 6.98 (d, IH), 7.20 (m, 2H), 7.31 (t, 2H), 7.40 (m, 3H), 7.88 (d, IH), 7.89 (d, 2H), 8.51 (d, IH), 8.52 (t, IH). Example 206 N-(4-t;8-azaspiro(4.5 dec-8-vPbenzovP-4-(;((lRV2-((2- (dimethylamino) ethyl) (methyl) amino)- 1 -((phenylthio)methyl) ethyl) amino)-3 - nitrobenzenesulfonamide Example 206A tert-butyl ( 1 R)-2-((2-(dimethylamino)ethvP methyPamino)- 1 - ((phenylthio)methyl)ethylcarbamate The desired product was prepared by substituting N, N, N'-trimethylethylenediamine for dimethylamine in Example 134B. MS (ESI(-)) m/e 366 (M-H) " . Example 206B (2R)-N -(2-(dimethylamino ethyP-N -methyl-3-(phenylthio)propane-l ,2-diamine The desired product was prepared by substituting Example 206A for Example 133A in Example 133B. Example 206C 4-(((lR)-2-((2-(dimethylamino)ethyP(methyl)ammo)-l-((phenyltMo methyPethyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 122C and Example 206B for Example ID and 2,2-dimethylcyclopentylamine, respectively, in Example IE. MS (ESI(-)) m/e 466 (M-H) " . Example 206D N-(4-(8-azaspiro(4.5)dec-8-vPbenzovP-4-f(Y lRl-2-((2- (dimethylamino) ethyl) (methyl) amino)- 1 -((phenylthio)methyl) ethyl) amino)-3 - nitrobenzenesulfonamide The desired product was prepared by substituting Example 257C and Example 206C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 707 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 1.41 (m, 4H), 1.48 (m, 4H), 1.59(m, 4H), 2.23 (m, 2H), 2.64 (s, 6H), 2.67 (s, 3H), 2.72 (m, 2H), 3.20 (m, 4H), 3.26-3.42 (m, 5H), 6.81 (d, 2H), 6.97 (d, IH), 7.18 (dd, IH), 7.21 (dd, 2H), 7.31 (d, 2H), 7.72 (d, 2H), 7.82 (dd, IH), 8.20 (d, IH), 8.43 (s, IH). Example 207 N-(4-(4-(2-amino-3-phenylpropyl)piperazin-l-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 173B for Example 120D in Example 120E. MS (ESI(-)) m/e 673 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.77 (d, 2H), 7.12-7.40 (m, 9H), 6.90-7.04 (m, 2H), 3.60- 3.72 (m, 4H), 3.26-3.40 (m, 6H), 2.98-3.08 (m, 2H), 2.70-2.84 (m, 4H). Example 208 4-(((4-(aminomethyl)bicyclo(2.2.2)oct-l-yl)methyl)amino)-N-((2'-methoxy-4'-(3-morpholin- 4-ylpiOpyl)-l , 1 '-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide Example 208A tert-butyl (4-(((4-((((2'-methoxy-4'-(3-morpholin-4-ylpropyP-l,r-biphenyl-4- ypcarbonvPamino)sulfonyP-2-nitrophenyPamino)methyPbicyclo(2.2.2)oct-l- ypmethylcarbamate The desired product was prepared by substituting Example 1220 and Example 162A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 804 (M-H) " Example 208B 4-(((4-(aminomethyl)bicvclo(2.2.2)oct-l-yl)methyl)amino)-N-((2'-methoxy-4'-(3-morpholin- 4-ylpropyl)- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 208A for Example 120D in Example 120E. MS (ESI(-)) m/e 704 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.3 (br s, IH), 8.65 (d, IH), 8.48 (d, IH), 7.95 (dd, IH), 7.92 (d, 2H), 7.66 (br s, 2H), 7.56 (d, 2H), 7.32 (d, IH), 7.26 (d, IH), 7.02 (d, IH), 6.93 (dd, IH), 3.92-4.02 (m, 2H), 3.78 (s, 3H), 3.38- 3.47 (m, 2H), 3.26-3.37 (m, 4H), 3.10 (br s, 2H), 2.63-2.76 (m, 4H), 2.52-2.60 (m, 2H), 2.01- 2.08 (m, 2H), 1.42-1.55 (m, 12H). Example 209 N-(4-((4-butylbenzyl)oxy)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 209A methyl 4-((4-butylbenzyl)oxy)benzoate A solution of triphenylphosphine (656 mg, 2.50 mmol) in THF (12 mL) at 0 °C was treated with diethyl azodicarboxylate (442 mg, 2.54 mmol), stirred for 20 minutes, treated with ethyl 4-hydroxybenzoate (350 mg, 2.30 mmol) and 4-butylbenzyl alcohol (414 mg, 2.52 mmol), warmed to room temperature, stirred for 16 hours, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 30% ethyl acetate/hexanes to provide the desired product. Example 209B 4-((4-butylbenzyl)oxy)benzoic acid The desired product was prepared by substituting Example 209A for Example 1 A in Example IB. Example 209C N-(4-((4-butylbenzvPoxy)benzoyp-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 209B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 618 (M-H) " ;1H NMR (300 MHz, DMSO-de) δ.0.88 (t, 3H), 1.29 (tq, 2H), 1.54 (tt, 2H), 2.57 (t, 2H), 3.28 (t, 2H), 3.63 (dt, 2H), 5.08 (s, 2H), 6.96 (d, 2H), 7.06 (d, IH), 7.19 (d, 2H), 7.21 (s, IH), 7.34 (m, 6H), 7.83 (d, 2H), 7.88 (dd, IH), 8.54 (d, IH), 8.61 (t, IH). Example 210 4-(3-(2-methoxy-4'-((((3-nitro-4-((2- (phenylthio)ethyl)amino)phenyPsulfonyl)amino)carbonyl)-l , 1 '-biphenyl-4-yl)propyι)-N,N- dimethylpiperazine- 1 -sulfonamide The desired product was prepared by substituting dimethylsulfamoyl chloride for dimethylcarbamic chloride in Example 200. MS (ESI(-)) m/e 795 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 1.89 (m, 2H), 2.65 (m, 2H), 2.77 (s, 6H), 2.84 (m, 2H), 3.10 (m, 8H), 3.28 (m, 2H), 3.63 (dd, 2H), 3.76 (s, 3H), 6.89 (d, IH), 6.97 (s, IH), 7.09 (d, IH), 7.21 (m, 2H), 7.29 (t, 2H), 7.39 (m, 2H), 7.47 (d, 2H), 7.88 (d, IH), 7.90 (dd, IH), 8.55 (d, IH), 8.64 (t, IH). Example 211 4-(((lR)-2-(2,5-(HoxopyrroHdin-l-yl)-l-((phenylthio)methyl)ethyl)amino)-N-((2'-methoxy- 4'-(3-morphoHn-4-yl-3-oxopropyl)-l,r-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide A solution of succinimide (24 mg, 0.245 mmol), triphenylphosphine (71 mg, 0.27 mmol), and DEAD (43 uL, 0.27 mmol) in THF (3 mL) at room temperature was treated with Example 28 IB (90 mg, 0.122 mmol), stirred for 30 minutes, and purified by flash column chromatography on silica gel with 5% methanol/ethyl acetate to provide the desired product. MS (ESI(-)) m/e 814 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.79 (m, 2H), 2.35 (m, 4H), 2.61 (t, 2H), 3.28 (t, 2H), 3.35 (m, 6H), 3.59 (s, 3H), 3.61 (m, 2H), 3.74 (s, 3H), 6.91 (d, IH), 7.01 (s, IH), 7.03 (d, IH), 7.16 (m, IH), 7.21 (t, 2H), 7.31 (m, 2H), 7.56 (d, 2H), 7.89 (d, 3H), 8.37 (d, IH), 8.54 (t, IH). Example 212 N-(4-(8-azaspiro(4.5)dec-8-yPbenzoyP-4-( 3-(dimethylamino)-2-(phenylthio)propyPamino)- 3-nitrobenzenesulfonamide Example 212A 2-cyano-N,N-dimethyl-2-(phenylthio)acetamide A suspension of 2-bromo-2-cyano-N,N-dimethylacetamide '(3.80 g, 20 mmol), potassium carbonate (2.902 g, 21 mmol) and thiophenol (2.314 g, 21 mmol, 2.16 mL) in acetonitrUe (20 mL) was heated to 50 °C for 3 days. The mixture was dUuted with water (100 mL) and extracted with ethyl acetate (2 x 50 mL). The combined extracts were combined and concentrated. The concentrate was purified by column chromatography on sUica gel with 0-50% ethyl acetate/hexanes to provide the desired product. MS (ESI(+)) m/e 221 (M+H) + . Example 212B N,N-dimethyl-2-(phenylthio)piOpane-l,3-diamine Example 212A (0.76 g, 3.45 mmol) was treated with IM BH 3 THF (15 mL), stirred at room temperature for 18 hours, quenched with methanol (5 mL), and concentrated. The concentrate was heated with 2M HCl (50 mL) concentrated, treated with 40 % KOH (1-2 mL) and extracted with dichloromethane (25 mL x 2). The combined extracts were dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (ESI(+)) m/e 211 (M+H) + . Example 212C 4-((3-((hmethylamino)-2-(phenylthio)propypamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 212B for Example 195A in Example 195B. MS (ESI(-)) m/e 409 (M-H) " . Example 212D N-(4-(8-azaspiro(4.5)dec-8-yl)berιzoyl)-4-((3-(dimethylamino)-2-(phenylthio)propyl)amino)- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 257C and Example 212C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 650 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.98 (t, IH), 8.56 (d, IH), 7.88 (dd, IH), 7.71 (d, 2H), 7.48-7.44 (m, 2H), 7.35-7.26 (m, 3H), 7.02 (d, IH), 6.87 (d, 2H), 3.82-3.79 (m, IH), 3.67- 3.59 (m, 2H), 3.32-3.24 (m, 4H), 2.86-2.67 (m, 2H), 2.39 (br s, 6H), 1.61-1.56 (m, 4H), 1.51- 1.40 (m, 8H). - Example 213 N-(4-(2-but-3-enyl-l,3-benzothiazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 213A 5-bromo-2-but-3-enyl- 1 ,3-benzothiazole A solution of 5-bromo-2-methylbenzothioazole (1.00 g, 4.38 mmol) in THF (25 mL) at -78 °C was treated with 1.5M LDA in cyclohexane (4.40 mL, 6.60 mmol), stirred for 45 minutes, treated with aUyl bromide (1.33 g, 10.99 mmol), stirred for 1 hour, quenched with IM HCl, warmed to room temperature, added to water (50 mL), and extracted with ethyl acetate (3 x 200 mL). The combined extracts were washed with brine (25 mL), dried (Na 2 SO 4 ), fUtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 8% ethyl acetate/hexanes to provide the desired product. Example 213B 4-(2-but-3-enyl-l,3-benzothiazol-5-yl)benzoic acid The desired product was prepared by substituting Example 213A for 6-bromoindole in Example 4A. Example 213C N-(4-(2-but-3-enyl- 1.3-benzothiazol-5-vPbenzoyl)-3-nitro-4-((2- (phenyltMo ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 213B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m e 643, 645 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.59 (dt, 2H), 3.24 (t, 2H), 3.26 (t, 2H), 3.61 (dt, 2H), 5.02 (dq, IH), 5.14 (dq, IH), 5.92 (m, IH), 7.02 (d, IH), 7.19 (tt, IH), 7.30 (t, 2H), 7.39 (d, 2H), 7.74 (d, 3H), 7.89 (dd, IH), 7.97 (d, 2H), 8.10 (d, IH), 8.22 (d, IH), 8.54 (d, IH), 8.56 (t, IH). Example 214 . N-(4-(l-((l-hy(iroxycyclohexyl)methyl)-lH-benzimidazol-5-yPbenzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 214A l-(((2-amino-4-bromophenyl)amino)methyl)cyclohexanol The desired product was prepared by substituting 1-aminomethyl-l-cyclohexanol hydrochloride for butylamine in Examples 166A, adding 2M NaOH (2.5 mL) to the reaction, and then substituting the resulting product for Example 166 A in Example 166B. Example 214B 1 -((5-bromo-lH-benzimidazol- 1 -ypmethypcyclohexanol The desired product was prepared by substituting Example 214A for Example 170A in Example 170B. Example 214C 4-( 1 ,3,2-dioxaborinan-2-yp benzoic acid A mixture of 4-(dihydroxyboryl)benzoic acid (30.00 g, 181 mmol) and 1,3- propanediol (15.20 g, 200 mmol) in toluene (750 mL) at 140 °C was stirred for 6 hours whUe coUecting the water removed by azeotrope formation. The mixture was concentrated to provide the desired product. Example 214D N-(4-π,3,2-dioxaborinan-2-yPbenzovP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 214C and Example 77B for Example IB and Example IC, respectively, in Example ID. Example 214E N-(4-borylbenzoyl)-3-nitro-4-((2-(phenylthio)ethvPamino)benzenesulfonamide A solution of Example 214D (26.26 g, 48.5 mmol) in THF (250 mL) at room temperature was treated with 2M KOH (225 mL), stirred for 16 hours, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 70- 100% ethyl acetate/hexanes to provide the desired product. Example 214F N-(4-( !-(( 1 -hydroxycyclohexyPmethyP- 1 H-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 214B and Example 214E for 6-bromoindole and 4-(dihydroxyboryl)benzoic acid in Example 4A. MS (ESI) m/e 684, 686 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.17-1.58 (m, 10H), 3.27 (t, 2H), 3.61 (dt, 2H), 4.15 (s, 2H), 4.58 (s, IH), 7.00 (d, IH), 7.20 (tt, IH), 7.31 (td, 2H), 7.40 (d, 2H), 7.49-7.58 (m, 2H), 7.65 (d, 2H), 7.73 (d, IH), 7.89 (dd, IH), 7.96 (d, 2H), 8.14 (s, IH), 8.52 (d, IH), 8.53 (t, IH). Example 215 tert-butyl 2-((4-(4-((((3-nitro-4-((2- (phenylthio)ethvPamino)phenvPsulfonvPamino)carbonvPphenyl)piperazin-l- yPmethvPpyrroHdine- 1 -carboxylate The desired product was prepared by substituting 2-formylpyrrolidine-l -carboxylic acid tert-butyl ester for (l-benzyl-2-oxo-ethyl)-carbamic acid tert-butyl ester in Example 173B. MS (ESI(-)) m/e 723 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.61 (t, IH), 8.53 (d, IH), 7.88 (dd, IH), 7.73 (d, 2H), 7.38 (d, 2H), 7.30-7.25 (m, 2H), 7.21-7.15 (m, IH), 7.07 (d, IH), 6.87 (d, 2H), 3.88-3.78 (m, IH), 3.62 (q, 2H), 3.18-3.30 (m, 10H), 2.72-2.60 (m, 2H), 2.38-2.26 (m, 2H), 1.90-1.76 (m, 4H), 1.40 (s, 9H). Example 216 N.N-(hrnethyl-3-(8-(4-((((3-rutiO-4-(T2- (phenylthio)ethyl)-miino)phenvP The desired product was prepared by substituting dimethylamine for 1- methylpiperazine in Example 201. MS (ESI(-)) m e 682 (M-H) " ; ^ MR (300 MHz, DMSO-de) δ 2.73 (t, 2H), 2.83 (s, 3H), 2.92 (s, 3H), 3.26 (t, 2H), 3.28 (t, 2H), 3.65 (dt, 2H), 7.15 (d, IH), 7.19 (tt, IH), 7.29 (td, 2H), 7.38 (d, 2H), 7.55-7.62 (m, 2H), 7.66 (d, 2H), 7.69 (d, IH), 7.90-7.98 (m, 3H), 8.57 (d, IH), 8.60 (t, IH), 8.70 (m, IH), 8.88 (dd, IH). Example 217 N-((2'-methoxy-4 '-(( 1 E)-3 -morphohn-4-yl-3 -oxoprop- 1 -envP- 1.1 '-biphenyl-4-yP carbonyl)-3 - nitro-4-f (2-f phenylthio) ethyl) amino benzenesulfonamide Example 217A ethyl 2'-methoxy-4'-((lE)-3-morphoHn-4-yl-3-oxoprop-l-enyl)-l,r-biphenyl-4-carboxylate The desired product was prepared by substituting Example 122L and morphohne for Example IB and Example IC, respectively, in Example ID. Example 217B 2'-methoxy-4'-(( IE) -3 -morphohn-4-yl-3 -oxoprop- 1 -en l)- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 217A for Example 1 A in Example IB. MS (ESI(-)) m/e 366 (M-H) " . Example 217C N-((2'-methoxy-4'-(( 1 E)-3-morphoHn-4-yl-3-oxoprop-l-enyP- 1 , 1 '-biphenyl-4-yl)carbonyP-3- nitro-4-((2-(phenylt o)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 217B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 701 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 3.25 (m, 4H), 3.47 (m, 2H), 3.61 (m, 4H), 3.68 (s, 3H), 3.72 (dd, 2H), 4.58 (d, IH), 6.92 (m, 3H), 7.20 (t, IH), 7.31 (m, 3H), 7.40 (m, 4H), 7.58 (dd, IH), 7.90 (m, 3H), 8.48 (m, 2H). Example 218 isobutyl 4-r3-r2-methoxy-4'-((((3-nitro-4-((;2- (phenylthio)ethyPamino)phenyPsulfonyl)amino)carbonyP-l , 1 '-biphenyl-4- yppropyppiperazine- 1 -carboxylate The desired product was prepared by substituting isobutyl chloroformate for dimethylcarbamic chloride in Example 200. MS (ESI(-)) m/e 788 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.89 (d, 6H), 1.80 (m, 2H), 1.85 (m, IH), 2.39 (m, 4H), 2.62 (t, 2H), 3.28 (t, 2H), 3.40 (m, 4H), 3.59 (m, 3H), 3.73 (s, 3H), 3.79 (dd, IH), 4.02 (m, IH), 6.86 (d, IH), 6.94 (s, IH), 6.98 (d, IH), 7.20 (m, 2H), 7.31 (t, 2H), 7.40 (m, 3H), 7.88 (d, IH), 7.89 (d, 2H), 8.50 (d, IH), 8.52 (t, IH). Example 219 3-mtro-4-rr2-(phenyltMo ethvPamino -N-(4-(1.8.8-trimethyl-3-azabicvclo(3.2.1)oct-3- vPbenzoyPbenzenesulfonamide Example 219A methyl 4-(l, 8, 8-trimethyl-2,4-dioxo-3-azabicvclo(3.2.1)oct-3-yl)benzoate The desired product was prepared by substituting methyl 4-aminobenzoate and (+/-)- camphoric anhydride for ethyl 4-aminobenzoate and 3,3-dimethylglutaric anhydride, respectively, in Example 119A. MS (DCI) m/e 333 (M+NH 4 ) + . Example 219B methyl 4-(l,8,8-trimethyl-3-azabicyclo(3.2. l)oct-3~yι)benzoate The desired product was prepared by substituting Example 219A for Example 119A in Example 119B. MS (DCI) m/e 288 (M+H) + . Example 219C 4-(l,8,8-trimethyl-3-azabicyclo(3.2. l oct-3-yl)benzoic acid The desired product was prepared by substituting Example 219B for Example 119B in Example 119C. MS (DCI) m/e 274 (M+H) + . Example 219D 3-nitro-4-((2-(phenylthio)ethyPamino -N-(4-(l,8,8-trimethyl-3-azabicyclo(3.2.1)oct-3- ypbenzoypbenzenesulfonamide The desired product was prepared by substituting Example 219C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 607 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.76 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.74 (d, 2H), 7.37 (d, 2H), 7.15-7.29 (m, 4H), 6.80 (d, 2H), 3.67 (m, 2H), 3.43 (d, IH), 3.29 (m, 2H), 3.15 (m, 2H), 2.85 (d, IH, J=l 1.5), 1.90 (m, 2H), 1.60 (m, 2H), 1.40 (m, IH), 0.91 (m, 9H). Example 220 3-nitro-4-((2-(phenyltMo)ethvPamino)-N-(4-pyιτolidin-l-ylbenzoyl)benzenesulfonamide Example 220A methyl 4-(2,5-dioxopyrroHdin-l-yl)benzoate The desired product was prepared by substituting methyl 4-aminobenzoate and succinic anhydride for ethyl 4-aminobenzoate and 3,3-dimethylglutaric anhydride, respectively, in Example 119A. MS (DCI) m/e 251 (M+NH 4 ) Example 220B methyl 4-pyrroHdin-l-ylbenzoate The desired product was prepared by substituting Example 220A for Example 119A in Example 119B. MS (DCI) m/e 206 (M+H) + . Example 220C 4-pyrroHdin-l-ylbenzoic acid The desired product was prepared by substituting Example 220B for Example 119B in Example 119C. MS (DCI) m/e 192 (M+H) + . Example 220D 3 -nitro-4-((2-(phenylthio) ethyl) amino)-N-(4-pyrrolidin- 1 -ylbenzoypbenzenesulfonamide The desired product was prepared by substituting Example 220C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 527 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 11.87 (s, IH), 8.77 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.73 (d, 2H), 7.37 (d, 2H), 7.15-7.28 (m, 4H), 6.53 (d, 2H), 3.67 (m, 2H), 3.30 (m, 6H), 1.95 (m, 4H). Example 221 N-(4-(5-(3-morphoHn-4-yl-3-oxopropyPquinoHn-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting morphohne for 1-methylpiperazine in Example 201. MS (ESI) m/e 724, 726 (M-H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 2.76 (t, 2H), 3.27 (t, 2H), 3.29 (t, 2H), 3.34-3.53 (m, 8H), 3.60 (dt, 2H), 6.99 (d, IH), 7.20 (t, IH), 7.31 (t, 2H), 7.40 (d, 2H), 7.50-7.61 (m, 4H), 7.67 (d, IH), 7.89 (d, IH), 7.95 (d, 2H), 8.50 (t, IH), 8.51 (d, IH), 8.56 (d, IH), 8.89 (d, IH). Example 222 N-((4'-(3-(4-acetylpiperazin- 1 -yl)propyl)-2'-methoxy-l , 1 '-biphenyl-4-yl)carbonyP-3-nitro-4- ((2-(phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared from acetyl chloride for dimethylcarbamic chloride in Example 200. MS (ESI(-)) m/e 703 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.91 (m, 2H), 2.01 (s, 3H), 2.67 (m, 4H), 2.72 (m, 2H), 3.28 (m, 4H), 3.59 (m, 6H), 3.75 (s, 3H), 4.05 (dd, IH), 6.88 (d, IH), 6.95 (s, IH), 7.01 (d, IH), 7.20 (m, 2H), 7.31 (t, 2H), 7.40 (m, 3H), 7.70 (d, IH), 7.89 (d, 2H), 8.51 (d, IH), 8.54 (t, IH). Example 223 N-(4-(l-(cyclohexylmethyl)-2-oxo-2,3-dihydro-lH-benzJmidazol-5-yl)benzoyl)-3-nitro-4- ((2-(phenylthio)ethyl)amino)benzenesulfonamide Example 223A 4-( 1 -(cyclohexylmethyl)-2-oxo-2.3-dihydro- 1 H-benzimidazol-5-yPbenzoic acid The desired product was prepared by substituting cyclohexylmethylamine for n- butylamine in Examples 166A, 166B, 166C, and 166D. Example 223B N-(4-(l-(cyclohexylmethyl)-2-oxo-2,3-dihydro-lH-benzimidazol-5-yl)benzoyP-3-nitro-4- ((2-(pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 223A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 684, 686 (M- H) " ; (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 0.96-1.26 (m, 5H), 1.55-1.72 (m, 5H), 1.80 (m, IH), 3.27 (t, 2H), 3.63 (m, 4H), 6.98 (d, IH), 7.15-7.25 (m, 3H), 7.30 (t, 3H), 7.40 (d, 2H), 7.55 (d, 2H), 7.88 (dd, IH), 7.93 (d, 2H), 8.51 (d, IH), 8.51 (t, IH), 10.89 (s, IH). Example 224 tert-butvU5R -5-((4-((((4'-(2-(( ' 2-(dimethylamino ethvP(methypamino ethyl)-2'-methoxy- l,r-biphenyl-4-ypcarbonvPamino)sulfonyl)-2-nitrophenypamino)-6- (phenylthio)hexylcarbamate The desired product was prepared by substituting Example 124C and Example 191C for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 861 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.32 (s, 9H), 2.37 (s, 3H), 2.52 (s, 6H), 2.54 (m, 6H), 2.72 (t, 2H), 2.80 (d, 2H); 2.88 (d, 2H), 3.02 (m, 2H), 3.27 (m, 4H), 3.77 (s, 3H), 3.98 (m, IH), 6.70 (m, IH), 6.89 (d, IH), 6.90 (s, IH), 6.99 (d, IH), 7.18 (m, IH), 7.22 (m, 2H), 7.30 (d, 2H), 7.39 (t, 2H), 7.81 (d, IH), 7.89 (d, 2H), 8.14 (d, IH), 8.47 (d, IH). Example 225 N-(4-(l-cyclopentyl-2-oxo-2,3-dmydro-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 225A 4-(l-cyclopentyl-2-oxo-2.3-dihydro-lH-benzimidazol-5-ypbenzoic acid The desired product was prepared by substituting cyclopentylamine for butylamine in Examples 166A, 166B, 166C, and 166D. Example 225B N-(4-(l-cyclopentyl-2-oxo-2,3-d ydro-lH-benzimidazol-5-yPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 225A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m e 656 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.68 (m, 2H), 1.91 (m, 4H), 2.05 (m, 2H), 3.28 (t, 2H), 3.62 (dt, 2H), 4.74 (m, IH), 7.03 (d, IH), 7.15-7.25 (m, 3H), 7.27-7.35 (m, 3H), 7.39 (d, 2H), 7.57 (d, 2H), 7.89 (dd, IH), 7.94 (d, 2H), 8.52 (d, IH), 8.56 (t, IH), 10.95 (s, IH). Example 226 3-nitro-N-(4-(4-(3-oxopropyPpiperidin-l-yPbenzoyl)-4-((2- (phenyltMo)ethyl)amino)benzenesulfonamide A solution of Example 203C (250mg, 0.4 mmol), in dichloromethane (5 mL), TFA (1.5 mL), and 1 drop water was stirred at room temperature for 48 hours. The reaction mixture was dUuted with dichloromethane, washed sequentially with water, saturated NaHCO 3 , and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with dichloromethane 0.5-1.0% methanol to provide the desired product. MS (APCI) m/e 597 (M+H) + ; 1H NMR (300 MHz, CDC1 3 ) δ 9.80 (s, IH), 8.87 (d, IH), 8.67 (t, IH), 8.47 (s, IH), 8.15 (dd, IH), 7.63 (d, 2H), 7.40 (m, 2H), 7.24-7.34 (m, 4H), 6.87 (d, 2H), 6.82 (m, 2H), 3.87 (d, 2H), 3.58 (m, 4H), 3.21 (t, 2H), 2.86 (m, 2H), 2.50 (m, 2H), 1.80 (m, 2H), 1.62 (m, 2H), 1.55 (s, 4H) 1.31 (m, 2H). Example 227 N-(4-(3-butyl-2-oxo-2,3-dihydro-l,3-benzox-ιzol-6-yl)benzoyp-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting 1-bromobutane for bromomethylcyclohexane in Example 181. MS (ESI) m/e 645, 647 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 0.92 (t, 3H), 1.33 (qt, 2H), 1.69 (tt, 2H), 3.26 (t, 2H), 3.62 (dt, 2H), 3.85 (t, 2H), 7.05 (d, IH), 7.19 (tt, IH), 7.29 (t, 2H), 7.39 (d, 3H), 7.58 (dd, IH), 7.68 (d, 2H), 7.73 (d, IH), 7.89 (dd, IH), 7.94 (d, 2H), 8.54 (d, IH), 8.59 (t, IH). Example 228 3-nitro-N-(4-(2-nonyl-1.3-benzothiazol-5-vPbenzovP-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting 1-bromooctane for ahyl bromide in Example 213. MS (ESI) m e 715, 717 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ.0.85 (t, 3H), 1.12-1.43 (m, 12H), 1.82 (tt, 2H), 3.12 (t, 2H), 3.28 (t, 2H), 3.61 (dt, 2H), 7.02 (d, IH), 7.19 (t, IH), 7.30 (t, 2H), 7.39 (d, 2H), 7.73 (d, 2H), 7.88 (d, IH), 7.98 (d, 2H), 8.11 (d, IH), 8.21 (s, IH), 8.53 (d, IH), 8.55 (t, IH). Example 229 N-((4'-(3-(4-(2,2-dimethylpropanoyl)piperazin- 1 -yl)propyl)-2'-methoxy- 1 , 1 '-biphenyl-4- yPcarbonyl)-3-nitro-4-((2-(phenyltMo)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting pivaloyl chloride for dimethylcai-bamic chloride in Example 200. MS (ESI(-)) m/e 772 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 1.18 (s, 9H), 1.79 (m, 2H), 2.35 (m, 6H), 2.62 (t, 2H), 3.28 (t, 2H), 3.54 (m, 4H), 3.60 (dd, 2H), 3.75 (s, 3H), 6.86 (d, IH), 6.94 (s, IH), 6.98 (d, IH), 7.18 (d, IH), 7.20 (m, IH), 7.31 (t, 2H), 7.40 (t, 4H), 7.88 (d, IH), 7.89 (d, 2H), 8.49 (d, IH), 8.51 (t, IH). Example 230 N-(4-(3-methoxycyclohept- 1 -en- 1 -yPbenzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide and N-(4-(6-methoxy cy clohept- 1 -en- 1 - yl)benzoyP-3-nitro-4-((2-(phenylthio)ethyl)amino)ben zenesulfonamide , Example 230A 3 -methoxycyclohept- 1 -en- 1 -yl trifluoroacetate and 6-methoxy cy clohept- 1 -en- 1 -yl trifluoroacetate The desired product was prepared by substituting 3-methoxycycloheptanone for 4- tert-butylcyclohexanone in Example 5A. Example 230B methyl 4-(3-methoxycyclohept-l-en-l-yl)benzoate and methyl 4-(6-methoxycyclohept-l-en- 1 -ypbenzoate The desired product was prepared by substituting Example 230A for Example 5 A in Example 5B. MS (DCI (+)) m/e 261 (M+H) + . Example 23 PC N-(4-(3 -methoxycyclohept- 1 -en- 1 -yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide and N-(4-(6-methoxycy clohept- 1 -en- 1- yl)benzoyl)-3-nitro-4-((2-(phenylthio)ethyl)amino)ben zenesulfonamide A mixture of Example 230B (70mg, 0.27mmol) and LiOH (14mg, 0.32 mmol) in THF (3 mL), methanol (1.5 mL), and water (0.5 mL) was heated to 50 °C for 3 hour and concentrated. The concentrate was dissolved in DMF (0.5 mL) and treated with a mixture of Example 77B (38 mg, 0.104 mmol), EDCI (50 mg, 0.26 mmol), and DMAP (79 mg, 0.65 mmol) in dichloroethane (0.5 mL). The mixture was stirred for 16 hours, dUuted with ethyl acetate (50 mL), washed sequentiaUy with IN HCl (5 mL), water (30 mL) and brine (30 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5% methanol/dichloromethane to provide the desired product. MS (ESI(-)) m/e 580 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.40-7.15 (m, 8H), 6.30 and 6.10 (t, IH), 4.00 and 3.70 (m, 2H), 2.90 and 2.75 (s, 3H), 2.30-1.55 (m, 1 IH). Example 231 tert-butvπ5R)-5-((4-(((4-π-benzyl-2-oxo-2.3-dihvdro-lH-benzimidazol-5- yl)benzoyPamino)sulfonyP-2-nitrophenyPamino)-6-(phenylthio)hexylcarbamate Example 231 A 4-( 1 -benzyl-2-oxo-2,3-dihvdro- 1 H-benzimidazol-5-yl)benzoic acid The desired product was prepared by substituting benzylamine for n-butylamine in Examples 166A, 166B, 166C, and 166D. Example 23 IB tert-butyl (5R)-5-((4-(((4-( 1 -benzyl-2-oxo-2,3-dihydro- 1 H-benzimidazol-5- yPbenzoyl)amino)sulfonvP-2-nitrophenvPamino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 231A and Example 124C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 849 (M-H) " ; J H NMR (300 MHz, DMSO-d 6 ) δ. 1.32 (m, HH), 1.54 (m, 2H), 1.72 (m, 2H), 2.87 (m, 2.87H), 3.98 (t, 2H), 4.12 (m, IH), 5.02 (d, 2H), 6.72 (t, 2H), 7.01 (d, IH), 7.07-7.23 (m, 4H), 7.26-7.38 (m, 8H), 7.60 (d, 2H), 7.84 (dd, IH), 7.94 (d, 2H), 8.20 (m, 2H), 8.49 (d, IH), 11.08 (s, lH). Example 232 N-(4-(4-(3 -hydroxypropyPpiperidin- 1 -yPbenzoyl) -3 -nitro-4-((2- (phenylthio)ethvPamino)benzenesulfonamide A solution of Example 226 (15 mg, 0.025 mmol) in methanol (0.5 mL) and dichloromethane (2 drops) at 0 °C was treated with NaBE- 4 (24mg, 0.6 mmol), stirred for 1 hou, warmed to room temperature, and stirred for 90 minutes. The mixture was treated with water and filtered. The filter cake was treated with dichloromethane (5 mL) and methanol (1 drop), stirred for 2 hours, and filtered. The filter cake was washed with diethyl ether, and dried under vacuum to provide the desired product. MS(ESI(-)) m/e 597 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.49 (d, IH), 8.45 (d, IH), 7.85 (dd, IH), 7.71 (d, 2H), 7.40 (m, 2H), 7.30 (m, 2H), 7.20 (m, 2H), 6.95 (d, IH), 6.90 (d, 2H), 4.34 (t, IH), 3.75 (m, 2H), 3.60 (m, 2H), 3.39 (m, 2H), 3.25 (m, 2H), 2.65 (m, 2H), 1.71 (m, 2H), 1.45 (m, 2H), 1.25-1.11 (m, 4H). Example 233 N-t2-rdimethylamino ethyP-3-(2-methoxy-4'-((((4-(((lR -2-morphoHn-4-yl-l- ((phenylt o)methvPethyl)arnino)-3-nitrophenyl)sulfonyl)amino)carbonyl)-l,r-biphenyl-4- vP-N-methylpropanamide The desired product was prepared by substituting Example 146C and Example 178B for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 817 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.18 (dd, 2H), 2.21 (s, 6H), 2.32 (dd, 2H), 2.50 (dd, 2H), 2.62 (m, 2H), 2.82 (dd, 2H), 2.94 (s, 3H), 2.98 (m, 4H), 3.34 (m, 4H), 3.52 (dd, 2H), 3.74 (s, 3H), 4.14 (m, IH), .88 (d, IH), 6.94 (s, IH), 6.98 (d, IH), 7.18 (d, IH), 7.24 (m, IH), 7.34 (t, 2H), 7.39 (t, 2H), 7.82 (d, IH), 7.89 (d, 2H), 8.32 (d, IH), 8.46 (d, IH). Example 234 N,N-bis(2-methoxyethyl)-3-(8-(4-((((3-nitro-4-((2- (phenylthio) ethyPamino phenyp sulfonyl) amino) carbonypphenyp quinolin-5-yl)propanamide The desired product was prepared by substituting bis(2-methoxyethyl)amine for 1- methylpiperazine in Example 201. MS (ESI) m e 770, 772 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 2.79 (t, 2H), 3.16 (s, 3H), 3.22 (s, 3H), 3.28 (t, 2H), 3.32 (t, 2H), 3.38 (m, 4H), 3.45 (m, 4H), 3.62 (dt, 2H), 7.02 (d, IH), 7.20 (t, IH), 7.30 (t, 2H), 7.40 (d, 2H), 7.52- 7.61 (m, 4H), 7.67 (d, IH), 7.89 (dd, IH), 7.95 (d, 2H), 8.52-8.58 (m, 3H), 8.88 (dd, IH). Example 235 tert-butyl 2-(4-(4-((((3-nitro-4-(;(;2- (phenyltMo)ethyl)amino)phenyl)sulfonyl)ammo)carbonyl)phenyl)piperazin-l- yl) ethylcarbamate The desired product was prepared by substituting (2-oxo-ethyl)-carbamic acid tert- butyl ester for (l-benzyl-2-oxo-ethyl)-carbamic acid tert-butyl ester in Example 173B. MS (ESI(-)) m/e 683 (M-H) " ; 1H NMR (300 MHz, DMSO-d6) δ 8.63 (t, IH), 8.53 (d, IH), 7.88 (dd, IH), 7.74 (d, 2H), 7.38 (d, 2H), 7.25-7.31 (m, 2H), 7.15-7.21 (m, IH), 7.08 (d, IH), 6.89 (d, 2H), 6.74 (br s, IH), 3.63 (q, 2H), 3.22-3.31 (m, lOH), 3.08-3.17 (m, 2H), 2.60-2.74 (m, 2H), 1.38 (s, 9H). Example 236 3-(4'-((((4-((;( iR)-2-((2-(dimethylamino)ethvP(;methyPamino)-l- ((phenylthio)methyPethyl)amino)-3-nitrophenyPsulfonyl)amino)carbonyl)-2-methoxy- 1,1'- biphenyl-4-yP-N,N-dimethylpropanamide Example 236A 4'-(3-(dimethylamino)-3-oxopropyl)-2'-methoxy-l , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 427A for Example 1 A in Example IB. Example 236B 3-(4'-((((4-(((lR)-2-((2-(dimethylamino)ethvP(;methvPamino -l- ((phenylthio)methyl)ethyl)amino)-3-nitrophenyPsulfonyPamino)carbonyl)-2-methoxy-l , 1 '- biphenyl-4-yP-N,N-dimethylpropanamide The desired product was prepared by substituting Example 236A and Example 206C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 775 (M-H) " ; ! H NMR (300 MHz, DMSO-d 6 ) δ 1.18 (s, 9H), 1.79 (m, 2H), 2.35 (m, 6H), 2.62 (t, 2H), 3.28 (t, 2H), 3.54 (m, 4H), 3.60 (dd, 2H), 3.75 (s, 3H), 6.88 (d, IH), 6.94 (s, IH), 6.98 (d, IH), 7.18 (d, IH), 7.23 (m, IH), 7.32 (t, 2H), 7.39 (d, 2H), 7.82 (d, IH), 7.89 (d, 2H), 8.20 (d, 2H), 8.48 (d, IH). Example 237 N-((2'-methoxy-4'-(3-(4-(methoxyacetyPpiperazin- 1 -yppropyp- 1 , 1 '-biphenyl-4-ypcarbonyP- 3-nitro-4-((2-(phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting methoxyacetyl chloride for dimethylcarbamic chloride in Example 200. MS (ESI(-)) m/e 760 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 1.80 (m, 2H), 2.42 (m, 4H), 2.62 (t, 2H), 3.26 (m, 4H), 3.28 (s, 3H), 3.40 (m, 4H), 3.48 (m, 2H), 3.60 (dd, 2H), 3.75 (s, 3H), 4.08 (s, 2H), 6.86 (d, IH), 6.95 (s, IH), 6.99 (d, IH), 7.18 (d, IH), 7.20 (dd, IH), 7.31 (t, 2H), 7.40 (t, 4H), 7.88 (d, IH), 7.89 (d, 2H), 8.49 (d, IH), 8.51 (t, IH). Example 238 N-((2'-methoxy-4'-(3-(4-(methylsulfonyl)piperazin- 1 -yppropyp- 1 , 1 '-biphenyl-4- yl)c-ιrbonyP-3-nitro-4-((2-(phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting methanesulfonyl chloride for dimethylcarbamic chloride in Example 200. MS (ESI(-)) m/e 766 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 1.99 (m, 2H), 2.68 (m, 4H), 2.86 (s, 3H), 2.96 (m, 4H), 3.08 (m, 4H), 3.30 (m, 4H), 3.77 (s, 3H), 4.08 (m, IH), 6.91 (d, IH), 6.99 (s, IH), 7.18 (m, IH), 7.22 (dd, IH), 7.28 (m, 3H), 7.38 (d, 2H), 7.52 (d, 2H), 7.89 (d, 2H), 8.58 (d, IH), 8.62 (t, IH). Example 239 N-(4-(3 , 3 -dimethylpip eridin- 1 -yl)benzoyl)-3 -nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 239A ethyl 4-(3 ,3 -dimethyl-2,6-dioxopiperidin- 1 -ypbenzoate The desired product was prepared by substituting 2,2-dimethylglutaric anhydride for 3,3-dimethylglutaric anhydride in Example 119A. MS (DCI) m/e 307 (M+NHt) " . Example 239B ethyl 4-(3,3-dimethylpiperidin-l-yl)benzoate The desired product was prepared by substituting Example 239A for Example 119A in Example 119B. MS (DCI) m/e 262 (M+H) + . Example 239C 4-(3,3-dimethylpiperidin-l-yl)benzoic acid The desired product was prepared by substituting Example 239B for Example 119B in Example 119C. MS (DCI) m/e 234 (M+H) + . Example 239D N-(4-(3,3-dimethylpiperidin-l-yPbenzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 239C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 567 (M-H) " ; ! H NMR (300 MHz, DMSO-d 6 ) δ 11.92 (s, IH), 8.77 (t, IH), 8.60 (d, IH), 7.90 (dd, IH), 7.70 (d, 2H), 7.37 (d, 2H), 7.26 (t, 2H), 7.18 (m, 2H), 6.89 (d, 2H), 3.67 (m, 2H), 3.30 (m, 4H), 3.09 (s, 2H), 1.59 (m, 2H), 1.38 (t, 2H), 0.89 (s, 6H). Example 240 4-(((lR)-2-(dimethylamino)-l-((phenylthio)methyl)ethyl)amino)-N-((2'-methoxy-4'-(3- morphoHn-4-yl-3-oxopropyl)-l,r-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide Example 240A 2'-methoxy-4'-(3-morphoHn-4-yl-3-oxopropyP- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 122M for Example 1A in Example IB. Example 240B 4-(((lR)-2-(dimethylamino)-l-((phenylthio)methyl)ethyl)amino)-N-((2'-methoxy-4'-(3- moφhoHn-4-yl-3-oxopropyl)-l,r-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 240A and Example 134D for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m e 760 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 2.61 (m, 2H), 2.66 (t, 2H), 2.84 (t, 2H), 3.31 (dd, IH), 3.32 (s, 6H), 3.37 (dd, IH), 3.44 (m, 4H), 3.52 (m, 4H), 3.74 (s, 3H), 4.12 (m, IH), 6.89 (d, IH), 6.94 (d, IH), 6.99 (s, IH), 7.16 (d, IH), 7.20 (dd, IH), 7.22 (dd, 2H), 7.31 (d, 2H), 7.38 (d, 2H), 7.81 (d, IH), 7.89 (d, 2H), 8.24 (d, IH), 8.44 (d, IH). Example 241 4-((3-(dimethylamino)-2-(phenylthio)propyPamino)-N-((4'-fluoro- 1 , 1 '-biphenyl-4- yPcarbonyP-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 212C for Example IC in Example ID. MS (ESI(-)) m/e 607 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.80 (t, IH), 8.52 (d, IH), 7.93 (d, 2H), 7.87 (dd, IH), 7.76-7.70 (m, 2H), 7.60 (d, 2H), 7.51-7.47 (m, 2H), 7.35-7.25 (m, 5H), 6.95 (d, IH), 3.82-3.75 (m,' IH), 3.62-3.50 (m, 2H), 2.86-2.62 (m, 2H), 2.41 (br s, 6H). Example 242 N-((2'-methoxy-4'-(2-(4-methylpiperazin-l-ypethyp-l i r-biphenyl-4-yPcarbonyP-3-nitro-4- ((2-(phenylthio)ethyl)amino)benzenesulfonamide Example 242A methyl 2 '-methoxy-4'-(2-(4-methylpiperazin- 1 -y ethyl)- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting N-methylpiperidine and Example 191 A for dimethylamine and Example 134A, respectively, in Example 134B. MS (ESI(+)) m/e 369 (M+H) + . Example 242B 2'-methoxy-4'-(2-(4-methylpiperazin- 1 -yPethyP- 1.1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 242A for Example 1 A in Example IB. MS (ESI(-)) m/e 353 (M-H) " . Example 242C N-((2'-methoxy-4'-(2-(4-methylpiperazin-l-yl)ethyP-l,r-biphenyl-4-ypcarbonyl)-3-nitro-4- ((2-(phenylthio) ethyl) aminolbenzenesulfonamide The desired product was prepared by substituting Example 242B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 688 (M-H) " ; ! H NMR (300 MHz, DMSO-d 6 ) δ 2.58 (s, 3H), 2.82 (m, 2H), 3.40 (m, 4H), 2.98 (m, 6H), 3.15 (d, 2H), 3.28 (dd, 2H), 3.76 (s, 3H), 4.05 (dd, IH), 6.91 (d, IH), 6.99 (d, IH), 7.00 (s, IH), 7.18 (d, IH), 7.20 (dd, IH), 7.32 (t, 2H), 7.40 (t, 4H), 7.90 (m, 2H), 8.49 (t, IH), 8.51 (d, IH). Example 243 3-nitro-N-(4-(5-(3-oxo-3-piperidin-l-ylpropyl)quinolin-8-yl)benzoyl)-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting piperidine for 1-methylpiperazine in Example 201. . MS (ESI) m/e 722, 724 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.35 (m, 4H), 1.52 (m, 2H), 2.74 (t, 2H), 3.27 (t, 2H), 3.29 (t, 2H)* 3.35 (t, 2H), 3.43 (t, 2H) 3.61 (dt, 2H), 6.99 (d, IH), 7.20 (tt, IH), 7.31 (td, 2H), 7.40 (dd, 2H), 7.52-7.60 (m, 4H), 7.67 (d, IH), 7.89 (dd, IH), 7.95 (d, 2H), 8.51 (t, IH), 8.52 (d, IH), 8.56 (dd, IH), 8.88 (dd, IH). Example 244 N-(2-(dimethylamino ethvP-3-(8-(4-((((3-nitro-4-((2- (phenylthio)ethyl) amino phenyl) sulfonyl) amino) carbonypphenyp quinolin-5-yl)propanamide The desired product was prepared by substituting N,N-dimethylethylenediamine for 1-methylpiperazine in Example 201. MS (ESI) m/e 725, 727 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 2.56 (t, 2H), 2.68 (s, 6H), 2.97 (t, 2H), 3.08 (q, 2H), 3.27 (t, 2H), 3.36 (t, 2H), 3.61 (dt, 2H), 7.00 (d, IH), 7.20 (tt, IH), 7.31 (t, 2H), 7.40 (d, 2H), 7.51 (d, IH), 7.57 (d, 2H), 7.60 (dd, IH), 7.68 (d, IH), 7.89 (dd, IH), 7.96 (d, 2H), 8.11 (t, IH), 8.52 (t, IH), 8.53 (d, IH), 8.58 (dd, IH), 8.90 (dd, IH). Example 245 N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl) carbonyP-4-((2-morphoHn-4-yl- 1 - ((phenylthio)methyl)ethyl)amino)-3-nitrobenzenesulfonamide Example 245A 4-((2-morphoUn-4-yl-l-((phenyltMo)methyl)ethyl)amino -3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 180B for Example 122F in Example 122G. MS (ESI(+)) m/e 453 (M+H) + . Example 245B N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl) carbonyP-4-((2-morphohn-4-yl- 1 - ((phenylthio)methyl) ethyl) amino) -3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 245A for Example IC in Example ID. MS (ESI(-)) m/e 649 (M-H) " ; ! H NMR (400 MHz, DMSO-d 6 ) δ 8.55 (d, IH), 8.45 (d, IH), 7.97 (d, 2H), 7.88 (dd, IH), 7.75 (m, 5H), 7.30 (m, 4H), 7.15 (m, 3H), 4.30 (m, IH), 3.55 (t, 4H), 3.42 (dd, IH), 3.31 (dd, IH), another 4 protons were buried under solvent peaks. Example 246 3-r2-methoxy-4'-((((4-(((lR)-2-morphohn-4-yl-l-f(phenylthio)methyPethyl)amino -3- nitrophenyl)sulfonypamino)carbonyP- 1 , 1 '-biphenyl-4-yl)-N,N-dimethylpropanamide The desired product was prepared by substituting Example 236A and Example 146C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 760 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.36 (t, 2H), 2.44 (t, 2H), 2.62 (dd, 4H), 2.81 (dd, 2H), 2.82 (s, 3H), 2.96 (s, 3H), 3.31 (m, IH), 3.41 (dd, IH), 3.52 (dd, 4H), 3.74 (s, 3H), 4.15 (m, IH), 6.89 (d, IH), 6.94 (d, IH), 6.99 (s, IH), 7.18 (d, IH), 7.20 (dd, IH), 7.32 (t, 2H), 7.45 (m, 4H), 7.81 (dd, IH), 7.89 (d, 2H), 8.32 (d, IH), 8.48 (d, IH). Example 247 N-(4-(3,3-dimethylpyrroHdin-l-vPbenzoyP-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 247A methyl 4-(3 ,3 -dimethyl-2,5-dioxopyrroUdin- 1 -ypbenzoate The desired product was prepared by substituting methyl 4-aminobenzoate and 2,2- dimethylsuccinic anhydride for ethyl 4-aminobenzoate and 3,3-dimethylglutaric anhydride, respectively, in Example 119A. MS (DCI) m/e 262 (M+H) + . Example 247B methyl 4-(3 ,3-dimethylpyrroHdin- 1 -ypbenzoate The desired product was prepared by substituting Example 247A for Example 119A in Example 119B. MS (DCI) m/e 234 (M+H) + . Example 247C 4-(3 ,3-dimethylpyrroHdin- 1 -ypbenzoic acid The desired product was prepared by substituting Example 247B for Example 119B in Example 119C. MS (DCI) m/e 220 (M+H) + . Example 247D N-(4-(3,3-dimethylpyrroHdin-l-yPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyl)ammo)benzenesulfonamide The desired product was prepared by substituting Example 247C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m e 553 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.87 (s, IH), 8.76 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.72 (d, 2H), 7.37 (d, 2H), 7.26 (t, 2H), 7.18 (m, 2H), 6.50 (d, 2H), 3.67 (m, 2H), 3.38 (t, 2H), 3.30 (m, 2H), 3.07 (s, 2H), 1.77 (t, 2H), 1.09 (s, 6H). Example 248 N-((2'-methoxy-4 '-(3 -(4-methylpiperazin- 1 -yPpropyP- 1 , 1 '-bipheny 1-4-yl) carbonyl) -3 -nitro-4- ((2-(phenylthio)ethyl)amino)benzenesulfonamide Example 248A methyl 2'-methoxy-4'-(3 -(4-methylpiperazin- 1 -yppropyp- 1 , 1 '-biphenyl-4-carboxylate A solution of Example 362A (1.00 g, 2.52 mmol) in THF (5 mL) at room temperature was slowly treated with IM BH 3 in THF (7.57 mL, 7.57 mmol), stirred for 16 hours, quenched with methanol (30 mL) and water (5 mL), treated with concentrated HCl (1 mL), heated to 60 °C, and stirred for 2 hours. The mixture was treated with IM NaOH (50 mL) and extracted with 80:20:0.5 dichloromethane/methanol/concentrated ammonium hydroxide (3 x 250 mL). The combined extracts were washed with brine (50 mL), and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 80:20:0.5 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired ■ product. Example 248B 2'-methoxy-4'-(3 -(4-methylpiperazin- 1 -yppropyp- 1.1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 248A for Example 1 A in Example IB. Example 248C N-((2'-methoxy-4'-(3-(4-methylpiperazin-l-yl)propyP-l,r-biphenyl-4-yl)carbonyP-3-nitro-4- ((2-(phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 248B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 702, 704 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.87 (m, 2H), 2.23 (s, 3H), 2.57 (m, 8H), 2.63 (t, 2H), 3.06 (q, 2H), 3.26 (t, 2H), 3.60 (dt, 2H), 3.75 (s, 3H), 6.87 (d, IH), 6.95 (s, IH), 7.00 (d, IH), 7.19 (tt, IH), 7.21 (d, 2H), 7.30 (td, 2H), 7.47-7.53 (m, 3H), 7.88 (d, 3H), 8.50 (d, IH), 8.53 (d, IH). Example 249 3-nitro-4-((2-(phenylthio)ethyPamino)-N-(4-(thien-3- ylmethoxy)benzoyl)benzenesulfonamide The desired product was prepared by substituting 3-thiophenemethanol for 4- butylbenzyl alcohol in Example 209. MS (ESI) m/e 568, 570 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 3.27 (t, 2H), 3.62 (dt, 2H), 5.12 (s, 2H), 6.97 (d, 2H), 7.06 (d, IH), 7.18 (t, 2H), 7.28 (t, 2H), 7.38 (d, 2H), 7.54 (dd, IH), 7.58 (s, IH), 7.83 (d, 2H), 7.87 (dd, IH), 8.54 (d, IH), 8.62 (t, IH). Example 250 N-(4-(4-(3-(4-methylpiperidin- 1 -yppropyppiperidin- 1 -yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide A solution Example 226 (20 mg, 0.03 mmol) and 4-methylpiperidine (0.02 mL, 0.17 mmol), and methanol (0.4 mL) at room temperature was treated with NaCNBH 3 (5.5 mg, 0.08 mmol) and acetic acid (1 drop), stirred for 18 hours, diluted with dichloromethane, washed with saturated NaHCO 3 and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by reverse phase chromatography, eluting with 0-100% CH 3 CN/water containing 0.1% TFA to provide the desired product. MS (ESI) m e 678 (M- H) ' ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.87 (s, IH), 8.79 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.72 (d, 2H), 7.35 (d, 2H), 7.28-7.15 (m, 4H), 6.93 (d, 2H), 3.67 (m, 2H), 3.38 (t, 2H), 3.29 (m, 2H), 2.28 (m, IH), 1.85-1.60 (m, 8H), 1.36-1.00 (m, 6H), 0.92 (d, 3H). Example 251 3-nitro-N-(4-(2-oxo-2,3-dihydro-l,3-benzoxazol-6-yl)benzoyl)-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 251 A 6-bromo-l .3-benzoxazol-2(3H)-one A mixture of 2-benzoxazolinone (3.00 g, 22.2 mmol), l,3-dibromo-5,5- dimethylhydantoin (3.49 g, 12.2 mmol), and trifluoromethanesulfonic acid (5.00 g, 33.3 mmol) in dichloromethane (100 mL) at room temperature was protected from Hght, stirred for 1 hour, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 50% ethyl acetate/hexanes to provide the desired product. Example 25 IB methyl 4-(2-oxo-2,3-dihydro-l ,3-benzoxazol-6-yPbenzoate The desired product was prepared by substituting Example 251 A for Example 5A in Example 5B. Example 25 IC 4-(2-oxo-2.3-dihydro-l,3-benzoxazol~6~yl)benzoic acid The desired product was prepared by substituting Example 251B for Example 1 A in Example IB. Example 25 ID 3-rntJO-N-(4-(2-oxo-2,3-dihvdro-1.3-berizoxazol-6-yl)benzoyP-4-((2- (phenylthio) ethyl) amino benzenesulfonamide The desired product was prepared by substituting Example 251 C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 589 (M-H) " ; l H NMR (300 MHz, DMSO-de) δ .3.27 (t, 2H), 3.61 (dt, 2H), 7.01 (d, IH), 7.15 (d, IH), 7.18 (tt, IH), 7.29 (td, 2H), 7.39 (d, 2H), 7.48 (dd, IH), 7.62 (d, 2H), 7.65 (d, IH), 7.89 (dd, IH), 7.94 (d, 2H), 8.52 (d, IH), 8.53 (t, IH), 11.70 (s, IH). Example 252 N-(4-(6-chloropyridin-3-yl)benzovP-3-nitro-4-(((4-(phenylthio)piperidin-4- ypmethvPamino)benzenesulfonamide Example 252A tert-butyl 4-cyano-4-(phenylthio)piperidine- 1 -carboxylate A solution of dnsopropylamine (3.36 mL, 24 mmol) in THF (20 mL) at -78 °C was slowly treated with 2.5M n-butyUithium (7.2 mL, 18 mmol) in hexanes, warmed to 0 °C for 15 minutes, cooled to -78 °C, treated slowly with a solution of N-BOC-4-cyanopiperidine (2.5g, 12 mmol) in THF (10 mL), stirred for 30 minutes, and treated with a solution of PhSSPh (5.24g, 24mmol) in THF (20 mL). The mixture was stirred for 2 hours, warmed to room temperature, and quenched with saturated NH 4 CI (50 mL). The mixture was extracted with ethyl acetate (3 x 50 mL) and the combined extracts were washed with water and brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 3 : 1 hexanes/ethyl acetate to provide the desired product. MS (ESI) m/e 319 (M+H) + . Example 252B tert-butyl 4-(aminomethyl)-4-(phenylthio)piperidine- 1 -carboxylate A solution of Example 252A (1.0g, 3. lmmol) in THF (5 mL) at 0 °C was treated dropwise with IM L-AIH 4 in THF (3 mL), warmed to room temperature, stirred for 2 hours, quenched with methanol (1 mL), treated with IN NaOH (50 mL), and extracted with ethyl acetate(3 x 100 mL). The combined extracts were washed with water and brine, dried (Na 2 SO 4 ), fUtered, and concentrated to provide the desired product. MS (APCI) m/e 323(M+H) + . Example 252C tert-butyl 4-(((4-(armnosulfonyp-2-nitrophenyl)amino)methyP-4-(phenylthio)piperidine- 1 - carboxylate A mixture of Example 252B (1.0 g, 3.1 mmol), Example 122C (0.683 g, 3.1 mmol), and dnsopropylethylamine (2 mL) in DMSO (10 mL) was heated to 50 °C for 18 hours, dUuted with ethyl acetate (100 mL), washed with water and brine,dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 1 : 1 hexanes/ethyl acetate to provide the desiredproduct. MS (ESI(-)) m/e 521 (M- H) " . Example 252D methyl 4-(6-methoxypyridin-3-ypbenzoate A mixture of 5-bromo-2-methoxypyridine (2.93 g, 10 mmol), 4- methylcarboxybenzeneboronic acid (1.80g, lOmmol), Pd(Pli 3 P) 4 (0.346 g, 0.3 mmol) and CsF (1.52 g, 10 mmol) in DME (60 mL) and methanol (30 mL) was heated to reflux for 18 hours and concentrated. The concentrate was dissolved in water (50 mL) and ethyl acetate (300 mL) and the organic phase was washed with water (2 x 50 mL) and brine (50 mL), dried filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 3: 1 hexanes/ethyl acetate to provide the desired product. MS (APCI) m/e 278, 280 (M-H) " , (M+H) + . Example 252E methyl 4-(6-hydroxypyridin-3 -ypbenzoate A solution of Example 252D (0.5 g, 2.2 mmol) in dichloromethane at -78 °C was treated with IM BBr 3 in dichloromethane (15 mL), warm to room temperature, and stirred for 18 hours. The reaction was quenched with methanol (5 mL), dUuted with dichloromethane (100 mL), washed with water (30 mL), brine (30 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 2: 1 hexanes/ethyl acetate to provide the desired product. MS (ESI) m e 228, 230 (M-H) " , (M+H) + . Example 252F methyl 4-(6-chloropyridin-3 -ypbenzoate A solution of Example 252E (1.2 g, 5 mmol) in POCI 3 (30 mL) was heated to reflux for 30 minutes. The excess POCI 3 was removed under vacuum and the remaining product was purified by flash column chromatography on silica gel with 4: 1 ethyl acetate/hexanes to provide the desired product. MS (ESI) m/e 248 (M+H) + . Example 252G 4-(6-chloropyridin-3-yl)benzoic acid A solution of Example 252F (1.56 g, 6.4 mmol) in THF (30 mL) at room temperature ws treated with a solution of LiOH H 2 θ (0.537g, 12.8mmol) in water (5 mL), heated to reflux for 4 hours, cooled to room temperature and concentrated. The mixture was neutralized with IN HCl and extracted ethyl acetate (3 x 50 mL). The combined extracts were washed with brine, dried (Na 2 SO 4 ), filtered, and concentrated to provide the desired product. MS (APCI) m/e 234 (M+H) + . Example 252H N-(4-(6-chloropyridin-3-yl)benzoyl)-3-nitro-4-(((4-(phenylthio)piperidin-4- vPmethvPamino)benzenesulfonamide The desired product was prepared by substituting Example 252C and Example 252G for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI(-)) m/e 636 (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 9.10 (m, IH), 8.98 (t, IH), 8.93 (m, IH), 8.81 (dd, IH), 8.74 (d, IH), 8.24 (dd, IH), 8.01 (d, 2H), 7.90 (d, 2H), 7.64 (d, IH), 7.54 (dt, 2H), 7.48 (tt, IH), 7.41 (td, 2H), 7.33 (d, IH), 3.40 (d, 2H), 3.23 (m, 4H), 1.97-1.82 (m, 4H). Example 253 3-m-tro-4-(((4-(phenyltMo)piperidin-4-yl)methyPamino)-N-(4-(5-(trifluoromethyl)pyridin-2- yPbenzoyPbenzenesulfonamide Example 253A methyl 4-(5-(trifluoromethyPpyridin-2-yPbenzoate The desired product was prepared by substituting 2-chloro-5-trifluoromethylpyridine for 5-bromo-2-methoxypyridine in Example 252D. MS (ESI(+)) m/e 282 (M+H) + . Example 253B 4-(5-(trifluoromethyPpyridin-2-yl)benzoic acid The desired product was prepared by substituing Example 253A for Example 252F in Example 252G. MS (ESI(+)) m/e 268 (M+H) + . Example 253 C 3-nitro-4-(((4-(phenylthio)piperidin-4-yPmethyl)amino)-N-(4-(5-(trifluoromethvPpyridin-2- ypbenzoypbenzenesulfonamide The desired product was prepared by substituting Example 252C and Example 253B for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI(-)) m/e 636 (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 9.09 (d, IH), 9.08 (m, IH), 8.98 (t, IH), 8.89 (m, IH), 8.74 (d, IH), 8.34 (dd, IH), 8.30 (d, IH), 8.29 (d, 2H), 8.04 (d, 2H), 8.01 (dd, IH), 7.54 (dt, 2H), 7.48 (tt, IH), 7.41 (td, 2H), 7.33 (d, IH), 3.40 (d, 2H), 3.23 (m, 4H), 1.97-1.82 (m, 4H). Example 254 N-(4-(5-chloropyridin-2-yPbenzoyP-3-nitro-4-(((4-(phenylthio)piperidin-4- yPmethyPamino)benzenesulfonamide Example 254A methyl 4-(5-chloropyridin-2-yl)benzoate The desired product was prepared by substituting 2,5-dichloropyridine for 5-bromo-2- methoxypyridine in Example 252D. MS (ESI(+)) m/e 248 (M+H) + . Example 254B 4-(5-chloropyridin-2-yl)benzoic acid The desired product was prepared by substituting Example 254A for Example 252F in Example 252G. MS (ESI(+)) m/e 234 (M+H) + . Example 254C N-(4-(5-chloropyridin-2-yl)benzoyl)-3-nitro-4-(((4-(phenylthio)piperidin-4- yPmethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 252C and Example 254B for 124E and 257C, respectively, in Example 124F. MS (ESI(-)) m/e 636 (M-H) " ; 1H NMR (500 MHz, DMSO-de) δ 9.05 (m, IH), 8.98 (t, IH), 8.85 (m, IH), 8.74 ( , 2H), 8.21 (d, 2H), 8.11 (d, IH), 8.06 (dd, IH), 8.00 (d, 2H), 7.54 (dt, 2H), 7.48 (tt, IH), 7.41 (td, 2H), 7.32 (d, IH), 3.40 (d, 2H), 3.23 (m, 4H), 1.97-1.82 (m, 4H). Example 255 4-((2-adamantylmethyl)amino)-3-nitro-N-(4-quinolin-8-ylbenzoyPbenzenesulfonamide Example 255A 4-((l-adamantylmethyl)amino)-3-nitro-N-(4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- ypbenzoypbenzenesulfonamide The desired product was prepared by substituting Example 28A for Example 3A in Example 3C. Example 255B 4-((2-adamantylmethyl)amino)-3-nitro-N-(4-quinolin-8-ylbenzoyPbenzenesulfonamide The desired product was prepared by substituting Example 255A and 8- bromoquinoline for Example 108A and Example 389A, respectively, in Example 389B. MS (ESI(-)) m/e 595 (M-H) " ; H NMR (300 MHz, methanol-d 4 ) δ 8.81 (m, 2H), 8.52 (7, IH), 8.39 (dd, IH), 8.16 (d, 2H), 8.03 (d, IH), 7.95 (d, IH), 7.74 (d, IH), 7.68 (d, IH), 7.63 (d, 2H), 7.52 (dd, 2H), 7.13 (d, IH), 3.12 (d, 2H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 256 N-(4-(2-methylquinolin-8-yl)benzovP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 256A 2-methylquinolin-8-yl trifluoroacetate The desired product was prepared by substituting 8-hydroxy-2-methylquinoline for vanillin in Example 122H. Example 256B N-(4-(2-methylquinolin-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 256A for Example 389A in Example 389B. MS (ESI(-)) m/e 597 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.57 (m,2H), 8.29 (d, IH), 7.94 (m, 4H), 7.72 (m, IH), 7.65 (d, 2H), 7.59 (t, IH), 7.44 (d, IH), 7.40 (m, 2H), 7.30 (t, 2H), 7.20 (tt, IH), 7.06 (d, IH), 3.63 (q, 2H), 3.26 (t, 2H), 2.59 (s, 3H). Example 257 tert-butyl (5R -5-((4-(((4-(8-azaspiro(4.5)dec-8-yPbenzoyPamino sulfonyP-2- nitrophenyPamino)-6-(phenylthio)hexylcarbamate Example 257A methyl 4-(7,9-dioxo-8-azaspiro(4.5)dec-8-yl)benzoate The desired product was prepared by substituting methyl 4-aminobenzoate and 3,3- tetramethyleneglutaric anhydride for ethyl 4-aminobenzoate and 3,3-dimethylglutaric anhydride, respectively, in Example 119A. MS (DCI) m/e 302 (M+H) + . Example 257B methyl 4-(8-azaspiro(4.5)dec-8-yl)benzoate The desired product was prepared by substituting Example 257A for Example 119A in Example 119B. MS (DCI) m/e 274 (M+H) + . Example 257C 4-(8-azaspiro(4.5)dec-8-yl)benzoic acid The desired product was prepared by substituting Example 257B for Example 119B in Example 119C. MS (DCI) m/e 260 (M+H) + . Example 257D tert-butyl (5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yl)benzoyl)amino)sulfonyP-2- nitrophenyl)amino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 257C and Example 124C for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 766; H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.52 (d, IH), 8.29 (d, IH), 7.83 (dd, IH), 7.74 (d, 2H), 7.24 (d, 2H), 7.18-7.08 (m, 4H), 6.91 (d, 2H), 6.72 (t, IH), 4.04 (s, IH), 3.98 (t, IH), 2.86 (m, 2H), 1.72 (m, 2H), 1.59 (m, 4H), 1.45 (m, 8H), 1.31 (s, 9H). Example 258 N-(4-(3-azabicvclo(3.1 ■0)hex-3-yPbenzovP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 258A methyl 4-(2,4-dioxo-3-azabicyclo(3.1.0)hex-3 -ypbenzoate The desired product was prepared by substituting methyl 4-aminobenzoate and 3- oxabicyclo(3.1.0)hexane-2,4-dione for ethyl 4-aminobenzoate and 3,3-dimethylglutaric anhydride, respectively, in Example 119A. MS (DCI) m/e 263 (M+NH- 4 ) + . Example 258B methyl 4-(3-azabicyclo(3.1 ■0)hex-3-yl)benzoate The desired product was prepared by substituting Example 258 A for Example 119A in Example 119B. MS (DCI) m/e 218 (M+H) + . Example 258C 4-(3-azabicyclo(3.1.0)hex-3-yl) benzoic acid The desired product was prepared by substituting Example 258B for Example 119B in Example 119C. MS (DCI) m/e 204 (M+H) + . Example 258D N- 4-(3-azabicvclor3.1.0)hex-3-yl)benzoyl)-3-nitro-4-( ' ( ' 2- (phenylthio)ethvPamino)benzenesulfonamide The desired product was prepared by substituting Example 258C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 561 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.91 (s, IH), 8.74 (t, IH), 8.58 (d, IH), 7.90 (dd, IH), 7.71 (d, 2H), 7.37 (d, 2H), 7.27 (t, 2H), 7.18 (m, 2H), 6.52 (d, 2H), 3.66 (m, 2H), 3.51 (d, 2H), 3.25 (m, 4H), 1.71 (m, 2H), 0.75 (m, IH), 0.18 (m, IH). Example 259 N-(4-(4-ethyl-4-methylpiperidin- 1 -vPbenzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 123C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 581 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.77 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.73 (d, 2H), 7.37 (d, 2H), 7.26 (t, 2H), 7.18 (m, 2H), 6.91 (d, 2H), 3.67 (m, 2H), 3.45 (m, 2H), 3.30 (m, 2H), 3.20 (m, 2H), 1.36 (m, 3H), 1.29 (m, 3H), 0.90 (s, 3H), 0.80 (t, 3H). Example 260 3-nitro-N-(4-(2-(2-phenylethvP-l,3-benzothiazol-5-vPbenzovP-4-((2- (phenylthio ethyl) amino)benzenesulfonamide The desired product was prepared by substituting benzyl bromide for aUyl bromide in Example 213. MS (ESI) m/e 693, 695 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 3.18 (t, 2H), 3.29 (t, 2H), 3.47 (t, 2H), 3.64 (dt, 2H), 7.11 (d, IH), 7.19 (dt, 2H), 7.25-7.34 (m, 6H), 7.39 (dd, 2H), 7.75 (dd, IH), 7.81 (d, 2H), 7.92 (dd, IH), 7.98 (d, 2H), 8.12 (d, IH), 8.26 (d, IH), 8.57 (d, IH), 8.65 (t, IH). Example 261 tert-butyl (5R)-5-((4-(((4-(4.4-dimethylpiperidin- 1 -yPbenzoyl)amino)sulfonyl)-2- nitrophenyPamino -6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 119C and Example 124C, for Example IB and Example IC, respectively, in Example ID. MS(ESI(+)) m/e 740 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.49 (d, IH), 8.23 (d, IH), 7.81 (dd, IH), 7.73 (d, 2H), 7.26 (d, 2H), 7.21-7.11 (m, 3H), 7.04 (d, IH), 6.87 (d, 2H), 6.72 (t, IH), 4.00 (m, 2H), 3.28 (m, 6H), 1.71 (m, 2H), 1.35 (m, 8H), 1.32 (s, 9H), 0.94 (s, 6H). Example 262 4-(((lR)-5-amino-l-((phenylthio)methyl)pentyl)amino)-N-((2'-methoxy-4'-(3-morphoHn-4- yl-3-oxopropyl)-l,r-biphenyl-4-yPc-irbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 122M for Example 122N in Example 194. MS (ESI(-)) m/e 774 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 12.50 (br s, IH), 8.55 (d, IH), 8.35 (br d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.70 (br s, 2H), 7.58 (d, 2H), 7.30-7.12 (m, IH), 7.00 (d, IH), 6.89 (dd, IH), 4.10 (m, IH), 3.75 (s, 3H), 3.50(m, 4H), 3.45 (m, 4H), 3.35 (m, 2H), 2.85 (t, 2H), 2.75 (m, 2H), 2.70 (t, 2H), 1.75 (m, 2H), 1.50 (m, 2H), 1.40 (m, 2H). Example 263 2-(4'-((((4-((( 1 R)-5-amino- 1 -((phenylthio)methyl)pentyl)amino)-3- nitrophenvPsulfonyPamino)carbonyP-2-methoxy- 1 , 1 '-biphenyl-4-yD-N.N- dimethylacetamide The desired product was prepared by substituting Example 441 A for Example 122N in Example 194. MS (ESI(-)) m/e M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 12.5 (br s, IH), 8.55 (d, IH), 8.35 (br d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.70 (br s, 2H), 7.58 (d, 2H), 7.25 (dd, IH), 7.20 (d, IH), 7.0-7.12 (m, 5H), 7.00 (d, IH), 6.89 (dd, IH), 4.10 (m, IH), 3.75 (s, 3H), 3.72 (s, 2H), 3.35 (m, 2H), 3.04 (s, 3H), 2.85 (s, 3H), 2.75 (m, 2H), 1.75 (m, 2H), 1.50 (m, 2H), 1.40 (m, 2H). Example 264 4-((cyclohexylmethyl)amino)-3-nitro-N-(4-quinόUn-8-ylbenzoyl)benzenesulfonamide Example 264A methyl 4-quinolin-8-ylbenzoate The desired product was prepared by substituting 8-bromoquinohne for Example 5A in Example 5B. Example 264B 4-quinoHn-8-ylbenzoic acid The desired product was prepared by substituting Example 264A for Example 1 A in Example IB. Example 264C 4-((cyclohexylmethyPamino)-3-nitro-N-(4-quinoHn-8-ylbenzoyl)benzenesulfonamide The desired product was prepared by substituting Example 264B and Example 2 IB for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 543 (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 8.91 (dd, IH), 8.53 (d, IH), 8.43 (dd, IH), 8.40 (t, IH), 8.00 (d, IH), 7.97 (d, 2H), 7.92 (dd, IH), 7.77 9dd, IH), 7.68 (t, IH), 7.60 9d, 2H), 7.56 (dd, IH), 7.08 (d, IH), 3.25 (t, 2H), 1.80-1.60 (m, 6H), 1.25-1.12 (m, 3H), 1.00 (m, 2H). Example 265 N-(4-(4-(4-fluorophenyl)piperazin-l-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethypamino)benzenesulfonamide Example 265A ethyl 4-(4-(4-fluorophenyPpiperazin- 1 -ypbenzoate The desired product was prepared by substituting 4-fluorophenyl-l-piperazine for Example 131A in Example 13 IB. MS (ESI(+)) m/e 329 (M+H) + . Example 265B 4-(4-(4-fluorophenyl)piperazin- 1 -ypbenzoic acid The desired product was prepared by substituting Example 265A for Example 13 IB in Example 13 IC. MS (ESI(-)) m/e 299 (M-H) " . Example 265C N-(4-(4-(4-fluorophenyPpiperazin- 1 -yl)benzoyl)-3 -nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 265B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 634 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 12.05 (br s, IH), 8.78 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.77 (d, 2H), 7.35-7.39 (m, 2H), 6.97-7.29 (m, 10H), 3.67(q, 2H), 3.41-3.52 (m, 4H), 3.25- 3.31 (m, 2H), 3.17-3.23 (m, 4H). Example 266 N-(4-(8-azaspiro(4.5)dec-8-yl)benzoyl)-4-((2-methyl-2-(phenylthio)propyP amino)-3 - nitrobenzenesulfonamide Example 266A 2-methyl-2-(phenylthio)propanenitrUe A solution of isobutyronitrile (1.382 g, 1.82 mL, 20 mmol) in THF (12 mL) at -78 °C was treated dropwise with 1.5M LDA THF in cyclohexane (14 mL, 21 mmol), stirred for 30 minutes, treated with PhSSPh (4.36 g, 20 mmol), stirred for 30 minutes, warmed to room temperature, quenched with NaHCO 3 , and extracted with diethyl ether. The combined, extracts were dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 0-10% ethyl acetate/pentane to provide the desired product. MS (DCI(+)) m/e 195 (M+18) + . Example 266B 2-methyl-2-(phenylthio)propan- 1 -amine A solution of Example 266A (0.5 g, 2.82 mmol) in THF at room temperature was treated with IM BH 3 THF (15 mL), stirred for 18 hours, quenched with methanol (5 mL), and concentrated. The concentrate was treated with 2M HCl (50 mL) and concentrated. The concentrate was partitioned between dichloromethane and saturated sodium bicarbonate, and the organic phase was dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (DCI(+)) m/e 182 (M+H) + . Example 266C 4-((2-methyl-2-(phenylt o propyPamino)-3-niti'obenzenesulfonamide The desired product was prepared by substituting Example 266B for Example 195A in Example 195B. MS (ESI(-)) m/e 380 (M-H) " . Example 266D N-(4-(8-azaspiro(4.5)dec-8-yl)benzoyl)-4-((2-methyl-2-(phenyltMo)propyPamino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 257C and Example 266C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 621 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.84 (t, IH), 8.63 (d, IH), 7.92 (dd, IH), 7.72 (d, 2H), 7.51-7.35 (m, 5H), 7.16 (d, IH), 6.87 (d, 2H), 3.32-3.24 (m, 6H), 1.62-1.57 (m, 4H), 1.51- 1.40 (m, 8H), 1.31 (s, 6H). Example 267 N-(4-(8-azasρiro(4.5 dec-8-yl)benzoyP-4-((l,l-dimethyl-2-(phenylthio)ethyl)amino)-3- nitrobenzenesulfonamide Example 267A 2-methyl- 1 -(phenylthio)propan-2-amine A mixture of anhydrous CeCb (7.64 g, 31 mmol) in THF (40 mL) at room temperature was stirred for 2 hours, cooled to -78 °C, treated dropwise with 1.4M methyllithium in diethyl ether (21.4 mL, 30 mmol), stirred for 1 hour, treated with PhSCH 2 CN (1.492 g, 10 mmol, 1.3 mL), stirred for 2 hours , warmed to -35 °C over 1 hour, quenched with NH 4 OH, warmed to room temperature, and filtered through diatomaceous earth (Cehte ). The pad was washed with dichloromethane and the organic phase was dried over (MgSO 4 ), filtered, and concentrated. The concentrate was dissolved in 2M HCl, washed with dichloromethane (2 x), and the aqueous phase was concentrated. The concentrate was treated with dichloromethane and neutrahzed with saturated sodium bicarbonate. The organic phase was dried (MgSO 4 ), fUtered, and concentrated to provide the desired product. MS (DCI(+)) m/e 182 (M+H) + . Example 267B 4-(( 1 , 1 -dimethyl-2-(phenylthio) ethyl) amino)-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 267A for Example 195A in Example 195B. MS (ESI(-)) m/e 380 (M-H) " . Example 267C N-(4-(8-azaspiro(4.5)dec-8-yl)berιzoyl)-4-(( nitrobenzenesulfonamide The desired product was prepared by substituting Example 257C and Example 267B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 621 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.98 (br s, IH), 8.50-8.48 (m, 2H), 7.84 (dd, IH), 7.75 (d, 2H), 7.34 (d, IH), 7.29-7.24 (m, 2H), 7.08-6.98 (m, 2H), 6.98 (d, IH), 6.89 (d, 2H), 3.54 (s, 2H), 3.32-3.24 (m, 4H), 1.62-1.56 (m, 4H), 1.56 (s, 6H), 1.51-1.40 (m, 8H). Example 268 4-(((lR)-5---rnino-l-( henylt o)methyl)pentyl)amino)-N-(4-(4.4-dimethylpiperidin-l- yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 261 for Example 120D in Example 120E. MS (ESI(+)) m/e 640 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.55 (d, IH), 8.31 (d, IH), 7.85 (dd, IH), 7.73 (d, 2H), 7.26 (d, 2H), 7.21-7.11 (m, 3H), 7.04 (d, IH), 6.92 (d, 2H), 4.09 (m, 2H), 3.37 (m, 4H), 2.72 (m, 4H), 1.76 (m, 2H), 1.52 (m, 2H), 1.35 (m, 8H), 1.48 (m, 6H), 0.95 (s, 6H). Example 269 4-(((4-(aminomethyPbicvclo(2.2.2)oct- 1 -yl)methyPamino)-N-((4'-fluoro-l .1 '-biphenyl-4- yPcarbonyl)-3-nitrobenzenesulfonamide Example 269A tert-butyl (4-(((4-((((4'-fluoro-l,l , -biphenyl-4-vPcarbonyl)amino)sulfonyl)-2- nitrophenyl)amino)methyl)bicyclo(2.2.2)oct- 1 -ypmethylcarbamate The desired product was prepared by substituting Example 162A for Example IC in Example ID. MS (ESI(-)) m/e 665 (M-H) " . Example 269B 4-(((4-(aminomethvPbicvclo(2.2.2)oct-l-vPmethvPamino)-N-((4'-fluoro-l,l'-biphenyl-4- yl) carbonyP-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 269A for Example 120D in Example 120E. MS (ESI(-)) m/e 565 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.67 (d, IH), 8.50 (t, IH), 7.99-7.93(m, 3H), 7.82-7.77 (m, 3H), 7.71 (br s, 2H), 7.36-7.27 (m, 3H), 3.26-3.17 (d, 2H), 2.55 (q, 2H), 2.52-2.41 (m, 12H). Example 270 4-(( 1 , 1 -dimethyl-2-(phenylthio)ethyPamino)-N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl) carbonyP-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 267B for Example IC in Example ID. MS (ESI(-)) m/e 578 (M-H) " ; 1H NMR (300 MHz, DMSO-d6) δ 8.47-8.51 (m, 2H), 7.98 (d, 2H), 7.86 (dd, IH), 7.72-7.78 (m, 2H), 7.69 (d, 2H), 7.25-7.35 (m, 5H), 7.06- 7.12 (m, 2H), 6.97-7.02 (m, IH), 3.54 (s, 2H), 1.56 (s, 6H). Example 271 4-((l,l-dimethyl-2-(phenylthιo)ethyPamino)-N-(4-(4,4-dimethylpiperidin-l-yl)benzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 267B and Example 119C for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 595 (M-H) " ; l H NMR (300 MHz, DMSO-de) δ 11.97 (br s, IH), 8.50-8.47 (m, 2H), 7.85 (dd, IH), 7.75 (d, 2H), 7.34 (d, IH), 7.26 (d, 2H), 7.08-7.00 (m, 2H), 6.98 (d, IH), 6.90 (d, 2H), 3.54 (s, 2H), 3.36-3.25 (m, 4H), 1.56 (s, 6H), 1.40-1.36 (m, 4H), 0.95 (s, 6H). Example 272 tert-butyl 4-f 4-(T((4-((l , 1 -dimethyl-2-(phenylthio)ethyl)amino)-3- nitrophenyl) sulfonyl) amino) carbonyPphenyPpiperazine- 1 -carboxylate The desired product was prepared by substituting 4-(4- ((neopentyloxy)carbonyl)piperazin-l-yl)benzoic acid and Example 267B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 668 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.49 (t, IH), 7.84 (dd, IH), 7.79 (d, 2H), 7.33 (d, IH), 7.26 (d, 2H), 7.08- 7.02 (m, 2H), 6.98 (d, IH), 6.92 (d, 2H), 3.45 (s, 2H), 3.45-3.38 (m, 4H), 3.31-3.26 (m, 4H), 1.56 (s, 6H), 1.41 (s, 9H). Example 273 N-((4'-fluoro-2-methyl-l , 1 '-biphenyl-4-yPcarbonyl)-3-nitro-4-((2- (phenylthio)ethvPamino)benzenesulfonamide Example 273A ethyl 4'-fluoro-2-methyl-l , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting 4-bromo-3-methylbenzoic acid ethyl ester and 4-fluorophenylboronic acid for Example 186B and Example 186A, respectively, in Example 186C. Example 273B 4'-fluoro-2-methyl- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 273 A for Example 186C in Example 186D. MS (DCI) m/e 231 (M+H) + . Example 273 C N-((4'-fluoro-2-methyl-l .1 '-biphenyl-4-vPcarbonvP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 273B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (DCI) m/e 566 (M+H) ; ! H NMR (300 MHz, DMSO-de) δ 12.43 (br s, IH), 8.78 (t, IH), 8.64 (d, IH), 7.94 (dd, IH), 7.83 (d, IH), 7.75 (dd, IH), 7.41-7.37 (m, 4H), 7.32-7.27 (m, 5H), 7.22 (d, IH), 7.18 (m, IH), 3.68 (q, 2H), 3.29 (q, 2H), 2.25 (s, 3H). Example 274 tert-butyl 5-(4-frff3-nitro-4-f(2- (phenylthio) ethyl) amino)phenyP sulfonyl) amino) carbonypphenyp - 1 -benzothiophene-2- carboxylate Example 274A methyl 5-bromo- 1 -benzothiophene-2-carboxylate A solution of 5-bromo-2-fluorobenzaldehyde (6g, 29.6 mmol), methyl thioglycolate (2.64 mL, 29.6 mmol), and Na 2 CO 3 (3.14g, 29.6 mmol) in methanol was heated to reflux for 1 hour, poured into brine, and extracted with ethyl acetate (3 x). The combined extracts were washed with brine and filtered through sUica gel to provide the desired product. MS (ESI(-)) m/e 270 (M-H) " . Example 274B 5-bromo- 1 -benzothiophene-2-carboxylic acid The desired product was prepared by substituting Example 274A for Example 1 A in Example IB. MS (ESI(-)) m/e 254 (M-H) " . Example 274C tert-butyl 5-bromo- 1 -benzothiophene-2-carboxylate A mixture of Example 274B and concentrated H 2 SO 4 (0.5 mL) in dichloromethane (100 mL) saturated with isobutylene at room temperature was stirred for 4 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with 2% ethyl acetate/hexanes to provide the desired product. Example 274D tert-butyl 5-(4-(methoxycarbonyl)phenyP- 1 -benzothiophene-2-carboχylate The desired product was prepared by substituting Example 274C and 4- (methoxycarbonypphenylboronic acid for methyl 4-bromobenzoate and 4- fluorophenylboronic acid, respectively, in Example 1 A. Example 274E 4-(2-(tert-butoxycarbonyl)- 1 -benzothien-5-yPbenzoic acid The desired product was prepared by substituting Example 274D for Example 1 A in Example IB. MS (ESI(-)) m/e 353 (M-H) " . Example 274F tert-butyl 5-(4-((((3-nitro-4-((2- (phenylthio)ethyPamino)phenvPsulfonyl)amino)carbonyPphenyP-l-benzothiophene-2- carboxylate The desired product was prepared by substituting Example 274E and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 688 (M-H) " ; ! H NMR (300 MHz, DMSO-d 6 ) δ 1.58 (s, 9H), 3.29 (t, 2H), 3.65 (dt, 2H), 7.16 (m, 3H), 7.28 (t, 2H), 7.38 (m, 3H), 7.41 (m, IH), 7.81 (d, IH), 7.88 (d, 2H), 7.92 (dd, IH), 8.01 (d, IH), 8.14 (d, IH), 8.61 (dd, IH), 8.71 (t, IH). Example 275 (3R)-3-((4-((((4'-fluoro-l,r-biphenyl-4-yl)carbonyPamino)sulfonyP-2-nitrophenyPamino -4- (phenylthio)butanoic acid The desired product was prepared by substituting Example 435 for Example 122D in Example 122E. MS (ESI(-)) m/e 608 (M-H) " ; 1H NMR (300 MHz, methanol- ) δ 8.71 (d, IH), 7.99 (d, 2H), 7.92 (dd, IH), 7.68 (m, 4H), 7.26 (m, 2H), 7.21-7.12 (m, 5H), 6.98 (d, IH), 4.40 (m, IH), 3.37 (dd, IH), 3.30 (dd, IH), 2.83 (m, 2H). Example 276 (3R)-3-(r4- (((2 , -methoxy-4'-(3-morphoHn-4-ylρroρvP-l , 1 '-biphenyl-4- yPc-ιrbonypamino)sulfonyP-2-nitrophenyl)amino)-N 1 N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting Example 122F and Example 1220 for Example IC and Example IB, respectively, in Example ID. MS (ESI(-)) m/e 774 (M-H) " ; 1H NMR (500 MHz, methanol-d 4 ) δ 8.72 (d, IH), 8.70 (d, IH), 7.94 (d, 2H), 7.91 (dd, IH), 7.45 (d, 2H), 7.35 (d, IH), 7.18 (m, 4H), 6.92 (s, IH), 6.87 (d, 2H), 3.77 (s, 3H), 3.75 (m, 4H), 3.35 (m, 2H), 2.95 (m, 2H), 2.84 (m, 2H), 2.80 (m, 4H), 2.70 (t, 2H), 1.94 (m, 2H). Example 277 methyl N-(4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yl) carbonyPamdno)sulfonyP-2-nitrophenyl)-S- phenyl-L-cysteinate The desired product was prepared by substituting Example 133C for Example IC in Example ID. MS (ESI(-)) m/e 608 (M-H) " ; 1H NMR (300 MHz, DMSO-dg) δ 3.61 (dd, IH), 3.62 (s, 3H), 3.70 (dd, IH), 5.10 (m, IH), 7.11 (m, 3H), 7.19 (d, IH), 7.27 (d, 2H), 7.31 (dd, 2H), 7.75 (m, 4H), 7.92 (dd, IH), 7.97 (d, 2H), 8.55 (d, IH), 8.80 (d, IH). Example 278 N-(4-( 1 -(cyclohexylmethyl)- 1 H-benzimidazol-5-yl)benzoyl)-4-((( 1 R -2-hydroxy- 1 - ((phenylthio)methyl)ethyl)amino)-3-nitrobenzenesulfonamide Example 278A 4-(((lR)-2-((tert-butyl(dimethyl)silyPoxy)-l-((phenylt o)methyl)ethyl)amino)-3- nitrobenzenesulfonamide A solution of Example 133B (3 g, 9.63 mmol) in 1:1 dioxane/4M HCl (400 mL) was stirred for 90 minutes, poured into saturated Na 2 CO 3 , and extracted with ethyl acetate (3 x). The combined extracts were washed with brine and concentrated. The concentrate was purified by flash column chromatography on sUica gel with ethyl acetate. A solution of the purified product (1.7 g, 8.04 mmol) in THF (100 mL) was treated with IM LAH in THF (16.1 mL), stirred for 30 minutes, treated sequentially with water (4 mL), IM NaOH (4 mL), and water (4 mL), diluted with THF, fUtered through a pad of silica gel, and concentrated. A solution of the concentrate (1.35g, 7.37 mmol), tert-butyldimethylsilyl triflate (1.86 mL, 8.10 mmol), and 2,6-lutidine (0.943 mL, 8.10 mmol) in dichloromethane (50 mL) at 0 °C was stirred for 30 minutes, added to a solution of Example 122C (1.76 g, 8 mmol) in DMF (50 mL) and diisopropylethylamine (15 mL), heated to 50 °C, stirred for 18 hours, poured into water, and extracted with ethyl acetate (3 x). The combined extracts were washed with water and brine, dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 496 (M-H) " . Example 278B N-(4-(l-(cyclohexylmethyl)-lH-benzimidazol-5-yl)benzoyP-4-(((lR)-2-hydroxy-l- ((phenyltMo)methyl)ethyPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 286A and Example 278B for Example IB and Example IC, respectively, in Example ID. The product was dissolved in TFA (5 mL), stirred for 2 hours, concentrated, dissolved in toluene, and concentrated again to provide the desired product. MS (ESI(-)) m/e 698 (M-H) " ; 1H NMR (300 MHz, DMSO- de) δ 0.90-1.35 (m, 6H), 1.58 (m, 5H), 3.02 (m, 3H), 3.18 (m, 2H), 3.54 (dd, IH), 3.68 (dd, " IH), 4.19 (m, IH), 7.16 (m, 2H), 7.21 (d, 2H), 7.30 (d, 2H), 7.62 (m, IH), 7.73 (m, 2H), 7.87 (m, 4H), 7.98 (d, IH), 8.04 (s, IH), 8.59 (d, IH), 8.61 (d, IH). Example 279 (3R)-3-((4-((((4'-fluoro-l,r-biphenyl-4-yPcarbonyl)amino)sulfonyl)-2-nitrophenyPamino)- N-(3-morphoHn-4-ylpropyP-4-(phenylthio)butanamide The desired product was prepared by substituting Example 275 and 4-(3- aminopropypmorphoHne for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 734 (M-H) " ; 1H NMR (500 MHz, methanol-d 4 ) δ 8.65 (d, IH), 8.50 (d, IH), 8.13 (d, 2H), 7.89 (dd, IH), 7.64 (m, 2H), 7.58 (d, 2H), 7.29 (d, 2H), 7.14 (m, 5H), 6.89 (d, IH), 4.40 (m, IH), 3.62 (t, 4H), 3.32 (dd, IH), 3.21 (m, 2H), 3.09 (m, IH), 2.68 (m, 2H), 2.37 (m, 4H), 2.29 (t, 2H), 1.58 (m, 2H). Example 280 N-((4'-fluoro-lJ'-biphenyl-4-yl)carbonyl)-4-(((lR)-3-hydroxy-l- ((phenylthio)methyl)propyP amino)-3 -nitrobenzenesulfonamide Example 280A 4-(((lR)-3-hydroxy-l-((phenylthio methyPpropyPamino -3-nitrobenzenesulfonamide A mixture of Example 122E (206 mg, 0.50 mmol) and IM borane in THF (20 mL) was stirred for 16 hours, treated sequentially with methanol (5.0 mL) and IN HCl (2.0 mL), dUuted with ethyl acetate (50 mL), washed with water (2 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 20-50% ethyl acetate/dichloromethane to provide the desired product. MS (ESI(+)) m/e 398 (M+H) + . Example 280B N-((4'-fluoro-l , 1 , -biphenyl-4-vDcarbonvD-4-((( lR)-3-hydroxy-l- ((phenylthio)methvPpropyl) amino)-3 -nitrobenzenesulfonamide A room temperature solution of Example 280A (150 mg, 0.38 mmol), Example IB (180 mg, 0.83 mmol), EDCI (193 mg, 1.0 mmol), and DMAP (25 mg, 0.20 mmol) in dichloromethane (10 mL) was stirred for 16 hours, dUuted with ethyl acetate (100 mL), washed sequentially with IM HCl (20 mL), water (30 mL) and brine (20 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was dissolved in THF (5 mL), treated with IM LiOH (1.0 mL), stirred for 3 hours, diluted with ethyl acetate (60 mL), washed sequentially with IM HCl (10 mL), water (20 mL), and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 30-100% ethyl acetate/dichloromethane to provide the desired product. MS (ESI(-)) m/e 594 (M-H) " ; H NMR (500 MHz, methanol-d 4 ) δ 8.72 (d, IH), 7.92 (m, 3H), 7.70 (m, 4H), 7.26 (m, 2H), 7.18 (tt, 2H), 7.11 (m, 3H), 7.00 (d, IH), 4.25 (m, IH), 3.68 (m, 2H), 3.39 (d, IH), 3.21 (m, 3H), 2.08 (m, IH), 1,97 (m, IH). Example 281 4-(((lR)-2-hydroxy-l-((phenylt o)methyl)ethyl)amino)-N-((2'-methoxy-4'-(3-morphoHn-4- yl-3-oxopropyl)-l , 1 '-bipheny 1-4-yl) carbonvP-3 -nitrobenzenesulfonamide Example 281 A 2'-methoxy-4'-(3-morphoHn-4-yl-3-oxopropyP- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 122M for Example 1 A in Example IB. Example 28 IB 4-(((lR)-2-hvciroxy-l-((phenylt o)methyPethyPamino)-N-((2'-methoxy-4'-(3-morphoUn-4- yl-3-oxopropyl)- 1 , 1 '-biphenyl-4-yl)carbonyP-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 281 A and Example 278 A for Example IB and Example IC, respectively, in Example ID. The product was dissoved in TFA (5 mL), stirred for 2 hours, concentrated, dissolved in toluene, and concentrated again to provide the desired product. MS (ESI(-)) m/e 733 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 2.66 (t, 2H), 2.85 (t, 2H), 3.28 (m, 2H), 3.43 (m, 4H), 3.52 (m, 4H), 3.62 (m, IH), 3.71 (m, IH), 3.76 (s, 3H), 3.96 (m, IH), 5.41(dd, IH), 6.90 (d, 2H), 6.99 (s, IH), 7.20 (dd, 2H), 7.28 (dd, 2H), 7.35 (d, 2H), 7.43 (d, 2H), 7.81 (dd, IH), 7.89 (d, 2H), 8.47 (d, IH), 8.51 (t, IH). Example 282 N-(4-(8-azaspiro,4.5)dec-8-vPbenzovP-4-((( 1 R)-2-hvdroxy- 1 - ((phenylthio)methyp ethyl) amino) -3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 257C and Example 278A for Example IB and Example IC, respectively, in Example ID. The product was dissoved in TFA (5 mL), stirred for 2 hours, concentrated, dissolved in toluene, and concentrated again to provide the desired product. MS (ESI(-)) m/e 623 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 1.45 (m, 8H), 1.59 (m, 4H), 3.27 (m, 4H), 3.62 (dd, IH), 3.69 (dd, IH), 4.04 (m, IH), 5.21 (t, IH), 6.84 (d, IH), 6.92 (d, 2H), 7.08 (d, IH), 7.18 (d, IH), 7.21 (m, 2H), 7.31 (d, 2H), 7.71 (d, IH), 7.82 (dd, IH), 8.56 (d, IH), 8.57 (t, IH). Example 283 4-((( 1 R)-5-amino- 1 -((phenyltMo)methyPpentyl)amino -N-((4'-(3-hydroxypropyl)-2'- methoxy-l,r-biphenyl-4-yPcarbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 45 IB for Example 122N in Example 194. MS (ESI(-)) m/e 691 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.55 (d, IH), 8.35 (br d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.58 (d, 2H), 7.25-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.10 (m, IH), 3.75 (s, 3H), 3.72 (s, 2H), 3.35 (m, 2H), 2.70-2.605 (m, 6H), 1.75 (m, 4H), 1.50 (m, 2H), 1.40 (m, 2H). Example 284 4-(((lR)-5-amino-l-((phenylthio)methyPpentyPamino)-N-(4-(5-fluoroquinoHn-8- yPbenzoyl) -3 -nitrobenzenesulfonamide Example 284A methyl 4-(5-fluoroquinoUn-8-yl)benzoate The desired product was prepared by substituting Example 389A for Example 5A in Example 5B. Example 284B 4-(5-fluoroquinolin-8-yl)benzoic acid The desired product was prepared by substituting Example 284A for Example 1 A in Example IB. Example 284C 4-(((lR)-5-amino-l-((phenylthio)methyl)pentyPamino)-N-(4-(5-fluoroquinoHn-8- vPbenzoyp-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 284B for Example 122N in Example 194. MS (ESI(-)) m/e 674 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 9.00 (dd, IH), 8.90 (br d, IH), 8.60 (d, IH), 8.58 (dd, IH), 7.90 (d, 2H), 7.85 (m, 2H), 7.75 (d, 2H), 7.70 (m, IH), 7.55 (m, IH), 7.25-7.12 (m, 6H), 4.15 (m, IH), 3.45 (m, 2H), 2.75 (m, 2H), 2.80 (s, 3H), 1.80 (m, 2H), 1.55 (m, 2H), 1.40 (m, 2H). Example 285 N-(4-(6-methoxy-3,4-dihydroisoquinoHn-2(lH)-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 285A ethyl 4-(6-methoxy-3,4-dihydroisoquinn1iτι-2π HVypbenzoate The desired product was prepared by subtituting 6-methoxy-l,2,3,4- tetrahydroisoquinoHne (prepared according to the procedure described in U.S. Patent 1,845,403) for l,4-dioxa-8-azasprio(4,5)decane in Example 158A. MS (DCI) m/e 312 (M+H) + . Example 285B 4-(6-methoxy-3,4-dihydroisoquinolin-2(lH)-yl)benzoic acid The desired product was prepared by subtituting Example 285A for Example 119B in Example 119C. MS (DCI) m/e 283 (M+H) + . Example 285C N-(4-(6-methoxy-3,4-dihydroisoquinoHn-2(lH)-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 285B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 617 (M-H) " ; li NMR (300 MHz, DMSO-d 6 ) δ 11.98 (s, IH), 8.71 (t, IH), 8.56 (d, IH), 7.90 (dd, IH), 7.77 (d, 2H), 7.37 (d, 2H), 7.27 (t, 2H), 7.16 (m, 3H) 6.93 (d, 2H), 6.78 (m, 2H), 4.43 (s, 2H), 3.72 (s, 3H), 3.65 (m, 2H), 3.58 (t, 2H), 3.28 (m, 2H), 2.88 (t, 2H). Example 286 tert-butyl (5R)-5-((4-(((4-( 1 -(cyclohexylmethyp- 1 H-benzimidazol-5- vPbenzovPamino sulfonvP-2-nitrophenyPamino)-6-(phenylthio)hexylcarbamate Example 286A 4-bromo-N -(cyclohexylmethypbenzene- 1 ,2-diamine The desired product was prepared by substituting cyclohexylmethylamine for butylamine in Examples 166A and 166B. Example 286B 4-( 1 -(cyclohexylmethyp- lH-benzimidazol-5-yPbenzoic acid The desired product was prepared by substituting Example 286A for Example 170A in Examples 170B and 170C. Example 286C tert-butyl (5R)-5-((4-(((4-(l-(cyclohexylmethyl)-lΗ-benzimidazol-5- yl)berjzoyl)ar-uno)sulfonyP-2-nitrophenyl)amino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 286B and Example 124C for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 839, 841 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 0.95-1.20 (m, 7H), 1.32 (m, HH), 1.48-1.76 (m, IH), 1.85 (m, IH), 2.86 (m, 2H), 3.98 (t, 2H), 4.02 (m, IH), 4.12 (d, 2H), 6.72 (t, H), 6.98 (d, IH), 7.14 (tt, IH), 7.21 (t, 2H), 7.29 (dd, 2H), 7.59 (dd, IH), 7.68 (d, 3H), 7.84 (dd, IH), 7.95 (d, IH), 7.97 (d, 2H), 8.19 (d, IH), 8.23 (t, IH), 8.49 (d, IH). Example 287 4-((( 1 R)-5-amino- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(8-azaspiro(4.5)dec-8- yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 257D for Example 120D in Example 120E. MS (ESI(+)) m/e 766 (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 8.52 (d, IH), 8.31 (d, IH), 8.85 (dd, IH), 7.72 (d, 2H), 7.68 (s, 2H), 7.24 (t, 2H), 7.12 (m, 2H), 6.91 (d, 2H), 4.10 (m, IH), 3.42 (m, 4H), 3.31 (m, 6H), 2.71 (m, 2H), 1.77 (m, 2H), 1.59 (m, 4H), 1.52 (m, 2H), 1.45 (m, 6H). Example 288 (3R)-3-((4-(((4-(5-fluoroquinoHn-8-yl)benzoyPamino)sulfonyP-2-nitrophenyl)amino)-N,N- dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting Example 284B for Example 126A in Example 126B. MS (ESI(-)) m/e 686 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 9.00 (dd, IH), 8.90 (br d, IH), 8.60 (d, IH), 8.58 (dd, IH), 7.90 (d, 2H), 7.85 (m, 2H), 7.75 (d, 2H), 7.70 (m, IH), 7.55 (m, IH), 7.25-7.12 (m, 6H), 4.45 (m, IH), 3.45 (m, 2H), 2.90 (s, 3H), 2.80 (s, 3H), 3.00-2.80 (m, 2H). Example 289 (3R)-3-^4-((((2'-methoxy-4'-(3-morphoUn-4-yl-3-oxopropyl)-l,r-biρhenyl-4- yl)carbonyl)amino)sulfonyl)-2-nitrophenyPamino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting Example 122M for Example 126A in Example 126B. MS (ESI(-)) m/e 788 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.89 (br d, IH), 8.57 (d, IH), 7.90 (d, 2H), 7.85 (dd, IH), 7.78 (br d, IH), 7.58 (d, 2H), 7.30-7.12 (m, 7H), 7.00 (d, IH), 6.89 (dd, IH), 4.45 (m, IH), 3.75 (s, 3H), 3.55 (m, 4H), 3.45 (m, 6H), 2.90 (s, 3H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.65 (t, 2H). Example 290 4-((( 1 R)-3 -hydroxy- 1 -((phenylthio)methyppropyl) amino)-N-((2'-methoxy-4 '-(3 -morpholin- 4-ylpropyl)- 1 , 1 '-biphenyl-4-yi)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 1220 for Example IB in Example 280B. MS (ESI(-)) m/e 774 (M-H) " ; 1H NMR (500 MHz, methanol-c ) δ 8.72 (d, IH), 8.69 (d, IH), 7.95 (d, 2H), 7.90 (dd, IH), 7.45 (d, 2H), 7.34 (d, 2H), 7.22-7.10 (m, 5H), 6.92 (s, IH), 6.85 (d, IH), 4.40 (m, IH), 3.77 (s, 3H), 3.80-3.72 (m, 4H), 3.36 (m, 3H), 2.95 (m, 2H), 2.85 (m, 2H), 2.79 (m, 3H), 2.70 (m, 4H), 1.95 (m, 3H). Example 291 4-((2-((4-chlorophenyl)thio)ethyl)amino)-N-((4 '-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyP-3- nitrobenzenesulfonamide Example 291 A 2-((4-chlorophenyl)thio)ethanamine A solution of sodium metal (22.5 mg, 0.98 mmol) in ethanol (2.0 mL) was treated with 2-bromoethylamine hydrobromide (100.0 mg, 0.49 mmol) and 4-chlorobenzenethiol (71.0 mg, 0.49 mmol), heated to 75 °C for 18 hours, and concentrated. The concentrate was partitioned between water (2.0 mL) and diethyl ether (5.0 mL) and the organic phase was dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (DCI) m/e 188 (M+H) + . Example 29 IB 4-((2-((4-chlorophenyPthio)ethyl)amino)-N-((4'-fluoro-l,r-biphenyl-4-yl)carbonyP-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 291 A for 2,2- dimethylcyclopentylamine in Example IE. MS (DCI) m/e 603 (M+NH 4 ) + ; H NMR (300 MHz, DMSO-d 6 ) δ 12.49 (br s, IH), 8.76 (t, IH), 8.64 (d, IH), 7.97-7.95 (m, 3H), 7.80-7.77 (m, 4H), 7.39-7.38 (m, 2H), 7.34-7.30 (m, 4H), 7.24 (d, IH), 3.68 (q, 2H), 3.30 (q, 2H). Example 292 4-(((lR)-5-anLuno-l-((phenyltMo)methyPpentyP-ιmino)-3-nitro-N-(4-(5- (trifluoromethyl)pyridin-2-yl)benzoyl)benzenesulfonamide The desired product was prepared by substituting Example 124C and Example 253B for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m/e 674, 672 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 9.09 (dd, IH), 8.59 (d, IH), 8.35- 8.29 (m, 5H), 8.06 (d, 2H), 7.90 (dd, IH), 7.25 (dt, 2H), 7.15 (td, 2H), 7.10 (tt, IH), 4.12 (m, IH), 3.37 (t, 2H), 2.73 (m, 2H), 1.77 (q, 2H), 1.54 (m, 2H), 1.39 (m, 2H). Example 293 N-(4-(5-chloropyridin-2-yl)benzoyl)-4-((( 1 R)-5-(dimethylamino)- 1 - ((phenylthio)methyl)pentyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 254B for Example 257C in Example 124F. MS (ESI) m/e 668, 666 (M+H) + , (M-H) " ; ! H NMR (500 MHz, DMSO-d 6 ) δ 10.02 (s, IH), 8.75 (dd, IH), 8.58 (d, IH), 8.33 (d, IH), 8.21 (d, 2H), 8.12 (d d, IH), 8.06 (dd, IH), 8.01 (d, 2H), 7.90 (dd, IH), 7.25 (dt, 2H), 7.15 (td, 2H), 7.10 (tt, IH), 4.12 (m, IH), 3.36 (d, 2H), 2.95 (m, 2H), 2.69 (s, 3H), 2.69 (s, 3H), 1.78 (q, 2H), 1.63 (m, 2H), 1.36 (m, 2H). Example 294 4-(((lR)-5-(dimethylamino)-l-((phenylthio)methyl)pentyPamino)-3-nitro-N-(4-quinoHn-8- ylbenzovPbenzenesulfonamide Example 294A methyl 4-quinolin-8-ylbenzoate The desired product was prepared by substituting 8-bromoquinoHne for 5-bromo-2- methoxypyridine in Example 252D. MS (ESI) m/e 250, 248 (M+H) + , (M-H) " . Example 294B 4-quinoHn-8-ylbenzoic acid The desired product was prepared by substituting Example 294A for Example 252F in Example 252G. Example 294C 4-(((lR)-5-(dimethylamino)-l-((phenylthio)methyl)pentvPamino)-3-nitro-N-(4-quinolin-8- ylbenzoypbenzenesulfonamide The desired product was prepared by substituting Example 294B for Example 257C in Example 124F. MS (ESI) m/e 684, 682 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 10.34 (s, IH), 8.94 (dd, IH), 8.59 (d, IH), 8.55 (dd, IH), 8.33 (d, IH), 8.19 (dd, IH), 8.07 (d, 2H), 8.00 (d, IH), 7.92 (dd, IH), 7.86 (dd, IH), 7.82 (d, 2H), 7.80-7.72 (m, 2H), 7.65 (m, IH), 7.31-7.10 (m, 5H), 4.16 (m, IH), 3.37 (m, 2H), 2.95 (m, 2H), 2.69 (s, 3H), 2.67 (s, 3H), 1.78 (m, 2H), 1.64 (m, 2H), 1.38 (m, 2H). Example 295 4-(((lR)-5-(dimethylamino)-l-((phenyltMo)methyl)pentyl)amino)-N-((4'-(3-hydroxypropyP- 2'-methoxy- 1 , 1 '-bipheny l-4-yl)carbonyl)-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 451B for Example 257C in Example 124F. The crude product was dissolved in THF, treated with TBAF (50 mg), stirred for 3 hours, and concentrated. The concentrate was purified by HPLC (using a C-18 column and a solvent system increasing in gradient from 10-95% acetonitrile/water containing 0.1% TFA) to provide the desired product which was converted to the hydrochloride salt by dissolving the product in methanol and 2M HCl in diethyl ether then concentrating. MS (ESI) m/e 721, 719 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.57 (d, IH), 8.32 (d, IH), 7.89 (d, 2H), 7.59 (d, 2H), 7.27-7.10 (m, 8H), 6.97 (d, IH), 6.87 (d,H), 4.12 (m, IH), 3.76 (s, 3H), 3.44 (t, 2H), 3.36 (m, 2H), 2.95 (m2H), 2.69 (s, 3H), 2.67 (s, 3H), 2.65 (m, 2H), 1.77 (m, 2H), 1.64 (m, 2H), 1.36 (m, 2H). Example 296 4-((( 1 R)-5-(dimethylamino)- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(4-methoxy-2- oxopyridin- 1 (2H)-yPbenzoyP-3-nitrobenzenesulfonamide Example 296A methyl 4-(4-hydroxy-2-oxopyridin-l (2H -vPbenzoate A mixture of methyl 4-iodobenzoate (0.421 g, 1.6 mmol), 2,4-dihydroxypyridine (0.174 g, 1.34 mmol), Cul (25 mg, 0.134 mmol) and K 2 CO 3 (200 mg) in DMF (2 mL) was heated to 150 °C in a sealed vial for 4 hours, diluted with ethyl acetate (100 mL), washed with water (30 mL) and brine (30 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 2: 1 hexanes/ethyl acetate to provide the desired product. MS (APCI) m/e 246 (M+H) . Example 296B methyl 4-(4-methoxy-2-oxopyridin- 1 (2H)-yl)benzoate A solution of Example 296A (2.3g, lOmmol) in acetone (300 mL) was treated with iodomethane (5 mL) and K 2 CO 3 (15 g), heated to reflux for 18 hours, and filtered. The filtrate was concentrated and he concentrate purified by flash column chromatography on sUical gel with 4: 1 hexanes/ethyl acetate to provide the desired product. MS (ESI) m/e 260 (M+H) + . Example 296C 4-(4-methoxy-2-oxopyridin- 1 (2H)-yl)benzoic acid The desired product was prepared by substituting Example 296B for Example 252F in Example 252G. MS (ESI) m/e 246, 244 (M+H) + , (M-H) " . Example 296D 4-((( 1 R)-5-(dimethylamino)- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(4-methoxy-2- oxopyridin-l(2H)-vPbenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 296C for Example 257C in Example 124F. MS (ESI) m e 680, 678 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.57 (d, IH), 8.33 (d, IH), 8.05 (d, IH), 7.99 (d, 2H), 7.89 (dd, IH), 7.57 (d, IH), 7.52 (d, 2H), 7.10-7.33 (m, 5H), 6.07 (dd, IH), 5.88 (d, IH), 4.12 (m, IH), 3.89 (s, 3H), 3.36 (m, 2H), 2.95 (m, 2H), 2.69 (s, 3H), 2.67 (s, 3H), 1.77 (m, 2H), 1.64 (m, 2H), 1.34 (m, 2H). Example 297 4-(((lR)-5-amino-l-((phenyltl io)methyl)pentyl)amino)-N-(4-(4-methoxy-2-oxopyridin- l(2H)-yPbenzoyP-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 124C and Example 296C for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m/e 652, 650 (M+H) + , (M-H) " ; ! H NMR (500 MHz, DMSO-d 6 ) δ 8.57 (d, IH), 8.33 (d, IH), 8.05 (d, IH), 7.99 (d, 2H), 7.89 (dd, IH), 7.57 (d, IH), 7.52 (d, 2H), 7.25 (dt, 2H), 7.15 (td, 2H), 7.10 (tt, IH), 6.08 (dd, IH), 5.88 (d, IH), 4.12 (m, IH), 3.89 (s, 3H), 3.36 (t, 2H), 2.73 (m, 2H), 1.76 (q, 2H), 1.56 (m, 2H), 1.39 (m, 2H). Example 298 , 4-(((lR)-5-amino-l-((phenylthio)methyPpentyl)amino)-N-((6-(4-fluorophenyl)pyridin-3- ypcarbonyP-3-nitrobenzenesulfonamide Example 298A methyl 6-(4-fluorophenyl)nicotinate The desired product was prepared by substituting methyl 6-chloronicotinate and 4- fluorobenzeneboronic acid for 5-bromo-2-methoxypyridine and 4- methylcarboxybenzeneboronic acid, respectively, in Example 252D. MS (APCI) m/e 232 (M+H) + . Example 298B 6-(4-fluorophenyl)nicotinic acid The desired product was prepared by substituting Example 298A for Example 252F in Example 252G. MS (ESI) m/e 218, 216 (M+H) + , 216(M-H) " . Example 298C 4-(((lR)-5-anιino-l-((phenylthio)methyl)pentyl)amino -N-((6-(4-fluorophenyPpyridin-3- ypcarbonyP-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 124C and Example 298B for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m/e 624, 622 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 9.10(d, IH), 8.59 (d, IH), 8.36-8.33 (m, 2H), 8.24-8.21 (m, 2H), 8.16-8.12 (m, IH), 7.91 (dd, IH), 7.39-7.31 (m, 2H), 7.25 (dt, 2H), 7.15 (td, 2H), 7.10 (tt, IH), 6.94 (d, IH), 4.12 (m, IH), 3.37 (t, 2H), 2.73( m, 2H), 1.76 (q, 2H), 1.56 (m, 2H), 1.39 (m, 2H). Example 299 4-(((lR)-5-amino-l-((phenylthio)methyPpentyl)amino)-N-(4-(6-methoxypyridin-3- yl)benzoyl)-3-nitrobenzenesulfonamide Example 299A 4-(6-methoxypyridin-3-yl)benzoic acid The desired product was prepared by substituting Example 252D for Example 252F in Example 252G. MS (ESI) m/e 230(M+H) + , m/e 228 (M-H) " . Example 299B 4-(((lR -5-amino-l-((phenylthio)methyl)pen1yPamino)-N-(4-(6-methoxypyi'idin-3- yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 124C and Example 299 A for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m e 636, 634 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 8.58 (d, IH), 8.33 (d, IH), 8.06 (dd, IH), 8.09 (dd, IH), 8.02 (d, 2H), 7.98 (d, IH), 7.91 (dd, IH), 7.83 (d, 2H), 7.81 (s, IH), 7.25 (dt, 2H), 7.15 (td, 2H), 7.10 (tt, IH), 6.94 (d, IH), 4.12 (m, IH), 3.91 (s, 3H), 3.36 (t, 2H), 2.73 (m, 2H), 1.76 (q, 2H), 1.56 (m, 2H), 1.39 (m, 2H). Example 300 2-(4'-((((4-(rπR)-5-(;dimethylamino)-l-((phenylthio)methvPpentvPamino)-3- nitrophenyl)sulfonyl)amino)carbonyl)-2-methoxy- 1.1 '-biphenyl-4-yl)-N,N- dimethylacetamide The desired product was prepared by substituting Example 441 A and Example 122F for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI) m/e 748, 746 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 9.95 (s, IH), 8.57 (d, IH), 8.34 (d, IH), 7.98 (d, 2H), 7.90 (d, IH), 7.62 (d, 2H), 7.60 (d, IH), 7.28-7.24 (m, 3H), 7.18-7.08 (m, 3H), 7.01 (dd, IH), 6.90 (dd, 2H), 4.12 (m, 1H),3.87 (s, 3H), 3.76 (s, 3H), 3.73 (t, 2H), 3.36 (m, 2H), 3.03 (s, 3H), 2.85 (s, 3H), 2.68 (d, 2H), 1.77 (q, 2H), 1.64 (m, 2H), 1.36 (m, 2H). Example 301 4-((( 1 R)-5-f dimethylamino)- 1 -((phenyltMo)methyl)pentyl)amino)-N-((2'-methoxy-4'-(3- morphoHn-4-yl-3-oxopropyP-l,r-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 1220 for Example 257C in Example 124F. MS (ESI) m/e 804, 802 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 10.02 (s, IH), 8.57 (d, IH), 8.34 (d, IH), 7.97 (d, IH), 7.90 (d, 2H), 7.60 (d, IH), 7.58 (d, 2H), 7.27-7.10 (m, 6H), 7.03 (dd, IH), 6.94 (dd, IH), 4.12 (m, IH), 3.75 (s, 3H), 3.51 (m, 4H), 3.44 (m, 4H), 3.36 (m, 2H), 2.95 (m, 2H), 2.86 (m, 2H), 2.69 (s, 3H), 2.67 (s, 3H), 1.77 (q, 2H), 1.64 (m, 2H), 1.36 (m, 2H). Example 302 4-(((lR)-5-amino-l-((phenylthio)methyl)pentyl)amino)-N-(4-(6-cMoropyridin-3-yl)benzoyP- 3 -nitrobenzenesulfonamide The desired was prepared by substituting Example 124C and Example 252G for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m/e 638 (M- H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 8.81 (dd, IH), 8.58 (d, IH), 8.34 (d, IH), 8.23 (dd, IH), 8.02 (d, 2H), 7.90 (d, 2H), 7.89 (dd, IH), 7.64 (d, IH), 7.25 (dt, 2H), 7.15 (td, 2H), 7.10 (tt, IH), 4.12 (m, IH), 3.36 (t, 2H), 2.73 (m, 2H), 1.76 (q, 2H), 1.56 (m, 2H), 1.39 (m, 2H). Example 303 4-(((lR -5-amino-l-((phenylthio)methyppentyPamino)-N-(4-(5-chloropyridin-2-vPbenzovP- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 124C and Example 254B for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m/e 640, 638 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.74 (dd, IH), 8.58 (d, IH), 8.34 (d, IH), 8.20 (d, 2H), 8.12 (d, IH), 8.06 (dd, IH), 8.01 (d, 2H), 7.90 (dd, IH), 7.25 (dt, 2H), 7.15 (td, 2H), 7.10 (tt, IH), 4.12 (m, IH), 3.36 (t, 2H), 2.73 (m, 2H), 1.76 (q, 2H), 1.56 (m, 2H), 1.39 (m, 2H). Example 304 4-(((lR)-5-(dimethylamino)-l-((phenylthio)methyl)pentyPammo)-N-(4-(5-fluoroquinoUn-8- yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 284B for Example 257C in Example 124F. MS (ESI) m/e 702, 700 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.98 (dd, IH), 8.59 (d, IH), 8.87 (dd, IH), 8.06 (d, IH), 7.99 (d, 2H), 7.92 (dd, IH), 7.84 (d, IH), 7.80 (d, IH), 7.77 (d, 2H), 7.70 (q, IH), 7.67 (t, IH), 7.29-7.10 ( , 5H), 4.12 (m, IH), 3.36 (m, 2H), 2.95 (m, 2H), 2.69 (s, 3H), 2.67 (s, 3H), 1.77 (q, 2H), 1.64 (m, 2H), 1.36 (m, 2H). Example 305 4-((( 1 R)-5-(dimethylamino)- 1 -((phenylthio)methyl)pentyl)amino)-3 -nitro-N-(4-(5- (trifluoromethyl)pyridin-2-yPbenzovPbenzenesulfonarnide The desired product was prepared by substituting Example 253B for Example 257C in Example 124F. MS (ESI) m/e 702, 700 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 9.08 (d, IH), 8.58 (d, IH), 8.34-8.30 (m, 2H), 8.30 (d, 2H), 8.10 (d, IH), 8.06 (d, 2H), 7.92 (dd, IH), 7.27-7.10 (m, 5H), 4.12 (m, IH), 3.36 (m, 2H), 2.95 (m, 2H), 2.69 (s, 3H), 2.67 (s, 3H), 1.77 (q, 2H), 1.64 (m, 2H), 1.36 (m, 2H). Example 306 4-((( 1 R)-5-amino- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(5-chloro-2-oxopyridin- 1 (2H)- vPbenzoyl)-3-nitrobenzenesulfonamide Example 306A methyl 4-(5-chloro-2-oxopyridin- 1 (2H)-yl)benzoate The desired product was prepared by substituting 5-chloro-2-hydroxypyridine for 2,4- dihydroxypyridine in Example 296A. MS (ESI) m/e 264 (M+H) + Example 306B 4-(5-chloro-2-oxopyridin-l (2H)-vP benzoic acid The desired product was prepared by substituting Example 306A for Example 252F in Example 252G. MS (ESI) m/e 250, 248 (M+H) + , (M-H) " . Example 306C 4-((( 1 R)-5-amino- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(5-chloro-2-oxopyridin- 1 (2H)- yPbenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 124C and Example 306B for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m/e 656, 654 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-de) δ 8.58 (d, IH), 8.34 (d, IH), 8.01 (d, 2H), 7.95 (d, IH), 7.89 (dd, IH), 7.60 (d, 2H), 7.58 (dd, IH), 7.26 (dt, 2H), 7.14 (td, 2H), 7.10 (tt, IH), 6.54 (d, IH), 4.12 (m, IH), 3.36 (t, 2B), 3.73 (m, 2H), 1.76 (q, 2H), 1.56 (m, 2H), 1.39 (m, 2H). Example 307 4-((( 1 R)-5-(dimethylamino)- 1 -(rphenylthio)methyl)pentyl)amino)-N-(4-( 1 -methyl-6-oxo- 1.6- dihvdropyridin-3-yl)benzoyl)-3-nitrobenzenesulfonamide Example 307A methyl 4-( 1 -methyl-6-oxo- 1 ,6-dihvdropyridin-3-yl)benzoate The desired product was prepared by substituting Example 252E for Example 296A in Example 296B. MS (APCI) m/e 244 (M+H) + . Example 307B 4-( 1 -methyl-6-oxo- 1 ,6-dihydropyridin-3-yl)benzoic acid The desired product was prepared by substituting Example 307A for Example 252F in ,+ Example 252G. MS (APCI) m/e 230 (M+H) → Example 307C 4-((( 1 R)-5-(dimethylamino)- 1 -((phenylthio)methyl)pentypamino)-N-(4-( 1 -methyl-6-oxo- 1 ,6- dihydropyridin-3-yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 307B for Example 257C in Example 124E. MS (ESI) m/e 664(M+H) + , m/e 662 (M-H) " ; 1H NMR (500 MHz, DMSO- de) δ 8.57 (d, IH), 8.33 (d, IH), 8.31 (d, IH), 7.95 (d, 2H), 7.92-7.88 (m, 2H), 7.81 (m, 3H), 7.73 (d, 2H), 7.24 (dt, 2H), 7.22 (d, IH), 7.14 (td, IH), 7.10 (tt, IH), 6.49 (d, IH), 4.12 (m, IH), 3.52 (s, 3H), 3.36 (m, 2H), 2.95 (m, 2H), 2.69 (s, 3H), 2.67 (s, 3H), 1.77 (q, 2H), 1.64 (m, 2H), 1.36 (m, 2H). Example 308 4-((( 1 R)-5-amino- 1 -((phenylthio)methyl)pentypamino)-N-(4-( 1 -methyl-6-oxo- 1 ,6- dihydropyridin-3 -yl)benzoyP-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 124C and Example 307B for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m/e 634 (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 8.57 (d, IH), 8.33 (d, IH), 8.31 (d, IH), 7.95 (d, 2H), 7.92-7.88 (m, 2H), 7.81 (m, 3H), 7.73 (d, 2H), 7.24 (dt, 2H), 7.22 (d, IH), 7.14 (td, IH), 7.10 (tt, IH), 6.49 (d, IH), 4.12 (m, IH), 3.52 (s, 3H), 3.36 (t, 2H), 3.73 (m, 2H), 1.76 (q, 2H), 1.54 (m, 2H), 1.39 (m, 2H). Example 309 3-nitro-N-(4-(3-phenylpyrroHdin- 1 -yPbenzoyl)-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 309A ethyl 4-(2,5-dioxo-3-phenylpyrroHdin-l-yl)benzoate The desired product was prepared by substituting 3-phenyldihydrofuran-2,5-dione for 3,3-dimethylglutaric anhydride in Example 119A. MS (DCI) m/e 324 (M+H) + . Example 309B ethyl 4-(3-phenylpyrroHdin-l-yl)benzoate The desired product was prepared by substituting Example 309A for Example 119A in Example 119B. MS(DCI) m/e 296 (M+H) + . Example 309C 4-(3-phenylpyrroHdin- 1 -ypbenzoic acid The desired product was prepared by substituting Example 309B for Example 119B in Example 119C. MS (DCI) m/e 268 (M+H) + . Example 309D 3-nitro-N-(4-(3-phenylpyrroHdin- 1 -yl)benzoyl)-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 309C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 603 (M+H) + ; ! H NMR (300 MHz, DMSO-d 6 ) δ 11.90 (s, IH), 8.75 (t, IH), 8.59 (d, IH), 7.91 (dd, IH), 7.74 (d, 2H), 7.35 (m, 5H), 7.27 (t, 2H), 7.14-7.30 (m, 5H) 6.58 (d, 2H), 3.78 (dd, IH), 3.66 (m, 2H), 3.53 (t, 2H), 3.42 (m, IH), 3.30 (m, 3H), 2.40 (m, IH), 2.10 (m, IH). Example 310 N-(2-((4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yPcarbonyl)arnino)sulfonyP-2-nitrophenyPamino)-3- (phenylthio)propyl)acetamide A solution of Example 408 (16 mg, 0.026 mmol) in THF (1 mL) and dichloromethane (0.5 mL) at room temperature was treated with saturated sodium bicarbonate (0.2 mL) and acetyl chloride (0.1 mL), stirred for 18 hours, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 30-100% ethyl acetate/dichloromethane to provide the desired product. MS (ESI(~)) m/e 621 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.54 (d, IH), 8.35 (d, IH), 8.23 (t, IH), 7.96 (d, 2H), 7.84 (dd, IH), 7.75 (m, 5H), 7.35-7.10 (m, 7H), 4.05 (m, IH), 1.74 (t, 3H), and remaining protons (4) are buried under solvent peaks. Example 311 N-((2,4'-difluoro~ 1.1 '-biphenyl-4-vPcarbonvP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 311 A methyl 4-bromo-3-fluorobenzoate A solution of 4-bromo-3-fluorobenzoic acid (117 mg, 0.50 mmol) in methanol (1 mL) and dichloromethane (2 mL) at room temperature was slowly treated with 2M trimethylsilyldiazomethane in hexanes until the solution became light yellow. The mixture was concentrated to provide the desired product. Example 31 IB methyl 2,4'-difluoro- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 311 A and 4- fluorophenylboronic acid for Example 5A and (4-methoxycarbonylphenyl)boronic acid, respectively, in Example 5B. Example 3 HC N-(f 2.4'-difluoro- 1.1 '-biρhenyl-4-vPcarbonvP-3 -nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 3 HB and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 568 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.76 (t, IH), 8.61 (d, IH), 7.94 (dd, IH), 7.82 (m, IH), 7.79 (s, IH), 7.65 (m, 3H), 7.40-7.15 (m, 8H), 3.66 (q, 2H), 3.20 (t, 2H). Example 312 4-((2-(((ethylamino)carbonyPamino)-l -((phenylthio)methypethypamino -N-((4'-fluoro- 1,1'- biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting ethyl isocyanate for acetyl chloride in Example 310. MS (ESI(-)) m/e 650 (M-H) " ; 1H NMR (400 MHz, methanol-d 4 ) δ 8.74 (d, IH), 7.93 (m, 3H), 7.68 (m, 4H), 7.31 (m, 2H), 7.15 (m, 5H), 7.03 (d, IH), 4.16 (m, IH), 3.45 (m, 2H), 3.35 (dd, IH), 3.17 (dd, IH), 3.05 (q, 2H), 1.01 (7, 3H), and remaining proton is buried under solvent peaks. Example 313 N-(4-(4-benzylpiperazin-l-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting benzaldehyde for (l-benzyl-2-oxo- ethyl)-carbamic acid tert-butyl ester in Example 173. MS (ESI(-)) m e 630 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.56 (t, IH), 8.51 (d, IH), 7.87 (dd, IH), 7.73 (d, 2H), 7.41-7.26 (m, 8H), 7.21 (d, 2H), 7.02 (d, IH), 6.84 (d, 2H), 3.63 (q, 2H), 3.55 (s, 2H), 3.31-3.20 (m, lOH), 2.81 (dd, IH). Example 314 N-(4-(2-(4,4-dimethyl-3-oxopentyl)-l,3-benzothiazol-5-yPbenzoyP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting 1-bromopinacolone for allyl bromide in Example 213. MS (ESI) m/e 701, 703 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 0.95 (s, 3H), 2.52 (t, 2H), 2.73 (s, 3H), 2.89 (s, 3H), 3.27 (t, 2H), 3.29 (t, 2H), 3.61 (dt, 2H), 7.02 (d, IH), 7.19 (t, IH), 7.31 (t, IH), 7.39 (d, 2H), 7.70-7.77 (m, 3H), 7.89 (dd, IH), 7.93-8.02 (m, 3H), 8.12 (d, IH), 8.24 (s, IH), 8.53 (d, IH), 8.55 (t, IH). Example 315 N-((4'-fluoro- 1.1 '-biphenyl-4-yP carbonyl)-4-((( 1 S)-3-morphoHn-4-yl-3-oxo- 1 - ((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide Example 315A (3S)-3-((4-(amLinosulfonyP-2-mtrophenyPamino)-4-(phenylthio)butanoic acid The desired product was prepared by substituting Fmoc-L-Asp(OtBu)-OH for Fmoc- D-Asp(OtBu)-OH in Examples 122A-122E. Example 315B 4-(((lS -3-morphoHn-4-yl-3-oxo-l-((phenylthio methyppropyPamino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 315A and morphohne for Example 122E and dimethylamine in Example 122F. Example 315C N-((4'-fluoro-l.l , -biphenyl-4-yl)carbonyP-4-(((lS -3-morphoHn-4-yl-3-oxo-l- ((phenyltMo)methyl)propyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 315B for Example IC in Example ID. MS (ESI(-)) m/e 677 (M-H) " ; 1H NMR (300 MHz, methanol-di) δ 8.79 (d, IH), 8.75 (d, IH), 7.94 (m, 3H), 7.70 (m, 4H), 7.30 (m, 2H), 7.24-7.13 (m, 5H), 7.01 (d, IH), 4.50 (m, IH), 3.62-3.52 (m, 4H), 3.52-3.46 (m, 4H), 3.37 (m, 2H), 3.00 (dd (IH), 2.85 (dd, IH). Example 316 N-(4-(2-(hvdroxymethyl)-3-methyl-l-benzothien-5-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide A mixture of Example 351E (40 mg, 0.063 mmol) andNaBH- 4 (20 mg) in methanol at room temperature was stirred for 10 minutes and concentrated. The concentrate was purified by flash column chromatography on sUica gel with ethyl acetate to provide the desired product. MS (ESI(-)) m/e 632 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 2.38 (s, 3H), 3.19 (t, 2H), 3.60 (m, IH), 4.05 (m, IH), 4.76 (d, 2H), 5.08 (m, IH), 6.99 (d, IH), 7.16 (m, IH), 7.21 (dd, IH), 7.31 (dd, 2H), 7.39 (dd, 2H), 7.66 (m, IH), 7.71 (d, IH), 7.87 (d, 2H), 7.97 (dd, 3H), 8.51 (dd, IH), 8.52 (d, IH). Example 317 N-(4-(l-(moι hoHn-4-ylcarbonyl)-l,2,3,6-tett-ihydropyridin-4-yPbenzoyP-3-nitro-4-((2- (phen lthio) ethyl) amino)benzenesulfonamide A mixture of Example 340A (50 mg, 0.08 mmol), 4-morphoHnecarbonyl chloride (15 mg, 0.012 mmol), and N,N-dUsopropylethylamine (0.07 mL, 0.4 mmol) in dichloromethane (0.5 mL) at room temperature was stirred for 16 hours and concentrated. The concentrate was dissolved in 1 : l/DMSO:methanol (1.0 mL) and purified by reverse phase preparative HPLC using 20-95% acetonitrile/0.1 % TFA to provide the desired product. MS (ESI(-)) m/e 650 (M-H) " ; ! H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.55 (d, 2H), 7.40-7.15 (m, 6H), 6.35 (m, IH), 3.92 (d, 2H), 3.70 (m, 2H), 3.60 (t, 4H), 3.40-3.25 (m, 6H), 3.15 (t, 4H), 2.79 (s, 3H), 3.10-2.70 (m, 4H), 2.65 (t, 2H). Example 318 N-(4-( 1 ,4-dioxa-8-azaspiro(4.5)dec-8-yl)benzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 318A 4-( 1 ,4-dioxa-8-azaspiro(4.5)dec-8-yl)benzoic acid The desired product was prepared by substituting Example 158A for Example 119B in Example 119C. MS (DCI) m/e 264 (M+H) + . Example 318B N-(4-(l,4-dioxa-8-azaspiro(4.5)dec-8-yPbenzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 318A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 599 (M+H) + ; 1HNMR (300 MHz, CDC1 3 ) δ 8.88 (d, IH), 8.67 (t, IH), 8.55 (s, IH), 8.15 (dd, IH), 7.64 (d, 2H), 7.41 (dd, 2H), 7.30 (m, 2H), 6.86 (d, 2H), 6.82 (d, 2H), 3.99 (s, 4H), 3.57 (m, 2H), 3.50 (t, 4H), 3.21 (t, 2H), 1.78 (t, 4H). Example 319 N-(4-(2,8-bis(trifluoromethyPquinolin-4-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide A solution of Example 214D (100 mg, 0.15 mmol) and 2, 8-bistrifluoromethyl-3- chloroquinohne (100 mg, 0.343 mmol) in dioxane (2 mL) was treated with Pd 2 (dba) 3 (10 mg, 0.011 mmol), P(t-Bu) 3 (20 mg, 0.1 mmol) and Cs 2 CO 3 (150 mg, 0.50 mmol), purged with argon, sealed, and heated to 85 °C for 18 hours. The mixture was concentrated and the concentrate was dissolved in 1: 1 DMSO/methanol (1 mL) and filtered. The filtrate was purified by preparative HPLC (using a Nova-Pak HR C-18 column and a solvent system varying in gradient from 10-95% acetonitrUe/water containing 0.1% TFA) to provide the desired product. MS (ESI(+)) m/e 721 (M+H) + , m/e 719 (M-H) " ; ! H NMR (500 MHz, DMSO-d 6 ) δ 8.80 (t, IH), 8.67 (d, IH), 8.41 (d, IH), 8.14 (d, IH), 8.12 (d, 2H), 8.08 (s, IH), 7.97 (dd, IH), 7.91 (t, IH), 7.77 (d, 2H), 7.38 (dt, 2H), 7.28 (td, 2H), 7.24 (d, IH), 7.17 (tt, IH), 3.69 (q, 2H), 3.31 (t, 2H). Example 320 3-nitro-N-(4-(2-(3-oxo-3-piperidin-l-ylpropyP-l,3-benzothiazol-5-ypbenzoyP-4-((2- (phenylthio)ethvPamino)benzenesulfonamide Example 320A tert-butyl 3-(5-bromo- 1 ,3-benzothiazol-2-vPpropanoate The desired product was prepared by substituting tert-butyl bromoacetate for aUyl bromide in Example 213 A. Example 320B 3-(5-bromo-l ,3-benzothiazol-2-yl)propanoic acid The desired product was prepared by substituting Example 320A for Example 201G in Example 20 IH Example 320C 5-bromo-2-(3-oxo-3-piperidin-l-ylpropyl)-1.3-benzothiazole The desired product was prepared by substituting Example 320B and piperidine for Example IB and Example IC, respectively, in Example ID. Example 320D 4-(2-(3-oxo-3-piperidin-l-ylpropyl)-l,3-benzothiazol-5-yl)benzoic acid The desired product was prepared by substituting Example 320C for 6-bromoindole in Example 4A. Example 320E 3-mϊro-N-(4-(2-(3-oxo-3-piperidin-l-ylpropyP-l,3-benzothiazol-5-yl)beιιzovP-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 320D and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 728, 730 (M- H) " (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.42 (t, 2H), 1.55 (tt, 4H), 2.93 (t, 2H), 3.28 (t, 2H), 3.36 (t, 2H), 3.44 (t, 4H), 3.61 (dt, 2H), 7.01 (d, IH), 7.19 (t, IH), 7.31 (t, 2H), 7.39 (d, 2H), 7.73 (d, 3H), 7.89 (dd, IH), 7.98 (d, 2H), 8.10 (d, IH), 8.19 (s, IH), 8.52 (d, IH), 8.54 (t, IH). Example 321 N-(4-(3-(cyanomethyl)-l-benzothien-5-yPbenzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 321 A methyl 4-(3-(cyanomethyP-l-benzothien-5-yl)benzoate The desired product was prepared by substituting 3-cyanomethyl-5- chlorobenzthiophene for 5-chloro-2-methyl-l,3-benzoxazole in Example 54A. MS (ESI(+)) m/e 308 (M+H) + . Example 32 IB 4-(3-(cyanomethyl)-l-benzothien-5-yPbenzoic acid The desired product was prepared by substituting Example 321 A for Example 1 A in Example IB. MS (ESI(-)) m/e 292 (M-H) " . Example 32 IC N-(4-(3-(cyanomethyl)-l-benzothien-5-vPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 321B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 627 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 3.29 (m, 2H), 3.61 (m, 2H), 4.04 (m, IH), 4.40 (s, 2H), 6.99 (d, IH), 7.21 (dd, IH), 7.31 (dd, 2H), 7.40 (d, 2H), 7.54 (dd, 2H), 7.56 (d, IH), 7.91 (d, IH), 8.02 (d, 2H), 8.10 (d, IH), 8.19 (s, IH), 8.52 (m, 2H). Example 322 N~2~-(2-nitro-4-(((4-( 1 -pentyl- 1 H-pyrazol-4-yPbenzoyl)amino)sulfonyl)phenyP- N~l~.N~l~-bisr4-(N-(2-nitro-4-(((4-(l-pentyl-lH-pyrazol-4- yPbenzoyPamino)sulfonyl)phenyP-S-phenylcysteinyl)morphoHn-3-yl)-S- phenylcysteinamide Example 322A 4-iodo- 1 -pentyl- 1 H-pyrazole The desired product was prepared by substituting 1-iodopentane for 1-bromooctane in Example 198A. MS (ESI(+)) m/e 265 (M+H) + Example 322B 4-( 1 -pentyl- 1 H-pyrazol-4-yPbenzoic acid The desired product was prepared by substituting Example 322A for 6-bromoindole in Example 4A. MS (ESI(-)) m/e 257 (M-H) " . Example 322C N~2 — (2-nitro-4-(((4-(l-pentyl-lH-pyrazol-4-ypbenzovPamino)sulfonyl)phenyl)- N~l~,N~l~-bis(4-(N-(2-nitro-4-(((4-(l-pentyl-lH-pyrazol-4- vPbenzovPamino)sulfonyPphenyP-S-phenylcysteinypmorphoUn-3-yl)-S- phenylcysteinamide The desired product was prepared by substituting Example 322B and Example 180B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 705 (M-H) " ; aT NMR (300 MHz, DMSO-d 6 ) δ 0.88 (t, 3H), 1.28 (m, 4H), 1.80 (m, 2H), 3.19 (dd, IH), 3.51 (m, 4H), 3.59 (m, 4H), 3.69 (dd, IH), 4.10 (t, 2H), 5.30 (m, IH), 7.18 (m, 4H), 7.27 (d, 2H), 7.51 (m, 2H), 7.89 (m, 4H), 8.20 (dd, IH), 8.49 (dd, IH), 8.95 (d, IH). Example 323 N-(4-(2-(4-acetylpiperazin-l-yPquinoHn-8-yPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide A solution of 1-acetylpiperazine (100 mg, 0,80 mmol), Example 336E (30 mg, 0.08 mmol), and triethyl amine (100 μL) in DMSO (0.5 mL) was heated tol20 °C for 18 hours, dUuted with methanol (0.5 mL), and purified by preparative HPLC (using a Nova-Pak HR C- 18 column and a solvent system increasing in gradient from 10-95% acetonitrile/water containing 0.1%) to provide the desired product. MS (ESI) m/e 711, 709 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-de) δ 8.78 (t, IH), 8.65 (d, IH), 8.14 (d, IH), 7.97 (d, 2H), 7.95 (d, IH), 7.86 (d, 2H), 7.77 (dd, IH), 7.64 (dd, IH), 7.38 (dt, 2H), 7.33 (td, IH), 7.29 (d, IH), 7.28 (td, 2H), 7.23 (d, IH), 7.17 (tt, IH), 3.69 (q, 2H), 3.67-3.50 (m, 8H), 3.31 (t, 2H), 2.02 . (s, 3H). Example 324 N-(4-(lH-indol-4-yl)benzoyP-3-nitro-4-((2-(phenylthio)ethyl)amino)benzenesulfonamide Example 324A methyl 4-(lH-indol-4-yl)benzoate The desired product was prepared by substituting 4-bromoindole for Example 5A in Example 5B. Example 324B 4-(lH-indol-4-yl)benzoic acid The desired product was prepared by substituting Example 324A for Example 1 A in Example IB. Example 324C N-(4-(lH-indol-4-yl)benzoyp-3-nitro-4-((2-(phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 324B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 571 (M-H) " ; 1H NMR (400 MHz, methanol-d 4 ) δ 8.81 (d, IH), 8.02 (dd, IH), 7.96 (d, 2H), 7.78 (d, 2H), 7.40 (m, 2H), 7.31 (d, IH), 7.25-7.10 (m, 4H), 7.06 (d, IH), 6.59 (d, IH), 3.68 (q, 2H), 3.27 (t, 2H). Example 325 2-methoxyethyl 4-(4-((((3-nitro-4-((2- (phenylthio)ethyl)amino)phenyl)sulfonyl)amino)carbonyl)phenyl)piperazine-l-carboxylate A solution of Example 173 A (54.1 mg, 0.1 mmol) in pyridine (2 mL) and triethylamine (1 mL) at room temperature was treated with 2-methoxyethyl chloroformate (0.2 mmol), stirred for 18 hours, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 0-5% methanol/dichloromethane) to provide the desired product. MS (ESI(-)) m/e 642 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.66 (t, IH), 8.55 (d, IH), 7.89 (dd, IH), 7.75 (d, 2H), 7.30-7.40 (m, 2H), 7.31-7.25 (m, 2H), 7.21- 7.07 (m, 2H), 6.90 (d, 2H), 4.16-4.12 (m, 2H), 3.63 (q, 2H), 3.54-3.43 (m, 4H), 3.31-3.20 (m, 8H), 3.23 (s, 3H). Example 326 N-(4-(3-formyl- 1 -benzothien-5-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 326A (5-chloro-l-benzothien-3-yl)methanol A solution of 3-bromomethyl-5-chlorobenzothiophene (2.5 g, 9.56 mmol) and potassium acetate (1.96 g, 20 mmol) in IM NaOH (40 mL) and dioxane (40 mL) was heated to reflux for 24 hours, adjusted to pH <7 with IM HCl, and extracted with ethyl acetate (3 x). The combined extracts were washed with brine, concentrated, and purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. Example 326B methyl 4-(3-(hvdroxymethyP- 1 -benzothien-5-yl)benzoate The desired product was prepared by substituting Example 326A for 5-chloro-2- methyl-l,3-benzoxazole in Example 54A. MS (ESI(+)) m e 299 (M+H) + . Example 326C methyl 4-(3-formyl-l-benzothien-5-ypbenzoate A solution of Example 326B (298 mg, 1 mmol) and Dess-Martin periodinane (466 mg, 1.1 mmol) in dichloromethane at room temperature was stirred for 90 minutes and purified by flash chromatography on silica gel with 20% ethyl acetate/hexanes to provide the desired product. MS (ESI(+)) m/e 297 (M+H) + . Example 326D 4-(3-formyl-l-benzothien-5-yl)benzoic acid The desired product was prepared by substituting Example 326C for Example 1 A in Example IB. MS (ESI(-)) m/e 281 (M-H) " . Example 326E N-(4-(3-formyl- 1 -benzothien-5-yPbenzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 326D and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 616 (M-H) " ; al NMR (300 MHz, DMSO-d 6 ) δ 3.29 (m, 2H), 3.69 (m, 2H), 4.00 (m, IH), 7.19 (dd, 2H), 7.21 (dd, IH), 7.30 (dd, 2H), 7.38 (d, 2H), 7.85 (m, 3H), 7.95 (dd, IH), 8.01 (d, 2H), 8.24 (d, IH), 8.51 (d, IH), 8.79 (dd, IH), 8.82 (d, IH), 9.02 (s, IH). Example 327 N-(5-(4-clUorophenyl)-2-furoyP-3-nitro-4-((2-(phenyltMo)ethyPamino)benzenesulfonamide The desired product was prepared by substituting 5-(4-chlorophenyl)-2-furoic acid and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(- )) m/e 556 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.52 (t, IH), 7.88 (dd, IH), 7.75 (d, 2H), 7.49 (d, 2H), 7.41-7.39 (m, 2H), 7.33-7.29 (m, 2H), 7.22-7.18 (m, IH), 7.01-6.98 (m, 3H), 6.89 (d, IH), 3.63-3.59 (m, 2H), 3.31-3.20 (m, 2H). Example 328 N-((2'-methoxy-4'-(2-(4-methylpiperazin- 1 -yl)-2-oxoethyP- 1 , 1 '-biphenyl-4-yl)carbonyP-3- nitro-4-((2-(phenyltMo)ethyl)amino)benzenesulfonamide Example 328A methyl 4'-(2,2-dibromovinvP-2'-methoxy-l , 1 '-biphenyl-4-carboxylate A solution of Example 1221 (1.35 g, 5.0 mmol) in dichloromethane (30 mL) at room temperature was treated with carbon tetrabromide (1.82 g, 5.5 mmol) and triphenylphosphine (2.88 g, 11 mmol), stirred for 1 hour, treated with hexanes (50 mL), and filtered through silica gel (50 g). The solution was rinsed with 1 : 1 water/dichloromethane, separated, and the organic phase was concentrated. The concentrate was purified by flash column chromatography on silica gel with 2-10% ethyl acetate/hexanes to provide the desired product. Example 328B methyl 2'-methoxy-4'-(2-(4-methylpiperazin- 1 -yl)-2-oxoethyP- 1 , 1 '-biphenyl-4-carboxylate A mixture of Example 328A (213 mg, 0.5 mmol), 1-methylpiperazine (2.5 mmol), and bis(tricyclohexylphosphine)palladium chloride (0.0025 mmol) in DMF (1.5 mL) and water (0.25 mL) was heated to 80 °C for 8 hours, diluted with ethyl acetate (100 mL), washed with water (45 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 2-10% methanol/dichloromethane to provide the desired product. Example 328C N-((2'-methoxy-4'-(2-(4-methylpiperazin-l-yl)-2-oxoethyP-l.l'-biphenyl-4-yl)carbonvP-3- nitro-4-(/2-(pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 328B and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 702 (M-H) " ; l H NMR (500 MHz, DMSO-d 6 ) δ 8.78 (t, IH), 8.63 (d, IH), 7.93 (dd, IH), 7.90 (d, 2H), 7.59 (d, 2H), 7.36 (m, 2H), 7.27 (m, 3H), 7.22 (d, IH), 7.19 (tt, IH), 6.99 (d, IH), 6.90 (dd, IH), 3.82 (s, 2H), 3.75 (s, 3H), 3.68 (q, 2H), 3.29 (t, 4H), 2.82 (s, 3H), remAining 6 protons are buried under very broad water peak (3.60-3.30 ppm). Example 329 4-((2-morphohn-4-yl- 1 -((phenylthio)methyP ethyl) amino) -3 -nitro-N-(4-( 1 -pentyl- 1 H- pyrazol-4-yl)benzoyl)benzenesulfonamide The desired product was prepared by substituting Example 322B and racemic Example 146C for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 691 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 0.86 (t, 3H), 1.28 (m, 4H), 1.79 (m, 2H), 2.38 (m, 2H), 2.44 (m, 2H), 2.62 (d, 2H), 3.40 (dd, IH), 3.52 (m, 4H), 3.59 (m, 4H), 3.69 (dd, IH), 4.02 (m, IH), 4.09 (t, 2H), 4.16 (m, IH), 5.30 (m, IH), 6.98 (d, IH), 7.12 (dd, IH), 7.21 (dd, 2H), 7.32 (d, 2H), 7.52 (m, 2H), 7.86 (m, 4H), 8.21 (s, IH), 8.36 (d, IH), 8.48 (s, IH). Example 330 3-(5-(4-((((4-((l-adamantylmethyl)amino)-3-nitrophenyPsulfonypamino carbonyl)phenvP- 1 ,3 -benzothiazol-2-yl)-N-butylpropanamide Example 330A 3-(5-bromo-l,3-benzothiazol-2-yP-N-butylpropanamide The desired product was prepared by substituting Example 320B and butylamine for Example IB and Example IC, respectively, in Example ID. Example 330B 4-(2-(3-(butylamino)-3-oxopropyP- 1.3-benzothiazol-5-yl)benzoic acid The desired product was prepared by substituting Example 330A for 6-bromoindole in Example 4A. Example 330C 3-(5-(4-((((4-((l-adamantylmethyPamino -3-nitrophenyPsulfonyl)amino)carbonyPphenyP- l,3-benzothiazol-2-yl)-N-butylprop-mamide The desired product was prepared by substituting Example 330B and Example 28A for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 728, 730 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.82 (t, 3H), 1.25 (m, 2H), 1.35 (tt, 2H), 1.55-1.73 (m, HH), 1.97 (m, 2H), 2.65 (t, 2H), 3.04 (dt, 2H), 3.12 (d, 2H), 3.33 (t, 2H), 7.16 (d, IH), 7.71 (d, 2H), 7.73 (d, IH), 7.90 (dd, IH), 7.93 (t, IH), 7.98 (d, 2H), 8.10 (d, IH), 8.18 (s, IH), 8.38 (t, IH), 8.54 (d, IH). Example 331 N-(4-(2-(hydroxymethyl)quinolin-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide A mixture of Example 339B (10 mg) and sodium borohydride (4 mg) in methanol (1 mL) was stirred at room temperature for 4 hours, diluted with ethyl acetate (30 mL), washed with water (5 mL) and brine (5 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with ethyl acetate to provide the desired product. MS (ESI(-)) m/e 613 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.77 (d, 2H), 8.33 (d, IH), 8.09 (d, 2H), 8.00 (dd, IH), 7.91 (dd, IH), 7.75 (dd, IH), 7.69 (d,H), 7.51 (m, 2H), 7.39 (m, 2H), 7.23 (t, 2H), 7.18 (ttt, IH), 6.94 (d, IH), 4.75 (s, 2H), 3.62 (m, 2H), 3.24 (t, 2H). Example 332 N-((6-(4-fluorophenyppyridin-3-vPcarbonyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 77B and Example 298B for Example 124E and Example 257C, respectively, in Example 124F. MS (ESI) m/e 553, 551 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 9.07 (d, IH), 8.78 (t, IH), 8.64 (d, IH), 8.30 (dd, IH), 8.22 (q, 2H), 8.10 (d, IH), 7.95 (dd, IH), 7.38-7.16 (m, 8H), 3.67 (q, 2H), 3.29 (t, 2H). Example 333 N-(4-(3 , 5-dimethyl- 1 -pentyl- 1 H-pyrazol-4-vPbenzovP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 333 A 4-bromo-3 , 5-dimethyl- 1 -pentyl- 1 H-pyrazole The desired product was prepared by substituting 5-iodopentane and 4-bromo-3,5- dimethylpyrazole for 1-bromooctane and 4-iodopyrazole, respectively, in Example 198A. MS (ESI(+)) m/e 245, 247 (M+H) + . Example 333B 4-(3 , 5-dimethyl- 1 -pentyl- 1 H-pyrazol-4-ypbenzoic acid The desired product was prepared by substituting Example 333 A for 6-bromoindole in Example 4A. MS (ESI(-)) m/e 285 (M-H) " . Example 333C N-(4-(3 , 5-dimethyl- 1 -pentyl- 1 H-pyrazol-4-yPbenzoyP-3 -nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 333B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 620 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.89 (t, 3H), 1.30 (m, 4H), 1.71 (tt, 2H), 2.11 (s, 3H), 2.21 (s, 3H), 3.27 (t, 2H), 3.61 (q, 2H), 3.96 (t, 2H), 4.39 (m, IH), 6.99 (d, IH), 7.19 (d, IH), 7.20 (dd, 2H), 7.31 (dd, 2H), 7.40 (d, 2H), 7.89 (dd, IH), 7.90 (d, 2H), 8.51 (d, IH), 8:52 (t, IH). Example 334 3-nitro-4-((2-(phenylt o)ethyPamino)-N-(4-quinolin-2-ylbenzoyPbenzenesulfonamide The desired product was prepared by substituting 2-chloroquinoline and Example 108 A for 4-bromo-l-iodobenzene and Example 3C, respectively, in Example 3D. MS (ESI(- )) m/e 583 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.55 (d, IH), 8.52 (t, IH), 8.44 (d, IH), 8.23 (d, 2H), 8.17 (d, IH), 8.08 (d, IH), 8.05 (d, 2H), 8.00 (d, IH), 7.90 (t, IH), 7.78 (dt, IH), 7.60 (m, 2H), 7.40 (dd, IH), 7.30 (t, 2H), 7.20 (tt, IH), 7.00 (d, IH), 3.63 (q, 2H), 3.26 (t, 2H). Example 335 N-(4-(2-methyl-l,3-benzothiazol-5-yPbenzoyl)-4-((2-morphoHn-4-yl-l- ((phenylthio)methyPethyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 17 A and Example 245 A for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 704 (M+H) + ; 1H NMR (400 MHz, methanol-d 4 ) δ 8.68 (d, IH), 8.10 (m, 3H), 7.96 (d, IH), 7.91 (dd, IH), 7.68 (m, 3H), 7.32 (m, 2H), 7.13 (m, 3H), 6.93 (d, IH), 4.11 (m, IH), 3.63 (t, 4H), 3.39 (dd, IH), 3.21 (dd, IH), 2.84 (s, 3H), 2.49 (m, 4H). Example 336 N-(4-(2-chloroquinoUn-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 336A 2-hydroxyquinolin-8-yl trifluoromethanesulfonate A mixture of 2,8-quinohnediol (4.23 g, 26.3 mmol), 2-(N,N- bis(trifluoromethylsulfonyl)amino)pyridine(9.4 g, 26.3 mmol) and dusopropylethylamine (14 mL, 80.5 mmol) in dichloromethane (50 mL) at room temperature was stirred for 18 hours, dUuted with ethyl acetate (200 mL), washed with water (2 x 50 mL) and brine (50 mL), dried filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 1 :4 ethyl acetate/hexanes to provide the desired product. MS (APCI) m/e 292 (M-H) " . Example 336B methyl 4-(2-hy dr oxy quinolin-8 -ypbenzoate A mixture of Example 336A (2.93 g, 10 mmol), 4-(methoxycarbonyl)phenylboronic acid (1.80 g, 10 mmol), Pd(Ph 3 P) 4 (0.346 g, 0.3 mmol), and CsF(1.52g, lOmmoi) in DME (60 mL) and methanol (30 mL) was heated to reflux for 18 hours and concentrated. The concentrate was dissolved in water (50 mL) and ethyl acetate (300 mL) and the organic phase was washed with water (2 x 50 mL) and brine (50 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 4: 1 hexanes/ethyl acetate to provide the desired product. MS (APCI) m/e 280, 278 (M+H) + , (M-H) " . Example 336C methyl 4-(2-chloroquinoHn-8-yl)benzoate A mixture of Example 336B (1.76 g, 6.3 mmol) in POCl 3 (50 mL) was heated to reflux for 30 minutes and concentrated. The concentrate was purified through a sUica gel pad with 4: 1 hexanes/ethyl acetate to provide the desired product. MS (ESI) m/e 298( M+H) . Example 336D 4-(2-chloroquinoHn-8-yl)benzoic acid The desired product was prepared by substituting Example 336C for Example 1 A in Example IB. MS (ESI) m e 284 (M+H) + . Example 336E N-(4-(2-chloroquinoUn-8-yPbenzoyP-3-nitro-4-((2- (phenylthio ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 336C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 617 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.77 (t, IH), 8.54 (d,2H), 8.52 (d, IH), 8.11 (dd, IH), 7.97 (d, 2H), 7.90 (dd, IH), 7.87 (dd, IH), 7.75 (m, 3H), 7.63 (d, IH), 7.37 (m, IH), 7.27 (tt, 2H), 7.21 (d, IH), 7.19 (t, IH), 3.67 (q, 2H), 3.28 (t, 2H). Example 337 3-nitro-N-(4-((E -2-ρhenylethenyl)benzovP-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 337A methyl 4-((E)-2-phenylethenyl)benzoate The desired product was prepared by substituting beta-styryl boronic acid for 4- fluorophenylboronic acid in Example 1 A. MS (ESI(-)) m/e 237 (M-H) " . Example 337B 4-((E)-2-phenylethenyl)benzoic acid- The desired product was prepared by substituting Example 337A for Example 1 A in Example IB. MS (ESI(-)) m/e 223 (M-H) " . Example 337C 3-nitro-N-(4-((E)-2-phenylethenyl)benzoyp-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 337B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 558 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 3.27 (t, 2H), 3.61 (t, 2H), 4.01 (m, IH), 6.99 (d, IH), 7.20 (d, IH), 7.27 (d, 2H), 7.29 (d, 2H), 7.34 (d, IH), 7.39 (s, IH), 7.40 (d, 2H), 7.54 (d, 2H), 7.61 (d, 2H), 7.88 (d, 2H), 7.89 (d, 2H), 8.51 (d, IH), 8.52 (t, IH). Example 338 tert-butyl 3-((4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyPamino)sulfonyl)-2- nitrophenyl)amino)-4-(phenylthio)butanoate Example 338 A tert-butyl 3-((4-(aminosulfonyl)-2-nitrophenyl)amino)-4-(phenylthio)butanoate The desired product was prepared by substituting Fmoc-DL-Asp(OtBu)-OH for Fmoc-D-Asp(OtBu)-OH in Examples 122A-122D. Example 338B tert-butyl 3-((4-((((4'-fluoro- 1 , 1 '-biphenyl-4-vPcarbonyl)amino)sulfonyP-2- nitrophenyl)amino)-4-(phenylthio)butanoate The desired product was prepared by substituting Example 338A for Example IC in Example ID. MS (ESI(-)) m/e 664 (M-H) " ; H NMR (300 MHz, methanol-d 4 ) δ 8.73 (d, IH), 8.58 (d, IH), 7.95 (dd, IH), 7.93 (d, 2H), 7.70 (m, 4H), 7.28 (m, 2H), 7.23-7.12 (m, 5H), 6.98 (d, IH), 4.40 (m, IH), 2.78 (m, 2H), 1.36 (s, 9H), and remaining two protons are buried under solvent peaks (3.35-3.28 ppm). Example 339 N-(4-(2-formylquinolin-8-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 339A 2-formylquinolin-8-yl trifluoroacetate The desired product was prepared by substituting 8-hydroxyquinoline-2- carboxaldehyde for vanilhn in Example 122H. Example 339B N-(4-(2-formylquinolin-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 339A for Example 389A in Example 389B. MS (ESI(-)) m/e 611 (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 9.97 (s, IH), 8.66 (d, IH), 8.54 (d, IH), 8.52 (t, IH), 8.12 (dd, IH), 8.02 (d, 2H), 7.95 (s, IH), 7.93 (dt, IH), 7.87 (dd, IH), 7.72 (d, 2H), 7.41 (td, 2H), 7.32 (t, 2H), 7.21 (tt, IH), 7.01 (d, IH), 3.62 (q, 2H), 3.28 (t, 2H). Example 340 3-nitro-4-((2-(phenylthio)ethvPamino)-N-(4-(l-(;pyridin-3-ylmethyP-1.2.3.6- tetrahydropyridin-4-yPbenzoyl)benzenesulfonamide Example 340A N-((3-nitro-4-((2-(phenylsulfanyl)ethyl)amino)phenyPsulfonyP-4-(l,2,3,6-tetrahydropyridin- 4-yl)benzamide A room temperature mixture of Example 455C in TFA (10 mL) and dichloromethane (10 mL) was stirred for 30 minutes and concentrated to provide the desired product. MS (ESI(+)) m/e 539 (M+H) + . Example 340B 3-nitro-4-(;(2-(phenylthio)ethvPamino)-N-(4-(l-(pyridin-3-ylmethvP-1.2.3.6- tetrahydropyridin-4-yl)benzoypbenzenesulfonamide A mixture of Example 340A (65 mg, 0.1 mmol), NaBH CN (48 mg, 0.75 mmol), 2N NaOH (0.15 mL), and 3-pyridinecarboxaldehyde (214 mg, 2 mmol) in acetic acid (0.5 mL) and methanol (1 mL) was stirred for 16 hours. The reaction mixture was concentrated, dissolved in 1 : 1 DMSO/methanol (1.0 mL) and purified by reverse phase preparative HPLC using 20-90% acetonitrUe/water containing 0.1 % TFA to provide the desired product. MS (ESI(-)) m/e 628 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.70 (d, IH), 8.70 (dd, IH), 8.60 (d, IH), 8.05 (m ,lH), 7.95 (d, 2H), 7.62 (d, 2H), 7.60 (dd, IH), 7.40-7.15 (m, 6H), 6.35 (m, IH), 4.52 (d, 2H), 3.92 (m, 4H), 3.45 (t, 4H), 2.82 (m, 2H). Example 341 3-(5-(4-((((3-nitro-4-((2-(phenylthio)ethyl)amino)phenyPsulfonyl)amino)carbonyl)phenyl)- l,3-benzothiazol-2-vP-N-(thien-2-ylmethyPpropanamide The desired product was prepared by substituting thiophene-2-methylamine for piperidine in Example 320. MS (ESI) m/e 756, 758 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 2.18 (t, 2H), 2.74 (t, 2H), 3.28 (t, 2H), 3.63 (dt, 2H), 4.44 (d, 2H), 6.88-6.95 (m, 2H), 7.08 (d, IH), 7.19 (t, 2H), 7.29 (t, 2H), 7.35 (dd, IH), 7.39 (d, 2H), 7.75 (dd, IH), 7.78 (d, 2H), 7.92 (dd, IH), 7.99 (d, 2H), 8.12 (d, IH), 8.21 (s, IH), 8.56 (d, IH), 8.58-8.65 (m, 2H). Example 342 N-(4-(4-methylpyridin-2-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting 2-chloro-4-methylpyridine for 2,8- bistrifluoromethyl-3-chloroquinoHne in Example 319. MS (ESI) m/e 549, 547 (M+H) + , (M- H) " ; 1H NMR (500 MHz, DMSO-de) δ 8.78 (t, IH), 8.64 (d, IH), 8.54 (d, IH), 8.19 (d, 2H), 7.98 (d, 2H), 7.94 (dd, IH), 7.92 (d, IH), 7.37 (dt, 2H), 7.27 (td, 2H), 7.25 (dd, IH), 7.22 (d, IH), 7.17 (tt, IH), 3.67 (q, 2H), 3.29 (t, 2H), 2.40 (s, 3H). Example 343 N-(4-(2-butyl- 1 -cyclopentyl- 1 H-benzimidazol-5-yl)benzoyl) -3 -nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 343A 4-bromo-N -cyclopentylbenzene-1 ,2-diamine The desired product was prepared by substituting cyclopentylamine for butylamine in Examples 166A and 166B. Example 343B 5-bromo-2-butyl- 1 -cyclopentyl- 1 H-benzimidazole Valeric acid (8 mL) and Example 343 A (250 mg, 0.98 mmol) was heated to 1 0 °C for 18 hours, treated with IM NaOH (10 mL), extracted with ethyl acetate (3 x 50 mL), washed with brine (10 mL), dried (Na 2 SO 4 ), filtered, and concentrated to provide the desired product. Example 343 C N-(4-(2-butyl-l-cyclopentyl-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino benzenesulfonamide The desired product was prepared by substituting Example 343B and Example 214E for 6-bromoindole and 4-(dihydroxyboryl)benzoic acid, respectively, in Example 4A. MS (ESI(+)) m/e 698 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.95 (t, 3H), 1.43 (dt, 2H), 1.76 (m, 4H), 2.00 (m, 2H), 2.11 (m, 4H), 2.94 (t, 2H), 3.27 (t, 2H), 3.62 (dt, 2H), 4.93 (tt, IH), 7.04 (d, IH), 7.19 (t, IH), 7.30 (t, 2H), 7.39 (d, IH), 7.45-7.64 (m, 4H), 7.69 (d, 2H), 7.90 (dd, IH), 7.95 (d, 2H), 8.54 (d, IH), 8.58 (t, IH). Example 344 N-(4-(6-chloropyrazin-2-yl)benzoyP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting 2,6-dichloropyrazine for 2,8- bistrifluoromethyl-3-chloroquinohne in Example 319. MS (ESI(+)) m/e 570, 568 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 9.35 (s, IH), 8.81 (s, IH), 8.78 (t, IH), 8.64 (d, IH), 8.24 (d, 2H), 8.04 (d, 2H), 7.94 (dd, IH), 7.37 (dt, 2H), 7.27 (td, 2H), 7.22 (d, IH), 7.17 (tt, IH), 3.68 (q, 2H), 3.29 (t, 2H). Example 345 tert-butyl 5-((4-((((4'-fluoro-l , 1 '-biphenyl-4-yl)carbonyl)amino)sulfonyl)-2- nitrophenvPamino)-6-(phenylthio)hexylcarbamate Example 345A 9H-fluoren-9-ylmethyl l-(hvdroxymethyP-5-(tert-butoxycarbonylamino)pentylcarbamate The desired product was prepared by substituting Fmoc-DL-Lys(BOC)-OH for Fmoc- D-Asp(OtBu)-OH in Example 122A. Example 345B 9H-fluoren-9-ylmethyl l-(phenylthiomethyl)-5-(tert-butoxycaι-bonylamino)pentylcarbamate The desired product was prepared by substituting Example 345A for Example 122A in Example 122B. Example 345C tert-butyl 5-((4-(armnosulfonyl)-2-nitrophenyl)amino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 345B for Example 122B in Example 122D. Example 345D tert-butyl 5-((4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yl)c-irbonyl)amino)sulfonyl)-2- nitrophenyl)amino)-6-(phenylthio)hexylcarbamate The desired product was prepared by substituting Example 345C for Example 1 C in Example ID. MS (ESI(-)) m/e 721 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.48 (d, IH), 8.17 (d, IH), 7.97 (d, 2H), 7.82 (dd, IH), 7.73 (m, 2H), 7.61 (d, 2H), 7.32-7.10 (m, 8H), 4.12 (m, IH), 3.67 (m, 2H), 2.74 (m, 2H), 1.75 (m, 2H), 1.53 (m, 2H), 1.40 (m, 2H) 1.32 (s, 9H). Example 346 ethyl N-(((2-((4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yl)caι-bonyl)amino)sulfonyl)-2- nitrophenyl)-mιino)-3-(phenyltMo)propyP-ιmino)carbonyl)glycmate The desired product was prepared by substituting ethyl isocyanatoacetate for acetyl chloride in Example 310. MS (ESI(-)) m/e 708 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.59 (d, IH), 8.42 (d, IH), 7.97 (d, 2H), 7.87 (dd, IH), 7.78 (m, 4H), 7.35-7.10 (m, 7H), 6.55 (t, IH), 6.29 (t, IH), 4.34 (m, IH), 4.02 (q, 2H), 3.72 (d, 2H), 3.37 (m, 2 H, 1.17 (t, 3H), and remaining protons (4) are buried under solvent peaks. Example 347 methyl 5-ethyl-2-(;4-(;((;(3-nitro-4-((2- (phenyltMo)ethyl)amino)phenyPsulfonyl)amino)carbonyPphenyl)-l,3-thiazole-4-carboxylate Example 347A 4-(5-ethyl-4-(methoxycarbonyl)-l ,3-thiazol-2-yl)benzoic acid The desired product was prepared by substituting methyl 2-bromo-5-ethylthiazole-4- carboxylate (prepared according to the procedure described in J. Chem. Soc. Perkin 11982, 159- 164) for 6-bromoindole in Example 4A. Example 347B methyl 5-ethyl-2-(4-((((3-nitro-4-((2- (phenyltMo)ethyl)amino)phenypsu The desired product was prepared by substituting Example 347A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 625, 627 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.31 (t, 3H), 3.25 (t, 2H), 3.28 (q, 2H), 3.62 (dt, 2H), 3.86 (s, 3H), 7.03 (d, IH), 7.19 (t, IH), 7.30 (t, 2H), 7.39 (d, 2H), 7.88 (d, 2H), 7.99 (d, 2H), 8.54 (d, IH), 8.56 (t, IH). Example 348 N.N-dimethyl-4-(4-((f(3-mtro-4-((2- sulfonamide Example 348A 4-iodo-N,N-dimethyl- 1 H-pyrazole- 1 -sulfonamide The desired product was prepared by substituting dimethylaminosulfonyl chloride for 1-bromooctane in Example 198A. MS (ESI(-)) m/e 300 (M-H) " . Example 348B 4-(l-((dimethylamino)sulfonyl)-lH-pyrazol-4-yl)benzoic acid The desired product was prepared by substituting Example 348A for 6-bromoindole in Example 4A. MS (ESI(-)) m/e 294 (M-H) " . Example 348C N,N-dimethyl-4-(4-((((3-nitro-4-((2- (phenyltMo)ethyl)-imino)phenyl)sulfonyl)-ιmino)carbonyPphenyl)-lH-pyrazole-l- sulfonamide The desired product was prepared by substituting Example 348B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 629 (M-H) " ; l H NMR (300 MHz, DMSO-d 6 ) δ 2.89 (s, 6H), 3.28 (t, 2H), 3.61 (dt, 2H), 3.64 (dt, 2H), 7.01 (d, IH), 7.20 (t, IH), 7.30 (t, 2H), 7.40 (d, 2H), 7.72 (d, 2H), 7.89 (d, IH), 7.90 (d, 2H), 8.41 (s, IH), 8.51 (d, IH), 8.54 (t, IH), 8.78 (s, IH). Example 349 N-(4-( 1 -cyclopentyl- 1 H-benzimidazol-5-yPbenzoyP-3 -nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 349A 4-bromo-N -cyclopentylbenzene-1 ,2-diamine The desired product was prepared by substituting cyclopentylamine for butylamine in Examples 166A and 166B. Example 349B 5-bromo- 1 -cyclopentyl- 1 H-benzimidazole The desired product was prepared by substituting Example 349A for Example 170A in Example 170B. Example 349C N-(4-(l-cyclopentyl-lH-benzimidazol-5-vPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 349B and Example 214E for 6-bromoindole and 4-(dihydroxyboryl)benzoic acid, respectively, in Example 4A. MS (ESI) m/e 640, 642 (M-H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 1.75 (m, 2H), 1.85- 2.06 (m, 4H), 2.23 (m, 2H), 3.28 (t, 2H), 3.61 (dt, 2H), 4.89 (tt, IH), 6.99 (d, IH), 7.19 (t, IH), 7.31 (t, 2H), 7.38 (d, 2H), 7.53 (dd, IH), 7.56-7.72 (m, 4H), 7.88 (dd, IH), 7.95 (t, 2H), 8.35 (s, IH), 8.53 (t, IH), 8.54 (d, IH). Example 350 3-(5-(4-((((4-((l-adamantylm^ethyl)amino)-3-nitrophenyPsulfonyPamino)carbonyPphenyP- l,3-benzothiazol-2-yP-N-(thien-2-ylmethyPpropanamide Example 350A 3-(5-bromo- 1 ,3-benzothi-ιzol-2-yP-N-(tMen-2-yhnethyPpropanamide The desired product was prepared by substituting Example 320B and thiophene-2- methylamine for Example IB and Example IC, respectively, in Example ID. Example 350B 4-(2-(3-oxo-3-((thien-2-ylmethyl)amino)propyl)- 1 ,3-benzothiazol-5-yl)benzoic acid The desired product was prepared by substituting Example 350A for 6-bromoindole in Example 4A. Example 350C 3 -(5-(4-((((4-(( 1 -adamantylmethyl) amino) -3 -nitrophenyPsulfonyl) amino) carbonyPphenyP- l,3-benzothiazol-2-yl)-N-(thien-2-ylmethyl)propanamide The desired product was prepared by substituting Example 350B and Example 28 A for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 768, 770 (M- H) ' , (M+H) + ; NMR (300 MHz, DMSO-d 6 ) δ 1.54-1.75 (m, 13H), 1.94-2.02 (m, 2H), 3.14 (d, 2H), 3.75 (t, 2H), 4.44 (d, 2H), 6.88-6.96 (m, 2H), 7.16 (d, IH), 7.35 (dd, IH), 7.68-7.76 (m, 3H), 7.89 (dd, IH), 7.98 (d, 2H), 8.11 (d, IH), 8.18 (s, IH), 8.39 (t, IH), 8.53 (d, IH), 8.63 (t, IH). . Example 351 N-(4-(2-formyl-3-methyl-l-benzothien-5-yPbenzoyP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 351 A 5-chloro-3-methyl-2-vinyl-l-benzothiophene A solution of 2-bromo-5-chloro-3-methylbenzthiophene (5 g, 19.1 mmol), vinyltributylstannane (5.59 mL, 19.1 mmol), Pd 2 dba 3 (525 mg, 0.57 mmol), and tri(2- furypphosphine (532 mg, 2.29 mmol) in NMP (70 mL) at 90 °C was stirred for 18 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with hexanes to provide the desired product. MS (ESI(-)) m/e 207 (M-H) " . Example 35 IB methyl 4-(3-methyl-2-vinyl-l-benzothien-5-yl)benzoate The desired product was prepared by substituting Example 351 A for 5-chloro-2- methyl- 1,3-benzoxazole in Example 54A. MS (ESI(+)) m/e 310 (M+H) + . Example 351C methyl 4-(2-formyl-3-methyl-l-benzothien-5-yl)benzoate A mixture of Example 351B (900 mg, 3 mmol), 0.08M OSO 4 in tert-butanol (4 mL) and N-morphoHne-N-oxide (352 mg, 3 mmol) in THF (25 mL) and water (10 mL) at room temperature was stirred for 18 hours and partitioned between water and ethyl acetate. The organic phase was concentrated and the concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate hexanes. A mixture of the purified product (500 mg, 1.5 mmol) and NaIO 4 (500 mg, 2.3 mmol) in 1: 1 TH-F/water (40 mL) at room temperature was stirred for 3 hours, poured into IM HCl, and extracted with ethyl acetate (3 x). The combined extracts were washed with brine and concentrated. Example 35 ID 4-(2-formyl-3 -methyl- 1 -benzothien-5-yl)benzoic acid The desired product was prepared by substituting Example 351C for Example 1 A in Example IB. MS (ESI(-)) m/e 295 (M-H) " . Example 35 IE N-(4-(2-formyl-3-methyl-l-benzothien-5-ypbenzoyP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 35 ID and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m e 630 (M-H) " ; aa NMR (300 MHz, DMSO-d 6 ) δ 2.89 (d, 3H), 3.29 (t, 2H), 3.69 (dt, 2H), 7.19 (m, 2H), 7.26 (dd, 2H), 7.38 (d, 2H), 7.95 (m, 4H), 8.00 (dd, 2H), 8.16 (d, IH), 8.39 (d, IH), 8.63 (d, IH), 8.79 (dd, IH), 10.38 (s, IH). Example 352 N-(4-(4-(cvclohexylcarbonyppiperazin-l-yl)benzoyl)-3-rtitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting cyclohexanoyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-))m/e 650 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.76 (t, IH), 8.59 (d, IH), 7.91 (dd, IH), 7.76 (d, 2H), 7.39-7.34 (m, 2H), 7.29-7.24 (m, 2H), 7.21-7.14 (m, 2H), 6.94 (d, 2H), 3.70-3.56 (m, 4H), 3.32-3.23 (m, 8H), 2.60-2.56 (m, IH), 1.72-1.63 (m, 4H), 1.36-1.17 (m, 6H). Example 353 dimethyl 1 -(2-((4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yPcarbonyl) amino)sulfonyP-2- nitrophenyl) amino) ' -3 -(phenylthio)propyl)- 1 H- 1.2, 3 -triazole-4.5-dicarboxylate A solution of Example 434D (40 mg) and dimethyl acetylenedicarboxylate (lOOmg) in toluene (2 mL) was heated to 90 °C for 16 hours and purified by flash column chromatography on silica gel with 30-100% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 747 (M-H) " ; ! H NMR (300 MHz, DMSO-de) δ 8.45 (d, IH), 8.17 (d, IH), 7.94 (d, 2H), 7.73 (m, 3H), 7.59 (d, 2H), 7.32-7.15 (m, 8H), 5.00 (m, 2H), 4.51(m, IH), 3.80 (s, 3H), 3.75 (s, 3H), 3.45 (m, 2H). Example 354 N-(4-(2-(3 -(4-methylpiperazin- 1 -yl)-3 -oxopropyl) - 1 ,3 -benzothiazol-5-yl)benzoyP-3 -nitro-4- ((2~(pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting 1-methylpiperazine for piperidine in Example 320. MS (ESI) m/e 743, 745 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.43 (s, 3H), 2.68 (m, 4H), 2.97 (t, 2H), 3.17 (d, 2H), 3.27 (t, 2H), 3.38 )t, 2H), 3.61 (m, 4H), 4.44 (d, 2H), 6.99 (d, IH), 7.21 (tt, 2H), 7.32 (t, 2H), 7.40 (dd, 2H), 7.71 (d, IH), 7.74 (dd, IH), 7.88 (dd, IH), 7.98 (d, 2H), 8.10 (d, IH), 8.18 (d, IH), 8.62 (t, IH), 8.63 (d, IH). Example 355 4-((2-adamantylmethyl)amino)-N-(4-(2-aminoquinoUn-8-yPbenzoyl)-3- nitrobenzenesulfonamide Example 355A 2-aminoquinoUn-8-yl trifluoroacetate The desired product was prepared by substituting 2-amino-8-hydiOxyquinoline for vanillin in Example 122H. Example 355B 4-((2-adamantylmethyl)amino)-N-(4-(2-aminoquinoHn-8-yl)benzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 255A and Example 355A for Example 108A and Example 389A, respectively, in Example 389B. MS (ESI(-)) m/e 610 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.73 (d, IH), 8.50 (t, IH), 8.12 (br s, IH), 7.97 (d, 2H), 7.93 (dd, IH), 7.77 (br s, IH), 7.62 (d, 2H), 7.53 (d, IH), 7.32 (br s, IH), 7.30 (d, IH), 6.90 (br s, IH), 3.17 (d, 2H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 356 N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyl)-4-((3-hydroxy- 1 - ((phenyltMo)methvPpropyl)amino)-3-nitrobenzenesulfonamide Example 356A 3-((4-(aminosulfonyP-2-nitrophenyPamino)-4-(phenylthio)butanoic acid The desired product was prepared by substituting Fmoc-DL-Asp(OtBu)-OH for Fmoc-D-Asp(OtBu)-OH in Examples 122A-122E. Example 356B N-((4'-fluoro- 1 , 1 '-biphenyl-4-yP carbonyl)-4-((3-hydroxy- 1 - ((phenylthio)methyl)propyP-mιino)-3-nittobenzenesuιfonamide The desired product was prepared by substituting Example 356A for Example 122E in Example 280. MS (ESI(-)) m/e 594 (M-H) " ; 1H NMR (500 MHz, methanol-d 4 ) δ 8.72 (d, IH), 7.92 (m, 3H), 7.70 (m, 4H), 7.26 (m, 2H), 7.18 (tt, 2H), 7.11 (m, 3H), 7.00 (d, IH), 4.25 (m, IH), 3.68 (m, 2H), 3.39 (d, IH), 3.21 (m, 3H), 2.08 (m, IH), 1,97 (m, IH). Example 357 methyl 4-r4-((;( ' r3-nitro-4- (2- (phenylthio)ethyl)amino)phenyl)sulfonyl)amino)carbonyl)phenyl)-3,6-dihydropyridine- 1 (2H)-carboxylate The desired product was prepared by substituting methyl chloroformate for 4- morphoHnecarbonyl chloride in Example 317. MS (ESI(-)) m/e 595 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.55 (d ; 2H), 7.40-7.15 (m, 6H), 6.35 (m, IH), 4.08 (d, 2H), 3.70 (m, 2H), 3.62 (s, 3H), 3.60 (t, 2H), 3.40- 3.25 (m, 4H). Example 358 N-(4-(4-((benzyloxy)acetvPpiperazin-l-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethvPamino)benzenesulfonamide The desired product was prepared by substituting benzyloxyacetyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 688 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.74 (t, IH), 8.59 (d, IH), 7.90 (dd, IH), 7.76 (d, 2H), 7.39-7.14 (m, HH), 6.94 (d, 2H), 4.52 (s, 2H), 4.24 (s, 2H), 3.66 (q, 2H), 3.70-3.56 (m, 4H), 3.32-3.23 (m, 6H). Example 359 N-(4-(l-(2,2-dimethylprop- oyl)-1.2,3,6-tetrahydropyrid -4-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting trimethylacetyl chloroformate for,4- morphoHnecarbonyl chloride in Example 317. MS (ESI(-)) m/e 621 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.55 (d, 2H), 7.40-7.15 (m, 6H), 6.35 (m, IH), 4.18 (d, 2H), 3.75 (t, 2H), 3.70 (m, 2H), 3.40-3.25 (m, 4H), 1.25 (s, 9H). Example 360 N-f4-(2-((ethylthio)methyP-1.3-benzothiazol-5-vPbenzovP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting diethyl disulfide for aUyl bromide in Example 213. MS (ESI) m/e 663, 665 (M-H) " , (M+H) + ; H NMR (300 MHz, DMSO-de) δ 1.22 (t, 3H), 2.61 (q, 2H), 3.27 (t, 2H), 3.62 (dt, 2H), 4.25 (s, 2H), 7.03 (d, IH), 7.19 (tt, IH), 7.30 (td, 2H), 7.40 (dd, IH), 7.75 (d, 2H), 7.76 (dd, IH), 7.90 (dd, IH), 7.98 (d, 2H), 8.14 (d, IH), 8.23 (d, IH), 8.54 (d, IH), 8.56 (t, IH). Example 361 N-(4-(l-cyclopentyl-2-(2-methoxyethyl)-lH-benzimidazol-5-vPbenzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting 3-methoxypropionic acid for valeric acid in Example 343. MS (ESI) m e 698, 700 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO- de) δ 1.76 (m, 2H), 1.99 (m, 2H), 2.12 (m, 4H), 3.19 (t, 2H), 3.26 (t, 2H), 3.28 (s, 3H), 3.62 (dt, 2H), 3.38 (t, 2H), 4.96 (tt, IH), 7.02 (d, IH), 7.20 (tt, IH), 7.31 (td, 2H), 7.40 (dd, 2H), 7.48 (dd, IH), 7.57 (d, IH), 7.65 (d, 2H), 7.85 (d, 2H), 7.89 (dd, IH), 7.96 (d, 2H), 8.53 (d, IH), 8.55 (t, IH). Example 362 N-((2'-methoxy-4'-(3-(4-methylpiperazin-l-yP-3-oxopropyl)-l,l'-biphenyl-4-vPcarbonyl)-3- nitro-4-((2-(pheny lthio) ethyl) -ιmino)benzenesulfonamide Example 362A methyl 2'-methoxy-4'-(3-(4-methylpiperazin-l-yP-3-oxopropyl)-l,r-biphenyl-4-carboxy late The desired product was prepared by substituting 1-methylpiperazine for morphohne in Example 122M. MS (ESI(-)) m/e 716 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.79 (t, IH), 8.63 (d, IH), 7.94 (dd, IH), 7.88 (d, 2H), 7.57 (d, 2H), 7.37 (m, 2H), 7.30-7.14 (m, 5H), 7.02 (d, IH), 6.92 (dd, IH), 3.76 (s, 3H), 3.67 (q, 2H), 3.44 (m, 4H), 3.28 (t, 2H), 2.85 (t, 2H), 2.80 (s, 3H), 2.72 (t, 2H), and the 8 remaining protons are buried uder a very broad water peak (3.75-3.40 ppm). Example 362B N-((2'-methoxy-4'-(3-(4-methylpiperazin- 1 -yl)-3 -oxopropyl)- 1 , 1 '-biphenyl-4-yl)carbonyl)-3- nitro-4-((2-(phenyltlno)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 362A and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. Example 363 N-(4-(l-methyl-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting methylamine for cyclopentylamine in Example 349. MS (ESI) m/e 586, 588 (M-H) " ', (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 3.28 (t, 2H), 3.60 (dt, 2H), 3.87 (s, 3H), 6.98 (d, IH), 7.19 (tt, IH), 7.32 (t, 2H), 7.40 (d, 2H), 7.47-7.68 (m, 5H), 7.88 (dd, IH), 7.95 (t, 2H), 8.21 (s, IH), 8.51 (t, IH), 8.52 (d, IH). Example 364 ethyl 4-(4-((((3-ιιitro-4-((2- (phenylthio)ethypamino)phenyl)sulfonyl)amino)carbonyl)phenyl)piperazine-l-carboxylate The desired product was prepared by substituting benzyloxyacetyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 612 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.71 (t, IH), 8.57 (d, IH), 7.88 (dd, IH), 7.76 (d, 2H), 7.39-7.35 (m, 2H), 7.23-7.29 (m, 2H), 7.20-7.14 (m, 2H), 6.92 (d, 2H), 4.06 (q, 2H), 3.65 (q, 2H), 3.50-3.46 (m, 4H), 3.32-3.23 (m, 6H), 1.20 (t, 3H). Example 365 N-(4-(3-methyl-2-vinyl- 1 -benzothien-5-vPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 365A 4-(3 -methy 1-2- vinyl- 1 -benzothien-5-yl)benzoic acid The desired product was prepared by substituting Example 35 IB for Example 1 A in Example IB. MS (ESIQ) m/e 293 (M-H) " . Example 365B N-(4-(3-methyl-2-vinyl-l-benzothien-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 365A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m e 628 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.49 (s, 3H), 3.29 (t, 2H), 3.69 (dt, 2H), 5.39 (d, IH), 5.61 (d, IH), 7.19 (m, 2H), 7.28 (dd, 2H), 7.38 (d, 2H), 7.74(dd, IH), 7.90-8.08 (m, 8H), 8.53 (d, IH), 8.80 (dd, IH). Example 366 4-(4-((((3-nitro-4-((2-(phenylthio)ethyPamino)phenyPsulfonyl)amino)carbonyl)phenvP-N- (2-phenylethyPpiperazine- 1 -carboxamide A solution of Example 173 A (54.1 mg, 0.1 mmol) in NMP (2 mL) at room temperature was treated with phenethylisocyanate (0.2 mmol), stirred for 18 hours, dUuted with water, and centrifuged. The sohd was purified by flash column chromatography on sUica gel with 0-5% methanol/dichloromethane to provide the desired product. MS (ESI(-)) m/e 687 (M-H) " ; l H NMR (300 MHz, DMSO-d 6 ) δ 8.75 (t, IH), 8.58 (d, IH), 7.90 (dd, IH), 7.75 (d, 2H), 7.39-7.34 (m, 2H), 7.31-7.14 (m, 9H), 6.94 (d, 2H), 6.71 (t, IH), 3.66 (q, 2H), 3.42-3.39 (m, 4H), 3.30-3.21 (m, 8H), 2.72 (dd, 2H). Example 367 N-(4-(2-(3-morphoHn-4-yl-3-oxopropyl)-l,3-benzothiazol-5-yl)benzoyP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting moiphohne for piperidine in Example 320. MS (ESI) m/e 730, 732 (M-H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 2.95 (t, 3H), 3.27 (t, 2H), 3.36 (t, 2H), 3.42-3.65 (m, 10H), 6.99 (d, IH), 7.22 (tt, IH), 7.32 (td, 2H), 7.40 (dd, 2H), 7.72 (d, 2H), 7.74 (dd, IH), 7.88 (dd, IH), 7.98 (d, 2H), 8.10 (d, IH), 8.18 (d, IH), 8.52 (d, IH), 8.52 (t, IH). Example 368 3 -mtro-N-(4-( 1 -pentyl- 1 H-pyrazol-4-yl)benzoyl)-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 322B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 592 (M-H) " ; ai MR (300 MHz, DMSO-d 6 ) δ 0.85 (t, 3H), 1.25 (m, 4H), 1.80 (tt, 2H), 3.27 (t, 2H), 3.61 (dt, 2H), 4.09 (t, 2H), 7.00 (d, IH), 7.20 (t, IH), 7.30 (t, 2H), 7.40 (d, 2H), 7.51 (d, 2H), 7.87 (m, 4H), 8.21 (s, IH), 8.51 (d, IH), 8.54 (t, IH). Example 369 N-(4-(l-benzyl-lH-pyrrol-3-yPbenzovP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 369A l-benzyl-2,5-dihydro-lH-pyrrol-3-yl trifluoroacetate The desired product was prepared by substituting l-benzyl-3-pyrroHdinone for 4-tert- butylcyclohexanone in Example 5A. Example 369B methyl 4-(l-benzyl-lH-pyrrol-3-yl)benzoate The desired product was prepared by substituting Example 369A for Example 5 A in Example 5B. MS (DCI (+)) m/e 292 (M+H) + . Example 369C N-(4-( 1 -benzyl- 1 H-pyrrol-3-vPbenzovP-3 -nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 369B for Example 23 OB in Example 230C. MS (ESI(-)) m/e 611 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.78 (br t, IH), 8.62 (d, IH), 7.92 (dd, IH), 7.80 (d, 2H), 7.60 (d, 2H), 7.50 (t, IH), 7.40-7.15 (m, HH), 6.92 (t, IH), 6.55 (t, IH), 5.10 (s, 2H), 3.65 (m, 2H), 3.35 (m, 2H). Example 370 (3R)-N-(tert-butvP-3-((4-((((4'-fluoro-l,l'-biphenyl-4-vPcarbonyl)amino)sulfonvP-2- nitrophenyPamino)-4-(phenylthio)butanamide Example 370A (3R)-3-((4-(aminosulfonyP-2-nitrophenyl)amino)-N-(tert-butyl)-4-(phenylthio)butanamide The desired product was prepared by substituting tert-butylamine for dimethylamine in Example 122F. Example 370B (3R)-N-(tert-butvP-3-((4-((((4'-fluoiO- 1 , 1 '-biphenyl-4-yl)carbonyl)amino)sulfonyl)-2- nitrophenyPamino)-4-(phenylthio)butanamide The desired product was prepared by substituting Example 370A for Example IC in Example ID. MS (ESI(-)) m/e 663 (M-H) " ; 1H NMR (500 MHz, methanol-ά^) δ 8.73 (d, IH), 8.09 (d, IH), 7.93 (dd, IH), 7.67 (m, 4H), 7.32 (m, 2H), 7.20-7.10 (m, 4H), 6.97 (d, IH), 4.40 (m, IH), 3.36 (dd, IH), 3.22 (dd, IH), 2.62 (m, 2H), 1.22 (s, 9H). • Example 371 4-((2-(((tert-butylamino)carbonyPamino)-l-((phenyltMo)methyPethyl)amino)-N-((4'-fluoro- 1.1 '-biphenyl-4-vPcarbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting tert-butyl isocyanate for acetyl chloride in Example 310. MS (ESI(-)) m/e 678 (M-H) " ; 1H NMR (400 MHz, methanol-d 4 ) δ 8.76 (d, IH), 7.93 (m, 3H), 7.72 (d, IH), 7.69 (m, 2H), 7.31 (m, 2H), 7.22-7.10 (m, 5H), 7.04 (d, IH), 4.16 (m, IH), 3.38 (m, 2H), 3.17 (dd, IH), 1.21 (s, 9H), and the remaining proton is buried under solvent peaks. Example 372 3-nitro-4-rr2- henylthio)ethvPamino)-N-(4-((lS,4R)-l,7,7-trimethylbicvclo(2.2.1)hept-2- yPbenzoyPbenzenesulfonamide Example 372A πR,4R)-l,7,7-trimethylbicvclo(2.2.1)hept-2-en-2-yl trifluoroacetate The desired product was prepared by substituting camphor for 4-tert- butylcyclohexanone in Example 5A. Example 372B methyl 4-(πR,4R)-l,7,7-trimethylbicvclo(2.2.1)hept-2-en-2-yl)benzoate The desired product was prepared by substituting Example 372A for Example 5A in Example 5B. MS (DCI (+)) m/e 243 (M+H) + . Example 372C methyl 4-((lS,4R)-l,7,7-trimethylbicvclo(2.2.1 hept-2-yPbenzoate A mixture of Example 372B (100 mg) and 10% Pd/C (20 mg) in ethyl acetate (5 mL) and ethanol (5 mL) at room temperature was stirred under H 2 for 18 hours, filtered, and concentrated to provide the desired product. MS (DCI(+)) m/e 245 (M+H) . Example 372D 3-mtro-4-f.2-(phenyltMo^ yPbenzoyPbenzenesulfonamide The desired product was prepared by substituting Example 372C for Example 230B in Example 230C. MS (ESI(-)) m/e 592 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.40-7.15 (m, 8H), 3.70 (m, 4H), 3.00(m, IH), 2.30 (m, IH), 1.95-1.10 (m, 6H), 1.00-0.70 (6s, 9H). Example 373 isopropyl 4-(4-((((3-nitro-4-((2- (phenyltMo)ethyl)-imino)phenyl)sulfonyl)amino)carbonyl)phenyPpiperazine-l-carboxylate The desired product was prepared by substituting isopropyl chloroformate for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 626 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.74 (t, IH), 8.58 (d, IH), 7.90 (dd, IH), 7.76 (d, 2H), 7.39-7.35 (m, 2H), 7.29-7.23 (m, 2H), 7.20-7.14 (m, 2H), 6.93 (d, 2H), 4.79 (hept, 2H), 4.06 (q, 2H), 3.66 (q, 2H), 3.50-3.44 (m, 4H), 3.32-3.23 (m, 6H), 1.20 (d, 6H). Example 374 N-(4-(2-cvanoquinoHn-8-yl)benzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 374A 2-cyanoquinohn-8-yl trifluoroacetate The desired product was prepared by substituting 2-cyano-8-hydroxyquinoline for vanillin in Example 122H. Example 374B N-(4-(2-cyanoquinoHn-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 374A for Example 389A in Example 389B. MS (ESI(-)) m/e 626 (M-H) " ; 1H NMR (400 MHz, methanol-d 4 ) 6 8.81 (d, IH), 8.52 (d, IH), 8.18 (d, IH), 8.05 (m, 2H), 7.97-7.87 (m, 6H), 7.79 (m, IH), 7.38 (m, 2H), 7.22 (tt, 2H), 7.17 (tt, IH), 7.07 (d, IH), 3.70 (q, 2H), 3.28 (t, 2H). Example 375 3-nitro-4-((2-(phenylthio)ethvPamino)-N-(4-(l-(pyridin-4-ylmethyP-1.2.3.6- tetrahydι-opyridin-4-yl)benzoyPbenzenesulfonamide The desired product was prepared by substituting 4-pyridinecarboxaldehyde for 3- pyridinecarboxaldehyde in Example 340B. MS (ESI(-)) m/e 628 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.78 (br t, IH), 8.70 (d, IH), 8.70 (dd, IH), 8.60 (d, IH), 8.05 (m, IH), 7.95 (d, 2H), 7.62 (d, 2H), 7.60 (dd, IH), 7.40-7.15 (m, 6H), 6.35 (m, IH), 4.52 (d, 2H), 3.92 (m, 4H), 3.45 (t, 4H), 2.82 (m, 2H). Example 376 3-nitro-4-^2-(phenylthio)ethvPamino)-N-(4-(l-(pyridin-2-ylmethyl)-l,2,3,6- tetrahydropyridin-4-yPbenzoyPbenzenesulfonamide The desired product was prepared by substituting 2-pyridinecarboxaldehyde for 3- pyridinecarboxaldehyde in Example 340B. MS (ESI(-)) m/e 628 (M-H) " ; H NMR (300 MHz, DMSO-dg) δ 8.78 (br t, IH), 8.70 (dd, IH), 8.62 (d, IH), 7.95 (dd ,1H), 7.92 (t, IH), 7.90 (d, 2H), 7.62 (d, 2H), 7.58 (d, IH), 7.50 (m, IH), 7.40-7.15 (m, 6H), 6.35 (m, IH), 4.52 (d, 2H), 3.92 (m, 2H), 3.65 (m, 2H), 3.55-3.35 (m4H), 2.82 (m, 2H). Example 377 ethyl 4-(5-(4-((r(3-nitro-4-((2- (phenyltMo)ethyPamino)phenyPsulfonyl)amino)carbonyl)phenyl)-l,3-benzothiazol-2- yPbutanoate The desired product was prepared by substituting ethyl 3-bromopropionate for aUyl bromide in Example 213. MS (ESI) m/e 703, 705 (M-H) " , (M+H) + ; X H NMR (300 MHz, DMSO-de) δ 1.19 (t, 3H), 2.08 (tt, 2H), 2.47 (t, 2H), 3.17 (t, 2H), 3.27 (t, 2H), 3.64 (dt, 2H), 4.07 (q, 2H), 7.09 (d, IH), 7.18 (tt, IH), 7.29 (td, 2H), 7.39 (d, 2H), 7.76 (d, IH), 7.80 (d, 2H), 7.93 (dd, IH), 7.98 (d, 2H), 8.18 (d, IH), 8.27 (d, IH), 8.57 (d, IH), 8.64 (t, IH). Example 378 N~2~-(tert-butoxycarbonyl)-N~l~-(l-flSf-(tert-butoxycarbonyPleucyP-4-(4-((((3-nitro-4-((2- (phenyltMo)ethyPamino)phenyPsulfonyPamino)carbonyl)phenyP-l,2,3,6-tettahydropyridin- 2-yP-N~l~-(;i-(K-(tert-butoxycarbonvPleucvP-4-(4-(r((3-nitro-4-((2- (phenylthio)ethyl)amino)phenyPsulfonypamino)carbonvPphenyl)-l,2,5,6-tettahv«-fropyridin- 2-ypleucinamide A mixture of Example 340A (150 mg, 0.25 mmol), BOC-leucine (70 mg, 0.3 mmol), EDCI (77 mg, 0.40 mmol), HOBT (55 mg, 0.40 mmol), and dusopropylethylamine (0.2 mL) in THF (0.5 mL) at room temperature was stirred for 16 hours, diluted with ethyl acetate (50 mL), washed sequentially with IN HCl (5 mL), water (30 mL) and brine (30 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5% methanol/dichloromethane to provide the desired product. MS (ESI(-)) m/e 750 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.72 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.50 (br d, IH), 7.55 (d, 2H), 7.40-7.15 (m, 6H), 6.35 (m, 1H),4.50 (m, IH), 4.18 (d, 2H), 3.65 (m, 4H), 3.40-3.25 (m, 4H), 1.65 (m, IH), 1.35 (s, 9H), 0.95 (d, 6H). Example 379 3-methyl-5->;4-((((3-nitro-4-rr2- (phenyltMo)ethyP-ιmino)phenyPsulfonypamino)carbonyl)phenyl)-l-benzothiophene-2- carboxamide A solution of Example 401D (100 mg, 0.16 mmol) in tert-butyl alcohol (5 mL) and water (0.5 mL) at room temperature was treated with KOH (500 mg, 8.90 mmol) and 18- crown-6 (400 mg, 1.51 mmol), heated to 100 °C for 90 minutes, treated with IM HCl (20 mL), and extracted with 10% methanol/ethyl acetate (3 x 50 mL). The combined extracts were washed with brine (10 mL), dried (Na 2 SO 4 ), fUtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 5-15% methanol/ethyl acetate to provide the desired product. MS (ESI) m/e 645, 647 (M-H) " , (M+H) + ; ! H NMR (300 MHz, DMSO-d 6 ) δ 1.90 (s, 3H), 3.27 (t, 2H), 3.62 (dt, 2H), 6.98 (d, IH), 7.20 (tt, IH), 7.31 (td, 2H), 7.40 (dd, IH), 7.68 (s, 2H), 7.74 (d, 2H), 7.80 (dd, IH), 7.90 (dd, IH), 7.99 (d, 2H), 8.04 (d, IH), 8.14 (d, IH), 8.50 (t, IH), 8.52 (d, IH). Example 380 N-(4-((((4'-fluoro-l , 1 '-biphenyl-4-yl)carbonyl)amino)sulfonyP-2-nitrophenyl)adamantane- 1 - carboxamide Example 380A 4-amino-N-((4'- fluoro- 1 , 1 '-biphenyl-4-yP carbonyl) -3 -nitrobenzenesulfonamide A solution of Example ID (1.0 g) in methanol (10 mL) and concentrated aqueous ammonia (3 mL) was heated in a sealed pressure tube to 60 °C for 16 hours, cooled to 0 °C, dUuted with ethyl acetate (100 mL), washed with water (30 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product. Example 380B N-(4-((((4'-fluoro-l,r-biphenyl-4-ypcarbonvPamino)sulfonyP-2-nitrophenypadamantane-l- carboxamide A solution of Example 380A (101 mg, 0.25 mmol) in THF (3 mL) was treated with 60% sodium hydride in oU (40 mg, 1.0 mmol), stirred for 30 minutes, treated with 1- adamantanecarbonyl chloride (60 mg, 0.30 mmol), stirred for 30 minutes, adjusted to pH <7 with 4M HCl in dioxane (0.5 mL), fUtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 30-100% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 576 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 10.23 (s, IH), 8.52 (d, IH), 8.23 (dd, IH), 8.19 (d, IH), 7.95 (d, 2 H, 7.75 (m, 4H), 7.31 (tt, 2H), 2.05 (3s, 3H), 1.90 (m, 6H), 1.70 (m, 6H). Example 381 N-( 4-(2-hexyl- 1 ,3-benzothiazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting 1-iodopentane for aUyl bromide in Example 213. MS (ESI) m/e 673, 675 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 0.87 (t, 3H), 1.17-1.44 (m, 6H), 1.82 (tt, 2H), 3.12 (t, 2H), 3.27 (t, 2H), 3.62 (dt, 2H), 7.02 (d, IH), 7.19 (tt, IH), 7.31 (t, 2H), 7.39 (d, 2H), 7.73 (d, 2H), 7.74 (d, IH), 7.89 (dd, IH), 7.98 (d, 2H), 8.12 (d, IH), 8.22 (d, IH), 8.53 (d, IH), 8.55 (t, IH). Example 382 N-((3.4'-difluoro-l,r-biphenyl-4-vPcarbonvP-3-nitro-4-(;(2- (phenylthio)ethyl)amino)benzenesulfonamide Example 382A methyl 4-chloro-2-fluorobenzoate The desired product was prepared by substituting 3-chloro-2-fluorobenzoic acid for 4- bromo-3-fluorobenzoic acid in Example 311A. Example 382B methyl 3 ,4'-difluoro- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 382A and 4- fluorophenylboronic acid for 5-chloro-2-methyl-l,3-benzoxazole and 4- (methoxycarbonyl)phenylboronic acid in Example 54A. Example 382C N-((3,4 , -difluoro-l,r-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (pheny lthio) ethyl) ammo)benzenesulfonamide The desired product was prepared by substituting Example 382B and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 568 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.64 (t, IH), 8.54 (d, IH), 7.88 (dd, IH), 7.78 (m, 2H), 7.70 (t, IH), 7.49 (m, 2H), 7.39 (m, 2H), 7.30 (m, 4H)-7.20 (tt, IH), 7.10 (d, IH), 3.66 (q, 2H), 3.20 (t, 2H). Example 383 N-((2'-methoxy-4'-(2-morphoHn-4-yl-2-oxoethvP-l.l'-biphenyl-4-vPcarbonylV3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 383 A methyl 2'-methoxy-4'-(2-morphoHn-4-yl-2-oxoethyP-l , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting morphoHne for 1-methylpiperazine in Example 328B. Example 383B N-((2'-methoxy-4'-(2-morphoHn-4-yl-2-oxoethyP- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 383 A and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 689 (M-H) " ; a NMR (500 MHz, DMSO-de) δ 8.77 (t, IH), 8.62 (d, IH), 7.93 (dd, IH), 7.88 (d, 2H), 7.57 (d, 2H), 7.37 (m, 2H), 7.26 (m, 3H), 7.18 (m, 2H), 6.99 (d, IH), 6.89 (dd, IH), 3.76 (s, 2H), 3.75 (s, 3H), 3.67 (q, 2H), 3.56-3.52 (m, 6H), 3.47 (m, 2H), 3.26 (d, 2H). Example 384 4-((4-azido- 1 -((phenylthio)methyl)butyl)amino)-N-((4 '-fluoro- 1 , 1 '-bipheny 1-4-yl) carbonyp- 3 -nitrobenzenesulfonamide Example 384A. methyl (2E)-4-((tert-butoxycarbonyl)amino)-5-(phenylthio)pent-2-enoate A solution of Example 175A (798 mg, 2.56 mmol) in toluene at -78 °C was treated with IM DIBAL-H in toluene (3.1 mL), stirred for 2 hours, poured into a mixture of IM HCl (5 mL) and ice (~15 g), and extracted with ethyl acetate (100 mL). The extract was washed with 0.1M HCl (20 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was treated with methyl (triphenylphospharanylidene)acetate (1.35 g, 4.0 mmol). and THF (10 mL), stirred at room temperature for 16 hours, dUuted with hexanes (20 mL), and fUtered through sUica gel (20 g). The sUica gel pad was rinsed with 1 : 1 ethyl acetate/hexanes and the combined organic phases were concentrated. The concentrate was purified by flash column chromatography on sUica gel with 10-20% ethyl acetate/hexanes to provide the desired product. Example 384B methyl 4-((tert-butoxycarbonvPamino)-5-(phenylthio)pentanoate A mixture of Example 384A (650 mg, 1.92 mmol) and 10% Pd/C (2.3 g, 2.2 mmol) in ethyl acetate (15 mLO and methanol (5 mL) was stirred at room temperature under a hydrogen balloon for 6 hours and filtered through diatomaceous earth (Cehte ). The pad was rinsed with hot ethyl acetate, and the combined organic phases were concentrated to provide the desired product. Example 384C tert-butyl 4-hydroxy- 1 -((phenylthio)methyPbutylcarbamate A solution of Example 384B (538 mg, 1.6 mmol) in THF (4 mL) at -50 °C was treated with IM lithium triethylborohydride in THF (4 mL), stirred for 1 hour, poured into ice (-15 g), and extracted with ethyl acetate (100 mL). The extract was washed with water (20 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product of sufficient purity for subsequent use. Example 384D tert-butyl 4-azido- 1 -((phenylthio)methypbutylcarbamate The desired product was prepared by substituting Example 384C for Example 434B in Example 434C. Example 384E 4-((4-azido-l-((phenylthio)methyl)butyPamino)-N-((4'-fluoro-l,r-biphenyl-4-yl)carbonyP- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 384D for Example 175B in Example 175D. MS (ESI(-)) m e 607 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.57 (d, IH), 8.33 (d, IH), 7.98 (d, 2H), 7.87 (dd, IH), 7.70 (m, 4H), 7.32 (m, 2H), 7.24 (m, 2H), 7.13 (m, 4H), 4.15 (m, IH), 3.38 (m, 2H), 2.51 (m, 2H), 1.81 m, 2H), 1.60 (m, 2H). Example 385 N-butyl-3-(5-(4-((((3-nitro-4-((2- (phenyltMo)ethypamino)phenypsulfonvPamino)carbonyPphenyl)-l,3-benzothiazol-2- yppropanamide The desired product was prepared by substituting Example 330A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 716, 718 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 0.83 (t, 3H), 1.24 (m, 2H), 1.35 (m, 2H), 2.66 (t, 2H), 3.05 (tt, 2H), 3.28 (t, 2H), 3.30 (t, 2H), 3.61 (dt, 2H), 7.01 (d, IH), 7.20 (tt, IH), 7.31 (td, 2H), 7.40 (dd, 2H), 7.72 (d, 2H), 7.74 (dd, IH), 7.88 (dd, IH), 7.92 (t, IH), 7.98 (d, 2H), 8.11 (d, IH), 8.12 (dd, IH), 8.52 (d, IH), 8.54 (t, IH). Example 386 3 -nitro-4-((2-(pheny lthio) ethyl) amino)-N-(4-(4-(2-propylpentanoyPpiperazin- 1 - yPbenzoyPbenzenesulfonamide The desired product was prepared by substituting dipropylacetyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 666 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.77 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.76 (d, 2H), 7.39-7.35 (m, 2H), 7.29-7.14 (m, 4H), 6.95 (d, 2H), 4.79 (hept, 2H), 3.70-3.60 (m, 6H), 3.32-3.23 (m, 6H), 2.82- 2.73 (m, IH), 1.56-1.43 (m, 2H), 1.34-1.16 (m, 4H), 0.83 (t, 6H). Example 387 N-(4-(l-butyl-2-(2-methoxyethyl)-lH-benzimidazol-5-yl)benzoyP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 387A 5-bromo- 1 -butyl-2-(2-methoxyethyP- 1 H-benzimidazole The desired product was prepared by substituting Example 166B and 3- methoxypropionic acid for Example 343A and valeric acid, respectively, in Example 343B. Example 387B N-(4-(l-butyl-2-(2-methoxyethyP-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 387A and Example 214D for 6-bromoindole and 4-(dihydroxyboryl)benzoic acid, respectively, in Example 4A. MS (ESI) m/e 686, 688 (M-H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 0.92 (t, 3H), 1.35 (qt, 2H), 1.72 (tt, 2H), 2.12 (t, 2H), 3.26 (t, 2H), 3.28 (s, 3H), 3.61 (dt, 2H), 3.84 (t, 2H), 4.23 (t, 2H), 6.99 (d, IH), 7.21 (tt, IH), 7.32 (td, 2H), 7.40 (d, 2H), 7.46-7.68 (m, 4H), 7.89 (dd, IH), 7.93-7.98 (m, 3H), 8.52 (d, IH), 8.53 (t, IH). Example 388 N-(4-((lS,4R)-bicvclo(2.2.1)hept-2-en-2-vPbenzovP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 388A (1 S,4R)-bicyclo.2.2. l)hept-2-en-2-yl trifluoroacetate The desired product was prepared by substituting norcamphor for 4-tert- butylcyclohexanone in Example 5 A. Example 388B methyl 4-((lS.4R)-bicvclo(2.2. l)hept-2-en-2-vPbenzoate The desired product was prepared by substituting Example 388A for Example 5A in Example 5B. MS (DCI(+)) m/e 229 (M+H) + . Example 388C N-f4-(πS,4R)-bicvclo(2.2.1)hept-2-en-2-yl)benzovP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 388B for Example 23 OB in Example 230C. MS (ESI(-)) m/e 548 (M-H) " ; ! H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.50 (d, 2H), 7.40-7.15 (m, 6H), 6.60 (d, IH), 3.70 (m, 2H), 3.40 (m, IH), 3.00 (m, IH), 1.75 (m, 2H), 1.45 (m, 2H), 1.25 (m, 2H), 1.05 (m, 2H). Example 389 N-(4-(5-fluoroquinoHn-8-yl)benzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 389A 5-fluoroquinolin-8-yl trifluoroacetate The desired product was prepared by substituting 5-fluoro-8-hydroxyquinoHne for vanillin in Example 122H. Example 389B N-(4-(5-fluoroquinolin-8-vPbenzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide A mixture of Example 108A (176 mg, 0.30 mmol), Example 389A (180 mg, 0.60 mmol), Pd 2 dba 3 (27 mg, .0.03 mmol), triphenylarsine (37 mg, 0.12 mmol) and lM Na 2 CO 3 (3 mL) in 1,4-dioxane (6 mL) was heated to 90 °C for 16 hours, cooled to room temperature, dUuted with ethyl acetate (200 mL), washed with water (100 mL) and brine (50 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 1 : 1 ethyl acetate/dichloromethane to provide the desired product. MS (ESI(-)) m/e 601 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.99 (dd, IH), 8.74 (br t, IH), 8.62 (d, IH), 8.57 (dd, IH), 7.95 (m, 4H), 7.82 (dd, IH), 7.70 (m, 3H), 7.55 (dd, IH), 7.48 (d, 2H), 7.28 (t, 2H), 7.19 (m, 2H), 3.67 (q, 2H), 3.28 (t, 2H). Example 390 N~2~-(4-((( 4'-fluoro-l,r-biphenyl-4-yl)carbonyPamino)sulfonyl)-2-nitrophenyP-S- phenylcysteinamide Example 390A 2 N -tert-butoxycarbonyl-S-phenylcysteinamide The desired product was prepared by substituting 0.5M ammonia in dioxane for morphohne in Example 180A. Example 390B N~2 — (4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yPcarbonyP amino)sulfonyP-2-nitrophenyl)-S- phenylcysteinamide The desired product was prepared by substituting Example 390A for Example 175B in Example 175D. MS (ESI(-)) m/e 593 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.49 (d, IH), 7.96 (d, 2H), 7.89 (dd, IH), 7.75 (m, 3H), 7.60 (d, 2H), 7.45 (IH), 7.32-7.13 (m, 7H), 4.52 (m, IH), 3.60 (m, IH), 2.45 (m, IH). Example 391 N-(4-(2-aminoquinolin-8-yPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 355A for Example 389A in Example 389B. MS (ESI(-)) m/e 598 (M-H) " ; H NMR (400 MHz, DMSO-d 6 ) δ 8.67 (t, IH), 8.58 (d, IH), 7.95 (m, 5H), 7.80-7.45 (m, 6H), 7.39 (m, 2H), 7.30 (t, 2H), 7.20 (tt, IH), 3.65 (q, 2H), 3.28 (t, 2H). Example 392 3-nitro-4-((2-(phenylthio)ethvPamino)-N-(4-(l-(pyridin-3-ylcarbonyl)-l,2,3,6- tetrahydropyridin-4-yPbenzovPbenzenesulfonamide The desired product was prepared by substituting nicotinoyl chloride for 4- morpholinecarbonyl chloride in Example 317. MS (ESI(-)) m/e 642 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.80 (br t, IH), 8.70 (d, 2H), 8.62 (d, IH), 7.92(m,2H), 7.89 (d, 2H), 7.58 (d, 2H), 7.55 (m, IH), 7.40-7.15 (m, 6H), 6.45 and 6.25 (2m, IH), 4.32 and 4.12 (2d, 2H), 3.92 (m, 2H), 3.65 (m, 2H), 3.25 (t,2H), 2.62 (m, 2H). Example 393 4-((3-tert-butoxy-2-(phenylthio)propyl)amino)-N-((4'-fluoro-l , 1 '-biphenyl-4-vPcarbonyl)-3- nitrobenzenesulfonamide and 4-((2-tert-butoxy- 1 -((phenylthio)methyl) ethyl) amino)-N-((4'- fluoro-l.r -biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide Example 393A 3-tert-butoχy-2-(phenylthio)propan-l-ol and l-tert-butoxy-3-(phenylthio)propan-2-ol The desired products were prepared by substituting tert-butyl glycidyl ether for cyclohexene oxide in Example 7A. Example 393B ((2-azido-l-(tert-butoxymethyl)ethyl)thio)benzene and ((2-azido-3-tert- butoxypropyl)thio)benzene The desired product was prepared by substituting Example 393 A for Example 7 A in Example 7B. Example 393C 4-((3-tert-butoxy-2-(phenylthio)propyl)amino)-3-nitrobenzenesulfonamide and 4-((2-tert- butoxy-l-((phenylthio)methyl)ethyl)amino)-3-nitrobenzenesulfonamide A mixture of Example 393B (877 mg, 3.03 mmol), triphenylphosphine (1.58 g, 6.0 mmol), and water (0.18 mL, 10 mmol) in THF (95 mL) at room temperature was stirred for 18 hours and concentrated. The concentrate was treated with Example 122C (801 mg, 3.64 mmol), N,N-diisopropylethylamine (1.0 mL), and 1,4-dioxane (5 mL), heated to 60 °C for 16 hours, diluted with ethyl acetate (100 mL), washed with water (45 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10-30% ethyl acetate/dichloromethane to provide the desired products as a 1.5: 1 mixture. MS (ESI(+)) m/e 440 (M+H) + Example 393D 4-((3-tert-butoxy-2-(phenylthio)propyPamino)-N-((4 '-fluoro- 1 , 1 '-biphenyl-4-vPcarbonyl)-3- nitrobenzenesulfonamide and 4-((2-tert-butoxy- 1 -((phenylthio)methyl)ethyl)amino)-N-((4'- fluoro- 1,1' -biphenyl-4-yl)cai-bonyP-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 393C for Example IC in Example ID. MS (ESI(-)) m/e 636 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ), 2: 1 mixture of isomers δ 8.84 (br t, 2/3H), 8.68 (br d, 1/3H), 8.62, 8.61 (2d, IH), 7.96 (2d, 2H), 7.92, 7.89 (2dd, IH), 7.78 (m, 4H), 7.45-7.10 (m, 8H), 4.14 (m, 2/3H), 3.80-3.50 (m, 4H), 1.12, 1.11 (2s, 9H). Example 394 N-(4-( 1 -(cyclohexylmethyp- 1 H-pyrazol-4-yl)benzoyl)-3 -nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 394A 1 -(cvclohexylmethyl)-4-iodo- 1 H-pyrazole The desired product was prepared by substituting (bromomethyl) cyclohexane for 1- bromooctane in Example 198 A. MS (ESI(+)) m/e 291 (M+H) + . Example 394B 4-( 1 -(cyclohexylmethyp- 1 H-pyrazol-4-yl)benzoic acid The desired product was prepared by substituting Example 394A for 6-bromoindole in Example 4. MS (ESI(-)) m/e 283 (M-H) " . Example 394C N-(4-(l-(cyclohexylmethyl)-lH-pyrazol-4-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 394B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 618 (M-H) " ; i NMR (300 MHz, DMSO-d 6 ) δ 0.95 (m, 2H), 1.18 (m, 4H), 1.52 (m, 2H), 1.63 (m, 2H), 1.81 (m, IH), 3.27 (t, 2H), 3.60 (dt, 2H), 3.92 (d, 2H), 6.99 (d, IH), 7.19 (t, IH), 7.30 (t, 2H), 7.40 (d, 2H), 7.51 (d, 2H), 7.87 (m, 4H), 8.18 (s, IH), 8.51 (d, IH), 8.54 (t, IH). Example 395 N-(4-(6-methoxypyridin-3-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting 5-bromo-2-methoxypyridine for 2, 8-bistrifluoromethyl-3-chloroquinoline in Example 319. MS (ESI) m/e 565, 563 (M+H) + , (M-H) " ; ! H NMR (500 MHz, DMSO-d 6 ) δ 8.78 (t,H), 8.63 (d, IH), 8.57 (d, IH), 8.09 (dd, IH), 7.97-7.93 (m, 3H), 7.81 (d, 2H), 7.37 (dt, 2H), 7.27 (td, 2H), 7.22 (d, IH), 7.17 (tt, IH), 6.93 (d, IH), 3.91 (s, 3H), 3.68 (q, 2H), 3.29 (t, 2H). Example 396 N-((2'-methoxy-4'-(2-morphoUn-4-ylethyP-l,r-biphenyl-4-ypcarbonyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 396A methyl 2'-methoxy-4'-(2-morphoHn-4-ylethyP- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 383A for Example 122F in Example 122G. Example 396B N-((2'-methoxy-4'-(2-morphoHn-4-ylethyP-l,r-biphenyl-4-yl)carbonyP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 396A and Example 77B for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 675 (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 10.3-10.1 (br s, IH), 8.78 (t, IH), 8.64 (d, IH), 7.94 (dd, IH), 7.90 (d, 2H), 7.57 (d, 2H), 7.37 (m, 2H), 7.36-7.18 (m, 5H), 7.06 (d, IH), 6.97 (dd, IH), 4.00 (m, 2H), 3.78 (s, 3H), 3.67 (q, 2H), 3.42 (m, 2H), 3.29 (t, 2H), 3.15 (m, 2H), 3.05 (m, 2H), remaining 2 protons are buried under water peak (3.8-3.4 ppm) . Example 397 N-((2'-methoxy-4'-(3-morphoHn-4-yl-3-oxopropyP- 1 , 1 '-biphenyl-4-yl)carbonyP-3-nitro-4- ((2-(phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 122M and Example 77B for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 703 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.79 (t, IH), 8.63 (d, IH), 7.94 (dd, IH), 7.88 (d, 2H), 7.57 (d, 2H), 7.37 (m, 2H), 7.30-7.14 (m, 5H), 7.02 (d, IH), 6.92 (dd, IH), 3.76 (s, 3H), 3.67 (q, 2H), 3.53 (m, 4H), 3.44 (m, 4H), 3.28 (d, 2H), 2.85 (t, 2H), 2.66 (t, 2H). Example 398 N-(2-hvdroxyethvP-3-methyl-5-(4-((((3-nitro-4-((2- (pheny lthio) ethyl) amino)phenyl) sulfonyl) amino) carbonypphenyp- 1 -benzothiophene-2- sulfonamide Example 398A 5-chloro-N-(2-hydroxyethyP-3-methyl-l-benzothiophene-2-sulfonamide The desired product was prepared by substituting 2-chlorosulfonyl-5-chloro-3- methylbenzothiophene and ethanolamine for dimethylcarbamic chloride and Example 183D, respectively, in Example 200. MS (ESI(-)) m/e 304 (M-H) " . Example 398B methyl 4-(2-(((2-hydroxyethyPamino)sulfonyP-3-methyl-l-benzothien-5-yPbenzoate The desired product was prepared by substituting Example 398A for 5-chloro-2- methyl-l,3-benzoxazole in Example 54A. MS (ESI(-)) m/e 404 (M-H) " . Example 398C methyl 4-(2-(((2-((tert-butyl(dimethyl)sUyPoxy)ethyl)amino)sulfonyl)-3-methyl-l- benzothien-5-yl)benzoate A solution of Example 398B (200 mg, 0.5 mmol), tert-butyldimethylsilyl chloride (85 mg, 0.55 mmol) and imidazole (36 mg, 0.6 mmol) in DMF (5 mL) at room temperature was stirred for 24 hours, dUuted with ether, filtered through a pad of sUica gel, and concentrated to provide the desired product. Example 398D 4-(2-(((2-((tert-butyl(dimethyPsilyPoxy)ethyl)ammo)sulfonyl)-3-methyl-l-benzothien-5- yPbenzoic acid The desired product was prepared by substituting Example 398C for Example 1A in Example IB. MS (ESI(-)) m/e 504 (M-H) " . Example 398E N-(2-hydroxyethvP-3-methyl-5-(4-(;((r3-nitro-4-((2- (phenylthio)ethyl)amino)phenyl)sulfonyl)amino)carbonyl)phenyl)-l-benzothiophene-2- sulfonamide The desired product was prepared by substituting Example 398D and Example 77B for Example IB and Example IC, respectively, in Example ID. The product was treated with TFA (5 mL), stirred for 2 hours, concentrated, dissolved in toluene, and concentrated again to provide the desired product. MS (ESI(-)) m/e 725 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 2.70 (s, 3H), 2.95 (dt, 2H), 3.28 (t, 2H), 3.38 (dt, 2H), 3.66 (dt, 2H), 4.22 (m, IH), 4.70 (m, IH), 7.19 (d, IH), 7.24-7.37 (m, 4H), 7.80 (m, 4H), 7.92 (dd, IH), 7.96 (d, 2H), 8.61 (d, IH), 8.78 (t, IH). Example 399 N-(l , 1 '-biphenyl-4-ylcarbonvP-3-nitro-4-((2-(phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting 4-biphenylcarboxylic acid and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 532 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (t, IH), 8.62 (d, IH), 7.97 (d, 2H), 7.94 (dd, IH), 7.79 (m, 2H), 7.73 (d, 2H), 7.49 (t, 2H), 7.42 (t, IH), 7.38 (m, 2H), 7.27 (m, 2H), 7.18 (m, 2H), 3.66 (q, 2H), 3.29 (t, 2H). Example 400 3-nitro-N-(4-r5-nitropyridin-2-yl)benzoyl)-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting 2-chloro-5-nitropyridine for 2,8- bistrifluoromethyl-3-chloroquinoHne in Example 319. MS (ESI) m/e 580 578 (M+H) + , (M- H) " ; 1H NMR (500MHz, DMSO-d 6 ) δ 9.47 (d, IH), 8.78 (t, IH), 8.69 (dd, IH), 8.64 (d, IH), 8.36 (d, IH), 8.31 (d, 2H), 8.05 (d, 2H), 7.95 (dd, IH), 7.37 (dt, 2H), 7.27 (td, 2H), 7.22 (d, IH), 7.17 (tt, IH), 3.68 (q, 2H), 3.29 (t, 2H). Example 401 N-(4-(2-cyano-3-methyl-l-benzothien-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethypamino)benzenesulfonamide Example 401 A 5-chloro-3 -methyl- 1 -benzothiophene-2-carbonitrUe A mixture of 2-bromo-5-chloro-3-methylbenzo(b)thiophene (1.00 g, 3.82 mmol), zinc cyanide (247 mg, 2.10 mmol), and Pd(PPh 3 ) 4 (440 mg, 0.38 mmol) in DMF (15 mL) was heated to 80 °C for 16 hours, added to water (50 mL), and extracted with 30% ethyl acetate/hexanes (3 x 100 mL). The combined extracts were washed with brine (20 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10% ethyl acetate/hexanes to provide the desired product. Example 40 IB methyl 4-(2-cvano-3 -methyl- 1 -benzothien-5-yl)benzoate A mixture of Example 401A (557 mg, 2.68 mmol), (4-methoxycarbonylphenyl)- boronic acid (675 mg, 3.75 mmol), Pd(OAc) 2 (36 mg, 0.16 mmol), 2-(di-tert- butylphosphino)biphenyl (63 mg, 0.21 mmol), and KF (467 mg, 8.04 mmol) in THF (10 mL) was heated to 60 °C for 16 hours and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 10% ethyl acetate/hexanes to provide the desired product. Example 40 IC 4-(2-cyano-3 -methyl- 1 -benzothien-5-yl)benzoic acid The desired product was prepared by substituting Example 401B for Example 1 A in Example IB. Example 40 ID N-(4-(2-cyano-3-methyl-l-benzothien-5-yl)benzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 40 IC and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 627, 629 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.70 (s, 3H), 3.27 (t, 2H), 3.62 (dt, 2H), 7.05 (d, IH), 7.19 (tt, IH), 7.29 (tt, 2H), 7.38 (dt, 2H), 7.82 (d, 2H), 7.91 (dd, IH), 7.97 (dd, IH), 8.01 (d, 2H), 8.20 (d, IH), 8.30 (d, IH), 8.55 (d, IH), 8.58 (t, IH). Example 402 N-((4'-fluoro-l,r-biphenyl-4-yl)carbonyl)-4-((3-methoxy-2-(phenylthio)propyl)amino)-3- nitrobenzenesulfonamide and N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyl)-4-((2-methoxy~ 1 - ((phenylthio)methyl) ethyl) amino)-3 -nitrobenzenesulfonamide Example 402A 3-methoxy-2-(phenylthio)propan-l-ol and l-methoxy-3-(phenylthio)propan-2-ol The desired product was prepared by substituting glycidyl methyl ether for cyclohexene oxide in Example 7A. Example 402B ((2-azido-l-(methoxymethyPethyl)thio)benzene compound and ((2-azido-3- methoxypropyl)thio)benzene The desired product was prepared by substituting Example 402 A for Example 7A in Example 7B. Example 402C 4-((3-methoxy-2-(phenylthio)propyl)amino)-3-nitrobenzenesulfonamide compound and 4 Z ((2-methoxy-l-((phenylthio)methyl)ethvPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 402 B for Example 393B in Example 393C. Example 402D N-((4'-fluoro-l,r-biphenyl-4-yPcarbonyl)-4-((3-methoxy-2-(phenylthio)propyPamino)-3- nitrobenzenesulfonamide and N-((4'-fluoro- 1 , 1 '-biphenyl~4-yl)carbonyP-4-((2-methoxy- 1 - ((phenylthio)methyl)ethyl) amino) -3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 402C for Example IC in Example ID. MS (ESI(-)) m/e 594 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ), mixture of two isomers, ratio (1.2:1) δ 8.86 (br t, ViR), 8.61, 8.59 (2d, IH), 8.53 (br d, 1/2H), 7.96 (2d, 2H), 7.89 (2dd, IH), 7.78 (m, 4H), 7.45-7.10 (m, 8H), 4.25 (m, 1/2H), 3.80-3.50 (m, 4.5H), 3.29, 3.27 (2s, 3H). Example 403 N-(4-(2-hydroxyquinolin-8-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethvPamino)benzenesulfonamide Example 403A 4-(2-hydroxyquinoHn-8-yl)benzoic acid The desired product was prepared by substituting Example 336B for Example 1 A in Example IB. Example 403B N-(4-(2-hydroxyquinolin-8-yPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyPammo)benzenesulfonamide The desired product was prepared by substituting Example 403A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 599 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.77 (t, IH), 8.53 (d, IH), 8.02 (d, 2H), 8.00 (d, IH), 7.95 (dd, IH), 7.72 (dd, IH), 7.60 (d, 2H), 7.40 (dd, IH), 7.37 (m, 2H), 7.38 (t, 2H), 7.22 (d, IH), 7.19 (tt, IH), 6.53 (d, IH), 3.67 (q, 2H), 3.28 (t, 2H). Example 404 N-((2'-methoxy-4'-(morphoHn-4-yhnethvP-l,r-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio ethvPamino benzenesulfonamide Example 404A methyl 2'-methoxy-4'-(morphoHn-4-ylmethyl)-l , 1 '-biphenyl-4-carboxylate A mixture of Example 1221 (135 mg, 0.50 mmol), morphohne (100 mg), IM sodium cyanoborohydride in THF (1 mL) in methanol (2 mL) and acetic acid (0.3 mL) was stirred for 18 hours, dUuted with ethyl acetate (100 mL), washed sequentially with 2M sodium carbonate (10 mL), water (20 mL), and brine (10 mL), dried (MgSO 4 ), fUtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 30-100% ethyl acetate/hexanes to provide the desired product. MS (DCI(+)) m/e 342 (M+H) + . Example 404B N-((2'-methoxy-4'-(morphoHn-4-ylmethyP-l .1 '-biphenyl-4-yPcarbonyP-3-mtro-4-(Y2- (ρhenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 404A and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m e 663 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.74 (t, IH), 8.61 (d, IH), 7.92 (m, 3H), 7.56 (d, 2H), 7.38 (m, 3H), 7.28 (m, 3H), 7.21-7.10 (m, 3H), 3.80 (s, 2H), 3.76 (s, 3H), 3.66 (q, 2H), 3.40- 3.20 (m, 4 H, buried in water peak). Example 405 tert-butyl 4-(4-((((3-aitro-4-((2- (phenylthio) ethyl) amino)phenyl) sulfonyl) amino) carbonypphenyppiperazine- 1 -carboxylate The desired product was prepared by substituting 4-(4- ((neopentyloxy)carbonyl)piperazin-l-yl)benzoic acid and Example 77B for Example IB and Example IC, respecitvely, in Example ID. MS (ESI(-)) m/e 640 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.77 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.76 (d, 2H), 7.36 (d, 2H), 7.14- 7.29 (m, 4H), 6.94 (d, 2H), 3.66 (q, 2H), 3.37-3.45 (m, 4H), 3.23-3.30 (m, 6H), 1.41 (s, 9H). Example 406 N~2~-(4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyl)amino)sulfonyl)-2-nitrophenyP- N~l~.N~l~-bis(4- -(4-((((4'-fluoro-l.l'-biphenyl-4-yPcarbonyPamino)sulfonvP-2- nitrophenyl)-S-phenylcysteinyl)morpholin-3-yl)-S-phenylcysteinamide The desired product was prepared by substituting Example 180B for Example 1 C in Example ID. MS (ESI(-)) m/e 663 (M-H) " ; H NMR (300 MHz, dmso-de) δ 8.95 (d, IH), 8.49 (d, IH), 7.97 (d, 2H), 7.91 (dd, IH), 7.72 (m, 4H), 7.60 (d, 2H), 7.27 (m, 4H), 7.15 (m, 4H), 5.27 (m, IH), 3.57 (m, 4H), 3.50 (m, 4H), 3.37 (dd, IH), 3.20 (m, IH). Example 407 N-(4-(4,4-dimethylcyclohexyl)benzoyl)-4-((2-mo holin-4-yl- 1 - ((phenyltMo)methyPethyP-ιmino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 77A and Example 245A for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 665 (M-H) " ; ! H NMR (400 MHz, methanol-di) δ 8.66 (d, IH), 7.90 (dd, IH), 7.84 (d, 2H), 7.28 (m, 4H), 7.07 (m, 3H), 6.91 (d, IH), 4.14 (m, IH), 3.30 (t, 4H), 3.40 (dd, IH), 3.21 (dd, IH), 2.72 (m, 2H), 2.51 (m, 5H), 1.64 (m, 4H), 1.49 (m, 2H), 1.35 (m, 2H), 0.98 (s, 3H), 0.94 (s, 3H). Example 408 4-((2-amino- 1 -((phenylthio)methyl)ethyl)amino)-N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl)carbonyP- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 434D for Example 384E in Example 125. MS (ESI(-)) m e 579 (M-H) " ; 1H NMR (300 MHz, dmso-d 6 ) δ 8.59 (d, IH), 8.33 (d, IH), 8.05 (m, 3H), 7.97 (d, 2H), 7.87 (dd, IH), 7.78 (m, 4H), 7.35-7.11 (m, 8H), 4.40 (m, IH), 3.25 (m, 2H), (remaining 2 protons are buried under water peak, 3.50-3.30 ppm). Example 409 benzyl 4-(4-((((3-nitro-4-((2- (phenyltMo)ethyPamino)phenyl)sulfonyl)amino)carbonyPphenyl)piperazine-l-carboxylate t The desired product was prepared by substituting benzyloxyacetyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 674 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.74 (t, IH), 8.58 (d, IH), 7.90 (dd, IH), 7.76 (d, 2H), 7.39-7.14 (m, HH), 6.93 (d, 2H), 5.10 (s, 2H), 3.65 (q, 2H), 3.51-3.57 (m, 4H), 3.32-3.23 (m, 6H). Example 410 3-nitro-4-((2-(phenylthio)ethyl)amino)-N-(4-(l-(pyridin-2-ylcarbonyl)-1.2.3,6- tetrahydropyridin-4-yl)benzoyl)benzenesulfonamide The desired product was prepared by substituting picolinoyl chloride for 4- morpholinecarbonyl chloride in Example 317. MS (ESI(-)) m/e 642 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.80 (br t, IH), 8.62 (d, IH), 7.95 (m, 2H), 7.85 (d, 2H), 7.62-7.48 (m, 4H), 7.40-7.15 (m, 76H), 6.45 and 6.25 (2m, IH), 4.32 and 4.12 (2d, 2H), 3.92 (t, 2H), 3.65 (m, 2H), 3.25 (t,2H), 2.62 (m, 2H). Example 411 N,N-diethyl-3-methyl-5-(4-((((3-nitro-4-((2- (phenylthio)ethyl)amino)phenyl)sulfonyl)amino)carbonyPphenyp-l-benzothiophene-2- sulfonamide Example 411 A 5-chloro-N,N-diethyl-3-methyl- 1 -benzothiophene-2-sulfonamide The desired product was prepared by substituting 2-chlorosulfonyl-5-chloro-3- methylbenzthiophene and dimethylamine for dimethylcarbamic chloride and Example 183D, respectively, in Example 200. MS (ESI(+)) m/e 318 (M+H) + . Example 41 IB methyl 4-(2-((diethylamino)sulfonyl)-3-methyl-l-benzothien-5-yPbenzoate The desired product was prepared by substituting Example 411 A for 5-chloro-2- methyl- 1 ,3 -benzoxazole in Example 54A. ' Example 41 IC 4-(2-((diethylamino)sulfonyl)-3-methyl-l-benzothien-5-yl)benzoic acid The desired product was prepared by substituting Example 41 IB for Example 1A in Example IB. MS (ESI(-)) m/e 402 (M-H) " . Example 41 ID N,N-diethyl-3-methyl-5-(4-(r((3-nitro-4-r(2- (phenylthio)ethypamino)phenyl)sulfonyl)amino)carbonyl)phenyl)-l-benzothiophene-2- sulfonamide The desired product was prepared by substituting Example 41 IC and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 737 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.10 (t, 6H), 2.72 (s, 3H), 3.28 (q, 4H), 3.36 (t, 2H), 3.62 (dt, 2H), 7.00 (d, IH), 7.20 (t, IH), 7.31 (t, 2H), 7.41 (d, 2H), 7.77 (d, 2H), 7.90 (d, 2H), 8.01 (d, 2H), 8.12 (d, IH), 8.22 (s, IH), 8.51 (t, IH), 8.53 (t, IH). Example 412 N-(4-(3-methyl-2-moι hoHn-4-yl-l-benzothien-5-yPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 412A 4-(5-cMoro-3-methyl-l-benzotMen-2-yl)morpholine A mixture of 2-bromo-5-chloro-3-methylbenzthiophene (523 mg, 2 mmol), morphohne (210 uL, 2.4 mmol), Pd 2 dba 3 (37 mg, 0.04 mmol), BINAP (62 mg, 0.1 mmol), and sodium tert-butoxide (270 mg, 2.8 mmol) in toluene (5 mL) was stirred at 80 °C for 18 hours. The reaction mixture was purified by flash column chromatography on silica gel with 20% ethyl acetate/hexanes to provide the desired product. MS (ESI(+)) m/e 268 (M+H) . Example 412B methyl 4-(3-methyl-2-morphoHn-4-yl- 1 -benzothien-5-yl)benzoate The desired product was prepared by substituting Example 412A for 5-chloro-2- methyl-l,3-benzoxazole in Example 54 A. Example 412C 4-(3-methyl-2-morphoUn-4-yl-l-benzothien-5-yPbenzoic acid The desired product was prepared by substituting Example 412B for Example 1 A in Example IB. MS (ESI(-)) m/e 352 (M-H) " . Example 412D N-(4-(3-methyl-2-moφhoHn-4-yl-l-benzothien-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was preparede by substituting Example 412C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 687 (M-H) " ; l H NMR (300 MHz, DMSO-d 6 ) δ 2.31 (s, 3H), 2.95 (m, 4H), 3.28 (t, 2H), 3.67 (dt, 2H), 3.79 (m, 4H), 7.19 (m, 2H), 7.28 (t, 2H), 7.38 (d, 2H), 7.48 (t, IH), 7.62 (d, IH), 7.85-8.00 (m, 6H), 8.62 (d, IH), 8.78 (t, IH). Example 413 N-(4-(2-methyl- 1.3-benzothiazol-5-vPbenzoyP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 17A and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 603, 605 (M-H) " , (M+H) + ; l H NMR (300 MHz, DMSO-d 6 ) δ 2.83 (s, 3H), 3.28 (t, 2H), 3.62 (dt, 2H), 7,02 (d, IH), 7.19 (tt, IH), 7.30 (td, 2H), 7.39 (dt, 2H), 7.73 (dd, IH), 7.74 (d, 2H), 7.89 (dd, IH), 7.98 (d, 2H), 8.10 (d, IH), 8.19 (d, IH), 8.53 (d, IH), 8.55 (t, IH). Example 414 N-(4-(3-methyl- 1 -pentyl- 1 H-pyrazol-4-yl)benzoyl)-3 -nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide and N-(4-(5-methyl- 1 -pentyl- 1 H-pyrazol-4- yPbenzoyl)-3-nitro-4-((2-(phenylthio)ethyl)amino)benzenesulfonamide Example 414A 4-bromo-5-methyl- 1 -pentyl- 1 H-pyrazole and 4-br omo-3 -methyl- 1 -pentyl- 1 H-pyrazole The desired product was prepared by substituting 1-iodopentane and 4-bromo-3- methylpyrazole for 1-bromooctane and 4-iodopyrazole, respectively, in Example 198A. MS (ESI(+)) m/e 231, 233 (M+H) + . Example 414B 4-(5-methyl- 1 -pentyl- 1 H-pyrazol-4-yl)benzoic acid and 4-(3 -methyl- 1 -pentyl- 1 H-pyrazol-4- vPbenzoic acid The desired product was prepared by substituting Example 414A for 6-bromoindole in Example 4A. MS (ESI) m/e 271 (M-H) " . Example 414C N-(4-f 3-methyl- 1 -pentyl- 1 H-pyrazol-4-vPbenzoyl)-3 -nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide andN-(4-(5-methyl-l-pentyl-lH-pyrazol-4- yPbenzoyl)-3-nitro-4-((2-(phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 414B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 606 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 0.86 (t, 3H), 1.29 (m, 4H), 1.78 (m, 2H), 2.30 (s, 1.8H), 2.38 (s, 1.2H), 3.27 (t, 2H), 3.61 (dt, 2H), 4.01 (t, 2H), 7.01 (d, IH), 7.20 (t, IH), 7.31 (t, 2H), 7.40 (m, 4H), 7.90 (m, 3H), 7.99 (s, IH), 8.51 (d, IH), 8.54 (t, IH). Example 415 4-((2-adamantylmethyPamino)-N-(4-(5-fluoroquinolin-8-yPbenzoyl)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 255A for Example 108A in Example 389B. MS (ESI(-)) m/e 613 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.99 (dd, IH), 8.55 (m, 2H), 8.40 (t, IH), 7.97 (d, 2H), 7.92 (dd, IH), 7.78 (dd, IH), 7.72 (d, IH), 7.67 (dd, IH), 7.60 (d, 2H), 7.54 (dd, IH), 7.18 (d, IH), 3.14 (d, 2H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 416 . methyl 2-((4-((((4'-fluoro- 1 , 1 '-biphenyl-4-yPc-irbonyPamino sulfonyP-2- nitrophenvPamino)-3-(phenylthio)propylcarbamate The desired product was prepared by substituting methyl chloroformate for acetyl chloride in Example 310. MS (ESI(-)) m/e 637 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8:55 (d, IH), 8.30 (d, IH), 7.96 (d, 2H), 7.84 (dd, IH), 7.75 (m, 4H), 7.45 (m, IH), 7.35-7.10 (m, 8H), 4.06 (m, IH), 4.02 (m, 2H), 2.49 (s, 3H), remaining two protons buried under solvent peaks. Example 417 N-((2'-methoxy-4'-(methoxymethyl)-l,r-biphenyl-4-yl)carbonyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 417A methyl 4'-(hydroxymethyP-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylate A solution of Example 1221 (270 mg, 0.5 mmol), and sodium borohydride (80 mg) in methanol (5 mL) at room temperature was stirred for 30 minutes, dUuted with ethyl acetate (70 mL), washed with water (20 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product. Example 417B methyl 2'-methoxy-4'-(methoxymethyP- 1 , 1 '-biphenyl-4-carboxylate A solution of Example 417A (142 mg, 0.5 mmol) in THF (3 mL) at room temperature was treated with 60% sodium hydride in oU (40 mg, 1.0 mmol) and methyl iodide (0.30 mmol), stirred for 30 minutes, adjusted to pH <7 with 4M HCl in dioxane (0.5 mL), fUtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 10% ethyl acetate/hexanes to provide the desired product. Example 417C N-((2'-methoxy-4'-(methoxymethyl)-l,r-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 417B and Example 77B for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 606 (M-H) " ; 1H MR (300 MHz, DMSO-de) δ 8.72 (t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.89 (d, 2H), 7.54 (d, 2H), 7.37 (m, 2H), 7.28 (m, 3H), 7.18 (tt, IH), 7.06 (s, IH), 6.97 (d, IH), 4.45 (s, 2H), 3.76 (s, 3H), 3.66 (q, 2H), 3.33 (s, 3H), 3.20 (t, 2H). Example 418 tert-butyl 7-(4-(4-((((3-nitro-4-((2- (phenylt o)ethypamino)phenvPsulfonypamino)carbonyPphenyl)-3,6-dihydropyridin-l(2H)- yp-7-oxoheptylcarbamate The desired product was prepared by substituting BOC-7-aminoheptanoic acid for BOC-leucine in Example 378. MS (ESI(-)) m/e 764 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.72 (brt, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.55 (d, 2H), 7.40-7.15 (m, 6H), 6.75 (br t, IH), 6.45 and 6.42 (2m, IH), 4.18 and 4.12 (2d, 2H), 3.65 (m, 4H), 3.40-3.25 (m, 4H), 2.90 (m, 2H), 2.45 (m, 2H), 2.45 (m, 2H), 1.50 (m, 2H), 1.35 (s, 9H), 1.25 (m, 4H). Example 419 N-(4-(2-methyl-l-benzothien-5-yPbenzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 419A methyl 4-(2-methyl- 1 -benzothien-5-yPbenzoate The desired product was prepared by substituting 5-chloro-2-methylbenzothiophene for 5-chloro-2-methyl-l,3-benzoxazole in Example 54A. Example 419B 4-(2-methyl- 1 -benzothien-5-yl) benzoic acid The desired product was prepared by substituting Example 419A for Example 1A in Example IB. MS (ESI(-)) m/e 564 (M-H) " . Example 419C N-(4-(2-methyl- 1 -benzothien-5-yl)benzoyP-3-nitro-4-((2- (phenylthio)ethvPamino)benzenesulfonamide The desired product was prepared by substituting Example 419B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 602 (M-H) " ; l H NMR (300 MHz, DMSO-d 6 ) δ 2.59 (s, 3H), 3.28 (t, 2H), 3.61 (dt, 2H), 7.00 (d, IH), 7.19 (s, IH), 7.20 (d, IH), 7.30 (t, 2H), 7.40 (d, 2H), 7.50 (dd, IH), 7.68 (d, 2H), 7.90 (t, 2H), 7.96 (d, 2H), 8.02 (s, IH), 8.51 (t, IH), 8.52 (d, IH). Example 420 N-(3 -(4-hydroxy-4-methylcyclohex- 1 -en- 1 -yl)benzoyP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 420A 1 ,4-dioxaspiro(4.5)dec-7-en-8-yl trifluoroacetate The desired product was prepared by substituting l,4-dioxaspiro(4.5)decan-8-one for 4-tert-butylcyclohexanone in Example 5A. Example 420B methyl 4-(l ,4-dioxaspiro(4.5)dec-7-en-8-yl)benzoate The desired product was prepared by substituting Example 420A for Example 5A in Example 5B. Example 420C methyl 4-(4-oxocyclohex- 1 -en- 1 -ypbenzoate A solution of Example 420B (2.2 g) and p-toluenesulfonic acid (100 mg) in acetone (10 mL) was heated to reflux for 10 hours, fUtered through a pad of silica gel (20 g), and concentrated to provide the desired product. Example 420D methyl 4-(4-hydroxy-4-methylcyclohex- 1 -en- 1 -ypbenzoate A suspension of anhydrous cerium(III) chloride (2.71 g, 11 mmol) in THF (10 mL) at -78 °C was slowly treated wtih 1.5M methyUithium complexed with Hthium chloride in diethyl ether (6.7 mL), warmed to room temperatur over 2 hours, and added to a solution of Example 420C (1.15 g, 5.0 mmol) in THF (10 mL) at -78 °C. The reaction was graduaUy warmed to room temperature over 4 hours, diluted with ethyl acetate (100 mL), washed with water (45 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 10-30% ethyl acetate/hexanes to provide the desired product. Example 420E 4-(4-hydroxy-4-methylcyclohex- 1 -en- 1 -yPbenzoic acid The desired product was prepared by substituting Example 420D for Example 1 A in Example IB. Example 420F N-(3-(4-hydroxy-4-methylcvclohex-l-en-l-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethvPamino)benzenesulfonamide The desired product was prepared by substituting Example 420E and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m e 566 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.50 (d, 2H), 7.40-7.15 (m, 6H), 6.20 (m, IH), 3.70 (m, 2H), 2.40-0.90(m, 8H), 1.25 (s, 3H). Example 421 N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl) carbonyp-4-((3-(2-furylmethoxy)-2- (phenylthio)propyl)amino)-3-nitrobenzenesulfonamide and N-((4'-fluoro- 1 , 1 '-biphenyl-4- yl)carbonyP-4-((2-(2-furylmethoxy)-l-((phenyltl io)methyPethyPamino)-3- nitrobenzenesulfonamide Example 421 A 3-(2-furylmethoxy)-2-(phenylthio)propan-l-ol and l-(2-furylmethoxy)-3-(phenylthio)propan- 2-ol The desired products were prepared by substituting furfuryl glycidyl ether for cyclohexene oxide in Example 7A. Example 42 IB 2-((3-azido-2-(phenylthio)propoxy)methvP furan and 2-((2-azido-3- (phenylthio)propoxy)methyP furan The desired product was prepared by substituting Example 421 A for Example 7A in Example 7B. Example 42 IC N-(r4'-fluoro-l.r-biphenyl-4-yl)carbonvP-4-((3-(2-mrylmethoxy)-2- (phenylthio)propyl)amino)-3-nitrobenzenesulfonamide and -((4'-fluoro-l,r-biphenyl-4- yl)c-irbonyP-4-((2-(2-furylmethoxy)-l-((phenylthio)methyl)ethyl)amino)-3- nitrobenzenesulfonamide The desired compound was prepared by substituting Example 42 IB for Example 393B in Example 393C. MS (ESI(-)) m/e 660 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ), mixture of two isomers, ratio (2: 1) δ 8.81 (br t, 2/3H), 8.61, 8.59 (2d, IH), 8.51 (br d, 1/2H), 7.96 (2d, 2H), 7.92, 7.88 (2dd, IH), 7.78 (m, 4H), 7.60, 7.58 (2m, IH), 7.40-7.10 (m, 8H), 6.49 (m, 2H), 4.45 (s, 2H), 4.25 (m, 2/3H), 3.80-3.50 (m, 5H). Example 422 isobutyl 4-(4-((((3-nitro-4-((2- (phenylthio)ethyl) ammo)phenyl) sulfonyl) amino) carbonyPphenyPpiperazine- 1 -carboxylate The desired product was prepared by substituting isopropyl chloroformate for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 640 (M-H) " ; H NMR (300 MHz, DMSO-dg) δ 8.75 (t, IH), 8.59 (d, IH), 7.91 (dd, IH), 7.76 (d, 2H), 7.39-7.35 (m, 2H), 7.29-7.23 (m, 2H), 7.20-7.14 (m, 2H), 6.93 (d, 2H), 3.81 (d, 2H), 3.66 (q, 2H), 3.50-3.44 (m, 4H), 3.32-3.23 (m, 6H), 1.94-1.82 (m, IH), 0.90 (d, 6H). Example 423 N-(4-(5-methylpyridin-2-vPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting 2-chloro-5-methylpyridine for 2, 8- bistrifluoromethyl-3-chloroquinohne in Example 319. MS (ESI) m/e 549 (M+H) + , 547 (M- H) " ; ! H NMR (500 MHz, DMSO-d 6 ) δ 7.78 (t, IH), 8.63 (d, IH), 8.53 (d, IH), 8.17 (d, 2H), 7.98-7.93 (m, 4H), 7.74 (dd, IH), 7.37 (dt, 2H), 7.27 (td, 2H), 7.21 (d, IH), 7.17 (tt, IH), 3.67 (q, 2H), 3.27 (t, 2H), 2.35 (s, 3H). Example 424 3-nitro-4-((2-(phenyltMo)ethyl)-imino)-N-(4-(lH-pyrrol-l-yl)benzoyl)benzenesulfonamide The desired product was prepared by substituting 4-(N-pyrrolyl)benzoic acid and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 521 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 3.26 (t, 2H), 3.60 (dt, 2H), 6.27 (s, 2H), 7.00 (d, IH), 7.20 (t, IH), 7.31 (t, 2H), 7.40 (d, 2H), 7.42 (s, 2H), 7.52 (d, 2H), 7.89 (d, IH), 7.93 (d, 2H), 8.51 (d, IH), 8.52 (t, IH). Example 425 N-(4-(3-methyl-l-benzothien-5-yl)benzoyP-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 425A methyl 4-(3-methyl- 1 -benzothien-5-yPbenzoate The desired product was prepared by substituting 5-chloro-3-methylbenzothiophene for 5-chloro-2-methyl-l,3-benzoxazole in Example 54A. Example 425B 4-(3-methyl-l-benzothien-5-yl)benzoic acid The desired product was prepared by substituting Example 425A for Example 1A in Example IB. MS (ESI(-)) m e 267 (M-H) " . Example 425C N-(4-(3-methyl-l-benzothien-5-yPbenzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 425B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 602 (M-H) " ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.46 (s, 3H), 3.27 (t, 2H), 3.61 (dt, 2H), 7.00 (d, IH), 7.20 (t, IH), 7.31 (t, 2H), 7.41 (m, 3H), 7.70 (dd, IH), 7.72 (d, 2H), 7.90 (dd, IH), 7.99 (d, 2H), 8.02 (d, 2H), 8.51 (t, IH), 8.52 (d, IH). Example 426 N-((4'-fluoro- 1 , 1 '-biphenyl-4-vP carbonyl)-4-(Y(; 1 S)-3 -hvdroxy- 1 - ((phenylthio)methvPpropyl) amino)-3 -nitrobenzenesulfonamide Example 426A (3S)-3-((4-(aminosulfonyP-2-nitrophenyPamino)-4-(phenylthio)butanoic acid The desired product was prepared by substituting Fmoc-L-Asp(OtBu)-OH for Fmoc- D-Asp(OtBu)-OH in Examples 122A-122E. Example 426B N-((4'-fluoro- 1.1 '-biphenyl-4-vD carbonyl)-4-(((; 1 S)-3-hvdroxy- 1 - ((phenyltMo)methyPpropyPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 426A for Example 122E in Example 280. Example 427 N-((4'-(3-(dimethylamino)propyl)-2'-methoxy-l , 1 '-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 427A methyl 4'-(3-(dimethylamino)-3-oxopropyl)-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting dimethylamine for morphohne in Example 122M. Example 427B methyl 4'-(3-(dimethylamino)propyl)-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 427A for Example 122F in Example 122G. Example 427C N-((4'-(3-(dimethylamino)propyP-2'-methoxy-l , 1 '-biphenyl-4-y carbonvP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 427B and Example 77B for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 647 (M-H) " ; H NMR (500 MHz, methanol-d 4 ) δ 8.80 (d, IH), 8.02 (dd, IH), 7.83 (d, 2H), 7.59 (d, 2H), 7.36 (m, 2H), 7.26 (d, IH), 7.21 (tt, 2H), 7.16 (tt, IH), 7.06 (d, IH), 6.98 (d, IH), 6.92 (dd, IH), 4.06 (t, 2H), 3.80 (s, 3H), 3.69 (t, 2H), 3.28 (t, 2H), 3.15 (m, 2H), 2.08 (m, 2H), 2.01 (s, 3H), 1.99 (s, 3H). Example 428 4-((3-(dimethylamino)- 1 -((phenyltMo)methyPpropyPamino)-N-((4'-fluoro- 1 , 1 '-biphenyl-4- yl)carbonyl)-3-nitrobenzenesulfonamide Example 428A 4-((3-(dimethylamino)-l-((phenyltMo)methyPpropyPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Fmoc-DL-Asp(OtBu)-OH for Fmoc-D-Asp(OtBu)-OH in Examples 122A-122G. Example 428B 4-((3-(dimethylamino)- 1 -((phenylthio)methyl)propyPamino)-N-((4'-fluoro-l , 1 '-biphenyl-4- yl)c-ιrbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 428A for Example 3 A in Example 5D. MS (ESI(-)) m/e 621 (M-H) " ; 1H NMR (500 MHz, methanol-^) δ 8.72 (d, IH), 7.98 (m, 3H), 7.68 (m, 4H), 7.26 (m, 2H), 7.18 (tt, 2H), 7.11 (m, 3H), 7.02 (d, IH), 4.17 (m, IH), 3.40 (d, IH), 3.25 (m, 3H), 2.88 (s, 6H), 2.30 (m, IH), 2.20 (m, IH). Example 429 tert-butyl 3-( f 2-methoxy-4'-(( 1 (3-nitro-4-( ' (2- (phenylthio)ethyl)amino)phenyl)sulfonyl)amino)carbonyP- 1 , 1 '-biphenyl-4-yPpropanoate The desired product was prepared by substituting Example 122K and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 690 (M-H) " ; a NMR (300 MHz, DMSO-d 6 ) δ 8.79 (t, IH), 8.62 (d, IH), 7.94 (dd, IH), 7.88 (d, 2H), 7.57 (d, 2H), 7.37 (m, 2H), 7.30-7.14 (m, 5H), 7.02 (d, IH), 6.92 (dd, IH), 3.76 (s, 3H), 3.67 (q, 2H), 3.28 (d, 2H), 2.85 (t, 2H), 2.57 (t, 2H), 1.39 (s, 9H). Example 430 N-(4-(l-(cyclohexylmethyl)-2-methyl-lH-benzimidazol-5-vPbenzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 430A 4-bromo-N -(cyclohexylmethyp benzene- 1 ,2-diamine The desired product was prepared by substituting cyclohexylmethylamine for butylamine in Examples 166A and 166B. Example 430B 5-bromo- 1 -(cyclohexylmethyP-2-methyl- 1 H-benzimidazole The desired product was prepared by substituting Example 430A and acetic acid for Example 343A and valeric acid, respectively, in Example 343B. Example 43 PC 4-( 1 -(cyclohexylmethyl)-2-methyl- lH-benzimidazol-5-yPbenzoic acid The desired product was prepared by substituting Example 430B for 6-bromoindole in Example 4A. Example 430D N-(4-(l-(cyclohexylmethyP-2-methyl-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 430C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 682, 684 (M- H) " , (M+H) + ; aa NMR (300 MHz, DMSO-d 6 ) δ 1.03-1.25 (m, 4H), 1.44-1.98 (m, IH), 2.54 (s, 3H), 3.27 (t, 2H), 3.61 (dt, 2H), 4.04 (d, 2H), 6.99 (d, IH), 7.20 (tt, IH), 7.31 (td, 2H), 7.40 (dd, 2H), 7.50 (dd, IH), 7.56 (d, IH), 7.64 (d, 2H), 7.78 (s, IH), 7.89 (dd, IH), 7.95 (d, 2H), 8.53 (d, IH), 8.53 (t, IH). Example 431 N-((2'-methoxy-4'-(3-methoxypropyP- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 431 A methyl 4'-(3-hvdroxypropyl)-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 122L for Example 122E in Example 280A. Example 43 IB methyl 2'-methoxy-4'-(3-methoxypropyP- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 431A for Example 417A in Example 417B. Example 43 IC N-((2'-methoxy-4'~(3-methoxypropyl)- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 43 IB and Example 77B for Example 5C and Example 3 A, respectively, in Example 5D. MS (ESI(-)) m/e 634 (M-H) " ; a NMR (300 MHz, DMSO-de) δ 8.65 (t, IH), 8.57 (d, IH), 7.90 (dd, IH), 7.88 (d, 2H), 7.47 (d, 2H), 7.39 (m, 2H), 7.30 (tt, 2H), 7.20 (m, 2H), 7.09 (d, IH), 6.95 (d, IH), 6.86 (dd, IH), 3.76 (s, 3H), 3.64 (q, 2H), 3.45 (t, 2H), 3.26 (t, 2H), 3.25 (s, 3H), 2.64 (t, 2H), 1.85 (m, 2H). Example 432 N-f f4'-f4-(2.5-mmethoxyphenyl)- 1.3-oxazol-2-vP- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitro-4-(T2- (phenylthio)ethyPamino)benzenesulfonamide Example 432A 2-(4-bromophenyP-4-(2,5-dimethoxyphenyP- 1 ,3-oxazole The desired product was prepared by substituting 2-bromo-2',5'- dimethoxyacetophenone for 2-bromo-4'-methylacetophenone in Example 186B. MS (DCI) m/e 360, 362 (M+H) + ; ! H NMR (300 MHz, DMSO-d 6 ) δ 8.52 (s, IH), 8.02-7.99 (m, 2H), 7.80-7.77 (m, 2H), 7.66 (d, IH), 7.07 (d, IH), 6.93 (dd, IH), 3.91 (s, 3H), 3.79 (s, 3H). Example 432B ethyl 4'-(4-(2, 5-dimethoxyphenyP- 1 ,3 -oxazol-2-yl)- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 432A for Example 186B in Example 186C. MS (DCI) m/e 430 (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 8.54 (s, IH), 8.21-8.18 (m, 2H), 8.10-8.07 (m, 2H), 7.98-7.95 (m, 2H), 7.94-7.92 (m, 2H), 7.70 (d, IH), 7.09 (d, IH), 6.94 (dd, IH), 4.36 (q, 2H), 3.92 (s, 3H), 3.81 (s, 3H), 1.36 (t, 3H). Example 432C 4'-(4-(2,5-dimethoxyphenyl)-l ,3-oxazol-2-vP- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 432B for Example 186C in Example 186D. MS (DCI) m/e 402 (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 8.53 (s, IH), 8.19-8.18 (m, 2H), 8.07-8.06 (m, 2H), 7.96-7.95 (m, 2H), 7.91-7.89 (m, 2H), 7.70 (d, IH), 7.09 (d, IH), 6.94 (dd, IH), 3.92 (s, 3H), 3.81 (s, 3H). Example 432D N-(T4'-(4-(2,5-dimethoxyphenyP-l,3-oxazol-2-vP-l,r-biphenyl-4-vPcarbonyP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 432C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (DCI) m/e 737 (M+H) ; H NMR (300 MHz, DMSO-de) δ 12.55 (br s, IH), 8.81, (t, IH), 8.65 (d, IH), 8.54 (s, IH), 8.19-8.16 (m, 2H), 8.03-8.00 (m, 2H), 7.97-7.89 (m, 5H), 7.68 (d, IH), 7.39-7.36 (m, 2H), 7.30-7.18 (m, 4H), 7.08 (d, IH), 6.93 (dd, IH), 3.92 (s, 3H), 3.80 (s, 3H), 3.68 (q, 2H), 3.30 (q, 2H). Example 433 N-(4-(l-(cvclohexylmethyl)-lH-benzimidazol-5-yl)benzoyP-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 433 A 4-bromo-N -(cyclohexylmethyl)benzene-l ,2-diamine The desired product was prepared by substituting cyclohexylmethylamine for butylamine in Examples 166 A and 166B. Example 433B 5-bromo- 1 -(cyclohexylmethyp- 1 H-benzimidazole The desired product was prepared by substituting Example 433A for Example 170A in Example 170B. Example 433C N-(4-( 1 -(cyclohexylmethyp- 1 H-benzimidazol-5-yl)benzo yl)-3 -nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 433 B and Example 214E for 6-bromoindole and 4-(dihydroxyboryl)benzoic acid, respectively, in Example 4A. MS (ESI) m/e 668, 670 (M-H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 0.95-1.25 (m, 5H), 1.47-1.73 (m, 5H), 1.85 (m, IH), 3.28 (t, 2H), 3.62 (dt, 2H), 4.12 (d, 2H), 6.99 (d, IH), 7.19 (tt, IH), 7.30 (t, 2H), 7.39 (d, 2H), 7.45-7.62 (m, 2H), 7.66 (t, 2H), 7.85-7.94 (m, 4H), 8.22 (s, IH), 8.52 (d, IH), 8.54 (t, IH). Example 434 4-((2-azido- 1 -((phenylthio)methyl)ethyPamino)-N-((4'-fluoro- 1 , 1 '-biphenyl-4-yp carbonvP- 3 -nitrobenzenesulfonamide Example 434A methyl N-(4-(aminosulfonyl)-2-nitrophenyP-S-phenylcysteinate The desired product was prepared by substituting Example 175A and Example 122C for Example 175B and Example 175C, respectively, in Example 175D. Example 434B 4-((2-hydroxy- 1 -((phenylthio)methyl) ethyl) amino) -3 -nitrobenzenesulfonamide A solution of Example 434A (1.42 g, 3.45 mmol) in THF (10 mL) and methanol (1 mL) at room temperature was slowly treated with Hthium borohydride (100 mg), stirred for 3 hours, as dUuted with ethyl acetate (100 mL), washed with water (45 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (ESI(+)) m/e 384 (M+H). Example 434C 4-((2-azido-l-((phenylthio)methyl)ethyl)amino)-3-nitrobenzenesulfonamide A solution of Example 434B (1.01 g, 2.6 mmol) and N,N-diisopropylethylamine (0.70 mL, 4.0 mmol) in dichloromethane (5 mL) and DMF (5 mL) at room temperature was treated with methanesulfonyl chloride (0.22 mL, 2.90 mmol), stirred for 1 hour, and concentrated to remove the dichloromethane. The resulting DMF solution was treated with sodium azide (1.95 g, 30 mmol) and tetrabutylammonium iodide (100 mg), heated to 50 °C for 16 hours, dUuted with ethyl acetate (200 mL), washed with water (100 mL) and brine (50 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product. Example 434D 4-((2-azido- 1 -((phenylthio)methyP ethyl)amino)-N-((4'-fluoro- 1 , 1 '-biphenyl-4-yl) carbonyl)- 3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 434C for Example IC in Example ID. MS (ESI(-)) m/e 605 (M-H) " ; ! H NMR (300 MHz, DMSO-d 6 ) δ 8.59 (d, IH), 8.42 (d, IH), 7.97 (d, 2H), 7.92 (dd, IH), 7.78 (m, 4H), 7.35-7.1 (m, IH), 4.34 (m, IH), 3.82 (dd, IH), 3.69 (dd, IH), 3.37 (m, 2H). Example 435 tert-butyl (3R)-3-((4-((((4'-fluoro- 1 , 1 '-biphenyl-4-ypcarbonyPamino)sulfonyl)-2- nitrophenyPamino)-4-(phenylthio)butanoate The desired product was prepared by substituting Example 122D for Example IC in Example ID. MS (ESI(-)) m/e 664 (M-H) " ; 1H NMR (300 MHz, methanol-d 4 ) δ 8.73 (d, IH), 8.58 (d, IH), 7.95 (dd, IH), 7.93 (d, 2H), 7.70 (m, 4H), 7.28 (m, 2H), 7.23-7.12 (m, 5H), 6.98 (d, IH), 4.40 (m, IH), 2.78 (m, 2H), 1.36 (s, 9H), remaining two protons are buried under solvent peaks (3.35-3.28 ppm) . Example 436 8-(4-((((3-nitro-4-((2- (phenyltMo)ethyl)amino)phenyPsulfonyPamino)carbonyl)phenyl)quinoline-2-carboxylic acid Example 436A methyl 8-((trifluoroacetyl)oxy)quinoHne-2-carboxylate The desired product was prepared by substituting methyl 8-hydroxyquinoline-2- carboxylate for vanUlin in Example 122H. Example 436B 8-(4-rr(r3-nitro-4-rr2- (phenyltMo)ethyl)amino)phenyl)sulfonyl)amino)carbonyl)phenyl)quinoline-2-carboxylic acid The desired product was prepared by substituting Example 436A for Example 389A in Example 389B. MS (ESI(-)) m/e 627 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.8.77 (t, IH), 8.66 (d, IH), 8.52 (d, IH), 8.14 (d, 2H), 7.97 (d, 2H), 7.96 (dd, IH), 7.93 (dd, IH), 7.87 (d, 2H), 7.82 (dd, IH), 7.38 (m, 2H), 7.28 (tt, 2H), 7.22 (d, IH), 7.19 (tt, IH), 3.67 9q, 2H), 3.28 (t, 2H). Example 437 3-(2-methoxy-4'-((((3-nitro-4-((2-(phenylt o)ethyl)amino)phenyPsulfonyPamino)carbonyP- 1 , 1 '-biphenyl-4-yP-N.N-dimethylpropanamide The desired product was prepared by substituting Example 427A and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 661 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.79 (t, IH), 8.62 (d, IH), 7.94 (dd, IH), 7.88 (d, 2H), 7.57 (d, 2H), 7.37 (m, 2H), 7.30-7.14 (m, 5H), 7.02 (d, IH), 6.92 (dd, IH), 3.76 (s, 3H), 3.67 (q, 2H), 3.28 (d, 2H), 2.95 (s, 3H), 2.85 (t, 2H), 2.83 (s, 3H), 2.64 (t, 2H). Example 438 N-((4'-(hvdroxymethyP-2'-methoxy-l,r-biphenyl-4-vPcarbonyl)-3-nitro-4-((2- phenylthio)ethyPamino)benzenesulfonamide Example 438A. methyl 4'-(((tert-butyl(dimethvPsilvPoxy)methyp-2'-methoxy-l , 1 '-bipheny 1-4-carboxylate A solution of Example 417A (136 mg, 0.50 mmol), tert-butyldimethylsilyl chloride (91 mg, 0.60 mmol), and N,N~dnsopropylethylamine (129 mg, 1.0 mmol) in dichloromethane (5 mL) at room temperature was stirred for 3 hours, and filtered through a pad of sUica gel. The pad was rinsed with ether and the combined solutions were concentrated to provide the desired product. Example 438B N-((4'-(hydroxymethyl)-2'-methoxy-l , 1 '-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide A mixture of Example 438A (0.50 mmol) and IM LiOH (0.60 mL) in THF (2 mL) was heated to 50 °C, stirred for 3 hours, concentrated, dissolved in DMF (5 mL), and treated with a mixture of Example 77B (211 mg, 0.60 mmol), EDCI (193 mg, 1.0 mmol), and DMAP (50 mg). The mixture was stirred for 16 hours, treated with IM HF (3 mL), stirred for 3 hours, dUuted with ethyl acetate (100 mL), washed sequentially with IM HCl (10 mL), water (20 mL), and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 50-100% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 592 (M-H) " ; H NMR (300 MHz, DMSO-de) δ 8.79 (t, IH), 8.62 (d, IH), 7.92 (dd, IH), 7.89 (d, 2H), 7.54 (d, 2H), 7.37 (m, 2H), 7.28 (m, 3H), 7.18 (tt, IH), 7.06 (s, IH), 6.97 (d, IH), 4.54 (s, 2H), 3.76 (s, 3H), 3.66 (q, 2H), 3.20 (t, 2H). Example 439 N-(4-(l-benzyl-l,2,3,6-tetrahydropyridin-4-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 439A 1 -benzyl- 1 ,2,3 ,6-tetrahydropyridin-4-yl trifluoroacetate The desired product was prepared by substituting 1 -benzyl-4-piperidone for 4-tert- butylcyclohexanone in Example 5A. Example 439B methyl 4-( 1 -benzyl- 1 ,2,3 ,6-tetrahydropyridin-4-ypbenzoate The desired product was prepared by substituting Example 439A for Example 5A in Example 5B. MS (DCI (+)) m/e 308 (M+H) + . Example 439C N-(4-(l-benzyl-l,2,3,6-tetrahvdropyridin-4-yPbenzoyl)-3-nitro-4-((2- (phenylthio) ethyl) ammo)benzenesulfonamide The desired product was prepared by substituting Example 439B for Example 230B in Example 230C. MS (ESI(-)) m/e 627 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 8.55 (br t, IH), 8.50 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.55 -7.15 (m, 12H), 7.00 (d, IH), 6.35 (s, IH), 4.21 (s, 2H), 3.65 (m, 2H), 3.52-2.50 (m, 10H). Example 440 N-(4-( 1 -butyl- 1 H-benzimidazol-5-yl)beιιzoyl)-3 -nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 440A 5-bromo- 1 -butyl- 1 H-benzimidazole The desired product was prepared by substituting Example 166B and formic acid for Example 343A and valeric acid, respectively, in Example 343B. Example 440B N-(4-( 1 -butyl- 1 H-benzimidazol-5-yl)benzoyP-3 -nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 440A and Example 214E for 6-bromoindole and 4-(dihydroxyboryl)benzoic acid, respectively, in Example 4A. MS (ESI) m/e 628, 630 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 0.91 (t, 3H), 1.25 (qt, 2H), 1.79 (tt, 2H), 3.28 (t, 2H), 3.61 (dt, 2H), 4.27 (t, 2H), 6.99 (d, IH), 7.19 (tt, IH), 7.30 (td, 2H), 7.39 (dd, 2H), 7.47-7.62 (m, 3H), 7.66 (t, 2H), 7.88 (dd, IH), 7.92-7.98 (m, 2H), 8.26 (s, IH), 8.52 (d, IH), 8.53 (t, IH). Example 441 2-(2-methoxy-4'-((((3-nitro-4-((2-(phenyltlno)ethvPamino)phenyPsulfonyl)amino)carbonyl)- 1 , 1 '-biphenyl-4-yP-N,N-dimethylacetamide Example 441 A methyl 4'-(2-(dimethylamino)-2-oxoethvP-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting dimethylamine for 1- methylpiperazine in Example 328B. Example 44 IB 2-(2-methoxy-4'-((((3-nitro-4-((2-(phenylthio)ethypamino)phenvPsulfonyl)amino)carbonyP- 1 , 1 '-bipheny 1-4-yl) -N,N-dimethylacetamide The desired product was prepared by substituting Example 441 A and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m e 647 (M-H) " ; a NMR (300 MHz, DMSO-d 6 ) δ 8.79 (t, IH), 8.62 (d, IH), 7.93 (dd, IH), 7.88 (d, 2H), 7.57 (d, 2H), 7.47 (m, 2H), 7.30-7.15 (m, 5H), 6.99 (d, IH), 6.89 (dd, IH), 3.74 (s, 3H), 3.73 (s, 2H), 3.67 (q, 2H), 3.26 (d, 2H), 3.03 (s, 3H), 2.84 (s, 3H). Example 442 8-(4-((((4- r2-adamantylmethyl)amino)-3- nitrophenyPsulfonyl)amino)carbonyPphenyl)quinoHne-2-carboxylic acid The desired product was prepared by substituting Example 436A and Example 255A for Example 389A and Example 108A, respectively, in Example 389B. MS (ESI(-)) m/e 639 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.69 (d, IH), 8.62 (d, IH), 8.57 (t, IH), 8.14 (d, 2H), 7.97 (m, 3H), 7.93 (dd, IH), 7.87 (d, 2H), 7.73 (dd, IH), 7.36 (d, IH), 3.19 (d, 2H), 1.98 (m, 3H), 1.72-1.55 (m, 12H). Example 443 4-((2-(benzyloxy)- 1 -((phenylthio)methyl)ethyl)amino)-N-((4'-fluoro-l , 1 '-biphenyl-4- yPcarbonyP-3-nitrobenzenesulfonamide Example 443A methyl O-benzyl-N-(tert-butoxycarbonyPserinate A mixture of BOC-DL-Ser-OMe (434 mg, 2.0 mmol), benzyl bromide (513 mg, 3.0 mmol), and silver oxide (695 mg, 3.0 mmol) in dichloromethane (10 mL) at room temperature was stirred for 2 days, filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 20% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 308 (M-H) " . Example 443B tert-butyl 2-(benzyloxy)-l-(hydroxymethyl)ethylcarbamate The desired product was prepared by substituting Example 443 A for Example 175 A in Example 175B. MS (ESI(-)) m/e 280 (M-H) " . Example 443C tert-butyl 2-(benzyloxy)- 1 -((phenylthio)methypethylcai'bamate The desired product was prepared by substituting Example 443B for Example 122A in Example 122B. MS (ESI(-)) m/e 372 (M-H) " . Example 443D 4-((2-(benzyloxy)-l-((phenylthio)methyl)ethyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 443 C for Example 180A in Example 180B. MS (ESI(-)) m/e 472 (M-H) " . Example 443E 4-((2-(benzyloxy)- 1 -((phenylthio)methyPethyl)amino)-N-((4 '-fluoro- 1 , 1 '-biphenyl-4- vPc-ιrbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 443D for for Example IC in Example ID. MS (ESI(-)) m/e 670 (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.61 (d, IH), 8.60 (d, IH), 7.97 (d, 2H), 7.79 (dd, IH), 7.79 (m, 4H), 7.35-7.26 (m, 8H), 7.23 (m, 3H), 7.16 (m, IH), 4.50 (s, 2H), 4.27 (m, IH), 3.73 (dd, 1 H), 3,67 (dd, IH), 3.38 (m, 2H). Example 445 N-((4'-(2-hydroxyethyl)-2'-methoxy- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio) ethyl) ammo)benzenesulfonamide Example 445A methyl 2'-methoxy-4'-vinyl-l , 1 '-bipheny 1-4-carboxylate A suspension of methyltriphenylphosphonium bromide (785 mg, 2.2 mmoL) in THF (5 mL) was treated with IM lithium bis(trimethylsilyl)amide in THF (2.2 mL), stirred for 30 minutes, treated with a solution of Example 1221 (540 mg, 2.0 mmol) in THF (2 mL), stirred for 1 hour, and filtered through a pad of sUica gel (20 g). The pad was rinsed with 1 : 1 ether/dichlormethane and concentrated. The concentrate was purified by flash column chromatography on silica gel with 20-50% dichloromethane/hexanes to provide the desired product. Example 445B methyl 4'-(2-hydroxyethyl)-2'-methoxy-l , 1 '-biphenyl-4-carboxylate A solution of Example 445A (228 mg) and IM borane in THF (1.2 mL) in THF (2 mL) at room temperature was stirred for 5 hours, and treated sequentially with 2M sodium carbonate (1 mL) and 33% hydrogen peroxide (1 mL). The mixture was heated to 60 °C for 1 hour, dUuted with ethyl acetate (100 mL), washed with water (45 mL) and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 20-40% ethyl acetate/hexanes to provide the desired product. Example 445C methyl 4'-(2-((tert-butyl(dimethvPsilyl)oxy)ethyl)-2'-methoxy-l , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 445B for Example 417A in Example 438 A. Example 445D N-((4'-(2-hvdroxyethyl)-2'-methoxy- 1.1 '-biphenyl-4-yl)carbonvP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 445C for Example 438 A in Example 438B. MS (ESI(-)) m/e 606 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.64 (t, IH), 8.56 (d, IH), 7.90 (dd, IH), 7.88 (d, 2H), 7.46 (d, 2H), 7.38 (m, 2H), 7.30 (m, 2H), 7.20 (m, 2H), 7.10 (d, IH), 6.97 (d, IH), 6.88 (dd, IH), 4.65 (t, IH), 3.76 (s, 3H), 3.64 (m, 4H), 3.20 (t, 2H), 2.75 (t, 2H). Example 446 N-((2'-methoxy-4'-(2-methoxyethyP- 1 , 1 l -biphenyl-4-yl)carbonyl)-3 -nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide Example 446A methyl 2'-methoxy-4'-(2-methoxyethvP- 1 , 1 '-biphenyl-4-carboxylate The desired product was prepared by substituting Example 445B for Example 417A in Example 417B. Example 446B N-((2'-methoxy-4'-(2-methoxyethyP- 1 , 1 '-biphenyl-4-yl)carbohyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 446A and Example 77B for Example 5C and Example 3A, respectively, in Example 5D. MS (ESI(-)) m/e 620 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.64 (t, IH), 8.56 (d, IH), 7.90 (dd, IH), 7.88 (d, 2H), 7.46 (d, 2H), 7.38 (m, 2H), 7.30 (m, 2H), 7.20 (m, 2H), 7.10 (d, IH), 6.97 (d, IH), 6.88 (dd, IH), 3.78 (s, 3H), 3.64 (m, 4H), 3.44 (m, 2H), 3.28 (t, 23H), 3.13 (m, 2H), 3.08 (m, 2H), 2.69 (m, 2H), 2.03 (m, 2H), 1.53 (m, 2H). Example 447 N,N-dnsopropyl-4-(4-((((3-nitro-4-((2- (phenyltMo)ethyParnino)phenyPsulfonyl)amino)carbonyPphenyP-3,6-dihydropyridine- 1 (2H)-carboxamide The desired product was prepared by substituting diisopropylcarbamyl chloride for 4- morphoHnecarbonyl chloride in Example 317. MS (ESI(-)) m e 664 (M-H) " ; ! H NMR (300 MHz, DMSO-de) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.40-7.15 (m, 8H), 6.20 (d, IH), 3.70 (m, 2H), 2.40-1.20 (m, 10H), 0.85 (2s, 12H). Example 448 N-(4-(2-butyl-l-(cyclohexylmethyP-lH-benzimidazol-5-yPbenzoyl)-3-nitro-4-((2- (phenyltMo)ethyl)amino)benzenesulfonamide Example 448A 5-bromo-2-butyl- 1 -(cyclohexylmethyp- 1 H-benzimidazole The desired product was prepared by substituting Example 430A for Example 343A in Example 343B. Example 448B 4-(2-butyl- 1 -(cyclohexylmethyp- 1 H-benzimidazol-5-yl)benzoic acid The desired product was prepared by substituting Example 448A for 6-bromoindole in Example 4A. Example 448C N-(4-(2-butyl-l-(cyclohexylmethyP-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 448B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 724, 726 (M- H) " , (M+H) + ; aNMR (300 MHz, DMSO-d 6 ) δ 0.96 (t, 3H), 1.03-1.55 (m, 5H), 1.45 (qt, 2H), 1.47-1.73 (m, 5H) 1.82 (m, 3H), 2.86 (t, 2H), 3.27 (t, 2H), 3.63 (dt, 2H), 4.06 (d, 2H), 7.08 (d, IH), 7.19 (tt, IH), 7.29 (td, 2H), 7.39 (dd, 2H), 7.53 (dd, IH), 7.60 (d, IH), 7.71 (d, 2H), 7.86 (s, IH), 7.92 (dd, IH), 7.96 (d, 2H), 8.56 (d, IH), 8.53 (t, IH). Example 449 N-(4-(5-chloropyridin-2-vPbenzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting 2,4-dichloropyridine for 2,8- bistrifluoromethyl-3-chloroquinoHne in Example 319. MS (APCI(+)) m/e 569(M+H) ; (APCI(-)) m/e 567(M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.78 (t, IH), 8.74 (d, IH), 8.63 (d, IH), 8.19 (d, 2H), 8.15 (d,lH), 8.05 (dd, IH), 7.99 (d,2H), 7.94 (dd,lH), 7.36 (dt, 2H), 7.27 (td, 2H), 7.21 (d, IH), 7.18 (tt, IH), 3.68 (q, 2H), 3.25 (m, 2H). Example 450 N-((2'-methoxy-4'-(3-morphoHn-4-ylpropyl)-l , 1 '-biphenyl-4-yl)carbonyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 1220 and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 691 (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 10.15 (br s, IH), 8.79 (t, IH), 8.63 (d, IH), 7.93 (dd, IH), 7.88 (d, 2H), 7.57 (d, 2H), 7.37 (m, 2H), 7.26 (m, 3H), 7.23 (d, IH), 7.17 (tt, IH), 7.02 (d, IH), 6.92 (dd, IH), 3.76 (s, 2H), 3.75 (s, 3H), 3.67 (q, 2H), 3.56-3.52 (m, 6H), 3.47 ( , 2H), 3.26 (d, 2H). Example 451 N-((4'-(3-hydroxypropyP-2'-methoxy-l,r-biphenyl-4-yPcarbonyP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 451 A methyl 4'-(3-((tert-butyl(dimethyl)silyl)oxy)propyl)-2'-methoxy-l , r-biphenyl-4-carboxylate The desired product was prepared by substituting Example 431 A for Example 417A in Example 438 A. Example 45 IB 4'-(3-((tert-butyl(dimethyl)silyl)oxy)propyP-2'-methoxy-l.r-biphenyl-4-carboxylic acid A mixture of Example 451A (828 mg, 2.0 mmol) and IM LiOH (3 mL) in THF (10 mL) was heated to 50 °C, stirred for 3 hours, diluted with ethyl acetate, washed with saturated sodium monobasic phosphate (10 mL), dried (MgSO 4 ), filtered, and concentrated to provide the desired product. Example 45 IC N-((4'-(3-hydroxypropyl)-2'-methoxy-l , 1 '-biphenyl-4-yP carbonyl) -3 -nitro-4-((2- (phenylthio)ethvPamino)benzenesulfonamide A mixture of Example 451B (200 mg, 0.5 mmol), Example 77B (211 mg, 0.60 mmol), EDCI (193 mg, 1.0 mmol), and DMAP (50 mg) at room temperature was stirred for 16 hours, treated with IM HF (3 mL), stirred for 3 hours, diluted with ethyl acetate (100 mL), washed sequentially with IM HCl (10 mL), water (20 mL), and brine (10 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50-100% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 620 (M-H) " ; *H NMR (300 MHz, DMSO-d 6 ) δ 8.80 (t, IH), 8.63 (d, IH), 7.93 (dd, IH), 7.88 (d, 2H), 7.57 (d, 2H), 7.47 (m, 2H), 7.30-7.15 (m, 5H), 6.97 (d, IH), 6.88 (dd, IH), 3.76 (s, 3H), 3.64 (m, 2H), 3.45 (t, 2H), 3.20 (t, 2H), 2.64 (t, 2H), 1.75 (m, 2H). Example 452 4-((5-amino- 1 -((phenylthio)methyl)pentyPamino)-N-((4 '-fluoro- 1 , 1 '-biphenyl-4- yl)carbonyl)-3-mtroberizenesulfonamide A mixture of Example 345D (30 mg) and 4M HCl in 1,4-dioxane (3 mL) at room temperature was stirred for 5 hours and concentrated to provide the desired product as the HCl salt. MS (ESI(-)) m/e 621 (M-H) " ; 1H NMR (400 MHz, DMSO-d 6 ) δ 8.57 (d, IH), 8.31 (d, IH), 7.98 (d,2H), 7.89 (dd, IH), 7.68 (m, 4H), 7.73 (m, 3H), 7.35-7.13 (m, 7H), 4.12 (m, IH), 3.67 (m, 2H), 2.74 (m, 2H), 1.75(m, 2H), 1.53 (m, 2H), 1.40 (m, 2H). Example 453 (3R)-3-((4-((((4'-fluoro-l,l'-biphenyl-4-yl)carbonyl)amino)sulfonyP-2-nitrophenyl)amino)- N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting Example 122F for Example 1 C in Example ID. MS (ESI(-)) m/e 635 (M-H) " ; H NMR (500 MHz, methanol-d 4 ) δ 8.73 (d, IH), 8.09 (d, IH), 7.98 (d, 2H), 7.93 (dd, IH), 7.67 (m, 4H), 7.32 (m, 2H), 7.18 (m, 4H), 7.01 (d, IH), 4.44 (m, IH), 3.35 (m, 2H), 2.95 (dd (IH), 2.87 (s, 3H), 2.86 (s, 3H), 2.82 (dd, IH). Example 454 N-(4-(2-acetyl-3-methyl-l-benzothien-5-yl)benzoyl)-3-nitro-4-((2- i (phenylthio)ethyPamino)benzenesulfonamide Example 454A methyl 4-(2-acetyl-3 -methyl- l-benzothien-5-yl)benzoate The desired product was prepared by substituting l-(5-chloro-3 -methyl- 1-benzothien- 2-yl)ethanone for 5-chloro-2-methyl-l,3-in Example 54A. Example 454B 4-(2-acetyl-3 -methyl- 1 -benzothien-5-ypbenzoic acid The desired product was prepared by substituting Example 454A for Example 1A in Example IB. MS (ESI(-)) m/e 309(M)\ Example 454C N-(4-(2-acetyl-3-methyl-l-benzothien-5-yl)benzovP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 454B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 521 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 3.26 (t, 2H), 3.60 (dt, 2H), 6.27 (s, 2H), 7.00 (d, IH), 7.20 (t, IH), 7.31 (t, 2H), 7.40 (d, 2H), 7.42 (s, 2H), 7.52 (d, 2H), 7.89 (d, IH), 7.93 (d, 2H), 8.51 (d, IH), 8.52 (t, IH). Example 455 tert-butyl 4-(4-((((3-nitro-4-((2- (phenyltMo)ethyl)amino)phenyl)sulfonyl)anιino)carbonyl)phenyl)-3,6-dihydropyridine- 1 (2H)-carboxylate Example 455A tert-butyl 4-((trifluoroacetyl)oxy)-3,6-dihydropyridine-l(2H)-carboxylate The desired product was prepared by substituting tert-butyl-4-oxo- piperidinecarboxylate for 4-tert-butylcyclohexanone in Example 5A. Example 455B tert-butyl 4-(4-(methoxycarbonyPphenyP-3 ,6-dihy dropyridine- 1 (2H)-carboxylate The desired product was prepared by substituting Example 455A for Example 5A in Example 5B. MS (DCI (+)) m/e 318 (M+H) + . Example 455C tert-butyl 4-(4-((((3-nitro-4-((2- (phenyltMo)ethyPamino)phenyl)sulfonypamino)carbonyPphenyP-3,6-dihydropyridine- 1 (2H)-carboxylate A mixture of Example 455B (lg, 3.1 mmol) and LiOH (0.264mg 6.2 mmol) in THF (15 mL), methanol (2.5 mL), and water (1.5 mL) was heated to 50 °C for 3 hours and concentrated. The concentrate was dissolved in DMF (10 mL) and treated with a mixture of Example 77B (1.059g, 3 mmol), EDCI (1.146 g, 6 mmol), and DMAP (1.830, 15 mmol) in dichloroethane (10 mL), stirred for 16 hours, dUuted with ethyl acetate (250 mLO, washed sequentially with IN HCl (50 mL, water (100 mL) and brine (100 mL), dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 5% methanol/dichloromethane to provide the desired product. MS (ESI(-)) m/e 637 (M-H) " ; H NMR (300 MHz, DMSO-de) 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.55 (d, 2H), 7.40-7.15 (m, 6H), 6.35 (m, IH), 4.21 (d, 2H), 3.65 (m, 2H), 3.52 (t, 2H), 3.25 (m, 4H), 1.45 (s, 9H). Example 456 3-nitro-4-(r2-(;phenylthio)ethvPamino)-N-(4-((lR,4R)-l,7,7-trimethylbicyclo(2.2.1)hept-2- en-2-yPbenzoyl)beήzenesulfonamide The desired product was prepared by substituting Example 372B for Example 230B in Example 230C. MS (ESI(-)) m/e 590 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.78 (br t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.85 (d, 2H), 7.40-7.15 (m, 8H), 6.20 (d, IH), 3.70 (m, 2H), 2.40 (t, IH), 1.95 (m, 2H), 1.65 (m, 2H), 1.25 (m, 4H), 1.05 (s, 3H), 0.85 (2s, 6H). Example 457 3-((4-((((4'-fluoro-l,r-biphenyl-4-vPcarbonyl)amino)sulfonyl)-2-nitrophenyl)amino)-N,N- dimethyl-4-(phenylthio)butanamide Example 457A 3-((4-(an inosulfonyP-2-nitrophenyl)amino)-N,N-dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting Fmoc-DL-Asp(OtBu)-OH for Fmoc-D-Asp(OtBu)-OH in Examples 122A-F. Example 457B 3-((4-((((4'-fluoro-l,r-biphenyl-4-vPcarbonypamino)sulfonyl)-2-nitrophenyPamino)-N,N- dimethyl-4-(phenylthio)butanamide The desired product was prepared by substituting Example 457A for Example IC in Example ID. MS (ESI(-)) m/e 635 (M-H) " ; H NMR (500 MHz, methanol-d-t) δ 8.73 (d, IH), 8.09 (d, IH), 7.98 (d, 2H), 7.93 (dd, IH), 7.67 (m, 4H), 7.32 (m, 2H), 7.18 (m, 4H), 7.01 (d, IH), 4.44 (m, IH), 3.35 (m, 2H), 2.95 (dd (IH), 2.87 (s, 3H), 2.86 (s, 3H), 2.82 (dd, IH). Example 458 methyl N-(4-((((4'-fluoro-l,r-biphenyl-4-yl)carbonvPamino)sulfonvP-2-nitrophenyp-S- phenylcysteinate The desired product was prepared by substituting Example 434A for Example IC in Example ID. MS (ESI(-)) m/e 608 (M-H) " ; H NMR (300 MHz, DMSO-d 6 ) δ 8.70 (d, IH), 8.51 (d, IH), 7.96 (d, 2H), 7.90 (dd, IH), 7.75 (m, 3H), 7.66 (d, 2H), 7.32-7.25 (m, 4H), 7.20- 7.00 (m, 4H), 5.04 (m, IH), 3.70-3.57 (m, 2H), 3.59 (s, 3H). Example 459 N-(4-(4,4-dimethylpiperidin-l-yl)benzoyP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 119C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS(ESI(+)) m/e 569 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.77 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.72 (d, 2H), 7.37 (m, 2H), 7.28-7.12 (m, 4H), 6.92 (d, 2H), 3.67 (m, IH), 3.32 (m, 6H), 1.37 (t, 4H), 0.95 (s, 6H). Example 461 N-(4-(8-azaspiro(4.5)dec-8-yl)benzoyl)-3-nitro-4- (2- (pheny lthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting Example 257C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS(ESI(+)) m/e 569 (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 11.96 (s, IH), 8.77 (t, IH), 8.51 (d, IH), 7.88 (dd, IH), 7.71 (d, 2H), 7.40 (m, 2H), 7.30 (m, 2H), 7.18 (m, IH), 7.06 (d, IH), 6.85 (d, 2H), 3.62 (m, 2H), 3.30 (m, 6H), 1.59 (m, 4H), 1.48 (m, 8H). Example 462 N-((4'-fluoro- 1 , 1 '-biρhenyl-4-vP carbonvP-4-((Y 1 R)-3-morρhoHn-4-yl-3-oxo- 1 - ((phenylt o)methyl)propyl)amino)-3-nitrobenzenesulfonamide Example 462A 4-(((lR)-3-moφhoHn-4-yl-3-oxo-l-((phenylthio)methyl)propyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting moφholine for dimethylamine in Example 122F. Example 462B N-((4'-fluoro-l,r-biphenyl-4-yl)carbonyP-4-(((lR)-3-morphoHn-4-yl-3-oxo-l- ((phenyltMo)methyl)propyl)-ιmino)-3-nitroberιzenesulfonamide The desired product was prepared by substituting Example 462A for Example IC in Example ID. MS (ESI(-)) m/e 677 (M-H) " ; 1H NMR (300 MHz, methanol-c^) δ 8.79 (d, IH), 8.75 (d, IH), 7.94 (m, 3H), 7.70 (m, 4H), 7.30 (m, 2H), 7.24-7.13 (m, 5H), 7.01 (d, IH), 4.50 (m, IH), 3.62-3.52 (m, 4H), 3.52-3.46 (m, 4H), 3.37 (m, 2H), 3.00 (dd (IH), 2.85 (dd, IH). Example 463 N-((2'-methoxy-4'-(3-moφhoHn-4-ylpropyP- 1 , 1 '-biphenyl-4-yPcarbonyl)-4-((( lR)-3- moφhoHn-4-yl-l-((phenylthio)methyPpropyPamino)-3-nitrobenzenesulfonamide Example 463A 4-((( 1 R)-3 -moφhoHn-4-yl- 1 -((phenylthio)methyPpropyl) amino)-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 462A for Example 122F in Example 122G. Example 463B N-((2'-methoxy-4'-(3-moφhoHn-4-ylpropyP- 1 , 1 '-biphenyl-4-yl)carbonyι)-4-((( lR)-3- moφhohn-4-yl- 1 -((phenylthio)methyPpropyl)amino)-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 1220 and Example 463 A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 802 (M-H) " ; 1H NMR (500 MHz, methanol-c-Lt) δ 8.71 (d, IH), 7.95 (dd, IH), 7.90 (d, 2H), 7.52 (d, 2H), 7.29 (dd, 2H), 7.22 (d, IH), 7.14 (m, 3H), 6.96 (d, IH), 6.95 (s, IH), 6.89 (d, IH), 4.15 (m, IH), 3.88 (m, 4H), 3.78 (s, 3H), 3.76 (m, 4H), 3.37 (dd, IH), 3.24 (m, 4H), 3.11 (m, 2H), 2.94-2.80 (m, 4H), 2.76 (t, 2H), 2.21 (m, IH), 2.08 (m, 3H). Example 464 N-(4-(l-(2-moφhoHn-4-ylethyl)-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 464A 4-bromo-N -(2-moφhoHn-4-ylethvPbenzene-l ,2-diamine The desired product was prepared by substituting 4-(2-aminoethyl)moφholine for butylamine in Examples 166A and 166B. , Example 464B 5-bromo- 1 -(2-moφhoHn-4-ylethyl)- 1 H-benzimidazole The desired product was prepared by substituting Example 464A for Example 349A in Example 349B. Example 464C N-(4-(l-(2-moφhoUn-4-ylethyP-lH-benzimidazol-5-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 464B and Example 214E for 6-bromoindole and 4-(dihydroxyboryl)benzoic acid, respectively, in Example 4. MS (ESI) m/e 685, 687 (M-H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 2.46 (t, 4H), 2.72 (t, 2H), 3.28 (t, 2H), 3.55 (t, 4H), 3.62 (dt, 2H), 4.39 (t, 2H), 7.02 (d, IH), 7.20 (tt, IH), 7.30 (t, 2H), 7.40 (d, 2H), 7.58 (dd, IH), 7.66 (d, 2H), 7.70 (d, IH), 7.91 (dd, IH), 7.95 (d, IH), 7.97 (d, 2H), 8.27 (s, IH), 8.52 (t, IH), 8.55 (d, IH). Example 465 N-((2'-methoxy-4'-(3-moφhoHn-4-ylρropyl)-l.l'-biphenyl-4-yl)carbonvP-4-( ' (αR)-3-r4- methylpiperazin-l-vP-3-oxo-l-((phenylthio)methyPpropyl)amino)-3- nitrobenzenesulfonamide Example 465A 4-(((lR)-3-(4-methylpiperazin-l-yl)-3-oxo-l-((phenylthio)methyl)propyPamino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting 1-methylpiperidine for dimethylamine in Example 122F. Example 465B N-((2'-methoxy-4'-(3-moφhoHn-4-ylpropyP-l,r-biphenyl-4-yl)carbonyl)-4-(((lR)-3-(4- methylpiperazin-l-yP-3-oxo-l-((phenylthio)methyl)propyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 1220 and Example 465A for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 829 (M-H) " ; T NMR (500 MHz, methanol-d 4 ) δ 8.71 (d, IH), 7.95 (dd, IH), 7.90 (d, 2H), 7.52 (d, 2H), 7.29 (dd, 2H), 7.22 (d, IH), 7.14 (m, 3H), 6.96 (d, IH), 6.95 (s, IH), 6.89 (d, IH), 4.40 (m, IH), 3.78 (s, 3H), 3.76 (m, 4H), 3.52 (m, 4H), 3.37 (dd, IH), 3.20 (s, 3H), 2.95 (dd, IH), 2.68 (m, 4H), 2.58 (m, 4H), 2.50 (m, 4H), 2.18 (m, 2H), 1.90 (m, 2H). Example 466 N-(4-(4,4-dimethylpiperidin-l-yPbenzoyl)-4-(((lR)-3-(4-methylpiperazin-l-vP-3-oxo-l- ((phenylthio)methyl)propyPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 119C and Example 465A for Example IB and Example IC, respectively, in Example ID. MS(ESI(+)) m/e 709 (M+H) + ; H NMR (500 MHz, methanol-c^) δ 8.71 (d, IH), 8.65 (d, IH), 7.90 (dd, IH), 7.77 (d, 2H), 7.31 (m, 2H), 7.17 (m, 3H), 6.88 (m, 3H), 3.82 (m, IH), 3.53 (m, 4H), 3.33 (m, 4H), 3.05 (m, IH), 2.95 (dd, IH), 2.83 (m, 2H), 2.40 (m, 4H), 2.25 (s, 3H), 1.47 (m, 4H), 0.97 (s, 6H). Example 467 4-(((lR)-5-an ino-l-((phenylsulfonyPmethyl)pentyPamino)-N-((2'-methoxy-4'-(3-moφhoHn- 4-ylpropyP- 1 , 1 '-biphenyl-4-yl)carbonyP-3-nitrobenzenesulfonamide A mixture of Example 194 (100 mg) in acetonitrUe (5 mL) and saturated aqueous sodium periodate (3 mL) at room temperature was stirred for 3 days and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 0-3 % concentrated aqueous ammonia in 1: 1 isopropanol/dichloromethane, and purified a second time by reverse phase column chromatography with 0-100% acetonitrUe/water to provide the desired product. MS (ESI(-)) m/e 792 (M-H) " ; 1HNMR (500 MHz, DMSO-d 6 ) δ 8.41 (IH), 7.92 (d, 2H), 7.84 (m,2H), 7.65 (d, 2H), 7.56 (m, 3H), 7.41 (m, 3H), 7.20 (d, 1H), 6.96 (d, IH), 6.95 (s, IH), 6.87 (d, IH), 4.24 (m, IH), 4.05 (dd, IH), 3.63 (m, 4H), 2.72 (m, 2H), 2.63 (t, 2H), 1.86 (m, 2H), 1.70 (m, 2H), 1.48 (m, 2H), 1.33 (m, 2H). Example 468 N-(4-(5-(3-moφhoHn-4-ylpropyPquinolin-8-yl)benzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 468A methyl 4-(5-(3-moφhoHn-4-yl-3-oxopropyl)quinolin-8-yl)benzoate The desired product was prepared by substituting moφhohne for 1-methylpiperazine in Example 201 J. Example 468B methyl 4-(5-(3-moφhoHn-4-ylpropyPquinolin-8-yl)benzoate The desired product was prepared by substituting Example 468A for Example 362A in Example 248A. Example 468C 4-(5-(3-moφhoHn-4-ylpropyl)quinolin-8-yl)benzoic acid The desired product was prepared by substituting Example 468B for Example 1 A in Example IB. Example 468D N-(4-(5-(3-moφhoUn-4-ylpropyPquinolin-8-ypbenzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 468C and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 710, 712 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.02 (m, 2H), 2.98 (m, 4H), 3.15 (t, 2H), 3.28 (t, 2H), 3.31 (t, 2H), 3.63 (dt, 2H), 3.72 (m, 4H), 7.06 (d, IH), 7.20 (tt, IH), 7.31 (tt, 2H), 7.40 (dt, 2H), 7.54-7.64 (m, 4H), 7.71 (d, IH), 7.92 (dd, IH), 7.96 (d, 2H), 8.56 (d, IH), 8.61 (dd, IH), 8.90 (dd, IH). Example 469 tert-butyl 1 '-(4-f (((3-nitro-4-((2- (phenyltMo)ethyl)amino)phenyPsulfonyl)amino)carbonyPphenyl)-4,4'-bipiperidιne-l- carboxylate The desired product was prepared by substituting 4-(l'-(tert-butoxycarbonyl)-4,4'- bipiperidin-l-yl)benzoic acid and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(-)) m/e 722 (M-H) " ; *H NMR (500 MHz, DMSO-d 6 ) δ 8.72 (t, IH), 8.58 (d, IH), 7.90 (dd, IH), 7.72 (d, 2H), 7.37 (d, 2H), 7.25 (t, 2H), 7.19-7.14 (m, 2H), 6.89 (d, 2H), 3.93 (br t, 4H), 3.66 (q, 2H), 3.28 (t, 2H), 2.74 (t, 2H), 2.66-2.54 (m, 2H), 1.68 (dd, 4H), 1.38 (s, 9H), 1.24-1.17 (m, 4H), 1.07-0.96 (m, 2H). Example 470 3-nitro-N-(4-(4-(phenylsulfonyl)piperazin- 1 -yPbenzoyl)-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting benzenesulfonyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 680 (M-H) " ; H NMR (500 MHz, DMSO-de) δ 12.01 (s, IH), 8.75 (t, IH), 8.59 (d, IH), 7.90 (dd, IH), 7.78-7.63 (m, 7H), 7.36 (d, 2H), 7.25 (t, 2H), 7.19-7.14 (m, 2H), 6.91 (d, 2H), 3.66 (q, 2H), 3.39-3.42 (m, 4H), 3.28 (t, 2H), 3.01-2.97 (m, 4H). Example 471 4-(((lR)-5-((aminocarbonyPamino)-l-((phenylthio)methyPpentyPamino)-N-(4-(8- azaspiro(4.5)dec-8-yl)benzoyl)-3-nitrobenzenesulfonamide A solution of Example 287 (60mg, 0.1 mmol) and potassium cyanate (20mg, 0.25 mmol) in methanol (1 mL) was stirred at 55 °C for 1.5 hours, cooled to room temperature, treated with water, and extracted with dichloromethane. The combined extracts were washed with saturated sodium bicarbonate, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by reverse phase HPLC with 0-100% acetonitrUe/water containing 0.1 % TFA to provide the desired product. MS (ESI(+)) m/e 709 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 11.97 (s, IH), 8.53 (d, IH), 8.32 (d, IH), 7.85 (dd, IH), 7.73 (d, 2H), 7.25-7.10 (m, 6H), 6.93 (d, 2H), 5.90 (s, IH), 4.10 (m, IH), 3.34 (m, 6H), 2.91 (t, 2H), 1.75 (m, 2H), 1.59 (m, 4H), 1.42 (m, 8H), 1.34 (m, 4H). Example 472 tert-butyl 4-((4-(((4-(8-azaspfro(4.5)dec-8-yPbenzoyl)amino)sulfonyP-2-nitrophenvPamino)- 4-((phenylthio)methyl)piperidine- 1 -carboxylate Example 472A tert-butyl 4-(((9H-fluoren-9-ylmethoxy)carbonyl)amino)-4-(hvdroxymethyl)piperidine- 1 - carboxylate The desired product was prepared by substituting l-(tert-butoxycarbonyl)-4-(((9H- fluoren-9-ylmethoxy)carbonyl)amino)piperidine-4-carboxyHc acid for Fmoc-D-Asp(OtBu)- OH in Example 122A. MS (ESI) m/e 451, 453 (M-H) " , (M+H) + . Example 472B tert-butyl 4-((4-(aminosulfonyl)-2-nitrophenvPamino)-4-(hydroxymethyPpiperidine- 1 - carboxylate The desired product was prepared by substituting Example 472A for Example 122B in Example 122D. MS (ESI(-)) m/e 429 (M-H) " . Example 472C tert-butyl 4-((4-(aminosulfonyl)-2-nitrophenyPamino)-4-((phenylthio)methyl)piperidine- 1 - carboxylate The desired product was prepared by substituting Example 472B for N-(tert- butoxycarbonyl)-L-serine methyl ester in Example 133 A. MS (ESI(-)) m/e 521 (M-H) " . Example 472D tert-butyl 4-((4-(((4-(8-azaspiro(4.5)dec-8-yl)benzoyl)amino)sulfonyl)-2-nitrophenyPamino)- 4-((phenylthio)methyl)piperidine- 1 -carboxylate The desired product was prepared by substituting Example 472C and Example 257C for Example IC and Example IB, respectively, in Example ID. MS (ESI) m e 762, 764 (M- H) " , (M+H) + ; a NMR (300 MHz, DMSO-d 6 ) δ 1.39 (s, 9H), 1.41 (m, 4H), 1.48 (m, 4H), 1.59 (m, 4H), 1.79 (dt, 2H), 2.22 (br d, 2H), 2.99 (m, 2H), 3.21 (m, 4H), 3.61 (s, 2H), 3.72 (br d, 2H), 6.81 (d, 2H), 6.95 (m, IH), 7.02 (td, 2H), 7.21 (m, 3H), 7.74 (d, 2H), 7.80 (dd, IH), 8.24 (br s, IH), 8.41 (d, IH). Example 473 N-(4-(5-(3-(4-methylpiperazin-l-yl)propyPquinoUn-8-yl)benzoyP-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 473A methyl 4-(5-(3-(4-methylpiperazin- 1 -yl)propyl)quinoHn-8-yl)benzoate The desired product was prepared by substituting Example 201 J for Example 362A in Example 248A. Example 473B 4-(5-(3-(4-methylpiρerazin-l-yl)propyPquinolin-8-yl)benzoic acid The desired product was prepared by substituting Example 473A for Example 1 A in Example IB. Example 473 C N-(4-(5-(3-(4-methylpiperazin-l-yPpropyl)quinolin-8-ypbenzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 473B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 723, 725 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 1.89 (m, 2H), 2.28 (s, 3H), 2.50 (m, 8H), 3.12 (t, 2H), 3.27 (t, 2H), 3.29 (t, 2H), 3.61 (dt, 2H), 6.98 (d, IH), 7.20 (tt, IH), 7.32 (tt, 2H), 7.41 (dd, 2H), 7.52-7.61 (m, 4H), 7.68 (d, 2H), 7.89 (dd, IH), 7.96 (d, 2H), 8.52 (d, IH), 8.58 (dd, IH), 8.89 (dd, IH). Example 474 N-((2'-methoxy-4'-(3-moφhoHn-4-ylpropyl)-l , 1 '-biphenyl-4-yl)carbonyP-3-nitro-4-((4- ((phenylthio)methyl)piperidin-4-yl)amino)benzenesulfonamide The desired product was prepared by substituting Example 472C and Example 1220 for Example IC and Example IB, respectively, in Example ID. The product was treated with TFA (5 mL), stirred for 90 minutes, concentrated, and concentrated again to provide the desired product. MS (ESI) m/e 758, 760 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.89-2.08 (m, 4H), 2.65 (dt, 2H), 3.00 (m, 2H), 3.22 (br d, 2H), 3.65 (s, 2H), 3.74 (m, 4H), 3.76 (s, 3H), 6.88 (d, IH), 6.96 (s, IH), 7.05 (m, 2H), 7.23 (m, 4H), 7.41 (d, 2H), 7.85 (dd, IH), 7.91 (d, 2H), 8.14 (s, IH), 8.42 (d, IH). Example 475 4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyl)propyPamino)-N-(4-(3,3- dimethylpyrroHdin-l-yPbenzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 122G and Example 247C for Example IC and Example IB, respectively, in Example ID. MS (ESI(+)) m/e 626 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 11.92 (s, IH), 9.42 (s, IH), 8.55 (d, IH), 8.30 (d, IH), 7.87 (dd, IH), 7.73 (d, 2H), 7.25-7.10 (m, 6H), 6.50 (d, 2H), 4.18 (m, IH), 3.40 (m, 4H), 3.15 ( , 2H), 3.07 (s, 2H), 2.74 (d, 6H), 2.14 (m, 2H), 1.77 (t, 2H), 1.08 (s, 6H). Example 476 4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyl)propyPamino)-N-(4-(4-ethyl-4- methylpiperidin- 1 -yl)benzoyP-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 122G and Example 123C for Example IC and Example IB, respectively, in Example ID. MS (ESI(+)) m/e 654 (M+H) + ; 2 H NMR (500 MHz, DMSO-d 6 ) δ 12.01 (s, IH), 9.41 (s, IH), 8.55<d, IH), 8.31 (d, IH), 7.87 (dd, IH), 7.73 (d, 2H), 7.25-7.10 (m, 6H), 6.93 (d, 2H), 4.17 (m, IH), 3.45 (m, 2H), 3.40 (d, 2H), 3.26-3.10 (m, 6H), 2.74 (d, 6H), 2.14 (m, 2H), 1.38 (m, 4H), 1.28 (m, 2H), 0.90 (s, 3H), 0.80 (t, 3H). Example 477 N-(4-(8-azaspiro(4.5)dec-8-yl)benzoyP-4-(((lR)-5-(dimethylamino)-l- ((phenylsulfinyl)methyl)pentyl)amino)-3-nitrobenzenesulfonamide A solution of Example 124F (30 mg, 0.04 mmol) and sodium periodate (46 mg, 0.22 mmol) in acetonitrUe (0.5 mL), dichloromethane (0.5 mL), and water (0.5 mL) was stirred at room temperature for 24 hours, treated with water, and extracted with dichloromethane. The combined extracts were dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 80% ethyl acetate/10% + 1 water/10% formic acid to provide the desired product. MS (ESI(+)) m/e 710 (M+H) ; H NMR (500 MHz, DMSO-d 6 ) δ 8.50 (d, 0.5H), 8.40 (d, 0.5H), 8.35 (d, 0.5H), 8.21 (s, IH), 7.94 (d, 0.5H), 7.90 (dd, 0.5H), 7.82 (dd, 0.5H), 7.71 (d, 2H), 7.70 (d, IH), 7.55 (m, 2H), 7.40 (m, IH), 7.20 (m, IH), 6.80 (d, 2H), 2.29 (m, IH), 2.18 (d, 6H), 1.91 (s, 6H), 1.68 (m, IH), 1.59 (m, 4H), 1.49 (m, 4H), 1.45-1.30 (m, 6H). Example 478 N~l~-((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-vPbenzoypamino)sulfonyl)-2- nitrophenyl)amino)-6-(phenylthio)hexyl)-N~2~,N~2 — dimethylglycinamide A mixture of Example 287 (33 mg, 0.05 mmol), N,N-dimethyglycine (10.3 mg, 0.10 mmol), EDCI (20 mg, 0.10 mmol) and HOBT (20 mg, 0.15 mmol) in DMA (0.6 mL) and dichloroethane (0.3mL) at room temperature was stirred for 18 hours and concentrated. The concentrate was dissolved in 1: 1 DMSO/methanol (1 mL) and loaded on a Nova-Pak HR C- 18, 6 μM, 60A, 40 x 100mm preparative HPLC column (eluted with 10-95% acetonitrUe/water containing 0.1% TFA). The purified compound was dissolved in 1 : 1 dichloromethane/methanol (1 mL), treated with 2M HCl in diethyl ether (1 mL), and concentrated to provide the hydrochloride salt. MS (ESI) m/e 751.3, 749.4 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-de) δ 8.53 (d, IH), 8.41 ( m, IH), 8.29 (d, IH), 7.86 (dd, IH), 7.73 (d, 2H), 7.25-7.09 (m, 5H), 6.92 (d, 2H), 4.12 (m, IH), 3.80 (s, 2H), 3.34 (m, 4H), 3.10 (d, 2H), 2.75 (s, 6H), 1.78 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 12H). Example 479 N-((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yPbenzoyl)amino)sulfonyl)-2-nitrophenypamino)- 6-(phenylthio)hexyPcyclopropanecarboxamide The desired product was prepared by substituting cyclopropanecarboxylic acid for N,N-dimethyglycine in Example 478. MS (ESI) m/e 734.3, 732.4 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-de) δ 8.53 (d, IH), 8.30 (d,lH), 7.93 (m, IH), 7.84 (dd, IH), 7.73 (d, 2H), 7.25-7.09 (m, 5H), 6.92 (d, 2H), 4.12 (m, IH), 3.34 (m, 4H), 3.01 (m, 2H), 1.78 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 12H), 0.61-0.56 (m, 5H). Example 480 r4R)-4-((4-( ((2'-methoxy-4'-(3-moφhoUn-4-ylpropyP-l,r-biphenyl-4- yPc-ιrbonyPamino)sulfonyl)-2-nitrophenypamino)-N,N-dimethyl-5-(phenyltMo)pentanamide Example 480A tert-butyl (2E,4R)-4-((tert-butoxycarbonyl)amino)-5-(phenylthio)pent-2-enoate Example 134A (5.74 g, 20.4 mmol) in THF (25 mL) at 0 °C was treated with a solution of (tert-butoxycarbonylmethylene)triphenylphosphorane (8.47 g, 22.5 mmol) in THF (25 mL), warmed to room temperature, stirred for 90 minutes, treated with hexanes (50 mL), filtered through a pad of silica gel, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 15% ethyl acetate/hexanes to provide the desired product. MS (ESI(-)) m/e 378 (M-H) " . Example 480B (4R)-4-((tert-butoxycarbonyl)amino)-5-(phenylthio)pentanoic acid A mixture of Example 480A (5g, 13.2 mmol) and Wilkinson's catalyst (1 g) in tolune (125 mL) was stirred under H 2 at 60 °C for 18 hours, cooled, filtered through sihca gel, and concentrated. The concentrate was dissolved in 3: 1: 1 THF/water/MeOH (150 mL), treated with with a 10-fold excess of LiOH, and stirred for 24 hrs. The mixture was poured into saturated NaH 2 PO 4 (200 mL) and extracted three times with ethyl acetate (200 mL). The combined extracts were washed with brine, dried (Na 2 SO 4 ), filtered, and concentrated to provide the desired product. MS (ESI) m/e 324, 326 (M-H) " , (M+H) + . Example 480C tert-butyl ( 1 R)-4-(dimethylamino)-4-oxo- 1 -((phenylthio)methvPbutylcarbamate The desired product was prepared by substituting Example 480B for Example 122E in Example 122F. MS (ESI) m/e 351, 353 (M-H) " , (M+H) + . Example 480D (4R)-4-((4-(ammosulfonyl)-2-mtrophen^ The desired product was prepared by substituting Example 480C for Example 133 A in Examples 133B and 133C. MS (ESI) m/e 451, 453 (M-H) " , (M+H) + . Example 480E (4R)-4-((4-((((2'-methoχy-4'-(3-moφholin-4-ylpropyP- 1 , 1 '-biphenyl-4- yPcarbonyPamino)sulfonyl)-2-nitrophenyl)amino)-N,N-dimethyl-5-(phenylthio)pentanamide The desired product was prepared by substituting Example 480D and Example 1220 for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 788, 790 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 1.78 (m, 2H), 1.95 (m, 2H), 2.35 (m, 2H), 2.40 (t, 4H), 2.62 (t, 2H), 2.82 (s, 3H), 2.96 (s, 3H), 3.30 (dd, IH), 3.36 (dd, IH), 3.58 (t, 4H), 3.76 (s, 3H), 4.07 (m, IH), 6.85 (d, IH), 6.95 (d, 2H), 7.18 (t, 2H), 7.23 (t, 2H), 7.31 (d, 2H), 7.40 (d, 2H), 7.82 (dd, IH), 7.90 (d, 2H), 7.95 (d, IH), 8.15 (d, IH), 8.48 (d, IH). Example 481 N-f(2'-methoxy-4'-(3-moφholin-4-ylpropyP-l,r-biphenyl-4-yPcarbonyP-4-(((lR)-3-(4- methylpiperazin- 1 -yl)- 1 -((phenylthio)methyl)propyPamino)-3-nitrobenzenesulfonamide Example 481 A 4-(((lR)-3-(4-methylpiperazin-l-vP-l-((phenylthio methyl)propyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 465A for Example 122F in Example 122G. MS (ESI(+)) m/e 480 (M+H) + . Example 48 IB N-((2'-methoxy-4'-(3-moφhoHn-4-ylpropyP- 1 , 1 '-biphenyl-4-yl)carbonvP-4-((( lR)-3-(4- . methylpiper--zin-l-yP-l-((phenyltMo)methyl)propyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 481 A and Example 1220 for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 815, 817 (M- H) " , (M+H) + ; aT NMR (300 MHz, DMSO-d 6 ) δ 1.52 (m, 2H), 1.82 (m, 2H), 2.21 (m, 2H), 2.40 (t, 4H), 2.48 (t, 2H), 2.80 (m, 4H), 3.04 (m, 4H), 2.98 (dd, IH), 3.05 (dd, IH), 3.53 (s, 3H), 3.58 (t, 4H), 3.62 (s, 3H), 3.91 (m, IH), 6.65 (d, IH), 6.78 (m, 2H), 6.95 (t, IH), 6.99 (m, 3H), 7.07 (d, 2H), 7.20 (d, 2H), 7.62 (dd, IH), 7.67 (d, 2H), 8.05 (d, IH), 8.26 (d, IH). Example 482 3-(2-me1hoxy^'-((((4^ ((phenyltMo)methyl)propyl)arnino)-3-nitrophenyl)sulfonyPamino)carbonyl)-l,r-biphenyl-4- yl)-N,N-dimethylpropanamide Example 482A 4'-(3-(dimethylamino)-3-oxopropyl)-2'-methoxy-l,r-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 427A for Example 1 A in Example IB. Example 482B 3-(2-methoxy-4'-((((4-(((lR)-3-(4-methylpiperazin-l-vP-l- ((phenyltMo)methyl)propyl)an ino)-3-nitrophenyl)sulfonyl)amino)carbonyl)-l,r-biphenyl-4- yl)-N,N-dimethylpropanamide The desired product was prepared by substituting Example 482A and Example 481 A for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 787, 789 (M- H) " , (M+H) + ; l H NMR (300 MHz, DMSO-d 6 ) δ 1.90 (m, 2H), 2.50 (m, 2H), 2.64 (m, 4H), 2.71 (t, 2H), 2.82 (s, 3H), 2.84 (m, 2H), 2.95 (s, 3H), 3.00 (dd, 2H), 3.34 (s, 3H), 3.36 (m, 4H), 3.76 (s, 3H), 4.18 (m, IH), 5.21 (t, IH), 6.90 (d, IH), 7.01 (s, IH), 7.14 (m, 2H), 7.21 (m, 3H), 7.29 (d, 2H), 7.49 (d, 2H), 7.90 (d, 2H), 8.25 (d, IH), 8.52 (d, IH). Example 483 3 -(2-methoxy-4'-((((4-((( 1 R)-3-(4-methylρiperazin- 1 -yl)-3-oxo- 1 - ((phenylt o)methyppropyl)amino)-3-nitrophenvPsulfonypamino)carbonyl)-l , 1 '-biphenyl-4- yP-N,N-dimethylpropanamide The desired product was prepared by substituting Example 482A and Example 465A for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 801, 803 (M- H) " , (M+H) + ; ! H NMR (300 MHz, DMSO-d 6 ) δ 2.62 (m, 4H), 2.63 (t, 2H), 2.76 (dd, IH), 2.81 (m, 2H), 2.82 (s, 3H), 2.95 (s, 3H), 3.00 (m, 2H), 3.31 (s, 3H), 3.36 (m, 4H), 3.40 (m, IH), 3.76 (s, 3H), 4.34 (m, IH), 6.83 (d, IH), 6.99 (s, IH), 7.19 (t, 2H), 7.25 (t, 2H), 7.32 (d, IH), 7.39 (d, 2H), 7.59 (d, IH), 7.80 (d, IH), 7.88 (d, 2H), 7.95 (d, IH), 8.46 (d, IH), 8.55 (d, IH). Example 484 4-(((lR)-4-(dimethylamino)-l-((phenyltlno)methyl)butyl)amino)-N- (2'-methoxy-4'-(3-(4- methylpiperazin-l-yl)propyP-l,r-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide Example 484A 2'-methoxy-4'-(3-(4-methylpiperazin- 1 -yppropyp- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 248A for Example 1 A in Example IB. Example 484B 4-r (lRV4-((Hmethylamino)-l-((phenylthio)methyl)butvPamino)-N-((2'-methoxy-4'-(3-(4- methylpiperazin- 1 -yPpropyP- 1 , 1 '-biphenyl-4-vP carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 484A and Example 489A for Example IB and Example IC, respectively, in Example ID. MS (ESI) m e 787, 789 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 1.53 (m, 4H), 1.75 (m, 2H), 2.18 (s, 3H), 2.26 (s, 6H), 2.38 (m, 4H), 2.60 (t, 2H), 2.98 (m, 8H), 3.74 (s, 3H), 4.02 (m, IH), 5.82 (m, 2H), 6.85 (d, IH), 6.93 (s, IH), 6.95 (d, IH), 7.17 (dd, 2H), 7.25 (td, 2H), 7.33 (dt, 2H), 7.38 (d, 2H), 7.82 (dd, IH), 7.88 (d, 2H), 8.15 (d, IH), 8.46 (d, IH). Example 485 N-(4-(4-ethyl-4-methoxypiperidin- 1 -yl)benzoyf)-3 -nitro-4-((2- (pheny lthio) ethyl) amino benzenesulfonamide Example 485A tert-butyl 4-ethyl-4-methoxypiperidine- 1 -carboxylate The desired product was prepared by substituting Example 495A for Example 494A in Example 494B. Example 485B 4-ethyl-4-methoxypiperidine The desired product was prepared by substituting Example 485A for Example 494B in Example 494C. Example 485C tert-butyl 4-(4-ethyl-4-methoxypiperidin- 1 -ypbenzoate The desired product was prepared by substituting Example 485B for Example 494C in Example 494D. Example 485D 4-(4-ethyl-4-methoxypiperidin- 1 -ypbenzoic acid The desired product was prepared by substituting Example 485C for Example 493A in Example 493B. Example 485E N-(4-(4-ethyl-4-methoxypiperidin-l-yl)benzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 48 ID and Example 77B for Example IB and Example IC, respectively, in Example ID. MS(ESI(+)) m/e 599 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 11.98 (s, IH), 8.78 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.73 (d, 2H), 7.37 (d, 2H), 7.28 (m, 2H), 7.18 (m, 2H), 6.93 (d, 2H), 3.65 (m, 4H), 3.28 (t, 2H), 3.07 (m, 5H), 1.75 ( , 2H), 1.43 (m, 4H), 0.77 (t, 3H). Example 486 N-(4-(4-(benzylsulfonyl)piperazin- 1 -yl)benzoyl)-3 -nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting benzylsulfonyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 694 (M-H) " ; l H NMR (500 MHz, DMSO-de) δ 12.06 (s, IH), 8.76 (t, IH), 8.60 (d, IH), 7.92 (dd, IH), 7.76 (d, 2H), 7.44-7.35 (m, 7H), 7.30-7.16 (m, 4H), 6.96 (d, 2H), 4.46 (s, 2H), 3.66 (q, 2H), 3.36-3.28 (m, 6H), 3.23-3.19 (m, 4H). Example 487 N-(4-(4-((4-methylphenyPsulfonvPpiperazin-l-yl)benzoyl)-3-nitro-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide The desired product was prepared by substituting p-toluenesulfonyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 694 (M-H) " ; l H NMR (500 MHz, DMSO-dg) δ 12.04 (s, IH), 8.77 (t, IH), 8.59 (d, IH), 7.90 (dd, IH), 7.72-7.63 (m, 2H), 7.64 (d, 2H), 7.45 (d, 2H), 7.36 (d, 2H), 7.26 (t, 2H), 7.18-7.14 (m, 2H), 6.91 (d, 2H), 3.66 (q, 2H), 3.42-3.39 (m, 4H), 3.28 (t, 2H), 2.97-2.94 (m, 4H), 2.39 (s, 3H). Example 488 N-(4-(4-benzylpiperidin- 1 -yl)benzoyP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide Example 488A tert-butyl 4-(4-benzylpiperidin- 1 -ypbenzoate The desired product was prepared by substituting 4-benzyl piperidine for 4-hydroxy- 4-phenyl piperidine in Example 493 A. Example 488B 4-(4-benzylpiperidin- 1 -ypbenzoic acid The desired product was prepared by substituting Example 488A for Example 493 A in Example 493B. Example 488C N-(4-(4-benzylpiperidin- 1 -yl)benzoyl)-3 -nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 488B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS(ESI(+)) m/e 631 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 11.98 (s, IH), 8.78 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.73 (d, 2H), 7.37 (d, 2H), 7.27 (m, 4H), 7.18 (m, 5H), 6.93 (d, 2H), 3.90 (2H, m), 3.66 (q, 2H), 3.28 (m, 2H), 2.78 (t, 2H), 2.53 (m, 2H), 1.77 (m, IH), 1.63 (m, 2H), 1.19 (m, 2H). Example 489 4-(((lR)-4-rdimethylamino)-l-((phenylthio)methyl)butyPamino)-N- (2'-methoxy-4'-(2-(4- methylpiperazin- 1 -yPethyP- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide Example 489A 4-(((lR)-4-(dimethylamino)-l-((phenylthio)methyl)butvPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 480D for Example 122F in Example 122G. MS (ESI) m/e 437, 439 (M-H) " , (M+H) + . Example 489B 4-(((lR)-4-(dimethylamino)-l-((phenylthio)methyl)butyPamino)-N-((2'-methoxy-4'-(2-(4- methylpiperazin- 1 -y ethyl)- 1 , 1 '-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 242B and Example 489A for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 773, 775 (M- H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.78 (m, 4H), 1.91 (m, 2H), 2.51 (m, 2H), 2.66 (s, 6H), 2.71 (m, 4H), 3.00 (m, 2H), 3.17 (s, 3H), 3.36 (m, 6H), 3.76 (s, 3H), 4.05 (m, IH), 6.90 (d, IH), 7.00 (m, 2H), 7.18 (m, IH), 7.22 (m, 3H), 7.31 (d, 2H), 7.39 (m, 2H), 7.83 (dd, IH), 7.90 (d, 2H), 8.15 (s, IH), 8.48 (d, IH). Example 490 3 -f 2-methoxy-4'-((((4-((( 1 R)-4-(4-methylpiperazin- 1 -vP- 1 - ((phenylthio)methvPbutyl)amino)-3-nitrophenyPsulfonyl)amino)carbonyP- 1 , 1 '-biphenyl-4- yP-N.N-curnethylpropanamide Example 490A tert-butyl ( lR)-4-(4-methylpiperazin- 1 -yl)-4-oxo- 1 -((phenylthio)methyPbutylcarbamate The desired product was prepared by substituting Example 480B and n- methylpiperazine for Example 122E and dimethylamine, respectively, in Example 122F. MS (ESI) m/e 406, 408 (M-H) " , (M+H) + . Example 490B 4-((( 1 R)-4-(4-methylpiperazin- 1 -yl)- 1 -((phenylthio)methyPbutyl) amino)-3 - nitrobenzenesulfonamide The desired product was prepared by substituting Example 490 A for Example 122F in Example 122G, then substituting the product obtained for Example 133A in Example 133B. MS (ESI) m/e 492, 494 (M-H) " , (M+H) + . Example 490C 3-(2-methoxy-4'-( ' ( ' (;(4-((flR)-4-(4-methylpiperazin-l-yP-l- ((phenylthio)methyl)butyPamino)-3-nitrophenyl)sulfonyl)amino)carbonyl)-l,r-biphenyl-4- yl)-N,N-dimethylpropanamide The desired product was prepared by substituting Example 482A and Example 490B for Example IB and Example IC, respectively, in Example ID. HNMR (300 MHz, DMSO-d 6 ) 6 1.78 (m, 4H), 2.52 (dd, 2H), 2.61 (m, 6H), 2.72 (s, 3H), 2.83 (s, 3H), 2.85 (m, 2H), 2.96 (s, 3H), 3.01 (m, 4H), 3.37 (m, 2H), 3.76 (s, 3H), 4.11 (m, IH), 6.91 (d, IH), 7.01 (s, IH), 7.09 (d, IH), 7.15 (d, IH), 7.20 (m, 3H), 7.30 (d, 2H), 7.46 (d, 2H), 7.90 (dd, IH), 7.93 (d, 2H), 8.21 (d, IH), 8.52 (d, IH). Example 491 tert-butyl 4-(2-(4'-((((4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyPpropyPamino)-3- nitrophenyPsulfonyl)amino)carbonvP-2-methoxy- 1 , 1 '-biphenyl-4-yPethyPpiperazine- 1 - carboxylate Example 491A 4-(2-hvdroxyethyl)-2-methoxyphenol The desired product was prepared by substituting homovanillyl alcohol for Example 201E in Example 201F. Example 491B methyl 4'-(2-hydroxyethyl)-2'-methoxy- 1 , 1 '-bipheny 1-4-carboxylate The desired product was prepared by substituting Example 491 A for Example 5A in Example 5B. Example 49 IC methyl 2'-methoxy-4'-(2-oxoethyl)- 1 , 1 '-biphenyl-4-carboxylate A solution of Example 491B (2.47 g, 8.63 mmol) in dichloromethane (25 mL) at room temperature was treated with Dess-Martin periodinane (4.03 g, 9.49 mmol), stirred for 90 minutes, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 1 : 1 ethyl acetate/hexanes to provide the desired product. Example 49 ID tert-butyl 4-(2-(2-methoxy-4'-(methoxycarbonyP- 1 , 1 '-biphenyl-4-yl)ethyl)piperazine- 1 - carboxylate A solution of Example 49 IC (400 mg, 1.41 mmol) and tert-butyl 1- piperazinecarboxylate (289 mg, 1.55 mmol) in 1,2-dichloroethane (5 mL) at room temperature was treated with sodium triacetoxyborohydride (329 mg, 1.55 mmol), and stirred for 16 hours. The solution was purified by flash column chromatography on sUica gel with 90: 10:0.25 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired product. Example 49 IE 4'-(2-(4-(tert-butoxycarbonyPpiperazin- 1 -yl) ethyl) -2'-methoxy- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 491D for Example 1 A in Example IB. Example 49 IF tert-butyl 4-(2-(4'-((((4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyPpropyPamino)-3- nitrophenyl)sulfonyl)amino)carbonyl)-2-methoxy- 1 , 1 '-biphenyl-4-yl)ethyl)piperazine-l - carboxylate The desired product was prepared by substituting Example 491E and Example 122G for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 845, 847 (M- H) " , (M+H) + ; a NMR (300 MHz, DMSO-d 6 ) δ 1.39 (s, 9H), 2.08 (m, 2H), 2.52 (s, 6H), 2.42 (m, 4H), 2.58 (m, 2H), 2.76 (m, 6H), 3.06 (m, 2H), 3.33 (t, 2H), 3.73 (s, 3H), 4.09 (m, IH), 6.88 (d, IH), 6.90 (d, IH), 6.98 (s, IH), 7.18 (dd, 2H), 7.26 (tt, 2H), 7.32 (dt, 2H), 7.38 (d, 2H), 7.82 (dd, IH), 7.88 (d, 2H), 8.23 (d, IH), 8.48 (d, IH). Example 492 4-(2-(4'-((((4-(((lR)-3-fdimethylamino)-l-((phenylthio)methvPpropyl)amino)-3- nitrophenyPsulfonyPamino)carbonyP-2-methoxy- 1. l i -biphenyl-4-yl)ethyl)piperazine- 1 - carboxamide A solution of Example 499 (40 mg, 0.05 mmol) in DMF (0.5 mL) at room temperature was treated with trimethylsilyl isocyanate (7 mg, 0.06 mmol), and stirred for 16 hours. The solution was purified by flash column chromatography on silica gel with 80:20:0.5 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired product. MS (ESI) m/e 788, 790 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 2.11 (m, 2H), 2.69 (s, 6H), 2.71 (m, 2H), 2.86 (m, 4H), 3.05 (m, 2H), 3.08 (m, 4H), 3.16 (d, 2H), 3.34 (t, 2H), 3.75 (s, 3H), 4.09 (m, IH), 6.13 (s, 2H), 6.88 (d, IH), 6.95 (d, IH), 7.00 (s, IH), 7.15-7.33 (m, 6H), 7.40 (d, 2H), 7.83 (dd, IH), 7.88 (d, 2H), 8.14 (d, IH), 8.48 (d, IH). Example 493 4-((( 1 R)-5-(dimethylamino)- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(4-hvdroxy-4- phenylpiperidin-l-yPbenzoyP-3-nitrobenzenesulfonamide Example 493A tert-butyl 4-(4-hydroxy-4-phenylpiperidin- 1 -ypbenzoate A solution of 4-hydroxy-4-phenyl piperidine (221mg, 1.25mmol) in DMSO (1 mL) was treated with tert-butyl-4-fluorobenzoate (196 mg, 1.00 mmol) and powdered potassium carbonate (173 mg, 1.25 mmol), stirred vigorously at 125 °C for 16 hours, cooled to room temperature, dUuted with diethyl ether, washed with brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (DCI(+)) m/e 354 (M+H) . Example 493B 4~(4-hydroxy-4-phenylpiperidin- 1 -yPbenzoic acid A solution of Example 493A (0.32 g, 0.91 mmol) in TFA (2 mL) at room temperature was stirred for 1 hour, and concentrated. The concentrate was azeotropically distUled with toluene three times and dried to provide the desired product. MS (ESI(+)) m/e 298 (M+H) . Example 493 C 4-(((lR)-5-(dimethylamino)-l-((phenyltMo)methyl)pentyPamino)-N-(4-(4-hydroxy-4- phenylpiperidin- 1 -yPbenzoyl)-3 -nitrobenzenesulfonamide The desired product was prepared by substituting Example 124E and Example 493B for Example IC and Example IB, respectively, in Example ID. MS(ESI(+)) m/e 732 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 8.45 (d, IH), 8.15 (d, IH), 7.84 (dd, IH), 7.75 (d, 2H), 7.45 (d, 2H), 7.30 (m, 4H), 7.20 (m, 4H), 6.95 (d, IH), 6.87 (d, 2H), 5.00 (s, IH), 4.02 (m, IH), 3.65 ( , 2H), 3.18 (m, 2H), 2.90 (m, 2H), 2.67 (s, 6H), 2.00 (m, 2H), 1.85-1.50 (m, 6H), 1.35 (m, 2H). Example 494 4-((( 1 R)-5-(dimethylamino)- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(4-methoxy-4- methylpiperimn-l-yPbenzoyl)-3-nitrobenzenesulfonamide Example 494A tert-butyl 4-hydroxy-4-methylpiperidine- 1 -carboxylate A solution of 3M methyl magnesium bromide in diethyl ether (2.0 mL) in diethyl ether (3 mL) at 0 °C was treated with a solution of tert-butyl 4-oxo-l-piperidinecarboxylate (1.0 g, 5.00 mmol) in diethyl ether (5 mL), warmed to room temperature, stirred for 18 hours, treated with saturated NH 4 CI, and extracted with diethyl ether. The combined extracts were washed with brine, dried (MgSO 4 ), filtered, and concentrated. The concentratet was purified by flash chromatography on sUica gel with 20%-50% ethyl acetate/heptane to provide the desired product. MS (DCI(+)) m/e 216 (M+H) + . Example 494B tert-butyl 4-methoxy-4-methylpiperidine- 1 -carboxylate A suspension of 60% NaH in mineral oU (160 mg, 4 mmol) in THF (5 mL) at room temperature was treated with a solution of Example 494A (430 mg, 2.00 mmol) in THF (5 mL), heated to 55 °C for 2 hours, cooled to room temperature, treated with HMPA (2.5 mL) and methyl iodide (0.50 mL), heated to 55 °C for 16 hours, cooled to room temperature, quenched with 10% aqueous citric acid, and extracted twice with diethyl ether. The combined extracts were washed sequentially with water, saturated NaHCO 3 , and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10%-20% ethyl acetate/heptane to provide the desired product. Example 494C 4-methoxy-4-methylpiperidine A solution of Example 494B (115 mg, 0.5 mmol) in TFA (1 mL) at room temperature was stirred for 1.5 hours and concentrated. The product was azeotropically distilled with toluene three times and concentrated to provide the desired product as the trifluoroacetate salt. Example 494D tert-butyl 4-(4-methoxy-4-methylpiperidin- 1 -ypbenzoate A solution of Example 494C (0.5 mmol) in DMSO (0.5 mL) at room temperature was treated with tert-butyl-4-fluorobenzoate (118 mg, 0.60 mmol) and powdered potassium carbonate (207 mg, 1.5 mmol), heated to 125 °C for 16 hours, and cooled to room temperature. The mixture was dUuted with ethyl acetate, washed with brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 10%-30% ethyl acetate/hexanes to provide the desired product. MS (DCI(+)) m/e 306 (M+H) + . Example 494E 4-(4-methoxy-4-methylpiperidin- 1 -ypbenzoic acid The desired product was prepared by substituting Example 494D for Example 493A in Example 493B. Example 494F 4-(((lR)-5-(dimethylamino)-l-((phenylthio)methyl)pentyl)amino)-N-(4-(4-methoxy-4- methylpiperidin- 1 -yPbenzoyP-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 494E and Example 124E for Example IB and Example IC, respectively, in Example ID. MS(ESI(+)) m/e 684 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 8.45 (d, IH), 8.15 (d, IH), 7.82 (dd, IH), 7.73 (d, 2H), 7.30 (d, 2H), 7.25 (t, 2H), 7.15 (m, IH), 6.95 (d, IH), 6.80 (d, 2H), 4.02 (m, IH), 3.35 (m, 2H), 3.10 (s, 3H), 3.05 (m, 2H), 2.90 (m, 2H), 2.68 (s, 6H), 1.75 (m, 4H), 1.55 (m, 4H), 1.30 (m, 4H), 1.10 (s, 3H). Example 495 4-((( 1 R)-5-(dimethylamino)- 1 -((phenylthio)methyl)pentyl)amino)-N-(4-(4-ethyl-4- hydroxypiperidin-l-yPbenzoyl)-3-nitrobenzenesulfonamide Example 495A tert-butyl 4-ethyl-4-hydroxypiperidine- 1 -carboxylate The desired product was prepared by substituting ethyl magnesium bromide for methyl magnesium bromide in Example 494A. Example 495B 4-ethylpiperidin-4-ol The desired product was prepared by substituting Example 495A for Example 492B in Example 492C. Example 495C tert-butyl 4-(4-ethyl-4-hydroxypiperidin- 1 -ypbenzoate The desired product was prepared by substituting Example 495B for Example 494C in Example 494D. Example 495D 4-(4-ethyl-4-hydroxypiperidin- 1 -ypbenzoie acid The desired product was prepared by substituting Example 495C for Example 493A in Example 493B. Example 495E 4-(((lR)-5-(dimethylamino)-l-((phenylthio)methyl)pentyl)amino)-N-(4-(4-ethyl-4- hydroxypiperidin-l-yl)benzoyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 495D and Example 124E for Example IB and Example IC, respectively, in Example ID. MS ESI(+)) m/e 684 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 11.95 (s, IH), 9.25 (s, IH), 8.55 (d, IH), 8.31 (d, IH), 7.88 (dd, IH), 7.72 (d, 2H), 7.25-7.05 (m, 5H), 6.93 (d, 2H), 4.10 (m, IH), 3.60 (m, 2H), 3.35 (m, 2H), 3.20 (m, 2H), 2.95 (m, 2H), 2.70 (d, 6H), 1.75 (m, 2H), 1.55 (m, 2H), 1.50-1.30 (m, 8H), 0.80 (t, 3H). Example 496 N-(4-(4-benzyl-4-hydroxypiperidin- 1 -yPbenzoyP-4-((( lR)-5-(dimethylamino)- 1 - ((phenylthio)methyl)pentyl)amino -3-nitrobenzenesulfonamide Example 496A tert-butyl 4-(4-benzyl-4~hydroxypiperidin- 1 -ypbenzoate The desired product was prepared by substituting 4-hydroxy-4-benzyl piperidine for 4-hydroxy-4-phenyl piperidine in Example 493 A. Example 496B 4-(4-benzyl-4-hydroxypiperidin- 1 -ypbenzoie acid The desired product was prepared by substituting Example 496A for Example 493 A in Example 493B. Example 496C N-(4-(4-benzyl-4-hydroxypiperidin- 1 -yl)benzoyl)-4-((( 1 R)-5-(dimethylamino)- 1 - ((phenyltMo)mLethyPpentyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 124E and Example 496B for Example IC and Example IB, respectively, in Example ID. MS (ESI(+)) m/e 746 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 8.45 (d, IH), 8.15 (d, IH), 7.80 (dd, IH), 7.70 (d, 2H), 7.35-7.15 (m, 10H), 6.95 (d, IH), 6.80 (d, 2H), 4.30 (s, IH), 4.02 (s, IH), 3.45 (m, 2H), 3.05 (m, 2H), 2.90 (m, 2H), 2.70 (s, 2H), 2.65 (s, 6H), 1.75 (m, 2H), 1.55 (m, 4H), 1.50-1.20 ( , 4H). Example 497 N~2~-((4'-((((4-((( lR)-4-f dimethylamino)- 1 -((phenylthio)methyl)butvPamino)-3- nitrophenyPsulfonyPamino)carbonyl)-2-methoxy- 1 , 1 '-bipheny 1-4-yPmethyl)- N~1~,N~1~,N~2 — trimethylglycinamide Example 497A methyl 4'-(((2-(dimethylamino)-2-oxoethyl)(methyl)amino)methyP-2'-methoxy- 1.1'- biphenyl-4-carboxylate The desired product was prepared by substituting Example 1221 and sarcosine dimethylamide for Example 49 IC and tert-butyl 1-piperazinecarboxylate, respectively, in Example 49 ID. Example 497B 4'-(((2-(dimethylamino)-2-oxoethyl)(methyl)amino)methvP-2'-methoxy-l , 1 '-biphenyl-4- carboxylic acid The desired product was prepared by substituting Example 497A for Example 1 A in Example IB. Example 497C N~2~-((4'-((((4-(((lR)-4-(dimethylamino)-l-((phenylthio)methvPbutyl)amino)-3- nitrophenyPsulfonyl)amino)carbonyP-2-methoxy- 1 , 1 '-biphenyl-4-yl)methyP- N~l~.N~l~,N~2~-trimethylglycinamide The desired product was prepared by substituting Example 497B and Example 489A for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 775, 777 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 1.55 (m, 4H), 1.75 (m, 2H), 2.20 (s, 3H), 2.32 (s, 6H), 2.45 (t, 2H), 2.81 (s, 3H), 3.02 (s, 3H), 3.23 (s, 2H), 3.58 (s, 2H), 3.74 (s, 3H), 4.02 (m, IH), 6.95 (d, 2H), 7.04 (s, IH), 7.18 (dt, IH), 7.24 (m, 2H), 7.31 (m, 2H), 7.40 (d, 2H), 7.83 (dd, IH), 7.89 (d, 2H), 8.11 (d, 2H), 8.47 (d, IH). Example 498A methyl 4'-(((2-(dimethylamino)-2-oxoethyl)(methyl)amino)ethyl)-2'-methoxy- 1 , 1 '-biphenyl- 4-carboxylate The desired product was prepared by substituting sarcosine dimethylamide for tert- butyl 1-piperazincarboxylate in Example 49 ID. Example 498B 4'-(((2-(dimethylamino)-2-oxoethyP(methyPamino)ethyl)-2'-methoxy-l , 1 '-biphenyl-4- carboxylic acid The desired product was prepared by substituting Example 498A for Example 1 A in Example IB. Example 498C , N~2~-(2-(4'-((((4-(((lR)-4-(dimethylamino)-l-((phenylthio methyPbutyl)amino)-3- nitrophenyl)sulfonyl)amino)carbonyl)-2-methoxy- 1 , 1 '-biphenyι-4-yPethyP- N~ 1 ~,N~ 1 ~,N~2 — trimethylglycinamide The desired product was prepared by substituting Example 498B and Example 489A for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 789, 791 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 1.65 (m, 4H), 1.75 (m, 2H), 2.35 (s, 3H), 2.57 (s, 6H), 2.78 (s, 3H), 2.81 (m, 6H), 2.91 (s, 3H), 3.35 (s, 2H), 3.74 (s, 3H), 4.04 (m, IH), 6.86 (d, IH), 6.96 (m, 2H), 7.18 (m, 2H), 7.25 (t, 2H), 7.32 (m, 2H), 7.38 (d, 2H), 7.83 (dd, IH), 7.88 (d, 2H), 8.14 (d, IH), 8.47 (d, IH). Example 499 4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyl)propyl)amino)-N-((2'-methoxy-4'-(2- piperazin- 1 -ylethyP- 1 , 1 '-biphenyl-4-yl)carbonyP-3-nitrobenzenesulfonamide A solution of Example 491F (284 mg, 0.34 mmol) in 1,4-dioxane (1.5 mL) and 4M HCl (1.5 mL) at room temperature was stirred for 16 hours. The solution was purified by flash column chromatography on sUica gel with 80:20:0.5 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired product. MS (ESI) m/e 745, 747 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-de) δ 2.11 (m, 2H), 2.62 (s, 6H), 2.67 (m, 4H), 2.77 (m, 2H), 3.00 (m, 2H), 3.06 (m, 4H), 3.16 (d, 2H), 3.33 (t, 2H), 3.75 (s, 3H), 4.09 (m, IH), 6.88 (d, IH), 6.95 (d, IH), 6.98 (s, IH), 7.15-7.22 (m, 2H), 7.24-7.33 (m, 4H), 7.38 (d, 2H), 7.82 (dd, 1H), 7.88 (d, 2H), 8.17 (d, 1H), 8.47 (d, IH). Example 500 tert-butyl 4-((4'-((((4-(((lR)-3-(dimethylamino)-l-((phenyltMo)methyl)propyl)amino)-3- nitrophenyl)sulfonyl)amino)carbonyP-2-methoxy- 1 , 1 '-bipheny 1-4-yPmethyP -3- oxopiperazine- 1 -carboxylate Example 500A piper azin-2-one A solution of ethylenediamine (66.40 g, 1106 mmol) in ethanol (300 mL) at room temperature was treated dropwise with a solution of ethyl chloroacetate (20.00 g, 184 mmol) in ethanol (100 mL) over 3 hours, stirred for 2 hours, treated with sodium ethoxide (13.13 g, 193 mmol), and filtered. The filtrate was concentrated, dissolved in DMF (200 mL), stirred for 16 hours, heated to 65 °C for 72 hours, cooled to room temperature, and concentrated. The concentrate was purified by flash column chromatography on sUica gel with 80:20:0.5 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired product. Example 500B tert-butyl 3-oxopiperazine- 1 -carboxylate A solution of Example 500A (500 mg, 4.99 mmol) in acetonitrUe (25 mL) at room temperature was treated with BOC 2 O (1198 mg, 5.49 mmol), stirred for 3 hours, and , concentrated. The concentrate was purified by flash column chromatography on silica gel with 95: 5 ethyl acetate/methanol to provide the desired product. Example 500C methyl 4'-(bromomethyl)-2'-methoxy- 1 , 1 '-biphenyl-4-carboxylate A solution of Example 417A (1.50 g, 5.51 mmol) in DMF (18.0 mL) at 0 °C was treated with LiBr (526 mg, 6.06 mmol) and PBr 3 (1.64 g, 6.06 mmol), warmed to room temperature, and stirred for 30 minutes. The solution was purified by flash column chromatography on silica gel with 3:7 ethyl acetate/hexanes to provide the desired product. Example 500D tert-butyl 4-((2-methoxy-4'-(methoxycarbonyl)- 1 , 1 '-biphenyl-4-yl)methyl)-3-oxopiperazine- 1 -carboxylate A solution of Example 500B (328 mg, 1.64 mmol) in DMF (4 mL) at room temperature was treated with 15-crown-5 (361 mg, 1.64 mmol) and 60 % sodium hydride in mineral oU (66 mg, 1.64 mmol). The mixture was treated with a solution of Example 500C (500 mg, 1.49 mmol) in DMF (2 mL), heated to 60 °C for 16 hours, cooled to room temperature, treated with water (20 mL), and extracted three times with ethyl acetate (50 mL). The combined extracts were washed with brine (10 mL), dried (Na 2 SO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 1 : 1 ethyl acetate/hexanes to provide the desired product. Example 500E 4'-((4-(tert-butoxycarbonyl)-2-oxopiperazin- 1 -yPmethyl)-2'-methoxy- 1.1 '-biphenyl-4- carboxylic acid The desired product was prepared by substituting Example 500D for Example 1 A in Example IB. Example 500F tert-butyl 4-((4'-((((4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyl)propyl)amino)-3- nitrophenyPsulfonyl)amino)carbonyP-2-methoxy- 1 , 1 '-biphenyl-4-yl)methyP-3- oxopiperazine- 1 -carboxylate The desired product was prepared by substituting Example 500E and Example 122G for Example IB and Example IC, respectively, in Example ID. MS (ESI) m/e 845, 847 (M- H) " , (M+H) + ; NMR (300 MHz, DMSO-d 6 ) δ. 1.41 (s, 9H), 2.01 (m, 2H), 2.33 (s, 6H), 2.65 (m, 2H), 3.27 (d, 2H), 3.32 (t, 2H), 3.56 (t, 2H), 3.74 (s, 3H), 4.01 (s, 2H), 4.09 (m, IH), 4.57 (s, 2H), 6.88 (m, 2H), 6.98 (s, IH), 7.18 (dt, IH), 7.26 (m, 3H), 7.32 (m, 2H), 7.39 (d, 2H), 7.81 (dd, IH), 7.88 (d, 2H), 8.34 (d, IH), 8.47 (d, IH). Example 501 4-(((lR)-3-(dimethylammo)-l-((phenylthio)methyl)piOpyPamino)-N-((2'-methoxy-4'-((2- oxopiperazin-l-ypmethyl)-l,r-biphenyl-4-yl)carbonyp-3-nitrobenzenesulfonamide A solution of Example 500F (73 mg, 0.09 mmol) in dioxane (1 mL) and 4M HCl (1 mL) at room temperature was stirred for 16 hours, and purified by flash column chromatography on silica gel with 80:20:0.5 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired product. MS (ESI) m/e 745, 747 (M-H) " , (M+H) + ; X H NMR (300 MHz, DMSO-d 6 ) δ 2.07 (m, 2H), 2.54 (d, 6H), 2.74 (m, IH), 3.04 (m, 2H), 3.17 (d, 2H), 3.23 (t, 2H), 3.32 (t, 2H), 3.47 (s, 2H), 3.74 (s, 3H), 4.09 (m, IH), 4.54 (s, 2H), 6.89-6.99 (m, 3H), 7.17 (tt, 2H), 7.22-7.34 (m, 4H), 7.39 (d, 2H), 7.81 (dd, IH), 7.88 (dd, 2H), 8.21 (d, IH), 8.47 (d, IH). Example 502 N-(4-(4-(4-methoxybenzoyl)piperazin- 1 -yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting 4-methoxybenzoyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 674 (M-H) " ; H NMR (500 MHz, DMSO-de) δ 12.02 (s, IH), 8.76 (t, IH), 8.61 (d, IH), 7.92 (dd, IH), 7.77 (d, 2H), 7.41 (d, 2H), 7.37 (d, 2H), 7.26 (t, 2H), 7.15-7.20 (m, 2H), 6.99 (d, 2H), 6.95 (d, 2H), 3.80 (s, 3H), 3.67 (q, 2H), 3.61 (br s, 4H), 3.39 (br s, 4H), 3.28 (t, 2H). Example 503 N-(4-(4-((3-fluorophenyl)sulfonyl)piperazin-l-yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting 3-fluorobenzenesulfonyl chloride for 2-methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 698 (M-H) " ; 1H NMR (500 MHz, DMSO-de) 12.04 (s, IH),, 8.77 (t, IH), 8.59 (d, IH), 7.89 (dd, IH), 7.69-7.75 (m, 3H), 7.58-7.63 (m, 3H), 7.36 (d, 2H), 7.26 (t, 2H), 7.14-7.20 (m, 2H), 6.92 (d, 2H), 3.66 (q, 2H), 3.40-3.44 (m, 4H), 3.28 (t, 2H), 3.01-3.05 (m, 4H). Example 504 N-(4-(4-((4-fluorophenvPsulfonyPpiperazin-l-yl)benzovP-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting 4-fluorobenzenesulfonyl chloride for 2-methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 698 (M-H) " ; 1H NMR (500 MHz, DMSO-d 6 ) δ 12.04 (s, IH), 8.77 (t, IH), 8.59 (d, IH), 7.90 (dd, IH), 7.86-7.82 (m, 2H), 7.73 (d, 2H), 7.49 (t, 2H), 7.36 (d, 2H), 7.26 (t, 2H), 7.20-7.14 (m, 2H), 6.91 (d, 2H), 3.66 (q, 2H), 3.44-3.40 (m, 4H), 3.28 (t, 2H), 3.01-2.98 (m, 4H). Example 505 3-nitro-4-((2-(phenylthio)ethyl)amino)-N-(4-(4-((4-propylphenyPsulfonyl)piperazin-l- ypbenzoypbenzenesulfonamide The desired product was prepared by substituting 4-propylbenzenesulfonyl chloride for 2-methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 722 (M-H) " ; 1HNMR (500 MHz, DMSO-de) δ 12.01 (s, IH),. 8.75 (t, IH), 8.58 (d, IH), 7.89 (dd, IH), 7.72 (d, 2H), 7.66 (d, 2H), 7.46 (d, 2H), 7.36 (d, 2H), 7.26 (t, 2H), 7.14-7.20 (m, 2H), 6.90 (d, 2H), 3.66 (q, 2H), 3.42-3.39 (m, 4H), 3.28 (t, 2H), 2.99-2.95 (m, 4H), 2.64 (t, 2H), 1.60 (hextet, 2H), 0.86 (t, 3H). Example 506 N-(4-(8-azaspiro(4.5)dec-8-yPbenzoyP-3-nitro-4-((4-((phenylthio)methyl)piperidin-4- yl) amino)benzenesulfonamide The desired product was prepared by substituting Example 472C and Example 257C for Example IC and Example IB, respectively, in Example ID. The crude product was purified by reverse-phase chromatography using a C-18 column and 50% CHsCN/water containing 0.01M HCl to provide the desired product as the hydrochloride salt. MS (ESI) m/e 662, 664 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1,42 (m, 8H), 1.59 (m, 4H), 2.05 (m, 2H), 3.02 (m, 2H), 3.21 (m, 2H), 3.35 (m, 4H), 3.63 (m, 4H), 6.86 (m, 3H), 6.96 (d, 2H), 7.21 (d, 2H), 7.33 (d, IH), 7.79 (m, 3H), 8.29 (d, IH), 8.46 (d, IH), 9.02 (br s, 2H). Example 507 (4R)-4-((4-(((4-(8---zaspiro(4.5)dec-8-yPbenzoyPamino)sulfonyl)-2-nitrophenyl)amino)- N,N-dimethyl-5-(phenylthio)pentanamide The desired product was prepared by substituting Example 480D and Example 257C for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 692, 694 (M- H) " , (M+H) + ; ! H NMR (300 MHz, DMSO-d 6 ) δ 1.41 (m, 4H), 1.48 (m, 4H), 1.59 (m, 4H), 1.93 (m, 2H), 2.38 (m, 2H), 2.75 (s, 3H), 2.83 (s, 3H), 3.19 (m, 4H), 3.32 (m, 3H), 4.04 (m, IH), 6.80 (d, 2H), 6.91 (d, IH), 7.15 (dd, IH), 7.22 (dd, 2H), 7.31 (d, 2H), 7.72 (d, 2H), 7.79 (dd, IH), 8.12 (d, IH), 8.42 (d, IH). Example 508 N-(4-(8-azaspiro 4.5)dec-8-yl)benzovP-4-((πR)-4-(dimethylamino)-l- ((phenyltMo)methyl)butyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 489A and Example 257C for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 678 (M-H) " ; 1H NMR (300 MHz, DMSO-de) δ 1.41 (m, 4H), 1.48 (m, 4H), 1.59 (m, 4H), 1.85 (m, 2H), 2.41 (s, 6H), 2.62 (m, 2H), 2.66 (m, 2H), 3.19 (M, 4H), 3.31 (ddd, 2H), 4.02 (m, IH), 6.80 (d, 2H), 6.93 (d, IH), 7.16 (dd, IH), 7.22 (dd, 2H), 7.31 (d, 2H), 7.73 (d, 2H), 7.81 (dd, IH), 8.12 (d, IH), 8.46 (d, IH). Example 509 4-(((lR)-4-(dimethylamino)-l-((phenylthio)methyl)butyl)amino)-N-((2'-methoxy-4'-(3- moφhoHn-4-ylpropyl)-l , 1 '-biphenyl-4- yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 489A and Example 1220 for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 774, 776 (M- H) " , (M+H) + ; *H NMR (300 MHz, DMSO-d 6 ) δ 1.77 (m, 4H), 2.05 (m, 2H), 2.68 (s, 6H), 2.96-3.05 (m, 9H), 3.37 (m, 4H), 3.77 (s, 3H), 3.84 (m, 4H), 4.08 (m, IH), 6.90 (d, IH), 6.99 (s, IH), 7.03 (d, IH), 7.16 (dd, IH), 7.21 (s, IH), 7.23 (dd, 2H), 7.30 (d, 2H), 7.42 (d, 2H), 7.85 (dd, 2H), 7.91 (d, 2H), 8.15 (d, IH), 8.50 (d, IH). Example 510 N-(4-(8-azaspiro(4.5)dec-8-vPbenzoyP-4-(((lR)-3-(4-methylpiperazin-l-yl)-l- ((phenyltMo)methyl)propyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 481 A and Example 257C for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 719, 721 (M- H) " , (M+H) + ; a NMR (300 MHz, DMSO-d 6 ) δ 1.41 (m, 4H), 1.48 (m, 4H), 1.59 (m, 4H), 1.72 (m, 4H), 1.82 (m, 2H), 2.41 (s, 3H), 2.91 (m, 2H), 3.01 (m, 2H), 3.05 (m, 2H), 3.19 (m, 4H), 3.36 (m, 2H), 4.09 (m, IH), 6.80 (d, 2H), 6.95 (d, IH), 7.17 (dd, IH), 7.22 (dd, 2H), 7.31 (d, 2H), 7.74 (d, 2H), 7.81 (dd, IH), 8.23 (d, IH), 8.46 (d, IH). Example 511 N-((4'-(3-hvdroxypropyl)-2 , -methoxy-l,l'-biphenyl-4-yl)carbonyl)-4-(((lR)-3-(4- methylpiperazin-l-yp-l-((phenyltMo)methvPpropyPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 481 A and Example 45 IB for Example IC and Example IB, respectively, in Example ID. The product was dissolved in TFA (5 mL) and stirred at room temperature for 90 minutes, concentrated, dissolved in toluene, and concentrated again to provide the desired product MS (ESI) m/e 746, 748 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 1.77 (m, 4H), 2.63 (m, 2H), 2.66 (s, 6H), 3.00 (m, 6H), 3.04 (m, 4H), 3.37 (m, 2H), 3.42 (m, 2H), 3.84 (m, 4H), 4.15 (m, 2H), 6.85 (d, IH), 6.93 (s, IH), 7.03 (d, IH), 7.16 (dd, IH), 7.21 (s, IH), 7.23 (dd, 2H), 7.30 (d, 2H), 7.44 (d, 2H), 7.88 (dd, 2H), 7.91 (d, 2H), 8.25 (d, IH), 8.51 (d, IH). Example 512 N-((2'-methoxy-4'-(3-moφhohn-4-ylpropyP- 1 , 1 '-biphenyl-4-yl)carbonyl)-4-((( 1 R)-4-(4- methylpiperazin- 1 -yl)- 1 -((phenyltMo)methyl)butyl)amino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 490B and Example 1220 for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 829, 831 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-de) δ 1.59 (m, 2H), 1.79 ( , 4H), 2.22 (dd, 2H), 2.29 (m, 4H), 2.34 (m, 2H), 2.52 (m, 2H), 2.62 (m, 2H), 3.01 (m, 6H), 3.02 (s, 3H), 3.14 (m, IH), 3.32 (m, 2H), 3.59 (m, 4H), 3.76 (s, 3H), 4.00 (m, IH), 6.85 (d, IH), 6.93 (s, IH), 6.96 (d, IH), 7.18 (dd, IH), 7.19 (s, IH), 7.23 (dd, 2H), 7.31 (d, 2H), 7.40 (d, 2H), 7.85 (dd, IH), 7.91 (d, 2H), 8.17 (d, IH), 8.49 (d, IH). Example 513 N-(4-(8-azaspiro(4.5)dec-8-yl)benzoyl)-4-((( 1 R)-4-(4-methylpiperazin- 1 -yl)- 1 - ((phenyltMo)methyl)butyPamino)-3-nitrobenzenesulfonarnide The desired product was prepared by substituting Example 490B and Example 257C for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 733, 735 (M- H) " , (M+H) + ; ai NMR (300 MHz, DMSO-d 6 ) δ 1.41 (m, 4H), 1.48 (m, 4H), 1.59 (m, 4H), 1.72 (m, 4H), 1.82 (m, 2H), 2.33 (s, 3H), 2.48 (m, 2H), 2.59 (s, 4H), 2.82 (m, 4H), 3.19 (m, 4H), 3.31 (m, 2H), 4.00 (m, IH), 6.80 (d, 2H), 6.95 (d, IH), 7.17 (dd, IH), 7.22 (dd, 2H), 7.31 (d, 2H), 7.74 (d, 2H), 7.81 (dd, IH), 8.15 (d, IH), 8.43 (d, IH). Example 514 N-((4'-(2-((2-(dimethylamino)ethyl)(methyPamino)ethyl)-2'-methoxy- 1 , 1 '-biphenyl-4- yl)carbonyl)-4-(((lR)-3-(dimethylamino)-l-((phenylthio)methyl)propyl)amino)-3- nitrobenzenesulfonamide The desired product was prepared by substituting Example 122G and Example 191 C for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 747, 749 (M- H) (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 1.75 (m, 4H), 2.20 (m, 2H), 2.66 (s, 6H), 2.70 (s, 6H), 2.96-3.04 (m, 8H), 3.36 (m, 2H), 3.78 (s, 3H), 4.18 (m, IH), 6.97 (d, IH), 7.01 (s, IH), 7.04 (d, IH), 7.18 (dd, IH), 7.21 (s, IH), 7.25 (dd, 2H), 7.31 (d, 2H), 7.43 (d, 2H), 7.84 (dd, IH), 7.91 (d, 2H), 8.15 (d, IH), 8.49 (d, IH). Example 515 4-((( 1 R)-3-(dimethylamino)- 1 -((phenylthio)methyl)propyPamino)-N-((2'-methoxy-4'-(2-(4- methylpiperazin-1 -y ethyp- 1 , 1 '-biphenyl-4-yPcarbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 122G and Example 242B for Example IC and Example IB, respectively, in Example ID. MS (ESI) m/e 759, 761 (M- H) " , (M+H) + ; H NMR (300 MHz, DMSO-d 6 ) δ 2.20 (m, 2H), 2.48 (s, 3H), 2.68 (s, 6H), 2.72 (m, 2H), 2.97-3.05 (m, 4H), 3.14 (s, 2H), 3.17 (m, 2H), 3.36 (m, 6H), 3.76 (s, 3H), 4.18 (m, IH), 6.91 (d, IH), 7.01 (s, IH), 7.04 (d, IH), 7.18 (dd, IH), 7.21 (s, IH), 7.23 (dd, 2H), 7.31 (d, 2H), 7.41 (d, 2H), 7.83 (dd, IH), 7.90 (d, 2H), 8.14 (d, IH), 8.49 (d, IH). Example 516 4-((( lR)-4-(dimethylamino)- 1 -((phenylthio)methyl)butyPamino)-N-((2'-methoxy-4'-((4- methylpiperazin- 1 -vPmethyP- 1 , 1 '-biphenyl-4-yl)carbonvP-3-nitrobenzenesulfonamide Example 516A methyl 2'-methoxy-4'-((4-methylpiperazin-l-yl)methyl)-l,r-biphenyl-4-carboxylate The desired product was prepared by substituting Example 1221 andN- methylpiperazine for Example 134A and dimethylamine, respectively, in Example 134B. Example 516B 2'-methoxy-4 '-((4-methylpiperazin- 1 -yPmethyP- 1 , 1 '-biphenyl-4-carboxylic acid The desired product was prepared by substituting Example 516A for Example 1A in Example IB. Example 516C 4-((( 1 R)-4-(dimethylamino)- 1 -((phenylthio)methyl)butyPamino)-N-((2'-methoxy-4'-((4- methylpiperazin-l-yl)methyl)-l,r-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 489A and Example 516B for Example IC and Example IB, respectively, in Example ID. MS (ESI) m e 761 (M+H) ; 1H NMR (300 MHz, DMSO-de) δ 1.78 (m, 4H), 2.66 (s, 9H), 2.70 (m, 2H), 3.00 (m, 2H), 3.14 (s, 2H), 3.35 (m, 6H), 3.61 (m, 2H), 3.76 (s, 3H), 4.06 (m, IH), 6.97 (d, IH), 7.00 (s, IH), 7.02 (d, IH), 7.16 (dd, IH), 7.22 (s, IH), 7.24 (dd, 2H), 7.31 (d, 2H), 7.41 (d, 2H), 7.85 (dd, IH), 7.90 (d, 2H), 8.14 (d, IH), 8.49 (d, IH). Example 517 N-((2'-methoxy-4'-(2-(4-methylpiperazin- 1 -ypethyl)- 1 , 1 '-biphenyl-4-ypcarbonyP-4-((( 1 R)-4- (4-methylpiperazin-l-yl)-l-((phenyltMo)methyl)butvPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 490B and Example 242B for Example IC and Example IB, respectively, Example ID. MS (ESI) m/e 828, 830 (M-H) " , (M+H) + ; 1H NMR (300 MHz, DMSO-d 6 ) δ 1.57 (m, 2H), 1.77 (m, 2H), 2.46 (m, 2H), 2.50- 2.63 (m, lOH), 2.82 (m, 4H), 2.91 (m, 4H), 3.02 (m, 6H), 3.27 (m, 2H), 3.37 (m, 2H), 3.76 (s, 3H), 4.18 (m, IH), 6.90 (d, IH), 6.96 (d, IH), 7.01 (s, IH), 7.18 (dd, IH), 7.20 (s, IH), 7.22 (dd, 2H), 7.31 (d, 2H), 7.40 (d, 2H), 7.84 (dd, IH), 7.91 (d, 2H), 8.15 (d, IH), 8.48 (d, IH). Example 518 3-nitro-N-(4-(l-oxa-9-azaspiro(5.5)undec-3-en-9-yl)benzoyP-4-((2- (phenylthio) ethyl) amino)benzenesulfonamide Example 518A tert-butyl 4-aUyl-4-hydroxypiperidine- 1 -carboxylate The desired product was prepared by substituting allyl magnesium bromide for methyl magnesium bromide in Example 494A. MS (DCI(+)) m/e 242 (M+H) + . Example 518B tert-butyl 4-aUyl-4-(aUyloxy)piperidine- 1 -carboxylate The title compound was prepared by substituting Example 518A and allyl bromide for Example 494A and methyl iodide, respectively, in Example 494B. MS (DCI(+)) m/e 282 (M+H) + . Example 518C tert-butyl l-oxa-9-azaspiro(5.5)undec-3-ene-9-carboxylate A solution of Example 518B (0.79 g, 2.81 mmol) in degassed benzene (100 mL) at room temperature was treated with bis-tricyclohexylphosphine benzylidene ruthenium (IV) dichloride (150 mg), stirred for 18 hours, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 10%-25% ethyl acetate/heptane to provide the desired product. MS (DCI(+)) m/e 254 (M+H) + . Example 518D 1 -oxa-9-azaspiro(5.5)undec-3-ene The desired product was prepared by substituting Example 518C for Example 494B in Example 494C. Example 518E tert-butyl 4-(l -oxa-9-azaspiro(5.5)undec-3-en-9-yl)benzoate The desired product was prepared by substituting Example 518D for Example 494C in Example 494D. MS (DCI(+)) m/e 330 (M+H) + . Example 518F 4-(l-oxa-9-azaspiro(5.5)undec-3-en-9-yPbenzoic acid The desired product was prepared by substituting Example 518F for Example 493A in Example 493B. MS (DCI(+)) m/e 274 (M+H) + . Example 518G 3-nitro-N-(4-( 1 -oxa-9-azaspiro(5.5)ιmdec-3-en-9-yl)benzoyl)-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting Example 518F and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 609 (M+H) + ; *H NMR (500 MHz, DMSO-d 6 ) δ 11.95 (s, IH), 8.75 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.73 (d, 2H), 7.37 (d, 2H), 7.27 (t, 2H), 7.18 ( , 2H), 6.93 (d, 2H), 5.73 (s, 2H), 4.05 (s, 2H), 3.65 (q, 2H), 3.59 (dt, 2H), 3.28 (m, 2H), 3.17 (m, 2H), 1.95 (m, 2H), 1.75 (d, 2H), 1.52 (m, 2H). Example 519 N-(4-(4-benzyl-4-hydi-oxypiperidin- 1 -yl)benzoyl)-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide The desired product was prepared by substituting Example 496B and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 647 (M+H) + ; H NMR (500 MHz, DMSO-d 6 ) δ 11.93 (s, IH), 8.75 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.70 (d, 2H), 7.37 (d, 2H), 7.22 (m, 9H), 6.90 (d, 2H), 4.40 (s, IH), 3.65 (m, 4H), 3.28 (m, 2H), 3.17 (m, 2H), 2.70 (s, 2H), 1.50 (m, 2H), 1.45 (m, 2H). Example 520 N-(4-(2-azaspiro(4.4)non-2-yl)benzovP-4-((( lR)-3-(dimethylamino)- 1 - ((phenyltMo)methyl)propyl)-ιmino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 120C and Example 122G for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 652 (M+H) + ; H NMR (300 MHz, DMSO-de) δ 11.90 (s, IH), 8.55 (d, IH), 8.29 (d, IH), 7.87 (dd, IH), 7.73 (d, 2H), 7.24 (dd, 2H), 7.08-7.18 (m, 4H), 6.51 (d, 2H), 4.20 (m, IH), 3.35 (m, 4H), 3.15 (m, 4H), 2.74 (s, 6H), 2.14 (m, 2H), 1.86 (t, 2H), 1.65 (m, 4H), 1.55 (m, 4H). Example 521 ethyl 4-methyl- 1 -(4-((((3-nitro-4-((2- (phenyltlUo)ethyl)amino)phenyPsulfonyl)amino)carbonyl)phenyl)ρiperidine-4-carboxylate The desired product was prepared by substituting Example 532F and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 627 (M+H) + ; a NMR (300 MHz, DMSO-d 6 ) δ 11.98 (s, IH), 8.77 (t, IH), 8.60 (d, IH), 7.91 (dd, IH), 7.73 (d, 2H), 7.35 (m, 2H), 7.26 (t, 2H), 7.18 (m, 2H), 6.93 (d, 2H), 4.13 (m, 2H), 3.66 (m, 4H), 3.30 (m, 4H), 3.03 (m, 2H), 2.00 (m, 2H), 1.46 (m, 2H), 1.18 (t, 3H), 1.17 (s, 3H). Example 522 N-((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yPbenzoyPamino)sulfonyP-2-nitrophenyl)amino)- 6-(phenylthio)hexyl) acetamide The desired product was prepared by substituting acetic acid for N,N-dimethyglycine in Example 478. MS (ESI(+)) m/e 708, 706 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO- de) δ 8.53 (d, IH), 8.29 (d, IH), 7.85 (dd, IH), 7.73 (d, 2H), 7.25-7.09 (m, 5H), 6.92 (d, 2H), 4.12 (m, IH), 3.34 (m, 4H), 2.97 (m, 2H), 1.73 (s, 3H), 1.60 (m, 4H), 1.52-1.34 (m, 12H). Example 523 N-((5R)-5-((4-(((4-(8-az--sp o(4.5)dec-8-yl)benzoyPamino)sulfonyP-2-nitrophenvPamino)- 6-(phenylthio)hexyl)isonicotinamide The desired product was prepared by substituting isonicotinic acid for N,N- dimethylglycine in Example 478. MS (ESI) m/e 771.3, 769.4 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 8.69 (d, 2H), 8.52 (d, IH), 8.30 (d,lH), 7.84 (dd, IH), 7.73 (d, 2H), 7.70 (d, 2H), 7.09-7.25 (m, 5H), 6.92 (d, 2H), 4.12 (m, IH), 3.34 (m, 4H), 3.24 (m, 2H), 1.78 (m, 2H), 1.58 (m, 4H), 1.52-1.34 (m, 12H). ' Example 524 N -((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yl)benzoyl)amino)sulfonyl)-2-nitrophenvPamino)- 2 2 6-(phenylthio)hexyP-N -(2-carboxymethyP-N -methylglycinamide The desired product was prepared by substituting methyliminodiacetic acid for N,N- dimethylglycine in Example 478. MS (ESI) m/e 795.3, 793.4 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-de) δ 8.53(d, IH), 8.29(d,lH), 8.12 (m, IH), 7.85 (dd, IH), 7.73 (d, 2H), 7.25-7.09 (m, 5H), 6.92 (d, 2H), 4.12 (m, IH), 3.34 (m, 4H), 3.17 (s, 3H), 3.01 (m, 2H), 2.58 (m, 4H), 1.76 (m, 2H), 1.60 m, 4H), 1.52-1.34 (m, 12H). Example 525 N~l~-(C5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yPbenzovPamino)sulfonyl)-2- nitrophenyl)amino)-6-(phenylthio)hexyPglycinamide The desired product was prepared by substituting N-(t-butoxycarbonyl)glycine for N,N-dimethylglycine in Example 478. MS (ESI) m/e 723.3, 721.4 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 8.53 (d, IH), 8.30 (d,lH), 7.99 (m, 2H), 7.86 (dd, IH), 7.74 (d, 2H), 7.25-7.09 (m, 5H), 6.93 (d, 2H), 4.12 (m, IH), 3.34 (m, 4H), 3.09 (m, 2H), 1.75 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 12H). Example 526 N-((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yPberizoyPamino)sulfonyP-2-nitrophenvPamino)- 6-(phenylthio)hexyl)- 1 -methyl-L-proHnamide The desired product was prepared by substituting N-methylprohne for N,N- dimethylglycine in Example 478. MS (ESI) m/e 777.3, 775.4 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-d 6 ) δ 8.53 (d, IH), 8.51 (m, IH), 8.30 (d,lH), 7.86 (dd, IH), 7.73 (d, 2H), 7.58 (m, IH), 7.25-7.09 (m, 5H), 6.92 (d, 2H), 4.12 (m, IH), 3.89 (m, IH), 3.51 (m, IH), 3.34 (m, 4H), 3.10 (m, 2H), 3.01 (m, 2H), 2.74 (s, 3H), 1.78 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 14H). Example 527 N-((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yl)berizoyPamino)sulfonyl)-2-nitrophenyPamino)- 6-φhenylthio)hexyP- 1 -methylcyclopropanecarboxamide The desired product was prepared by substituting 1-methylcyclopropanecarboxylic acid for N,N-dimethylglycine in Example 478. MS (ESI) m e 748.3, 746.4 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-de) δ 8.53 (d, IH), 8.30 (d,lH), 7.84 (dd, IH), 7.73 (d, 2H), 7.39 (t, IH), 7.25-7.09 (m, 5H), 6.92 (d, 2H), 4.07 (m, IH), 3.34 (m, 4H), 3.09 (m, 2H), 1.74 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 12H), 1.16 (s, 3H), 0.85 (q, 2H), 0.40 (q, 2H). Example 528 N-((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yl)benzoyl) 6-(phenylthio)hexyP-2-hydroxyacetamide The desired product was prepared by substituting glycolic acid for N,N- dimethylglycine in Example 478. MS (ESI) m/e 724.3, 722.3 (M+H) + , (M-H) " ; 1H NMR (500 MHz, DMSO-de) δ 8.53 (d, IH), 8.30 (d, IH), 7.84 (dd, IH), 7.73 (d, 2H), 7.65 (t, IH), 7.25-7.09 (m, 5H), 6.92 (d, 2H), 4.09 (m, IH), 3.75 (s, 2H), 3.34 (m, 4H), 3.06 (m, 2H), 1.78 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 12H). Example 529 N-((5R)-5-((4-(((4-(8-azaspiro(4.5)dec-8-yl)benzoyl)amino)sulfonyl)-2-nitrophenyl)amino)- 6-(phenyltMo)hexyl)-2,2,2-trifluoroacetamide The desired product was prepared by substituting trifluoroacetic acid for N,N- dimethylglycine in Example 478. MS (ESI) m/e 762.2, 760.3 (M+H) + , (M-H) " ; H NMR (500 MHz, DMSO-de) δ 9.33 (t, IH), 8.53 (d, IH), 8.30 (d,lH), 7.84 (dd, IH), 7.73 (d, 2H), 7.25-7.09 (m, 5H), 6.92 (d, 2H), 4.09 (m, IH), 3.34 (m, 4H), 3.13 (m, 2H), 1.75 (m, 2H), 1.60 (m, 4H), 1.52-1.34 (m, 12H). Example 530 N-(4-(4-benzyl-4-methoxypiperidin- 1 -yl)benzoyl)-4-(.Y 1 R)-5-(dimethylamino)- 1 - ((phenylthio)methvPpentyPamino)-3-nitrobenzenesulfonamide Example 530A tert-butyl 4-benzyl-4-hydroxypiperidine- 1 -carboxylate A solution of 4-hydroxy-4-benzyl piperidine (0.66 g, 3.5 mmol) in IM NaOH (7 mL, 7 mmol) and dioxane (5 mL) at 0 °C was treated with BOC 2 O (0.76 g, 3.5 mmol), warmed to room temperature, stirred for 16 hours, adjusted to pH <7 with 10% citric acid, and extracted twice with ethyl acetate. The combined extracts were washed with water and brine, dried filtered, and concentrated to provide the desired product. Example 53 OB tert-butyl 4-benzyl-4-methoxypiperidine- 1 -carboxylate The desired product was prepared by substituting Example 530A for Example 494A in Example 494B. MS (DCI(+)) m/e 306 (M+H) + . Example 53 PC 4-benzyl-4-methoxypiperidine The desired product was prepared by substituting Example 530B for Example 494B in Example 494C. • ■ Example 530D tert-butyl 4-(4-benzyl-4-methoxypiperidin- 1 -ypbenzoate The desired product was prepared by substituting Example 530C for Example 494C in Example 494D. Example 530E 4-(4-benzyl-4-methoxypiperidin-l -ypbenzoie acid The desired product was prepared by substituting Example 530D for Example 493 A in Example 493B. Example 530F N-(4-(4-benzyl-4-methoxypiperidin- 1 -yl)benzoyP-4-((( 1 R)-5-(dimethylamino)- 1 - ((phenylthio)methyl)pentyl)amino -3-nitrobenzenesulfonamide The desired product was prepared by substituting Example 124E and Example 530E for Example IC and Example IB, respectively, in Example ID. MS(ESI(+)) m/e 760 (M+H) + ; H NMR (500 MHz, PMSO-d 6 ) δ 11.95 (s, IH), 9.20 (s, IH), 8.55 (d, IH), 8.31 (d, IH), 7.88 (dd, IH), 7.70 (d, 2H), 7.30-7.05 (m, HH), 6.90 (d, 2H), 4.10 (m, IH), 3.65 (m, 2H), 3.35 (m, 2H), 3.28 (s, 3H), 3.00 (m, 4H), 2.80 (s, 2H), 2.72 (s, 6H), 1.78 (m, 2H), 1.68 (m, 2H), 1.60 (m, 2H), 1.50 (m, 2H), 1.30 (m, 2H). Example 531 N-((4-benzylpiperidin- 1 -vPcarbonyl)-4-((( 1 R)-5-(dimethylamino)- 1 - ((phenylthio)methyPpentyPamino)-3-nitrobenzenesulfonamide The desired product was prepared by substituting Examle 124E and Example 488B for Example IC and Example IB, respectively, in Example IP. MS(ESI(+)) m/e 746 (M+H) + ; 1H NMR (500 MHz, DMSO-d 6 ) δ 11.95 (s, IH), 9.20 (s, IH), 8.55 (d, IH), 8.31 (d, IH), 7.88 (dd, IH), 7.70 (d, 2H), 7.30-7.05 (m, HH), 6.90 (d, 2H), 4.10 (m, IH), 3.65 (m, 2H), 3.15 (m, 2H), 2.95 (m, 2H), 2.70 (m, 8H), 1.75 (m, 2H), 1.60-1.25 (m, 9H). Example 532 N-(4-(4-(hydroxymethyP-4-methylpiperidin-l-yl)benzoyl)-3-nitro-4-((2- (pheny lthio) ethyl) amino)benzenesulfonamide Example 532A 1 -tert-butyl 4-ethyl piperidine- 1,4-dicarboxylate A solution of ethyl isonipecoate (2.5 g, 15.9 mmol) in dichloromethane (80 mL) at 0 °C was treated with (BOC^O (3.8 g, 17.3 mmol), warmed to room temperature, stirred for 2 hours, diluted with water, and extracted with dichloromethane. The combined extracts were washed sequentially with saturated sodium bicarbonate, 5% citric acid, and brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (ESI(+)) m/e 258 (M+H) + . Example 532B 1 -tert-butyl 4-ethyl 4-methylpiperidine- 1,4-dicarboxylate A solution of Example 532A (2.1 g, 8.1 mmol) in THF (81 mL) at -78 °C was treated dropwise with 1.5M LDA in cyclohexane (6.0 mL, 8.9 mmol), stirred for 30 minutes, treated dropwise with methyl iodide (0.76 mL, 12.1 mmol), stirred for 2.5 hours, quenched with saturated NH 4 CI, and extracted with diethyl ether. The combined extracts were washed with brine, dried (MgSO 4 ), filtered and concentrated to provide the desired product. MS (DCI) m/e 272 (M+H) + . Example 532C ethyl 4-methylpiperidine-4-carboxylate A solution of Example 532B (2.1 g, 8.0mmol) in 4M HCl in dioxane (10 mL) at room temperature was stirred for 3 hours and concentrated to provide the desired product. MS (DCI) m/e 171 (M+H) + . Example 532D benzyl 4-fluorobenzoate A mixture of 4-fluorobenzoic acid (4.9 g, 35.3 mmol), benzyl bromide (3.8 mL, 31.7 mmol), and cesium carbonate (17.2 g, 53 mmol) in DMF (50 mL) at room temperature was stirred for 24 hours, dUuted with water, and extracted with diethyl ether. The combined extracts were washed with brine, dried (MgSO 4 ), filtered, and concentrated to provide the desired product. MS (DCI) m/e 248 (M+H) + . Example 532E ethyl l-(4-((benzyloxy)carbonyl)phenyl)-4-methylpiperidine-4-carboxylate A mixture of Example 532C (2.2 g, 10.6 mmol), Example 532D (2.2 g, 9.9 mmol), and potassium carbonate (2.9 g, 21.2 mmol) in N-methylpyrrohdinone (8.8 mL) was stirred at 150 °C for 24 hours, cooled to room temperature, diluted with water, and ' extracted with dichloromethane. The combined extracts were washed with water and brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purified by flash column chromatogaphy on silica gel with 10% ethyl acetate/hexanes to provide the desired product. MS (DCI) m/e 382 (M+H) + Example 532F 4-(4-(ethoxycarbonvP-4-methylpiperidin- 1 -ypbenzoie acid A mixture of Example 532E (0.54 g, 1.4 mmol) in ethanol (6 mL) at room temperature was hydrogenated at 60 psi over 10% Pd/C (58 mg) for 1.5 hours, fUtered, and concentrated to provide the desired product. MS (DCI) m/e 292 (M+H) . Example 532G ethyl 4-methyl-l-(4-((((3-nitro-4-((2- (phenylthio)ethyl)amino)phenyl)sulfonyl)amino)carbonyl)phenyl)piperidine-4-carboxylate The desired product was prepared by substituting Example 532F and Example 77B for Example IB and Example IC, respectively, in Example ID. MS (ESI(+)) m/e 627 (M+H) + . Example 532H 4-methyl-l-r4-((((3-nitro-4-((2- (phenyltlno)ethyPammo)phenyl)sulfonyl)amino)carbonyPphenyl)ρiperidine-4-carboxylic acid The desired product was prepared by substituting Example 532G for Example 119B in Example 119C. MS (ESI(+)) m/e 599. Example 5321 N-(4-(4-(hydroxymethyP-4-methylpiperidin-l-yPbenzoyP-3-nitro-4-((2- (phenylthio)ethyPamino)benzenesulfonamide A solution of Example 532H (35 mg, 0.06 mmol), 4-methylmoφhoHne (0.007 mL, 0.06 mmol), and DME (0.3 mL) at -15 °C was treated dropwise with isobutyl chloroformate (0.008 mL, 0.06 mmol), stirred for 15 minutes, and filtered. The filter cake was washed with PME and the filtrate and washings were combined. The solution was cooled to -15 °C, treated sequentially with NaBHt (3.5 mg, 0.09mmol) water (0.03 mL), and additional water (50 mL), and extracted with dichloromethane. The combined extracts were washed with brine, dried (MgSO 4 ), filtered, and concentrated. The concentrate was purifed by flash column chromatography on silica gel with 1-2% methanoPdichloromethane to provide the desired product. MS (ESI(-))) m/e 583 (M-H)-; H NMR (500 MHz, OMSO-d 6 ) δ 11.92 (s, IH), 8.75 (t, IH), 8.58 (d, IH), 7.90 (dd, IH), 7.72 (d, 2H), 7.38 (d, 2H), 7.27 (t, 2H), 7.15 (m, 2H), 6.90 (d, 2H), 4.53 (t, IH), 3.66 (m, 2H), 3.50 (m, 2H), 3.30 (m, 2H), 3.16 (m, 4H), 1.50 (m, 2H), 1.25 (m, 2H), 0.91 (s, 3H). Example 533 N-(4-(4-(2-naphthylsulfonyPpiperazin-l-ypbenzoyl)-3-nitro-4-((2- (phenylthio)ethyl)amino)benzenesulfonamide The desired product was prepared by substituting 2-napthalenesulfonyl chloride for 2- methoxyethyl chloroformate in Example 325. MS (ESI(-)) m/e 730 (M-H) " ; H NMR (500 MHz, OMSO-de) δ 12.02 (s, IH), 8.74 (t, IH), 8.57 (d, IH), 8.46 (d, IH), 8.21 (d, IH), 8.16 (d, IH), 8.06 (d, IH), 7.88 (dd, IH), 7.77 (dd, IH), 7.76-7.66 (m, 4H), 7.37-7.32 (m, 2H), 7.25 (t, 2H), 7.19-7.14 (m, 2H), 6.89 (d, 2H), 3.65 (q, 2H), 3.42 (t, 4H), 3.26 (t, 2H), 3.07 (t, 4H). Example 534 4-(((lR)-5-( amino(imino)methyPamino)-l-((phenylthio)methyl)pentyl)amino)-N-(4-(8- azaspiro(4.5)dec-8-yl)benzoyl)-3-nitrobenzenesulfonamide A solution of Example 287 (30 mg, 0.05 mmol), aminoiminosulfonic acid (7 mg, 0.055 mmol), dusopropylethylamine (0.02 Ml), and OMF (0.3 mL) at room temperature was stirred for 24 hours and concentrated. The concentrate was purified by reverse phase chromatography with 0-90% methanol/0.1% aqueous TFA to provide the desired product. MS (ESI(+)) m/e 708 (M+H) + ; 1H NMR (500 MHz, PMSO-d 6 ) δ 12.02 (s, IH), 8.53 (d, IH), 8.32 (d, IH), 7.86 (dd, IH), 7.73 (d, 2H), 7.39 (t, IH), 7.25-7.10 (m, 6H), 6.93 (d, 2H), 4.12 (m, IH), 3.35 (m, 6H), 3.05 (m, 2H), 1.75 (m, 2H), 1.59 (m, 4H), 1.42 (m, 8H). It wUl be evident to one skUled in the art that the present invention is not limited to the forgoing Ulustrative examples, and that it can be embodied in other specific forms without departing from the essential attributes thereof. It is therefore desired that the examples be considered in aU respects as Ulustrative and not restrictive, reference being made to the appended claims, rather than to the foregoing examples, and all changes which come within the meaning and range of equivalency of the claims and therefore intended to be embraced therein.

Claims: WHAT IS CLAIMEO IS 1. A compound of formula (I), or a therapeutically acceptable salt thereof, wherein A is selected from the group consisting of phenyl and a five- or six-membered aromatic carbocyclic ring wherein from one to three carbon atoms are replaced by a heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur, and wherein A is substituted through carbon atoms in the ring; R is selected from the group consisting of alkyl, haloalkyl, nitro, and -NR 5 R 6 ; 2 3 R , and R are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkyl, alkylsulfanyl, alkynyl, aryl, arylalkoxy, aryloxy, aryloxyalkoxy, arylsulfanyl, arylsulfanylalkoxy, carbonyloxy, cycloalkylalkoxy, cycloalkyloxy, halo, haloalkoxy, haloalkyl, heterocycle, (heterocycle)oxy, hydroxy, nitro, and -NR 5 R 6 , R is selected from the group consisting of aryl, arylalkenyl, arylalkoxy, cycloalkenyl, cycloalkyl, halo, heterocycle, and (heterocycle)alkoxy; R and R are independently selected from the group consisting of hydrogen, alkenyl, alkoxyalkyl, alkoxycarbonylalkyl, alkyl, alkylsulfanylalkyl, alkylsulfonylalkyl, aryl, arylalkyl, arylalkylsulfanylalkyl, aryloxyalkyl, arylsulfanylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, carboxyalkyl, cycloalkenyl, cycloalkenylalkyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkylcarbonyl, heterocycle, (heterocycle)alkyl, 7 8 (heterocycle)sulfanylalkyl, hydroxyalkyl, a nitrogen protecting group, and -N=CR R ; or R and R , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of imidazolyl, moφholinyl, piperazinyl, piperidinyl, pyrroHdinyl, pyrrolyl, thiomoφhohnyl, and thiomoφholinyl dioxide; and 7 8 R and R are alkyl, or 7 8 R and R , together with the carbon atom to which they are attached, form an aryl group; and 15 R is selected from the group consisting of hydrogen, alkyl, and halo. 2. A compound according to Claim 1 wherein A is selected from the group consisting of phenyl, pyridinyl, and furyl. 3 3. A compound according to Claim 2 wherein R is selected from the group consisting of hydrogen, alkenyl', aryl, and heterocycle. 4. A compound according to Claim 3 wherein R is selected from the group consisting of arylsulfanylalkoxy, cycloalkylalkoxy, and cycloalkyloxy. 5. A compound according to Claim 3 wherein . 6. A compound according to Claim 5 wherein one of R and R is selected from the group consisting of alkyl, aryl, arylalkyl, arylalkylsulfanylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, cycloalkylcarbonyl, heterocycle, (heterocycle) alkyl, 7 8 heterocyclesulfanylalkyl, and -N=CR R ; and the other is hydrogen. 7. A compound according to Claim 5 wherein one of R and R is (cycloalkyl)alkyl and the other is arylsulfanylalkyl. 8. A compound according to Claim 5 wherein one of R and R is cycloalkyl and the other is hydrogen. 9. A compound according to Claim 5 wherein one of R and R is (cycloalkyl)alkyl and the other is hydrogen. 10. A compound according to Claim 5 wherein one of R and R is arylsulfanylalkyl and the other is hydrogen. 11. A compound according to Claim 10 wherein R is selected from the group consisting of arylalkenyl, arylalkoxy, cycloalkenyl, cycloalkyl, and (heterocycle) alkoxy. 12. A compound according to Claim 10 wherein R is aryl. 13. A compound according to Claim 12 wherein the aryl is unsubstituted or has one substituent. 14. A compound according to Claim 12 wherein the aryl has two substituents. 15. A compound according to Claim 10 wherein R is heterocycle. 16. A compound according to Claim 15 wherein the heterocycle is unsubstituted or has one substituent. 17. A compound according to Claim 15 wherein the heterocycle has two or three substituents. 18. A pharmaceutical composition comprising a compound of Claim 1 or a therapeutically acceptable salt thereof, in combination with a therapeutically acceptable carrier. 19. A method of promoting apoptosis in a mammal in recognized need of such treatment comprising administering to the mammal a therapeutically acceptable amount of a compound of Claim 1, or a therapeutically acceptable salt thereof.

Inventors: AUGERI DAVID J, BAUMEISTER STEVEN A, BRUNCKO MILAN, DICKMAN DANIEL A, DING HONG, DINGES JURGEN, FESIK STEPHEN W, HAJDUK PHILIP J, KUNZER AARON R, MCCLELLAN WILLIAM, NETTESHEIM DAVID G, OOST THORSTEN, PETROS ANDREW M, ROSENBERG SAUL H, SHEN WANG, THOMAS SHEELA A, WANG XILU, WENDT MICHAEL D, AUGERI, DAVID, J., BAUMEISTER, STEVEN, A., BRUNCKO, MILAN, DICKMAN, DANIEL, A., DING, HONG, DINGES, JURGEN, FESIK, STEPHEN, W., HAJDUK, PHILIP, J., KUNZER, AARON, R., MCCLELLAN, WILLIAM, NETTESHEIM, DAVID, G., OOST, THORSTEN, PETROS, ANDREW, M., ROSENBERG, SAUL, H., SHEN, WANG, THOMAS, SHEELA, A., WANG, XILU, WENDT, MICHAEL, D.
Applicants: ABBOTT LAB, ABBOTT LABORATORIES
Application year: 2001
Main classification: C07C311
IPC codes: A61K31, A61P9, A61P25, A61P29, A61P31, A61P35, A61P37, C07C311, C07C317, C07C323, C07D203, C07D205, C07D207, C07D209, C07D211, C07D213, C07D215, C07D217, C07D221, C07D231, C07D233, C07D235, C07D241, C07D249, C07D263, C07D277, C07D295, C07D307, C07D317, C07D333, C07D401, C07D405, C07D417, C07D451, C07D491