PROCESS FOR THE SYNTHESIS OF POLYCARBAMATES

Abstract: Process for the synthesis of polyurethane derivatives from aromatic polyamine compounds. The method involves reaction of an aromatic polyamine compound with CO and O2 in the presence of a catalyst comprising a Group VIII or lanthanide metal on a solid support and a halogenide promoter.

Description: PROCESS FOR THE SYNTHESIS OF POLYCARBAMATES Field of Invention This invention relates to a method for the preparation of polymeπc carbamates by oxidative carbonylation of polymeπc amino compounds. More particularly, it relates to an industrially advantageous method of producing polymeπc MDU (methylene diphenyl diurethane) in high selectivity by a direct carbonylation method. This route provides a non- phosgene method for the preparation of polymeπc carbamates. Background of the Invention Conventionally, aromatic diisocyanates are prepared by phosgenation of the corresponding diamino compounds. The use of phosgene results in the generation of hydrochloπc acid as a side product, which is the cause of severe corrosion. Considering the environmental hazard and corrosion problems in the phosgenation route, it is important to develop a route without using phosgene. MDI is an important starting mateπal for the production of polyurethanes which are useful as elastomers, artificial leather, coatings, spandex fibers etc. Diphenyl methane dicarbamates are useful precursors for the preparation of diphenylmethane diisocyanates (MDI). Vaπous methods for the preparation of alkyl and aromatic carbamates by carbonylation of corresponding ammo compounds with carbon monoxide and oxygen using Group VIII metal catalysts have been reported (US-A 5,502,241; 5,194,660; 4,694,097 and 4,242,520; EP-A 83096). Asahi Chemicals have proposed a process for the preparation of 4,4 -MDU (US-A 4,552,974, 4,230,877; 4,319,018; GB-A 2054584; JP-A 12357/81) by condensation of ethyl N-phenyl carbamate with formaldehyde in the presence of acids, such as mineral acids or organic sulfonic acids. This requires relatively severe reaction conditions. Recently, Valli and Alper have published a work on oxidative carbonylation of vaπous aliphatic diammes to aliphatic diurethanes using Pd-clay/Nal catalyst system (Organomett. 14, 81 (1995)). Oxidative carbonylation of aniline to the corresponding aromatic urethane has already been disclosed in Catalysis Letters (1994), 25, p 361-364. However, none of the pπor art documents report catalytic conversion of polymeπc amino compounds to their corresponding carbamate deπvatives by a clean and environmentally benign route. The present invention is concerned with the use of a catalytic route for the conversion of aromatic polyamino compounds to polycarbamates via oxidative carbonylation Such a route would eliminate the use of toxic phosgene and associated corrosion problems leading to an environmentally benign process. Summary of the Invention The present invention relates to a clean catalytic process for producing polymeπc carbamate deπvatives in a single step, wherein an aromatic polyamine reacts with carbon monoxide, oxygen and hydroxyl containing organic compounds in the presence of a transition metal catalyst and a halogenide an iodide promoter Usually, the reaction is earned out in a liquid phase at 60 to 300°C and pressures of 10 bar to 100 bar The catalyst compositions descπbed herein compπse a Group VIII metal (e.g. palladium, platinum, nickel, rhodium, ruthenium or cobalt) or a complex thereof, or a lanthanide metal, particularly ceπum. They are used in combination with a halogenide, e.g. an iodide, source as promoter, as illustrated by vaπous alkali metal iodides. Any aromatic polyamine may be employed in the present invention, specifically polymeπc DADPM (DiAmino DiPhenyl Methane). Other essential reagents in the method of this invention are an oxidising agent, such as oxygen, and carbon monoxide, which react with the polymeπc amine and hydroxy compound to form the desired polymeπc carbamate. The end product formed in the present invention is the compound represented by formula I • ROOCHN I Ό- HCOOR (i) Wherein n is greater than 0, suitably 1-20, preferably 1-10; R is an alkyl group having 1-15 carbon atoms, preferably 1-6 carbon atoms, aromatic groups or an alicyc c group having 3-30 carbon atoms, preferably 5-10 carbon atoms. Preferred examples of R groups are methyl, ethyl, propyl (n- or iso-), butyl (n- or iso-), pentyl (n- and vaπous isomers), hexyl (n- and vaπous isomers), alicychc groups such as cyclopentyl and cyclohexyl and aromatic groups such as phenyl, or halogenated phenyl. Representative examples of the compound in the formula I includes polymeπc dimethyl diphenylmethane dicarbamates, diethyl diphenylmethane dicarbamates, dipropyl diphenylmethane dicarbamates. Suitable hydroxyl compounds include aliphatic or aromatic, cyclic or alicychc alcohols such as, for example, methanol, ethanol, n-propanol, isopropanol, pentanol, hexanol, 3,3-dιmethyl-2-butanol, 2-propanol, N,N-dιmethyl- ethanolamme, l-methoxy-2- propanol, 2-methoxyethanol, 1-ethoxycyclo-propanol, 2-ιsopropoxyethanol, 1,3- dιmethoxy-2-propanol, 1,1-dιmethoxy- ethanol, 2-methoxy-l-propanol, 2-methoxy-3- propanol, dimethyloxime, l,3-dιmethoxy-2-propanol , benzyl alcohol, phenol, hydroxylamines, halogenated alcohols such as hexafluoroisopropanol or tπfluoroethanol, halogenated phenols such as ortho-chlorophenol, para-chlorophenol, ortho-fluorophenol, para-fluorophenol and the like An essential constituent of the catalyst composition employed according to the invention is one of the Group VIII-B metals, preferably palladium, or a compound thereof. Thus, palladium black or elemental palladium deposited on zeolite, carbon and oxide supports such as alumina, silica are suitable, as well as palladium compounds such as ha des, and complexes with such compounds as carbon monoxide, amines, phosphines and olefins. The catalytic material also contains a halogenide source, preferably an iodide source. It may be an alkali metal iodide or alkyl iodide. Carbon monoxide employed in the process of the present invention may be pure gaseous carbon monoxide, but may also contain impurities such as nitrogen and carbon dioxide. An impurity content of less than 10% v/v does not affect the reaction pattern and from industrial viewpoint, it may be advantageous to use carbon monoxide with small amounts of impurities. Carbon monoxide is employed in an amount of at least 1 mole per amino group of the polymeric amine compound. A more preferred amount of carbon monoxide is from 2 to 100 moles per amino group of the polymeric amine compound. The oxidising agent used in the process of the invention may be pure oxygen, a gas containing oxygen such as air or an organic nitro compound or a mixture thereof. Oxygen however is preferred. The process also tolerates the employment in some cases of an oxygen containing gas, which additionally contains other non-interfering gases, such as argon, nitrogen or carbon dioxide. The organic hydroxyl compound, which forms one of the reactants, can also function as a solvent. However, where necessary, other solvents, which do not affect the reaction adversely (i.e. inert solvents), may also be used. Exemplary of such solvents are aromatic hydrocarbons such as benzene, toluene, xylene, monochlorobenzene, ortho- dichlorobenzene, and nitriles such as acetonitrile and benzonitrile, ethers such as tetrahydrofuran and 2-dioxan, ketones such as acetone and methyl ethyl ketone, amides such as N,N' dimethyl formamide and N,N' dimethyl acetamide and esters such as ethyl acetate and ethyl benzoate. The component of the catalyst which acts as a precursor can comprise a soluble compound of a transition metal (Group VIII-B) supported an a suitable carrier. Of the transition metals, palladium is especially preferred. Specific examples of the catalyst precursors include Palladium black, supported palladium catalysts such as Pd/C, Pd/Al 2 θ 3 , Pd/ZSM5, Pd/CaC0 3 and the like. Pd black, which has been prepared by various reducing agents, such as hydrazine hydrate, sodium formate, formaldehyde, sodium borohydride, LiAlH t , and H 2 , can be used. Soluble Pd compounds that can be used are : PdCl 2 , PdBr 2 , Pd(N0 3 ) 2 , Pd(OAc) 2 , Pd oxalate, [Pd(NH 3 ) 4 ]X 2 , PdL 2 X, Pd(CO)X, wherein X is Cl, Br or I, and L is triphenyl phosphine, pyridine, isoquinoline, tributyl phosphine, benzonitrile and the like. The halogen-containing promoter can be selected from alkali metal hahdes, alkaline earth metal hahdes, quaternary ammonium hahdes, oxo acids of halogen atom and their salts, and complexes containing halogen ions, organic hahdes and halogen molecules. However, of all the halogen compounds, which act as promoters, those compounds containing iodine are particularly preferred. These include KI, Nal, Lil, Csl, tetrabutyl ammonium iodide, iodine and the like. The oxidative carbonylation reaction of the present invention can be earned out in a temperature range of 80-350°C, more preferably between 120-250°C. However, it has been found that temperature is an important factor in obtaining a good yield of carbamate deπvatives. The carbonylation is earned out under a CO partial pressure of about 5-6000 psig, more preferably between 100-1500 psig The partial pressure of O 2 is employed between 5-1000 psig, more preferably between 10-300 psig. The ratio of CO to 0 2 used in this process is an important factor and activity and selectivity of the catalyst was found to be drastically affected if the CO to O 2 ratio was vaπed. The ratio of CO to 02 in the reactor can be in the range of 1 : 1 to 50: 1, preferably in the range of 5: 1 to 20: 1. In giving effect to the reaction of the present invention, it has been found convenient to employ 1 mole of catalyst per 5-8000 moles of am e functionality More preferred range compπses 1 mole of catalyst per 100-500 moles of amine functionality. The ratio of iodide promoter to metal is in the range of about 0.1 to 50, and more preferably between 0.5 to 15 The amount of organic hydroxyl compound employed is at least 1 mole per amine group of polymeπc amme compound. However, it is more preferable to use 3-100 moles of the hydroxyl group per amino group of polymeπc amine compound. The invention will now be descnbed in detail in the following examples, which should not however be considered to limit the scope of the inventive process. The invention is illustrated by the following examples Example I Polymenc methylene diphenyl urethane was prepared by charging the following components into a 50 ml high-pressure stirred autoclave. polymeπc DADPM 0.8 g Pd-ZSM-5(10%) 0.08 g Sodium iodide (Nal) 0.008 g and excess of ethyl alcohol. 20 ml The autoclave was sealed, flushed twice with carbon monoxide, pressuπsed with 744 psig of carbon monoxide and 56 psig of oxygen resulting in a total pressure of 800 psig at room temperature. The reaction was earned out at 190°C (1000 psig) for two hours with constant vigorous stirπng. The progress of the reaction was monitored by recording the pressure drop, and the gases were repressunsed in a 2: 1 ratio of carbon monoxide to oxygen as necessary. After 2 hr., the reactor was cooled and discharged. The liquid portion was filtered from the insoluble matenal The solvent ethyl alcohol was evaporated completely under vacuum A sticky solid product, weighing about 1.09 g was thus obtained. The product was analysed by IR, Η and 13 C NMR and proved to be more than 95% pure which results in an estimated yield of 75-80%. Example 2 The procedure of example 1 was repeated except that the reactor used was 300 ml instead of 50 ml. The following components were charged to the reactor . polymeπc DADPM 6.4 g Pd-ZSM-5(10%) 0.64 g Sodium iodide (Nal) 0.064 g and excess of ethyl alcohol. The yield obtained of the sticky solid product was about 10.6 g. Estimated yield of carbamate based on weight and 13 C NMR analysis is 75-80%. About 20% of unreacted aromatic amine functions were observed. Example 3 The procedure of example 1 was repeated except that the catalyst 1% Pd-ZSM-% was employed instead of 10% Pd-ZSM-%. The components charged were : polymeric DADPM 0.8 g Pd-ZSM-5(1%) 0.08 g Sodium iodide (Nal) 0.008 g and excess of ethyl alcohol. An insoluble residue of about 0.44g was obtained together with a soluble fraction which based on !3 C NMR proved to be pure carbamate. Example 4 The procedure of example 1 was repeated except that the catalyst Pd metal was employed instead of 10%Pd-ZSM-5. The components charged were : polymeric DADPM 0.8 g Pd-metal 0.004 g Sodium iodide (Nal) 0.008 g and excess of ethyl alcohol. An insoluble residue of about 0.44g was obtained together with a soluble fraction which based on 13 C NMR proved to contain carbamate. Example 5 The procedure of example 1 was repeated except that the catalyst Pd acetate was employed instead of 10%Pd-ZSM-5. The components charged were : polymeric DADPM 0.8 g Pd(OAc) 2 0.008 g Sodium iodide (Nal) 0.008 g and excess of ethyl alcohol. An insoluble residue of about 0.02g was obtained together with a soluble fraction which based on 13 C NMR proved to contain carbamate. Comparative example 1 The procedure of example 1 was repeated except that 4,4' DADPM was used instead of polymeric DADPM as the starting compound. An insoluble residue of 0.12 g was obtained together with a soluble fraction containing 61 % 4,4' diethyl carbamate and 2.4 % 4- amino-4'-ethylcarbonylamino-diphenyl methane (monocarbamate), both measured by HPLC. Comparative example 2 The procedure of example 2 was repeated except that the amount of start material used was halved and that 4,4' DADPM was used instead of polymeric DADPM as the starting compound. An insoluble residue of 1.12 g was obtained together with a soluble fraction containing 49.4 % 4,4' diethyl carbamate and 2.4 % 4-amino-4'-ethylcarbonylamino- diphenyl methane (monocarbamate), both measured by HPLC. Comparative example 3 The procedure of example 3 was repeated except that 4,4' DADPM was used instead of polymeric DADPM as the starting compound. An insoluble residue of 0.106 g was obtained together with a soluble fraction containing 49.5 % 4,4' diethyl carbamate and 7.92 % 4-amino-4'-ethylcarbonylamino-diphenyl methane (monocarbamate), both measured by HPLC. Comparative example 4 The procedure of example 4 was repeated except that 4,4' DADPM was used instead of polymeric DADPM as the starting compound and that the reaction temperature was 170°C. An insoluble residue of 0.32 g was obtained together with a soluble fraction containing 24.1 % 4,4' diethyl carbamate and 6.4 % 4-amino-4'-ethylcarbonylamino-diphenyl methane (monocarbamate), both measured by HPLC. Comparative example 5 The procedure of example 5 was repeated except that 4,4' DADPM was used instead of polymeric DADPM as the starting compound. An insoluble residue of 0.05 g was obtained together with a soluble fraction containing 52.3 % 4,4'diethyl carbamate and 2.7 % 4- amino-4'-ethylcarbonylamino-diphenyl methane (monocarbamate), both measured by HPLC.

Claims: Claims A method for preparing a polymeric carbamate compound which comprises reacting a polymeric amine with carbon monoxide, an oxidising agent and an organic hydroxyl compound in the presence of a catalyst system comprising of a) a precursor containing a Group VIII or lanthanide metal and b) at least one halogen containing promoter effective to promote the said reaction. A method according to claim 1 wherein the polymeric amine compound is polymeric diphenylmethane diamine. A method according to claim 1 or 2 wherein the metal is palladium or cerium. A method according to any one of claims 1-3 wherein the precursor is selected from the group consisting of Pd black, Pd/C, Pd/Al O 3 , Pd/CaCO 3 , Pd/ZSM5, PdCl 2 , PdBr 2 , Pdl 2 , Pd(NO 3 ) 2 , Pd(OAc) 2 , Pd oxalate, [Pd(NH 3 ) 4 ]X 2 , PdL 2 X, Pd(CO)X, wherein X is Cl, Br or I. A method according to any one of claims 1-4 wherein the oxidising agent is oxygen or air. 6. A method according to any one of claims 1-5 wherein said halogen containing promoter contains iodine. 7. A method according to claim 6 wherein the halogen containing promoter is selected from the group consisting of Nal, Lil, Csl, tetra butyl ammonium iodide, tetra heptyl ammonium iodide, and iodine. 8. A method according to any one of claims 1-7 wherein the proportion of palladium is about 1 mole per 100-500 moles of amino group in the polymeric amine compound. 9. A method according to any one of claims 1-8 wherein the ratio of iodide promoter to catalyst precursor is in the range of about 0.5-15. 10. A method according to any one of claims 1-9 wherein the temperature is about 100° to 300°C temperature is present. 11. A method according to any one of claims 1-10 wherein the pressure is about 10 to 100 bar. 12. A method according to any one of claims 1-11 wherein the reaction is effected in the absence of an inert solvent. 13. A method according to any one of claims 1-11 wherein the reaction is effected in the presence of an inert solvent. 14. A method according to claim 13 wherein said solvent is selected from aromatic hydrocarbons, nitriles, ethers, ketones, amides and esters. 15. A method according any one of claims 1-14 wherein oxygen is present in the reactor and the CO:O 2 ratio in the range of about 5:1 to 20: 1.

Inventors: CHAUDHARI RAGHUNATH VITTHAL, DIVEKAR SUNIL SADASHIV, GANAPATHY SUBRAMANIAN, GUPTE SUNIL PURUSHOTTAM, KELKAR ASHUTOSH ANANT, CHAUDHARI, RAGHUNATH, VITTHAL, DIVEKAR, SUNIL, SADASHIV, GANAPATHY, SUBRAMANIAN, GUPTE, SUNIL, PURUSHOTTAM, KELKAR, ASHUTOSH, ANANT
Applicants: CHAUDHARI RAGHUNATH VITTHAL, DIVEKAR SUNIL SADASHIV, GANAPATHY SUBRAMANIAN, GUPTE SUNIL PURUSHOTTAM, HUNTSMAN ICI CHEM LLC, KELKAR ASHUTOSH ANANT, CHAUDHARI, RAGHUNATH, VITTHAL, DIVEKAR, SUNIL, SADASHIV, GANAPATHY, SUBRAMANIAN, GUPTE, SUNIL, PURUSHOTTAM, HUNTSMAN ICI CHEMICALS LLC, KELKAR, ASHUTOSH, ANANT
Application year: 2000
Main classification: C07C269
IPC codes: C07C269, C07C271, C08G61