METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA

Abstract: This invention relates, in part, to newly identifid methods of using quinoline antibiotics, particulrly a gemifloxacin compound against certain bactera, particularly pathogenic bacteria

Description: METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against bacteria, particularly bacterial pathogens. BACKGROUND OF THE INVENTION Quinolones have been shown to be effective to varying degrees against a range of bacterial pathogens. However, as diseases caused by these pathogens are on the rise, there exists a need for antimicrobial compounds that are more potent than the present group of quinolones. Gemifloxacin mesylate (SB-265805) is a novel fluoroquinolone useful as a potent antibacterial agent. Gemifloxacin compounds are described in detail in patent application PCT/KR98/00051 published as WO 98/42705. Patent application EP 688772 discloses novel quinoline(naphthyridine)carboxylic acid derivatives, including anhydrous (R,S)-7-(3- aminomethyl-4-methoxyiminopyrrolidin- 1 -yl)- 1 -cyclopropyl-6-fluoro-4-oxo- 1 ,4-dihydro- 1 ,8- naphthyridine-3-carboxylic acid of formula I. I PCT/KR98/00051 discloses (R,S)-7-(3-aminomethyl-4-^n-methoxyimino-pyrrolidin- 1 -yl)- 1 -cyclopropyl-6-fluoro-4-oxo- 1 ,4-dihydro- 1 ,8-naphthyridine-3-carboxy lie acid methanesulfonate and hydrates thereof including the sesquihydrate. Provided herein is a significant discovery made using a gemifloxacin compound against certain bacteria, such as, but not limited to MTB, enteropathogenic bacteria, certain Gram positive bacteria, respiratory tract pathogens, genital tract pathogenic bacteria, anaerobic pathogenic bacteria, uropathogenic bacteria, nosocomial Gram negative bacteria, and enteropathogenic bacteria. Disclosed herein are demonstrations that activity of a gemifloxacin compound of the invention was superior to a number of quinolones as described in more detail herein. Gemifloxacin compounds are, therefore, valuable compounds for the treatment of clinical indications caused by a range of bacteria, including those resistant to usual oral therapy, thereby filling an unmet medical need. SUMMARY OF THE INVENTION An object of the invention is a method for modulating metabolism of MTB pathogenic bacteria comprising the step of contacting MTB pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said MTB pathogenic bacteria is selected from the group consisting of: MTB strain H37Rv, RMTB strains and SMTB strains. Also provided by the invention is a method of treating or preventing a bacterial infection by MTB pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with MTB pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: MTB strain H37Rv, RMTB strains and SMTB strains. An object of the invention is a method for modulating metabolism of enteropathogenic pathogenic bacteria comprising the step of contacting enteropathogenic pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said enteropathogenic pathogenic bacteria is selected from the group consisting of: Salmonella spp. (e.g., S. hadar, S. virchow, S. tshiongwe, and S. newport) , Hafnia alvei, Yersinia enterocolitica, Shigella spp., Aeromonas spp. and Campylobacter jejuni. Also provided by the invention is a method of treating or preventing a bacterial infection by enteropathogenic pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with enteropathogenic pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: Salmonella spp. (e.g., S. hadar, S. virchow, S. tshiongwe, and S. newport) , Hafnia alvei, Yersinia enterocolitica, Shigella spp., Aeromonas spp. and Campylobacter jejuni. An object of the invention is a method for modulating metabolism of Gram positive pathogenic bacteria comprising the step of contacting Gram positive pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said Gram positive pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, Staphylococcus aureus and Enterococcus faecalis. Also provided by the invention is a method of treating or preventing a bacterial infection by Gram positive pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with Gram positive pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, Staphylococcus aureus and Enterococcus faecalis. An object of the invention is a method for modulating metabolism of respiratory tract pathogenic bacteria comprising the step of contacting respiratory tract pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said respiratory tract pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Klebsiella pneumoniae. Also provided by the invention is a method of treating or preventing a bacterial infection by respiratory tract pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with respiratory tract pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Klebsiella pneumoniae. An object of the invention is a method for modulating metabolism of respiratory tract pathogenic bacteria comprising the step of contacting respiratory tract pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said respiratory tract pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae and Haemophilus influenzae. Also provided by the invention is a method of treating or preventing a bacterial infection by respiratory tract pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with respiratory tract pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: Streptococcus pneumoniae and Haemophilus influenzae. An object of the invention is a method for modulating metabolism of respiratory tract pathogenic bacteria comprising the step of contacting respiratory tract pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said respiratory tract pathogenic bacteria is selected from the group consisting of: Haemophilus influenzae, Staphylococcus aureus, Streptococcus pneumoniae, E. coli, P. aeruginosa and Moraxella catarrhalis. Also provided by the invention is a method of treating or preventing a bacterial infection by respiratory tract pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with respiratory tract pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: Haemophilus influenzae, Staphylococcus aureus, Streptococcus pneumoniae, E. coli, P. aeruginosa and Moraxella catarrhalis. An object of the invention is a method for modulating metabolism of respiratory or urinary tract pathogenic bacteria comprising the step of contacting respiratory or urinary tract pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said respiratory or urinary tract pathogenic bacteria is selected from the group consisting of: Staphylococcus aureus (including oxacillin-susceptible, oxacillin-resistant, and quinolone-resistant strains), Staphylococcus epidermidis (including oxacillin-susceptible, oxacillin-resistant strains), Streptococcus pneumoniae (including qauinolone-resistant, amoxicillin-susceptible, amoxicillin-resistant, erythromycin- susceptible and erythromycin-resistant strains), Streptococcus pyrogenes, Enterococcus faecalis (including ciprofloxacin-susceptible and ciprofloxacin-resistant strains), Enterococcus faecium (including vanA and vanB vancomycin-resistant strains), Enterococcus gallinarum (including vanCl), Escherichia coli (including ciprofloxacin-susceptible and ciprofloxacin-resistant strains), Citrobacter freundii, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter cloacae, Salmonella spp., Shigella spp., Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Serratia marcescens, Pseudomonas aeruginosa, Bukolderia cepacia, Stenotrophomonas maltophilia, Acintobacter calcoaceticus, Haemophilus influenzae, Moraxella catarrhalis, and Neisseria gonorrhoeae. Also provided by the invention is a method of treating or preventing a bacterial infection by respiratory or urinary tract pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with respiratory or urinary tract pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: Staphylococcus aureus (including oxacillin-susceptible, oxacillin- resistant, and quinolone-resistant strains), Staphylococcus epidermidis (including oxacillin- susceptible, oxacillin-resistant strains), Streptococcus pneumoniae (including qauinolone- resistant, amoxicillin-susceptible, amoxicillin-resistant, erythromycin-susceptible and erythromycin-resistant strains), Streptococcus pyrogenes, Enterococcus faecalis (including ciprofloxacin-susceptible and ciprofloxacin-resistant strains), Enterococcus faecium (including vanA and vanB vancomycin-resistant strains), Enterococcus gallinarum (including vanCl), Escherichia coli (including ciprofloxacin-susceptible and ciprofloxacin-resistant strains), Citrobacter freundii, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter cloacae, Salmonella spp., Shigella spp., Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Serratia marcescens, Pseudomonas aeruginosa, Bukolderia cepacia, Stenotrophomonas maltophilia, Acintobacter calcoaceticus, Haemophilus influenzae, Moraxella catarrhalis, and Neisseria gonorrhoeae. An object of the invention is a method for modulating metabolism of anaerobic pathogenic bacteria comprising the step of contacting anaerobic pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said anaerobic pathogenic bacteria is selected from the group consisting of: Gram positive and Gram negative anaerobic bacteria, including Peptostreptococcus anaerobius, Peptostreptococcus asaccharolyticus,Peptostreptococcus indolicus, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus prevotii, Staphylococcus saccharolyticus, Atopobium parvulus, Streptococcus constellatus, Streptococcus intermedius, Gemella morbillorum, Clostridium clostridioforme, Clostridium difficile, Clostridium peifringens, Clostridium septicum, Clostridium sordellii, Clostridium ramosum, Propionibacterium acnes, Propionibacterium granulosum, Eubacterium lentum, Actinomyces odontolyticus, Bifidobacterium adolescentis, Bifidobacterium bifldum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium pseudolongum, Lactobacillus, Lactobacillus brevis subsp. Brevis, Lactobacillus casei subsp. casei, Lactobacillus fermentum, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus salivarius subsp. salivarius, bacteroides fragilis, Bacteroides vulgatus, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides eggerthii, Bacteroides ureolyticus, Campylobacter gracilis, Sutterella wadsworthensis, Prevotella bivia, Prevotella buccae, Prevotella corporis, Prevotella heparinolytica, Prevotella intermedia, Prevotella melaninogenica, Prevotella oralis, Prevotella oris, Porphyromonas asaccharolytica, Porphylomonas gingivalis, Fusobacterium nucleatum, Fusobacterium varium, Fusobacterium necrophorum, Bilophilla wadsworthia, Desulfomonas pigra, Capnocytophaga ochracea, Veillonella parvula, Veillonella dispar, Peptostreptococcus anaerobius, Peptostreptococcus asccharolyticus, Peptostreptococcus magnus, Peptostreptococcus micros, Propionibacterium acnes, Actinomyces spp., Clostridium difficile, Clostridium perfringens, Bacteroides distasonis, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, B. fragilis group organisms (B. caccae; B. eggerthii, B. ovatus), Imipenem-resistant B. fragilis group organisms (B. distasonis, B. fragilis), Prevotella bivia, Prevotella intermedia, Other Prevotella spp., Porphyromonas spp., Fusobacterium nucleatum, and Veillonella spp.. Also provided by the invention is a method of treating or preventing a bacterial infection by anaerobic pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with anaerobic pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: Gram positive and Gram negative anaerobic bacteria, including Peptostreptococcus anaerobius, Peptostreptococcus asaccharolyticus,Peptostreptococcus indolicus, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus prevotii, Staphylococcus saccharolyticus, Atopobium parvulus, Streptococcus constellatus, Streptococcus intermedius, Gemella morbillorum, Clostridium clostήdioforme, Clostridium difficile, Clostridium perfringens, Clostridium septicum, Clostridium sordellii, Clostridium ramosum, Propionibacterium acnes, Propionibacterium granulosum, Eubacterium lentum, Actinomyces odontolyticus, Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium pseudolongum, Lactobacillus, Lactobacillus brevis subsp. Brevis, Lactobacillus casei subsp. casei, Lactobacillus fermentum, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus salivarius subsp. salivarius, bacteroides fragilis, Bacteroides vulgatus, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides eggerthii, Bacteroides ureolyticus, Campylobacter gracilis, Sutterella wadsworthensis, Prevotella bivia, Prevotella buccae, Prevotella corporis, Prevotella heparinolytica, Prevotella intermedia, Prevotella melaninogenica, Prevotella oralis, Prevotella oris, Porphyromonas asaccharolytica, Porphylomonas gingivalis, Fusobacterium nucleatum, Fusobacterium varium, Fusobacterium necrophorum, Bilophilla wadsworthia, Desulfomonas pigra, Capnocytophaga ochracea, Veillonella parvula, Veillonella dispar, Peptostreptococcus anaerobius, Peptostreptococcus asccharolyticus, Peptostreptococcus magnus, Peptostreptococcus micros, Propionibacterium acnes, Actinomyces spp., Clostridium difficile, Clostridium perfringens, Bacteroides distasonis, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, B. fragilis group organisms (B. caccae; B. eggerthii, B. ovatus), Imipenem-resistant B. fragilis group organisms (B. distasonis, B. fragilis), Prevotella bivia, Prevotella intermedia, Other Prevotella spp., Porphyromonas spp., Fusobacterium nucleatum, and Veillonella spp. An object of the invention is a method for modulating metabolism of uropathogenic pathogenic bacteria comprising the step of contacting uropathogenic pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said uropathogenic pathogenic bacteria is selected from the group consisting of: K. pneumoniae, P. mirabilis, E. coli, P. aeruginosa, S. aureus, and E. faecalis. Also provided by the invention is a method of treating or preventing a bacterial infection by uropathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with uropathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: K. pneumoniae, P. mirabilis, E. coli, P. aeruginosa, S. aureus, and E. faecalis. An object of the invention is a method for modulating metabolism of nosocomial Gram negative pathogenic bacteria comprising the step of contacting nosocomial Gram negative pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said nosocomial Gram negative pathogenic bacteria is selected from the group consisting of: Acinetobacter spp., Enterobacter spp., Proteus mirabilis, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa. Also provided by the invention is a method of treating or preventing a bacterial infection by nosocomial Gram negative pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with nosocomial Gram negative pathogenic bacteria. Further prefeπed methods are provided by the invention wherein said bacteria is selected from the group consisting of: Acinetobacter spp., Enterobacter spp., Proteus mirabilis, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa. An object of the invention is a method for modulating metabolism of Gram positive pathogenic bacteria comprising the step of contacting Gram positive pathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said Gram positive pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus (including Methicillin-susceptible and Methicillin- resistant strains), and Staphylococcus epidermidis (including Methicillin-susceptible and Methicillin- resistant strains). Also provided by the invention is a method of treating or preventing a bacterial infection by Gram positive pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with Gram positive pathogenic bacteria. Further preferred methods are provided by the invention wherein said bacteria is selected from the group consisting of: Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus (including Methicillin-susceptible and Methicillin-resistant strains), and Staphylococcus epidermidis (including Methicillin-susceptible and Methicillin- resistant strains). An object of the invention is a method for modulating metabolism of enteropathogenic bacteria comprising the step of contacting enteropathogenic bacteria with an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound, or an antibacterially effective derivative thereof. A further object of the invention is a method wherein said enteropathogenic bacteria is selected from the group consisting of: Salmonella spp. (including S. enteritidis, S. typhimurium, S. virchow, S. tshiongwe, S. newport, S. ohio, S. hadar, and S. georgia), Hafnia alvei, Yersinia enterocolitica, Shigella spp. (including 5. sonnei, S.flexneri, and 5. boydiϊ), Aeromonas spp. (including A. hydrophila and A. sobria), and Campylobacter jejuni. Also provided by the invention is a method of treating or preventing a bacterial infection by enteropathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with enteropathogenic bacteria. Further prefened methods are provided by the invention wherein said bacteria is selected from the group consisting of: Salmonella spp. (including S. enteritidis, S. typhimurium, S. virchow, S. tshiongwe, S. newport, S. ohio, S. hadar, and S. georgia), Hafnia alvei, Yersinia enterocolitica, Shigella spp. (including S. sonnei, S.flexneri, and S. boydiϊ), Aeromonas spp. (including A. hydrophila and A. sobria), and Campylobacter jejuni. A preferred method is provided wherein said modulating metabolism is inhibiting growth of said bacteria or killing said bacteria. A further preferred method is provided wherein said contacting said bacteria comprises the further step of introducing said composition into a mammal, particularly a human. Still further prefened methods comprise a gemifloxacin compound selected from the group consisting of gemifloxacin mesylate, gemifloxacin mesylate hydrate, gemifloxacin mesylate hemihydrate and gemifloxacin mesylate sesquihydrate. Various changes and modifications within the spirit and scope of the disclosed invention will become readily apparent to those skilled in the art from reading the following descriptions and from reading the other parts of the present disclosure. DESCRIPTION OF THE INVENTION The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against MTB. As used herein "gemifloxacin compound(s)" means a compound having antibacterial activity described in patent application PCT/KR98/00051 published as WO 98/42705 on 1 October 1998, or patent application EP 688772, and these applications are incoφorated herein by reference. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various MTB pathogens. An objective of these analyses was to determine the MIC range, MIC 50 and MIC 90 of six fluoroquinolones: ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin and gemifloxacin. Tuberculosis caused by multi-drug-resistant strains of Mycobacterium tuberculosis (MTB) poses a therapeutic challenge in terms of the selection of appropriate antimicrobial agents. Although quinolones may have a useful role in treating these infections, comparative in vitro data with classic and new agents of this class are scarce. An objective of this study was to evaluate the in vitro activity of six fluoroquinolones against clinical isolates of MTB with different levels of susceptibility to first-line antituberculous drugs. Tuberculosis caused by multi-drug-resistant strains of Mycobacterium tuberculosis (MTB) presents a therapeutic challenge to physicians selecting antimicrobial agents. Quinolones can have a useful role in treating these infections, but comparative in vitro data with classic and new agents of this class are scarce. A total of 82 MTB strains were tested by the proportions method using NCCLS methodology (M24-T, 1995) against the quinolones ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin and the novel compound gemifloxacin (SB-265805). The concentration range of antimicrobials assayed was 0.5-4 μg/ml and the MTB strain H37Rv was used for quality control. Thirty-seven strains were resistant (RMTB) to at least one first-line antituberculous drug, while the rest were fully susceptible (SMTB). The MIC range, MIC 50 and MIC 90 (μg/ml) were obtained for the agents tested. MICs of 82 MTB strains were evaluated using the proportions method according to NCCLS criteria (M24-T, 1995). The fluoroquinolones investigated were ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin and gemifloxacin (SB-265805). The antimicrobial concentrations assayed were 0.5^*1 μg/ml. MTB strain H37Rv was used for quality control. All MTB strains had been previously tested with first-line antituberculous drugs (except pyrazinamide) by the agar proportions method. Thirty-seven strains were resistant (RMTB) to at least one first-line antituberculous drug, while the rest were fully susceptible (SMTB). Levofloxacin (MIC 90 1 μg/ml) demonstrates the greatest activity against the strains of MTB tested, although ciprofloxacin, ofloxacin and grepafloxacin also demonstrate good activity with MIC 90 S of 2 μg/ml. Trovafloxacin and gemifloxacin show lower in vitro activity against MTB than the other quinolones. In general, quinolone activity is higher in SMTB strains than in RMTB strains, with a twofold difference in MIC 90 . The invention provides a method for modulating metabolism of MTB pathogenic bacteria. Skilled artisans can readily choose MTB pathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by MTB pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with MTB pathogenic bacteria. While a preferred object of the invention provides a method wherein said MTB pathogenic bacteria is selected from the group consisting of: MTB strain H37Rv, RMTB strains and SMTB strains. Other MTB pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against enteropathogenic bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against 288 clinical isolates obtained from 1996 to 1999. An objective of these analyses was to determine the MICs of gemifloxacin, trovafloxacin, grepafloxacin, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin and nalidixic acid by the agar dilution method (NCCLS, 4th ed., M7-A4, Villanova, PA (1997)) on Mueller-Hinton agar supplemented with 5% sheep blood for Campylobacter isolates. Gemifloxacin was compared to trovafloxacin, grepafloxacin, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin and nalidixic acid. Isolates were incubated aerobically at 35°C for 24 h, except for Campylobacter strains, which were incubated microaerophilically for 48 h. MIC 50 s are equal to MIC 90 S except in the case of Salmonella spp. and C. jejuni, where the MICs differ by 1-2 dilutions. Non-susceptibility rates for nalidixic acid range from 0% (H. alvei, Shigella spp.) to 4.50% (Y. enterocolitica), 6.25% (Aeromonas spp.), 27.00% (Salmonella spp.) and 69.24% (C. jejuni). One per cent of Salmonella spp. were non-susceptible to grepafloxacin. Gemifloxacin and ciprofloxacin are the most active compounds tested. A high rate of quinolone-resistant C. jejuni was detected. Gemifloxacin possesses a broad spectrum of antibacterial activity that includes both Gram negative and Gram positive pathogens. Classic oral antimicrobials used against enteropathogenic bacterial isolates have recently demonstrated poor in vitro activity, emphasizing the need to test new quinolones against these organisms. A total of 288 enteropathogenic bacterial isolates from patients with acute gastroenteritis were studied, including 106 Salmonella spp., 32 Hafnia alvei, 22 Yersinia enterocolitica, 21 Shigella spp., 16 Aeromonas spp. and 91 Campylobacter jejuni. The microrganisms were isolated during the period 1996-99 and strains were stored in skimmed milk at -80°C until studied. The eight quinolones tested were gemifloxacin, trovafloxacin, grepafloxacin, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin and nalidixic acid. MICs were determined by an agar dilution method (NCCLS, 4th ed., M7-A4, Villanova, PA (1997)) on Mueller-Hinton agar supplemented with 5% sheep blood for C. jejuni isolates. The plates were incubated aerobically at 35°C for 24 h, except for C. jejuni, where a microaerophilic atmosphere was obtained using Campy Pack and incubation was for 48 h. All organisms were tested with an inoculum of approximately 10 CFU/spot. MICs were defined as the lowest antimicrobial concentration at which there was no visible bacterial growth. Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 27853 were used as controls. The antimicrobial susceptibility breakpoints used to define the percentage of susceptible isolates are as follows: gemifloxacin, trovafloxacin, grepafloxacin and ciprofloxacin 1 μg/ml; ofloxacin and levofloxacin 2 μg/ml; norfloxacin 4 μg/ml; and nalidixic acid 16 μg/ml. Table 1 shows the activity of gemifloxacin and seven other quinolones against 288 enteropathogenic bacterial strains. Table 2 shows the MICs of all quinolones tested against six Salmonella spp. (S. hadar, n = 2; S. virchow, n = 2; S. tshiongwe, n = 1; and S. newport, n = 1) in which MICs for ciprofloxacin were >0.25 μg/ml, which is considered by some authors to be clinically significant resistance. The activity of gemifloxacin against the six groups of enteropathogenic bacterial strains herein was measured. All H. alvei and Shigella spp. isolates are susceptible to all quinolones studied at the breakpoint stated. Of 106 Salmonella spp. studied, 27% of isolates are not susceptible to nalidixic acid and 1% are not susceptible to grepafloxacin. All strains are susceptible to the other six quinolones. Among the isolates of Y. enterocolitica and Aeromonas spp. studied, 100% are susceptible to the quinolones tested, except for nalidixic acid, where the proportions of non- susceptible strains are 4.5% and 6.3%, respectively. A high incidence of quinolone-resistant C. jejuni is detected, with only 31.9% of strains being susceptible to all the antimicrobials tested. MIC 50 s are equal to MIC 90 s, except for Salmonella spp. and C. jejuni where the MICs differ by 1- 2 dilutions. Against six Salmonella spp. with ciprofloxacin MICs >0.25 μg/ml (considered by some authors to be clinically significant resistance), MICs of gemifloxacin are 1-4 dilutions lower than those of the other fluoroquinolones studied. By weight, gemifloxacin and ciprofloxacin are the most active compounds tested in this study. Table 1. The In Vitro activity of gemifloxacin and seven other quinolones against Enteropathogenic Bacterial Strains. Isolates and antimicrobials MIC (μg/ml) Range 50% 90% % Susceptible Salmonella spp. (n = 106) Gemifloxacin <0.015-0.25 0.03 0.12 100 Trovafloxacin <0.015-1 0.06 0.25 100 Grepafloxacin 0.03-2 0.06 0.25 99 Ciprofloxacin <0.015-1 0.03 0.12 100 Ofloxacin 0.06-2 0.12 0.5 100 Norfloxacin 0.06-4 0.06 0.5 100 Levofloxacin 0.06-1 0.06 0.25 100 Nalidixic acid 2->128 4 >128 73 Haf ia alvei (n = 32) Gemifloxacin ≤O.015-0.06 0.03 0.03 100 Trovafloxacin 0.03-0.12 0.06 0.06 100 Grepafloxacin ≤O.015-0.06 0.03 0.06 100 Isolates and antimicrobials MIC (μg/ml) Range 50% 90% % Susceptible Ciprofloxacin <0.015 <0.015 <0.015 100 Ofloxacin 0.03 0.03 0.03 100 Norfloxacin ≤O.015-0.03 0.03 0.03 100 Levofloxacin ≤O.015-0.03 0.03 0.03 100 Nalidixic acid 1-2 2 2 100 Yersinia enterocolitica (n = 22) Gemifloxacin <0.015-0.12 0.03 0.03 100 Trovafloxacin ≤O.015-0.25 0.06 0.06 100 Grepafloxacin ≤O.015-0.25 0.03 0.03 100 Ciprofloxacin ≤O.015-0.25 0.03 0.03 100 Ofloxacin 0.03-0.5 0.12 0.12 100 Norfloxacin 0.06-0.5 0.06 0.06 100 Levofloxacin 0.03-0.5 0.06 0.06 100 Nalidixic acid 0.5->128 2 2 95.5 Shigella spp. (n = 21) Gemifloxacin <0.015 <0.015 <0.015 100 Trovafloxacin <0.015 <0.015 <0.015 100 Grepafloxacin ≤O.015-0.03 <0.015 0.03 100 Ciprofloxacin <0.015 <0.015 <0.015 100 Ofloxacin ≤O.015-0.06 0.03 0.06 100 Norfloxacin 0.03-0.06 0.06 0.06 100 Levofloxacin ≤O.015-0.03 0.03 0.03 100 Nalidixic acid 1-2 1 2 100 Aeromonas spp. (n = 16) Gemifloxacin <0.015-0.12 <0.015 0.03 100 Trovafloxacin ≤O.015-0.25 <0.015 0.03 100 Grepafloxacin <0.015-0.12 0.03 0.06 100 Ciprofloxacin <0.015-0.06 <0.015 <0.015 100 Ofloxacin <0.015-0.12 <0.015 0.03 100 Norfloxacin <0.015-0.12 <0.015 0.03 100 Levofloxacin <0.015-0.06 <0.015 <0.015 100 Nalidixic acid 0.06->128 0.12 0.25 93.75 Campylobacter jejuni (n = 91) Gemifloxacin 0.03-128 32 128 31.86 Trovafloxacin ≤O.015-32 8 8 31.86 Grepafloxacin 0.03-128 32 64 31.86 Ciprofloxacin 0.06-128 16 64 31.86 Ofloxacin 0.06->128 16 32 31.86 Norfloxacin 0.12->128 128 >128 31.86 Levofloxacin 0.06-128 8 32 31.86 Nalidixic acid 2->128 >128 >128 30.76 Table 2. MICs of Quinolones Tested Against Six Salmonella spp. in Which MICs for Ciprofloxacin were >0.25 μg/ml Antimicrobial MIC (μg/ml) S. virchow S. hadar S. tshiongwe S. newport (n = 2) (n = 2) (n = l) (n = l) Gemifloxacin 0.12 0.25 0.25 0.25 Trovafloxacin 0.25 0.5 1 0.5 Grepafloxacin 0.25 1 2 1 Ciprofloxacin 0.25 0.5 1 0.5 Ofloxacin 0.5 2 2 2 Norfloxacin 0.5 4 4 2 Levofloxacin 0.25 1 1 1 Nalidixic acid >128 >128 >128 >128 The invention provides a method for modulating metabolism of enteropathogenic bacteria. Skilled artisans can readily choose enteropathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by enteropathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with enteropathogenic bacteria. While a prefened object of the invention provides a method wherein said enteropathogenic bacteria is selected from the group consisting of: Salmonella spp. (e.g., S. hadar, S. virchow, S. tshiongwe, and S. newport) , Hafnia alvei, Yersinia enterocolitica, Shigella spp., Aeromonas spp. and Campylobacter jejuni. Other enteropathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against Gram positive bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various Gram positive cocci pathogens. An objective of these analyses was to determine the MICs of gemifloxacin and comparator quinolones. Gemifloxacin was compared to other quinolones ciprofloxacin, ofloxacin, levofloxacin and trovafloxacin (CD? = ciprofloxacin, OFL = ofloxacin, LEV = levofloxacin, TRO = trovafloxacin, GEM = gemifloxacin) and with that of other commonly used antimicrobials (penicillin, amoxycillin/clavulanate, cefuroxime, ceftriaxone, co-trimoxazole and azithromycin). The organisms studied were strains of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, Staphylococcus aureus and Enterococcus faecalis isolated during 1998-99 in three Medical Centers in Buenos Aires, Argentina. The macrodilution agar method was used following the NCCLS guidelines. From 90 S. pneumoniae isolates studied, 76.7% were penicillin susceptible, 18.9% were penicillin intermediate and 4.4% were penicillin resistant. A total of 18.5% of H. influenzae isolates were β-lactamase positive and 17% of S. aureus isolates were methicillin resistant. Certain results of this study indicate that gemifloxacin has enhanced activity against Gram positive bacteria compared with the other quinolones tested. Gemifloxacin has enhanced activity against Gram positive organisms, particularly S. pneumoniae, including strains of pneumococci resistant to other quinolones. This study compares the in vitro activity of gemifloxacin with that of other quinolones and commonly used antimicrobials. A total of 41 1 fresh clinical bacterial isolates obtained during 1998-99 and considered to have clinical significance were investigated. The following antimicrobials were tested: gemifloxacin, ofloxacin, levofloxacin, trovafloxacin, ciprofloxacin, penicillin, co-trimoxazole, azithromycin, amoxycillin/clavulanate, cefuroxime and ceftriaxone. MICs were determined using the agar dilution method following NCCLS recommended procedures. The nitrocefin method was used to determine β-lactamase production in H. influenzae and M. catarrhalis. The methicillin resistance of 5. aureus was evaluated using the Kirby-Bauer disk diffusion method with oxacillin disks. The distribution of the organisms studied is given in Table 3. The antimicrobial activity of gemifloxacin and comparator quinolones is shown in Table 4. The activity of quinolones against S. pneumoniae is given in Tables 5 and 6 and that against S. aureus in Table 7. Gemifloxacin has excellent in vitro activity against Gram positive cocci. Gemifloxacin has enhanced activity against S. pneumoniae, with MIC 90 s of 0.03 μg/ml for penicillin-susceptible and penicillin-resistant strains. Gemifloxacin maintains excellent activity against ciprofloxacin- resistant strains (MIC >4 μg/ml) of S. pneumoniae. Gemifloxacin demonstrated excellent activity against S. aureus, with MIC 90 s of 0.03 μg/ml for methicillin-susceptible strains. Gemifloxacin shows excellent in vitro activity against all isolates of //, influenzae (MIC 90 0.008 μg/ml) and M. catarrhalis (MIC 90 0.008 μg/ml). Table 3. Distribution of the Organisms Studied Microrganism n % Streptococcus pneumoniae 90 100 Penicillin susceptible 69 76.7 Penicillin intermediate 17 18.9 Microrganism n % Penicillin resistant 4 4.4 Haemophilus influenzae 65 100 β-Lactamase positive 12 18.5 Ciprofloxacin resistant 1 1.5 Moraxella catarrhalis 59 100 β-Lactamase positive 57 96.6 Streptococcus pyogenes 69 100 Macrolide resistant 4 5.8 Staphylococcus aureus 80 100 Methicillin resistant 14 17.5 Enterococcus faecalis 48 100 Table 4. In Vitro Activity of Gemifloxacin and Comparator Quinolones Microorganism Antimicrobial MIC (μg/ml) Range MICgo Streptococcus pneumoniae (n - 90) Gemifloxacin <0.004-0.125 0.03 Ciprofloxacin 0.5-16 2 Ofloxacin 1-16 2 Levofloxacin 0.25-4 1 Trovafloxacin 0.016-1 0.25 Haemophilus influenzae (n = 65) Gemifloxacin <0.004-0.125 0.008 Ciprofloxacin <0.004-2 0.03 Ofloxacin 0.008-0.25 0.06 Levofloxacin <0.004-0.25 0.016 Trovafloxacin <0.004-0.5 0.03 Moraxella catarrhalis (n = 59) Gemifloxacin <0.004-0.016 0.008 Ciprofloxacin 0.008-0.03 0.03 Ofloxacin 0.06-0.125 0.125 Levofloxacin <0.004-0.03 0.03 Trovafloxacin <0.004-0.03 0.016 Streptococcus pyogenes (n = 69) Gemifloxacin <0.004-0.125 0.03 Ciprofloxacin 0.125-4 1 Microorganism Antimicrobial MIC (μg/ml) Range MlCrø Ofloxacin 0.5-4 2 Levofloxacin 0.25-2 0.5 Trovafloxacin 0.06-1 0.125 Staphylococcus aureus (n = 80) Gemifloxacin <0.004-2 1 Ciprofloxacin 0.125->32 16 Ofloxacin 0.125->32 8 Levofloxacin 0.06-8 4 Trovafloxacin <0.004-8 2 Enterococcus faecalis (n = 48) Gemifloxacin 0.008-8 2 Ciprofloxacin 0.5->32 >32 Ofloxacin 0.125->32 >32 Levofloxacin 0.125->32 >32 Trovafloxacin <0.004-16 8 Table 5. Comparative In Vitro Activity of Antimicrobials Against S. pneumoniae Strains Antimicrobial MIC 90 (μg/ml) Penicillin Penicillin Penicillin resistant susceptible intermediate (n = 4) (n = 69) (n = 17) Amoxycillin/clavulanate 0.016 1 1 Cefuroxime 0.03 4 4 Ceftriaxone 0.016 1 1 Co-trimoxazole 8 8 >16 Azithromycin 0.06 1 0.06 Ciprofloxacin 2 2 2 Ofloxacin 2 2 1 Levofloxacin 1 1 1 Trovafloxacin 0.25 0.25 0.125 Table 6. Comparative In Vitro Activity of Quinolones Against Ciprofloxacin-resistant 5. pneumoniae Strains (in the Absence of NCCLS Breakpoint Criteria MICs >4 μg/ml Were Considered to be Resistant) MIC (μg/ml) Strain 1 Strain 2 Strain 3 Strain 4 Ciprofloxacin 4 4 16 16 Ofloxacin 2 2 16 8 Levofloxacin 1 1 4 2 Trovafloxacin 0.25 0.025 1 1 Gemifloxacin 0.03 0.06 0.125 0.06 Table 7. Comparative In Vitro Activity of Fluoroquinolones in S. aureus Strains MIC 90 (μg/ml) Resistance (%) Methicillin Methicillin Methicillin Methicillin susceptible resistant susceptible resistant (n = 66) (π = 14) (n = 66) (n = 14) Ciprofloxacin 0.5 >32 0 100 Ofloxacin 0.5 16 0 100 Levofloxacin 0.25 8 0 100 Trovafloxacin 0.06 4 0 7 Gemifloxacin 0.03 2 0 0 The invention provides a method for modulating metabolism of Gram positive pathogenic bacteria. Skilled artisans can readily choose Gram positive pathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by Gram positive pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with Gram positive pathogenic bacteria. While a prefened object of the invention provides a method wherein said Gram positive pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, Staphylococcus aureus and Enterococcus faecalis. Other Gram positive pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against respiratory tract pathogenic bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various respiratory tract pathogens. An objective of these analyses was to determine the MIC 90 s of gemifloxacin and comparator drugs against strains of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Klebsiella pneumoniae. Gemifloxacin was compared to ciprofloxacin, clinafloxacin, levofloxacin, moxifloxacin, sparfloxacin, trovafloxacin and cefuroxime against 450 respiratory tract pathogens (GEM = gemifloxacin, CIP = ciprofloxacin, CLI = clinafloxacin, LEV = levofloxacin, MOX = moxifloxacin, SPA = sparfloxacin, TRO = trovafloxacin, CEF = cefuroxime). Using NCCLS reference broth microdilution methodology, 100 strains oi Streptococcus pneumoniae (18 penicilin resistant, 16 penicillin intermediate, 20 penicillin susceptible, 30 erythromycin resistant, 16 multi-drug resistant), 100 Streptococcus pyogenes (60 erythromycin resistant, 20 multi-drug resistant, 20 fully susceptible), 100 Haemophilus influenzae (20 β- lactamase positive), 50 Moraxella catarrhalis (37 β-lactamase positive), 50 Staphylococcus aureus (20 β-lactamase positive, 10 erythromycin resistant) and 50 Klebsiella pneumoniae (20 extended spectrum β-lactamase positive) were tested. The MIC 90 s of gemifloxacin and comparator drugs are listed in Tables 8-13. Gemifloxacin is 4-64 times more potent than that of all comparator agents against S. pneumoniae. Gemifloxacin activity against 5. pyogenes is 2-32 fold higher than that of the other fluoroquinolones tested. Gemifloxacin and clinafloxacin has superior activity than other test drugs against H. influenzae and M. catarrhalis. Against 5. aureus and K. pneumoniae, the new fluoroquinolone display the lowest MIC 90 These results indicate a role for gemifloxacin in the treatment of community-acquired respiratory tract infections. Bacterial resistance to antimicrobials, if widespread, can translate into failure of treatment for any type of infection. The appearance of new drug is therefore met with great expectations, particularly if the novel molecule displays both a relevant spectrum of antibacterial activity and the ability to overcome resistance. The worldwide increase in the number of respiratory tract pathogens resistant to antimicrobials documented in the past few years has made the development of more potent drugs to treat these microrganisms crucial. Gemifloxacin possesses a spectrum bactericidal activity against Gram positive and Gram negative, aerobic and anaerobic species, and is being investigated in phase III clinical trials (Paek, et al., 38th ICAAC, Abstract F-092 (1998); Kelly, et al., 38th ICAAC, Abstract F-087 (1998)). As the incidence of bacterial resistance is dictated by patterns of antimicrobial usage and this is known to vary widely in different geographic settings, it is important to explore the efficacy of any newly developed compound to establish its usefulness in various environmental niches. To this end, gemifloxacin has been tested against 450 recently isolated respiratory tract pathogens. The following microrganisms were studied: 100 Streptococcus pneumoniae (18 penicillin- resistant, 16 penicillin-intermediate, 20 penicillin-susceptible, 30 erythromycin-resistant and 16 multi-drug-resistant strains), 100 Streptococcus pyogenes (60 erythromycin-resistant, 20 multi- drug-resistant and 20 fully susceptible strains), 100 Haemophilus influenzae (20 β-lactamase- producing strains), 50 Moraxella catarrhalis (37 β-lactamase-producing strains), 50 Staphylococcus aureus (20 β-lactamase producers and 10 erythromycin-resistant strains) and 50 Klebsiella pneumoniae (20 extended-spectrum, β-lactamase-producing strains). The activity of gemifloxacin was compared with that of ciprofloxacin, clinafloxacin, levofloxacin, moxifloxacin, sparfloxacin, trovafloxacin and cefuroxime using NCCLS reference broth microdilution methodology (NCCLS, 4th ed., pages M7-A3 and M100-S8, Wayne, PA (1998)). The in vitro susceptibilities of gemifloxacin and comparator drugs against 100 S. pneumoniae strains are reported in Table 8. Gemifloxacin emerged as the most potent antimicrobial among those studied (MIC 90 0.03 μg/ml). Clinafloxacin and trovafloxacin had the same MIC 90 (0.12 μg/ml), while moxifloxacin, sparfloxacin and levofloxacin had MIC 90 s of 0.25, 0.5 and 1 μg/ml, respectively. Ciprofloxacin and cefuroxime displayed the highest MIC 90 (2 μg/ml). When strains of S. pneumoniae are considered according to their level of penicillin susceptibility, gemifloxacin is again the most potent drug tested against penicillin-intermediate and penicillin-resistant microrganisms. Gemifloxacin and cefuroxime have comparable activity against penicillin-susceptible S. pneumoniae (MIC 90 S 0.03 and 0.015 μg/ml, respectively). The same was true when macrolide- resistant pneumococci were considered: gemifloxacin has the lowest MIC 90 . MICs of gemifloxacin and the other drugs against 100 S. pyogenes strains are listed in Table 9. Gemifloxacin (MIC 90 0.03 μg/ml) and cefuroxime (MIC 90 0.015 μg/ml) had the lowest MIC 90 s, followed by clinafloxacin (0.06 μg/ml), moxifloxacin and trovafloxacin (0.25 μg/ml), levofloxacin and ciprofloxacin (0.5 μg/ml) and sparfloxacin (1 μg/ml). Against 5. pyogenes, gemifloxacin and cefuroxime emerged as the most effective drugs, inespective of the mechanism of macrolide resistance the bacteria possessed. Table 10 reports the activities of the drugs against 100 H. influenzae strains. Gemifloxacin and clinafloxacin were the most potent drugs tested (MIC 90 <0.00075 μg/ml). Ciprofloxacin, sparfloxacin and levofloxacin possessed good activity (MIC 90 0.03 μg/ml). Trovafloxacin and moxifloxacin had a MIC 90 of 0.06 μg/ml. Cefuroxime was the least potent drug (MIC 90 1 μg/ml). Table 8. MICs of Gemifloxacin and Comparative Drugs Against 100 Strains of S. pneumoniae icrorganism and antimicrobial MIC (μg/ml) Range MIC50 MICgo Streptococcus pneumoniae (n = 100) Gemifloxacin <0.0075-0.03 0.015 0.03 Ciprofloxacin 0.06-4 1 2 Trovafloxacin 0.03-0.25 0.12 0.12 Sparfloxacin 0.12-1 0.5 0.5 Clinafloxacin 0.03-0.25 0.06 0.12 Moxifloxacin 0.03-0.25 0.12 0.25 Levofloxacin 0.25-2 1 1 Cefuroxime <0.0075-8 0.03 2 Streptococcus pneumoniae (penicillin susceptible) (n = 20) Microrganism and antimicrobial MIC (μg/ml) Range MICso MIC 90 Gemifloxacin <0.0075-0.03 0.015 0.03 Ciprofloxacin 0.06-2 1 2 Trovafloxacin 0.06-0.12 0.12 0.12 Sparfloxacin 0.12-0.5 0.25 0.25 Clinafloxacin 0.015-0.12 0.06 0.12 Moxifloxacin 0.06-0.25 0.25 0.25 Levofloxacin 0.25-1 1 1 Cefuroxime <0.0075-0.015 0.015 0.015 Streptococcus pneumoniae (penicillin resistant) (n = 18) Gemifloxacin <0.0075-0.06 <0.0075 0.06 Ciprofloxacin 0.5-8 0.5 8 Trovafloxacin 0.06-0.25 0.12 0.12 Sparfloxacin 0.25-1 0.5 1 Clinafloxacin 0.06-0.25 0.12 0.25 Moxifloxacin 0.03-0.12 0.06 0.12 Levofloxacin 0.5-2 0.5 1 Cefuroxime 2-8 2 8 Streptococcus pneumoniae (penicillin intermediate) (n = 16) Gemifloxacin <0.0075-0.03 0.015 0.015 Ciprofloxacin 0.5-2 1 1 Trovafloxacin 0.06-0.12 0.12 0.12 Sparfloxacin 0.5-1 0.5 0.5 Clinafloxacin 0.06-0.12 0.12 0.12 Moxifloxacin 0.06 0.06 0.06 Levofloxacin 0.5 - 1 1 1 Cefuroxime 0.12-8 2 2 Streptococcus pneumoniae (multi-drug resistant) * (n = 16) Gemifloxacin <0.0075-0.03 0.015 0.03 Ciprofloxacin 0.5-4 1 2 Trovafloxacin 0.06-0.12 0.06 0.12 Sparfloxacin 0.12-0.5 0.5 0.5 Clinafloxacin 0.06-0.12 0.12 0.12 Moxifloxacin 0.06-0.25 0.06 0.12 Levofloxacin 0.5-1 1 1 Cefuroxime 0.015-0.25 0.03 0.03 Streptococcus pneumoniae (erythromycin resistant MLS B phenotype) (n = 16) Gemifloxacin <0.0075-0.03 0.03 0.015 Ciprofloxacin 1-2 1 2 Trovafloxacin 0.06-0.12 0.06 0.12 Sparfloxacin 0.12-0.5 0.25 0.25 Clinafloxacin 0.03-0.12 0.06 0.12 Moxifloxacin 0.12-0.25 0.25 0.25 Levofloxacin 0.5-2 1 1 Cefuroxime 0.015-0.5 0.015 0.03 Streptococcus pneumoniae (erythromycin resistant M phenotype) (n = 16) Gemifloxacin 0.015-0.05 0.015 0.03 Ciprofloxacin 1-2 1 2 Trovafloxacin 0.06-0.12 0.06 0.12 Sparfloxacin 0.25 0.25 0.25 Clinafloxacin 0.03-0.12 0.06 0.12 Moxifloxacin 0.12-0.25 0.25 0.25 Levofloxacin 1-2 1 1 Cefuroxime <0.0075-0.12 0.015 0.12 * Multi-drug resistant = simultaneously resistant to erythromycin, co-trimoxazole, tetracycline and chloramphenicol Table 9. MICs of Gemifloxacin and Comparative Drugs Against 100 Strains of 5. pyogenes Microrganism and antimicrobial MIC (μg/ml) Range MIC 50 MICgo Streptococcus pyogenes (n = 100) Gemifloxacin <0.00375-0.06 0.015 0.03 Ciprofloxacin 0.12-2 0.25 0.5 Trovafloxacin 0.03-1 0.12 0.25 Microrganism and antimicrobial MIC (μg/ml) Range MIC 5 o MIC 90 Sparfloxacin 0.06-1 0.5 1 Clinafloxacin 0.015-0.12 0.06 0.06 Moxifloxacin 0.06-0.5 0.12 0.25 Levofloxacin 0.06-2 0.5 0.5 Cefuroxime <0.00375-0.015 0.0075 0.015 Streptococcus pyogenes (erythromycin resistant C phenotype [MLS B ]) (n = 20) Gemifloxacin <0.00375-0.03 0.015 0.015 Ciprofloxacin 0.25-0.5 0.25 0.25 Trovafloxacin 0.03-0.12 0.06 0.12 Sparfloxacin 0.25-1 0.25 0.25 Clinafloxacin 0.03-0.12 0.06 0.12 Moxifloxacin 0.12-0.25 0.25 0.25 Levofloxacin 0.25-1 0.25 0.25 Cefuroxime <0.00375 - 0.015 <0.00375 0.015 Streptococcus pyogenes (erythromycin resistant M phenotype) (n = 20) Gemifloxacin <0.00375-0.03 0.015 0.015 Ciprofloxacin 0.12-0.5 0.25 0.5 Trovafloxacin 0.06-0.5 0.12 0.12 Sparfloxacin 0.25-1 0.5 0.5 Clinafloxacin 0.015-0.06 0.03 0.06 Moxifloxacin 0.06-0.25 0.12 0.25 Levofloxacin 0.06-1 0.5 0.5 Cefuroxime <0.00375-0.015 <0.00375 0.015 Streptococcus pyogenes (erythromycin resistant I phenotype [MLS B ]) (n = 20) Gemifloxacin ≤0.00375-0.06 0.015 0.03 Ciprofloxacin 0.12-2 0.25 0.5 Trovafloxacin 0.06-0.5 0.12 0.5 Sparfloxacin 0.06-1 0.5 0.5 Clinafloxacin 0.03-0.06 0.06 0.06 Moxifloxacin 0.06-0.5 0.25 0.25 Levofloxacin 0.25-2 0.25 0.25 Cefuroxime <0.00375-0.015 <0.00375 0.015 Streptococcus pyogenes (fully susceptible) (n = = 20) Gemifloxacin 0.0075-0.03 0.015 0.03 Ciprofloxacin 0.12-2 0.25 0.5 Trovafloxacin 0.06-1 0.12 0.25 Sparfloxacin 0.25-1 0.5 1 Clinafloxacin 0.03-0.12 0.03 0.06 Moxifloxacin 0.06-0.25 0.12 0.25 Levofloxacin 0.25-2 0.5 0.5 Cefuroxime 0.0075-0.015 0.0075 0.015 Streptococcus pyogenes (multi-drug resistant) * (n = 20) Gemifloxacin 0.0075-0.015 0.015 0.03 Ciprofloxacin 0.25-1 0.5 0.5 Trovafloxacin 0.12-0.25 0.12 0.25 Sparfloxacin 0.25-1 1 1 Clinafloxacin 0.03-0.06 0.03 0.06 Moxifloxacin 0.06-0.12 0.12 0.12 Levofloxacin 0.25-1 0.5 0.5 Cefuroxime 0.0075-0.015 0-0075 0.015 *Multi-drug resistant = simultaneously resistant to erythromycin, clindamycin and tetracycline Table 10. MICs of Gemifloxacin and Comparative Drugs Against 100 strains of //, influenzae Microrganism and antimicrobial MIC (μg/ml) Range MIC50 MICgo Haemophilus influenzae (n = = 100) Gemifloxacin ≤0.0075-0.06 <0.0075 <0.00075 Ciprofloxacin <0.0075-0.5 <0.00075 0.015 Trovafloxacin <0.0075-0.25 <0.00075 0.06 Sparfloxacin ≤0.0075-0.25 0.015 0.03 Clinafloxacin <0.0075-0.06 <0.00075 <0.00075 Moxifloxacin <0.0075-0.12 0.03 0.06 Levofloxacin <0.0075-0.5 0.015 0.03 Cefuroxime 0.12-4 0.5 1 Microrganism and antimicrobial MIC (μg/ml) Range MICso MIC 90 Haemophilus influenzae (β-lactamase negative) (n = 80) Gemifloxacin <0.0075-0.015 <0.0075 <0.0075 Ciprofloxacin <0.0075-0.5 <0.0075 0.015 Trovafloxacin <0.0075-0.25 ≤0.0075 0.015 Sparfloxacin <0.0075-0.25 0.015 0.25 Clinafloxacin ≤0.0075-0.06 <0.0075 ≤0.0075 Moxifloxacin <0.0075-0.06 0.03 0.06 Levofloxacin <0.0075-0.5 0.015 0.015 Cefuroxime 0.25-1 0.5 1 Haemophilus influenzae (β-lactamase positive) (n = 20) Gemifloxacin <0.0075-0.06 <0.0075 0.015 Ciprofloxacin <0.0075-0.015 <0.0075 0.015 Trovafloxacin <0.0075-0.06 ≤0.0075 0.06 Sparfloxacin <0.0075-0.12 0.015 0.03 Clinafloxacin <0.0075-0.25 <0.0075 <0.0075 Moxifloxacin <0.0075-0.06 0.015 0.015 Levofloxacin <0.0075-0.03 0.015 0.03 Cefuroxime 0.12-4 0.5 1 Table 11. MICs of Gemifloxacin and Comparative Drugs against 50 Strains of M. catarrhalis Microrganism and antimicrobial MIC (μg/ml) Range MIC 50 MIC 90 Moraxella catarrhalis (n = 50) Gemifloxacin <0.00375-0.03 0.015 0.015 Ciprofloxacin <0.00375-0.06 0.03 0.03 Trovafloxacin <0.00375-0.06 0.015 0.06 Sparfloxacin <0.00375-0.06 0.015 0.03 Clinafloxacin <0.00375-0.015 <0.00375 0.015 Moxifloxacin <0.00375-0.12 0.06 0.06 Levofloxacin <0.00375-0.03 0.015 0.03 Cefuroxime <0.00375-1 0.25 1 Microrganism and antimicrobial MIC (μg/ml) Range MICso MIC 90 Moraxella catarrhalis (β- lactamase positive) (n = 37 ) Gemifloxacin <0.00375-0.03 0.015 0.015 Ciprofloxacin <0.00375-0.06 0.03 0.03 Trovafloxacin <0.00375-0.06 0.015 0.03 Sparfloxacin <0.00375-0.06 0.015 0.03 Clinafloxacin <0.00375-0.015 <0.00375 0.015 Moxifloxacin <0.00375-0.12 0.03 0.06 Levofloxacin <0.00375-0.03 0.015 0.03 Cefuroxime <0.00375-1 0.25 1 Moraxella catarrhalis (β- lactamase negative) (n = 13) Gemifloxacin <0.00375-0.015 0.015 0.015 Ciprofloxacin <0.00375-0.03 0.015 0.03 Trovafloxacin <0.00375-0.06 0.0075 0.036 Sparfloxacin ≤0.00375-0.06 0.0075 0.06 Clinafloxacin <0.00375-0.015 < 0.00375 0.015 Moxifloxacin <0.00375-0.12 0.015 0.06 Levofloxacin <0.00375-0.03 0.03 0.03 Cefuroxime <0.00375-1 0.12 0.5 Table 12. MICs of Gemifloxacin and Comparative Drugs Against 50 Strains of S. aureus Microrganism and antimicrobial MIC (μg/ml) Range MIC- 50 MICgo Staphylococcus aureus (n = 50) Gemifloxacin <0.00375-0.12 0.06 0.12 Ciprofloxacin 0.06-4 2 4 Trovafloxacin ≤0.00375-0.5 0.12 0.25 Sparfloxacin 0.06-1 0.5 0.5 Clinafloxacin 0.06-0.25 0.12 0.25 Moxifloxacin 0.015-0.5 0.25 0.5 Levofloxacin 0.03-2 1 2 Microrganism and antimicrobial MIC (μg/ml) Range MICso MIC 90 Cefuroxime <0.00375-0.25 0.25 0.25 Staphylococcus aureus (β-lactamase negative) (n = 20) Gemifloxacin 0.06-0.12 0.12 0.12 Ciprofloxacin 0.06-4 2 4 Trovafloxacin <0.00375-0.25 0.12 0.25 Sparfloxacin 0.06-1 0.5 0.5 Clinafloxacin 0.06-0.25 0.12 0.25 Moxifloxacin 0.06-0.5 0.25 0.5 Levofloxacin 0.03-2 2 2 Cefuroxime 0.0075-0.25 0.25 0.25 Staphylococcus aureus (β-lactamase positive) (n = 20) Gemifloxacin <0.00375-0.12 0.12 0.123 Ciprofloxacin 0.5-8 4 4 Trovafloxacin 0.06-0.5 0.12 0.25 Sparfloxacin 0.12-1 0.5 0.5 Clinafloxacin 0.06-0.25 0.12 0.25 Moxifloxacin 0.12-0.5 0.25 0.5 Levofloxacin 1-2 1 2 Cefuroxime 0.06-0.25 0.25 0.25 Staphylococcus aureus (β-lactamase positive and erythromycin resistant) (n = 10) Gemifloxacin 0.06-0.12 0.06 0.06 Ciprofloxacin 0.5-2 1 2 Trovafloxacin <0.00375-0.25 0.12 0.25 Sparfloxacin 0.25-1 0.25 0.5 Clinafloxacin 0.06-0.25 0.12 0.25 Moxifloxacin 0.12-0.5 0.25 0.5 Levofloxacin 0.5-2 1 2 Cefuroxime 0.06-0.25 0.12 0.25 Table 13. MICs of Gemifloxacin and Comparative Drugs Against 50 Strains of K. pneumoniae Microrganism and antimicrobial MIC (μg/ml) Range MICso MIC 90 Klebsiella pneumoniae (n = 50) Gemifloxacin <0.0075-1 0.03 0.25 Trovafloxacin <0.0075-0.5 0.06 0.5 Sparfloxacin <0.0075-1 0.06 0.5 Clinafloxacin <0.0075-1 0.015 1 Moxifloxacin 0.015-1 0.06 0.5 Ciprofloxacin <0.0075-1 0.12 0.5 Levofloxacin 0.15-1 0.06 0.5 Cefuroxime 0.25->128 2 128 Klebsiella pneumoniae (extended spectrum β-lactamase positive) (n = 20) Gemifloxacin 0.03-1 0.25 0.5 Trovafloxacin 0.06-0.5 0.5 0.5 Sparfloxacin 0.03-0.5 0.5 0.5 Clinafloxacin ≤0.0075-1 ≤0.0075 1 Moxifloxacin 0.06-1 0.5 1 Ciprofloxacin 0.015-0.5 0.25 0.5 Levofloxacin 0.06-1 0.5 0.5 Cefuroxime 1->128 128 >128 Klebsiella pneumoniae (extended spectrum β-lactamase negative) (n = 30) Gemifloxacin <0.0075-0.12 0.015 0.06 Trovafloxacin <0.0075-0.015 0.06 0.12 Sparfloxacin <0.0075-0.25 0.03 0.12 Clinafloxacin <0.0075-0.12 <0.0075 0.015 Moxifloxacin 0.015-0.5 0.06 0.25 Ciprofloxacin <0.0075-0.12 0.015 0.03 Levofloxacin 0.015-0.5 0.06 0.12 Against β-lactamase-positive strains there were no significant differences in the MIC ranges of all fluoroquinolones tested in comparison with β-lactamase-negative strains. Towards M. catarrhalis, gemifloxacin showed activity (MIC 90 0.015 μg/ml) superior to that of ciprofloxacin (0.03 μg/ml), sparfloxacin (0.03 μg/ml), levofloxacin (0.03 μg/ml), trovafloxacin (0.06 μg/ml), moxifloxacin (0.06 μg/ml) and cefuroxime (1 μg/ml) and comparable to that of clinafloxacin (0.015 μg/ml). No great differences in activity were noted after grouping M. catarrhalis according to β-lactamase production. The MICs of gemifloxacin and other antimicrobials against oxacillin-susceptible strains of 5. aureus and K. pneumoniae are given in Tables 12 and 13. Gemifloxacin had the lowest MIC 90 S against these microrganisms. The activity of gemifloxacin against S. pneumoniae strains is 4-64 times greater than that of all comparator agents in this study. Gemifloxacin potency towards strains of 5. pyogenes is 2- 32-fold higher than that of the other fluoroquinolones tested. Gemifloxacin and clinafloxacin shows superior activity against H. influenzae and M. catarrhalis strains compared with comparator agents. Gemifloxacin has the lowest MIC 90 s of the compounds tested against 5. aureus and K. pneumoniae. These results indicate a role for gemifloxacin in the treatment of community-acquired respiratory tract infections. The invention provides a method for modulating metabolism of respiratory tract pathogenic bacteria. Skilled artisans can readily choose respiratory tract pathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention can be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by respiratory tract pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with respiratory tract pathogenic bacteria. While a preferred object of the invention provides a method wherein said respiratory tract pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Klebsiella pneumoniae. Other respiratory tract pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against respiratory tract pathenogenic bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against vanous respiratory tract pathogens An objective of these analyses was to determine the in vitro activity of gemifloxacin against recent clinical isolates of Streptococcus pneumoniae and Haemophilus influenzae and to compare its activity to that of other fluoroquinolones The in vitro activity of the new fluoroquinolone gemifloxacin (GEM) was compared with that of trovafloxacin (TRO), grepafloxacin (GRE), levofloxacin (LEV), ofloxacin (OFX) and ciprofloxacin (CIP) against 235 clinical isolates of Streptococcus pneumoniae (65 penicillin- susceptible (PSP), 11 1 penicillin-intermediate (PIP) and 59 penicillin-resistant (PRP)) and 145 isolates of Haemophilus influenzae (115 beta-lactamase negative (HiBla-) and 30 beta-lactamase positive (HιBla+)) Broth microdilution tests were performed in cation-adjusted Mueller-Hinton broth supplemented with blood for pneumococci and in HTM broth for H influenzae, following NCCLS guidelines All microorganisms were inhibited by gemifloxacin at 0 06 μg/ml MIC 90 S of GEM, TRO, GRE and LEV against all (380) isolates tested were 0 03, 0 12, 0 12 and 1 μg/ml respectively Gemifloxacin is a potent agent against respiratory tract pathogens including strains with resistance to cunent therapies Increasing resistance to antimicrobial agents among respiratory tract pathogens is a cause of concern and has increased the need for new antimicrobials with activity against these pathogens Gemifloxacin (SB-265805) is a potent new quinolone, which has an oxime-deπvatized (amino- methyl) pynohdine substituent at C7 confernng excellent activity against both Gram positive and Gram negative pathogens The favorable pharmacokinetics of gemifloxacin make it a promising agent for the therapy of infections for which the cunently marketed quinolone antimicrobials have a limited role, for example, in the treatment of respiratory tract infections A total of 302 recent clinical isolates (1998-1999) of 5 pneumoniae were studied Among those, 98 were penicillin-susceptible (PSP), 124 were penicillin-intermediate (PIP) and 80 were penicillin-resistant (PRP) 28% of the isolates were also erythromycin-resistant Eight hundred recent clinical isolates (1998-1999) of / influenzae were also studied Of these, 234 were β- lactamase negative and 66 were β-lactamase positive Susceptibility testing was performed by the broth microdilution method (NCCLS) using commercially dned microdilution panels (SB-265805 surveillance MIC1 and MIC2, Baxter, MicroScan RUO/IUO, Sacramento, CA) manufactured for this study The panels included gemifloxacin at two-fold concentrations from 0001-256 μg/ml, trovafloxacin, grepafloxacin, levofloxacin and ciprofloxacin at two-fold concentrations from 0015-16 μg/ml, and ofloxacin at two-fold concentrations from 0.06-64 μg/ml. Panels were inoculated with the isolates suspended in the appropriate broth (cation-adjusted Mueller-Hinton broth with 3% lysed horse blood for S. pneumoniae, and Haemophilus Test Medium for H. influenzae) to achieve a final well concentration of 4-7 x 10 5 CFU/ml. MIC readings were performed after incubation at 35°C for 20-24 h in a non- C0 incubator. Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Haemophilus influenzae ATCC 49247, and Streptococcus pneumoniae ATCC 49619 were used as control strains in each run. The comparative in vitro antimicrobial activities of gemifloxacin and other quinolones are shown in Tables 14-17. Gemifloxacin demonstrated the most potent antimicrobial activity among the quinolones tested against 5. pneumoniae and H. influenzae. All 602 isolates were inhibited by gemifloxacin at 0.12 μg/ml. MIC 90 S of gemifloxacin, trovafloxacin, grepafloxacin and levofloxacin against all isolates tested were 0.06, 0.25, 0.12, and 1 μg/ml, respectively. Gemifloxacin has the most potent activity of all the quinolones tested against 5. pneumoniae and H. influenzae. Gemifloxacin is equally active against penicillin-susceptible and penicillin- resistant S. pneumoniae, erythromycin-resistant 5. pneumoniae and β-lactamase positive and β- lactamase negative H. influenzae. Against 5. pneumoniae, gemifloxacin is two-fold more active than grepafloxacin, four-fold more active than trovafloxacin and 16-fold more active than levofloxacin. Against H. influenzae, the activity of gemifloxacin is similar to that of grepafloxacin and trovafloxacin, and is four-fold superior to that of levofloxacin. Gemifloxacin is a potent new quinolone with excellent activity against respiratory tract pathogens, including strains with resistance to cunent antimicrobial agents. Table 14. Comparative in vitro activity of gemifloxacin and other fluoroquinolones against Streptococcus pneumoniae (302 isolates) Isolate (No.) MIC 90 (μg/ml) Gemi Trova Grep? Levo Oflox Cipro Penicillin-sensitive (98) 0.06 0.25 0.12 1 2 2 Penicillin-intermediate (124) 0.03 0.25 0.12 1 4 2 Penicillin-resistant (80) 0.06 0.25 0.12 1 2 2 Erythromycin-sensitive (216) 0.06 0.25 0.25 2 4 2 Erythromycin-resistant (86) 0.03 0.25 0.12 Table 15. Comparative in vitro activity of gemifloxacin with other fluoroquinolones against Streptococcus pneumoniae (302 isolates). All isolates were inhibited by gemifloxacin 0.12 μg/ml Antimicrobial agent MIC (μg/ml) Range MIC 50 MIC, 90 Gemifloxacin <0.0015-0.12 0.03 0.06 Trovafloxacin <0.015-1 0.12 0.25 Grepafloxacin <0.015-0.25 0.03 0.12 Levofloxacin <0.015-2 1 1 Ofloxacin <0.06-4 Ciprofloxacin <0.015-4 Table 16. Comparative in vitro activity of gemifloxacin and other fluoroquinolones against Haemophilus influenzae (300 isolates) Isolate (No.) MICgo (μg/ml) Gemi Trova Grepa Levo Oflox Cipro β-lactamase positive (66) 0.03 0.03 0.03 0.03 0.12 0.03 β-lactamase negative (234) 0.008 <0.015 <0.015 0.03 <0.06 <0.015 Table 17. Comparative in vitro activity of gemifloxacin with other fluoroquinolones against Haemophilus influenzae (300 isolates). All isolates were inhibited by gemifloxacin 0.12 μg/ml Antimicrobial agent MIC (μg/ml) Range MIC 50 MICα Gemifloxacin <0.0015-0.12 0.004 0.008 Trovafloxacin <0.015-0.25 <0.015 <0.015 Grepafloxacin <0.015-0.12 <0.015 <0.015 Levofloxacin <0.015-0.5 <0.015 0.03 Ofloxacin <0.06-0.5 <0.06 <0.06 Ciprofloxacin <0.015-0.5 <0.015 <0.015 The invention provides a method for modulating metabolism of respiratory tract pathogenic bacteria. Skilled artisans can readily choose respiratory tract pathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by respiratory tract pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with respiratory tract pathogenic bacteria. While a preferred object of the invention provides a method wherein said respiratory tract pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae and Haemophilus influenzae. Other respiratory tract pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against respiratory tract pathenogenic bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various respiratory tract pathogens. An objective of these analyses was to determine the in vitro activity of gemifloxacin against representative isolates of common respiratory tract pathogens, including quinolone-resistant strains. The in vitro activity of gemifloxacin was compared to those of sparfloxacin, ciprofloxacin, levofloxacin, tosufloxacin, trovafloxacin, cefditoren, cefaclor and amoxycillin. MIC values were determined by an agar dilution method. Certain quinolones, such as sparfloxacin and tosufloxacin, which have improved activity against Gram positive bacteria, are available for clinical use in Japan. However, these agents are not potent enough against Gram positive bacteria to treat respiratory tract infections caused by staphylococci and streptococci, although they are effective against the respiratory pathogens Haemophilus influenzae and Moraxella catarrhalis. The potential of gemifloxacin in the treatment of respiratory tract infections depends upon demonstrating its activity against 5. pneumoniae as well as H. influenzae and M. catarrhalis. This is because these bacterial species are the most common pathogens associated with respiratory tract infections, including community-acquired pneumonia and acute exacerbation of chronic bronchitis. Moreover, activity against the increasingly common antimicrobial-resistant strains of S. pnuemoniae would further enhance the potential of gemifloxacin as an agent for empiric use in respiratory tract infections. This study investigates the in vitro activity of gemifloxacin compared with those of other quinolones against pathogens involved in respiratory tract infections, including ciprofloxacin- resistant S. pneumoniae. Clinical isolates and quinolone-resistant strains were collected in Kitasato University School of Medicine, Kanagawa, Japan. MICs were determined by the two-fold serial agar dilution method with Sensitivity Disk agar-N, which was supplemented with 5% defibrinated horse blood for streptococci, and with 5% Fildes enrichment (Difco) for Haemophilus. One loopful of an inoculum conesponding to approximately 10 4 CFU was applied with an inoculating apparatus (Microplanter; Saku a Seisakusho) to drug-containing agar plates, and the plates were incubated for l8 h at 37°C. Comparative in vitro activities of gemifloxacin against respiratory tract pathogens are shown in Tables 18-20, and against quinolone-resistant strains in Table 21. Gemifloxacin demonstrates high activity against the common respiratory tract pathogens, indicating potential for the treatment of respiratory tract infections. Gemifloxacin is the most active compound tested against ciprofloxacin-resistant S. pneumoniae as well as ciprofloxacin- susceptible S. pneumoniae. Bacterial strains highly resistant to gemifloxacin would not easily be developed due to a single mutation. Against Gram negative clinical isolates of / , influenzae and M. catarrhalis, the activity of gemifloxacin was similar to other quinolones, including ciprofloxacin. Gemifloxacin shows activity comparable with trovafloxacin, but superior to the other quinolones tested against MSSA and MRSA. The activity of gemifloxacin against S. pneumoniae (MIC 90 0.031 μg/ml) is 4-fold and 8- fold more potent than trovafloxacin and sparfloxacin, respectively, and is considerably more potent than the other quinolones tested. Gemifloxacin (MIC 90 0.063 μg/ml) is the most potent agent against penicillin-resistant strains, erythromycin-resistant strains and minocycline-resistant strains of 5. pneumoniae. Against quinolone-resistant clinical isolates of 5. pneumoniae (ciprofloxacin MIC >8 μg/ml), gemifloxacin exhibits the most potent activity of all the agents tested (MIC 90 0.5 μg/ml). Gemifloxacin also shows the most potent activity against E. coli mutated in the DNA gyrase, with a MIC 50 of 0.032 μg/ml and MIC 90 of 0.25 μg/ml. The MIC of gemifloxacin (0.031 μg/ml) increased only 2-4-fold against S. aureus KU2240 with a single mutation in NorA, DNA gyrase or topoisomerase IV. Against the same strains with double mutation in both DNA gyrase and topoisomerase IV, MICs increased to 2 μg/ml and 32 μg/ml, respectively. Gemifloxacin exhibits potent anti-bacterial activity against common respiratory tract pathogens, including quinolone-resistant strains, indicating potential for the treatment of respiratory tract infections. Moreover, these analyses indicate that bacterial strains highly resistant to gemifloxacin can not easily be developed by single mutation. Table 18. Comparative In Vitro Activities of Gemifloxacin Against Clinical Isolates of Haemophilus influenzae and Moraxella catarrhalis Microrganism Antimicrobial MIC (μg/ml) (No. of strains tested) agent Range MICso MIC 90 Haemophilus influenzae (24) Gemifloxacin 0.008-0.031 0.016 0.016 Sparfloxacin <0.004-0.063 0.016 0.031 Ciprofloxacin 0.008-0.031 0.016 0.016 Levofloxacin 0.016-0.031 0.031 0.031 Trovafloxacin <0.004-0.031 0.016 0.031 Cefditoren 0.016-0.5 0.031 0.031 Amoxycillin 0.5->128 1 64 Moraxella catarrhalis (22) Gemifloxacin 0.016-0.031 0.031 0.031 Sparfloxacin 0.016-0.031 0.016 0.031 Ciprofloxacin 0.031-0.063 0.031 0.031 Levofloxacin 0.031-0.063 0.063 0.063 Trovafloxacin 0.016-0.031 0.016 0.031 Cefditoren 0.063-1 0.5 1 Amoxycillin 1-16 8 16 Table 19. Comparative In Vitro Activities of Gemifloxacin Against Clinical Isolates of Staphylococcus aureus. S. aureus strain Antimicrobial agent MIC (μg/ml) (No. of strains tested) Range MIC-50 MICgo Methicillin-susceptible (9) Gemifloxacin 0.031-0.25 0.063 0.25 Sparfloxacin 0.063-0.5 0.125 0.5 Ciprofloxacin 0.25-2 0.5 2 Levofloxacin 0.125-1 0.5 1 Trovafloxacin 0.031-0.5 0.031 0.5 Cefditoren 0.5-1 1 1 Amoxycillin 0.25-128 8 128 Methicillin-resistant (38) Gemifloxacin 0.031-32 1 32 Sparfloxacin 0.063-64 2 64 Ciprofloxacin 0.5->128 16 64 Levofloxacin 0.25-128 8 64 Trovafloxacin 0.031-16 1 16 Cefditoren 32-128 128 128 Amoxycillin 8-64 32 64 Table 20. Comparative In Vitro Activities of Gemifloxacin Against Clinical Isolates of Streptococcus pneumoniae. S. pneumoniae strain Antimicrobial agent MIC (μg/ml) (No. of strains tested) Range MIC 50 MIC 90 S. pneumoniae strain Antimicrobial agent MIC (μg/ml) (No. of strains tested) Range MIC50 MIC 90 Ciprofloxacin-susceptible Gemifloxacin <0.008-0.063 0.031 0.031 (94) Sparfloxacin 0.063-0.5 0.125 0.25 Tosufloxacin 0.063-0.5 0.125 0.25 Ciprofloxacin 0.25-4 1 2 Levofloxacin 0.25-2 0.5 1 Trovafloxacin 0.031-0.25 0.063 0.125 Cefditoren <0.008-2 0.063 0.25 Amoxycillin <0.008-8 0.063 0.5 Ciprofloxacin-resistant Gemifloxacin 0.063-0.5 0.25 0.5 (21 ) Sparfloxacin 0.25-8 4 8 Tosufloxacin 0.25-16 4 8 Ciprofloxacin 8-128 32 64 Levofloxacin 2-32 16 16 Trovafloxacin 0.125-4 2 4 Cefditoren <0.008-1 <0.008 0.25 Amoxycillin 0.016-1 0.016 0.5 Penicillin-resistant (19) Gemifloxacin 0.016-0.063 0.016 0.063 Sparfloxacin 0.063-1 0.125 0.5 Tosufloxacin 0.063-0.5 0.125 0.25 Ciprofloxacin 0.5-8 0.5 4 Levofloxacin 0.5-8 0.5 1 Trovafloxacin 0.031-0.25 0.063 0.25 Cefditoren 0.25-2 0.25 2 Amoxycillin 0.25-8 0.5 8 Erythromycin-resistant Gemifloxacin 0.016-0.5 0.031 0.063 (37) Sparfloxacin 0.125-8 0.25 0.5 Tosufloxacin 0.063-4 0.125 0.5 Ciprofloxacin 0.5-64 1 2 Levofloxacin 0.5-16 1 2 Trovafloxacin 0.063-2 0.063 0.25 Cefditoren <0.008-2 0.063 0.25 Amoxycillin 0.016-8 0.063 0.5 Minocycline-resistant Gemifloxacin 0.016-0.5 0.031 0.063 (37) Sparfloxacin 0.125-8 0.25 0.5 Tosufloxacin 0.063-4 0.125 0.5 Ciprofloxacin 0.25-64 1 2 Levofloxacin 0.25-16 1 2 Trovafloxacin 0.063-2 0.063 0.25 Cefditoren <0.008-2 0.063 0.25 Amoxycillin <0.008-8 0.063 0.5 Table 21. Comparative In Vitro Activities of Gemifloxacin Against Quinolone-resistant Strains of S. aureus, E. coli and P. aeruginosa *Wιld = wild strain, NorA = efflux-mediated quinolone resistant strain, SP = spontaneous mutant in the DNA gyrase, G = mutant in the DNA gyrase; GA = mutant in the DNA gyrase A, GB = mutant in the DNA gyrase B; T = mutant in the DNA topoisomerase IV; G+T = mutant in the DNA gyrase and topoisomerase IV The invention provides a method for modulating metabolism of respiratory tract pathogenic bacteria Skilled artisans can readily choose respiratory tract pathogenic bactena or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bactena useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by respiratory tract pathogenic bactena compnsmg the step of administering an antibacterially effective amount of a composition compnsmg a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with respiratory tract pathogenic bactena While a preferred object of the invention provides a method wherein said respiratory tract pathogenic bacteria is selected from the group consisting of: Haemophilus influenzae, Staphylococcus aureus, Streptococcus pneumoniae, E coli, P aeruginosa and Moraxella catarrhalis Other respiratory tract pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e g. MIC tests The present invention provides, among other things, methods for using a composition compnsmg a quinolone, particularly a gemifloxacin compound against respiratory and genital tract pathenogenic bactena This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various respiratory and genital tract pathogens An objective of these analyses was to determine the MIC of gemifloxacin, which was determined by a broth microdilution method and compared with trovafloxacin (TRO), sparfloxacin (SPA), ciprofloxacin (CIP), levofloxacin (LEV) and tosufloxacin (TOS) against common respiratory tract pathogens and urinary tract pathogens from clinical strains isolated in Japan between 1997 and 1998. Gemifloxacin is the most potent of the quinolones tested against the common respiratory tract pathogens of S. pneumoniae, S. pyogenes, H. influenzae and M. catarrhalis. Cross-resistance to macrolides and β-lactams was not detected for any quinolone against S. pneumoniae. Gemifloxacin had the most potent in vitro activity against urinary tract pathogens, such as E. coli and Enterococcus spp. including vancomycin-resistant enterococci. Results also indicated comparable activity to the other quinolones against CIP-R E. coli. These results suggest that gemifloxacin is an extremely potent agent against respiratory tract and urinary tract pathogens. Gemifloxacin has been evaluated in the USA, Europe and Korea and shows potent in vitro activity against a wide range of Gram negative and Gram positive pathogens, particularly Streptococcus pneumoniae and other respiratory tract pathogens. A purpose of this study was to determine and compare the MICs of gemifloxacin, sparfloxacin, ciprofloxacin, trovafloxacin, levofloxacin and tosufloxacin against a wide variety of Japanese clinical isolates including respiratory and urinary tract pathogens. A total of 1 100 clinical isolates were tested. Most strains were isolated from Omori Hospital at Toho University School of Medicine,Tokyo, Japan, between 1997 and 1998. MICs were determined using the NCCLS (NCCLS, 4th ed., M7-A4, Wayne, PA (1997)) recommended procedure for broth microdilution, except for Neisseria gonorrhoeae. Streptococcus spp., Haemophilus influenzae and Moraxella catarrhalis were tested with cation-adjusted Mueller-Hinton broth supplemented with 5% lysed horse blood, NAD and yeast extract. N. gonorrhoeae isolates were tested by an agar dilution method using the GC II agar base and 1 % defined growth supplement. The in vitro activity of gemifloxacin and the other quinolones are summarized in Tables 22-25. The number of isolates of each bacterial species is also shown. Isolates were obtained from sputum or tracheal lavage or from swabs of the pharynx or nasal cavity in patients with RTI; from the urine, urinary catheter or urinary discharge in patients with UTI. Comparative activities against some drug-resistant strains of Gram positive cocci are listed separately in Table 26. Gemifloxacin showed the most potent activity of all the antimicrobial agents tested against the common respiratory tract pathogens of Streptococcus pyogenes, H. influenzae, M. catarrhalis and S. pneumoniae, including amoxicillin-resistant and macrolide-resistant strains. Against the urinary tract pathogens, ciprofloxacin-resistant and -susceptible Enterococcus faecalis, gemifloxacin exhibits the most potent activity of the antimicrobial agents tested. Gemifloxacin also has activity against ciprofloxacin-susceptible Escherichia coli and other Enterobacteπaceae However, against Enterococcus faecium and ciprofloxacin-resistant E coli, gemifloxacin and the other quinolones gemifloxacin has similarly limited activity Against quinolone-resistant S pneumoniae, the activity of gemifloxacin is 2-128 fold higher than that of the other quinolones. Against most quinolone-resistant Staphylococcus aureus and vancomycin- resistant Enterococcus spp , the activity of gemifloxacin is more potent than that of the other quinolones The antimicrobial activity of gemifloxacin against common Japanese respiratory tract and urinary tract pathogens examined in this study indicates that gemifloxacin can be a highly potent agent for the treatment of RTI and UTI in Japan Table 22 Antimicrobial Activity of Gemifloxacin and Other Quinolones Against Gram Positive Pathogens ciprofloxacin resistant SPA 0.5 - 64 16 64 Enterococcus faecium GEM 0.063 - 64 16 64 Oxacillin susceptible = MIC <2 μg/ml, oxacillin resistant = MIC >4 μg/ml, amoxicillin susceptible = MIC <0 5 μg/ml, amoxicillin resistant = MIC ≥1 μg/ml, erythromycin susceptible = MIC <025 μg/ml, erythromycin resistant = MIC >0 5 μg/ml, ciprofloxacin susceptible = MIC <1 μg/ml, ciprofloxacin resistant = MIC >2 μg/ml Table 23. Antimicrobial Activity of Gemifloxacin and Other Quinolones Against Aerobic Gram Negative Pathogens Klebsiella oxytoca GEM <0 008 - 32 0 032 SPA 0 016 - 32 0 063 Ciprofloxacin susceptible = MIC ≤1 μg/ml; ciprofloxacin resistant = MIC >2 μg/ml; "MICβo value Table 24. Antimicrobial Activity of Gemifloxacin and Other Quinolones Against Anaerobic Gram Negative Bacteria Table 25. Antimicrobial Activity of Gemifloxacin and Other Quinolones Against Fastidious Gram Negative Respiratory and Genital Tract Pathogens Table 26 Antimicrobial Activity of Gemifloxacin and Other Quinolones Against Drug-resistant Strains of Gram Positive Cocci Microrganism Strain MIC (μg/ml) GEM SPA CIP TRO LEV TOS Staphylococcus aureus TMS1 * 0 032 0 125 1 0 125 0 5 0 25 quinolone resistant TMS2 * 1 2 4 0 5 4 2 TMS3 32 128 >128 128 >128 >16 TMS4 4 8 16 0 5 16 4 TMS5 2 8 16 1 4 4 TMS6 0 25 2 8 0 5 2 2 Streptococcus pneumoniae TMS1 0 032 0 5 2 0 25 1 0 5 quinolone resistant TMS2 0 5 8 64 1 16 8 Enterococcus faecium (vanA) TMS1 16 32 >128 8 64 >16 vancomycin resistant TMS2 2 0 5 2 1 2 2 TMS3 4 64 32 8 32 >16 TMS4 4 64 32 8 32 >16 TMS5 2 2 4 2 4 4 Enterococcus faecium (vanB) TMS6 32 64 64 32 32 >16 vancomycin resistant TMS7 32 32 128 32 32 >16 Enterococcus gallinarum (vanCl ) TMS1 0 032 0 25 1 0 125 1 0 25 TMS2 0 125 0 5 2 0 25 2 0 5 TMS3 0 125 0 5 2 0 25 1 0 5 TMS4 0 032 0 25 0 5 0 063 0 5 0 125 "Spontaneous mutant resistant to ciprofloxacin Vancomycin-resistant, MIC >8 μg/ml The invention provides a method for modulating metabolism of respiratory or urinary tract pathogenic bacteria. Skilled artisans can readily choose respiratory or urinary tract pathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by respiratory or urinary tract pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with respiratory or urinary tract pathogenic bacteria. While a preferred object of the invention provides a method wherein said respiratory or urinary tract pathogenic bacteria is selected from the group consisting of: Staphylococcus aureus (including oxacillin-susceptible, oxacillin-resistant, and quinolone-resistant strains), Staphylococcus epidermidis (including oxacillin-susceptible, oxacillin-resistant strains), Streptococcus pneumoniae (including qauinolone-resistant, amoxicillin-susceptible, amoxicillin- resistant, erythromycin-susceptible and erythromycin-resistant strains), Streptococcus pyrogenes, Enterococcus faecalis (including ciprofloxacin-susceptible and ciprofloxacin-resistant strains), Enterococcus faecium (including vanA and vanB vancomycin-resistant strains), Enterococcus gallinarum (including vanCl), Escherichia coli (including ciprofloxacin-susceptible and ciprofloxacin-resistant strains), Citrobacter freundii, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter cloacae, Salmonella spp., Shigella spp., Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Serratia marcescens, Pseudomonas aeruginosa, Bukolderia cepacia, Stenotrophomonas maltophilia, Acintobacter calcoaceticus, Haemophilus influenzae, Moraxella catarrhalis, and Neisseria gonorrhoeae. Other respiratory or urinary tract pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against anaerobic pathenogenic bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various anaerobic pathogens. An objective of these analyses was to determine the in vitro activity of gemifloxacin against a variety of anaerobic bacteria compared with that of trovafloxacin, sparfloxacin, ciprofloxacin and imipenem.. The in vitro activity of gemifloxacin was compared with that of trovafloxacin, sparfloxacin, ciprofloxacin and imipenem against 68 anaerobic reference strains and 491 recent clinical isolates. MICs were determined by the NCCLS-recommended agar dilution method, using Brucella HK agar, supplemented with 5% laked sheep blood. Against the reference strains, gemifloxacin shows more potent activity than sparfloxacin and ciprofloxacin. Gemifloxacin is more active than trovafloxacin against Gram positive pathogens, but less active than trovafloxacin against Gram negative pathogens. Against clinical isolates, the rank order of potency against Bacteroides spp., Prevotella bivia and other Prevotella spp. was trovafloxacin > gemifloxacin Ξ sparfloxacin > ciprofloxacin. The MIC 90 values of gemifloxacin, trovafloxacin, sparfloxacin and ciprofloxacin against these Gram negative pathogens were 8-32 μg/ml, 1-8 μg/ml, 4-32 μg/ml, 32-256 μg/ml, respectively. Gemifloxacin shows potent activity, however, against other Gram negative pathogens (Prevotella intermedia, Porphyromonas spp. and Fusobacterium nucleatum), with MIC s of 0.125-0.5 μg/ml. Against almost all anaerobic cocci and Gram positive pathogens, gemifloxacin is the most active quinolone tested. The MIC s of gemifloxacin against these isolates (except Peptostreptococcus magnus and Clostridium difficile) are 0.125-2 μg/ml. Gemifloxacin is less active against C. difficile. Cross-resistance is observed among quinolones. From these results, it is indicated that gemifloxacin has good clinical potential for the treatment of Gram positive anaerobe infections but limited activity against Gram negative anaerobes. Gemifloxacin has been reported that this agent is highly active against Gram positive and Gram negative aerobic pathogens (Cormican, et al., Antimicrobial Agents Chemotherapy, 41 : 204- 21 1 (1997); Hohl, et al., Clinical Microbiology Infections, 4: 280-284 (1998)). By contrast, the antimicrobial activity of gemifloxacin against anaerobic pathogens is not well known. This study investigated the in vitro activity of gemifloxacin against a variety of anaerobic bacteria compared with that of trovafloxacin, sparfloxacin, ciprofloxacin and imipenem. A total of 68 Gram positive and Gram negative reference strains of anaerobic pathogens and some fastidious microaerophilic anaerobes were examined. In addition, 491 clinical strains isolated between 1994 and 1997 were also studied. Propionibacterium acnes strains, which were mainly isolated from purulent specimens were included in the study. Gemifloxacin, trovafloxacin, sparfloxacin, ciprofloxacin and imipenem of known potency were used. MICs were determined by an agar dilution method. Brucella HK agar (Kyokuto, Tokyo, Japan) supplemented with 5% laked sheep blood was used as the test medium. A 10 5 CFU/spot of test strains was inoculated and incubated at 37°C in an anaerobic chamber (82% N , 10% C0 2 , 8% H 2 ) for 48 h Bacteroides fragilis ATCC25285 and GAI 5562 were used as control strains The MIC data are shown in Tables 27-29 Overall, gemifloxacin shows more potent activity than sparfloxacin and ciprofloxacin Gemifloxacin is more active than trovafloxacin against most of the Gram positive and some Gram negative pathogens, but is less active than trovafloxacin against Bacteroides spp and Prevotella spp (except Prevotella intermedia) Bacteroides spp , Prevotella bivia and Clostridium difficile are less susceptible to gemifloxacin Gemifloxacin shows potent activity against other Gram positive and Gram negative anaerobes Results indicate that gemifloxacin has clinical potential for the treatment of Gram positive anaerobe infections Table 27. Antimicrobial activity of gemifloxacin and other agents against Gram positive anaerobic and facultative anaerobic pathogens Table 28 Antimicrobial activity of gemifloxacin and other agents against Gram negative anaerobic pathogens and facultative anaerobic pathogens Table 29. In vitro activity of gemifloxacin and other agents against clinical isolates of anaerobic pathogens Antimicrobial Isolate (No of organisms) and MIC (μg/ml) agent Peptostreptococcus anaerobius (20) Peptostreptococcus asccharolyticus (25) Peptostreptococcus magnus (25, Range MICso MIC90 Range MICso MIC90 Range MICso MIC90 Gemifloxacin 0 06-8 0 125 0 125 0 06-0 25 0 125 0 125 ≤0 03-8 ≤0 03 8 Trovafloxacin 0 06-8 0 06 0 125 0 25-2 0 5 0 5 <0 03-16 0 25 16 Sparfloxacin 0 5-64 1 1 0 125-8 0 25 0 25 <0 03-64 0 25 64 Ciprofloxacin 0 5-16 0 5 1 2-8 2 2 0 125-32 0 5 32 Imipenem 0 06-8 0 25 4 ≤O 03-0 125 ≤0 03 0 06 <0 03-0 5 0 125 0 5 Peptostreptococcus micros (25) Propionibactenum acnes (25) Actinomyces spp (21 ) Range MICso MIC90 Range MICso MIC90 Range MICso MICgo Gemifloxacin 0 06-4 0 125 0 125 0 125-0 25 0 125 0 25 0 125-16 1 2 Trovafloxacin ≤0 03-1 0 06 0 06 0 25-1 0 5 1 0 25-16 4 4 Sparfloxacin 0 25-64 0 5 1 0 125-0 5 0 25 0 25 0 5-32 4 8 Ciprofloxacin 0 5-16 0 5 1 0 25-0 5 0 5 0 5 2-32 8 16 Imipenem 0 06-0 25 0 125 0 125 <0 03-0 125 ≤0 03 0 06 ≤O 03-16 0 125 2 Clostridium difficile (25) Clostridium pertnngens (22) Bacteroides distasonis (38) Range MICso MIC90 Range MIC50 MIC90 Range MICso MIC90 Gemifloxacin 1-32 4 32 ≤O 03-0 125 0 06 0 125 0 5-32 1 16 Trovafloxacin 0 5-32 4 32 ≤0 03-1 0 125 0 25 0 125-8 0 5 4 Sparfloxacin 4-128 8 64 ≤O 03-1 025 0 5 0 5-32 2 16 Ciprofloxacin 8-256 16 64 0 125-4 0 5 1 2-256 4 64 Imipenem 2-8 4 8 <0 03-0 25 0 125 0 25 0 5-8 1 4 Bacteroides fragilis (50) Bacteroides thetaiotaomicron (49) Bacteroides uniformis (18) Range MICso MIC90 Range MIC50 MIC90 Range MICso MIC90 Gemifloxacin 0 5-64 1 16 0 5-32 2 16 1-64 4 8 Isolate (No of organisms) and MIC (μg/ml) Trovafloxacin 0 125-8 0 25 2 0 125-4 0 5 1 0 25-8 0 5 8 Sparfloxacin 0 5-32 1 16 0 5-16 2 4 1-32 2 32 Ciprofloxacin 2-128 4 64 8-128 16 64 16-256 32 128 Imipenem 0 06-2 0 5 1 0 25-8 0 5 1 0 25-4 0 5 1 Bacteroides vulgatus (10) Other B fragilis group organisms (21 ) a Imipenem-resistant B fragilis group organisms (11 f Range MICso MIC90 Range MICso MIC90 Range MICso MIC90 Gemifloxacin 0 5-16 1 16 1-32 2 8 1-128 8 16 Trovafloxacin 0 125-8 0 125 8 0 125-4 0 5 2 0 125-16 0 25 2 Sparfloxacin 0 5-32 0 5 32 0 5-16 2 8 0 5-128 2 8 Ciprofloxacin 8-256 16 256 4-128 16 64 2-256 32 32 Imipenem 0 125-2 0 5 2 0 125-1 0 5 1 8->256 64 256 Prevotella bivia (20) Prevotella intermedia (20) Other Prevotella spp (18) Range MICso MIC 90 Range MICso MIC90 Range MICso MIC90 Gemifloxacin 4-64 16 32 0 25-1 0 5 0 5 0 25-8 1 4 Ul Ul Trovafloxacin 1-8 2 8 0 25-2 0 5 1 0 5-4 1 2 Sparfloxacin 4-64 8 32 1-16 1 2 1-32 2 16 Ciprofloxacin 8-128 16 64 0 5-4 0 5 1 0 5-32 1 8 Imipenem ≤O 03-0 125 0 06 0 125 ≤O 03-0 06 0 06 0 06 ≤O 03-1 0 06 0 125 Porphyromonas spp (14) Fusobacterium nucleatum (24) Veillonella spp (10) Range MICso IC90 Range MICso MIC90 Range MICso MICgo Gemifloxacin 0 06-0 125 0 125 0 125 0 06-0 125 0 125 0 125 ≤0 03-16 0 06 2 Trovafloxacin ≤0 03-0 5 0 06 0 25 0 125-0 5 0 5 0 5 0 125-64 0 25 8 Sparfloxacin 0 125-2 0 25 1 0 25-1 0 5 1 0 06-32 0 125 8 Ciprofloxacin 0 25-1 0 5 1 1-2 2 2 0 06-16 0 125 4 Imipenem ≤O 03-0 06 ≤0 03 0 06 ≤O 03-0 5 0 125 0 25 0 06-1 0 125 0 5 B caccae, 7 strains, B eggerthii, 6 strains, B ovatus, 8 strains b 5 distasonis, 1 strain, B fragilis, 10 strains The invention provides a method for modulating metabolism of anaerobic pathogenic bacteria. Skilled artisans can readily choose anaerobic pathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by anaerobic pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with anaerobic pathogenic bacteria. While a preferred object of the invention provides a method wherein said anaerobic pathogenic bacteria is selected from the group consisting of: Peptostreptococcus anaerobius, Peptostreptococcus asaccharolyticus, Peptostreptococcus indolicus, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus prevotii, Staphylococcus saccharolyticus, Atopobium parvulus, Streptococcus constellatus, Streptococcus intermedius, Gemella morbillorum, Clostridium clostridioforme, Clostridium difficile, Clostridium perfringens, Clostridium septicum, Clostridium sordellii, Clostridium ramosum, Propionibacterium acnes, Propionibacterium granulosum, Eubacterium lentum, Actinomyces odontolyticus, Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium pseudolongum, Lactobacillus, Lactobacillus brevis subsp. Brevis, Lactobacillus casei subsp. casei, Lactobacillus fermentum, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus salivarius subsp. salivarius, bacteroides fragilis, Bacteroides vulgatus, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides eggerthii, Bacteroides ureolyticus, Campylobacter gracilis, Sutterella wadsworthensis, Prevotella bivia, Prevotella buccae, Prevotella corporis, Prevotella heparinolytica, Prevotella intermedia, Prevotella melaninogenica, Prevotella oralis, Prevotella oris, Porphyromonas asaccharolytica, Porphylomonas gingivalis, Fusobacterium nucleatum, Fusobacterium varium, Fusobacterium necrophorum, Bilophilla wadsworthia, Desulfomonas pigra, Capnocytophaga ochracea, Veillonella parvula, Veillonella dispar, Peptostreptococcus anaerobius, Peptostreptococcus asccharolyticus, Peptostreptococcus magnus, Peptostreptococcus micros, Propionibacterium acnes, Actinomyces spp., Clostridium difficile, Clostridium perfringens, Bacteroides distasonis, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, B. fragilis group organisms (B. caccae; B. eggerthii, B. ovatus), Imipenem-resistant B. fragilis group organisms (B. distasonis, B. fragilis), Prevotella bivia, Prevotella intermedia, Other Prevotella spp., Porphyromonas spp., Fusobacterium nucleatum, and Veillonella spp.. Other anaerobic pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against uropathogenic bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various uropathogens. An objective of these analyses was to determine the urinary excretion and bactericidal titers (UBT) among volunteers of 320 mg gemifloxacin versus 400 mg ofloxacin. In a randomized cross-over study 16 volunteers (8 males, 8 females) received a single oral dose of 320 mg gemifloxacin versus 400 mg ofloxacin to assess the urinary excretion and bactericidal titers (UBT) in intervals up to 144 h. Ofloxacin showed higher urinary concentrations compared with gemifloxacin. The cumulative excretion (median, range) of gemifloxacin was 29.7% (8.4-48.7%) and that of ofloxacin 84.3% (46.5-95.2%) of the parent drug administered. The UBTs, i.e. the highest two-fold dilution (antibiotic free urine as diluent) of urine still bactericidal, were determined for a reference strain and nine uropathogens with the following MICs (μg/ml) for gemifloxacin/ofloxacin: E. coli ATCC 25922 (0.016/0.06), K pneumoniae (0.03/0.06), P. mirabilis (0.125/0.125). E. coli (0.06/0.5), P. aeruginosa (1/4), S. aureus (0.008/0.25), E. faecalis (0.06/2), S. aureus (0.25/4), E. faecalis (0.5/32) and S. aureus (2/32). Generally the UBTs for Gram negative uropathogens were higher for ofloxacin than for gemifloxacin and for Gram positive uropathogens the UBTs were higher for gemifloxacin than for ofloxacin. For Enterobacteriaceae and susceptible Gram positive uropathogens, the initial UBTs were all at least 1 :8 for either drug and thus the differences are not likely to be clinically relevant. However, if a peak UBT of at least 1 :4 is considered desirable for treating complicated UTI, the gemifloxacin 320 mg dose can be too low for P. aeruginosa or a fluoroquinolone-resistant strain. Both gemifloxacin 320 mg and ofloxacin 400 mg can be inadequate for S. aureus (MIC 2/32) and for E. faecalis (MIC 0.5/32). The study indicates that a gemifloxacin 320 mg dose can be generally recommended for an UTI clinical trial. Gemifloxacin, a new fluoroquinolone, has a broad antibacterial spectrum in vitro against Gram negative bacteria such as Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumoniae, but also against Gram positive bacteria such as streptococci and staphylococci. Gemifloxacin has a long plasma half life (tι /2 ) and is approximately 20-30% excreted unchanged into urine, thereby reaching urinary concentrations which should provide sufficient antibacterial activity against most bacteria involved in the pathogenesis of UTI. A single oral dose of gemifloxacin (320 mg) was compared to ofloxacin (400 mg) in healthy volunteers in a combined pharmacokinetic/pharmacodynamic model determining their respective plasma and urinary concentrations and their urinary bactericidal activities against isolates of most common uropathogenic bacterial species. One study was an open, randomized, crossover design trial, including 16 healthy volunteers (8 male, 8 female), median age (range): 31.5 years (18-40); median body weight: 66.5 kg (53.3-96.7); median height: 173.5 cm ( 160-179). Subjects received a single dose of 320 mg gemifloxacin or 400 mg ofloxacin with 14 days between doses. Urine collections were made at -12-0 h pre-dose and 0-6, 6-12, 12-24, 24-48, 48-72, 72-96, 96-120 and 120-144 h post-dose. Gemifloxacin was assayed by HPLC/MS/MS (LLQ in plasma and urine was 0.0100 μg/ml). Ofloxacin was assayed by HPLC (LLQ in plasma was 0.00363 μg/ml and in urine 0.208 μg/ml). MICs and MBCs were determined by a microdilution method with Mueller-Hinton broth. An inoculum of 1.3-9.4 x 10 5 colony forming units (CFU) per ml was used. MIC was defined as the lowest concentration inhibiting visible growth after incubation at 37°C for 18 h and MBC by counting the CFUs on antibiotic-free Columbia agar supplemented with 5% blood, after additional incubation at 37°C for 18 h. Bactericidal activity was defined as a reduction of CFUs of >99.9% (>3 logs). Serial dilutions, ranging from 1 :2 to 1 : 1024 were prepared using drug free urine and UBTs determined by microdilution on a microplate with a final inoculum = 10 5 CFU/ l. Bactericidal activity was determined according to recommended guidelines of the NCCLS (NCCLS, 12(19), M26-T, Villanova, PA (1992)). An UBT of 0 was taken as no bactericidal activity and an UBT of 1 :1 was used only when undiluted urine displayed bactericidal activity. Strains included a reference strain E. coli ATCC 25922, susceptible to nalidixic acid (Nal- S) and the following clinical isolates obtained from complicated UTI patients: E. coli (resistant to nalidixic acid), K. pneumoniae, P. mirabilis , P. aeruginosa, Streptococcus aureus (3 strains) and Enterococcus faecalis (2 strains). UBTs transformed into ordinal data; scale: 1 for UBT = 0 to 12 for UBT >1024. The area under the UBT vs. time curve (AUBTC) was calculated by trapezoidal-rule. No formal statistical analysis was conducted. Laboratory parameters displayed no clinically relevant changes, and there were no clinically significant differences between study phases. Gemifloxacin and ofloxacin were well tolerated in healthy male and female volunteers. Urinary pH and volumes similar in the two study phases. Median urinary drug concentrations was determined. Median (range) renal excretion up to 144 h was 84.3% (46.5- 95.2%) of dose for ofloxacin and 29.7% (8.4-48.7%) of dose for gemifloxacin. MICs and MBCs (range 0.008-128μg/ml) for gemifloxacin and ofloxacin for each test organism are shown in Table 30. The median UBTs of both study drugs against the test organisms was detemined. For Gram negative uropathogens, UBT's are generally higher for ofloxacin than for gemifloxacin. For Gram positive uropathogens - UBTs are higher for gemifloxacin than for ofloxacin. Median UBTs of gemifloxacin exceed 0 for 5 days for the reference strain and decrease from 1 :> 1024 to 1: 1. Median UBTs of ofloxacin exceed 0 for 4 days for the reference strain and decrease from 1:>1024 to 1:2. There is a wide range of UBTs although the variant coefficient of the laboratory method was proven to be low (Well, et al., Int. J. Antimicrob. Agents, 10: 31-38 (1998)). As it is the aim of antibacterial treatment to reach efficacy in all treated individuals, the lower range of the UBT results can be regarded relevant for clinical dosage recommendations. Initial UBTs are at least 1 :8 for Enterobacteriaceae and susceptible Gram positive uropathogens for both study drugs. The observed differences are not likely to be clinically relevant. Considering a peak UBT of at least 1 :4 desirable for treating complicated UTI, gemifloxacin 320 mg can be too low for P. aeruginosa or a fluoroquinolone-resistant strain. Both gemifloxacin 320 mg and ofloxacin 400 mg can be inadequate for quinolone-resistant 5. aureus (MIC 2/32), and E. faecalis (MIC 0.5/32). AUBTCs of both study drugs are shown in Table 31. AUBTCs of ofloxacin and gemifloxacin are comparable in the reference strain. AUBTCs in the other test organisms are higher for ofloxacin in Gram negative organisms and higher for gemifloxacin in Gram positive organisms (corresponding with UBT data). Urinary concentrations and renal excretion are higher for ofloxacin than for gemifloxacin. In vitro activity against the test strains is in general higher for gemifloxacin (except for P. mirabilis). UBTs are higher for gemifloxacin in Gram positive strains, whereas in Gram negative strains UBTs are higher for ofloxacin. However, most UBTs are high enough to produce likely clinical efficacy. An oral dosage of 320 mg gemifloxacin once daily could be generally recommended for an UTI clinical trial. Table 30. Minimal Inhibitory Concentrations (MIC)/Minimal Bactericidal Concentrations (MBC) Of Gemifloxacin Versus Ofloxacin Against E. Coli ATCC 25922 and Nine Clinical Isolates Test strain Laboratory Inoculum Gemifloxacin Ofloxacin No. CFU MIC MBC MIC MBC 10 5 /ml (μg/ml) (μg/ml) (μg/ml) (μg/ml) 1 E. coli ATCC 25922 1.3 0.016 0.016 0.06 0.06 2 K. pneumoniae 595 3.7 0.03 0.03 0.06 0.06 3 P. mirabilis 414 2.5 0.125 0.25 0.125 0.125 4 E. coli 523 3.4 0.06 0.06 0.5 0.5 5 P. aeruginosa 568 5.6 1 2 4 4 5 S. aureus 83 7.1 0.008 0.008 0.25 0.25 7 E. faecalis 60 7.0 0.06 0.06 2 2 9 S. aureus 161 9.4 0.25 0.25 4 4 8 S. aureus 636 5.6 2 2 32 32 10 E. faecalis 55 6.0 0.5 2 32 128 Table 31. Area Under the Urinary Bactericidal Titer Curve (AUBTC) for Gemifloxacin and Ofloxacin The invention provides a method for modulating metabolism of uropathogenic bacteria. Skilled artisans can readily choose uropathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by uropathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with uropathogenic bacteria. While a preferred object of the invention provides a method wherein said uropathogenic bacteria is selected from the group consisting of: K. pneumoniae, P. mirabilis, E. coli, P. aeruginosa, S. aureus, and E. faecalis. Other uropathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against nosocomial Gram negative bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various nosocomial Gram negative pathogens. An objective of these analyses was to determine the in vitro activity of gemifloxacin compared with trovafloxacin and grepafloxacin against 322 Gram negative clinical nosocomial isolates, collected in 1998 from six tertiary hospitals in Athens. The newer quinolones are known to have an expanded activity spectrum against Gram positive bacteria. Isolates included Enterobacteriaceae and Pseudomonas aeruginosa from different patients and various sources (urine, pus, blood). The in vitro activity was tested by the agar dilution method and ciprofloxacin, ofloxacin, 2 nd and 3 rd generation cephalosporins, carbapenems and piperacillin were used as comparators. Results are shown in Tables 32-37. Gemifloxacin retains activity against nosocomial Gram negative strains comparable to that of ciprofloxacin, whilst exhibiting better activity against multi-resistant Acinetobacter spp., with a MIC 50 comparable with that of imipenem. Gemifloxacin (SB-265805) is a promising fluoroquinolone with extended spectrum against both Gram positive and Gram negative microrganisms. High resistance rates of nosocomial Gram negative isolates are a devastating reality in Greece, complicating the management and outcome of hospital acquired and ICU infections. An aim of this study was to compare the in vitro activity of gemifloxacin against Greek nosocomial Gram negative isolates with that of other antimicrobial agents. Three hundred twenty -two (322) Gram negative isolates were collected in 1998 (May- October) from six tertiary hospitals in Athens (1 Children's Hospital, 1 Military Hospital, 1 Cancer Hospital and 3 General Hospitals). Isolates included Enterobacteriaceae and Pseudomonas aeruginosa from different infected patients and from various sources (urine, pus, blood). The in vitro activity of gemifloxacin was tested by the agar dilution method according to NCCLS methodology and the following compounds were used as comparators: ciprofloxacin, trovafloxacin, grepafloxacin, ofloxacin, cefoxitin, piperacillin, ceftazidime, imipenem, meropenem, cefepime. Results were expressed as MIC 50 and MIC 90 values and distribution of MICs for each pathogen. Tables 32-37 show the MIC distribution, range, MIC 50 and MIC 90 for each of the antimicrobials tested against the range of test organisms. Gemifloxacin displays activity against nosocomial Gram negative strains comparable with that of ciprofloxacin. Gemifloxacin exhibits improved activity against multi-resistant Acinetobacter spp. (MIC 50 s comparable with that of carbapenems) over ciprofloxacin. Gemifloxacin has the potential to play an important future role in the management of severe hospital acquired and ICU infections. β\ Ul The invention provides a method for modulating metabolism of nosocomial Gram negative pathogenic bacteria. Skilled artisans can readily choose nosocomial Gram negative pathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by nosocomial Gram negative pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with nosocomial Gram negative pathogenic bacteria. While a preferred object of the invention provides a method wherein said nosocomial Gram negative pathogenic bacteria is selected from the group consisting of: Acinetobacter spp., Enterobacter spp., Proteus mirabilis, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa. Other nosocomial Gram negative pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against Gram positive bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various Gram positive pathogens. An objective of these analyses was to determine the comparative in vitro activity of gemifloxacin against a range of Gram positive cocci with that of other quinolones (ofloxacin, ciprofloxacin, grepafloxacin and trovafloxacin) and different classes of antimicrobials (glycopeptides, macrolides, azalides). Gemifloxacin is a fluoroquinolone antimicrobial with a broad spectrum of activity including Gram positive bacteria. Gemifloxacin activity was compared with that of trovafloxacin, grepafloxacin, ciprofloxacin, ofloxacin and vancomycin against 373 Gram positive clinical isolates collected in 1998 in the Athens metropolitan area. Susceptibility testing was performed by agar dilution or epsilometer method (E-test), as recommended by the NCCLS. The broth microdilution technique was used to test gemifloxacin against pneumococci. Results are shown in Tables 38-44. These results indicate that gemifloxacin and trovafloxacin are more potent than comparator quinolones against Gram positive bacteria and especially against pneumococci. There is an increasing amount of evidence showing that the problem of resistance in Gram positive organisms is becoming a global threat. There are reports of methicillin- resistant Staphylococcus aureus (MRSA) strains with intermediate susceptibility to vancomycin (VISA) having made their appearance along with macrolide, β-lactam and even quinolone-resistant pneumococci, (New England Journal of Medicine, 341 : 233-239 (1999) and Enterococcus faecium strains with the VanA phenotype of resistance (high level vancomycin and teicoplanin resistance ). In light of the continuing emergence of increasingly resistant strains, the development of new agents seems urgent. Gemifloxacin (SB-265805) is reported to combine the advantages of the quinolone class of antimicrobials - excellent oral bioavailability, few drug interactions and long half life - with an extremely broad antimicrobial spectrum and an activity even against strains resistant to many other different classes of antimicrobials. A total of 373 Gram positive recent clinical isolates were tested. Of these, the 107 pneumococcal strains were nasopharyngeal isolates from healthy carriers, both children (3-7 years old) and adults ( 18-90 years old), all inhabitants of the metropolitan area of Athens. The specimens were collected during the 1998 winter period. The susceptibility profiles of the strains were assessed using the Epsilometer method (E-test). The isolates were subdivided into two groups according to their penicillin susceptibility patterns (penicillin-susceptible and penicillin-intermediate. All other Gram positives tested were isolated from various sources (blood, urine, pus, sputum, prostatic fluid). These were obtained either from outpatients of the Infectious Diseases Outpatient Clinic of the 4 th Department of Internal Medicine of the University of Athens Medical School or from hospitalized patients in various wards of tertiary hospitals both in the capital area of Athens and the Greek province. The susceptibility of staphylococcal strains to methicillin was tested by the inoculation of oxacillin-containing (at a concentration of 6 μg/ml) McConkey agar plates after a 48 h incubation at 30°C. The subtyping of the enterococcal strains employed the API ID32 Rapid Strep identification system (BioMerieux, Paris ,France). The susceptibility patterns of all those strains were assessed by the agar macrodilution method as recommended by the NCCLS. Results are shown in Tables 38-44. Gemifloxacin is the quinolone with the best anti-pneumococcal activity both against penicillin-susceptible and -intermediate strains (strains with MIC of penicillin >2 μg/ml were not included in the analysis). The activity of Gemifloxacin against enterococcal strains was moderate but with no particular discrimination against E. faecium and E. faecalis strains. Gemifloxacin and trovafloxacin seem equally potent against S. aureus strains irrespective of their methicillin susceptibility. Gemifloxacin also retains excellent in vitro activity against S. epidermidis strains, irrespective of methicillin susceptibility (the best among comparators). Table 38. Activity Against Penicillin-susceptible and -intermediate Streptococcus pneumoniae Determined by E-test Antimicrobial Penicillin-susceptible S. pneumoniae Penicillin-intermediate S. pneumoniae (n = 107) (n = 24) MIC range MICso MICgo MIC range MICso MICgo Gemifloxacin 0.002-0.19 0.032 0.064 0.004-0.125 0.064 0.23 Trovafloxacin 0.008-1 0.094 0.19 0.003-1 0.125 0.38 Grepafloxacin 0.047-1 0.19 0.38 0.047-0.5 0.19 0.38 Ciprofloxacin 0.094-2 0.75 2 0.125->32 0.75 1 Ofloxacin 0.75->32 2 4 0.75-6 2 3 Teicoplanin 0.023-3 0.064 0.38 0.023-0.125 0.064 0.125 Vancomycin 0.064-2 0.5 1 0.19-1.5 0.75 1 Ceftrixone 0.003-0.09 0.012 0.047 0.008-0.75 0.19 0.38 4 Clarithromycin 0.016->25 0.094 0.38 0.016->256 0.094 >256 6 Azithromycin 0.012->25 0.75 3 0.38->256 1 >256 6 -J o The invention provides a method for modulating metabolism of Gram positive pathogenic bacteria. Skilled artisans can readily choose Gram positive pathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. Also provided by the invention is a method of treating or preventing a bacterial infection by Gram positive pathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having an infection with Gram positive pathogenic bacteria. While a preferred object of the invention provides a method wherein said Gram positive pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus (including Methicillin-susceptible and Methicillin-resistant strains), and Staphylococcus epidermidis (including Methicillin-susceptible and Methicillin-resistant strains). Other Gram positive pathogenic bacteria may also be included in the methods. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. The present invention provides, among other things, methods for using a composition comprising a quinolone, particularly a gemifloxacin compound against enteropathogenic bacteria. This invention was based, in part, on analyses evaluating the comparative activity of gemifloxacin against various enteropathogenic bacteria. An objective of these analyses was to determine the in vitro activity of gemifloxacin and other antibiotics against enteropathogenic bacterial strains. Gemifloxacin was compared to trovafloxacin, grepafloxacin, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, nalidixic acid, ampicillin, amoxicillin, cefotaxime, gentamicin, doxycycline, colistin, co-trimoxazole, and for C. jejuni erythromycin Certain classical oral antibiotics used against enteropathogenic bacterial isolates have recently demonstrated a poor in vitro activity (Aarestrup, et al., Antimicrob. Agents Chemother., 41 : 2244-2250 (1997); Ramos, et al., Eur. J. Clin. Microbiol. Infect. Dis., 15: 85- 88 (1996); Sjogren, et al, J. Antimicrob. Chemother., 40: 257-261 (1997); Soriano, et al., J. Antimicrob. Chemother., 34: 157-160 (1994); Stock, et al, J. Antimicrob. Chemother., 43: 37-45 (1999); Stolk-Engelaar, et al., J. Antimicrob. Chemother., 36: 839-843 (1995)) and this fact prompted tests of antibiotics against these organisms. Here, the in vitro activity of gemifloxacin and 15 other antimicrobials was compared against recognized bacterial enteric pathogens and against Hafnia alvei, a bacteria with probable enteric pathogenic capacity (Ismaili, et al., J. Clin. Microbiol., 34: 2973-2979 (1997)). A total of 288 enteropathogenic bacterial isolates from patients with acute gastroenteritis were studied, including 106 Salmonella spp., [S. enteritidis (75), 5. typhimurium (19), S. virchow (5), S. tshiongwe (2), S. newport (1), 5. ohio (1), S. hadar (2), and S. georgia (1)], 32 Hafnia alvei, 22 Yersinia enterocolitica, 21 Shigella spp., [S. sonnei (15), S. flexneri (5), and S. boydii (1)], 16 Aeromonas spp. [A. hydrophila (12), and A. sobria (4)], and 91 Campylobacter jejuni. The microorganisms were isolated from 1996 to 1999 from stool samples. The strains were stored in skimmed-milk at -80 °C until studied. The antibiotics tested were gemifloxacin, trovafloxacin, grepafloxacin, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, nalidixic acid, ampicillin, amoxicillin, cefotaxime, gentamicin, doxycycline, colistin, co-trimoxazole, and for C. jejuni erythromycin. MICs were determined by an agar dilution method (NCCLS, 4th ed., M7-A4, Villanova, PA (1997)) on Mueller-Hinton agar, supplemented with 5% sheep blood for Campylobacter jejuni isolates. The plates were incubated aerobically at 35 °C for 24 h, except for Campylobacter jejuni, where a microaerophilic atmosphere was obtained by using Campy Pack (Becton Dickinson, Cockeysville, MD, USA), and incubation was for 48 h. All organisms were tested with an inoculum of ≡ 10 4 cfu/spot. MICs were defined as the lower antibiotic concentration with no visible growth. Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 27853 were used as controls. The antibiotic susceptibility breakpoints (mg/L) used to define the percentage of susceptible isolates were as follows: erythromycin: 0.5 mg/L, gemifloxacin, trovafloxacin, grepafloxacin and ciprofloxacin: 1 mg/L, colistin, co-trimoxazole, ofloxacin and levofloxacin: 2 mg/L, norfloxacin, gentamicin and doxycycline: 4 mg/L, ampicillin, amoxycillin and cefotaxime: 8 mg/L, and nalidixic acid: 16 mg L. Table 45 shows the activity of gemifloxacin and the other antibiotics tested against 288 enteropathogenic bacterial strains. Fluorquinolones were very active against all microorganisms except for C. jejuni, where only 32% of strains were susceptible. Rates of non-susceptible microorganisms for nalidixic acid were 27%, 5% and 6% for Salmonella spp., Yersinia enterocolitica and Aeromonas spp. respectively. Only 1 % among 106 Salmonella spp. studied were non-susceptible to grepafloxacin (MIC = 2 mg/L). Table 46 shows MICs of quinolones studied against 6 Salmonella spp. with MICs for ciprofloxacin >0.25 mg/L. Cefotaxime was active against 100% of organisms, except for C. jejuni, where only 57% were susceptible to this antibiotic. The activity of ampicillin and amoxicillin was variable, Yersinia enterocolitica and Aeromonas spp isolates were non susceptible to these betalactams, and 43% and 77% of Shigella spp and Salmonella spp. respectively were susceptible to both antibiotics. Ampicillin was more active than amoxicillin against Hafnia alvei. Their activity against C. jejuni was similar. Gentamicin was the most active antibiotic tested, with only 4% of Salmonella spp. isolates being resistant to it. Colistin was active against Yersinia enterocolitica, Shigella spp. and Aeromonas spp. Only 32% of Salmonella isolates were susceptible to colistin and its activity was also poor against Hafnia alvei and C. jejuni. Except for Shigella spp. co-trimoxazole was very active, with only 4% of Salmonella spp. and C. jejuni being resistant to it. Doxycycline was very active against Aeromonas spp. and its activity against the other organisms tested was variable with only 40% of Campylobacter jejuni, 43 o of Shigella spp,, 22% of Salmonella spp., 22% of Hafnia alvei and 5% Yersinia enterocolitica being no susceptible to it. 77% of isolates of C. jejuni were inhibited by a concentration <0.5 mg/1 of erythromycin, but only 1 strain was highly resistant to this antibiotic (MIC = 128 mg/L). The other isolates were all inhibited by a concentration <4 mg/L of erythromycin. By weight, except for C. jejuni, gemifloxacin was the most active compound tested, 100% of isolates being inhibited by a concentration of 0.25 mg/L. Antibiotics can be useful for treating bacterial diarrhea and also to prevent illness and the spread of infections (Reves, et al., Arch. Int. Med., 148: 2421-2427 (1988)). The in vitro activity of many classical oral antibiotics against recently isolated bacterial enteropathogens is poor. Since 1988, an increase in the resistance of Salmonella spp. to classical antimicrobial such as ampicillin, chloramphenicol, tetracycline, cotrimoxazole has been described especially among S. typhimurium and S. virchow (Ramos, et al., Eur. J. Clin. Microbiol. Infect. Dis., 15: 85-88 (1996); Soriano, et al., J. Antimicrob. Chemother., 34: 157- 160 ( 1994); Threlfall, et al., Clin. Microbiol. Infect., 5: 130-134 (1999)). Data confirms this fact with rates of non-susceptible Salmonella spp. to ampicillin, doxycycline, and co- trimoxazole of 23%, 22% and 4% respectively. MICs of ciprofloxacin >0.25 mg/L against Salmonella spp. isolates are considered for some authors as being clinically significant (Threlfall, et al., Clin. Microbiol. Infect., 5: 130-134 (1999)). Six isolates of S. virchow, S. hadar, S. tshiongwe and S. newport were studied, which MICs for ciprofloxacin were >0.25 mg/L, gemifloxacin being the most active quinolone against these isolates. Many Shigella spp. are resistant to ampicillin, cotrimoxazole and doxycycline (Soriano, et al., J. Antimicrob. Chemother., 34: 157-160 (1994)) as indicated by the data, with high rates of resistance in these species to these three antibiotics. Hafnia alvei in which virulence factors similar to some phenotypes of f. coli have been described (Ismaili, et al., J. Clin. Microbiol., 34: 2973- 2979, 1997)) is usually susceptible to quinolones, newer cephalosporins, carbapenems and piperacillin. Data indicates that a quinolone, cefotaxime, gentamicin and co-trimoxazole and in a less extent doxycycline can be used in the treatment of infections caused by this microorganism. Against Aeromonas spp., data confirms (Burgos, et al., Eur. J. Clin. Microbiol. Infect. Dis., 9: 413-417 (1997)) the activity of quinolones, doxycycline, cotrimoxazole, gentamicin and cefotaxime and the ineficacy of aminopenicillins. Yersinia enterocolitica produces betalactamases that inactive some betalactams and resistance to other antibiotics has been described (Stock, et al., J. Antimicrob. Chemother., 43: 37-45 (1999); Stolk-Engelaar, et al., J. Antimicrob. Chemother., 36: 839-843 (1995)). The antibiotics tested, except aminopenicillins, were very active against this microorganism. High rates of resistance among C. jejuni strains are being described to quinolones (Aarestrup, et al., Antimicrob. Agents Chemother., 41 : 2244-2250 (1997); Sjogren, et al., J. Antimicrob. Chemother., 40: 257-261 (1997); Soriano, et al., J. Antimicrob. Chemother., 34: 157-160 (1994)) but erythromycin and other macrolides are active against this microorganim. The data shows this increase in quinolone resistance in C. jejuni in comparison with isolates from 1996 (Soriano, et al, J. Antimicrob. Chemother., 34: 157-160 (1994)). In contrast only 1 strain of C. jejuni showed a high resitance to erythromycin. A quinolone can be used to treat a gastrointestinal infection when indicated. For C. jejuni, another antibiotic such as erythromycin must be considered. Gemifloxacin is a new quinolone with a good in vitro activity against important gastrointestinal pathogens and could be a good election in these infections. These results must be assessed in the context of in vivo trials before the clinical role of this new fluoroquinolone can be determined. Table 45. In vitro activity of gemifloxacin and 14* other antibiotics against enteropathogenic bacterial strains. MIC (mg/L) Range 50% 90% % Susceptible Salmonella spp. N= 106 Gemifloxacin (SB 265805) ≤O.015-0.25 0.03 0.12 100 Trovafloxacin <0.015-1 0.06 0.25 100 Grepafloxacin 0.03-2 0.06 0.25 99 Ciprofloxacin <0.015-1 0.03 0.12 100 Ofloxacin 0.06-2 0.12 0.5 100 Norfloxacin 0.06-4 0.06 0.5 100 Levofloxacin 0.06-1 0.06 0.25 100 Nalidixic acid 2->128 4 >128 73 Ampicillin 1->128 4 >128 77 Amoxicillin 1->128 1 >128 77 Cefotaxime 0.06-0.5 0.12 0.12 100 Gentamicin 0.12-128 0.25 0.5 96 Colistin 0.5->128 8 8 32 Doxycycline 1-128 2 16 78 Co-trimoxazole <0.015->128 0.06 0.12 96 Hafnia alvei N= 32 Gemifloxacin (SB 265805) ≤O.015-0.06 0.03 0.03 100 Trovafloxacin 0.03-0.12 0.06 0.06 100 Grepafloxacin ≤O.015-0.06 0.03 0.06 100 Ciprofloxacin <0.015 <0.015 <0.015 100 Ofloxacin 0.03 0.03 0.03 100 Norfloxacin <0.015-0.03 0.03 0.03 100 Levofloxacin ≤O.015-0.03 0.03 0.03 100 Nalidixic acid 1-2 2 2 100 Ampicillin 2-64 16 64 14 Amoxicillin 16-128 64 64 0 Cefotaxime 0.12-0.5 0.25 0.5 100 Gentamicin 0.25-0.5 0.25 0.5 100 Colistin 0.5-16 8 16 6 Doxycycline 1-16 2 8 78 Co-trimoxazole 0.03-0.5 0.25 0.25 100 Yersinia enterocolitica N= 22 Gemifloxacin (SB 265805) <0.015-0.12 0.03 0.03 100 Trovafloxacin <0.015-0.25 0.06 0.06 100 Grepafloxacin <0.015-0.25 0.03 0.03 100 Ciprofloxacin <0.015-0.25 0.03 0.03 100 Ofloxacin 0.03-0.5 0.12 0.12 100 Norfloxacin 0.06-0.5 0.06 0.06 100 Levofloxacin 0.03-0.5 0.06 0.06 100 Nalidixic acid 0.5->128 2 2 95 Ampicillin 32-64 32 64 0 Amoxicillin 128 128 128 0 Cefotaxime 0.06-0.12 0.06 0.06 100 Gentamicin 0.5-1 1 1 100 Colistin 0.5-1 1 1 100 Doxycycline 0.25-8 1 2 95 Co-trimoxazole 0.06-1 0.12 1 100 Shigella spp. N= 21 Gemifloxacin (SB 265805) <0.015 <0.015 <0.015 100 Trovafloxacin <0.015 <0.015 <0.015 100 Grepafloxacin ≤O.015-0.03 <0.015 0.03 100 Ciprofloxacin <0.015 <0.015 <0.015 100 Ofloxacin <0.015-0.06 0.03 0.06 100 Norfloxacin 0.03-0.06 0.06 0.06 100 Levofloxacin ≤O.015-0.03 0.03 0.03 100 Nalidixic acid 1-2 1 2 100 Ampicillin 2->128 64 >128 43 Amoxicillin 4->128 128 >128 43 Cefotaxime ≤O.015-0.03 <0.015 0.03 100 Gentamicin 0.5-1 1 1 100 Colistin 0.25 0.25 0.25 100 Doxycycline 0.5-32 16 32 43 Co-trimoxazole 0.03->128 0.06 >128 11 Aeromonas spp. N= 16 Gemifloxacin (SB 265805) <0.015-0.12 <0.015 0.03 100 Trovafloxacin ≤O.015-0.25 <0.015 0.03 100 Grepafloxacin <0.015-0.12 0.03 0.06 100 Ciprofloxacin ≤O.015-0.06 <0.015 <0.015 100 Ofloxacin ≤0.015-0.12 <0.015 0.03 100 Norfloxacin <0.015-0.12 <0.015 0.03 100 Levofloxacin <0.015-0.06 <0.015 <0.015 100 Nalidixic acid 0.06->128 0.12 0.25 94 Ampicillin 16->128 >128 >128 0 Amoxicillin 64->128 >128 >128 0 Cefotaxime <0.015-0.12 0.03 0.12 100 Gentamicin 0.25-1 0.5 1 100 Colistin 0.25-32 2 4 81 Doxycycline 0.25-4 0.5 2 100 Co-trimoxazole 0.06-2 0.25 0.25 100 Campylobacter jejuni N= 91 Gemifloxacin (SB 265805) 0.03-128 32 128 32 Trovafloxacin <0.015-32 8 8 32 Grepafloxacin 0.03-128 32 64 32 Ciprofloxacin 0.06-128 16 64 32 Ofloxacin 0.06->128 16 32 32 Norfloxacin 0.12->128 128 >128 32 Levofloxacin 0.06-128 8 32 32 Nalidixic acid 2->128 >128 >128 31 Ampicillin 0.25->128 8 32 67 Amoxicillin 0.12->128 4 32 69 Cefotaxime 2-32 8 16 57 Gentamicin 0.12-1 0.25 0.5 100 Colistin 1-32 4 8 3 Doxycycline 0.06-64 16 32 40 Co-trimoxazole 0.25->128 1 2 96 Erythromycin 0.12-128 0.5 1 77 *15 antibiotics for C. jejuni. Table 46. MICs of quinolones tested against 6 Salmonella spp in which MICs for ciprofloxacin were >0.25 mg/L. MIC (mg/L) S. virchow(2) S. hadar(2) S. tshiongwe(l) S. newport(l) Gemifloxacin 0.12 0.25 0.25 0.25 Trovafloxacin 0.25 0.5 1 0.5 Grepafloxacin 0.25 1 2 1 Ciprofloxacin 0.25 0.5 1 0.5 Ofloxacin 0.5 2 2 2 Norfloxacin 0.5 4 4 2 Levofloxacin 0.25 1 1 1 Nalidixic acid >128 >128 >128 >128 The invention provides a method for modulating metabolism of enteropathogenic bacteria. Skilled artisans can readily choose enteropathogenic bacteria or patients infected with or suspected to be infected with these organisms to practice the methods of the invention. Alternatively, the bacteria useful in the methods of the invention may be those described herein. While a preferred object of the invention provides a method wherein said enteropathogenic bacteria is selected from the group consisting of: Salmonella spp. (including S. enteritidis, S. typhimurium, S. virchow, S. tshiongwe, S. newport, S. ohio, S. hadar, and S. georgia), Hafnia alvei, Yersinia enterocolitica, Shigella spp. (including S. sonnei, S. flexneri, and S. boydii), Aeromonas spp. (including A. hydrophila and A. sobria), and Campylobacter jejuni. The contacting step in any of the methods of the invention may be performed in many ways that will be readily apparent to the skilled artisan. However, it is preferred that the contacting step is a provision of a composition comprising a gemifloxacin compound to a human patient in need of such composition or directly to bacteria in culture medium or buffer. For example, when contacting a human patient or contacting said bacteria in a human patient or in vitro, the compositions comprising a quinolone, particularly a gemifloxacin compound, preferably pharmaceutical compositions may be administered in any effective, convenient manner including, for instance, administration by topical, oral, anal, vaginal, intravenous, intraperitoneal, intramuscular, subcutaneous, intranasal or intradermal routes among others. It is also preferred that these compositions be employed in combination with a non- sterile or sterile carrier or carriers for use with cells, tissues or organisms, such as a pharmaceutical carrier suitable for administration to a subject. Such compositions comprise, for instance, a media additive or a therapeutically effective amount of a compound of the invention, a quinolone, preferably a gemifloxacin compound, and a pharmaceutically acceptable carrier or excipient. Such carriers may include, but are not limited to, saline, buffered saline, dextrose, water, glycerol, ethanol and combinations thereof. The formulation should suit the mode of administration. Quinolone compounds, particularly gemifloxacin compounds and compostions of the methods of the invention may be employed alone or in conjunction with other compounds, such as bacterial efflux pump inhibtor compounds or antibiotic compounds, particularly non- quinolone compounds, e.g., beta-lactam antibiotic compounds. In therapy or as a prophylactic, the active agent of a method of the invention is preferably administered to an individual as an injectable composition, for example as a sterile aqueous dispersion, preferably an isotonic one. Alternatively, the gemifloxacin compounds or compositions in the methods of the invention may be formulated for topical application for example in the form of ointments, creams, lotions, eye ointments, eye drops, ear drops, mouthwash, impregnated dressings and sutures and aerosols, and may contain appropriate conventional additives, including, for example, preservatives, solvents to assist drug penetration, and emollients in ointments and creams. Such topical formulations may also contain compatible conventional carriers, for example cream or ointment bases, and ethanol or oleyl alcohol for lotions. Such carriers may constitute from about 1% to about 98% by weight of the formulation; more usually they will constitute up to about 80% by weight of the formulation. For administration to mammals, and particularly humans, it is expected that the antibacterially effective amount is a daily dosage level of the active agent from 0.001 mg/kg to 10 mg/kg, typically around 0.1 mg/kg to 1 mg/kg, preferably about 1 mg/kg. A physician, in any event, will determine an actual dosage that is most suitable for an individual and will vary with the age, weight and response of the particular individual. The above dosages are exemplary of the average case. There can, of course, be individual instances where higher or lower dosage ranges are merited, and such are within the scope of this invention. It is preferred that the dosage is selected to modulate metabolism of the bacteria in such a way as to inhibit or stop growth of said bacteria or by killing said bacteria. The skilled artisan may identify this amount as provided herein as well as using other methods known in the art, e.g. by the application MIC tests. A further embodiment of the invention provides for the contacting step of the methods to further comprise contacting an in-dwelling device in a patient. In-dwelling devices include, but are not limited to, surgical implants, prosthetic devices and catheters, i.e., devices that are introduced to the body of an individual and remain in position for an extended time. Such devices include, for example, artificial joints, heart valves, pacemakers, vascular grafts, vascular catheters, cerebrospinal fluid shunts, urinary catheters, and continuous ambulatory peritoneal dialysis (CAPD) catheters. A quinolone, particularly a gemifloxacin compound or composition of the invention may be administered by injection to achieve a systemic effect against bacteria of the invention, shortly before insertion of an in-dwelling device. Treatment may be continued after surgery during the in-body time of the device. In addition, the composition could also be used to broaden perioperative cover for any surgical technique to prevent bacterial wound infections caused by or related to bacteria. In addition to the therapy described above, a gemifloxacin compound or composition used in the methods of this invention may be used generally as a wound treatment agent to prevent adhesion of bacteria to matrix proteins, particularly enteropathogenic bacteria, exposed in wound tissue and for prophylactic use in dental treatment as an alternative to, or in conjunction with, antibiotic prophylaxis. Alternatively, a quinolone, particularly a gemifloxacin compound or composition of the invention may be used to bathe an indwelling device immediately before insertion. The active agent will preferably be present at a concentration of 1 μg/ml to lOmg/ml for bathing of wounds or indwelling devices. Other bacteria may also be included in the methods of th invention. The skilled artisan may identify these organisms as provided herein as well as using other methods known in the art, e.g. MIC tests. Also provided by the invention is a method of treating or preventing a bacterial infection by enteropathogenic bacteria comprising the step of administering an antibacterially effective amount of a composition comprising a quinolone, particularly a gemifloxacin compound to a mammal, preferably a human, suspected of having or being at risk of having a bacterial infection. Preferred embodiments of the invention include, among other things, methods wherein said composition comprises gemifloxacin, or a pharmaceutically acceptable derivative thereof. All studies provided herein were carried out using standard techniques, which are well known and routine to those of skill in the art, except where otherwise described in detail. All parts or amounts set out in the following examples are by weight, unless otherwise specified. Each reference cited herein is hereby incoφorated by reference in its entirety. Moreover, each patent application to which this application claims priority is hereby incorporated by reference in its entirety.

Claims: What is claimed is: 1. A method for modulating metabolism of respiratory tract pathogenic bacteria comprising contacting respiratory tract pathogenic bacteria with an antibacterially effective amount of a composition comprising a gemifloxacin compound, or antibacterially effective derivatives thereof. 2. The method of claim 1 wherein said respiratory tract pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Klebsiella pneumoniae. 3. A method of treating or preventing a bacterial infection by respiratory tract pathogenic bacteria comprising administering an antibacterially effective amount of a composition comprising a gemifloxacin compound to a mammal suspected of having or being at risk of having an infection with respiratory tract pathogenic bacteria. 4. The method of claim 3 wherein said respiratory tract pathogenic bacteria is selected from the group consisting of: Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and Klebsiella pneumoniae. 5. The method of claim 3 wherein said mammal is a human. 6. The method of claim 1 wherein said modulating metabolism is inhibiting growth of said bacteria. 7. The method of claim 1 wherein said modulating metabolism is killing said bacteria. 8. The method of claim 1 wherein said contacting said bacteria comprises the further step of introducing said composition into a mammal. 9. The method of claim 8 wherein said mammal is a human. 10. The method of claim 1 wherein said bacteria is selected from the group consisting of: Haemophilus influenzae, Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, and Klebsiella pneumoniae. 11. The method of claim 1 wherein said bacteria is selected from the group consisting of: Haemophilus influenzae, Streptococcus pyogenes, and Streptococcus pneumoniae.

Inventors: ALCALA LUIS, ANTONNAIDOU ANASTASIA, ATHANASIOU KALOMIRA, BOUROUSI MARIA, BOUZA EMILIO, BYGATE ELIZABETH, CABRIA FROILAN, CERCENADO EMILIA, DEBBIA EUGENIO, DIAZ MARIA DEL SOL, DOLCINO MARZIA, ESTABAN JAIME, FAIRLESS AMANDA J, FERNANDEZ-ROBLAS RICARDO, FINLAY JANE, FURUYA NOBIHOKO, GARROTE FERNANDO GARCIA, GIANNAKOU PARASKEVI, GIMARELLOU HELEN, GONZALES-ABAD MARIA JOSE, GREKA PANAYOTA, HAMMER HEIKO, INOUE MATSUHISA, KATO KAORI, KATSALA DEMETRA, KINZIG-SCHIPPERS MARTINA, LOPEZ HORACIO, LOPEZ JUAN CARLOS, MAKINO MICHIKO, MANDARAKA AIKATERINI, MARCHESE ANNA, MARIN MERCEDES, MARTINEZ-SANCHEZ LUCIA, MARTIN-PEDROVIEJO JESUS, MATSUMOTO TETSUYA, MIKAELIAN GABRIELA, MIYAZAKA SCHUICHI, NABER CHRISTOPH K, NABER KURT G, OGASAWARA AKIRA, OHNO AKIRA, OKAMOTO RYOICHI, RUIZ-SERRANO MARIA JESUS, SARACHIAN BEATRIZ, SCARANO SILVIA, SCHITO GIAN CARLO, SORGEL FRITZ, SORIANO FRANCISCO, SOULI MARIA, STEPANIK DEBORAH, SUCARI ADRIANA, TANAKA KAORI, TONOLI ELISABETTA, VILCHES VIVIANA, WATANABE KUNITOMO, YAMAGUCHI KEIZO, ALCALA, LUIS, ANTONNAIDOU, ANASTASIA, ATHANASIOU, KALOMIRA, BOUROUSI, MARIA, BOUZA, EMILIO, BYGATE, ELIZABETH, CABRIA, FROILAN, CERCENADO, EMILIA, DEBBIA, EUGENIO, DIAZ, MARIA DEL SOL, DOLCINO, MARZIA, ESTABAN, JAIME, FAIRLESS, AMANDA J, FERNANDEZ-ROBLAS, RICARDO, FINLAY, JANE, FURUYA, NOBIHOKO, GARROTE, FERNANDO GARCIA, GIANNAKOU, PARASKEVI, GIMARELLOU, HELEN, GONZALES-ABAD, MARIA JOSE, GREKA, PANAYOTA, HAMMER, HEIKO, INOUE, MATSUHISA, KATO, KAORI, KATSALA, DEMETRA, KINZIG-SCHIPPERS, MARTINA, LOPEZ, HORACIO, LOPEZ, JUAN CARLOS, MAKINO, MICHIKO, MANDARAKA, AIKATERINI, MARCHESE, ANNA, MARIN, MERCEDES, MARTINEZ-SANCHEZ, LUCIA, MARTIN-PEDROVIEJO, JESUS, MATSUMOTO, TETSUYA, MIKAELIAN, GABRIELA, MIYAZAKA, SCHUICHI, NABER, CHRISTOPH K, NABER, KURT G, OGASAWARA, AKIRA, OHNO, AKIRA, OKAMOTO, RYOICHI, RUIZ-SERRANO, MARIA JESUS, SARACHIAN, BEATRIZ, SCARANO, SILVIA, SCHITO, GIAN CARLO, SORGEL, FRITZ, SORIANO, FRANCISCO, SOULI, MARIA, STEPANIK, DEBORAH, SUCARI, ADRIANA, TANAKA, KAORI, TONOLI, ELISABETTA, VILCHES, VIVIANA, WATANABE, KUNITOMO, YAMAGUCHI, KEIZO
Applicants: SMITHKLINE BEECHAM CORP, SMITHKLINE BEECHAM PLC, SMITHKLINE BEECHAM CORPORATION, SMITHKLINE BEECHAM P.L.C.
Application year: 2000
Main classification: A61K31
IPC codes: A61K31