NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION

Abstract: New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1) wherein X is N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; R1 is OSO2CF3, OSO2CH3, SOR5, SO2R5, COR5, CN, NO2, CONHR5, CF3, 3-thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl, Br, or I; R2 is a C1-C4 alkyl, an allyl, CH2SCH3, CH2CH2OCH3, CH2CH2CH2F, CH2CF3, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or -(CH2)-R6; R3 and R4 are independently selected from the group consisting of H and C1-C4 alkyls, however both R3 and R4 cannot be H at the same time; R5 is C1-C3 alkyls, CF3, or N(R2)2; R6 is a C3-C6 cycloalkyl, 2-tetrahydrofurane, or 3-tetra-hydrofurane, as well as pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used are disclosed.

Description: receptor agonists, i.e. dopamine receptor ligands with some but not full intrinsic activity at dopamine receptors, are being developed to achieve an optimal degree of stimulation at dopamine receptors, avoiding excessive do- pamine receptor blockade or excessive stimulation. Compounds belonging to the class of substituted 4- (phenyl-N-alkyl) -piperazine and substituted 4- (phenyl-N- alkyl) -piperidines have been previously reported. Among these compounds, some are inactive in the CNS, some dis- play serotonergic or mixed serotonergic/dopaminergic pharmacological profiles while some are full or partial dopamine receptor agonists or antagonists with high affinity for dopamine receptors. A number of 4-phenylpiperazines and 4-phenyl- piperidine derivatives are known and described, for example Costall et al . European J. Pharm. 31, 94, (1975), Mewshaw et al . Bioorg. Med. Chem. Lett., 8, 295, (1998). The reported compounds are substituted 4-phenyl- piperazine ' s, most of them being 2-, 3- or 4 -OH phenyl substituted and displaying DA autoreceptor agonist properties . Fuller R. . et al , J. Pharmacol. Exp . Therapeut . 218, 636, (1981) disclose substituted piperazines (e.g. 1- (m-trifluoro-methylphenyl) piperazine) which reportedly act as serotonin agonists and inhibit serotonin uptake. Fuller R. W. et al , Res. Commun. Chem. Pathol . Pharmacol. 17, 551, (1977) disclose the comparative effects on the 3 , 4-dihydroxy-phenylacetic acid and Res. Commun. Chem. Pathol. Pharmacol. 29, 201, (1980) disclose the compara- tive effects on the 5-hydroxyindole acetic acid concentration in rat brain by 1- (p-chlorophenol) -piperazine . Boissier J. et al Chem Abstr. 61:10691c, disclose disubstituted piperazines. The compounds are reportedly adrenolytics, antihypertensives, potentiators of barbitu- rates, and depressants of the central nervous system. A number of different substituted piperazines have been published as ligands at 5-HT 1A receptors, for example Glennon R.A. et al J. Med. Chem., 31, 1968, (1988), Mok- rosz, J. et al Arch. Pharm. ( einheim) 328, 143-148 (1995), and van Steen B.J., J. Med. Chem., 36, 2751, (1993), Dukat M.-L., J. Med. Chem., 39, 4017, (1996). Glennon R. A. discloses, in international patent applications WO 93/00313 and WO 91/09594 various amines, among them substituted piperazines, as sigma receptor ligands. Clinical studies investigating the properties of sigma receptor ligands in schizophrenic patients have not gen- erated evidence of antipsychotic activity, or activity in any other CNS disorder. Two of the most extensively studied selective sigma receptor antagonists, BW234U (rim- cazole) and BMY14802, have both failed in clinical studies in schizophrenic patients (Borison et al , 1991, Psy- chopharmacol Bull 27(2): 103-106; Gewirtz et al , 1994, Neuropsychopharmacology 10:37-40) . Summary of the invention The object of the present invention is to provide new pharmaceutically active compounds, especially useful in treatment of disorders in the central nervous system, which do not have the disadvantages of the above described substances . In the work leading to the present invention, it was found that it is desired to provide substances with specific pharmacological properties, namely substances that have modulating effects on dopamine neurotransmission. These properties have not been described earlier, and they are not possible to obtain with the earlier known compounds. The substances according to the present invention act preferentially on dopaminergic systems in the brain, and they have effects on biochemical indices in the brain with the characteristic features of dopamine antagonists. However, the substances according to the in- vention show no, or only limited, inhibitory effects on spontaneous locomotion unlike ordinary dopamine receptor antagonists that suppress behavioral activity and induce catalepsy. The substances according to the invention may even induce a slight behavioral activation with concomitant increases in small-scale movements, e.g. stops in the center of the behavior recording arena, similar to that induced by dopaminergic agonists. The present invention thus relates to new 3 -substituted 4- (phenyl-N-alkyl) piperazines and 3-substituted 4- (phenyl-N-alkyl) piperidines in the form of free base or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and use of said compounds in therap . One subject of the invention is to provide new compounds for therapeutic use, and more precisely compounds for modulation of dopaminergic systems in the mammalian brain, including human brain. Another subject of the invention is to provide compounds with therapeutic effects after oral administration. More precisely, the present invention relates to 3- substituted 4- (phenyl-N-alkyl) -piperazine or 4- (phenyl-N- alkyl) -piperidine compounds of Formula 1: wherein: X is selected from the group consisting of N, CH, and C, however X may only be C when the compound comprises a double bond at the dotted line; Ri is selected from the group consisting of OS0 2 CF 3 , OS0 2 CH 3 , S0R 5 , S0 2 R 5 , COR 5 , CN, N0 2 , CONHR 5 , CF 3 , 3- thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl, Br, and I, wherein R 5 is as defined below; R 2 is selected from the group consisting of C1-C4 alkyls, allyls, CH 2 SCH 3 , CH 2 CH 2 OCH 3 , CH 2 CH 2 CH 2 F, CH 2 CF 3 , 3,3,3- trifluoropropyl , 4 , 4 , 4-trifluorobutyl , and -(CH 2 )-R6, wherein R 6 is as defined below; R 3 and R 4 are independently selected from the group consisting of H and C ι -C 4 alkyls, however both R 3 and R 4 can- not be H at the same time; R 5 is selected from the group consisting of C 1 -C 3 alkyls, CF 3 , and N(R 2 ) 2 , wherein R 2 is as defined above; and R 6 is selected from the group consisting of C 3 -C 6 cyclo- alkyls, 2-tetrahydrofurane, and 3-tetra-hydrofurane, and pharmaceutically acceptable salts thereof. The compounds according to the present invention possess dopamine-modulating properties and are useful in treating numerous central nervous system disorders including both psychiatric and neurological symptoms. Diseases in which compounds with modulating effects on dopaminergic systems may be beneficial are in disorders related to ageing, for preventing bradykinesia and depression and for the improvement of mental functions. They may also be used to improve cognitive functions and related emotional disturbances in neurodegenerative and developmental disorders as well as after brain damage. The compounds according to the invention can be used to improve all symptoms of psychosis, including schizophrenia and schizophreniform disorders as well as drug induced psychotic disorders. The compounds according to the invention may also be used in behavioral disorders usually first diagnosed in infancy, childhood, or adolescence as well as in impulse control disorders. Also, speech disorders such as stuttering may improve. They may also be used for treating substance abuse disorders as well as disorders characterized by misuse of food. Mood and anxiety disorders, personality disorders, and conversion hysteria may also be treated with the compounds according to the invention. Neurological indications include the treatment of Huntington's disease and other movement disorders as well as movement disorders induced by drugs. Restless legs and Ti -H β CJ β X! 0 β Cn (ti -H -H β β XI 4-1 4H -H β CJ Cn SH -H (ti CJ β 4-1 -H 0 CQ 4-1 CD Cn rH -H β X! SH CD ε XI H CD X! CD β XI -H CQ J SH ε Ti 0 0 rβ β H -H 4-1 a β β > -H 0 0 CD rti > Ti a β XI -H ε CD 4-1 β 0 β X) CJ 0 J -H rβ rti H SH CQ β SH rti CD J-J 5 X. ε a CJ 0 SH > • < CD β β 0 X 4H Λ; 0 β 4H 4H CD CQ ε β 0 0 4-1 0 SH CJ CQ SH 4H CD CQ CD 0 4H 4-1 4-1 4-1 4-1 4H υ rβ rti β CO CD 4-1 rH CD 4H CQ β SH CD 4H TS CD Λ! 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This is exemplified by cis- 4- (3-methanesulfonyl-phenyl) -2 , 6-dimethyl -1-propyl- piperazine, which is the compound of Example 3, which increases 3 , 4-dihydroxy-phenylacetic acid in the striatum from 1247±65 (for controls) to 3140 ± 169 ng/g tissue at 100 μmol/kg s.c., p < 0.05, n=4. This increase in dopamine turnover is accompanied by an increase in motor activity from 27 ± 11 cm/30 min (for the controls) , to 253 ± 73 cm/30 min p < 0.05, n=4 , at 100 μmol/kg, 30-60 min post injection. Surprisingly, although cis-4- (3-methanesulfonyl-phenyl) -2 , 6-dimethyl -1-propyl -piperazine is stimulant in itself it reduces d-amphetamine induced hy- peractivity from 21140 ± 4656 cm/60 min to 2492 ± 530 cm/60min, p < 0.05, n = 4, at 100 μmol/kg s.c. Furthermore, it is important that both R3 and R4 are not H at the same time. This is further exemplified by cis-2 , 6-dimethyl -1-propyl -4- (3-trifluoro-methyl -phenyl) - piperazine, which is the compound of Example 2. Similar to cis-4- (3-methanesulfonyl-phenyl) -2 , 6-dimethyl-l- propyl-piperazine, which is the compound of Example 3, cis-2 , 6-dimethyl -1-propyl -4- (3-trifluoro-methyl-phenyl) - piperazine increases 3 , 4-dihydroxy-phenylacetic acid in the striatum from 996+18 (for controls) to 1388 ± 60 ng/g tissue at 100 μmol/kg s.c., p < 0.05, n=4. Furthermore, cis-2 , 6-dimethyl -1-propyl -4- (3-trifluoro-methyl-phenyl) - piperazine does not inhibit motoractivity in the behavioral assay; 3239 ± 194 cm/60 min (for the controls) to 3619 ± 483 cm/60min, p > 0.05, n = 4, at 100 μmol/kg s.c. This is very surprising since the similar substance 1- propyl-4- (3-triflouro-methyl-phenyl) -piperazine, which corresponds to cis-2 , 6-dimethyl-1-propyl -4- (3-trifluoro- methyl -phenyl) -piperazine wherein R3 and R4 have been substituted by H, does inhibit motoractivity in the behavioral assay, l-propyl-4- (3-triflouro-methyl-phenyl) - piperazine increases 3 , 4-dihydroxyphenyl -acetic acid in the striatum from 1066 + 46 (for controls) ng/g tissue to 3358 + 162 ng/g tissue at 50 μmol/kg s.c, p < 0.05, n = 4, followed by strong behavioral inhibition from 1244 ± 341 cm/60 min (for the controls) to 271 ± 137 at 50 μmol/kg s.c, p < 0.05, n = 4, thus, lacking the properties sought for in the present invention. Further, 1- propyl-4- (3-triflouro-methyl-phenyl) -piperazine reduces serotonin in the striatum from 395 ± 11 (controls) ng/g tissue to 308 ± 18 ng/g tissue at 50 μmol/kg s.c, p < 0.05, n = 4. An effect not seen for the compound of Example 2 [cis-2 , 6-dimethyl-1-propyl-4- (3-trifluoro-methyl- phenyl) -piperazine] ; 427 + 5 (controls) ng/g tissue to 419 ± 23 ng/g tissue at 100 μmol/kg s.c, p > 0.05, n = 4. cis-2 , 6-Dimethyl -1-propyl -4- (3 -trifluoro-methyl- phenyl) -piperazine thus has the propertied desired ac- cording to the present invention, whereas l-propyl-4- (3 - triflouro-methyl-phenyl) -piperazine is not a substance according to the present invention. cis-4- (3 -Methanesulfonyl-phenyl) -3 -methyl-1-propyl - piperidine, which is the compound of Example 4, has the ability to increase 3 , 4-dihydroxyphenyl -acetic acid in the striatum from 1111 ± 13 (for controls) ng/g tissue to 1884 ± 98 ng/g tissue at 100 μmol/kg s.c, p < 0.05, n = 4. Further, it increases spontaneous motoractivity in the behavioral assay; from 3275 ± 290 cm/60 min (for the con- trols) to 4948 ± 577 cm/60min, p < 0.05, n = 4, 0-60 min, at 100 μmol/kg s.c. cis-4- (3 -Methanesulfonyl-phenyl) -3- methyl-1-propyl -piperidine thus displays the properties desired according to the invention. The compounds according to the invention can thus be used to treat symptoms in e.g.: - schizophrenia and other psychotic disorders, such as catatonic, disorganized, paranoid, residual or differentiated schizophrenia; schizophreniform disorder; schizo- affective disorder; delusional disorder; brief psychotic disorder; shared psychotic disorder; psychotic disorder due to a general medical condition with delusions and/or hallucinations; - mood disorders, such as depressive disorders , e.g., dysthymic disorder or major depressive disorder; bipolar disorders, e.g., bipolar I disorder, bipolar II disorder, and cyclothymic disorder; mood disorder due to a general medical condition with depressive, and/or manic features ; and substance-induced mood disorder; - anxiety disorders, such as acute stress disorder, agoraphobia without history of panic disorder, anxiety dis- order due to general medical condition, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder with agoraphobia, panic disorder without agoraphobia, posttraumatic stress disorder, specific phobia, social phobia, and substance- induced anxiety disorder; - eating disorders, such as anorexia nervosa, bulimia nervosa, and obesitas; - sleep disorders, such as dyssomnias, e.g., breathing- related sleep disorder, circadian rhythm sleep disorder, hypersomnia, insomnia, narcolepsy, and "jet lag"; - impulse-control disorders not elsewhere classified, such as intermittent explosive disorder, kleptomania, pathological gambling, pyromania, and trichotillomania; - personality disorders, such as paranoid, schizoid or schizotypal disorder; antisocial, borderline, histrionic, and narcissistic disorder; and avoidant, dependent, obsessive-compulsive disorder; - medication-induced movement disorders, such as neuro- leptic induced parkinsonism, neuroleptic malignant syndrome, neuroleptic induced acute and tardive dystonia, neuroleptic induced akathisia, neuroleptic induced tar- dive dyskinesia, medication induced tremor, and medication induced dyskinesias ; - substance-related disorders, such as abuse, dependence, anxiety disorder, intoxication, intoxication delirium, psychotic disorder, psychotic disorder with delusions, mood disorder, persisting amnestic disorder, persisting dementia, persisting perception disorder, sexual dysfunction, sleep disorder, withdrawal, and withdrawal delirium due to use ore misuse of alcohol, amphetamine (or amphetamine-like substances), caffeine, cannabis, cocaine, hallucinogens, inhalants, nicotine, opioids, phencycli- dine (or phencyclidine-like substances) , sedative substances, hypnotic substances, and/or anxiolytic substances; - disorders usually first diagnosed in infancy, child- hood, or adolescence, such as mental retardation; learning disorders; motor skills disorders, e.g. developmental coordination disorder; communication disorders, e.g. expressive language disorder, phonological disorder, receptive-expressive language disorder and stuttering ; pervasive developmental disorders, e.g. Asperger's disorder, autistic disorder, childhood disintegrative disorder, and Rett ' s disorder; attention-deficit and disruptive behavior disorders, e.g. attention- deficit/hyperactivity disorder, conduct disorder, and op- positional defiant disorder; feeding and eating disorders of infancy or early childhood, e.g. feeding disorder of infancy or early childhood, pica, rumination disorder; tic disorders, e.g. chronic motor or vocal tic disorder, and Tourette's disorder; other disorders of infancy, childhood, or adolescence, e.g. selective mutism, and stereotypic movement disorder; - delirium, dementia, amnestic and other cognitive disorders, such as Alzheimer's, Creutzfeldt-Jakob disease, dead trauma, Huntington's disease, HIV disease, Pick's disease, and diffuse Lewy body dementia; - conversion hysteria; - conditions connected to normal aging, such as disturbances in motor functions and mental functions; - Parkinson's Disease and related disorders, such as multiple system atrophies, e.g. striatonigral degeneration, olivopontocerebellar atrophy, and shydrager syndrome; progressive supranuclear palsy; corticobasal degeneration; and vascular parkinsonism; - tremors, such as essential, orthostatic, rest, cerebel- lar, and secondary tremor - headaches, such as migraine, cluster headache, tension type headache, and paroxysmal headache; - movement disorders, such as dyskinesias, e.g. in deneral medicine condition, secondary to trauma or vascular insult, hemiballism, athetosis, Sydenham' s chorea, and paroxysmal; dystonias; Ekbom' s syndrome (restless legs); Wilson's Disease; Hallerworden-Spatz disease; - rehabilitation medicine, e.g. to improve rehabilitation after vascular or traumatic brain injury; - pain in conditions characterized by increased muscular tone, such as fibromyalgia, myofascial syndrome, dysto- nia, and parkinsonism; as well as - conditions related to the above that fall within the larger categories but does not meet the criteria of any specific disorder within those categories. Synthesis The synthesis of the present compounds is carried out by methods that are conventional for the synthesis of related known compounds . The syntheses of compounds in Formula 1, in general, comprise the reaction of an intermediate that supplies the alkyl group with an intermedi- ate piperidine or piperazine that supplies the amine group of Formula 2 : A convenient method of synthesis of the present compounds is by use of an alkyl iodide (e.g. 1-propyl - iodide) . Alternatively, other leaving groups besides iodide may be used on the alkyl group, of course, such as sulfonates, particularly methanesulfonate or toluenesul- fonate, bromo and the like. The alkyl intermediate is reacted with the appropriate amine in the presence of any convenient acid scavenger. The usual bases such as alkali metal or alkaline earth metal carbonates, bicarbonates and hydroxides are useful acid scavengers, as are some organic bases such as trialkylamines and trialkano- lamines. The reaction medium for such reactions may be any convenient organic solvent which is inert to the basic conditions; acetonitrile , esters such as ethyl- acetate and the like and halogenated alkane solvents are useful. Usually the reactions will be carried out at elevated temperatures such as from ambient temperature to the reflux temperature of the reaction mixture, particularly from 50°C to about 100°C. Another convenient method of synthesis of the pres- ent compounds involves reductive amination with an amine of Formula 2 : with an aldehyde or ketone, either in the presence of a reducing agent such as sodium cyanoborohydride or sodium triacetoxyborohydride or followed by reduction, e.g. using catalytic hydrogenation, to give a corresponding com- pound of Formula 1. Compounds of Fomula 3 wherein X=N is accomplished by reacting compounds of For- mula 4: with compounds of Formula 5 where Z is a leaving group like iodide. Other leaving groups besides iodide may be used on the alkyl group, of course, such as sulfonates, particularly methanesulfonate or toluenesulfonate, bromo and the like. The alkyl inter- mediate is reacted with the appropriate amine in the presence of any convenient acid scavenger. The usual bases such as alkali metal or alkaline earth metal carbonates, bicarbonates and hydroxides are useful acid scavengers, as are some organic bases such as trialkyla- mines and trialkanolamines . The reaction is performed in a suitable solvent such as n-butanol by heating at about 50-150°C. Compounds of the Formula 1 wherein X = N is also accomplished by reacting compounds of Formula 6: with an aryl substituted with a leaving group of Formula 7: where Z is halide e.g. chloro, bromo, iodo, or sulfonate e.g. -OS0 2 CF 3 , or -OS0 2 F, in the presence of a base and a zerovalent transition metal catalyst such as Pd or Ni , according to known method (Tetrahedron Letters, vol 37, 1996, 4463-4466, J. Org . Chem., vol. 61, 1996, 1133- 1135) . The catalyst, preferably Pd will have the ability to form ligand complex and undergo oxidative addition. Typical Pd catalysts will be Pd (dba) 3 (wherein dba refers to di-benzylidene acetone), Pd(PPh 3 ) 4 , Pd(OAc) 2 , or PdCl 2 [P (o-tol) 3 ] 2 and typical phosphine ligands will be BINAP, P (o-tol) 3 , dppf , or the like. The usual bases such as alkali metal or alkaline earth metal carbonates, bi- carbonates and alkyloxides are useful acid scavengers, as are some organic bases such as trialkylamines and trial - kanolamines. The reaction medium for such reactions may be any convenient organic solvents, which are inert to the basic conditions; acetonitrile , toluene, dioxane, NMP (N-methyl-2-pyrrolidone) , DME (dimethoxyethane) , DMF (N,N-dimethylformamide) , DMSO (dimethylsulfoxide) and THF (tetrahydrofuran) solvents are useful. Usually the reac- tions will be carried out at elevated temperatures such as from ambient temperature to the reflux temperature of the reaction mixture, particularly from 50 °C to about 120°C. Compounds of the Formula 1 wherein X = N is also accomplished by reacting compounds of Formula 6 with an aryl substituted with a leaving group (e.g. F or Cl) via nucleophilic aromatic displacement reactions in the presence of a base as explained above. Compounds of the Formula 1 wherein X = CH is also accomplished by transition metal catalyzed cross-coupling reaction, known as, for example, Suzuki and Stille reactions, to those skilled in the art. The reaction may be carried out between compounds of Formula 8 : wherein Y is, for example, a dialkylborane, dialkenylbo- rane or boronic acid (e.g. BEt 2 , B(0H) 2 ) or a trialkyltin (e.g. SnMe 3 , SnBu3), and an aryl substituted with a leaving group of Formula 7 : (for definition of Z, see above) in the presence of a base and a zerovalent transition metal catalyst such as Pd or Ni, according to known methods (Chem. Pharm. Bull., vol 33, 1985, 4755-4763, J. Am. Chem. Soc , vol. 109, 1987, 5478-5486., Tetrahedron Lett . , vol. 33, 1992, 2199- 2202) . In addition, Y can also be a zink- or magnesium- halide group (e.g. ZnCl 2 , ZnBr 2 , Znl 2 , MgBr 2 , Mgl 2 ) according to known methods (Tetrahedron Lett., vol. 33, 1992, 5373-5374, Tetrahedron Lett., vol. 37, 1996, 5491-5494). The catalyst, preferably Pd will have the ability to form ligand complex and undergo oxidative addition. The definition of ligands, bases and solvents, is mentioned above . Alternatively, the transition metal catalyzed cross- coupling reaction can be performed with the opposite sub- stitution pattern: with an heteroaryl/alkenyl substituted with an leaving group of Formula 10: in the presence of a base and a zerovalent transition metal catalyst such as Pd or Ni, according known methods discussed in the previous paragraph. Compounds of Formula 11: can be prepared by catalytic hydrogenation of the tetra- hydropyridine or pyridine from the previous paragraph, using standard methods known in the art, generally with palladium on carbon, Pt0 2 , or Raney nickel as the catalyst. The reaction is performed in an inert solvent, such as ethanol or ethyl acetate, either with or without a protic acid, such as acetic acid or HCl . When the p ri- dine ring is quaternized with an alkyl group the ring can be partly reduced by NaBH 4 or NaCNBH 4 , yielding the tetra- hydropyridine analog which can further be reduced with catalytic hydrogenation. Another convenient method of syntheses of compounds of the Formula 1, wherein X = CH is also accomplished by treating arylhalides of Formula 7 : wherein Z is Cl , Br, or I, with alkyllithium reagents, for example, butyllithium, sec-butyllithium or tert- butyllithium, preferably butyllitium or Mg (grignard reaction) in an inert solvent. Suitable solvents include, for example ether or tetrahydrofuran, preferably tetrahy- drofuran. Reaction temperatures range from about -110°C to about 60°C. The intermediate lithium anions or magne- sium anions thus formed may then be further reacted with a suitable electrophile of Formula 12 : wherein A is defined as a protecting group like t-Boc (tert-butoxycarbonyl) , Fmoc (fluorenylmethoxycarbonyl) , Cbz (benzyloxycarbonyl) or a an alkylgroup like benzyl. The intermediates of Formula 13 : which are formed require that the hydroxy group be removed so as to result in compounds of Formula 1 (X=CH) , This step may be accomplished by one of several standard methods known in the art. For example, a thio- carbonyl derivative (for example a xanthate) may be prepared and removed by a free radical process, of which are known to those skilled in the art. Alternatively, the hy- droxyl group may be removed by reduction with a hydride source such as triethylsilane under acidic conditions, using such as, for example, trifluoroacetic acid or boron trifluoride. The reduction reaction can be performed neat or in a solvent, such as methylene chloride. A further alternative would be to first convert the hydroxyl group to a suitable leaving group, such as tosylate or chloride, using standard methods. The leaving group is then removed with a nucleophilic hydride, such as, for example, lithium aluminium hydride. This last reaction is performed typically in an inert solvent, such as, ether or tetrahydrofuran. Another alternative method for removing the hydroxyl group is to first dehydrate the alcohol to an olefin with a reagent such as Burgess salt (J. Org . Chem., vol 38, 1973, 26) followed by catalytic hydrogenation of the dou- ble bond under standard conditions with a catalyst such as palladium on carbon. The alcohol may also be dehydrated to the olefin by treatment with acid such as p- toluenesulfonic acid or trifluoroacetic acid. The protecting group, A, is removed under standard conditions known by those skilled in the art. For example, t-Boc cleavages are conveniently carried out with trifluoroacetic acid either neat or in combination with methylene chloride. F-moc is conveniently cleaved off with simple bases such as, ammonia, piperidine, or mor- pholine, usually in polar solvents such as DMF and aceto- nitrile. When A is Cbz or benzyl, these are conveniently cleaved off under catalytic hydrogenation conditions. The benzyl group can also be cleaved off under N-dealkylation conditions such as treatment with a-chloroethyl chloro- formate (J. Org. Chem., vol 49, 1984, 2081-2082). It is further possible to convert a radical Ri in a compound of the Formula 1 into another radical RI , e.g. by oxidizing methylsulfide to methylsulfone (for example by m-chloroperoxybenzoic acid) , substitution of a triflate or halide group with a cyano group (for example palladium catalyzed cyanation) , substitution of triflate or halide group with a ketone (for example palladium catalyzed Heck reaction with butyl vinyl ether) , substitution of a triflate or halide group with a carboxamide (for example, palladium catalyzed carbonylation) , or cleaving an ether by, for example, converting a methoxy group into the corresponding hydroxyl derivate, which can further be converted into the corresponding mesylate or triflate. The terms mesylate and triflate refers to OS0 2 CH 3 , CH 3 S0 3 or OS0 2 CF 3 , CF 3 S0 3 , respectively. In summary, the general process for preparing the present compounds has six main variations, which may briefly be described as follows: according to Scheme 1 : or according to Scheme 2 : o Reducing agent (Y independently H X = N , CH or C or small alkyl groups) X = N , CH or C or according to Scheme 3 : or according to Scheme 4 "Pd"-catalyst (Z is a leaving group) or according to Scheme 5 "Pd"-catalyst Catalytic hydrogenation (Z is a leaving group Y is Zn, Mg, B(alkyl) 2 , B(OH) 2 , or Sn(alkyl) 3 ) or according to Scheme 6 dehydration cleavage of A As used herein the term Cι-C 4 alkyl refers to an alkyl containing 1-4 carbon atoms in any isomeric form. The various carbon moieties are defined as follows: Alkyl refers to an aliphatic hydrocarbon radical and includes branched or unbranched forms such as methyl , ethyl , n- propyl, i-propyl, n-butyl, i -butyl, s-butyl, t -butyl. The term cycloalkyl refers to a radical of a saturated cyclic hydrocarbon such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl . The term "patient" used herein refers to an individ- ual in need of the treatment according to the invention. The term "treatment" used herein relates to both treatment in order to cure or alleviate a disease or a condition, and to treatment in order to prevent the development of a disease or a condition. The treatment may either be performed in an acute or in a chronic way. Both organic and inorganic acids can be employed to form non-toxic pharmaceutically acceptable acid addition salts of the compounds according to the invention. Illustrative acids are sulfuric, nitric, phosphoric, hydro- chloric, citric, acetic, lactic, tartaric, palmoic, ethane disulfonic, sulfamic, succinic, cyclohexylsulfamic, fumaric, maleic, and benzoic acid. These salts are readily prepared by methods known in the art. The pharmaceutical composition containing a compound according to the invention may also comprise substances used to facilitate the production of the pharmaceutical preparation or the administration of the preparations. Such substances are well known to people skilled in the art and may for example be pharmaceutically acceptable adjuvants, carriers and preservatives. In clinical practice the compounds used according to the present invention will normally be administered orally, rectally, or by injection, in the form of pharmaceutical preparations comprising the active ingredient either as a free base or as a pharmaceutically acceptable non-toxic, acid addition salt, such as the hydrochloride, lactate, acetate, sulfamate salt, in association with a pharmaceutically acceptable carrier. The carrier may be a solid, semisolid or liquid preparation. Usually the ac- tive substance will constitute between 0.1 and 99% by weight of the preparation, more specifically between 0.5 and 20% by a weight for preparations intended for injec- tion and between 0.2 and 50% by weight for preparations suitable for oral administration. To produce pharmaceutical preparations containing the compound according to the invention in the form of dosage units for oral application, the selected compound may be mixed with a solid excipient, e.g. lactose, saccharose, sorbitol, mannitol, starches such as potato starch, corn starch or amylopectin, cellulose derivatives, a binder such as gelatine or polyvinyl- pyrrolidine, and a lubricant such as magnesium stearate, calcium stearate, polyethylene glycol , waxes, paraffin, and the like, and then compressed into tablets. If coated tablets are required, the cores, prepared as described above, may be coated with a concentrated sugar solution which may contain e.g. gum arable, gelatine, talcum, titanium dioxide, and the like. Alternatively, the tablet can be coated with a polymer known to the man skilled in the art, dissolved in a readily volatile organic solvent or mixture of organic solvents. Dyestuffs may be added to these coatings in order to readily distinguish between tablets containing different active substances or different amounts of the active compound. For the preparation of soft gelatine capsules, the active substance may be admixed with e.g. a vegetable oil or polyethylene glycol. Hard gelatine capsules may contain granules of the active substance using either the mentioned excipients for tablets e.g. lactose, saccharose, sorbitol, mannitol, starches (e.g. potato starch, corn starch or amylopectin) , cellulose derivatives or gelatine. 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X) rH U £ -H β Pπ £ QJ -H rβ 4-1 rd X! rH 0 4-1 CJ QJ β rd QJ Cn £ S 4-1 QJ β -H QJ J rd -H r 0 _- ) β 4-1 0 rd X rd SH rd rd Cn rd X! S β QJ TS 0 SH X! QJ QJ X Pi SH rd H SH -H 0 O 4-1 -H ( β -H o υ D o\° X QJ SH CQ rd υ a a X) -H X rd s rβ > 5 CQ Ti a rd X! a 4J -H SH £ X O Additionally, the present invention is also considered to include stereoisomers as well as optical isomers, e.g. mixtures of enantiomers as well as individual enan- tiomers and diastereomers, which arise as a cosequense of structural asymmetry in certain compounds of the instant series. Separation of the individual isomers is accomplished by application of various methods which are well known to practitioners in the art. The invention is further illustrated in the examples below, which in no way are intended to limit the scope of the invention. Example 1: 3- (cis-3 , 5-Dimethyl-4-propyl-piperazin-l-yl) - benzonitrile A mixture of 3-bromo-benzonitrile (0.35g), cis-2, 6- dimethyl- 1-propyl -piperazine (0.3 g) , sodium tert- butoxide (0.28 g) BINAP (25 mg) and [Pd 2 (dba) 3 (20 mg) in toluene (6 ml) was heated under argon at 80°C for 24 h. After cooling to room temperature, the reaction mixture was filtered through a pad of celite and evaporated to dryness. The crude material was purified by flash chroma- tography on silica gel using CH 2 Cl 2 :MeOH (45:1 (v/v) ) . MS m/z (relative intensity, 70 eV) 257 (M+, 38) , 242 (52) , 228 (bp) , 130 (45) 112 (74) . Example 2: cis- 2 , 6-Dimethyl- l-propyl-4 - (3 -trifluoro- methyl -phenyl) -piperazine The titled compound was prepared in a similar manner as described in Example 1 from 3 -iodobenzotrifluoride and cis-2 , 6-dimethyl-l-propyl-piperazine . The amine was converted into the HC1 salt and recrystallized from etha- nol/diethylether : m.p. 188°C MS m/z (relative intensity, 70 eV) 300 (M+, 26) , 271 (58) , 112 (bp) , 70 (73) , 56 (93) . Example 3: cis-4- (3 -Methanesulfonyl-phenyl) -2 , 6-dimethyl- 1 -propyl -piperazine The titled compound was prepared in a similar manner as described in Example 1 from 3 -bromo-methanesulfonyl benzene and cis-2 , 6-dimethyl-l-propyl-piperazine . The amine was converted into the HC1 salt and recrystallized from ethanol/diethylether: m.p. 233 °C MS m/z (relative intensity, 70 eV) 310 (M+, 24) , 281 (57) , 112 (bp) , 70 (55) 56 (59) . Example 4: cis-4- (3 -Methanesulfonyl-phenyl) -3 -methyl-1- propyl -piperidine A suspension of cis-4- (3-methanesulfonyl-phenyl) -3- methyl -piperidine (0.28 g) and ground K 2 C0 3 (300 mg) was stirred in CH 3 CN (30 mL) at room temperature. A solution of 1-iodo-propane (220 mg) in CH 3 CN (5 mL) was added dropwise. The mixture was stirred at 50 °C overnight. The reaction mixture was filtered and the volatiles were evaporated in vacuum. The oily residue was chromato- graphed on a silica column with MeOH:CH 2 Cl 2 (1:9 (v/v)) as eluent . Collection of the fractions containing pure product and evaporation of the solvent afforded pure cis-4 - (3 -Methanesulfonyl -phenyl ) -3 -methyl - 1-propyl -piperidine . The amine was converted into the HCl salt and recrystal- lized from ethanol/diethylether: m.p. 197°C MS m/z (relative intensity, 70 eV) 295 (M+, 1) , 266 (47) , 84 (bp) , 70 (49) 63 (27). 13 C-NMR (75.4 MHz, CDCl 3 ) : 11.8, 12.7, 20.0, 24.7, 34.9, 44.5, 44.8, 54.7, 60.3, 60.6, 124.8, 126.2, 129.1, 132.7, 140.6, 146.7. Example 5: cis-2 , 6-Dimethyl-l-propyl-4 - (3 -trifluoromethane-sulfonyl-phenyl) -piperazine The titled compound was prepared in a similar manner as described in Example 4 from cis-2 , 6-dimethyl-l- (3- trifluoromethane-sulfonyl-phenyl) -piperazine and iodopro- pane. MS m/z (relative intensity, 70 eV) 364 (M+, 18), 335 (79) , 112 (bp) , 70 (56) , 56 (60) . Example 6: cis-1- \3 - (3 , 5 -Dimethyl -4 -propyl-piperazin-1- yl) -phenyl1 -ethanone The titled compound was prepared in a similar manner as described in Example 4 from cis-1- [3- (3 , 5-dimethyl- piperazin-1-yl) -phenyl] -ethanone and iodopropane. MS m/z (relative intensity, 70 eV) 274 (M+, 27), 259 (32), 245 (40), 132 (35) 112 (bp) , Rf = 0.36 (CH 2 Cl 2 :MeOH 19/1). Example 7: cis-2 , 6-Dimethyl-l-ethyl-4- (3 -trifluoromethane-sulfonyl-phenyl) -piperazine The titled compound was prepared in a similar manner as described in Example 4 from cis-2 , 6-dimethyl-l- (3- trifluoromethane-sulfonyl-phenyl) -piperazine and bromo- ethane. MS m/z (relative intensity, 70 eV) 350 (M+, 17), 335 (48) , 98 (bp) , 71 (41) , 56 (76) . Example 8: cis-2 , 6-Dimethyl-l-allyl-4- (3-trifluoromethane-sulfonyl -phenyl ) -piperazine The titled compound was prepared in a similar manner as described in Example 4 from cis-2 , 6-dimethyl-l- (3- trifluoromethane-sulfonyl-phenyl) -piperazine and allyl- bromide. MS m/z (relative intensity, 70 eV) 362 (M+, 22), 110 (bp) , 83 (59) , 68 (40) , 56 (40) . Synthesis of intermediates used in the above Examples are described in the preparations below. Preparation 1: l-Benzyl-3-methyl-4- (3-methylsulfanyl- phenyl) -piperidin-4-ol 3-Bromothioanisole (3 g) dissolved in dry THF (40 ml) was added dropwise to a mixture of Mg (0.4 g) and THF under a stream of Argon (g) . The mixture was then brought to reflux for 1 h. The cloudy solution was cooled to 0°C and l-benzyl-3-methyl-4-piperidone (3 g) dissolved in dry THF (30 ml) was added dropwise. The mixture was then stirred at r.t. (30 min) and finally refluxed for lh. The reaction mixture was quenched with saturated ammonium chloride solution (30 ml) . The mixture was extracted several times with EtOAc and the combined organic phases were dried (MgS0 4 ) , filtered and evaporated to dryness. The oily residue was chromathographed on a silica column using CH 2 Cl 2 :MeOH (19:1 (v/v)) as eluent, yielded 3.12 g of l-Benzyl-3 -methyl -4- (3 -methylsulfanyl -phenyl) - piperidin-4-ol . MS m/z (rel. intensity, 70 eV) 327 (M+, 11), 160 (16), 148 (11), 91 (bp) , 65 (15). Preparation 2: 1-Benzyl -3 -methyl -4- (3 -methylsulfanyl- phenyl) -1,2,3, 6-tetrahydro-pyridine l-Benzyl-3-methyl-4- (3 -methylsulfanyl-phenyl) - piperidin-4-ol (3.12 g) was dissolved in trifluoroacetic acid (80 ml) and refluxed for 3 days. CH 2 C1 2 (100 ml) was added and the mixture was washed with two portions of 10%-Na 2 CO 3 , dried (MgS0 4 ) , filtered and evaporated to dryness (yield 1.35 g) . MS m/z (rel. intensity, 70 eV) 309 (M+, 24), 143 (35), 128 (22), 91 (bp) , 65 (23). Preparation 3: cis-l-Benzyl-3-methyl-4- (3 -methylsulfanyl-phenyl) -piperidine l-Benzyl-3-methyl-4- (3 -methylsulfanyl -phenyl) - 1 , 2 , 3 , 6-tetrahydro-pyridine (1.35 g) was dissolved in 35 ml MeOH. Solid ammonium formate (1.93 g) and Pd/C (0.25 g) were added. The mixture was refluxed under a nitrogen atmosphere for 4 h. The mixture was then filtered through a pad of Celite, and the solvent was evaporated in vacuo. The residue was redissolved in CH 2 C1 2 and purified by flash-chromathography. Yield 0.51 g of the titled compound. MS m/z (rel. intensity, 70 eV) 311 (M+, 48), 310 (32), 160 (19), 91 (bp) , 65 (15). Preparation 4: cis-l-Benzyl-4- (3-methanesulfonyl-phenyl) - 3-methyl-piperidine cis-l-Benzyl-3-methyl-4- (3 -methyl-sulfanyl -phenyl) - piperidine (0.49 g) and CF 3 C00H (0.27 g) was dissolved in CH 2 C1 2 (40 ml) and cooled to 0°C. m-Chloroperoxybenzoic acid (0.57 g) was added portions wise and the mixture was stirred at r.t over night. The resulting clear solution was washed with 10%-Na 2 CO 3 solution, dried (MgS0 4 ) , fil- tered and concentrated by evaporation and yielding an oily residue (0.5 g) . MS m/z (relative intensity, 70 eV) 343 (M+, bp) , 342 (92), 328 (17), 266 (22), 252 (85). Preparation 5: cis-4- (3 -Methanesulfonyl-phenyl) -3 -methyl - piperidine A solution of cis-l-Benzyl-4- (3-methanesulfonyl- phenyl) -3 -methyl -piperidine (0.38 g) in 1,2- dichloroethane (10 ml) was cooled to 0°C. Then α-chloro- ethyl chloroformate (1.6 g) dissolved in 1 , 2-dichloro- ethane (5 ml) was added dropvise at 0°C. The reaction mixture was then brought to reflux for 2 days. The vola- tiles were evaporated in vacuo and the residue triturated with methanol . The mixture was brought to reflux for 4 hours. The solvent was evaporated to afford the title compound as HCl salt (0.28 g) . MS m/z (relative intensity, 70 eV) 253 (M+, 15), 115 (28), 70 (65), 57 (bp) , 56 (86) . Preparation 6: cis-2 , 6-dimethyl-l- (3-trifluoromethane- sulfonyl-phenyl) -piperazine The titled compound was prepared in a similar manner as described in Example 1 from 3-bromo-trifluoromethan- sulfonyl benzene and cis-2 , 6-dimethyl-piperazine . MS m/z (relative intensity, 70 eV) 322 (M+, 15) , 253 (12) , 252 (bp) , 119 (27) , 70 (40) . Preparation 7: cis-1- [3- (3 , 5-dimethyl-piperazin-l-yl) - phenyll -ethanone The titled compound was prepared in a similar manner as described in Example 1 from 3 -bromo-acetophenone and cis-2 , 6-dimethyl-piperazine . MS m/z (relative intensity, 70 eV) 232 (M+, 8) , 163 (10) , 162 (bp) , 132 (9) , 70 (12) . The following tests were used for evaluation of the compounds according to the invention. In vivo test : Behavior For behavioral testing, the animals were placed in separate motility meter boxes 50X50X50 cm equipped with an array of 16x16 photocells (Digiscan activity monitor, RXYZM (16) TAO, Omnitech Electronics, USA) , connected to an Omnitech Digiscan analyzer and a Apple Macintosh computer equipped with a digital interface board (NB DIO-24, National Instruments, USA) . Behavioral data from each motility meter box, representing the position (center of gravity) of the animal at each time, were recorded at a sampling frequency of 25 Hz and collected using a custom written LABView™ application. The data from each recording session were analyzed with respect to distance traveled and small-scale movements, e.g. stops in the center of the behavior recording arena, during the recording session. To determine stops in the center, velocity at each time point is calculated as the distance traveled since the preceding sample divided by the time elapsed since the preceding sample. The number of stops is then calculated as the number of times that the velocity changes from a non-zero value to zero. The number of stops in the center of the behavioral recording arena is calculated as the number of stops occurring at a position at least ten centimeters from the edges of the recording arena. For behavioral testing of habituated rats, the animals were placed in the motility meter boxes 30 minutes before the administration of test compound. Each behavioral recording session lasted 60 or 30 minutes, starting immediately after the injection of test compound. Similar behavioral recording procedures was ap- plied for non-habituated rats, habituated rats and drug pre-treated rats. Rats pretreated with d-amphetamine are given the dose 1,5 g/kg s.c. 5 min before the behavioral session in the motility meter. In vivo test: Neurochemistry After the behavioral activity sessions the rats were decapitated and their brains rapidly taken out and put on an ice-cold petri-dish. The limbic forebrain, the striatum, the frontal cortex and the remaining hemispheral parts of each rat were dissected and frozen. Each brain part was subsequently analyzed with respect to its content of monoamines and their metabolites. The monoaminer- gic indices analyzed were dopamine (DA), 3 , 4-dihydroxy- phenylacetic acid (DOPAC) , homovanillic acid (HVA) , 3- methoxytyramine (3-MT), serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) , and noradrenaline (NA) . All mono- aminergic indices in the dissected tissue were analyzed by means of HPLC with electrochemical detection as described by Svensson K, et al . , 1986, Naunyn- Schmiedeberg ' s Arch Pharmacol 334: 234-245 and references cited therein.

Claims: CLAIMS 1. A 3-substituted 4- (phenyl-N-alkyl) -piperazine or 4- (phenyl-N-alkyl) -piperidine compound of Formula 1: wherein: X is selected from the group consisting of N, CH, and C, however X may only be C when the compound comprises a double bond at the dotted line; Ri is selected from the group consisting of OS0 2 CF 3 , OS0 2 CH 3 , S0R 5 , S0 2 R 5 , COR5, CN, N0 2 , C0NHR 5 , CF 3 , 3- thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl , Br, and I, wherein R 5 is as defined below; R 2 is selected from the group consisting of C 1 -C4 alkyls, allyls, CH 2 SCH 3 , CH 2 CH 2 0CH 3 , CH 2 CH 2 CH 2 F, CH 2 CF 3 , 3,3,3- trifluoropropyl , 4 , 4 , 4-trifluorobutyl , and - (CH 2 ) -R 6 , wherein R 6 is as defined below; R 3 and R 4 are independently selected from the group con- sisting of H and Cι~C alkyls, however both R 3 and R 4 cannot be H at the same time; R 5 is selected from the group consisting of Cχ-C 3 alkyls, CF 3 , and N(R 2 ) 2/ wherein R 2 is as defined above; and R 6 is selected from the group consisting of C 3 -C 6 cyclo- alkyls, 2-tetrahydrofurane, and 3-tetra-hydrofurane, or a pharmaceutically acceptable salt thereof. 2. A compound according to claim 1, wherein X is CH or C. 3. A compound according to claim 1 or claim 2, wherein R x is selected from the group consisting of 0S0 2 CF 3 , OS0 2 CH 3 , S0 2 Me, S0 2 CF 3 , COCH 3 , CN, CF 3 , CON(CH 3 ) 2 and S0 2 N(CH 3 ) 2 . 4. A compound according to any one of the claims 1 - 3, wherein R 3 and R 4 both are CH 3 . 5. A compound according to any one of the claims 1 - 4, wherein R is selected from the group consisting of S0 2 CF 3 , S0 2 CH 3/ COCH 3 , CF 3 , and CN, and X is CH. 6. A compound according to any one of the claims 1 - 5, wherein R 2 is selected from the group consisting of n-propyl and ethyl . 7. A pharmaceutical composition comprising a com- pound or pharmaceutically acceptable salt according to any one of the claims 1 - 6. 8. A pharmaceutical composition according to claim 7, for treatment of a disorder in the central nervous system. 9. A pharmaceutical composition according to claim 7 or claim 8, for treatment of a dopamine mediated disorder. 10. A pharmaceutical composition according to any one of the claims 7 - 9, for treatment of a condition se- lected from the group consisting of movement disorders, such as iatrogenic and non-iatrogenic Parkinsonism, dys- kinesias and dystonias, tics, tremor, Tourette ' s disease, stuttering and other speech disorders. 11. A pharmaceutical composition according to any one of the claims 7 - 9, for treatment of a condition selected from the group consisting of iatrogenic and non- iatrogenic psychoses and hallucinoses, including schizophrenia and schizophreniform disorders. 12. A pharmaceutical composition according to any one of the claims 7 - 9, for treatment of a condition selected from the group consisting of mood and anxiety disorders, including manodepressive illness, depression and obsessive-compulsive disease. 13. A pharmaceutical composition according to any one of the claims 7 - 9, for treatment of a condition selected from the group consisting of neurodevelopmental and age-related disorders, including attention-deficit disorders, autism disorders, bradykinesia and bradyphre- nia and cognitive dysfunctions. 14. A pharmaceutical composition according to any one of the claims 7 - 9, for treatment of a condition se- lected from the group consisting of sleep disorders, sexual disorders, eating disorders, obesitas, and headaches and other pains . 15. A pharmaceutical composition according to any one of the claims 7 - 9, for improvement of motor func- tions, cognitive functions and related emotional disturbances in neurodegenerative and developmental disorders, and after brain injury induced by traumatic, toxic, inflammatory, infectious, neoplastic, vascular, hypoxic or metabolic causestreatment of a condition selected from the group consisting of schizophrenia and schizophreni- form disorders. 16. A pharmaceutical composition according to any one of the claims 7 - 9, for treatment of a substance related disorder. 17. Use of compound according to any one of the claims 1 - 6 for the manufacture of a pharmaceutical composition for treatment of a disorder in the central nervous system. 18. Use according to claim 17, wherein said pharma- ceutical composition is for treatment of a dopamine mediated disorder. 19. Use according to claim 17 or claim 18, wherein said pharmaceutical composition is for treatment of a condition selected from the group consisting of movement disorders, such as iatrogenic and non-iatrogenic Parkinsonism, dyskinesias and dystonias, tics, tremor, Tou- rette ' s disease, stuttering and other speech disorders. 20. Use according to claim 17 or claim 18, wherein said pharmaceutical composition is for treatment of a condition selected from the group consisting of iatrogenic and non-iatrogenic psychoses and hallucinoses, including schizophrenia and schizophreniform disorders. 21. Use according to claim 17 or claim 18, wherein said pharmaceutical composition is for treatment of a condition selected from the group consisting of mood and anxiety disorders, including manodepressive illness, de- pression and obsessive-compulsive disease. 22. Use according to claim 17 or claim 18, wherein said pharmaceutical composition is for treatment of a condition selected from the group consisting of neurode- velopmental and age-related disorders, including atten- tion-deficit disorders, autism disorders, bradykinesia and bradyphrenia and cognitive dysfunctions. 23. Use according to claim 17 or claim 18, wherein said pharmaceutical composition is for treatment of a condition selected from the group consisting of sleep disorders, sexual disorders, eating disorders, obesitas, and headaches and other pains . 24. Use according to claim 17 or claim 18, wherein said pharmaceutical composition is for improvement of motor functions, cognitive functions and related emotional disturbances in neurodegenerative and developmental disorders, and after brain injury induced by traumatic, toxic, inflammatory, infectious, neoplastic, vascular, hypoxic or metabolic causestreatment of a condition selected from the group consisting of schizophrenia and schizophreniform disorders. 25. Use according to claim 17 or claim 18, wherein said pharmaceutical composition is for treatment of a substance related disorder. 26. A method for treatment of a disorder in the central nervous system of a patient, wherein a pharmaceutically active amount of a compound or a pharmaceutically acceptable salt according to any one of the claims 1 - 6 is administered to said patient. 27. A method according to claim 26, for treatment of a dopamine mediated disorder. 28. A method according to claim 26 or claim 27, for treatment of a condition selected from the group consist- - SH SH SH . SH SH CQ O 4-> Pi 0 4-1 0 4-1 CQ 0 4-1 0 rβ 0 υ XI MH CQ H MH CQ CQ MH CQ β β MH CQ MH xi TS Ti MH 1 -H υ -H H -H QJ -H -H . 0 -H SH β β QJ CQ MH 0 β 4-1 QJ .. CQ rd .. rd rd O rβ 0 N - o ε - CQ SH CQ .. CQ CQ • H - CQ 0 O 0 QJ β XI SH β a -H r- β . 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Inventors: ANDERSSON BENGT, SONESSON CLAS, TEDROFF JOAKIM, WATERS NICHOLAS, WATERS SUSANNA, ANDERSSON, BENGT DI, SONESSON, CLAS, TEDROFF, JOAKIM, WATERS, NICHOLAS, WATERS, SUSANNA
Applicants: CARLBERG JENNY LF, CARLSSON A RESEARCH AB, LILJA ANDERS KRISTOFFER LM, SONESSON CLAS, SVAN INGELA MARIANNE LF, TEDROFF JOAKIM, WATERS NICHOLAS, WATERS SUSANNA, A. CARLSSON RESEARCH AB, CARLBERG, JENNY LF, LILJA, ANDERS, KRISTOFFER LM, SONESSON, CLAS, SVAN, INGELA, MARIANNE LF, TEDROFF, JOAKIM, WATERS, NICHOLAS, WATERS, SUSANNA
Application year: 2000
Main classification: C07D211
IPC codes: A61K31, A61P3, A61P15, A61P25, A61P43, C07D211, C07D295, C07D405