AMINOBENZOPHENONES AS INHIBITORS OF IL-1 beta AND TNF- alpha

Abstract: A compound of general formula (I), wherein R1 represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, -CONH2, phenyl, and nitro; R2 represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, -CONH2, phenyl, and nitro; R3 represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, cyano, carboxy, carbamoyl, (C1-C10)alkyl, (C2-C10)olefinic group, (C3-C8)monocyclic hydrocarbon group, (C1-C10)alkoxy, (C1-C10) alkylthio, (C1-C10)alkoxycarbonyl, and phenyl; R4 represents hydrogen, (C1-C6)alkyl, (C2-C6)olefinic group, or (C3-C6)monocyclic hydrocarbon group; R5 represents one or more, same or different substituents selected from the group consisting of hydrogen and R1; X represents oxygen, sulphur, or N-OH; and salts thereof with pharmaceutically acceptable acids, hydrates and solvates, may be used in the prophylaxis or treatment of inflammatory diseases.

Description: AMINOBENZOPHENONES AS INHIBITORS OF IL-1 β AND TNF-CC FIELD OF THE INVENTION This invention relates to a hitherto unknown class of compounds which shows anti-inflammatory effects, to pharmaceutical preparations containing these compounds, to dosage units of such preparations, and to their use in the treatment and prophylaxis of asthma and allergy; inflammatory diseases, such as arthritis, including rheumatoid arthritis and spondyloarthπtis, gout, atherosclerosis, chronic inflammatory bowel disease (Crohn's disease), uveitis, septic shock, and AIDS; proliferative and inflammatory skin disorders, such as psoriasis, atopic dermatitis, and acne; and osteoporosis. BACKGROUND OF THE INVENTION Previously, a series of closely related ammobenzophenones (e.g 4-(2-amιno-4- nιtrophenylamιno)benzophenone) have been described (Hussein, F A er a/, Iraqi J Sci., 22, 54-66 (1981 )). However, there is no description of their uses WO 98/32730 discloses aminobenzophenone inhibitors of interleukin 1 β (IL-1 β) and tumour necrosis factor α (TNF- ) secretion in vitro, said compounds being potentially useful for treatment of inflammatory diseases in which the production of cytokines is involved in the pathogenesis, e.g. asthma, rheumatoid arthritis, psoriasis, contact dermatitis, and atopic dermatitis. Furthermore the compounds of PCT/DK98/00008 were tested in wi/ofor anti- inflammatory properties in the 12-0-tetradecanoylphorbol-13-acetate (TPA) induced muπne chronic skin inflammation model, (De Young, L.M et al., Agents Actions, 26, 335-341 (1989); Carlson, R.P. et al , Agents Actions, 17, 197-204 (1985); Alford, J G. et al., Agents Action, 37, (1992), Stanley, P.L. et al., Skin Pharmacol, 4, 262-271 (1991 )). In this chronic skin inflammation model the compounds had the same potency compared to the reference compound hydrocortisone The purpose of the present invention is to provide further pharmacologically active benzophenone derivatives and related compounds. It has surprisingly been found that novel aminobenzophenone derivatives according to the general formula I are potent inhibitors of interleukin 1 β (IL-1 β) and tumour necrosis factor α (TNF-α) secretion in vitro, making them potentially useful for treatment of inflammatory diseases, in which the secretion and regulation of cytokines or more specifically interleukin 1 β (IL-1 β) and tumour necrosis factor α (TNF-α) are involved in the pathogenesis. The inhibition or down regulation of the cytokines is possibly due to an inhibition of MAP kinases. The preparation of structurally related ammobenzophenones useful as dyes for textiles is disclosed in Man-Made Text India (1987), 30(6), 275-6, Man-Made Text. India (1986), 29(5), 224-30; and Man-Made Text India (1985), 28(11 ), 425, 427-9, 431 ; and a structurally related aminobenzophenone is disclosed in JP 81 -61259 as a reactant in the preparation of fluoran color formers SUMMARY OF THE INVENTION The compounds of the present invention are represented by the general formula I wherein R^ represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, ammo, (C- C Jalkyl, (C2-C 3 )olefιnιc group, (C- j -C Jalkoxy, (C- | -C jalkylthio, (C- | - Cg)alkylamιno, (C- | -C3)alkoxycarbonyl, cyano, -CO H2 , phenyl, or nitro, R2 represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, ammo, (C- | -C3)alkyl, (C2-C3)olefιnιc group, (C- j - C3)alkoxy, (C- j -C jalkylthio, (C- | -Cg)alkylamιno, (C- j -C3)alkoxycarbonyl, cyano, -CONH2 , phenyl, or nitro, R represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, cyano, carboxy, carbamoyl, (C- | -C^ Q )alkyl, (C 2 - C^ Q)olefιnιc group, (C3-Cg)monocyclιc hydrocarbon group, (C 1 -C 1 Q )alkoxy, (C^ -C- | Q)alkylthιo, (C- | - C- ) o)alkoxycarbonyl, or phenyl, R4 represents hydrogen, (C- | -Cg)alkyl, (C2-Cg)olefιnιc group, or (C3-Cg)monocyclιc hydrocarbon group, R5 represents one or more, same or different substituents selected from the group consisting of hydrogen and R^ , X represents oxygen, sulphur, or N-OH, with the proviso that when X represents oxygen then R 1 , R 2 and R 5 together does not represent more than 8 fluorine substituents and with the proviso that the following compounds are not included in formula I 2-Chloro-4'-(2-chlorophenylamιno)benzophenone, 2-Chloro-4'-(phenylamιno)benzophenone, 2-Hydroxy-4'-(phenylamιno)benzophenone, 2-Hydroxy-4'-(4-hydroxyphenylamιno)benzophenone, 2-Hydroxy-4'-(4-methoxyphenylamιno)benzophenone, 2-Hydroxy-4'-(2-hydroxyphenylamιno)benzophenone, 2-Hydroxy-4'-(2-methoxyphenylamιno)benzophenone, 2-Methoxy-4'-(2-methoxyphenylamιno)benzophenone, and 2-Methyl-4'-(4-methoxyphenylamιno)benzophenone. DETAILED DESCRIPTION OF THE INVENTION Preferred embodiments of the invention In compounds of formula I R- | preferably represents a substituent selected from the group consisting of fluoro, chloro, bromo, hydroxy, trifluoromethyl, ammo, (C- | -C2)alkyl, (C2"C3)alkenyl, (C- | -C3)alkoxy, (C- | -C3)alkoxycarbonyl, cyano, and -CONH2; R2 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, trifluoromethyl, am o, (C- | -C )alkyl, (C 2 -C3)alkenyl, and (C- - C 3 )alkoxy. R3 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, trifluoromethyl, (C^ -Cg)alkyl, (C2-Cg)alkenyl, (C- ( -Cg)alkoxy, (C- j -Cg)alkoxycarbonyl, cyano, carboxy, and -CONH2 R 4 represents hydrogen, group; X represents oxygen or sulphur; R5 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, trifluoromethyl, ammo, (C- | -C2)alkyl, (C2"C3)alkenyl, (C- | - C3)alkoxy, (C- | -C3)alkoxycarbonyl, cyano, and -CO H2, More preferably R^ represents a substituent selected from the group consisting of fluoro, chloro, bromo, hydroxy, methyl, and methoxy, R2 represents one or more, same cr different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hyαroxy, methyl, and methoxy; R3 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, methyl, methoxy, cyano, and carboxy; R4 represents hydrogen, methyl, or ethyl; R5 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, trifluoromethyl, methyl, ethyl, and methoxy; X represents oxygen; The phenyl group of R- | , R2, R3, and R5 may optionally be substituted, e.g. with hydroxy; am o; nitro, cyano; halogen, preferably fluoro, chloro, or bromo; methyl; or methoxy A preferred embodiment of the invention is the formula VII: wherein X, R-| , R2, R3, R4, and R5 have the meanings specified above except that R2 does not represent hydrogen Preferred compounds of formula VII are compounds wherein R2 represents a halogen atom, preferably chlorine. Specific compounds of formula I or VII of the invention are: 2-[[3-Chloro-4-(2-methylbenzoyl)]phenylamιno]benzonιtrιle (Compound 101 ), 2-Chloro-2'-methyl-4-(2-methyl-phenylamιno)benzophenone (Compound 102), 2-Chloro-2'-methyl-4-(phenylamιno)benzophenone (Compound 103), 2-Chloro-4-(2-methoxy-phenylamιno)-2'-methylbenzophenone (Compound 104), 2-Chloro-4-(2-fluoro-phenylamιno)-2'-methylbenzophenone (Compound 105), 2-Chloro-4-(2-chloro-phenylamιno)-2'-methylbenzophenone (Compound 106), 4-(2-tert-Butyoxy-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 107), 2-Chloro-4-(2-hydroxy-phenylamιno)-2'-methylbenzophenone (Compound 108), 2-Chloro-4-(3-chloro-phenylamιno)-2'-methylbenzophenone (Compound 109), 2-Chloro-4-(2-[1 ,1 ,1 -tπfluoromethyl]-phenylamιno)-2'-methylbenzophenone (Compound 110), 4-(4-Bromo-2,5-dιfluoro-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 11 1), 2-Chloro-4-(2-ethyl-phenylamιno)-2'-methylbenzophenone (Compound 112), 2-Chloro-4-(3-[1 ,1 ,1 -trιfluoromethyl]phenylamιno)-2'-methylbenzophenone (Compound 113), 2-Chloro-2'-methyl-4-(2-phenyl-phenylamιno)benzophenone (Compound 114), 2-Chloro-2'-methyl-4-(3-phenyl-phenylamιno)benzophenone (Compound 115), 2-Chloro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 116), 2-Chloro-2'-methyl-4-(3-methyl-phenylamιno)benzophenone (Compound 117), 2-Chloro-4-(3-methoxy-phenylamιno)-2'-methylbenzophenone (Compound 1 18), 2-Chloro-4-(4-chloro-phenylamιno)-2'-methylbenzophenone (Compound 119), 2-Chloro-2'-methyl-4-(4-phenyl-phenylamιno)benzophenone (Compound 120), 4-(4-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 121 ), 4-(4-Bromo-3-f luoro-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 122), 4-(2-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 123), 2-Chloro-4-(4-chloro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 124), 2-Chloro-4-(4-chloro-3-fluoro-phenylamιno)-2'-methylbenzophenone (Compound 125), 2-Chloro-4-(3-f luoro-phenylamιno)-2'-methylbenzophenone (Compound 126), 2-Chloro-4-(3,5-dιfluoro-phenylamιno)-2'-methylbenzophenone (Compound 127), 4-(3-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 128), 2-Chloro-4-(3,4-dιfluoro-phenylamιno)-2'-methylbenzophenone (Compound 129), 2-Chloro-4-(5-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 130), 2-Chloro-4-(3-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 131 ), Ethyl 2-[[3-chloro-4-(2-methylbenzoyl)]phenylamιno]benzoate (Compound 132), 2-Chloro-3'-fluoro-4-(4-f luoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 133), 2-[[3-Chloro-4-(2-methylbenzoyl)]phenylamιno]benzoιc acid (Compound 134), 2-Chloro-4-(4-fluoro-2-methyl-Λ/-methyl-phenylamιno)-2'-methylbenzophenone (Compound 135), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2'-methylbenzophenone (Compound 136), 4-(4-Bromo-2-chloro-phenylamιno)- 2-chloro-2'-methylbenzophenone (Compound 137), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-methoxy-2'-methylbenzophenone (Compound 138), 4-(4-Bromo-2-methyl-phenylamιno)- 2,4'-dιchloro-2'-methylbenzophenone (Compound 139), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-fluoro-2'-methylbenzophenone (Compound 140), 4-(4-Bromo-2-methyl-phenylamιno)- 2-fluoro-2'-methylbenzophenone (Compound 141 ), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2',5'-dιmethyl-benzophenone (Compound 142), 2-Chloro-4-(4-cyano-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 143), 4-(4-Bromo-2-methyl-/V-ethyl-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 144), 2-Chloro-4-(4-bromo-2-methyl-phenylamιno)-4'-ethoxy-2'-methylbenzophenone (Compound 145), 2, 3'-Dιchloro-4-(4-bromo-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 146), and salts thereof with pharmaceutically acceptable acids, hydrates and solvates Compounds of formula la wherein X=S and wherein R- | , R2, R3, R4, and R5 have the meanings specified for formula I, and compounds of formula lb wherein X=N-OH and wherein R-| , R2, R3, R4, and R5 have the meanings specified for formula I are also generally preferred la lb Specific compounds of formula la are. 2-[[3-Chloro-4-(2-methyl(thιobenzoyl))]phenylamιno]benzonιtπle (Compound 301 ), 2-Chloro-2'-methyl-4-(2-methyl-phenylamιno)(thιobenzophenone) (Compound 302), 2-Chloro-2'-methyl-4-(phenylamιno)(thιobenzophenone) (Compound 303), 2-Chloro-4-(2-methoxy-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 304), 2-Chloro-4-(2-fluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 305), 2-Chloro-4-(2-chloro-phenyiamιno)-2'-methyl(thιobenzophenone) (Compound 306), 4-(2-terf-Butyoxy-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 307), -Chloro-4-(2-hydroxy-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 308), -Chloro-4-(3-chloro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 309), -Chloro-4-(2-[1 ,1 ,1 -trιfluoromethyl]-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 310), -(4-Bromo-2,5-dιfluoro-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 311 ), -Chloro-4-(2-ethyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 312), -Chloro-4-(3-[1 ,1 ,1 -trιfluoromethyl]phenylamιno)-2'-methyl(thιobenzophenone) (Compound 313), -Chloro-2'-methyl-4-(2-phenyl-phenylamιno)(thιobenzophenone) (Compound 314), -Chloro-2'-methyl-4-(3-phenyl-phenylamιno)(thιobenzophenone) (Compound 315), -Chloro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 316), -Chloro-2'-methyl-4-(3-methyl-phenylamιno)(thιobenzophenone) (Compound 317), -Chloro-4-(3-methoxy-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 318), -Chloro-4-(4-chloro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 319), -Chloro-2'-methyl-4-(4-phenyl-phenylamιno)(thιobenzophenone) (Compound 320), -(4-Bromo-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 321 ), -(4-Bromo-3-fluoro-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 322), -(2-Bromo-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 323), -Chloro-4-(4-chloro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 324), -Chloro-4-(4-chloro-3-fluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 325), -Chloro-4-(3-fluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 326), -Chloro-4-(3,5-dιfluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 327), -(3-Bromo-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 328), -Chloro-4-(3,4-dιfluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 329), 2-Chloro-4-(5-fluoro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 330), 2-Chloro-4-(3-fluoro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 331 ), Ethyl 2-[[3-chloro-4-(2-methyl(thιobenzoyl))]phenylamιno]benzoate (Compound 332), 2-Chloro-3'-fluoro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 333), 2-[[3-Chloro-4-(2-methyl(thιobenzoyl))]phenylamιno]benzoιc acid (Compound 334), 2-Chloro-4-(4-fluoro-2-methyl-Λ/-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 335), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2'-methyl(thιobenzophenone) (Compound 336), 4-(4-Bromo-2-chloro-phenylamιno)- 2-chloro-2'-methyl(thιobenzophenone) (Compound 337), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-methoxy-2'-methyl(thιobenzophenone) (Compound 338), 4-(4-Bromo-2-methyl-phenylamιno)- 2,4'-dιchloro-2'-methyl(thιobenzophenone) (Compound 339), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-fluoro-2'-methyl(thιobenzophenone) (Compound 340), 4-(4-Bromo-2-methyl-phenylamιno)- 2-fluoro-2'-methyl(thιobenzophenone) (Compound 341 ), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro--2',5'-dιmethyl-(thιobenzophenone) (Compound 342), 2-Chloro-4-(4-cyano-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 343), 4-(4-Bromo-2-methyl-Λ/-ethyl-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 344), 2-Chloro-4-(4-bromo-2-methyl-phenylamιno)-4'-ethoxy-2'-methyl(thιobenzophenone) (Compound 345), 2, 3'-Dιchloro-4-(4-bromo-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 346), and salts thereof with pharmaceutically acceptable acids, hydrates and solvates. Specific compounds of formula lb are: 2-[[3-Chloro-4-[(hydroxyιmιno)(2-methylphenyl)methyl]]phenylamιno]benzonιtrιle (Compound 401 ), 2-Chloro-2'-methyl-4-(2-methyl-phenylamιno)benzophenone oxime (Compound 402), 2-Chloro-2'-methyl-4-(phenylamιno)benzophenone oxime (Compound 403), 2-Chloro-4-(2-methoxy-phenylamιno)-2'-methylbenzophenone oxime (Compound 404), 2-Chloro-4-(2-fluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 405), 2-Chloro-4-(2-chloro-phenylamιno)-2'-methylbenzophenone oxime (Compound 406), 4-(2-fert-Butyoxy-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 407), 2-Chloro-4-(2-hydroxy-phenylamιno)-2'-methylbenzophenone oxime (Compound 408), 2-Chloro-4-(3-chloro-phenylamιno)-2'-methylbenzophenone oxime (Compound 409), 2-Chloro-4-(2-[1 ,1 ,1 -trιfluoromethyl]-phenylamιno)-2'-methylbenzophenone oxime (Compound 410), 4-(4-Bromo-2,5-dιfluoro-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 411 ), 2-Chloro-4-(2-ethyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 412), 2-Chloro-4-(3-[1 ,1 ,1 -trιfluoromethyl]phenylamιno)-2'-methylbenzophenone oxime (Compound 413), 2-Chloro-2'-methyl-4-(2-phenyl-phenylamιno)benzophenone oxime (Compound 414), 2-Chloro-2'-methyl-4-(3-phenyl-phenylamιno)benzophenone oxime (Compound 415), 2-Chloro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 416), 2-Chloro-2'-methyl-4-(3-methyl-phenylamιno)benzophenone oxime (Compound 417), 2-Chloro-4-(3-methoxy-phenylamιnc )-2'-methylbenzophenone oxime (Compound 418), 2-Chloro-4-(4-chloro-phenylamιno)-,>'-methylbenzophenone oxime (Compound 419), 2-Chloro-2'-methyl-4-(4-phenyl-phenylamιno)benzophenone oxime (Compound 420), 4-(4-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone oxιme(Compound 421 ), 4-(4-Bromo-3-fluoro-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 422), 4-(2-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 423), 2-Chloro-4-(4-chloro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 424), 2-Chloro-4-(4-chloro-3-fluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 425), 2-Chloro-4-(3-fluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 426), 2-Chloro-4-(3,5-dιfluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 427), 4-(3-Bromo-phenyiamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 428), 2-Chloro-4-(3,4-dιfluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 429), 2-Chloro-4-(5-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 430), 2-Chloro-4-(3-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 431 ), Ethyl 2-[[3-chloro-4-[(hydroxyιmιno)(2-methylphenyl)methyl]]phenylamιno]benzoate (Compound 432), 2-Chloro-3'-fluoro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 433), 2-[[3-Chloro-4-[(hydroxyιmιnoi(2-methylphenyl)methyl]]phenylamιno]benzoιc acid (Compound 434), 2-Chloro-4-(4-fluoro-2-methyl-Λ/-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 435), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2'-methylbenzophenone oxime (Compound 436), 4-(4-Bromo-2-chloro-phenylamιno)- 2-chloro-2'-methylbenzophenone oxime (Compound 437), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-methoxy-2'-methylbenzophenone oxime (Compound 438), 4-(4-Bromo-2-methyl-phenylamιno)- 2,4'-dιchloro-2'-methylbenzophenone oxime (Compound 439), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-fluoro-2'-methylbenzophenone oxime (Compound 440), 4-(4-Bromo-2-methyl-phenylamιno)- 2-fluoro-2'-methylbenzophenone oxime (Compound 441 ), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2',5'-dιmethyl-benzophenone oxime (Compound 442), 2-Chloro-4-(4-cyano-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 443), 4-(4-Bromo-2-methyl-Λ/-ethyl-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 444), 2-Chloro-4-(4-bromo-2-methyl-phenylamιno)-4'-ethoxy-2'-methylbenzophenone oxime (Compound 445), 2, 3'-Dιchloro-4-(4-bromo-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 446), and salts thereof with pharmaceutically acceptable acids, hydrates and solvates The compounds of formulae I, VII, la, and lb can be used in the form of their salts which are formed with pharmaceutically acceptable inorganic or organic acids, such as hydrochloric, hydrobromic and hydroiodic acid, phosphoric acid, sulphuric acid, nitric acid, p-toluenesulphonic acid, methanesulphonic acid, formic acid, acetic acid, propionic acid, citric acid, tartaπc acid, succmic acid, benzoic acid, maleic acid, these examples being considered as non-limiting for the invention As used in the specification, unless specified to the contrary, the following terms have the meaning indicated "Alkyl" refers to any univalent group derived from an alkane by removal of a hydrogen atom from any carbon atom, and includes the subclasses of normal alkyl (π-alkyl), and primary, secondary and tertiary alkyl groups respectively, and having the number of carbon atoms specified, including for example (C- | - C 3 )alkyl, (C- | -C 5 )alkyl, (C 5 )alkyl, (Cg-C 10 )alkyl, (Cg-C 5 )alkyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, and t-butyl Alkane refers to an acyclic branched or unbranched hydrocarbon having the general formula C n H 2n+2 , and therefore consisting entirely of hydrogen atoms and saturated carbon atoms. "Olef ic group" refers to a straight or branched acyclic hydrocarbon having one or more carbon-carbon double bonds of either E or Z stereochemistry where applicable, and having the number of carbon atoms specified. The term includes, for example, (C 2 -Cι 5 )olefιnιc group, preferably a (C 2 -C- | 5 )alkenyl; (C 2 -C3)olefιnιc group, preferably a (C2-C3)alkenyl; vinyl; allyl; 1 - butenyl, 2-butenyl; and 2-methyl-2- propenyl. Olefmic groups having only one carbon-carbon double bond, herein called alkenyl, are preferred. "Alkoxy" refers broadly to a radical of the formula -OR, where R is alkyl as defined above, for example (C- | -C3)alkoxy, (C- | -C2)alkoxy, methoxy, ethoxy, n-propoxy, and the like. "(C- | -C3)alkylthιo" refers broadly to a radical of the formula -SR, where R is alkyl as defined above and includes methylthio, ethylthio, n-propylthio, and 2-propylthιo. "(C- | -Cg)alkylamιno" refers broadly to a radical of the formula -NHR or -NR 2 , where R is alkyl as defined above having from 1 -6 carbon atoms and includes, for example, methylammo, dimethylamino, dι-(n- propyl)amιno, and n-butyl(ethyl)amιno. "(C- | -C3)alkoxycarbonyl" refers broadly to a radical of the formula -COOR, where R is alkyl as defined above and includes methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, and i-propoxycarbonyl. "(C3-C- | )monocyclιc hydrocarbon group" includes the saturated cycloalkanes and unsaturated cyclic olefms, such as cycloalkenes having one endocyc c double bond, and having from 3-10 carbon atoms, and includes, for example, (C3-Cg)cycloalkyl, cyclopropyl, cyclopentyl, cyclohexyl, and cyclooctyl, (C3- C ι n )cycloalkene group, and (C3-Cg)cycloalkene group Specific examples are cycloprop-2-enyl, cyclobut-2-enyl, cyclopent-2-enyl, cyclohex-3-enyl, and cyclonon-4-enyl. "Ammo" means the group -NH2. "Carbamoyl" refers to the group -CONH , -CONHR, and -CONRR' where R and R' represent alkyl as defined above. "Carboxy" refers broadly to a radical of the formula -COOH. "Halogen" means the same or different of fluoro, chloro, bromo, and lodo; fluoro, chloro, and bromo being preferred Pharmacological methods To study the effect of the compound of the present invention in vitro the inhibition of the IL-1 β and TNF- α secretion was measured using the following procedure: Cytokme production was measured in the media from lipopolysacchande (LPS) stimulated peripheral blood mononuclear cells. The mononuclear cells were isolated from human peripheral blood by Lymphoprep® (Nycomed, Norway) fractionation and suspended in RPMI 1640 (growth medium) with foetal calf serum (FCS, 2%), at a concentration of 5 x 10^ cells/ml. The cells were incubated in 24-well tissue culture plates in 1 ml a quots. Test compounds were dissolved in dimethylsulfoxide (DMSO, 10 mM) and were diluted with the medium. Compounds were added to the cells for 30 minutes, then LPS (1 mg/ml final concentration) was added. The plates were incubated for 18 hours, and the concentration of IL-1 β and TNF-α in the medium was determined by enzyme-linked immunosorbent assays. The median inhibitory concentrations (IC^ ) of the compounds were calculated. The results are shown in Table 1. The compounds of the present invention also show similar activities in the ability to inhibit PMN (polymorphonuclear) superoxide secretion which is also indicative of potentially useful anti-inflammatory drugs. The compounds were tested using the following procedure: Human polymorphonuclear (PMN) granulocytes were isolated from human blood by dextran sedimentation, Lymphoprep® fractionation and hypotonic lysis of contaminating erythrocytes. Superoxide anion generation was measured as the superoxide dismutase mhibitable reduction of ferricytochrome C (Madhu, S.B. et al, Inflammation, 16^ 241 , (1992)) The cells were suspended in Hanks' balanced salt solution, and incubated for 10 minutes at 37°C with test compounds. The cells were primed by the addition of TNF-α (3 ng/ml final concentration) for 10 minutes, and then ferricytochrome C, (final concentration 750μg/ml), bovine serum albumin (BSA, final concentration 1 mg/ml) and formyl-methionyl-leucyl-phenylalanine (fMLP, final concentration 10 M) were added for 3 minutes. The cells were chilled on ice, and were spun down. The optical densities in the cell-free supernatant was measured in a spectrophotometer. The median inhibitory concentration (IC^Q) of the compounds was calculated The results are shown in Table 1. Table 1. Inhibition of cytokines and PMN-superoxide production in vitro by compounds of the present invention The median inhibition concentration (IC5 Q , nM) of Comp. No.; IL-1 β TNF-α PMN- superoxide 102 13 4.0 6.3 105 25 4.0 13 109 50 7.9 20 116 32 7.9 3.7 119 40 16 5.0 130 40 6.3 50 131 13 4.0 13 136 100 8.0 100 ref. A) 13 7.1 5 0 ref. a): 4-(2-Amιnophenylamιno)-2-chloro-2'-methylbenzophenone, compound 106 disclosed in WO 98/32730. These results show that the compounds of the present invention are able to inhibit the production of IL- 1 β, TNF-α and PMN-superoxide, and showing a pharmacological activity comparable to a reference compound, thus making them potentially useful in the treatment of inflammatory diseases. It appears from the results shown in Table 1 that some of the compounds of the invention are more selective for one of these inflammatory cytokines than for the other two. This may be an advantage in certain therapeutic situations where a more selective cytokme mihibition is indicated. To study the compounds of the present invention in vivo the 12-0-tetradecanoylphorbol-13-acetate (TPA) induced muπne chronic skin inflammation model can be used (De Young, L.M. et al, Agents Actions, 26, 335-341 (1989); Carlson, R.P. et al, Agents Actions, 17, 197-204 (1985); Alford, J.G. et al, Agents Action, 37, (1992); Stanley, P.L. et al, Skin Pharmacol, 4, 262-271 (1991 )), cf. description of method in WO 98/32730 hereby incorporated by reference. These results show that the compounds of the present invention are of the same potency compared to known reference compounds, e.g. hydrocortisone with its known side effects, whereas the compounds of the present invention are well tolerated and are non-toxic. Some members of the present class of compounds show a very low systemic absorption, thus making them especially useful in the treatment of various dermatological diseases. In general, they may be administered by e.g. oral, intravenous, intranasal, topically or transdermal routes. METHOD OF PREPARATION The compounds of the present invention can be prepared in a number of ways well known to those skilled in the art of organic synthesis. The compounds of the present invention can be synthesised using the methods outlined below, together with methods known in the art of synthetic organic chemistry, or variations thereof as appreciated by those skilled in the art. Preferred methods include, but are not limited to, those described below The novel compounds of formulae I, VII, la, and lb may be prepared using the reactions and techniques described in this section. The reactions are performed in solvents appropriate to the reagents and materials employed and are suitable for the transformations being effected. Also, in the synthetic methods described below, it is to be understood that all proposed reaction conditions, including choice of solvent, reaction atmosphere, reaction temperature, duration of experiment and work-up procedures, are chosen to be conditions of standard for that reaction, which should be readily recognised by one skilled in the art. It is understood by one skilled in the art of organic synthesis that the functionality present on various portions of the educt molecule must be compatible with the reagents and reactions proposed. Not all compounds of formula I falling into a given class may be compatible with some of the reaction conditions required in some of the methods described. Such restrictions to the substituents which are compatible with the reaction conditions will be readily apparent to one skilled in the art and alternate methods can be used. Compounds according to the present invention may be prepared by a process comprising coupling of an amine of the formula III with a bromide, iodide, fluoride, chloride or tnflate with the formula II, as shown in scheme 1 , where R- | , R2, R3, R4, R5, and X are as defined in general formula I, except that any substituents or functional groups which are potentially reactive in the coupling reaction may themselves be protected before the coupling reaction is performed and subsequently removed. The coupling reaction is carried out using any of the methods for the formation of diphenylammes known to one skilled in the art of organic synthesis. The preferred method is the palladium catalysed amination method which comprises coupling of an amine with an arylhalogenide (or aryltπflate) in the presence of a base, a suitable Pd source, and a suitable phosphme ligand in an inert solvent. The palladium compound used in the process is not particularly limited, and as specific examples are palladιum(ll) acetate, palladιum(ll) chloride, palladιum(ll) bromide, dιchlorobιs(trιphenylphosphιne)palladιum(ll), tetrakιs(trιphenylphosphιne)palladιum(0), trιs(dιbenzylιdeneacetone)dιpalladιum(0). The preferred ligands include, but are not limited to, racemic or non-racemic 2,2'-bιs(dιphenylphosphιno)-1 ,1 '-bmaphthyl (hereinafter refered to as BINAP), tπ-o- tolylphosphme, tπ-tert-butylphosphine, 1 ,1 '-bιs(dιphenylphosphιno)-ferrocene, bιs[(2- dιphenylphosphιno)phenyl]ether (DPEphos), 2-dιcyclohexylphosphanyl-2'-dιmethylamιnobιphenyl, 2-(dι- ferf-butylphosphιno)bιphenyl, and 9,9-dιmethyl-4,6-bιs(dιphenylphosphιno)xanthene (Xantphos). The amount of palladium and ligand used in this process is typically in the range 0.1 to 10 % by mole relative to the amount of the aromatic halide (or triflate) used. Especially sodium-tert-butoxide (NaOt-Bu) and caesium carbonate (CS2CO3) have proven to be the best bases in this process, but other bases may be used as well. The reaction is typically performed at elevated temperature (80-120 °C) in inert solvents like 1 ,4- dioxane, toluene, benzene and tetrahydrofurane under an inert atmosphere like argon or nitrogen. Coupling Al L: Br, I, OS0 2 CF 3 , or F and Cl (in special cases) Y:CI, Br, I, OS0 2 CF 3 , OS0 2 CH 3 , or OTs FGI: Functional group interconversion Scheme 1 Compounds according to the present invention in which R 4 is not hydrogen may be prepared by a process comprising coupling of an amine of the formula I (R 4 = H) with an alkylating agent, as shown in scheme 1 , where R. | , R2, R3, R5, and X are as defined in general formula I, except that any substituents or functional group which are potentially reactive in the coupling reaction may themselves be protected before the coupling reaction is performed and subsequently removed. Typically alkylating agents of the general formula R-Y include, but are not limited to, iodides (Y=l), bromides (Y=Br), chlorides (Y=CI) and sulfonates (L=OS0 2 R\ where R' represents methyl, trifluoromethyl or 4-methylphenyl). Compounds according to the present invention may in special cases be prepared by a simple functional group interconversion (FGI), meaning a standard process, known to those skilled in the art of organic synthesis, where a functional group in compounds with the general formula I is transformed into a different functional group in one or more synthetic steps, leading to a new compound with the general formula I. Examples of such processes are, but are not limited to, hydrolysis of an ester to give an acid under basic conditions; deprotection of a methylether to give a phenol by treatment with e.g borontπbromide (BB^); and catalytic hydrogenation of an olefin to give a saturated hydrocarbon. Compounds according to the present invention with the general formula I where X = S may be prepared from the ketone (with the general formula I, C =0) by such an FGI process, by using one of the many thiocarbonylat g reagent, known to those skilled in the art of organic synthesis. Examples of such thiocarbonylatmg reagents include, but are not limited to, phosphorous pentasulfide (P4S1 Q), or Lawesson's reagent (2,4-bιs(4-methoxyphenyl)-1 ,3,2,4-dιthιaphosphetane-2,4-dιsulfιde) or the like Compounds according to the present invention with the general formula I where X = N-OH may be prepared from the ketone (with the general formula I, C =0) by treatment with hydroxylamine, or a protected derivative thereof followed by deprotection, in an appropriate solvent like e g. pyπdine or methanol. Compounds according to the present invention with the general formula III may be prepared by several methods known to those skilled in the art of organic synthesis. One useful sequence is shown in scheme 2. The key step comprising coupling of a bromide (or iodide) with the general formula VI with an acid chloride with the general formula V to afford the benzophenone with the general formula IV This compound IV may then be reduced to the corresponding amine with the general formula III by treatment with standard reducing agents Examples of such reducing agents include, but are not limited to, stannous chloride dihydrate; hydrogen, ammonium formiate, or hydrazine hydrate and a catalytic amount of palladium on carbon. The coupling reaction is done by transforming the bromide (VI) into a reactive organometallic intermediate, e.g by treatment with butyllithium to afford the lithium derivative or by treatment with magnesium to afford the magnesium derivative. VI V Coupling hal: Br, I SCHEME 2 The reactivity of this intermediate is then modulated by transmetalation to e.g. zinc, by treatment with ZnC^, ZnB^, or Zn^. This organozmc compund is then coupled with the acid chloride, with the general formula V, under the influence of a palladιum(O) complex in catalytic amount. Examples of such catalyst include but are not particularly limited to tetrakιs(trιphenylphosphιne)palladιum(0), tetrakιs(tπphenylarsιne)palladιum(0), dιchlorobιs(tπphenylphosphιne)palladιum(ll), or benzylchlorobιs(trιphenylphosphιne)palladιum(ll). As shown on scheme 2 compounds with the general formula IV (X = O) may be transformed by an FGI process to give compounds with the general formula IV (X = S or X = N-OH) as described above This is only to illustrate the flexibility in the synthesis and in general the described sequence of processes is only one of many possible strategies for the synthesis of compound of the present invention That is, it may be more advantageous in some cases to alter the sequence of the processes described above The described sequence of processes is not considered as being limited for the preparation of the compounds of the present invention with the general formula I and alteration of the reaction sequence is an obvious alternative for those skilled in the art of organic synthesis. The present compounds are intended for se in pharmaceutical compositions which are useful in the treatment of the above mentioned diseases The amount required of a compound of formula I, VII, lb and la (hereinafter referred to as the active compound or active ingredient) for therapeutic effect will, of course, vary both with the particular compound, the route of administration and the mammal under treatment A suitable dose of an active compound for systemic treatment is 0 1 to 200 mg/kg bodyweight, the most preferred dosage being 0 2 to 50 mg/kg of mammal bodyweight, administered one or more times daily While it is possible for an active ingredient to be administered alone as the raw chemical, it is preferable to present it as a pharmaceutical formulation. Conveniently, the active ingredient comprises from 0.1% to 100% by weight of the formulation. Conveniently, dosage units of a formulation contain between 0.07 mg and 1 g of the active ingredient For topical administration, the active ingredient preferably comprises from 1% to 20% by weight of the formulation but the active ingredient may comprise as much as 50% w/w Formulations suitable for nasal or buccal administration may comprise 0 1% to 20% w/w. for example about 2% w/w of active ingredient. By the term "dosage unit" is meant a unitary, i.e. a single dose which is capable of being administered to a patient, and which may be readily handled and packed, remaining as a physically and chemically stable unit dose comprising either the active material as such or a mixture of it with solid or liquid pharmaceutical diluents or carriers. The formulations, both for veterinary and human medical use, of the present invention comprise an active ingredient in association with a pharmaceutically acceptable carrier therefore and optionally other therapeutic ιngredιent(s). The carrιer(s) must be "acceptable" in the sense of being compatible with the other ingredients of the formulations and not deleterious to the recipient thereof. The formulations include those in a form suitable for oral, ophthalmic, rectal, parenteral (including subcutaneous, intramuscular and intravenous), transdermal, intra-articular, topical, nasal, or buccal administration The formulations may conveniently be presented in dosage unit form and may be prepared by any of the methods well known in the art of pharmacy All methods include the step of bringing the active ingredient into association with the carrier which constitutes one or more accessory ingredients In general, the formulations are prepared by uniformly and intimately bringing the active ingredient into association with a liquid carrier or a finely divided solid carrier or both, and then, if necessary, shaping the product into the desired formulation. Formulations of the present invention suitable for oral administration may be in the form of discrete units as capsules, sachets, tablets or lozenges, each containing a predetermined amount of the active ingredient; in the form of a powder or granules; in the form of a solution or a suspension in an aqueous liquid or non-aqueous liquid, or in the form of an oil-m-water emulsion or a water-m-oil emulsion The active ingredient may also be administered in the form of a bolus, electuary or paste. Formulations for rectal administration may be in the form of a suppository incorporating the active ingredient and a carrier such as cocoa butter, or in the form of an enema Formulations suitable for parenteral administration conveniently comprise a sterile oily or aqueous preparation of the active ingredient which is preferably isotonic with the blood of the recipient. Formulations suitable for intra-articular administration may be in the form of a sterile aqueous preparation of the active ingredient which may be in microcrystalline form, for example, in the form of an aqueous microcrystalline suspension Liposomal formulations or biodegradable polymer systems may also be used to present the active ingredient for both intra-articular and ophthalmic administration Formulations suitable for topical administration, including eye treatment, include liquid or semi-liquid preparations such as liniments, lotions, gels, applicants, oil-in-water or water-m-oil emulsions such as creams, ointments or pastes; or solutions or suspensions such as drops Formulations suitable for administration to the nose or buccal cavity include powder, self-propelling and spray formulations, such as aerosols and atomizers In addition to the aforementioned ingredients, the formulations of this invention may include one or more additional ingredients. The compositions may further contain other therapeutically active compounds usually applied in the treatment of the above mentioned pathological conditions, for instance glucocorticoids, vitamin D analogues, anti-histamines, platelet activating factor (PAF) antagonists, anticolinergic agents, methyl xanthmes, β-adrenergic agents, COX-2 inhibitors, salicylates, indomethacin, flufenamate, naproxen, timegadine, gold salts, penicillamine, serum cholesterol-reducing agents, retinoids, zinc salts, and salicylazosulfapyπdin (Salazopyπn). The novel compounds of the invention are of value in the human and veterinary practice as systemic and topical therapeutic agents for the treatment and prevention of diseases The novel compounds show anti-acne properties and, i.a , anti-inflammatory and cytokine regulating effects possibly due to MAP kinase inhibition, and are useful in the treatment and prophylaxis of asthma, allergy, arthritis, including rheumatoid arthritis and spondyloarthπtis, gout, atherosclerosis, chronic inflammatory bowel disease (Crohn's disease), proliferative and inflammatory skin disorders, such as psoriasis, atopic dermatitis or acne; uveitis, septic shock, AIDS, and osteoporosis. The invention will now be further described in the following non-limiting general procedures, preparations and examples EXAMPLES General procedures, preparations and Examples Specific examples of compounds of formula I are listed in Table 2. All melting points are uncorrected For 1 H and ' ^C nuclear magnetic resonance (NMR) spectra (300 MHz for 1 H) chemical shift values (δ) (in ppm) are quoted, unless otherwise specified, for deutenochloroform and hexadeuterodimethylsulfoxide solutions relative to internal tetramethylsilane (δ 0.00) or chloroform ( 1 H NMR δ 7.25, 1 3 C NMR δ 76.81 ). The value for a multiplet (m), either defined (doublet (d), triplet (t), quartet (q)) or not at the approximate mid point is given unless a range is quoted (s singlet, b broad). The organic solvents used were anhydrous. The term "chromatography" refers to column chromatography using the flash technique and was performed on silica gel The following abbreviations have been used throughout this specification. BINAP= racemic or non- racemic 2, 2'-bιs(dιphenylphosphιno)-1 ,1 '-bmaphthyl, CDC^deuteπochloroform, DMSO- dg=hexadeuterodιmethylsulfoxιde, DMSO=dιmethylsulfoxιde, EtOAc=ethyl acetate, Et2θ=dιethylether, trιs(dιbenzylιdeneacetone)dιpalladιum(0), THF=tetrahydrofurane, TLC=thιn layer chromatography. The numbering in Table 2 refers to the numbering in the formula below General procedure 1 Coupling of compounds of the general formula II with compounds of the general formula III to give compounds of the general formula I, or a protected derivative thereof. A Schlenk tube was charged with the base (Cs 2 C0 3 or NaOt-Bu, 1.4 mmol), Pd 2 (dba) 3 (0.05 mmol), and BINAP (0.075 mmol). The tube was capped with a rubber septum and flushed with argon for 5 mm, then a solution of a halogenide (1.1 mmol), with the general formula II, and an amine (1.0 mmol), with the general formula III, in 1 ,4-dιoxane or toluene (5.0 ml) was added via cannula The resulting solution was first stirred under argon at room temperature for 15 mm and then at 100 °C for 4-20 h or until the starting materials had disappeared as seen on TLC The reaction mixture was allowed to cool to room temperature. The reaction mixture was poured into a mixture of EtOAc and water. The organic phase was separated, dried (MgS0 4 ), filtered and concentrated in vacuo The residue was purified either by chromatography and/or crystallization to afford the coupled product with the general formula I, or a protected derivative thereof. General procedure 2 Coupling of compounds of the general formula VI with compounds of the general formula V to give compounds of the general formula IV, or a protected derivative thereof. The bromide (80 mmol) with the general formula VI was disssolved in dry THF (65 ml) and cooled with stirring to -78 °C under an atmosphere of argon n-Butyllithium (80 mmol, 1.6 M solution in hexane) was then added dropwise, keeping the internal temperature below -65 °C and stirring the resulting mixture for further 15 m . A THF solution of ZnCI 2 (100 mmol, 1.0 M) was added dropwise and the reaction mixture was allowed to warm to room temperature After 2 h the reaction mixture was cooled to 0 °C, and tetrakιs(trιphenylphosphιne)palladιum(0) (4.0 mmol) was added followed by the dropwise addition of the acid chloride (84 mmol), with the general formula V, in THF. The reaction mixture was allowed to warm to 20 °C and stirred for ca 16 h The resulting yellow solution, was filtered and the filtrate poured into a mixture of EtOAc/water 1 :1 , shaken and separated The aqueous phase was extracted with two more portions of EtOAc. The organic phases were combined, dried (MgS0 4 ), filtered, and concentrated in vacuo to afford the crude product. Further purification was done by flash chromatography and/or crystallization to give the title compound IV, or a protected derivative thereof. General procedure 3 Reduction of compounds of the general formula IV with stannous chloride dihydrate to give compounds of the general formula III, or a protected derivative thereof. A mixture of a compound with the general formula IV (5 mmol) and stannous chloride dihydrate (5.64 g, 25 mmol) in absolute ethanol (50 ml) was heated to 70 °C under argon. After 1 hour, or until the starting material had disappeared as seen on TLC, the solution was allowed to cool to room temperature and then poured into ice/water. The pH was made alkaline by the addition of saturated sodium hydroxide (50 ml) before being extracted with ethyl acetate (3x100 ml). The organic phase was dried (MgS0 4 ), filtered and evaporated to afford the crude product. The crude product was further purified either by crystallization or flash chromatography to yield the title compound or a protected derivative thereof. Preparation 1 2-Chloro-2'-methyl-4-nιtrobenzophenone (Compound 201 ) General procedure. 2 Starting compound VI: 2-Bromotoluene Starting compound V. 2-Chloro-4-nιtro-benzoyl chloride Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCI 3 ): δ 195.1 , 148.9, 145.5, 140.6, 135.0, 133.1 , 132.7, 132 4, 131.9, 130.0, 125.9, 125 4, 121.9, 21.5 Preparation 2: 4-Amιno-2-chloro-2'-methylbenzophenone (Compound 202) General procedure: 3 Starting compound IV: 2-Chloro-2'-methyl-4-nιtrobenzophenone (Compound 201) Purification: Chromatography using EtOAc/pentane 1 :9 followed by 1 :4 as eluant 1 3 C NMR (CDCI 3 ): 6 196.7, 150.5, 139.5, 137.6, 135.1 , 133.9, 131.2, 130.7, 129.5, 127.5, 125.3, 1 16.0, 112.2, 20.3 Preparation 3: 2-Chloro-3'-fluoro-2'-methyl-4-nitrobenzophenone (Compound 203) General procedure: 2 Starting compound VI: 2-Bromo-3-fluorotoluene Starting compound V: 2-Chloro-4-nιtro-benzoyl chloride Purification: Chromatography using EtOAc/pentane 1 :20 as eluant 1 3 C NMR (CDCI3): δ 194.3, 161.8, 149.1 , 144.8, 137.6, 133.0, 130.3, 127.2, 126.9, 126.8, 125.5, 122.0, 119.8, 11.7 Preparation 4: 4-Amιno-2-chloro-3'-fluoro-2'-methylbenzophenone (Compound 204) General procedure: 3 Starting compound IV: 2-Chloro-3'-fluoro-2'-methyl-4-nιtrobenzophenone (Compound 203) Purification: Chromatography using EtOAc/pentane 1 :9 followed by CH2CI2 as eluant 13 C NMR (CDCI3): 6 195.2, 161.5, 150.7, 142.1 , 135.5, 134.2, 127.1 , 126.5, 124.5, 1 17.2, 116.0, 112.2, 11.5 Preparation 5: 2-Chloro-4'-methoxy-2'-methyl-4-nιtrobenzophenone (Compound 205) General procedure: 2 Starting compound VI: 2-Bromo-5-methoxytoluene Starting compound V: 2-Chloro-4-nιtro-benzoyl chloride Purification: Crystallization from a MeOH/cyclohexane 10:1 1 3 C NMR (CDCI3). 6 193.3, 163.3, 148.6, 146.3, 144.3, 135.5, 132.4, 129.6, 127.5, 125.3, 121.9, 118.1 , 110.9, 55.5, 22.4 Preparation 6' 4-Amιno-2-chloro-4'-methoxy-2'-methylbenzophenone (Compound 206) General procedure: 3 Starting compound IV: 2-Chloro-4'-methoxy-2'-methyl-4-nιtrobenzophenone (Compound 205) Purification: Filtered through a short column of silica gel 1 3 C NMR (CDCIg)' 6 195.7, 161.7, 149.6, 141.6, 134.2, 133.3, 132.8, 131.4, 129 1 , 1 17.0, 115.8, 112.4, 110.3, 55.3, 21.3 Preparation 7: 2,4'-Dιchloro-2'-methyl-4-nιtrobenzophenone (Compound 207) General procedure: 2 Starting compound VI: 2-Bromo-5-chlorotoluene Starting compound V. 2-Chloro-4-nιtro-benzoyl chloride Purification: Chromatography using EtOAc/pentane 1 :15 followed by 1 :10 as eluant 13 C NMR (CDCIg)- 6 194.1 , 149.0, 145 0, 142 6, 139.4, 133.5, 133.1 , 132 7, 132.5, 130.1 , 126 1 , 125.5, 122.0, 21.4 Preparation 8: 4-Amιno-2,4'-dιchloro-2'-methylbenzophenone (Compound 208) General procedure: 3 Starting compound IV. 2,4'-Dιchloro-2'-methyl-4-nιtrobenzophenone (Compound 207) 1 3 C NMR (CDCIg). 6 195 4, 150.5, 139.8, 137.9, 136.5, 135.1 , 133 7, 131.2, 130.9, 127.5, 125.6, 115 9, 112.3, 20.2 Preparation 9: 2-Chloro-4'-fluoro-2'-methyl-4-nιtrobenzophenone (Compound 209) General procedure: 2 Starting compound VI: 2-Bromo-5-fluorotoluene Starting compound V: 2-Chloro-4-nιtro-benzoyl chloride Purification: Chromatography using EtOAc/pentane 1 :20 as eluant 1 3 C NMR (CDCI 3 ): δ 193.7, 165.1 , 148.9, 145.3, 144.6, 134.7, 132.6, 131.4, 129.9, 125.5, 122.0, 119.5, 1 13.0, 21.8 Preparation 10: 4-Amιno-2-chloro-4'-fluoro-2'-methylbenzophenone (Compound 210) General procedure: 3 Starting compound IV: 2-Chloro-4'-fluoro-2'-methyl-4-nιtrobenzophenone (Compound 209) Purification: Filtered through a short column of silica gel 1 3 C NMR (CDCI3): 6 195.4, 163.9, 150.3, 141.5, 135.5, 134.9, 133.5, 132.2, 128.0, 1 18.1 , 115.9, 1 12.4, 1 12.3, 20.6 Preparation 11 : 2-Fluoro-4-nιtro-2'-methylbenzophenone (Compound 211 ) General procedure: 2 Starting compound VI: 2-Bromotoluene Starting compound V: 2-Fluoro-4-nιtro-benzoyl chloride Purification: Crystallization from a mixture of MeOH/cyclohexane 6:1 1 3 C NMR (CDCI3): 6 193.1 , 159.9, 150.3, 139.3, 136.4, 133.8, 132.6, 132.1 , 131.7, 130.8, 125.8, 119.4, 112.4, 21.0 Preparation 12: 4-Amιno-2-fluoro-2'-methylbenzophenone (Compound 212) General procedure: 3 Starting compound IV: 2-Fluoro-4-nιtro-2'-methylbenzophenone (Compound 21 1 ) Purification: Filtered through a short column of silica gel 13 C NMR (CDCIg): 6 194.3, 163.8, 153.0, 140.7, 136.1 , 134.0, 130.8, 129.9, 127.9, 125.3, 116.8, 1 10.1 , 101.3, 19.8 Preparation 13: 2-Chloro-2',5'-dιmethyl-4-nιtrobenzophenone (Compound 213) General procedure: 2 Starting compound VI: 2-Bromo-1 ,4-dιmethylbenzene Starting compound V: 2-Chloro-4-nιtro-benzoyl chloride Purification: Filtered through a short column of silica gel 1 3 C NMR (CDCIg): δ 195.3, 148.9, 145.6, 137.4, 135.5, 135.0, 133.9, 132.8, 132.3, 132.2, 130.0, 125.5, 121.9, 21.1 , 20.8 Preparation 14: 4-Amιno-2-chloro-2',5'-dιmethylbenzophenone (Compound 214) General procedure: 3 Starting compound IV: 2-Chloro-2',5'-dιmethyl-4-nιtrobenzophenone (Compound 213) Purification: Filtered through a short column of silica gel 13 C NMR (CDCIg): 5 196.8, 150.2, 139.3, 135.1 , 134.9, 134.5, 133.8, 131.4, 131.1 , 130.0, 128.0, 1 16 0, 112.2, 20.8, 19.9 Preparation 15: 2-Chloro-4'-ethoxy-2'-methyl-4-nιtrobenzophenone (Compound 215) General procedure: 2 Starting compound VI: 2-Bromo-5-ethoxytoluene Starting compound V: 2-Chloro-4-nιtro-benzoyl chloride Purification: Crystallization from a mixture of MeOH/cyclohexane 10:1 1 3 C NMR (CDCIg): 6 193.3, 162.8, 148.5, 146.4, 144.3, 135.5, 132.4, 129.5, 127.3, 125.3, 121.9, 118.5, 111.2, 63.8, 22.5, 14.6 Preparation 16: 4-Amιno-2-chloro-4'-ethoxy-2'-methylbenzophenone (Compound 216) General procedure: 3 Starting compound IV: 2-Chloro-4'-ethoxy-2'-methyl-4-nιtrobenzophenone Purification: Filtered through a short column of silica gel 13 C NMR (CDCIg): 6 195.7, 161.2, 149.6, 141.7, 134.2, 133.4, 132.7, 131.1 , 129.2, 117.5, 1 15 7, 112.4, 110.8, 63.5, 21.4, 14.7 Preparation 17: 2,3'-Dιchloro-2'-methyl-4-nιtrobenzophenone (Compound 217) General procedure: 2 Starting compound VI: 2-Bromo-3-chlorotoluene Starting compound V: 2-Chloro-4-nιtro-benzoyl chloride Purification: Crystallization from a mixture of MeOH/cyclohexane 9:1 1 3 C NMR (CDCIg): 6 194.6, 149.2, 144.5, 138.2, 137.3, 137.0, 133.5, 133.2, 130.7, 129.0, 126.5, 125.7, 122.0, 17.3 Preparation 18: 4-Amιno-2,3'-dιchloro-2'-methylbenzophenone (Compound 218) General procedure: 3 Starting compound IV: 2,3'-Dιchloro-2'-methyl-4-nιtrobenzophenone Purification: Filtered through a short column of silica gel 13 C NMR (CDCIg): δ 195.3, 150.9, 142.4, 135.8, 135.8, 134.8, 134.6, 131.0, 126.8, 126.7, 126.4, 116.2, 112.2, 17.1 Example 1 2-[[3-Chloro-4-(2-methylbenzoyl)]phenylamιno]benzonιtrιle (Compound 101 ) To a solution of 4-amιno-2-chloro-2'-methylbenzophenone (10 mmol) and 2-fluorobenzonιtrιle (10 mmol) in DMSO (25 ml) was added potassium tert-butoxide (2.36 g, 21 mmol). The reaction mixture was stirred at room temperature for 40 hours, diluted with water (300 ml) and extracted with ethyl acetate (3x100 ml). The organic phase was dried (MgS0 4 ), filtered and concentrated in vacuo to afford the crude product. The crude product was further purified by flash chromatography using EtOAc/pentane 1 :9 as eluent to yield the title compcund, which crystallized after tnturation in pentane. 1 3 C NMR (CDCIg): δ 196.4, 144.4, 144.3, 138.6, 134.1 , 133.6, 133.5, 132.7, 131.6, 131.5, 130.3, 125.5, 122.0, 119.7, 117.4, 116.9, 1 16.4, 101.9, 20.7 Exam le 2 2-Chloro-2'-methyl-4-(2-methyl-phenylamιno)benzophenone (Compound 102) General procedure: 1 Starting compound II: 2-Bromotoluene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaOt-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 13 C NMR (CDCIg): δ 196.5, 149.0, 139.4, 138.1 , 137.8, 135.2, 133.7, 132.3, 131.4, 131.2, 130.7, 129.6, 128.4, 127.1 , 125.4, 125.3, 123.8, 115.8, 1 12.2, 20.4, 17.9 Example 3 2-Chloro-2'-methyl-4-(phenylamιno)benzophenone (Compound 103) General procedure: 1 Starting compound II: bromobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaOf-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCIg): δ 196.5, 147.8, 140.2, 139.2, 137.9, 135.0, 133.5, 131.3, 130.8, 129.7, 129.6, 129.2, 125.4, 123.8, 121.0, 1 16.4, 1 12.9, 20.4 Example 4 2-Chloro-4-(2-methoxy-phenylamιno)-2'-methylbenzophenone (Compound 104) General procedure: 1 Starting compound II: 2-Bromoanιsole Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaOt-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 13 C NMR (CDCIg): δ 196.4, 149.9, 147.3, 139.2 137.9, 134.9, 133.4, 131.2, 130.8, 129.7, 129.7, 129.2, 125.4, 123.1 , 120.8, 118.6, 117.0, 113.4, 111.1 , 55.6, 20.4 Example 5 2-Chloro-4-(2-fluoro-phenylamιno)-2'-methylbenzophenone (Compound 105) General procedure: 1 Starting compound II: 1 -Bromo-2-fluorobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: Toluene Base: CS2CO3 Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCI3): 6 196.5, 154.5, 146.7, 138.9, 138.1 , 134.8, 133.2, 131.4, 131 .0, 130.2, 129.9, 128.6, 125.4, 124.6, 124.0, 121.2, 1 17.0, 116.2, 113.6, 20.5 Example 6 2-Chloro-4-(2-chloro-phenylamιno)-2'-methylbenzophenone (Compound 106) General procedure: 1 Starting compound II: 1 -Bromo-2-chlorobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaOf-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCIg): 6 196.4, 146.1 , 138.7, 138.3, 137.5, 134.7, 133.1 , 131.4, 131 .1 , 130.9, 130.2, 130.0, 127.7, 125.4, 124.6, 123.5, 1 19.5, 1 18.0, 114.6, 20.6 Example 7 4-(2-fert-Butoxy-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 107) General procedure: 1 Starting compound II: 2-Bromo-1 -tert-butoxybenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dioxane Base: NaOt-Bu Purification: Chromatography using Et 2 0/pentane 1 :4 as eluant 3 C NMR (CDCI3): 6 196.4, 147.1 , 145.9, 139.1 , 138.0, 135.0, 134.9, 133.5, 131.3, 130.8, 129.7, 129.4, 125.4, 123.5, 123.4, 122.5, 118.8, 116.7, 1 13.3, 80.3, 29.0, 20.5 Example 8 2-Chloro-4-(2-hydroxy-phenylamιno)-2'-methylbenzophenone (Compound 108) A solution of 4-(2-tert-butoxy-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 107) (1.33 g, 3.4 mmol) in a mixture of CH2CI2 (5 ml) and trifluoroethanol (20 ml) was cooled to - 5 °C under argron. Tπfluoroacetic acid (423 mg, 3.7 mmol) was added dropvise and the reaction mixture was allowed to come to room temperature over 1 h. After 23 h at room temperature the reaction mixture was poured into saturated NaHC03 and then extracted with EtOAc and CH 2 Cl2. The organic phases was collected, dried (MgS04), filtered, and concentrated in vacuo to give the crude product. This was further purified by flash chromatography using EtOAc/pentane 1 :4 as eluant. 1 3 C NMR (CDCI3): 6 197.3, 150.2, 149.2, 139.1 , 137.8, 135.1 , 133.6, 131.3, 131.0, 129.7, 128.7, 127.0, 126.5, 125.4, 124.2, 121.0, 116.2, 116.1 , 112.6, 20.4 Example 9 2-Chloro-4-(3-chloro-phenylamιno)-2'-methylbenzophenone (Compound 109) General procedure: 1 Starting compound II: 1 -Bromo-3-chlorobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaOf-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCI3): 6 196.5, 146.6, 141.8, 138.8, 138.1 , 135.3, 134.9, 133.2, 131 4, 131.1 , 130.6, 130.3, 129.9, 125.4, 123.4, 120.1 , 1 18.2, 1 17.3, 113.7, 20.5 Example 10 2-Chloro-4-(2-[1 ,1 ,1 -tπfluoromethyl]-phenylamιno)-2'-methylbenzophenone (Compound 1 10) General procedure: 1 Starting compound II: 1 -Bromo-2-(1 ,1 ,1 -tπfluoromethyl)benzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaOf-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 13 CNMR(CDCI 3 ) 61964, 1466, 1390, 1386, 1383, 1347, 1331, 1330, 1314, 1312, 1310, 1300, 1272, 1254, 1238, 1233, 1223, 1179, 1145,206 Example 11 4-(4-Bromo-2,5-dιfluoro-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 111) General procedure 1 Starting compound II 1-ιodo-4-bromo-2,5-dιfluorobenzene Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaOf-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 13 CNMR(CDCI 3 ) 61964, 1556, 1493, 1445, 1385, 1382, 1346, 1328, 1322, 1316, 1314, 1302, 1255, 1201, 1187, 1151, 1063, 207 Example 12 2-Chloro-4-(2-ethyl-phenylamιno)-2'-methylbenzophenone (Compound 112) General procedure 1 Starting compound II 2-Bromo-ethylbenzene Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaOf-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 13 CNMR(CDCI 3 ) 61964, 1495, 1394,1386, 1378, 1375, 1352, 1337, 1312, 1307, 1295, 1282, 1270, 1259, 1253, 1247, 1156, 1120,244,204, 143 Example 13 2-Chloro-4-(3-[1,1,1-trιfluoromethyl]phenylamιno)-2'-methylbenzophenone (Compound 113) General procedure 1 Starting compound II 1-Bromo-3-(1,1,1-trιfluoromethyl)benzene Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaOf-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 13 CNMR(CDCI 3 ) 61965, 1464, 1412,1387, 1382, 1349, 1332, 1322, 1312, 1312, 1307, 1302 1300, 1255, 1229, 1238, 1198, 1175, 1167, 1137,206 Example 14 2-Chloro-2'-methyl-4-(2-phenyl-phenvlamιno)benzophenone (Compound 114) General procedure: 1 Starting compound II: 2-Bromobιphenyl Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaOf-Bu Purification: Chromatography using EtOAc/pentane 1 :9 repeated by chromatography using C^C /pentane 1 :1 as eluant 13 C NMR (CDCIg): δ 196.4, 148.1 , 139.1 , 138.4, 138.0, 137.2, 135.0, 134.6, 133.5, 131.3, 131.2, 130.8, 129.7, 129.3, 129.2, 128.9, 128.4, 127.8, 125.3, 124.2, 121.6, 116.5, 113.0, 20.5 Example 15 2-Chloro-2'-methyl-4-(3-phenyl-phenylamιno)benzophenone (Compound 115) General procedure: 1 Starting compound II: 3-Bromobιphenyl Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaOf-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCI3): 6 196.5, 147.7, 143.0, 140.7, 140.5, 139.1 , 138.0, 135.1 , 133.5, 131.3, 130.9, 130.0, 129.7, 129.4, 128.9, 127.7, 127.1 , 125.4, 122.7, 1 19.7, 1 16.7, 1 13.0, 20.5 Example 16 2-Chloro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 1 16) General procedure: 1 Starting compound II: 2-Bromo-5-fluorotoluene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: Cs 2 COg Purification: Chromatography using EtOAc/pentane 1 :4 as eluant 1 3 C NMR (CDCIg): 6 196.5, 160.5, 149.6, 139.3, 137.8, 136.3, 135.3, 133.7, 131.2, 130.7, 129.5, 128.2, 127.1 , 125.3, 117.8, 1 15.2, 1 13.8, 1 1 1.6, 20.4, 18.1 Example 17 2-Chloro-2'-methyl-4-(3-methyl-phenylamιno)benzophenone (Compound 117) General procedure: 1 Starting compound II: 3-Bromotoluene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaO-t-Bu Purification: Chromatography using CH2CI 2 /pentane 2:1 as eluant 1 3 C NMR (CDCIg): 6 196.5, 148.0, 140.1 , 139.6, 139.2, 137.9, 135.1 , 133.5, 131.3, 130.8, 129.6, 129.4, 129.0, 125.4, 124.7, 121.8, 118.1 , 116.4, 112.9, 21.5, 20.4 Example 18 2-Chloro-4-(3-methoxy-phenylamιno)-2'-methylbenzophenone (Compound 118) General procedure: 1 Starting compound II: 3-Bromoanιsole Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaO-t-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCIg): 6 196.5, 160.8, 147.5, 141.5, 139.1 , 137.9, 135.0, 133.4, 131 .3, 130.9, 130.4, 129.7, 129.4, 125.4, 116.8, 113.3, 1 13.1 , 108.9, 106.7, 55.3, 20.5 Example 19 2-Chloro-4-(4-chloro-phenylamιno)-2'-methylbenzophenone (Compound 1 19) General procedure: 1 Starting compound II: 1 -Bromo-4-chlorobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaO-t-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant and then trituration in Et2θ/pentane 1 :1 1 3 C NMR (CDCIg): 6 196.5, 147.3, 138.9, 138.0, 135.0, 133 4, 131.4, 131.0, 129.8, 129.7, 128.7, 125.4, 122.1 , 122.0, 116.6, 1 13.2, 20.5 Example 20 2-Chloro-2'-methyl-4-(4-phenyl-phenylamιno)benzophenone (Compound 120) General procedure 1 Starting compound II 4-Bromobιphenyl Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaO-f-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 3 CNMR(CDCI 3 ) 51965, 1475, 1404, 1395, 1391, 1379, 1366, 1351, 1335, 1313, 1309, 1297, 1294, 1288, 1282, 1271, 1267, 1254, 1210, 1166, 1132, 205 Example 21 4-(4-Bromo-phenylamιno)-2-chioro-2'-methylbenzophenone (Compound 121) General procedure 1 Starting compound II 1-lodo-4-bromobenzene Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaO-t-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 13 CNMR(CDCI 3 ) 61965, 1471, 1395, 1389, 1381, 1350,1333, 1326, 1314, 1310,1299, 1298, 1254, 1223, 1168, 1160, 1133, 205 Example 22 4-(4-Bromo-3-fluoro-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 122) General procedure 1 Starting compound II 1-lodo-4-bromo-3-fluorobenzene Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaO-t-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 13 CNMR(CDCI 3 ) 61965, 1596, 1459, 1417, 1386, 1383, 1348, 1341, 1331, 1315, 1312, 1310, 1300, 1255, 1178, 1165, 1142, 1077, 1015,206 Example 23 4-(2-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 123) General procedure 1 Starting compound II 1-lodo-2-bromobenzene Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaO-t-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 13 CNMR(CDCI 3 ) 61964, 1462, 1387, 1382, 1347, 1334, 1331, 1314, 1311, 1309, 1300, 1283, 1254,1240, 1198, 1180, 1153, 1146, 206 Example 24 2-Chloro-4-(4-chloro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 124) General procedure 1 Starting compound II 2-Bromo-5-chlorotoluene Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaO-t-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 13 CNMR(CDCI 3 ) 61965, 1485, 1391, 1379, 1369, 1351, 1342, 1335, 1313, 1312, 1308, 1303, 1297, 1290, 1271, 1254, 1249, 1160, 1124,204, 178 Example 25 2-Chloro-4-(4-chloro-3-fluoro-phenylamιno)-2'-methylbenzophenone (Compound 125) General procedure 1 Starting compound II 1-Bromo-4-chloro-3-fluorobenzene Starting compound III 4-Amιno-2-chloro-2'-methylbenzophenone Solvent 1,4-Dιoxane Base NaO-f-Bu Purification Chromatography using EtOAc/pentane 19 as eluant 13 CNMR(CDCI 3 ) 61966, 1586, 1461, 1409, 1386, 1382, 1348, 1331, 1315, 1312, 1308,1300, 1255,1176,1162,1140,1080,206 Example 26 2-Chloro-4-(3-fluoro-phenylamιno)-. '-methylbenzophenone (Compound 126) General procedure: 1 Starting compound II: 1 -Bromo-3-fluorobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaO-t-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCI 3 ): 6 196.6, 163.6, 146.6, 142.3, 138.8, 138.1 , 134.9, 133.2, 131.4, 131.1 , 130.8, 130.3, 129.9, 125.4, 117.4, 115.5, 1 13.8, 110.0, 107.0, 20.5 Example 27 2-Chloro-4-(3,5-dιfluoro-phenylamιno)-2'-methylbenzophenone (Compound 127) General procedure: 1 Starting compound II: 1 -Bromo-3,5-dιfluorobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dioxane Base: NaO-t-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 3 C NMR (CDCI3): δ 196.6, 164.0, 163.8, 145.4, 143.5, 138.4, 134.6, 132.9, 131.5, 131.4, 130.1 , 125.5, 118.5, 114.9, 101.7, 101.7, 97.9, 20.6 Example 28 4-(3-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 128) General procedure: 1 Starting compound II: 1 -lodo-3-bromobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaO-f-Bu Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCI3): 6 196.5, 146.6, 142.0, 138.8, 138.1 , 134.9, 133.3, 131.4, 131 .1 , 130.9, 130.3, 129.9, 126.3, 125.4, 123.2, 123.1 , 1 18.7, 1 17.3, 1 13.7, 20.5 Example 29 2-Chloro-4-(3,4-dιfluoro-phenylamιno)-2'-methylbenzophenone (Compound 129) General procedure: 1 Starting compound II: 1-Bromo-3,4-dιfluorobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaO-t-Bu Purification: Chromatography using C^C^/pentane 2:1 as eluant 13 C NMR (CDCIg): 6196.5, 147.2, 138.8,138.1, 135.0, 133.3, 131.4, 131.1, 130.1, 129.9, 1254, 118.2, 117.9, 117.1, 116.6, 113.1, 110.6,20.5 Example 30 2-Chloro-4-(5-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 130) General procedure: 1 Starting compound II: 2-Bromo-4-fluorotoluene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaO-t-Bu Purification: Chromatography using Et2θ/pentane 1 :4 as eluant 13 C NMR (CDCI 3 ): δ 196.5, 161.6, 147.6, 139.7, 139.0, 138.0, 135.0, 133.4, 132.1, 131.3, 131.0, 129.8, 129.7,126.2, 125.4, 116.9, 113.2, 111.1, 108.8,20.5, 17.2 Example 31 2-Chloro-4-(3-fluoro-2-methyl-phenylamιno)-2'-methyibenzophenone (Compound 131) General procedure: 1 Starting compound II: 2-Bromo-6-fluorotoluene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: NaO-t-Bu Purification: Chromatography using Ei2θ/pentane 1 :2 as eluant 13 C NMR (CDCIg): 6196.5, 162.0, 148.3, 140.1, 139.1, 138.0, 135.0, 133.4, 131.3, 130.9, 129.7, 129.3, 127.2, 125.4, 119.3, 118.6, 116.4, 112.8, 111.7,20.5,9.6 Example 32 Ethyl 2-[[3-chioro-4-(2-methylbenzoyl)]phenylamιno]benzoate (Compound 132) General procedure: 1 Starting compound II: Ethyl 2-bromobenzoate Starting compound lll:4-Amιno-2-chloro-2'-methylbenzophenone Solvent: Toluene Base: CS2CO3 Purification: Chromatography using EtOAc/pentane 1 :50 as eluant 1 3 C NMR (CDCI3): δ 196.5, 168.3, 145.1 , 144.9, 138.6, 138.4, 134.4, 134.0, 132.7, 131.8, 131.5, 131.2, 130.1 , 125.4, 120.4, 119.6, 117.0, 116.0, 114.8, 61.1 , 20.6, 14.3 Example 33 2-Chloro-3'-fluoro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 133) General procedure: 1 Starting compound II: 2-Bromo-5-fluorotoluene Starting compound III: 4-Amιno-2-chloro-3'-fluoro-2'-methylbenzophenone Solvent: Toluene Base: CS2CO3 Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCI3): δ 195.0, 161.5, 160.7, 150.1 , 142.1 , 136.5, 135.7, 134.1 , 133.6, 127.4, 126.5, 124.5, 124.5, 117.9, 117.2, 1 15.2, 1 13.9, 111.5, 18.1 , 11.5 Example 34 2-[[3-Chloro-4-(2-methylbenzoyl)]phenylamιno]benzoιc acid (Compound 134) A solution of 50 mg Ethyl 2-[[3-chloro-4-(2-methylbenzoyl)Jphenylamιno]benzoate (Compound 132) in methanol (2.0 ml) was added aqueous NaOH (2N, 0.5 ml) and then refluxed for 1 h. The reaction mixture was made slightly acidic with aqueous HCI (1 N) and then extracted with EtOAc (3 * 10 ml). The organic phase was washed with water, brine, then dried (MgS0 4 ), filtered, and concentrated in vacuo to afford the pure title compound. 1 3 C NMR (CDCI3). 5 196.6, 173.2, 146.0, 144.5, 138.6, 138.3, 135.3, 134.3, 132.9, 132.6, 132.5, 131.6, 131.4, 130.3, 125.5, 121.3, 119.7, 1 17.8, 115.8, 1 12.9, 20.7 Example 35 2-Chloro-4-(4-fluoro-2-methyl-Λ/-methyl-phenylamιno)-2'-methylbenzophenone (Compound 135) A solution of 2-chloro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 1 16)(105 mg) in Λ/-methyl-2-pyrolιdιnone (2.0 ml) was added sodium hydride (14 mg) in one portion under stirring. After 10 m at 0 °C methyl iodide (47 mg ) was added and the reaction mixture was stirred for 4 hours at room temperature followed by 18 hours at 100 °C. The reaction mixture was poured into water and extracted with EtOAc. The organic phases were separated, dried (MgS04), filtered and concentrated in vacuo. The residue was purified by chromatography using a mixture of diethylether/pentane 1 :4 as eluant to yield the title compound. 1 3 C NMR (CDCIg): δ 196.2, 161.2, 151.7, 140.3, 139.5, 138.7, 137.2, 135.1 , 133.5, 130.8, 130.2, 129.7, 129.0, 125.8, 125.0, 118.0, 1 14.5, 113.3, 109.6, 38.9, 20.0, 17.5 Example 36 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2'-methylbenzophenone (Compound 136) General procedure: 1 Starting compound II: 5-Bromo-2-ιodotoluene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: Toluene Base: CS2CO3 Purification: Chromatography using Et2θ/pentane 1 :3 followed by 1 :2 as eluant 1 3 C NMR (CDCI3): 6 196.6, 148.5, 139.1 , 137.8, 137.5, 135.1 , 134.5, 134.0, 133.6, 131 .2, 130.8, 130.0, 129.6, 128.7, 125.4, 125.1 , 1 17.9, 1 16.0, 1 12.4, 20.4, 17.8 Example 37 4-(4-Bromo-2-chloro-phenylamιno)- 2-chloro-2'-methylbenzophenone (Compound 137) General procedure: 1 Starting compound II: 4-bromo-2-chloro-1 -ιodobenzene Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: 1 ,4-Dιoxane Base: CS2CO3 Purification: Chromatography using EtOAc/pentane 1 :9 as eluant 1 3 C NMR (CDCI3): 6 196.4, 145.3, 138.4, 138.4, 137.0, 134.6, 132.9, 132.6, 131.6, 131.5, 131 .3, 130.7, 130.1 , 125.4, 125.0, 120.0, 1 18.5, 1 15 1 , 1 14.4, 20.6 Example 38 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-methoxy-2'-methylbenzophenone (Compound 138) General procedure: 1 Starting compound II: 5-Bromo-2-ιodotoluene Starting compound III: 4-Amιno-2-chloro-4'-methoxy-2'-methylbenzophenone Solvent: Toluene Base: Cs 2 C0 3 Purification: Chromatography using EtOAc/pentane 1 :4 as eluant 1 3 C NMR (CDCI 3 ): δ 195.5, 161.9, 147.5, 141.9, 137.8, 134.2, 134.0, 133.9, 133.6, 132.4, 131.0, 130.5, 130.0, 124.4, 117.5, 117.1 , 116.1 , 112.9, 1 10.4, 55.3, 21.5, 17.8 Example 39 4-(4-Bromo-2-methyl-phenylamιno)- 2,4'-dιchloro-2'-methylbenzophenone (Compound 139) General procedure: 1 Starting compound II: 5-Bromo-2-ιodotoluene Starting compound III: 4-Amιno-2,4'-dιchloro-2'-methylbenzophenone Solvent: Toluene Base: Cs 2 C0 3 Purification: Chromatography using EtOAc/pentane 1 :3 as eluant 1 3 C NMR (CDCI3): 6 195.3, 148.6, 140.0, 137.6, 137.3, 136.7, 135.1 , 134.5, 134.1 , 133.4, 131.3, 131.0, 130.1 , 128.6, 125.6, 125.1 , 1 18.1 , 1 16.0, 112.6, 20.3, 17.8 Example 40 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-fluoro-2'-methylbenzophenone (Compound 140) General procedure: 1 Starting compound II: 5-Bromo-2-ιodotoluene Starting compound III: 4-Amιno-2-chloro-4'-fluoro-2'-methylbenzophenone Solvent: Toluene Base: CS2CO3 Purification: Chromatography using EtOAc/pentane 1 :6 as eluant 1 3 C NMR (CDCI3): 6 195.3, 164.0, 148.4, 141.7, 137 4, 135.2, 134.9, 134.4, 134.1 , 133.2, 132.4, 130.1 , 129.1 , 125.0, 1 18.2, 1 18.0, 1 16.0, 112.7, 112.3, 20.7, 17.8 Example 41 4-(4-Bromo-2-methyl-phenylamιno)- 2-fluoro-2'-methylbenzophenone (Compound 141 ) General procedure: 1 Starting compound II: 5-Bromo-2-ιodotoluene Starting compound III: 4-Amιno-2-fluoro-2'-methylbenzophenone Solvent: Toluene Base: Cs 2 C0 3 Purification: Chromatography using EtOAc/pentane 1 :6 as eluant 1 3 C NMR (CDCIg): 6 194.2, 163.7, 151.0, 140.4, 137.1 , 136.3, 134.9, 134.1 , 133.9, 130.9, 130.1 , 128.1 , 125.7, 125.3, 1 18.5, 1 17.8, 110.2, 101.1 , 19.9, 17.7 Example 42 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2',5'-dιmethyl-benzophenone (Compound 142) General procedure: 1 Starting compound II: 5-Bromo-2-ιodotoluene Starting compound III: 4-Amιno-2-chloro-2',5'-dιmethyl-benzophenone Solvent: Toluene Base: Cs 2 C0 3 Purification: Chromatography using EtOAc/pentane 1 :8 as eluant 1 3 C NMR (CDCI3): 6 196.6, 148.2, 139.0, 137.5, 135.1 , 134.9, 134.7, 134.2, 134.1 , 133.5, 131 .6, 131.2, 130.1 , 129.2, 124.8, 117.8, 116.2, 112.6, 20.8, 19.9, 17.8 Example 43 2-Chloro-4-(4-cyano-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 143) General procedure: 1 Starting compound II: 4-Bromo-3-methylbenzonιtrιle Starting compound III: 4-Amιno-2-chloro-2'-methylbenzophenone Solvent: Toluene Base: CS2CO3 Purification: Chromatography using EtOAc/pentane 1 :3 as eluant 13 C NMR (CDCI3): 5 196.4, 145.0, 143.8, 138.5, 138.2, 134.8, 134.5, 132.8, 132.2, 131.6, 131 .4, 131.4, 130.2, 128.1 , 125.5, 1 19.5, 119.2, 117.4, 1 16.0, 105.1 , 20.7, 17.7 Example 44 4-(4-Bromo-2-methyl-Λ/-ethyl-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 144) A solution of 4-(4-bromo-2-methyl-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 136)(1 10 mg) in dry tetrahydrofurane (2.0 ml) was added sodium hydride (19 mg) in one portion under stirring. After 10 m at room temperature ethyl iodide (124 mg ) was added and the reaction mixture was stirred for 18 hours under reflux, then poured into water and extracted with EtOAc The organic phases were separated, dried (MgS0 4 ), filtered and concentrated in vacuo. The residue was purified by chromatography using a mixture of EtOAc/pentane 1 :8 as eluant to yield the title compound as an oil. 1 3 C NMR (CDCIg): 5 196.3, 150.8, 142.0, 139.7, 139.2, 137.4, 135.5, 134.7, 133.9, 131.1 , 131.0, 130.4, 129.2, 126.0, 125.2, 121.2, 1 13.7, 109.9, 46.0, 20.2, 17.7,12.4 Example 45 2-Chloro-4-(4-bromo-2-methyl-phenylamιno)-4'-ethoxy-2'-methylbenzophenone (Compound 145) General procedure: 1 Starting compound II: 5-Bromo-2-ιodotoluene Starting compound III: 4-Amιno-2-chloro-4'-ethoxy-2'-methylbenzophenone Solvent: Toluene Base: Cs2CO Purification: Chromatography using EtOAc/pentane 1 :4 as eluant 1 3 C NMR (CDCIg): 6 195.5, 161.4, 147.5, 142.0, 137.9, 134.2, 134.0, 133.8, 133.7, 132.4, 130.7, 130.6, 130.0, 124.4, 1 17.6, 1 17.4, 116.1 , 1 13.0, 1 10.8, 63.5, 21.5, 17.8, 14.7 Example 46 2,3'-Dιchloro-4-(4-bromo-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 146) General procedure: 1 Starting compound II: 5-Bromo-2-ιodotoluene Starting compound III: 4-Amιno-2,3'-dιchloro-2'-methylbenzophenone Solvent: Toluene Base: Cs 2 COg Purification: Chromatography using acetone/toluene 1 :99 as eluant 1 3 C NMR (CDCIg): 6 195.2, 149.1 , 142.1 , 137.1 , 135.9, 135.8, 134.9, 134.7, 134.3, 134.1 , 131 .1 , 130.1 , 127.7, 126.8, 126.4, 125.5, 118.4, 1 16 1 , 112.3, 17.8, 17.1 Example 47 Tablet containing compound 102 Compound 102 (active substance) 50 mg Lactose 125 mg Starch 12 mg Methyl cellulose 2 mg Sodium carboxymethyl cellulose 10 mg Magnesium stearate 1 mg The active substance, lactose and starch are mixed to a homogeneous state in a suitable mixer and moistened with a 5 per cent aqueous solution of methyl cellulose 15 cps The mixing is continued until granules are formed If necessary, the wet granulation is passed through a suitable screen and dried to a water content of less than 1 % in a suitable drier, e g fluid bed or drying oven The dried granules are passed through a 1 mm screen and mixed to a homogeneous state with sodium carboxymethyl cellulose Magnesium stearate is added, and the mixing is continued for a short period of time Tablets with a weight of 200 mg are produced from the granulation by means of a suitable tablettmg machine Example 48 Formulation for injection containing compound 102 Compound 102 (active substance) 1 % Sodium chloride q s Ethanol 10% Water for injection to make 100% The active substance is dissolved in ethanol (10%) then water for injection made isotonic with sodium chloride is added to make 100% The mixture is filled into ampoules and sterilized Example 49 Cream formulation containing compound 102 Compound 102 (10 g) was dissolved in Octyldodecyl myπstate (250g) to form Part A Methylparaben (1 g) and propylparaben (0 2 g) were dissolved in phenoxyethanol (6 g) and mixed with a 0 025 M Phosphate buffer pH = 7 5 (632,8 g) to form Part B Cetostearyl alcohol (50 g) and ARLACEL 165® (50 g) was melted in a vessel at 70° to 80 °C Part A was added and heated to 60-70°C The aqueous phase was likewise heated to 60-70 °C and slowly added to the melted oil phase under high speed stirring The homogenized components were cooled to room temperature

Claims: Claims 1. A compound of the general formula I wherein R- | represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, ammo, (C- j -CgJalkyl, (C2-C3)olefιnιc group, (C- | -C3)alkoxy, (C- j -C3)alkylthιo, (C- | - Cg)alkylamιno, (C- | -C3)alkoxycarbonyl, cyano, -CONH2 , phenyl, and nitro, R2 represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, ammo, (C- | -C3)alkyl, (C2-C3)olefιnιc group, (Cγ C3)alkoxy, (C- j -C β jalkylthio, (C- | -Cg)alkylamιno, (C- | -C3)alkoxycarbonyl, cyano, -CONH2 , phenyl, and nitro; Rg represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, cyano, carboxy, carbamoyl, (C- j -C- j jalkyl, (C 2 - C- | o)olefιnιc group, (Cg-Cg)monocyclιc hydrocarbon group, (C- | -C- | Q)alkoxy, (C- | -C- j Q )alkylthιo, (C- | - C- ) Q)alkoxycarbonyl, and phenyl, R4 represents hydrogen, (C- j -Cg)alkyl, (C2-Cg)olefιnιc group, or (Cg-Cg)monocyclιc hydrocarbon group; R5 represents one or more, same or different substituents selected from the group consisting of hydrogen and R- | ; X represents oxygen, sulphur, or N-OH; and salts thereof with pharmaceutically acceptable acids, hydrates and solvates, with the proviso that when X represents oxygen then R^ , R2 and R5 together does not represent more than 8 fluorine substituents and with the proviso that the following compounds are not included in formula I. 2-Chloro-4'-(2-chlorophenylamιno)benzophenone, 2-Chloro-4'-(phenylamιno)benzophenone, 2-Hydroxy-4'-(phenylamιno)benzophenone, 2-Hydroxy-4'-(4-hydroxyphenylamιno)benzophenone, 2-Hydroxy-4'-(4-methoxyphenylamιno)benzophenone, 2-Hydroxy-4'-(2-hydroxyphenylamιno)benzophenone, 2-Hydroxy-4'-(2-methoxyphenylamιno)benzophenone, 2-Methoxy-4'-(2-methoxyphenylamιno)benzophenone, and 2-Methyl-4'-(4-methoxyphenylamιno)benzophenone. 2. A compound according to claim 1 wherein R- | represents a substituent selected from the group consisting of fluoro, chloro, bromo, hydroxy, trifluoromethyl, ammo, (C- j -C2)alkyl, (C2-C )alkenyl, (C | -Cg)alkoxy, (C^ -Cg)alkoxycarbonyl, cyano, and -CONH2- 3. A compound according to any one of the preceding claims wherein R2 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, trifluoromethyl, ammo, (C- | -Cg)alkyl, (C2-Cg)alkenyl, and (C- | -Cg)alkoxy 4. A compound according to any one of the preceding claims wherein Rg represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, trifluoromethyl, (C- | -Cg)alkyl, (C 2 -C 6 )alkenyl, (C- | -Cg)alkoxy, (C- | -Cg)alkoxycarbonyl, cyano, carboxy, and -CONH2. 5. A compound according to any one of the preceding claims wherein R4 represents hydrogen, (C- | - C )alkyl, or (C 2 -C4)olefιnιc group. 6. A compound according to any one of the preceding claims wherein X represents oxygen or sulphur 7. A compound according to any one of the preceding claims wherein R5 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, trifluoromethyl, ammo, (C- | -C2)alkyl, (C 2 -Cg)alkenyl, (C- | -Cg)alkoxy, (C- | - Cg)alkoxycarbonyl, cyano, and -CONH2- 8. A compound according to any one of the preceding claims wherein R- | represents a substituent selected from the group consisting of fluoro, chloro, bromo, hydroxy, methyl, and methoxy. 9. A compound according to any one of the preceding claims wherein R2 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, methyl, and methoxy. 10. A compound according to any one of the preceding claims wherein Rg represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, methyl, methoxy, cyano, and carboxy. 11. A compound according to any one of the preceding claims wherein R4 represents hydrogen, methyl, or ethyl. 12. A compound according to any one of the preceding claims wherein R5 represents one or more, same or different substituents selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, trifluoromethyl, methyl, ethyl, and methoxy. 13. A compound according to any one of the preceding claims wherein X represents oxygen. 14. A compound according to any one of the preceding claims characterised in that when at least one of R-j , R2, R3, and R5 represents a phenyl group said group is optionally substituted with a substituent selected from the group consisting of hydroxy, ammo, nitro, cyano, halogen, methyl, and methoxy 15 A compound according to the preceding claims wherein said halogen is selected from the group consisting of fluoro, chloro, and bromo. 16 A compound of the general formula VII: wherein X, R-| , R2, R3, R4, and R5 have the meanings specified in claim 1 with the proviso that R2 does not represent hydrogen, and salts thereof with pharmaceutically acceptable acids, hydrates and solvates. 17. A compound according to the preceding claim wherein R2 represents a halogen atom 18. A compound according to the preceding claim wherein R2 represents chlorine 19. A compound according to claim 1 or 16 selected from the group consisting of 2-[[3-Chloro-4-(2-methylbenzoyl)]phenylamιno]benzonιtrιle (Compound 101 ), 2-Chloro-2'-methyl-4-(2-methyl-phenylamιno)benzophenone (Compound 102), 2-Chloro-2'-methyl-4-(phenylamιno)benzophenone (Compound 103), 2-Chloro-4-(2-methoxy-phenylamιno)-2'-methylbenzophenone (Compound 104), 2-Chloro-4-(2-fluoro-phenyiamιno)-2'-methylbenzophenone (Compound 105), 2-Chloro-4-(2-chloro-phenylamιno)-2'-methylbenzophenone (Compound 106), 4-(2-terf-Butoxy-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 107), 2-Chloro-4-(2-hydroxy-phenylamιno)-2'-methylbenzophenone (Compound 108), 2-Chloro-4-(3-chloro-phenylamιno)-2'-methylbenzophenone (Compound 109), 2-Chloro-4-(2-[1 ,1 ,1-trιfluoromethyl]-phenylamιno)-2'-methylbenzophenone (Compound 110), 4-(4-Bromo-2,5-dιfluoro-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 111 ), 2-Chloro-4-(2-ethyl-phenylamιno)-2'-methylbenzophenone (Compound 112), 2-Chloro-4-(3-[1 ,1 ,1 -trιfluoromethyl]phenylamιno)-2'-methylbenzophenone (Compound 113), 2-Chloro-2'-methyl-4-(2-phenyl-phenylamιno)benzophenone (Compound 1 14), 2-Chloro-2'-methyl-4-(3-phenyl-phenylamιno)benzophenone (Compound 115), 2-Chloro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 1 16), 2-Chloro-2'-methyl-4-(3-methyl-phenylamιno)benzophenone (Compound 117), 2-Chloro-4-(3-methoxy-phenylamιno)-2'-methylbenzophenone (Compound 118), 2-Chloro-4-(4-chloro-phenylamιno)-2'-methylbenzophenone (Compound 119), 2-Chloro-2'-methyl-4-(4-phenyl-phenylamιno)benzophenone (Compound 120), 4-(4-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 121 ), 4-(4-Bromo-3-f luoro-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 122), 4-(2-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 123), 2-Chloro-4-(4-chloro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 124), 2-Chloro-4-(4-chloro-3-fluoro-phenylamιno)-2'-methylbenzophenone (Compound 125), 2-Chloro-4-(3-fluoro-phenylamιno)-2'-methylbenzophenone (Compound 126), 2-Chloro-4-(3,5-dιfluoro-phenylamιno)-2'-methylbenzophenone (Compound 127), 4-(3-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone (Compound 128), 2-Chloro-4-(3,4-dιfluoro-phenylamιno)-2'-methylbenzophenone (Compound 129), 2-Chloro-4-(5-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 130), 2-Chloro-4-(3-f luoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 131 ), Ethyl 2-[[3-chloro-4-(2-methylbenzoyl)]phenylamιno]benzoate (Compound 132), 2-Chloro-3'-fluoro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 133), 2-[[3-Chloro-4-(2-methylbenzoyl)]phenylamιno]benzoιc acid (Compound 134), 2-Chloro-4-(4-fluoro-2-methyl-N-methyl-phenylamιno)-2'-methylbenzophenone (Compound 135), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2'-methylbenzophenone (Compound 136), 4-(4-Bromo-2-chloro-phenylamιno)- 2-chloro-2'-methylbenzophenone (Compound 137), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-methoxy-2'-methylbenzophenone (Compound 138), 4-(4-Bromo-2-methyl-phenylamιno)- 2,4'-dιchloro-2'-methylbenzophenone (Compound 139), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-fluoro-2'-methylbenzophenone (Compound 140), -(4-Bromo-2-methyl-phenylamιno)- 2-fluoro-2'-methylbenzophenone (Compound 141 ), -(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2',5'-dιmethyl-benzophenone (Compound 142), -Chloro-4-(4-cyano-2-methyl-phenylamιno)-2'-methylbenzophenone (Compound 143), 4-(4-Bromo-2-methyl-Λ/-ethyl-phenylamino)-2-chloro-2'-methylbenzophenone (Compound 144), 2-Chloro-4-(4-bromo-2-methyl-phenylamino)-4'-ethoxy-2'-methylbenzophenone (Compound 145), 2, 3'-Dichloro-4-(4-bromo-2-methyl-phenyiamino)-2'-methylbenzophenone (Compound 146), and salts thereof with pharmaceutically acceptable acids, hydrates and solvates. 20.A compound of the general formula la or lb la lb wherein R-| , R2, R3, R4, and R5 have the meanings specified for formula I, and salts thereof with pharmaceutically acceptable acids, hydrates and solvates. 21. A compound of formula la selected from the group consisting of 2-[[3-Chloro-4-(2-methyl(thiobenzoyl))]phenylamino]benzonitrile (Compound 301 ), 2-Chloro-2'-methyl-4-(2-methyl-phenylamino)(thiobenzophenone) (Compound 302), 2-Chloro-2'-methyl-4-(phenylamino)(thiobenzophenone) (Compound 303), 2-Chloro-4-(2-methoxy-phenylamino)-2'-methyl(thiobenzophenone) (Compound 304), 2-Chloro-4-(2-fluoro-phenylamino)-2'-methyl(thiobenzophenone) (Compound 305), 2-Chloro-4-(2-chloro-phenyiamino)-2'-methyl(thiobenzophenone) (Compound 306), 4-(2-ferf-Butyoxy-phenylamino)-2-chloro-2'-methyl(thiobenzophenone) (Compound 307), 2-Chloro-4-(2-hydroxy-phenylamino)-2'-methyl(thiobenzophenone) (Compound 308), 2-Chloro-4-(3-chloro-phenylamino)-2'-methyl(thiobenzophenone) (Compound 309), 2-Chloro-4-(2-[1 ,1 ,1 -trifluoromethyl]-phenylamino)-2'-methyl(thiobenzophenone) (Compound 310), 4-(4-Bromo-2,5-difluoro-phenylamino)-2-chloro-2'-methyl(thiobenzophenone) (Compound 311 ), 2-Chloro-4-(2-ethyl-phenylamino)-2'-methyl(thiobenzophenone) (Compound 312), 2-Chloro-4-(3-[ 1 ,1 ,1 -trif luoromethyl]phenylamino)-2'-methyl(thiobenzophenone) (Compound 313), 2-Chloro-2'-methyl-4-(2-phenyl-phenylamino)(thiobenzophenone) (Compound 314), 2-Chloro-2'-methyl-4-(3-phenyl-phenylamino)(thiobenzophenone) (Compound 315), -Chloro-4-(4-f luoro-2-methyl-phenyiamino)-2'-methyl(thiobenzophenone) (Compound 316), -Chloro-2'-methyl-4-(3-methyl-phenylamino)(thiobenzophenone) (Compound 317), -Chloro-4-(3-methoxy-phenylamino)-2'-methyl(thiobenzophenone) (Compound 318), 2-Chloro-4-(4-chloro-phenylamino)-2'-methyl(thiobenzophenone) (Compound 319), -Chloro-2'-methyl-4-(4-phenyl-phenylamino)(thiobenzophenone) (Compound 320), 4-(4-Bromo-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 321 ), 4-(4-Bromo-3-fluoro-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 322), 4-(2-Bromo-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 323), 2-Chloro-4-(4-chloro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 324), 2-Chloro-4-(4-chloro-3-fluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 325), 2-Chloro-4-(3-fluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 326), 2-Chloro-4-(3,5-dιfluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 327), 4-(3-Bromo-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 328), 2-Chloro-4-(3,4-dιfluoro-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 329), 2-Chloro-4-(5-fluoro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 330), 2-Chloro-4-(3-fluoro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 331 ), Ethyl 2-[[3-chloro-4-(2-methyl(thιobenzoyl))]phenylamιno]benzoate (Compound 332), 2-Chloro-3'-fluoro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 333), 2-[[3-Chloro-4-(2-methyl(thιobenzoyl))Jphenylamιno]benzoιc acid (Compound 334), 2-Chloro-4-(4-fluoro-2-methyl-/V-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 335), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2'-methyl(thιobenzophenone) (Compound 336), 4-(4-Bromo-2-chloro-phenylamιno)- 2-chloro-2'-methyl(thιobenzophenone) (Compound 337), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-methoxy-2'-methyl(thιobenzophenone) (Compound 338), 4-(4-Bromo-2-methyl-phenylamιno)- 2,4'-dιchloro-2'-methyl(thιobenzophenone) (Compound 339), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-fluoro-2'-methyl(thιobenzophenone) (Compound 340), 4-(4-Bromo-2-methyl-phenylamιno)- 2-fluoro-2'-methyl(thιobenzophenone) (Compound 341 ), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2',5'-dιmethyl-(thιobenzophenone) (Compound 342), 2-Chloro-4-(4-cyano-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 343), 4-(4-Bromo-2-methyl-Λ/-ethyl-phenylamιno)-2-chloro-2'-methyl(thιobenzophenone) (Compound 344), 2-Chloro-4-(4-bromo-2-methyl-phenylamιno)-4'-ethoxy-2'-methyl(thιobenzophenone) (Compound 345), 2, 3'-Dιchloro-4-(4-bromo-2-methyl-phenylamιno)-2'-methyl(thιobenzophenone) (Compound 346), and salts thereof with pharmaceutically acceptable acids, hydrates and solvates. 22. A compound of formula lb selected from the group consisting of 2-[[3-Chloro-4-[(hydroxyιmιno)(2-methylphenyl)methyl]]phenylamιno]benzonιtrιle (Compound 401 ), 2-Chloro-2'-methyl-4-(2-methyl-phenylamιno)benzophenone oxime (Compound 402), 2-Chloro-2'-methyl-4-(phenylamιno)benzophenone oxime (Compound 403), 2-Chloro-4-(2-methoxy-phenylamιno)-2'-methylbenzophenone oxime (Compound 404), 2-Chloro-4-(2-fluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 405), 2-Chloro-4-(2-chloro-phenylamιno)-2'-methylbenzophenone oxime (Compound 406), 4-(2-ferf-Butyoxy-phenylamιno)-2-chioro-2'-methylbenzophenone oxime (Compound 407), 2-Chloro-4-(2-hydroxy-phenylamιno)-2'-methylbenzophenone oxime (Compound 408), 2-Chloro-4-(3-chloro-phenylamιno)-2'-methylbenzophenone oxime (Compound 409), 2-Chloro-4-(2-[1 , 1 ,1 -trif luoromethyl]-phenylamιno)-2'-methylbenzophenone oxime (Compound 410), 4-(4-Bromo-2,5-dιfluoro-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 411 ), 2-Chloro-4-(2-ethyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 412), 2-Chloro-4-(3-[1 ,1 ,1 -trιfluoromethyl]phenylamιno)-2'-methylbenzophenone oxime (Compound 413), 2-Chloro-2'-methyl-4-(2-phenyl-phenylamιno)benzophenone oxime (Compound 414), 2-Chloro-2'-methyl-4-(3-phenyl-phenylamιno)benzophenone oxime (Compound 415), 2-Chloro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 416), 2-Chloro-2'-methyl-4-(3-methyl-phenylamιno)benzophenone oxime (Compound 417), 2-Chloro-4-(3-methoxy-phenylamιno)-2'-methylbenzophenone oxime (Compound 418), 2-Chloro-4-(4-chloro-phenylamιno)-2'-methylbenzophenone oxime (Compound 419), 2-Chloro-2'-methyl-4-(4-phenyl-phenylamιno)benzophenone oxime (Compound 420), 4-(4-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone oxιme(Compound 421 ), 4-(4-Bromo-3-fluoro-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 422), 4-(2-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 423), 2-Chloro-4-(4-chloro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 424), 2-Chloro-4-(4-chloro-3-fluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 425), 2-Chloro-4-(3-fluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 426), 2-Chloro-4-(3,5-dιfluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 427), 4-(3-Bromo-phenylamιno)-2-chloro-2'-methylbenzophenone oxime (Compound 428), 2-Chloro-4-(3,4-dιfluoro-phenylamιno)-2'-methylbenzophenone oxime (Compound 429), 2-Chloro-4-(5-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 430), 2-Chloro-4-(3-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 431 ), Ethyl 2-[[3-chloro-4-[(hydroxyιmιno)(2-methylphenyl)methyl]]phenylamιno]benzoate (Compound 432), 2-Chloro-3'-fluoro-4-(4-fluoro-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 433), 2-[[3-Chloro-4-[(hydroxyιmιno](2-methylphenyl)methyl]]phenylamιno]benzoιc acid (Compound 434), 2-Chloro-4-(4-fluoro-2-methyl-Λ/-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 435), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2'-methylbenzophenone oxime (Compound 436), 4-(4-Bromo-2-chloro-phenylamιno)- 2-chloro-2'-methylbenzophenone oxime (Compound 437), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-methoxy-2'-methylbenzophenone oxime (Compound 438), 4-(4-Bromo-2-methyl-phenylamιno)- 2,4'-dιchloro-2'-methylbenzophenone oxime (Compound 439), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-4'-fluoro-2'-methylbenzophenone oxime (Compound 440), 4-(4-Bromo-2-methyl-phenylamιno)- 2-fluoro-2'-methylbenzophenone oxime (Compound 441 ), 4-(4-Bromo-2-methyl-phenylamιno)- 2-chloro-2',5'-dιmethyl-benzophenone oxime (Compound 442), 2-Chloro-4-(4-cyano-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 443), 4-(4-Bromo-2-methyl-Λ/-ethyl-phenylamιno)-2-chioro-2'-methylbenzophenone oxime (Compound 444), 2-Chloro-4-(4-bromo-2-methyl-phenylamιno)-4'-ethoxy-2'-methylbenzophenone oxime (Compound 445), 2, 3'-Dιchloro-4-(4-bromo-2-methyl-phenylamιno)-2'-methylbenzophenone oxime (Compound 446), and salts thereof with pharmaceutically acceptable acids, hydrates and solvates. 23. A compound of formulae I, VII, la, and lb according to any one of the preceding claims in the form of its salt which is formed with a pharmaceutically acceptable inorganic or organic acid selected from the group consisting of hydrochloric, hydrobromic and hydroiodic acid, phosphoric acid, sulphuric acid, nitric acid, p-toluenesulphonic acid, methanesulphonic acid, formic acid, acetic acid, propionic acid, citric acid, tartaric acid, succ ic acid, benzoic acid, and maleic acid. 24. A pharmaceutical composition containing as an active ingredient a compound according to any one of claims 1 to 23 together with a pharmaceutically acceptable carrier and optionally together with a second active ingredient optionally selected from the group consisting of glucocorticoids, vitamin D analogues, anti-histamines, platelet activating factor (PAF) antagonists, anticolinergic agents, methyl xanthines, β-adrenergic agents, COX-2 inhibitors, salicylates, mdomethacin, flufenamate, naproxen, timegadine, gold salts, penicillamme, serum cholesterol-reducing agents, retinoids, zinc salts, and salicylazosulfapyπdin (Salazopyπn). 25 A pharmaceutical composition according to the preceding claim wherein the active ingredient comprises from 0 1 % to 100% by weight of the composition. 26. A pharmaceutical preparation according to claim 24 or 25 in unit dosage form containing between 0.07 mg and 1 g of the active ingredient 27. Use of a compound according to any one of claims 1 to 23 for the preparation of a medicament. 28. Use of a compound according to any one of claim 1 to 23 for the preparation of a medicament for the treatment and/or prophylaxis of asthma, allergy, arthritis, including rheumatoid arthritis and spondyloarthπtis, gout, atherosclerosis, chronic inflammatory bowel disease (Crohn's disease), proliferative and inflammatory skin disorders, such as psoriasis, atopic dermatitis, uveitis, septic shock, AIDS, osteoporosis and acne. 29. A method for the treatment and/or prophylaxis of asthma, allergy, arthritis, including rheumatoid arthritis and spondylo arthritis, gout, atherosclerosis, chronic inflammatory bowel disease (Crohn's disease), proliferative and inflammatory skin disorders, such as psoriasis, atopic dermatitis, uveitis, septic shock, AIDS, osteoporosis and acne, characterised in administering to a patient suffering from at least one of said diseases an effective amount of one or more compounds according to any one of claims 1 to 23 as an active ingredient alone, or if necessary together with a pharmaceutically acceptable carrier, and, optionally, a second active ingredient optionally selected from the group consisting of glucocorticoids, vitamin D analogues, anti-histamines, platelet activating factor (PAF) antagonists, anticolinergic agents, methyl xanthines, β-adrenergic agents, salicylates, mdomethacin, flufenamate, naproxen, timegadπe, gold salts, penicillamme, serum cholesterol-reducing agents, retinoids, zinc salts, and salιcyla.:osulfapyrιdιn (Salazopynn). 30. A method for the treatment and/or prophylaxis of diseases selected from the group consisting of asthma and allergy, characterised in administering to a patient suffering from at least one of said diseases an effective amount of one or more compounds according to any one of claims 1 to 23 as an active ingredient alone, or if necessary together with a pharmaceutically acceptable carrier, and, optionally, a second active ingredient. 31. A method for the treatment and/or prophylaxis of inflammatory diseases selected from the group consisting of arthritis, including rheumatoid arthritis and spondylo arthritis, gout, atherosclerosis, chronic inflammatory bowel disease (Crohn's disease), uveitis and septic shock, characterised in administering to a patient suffering from at least one of said diseases an effective amount of one or more compounds according to any one of claims 1 to 23 as an active ingredient alone, or if necessary together with a pharmaceutically acceptable carrier, and, optionally, a second active ingredient. 32. A method for the treatment and/or prophylaxis of proliferative and inflammatory skin disorders, such as psoriasis, atopic dermatitis and acne, characterised in administering to a patient suffering from at least one of said diseases an effective amount of one or more compounds according to any one of claims 1 to 23 as an active ingredient alone, or if necessary together with a pharmaceutically acceptable carrier, and, optionally, a second active ingredient. 33. A method for the treatment and/or prophylaxis of osteoporosis, characterised in administering to a patient suffering from said disease an effective amount of one or more compounds according to any one of claims 1 to 23 as an active ingredient alone, or if necessary together with a pharmaceutically acceptable carrier, and, optionally, a second active ingredient. 34. A method for the treatment of AIDS related diseases, characterised in administering to a patient suffering from at least one of said diseases an effective amount of one or more compounds according to any one of claims 1 to 23 as an active ingredient alone, or if necessary together with a pharmaceutically acceptable carrier, and, optionally, a second active ingredient. 35. A method of treatment according to any one of claims 29 to 34 comprising administering to a mammal in need of systemic treatment a suitable dose of from 0.1 to 200 mg/kg bodyweight, preferably a dose of from 0.2 to 50 mg/kg of mammal bodyweight one or more times daily of a compound selected from the group consisting of compounds having the formula I, VII, la, and lb.

Inventors: OTTOSEN ERIK RYTTER, OTTOSEN, ERIK, RYTTER
Applicants: LEO PHARM PROD LTD, OTTOSEN ERIK RYTTER, LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOEVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB), OTTOSEN, ERIK, RYTTER
Application year: 2000
Main classification: C07C225
IPC codes: A61K31, A61K45, A61P1, A61P9, A61P11, A61P17, A61P19, A61P29, A61P31, A61P37, C07C225, C07C229, C07C251, C07C255, C07C325