COMPOSITION FOR PREVENTING IODINE DEFICIENCY

Abstract: Disclosure of the invention is, a nutritive additive comprising as active ingredient at least one iodide loose or fixed fatty acid according to formula (1): where v has a value 0-2, x has a value 0-14, y has a value 0-13, z has a value 1-5, z1 has a value 1-6. It is suitable, that means to prevent insufficiency of iodine comprises some of the iodided fatty acid from the group, where belong oleic acid, limoliec acid, palmiting acid, erucic acid, or comprises any mixture of mentioned acids, or comprises mixture of any other fatty acids, that meet formula (1) listed above.

Description: COMPOSITION FOR PREVENTING IODINE DEFICIENCY Technical Field The technical solution concerns to nutritive additive to prevent insufficiency of iodine. Background Art Correction of the insufficiency of iodine is usually realised by means of iodised salt in many developed countries. Imperfection of such solution is, that additive potassium iodide is not enough stable and its volume is changing by proportional redistribution and also by regulary vanishing. Proportional redistribution consists in dissolving of the crystals of the potassium iodide in molecular film of water, while this film of water is covering crystals of sodium chloride, that are far less soluble in water. This is the way how dissolved potassium iodide penetrates the soft paper bag, causing absolute decrease of the volume in the salt and also as a consequence of gravity, potassium iodide is falling down, increasing its volume in the lower part and decreasing its volume in the upper part of the salt. Also, as the effect of warmth, light and humidity, potassium iodine oxidises to the elementary iodine, that is vanishing by sublimation. If the salt is inadequate stored, loss of iodine can be up to 30-50% per year. Therefore is potassium iodine substituted by potassium iodane (KIO 3 ), which is more stable but also more expensive. Beside this, VOZ suggest to decrease usage of salt due to prevention of cardiovascular diseases. This background art also shows imperfection, when iodine compounds are used for curing the arteriosclerosis. Present preparation consists of mixture of potassium salts, iodobehen fatty acid and some others iodided fatty acids. It comprises of 24% of iodine and 4% of potassium. However, it is contraindicated in the presence of decompensation of the cardiovascular system, hepatic and renal dysfunctions, Bassedow s disease, idiosyncrasy of iodine. It also does not have corrective effect to the activity of the thyroid, immunomodulation effect and others. There are published some information in scientific literature (in publication N.N. Kevorkov, B.A. Bachmetov: Possible contribution of the thyroid hormones to changes of function of the immunity system at stress / Stress and immunity: Themes of the union conference - Leningrad 1989 - pages 72 - 73) about immunomodulation effect of the thyroid hormones and also their adaptogen features. However, they are not used as a means of regulation of function of the immunity system and adaptogens for people. Disclosure of the Invitation It has been recognised that effective precaution of the iodine insufficiency, correction of the thyroid function, stimulation of the growth of the children, increase of the immunoreactivity of the organism, cut-down of the xenobiotic influence and others unpropitious influences of the environment, antiarteriogen effect can be achieved by using nutritive additive consisting iodine in the form of iodided fatty acids saturated by iodine. Disclosure of the invitation is, that this using nutritive additive comprises as a active ingredient at least one iodided loose or fixed fatty acid according to following formula: CH 3 -(CH z )x-[CH=CH-(CHz)v]z-[CH-CH-(CHz)v]z 1 -(CH z )y-COOH (1) J J where: v - has a value 0-2 x - has a value 0-14 y - has a value 0-13 z - has a value 1-5 zi - has a value 1-6 It is suitable, that means to prevent insufficiency of iodine comprises some of the iodided fatty acid from the group, where belong oleic acid, linoleic acid, palmitic acid, erucic acid, or comprises any mixture of mentioned acids, or comprises mixture any other fatty acids, that meet the formula (1) listed above. It is also suitable, that as an active ingredient is used the mixture of iodided loose or fixed fatty acid according to above mentioned formula (1) and that fatty acid are iodined as a part of natural vegetable oil or animal fat. One of the active ingredient of the preparation can be created, according to this invention, by direct bonding of certain amount of iodine to loose or fixed fatty acid or mixture of such acids. During this reaction are iodine atoms bonded to atoms of carbon of acids on the place of double bond. That way are di-, tetra-, hexa-, okta-, deka- iodided fatty acids created, ant this fatty acids have characteristic colour derivated from the colour of used natural vegetable oil or animal fat. It is important, that fatty acids, creating the active ingredient, were fully or at least partially iodided. It is suitable, for practical production utilisation, that the active ingredient of the nutritive additive, according to this invention, is prepared by bonding of certain amount of iodine with fatty acids, that are in vegetable oils or animal fats. In this process can be used industrially produced vegetable oils or animal fats. Porcine fat, fish oil and other fats. When preparing the active ingredient., it is possible to use 1 to 100 mg of crystallic iodine for 100 ml of vegetable oil or animal fat. It is suitable, to use the nutritive additive, according to this invention, in the form of capsules of different size containing daily dose of iodine from 20 to 400 μg, if required. Examples of embodiment Example no. 1 Preparation made of 100 ml of sunflower oil, containing chosen fatty acids: - palmitic acid - 6 % - oleic acid - 25 % - linoleic acid - 55 % - linolenic acid - 2 % - erucic acid - 1 % and 400 mg of iodine. This preparation was taken by patients suffering from psoriasis in a daily dose of 1 ml during a period of two weeks. After two weeks was observed increase of the immunoreactivity of the organism, and this increase was also proved by immunologic investigations of the blood coagulation followed by improvement of the health state. Example 2 Preparation made of 100 ml of sunflower oil and 20 mg of iodine was taken by patients with hypothyroidism in a daily dose of 1 ml during a period of 3 months / the preparation was taken daily for 2 weeks followed by 2 preparation-free weeks/ The activity of the thyroid was evaluated after 3 months of treatment. Normalisation of laboratory parameters of the pituitary-thyroid system /T3, T4, TTGV was established, and also improvement of the health state was affirmed. Example 3 Preparation made of 100 ml of colza oil, containing chosen fatty acids: - palmitic acid - 5 % - oleic acid - 60 % - linoleic acid - 20 % - linolenic acid - 10 % - erucic acid - 1 % and 80 mg of iodine. This preparation was taken by patients with signs and symptoms of large haemorrhages after a stroke in a daily dose of 0,5 ml during a period of 1 month. After two weeks of treatment was observed almost complete disappearance of the capillary bleeding. Example 4 Preparation made of 100 ml of porcine fat, containing chosen fatty acids: - palmitic acid - 5 % - stearic acid - 60 % - oleic acid - 20 % and 80 mg of iodine in a daily dose of 0,5 g during a period of 2 weeks was given to patients suffering from diabetes mellitus with trophic ulcers of the lower extremities. After this period of therapy was observed reduction of inflammation and improvement of above mentioned trophic processes. Industrial applicability Nutritive additive, according to this invention, is an effective means against iodine deficit, it adjusts the function of the thyroid gland, stimulates growth of children, increases immunoreactivity of the organism, cut-down of the xenobiotic influence and other unpropitious influences of the environment, and it has an antiarteriogen effect.

Claims: CLAIMS 1. Means to prevent insufficiency of iodine characterized by, that comprises vegetable oils or animal fats and iodine in ratio 1250: 1, while comprises vegetable oils and animal fats comprises comprises as one of the active ingredient at least one iodided loose or fixed fatty acid according to following formula: CH 3 -(CH z )x-[CH=CH-(CHz)v]z-[CH-CH-(CHz)v]z 1 -(CH z )y-COOH ( 1 ) J J where: v - has a random value 0-2 x - has a value 0-14 y - has a value 0-13 z - has a value 1-5 z \ - has a value 1-6 2. Means to prevent insufficiency of iodine according to claim 1 characterized by, that fatty acids are taken from the group, where belong oleic acid, linoleic acid, palmitic acid, erucic acid, and any mixture of mentioned acids with other fatty acids in a loose or fixed form.

Inventors: HANZEL JAROSLAV, HANZEL, JAROSLAV
Applicants: HANZEL JAROSLAV, HANZEL, JAROSLAV
Application year: 2000
Main classification: A23L1
IPC codes: A23L1, A61K31, A61K33, A61K36, A61P39