COSMETIC COMPOSITIONS CONTAINING VITAMIN B3

Abstract: The present invention relates to cosmetic compositions, comprising: a) from about 0.01 % to about 50 %, by weight, of vitamin B3 compound; b) from about 0 % to about 90 %, by weight, of an emollient component comprising from 0 % to about 100 %, by weight, of an oil liquid at ambient temperature; c) from about 0.01 % to about 40 %, by weight, of a polar solvent; d) from about 0 % to about 90 %, by weight, of a solidifying agent; and e) from about 0 % to about 90 %, on an anhydrous basis, of a color wherein the vitamin B3 compound is added to the composition such that the concentration of the vitamin B3 compound exceeds the saturation solubility of the vitamin B3 compound in the polar solvent.

Description: COSMETIC COMPOS ITIONS CONTA INING VITAMIN B3 FIELD OF THE INVENTION The present invention relates to cosmetics containing partially dissolved crystalline vitamin B 3 compounds BACKGROUND OF THE INVENTION Niacm, also known as vitamin B 3 , is the common name for nicotinic acid The physiologically active form of macm is macmamide, also a member of the vitarmn B 3 family of compounds Niacm and niacinamide (nicotmic acid amide) function in the body as components of two coenzymes mcotinamide ademne dinucleotide (NAD) and nicotmamide adenine dinucleotide phosphate (NADP) Until recently, these vitarmn B 3 compounds were used exclusively to treat macm deficiency and pellegra Today, however, vitamin B 3 compounds have also found use in the area of skin care actives British Patent 1,370,236 describes compositions for skm lightening contaimng 0 5% to 10% macin Similarly, U S Patent 4,096,240 discloses the use of 0 1% to 10% macmamide for skin lightening Vitamin B 3 compounds have also been found useful in regulating the texture of human skin See PCT application WO 97/39733, to Oblong et al However, when topically applied to the skm, only about 2-4% of the applied vitamm B 3 compound actually penetrates into the skm Thus, there exists a need for cosmetic compositions comprising vitamin B 3 compounds which provide improved skin penetration of vitarmn B 3 compounds The present inventors have discovered that cosmetic compositions which incorporate vitamm B 3 compounds in a polar solvent such that the vitamin B 3 compound exceeds the saturation solubility of the polar solvent improves the overall skm penetration of the vitamin B 3 compound It is, therefore, an aspect of the present invention to provide cosmetic compositions which enhance the amount of topically applied vitamm B3 compounds which penetrates the skin Another aspect of the present invention is to provide cosmetic compositions comprising a polar solvent and vitamin B 3 compounds as undissolved crystals A further aspect of the present mvention is to provide lipstick compositions comprising a polar solvent and vitamin B 3 compounds as undissolved crystals These and other aspects will become readily apparent from the detailed descπption which follows SUMMARY OF THE INVENTION The present invention relates to cosmetic compositions, compπsmg a ) from about 0 01% to about 50%, by weight, of vitamm B 3 compound, b ) from about 0% to about 90%, by weight, of an emollient component compπsmg from 0% to about 100%, by weight, of an oil liquid at ambient temperature, c ) from about 0 01% to about 80%, by weight, of a polar solvent, d ) from about 0% to about 30%, by weight of a surfactant, e.) from about 0% to about 90%, by weight, of a solidifying agent; and f ) from about 0% to about 90%, by weight, of a color wherein the vitamin B 3 compound is added to the composition such that the concentration of the vitamm B 3 compound exceeds the saturation solubility of the vitamm B 3 compound in the composition All percentages, parts and ratios are based upon the total weight of the cosmetic compositions of the present invention, unless otherwise specified All such weights as they pertam to listed mgredients are based on the active level and. therefore, do not mclude carriers or by-products that may be included m commercially available matenals, unless otherwise specified. DETAILED DESCRIPTION OF THE INVENTION As used herem the term "comprising" means that the composition can contain other mgredients which are compatible with the composition and which preferably do not substantially disrupt the compositions of the present mvention The term encompasses the terms "consisting of and "consistmg essentially of As used herein, the term "cosmetics" includes make-up, foundation, and skm care products. The term "make-up" refers to products that leave color on the face, mcludmg foundation, blacks and browns, i.e., mascara, concealers, eye lmers, brow colors, eye shadows, blushers, lip colors, and so forth. Skm care products are those used to treat or care for, or somehow moisturize, improve, or clean the skm. Products contemplated by the phrase "skm care products" include, but are not limited to, adhesives, bandages, toothpaste, anhydrous occlusive moisturizers, antipersp rants, deodorants, powder laundry detergent, fabπc softener towels, occlusive drug delivery patches, nail polish, powders, tissues, wipes, solid emulsion compact, hair conditioners-anhydrous and the like. The term "foundation" refers to liquid, creme, mousse, pancake, compact, concealer or like product created or remtroduced by cosmetic companies to even out the overall coloring of the skm. Foundation is manufactured to work better over moisturized and or oiled skm. ESSENTIAL COMPONENTS Vitamin B3 Component The compositions of the present invention comprise a safe and effective amount of a natural or synthetic vitamm B3 compound The compositions of the present invention preferably comprise from above 0.01% to about 50%, more preferably from about 0.1% to about 30%, even more preferably 0 5% to about 20%, most preferably from about 1% to about 10% of the vitarmn B3 compound. As used herein, "vitamm B3 compound" means a compound having the formula: wherein R is - CONH2 (1 e , macmamide), - COOH (1 e , nicotmic acid) or - CH2OH (1 e , mcotmyl alcohol), derivatives thereof, and salts of any of the foregomg Exemplary derivatives of the foregomg vitamm B3 compounds mclude nicotinic acid esters, including non-vasodilating esters of nicotmic acid, mcotmyl ammo acids, nicotmyl alcohol esters of carboxylic acids, nicotmic acid N-oxide and macmamide N-oxide Suitable esters of nicotinic acid mclude nicotmic acid esters of C1 -C22, preferably Ci -Ci g, more preferably C j -Cg alcohols The alcohols are suitably straight-chain or branched cham, cyclic or acyclic, saturated or unsaturated (mcludmg aromatic), and substituted or unsubstituted The esters are preferably non-rubifacient As used herein, "non-rubifacient" means that the ester does not commonly yield a visible flushing response after application to the skm m the subject compositions (the majority of the general population would not experience a visible flushing response, although such compounds may cause vasodilation not visible to the naked eye) Alternatively, a nicotmic acid material which is rubifacient at higher doses could be used at a lower dose to reduce the rubifacient effect Non-rubifacient esters of nicotinic acid mclude tocopherol mcotmate and mositol hexanicotmate, tocopherol nicotinate is preferred Other derivatives of the vitamin B3 compound are derivatives of macmamide resultmg from substitution of one or more of the amide group hydrogens Nonlimitmg examples of derivatives of macmamide useful herein mclude nicotmyl ammo acids, derived, for example, from the reaction of an activated nicotmic acid compound (e g , nicotmic acid azide or mcotmyl chloride) with an ammo acid, and nicotmyl alcohol esters of organic carboxylic acids (e g , Cl - C18) Specific examples of such derivatives include mcotmuric acid and nicotmyl hydroxamic acid, which have the following chemical structures nicotinuπc acid nicotmyl hydroxamic acid Exemplary nicotmyl alcohol esters include mcotmyl alcohol esters of the carboxylic acids salicylic acid, acetic acid, glyco c acid, palmitic acid and the like Other non-limiting examples of vitamin B3 compounds useful herein are 2-chloronιcotmamιde, 6-amιnomcotιnamιde, 6-methylmcotιnamιde, n-mefhyl- nicotinamide, n,n-dιethylmcotιnamιde, n-(hydroxymethyl)-nιcotιnamιde, qumohmc acid imide, nicotmamlide, n-benzylmcotinamide, n-ethylmcotmamide, mfenazone, mcotinaldehyde, isomcotimc acid, methyl isomcotimc acid, thiomcotinamide, malamide, l-(3-pyπdylmethyl) urea, 2-mercaptonιcotιnιc acid, mcomol, and maprazine Examples of the above vitamin B3 compounds are well known in the art and are commercially available from a number of sources, e g , the Sigma Chemical Company (St Louis, MO), ICN Biomedicals, Inc (Irvin, CA) and Aldπch Chemical Company (Milwaukee, WI) One or more vitamin B3 compounds may be used herein Preferred vitamin B3 compounds are macmamide and tocopherol mcotmate Niacmamide is more preferred When used, salts, denvatives, and salt derivatives of niacmamide are preferably those havmg substantially the same efficacy as macmamide in the methods of regulating skm condition described herem Salts of the vitarmn B3 compound are also useful herein Nonlimitmg examples of salts of the vitamm B3 compound useful herein include orgamc or inorganic salts, such as inorganic salts with amonic inorganic species (e g , chloride, bromide, iodide, carbonate, preferably chloride), and orgamc carboxylic acid salts (mcludmg mono-, di- and tn- Cl - C18 carboxylic acid salts, e g , acetate, sahcylate, glycolate, lactate, malate, citrate, preferably monocarboxy c acid salts such as acetate) These and other salts of the vitamm B3 compound can be readily prepared by the skilled artisan, for example, as described by W Wenner, "The Reaction of L-Ascorbic and D-Isoascorbic Acid with Nicotmic Acid and Its Amide", J Orgamc Chemistry, VOL 14, 22-26 (1949), which is incorporated herein by reference Wenner describes the synthesis of the ascorbic acid salt of macmamide In a preferred embodiment, the ring nitrogen of the vitamin B3 compound is substantially chemically free (e g , unbound and/or unhmdered), or after delivery to the skm becomes substantially chemically free ("chemically free" is hereinafter alternatively referred to as "uncomplexed") More preferably, the vitamin B3 compound is essentially uncomplexed Therefore, if the composition contains the vitamm B3 compound m a salt or otherwise complexed form, such complex is preferably substantially reversible, more preferably essentially reversible, upon delivery of the composition to the skm For example, such complex should be substantially reversible at a pH of from about 5 0 to about 6 0 Such reversibility can be readily determined by one having ordinary skill in the art More preferably the vitamin B3 compound is substantially uncomplexed in the composition pnor to delivery to the skin Exemplary approaches to minimizing or preventing the formation of undesirable complexes include omission of materials which form substantially irreversible or other complexes with the vitamin B3 compound, pH adjustment, ionic strength adjustment, the use of surfactants, and formulatmg wherein the vitamm B3 compound and materials which complex therewith are in different phases. Such approaches are well within the level of ordinary skill in the art Thus, in a preferred embodiment, the vitamm B3 compound contams a limited amount of the salt form and is more preferably substantially free of salts of a vitamin B3 compound. Preferably the vitamm B3 compound contains less than about 50% of such salt, and is more preferably essentially free of the salt form The vitamm B3 compound in the compositions hereof havmg a pH of from about 4 to about 7 typically contain less than about 50% of the salt form. The vitarmn B3 compound may be mcluded as the substantially pure material, or as an extract obtained by suitable physical and/or chemical isolation from natural (e.g., plant) sources. The vitamm B3 compound is preferably substantially pure, more preferably essentially pure. The cosmetic compositions of the present invention comprise the vitamin B 3 compounds and the polar solvent at concentrations such that the concentration of the vitamm B 3 compound exceeds the saturation solubility (at ambient temperature; say, at about 20°C) of the vitarmn B 3 compound m the composition. As a result, a portion of the vitamm B 3 compound is present in undissolved form. Preferably , the concentration of the vitamin B 3 compound will be at least 50% greater than the saturation solubility at ambient temperature, more preferably at least 100% greater than the saturation solubility at ambient temperature and most preferably at least 150% greater or more than the saturation solubility at ambient temperature of the vitamin B 3 compound in the composition. Polar Solvent Solvents suitable for use in the present invention mclude any polar solvent capable of dissolving the vitamin B 3 compound Suitable polar solvents include- water; alcohols, such as ethanol, propyl alcohol, isopropyl alcohol, hexanol, and benzyl alcohol; polyols, such as propylene glycol, polypropylene glycol, butylene glycol, hexylene glycol, maltitol, sorbitol, and glycerme; panthenol dissolved in glycerine; flavor oils, and mixtures thereof Mixtures of these solvents can also be used Preferred polar solvents are polyhydπc alcohols and water. Examples of preferred solvents mclude glycerme, panthenol in glycerme, glycols such as propylene glycol and butylene glycol, polyethylene glycols, water and mixtures thereof The most preferred polar solvents for use are alcohols, glyceπne, panthenol, propylene glycol, butylene glycol hexylene glycol and mixtures thereof. Typically, the cosmetic compositions of the present invention will comprise from about 0.1% to about 80%, preferably from about 0 5% to about 60%, more preferably from about 1% to about 30% and most preferably from about 3% to about 18% polar solvent Optional Components Emollient Component Also essential to the compositions of the present invention is an emollient component. The emollient component can comprise fats, oils, fatty alcohols, fatty acids and esters which aid application and adhesion, yield gloss and most importantly provide occlusive moistunzation Suitable emollients for use are isosteanc acid derivatives, isopropyl palmitate, lanolm oil, dusopropyl dimerate, maleated soybean oil, octyl palmitate, isopropyl isostearate, cetyl lactate, cetyl ncmoleate, tocopheryl acetate, acetylated lanolm alcohol, cetyl acetate, phenyl tnmethicone, glyceryl oleate, tocopheryl hnoleate, wheat germ glyceπdes, arachidyl propionate, mynstyl lactate, decyl oleate, propylene glycol ricinoleate, isopropyl lanolate, pentaerythntyl tetrastearate, neopentylglycol dicaprylate/dicaprate, hydrogenated coco-glycendes, isononyl isononanoate, lsotndecyl isononanoate, myristal mynstate, tnisocetyl citrate, cetyl alcohol, octyl dodecanol, oleyl alcohol, panthenol, lanolm alcohol, linoleic acid, linolenic acid, sucrose esters of fatty acids, octyl hydroxystearate and mixtures thereof Examples of other suitable emollients can be found m the Cosmetic Bench Reference, pp 1 19- 1 22 (1996) Particularly preferred emollients are polar emollient emulsifiers such as linear or branched chained polyglycerol esters By "polar emollient," as used herein, means any emollient emulsifier having at least one polar moiety and wherein the solubility (at 30°C) of the vitamin B 3 compound is m the polar emollient is greater than about 1 5%, preferably greater than about 2%, more preferably greater than about 3% Suitable polar emollients mclude, but are not limited to, polyol ester and polyol ethers such as linear or branched chained polyglycerol esters and polyglycerol ethers Nonlimitmg examples of such emollients include PG3 dnsosterate, polyglyceryl-2-sesqunsostearate, polyglyceryl-5-dιstearate, polyglyceryl-10- distearate, polyglyceryl-10-dιιsostearate, acetylated monoglyceπdes, glycerol esters, glycerol tncaprylate/caprate, glyceryl ncmoleate, glyceryl isostearate, glyceryl mynstate, glyceryl l noleate, polyalkylene glycols such as PEG 600, monoglyceπdes, 2-monolauπn, sorbitan esters and mixtures thereof Also preferred are non-polar emollients By "non-polar emollient," as used herein, means any emollient emulsifier possessmg no permanent electnc moments and wherein the solubility (at 30°C) of the vitamm B 3 compound is m the polar emollient is less than about 1 5% preferably less than about 1 0%, more preferably less than about 0 5% Suitable non-polar emollients include, but are not limited to, esters and linear or branched chamed hydrocarbons Nonlimitmg examples of such emollients isononyl isononanoate, isopropyl isostearate, octyl hydroxystearate, dusopropyl dimerate, lanolin oil, octyl palmitate, isopropyl palmitate, paπffins, isoparnfins, acetylated lanolin, sucrose fatty acid esters, isopropyl mynstate, isopropyl stearate, mineral oil, si cone oils, dimethicone, allantom, isohexadecane, isododecane, petrolatum, and mixtures thereof The solubility of the vitamm B3 compound in polar or non-polar emollients is determined as set forth below Suitable oils include esters, tnglycendes, hydrocarbons and sihcones These can be a smgle material or a mixture of one or more materials They will normally compnse from 0% to about 100%, preferably from about 5% to about 90%, and most preferably from about 70% to about 90% of the emollient component Oils act as emollients and also impart viscosity, tackiness, and drag properties to cosmetic compositions such as lipsticks Examples of suitable oils include capryhc tnglycendes, capnc tnglycende, isosteanc tnglycende; adipic tnglycende, propylene glycol mynstyl acetate; lanolm: lanolin oil, polybutene; isopropyl palmitate; isopropyl mynstate; isopropyl isostearate; diethyl sebacate; dusopropyl adipate; tocopheryl acetate; tocopheryl hnoleate; hexadecyl stearate; ethyl lactate, cetyl oleate; cetyl ncmoleate; oleyl alcohol; hexadecyl alcohol, octyl hydroxystearate; octyl dodecanol, wheat germ oil; hydrogenated vegetable oils; castor oil, petrolatum; modified lanolms; branched-chain hydrocarbons; alcohols and esters; corn oil; cottonseed oil; olive oil; palm kernel oil; rapeseed oil; safflower oil, jojoba oil; evening primrose oil, avocado oil mineral oil, sheabutter, octylpalmitate, maleated soybean oil, glycerol trioctanoate, dusopropyl dimerate, and volatile and non-volatile si cone oils mcludmg phenyl tnmethicone. The preferred oils for use herein are acetylglyceπdes, octanoates, and decanoates of alcohols and polyalcohols, such as those of glycol and glycerol, the πcinoleates of alcohols and polyalcohols such as cetyl ricinoleate, PG-3 dnsostearate, polyglycerol ethers, polyglycerol esters, capryhc tnglycendes, capnc tnglycendes, isosteanc tnglycende, adipic tnglycende, phenyl tnmethicone, lanolin oil. polybutene, isopropyl palmitate, isopropyl isostearate, cetyl ricinoleate, octyl dodecanol, oleyl alcohol, hydrogenated vegetable oils, castor oil, modified lanolms, octyl palmitate, lanolin oil, maleated soybean oil, cetyl ncmoleate, glyceryl trioctanoate, dusopropyl dimerate, synthetic lanolm derivatives and branched cham alcohols, sucrose esters of fatty acids, octyl hydroxystearate and mixtures thereof. Preferably, the oils used are selected such that the majority (at least about 75%, preferably at least about 80% and most preferably at least about 99%) of the types of oils used have solubility parameters which do not differ by more than from about 1 to about 0.1 , preferably from about 0.8 to about 0.1. The emollient component compnses from about 1% to about 90%, preferably from about 10% to about 80%, more preferably from about 20% to about 70%, and most preferably from about 40% to about 60%, of the cosmetic composition Surfactants Surfactants suitable for use are those which can form emulsions and/or association structures. Surfactant emulsifier can be from 0% to about 20% of the formulation, preferably from 0% to about 15% and most preferably from about 1% to about 10% Examples of suitable emulsifiers can be found in U S Patent 5,085,856 to Dunphy et al, Japanese Patent Publication Sho 61-83110; European Patent Application EP 522624 to Dunphy et al., U.S. patent 5,688,831 to El-Nokaly et al.. Examples of other suitable emulsifiers can be found m Cosmetic Bench Reference, pp. 1.22, 1.24-1.26 (1996), all of which are herem mcorporated by reference in their entirety. Also useful herem are surfactants which form association structures, preferably lamellar or hexagonal liquid crystals, at ambient temperature when mixed with a polar solvent Ambient temperature/room temperature as used herem typically means about 20°C. Generally ambient temperature can range from about 18°C to about 27°C, preferably from about 20°C to about 25°C, depending on such vanables as geographical location, I e. sub-tropical vs. temperate regions. One of ordinary skill m the art is able to determine if association structures form at ambient temperatures The surfactants suitable for use generally have a Krafft pomt at or below about ambient temperature about 20 C C or generally at or below about 18°C to about 27°C, preferably at or below from about 20°C to about 25°C The definition of Krafft point is well known m the art and one of ordinary skill in the art can determine a surfactant's Krafft point In general terms, Krafft point is the meltmg point of the hydrocarbon chains of the surfactants It can also be expressed as the temperature at which the solubility of an association colloid in water suddenly increases because critical micelle concentration is exceeded and micelles form See Ekwall , P , "Composition, Properties and Structure of Liquid Crystallme IPhases in Systems of Amphiphihc Compounds" Advances in Liquid Crystals Vol I, Chapter I, p 81 In preparing a sample combination of surfactant and polar solvent to demonstrate the ability to form association structures, the surfactant needs to be sufficiently soluble m the polar solvent such that an association structure can form at ambient temperature One of ordinary skill m the art is capable of determining compatible interactions Any surfactant which forms association structures at ambient temperature and is suitable for use in cosmetics is suitable for use herem Surfactants suitable for use in cosmetics do not present dermatological or toxicological problems Amonic surfactants, nomomc surfactants, cationic surfactants, amphotenc surfactants and mixtures thereof are suitable for use Preferably aniomc surfactants, nomomc surfactants, cationic surfactants, amphotenc surfactants and mixtures thereof having a Krafft point at or below about ambient temperature are used More preferably, nomomc surfactants, catiomc surfactants, amphotenc surfactants and mixtures thereof havmg a Krafft pomt at or below about ambient temperature are used Surfactants suitable for use m forming association structures are found in U S Patent 5,843,407 to El-Nokaly, herem incorporated by reference The association structures of the present invention are also useful in improvmg the skin penetration of the vitamin B 3 compound Without bemg limited by theory, the association structures are believed to act as occlusives on the skm by forming continuous or discontinuous bi-layer or multi-layer films on the skm The term "occlusive," as used herein, means a preventing or obstructing something, in this case, preventmg the removal of moisture (via evaporation) and the vitamm B 3 compound (via film bmdmg) from the surface of the skm Furthermore, since the association structures of the present invention are thermodynamically stable, it is believed that the entrapped or bound polar solvent is slowly released over time The slow release of the polar solvent thereby aids in maintaining the vitamm B 3 compound m solubilized form, thus, improvmg skin penetration of the vitamm B 3 compound This occlusive effect is even further enhanced by the addition of the waxy or wax-like (or gel-like) solidifying agents disclosed above The surfactants can be used at levels from about 4% to about 97%, preferably from about 5% to about 95%, more preferably from about 20% to about 90% and most preferably from about 30% to about 70% of the association structure Solidifying Agent The cosmetic compositions of this mvention can contam one or more matenals, herem singly or collectively referred to as a " solidifying agent" , that are effective to so difv the particular liquid base materials to be used in a cosmetic composition. (As used herem, the term "solidify" refers to the physical and/or chemical alteration of the liquid base material so as to form a solid or semi-solid at ambient conditions, i.e., to form a final composition which has a stable physical structure and is deposited on the skm dunng normal use conditions.) As is appreciated by those skilled in the art, the selection of the particular solidifying agent for use in the cosmetic compositions will depend upon the particular type of composition desired, i.e., gel or wax-based, the desired rheology, the liquid base matenal used and the other materials to be used m the composition The solidifying agent is preferably present at a concentration of from about 0 to about 90%, more preferably from about 1 to about 50%, even more preferably from about 5% to about 40%, most preferably from about 3% to about 20%. The wax cosmetic stick embodiments of this invention preferably contain from about 5% to about 50% (by weight) of a waxy solidifying agent. By the term "waxy solidifying agent," as used herem, is meant a solidifying material havmg wax-like charactenstics Such waxy matenals may also serve as emollients Among the waxy materials useful herem are the high meltmg pomt waxes, i.e., havmg a meltmg pomt of from about 65°C to about 125°C, such as beeswax, spermaceti, carnauba, baysberry, candehlla, montan, ozokerite, ceresm, paraffin, synthetic waxes such as Fisher-Tropsch waxes, microcrystallme wax, and mixtures thereof. Ceresm, ozokerite, white beeswax, synthetic waxes, and mixtures thereof, are among the preferred high-melting point waxes useful herem. Compositions contammg waxes among those useful herein are disclosed in U.S. Patent 4,049,792, Elsnau, issued Sept. 20, 1977, herein incorporated by reference m its entirety) Low meltmg waxes, havmg a meltmg pomt of from about 37°C to about 75°C, are preferred for use in the wax stick embodiments of this invention. Wax stick embodiments of this mvention, which contam volatile sihcone oils as a liquid base matenal, preferably contam from about 10% to about 35%, more preferably from about 10% to about 20% (by weight), of a low-melting wax. Such materials include fatty acids, fatty alcohols, fatty acid esters and fatty acids amides, havmg fatty chains of from about 8 to about 30 carbon atoms, and mixtures thereof. Preferred wax-like materials include cetyl alcohol, palmitic acid, stearyl alcohol, behenamide, sucrose esters of tallow fatty acids, mono and di-fatty acid esters of polyethylene glycol, and mixtures thereof. Stearyl alcohol, cetyl alcohol, and mixtures thereof, are particularly preferred Fatty acids, fatty alcohols, and other wax-like materials useful in this mvention are also disclosed in the following refences, all of which are incorporated by reference herem: U.S Patent 4,151,272, Geary, et al , issued Apr. 24, 1979; U.S. Patent 4,229,432, Geπa, issued Oct. 21, 1980; and U.S. Patent 4,280,994, Turney, issued July 28, 1981; "The Chemistry and Technology of Waxes", A. H. Warth, 2nd Edition, reprinted m 1960, Reinhold Publishing Corporation, pp 391-393 and 421, "The Petroleum Chemicals Industry", R F. Goldstem and A. L Waddeam, 3rd Edition (1967), E & F N. Span Ltd., pp 33-40, "The Chemistry and Manufacture of Cosmetics", M. G. DeNavarre, 2nd edition ( 1970), Van Nostrand & Company, pp 354-376; and m "Encylopedia of Chemical Technology:, Vol. 24, Kirk-Othmer, 3rd Edition (1979) pp 466-481. Preferred wax-like matenals useful as solidifying agents in the present wax sticks are descnbed m U.S. Patent 4,126,679, Davy, et al , issued Nov. 21, 1978, herem mcorporated by reference m its entirety. Preferred mixtures of wax-like matenals comprise fatty alcohols contammg carbon chains of from about 14 to about 18 carbon atoms, and alcohols having cham lengths of 20 carbons or longer, wherem the final mixture contams from about 1% to about 3% (by weight) of the longer-cham fatty alcohols. Compositions containing these fatty alcohol mixtures are descnbed m European Patent Specification No. 117,070, May, published Aug. 29, 1984 (mcorporated by reference herem). Also useful herem are biopolymers such as those descnbed m European Application No. 522624, to Dunphy et al., herein incorporated by reference m its entirety. The gel stick embodiments of this mvention preferably contain from about 3% to about 30%, preferably from about 3% to about 10% (by weight), of a solidifying agent. The particular amount of solidifymg agent to be used will depend upon the particular solidifying agent and the liquid base material used, and the desired physical characteristics of the gel stick Solidifying agents useful m the gel stick embodiments of this invention are, in general, surface-active compounds which form networks immobilizing or solidifymg the liquid base matenals into a gel Such solidifying agents include: soaps, such as the sodium and potassium salts of higher fatty acids, i.e., acids having from 12 to 22 carbon atoms; amides of higher fatty acids, higher fatty acid amides of alkylolamines; dibenzaldehyde-monosorb.tol acetals; alkali metal and alkaline earth metal salts of the acetates, propionates and lactates; waxes, such as candehlla and carnauba waxes; and mixtures thereof. Among those solidifying agents preferred for use m the gel stick embodiments of this invention are sodium stearate, sodium palmitate, alummum stearate, aluminum magnesium hydroxy stearate, and mixtures thereof. Gel stick compositions contammg solidifymg agents among those useful herein are descnbed in the following patent documents, all incorporated herein by reference m their entirety: U S. Patent 2,900,306, Slater, issued Aug. 18, 1959; U.S Patent 3,255,082, Barton, issued June 7, 1966; U.S. Patent 4,137,306, Rubino, et al., issued Jan 30, 1979; U.S. Patent 4,154,816, Roehl. et al, issued May 15, 1979; U S Patent 4,226,889, Yuhas, issued Oct. 7, 1980, U S Patent 4,346,079, Roehl, issued Aug. 24, 1982, U S Patent 4,383,988, Teng, et al., issued May 17, 1983; European Patent Specification No 107,330, Luebbe, et al , published May 2, 1984; and U S patent application Ser No 630,790, DiPietro, filed July 13, 1984 Preferred solidifying agents useful in the gel stick embodiments of the present invention are descnbed in European Patent Specification No 24,365 Sampson, et al., published Mar. 4, 1981, incorporated herem by reference in its entirety Also useful herem as solidifymg agents are conventional thickemng agents. Examples of suitable thickeners include, but are not limited to, naturally-occurring polymeric materials such as, locust bean gum, sodium algmate, sodium casemate, egg albumm, gelatm agar, canageenm gum sodium algmate, xanthan gum, qu ce seed extract, tragacanth gum, starch, chemically modified starches and the like, semi-synthetic polymeric matenals such as cellulose ethers (e g. hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxy propylmethyl cellulose), polyvmylpyrrohdone, polyvinylalcohol, guar gum, hydroxypropyl guar gum, soluble starch, catiomc celluloses, cationic guars and the like and synthetic polymenc materials such as carboxyvinyl polymers, polyvmylpyrrohdone, polyvmyl alcohol polyacry c acid polymers, polymethacrylic acid polymers, polyvmyl acetate polymers, polyvinyl chloride polymers, polyvmylidene chlonde polymers and the like. Inorgamc thickeners may also be used such as alumimum silicates, such as, for example, bentomtes, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate. Naturally occunng polymers or biopolymers and their use are further descnbed in European Application No 522624, to Dunphy et al. Additional examples of naturally occurnng polymers or biopolymers can be found in the Cosmetic Bench Reference, pp 1 40-1 42, herem incorporated by reference. Also useful herein are hydrophihc gelling agents such as the acrylic acid/ethyl acrylate copolymers and the carboxyvmyl polymers sold by the B.F. Goodrich Company under the trademark of Carbopol Registered TM resms These resms consist essentially of a colloidally water-soluble polyalkenyl polyether crosslinked polymer of acrylic acid crosslinked with from 0.75% to 2.00% of a crosslinking agent such as polyallyl sucrose or polyallyl pentaerythπtol. Examples include Carbopol 934,Carbopol 940, Carbopol 950, Carbopol 980, Carbopol 951 and Carbopol 981. Carbopol 934 is a water-soluble polymer of acrylic acid crosslinked with about 1% of a polyallyl ether of sucrose havmg an average of about 5.8 allyl groups for each sucrose molecule. Also suitable for use herem are carbomers sold under the Trade Name "Carbopol Ultrez 10, Carbopol ETD2020, Carbopol 1382, Carbopol 1342 and Pemulen TR-1 (CTFA Designation: Acrylates/10-30 Alkyl Acrylate Crosspolymer). Combmation of the above polymers are also useful herein. Other gelling agents suitable for use herein include oleogels such as tπhydroxysteann. Hydrophobically modified celluloses are also suitable for use herem. These celluloses are described in detail in U.S. Patents 4,228,277 and 5,104,646, both of which are herem mcorporated by reference m their entirety. Additional examples of suitable gelling agents or gellants can be found in the Cosmetic Bench Reference, p. 1 27, herein mcorporated by reference. Without being limited by theory, the solidifying agent in combmation with the emollient is believed to act as an occlusive on the skin by forming continuous or discontmuous bi-layer or multi-layer films on the skin. The term "occlusive," as used herein, means a preventmg or obstructing something, in this case, preventing the removal of moisture (via evaporation) and the vitamin B 3 compound (via film bmdmg) from the surface of the skin. Color Certain embodiments of the present invention, preferably lipsticks or lip pamts, contam from 0% to about 90%, preferably from about 1% to about 35%, more preferably from about 1% to about 20% and most preferably from about 5% to about 15%, of color, on an anhydrous pigment weight basis These are usually alummum, barium or calcium salts or lakes Preferably, dyes are present at from about 0.1% to about 4% and pearls from 0% to about 20% Pigments are typically dispersed in emollients for the good dispersion of the pigments when mcorporated into the lip compositions, thus providmg an even distnbution of color. Excellent dispersion of the pigment can be achieved by utilizing association structures, preferably lamellar liquid crystals, as a means of mcorporatmg the color/pigments mto the cosmetic compositions of the present invention A preferred method of incorporating dry pigments comprises the steps of (a) preparmg a mixture consisting essentially of ( 1 ) a polar solvent; and (2) a surfactant selected from the group consisting of amphotenc, cationic, amomc and nomomc surfactants havmg a Krafft point at or below about ambient temperature and mixtures thereof; and (b) stirnng said mixture until association structures form, (c) adding and mixing dry pigments until achieving a homogenous mixture, (d) milling said mixture until uniform particle size is achieved, and (e) addmg and mixing the mixture of (c) to the remaining ingredients until a homogenous mixture is obtamed If the ingredients of the cosmetic composition are bemg processed such that the association structures are bemg formed in situ, the preferred method of mcorporatmg the dry pigments is to slurry them m one or more of the liquid emollient ingredients. Colors/pigments suitable for use herein are all inorganic and organic colors/pigments suitable for use in lipstick compositions. Lakes are either a pigment that is extended or reduced with a solid diluent or an orgamc pigment that is prepared by the precipitation of a water-soluble dye on an adsorptive surface, which usually is alummum hydrate There is uncertainty m some instances as to whether the soluble dye precipitates on the surface of the alummum hydrate to yield a dyed morgamc pigment or whether it merely precipitates in the presence of the substrate. A lake also forms from precipitation of an insoluble salt from an acid or basic dye Calcium and barium lakes are also used herem Lakes suitable for use in the present invention mclude Red 3 Alummum Lake, Red 21 Aluminum Lake, Red 27 Aluminum Lake, Red 28 Aluminum Lake, Red 33 Aluminum Lake, Yellow 5 Alummum Lake, Yellow 6 Alummum Lake, Yellow 10 Alummum Lake, Orange 5 Alummum Lake and Blue 1 Alummum Lake, Red 6 Barium Lake, Red 7 Calcium Lake Other colors and pigments can also be included m the lipsticks, such as dyes and pearls, titamum oxides, Red 6, Red 21, Brown, Russet and Sienna dyes, chalk, talc, iron oxides and titanated micas Perferably, the color component is water-insoluble particulate solids havmg an average particle size diameter of less than about 5 microns, more preferably 2 microns, most preferably 1 micron. Without bemg limited by theory, it is believed that such solid particulates position themselves at the interface of dispersed droplets (i.e., the discontmuous phase) and the contmuous phase to serve as barners, preventmg the coalescence of the dispersed droplets and, hence, improving stabilization A more detailed explanation of this phenomenon is described m S E. Fnberg and Kare Larsson, Food Emulsions, pp. 36- 41, Marcel Dekker, Inc. (1997), herein incorporated by reference in its entirety Dispersants may also be used in conjunction with the colors and pigments of the present mvention. Examples of suitable dispersants mclude, but are not limited to, those described m U.S. Patent 5,688,493, herem incorporated by reference m its entirety Dermatogicallv Acceptable Cosmetic Carrier The composition of the present invention in association with a cosmetically or dermatologically acceptable cosmetic vehicle or earner. Such a earner is compatible with the skm, the nails, the mucous membranes, tissues and the hair and includes any conventionally used cosmeUc or dermatological earner which meets these requirements. Such a carrier is also compatible with the vitamin B 3 compound, that is the earner should not interact with the vitamm B 3 compound. Suitable earners mclude, but are not limited to, solutions, soaps, bodywashes, emulsions, ointments, lipsticks, foundations, mascaras, powders, suspensions, creams, lotions, gels, foams, mousses and the like These carriers facilitate topical application and, in some cases, provide additional therapeutic effects, e g , by moisturizing of the affected skm areas. Dermatologically acceptable cosmetic earners can be readily selected by one of ordinary skill m the art. Other Additives Other optional ingredients which can be present in the cosmetic compositions of the present invention include the flavor oils which were descnbed above, fat soluble vitamins such as vitamm A and E, esters of vitamm A (e.g., acetate, propionate, or palmitate) and of vitamm E (e.g., acetate or sorbate), sunscreens such as octyl methoxycmnamate and butyl methoxydibenzoylmethane, sunblocks such as titanium dioxide and zinc oxide, germicides such as tnclosan, anti-mflammatory agents such as hydrocorhsone, pid matenals such as ceramides and posomes and skm care actives The cosmetic compositions can compnse ingredients conventionally employed in cosmetic compositions such as mascara, foundation or pcare products This includes skin care active ingredients such as pharmaceutically active ingredients Skm care actives ingredients m both water soluble and water insoluble forms can be added to the cosmetic compositions of the present invention These include, but are not limited to vitamin C and its derivatives (e.g., ascorbyl palmitate, ascorbyl phosphate and its salts such as magnesium or sodium), vitamm D, panthenol, retinoic acid, zinc oxide, beta-glycyerhetic acid; chamomile oil; ginko biloba extract; pyroglutamic acid, salts or esters; sodium hyaluronate; 2-hydroxyoctanoιc acid, sulfur; salicylic acid; carboxymethyl cysteme, and mixtures thereof These additives, both fat soluble and water soluble, will normally be present in amounts of less than about 10% by weight, and generally in the range of about 0 01% to about 5%, preferably from about 0.01% to about 3%, most preferably from about 0 1% to about 1%, by weight. Flavor oils such as peppermint oil, orange oil, citrus oil, wintergreen oil can be used along with an alcohol or glycerme. Flavor oils are usually mixed m a solvent such as ethanol to dilute the flavor The flavor oils useful herem can be derived from natural sources or be synthetically prepared. Generally flavor oils are mixtures of ketones, alcohols, fatty acids, esters and terpenes. The term "flavor oil" is generally recognized in the art to be a liquid which is denved from botamcal sources, i.e. leaves, bark, or skm of fruits or vegetables, and which are usually msoluble in water The level of flavor oil used can range from 0% to about 5%, preferable from 0% to about 1% Moisturizers may also be included into the present compositions Preferred moisturizers include pyrro done carboxylic acid, sodium lactate or lactic acid, urea, guamdme, glyceπc acid and its salts (e.g., calcium salt), petrolatum, collagen, α-hydroxy propylglyceryl ether, α-hydroxy acids (e.g., ethylglycohc acid, leucic acid, mandelic acid, glyco c acid), glucosamines, and elastin fibers, D-panthenol, allantom and hyaluronic acid and chondroitm sulfate. Examples of suitable moisturizers can be found in Cosmetic Bench Reference, p 1.30-1 32 (1996), herein incorporated by reference. A prefened optional component is ethyl cellulose (Ethocel) Ethyl cellulose generally is preferred for use at levels of about 5% and more preferably 1% Another prefened optional component is silica Silica is generally prefened for use at levels of from about 1% and about 5% Hypoallergenic compositions can be made from the liquid crystal, wax, oil and colors herem. These compositions should not contam fragrances, flavor oils, lanolin, sunscreens, particularly PABA, or other sensitizers or potential sensitizers and imtants The compositions of the present invention can also be made into long lasting or non-transferable cosmetic compositions. Detailed discussions of such lipsticks are found m Japanese Patent Publication Hei No. 6-199630 and European Patent Application 748622, both of which are herem incorporated by reference in their entirety. Additional optional matenals that can be incorporated m the compositions of the present invention can be found in PCT application WO 97/39733, to Oblong et al. METHODS OF USE The cosmetic compositions of the present invention are ideally suited for use in treating the skm and lips, especially in the form of a lipstick or lip balm for applying to the lips a permanent or semipermanent color, ideally with a gloss or luster fimsh The cosmetic compositions can also be used in treating the skm and or lips with a skin care agent for protection agamst exposure to adverse weather, including the wind and the ram, dry and/or hot environments, environmental pollutants (e.g., ozone, smoke, and the like), or exposure to excessive doses of sunlight The compositions are also useful providmg sun protection, moisturizing and/or conditioning for the hair and skin, improved skin feel, regulating skin texture, reducmg fine lines and wrinkles, reducing oily shine on hair or skm, skin lightening and reducmg skin or hair odor The cosmetic compositions can, accordingly, be applied to the skm and/or lips m the traditional manner with or without a convement holder or applicator to provide a decorative and or protective film thereto. Methods of Determining Solubility of Vitamin B 3 Compounds m Emollients The solubility of the vitamm B 3 compound m the vanous polar and non-polar emollients of the present mvention can be determined as follows- I. Preparation of Samples for Analysis: 1 ) the emollient is placed in pre-weighted vial and the saturated with a vitamin B 3 compound; 2) the vial is shaken and allowed to sit in a bath at 30°C for 1 hour. A small stir bar is used to agitate the contents of the vial. If no precipitation occurs in the vial, then more macmamide is added This was repeated until precipitation occurred The sample is left in the bath for an additional 48 hours to msure saturation; 3) the saturated emollient is drawn mto a syringe; 4) A 0 45 micron filter (Gelman Acrodisc) is fitted on the end the syringe and the emollient is filtered through mto separate pre-weighted vial for analysis; 5) The emollient is analyzed using HPLC to determine the amount of niacmamide therein II. Analysis. Approximately 0.25g of the sample is weighed (sample weight) into a 15mL plastic screw-cap centrifuge tube. The sample is mixed with approximately 3mL of 50/50 v/v methanol chloroform and homogenized by vortex mixing About 7mL of water is then added to extract the vitamm B 3 compound from the methanol/chloroform phase Each sample is mixed by shaking 50 times in a back and forth motion to facilitate transfer of the macmamide from the methanol/chloroform to the water phase. This mixing creates an emulsion at the interface of the two phases. The emulsion can be dissipated by letting the sample stand for several hours or by brief centrifugation (15 seconds) at high speed. Once the two phases have completely separated, a pipette is used to carefully transfer the aqueous phase into a separate, pre-weighted vial. The weight of the aqueous phase is noted (aqueous phase weight). An aliquot of the aqueous phase is transferred to an analysis contamer and analyzed for macmamide by HPLC (Waters 2690 Separations Module coupled with a Waters 996 PDA detector, both supplied by Waters Corporations) Ill.Calculations: The percent vitarmn B 3 compound is determined by taking the vitamin B 3 compound concentration measured by HPLC and multiplying by the dilution factor. The dilution factor is the aqueous phase weight divided by the sample weight EXAMPLES The cosmetic formulations illustrated m Examples I-XI illustrate specific embodiments of the cosmetic compositions of the present invention, but are not mtended to be limiting thereof. Other modifications can be undertaken by the skilled artisan without departmg from the spint and scope of this invention These exemplified embodiments of the cosmetic compositions of the present invention provide unprove the skm penetration of the vitamm B 3 compound as well as improve the improve the stability of the cosmetic composition. All exemplified compositions can be prepared by conventional formulation and mixing techmques. Such formulation and mixing techmques are descnbed m detail m Harry's Cosmeticology, pp. 119-141 and 314-354 (J.B. Wilkinson and R.J. Moore 7 th ed 1982). and Cosmetics Science and Technology, pp. 1-104 and 307-422 (M.S. Balsam and E. Sagann 2 nd ed 1972), both of which are herem incorporated by reference m their entirety Component amounts are listed as weight percents and exclude minor materials such as diluents, fillers, and so forth. The listed formulations, therefore, compnse the listed components and any minor materials associated with such components. Example I A lipstick composition of the present invention is prepared as follows: Ingredient Amount (weight percent) Castor Oil 13.5 Isopropyl palmitate 11.6 Capry c/capnc/isosteaπc/adipic 7 0 tnglycende Lanolm 7 0 Red 21 Alummum Lake 7.0 Candehlla wax 6.6 Propylene glycol mynstyl ether 6 0 acetate Caprylic/capnc tnglycende 5.8 Glycerol 5.0 Water 5.0 Niacmamide 6 0 Titanium dioxide 4.7 Beeswax 4.1 Monoglycende 3.5 Lanolm oil 2.5 Ozokente wax 2.5 Phospho pid (soybean lecithin) 1 0 Polybutene 0.8 Carnauba wax 0 4 The above ingredients are added to a stainless steel vessel equipped with a heatmg source The mgredients are heated to about 85°C and mixed until a homogeneous This mixture is then poured mto a mold and cooled to room temperature The lipstick is applied to the lips to provide color, moisturization and unproved lip feel Example II A lipstick composition of the present invention is prepared as follows- Ingredient Amount (weight percent) Carnauba 1.50 Ozokente 6.00 Candelillia 4.00 Hydrogenated Vegetable Oil 5.00 Acetylated Lanolin 4.00 Isopropyl Isostearate 11.90 Isosteanc Acid 10.00 Propylparaben 0.10 Cetyl Ricinoleate 10.00 Ascorbyl Palmitate 1.00 Sihca L-700 1.00 Polybutene 2.00 Petrolatum 5.50 Association Structure Phase Sucrose Monooleate 1 12.00 Niacmamide 5.00 Glycerine 12.00 Pigment 9.00 ' Ryoto Sugar Ester 0-1690, Mitsubishi-Kagaku Foods Corp The mgredients for the Association Structure Phase, except for the pigments, are mixed until association structures are formed Once the association structures are formed, the pigments are added and the mixture is milled on a three roll mill The mixture is then rmxed with the other ingredients and mixed until a homogeneous mixture (Or, alternatively, the above components are added and mixed together at the same tune.) This mixture is heated to 85°C. The mixture is then deaerated by vacuum and poured mto the appropriate mold. The mixture is cooled to ambient temperature and incorporated mto the appropnate package. The lipstick is applied to the lips to provide color, moisturization and improved lip feel. Example III A lipstick composition of the present invention which is substantially free of castor oil, is prepared as follows: Ingredient Amount (weight percent) Carnauba 1.50 Ozokente 6.00 Candelillia 4.00 Hydrogenated Vegetable Oil 5.00 Isopropyl Palmitate 9.40 Isostearic Acid 7.50 Acetylated Lanolm 4.00 Propylparaben 0.10 Cetyl Ricinoleate 10.00 Ascorbyl Palmitate 1.00 Sihca L-700 1.00 Polybutene 2.00 Petrolatum 5.50 Association Structure Phase Sucrose Monooleate 1 12.00 Niacmamide 10.00 Glycerme 12.00 Pigment 9.00 1 Ryoto Sugar Ester 0-1690, Mitsubishi-Kagaku Foods Corp The composition is prepared as in Example II Example IV A lipstick composition of the present mvention which is substantially free of castor oil, is prepared as follows: Ingredient Amount (weight percent) Carnauba 1.50 Ozokente 5.50 Candelillia 4.00 Hydrogenated Vegetable Oil 8.50 Acetylated Lanolin 4.00 Propylparaben 0.10 Cetyl Ricinoleate 10.00 Ascorbyl Palmitate 1.00 Polybutene 2.00 5.97 Polysiloxane Copolymer Petrolatum 5.97 Anhydrous Lanolm 5.97 Association Structure Phase Lecithm 22.95 Nicotmic acid 2.50 Panthenol 5.04 Glycerine 12.00 Pigment 9.00 1 #1154-141-1, supplied by GE Si cones The composition is prepared as m Example II Example V An antiperspuant gel stick of the present mvention is prepared as follows: Ingredient Amount (weight percent) N-Lauroyl-L-glutarmc acid-di-n-butyl amide 1 4 12-hydroxystearιc acid 2 Propylene Glycol 0.1 Tocopherol mcotmate 2 Light mineral oil 2 23 Dusopropyl Sebacate 3 43 Alummum Zirconium 25 Talc 3 'GP-1 supplied by Ajmomoto, Inc 2 Benol White Mmeral Oil supplied by Witco Chemical Corp. 3 Schercemol DIS supplied by Scher Cherfficals Inc. The gellmg agent and the liquid base material are combined into a vessel equipped with a heat source. Heat the mixture to between about 80°C and about 130°C with stirrmg, until the mixture forms a homogeneous, molten solution Preferably, the homogeneous, molten solution is allowed to cool to a mixing temperature, typically between about 65°C and 120°C (Alternatively, the mixture may simply be heated to the mixing temperature until the mixture forms a homogeneous, molten solution This alternative method, however, typically takes longer than heatmg at high temperatures and then coolmg ) Add the tocopherol mcotmate, propylene glycol, antiperspirant active and other mgredients, such as fragrances and colors, into the homogeneous, molten solution in the above vessel with stimng Allow the mixture to cool until it begms thickening and then pour the mixture into containers allowing them to cool to ambient temperature (Although not preferred, the antiperspirant active may alternatively be added along with the gellmg agent and the liquid base matenal in the first step ) An antiperspirant composition, comprised as above, is applied to the underarm area of a human subject, and reduces the perspuation in the applied area and improves odor in this area Example VI A solid antiperspirant i stick of the present invention is prepared as follows Ingredient Amount (weight percent) Stearyl Alcohol 10 0 Niacinamide 5 Butylene Glycol 0 2 Hydrogenated Castor Oil-mp 8. > degrees C 4 0 Alummum Chlorohydroxide 40 0 Isopar "V"' 45 0 Fragrance 1 0 100 0 '(Isopar "V" Avg Mol Wt 197 B P Range, 255-301 degrees C ) Heat the isoparaffin liquids, the water-insoluble liquid emollients, the surface active agent, and the water- insoluble waxes to a temperature sufficient to form a solution of these matenals, followed by the addition of the active astringent antiperspirant salts and niacinamide with gentle agitation Following addition of the salts, other optional ingredients such as talc may then be added and mixed until a homogenous suspension is formed The suspension is cooled to a temperature above the solidification pomt and is then poured mto suitable contamers An antiperspirant composition, comprised as above, is applied to the underarm area of a human subject, and reduces the perspiration m the applied area and improves odor in this area Example VII A solid antiperspirant stick of the present mvention is prepared as follows Ingredient Amount (weight percent) Steaπc Acid 10 0 Hydrogenated Castor Oil-mp 86 degrees C 4 0 Zirconium Chlorohydroxide 25 0 Talc 10 0 Isopar "M"' 45.0 Propylene Glycol 0.5 Niacmamide 2.0 Dusopropyl Adipate 5 0 Fragrance 1.0 100.0 '(Isopar "M", Avg. Mol. Wt. 191 B.P. Range, 207-260 degrees C ) - In one The composition is prepared and used as Example VI Example VIII An antiperspirant cream of the present mvention is prepared as follows Ingredient Amount (weight percent) cyclomethicone (D5) 43.5 dimethicone (350 cs) 4 0 Cab-O-Sιl HS-5 1 4.0 Microthene FN510 2 6.0 Niacmamide 0.5 Tocopherol mcotmate 0.5 Glycerin 0.1 Natrosol 3 2.0 iso-eicosane 4 13.0 Reach AZ 5 26.7 fragrance 0.8 'Colloidal silica thickemng material, sold by Cabot Corporation. - 2- Low density polyethylene powder, sold by U S.I. Chemicals - 3 Hydroxyethylcellulose, sold by Hercules, Inc. - 4 2, 2, 4, 4, 6, 6, 8, 8-dimethyl-10-methylundecane, obtamed from Permethyl Corporation, Frazier, PA - Zucomum-aluminum-glycme hydroxychlonde complex, particulate antiperspirant active material, sold by Reheis Chemical Company - The cyclomethicone dimethicone, iso-eicosane and perfume are added to a stainless steel mixing vessel. The Cab-O-Sil is then added, followed by the Microthene and Natrosol and, finally, any remaimng ingredients. The composition is thoroughly stirred after addition of each particulate material The composition is then milled, using a Black & Decker Die Grmder (Model 4420, type 4) with a 6.35 cm diameter Cowles dispersing blade at approximately 6,000 rpm, for approximately 5 mmutes. The penetration force value of the milled composition is approximately 300 grams at 25°C. and 50% relative humidity. An antiperspirant cream formulation, compnsed as above, is applied to the underarm area of a human subject, and reduces the perspiration m the applied area and improves odor in this area. Example IX A waterproof mascara of the present mvention is prepared as follows Ingredient Amount (weight percent) Petroleum Distallate ((IBP 345) 51.570 Glycerol Ester of Tall Oil Rosm 10.000 Bentone 38 CG or Type 5 890 (Gellant) Color(Black 34-3068 or Type) 5.000 Alkylated PVP (220 Type) 5.000 Tnhydroxysteann (R Type) 5.000 (Gellant) Magnesium Carbonate 309 5.000 (Filler) Kaolin 2747 2.000 Carnauba Wax, NF 2.000 Propylene Carbonate 1 40 Polyethylene AC-617A 1.000 Propylene Glycol 1 000 Niacmamide 2.000 Phenoxyethanol 0 800 Color( Yellow 34-3170 or Type) 1.600 Propylparaben, NF 0.100 Tenox BHA 0.100 Total 100.000 The above ingredients except colorants, macmamide and gellants/fillers are added mto stainless steel mixing vessel equipped with a heatmg source The mgredients are heated to a temperature of about 90°C and mixed usmg a propeller blade. Once the temperature reaches about 90°C, the mgredients are mixed usmg a dispersator blade at approximately 3500 rpm The pigments are then slowly added dunng the mixing with the dispersator Similarly, the macmamide and gellants/fillers are added with mixing. The mixing is continued with the dispersator until the mixture is homogeneous. The mixture is then forced cooled while mixing with the dispersator at 3500 rpm At about 40°C, mixing is discontinued and the mixture is transfened mto an appropnate storage container The mascara composition is applied to the lashes and/or eyebrows to provide softemng, moisturization and conditioning. Example X A mascara of the present mvention is prepared as follows Ingredient Amount (weight percent) Petroleum Distillate (IBP 345) 49.570 Glycerol Ester of Tall Oil Rosm 10.000 Bentone 38 CG or Type 5 890 (Gellant) Magnesium Carbonate 309 5 000 (Filler) Alkylated PVP (220 Type) 5.000 Tnhydroxysteann (R Type) 5 000 (Gellant) Talc 2755 4 790 (Filler) Kaolin 2747 2.000 (Filler) Carnauba Wax, NF 2.000 Propylene Carbonate 1 940 Propylene Glycol 1.000 Tocopherol mcotmate 4 000 Polyethylene AC-617A 1 000 Phenoxyethanol 0.800 Propylparaben, NF 0.100 Tenox BHA 0.100 Color(Blue 3403516 or Type) 1 810 Total 100.000 The composition is prepared and used as in Example IX Example XI A mascara of the present invention is prepared as follows Petroleum Distillate (IBP 345) 51.670 Glycerol Ester of Tall Oil Rosm 13.000 Bentone 38 CG or Type 5.890 (Gellant) Magnesium Carbonate 309 5.000 (Filler) Trihydroxystsearin (R Type) 5.000 (Gellant) Carnauba Wax, NF 2.000 Kaolin 2747 2.000 (Filler) Propylene Carbonate 1.940 Glycerin 1.000 Niacinamide 5.000 Polyethylene AC-617A 1.000 Phenoxyethanol 0.800 Color 5.500 Tenox BHA 0.100 Propylparaben, NF 0.100 Total 100.000 The composition is prepared and used as in Example IX Example XII A lipstick of the present mvention is prepared as follows. INGREDIENT WT % Polybutene 4.536 Lanolm Oil 18.342 Octoxyglyceryl Behenate 18.342 Stearyl heptanoate 8.856 Jojoba oil 8.856 castor oil 20.78 Butylated hydroxytoluene 0.054 Butylated hydroxyamsole 0.054 Microcrystallme Wax 6.84 Polyethylene 500 6.84 Association Structure Phase Lecithm 0.475 Glycerin 1 Niacmamide 4.5 Cholesterol 0.475 dicetyl phosphate 0.05 In a suitable vessel, the castor oil, polybutene, lanolm oil, octoxyglyceryl behenate, stearyl heptanoate, jojoba oil, butylated hydroxytoluene, butylated hydroxyamsole, microcrystallme wax, polyethylene 500 are added to a vessel equipped with a heat source and heated to a temperature of from about 100-110°C to form a melt The melt is mixed until homogeneous The macmamide, lecithm, glycerin, cholesterol and dicetyl phosphate are rmxed separately to form association structures The association structure mixture is then added to the castor oil contammg mixture and mixed until umform. The mixture is deaerated by vacuum and poured mto the appropnate mold The mixture is cooled to ambient temperature and incorporated into the appropnate package The lipstick is applied to the lips to provide color, moisturization and unproved lip feel Example XIII A water-m-oil topical composition suitable for use as a liquid make-up foundation is prepared from the following ingredients using conventional mixing and formulating techniques such as described below Ingredient Wt. % Part A cyclomethicone 1 15.15 cetyl octanoate 2.00 dimethicone copolyol (DC5225C) 2 20.00 Part B talc 3.38 pigment 10.51 Spheron L-1500 3 0 50 Part C Synthetic Wax Durachem PT-0602 4 1.00 Arachidyl behenate 0.50 Part D cyclomethicone 5 1.00 tnhydroxysteann 0.30 Part E laureth-7 0.50 propyl paraben 0.25 Part G water 17.44 methyl paraben 0.12 propylene glycol 2.00 niacinamide 20.00 glycerin 3.00 sodium chloride 2.00 sodium dehydroacetate 0.30 fragrance 0.05 ; DC245 fluid supplied by Dow Corning 2 Dimethicone copolyol (10%) and DC245 fluid (90%) supplied by Dow corning 3 Spencal silica supplied by Presperse 4 Synthetic wax supplied by Astor Wax Corp 5 DC245 fluid supplied by Dow Corning Combine the mgredients of parts A and B in a suitable contamer. Mix the mgredients usmg a Silverson L4RT mixer equipped w/ a 1 " tubular assembly and a square hole screen for 30 mmutes at 9000 rpm (the contamer can be covered to avoid loss of any volatile or other materials). Heat the resultant mixture to 85-90°C Add ingredients C, mix for 5 mmutes at 2100 rpm usmg a Silverson L4RT mixer equipped w/ a 2" head and a disintegrating screen. The container should be covered to minimize evaporation of cyclomethicone and other volatile or nonvolatile matenals. Cool the resultant mixture to 45- 55°C. Combme the mgredients of part D and mix until a umform slurry is formed. Separately, combme the mgredients E and mix until a umform slurry is formed. Add the resultant slurnes to the mixture of A, B and C (which is at 45-55°C), mix for 5 mmutes at 2100 rpm usmg a Silverson L4RT equipped w/ a 2" head and a disintegrating screen. Cool the resultant mixture to 30° C, then add mgredient fragrance. Mix 5 mmutes at 2100 rpm using a Silverson L4RT equipped w/ a 2" head and a disintegrating screen Combme the ingredients of part G m a suitable contamer and mix. Slowly add the resultant solution to the mixture of A-G. Emulsify this combmation using a Silverson L4RT mixer equipped w/ a 2" head and a disintegrating screen at 2100-5100rpm (rpms will mcrease as the mixture thickens), contmue mixing for 5 mmutes after all of the G mixture is added. Apply the composition to a person's face once per day in an amount of 1-2 mg composition/cm 2 skm for four weeks, to observe a decrease m facial oil, a reduction m oily breakthrough, longer wear of the foundation, and more even coverage as the time penod passes. Other topical compositions suitable for use as a foundation are prepared m the above-descnbed manner usmg pyndoxme, panthenol or pantothemc acid in place of niacmamide and are applied to the face as described above. The foundation is applied to reduce fine lmes and texture of skm as well as reduce oily shine Example XIV A lipstick of the present invention is prepared as follows INGREDIENT WAV% Octyl Palmitate 11.24 Isopropyl Palmitate 4 80 Bentone 38 ' 1.00 Propylene Carbonate 0.33 Cetyl Recmolate 1.00 Dusopropyl Dimearate 6.12 Lanolm Oil 11.60 Ozokente 6.75 Candehlla 5.25 Be Square 175 2 2.00 Granulated Lecithin 2.00 PG-3 Dnsostearate 0.83 Vitamm "E" Acetate 0.05 Propylparaben 0 15 Methylparaben 0.15 Benzoic Acid 0.10 Glycerme 6.00 Niacmamide 5.00 Pigment (35%) slurned in Dusopropyl 25.31 Dimerate Stamers 2.92 1 Quaternιum-18 hectonte, supplied by Rheox 2 Microcrystallme wax, supplied by Petro te Non-treated mica, Mearlmica MMCF, supplied by Mearl In a suitable vessel equipped with a heat source, the cetyl recmolate, dusopropyl dimearate, lanolm oil, ozokerite, candehlla, Be Square 175, granulated lecithin, PG-3 diisostearate, vitarmn E acetate, propylparaben, methylparaben, benzoic acid, glycerme, Mica cf, macmamide are added and heated to a temperature of from about 80-90°C to form a melt. The melt is mixed until homogeneous. In a separate container, the octyl palmitate, isopropyl palmitate, Bentone 38 and propylene carbonate are mixed to form a gel. The gel, pigment slurry and stainers are added to the niacmamide melt and mixed until homogeneous The mixture is deaerated by vacuum and poured into the appropnate mold. The mixture is cooled to ambient temperature and incorporated into the appropnate package. The lipstick is applied to the lips to provide color, moisturization and unproved lip feel. Example XV A lipstick of the present mvention is prepared as follows- Ingredient %WAV Isopropyl Isostearate 12.58 Octyl Palmitate 8.55 Isopropyl palmitate 5.27 Ozokente Wax 5.00 Candehlla Wax 3.00 Paraffin Wax 3.00 Caranauba Wax 2.00 Cetyl Alcohol 2.00 Cetyl Lactate 2.00 Ascorbyl Palmitate 0.50 Propylparaben 0.10 Vitamm E Acetate 0.05 Octyl Methoxycinmmate 7.25 Micronized Tι0 2 m castor oil (25% slurry) 8.00 Niacmamide 5.00 Glycerm 0.10 Mica SVA 1 10.00 Pigment (35%) slurned m Dusopropyl Dimerate 25.60 1 Lauroyl lysme treated mica, Mearlmica SVA, supplied by Mearl The micromzed Ti0 2 m castor oil are ball nulled to the desired particle size. Similarly, the pigments m dusopropyl dimerate are ball milled to the desued particle size. Next, the Tι0 2 and pigments are combmed with the remaimng mgredients m a vessel equipped with a heat source The mixture is heated to a temperature of from about 85-90°C to form a melt. The melt is mixed until homogeneous. The mixture is deaerated by vacuum and poured mto the appropπate mold. The mixture is cooled to ambient temperature and mcorporated mto the appropπate package. The lipstick is applied to the lips to provide color, moisturization and improved lip feel. Example XVI A lipstick of the present invention is prepared as follows: Ingredient %W/W Isopropyl Isostearate 12.58 Octyl Palmitate 8.55 Isopropyl palmitate 5.27 Ozokerite Wax 5.00 Candehlla Wax 3.00 Paraffin Wax 3.00 Caranauba Wax 2.00 Cetyl Alcohol 2.00 Cetyl Lactate 2.00 Ascorbyl Palmitate 0.50 Propylparaben 0.10 Vitamm E Acetate 0.05 Octyl Methoxycinniπ-ate 7.25 Micronized Ti02 in castor oil (25% slurry) 8.00 Niacinamide 5.00 Glycerin 0.10 Mica SVA 1 10.00 Pigment (35%) slurned m Dusopropyl Dimerate 25.60 Lecithm 0.05 Lauroyl lysme treated mica, Mearlmica SVA, supplied by Mearl The micronized Ti0 2 in castor oil are ball milled to the desired particle size Similarly, the pigments in dusopropyl dimerate are ball milled to the desired particle size. Next, the Ti0 2 and pigments are combmed with the remaimng mgredients except lecithm m a vessel equipped with a heat source The mixture is heated to a temperature of from about 85-90°C to form a melt. The melt is mixed until homogeneous. The lecithin is then added with mixing until homogeneous. The mixture is deaerated by vacuum and poured into the appropπate mold. The mixture is cooled to ambient temperature and mcorporated mto the appropπate package. The lipstick is applied to the lips to provide color, moisturization and unproved lip feel. Example XVII The following steps descnbe the preparation of a long lastmg cosmetic emulsion composition A An admixture (Part A) is prepared by combimng in a suitable vessel the following mgredients: INGREDIENT WT. % MQ Resin 1 43.7 PM99A 2 56.3 1 Tπmethylsiloxysilicate available from GE. 2 Isododecane available from Presperse. The admixture is mixed usmg conventional mixing techmques until the MQ Resm is dissolved. Processmg: B An admixture (Part B) is prepared by combimng in a suitable vessel the following mgredients: INGREDIENT WT. %. SE30 Sihcone Gum 1 50.0 PM99A 50.0 ' Available from GE. The admixture is mixed usmg conventional mixing techmques until the SE30 Si cone Gum is dissolved C. A cosmetic emulsion composition contammg Part A and Part B is prepared by combining the following mgredients: D. INGREDIENTS WT Gms Part A 38.67 Part B 20.78 Pigments 10.00 PM99A 1.41 Propylparaben 0.20 Bentone ISD 15.00 Water 6.00 Niacmamide 7.00 Lapomte XLS 1 0.94 1 Hydrous sodium lithium magnesium silicate available from Southern Clay Products In a suitable vessel, the admixture of Part A along with the pigments, propylparaben and PM99A are combmed and mixed usmg a Ultra Tunax T25 homogmzer at about 8,000 φms. for about 10 mmutes or until the cosmetic mixture is umform (taking care not to lgmte the PM99A). The Bentone ISD added to the mixture with mixing at about 8, 000 rpms. until the mixture is umform.. The Lapomte XLS, water, and macmamide are mixed together m a separate vessel and then added to the cosmetic mixture with mixing usmg a Ross homogemzer at about 3,500rpms until umform. The admixture of Part B is added to the cosmetic mixture and mixed mitially at high shear, preferably 1600 rpms., to facilitate dispersion usmg an IKA mixer. Once sufficient dispersion is achieved, the mixer speed is reduced, preferably to about 1,000 rpms., and the cosmetic mixture is allowed to mix until umform. The cosmetic mixture is then poured mto a suitable container and tightly capped for storage, preferably at room temperature. The cosmetic emulsion composition is applied to impart color to the skin, improve skm texture and skm feel.

Claims: What is claimed is: 1. A cosmetic composition, compnsrng: a.) from 0.01% to 50%, by weight, of vitamin B 3 compound; b.) from 0% to 90%, by weight, of an emollient component compnsrng from 0% to 100%, by weight, of an oil liquid at ambient temperature; c ) from 0 01% to 80%, by weight, of a polar solvent; d.) from 0% to 30%, by weight of a surfactant; e.) from 0% to 90%, by weight, of a solidifymg agent; and f.) from 0% to 90%, on an anhydrous basis, of a color wherem the vitamin B 3 compound is added to the composition such that the concentration of the vitamm B 3 compound exceeds the saturation solubility of the vitamm B 3 compound m the composition 2. A cosmetic composition accordmg to Claim 1, wherem the concentration of the vitamm B 3 compound will be at least 150% greater than the saturation solubility of the vitamm B3 compound in the composition at ambient temperature. 3 A cosmetic composition accordmg to Claims 1 or 2, wherem said vitamin B3 compound is macmamide. 4 A cosmetic composition accordmg to any one of the precedmg Claims, wherem said vitarmn B3 compound is substantially uncomplexed. 5. A cosmetic composition accordmg to any one of the precedmg Claims, wherem said polar solvent is selected from the group consistmg of water, glycerme, propylene glycol, butylene glycol, hexylene glycol, alcohol, panthenol and mixtures thereof 6 A cosmetic composition accordmg to any one of the precedmg Claims, wherem said oil compnses from 5% to 90% of the emollient component 7 A cosmetic composition accordmg to any one of the precedmg Claims, wherem said oil is selected such that at least 99% of the types of oils used have solubility parameters which do not differ by more than from 0 1 to 0.8 8. A cosmetic composition according to any one of the precedmg Claims, wherem said cosmetic composition compnses from 2% to 7% candehlla wax, from 2% to 8% ozokente wax, from 2% to 5% paraffin wax, and from 1% to 4% microcrystallme wax. 9. A cosmetic composition according to any one of the precedmg Claims, wherem said emollient component is a polar emollient wherem the solubility (at 30°C) of the vitamm B 3 compound is m the polar emollient is greater than 1.5%. 10 A cosmetic composition, compnsrng: a.) from 0.01% to 50%, by weight, of vitamm B 3 compound; b ) from 0% to 90%, by weight, of an emollient component compnsrng from 0% to 100%, by weight, of an oil liquid at ambient temperature; c.) from 0.01% to 40%, by weight, of a polar emollient, wherem the solubility of the vitamm B 3 compound m the polar emollient is greater than at least 1.5%; d.) from 0% to 90%, by weight, of a solidifymg agent; and e.) from 0% to 90%, on an anhydrous basis, of a color wherem the vitamm B 3 compound is added to the composition such that the concentration of the vitamm B 3 compound exceeds the saturation solubility of the vitamm B 3 compound m the polar solvent.

Inventors: ARMSTRONG MICHAEL GARY JR, SCHERNECK NICHOLE MARIE, TARANTINO DAVID EDMUND, VATTER MICHAEL LEE, ARMSTRONG, MICHAEL, GARY, JR., SCHERNECK, NICHOLE, MARIE, TARANTINO, DAVID, EDMUND, VATTER, MICHAEL, LEE
Applicants: PROCTER & GAMBLE, THE PROCTER & GAMBLE COMPANY
Application year: 2000
Main classification: A61K7
IPC codes: A61K8, A61Q1, A61Q15, A61Q19