COMPOUNDS

Abstract: Use of compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, as serine protease inhibitors.

Description: Compounds This invention relates to compounds that are inhibitors of serine proteases. More particularly, it relates to their use as serine protease inhibitors in the treatment of the human or animal body. The serine proteases are a group of proteolytic enzymes which have a common catalytic mechanism characterized by a particularly reactive Ser residue. Examples of serine proteases include trypsin, tryptase, chymotrypsin, elastase, thrombin, plasmin, kallikrein, Complement Cl, acrosomal protease, lysosomal protease, cocoonase, α-lytic protease, protease A, protease B, serine carboxypeptidase II, subtilisin, urokinase, Factor Vila, Factor IXa, and Factor Xa. The serine proteases have been investigated extensively over a period of several decades and the therapeutic value of inhibitors of serine proteases is well understood. (For a recent review, see, for example, Donmienne Leung et al., J. Med. Chem., Vol. 43, No. 3, 2000, pages 305-341). Serine protease inhibitors play a central role in the regulation of a wide variety of physiological processes including coagulation, fibrinolysis, fertilization, development, malignancy, neuromuscular patterning and inflammation. It is well known that these compounds inhibit a variety of circulating proteases as well as proteases that are activated or released in tissue. It is also becoming clear that serine protease inhibitors inhibit critical cellular processes, such as adhesion, migration, free radical production and apoptosis. In addition, animal experiments indicate that intravenously administered serine protease inhibitors, variants or cells expressing serine protease inhibitors, provide a protective effect against tissue damage. Serine protease inhibitors have also been predicted to have potential beneficial uses in the treatment of disease in a wide variety of clinical areas such as oncology, neurology, haematology, pulmonary medicine, immunology, inflammation and infectious disease. In particular serine protease inhibitors may be beneficial in the treatment of thrombotic diseases, asthma, emphysema, cirrhosis, arthritis, carcinoma, melanoma, restenosis, atheroma, trauma, shock and reperfusion injury. Thus for example an inhibitor of Factor Xa has value as a therapeutic agent as an anticoagulant, e.g. in the treatment and prevention of thrombotic disorders. The use of a Factor Xa inhibitor as an anticoagulant is desirable in view of the selectivity of its effect. Many clinically approved anticoagulants have been associated with adverse events owing to the non-specific nature of their effects on the coagulation cascade. Also, there are well-known associations of αl protease inhibitor deficiency with emphysema and cirrhosis and Cl esterase inhibitor deficiency with angioedema. Tryptase is the major secretory protease of human mast cells and is proposed to be involved in neuropeptide processing and tissue inflammation. Mature human tryptase is a glycosylated, heparin- associated tetramer of catalytically active subunits. Its amino-acid structure appears to have no close counterpart among the other serine proteases which have been characterised. Tryptase is stored in mast cell secretory granules and after mast cell activation, human tryptase can be measured readily in a variety of biological fluids. For example, after anaphylaxis, tryptase appears in the blood stream where it is readily detectable for several hours. Tryptase also appears in samples of nasal and lung lavage fluid from atopic subjects challenged with specific antigen. Tryptase has been implicated in a variety of biological processes where activation and degranulation of mast cells occur. Accordingly, mast cell tryptase inhibition may be of great value in the prophylaxis and treatment of a variety of mast cell mediated conditions. Mast cells can degranulate by both IgE-dependent and independent mechanisms thereby implicating tryptase in both atopic and non-atopic inflammatory conditions. Tryptase can activate proteases such as pro-urokinase and pro-MMP3 (pro-matrix metalloprotease 3, pro-stromelysin) , thereby indicating a pathological role in tissue inflammation and remodelling. Furthermore, the recent evidence that tryptase can activate certain G-protein coupled receptors (eg PAR2) and induce neurogenic inflammation points to a broader physiological role, for example in modulating pain mechanisms. Given tryptase ' s multiple mechanisms of action, it has been proposed that tryptase inhibitors may be beneficial in a broad range of diseases. These include conditions such as: asthma (specifically influencing the inflammatory component, the underlying hyperreactivity, and the chronic fibrotic damage due to smooth muscle thickening) ; chronic obstructive pulmonary disease (COPD) and pulmonary fibrotic diseases; rhinitis; psoriasis; urticaria; dermatitis; arthritis; Crohn's disease; colitis; angiogenesis; atherosclerosis; multiple sclerosis; interstitial cystitis; migraine headache; neurogenic inflammation and pain mechanisms; wound healing; cirrhosis of the liver; Kimura's disease; pre- eclampsia; bleeding problems associated with menstruation and the menopause; cancer (particularly melanoma and tumour metastasis) ; pancreatitis; and certain viral infections (Yong, Exp. Toxic Pathol, 1997, 49, 409; Steinhoff et al . , Nat. Med., 2000, 6, 151; Downing and Miyan, Immunol. Today, 2000, 21, 281; Tetlow and ooley, Ann. Rheum. Dis., 1995, 54, 549; Jeziorska, Salamonsen and Wooley, Biol. Reprod. , 1995, 53, 312; Brain, Nat. Med., 2000, 6, 134; Olness et al . , Headache, 1999, 39, 101.) The underlying principle is that a tryptase inhibitor should have utility where mast cells have being induced to degranulate by whatever mechanism, including anaphylactic reactions due to exogenous substances, e.g. morphine-induced bronchoconstriction (Bowman and Rand, 2 nd edt . , 1980.) It has now been found that certain aromatic compounds carrying lipophilic side chains are particularly effective as inhibitors of serine proteases, especially serine proteases with negatively charged PI specificity pockets, such as factor Xa, thrombin and tryptase. Depending upon their structure, certain of these compounds have been found to be selective for the serine protease, Factor Xa. Others have been found to be dual inhibitors of Factor Xa and thrombin. Yet others have been found to be selective for the serine protease, tryptase. The Factor Xa inhibitors of this invention are potentially useful for the prophylaxis or treatment of thrombotic disorders such as amongst others venous thrombosis, pulmonary embolism, arterial thrombosis, myocardial ischaemia, myocardial infarction, and cerebral thrombosis. They potentially have benefit in the treatment of acute vessel closure associated with thrombolytic therapy and restenosis, e.g. after transluminal coronary angioplasty or bypass grafting of the coronary or peripheral arteries and in the maintenance of vascular access patency in long term hemodialysis patients. Factor Xa inhibitors of this invention may, with benefit, form part of a combination therapy with an anticoagulant with a different mode of action or with a thrombolytic agent. Hence, the invention also provides the use of certain compounds which have been found to be inhibitors of both Factor Xa and thrombin. These compounds have excellent potential therapeutic value and may synergistically boost Fxa antithrombotic effect. It is envisaged that the compounds that are tryptase inhibitors will be useful not only in the treatment and prophylaxis of asthma but also of other allergic and inflammatory conditions mediated by tryptase such as allergic rhinitis, skin conditions such as eczema, psoriasis, atopic dermatitis and urticaria, rheumatoid arthritis, conjunctivitis, inflammatory bowel disease, neurogenic inflammation, atherosclerosis and cancer. It has been reported in W099/11658 and W099/11657 that certain benzamidine and aminoisoquinoline derivatives carrying a bulky lipophilic side chain are excellent inhibitors of serine proteases. Unfortunately, it has since been found that benzamidine compounds of WO 99/11658 in general demonstrate poor oral bioavailability. Surprisingly, it has now been found that certain other aromatic compounds also show inhibitory activity against serine proteases, in particular Factor Xa, despite the lack of the amidino or 1-aminoisoquinoline functionality previously believed to be crucial for activity as a factor Xa inhibitor, thrombin or tryptase. Many of these compounds also possess structural features in addition to the aromatic group or properties (such as activity as tryptase inhibitors) that further distinguish them from the compounds of W099/11658 and W099/11657. Where compounds of the invention have been tested, they have generally demonstrated superior oral bioavailability in comparison with benzamidines disclosed in WO 99/11658. Also, it has been found that Factor Xa inhibitor compounds of the invention perform excellently in the prothrombin time assay (PT) when compared to aminoisoquinolines of similar Factor Xa activity and structure. The PT assay is a coagulation assay and it is widely accepted that direct acting Factor Xa inhibitors which perform well in the PT assay are more likely to be good antithrombotics . In WO99/09053 certain 2-aminobenzamide compounds are disclosed as potential motilin receptor antagonists and in US 3268513 similar 2-aminobenzamide compounds are suggested as potential antibacterial agents. However, the novel compounds of the present invention have not before been suggested as potential serine protease inhibitors. In WO96/09297, W095/32945, WO94/20527 and US 5,525,623 a variety of peptide based compounds are suggested as potential inhibitors of the mast cell protease tryptase. In WO95/03333 a tryptase inhibitor is provided by a polypeptide obtainable from the leech hirudo medicinalis . In WO96/08275 secretory leukocyte protease inhibitor (SLPI) and active fragments thereof have been found to inhibit the proteolytic activity of tryptase. In W099/55661 certain 4- aminomethylbenzoic ester derivatives are proposed as potential tryptase inhibitors. Thus viewed from an one aspect the invention provides a method of treatment of the human or non-human animal body (e.g. a mammalian, avian or reptilian body) to combat a condition responsive to a serine protease inhibitor, said method comprising administering to said body an effective amount of a serine protease inhibitor compound of formula (I) (I) where R2 represents a 5 or 6 membered aromatic carbon ring optionally interrupted by a nitrogen, oxygen or sulphur ring atom, optionally being substituted in the 3 and/or 4 position (in relation to the point of attachment of X-X) by halo, nitro, thiol, haloalkoxy, hydrazido, alkylhydrazido, amino, cyano, haloalkyl, alkylthio, alkenyl, alkynyl, acylamino, tri or difluoromethoxy, carboxy, acyloxy, MeSθ2~ or Rj_, or the substituents at the 3 and 4 positions taken together form a fused ring which is a 5 or 6 membered carbocyclic or heterocyclic ring optionally substituted by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij , and optionally substituted in the position alpha to the X-X group (i.e. 6 position for a six membered aromatic ring etc) by amino, hydroxy, halo, alkyl, carboxy, alkoxycarbonyl , cyano, amido, aminoalkyl, hydroxyalkyl, alkoxy or alkylthio with the proviso that R2 cannot be aminoisoquinolyl; each X independently is a C, N, 0 or S atom or a CO, CRι a , C(Rι a )2 or NR^ a group, at least one X being C, CO, CR la or C(R la ) 2 ; each R^ a independently represents hydrogen or hydroxyl, alkoxy, alkyl, aminoalkyl, hydroxyalkyl alkoxyalkyl, alkoxycarbonyl, alkylaminocarbonyl , alkoxycarbonylamino, acyloxymethoxycarbonyl or alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl; L is an organic linker group containing 1 to 5 backbone atoms selected from C, N, O and S, or a branched alkyl or cyclic group; Y (the α-atom) is a nitrogen atom or a CR k group; Cy is a saturated or unsaturated, mono or poly cyclic, homo or heterocyclic group, preferably containing 5 to 10 ring atoms and optionally substituted by groups R 3a or phenyl optionally substituted by R 3a ; each R 3a independently is Rχ c , amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl, alkylsulphenyl , triazolyl, imidazolyl, tetrazolyl, hydrazido, alkyl imidazolyl, thiazolyl, alkyl thiazolyl, alkyl oxazolyl, oxazolyl, alkylsulphonamido, alkylaminosulphonyl , aminosulphonyl , haloalkoxy and haloalkyl ; Lp is a lipophilic organic group; D is a hydrogen bond donor group; and n is 0, 1 or 2; and Ri, Rib, Rι c and Ri j are as defined for Rι a , or a physiologically tolerable salt thereof, e.g. a halide, phosphate or sulphate salt or a salt with ammonium or an organic amine such as ethylamine or meglumine. As used herein, the term " treatment" includes prophylaxis, amelioration or elimination of a condition for which a human or non-human animal body is being treated. The " effective amount" or dosage of the inhibitor compound of formula (I) will depend upon the nature and severity of the condition being treated, the administration route and the size and species of the patient. However in general, quantities of from 0.01 to 100 μmol/kg bodyweight will be administered. Viewed from a further aspect the invention provides the use of a serine protease inhibitor compound of formula I as defined hereinabove, or physiologically tolerable salt thereof, for the manufacture of a medicament for use in a method of treatment of the human or non-human animal body (e.g. a mammalian, avian or reptilian body) to combat (i.e. treat or prevent) a condition responsive to said inhibitor. The serine protease is preferably a serine protease with a negatively charged PI specificity pocket (i.e. trypsin-like) . It has further been found that compounds of formula (I) in which Ri is an unsubstituted aminoalkyl group, are selective inhibitors of tryptase. Compounds of formula (I) in which R represents other than an unsubstituted aminoalkyl group have been found to be selective inhibitors of Factor Xa, or selective dual inhibitors of Factor Xa and thrombin. According to another aspect, therefore, the present invention provides a method of treatment of the human or non-human animal body (e.g. a mammalian, avian or reptilian body) to combat a condition responsive to a Factor Xa inhibitor (e.g. a condition such as a thrombotic disorder, including venous thrombosis, pulmonary embolism, arterial thrombosis, myocardial ischaemia, myocardial infarction and cerebral thrombosis, acute vessel closure associated with thrombolytic therapy and restenosis, including after transluminal coronary angioplasty or bypass grafting of the coronary or peripheral arteries and in the maintenance of vascular access patency in long term hemodialysis patients) , said method comprising administering to said body an effective amount of a serine protease inhibitor compound of formula (I) as defined hereinabove, provided that Ri is not an unsubstituted aminoalkyl group, or a physiologically tolerable salt thereof. According to another aspect, therefore, the present invention provides a method of treatment of the human or non-human animal body (e.g. a mammalian, avian or reptilian body) to combat a condition responsive to a tryptase inhibitor (e.g. a condition such as asthma, allergic rhinitis, eczema, psoriasis, atopic dermatitis, urticaria, rheumatoid arthritis, conjunctivitis, inflammatory bowel disease, neurogenic inflammation, atherosclerosis or cancer) , said method comprising administering to said body an effective amount of a serine protease inhibitor compound of formula (I) as defined hereinabove which is substituted in the 3 and/or 4 position by R and in which Ri is an unsubstituted aminoalkyl group, or a physiologically tolerable salt thereof. The present invention further provides the use of a serine protease inhibitor compound of formula (I) as defined hereinabove, provided that Ri is not an unsubstituted aminoalkyl group, or a physiologically tolerable salt thereof for the manufacture of a medicament for use as a Factor Xa inhibitor. The present invention further provides the use of a serine protease inhibitor compound of formula (I) as defined hereinabove, which is substituted in the 3 and/or 4 position by Ri and in which Ri is an unsubstituted aminoalkyl group, or a physiologically tolerable salt thereof for the manufacture of a medicament for use as a tryptase inhibitor. In the compounds of formula (I), where the alpha atom is carbon it preferably has the conformation that would result from construction from a D-α-aminoacid NH 2 -CRik(Cy) -COOH where the NH 2 represents part of X-X. Likewise the fourth substituent R J-, at an alpha carbon is preferably a methyl or hydroxy ethyl group or hydrogen. In the compounds of formula (I) , unless otherwise indicated, aryl groups preferably contain 5 to 10 ring atoms optionally including 1, 2 or 3 heteroatoms selected from 0, N and S ; alkyl , alkenyl or alkynyl groups or alkylene moieties preferably contain up to 6 carbons, e.g. Cι_g or c l - 3 '' cyclic groups preferably have ring sizes of 3 to 8 atoms; and fused multicyclic groups preferably contain 8 to 16 ring atoms. Examples of particular values for Rι a are: hydrogen, methyl or ethyl. R a is preferably a hydrogen atom. The linker group from the R2 group to the alpha atom is preferably selected from -CH=CH-, -C0NH-, -C0NRι a -, -NH-CO-, -NH-CH 2 -, -CH 2 -NH-, -CH 2 0-, -0CH 2 -, -C00-, -0C=0- and -CH2CH2-. Preferably, the X moiety nearest to the alpha atom is an NH or 0 atom, most preferably a NH group. The X moiety alpha to the aromatic ring is preferably a carbon based group such as CH 2 or CO, preferably CO. Thus a particularly preferred linker X-X is -CONH-. In an alternative embodiment the linker is preferably a -OCH 2 - grou . Examples of particular values for Ru-, are: hydrogen, (1-4C) alkyl, such as methyl or hydroxy (1-4C) alkyl, such as hydroxymethyl. Rib is preferably a hydrogen atom. The alpha atom (Y) is preferably a CH or C(CH3) group, especially CH. The linker group from the alpha atom to the lipophilic group is preferably CO, CH 2 NH, CONR 1 3 (CH 2 ) m , (CH 2 ) m N(Rι d )CO(CH 2 ) m , (CH 2 ) m+2 , C0(CH 2 ) m , (CH 2 ) m CO, (CH 2 ) m OC=0, (CH 2 ) m O, CH=CH(CH 2 ) m , S0 2 , S0 2 NRι d , S0 2 (CH 2 ) m , (CH2) Sθ 2 or (CH 2 ) m S0 2 NR l d (where each m is independently 0 or 1 and Rι d is as defined for Rι a ) . Examples of particular values for Rι d are: hydrogen; for alkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1-6C) alkyl, such as methyl or ethyl, or aryl (1-6C) alkyl, such as benzyl or phenylethyl; for aminoalkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (2- 6C) carboxamido, such as carboxamidomethyl ; for hydroxyalkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1- 6C) carboxyalkyl, such as carboxymethyl, carboxyethyl or carboxypropyl ; for alkoxyalkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1- 5C) alkoxycarbonyl (1-6C) alkyl , such as methoxycarbonylmethyl , methoxycarbonylethyl , methoxycarbonylpropyl , ethoxycarbonylmethyl , ethoxycarbonylethyl and ethoxycarbonylpropyl . Rι d is preferably a hydrogen atom. The linker may be optionally branched, for example, to incorporate a polar functionality. Examples of particular values for L are CO, CONH, CH 2 NHCO and CONHCH 2 . It will be appreciated by those skilled in the art that a diverse range of organic groups are lipophilic, and that it is therefore impractical to define with precision each and every structure that may be incorporated into a serine protease inhibitor compound of formula (I) . Accordingly, it is being assumed that the addressee of this specification will not require an exhaustive computer listing of structures of lipophilic groups, but will instead make use of the structures of lipophilic groups disclosed in the specification, especially those exemplified; the test systems described herein for identifying serine protease inhibitors; and common general knowledge of the lipophilicity, synthesis and stability of organic compounds, to obtain novel serine protease inhibitor compounds of formula (I) . The lipophilic group may be, for example, an alkyl, alkenyl, carbocyclic or heterocyclic group, or a combination of two or more such groups linked by a spiro linkage or a single or double bond or by C=0, 0, S, SO, S0 , C0NRι e , NR e -C0-, NRι e linkage (where Rι e is as defined for Rι a ) , optionally substituted by one or more oxo or R 3 groups in which R 3 is alkylaminocarbonyl , alkoxycarbonylamino, N- alkylaminoalkanoyl, N-alkanoylaminoalkanoyl , C- hydroxyaminoalkanoyl or as defined for R 3a . By way of illustration, representative lipophilic groups include methylcyclohexyl, methylcyclohexylmethyl, methylphenylmethyl , phenylethyl , benzylpiperidinyl , benzoylpiperidinyl, bispiperidinyl and phenylpiperazinyl . Phenylethyl is an example of a combination of an alkyl group and a carbocyclic group linked through a single bond. Benzylpiperidinyl is an example of a combination of an alkyl group, a carbocyclic group and a heterocyclic group linked by single bonds. Benzoylpiperidinyl is an example of a combination of a carbocyclic group and a heterocyclic group linked through C=0. Methylcyclohexylmethyl is an example of a combination of an alkyl group (methyl) and a carbocyclic group (cyclohexyl) linked by a single bond and having a substituent R 3 (methyl) on cyclohexyl. It will be appreciated that this group could alternatively have been regarded as a combination of two alkyl groups and a carbocyclic group. However, in order to provide clarity, in this specification any terminal alkyl group in Lp will be treated as a substituent R3. When the lipophilic group comprises an alkyl group, this may be, for example, a (1-3C) alkyl group, such as methyl, ethyl or propyl. Preferably an alkyl group is unsubstituted. When the lipophilic group comprises a carbocyclic group, this may be, for example, a non-aromatic or aromatic, mono or polycyclic hydrocarbon group containing up to 25, more preferably up to 10 carbon atoms. The carbocyclic group may thus be, for example, a cycloalkyl, polycycloalkyl, phenyl or naphthyl group, or a cycloalkyl group fused with a phenyl group . Examples of particular values for a cycloalkyl group are (3-6C) cycloalkyl groups, such as cyclopentyl and cyclohexyl. A cycloalkyl group is preferably unsubstituted or substituted by one group R 3 , preferably amino or an alkyl group, such as methyl. Examples of particular values for a polycycloalkyl group are (6-10C) polycycloalkyl groups, such as bicycloalkyl, for example decalinyl, norbornyl or adamantyl . A polycycloalkyl group is preferably unsubstituted or substituted by one, two or three R 3 groups, for example alkyl such as methyl . An example of a polycycloalkyl group substituted by alkyl is isopinocamphenyl . A phenyl group is preferably unsubstituted or substituted by one or two R 3 groups. More preferably it is substituted by one or two R 3 groups. A naphthyl group is preferably unsubstituted or substituted by one R 3 group. Examples of a cycloalkyl or cycloalkenyl group fused with a phenyl group are indanyl and tetrahydronaphthyl . This group is preferably unsubstituted or substituted by oxo or one or two R 3 groups. Examples of groups substituted by oxo are l-oxoindan-5-yl, l-oxo-5, 6, 7, 8-tetrahydronaphth-5-yl and l-oxo-5, 6,7, 8-tetrahydronaphth-6-yl . When the lipophilic group comprises a heterocyclic group, this may be, for example, a non-aromatic or aromatic, mono or polycyclic group containing one or two oxygen, nitrogen or sulfur atoms in the ring system, and in total up to 25, more preferably up to 10 ring system atoms. Examples of a heterocyclic group when it is a non- aromatic monocyclic group are azacycloalkyl groups, such as pyrrolidinyl and piperidinyl; azacycloalkenyl groups, such as pyrrolinyl; diazacycloalkyl groups, such as piperazinyl; oxacycloalkyl groups, such as tetrahydropyranyl ; and thiacycloalkyl groups, such as tetrahydrothiopyranyl . A non- aromatic monocyclic group preferably contains 5, 6 or 7 ring atoms and is preferably unsubstituted or substituted by one group R 3 , preferably alkyl, such as methyl or ethyl, or hydroxyalkyl , such as hydroxymethyl . Examples of a heterocyclic group when it is a non- aromatic polycyclic group are bicyclic groups, such as azacycloalkyl fused with phenyl, for example dihydroindolyl , dihydroisoindolyl, tetrahydroquinolinyl and tetrahydroisoquinolinyl; azacycloalkyl fused with cycloalkyl, such as decahydroisoquinolyl , and tricyclic groups, such as azacycloalkyl fused with indolyl, for example tetrahydropyrido [3 , 4-b] indole . This group is preferably unsubstituted. Examples of a heterocyclic group when it is an aromatic monocyclic group are furyl, pyrrolyl, thienyl, imidazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, oxazolyl, oxadiazolyl (such as 1, 3 , 4-oxadiazolyl) , thiadiazolyl (such as 1, 3 ,4-thiadiazolyl) , triazinyl and thiazolyl. This group is preferably unsubstituted or substituted by one or two R 3 groups . Examples of a heterocyclic group when it is an aromatic polycyclic group are bicyclic groups such as benzofuryl, quinolinyl, isoquinolinyl, benzothienyl , indolyl and benzothiazolyl . This group is preferably unsubstituted or substituted by one R 3 . The lipophilic group preferably comprises a cycloalkyl, azacycloalkyl, diazacycloalkyl, phenyl, naphthyl, adamantyl, bicycloalkyl, mono- or diazabicycloalkyl, mono- or bicyclo heteroaromatic or a linear or branched alkyl or alkenyl group all optionally substituted by one or more oxo or groups R3 , or a combination of at least two such groups linked by a spiro linkage or a single or double bond or by C=0, 0, S, SO, SO2, C0NRι e , NRι e -C0- or NR ie linkage (where R e is as defined for Rι a ) . Where Lp comprises a combination of at least two groups, it preferably comprises a combination of two or three such groups. The groups are preferably linked by a single bond, C=0, 0 or NR le . Examples of particular values for Rι e are hydrogen and (1-6C) alkyl, such as methyl or ethyl. The lipophilic group Lp may be selected, for example, from: wherein R 3 is as hereinbefore defined; m represents 0 or 1; R 4 represents hydrogen, (CH 2 ) w COOH or (CH 2 ) w CONH 2 ; w represents an integer from 0 to 4; and X represents CH or N. Where two or more X atoms are present in a ring, preferably at least one is CH. In the Lp groups depicted above, preferably L represents CO when the Lp group is linked to L through N, or CONH when the Lp group is linked to L through C. Examples of particular values for R 3 are:- for alkylaminocarbonyl : N-methyl-N-ethylaminocarbonyl , methylaminocarbonyl or dimethylaminocarbonyl ; for N-alkylaminoalkanoyl : N-methylacetyl ; for N-alkanoylaminoalkanoyl : 2-N-acetylaminoacetyl or 2-N- acetylaminopropanoyl ; for C-hydroxyaminoalkanoyl : 2-amino-3-hydroxypropanoyl or 2- amino-3 -hydroxybutanoyl ; hydrogen; hydroxyl ; for alkoxy optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: alkoxy such as methoxy or ethoxy; for alkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1-6C) alkyl, such as methyl, ethyl, propyl, 2 -propyl, butyl, 2 -butyl, t-butyl, pentyl, 2-pentyl or 3 -pentyl, (1-6C) alkylamino (1-6C) alkyl , such as isopropylaminomethyl , dimethylamino-methyl, diethylaminomethyl or dimethylaminoethyl , or (1-6C) alkanoyl , such as acetyl, propionyl or isobutyryl; for hydroxyalkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1- 6C) hydroxyalkyl , such as hydroxymethyl, or 1-hydroxyethyl or 2-hydroxyethyl, carboxy, carboxy (1-5C) alkyl or hydroxy (1- 6C) alkanoyl, such as 2-hydroxyacetyl or 2-hydroxypropanoyl; for alkoxyalkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1-6C) alkoxy (1- 6C) alkyl, such as methoxymethyl ; for alkoxycarbonyl : methoxycarbonyl or ethoxycarbonyl : for aminoalkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: amino(l- 6C) alkyl such as aminomethyl, aminocarbonyl , aminocarbonyl- (1-5C) alkyl, or amino (1-6C) alkanoyl , such as aminoacetyl (COCH 2 NH 2 ) , aminopropionyl (COCH 2 CH 2 NH 2 ) or 2-aminopropionyl (COCH(CH 3 )NH 2 ) ; for alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1- 6C) alkylamino such as methylamino, dimethylamino or ethylamino, or (1-6C) alkanoylamino, such as formylamino or acetylamino; amino; for halo: fluoro or chloro; cyano; nitro; thiol; for alkylthio: methylthio; for alkylsulphonyl : methylsulphonyl, ethylsulphonyl or isopropylsulphonyl ; for alkylsulphenyl : methylsulphenyl ; for triazolyl: 1, 2 , 4-triazol-2-yl , 1, 2 , 4-triazol-4-yl or 1,2, 3-triazol-4-yl; for imidazolyl: 1, 3-imidazol-l-yl or 1, 3-imidazol-4-yl ; for tetrazolyl: tetrazol-1-yl or tetrazol-5-yl; hydrazido; for alkylsulphonamido: methylsulphonamido, ethylsulphonamido or propylsulphonamido; for alkylaminosulphonyl : methylaminosulphonyl , ethylaminosulphonyl or propylaminosulphonyl ; aminosulphonyl ; for haloalkoxy: trifluoromethoxy; and for haloalkyl: trifluoromethyl or trichloromethyl . When R 3 is present as a substituent on an aromatic ring, it may be selected, for example, from hydrogen, alkylsulphonyl, aminosulphonyl, alkylaminosulphonyl, alkylaminocarbonyl , amino, amido, alkoxycarbonyl, acetylamino, chloro, fluoro, cyano, methoxy, ethoxy, nitro, hydroxy, alkylsulphonylamino, triazolyl and tetrazolyl. When R 3 is present as a substituent on a saturated ring, it may be selected, for example, from hydrogen, hydroxy, amino, (1-3C) alkoxy, (1-3C) hydroxyalkyl , (1- 3C) alkyl, carboxy, methoxycarbonyl and ethoxycarbonyl . It has been found that certain groups L and, especially, Lp are associated with selectivity for Factor Xa, whereas others are associated with selectivity for tryptase . One group of compounds of particular interest as Factor Xa inhibitors are compounds of formula (I) in which Lp comprises an azacycloalkyl or diazacycloalkyl group of formula in which r is 1 or 2, one of X a and Xfc is N and the other is CH or N, provided that when r is 1, X a and Xj-, are no t bo h N. Preferred compounds comprising this group are those in which Lp is a group of formula: in which: r is 1 or 2; one of X a and X]-, is N and the other is CH or N provided that when r is 1, X a and Xfc are not both N; s , t and u are each 0 or 1 ; L a and L]-, are each independently selected from a single bond, C=0, 0 and NRι e , in which Rι e is hydrogen or (1- 6C) alkyl; G is (l-6C)alkanediyl; and Rχo is (1-6C) alkyl ; (3 -6C) cycloalkyl which is unsubstituted or substituted by (1-6C) alkyl ; indanyl; pyridyl; tetrahydropyranyl ; tetrahydrothiopyranyl ; phenyl which is unsubstituted or substituted by one or two R 3 groups; pyrrolinyl; or a group of formula in which v is 1, 2 or 3 ; one of X c and X d is N and the other is CH or N, provided that when v is 1, X c and X d are not both N; and R^ is hydrogen, (1-6C) alkyl or when X d is CH, hydroxy (1-6C) alkyl; provided that when t is 0, the sum of s and u is 1; when X^ is N, L a is a bond or C=0; when X c is N, L]-) is a bond or C=0; when X^ and X c are both N, t is 1; and when (L a ) s - (G) t - (L b ) represents an alkyl group and X b and X c both represent N, the alkyl group contains at least two chain carbon atoms . It will be appreciated that the provisos exclude compounds having two heteroatoms bonded directly together or separated by an alkyl group having only one carbon atom in the chain. When X a is N, L is preferably CO or CH 2 CO. When X a is CH, L is preferably CONH, CONHCH 2 or CH 2 NHCO. Examples of values for G are CH2 , (CH2)2 an< 3 (0^) 3 . Examples of values for R^ are hydrogen, methyl, ethyl or 2-propyl, or when X d is CH, hydroxymethyl. Examples of values for R]_Q are: for (1-6C) alkyl: methyl, ethyl, 2-propyl and 3-pentyl; for (3-6C) cycloalkyl which is unsubstituted or substituted by (1-6C) alkyl: cyclopentyl, 3 -methylcyclopentyl , cyclohexyl and 4-methylcyclohexyl; for indanyl : 2-indanyl; for pyridyl: pyrid-2-yl, pyrid-3-yl and pyrid-4-yl; for tetrahydropyranyl : tetrahydropyran-4-yl ; for tetrahydrothiopyranyl : tetrahydrothiopyran-4-yl; for phenyl which is unsubstituted or substituted by one or two R3 groups: phenyl, 2-fluorophenyl, 3-fluorophenyl , 4- fluorophenyl, 2- (methylthio) phenyl , 2-ethylphenyl , 2- methoxyphenyl , 3-methoxyphenyl, 4-methoxyphenyl , 2- methanesulphonylphenyl , 3-methanesulphonylphenyl, 4- methanesulphonylphenyl , 4-fluoro-2-methanesulphonylphenyl , 4-amino-2-methanesulphonylphenyl, 4-amido-2- methanesulphonyl-phenyl, 4-nitro-2 -methanesulphonylphenyl , 2-aminosulphonylphenyl, 2-methylaminosulphonylphenyl , 2- dimethylaminosulphonylphenyl , 2 -methylsulphonylamino-phenyl , 2 -carboxamidophenyl and 2 -acetamidophenyl ; for pyrrolinyl: pyrrolin-1-yl ; and for a group of formula piperidin-l-yl, 4-methyl-piperidin-l-yl, piperidin-4-yl, 1- methylpiperidin-4-yl, 1- (2-propyl) piperidin-4-yl , pyrrolidin-1-yl, 3 -methylpyrrolidin-1-yl , pyrrolidin-3-yl , l-methyl-pyrrolidin-3-yl, 1- (2-propyl) pyrrolidin-3-yl , 1- methyl-piperazin-4-yl, l-ethylpiperazin-4-yl , 1- (2- propyl)piperazin-4-yl, hexahydro-1, 4-diazapin-l-yl and 4- methyl-hexahydro-1, 4-diazapin-l-yl . Another group of compounds of particular interest as Factor Xa inhibitors are compounds of formula (I) in which -L-Lp(D) n is q is 1 or 2; (a) Q is a direct bond; and Rg is piperidin-4-yl which may bear a C]__ 3 alkyl substituent at the 1-position; or Rg is R a Rk in which each of R a and R]-, independently is hydrogen or Cι_3alkyl; or one of R a and R]-, is hydrogen or methyl and the other of R a and RJ- J is -CH2-R C or-CH2-R(j in which R c is pyridyl or phenyl (which phenyl may bear a fluoro, chloro, methyl, CONH 2 , S0 2 NH 2 , methylaminosulphonyl , dimethylammosulphonyl, methylsulphonylamino, methoxy or methylsulphonyl substituent) and in which R^ is isopropyl or cyclopentyl, or NR a Rfc, is pyrrolidino, piperidino, morpholino, piperazino, or tetrahydro-1, 4-diazepino in which a pyrrolidino or piperidino may be a 3 , 4-didehydro deriviative and in which a pyrrolidino, piperidino, piperazino, or tetrahydro-1, 4-diazepino may bear a methyl group at the 4-position (preferably R q is piperidin-4-yl which may bear a (1-3C) alkyl substituent at the 1-position) ; (b) Q is -0- or -NH- ; and Rg is R c which is defined as above (R c is preferably pyrid-2-yl, pyrid-3-yl or pyrid-4-yl) ; or (c) Q is methylene; and Rg is NR a Rk which is defined as above . q is preferably 2. Another group of compounds of particular interest as Factor Xa inhibitors are compounds of formula (I) in which -L-Lp(D) n is in which R r is -(CH2) C -R c -CHR e Rf, -CH -CHR e Rf, or Rg in which c is 1 or 2 and R c is defined as above; each of R e and Rf independently is hydrogen or Cι_ 3 alkyl; or CHR e Rf is cyclopentyl (which may bear a methyl, ethyl or hydroxymethyl substituent at the 3- or 4-position) , cyclohexyl (which may bear a methyl, ethyl or hydroxymethyl substituent at the 3- or 4-position) , tetrahydropyran-4-yl, tetrahydrothiopyran-4- yl, pyrrolidin-3-yl (which may bear a 1-methyl substituent) , piperidin-4-yl (which may bear a 1-methyl substituent) , or indan-2-yl; and Rg is 2-methylsulphonylphenyl which may bear a 4-fluoro substituent or R g is λ 6 -l,l- dioxobenzo [b] thiophen-7-yl . Preferably c is 2. Preferably R c is pyrid-2-yl, pyrid-3-yl or pyrid-4-yl. Another group of compounds of particular interest as Factor Xa inhibitors are compounds of formula (I) in which -L-Lp(D) n is in which q is 1 or 2; s is 0 or 1; and R s is -(CH2) C -R C . -CHR e Rf, or -CH 2 -CHR e Rf each of which is defined as above. Preferably s is 1. Another group of compounds of particular interest as Factor Xa inhibitors are compounds of formula (I) in which -L-Lp(D) n is in which Rj- is piperidin-4-yl , piperidin-3-yl or pyrrolidin- 3-yl (especially piperidin-4-yl) , any of which may bear a C__ 3 alkyl substituent at the 1-position (preferably methyl, ethyl or, more preferably, 2-propyl) ; or R^ is phenyl (which phenyl may bear a fluoro, chloro, C 1 -. 4 alkyl, methoxy or methylsulphonyl substituent) . Another group of compounds of particular interest as Factor Xa inhibitors are compounds of formula (I) in which -L-Lp(D) n is in which Het is a divalent 5 membered heteroaromatic group containing 1, 2 or 3 heteroatoms selected from 0, N and S and having the two ring atoms at which it is connected separated by one ring atom; h is 0 or 1; and R^ is phenyl which may bear one or more R 3 substituents, for example independently selected from, for an ortho or a para substituent: C 1 -. 5 alkyl, fluoro, chloro, difluoromethyl, trifluoromethyl , methoxy, dimethylamino, methylsulphonyl, and C^_2 acyl, and for a meta substituent: fluoro, chloro and methyl. Within this sub-group, a particularly preferred group of compounds is that in which -L-Lp(D) n is in which R^ is phenyl which may bear one or two R 3 substituents, for example an ortho and/or a para substituent independently selected from, for an ortho: methyl, fluoro, chloro, methylsulphonyl and acetyl, and for a para substituent: methyl, fluoro, chloro, methoxy and dimethylamino; ,ι is S, Z 2 is CH, h is 0; or Z]_ is NH, Z2 is N, h is 1. One group of lipophilic groups Lp that has been found to be associated with Factor Xa inhibitor activity is that of formula in which L x represents 0 or NH. Examples of specific lipophilic groups of interest in Factor Xa inhibitors include where Rg is as defined for R 3 (preferably as defined for a substituent on an aromatic ring) , especially where Rg represents H, OMe, Sθ2 e, F, cyano, amido, amino, NO 2 , Cl or OH; and R is hydrogen or (1-6C) alkyl (such as methyl, ethyl or 2-propyl) . Another highly preferred lipophilic group in compounds of interest as Factor Xa inhibitors is of formula (DP) (DP) wherein A represents N or CH (preferably N) and R 3 is as hereinbefore defined. When the lipophilic group is (DP) it is preferred that the group L represents CO, CH 2 or SO 2 . Also, it is preferred if the R 3 groups in the formula DP are hydrogen . Hence, preferred compounds of formula (I) for use as Factor Xa inhibitors are those of formula (J) (J) where R 2 , X-X, and Cy are as hereinbefore defined and L represents CO, CH 2 or SO 2 . Another highly preferred lipophilic group in Factor Xa inhibitors is based on the formula (K) (K) wherein X 2 is halo, hydrogen, amino, nitro or CONH 2 . Preferably X 2 is hydrogen or fluoro. Compounds in which the lipophilic group is based on the formula (K) or (J) have been found to perform relatively well in the prothrombin time assay, when compared with corresponding aminoisoquinolines of W099/11657. One group of compounds of particular interest as tryptase inhibitors is that in which L represents CO and Lp represents In this group of compounds, R 3 preferably represents hydrogen, hydroxyl or alkylaminocarbonyl . Examples of particular values for Lp in this sub-group are pyrrolidin-1-yl, piperidin-1-yl, 3-N-methyl, N- ethylaminocarbonylpiperidin-1-yl , decahydroisoquinolin-2-yl and 2, 3-dihydroindol-l-yl . Another group of compounds of particular interest as tryptase inhibitors is that in which L represents CONH and Lp represents such as in which X is CH or N. In this group of compounds, R 3 is preferably hydrogen, amino, hydroxy, alkyl or aminoalkyl. Examples of particular values are: (i) 2-aminocyclohexyl or 4 -aminomethylcyclohexyl ; ( ii ) adamanty1 ; (iii) 2-aminobenzothiazol-6-yl; (iv) quinolin-3-yl ; (v) 4 -piperidin-1-ylphenyl or 4-piperazin-l-ylphenyl; (vi) l-oxoindan-5-yl; (vii) indan-5-yl; (viii) tetrahydronaphth-6-yl or 1 -methyltetrahydronaphth-6- yl; (ix) l-oxotetrahydronaphth-6-yl or l-oxotetrahydronaphth-7- yi; (x) 2 , 3 -dimethylindol- 5-yl; and (xi) (N-benzyl-3-acetylindol-5-yl or N-benzyl-3-acetylindol- 7-yl. Another group of compounds of particular interest as tryptase inhibitors is that in which L represents CONH and Lp represents in which R 3 is alkylammocarbonyl, N-alkylaminoalkanoyl , N- alkanoylaminoalkanonyl , C-hydroxyaminoalkanoyl , hydrogen, alkoxy, alkyl, aminoalkyl, aminocarbonyl , hydroxyalkyl, alkoxyalkyl , alkoxycarbonyl , acyloxymethoxycarbonyl , alkylamino, amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl, alkylsulphenyl , triazolyl, imidazolyl, tetrazolyl, hydrazido, alkyl imidazolyl, thiazolyl, alkyl thiazolyl, alkyl oxazolyl, oxazolyl, alkylsulphonamido, alkylaminosulphonyl, aminosulphonyl, haloalkoxy or haloalkyl . Preferably the phenyl group is unsubstituted or substituted by one or two R 3 groups. Examples of particular values are phenyl, 3-cyano-4- methylphenyl , 3-aminocarbonylphenyl, 4-aminocarbonyl-phenyl, 4-chloro-3 -aminocarbonyl-phenyl, 4-chlorophenyl, 3,5- dichlorophenyl , 3-aminomethylphenyl, 4-methyl-3- acetylaminophenyl , 4- (1-hydroxethyl) phenyl and 4- isopropylphenyl . Another particular group of compounds of formula I of interest as tryptase inhibitors is that in which L represents CONH and Lp represents in which R 3x represents R 3 or a group of formula -(CO) p -(G 1 )-R j in which p is 0 or 1; G λ represents (1-3C) alkanediyl or, when p is 1, a bond; and R j represents a carbocyclic or heterocyclic group, optionally substituted by R 3 . It will be appreciated that when Lp represents a group as described above, it corresponds to a group in which Lp is a combination of a heterocyclic group (2 , 3 -dihydroindolyl) , a carbocyclic or heterocyclic group (R j ) and optionally an alkyl group (G x ) , which groups are linked by a single bond or a carbonyl group. Accordingly, examples of particular values for R j are the examples given above for a carbocyclic or heterocyclic group forming part of Lp. Particular mention may be made of pyyrolidinyl , such as pyrrolidin-1- yl, phenyl, thiazolyl, such as thiazol-4-yl , imidazolyl, such as imidazol-4-yl, and pyridyl, such as pyrid-2-yl, pyrid-3-yl and pyrid-4-yl. Examples of values for G are -CH 2 -, and CH 2 CH 2 . The 2, 3 -dihydroindolyl group in the above formula is preferably a 2 , 3-dihydroindol-5-yl or -6-yl group, especially a 2, 3-dihydroindol-6-yl group. Examples of structures of compounds comprising a 2,3- dihydroindolyl group as described above are : When R 3 is a substituent on the 1-position of a 2,3- dihydroindolyl group, it preferably represents alkylammocarbonyl ; N-alkylaminoalkanoyl ; N- alkanoylaminoalkanonyl ; C-hydroxyaminoalkanoyl ; hydrogen; alkyl ; alkanoyl ; alkoxycarbonyl ; acyloxymethoxycarbonyl ; aminoalkyl ; aminoalkanoyl ; hydroxyalkyl ; hydroxyalkanoyl ; alkoxyalkyl; or alkanoylamino. Examples of particular values are: N-methylaminoacetyl, N-acetylaminoacetyl, N- acetylalaninoyl, serinoyl, threoninoyl, hydrogen, methyl, acetyl, propanoyl, 2-methylpropanoyl, 3-methylbutyryl, 2- hydroxypropanoyl , hydroxyacetyl , aminoacetyl and alaninoyl . Accordingly, examples of particular values for Lp are: 1- (N-methylaminoacetyl) -2, 3-dihydroindol-6-yl; 1- (N- acetylaminoacetyl) -2 , 3-dihydroindol-6-yl; 1- (N- acetylalaninoyl) -2, 3-dihydroindol-6-yl ; 1- (serinoyl) -2,3- dihydroindol-6-yl ; 1- (threoninoyl) -2 , 3-dihydroindol-6-yl ; 2, 3-dihydroindol-5-yl; l-methyl-2 , 3-dihydroindol-6-yl ; 1- acetyl-2 , 3-dihydroindol-6-yl; l-propanoyl-2 , 3-dihydroindol- 6-yl; 1- (2-methylpropanoyl) -2, 3-dihydroindol-6-yl ; ; l-(3- methylbutyryl) -2 , 3 -dihydroindol-6-yl; 1- (2-hydroxpropanoyl) - 2, 3-dihydroindol-6-yl; l-hydroxacetyl-2 , 3 -dihydroindol-6-yl ; l-aminoacetyl-2 , 3 -dihydroindol-6-yl and l-alaninoyl-2 , 3- dihydroindol-6-yl . When R 3 is a substituent on a phenyl, thiazolyl, imidazolyl or pyridyl group, it is preferably hydrogen, amino, alkyl or aminoalkyl. Examples of particular values are hydrogen, amino, alkyl or aminomethyl . Accordingly, further examples of particular values for Lp are: 2 , 3 -dihydroindol-5-yl, l-prolinoyl-2 , 3 -dihydroindol- 6-yl, 1-phenylacetyl-2, 3-dihydroindol-6-yl, 1- (2- hydroxy) phenylacetyl-2 , 3-dihydroindol-6-yl, 1- (3 - hydroxy) phenylacetyl-2 , 3 -dihydroindol-6-yl , 1- (4- hydroxy) phenylacetyl-2, 3-dihydroindol-6-yl, 1- (4- pyridyl) acetyl-2, 3 -dihydroindol-6-yl, 1- (3 -pyridyl) acetyl- 2, 3-dihydroindol-6-yl, l-imidazol-4-ylacetyl-2 , 3- dihydroindol-6-yl, 1- (2-aminothiazol-4-yl) acetyl-2 , 3- dihydroindol-6-yl, and 1- (2-formamidothiazol-4-yl) acetyl- 2 , 3 -dihydroindol-6-yl . The hydrogen bond donor group which may be attached to the lipophilic group preferably has a nitrogen or oxygen atom as the hydrogen bearing donor atom and conveniently is a hydroxyl group, a primary, secondary or tertiary amine, or a primary or secondary imine group (as part of an amidine or guanidine) or a saturated or unsaturated heterocyclic group containing a ring nitrogen, preferably a group containing 5 to 7 ring atoms. Where the donor atom is a ring nitrogen, the remote portion of the heterocyclic ring may be part of the lipophilic group. The cyclic group attached to the alpha carbon is preferably an optionally R 3a substituted phenyl, pyridyl (such as pyrid-2-yl, pyrid-3-yl or pyrid-4-yl), thienyl (such as thien-2-yl or thien-3-yl) , thiazolyl (such as thiazol-2-yl, thiazol-4-yl or thiazol-5-yl) , naphthyl (such as naphth-1-yl) , piperidinyl (such as piperidin-4-yl) or cycloalkyl, such as a cyclohexyl group. Examples of particular values for R 3a are : - hydrogen; hydroxyl ; for alkoxy: methoxy or ethoxy; for alkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: alkyl, such as methyl or ethyl, or alkylaminoalkyl , such as methylaminomethyl or dimethylaminomethyl ; for hydroxyalkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: hydroxymethyl or carboxy; for alkoxyalkyl : methoxymethyl ; for alkoxycarbonyl : methoxycarbonyl or ethoxycarbonyl ; for alkylammocarbonyl : methylaminocarbonyl or dimethylaminocarbonyl ; for aminoalkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: aminomethyl, CONH 2 , CH 2 CONH 2 or aminoacetyl; for alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1- 6C) alkanoylamino, such as formylamino or acetylamino; for alkoxycarbonylamino: methoxycarbonylamino, ethoxycarbonylamino or t-butoxycarbonylamino; amino ; for halo: fluoro or chloro; cyano; nitro; thiol ; for alkylthio: methylthio; for alkylsulphonyl : methylsulphonyl or ethylsulphonyl ; for alkylsulphenyl : methylsulphenyl ; for imidazolyl: imidazol-4-yl ; hydrazido; for alkylimidazolyl : 2-methylimidazol-4-yl ; for alkylsulphonamido: methylsulphonylamido or ethylsulphonylamido; for alkylaminosulphonyl : methylaminosulphonyl or ethylaminosulphonyl ; aminosulphonyl ; for haloalkoxy: trifluoromethoxy; and for haloalkyl: trifluoromethyl . Examples of particular values for R ] _ c are: hydrogen; hydroxyl ; for alkoxy: methoxy or ethoxy; for alkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: alkyl, such as methyl or ethyl, or alkylammoalkyl, such as methylaminomethyl or dimethylaminomethyl ; for hydroxyalkyl : hydroxymethyl ; for alkoxyalkyl : methoxymethyl ; for alkoxycarbonyl : methoxycarbonyl or ethoxycarbonyl ; for alkylammocarbonyl : methylaminocarbonyl or dimethylaminocarbonyl ; for alkoxycarbonylamino: methoxycarbonylamino, ethoxycarbonylamino or t-butoxycarbonylamino; for alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: (1- 6C) alkanoylamino, such as formylamino or acetylamino; and for aminoalkyl substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: aminomethyl, CONH 2 , CH 2 CONH 2 or aminoacetyl . Cy is preferably unsubstituted or substituted by one or two R 3a groups. Preferably R 3a is hydrogen, hydroxyl, methoxy, methyl, amino, aminomethyl, hydroxymethyl, formylamino, acetylamino, aminoacetyl, fluoro, chloro, ethylsulphonylamino, amido or methylaminocarbonyl . Examples of particular values for Cy are phenyl, 4- aminophenyl, 4-amidophenyl, 4- (N-methyl) amidophenyl , 4-(N,N- dimethyl) amidophenyl, 2-chlorophenyl, 2-methylphenyl , 2- fluorophenyl, 3 -fluorophenyl , 4 -fluorophenyl, 4- hydroxyphenyl , 2-methoxyphenyl, 4-methoxyphenyl, 3- aminomethylphenyl , 4-aminomethylphenyl, 2- hydroxymethylphenyl , 3-hydroxymethylphenyl, 4- hydroxymethylphenyl, 4-carboxyphenyl , 3- ethylsulphonylaminophenyl, thien-2-yl, thien-3-yl, thiazol- 4-yl, thiazol-5-yl, 2-methylthiazol-4-yl , 2-aminothiazol-4- yl, 2-formylaminothiazol-4-yl, 2-aminothiazol-5-yl , 2- formylaminothiazol-5-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, 4-aminopyrid-3-yl, 4-aminopyrid-4-yl, piperidin-4-yl, 1- methylpiperidin-4-yl, cyclohexyl and naphth-1-yl. Referring to the group R 2 , examples of a 5 or 6 membered aromatic carbon ring optionally interrupted by a nitrogen, oxygen or sulphur ring atom are phenyl; pyrrolyl, such as 2 -pyrrolyl; pyridyl, such as 3 -pyridyl; pyrazinyl, such as 2-pyrazinyl; furyl , such as 2-furyl; and thienyl, such as 2-thienyl or 3-thienyl. Preferably the ring is interrupted (i.e. a carbon atom is replaced) by at most one heteroatom. More preferably the ring is phenyl, 2-thienyl or 2-pyrrolyl. Most preferably, the ring is phenyl. When the ring is phenyl, the group R 2 may be a group of formula in which R 5 is amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen, and Rg and R 7 which may be the same or different represent halo, nitro, thiol, cyano, haloalkyl, haloalkoxy, amido, hydrazido, amino, alkylthio, alkenyl, alkynyl or R^_ or taken together form a 5 or 6 membered fused carbocyclic ring or 5 membered heterocyclic ring, which may itself be substituted by Rij , amino, halo, cyano, nitro, thiol, alkylthio, haloalkyl, haloalkoxy. When the substituents at the 3 and 4 positions taken together form a fused ring which is a 5 or 6 membered carbocyclic or heterocyclic ring, examples of the resultant bicyclic ring are naphthyl, such as 2-naphthyl; benzimidazolyl, such as benzimidazol-5-yl or benzimidazol-6- yl ; isoquinolinyl , such as isoquinolin-7-yl; indolyl , such as indol-2-yl, indol-5-yl or indol-6-yl; indazolyl, such as indazol-5-yl; indazol-6-yl ; 3 , 4-methylenedioxyphenyl ; dihydroindolyl, such as 2 , 3 -dihydroindol-6-yl ; benzothiazolyl, such as benzothiazol-2-yl or benzothiazol-6- yl ; benzo [b] thiophenyl, such as benzo [b] thiophen-2-yl; benzofuryl, such as benzofur-2-yl ; imidazo [1, 2- a] pyrimidinyl, such as imidazo [1, 2 -a] pyrimidin-2-yl; tetrahydroimidazo [1, 2-a] pyrimidinyl, such as tetrahydroimidazo [1, 2-a] pyrimidin-2-yl ; and benzisoxazolyl, such as benzisoxazol-5-yl . R 2 preferably represents: (i) phenyl optionally being substituted in the 3 and/or 4 position by halo, nitro, thiol, haloalkoxy, hydrazido, alkylhydrazido, amino, cyano, haloalkyl, alkylthio, alkenyl, alkynyl, acylamino, tri or difluoromethoxy, carboxy, acyloxy, eSθ 2 ~ or R^, and optionally substituted at the 6 position by amino, hydroxy, halo, alkyl, carboxy, alkoxycarbonyl, cyano, amido, aminoalkyl, alkoxy or alkylthio; (ii) naphth-2-yl optionally substituted at the 6 or 7 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or R_ j and optionally substituted at the 3 position by amino, hydroxy, halo, alkyl, carboxy, cyano, amido, aminoalkyl, alkoxy or alkylthio; (iii) isoquinolin-7-yl, indol-5-yl, indol-6-yl, indazol-5-yl, indazol-6-yl, benzothiazol-6-yl or benzisoxazol-5-yl optionally substituted at the 3 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij ; (iv) benzimidazol-5-yl or benzothiazol-6-yl optionally substituted at the 2 position by amino; (v) thien-2-yl or thien-3-yl optionally substituted at the 4 or 5 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or R^ ; (vi) 3 , 4-methylenedioxyphenyl, 2 , 3 -dihydroindol-6-yl , 3 , 3-dichloro-2-oxo-indol-6-yl or l-methyl-3-aminoindazol-5- yi ; (vii) benzothiazol-2-yl , imidazo [1 , 2-a] pyrimidin-2-yl or tetrahydroimidazo [1, 2-a] pyrimidin-2-yl ; (viii) pyrazol-2-yl optionally substituted at the 5 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or R]_; (ix) pyrid-2-yl optionally substituted at the 5 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or R^ ; (x) pyrid-3-yl optionally substituted at the 6 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or R^; (xi) benzofur-2-yl optionally substituted at the 3 position by amino, hydroxy, halo, alkyl, carboxy, cyano, amido, aminoalkyl, alkoxy or alkylthio and at the 5 or 6 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri ; (xii) indol-2-yl optionally substituted on the indole nitrogen atom by alkyl and optionally substituted at the 5 or 6 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri j ; (xiii) indol-6-yl substituted at the 5 position by amino, hydroxy, halo (such as fluoro or chloro), alkyl, carboxy, alkoxycarbonyl, cyano, amido, aminoalkyl, alkoxy or alkylthio and optionally substituted at the 3 position by halo (such as chloro), haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri j ; or (xiv) benzo [b] thiophen-2-yl optionally substituted at the 3 position by amino, hydroxy, halo, alkyl, carboxy, cyano, amido, aminoalkyl, alkoxy or alkylthio and at the 5 or 6 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij. Examples of particular values for substituents that may be present on R 2 are : for halo: fluoro, chloro, bromo or iodo; nitro; thiol; for haloalkoxy: difluoromethoxy or trifluoromethoxy; hydrazido; for alkylhydrazido: methylhydrazido; amino; cyano; for haloalkyl: trifluoromethyl ; for alkylthio: methylthio; for alkenyl: vinyl; for alkynyl : ethynyl ; for acylamino: acetylamino; carboxy; for acyloxy: acetoxy; hydroxy; for alkyl : methyl or ethyl ; amido (CONH 2 ) ; for aminoalkyl : aminomethyl ; and for alkoxy: methoxy or ethoxy. Examples of particular values for Ri are: hydrogen; hydroxy; for alkoxy: methoxy or ethoxy; for alkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: alkyl, such as methyl or ethyl, alkylammoalkyl , such as dimethylaminomethyl, or alkanoyl, such as acetyl ; for hydroxyalkyl : hydroxymethyl ; for alkoxyalkyl : methoxymethyl ; for alkoxycarbonyl : methoxycarbonyl ; for alkylammocarbonyl : methylaminocarbonyl; for alkylamino: methylamino, ethylamino or dimethylamino; for hydroxyalkyl substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: carboxyl or carboxymethyl ; and for aminoalkyl substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: amido (CONH 2 ) or amidomethyl . Examples of particular values for Rij are: hydrogen; hydroxy; for alkoxy: methoxy or ethoxy; for alkyl optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: alkyl, such as methyl or ethyl, or alkanoyl, such as acetyl; for hydroxyalkyl : hydroxymethyl ; for alkoxyalkyl : methoxymethyl ; for alkoxycarbonyl : methoxycarbonyl ; for alkylamino: methylamino, ethylamino or dimethylamino; for hydroxyalkyl substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: carboxyl or carboxymethyl; and for aminoalkyl substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl: amido (CONH2) or amidomethyl . More preferably R 2 represents: (i) phenyl optionally being substituted in the 3 and/or 4 position by fluoro, chloro, bromo, iodo, nitro, difluoromethoxy, trifluoromethoxy, amino, cyano, trifluoromethyl, methylthio, vinyl, carboxy, acetoxy, MeSθ 2 -, hydroxy, methoxy, ethoxy, methyl, aminomethyl, methoxycarbonyl, methylamino, ethylamino or amido, and optionally substituted at the 6 position by amino, hydroxy, fluoro, methoxycarbonyl, cyano or aminomethyl (preferably phenyl substituted in the 4 position by chloro, amino, vinyl, methylamino, methyl or methoxy, optionally at the 3 position with amino or hydroxy, and optionally at the 6 position with amino or hydroxy) ; (ii) naphth-2-yl optionally substituted at the 6, position by hydroxy and optionally substituted at the 3 position by amino or hydroxy; (iii) isoquinolin-7-yl, indol-5-yl, indol-6-yl, indazol-5-yl, indazol-6-yl , benzothiazol-6-yl or benzisoxazol-5-yl optionally substituted at the 3 position by chloro, bromo, amino, methyl or methoxy (preferably indol-6-yl optionally substituted at the 3 position by chloro, bromo, methyl or methoxy) ; (iv) benzimidazol-5-yl or benzothiazol-6-yl optionally substituted at the 2 position by amino; (v) thien-2-yl or thien-3-yl optionally substituted at the 4 or 5 position by methylthio, methyl or acetyl; (vi) 3,4-methylenedioxyphenyl, 2, 3 -dihydroindol-6-yl, 3 , 3-dichloro-2-oxo-indol-6-yl or l-methyl-3-aminoindazol-5- yi; (vii) benzothiazol-2-yl, imidazo [1, 2-a] pyrimidin-2-yl or tetrahydroimidazo [1, 2-a] pyrimidin-2-yl ; (viii) pyrazol-2-yl substituted at the 5 position by methyl; (ix) pyrid-2-yl optionally substituted at the 6 position by chloro; (x) pyrid-3-yl optionally substituted at the 4 position by chloro; (xi) benzofur-2-yl optionally substituted at the 3 position by chloro, methyl or methoxy, at the 5 or 6 position by methyl and at the 6 position by methoxy; (xii) indol-2-yl optionally substituted on the indole nitrogen atom by methyl and optionally substituted at the 5 or 6 position by fluoro, chloro, bromo, methyl or methoxy; (xiii) indol-6-yl substituted at the 5 position by chloro, fluoro or hydroxy and optionally substituted at the 3 position by chloro or methyl; or (xiv) benzo [b] thiophen-2-yl optionally substituted at the 3 position by fluoro, chloro or methyl, and optionally substituted at the 5 or 6 position by fluoro, chloro, methyl, hydroxy, or methoxy. Examples of particular values for R 2 are: (i) phenyl, 2-aminophenyl, 3-aminophenyl , 2-amino-3- fluorophenyl, 2 -amino-4-fluorophenyl , 2-amino-4- chlorophenyl, 2-amino-3-bromophenyl, 2-amino-3-nitrophenyl, 2 -amino-4 -nitrophenyl, 3 , 4-dimethoxy-5-aminophenyl , 2-amino- 4-methylphenyl, 2-amino-3-methylphenyl, 2-amino-3- methoxyphenyl , 3 , 4-diaminophenyl , 3 , 5-diaminophenyl, 3- amino-4-fluorophenyl, 3 -amino-4-chlorophenyl , 3-amino-4- bromophenyl, 3 -amino-4-hydroxyphenyl, 3 -amino-4 - carboxymethylphenyl , 3 -amino-4-methylphenyl, 3-amino-4- methoxyphenyl , 2 -fluorophenyl, 4-fluoro-3-cyanophenyl, 3- chlorophenyl , 3-chloro-4-hydroxphenyl, 3-chloro-5- hydroxyphenyl , 4-chlorophenyl, 4 -chloro-2 -hydroxyphenyl , 4- chloro-3 -hydroxyphenyl, 4-chloro-3 -methylphenyl , 4-chloro-3- methoxyphenyl, 4-bromophenyl, 4-bromo-3 -methylphenyl, 4- iodopheny1 , 2-cyanopheny1 , 3 -cyanopheny1 , 4-cyanopheny1 , 3 - cyano-5-aminophenyl, 2-hydroxphenyl, 2-hydroxy-4- methoxyphenyl , 3-hydroxphenyl, 3 -hydroxy-4 -methylphenyl, 2 , 4-dihydroxyphenyl, 3 , 4-dihydroxyphenyl , 3 -hydroxy-4- methoxyphenyl, 4-difluoromethoxyphenyl, 4- trifluoromethoxphenyl , 4-trifluoromethylphenyl , 4- methylthiophenyl, 4-methoxycarbonylphenyl , 4-acetoxyphenyl, 4-methanesulfonylphenyl, 3 -methylphenyl, 3- aminomethylphenyl , 3-aminomethyl-6-aminophenyl, 3-methyl-5- aminophenyl, 4-methylphenyl , 4-vinylphenyl, 4-methoxyphenyl , 4-ethoxyphenyl, 4 -methoxy-3 -chlorophenyl, 4-methoxy-3- methylphenyl, 3-methylaminophenyl, 4-methylaminophenyl, 4- ethylaminophenyl or 2-aminomethylphenyl; (ii) naphth-2-yl, 3-aminonaphth-2-yl , 3-hydroxynaphth- 2-yl or 6-hydroxynaphth-2-yl ; (iii) isoquinolin-7-yl, indol-5-yl, indol-6-yl, 3- chloroindol-6-yl, 3-bromoindol-6-yl, 3 -methylindol-6-yl , 3- methoxyindol-6-yl, indazol-5-yl, 3-aminoindazol-5-yl , indazol-6-yl, benzothiazol-6-yl, 3-aminobenzisoxazol-5-yl; (iv) benzimidazol-5-yl , 2-aminobenzimidazol-5-yl, or benzothiazol-6-yl ; (v) thien-2-yl, 5-methylthien-2-yl, 5-methylthio-thien- 2-yl, 5-acetylthien-2-yl or thien-3-yl; (vi) 3 , 4-methylenedioxyphenyl, 2 , 3 -dihydroindol-6-yl, 3, 3-dichloro-2-oxo-indol-6-yl or l-methyl-3-aminoindazol-5- yi; (vii) benzothiazol-2-yl, imidazo [1, 2-a] pyrimidin-2-yl or tetrahydroimidazo [1, 2-a] pyrimidin-2-yl; (viii) 5-methylpyrazol-2-yl; (ix) 5-chloropyrid-2-yl; (x) pyrid-3-yl, 6-chloropyrid-3-yl ; (xi) benzofur-2-yl, 5-chlorobenzofur-2-yl, 3- methylbenzofur-2-yl, 5-methylbenzofur-2-yl, 6- methoxybenzofur-2-yl; (xii) indol-2-yl, 5-fluoroindol-2-yl , 5-chloroindol-2- yl, 5-methylindol-2-yl, 5-methoxindol-2-yl, 6-methoxyindol- 2-yl and 1-methyl-indol-2-yl ; (xiii) 5-fluoroindol-6-yl; or (xiv) benzo [b] thiophen-2-yl, 5-chloro- benzo [b] thiophen-2-yl or 6-chlorobenzo [b] thiophen-2-yl . It has been found that in compounds of formula (I) that have been found to be tryptase inhibitors, the aromatic R 2 group is of the formula in which R 5 is amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen, and R 6a is hydrogen or methyl. For a tryptase inhibitor, preferably R 2 is 3- aminomethylphenyl or 3 -aminomethyl- 6 -aminophenyl . Most preferably it is 3-aminomethylphenyl . In one embodiment the aromatic R2 group is an optionally substituted phenyl, naphthyl, indolyl or isoindolyl group and accordingly, preferred compounds of formula (I) are of formula (II) (ID wherein R5 is amino, hydroxy or hydrogen, and Rg and R which may be the same or different represent halo, nitro, thiol, cyano, haloalkyl, haloalkoxy, amido, hydrazido, amino, alkylthio, alkenyl, alkynyl or Ri or taken together form a 5 or 6 membered fused carbocyclic ring or 5 membered heterocyclic ring, which may itself be substituted by Rij, amino, halo, cyano, nitro, thiol, alkylthio, haloalkyl, haloalkoxy; Ar is an unsubstituted or substituted aryl group, preferably phenyl; X-X is -CONH-, -CH 2 CH 2 -, CH 2 0-, -COO-, -CH 2 NH-, -OCH 2 - or -NHCH2-, especially -CONH-; Li is a valence bond or an organic linker group containing 1 to 4 backbone atoms selected from C, N, 0 and S; Lpi is a cycloalkyl, azacycloalkyl, diazacycloalkyl, phenyl, naphthyl, adamantyl, decalinyl, bicycloalkyl, mono- or diazabicycloalkyl, mono- or bicyclo heteroaromatic or a linear or branched alkyl, alkylene, alkenyl or alkenylene group all optionally substituted by a group R 3 , or a combination of at least two such groups linked by a spiro linkage or a single or double bond or by C=0, 0, S, SO, SO2 , C0NRι e , NRι e -CO-, NR e linkage (for example, representative lipophilic groups include a methyl-cyclohexyl, methylcyclohexylmethyl, bispiperidinyl, methylphenylmethyl, phenylethyl, benzylpiperidinyl, benzoylpiperidinyl or phenylpiperazinyl and those as hereinbefore described) ; D is a hydrogen bond donor group; and n is 0, 1 or 2. Suitable R 2 groups may be wherein R 5 is hydrogen, amino or hydroxy and R 3 (in relation to R 2 ) is halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij. In a particularly favoured embodiment the R 2 group is an indole as marked by a * above in which R 5 is hydrogen and R 3 is a hydrogen or halogen present at the 3 position. It is preferred that at least one of Rg and R 7 be other than hydrogen and that Rg, if present, is preferably a substituent containing one or more polar hydrogens such as hydroxy, amino, alkylamino, aminoalkyl, alkylammoalkyl , aminocarbonyl, alkylammocarbonyl , hydrazo and aIky1hydrazo; alternatively Rg and R 7 are joined together in the formation of a naphthyl or indolyl or azaindolyl or diazaindolyl group . It is especially preferred that Rg be amino and R 7 be chloro, bromo, methyl, methoxy or vinyl; or that Rg and R 7 taken together form an indolyl ring with the NH at the 6- position or taken together form a naphthyl ring. In a further preferred embodiment the compounds of formula (I) are of formula (A) (wherein R 5 , Rg, R 7 , Ar, X-X, Lpi, D n are as hereinbefore defined; L2 is a valence bond or an organic linker group containing 1 to 3 backbone atoms selected from C, N, O and S and Rg a an( Rg a are hydrogen or taken together with the carbon atom to which they are attached form a carbonyl group) . Again, in an alternative embodiment the phenyl derivative forming part of the R 2 functionality may instead be a nitrogen heterocyclic group, e.g. pyridine. In one embodiment, L2 comprises the backbone of an alpha amino acid, the lipophilic group being the side chain of the amino acid. In one preferred embodiment Rg a and Rg a are hydrogen and L is a OC=0 or NHC=0 group. In a preferred embodiment, L 2 represents a valence bond and the lipophilic group is bound directly to a carbonyl alpha to the alpha atom via a nitrogen atom which forms part of the lipophilic group. Suitable lipophilic groups in this case therefore include piperidinyl, pyrrolidinyl and piperazinyl . In a preferred embodiment the piperidine or piperazinyl group is further substituted by a phenyl, benzyl, phenoxy, piperidine, pyridine or benzoyl group, optionally substituted on the phenyl ring by one or more R 3 groups. In a more preferred embodiment a piperazine is substituted with a phenyl group substituted at the 2- position with an electron withdrawing group such as fluoro, nitro, triazolyl, cyano, alkoxycarbonyl, aminocarbonyl, aminosulphonyl, alkylaminosulphonyl and, especially preferred, alkylsulphonyl; and, at the 4-position, with hydrogen, fluoro, alkoxy or hydroxy. In another more preferred embodiment a piperidine is substituted at the 4- position with 4-piperidine which itself may be substituted on nitrogen by alkyl or aminocarbonylalkyl or alkylammocarbonyl alkyl . In a further embodiment, the lipophilic group has attached a group of the formula -COORig or -CON-aminoacid or ester derivative thereof (where Rig is as defined for Rι a ) . Particularly preferred compounds are those of formula (G) (G) (wherein Ar, Rg and R 7 are as hereinbefore defined, R5 represents hydrogen or amino and represents a cyclic group) o or of formula (H) (H) (wherein Rg and R7 are as hereinbefore defined, and R5 represents hydrogen or amino) . In a preferred embodiment Rg is amino and R7 a halogen, especially chlorine. Again, in an alternative embodiment the phenyl derivative forming part of the R2 functionality in formulae (G) and (H) may instead be a nitrogen heterocyclic group, e.g. pyridine, indole. In another embodiment the group binding the alpha carbon atom to the lipophilic group comprises a heterocyclic group. Accordingly, preferred compounds of formula (I) also include those of formula (III) (III) (wherein R5, Rg, R7, Ar, X-X, Lp , D n are as hereinbefore defined; m is 0, 1 or 2 ; Het is a 5 or 6-membered heterocyclic group interrupted by 1, 2 or 3 heteroatoms selected from 0, N and S optionally substituted by a group R 3 b where R 3 b is as defined for R 3 ) . Again, in an alternative embodiment the phenyl derivative forming part of the R 2 functionality may instead be a nitrogen heterocyclic group, e.g. pyridine. Where Het is a five membered ring, the two ring atoms at which it is connected are preferably separated by one ring atom. Where Het is a six-membered ring, the two ring atoms at which it is connected are preferably separated by one or two ring atoms. Representative heterocyclic groups include thiazole, oxazole, oxadiazole, triazole, thiadiazole or imidazole. Where the heterocyclic group is substituted by R 3 k this is preferably a COOH or COORig connected to the heterocycle via a valence bond or alkylene chain (where Rih is as defined for Rι a ) . In a further embodiment, the lipophilic group has attached a group of the formula -COORig or -CON-aminoacid or ester derivative thereof. In an alternative embodiment, the main aromatic R 2 ring in the compounds of the invention is a five membered aromatic ring leading to compounds of formula (IV) or (IVa) (wherein R5 , Rg , R7 , X-X, Ar, Li, Lpi, D and n are as hereinbefore described for formula (II) and Z represents N, 0 or S) . It is preferred that at least one of Rg and R7 be other than hydrogen, or that Rg and R7 taken together enable the formation of an indolyl, or azaindolyl group or diazaindolyl group. Preferences for other substituents are as for formula (A) above. Examples of possible fused systems are given below. Hence in a preferred embodiment the compounds of the invention are of formula C or D (wherein R5, Rg, R7, Ar, X-X, Z, Rg , Rg, L2 Lpi, D n are as hereinbefore defined) preferences for Ar, X-X, Rg a , 9 a. L 2' Lp , D n are as for formula (A) above; or compounds of formula E or F: wherein Lpi is connected to the carbonyl via a nitrogen atom, Rg, R 7 , Ar, Z, Lpi, D n are as hereinbefore defined and R5 is hydrogen or amino) preferences for Ar, Lpi, D n are as for formula (A) above. Particularly preferred compounds of formula (I) for use as Factor Xa inhibitors are the compounds of Examples 35, 63, 66, 73, 100, 318 and 320, and physiologically tolerable salts thereof. As previously mentioned, a number of compounds of formula (I) have been found to be excellent mixed inhibitors in that they inhibit both the serine proteases Factor Xa and thrombin. Such mixed inhibitors are preferably based on the formula (L) (L) wherein R' represents X 3 represents hydrogen or a polar group such as amino or CONH 2 , especially CONH ; and R" represents a cyclic group bound to the carbonyl by a nitrogen atom or an optionally substituted group of formula A group of compounds of particular interest for use as tryptase inhibitors is that of formula in which: L-Lp(D) n represents CO-L x ; R 5 represents amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen; R 6a represents hydrogen or methyl; Cy is a saturated or unsaturated, mono or poly cyclic, • homo or heterocyclic group, preferably containing 5 to 10 ring atoms and optionally substituted by groups R 3a or phenyl optionally substituted by R 3a ; each R 3a independently is R lc , amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl , alkylsulphenyl, hydrazido, alkylsulphonamido, alkylamino-sulphonyl, aminosulphonyl, haloalkoxy, and haloalkyl; each R lc independently represents hydrogen or hydroxyl, alkoxy, alkyl, aminoalkyl, hydroxyalkyl alkoxyalkyl, alkoxycarbonyl , acyloxymethoxycarbonyl or alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl; L x is a mono or bicyclic group bound to the carbonyl via a pendent nitrogen atom or nitrogen atom which forms part of the mono or bicyclic ring; or a physiologically tolerable salt thereof, e.g. a halide, phosphate or sulphate salt or a salt with ammonium or an organic amine such as ethylamine or meglumine . It will be appreciated that when L x is bound to the carbonyl via a pendant nitrogen, the group CO-L x corresponds with the group L-Lp(D) n in which L is CONH and Lp is a mono or bicyclic group. When Lx is bound to the carbonyl via a nitrogen that forms part of the mono or bicyclic ring, the group CO-Lx corresponds with the group L-Lp(D) n in which L is CO and Lp is a mono or bicyclic group containing a nitrogen atom in the ring and bound to L via this nitrogen. It is believed that an aminomethyl group positioned on the 3 position of the phenyl ring will give rise to excellent binding within the SI binding pocket of tryptase. Without wishing to be limited by theory it is believed that the presence of a hydrogen bond donating group attached to the phenyl group will be essential for successful inhibition of tryptase. R 5 and R 6 are both preferably hydrogen. Most preferably the Lx group comprises wherein : A and B are independently chosen from NH, N, 0, S, CH, CH 2 ; X lx and X 2x are independently chosen from (CH 2 ) ra , (CH 2 ) m CH=CH(CH 2 ) p , CO(CH 2 ) m , NH(CH 2 ) ra , NHCO(CH 2 ) m , CONH(CH 2 ) m , S0 2 NH(CH 2 ) m ,NHS0 2 (CH 2 ) m ; n is 1 or 2 m is 0 to 2 p is 0 to 2 R lx and R 2x are independently chosen from hydrogen, alkoxy, alkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl, alkylsulphenyl, oxo, heterocyclo optionally substituted by R 3x , cycloalkyl optionally substituted by R 3x or aryl optionally substituted by R 3x ; and R 3x is hydrogen, alkoxy, alkyl, amino, hydroxy, alkoxy, alkoxycarbonyl, halo, cyano, nitro, thiol, sulphonyl, or sulphenyl . Examples of heterocyclic R lx and R 2x groups are piperidine, piperazine and pyrrolidine. The cyclic group attached to the alpha atom is preferably an optionally R 3a substituted phenyl. Thus, one group compounds of formula (I) of interest as tryptase inhibitors are those of formula (II) * the alpha atom II wherein Lx is as hereinbefore defined. It is envisaged that especially preferred Lx groups will be those in which a cyclic or bicyclic ring is substituted by hydrogen bond donating and/or acceptor groups. The compounds of formula (I) may be prepared by conventional chemical synthetic routes or by routes as illustrated by the following examples, e.g. by amide bond formation to couple the aromatic function to the alpha atom and to couple the lipophilic function to the alpha atom. Where the alpha atom is a carbon, the cyclic group-alpha atom combination may conveniently derive from an alpha amino acid with the aromatic deriving from for example an acid derivative of a compound based on R2 , e.g. o-amino-benzoic acid or aminomethylbenzoic acid. Amide formation from such reagents (in which any amino or hydroxyl function (especially in an aminomethyl group) may if desired be protected during some or all of the synthesis steps) yields a compound of formula (V) . R 2 - CONH - CH ( Cy) - COOH (V) (where Cy and R2 are as defined above) . Prior to reaction the amino group in an aminoalkyl group should be protected by an appropriate protecting group e.g. Boc, Z, Fmoc or Bpoc . The use of protecting groups is described in McOmie, "Protective Groups in Organic Chemistry", Plenum, 1973 and Greene, "Protective Groups in Organic Synthesis", Wiley Interscience, 1981. The lipophilic group (and optionally simultaneously the hydrogen bond donor) may then conveniently be introduced by reaction of a compound of formula (V) (or another analogous carboxylic acid) optionally after transformation into an activated form, e.g. an acid chloride or active ester, with a lipophilic group carrying an amine, hydroxylamine, hydrazine or hydroxyl group, e.g. to produce compounds with linkages of -CO-NR^-, -CO-NRi^-O- , -CO-NR^-NR^- and -CO-O- from the alpha atom (where it is a carbon) to the lipophilic group. Cyclisation can be base induced via nucleophilic attack of the alpha atom on a leaving group on the active side chain. If necessary the amide linkage can be reduced using an appropriate reducing agent employing the necessary protection depending on whether concurrent reduction of the carboxylic acid moiety is also desired. Alternatively a compound of formula V or another analogous carboxylic acid may be transformed into an alcohol by reaction with isobutylchloroformate and reduction with sodium borohydride . Such an alcohol, e.g. of formula VI R 2 - CONH - CH(Cy)CH 2 OH (VI) can be reacted to introduce the lipophilic group by reactions such as: alkylation with an alkyl halide in the presence of a base ; under Mitsunobu conditions, such as reaction with diethyl azodicarboxylate/triphenylphosphine and a hydroxylated aryl compound; by reaction with an activated carboxylic acid (e.g. an acid chloride) or with a carboxylic acid and diethylazodicarboxylate/triphenylphosphine; by reaction with an isocyanate; and by treatment with methanesulphonyl chloride or trifluoromethanesulphonic anhydride and reaction with an amine, or with a thiol optionally followed by oxidation, e.g. with potassium metaperiodate or hydrogen peroxide. Alternatively, the reactions described above may be performed on a corresponding compound of formula (VI) in which R 2 is replaced with a protecting group, such as t- butoxycarbonyl (Boc) , followed by deprotection and introduction of the group R 2 . In this way compounds with linkages of -CH2-0-, -CH 2 -0-C0-, -CH 2 -0-CO-NRι d -, -CH 2 -NRι d -, -CH 2 -S-, -CH 2 -SO- and -CH 2 -SO 2 - between the alpha carbon and the lipophilic group may be produced. Alternatively the alcohol can be oxidized to form a corresponding aldehyde (e.g. by oxidation with manganese dioxide or DMSO/oxalyl chloride or DMSO/SO 3 or Dess-Martin reagent) which may be reacted to introduce the lipophilic group by reactions such as: reaction with Wittig reagents or Horner-Emmons reagents, optionally followed by reduction of the resulting carbon: carbon double bond using H 2 /Pd-carbon; reaction with an organometallic, eg a Grignard reagent, optionally followed by reaction on the resulting hydroxyl group, such as oxidation (eg with Mnθ 2 , DMSO/oxalyl chloride or Dess-Martin reagent) , alkylation (eg with an alkyl halide in the presence of a base in a solvent such as DMF) , arylation (eg with diethylazo dicarboxylate/triphenyl phosphine and a hydroxyaryl compound) , ester formation (eg with an acid chloride or with a carboxylic acid and diethylazido dicarboxylate/triphenyl phosphine) , or carbamate formation (eg with an isocyanate) ; by reaction with an amine followed by reduction, e.g. with sodium cyanoborohydride; by reaction with a hydrazine; or by reaction with a carbazide. In this way compounds with linkages of -CH=CRι d -, -CH 2 -CHRι d -, -CHOH-, -CHRι d -0-, -CHR 1( j-0-CO- , -CHRι d -0-CO-NR ld -, -CO-, -CH 2 -NRι d -, -CH=N-NRι d - and -CH=N-NRι d -CO-NRι d - between the alpha carbon and the lipophilic group may be produced. The transformation of alcohol to amine referred to above may be used to produce an amine reagent for lipophilic group introduction, e.g. a compound R 2 -CONH-CH(Cy) -CH 2 -NRι d H. Such an amine reagent may be reacted to introduce the lipophilic group, e.g. by acylation with an acid halide or activated ester, by reaction with isocyanate, by reaction with an isothiocyanate, or by reaction with a sulphonyl chloride. In this way compounds with linkages of -CH 2 NRι d - CO-, -CH 2 -NRι d -CO-NRι-, -CH 2 NRι d -CS-NR ld - and -CH 2 NRι d -S0 2 - between the alpha carbon and the lipophilic groups may be produced. The transformation of acid to amide referred to above may be used to produce an amide reagent for introduction of the lipophilic group, e.g. a compound R 2 -CONH-CH(Cy) -CON(R ld ) 2 - Such amides may be reacted to introduce lipophilic groups, e.g. by reaction with a haloketone (e.g. phenacyl bromide) . This provides a linkage from alpha carbon to lipophilic group. Analogously the amide may be transformed to a thioamide by reaction with Lawesson's reagent and then reacted with a haloketone to form a linkage The amide reagent may likewise be transformed to a nitrile reagent by dehydration, e.g. with trifluoroacetic anhydride. The nitrile reagent may be reacted with hydrazine then with acyl halide and then cyclized, (e.g. with trifluoroacetic anhydride) to produce a linkage Alternatively it may be treated with hydroxylamine then reacted with acyl halide and cyclized (e.g. with trifluoroacetic anhydride) to produce a linkage The hydrazide produced by reaction of a carboxylic acid reagent with hydrazine discussed above may likewise be used as a reagent for lipophilic group introduction, e.g. as a compound of formula R 2 -CONH-CH(Cy) -CO-NRι~N (R id ) 2 • Thus the hydrazide reagent can be reacted with an acyl halide and cyclized, e.g. with trifluoroacetic anhydride to yield a linkage or reacted with an acyl halide or an isocyanate to yield linkages -CO-NRι d -NRι d -CO- and -CO-NRι d -NRι d -CO-NRι d - respectively. Alternatively the hydrazide may be transformed by reaction with Lawesson's reagent and then reacted with an acyl halide and cyclized (e.g. with trifluoroacetic anhydride) to produce the linkage An alternative route to these compounds is to carry out any of the above chemical reactions to incorporate the lipophilic group (and optional H bond donor) into a protected intermediate such as a compound of formula (VII) . PG = Protecting group The protecting group may then be removed before coupling of the for example o-amino benzoic acid (optionally protected) . The protection of amino and carboxylic acid groups is described in McOmie, Protecting Groups in Organic Chemistry, Plenum Press, NY, 1973, and Greene and Wuts, Protecting Groups in Organic Synthesis, 2nd. Ed., John Wiley & Sons, NY, 1991. Examples of carboxy protecting groups include C x - C 6 alkyl groups such as methyl, ethyl, t-butyl and t-amyl; aryl (C 1 -C 4 ) alkyl groups such as benzyl, 4-nitrobenzyl, 4- methoxybenzyl , 3 , 4-dimethoxybenzyl, 2 , 4-dimethoxybenzyl , 2 , 4, 6-trimethoxybenzyl, 2 , 4 , 6-trimethylbenzyl , benzhydryl and trityl; silyl groups such as trimethylsilyl and t- butyldimethylsilyl; and allyl groups such as allyl and 1- (trimethylsilylmethyl)prop-l-en-3-yl . Examples of amine protecting groups (PG) include acyl groups, such as groups of formula RCO in which R represents C- L - s alkyl, C 3 - 10 cycloalkyl, phenyl C _ 6 alkyl, phenyl, C^ alkoxy, phenyl alkoxy, or a C 3 - 10 cycloalkoxy, wherein a phenyl group may be optionally substituted, for example by one or two of halogen, C^d alkyl and C- . -C,, alkoxy. Preferred amino protecting groups include benzyloxycarbonyl (CBz) , t-butoxycarbonyl (Boc) and benzyl. α-Amino acids of formula (VII) which are not commercially available can be synthesized by methods known in the art, for example as described in "Synthesis of Optically Active α-Amino Acids" by Robert M. Williams (Pergamon Press, 1989) and "Asymmetric Synthesis of ArylGlycines" , Chem. Rev. 1992, 889-917. Compounds of the type (VII) made be prepared (for example) by one or more of the following methods. (i) from aryl or heteroaryl aldehydes via the Strecker synthesis or modifications thereof, via Bucherer-Bergs hydantoin synthesis, or via the Ugi methodology (Isonitrile Chemistry, Ugi I. Ed.; Academic: New York, 1971; ppl45-199) with removal and replacement of protecting groups; (ii) from styrenes via Sharpless methodology (J. Am. Chem. Soc. 1998,120, 1207-1217) (iii) from aryl boronic acids via Petasis methodology (Tetrahedron, 1997, 53, 16463-16470) with removal and replacement of protecting groups; (iv) from aryl and heteroaryl acetic acids - via Evan's azidation (Synthesis, 1997, 536-540) or by oximation, followed by reduction and addition of protecting groups; or (v) from existing aryl glycines by manipulation of functional groups, for example, alkylation of hydroxy groups, palladium assisted carbonylation of triflates derived from hydroxy groups and further manipulation of the carboxylic esters to give carboxylic acids by hydrolysis, carboxamides by activation of the carboxylic acid and coupling with amines, amines via Curtius reaction on the carboxylic acid or (vi) from aliphatic, carbocylic and non-aromatic heterocyclic aldehydes and ketones using a Horner-Emmons reaction with N-benzyloxycarbonyl) -α-phosphonoglycine trimethyl ester (Synthesis, 1992, 487-490) . Examples of synthetic routes are shown below: ) 2 EDC, DMAP MeOH ZCI, NEt3 THF Synthesis of protected 4-piperidylglycine Synthesis of protected 2-aminothiaz-4-ylglycine 0 A starting reagent for lipophilic group introduction where the alpha atom is nitrogen may be produced for example by reaction of a beta protected hydrazine (such protection to be chosen as to be compatible with the subsequent reagents to be employed) with phosgene, diphosgene, triphosgene or N,N' carbonyl diimidazole to give a reactive compound of the type : or imidazole PG = Protecting group This intermediate may be used as has been described above for the carboxylic starting reagents where the alpha atom is carbon . Removal of the protecting group by standard methods and coupling with an activated aryl carboxylic acid will give compounds of the type R 2 -C0NH-N(Cy) -L-Lp(D) n (where R2, X, Y, Cy, L, Lp and D are as defined above) . Thus the compounds of formula (I) may be prepared by a process which comprises coupling a lipophilic group to a compound of formula (VIII) R 2 -(X) 2 -Y(Cy) -Zi (VIII) (wherein R2 , X, Y and Cy are as defined above and Zi is a reactive functional group) , and optionally subsequently coupling a hydrogen bond donor group to said lipophilic group . Instead of introducing the group L-Lp(D) n as the final stage process step, the compounds of formula I may alternatively be prepared by a process in which the group R 2 is introduced in the final process step. Thus the compounds of formula (I) may also be prepared by a process which comprises coupling a lipophilic group to a compound of formula (IX) Z 2 -Y(Cy) -L-Lp(D) n (IX) (wherein Y, Cy, L, Lp D, and n are as defined above and Z 2 is HX or a reactive functional group) , or a protected derivative thereof, with a compound of formula (X) R 2 - Z 3 (wherein R 2 is as defined above and Z 3 is XH or an appropriate reactive group) , or a protected derivative thereof, followed if necessary by the removal of any protecting groups. Thus, for a compound of formula I in which X-X represents CONH, a compound of formula (IX) in which Z2 is H 2 N may be reacted with a compounds of formula (X) in which Z 3 is COOH or a reactive derivative thereof, such as a acyl halide or an anhydride, for example as described in the Examples herein. Where the lipophilic group Lp comprises more than one group, it may generally be formed by coupling these groups together at an appropriate stage in the preparation of the compound of formula I using conventional methods or as descibed in the Examples. For a compound of formula I in which Lp comprises an azacycloalkyl or diazacycloalkyl group of formula in which X^ is N and each of s and u is 0, alkylating the amino group of a corresponding compound in which the corresponding residue is of formula using a conventional alkylating method. The alkylation may be carried out using any conventional method; however, generally preferred is a reductive alkylation using the appropriate aldehyde or ketone, for example as described in the Alkylation Methods in the Examples . Thus, a particular starting material for the alkylation is one of formula R 2 -CO-NH-C(Cy)-L X a Λ NH in which X a is N and L is CO or X a is CH and L is CONH, CONHCH 2 or CH 2 NHCO. For a compound of formula I in which Lp comprises an azacycloalkyl or diazacycloalkyl group of formula " Xa X b (L a )s-(G)r(L b )-Rio in which RI Q is a group of formula in which X d is N and Rn is (1-6C) alkyl, alkylating the amino group of a corresponding compound of formula I in which Rii is hydrogen using a conventional method. Generally preferred is a reductive alkylation using the appropriate aldehyde or ketone, for example as described in the Alkylation Methods in the Examples. For a compound of formula I in which Lp comprises an azacycloalkyl or diazacycloalkyl group of formula in which Xj-> is CH and (L a ) s - (G) t - (L b ) u is O and R 10 is phenyl or pyridyl, coupling a corresponding compound containing a group of formula with phenols or 3-hydroxypyridine using Mitsunobu conditions, eg. DEAD (diethyl azodicarboxylate) /Ph 3 P or 2- triphenylphosphonium 4 , 4 -dimethyl -tetrahydro-1, 2,5- thiadiazole to give aryloxy or 3-pyridoxy substituted piperidines or pyrrolidine. Alternatively the hydroxy group may be reacted with sodium hydride and 2 -chloro or 4- chloropyridine to give 2-pyridoxy or 4-pyridoxy substituted piperidines or pyrrolidines . For a compound of formula I in which -L-Lp(D) n is in which Q is a direct bond, reductively alkylating an amine of formula H-Q using a corresponding compound in which the corresponding residue is a ketone of formula For a compound of formula I in which -L-Lp(D) n is in which Q is methylene, reductively alkylating an amine of formula H-NR^]-, using a corresponding compound in which the corresponding residue is an aldehyde of formula For example, methyl l-acetyl-3-formylindole-6- carboxylic acid may be converted to the 3 -formate by the method of Merour et al (Synthesis, 1994, 411) and then reacted with trimethyl orthoformate to give methyl 1-acetyl- 3-methoxyindole-6-carboxylate which is then hydrolysed to methyl 1-acetyl-3 -methoxyindole-6-carboxylate . 5-Fluoroindole-6-carboxylic acid may be prepared from 4-fluoro-3-methoxyaniline by the following method. 4-Fluoro- 3-methoxyaniline is treated with glyoxal-1, 1-dimethyl acetal and then hydrogenated over Pd/C. The product is N-protected with methanesulphonyl chloride and then cyclised using titanium tetrachloride in toluene. Demethylation with BBr 3 to the phenol followed by reaction with triflic anhydride and then palladium carbonylation in methanol gives the methyl ester, which is then converted to 5-fluoro-l- methanesulphonylindole-6-carboxylic acid by hydrolysis with lithium hydroxide. This 'benzoyl' component may be reacted as previously described and deprotected by hydrolysis with sodium hydroxide at 100°C. The compounds of formula (I) may be administered by any convenient route, e.g. into the gastrointestinal tract (e.g. rectally or orally) , the nose, lungs, musculature or vasculature or transdermally. The compounds may be administered in any convenient administrative form, e.g. tablets, powders, capsules, solutions, dispersions, suspensions, syrups, sprays, suppositories, gels, emulsions, patches etc. Such compositions may contain components conventional in pharmaceutical preparations, e.g. diluents, carriers, pH modifiers, sweeteners, bulking agents, and further active agents. Preferably the compositions will be sterile and in a solution or suspension form suitable for injection or infusion. Such compositions form a further aspect of the invention. The following are examples of pharmaceutical compositions of compounds of formula (I) or physiologically tolerable salts thereof. Formulation 1 Hard gelatin capsules are prepared using the following ingredients : Quantity (mg/capsule) Active Ingredient 250 Starch, dried 200 Magnesium stearate 10 Total 460 mg The above ingredients are mixed and filled into hard gelatin capsules in 460 mg quantities. Formulation 2 Tablets each containing 60 mg of active ingredient are made as follows: Active Ingredient 60 mg Starch 45 mg Microcrystalline cellulose 35 mg Polyvmylpyrrolidone 4 mg Sodium carboxymethyl starch 4.5 mg Magnesium stearate 0.5 mg Talc 1 mg Total 150 mg The active ingredient, starch, and cellulose are passed through a No. 45 mesh U.S. sieve and mixed thoroughly. The solution of polyvmylpyrrolidone is mixed with the resultant powders which are then passed through a No. 14 mesh U.S. sieve. The granules so produced are dried at 50°C and passed through a No. 18 mesh U.S. sieve. The sodium carboxymethyl starch, magnesium stearate, and talc, previously passed through a No. 60 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 150 mg. It is believed that the compounds of the invention will have excellent oral bioavailability. Thus the compounds of formula (I) and their physiologically tolerable salts will generally be adminstered to a patient in pharmaceutical composition which comprises a serine protease inhibitor of formula (I) together with at least one pharmaceutically acceptable carrier or excipient. The pharmaceutical composition may also optionally comprise at least one further antithrombotic and/or thrombolytic agent. The dosage of the inhibitor compound of formula (I) will depend upon the nature and severity of the condition being treated, the administration route and the size and species of the patient. However in general, quantities of from 0.01 to 100 μmol/kg bodyweight will be administered. All publications referred to herein are hereby incorporated by reference. The following non-limiting Examples illustrate the preparation of compounds of formula (I) for use as serine protease inhibitors according to the invention. Examples - Part 1 Experimental Abbreviations used follow IUPAC-IUB nomenclature. Additional abbreviations are Hplc, high-performance liquid chromatography; DMF, dimethylformamide; DCM, dichloromethane; HAOT, 1-hydroxy-7-azabenzotriazole; HATU, [0- (7-azabenzotriazol-l-yl) -1,1,3, 3-tetramethyluronium hexafluorophosphate] ; Fmoc, 9-Fluorenylmethoxycarbonyl; HOBt, 1-hydroxybenzotriazole; TBTU, 2- (IH- (benzotriazol-1- yl) -1, 1, 3 , 3-tetramethyluroniumtetrafluoroborate; EDCI, l-(3- Dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride; DIPEA, diisopropylethylamine; Boc, tertiary butyloxycarbonyl ; DIPCI, diisopropylcarbodiimide; DBU, 1,8- diazabicyclo [5.4.0] undec-7-ene; TEA, triethylamine; Rink linker, p- [ (R, S) -α- [1- (9H-Fluoren-9-yl) methoxyformamido] - 2 , 4-dimethoxybenzyl] henyl acetic acid; TFA, trifluoroacetic acid; MALDI-TOF, Matrix assisted laser desorption ionisation - time of flight mass spectrometry, RT, retention time. Amino acid derivatives, resins and coupling reagents were obtained, for example, from Novabiochem (Nottingham, UK) and other solvents and reagents from Rathburn (Walkerburn, UK) or Aldrich (Gillingham, UK) and were used without further purification. All solution concentrations are expressed as %Vol./%Vol. unless otherwise stated. Purification: Purification was by gradient reverse phase Hplc on a Waters Deltaprep 4000 at a flow rate of 50 ml/ min. using a Deltapak C18 radial compression column (40 mm x 210 mm, 10-15 mm particle size) . Eluant A consisted of aqTFA (0.1%) and eluant B 90% MeCN in aq TFA(0.1%) with gradient elution (Gradient 1, 0 min. 20%B then 20% to 100% over 36 min., Gradient 2, 0 min. 5%B for 1 min. then 5%B to 20%B over 4 min., then 20% to 60% over 32 min. or Gradient 3, 0 min. 20%B then 20% to 100% over 15 min.) . Fractions were analysed by analytical Hplc and MALDI-TOF before pooling those with >95% purity for lyophilisation. Analysis: Analytical Hplc was on a Shimadzu LC6 gradient system equipped with an autosampler, a variable wavelength detector at flow rates of 0.4 ml/ min. Eluents A and B as for preparative Hplc. Columns used were Techogell5 C18 (2x150mm) (Hplc Technology), Magellan C8 column (2.1x150 mm, 5μm particle size) and Luna C18 (2.1x150 mm, 5μM particle size) . (Phenomenex) ) Purified products were further analysed by MALDI-TOF and nmr. NMR denotes an HNMR consistent with the structure was obtained. Synthesis of inhibitors Method 1: Using a solid phase strategy on a Protein Technologies, Symphony Multiple Peptide Synthesiser by attachment of bis amino compounds to Peg-trityl chloride resin: Trityl chloride resin was typically treated with greater than 2 fold excess of the di-amine in dry DCM .The resin was further modified by the attachment of acids. Activation of Fmoc protected amino acid (2-5eq) was by TBTU/ DIPEA, all couplings ( minimum 120 min.) were carried out in DMF. Deprotection of the Fmoc group was achieved with 20% piperidine in DMF. In the next stage other acid substituents were added as the HOBt or HOAt esters either by activation with HBTU/HATU or HATU/EDCI with or without Boc protection of amino groups. Cleavage of the products from the resin was by treatment (30 min., ambient) with 10% triethylsilane in TFA, filtration, evaporation and trituration with diethylether. Synthesis using the Symphony Multiple Peptide Synthesiser. The Symphony Multiple Peptide Synthesiser is charged with DMF, DCM, TBTU in DMF(450 mM) , DIPEA in DMF (900 mM) , 20% piperidine in DMF. Resins are held in plastic reaction vessels that allow the introduction of reagents and solvents and nitrogen for agitation or air drying. A typical synthesis cycle on the Symphony is as follows :- The reaction vessel containing the resin (0.1 mmol) is charged with the Fmoc protected amino acid (0.5 mmol) and then this is dissolved in DMF (2.5ml), treated with TBTU (0.56 mmol, 1.25ml) and DIPEA (1.1 mmol, 1.25ml) and agitated with nitrogen for 2 hours (agitation times may vary) . After coupling the resin is washed with DMF (6x 5ml) then deprotected with 20% piperidine in DMF (2x 5ml for 1 min. each, then lx 5ml for 8 min.) the resin is then washed with DMF (6x 5ml) . Example 1. 1- (2-Amino-4-chlorobenzoyl-D-phenylglycinyl) -4,4' - bispiperidine 4,4-Bipiperidine.dihydrochloride (4mmol,lg) was dissolved in water (5ml) and 2M sodium hydroxide solution (lOmmol, 5ml) added. The solution was extracted with ethylacetate (2x 50ml) the combined extracts were washed with water, dried over anhydrous sodium carbonate, filtered and evaporated to give the 4,4 bipiperidine (0.35g) as a white solid. The 4,4 bipiperidine was dissolved in dry DMF (2ml) and added to Peg-tritylchloride resin (0.95 mmol/g, 1.5g) pre swollen in dry DCM (10ml) . After 2h the resin was washed with DCM (6x5ml) , DMF (6x5ml) and DCM (6x5ml) . The resin was then air dried to allow aliquots to be taken. The 4,4 bipiperidine trityl resin (0.1 mmol) was treated with Fmoc-D-Phenylglycine (0.5 mmol, 187mg) , DMF (2.5ml), TBTU in DMF (1.25ml of a 450mM solution) and DIPEA in DMF (1.25ml of a 900 mM solution) . The mixture was agitated with nitrogen for 2 hours. Deprotection and washing as above. A solution of 4-chloroanthranilic acid (87mg 0.5mmole) in dry dimethylformamide (DMF) was treated successively with HOAt (102mg 0.75mmole) and EDCI (115mg 0.6mmole) and stirred at room temperature for lOmin. The mixture was transferred to the reaction vessel on the Symphony and agitated for 2 hours with nitrogen. The resin was washed with DMF (6x5ml) , DCM (6x5ml) and air dried. The product was cleaved from the resin with 10% triethylsilane in TFA (10ml) for 30 minutes, the resin filtered off and the TFA solution evaporated to dryness and triturated with diethyl ether to give the crude product. The crude product was dissolved in water (10ml), filtered and purified by preparative reverse phase Hplc. !H nmr (CD 3 CN) 7.30 (6H,m); 6.60 (lH,s); 6.55 (lH,d); 5.85 (IH, s) ; 4.40 (lH,m); 3.75 (IH, m) ; 2.30-2.95 (6H, m) ; 1.60 (4H, m) ; 1.10 (6H, m) MS TOF 456 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.77 min. Example 2 . 1- (2-Amino-5-bromobenzoyl-D-phenylglycinyl) -4,4'- bispiperidine X H nmr (CD3CN) 7.30 (7H,m); 6.50 (lH,d); 5.85 (IH, s); 4.40 (lH,m); 3.75 (IH, m) ; 2.30-2.95 (6H, m) ; 1.60 (4H, m) ; 1.10 (6H, m) MS TOF 500 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.31 min. Example 3. 1- (2-_?_mino-4-methylbenzoyl-D-phenylglycinyl) -4,4 ' - bispiperidine iH nmr (CD 3 CN) 7.30 (6H,m); 6.50 (lH,s); 6.45 (lH,d); 5.80 (IH, S) ; 4.40 (lH,m); 3.75 (IH, m) ; 2.30-2.95 (6H, m) ; 2.05 (3H,S); 1.60 (4H, m) ; 1.10 (6H, m) MS TOF 436 (M+1 + ) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 9.22 min. Example 4. 1- (2-Amino-5-methylbenzoyl-D-phenylglycinyl) -4,4' - bispiperidine X H nmr (CD 3 CN) 7.30 (7H,m); 6.50 (lH,d); 5.85 (IH, s); 4.40 (lH,m); 3.75 (IH, m) ; 2.30-2.95 (6H, m) ; 1.60 (4H, m) ; 1.10 (6H, m) . MS TOF 436 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 8.74 min. Example 5. 1- (2-Amino-5-methoxybenzoyl-D-phenylglycinyl) -4,4 * - bispiperidine X H nmr (CD 3 CN) 7.55 (6H,m); 7.30 (lH,d); 6.95 (lH,m); 6.15 (IH, s) ; 4.40 (lH,m); 3.75 (IH, m) ; 3.60 (3H, s) ; 2.30-2.95 (6H, m) ; 2.20 (3H, s); 1.60 (4H, m) ; 1.10 (6H, m) MS TOF 452 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 8.20 min. Example 6. 1- (3-Methylbenzoyl-D-phenylglycinyl) -4,4' -bispiperidine ^-H nmr (CD 3 CN) 7.40 (2H,m) ; 7.30 (7H,m); 5.85 (IH, s) ; 4.40 (lH,m); 3.75 (IH, m) ; 2.30-2.95 (6H, m) ; 2.20 (3H, s) ; 1.60 (4H, m) ; 1.10 (6H, m) MS TOF 421 (M+1 + ) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 10.68 min. Example 7. 1- (4-Methylbenzoyl-D-phenylglycinyl) -4,4' -bispiperidine l-H nmr (CD 3 CN) 7.55 (2H,m); 7.30 (5H,m); 7.10 (2H,m); 5.85 (IH, S) ; 4.40 (lH,m); 3.75 (IH, m) ; 2.30-2.95 (6H, m) ; 2.20 (3H,s); 1.60 (4H, m) ; 1.10 (6H, m) MS TOF 420 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 10.61 mm. Example 8. 1- (3-Amino-2-naphthoyl-D-phenylglycinyl) -4,4 ' -bispiperidine 1 H nmr (CD 3 CN) 7.90 (lH,d); 7.60 (lH,d); 7.40 (lH,m); 7.30 (6H,m); 7.05 (lH,m); 6.90 (lH,s); 5.85 (IH, s) ; 4.40 (lH,m); 3.75 (IH, m) ; 2.30-2.95 (6H, m) ; 1.60 (4H, m) ; 1.10 (6H, m) MS TOF 471 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 9.87 min. Example 9. 1- (3-Aminobenzoyl-D-phenylglycinyl) -4,4' -bispiperidine MS TOF 421 (M+1 + ) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 9.06 min. Example 10 . 1- (2-Aminobenzoyl-D-phenylglycinyl) -4,4' -bispiperidine MS TOF 421 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 9.00 min. Example 11. 1- (2-Amino-4-fluorobenzoyl-D-phenylglycinyl) -4,4 ' - bispiperidine MS TOF 440 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 9.23 min. Example 12. 1- (2-Amino-5-fluorobenzoyl-D-phenylglycinyl) -4,4 * - bispiperidine MS TOF 440 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 9.14 min. Example 13. 1- (2-Amino-4-nitrobenzoyl-D-phenylglycinyl) -4,4 ■ - bispiperidine MS TOF 467 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 10.59 min. Example 14. 1- (2-Amino-5-nitrobenzoyl-D-phenylglycinyl) -4,4 ' - bispiperidine MS TOF (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 10.57 min. Example 15. 1- (2-Amino-4, 5-dimethoxybenzoyl-D-phenylglycinyl) -4,4'- bispiperidine MS TOF 481 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.67 min. Example 16. 1- (Benzoyl-D-phenylglycinyl) -4, 4 'bispiperidine MS TOF 407 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 9.88 min. Example 17. 1- (4-Chlorobenzoyl-D-phenylglycinyl) -4,4 ' -bispiperidine MS TOF 441 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 10.89 min. Example 18. 1- (2-Hydroxybenzoyl-D-phenylglycinyl) -4,4 ' -bispiperidine MS TOF 423 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 8.97 min. Method 2: By solution phase strategy: Typically an activated amino acid was treated with an amine (primary or secondary) or alcohol (leq.). Activation of the protected amino acid (Boc or Cbz protection) was by HATU/DIPEA (1:2) by TBTU/DIPEA (1:2), by HOBt or HOAt and a carbodiimide (EDCI or DCC) , or by diethyl cyanophosphonate and triethylamine or DIPEA, all couplings (minimum 120min.) were carried out in DMF without or without dichloromethane as co-solvent. After an aqueous work up the deprotection of the Boc group was achieved with TFA. Other acid substituents were added as the HOBt or HOAt esters either by activation with HBTU/HATU, EDC or DIPCI with or without Boc protection of amino groups. The final products were purified by preparative reverse phase Hplc. Examples 19-126 The compounds of Examples 19-126 were prepared by the method described below, but using the appropriate starting materials. Boc D-phenylglycine (251 mg, 1 mmol.) was dissolved in DMF(3ml) with HATU (380 mg., 1 mmol.) and DIPEA(350μl ., 2 mmol.) . To this mixture was added 4- methylbenzylamine(121mg. , 1 mmol.) and DIPEA (170μl., 1 mmol.) . The mixture was stirred overnight. The mixture was then taken up into ethylacetate and washed with water, sodium carbonate solution, water, 10% hydrochloric acid solution and water. The ethylacetate was evaporated without drying and treated immediately with TFA for 30 min. The TFA was then evaporated to dryness and the product triturated with diethylether . TEA (lml) was added and evaporated to dryness. A solution of 3-hydroxymethylbenzoic acid (76mg , 0.5mmole) in dry dimethylformamide (DMF) was treated with TBTU (161mg., 0.5mmol . ) and DIPEA (1.5 mmol.). The mixture was then added to the D-phenylglycine-4-methylbenzylamide (0.5mmol.) and stirred overnight. The crude product was dissolved in water/acetonitrile (20ml) , filtered and purified by preparative Hplc to yield pure product. -H nmr (CD 3 CN) 7.75 (IH, m) ; 7.65 (2H, m) ; 7.30 (7H, broad m) ; 6.80 (3H, m) ; 5.40 (IH, s) ; 4.45 (2H,s); 4.10 (2H, m) ; 2.10 (3H, s) . MS TOF 389 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 13.51 min. Compounds made by the above method : - Example 19 . 1- (2-Aminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyDpiperazine X H nmr (DMSO) 7.65 (3H, m) ; 7.45 (IH, m) ; 7.35 (5H, m) ; 7.15 (lH,m); 6.65 (lH,d); 6.55 (lH,m); 6.05 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m) . MS TOF 511 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 13.43 min. Example 20. 1- (2-Amino-4-chlorobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine !H nmr (DMSO) 7.55 (3H, m) ; 7.45 (IH, m) ; 7.35 (5H, m) ; 7.15 (lH,m); 6.75 (1H,S); 6.55 (lH,d); 6.05 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m) . MS TOF 546 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 15.18 min. Example 21. 1- (2-Amino-5-fluorobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CDC1 3 ) 7.75 (IH, m) ; 7.60 (IH, m) ; 7.25 (6H, m) ; 7.15 (lH,m); 6.90 (lH,m); 6.75 (lH,m); 5.85 (IH, s); 3.15 (3H,s); 3.00-2.00 (8H,m). MS TOF 529 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 13.87 min. Example 22. 1- (2-Amino-4-methylbenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine 1-H nmr (DMSO) 7.55 (3H, m) ; 7.45 (2H, m) ; 7.35 (5H, m) ; 6.65 (lH,s); 6.35 (lH,d); 6.05 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m) 2.15 (3H,s);. MS TOF 525 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 13.12 min. Example 23 . 1- (2-Amino-5-methylbenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) iperazine iH nmr (CDC1 3 ) 7.75 (IH, m) ; 7.60 (IH, m) ; 7.25 (6H, m);7.15 (lH,m) ; 6.90 (lH,m); 6.75 (lH,m); 5.85 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m) 2.30 (3H,s). MS TOF 525 (M+1 + ) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 12.84 min. Example 24. 1- (2-Amino-4-nitrobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CDCI3) 7.75 (2H, m) ; 7.55 (IH, m) ; 7.35 (7H, m) ; 7.25 (lH,m); 5.80 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m). MS TOF 556 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 15.35 min. Example 25. 1- (2-Amino-5-nitrobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) piperazine iH nmr (CDCI3) 8.25 (IH, d) ; 7.85 (IH, m) ; 7.55 (IH, m) ; 7.25 (7H, m) ; 7.05 (lH,m); 5.80 (IH, s) ; 3.15 (3H,s); 3.00- 2.00 (8H,m) . MS TOF 556 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 15.08 min. Example 26. 1- (2-Amino-5-cyanobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) iperazine iH nmr (CD3CN) 7.65 (4H, m) ; 7.25 (6H, m) ; 6.65 (lH,d); 5.80 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m). MS TOF 536 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.89 min. Example 27. 1- (2, 5-Diaminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CDC1 3 ) 7.70 (IH, d) ; 7.45 (7H, m) ; 6.85 (IH, s) ; 6.55 (IH, m) ; 6.55 (lH,m); 5.90 (IH, s); 3.15 (3H,s); 3.00- 2.00 (8H,m) . MS TOF 526 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.82 min. Example 28. 1- (2-Amino-4, 5-dimethoxybenzoyl-D-phenylglycinyl) -4- (4- fluoro-2 -methy1sulphonylpheny1) iperazine iH nmr (CD3CN) 7.65 (2H, m) ; 7.35 (2H, m) ; 7.25 (5H, m) ; 6.75 (lH,d); 6.15 (IH, d);5.80 (IH, s) ; 3.60 (3H,s); 3.50 (3H,s); 3.15 (3H,s); 3.00-2.00 (8H,m). MS TOF 571 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.84 min. Example 29. 1- (Benzoyl-D-phenylglycinyl) -4- (4-fluoro-2 -methyl- sulphonylphenyl) piperazine iH nmr (CD3CN) 7.75 (2H, m) ; 7.70 (IH, m) ; 7.40 (10H, m) ; 6.05 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m). MS TOF 496 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.84 min. Example 30. 1- (3-Aminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD3CN) 7.85 (IH, m) ; 7.60 (IH, m) ; 7.50 (2H, m) ; 7.30 (7H, m) ; 7.05 (IH, d) ; 6.05 (IH, s) ; 3.15 (3H,s); 3.00- 2.00 (8H,m) . MS TOF 511 (M+1 + ) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.32 min. Example 31. 1- (4-Aminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine X H nmr (CDC1 3 ) 7.95 (IH, d) ; 7.80-7.45 (10H, broad m) ; 7.35 (lH,d); 6.20 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m). MS TOF 511 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 12.05 min. Example 32. 1- (3,4 Diaminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylpheny1) piperazine iH nmr (CDCI3) 7.75 (IH, d) ; 7.40-7.15 (9H, broad m) ; 6.55 (lH,d); 6.00 (IH, s) ; 3.15 (3H,s); 3.00-2.00 (8H,m). MS TOF 540 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.30 min. Example 33. 1- (3-Chlorobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD3CN) 7.85 (IH, m) ; 7.80 (IH, s) ; 7.60 (2H, m) ; 7.30 (8H, m) ; 6.00 (IH, s) ; 3.20 (3H,s); 3.00-2.00 (8H,m). MS TOF 531 (M+1+). Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 15.40 min. Example 34. 1- (4-Chlorobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) iperazine X H nmr (CD3CN) 7.95 (IH, m) ; 7.75 (2H, m) ; 7.60 (IH, m) ; 7.40 (8H, m) ; 6.05 (IH, s) ; 3.25 (3H,s); 3.00-2.00 (8H,m). MS TOF 531 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 16.54 min. Example 35. 1- (3-Amino-4-chlorobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) iperazine 1 H nmr (CDC1 3 ) 8.05 (IH, m) ; 7.80 (IH, m) ; 7.70 (IH, s) ; 7.20-7.60 (8H, broad m) ; 6.05 (IH, s) ; 3.25 (3H,s); 3.00- 2.00 (8H,m) . MS TOF 546 (M+1 + ). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.53 min. Example 36. 1- (4-Bromobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD3CN) 7.85 (IH, m) ; 7.65 (2H, m) ; 7.60 (2H, d) ; 7.45 (2H, d) ; 7.30 (5H, m) ; 6.00 (IH, s) ; 3.20 (3H,s); 3.00- 2.00 (8H,m) . MS TOF 576 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 15.94 min. Example 37. 1- (4-Iodobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) piperazine iH nmr (CD3CN) ) ; 7.75 (2H, m) ; 7.65 (IH, m 7.55 (2H, d) ; 7.45 (2H, d) ; 7.30 (5H, m) ; 5.95 (IH, s) ; 3.20 (3H,s); 3.00- 2.00 (8H,m) . MS TOF 622 (M+1 + ). Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 15.96 min. Example 38. 1- (3-Amino-4-methylbenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) piperazine iH nmr (CDCI3) 7.95 (IH, s) ; 7.60 (IH, d) ; 7.45 (IH, d) ; 7.40-7.15 (8H, broad m) ; 6.00 (IH, s) ; 3.15 (3H,s); 3.00- 2.50 (8H,m) 2.20 (3H, s) . MS TOF 525 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.71 min. Example 39. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) iperazine iH nmr (CD 3 CN) 7.85 (2H, d) ; 7.65 (IH, m) ; 7.50 (2H, m) ; 7.40 (5H, m) ; 6.80 (2H, d) ; 6.00 (IH, s) ; 3.80 (3H, s) ; 3.20 (3H,s); 3.00-2.00 (8H,m). MS TOF 526 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.63 min. Example 40. 1- (3 -Amino-4 -methoxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylphenyl) piperazine iH nmr (CDC1 3 ) 7.90 (IH, m) ; 7.75 (IH, d) ; 7.60 (2H, m) ; 7.40-7.15 (6H, broad m) ; 7.45 (IH, d) ; 6.10 (IH, s) ; 3.95 (3H, s) ; 3.35 (3H,s); 3.00-2.50 (8H,m). MS TOF 541 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.78 min. Example 41. 1- (3,4-Dihydroxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CDCI3) 7.55 (IH, m) ; 7.45 (IH, d) ; 7.25 (2H, m) ; 7.15 (5H, m) ; 7.00 (IH, d) ; 6.60 (IH, d) ; 5.80 (IH, s) ; 3.05 (3H,s); 3.00-2.50 (8H,m). MS TOF 541 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.78 min. Example 42. 1- (Naphth-2-oyl-D-phenylglycinyl) -4- (4-fluoro-2 -methyl- sulphonylphenyl) piperazine iH nmr (CDCI3) 8.35 (IH, s) ; 8.00 (IH, d) ; 7.85 (5H, m) ; 7.45 (4H, m) ; 7.25 (4H, m) ; 6.10 (IH, s) ; 3.20 (3H,s); 3.00- 2.50 (8H,m) . MS TOF 546 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 16.66 min. Example 43. 1- (3-Aminonaphth-2-oyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CDCI3) 8.15 (IH, d) ; 8.00 (IH, s) ; 7.75 (2H, m) ; 7.65 (IH, d) ; 7.30 7.60 (9H, m) ; 6.10 (IH, s); 3.25 (3H,s); 3.00-2.50 (8H,m) . MS TOF 561 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 13.90 min. Example 44. 1- (Thiophene-3-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) iperazine iH nmr (CDCI3) 8.15 (IH, s) ; 7.95 (IH, m) ; 7.85 (IH, m) ; 7.60 (8H, m) ; 6.30 (IH, s); 3.45 (3H,s); 2.00-2.50 (8H,m). MS TOF 502 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 14.28 min. Example 45. 1- (Thiophene-2-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine X H nmr (CDCI3) 7.65 (2H, m) ; 7.45 (IH, s); 7.30 (2H, m) ; 7.20 (5H, m) ; 6.95 (IH, m) ; 6.00 (IH, s) ; 3.05 (3H,s); 3.00- 2.50 (8H,m) . MS TOF 502 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.52 min. Example 46. 1- (5-Methylthiophene-2-carbonyl-D-phenylglycinyl) -4- (4- fluoro-2 -methylsulphonylphenyl) piperazine iH nmr (CDCI3) 7.70 (IH, m) ; 7.45 (2H, m) ; 7.35 (6H, m) ; 6.65 (IH, m) ; 6.00 (IH, s) ; 3.05 (3H,s); 3.00-2.50 (8H,m) 2.45 (3H, s) . MS TOF 516 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.98 min. Example 47. 1- (Isoquinolin-7-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD3CN) 9.50 (IH, s) ; 8.75 (IH, s) ; 8.55 (IH, d) ; 8.30 (IH, d) ; 8.10 (2H, m) ; 7.65 (IH, m) ; 7.45 (2H, m) ; 7.35 (5H, m) ; 6.10 (IH, s) ; 3.20 (3H,s); 3.00-2.50 (8H,m). MS TOF 547 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.39 min. Example 48. 1- (Pyridin-3-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) piperazine iH nmr (CD3CN) 9.00 (IH, s) ; 8.70 (IH, d) ; 8.35 (IH, d) ; 8.10 (IH, m) ; 7.65 (2H, m) ; 7.45 (IH, m) ; 7.30 (5H, m) ; 6.00 (IH, s) ; 3.20 (3H,s); 3.00-2.50 (8H,m). MS TOF 497 (M+1+) . Hplc- (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.99 min. Example 49. 1- (Indol-6-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) piperazine iH nmr (CD3CN) 7.95 (2H, m) ; 7.60 (2H, m) ; 7.50 (3H, m) ; 7.35 (5H, m) ; 6.45 (IH, s) ; 6.05 (IH, s) ; 3.25 (3H,s); 3.00- 2.50 (8H,m) . MS TOF 535 (M+1 + ) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 15.44 min. Example 50 . 1- (2, 5-Diaminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine MS TOF 526 (M+1 + ) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.89 min. Example 51. 1- (4-Methylaminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD 3 CN) 7.65 (3H, m) ; 7.50 (2H, m) ; 7.35 (5H, m) ; 6.60 (2H, d) ; 6.05 (IH, s) ; 3.30 (3H, s) ; 3.00-2.50 (8H, m) ; 2.80 (3H, s) . MS TOF 525 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 13.17 min. Example 52. 1- (3-Methyl-4-chlorobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylpheny1) piperazine iH nmr (CD 3 CN) 7.90 (IH, s) ; 7.85 (IH, s) ; 7.80 (IH, s) ; 7.55 (6H, m) ; 6.25 (IH, s) ; 3.45 (3H, s) ; 3.00-2.50 (8H, m) ; 2.60 (3H, s) . MS TOF 545 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 16.39 min. Example 53. 1- (4-Vinylbenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylphenyl) piperazine iH nmr (CD 3 CN) 7.75 (2H, d) ; 7.60 (IH, m) ; 7.45 (4H, m) ; 7.35 (5H, m) ; 6.75 (IH, m) ; 6.05 (IH, s) ; 5.90 (IH, d) ; 5.30 (IH, d) ; 3.00-2.50 (8H, m) ; 2.80 (3H, s) . MS TOF 522 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 15.45 min. Example 54. 1- (3-Amino-4-hydroxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylpheny1) piperazine iH nmr (CD 3 CN) 7.60 (IH, m) ; 7.50-7.10 (9H, m) ; 7.35 (IH, d); 5.95 (IH, s); 3.25 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 527 (M+1+) . Hplc (Magellan C8, Gradient 2, water/acetonitrile/TFA) rt 15.46 min. Example 55. 1- (4-Methylthiobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2 - methylsulphonylphenyl) piperazine iH nmr (CD 3 CN) 7.85 (2H, d) ; 7.80 (IH, m) ; 7.60 (2H, m) ; 7.50 (5H, m) ; 7.40 (2H, d) ; 6.15 (IH, s) ; 3.40 (3H, s) ; 3.10-2.70 (8H, m) ; 2.60 (3H, s) . MS TOF 542 (M+1 + ). Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 16.67 min. Example 56. 1- (3-Carboxamidobenzoyl-D-phenylglycinyl) -4- (4 -fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD 3 CN) 8.25 (IH, s) ; 7.95 (2H, d) ; 7.70 (IH, m) ; 7.55 (3H, m) ; 7.40 (5H, m) ; 6.05 (IH, s) ; 3.30 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 539 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 12.83 min. Example 57. 1- (3-Amino-4-methylbenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylphenyl) iperazine X H nmr (CD3CN) 7.90 (IH, d) ; 7.70 (IH, m) ; 7.55 (2H, m) ; 7.45 (5H, m) ; 7.20 (IH, s) ; 6.95 (IH, d) ; 6.05 (IH, s) ; 3.80 (3H, s) ; 3.30 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 569 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.49 min. Example 58. 1- (3-Methyl-4-bromobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD 3 CN) 7.65 (3H, m) ; 7.45 (3H, m) ; 7.30 (5H, m) ; 6.00 (IH, s) ; 3.25 (3H, s) ; 3.00-2.50 (8H, m) ; 2.40 (3H, s) . MS TOF 589 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 16.67 min. Example 59. 1- (4-Ethoxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) iperazine iH nmr (CD 3 CN) 7.75 (2H, d) ; 7.60 (IH, m) ; 7.50 (2H, m) ; 7.35 (5H, m) ; 6.85 (2H, d) ; 6.00 (IH, s) ; 4.00 (2H, m) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) ; 1.30 (3H, t) . MS TOF 540 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 16.58 min. Example 60. 1- (Indol-5-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD 3 CN) 8.15 (IH, s) ; 7.95 (IH, m) ; 7.65 (2H, m) ; 7.60-7.35 (7H, m) ; 6.60 (IH, s); 6.10 (IH, s) ; 3.30 (3H, s) ; 3.00-2.60 (8H, m) . MS TOF 535 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 13.88 min. Example 61. 1- (Benzimidazo-5-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine iH nmr (CD 3 CN) 8.75 (IH, s) ; 8.25 (IH, s) ; 7.75 (2H, m) ; 7.60 (IH, m) ; 7.50 (2H, m) ; 7.35 (5H, m) ; 6.60 (2H, d) ; 6.05 (IH, s) ; 3.30 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 536 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 10.08 min. Example 62. 1- (3-Aminobenzoyl-D-phenylglycinyl) -1 ' -methyl-4, 4 ' - bispiperidine iH nmr (CD3CN) a mixture of conformers only one recorded here 7.65 (IH, m) ; 7.35 (5H, m) ; 7.05 (IH, m) ; 6.95 (2H, m) ; 5.85 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.55 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 435 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 7.65 min. Example 63. 1- (3 -Amino-4 -chlorobenzoyl-D-phenylglycinyl) -1 ' -methyl-4 ,4 ' - bispiperidine iH nmr (CD3CN) a mixture of conformers only one recorded here 7.75 (IH, m) ; 7.30 (5H, m) ; 7.20 (IH, m) ; 6.95 (IH, m) ; 5.85 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.55 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 469 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 9.58 min. Example 64. 1- (3 -Amino-4 -methylbenzoyl-D-phenylglycinyl) -1 ' -methyl-4, 4 ' - bispiperidine iH nmr (CD3CN) a mixture of conformers only one recorded here 7.75 (IH, m) ; 7.35 (5H, m) ; 7.05 (2H, m) ; 5.85 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.65 (3H, s) ; 2.15 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 449 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 8.03 min Example 65. 1- (3-Aminonaphth-2-oyl-D-phenylglycinyl) -1' -methyl-4, 4 ' - bispiperidine iH nmr (CD3CN) a mixture of conformers only one recorded here 7.95 (IH, m) ; 7.65 (IH, d) ; 7.45 (2H, m) ; 7.30 (5H, m) ; 7.15 (IH, m) ; 6.95 (IH, s) 5.95 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.65 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 485 (M+1 + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 9.94 min. Example 66. 1- (Indol-6-carbonyl-D-phenylglycinyl) -1 ' -methyl-4 , 4 ' - bispiperidine iH nmr (CD3CN) a mixture of conformers only one recorded here7.78 (2H, s) ; 7.50 (IH, d) ; 7.25 (7H, m) ; 6.34 (IH, s) ; 6.82 (IH, s) ; 4.40 (IH, m) ; 3.83 (IH, m) ; 3.35 (2H, t); 2.9- 2.4 (8H, m) and 2.65 (3H, s) masked by water in solvent; 1.60 (2H, m) ; 1.40 (2H, m) ; 1.08 (2H, m) . MS TOF 459 (M+1+) . Hplc (Luna2 C18, Gradient 3, water/acetonitrile/TFA rt 10.01 min. Example 67. 1- (3 -Amino-4 -fluorobenzoyl-D-phenylglycinyl) -1 ' -methyl-4, 4 ' - bispiperidine iH nmr (d4 methanol) a mixture of conformers only one recorded here 7.4 (6H, m) ; 7.1 (IH, m) ; 7.0 (IH, t) ; 6.0 (IH, s) ; 4.63 (IH, m) ; 4.02 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 ( 8H , m) ; 2 . 65 ( 3H , s ) ; 1 . 60 ( 2H , m) ; 1 . 30 ( 2H , m) ; 1 . 00 ( 2H , m) . MS TOF 453 (M+ 1+ ) . Hplc (Symmetry C8, Gradient 3, water/acetonitrile/TFA) rt 5.03 min. Example 68. 1- (3-Amino-4-bromobenzoyl-D-phenylglycinyl) -1' -methyl-4, 4 ' - bispiperidine iH nmr (CD3CN) a mixture of conformers only one recorded here 7.75 (IH, m) ; 7.35 (5H, m) ; 7.05 (IH, m) ; 6.80 (IH, m) ; 5.85 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) and 2.65 (3H, s) masked by water in solvent; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 513 and 515 (M+1+) . (Symmetry C8, Gradient 3, water/acetonitrile/TFA) rt 5.70 min. Example 69. 1- (3-Amino-4-methoxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4 ' -bispiperidine iH nmr (CD3CN) a mixture of conformers only one recorded here 7.70 (IH, m) ; 7.30 (5H, m) ; 7.0 (2H, m) ; 6.72 (IH, d) ; 5.80 (IH, s) ; 4.45 (IH, m) ; 3.85(1H, m) ; 3.70 (3H, s) ; 3.30 (2H, m) ; 2.9-2.4 (8H, m) masked by water in solvent; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 465 (M+1+). Hplc (Luna2 C18, Gradient 3, water/acetonitrile/TFA) rt 7.55 min. Example 70. 1- (4- (Methylamino)benzoyl-D-phenylglycinyl) -1 ' -methyl-4, 4 ' - bispiperidine iH nmr (CD3CN) a mixture of conformers only one recorded here 7.70 (3H, m) ; 7.35 (5H, m) ; 6.60 (2H, d) ; 5.90 (IH, S) ; 4.45 (IH, m) ; 3.85.1H, m) ; 3.40 (2H, m) ; 2.9-2.4 (8H, m) ; 2.70 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 465 (M+1+) . Hplc (Luna2 C18, Gradient 3, water/acetonitrile/TFA) rt 8.52 min. Example 71. 1- (4-Ethylaminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylphenyl) piperazine IH nmr (CD3CN) 7.65 (3H, m) ; 7.45 (2H, m) ; 7.35 (5H, m) ; 6.60 (2H, d) ; 6.00 (IH, s) ; 3.20 (3H, s) ; 3.10 (2H, q) ; 3.00-2.50 (8H, m) ; 1.15 (3H, t) . MS TOF 539 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.57 min. Example 72. 1- (3-Methylaminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) iperazine IH nmr (CD3CN) 7.75 (IH, d) ; 7.60 (IH, d) ; 7.35 (7H, m) ; 7.15 (IH, t) ; 7.00 (IH, m) ; 6.70 (IH, d) ; 6.00 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) ; 2.70 (3H, s) . MS TOF 525 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 12.07 min. Example 73. 1- (4-Chloro-3-aminobenzoyl-D-phenylglycinyl) -4- (2- methy1sulphonylphenyl) iperazine IH nmr (CD3CN) 7.95 (IH, d) ; 7.60 (IH, m) ; 7.45 (10H, m) ; 7.00 (IH, d) ; 6.00 (IH, s); 3.25 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 527 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 13.56 min. Example 74. 1- (4-Trifluoromethoxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.85 (3H, ttl) ; 7.65 (IH, d) ; 7.45 (2H, m) ; 7.35 (6H, m) ; 6.00 (IH, s) ; 3.25 (3H, s); 3.00-2.50 (8H, m) . MS TOF 580 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 16.01 min. Example 75. 1- (4-Difluoromethoxybenzoyl-D-phenylglycinyl) -4- (4 -fluoro-2 - methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.85 (3H, m) ; 7.45 (2H, d) ; 7.30 (5H, m) ; 7.15 (2H, d) ; 6.80 (IH, t); 6.00 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 562 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.99 min. Example 76. 1- (4-Trifluoromethylbenzoyl-D-phenylglycinyl) -N- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.85 (2H, d) ; 7.70 (2H, d) ; 7.45 (2H, m) ; 7.35 (6H, m) ; 6.00 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 564 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 15.00 min. Example 77. 1- (Indol-3-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 8.05 (lH,s); 7.85 (IH, d) ; 7.70 (IH, m) ; 7.50 (2H, m) ; 7.35 (6H, m) ; 7.20 (2H, m) ; 6.15 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 535 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 14.25 min. Example 78 . 1- (4-Chloro-3-aminobenzoyl-L-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.75 (IH, d) ; 7.60 (IH, d) ; 7.45 (8H, m) ; 6.90 (IH, d) ; 5.95 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 545 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 14.53 min. Example 79. 1- (2-Carboxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.75 (IH, d) ; 7.60 (IH, d) ; 7.50 (IH, d) ; 7.25-7.50 (9H, m) ; 6.00 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 540 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.19 min. Example 80. 1- (2-Fluorobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.85 (IH, m) ; 7.60 (IH, d) ; 7.25-7.50 (10H, m) ; 6.00 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 514 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 13.29 min. Example 81. 1- (3-Bromoindol-6-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.85 (2H, m) ; 7.70-7.20 (10H, m) ; 6.05 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 614 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 16.16 min. Example 82. 1- (3-Chloroindol-6-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) iperazine IH nmr (CD3CN) 7.95 (2H, m) ; 7.70-7.30 (10H, m) ; 6.05 (IH, s) ; 3.25 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 570 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 16.18 min. Example 83. 1- (2-Cyanobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.25-7.80 (12H, m) ; 6.05 (IH, s); 3.25 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 521 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.85 min. Example 84. 1- (2-Aminomethylbenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- ethy1sulphonylphenyl) iperazine IH nmr (CD3CN) 7.95 (2H, m) ; 7.80-7.35 (10H, m) ; 6.15 (IH, s) ; 4.30 (2H, s); 3.15 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 525 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.21 min. Example 85. 1- (4-Carboxy-3-aminobenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylphenyl) iperazine IH nmr (CD3CN) 7.75 (IH, d) ; 7.60 (IH, d) ; 7.45 (7H, m) ; 7.15 (IH, s) ; 6.85 (lH,d); 5.95 (IH, s) ; 3.25 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 554 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 13.00 min. Example 86 . 1- (lH-Indazol-6-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methy1sulphonylphenyl) piperazine IH nmr (CD3CN) 8.05 (2H,m); 7.85 (IH, d) ; 7.70 (IH, d) ; 7.55 (2H, m) ; 7.45 (5H, m) ; 5.95 (IH, s) ; 3.30 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 545 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 13.44 min. Example 87. 1- (4-Methylcarboxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.95 (2H, m) ; 7.80 (2H, m) ; 7.45 (2H, m) ; 7.35 (6H, m) ; 6.00 (IH, s) ; 3.90 (3H, s); 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 554 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 14.90 min. Example 88. 1- (4-Acetoxybenzoyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) iperazine IH nmr (CD3CN) 7.75 (3H, m) ; 7.60 (IH, d) ; 7.45 (2H, m) ; 7.35 (5H, m) ; 7.10 (2H,d); 6.00 (IH, s) ; 3.20 (3H, s) ; 3.00- 2.50 (8H, m) ; 2.20 (3H,s).MS TOF 554 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.53 min. Example 89. 1- (5-Methylpyrazin-2-carbonyl-D-phenylglycinyl) -4- (4-fluoro- 2 -methylsulphonylphenyl) piperazine IH nmr (CD3CN) 8.90 (lH,s); 8.35 (lH,s); 7.55 (IH, m) ; 7.40 (2H, m) ; 7.25 (5H, m) ; 5.85 (IH, s) ; 3.10 (3H, s) ; 3.00-2.50 (8H, m) ; 2.40 (3H, s) . MS TOF 512 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.17 min. Example 90 . 1- (1, 3-Benzodioxol-5-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.55 (2H, m) ; 7.35 (2H, m) ; 7.25 (6H, m) ; 6.70 (lH,d); 5.85 (2H,s); 5.80 (IH, s) ; 3.10 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 540 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.28 min. Example 91. 1- (4- (Methylsulphonyl)benzoyl-D-phenylglycinyl) -4- (4-fluoro- 2 -methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.95 (3H, m) ; 7.60 (IH, m) ; 7.50 (2H,m); 7.35 (6H, m) ; 6.05 (IH, s) ; 3.25 (3H,s); 3.10 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 574 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 13.62 min. Example 92. 1- (2, 3-Dichloroindol-6-carbonyl-D-phenylglycinyl) -4- (4-fluoro-2' methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.90 (lH,d); 7.85 (lH,s); 7.55 (2H, m) ; 7.40 (2H, m) ; 7.25 (5H, m) ; 6.05 (IH, s) ; 3.30 (3H, s) ; 3.00-2.50 (8H, m) ; 2.40 (3H, s) . MS TOF 614 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 16.35 min. Example 93. 1- (3-Chloro-2-oxo- (IH) indol-6-carbonyl-D-phenylglycinyl) -4- (4- fluoro-2 -methy1sulphonylphenyl) piperazine IH nmr (CD3CN) 7.90 (lH,d); 7.55 (IH, m) ; 7.25-7.50 (9H, m) ; 5.95 (IH, s) ; 5.20 (lH,s); 3.20 (3H, s); 3.00-2.50 (8H, m) . MS TOF 585 (M+1+) . Hplc (Magellan C8 . Gradient 3, water/acetonitrile/TFA) rt 14.38 min. Example 94. 1- (3,3-Dichloro-2-oxo- (IH) indol-6-carbonyl-D-phenylglycinyl) 4- (4-fluoro-2 -methylsulphonylphenyl) -piperazine IH nmr (CD3CN) 7.90 (lH,d); 7.65 (2H,m); 7.55 (IH, m) ; 7.45 (2H,m) ; 7.35 (5H, m) ; 5.95 (IH, s) ; 3.25 (3H, s) ; 3.00-2.50 (8H, ) . MS TOF 619 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 15.13 min. Example 95. 1- (3-Methylindol-6-carbonyl-D-phenylglycinyl) -1 ' -methyl-4 ,4 ' bispiperidine IH nmr (CD3CN) a mixture of conformers only one recorded here 7.85 (2H, m) ; 7.40 (3H, m) ; 7.30 (3H, m) ; 7.05 (IH, s) ; 5.95 (IH, s) ; 4.55 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.55 (3H, s) ; 2.20 (3H,s); 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 473 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.40 min. Example 96. 1- (2,3-Dihydroindol-6-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4 ' -bispiperidine IH nmr (CD3CN) a mixture of conformers only one recorded here 7.75 (IH, m) ; 7.30 (7H, m) ; 5.85 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.65 (2H,t); 3.30 (2H, m) ; 3.10 (2H,t); 2.90-2.40 (8H, m) ; 2.55 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 461 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 8.68 min. Example 97. 1- (lH-indazol-6 -carbonyl-D-phenylglycinyl) -1" -methyl-4, 4 ' - bispiperidine IH nmr (CD3CN) a mixture of conformers only one recorded here 7.95 (IH, m) ; 7.85 (2H,m); 7.65 (lH,m); 7.45 (2H, m) ; 7.30 (3H, m) ; 5.95 (IH, s) ; 4.55 (IH, m) ; 3.95 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.55 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 460 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 9.72 min. Example 98. 1- (Benzimidazol-5-carbonyl-D-phenylglycinyl) -1 ' -methyl-4, 4 ' - bispiperidine IH nmr (CD3CN) a mixture of conformers only one recorded here. 8.05 (lH,s); 7.90 (lH,m); 7.75 (2H, m) ; 7.30 (5H, m) ; 5.95 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.75 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 460 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 8.80 min. Example 99. 1- (Benzthiazol-6-carbonyl-D-phenylglycinyl) -1 ' -methyl-4, 4 ' - bispiperidine IH nmr (CD3CN) a mixture of conformers only one recorded here 8.40 (lH,s); 7.95 (3H, m) ; 7.30 (5H, m) ; 5.85 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.65 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 477 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 9.58 min. Example 100 . 1- (3-Chloroindol-6-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4 ' -bispiperidine IH nmr (CD3CN) a mixture of conformers only one recorded here 7.85 (2H, m) ; 7.30 (7H, m) ; 5.85 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.65 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 493 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 12.22 min. Example 101. 1- (3 -Bromoindol-6-carbonyl-D-phenylglycinyl) -1 ' -methyl-4,4 ' - bispiperidine IH nmr (CD3CN) a mixture of conformers only one recorded here 7.85 (2H, m) ; 7.30 (7H, m) ; 5.85 (IH, s) ; 4.45 (IH, m) ; 3.85 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.65 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 539 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.45min. Example 102. 1- (3-Amino-4-chlorobenzoyl- -phenylglycinyl) -1' -methyl-4,4' - bispiperidine IH nmr (CDC13) a mixture of conformers only one recorded here 7.65 (IH, m) ; 7.30 (6H, m) ; 7.00 (lH,m); 5.85 (IH, s) ; 4.65 (IH, m) ; 3.80 (IH, m) ; 3.55 (2H, m) ; 2.90-2.40 (8H, m) ; 2.65 (3H, S) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 469 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 10.71min. Example 103 . 1- (4-Vinylbenzoyl-D-phenylglycinyl) -1 ' -methyl-4, 4 ' - bispiperidine IH nmr (CD3CN) a mixture of conformers only one recorded here 7.85 (IH, m) ; 7.70 (2H,m); 7.40 (6H, m) ; 6.75 (lH,m); 6.00 (IH, s) ; 5.85 (lH,d); 5.50 (lH,d); 4.55 (IH, m) ; 3.95 (IH, m) ; 3.30 (2H, m) ; 2.90-2.40 (8H, m) ; 2.65 (3H, s) ; 1.60 (2H, m) ; 1.30 (2H, m) ; 1.00 (2H, m) . MS TOF 446 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.21min. Example 104. 1- (3 -Amino-4 -chlorobenzoyl-D-phenylglycinyl) -4- (4-amino-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.55 (IH, m) ; 7.45 (3H, m) ; 7.35 (5H, m) ; 7.10 (lH,d); 6.90 (IH, d) ; 6.10 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 542 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 12.02 min. Example 105. 1- (3 -Aminobenzoyl-D-phenylglycinyl) -4- (4-amino-2 -methyl sulphonylphenyl) piperazine IH nmr (CD3CN) 7.55 (2H, m) ; 7.45 (3H, m) ; 7.35 (5H, m) ; 7.10 (lH,d); 6.90 (IH, d) ; 6.10 (IH, s) ; 3.10 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 508 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 9.35 min. Example 106. 1- (3-Amino-4-chlorobenzoyl-D-phenylglycinyl) -4- (4-carboxamido- 2 -methylsulphonylphenyl) piperazine IH nmr (CD3CN) 8.05 (lH,d); 7.80 (IH, m) ; 7.35-7.60 (8H, m) ; 7.10 (lH,d); 6.10 (IH, s) ; 3.25 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 570 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.24 min. Example 107. 1- (3-Amino-4-chlorobenzoyl-D-phenylglycinyl) -4- (4-nitro-2- methylsulphonylphenyl) piperazine IH nmr (CD3CN) 8.70 (lH.s); 8.45 (lH,d); 7.55 (IH, m) ; 7.45 (5H, m) ; 7.30 (2H, m) ; 7.10 (lH,d); 6.10 (IH, s) ; 3.40 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 572 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.25 min. Example 108. 1- (3-Amino-4-chlorobenzoyl-D-4-aminophenylglycinyl) -4- (4- fluoro-2 -methy1sulphonylphenyl) piperazine IH nmr (CD3CN) 7.65 (IH, d) ; 7.45 (4H, m) ; 7.25 (2H, m) ; 7.15 (2H,d); 7.05 (IH, d) ; 6.10 (IH, s) ; 3.20 (3H, s); 3.00-2.50 (8H, m) . MS TOF 560 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.90 min. Example 109. 1- (3-Amino-4-chlorobenzoyl-D-4-carboxamidophenylglycinyl) -4- (4-fluoro-2-methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.70 (2H, d) ; 7.55 (IH, d) ; 7.45 (2H, d) ; 7.25 (2H,m); 7.20 (2H,d); 6.90 (IH, d) ; 6.10 (IH, s) ; 3.20 (3H, s) ; 3.00-2.50 (8H, m) . MS TOF 588 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.18 min. Example 110. 1- (3 -Amino-4 -chlorobenzoyl-D-4- (methylcarboxamido) phenyl- glycinyl) -4- (4-fluoro-2 -methylsulphonylphenyl) piperazine IH nmr (CD3CN) 7.70 (2H, d) ; 7.55 (IH, d) ; 7.45 (2H, d) ; 7.25 (2H,m) ; 7.20 (2H,d); 6.90 (IH, d) ; 6.10 (IH, s) ; 3.20 (3H, s) ; 2.70 (3H,s); 3.00-2.50 (8H, m) . MS TOF 602 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 12.70 min. Example 111. 3-Amino-4-chlorobenzoyl-D-phenylglycine 4-methylbenzylamide IH nmr (CD3CN) 7.55 (IH, m) ; 7. 35 (7H,m); 7.00 (4H,m); 5.45 (IH, s); 4.25 (2H,m); 2.20 (3H, s) . MS TOF 408 (M+1+). Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.61 min. Example 112. 3-Amino-4-chlorobenzoyl-D-4-carboxamidophenylglycine R,S -2- methylcyclohexylamide IH nmr (CD3CN) mixture of isomers only one recorded here 7.75 (2H, d) ; 7. 60 (2H,m); 7.30 (2H,m); 7.10 (lH,d); 5.55 (IH, s) ; 3.90 (lH,m); 3.25 (lH,m); 1.00-2.00 (8H,m) 0.50 (3H, m) . MS TOF 443 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 9.18 min Example 113. 3 -Amino-4-chlorobenzoyl-D-4-carboxamidophenylglycine 2 - indanamide MS TOF 463 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.58 min. Example 114. 3-Amino-4-chlorobenzoyl-D-4-carboxamidophenylglycine (S) -N - benzyl-alpha-methylbenzylamide MS TOF 541 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 15.34 min. Example 115. 3-Amino-4-chlorobenzoyl-D-4-carboxamidophenylglycine 1- (S) -1- naphthylethylamide MS TOF 5013 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 14.00 min. Example 116. 3-Amino-4-chlorobenzoyl-D-4-carboxamidophenylglycine 3- (1- (R,S) -hydroxyethyDbenzamide MS TOF 443 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.81 min. Example 117. 3-Amino-4-chlorobenzoyl-D-phenylglycine cis, trans-2- aminocyclohexylamide MS TOF 401 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.00 min. Example 118. 1- (3-Amino-4-chlorobenzoyl-D,L- (4-piperidinyl) glycinyl) -4- (4- fluoro-2-methylsulphonylphenyl) piperazine MS TOF 552 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 11.00 min. Example 119. 1- (3-Amino-4-chlorobenzoyl-D,L- (4-N-methylpiperidinyl) - glycinyl) -4- (4-fluoro-2-methylsulphonylphenyl) piperazine MS TOF 566 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 10.83 min. Example 120 . 1- (3-Amino-4-chlorobenzoyl-D,L- (4-N-trifluoroacetyl- piperidinyl)glycinyl-4- (4-fluoro-2-methylsulphonylphenyl) - piperazine MS TOF 649 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.63 min. Example 121. 3 -Amino-4-chlorobenzoyl-D-phenylglycine (2-chloro-5- carboxamido)benzenesulphonamide MS TOF 521 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 10.23 min. Example 122. 1- (4-Cyanobenzoyl-D-phenylglycinyl) -1' -methyl-4,4 ' - bispiperidine MS TOF 445 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 10.13min. Example 123. 1- (3-Cyanobenzoyl-D-phenylglycinyl) -1 ' -methyl-4,4 ' - bispiperidine MS TOF 445 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 10.23min. Example 124. 1- (4-Chlorobenzoyl-D-phenylglycinyl) -4- (4-pyridyl) -piperazine MS TOF 435 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.11 min. Example 125 . 1- (4 -Methoxybenzyl-D-phenylglycinyl) -4- (4-fluoro-2- methylsulphonylphenyl) piperazine MS TOF 512 (M+1+) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 11.91 min. Example 126. 1-N- (3 -Amino-4 -chlorobenzoyl) -2-N- (4-methoxybenzoyl) -1,2- diamino-1-phenylethane IH nmr (CD30H) 7.45 (2H, m) ; 7. 35 (3H,m); 7.20 (2H,m);7.10 (3H,m) ; 6.75 (2H,d); 4.80 (IH, m) ; 4.25 (2H,m); 3.70 (3H, s) . MS TOF 424 (M+1+) . Hplc (Magellan C8 , Gradient 3, water/acetonitrile/TFA) rt 14.05 min. Examples 127 to 136. Preparation of Starting Materials 4 -methoxybenzoyl-D-phenylglycinyl-R, S-3-hydroxypyrrolidine D-phenylglycinyl-R, S-3-hydroxypyrrolidine (3.42g, 15.5mmol) was dissolved in dichloromethane (100ml) and placed under argon. Triethylamine (2.27ml, 16.28mmol) was added followed by 4-methoxybenzoyl chloride (2.78g, 16.3mmol) and the mixture stirred at room temperature for 3.5h. The organic solution was washed with 0.5% hydrochloric acid (50ml), sat. sodium bicarbonate solution (50ml) and brine (50ml) . The organic solution was dried (MgS04) and evaporated to an off- white solid, 4-methoxybenzoyl -D-phenylglycinyl-R, S-3- hydroxypyrrolidine, (5.49g, 100%) Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 11.7min LCMS M+l 355 Nmr. 4- ethoxybenzoyl-D-phenylglycinyl-4 -hydroxypiperidine By a similar method D-phenylglycinyl-4 -hydroxypiperidine was converted to 4 -methoxybenzoyl -D-phenylglycinyl-4- hydroxypiperidine . Hplc (Luna C18, Gradient3 , water/acetonitrile/TFA), rt , 11.9min LCMS M+l 369 Nmr Example 127 1- (4-Methoxybenzoyl-D-phenylglycinyl) -3- (R,S) - (2- fluorophenoxy) yrrolidine To a solution of 4-methoxybenzoyl-D-phenylglycinyl-R, S-3- hydroxypyrrolidine (400mg, 1.13mmol) in benzene (10ml) at 10°C was added 2-triphenylphosphonium 4 , 4 -dimethyl- tetrahydro-1, 2, 5-thiadiazolidine 1,1-dioxide (Reference: J. Castro et al . J. Org. Chem. 1994, 59, 2289-2291) (696mg, 1.69mmol) and 3-methoxyphenol (210mg) and the mixture allowed to warm to room temperature overnight. The reaction mixture was diluted with ether (30ml) and washed with dilute sodium bicarbonate solution. The organic solution was dried (MgSθ4) and concentrated. The residue was purified by by reverse phase preparative chromatography to give l-(4- methoxybenzoyl-D-phenylglycinyl) -3- (R,S) - (3- methoxyphenoxy) pyrrolidine . Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 11.75min. LCMS M+l 461 Nmr (mixture of diastereomers) . Example 128. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -3- (R,S) - (3- methoxyphenoxy) pyrrolidine From 4-methoxybenzoyl-D-phenylglycinyl-R, S-3- hydroxypyrrolidine and 3-methoxyphenol : Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 11.75min. LCMS M+l 461 Nmr (mixture of diastereomers) . Example 129. 1- (4-methoxybenzoyl-D-phenylglycinyl) -4- (3- methoxyphenoxy) piperidine From 4 -methoxybenzoyl-D-phenylglycinyl -4 -hydroxypiperidine and 3-methoxyphenol: Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 16.09min LCMS M+l 475. Nmr Example 130. 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4- (4- methoxyphenoxy) piperidine From 4 -methoxybenzoyl-D-phenylglycinyl-4 -hydroxypiperidine and 4-methoxyphenol : Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt , 15.8min. LCMS M+l 475. Nmr. Example 131. 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4- (3- fluorophenoxy) piperidine From 4 -methoxybenzoyl -D-phenylglycinyl-4 -hydroxypiperidine and 3-fluorophenol : Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 12.75min. LCMS M+l 463 Nmr Example 132 . 1- (4-methoxybenzoyl-D-phenylglycinyl) -4- (2- methanesulfonylphenoxy) piperidine From 4 -methoxybenzoyl-D-phenylglycinyl -4 -hydroxypiperidine and 2-methanesulphonylphenol : Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 10.8min. LCMS M+l 523 Nmr. Example 133. 1- (4-methoxybenzoyl-D-phenylglycinyl) -4- (2- methylmercaptophenoxy) piperidine From 4 -methoxybenzoyl-D-phenylglycinyl -4 -hydroxypiperidine and 2-methylmercaptophenol : Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 12.7min LCMS M+l 491 Nmr. Example 134. 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4- (2-fluoro- phenoxy) piperidine From 4 -methoxybenzoyl -D-phenylglycinyl -4 -hydroxypiperidine and 2- fluorophenol : Hplc (Luna C18, Gradient3 , water/acetonitrile/TFA), rt, 15.8min. LCMS M+l 463 Nmr. Example 135. 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4- (phenoxy) piperidine From 4 -methoxybenzoyl-D-phenylglycinyl-4 -hydroxypiperidine and phenol : Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 16.8min. LCMS M+l 445 Example 136. 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4- (3- pyridoxy) piperidine From 4 -methoxybenzoyl-D-phenylglycinyl- -hydroxypiperidine and 3-hydroxypyridine: Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 11.4min LCMS M+l 446 Nmr Example 137. 1- (4-methoxybenzoyl-D-phenylglycinyl) -4- (4- fluorophenoxy) piperidine To a solution of triphenylphosphine (285mg, 1.09mmol) in dry THF (5ml) under argon at -15°C was added slowly (<-10°C) diethyl azodicarboxylate (DEAD) (208mg, 1.19mmol) and the solution stirred at <-10°C for 5min. To this mixture was added a solution of 4 -methoxybenzoyl -D-phenylglycinyl -4- hydroxypiperidine (400mg, l.Oδmmol) and 4-fluorophenol (122mg, 1.09mmol) in dry THF (5ml) over 5min at <-10°C. The reaction was warmed to room temperature and monitored by tic (Siθ2 - ethyl acetate) . The reaction mixture was poured into water (5ml) and extracted with dichloromethane (100ml) . The organic solution was washed with sat . sodium bicarbonate (50ml) and 0.5% hydrochloric acid (50ml), dried (MgS0 4 ) and concentrated and the residue purified by flash chromatography, (Siθ2 - 30% ethyl acetate in hexane to give 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4- (4- fluorophenoxy) piperidine, (107mg, 21%) Hplc (Luna C18, Gradient3 , water/acetonitrile/TFA), rt, 16. Omin LCMS M+l 463. Nmr. Examples 138 to 142 Preparation of Starting Materials Benzyloxycarbonyl-D-phenylglycinyl-R, S-3-hydroxypyrrolidine Benzyloxycarbonyl-D-phenylglycine (lδ.Olg, 63.1mmol) and R, S-3-hydroxypyrrolidinol (5.0g, 57.4mmol) were suspended in dimethylformamide (300ml). HOAt (8.61g, 63.1mmol) was added, the mixture stirred for 3min. and then EDCI (12.1g 63.1mmol) was added with stirring and the mixture left overnight . The orange solution was concentrated in vacuo and the residue taken up in ethyl acetate (300ml) . The organic solution was washed with sat. sodium bicarbonate (2 x 100ml), 0.5% aqueous hydrochloric acid (50ml) and brine (100ml) . The organic solution was dried (MgS04) and evaporated in vacuo to give an orange solid. Flash chromatography (Siθ2 1:1 dichloromethane: ethyl acetate gave benzyloxycarbonyl -D- phenylglycinyl-R, S-3-hydroxypyrrolidine, (11.4g, 56%). Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt , 12.7min LCMS M+l 355 Nmr. Benzyloxycarbonyl-D-phenylglycinyl-4 -hydroxypiperidine By a similar method using benzyloxycarbonyl -D-phenylglycine and 4 -hydroxypiperidine, benzyloxycarbonyl-D-phenylglycinyl- 4 -hydroxypiperidine was prepared. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 11.9min LCMS M+l 369 Nmr. D-Phenylglycinyl-R, S-3-hydroxypyrrolidine Benzyloxycarbonyl-D-phenylglycinyl-R, S-3-hydroxypyrrolidine, (5.49g, 15.5mmol) was dissolved in ethanol (120ml) and Pd/C (10%, lOOmg) added. The mixture was hydrogenated at atmospheric pressure until complete by tic (Siθ 2 ethyl acetate - starting material Rf . 0.6, product 0.05). The catalyst was filtered off through celite and concentrated in vacuo to give D-phenylglycinyl-R, S-3-hydroxypyrrolidine as a yellow oil, (3.54g, 16.1mmol). D-Phenylglycinyl-4-hydroxypiperidine By a similar method benzyloxycarbonyl-D-phenylglycinyl-4- hydroxypiperidine was converted to D-phenylglycinyl-4- hydroxypiperidine Benzyloxycarbonyl-D-phenylglycinyl-4- (3 -pyridoxy) piperidine To a solution of benzyloxycarbonyl-D-phenylglycinyl-4- hydroxypiperidine (500mg, 1.36mmol), 3-hydroxypyridine (129mg, 1.36mmol) and triphenylphosphine (356mg, 1.36mmol) in dry THF (20ml) at 0°C, was slowly added diethyl azodicarboxylate (259mg, 1.19mmol) and the mixture stirred for lh at 0°C and then 16h at room temperature. Water (5ml) was added and the mixture extracted with ethyl acetate (2 x 10ml) . The organic solution was washed with water and brine, dried (MgS0 ) and concentrated to an oil which was purified by flash chromatography, (Siθ2 - hexane/ethyl acetate 1:1) to give benzyloxycarbonyl-D-phenylglycinyl-4- (3- pyridoxy) piperidine, (490mg 65% - contaminated with triphenylphosphine) Benzyloxycarbonyl-D-phenylglycinyl-R, S-3- (3-pyridoxy) - pyrrolidine A solution of benzyloxycarbonyl-D-phenylglycinyl-R, S-3- hydroxypyrrolidine (2.0g, 8.64mmol), 2-triphenylphosphonium 4 , 4-dimethyl-tetrahydro-l, 2 , 5-thiadiazolidine 1,1-dioxide (Reference: J. Castro et al . J. Org. Chem. 1994, 59, 2289- 2291) (3.479g, 8.47mmol) and 3-hydroxypyridine (0.805g, 8.47mmol) in benzene (30ml) was stirred at room temperature for 18h. The mixture was poured onto ether (50ml) and the organic solution was washed with sat. sodium bicarbonate (2 x 50ml) . The product was extracted into 5% hydrochloric acid which was then basified (pH8) with 2M sodium hydroxide solution and extracted with ether (3 x 100ml) . The organic solution was dried ( gS0 4 ) and evaporated to give benzyloxycarbonyl-D-phenylglycinyl-R, S-3- (3- pyridoxy) pyrrolidine D-Phenylglycinyl-4- (3 -pyridoxy) piperidine Benzyloxycarbonyl-D-phenylglycinyl-4- (3-pyridoxy) piperidine (l.lδg 2.64mmol) was dissolved in ethanol (120ml) containing Pd/C 10% (lOOmg) and acetic acid (0.3ml) and hydrogenated at atmospheric pressure for 8h - (incomplete by tic) . The catalyst was removed by filtration and the solution evaporated to an oil. The oil was re-hydrogenated as before. The catalyst was removed by filtration and the solvent evaporated in vacuo to an oil which was taken up in dilute hydrochloric acid. The aqueous solution was washed with dichloromethane and then basified with solid sodium bicarbonate. Extraction with chloroform, drying (MgSθ 4 ) and evaporation of the solvent in vacuo gave D-phenylglycinyl-4- (3-pyridoxy) piperidine, (331mg 40%) . Nmr D-phenylglycinyl-R, S-3- (3-pyridoxy) pyrrolidine In a similar manner D-phenylglycinyl-R, S-3- (3- pyridoxy) pyrrolidine was prepared from benzyloxycarbonyl -D- phenylglycinyl-R, S-3- (3-pyridoxy) pyrrolidine by hydrogenation over Pd/C in ethanol. Nmr. Example 138. 1- (Indole-6-carbonyl-D-phenylglycinyl) -4- (3- pyridoxy) piperidine A mixture of EDCI (169mg 0.88mmol), HOAt (120mg 0.88mmol) and indole-6-carboxylic acid (142mg 0.88mmol) in DMF (5ml) was stirred for 2min and then added to a solution of D- phenylglycinyl -4- (3-pyridoxy) piperidine (229mg 0.735mmol) and triethylamine (89mg 0.88mmol) in DMF (20ml) . The mixture was stirred at room temperature for 3h and excess solvent removed in vacuo. The residue was taken up in ethyl acetate (150ml) and washed with sat. sodium bicarbonate (50ml) . The solution was dried (MgS04) , evaporated and the residue purified by flash chromatography (Siθ2 ethyl acetate: methanol 0% - 5%) to give 1- ( indole-6-carbonyl -D- phenylglycinyl) -4- (3-pyridoxy) piperidine (122mg 41%) Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 10.8min. LCMS M+l 455 Nmr The following were prepared in a similar manner: Example 139. 1- (3-Chloroindole-6-carbonyl-D-phenylglycinyl) -4- (3- pyridoxy) piperidine From D-phenylglycinyl-4- (3 -pyridoxy) piperidine and 3-chloro- 6-indolecarboxylic acid: Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt 11.95min LMCS M+l 489 Nmr Example 140. 1- (Indole-6-carbonyl-D-phenylglycinyl) -3- (R,S) - (3- pyridoxy) pyrrolidine From D-phenylglycinyl-R, S-3- (3 -pyridoxy) pyrrolidine and 6- indolecarboxylic acid. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 6.4min. LCMS M+l 441 Nmr (mixture of diastereomers) . Example 141. 1- (3-Chloroindole-6-carbonyl-D-phenylglycinyl) -3- (R,S) - (3- pyridoxy) pyrrolidine From D-phenylglycinyl-R, S-3- (3-pyridoxy) pyrrolidine and 3- chloro-6-indolecarboxylic acid. Hplc (Luna C18, Gradient3 , water/acetonitrile/TFA), rt, 7.2min. LCMS M+l 475 Nmr (mixture of diastereomers) . Example 142. 1- (3-Methylindole-6-carbonyl-D-phenylglycinyl) -3- (R,S) - (3- pyridoxy) pyrrolidine From D-phenylglycinyl-R, S-3- (3-pyridoxy) pyrrolidine and 3- methyl-6-indolecarboxylic acid. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 6.84 and 7. Omin. ' LCMS M+l 455 Nmr (mixture of diastereomers) . Example 143. (R) -2- (1 ' - (3-Chloroindole-6-carboxamido)benzyl) -4- methoxyphenyl-1, 3-thiazole (R) -2- (1' -benzyloxycarbonylamidobenzyl) -4-methoxyphenyl-l, 3- thiazole To a solution of benzyloxycarbonyl-D-phenylglycine thioamide (lg, 3.33mmol.) in acetone (25ml) was added α-bromo-4- methoxyacetophenone (0.76g, 3.32mmol) and the mixture stirred at room temperature for 30min. Chloroform (25ml) and sat. aqueous sodium hydrogen carbonate (30ml) were added and the organic solution separated, dried (MgS04) and evaporated in vacuo . The residue was dissolved in dichloromethane (30ml) and pyridine (0.5ml, 6.18mmol) and trifluoroacetic anhydride (0.5ml, 3.54mmol) were added. The mixture was stirred at room temperature until complete by tic (Siθ2 dichloromethane - lh.), washed with 5% hydrochloric acid, dried ( gS0 ) and evaporated in vacuo . Flash chromatography of the residue (0.87g). (Siθ2 - dichloromethane) gave (R) -2- (1 ' -benzyloxycarbonylamidobenzyl) -4-methoxyphenyl-l, 3-thiazole (0.74g 1.72mmol . 52%) Nmr: CDC1 3 7.85(2H, d) , 7.3-7.5 (11H, m) , 6.95 (2H, d) , 6.44 (0.5H, bd) , 6.16 (0.5H, bd) , 5.02-5.22 2H, m) , 3.83 (3H. m) . (R) -2- (l 1 -aminobenzyl) -4-methoxyphenyl-l, 3-thiazole (R) -2- (1' -Benzyloxycarbonylamidobenzyl) -4-methoxyphenyl-l, 3- thiazole (0.70g, 1.63mmol) was dissolved in acetic acid (50ml) and HBr in acetic acid (25ml) added. The mixture was heated in a 50°C oil bath for 2h when no starting material remained by tic (Siθ2 30% ether in dichloromethane) . The mixture was evaporated in vacuo, basified with sat. aqueous sodium hydrogen carbonate and extracted with ethyl acetate (x3) . The organic solution was dried (MgS04) and evaporated in vacuo . Flash chromatography (Siθ2 dichloromethane then 30% ether in dichloromethane) gave (R) -2- (1 ' -aminobenzyl) -4- methoxyphenyl-1, 3-thiazole (172mg, 36%) Nmr: CDC1 3 7.7 (2H, d) , 7.5 (2H, d) , 7.17-7.4 (3H, m) , 6.85 (2H, d) , 3.76 (3H, s) (R) -2- (1 ' - (3-Chloroindole-6-carboxamido)benzyl) -4- methoxyphenyl-1, 3-thiazole (R) -2- (1 ' -Aminobenzyl) -4-methoxyphenyl-l, 3-thiazole (80mg, 0.27mmol) was coupled to 3-chloroindolecarboxylic acid using EDC/HOAt to give: (R) -2- (1 ' - (3-Chloroindole-6- carboxamido) benzyl) -4-methoxyphenyl-l, 3-thiazole (49%) Hplc (Luna C18 Gradient3) rt 17.2min. LCMS M+l 474. Nmr. Examples 144 to 147. The compounds of Examples 144 to 147 were prepared by coupling to the appropriate carboxylic acid to D- phenylglycinyl-4,4 ' - (1 ' -methylbispiperidine) using EDC and HOAt as described previously. Example 144. 1- (4-Methylbenzoyl-D-phenylglycinyl) -1' -methyl-4, 4 ' - bispiperidine Hplc (Luna C18 Gradient3) rt 11.2min. LCMS M+l 434. Nmr. Example 145 . 1- (4-Chlorobenzoyl-D-phenylglycinyl) -1' -methyl-4,4 ' - bispiperidine Hplc (Luna C18 Gradient3) rt 11.5min. LCMS M+l 454. Nmr. Example 146. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -1' -methyl-4,4 ' - bispiperidine Hplc (Luna C18 Gradient3) rt 11. lmin. LCMS M+l 450. Nmr. Example 147 1- (3 , 4 -Methylenedioxybenzoyl-D-phenylglycinyl) -1' -methyl-- 4, 4 ' -bispiperidine Hplc (Luna C18 Gradient3) rt 10.65min. LCMS M+l 464. Nmr. Example 148. 1- (Indole-6-carbonyl-D-phenylglycinyl) -1' -isopropyl-4, 4 ' - bispiperidine Benzyloxycarbonyl-D-phenylglycinyl-4,4 ' - (1' -bispiperidine) Benzyloxycarbonyl-D-phenylglycinyl— 1' -isopropyl-4, 4' - bispiperidine D-phenylglycinyl-1' -isopropyl-4, 4 ' -bispiperidine 1- (Indole-6-carbonyl-D-phenylglycinyl)- 1' -isopropyl-4, 4 ' - bispiperidine Prepared by coupling the appropriate carboxylic acid to D- phenylglycinyl-4 , 4 ' - (1 ' - (2 ' ' -propyl) bispiperidine) . Hplc (Luna C18 Gradient3) rt 11.46min. LCMS M+l 487. Nmr. Examples 149 to 154. The compounds of Examples 149 to 154 were prepared by coupling Boc-D-4-carboxamidophenylglycine to the appropriate amine with EDCI/HOAt, deprotection with TFA/DCM and coupling to 3 -amino-4 -chlorobenzoic acid with EDCI/HOAt as previously described. Example 149. 2- (3-Amino-4-chlorobenzoyl-D-4-carboxamidophenylglycinyl) - 1,2,3,4-tetrahydroisoquinoline Hplc (Luna C18 Gradient3) rt 13.15min. LCMS M+l 463. Nmr. Example 150. 1- (3 -Amino-4-chlorobenzoyl-D-4 -carboxamidophenyl- glycinyl) -4-benzylpiperazine Hplc (Luna C18 Gradient3) rt 11.4min. LCMS M+l 512. Nmr. Example 151. 1- (3-Amino-4-chlorobenzoyl-D-4-carboxamidophenylglycinyl) -4- (2 -methylthiophenyl) piperazine Hplc (Luna C18 Gradient3) rt 14.3min. LCMS M+l 539. Nmr. Example 152. 1- (3 -Amino-4-chlorobenzoyl-D-4-carboxamidophenyl- glycinyl) -4- (2 -phenylethyl) piperazine Hplc (Luna C18 Gradient3) rt 11. lmin. LCMS M+l 521. Nmr. Example 153. 1- (3 -Amino-4 -chlorobenzoyl-D-4-carboxamidophenyl- glycinyl) -4-benzoylpiperidine Hplc (Luna C18 Gradient3) rt 12.8min. LCMS M+l 520. Nmr. Example 154. 1- (3 -Amino-4 -chlorobenzoyl-D-4-carboxamidophenyl- glycinyl) -4- (2 -ethylphenyl) piperazine Hplc (Luna C18 Gradient3) rt 13.9min. LCMS M+l 521. Nmr. Example 155. 1- (3 -Methoxyindole-6-carbonyl-D-phenylglycinyl) -1' - methyl-4,4 ' -bispiperidine Methyl l-acetyl-3-formylindole-6-carboxylate A suspension of methyl 3-formylindole-6-carboxylate (lg, 4.93 mmol) in acetic anhydride (10ml) was refluxed for 2 h. The acetic anhydride was removed under reduced pressure to afford a pinkish solid (1.2g, 100%) that was used without further purification. X H NMR (CDC1 3 ) 2.7 (3H, s) , 3.9 (3H, s) , 8.05 (IH, d) , 8.15 (IH, s) , 8.25 (IH, d) , 9.0 (IH, s) , 10.1 (IH, s) ; LCMS M+H 246. Methyl l-acetyl-2, 3-dihydroindol-3-one-6-carboxylate This was prepared from methyl l-acetyl-3-formylindole-6- carboxylate (1.03g, 4.20 mmol) using the method of Merour et al . ( Synthesis, 1994, 411) to yield the formate (680 mg) . The formate was dissolved in THF (50ml) and treated with sat. NaHCθ3 solution (10ml). After 15 min. the reaction mixture was extracted with ethyl acetate, washed with water, dried and concentrated to give the ketone (574mg) . iH NMR (CDC1 3 ) 2.3 (3H, br.), 3.9 (3H, s) , 4.3 (2H, s) , 7.75 (IH, d) , 7.85 (IH, d) , 9.1 (IH, br . ) ; LCMS M+H 234. Methyl 1-acetyl-3 -methoxyindole-6 -carboxylate Methyl l-acetyl-2 , 3 -dihydroindol-3 -one-6-carboxylate (233mg, 1 mmol) , trimethyl orthoformate (10ml) and p-toluene sulphonic acid (20 mg) were heated under reflux for 3 h. in methanol (10ml) . The reaction mixture was concentrated under reduced pressure, poured into water and extracted with chloroform. After drying and evaporation, the product was purified by prep hplc; H NMR (CD3CN) 2.56 (3H, s) , 3.93 (3H, s) , 3.97 (3H, s) , 7.25 (IH, s) , 7.62 (IH, d) , 7.90 (IH, d) , 9.0 (IH, br.); LCMS M+H 248. 3 -Methoxyindole-6-carboxylic acid To a solution of methyl l-acetyl-3-methoxyindole-6- carboxylate (74 mg, 0.3 mmol) in THF (10ml) and water (2ml) was added lithium hydroxide hydrate (63 mg, 1.5 mmol) . The reaction mixture was warmed to 50°C and stirred for 3 h. The THF was removed under reduced pressure and the pH of the aqueous phase adjusted to 3. Extraction of the aqueous layer with ethyl acetate, drying and concentration gave the acid (50 mg, 87%); X H NMR (CD3CN) 3.75 (3H, s) , 3.97 (3H, s) , 6.9 ( IH , s ) , 7 . 45 ( IH , d) , 7 . 55 ( IH , d) , 8 . 2 ( IH , s ) ; LCMS M+H 192 . 1- (3-Methoxyindole-6-carbonyl-D-phenylglycinyl) -4,4 ' - (l 1 - methylbispiperidine) Prepared by coupling to D-phenylglycinyl -4 , 4 ' - (1 ' - methylbispiperidine) using EDC and HOAt as described previously. Hplc (Luna C18, Gradient3) rt 8.35min. LCMS M+l 489 Nmr. Example 156. 1- (3-Amino-4-chlorobenzoyl-D-cyclohexylglycinyl) -4- (4- fluoro-2 -methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradient3, water/acetonitrile/TFA) rt 15.37min. LCMS M+l 551 Example 157. 1- (3-Amino-4-chlorobenzoyl-D,L-l-napthylglycinyl) -4- (4- fluoro-2 -methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradient3, water/acetonitrile/TFA) rt 15.69min. LCMS M+l 595 Example 158. 1- (3-Chloroindole-6-carbonyl-D,L- (2 -methylthiazol-4- yl) glycinyl) -1" " -methyl-4,4" -bispiperidine Ethyl oximinoacetoacetate This was prepared from ethyl acetoacetate (lO.OOg) using the method of Fischer ( Organic Synthesis Coll . Vol . 3 , 513-516) to yield the titled compound (12.45g); H NMR (CDC1 3 ) 1.25 (3H, t), 2.35 (3H, s), 4.3 (2H, q) , 8.8 (IH, br . ) . Ethy1-γ-chloro-α-oximinoacetoacetate This was prepared from ethyl oximinoacetoacetate (1.73g) using the method of Hatanaka et al . { Journal of Medicinal Chemistry, 1973, 16(9), 978-984) to yield the titled compound (1.44g); ! H NMR (CDC1 3 ) 1.25 (3H, t) , 4.3 (2H, q) , 4.55 (2H, s) , 9.45 (IH, s), contains 20% starting material by NMR. Ethyl-α-oximino-2 -methylthiazole-4 -acetate This was prepared from ethyl -γ-chloro-α-oximinoacetoacetate (1.44g) using the method of Hatanaka et al . (Journal of Medicinal Chemistry, 1973, 16(9), 978-984) to yield the titled compound (0.64g); *H NMR (CDC1 3 ) 1.35 (3H, t) , 2.7 (3H, s), 4.35 (2H, q) , 8.2 (IH, s) . D, L- (2-methylthiazol-4-yl) glycine ethyl ester This was prepared from ethyl-α-oximino-2-methylthiazole-4- acetate (0.62g) using the method of Hatanaka et al . ( Journal of Medicinal Chemistry, 1973, 16(9), 978-984) to yield the titled compound (0.40g); "H NMR (CDC1 3 ) 1.15 (3H, t) , 1.95 (2H, br.), 2.6 (3H, s) , 4.15 (2H, m) , 4.65 (IH, s) , 6.95 (IH, s) . N-Boc-D,L- (2 -methylthiazol-4-yl) glycine ethyl ester To a solution of D, L- (2-methylthiazol-4-yl) glycine ethyl ester (0.397g, 1.982 mmol) in tetrahydrofuran (20 cm 3 ), was added di- ert-butyldicarbonate (0.475g, 2.180 mmol) and triethylamine (0.304 cm 3 , 2.180 mmol). This was allowed to stir for 1 hour and the solution concentrated in vacuo. The oil was taken up in ethyl acetate (c.a. 50 cm 3 ) washed with 0.5% hydrochloric acid solution (c.a. 20 cm 3 ), and saturated sodium bicarbonate solution (c.a. 20 cm 3 ). This was then dried over magnesium sulphate and concentrated in vacuo to yield a yellow oil (0.654g, 2.177 mmol) [-100% yield]; X H NMR (CDC1 3 ) 1.1 (3H, s) , 1.35 (9H, s) , 2.6 (3H, s), 4.15 (3H, m) , 5.3 (IH, d) , 5.7 (IH, s) , 7.0 (IH, s) . N-Boc-D,L- (2 -methylthiazol-4-yl) glycine To a solution of N-Boc-D,L- (2-methylthiazol-4-yl) glycine ethyl ester (0.595g, 1.982 mmol) in methanol (c.a. 15 cm 3 ), was added 2M sodium hydroxide (1.98 cm 3 , 3.964 mmol), and allowed to stir for 30 minutes. The solution was concentrated in vacuo and taken up in water (c.a. 50 cm 3 ) . The aqueous solution was washed with ethyl acetate (c.a. 30 cm 3 ) , and then acidified to pH 2 with 5% hydrochloric acid solution (c.a. 50 cm 3 ) . The product was extracted with ethyl acetate (c.a. 3x60 cm 3 ), dried over magnesium sulphate, and concentrated in vacuo to yield a pale yellow oil (0.645g, 2.368 mmol) [-100% yield]; 'H NMR (CDC1 3 ) 1.35 (9H, s) , 2.6 (3H, s) , 5.4 (IH, d) , 5.9 (IH, s) , 7.1 (IH, s) . 1- (N-Boc-D,L- (2-methylthiazol-4-yl) glycinyl) 1"-methyl-4,4"- bispiperidine Prepared by coupling N-Boc-D, L- (2-methylthiazol-4-yl) - glycine to 4 , 4 "- (1" -methylbispiperidine) di-HCl salt using EDC and HOAt as described previously; X H NMR (CDC1 3 ) 0.5-1.3 (10H, br.), 1.35 (9H, s) , 1.4-1.85 (6H, br.), 2.2 (3H, d) , 2.6 (3H, s) , 3.75-4.0 (IH, br.), 4.55 (IH, br . ) , 5.7 (IH, d) , 6.1 (IH, d) , 6.95 (IH, d) 1- (D,L- (2-Methylthiazol-4-yl) glycinyl) - 1""-methyl-4, 4"- bispiperidine Prepared from 1- (N-Boc-D, L- (2-methylthiazol-4-yl) glycinyl) 1" -methyl -4,4"- bispiperidine using DCM/TFA deprotection as described previously; X H NMR (CDC1 3 ) 0.9-1.8 (10H, br.), 2.1- 2.3 (2H, br.), 2.45 (3H, br . ) , 2.6 (3H, s) , 3.1-3.4 (3H, br.), 4.6 (IH, br.), 4.95 (IH, s) , 6.85 (IH, d) . 1- (3-Chloroindole-6-carbonyl- D,L- (2-Methylthiazol-4- yl) glycinyl) - 1" -methyl-4,4" -bispiperidine Prepared by coupling 1- (D, L- (2-methylthiazol-4-yl) - glycinyl)- 1" -methyl- , 4" -bispiperidine to 3-chloroindole-6- carboxylic acid using EDC and HOAt as described previously; X H NMR (CDC1 3 ) 0.5-1.9 (12H, br . ) , 2.4 (2H, br . ) , 2.55 (3H, s) , 2.65 (3H, s) , 3.5 (2H, br . ) , 4.1 (IH, br.), 4.55 (IH, br.), 6.15 (IH, d) , 7.15 (IH, d) , 7.5 (2H, br.), 7.8-8.1 (2H, br.), 8.9-9.25 (IH, br.), 12.2-12.6 (IH, br. d) ; HPLC (Luna C18, Gradient3) rt 8.75min; LCMS M+l 514. Example 159. 1- (3-Chloroindole-6-carbonyl-D,L-4-thiazolylglycinyl) - 1"- methyl-4 , 4 " -bispiperidine Ethyl-α-oximino-thiazole-4-acetate To a 2 necked r.b. flask (100 cm 3 ) with ethanol thermometer, concentrated sulphuric acid (25 cm 3 ) was added and cooled to 0°C with stirring. To this solution, was added the ethyl-α- oximino-2-aminothiazole-4-acetate (5.00g, 23.231 mmol). Water (10 cm 3 ) was then added and cooled to -10°C. A solution of sodium nitrite (1.683g, 24.393 mmol) in water (5 cm 3 ) was then added slowly over an hour keeping the temperature below -5°C. To a separate r.b. flask (500 cm 3 ) , water (180 cm 3 ) was added and cooled to 3°C. The reaction solution was poured on to the cold water with stirring and then cooled to -5°C. To this solution, 50% hypophosphoric acid (90 cm 3 ) was added dropwise over 10 minutes keeping the temperature at -5°C. The solution was allowed to warm to room temperature and stirred overnight. The product was extracted with diethyl ether ( c . a . 3x150 cm 3 ) and washed with water. The ether layer was concentrated in vacuo and treated to flash chromatography (50% ethyl acetate/n-hexane) to yield a orange oil upon concentration in vacuo (0.60g, 3.00 mmol) [13% yield]; H NMR (CDC1 3 ) 1.35 (3H, m) , 4.35 (2H, m) , 8.4 (IH, s) , 8.9 (IH, s) , 14.4 (IH, s) . D,L-4-thiazolylglycine ethyl ester This was prepared from ethyl-α-oximino-thiazole-4-acetate (0.60g) using the method of Hatanaka et al . ( Journal of Medicinal Chemistry, 1973, 16(9), 978-984) to yield the titled compound (0.46g); *H NMR (CDC1 3 ) 1.25 (3H, t) , 1.8-2.3 (2H, br.), 4.1 (2H, m) , 4.75 (IH, s) , 7.25 (IH, d) , 8.7 (IH, d) . N-Boc-D, L-4- thiazolylglycine ethyl ester To a solution of D, L-4-thiazolylglycine ethyl ester (0.460g, 2.470 mmol) in tetrahydrofuran (20 cm 3 ), was added di-tert- butyldicarbonate (0.530g, 2.470 mmol) and triethylamine (0.344 cm 3 , 2.470 mmol). This was allowed to stir for 1 hour and the solution concentrated in vacuo. The oil was taken up in ethyl acetate (c.a. 50 cm 3 ) washed with 0.5% hydrochloric acid solution (c.a. 20 cm 3 ) , and saturated sodium bicarbonate solution (c.a. 20 cm 3 ) . This was then dried over magnesium sulphate and concentrated in vacuo to yield an orange oil (0.709g, 2. ll mmol) [-100% yield]; H NMR (CDC1 3 ) 1.15 (3H, t) , 1.35 (9H, s), 4.1 (2H, m) , 5.45 (IH, d) , 5.75 (IH, d) , 7.3 (IH, d) , 8.7 (IH, d) . N-Boc-D, L-4- thiazolylglycine To a solution of N-Boc-D, L-4- thiazolylglycine ethyl ester (0.700g, 2.470 mmol) in methanol (c.a. 15 cm 3 ), was added 2M sodium hydroxide (2.47 cm 3 , 4.940 mmol) and allowed to stir for 90 minutes. The solution was concentrated in vacuo and taken up in water (c.a. 20 cm 3 ) . The aqueous solution was washed with ethyl acetate (c.a. 20 cm 3 ), and then acidified to pH 2 with 5% hydrochloric acid solution (c.a. 50 cm 3 ) . The product was extracted with ethyl acetate (c.a. 3x30 cm 3 ) , dried over magnesium sulphate, and concentrated in vacuo to yield a pale yellow oil (0.582g, 2.254 mmol) [91% yield]; X H NMR (CDC1 3 ) 1.35 (9H, s), 5.5 (IH, d) , 5.8 (IH, d) , 7 . 35 ( IH , d) , 8 . 75 ( IH , d) , 9 . 8 - 10 . 2 ( IH , br . ) . 1- (N-Boc-D, L-4- thiazolylglycinyl) - 1" -methyl-4, 4"- bispiperidine Prepared by coupling N-Boc-D, L-4- thiazolylglycine to 4 , 4"- (1" -methylbispiperidine) di-HCl salt using EDC and HOAt as described previously; X H NMR (CDC1 3 ) 0.8-1.25 (10H, br.), 1.35 (9H, m) , 1.7 (6H, br.), 2.0 (6H, m) , 2.4 (3H, br.), 3.1 (2H, br.), 3.7 (IH, d) , 4.6 (IH, d) , 5.8 (IH, d) , 6.0 (IH, br.), 7.25 (IH, IH, br.), 8.65 (IH, m) . 1- (D, L-4 -Thiazolylglycinyl) - 1"-methyl-4, 4"- bispiperidine Prepared from 1- (N-Boc-D, L-4- thiazolylglycinyl)- 1" -methyl- 4,4"- bispiperidine using DCM/TFA deprotection as described previously. The product was purified by prep HPLC; LCMS M+l 323. 1- (3 -Chloroindole-6-carbonyl- D,L- thiazol-4-ylglycinyl- 1"- methyl-4 , 4 " -bispiperidine Prepared by coupling 1- (D, L-4 -Thiazolylglycinyl) - l"-methyl- 4,4"- bispiperidine to 3-chloroindole-6-carboxylic acid using EDC and HOAt as described previously; 1 H NMR (CD 3 CN) 0.5-2.0 (10H, br.), 2.5 (2H, m) , 2.8 (3H, br.), 3.1 (2H, m) , 3.5 (2H, br.), 4.2 (IH, d) , 4.6 (IH, d) , 6.4 (IH, m) , 7.5 (IH, br.), 7.8 (2H, br.), 8.15 (2H, br.), 9.05 (IH, br.), 9.9 (IH, br.); HPLC (Luna C18, Gradient3) rt 6.69min ; LCMS M+l 500. Preparation of starting materials: Boc-R-4- (carboxymethyl) phenylglycine R-4-Hydroxyphenylglycine methyl ester hydrochloride. To a dry 250ml three necked round bottom flask, equipped with a low temperature thermometer, a septum for nitrogen coverage and another for introduction of thionyl chloride by syringe, was added R-4-hydroxyphenylglycine (12.5g) and dry methanol (24ml) . The mixture was stirred (magnetic stirrer) and cooled to an internal temperature of -20°C using cardice/acetone . Using a syringe, thionyl chloride was added dropwise to the cooled mixture over a period of lOmin. (Care: the reaction of thionyl chloride with methanol is very exothermic and rate of addition should be such that the thionyl chloride is efficiently stirred into the mixture and that the temperature does not rise above -20°C. Once the addition was complete the mixture was allowed to warm to room temperature overnight (16-18hr) . Dry ether (150ml) was added and the white ppt. that formed was filtered off, washed with a little more ether and dried. Yield 15.5g 95%. Nmr. Boc-R-4-Hydroxyphenylglycine methyl ester hydrochloride To a stirred mixture of R-4-hydroxyphenylglycine methyl ester hydrochloride 14g and sodium bicarbonate 11.7g in tetrahydrofuran (THF) 150ml and water 50ml, was added in one portion, di- t-butyl dicarbonate 15.9g. The mixture was stirred rapidly to allow thorough mixing for 4h. Hexane (75ml) was added and the organic layer separated and washed with sat. sodium bicarbonate solution, then brine and then dried with magnesium sulphate. The drying agents was filtered off and washed with a little THF and evaporated to dryness, finishing with a high vacuum pump to remove the last traces of di- t-butyl dicarbonate. Yield 19.7g 96%. Nmr. Boc-R-4- (trifluoro ethanesulphonyloxy) phenylglycine methyl ester hydrochloride To a stirred solution of Boc-R-4-hydroxyphenylglycine methyl ester 19g in dichloromethane 400ml was added 2,6-lutidine 9.44ml and 4-dimethylaminopyridine 1.65g and the mixture cooled in an ice bath. Trifluoromethanane-sulphonic anhydride 13.74ml was added over a period of 5min and then the reaction left to warm to room temperature over 4h. The organic solution was washed with water, 2 x 150ml, IN HCl 2 x 150ml and the saturated sodium bicarbonate 150ml. The organics were dried with magnesium sulphate and then evaporated to and oil. The mixture was purified using flash chromatography (Si0 2 250g eluting with 1:1 hexane/dichloromethane and then neat dichloromethane) . Pure product fractions were combined and evaporated, finishing with a high vacuum pump to remove all traces of solvent, to give a white solid, 19g 77%. Nmr. Boc-R-4- (carboxymethyl) phenylglycine methyl ester. Boc-R-4-trifluoromethanesulphonyloxyphenylglycine methyl ester (15g) , methanol (32.6ml), bis-1,3- diphenylphosphinylpropane (448mg) , palladium (II) acetate (255mg) , triethylamine (10.2ml) and dimethylformamide (72ml) were placed in the glass liner of the Parr reactor and the reactor assembled. The vessel was pressurised to ~10psi with nitrogen and the gas released (repeated five times to remove all oxygen from the system) . Carbon monoxide gas was then carefully introduced (use extreme care -the gas cylinder is pressurised to far beyond the bursting disc pressure of the Parr, ideally use a pressure regulator to reduce the pressure to -lOOpsi) to ~20psi and released three times (into the back of a fume hood) . Carbon monoxide was then added to -lOOpsi and the stirrer started. The vessel was slowly heated to 65°C internal temperature and then stirred at 65°C overnight. (At the early stages more carbon monoxide was added to maintain -lOOpsi) A sample was removed after 18h and examined by tic. When complete, the reaction was cooled to ~30°C, the gas released and the vessel flushed five times with nitrogen as before. The reaction mixture was partitioned between ethyl acetate and water and the organic layer washed with 1M hydrochloric acid and then saturated sodium bicarbonate. The solution was dried with MgS0 4 and evaporated. Flash chromatography of the resulting oil gave the product, pure by tic, 10.6g 90%. Nmr Boc-R-4- (carboxymethyl) phenylglycine. To a solution of Boc-R-4 -carboxymethylphenylglycine methyl ester 692mg in THF 10ml was added a solution of lithium hydroxide hydrate 90mg in water 7ml. The mixture immediately became cloudy and over 15min cleared. After 30min, tic showed the reaction to be complete. Ethyl acetate 20ml and water 20ml were added and the aqueous layer separated. The aqueous solution was acidified with 2M hydrochloric acid and extracted with ethyl acetate (3 x 20ml) . The organic solution was then washed with water x 2 and brine x 2, dried with MgS0 4 and evaporated to give the mono-ester (650mg, 98%), pure by tic. Nmr. Boc-R-4- (carboxybenzyl) phenylglycine methyl ester By the same method as described above, using 27.6g of Boc-R- 4-trifluoromethanesulphonyloxyphenylglycine methyl ester and benzyl alcohol to give the Boc-D-4- (carboxybenzyl) phenylglycine methyl ester 18.7g pure, 70% plus a further 6g of impure material ( the major contaminant is benzyl alcohol) . Nmr Boc-R-4- (carboxamido) phenylglycine methyl ester Boc-R-4- (carboxy) phenylglycine methyl ester Boc-R-4- (carboxybenzyl) henylglycine methyl ester (500mg) was dissolved in THF containing Pd/C 10% (lOOmg) and hydrogenated at latm for 2h. Removal of the catalyst by filtration and evaporation of solvent gave Boc-R-4- (carboxy) phenylglycine methyl ester (330mg, 87%) . Nmr. Boc-R-4- (carboxamido) phenylglycine methyl ester To a solution of Boc-R-4- (carboxy) phenylglycine methyl ester (3.5g) in DMF 30ml was added EDCI (2.60g 1.36mmol) and HOBt (1.4g 10.4mmol) and the mixture stirred for lOmin before cooling in a ice bath and bubbling in ammonia gas for 5min. The mixture was stirred for 2h at room temperature ansd then diluted with ehtyl acetate and washed with water. The aqueous solution was extracted with a little ethyl acetate and the combined organics washed with brine. The organic solution was evaporated to an oil which was purified by flash chromatography (Si0 2 - dichloromethane/ ethyl acetate 0 - 25%) to give Boc-R-4- (carboxamido) phenylglycine methyl ester (1.7g 48%) . Nmr. Boc-R-4- (methylcarboxamido) henylglycine methyl ester Was prepared by a similar method to that descibed above. Nmr Boc-R-4-Methoxyphenylglycine. Boc-R-4-hydroxyphenylglycine methyl ester was converted to Boc-R-4-methoxyphenylglycine using the alkylation method described by Basak et al . (Tetrahedron Lett. 1998, 39 (27), 4883-4886) followed by hydrolysis of the methyl ester with lithium hydroxide in aqueous THF. Nmr Boc-D, -2-chlorophenylglycine 2-Chlorobenzaldehyde (20mmol., 2.252ml) and 2,4 dimethoxybenzylamine (20mmol., 3.004ml) were added together and stirred for 2 hours. DCM (5ml) was added and any water separated and removed. tert-Butyl isonitrile (20mmol., 2.262ml) was added and stirred for lOmins followed by acetic acid (20mmol., 1.145ml). Stirring was continued for 3 days. The reaction mixture was then treated with TFA (30ml) and triethylsilane (5ml) . After 3 hours the mixture was evaporated to dryness, 6M HCl (100ml) added and the whole refluxed overnight at 130°C, stirring rapidly. The mixture was allowed to cool and extracted with EtOAc (50ml x2) the aqueous fraction was evaporated to dryness and treated with 2M NaOH solution. The mixture was extracted with EtOAc (50ml x2) excess boc anhydride (5.2g) in dioxan (20ml) was added to the aqueous fraction and stirred overnight. The mixture was extracted with diethyl ether (100ml x2) acidified to pH 1 (cHCl) and extracted with EtOAc (50ml x2) . The combined organic fractions were washed with water and evaporated to dryness under high vacuo The product Boc -2 -chloro phenylglycine (4.252g, 74.5%) X H nmr (CD3CN/D20) 7.3 (4H, m) ; 5.5 (IH, s) ; 1.3 (9H, s) . MS 286 (M+l) By a similar method the following amino acids were obtained Boc-D, L-3-fluorophenylglycine Η nmr (CD3CN/D20) 7.3 (IH, m) , 7.1(3H, m) ; 5.2 (IH, s) ; 1.3 (9H, s) . MS 270 (M+l) Boc-D, L-4-fluorophenylglycine Η nmr (CD3CN/D20) 7.3 (2H, m) ; 6.9 (2H, m) , 5.0 (IH, s) ; 1.3 (9H, s) . MS 270 (M+l) Boc-D, L-2 -methylphenylglycine X H nmr (CD3CN/D20) 7.3 (4H, m) ; 5.5 (IH, s) ; 2.5 (3H, s) ; 1.3 (9H, s) . MS 266 (M+l) Boc-D,L-3-thienylglycine *H nmr (CD3CN/D20) 7.5 (2H, m) ; 7.1 (IH, d) ; 5.3 (IH, s) ; 1.3 (9H, s) . MS 258 (M+l) Boc-D, L-2-fluorophenylglycine Was obtained by treating D, L-2-fluorophenylglycine (Aldrich) with Boc anhydride (l.leq) and 2M NaOH (leq) in Ethanol. Aqueous work up as described above yielded the protected amino acid. Nmr. These protected aminoacids were then coupled with first an amine and then, after removal of the Boc protecting group, with a carboxylic acid by method 2 to give the following inhibitor examples: Example 160. 1- (4 Methoxybenzoyl-D,L-3-thienylglycinyl) 4- (2- methylsulfonylpheny1) -piperazine Hplc (Luna C18, Gradient3, water/acetonitrile/TFA) rt 10.18 LCMS M+l 514. Nmr. Example 161. 1- (Indol-6-carbonyl-D,L-3-thienylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradient3, water/acetonitrile/TFA) rt 10.44 LCMS M+l 523. Nmr. Example 162. 1- (4 Methoxybenzoyl-D,L-3-fluorophenylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradient3, water/acetonitrile/TFA) rt 10.61 LCMS M+l 526. Nmr. Example 163. 1- (Indol-6-carbonyl-D,L-3-fluorophenylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradient3, water/acetonitrile/TFA) rt 10.88 LCMS M+l 535. Nmr. Example 164. 1- (4 Methoxybenzoyl-D,L-4-fluorophenylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradient3, water/acetonitrile/TFA) rt 10.52 LCMS M+l 526. Nmr. Example 165. 1- (Indol-6-carbonyl-D,L-4-fluorophenylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradients, water/acetonitrile/TFA) rt 10.92 LCMS M+l 535. Nmr. Example 166 . 1- (4 Methoxybenzoyl-D,L-2 -chlorophenylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradients, water/acetonitrile/TFA) rt 10.82 LCMS M+l 542 Nmr. Example 167. 1- (Indol-6-carbonyl-D,L-2-chlorophenylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradients, water/acetonitrile/TFA) rt 10.63 LCMS M+l 551 Nmr. Example 168. 1- (4 Methoxybenzoyl-D,L-2-methylphenylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradient3, water/acetonitrile/TFA) rt 10.69 LCMS M+l 522 Nmr. Example 169. 1- (Indol-6 -carbonyl-D, L-2-methylphenylglycinyl) 4- (2- methylsulfonylphenyl) -piperazine Hplc (Luna C18, Gradients, water/acetonitrile/TFA) rt 10.76 LCMS M+l 531 Nmr. Example 170 . 1- (Indol-6 -carbonyl-D-2-fluorophenylglycinyl) 4- (4 -fluoro - 2 -methylsulfonylphenyl) -piperazine Hplc (Luna 2 C18 3u water/acetonitrile/TFA, gradient = 5- 100%MeCN over 7 min)rt 10.92 LCMS M+l 553 Nmr. Example 171. 1- (Indol-6-carbonyl-D- (4-carboxyphenylglycinyl) - (4- (1- methylpiperidin-4-yl) piperazine) By coupling of Boc-D-4-carboxymethylphenylglycine with 1- (4- (l-methylpiperidin-4-yl) piperazine) using HOAt and EDCI, followed by deprotection (TFA) , coupling to indol-6- carboxylic acid using HOAt and EDCI followed by hydrolysis of the methyl ester with lithium hydroxide. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 6.05min LCMS M+l 504 Nmr. Example 172. 1- (Indol-6-carbonyl-D-phenylglycinyl) -4- (4- hydroxyphenyl) piperazine By coupling of Boc-D-phenylglycine with 1- (4- hydroxyphenyl) piperazine using HOAt and EDCI, followed by deprotection (TFA) and coupling to indol-6-carboxylic acid using HOAt and EDCI . Hplc (Symmetry C8 , Gradients, water/acetonitrile/TFA), rt, 6. Omin LCMS M+l 455 Nmr. Example 173. 1- (3-Chloroindol-6-carbonyl-D-phenylglycinyl) -4- (4- hydroxypheny1) iperazine By coupling of Boc-D-phenylglycine with l-(4- hydroxyphenyl) piperazine using HOAt and EDCI, followed by deprotection (TFA) and coupling to 3-chloroindol-6- carboxylic acid using HOAt and EDCI. Hplc (Symmetry C8, Gradients, water/acetonitrile/TFA), rt, 6.55min LCMS M+l 489 Nmr . Example 174. 1- (4-methoxybenzoyl-D-4-methoxyphenylglycinyl) -4- (2- methy1sulphonylphenyl) piperazine By coupling of Boc-D-4-methoxyphenylglycine with- (2- methylsulphonylphenyl) iperazine using HOAt and EDCI, followed by deprotection (TFA) and coupling to 4- methoxybenzoic acid using HOAt and EDCI . Hplc (Luna C18, Gradients, water/acetonitrile/TFA), rt, 10.4min LCMS M+l 538 Nmr. Example 175 . 1- (5-Fluoroindole-6-carbonyl-D-phenylglycinyl) -1-methyl- 4,4' -bispiperidine. N- (2,2-Dimethoxyethyl) -4-fluoro-3-methoxyaniline To a solution of 4-fluoro-3-methoxyaniline (0.98g 6.9mτnol) in ethanol (20ml) was added glyoxal 1,1-dimethyl acetal (0.89g 8.27mmol). Pd/C 5% (50mg) was added and the mixture hydrogenated. Removal of the catalyst by filtration and evaporation of solvent in vacuo gave N- (2 , 2-dimethoxyethyl) 4-fluoro-3 -methoxyaniline 1.6g NMR LCMS M+l (less MeO) 199 N- (2,2-Dimethoxyethyl) -N-methanesulphonyl-4-fluoro-3- methoxyaniline N- (2, 2-dimethoxyethyl) -4-fluoro-3 -methoxyaniline (1.46g, 6.37mmol) in dichloromethane (20ml) was treated with pyridine (0.5g 6.37mmol) and methanesulphonyl chloride (766mg, 6.69mmol)and the mixture stirred until the reaction was complete by tic. Aqueous work up and removal of solvent in vacuo gave N- (2 , 2-dimethoxyethyl) -N-methanesulphonyl-4- fluoro-3-methoxyaniline 1.91g NMR 5-Fluoro-1-methanesulphonyl-6-methoxyindole To a solution of N- (2 , 2-dimethoxyethyl) -N-methanesulphonyl- 4-fluoro-3-methoxyaniline (1.91g, 0.65mmol) in dry toluene at 0°C under argon, was added slowly a solution of TiCl 4 (0.173g, 0.911mmol) in dry toluene (10ml). The solution was then heated to 70°C for lh. cooled and poured onto ice/sat. sod. bicarbonate solution (20ml) . The organic layer was separated, washed with sat. sod. bicarbonate solution, 0.5% hydrochloric acid (2 x 20ml) and water (2 x20ml) . The solution was dried (MgS0 4 ) and evaporated in vacuo to give 5-fluoro-1-methanesulphonyl-6-methoxyindole ( (0.102g) NMR 5-Fluoro-6-hydroxy-1-methanesulphonylindole To a solution of 5-fluoro-1-methanesulphonyl-6-methoxyindole (0.10g 0.41mmol) in dry dichloromethane (3ml) at -10°C was added a solution of BBr 3 (1M in dichloromethane, 1.23ml) over one minute. The reacture was warmed to room temperature and stirred for 2h and then poured onto ice/lM hydrochloric acid (10ml) . After stirring for 15min the mixture was extracted with ethyl acetate (1 x 50ml, 2x 20ml), dried (MgS0 4 ) and evaporated in vacuo to give 5-fluoro-6-hydroxy- 1-methanesulphonylindole (70mg) NMR 5-Fluoro-1-methanesulphonyl-6-trifluoromethanesulphonyloxy- indole To a solution of 5-fluoro-6-hydroxy-l-methanesulphonylindole (0.57mg, 2.49mmol) in dry dichloromethane (20ml) at 0°C was added pyridine (0.24ml, 2.99mmol) and then trifluoromethanesulphonic anhydride (0.50ml, 2.99mmol) and the mixture stirred for 2h. The reaction mixture was washed with 0.5% hydrochloric acid (2 x50ml), sodium bicarbonate solution (2 x 50ml) and water (50ml) , dried (MgS0 4 ) and filtered through a short pad of silica. Evaporation of solvent in vacuo gave 5-fluoro-l-methanesulphonyl-6- trifluoromethanesulphonyloxy-indole, (0.67g) . NMR Methyl 5-fluoro-1-methanesulphonyl-indol-6-carboxylate, To a solution of 5-fluoro-1-methanesulphonyl-6- trifluoromethanesulphonyloxy-indole, (0.70g 1.94mmol) was added, Pd (II) acetate (14mg) , bis 1,3- diphenylphosphinylpropane (24mg) , dimethylformamide (4ml) and methanol (2ml) and triethylamine (0.54ml) and the mixture stirred for 2 min. Carbon monoxide gas was bubbled in for 15min and then the mixture was heated to 75°C under an atmosphere of carbon monoxide and stirred overnight. After cooling to room temperature the mixture was poured into ethyl acetate (80ml) and washed with 1M hydrochloric acid (50ml), sat. sod. bicarbonate (50ml) and water (50ml). Drying (MgS0 4 ) , evaporation of solvent gave crude product (0.53g) .Purification of a portion (225mg)by flash chromatography (Si0 2 25% ethyl acetate in hexane) gave methyl 5-fluoro-1-methanesulphonyl-indol-6-carboxylate, (173mg) NMR 5-fluoro-1-methanesulphonyl-indol-6-carboxylic acid To a solution of methyl 5-fluoro-1-methanesulphonyl-indol-6- carboxylate (173mg) in THF (15ml) and water (2ml) was added 2M lithium hydroxide solution (3 equiv) and the mixture heated to 50°C for 2h. and then allowed to cool overnight. The solution was concentrated in vacuo, diluted with 2M sodium hydroxide solution (10ml) and washed with ethyl acetate. The aqueous solution was acidified to pH3 with cone, hydrochloric acid and extracted with ethyl acetate (3 x 30ml) . The organic solution was evaporated in vacuo to give 5-fluoro-l-methanesulphonyl-indol-6-carboxylic acid (164mg) - (circa 80% pure) NMR 1- (5-fluoro-l-methanesulphonyl-indol-6-carbonyl-D- phenylglycinyl-4,4 ' - (1' -methylbispiperidine) 5-fluoro-l-methanesulphonyl-indol-6-carboxylic acid (164mg) was coupled to D-phenylglycinyl-4, 4 '- (1 ' - methylbispiperidine) using EDCI/HOAt as previously described to give 1- (5-fluoro-l-methanesulphonyl-indol-6-carbonyl-D- phenylglycinyl-4, '- (1 ' -methylbispiperidine) (lllmg) - (-70% pure) NMR 1- (5-fluoroindol-6-carbonyl-D-phenylglycinyl-4,4 ' - (1' - methylbispiperidine) 1- (5-fluoro-1-methanesulphonyl-indol -6 -carbonyl -D- phenylglycinyl -4 , 4 ' - (1 ' -methylbispiperidine) (lllmg-~70% pure) was refluxed in ethanol (5ml) and sodium hydroxide solution (34mg in 0.34ml) for 2.25h. The mixture was evaporated to dryness, taken up in water (10ml) and extracted with chloroform (60ml) . The organic solution was dried (MgS0 4 ) and evaporated in vacuo and the residue purified by Prep Hplc. To give 1- (5-fluoroindol-6-carbonyl - D-phenylglycinyl-4, 4 '- (1 ' -methylbispiperidine) (19mg) Hplc (Luna C18 Gradient 3) rt 11.37min LCMS M+l 477 NMR Example 176. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (2- pyridoxy) piperidinamide 1-t-Butoxycarbonyl-4- (2 -pyridoxy) piperidine l-t-Butoxycarbonyl-4-piperidinol (5.0g 24.88mmol) in dry dimethylformamide (60ml) was treated with sodium hydride (60% 2.99g 74.75mmol) at room temperature under argon and then with 2-chloropyridine hydrochloride (4.1g 27.33mmol). Then mixture was heated at 80°C overnight. After cooling the reaction was carefully quenched with water (5ml) and then diluted with more water (20ml) and extracted with ethyl acetate (30ml) . The organic solution was washed with sat. sodium bicarbonate, dried (MgS0 4 ) and evaporated to give 1- t-butoxycarbonyl-4- (2 -pyridoxy) piperidine (4.96g 72%) 4- (2 -pyridoxy) piperidine dihydrochloride . 1-t-Butoxycarbonyl-4- (2-pyridoxy) piperidine (6.5g) was treated with a solution of hydrogen chloride in ethyl acetate (110ml) for 7h and the mixture evaporated to give 4- (2 -pyridoxy) piperidine dihydrochloride, (7.4g 90%) 1- (Benzyoxycarbonyl-D-phenylglycinyl) -4- (2- pyridoxy) piperidinamide Benzyloxycarbonyl-D-phenylglycine (3.75g 13.14mmol) was coupled to 4- (2 -pyridoxy) piperidine dihydrochloride (3.0g 11.94mmol) using EDCI (2.52g 13.14g), HOAt (1.79g 13.13mmol) and triethylamine (3.63g 35.87mmol) to give, after work up with ethyl acetate and sodium bicarbonate solution, 1- (benzyoxycarbonyl-D-phenylglycinyl) -4- (2- pyridoxy) iperidinamide, (4.9g 92%) l-D-phenylglycinyl-4- (2-pyridoxy) piperidinamide 1- (Benzyoxycarbonyl-D-phenylglycinyl) -4- (2- pyridoxy) iperidinamide (400mg) was hydrogenated in ethanol with 5% Pd/C overnight. Removal of catalyst and evaporation of solvent gave l-D-phenylglycinyl-4- (2- pyridoxy) piperidinamide (162mg 58%) Using a similar method and the appropriate starting materials the following intermediates were also prepared: 1- (D-phenylglycinyl-4- (4-pyridoxy) piperidinamide 1- (D-phenylglycinyl) -3-R,S- (4-pyridoxy) pyrrolidinamide 1- (D-phenylglycinyl) -3-R,S- (2-pyridoxy) pyrrolidinamide 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (2- pyridoxy) piperidinamide l-D-phenylglycinyl-4- (2-pyridoxy) piperidinamide (162mg 0.52mmol) was treated with triethylamine (58mg 0.573mmol) and p-anisoyl chloride (93mg 0.545mmol) in dry dichloromethane for lh. The reaction mixture was washed with sodium bicarbonate solution and brine, dried (MgS0 4 ) and evaporated to an oil. Flash chromatography gave the product 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (2- pyridoxy) piperidinamide, (60mg 26%) Hplc (Luna C18, Gradients, water/acetonitrile/TFA), rt, 8.94min LCMS M+Na 468 Nmr By a similar method the following compounds were prepared: Example 177. 1- (Indol-6-carbonyl-D-phenylglycinyl) -4- (2- pyridoxy) piperidinamide By the coupling of indol -6 -carboxylic acid and 1-D- phenylglycinyl-4- (2 -pyridoxy) piperidinamide using EDCI and HOAt. LCMS M+l 455 Nmr Example 178. 1- (3-Chloroindol-6-carbonyl-D-phenylglycinyl) -4- (2- pyridoxy) piperidinamide By the coupling of 3 -chloroindol-6 -carboxylic acid and l-D- phenylglycinyl-4- (2 -pyridoxy) piperidinamide using EDCI and HOAt. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 10.29min LCMS M+l 489 Nmr Example 179. 1- (3-Chloroindol-6-carbonyl-D-phenylglycinyl) -4- (4- pyridoxy) piperidinamide By the coupling of 3 -chloroindol-6 -carboxylic acid and l-D- phenylglycinyl-4- (4 -pyridoxy) piperidinamide using EDCI and HOAt. Hplc (Luna C18, Gradients , water/acetonitrile/TFA), rt, 8.16min LCMS M+l 489 Nmr Example 180. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4- pyridoxy) piperidinamide By the coupling of p-anisoyl chloride and l-D-phenylglycinyl-4- (4-pyridoxy) piperidinamide in dichloromethane with triethylamine Hplc (Luna C18, Gradients, water/acetonitrile/TFA), rt, 7. Omin LCMS M+l 446 Nmr Example 181. 1- (Indol-6-carbonyl-D-phenylglycinyl) -4- (4- pyridoxy) piperidinamide By the coupling of indol-6-carboxylic acid and l-D- phenylglycinyl-4- (4 -pyridoxy) piperidinamide with EDCI and HOAt. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt , 7.08min LCMS M+l 455 Nmr Example 182. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -3-R,S- (4- pyridoxy) yrrolidinamide By the coupling of p-anisoyl chloride and 1- (D- phenylglycinyl) -3-R,S- (4 -pyridoxy) pyrrolidinamide in dichloromethane with triethylamine LCMS M+l 432 Nmr Example 183. 1- (Indol-6-carbonyl-D-phenylglycinyl) -3-R,S- (4- pyridoxy)pyrrolidinamide By the coupling indol -6-carboxylic acid and 1- (D- phenylglycinyl) -3 -R, S- (4 -pyridoxy) pyrrolidinamide with EDCI and HOAt LCMS M+l 441 Nmr Example 184. 1- (3-Chloroindol-6-carbonyl-D-phenylglycinyl) -3-R,S- (4- pyridoxy) pyrrolidinamide By the coupling 3-chloroindol-6-carboxylic acid and 1- (D- phenylglycinyl) -3-R, S- (4-pyridoxy) pyrrolidinamide with EDCI and HOAt LCMS M+l 475 Nmr Example 185. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -3-R,S- (2- pyridoxy) pyrrolidinamide By the coupling of p-anisoyl chloride and 1- (D-phenylglycinyl) -3-R,S- (2 -pyridoxy) pyrrolidinamide in dichloromethane with triethylamine LCMS M+l 432 Nmr Example 186. 1- (3-Chloroindol-6-carbonyl-D-phenylglycinyl) -3-R,S- (2- pyridoxy) pyrrolidinamide By the coupling 3-chloroindol-6-carboxylic acid and 1- (D- phenylglycinyl) -3-R, S- (2 -pyridoxy) pyrrolidinamide with EDCI and HOAt LCMS M+l 475 Nmr Example 187. 1- (Indol-6-carbonyl-D-phenylglycinyl) -3-R,S- (2- pyridoxy) pyrrolidinamide By the coupling indol-6 -carboxylic acid and 1- (D-phenyl- glycinyl) -3-R, S- (2 -pyridoxy) pyrrolidinamide with EDCI and HOAt LCMS M+l 441 Nmr Example 188. 1- (4-methoxybenzoyl-D-4-hydroxyphenylglycinyl) -4- (2- methylsulphonylphenyl) piperazine By coupling of Boc-D-4-hydroxyphenylglycine with- (2- methylsulphonylphenyl) piperazine using HOAt and EDCI, followed by deprotection (TFA) and coupling to 4- methoxybenzoic acid using HOAt and EDCI. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 9. lmin LCMS M+l 524 Nmr . Example 189. 1- (Indol-6-carbonyl-D-4-hydroxyphenylglycinyl) -4- (2- methylsulphonylphenyl) piperazine By coupling of Boc-D-4-hydroxyphenylglycine with- (2- methy1sulphonylphenyl) piperazine using HOAt and EDCI, followed by deprotection (TFA) and coupling to 6-indole carboxylic acid using HOAt and EDCI. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt, 9. Omin LCMS M+l 533 Nmr. Example 190. 1- (Indol-6-carbonyl-D-4-hydroxyphenylglycinyl) - l"-methyl- 4,4" -bispiperidine By coupling of Boc-D-4-hydroxyphenylglycine with 4,4"- (1"- methylbispiperidine) di-HCl salt using HOAt and EDCI, followed by deprotection (TFA) and coupling to 6-indole carboxylic acid using HOAt and EDCI. Hplc (Luna C18, Gradients , water/acetonitrile/TFA), rt, 6.8min LCMS M+l 475 Nmr. Example 191. 1- (3-Chloroindol-6-carbonyl-D-4-hydroxyphenylglycinyl) - 1 " methyl-4, 4 "-bispiperidine By coupling of Boc-D-4-hydroxyphenylglycine with 4,4"- (1"- methylbispiperidine) di-HCl salt using HOAt and EDCI, followed by deprotection (TFA) and coupling to 3- chloroindole-6-carboxylic acid using HOAt and EDCI. Hplc (Luna C18, Gradient3, water/acetonitrile/TFA), rt , 7.3min LCMS M+l 509 Nmr . In the following examples the following additional abbreviations and meanings are included: CI-MS, chemical ionization mass spectrum; DMSO, dimethyl sulfoxide (perdeuterated if for NMR) ; EtOAc, ethyl acetate; EtOH, ethanol; IS-MS, ion spray mass spectrum; RPHPLC, reverse phase HPLC; SCX, strong cation exchange resin; THF, tetrahydrofuran; TLC, thin layer chromatography with Rf as relative mobility; Reagents were obtained from a variety of commercial sources. IR means an infrared spectrum was obtained. i NMR, IH-NMR, or IH NMR means a proton magnetic resonance spectrum was obtained. In general in this specification, "D-" or "R-" in the name of a product indicates the product was made beginning with a chiral starting material, for example D-phenylglycine; however, racemization may have occurred, and the enantiomeric purity may not have been determined. Examples 201-210 Preparation of Starting Materials 4- [ (Benzyloxycarbonyl-D-phenylglycinyl) aminomethyl] -1-Boc- piperidine Using Coupling Method C, benzyloxycarbonyl-D-phenylglycine (10.4 g, 36.5 mmol) and 4-aminomethyl-1-Boc-piperidine (7.3 g, 36.5 mmol) afforded, after purification by column chromatography (Siθ2: 4:1 to 3:2 hexanes : EtOAc) , 10.2 g (58%) of the title compound. iNMR IS-MS, m/e 482 (M+l) . 4- [ (D-Phenylglycinyl) aminomethyl] -1-Boc-piperidine (Deprotection Method C) A solution of 4- [ (benzyloxycarbonyl- D-phenylglycinyl) aminomethyl] -1-Boc-piperidine (9.00 g, 18.7 mmol) and 10% palladium on carbon (2.34 g) in EtOAc (80 mL) :EtOH (200 mL) was placed under an atmosphere of hydrogen gas (balloon) . After 16 h, the mixture was filtered and concentrated affording 6.31 g (98%) of the title compound, which was used without further purification. iNMR IS-MS, m/e 348 (M+l) . 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1-Boc- piperidine (Acylation Method C) A solution of 4- [ (D-phenylglycinyl) - aminomethyl] -1-Boc-piperidine (2.38 g, 6.88 mmol) and pyridine (8 mL) in methylene chloride was treated with 4-methoxybenzoyl chloride (1.76 g, 10.3 mmol) in methylene chloride (prepared by treatment of 4 -methoxy benzoic acid with excess oxalyl chloride in methylene chloride followed by concentration) . After 2 days, the mixture was partitioned between water and methylene chloride. The organic extracts were washed with 1 N HCl, water, 1 N NaOH and brine, and concentrated. The residue was purified by column chromatography (Siθ2: 1:1 to 1:3 hexanes : EtOAc) , affording 2.33 g (71%) of the title compound. iNMR IS-MS, m/e 482 (M+l) Analysis for C27H35N3O5: Calcd: C, 67.3; H, 7.3; N, 8.7; Found: C, 67.4; H, 7.4; N, 8.7. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] - piperidine Using Deprotection Method D, 4- [ (4-methoxybenzoyl-D- phenylglycinyl) aminomethyl] -1-Boc-piperidine (2.38 g) afforded 1.56 g (82%) of 4- [ (4-methoxybenzoyl-D-phenyl- glycinyl) aminomethyl] iperidine . iNMR IS-MS, m/e 382 (M+l) General Procedure: Unless otherwise indicated, the product of Examples 201-210 was prepared from 4- [ (4-methoxybenzoyl- D-phenylglycinyl) aminomethyl] piperidine and the indicated aldehyde or ketone using Alkylation Method D. Example 201. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- isopropylpiperidine 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] piperidine (0.10 g, 0.26 mmol) and acetone afforded 89 mg (81%) of the title compound. iNMR IS-MS, m/e 424 (M+l) Analysis for C25H33N3O3: Calcd: C, 70.9; H, 7.9; N, 9.9; Found: C, 70.8; H, 7.8; N, 9.9. Example 202 . 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- (3 -pentyl) piperidine 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] piperidine (0.10 g, 0.26 mmol) and 3-pentanone afforded 57 mg (49%) of the title compound. X NMR IS-MS, m/e 452 (M+l) Example 203. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- (2 -indanyl) piperidine 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] piperidine (0.10 g, 0.26 mmol) and 2-indanone afforded 91 mg (78%) of the title compound. iNMR IS-MS, m/e 498 (M+l) Analysis for C25H33N3O3: Calcd: C, 74.8; H, 7.1; N, 8.4; Found: C, 74.5; H, 7.0; N, 7.9. Example 204. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- cyclopentylpiperidine 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] piperidine (0.10 g, 0.26 mmol) and cyclopentanone afforded 101 mg (86%) of the title compound. iNMR IS-MS, m/e 450 (M+l) Example 205 . 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- (cyclohexylmethyl) iperidine 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] piperidine (0.10 g, 0.26 mmol) and cyclohexanecarboxaldehyde afforded 98 mg (79%) of the title compound. iNMR IS-MS, m/e 478 (M+l) Example 206. 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- cyclohexylpiperidine 4- [ (4 -methoxybenzoyl -D-phenylglycinyl) aminomethyl] piperidine (0.10 g, 0.26 mmol) and cyclohexanone afforded 95 mg (79%) of the title compound. iNMR IS-MS, m/e 464 (M+l) Example 207. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- (tetrahydropyran-4-yl) iperidine 4- [ (4-methoxybenzoyl-D-phenylglycinyl) aminomethyl] piperidine (0.10 g, 0.26 mmol) and tetrahydro-4H-pyran-4-one afforded 78 mg (65%) of the title compound. iNMR IS-MS, m/e 466 (M+l) Example 208. 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- (tetrahydrothiopyran-4-yl) piperidine 4- [ (4 -Methoxybenzoyl -D-phenylglycinyl) aminomethyl] piperidine (0.10 g, 0.26 mmol) and tetrahydro-4H-thiopyran-4-one afforded 63 mg (50%) of the title compound. X NMR IS-MS, m/e 482 (M+l) Example 209. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1-methyl- piperidine 4- [ (4 -Methoxybenzoyl -D-phenylglycinyl) aminomethyl] piperidine (60 mg, 0.16 mmol) and paraformaldehyde afforded 59 mg (93%) of the title compound. iNMR IS-MS, m/e 396 (M+l) Example 210. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1-ethyl- piperidine 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] piperidine (60 mg, 0.16 mmol) and acetaldehyde afforded 23 mg (35%) of the title compound. iNMR IS-MS, m/e 410 (M+l) Examples 211-213 Preparation of Starting Materials 4- [ (Indole-6 -carbonyl-D-phenylglycinyl) aminomethyl] -1-Boc- piperidine Using Coupling Method C, 4- [ (D-phenylglycinyl) aminomethyl] - 1-Boc-piperidine (2.5 g, 6.8 mmol) and indole-6 -carboxylic acid (1.2 g, 7.6 mmol) afforded, after purification by column chromatography (Siθ2: 2:3 hexanes :EtOAc to EtOAc), 2.57 g (83%) of the title compound. iNMR IS-MS, m/e 491 (M+l) 4- [ (Indole-6-carbonyl-D-phenylglycinyl) aminomethyl] - piperidine Using Deprotection Method D, 4- [ (indole-6-carbonyl-D- phenylglycinyl) aminomethyl] -1-Boc piperidine (1.6 g, 3.3 mmol) afforded 4- [ (indole-6-carbonyl-D-phenylglycinyl ) - aminomethyl] piperidine (1.27 g, 79%). iNMR IS-MS, m/e 391 (M+l) General Procedure: Unless otherwise indicated, the product of Examples 211-213 was prepared from 4- [ (indole-6-carbonyl ■ D-phenylglycinyl) aminomethyl] piperidine and the indicated aldehyde or ketone using Alkylation Method D. Example 211. 4- [ (Indole-6-carbonyl-D-phenylglycinyl) aminomethyl] -1- isopropylpiperidine 4- [ (Indole-6-carbonyl-D-phenylglycinyl) aminomethyl] - piperidine (0.10 g, 0.26 mmol) and acetone afforded 16 mg (14%) of the title compound. iNMR IS-MS, m/e 433 (M+l) Example 212. 4- [ (Indole-6-carbonyl-D-phenylglycinyl) aminomethyl] -1- cyclopentylpiperidine 4- [ (Indole-6-carbonyl-D-phenylglycinyl) aminomethyl] - piperidine (0.10 g, 0.26 mmol) and cyclohexanone afforded 19 mg (16%) of the title compound. iNMR IS-MS, m/e 459 (M+l) Example 213. 4- [ (Indole-6-carbonyl-D-phenylglycinyl) aminomethyl] -1- cyclohexylmethylpiperidine 4- [ (Indole-6-carbonyl-D-phenylglycinyl) aminomethyl] - piperidine (0.10 g, 0.26 mmol) and cyclohexanecarboxaldehyde afforded 14 mg (11%) of the title compound. iN R IS-MS, m/e 487 (M+l) Examples 214-217 Preparation of Starting Materials 4- [ (Benzyloxycarbonyl-D-phenylglycinyl) ] -1-Boc-piperidine Using Coupling Method C, D-phenylglycine (6.10 g, 21.4 mmol) and 4-amino-l-Boc-piperidine (4.27 g, 21.4 mmol) afforded, after purification by column chromatography (Siθ2: 7:3 hexanes : EtOAc) , 8.44 g (84%) of the title compound. iNMR IS-MS, m/e 468 (M+l) . Analysis for C26 H 33 N 3θ5= Calcd: C, 66.3; H, 7.1; N, 9.0; Found: C, 66.5; H, 7.1; N, 9.0. 4- [ (D-Phenylglycinyl) amino] -1-Boc-piperidine Using Deprotection Method C, 4- [ (benzyloxycarbonyl-D- phenylglycinyl) amino] -1-Boc-piperidine (8.0 g, 17 mmol) afforded 6.1 g (90%) of the title compound, which was used without further purification. iNMR IS-MS, m/e 334 (M+l) . 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) amino] -1-Boc- piperidine Using Acylation Method C, 4- [ (D-phenylglycinyl) amino] -1-Boc piperidine (2.23 g, 6.7 mmol) afforded, after purification by column chromatography (Siθ2: 1:1 hexanes EtOAc), 2.44 g (78%) of the title compound. iNMR IS-MS, m/e 468 (M+l) . 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) amino] piperidine Using Deprotection Method D, 4- [ (4-methoxybenzoyl-D- phenylglycinyl) amino] -1-Boc-piperidine (2.32 g) afforded 1.53 g (84%) of 4- [ (4-methoxybenzoyl-D-phenylglycinyl) - amino] piperidine . iNMR IS-MS, m/e 368 (M+l) . General Procedure: Unless otherwise indicated, the product of Examples 214-217 was prepared from 4- [ (4-methoxybenzoyl- D-phenylglycinyl) amino] piperidine and the indicated aldehyde or ketone using Alkylation Method D. Example 214. 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) aminomethyl] -1- (3 -pentyl) piperidine 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) amino] piperidine (0.11 g, 0.3 mmol) and 3-pentanone afforded 81 mg (62%) of the title compound. iNMR IS-MS, m/e 438 (M+l) . Example 215. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) amino] -1- (2-indanyl) - piperidine 4- [ (4 -Methoxybenzoyl -D-phenylglycinyl) amino] piperidine (0.11 g, 0.3 mmol) and 2-indanone afforded 121 mg (83%) of the title compound. iNMR IS-MS, m/e 484 (M+l) . Example 216. 4- [ (4-Methoxybenzoyl-D-phenylglycinyl) amino] -1-cyclopentyl- piperidine 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) amino] piperidine (0.11 g, 0.3 mmol) and cyclopentanone afforded 103 mg (79%) of the title compound. iNMR IS-MS, m/e 436 (M+l) . Example 217. 4- [ (4 -Methoxybenzoyl-D-phenylglycinyl) amino] -1-cyclohexyl- piperidine 4- [ ( -Methoxybenzoyl -D-phenylglycinyl) amino] piperidine (0.11 g, 0.3 mmol) and 2 -cyclohexanone afforded 112 mg (83%) of the title compound. iNMR IS-MS, m/e 450 (M+l) . Examples 218-220 Preparation of Starting Materials 4- [ (Indole-6-carbonyl-D-phenylglycinyl) mino] -1-Boc- piperidine Using Acylation Method C, 4- [ (D-phenylglycinyl) amino] -1- Boc-piperidine (2.24 g, 6.15 mmol) and indole-6- carboxylic acid afforded 4- [ (indole-6-carbonyl-D-phenyl- glycinyl) amino] -1-Boc-piperidine (2.66 g, 82%). iNMR IS-MS, m/e 477 (M+l) . 4- [ (Indole-6-carbonyl-D-phenylglycinyl) amino] piperidine Using Deprotection Method C, 4- [ (indole-6-carbonyl-D- phenylglycinyl) amino] -1-Boc-piperidine (1.2 g, 2.5 mmol) afforded 4- [ (indole-6-carbonyl-D-phenylglycinyl) amino] - piperidine (0.81 g, 83%). X NMR IS-MS, m/e 377 (M+l) . General Procedure: Unless otherwise indicated, the product of Examples 218-220 was prepared from 4- [ (indole-6-carbonyl- D-phenylglycinyl) amino] piperidine and the indicated aldehyde or ketone using Alkylation Method D. Example 218. 4- [ (Indole- 6-carbonyl-D-phenylglycinyl) amino] -1-isopropyl- piperidine 4- [ (Indole-6-carbonyl-D-phenylglycinyl) amino] piperidine (0.10 g, 0.27 mmol) and acetone afforded 21 mg (19%) of the title compound. iN R IS-MS, m/e 419 (M+l) . Example 219. 4- [ (Indole- 6 -carbonyl-D-phenylglycinyl) amino] -1-cyclo- pentylpiperidine 4- [ (Indole-6 -carbonyl-D-phenylglycinyl) amino] piperidine (0.10 g, 0.27 mmol) and cyclopentanone afforded 28 mg (24%) of the title compound. iNMR IS-MS, m/e 445 (M+l) . Example 220. 4- [ (Indole-6-carbonyl-D-phenylglycinyl) amino] -1- (cyclo- hexylmethyl) piperidine 4- [ (Indole-6-carbonyl-D-phenylglycinyl) amino] piperidine (0.10 g, 0.27 mmol) and cyclohexanecarboxaldehyde afforded 17 mg (14%) of the title compound. iNMR IS-MS, m/e 473 (M+l) . Examples 221-246 Preparation of Starting Materials l-Methyl-4, 4' -bispiperidine hydrobromide dihydrobromide A solution of 4, 4 ' -bipyridine (34.2 g, 100 mmol) in acetone was treated with methyl p-toluenesulfonate. After 3 days, the salt (28 g, 80%) was isolated by filtration. The salt (44.0 g) was then treated with 10% Pd/C in acetic acid (400 mL) and hydrogen gas (4.1 bar) at 60 °C. After 16 h, the mixture was concentrated, the residue was dissolved in acetone, and then treated with hydrogen bromide in acetic acid. The resulting salt (36 g, 86%) was isolated by filtration as a dihydrobromide. iNMR 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine Using Coupling Method A, benzyloxycarbonyl-D-phenylglycine (16 g, 56 mmol) and l-methyl-4 , 4 ' -bispiperidine dihydrobromide (17.2 g, 50 mmol) afforded, after treatment of the crude acylation product with HBr (150 mL) and acetic acid (150 mL) at 60 °C for 6 h, 8.4 g (54%) of the title compound . iNMR IS-MS, m/e 316 (M+l) Analysis for C1 H29N3O: Calcd: C, 72.3; H, 9.3; N, 13.3; Found: C, 71.9; H, 9.2; N, 13.1. General Procedure: Unless otherwise indicated, the product of Examples 221-246 (or a protected derivative thereof) was prepared from 1- (D-phenylglycinyl) -1' -methyl-4 , 4 ' - bispiperidine and the indicated acid using procedures similar to Acylation Method C. Removal of Protecting Group: Where a protecting group was present in the acylation procedure, the procedure for its removal is described. Example 221. 1- (4-Methoxy-3-methylbenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (200 mg, 0.64 mmol) and 4-methoxy-3-methylbenzoic acid (116 mg, 0.70 mmol) afforded 159 mg (54%) of the title compound. iNMR IS-MS, m/e 464 (M+l) Analysis for C25H33N3O3 • 0.35 H 2 0: Calcd: C, 71.6; H, 8.1; N, 8.9; Found: C, 71.5; H, 7.8; N, 9.0. Example 222. 1- [5-Methylthiothiophene-2-carbonyl-D-phenylglycinyl] -1' - methyl-4, 4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (200 mg, 0.64 mmol) and 5 -methylthiothiophene-2 -carboxylic acid (120 mg, 0.70 mmol) afforded 190 mg (63%) of the title compound. X NMR IS-MS, m/e 472 (M+l) Example 223. 1- (3-Chloro-4-methoxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4 , 4' -bispiperidine (200 mg, 0.64 mmol) and 3-chloro-4-methoxybenzoic acid (130 mg, 0.70 mmol) afforded 182 mg (59%) of the title compound. iNMR IS-MS, m/e 484 (M+l) Example 224. 1- (5-Methoxybenzofuran-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4 ' -bispiperidine (200 mg, 0.64 mmol) and 5-methoxybenzofuran-2-carboxylic acid (135 mg, 0.70 mmol) afforded 298 mg (96%) of the title compound. iNMR IS-MS, m/e 490 (M+l) Analysis for C29H35N3O4: Calcd: C, 71.1; H, 7.2; N, 8.6; Found: C, 71.5; H, 7.4; N, 8.8. Example 225. 1- (5-Acetylthiophene-2-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (200 mg, 0.64 mmol) and 5-acetylthiophene-2 -carboxylic acid (119 mg, 0.70 mmol) afforded 245 mg (83%) of the title compound. iNMR IS-MS, m/e 468 (M+l) Analysis for C26 H 33 N 3°3 S: Calcd: C, 66.8; H, 7.1; N, 9.0; Found: C, 66.5; H, 7.1; N, 9.0. Example 226. 1- (4-Chloro-3-methylbenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4 , 4 ' -bispiperidine (315 mg, 1.00 mmol) and 4-chloro-3-methylbenzoic acid (171 mg, 1.00 mmol) afforded 240 mg (51%) of the title compound. iNMR IS-MS, m/e 468 (M+l) Analysis for C26 H 33 N 3°3 S: Calcd: C, 69.3; H, 7.3; N, 9.0; Found: C, 68.9; H, 7.2; N, 8.9. Example 227. 1- (5-Methylindole-2-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (315 mg, 1.00 mmol) and 5-methylindole-2-carboxylic acid (263 mg, 1.50 mmol) afforded 240 mg (51%) of the title compound. iNMR IS-MS, m/e 473 (M+l) . Example 228. 1- (5-Methoxyindole-2-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (315 mg, 1.00 mmol) and 5 -methoxyindole-2 -carboxylic acid (1.50 mmol) afforded 77 mg (16%) of the title compound. iNMR IS-MS, m/e 489 (M+l) Analysis for C26 H 33 N 3°3 S: Calcd: C, 69.3; H, 7.3; N, 9.0; Found: C, 68.9; H, 7.2; N, 8.9. Example 229. 1- (Benzothiazole-2-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (315 mg, 1.00 mmol) and benzothiazole-2 -carboxylic acid (200 mg, 1.12 mmol) afforded 180 mg (16%) of the title compound. 1-N.MR IS-MS, m/e 477 (M-l) Example 230 . 1- (5-Fluoroindole-2 -carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (315 mg, 1.00 mmol) and 5-fluoroindole-2 -carboxylic acid (280 mg, 1.50 mmol) afforded 80 mg (17%) of the title compound. iNMR IS-MS, m/e 477 (M+l) Analysis for C 8 H 33 FN 4θ2 Η2O: Calcd: C, 68.0; H, 7.1; N, 11.3; Found: C, 68.0; H, 6.7; N, 11.1. Example 231. 1- (Napthalene-2-carbonyl-D-phenylglycinyl) -1' -methyl-4,4' - bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4 , 4 ' -bispiperidine (315 mg, 1.00 mmol) and napthalene-2-carboxylic acid (220 mg, 1.28 mmol) afforded 160 mg (38%) of the title compound. iNMR IS-MS, m/e 470 (M+l) Analysis for C30H35N3O2 • 0.5 H 0: Calcd: C, 75.3; H, 7.6; N, 8.8; Found: C, 75.6; H, 7.4; N, 8.9. Example 232. 1- (6-Methoxyindole-2-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4 ' -bispiperidine Using Coupling Method C, 1- (D-phenylglycinyl) -1' -methyl- 4,4 ' -bispiperidine (315 mg, 1.00 mmol) and 6-methoxyindole- 2-carboxylic acid (191 mg, 1.00 mmol) afforded 200 mg (41%) of the title compound. iNMR IS -MS , m/e 489 (M+ l ) Analysis for C29H36N4O3 • 0.5 H 0: Calcd: C, 70.0; H, 7.5; N, 11.3; Found: C, 69.3; H, 7.5; N, 11.1. Example 233. 1- (5-Chloroindole-2-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine Using Coupling Method A, 1- (D-phenylglycinyl) -1' -methyl - 4,4' -bispiperidine (315 mg, 1.00 mmol) and 5-chloroindole-2- carboxylic acid (230 mg, 1.15 mmol) afforded 220 mg (45%) of the title compound. iNMR IS-MS, m/e 493 (M+l) Analysis for C28H33CIN4O2 • 0.75 H 2 0: Calcd: C, 66.4; H, 6.9; N, 11.1; Found: C, 66.8; H, 6.6; N, 10.9. Example 234. 1- (3-Hydroxybenzoyl-D-phenylglycinyl) -1' -methyl-4,4' - bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (200 mg, 0.635 mmol) and 3-benzyloxybenzoic acid (158 mg, 0.698 mmol) afforded 100 mg (30%) of 1- (3 -benzyloxybenzoyl -D-phenyl - glycinyl) -1' -methyl-4, 4' -bispiperidine . A solution of this material and 10% Pd/C in 3 mL of EtOH was treated with hydrogen gas (1 atm) . After 16 h, the mixture was filtered, concentrated, and the residue triturated with EtOAc, affording 27 mg (32%) of the title compound. X NMR IS-MS, m/e 436 (M+l) . Example 235 . 1- (3 -Hydroxy-4-methylbenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (200 mg, 0.635 mmol) and 3 -acetoxy-4 -methylbenzoic acid (135 mg, 0.698 mmol) afforded, after treatment of the crude acylation mixture with methanolic potassium carbonate and purification by column chromatography (4% to 6% 2 N NH3 in methanol : - methylene chloride) , 132 mg (46%) of the title compound. X NMR IS-MS, m/e 450 (M+l) . Analysis for C27H35N3O3 • 0.5 H 2 0: Calcd: C, 71.4; H, 7.9; N, 9.3; Found: C, 71.4; H, 7.9; N, 9.2. The protected starting acid for the above procedure was prepared as follows: 3 -Acetoxy-4 -methylbenzoic acid A solution of 3 -hydroxy-4 -methylbenzoic acid (3.0 g, 19.7 mmol) in acetic anhydride (5.6 mL) was treated with sulfuric acid (0.03 mL) , heated to 70 °C, cooled and diluted with water. The resulting solid was collected by filtration yielding 1.14 g (30%) of the title compound, which was used without further purification. iNMR Example 236. 1- (2-Hydroxybenzoyl-D-phenylglycinyl) -1' -methyl-4,4' - bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (200 mg, 0.635 mmol) and 2-acetoxybenzoic acid (125 mg, 0.698 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the crude acylation mixture with methanolic potassium carbonate and purification by column chromatography, 100 mg (36%) of the title compound. iNMR IS-MS, m/e 436 (M+l) . Example 237. 1- (4-Chloro-3-hydroxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (200 mg, 0.635 mmol) and 4-chloro-3-acetoxybenzoic acid (150 mg, 0.698 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the crude acylation mixture with methanolic potassium carbonate and purification by column chromatography, 110 mg (37%) of the title compound. iNMR IS-MS, m/e 470 (M+l) . Example 238. 1- (4-Chloro-2-hydroxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (200 mg, 0.635 mmol) and 4-chloro-2-acetoxybenzoic acid (150 mg, 0.698 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the crude acylation mixture with methanolic potassium carbonate and purification by radial chromatography, 60 mg (20%) of the title compound. iNMR IS-MS, m/e 470 (M+l) . Example 239. 1- (4-Chloro-3-methoxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (200 mg, 0.635 mmol) and 4 -chloro-2 -methoxybenzoic acid (130 mg, 0.698 mmol) afforded, after purification by column chromatography, 120 mg (39%) of the title compound. iN R IS-MS, m/e 484 (M+l) Analysis for C27H34CIN3O3 : Calcd: C, 67.0; H, 7.1; N, 8.7; Found: C, 66.8; H, 7.1; N, 8.8. Example 240. 1- (3-Hydroxy-4-methoxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (200 mg, 0.635 mmol) and 3 -acetoxy- -methoxybenzoic acid (146 mg, 0.698 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the crude acylation mixture with methanolic potassium carbonate and purification by column chromatography, 52 mg (18%) of the title compound. iNMR IS-MS, m/e 466 (M+l) . Example 241. 1- (2, 4 -Dihydroxybenzoyl-D-phenylglycinyl) -1' -methyl-4,4' - bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (200 mg, 0.635 mmol) and 2 , 4-diacetoxybenzoic acid (167 mg, 0.698 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the crude acylation mixture with methanolic potassium carbonate and purification by column chromatography, 145 mg (50%) of the title compound. iNMR IS-MS, m/e 452 (M+l) . Analysis for C26H33N3O4 • 0.75 H 0: Calcd: C, 67.2; H, 7.5; N, 9.0; Found: C, 67.3; H, 7.2; N, 9.3. Example 242. 1- (2-Hydroxy-4-methoxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4,4' -bispiperidine (200 mg, 0.635 mmol) and 2 -acetoxy-4 -methoxybenzoic acid (146 mg, 0.698 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the crude acylation mixture with methanolic potassium carbonate and purification by ion exchange chromatography (Varian, SCX) , 118 mg (40%) of the title compound. iNMR IS-MS, m/e 466 (M+l) . Analysis for C27H35N3O4 • 0.50 H 2 0: Calcd: C, 68.3; H, 7.7; N, 8.9; Found: C, 68.2; H, 7.4; N, 9.1. Example 243 . 1- (5-Chloro-2 -hydroxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4 ' -bispiperidine (200 mg, 0.635 mmol) and 2-acetoxy-5-chlorobenzoic acid (150 mg, 0.698 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the crude acylation mixture with methanolic potassium carbonate and purification by ion exchange chromatography (Varian, SCX) , 100 mg (33%) of the title compound. X NMR IS-MS, m/e 471 (M+l) . Analysis for C26 H 32 lN 3°3 " ° • 25 H 2 0: Calcd: C, 65.8; H, 6.9; N, 8.9; Found: C, 65.9; H, 7.0; N, 9.2. Example 244. 1- (3-Chloro-4-hydroxybenzoyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (315 mg, 1.00 mmol) and 4-acetoxy-3-chlorobenzoic acid (321 mg, 1.50 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the acylation mixture with methanolic potassium carbonate, 50 mg (27%) of the title compound. iNMR IS-MS, m/e 470 (M+l) . Analysis for C26 H 32 clN 3°3 * 1 • 0 H 2 0: Calcd: C, 64.0; H, 7.0; N, 8.6; Found: C, 63.7; H, 7.0; N, 8.7. Example 245 . 1- (3-Hydroxynaphthalene-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4 , 4 ' -bispiperidine (315 mg, 1.00 mmol) and 3 -acetoxynaphthalene-2 -carboxylic acid (300 mg, 1.30 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the acylation product with methanolic potassium carbonate, 128 mg (38%) of the title compound. iNMR IS-MS, m/e 486 (M+l) . Example 246. 1- (6-Hydroxynaphthalene-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine 1- (D-Phenylglycinyl) -1' -methyl-4 , 4' -bispiperidine (315 mg, 1.00 mmol) and 6-acetoxynaphthalene-2-carboxylic acid (300 mg, 1.30 mmol; prepared using methods substantially equivalent to those described for 3 -acetoxy-4 -methylbenzoic acid) afforded, after treatment of the acylation product with methanolic potassium carbonate, 210 mg (43%) of the title compound. X NMR IS-MS, m/e 486 (M+l) . Analysis for C30H35N3O3 • 1.0 H 2 0: Calcd: C, 71.6; H, 7.4; N, 8.3; Found: C, 71.5; H, 7.3; N, 8.3. Examples 247-251. Preparation of Starting Materials 1- (Benzyloxycarbonyl-D-phenylglycinyl) piperidine-4-methanol Using Coupling Method C, benzyloxycarbonyl -D-phenylglycine (8.41 g, 29.5 mmol) and 4-piperidinemethanol (3.85 g, 37.4 mmol) afforded 10.2 g (93%) of the title compound. iNMR 1- (D-Phenylglycinyl) piperidine-4-methanol Using Deprotection Method C, 1- (benzyloxycarbonyl-D- phenylglycinyl) piperidine-4 -methanol (3.93 g, 29.5 mmol) and 10% palladium on carbon (1.30 g) afforded 2.31 g (88%) of the title compound. iNMR IS-MS, m/e 249 (M+l) . 1- (4-Methoxybenzoyl-D-phenylglycinyl) piperidine-4 -methanol Using methods substantially equivalent Acylation Method C described prior to Example 201, 1- (D-phenylglycinyl) - piperidine-4 -methanol (1.23 g, 4.96 mmol) and p-anisoyl chloride (0.888 g, 5.21 mmol) afforded, after purification by column chromatography (Siθ2: 1:1 to 1:9 hexanes : EtOAc) , 1.26 g (66%) of the title compound. iNMR IS-MS, m/e 383 (M+l) . 1- (4-Methoxybenzoyl-D-phenylglycinyl) iperidine-4 - carboxaldehyde A solution of 1- (4 -methoxybenzoyl -D-phenylglycinyl ) - piperidine-4 -methanol (0.800 g, 2.08 mmol) and N-methyl- morpholine oxide (0.366 g, 3.13 mmol) in methylene chloride (15 mL) was treated with tetrapropylammonium perruthenate (TPAP, 2 mg) . After 14 h, the mixture was treated with additional TPAP (5 mg) . After 20 h, the mixture was treated with additional TPAP (5 mg) . After 32 h, the mixture was loaded directly onto a column and purified by column chromatography (Siθ2: 1:1 to 1:4 hexanes : EtOAc) affording 0.286 g (36%) of the title compound. iNMR IS-MS, m/e 381 (M+l) . General Procedure: Unless otherwise indicated, the product of Examples 247-251 was obtained from the indicated amine and 1- (4 -methoxybenzoyl -D-phenylglycinyl) piperidine- - carboxaldehyde using Alkylation Method D. Example 247. 1- [ (4-Methoxybenzoyl-D-phenylglycinyl) ] -4- [ (isopropylamino) - methyl] piperidine hydrochloride 1- (4 -Methoxybenzoyl -D-phenylglycinyl) iperidine- - carboxaldehyde (0.050 g, 0.131 mmol) and isopropylamine afforded, after treatment of the isolated product with excess hydrochloric acid in methanol and concentration, 37 mg of the title compound as a hydrochloride salt. X NMR IS-MS, m/e 424 (M+l) Example 248. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- [ (dimethylamino) - methyl] piperidine 1- (4 -Methoxybenzoyl -D-phenylglycinyl ) piperidine-4 - carboxaldehyde (0.050 g, 0.131 mmol) and dimethylamine afforded 25 mg (47%) of the title compound. iNMR IS-MS, m/e 410 (M+l) Example 249 . 1- [ (4-Methoxybenzoyl-D-phenylglycinyl) ] -4- [ (N,N-diethyl- amino) methyl] iperidine hydrochloride 1- (4-Methoxybenzoyl-D-phenylglycinyl)piperidine-4- carboxaldehyde (0.050 g, 0.131 mmol) and diethylamine afforded, after treatment of isolated product with excess hydrochloric acid in methanol and concentration, 42 mg of the title compound as a hydrochloride salt. iNMR IS-MS, m/e 438 (M+l) Example 250. 1- [ (4-Methoxybenzoyl-D-phenylglycinyl) ] -4- [ (1-pyrrolidinyl) methyl] piperidine 1 - (4 -Methoxybenzoyl-D-phenylglycinyl ) iperidine-4 - carboxaldehyde (0.050 g, 0.131 mmol) and pyrrolidine afforded 27 mg (47%) of the title compound. iNMR IS-MS, m/e 436 (M+l) Example 251. 1- [ (4-Methoxybenzoyl-D-phenylglycinyl) ] -4- [ (3-pyrrolin- 1-yl) methyl] iperidine hydrochloride 1- (4-Methoxybenzoyl-D-phenylglycinyl) piperidine-4- carboxaldehyde (0.050 g, 0.131 mmol) and 3-pyrroline afforded, after treatment of isolated product with excess hydrochloric acid in methanol and concentration, 43 mg of the title compound as a hydrochloride salt. iNMR IS-MS, m/e 434 (M+l) Examples 252 to 253 Preparation of Starting Materials 4- [ (Benzyloxycarbonyl-D-phenylglycinyl) aminomethyl] - piperidine Using Deptrotection Method D, 4- [ (benzyloxycarbonyl -D- phenylglycinyl) aminomethyl] -1-Boc piperidine (2.70 g, 5.61 mmol) afforded 1.56 g (73%) of the title compound. iNMR IS-MS, m/e 382 (M+l) 4- [ (Benzyloxycarbonyl-D-phenylglycinyl) aminomethyl] -1- cyclopentylpiperidine Using Alkylation Method D, 4- [ (benzyloxycarbonyl-D- phenylglycinyl) aminomethyl] piperidine (1.50 g, 3.93 mmol) and cyclopentanone afforded 3.48 g (91%) of the title compound . X NMR IS-MS, m/e 450 (M+l) 4- [ (D-Phenylglycinyl) aminomethyl] -1-cyclopentylpiperidine Using a deprotection procedure similar to that described above for preparation of 1- (D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine, 4- [ (benzyloxycarbonyl-D-phenylglycinyl) aminomethyl] -1-cyclopentylpiperidine (1.70 g, 3.78 mmol) afforded 0.75 g (63%) of the title compound. iNMR IS-MS, m/e 316 (M+l) General Procedure: Using Coupling Method A, 4- [ (D-phenylglycinyl) aminomethyl] -1-cyclopentylpiperidine was coupled with the indicated acid. Example 252 . 4- [ (5-Chloroindole-2-carbonyl-D-phenylglycinyl) aminomethyl] 1-cyclopentylpiperidine 4- [ (D-Phenylglycinyl) aminomethyl] -1-cyclopentylpiperidine (0.100 g, 0.317 mmol) and 5-chloroindole-2 -carboxylic acid (0.075 g, 0.38 mmol) afforded 156 mg (98%) of the title compound. iNMR IS-MS, m/e 493 (M+l) Example 253. 4- [ (3-Methylindole-6-carbonyl-D-phenylglycinyl) aminomethyl] 1-cyclopentylpiperidine 4- [ (D-Phenylglycinyl) aminomethyl] -1-cyclopentylpiperidine (0.100 g, 0.317 mmol) and 3-methylindole-6-carboxylic acid (0.067 g, 0.38 mmol) afforded 137 mg (91%) of the title compound. X NMR IS-MS, m/e 473 (M+l) Particular Analytical Methods for Examples 254-276: HPLC Analysis (Method A) : Dynamax (trademark) C18, 60A column. The elution system consisted of a linear gradient from 90:10(95% H 2 0, CH 3 CN)/(95% CH 3 CN, H 2 0) to (95% CH 3 CN, H 2 0) over 20 min, followed by (95% CH 3 CN,H2θ) isocratic elution over 15 min. The flow rate was 1 mL/min. UV Detection was performed at 254 nm unless otherwise noted. HPLC Analysis (Method B) : Microsorb-MV (trademark) C8 (4.6 x 250 mm) column. The elution system consisted of a linear gradient from 95:5 (2.5% TFA in H 2 0):(2.5% TFA in acetonitrile) to 0:100 (2.5% TFA in H 2 0):(2.5% TFA in acetonitrile) over 25 min at 30 °C and a flow rate of 1 mL/min. UV Detection was performed at 254 nm unless otherwise noted. HPLC Analysis (Method C) : Dynamax (trademark), C18, 60A column. The elution system consisted of a linear gradient from 95:5 (0.2% TFA in H 2 0) / (0.2% TFA in CH 3 CN) to 5:95 (0.2% TFA in H 0) / (0.2% TFA in CH 3 CN) over 20 min, followed by (0.2% TFA in CH 3 CN) isocratic elution over 15 min. The flow rate was 1 mL/min. UV Detection was performed at 254 nm unless otherwise noted. HPLC Analysis (Method D) : Waters Symmetry (trademark) , C18 (4.6 x 250 mm) column. The elution system consisted of a linear gradient from 95:5 (0.2% TFA in H 2 O)/(0.2% TFA in CH 3 CN) to 5:95 (0.2% TFA in H 2 O)/(0.2% TFA in CH 3 CN) over 20 min, followed by (0.2% TFA in CH 3 CN) isocratic over 15 min. The flow rate was 1 mL/min. UV Detection was performed at 254 nm unless otherwise noted. HPLC Analysis (Method E) : Microsorb-MV C18 (4.6 x 250 mm) column. The elution system consisted of a linear gradient from 90:10 (2.5% TFA in H 2 0):(2.5% TFA in acetonitrile) to 10:90 (2.5% TFA in H 2 0):(2.5% TFA in acetonitrile) over 25 min at 30 °C and a flow rate of 1 mL/min. UV Detection was performed at 254 nm unless otherwise noted. API-MS (atmospheric pressure chemical ionization mass spectra) were obtained on a PESciex (trademark) API 150EX with a heated nebulizer and nitrogen as the reagent gas in positive ion mode. Examples 254 to 257 Preparation of Starting Materials (R) - (-) -Boc-phenylglycinol: Di- ert-butyl dicarbonate (232.4 g, 1.06 mol) was added to a well stirred, ice bath cooled mixture of (R) - (-) -2-phenylglycinol (121.7 g, 0.887 mol), potassium carbonate (171.7 g, 1.24 mol), 1,4-dioxane (1 L) , and water(l L) . The temperature rose from 5 °C - 11 °C during the addition. The reaction was allowed to stir overnight. The reaction was diluted with water (1 L) , and cooled in ice-water. The resultant precipitate was collected by vacuum filtration, washed with water, air dried, and vacuum dried at 40 °C overnight to afford 201.7 g (95%) as a white solid. IH-NMR (CDCI3) TLC Rf = 0.45 (83% CH 2 C1 2 , EtOAc) (R) - (-) - [2- [ (Methylsulphonyl) oxy] -1-phenylethyl] carbamic acid 1, 1-dimethylethyl ester The sulphonate was prepared from the above alcohol according to J " . Med. Chem . 1994, 37, 1819. IH-NMR (CDCI3) TLC R f = 0.45 (95% CH 2 C1 2 , EtOAc) (R) -2- [ (Butoxycarbonyl) amino] -2-phenylethyl azide The azide was prepared form the above sulphonate according to J " . Med . Chem . 1994, 37, 1819. IH-NMR (CDCI3) TLC Rf = 0.85 (95% CH 2 C1 2 , EtOAc) (R) -2- (4-Methoxybenzoylamino) -2 -phenylethyl azide (R) -2- [ (Butoxycarbonyl) amino] -2 -phenylethyl azide (47.8 g, 0.182 mole) was added to trifluoroacetic acid (500 mL) with stirring and ice-water bath cooling. The cooling bath was removed, the reaction was allowed to stir 1 h, and the solvent was removed in vacuo at 35 °C water bath temperature. The residue was co-evaporated with toluene to give a weight of 75.0 g. The residue was dissolved in 1,4-dioxane (500 mL) and water (500 mL) , with ice-water bath cooling, and then potassium carbonate (113.5 g, 0.82 mol), and anisoyl chloride (37.3 g, 0.219 mol) were added. Another portion of 1,4-dioxane (300 mL) was added to facilitate stirring. After stirring over the weekend, water (1 L) was added. The mixture was cooled to -15 °C, and vacuum filtered to collect a white solid. The solid was washed with water, air dried, and then dried under vacuum at 50 °C for 4 h to afford 46.3 g (86%) . IH-NMR (CDC1 3 ) TLC Rf = 0.85 (83% CH 2 Cl 2 , EtOAc) (R) -2- (4-Methoxybenzoylamino) -2-phenylethylamine (R) -2- (4-methoxybenzoylamino) -2 -phenylethyl azide (46.3 g) was combined with 10% palladium on carbon in THF (400 mL) , methanol (100 mL) and was stirred under a hydrogen atmosphere. Analysis by TLC (70% methylene chloride, ethyl acetate) indicated absence of starting material after stirring overnight. The solution was filtered through diatomaceous earth, rinsed with THF, and evaporated. The resulting solid was recrystallized with ethyl acetate, and dried under vacuum at 60 °C for 1 h to afford 35.4 g (84%) of a white crystalline solid. IH-NMR ( CDCI3 ) TLC Rf = 0.17 (90% CH 2 C1 2 , 9% Methanol, 1% NH4OH) Examples 254-257 were prepared from (R) -2- (4 -methoxybenzoyl- amino) -2-phenylethylamine and the indicated acid chloride using the acylation method described in Example 254 (Acylation Method A) . Example 254. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -4 -methyl- benzamide (Acylation Method A) p-Toluoyl chloride (0.22 mL, 1.6 mmol) was added via syringe to a 15 °C stirring mixture of (R) -2- (4 -methoxybenzoylamino) -2-phenylethylamine (0.40 g, 1.48 mmol), potassium carbonate (0.27 g, 1.9 mmol), 1,4-dioxane (8 mL) , and water (4 mL) . TLC analysis (80% methylene chloride, 18% methanol, 2% ammonium hydroxide) indicated reaction completion within 1 h. The solution was diluted with water, and the precipitated solid was collected by vacuum filtration. The precipitate was recrystallized from methanol and dried under vacuum at 50 °C overnight to afford the title compound (0.42 g, 72%) as a white solid. IH-NMR (DMSO) IS-MS, m/e = 389 (M+l) Analysis for C24H24N2O3 : Calcd: C, 74.21; H, 6.23; N, 7.21; Found: C, 73.82; H, 6.32; N, 7.04. HPLC Analysis (Method A): 99.3%, RT : 21.35 min. Melting Point: 230-238 °C Example 255 . (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -4-ethyl- benzamide Prepared from 4-ethylbenzoyl chloride (84%) . IH-NMR (DMSO) IS-MS, m/e = 403 (M+l) Analysis for C25H26 2O3: Calcd: C, 74.60; H, 6.51; N, 6.96; Found: C, 74.25; H, 6.63; N, 6.83. HPLC Analysis (Method A) : 95.4%, RT=22.62 min. Melting Point: 222-229 °C Example 256. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -4-isopropyl- benzamide Prepared from 4-isopropylbenzoyl chloride (40%) . IH-NMR (DMSO) IS-MS, m/e = 417 (M+l) Analysis for C26H28N2O3: Calcd: C, 74.97; H, 6.78; N, 6.73; Found: C, 74.61; H, 6.78; N, 6.61. HPLC Analysis (Method A): 98.4%, RT=23.77 min. Melting Point: 239-244 °C Example 257. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -4-tert- butylbenzamide Prepared from 4- ert-butylbenzoyl chloride (89%). IH-NMR (DMSO) IS-MS, m/e = 431 (M+l) Analysis for C27H30N2O3 • 0.25H 2 0: Calcd: C, 74.54; H, 7.07; N, 6.44; Found: C, 74.39; H, 7.13; N, 6.34. HPLC Analysis (Method A) : 96.4%, RT=25.04 min. Melting Point = 171-175 °C Examples 258 to 266 Preparation of Starting Materials (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -1-tert- butoxycarbonylpiperidine-4 -carboxamide . N-Boc-iso-nipecotic acid (2.13 g, 9.5 mmol) followed by (R) -2- (4-methoxybenzoylamino) -2-phenylethylamine (2.34 g, 8.7 mmol) were added at 2 °C to a stirring mixture of EDCI (2.5 g, 13.0 mmol), and HOBt (1.64 g, 12.1 mmol) in DMF (50 mL) . Triethylamine (1.8 mL, 13.0 mmol) was added dropwise. The reaction was allowed to warm to room temperature, with stirring overnight. Water (100 mL) was added, and the aqueous mixture was extracted with ethyl acetate (2 X 200 mL) . The extracts were combined, and THF (200 mL) was added. Next, the organic layers were washed with water (5 X 70 mL) , aqueous NaHC0 3 (70 mL) f and brine (100 mL) . The organic layer was dried over Na2Sθ4, filtered, and evaporated. The crude residue (4.2 g, 100%), was recrystallized from ethyl acetate and hexanes to afford 2.9 g (71%) of a white solid. IH-NMR (DMSO) IS-MS, m/e = 482 (M+l) Analysis for C27H30N2O3: Calcd: C, 67.34; H, 7.33; N, 8.73; Found: C, 67.34; H, 7.46; N, 8.66. HPLC Analysis (Method A) : 98.8%, RT=20.72 min. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] piperidine-4- carboxamide trifluoroacetate (Deprotection Method A) Trifluoroacetic acid was added to a stirring suspension of (R) -N- [2- (4-methoxybenzoylamino) -2- phenylethyl] -l-tert-butoxycarbonylpiperidine-4-carboxamide (2.0 g, 4.2 mmol), methylene chloride (20 mL) , and anisole (0.5 g, 4.6 mmol) at room temperature. A solution was obtained and bubbling was observed. After 1 h, the reaction mixture was evaporated at 40 °C. The residue was taken up in warm methanol, and to this stirring solution was added ether to precipitate the product. The precipitate was collected by vacuum filtration, washed with ethyl acetate, then dried under vacuum at 60 °C overnight to afford 1.9 g (92%) of a white solid. IH-NMR (DMSO) IS-MS, m/e = 382 (M+l) Analysis for C24H28 F 3N3θ5 : Calcd: C, 58.18; H, 5.70; N, 8.48; Found: C, 58.19; H, 5.78; N, 8.27. HPLC Analysis (Method C) : >99%, RT=20.40 min. Except as otherwise noted, Examples 258-266 were prepared from (R) -N- [2- (4-methoxybenzoylamino) -2 -phenylethyl] - piperidine-4 -carboxamide trifluoroacetate and the indicated aldehyde or ketone using the reductive alkylation method described in Example 258 (Alkylation Method A) . Example 258. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -1-isopropyl- piperidine-4 -carboxamide (Alkylation Method A) (R) -N- [2- (4-Methoxybenzoylamino) -2- phenylethyl] piperidine-4 -carboxamide trifluoroacetate (0.50 g, 1.0 mmol), acetone (4.5 mL, 61 mmol), acetic acid (0.28 mL, 4.9 mmol), and sodium cyanoborohydride (0.32 g, 5.1 mmol) were combined in methanol, and stirred. After 4 h, TLC (79% CH 2 C1 2 , 19% methanol, 1% NH 4 OH) indicated reaction completion. The solution was diluted with methanol (100 mL) , and passed through H + form ion exchange resin (Varian SCX cartridge, Catalog #1225-6035) washed with methanol, and then with 2 M NH3 in methanol to collect the product. The product was recrystallized from methanol and ether to afford 0.30 g (70%) of a white crystalline solid. IH-NMR (DMSO) IS-MS, m/e = 424 (M+l) Analysis for C25H33N3O3 • 0.75H2O: Calcd: C, 68.70; H, 7.96; N, 9.61; Found: C, 68.73; H, 7.68; N, 9.29. HPLC Analysis (Method C) : >99% RT=18.19 min. Examples 259-262 were purified by passing a solution through a silica gel column, eluting with 200:10:1 methylene chloride, methanol, and concentrated ammonium hydroxide. Example 259. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -1- cyclopentylpiperidine-4-carboxamide Prepared from cyclopentanone (44%) . IH-NMR (DMSO) IS-MS, m/e = 450 (M+l) Analysis for C27H35N3O3 • 0.25H 2 0: Calcd: C, 71.42; H, 7.88; N, 9.25; Found: C, 71.21; H, 7.93; N, 9.18. HPLC Analysis (Method C) : >99%, RT=18.84 min. Melting Point = 253-257 °C Example 260 . (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -1- cyclohexylpiperidine-4 -carboxamide Prepared from cyclohexanone (65%) . IH-NMR (DMSO) IS-MS, m/e = 464 (M+l) Analysis for C28H37N3O3 • 1.0H O: Calcd: C, 69.83; H, 8.16; N, 8.72; Found: C, 69.64; H, 7.84; N, 8.90. HPLC Analysis (Method C) : >99%, RT=19.13 min. Melting Point = 239-243 °C. Example 261. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -1-ethyl- piperidine-4 -carboxamide Prepared from acetaldehyde (36%) . IH-NMR (DMSO) IS-MS, m/e 410 (M+l) Analysis for C24H 31 N 3 θ3: Calcd: C, 70.39; H, 7.63; N, 10.26; Found: C, 70.06; H, 7.67; N, 10.00. HPLC Analysis (Method D) : 96.9%, RT=16.04 min. Melting Point = 245-251 °C. Example 262. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -1- (1-methyl- piperidin-4-yl) piperidine-4-carboxamide Prepared from l-methylpiperid-4-one (27%) . IH-NMR (DMSO) IS-MS, m/e 479 (M+l) Analysis for C 2 8 H 38 N 4°3 ' ° • 5H 2 0: Calcd : C , 69 . 61 ; H , 8 . 03 ; N , 11 . 60 ; Found: C, 69.72; H, 8.11; N, 11.48. HPLC Analysis (Method D) : 97.0%, RT=15.42 min. Melting Point = 252-259 °C. (No example for Examples 263-264.) Examples 265-266 were purified by passing a solution through a silica gel column, eluting with 200:10:1 methylene chloride, methanol, and concentrated ammonium hydroxide. Example 265. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -1- (3 -pyridinylmethyl) piperidine-4 -carboxamide Prepared from pyridine-3 -carboxaldehyde (68%) . IH-NMR (DMSO) CI-MS, m/e = 473 (M+l) HPLC Analysis (Method D) : 92.7%, RT=15.39 min. Example 266. (R) -N- [2- (4-Methoxybenzoylamino) -2 -phenylethyl] -1- (4 -pyridinylmethyl) piperidine-4 -carboxamide Prepared from pyridine-4 -carboxaldehyde (63%) . IH-NMR (DMSO) CI-MS, m/e = 473 (M+l) HPLC Analysis (Method D) : 89.2%, RT=15.33 min. Example 267. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4-piperidinyl- methyl) piperazine trifluoroacetate 1- [D- (+) -Benzyloxycarbonylphenylglycinyl] - (4-tert-butoxycarbonyl) piperazine. (Coupling Method A) D- (+) -Benzyloxycarbonylphenylglycine (58.0 g, 203 mmol) and 1-Boc-piperazine (41.7 g, 224 mmol) were dissolved in DMF (1 L) and cooled to approximately -15 °C in an ice-methanol bath. Diethyl cyanophosphonate (37.0 mL, 244 mmol) was slowly added to the mixture. Triethylamine (59.4 mL, 426 mmol) was added dropwise to the solution. The mixture was stirred at -15 °C for 2 h and was allowed to gradually warm to room temperature overnight. The mixture was diluted with ethyl acetate and water. The layers were separated, and the water layer extracted with ethyl acetate. The organic layers were combined, washed with 10% citric acid (2 x 500 mL) and brine, dried (Na 2 SU 4 ) , filtered and concentrated under vacuum. The crude product was filtered through a plug of silica gel (1.2 kg) using 1:1 hexanes :ethyl acetate as eluent to provide 1- [D- (+) -benzyl- oxycarbonylphenylglycmyl] -4- ( ert-butoxycarbonyl) piperazine (69.9 g, 76%) as a colorless oil. IH-NMR (CDC1 3 ) API-MS, m/e = 454 (M+l) 1- [D- (+) -Phenylglycinyl] -4- (tert-butoxycarbonyl) piperazine 1- [D- (+) -Benzyloxycarbonylphenylglycinyl] -4- ( ert-butoxy- carbonyl) piperazine (69.5 g, 153 mmol) was dissolved in ethanol (500 mL) . The mixture was degassed with nitrogen and Pd/C (6.8 g) was added. Hydrogen was bubbled through the mixture for 1 h, and it was maintained under a hydrogen atmosphere for 16 h. The Pd/C was removed by filtration through cellulose powder. The filter cake was rinsed with ethanol and ethyl acetate. The filtrate was concentrated under vacuum to give 1- [D- (+) -phenylglycinyl] -4- ( ert- butoxycarbonyl) piperazine (45.3 g, 93%) as a light yellow solid. IH-NMR (CDCI3) API-MS, m/e = 320 (M+l) 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (tert-butoxycarbonyl) piperazine (Acylation Method B) 1- [D- (+) -phenylglycinyl] -4- ( ert- butoxycarbonyl) piperazine (42.0 g, 131.5 mmol) was dissolved in 1,4-dioxane (420 mL) and water (210 mL) and was cooled to 10 °C. Potassium carbonate (36.4 g, 263 mmol) was added, followed by p-anisoyl chloride (24.7 g, 144 mmol) . The mixture was stirred at room temperature overnight. The mixture was diluted with water and ethyl acetate. The layers were separated, and the water layer extracted with ethyl acetate. The organic layers were combined, washed with brine, dried, filtered and concentrated to provide 1- (4 -methoxybenzoyl-D-phenylglycinyl) - (4- ert-butoxycarbonyl) piperazine (58.7 g, 98%) as an off-white solid. IH-NMR (CDCI3) API-MS, m/e = 454 (M+l) 1- (4 -Methoxybenzoyl-D-phenylglycinyl) piperazine trifluoroacetate 1- (4-Methoxybenzoyl-D-phenylglycinyl) - (4-tert-butoxy- carbonyl) piperazine (20.0 g, 44.1 mmol) was dissolved in dichloromethane (50 mL) and anisole (20 mL) . To this vigorously stirred mixture was added trifluoroacetic acid (50 mL) . The mixture was stirred for 25 min at room temperature. The solvents were removed under vacuum. The residue was triturated in ether and sonicated for 60 min. The solid was collected by filtration and dried in a vacuum pistol overnight to provide 1- (4-methoxybenzoyl-D-phenyl- glycinyl) piperazine trifluoroacetate (18.2 g, 88%) as a light yellow solid. IH-NMR (CD 3 OD) API-MS, m/e = 354 (M+l) 1-Boc-isonipecotic acid Isonipecotic acid (15.0 g, 116 mmol) was dissolved in THF (300 mL) , water (150 mL) and 6 N NaOH (40 mL) . Di-tert- butyl dicarbonate (26.6 g, 122 mmol) was added and the mixture stirred overnight. The mixture was diluted with water and ethyl acetate, and the layers separated. The water layers were extracted with ethyl acetate, and the organic layers discarded. The water layer was diluted with KHSO4 (2 N, pH~4) and extracted with ethyl acetate. The organic layer was washed with brine, dried (Na2Sθ4) , filtered and concentrated to provide 1-Boc-isonipecotic acid (23.9 g, 90%) as a white solid. IH-NMR (CDCI3) API-MS, m/e = 230 (M+l) l-Boc-piperidine-4 -methanol 1-Boc-isonipecotic acid (10.0 g, 214 mmol) was dissolved in THF (400 mL) and cooled to 0 °C. A solution of BH 3 -THF (180 mL, 1 N in THF, 180 mmol) was added slowly. The mixture stirred for 1 h at 0 °C and was allowed to warm to room temperature for 12 h. The mixture was carefully quenched with water and diluted with ethyl acetate. The water layer was extracted with ethyl acetate. The organic layers were combined, washed with brine, dried (Na2Sθ4) , filtered and concentrated to provide l-Boc-piperidine-4- methanol (7.98 g, 85%) as a white solid. IH-NMR (CDC13) API-MS, m/e = 220 (M+l) 1-Boc-piperidine-4-carboxaldehyde Dimethyl sulfoxide (3.5 mL, 48.7 mmol) was dissolved in dichloromethane (100 mL) and was cooled to -78 °C. Oxalyl chloride (3.65 mL, 41.8 mmol) was added. The mixture stirred for 30 min. To this solution was added a solution of l-Boc-piperidine-4-methanol (7.5 g, 34.8 mmol) in dichloromethane (15 mL) , and the mixture stirred for 1 h. Triethylamine (9.7 mL, 69.6 mmol) was added slowly and the mixture stirred at -78 °C for 30 min and warmed to room temperature over the course of 1 h. The mixture was diluted with water and the layers separated. The water layer was extracted with dichloromethane and the organic layers combined, dried (Na2 04) , filtered and concentrated to provide l-Boc-piperidine-4 -carboxaldehyde (6.75 g, 91%) as a yellow oil . IH-NM (CDC13) API-MS, m/e = 214 (M+l) 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (l-Boc-piperidin-4- ylmethyl) piperazine (Alkylation Method B) Using Alkylation Method A, except using sodium triacetoxyborohydride in 1, 2-dichloroethane, 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4- (l-Boc-piperidin-4- ylmethyl) piperazine was prepared from 1- (4 -methoxybenzoyl-D- phenylglycinyl) piperazine trifluoroacetate and l-Boc- piperidine-4 -carboxaldehyde (85%) . IH-NMR (CDCI3) 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4 -piperidinyl- methyl) piperazine trifluoroacetate. Using Deprotection Method A, the title compound was prepared from 1- (4 -methoxybenzoyl -D-phenylglycinyl) -4- (1-Boc- piperidin-4-ylmethyl) piperazine (90%) . Melting Point = 70-72 °C with decomposition IR(KBr) IH-NMR (CD 3 OD) API-MS, m/e = 451 (M+l) Analysis for C26H34N4O3 • 2.5TFA- 0.4H 2 0: Calcd: C, 50.12; H, 5.06; N, 7.54; Found: C, 49.81; H, 5.33; N, 7.39. HPLC Analysis (Method B) : 97.1% RT=14.3 min. Examples 268 to 272 Unless otherwise indicated, using Alkylation Method A or B, the title compounds were prepared from 1- (4 -methoxybenzoyl- D-phenylglycinyl) -4- (4 -piperidinylmethyl) piperazine trifluoroacetate and the indicated aldehyde or ketone. Example 268. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (1-methylpiperidin- 4 -ylmethyl) piperazine hydrochloride Prepared from paraformaldehyde using Method A (56%) . IR (KBr) IH-NMR (CD3OD) CI-MS, m/e = 465 (M+l) Example 269. 1- (4 -Methoxybenzoyl-D-phenylglycinyl) -4- (1-isopropyl- piperidin-4-ylmethyl) piperazine hydrochloride Prepared from acetone using Method A (72%) . Melting Point = 172-180 °C with decomposition IR (KBr) IH-NMR (CD 3 OD) CI-MS, m/e = 493 (M+l) Analysis for C29H40N4O3 ■ 3HC1 : Calcd: C, 55.85; H, 7.34; N, 8.98; Found: C, 55.63; H, 7.32; N, 8.66. HPLC Analysis (Method B) : 98.2% RT=14.4 min. Example 270. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- [3- (3-pyridinyl) - propyl) piperazine hydrochloride Prepared from pyridine-3-propionaldehyde (prepared as described below) using Method B (72%) . IH-NMR (CD3OD) CI-MS, m/e = 473 (M+l) Pyridine-3-propionaldehyde (Oxidation Method A) 1, 1, 1-Triacetoxy-l , 1-dihydro-l, 2- benziodoxol-3 (IH) -one (5.4 g, 12.7 mmol) was suspended in dichloromethane (45 mL) . 3-Pyridinepropanol (1.59 g, 11.6 mmol) as a solution in dichloromethane (35 mL) was added slowly. The mixture stirred for 3 h at room temperature. The mixture was diluted with saturated aqueous NaHCC.3 and ether. The mixture was stirred for 10 min and was diluted with sodium thiosulfate (2 N) and stirred until the solids dissolved. The layers were separated, and the water layer was extracted with ether. The organic layers were combined, washed with water and brine, dried (Na2Sθ4) , filtered and concentrated to provide pyridine-3 -propionaldehyde (1.03 g, 66%) as a yellow oil. IH-NMR (CDCI3) Example 271. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- [3- (4-pyridinyl) - propyl] piperazine hydrochloride. Prepared from pyridine-4-propionaldehyde (prepared as described below) using Method A; the hydrochloride salt was prepared using HCl (2 M) in diethyl ether (76%) . IH-NMR (CD 3 OD) CI-MS, m/e = 473 (M+l) Pyridine-4 -propionaldehyde Prepared from 4-pyridinepropanol using Oxidation Method A (80%) . IH-NMR (CDCI3) Example 272. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (2 -cyclopentyl- ethyl) piperazine hydrochloride hydrate The free base was prepared from cyclopentylacetaldehyde (prepared as described below) using Method B (58%) . IH NMR (CDCI3) To a stirred solution of 1- (4 -methoxybenzyl -D-phenylglycinyl) -4- (2-cyclopentylethyl) piperazine (260 mg, 0.58 mmol) in ether (10 mL) and methylene chloride (1 mL) was added hydrogen chloride as a 2 N solution in ether (about 2 mL) , and the resulting precipitate was filtered to give 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4- (2-cyclopentylethyl) piperazine hydrochloride as a pale yellow solid. IH NMR (CD3OD) IS-MS, m/e = 450 (M+l) Analysis for C27H35N3O3 -HCl • 0.5H 2 0: Calcd: C, 65.51; H, 7.53; N, 8.49; Found: C, 65.67; H, 7.58; N, 8.13. HPLC Analysis (Method E) : >99%, RT=15.84 Melting Point = 190-192 °C Cyclopentylacetaldehyde Using Oxidation Method A, the title compound was prepared from 2-cyclopentylethanol and used with trace amounts of ether and methylene chloride present due to volatility of product . IH NMR (CDC1 3 ) Example 273. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (3-pyrrolidinyl) - piperazine trifluoroacetate. (R) - (+) -l-Boc-3-pyrrolidinol To a stirred solution of (R) - (+) -3-pyrrolidinol (2 g, 22.96 mmol) in tetrahydrofuran (60 mL) and water (30 mL) was added di- tert-butyl dicarbonate (5.27 g, 24.15 mmol) and 3 N sodium hydroxide (16 mL) , and the resulting solution was stirred for 6 h. Another portion of di- tert-butyl dicarbonate (0.74 g, 0.34 mmol) was added and the solution was stirred overnight. The reaction was diluted with water (40 mL) and extracted with ethyl acetate (2 x 150 mL) . The combined organic extracts were washed with 2 N potassium hydrogen sulfate (200 L) , saturated sodium bicarbonate (2 x 150 mL) , brine (150 mL) and dried over magnesium sulfate. Removal of solvent in vacuo gave (R) - (+) -l-Boc-3- pyrrolidinol (4.21 g, 98%) as a yellow oil. IH-NMR (CDCI3) 1-Boc-3 -pyrrolidinone Using Oxidation Method A, the title compound was prepared from (R) - (+) -l-Boc-3-pyrrolidinol (85%). IH NMR (CDC1 3 ) 1- (4-Methoxybenzyl-D-phenylglycinyl) -4- (l-Boc-3- pyrrolidinyl) piperazine Using Alkylation Method B, the title compound was prepared (69%) from 1- (4 -methoxybenzyl-D-phenylglycinyl) piperazine trifluoroacetate and l-Boc-3-pyrrolidinone. IH NMR (CDCI3) 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (3-pyrrolidinyl) - piperazine trifluoroacetate. Using Deprotection Method A, the title compound was prepared from 1- (4 -methoxybenzyl -D-phenylglycinyl) -4- (l-Boc-3- pyrrolidinyl) piperazine . IH NMR (CD3OD) Example 274. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- [2- (4-pyridinyl) - ethyl] piperazine l-Boc-4- [2- (4-pyridinyl) ethyl] piperazine 1-Boc-piperazine (4.0 g, 21.5 mmol), 4-vinylpyridine (2.94 g, 27.9 mmol), and acetic acid (1.29 g, 21.5 mmol) were mixed in ethanol and heated to reflux for 48 h. The mixture was cooled to room temperature and concentrated under vacuum to provide l-Boc-4- [2- (4-pyridinyl) ethyl] - piperazine (2.9 g, 45%) as an off white solid. The product was used without further purification. IH-NMR (CDC13) CI-MS, m/e = 292 (M+l) 1- [2- (4-Pyridinyl) ethyl] piperazine hydrochloride (Deprotection Method B) l-Boc-4- [2- (4-pyridinyl) ethyl] - piperazine (1.0 g, 3.43 mmol) was dissolved in ethyl ether. Ethyl acetate (15 mL) saturated with HCl was added, and the mixture stirred for 30 min at room temperature. The mixture was concentrated under vacuum and provided l-[2-(4- pyridinyl) ethyl] piperazine hydrochloride (900 mg, 87%) as a tan solid. IH-NMR (CD 3 OD) CI-MS, m/e = 192 (M+l) 1- (D-Boc-phenylglycinyl) -4- [2- (4-pyridinyl) ethyl] piperazine Using Coupling Method A, the title compound was prepared from 1- [2- (4-pyridinyl) ethyl] piperazine and Boc-D-phenylglycine (95%). IH-NMR (CDCI3) CI-MS, m/e = 425 (M+l) 1- (D-Phenylglycinyl) -4- [2- (4-pyridinyl) ethyl] piperazine hydrochloride Using Deprotection Method B, the title compound was prepared from 1- (D-Boc-phenylglycinyl) -4- [2- (4-pyridinyl) ethyl] - piperazine (89%) . IH-NMR (CD3OD) CI-MS, m/e = 325 (M+l) 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- [2- (4-pyridinyl) - ethyl] piperazine Using Acylation Method B, the title compound was prepared from 1- (D-phenylglycinyl) -4- [2- (4-pyridinyl) ethyl] piperazine hydrochloride and p-anisoyl chloride (70%) . IH-NMR (CDCI3) CI-MS, m/e = 459 (M+l) HPLC Analysis (Method E) : 99.7%, RT=10.98 min. Examples 275 to 276 Using Alkylation Method B, the title compounds were prepared from 1- (4 -methoxybenzoyl -D-phenylglycinyl) -4- (3 -pyrrolidinyl) piperazine trifluoroacetate and the indicated aldehyde or ketone. Example 275. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (1-methylpyrrolidin- 3 -yl)piperazine Prepared from paraformaldehyde (20%) . 1H-NMR(CDC1 3 ) Example 276. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (1-isopropyl- pyrrolidin-3 -yl) piperazine . Prepared from acetone (59%) . IH-NMR (CDCI3) The following analytical methods apply to Examples 277-336. /Analytical RPHPLC Method 1 = Vydac C18, linear gradient of 90/10 - 50/50 (0.1% TFA in water / 0.1% TFA in acetonitrile) over 40 min, 1 mL/min. Analytical RPHPLC Method 2 = Vydac C18, linear gradient of 85/20 - 40/60 (0.1% TFA in water / 0.1% TFA in acetonitrile) over 40 min, 1 mL/min. Examples 277 to 290 Unless otherwise indicated, the products of Examples 277 through 290 were obtained from the indicated acid and 1-D-phenylglycinyl-l' -methyl-4, 4 ' -bispiperidine using the procedure described in Example 277 (Coupling Method B) . Example 277. 1- (2-Chloropyridine-5-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine (Coupling Method B) To a stirring solution of 1- [3- (dimethylamino) propyl] -3-ethylcarbodiimide hydrochloride (0.20 g, 1.0 mmol) and 1-hydroxybenzotriazole hydrate (0.15 g, 1.1 mmol) in DMF (3 mL) was added 2-chloropyridine- 5-carboxylic acid (0.14 g, 0.89 mmol) followed by a solution of 1-D-phenylglycinyl-l' -methyl-4, 4' -bispiperidine (0.25 g, 0.80 mmol) in DMF (2 mL) . After stirring for 18 h, the solvent was removed in vacuo and the residue was partitioned between dichloromethane and 1 N sodium hydroxide. The aqueous phase was separated, extracted twice with dichloromethane, and the combined organic phases were dried with MgSθ4, filtered and concentrated in vacuo. The resulting solid was dissolved in a minimum amount of dichloromethane and chromatographed over silica gel, eluting with 10% methanol (containing 2 N ammonia) in dichloromethane through 15% methanol (containing 2 N ammonia) in dichloromethane. The product containing fractions were combined and concentrated in vacuo to give 0.258 g (71%) of a white solid. IH-NMR IS-MS, m/e 455.0 (M+l) Analysis for C25H31N4O2CI • 0.4H 0 : Calcd: C, 64.96; H, 6.93; N, 12.13; Found: C, 64.68; H, 6.72; N, 12.02. Analytical RPHPLC, Method 1, RT = 21.28 min (98%) Example 278. 1- (5-Chloropyridine-2-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine Prepared from 2-chloropyridine-5-carboxylic acid (61%) . IH-NMR IS-MS, m/e 454.9 (M+l) Analysis for C25H 31 N4θ 2 Cl • 0.4H 0: Calcd: C, 64.96; H, 6.93; N, 12.12; Found: C, 64.75; H, 6.64; N, 12.00. Analytical RPHPLC, Method 1, RT = 27.23 min (100%) Example 279. 1- (3 -Cyano-4-fluorobenzoyl-D-phenylglycinyl) -1' -methyl-4,4' - bispiperidine Prepared from 3-cyano-4-fluorobenzoic acid (66%). IH-NMR IS-MS, m/e 463.0 (M+l) Analysis for C 7H3iN θ2F- 0.3H 2 0: Calcd: C, 69.30; H, 6.81; N, 11.97; Found: C, 68.91; H, 6.58; N, 11.77. Analytical RPHPLC [Vydac C18, linear gradient of 85/15 - 45/55 (0.1% TFA in water / 0.1% TFA in acetonitrile) over 40 min, 1 mL/min] RT = 21.54 (99%). Example 280. 1- (5-Chlorobenzo [b] thiophene-2-carbonyl-D-phenylglycinyl) - 1' -methyl-4,4' -bispiperidine Prepared from 5-chlorobenzo [b] thiophene-2 -carboxylic acid (38%) . IH-NMR IS-MS, m/e 509.9 (M+l) Analysis for C28 H 32 N 3°2 S 1 ' ° • 3H 2 0: Calcd: C, 65.24; H, 6.37; N, 8.15; Found: C, 65.01; H, 6.12; N, 8.07. Analytical RPHPLC, Method 1, RT = 36.08 min (99%) Example 281. 1- (2-Benzo [b] thiophenecarbonyl-D-phenylglycinyl) -1' -methyl- 4, 4' -bispiperidine Prepared from 2-benzo [b] thiophenecarboxylic acid (82%). IH-NMR IS-MS, m/e 475.9 (M+l) Analysis for C28H33N3O2S • 0.4H 2 0: Calcd: C, 69.65; H, 7.06; N, 8.70; Found: C, 69.45; H, 6.90; N, 8.58. Analytical RPHPLC, Method 2, RT = 22.30 min (100%) Example 282. 1- (6-Chlorobenzo [b] thiophene-2-carbonyl-D-phenylglycinyl) - 1' -methyl-4, 4' -bispiperidine Prepared from 6-chlorobenzo [b] thiophene-2 -carboxylic acid (77) . IH-NMR IS-MS, m/e 509.9 (M+l) Analysis for C 8 H 32 N 3°2 SC1 ' ° • 3H 2 0: Calcd: C, 65.24; H, 6.37; N, 8.15; Found: C, 64.97; H, 6.23; N, 8.07. Analytical RPHPLC, Method 2, RT = 27.62 min (100%) Example 283 . 1- (Indole-2-carbonyl-D-phenylglycinyl) -1' -methyl-4,4' - bispiperidine Prepared from 2-indolecarboxylic acid (57%) . IH-NMR IS-MS, m/e 459.0 (M+l) Analysis for C 2 8 H 34 N 4θ2 * ° • 4H 2 0: Calcd: C, 71.10; H, 7.59; N, 11.85; Found: C, 70.82; H, 7.25; N, 11.74. Analytical RPHPLC, Method 1, RT = 29.60 min (99%) Example 284. 1- (l-Methylindole-2-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine Prepared from l-methylindole-2-carboxylic acid (43%) . IH-NMR IS-MS, m/e 473.0 (M+l) Analytical RPHPLC, Method 2, RT = 22.20 min (98%) Example 285. 1- (Benzofuran-2 -carbonyl-D-phenylglycinyl) -1' -methyl-4,4' - bispiperidine Prepared from 2-benzofurancarboxylic acid (50%) . IH-NMR IS-MS, m/e 460.0 (M+l) Analytical RPHPLC, Method 1, RT = 27.59 min (100%) Example 286. 1- (3-Methylbenzofuran-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine Prepared from 3 -methylbenzofuran-2 -carboxylic acid (47%) . IH-NMR IS -MS , m/e 474 . 1 (M+l ) Analytical RPHPLC, Method 1, RT = 31.31 min (95%) Example 287. 1- (5-Methylbenzofuran-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine Prepared from 5-methylbenzofuran-2-carboxylic acid (45%) . IH-NMR IS-MS, m/e 474.3 (M+l) Analytical RPHPLC, Method 1, RT = 30.91 min (100%) Example 288. 1- (6-Methoxybenzofuran-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine Prepared from 6-methoxybenzofuran-2-carboxylic acid (50%) . IH-NMR IS-MS, m/e 490.0 (M+l) Analytical RPHPLC, Method 1, RT = 29.26 min (100%) Example 289. 1- (5-Chlorobenzofuran-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine Prepared from 5-chlorobenzofuran-2-carboxylic acid (59%) . IH-NMR IS-MS, m/e 493.9 (M+l) Analysis for C28 H 32 N 3°3 1 ' ° • 5H 2 0: Calcd: C, 66.85; H, 6.61; N, 8.35; Found: C, 66.46; H, 6.28; N, 8.25. Analytical RPHPLC, Method 1, RT = 34.86 min (100%) Example 290 . 1- (2-Aminobenzimidazole-5-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine Prepared from 2-amino-5-carboxybenzimidazole hydrochloride (32%) . IH-NMR IS-MS, m/e 475.2 (M+l) /Analytical RPHPLC [Vydac C18, linear gradient of 98/2 - 58/42 (0.1% TFA in water / 0.1% TFA in acetonitrile) over 40 min, 1 mL/min] RT = 24.56 (90%). Example 291. 1- (3-Aminobenzisoxazole-5-carbonyl-D- phenylglycine) -1' -methyl-4 , 4 ' -bispiperidine To a stirring solution of acetoxime (98 mg, 7.1 mmol) in DMF (5 mL) was added a 1 M solution of potassium tert-butoxide (1.3 mL, 1.3 mmol) in THF. After 2 min, 1- (3-cyano-4- fluorobenzoyl-D-phenylglycinyl) -1' -methyl-4,4' -bispiperidine (303 mg, 0.65 mmol) was added; and, after another hour, the solvent was partially removed and the residue was partitioned between brine and dichloromethane. The layers were separated and the aqueous phase was extracted another two times with dichloromethane. The combined organics were dried (MgS04) , filtered and concentrated in vacuo. IS-MS, m/e 516.0 (M+l) The residue was then dissolved in ethanol (3.6 mL) and 1 N HCl was added. The stirring solution was heated to reflux. After 5 h, the heating mantle was removed and after cooling, the solution was diluted ethyl acetate and water. The pH of the aqueous phase was adjusted to 11 with 2 N sodium hydroxide and extracted twice with dichloromethane. The combined dichloromethane extracts were dried (MgS04) , filtered and concentrated in vacuo. The resulting solid was dissolved in a minimum amount of dichloromethane and chromatographed over silica gel, eluting with 2% methanol (containing 2 N ammonia) in dichloromethane through 10% methanol (containing 2 N ammonia) in dichloromethane. The product containing fractions were combined and concentrated in vacuo to give 89 mg (29%) of an off-white solid. IH-NMR IS-MS, m/e 476.3 (M+l) Analytical RPHPLC, Method 1, RT = 19.55 min (99%) Examples 292 to 303 Preparation of Starting Materials 1- (Boc-D-phenylglycinyl) -4-hydroxypiperidine (Coupling Method C) To a stirring solution of 1-hydroxy- 7-azabenzotriazole (10.24 g, 75.2 mmol) and EDCI (14.42 g, 75.2 mmol) in DMF (160 mL) was added a solution of Boc-D- phenylglycine (18.9 g, 75.2 mmol) in DMF (80 mL) . After 10 min, 4 -hydroxypiperidine (6.85 g, 67.7 mmol) was added. After stirring over night, the solvent was evaporated in vacuo and the residue was partitioned between ethyl acetate and water. The organic phase separated and washed with saturated aqueous NaHCθ3 , followed by brine, dried over MgS04, filtered and concentrated in vacuo. Two-thirds of this material was dissolved in a minimum amount of dichloromethane and chromatographed over silica gel, eluting with a gradient of dichloromethane through 1 : 1 dichloromethane/ethyl acetate. The product containing fractions were combined and concentrated in vacuo to give 15.71 g (94%) of a white foam. IH-NMR IS-MS, m/e 335.1 (M+l) Analysis for Cχ8 H 26 N 2°4 0: Calcd: C, 64.65; H, 7.84; N, 8.37; Found: C, 64.40; H, 7.77; N, 8.12. 1- (D-phenylglycinyl) -4 -hydroxypiperidine (Deprotection Method D) To a stirring solution of 1- (Boc-D- phenylglycinyl) -4 -hydroxypiperidine (5 g, 15 mmol) in dichloromethane (290 mL) was added anisole, (8 mL) followed by trifluoroacetic acid (29 mL) . After stirring for 4 h, the solvent was concentrated in vacuo and the residue was suspended with stirring in diethyl ether. After 1 h, the mixture was filtered and the solid was partitioned between ethyl acetate and saturated aqueous NaHCθ3. The organic phase was washed with brine, dried with MgSθ4 , filtered and concentrated to give 0.41 g of white solid. The combined aqueous phase was back extracted with 3:1 chloroform/ - isopropanol and this organic phase was separated, dried with MgS04, filtered and concentrated in vacuo to give 1.6 g of white solid. The two crops of solid were combined to give 2.02 g (90%) of the title compound. IH-NMR IS-MS, m/e 235.1 (M+l) 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4 -hydroxypiperidine To a stirring solution of 1- [3- (dimethylamino) propyl] - 3-ethylcarbodiimide hydrochloride (1.4 g, 7.4 mmol), 1-hydroxybenzotriazole hydrate (1.0 g, 7.4 mmol) and N,N-diisopropylethylamine (1.4 mL) in DMF (20 mL) was added a solution of 1- (D-phenylglycinyl) -4 -hydroxypiperidine (2.0 g, 7.38 mmol) in DMF (10 mL) followed by a solution of -methoxybenzoic acid (1.0 g, 6.7 mmol) in DMF (10 mL) . After stirring overnight at room temperature, the solvent was removed in vacuo and the residue was partitioned between ethyl acetate and water. The organic phase was washed again with water followed by saturated aqueous NaHCθ3 (2X) and brine, then dried with MgSθ4 , filtered and concentrated in vacuo to give 2.4 g of off-white solid. A portion of this material (2.0 g) was dissolved in a minimal amount of dichloromethane and chromatographed over silica gel, eluting with a gradient of dichloromethane through 50% ethyl acetate/dichloromethane . The product-containing fractions were combined and concentrated in vacuo to give 1.3 g (60%) of a white foam. IH-NMR IS-MS, m/e 369.2 (M+l) Analysis for C21H24N2O4: Calcd: C, 68.46; H, 6.57; N, 7.60; Found: C, 67.88; H, 6.73; N, 7.33. Analytical RPHPLC, Method 1, RT = 24.24 min (100%) 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4-oxopiperidine (Oxidation Method B) To a stirring solution of oxalyl chloride (0.26 mL, 3 mmol) in dichloromethane (6.5 mL) at -50 °C, was added a solution of DMSO (0.43 mL, 6 mmol) in dichloromethane (1.3 mL) . After 3 min, a solution of 1- (4 -methoxybenzoyl -D-phenylglycinyl) -4 -hydroxypiperidine (1.0 g, 2.7 mmol) in dichloromethane (4 mL) was added and the solution was allowed to warm to -20 °C over 45 min. Triethylamine (2 mL) was then added and the solution was allowed to warm to room temperature. The solution was then diluted with dichloromethane and water and the layers were separated. The organic phase was washed with brine, dried over MgSθ , filtered and concentrated in vacuo. The residue was dissolved in a minimum amount of dichloromethane and chromatographed over silica gel, eluting with a gradient of dichloromethane through 50% ethyl acetate/dichloromethane. The product containing fractions were combined and concentrated in vacuo to give 0.77 g (78%) of a white foam. IH-NMR IS-MS, m/e 367.2 (M+l) Analysis for C2iH22 N 2°4 : Calcd: C, 68.84; H, 6.05; N, 7.65; Found: C, 68.33; H, 6.01; N, 7.27. Analytical RPHPLC, Method 1, RT = 25.52 min (100%) General Procedure: Unless otherwise indicated, the product of Examples 292-303 was obtained from 1- (4 -methoxybenzoyl-D- phenylglycinyl) -4-oxopiperidine and the indicated amine using the alkylation procedure described for Example 292 (Alkylation Method C) . Example 292. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (1-pyrrolidinyl) - piperidine (Alkylation Method C) To a stirring solution of 1- (4 -methoxybenzoyl-D-phenylglycinyl) -4-oxopiperidine (50 mg, 0.14 mmol) and pyrrolidine (0.011 mL, 0.13 mmol) in 1, 2-dichloroethane (1 mL) was added sodium triacetoxyborohydride (45 mg, 0.21 mmol). After stirring overnight, the mixture was loaded onto an SCX column (pretreated with a 5% glacial acetic acid in methanol solution) , rinsed with methanol (2 column volumes) and eluted with a 30% 2 N ammonia/methanol in dichloromethane solution. The solution was concentrated in vacuo. The product containing fractions were combined and concentrated in vacuo to give 48 mg (87%) of the title compound. IH-NMR IS-MS, m/e 422.0 (M+l) Analytical RPHPLC, Method 1, RT = 21.02 min (100%) Example 293. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (1-piperidinyl) - piperidine Prepared from piperidine (49%) . IH-NMR IS-MS, m/e 436.0 (M+l) Analytical RPHPLC, Method 1, RT = 22.14 min (100%) Example 294. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4-methylpiperidin- 1-yl) piperidine Prepared from 4-methylpiperidine (78%) . IH-NMR IS-MS, m/e 450.0 (M+l) Analytical RPHPLC, Method 1, RT = 24.06 min (100%) Example 295. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4-methylpiperazin- 1-yl) piperidine Prepared from 1-methylpiperazine (98%) . IH-NMR IS-MS, m/e 451.0 (M+l) Analytical RPHPLC, Method 1, RT = 18.66 min (99%) Example 296 . 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4-ethylpiperazin-l- yl) piperidine Prepared from 1-ethylpiperazine (76%) . IH-NMR IS-MS, m/e 465.0 (M+l) Analytical RPHPLC, Method 1, RT = 19.11 min (100%) Example 297. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4-isopropyl- piperazin-1-yl) piperidine Prepared from 1-isopropylpiperazine (83%) . IH-NMR IS-MS, m/e 479.2 (M+l) Analysis for C 2 8 H 38 N 4°3 ' ° • 3H 2 0: Calcd: C, 69.48; H, 8.04; N, 11.58; Found: C, 69.22; H, 7.91; N, 11.34. Analytical RPHPLC, Method 1, RT = 19.56 min (99%) Example 298. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (hexahydro-1, 4- diazapin-1-yl) piperidine hydrochloride IH-NMR IS-MS, m/e 451.0 (M+l) Analytical RPHPLC, Method 1, RT = 16.86 min (100%) Example 299. 1- (4 -Methoxybenzoyl-D-phenylglycinyl) -4- [4-methyl- (hexahydro-1, 4-diazapin-l-yl) ] piperidine Prepared from 4-methyl-hexahydro-l, 4-diazapine (63%). IH-NMR IS-MS, m/e 465.0 (M+l) Analytical RPHPLC, Method 1, RT = 18.86 min (98%) Example 300. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (3-pyridylamino) - piperidine Prepared from 3-aminopyridine (25%) . IH-NMR IS-MS, m/e 445.0 (M+l) Analytical RPHPLC, Method 1, RT = 23.87 min (100%) Example 301. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- [ (N-methyl-N- benzyl) amino] iperidine Prepared from N-methylbenzylamine (89%) . IH-NMR IS-MS, m/e 472.0 (M+l) Analysis for C29H33N3O3 • 0. IH2O: Calcd: C, 73.58; H, 7.07; N, 8.88; Found: C, 73.39; H, 7.19; N, 9.06. Analytical RPHPLC, Method 1, RT = 26.27 min (98%) Example 302. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- [ (3-pyridylmethyl) amino] piperidine Prepared from 3 -aminomethylpyridine (72%) . IH-NMR IS-MS, m/e 459.0 (M+l) Analysis for C27H30N4O3 • 0.2H 2 0: Calcd: C, 70.17; H, 6.63; N, 12.12; Found: C, 70.00; H, 6.53; N, 12.13. Analytical RPHPLC, Method 1, RT = 16.38 min (100%) Example 303 . 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- [ (4-pyridylmethyl) - amino] piperidine prepared from 4-aminomethylpyridine (46%) . IH-NMR IS-MS, m/e 459.0 (M+l) Analysis for C27H30N4O3 • 0.9H 2 0: Calcd: C, 68.30; H, 6.75; N, 11.80; Found: C, 67.99; H, 6.42; N, 11.59. Analytical RPHPLC, Method 1, RT = 18.36 min (100%) Examples 304 to 314 General Procedure: Unless otherwise indicated, the product of Examples 304-314 was obtained from 1- (4 -methoxybenzoyl-D- phenylglycinyl) piperazine and the indicated aldehyde or ketone using the alkylation procedure described for Example 304 (Alkylation Method D) . Example 304. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (2-pyridylmethyl) - piperazine (Alkylation Method D) To a stirring solution of 1- (4 -methoxybenzoyl-D-phenylglycinyl) piperazine (50 mg, 0.14 mmol) and 2-pyridinecarboxaldehyde (0.020 mL, 23 mg, 0.21 mmol) in 5% acetic acid/methanol (1 mL) was added NaB^CN (20 mg, 0.32 mmol) . After 4 h, the solution was loaded onto an SCX column (pretreated with a 5% glacial acetic acid in methanol solution) , rinsed with methanol (2 column volumes) and eluted with a 30% 2N ammonia/methanol in dichloromethane solution. The solution was concentrated in vacuo and the residue was dissolved in a minimum amount of dichloromethane and chromatographed over silica gel, eluting with dichloromethane, followed by 50% ethyl acetate/dichloromethane, and finally with a gradient of 2%-10% (2 N NH 3 in MeOH) in dichloromethane. The product containing fractions were combined and concentrated in vacuo to give 30 mg (48%) of the title compound. IH-NMR IS-MS, m/e 444.9 (M+l) Analytical RPHPLC, Method 1, RT = 21.70 min (100%) Example 305. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (3-pyridylmethyl) - piperazine Prepared from 3 -pyridine carboxaldehyde (42%) . IH-NMR IS-MS, m/e 444.9 (M+l) Analytical RPHPLC, Method 1, RT = 17.84 min (99%) Example 306. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4-pyridylmethyl) - piperazine Prepared from 4-pyridine carboxaldehyde (45%) . IH-NMR IS-MS, m/e 444.9 (M+l) Analytical RPHPLC, Method 1, RT = 18.36 min (99%) Example 307. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4-phenethylpiperazine Prepared from phenylacetaldehyde (34%) . IH-NMR IS-MS, m/e 458.0 (M+l) Analytical RPHPLC, Method 1, RT = 27.44 min (100%) Example 308 . 1- (4 -Methoxybenzoyl-D-phenylglycinyl) -4- (3 -pentyl) piperazine Prepared from 3-pentanone (88%) . IH-NMR IS-MS, m/e 424.0 (M+l) Analytical RPHPLC, Method 1, RT = 23.62 min (100%) Example 309. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4 -cyclopentyl- piperazine Prepared from cyclopentanone (95%) . IH-NMR IS-MS, m/e 422.0 (M+l) Analytical RPHPLC, Method 1, RT = 20.76 min (100%) Example 310. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (4-methyl- cyclohexyl) piperazine Prepared from 4-methylcyclohexanone (46%) . IH-NMR IS-MS, m/e 450.0 (M+l) Analytical RPHPLC, Method 1, RT = 27.07 min (isomer 1), 27.74 min (isomer 2) . Example 311. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (tetrahydro- thiopyran-4-yl) piperazine Prepared from tetrahydro-4H-thiopyran-4-one (86%) . IH-NMR IS-MS, m/e 453.9 (M+l) Analytical RPHPLC, Method 1, RT = 22.96 min (100%) Example 312 . 1- (4 -Methoxybenzoyl-D-phenylglycinyl) -4- (2-indanyl) - piperazine Prepared from 2-indanone (92%) . IH-NMR IS-MS, m/e 469.9 (M+l) Analytical RPHPLC, Method 1, RT = 26.32 min (100%) Example 313. 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4-benzylpiperazine Prepared from benzaldehyde (87%) . IH-NMR IS-MS, m/e 444.0 (M+l) Analytical RPHPLC, Method 1, RT = 25.78 min (96%) Example 314. 1- (4 -Methoxybenzoyl-D-phenylglycinyl) -4- (cyclohexyl- methyl) piperazine Prepared from cyclohexanecarboxaldehyde (86%) . IH-NMR IS-MS, m/e 450.2 (M+l) Analytical RPHPLC, Method 1, RT = 28.07 min (94%) Examples 315 to 316 Preparation of Starting Materials 1- (Boc-D-Phenylglycinyl) -4-oxopiperidine Using Oxidation Method B, the title compound was prepared from 1- (Boc-D-phenylglycinyl) -4-hydroxypiperidine (44%). IH-NMR IS-MS, m/e 333.0 (M+l) 1- (Boc-D-Phenylglycinyl) -4- (4-methylpiperazin-l-yl) - piperidine Using Alkylation Method C, the title compound was prepared from 1- (Boc-D-phenylglycinyl) -4-oxopiperidine and methylpiperazine (65%) . IH-NMR IS-MS, m/e 417.3 (M+l) Analysis for C23H36N4O3: Calcd: C, 66.32; H, 8.71; N, 13.45; Found: C, 66.25; H, 8.58; N, 13.42. 1-D-Phenylglycinyl-4- (4-methylpiperazin-l-yl) piperidine HCl gas was bubbled through a stirring solution of 1- (Boc-D- phenylglycinyl) -4- (4-methylpiperazin-l-yl)piperidine (1.36 g, 3.26 mmol) in ethyl acetate (150 mL) . A white precipitate was formed immediately, but then went back into solution. After about 5 min, a white precipitate again fell out of solution. After 10 min, the addition of HCl was discontinued and after stirring for a total of 1 h, the mixture was filtered to give 1.38 g (quantitative) of white solid. IH-NMR IS-MS, m/e 317.3 (M+l) Analysis for C 18 H 2 8N4θ- 2.9HC1 • 2.5H 2 0: Calcd: C, 46.27; H, 7.74; N, 11.99; Cl , 22.01; Found: C, 46.06; H, 7.51; N, 11.63; Cl , 21.78. General Procedure: The product of Examples 315-316 was prepared from 1- (D-phenylglycinyl) -4- (4-methylpiperazin- 1-yl) piperidine and the indicated acid using Coupling Method B. Example 315 . 1- (Indole-6-carbonyl-D-phenylglycinyl) -4- (4-methylpiperazin- 1-yl) iperidine Prepared from indole-6-carboxylic acid (66%) . IH-NMR IS-MS, m/e 460.2 (M+l) Analytical RPHPLC, Method 1, RT = 17.83 min (99%) Example 316. 1- (3-Chloroindole— 6-carbonyl-D-phenylglycinyl) -4- (4-methyl- piperazinyl) piperidine Prepared from 3-chloroindole-6-carboxylic acid (69%) . IH-NMR IS-MS, m/e 494.3 (M+l) Analytical RPHPLC, Method 1, RT = 22.99 min (99%) Examples 317 to 320 Preparation of Starting Materials (Cbz-D-phenylglycinyl) piperazine . Using Deprotection Method D, the title compound was prepared from 1- (Cbz-D-phenylglycinyl) -4-Boc-piperazine (85%) IH-NMR IS-MS, m/e 354.2 (M+l) Analysis for C2o H 23 N 3°3 ' ° • 2H 2 0: Calcd: C, 67.28; H, 6.61; N, 11.77; Found: C, 67.10; H, 6.46; N, 11.63. 1- (Cbz-D-phenylglycinyl) -4- (l-methylpiperidin-4-yl) - piperazine Using Alkylation Method C, the title compound was prepared from (Cbz-D-phenylglycinyl) piperazine and 1-methylpiperidin- 4-one (49%) . The product was purified using silica gel chromatography, eluting with a gradient of dichloromethane through 10% (2 N ammonia in methanol) / dichloromethane. IH-NMR IS-MS, m/e 451.3 (M+l) Analysis for C26H34N4O3: Calcd: C, 69.31; H, 7.61; N, 12.43; Found: C, 69.36; H, 7.71; N, 13.14. l-D-Phenylglycinyl-4- (l-methylpiperidin-4-yl) piperazine dihydrochloride . To a stirring suspension of 5% Pd/C (0.6 g) in ethanol (25 mL) under nitrogen was added a solution of 1- (Cbz-D- phenylglycinyl) -4- (l-methylpiperidin-4-yl)piperazine (2.6 g, 5.77 mmol) and acetic acid (1.6 mL) in ethanol (50 mL) . The flask was placed under vacuum and the atmosphere was replaced with hydrogen (balloon) . After 4 h, diatomaceous earth was added and the mixture was filtered through a pad of diatomaceous earth and concentrated in vacuo. The residue was dissolved in ethyl acetate and HCl gas was bubbled through the stirring solution to precipitate the dihydrochloride salt. The mixture was filtered and the solid was dried in vacuo to give 2.6 g (quantitative) of the title compound. IH-NMR IS-MS, m/e 317.3 (M+l) General Procedure: The product of Examples 317-320 was prepared from 1- (D-phenylglycinyl) -4- (l-methylpiperidin-4- yl) piperazine dihydrochloride and the indicated acid using Coupling Method B. Example 317 . 1- (4-Methoxybenzoyl-D-phenylglycinyl) -4- (1-methylpiperidin- 4-yl) piperazine Prepared from 4 -methoxybenzoic acid (19%) . IH-NMR IS-MS, m/e 451.0 (M+l) Analytical RPHPLC, Method 1, RT = 16.76 min (100%) Example 318. 1- (Indole-6-carbonyl-D-phenylglycinyl) -4- (1-methylpiperidin- 4-yl) piperazine Prepared from indole-6 -carboxylic acid (65%) . IH-NMR IS-MS, m/e 460.2 (M+l) Analytical RPHPLC, Method 1, RT = 16.68 min (100%) Example 319. 1- (3-Methylindole-6-carbonyl-D-phenylglycinyl) -4- (l-methylpiperidin-4-yl) piperazine Prepared from 3 -methylindole- 6 -carboxylic acid (50%) . IH-NMR IS-MS, m/e 474.3 (M+l) Analytical RPHPLC, Method 1, RT = 22.20 min (98%) Example 320. 1- (3-Chloroindole-6-carbonyl-D-phenylglycinyl) -4- (1-methylpiperidin-4-yl) piperazine Prepared from 3 -chloroindole-6 -carboxylic acid (76%) . IH-NMR IS-MS, m/e 493.9 (M+l) Analytical RPHPLC, Method 1, RT = 22.66 min (100%) Examples 321 to 324 Preparation of Starting Materials Ethyl hydroxyimino-pyridine-2 -acetate To a stirring solution of ethyl pyridine-2 -acetate (12.6 g, 76.3 mmol) in acetic acid (19 mL) at 5 °C was added a solution of sodium nitrite (6.05 g, 87.7 mmol) in water (12 mL) at a rate sufficient to maintain the internal temperature below 15 °C. After complete addition and an additional 30 min, an additional 30 mL of water was added. The resulting white precipitate was filtered, washed with water, saturated aqueous NaHCθ3 , and again with water. The solid was then dried under vacuum to give 14.1 g (95%) of the title compound. IH-NMR IS-MS, m/e 194.9 (M+l) Analysis for C9H10 2O3: Calcd: C, 55.67; H, 5.19; N, 14.43; Found: C, 55.79; H, 5.14; N, 14.13. Boc-D, L- (2 -Pyridinyl) glycine ethyl ester To a solution of ethyl hydroxyimino-pyridine-2 -acetate (7.8 g, 40.15 g) in ethanol (175 mL) and glacial acetic acid (20 mL) was added 5% Pd/C, and the mixture was shaken in a hydrogenation apparatus under an atmosphere of hydrogen at 3.1 bar for 4 h. The mixture was filtered through diatomaceous earth and concentrated in vacuo. The residue was dissolved in THF/H2O (1:1, 240 mL) and treated with di- tert-butyl dicarbonate (14.23 g, 65.2 mmol) and sodium bicarbonate (27.4 g, 326 mmol). After stirring at room temperature for 2 h, the solution was concentrated in vacuo and the residue was partitioned between EtOAc and water. The organic phase was washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo. The crude material was purified via chromatography over silica gel, eluting with a stepwise gradient of 10-20% ethyl acetate in dichloromethane, to give 8.11 g (72%) of a yellow oil. IH-NMR IS-MS, m/e 281.1 (M+l) 1- [Boc-D, L- (2-Pyridinyl) glycinyl] -1' -methyl-4,4' - bispiperidine To a stirring solution of Boc-D, L- (2 -pyridinyl) glycine ethyl ester (3.89 g, 13.88 mmol) in 1, 4-dioxane (20 mL) was added a solution of lithium hydroxide hydrate (0.64 g, 15.27 mmol) in water (20 mL) . After stirring for 2 h, the solution was concentrated in vacuo. The residue was dried under vacuum for 15 h then dissolved in DMF (50 mL) . The solution was cooled to 0 °C, purged with nitrogen, and diethyl cyanophosphonate (2.5 g, 16.66 mmol) was slowly added. After 2 min, the solution was treated with a solution of l-methyl-4 , 4 ' -bispiperidine dihydrochloride (3.9 g, 15.27 mmol) and triethylamine (6.8 mL, 48.58 mmol) in DMF (50 mL) . After 2 h, the cold bath was removed and the solution was allowed to stir overnight. The next morning, the solvent was evaporated in vacuo and the resulting oil was partitioned between 3:1 chloroform: isopropyl alcohol and saturated aqueous sodium bicarbonate. The organic phase was dried over magnesium sulfate, filtered and concentrated in vacuo. The crude material was purified via chromatography over silica gel, eluting with a stepwise gradient of 5-9% (2 N ammonia in methanol) in dichloromethane to give 2.6 g (45%) of a clear oil. IH-NMR IS-MS, m/e 417.2 (M+l) 1- [D,L- (2 -Pyridinyl) glycinyl] -1' -methyl-4,4' -bispiperidine (Deprotection Method E) To a stirring solution of 1- [Boc- D, L- (2 -pyridinyl) glycinyl] -1' -methyl-4, 4' -bispiperidine (1.8 g, 4.32 mmol) in dichloromethane (90 mL) was added anisole (2.3 mL, 21.6 mmol), followed by trifluoroacetic acid ( 8.3 mL, 108 mmol) . After 4 h, the solvents were evaporated in vacuo, the crude product was dissolved in methanol and loaded onto an SCX column (pretreated with a 5% glacial acetic acid in methanol solution) , rinsed with methanol (2 column volumes) and eluted with a 30% 2 N ammonia/methanol in dichloromethane solution. The product containing fractions were combined and concentrated in vacuo to give 1.08 g (77%) of a yellow oil. IH-NMR IS-MS, m/e 317.2 (M+l) Analysis for C^^s^O- 0.55H 2 0 : Calcd: C, 66.25; H, 8.99; N, 17.17; Found: C, 66.07; H, 8.49; N, 16.66. General Procedure: The product of Examples 321-324 was prepared from 1- [D, L- (2-pyridinyl) glycinyl] -1' -methyl- , 4 ' - bispiperidine and the indicated acid using the procedure described for Example 321 (Coupling Method D) . Example 321. 1- [Indole- 6-carbonyl-D,L- (2-pyridinyl) glycinyl] -l'-methyl- 4,4' -bispiperidine (Coupling Method D) To a stirring solution of l-[D,L-(2- pyridinyl) glycinyl] -1' -methyl-4 , 4' -bispiperidine (0.3 g, 0.95 mmol) in N, N-dimethylformamide (3 mL) was added indole-6-carboxylic acid (0.15 g, 0.95 mmol) and 1-hydroxybenzotriazole hydrate (0.13 g, 0.95 mmol), followed by 1, 3-dicyclohexylcarbodiimide (0.19 g, 0.95 mmol). After stirring overnight, the mixture was filtered and the filtrate was loaded onto an SCX column (pretreated with a 5% glacial acetic acid in methanol solution) , rinsed with methanol (2 column volumes) and eluted with a 30% (2 N ammonia in methanol) in dichloromethane solution. The product containing fractions were concentrated in vacuo and the residue was was chromatographed over silica gel, eluting with a stepwise gradient of 5-9% (2 N ammonia in methanol) in dichloromethane to give 255 mg (58%) of a tan foam. IH-NMR IS-MS, m/e 460.3 (M+l) Analytical RPHPLC, Method 1, RT = 14.90 min (100%) Example 322. 1- [4-Methoxybenzoyl-D,L- (2-pyridinyl) glycinyl] -1' -methyl- 4,4' -bispiperidine Prepared from 4 -methoxybenzoic acid (53%) . IH-NMR IS-MS, m/e 451.2 (M+l) Analytical RPHPLC, Method 1, RT = 14.79 min (98%) Example 323. 1- [3-Methylindol-6-carbonyl-D,L- (2-pyridinyl) glycinyl] -1'- methyl-4,4' -bispiperidine Prepared from 3-methyl-6-carboxyindole (40%) . IH-NMR IS-MS, m/e 474.3 (M+l) Analytical RPHPLC, Method 1, RT = 18.28 min (97%) Example 324 . 1- [3-Chloroindole-6-carbonyl-D,L- (2-pyridinyl) glycinyl] -1'- methyl-4,4' -bispiperidine Prepared from 3-chloro-6-carboxyindole (71%) . IH-NMR IS-MS, m/e 494.0 (M+l) Analysis for C27H32N5O2CI • 0.2H2O : Calcd: C, 65.17; H, 6.56; N, 14.07; Found: C, 65.57; H, 6.56; N, 13.23. Analytical RPHPLC, Method 1, RT = 20.96 min (99%) Examples 325 to 328 Preparation of Starting Materials Ethyl hydroxyimino-pyridine-3 -acetate Using the procedure of Tikk et al . [Acta. Chimica Hungarica, 114(3-4), 355], a mixture of ethyl hydroxyimino-pyridine-3- acetate and n-butyl hydroxyimino-pyridine-3 -acetate was prepared from ethyl pyridine-3 -acetate and n-butyl nitrite. IH-NMR IS-MS, m/e 195 (M+l), 223.1 (M+l) Boc-D, L- (3 -Pyridinyl) glycine ethyl ester Using methods substantially equivalent to those described above in preparation of Boc-D, L- (2-pyridinyl) glycine ethyl ester, the title compound was prepared from the above ethyl hydroxyimino-pyridine-3 -acetate (57%) . IH-NMR IS-MS, m/e 281.KM+1) 1- [Boc-D, L- (3 -Pyridinyl) glycinyl] -1' -methyl-4,4' - bispiperidine Using methods substantially equivalent to those described in preparation of 1- [Boc-D, L- (2-pyridinyl) glycinyl] -1' -methyl- 4 , 4 ' -bispiperidine, the title compound was prepared from Boc-D, L- (3-pyridinyl) glycine ethyl ester (20%). IH-NMR IS-MS, m/e 417.2 (M+l) 1- [D,L- (3 -Pyridinyl) glycinyl] -1' -methyl-4,4' -bispiperidine Using methods substantially equivalent to those described in preparation of 1- [D, L- (2-pyridinyl) glycinyl] -1' -methyl-4, 4' - bispiperidine, the title compound was prepared from 1- [Boc-D, L- (3-pyridinyl) glycinyl] -1' -methyl-4,4' - bispiperidine (75%) . IH-NMR IS-MS, m/e 317.2 (M+l) General Procedure: The product of Examples 325-328 was prepared from 1- [D, L- (3-pyridinyl) glycinyl] -1' -methyl-4 , 4' - bispiperidine and the indicated acid using the procedure described for Example 325 (Coupling Method D) . Example 325. 1- [4-Methoxybenzoyl-D,L- (3 -pyridinyl) glycinyl] -1' -methyl- 4,4' -bispiperidine Prepared from 4 -methoxybenzoic acid (45%) . IH-NMR IS-MS, m/e 451.2 (M+l) Analysis for C26 H 34 N 4θ3 ' 1 • 2H 2 0: Calcd: C, 66.13; H, 7.77; N, 11.87; Found: C, 66.61; H, 7.27; N, 11.87. Analytical RPHPLC, Method 1, RT = 12.98 min (98%) Example 326. 1- [Indole-6-carbonyl-D,L- (3-pyridinyl) glycinyl] -1' -methyl- 4,4' -bispiperidine Prepared from indole-6-carboxylic acid (36%) . IH-NMR IS-MS, m/e 460.3 (M+l) Analysis for C27H33N5O2 • 1.5H 2 0: Calcd: C, 66.64; H, 7.46; N, 14.39; Found: C, 66.71; H, 6.87; N, 13.89. Analytical RPHPLC, Method 1, RT = 14.39 min (100%) Example 327. 1- [3-Methylindole-6-carbonyl-D,L- (3-pyridinyl) glycinyl] -1'- methyl-4, 4' -bispiperidine Prepared from 3 -methylindole-6-carboxylic acid (40%) . IH-NMR IS-MS, m/e 474.3 (M+l) Analysis for C28H35N5O2 • 1.6H 2 0: Calcd: C, 66.93; H, 7.66; N, 13.94; Found: C, 66.63; H, 6.99; N, 13.52. Analytical RPHPLC, Method 1, RT = 16.98 min (98%) Example 328. 1- [3-Chloroindole-6 -carbonyl-D,L- (3-pyridinyl) glycinyl] -1' - methyl-4,4' -bispiperidine Prepared from 3-chloroindole-6-carboxylic acid (46%) . IH-NMR IS-MS, m/e 494.2 (M+l) Analysis for C27H32CIN5O2 ■ 1.1H 2 0 : Calcd: C, 63.11; H, 6.71; N, 13.63; Found: C, 62.84; H, 6.32; N, 13.26. Analytical RPHPLC, Method 1, RT = 19.63 min (100%) Examples 329 to 330 Preparation of Starting Materials Boc-D- [3- (ethanesulfonylamino) phenyl] glycine To a stirring solution of D-3— (ethanesulfonylamino) - phenylglycine (20 g, 77.43 mmol) and sodium carbonate (8.2 g, 77.43 mmol) in 3:1 THF/water (200 mL) at 0 °C, was added di-tert-butyl dicarbonate (18.5 g, 85.17 mmol). After stirring for 30 min, the cold bath was removed; and after an additional 30 min at room temperature, the solvent was removed and the residue was partitioned between ethyl acetate and water. The aqueous layer was acidified to pH 2 with KHSO4 and extracted twice with ethyl acetate. The combined ethyl acetate extracts were washed with water, dried with Na2Sθ4, filtered and concentrated in vacuo to give 17.51 g (63%) of a white solid. IH-NMR IS-MS, m/e 357.0 (M-l) 1- [Boc-D- [3- (ethanesulfonylamino) phenyl] glycinyl] -1' -methyl- 4,4' -bispiperidine To a stirring solution of Boc-D- [3- (ethanesulfonylamino) - phenyl] glycine (5 g, 13.95 mmol) in dichloromethane at 0 °C, diethyl cyanophosphonate (2.12 mL, 13.95 mmol) and diisopropylethylamine (4.86 mL, 27.91 mmol) and then N-methylbispiperidine dihydrobromide (4.32 g, 12.56 mmol) were added; and the mixture was stirred at 0 °C for 3 h. The reaction mixture was then stirred at room temperature overnight, filtered, washed with saturated aqueous sodium bicarbonate and water, dried over sodium sulfate, filtered and concentrated in vacuo to give 5 g (76%) of a tan foam. IH-NMR IS-MS, m/e (M+l) 1- [D- [3- (Ethanesulfonylamino) phenyl] glycinyl] -1' -methyl- 4,4' -bispiperidine Using Deprotection Method E, the title compound was prepared from 1- [Boc-D- [3- (ethanesulfonylamino) phenyl] glycinyl] -1' - methyl-4 ,4' -bispiperidine (74%). IH-NMR IS-MS, m/e 423.1 (M+l) Analysis for C21H34N4O3S • 1.3H 2 0 : Calcd: C, 56.55; H, 8.27; N, 12.56; Found: C, 56.68; H, 7.87; N, 11.97. General Procedure: The product of Examples 329-330 was prepared from 1- [D- [3- (ethanesulfonylamino) phenyl] glycinyl] - 1' -methyl-4 , 4' -bispiperidine and the indicated acid using the procedure described for Example 321 (Coupling Method D) . Example 329. 1- [4 -Methoxybenzoyl-D- [3- (ethanesulfonylamino) - phenyl] glycinyl] -1' -methyl-4,4' -bispiperidine Prepared from 4-methoxybenzoic acid (43%) . IH-NMR IS-MS, m/e 557.3 (M+l) Analysis for C29H40N4O5S .0.9H 2 0: Calcd: C, 60.79; H, 7.35; N, 9.78; Found: C, 60.49; H, 7.08; N, 9.62. Analytical RPHPLC, Method 1, RT = 22.68 min (98%) Example 330 . 1- [Indole-6-carbonyl-D- [3- (ethanesulfonylamino) - phenyl] glycinyl] -1' -methyl-4,4' -bispiperidine Prepared from indole-6-carboxylic acid (58%) . IH-NMR IS-MS, m/e (M+l) Analysis for C30H39N5O4S .2H 0: Calcd: C, 59.88; H, 7.20; N, 11.64; Found: C, 59.97; H, 6.65; N, 11.43. Analytical RPHPLC, Method 1, RT = 29.02 min (98%) Example 331. 1- (3-Aminoindazole-5-carbonyl-D-phenylglycinyl) -1' -methyl- 4,4' -bispiperidine To a stirring solution of 1- (3-cyano-4-fluorobenzoyl-D- phenylglycinyl) -1' -methyl-4 , 4' -bispiperidine (120 mg, 0.259 mmol) in p-dioxane (6 mL) was added hydrazine hydrate (26 mg, 0.518 mmol), and the solution was heated to reflux. After 2 h, the heat was removed and the solvent was evaporated in vacuo. The residue was dissolved in ethanol and heated to reflux. After 12 h, the solution was cooled and concentrated in vacuo. The residue was chromatographed over silica gel, eluting with 10% (2 N ammonia in mthanol) in dichloromethane. The product containing fractions were combined and concentrated in vacuo to give 75 mg (62%) of an off white solid. IH-NMR IS-MS, m/e 475.3 (M+l) Analytical RPHPLC, Method 1, RT = 14.72 min (100%) Example 332 . 1- (l-Methyl-3-aminoindazole-5-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine Using methods substantially equivalent to those described in Example 331, the title compound was prepared from methylhydrazine and 1- (3 -cyano-4-fluorobenzoyl-D- phenylglycinyl) -1' -methyl-4, 4' -bispiperidine (31%) . IH-NMR IS-MS, m/e 489.2 (M+l) Analytical RPHPLC [Vydac C18, linear gradient of 98/2 - 80/20 (0.1% TFA in water / 0.1% TFA in acetonitrile) over 40 min, 1 mL/min] RT = 38.99 min (100%). Example 333. 1- (Imidazo [1, 2-a] pyrimidine-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine Imidazo [1, 2-a] pyrimidine-2 -carboxylic acid To a stirring solution of ethyl 1- (imidazo [1, 2-a] pyrimidine- 2 -carboxylate (1 g, 5.2 mmol) [Abignente, et al . Eur. J. Med. Chem. (1994) 23. ι 279] in ethanol (30 mL) was added 2 N aqueous KOH (10 mL, 20 mmol) . The solution was heated to reflux; and after 2 h, the heating mantle was removed, the solution was allowed to cool and the solvent was removed by rotary evaporation. The residue was dissolved in water (20 mL) and acidified to pH 3 with 5 N HCl. The resulting precipitate was filtered, washed with water and dried in vacuo to give 700 mg (83%) of a tan solid. IH-NMR FD-MS, m/e 163.2 (M+l) Analysis for C 7 H5N3O2: Calcd: C, 51.54; H, 3.09; N, 25.76; Found : C , 51 . 12 ; H , 3 . 25 ; N , 25 . 25 . 1- (Imidazo [1, 2-a] pyrimidine-2-carbonyl-D-phenylglycinyl) -1' - methyl-4,4' -bispiperidine Using Coupling Method B, the title compound was prepared from imidazo [1, 2-a] pyrimidine-2 -carboxylic acid and 1-D- phenylglycinyl-l' -methyl-4 , 4 ' -bispiperidine (56%) . IH-NMR IS-MS, m/e 461.2 (M+l) Analytical RPHPLC [Vydac C18, linear gradient of 98/2 - 80/20 (0.1% TFA in water / 0.1% TFA in acetonitrile) over 40 min, 1 mL/min] RT = 32.72 min (96%). Example 334. 1- (5,6,7, 8-Tetrahydro-imidazo [1,2 -a] pyrimidine-2 -carbonyl-D- phenylglycinyl) -1' -methyl-4,4' -bispiperidine To a stirring solution of 1- (imidazo [1, 2-a] yrimidine-2 - carbonyl-D-phenylglycinyl) -1' -methyl-4 , 4 ' -bispiperidine (250 mg, 0.542 mmol) in ethanol (5 mL) was added sodium borohydride (103 mg, 2.71 mmol). After 24 h, the mixture was diluted with water and extracted 3 times with dichloromethane. The organic phase was dried (MgSU4) , filtered and concentrated in vacuo. The residue was dissolved in dichloromethane and chromatographed over silica gel, eluting with 5% through 10% (2 N NH 3 in MeOH) in dichloromethane. The product containing fractions were combined and concentrated in vacuo to give 55 mg (20%) of the title compound. IH-NMR IS-MS, m/e 465.2 (M+l) Analytical RPHPLC [Vydac C18, linear gradient of 98/2 - 80/20 (0.1% TFA in water / 0.1% TFA in acetonitrile) over 40 min, 1 mL/min] RT = 28.44 min (97%). Examples 335 to 338 Preparation of Starting Materials Ethyl hydroxyimino-pyridine-4-acetate The oxime was prepared in 82% yield from ethyl pyridine-4- acetate using a procedure similar to that described above under Examples 321-324 for the preparation of ethyl hydroxyimino-pyridine-2 -acetate. IH-NMR (DMSO) IS-MS, m/e 194.9 (M+l) Boc-D, L- (4 -Pyridinyl) glycine ethyl ester The protected amino ester is prepared from ethyl hydroxyimino-pyridine-4 -acetate using a procedure similar to that described above under Examples 321-324 for the preparation of Boc-D, L- (2-pyridinyl) glycine ethyl ester. 1- [Boc-D, L- (4 -Pyridinyl) glycinyl] -1' -methyl-4,4' - bispiperidine The protected amide is prepared from Boc-D, L- (4-pyridinyl) - glycine ethyl ester and 1-methyl-4, 4 ' -bispiperidine dihydrochloride using a procedure similar to that described above under Examples 321-324 for the preparation of 1- [Boc- D, L- (2-pyridinyl) glycinyl] -1' -methyl-4 , 4' -bispiperidine. 1- [D,L- (4-Pyridinyl) glycinyl] -1' -methyl-4,4' -bispiperidine The amine is prepared from 1- [Boc-D, L- (4-pyridinyl) - glycinyl] -1' -methyl-4 , 4' -bispiperidine using a procedure similar to that described above under Examples 321-324 for the preparation of 1- [D, L- (2-pyridinyl) glycinyl] -1' -methyl- 4,4 ' -bispiperidine . General Procedure: The product of Examples 335-338 is prepared from 1- [D, L- (4-pyridinyl) glycinyl] -1' -methyl- , 4' - bispiperidine and the indicated acid using Coupling Method D. Example 335. 1- [4-Methoxybenzoyl-D,L- (4-pyridinyl) glycinyl] -1' -methyl- 4,4 ' -bispiperidine From 4-methoxybenzoic acid. Example 336. 1- (Indole-6-carbonyl-D,L- (4-pyridinyl) glycinyl] -1' -methyl- 4,4' -bispiperidine From indole-6-carboxylic acid. Example 337. 1- [3-Methylindole-6-carbonyl-D,L- (4-pyridinyl) glycinyl] -1' - methyl-4, 4' -bispiperidine From 3-methylindole-6-carboxylic acid. Example 338. 1- [3-Chloroindole-6-carbonyl-D,L- (4-pyridinyl) glycinyl] -1' - methyl-4,4' -bispiperidine From 3-chloroindole-6-carboxylic acid. Assay protocols Enzyme Inhibition assays: The ability of a test compound to inhibit factor Xa may be evaluated in one or more of the following Enzyme Inhibition assays, or in other standard assays known to those skilled in the art . Enzyme Inhibition Assay 1 Enzyme assays were carried out at room temperature in 0.1M phosphate buffer, pH7.4 according to the method of Tapparelli et al (J. Biol. Chem. 1993,268,4734-4741). Purified human factor Xa, trypsin, thrombin and plasmin were purchased from Alexis Corporation, Nottingham, UK. Urokinase was purchased from Calbiochem, Nottingham, UK. Chromogenic substrates for these enzymes; pefachrome-FXA, pefachrome- TRY, pefachrome-TH, pefachrome-PL and pefachrome-UK were purchased from Pentapharm AG, Basel, Switzerland. Product (p-nitroaniline) was quantified by adsorption at 405nm in 96 well microplates using a Dynatech MR5000 reader (Dynex Ltd, Billingshurst, UK) . Km and Ki were calculated using SAS PROC NLIN (SAS Institute, Cary, NC, USA, Release 6.11) K m values were determined as 100.9μM for factor Xa/pefachrome-FXA and 81.6μM for trypsin/pefachrome-TRY. Inhibitor stock solutions were prepared at 40mM in Me2SO and tested at 500μM, 50μM and 5μM. Accuracy of Ki measurements was confirmed by comparison with Ki values of known inhibitors of factor Xa and trypsin. In agreement with published data, benzamidine inhibited factor Xa, trypsin, thrombin, plasmin and urokinase with Ki values of 155μM, 21μM, 330nM, 200nM and lOOnM respectively. NAPAP inhibited thrombin with a Ki value of 3nM. Compounds of the invention were found to have activity in these assays . Enzyme Inhibition Assay 2 Human factor Xa and human thrombin were purchased from Enzyme Research Laboratories (South Bend, Indiana, USA) . Other proteases were from other commercial sources. Chromogenic para-nitroanilide peptide protease substrates were purchased from Midwest Biotech (Fishers, Indiana, USA) The binding affinities for human factor Xa were measured as apparent association constants (Kass) derived from protease inhibition kinetics as described previously. a /b, c /d The apparent Kass values were obtained using automated (BioMek- 1000) dilutions of inhibitors (Kass determinations are performed in triplicate at each of four-eight inhibitor concentrations) into 96-well plates and chromogenic substrate hydrolysis rates determined at 405 nm using a Thermomax plate reader from Molecular Devices (San Francisco) . For factor Xa inhibition, the assay protocol was: 50 μl buffer (0.06 M tris, 0.3 M NaCl, pH 7.4); 25 μl inhibitor test solution (in MeOH) ; 25 μl human factor Xa (32 nM in 0.03 M tris, 0.15 M NaCl, 1 mg/ml HSA); finally, 150 μl BzIleGluGlyArgpNA (0.3 mM in water) added within 2 min to start hydrolysis. Final factor Xa was 3.2 nM. Free [Xa] and bound [Xa] were determined from linear standard curves on the same plate by use of SoftmaxPro software for each inhibitor concentration and apparent Kass calculated for each inhibitor concentration which produced hydrolysis inhibition between 20% and 80% of the control (3.2 nM factor Xa) : apparent Kass = [E: I] / [E f ] [l f ] = [E b ] / [E f ] [I°-I b ] . The apparent Kass values so obtained are approximately the inverse of the Ki for the respective inhibitors [1/appKass = app Ki] . The variability of mean apparent Kass values determined at the single substrate concentration was +/- 15%. The assay system Km was measured as 0.347 +/- 0.031 mM [n=4] ; and Vmax was 13.11 +/- 0.76 μM/min. Kass values were determined with thrombin and other proteases using the same protocol with the following enzyme and substrate concentrations: thrombin 5.9 nM with 0.2 mM BzPheValArgpNA; XIa 1.2 nM with 0.4 mM pyroGluProArgpNA; Xlla 10 nM with 0.2 mM HDProPheArgpNA; plasmin 3.4 nM with 0.5 mM HDValLeuLyspNA; nt-PA 1.2 nM with 0.8 mM HDIleProArgpNA; and urokinase 0.4 nM with 0.4 mM pyroGluGlyArgpNA; aPC 3 nM with 0.174 mM pyroGluProArgpNA; plasma kallikrein 1.9 nM with D-ProPheArgpNA; bovine trypsin 1.4 nM with 0.18 mM BzPheValArgpNA. Citations (a) Sail DJ, JA Bastian, SL Briggs, JA Buben, NY Chirgadze, DK Clawson, ML Denny, DD Giera, DS Gifford- Moore, R Harper, KL Hauser, VJ Klimkowski, TJ Kohn, H- S Lin, JR McCowan, AD Palkowitz, GF Smith, ME Richett, K Takeuchi, KJ Thrasher, JM Tinsley, BG Utterback, S-CB Yan, M Zhang. Dibasic Benzo [b] hiophenes Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure-Activity Relationships and Binding Orientation. J Med Chem 40.3489-3493 (1997) . (b) Smith GF, TJ Craft, DS Gifford-Moore, J Coffman, KD Kurz, E Roberts, RT Shuman, GE Sandusky, ND Jones, N Chirgadze, and CV Jackson. A Family of Arginal Thrombin Inhibitors Related to Efegatran. Sem. Thrombos . Hemost. 22., 173-183 (1996) . (c) Smith GF, DS Gifford-Moore, TJ Craft, N Chirgadze, KJ Ruterbories, TD Lindstrom, JH Satterwhite. Efegatran: A New Cardiovascular Anticoagulant. In New Anticoagulants for the Cardiovascular Patient. Ed. R Pifarre. Hanley & Belfus, Inc., Philadelphia (1997) pp 265-300. (d) Sail DJ, JA Bastian, NY Chirgadze, ML Denny, MJ Fisher, DS Gifford-Moore, R Harper, VJ Klimkowski, TJ Kohn, HS Lin, JR McCowan, ME Richett, GF Smith, K Takeuchi, JE Toth, M Zhang. Diamino Benzo [b] thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors: 5. Potency, Efficacy and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives. In press, J Med Chem (1999). In general, the compounds of formula (I) exemplified in Part 1 of the Examples herein have been found to exhibit a Ki of 10 μM or less in Assay 1 and/or a Kass of at least 0.1 x 10 6 L/mole in Assay 2. The ability of a test compound to elongate Partial Thromboplastin Time (Prothrombin Time) may be evaluated in the following test protocols. Partial Thromboplastin Time (Prothrombin) Test Protocol Venous blood was collected into 3.2% (0.109m) trisodium citrate vacutainer tubes at 1 volume of anticoagulant to nine volumes of blood. The blood cells were separated by centrifugation at 700g for ten minutes to yield plasma, which was frozen at 70°C until required. To perform the test, lOOμl of plasma was pipetted into in a glass test tube, lμl of test compound in DMSO was added, and allowed to warm to 37° over two minutes. lOOμl of warm (37°) Manchester (tissue thromboplasin) reagent (Helena Biosciences, UK) was added, allowed to equilibrate for two minutes. lOOμl of warm (37°) 25mM calcium chloride solution was added to initiate clotting. The test tube was tilted three times through a 90° angle every five seconds to mix the reagents and the time to clot formation recorded. Data from a series of observations and test compound concentrations are analysed by a SAS statistical analysis program and a CT2 (Concentration required to double clotting time) for each compound is generated. Compounds of the invention were found to significantly elongate the partial thromboplastin time (Prothrombin time) . a The concentration quoted is that of the solution which, when added to the other reagents in the assay, doubles prothrombin time. The final concentration in the assay mixture is one third of this value. By way of comparison with the result for the compound of Example 66, the compound of Example 75 of 099/11657 was found to double prothrombin time at a concentration of 11.4μM (average of 3 tests) . By way of comparison with the result for the compound of Example 35, l-aminoisoquinolin-7-oyl-D-phenylglycine-4- (4-fluoro-2-methanesulfonylphenyl) -piperazinamide ditrifluoroactetate salt (a compound within the scope of W099/11657) was found to double prothrombin time at a concentration of 45μM (average of 3 tests) . Alternative Prothrombin Time and APTT Protocols Coagulation Determinations. Prothrombin Times and APTT values were determined in HUMAN PLASMA with a STA instrument (Stago) . BioPT is a special non-plasma clotting assay triggered with human tissue factor (Innovin) . Possible binding to albumen or to lipid was assessed by comparing the BioPT effects in the presence/absence of 30 mg/ml human albumen (HSA) and 1 mg/ml phosphatidyl choline (PC) . Inhibitors were delivered in 50% MeOH vehicle. APTT ASSAY 75 μl plasma Citrol Baxter-Dade Citrated Normal Human Plasma 25 μl test sol ' n 75 μl Actin Baxter-Dade Activated Cephaloplastin incubate 2 min min. @ 37° 75 μl CaCl 2 (0.02 M) PT ASSAY 75 μl plasma 25 μl test sol ' n 75 μl saline incubate 1 min. @ 37° C 75 μl Innovin Baxter-Dade Recombinant Human Tissue Factor Compounds of the invention were found to be potent inhibitors of factor Xa. Examples - Part 2 Experimental : Abbreviations used follow IUPAC-IUB nomenclature. Additional abbreviations are HPLC, high-performance liquid chromatography; LC/MS, liquid chromatography / mass spectrometry; rt, retention time; NMR, nuclear magnetic resonance, TBTU, 2- (IH- (benzotriazol-1-yl) -1, 1, 3 , 3- tetramethyluroniumtetrafluoroborate. Starting materials were purchased from Aldrich (Gillingham, UK) , Lancaster (Morecambe, UK) , Avocado (Heysham, UK) , Maybridge (Tintagel, UK) , Nova Biochem (Nottingham, UK) or Bachem. Purification: Flash column chromatography was carried out using Merck silica gel Si60 (40-63 μm, 230-400 mesh) . Purification of final products was by crystallisation, flash column chromatography or gradient reverse phase HPLC on a Waters Deltaprep 4000 at a flow rate of 50 mL/minute using a Deltapak C18 radial compression column (40 mm x 210 mm, 10- 15 mm particle size) . Eluant A consisted of aqueous trifluoroacetic acid (0.1 %) and eluant B 90% acetonitrile in aqueous trifluoroacetic acid (0.1 %) with gradient elution (Gradient, 0 minutes 5 % B for 1 minutes, then 5 % B to 20 % B over 4 minutes, then 20 % B to 60 % B over 32 minutes) . Fractions were analysed by analytical HPLC and LC/MS before pooling those with >95 % purity for lyophilisation . Analysis: Proton nuclear magnetic resonance ( X H NMR) spectra were recorded on a Bruker DPX300 (300 MHz) . Analytical HPLC ' s were performed on a Shimadzu LC6 gradient system equipped with an autosampler. Eluant A consisted of aqueous trifluoroacetic acid (0.1 %) and eluant B consisted of 90 % acetonitrile and 10 % water, containing trifluoroacetic acid (0.1 %) . Gradient 1 elution began at 5 % B and increased to 100 % B over seven minutes. Gradient 2 elution began at 5 % B and increased to 100 % B over ten minutes. Gradient 3 elution began at 5 % B for one minute, increasing to 20 % B after the fourth minute, 40 % B after the 14 th minute and then 100 % B after the 15 th minute. The columns used were Luna 2 C18 (3 μ, 30 mm x 4.6 mm), Luna 2 C18 (5 μ, 150 mm x 2 mm) and a Symmetry Rp8 (3.5 μ, 50 x 2.1 mm) . LC/MS were performed on a PESCIEX single quadrupole API- 150EX instrument, equipped with a Luna 2 C18 column (3 μ, 30 mm x 4.6 mm) eluting with 20 % to 100 % acetonitrile in water over five minutes . Example 1 3- (Aminomethyl)benzoyl-D-phenylglycine 2- aminobenzothiazol-6-amide bis (trifluoroacetate) salt 2, 6-Diaminobenzothiazole 2-Amino-6-nitrobenzothiazole (500 mg, 2.56 mmol) was dissolved in methanol (20 mL) and 10 % palladium on carbon (50 mg) was added as a slurry in methanol (1 mL) . The atmosphere was replaced with hydrogen and the suspension was stirred overnight. The catalyst was removed by suction filtration and the solvent evaporated to afford 2,6- diaminobenzothiazole (420 mg, 99 %) as a pale yellow solid. N-BOC-D-Phenylglycine 2-aminobenzothiazol-6-amide N-BOC-D-Phenylglycine (250 mg, 1.0 mmol), l-(3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (190 mg, 1.0 mmol) and 7-aza-l-hydroxybenzotriazole (140 mg, 1.0 mmol) were stirred in dimethylformamide (3 mL) for ten minutes. 2, 6-Diaminobenzothiazole (160 mg, 1.0 mmol) was then added and the solution was stirred overnight at room temperature. Ethyl acetate (15 mL) was added and the solution was washed with water (5 mL) , saturated citric acid solution (5 mL) , saturated ΝaHC0 3 (5 mL) and water (5 mL) , and dried over MgS0 4 . The solvent was removed under reduced pressure to afford N-BOC-D-phenylglycine 2- aminobenzothiazol-6-amide . H NMR (CDC1 3 ) : 8.93 (1 H, br s, C(O)NHAr); 7.72 (1 H, s, benzothiazole C(7)H); 7.35 (2 H, br s, Ph) ; 7.23 - 7.05 (3 H, m, Ph) ; 6.93 (1 H, d, J " = 10 Hz, benzothiazole C(4)H or C(5)H); 6.72 (1 H, d, J = 10 Hz, benzothiazole C(4)H or C(5)H); 6.05 (1 H, d, J = 7 Hz, CHPh) ; 5.92 (2 H, br s, NH 2 ) ; 5 . 45 ( 1 H , br S , BOCNH) ; 1 . 27 ( 9 H , S , fc Bu) . D-Phenylglycine 2-aminobenzothiazol-6-amide A solution of N-BOC-D-phenylglycine 2-aminobenzothiazol-5- amide in dichloromethane (5 mL) was treated with trifluoroacetic acid (5 mL) and stirred for 30 minutes. The dichloromethane and excess trifluoroacetic acid were removed under reduced pressure and the residue was triturated with diethyl ether to afford D-phenylglycine 2-aminobenzothiazol- 6-amide as its trifluoroacetate salt (350 mg, 89 %) . 3- (Aminomethyl) benzoyl-D-phenylglycine 2-aminobenzothiazol- 6-amide trifluoroacetate salt N-BOC- 3 -aminomethylbenzoic acid (250 mg, 1.0 mmol), 1- (3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (190 mg, 1.0 mmol) and 7-aza-l-hydroxybenzotriazole (140 mg, 1.0 mmol) were stirred in dimethylformamide (10 mL) for five minutes. D-Phenylglycine 2-aminobenzothiazol-6-amide trifluoroacetate salt (350 mg, 0.85 mmol) was then added and the mixture was stirred overnight. The solution was poured into ethyl acetate (20 mL) and washed with 5 % HCl (5 mL) , saturated NaHC0 3 (5 mL) and water (5 mL) , dried over MgS0 4 and the solvent removed under reduced pressure. The crude product was purified by flash column chromatography on silica gel (60 % ethyl acetate / 40 % hexane to 100 % ethyl acetate) to afford N-BOC-3 - (aminomethyl) benzoyl-D- phenylglycine 2-aminobenzothiazol-6-amide . This was dissolved in dichloromethane (5 mL) and trifluoroacetic acid (5 mL) was added. The solution was stirred at room temperature for 30 minutes before the dichloromethane and excess trifluoroacetic acid were removed under reduced pressure. The residue was triturated with diethyl ether to afford 3- (aminomethyl )benzoyl -D-phenylglycine 2- aminobenzothiazol-6-amide as its trifluoroacetate salt (150 mg, 32 %) . X H NMR (d 4 MeOH): 8.21 ppm (1 H, s, benzothiazole C(7)H); 7.97 (1 H, s, aminomethylbenzoyl C(2)H); 7.94 (1 H, d, J = 5 Hz, 3- (aminomethyl ) benzoyl C(6)H); 7.80 - 7.48 (5 H, m, Ar) ; 7.47 - 7.32 (4 H, m, Ar) ; 5.81 (1 H, s, CHPh); 4.22 (2 H, s, CH 2 NH 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.80 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.40 minutes, 432 (MH) + . Examples 2 - 34 were prepared in the same fashion as Example 1, starting with the indicated nitro-compound or amine. Other functional groups present were protected appropriately . Example 2 3- (Aminomethyl) benzoyl-D-phenylglycine phenyl mide trifluoroacetate salt Prepared from aniline. X H NMR (d 4 MeOH): 7.85 ppm (2 H, br s, Ar) ; 7.49 (6 H, m, Ar) ; 7.27 (5 H, m, Ar) 7.01 (1 H, t, J " = 9 Hz, Ar) ; 5.70 (1 H, s, CHPh); 4.12 (2 H, s, CH 2 NH 2 ) . HPLC (Luna 2, Gradient 1): rt = 3.59 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.99 minutes, 360 (MH) + . Example 3 2-Amino-5- (aminomethyl) benzoyl-D-phenylglycine (1S, 2S, 3S, 5R) -iso inocamphamide dihydrochloride salt Prepared from ( IS, 2S, 3S, 5R) - ( + ) -isopinocampheylamine . X H NMR (d4 MeOH): 7.52 ppm (1 H, s, Ar-C(6)H); 7.42 (2 H, d, J " = 10, 2 x Ph-o-CH) ; 7.32 - 7.2 (3 H, m, 2 x Ph-m-CH, Ph-p- CH) ; 7.12 (1 H, d, J " = 11 Hz, Ar-C(4)H) ; 6.67 (1 H, d, J = 11 Hz, Ar-C(3)H) ; 5.53 (1 H, S, NCH(Ph)) ; 4.18 (1 H, quintet, J = 8 Hz, ipc-C(l)H) ; 3.90 (2 H, s, CH 2 NH 2 ) ; 2.42 - 2.23 (2 H, m, ipc-C(3)H and ipc- (C (2)H) ; 1.91 (1 H, m, ipc- (C)6H) ; 1.80 (1 H, br s, ipc- (C) 5H) ; 1.74 (1 H, t, J = 5 Hz, ipc-(C)6H) ; 1.32 (1 H, dd, J = 14, 8 Hz, ipc-C(7)H) ; 1.14 (3 H, s, ipc-C(8)H 3 ) ; 1.02 (3 H, d, J = 8 Hz, ipc-C (10) H 3 ) ; 0.95 (3 H, s, ipc-C(9)H 3 ); 0.87 (1 H, d, J = 11 Hz, ipc-C(7)H). HPLC (Luna 2, Gradient 1): rt = 4.21 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.10 minutes, 418 (MH-NH 3 ) + . Example 4 3- (Aminomethyl) benzoyl-D-phenylglycine quinolin-3- ylamide trifluoroacetate salt Prepared from 3-aminoquinoline . X H NMR (d 4 MeOH) : 9.21 and 8.88 ppm (1 H each, s, quinoline C(2)H and C(4)H) ; 8.10 - 7.90 (4 H, m, Ar) ; 7.81 (IH, t, J " = 7 Hz, Ar) ; 7.77 - 7.55 (5 H, m, Ar) ; 7.53 - 7.25 (3 H, m, Ar) ; 5.91 (1 H, s, CHPh); 4.20 (2 H, s, CH 2 NH 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.98 minutes. LC/MS (Luna 2, Gradient 4) : rt = 1.83 minutes, 411 (MH) + . Example 5 3- (Aminomethyl) benzoyl-D-phenylglycine 4- (1- piperidyDphenylamide trifluoroacetate salt Prepared from 4- (1-piperidyl) aniline . *H NMR (d 4 MeOH): 7.97 ppm (2 H, m, Ar) ; 7.8 (2 H, d, J " = 9 Hz, Ar) ; 7.7 - 7.35 (9 H, m, Ar) ; 5.8 (1 H, s, CHPh); 4.2 (2 H, s, CH 2 NH 2 ) ; 3.55 (4 H, m, pip); 2.0 (4 H, m, pip); 1.8 (2 H, m. pip) . HPLC (Luna 2, Gradient 1): rt = 2.81 minutes LC/MS (Luna 2, Gradient 4) : rt = 0.59 minutes, 443 (MH) + Example 6: 3- (Aminomethyl)benzoyl-D-phenylglycine 1- oxoindan-5-amide trifluoroacetate salt Prepared from 5-amino-l-oxoindane . X H NMR (d 4 MeOH): 7.98 ppm (1 H, s, (aminomethyl) benzoyl C(2)H); 7.96 ppm (1 H, d, J = 10 Hz, (aminomethyl) benzoyl C(6)H); 7.94 (1 H, s, indanone C(4)H); 7.70 - 7.52 (6 H, m, Ar) ; 7.47 - 7.33 (3 H, m, Ar) ; 5.84 (1 H, s, CHPh); 4.22 (2 H, s, CH 2 NH 2 ) ; 3.12 (2 H, t, J = 5 Hz, indanone C(3)H 2 ); 2.82 - 2.75 (2 H, m, indanone C(2)H 2 ). HPLC (Luna 2, Gradient 1): rt = 3.35 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.78 minutes, 414 (MH) + . Example 7 3- (Aminomethyl) benzoyl-D-phenylglycine 3-cyano-4- methylphenyl-amide trifluoroacetate salt Prepared from 3-cyano-4-methylaniline. X H NMR (d 4 MeOH): 8.01 ppm (1 H, s, 3 -cyano-4 -methylphenyl C(2)H); 7.98 (1, s, 3 - (aminomethyl) benzoyl C(2)H); 7.94 (1 H, d, J = 9 Hz, 3- (aminomethyl) enzoyl C(6)H); 7.72 - 7.52 (5 H, m, Ar) ; 7.48 - 7.28 (4 H, m, Ar) ; 5.82 (1 H, s, CHPh); 4.19 (2 H, s, CH 2 NH 2 ) ; 2.47 (3 H, s, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.72 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.05 minutes, 399 (MH) + . Example 8 3- (Aminomethyl)benzoyl-D-phenylglycine 4-amido phenylamide trifluoroacetate salt Prepared from 4-nitrobenzamide . *H NMR (d 4 MeOH): 8.20 - 8.05 ppm (2 H, m, 3- (aminomethyl) benzoyl C(2)H and C(6)H); 7.97 (2 H, d, J = 9 Hz, 4- (amidocarbonyl) henyl C(2)H and C(6)H); 7.86 (2 H, d, -7 = 9 Hz, 4- (amidocarbonyl) phenyl C(3)H and C(5)H); 7.82 - 7.65 (4 H, m, Ar) ; 7.63 - 7.47 (3 H, m, Ar) ; 6.01, (1 H, s, CHPh); 4.32 (2 H, br s, CH 2 NH 2 ) . HPLC (Symmetry C8 , Gradient 2): rt = 4.84 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.51 minutes, 403 (MH) + . Example 9 3- (Aminomethyl) benzoyl-D-phenylglycine 3- amidophenylamide trifluoroacetate salt Prepared from 3-nitrobenzamide . X H NMR (d 4 MeOH): 8.30 ppm (1, s, 3- (amidocarbonyl) phenyl C(2)H); 8.17 (1 H, s, 3 - (aminomethyl) benzoyl C(2)H); 8.12 (1 H, d, J = 8 Hz, 3- (aminomethyl) benzoyl C(6)H); 7.93 (1 H, d, J " = 7 Hz, 3- (amidocarbonyl) phenyl C(6)H); 7.85 - 7.68 (5 H, m, Ar) ; 7.65 - 7.52 (4 H, m, Ar) ; 6.03 (1 H, s, CHPh); 4.37 (2 H, br s, CH 2 NH 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.95 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.78 minutes, 403 (MH) + . Example 10 3- (Aminomethyl) benzoyl-D-phenylglycine 1,2,3,4- tetrahydro-l-oxonaphthyl-6-amide trifluoroacetate salt. Prepared from 6-amino-l, 2, 3 , 4-tetrahydro-l-oxonaphthalene . *H NMR (d 4 MeOH): 7.72 ppm (3 H, m, Ar) ; 7.40 (6 H, m, Ar) ; 7.20 (3 H, m, Ar) ; 5.65 (1 H, s, CHPh); 4.02 (2 H, S, CH 2 NH 2 ) ; 2.78 (2 H, t, J = 6 Hz, tetrahydronaphthyl C(4)H 2 ); 2.42 (2 H, t, J = 1 Hz, tetrahydronaphthyl C(2)H 2 ); 1.95 (2H, m, tetrahydronaphthyl C(3)H 2 ). HPLC (Luna 2, gradient 1): rt = 3.57 minutes. LC/MS (Luna 2, gradient 4): rt = 1.88 minutes; 428 (MH) + . Example 11 3- (Aminomethyl) benzoyl-D-phenylglycine 1,2,3,4- tetrahydro-l-oxonaphthyl-7-amide trifluoroacetate salt Prepared from 7-nitro-l, 2 , 3 , 4-tetrahydro-l-oxonaphthalene . X H NMR (d 4 MeOH): 8.04 ppm (1 H, s, tetrahydronaphthyl C(8)H); 7.82 (2 H, dd, J = 1, 10 Hz, Ar) ; 7.60 (2 H, dd, Ar) ; 7.45 (4 H, m, Ar) ; 7.28 (3 H, m, Ar) ; 7.16 (1 H, m, Ar) ; 5.68 (1 H, br s , CHPh); 4.03 (2 H, s, CH 2 NH 2 ) , 2.83 (2 H, t, J = 1 Hz, tetrahydronaphthyl C(4)H 2 ); 2.40 (2 H, t, J " = 7 Hz, tetrahydronaphthyl C(2)H 2 ); 2.00 (2 H, m, tetrahydronaphthyl C(3)H 2 ). HPLC (Luna 2, gradient 1) : rt = 3.65 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.94 minutes, 428 (MH) + . Example 12 3- (Aminomethyl) benzoyl-D-phenylglycine 1,2,3,4- tetrahydro-naphthyl-6-amide trifluoroacetate salt Prepared from 6-amino-l, 2 , 3 , 4-tetrahydronaphthalene . *H NMR (d 4 MeOH): 7.72 ppm (1 H, s, 3- (aminomethyl) benzoyl C(2)H); 7.70 (1 H, d, J = 7 Hz, 3- (aminomethyl) benzoyl C(6)H); 7.40 (4 H, m, Ar) ; 7.22 (3 H, m, Ar) ; 7.09 (1 H, m, Ar) ; 6.82 (1 H, m, Ar) ; 5.62 (1 H, s, CHPh); 4.00 (2 H, s, CH 2 NH 2 ) ; 2.50 (4 H, s,); 1.58 (4 H, s, tetrahydronaphthyl C(4)H 2 and C(5)H 2 ) . HPLC (Luna 2, Gradient 4): rt = 4.21 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.21 minutes, 414 (MH) + . Example 13 3- (Aminomethyl) benzoyl-D-phenylglycine 4- (piperazin-1- yl) phenyl-amide bis (trifluoroacetate) salt Prepared from 4- (piperazin-1-yl) aniline . X H NMR (d 4 MeOH): 8.00 ppm (2 H, m, Ar) ; 7.70 - 7.35 (9 H, m, Ar) ; 7 . 02 ( 2 H , d , J " = 10 Hz , Ar) ; 5 . 80 ( 1 H , s , CHPh) ; 4 . 21 ( 2 H , s , CH 2 NH 2 ) ; 3 . 30 ( 8 H , m, pip) . HPLC (Luna 2, Gradient 1): rt = 2.71 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.59 minutes, 444 (MH) + . Example 14 3- (Aminomethyl) benzoyl-D-phenylglycine 2, 3-dihydroindol 5-amide bis (trifluoroacetate) salt Prepared from 2 , 3-dihydro-5-nitroindole . 'H NMR (d 4 MeOH): 7.97 ppm (2 H, m, Ar) ; 7.82 (1 H, s, Ar) ; 7.65 (5 H, m, Ar) ; 7.45 (4 H, m, Ar) ; 5.80 (1 H, s, CHPh); 4.20 (2 H, s, CH 2 NH 2 ) ; 3.85 (2 H, t, J " = 7.5 Hz, dihydroindole C(2)H 2 ); 3.30 (2 H, t, J = 7.5 Hz, dihydroindole C(3)H 2 ). HPLC (Luna 2, Gradient 1): rt = 2.59 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.59 minutes, 401 (MH) + . Example 15 3- (Aminomethyl) benzoyl-D-phenylglycine 4-chloro-3- amidophenylamide trifluoroacetate salt Prepared from 2-chloro-5-nitrobenzamide . *H NMR (d 4 MeOH): 7.98 ppm (1, s, 3 - (aminomethyl) benzoyl C(2)H); 7.94 (1 H, d, J " = 9 Hz, 3 - (aminomethyl) benzoyl C(6)H); 7.83 (1 H, s, 2 -chloro-3- (amidocarbonyl) -phenyl C(6)H); 7.70 - 7.50 (5 H, m, Ar) ; 7.45 - 7.35 (4 H, m, Ar) ; 5.58 (1 H, s, CHPh); 4.21 (2 H, s, CH 2 NH 2 ) . HPLC (Luna 2, Gradient 1): rt = 3.09 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.62 minutes, 437/439 (MH) + . Example 16 3- (Aminomethyl) benzoyl-D-phenylglycine 3,5- dichlorophenylamide trifluoroacetate salt Prepared from 3 , 5-dichloroaniline . X H NMR (d 4 MeOH): 7.98 ppm (1, s, 3- (aminomethyl) benzoyl C(2)H); 7.94 (1 H, d, J = 9 Hz, 3 - (aminomethyl) benzoyl C(6)H); 7.73 - 7.51 (4 H, m, Ar) ; 7.64 (2 H, s, 3,5- dichlorophenyl C(2)H and C(6)H); 7.49 - 7.32 (3 H, m, Ar) ; 7.18 (1 H, s, 3,5-dichlorophenyl C(4)H); 5.80 (1 H, s, CHPh); 4.20 (2 H, s, CH 2 NH 2 ) . HPLC (Luna 2, Gradient 1): rt = 4.31 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.29 minutes, 428/430/432 (MH) + . Example 17 3- (Aminomethyl) benzoyl-D-phenylglycine 3- (aminomethyl) phenyl-amide bis (trifluoroacetate) salt Prepared from 3-nitrobenzylamine . 'H NMR (d 4 MeOH) : 7.97 ppm (2 H, m Ar) ; 7.82 (1 H, s, Ar) ; 7.61 (5 H, m, Ar) ; 7.40 (4 H, m, Ar) ; 7.22 (1 H, d, J " = 11 Hz, Ar) ; 5.81 (1 H, s, CHPh) ; 4.22 (2 H, s, CH 2 NH 2 ) ; 4.10 (2 H, s, CH 2 NH 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.67 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.59 minutes, 389 (MH) + . Example 18 3- (Aminomethyl) benzoyl-D-phenylglycine 2,3- dimethylindol-5-amide bis (trifluoroacetate) salt Prepared from 2, 3 -dimethyl-5 -nitroindole. X H NMR (d 3 acetonitrile): 9.12 ppm (1 H, br s, NH) ; 9.08 (IH, bs, NH) ; 8.40 (1 H, d, J = 1 Hz, Ar) , 8.20 (1 H, s, Ar) ; 8.0 (1 H, d, -7 = 7 Hz, Ar) ; 7.88-7.50 (7 H, m, Ar) ; 7.30 (2 H, m, Ar) ; 6.0 (1 H, d, J = 6.5 Hz, CHPh); 4.30 (2 H, s, CH 2 NH 2 ) ; 2.71 (2 H, br s, CH 2 NH 2 ) ; 2.50 (3 H, s, indole C ( 3 ) CH 3 ) ; 2 . 31 ( 3 H , s , indole C ( 2 ) CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.76 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.99 minutes, 427 (MH) + . Example 19 3- (Aminomethyl) benzoyl-D-phenylglycine 4- chlorophenylamide trifluoroacetate salt Prepared from 4-chloroaniline . *H NMR (d 4 MeOH): 7.97 ppm (2 H, m, Ar) ; 7.70 - 7.50 (13 H, m, Ar) ; 5.80 (1 H, S, CHPh); 4.21 (2 H, S, CH 2 NH 2 ) . HPLC (Luna 2, Gradient 1): rt = 3.95 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.05 minutes, 394 (MH) + . Example 20 1- [3- (Aminomethyl) benzoyl-D-phenylglycinyl] piperidine trifluoroacetate salt Prepared from piperidine. X H NMR (d 4 MeOH): 7.97 ppm (2 H, m Ar) ; 7.65 - 7.30 (7 H, m, Ar) ; 6.10 (1 H, s, CHPh); 4.21 (2H, s, CH 2 NH 2 ) ; 3.79 (IH, m, pip); 3.50 (3H, m, pip); 1.70 - 1.21 (5 H, m, pip). HPLC (Luna 2, Gradient 1): rt = 3.36 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.78 minutes, 394 (MH) + . Example 21 1- [3- (Aminomethyl) benzoyl-D-phenylglycinyl] -3- [ (N-ethyl- JV-methyl) amido] piperidine trifluoroacetate salt Prepared from 3- [ (N-ethyl -N-methyl ) amidocarbonyl] - piperidine. X H ΝMR (CD 3 CΝ) : The compound contains two chiral centres and is therefore a mixture of diastereomers, as well as exhibiting rotamers due to the N-ethyl -N-methyl amide. 8.45 - 7.78 ppm (5 H, m, Ar and ΝH) ; 7.72 - 7.28 (5 H, m, Ph) ; 6.10 - 5.90 (1 H, m, CHPh); 4.61 - 4.35 (1 H, m, piperidine H) ; 4.14 (2 H, br s, CH 2 NH 2 ) ; 3.97 - 3.66 (1 H, m, piperidine H) ; 3.50 - 2.35 (12 H, m) 1.90 - 0.75 (4 H, m) . HPLC (Luna 2, Gradient 1): rt = 3.13 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.72 minutes, 437 (MH) + . Example 22 1- [3- (Aminomethyl)benzoyl-D-phenylglycinyl] pyrrolidine trifluoroacetate salt Prepared from pyrrolidine. X H NMR (d 4 MeOH): 7.95 ppm (2 H, m, Ar) ; 7.72-7.34 (7 H, m, Ar) ; 5.91 (1 H, m, CHPh); 4.20 (2 H, S, CH 2 NH 2 ) ; 3.80 (2 H, m, pyr); 3.61 (2 H, m, pyr); 3.50 (2 H, m, pyr); 3.19 (2 H, m, pyr) . HPLC (Luna 2, Gradient 1): rt = 3.06 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.57 minutes, 338 (MH) + . Example 23 2- [3- (Aminomethyl) benzoyl-D-phenylglycinyl] decahydroisoquinoline trifluoroacetate salt Prepared from decahydroisoquinoline. *H NMR (d 4 MeOH): 7.70 ppm (2 H, br s, Ar) ; 7.41 -7.09 (7 H, m, Ar) ; 5.95-5.78 (IH, m, CHPh); 3.95 (2H, s, CH 2 NH 2 ) ; 1.7 - 0.65 (16 H, m, decahydroisoquinoline C(H)'s). HPLC (Luna 2, Gradient 1): rt = 4.11 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.15 minutes, 406 (MH) + . Example 24 3- (Aminomethyl) benzoyl-D-phenylglycine 2, 3 -dihydroindol- 6-amide trifluoroacetate salt Prepared from 2 , 3-dihydro-6-nitroindole . *H NMR (d 4 MeOH): 7.91 ppm (2 H, m, Ar) ; 7.75 (1 H, s, Ar) ; 7.57 (4 H, m, Ar) ; 7.34 (5 H, m, Ar) ; 5.75 (1 H, s, CHPh) ; 4.15 (2 H, s, CH 2 NH 2 ) ; 3.75 (2 H, t, J = 7.5 Hz, dihydroindole C(2)H 2 ); 3.20 (2 H, t, J = 7.5 Hz, dihydroindole C(3)H 2 ). HPLC (Luna 2, Gradient 1): rt = 2.54 minutes. LC/MS (Luna 2, Gradient 4) : rt = 1.24 minutes, 401 (MH) + . Example 25 3- (Aminomethyl) benzoyl-D-phenylglycine 2,3- dihydroindolamide trifluoroacetate salt Prepared from 2, 3 -dihydroindole . X H NMR (d 4 MeOH) : 8.92 ppm (1 H, d, -7 = 7 Hz, NH) ; 8.22 (1 H, d, -J = 9.5 Hz, dihydroindole C(7)H); 7.97 (2 H, m, Ar) ; 7.48 (3 H, m, Ar) ; 7.19 (2 H, m, Ar) ; 7.08 (1 H, m, Ar) ; 6.02 (1 H, m, CHPh); 4.41 (1 H, m, dihydroindole C(2)H); 4.19 (2H, s, CH 2 NH 2 ) ; 3.78 (IH, m, dihydroindole C(2)H); 3.23 (IH, m, dihydroindole C(3)H); 3.07 (IH, m, dihydroindole C(3)H) . HPLC (Luna 2, Gradient 1): rt = 3.79 minutes. LC/MS (Luna 2, gradient 4): rt = 2.21minutes, 386 (MH) + . Example 26 3- (Aminomethyl)benzoyl-D-phenylglycine l-methyl-2 , 3- dihydro-indol-6-amide bis (trifluoracetate salt) Prepared from 6-amino-2, 3-dihydro-l-methylindole. 'H NMR (d 4 MeOH): 8.0 ppm (2 H, m, Ar) ; 7.65 (4 H, m, Ar) ; 7.40 (3 H, m, Ar) ; 7.15 (2 H, m, Ar) ; 6.95 (1 H, m, Ar) ; 5.83 (1 H, s, CHPh); 4.20 (2 H, s, CH 2 NH 2 ) ; 3.42 (2 H, m, dihydroindole C(2)H); 2.98 (2H, m, dihydroindole C(3)H); 2.82 (3H, s, NCH 3 ) . HPLC (Luna 2, Gradient 1): rt = 2.80 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.88 minutes, 415 (MH) + . Example 27 3- (Aminomethyl) benzoyl-D-phenylglycine 3-acetylamino-4- methylphenylamide trifluoroacetate salt Prepared from 2-methyl-5-nitroacetanilide . X H NMR (D 2 0) : 7.78 - 7.19 (12 H, m, Ar) , 5.64 (IH, s, α-CH) , 4.17 (2 H, s, CH 2 NH 2 ) , 2.12 (6H, s, 2 x CH 3 ) HPLC (Luna 2, Gradient 1): rt = 3.10 minutes. LC/MS (Luna 2, Gradient 4):rt = 1.56 minutes, 431 (MH + ) . Example 28 3- (Aminomethyl) benzoyl-D-phenylglycine (R/S) -8-methyl- 5, 6,7, 8-tetrahydronaphth-2-ylamide trifluoroacetate salt Prepared from (R/S) -8-methyl-5, 6, 7, 8-tetrahydronaphth-2- ylamine, synthesised as described below. (R/S) -8-methyl-5, 6,7, 8-tetrahydronaphth-2-ylamine A suspension of methyltriphenylphosphonium iodide (680 mg, 1.68 mmol) in tetrahydrofuran (7 mL) was cooled to -45°C. n- Butyllithium (1.0 mL, 1.6 M in hexane, 1.60 mmol) was then added dropwise, and the solution was stirred for 1 hour. 1, 2, 3, 4 -Tetrahydro-7-nitro- 1-oxonaphthalene (200 mg, 1.05 mmol) in tetrahydrofuran (3 mL) was then added over 5 minutes. The reaction mixture was allowed to warm to room temperature before being quenched with water (20 mL) . The solution was then extracted with dichloromethane (2 x 25 mL) , the solvent was dried (MgS0 4 ) and concentrated under reduced pressure to give a black oil. The crude product was then purified by flash chromatography (ethyl acetate / hexane; 1:40) to afford 5, 6, 7, 8 -tetrahydro- 8 -methylene-2- nitro-naphthalene as a white solid (150 mg, 76%) . A solution of the olefin (100 mg, 0.53 mmol) in methanol (2 mL) was stirred over 10% palladium on carbon (20 mg) . The mixture was purged with hydrogen and stirred for 18 hrs under a balloon of hydrogen. The reaction mixture was then filtered through celite, washing with additional methanol, and concentrated under reduced pressure to afford (R/S) -8- methyl-5, 6, 7, 8-tetrahydronaphth-2-ylamine as a colourless oil (75 mg, 82%) . X H NMR (CDC1 3 ) : 7.53 ppm (1 H, d, J " = 8 Hz, C(4)H) ; 7.21 (1 H, d, J " = 2 Hz, C(l)H) ; 7.18 (1 H, dd, J " = 8 , 2 Hz, C(3)H) ; 4.16 (2 H, br s, NH 2 ) ; 3.52 (1 H, sextet, J " = 7 Hz, CHCH 3 ) ; 3.41-3.25 (2 H, m, C(5)H 2 ); 2.61-2.45 (2 H, m, tetrahydronaphthalene C(6)H and/or C(7)H); 2.43-2.32 (1 H, m, tetrahydronaphthalene C(6) or C(7)H); 2.23-2.12 (1 H, m, tetrahydronaphthalene C(6)H or C(7)H); 1.96 (3 H, d, J = 1 Hz, CH 3 ) . 3- (Aminomethyl) benzoyl-D-phenylglycine (R/S) -8-methyl- 5, 6, 7, 8-tetrahydro-naphth-2-ylamide trifluoroacetate salt. X H NMR (MeOH): 7.95 ppm (2 H, br s, Ar) ; 7.76 - 7.60 (4 H, m, Ar) ; 7.48 - 7.31 (4 H, m, Ar) ; 7.29 - 7.21 (1 H, m, Ar) ; 6.97 (1 H, d, J = 8 Hz, Ar) ; 5.80 (1 H, S, CHPh); 4.18 (2 H, s, CH 2 NH 2 ) ; 2.90 - 2.69 (3 H, m, tetrahydronaphthalene C(5)H and C(8)H 2 ); 1.99-1.80 (2 H, m, tetrahydronaphthalene C(6)H and/or C(7)H); 1.75 - 1.63 (1 H, m, tetrahydronaphthalene C(6) or C(7)H); 1.58 - 1.40 (1 H, m, tetrahydro-naphthalene C(6)H or C(7)H) ; 1.27 (3 H, d, J = 1 Hz, CH 3 ) . HPLC (Symmetry, Gradient 2): rt = 6.73 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.53 minutes, 428 (MH) + . Example 29 3- (Aminomethyl) benzoyl-D-phenylglycine indan-5-ylamide trifluoroacetate salt Prepared from 5-aminoindane. X B. NMR (d 4 MeOH): 8.16 ppm (1 H, s, 3- (aminomethyl) benzoyl C(2)H); 8.15 (1 H, m, 3 - (aminomethyl) benzoyl C(6)H); 7.96 - 7.54 (8 H, m, Ar) ; 7.45 (1 H, d, J = 8 Hz, indane C(6)H or C(7)H); 7.33 (1 H, d, J = 8 Hz, indane C(6)H or C(7)H); 6.0 (1 H, s, CHPh); 4.39 (2 H, s, CH 2 NH 2 ) ; 3.06 (4 H, q, J " = 7 Hz, indane C(1)H 2 and C(3)H 2 ); 2.26 (2 H, quintet, J = 1 Hz, indane C(2)H 2 ) . HPLC (Luna 2, Gradient 1): rt = 4.02 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.42 minutes, 400 (MH) + . Example 30 3- (Aminomethyl) benzoyl-D-phenylglycine 4- isopropylphenylamide trifluoroacetate salt Prepared from 4-isopropylaniline . X H NMR (d 4 MeOH): 8.17 ppm (1 H, s, 3- (aminomethyl) benzoyl C(2)H); 8.15 (1 H, m, 3- (aminomethyl) benzoyl C(6)H); 7.83 - 7.59 (9 H, m, Ar) ; 7.38 (2 H, d, J " = 8.5 Hz, Ar) ; 6.0 (1 H, s, CHPh); 4.38 (2 H, s, CH 2 NH 2 ) ; 3.09 (1 H, septet, J " = 7 Hz, CH(CH 3 ) 2 ); 1.42 (6 H, d, -7 = 7 Hz, CH(CH 3 ) 2 ). HPLC (Luna 2, Gradient 1): rt = 4.21 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.48 minutes, 402 (MH) + . Example 31 3- (Aminomethyl) benzoyl-D-phenylglycine (1S, 2S, 3S, 5R) - isopinocamphamide trifluoroacetate salt Prepared from ( IS, 2S, 3S, 5R) - (+) -isopinocampheylamine . *H NMR (d 4 MeOH): 7.96 ppm (1 H, s, 3- (aminomethyl) benzoyl C(2)H); 7.95 (1 H, m, 3 - (aminomethyl) benzoyl C(6)H); 7.67 - 7.25 (7 H, m, Ar) ; 5.70 (1 H, s, CHPh); 4.28 (1 H, m, isopinocampheyl C(l)H); 4.20 (2 H, s, CH 2 NH 2 ) ; 2.55 - 1.77 (5 H, m, isopinocampheyl H's); 1.26 (3 H, s, CH 3 ) ; 1.14 (3 H, d, J = 7Hz, isopinocampheyl C(10)H 3 ); 1.08 (3 H, s, CH 3 ) ; 1.04 - 0.94 (2 H, m, isopinocampheyl H's). HPLC (Luna 2, Gradient 1): rt = 4.34 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.34 minutes, 420 (MH) + . Example 32 3- (Aminomethyl) benzoyl-D-phenylglycine 4- (1- hydroxyethyl) phenylamide trifluoroacetate salt Prepared from 1- (4 -aminophenyl) ethanol . X H NMR (d 4 MeOH): 7.85 ppm (1 H, s, 3- (aminomethyl) benzoyl C(2)H); 7.84 (1 H, m, 3 - (aminomethyl) benzoyl C(6)H); 7.56 - 7.05 (11 H, m, Ar) ; 5.72 (1 H, s, CHPh); 4.69 (1 H, q, J = 6.5 Hz, CH(OH)CH 3 ); 4.08 (2 H, s, CH 2 NH 2 ) ; 1.31 (3 H, d, J = 6.5 Hz, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.0 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.83 minutes, 404 (MH) + . Example 33 3- (Aminomethyl)benzoyl-D-phenylglycine cis-2- aminocyclohexyl-amide bis (trifluoroacetate) salt Prepared from cis-1, 2-diaminocyclohexane. X H NMR (d 4 MeOH): 8.08 ppm (1 H, s, 3- (aminomethyl) benzoyl C(2)H); 8.06 (1 H, m, 3 - (aminomethyl) benzoyl C(6)H); 7.79 - 7.48 (7 H, m, Ar) ; 5.87 (1 H, s, CHPh); 4.46 (1 H, m, cyclohexyl C(l)H); 4.30 (2 H, s, CH 2 NH 2 ) ; 3.54 (1 H, m, cyclohexyl C(2)H); 2.11 - 1.52 (8 H, m, cyclohexyl H's). HPLC (Luna 2, Gradient 1); rt = 2.40 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.08 minutes, 381 (MH) + . Example 34 1- [3- (Aminomethyl)benzoyl-D-phenylglycinyl] 4- hydroxypiperidine hydrochloride salt Prepared from 4-hydroxypiperidine. *H NMR (d 4 MeOH): 7.84 ppm (1 H, s, 3- (aminomethyl) benzoyl C(2)H); 7.80 (1 H, m, 3- (aminomethyl) benzoyl C(6)H); 7.59 - 7.17 (7 H, m, Ar) ; 6.03 (1 H, s, CHPh); 4.11 (2 H, s, CH 2 NH 2 ) ; 3.90 (1 H, -m, piperidyl C(4)H); 3.62 (2 H, m, piperidyl C(2)H and C(6)H); 3.14 - 2.94 (2 H, m, piperidyl C(2)H and C(6)H); 1.93 - 1.16 (4 H, m, piperidyl C(3)H 2 and C(5)H 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.56 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.36 minutes, 368 (MH) + . Example 35 3- (Aminomethyl) benzoyl-D-phenylglycine l-acetyl-2, 3 - dihydro-indol-6 -amide trifluoroacetate salt 1-Benzyloxycarbonyl-2,3-dihydro-6-nitroindole A solution of 6-nitroindoline (10.0 g, 0.061 mol), triethylamine (22.7 mL, 0.16 mol) and dimethylaminopyridine (50 mg, cat.) in dichloromethane (130 mL) was stirred at 0°C and benzyl chloroformate (18 mL, 0.12 mol) was added slowly. The mixture was allowed to warm to room temperature overnight. The mixture was washed with water (50 mL) , 5% aqueous HCl (100 mL) , saturated aqueous NaHC0 3 (50 mL) and water (50 mL) . The dichloromethane was dried (MgS0 4 ) and evaporated under reduced pressure to give an orange solid. This was triturated in diethyl ether (150 ml) to give a yellow solid (12.34 g, 68%). X H NMR (CDC1 3 ) : 7.80 ppm (1 H, dd, J = 8, 2 Hz, C(7)H); 7.35 (5 H, m, Ph) ; 7.20 (2 H, m, C(4)H and C(5)H); 5.25 (2 H, br s, CH 2 Ph) ; 4.11 (2 H, t, J " = 8 Hz, dihydroindole C(2)H 2 ); 3.15 (2 H, t, J = 8 Hz, dihydroindole C(3)H 2 ). 6-amino-l-benzyloxycarbonyl-2, 3 -dihydroindole A mixture of 1-benzyloxycarbonyl-2, 3-dihydro-6-nitroindole (1.0 g, 3.36 mmol) and tin (II) chloride dihydrate (3.78 g, 16.75 mmol) in ethanol (70 mL) was heated at 70°C, under an atmosphere of nitrogen, for 3 hours. The solution was cooled and the solvent evaporated under reduced pressure to give an off-white solid. The solid was partitioned between water (50 mL) and ethyl actate (100 mL) and the aqueous layer basified (pH 11) with 1M sodium hydroxide solution. The mixture was filtered to remove tin salts and the ethyl acetate was separated, dried (MgS0 4 ) and evaporated under reduced pressure to give the amine as a yellow oil (0.89 g, 99 %) X H NMR (CDC1 3 ) : 7.51 - 7.33 ppm (6 H, m, Ph + C(7)H); 6.93 (1 H, d, J = 8 Hz, C(4)H) ; 6.32 (1 H, dd, J = 8, 2 Hz, C(5)H) ; 5.28 (2 H, br s, CH-Ph) ; 4.01 (2 H, t, J " = 7.5 Hz, dihydroindole C(2)H 2 ); 3.66 (2 H, bs, NH 2 ) ; 3.05 (2 H, t, J = 7.5 Hz, dihydroindole C(3)H 2 ). N-BOC-D-phenylglycine l-benzyloxycarbonyl-2, 3 -dihydroindol- 6-amide A solution of N-BOC-D-phenylglycine (0.83 g, 3.28 mmol), 1- [3- (dimethyl -amino) propyl] -3-ethylcarbodiimide hydrochloride (0.75 g, 3.9 mmol), l-hydroxy-7-azabenzotriazole (0.54 g, 3.9 mmol) and 4- (N, N-dimethylamino) pyridine (10 mg, cat.) in dimethylformamide (20 mL) was stirred at room temperature and a solution of the above amine (0.88 g, 3.28 mmol) in dimethylformamide (20 mL) was added and the mixture allowed to stir overnight. The dimethylformamide was evaporated under reduced pressure and the resulting oil partitioned between water (50 mL) and ethyl acetate (50 mL) . The ethyl acetate was washed with 5% aqueous HCl (10 mL) and saturated aqueous ΝaHC0 3 (10 mL) , dried (MgS0 4 ) and evaporated under reduced pressure to give the amide as a golden foam (1.6 g, 97 %) . X H NMR (CDC1 3 ) : 7.43 - 7.10 ppm (13 H, m, Ar) : 6.85 (1 H, d, J = 6 Hz, NH) ; 5.61 (1 H, br s, NH) ; 5.03 (2 H, br s, CH-Ph) ; 3.85 (2 H, t, J = 1 Hz, dihydroindole C(2)H 2 ); 2.85 (2 H, t, J " = 8 Hz, dihydroindole C(3)H 2 ); 1.19 (9 H, s, Bu) . D-phenylglycine l-benzyloxycarbonyl-2, 3 -dihydroindol-6-amide trifluoroacetate salt Trifluoroacetic acid (5 mL) was added to a solution of the above foam in dichloromethane (20 mL) and the solution was allowed to stir for 2 hours at room temperature. The solvent was evaporated under reduced pressure to give the amine trifluoracetate salt as a red foam (1.5 g, 91 %) which was used without further purification. 3- (iV-BOC-Aminomethyl) benzoyl-D-phenylglycine (1- benzyloxycarbonyl-2, 3 -dihydro) -indol-6-amide A solution of 3- (N-BOC-aminomethyl ) benzoic acid (0.798 g, 3.2 mmol), 1- [3- (dimethylamino) propyl] -3-ethylcarbodiimide hydrochloride (0.73 g, 3.8 mmol), l-hydroxy-7- azabenzotriazole (0.52 g, 3.8 mmol) and triethylamine (1.0 mL, 7.2 mmol) in dimethylformamide (10 mL) was stirred at room temperature and a solution of the above amine (1.5 g, 3.0 mmol) in dimethylformamide (5 mL) was added. The mixture was stirred overnight before the dimethylformamide was evaporated under reduced pressure, and the resulting oil partitioned between water (50 mL) and ethyl acetate (50 mL) . The ethyl acetate layer was washed with 5% aqueous HCl (10 mL) and saturated aqueous ΝaHC0 3 (10 mL) , dried (MgS0 4 ) and evaporated under reduced pressure to give a yellow solid. X H NMR (CDCI 3 ) : 7.75 - 7.22 ppm (17 H, m, Ar) : 7.05 (1 H, d, -7 = 5.5 Hz, NH) ; 5.74 (IH, d, J " = 6 Hz, CHPh); 5.21 (2 H, s, OCH 2 Ph) ; 4.89 (1 H, br s, NH) ; 4.32 (2 H, d, J = 6 Hz, CH 2 NHBOC) ; 4.02 (2H, t , J = 8 Hz, dihydroindole C(2)H 2 ); 3.05 (2H, t, J = 8 Hz, dihydroindole C(3)H 2 ); 1.4 (9 H. s, 'Bu) . 3- (iV-BOC-Aminomethyl) benzoyl-D-phenylglycine 2,3- dihydroindol-6 -amide A solution of the above solid in methanol (50 mL) was stirred over 10%Pd/C (500 mg) under an atmosphere of H 2 and heated under reflux for 2 hours. The mixture was cooled, filtered and the solvent evaporated under reduced pressure to provide the unprotected dihydroindole as a yellow foam (1.4g, 88%) which was used without further purification. 3- (Aminomethyl) benzoyl-D-phenylglycine l-acetyl-2, 3- dihydroindol-6-amide trifluoroacetate salt A solution of the dihydroindole (500 mg, 1.0 mmol) and triethylamine (0.28 mL, 2 mmol) in dichloromethane (20 mL) was stirred at 0°C and acetyl chloride (86 mg, 1.1 mmol) was added dropwise, then left to stir overnight. The mixture was washed with 5% aqueous HCl (10 mL) and the organic phase was dried (MgS0 4 ) and evaporated. The residue was purified by flash column chromatography (ethyl acetate / hexane, 1:1) to give a yellow oil. The oil was dissolved in dichloromethane (20 mL) and treated with trifluoroacetic aid (5 mL) . After stirring for 2 hours the solvent was evaporated under redued pressure to an oil, which after triturating with diethyl ether gave the amine as its trifluoroacetate salt as a white solid (337 mg, 61 %) . X H NMR (d 4 MeOH): 8.30 ppm (1 H, s, Ar) ; 7.97 (2 H, m, Ar) ; 7.60 (4 H, m, Ar) ; 7.39 (4 H, 3, m, Ar) ; 7.22 (1 H, d, J = 10 Hz, Ar) ; 5.82 (1 H, s, CHPh); 4.2 (2 H, s, CH 2 NH 2 ) ; 4.15 (2 H, t, -7 = 7 Hz, dihydroindole C(2)H 2 ); 3.17 (2 H, t, J " = 7 Hz, dihydroindole C(3)H 2 ); 2.25 (3 H, s, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.39 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.72 minutes, 443 (MH) + . Examples 36 - 60 were prepared from the intermediate 3 - (N- BOC-aminomethyl) -benzoyl-D-phenylglycine 2 , 3 -dihydroindol -5- amide, described for Example 29, and the appropriate carboxylic acid or derivative, using standard chemical methods and protecting other functionality where required. Example 36 3- (Aminomethyl) benzoyl-D-phenylglycine l-propanoyl-2 , 3- dihydro-indol-6-amide trifluoroacetate salt Prepared using propanoyl chloride. X H ΝMR (d 4 MeOH) : 8.58 ppm (1 H, d, J " = 1.2 Hz, dihydroindole C(7)H); 8.18 (2 H, m, Ar) ; 7.82 (4 H, m, Ar) ; 7.59 (4 H, m, Ar) ; 7.37 (1 H, m, Ar) ; 6.03 (1 H, s, CHPh); 4.39 (2 H, s, CH 2 ΝH 2 ) ; 4.31 (2 H, t, J = 9 Hz, dihydroindole C(2)H); 3.37 (2 H, t, J = 9 Hz, dihydroindole C(3)H); 2.73 (2 H, q, J = 7.5 Hz, CH 2 CH 3 ) ; 1.47 (3 H, t, J = 7.5 Hz, CH 2 CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.55 minutes. LC/MS (Luna 2, Gradient 4):rt = 1.94 minutes, 457 (MH) + . Example 37 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (2-methyl- propanoyl) -2 , 3 -dihydroindol-6-amide trifluoroacetate salt Prepared using 2-methylpropanoyl chloride. X H NMR (d 4 MeOH): 8.32 ppm (1 H, s, dihydroindole C(7)H); 7.98 (2 H, m, Ar) ; 7.60 (4 H, m, Ar) ; 7.43 (4 H, m, Ar) ; 7.18 (1 H, m, Ar) ; 5.83 (1 H, s, CHPh); 4.21 (4 H, m, CH 2 NH 2 and dihydroindole C(2)H); 3.18 (2 H, t, J " = 9 Hz, dihydroindole C(3)H), 2.95 (1 H, m, CH(CH 3 ) 2 ); 1.22 (6 H, d, J " = 8 Hz, CH(CH 3 ) 2 ) . HPLC (Luna 2, Gradient 1): rt = 3.74 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.05 minutes, 471 (MH) + . Example 38 3- (Aminomethyl) benzoyl-D-phenylglycine 1-D-alaninoyl- 2, 3 -dihydroindol-6-amide bis (trifluoroacetate) salt Prepared using D-alanine. X H NMR (d 4 MeOH): 8.40 ppm (1 H, s, Ar) ; 8.01 (2 H, m, Ar) ; 7.65 (4 H, m, Ar) ; 7.45 (4 H, m, Ar) ; 7.25 (1 H, d, J = 10 Hz, Ar) ; 5.85 (1 H, s, CHPh); 4.4 (1 H, q, J " = 7 Hz, alaninyl CHNH 2 ) ; 4.25 (2 H, s, ArCH 2 NH 2 ) ; 4.25 (2 H, t, J " = 8 Hz, dihydroindole C(2)H 2 ); 3.28 (2 H, t, J " = 8 Hz , dihydroindole C(3)H 2 ); 1.65 (3 H, d, J = 7 Hz, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 2.85 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.35 minutes, 472 (MH) + . Example 39 3- (Aminomethyl) benzoyl-D-phenylglycine 1-L-alaninoyl- 2, 3 -dihydroindol-6-amide bis (trifluoroacetate) salt Prepared using L-alanine. X H NMR (d 4 MeOH): 8.43 ppm (1 H, s, Ar) ; 7.97 (2 H, m, Ar) ; 7.63 (4 H, m, Ar) ; 7.45 (4 H, m, Ar) ; 7.25 (1 H, d, J " = 10 Hz, Ar) ; 5.85 (1 H, s, CHPh); 4.35 (1 H, q, J " = 7 Hz, alaninyl CHNH 2 ) ; 4.25 (2H, t, J = 7.5 Hz, indoline C(2)H 2 ); 4.2 (2 H, s, CH 2 NH 2 ) ; 3.25 (2H, t , J " = 8 Hz, indoline C(3)H 2 ) ; 1.6 (3 H, d, J = 1 Hz, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 2.84 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.59 minutes, 472 (MH) + . Example 40 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (N-acetyl-D- alaninoyl) -2, 3 -dihydroindol-6 -amide trifluoroacetate salt Prepared using N-acetyl -D-alanine . 'H ΝMR (d 4 MeOH): 8.33 ppm (1 H, s, Ar) ; 7.97 (2 H, m, Ar) ; 7.61 (4 H, m, Ar) ; 7.40 (4 H, m, Ar) ; 7.18 (1 H, d, J = 9 Hz, Ar) ; 5.83 (1 H, S, CHPh); 4.70 (1 H, br m, CHΝHAc) ; 4.38 (1 H, m, indoline C(2)H); 4.21 (2H, s, CH 2 ΝH 2 ) ; 4.20 (1 H, t, J = 8 Hz indoline C(2)H); 3.2 (2 H, t, J " = 8 Hz, indoline C(3)H 2 ); 2.01 (3 H, s, COCH 3 ) ; 1.4 (3 H, d, J " = 7 Hz, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.24 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.59 minutes, 514 (MH) + . Example 41 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (JV-acetyl-L- alaninoyl) -2 , 3 -dihydroindol-6 -amide trifluoroacetate salt Prepared using N-acetyl -L-alanine . X H ΝMR (d 4 MeOH): 8.33 ppm (1 H, s, Ar) ; 7.97 (2 H, m, Ar) ; 7.62 (4 H, m, Ar) ; 7.38 (4 H, m, Ar) ; 7.18 (1 H, d, Ar) ; 5.83 (1 H, s, CHPh); 4.70 (1 H, m, CHΝHAc); 4.35 (1 H, m, dihydroindole C(2)H); 4.2 (2H, s, CH 2 ΝH 2 ) ; 4.2 (IH, m, dihydroindole C(2)H); 3.2 (2 H, t, J = 8 Hz, dihydroindole C(3)H 2 ); 2.0 (3 H, s, COCH 3 ) ; 1.4 (3 H, d, J " = 7 Hz, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.19 minutes. LC/MS (Luna 2, Gradient 4) : rt = 1.67 minutes, 514 (MH) + . Example 42 3- (Aminomethyl) benzoyl-D-phenylglycine 1-aminoacetyl- 2, 3 -dihydroindol-6-amide bis (trifluoroacetate) salt Prepared using glycine. X H NMR (d 4 MeOH): 8.41 (1 H, s, dihydroindole C(7)H); 7.97 (2 H, br s, Ar) ; 7.58 (4 H, m, Ar) ; 7.22 (1 H, d, J = 8 Hz, Ar) ; 5.84 (1 H, s, CHPh); 4.20 (2 H, s, CH 2 NH 2 ) ; 4.15 (2 H, t, J = 9 Hz, dihydroindole C(2)H); 4.04 (2 H, s, COCH 2 NH 2 ) ; 3.23 (2H, t, J = 9 Hz, dihydroindole C(3)H). HPLC (Luna 2, Gradient 1): rt = 2.77 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.24 minutes, 458 (MH) + . Example 43 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (3- methylbutanoyl) -2 , 3 -dihydroindol- 6 -amide trifluoroacetate salt Prepared using 3-methylbutanoyl chloride. X H NMR (d 4 MeOH): 8.40 ppm (1 H, s, Ar) ; 8.02 (2 H, m, Ar) ; 7.67 (4 H, m, Ar) ; 7.22 (1 H, d, J = 11 Hz, Ar) ; 5.90 (1 H, s, CHPh); 4.27 (2 H, s, CH 2 NH 2 ) ; 4.22 (2 H, t, J = 8 Hz, indoline C(2)H 2 ); 3.22 (2H, t, J " = 8 Hz, indoline C(3)H 2 ); 2.45 (2 H, d, J " = 7 Hz, COCH 2 ) ; 2.28 (1 H, septet, J " = 7 Hz, CHMe 2 ) ; 1.1 (6 H, d, J = 7 Hz, CH(CH 3 ) 2 ). HPLC (Luna 2, Gradient 1): rt = 4.18 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.15 minutes, 485 (MH) + . Example 44 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (benzyloxy) - acetyl-2, 3 -dihydroindol-6-amide trifluoroacetate salt Prepared using 2-benzyloxyacetyl chloride. X H NMR (d 4 MeOH): 8.40 ppm (1 H, s, Ar) ; 8.02 (2 H, m, Ar) ; 7.65 (5 H, m, Ar) ; 7.45 (10 H, m, Ar) ; 7.22 (1 H, d, J = 10 Hz, Ar) ; 5.91 (1 H, s, CHPh); 4.73 (2 H, s, COCH); 4.35 (1 H, q, CHNH 2 ) ; 4.37 (2 H, s, CH 2 Ph) ; 4.25 (2 H, s, CH 2 NH 2 ) ; 4.12 (2 H, t, J = 7.5 Hz, indoline C(2)H 2 ) ; 3.2 (2 H, t, J = 7.5 Hz, indoline C(3)H 2 ). HPLC (Luna 2, Gradient 1): rt = 4.25 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.15 minutes, 549 (MH) + . Example 45 3- (Aminomethyl) benzoyl-D-phenylglycine 1-L-threoninoyl- 2, 3 -dihydroindol-6-amide bis (trifluoroacetate) salt Prepared using L-threonine. 'H NMR (d 4 MeOH): 8.31 ppm (1 H, s, Ar) ; 7.80 (2 H, m, Ar) ; 7.45 (4 H, m, Ar) ; 7.25 (4 H, m, Ar) ; 7.05 (1 H, d, Ar) ; 5.65 (1 H, s, CHPh); 4.10 (2 H, t, J = 8 Hz, indoline C(2)H 2 ); 4.02 (2 H, s, CH 2 NH 2 ) ; 3.11 (2 H, t , J = 8 Hz , indoline C(3)H 2 ); 1.21 (3H, d, CH 3 ) ; other signals obscured by solvent . HPLC (Luna 2, Gradient 1): rt = 2.84 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.65 minutes, 502 (MH) + . Example 46 3- (Aminomethyl) benzoyl-D-phenylglycine 1-L-prolinoyl- 2, 3 -dihydroindol- -amide bis (trifluoroacetate) salt Prepared using L-proline. X H NMR (d 4 MeOH): 8.47 ppm (1 H, s, Ar) ; 8.05 (2 H, m, Ar) ; 7.75 - 7.65 (4 H, m, Ar) ; 7.56 - 7.47 (4 H, m, Ar) ; 7.30 (1 H, d, J " = 9 Hz, Ar) ; 5.91 (1 H, s, CHPh); 4.73 (1 H, t, J " = 6.5 Hz, proline C(2)H); 4.25 (4 H, m, CH 2 NH 2 and indoline C(2)H 2 ); 3.65-3.32 (3 H, m, indoline C(3)H 2 and proline C(5)H); 2.70 (1 H, m, proline C(5)H); 2.33 - 2.15 (4 H, m, proline C(3)H 2 and C(4)H 2 ). HPLC (Luna 2, Gradient 1): rt = 2.98 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.59 minutes, 498 (MH) + . Example 47 3- (Aminomethyl) benzoyl-D-phenylglycine 1- ( (S) -2-hydroxypropanoyl) -2, 3 -dihydroindol-6 -amide trifluoroacetate salt Prepared using ( S) -2-hydroxypropanoic acid. 'H NMR (d 4 MeOH): 8.33 ppm (1 H, s, Ar) ; 7.97 (2 H, m, Ar) ; 7.66 - 7.56 (4 H, m, Ar) ; 7.45 - 7.37 (4 H, m, Ar) ; 7.18 (1 H, d, J = 9 Hz, Ar) ; 5.83 (1 H, s, CHPh); 4.58 (IH, m, CHOH); 4.31 (IH, m, indoline C(2)H); 4.21 (2 H, s, CH 2 NH 2 ) ; 4.15 (1 H, m, indoline C(2)H); 3.18 (2 H, t, J = 8 Hz, indoline C(3)H 2 ); 1.4 (3 H, d, J " = 7 Hz, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.31 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.72 minutes, 473 (MH) + . Example 48 3- (Aminomethyl) benzoyl-D-phenylglycine 1-D-prolinoyl- 2, 3 -dihydroindol-6-amide bis (trifluoroacetate) salt Prepared using D-proline. 'H NMR (d 4 MeOH): 8.41 ppm (1 H, s, Ar) ; 7.97 (2 H, m, Ar) ; 7.64 - 7.57 (4 H, m, Ar) ; 7.48 - 7.39 (4 H, m, Ar) ; 7.23 (1 H, d, J " = 11 Hz, Ar) ; 5.82 (1 H, s, CHPh); 4.63 (1 H, m, proline C(2)H); 4.24 (4 H, m, CH 2 NH 2 and indoline C(2)H 2 ); 3.52-3.24 (3 H, m, indoline C(3)H 2 and proline C(5)H); 2.63 (1 H, m, proline C(5)H); 2.23 - 2.08 (4 H, m, proline C(3)H 2 and C(4)H 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.98 minutes. HPLC (Symmetry, Gradient 2): rt = 4.87 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.59 minutes, 498 (MH) + . Example 49 3- (Aminomethyl)benzoyl-D-phenylglycine l-L-serinoyl-2, 3- dihydroindol-6-amide bis (trifluoroacetate) salt Prepared using L-serine. 'H NMR (d 4 MeOH): 8.40 ppm (1 H, s, Ar) ; 7.95 (2 H, m, Ar) ; 7.64 - 7.57 (4 H, m, Ar) ; 7.47 - 7.39 (4 H, m, Ar) ; 7.23 (1 H, d, J = 10 Hz, Ar) ; 5.81 (1 H, s, CHPh); 4.4 (1 H, dd, J = 12 Hz, 4 Hz, serine CH a H b OH) ; 4.25 (2 H, t, -7 = 7 Hz, indoline C(2)H 2 ); 4.20 (2 H, s, CH 2 NH 2 ) ; 4.05 (1 H, dd, J = 12, 6 Hz, serine CH a H b OH) ; 3.91 (1 H, m, serine CHNH 2 ) ; 3.25 (2 H, t, -7 = 7 Hz, indoline C(3)H 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.84 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.35 minutes, 488 (MH) + . Example 50 3- (Aminomethyl) benzoyl-D-phenylglycine l-D-serinoyl-2, 3- dihydroindol-6-amide bis (trifluoroacetate) salt Prepared using D-serine. "H NMR (d 4 MeOH): 8.42 ppm (1 H, s, Ar) ; 7.97 (2 H, m, Ar) ; 7.64 - 7.57 (4 H, m, Ar) ; 7.47 - 7.39 (4 H, m, Ar) ; 7.23 (IH, d, J = 9 Hz, Ar) ; 5.82 (1 H, s, CHPh); 4.41 (1 H, dd, J = 12, 4 Hz, serine CH a H b OH) ; 4.25 (2 H, t, J = 7.5 Hz, indoline C(2)H 2 ); 4.2 (2 H, s, CH 2 NH 2 ) ; 4.05 (1 H, dd, J = 12, 6 Hz, serine CH a H b OH) ; 3.9 (1 H, mserine CHNH 2 ) ; 3.25 (2 H, t, -7 = 7.5 Hz, indoline C(3)H 2 ). HPLC (Luna 2, Gradient 1): rt = 2.78 minutes. HPLC (Symmetry, Gradient 2): rt = 4.61 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.65 minutes, 488 (MH) + . Example 51 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (3 -pyridyl- acetyl) -2, 3 -dihydroindol-6 -amide bis (trifluoroacetate) salt Prepared using 3-pyridylacetic acid. X H NMR (d 3 acetonitrile): 8.91 ppm (1 H, br s, Ar) , 8.73-8.55 (2 H, m, Ar) , 8.35 (1 H, br s, Ar) , 8.15 (1 H, d, J = 10 Hz, Ar) , 8.05-7.95 (2 H, m, Ar) , 7.80 (IH, d, J " = 10 Hz, Ar) , 7.74 - 7.15 (10 H, m, Ar & 2 x amide NH) , 5.69 (1 H, d, J = 1 Hz, CHPh), 4.25 - 4.12 (4 H, m, ArCH 2 N & dihydroindole C(2)H 2 ), 3.98 (2 H, s, C(0)CH 2 Py), 3.17 (2 H, t, J = 8 Hz, dihydroindole C(3)H 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.96 minutes. LC/MS (Luna 2, Gradient 4) : rt = 1.35 minutes, 520 (MH + ) . Example 52 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (W-acetyl) - aminoacetyl-2,3 -dihydroindol-6-amide trifluoroacetate salt Prepared using N-acetylglycine . 'H ΝMR (d 4 MeOH): 8.31 ppm (1 H, s, Ar) ; 7.95 (2 H, m, Ar) ; 7.64 - 7.57 (4 H, m, Ar) ; 7.43 - 7.38 (4 H, m, Ar) ; 7.18 (IH, d, J " = 10 Hz, Ar) ; 5.81 (IH, S, CHPh); 4.23 - 4.11 (6 H, m, ArCH 2 ΝH 2 , aminoacetyl CH 2 and dihydroindole C(2)H 2 ); 3.21 (2 H, t, J = 1 Hz, dihydroindole C(3)H 2 ); 2.07 (3H, s, COCH 3 ) . HPLC (Luna 2, Gradient 1): rt = 3.33 minutes. HPLC (Symmetry, Gradient 2): rt = 5.20 minutes. LC/MS (Luna 2, Gradient 4): rt = 0.59 minutes, 500 (MH) + . Example 53 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (hydroxyacetyl) -2 , 3 -dihydroindol-6 -amide trifluoroacetate salt Prepared using 2-benzyloxyacetic acid. 'H NMR (d 4 MeOH): 8.25 ppm (1 H, s, Ar) ; 7.85 (2 H, m, Ar) ; 7.54 - 7.47 (4 H, m, Ar) ; 7.35 - 7.26 (4 H, m, Ar) ; 7.10 (1 H, d, J = 11 Hz, Ar) ; 4.21 (2 H, s, CH 2 OH ); 4.10 (2 H, s, CH 2 NH 2 ) ; 3.95 (2 H, t, J = 7.5 Hz, dihydroindole C(2)H 2 ); 3.21 (2 H, t, J " = 7.5 Hz, dihydroindole C(3)H 2 ). HPLC (Luna 2, Gradient 1): rt = 3.23 minutes. HPLC (Symmetry, Gradient 2): rt = 5.26 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.67 minutes, 500 (MH) + . Example 54 3- (Aminomethyl) benzoyl-D-phenylglycine 1-phenylacetyl- 2, 3 -dihydroindol-6-amide trifluoroacetate salt Prepared using phenylacetic acid. *H NMR (d 3 acetonitrile): 8.78 (1 H, br s, Ar) , 8.23 (1 H, br s, Ar) , 7.90 (2 H, s, Ar) , 7.73 (IH, d, J " = 10 Hz, Ar) , 7.60 - 7.01 (14 H, m, Ar & 2 x amide NH) , 5.60 (1 H, d, J = 1 Hz, CHPh), 4.10 - 3.97 (4 H, m, ArCH 2 N & dihydroindole C(2)H 2 ), 3.71 (2 H, s, PhCH 2 ) , 2.99 (2 H, t, J = 8 Hz, dihydroindole C(3)H 2 ). HPLC (Luna 2, Gradient 1): rt = 4.17 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.26 minutes, 519 (MH + ) . Example 55 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (methylamino) - acetyl-2, 3 -dihydroindol-6-amide bis (trifluoroacetate) salt Prepared using sarcosine. X H NMR (d 4 MeOH): 8.39 ppm (1 H, s, indoline C(7)H); 7.95 (2 H, br s, 3- (aminomethyl) phenyl C(2)H and C(6)H); 7.72 - 7.53 (4 H, m, Ar) ; 7.47 - 7.31 (4 H, m, Ar) ; 7.24 (1 H, d, J " = 10 Hz, indoline C(4)H or C(5)H); 5.82 (1 H, br s, CHPh); 4.20 (2 H, s, CH 2 NH 2 or C (0) CH 2 NHMe) ; 4.15 (2 H, s, CH 2 NH 2 or C(0)CH 2 NHMe) ; 4.10 (2 H, t, J = 9 Hz, indoline C(2)H 2 ); 3.25 (2 H, t, J = 9 Hz, indoline C(3)H 2 ); 2.81 (3 H, s, CH 3 ) . HPLC (Symmetry C8, Gradient 2): rt = 4.75 min. LCMS (Luna 2, Gradient 4): rt = 1.45 min, 472 (MH) + . Example 56 3- (Aminomethyl) benzoyl-D-phenylglycine 3-aminopropionyl- 2, 3 -dihydroindol-6-amide bis (trifluoracetate) salt Prepared using β-alanine. 'H NMR (D 2 0) : 7.98 ppm (1 H, s, indoline C(7)H); 7.72 (2 H, br s, 3- (aminomethyl) phenyl C(2)H and C(6)H); 7.60 - 7.30 (7 H, m, Ar) ; 7.08 (1 H, d, J " = 10 Hz, indoline C(4)H or C(5)H); 6.95 (1 H, d, J = 10 Hz, indoline C(4)H or C(5)H); 5.57 (1 H, s, CHPh); 4.09 (2 H, s, ArCH 2 NH 2 ) ; 3.82 (2 H, t, J = 7 Hz, indoline C(3)H 2 ); 3.20 (2 H, t, J = 4.5 Hz, C(0)CH 2 CH 2 NH 2 ) ; 2.95 (2 H, t, J = 1 Hz, indoline C(3)H 2 ); 2.71 (2 H, t, J = 4.5 Hz, C (0) CH 2 CH 2 NH 2 ) . HPLC (Symmetry C8, Gradient 2): rt = 4.80 minutes. LCMS (Luna 2, Gradient 4): rt = 1.53 minutes, 472 (MH) + . Example 57 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (4-pyridyl- acetyl) -2, 3 -dihydroindol-6 -amide bis-trifluoroacetate salt Prepared using 4-pyridylacetic acid. 'H NMR (CD 3 CN) : 8.91 (1 H, br s, Ar) , 8.73-8.55 (2 H, m, Ar) , 8.35 (1 H, br s, Ar) , 8.15 (1 H, d, J " = 10 Hz, Ar) , 8.05- 7.95 (2 H, m, Ar) , 7.80 (IH, d, J = 10 Hz, Ar) , 7.74 - 7.15 (10 H, m, Ar & 2 x amide NH) , 5.69 (1 H, d, J " = 7 Hz, CHPh), 4.25 - 4.12 (4 H, m, PhCH 2 N & dihydroindole C(2)H 2 ), 3.98 (2 H, s, C(0)CH 2 Py), 3.17 (2 H, t, J " = 8 Hz, dihydroindole C(3)H 2 ) . HPLC (Symmetry, Gradient 2): rt = 5.43 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.56 minutes, 520 (MH) + . Example 58 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (imidazol-4- ylacetyl) -2, 3 -dihydroindol-6 -amide bis (trifluoroacetate) salt Prepared using imidazol-4-ylacetic acid. X H NMR (D 2 0) : 7.75 ppm (1 H, br s, NH) ; 7.49 (2 H, br s, Ar) ; 7.28 (1 H, d, J = 8 Hz, Ar) ; 7.24-7.12 (9 H, m, Ar) ; 6.92 (1 H, d, J = 8 Hz, Ar) ; 6.74 (1 H, d, J = 8 Hz, Ar) ; 6.28 (IH, s, NH) ; 5.38 (1 H, s, CHPh); 3.87 (2 H, s, ArCH 2 NH 2 ) ; 3.72 (2 H, d, J " 8 = Hz, dihydroindole C(2)H 2 ); 3.52 (2 H, br s, CH 2 Im) ; 2.70 (2 H, t, J = 8 Hz, dihydroindole C(3)H 2 ). HPLC (Symmetry, Gradient 2): rt = 4.89 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.45 minutes, 509 (MH) + . Example 59 3- (Aminomethyl) benzoyl-D-phenylglycine l-(2- aminothiazol-4-yl) -acetyl-2, 3 -dihydroindol-6-amide dihydrochloride . Prepared using (2-formamidothiazol-4-yl) acetic acid. *H NMR (D 2 0) : 7.77 ppm (1 H, br s, NH) ; 7.51 (2 H, br s, Ar) ; 7.29 (1 H, d, -7 = 8 Hz, Ar) ; 7.24-7.03 (9 H, m, Ar) ; 6.91 (1 H, d, J " = 8 Hz, Ar) ; 6.72 (1 H, d, J " = 8 Hz, Ar) ; 6.22 (IH, s, NH) ; 5.32 (1 H, s, CHPh); 3.85 (2 H, s, ArCH 2 NH 2 ) ; 3.73 (2 H, d, J = 8 Hz, dihydroindole C(2)H 2 ); 3.56 (2 H, br s, CH 2 Thz) ; 2.76 (2 H, t, J = 8 Hz, dihydroindole C(3)H 2 ). HPLC (Symmetry, Gradient 2): rt = 5.03 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.51 minutes, 541 (MH) + . Example 60 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (2- formylaminothiazol-4-yl) acetyl-2, 3 -dihydroindol- 6 -amide trifluoroacetate salt Prepared using (2-formylaminothiazol-4-yl) acetic acid. 'H NMR (D 2 0) : 8.30 ppm (1 H, s, NCHO) ; 7.90 (1 H, br s, ArNH) ; 7.64 (2 H, br s, Ar) ; 7.42 (1 H, d, J = 8 Hz, Ar) ; 7.38 - 7.26 (9 H, m, Ar & NH) ; 7.01 (I H, d, -7 = 8 Hz, Ar) ; 6.96 (1 H, d, J " = 8 Hz, Ar) ; 6.82 (IH, s, NH) ; 5.50 (1 H, s, CHPh); 4.06 (2 H, s, ArCH 2 NH 2 ) ; 3.90 (2 H, d, J = 8 Hz , dihydroindole C(2)H 2 ); 3.64 (2 H, br s, CH 2 Thz) ; 2.90 (2 H, t, J = 8 Hz, dihydroindole C(3)H 2 ). HPLC (Symmetry, Gradient 2): rt = 5.75 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.10 minutes, 569 (MH) + . Example 61 3- (Aminomethyl) benzoyl-D/L- (4-aminomethyl) phenylglycine indan-5-amide bis (trifluoroacetate) salt. Methyl 4-bromophenylacetate Thionyl chloride (18 mL, 0.25 mol) was added dropwise to a solution of 4-bromo-phenylacetic acid (50 g; 0.23 mol) in methanol (250 mL) . The resulting mixture was stirred at room temperature for 1 hour before the methanol was removed in vacuo. Ethyl acetate (300 mL) was added and the resulting solution was washed with water (3 x 150 mL) and 1M aqueous NaHC0 3 (1 x 150 mL) , dried (MgS0 4 ) and evaporated to give the ester (52.8 g; 100 %) as an orange oil which was used without further purification. X H NMR (CDC1 3 ) : 7.38 ppm (2 H, d, J = 8.4 Hz, C(2)H and C(6)H) ; 7.09 (2 H, d, J = 8.4 Hz, C(3)H and C(5)H) ; 3.63 (3 H, s, OMe); 3.51 (2 H, s, CH 2 ) . Methyl 4-cyanophenylacetate Zinc cyanide (10.4 g, 0.088 mol) and tetrakis- (triphenylphosphine) palladium (0) (5 g, 4.4 mmol) were added to a solution of methyl 4-bromophenylacetate (20 g, 0.088 mol) in dimethylformamide (150 mL) . The resulting mixture was stirred at 80°C for 5 hours, then allowed to cool to room temperature. Toluene (500 mL) and 1M aqueous ammonia (500 mL) were added, the layers were separated and the organic layer washed with brine (100 mL) and dried (MgS0 4 ) . Evaporation of the solvents afforded an off-white solid, which was purified by silica gel chromatorgraphy to afford the cyano-compound as a white solid (11.3 g; 73 %) . "H NMR (CDC1 3 ) : 7.65 ppm (2 H, d, J " = 8.4 Hz, C(3)H and C(5)H); 7.42 (2 H, d, J = 8.1 Hz, C(2)H and C(6)H) ; 3.74 (3H, s, OMe) ; 3.72 (2H, s, CH 2 ) . 4-Cyanophenylacetic acid A solution of methyl 4-cyanophenylacetate (23.9 g; 0.136 mol) in ethanol (250 mL) was stirred at room temperature and a solution of sodium hydroxide (6.0 g; 0.15 mol) in water (25 mL) was added. After 2 hours the ethanol was removed in vacuo. Ethyl acetate (300 mL) and 5% aqueous HCl (300 mL) were added and the layers were separated. The aqueous layer was extracted with ethyl acetate (300 mL) and the combined organic layers were dried (MgS0 4 ) and evaporated in vacuo to give the acid (21.6 g; 99 %) which was used without further purification. *H NMR (CDC1 3 ) : 7.57 ppm (2 H, d, J = 8.3 Hz, C(3)H and C(5)H) ; 7.34 (2 H, d, J = 8.2 Hz, C(2)H and C(6)H) ; 3.64 (2 H, s , CH 2 ) . 4- (W-BOC-aminomethyl)phenylacetic acid A solution of 4-cyanophenylacetic acid (12.11 g, 0.075 mol) in water (163 mL) and concentrated aqueous ammonia (40 mL) was stirred at room temperature and Raney nickel (6.3 g) was added. The resulting suspension was stuirred under a hydrogen atmosphere for 24 hours before the reaction mixture was filtered through celite and evaporated in vacuo to give crude 4- (aminomethyl) -phenylacetic acid (12.57 g; 100 %) as a pale blue solid. A solution of the crude amino acid (12.57 g, 0.075 mol) in water (50 mL) and 1,4-dioxane (50 mL) was stirred at room temperature and sodium hydroxide (3 g, 0.075 mol) and di- ""butyl dicarbonate (16.4 g, 0.075 mol) were added simultaneously. After 24 hours the 1,4-dioxane was removed in vacuo and the aqueous layer was acidified with saturated aqueous citric acid (200 mL) . The solution was extracted with ethyl acetate (3 x 150 mL) and the combined organic layers were dried (MgS0 4 ) and evaporated in vacuo to give the N-BOC-amine (17.6 g, 88 %) as a white solid which was used without further purification. 'H ΝMR (CDC1 3 ) : 7.00 ppm (4 H, m, Ar) ; 4.65 (1 H, br s, Ν-H) ; 4.09 (2 H, d, J " = 6 Hz, CH 2 ΝH) ; 3.43 (2H, s, CH 2 ) ; 1.25 (9H, s, fc Bu) . Methyl 4- (N-BOC-aminomethyl)phenylacetate 1- [3- (Dimethylamino) propyl] -3-ethylcarbodiimide hydrochloride (34.8 g, 0.18 mol) and 4 - (N, N- dimethylamino) pyridine (220 mg, 1.8 mmol) were added to a solution of 4- (N-BOC-aminomethyl) phenylacetic acid (47.8 g, 0.18 mol) in methanol (200 ml) . After stirring for 18 hours the methanol was removed in vacuo and the reaction mixture partitioned between ethyl acetate (200 mL) and saturated aqueous citric acid (200 mL) . The organic phase was separated and washed with saturated aqueous ΝaHC0 3 (200 mL) and brine (200 mL) , dried (MgS0 4 ) and evaporated to give the methyl ester (49.8 g; 99 %) . 'H NMR (CDC1 3 ) : 7.42 ppm (4 H, S, Ar) ; 5.02 (1 H, br s, N-H) ; 4.48 (2 H, d, J = 5.7 Hz, CH 2 NH) ; 3.87 (3 H, s, OMe) ; 3.79 (2 H, s, CH 2 ) ; 1.64 (9 H, s, c Bu) . Methyl [4- (N-BOC-aminomethyl) phenyl] -α-azidoacetate A solution of methyl 4- (N-BOC-aminomethyl) phenylacetate (9.34 g; 0.033 mol) in THF (100 mL) was stirred under argon at -78°C and potassium bis (trimethylsilyl) amide (16.7 g, 0.084 mol) in THF (50 mL) was added. After stirring for 30 minutes, 2 , 4 , 6-triisopropylbenzene-sulfonyl azide (31.1 g, 0.101 mol) was added as a solid. After 5 minutes, acetic acid (10 mL, 0.175 mol) was added and the reaction warmed to room temperature. The reaction mixture was then partitioned between ethyl acetate (500 mL) and water (500 mL) , separated and the organic layer dried (MgS0 4 ) . Evaporation of the solvent and purification of the residue by silica gel chromatography afforded the azide (7.1 g, 67 %) . H NMR (CDC1 3 ) : 7.28 ppm (4 H, s, Ar) ; 4.92 (1 H, s, CHN 3 ) ; 4.25 (2 H, s, CH 2 NH) ; 3.69 (3 H, s, OMe); 1.38 (9 H, s, 'Bu) . Methyl α-amino- [4- (N-BOC-aminomethyl) phenylacetate A solution of methyl [4- (N-BOC-aminomethyl) phenyl] -α- azidoacetate (7.1 g, 0.022 mol) in ethyl acetate (50 mL) was stirred over palladium on carbon (5%) . The reaction vessel was taken up to 250 psi with hydrogen for 17 hours. The reaction mixture was filtered through celite and evaporated in vacuo to give the amine (6.47 g, 100 %) as a pale solid. 1 H ΝMR (CDC1 3 ) : 7.20 ppm (2 H, m, Ar) ; 7.12 (2 H, m, Ar) ; 4.81 (1 H, br s, ΝH) ; 4.45 (1 H, s, CH) ; 4.18 (2 H, d, J " = 6 Hz, CH 2 ΝH) ; 3.54 (3 H, s, OMe) ; 2.09 (2 H, br s, NH 2 ) ; 1.30 (9 H, s, fc Bu) . Methyl α- (W-benzyloxycarbonyl- amino) - [4- (N-BOC- aminomethyl) phenyl] acetate A solution of the amine (530 mg, 1.8 mmol) in tetrahydrofuran (15 mL) was treated with triethylamine (0.25 mL, 1.8 mmol) and benzyl chloroformate (0.26 mL, 1.8 mmol) and allowed to stir at room temperature for 1 hour. The reaction was diluted with ethyl acetate (40 mL) , washed with brine (2 x 25 mL) , dried (MgS0 4 ) and concentrated under reduced pressure to afford a yellow oil. The benzyloxycarbonyl ester was purified by flash chromatography on silica gel (ethyl acetate / hexane 1 : 1) to give a yellow solid (312 mg, 66 %) . X H NMR (CDC1 3 ) : 7.32 - 7.15 ppm (9 H, m, 9 Ar) ; 5.80 (1 H, br S, NH) ; 5.30 (1 H, d, J " = 9.6 Hz, CH) ; 5.01 (2 H, S, CH 2 Ph) ; 4.22 (2 H, d, J = 7.2 Hz, CH 2 NHBoc) ; 3.63 (3 H, s, OCH3); 1.39 (9 H, s, ε Bu) . D/L-α- (N-benzyloxycarbonyl) - [4- (N-BOC-aminomethyl ) phenyl] glycine A solution of the ester (356 mg, 0.83 mmol) in tetrahydrofuran (15 mL) was treated with 1 M LiOH (1.7 mL, 1.7 mmol) and heated at reflux for 3 hours. The solvent was removed under reduced pressure and the residue diluted with water (20 mL) . The pH was reduced to 4 using 5 % aqueous HCl and the aqueous phase was extracted with ethyl acetate (3 x 20 mL) . The combined organic extracts were dried (MgS0 4 ) and concentrated under reduced pressure to afford the acid as a yellow solid (273 mg, 79 %) which was carried forward without further purification. D/L-α- (N-benzyloxycarbonyl ) - [4- (N-BOC- aminomethyl) phenyl] glycine indan-5-amide. A solution of the acid (173 mg, 0.42 mmol) in dimethylformamide (15 ml) was treated with l-(3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (80 mg, 0.42 mmol), l-hydroxy-7-azabenzotriazole (57 mg, 0.42 mmol), 5-aminoindane (56 mg, 0.42 mmol) and 4 - (N, N- dimethylamino) pyridine (5 mg) and stirred overnight at room temperature before being partitioned between ethyl acetate (50 mL) and water (50 mL) . The layers were separated and the organic phase was washed with 5 % aqueous HCl (25 mL) , saturated aqueous ΝaHC0 3 (25 mL) and water (25 mL) , dried (MgS0 4 ) and concentrated under reduced pressure to afford the indanamide as a colourless solid (160 mg, 72 %) which was used without further purification. X H NMR (CDC1 3 ) : 7.39 - 7.09 ppm (12 H, m, 10 Ar and 2 NH) ; 6.99 (2 H, s, Ar) ; 5.38 (1 H, br s, CHAr) ; 5.01 (2 H, s, CH 2 Ph) ; 4.81 (1 H, m, NH) ; 4.19 (2 H, s, CH 2 NHBOC) ; 2.85 - 2.68 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.04 - 1.88 (2 H, m, indane C(2)H 2 ); 1.39 (9 H, s, fc Bu) . 3- (N-BOC-Aminomethyl) benzoyl-D/L-4- (N-BOC-aminomethyl) - phenylglycine indan-5-amide 10 % Palladium on carbon (50 mg) , was added to a solution of the indanamide (160 mg, 0.3 mmol) in ethanol (20 mL) and the suspension was stirred under a hydrogen atmosphere overnight . The mixture was filtered and the filter was washed with ethanol (20 ml) . The combined filtrates were concentrated under reduced pressure to afford the amine as a colourless solid (107 mg, 90 %) which was carried forward without further purification. A solution of the amine (107 mg, 0.27 mmol) in dimethylformamide (15 mL) was treated with l-(3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (52 mg, 0.27 mmol), l-hydroxy-7-azabenzotriazole (37 mg, 0.27 mmol), N-BOC-3- (aminomethyl) benzoic acid (68 mg, 0.27 mmol) and 4- (N, N-dimethylamino) yridine (5 mg) and stirred overnight at room temperature. The solution was partitioned between ethyl acetate (25 mL) and water (25 mL) and the organic phase was separated and washed with 5 % aqueous HCl (25 mL) , saturated aqueous ΝaHC0 3 (25 mL) and water (25 mL) before being dried (MgS0 4 ) and concentrated under reduced pressure to afford a yellow solid. The residue was purified by flash chromatography on silica gel (ethyl acetate / hexane 1 : 1) to give the diprotected bis-amide as a colourless solid (103 mg, 61 %) . X H NMR (CDC1 3 ) : 9.25 ppm (1 H, s, NH) ; 7.94 (1 H, d, J " = 7.2 Hz, Ar) ; 7.62 (2 H, s, Ar) ; 7.43 - 7.24 (5 H, m, 4 Ar, NH) ; 7.05 (3 H, d, J = 7.2 Hz, Ar) ; 6.94 (1 H, d, J " = 7.2 Hz, Ar) ; 6.14 (1 H, d, J = 7.2 Hz, CH) ; 5.07 (1 H, m, NH) ; 4.99 (1 H, m, NH) ; 4.16 (2 H, s, CH 2 NHBOC) ; 4.10 (2 H, s, CH 2 NHBOC) ; 2.77 - 2.61 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 1.98 - 1.87 (2 H, m, indane C(2)H 2 ); 1.35 (9 H, s, fc Bu) . 3- (Aminomethyl)benzoyl-D/L-4- (aminomethyl) phenylglycine indan-5-amide bis (trifluoroacetate) salt. A solution of the diprotected bis-amide (103 mg, 0.16 mmol) in dichloromethane (5 mL) was stirred at room temperature and trifluoroacetic acid (3 mL) was added. Stirring was continued for a further hour before the solvents were removed under reduced pressure to afford the bis (trifluoroacetate) salt as a colourless solid (92 mg, 88 %) . X H NMR (d 4 MeOH): 7.90 ppm (1 H, s, Ar) ; 7.84 (1 H, s, Ar) ; 7.65 - 7.54 (4 H, m, Ar) ; 7.49 - 7.32 (3 H, m, Ar) ; 7.12 (1 H, d, J = 7.2 Hz, Ar) ; 7.02 (1 H, d, J = 7.2 Hz, Ar) ; 5.78 (1 H, s, CHAr) ; 4.08 (2 H, s, CH 2 NH 2 ) ; 4.01 (2 H, s, CH 2 NH 2 ) ; 2.79 - 2.70 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.03 - 1.90 (2 H, m, indane C(2)H 2 ). HPLC (Luna 2, Gradient 1): rt = 3.13 minutes. LCMS (Luna 2, Gradient 4): rt = 1.45 minutes, 429 (MH) + . Examples 62 - 64 were prepared in a similar fashion to Example 61, using the specified amine in place of 5- aminoindane . Example 62 3- (Aminomethyl) benzoyl-D/L-4- (aminomethyl) phenylglycine 1-aminoacetyl-2,3-dihydroindol-6 -amide tris (trifluoroacetate salt) Prepared from 6-amino-l- (N-BOC-aminoacetyl) -2 , 3- dihydroindole. *H ΝMR (d 4 MeOH): 8.23 ppm (1 H, s, Ar) ; 7.84 - 7.74 (2 H, m, Ar) ; 7.56 - 7.30 (6 H, m, Ar) ; 7.17 (1 H, d, J " = 7.2 Hz, Ar) ; 7.02 (1 H, d, J = 7.2 Hz, Ar) ; 5.68 (1 H, s, CHAr); 4.02 (2 H, s, CH 2 ΝH 2 ) ; 3.99 - 3.79 (6 H, m, CH 2 NH 2 , dihydroindole C(2)H 2 , CH 2 NH 2 glycine) ; 3.06 - 2.97 (2 H, m, dihydroindole C(3)H 2 ) . HPLC (Luna 2, Gradient 1): rt = 2.13 minutes. LCMS (Luna 2, Gradient 4): rt = 0.51 minutes, 487 (MH) + . Example 63 3- (Aminomethyl) benzoyl-D/L-4- (aminomethyl) phenylglycine 1- acetyl-2, 3 -dihydroindole bis (trifluoroacetate) salt Prepared from l-acetyl-6-amino-2, 3 -dihydroindole . 'H NMR (d 4 MeOH): 8.21 ppm (1 H, s, Ar) ; 7.97 - 7.86 (2 H, m, Ar) ; 7.72 - 7.43 (6 H, m, Ar) ; 7.32 (1 H, d, J = 7.2 Hz, Ar) ; 7.12 (1 H, d, J " = 7.2 Hz, Ar) ; 5.81 (1 H, s, CHAr) ; 4.17 (1 H, S, CH 2 NH 2 ) ; 4.15 - 4.04 (4 H, m, CH 2 NH 2 , dihydroindole C(2)H 2 ); 3.19 - 3.07 (2 H, m, dihydroindole C(3)H 2 ); 2.20 (3 H, S, NC0CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 2.72 minutes. LCMS (Luna 2, Gradient 4) : rt = 1.18 minutes, 472 (MH) + . Example 64 3- (Aminomethyl) benzoyl-D/L-4- (aminomethyl) phenylglycine 4- (isopropyl) phenylamide bis (trifluoroacetate salt) Prepared from 4-isopropylaniline . *H NMR (d 4 MeOH): 8.01 - 7.92 ppm (2 H, m, Ar) ; 7.75 - 7.43 (8 H, m, Ar) ; 7.18 (2 H, d, J " = 9.6 Hz, Ar) ; 5.87 (1 H, s, CHAr) ; 4.21 (2 H, S, CH 2 NH 2 ) ; 4.14 (2 H, S, CH 2 NH 2 ) ; 2.96 - 2.81 (1 H, m, CH(CH 3 ) 2 ) ; 1.24 (6 H, d, J = 7 Hz, CH(CH 3 ) 2 ) . HPLC (Luna 2, Gradient 1): rt = 3.39 minutes. LCMS (Luna 2, Gradient 4): rt = 1.59 minutes, 431 (MH) + . Examples 65 - 68 were prepared in a similar manner to Example 61 except that the indicated protected amino acid was used in the place of D/L-4- (N-BOC-aminomethyl) -α- (N- benzyloxycarbonyl) phenylglycine . Example 65 3- (Aminomethyl) benzoyl-D-cyclohexylglycine indan-5-amide trifluoroacetate salt Prepared from N-BOC-D-cyclohexylglycine. 'H ΝMR (d 4 MeOH): 7.88 - 7.02 ppm (7 H, m, Ar) ; 4.43 (1 H, d, J = 9 Hz, CH(cHex)); 4.04 (2 H, s, CH 2 ΝH 2 ) ; 2.78 - 2.68 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.04 - 1.82 (4 H, m, indane C(2)H 2 , cHex CH 2 ) ; 1.77 - 1.56 (4 H, m, 2 x cHex CH 2 ) ; 1.36 - 0.95 (5 H, m, 2 x cHex CH 2 and CH) . HPLC (Luna 2, Gradient 1): rt = 4.27 minutes. LCMS (Luna 2, Gradient 4): rt = 2.21 minutes, 406 (MH) + . Example 66 3- (Aminomethyl)benzoyl-D/L-l-naphthylglycine indan-5- amide trifluoroacetate salt Prepared from N-BOC-D/L- 1-naphthylglycine . 'H ΝMR (d 4 MeOH): 8.25 ppm (1 H, d, J = 7.2 Hz, Ar) ; 8.04 - 7.84 (4 H, m Ar) ; 7.75 - 7.44 (7 H, m, Ar) ; 7.33 (1 H, d, J = 7.25 Hz, Ar) ; 7.16 (1 H, d, J " = 7.25 Hz, Ar) ; 6.72 (1 H, s, CHAr); 4.15 (2 H, s, CH 2 ΝH 2 ) ; 2.94 - 2.78 (4 H, m, indane C(1)H 2 C(3)H 2 ); 2.17 - 1.98 (2 H, m, indane C(2)H 2 ). HPLC (Luna 2, Gradient 1): rt = 4.37 minutes. LCMS (Luna 2, Gradient 4): rt = 2.37 minutes, 450 (MH) + . Example 67 3- (Aminomethyl) benzoyl-D/L- (4 -phenyl) phenylglycine indan-5-amide trifluoroacetate salt Prepared from N-Fmoc-D/L- (4 -phenyl) phenylglycine . 'H ΝMR (d 4 MeOH): 7.94 - 7.83 ppm (2 H, m, Ar) ; 7.64 - 7.15 (13 H, m, Ar) ; 7.02 (1 H, d, J = 7.2 Hz, Ar) ; 5.80 (1 H, s, CH) ; 4.08 (2 H, s, CH 2 ΝH 2 ) ; 2.81 - 2.77 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.01 - 1.88 (2 H, m, indane C(2)H 2 ). HPLC (Luna 2, Gradient 1): rt = 4.87 minutes. LCMS (Luna 2, Gradient 4): rt = 2.56 minutes, 476 (MH) + . Example 68 3- (Aminomethyl) benzoyl-D- (4-aminophenyl) glycine indan-5- amide bis (trifluoroacetate) salt Prepared from N-BOC-D- (4 -Benzyloxycarbonylammophenyl ) - glycine (prepared as described below) . D- (4 -Hydroxyphenyl) glycine methyl ester hydrochloride D-4-Hydroxyphenylglycine (12.5 g, 74.8 mmol) and dry methanol (24 mL) were stirred in a dry 250 mL three necked round bottom flask, equipped with a low temperature thermometer. The mixture was stirred under nitrogen and cooled to an internal temperature of below -20°C. Using a syringe, thionyl chloride (6 mL, 9,78 g, 82.2 mmol) was added dropwise to the cooled mixture over a period of 10 minutes at such a rate that the internal temperature did not exceed -20°C. Once the addition was complete the mixture was allowed to warm to room temperature and stirred overnight. Dry ether (150 mL) was added and the white precipitate that formed was collected by suction filtration, washed with a little more ether and dried (15.5g, 95%) . N-BOC-D- (4-Hydroxyphenyl) glycine methyl ester Di-t-butyl dicarbonate (15.9 g, 72.8 mmol) was added to a stirred mixture of D-4-hydroxyphenylglycine methyl ester hydrochloride (14 g, 64.3 mmol) and ΝaHC0 3 (11.7 g, 0.14 mol) in tetrahydrofuran (150 mL) and water (50 mL) , in one portion. The mixture was stirred rapidly for 4h. Hexane (75 mL) was added and the organic layer separated and washed with saturated aqueous NaHC0 3 (20 mL) and brine (20 mL) and dried (MgS0 4 ) . Evaporation of the solvent afforded the N- BOC-protected amine (19.7g, 96%). N-BOC-D- (4-Trifluoromethylsulphonyloxyphenyl) glycine methyl ester 2,6-Lutidine (9.44 ml, 8.68 g, 81.0 mmol) and 4- dimethylaminopyridine (1.65 g, 13.5 mmol) were added to a stirred solution of N-BOC-D- (4-hydroxyphenyl) glycine methyl ester (19 g, 67.5 mmol) in dichloromethane (400 mL) and the mixture cooled in an ice bath. Trifluoromethananesulphonic anhydride (13.7 mL, 23.0 g, 81.4 mmol) was added over a period of five minutes and then the mixture was allowed to warm to room temperature over four hours. The solution was washed with water (2 x 150 mL) , IN HCl (2 x 150 mL) and saturated aqueous NaHC0 3 (150 mL) and dried (MgS0 4 ) . Evaporation of the solvent afforded an oil which was purified by flash chromatography on silica gel (hexane / dichloromethane 1:1 and then neat dichloromethane) affording the triflate as a white solid (19 g, 77%) . N-BOC-D- (4-benzyloxycarbonylphenyl) glycine methyl ester N-BOC-D- (4-trifluoromethylsulphonyloxyphenyl) glycine methyl ester (27.6 g, 77.0 mmol), benzyl alcohol (32.6 mL, 34.1 g, 315 mmol), palladium (II) acetate (255 mg, 1.13 mmol), bis- 1, 3-diphenylphosphinylpropane (448 mg, 1.09 mmol) and triethylamine (10.2 L, 7.40 g, 73.2 mmol) in dimethylformamide (72 mL) were placed in a Parr reactor and the reactor assembled. The vessel was pressurised to -10 psi with nitrogen and the gas released (repeated five times to remove all oxygen from the system) . Carbon monoxide gas was then carefully introduced to -20 psi and released three times. Carbon monoxide was then added to -100 psi and the stirrer started. The vessel was slowly heated to 65 °C internal temperature and then stirred, monitoring by tic. When complete (after - 18 hours) the reaction was cooled to 30°C, the gas released and the vessel flushed five times with nitrogen as before. The reaction mixture was partitioned between ethyl acetate (250 mL) and water (100 mL) and the organic layer washed with 1M hydrochloric acid (30 mL) and saturated aqueous ΝaHC0 3 (30 mL) and dried (MgS0 4 ) and evaporated. Purification of the resulting oil by column chromatography (ethyl acetate / hexane; 1:4) gave the benzyl ester (18.7 g, 70%). N-BOC-D- (4-hydroxycarbonylpheny1) glycine methyl ester 10 % Palladium on carbon (100 mg) was added to a solution of the benzyl ester (500 mg, 1.25 mmol) in ethanol (15 mL) and the suspension was stirred under a hydrogen atmosphere overnight. The mixture was filtered and the residue was washed with ethanol (20 mL) and the combined organic solvents were evaporated under reduced pressure to afford the acid as a colourless solid (363 mg, 94 %) . 'H ΝMR (CDC1 3 ) : 8.08 ppm (2 H, br s, Ar) ; 7.49 (2 H, d, J = 7.2 Hz, Ar) ; 5.87 (1 H, d, -7 = 9 Hz, ΝHCH) ; 3.73 (3 H, s, OCH 3 ) ; 1.41 (9 H, S, fc Bu) . N-BOC-D- (4-Benzyloxycarbonylaminophenyl) glycine methyl ester. The acid (218 mg, 0.7 mmol) in tetrahydrofuran (20 mL) was treated with triethylamine (108 μl , 0.78 mmol) and diphenylphosphonic azide (161 μl, 0.78 mmol) and stirred at room temperature for 1.5 hours. Benzyl alcohol (116 μl , 1.12 mmol) was then added and the mixture was heated at reflux for 18 hours. The solvent was evaporated under reduced pressure and the residue was purified by flash chromatography (ethyl acetate / hexane, 1:1) to give the N- benzyloxycarbonylaniline as a brown solid (87 mg, 30 %) . 'H ΝMR (CDC1 3 ) : 7.35 - 7.23 ppm (7 H, m, Ar) ; 7.16 (2 H, d, J = 9 Hz, Ar) ; 7.06 (1 H, s, ΝH) ; 5.53 (1 H, d, J = 9 Hz, CHAr); 5.18 (1 H, d, J = 9 Hz, ΝH) ; 5.10 (2 H, s, CH 2 Ph) ; 3.59 (3 H, s, OCH 3 ) ; 1.31 (9 H, S, fc Bu) . N-BOC-D- (4-Benzyloxycarbonylaminophenyl) glycine A solution of the ester (87 mg, 0.21 mmol) in tetrahydrofuran (5 mL) was treated with 1 M LiOH (0.84 ml, 0.84 mmol) and heated at reflux for four hours. The solvent was removed under reduced pressure and the residue was diluted with water (10 mL) . The aqueous solution was acidified to pH 4 using 5 % aqueous HCl and extracted with ethyl acetate (3 x 10 mL) . The combined extracts were dried (MgS0 4 ) and evaporated under reduced pressure to afford the crude acid (80 mg, 95 %) as a colourless solid which was carried forward without further purification. 3- (Aminomethyl) benzoyl-D- (4 -aminophenyl) glycine indan-5- amide bis (trifluoroacetate) salt. H NMR (d 4 MeOH): 7.92 - 7.80 ppm (2 H, m, Ar) ; 7.69 (2 H, d, J " = 7.3 Hz, Ar) ; 7.60 - 7.40 (2 H, m, Ar) ; 7.34 (3 H, d, J " = 12 Hz, Ar) ; 7.15 (1 H, d, J = 7.2 Hz, Ar) ; 7.02 (1 H, d, J = 7.2 Hz, Ar); 5.79 (1 H, s, CHAr); 4.07 (2 H, s, CH 2 NH 2 ) ; 2.80 - 2.69 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.01 - 1.88 (2 H, m, indane C(2)H 2 ). HPLC (Luna 2, Gradient 1): rt = 3.17 minutes. LCMS (Luna 2, Gradient 4): rt = 1.59 minutes, 415 (MH) + . Example 69 3- (Aminomethyl) benzoyl-D/L-piperidin-4-ylglycine indan- 5-amide bis (trifluoroacetate) salt (N-BOC-Piperidin-4 -ylidene) - (N-benzyloxycarbonyl) glycine methyl ester N-BOC-4 -Piperidone (2.0 g, 10 mmol), N- (benzyloxy-carbonyl ) - α-phosphonoglycine trimethyl ester (3.64 g, 2.20 mmol) and 1, 8-diazabicyclo [5.4.0] undec-7-ene (1.57 mL, 2.10 mmol) were stirred in acetonitrile overnight. The solvent was removed and the residue taken up in ethyl acetate (50 mL) and washed with water (2 x 10 mL) , dried (MgS0 4 ) and evaporated under reduced pressure. The residual oil was purified by chromatography on silica gel (ethyl acetate / hexane, 40 % / 60 %) to afford the unsaturated ester (3.63 g, 90 %) . X H NMR (CDC1 3 ) : 7.36 ppm (5 H, br s, Ph) ; 6.05 (1 H, br s, NH) ; 5.12 (2 H, s, CH 2 Ph) ; 3.73 (3 H, br s, OMe); 3.50 (4 H, br s, piperidine C(2)H 2 and C(6)H 2 ); 2.86 (2 H, br s, piperidine C(3) H 2 or C(5) H 2 ) ; 2.45 - 2.36 (2 H, m, piperidine C(3) H 2 or C(5) H 2 ) ; 1.47 (9 H, s, fc Bu) . (N-BOC-Piperidin-4 -ylidene) - (N-benzyloxycarbonyl) glycine A solution of the methyl ester (391 mg, 1 mmol) in tetrahydrofuran (10 mL) was treated with 1 M LiOH (2 mL, 2 mmol) and heated at reflux for 4 hours. The solvent was removed under reduced pressure and the residue diluted with water (20 mL) . The aqueous solution was acidified to pH 4 with 5 % aqueous HCl and extracted with ethyl acetate (3 x 20 mL) . The combined organic extracts were dried (MgS0 4 ) and concentrated under reduced pressure to afford the acid as a brown solid (305 mg, 78 %) which was carried forward without further purification. (N-BOC-Piperidin-4 -ylidene) - (N-benzyloxycarbonyl) glycine indan-5-amide A solution of the acid (253 mg, 0.65 mmol) in dimethylformamide (20 mL) was treated with l-(3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (124 mg, 0.65 mmol), l-hydroxy-7-azabenzotriazole (88 mg, 0.65 mmol), 5-aminoindane (86 mg, 0.65 mmol) and 4- (N, N- dimethylamino) pyridine (10 mg) and stirred overnight at room temperature. The solution was partitioned between ethyl acetate (30 mL) and water (30 mL) , separated, and the organic phase was washed with 5 % aqueous HCl (30 mL) , saturated aqueous NaHC0 3 (30 mL) and water (30 mL) , dried (MgS0 4 ) and concentrated under reduced pressure to afford a colourless solid. The crude product was purified by flash chromatography (ethyl acetate / hexane 1 : 1) to afford the indanamide as a colourless solid (215 mg, 65 %) . *H NMR (CDC1 3 ) : 8.31 (1 H, br s, NH) ; 7.43 (9 H, m, 8 Ar, NH) ; 5.01 (2 H, s, CH 2 Ph) ; 3.34 (4 H, br s , piperidine C(2)H 2 and C(6)H 2 ); 2.83 - 2.71 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.54 (2 H, br s, piperidine C(3)H 2 or C(5)H 2 ); 2.23 - 2.14 (2 H, m, piperidine C(3)H 2 or C(5)H 2 ); 2.05 - 1.92 (2 H, m, indane C(2)H 2 ); 1.38 (9 H, s, fc Bu) . D/L- (N-BOC-Piperidin-4 -yl) glycine indan-5-amide 10 % Palladium on carbon (50 mg) was added to a solution of the alkene (215 mg, 0.43 mmol) in ethanol (20 mL) and the suspension was stirred under a hydrogen atmosphere overnight. The mixture was filtered and the filtrand was washed with ethanol (20 ml) before the combined solvents were concentrated under reduced pressure to afford the deprotected saturated amine as a colourless oil (97 mg, 60 %) . The crude amine was carried forward without further purification. The remaining steps of the synthesis are identical to those of Example 61. 3- (Aminomethyl) benzoyl-D/L-piperidin-4-ylglycine indan-5- amide bis (trifluoroacetate) salt. 'H ΝMR (d 4 MeOH): 8.04 - 7.92 ppm (2 H, m, Ar) ; 7.73 - 7.55 (2 H, m, Ar) ; 7.49 (1 H, s, Ar) ; 7.32 (1 H, d, J = 7.2 Hz, Ar) ; 7.18 (1 H, d, J = 7.2 Hz, Ar) ; 4.68 (1 H, d, J = 9 Hz, CH(Pip)); 4.21 (2 H, s, CH 2 ΝH 2 ) ; 3.54 - 3.40 (2 H, m, piperidine C(2)H and C(6)H); 3.13 - 2.96 (2 H, m, piperidine C(2)H and C(6)H); 2.94 - 2.81 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.41 - 2.23 (1 H, m, piperidine C(4)H); 2.20 - 1.95 (4 H, m, indane C(2)H 2 , piperidine C(3)H and C(4)H); 1.84 - 1.60 (2 H, m, piperidine C(3)H and C(4)H) . HPLC (Luna 2, Gradient 1): rt = 3.08 minutes. LCMS (Luna 2, Gradient 4) : rt = 1.27 minutes, 407 (MH) + . Example 70 2-Amino-5- (aminomethyl) benzoyl-D-phenylglycine indan-5- ylamide bis (trifluoroacetate) salt 2-Amino-5-cyanobenzoic acid A solution of 2-amino-5-bromobenzoic acid (6.9 g, 31.9 mmol) in N-methyl-2-pyrrolidinone (100 mL) was treated with copper cyanide (4.14 g, 46 mmol) and the mixture was heated at 190°C for 4.5 hours before being cooled to room temperature and allowed to stand overnight. The mixture was diluted with water (500 mL) , acidified with 6Ν aqueous HCl (100 mL) and extracted with ethyl acetate (6 x 40 mL) . The organic extracts were dried (MgS0 4 ) and concentrated under reduced pressure to yield the crude nitrile (4.35 g, 84 %) . 2-Amino-5-cyanobenzoyl-D-phenylglycine methyl ester A solution of 2-amino-5-cyanobenzoic acid (1.0 g, 6.17 mmol) in dimethylformamide (50 mL) was treated with l-(3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (1.18 g, 6.17 mmol) and l-hydroxy-7-azabenzotriazole (0.84 g, 6.17 mmol) . After stirring for 10 minutes, D-phenylglycine methyl ester (1.24 g, 6.17 mmol) was added and the resulting solution was stirred overnight at room temperature. The mixture was partitioned between ethyl acetate (50 mL) and water (50 mL) and the organic solution was washed with saturated aqueous citric acid (50 mL) , saturated aqueous NaHC0 3 (50 mL) and water (50 mL) , dried (MgS0 4 ) and concentrated under reduced pressure. The crude product was purified by flash column chromatography (ethyl acetate / hexane, 1:1) to yield 2-amino-5-cyanobenzoyl-D-phenylglycine methyl ester (1.3 g, 68 %) . LC/MS (Luna 2, Gradient 4): rt = 3.28 minutes, 310 (MH) + . 2- (Di-t-butoxycarbonyl) amino-5-cyanobenzoyl-D-phenylglycine methyl ester A solution of 2-amino-5-cyanobenzoyl-D-phenylglycine methyl ester (800 mg, 2.6 mmol) in dimethylformamide (20 mL) was treated with 4-dimethylaminopyridine (30 mg; 0.3 mmol), 1- (3 -dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (500 mg; 2.6 mmol) and di-t-butyldicarbonate (570 mg; 2.6 mmol) . The mixture was stirred overnight at room temperature and then partitioned between ethyl acetate (25 mL) and water (25 mL) . The organic extracts were dried (MgS0 4 ) , concentrated under reduced pressure and the residue was purified by flash column chromatography (ethyl acetate / hexane 3:7) to yield the bis-protected amine (150 mg, 11 %) . 2- (Di-t-butoxycarbonyl) amino-5-cyanobenzoyl-D-phenylglycine The ester (150 mg, 0.29 mmol) was dissolved in tetrahydrofuran (20 mL) and treated with 1 M lithium hydroxide (0.6 mL, 0.6 mmol). The mixture was heated at reflux for 3 hours, cooled to room temperature and concentrated under reduced pressure. The residue was diluted with water (10 mL) , acidified with 5% aqueous HCl (10 mL) and the product extracted into ethyl acetate (25 mL) . The organic extracts were then dried (MgS0 4 ) and concentrated under reduced pressure and the crude acid (110 mg, 75 %) was carried forward without further purification. 2- (Di-t-butoxycarbonyl) amino-5-cyanobenzoyl-D-phenylglycine indan-5-ylamide A solution of the acid (110 mg, 0.20 mmol) in dimethylformamide (10 mL) was treated with l-(3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (30 mg, 0.2 mmol) and l-hydroxy-7-azabenzo-triazole (30 mg, 0.2 mmol) . After stirring for 10 minutes, 5-aminoindane (30 mg, 0.2 mmol) was added and the resulting solution stirred overnight at room temperature. The mixture was partitioned between ethyl acetate (25 mL) and water (25 mL) and the organic solution was washed with saturated aqueous citric acid (25 mL) , saturated aqueous NaHC0 3 (25 mL) and water (25ml) , dried (MgS0 4 ) and concentrated under reduced pressure. The crude product was purified by flash column chromatography (ethyl acetate / hexane, 3:7) to yield 2- (di- t-butoxycarbonyl) amino-5-cyanobenzoyl-D-phenylglycine indan- 5-ylamide as an off-white solid (50 mg, 40 %) . 2-Amino-5- (aminomethyl)benzoyl-D-phenylglycine indan-5- ylamide bis (trifluoroacetate) salt. A solution of the nitrile (50 mg, 0.08 mmol) in methanol (10 mL) and 36% aqueous HCl (0.5ml) was stirred over 10% palladium on carbon (20 mg) under a hydrogen atmosphere for 16 hours. The mixture was filtered and the residue was washed with methanol (10 mL) before concentrating the extracts under reduced pressure. The residue was dissolved in a mixture of trifluoroacetic acid (5 ml) and dichloromethane (5ml) and stirred for one hour. The mixture was concentrated under reduced pressure and the residue purified by preparative HPLC to afford 2- amino-5- (aminomethyl) benzoyl-D-phenylglycine indan-5-ylamide ditrifluoroacetate salt (2 mg, 6 %) . X H NMR (d 4 MeOH): 7.98-7.37 ppm (10 H, m, Ar) ; 7.02 (IH, d, J " = 7.5 Hz, Ar) ; 6.03 (IH, s, CHPh); 3.92 (2 H, s, CH 2 NH 2 ) ; 3.09 (4H, q, J = 7.5Hz, indane C(1)H 2 and C(3)H 2 ); 2.29 (2H, quintet, J = 7.5 Hz, indane C(2)H 2 ). HPLC (Luna 2, Gradient 1): rt = 4.04 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.10 minutes, 398 (MH-NH 3 ) + . Example 71 1- (2-Amino-5- (aminomethyl)benzoyl-D-phenylglycinyl) 4- hydroxypiperidine dihydrochloride salt D-Phenylglycine 4-hydroxypiperidinamide trifluoroacetate salt A solution of 4-hydroxypiperidine (330 mg, 1.4 mmol) in dimethylformamide (10 mL) was treated with 2-(lH- benzotriazole-1-yl) -1,1,3, 3-tetramethyluronium tetrafluoroborate (450 mg; 1.4 mmol) and N- ethyldiisopropylamine (0.74 mL, 4.2 mmol). After stirring for 10 minutes, N-butoxycarbonyl -D-phenylglycine (330 mg, 1.4 mmol) was added and the resulting solution stirred overnight at room temperature. The mixture was partitioned between ethyl acetate (25 mL) and water (25 mL) and the organic solution was washed with saturated aqueous citric acid (25 mL) , saturated aqueous ΝaHC03 (25 mL) and water (25 mL) , dried (MgS04) and concentrated under reduced pressure. The residue was dissolved in dichloromethane (5 mL) and trifluoroacetic acid (5 mL) and stirred for one hour before the solvents were removed under reduced pressure, giving D- phenylglycine-4-hydroxypiperidinamide as its trifluoracetate salt (150 mg, 43 %) . LC/MS (Luna 2, Gradient 4): rt = 2.64 min, 235 (MH) + . 2-amino-5-cyanobenzoyl-D-phenylglycine 4- hydroxypiperidinamide A solution of 2-amino-5-cyanobenzoic acid (170 mg, 1.0 mmol) in dimethylformamide (10 mL) was treated with 1- (3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (210 mg, 1.1 mmol) and l-hydroxy-7-azabenzotriazole (150 mg, 1.1 mmol) . After stirring for 10 minutes, D-phenylglycine 4- hydroxypiperidinamide trifluoroacetate salt (250 mg; 1.1 mmol) was added and the resulting solution stirred overnight at room temperature. The mixture was partitioned between ethyl acetate (25 mL) and water (25 mL) and the organic solution was washed with saturated aqueous citric acid (25 mL) , saturated aqueous NaHC0 3 (25 mL) and water (25 mL) , dried (MgS0 4 ) and concentrated under reduced pressure. The crude product was purified by column chromatography (ethyl acetate) to yield 2-amino-5-cyanobenzoyl-D-phenylglycine 4- hydroxypiperidinamide (90 mg, 23 %) . 1- (2-amino-5- (aminomethyl) benzoyl-D-phenylglycinyl 4- hydroxypiperidine dihydrochloride salt A solution of the nitrile in methanol (10 mL) and 36% hydrochloric acid (0.5 mL) was stirred over 10 % palladium on carbon (20 mg) under an atmosphere of hydrogen for 16 hours. The mixture was filtered and the residue washed with methanol (10 mL) before concentrating the filtrate under reduced pressure. Purification by preparative HPLC afforded 2-amino-5- (aminomethyl) benzoyl-D-phenylglycine 4-hydroxy- piperidinamide dihydrochloride salt (30 mg, 33 %) . X H NMR (d 4 MeOH): 7.84 ppm (1 H, s, Ar) ; 7.61-7.17 (7 H, m, Ar) ; 6.85 (1 H, d, -7 = 8 Hz, Ar) ; 6.12 (1 H, s, CHPh); 4.26 (1 H, m, piperidine C(4)H); 3.99 (2 H, s, CH 2 NH 2 ) ; 3.79 (2 H, m, piperidine C(2)H and C(6)H); 3.42-3.08 (2H, m, piperidine C(2)H and C(6)H); 1.86-0.72 (4H, m, piperidine C(3)H 2 and C(5)H 2 ). HPLC (Luna 2, Gradient 1): rt = 2.49 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.35 minutes, 366 (MH-NH 3 )\ Examples 72 and 73 The compounds of Examples 72 and 73 were prepared by the method described below, but using the appropriate starting materials . Boc D-phenylglycine (251 mg, 1 mmol.) was dissolved in dimethylformamdide (3ml) with HATU [0- (7-azabenzotriazol-l- yl) -1, 1, 3 , 3-tetramethyluronium hexafluorophosphate] (380 mg., 1 mmol.) and diisopropylethylamme (350μl., 2 mmol.). To this mixture was added 4-methylbenzylamine (121mg., 1 mmol.) and diisopropylethylamme (170μl., 1 mmol.). The mixture was stirred overnight. The mixture was then taken up into ethylacetate and washed with water, sodium carbonate solution, water, 10% hydrochloric acid solution and water. The ethylacetate was evaporated without drying and treated immediately with trifluoroacetic acid (TFA) for 30 min. The TFA was then evaporated to dryness and the product triturated with diethylether. Triethylamine (1ml) was added and evaporated to dryness. A solution of 3- hydroxymethylbenzoic acid (76mg, 0.5mmole) in dry dimethylformamide (DMF) was treated with TBTU (161mg., 0.5mmol . ) and diisopropylethylamme (1.5 mmol.). The mixture was then added to the D-phenylglycine-4-methylbenzylamide (0.5mmol.) and stirred overnight. The crude product was dissolved in water/acetonitrile (20ml) , filtered and purified by preparative Hplc to yield pure product. Η nmr (CD 3 CN) 7.75 (IH, m) ; 7.65 (2H, m) ; 7.30 (7H, broad m) ; 6.80 (3H, m) ; 5.40 (IH, s) ; 4.45 (2H,s); 4.10 (2H, m) ; 2.10 (3H, s) . MS TOF 389 (M+l + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 13.51 min. Compounds made by the above method : - Example 72. 3-Aminomethylbenzoyl-D-phenylglycine-4-aminomethylcyclohexyl methylamide 'H nmr (CD 3 CN) 7.95 (2H, m) ; 7.80 (2H, m) ; 7.50 (5H, m) ; 5.65 (IH, s) ; 4.45 (2H, s) ; 3.30 (2H, m) ; 3.00 (2H,m); 2.00-1.00 (10H,m) . MS TOF 409 (M+l + ) . Hplc (Magellan C8, Gradient 3, water/acetonitrile/TFA) rt 12.68 min. Example 73. 3 -Aminomethylbenzoyl-D-phenylglycine-1-adamantylamide X H nmr (CD 3 CN) 7.95 (IH, s) ; 7.85 (2H, d) ; 7.60 (IH, m) ; 7.50 (2H,m); 7.40 (3H,m); 5.65 (IH, s) ; 4.20 (2H, s) ; 2.50-1.50 (15H,m) . MS TOF 418 (M+l + ) . Hplc (Magellan C8 , Gradient 1, water/acetonitrile/TFA) rt 18.36 min. Example 74 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (2- hydroxyphenyl) acetyl-2 , 3 -dihydroindol-6 -amide trifluoroacetate salt. Prepared in a similar manner to Example 35, using (2- hydroxyphenyl) acetic acid. X H NMR (CD 3 CN) : 8.91 ppm (1 H, s, OH), 8.30 (1 H, s, NH) , 7.94 (2 H, br s, Ar) , 7.73 (1 H, d, J = 10 Hz, Ar) , 7.54- 7.06 (12 H, m, Ar & NH) , 7.01 (1 H, d, -7 = 8 Hz, Ar) , 6.74 (2 H, m, Ar) , 5.61 (1 H, d, -7 = 8 Hz, ArCH) , 4.21 (2 H, t, -7 = 8 Hz, dihydroindole C(2)H 2 ), 4.10 (2 H, s, ArCH 2 N) , 3.73 (2H, s, ArCH 2 CO) , 3.10 (2 H, d, J = 8 Hz, dihydroindole C(3)H 2 ). HPLC (Symmetry, Gradient 2): rt = 6.24 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.10 minutes, 535 (MH) + . Example 75 3- (Aminomethyl) benzoyl-D-phenylglycine 1- (3- hydroxyphenyl) acetyl-2, 3 -dihydroindol-6 -amide trifluoroacetate salt. Prepared in a similar manner to Example 35, using (3- hydroxyphenyl) acetic acid. X H NMR (d 4 MeOH): 8.21 ppm (1 H, s, Ar) , 7.71 (2 H, br s, Ar) , 7.50-7.16 (8 H, m, Ar) , 7.05-6.95 (2 H, m, Ar) , 6.64- 6.50 (3 H, m, Ar) , 5.62 (1 H, s, ArCH), 4.09 (2 H, s, ArCH 2 N) , 4.04 (2 H, t, J " = 8 Hz, dihydroindole C(2)H 2 ), 3.68 (2H, s, ArCH 2 C0) , 2.91 (2 H, d, J = 8 Hz, dihydroindole C(3)H 2 ) . HPLC (Symmetry, Gradient 2): rt = 5.95 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.05 minutes, 535 (MH + ) . Example 76 3- (Aminomethyl) benzoyl-D-phenylglycine l-(4- hydroxyphenyl) acetyl-2 , 3 -dihydroindol- 6 -amide trifluoroacetate salt. Prepared in a similar manner to Example 35, using (4- hydroxyphenyl) acetic acid. *H NMR (d 4 MeOH): 8.32 ppm (1 H, s, Ar) , 8.04 (2 H, br s, Ar) , 7.66-7.34 (8 H, m, Ar) , 7.22-7.11 (3 H, m, Ar) , 6.80 (2 H, d, J " = 10 Hz, Ar) , 5.85 (1 H, s, ArCH), 4.21 (2 H, s, ArCH 2 N) , 4.15 (2 H, t, J = 8 Hz, dihydroindole C(2)H 2 ), 3.81 (2 H, s, ArCH 2 CO) , 3.20 (2 H, d, J = 8 Hz, dihydroindole C(3)H 2 ) . HPLC (Symmetry, Gradient 2): rt = 5.97 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.02 minutes, 535 (MH + ) . Example 77 3- (Aminomethyl) benzoyl-D-phenylglycine l-benzyl-3- acetylindol-5-amide trifluoroacetate salt. Prepared in a similar fashion to Example 1, starting from 3-acetyl-5-amino-l-benzylindole, which was prepared as described below. 3-Acetyl-5-nitroindole and 3-acetyl-7-nitroindole Prepared by the method described by Ottoni, Cruz and Kramer in Tetrahedron Letters, 40, 1999, 1117-1120, as a mixture of isomers . 3-Acetyl-l-benzyl-5-nitroindole and 3-acetyl-l-benzyl-7- nitroindole Potassium carbonate (940 mg, 6.8 mmol) was added to a stirred solution of the above indoles (695 mg, 3.4 mmol) in dimethylformamide (30 L) . Benzyl bromide (0.61 mL, 5.1 mmol) was then added dropwise and the mixture left to stir over the weekend. The dimethylformamide was removed under reduced pressure and the residue partitioned between ethyl acetate (30 mL) and water (20 mL) . The ethyl acetate layer was dried (MgS0 4 ) and evaporated to give the benzylamines as a golden oil. 3-Acetyl-5-amino-l-benzylindole and 3-acetyl-7-amino-l- benzylindole A mixture of the indoles (1.0 g, 3.4 mmol), tin(II) chloride dihydrate (3.48 g, 15.4 mmol) and ethanol (20 mL) was heated at reflux, under an atmosphere of nitrogen, for 3 hours. The mixture was cooled and the solvent evaporated to give a brown oil. To this was added water (50 mL) , which was then made basic with 1 N aqueous sodium hydroxide. The aqueous solution was then extracted with ethyl acetate (2 x 30 mL) . The whole biphasic mixture was filtered through celite to remove tin salts, separated and the organic solvent dried (MgS0 4 ) . The solvent was removed under reduced pressure to give a brown oil which was purified by flash chromatography on silica gel (hexane / ethyl acetate; 3:1) to afford, in order of elution, 3 -acetyl-7 -amino-1-benzylindole *H NMR (CDC1 3 ) : 7.67 ppm (1 H, s, indole C(2)H); 7.39 - 7.13 (3 H, m, Ph) ; 7.15 (2 H, m, Ph) ; 7.05 (1 H, t, J " = 6 Hz, indole C(5)H); 6.57 (1 H, d, J = 6.5 Hz, indole C(4)H); 6.41 (1 H, d, J = 6 Hz, indole C(6)H); 5.95 (2 H, br s, NH 2 ) ; 5.27 (2 H, s, PhCH 2 ) ; 2.50 (3 H, s, CH 3 ) and 3-acetyl-5-amino-l-benzylindole 'H NMR (CDC1 3 ) : 8.08 ppm (1 H, d, J = 6 Hz, indole C(7)H); 7.50 (1 H, s, indole C(2)H); 7.31 - 7.22 (3 H, , Ph) ; 7.05 (2 H, m, Ph) ; 6.63 (1 H, dd, J = 6 , 2 Hz, indole C(6)H); 6.45 (1 H, s, indole 4-H) ; 5.25 (2 H, s, PhCH 2 ) ; 3.62 (2 H, br s, NH 2 ) ; 2.5 (3 H, s, CH 3 ) . 3- (Aminomethyl) benzoyl-D-phenylglycine l-benzyl-3- acetylindol-5-amide trifluoroacetate salt. *H NMR (d 4 MeOH): 8.28 ppm (1 H, s, Ar) ; 8.20 (1 H, d, J = 5 Hz, Ar) ; 7.97 (3 H, m, Ar) ; 7.71 - 7.56 (4 H, m, Ar) ; 7.47 - 7.19 (9 H, m, Ar) ; 5.85 (1 H, s, CHPh); 5.45 (2 H, s, CH 2 Ph) ; 4.21 (2 H, CH 2 NH 2 ) ; 2.53 (3 H, s, CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 4.15 minutes. HPLC (Symmetry, Gradient 2): rt = 6.77 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.48 minutes, 531 (MH) + . Example 78 3- (Aminomethyl)benzoyl-D-phenylglycine l-benzyl-3- acetylindol-7-amide trifluoroacetate salt. Prepared in a similar fashion to Example 1, starting from 3- acetyl-7-amino-l-benzylindole, which was prepared as described above . 'H NMR (d 4 MeOH): 8.46 ppm (1 H, s, Ar) ; 8.34 (1 H, d, -7 = 6 Hz, Ar) ; 8.11 - 7.95 (3 H, m, Ar) ; 7.75 - 7.48 (4 H, m, Ar) ; 7.46 - 7.12 (9 H, m, Ar) ; 5.85 (1 H, s, CHPh); 5.48 (2 H, s, CH 2 Ph) ; 4 . 21 ( 2 H , s , CH 2 NH 2 ) ; 2 . 62 ( 3 H , S , CH 3 ) . HPLC (Luna 2, Gradient 1): rt = 4.58 minutes. HPLC (Symmetry, Gradient 2): rt = 6.80 minutes. LC/MS (Luna 2, Gradient 4): rt = 2.80 minutes, 531 (MH) + . Example 79 3- (Aminomethyl) benzoyl-D- (4 -hydroxyphenyl) glycine indan-5- amide trifluoroacetate salt. Prepared in a similar fashion to Example 61, using (4- hydroxyphenyl) glycine and protecting as appropriate. 'H NMR (d 4 MeOH): 8.00 ppm (2 H, s, Ar) ; 7.72 - 7.55 (2 H, m, Ar) ; 7.47 (3 H, t, -7 = 8.6 Hz, Ar) ; 7.31 (1 H, d, J = 7.5 Hz, Ar) ; 7.18 (1 H, d, J = 8 Hz, Ar) ; 6.86 (2 H. d, J = 8.6 Hz, Ar) ; 5.75 (1 H, s, CHPh); 4.23 (2 H, s, CH 2 NH 2 ) ; 2.94 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.12 (2 H, m, indane C(2)H 2 ) . HPLC (Luna 2, Gradient 1): rt = 3.78 minutes. HPLC (Symmetry, Gradient 2): rt = 5.80 minutes. LC/MS (Luna 2, Gradient 4): rt = 1.83 minutes, 416 (MH) + . Example 80 3- (Aminomethyl) benzoyl-D/L-2- (N-formylamino) thiazol-4- yl] glycine 5-indanamide trifluoroacetate salt Prepared using the same method as described for Example 61 from D/L-α- (N^butyloxycarbonyl ) - [2- (N-formylamino) thiaz-4- yl] glycine (synthesised as described below) . Ethyl α-azido- [2- (Ν- formylamino) thiaz-4-yl] acetate A solution of ethyl [2- (N-formylamino) thiaz-4-yl] acetate (1 g, 0.0047 mol) in THF (10 mL) was stirred under argon at - 78°C and potassium bis (trimethylsilyl) amide (2.8 g, 0.014 mol) in THF (10 mL) was added. After stirring for 30 minutes, 2, 4, 6-triisopropylbenzenesulfonyl azide (3.6 g, 0.012 mol) was added as a solid in one portion. After 5 minutes, acetic acid (1.4 mL, 0.018 mol) was added and the mixture warmed to room temperature. The reaction mixture was then partitioned between ethyl acetate (100 mL) and water (100 mL) , separated and the organic layer dried (MgS0 4 ) . Evaporation of the solvent and purification of the residue by silica gel chromotography afforded the azide (0.95 g, 80 %) . X H ΝMR (CDC1 3 ) : 8.78 ppm (1 H, s, ΝHCHO) ; 6.98 (1 H, s, C(5)H); 5.95 (1 H, s, CHΝ 3 ) ; 4.18 (2 H, m, CH 2 CH 3 ) ; 1.20 (3 H, m, CH 2 CH 3 ) . Ethyl α- (N-^utyloxycarbonylamino) - [2- (N-formylamino) thiaz- 4-yl] acetate Di- t butyl dicarbonate (0.9 g, 0.004 mol) and 5% palladium on carbon (catalytic amount) were added to a solution of the azide (0.95 g, 0.0037 mol) in methanol (25 mL) . The mixture was stirred at room temperature under an atmosphere of hydrogen for 8 hours. After this time the mixture was filtered through celite, washing through with methanol (25 mL) . Evaporation of the solvent and purification of the residue by silica gel chromotography afforded the fc butyloxycarbonyl amine as a pale oily solid (1.1 g, 90 %) 'H NMR (CDC1 3 ) : 8.53 ppm (1 H, s, NHCHO); 6.89 (1 H, s, C(5)H) ; 6.18 (1 H, d, J = 8 Hz, NHBoc) ; 5.38 (1 H, d, J " = 8 Hz, CHN) ; 4.06 (2 H, m, CH 2 CH 3 ) ; 1.28 (9 H, s, tBu) ; 1.12 (3 H, m, CH 2 CH 3 ) . D/L-α-N- t butyloxycarbonyl - [2- (N- formylamino) thiaz-4- yl] glycine A solution of the ester (1.1 g, 0.0031 g) in THF (25 mL) was treated with 1 M aqueous LiOH (5 ml, 0.005 mol) and heated at reflux for 1 hour. The solvent was removed under reduced pressure and the residue diluted with water (100 mL) . The pH was reduced to 2 using 5% aqueous HCl and the aqueous phase was extracted with ethyl acetate (3 x 50 mL) . The combined organic extracts were dried (MgS0 4 ) and concentrated under reduced pressure to afford the acid as a white solid (0.8 g, 84 %) . X H ΝMR (d 4 MeOH): 8.38 ppm (1 H, s, ΝHCHO) ; 7.01(1 H, s, C(5)H); 5.21 (1 H, s, CHΝ) ; 1.39 (9 H, s, fc Bu) . 3- (Aminomethyl) benzoyl-D/L- [2- (formylamino) thiazol-4- yl] glycine 5-indanamide trifluoroacetate salt X H NMR (d 4 MeOH): 10.10 ppm (1 H, s, NHCHO); 8.80 (1 H, d, J " = 8 Hz, NH) ; 8.48 (1 H, S, NHCHO); 7.97 (2 H, br s, Ar) ; 7.58 (2 H, m, Ar) ; 7.42 (1 H, s, aminothiazole C(5)H); 7.37 (1 H, d, J " = 7 Hz, indane C(6)H); 7.18 (1 H, s, indane C(4)H); 7.10 (1 H, d, J = 7Hz, indane C(7)H); 5.92 (1 H, m, CHAr); 4.18 (2 H,s, CH 2 NH 2 ) ; 2.83 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.02 (2 H, m, indane C(2)H 2 ) HPLC (Luna 2, gradient 1): rt = 3.71 minutes. LC/MS (Luna 2, gradient 4): rt = 2.05 minutes; 450 (MH) + . Example 81 3 - (Aminomethyl) benzoyl-D/L-2 -aminothiazol-4 -ylglycine-5- indanamide bis (hydrochloride) salt. Prepared from D/L-α-N- t butyloxycarbonyl - [2- (N- formylamino) thiaz-4-yl] glycine and synthesised using the method of Example 80 except that the final deprotection was effected using 3 M aqueous HCl in THF, in order to remove both the ^utyloxycarbonyl and formyl protecting groups. X H ΝMR (d 4 MeOH): 7.87 ppm (2 H, m, Ar) ; 7.51 (1 H, m, Ar) ; 7.48 (1 H, t, J " = 7 Hz, (aminomethyl) benzoyl C(3)H); 7.40 (1 H, s, aminothiazole C(5)H); 7.20 (1 H, d, J " = 8 Hz, indane C(6)H); 7.05 (1 H, d, J = 8 Hz, indane C(7)H); 6.73 (1 H, s, indane C(4)H); 5.78 (1 H, s, CHAr); 4.12 (2 H, s, CH 2 ΝH 2 ) ; 2.79 (4 H, m, indane C(1)H 2 and C(3)H 2 ); 2.00 (2 H, m, indane C(2)H 2 ) . HPLC (Luna 2, gradient 1): rt = 3.21 minutes. LC/MS (Luna 2, gradient 4): rt = 1.78 minutes; 422 (MH) + . The compounds of formula (I) exemplified in the Examples - Part 2 have been found to be inhibitors of tryptase by the method of Tapparelli et al (J. Biol. Chem. 1993,268,4734- 4741) .

Claims: CLAIMS 1. A method of treatment of the human or non-human animal body to combat a condition responsive to a serine protease inhibitor, said method comprising administering to said body an effective amount of a serine protease inhibitor compound of formula (I) (I) where R2 represents a 5 or 6 membered aromatic carbon ring optionally interrupted by a nitrogen, oxygen or sulphur ring atom, optionally being substituted in the 3 and/or 4 position by halo, nitro, thiol, haloalkoxy, hydrazido, alkylhydrazido, amino, cyano, haloalkyl, alkylthio, alkenyl, alkynyl, acylamino, tri or difluoromethoxy, carboxy, acyloxy, MeS0 2 ~ or R # or the substituents at the 3 and 4 positions taken together form a fused ring which is a 5 or 6 membered carbocyclic or heterocyclic ring optionally substituted by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri j , and optionally substituted in the position alpha to the X-X group by amino, hydroxy, halo, alkyl, carboxy, alkoxycarbonyl, cyano, amido, aminoalkyl, hydroxyalkyl, alkoxy or alkylthio with the proviso that R 2 cannot be aminoisoquinolyl; each X independently is a C, N, 0 or S atom or a CO, CRχ a , C(R la )2 or NR la group, at least one X being C, CO, CR la or C(R la ) 2 ; each R a independently represents hydrogen or hydroxyl, alkoxy, alkyl, aminoalkyl, hydroxyalkyl alkoxyalkyl, alkoxycarbonyl, alkylammocarbonyl, alkoxycarbonylamino, acyloxymethoxycarbonyl or alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl; L is an organic linker group containing 1 to 5 backbone atoms selected from C, N, 0 and S, or a branched alkyl or cyclic group; Y (the α-atom) is a nitrogen atom or a CRι D group; Cy is a saturated or unsaturated, mono or poly cyclic, homo or heterocyclic group, optionally substituted by groups R 3a or phenyl optionally substituted by R 3a ; each R 3a independently is Rχ c , amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl, alkylsulphenyl, triazolyl, imidazolyl, tetrazolyl, hydrazido, alkyl imidazolyl, thiazolyl, alkyl thiazolyl, alkyl oxazolyl, oxazolyl, alkylsulphonamido, alkylaminosulphonyl, aminosulphonyl, haloalkoxy and haloalkyl; Lp is a lipophilic organic group; D is a hydrogen bond donor group; and n is 0, 1 or 2 ; and Rx, Rib Ric an( Rij are as defined for Rι a , or a physiologically tolerable salt thereof. 2. A method as claimed in Claim 1, where R2 represents a 5 or 6 membered aromatic carbon ring optionally interrupted by a nitrogen, oxygen or sulphur ring atom, optionally being substituted in the 3 and/or 4 position by halo, nitro, haloalkoxy, amino, cyano, haloalkyl, alkylthio, alkenyl, alkynyl, acylamino, tri or difluoromethoxy, carboxy, acyloxy, MeS0 2 ~ or Ri, or the substituents at the 3 and 4 positions taken together form a fused ring which is a 5 or 6 membered carbocyclic or heterocyclic ring optionally substituted by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij, and optionally substituted in the position alpha to the X-X group by amino, hydroxy, halo, alkyl, carboxy, cyano, amido, aminoalkyl, alkoxy or alkylthio with the proviso that R2 cannot be isoquinolyl; and each Rι a independently represents hydrogen or hydroxyl, alkoxy, alkyl, aminoalkyl, hydroxyalkyl alkoxyalkyl , alkoxycarbonyl , acyloxymethoxycarbonyl or alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl. 3. A method as claimed in Claim 1 or Claim 2, in which n is 0. 4. A method as claimed in any one of Claims 1 to 3 , in which X-X is selected from -CH=CH-, -CONH-, -CONR la -, -NH-CO-, -NH-CH 2 -, -CH 2 -NH-, -CH 2 0-, -OCH 2 -, -COO-, -OC=0- and -CH 2 CH 2 - is CONH. 5. A method as claimed in Claim 4, in which X-X is CONH. 6. A method as claimed in any one of Claims 1 to 5, in which Y is a CRib group and has the conformation that would result from construction from a D-α-aminoacid NH 2 -CRib(Cy) -COOH where the NH 2 represents part of X-X. 7. A method as claimed in any one of Claims 1 to 6, in which Y is CH. 8. A method as claimed in any one of Claims 1 to 7, in which Cy represents an optionally R3 a substituted phenyl, pyridyl, thienyl, thiazolyl, naphthyl, piperidinyl or cycloalkyl group. 9. A method as claimed in Claim 8, in which R 3a is selected from hydrogen, hydroxyl, methoxy, ethoxy, methyl, ethyl, methylaπ-inomethyl, dimethylaminomethyl , hydroxymethyl, carboxy, methoxymethyl, methoxycarbonyl, ethoxycarbonyl , methylaminocarbonyl , dimethylaminocarbonyl , aminomethyl, CONH 2 , CH 2 CONH 2 , aminoacetyl, formylamino, acetylamino, methoxycarbonylamino, ethoxycarbonylamino, t- butoxycarbonylamino, amino, fluoro, chloro, cyano, nitro, thiol, methylthio, methylsulphonyl , ethylsulphonyl, methylsulphenyl, imidazol-4-yl, hydrazido, 2-methylimidazol- 4-yl, methylsulphonylamido, ethylsulphonylamido, methylaminosulphonyl, ethylaminosulphonyl , aminosulphonyl, trifluoromethoxy and trifluoromethyl . 10. A method as claimed in any one of Claims 1 to 9, in which Cy is phenyl, 4-aminophenyl, 4-amidophenyl, 4- (N- methyl) amidophenyl, 4- (N,N-dimethyl) amidophenyl, 2- chlorophenyl, 2-methylphenyl, 2-fluorophenyl, 3- fluorophenyl, 4-fluorophenyl, 4-hydroxyphenyl , 2- methoxyphenyl , 4-methoxyphenyl, 3-aminomethylphenyl, 4- aminomethylphenyl , 2-hydroxymethylphenyl, 3- hydroxymethylphenyl , 4-hydroxymethylphenyl, 4-carboxyphenyl, 3-ethylsulphonylaminophenyl, thien-2-yl, thien-3-yl, thiazol-4-yl, thiazol-5-yl, 2-methylthiazol-4-yl , 2- aminothiazol-4-yl, 2-formylaminothiazol-4-yl, 2- aminothiazol-5-yl, 2-formylaminothiazol-5-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, 4-aminopyrid-3-yl , 4-aminopyrid-4- yl, piperidin-4-yl, l-methylpiperidin-4-yl, cyclohexyl or naphth-1-yl . 11. A method as claimed in any one of Claims 1 to 10, in which L represents CO, CH2NH, CONRι d (CH 2 ) ra , (CH 2 ) m N(Rι d )CO(CH 2 ) m - (CH 2 ) m+2 . CO(CH 2 ) ra , (CH 2 ) m CO, (CH 2 ) m 0C=0, (CH 2 ) m O, CH=CH(CH 2 ) m , S0 2 , S0 2 NRι d , S0 2 (CH 2 ) m , (CH2) m Sθ 2 or (CH 2 ) m S0 2 NR l d (where each m is independently 0 or 1 and Rι d is as defined for Rι a ) . 12. A method as claimed in Claim 11, in which L is CO, CONH, CH 2 NHCO and CONHCH 2 . 13. A method as claimed in any one of Claims 1 to 12, in which R represents: (i) phenyl optionally being substituted in the 3 and/or 4 position by halo, nitro, thiol, haloalkoxy, hydrazido, alkylhydrazido, amino, cyano, haloalkyl, alkylthio, alkenyl, alkynyl, acylamino, tri or difluoromethoxy, carboxy, acyloxy, MeS0 2 - or Ri, and optionally substituted at the 6 position by amino, hydroxy, halo, alkyl, carboxy, alkoxycarbonyl, cyano, amido, aminoalkyl, alkoxy or alkylthio; (ii) naphth-2-yl optionally substituted at the 6 or 7 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri j and optionally substituted at the 3 position by amino, hydroxy, halo, alkyl, carboxy, cyano, amido, aminoalkyl, alkoxy or alkylthio; (iii) isoquinolin-7-yl, indol-5-yl, indol-6-yl, indazol-5-yl, indazol-6-yl, benzothiazol-6-yl or benzisoxazol-5-yl optionally substituted at the 3 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij; (iv) benzimidazol-5-yl or benzothiazol-6-yl optionally substituted at the 2 position by amino; (v) thien-2-yl or thien-3-yl optionally substituted at the 4 or 5 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri ; (vi) 3 , 4-methylenedioxyphenyl, 2 , 3 -dihydroindol-6-yl , 3 , 3-dichloro-2-oxo-indol-6-yl or 1-methyl-3 -aminoindazol-5- yi ; (vii) benzothiazol-2-yl, imidazo [1, 2-a] pyrimidin-2-yl or tetrahydroimidazo [1, 2-a] pyrimidin-2-yl; (viii) pyrazol-2-yl optionally substituted at the 5 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri ; (ix) pyrid-2-yl optionally substituted at the 5 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri; (x) pyrid-3-yl optionally substituted at the 6 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Ri; (xi) benzofur-2-yl optionally substituted at the 3 position by amino, hydroxy, halo, alkyl, carboxy, cyano, amido, aminoalkyl, alkoxy or alkylthio and at the 5 or 6 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or ij; (xii) indol-2-yl optionally substituted on the indole nitrogen atom by alkyl and optionally substituted at the 5 or 6 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij; (xiii) indol-6-yl substituted at the 5 position by amino, hydroxy, halo (such as fluoro or chloro), alkyl, carboxy, alkoxycarbonyl, cyano, amido, aminoalkyl, alkoxy or alkylthio and optionally substituted at the 3 position by halo (such as chloro), haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij; or (xiv) benzo [b] thiophen-2-yl optionally substituted at the 3 position by amino, hydroxy, halo, alkyl, carboxy, cyano, amido, aminoalkyl, alkoxy or alkylthio and at the 5 or 6 position by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or Rij. 14. A method as claimed in Claim 13, in which R2 represents: (i) phenyl optionally being substituted in the 3 and/or 4 position by fluoro, chloro, bromo, iodo, nitro, difluoromethoxy, trifluoromethoxy, amino, cyano, trifluoromethyl, methylthio, vinyl, carboxy, acetoxy, MeSθ 2 ~ , hydroxy, methoxy, ethoxy, methyl, methoxycarbonyl, methylamino, ethylamino or amido, and optionally substituted at the 6 position by amino, hydroxy, fluoro, methoxycarbonyl, cyano or aminomethyl (preferably phenyl substituted in the 4 position by chloro, amino, vinyl, methylamino, methyl or methoxy, optionally at the 3 position with amino or hydroxy, and optionally at the 6 position with amino or hydroxy) ; (ii) naphth-2-yl optionally substituted at the 6, position by hydroxy and optionally substituted at the 3 position by amino or hydroxy; (iii) isoquinolin-7-yl, indol-5-yl, indol-6-yl, indazol-5-yl , indazol-6-yl, benzothiazol-6-yl or benzisoxazol-5-yl optionally substituted at the 3 position by chloro, bromo, amino, methyl or methoxy; (iv) benzimidazol-5-yl or benzothiazol-6-yl optionally substituted at the 2 position by amino; (v) thien-2-yl or thien-3-yl optionally substituted at the 4 or 5 position by methylthio, methyl or acetyl ; (vi) 3 , 4-methylenedioxyphenyl, 2 , 3 -dihydroindol-6-yl , 3 , 3-dichloro-2-oxo-indol-6-yl or l-methyl-3-aminoindazol-5- yl; (vii) benzothiazol-2-yl, imidazo [1, 2-a] pyrimidin-2-yl or tetrahydroimidazo [1, 2-a] pyrimidin-2-yl; (viii) pyrazol-2-yl substituted at the 5 position by methyl ; (ix) pyrid-2-yl optionally substituted at the 6 position by chloro; (x) pyrid-3-yl optionally substituted at the 4 position by chloro; (xi) benzofur-2-yl optionally substituted at the 3 position by chloro, methyl or methoxy, at the 5 or 6 position by methyl and at the 6 position by methoxy; (xii) indol-2-yl optionally substituted on the indole nitrogen atom by methyl and optionally substituted at the 5 or 6 position by fluoro, chloro, bromo, methyl or methoxy; (xiii) indol-6-yl substituted at the 5 position by chloro, fluoro or hydroxy and optionally substituted at the 3 position by chloro or methyl; or (xiv) benzo [b] thiophen-2-yl optionally substituted at the 3 position by fluoro, chloro or methyl, and optionally substituted at the 5 or 6 position by fluoro, chloro, methyl, hydroxy, or methoxy. 15. A method as claimed in any on of Claim 14, in which R 2 represents indol-6-yl optionally substituted at the 3 position by chloro, bromo, methyl or methoxy or indol- 6-yl substituted at the 5 position by chloro, fluoro or hydroxy and optionally substituted at the 3 position by chloro or methyl . 16. A method as claimed in any one of Claims 1 to 15, in which Lp is an alkyl, alkenyl, carbocyclic or heterocyclic group, or a combination of two or more such groups linked by a spiro linkage or a single or double bond or by C=0, O, S, SO, S0 2 , CONRι e , NRι e -CO-, NR ie linkage (where Rι e is as defined for Rι a ) , optionally substituted by one or more oxo or R 3 groups in which R 3 is alkylammocarbonyl , alkoxycarbonylamino, N- alkylaminoalkanoyl , N-alkanoylaminoalkanoyl, C- hydroxyaminoalkanoyl or as defined for R 3a . 17. A method as claimed in Claim 16, in which R 3 is selected from hydrogen, hydroxyl, methoxy, ethoxy, methyl, ethyl, propyl, 2-propyl, butyl, 2- butyl, t-butyl, pentyl, 2-pentyl or 3 -pentyl, isopropylaminomethyl , dimethylaminomethyl , diethylaminomethyl, dimethylaminoethyl , acetyl, hydroxymethyl, hydroxyethyl , carboxy, methoxymethyl, methoxycarbonyl , ethoxycarbonyl , methylaminocarbonyl , dimethylaminocarbonyl , aminomethyl , aminocarbonyl , methylamino, dimethylamino, ethylamino, formylamino, acetylamino, amino, fluoro, chloro, cyano, nitro, thiol, methylthio, methylsulphonyl, ethylsulphonyl, isopropylsulphonyl, methylsulphenyl, 1, 2 , 4-triazol-2-yl, l,2,4-triazol-4-yl, 1, 2 , 3-triazol-4-yl , 1, 3-imidazol-l-yl or 1, 3-imidazol-4-yl, tetrazol-1-yl, tetrazol-5-yl ; methylsulphonamido, ethylsulphonamido, propylsulphonamido, methylaminosulphonyl , ethylaminosulphonyl , propylaminosulphonyl, aminosulphonyl, trifluoromethoxy, trifluoromethyl and trichloromethyl . 18. A method as claimed in any one of Claims 1 to 17 in which said condition is a condition responsive to a Factor Xa inhibitor and Ri is not an unsubstituted aminoalkyl group . 19. A method as claimed in Claim 18, in which Lp is a group of formula: X a X b (L a )s-(G)r(L b )u-Rιo in which: r is 1 or 2; one of X a and Xtø is N and the other is CH or N provided that when r is 1, X a and X D are not both N; s, t and u are each 0 or 1; L a and L D are each independently selected from a single bond, C=0, O and NRι e , in which Rι e is hydrogen or (1- 6C) alkyl; G is (1-6C) alkanediyl; and R lO is (1-6C) alkyl, (3-6C) cycloalkyl which is unsubstituted or substituted by (1-6C) alkyl, indanyl, pyridyl, tetrahydropyranyl, tetrahydrothiopyranyl , phenyl which is unsubstituted or substituted by one or two R 3 groups, pyrrolinyl, or a group of formula in which v is 1, 2 or 3 ; one of X c and X d is N and the other is CH or N, provided that when v is 1, X c and X d are not both N; and Rn is hydrogen, (1-6C) alkyl or when X d is CH, hydroxy (1-6C) alkyl; provided that when t is 0, the sum of s and u is 1; when Xtø is N, L a is a bond or C=0; when X c is N, Lj j is a bond or C=0; when X]-, and X c are both N, t is 1; and when (L a ) s - (G) t - (L b ) represents an alkyl group and X b and X c both represent N, the alkyl group contains at least two chain carbon atoms . 20. A method as claimed in Claim 19, in which either X a is N and L is CO or CH 2 CO, or X a is CH and L is CONH, C0NHCH 2 or CH 2 NHCO. 21. A method as claimed in Claim 18, in which -L-Lp(D) n is: (i) in which q is 1 or 2; (a) Q is a direct bond; and Rq is piperidin-4-yl which may bear a Cι_3alkyl substituent at the 1-position; or Rg is NR a R b i n which each of R a and Rj-, independently is hydrogen or Cι_3alkyl; or one of R a and R D is hydrogen or methyl and the other of R a and Rj-, is -CH2-R C or-CH2~Rd in which R c is pyridyl or phenyl (which phenyl may bear a fluoro, chloro, methyl, CONH 2 , S0 2 NH 2 , methylaminosulphonyl , dimethylammosulphonyl , methylsulphonylamino, methoxy or methylsulphonyl substituent) and in which R d is isopropyl or cyclopentyl, or NR a R D is pyrrolidino, piperidino, morpholino, piperazino, or tetrahydro-1, 4-diazepino in which a pyrrolidino or piperidino may be a 3 , 4-didehydro deriviative and in which a pyrrolidino, piperidino, piperazino, or tetrahydro-1, 4-diazepino may bear a methyl group at the 4-position; (b) Q is -0- or -NH- ; and Rg is R c which is defined as above ; or (c) Q is methylene; and Rg is NR a Rb which is defined as above ; (ii) in which R r is -(CH 2 ) C -R C , -CHR e Rf, -CH -CHR e Rf, or Rg in which c is 1 or 2 and R c is defined as above; each of R e and Rf independently is hydrogen or Cι_3alkyl; or CHR e Rf is cyclopentyl (which may bear a methyl, ethyl or hydroxymethyl substituent at the 3- or 4-position), cyclohexyl (which may bear a methyl, ethyl or hydroxymethyl substituent at the 3- or 4-position) , tetrahydropyran-4-yl , tetrahydrothiopyran-4- yl , pyrrolidin-3-yl (which may bear a 1-methyl substituent), piperidin-4-yl (which may bear a 1-methyl substituent) , or indan-2-yl; and Rg is 2 -methylsulphonylphenyl which may bear a 4-fluoro substituent or R g is λ 6 -l,l- dioxobenzo [b] thiophen-7-yl; (iii) in which q is 1 or 2; s is 0 or 1; and R s is -(CH 2 ) C -R C , -CHR e Rf, or -CH 2 "CHR e Rf each of which is defined as above; (iv) in which R^ is piperidin-4-yl , piperidin-3-yl or pyrrolindin-3-yl, any of which may bear a C1-- 3 alkyl substituent at the 1-position (preferably methyl, ethyl or, more preferably, 2-propyl) ; or R^ is phenyl (which phenyl may bear a fluoro, chloro, C 1 -- 4 alkyl, methoxy or methylsulphonyl substituent) ; or (v) in which Het is a divalent 5 membered heteroaromatic group containing 1, 2 or 3 heteroatoms selected from 0, N and S and having the two ring atoms at which it is connected separated by one ring atom; h is 0 or 1; and Rh is phenyl which may bear one or more R 3 substituents . 22. A method as claimed in Claim 21, in which (i) q is 2, and in (a) R q is piperidin-4-yl which may bear a (1-3C) alkyl substituent at the 1-position; and in (b) R c is pyrid-2-yl, pyrid-3-yl or pyrid-4-yl) ; (ii) c is 2 and R c is pyrid-2-yl, pyrid-3-yl or pyrid-4-yl; (iii) s is 1; (iv) R t is piperidin-4-yl which may bear a methyl, ethyl or 2-propyl substituent at the 1-position; and (v) Rft is phenyl which may bear one or more R 3 substituents independently selected from, for an ortho or a para substituent: C 1 -- 5 alkyl, fluoro, chloro, difluoromethyl, trifluoromethyl, methoxy, dimethylamino, methylsulphonyl , and Cι_ 2 acyl, and for a meta substituent: fluoro, chloro and methyl . 23. A method as claimed in Claim 18, in which -L-Lp(D) n is in which R^ is phenyl which may bear an ortho and/or a para substituent independently selected from, for an ortho: methyl, fluoro, chloro, methylsulphonyl and acetyl, and for a para substituent: methyl, fluoro, chloro, methoxy and dimethylamino; Zi is S, Z 2 is CH, h is 0; or Zi is NH, Z 2 is N, h is 1. 24. A method as claimed in Claim 18, in which Lp is selected from where % represents H, OMe, Sθ 2 Me, F, cyano, amido, amino, NO 2 , Cl or OH; and R is hydrogen or (1-6C) alkyl. 25. A method as claimed in Claim 18, in which Lp represents wherein X 2 is halo, hydrogen, amino, nitro or CONH 2 . 26. A method as claimed in any one of Claims 1 to 17, in which said condition is a condition responsive to a tryptase inhibitor and R 2 is substituted in the 3 and/or 4 position by Ri in which Ri is an unsubstituted aminoalkyl group. 27. A method as claimed in Claim 26, in which R 2 group is of the formula in which R 5 is amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen, and R 6a is hydrogen or methyl. 28. A method as claimed in Claim 27, in which R2 is 3- aminomethylpheny1 or 3 -aminomethyl -6 -aminophenyl . 29. A method as claimed in Claim 28, in which R 2 is 3- aminomethylphenyl . 30. A method as claimed in any one of Claims 26 to 29, in which: (i) L represents CO and Lp represents (ii) L represents CONH and Lp represents in which X is CH or N; (iii) L represents CONH and Lp represents in which R 3 is alkylammocarbonyl , N-alkylaminoalkanoyl, N- alkanoylaminoalkanonyl, C-hydroxyaminoalkanoyl, hydrogen, alkoxy, alkyl, aminoalkyl, aminocarbonyl, hydroxyalkyl, alkoxyalkyl , alkoxycarbonyl , acyloxymethoxycarbonyl , alkylamino, amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl, alkylsulphenyl, triazolyl, imidazolyl, tetrazolyl, hydrazido, alkyl imidazolyl, thiazolyl, alkyl thiazolyl, alkyl oxazolyl, oxazolyl, alkylsulphonamido, alkylaminosulphonyl, aminosulphonyl, haloalkoxy or haloalkyl ; or (iv) L represents CONH and Lp represents in which R 3x represents R 3 or a group of formula - (CO) p -(G 1 ) -R j in which p is 0 or 1; G x represents (1-3C) alkanediyl or, when p is 1, a bond; and R j represents a carbocyclic or heterocyclic group, optionally substituted by R 3 . 31. A method as claimed in Claim 30, in which: in (i) R 3 represents hydrogen, hydroxyl or alkylammocarbonyl ; in (ii) R 3 is hydrogen, amino, hydroxy, alkyl or aminoalkyl; in (iii) the phenyl group is unsubstituted or substituted by one or two R 3 groups; and in (iv) the 2 , 3 -dihydroindolyl group is a 2 , 3-dihydroindol- 5-yl or 2, 3 -dihydro-6-yl group of the formula in which: when R 3 is a substituent on the 1-position of a 2, 3-dihydroindolyl group, it represents alkylammocarbonyl ; N-alkylaminoalkanoyl; N-alkanoylaminoalkanonyl ; C- hydroxyaminoalkanoyl ; hydrogen; alkyl; alkanoyl; alkoxycarbonyl ; acyloxymethoxycarbonyl ; aminoalkyl ; aminoalkanoyl ; hydroxyalkyl ; hydroxyalkanoyl ; alkoxyalkyl ; or alkanoylamino; and when R 3 is a substituent on a phenyl, thiazolyl, imidazolyl or pyridyl group, it is hydrogen, amino, alkyl or aminoalkyl. 32. Use of a compound as defined in any one of Claims 1 to 31 for the manufacture of a medicament for the treatment of a condition as defined in any one of Claims 1 to 31. 33. A pharmaceutical composition for use in the treatment of a condition as defined in any one of Claims 1 to 31, which comprises a compound as defined in any one of Claims 1 to 31.

Inventors: CAMP NICHOLAS PAUL, HARRISON MARTIN JAMES, JONES STUART DONALD, LIEBESCHUETZ JOHN WALTER, LIVELY SARAH ELIZABETH, LYONS AMANDA JANE, MASTERS JOHN JOSEPH, MORGAN PHILLIP JOHN, MURRAY CHRISTOPHER WILLIAM, RICHARDS SIMON JAMES, RIMMER ANDREW DAVID, WASZKOWYCZ BOHDAN, WILEY MICHAEL JOHN, WYLIE WILLIAM ALEXANDER, YOUNG STEPHEN CLINTON, CAMP, NICHOLAS, PAUL, HARRISON, MARTIN, JAMES, JONES, STUART, DONALD, LIEBESCHUETZ, JOHN, WALTER, LIVELY, SARAH, ELIZABETH, LYONS, AMANDA, JANE, MASTERS, JOHN, JOSEPH, MORGAN, PHILLIP, JOHN, MURRAY, CHRISTOPHER, WILLIAM, RICHARDS, SIMON, JAMES, RIMMER, ANDREW, DAVID, WASZKOWYCZ, BOHDAN, WILEY, MICHAEL, JOHN, WYLIE, WILLIAM ALEXANDER, YOUNG, STEPHEN, CLINTON
Applicants: CAMP NICHOLAS PAUL, HARRISON MARTIN JAMES, JONES STUART DONALD, LIEBESCHUETZ JOHN WALTER, LILLY CO ELI, LIVELY SARAH ELIZABETH, LYONS AMANDA JANE, MASTERS JOHN JOSEPH, MORGAN PHILLIP JOHN, MURRAY CHRISTOPHER WILLIAM, PROTHERICS MOLECULAR DESIGN LT, RICHARDS SIMON JAMES, RIMMER ANDREW DAVID, WASZKOWYCZ BOHDAN, WILEY MICHAEL JOHN, WYLIE WILLIAM ALEXANDER, YOUNG STEPHEN CLINTON, CAMP, NICHOLAS, PAUL, ELI LILLY AND COMPANY, HARRISON, MARTIN, JAMES, JONES, STUART, DONALD, LIEBESCHUETZ, JOHN, WALTER, LIVELY, SARAH, ELIZABETH, LYONS, AMANDA, JANE, MASTERS, JOHN, JOSEPH, MORGAN, PHILLIP, JOHN, MURRAY, CHRISTOPHER, WILLIAM, PROTHERICS MOLECULAR DESIGN LIMITED, RICHARDS, SIMON, JAMES, RIMMER, ANDREW, DAVID, WASZKOWYCZ, BOHDAN, WILEY, MICHAEL, JOHN, WYLIE, WILLIAM ALEXANDER, YOUNG, STEPHEN, CLINTON
Application year: 2000
Main classification: C07D211
IPC codes: C07C237, C07C255, C07D209, C07D211, C07D213, C07D215, C07D217, C07D231, C07D235, C07D241, C07D277, C07D295, C07D317, C07D333, C07D401, C07D403, C07D405, C07D413, C07D417, C07D487