NEUROPATHY IMPROVERS CONTAINING NITROGENOUS COMPOUNDS AS THE ACTIVE INGREDIENT

Abstract: A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below R 4 represents, hydrogen atoms and acyl groups, W represents single bonds and alkylenes, m represents 0 or 1, R 5 and R 6 represent hydrogen atoms, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, aromatic hydrocarbon groups and heterocyclic groups, and R 7 represents hydrogen atoms, acyl groups and alkoxycarbonyl groups. A 2 represents, single bonds, -O-, -NR 3 -, and -S(=O) n -, A 1 and A 3 represent single bonds, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, heterocyclic groups and phenylene groups, and A 4 represents single bonds, carbonyl groups and aliphatic hydrocarbon groups. R 1 and R 2 represent hydrogen atoms, alkyl groups, cycloalkyl groups, phenyl groups and heterocyclic groups. The previously mentioned functional groups may be substituted.]

Description: Technical field The present invention relates to an agent for the remedy of neural damage wherein the active ingredient is a nitrogen-containing compound having a prostacyclin analog structure and an amido group or an amino group at the extremity of the α-chain, as well as pharmaceutical compositions thereof. In addition, the invention relates to a nitrogen-containing compound having a prostacyclin analog structure and an amino group at the extremity of the α-chain, as well as salts thereof. Technical background In the nervous system, neurons perform their function once they have formed a network through synapses between neurons by extending neurites (either axon or dendrite). In addition, such intercellular communication allows the cells to maintain their own existence through a mutual exchange of transmitters and nutritional factors. Therefore, even if the neurons themselves do not suffer fatal damage, if the neural network is damaged, neural functions decrease and, further, may lead to the death of the neurons themselves. Such neural network damage is thought to be what takes place first, not only in cases such as in external injuries where axons are disrupted, but also in many disorders causing neural damage, or in the surroundings of the damaged site. Therefore, a drug agent having a capability such as restoring neural network damage is thought to be both a drug agent capable of controlling the cellular death of neurons and an extremely active drug agent for the remedy of many disorders due to neural damage as well as lesion of nerves due to external injuries. The following may be cited as disorders caused by neural damage: 1) Neuro-degenerative disorders such as Alzheimer's disease, Pick's disease, Lewy body disease, Parkinson's disease, Huntington's chorea, spinocerebellar degeneration and amyotrophic lateral sclerosis, 2) demyelinating disorders such as acute disseminated encephalomyelitis and multiple sclerosis, 3) metabolic disorders such as brain lipidosis and Wilson's Disease, 4) infectious disorders such as meningitis and Creutzfeld-Jacob disease, 5) peripheral neural disorders such as polyneuritis and Guillain-Barre Syndrome, 6) cerebrovascular disorder such as cerebral infarction and transient ischemia, 7) nervous disorders (neuropathies) associated with diabetes and renal diseases and 8) brain tumors. Among the previously mentioned disorders which cause neural damage, Alzheimer's disease is the most representative, and constitutes a serious social issue together with the increase in the population of the elderly. In the past, the drug agents used for treating Alzheimer's disease could be roughly divided into those classified as activators of brain circulation and metabolism, and those classified as cholinergic nervous system activators. However, the activities of these drug agents are not sufficient. In other words, activators of brain circulation and metabolism are drugs that are used to treat cerebrovascular damage and their after-effects, do not aid recovery directly from neural damage and therefore have a low efficacy against dementia which is the core disorder in Alzheimer's disease. In addition, activators of the cholinergic nervous system were developed based on the pathological findings that Alzheimer's disease patients had notable damage in the cholinergic nervous system. However, in Alzheimer's disease, cholinergic nervous systems are actually not the only ones that are damaged, therefore, the effects of such drugs are thought to be limited. Given the situation, development of drugs based on novel drug effects for the treatment of Alzheimer's disease are strongly in demand. Among others, drug agents having an activity such as restoring neural network damage, as mentioned above, are anticipated to display extremely high efficacy for the treatment of Alzheimer's disease, if put into practical application. In the past, for the development of drugs for the treatment of Alzheimer's disease, the models used for evaluating the drug's efficacy at the animal level were mainly models where the cholinergic nervous system was specifically damaged by methods such as administration of scoporamine or electric destruction, or models where damage was produced by cerebral ischemia or hypoxic stress due to carbon dioxide. Although many of these evaluation systems are reasonable as evaluation systems for the activators of the cholinergic nervous system or activators of brain circulation and metabolism, they are pathogenetically and pathologically distant from actual Alzheimer's disease, and are therefore not suited to the evaluation of novel drugs for the treatment of Alzheimer disease. One important characteristic of Alzheimer's disease is the formation of senile plaques in the brain. β-amyloid proteins, which are the main constituents of these senile plaques, agglutinate in the brain to form amyloids and while being deposited in the brain tissue, exhibit their neurotoxicity, which is thought to be the main cause for Alzheimer's disease. Based on this, an animal model of Alzheimer's disease was made, wherein a mini-osmotic pump is implanted under the dorsal skin of a rat, for a continuous intracerebroventricular administration of β-amyloid proteins to lower the ability of learning and memory (Neuroscience Letters, vol. 170, pp.63-66, 1994). In this model, deposition of the β-amyloid proteins could be recognized in the periphery of the cerebral ventricle. However, no clear neural cell death could be observed, therefore, there is a high possibility that the disorder of learning and memory observed in this model are due to damage in the neural network. Therefore, this model is an extremely rational system for screening and evaluating novel drugs for the treatment of Alzheimer's disease, and at the same time, is an adequate system for screening and evaluating novel drugs for the treatment of neural lesion due to a whole range of diseases causing neural damage, or due to injuries. On the other hand, prostaglandin (PG) compounds are known to have multiple physiological activities such as strong platelet aggregation inhibition activity, vasodilatation and the associated hypotension activities, gastric acid secretion inhibition activity, smooth muscle contraction activity, cell protection activity, and diuretic activity. Based on such physiological activities, a number of attempts have been made to develop medicine from natural PG present in vivo , or from PG derivatives synthesized to serve as its agonists, and some of these attempts actually reached the market. Prostacyclin, which is a PG, has the structure represented by the formula below (PGI2), (in the formula, the numbers are identification numbers for the carbon atoms in prostacyclin) which is a substance containing a structure called α-chain comprising the carbon chain from 1 to 7, and a structure called ω-chain from carbon 13 to 20. In vivo it is known as a local hormone, mainly made in the vascular endothelium, and attempts were made to use its strong physiological activities, for example, platelet aggregation inhibition, smooth muscle contraction, hypotension, gastric acid secretion inhibition, peripheral vasodilatation and bronchodilatation, to provide it directly as a medicine (P. J. Lewis, J. O. Grady, Clinical Pharmacology of Prostaglandin). However, because a prostacyclin molecule has a highly hydrolizable enol-ether bond, it is easily inactivated under neutral or acidic conditions, which makes it problematic in compounds to be used as medicines. Therefore, synthetic research was carried out on a compound having a prostacyclin analog structure, displaying the same activity as prostacyclin and being chemically stable (Synthesis, 1984, p. 449). In other words, this objective was achieved mainly by modifying the bicyclo[3.3.0]octane ring structure of from carbon 5 to 12 in prostacyclin. For example, the oxygen atoms bridging position 6 to 9 may be substituted with a methene group (-CH=) to synthesize the compound 9(O)-methano-Δ 6(9α) -prostaglandin I 1 (Isocarbacyclin) indicated by the formula below (Isocarbacyclin), which is a compound having a prostacyclin analog structure fully satisfying the chemical stability (Japanese patent publication Sho. 59-210044). This compound displayed biological activities comparable to those of prostacyclin such as strong platelet aggregation inhibitory activity and vasodilatory-hypotensive activities (Japanese patent publication Sho. 59-210044 and Japanese patent publication Sho. 61-197518). In the past, development of PG compounds to be used as medicine was mainly carried out in the field of obstetrics and gynecology, circulation or digestion. In the nerve field, there are no examples of these compounds commercialized as medicine, although there have been reports on the possibility of using PG compounds in nervous systems. The following are known examples describing in particular the effect of compounds having a prostacyclin analog structure and which remedy neural damage: 1) in Japanese patent publication Sho. 61-129146, a compound having an isocarbacyclin analog structure was used for the prevention of or the treatment of the brain for disorders such as cerebral oxygen deficiency, 2) in Japanese patent publication Hei. 2-167227, a compound having an isocarbacyclin analog structure was used for the treatment of diabetic neuropathy, 3) in Japanese patent publication Hei. 8-245498, Japanese patent publication Hei. 10-101610, Japanese patent publication Hei. 11-5764 and patent No. EP-911314, a compound having an isocarbacyclin analog structure was used as a drug for the treatment of central nervous system disease, via the prostacyclin receptor of the central nervous system 4) in patent No. WO89/03387, 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI 2 derivative was used as a drug for the treatment of cerebral ischemia 5) in Japanese patent publication Hei. 2-262519, beraprost was used for the treatment of diabetic neuropathy, 6) in Japanese patent publication Sho. 63-141927, treatment and prevention of cerebral thrombosis and cerebral infarction. In the previously mentioned examples, however, the efficacy is described for compounds with a carboxyl group at position 1 of the prostacyclin or an ester thereof. Only in the compounds having a prostacyclin analog structure described in the above mentioned 6), a compound having a prostacyclin analog structure wherein the carboxyl group at position 1 is substituted by an amide group is described. However, there is no concrete description related to its pharmacological activity. Therefore, the usability of a compound having a prostacyclin analog structure wherein the carboxyl group at position 1 is substituted with an amide group, as a drug for the remedy of neural damage, was not known. On the other hand, most of the compounds of the past known to have a prostaglandin analog activity, are compounds having a prostacyclin analog structure with, at position 1, a carboxyl group which is thought to be important for expressing the activity, or a chemical structure that can be easily substituted with a carboxyl group in vivo . Therefore, there are only few publicly known substances having a prostacyclin analog structure with an amino group at the extremity of the α-chain. For example, the compound below, described in the (East) German patent No. DD266102, (in the formula, the symbol indicates the E or the Z configuration with respect to the attached double-bond and TBDMS represents a t-butyl-dimethylsilyl group). However, it is positioned as a synthetic intermediate, and a description of its activity is not available. In addition, in the U.S. patent publication No. US4226984, the compounds having the structure indicated below and their substituted versions on the ω-chain are described as having a stimulatory effect on smooth muscles. However, no concrete example is given. In addition, in the Japanese patent publication Sho. 54-117450, a synthesis of the compound having the structure below is described. However, no description on its activity is given. In addition, in the Japanese patent publication Sho. 62-67046, the compounds of the scheme below (in the scheme, THP represents tetrahydropyrane-2-yl group and TBDMS represents a t-butyl-dimethylsilyl group.) and their substituted versions on the ω-chain are described. However, no description of their activity is given In addition, in the Japanese patent publication Hei. 9-67285, the 4 compounds below are described. However, no description of their activity is given. In addition, in the detailed description of WO00/24727, only a description of the anti-helicobacter activity is given, of a derivative of the compound having an amino group at the extremity of the α-chain, comprising the compound indicated by the formula below, and being a compound with a prostacyclin analog structure. Therefore, most of the compounds having a prostacyclin analog structure with an amino group at the extremity of the α-chain were novel substances with no known usability. DE-A-19739693 discloses a composition comprising (1) an interferon-β compound, (2) a prostacyclin, carbacyclin or isocarbacyclin derivative or a prostacyclin mimetic, and (3) a phosphodiesterase IV inhibitor or its salts, racemates or enantiomers; for the treatment of multiple sclerosis and other neurodegenerative disorders. Disclosure of the invention The problem to be solved by the present invention is to provide a novel agent for the remedy of neural damage which can act against disorders due to neural damage, or against neural lesions due to external injuries. Here, disorders caused by neural damage, or disorders caused by neural lesions due to external injuries may be cited as disorders in which the agent for the remedy of neural damage of the present invention can be used. Concretely, the following may be cited as disorders caused by neural damage: 1) Neuro-degenerative disorders such as Alzheimer's disease, Pick's disease, Lewy body disease, Parkinson's disease, Huntington's chorea, spinocerebellar degeneration and amyotrophic lateral sclerosis, 2) demyelinating disorders such as acute disseminated encephalomyelitis and multiple sclerosis, 3) metabolic disorders such as brain lipidosis and Wilson's Disease, 4) infectious disorders such as meningitis and Creutzfeld-Jacob disease, 5) peripheral neuropathies such as polyneuritis and Guillain-Barre Syndrome, 6) cerebrovascular disorder such as cerebral infarction and transient ischemia, 7) nervous disorders (neuropathies) associated with diabetes and renal diseases and 8) brain tumors. In addition, when attempting to develop PG compounds to serve as a medicine in the cerebral nerve field, two problems have to be considered. The first problem is that the diversity of activities that PG compound has may cause adverse events. In order to solve this problem, it is necessary to use compounds that are active as specifically on the cerebral nervous system as possible, with low influences on other parts such as circulatory organs. The second problem is that, in contrast to the vascular system in peripheral organs, in the vascular system of the brain, the vascular endothelial cells are associated by tight junctions, which results in a limitation of the delivery of substances from the circulating blood to the parenchymal tissue of the brain, that is, a so-called blood brain barrier exists. Therefore, in order to develop drug agents for the cerebral nervous system, it is necessary to obtain drugs with a high permeability across the blood brain barrier. After performing extensive research on the above-mentioned problems employing neuroid cells to evaluate the promotion activity on the neurite outgrowth, an evaluation system using an animal model for Alzheimer type dementia wherein β-amyloid protein is continuously injected, and a system to evaluate the decrease of blood pressure, the inventors of the present application found that the nitrogen-containing compound in the formula (1) shown below, having a prostacyclin analog structure and an amido group or an amino group at the extremity of the α-chain, had the activity of promoting the neurite outgrowth, as well as the activity of remedying disorders of learning and memory provoked by the β-amyloid protein. In addition, the above-mentioned compounds showed that they have only a low influence on the peripheral circulatory system, that their activity displays a high specificity for the brain, and that the above mentioned compound has a high permeability across blood brain barriers, allowing the present invention to be completed. In other words, the present invention provides the use of an agent wherein the active ingredient is a nitrogen-containing compound described in Formula (1) shown below: In Formula (1), the symbol represents a single bond or a double bond; G represents one functional group chosen from the group consisting of the Formulae (G1) and (G3) shown below: In Formula (G1) and Formula (G3) the symbol represents the site of linkage with A 1 ; R 4 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group or a group selected from methoxymethyl, 1-ethoxyethyl, 1-methoxy-1-methylethyl, 2-ethoxy-1-methylethyl, 2-methoxyethoxymethyl, tetrahydropyrane-2-yl and 6,6-dimethyl-3-oxa-2-oxo-bicyclo[3.1.0]hexane-4-yl; W represents a single bond, -CH 2 -, -(CH 2 ) 2 -, -(CH 2 ) 3 -, -CH=CH-, -CH=CHCH 2 -, -C≡C- or -C≡CCH 2 -; m may be either 0 or 1, with the proviso that when W is a single bond, m is equal to 1; R 5 and R 6 are either identical or different and, either represents one functional group chosen from the following items 1) to 5): 1) a hydrogen atom; 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, an acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents); 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); or, when R 5 and R 6 are bonded to each other, they represent a substituted or an unsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); R 7 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having 2 to 5 carbon atoms, a sulfonyl group having 1 to 8 carbon atoms, a functional group forming the acetal bond together with the oxygen atom bound to R 7 , or, when R 7 and R 5 are bonded to each other, it represents one portion of the bond forming the carbonyl group together with the carbon atom bonded to R 5 and the oxygen atom bonded to R 7 . A 2 represents a single bond, a Formula (A2A) shown below, a Formula (A2B) shown below or a Formula (A2C) shown below: ―O― In the formula, R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms; In the formula, n represents 0, 1, or 2; A 1 represents the items 1) or 2) below: 1) a single bond; 2) a functional group which bridges G and A 2 through an identical atom or through different atoms, and chosen from: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group; A 3 represents the items 1) or 2) below: 1) a single bond; 2) a functional group which bridges A 2 and A 4 through an identical atom or through different atoms, and chosen from: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group; A 4 represents either of the items 1) to 4) below: 1) a single bond; 2) a carbonyl group; 3) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which bridges the nitrogen atom, bonded to R 1 and R 2 , and A 3 through an identical atom or through different atoms; 4) when A 4 and R 1 are bonded to each other, a functional group forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to (when A 4 or R 1 and the nitrogen atom they are bonded to are bonded through a double bond, R 2 represents the bond between A 4 or R 1 and the nitrogen atom); with the proviso that in the combination of A 1 , A 2 , A 3 and A 4 , A 1 , A 2 , A 3 and A 4 may not simultaneously represent bonds; and when A 2 represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A 2 and the nitrogen atom bonded to R 1 and R 2 must be bonded with more than two carbon atoms in between; R 1 and R 2 are either identical or different, and either represent one functional group chosen from the following items 1) to 7): 1) a hydrogen atom; 2) a substituted or an unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and, heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as substituents); 3) a substituted or an unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 4) a substituted or an unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 6) an acyl group having 1 to 10 carbon atoms when A 4 is not a carbonyl group; 7) a sulfonyl group having 1 to 8 carbon atoms when A 4 is not a carbonyl group (with the proviso that when either R 1 or R 2 represents a sulfonyl group having 1 to 8 carbon atoms, the other may neither be an acyl group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8 carbon atoms), or, when R 1 and R 2 are bonded together, they represent a functional group forming a cyclic amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents; in the manufacture of a medicament for the treatment of neural damage. In addition, the present invention provides a nitrogen-containing compound represented by Formula (2) shown below or a salt thereof: In Formula (2), the symbol represents a single bond or a double bond; G represents one functional group chosen from the group consisting of the Formulae (G1) and (G3), shown below: In Formula (G1) and Formula (G3), the symbol represents the site of linkage with A 10 ; R 4 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group or a group selected from methoxymethyl, 1-ethoxyethyl, 1-methoxy-1-methylethyl, 2-ethoxy-1-methylethyl, 2-methoxyethoxymethyl, tetrahydropyrane-2-yl and 6,6-dimethyl-3-oxa-2-oxo-bicyclo[3.1.0]hexane-4-yl; W represents a single bond, -CH 2 -, -(CH 2 ) 2 -, -(CH 2 ) 3 -, -CH=CH-, -CH=CHCH 2 -, -C=C- or -C≡CCH 2 -; m may be either 0 or 1, with the proviso that when W is a single bond, m is equal to 1; R 5 and R 6 are either identical or different and, either represent one functional group chosen from the following items 1) to 5): 1) a hydrogen atom; 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents); 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); or, when R 5 and R 6 are bonded to each other, they represent a substituted or an unsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); R 7 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having 2 to 5 carbon atoms,a sulfonyl group having 1 to 8 carbon atoms, a functional group forming the acetal bond together with the oxygen atom bound to R 7 , or, when R 7 and R 5 are bonded to each other, it represents one portion of the bond forming the carbonyl group together with the carbon atom bonded to R 5 and the oxygen atom bonded to R 7 ; A 20 represents a single bond, a Formula (A2A) shown below, a Formula (A2B) shown below or a Formula (A2C) shown below: ―O― In the formula, R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms; In the formula, n represents 0, 1, or 2; A 10 represents the items 1) or 2) below: 1) a single bond; 2) a functional group which bridges G and A 20 through an identical atom or through different atoms, and chosen from: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group; A 30 represents the items 1) or 2) below: 1) a single bond; 2) a functional group which bridges A 20 and A 40 through an identical atom or through different atoms, and chosen from: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group; A 40 represents any of the items 1) to 3) below: 1) a single bond; 2) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which bridges the nitrogen atom, bonded to R 10 and R 20 , and A 30 through an identical atom or through different atoms; 3) when A 40 and R 10 are bonded to each other, a functional group forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to (when A 40 or R 10 and the nitrogen atom they are bonded to are bonded through a double bond, R 20 represents the bond between A 40 or R 10 and the nitrogen atom); with the proviso that in the combination of G, A 10 , A 20 , A 30 , and A 40 , when G represents the Formula (G1) and either of A 10 or A 30 is a phenylene group, A 20 may not be a single bond; and when A 20 represents a single bond, then G and the nitrogen atom bonded to R 10 and R 20 must be bonded with more than two carbon atoms in between; and when A 20 represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A 20 and the nitrogen atom bonded to R 10 and R 20 must be bonded with more than two carbon atoms in between; R 10 and R 20 are either identical or different, and either represent one functional group chosen from the following items 1) to 7): 1) a hydrogen atom (with the proviso that when R 10 and R 20 both represent a hydrogen atom, only in the case where G is equal to Formula (G1)); 2) a substituted or an unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and, heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as substituents); 3) a substituted or an unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, an acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 4) a substituted or an unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 5) a substituted or an unsubstituted heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 6) an acyl group having 1 to 10 carbon atoms; 7) a sulfonyl group having 1 to 8 carbon atoms (with the proviso that when either R 10 or R 20 represents a sulfonyl group having 1 to 8 carbon atoms, the other may neither be an acyl group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8 carbon atoms); or, when R 10 and R 20 are bonded together, they represent a functional group forming a cyclic amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents. Preferred embodiments In the following, the present invention will be explained in detail. In Formula (1) above, the symbol represents a single bond or a double bond. G1, may be cited as acceptable G for forming a double bond with such a bonding site. In other words, Formula (1) above, in combination with G, forms one of the Formulae (1-G1) or (1-G3), below. [In Formula (1-G1) and Formula (1-G3), the symbol , A 1 , A 2 , A 3 , A 4 , R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , m and W, have the same definitions as above.] G1, and G3, may be cited as such a preferred functional group for G. G1 is especially preferred. Each of the above Formulae (1-G1), and (1-G3) have a preferred spatial configuration and the ones represented by the Formulae (1-G1E), and (1-G3E) below may be cited. [In Formula (1-G1E) and Formula (1-G3E), the symbol , A 1 ,A 2 ,A 3 ,A 4 ,R 1 ,R 2 ,R 4 ,R 5 , R 6 , R 7 , m, and W have the same definitions as above. The symbol indicates that the bond is in the β position with respect to the carbon atom forming the cyclic structure it is bonded to. The Symbol ----- indicates that the bonds are in the α position with respect to the carbon atoms forming the cyclic structure they are bonded to.] In the above Formula (1), R 4 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group or a functional group forming the acetal bond together with the oxygen atom bonded to R 4 as defined below. As examples of such R 4 which are acyl groups having 2 to 10 carbon atoms, an acetyl group, a trifluoroacetyl group, a propionyl group, a butyryl group, an isobutyryl group, a valeryl group, an hexanoyl group, a benzoyl group, a phenylacetyl group, a phenylpropionyl group, and a cinnamoyl group may be cited. However, an acetyl group and a benzoyl group may be cited as preferred examples. In addition, as examples of a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, a trimethylsilyl group, a triethylsilyl group, a dimethylisopropylsilyl group, a dimethylhexylsilyl group, a t-butyldimethylsilyl group, a triisopropylsilyl group, a t-butyldiphenylsilyl group, and a tribenzylsilyl group may be cited. However, a trimethylsilyl group, a triethylsilyl group, and a t-butyldimethylsilyl group may be cited as preferred examples. Functional groups forming the acetal bond together with the oxygen atom bonded to R 4 are selected from a methoxymethyl, group, a 1-ethoxyethyl group, a 1-methoxy-1-methylethyl group, a 2-ethoxy-1-methylethyl group, a 2-methoxyethoxymethyl group, a tetrahydropyrane-2-yl group and a 6,6-dimethyl-3-oxa-2-oxo-bicyclo[3.1.0]hexane-4-yl group may be cited. However, a methoxymethyl group, a 2-methoxyethoxymethyl group, and a tetrahydropyran-2-yl group may be cited as preferred examples. As particularly preferred examples of such R 4 , a hydrogen atom, an acetyl group, a t-butyldimethylsilyl group and a tetrahydropyran-2-yl group may be cited. In the above formula (1), W represents one of: a single bond, -CH 2 -, -(CH 2 ) 2 -, -(CH 2 ) 3 -, -CH=CH-, -CH=CHCH 2 -, -C≡C- or -C≡CCH 2 -. For said W, -CH=CH- or -CH=CHCH 2 - may be cited as preferred examples. R 5 and R 6 are either identical or different and, either represents one functional group chosen from the following items 1) to 5), i.e., 1) a hydrogen atom, 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbone atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents), 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), or, when R 5 and R 6 are bonded to each other, they represent a substituted or an unsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents). R 7 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having 2 to 5 carbon atoms, a sulfonyl group having 1 to 8 carbon atoms, a functional group forming the acetal bond together with the oxygen atom bound to R 7 , or, when R 7 and R 5 are bonded to each other, R 7 represents one portion of the bond forming the carbonyl group together with the carbon atom bonded to R 5 and the oxygen atom bonded to R 7 . In the partial structure represented by the Formula (W1) below, of the above Formula (1), m may be either 0 or 1. However, when W is a single bond, m is equal to 1. When m equals 1, the above Formula (1) represents Formula (W1A) below, [In the formula, the symbol indicates that R 51 is in the β position with respect to the carbon atom it is bonded to. The symbol indicates that the oxygen atom is in the a position with respect to the carbon atom it is bonded to. R 51 and R 61 are either identical or different and, either represents one functional group chosen from the following items 1) to 5), i.e., 1) a hydrogen atom, 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents), 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), or, when R 51 and R 61 are bonded to each other, they represent a substituted or an unsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents). R 71 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having 2 to 5 carbon atoms, a sulfonyl group having 1 to 8 carbon atoms, and a functional group forming the acetal bond together with the oxygen atom bound to R 71 .] Formula (W1B) below, [In the formula, R 51 , R 61 and R 71 have the same definitions as above. The symbol indicates that the oxygen is in the β position with respect to the carbon atom it is bonded to. The symbol indicates that R 51 is in the α position with respect to the carbon atom it is bonded to.] or Formula (W1C) below, [In the formula, R 62 represents a functional group chosen from the following items 1] to 5], i.e., 1) a hydrogen atom, 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents), 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents)]. If m equals to 0 the above Formula (W1) represents the Formula (W1D) below ―R 62 [In the formula, R 62 has the same definition as above.] When the above Formula (W1) represents the above Formula (W1A) or (W1B), these may be combined in any proportion. In the above formulae(W1A), (W1B), (W1C) or (W1D), R 51 , R 61 and R 62 represent one of the items 1) to 5): 1) a hydrogen atom, 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents), 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents). As examples of such R 51 , R 61 or R 62 which are unsubstituted aliphatic hydrocarbon groups having 1 to 10 carbon atoms; alkyl groups such as a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, an s-butyl group, a t-butyl group, a pentyl group, an isopentyl group, a neopentyl group, a 4-methylpentyl group, a hexyl group, a heptyl group, a 2-methylhexyl group, a 1,1-dimethylpentyl group, an octyl group, a 3,7-dimethyloctyl group, a nonyl group, and a decyl group, alkenyl groups such as a vinyl group, a 1-methylvinyl group, a 1-ethylvinyl group, a 1-propenyl group, a 2-propenyl group, a 2-methyl-1-propenyl group, a 1-butenyl group, a 2-butenyl group, a 2-methyl-1-butenyl group, a 1,3-butadienyl group, a 1-pentenyl group, a 2-pentenyl group, a 4-methyl-1-pentenyl group, a 1-hexenyl group, a 2-hexenyl group, a 3-hexenyl group, a 4-hexenyl group, a 5-hexenyl group, a 1,5-hexadienyl group, a 2-heptenyl group, a 2-octenyl group, a 2-nonenyl group, and a 2-decenyl group, and alkynyl groups such as an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-methyl-1-butynyl group, a 3,3-dimethyl-1-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 3-pentynyl group, a 1-hexynyl group, a 2-hexynyl group, a 3-hexynyl group, a 4-hexynyl group, a 1-methyl-3-pentynyl group, a 1-methyl-3-hexynyl group, a 2-heptynyl group, a 2-octynyl group, a 2-nonynyl group and a 2-decynyl group may be cited. As preferred examples, a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, a hexyl group, a heptyl group, a 2-methylhexyl group, a 1,1-dimethylpentyl group, a 1-propenyl group, a 1-butenyl group, a 2-pentenyl group, a 1-octenyl group and a 1-methyl-3-pentynyl group may be cited. As examples of such R 51 , R 61 or R 62 which are unsubstituted alicyclic hydrocarbon groups having 3 to 8 carbon atoms, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a 1-cyclopentenyl group, a cyclohexyl group, a 1-cyclohexenyl group, a 3-cyclohexenyl group, a 4-cyclohexenyl group, a cycloheptyl group, a 1-cycloheptenyl group, and a cyclooctyl group may be cited. As preferred examples, the cyclopentyl group and the cyclohexyl group may be cited. As examples of such R 51 , R 61 or R 62 which are unsubstituted aromatic hydrocarbon groups having 6 to 10 carbon atoms, a phenyl group, a 1-naphthyl group and a 2-naphthyl group may be cited. As a preferred example, a phenyl group may be cited. As examples of such R 51 , R 61 or R 62 which are unsubstituted heterocyclic groups having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle, monocyclic or bicyclic groups such as a furyl group, a thiophenyl group, a pyrrolyl group, an oxazolyl group, an isooxazolyl group, a thiazolyl group, an isothiazolyl group, an imidazolyl group, a pyrazolyl group, a triazolyl group, a tetrazolyl group, a pyranyl group, a pyridyl group, a pyrazinyl group, a pyrimidinyl group, a pyridazinyl group, a benzofuranyl group, an indolyl group, a benzimidazolyl group, a benzothiazolyl group, a benzoxazolyl group, a quinolyl group, an isoquinolyl group, a quinazolyl group, a purinyl group, a pteridinyl group, an azetidinyl group, a pyrrolidinyl group, a morpholino group, a piperidino group and a piperazinyl group may be cited. As a preferred example, a pyridyl group may be cited. As examples of substitution groups when R 51 , R 61 or R 62 is a substituted aliphatic hydrocarbon group having 1 to 10 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, alkoxy groups having 1 to 4 carbon atoms which are a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group, an s-butoxy group and a t-butoxy group, aryloxy groups having 6 to 10 carbon atoms which are a phenoxy group, a 1-naphthoxy group and a 2-naphthoxy group, aralkoxy groups having 7 to 9 carbon atoms such as a benzyloxy group, an α-phenethyloxy group, a β-phenethyloxy group, a phenylpropyloxy group and a cinnamyloxy group, acyloxy groups having 2 to 10 carbon atoms such as an acetoxy group, a trifluoroacetoxy group, a propionyloxy group, an isopropionyloxy group, a butyryloxy group, an isobutyryloxy group, an s-butyryloxy group, a valeryloxy group, an isovaleryloxy group, a hexanoyloxy group, a heptanoyloxy group, an octanoyloxy group, a nonanoyloxy group, a decanoyloxy group, a benzoyloxy group, a phenylacetyloxy group, a cinnamoyloxy group, a cyclopentylcarboxy group, a cyclohexylcarboxy group and a cycloheptylcarboxy group, sulfonyloxy groups having 1 to 8 carbon atoms such as a methanesulfonyloxy group, a trifluoromethanesulfonyloxy group, an ethanesulfonyloxy group, a butanesulfonyloxy group, a t-butanesulfonyloxy group, a nonafluorobutanesulfonyloxy group, a benzenesulfonyloxy group, a p-bromobenzenesulfonyloxy group, a p-toluenesulfonyloxy group, a benzylsulfonyloxy group, an α-phenethylsulfonyloxy group and a β-phenethylsulfonyloxy group, an oxo group, a carboxyl group, alkoxycarbonyl groups having 2 to 10 carbon atoms such as a methoxycarbonyl group, an ethoxycarbonyl group, a propoxycarbonyl group, an isopropoxycarbonyl group, a butoxycarbonyl group, an isobutoxycarbonyl group, an s-butoxycarbonyl group, a t-butoxycarbonyl group, a phenoxycarbonyl group, a 1-naphthoxycarbonyl group, a 2-naphthoxycarbonyl group, a benzyloxycarbonyl group, an α-phenethyloxycarbonyl group, a β-phenethyloxycarbonyl group, carbamoyl groups having 1 to 15 carbon atoms such as a carbamoyl group, an N-methylcarbamoyl group, an N-ethylcarbamoyl group, an N-propylcarbamoyl group, an N-isopropylcarbamoyl group, an N-butylcarbamoyl group, an N-isobutylcarbamoyl group, an N-s-butylcarbamoyl group, an N-t-butylcarbamoyl group, an N-pentylcarbamoyl group, an N-hexylcarbamoyl group, an N-phenylcarbamoyl group, an N-benzylcarbamoyl group, an N-phenethylcarbamoyl group, an N-cyclopropylcarbamoyl group, an N-cyclobutylcarbamoyl group, an N-cyclopentylcarbamoyl group, an N-cyclohexylcarbamoyl group, an N-cycloheptylcarbamoyl group, an N-cyclopropanemethylcarbamoyl group, an N,N-dimethylcarbamoyl group, an N,N-ethylmethylcarbamoyl group, an N,N-diethylcarbamoyl group, an N,N-dipropylcarbamoyl group, an N,N-dibutylcarbamoyl group, an N,N-dicyclohexylcarbamoyl group, an N,N-diphenylcarbamoyl group, and an N,N-dibenzylcarbamoyl group, amino groups having 0 to 14 carbon atoms such as an amino group, a methylamino group, an ethylamino group, a propylamino group, an isopropylamino group, a butylamino group, an isobutylamino group, an s-butylamino group, a t-butylamino group, a pentylamino group, an hexylamino group, an heptylamino group, an octylamino group, a nonylamino group, a decylamino group, a phenylamino group, a benzylamino group, a phenethylamino group, a cyclopropylamino group, a cyclobutylamino group, a cyclopentylamino group, a cyclohexylamino group, a cycloheptylamino group, a cyclooctylamino group, a cyclopropanemethylamino group, a dimethylamino group, an N-methylamino group, a diethylamino group, an N-methylpropylamino group, an N-methylisopropylamino group, an N-methylbutylamino group, an N-methyl-t-butylamino group, an N-ethylisopropylamino group, a dipropylamino group, a diisopropylamino group, an ethylbutylamino group, an N-methylhexylamino group, a dibutylamino group, a dipentylamino group, a dicyclohexylamino group, a diphenylamino group, a dibenzylamino group a piperidino group and a morpholino group, acylamino groups having 1 to 10 carbon atoms such as a formylamino group, an acetylamino group, a trifluoroacetylamino group, a propionylamino group, a butyrylamino group, an isobutyrylamino group, a valerylamino group, an hexanoylamino group, a benzoylamino group, a phenylacetylamino group, a phenylpropionylamino group, and a cinnamoylamino group, sulfonylamino groups having 1 to 8 carbon atoms such as a methanesulfonylamino group, a trifluoromethanesulfonylamino group, an ethanesulfonylamino group, a butanesulfonylamino group, a t-butanesulfonylamino group, a nonafluorobutanesulfonylamino group, a benzenesulfonylamino group, a p-bromobenzenesulfonylamino group, a p-toluenesulfonylamino group, a benzylsulfonylamino group, an α-phenethylsulfonylamino group and a β-phenethylsulfonylamino group, imino groups having 1 to 10 carbon atoms such as a methylimino group, an ethylimino group, a propylimino group, an isopropylimino group, a butylimino group, an isobutylimino group, a pentylimino group, an hexylimino group, an heptylimino group, an octylimino group, a nonylimino group, a decylimino group, a phenylimino group, a benzylimino group, a phenethylimino group, a cyclopropylimino group, a cyclobutylimino group, a cyclopentylimino group, a cyclohexylimino group, and a cycloheptylimino group, a cyano group, a nitro group, sulfide groups having 1 to 6 carbon atoms such as a methylthio group, an ethylthio group, a propylthio group, an isopropylthio group, a butylthio group, an isobutylthio group, an s-butylthio group, a t-butylthio group, a pentylthio group, an hexylthio group, a phenylthio group, a cyclopentylthio group and a cyclohexylthio group, sulfinyl groups having 1 to 6 carbon atoms such as a methylsulfinyl group, an ethylsulfinyl group, a propylsulfinyl group, an isopropylsulfinyl group, a butylsulfinyl group, an isobutylsulfinyl group, an s-butylsulfinyl group, a t-butylsulfinyl group, a pentylsulfinyl group, a hexylsulfinyl group, a phenylsulfinyl group, a cyclopentylsulfinyl group, and a cyclohexylsulfinyl group, sulfonyl groups having 1 to 6 carbon atoms such as a methylsulfonyl group, an ethylsulfonyl group, a propylsulfonyl group, an isopropylsulfonyl group, a butylsulfonyl group, an isobutylsulfonyl group, an s-butylsulfonyl group, a t-butylsulfonyl group, a pentylsulfonyl group, a hexylsulfonyl group, a phenylsulfonyl group, a cyclopentylsulfonyl group and a cyclohexylsulfonyl group, a substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (in addition to the same examples as the examples chosen among the examples indicated as examples of substitution group in the case of the previously-mentioned aliphatic hydrocarbon group having 1 to 10 carbon atoms, aliphatic hydrocarbon groups having 1 to 6 carbon atoms which are a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, an s-butyl group, an t-butyl group, a pentyl group, a hexyl group, a 2-propenyl group, a 1-butenyl group, a 2-butenyl group, a 2-pentenyl group, a 3-pentenyl group, a 2-hexenyl group, a 3-hexenyl group, a 4-hexenyl group, a 2-butynyl group, a 2-pentynyl group, a 3-pentynyl group, a 2-hexynyl group and a 3-hexynyl group, acyl groups having 1 to 10 carbon atoms such as a formyl group, an acetyl group, a trifluoroacetyl group, a propionyl group, a butyryl group, an isobutyryl group, a valeryl group, an hexanoyl group, a benzoyl group, a phenylacetyl group, a phenylpropionyl group and a cinnamoyl group may be cited as examples of substitution groups for such an alicyclic hydrocarbon group having 3 to 8 carbon atoms), a substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms(in addition to the same examples as the examples chosen among the examples indicated as examples of substitution groups in the case of the previously-mentioned aliphatic hydrocarbon group having 1 to 10 carbon atoms, and in the case of the previously-mentioned alicyclic hydrocarbon group having 3 to 8 carbon atoms, alkyl groups having 1 to 4 carbon atoms which are a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, an s-butyl group and a t-butyl group may be cited as substitution examples for such aromatic hydrocarbon groups having 6 to 10 carbon atoms), a substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (the same examples as the examples chosen among the examples indicated as examples of substitution groups in the case of the previously-mentioned aliphatic hydrocarbon group having 1 to 10 carbon atoms, and in the case of the previously-mentioned alicyclic hydrocarbon group having 3 to 8 carbon atoms may be cited as substitution examples of such a heteocyclic group) may be cited. As preferred examples of such substitution groups for aliphatic hydrocarbon groups having 1 to 10 carbon atoms, a fluorine atom, a hydroxyl group, a phenyl group, a tolyl group, a 4-methoxyphenyl group, a 4-dimethylaminophenyl group, a phenoxy group, a 3,5-dichlorophenoxy group, a cyclopentyl group, a cyclohexyl group, a 3-ethylcyclopentyl group and a phenylsulfonyl group may be cited. As examples of substitution groups when R 51 , R 61 or R 62 are substituted alicyclic hydrocarbon groups having 3 to 8 carbon atoms, the same example as the examples chosen among the examples given for the above-mentioned substituted aliphatic hydrocarbon group having 1 to 10 carbon atoms may be cited. As preferred examples of substitution groups for such alicyclic hydrocarbon groups having 3 to 8 carbon atoms, a methyl group, an ethyl group, a propyl group, a hydroxyl group, a methoxy group and an ethoxy group may be cited. As examples of substitution groups when R 51 , R 61 or R 62 are substituted aromatic hydrocarbon groups having 6 to 10 carbon atoms, the same example as the examples chosen among the examples given for the above-mentioned substituted aliphatic hydrocarbon group having 1 to 10 carbon atoms may be cited. As preferred examples of substitution groups for aromatic hydrocarbon groups having 6 to 10 carbon atoms, a methyl group, an ethyl group, a propyl group, a hydroxyl group, a methoxy group, an ethoxy group, a fluorine atom, a chlorine atom, a bromine atom and an iodine atom may be cited. As examples of substitution groups when R 51 , R 61 or R 62 are substituted heterocyclic groups having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle, the same examples as the examples chosen among the examples given for the above-mentioned substituted aliphatic hydrocarbon group having 1 to 10 carbon atoms may be cited. As preferred examples of substitution groups for such heterocyclic groups having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle, a methyl group, an ethyl group, a propyl group, a hydroxyl group, a methoxy group and an ethoxy group may be cited. In addition, in the above Formula (W1A) or Formula (W1B), R 51 and R 61 are bonded to each other, and represent a substituted or an unsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents). As examples of such unsubstituted alicyclic hydrocarbon chains having 4 to 7 carbon atoms, tetramethylene group, pentamethylene group, hexamethylene group and heptamethylene group may be cited. As preferred examples the tetramethylene group and the pentamethylene group may be cited. As examples of substitution groups wherein R 51 and R 61 are bonded to each other and form a substituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms, the same examples as the examples chosen among the examples given for the above-mentioned substituted aliphatic hydrocarbon group having 1 to 10 carbon atoms may be cited. As preferred examples of substitution groups for such groups forming an alicyclic hydrocarbon chain having 4 to 7 carbon atoms, a methyl group, an ethyl group, a propyl group, a hydroxyl group, a methoxy group and an ethoxy may be cited. In the above Formula (W1A) or Formula (W1B), R 71 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having 2 to 5 carbon atoms, a sulfonyl group having 1 to 8 carbon atoms, a functional group forming the acetal bond together with the oxygen atom bound to R 71 . As examples of such acyl groups having 2 to 10 carbon atoms, an acetyl group, a trifluoroacetyl group, a propionyl group, a butyryl group, an isobutyryl group, a valeryl group, an hexanoyl group, a benzoyl group, a phenylacetyl group, a phenylpropionyl group and a cinnamoly group may be cited. As preferred examples an acetyl group and a benzoyl group may be cited. As examples of tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, a trimethylsilyl group, a triethylsilyl group, a dimethylisopropyls group, a dimethylhexylsilyl group, a t-butyldimethylsilyl group, a triisopropylsilyl group, a t-butyldiphenylsilyl group and a tribenzylsilyl group may be cited. As preferred examples, a trimethylsilyl group, a triethylsilyl group and a t-butyidimethylsilyl group may be cited. As examples of alkoxycarbonyl groups having 2 to 5 carbon atoms, a methoxycarbonyl group, an ethoxycarbonyl group, a propoxycarbonyl group, an isopropoxycarbonyl group, a butoxycarbonyl group, a s-butoxycarbonyl group and a t-butoxycarbonyl group may be cited. As preferred examples, a methoxycarbonyl group and an ethoxycarbonyl group may be cited. As examples of sulfonyl groups having 1 to 8 carbon atoms, a methanesulfonyl group, a trifluoromethanesulfonyl group, an ethanesulfonyl group, a butanesulfonyl group, a t-butanesulfonyl group, a nonafluorobutanesulfonyl group, a benzenesulfonyl group, a p-bromobenzenesulfonyl group, a p-toluenesulfonyl group, a benzylsulfonyl group, an α-phenethylsulfonylamino group, and a β-phenethylsulfonylamino group may be cited. As preferred examples a methanesulfonyl group and a trifluoromethanesulfonyl group may be cited. As examples of functional groups forming the acetal bond together with the oxygen atom bound to R 71 a methoxymethyl group, a 1-ethoxyethyl group, a 1-methoxy-1-methylethyl group, a 2-ethoxy-1-methylethyl group, a 2-methoxyethoxymethyl group, a tetrahydropyrane-2-yl group, a 6,6-dimethyl-3-oxa-2-oxo-bicyclo[3.1.0]hexane-4-yl group may be cited. As preferred examples, a methoxymethyl group, a 2-methoxyethoxymethyl group and a tetrahydropyran-2-yl group may be cited. As particularly preferred such functional groups for R 71 , a hydrogen atom, an acetyl group, a trimethylsilyl group, a t-butyldimethylsilyl group and a tetrahydropyran-2-yl may be cited. As such preferred examples of the above Formula (W1), the items 1) to 6) shown below may be cited. 1) a hydrogen atom, 2) a hydroxymethy group, a formyl group, a methanesulfonyloxymehyl group, a methoxycarbonyloxymethyl group, a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, a hexyl group, a heptyl group, an octyl group, a cyclopentyl group, a cyclohexyl group, a cycloheptyl group, a phenyl group, an o-tolyl group, an m-tolyl group, a p-tolyl group, a 4-methoxyphenyl group, an 4-N,N-dimethylaminophenyl group, a 3-chlorophenyl group, a 4-chlorophenyl group, a 4-fluorophenyl group, a 4-bromophenyl group, 3,5-dichlorophenyl group, a benzyl group, an α-phenethyl group, a β-phenethyl group, an o-tolylmethyl group, an m-tolylmethyl group, a p-tolylmethyl group, a 3-ethylphenyl group, a 4-ethylphenyl group, a 3-propylphenyl group, a 2-(o-tolyl)ethyl group, a 2-(m-tolyl)ethyl group, a 2-(p-tolyl)ethyl group, a 3-(o-tolyl)propyl group, a 3-(m-tolyl)propyl group, a 3-(p-tolyl)propyl group, a 1,1-bis(phenylsulfonyl)-2-(o-tolyl)ethyl group, a 1,1-bis(phenylsulfonyl)-2-(m-tolyl)ethyl group, a 1,1 -bis(phenylsulfonyl)-2-(p-tolyl)ethyl group, a 1,1-bis(phenylsulfonyl)-2-(o-tolyl)propyl group, a 1,1-bis(phenylsulfonyl)-2-(m-tolyl)propyl group, a 1,1-bis(phenylsulfonyl)-2-(p-tolyl)propyl group, 3) a 1-hydroxypentyl group, a 1-hydroxyhexyl group, a 1-hydroxyheptyl group, a 1-hydroxyoctyl group, a 1-hydroxy-1-methylpentyl group, a 1-hydroxy-1-ethylpentyl group, a 1-hydroxy-1-vinylpentyl group, a 1-hydroxy-1-methylhexyl group, a 1-hydroxy-1-ethylhexyl group, a 1-hydroxy-3-methylhexyl group, 1-hydroxy-2-butyl-2-propene group, a 1-hydroxy-2-methylhexyl group, a 1-hydroxy-2-fluorohexyl group, a 1-hydroxy-2,2-dimethylhexyl group, a 1 hydroxy-3-ethoxy-2,2-dimethylpropane group, a 1-hydroxy-2,2-difluorohexyl group, a 1-hydroxy-2,2,6-trimethylheptyl group, a 1-hydroxy-2-fluoro-1-methyloctyl group, a 1-hydroxyhexa-3-enyl group, a 1-hydroxy-5-methylhexa-4-enyl group, a 1-hydroxy-2,5-dimethylhexa-4-enyl group, a 1-hydroxy-3,7-dimethylhexa-4-enyl group, a 1-hydroxy-2,2,5-trimethylhexa-4-enyl group, 1-hydroxy-2,2-dimethylpenta-3-ynyl group, a 1-hydroxy-2,2-dimethylpenta-3-ynyl group, a 1-hydroxyhexa-4-ynyl group, a 1-hydroxy-2-methylhexa-4-ynyl group, a 1-hydroxy-2,2-dimethylhexa-4-ynyl group, a 1-hydroxy-2-methylhepta-4-ynyl group, a 1-hydroxy-4-cyclopropyl-2-methylbutyl group, a 1-hydroxy-2-cyclopentylethyl group, a 1-hydroxy-2-cyclohexylethyl group, a 1-hydroxy-2-phenylethyl group, a 1-hydroxy-2-phenylpropy group, a 1-hydroxy-1-(o-tolyl)methyl group, a 1-hydroxy-1-(m-tolyl)methyl group, a 1-hydroxy-1-(p-tolyl)methyl group, a 1-hydroxy-1-(3-ethylphenyl)methyl group, a 1-hydroxy-1-(4-ethylphenyl)methyl group, a 1-hydroxy-1-(3-propylphenyl)methyl group, a 1-hydroxy-2-(o-tolyl)ethyl group, a 1-hydroxy-2-(m-tolyl)ethyl group, a 1-hydroxy-2-(p-tolyl)ethyl group, a 1-hydroxy-3-(o-tolyl)propyl group, a 1-hydroxy-3-(m-tolyl)propyl group, a 1-hydroxy-3-(p-tolyl)propyl group, a 1-hydroxy-4-(o-tolyl)butyl group, a 1-hydroxy-4-(m-tolyl)butyl group, a 1-hydroxy-4-(p-tolyl)butyl group, a 1-hydroxy-2-(3-chlorophenyl)ethyl group, a 1-hydroxy-2-phenoxylethyl group, a 1-hydroxy-2-(4-fluorophenoxy)ethyl group, a 1-hydroxy-2-(3-chloropheoxyl)ethyl group, a 1-hydroxy-1-cyclopentylmethyl group, a 1-hydroxy-1-cyclohexylmethyl group, a 1-hydroxy-1-cyclopentylethyl group, a 1-hydroxy-1-(4-cyclohexenyl)methyl group, a 1-hydroxy-1-(3-ethylcyclopentyl)methyl group, a 1-hydroxy-1-(2-methylcyclopentyl)methyl group, a 1-hydroxy-1-(2-methylcyclohexyl)methyl group, a 1-hydroxy-1-(3-methylcyclohexyl)methyl group, a 1-hydroxy-1-(4-methylcyclohexyl)methyl group, a 1-hydroxy-1-(2,2,4-trimethylcyclohexyl)methyl group, a 1-hydroxy-1-(1-(2-butynyl) cyclobutyl)methyl group, a 1-hydroxy-1-(1-(2-pentynyl)cyclobutyl)methyl group, a 1-hydroxy-1-phenylmethyl group, a 1-hydroxy-1-(4-chlorophenyl)methyl group, a 1-hydroxy-1-(4-bromophenyl)methyl group, a 1-hydroxy-1-(3-chlorophenyl)methyl group, a 1-hydroxy-1-(4-methoxyphenyl)methyl group, a 1-hydroxy-1-(4-N,N-dimetylaminophenyl)methyl group, a 1-hydroxy-1-(1-naphthyl)methyl group, a 1-hydroxy-1-(2-naphthyl)methyl group, 4) a functional group described in 3) above, wherein the hydroxy group has been substituted for an acetyloxy group, a benzoyloxy group, a trimethylsilyloxy group, a t-butyldimethylsilyloxy group, a tetrahydropyrane-2-yloxy group or a methanesulfonyloxy group, 5) a pentanoyl group, a hexanoyl group, a heptanoyl group, an octanoyl group, a 3-methylhexanoyl group, a 2-methylhexanoyl group, a 2,2-dimethylhexanoyl group, a 2,2,6-trimethylheptanoyl group, a 3-hexenoyl group, a 5-methyl-4-hexenoyl group, a 2,5-dimethyl-4-hexenoyl group, a 3,7-dimethyl-6-octenoyl group, a 2,2,5-trimethyl-4-hexenoyl group, a 3-pentynoyl group, a 2,2-dimethyl-3-pentynoyl group, a 4-hexynoyl group, a 2-methyl-4-hexynoyl group, a 2,2-dimethyl-4-hexynoyl group, a 2-methyl-4-heptynoyl group, a 4-cyclopropyl-2-methylbutanoyl group, a cyclopentylacetyl group, a cyclohexylacetyl group, a 2-phenylacetyl group, a 3-phenylpropanoyl group, a 2-methylbenzoyl group, a 3-methylbenzoyl group, a 4-methylbenzoyl group, a 3-ethylbenzoyl group, a 4-ethylbenzoyl group, a 3-propylbenzoyl group, an (o-tolyl)acetyl group, an (m-tolyl)acetyl group, a (p-tolyl)acetyl group, a 3-(o-tolyl)propanoyl group, a 3-(m-tolyl)propanoyl group, a 3-(p-tolyl)propanoyl group, a 4-(o-tolyl)butanoyl group, a 4-(m-tolyl)butanoyl group, a 4-(p-tolyl)butanoyl group, a (3-chlorophenyl)acetyl group, a cyclopentylcarbonyl group, a cyclohexylcarbonyl group, a 3-ethylcyclopentylcarbonyl group, a 2-methylcyclopentylcarbonyl group, a 2-methylcyclohexylcarbonyl group, a 3-methylcyclohexylcarbonyl group, a 4-methylcyclohexylcarbonyl group, a benzoyl group, a 4-chlorobenzoyl group, a 4-bromobenzoyl group, a 3-chlorobenzoyl group, a 4-methoxybenzoyl group, a 4-N,N-dimethylaminobenzoyl group, a 1-naphthylcarbonyl group, a 2-naphthylcarbonyl group, 6) a 1-pentenyl group, a 1-hexenyl group, a 1-heptenyl group, a 1-octenyl group, a 2-methylhexene-1-yl group, a 2-ethylhexene-1-yl group, a 2-methylheptene-1-yl group, a 2-ethylheptene-1-yl group, a 1-methylhexene-1-yl group, a 1-ethylhexene-1-yl group, a 3-methylhexene-1-yl group, a 1,3-hexadiene-1-yl group, a 5-methyl-1,4-hexadiene-1-yl group, a 2,5-dimethyl-1,4-hexadiene-1-yl group, a 3,7-dimethyl-1,6-octadiene-1-yl group, a penta-3-yn-1-en-1-yl group, a hexa-4-yn-1-en-1-yl group, a 2-methylhexa-4-yn-1-en-1-yl group, a 2-methylhepta-4-yn-1-en-1-yl group, a 4-cyclopropyl-2-methyl-1-butene-1-yl group, a 2-cyclopentylvinyl group, a 2-cyclohexylvinyl group, a 2-phenylvinyl, a 3-phenyl-1-propene-1-yl group, a 2-(o-tolyl)vinyl group, a 2-(m-tolyl)vinyl group, a 2-(p-tolyl)vinyl group, a 3-(o-tolyl)-1-propene-1-yl group, a 3-(m-tolyl)-1-propene-1-yl group, a 3-(p-tolyl)-1-propene-1-yl group, a 4-(o-tolyl)-1-butene-1-yl group, a 4-(m-tolyl)-1-butene-1-yl group, a 4-(p-tolyl)-1-butene-1-yl group, a 2-(3-ethylphenyl)vinyl group, a 2-(4-ethylphenyl)vinyl group, a 2-(3-propylphenyl)vinyl group, a 2-(3-chlorophenyl)vinyl group, a 2-(4-chlorophenyl)vinyl group, a 2-(4-methoxyphenyl)vinyl group, a 2-(4-N,N-dimethylaminophenyl)vinyl group. In the above Formula (1) A 2 represents a single bond, a Formula (A2A) shown below, a Formula (A2B) shown below or a Formula (A2C) shown below. ―O― [In the formula, R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms.] [In the formula, n represents 0, 1, or 2.] In the above Formula (A2B), R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms. As examples of R 3 which are alkyl groups having 1 to 4 carbon atoms, a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, an s-butyl group and a t-butyl group may be cited. As examples of R 3 which are acyl groups having 1 to 10 carbon atoms, a formyl group, an acetyl group, a trifluoroacetyl group, a propionyl group, a butyryl group, an isobutyryl group, a valeryl group, an hexanoyl group, a benzoyl group, a phenylacetyl group, a phenylpropionyl group and a cinnamoly group may be cited. As preferred examples of such an R 3 , a hydrogen atom, a methyl group, a formyl group and an acetyl group may be cited. In the above Formula (A2C), n represents 0, 1, or 2. However, 0 may be cited as the preferred value for n. A single bond, -O-, -NH-, -N(CH 3 )- and -S- may be cited as such preferred functional groups for A 2 . In the above Formula (1), A 1 represents the items 1) or 2) below 1) a single bond 2) a functional group which bridges G and A 2 through an identical atom or through different atoms, and chosen from a group consisting of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group. Examples of such A 1 which are aliphatic hydrocarbon groups having 1 to 3 carbon atoms, are functional groups derived by removing hydrogen atoms from the same carbon atom or two different carbon atoms of a methane, an ethene, a propane, an ethene, a propene, an acetylene or a propyne: when G and A 1 are bonded through a single bond, A 1 is a bivalent functional group derived by removing one hydrogen atom for each bond; when G and A 1 are bonded through a double bond, A 1 is a trivalent functional group derived by removing one hydrogen atom for one bond and two hydrogens for the other bond. As preferred examples of such bivalent functional groups, -CH 2 -, -(CH 2 ) 2 -, -CH(CH 3 )-, -(CH 2 ) 3 -, -C(CH 3 ) 2 -, -CH=CH-, -CH=CHCH 2 -, -CH=C(CH 3 )-, -C≡C- and -C≡CCH 2 - may be cited, and as preferred examples of such trivalent functional groups, =CH-, =CHCH 2 -, =C(CH 3 )-, =CH(CH 2 ) 2 -, =CHCH=CH- and =CH-CH(CH 3 )- may be cited. As examples of A 1 which are alicyclic hydrocarbon groups having 3 to 8 carbon atoms, are functional groups derived from a cyclopropane, a cyclobutane, a cyclopentane, a cyclopentene, a cyclohexane, a cyclohexene, a cycloheptane and a cyclooctane by removing hydrogen atoms on the same carbon atom or two different carbon atoms: when G and A 1 are bonded through a single bond, A 1 is a bivalent functional group derived by removing one hydrogen atom for each bond; when G and A 1 are bonded through a double bond, A 1 is a trivalent functional group derived by removing one hydrogen atom for one bond and two hydrogens for the other bond. As preferred examples of such bivalent functional groups, a 1,2-cyclopropylene group, a cyclopropylydene group, a 1,2-cyclopentylene group, a 1,3-cyclopentylene group, a 1,2-cyclohexylene group, a 1,3-cyclohexylene group, a 1,4-cyclohexylene may be cited, and as a preferred example of such a trivalent functional group, a 1-cyclohexyl-4-ylidedene group may be cited. As examples of A 1 which are heterocyclic groups having between 1 and 2 oxygen atoms, nitrogen atoms, or sulfur atoms, bivalent functional groups derived by removing one hydrogen atom from each of two different carbon atoms such as a furan cycle, a thiofuran cycle, a pyrrole cycle, an oxazole cycle, an isooxazole cycle, a thiazole cycle, an isothioazole cycle, an imidazole cycle, a pyrazole cycle, a pyran group, a pyridine cycle, a pyrazine cycle, a pyrimidine cycle, a pyridazine cycle, an azetidine cycle, a pyrrolidine cycle, a piperidine cycle, a piperazine cycle and a morpholine cycle may be cited. As preferred functional group for such an A 1 , the bond representing a single bond, -CH 2 -, -(CH 2 ) 2 -, =CH- and =CHCH 2 - may be cited. In the above Formula (1), A 3 represents the items 1) or 2) below 1) a single bond 2) a functional group which bridges A 2 and A 4 through an identical atom or through different atoms, and chosen from a group consisting of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group. As examples of such A 3 which are aliphatic hydrocarbon groups having 1 to 3 carbon atoms, alicyclic hydrocarbon groups having 3 to 8 carbon atoms, or heterocycles and which have heterocyclic groups having between 1 and 2 oxygen atoms, nitrogen atoms, or sulfur atoms, among the examples given in the above-mentioned A 1 , the examples given as bivalent functional groups may be may be cited. As particularly preferred functional groups for such A 3 , the bond representing a single bond; -CH 2 -, -(CH 2 ) 2 -, -CH=CH- and a phenylene group may be cited. In the above Formula (1), A 4 represents either of the items 1) to 4) below 1) a single bond 2) a carbonyl group 3) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which bridges the nitrogen atom, bonded to R 1 and R 2 , and A 3 through an identical atom or through different atoms. 4) when A 4 and R 1 are bonded to each other, a functional group forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to (when A 4 or R 1 and the nitrogen atom they are bonded to are bonded through a double bond, R 2 represents the bond between A 4 or R 1 and the nitrogen atom.) When A 4 represents an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which bridges the nitrogen atom, bonded to R 1 and R 2 , and A 3 through an identical atom or through different atoms, such as an aliphatic hydrocarbon group having 1 to 3 carbon atoms is a bivalent functional group derived by removing one hydrogen atom for each bond, from the same carbon atom or two different carbon atoms of a methane, a methene, a propane or a propene. As preferred examples of such A 4 which are aliphatic hydrocarbon groups having 1 to 3 carbon atoms, -CH 2 -, -(CH 2 ) 2 -, -CH(CH 3 )-, -(CH 2 ) 3 -, -C(CH 3 ) 2 - and -CH=CHCH 2 - may be cited. When A 4 represents a functional group wherein A 4 and R 1 are bonded to each other forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to, as examples of such functional groups forming 5 to 8 membered rings, monovalent functional groups derived by removing one hydrogen atom from one carbone atom of a pyrrole cycle, an oxazole cycle, an isooxazole cycle, a thiazole cycle, an isothioazole cycle, a pyrazole cycle, a pyridine cycle, a pyrazine cycle, a pyrimidine cycle, a pyridazine cycle, an azetidine cycle, a pyrrolidine cycle, a piperidine cycle, a piperazine cycle and a morpholine cycle may be cited. When A 4 or R 1 and the nitrogen atom they are bonded to are bonded through a double bond, in other words, when forming a cycle, for example, such as an oxazole cycle, an isooxazole cycle, a thiazole cycle, an isothioazole cycle, an imidazole cycle, a pyrazole cycle, a pyridine cycle, a pyrazine cycle, a pyrimidine cycle and a pyridazine cycle with A 4 , R 1 and the nitrogen atom they are bonded to, R 2 represents a bond between A 4 or R 1 , and the nitrogen atom. As preferred examples of such functional groups forming 5 to 8 membered rings, a 2-pyrrolidinyl group, a 2-piperidinyl group, a 3-piperidinyl group, a 4-piperidinyl group, a 2-piperazinyl group, a 2-morpholinyl group, a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group may be cited. As particularly preferred examples of such a functional group for A 4 , the bond representing a single bond, a carbonyl group, -CH 2 - and -(CH 2 ) 2 - may be cited. In addition, when representing a functional group wherein A 4 and R 1 are bonded to each other forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to, as particularli preferred examples, a 2-pyridyl group, a 4-pyridyl group and a 4-piperidinyl group may be cited. In the above Formula (1), the combination of functional groups A 1 , A 2 , A 3 and A 4 , represented by Formula (A) below, [In Formula (A), A 1 , A 2 , A 3 , A 4 , and the symbol have the same definition as above.] A 1 , A 2 , A 3 and A 4 may not simultaneously represent bonds. In addition, when A 2 represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A 2 and the nitrogen atom bonded to R 1 and R 2 must be bonded with more than two carbon atoms in between. As preferred examples of such functional groups, -(CH 2 ) 3 -, -(CH 2 ) 4 -, -(CH 2 ) 5 -, =CH(CH 2 ) 2 -, =CH(CH 2 ) 3 -, =CH(CH 2 ) 4 -, -CH 2 CH=CHCH 2 -, -NH(CH 2 ) 2 -, -NH(CH 2 ) 3 -, -NH(CH 2 ) 4 -, -N(CH 3 )(CH 2 ) 3 -, -CH 2 NH(CH 2 ) 2 -, -O(CH 2 ) 3 -, -CH 2 O(CH 2 ) 2 -, -S(CH 2 ) 3 -, -CH 2 S(CH 2 ) 2 -, -(o-phenylene)-, -(m-phenylene)-, -(p-phenylene)-, -CH 2 -(o-phenylene)-, -CH 2 -(m-phenylene)-, -CH 2 -(p-phenylene)-, -(CH 2 ) 2 -(o-phenylene)-, -(CH 2 ) 2 -(m-phenylene)-, -(CH 2 ) 2 -(p-phenylene)-, -(o-phenylene)-CH 2 -, -(m-phenylene)-CH 2 -, -(p-phenylene)-CH 2 -, -(o-phenylene)-(CH 2 ) 2 -, -(m-phenylene)-(CH 2 ) 2 -, -(p-phenylene)-(CH 2 ) 2 -, -CH 2 -(o-phenylene)-CH 2 -, -CH 2 -(m-phenylene)-CH 2 -, -CH 2 -(p-phenylene)-CH 2 -, -(CH 2 ) 2 CO-, -(CH 2 ) 3 CO-, -(CH 2 ) 4 CO-, =CHCH 2 CO-, =CH(CH 2 ) 2 CO-, =CH(CH 2 ) 3 CO-, -CH 2 CH=CHCO-, -NHCH 2 CO-, -NH(CH 2 ) 2 CO-, -NH(CH 2 ) 3 CO-, -N(CH 3 )(CH 2 ) 2 CO-, -CH 2 NHCH 2 CO-, -O(CH 2 ) 2 CO-, -CH 2 OCH 2 CO-, -S(CH 2 ) 2 CO-, -CH 2 SCH 2 CO-, -(o-phenylene)-CO-, -(m-phenylene)-CO-, -(p-phenylene)-CO-, -CH 2 -(o-phenylene)-CO-, -(o-phenylene)-CH 2 CO-, -(m-phenylene)-CH 2 CO-, -(p-phenylene)-CH 2 CO-, -CH 2 -(m-phenylene)-CO- and -CH 2 -(p-phenylene)-CO- may be cited. In the above Formula (1), R 1 and R 2 may be identical or different and represent one of the items 1) to 7) shown below. 1) a hydrogen atom, 2) a substituted or an unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and, heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as substituents), 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) 6) an acyl group having 1 to 10 carbon atoms when A 4 is not a carbonyl group, 7) a sulfonyl group having 1 to 8 carbon atoms when A 4 is not a carbonyl group (however, when either R 1 or R 2 represents a sulfonyl group having 1 to 8 carbon atoms, the other may neither be an acyl group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8 carbon atoms), or, when R 1 and R 2 are bonded together, they represent a functional group forming a cyclic amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents). As examples of such R 1 and R 2 which are unsubstituted alkyl groups having 1 to 10 carbon atoms, a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, an s-butyl group, an t-butyl group, a pentyl group, an isopentyl group, a neopentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group and a decyl group may be cited. As examples of unsubstituted cycloalkyl groups having 3 to 8 carbon atoms, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cycloheptyl group and a cyclooctyl group may be cited. As examples of unsubstituted heterocycles, monocyclic or bicyclic functional groups such as a furyl group, a thiophenyl group, a pyrrolyl group, an oxazolyl group, an isooxazolyl group, a thiazolyl group, an isothiazolyl group, an imidazolyl group, a pyrazolyl group, a triazolyl group, a tetrazolyl group, a pyranyl group, a pyridyl group, a pyrazinyl group, a pyrimidinyl group, a pyridazinyl group, a benzofuranyl group, an indolyl group, a benzimidazolyl group, a benzothiazolyl group, a benzoxazolyl group, a quinolyl group, an isoquinolyl group, a quinazolyl group, a purinyl group, a pteridinyl group, an azetidinyl group, a pyrrolidinyl group, a morpholino group, a piperidino group and pyperazinyl may be cited. As examples of substitution groups when R 51 , R 61 or R 62 is a substituted aliphatic hydrocarbon group having 1 to 10 carbon atoms, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, alkoxy groups having 1 to 4 carbon atoms which are a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group, an s-butoxy group and a t-butoxy group, aryloxy groups having 6 to 10 carbon atoms which are a phenoxy group, a 1-naphthoxy group and a 2-naphthoxy group, aralkoxy groups having 7 to 9 carbon atoms such as a benzyloxy group, an α-phenethyloxy group, a β-phenethyloxy group, a phenylpropyloxy group and a cinnamyloxy group, acyloxy groups having 2 to 10 carbon atoms such as an acetoxy group, a trifluoroacetoxy group, a propionyloxy group, an isopropionyloxy group, a butyryloxy group, an isobutyryloxy group, an s-butyryloxy group, a valeryloxy group, an isovaleryloxy group, a hexanoyloxy group, a heptanoyloxy group, an octanoyloxy group, a nonanoyloxy group, a decanoyloxy group, a benzoyloxy group, a phenylacetyloxy group, a cinnamoyloxy group, a cyclopentylcarboxy group, a cyclohexylcarboxy group and a cycloheptylcarboxy group, sulfonyloxy groups having 1 to 8 carbon atoms such as a methanesulfonyloxy group, a trifluoromethanesulfonyloxy group, an ethanesulfonyloxy group, a butanesulfonyloxy group, a t-butanesulfonyloxy group, a nonafluorobutanesulfonyloxy group, a benzenesulfonyloxy group, a p-bromobenzenesulfonyloxy group, a p-toluenesulfonyloxy group, a benzylsulfonyloxy group, an α-phenethylsulfonyloxy group and a β-phenethylsulfonyloxy group, an oxo group, a carboxyl group, alkoxycaobonyl groups having 2 to 10 carbon atoms such as a methoxycarbonyl group, an ethoxycarbonyl group, a propoxycarbonyl group, an isopropoxycarbonyl group, a butoxycarbonyl group, an isobutoxycarbonyl group, an s-butoxycarbonyl group, a t-butoxycarbonyl group, a phenoxycarbonyl group, a 1-naphthoxycarbonyl group, a 2-naphthoxycarbonyl group, a benzyloxycarbonyl group, an α-phenethyloxycarbonyl group and a β-phenethyloxycarbonyl group, carbamoyl groups having 1 to 15 carbon atoms such as a carbamoyl group, an N-methylcarbamoyl group, an N-ethylcarbamoyl group, an N-propylcarbamoyl group, an N-isopropylcarbamoyl group, an N-butylcarbamoyl group, an N-isobutylcarbamoyl group, an N-s-butylcarbamoyl group, an N-t-butylcarbamoyl group, an N-pentylcarbamoyl group, an N-hexylcarbamoyl group, an N-phenylcarbamoyl group, an N-benzylcarbamoyl group, an N-phenethylcarbamoyl group, an N-cyclopropylcarbamoyl group, an N-cyclobutylcarbamoyl group, an N-cyclopentylcarbamoyl group, an N-cyclohexylcarbamoyl group, an N-cycloheptylcarbamoyl group, an N-cyclopropanemethylcarbamoyl group, an N,N-dimethylcarbamoyl group, an N,N-ethylmethylcarbamoyl group, an N,N-diethylcarbamoyl group, an N,N-dipropylcarbamoyl group, an N,N-dibutylcarbamoyl group, an N,N-dicyclohexylcarbamoyl group, an N,N-diphenylcarbamoyl group, an N,N-dibenzylcarbamoyl group, a piperidinocarbonyl group, and a morpholinocarbonyl group, amino groups having 0 to 14 carbon atoms such as an amino group, a methylamino group, an ethylamino group, a propylamino group, an isopropylamino group, a butylamino group, an isobutylamino group, an s-butylamino group, a t-butylamino group, a pentylamino group, an hexylamino group, an heptylamino group, an octylamino group, a nonylamino group, a decylamino group, a phenylamino group, a benzylamino group, a phenethylamino group, a cyclopropylamino group, a cyclobutylamino group, a cyclopentylamino group, a cyclohexylamino group, a cycloheptylamino group, a cyclooctylamino group, a cyclopropanemethylamino group, a dimethylamino group, an N-ethylmethylamino group, a diethylamino group, an N-methylpropylamino group, an N-methylisopropylamino group, an N-methylbutylamino group, an N-methyl-t-butylamino group, an N-ethylisopropylamino group, a dipropylamino group, a diisopropylamino group, an ethylbutylamino group, an N-methylhexylamino group, a dibutylamino group, a dipentylamino group, a dicyclohexylamino group, a diphenylamino group, a dibenzylamino group, a piperidino group and a morpholino group, acylamino groups having 1 to 10 carbon atoms such as a formylamino group, an acetylamino group, a trifluoroacetylamino group, a propionylamino group, a butyrylamino group, an isobutyrylamino group, a valerylamino group, an hexanoylamino group, a benzoylamino group, a phenylacetylamino group, a phenylpropionylamino group, and a cinnamoylamino group, sulfonylamino groups having 1 to 8 carbon atoms such as a methanesulfonylamino group, a trifluoromethanesulfonylamino group, an ethanesulfonylamino group, a butanesulfonylamino group, a t-butanesulfonylamino group, a nonafluorobutanesulfonylamino group, a benzenesulfonylamino group, a p-bromobenzenesulfonylamino group, a p-toluenesulfonylamino group, a benzylsulfonylamino group, an α-phenethylsulfonylamino group and a β-phenethylsulfonylamino group, imino groups having 1 to 10 carbon atoms such as a methylimino group, an ethylimino group, a propylimino group, an isopropylimino group, a butylimino group, an isobutylimino group, a pentylimino group, an hexylimino group, an heptylimino group, an octylimino group, a nonylimino group, a decylimino group, a phenylimino group, a benzylimino group, a phenethylimino group, a cyclopropylimino group, a cyclobutylimino group, a cyclopentylimino group, a cyclohexylimino group, and a cycloheptylimino group, a cyano group, a nitro group, sulfide groups having 1 to 6 carbon atoms such as a methylthio group, an ethylthio group, a propylthio group, an isopropylthio group, a butylthio group, an isobutylthio group, an s-butylthio group, a t-butylthio group, a pentylthio group, an hexylthio group, a phenylthio group, a cyclopentylthio group and a cyclohexylthio group, sulfinyl groups having 1 to 6 carbon atoms such as a methylsulfinyl group, an ethylsulfinyl group, a propylsulfinyl group, an isopropylsulfinyl group, a butylsulfinyl group, an isobutylsulfinyl group, an s-butylsulfinyl group, a t-butylsulfinyl group, a pentylsulfinyl group, a hexylsulfinyl group, a phenylsulfinyl group, a cyclopentylsulfinyl group, and a cyclohexylsulfinyl group, sulfonyl groups having 1 to 6 carbon atoms such as a methylsulfonyl group, an ethylsulfonyl group, a propylsulfonyl group, an isopropylsulfonyl group, a butylsulfonyl group, an isobutylsulfonyl group, an s-butylsulfonyl group, a t-butylsulfonyl group, a pentylsulfonyl group, a hexylsulfonyl group, a phenylsulfonyl group, a cyclopentylsulfonyl group and a cyclohexylsulfonyl group, a substituted or unsubstituted cycloalkyl group having 3 to 8 carbon atoms (in addition to the same examples as the examples chosen among the examples indicated as examples of substitution groups in the case of the previously mentioned alkyl group having 1 to 10 carbon atoms, alkyl groups having 1 to 4 carbon atoms which are a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, an s-butyl and a t-butyl group, acyl groups having 1 to 10 carbon atoms such as a formyl group, an acetyl group, a trifluoroacetyl group, a propionyl group, a butyryl group, an isobutyryl group, a valeryl group, an hexanoyl group, a benzoyl group, a phenylacetyl group, a phenylpropionyl group and a cinnamoyl group may be cited as examples of such cycloalkyl groups having 3 to 8 carbon atoms), a substituted or unsubstituted phenyl group(as examples of substitution groups for such a pheyl group, the substitution groups given in the case of the previously-mentioned alkyl group having 1 to 10 carbon atoms and the same examples as the examples chosen among the examples indicated as examples of substitution groups in the case of the previously-mentioned cycloalkyl groups having 3 to 8 carbon atoms may be cited), a substituted or unsubstituted heterocyclic group(include 1 to 4 oxygen atoms, nitrogen atoms or sulfur atoms. As examples of substitution groups for such a heterocyclic group, the same examples as the examples chosen among the examples indicated as examples of substitution groups in the case of the previously-mentioned alkyl group having 1 to 10 carbon atoms and in the case of the previously-mentioned cycloalkyl groups having 3 to 8 carbon atoms may be cited) may be cited. When R 1 or R 2 represents an acyl group having 1 to 10 carbon atoms, as examples of such an acyl group having 1 to 10 carbon atoms, a formyl group, an acetyl group, a trifluoroacetyl group, a propionyl group, a butyryl group, an isobutyryl group, a valeryl group, an hexanoyl group, a benzoyl group, a phenylacetyl group, a phenylpropionyl group and a cinnamoyl group may be cited. When R 1 or 2 represents a solfonyl group having 1 to 8 carbon atoms, as examples of such a solfonyl group having 1 to 8 carbon atoms, a methanesulfonyl group, a trifluoromethanesulfonyl group, an ethanesulfonyl group, a butanesulfonyl group, a t-butanesulfonyl group, a nonafluorobutanesulfonyl group, a benzenesulfonyl group, a p-bromobenzenesulfonyl group, a p-toluenesulfonyl group, a benzylsulfonyl group, an α-phenethylsulfonyl group, β-phenethylsulfonyl group may be cited. As preferred examples of such R 1 and R 2 , a hydrogen atom, a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, a t-butyl group, a 2-hydroxyethyl group, a carboxymethyl group, a carboxyethyl group, a methoxycarbonylethyl group, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cyclopropylmethyl group, a phenyl group, a tolyl group, a benzyl group, a phenethyl group, a pyridyl group, a 4-pyridyl group, a formyl group, an acetyl group, a propanoyl group, a benzoyl group, a methanesulfonyl group, a benzenesulfonyl group and a p-toluenesulphonyl may be cited. When representing a functional group wherein R 1 and R 2 are bonded to each other and form an amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to, as examples of functional groups forming such an amino group having 4 to 8 carbon atoms, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a morpholino group, a piperazinyl group and a perhydroazepinyl group may be cited. As preferred examples of such amino groups formed by R 1 , R 2 and the nitrogen atom they are bonded to, an amino group, a methylamino group, an ethylamino group, a propylamino group, a butylamino group, a dimethylamino group, an N-methylamino group, a diethylamino group, a dipropylamino group, a diisopropylamino group, a dibutylamino group, an N-methylamino group, a cyclohexylamino group, a phenylamino group, a benzylamino group, a tolylamino group, a (4-pyridylmethyl)amino group, a 2-pyridylamino group, a 1-pyrrolidinyl group, a piperidino group, a morpholino group, a 4-N-methylpiperadin-1-yl group, a carboxymethylamino group, a 1-carboxyethylamino group, a 2-hydroxyethylamino group, a 3-hydroxyethylamino group and a 2-methoxycarbonylethyl group may be cited. In the above Formula (1), the compound represented by the Formula (2) below is a novel substance. [In Formula (2), the symbol represents a single bond or a double bond. G represents one functional group chosen from the group consisting of the Formulae (G1), and (G3) shown below. (In Formula (G1) and Formula (G3) the symbol represents the site of linkage with A 10 . R 4 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group or a functional group forming the acetal bond together with the oxygen atom bonded to R 4 as defined above. W represents a single bond, -CH 2 -, -(CH 2 ) 2 -, -(CH 2 ) 3 -, -CH=CH-, -CH=CHCH 2 -, -C≡C- or -C≡CCH 2 -. m may be either 0 or 1. However, when W is a single bond, m is equal to 1. R 5 and R 6 are either identical or different and, either represent one functional group chosen from the following items 1) to 5), i.e., 1) a hydrogen atom, 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents), 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), or, when R 5 and R 6 are bonded to each other, they represent a substituted or an unsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents). R 7 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having 2 to 5 carbon atoms,a sulfonyl group having 1 to 8 carbon atoms, a functional group forming the acetal bond together with the oxygen atom bound to R 7 , or, when R 7 and R 5 are bonded to each other, it represents one portion of the bond forming the carbonyl group together with the carbon atom bonded to R 5 and the oxygen atom bonded to R 7 . A 20 represents a single bond, a Formula (A2A) shown below, a Formula (A2B) shown below or a Formula (A2C) shown below. ―O― (In the formula, R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms.) (In the formula, n represents 0, 1, or 2.) A 10 represents the items 1) or 2) below 1) a single bond 2) a functional group which bridges G and A 20 through an identical atom or through different atoms, and chosen from a group consisting of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group. A 30 represents the items 1) or 2) below 1) a single bond 2) a functional group which bridges A 20 and A 40 through an identical atom or through different atoms, and chosen from a group consisting of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group. A 40 represents any of the items 1) to 3) below 1) a single bond 2) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which bridges the nitrogen atom, bonded to R 10 and R 20 , and A 30 through an identical atom or through different atoms. 3) when A 40 and R 10 are bonded to each other, a functional group forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to (when A 40 or R 10 and the nitrogen atom they are bonded to are bonded through a double bond, R 20 represents the bond between A 40 or R 10 and the nitrogen atom.) However, in the combination of G, A 10 , A 20 , A 30 , and A 40 of the above Formula (2), when G represents the Formula (G1), and either of A 10 or A 30 is a phenylene group, A 20 may not be a single bond. And when A 20 represents a single bond, then G and the nitrogen atom bonded to R 10 and R 20 must be bonded with more than two carbon atoms in between. In addition, when A 20 represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A 20 and the nitrogen atom bonded to R 10 and R 20 must be bonded with more than two carbon atoms in between. R 10 and R 20 are either identical or different, and either represent one functional group chosen from the following items 1) to 7), i.e., 1) a hydrogen atom (however, when R 10 and R 20 both represent a hydrogen atom, only in the case where G is equal to Formula (G1)), 2) a substituted or an unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and, heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as substituents), 3) a substituted or an unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 4) a substituted or an unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 6) an acyl group having 1 to 10 carbon atoms 7) a sulfonyl group having 1 to 8 carbon atoms (however, when either R 10 or R 20 represents a sulfonyl group having 1 to 8 carbon atoms, the other may be neither an acyl group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8 carbon atoms), or, when R 10 and R 20 are bonded together, they represent a functional group forming a cyclic amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents)] The same examples given for G in the above Formula (1) may be cited as preferred examples for G in the above Formula (2). In the above Formula (2), A 20 represents a single bond, a Formula (A2A) shown below, a Formula (A2B) shown below or a Formula (A2C) shown below. ―O― [In the formula, R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms.] [In the formula, n represents 0, 1, or 2.] The same examples given as concrete examples for R 3 in the above Formula (1) may be cited as concrete examples for R 3 in the above Formula (A2B). In the above Formula (A2C), n represents 0, 1, or 2. However, 0 may be cited as the preferred value for n. A single bond, -O-, -NH-, -N(CH 3 )- and -S- may be cited as such preferred functional groups for A 20 . A 10 represents the items 1) or 2) below 1) a single bond 2) a functional group which bridges G and A 20 through an identical atom or through different atoms, and chosen from a group consisting of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group. The same examples given as concrete examples for A 1 in the above Formula (1) may be cited as such concrete examples for A 10 . A bond representing a single bond, -CH 2 -, -(CH 2 ) 2 -, =CH- and =CHCH 2 - may be cited as particularly preferred functional groups. In the above Formula (2), A 30 represents the items 1) or 2) below 1) a single bond 2) a functional group which bridges A 20 and A 40 through an identical atom or through different atoms, and chosen from a group consisting of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group. The same examples given as concrete examples for A 3 in the above Formula (1) may be cited as concrete examples for A 30 . A bond representing a single bond, -CH 2 -, -(CH 2 ) 2 - and -CH=CH- may be cited as particularly preferred functional groups. In the above Formula (2), A 40 represents any of the items 1) to 3) below 1) a single bond 2) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which bridges the nitrogen atom, bonded to R 10 and R 20 , and A 30 through an identical atom or through different atoms. 3) when A 40 and R 10 are bonded to each other, a functional group forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to (when A 40 or R 10 and the nitrogen atom they are bonded to are bonded through a double bond, R 20 represents the bond between A 40 or R 10 and the nitrogen atom.). The same examples given as concrete examples for A 4 in the above Formula (1) may be cited as such concrete examples for A 40 . A bond representing a single bond, -CH 2 - and -(CH 2 ) 2 - may be cited as particularly preferred functional groups. In addition, when A 40 and R 10 are bonded to each other, to represent a functional group forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to, 2-pyridyl, 4-pyridyl and 4-piperidinyl may be cited as particularly preferred examples. However, in the combination of G, A 10 , A 20 , A 30 , and A 40 , when G represents the Formula (G1), and either of A 10 or A 30 is a phenylene group, A 20 may not be a single bond. And when A 20 represents a single bond, then G and the nitrogen atom bonded to R 10 and R 20 must be bonded with more than two carbon atoms in between. In addition, when A 20 represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A 20 and the nitrogen atom bonded to R 10 and R 20 must be bonded with more than two carbon atoms in between. In the above Formula (2), as preferred examples of functional groups represented by the Formula (A0) below, [In Formula (A0), A 10 , A 20 , A 30 , A 40 , and the symbol have the same definition as above.] -(CH 2 ) 3 -, -(CH 2 ) 4 -, -(CH 2 ) 5 -, =CH(CH 2 ) 2 -, =CH(CH 2 ) 3 -, =CH(CH 2 ) 4 -, -CH 2 CH=CHCH 2 -, -NH(CH 2 ) 2 -, -NH(CH 2 ) 3 -, -NH(CH 2 ) 4 -, -N(CH 3 )(CH 2 ) 3 -, -CH 2 NH(CH 2 ) 2 -, -O(CH 2 ) 3 -, -CH 2 O(CH 2 ) 2 -, -S(CH 2 ) 3 - and -CH 2 S(CH 2 ) 2 - may be cited. In the above Formula (2), R 10 and R 20 are either identical or different, and either represent one functional group chosen from the following items 1) to 7), i.e., 1) a hydrogen atom (however, when R 10 and R 20 both represent a hydrogen atom, only in the case where G is equal to Formula (G1)), 2) a substituted or an unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and, heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as substituents), 3) a substituted or an unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 4) a substituted or an unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon-atoms may be cited as substituents), 5) a substituted or an unsubstituted heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), 6) an acyl group having 1 to 10 carbon atoms 7) a sulfonyl group having 1 to 8 carbon atoms (however, when either R 10 or R 20 represents a sulfonyl group having 1 to 8 carbon atoms, the other may neither be an acyl group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8 carbon atoms), or, when R 10 and R 20 are bonded together, they represent a functional group forming a cyclic amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents). As concrete examples of R 10 and R 20 , the same examples as the examples given in the above Formula (1) as concrete examples may be cited, and, as particularly preferred examples, a hydrogen atom, a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, a t-butyl group, a 2-hydroxyethyl group, a 3-hydroxyethyl group, a carboxymethyl group, a carboxyethyl group, a methoxycarbonylethyl group, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cyclopropylmethyl group, a phenyl group, a tolyl group, a benzyl group, a phenethyl group, a pyridyl group, a 4-pyridyl group, a formyl group, an acetyl group, a propanoyl group, a benzoyl group, a methanesulfonyl group, a benzenesulfonyl group and a p-toluenesulfonyl may be cited. When representing a functional group wherein R 1 and R 2 are bonded to each other and form an amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to, as examples of functional groups forming such an amino group having 4 to 8 carbon atoms, the same examples as the examples given in the above Formula (1) as concrete examples of R 1 and R 2 may be cited. As preferred examples of such amino groups formed by R 10 , R 20 and the nitrogen atom they are bonded to, an amino group, a methylamino group, an ethylamino group, a propylamino group, a butylamino group, a dimethylamino group, an N-methylamino group, a diethylamino group, a dipropylamino group, a diisopropylamino group, a dibutylamino group, an N-methylamino group, a cyclohexylamino group, a phenylamino group, a benzylamino group, a tolylamino group, a (4-pyridylmethyl)amino group, a 2-pyridylamino group, a 1-pyrrolidinyl group, a piperidino group, a morpholino group, a 4-N-methylpiperadin-1-yl group, a carboxymethylamino group, a 1-carboxyethylamino group, a 2-hydroxyethylamino group, and a 3-hydroxyethylamino group may be cited. There are instances where the nitrogen-containing compound represented by the above Formula (1) may form salts. No particular restriction exists for such salts provided they are pharmacologically accepted. Concretely, mineral acid salts such as hydrochlorides, hydrobromates, hydroiodates, phosphates, nitrates, and sulfates, organic sulfonates such as methane sulfonates, 1-hydroxyethane sulfonates, and p-toluenesulfonates, and, organic carboxylates such as acetates, trifluoroacetates, propionates, oxalates, malonates, succinates, glutarates, adipinates, tartrates, maleates, malates and mendelates may be included as added acidic salts, and, salts formed with inorganic bases such as sodium salts, potassium salts, magnesium salts, calcium salts, inorganic salt groups such as aluminium salts, and, salts formed with organic bases such as methylamine salts, ethylamine salts, lysine salts, and ornithin salts may be cited as salts made with bases. Concrete examples of the nitrogen-containing compounds represented by the above Formula (1) provided by the present invention will be given in the following. However, the invention is not limited to these examples. 1) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo [3.3.0]-2-octene 2) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 3) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 4) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 5) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 6) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 7) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 8) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 9) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 10) (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 11) (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 12) (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 13) (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 14) (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 15) (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 16) (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 17) (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 18) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 19) (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 20) (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 21) (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 22) (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 23) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 24) (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 25) (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 26) (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 27) (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 28) (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 29) (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 30) (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 31) (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 32) (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 33) (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(3S,1E)-3-hydroxy-3-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 34) (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 35) (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 36) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 37) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 38) (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 39) (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 40) (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 41) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 42) (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 43) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 44) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 45) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 46) (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 47) (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 48) (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 49) (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 50) (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 51) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 52) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 53) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 54) (1S,5S,6R,7R)-3-[N-(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 55) (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 56) (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 57) (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 58) (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 59) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 60) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 61) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 62) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 63) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 64) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 65) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 66) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 67) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 68) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 69) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 70) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 71) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 72) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 73) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 74) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 75) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 76) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 77) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 78) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 79) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 80) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 81) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 82) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 83) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 84) (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 85) (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 86) (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 87) (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 88) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 89) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 90) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 91) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 92) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 93) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 94) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 95) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 96) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 97) (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 98) (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 99) (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 100) (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 101) (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 102) (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 103) (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 104) (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 105) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 106) (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 107) (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 108) (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 109) (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 110) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 111) (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 112) (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 113) (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 114) (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 115) (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 116) (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 117) (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicydo[3.3.0]-2-octene 118) (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 119) (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 120) (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 121) (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 122) (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 123) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 124) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 125) (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 126) (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 127) (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 128) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 129) (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 130) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 131) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 132) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 133) (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 134) (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 135) (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 136) (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 137) (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 138) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 139) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 140) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 141) (1S,5S,6R,7R)-3-[N-(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 142) (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 143) (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 144) (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 145) (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 146) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 147) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 148) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 149) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 150) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 151) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 152) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 153) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 154) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 155) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 156) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 157) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 158) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 159) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 160) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 161) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 162) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 163) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 164) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 165) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 166) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 167) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 168) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 169) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 170) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 171) (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 172) (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 173) (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 174) (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 175) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 176) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 177) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 178) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 179) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 180) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 181) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 182) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 183) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 184) (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 185) (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 186) (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 187) (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 188) (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 189) (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 190) (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 191) (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 192) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 193) (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 194) (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 195) (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-zoctene 196) (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicydo[3.3.0]-2-octene 197) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 198) (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 199) (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 200) (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 201) (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 202) (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 203) (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 204) (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(45,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 205) (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 206) (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 207) (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 208) (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 209) (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 210) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 211) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 212) (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 213) (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 214) (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 215) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 216) (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 217) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 218) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 219) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 220) (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 221) (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 222) (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 223) (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 224) (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 225) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 226) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 227) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 228) (1S,5S,6R,7R)-3-[N-(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 229) (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 230) (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 231) (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 232) (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 233) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 234) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 235) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 236) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 237) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 238) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 239) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 240) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 241) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 242) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 243) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 244) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 245) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 246) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 247) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 248) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 249) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 250) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 251) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 252) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 253) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 254) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 255) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 256) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 257) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 258) (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 259) (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 260) (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 261) (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 262) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 263) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 264) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 265) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 266) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 267) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 268) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 269) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 270) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 271) (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 272) (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 273) (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 274) (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 275) (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 276) (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 277) (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 278) (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 279) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 280) (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 281) (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 282) (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 283) (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 284) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 285) (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 286) (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 287) (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 288) (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 289) (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 290) (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 291) (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 292) (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 293) (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 294) (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 295) (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 296) (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 297) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 298) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 299) (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 300) (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 301) (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 302) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 303) (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 304) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 305) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 306) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 307) (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 308) (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 309) (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 310) (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 311) (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 312) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 313) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 314) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 315) (1S,5S,6R,7R)-3-[N-(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 316) (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 317) (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 318) (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 319) (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 320) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 321) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 322) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 323) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 324) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 325) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 326) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 327) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 328) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 329) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 330) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 331) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 332) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 333) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 334) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 335) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 336) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 337) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 338) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 339) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 340) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 341) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 342) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 343) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 344) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 345) (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 346) (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 347) (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 348) (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 349) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 350) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 351) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 352) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 353) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 354) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 355) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 356) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 357) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 358) (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 359) (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 360) (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 361) (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 362) (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 363) (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 364) (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 365) (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 366) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 367) (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 368) (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 369) (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 370) (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 371) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 372) (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 373) (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 374) (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 375) (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 376) (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 377) (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 378) (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 379) (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 380) (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 381) (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 382) (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 383) (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 384) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 385) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 386) (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 387) (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 388) (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 389) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 390) (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 391) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 392) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 393) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 394) (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 395) (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 396) (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 397) (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 398) (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 399) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 400) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 401) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 402) (1S,5S,6R,7R)-3-[N-(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 403) (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 404) (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 405) (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 406) (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 407) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 408) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 409) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 410) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 411) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 412) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 413) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 414) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 415) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 416) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 417) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 418) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 419) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 420) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 421) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 422) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 423) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 424) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 425) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 426) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 427) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 428) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 429) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 430) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 431) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 432) (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 433) (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 434) (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 435) (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 436) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 437) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 438) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 439) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 440) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 441) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 442) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 443) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 444) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 445) (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 446) (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 447) (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 448) (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 449) (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 450) (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 451) (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 452) (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 453) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 454) (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 455) (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 456) (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 457) (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 458) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 459) (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 460) (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 461) (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 462) (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 463) (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 464) (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 465) (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 466) (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 467) (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 468) (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 469) (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 470) (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 471) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 472) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 473) (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 474) (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 475) (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 476) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 477) (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 478) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 479) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 480) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 481) (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 482) (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 483) (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 484) (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 485) (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 486) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 487) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 488) (1S,5S,6R,7R)-3-[N-(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 489) (1S,5S,6R,7R)-3-[N-(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 490) (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 491) (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 492) (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 493) (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 494) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 495) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxypethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 496) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 497) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 498) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 499) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 500) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 501) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 502) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 503) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 504) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 505) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 506) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 507) (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 508) (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 509) (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 510) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 511) (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 512) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 513) (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 514) (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 515) (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 516) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 517) (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 518) (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 519) (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 520) (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 521) (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 522) (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 523) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 524) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 525) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 526) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 527) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 528) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 529) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 530) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 531) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 532) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group 533) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 534) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 535) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 536) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 537) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 538) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarhamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 539) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 540) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 541) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 542) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (4R,1E)-4-hydroxy-4-methyl-1-octenyl group 543) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 544) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 545) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 546) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 547) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 548) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 549) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 550) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 551) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 552) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group 553) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 554) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 555) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 556) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 557) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 558) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 559) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 560) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 561) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 562) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group 563) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxyl-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 564) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 565) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 566) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 567) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 568) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 569) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 570) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 571) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 572) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group 573) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 574) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 575) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 576) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 577) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 578) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 579) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 580) (1S,5S,6R,7R)-3-(4-pigeridinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 581) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 582) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group 583) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 584) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 585) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 586) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 587) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 588) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 589) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 590) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 591) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 592) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group 593) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 594) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 595) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 596) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 597) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 598) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 599) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 600) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 601) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 602) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group 603) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 604) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 605) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 606) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 607) (1S,5S,6R,7R)-3-(4-N-(4-pyridylmethyl)carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 608) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 609) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 610) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 611) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 612) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group 613) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 614) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 615) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 616) (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 617) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 618) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 619) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 620) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 621) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 622) compounds of compound numbers 10 to 87 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3R,1E)-3-hydroxy-1-octenyl group 623) (1S,5S,6R,7S)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 624) (1S,5S,6R,7S)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 625) (1R,5R,6S,7S)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 626) (1R,5R,6S,7S)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 627) (1R,5R,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 628) (1R,5R,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 629) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-hydroxy-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 630) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 631) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 632) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 633) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 634) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene 635) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene 636) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene 637) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene 638) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 639) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 640) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene 641) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene 642) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 643) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 644) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 655) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 646) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 647) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-(3-ethylcyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 648) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-(3-ethylcyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 649) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 650) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 651) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 652) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 653) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 654) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 655) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 656) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 657) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 658) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 659) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 660) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 661) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 662) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 663) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 664) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 665) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 666) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 667) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 668) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 669) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 670) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 671) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 672) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 673) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 674) (1S,5S,6R,7R)-3-(4,N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 675) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 676) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(4-N,N-dimethylaminophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 677) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(4-N,N-dimethylaminophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 678) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(3-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 679) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(3-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 680) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(4-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 681) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(4-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 682) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 683) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 684) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 685) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 686) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 687) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 688) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 689) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 690) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 691) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 692) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 693) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 694) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 695) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 696) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 697) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 698) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E,5Z)-3-hydroxy-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 699) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E,5Z)-3-hydroxy-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 700) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 701) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 702) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 703) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 704) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4,4-dimethyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 705) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4,4-dimethyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 706) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 707) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 708) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 709) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 710) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 711) (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-1-octynyl]-7-hydroxybicyclo[3.3.0]-2-octene 712) (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-1-octynyl]-7-hydroxybicyclo[3.3.0]-2-octene 713) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1Z)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 714) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1Z)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 715) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxyoctyl]-7-hydroxybicyclo[3.3.0]-2-octene 716) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxyoctyl]-7-hydroxybicyclo[3.3.0]-2-octene 717) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-3-methyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene 718) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-3-methyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene 719) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-4,4-dimethyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene 720) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-4,4-dimethyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene 721) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-3-phenylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene 722) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-3-phenylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene 723) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-4-phenylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene 724) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-4-phenylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene 725) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-4-(m-tolyl)butyl]-7-hydroxybicyclo[3.3.0]-2-octene 726) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-4-(m-tolyl)butyl]-7-hydroxybicyclo[3.3.0]-2-octene 727) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-3-cyclopentylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene 728) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-3-cyclopentylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene 729) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 730) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 731) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-hydroxy-4-butyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 732) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-butyl-1,5-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 733) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-butyl-1,5-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 734) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-cyclopentyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 735) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-cyclopentyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 736) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-cyclohexyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 737) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-cyclohexyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 738) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 739) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 740) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-(1-hydroxycyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 741) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-(1-hydroxycyclohexyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 742) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 743) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 744) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 745) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 746) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,5S)-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 747) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,5R)-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 748) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E,5S)-5-methyl-1,3-nonadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 749) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E,5R)-5-methyl-1,3-nonadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 750) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,4R)-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 751) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,4S)-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 752) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-4-methyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 753) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,4R)-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 754) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,4S)-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 755) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-4-ethyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 756) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-butyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 757) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,5Z)-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 758) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E,5Z)-1,3,5-octatrienyl]-7-hydroxybicyclo[3.3.0]-2-octene 759) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-cyclopentyliden-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 760) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-cyclohexyliden-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 761) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-2-phenylvinyl]-7-hydroxybicyclo[3.3.0]-2-octene 762) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-2-(o-tolyl)vinyl]-7-hydroxybicyclo[3.3.0]-2-octene 763) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-2-(m-tolyl)vinyl]-7-hydroxybicyclo[3.3.0]-2-octene 764) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-2-(p-tolyl)vinyl]-7-hydroxybicyclo[3.3.0]-2-octene 765) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 766) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 767) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-4-phenyl-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 768) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-4-phenyl-3-methyl-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 769) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 770) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 771) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 772) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-4-(m-tolyl)-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 773) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 774) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-5-(m-tolyl)-1,3-pentadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 775) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4,4-bisphenylsulfonyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 776) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-5-(m-tolyl)-1,3-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 777) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(4-phenoxybutyl)-7-hydroxybicyclo[3.3.0]-2-octene 778) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 779) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 780) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 781) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene 782) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene 783) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 784) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 785) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene 786) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-3-oxo-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 787) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-3-oxo-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 788) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 789) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(5S,1E)-3-oxo-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 790) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(5R,1E)3-oxo-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 791) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 792) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 793) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 794) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 795) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 796) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 797) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 798) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 799) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 800) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 801) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 802) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 803) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 804) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 805) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 806) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 807) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-hydroxymethyl-7-hydroxybicyclo[3.3.0]-2-octene 808) (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxyethyl]-7-hydroxybicyclo[3.3.0]-2-octene 809) (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxyethyl]-7-hydroxybicyclo[3.3.0]-2-octene 810) (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene 811) (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene 812) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxy-1-methylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene 813) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxy-1-methylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene 814) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R,2E)-1-hydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 815) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S,2E)-1-hydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 816) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R,3S,2E)-1,3-dihydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 817) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S,3S,2E)-1,3-dihydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 818) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R,3S,2E)-1,3-dihydroxy-4-cyclopentyl-2-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 819) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S,3S,2E)-1,3-dihydroxy-4-cyclopentyl-2-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 820) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R,3S,2E)-1,3-dihydroxy-5-phenyl-2-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 821) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S,3S,2E)-1,3-dihydroxy-5-phenyl-2-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 822) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxy-2-pentynyl]-7-hydroxybicyclo[3.3.0]-2-octene 823) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxy-2-pentynyl]-7-hydroxybicyclo[3.3.0]-2-octene 824) (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxy-5-phenoxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene 825) (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxy-5-phenoxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene 826) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxyphenylmethyl]-7-hydroxybicyclo[3.3.0]-2-octene 827) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxyphenylmethyl]-7-hydroxybicyclo[3.3.0]-2-octene 828) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(o-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 829) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(o-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 830) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(m-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 831) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(m-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 832) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(p-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 833) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(p-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 834) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(4-methoxyphenyl) methyl]-7-hydroxybicyclo[3.3.0]-2-octene 835) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(4-methoxyphenyl) methyl]-7-hydroxybicyclo[3.3.0]-2-octene 836) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(4-N,N-dimethylaminophenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 837) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(4-N,N-dimethylaminophenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 838) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(3-chlorophenyl) methyl]-7-hydroxybicyclo[3.3.0]-2-octene 839) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(3-chlorophenyl) methyl]-7-hydroxybicyclo[3.3.0]-2-octene 840) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-formyl-7-hydroxybicyclo[3.3.0]-2-octene 841) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-acetyl-7-hydroxybicyclo[3.3.0]-2-octene 842) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-benzoyl-7-hydroxybicyclo[3.3.0]-2-octene 843) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(o-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene 844) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(m-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene 845) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(p-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene 846) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(4-methoxyphenylcarbonyl)-7-hydroxybicyclo[3.3.0]-2-octene 847) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(4-N,N-dimethylaminophenyl carbonyl)-7-hydroxybicyclo[3.3.0]-2-octene 848) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(3-chlorophenylcarbonyl)-7-hydroxybicyclo[3.3.0]-2-octene 849) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-phenylvinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 850) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(4-methoxyphenyl)vinyl carbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 851) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(4-N,N-dimethylamino phenyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 852) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(3-chlorophenyl)vinyl carbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 853) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(2-thienyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 854) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(4-pyridyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 855) compounds of compound numbers 623 to 854 of the examples given above, wherein the 4-N,N-dimethylcarbamoylbutyl group, which is a substitution group at position 3 of the bicyclo[3.3.0]-2-octene cycle, has been replaced by either of the 4-carbamoylbutyl group, the 4-N,N-diethylcarbamoylbutyl group, the 4-N-(2-methoxycarbonylethyl)carbamoylbutyl group, the 4-N-(4-pyridylmethyl)carbamoylbutyl group, the 4-N,N-diisopropylcarbamoylbutyl group, the 4-(1-pyrrolidinyl)carbonylbutyl group, the 4-piperidinocarbonylbutyl group or the 4-morpholinocarbonylbutyl group 856) (1S,2R,3R,5S)-7-[(E)-4-carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 857) (1S,2R,3R,5S)-7-[(E)-4-N-methylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 858) (1S,2R,3R,5S)-7-[(E)-4-N-ethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 859) (1S,2R,3R,5S)-7-[(E)-4-N-propylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 860) (1S,2R,3R,5S)-7-[(E)-4-N-isopropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 861) (1S,2R,3R,5S)-7-[(E)-4-N-butylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 862) (1S,2R,3R,5S)-7-[(E)-4-N-t-butylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 863) (1S,2R,3R,5S)-7-[(E)-4-N-phenylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 864) (1S,2R,3R,5S)-7-[(E)-4-N-benzylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 865) (1S,2R,3R,5S)-7-[(E)-4-N-(4-pyridylmethyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 866) (1S,2R,3R,5S)-7-[(E)-4-(1-pyrrolidinyl)carbonylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 867) (1S,2R,3R,5S)-7-[(E)-4-piperidinocarbonylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 868) (1S,2R,3R,5S)-7-[(E)-4-morpholinocarbonylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 869) (1S,2R,3R,5S)-7-[(E)-4-(4-N-methyl-1-piperazinyl)carbonylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 870) (1S,2R,3R,5S)-7-[(E)-4-N-(2-pyridyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 871) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 872) (1S,2R,3R,5S)-7-[(E)-4-N,N-diethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 873) (1S,2R,3R,5S)-7-[(E)-4-N,N-dipropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 874) (1S,2R,3R,5S)-7-[(E)-4-N,N-diisopropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 875) (1S,2R,3R,5S)-7-[(E)-4-N,N-dibutylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 876) (1S,2R,3R,5S)-7-[(E)-4-N-t-butyl-N-methylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 877) (1S,2R,3R,5S)-7-[(E)-4-N-(2-hydroxyethyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 878) (1S,2R,3R,5S)-7-[(E)-4-N-(3-hydroxypropyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 879) (1S,2R,3R,5S)-7-[(E)-3-carbamoylpropylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 880) (1S,2R,3R,5S)-7-[(E)-3-N,N-dimethylcarbamoylpropylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 881) (1S,2R,3R,5S)-7-[(E)-5-carbamoylpentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 882) (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylcarbamoylpentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 883) (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 884) (1S,2R,3R,5S)-7-[(E)-2-(N,N-diisopropylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 885) (1S,2R,3R,5S)-7-[(E)-2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 886) (1S,2R,3R,5S)-7-[(E)-2-[(1-pyrrolidinyl)carbonylmethyl]oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 887) (1S,2R,3R,5S)-7-[(E)-2-(piperidinocarbonylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 888) (1S,2R,3R,5S)-7-[(E)-2-(morpholinocarbonylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 889) (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)thioethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 890) (1S,2R,3R,5S)-7-[(E)-2-N-(N,N-dimethylcarbamoylmethyl)aminoethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 891) (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethoxymethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 892) (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethylthiomethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 893) (1S,2R,3R,5S)-7-[(E)-N-(N,N-dimethylcarbamoylmethyl)aminomethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 894) (1S,2R,3R,5S)-7-[(E)-4-carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 895) (1S,2R,3R,5S)-7-[(E)-4-N-methylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 896) (1S,2R,3R,5S)-7-[(E)-4-N-ethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 897) (1S,2R,3R,5S)-7-[(E)-4-N-propylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 898) (1S,2R,3R,5S)-7-[(E)-4-N-isopropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 899) (1S,2R,3R,5S)-7-[(E)-4-N-butylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 900) (1S,2R,3R,5S)-7-[(E)-4-N-t-butylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 901) (1S,2R,3R,5S)-7-[(E)-4-N-phenylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 902) (1S,2R,3R,5S)-7-[(E)-4-N-benrylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 903) (1S,2R,3R,5S)-7-[(E)-4-N-(4-pyridylmethyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 904) (1S,2R,3R,5S)-7-[(E)-4-(1-pyrrolidinyl)carbonylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 905) (1S,2R,3R,5S)-7-[(E)-4-piperidinocarbonylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 906) (1S,2R,3R,5S)-7-[(E)-4-morpholinocarbonylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 907) (1S,2R,3R,5S)-7-[(E)-4-(4-N-methyl-1-piperazinyl)carbonylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 908) (1S,2R,3R,5S)-7-[(E)-4-N-(2-pyridyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 909) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 910) (1S,2R,3R,5S)-7-[(E)-4-N,N-diethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 911) (1S,2R,3R,5S)-7-[(E)-4-N,N-dipropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 912) (1S,2R,3R,5S)-7-[(E)-4-N,N-diisopropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 913) (1S,2R,3R,5S)-7-[(E)-4-N,N-dibutylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 914) (1S,2R,3R,5S)-7-[(E)-4-N-t-butyl-N-methylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 915) (1S,2R,3R,5S)-7-[(E)-4-N-(2-hydroxyethyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 916) (1S,2R,3R,3S)-7-[(E)-4-N-(3-hydroxypropyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 917) (1S,2R,3R,5S)-7-[(E)-3-carbamoylpropylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 918) (1S,2R,3R,5S)-7-[(E)-3-N,N-dimethylcarbamoylpropylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 919) (1S,2R,3R,5S)-7-[(E)-5-carbamoylpentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 920) (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylcarbamoylpentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 921) (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 922) (1S,2R,3R,5S)-7-[(E)-2-(N,N-diisopropylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 923) (1S,2R,3R,5S)-7-[(E)-2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 924) (1S,2R,3R,5S)-7-[(E)-2-[(1-pyrrolidinyl)carbonylmethyl]oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 925) (1S,2R,3R,5S)-7-[(E)-2-(piperidinocarbonylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 926) (1S,2R,3R,5S)-7-[(E)-2-(morpholinocarbonylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 927) (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)thioethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 928) (1S,2R,3R,5S)-7-[(E)-2-N-(N,N-dimethylcarbamoylmethyl)aminoethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 929) (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethoxymethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 930) (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethylthiomethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 931) (1S,2R,3R,5S)-7-[(E)-N-(N,N-dimethylcarbamoylmethyl)aminomethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 932) (1S,2R,3R,5S)-7-[(E)-4-carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 933) (1S,2R,3R,5S)-7-[(E)-4-N-methylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 934) (1S,2R,3R,5S)-7-[(E)-4-N-ethylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 935) (1S,2R,3R,5S)-7-[(E)-4-N-propylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 936) (1S,2R,3R,5S)-7-[(E)-4-N-isopropylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 937) (1S,2R,3R,5S)-7-[(E)-4-N-butylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 938) (1S,2R,3R,5S)-7-[(E)-4-N-t-butylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 939) (1S,2R,3R,5S)-7-[(E)-4-N-phenylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 940) (1S,2R,3R,5S)-7-[(E)-4-N-benzylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 941) (1S,2R,3R,5S)-7-[(E)-4-N-(4-pyridylmethyl)carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 942) (1S,2R,3R,5S)-7-[(E)-4-(1-pyrrolidinyl)carbonylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 943) (1S,2R,3R,5S)-7-[(E)-4-piperidinocarbonylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 944) (1S,2R,3R,5S)-7-[(E)-4-morpholinocarbonylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 945) (1S,2R,3R,5S)-7-[(E)-4-(4-N-methyl-1-piperazinyl)carbonylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 946) (1S,2R,3R,5S)-7-[(E)-4-N-(2-pyridyl)carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 947) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 948) (1S,2R,3R,5S)-7-[(E)-4-N,N-diethylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 949) (1S,2R,3R,5S)-7-[(E)-4-N,N-dipropylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 950) (1S,2R,3R,5S)-7-[(E)-4-N,N-diisopropylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 951) (1S,2R,3R,5S)-7-[(E)-4-N,N-dibutylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 952) (1S,2R,3R,5S)-7-[(E)-4-N-t-butyl-N-methylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 953) (1S,2R,3R,5S)-7-[(E)-4-N-(2-hydroxyethyl)carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 954) (1S,2R,3R,5S)-7-[(E)-4-N-(3-hydroxypropyl)carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 955) (1S,2R,3R,5S)-7-[(E)-3-carbamoylpropylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 956) (1S,2R,3R,5S)-7-[(E)-3-N,N-dimethylcarbamoylpropylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 957) (1S,2R,3R,5S)-7-[(E)-5-carbamoylpentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 958) (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylcarbamoylpentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 959) (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 960) (1S,2R,3R,5S)-7-[(E)-2-(N,N-diisopropylcarbamoylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 961) (1S,2R,3R,5S)-7-[(E)-2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 962) (1S,2R,3R,5S)-7-[(E)-2-[(1-pyrrolidinyl)carbonylmethyl]oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 963) (1S,2R,3R,5S)-7-[(E)-2-(piperidinocarbonylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 964) (1S,2R,3R,5S)-7-[(E)-2-(morpholinocarbonylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 965) (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)thioethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 966) (1S,2R,3R,5S)-7-[(E)-2-N-(N,N-dimethylcarbamoylmethyl)aminoethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 967) (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethoxymethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 968) (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethylthiomethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 969) (1S,2R,3R,5S)-7-[(E)-N-(N,N-dimethylcarbamoylmethyl)aminomethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 970) (1S,2R,3R,5S)-7-[(E)-4-carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 971) (1S,2R,3R,5S)-7-[(E)-4-N-methylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 972) (1S,2R,3R,5S)-7-[(E)-4-N-ethylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 973) (1S,2R,3R,5S)-7-[(E)-4-N-propylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 974) (1S,2R,3R,5S)-7-[(E)-4-N-isopropylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 975) (1S,2R,3R,5S)-7-[(E)-4-N-butylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 976) (1S,2R,3R,5S)-7-[(E)-4-N-t-butylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 977) (1S,2R,3R,5S)-7-[(E)-4-N-phenylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 978) (1S,2R,3R,5S)-7-[(E)-4-N-benzylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 979) (1S,2R,3R,5S)-7-[(E)-4-N-(4-pyridylmethyl)carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 980) (1S,2R,3R,5S)-7-[(E)-4-(1-pyrrolidinyl)carbonylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 981) (1S,2R,3R,5S)-7-[(E)-4-piperidinocarbonylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 982) (1S,2R,3R,5S)-7-[(E)-4-morpholinocarbonylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 983) (1S,2R,3R,5S)-7-[(E)-4-(4-N-methyl-1-piperazinyl)carbonylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 984) (1S,2R,3R,5S)-7-[(E)-4-N-(2-pyridyl)carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 985) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 986) (1S,2R,3R,5S)-7-[(E)-4-N,N-diethylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 987) (1S,2R,3R,5S)-7-[(E)-4-N,N-dipropylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 988) (1S,2R,3R,5S)-7-[(E)-4-N,N-diisopropylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 989) (1S,2R,3R,5S)-7-[(E)-4-N,N-dibutylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 990) (1S,2R,3R,5S)-7-[(E)-4-N-t-butyl-N-methylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 991) (1S,2R,3R,5S)-7-[(E)-4-N-(2-hydroxyethyl)carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 992) (1S,2R,3R,5S)-7-[(E)-4-N-(3-hydroxypropyl)carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 993) (1S,2R,3R,5S)-7-[(E)-3-carbamoylpropylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 994) (1S,2R,3R,5S)-7-[(E)-3-N,N-dimethylcarbamoylpropylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 995) (1S,2R,3R,5S)-7-[(E)-5-carbamoylpentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 996) (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylcarbamoylpentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 997) (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 998) (1S,2R,3R,5S)-7-[(E)-2-(N,N-diisopropylcarbamoylmethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 999) (1S,2R,3R,5S)-7-[(E)-2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1000) (1S,2R,3R,5S)-7-[(E)-2-[(1-pyrrolidinyl)carbonylmethyl]oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1001) (1S,2R,3R,5S)-7-[(E)-2-(piperidinocarbonylmethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1002) (1S,2R,3R,5S)-7-[(E)-2-(morpholinocarbonylmethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1003) (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)thioethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1004) (1S,2R,3R,5S)-7-[(E)-2-N-(N,N-dimethylcarbamoylmethyl)aminoethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1005) (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethoxymethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1006) (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethylthiomethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1007) (1S,2R,3R,5S)-7-[(E)-N-(N,N-dimethylcarbamoylmethyl)aminomethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 1008) compounds of compound numbers 856 to 893 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group which is a substitution group bonded to the carbon at position 12 of the prostacyclin carbon identification number, has been replaced by either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (E)-4-(m-tolyl)-1-butenyl group, the (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group, or, the (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group or the 2-(1-hydroxycyclohexyl)ethynyl group 1009) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-carbamoylpropyl)-1H-cyclopenta[b]benzofuran 1010) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1011) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-ethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1012) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-propylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1013) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-isopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1014) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1015) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-t-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1016) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-phenylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1017) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-benzylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1018) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-N-(4-pyridylmethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1019) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-(1-pyrrolidinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran 1020) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-piperidinocarbonylpropyl)-1H-cyclopenta[b]benzofuran 1021) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-morpholinocarbonylpropyl)-1H-cyclopenta[b]benzofuran 1022) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-(4-N-methyl-1-piperazinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran 1023) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-N-(2-pyridyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1024) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N,N-dimethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1025) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N,N-diethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1026) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N,N-dipropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1027) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N,N-diisopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1028) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N,N-dibutylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1029) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-t-butyl-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1030) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-N-(2-hydroxyethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1031) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-N-(3-hydroxypropyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1032) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(2-carbamoylethyl)-1H-cyclopenta[b]benzofuran 1033) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(2-N,N-dimethylcarbamoylethyl)-1H-cyclopenta[b]benzofuran 1034) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-carbamoylbutyl)-1H-cyclopenta[b]benzofuran 1035) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N,N-dimethylcarbamoylbutyl)-1H-cyclopenta[b]benzofuran 1036) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(2-N,N-dimethylcarbamoylethyloxy)-1H-cyclopenta[b]benzofuran 1037) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-carbamoylpropyl)-1H-cyclopenta[b]benzofuran 1038) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1039) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-ethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1040) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-propylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1041) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-isopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1042) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1043) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-t-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1044) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-phenylcarbamoylpropyl)-1H-cydopenta[b]benzofuran 1045) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-benzylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1046) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(4-pyridylmethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1047) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-(1-pyrrolidinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran 1048) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-piperidinocarbonylpropyl)-1H-cyclopenta[b]benzofuran 1049) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-morpholinocarbonylpropyl)-1H-cyclopenta[b]benzofuran 1050) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-(4-N-methyl-1-piperazinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran 1051) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(2-pyridyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1052) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1053) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-diethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1054) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dipropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1055) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-diisopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1056) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dibutylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1057) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-t-butyl-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1058) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(2-hydroxyethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1059) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(3-hydroxypropyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1060) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-carbamoylethyl)-1H-cyclopenta[b]benzofuran 1061) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-N,N-dimethylcarbamoylethyl)-1H-cyclopenta[b]benzofuran 1062) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-carbamoylbutyl)-1H-cyclopenta[b]benzofuran 1063) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dimethylcarbamoylbutyl)-1H-cyclopenta[b]benzofuran 1064) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-N,N-dimethylcarbamoylethyloxy)-1H-cyclopenta[b]benzofuran 1065) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-carbamoylpropyl)-1H-cyclopenta[b]benzofuran 1066) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1067) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-ethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1068) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-propylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1069) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-isopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1070) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1071) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-t-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1072) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-phenylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1073) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-benzylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1074) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(4-pyridylmethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1075) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-(1-pyrrolidinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran 1076) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-piperidinocarbonylpropyl)-1H-cyclopenta[b]benzofuran 1077) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-morpholinocarbonylpropyl)-1H-cyclopenta[b]benzofuran 1078) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-(4-N-methyl-1-piperazinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran 1079) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(2-pyridyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1080) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1081) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-diethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1082) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dipropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1083) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-diisopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1084) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dibutylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 1085) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-t-butyl-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran. 1086) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(2-hydroxyethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1087) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(3-hydroxypropyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran 1088) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-carbamoylethyl)-1H-cyclopenta[b]benzofuran 1089) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-N,N-dimethylcarbamoylethyl)-1H-cyclopenta[b]benzofuran 1090) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-carbamoylbutyl)-1H-cyclopenta[b]benzofuran 1091) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dimethylcarbamoylbutyl)-1H-cyclopenta[b]benzofuran 1092) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-N,N-dimethylcarbamoylethyloxy)-1H-cyclopenta[b]benzofuran 1093) compounds of compound numbers 1009 to 1036 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group bonded to the carbon at position 12 of the prostacyclin carbon identification number, has been replaced by either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (E)-4-(m-tolyl)-1-butenyl group, the (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group, the (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group or the (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group 1094) (1S,2R,3R,5S)-7-[(Z)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1095) (1R,5S,7R,8R)-3-(4-N,N-dimethylcarbamoylbutyl)-8-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1096) (1S,2R,3R,5S,7R)-7-(4-N,N-dimethylcarbamoylbutyl)-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1097) (1S,2R,3R,5S,7R)-7-[2-(N,N-dimethylaminocarbamoylmethoxy)ethyl]-2-[(3R,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-3-hydroxybicyclo[3.3.0]octane 1098) (1S,3S,5R,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-oxabicyclo[3.3.0]octane 1099) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-oxabicyclo[3.3.0]-3-octen 1100) (1S,5R,6R,7R)-3-[(Z)-4-N,N-dimethylcarbamoylbutylidene]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-4-oxo-2-oxabicyclo[3.3.0]octane 1101) (1S,3S,5R,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-thiabicyclo[3.3.0]octane 1102) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-azabicyclo[3.3.0]-2-octene 1103) (1S,3S,5R,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-azabicyclo[3.3.0]octane 1104) compounds of compound numbers 1094 to 1103 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group bonded to the carbon at position 12 of the prostacyclin carbon identification number, has been replaced by either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (E)-4-(m-tolyl)-1-butenyl group, the (3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group, the (3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group, the (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group, the (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group or the (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group 1105) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1106) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1107) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1108) (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1109) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1110) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1111) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1112) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1113) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1114) (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1115) (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1116) (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1117) (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1118) (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1119) (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1120) (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1121) (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1122) (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1123) (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1124) (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1125) (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1126) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1127) (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1128) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1129) (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1130) (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1131) (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1132) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1133) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1134) (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1135) (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1136) (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1137) (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1138) (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1139) (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1140) (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1141) (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1142) (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1143) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1144) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1145) (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1146) (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1147) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1148) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1149) (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1150) (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1151) (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1152) (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1153) (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1154) (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1155) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1156) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1157) (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1158) (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1159) (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1160) (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1161) (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1162) (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1163) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1164) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1165) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1166) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1167) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1168) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1169) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1170) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1171) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1172) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1173) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1174) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1175) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1176) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1177) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1178) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1179) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1180) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1181) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1182) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1183) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1184) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1185) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1186) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1187) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1188) (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1189) (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1190) (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1191) (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1192) (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1193) (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1194) (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1195) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1196) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1197) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1198) (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1199) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1200) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1201) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1202) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1203) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1204) (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1205) (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1206) (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1207) (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1208) (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1209) (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1210) (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1211) (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1212) (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1213) (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1214) (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1215) (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1216) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1217) (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1218) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1219) (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1220) (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1221) (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1222) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1223) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1224) (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1225) (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1226) (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1227) (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1228) (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1229) (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1230) (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1231) (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1232) (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1233) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1234) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1235) (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1236) (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1237) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1238) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1239) (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1240) (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1241) (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1242) (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1243) (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1244) (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1245) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1246) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1247) (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1248) (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1249) (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1250) (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1251) (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1252) (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1253) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1254) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1255) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1256) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1257) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1258) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1259) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1260) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1261) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1262) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1263) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1264) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1265) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1266) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1267) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1268) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1269) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1270) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1271) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1272) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1273) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1274) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1275) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1276) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1277) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1278) (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1279) (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1280) (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1281) (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1282) (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1283) (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1284) (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1285) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1286) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1287) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1288) (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1289) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1290) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1291) (1S,5S,6R,7R),3-[5-(1-pyrrolidinyl)pentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1292) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1293) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1294) (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1295) (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1296) (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1297) (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1298) (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1299) (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1300) (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1301) (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1302) (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1303) (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1304) (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1305) (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1306) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1307) (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1308) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1309) (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1310) (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1311) (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1312) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1313) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1314) (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1315) (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1316) (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1317) (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1318) (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1319) (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1320) (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1321) (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1322) (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1323) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1324) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1325) (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1326) (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1327) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1328) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1329) (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1330) (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1331) (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1332) (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1333) (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1334) (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1335) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1336) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1337) (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1338) (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1339) (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1340) (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1341) (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1342) (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1343) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1344) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1345) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1346) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1347) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1348) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1349) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1350) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1351) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1352) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1353) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1354) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1355) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1356) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1357) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1358) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1359) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1360) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1361) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1362) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1363) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1364) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1365) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1366) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1367) (1S,5S,6R,7R)-3-[(3,N,N-dimethylaminophenyl)methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1368) (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1369) (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1370) (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1371) (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1372) (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1373) (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1374) (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1375) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1376) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1377) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1378) (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1379) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1380) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1381) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1382) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1383) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1384) (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1385) (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1386) (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1387) (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1388) (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1389) (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1390) (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1391) (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1392) (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1393) (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1394) (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1395) (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1396) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1397) (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1398) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1399) (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene . 1400) (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1401) (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1402) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1403) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1404) (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1405) (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1406) (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1407) (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1408) (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1409) (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1410) (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1411) (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1412) (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1413) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1414) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1415) (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1416) (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1417) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1418) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1419) (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1420) (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1421) (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1422) (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1423) (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1424) (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1425) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1426) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1427) (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1428) (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1429) (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1430) (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1431) (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1432) (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1433) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1434) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1435) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicydo[3.3.0]-2-octene 1436) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1437) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1438) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1439) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1440) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1441) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1442) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1443) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1444) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1445) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1446) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1447) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1448) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1449) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1450) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1451) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1452) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1453) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1454) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1455) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1456) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1457) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1458) (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1459) (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1460) (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1461) (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1462) (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1463) (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1464) (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1465) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1466) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1467) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1468) (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1469) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1470) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1471) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1472) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1473) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1474) (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1475) (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1476) (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1477) (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1478) (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1479) (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1480) (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1481) (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1482) (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1483) (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1484) (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1485) (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1486) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1487) (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1488) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1489) (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1490) (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1491) (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1492) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1493) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1494) (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1495) (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1496) (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1497) (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1498) (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1499) (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1500) (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1501) (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1502) (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1503) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1504) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1505) (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1506) (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1507) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1508) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1509) (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1510) (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)ambomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1511) (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1512) (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1513) (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1514) (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1515) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1516) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1517) (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1518) (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1519) (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1520) (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1521) (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1522) (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1523) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1524) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1525) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1526) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1527) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1528) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1529) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1530) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1531) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1532) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1533) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1534) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1535) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1536) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1537) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1538) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1539) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1540) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1541) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1542) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1543) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1544) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1545) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1546) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1547) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1548) (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1549) (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1550) (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1551) (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1552) (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1553) (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1554) (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1555) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1556) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1557) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1558) (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1559) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1560) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1561) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1562) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1563) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene. 1564) (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1565) (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1566) (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1567) (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicycle[3.3.0]-2-octene 1568) (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1569) (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1570) (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1571) (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1572) (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1573) (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1574) (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1575) (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1576) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1577) (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1578) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1579) (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1580) (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1581) (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1582) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1583) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1584) (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1585) (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1586) (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1587) (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1588) (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1589) (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1590) (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1591) (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1592) (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1593) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1594) (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1595) (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1596) (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1597) (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1598) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1599) (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1600) (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1601) (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1602) (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1603) (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1604) (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1605) (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1606) (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1607) (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1608) (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1609) (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1610) (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1611) (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1612) (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1613) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1614) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1615) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1616) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1617) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1618) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1619) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1620) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1621) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1622) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1623) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1624) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1625) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1626) (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1627) (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1628) (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1629) (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1630) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1631) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1632) (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1633) (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1634) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(E)-4-(m-talyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1635) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1636) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1637) (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1638) (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1639) (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1640) (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1641) (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1642) (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1643) (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1644) (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1645) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1646) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1647) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1648) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1649) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1650) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1651) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1652) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1653) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1654) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group 1655) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1656) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1657) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1658) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1659) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1660) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1661) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1662) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1663) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1664) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (4R,1E)-4-hydroxy-4-methyl-1-octenyl group 1665) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1666) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1667) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1668) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1669) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1670) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1671) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1672) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1673) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1674) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group 1675) (1S;5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1676) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1677) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1678) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1679) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1680) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1681) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1682) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1683) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1684) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group 1685) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1686) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1687) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1688) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1689) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1690) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1691) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1692) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1693) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1694) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group 1695) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1696) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1697) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1698) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1699) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-ociene 1700) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1701) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1702) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1703) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1704) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group 1705) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1706) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1707) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1708) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1709) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1710) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1711) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1712) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1713) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1714) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group 1715) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1716) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1717) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1718) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1719) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1720) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1721) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1722) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1723) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1724) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group 1725) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1726) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1727) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1728) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1729) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1730) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1731) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1732) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1733) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1734) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group 1735) (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1736) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1737) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1738) (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1739) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1740) (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1741) (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1742) (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1743) (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1744) compounds of compound numbers 1114 to 1194 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group at position 6 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by the (3R,1E)-3-hydroxy-1-octenyl group 1745) (1S,5S,6R,7S)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1746) (1S,5S,6R,7S)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1747) (1R,5R,6S,7S)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1748) (1R,5R,6S,7S)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1749) (1R,5R,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1750) (1R,5R,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1751) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-hydroxy-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1752) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1753) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1754) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1755) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1756) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1757) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1758) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1759) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1760) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1761) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1762) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1763) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1764) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1765) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1766) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1767) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1768) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1769) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-(3-ethylcyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1770) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-(3-ethylcyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1771) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1772) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1773) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1774) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1775) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1776) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1777) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1778) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1779) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1780) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1781) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1782) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1783) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1784) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1785) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1786) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1787) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1788) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1789) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1790) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1791) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1792) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1793) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1794) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1795) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1796) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1797) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1798) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(4-N,N-dimethylaminophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1799) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(4-N,N-dimethylaminophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1800) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(3-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1801) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(3-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1802) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(4-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1803) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(4-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1804) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1805) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1806) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1807) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1808) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1809) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1810) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1811) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1812) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1813) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1814) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1815) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1816) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1817) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1818) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1819) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1820) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E,5Z)-3-hydroxy-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1821) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E,5Z)-3-hydroxy-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1822) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1823) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1824) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1825) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1826) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4,4-dimethyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1827) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4,4-dimethyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1828) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1829) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1830) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1831) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene 1832) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1833) (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-1-octynyl]-7-hydroxybicyclo[3.3.0]-2-octene 1834) (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-1-octynyl]-7-hydroxybicyclo[3.3.0]-2-octene 1835) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1Z)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1836) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1Z)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1837) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxyoctyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1838) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxyoctyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1839) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-3-methyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene 1840) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-3-methyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene 1841) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-4,4-dimethyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene 1842) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-4,4-dimethyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene 1843) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-3-phenylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene 1844) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-3-phenylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene 1845) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-4-phenylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene 1846) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-4-phenylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene 1847) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-4-(m-tolyl)butyl]-7-hydroxybicyclo[3.3.0]-2-octene 1848) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-4-(m-tolyl)butyl]-7-hydroxybicyclo[3.3.0]-2-octene 1849) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-3-cyclopentylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene 1850) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-3-cyclopentylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene 1851) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1852) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1853) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-hydroxy-4-butyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1854) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-butyl-1,5-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1855) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-butyl-1,5-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1856) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-cyclopentyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1857) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-cyclopentyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1858) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-cyclohexyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1859) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-cyclohexyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1860) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1861) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1862) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-(1-hydroxycyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1863) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-(1-hydroxycyclohexyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1864) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1865) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1866) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1867) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-1,3-octadienyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1868) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,5S)-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1869) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,5R)-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1870) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E,5S)-5-methyl-1,3-nonadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1871) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E,5R)-5-methyl-1,3-nonadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1872) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,4R)-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1873) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,4S)-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1874) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-methyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1875) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,4R)-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1876) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,4S)-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1877) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-ethyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1878) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-butyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1879) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,5Z)-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1880) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E,5Z)-1,3,5-octatrienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1881) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-cyclopentyliden-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1882) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-cyclohexyliden-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1883) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-2-phenylvinyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1884) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-2-(o-tolyl)vinyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1885) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-2-(m-tolyl)vinyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1886) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-2-(p-tolyl)vinyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1887) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-phenyl-1-propenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1888) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-phenyl-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1889) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-phenyl-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1890) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-phenyl-3-methyl-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1891) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-(o-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1892) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1893) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-(p-tolyl)-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1894) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-(m-tolyl)-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1895) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1896) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-5-(m-tolyl)-1,3-pentadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1897) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4,4-bisphenylsulfonyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1898) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-5-(m-tolyl)-1,3-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene 1899) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(4-phenoxybutyl)-7-hydroxy bicyclo[3.3.0]-2-octene 1900) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-propenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1901) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-butenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1902) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-pentenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1903) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-hexenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1904) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-heptenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1905) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-octenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1906) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-nonenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1907) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-decenyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1908) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-3-oxo-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1909) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-3-oxo-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1910) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1911) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(5S,1E)-3-oxo-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1912) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(5R,1E)-3-oxo-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1913) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1914) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1915) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1916) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1917) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1918) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1919) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1920) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1921) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1922) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1923) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1924) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1925) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1926) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1927) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1928) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1929) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-hydroxymethyl-7-hydroxy bicyclo[3.3.0]-2-octene 1930) (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxyethyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1931) (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxyethyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1932) (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxypentyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1933) (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxypentyl]-7-hydroxy bicyclo[3.3.0]-2-octene 1934) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxy-1-methylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene 1935) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxy-1-methylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene 1936) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R,2E)-1-hydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1937) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S,2E)-1-hydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1938) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R,3S,2E)-1,3-dihydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1939) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S,3S,2E)-1,3-dihydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1940) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R,3S,2E)-1,3-dihydroxy-4-cyclopentyl-2-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1941) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S,3S,2E)-1,3-dihydroxy-4-cyclopentyl-2-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1942) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R,3S,2E)-1,3-dihydroxy-5-phenyl-2-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1943) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S,3S,2E)-1,3-dihydroxy-5-phenyl-2-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1944) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxy-2-pentynyl]-7-hydroxybicyclo[3.3.0]-2-octene 1945) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxy-2-pentynyl]-7-hydroxybicyclo[3.3.0]-2-octene 1946) (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxy-5-phenoxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene 1947) (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxy-5-phenoxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene 1948) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxyphenylmethyl]-7-hydroxybicyclo[3.3.0]-2-octene 1949) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxyphenylmethyl]-7-hydroxybicyclo[3.3.0]-2-octene 1950) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(o-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1951) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(o-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1952) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(m-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1953) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(m-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1954) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(p-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1955) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(p-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1956) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(4-methoxyphenyl) methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1957) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(4-methoxyphenyl) methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1958) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(4-N,N-dimethylamino phenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1959) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(4-N,N-dimethylamino phenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1960) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(3-chlorophenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1961) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(3-chlorophenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene 1962) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-formyl-7-hydroxybicyclo[3.3.0]-2-octene 1963) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-acetyl-7-hydroxybicyclo[3.3.0]-2-octene 1964) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-benzoyl-7-hydroxybicyclo[3.3.0]-2-octene 1965) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(o-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene 1966) (1S,SS,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(m-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene 1967) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(p-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene 1968) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(4-methoxyphenylcarbonyl)-7-hydroxy bicyclo[3.3.0]-2-octene 1969) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(4-N,N-dimethylaminophenyl carbonyl)-7-hydroxybicyclo[3.3.0]-2-octene 1970) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(3-chlorophenylcarbonyl)-7-hydroxy bicyclo[3.3.0]-2-octene 1971) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-phenylvinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 1972) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(4-methoxyphenyl)vinyl carbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 1973) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(4-N,N-dimethylaminophenyl) vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 1974) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(3-chlorophenyl)vinyl carbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 1975) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(2-thienyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 1976) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(4-pyridyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene 1977) compounds of compound numbers 1655 to 1976 of the examples given above, wherein the 5-N,N-dimethylaminopentyl group, which is a substitution group at position 3 in the structure of the bicyclo[3.3.0]-2-octene cycle, has been replaced by either of the 5-aminopentyl group, the 5-N,N-diethylaminopentyl group, the 5-N-(3-hydroxypropyl)aminopentyl group, the 5-N-(4-pyridylmethyl)aminopentyl group, the 5-N,N-diisopropylaminopentyl group, the 5-(1-pyrrolidinyl)pentyl group or the 5-piperidinopentyl group, the 5-morpholinopentyl group 1978) (1S,2R,3R,5S)-7-[(E)-5-aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxy bicyclo[3.3.0]octane 1979) (1S,2R,3R,5S)-7-[(E)-5-N-methylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1980) (1S,2R,3R,5S)-7-[(E)-5-N-ethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1981) (1S,2R,3R,5S)-7-[(E)-5-N-propylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1982) (1S,2R,3R,5S)-7-[(E)-5-N-isopropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1983) (1S,2R,3R,5S)-7-[(E)-5-N-butylaminopeatylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1984) (1S,2R,3R,5S)-7-[(E)-5-N-t-butylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1985) (1S,2R,3R,5S)-7-[(E)-5-N-phenylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1986) (1S,2R,3R,5S)-7-[(E)-5-N-benzylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1987) (1S,2R,3R,5S)-7-[(E)-5-N-(4-pyridylmethyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1988) (1S,2R,3R,5S)-7-[(E)-5-(1-pyrrolidinyl)pentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1989) (1S,2R,3R,5S)-7-[(E)-5-piperidinopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1990) (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1991) (1S,2R,3R,5S)-7-[(E)-5-(4-N-methyl-1-piperazinyl)pentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1992) (1S,2R,3R,5S)-7-[(E)-5-N-(2-pyridyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1993) (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1994) (1S,2R,3R,5S)-7-[(E)-5-N,N-diethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1995) (1S,2R,3R,5S)-7-[(E)-5-N,N-dipropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1996) (1S,2R,3R,5S)-7-[(E)-5-N,N-diisopropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1997) (1S,2R,3R,5S)-7-[(E)-5-N,N-dibutylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1998) (1S,2R,3R,5S)-7-[(E)-5-N-t-butyl-N-methylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 1999) (1S,2R,3R,5S)-7-[(E)-5-N-(2-hydroxyethyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2000) (1S,2R,3R,5S)-7-[(E)-5-N-(3-hydroxypropyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicydo[3.3.0]octane 2001) (1S,2R,3R,5S)-7-[(E)-4-aminobutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxy bicyclo[3.3.0]octane 2002) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylaminobutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2003) (1S,2R,3R,5S)-7-[(E)-6-aminohexylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxy bicyclo[3.3.0]octane 2004) (1S,2R,3R,5S)-7-[(E)-6-N,N-dimethylaminohexylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2005) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-diisopropylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2006) (1S,2R,3R,5S)-7-[(E)-2-(2-N-t-butyl-N-methylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2007) (1S,2R,3R,5S)-7-[(E)-2-[2-(1-pyrrolidinyl)ethyl]oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2008) (1S,2R,3R,5S)-7-[(E)-2-(2-piperidinoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2009) (1S,2R,3R,5S)-7-[(E)-2-(2-morpholinoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2010) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)thioethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2011) (1S,2R,3R,5S)-7-[(E)-2-N-(2-N,N-dimethylaminoethyl)aminoethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2012) (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)oxymethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2013) (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)thiomethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2014) (1S,2R,3R,5S)-7-[(E)-N-(2-N,N-dimethylaminoethyl)aminomethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2015) (1S,2R,3R,5S)-7-[(E)-5-aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2016) (1S,2R,3R,5S)-7-[(E)-5-N-methylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2017) (1S,2R,3R,5S)-7-[(E)-5-N-ethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2018) (1S,2R,3R,5S)-7-[(E)-5-N-propylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2019) (1S,2R,3R,5S)-7-[(E)-5-N-isopropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2020) (1S,2R,3R,5S)-7-[(E)-5-N-butylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2021) (1S,2R,3R,5S)-7-[(E)-5-N-t-butylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2022) (1S,2R,3R,5S)-7-[(E)-5-N-phenylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2023) (1S,2R,3R,5S)-7-[(E)-5-N-benzylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2024) (1S,2R,3R,5S)-7-[(E)-5-N-(4-pyridylmethyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2025) (1S,2R,3R,5S)-7-[(E)-5-(1-pyrrolidinyl)pentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2026) (1S,2R,3R,5S)-7-[(E)-5-piperidinopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2027) (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2028) (1S,2R,3R,5S)-7-[(E)-5-(4-N-methyl-1-piperazinyl)pentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2029) (1S,2R,3R,5S)-7-[(E)-5-N-(2-pyridyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2030) (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2031) (1S,2R,3R,5S)-7-[(E)-5-N,N-diethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2032) (1S,2R,3R,5S)-7-[(E)-5-N,N-dipropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2033) (1S,2R,3R,5S)-7-[(E)-5-N,N-diisopropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2034) (1S,2R,3R,5S)-7-[(E)-5-N,N-dibutylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2035) (1S,2R,3R,5S)-7-[(E)-5-N-t-butyl-N-methylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2036) (1S,2R,3R,5S)-7-[(E)-5-N-(2-hydroxyethyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2037) (1S,2R,3R,5S)-7-[(E)-5-N-(3-hydroxypropyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2038) (1S,2R,3R,5S)-7-[(E)-4-aminobutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2039) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylaminobutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2040) (1S,2R,3R,5S)-7-[(E)-6-aminohexylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2041) (1S,2R,3R,5S)-7-[(E)-6-N,N-dimethylaminohexylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2042) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2043) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-diisopropylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2044) (1S,2R,3R,5S)-7-[(E)-2-(2-N-t-butyl-N-methylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2045) (1S,2R,3R,5S)-7-[(E)-2-[2-(1-pyrrolidinyl)ethyl]oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2046) (1S,2R,3R,5S)-7-[(E)-2-(2-piperidinoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2047) (1S,2R,3R,5S)-7-[(E)-2-(2-morpholinoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2048) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)thioethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2049) (1S,2R,3R,5S)-7-[(E)-2-N-(2-N,N-dimethylaminoethyl)aminoethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2050) (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)oxymethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2051) (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)thiomethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2052) (1S,2R,3R,5S)-7-[(E)-N-(2-N,N-dimethylaminoethyl)aminomethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane 2053) (1S,2R,3R,5S)-7-[(E)-5-aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2054) (1S,2R,3R,5S)-7-[(E)-5-N-methylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2055) (1S,2R,3R,5S)-7-[(E)-5-N-ethylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2056) (1S,2R,3R,5S)-7-[(E)-5-N-propylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2057) (1S,2R,3R,5S)-7-[(E)-5-N-isopropylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2058) (1S,2R,3R,5S)-7-[(E)-5-N-butylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2059) (1S,2R,3R,5S)-7-[(E)-5-N-t-butylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2060) (1S,2R,3R,5S)-7-[(E)-5-N-phenylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2061) (1S,2R,3R,5S)-7-[(E)-5-N-benzylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2062) (1S,2R,3R,5S)-7-[(E)-5-N-(4-pyridylmethyl)aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2063) (1S,2R,3R,5S)-7-[(E)-5-(1-pyrrolidinyl)pentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2064) (1S,2R,3R,5S)-7-[(E)-5-piperidinopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2065) (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2066) (1S,2R,3R,5S)-7-[(E)-5-(4-N-methyl-1-piperazinyl)pentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2067) (1S,2R,3R,5S)-7-[(E)-5-N-(2-pyridyl)aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2068) (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2069) (1S,2R,3R,5S)-7-[(E)-5-N,N-diethylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2070) (1S,2R,3R,5S)-7-[(E)-5-N,N-dipropylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2071) (1S,2R,3R,5S)-7-[(E)-5-N,N-diisopropylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2072) (1S,2R,3R,5S)-7-[(E)-5-N,N-dibutylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2073) (1S,2R,3R,5S)-7-[(E)-5-N-t-butyl-N-methylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2074) (1S,2R,3R,5S)-7-[(E)-5-N-(2-hydroxyethyl)aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2075) (1S,2R,3R,5S)-7-[(E)-5-N-(3-hydroxypropyl)aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2076) (1S,2R,3R,5S)-7-[(E)-4-aminobutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2077) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylaminobutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2078) (1S,2R,3R,5S)-7-[(E)-6-aminohexylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2079) (1S,2R,3R,5S)-7-[(E)-6-N,N-dimethylaminohexylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2080) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2081) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-diisopropylaminoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2082) (1S,2R,3R,5S)-7-[(E)-2-(2-N-t-butyl-N-methylaminoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2083) (1S,2R,3R,5S)-7-[(E)-2-[2-(1-pyrrolidinyl)ethyl]oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2084) (1S,2R,3R,5S)-7-[(E)-2-(2-piperidinoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2085) (1S,2R,3R,5S)-7-[(E)-2-(2-morpholinoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2086) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)thioethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2087) (1S,2R,3R,5S)-7-[(E)-2-N-(2-N,N-dimethylaminoethyl)aminoethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2088) (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)oxymethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2089) (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)thiomethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2090) (1S,2R,3R,5S)-7-[(E)-N-(2-N,N-dimethylaminoethyl)aminomethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2091) (1S,2R,3R,5S)-7-[(E)-5-aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2092) (1S,2R,3R,5S)-7-[(E)-5-N-methylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2093) (1S,2R,3R,5S)-7-[(E)-5-N-ethylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2094) (1S,2R,3R,5S)-7-[(E)-5-N-propylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2095) (1S,2R,3R,5S)-7-[(E)-5-N-isopropylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2096) (1S,2R,3R,5S)-7-[(E)-5-N-butylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2097) (1S,2R,3R,5S)-7-[(E)-5-N-t-butylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2098) (1S,2R,3R,5S)-7-[(E)-5-N-phenylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2099) (1S,2R,3R,5S)-7-[(E)-5-N-benzylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2100) (1S,2R,3R,5S)-7-[(E)-5-N-(4-pyridylmethyl)aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2101) (1S,2R,3R,5S)-7-[(E)-5-(1-pyrrolidinyl)pentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2102) (1S,2R,3R,5S)-7-[(E)-5-piperidinopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2103) (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2104) (1S,2R,3R,5S)-7-[(E)-5-(4-N-methyl-1-piperazinyl)pentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane. 2105) (1S,2R,3R,5S)-7-[(E)-5-N-(2-pyridyl)aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2106) (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2107) (1S,2R,3R,5S)-7-[(E)-5-N,N-diethylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2108) (1S,2R,3R,5S)-7-[(E)-5-N,N-dipropylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2109) (1S,2R,3R,5S)-7-[(E)-5-N,N-diisopropylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2110) (1S,2R,3R,5S)-7-[(E)-5-N,N-dibutylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2111) (1S,2R,3R,5S)-7-[(E)-5-N-t-butyl-N-methylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2112) (1S,2R,3R,5S)-7-[(E)-5-N-(2-hydroxyethyl)aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2113) (1S,2R,3R,5S)-7-[(E)-5-N-(3-hydroxypropyl)aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2114) (1S,2R,3R,5S)-7-[(E)-4-aminobutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2115) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylaminobutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2116) (1S,2R,3R,5S)-7-[(E)-6-aminohexylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2117) (1S,2R,3R,5S)-7-[(E)-6-N,N-dimethylaminohexylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2118) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2119) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-diisopropylaminoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2120) (1S,2R,3R,5S)-7-[(E)-2-(2-N-t-butyl-N-methylaminoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2121) (1S,2R,3R,5S)-7-[(E)-2-[2-(1-pyrrolidinyl)ethyl]oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2122) (1S,2R,3R,5S)-7-[(E)-2-(2-piperidinoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2123) (1S,2R,3R,5S)-7-[(E)-2-(2-morpholinoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2124) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)thioethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2125) (1S,2R,3R,5S)-7-[(E)-2-N-(2-N,N-dimethylaminoethyl)aminoethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2126) (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)oxymethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2127) (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)thiomethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2128) (1S,2R,3R,5S)-7-[(E)-N-(2-N,N-dimethylaminoethyl)aminomethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane 2129) compounds of compound numbers 1978 to 2014 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group bonded to the carbon at position 12 of the prostacyclin carbon identification number, has been replaced by either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (E)-4-(m-tolyl)-1-butenyl group, the (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group or the (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group, the 2-(1-hydroxycyclohexyl)ethynyl group 2130) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-aminobutyl)-1H-cyclopenta[b]benzofuran 2131) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran 2132) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-ethylaminobutyl)-1H-cydopenta[b]benzofuran 2133) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydrbxy-1-octenyl]-5-(4-N-propylaminobutyl)-1H-cyclopenta[b]benzofuran 2134) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-isopiopylaminobutyl)-1H-cyclopenta[b]benzofuran 2135) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-butylaminobutyl)-1H-cyclopenta[b]benzofuran 2136) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-t-butylaminobutyl)-1H-cyclopenta[b]benzofuran 2137) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-phenylaminobutyl)-1H-cyclopenta[b]benzofuran 2138) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-benzylaminobutyl)-1H-cyclopenta[b]benzofuran 2139) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-N-(4-pyridylmethyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2140) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-(1-pyrrolidinyl)butyl]-1H-cyclopenta[b]benzofuran 2141) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-piperidinobutyl)-1H-cyclopenta[b]benzofuran 2142) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-morpholinobutyl)-1H-cyclopenta[b]benzofuran 2143) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-(4-N-methyl-1-piperazinyl)butyl]-1H-cyclopenta[b]benzofuran 2144) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-N-(2-pyridyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2145) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran 2146) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N,N-diethylaminobutyl)-1H-cyclopenta[b]benzofuran 2147) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N,N-dipropylaminobutyl)-1H-cyclopenta[b]benzofuran 2148) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N,N-diisopropylaminobutyl)-1H-cyclopenta[b]benzofuran 2149) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N,N-dibutylaminobutyl)-1H-cyclopenta[b]benzofuran 2150) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-t-butyl-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran 2151) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-N-(2-hydroxyethyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2152) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-N-(3-hydroxypropyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2153) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-aminopropyl)-1H-cyclopenta[b]benzofuran 2154) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N,N-dimethylaminopropyl)-1H-cyclopenta[b]benzofuran 2155) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(5-aminopentyl)-1H-cyclopenta[b]benzofuran 2156) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(5-N,N-dimethylaminopentyl)-1H-cyclopenta[b]benzofuran 2157) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N,N-dimethylaminopropyloxy)-1H-cyclopenta[b]benzofuran 2158) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-aminobutyl)-1H-cyclopenta[b]benzofuran 2159) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran 2160) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-ethylaminobutyl)-1H-cyclopenta[b]benzofuran 2161) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-propylaminobutyl)-1H-cyclopenta[b]benzofuran 2162) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-isopropylaminobutyl)-1H-cyclopenta[b]benzofuran 2163) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-butylaminobutyl)-1H-cyclopenta[b]benzofuran 2164) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-t-butylaminobutyl)-1H-cyclopenta[b]benzofuran 2165) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-phenylaminobutyl)-1H-cyclopenta[b]benzofuran 2166) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-benzylaminobutyl)-1H-cyclopenta[b]benzofuran 2167) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(4-pyridylmethyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2168) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-(1-pyrrolidinyl)butyl]-1H-cyclopenta[b]benzofuran 2169) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-piperidinobutyl)-1H-cyclopenta[b]benzofuran 2170) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-morpholinobutyl)-1H-cyclopenta[b]benzofuran 2171) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-(4-N-methyl-1-piperazinyl)butyl]-1H-cyclopenta[b]benzofuran 2172) (1R,2R,3a5,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(2-pyridyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2173) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran 2174) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-diethylaminobutyl)-1H-cyclopenta[b]benzofuran 2175) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dipropylaminobutyl)-1H-cyclopenta[b]benzofuran 2176) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-diisopropylaminobutyl)-1H-cyclopenta[b]benzofuran 2177) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dibutylaminobutyl)-1H-cyclopenta[b]benzofuran 2178) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-t-butyl-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran 2179) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(2-hydroxyethyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2180) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(3-hydroxypropyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2181) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-aminopropyl)-1H-cyclopenta[b]benzofuran 2182) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylaminopropyl)-1H-cyclopenta[b]benzofuran 2183) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(5-aminopentyl)-1H-cyclopenta[b]benzofuran 2184) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(5-N,N-dimethylaminopentyl)-1H-cyclopenta[b]benzofuran 2185) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylaminopropyloxy)-1H-cyclopenta[b]benzofuran 2186) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-aminobutyl)-1H-cyclopenta[b]benzofuran 2187) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran 2188) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-ethylaminobutyl)-1H-cyclopenta[b]benzofuran 2189) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-propylaminobutyl)-1H-cyclopenta[b]benzofuran 2190) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-isopropylaminobutyl)-1H-cyclopenta[b]benzofuran 2191) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-butylaminobutyl)-1H-cyclopenta[b]benzofuran 2192) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-t-butylaminobutyl)-1H-cyclopenta[b]benzofuran 2193) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-phenylaminobutyl)-1H-cyclopenta[b]benzofuran 2194) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-benzylaminobutyl)-1H-cyclopenta[b]benzofuran 2195) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(4-pyridylmethyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2196) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-(1-pyrrolidinyl)butyl]-1H-cyclopenta[b]benzofuran 2197) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-piperidinobutyl)-1H-cyclopenta[b]benzofuran 2198) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-morpholinobutyl)-1H-cyclopenta[b]benzofuran 2199) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-(4-N-methyl-1-piperazinyl)butyl]-1H-cyclopenta[b]benzofuran 2200) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(2-pyridyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2201) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran 2202) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-diethylaminobutyl)-1H-cyclopenta[b]benzofuran 2203) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dipropylaminobutyl)-1H-cyclopenta[b]benzofuran 2204) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-diisopropylaminobutyl)-1H-cyclopenta[b]benzofuran 2205) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dibutylaminobutyl)-1H-cyclopenta[b]benzofuran 2206) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-t-butyl-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran 2207) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(2-hydroxyethyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2208) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(3-hydroxypropyl)aminobutyl]-1H-cyclopenta[b]benzofuran 2209) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-aminopropyl)-1H-cyclopenta[b]benzofuran 2210) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylaminopropyl)-1H-cyclopenta[b]benzofuran 2211) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(5-aminopentyl)-1H-cyclopenta[b]benzofuran 2212) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(5-N,N-dimethylaminopentyl)-1H-cyclopenta[b]benzofuran 2213) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylaminopropyloxy)-1H-cyclopenta[b]benzofuran 2214) compunds of compound numbers 2130 to 1256 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group bonded to the carbon at position 12 of the prostacyclin carbon identification number, has been replaced by either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (E)-4-(m-tolyl)-1-butenyl group, the (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group, the (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group or the (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl 2215) (1S,2R,3R,5S)-7-[(Z)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2216) (1R,5S,7R,8R)-3-(5-N,N-dimethylaminopentyl)-8-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 2217) (1S,2R,3R,5S,7R)-7-(5-N,N-dimethylaminopentyl)-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 2218) (1S,2R,3R,5S,7R)-7-[2-(2-N,N-dimethylaminoethoxy)ethyl]-2-[(3R,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-3-hydroxybicyclo[3.3.0]octane 2219) (1S,3S,5R,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-oxabicyclo[3.3.0]octane 2220) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-oxabicyclo[3.3.0]-3-octen 2221) (1S,5R,6R,7R)-3-[(Z)-5-N,N-dimethylaminopentylidene]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-4-oxo-2-oxabicyclo[3.3.0]octane 2222) (1S,3S,5R,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-thiabicyclo[3.3.0]octane 2223) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-o-ctenyl]-7-hydroxy-2-azabicyclo[3.3.0]-2-octene 2224) (1S,3S,5R,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-azabicyclo[3.3.0]octane 2225) compunds of compound numbers 2215 to 1224 of the examples given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a substitution group bonded to the carbon at position 12 of the prostacyclin carbon identification number, has been replaced by either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the (E)-4-(m-tolyl)-1-butenyl group, the (3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group, the (3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group, the (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group, the (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the (3R,1E)-3-hydroxy-3-phenyl-1-propenylgroup or the (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group 2226) compunds of compound numbers 1 to 174, 262 to 435, 523 to 532, 543 to 728, 855 to 1104, 1105 to 1284, 1375 to 1554, 1645 to 1654, 1665 to 1850 and 1977 to 2225 of the examples given above, wherein the hydroxyl groups/group, which are/is bonded to the carbon at position 11 and/or at position 15 of the prostacyclin carbon identification number, has/have been substituted for either of the acetoxy group, t-butyldimethylsilyloxy group, trimethylsilyloxy group or the tetrahydropyran-2-yloxy group 2227) compunds of compound numbers 175 to 261, 533 to 542, 729 to 743, 855, 1008, 1093, 1104, 1285 to 1374, 1655 to 1664, 1851 to 1865, 1977, 2129, 2214 and 2225 of the examples given above, whrein the hydroxyl groups/group, which are/is bonded to the carbon at position 11 and/or at position 16 of the prostacyclin carbon identification number, has/have been substituted for either of the acetoxy group, the t-butyldimethylsilyloxy group, the trimethylsilyloxy group or the tetrahydropyran-2-yloxy group 2228) compunds of compound numbers 436 to 522, 744 to 855, 1008, 1093, 1104, 1555 to 1644, 1866 to 1977, 2129, 2214 and 2225of the examples given above, whrein the hydroxyl group, which is bonded to the carbon at position 11 of the prostacyclin carbon identification number, has been substituted for either of the acetoxy group, the t-butyldimethylsilyloxy group, the trimethylsilyloxy group or the tetrahydropyran-2-yloxy group 2229) (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane The nitrogen-containing compound represented by the above Formula (1) has an activity for the remedy of neural damage. Therefore, the nitrogen-containing compound of the present invention can be used as an agent for the treatment of disorders due to neural damage, or and agent for the treatment of lesion of nerves due to external injuries. Among the nitrogen-containing compound represented by the above Formula (1) of the present invention, those having an amido group at the extremity of the α-chain of prostacyclin analog structure, in other words, those whose A 4 in the above Formula (1) is a carbonyl group are derived from functional groups such as a carboxyl group, an alkoxycarbonyl group or a cyano group, by the method described in pages 137 through 173 of the "Fourth Edition of the Experimental Chemistry Course" by the Chemical Society of Japan, Volume 220 (Maruzen Co., Ltd.). In other words, the target amide can be obtained by inserting a functional group such as a carboxyl group, an alkoxycarbonyl group or a cyano group at the site corresponding to the α-chain of the synthetic intermediate having the prostacyclin analog structure indicated by G in the above Formula (1), and by adding the appropriate chemical modification. For example, as indicated in Scheme 1 below, by converting the carboxyl group at position 1 of an isocarbacyclin into an imidazolylcarbonyl group using 1,1'-carbonyldiimidazole, then reacting with an amine to convert into an amide group, the target amide can be obtained. Usually, the reaction uses polar aprotic solvents such as dimethylformamide, N-methylpyrrolidone, hexamethyl phosphoric triamide, dimethyl sulfoxide. However, dimethylformamide and N-methylpyrrolidone are used preferably. The reaction is performed at a temperature range of 0 to 100°C with a timeframe of 10 minutes to 24 hours. However, it is performed preferably at a temperature range of 10 to 60°C with a timeframe of 15 minutes to 18 hours. Among the nitrogen-containing compound represented by the above Formula (1) of the present invention, those having an amino group at the extremity of the α-chain of prostacyclin analog structure, in other words, those whose A 4 in the above Formula (1) represents a single bond, or an aliphatic hydrocarbon group having 1 to 3 carbon atoms, are derived from functional groups such as an amide group, an imino group, a halogen group, a carbonyl group, a cyano group or an azide group by the method described in pages 279 through 317 of the "Fourth Edition of the Experimental Chemistry Course" by the Chemical Society of Japan, Volume 20 (Maruzen Co., Ltd.). In other words, the target amines can be obtained by inserting a functional group such as an amide group, an imino group, a halogen group, a carbonyl group, a cyano group or an azide group at the site corresponding to the α-chain of the synthetic intermediate having the prostacyclin analog structure indicated by G in the above Formula (1), and by adding an adequate chemical modification. For example, as indicated in Scheme 2 below, from an amide obtained using a method, for example, indicated in Scheme 1, the target amine can be obtained with reducing agents such as lithium aluminium hydride or borane. Usually, the reaction uses ether solvents such as tetrahydrofurane, dioxane, dimethoxyethane, and preferably uses tetrehydrofurane. The reaction is performed at a temperature range of 0 to 100°C and with a timeframe of 10 minutes to 24 hours. However, it is performed preferably at a temperature range of 10 to 60°C with a timeframe of 15 minutes to 18 hours. In addition, modifications at sites on the cyclic structure and at sites on the ω-chain of the nitrogen-containing compound represented by the above Formula (1) of the present invention can be achieved following routes indicated for example in Scheme 3, Scheme 4 and Scheme 5, but are not limited to the these. [In the above, R 45 , R 55 , R 65 in Scheme 3, Scheme 4 and Scheme 5 are functional groups chosen among those exemplified by R 4 , R 5 , R 6 , respectively.] The nitrogen-containing compound of the present invention is produced by combining the modifications of the sites on the α-chain, the sites on the cyclic structure and the site on the ω-chain. Since the nitrogen-containing compound of the present invention has an activity for the remedy of nerve damage, it can be used as an agent for the treatment of disorders caused by nerve damage, or for the treatment of lesions of the nerves due to external injuries. There are no particular limitations on the scope of application of such an agent for treating neural damage or lesion of nerves due to external injuries. The drug agent of the present invention is particularly useful for mammals, and can be suitably used for livestock, laboratory animals, pets and humans, among others. The agent for the treatment of disorders caused by nerve damage, or for the treatment of lesions of the nerves due to external injuries of the present invention, can be used for the treatment of animal or human disorders or lesions. There are no particular limitations on the scope of disorders, which must be caused by a neural damage. The following can be cited as concrete examples, 1) Neuro-degenerative disorders such as Alzheimer's disease, Pick's disease, Lewy body disease, Parkinson's disease, Huntington's chorea, spinocerebellar degeneration and amyotrophic lateral sclerosis, 2) demyelinating disorders such as acute disseminated encephalomyelitis and multiple sclerosis, 3) metabolic disorders such as brain lipidosis and Wilson's Disease, 4) infectious disorders such as meningitis and Creutzfeld-Jacob disease, 5) peripheral neural damage such as polyneuritis and Guillain-Barre Syndrome, 6) cerebrovascular disorders such as cerebral infarction and transient ischemia, 7) nervous disorders (neuropathies) associated with diabetes and renal diseases and 8) brain tumors. However, it is preferably used in disorders cited from 1) through 5). No particular restriction exists on the method of administration. However, oral administration, percutaneous administration, nasal administration, intravenous injection, intraperitoneal administration, rectal administration or intracerebroventricular administration are preferred. For the clinical application of the nitrogen-containing compound or the salts thereof of the present invention, or clathrate compounds, it is desirable to produce a pharmaceutical preparation formed by the nitrogen-containing compound and a pharmaceutically accepted solid or liquid carrier, and to further add diluents, in other words additives such as excipients and stabilizers, as necessary. The amine injectable preparation of the present invention to be used for therapeutic administration must be sterile. Sterilization can be easily achieved by filtration through a sterilization filter membrane such as a membrane filter haying a pore diameter of 0.2µm. In such pharmaceutical composition, the proportion of the above-mentioned active ingredient with respect to the constituents of the carrier can be modulated, for example, between 0.000001 and 90% W/W. Therapeutic effective dose depends on the method of administration, age, and the disorder considered, however, 0.01µg to 1000mg/day/individual is possible, and 0.01µg to 10mg/day/individual is preferred. For each administration route, it is desirable to determine the efficacy of absorption into the body for each compound, separately. Concerning the formulation and the administration form, oral administration is possible by making formulations such as granules, subtle granules, powders, pills, tablets, capsules or liquids, or, parenteral administration is possible by making agents for local applications such as suppositories, aerosols, or ointments and skin patches. As injectable agents, intravenous administration, intra-arterial administration, intramuscular administration, subcutaneous administration are possible. In addition, prior to use, powders for injectable solution can be prepared. In addition, nasal administration, intraperitoneal administration, rectal administration or intracerebroventricular administration are possible. Organic or inorganic, solid or liquid carriers or diluents can also be used to prepare the nitrogen-containing compound of the current invention to serve as a pharmaceutical preparation suited for oral, enteral or parenteral administration. Binding agents such as acacia, corn starch, or gelatin, excipients such as microcrystalline cellulose, disintegrants such as cornstarch and alginic acid, lubricants such as magnesium stearate, and sweeteners such as saccharose and lactose can be cited as representative carriers or diluents entering in the composition of tablets and capsules. If the formulation is a capsule, in addition to the above substances, liquid carriers such as lipid oils may be included. Various sorts of other substances may be used as coating agents or agents for improving the physical state of the dose units. Sterile compositions for injection, may be formulated according to a pharmaceutical method of the art. For example, it is desirable to dissolve or suspend the active compound in an excipient such as water or natural vegetal oil or synthetic lipid excipient such as ethyl oleate. It is also possible to include buffers such as citrate, acetate, phosphate, and antioxydants such as ascorbate, according to accepted pharmaceutical methods. The tablet form can be obtained by the usual method, for example it can be made by using excipients such as lactose, starch or crystalline cellulose; binding agents such as carboxymethyl cellulose, methyl cellulose or polyvinyl pyrrolidone; disintegrants such as sodium alginate, sodium bicarbonate and sodium lauryl sulfate. Likewise, pills, powders, granules can be made by the usual method using the above-mentioned excipients. Liquid agents and suspensions can be made by the usual method using, for example, glycerin esters such as tricaprilyn or triacetin, or alcohols such as ethanol. Capsules can be obtained by filling capsules, for instance, made of gelatin with granules, powders, or liquids. As a formulation for oral administration, the nitrogen-containing compound of the present invention, can be converted into a cyclodextrin clathrate compound. The clathrate can be prepared by adding a solution made by dissolving cyclodextrin in water and/or an organic solvent capable of mixing easily with water, to a solution made by dissolving the nitrogen-containing compound in an organic solvent capable of mixing easily with water. The mixture is heated, then vacuum concentrated under refrigeration, filtered or decanted to separate the product and isolate the target cyclodextrin clathrate compound. The proportion of organic solvent and water varies with the solubility of the starting material and of the product. It is desirable that the temperature when preparing cyclodextrin clathrate compound does not exceed 70°C. α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin or any combination of the above, can be used for the preparation of cyclodextrin clathrate compound. The stability of the nitrogen-containing compound can be increased by a conversion into a cyclodextrin clathrate compound As formulation for subcutaneous, intramuscular and intravenous administration, injectable agents exist in the form of aqueous and non-aqueous solutions. For example, physiological saline can be used for aqueous solutions. For non-aqueous solution, for example, propyleneglycol, polyethylene glycol, olive oil, ethyl oleate can be used, and anticeptic agents and stabilizers can be added to the above, as needed. Injectable agents are sterilized by suitably performing treatments such as filtration through bacterial retention filters or mixing with bactericides. As formulations for percutaneous administration, ointments and creams can be cited as examples. Ointments can be made by the usual method with fats such as castor oil and olive oil, and emulsifiers such as diethyleneglycol, sorbitan monofatty acid ester; creams can be made using vaseline with grease oil and emulsifiers such as diethyleneglycol, sorbitan monofatty acid ester For rectal administration, a usual suppository such as a gelatin soft capsule may be used. Preparations for parenteral administration can be administered as emulsions. In other words, water is added to a homogenous solution made of vegetal oils such as soybean oil, phospholipids such as lecithins and the nitrogen-containing compound of the present invention, and homogenized by homogenizers such as, for example, pressure-injection homogenizer or ultrasonic homogenizer, to give lipid emulsion which can also be used as an injectable agent. Embodiments In the following, the present invention will be explained more concretely by giving examples and reference examples. However, the present invention is not limited to these examples and reference examples. [Reference example 1] Preparation of (1S,5S,6R,7R)-3 -(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 73mg of (1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene was taken and dissolved in 2mL of dimethylformamide. After addition of 49mg of 1,1'-carbonyldiimidazole, it was stirred at 50°C for 1 hour. It was then cooled to ambient temperature, 5mL of 25% ammonium hydroxide in water was added, and stirred for 1 hour. An aqueous solution saturated with potassium hydrogen sulfate was added and extracted with ethyl acetate. The organic layer was washed with an aqueous solution saturated with sodium bicarbonate, then with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, it was subjected to a silicagel column chromatography, to obtain 29mg of the compound presented in the title (40% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.91 (brt, 3H, J=7.1Hz), 1.17 (s, 3H), 1.2-1.7 (m, 15H), 1.8-2.5 (m, 11H), 2.9-3.1 (m, 1H), 3.7-3.9 (m, 1H), 5.30 (brs, 1H), 5.3-5.5 (m, 1H), 5.5-5.7 (m, 1H). [Reference example 2] The compound shown in Table 1 was obtained with a method identical to Reference example 1. [Reference example 3] Preparation of (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 59mg of (1S,5S,6R,7R)-3-(4-methoxycarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene was taken and dissolved in 3mL acetonitrile, under stirring, 10mL of 25% ammonium hydroxide in water was added and stirred for 6 days. After concentration, it was subjected to a silicagel column chromatography, to obtain 34mg of the compound presented in the title(60% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.88 (d, 3H, J=6.5Hz), 0.7-1.0 (m, 3H), 1.0-2.5 (m, 25H), 2.9-3.1 (m, 1H), 3.7-3.9 (q, 1H, J=8.9Hz), 4.0-4.2 (m, 1H), 5.29 (brs, 1H), 5.3-5.6 (m, 2H), 6.0-6.1 (m, 1H), 6.6-6.9 (m, 1H). [Reference example 4] Preparation of (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 36mg of (1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene was taken and dissolved in 1.5mL of dimethylformamide. After addition of 32mg of 1,1'-carbonyldiimidazole, it was stirred at 50°C for 1 hour. It was then cooled to ambient temperature, 25mg of imidazole and 33mg of methylamine hydrochloride were added, and stirred at 50°C for 1.5 hours. An aqueous solution saturated with ammonium chloride was added and extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, it was subjected to a silicagel column chromatography, to obtain 22mg of the compound presented in the title (57% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.91 (brt, 3H, J=6.8Hz), 1.16 (s, 3H), 1.2-1.7 (m, 15H), 1.8-2.5 (m, 9H), 2.9-3.1 (m, 1H), 2.94 (s, 3H), 3.00 (s, 3H), 3.7-3.9 (m, 1H), 5.30 (brs, 1H), 5.3-5.5 (m, 1H), 5.5-5.7 (m, 1H). [Reference examples 5-8] The compounds shown in Table 2 were obtained with a method identical to Reference example 4. [Reference example 9] Preparation of (1S,5S,6R,7R)-3-[4-N-(2-ethoxycarbonylethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 36mg of (1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene was taken and dissolved in 1mL of dimethylformamide. After addition of 24mg of 1,1'-carbonyldiimidazole, it was stirred for 20 hours. 14mg of imidazole and 31mg of ethyl 3-aminopropionate were added and stirred for 8 hours. An aqueous solution saturated with ammonium chloride was added and extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, it was subjected to silicagel column chromatography, to obtain 36mg of the compound presented in the title (79% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.91 (brt, 3H, J=6.1Hz), 1.16 (s, 3H), 1.27 (t, 3H, J=7.2Hz), 1.2-1.7 (m, 13H), 2.53 (t, 2H, J=5.9Hz), 1.8-2.6 (m, 11H), 2.9-3.1 (m, 1H), 3.51 (q, 2H, J=5.8Hz), 3.77 (q, 1H, J=7.0Hz), 4.15 (q, 2H, J=7.1Hz), 5.28 (brs, 1H), 5.3-5.5 (m, 1H), 5.5-5.7 (m, 1H), 6.0-6.2 (m, 1H). [Reference example 10] Preparation of (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 3ml of toluene and 1mL of 15% trimethylaluminium-hexane solution were added to a nitrogen exchanged flask. 148µL of piperidine was added and stirred at ambient temperature for 3 hours. 59mg of (1S,5S,6R,7R)-3-(4-methoxycarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene was dissolved and added in 4mL of toluene, and stirred at 60°C for 18 hours. An aqueous solution saturated with potassium hydrogen sulfate was added, extracted with ethyl acetate. The organic layer was washed with an aqueous solution saturated with sodium bicarbonate, and dried with anhydrous sodium sulfate. After filtration and concentration, it was subjected to a silicagel column chromatography, to obtain 62mg of the compound presented in the title (93% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.8-0.95 (m, 3H), 0.90 (d, 3H, J=6.2Hz), 1.1-1.7 (m, 22H), 1.8-2.5 (m, 9H), 2.9-3.1 (m, 1H), 3.3-3.5 (m, 2H), 3.5-3.6 (m, 2H), 3.77 (q, 1H, J=6.8Hz), 4.1-4.25 (m, 1H), 5.29 (brs, 1H), 5.45-5.6 (m, 2H). [Reference examples 11-13] The compounds shown in Table 3 were obtained with a method identical to Reference example 10. [Reference example 14] Preparation of (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-(tetrahydropyran-2-yloxy)-bicyclo[3.3.0]-2-octene 40mg of (1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-(tetrahydropyran-2-yloxy)-bicyclo[3.3.0]-2-octene was dissolved in 4mL of dimethylformamide, and 27mg of 1-hydroxybenzotriazole monohydrate was added. While stirring on ice, 71µL of diisopropylamine was added and stirred at 0°C for 20 minutes. 38mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride was added, and stirred for 13 hours. An aqueous solution of ammonium chloride was added and extracted with ethyl acetate. The organic layer was washed with a saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, it was subjected to a silicagel column chromatography, to obtain 29mg of the compound presented in the title (56% yield). 1H-NMR(270MHz, CDCl 3 ):δ 1.22 (d, 6H, J=5.0Hz), 1.37 (d, 6H, J=5.0Hz), 1.1-1.8 (m, 13H), 2.34 (s, 3H), 1.8-2.7 (m, 11H), 2.9-3.1 (m, 1H), 3.5-4.0 (m, 5H), 4.1-4.3 (m, 1H), 5.15-5.3 (m, 2H), 5.45-5.9 (m, 1H), 6.9-7.05 (m, 3H), 7.1-7.25 (m, 1H). [Reference example 15] Preparation of (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane. 59mg of (1S,2R,3R,5S)-7-[(E)-4-carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane was taken and was dissolved in 2mL of dimethylformamide. 25mg of 1,1'-carbonyldiimidazole was added and, stirred at ambient temperature for 5 hours. 20mg of imidazole and 23mg of dimethylamine hydrochloride were added, and stirred at ambient temperature for 18 hours. An aqueous solution saturated with ammonium chloride was added and extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, it was subjected to a silicagel column chromatography, to obtain 17mg of the compound presented in the title (26% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.96 and 1.00 (d, 3H, J=6.9Hz), 1.1-1.3 (m, 1H), 1.5-2.5 (m, 22H), 2.94 (s, 3H), 3.0 (s, 3H), 3.65-3.8 (m, 1H), 3.9-4.05 and 4.1-4.2 (m, 1H), 5.2-5.3 (m, 1H), 5.45-5.65 (m, 2H). [Reference example 16] Preparation of (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(3-N,N-dimethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran 20mg of (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(3-carboxypropyl)-1H-cyclopenta[b]benzofuran was taken and dissolved in 2mL of dimethylformamide. 16mg of 1,1'-carbonyldiimidazole was added and stirred at 50°C for 1 hour. 13mg of imidazole and 16mg of dimethylamine hydrochloride was added, and stirred at 50°C for 1 hour. An aqueous solution saturated with ammonium chloride was added and extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, it was subjected to a silicagel column chromatography, to obtain 5mg of the compound presented in the title (23% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.9-1.1 (m, 3H), 1.2-1.7 (m, 5H), 1.79 (brs, 3H), 1.9-2.8 (m, 9H), 2.96 (s, 3H), 3.0 (s, 3H), 3.49 (t, 1H, J=8.5Hz), 3.9-4.3 (m, 2H), 5.0-5.2 (m, 1H), 5.5-5.8 (m, 2H), 6.7-6.85 (m, 1H), 6.9-7.05 (m, 2H). [Example 1] Preparation of (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 29mg of (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene obtained in Reference example 3 was taken and dissolved in 4mL of tetrahydrofurane, 20mg of lithium aluminium hydride was added, and stirred for 4 hours. 100µL of an aqueous solution saturated with sodium sulfate was added, then 500mg of anhydrous sodium sulfate was added, and stirred for 18 hours. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to a silicagel column chromatography, to obtain 8mg of the compound presented in the title (29% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.7-1.0 (m, 6H), 1.0-1.6 (m, 16H), 1.8-2.1 (m, 4H), 2.2-2.5 (m, 3H), 2.72 (t, 2H, J=7.0Hz), 2.7-3.1 (m, 5H), 3.76 (q, 1H, J=8.6Hz), 4.0-4.15 (m, 1H), 5.27 (brs, 1H), 5.4-5.6 (m, 2H). [Example 2] The compound shown in Table 4 was obtained with a method identical to Example 1. [Example 3] Preparation of (1S,5S,6R,7R)-3-(5-N-acetylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene 20µL of acetic acid was dissolved in 2mL of dimethylformamide. After adding 60mg of 1,1'-carbonyldiimidazole, it was stirred at 50°C for 1 hour. It was cooled to ambient temperature, and 18mg of (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene was added, and stirred for 18 hours. An aqueous solution saturated with potassium hydrogen sulfate was added and extracted with ethyl acetate. The organic layer was washed with an aqueous solution saturated with sodium bicarbonate, then with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, it was subjected to silicagel column chromatography, to obtain 3.5mg of the compound presented in the title (22% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.7-1.0 (m, 6H), 1.0-1.6 (m, 16H), 1.96 (s, 3H), 1.8-2.1 (m, 4H), 2.2-2.5 (m, 3H), 2.7-3.1 (m, 3H), 3.1-3.4 (m, 2H), 3.76 (q, 1H, J=8.6Hz), 4.0-4.15 (m, 1H), 5.27 (brs, 1H), 5.4-5.6 (m, 2H), 6.6-6.8 (m, 1H). [Example 4] The compound shown in Table 5 was obtained with a method identical to Example 3. [Example 5] Preparation of (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene 36mg of (1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene was taken and was dissolved in 1.5mL of dimethylformamide. After addition of 32mg of 1,1'-carbonyldiimidazole, it was stirred at 50°C for 1 hour. It was then cooled to ambient temperature, 27mg of imidazole was added, and 33mg of dimethylamine hydrochloride was further added. After stirring at 50°C for 1.5 hours, an aqueous solution saturated with ammonium chloride was added and extraction was performed with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, 1.5mL of tetrahydrofurane was added. While stirring on ice, 38mg of lithium aluminium hydride was added and stirring continued at 0°C for 15 minutes, then at 50°C for 1.5 hours. While stirring at ambient temperature, 200µL of an aqueous solution saturated with sodium sulfate was added, then 800mg of anhydrous sodium sulfate and 4mL of ethyl acetate were added, and stirred for 1 hour. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to silicagel column chromatography, to obtain 19mg of the compound presented in the title (51% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.91 (brt, 3H, J=6.9Hz), 1.16 (s, 3H), 1.2-1.6 (m, 15H), 1.8-2.5 (m, 11H), 2.24 (s, 6H), 2.9-3.1 (m, 1H), 3.7-3.9 (m, 1H), 5.27 (brs, 1H), 5.3-5.5 (m, 1H), 5.5-5.7 (m, 1H). [Examples 6-16] The compounds shown in Table 6 were obtained with a method identical to Example 5. [Example 17] Preparation of (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 39mg of (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene obtained in Reference example 6 was taken, 4mL of tetrahydrofuran was added, then 36mg of lithium aluminium hydride was added, and stirred at ambient temperature for 5 hours. While stirring at ambient temperature, 100µL of an aqueous solution saturated with sodium sulfate was added, then 300mg of anhydrous sodium sulfate was added, and stirred for 1.5 hours. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to a silicagel column chromatography, to obtain 26mg of the compound presented in the title (70% yield). 1H-NMR(270MHz, CDCl 3 ):δ 1.2-1.6 (m, 7H), 1.7-2.1 (m, 7H), 2.22 (s, 6H), 2.33 (s, 3H), 2.2-2.5 (m, 4H), 2.7-2.9 (m, 2H), 2.9-3.1 (m, 1H)3.55-3.7 (m, 1H), 4.34 (q, 1H, J=6.5Hz), 5.26 (brs, 1H), 5.45 (dd, 1H, J=15.8, 8.2Hz), 5.59 (dd, 1H, J=15.5, 6.6Hz), 6.9-7.1 (m, 3H), 7.1-7.25 (m, 1H). [Examples 18-26] The compounds shown in Table 7 were obtained with a method identical to Example 17. [Example 27] Preparation of (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 24mg of (1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene was taken and dissolved in 2mL of dimethylformamide. 25mg of 1,1'-carbonyldiimidazole was added and stirred at 50°C for 1.5 hours. It was then cooled to ambient temperature and 100mg pyrrolidine was added. After stirring at 50°C for 2 hours, an aqueous solution saturated with ammonium chloride was added and extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, 3mL of tetrahydrofurane was added. While stirring on ice, 112mg of lithium aluminium hydride was added, and stirring continued at 50°C for 3 hours. While stirring at ambient temperature, 200µL of an aqueous solution saturated with sodium sulfate was added, then 1g of anhydrous sodium sulfate was added, and stirred for 16 hours. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to silicagel column chromatography, to obtain 18mg of the compound presented in the title (65% yield). 1H-NMR(270MHz, CDCl 3 ):δ 1.2-1.6 (m, 7H), 1.7-2.1 (m, 10H), 2.33 (s, 3H), 2.15-2.7 (m, 12H), 2.8-3.1 (m, 1H), 3.5-3.7 (m, 1H), 5.15-5.3 (m, 2H), 5.45-5.65 (m, 1H), 6.9-7.1 (m, 3H), 7.1-7.2 (m, 1H). [Examples 28-33] The compounds shown in Table 8 were obtained with a method identical to Example 27. [Example 34] Preparation of (1S,5S,6R,7R)-3-(5-N,N-diisopropylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 29mg of (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-(tetrahydropyran-2-yloxy)-bicyclo[3.3.0]-2-octene obtained in Reference example 14 was dissolved in 5mL of tetrahydrofuran and 118mg of lithium aluminium hydride was added. After stirring at 50°C for 2 hours, 150µL of an aqueous solution saturated with sodium sulfate was added, then anhydrous sodium sulfate was further added, and stirred for 18 hours. After filtration and concentration, the obtained oily matter was dissolved in 5mL of methanol, and 20mg of p-toluene sulfonic acid monohydrate was added. After stirring for 1.5 hours, an aqueous solution of potassium carbonate was added. After concentration extraction was performed with ethyl acetate, and the organic layer was washed with a saturated saline solution. It was then dried with anhydrous sodium sulfate, filtered, concentrated, and subjected to a silicagel column chromatography, to obtain 3mg of the compound presented in the title (12% yield). 1H-NMR(270MHz, CDCl 3 ):δ 1.03 (d, 12H, J=6.2Hz), 1.2-2.1 (m, 14H), 2.2-2.5 (m, 5H), 2.33 (s, 3H), 2.55-2.75 (m, 2H), 2.8-3.2 (m, 3H), 3.6-3.7 (m, 1H), 5.2-5.3 (m, 2H), 5.4-5.7 (m, 1H), 6.9-7.1 (m, 3H), 7.1-7.25 (m, 1H). [Example 35] Preparation of (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-4-methy]-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane 14mg of (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane obtained in Reference example 15 was taken and 4mL of tetrahydrofuran was added. In addition, while stirring on ice, 15mg of lithium aluminium hydride was added and stirred at ambient temperature for 4 hours. While stirring at ambient temperature, 100µL of an aqueous solution saturated with sodium sulfate was added, 300mg anhydrous sodium sulfate was added, and stirred for 16 hours. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to a silicagel column chromatography, to obtain 9mg of the compound presented in the title (65% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.96 and 1.01 (d, 3H, J=6.8Hz), 1.1-1.6 (m, 7H), 1.79 (t, 3H, J=2.4Hz), 2.24 (s, 6H), 1.7-2.5 (m, 15H), 3.7-3.9 (m, 1H), 3.9-4.2 (m, 1H), 5.2-5.3 (m, 1H), 5.4-5.6 (m, 2H). [Example 36] Preparation of (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane 28mg of (1S,2R,3R,5S)-7-[(E)-4-carboxybutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane was taken and was dissolved in 1.5mL of dimethylformamide. 35mg of 1,1'-carbonyldiimidazole was added and stirred at 50°C for 1 hour. It was then cooled to ambient temperature, 27mg of imidazole was added, and 33m of dimethylamine hydrochloride was also added. After stirring at 50°C for 1.5 hours, an aqueous solution saturated with ammonium chloride was added and extraction was performed with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, 1.5mL of tetrahydrofurane was added. While stirring on ice, 38mg of lithium aluminium hydride was added and stirring continued at 0°C for 15 minutes, then at 50°C for 1.5 hours. While stirring at ambient temperature, 200µL of an aqueous solution saturated with sodium sulfate was added, then 800mg of anhydrous sodium sulfate and 4mL of ethyl acetate were added, and stirred for 1 hour. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to a silicagel column chromatography, to obtain 11mg of the compound presented in the title (41% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.93 (brt, 3H, J=6.8Hz), 1.1-1.6 (m, 12H), 2.24 (s, 6H), 1.7-2.5 (m, 15H), 3.7-3.9 (m, 1H), 3.9-4.2 (m, 1H), 5.2-5.3 (m, 1H), 5.4-5.6 (m, 2H). [Example 37] The compound shown in Table 9 was obtained with a method identical to Example 36. [Example 38] Preparation of (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane 20mg of (1S,2R,3R,5S)-7-[(E)-4-carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane was taken and dissolved in 2mL of dimethylformamide. After addition of 20mg of 1,1'-carbonyldiimidazole, it was stirred at 50°C for 1.5 hours. It was then cooled to ambient temperature, and 100mg of morpholine was added. After stirring at 50°C for 2 hours, an aqueous solution saturated with ammonium chloride was added and extraction was performed with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, 3mL of tetrahydrofurane was added. While stirring, 100mg of lithium aluminium hydride was added, and stirring continued at 50°C for 3 hours. While stirring at ambient temperature, 200µL of an aqueous solution saturated with sodium sulfate was added, then 1g of anhydrous sodium sulfate was added, and stirred for 16 hours. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to a silicagel column chromatography, to obtain 7mg of the compound presented in the title (40% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.96 and 1.01 (d, 3H, J=6.8Hz), 1.1-1.6 (m, 7H), 1.79 (t, 3H, J=2.4Hz), 1.7-2.7 (m, 19H), 3.6-3.9 (m, 5H), 3.9-4.2 (m, 1H), 5.2-5.3 (m, 1H), 5.4-5.6 (m, 2H). [Examples 39-40] The compounds shown in Table 10 were obtained with a method identical to Example 38. [Reference example 17] Preparation of (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran 10mg of (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(3-carboxypropyl)-1H-cyclopenta[b]benzofuran was taken and was dissolved in 2mL of dimethylformamide. After addition of 8.1mg of 1,1'-carbonyldiimidazole, it was stirred at 50°C for 1 hour. It was then cooled to ambient temperature, 6.8mg of imidazole was added, 8.2mg dimethylamine hydrochloride was further added. After stirring at 50°C for 1 hour, an aqueous solution saturated with ammonium chloride was added and extraction was performed with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, 2mL of tetrahydrofurane was added. While stirring on ice, 9.5mg of lithium aluminium hydride was added, and stirring continued at 0°C for 15minutes, and at 50°C for 1 hour. While stirring at ambient temperature, 100µL of an aqueous solution saturated with sodium sulfate was added, 400mg of anhydrous sodium sulfate was added, and stirred for 1 hour. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to a silicagel column chromatography, to obtain 7.5mg of the compound presented in the title (73% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.9-1.1 (m, 3H), 1.2-1.7 (m, 7H), 1.79 (brs, 3H), 1.9-2.7 (m, 9H), 2.24 (s, 6H), 3.49 (t, 1H, J=8.5Hz), 3.9-4.3 (m, 2H), 5.0-5.2 (m, 1H), 5.5-5.8 (m, 2H), 6.7-6.85 (m, 1H), 6.9-7.05 (m, 2H). [Example 41] Preparation of (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(4-morpholinobutyl)-1H-cyclopenta[b]benzofuran 10mg of (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(3-carboxypropyl)-1H-cyclopenta[b]benzofuran was taken and was dissolved in 2mL of dimethylformamide. After addition of 8.1mg of 1,1'-carbonyldiimidazole, it was stirred at 50°C for 1 hour. It was cooled to ambient temperature, and 50mg morpholine was added. After stirring at 50°C for 1 hour, an aqueous solution saturated with ammonium chloride was added and extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and dried with anhydrous sodium sulfate. After filtration and concentration, 2mL of tetrahydrofurane was added. While stirring on ice, 9.5mg of lithium aluminium hydride was added and stirring continued at 0°C for 15 minutes, then at 50°C for 1 hour. While stirring at ambient temperature, 100µL of an aqueous solution saturated with sodium sulfate was added, then 400mg of anhydrous sodium sulfate was added, and stirred for 1 hour. A filtration was performed over celite, and after washing the residue with ethyl acetate, the filtrate was concentrated and subjected to a silicagel column chromatography, to obtain 5.3mg of the compound presented in the title (48% yield). 1H-NMR(270MHz, CDCl 3 ):δ 0.9-1.1 (m, 3H), 1.2-1.7 (m, 7H), 1.78 (brs, 3H), 1.9-2.7 (m, 13H), 3.3-3.6 (m, 1H), 3.6-4.3 (m, 6H), 5.0-5.2 (m, 1H), 5.5-5.8 (m, 2H), 6.7-6.85 (m, 1H), 6.9-7.05 (m, 2H). [Examples 42-43] The compounds shown in Table 11 were obtained with a method identical to Example 41. [Reference example 18] Method for measuring the ability of learning and memory in a rat by the step-through passive avoidance test A step-through passive avoidance instrument made of two chambers separated by a guillotine door was used as the experimental apparatus. One chamber is an illuminated chamber made of transparent acrylic boards (floor: 15cm x 25cm, height: 15cm), the other chamber is a dark chamber made of black acryl boards (same dimensions). In addition, the floor of the dark chamber was equipped with a grid made of 4mm diameter stainless steel pieces separated by 15mm spacing. The grid was connected to an apparatus for delivering electric shocks (shock generator scrambler). First, the guillotine door was opened for one minute to let a rat freely explore the interior of the apparatus. Then, for acquisition trials, the door was closed and the rat was put into the illuminated chamber. 30 seconds later, the door was opened and immediately after the four legs of the rat were put inside the dark chamber, the door was closed and an electric shock was delivered. The strength of the electric shock was 0.5mA for 5 seconds. The training was repeated until the rat remained in the illuminated chamber for more than 120 seconds when the rat was placed in the illuminated chamber immediately after the electric shock and the door was opened in a similar way. 24 hours after the acquisition trials, the rat was put into the illuminating chamber for retention trials, 30 seconds after, the guillotine door was opened, and the time taken for the four legs of the rat to enter the dark chamber was measured (step-through latency). The maximum observation time during retention trials was set to 300 seconds. [Reference example 19] Method for measuring the ability of learning and memory in a rat by the Y-maze test (spontaneous alternation behavior test) A Y-shaped maze made by connecting three arms having a length of 35cm each, a wall height of 25cm and a floor width of 10cm at an angle of 120° with respect to each other. The apparatus was settled on the laboratory floor. A rat was placed at the extremity of one of the arms, was allowed to freely explore the maze for 8 minutes, and a record was taken of the order in which the arms were explored by the rat. By calling (A) the "Total arm entries", and among them, by calling (B) the "Number of spontaneous alternations" which is the number of cases where 3 different arms were selected in sequence, the "Percentage of spontaneous alternations" was calculated with: (B/(A-2))×100. [Reference example 20] Preparation of a model for Alzheimer's disease by the continuous intracerebroventricular administration of β-amyloid proteins 7 week old Wistar male rats (weight 220 to 250g) were used (N=5 to 10). β-amyloid protein (1-42) was dissolved in 35% acetonitrile- 0.1% trifluoroacetic acid in water, injected in a mini-osmotic pump, which had been set to deliver 300pmol/day (volume: 230µL, flow: 0.5µL/hour), and connected to a dental syringe needle through a polyethylene tube. Animals in control group were connected to a pump to which β-amyloid protein (40-1) orvehicleonly was injected. After anesthetizing the rats with pentobarbital (50mg/Kg, i.p.), an incision was performed in each of their scalps, and following the brainatlas, holes were drilled in the cranium. The syringe needle was inserted sothat the tip of the needle was inside the lateral ventricle (A=-0.3mm, L=1.2mm, H=4.5mm), and fixed with dental cement. The osmotic pump was then implanted under the dorsal skin. Taking the day when the mini-osmotic pump was implanted as day 0, on day 5, a Y-maze test was performed following the method indicated in Reference example 2, on day 13 and day 14, a passive avoidance test was performed following the method indicated in Reference example 1, and a decrease in the ability of learning and memory was observed in the group which was administered β-amyloid protein(1-42) in comparison to the group which was administered β-amyloid protein(40-1) or the group which was administered vehicle only. [Reference example 21] Method for evaluating the promotion activity on the neurite outgrowth (1) Mouse neuroblastoma Neuro2A cells (obtained from DAINIPPON PHARMACEUTICAL CO., LTD.) were suspended with a density of 2.5×10 4 cells/mL in DMEM containing 10% FCS and 2mM of Gln, and were plated on commercially available 24-well tissue culture plates with a quantity of 400µL/well. After an overnight culture under the conditions where the temperature was 37°C, and the carbon dioxide content of the air was 5%, the media was exchanged to an identical media containing the test compound, and the culture was further continued for 24 hours. Then microscope photographs were taken with a 20 x lens. Using the photographs, by counting the total number of cells in the field of view and the number of cells with extended neurite, the proportion of cells with extended neurite is calculated. [Reference example 22] Method for evaluating the promotion activity on the neurite outgrowth (2) The cells used and the performed culture method were identical to those in Reference example (1). After being cultured in a media containing the test compound for 24 hours, microscope photographs were taken with a 20 x lens. Transparent sheets were used to cover the latter photographs, in order to copy neural projections with a uniform thickness. The copied sheets were imported into a personal computer as image data, using a scanner. Using image processing software, the area covered by the neurites were calculated, and, since the thickness used to mark the neurite was uniform, the analysis was performed considering that the area was proportional to the length, and allowing to compute the length of neurite per cell. [Reference example 23] Method for measuring the activity of decreasing blood pressure A catheter for monitoring the blood pressure was inserted and placed in the femoral artery, and a catheter for the administration of drug solution was inserted and placed in the femoral vein of male Wistar rats (10-11 weeks old, Charles River) under ether anesthesia. The animals were placed in a Ballman cage, and awakened. After the blood pressure stabilized, a solvent containing ethanol and Tween80 adjusted to the same amount as those in each administered solution was injected by bolus administration. After monitoring blood pressure and heart rate for 60 minutes to verify the absence of effects, the test compound was administered and the blood pressure and the heart rate were further monitored for 60 minutes. The doses of the solvent and the test compound were all 1mL/Kg. The measurements of the blood pressure and the heart rate were performed immediately before administration (0 minutes), at 3, 5, 10, 15, 30 and 60 minutes after administration. For each animal, the blood pressure value measured at each time point was normalized by defining the blood pressure at 0 minute as 100. The test compound was used once it had been dissolved with ethanol and diluted in physiological saline containing Tween80, with, the quantity of test compound, the concentration of ethanol and Tween80 in the administration solution for each group as indicated in Table 12 below. Dose (mg/kg) Concentration of Ethanol (%) Concentration of Tween80 (%) 0.1 1 0.198 1 10 0.18 [Reference example 24] Measurement of the permeability of the compound through the blood brain barrier Bovine cerebral capillary endothelial cells were cultured on a 100mm diameter plate (coated with collagen I) to obtain confluency. The cells were cultured for 15 minutes in an incorporation media (141mM NaCl, 4mM KCl, 2mM CaCl 2 , 1mM H 2 SO 4 , 10mM HEPES, 10mM D-glucose) containing the test compound (1µM), to incorporate the test compound into the cells. Then, the test compound incorporated into the cells was extracted with ethanol extraction, and quantified by HPLC. The rate of incorporation was calculated with the equation below. amount of test compound in the ethanol-extracted fraction/amount of test compound in the incorporation solution × 100(%) [Example 44] Measurement of the ameliorating effect on learning and memory deficit (1) Test compound: (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The ameliorating effect on learning and memory deficit was evaluated with the evaluation methods of Reference examples 18 and 20. The test compound was dissolved in the β-amyloid protein solution, and injected at the same time as the β-amyloid protein, using an osmotic pump. The results are shown in Table 13 below. Time taken to move into the dark chamber during retention trials mean value ± standard error (unit: seconds) β-amyloid protein(40-1) 300pmol/day group 207.3 ± 51.5(n=6) β-amyloid protein(1-42) 300pmol/day group 140.2 ± 53.8(n=5) β-amyloid protein(1-42) 300pmol/day and test compound 12fmol/day group 217.8 ± 44.9(n=6) The time taken to move into the dark chamber was extended for the test compound group when compared to the β-amyloid protein(1-42) only group. In other words, in the present experiment, the test compound displayed an activity to ameliorate the learning and memory deficit. [Example 45] Measurement of the ameliorating effect on learning and memory deficit (2) Test compound: (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The ameliorating effect on learning and memory deficit was evaluated with the evaluation methods of Reference examples 18 and 20. The test compound was dissolved in the β-amyloid protein solution, and injected at the same time as the β-amyloid protein, using an osmotic pump. The results are shown in Table 14 below. Time taken to move into the dark chamber during retention trials mean value ± standard error (unit: seconds) β-amyloid protein(40-1) 300pmol/day group 263.3 ± 36.7(n=3) β-amyloid protein(1-42) 300pmol/day group 132.8 ± 58.1(n=5) β-amyloid protein(1-42) 300pmol/day and test compound 12fmol/day group 212.2 ± 58.5(n=5) The time taken to move into the dark chamber was extended for the test compound group when compared to the β-amyloid protein(1-42) only group. In other words, in the present experiment, the test compound displayed an activity to ameliorate learning and memory deficit. [Example 46] Measurement of the ameliorating effect on learning and memory deficit (3) Test compound: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The ameliorating effect on learning and memory deficit was evaluated with the evaluation methods of Reference examples 18 and 20. The test compound was dissolved in the β-amyloid protein solution, and injected at the same time as the β-amyloid protein, using an osmotic pump. The results are shown in Table 15 below. Time taken to move into the dark chamber during retention trials mean value ± standard error (unit: seconds) β-amyloid protein(40-1) 300pmol/day group 263.3 ± 36.7(n=3) β-amyloid protein(1-42) 300pmol/day group 132.8 ± 58.1(n=5) β-amyloid protein(1-42) 300pmol/day and test compound 12fmol/day group 242.0 ± 36.3(n=4) The time taken to move into the dark chamber was extended for the test compound group when compared to the β-amyloid protein(1-42) only group. In other words, in the present experiment, the test compound displayed an activity to amliorate learning and memory deficit. [Example 47] Measurement of the ameliorating effect on learning and memory deficit (4) Test compound: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The ameliorating effect on learning and memory deficit was evaluated with the evaluation methods of Reference examples 18 and 20. The test compound was dissolved in the β-amyloid protein solution, and injected at the same time as the β-amyloid protein, using an osmotic pump. The results are shown in Table 16 below. Time taken to move into the dark chamber during retention trials mean value ± standard error (unit: seconds) Vehicle only group 286.7 ± 13.3(n=6) β-amyloid protein(1-42) 300pmol/day group 191.7 ± 49.0(n=6) β-amyloid protein(1-42) 300pmol/day and test compound 12fmol/day group 300.0 ± 0.0(n=5) The time taken to move into the dark chamber was extended for the test compound group when compared to the β-amyloid protein(1-42) only group. In other words, in the present experiment, the test compound displayed an activity to ameliorate learning and memory deficit. [Example 48] Measurement of the ameliorating effect on learning and memory deficit (5) Test compound: (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The ameliorating effect on learning and memory deficit was evaluated with the evaluation methods of Reference examples 19 and 20. The test compound was dissolved in the β-amyloid protein solution, and injected at the same time as the β-amyloid protein, using an osmotic pump. The results are shown in Table 17 below. Occurrence of spontaneous alternation behavior mean value ± standard error (unit: %) β-amyloid protein(40-1) 300pmol/day group 72.2 ± 2.9(n=6) β-amyloid protein(1-42) 300pmol/day group 65.6 ± 3.4(n=6) β-amyloid protein(1-42) 300pmol/day and test compound 12fmol/day group 74.1 ± 2.5(n=6) The occurrence of spontaneous alternation behavior increased for the test compound group when compared to the β-amyloid protein(1-42) only group. In other words, in the present experiment, the test compound displayed an activity to ameliorate learning and memory deficit. [Example 49] Measurement of the ameliorating effect on learning and memory deficit (6) Test compound: (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The ameliorating effect on learning and memory deficit was evaluated with the evaluation methods of Reference examples 19 and 20. The test compound was dissolved in the β-amyloid protein solution, and injected at the same time as the β-amyloid protein, using an osmotic pump. The results are shown in Table 18 below. Occurrence of spontaneous alternation behavior mean value ± standard error (unit: %) β-amyloid protein (40-1) 300pmol/day group 76.3 ± 4.9(n=6) β-amyloid protein (1-42) 300pmol/day group 66.5 ± 4.7(n=6) β-amyloid protein (1-42) 300pmol/day and test compound 12fmol/day group 72.1 ± 3.7(n=6) The occurrence of spontaneous alternation behavior increased for the test compound group when compared to the β-amyloid protein(1-42) only group. In other words, in the present experiment, the test compound displayed an activity to ameliorate learning and memory deficit. [Example 50] Measurement of the ameliorating effect on learning and memory deficit (7) Test compound: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The ameliorating effect on learning and memory deficit was evaluated with the evaluation methods of Reference examples 19 and 20. The test compound was dissolved in the β-amyloid protein solution, and injected at the same time as the β-amyloid protein, using an osmotic pump. The results are shown in Table 19 below. Occurrence of spontaneous alternation behavior mean value ± standard error (unit: %) β-amyloid protein (40-1) 300pmol/day group 76.3 ± 4.9(n=6) β-amyloid protein (1-42) 300pmol/day group 66.5 ± 4.7(n=6) β-amyloid protein(1-42) 300pmol/day and test compound 12fmol/day group 73.2 ± 5.1(n=6) The occurrence of spontaneous alternation behavior increased for the test compound group when compared to the β-amyloid protein(1-42) only group. In other words, in the present experiment, the test compound displayed an activity to ameliorate learning and memory deficit. [Example 51] Measurement of the ameliorating effect on learning and memory deficit (8) Test compound: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The ameliorating effect on learning and memory deficit was evaluated with the evaluation methods of Reference examples 19 and 20. The test compound was dissolved in the β-amyloid protein solution, and injected at the same time as the β-amyloid protein, using an osmotic pump. The results are shown in Table 20 below. Occurrence of spontaneous alternation behavior mean value ± standard error (unit: %) Vehicle only group 68.2 ± 2.3(n=6) β-amyloid protein (1-42) 300pmol/day group 59.1 ± 3.0(n=6) β-amyloid protein (1-42) 300pmol/day and test compound 12fmol/day group 71.7±4.0(n=6) The occurrence of spontaneous alternation behavior increased for the test compound group when compared to the β-amyloid protein(1-42) only group. In other words, in the present experiment, the test compound displayed an activity to ameliorate learning and memory deficit. [Example 52] Evaluation of the promotion activity on the neurite outgrowth (1) Test compound: (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The promotion activity on the neurite outgrowth was evaluated with the method of Reference example 21. In addition to the test compound, PGE 1 , whose promotion activity on the neurite outgrowth is known in other neuroblastoma cell strain (Miki et al ., Drugs and treatments, Vol.21, No.1, p93), was administered to an additional group for comparison. The results are shown in Table 21 below. Compound Proportion of cells with neurite (%) mean value ± standard error Test compound not added 8.8 ± 1.3 PGE 1 (10nM) 26.0 ±3.0 Test compound( 10nM) 40.3 ± 3.5 This experiment shows that a promotion activity on the neurite outgrowth was detected for the test compound (level of significance: p<0.01). In addition, test compound showed a strong promotion activity when compared to PGE 1 which is known to have a promotion activity on the neurite outgrowth (level of significance: p<0.05). [Example 53] Evaluation of the promotion activity on the neurite outgrowth (2) Test compound: (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The promotion activity on the neurite outgrowth was evaluated with the method of Reference example 22. In addition to the test compound, as in Example 52, PGE 1 was administered to an additional group for comparison. The results are shown in Table 22 below. Compound Length of neurite per single cell (pixel/cell) mean value ± standard error Test compound not added 6.1 ± 0.9 PGE 1 (1nM) 14.2 ± 1.5 Test compound (1nM) 22.6 ± 3.0 This experiment shows that a promotion activity on the neurite outgrowth was detected for the test compound.(level of significance: p<0.01). In addition, test compound showed a strong promotion activity when compared to PGE 1 which is known to have a promotion activity on the neurite outgrowth (level of significance: p<0.05). [Example 54] Evaluation of the promotion activity on the neurite outgrowth (3) Test compound: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The promotion activity on the neurite outgrowth was evaluated with the method of Reference example 21. In addition to the test compound, as in Example 52, PGE 1 was administered to an additional group for comparison. The results are shown in Table 23 below. Compound Proportion of cells with neurite (%) mean value ± standard error Test compound not added 6.1 ± 0.9 PGE 1 (10nM) 19.5 ± 1.9 Test compound (10nM) 38.7 ± 6.6 This experiment shows that a promotion activity on the neurite outgrowth was detected for the test compound.(level of significance: p<0.01). In addition, test compound showed a strong promotion activity when compared to PGE 1 which is known to have a promotion activity on the neurite outgrowth (level of significance: p<0.05). [Example 55] Evaluation of the promotion activity on the neurite outgrowth (4) Test compound: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The promotion activity on the neurite outgrowth was evaluated with the method of Reference example 22. In addition to the test compound, as in Example 52, PGE 1 was administered to an additional group for comparison. The results are shown in Table 24 below. Compound Length of neurite per single cell (pixel/cell) mean value ± standard error Test compound not added 1.2 ± 0.13 PGE 1 (100nM) 5.7 ± 1.03 Test compound (100nM) 8.0 ± 1.37 This experiment shows that a promotion activity on the neurite outgrowth was detected for the test compound.(level of significance: p<0.01). [Example 56] Evaluation of the promotion activity on the neurite outgrowth (5) Test compound A: (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran Test compound B: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene Test compound C: (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane Test compound D: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene Test compound E: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The promotion activity on the neurite outgrowth was evaluated with the method of Reference example 21. In parallel to the test compounds, as in Example 52, PGE 1 was administered to an additional group for comparison. The results are shown in Table 25 below. Compound Concentration of test compound (µM) Promotion activity on the neurite outgrowth (value relative to PGE 1 ) Vehicle - 0.79 PGE 1 10 1.00 Test compound A 10 1.17 Test compound B 10 1.63 Test compound C 10 1.15 Test compound D 10 1.31 Test compound E 10 1.58 [Example 57] Evaluation of the promotion activity on the neurneurite outgrowth (6) Test compound A: (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene Test compound B: (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene Test compound C: (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene The promotion activity on the neurneurite outgrowth was evaluated using the method of Reference example 21. In parallel to the test compounds, as in Example 52, PGE 1 was administered to an additional group for comparison. The results are shown in Table 26 below. Compound Concentration of compound (µM) Promotion activity on the neurite outgrowth (value relative to PGE1) Vehicle - 0.45 PGE 1 10 1.00 Test compound A 10 1.15 Test compound B 0.1 1.12 Test compound C 10 1.25 [Example 58] Evaluation of the promotion activity on the neurneurite outgrowth (7) Test compound A: (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene Test compound B: (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene The promotion activity on the neurneurite outgrowth was evaluated with the method of Reference example 21. In parallel to the test compounds, as in Example 52, PGE 1 was administered to an additional group for comparison. The results are shown in Table 27 below. Compound Concentration of compound (µM) Promotion activity on the neurite outgrowth (value relative to PGE1) Vehicle - 0.53 PGE 1 10 1.00 Test compound A 10 1.39 Test compound B 10 1.50 [Example 59] Measurement of the blood pressure decreasing activity (1) Test compound: (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The effect on the blood pressure was evaluated with the method of Reference example 23. The variation in the blood pressure after administration of the test compound was as indicated in Table 28 below. Dose Blood pressure (values normalized to 100 at 0 minute) (± standard error) mg/kg 0min 3min 5min 10min 15min 30min 60min Solvent only 0 100 98.4 97.5 102.6 100.6 102.2 98.8 (2.0) (0.9) (2.3) (1.1) (4.8) (3.6) Test compound 0.1 100 102.2 101.1 100.0 101.5 97.3 101.1 (1.0) (0.4) (1.9) (1.9) (1.9) (2.8) Solvent only 0 100 101.8 99.2 98.5 100.0 99.8 97.0 (1.1) (0.5) (1.5) (1.2) (1.7) (1.2) Test compound 1 100 93.7 95.7 101.0 100.9 101.1 104.8 (5.6) (5.7) (4.8) (3.2) (2.0) (3.2) In the 1mg/Kg group, the test compound exerted a decrease in blood pressure immediately after administration. However, it was observed that recovery was fast, only a slight decrease existed after 3 minutes, and after 10 minutes, the blood pressure returned to normal values. No significant variations were observed in the 0.1mg/Kg group. In other words, it is clear that the test compound is a compound having an extremely small activity on the circulatory system. [Example 60] Measurement of the blood pressure decreasing activity (2) Test compound: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene The effect on the blood pressure was evaluated with the method of Reference example 23. The variation in the blood pressure after administration of the test compound was as indicated in Table 28 below. Dose Blood pressure (values normalized to 100 at 0 minute) (± standard error) mg/kg 0min 3min 5min 10min 15min 30min 60min Solvent only 0 100 101.1 99.7 103.7 105,2 101.4 98.3 (0.8) (1.8) (3.0) (3.2) (3.0) (2.7) Test compound 0.1 100 100.8 99.7 102.1 101.7 101.2 101.5 (2.2) (2.9) (1.7) (2.8) (1.3) (3.7) Solvent only 0 100 101.7 98.5 97.8 98.7 98.2 94.0 (1.0) (1.1) (1.0) (1.5) (2.8) (3.5) Test compound 1 100 108.1 105.1 105.9 105.9 105.0 99.9 (1.6) (1.1) (0.8) (1.8) (1.8) (2.5) In other words, it is clear that, since no significant variations were observed in the 0.1mg/Kg dose and the 1mg/Kg dose, the test compound is a compound having an extremely small activity on the circulatory system. [Example 61] Measurement of the permeability through the blood brain barrier (1) Test compound A: (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene Test compound B: (1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene Permeability through the blood brain barrier was measured with the method of Reference example 24. As a reference, measurements were also performed for the well-known isocarbacyclin derivative (test compound B), and compared. The results are shown in Table 30 below. Compound Rate of incorporation into bovine capillary endothelial cells (mean value of two experiments) Test compound A 5.09% Test compound B below detection limit It is clear from this experiment that the test compound has a high permeability through the blood brain barrier. [Example 62] Measurement of the permeability through the blood brain barrier (2) Test compound A: (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene Test compound B: (1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene Permeability through the blood brain barrier was measured with the method of Reference example 24. As a reference, measurements were also performed for the well-known isocarbacyclin derivative (test compound B), and compared. The results are shown in Table 31 below. Compound Rate of incorporation into bovine capillary endothelial cells (mean value of two experiments) Test compound A 15.8% Test compound B below detection limit In other words, it is clear that the test compound A has a high permeability through the blood brain barrier. Usability in the industry The nitrogen-containing compound of the present invention represented by the above equation (1) has an activity for the remedy of nerve damage. Therefore, the compound of the present invention can be used as a therapeutic agent for diorders due to nerve damage or nerve lesions due to external injuries.

Claims: Use of an agent wherein the active ingredient is a nitrogen-containing compound described in Formula (1) shown below: In Formula (1), the symbol represents a single bond or a double bond; G represents one functional group chosen from the group consisting of the Formulae (G1) and (G3) shown below: In Formula (G1) and Formula (G3) the symbol represents the site of linkage with A 1 ; R 4 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group or a group selected from methoxymethyl, 1-ethoxyethyl, 1-methoxy-1-methylethyl, 2-ethoxy-1-methylethyl, 2-methoxyethoxymethyl, tetrahydropyrane-2-yl and 6,6-dimethyl-3-oxa-2-oxo-bicyclo[3.1.0]hexane-4-yl; W represents a single bond, -CH 2 -, -(CH 2 ) 2 -, -(CH 2 ) 3 -, -CH=CH-, -CH=CHCH 2 -, -C=C- or -C≡CCH 2 -; m may be either 0 or 1, with the proviso that when W is a single bond, m is equal to 1; R 5 and R 6 are either identical or different and, either represents one functional group chosen from the following items 1) to 5): 1) a hydrogen atom; 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, an acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents); 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); or, when R 5 and R 6 are bonded to each other, they represent a substituted or an unsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); R 7 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having 2 to 5 carbon atoms,a sulfonyl group having 1 to 8 carbon atoms, a functional group forming the acetal bond together with the oxygen atom bound to R 7 , or, when R 7 and R 5 are bonded to each other, it represents one portion of the bond forming the carbonyl group together with the carbon atom bonded to R 5 and the oxygen atom bonded to R 7 . A 2 represents a single bond, a Formula (A2A) shown below, a Formula (A2B) shown below or a Formula (A2C) shown below: ―O― In the formula, R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms; In the formula, n represents 0, 1, or 2; A 1 represents the items 1) or 2) below: 1) a single bond; 2) a functional group which bridges G and A 2 through an identical atom or through different atoms, and chosen from: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group; A 3 represents the items 1) or 2) below: 1) a single bond; 2) a functional group which bridges A 2 and A 4 through an identical atom or through different atoms, and chosen from: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group; A 4 represents either of the items 1) to 4) below: 1) a single bond; 2) a carbonyl group; 3) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which bridges the nitrogen atom, bonded to R 1 and R 2 , and A 3 through an identical atom or through different atoms; 4) when A 4 and R 1 are bonded to each other, a functional group forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to (when A 4 or R 1 and the nitrogen atom they are bonded to are bonded through a double bond, R 2 represents the bond between A 4 or R 1 and the nitrogen atom); with the proviso that in the combination of A 1 , A 2 , A 3 and A 4 , A 1 , A 2 , A 3 and A 4 may not simultaneously represent bonds; and when A 2 represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A 2 and the nitrogen atom bonded to R 1 and R 2 must be bonded with more than two carbon atoms in between; R 1 and R 2 are either identical or different, and either represent one functional group chosen from the following items 1) to 7): 1) a hydrogen atom; 2) a substituted or an unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and, heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as substituents); 3) a substituted or an unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 4) a substituted or an unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 5) a substituted or an unsubstituted heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 6) an acyl group having 1 to 10 carbon atoms when A 4 is not a carbonyl group, 7) a sulfonyl group having 1 to 8 carbon atoms when A 4 is not a carbonyl group (with the proviso that when either R 1 or R 2 represents a sulfonyl group having 1 to 8 carbon atoms, the other may neither be an acyl group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8 carbon atoms), or, when R 1 and R 2 are bonded together, they represent a functional group forming a cyclic amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents; in the manufacture of a medicament for the treatment of neural damage. Use according to claim 1, wherein G in the above Formula (1) is one functional group chosen from the group consisting of the Formulae (G1E) and (G3E) shown below: In the above Formula (G1E) and (G3E), the symbol , R 4 , R 5 , R 6 , R 7 , m, and W have the same definition as in the above Formula (1); the symbol indicates that the bond is in the β position with respect to the carbon atom forming the cyclic structure it is bonded to; the symbol ----- indicates that the bonds are in the α position with respect to the carbon atoms forming the cyclic structure they are bonded to. Use according to claim 1, wherein G in the above Formula (1) is a functional group having the Formula (G1E). Use according to claim 1, wherein G in the above Formula (1) is a functional group having the Formula (G3E). Use according to any of Claims 1 to 4, wherein A 4 in the above Formula (1) is a carbonyl group. Use according to any of Claims 1 to 4, wherein A 4 in the above Formula (1) is a methylene group. Use according to any preceding claim, wherein the neural damage is selected from the group consisting of: 1) Neuro-degenerative disorders such as Alzheimer's disease, Pick's disease, Lewy body disease, Parkinson's disease, Huntington's chorea, spinocerebellar degeneration and amyotrophic lateral sclerosis; 2) demyelinating disorders such as acute disseminated encephalomyelitis and multiple sclerosis; 3) metabolic disorders such as brain lipidosis and Wilson's Disease; 4) infectious disorders such as meningitis and Creutzfeld-Jacob disease; 5) peripheral neural disorders such as polyneuritis and Guillain-Barre Syndrome; 6) cerebrovascular disorder such as cerebral infarction and transient ischemia; 7) nervous disorders (neuropathies) associated with diabetes and renal diseases; and 8) brain tumors. A nitrogen-containing compound represented by Formula (2) shown below or a salt thereof: In Formula (2), the symbol represents a single bond or a double bond; G represents one functional group chosen from the group consisting of the Formulae (G1) and (G3), shown below: In Formula (G1) and Formula (G3), the symbol represents the site of linkage with A 10 ; R 4 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group or a group selected from methoxymethyl, 1-ethoxyethyl, 1-methoxy-1-methylethyl, 2-ethoxy-1-methylethyl, 2-methoxyethoxymethyl, tetrahydropyrane-2-yl and 6,6-dimethyl-3-oxa-2-oxo-bicyclo[3.1.0]hexane-4-yl; W represents a single bond, -CH 2 -, -(CH 2 ) 2 -, -(CH 2 ) 3 -, -CH=CH-, -CH=CHCH 2 -, -C≡C- or -C≡CCH 2 -; m may be either 0 or 1, with the proviso that when W is a single bond, m is equal to 1; R 5 and R 6 are either identical or different and, either represent one functional group chosen from the following items 1) to 5): 1) a hydrogen atom; 2) a substituted or an unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents, substituted or unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having 1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), substituted or unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents), and, substituted or unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents) may be cited as substituents); 3) a substituted or an unsubstituted alicyclic hydrocarbon group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 4) a substituted or an unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 5) a substituted or an unsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); or, when R 5 and R 6 are bonded to each other, they represent a substituted or an unsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); R 7 represents a hydrogen atom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having 2 to 5 carbon atoms,a sulfonyl group having 1 to 8 carbon atoms, a functional group forming the acetal bond together with the oxygen atom bound to R 7 , or, when R 7 and R 5 are bonded to each other, it represents one portion of the bond forming the carbonyl group together with the carbon atom bonded to R 5 and the oxygen atom bonded to R 7 . A 20 represents a single bond, a Formula (A2A) shown below, a Formula (A2B) shown below or a Formula (A2C) shown below: ―O― In the formula, R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms; In the formula, n represents 0, 1, or 2; A 10 represents the items 1) or 2) below: 1) a single bond; 2) a functional group which bridges G and A 20 through an identical atom or through different atoms, and chosen from: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group; A 30 represents the items 1) or 2) below: 1) a single bond; 2) a functional group which bridges A 20 and A 40 through an identical atom or through different atoms, and chosen from: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a phenylene group; A 40 represents any of the items 1) to 3) below: 1) a single bond; 2) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which bridges the nitrogen atom, bonded to R 10 and R 20 , and A 30 through an identical atom or through different atoms; 3) when A 40 and R 10 are bonded to each other, a functional group forming a 5 to 8 membered ring together with the nitrogen atom they are bonded to (when A 40 or R 10 and the nitrogen atom they are bonded to are bonded through a double bond, R 20 represents the bond between A 40 or R 10 and the nitrogen atom); with the proviso that in the combination of G, A 10 , A 20 , A 30 , and A 40 , when G represents the Formula (G1) and either of A 10 or A 30 is a phenylene group, A 20 may not be a single bond; and when A 20 represents a single bond, then G and the nitrogen atom bonded to R 10 and R 20 must be bonded with more than two carbon atoms in between; and when A 20 represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A 20 and the nitrogen atom bonded to R 10 and R 20 must be bonded with more than two carbon atoms in between; R 10 and R 20 are either identical or different, and either represent one functional group chosen from the following items 1) to 7): 1) a hydrogen atom (with the proviso that when R 10 and R 20 both represent a hydrogen atom, only in the case where G is equal to Formula (G1)), 2) a substituted or an unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and, heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as substituents); 3) a substituted or an unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, an acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 4) a substituted or an unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 5) a substituted or an unsubstituted heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents); 6) an acyl group having 1 to 10 carbon atoms; 7) a sulfonyl group having 1 to 8 carbon atoms (with the proviso that when either R 10 or R 20 represents a sulfonyl group having 1 to 8 carbon atoms, the other may neither be an acyl group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8 carbon atoms); or, when R 10 and R 20 are bonded together, they represent a functional group forming a cyclic amino group having 4 to 8 carbon atoms together with the nitrogen atom they are bonded to (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited as substituents. A nitrogen-containing compound or a salt thereof of Claim 8, wherein G in the above Formula (2) is one functional group chosen from the group consisting of the Formulae (G1E) and (G3E), shown below: In the above Formula (G1E) and (G3E), the symbol , R 4 , R 5 , R 6 , R 7 , m, and W have the same definition as in the above Formula (1); the symbol indicates that the bond is in the β position with respect to the carbon atom forming the cyclic structure it is bonded to; the symbol ― indicates that the bonds are in the a position with respect to the carbon atoms forming the cyclic structure they are bonded to. A nitrogen-containing compound or a salt thereof of Claim 8, wherein G in the above Formula (2) is a functional group having the Formula (G1). A nitrogen-containing compound or a salt thereof of Claim 8, wherein G in the above Formula (2) is a functional group having the Formula (G1E). A nitrogen-containing compound or a salt thereof of Claim 8, wherein G in the above Formula (2) is a functional group having the Formula (G3E). A pharmaceutical composition formed by a nitrogen-containing compound indicated by Formula (2) according to any of claims 8 to 12, and a pharmaceutically accepted carrier.

Inventors: ARAI TAKAMI, SAKURAI KATSUTOSHI, SUGIURA SATOSHI, SUWA YORIMASA, SUZUKI JUN, TANOKURA AKIRA, TSUTSUMI TAKAHARU, YOSHIOKA NOBORU, ARAI, TAKAMI, SAKURAI, KATSUTOSHI, SUGIURA, SATOSHI, SUWA, YORIMASA, SUZUKI, JUN, TANOKURA, AKIRA, TSUTSUMI, TAKAHARU, YOSHIOKA, NOBORU, Arai, Takami Teijin Limited, Sakurai, Katsutoshi Teijin Limited, Sugiura, Satoshi Teijin Limited, Suwa, Yorimasa Teijin Limited, Suzuki, Jun Teijin Limited, Tanokura, Akira Teijin Limited, Tsutsumi, Takaharu Teijin Limited, Yoshioka, Noboru Teijin Limited
Applicants: TEIJIN LTD, TEIJIN LIMITED
Application year: 2000
Main classification: A61K31
IPC codes: C07D295, C07D213, C07C215, A61P25, C07C235, C07C233, A61K31, C07D309, C07D307, A61P9, C07D405