BENZENAMINE DERIVATIVES AS ANTI-COAGULANTS

Abstract: This invention is directed to benzenamine derivatives of formula (I): wherein A, W, m, n, R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are defined herein. These compounds are useful as anti-coagulants.

Description: BENZENAMINE DERIVATIVES AS ANTI-COAGULANTS This application claims the benefit of U S Provisional Application No 60/146,572, filed July 30, 1999, which is incorporated herein in full by reference Field of the Invention The present invention is directed to benzenamine derivatives and their pharmaceutically acceptable salts, which inhibit the enzyme, factor Xa, thereby being useful as anti-coagulants It also relates to pharmaceutical compositions containing the derivatives or their pharmaceutically acceptable salts, and methods of their use BACKGROUND OF THE INVENTION Factor Xa is a member of the trypsin-li e serine protease class of enzymes A one-to-one binding of factors Xa and Va with calcium ions and phospho pid forms the prothrombinase complex which converts prothrombin to thrombin Thrombin, in turn, converts fibnnogen to fibrin which polymerizes to form insoluble fibrin In the coagulation cascade, the prothrombinase complex is the convergent point of the intrinsic (surface activated) and extrinsic (vessel injury-tissue factor) pathways (Biochemistry (1991 ), Vol 30, p 10363, and Ce// (1988), Vol 53, pp 505-518) The model of the coagulation cascade has been refined further with the discovery of the mode of action of tissue factor pathway inhibitor (TFPI) (Seminars in Hematology (1992), Vol 29, pp 159-161 ) TFPI is a circulating multi-domain serine protease inhibitor with three Kunitz-type domains which competes with factor Va for free factor Xa Once formed, the binary complex of factor Xa and TFPI becomes a potent inhibitor of the factor Vila and tissue factor complex Factor Xa can be activated by two distinct complexes, by tissue factor-Vila complex on the "Xa burst" pathway and by the factor IXa-Vllla complex (TENase) of the "sustained Xa" pathway in the coagulation cascade After vessel injury, the "Xa burst" pathway is activated via tissue factor (TF) Up regulation of the coagulation cascade occurs via increased factor Xa production via the "sustained Xa" pathway Down regulation of the coagulation cascade occurs with the formation of the factor Xa-TFPI complex, which not only removes factor Xa but also inhibits further factor formation via the "Xa burst" pathway Therefore, the coagulation cascade is naturally regulated by factor Xa The primary advantage of inhibiting factor Xa over thrombin in order to prevent coagulation is the focal role of factor Xa versus the multiple functions of thrombin Thrombin not only catalyzes the conversion of fibπnogen to fibrin, factor VIII to VIIIA, factor V to Va, and factor XI to Xla, but also activates platelets, is a monocyte chemotactic factor, and mitogen for lymphocytes and smooth muscle cells Thrombin activates protein C, the in vivo anti-coagulant inactivator of factors Va and Villa, when bound to thrombomodulm In circulation, thrombin is rapidly inactivated by antithrombin III (ATIII) and heparm cofactor II (HCII) in a reaction which is catalyzed by heparm or other proteoglycan-associated glycosaminoglycans, whereas thrombin in tissues is inactivated by the protease, nexin Thrombin carries out its multiple cellular activation functions through a unique "tethered ligand" thrombin receptor (Cell (1991 ), Vol 64, p 1057), which requires the same anionic binding site and active site used in fibπnogen binding and cleavage and by thrombomodulm binding and protein C activation Thus, a diverse group of in vivo molecular targets compete to bind thrombin and the subsequent proteolytic events will have very different physiological consequences depending upon which cell type and which receptor, modulator, substrate or inhibitor binds thrombin Published data with the proteins antistasin and tick anti-coagulant peptide (TAP) demonstrate that factor Xa inhibitors are efficacious anti-coagulants {Thrombosis and Haemostasis (1992), Vol 67, pp 371-376, and Science (1990), Vol 248, pp 593-596) The active site of factor Xa can be blocked by either a mechanism-based or a tight binding inhibitor (a tight binding inhibitor differs from a mechanism-based inhibitor by the lack of a covalent link between the enzyme and the inhibitor) Two types of mechanism-based inhibitors are known, reversible and irreversible, which are distinguished by ease of hydrolysis of the enzyme-inhibitor link (Thrombosis Res (1992), Vol 67, pp 221-231 , and Trends Pharmacol Sci (1987), Vol 8, pp 303-307) A series of guanidino compounds are examples of tight-binding inhibitors (Thrombosis Res (1980), Vol 19, pp 339-349) Arylsulfonyl-arginine-pipendine-carboxylic acid derivatives have also been shown to be tight-binding inhibitors of thrombin (Biochem (1984), Vol 23, pp 85-90), as well as a series of arylamidine-containing compounds, including 3-amιdιnophenylaryl derivatives (Thrombosis Res (1983), Vol 29, pp 635-642) and bιs(amιdιno)benzyl cycloketones (Thrombosis Res (1980), Vol 17, pp 545-548) However, these compounds demonstrate poor selectivity for factor Xa Related Disclosures European Published Patent Application 0 540 051 (Nagahara et al ) describes aromatic amidine derivatives These derivatives are stated to be capable of showing a strong anticoagulant effect through reversible inhibition of factor Xa The synthesis of α,α'-bιs(amιdιnobenzylιdene)cycloalkanones and α,α'-bιs(amιdιnobenzyl)cycloalkanones is described in Pharmazie (1977), Vol 32, No 3, pp 141-145 These compounds are disclosed as being serine protease inhibitors U S Patent No 5,451 ,700 (Morπssey et al ) describes amidino compounds These compounds are stated to be useful as selective LTB 4 receptor antagonists U S Patent No 5,612,363 (Mohan et al ) describes Λ/,Λ/-dι(aryl) cyclic urea derivatives These compounds are stated to be factor Xa inhibitors, thereby being useful as anticoagulants U S Patent No 5,633,381 (Dallas et al ) describes (Z,Z), (Z.E) and (E.Z) isomers of substituted b/s(phenylmethylene)cycloketones These compounds are disclosed as being factor Xa inhibitors, thereby being useful as anticoagulants PCT Published Patent Application WO/96/28427 (Buckman et al ) describes benzamidine derivatives These compounds are stated to be factor Xa inhibitors, thereby being useful as anticoagulants PCT Published Patent Application WO/97/21437 (Arnaiz et al ) describes naphthyl- substituted benzimidazole derivatives These compounds are disclosed as being factor Xa inhibitors, thereby being useful as anticoagulants PCT Published Patent Application WO/97/29067 (Kochanny et al ) describes benzamidine derivatives that are substituted by ammo acid and hydroxy acid derivatives These compounds are stated to be factor Xa inhibitors, thereby being useful as anticoagulants U S Patent No 5,869,501 (Hirayama et al ) describes amidinonaphthyl derivatives and their use as factor Xa inhibitors The above references, published patent applications and U S patents are herein incorporated in full by reference SUMMARY OF THE INVENTION This invention is directed to compounds or their pharmaceutically acceptable salts which inhibit human factor Xa and are therefore useful as pharmacological agents for the treatment of disease-states characterized by thrombotic activity Accordingly, in one aspect, this invention provides compounds of formula (I) wherein each m is independently 0, 1 , 2, 3 or 4, R 1 is hydrogen, alkyl, alkylcarbonyl, phenylalylidenyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 8 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, alkoxycarbonyl, phenylcarbonyl (wherein the phenyl group is optionally substituted by carboxy or alkoxycarbonyl), carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), mono[dιalkoxycarbonyl]alkylamιnocarbonyl, mono[dιcarboxy]alkylamιnocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylaminosulfonyl, R 2 is -[C(R 7 ) 2 ] m -, -[C(R 7 ) 2 ] m -C(O)-N(R 8 )-, or -[C(R 7 ) 2 ] m -[C(R 8 )]=CH-, R 3 is -C(NH)NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 , R 4 is hydrogen, alkyl, alkylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminosulfonyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, or -C(NH)CH 3 each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, ammo, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl, R 6 is hydrogen, alkyl, hydroxy, alkoxy, aralkoxy (wherein the aryl group is optionally substituted by alkyl, halo or alkoxy), each R 7 and R 8 is independently hydrogen, alkyl, aryl, or aralkyl, and each R 9 is alkyl or aralkyl, as a single stereoisomer or a mixture thereof, or a pharmaceutically acceptable salt thereof In another aspect, this invention provides a method of treating a human having a disease-state characterized by thrombotic activity, which method comprises administering to a human in need thereof a therapeutically effective amount of a compound of formula (I) as described above In another aspect, this invention provides a method of treating a human having a disease-state alleviated by the inhibition of factor Xa, which method comprises administering to a human in need thereof a therapeutically effective amount of a compound of formula (I) as described above In another aspect, this invention provides a method of inhibiting human factor Xa in vitro by the administration of a compound of formula (I) DETAILED DESCRIPTION OF THE INVENTION Definitions As used in the specification and appended claims, unless specified to the contrary, the following terms have the meaning indicated "Alkyl" refers to a straight or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, containing no unsaturation, having from one to six carbon atoms, and which is attached to the rest of the molecule by a single bond e g , methyl ethyl, n-propyl, 1 -methylethyl (/so-propyl), n-butyl, n-pentyl, 1 ,1-dιmethylethyl (f-butyl), and "Alkylcarbonyl" refers to a radical of the formula -C(O)R a where R a is an alkyl radical as defined above, e g , acetyl, ethylcarbonyl, n-propylcarbonyl, and the like "Alkoxy" refers to a radical of the formula -OR a where R a is an alkyl radical as defined above, e g , methoxy, ethoxy, n-propoxy, 1 -methylethoxy (/so-propoxy), n-butoxy, n-pentoxy, 1 ,1-dιmethylethoxy (f-butoxy), and the like "Alkoxycarbonyl" refers to a radical of the formula -C(O)OR a where R a is an alkyl radical as defined above, e g , methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, 1-methylethoxycarbonyl (/so-propoxycarbonyl), n-butoxycarbonyl, n-pentoxycarbonyl, 1 ,1 -dimethylethoxycarbonyl ( -butoxycarbonyl), and the like "Alkoxycarbonylalkyl" refers to a radical of the formula -R a C(0)OR a where each R a is independently an alkyl radical as defined above, e g , methoxycarbonylmethyl, 2- (ethoxycarbonyl)ethyl, (n-propoxycarbonylmethyl, 1-methylethoxycarbonylmethyl (/so-propoxycarbonylmethyl), n-butoxycarbonylmethyl, n-pentoxycarbonylmethyl, 1 ,1-dιmethylethoxycarbonylmethyl (r-butoxycarbonyimethyl), and the like "Alkoxycarbonylalkylcarbonyl" refers to a radical of the formula -C(O)R a C(O)OR a where each R a is independently an alkyl radical as defined above, e g , methoxycarbonylmethylcarbonyl, 2-(ethoxycarbonyl)ethylcarbonyl, (n-propoxycarbonylmethylcarbonyl, 1-methylethoxycarbonylmethylcarbonyl (/so-propoxycarbonylmethylcarbonyl), n-butoxycarbonylmethylcarbonyl, n-pentoxycarbonylmethylcarbonyl, 1 ,1-dιmethylethoxycarbonylmethylcarbonyl (f-butoxycarbonylmethyl)carbonyl, and the like "Aryl" refers to a phenyl or naphthyl radical "Aralkyl" refers to a radical of the formula -R a R where R a is an alkyl radical as defined above, substituted by R b , an aryl radical, as defined above, e g , benzyl "Aralkoxy" refers to a radical of the formula -OR c where R c is an aralkyl radical as defined above, e g , benzyloxy, and the like "Amidino" refers to the radical -C(NH)NH 2 "Aminocarbonyl" refers to the radical -C(O)NH 2 "Ammosulfonyl" refers to the radical -S(O) 2 NH 2 "Aminocarbonylalkyl" refers to the radical -R a C(O)NH 2 , where R a is an alkyl radical as defined above, e g , aminocarbonylmethyl, 2-(amιnocarbonyl)ethyl, and the like "Aminocarbonylalkylcarbonyl" refers to the radical -C(O)R a C(O)NH 2 , where R a is an alkyl radical as defined above, e g , aminocarbonylmethylcarbonyl, 2- (amιnocarbonyl)ethylcarbonyl, and the like "Alkylsulfonyl" refers to a radical of the formula -S(O) 2 -R a where R a is an alkyl radical as defined above, e g , methylsulfonyl, ethylsulfonyl, r-butylsulfonyl, and the like "Arylsulfonyl" refers to a radical of the formula -S(O) 2 -R b where R b is an aryl radical as defined above, e g , phenylsulfonyl or naphthylsulfonyl "Carboxy" refers to the radical -C(O)OH "Carboxyalkyl" refers to a radical of the formula -R a C(O)OH, where R a is an alkyl radical as defined above, e g , carboxymethyl, 2-(carboxy)ethyl, 3-(carboxy)propyl, and the "Carboxyalkylcarbonyl" refers to a radical of the formula -C(O)R a C(O)OH, where R a is an alkyl radical as defined above, e g , carboxymethylcarbonyl, 2-(carboxy)ethylcarbonyl 3-(carboxy)propylcarbonyl, and the like "Dialkylamino" refers to a radical of the formula -N(R a )R a where each R a is independently an alkyl radical as defined above, e g , dimethylamino, methylethylammo, diethylamino, dipropylam o, ethylpropylamino, and the like "Dialkylaminocarbonyl" refers to a radical of the formula -C(O)N(R a )R a where each R a is independently an alkyl radical as defined above, e g , dimethylaminocarbonyl, methylethylammocarbonyl, diethylaminocarbonyl, dipropylaminocarbonyl, ethylpropylaminocarbonyl, and the like "Dialkylammosulfonyl" refers to a radical of the formula -S(O) 2 -N(R a )R a where each R a is independently an alkyl radical as defined above, e g , dimethylaminosulfonyl, methylethylammosulfonyl, diethylaminosulfonyl, dipropylaminosulfonyl, ethylpropylaminosulfonyl, and the like "Dialkylaminocarbonylalkyl" refers to a radical of the formula -R a C(O)N(R a )R a where each R a is independently an alkyl radical as defined above, e g , dimethylaminocarbonylmethyl, 2-(methylethylamιnocarbonyl)ethyl, diethylammocarbonylmethyl, 3-(dιpropylamιnocarbonyl)propyl, 4- (ethylpropylamιnocarbonyl)butyl, and the like "Halo" refers to bromo, chloro, lodo or fluoro "Haloalkyl" refers to an alkyl radical, as defined above, that is substituted by one or more halo radicals, as defined above, e g , tπfluoromethyl, difluoromethyl, tπchloromethyl, 2,2,2-tπfluoroethyl, 1 -fluoromethyl-2-fluoroethyl, 3-bromo-2-fluoropropyl, 1-bromomethyl-2-bromoethyl, and the like "Monoalkylamino" refers to a radical of the formula -NHR a where R a is an alkyl radical as defined above, e g , methylamino, ethylamino, propylamino, and the like "Monoalkylaminocarbonyl" refers to a radical of the formula -C(O)NHR a where R a is an alkyl radical as defined above, e g , methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, and the like "Mono[dιalkoxycarbonyl]alkylamιnocarbonyl" refers to a radical of the formula -C(O)N(H)[R a (C(O)OR a ) 2 ] where each R a is independently an alkyl radical as defined above, e g , [1 ,2-dιethoxycarbonyl)ethyl]amιnocarbonyl, and the like "Mono[dιcarboxy]alkylamιnocarbonyl" refers to a radical of the formula -C(O)N(H)[R a (C(O)OH) 2 ] where R a is an alkyl radical as defined above, e g , [1 ,2- dιcarboxy)ethyl]amιnocarbonyl, and the like "Monoalkylaminocarbonylalkyl" refers to a radical of the formula -R a C(O)NHR a where each R a is independently an alkyl radical as defined above, e g , methylaminocarbonylmethyl, 2-(ethylamιnocarbonyl)ethyl, 3-(propylamιnocarbonyl)propyl, and the like "Optional" or "optionally" means that the subsequently described event of circumstances may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not For example, "optionally substituted aryl" means that the aryl radical may or may not be substituted and that the description includes both substituted aryl radicals and aryl radicals having no substitution "Phenylalky denyl" refers to a radical of the formula -R e R d where R d is a phenyl radical and R e is a straight or branched chain unsaturated divalent radical consisting solely of carbon and hydrogen atoms, having from one to six carbon atoms, wherein the unsaturation is present only as double bonds and wherein a double bond can exist between the first carbon of the chain and the rest of the molecule, e g , ethyhdene, propylidene n-butyhdene, and the like "Phenylcarbonyl" refers to a radical of the formula -C(O)R d where R d is a phenyl radical "Pharmaceutically acceptable salt" includes both acid and base addition salts "Pharmaceutically acceptable acid addition salt" refers to those salts which retain the biological effectiveness and properties of the free bases, which are not biologically or otherwise undesirable, and which are formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as acetic acid, tπfluoroacetic acid, propionic acid, glyco c acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, sucαnic acid, fumaπc acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mande c acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like "Pharmaceutically acceptable base addition salt" refers to those salts which retain the biological effectiveness and properties of the free acids, which are not biologically or otherwise undesirable These salts are prepared from addition of an inorganic base or an organic base to the free acid Salts derived from inorganic bases include, but are not limited to, the sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like Preferred inorganic salts are the ammonium, sodium, potassium, calcium, and magnesium salts Salts derived from organic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, tπmethylamine, diethylamine, triethylamine, tnpropylamine, ethanolamme, 2-dιmethylamιnoethanol, 2-dιethylamιnoethanol, dicyclohexylamme, lysme, arginme, histidme, caffeine, procame, hydrabamine, cholme, betaine, ethylenediamine, glucosamine, methylglucamine, theobrom e, puπnes, piperazme piperidine, Λ/-ethylpιpeπdιne, polyamine resins and the like Particularly preferred organic bases are isopropylamine, diethylamine, ethanolamme, tπmethylamine, dicyclohexylamme, cholme and caffeine "Therapeutically effective amount" refers to that amount of a compound of the invention which, when administered to a human in need thereof, is sufficient to effect treatment, as defined below, for disease-states characterized by thrombotic activity The amount of a compound of the invention which constitutes a "therapeutically effective amount" will vary depending on the compound, the disease-state and its severity, and the age of the human to be treated, but can be determined routinely by one of ordinary skill in the art having regard to his own knowledge and to this disclosure "Treating" or "treatment" as used herein covers the treatment of a disease-state in a human, which disease-state is characterized by thrombotic activity, and includes (i) preventing the disease-state from occurring in a human, in particular, when such human is predisposed to the disease-state but has not yet been diagnosed as having (II) inhibiting the disease-state, / e , arresting its development, or (in) relieving the disease-state, / e , causing regression of the disease-state The yield of each of the reactions described herein is expressed as a percentage of the theoretical yield The compounds of the invention, or their pharmaceutically acceptable salts, may have asymmetric carbon atoms, oxidized sulfur atoms or quaternized nitrogen atoms in their structure The compounds of the invention and their pharmaceutically acceptable salts may therefore exist as single stereoisomers, racemates, and as mixtures of enantiomers and diastereomers The compounds may also exist as geometric isomers All such single stereoisomers, racemates and mixtures thereof, and geometric isomers are intended to be within the scope of this invention The nomenclature used herein is a modified form of the I U P A C system wherein the compounds of the invention are named as benzenamme derivatives For example, a compound of formula (I) wherein A is -O-, W is -N(R 4 )-, n is 1 , R 1 is 2- (carboxy )ethylcarbonyl, R 2 is -CH 2 -CH=CH-, R 3 is -C(NH)NH 2 , R 4 is methyl, R 5 is tπfluoromethyl, and R 6 is hydroxy, / e , a compound of the following formula is named herein as 4-(Λ/'-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2- (carboxy)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne Utility and Administration A. Utility The compounds of the invention are inhibitors of the serine protease, factor Xa, and are therefore useful in disease-states characterized by thrombotic activity based on factor Xa's role in the coagulation cascade (see Background of the Invention above) A primary indication for the compounds is prophylaxis for long term risk following myocardial infarction Additional indications are prophylaxis of deep vein thrombosis (DVT) following orthopedic surgery or prophylaxis of selected patients following a transient ischemic attack The compounds of the invention may also be useful for indications in which coumadin is currently used, such as for DVT or other types of surgical intervention such as coronary artery bypass graft and percutaneous transluminal coronary angioplasty The compounds are also useful for the treatment of thrombotic complications associated with acute promyelocytic leukemia, diabetes, multiple myelomas, disseminated mtravascular coagulation associated with septic shock, purpura fulminanas associated infection, adult respiratory distress syndrome, unstable angina, and thrombotic complications associated with aortic valve or vascular prosthesis The compounds are also useful for prophylaxis for thrombotic diseases, in particular in patients who have a high risk of developing such disease In addition, the compounds of the invention are useful as in vitro and in vivo diagnostic reagents for selectively inhibiting factor Xa without inhibiting other components of the coagulation cascade B. Testing The primary bioassays used to demonstrate the inhibitory effect of the compounds of the invention on factor Xa are simple chromogenic assays involving only serine protease, the compound of the invention to be tested, substrate and buffer (see, e g , Thrombosis Res (1979), Vol 16, pp 245-254) For example, four tissue human serine proteases can be used in the primary bioassay, free factor Xa, prothrombinase, thrombin (I la) and tissue plasminogen activator (tPA) The assay for tPA has been successfully used before to demonstrate undesired side effects in the inhibition of the fibnnolytic process (see, e g , J Med Chem (1993), Vol 36, pp 314-319) Another bioassay useful in demonstrating the utility of the compounds of the invention in inhibiting factor Xa demonstrates the potency of the compounds against free factor Xa in citrated plasma For example, the anticoagulant efficacy of the compounds of the invention will be tested using either the prothrombm time (PT), or activated partial thromboplastin time (aPTT) while selectivity of the compounds is checked with the thrombin clotting time (TCT) assay Correlation of the K, in the primary enzyme assay with the K, for free factor Xa in citrated plasma will screen against compounds which interact with or are inactivated by other plasma components Correlation of the K, with the extension of the PT is a necessary in vitro demonstration that potency in the free factor Xa inhibition assay translates into potency in a clinical coagulation assay In addition, extension of the PT in citrated plasma can be used to measure duration of action in subsequent pharmacodynamic studies For further information on assays to demonstrate the activity of the compounds of the invention, see R Lottenberg et al., Methods in Enzymology (1981 ), Vol 80, pp 341-361 , and H Ohno et al , Thrombosis Research (1980), Vol 19, pp 579-588 C. General Administration Administration of the compounds of the invention, or their pharmaceutically acceptable salts, in pure form or in an appropriate pharmaceutical composition, can be carried out via any of the accepted modes of administration or agents for serving similar utilities Thus, administration can be, for example, orally, nasally, parenterally, topically, transdermally, or rectally, in the form of solid, semi-solid, lyophihzed powder, or liquid dosage forms, such as for example, tablets, suppositories, pills, soft elastic and hard gelatin capsules, powders, solutions, suspensions, or aerosols, or the like, preferably in unit dosage forms suitable for simple administration of precise dosages The compositions will include a conventional pharmaceutical carrier or excipient and a compound of the invention as the/an active agent, and, in addition, may include other medicinal agents, pharmaceutical agents carriers, adjuvants, etc Generally, depending on the intended mode of administration, the pharmaceutically acceptable compositions will contain about 1% to about 99% by weight of a compound(s) of the invention, or a pharmaceutically acceptable salt thereof, and 99% to 1 % by weight of a suitable pharmaceutical excipient Preferably, the composition will be about 5% to 75% by weight of a compound(s) of the invention, or a pharmaceutically acceptable salt thereof with the rest being suitable pharmaceutical excipients The preferred route of administration is oral, using a convenient daily dosage regimen which can be adjusted according to the degree of severity of the disease-state to be treated For such oral administration, a pharmaceutically acceptable composition containing a compound(s) of the invention, or a pharmaceutically acceptable salt thereof, is formed by the incorporation of any of the normally employed excipients, such as, for example, pharmaceutical grades of mannitol, lactose, starch, pregelatmized starch, magnesium stearate, sodium saccharine, talcum, cellulose ether derivatives, glucose, gelatin, sucrose, citrate, propyl gallate, and the like Such compositions take the form of solutions, suspensions, tablets, pills, capsules, powders, sustained release formulations and Preferably such compositions will take the form of capsule, caplet or tablet and therefore will also contain a diluent such as lactose, sucrose, dicalcium phosphate, and the like; a disintegrant such as croscarmellose sodium or derivatives thereof, a lubricant such as magnesium stearate and the like; and a binder such as a starch, gum acacia, polyvinylpyrrolidone, gelatin, cellulose ether derivatives, and the like The compounds of the invention, or their pharmaceutically acceptable salts, may also be formulated into a suppository using, for example, about 0 5% to about 50% active ingredient disposed in a carrier that slowly dissolves within the body, e g , polyoxyethylene glycols and polyethylene glycols (PEG), e g , PEG 1000 (96%) and PEG 4000 (4%) Liquid pharmaceutically admmistrable compositions can, for example, be prepared by dissolving, dispersing, etc , a compound(s) of the invention (about 0 5% to about 20%), or a pharmaceutically acceptable salt thereof, and optional pharmaceutical adjuvants in a carrier, such as, for example, water, saline, aqueous dextrose, glycerol, ethanol and the like, to thereby form a solution or suspension If desired, a pharmaceutical composition of the invention may also contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents, antioxidants, and the like, such as, for example, citric acid, sorbitan monolaurate, tπethanolamine oleate, butylated hydroxytoluene, etc Actual methods of preparing such dosage forms are known, or will be apparent, to those skilled in this art, for example, see Remington's Pharmaceutical Sciences, 18th Ed , (Mack Publishing Company, Easton, Pennsylvania, 1990) The composition to be administered will, in any event, contain a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, for treatment of a disease-state alleviated by the inhibition of factor Xa in accordance with the teachings of this invention The compounds of the invention, or their pharmaceutically acceptable salts, are administered in a therapeutically effective amount which will vary depending upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of the compound, the age, body weight, general health, sex, and diet of the patient, the mode and time of administration, the rate of excretion, the drug combination, the severity of the particular disease-states, and the host undergoing therapy Generally, a therapeutically effective daily dose is from about 0 14 mg to about 14 3 mg/kg of body weight per day of a compound of the invention, or a pharmaceutically acceptable salt thereof, preferably, from about 0 7 mg to about 10 mg/kg of body weight per day, and most preferably, from about 1 4 mg to about 7 2 mg/kg of body weight per day For example, for administration to a 70 kg person, the dosage range would be from about 10 mg to about 1 0 gram per day of a compound of the invention, or a pharmaceutically acceptable salt thereof, preferably from about 50 mg to about 700 mg per day, and most preferably from about 100 mg to about 500 mg per day Preferred Embodiments Of the compounds of formula (I) as described in the Summary of the Invention, one preferred group of compounds are those compounds wherein A is -O-, W is -N(R 4 )-, each is independently 0, 1 or 2, n is 1 , R 2 is -[C(R 7 ) 2 ] m -C(O)-N(R 8 )-, and R 3 is - C(NH)NH 2 Of this group of compounds, more preferred compounds are selected from the group consisting of the following 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/-(3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, 4-(pιpeπdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenamine, 4-(Λ/"-(acetyl)pιpeπdιn-4-yl)oxy-/v- (Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenam e, -(Λ/"-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(amιnocarbonylmethyl)-Λ/-((Λ/-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, -(Λ/"-(1 -ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(1-(Λ/'-(3-amιdιnophenyl)amιnocarbonyl)- ethyl)benzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(ethoxycarbonylmethyl)-Λ/-((Λ/'-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(methyl)-Λ/-((Λ/-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, -(Λ/"-(1 -ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(ethoxycarbonylmethyl)-Λ/-(Λ/ '-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)-methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(methyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)-methylbenzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (Λ/'-(3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιpeπdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyi)methylbenzenamιne, -(Λ/"-(methyl)pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιpeπdιn-4-yl)oxy-Λ/-(1-methylethyl)-Λ/-(Λ/-(6-benzyloxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-Λ/-(1-methylethyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(1-methylethyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, and 4-(Λ/"-(methyl)pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne Another preferred group of compounds of the compounds of formula (I) as defined above in the Summary of the Invention is the group of compounds wherein A is -O-, W is -N(R 4 )-, each m is independently 0, 1 or 2, n is 1 , R 2 is -^(R 7 )^-, and R 3 is -C(NH)NH 2 Of this group of compounds, more preferred compounds are those compounds selected from the list consisting of the following 4-(pιpeπdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne, 4-(Λ/'-methylpιpeπdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)propyl)benzenamιne, 4-( Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)propyl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1 -yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1- yl)benzenamιne, 4-(Λ/'-(actyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(2- methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1 -yl)benzenamιne, and 4-(Λ/-(actyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl- 3-(6-hydroxy-3-amιdιnophenyl)prop-1-yl)benzenamιne Another preferred group of compounds of the compounds of formula (I) as defined above in the Summary of the Invention is the group of compounds wherein A is -O-, W is -N(R 4 )-, each m is independently 0, 1 or 2, n is 1 , R 2 is -[C(R 7 ) 2 ] m -[C(R 8 )]=CH-, R 3 is - C(NH)NH 2 , and R 8 is hydrogen Of this group of compounds, more preferred compounds are those compounds selected from the list consisting of the following 4-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/'-(1 -ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, 4-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-/V-(3-(3-amιdιnophenyl)prop-2-en-1 -yl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-nιtro-Λ/-(carboxymethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-ethoxycarbonyl-Λ/-(3-(3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-ethoxycarbonyl-Λ/-(3-(3-amιdιnophenyl)prop-2-en- 1 -yl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-fluoro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(2-(ethoxycarbonyl)propyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιpeπdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(pιpeπdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1 -yl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-ethoxycarbonyl-Λ/-(ethoxycarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-/V-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3,5-dιfluoro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/-acetylpιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(pιpeπdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3,5-dιfluoro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(1-methylethyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en- 1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-Λ -(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-fluoro-Λ/-(methoxycarbonylmethyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1 -yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(methoxycarbonylmethyl)-Λ/-(3- (3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(methyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(/ '-(1 -iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl- /-(aminocarbonylmethyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-fluoro-Λ/-(aminocarbonylmethyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-nitro-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1 -yl)benzenamine; -(piperidin-4-yl)oxy-3-carboxy-Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(piperidin-4-yl)oxy-3-methoxycarbonyl-/V-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-3-carboxy-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-methoxycarbonyl-Λ/-(3-(3-amidinophenyl)prop-2- en-1 -yl)benzenamine; -(Λ/-(methyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2- en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-acetyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methyl)piperidin-4-yl)oxy-3-thfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(/ '-(1-iminoethyl)pipehdin-4-yl)oxy-3-carboxy-A/-((1-methylethyl)carbonyl)-A/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1 -yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop- 2-en-1 -yl)benzenamιne, -( Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-((1-methylethyl)carbonyl)-/V-(3- (6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ,/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-acetyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(acetyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(methyl)pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2-(methoxycarbonyl)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, -(Λ/-(methyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-acetyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(methoxycarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-carboxy-Λ/-((1-methylethyl)carbonyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(amιnocarbonyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-(methoxycarbonyl)-Λ/-(2- (methoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(/V'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(aminocarbonyl)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methylsulfonyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methylsulfonyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1-methylethyl)carbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(methyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-A/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/-(ethoxycarbonyl)piperidin-4-yl)oxy-3-trifluoromethyl-A/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-(nitro)-Λ/-(aminocarbonylmethyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(ethoxycarbonylmethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1 ,2- di(ethoxycarbonyl)ethyl)aminocarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1 - yl)benzenamine; 4-(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1 ,2- di(carboxy)ethyl)aminocarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3-amidinophenyl)prop- 2-en-1 -yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1 ,2- di(ethoxycarbonyl)ethyl)aminocarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(carboxymethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1 ,2-di(carboxy)ethyl)aminocarbonyl)- Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(carboxy)phenyl)carbonyl)-A/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methyl)pipehdin-4-yl)oxy-3-trifluoromethyl-Λ-((1 ,2-di(carboxy)ethyl)aminocarbonyl)- Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(acetyl)piperidin-4-yl)oxy-3-thfluoromethyl-Λ/-((3,4-di(carboxy)phenyl)carbonyl)-Λ/-(3- (3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(/V-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-/V-((3,4- di(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(methyl)piperidin-4-yl)oxy-3-trifluoromethyl-/\/-((3,4-di(carboxy)phenyl)carbonyl)-Λ/- (3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; 4-(Λ/'-(carboxymethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(carboxymethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((3,4- dι(carboxy)phenyl)carbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(carboxymethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, and 4-(pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1-yl)- Λ/-(3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne Another preferred group of compounds of the compounds of formula (I) as defined above in the Summary of the Invention is the group of compounds wherein A is -O-, W is - N(R 4 )-, each m is independently 0, 1 or 2, n is 1 , R 2 is -[C(R 7 ) 2 ] m -[C(R 8 )]=CH-, R 3 is - C(NH)NH 2 , and R 8 is methyl Of this group of compounds, more preferred compounds are those compounds selected from the list consisting of the following 4-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(nιtro)-Λ/-(2-methyl-3-(3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, 4-(Λ/'-(acetyl)pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-benzyloxy-3-amιdιnophenyl)prop- 2-en-1 -yl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl-3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl- 3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl- 3-(3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, and 4-(Λ/'-(carboxymethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne Another preferred group of compounds of the compounds of formula (I) as defined above in the Summary of the Invention is the group of compounds wherein A is -O-, W is - N(R 4 )-, each m is independently 0, 1 or 2, n is 1 , R 2 is Of this group of compounds, more preferred compounds are those compounds selected from the list consisting of the following 4-(Λ/'-(1 -ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(acetyl)pιpeπdιn-4-yl)oxy-3-methoxy-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ-(3-(3- amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-/V-(ethoxycarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(ethoxycarbonylmethyl)-Λ/-(3- (3-amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-carboxy-/\/-(carboxymethyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(ethoxycarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)benzyl)- Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, and 4-(Λ/'-(1 -ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3-amιdιnophenyl)benzyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne Another preferred group of compounds of the compounds of formula (I) as defined above in the Summary of the Invention is the group of compounds wherein A is -O-, W is - O- or -S-, each m is independently 0, 1 or 2, n is 1 , R 2 is -[C(R 7 ) 2 ] m -[C(R 8 )]=CH-, and R 3 is - C(NH)NH 2 Of this group of compounds, more preferred compounds are those compounds selected from the list consisting of the following 4-(tetrahydropyran-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, and 4-(thιan-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-eπ-1 - yl)benzenamιne Of the preferred compounds named above, the most preferred compounds are selected from the group consisting of the following 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(carboxymethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((1 ,2- dι(carboxy)ethyl)amιnocarbonyl)-/V-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/'-(carboxymethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((3,4- dι(carboxy)phenyl)carbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/-(carboxymethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, -(Λ/'-(carboxymethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(carboxymethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((3,4- dι(carboxy)phenyl)carbonyl)-A/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, and 4-(Λ/"-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (A/'-(3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne Preparation of Compounds of The Invention As a matter of convenience, the following Reaction Schemes are directed to the preparation of compounds of formula (I) where W is -N(R 4 )- It is also understood that in the following Reaction Schemes combinations of substituents and/or variables (e g , R 5 or R 6 ) on the depicted formulae are permissible only if such combinations result in stable compounds In the following Reaction Scheme 1 depicting the preparation of compounds of formula (D), which are intermediates in the preparation of the compounds of the invention, A is -O- or -N(R 7 )-, m is 0 to 4 and each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, ammo, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl, Boc is t- butoxycarbonyl, and R 7 is hydrogen, alkyl, aryl, or aralkyl REACTION SCHEME 1 Compounds of formula (A) and formula (B) are commercially available or may be prepared according to methods known to those of ordinary skill in the art In general, compounds of formula (D) are prepared by first treating a compound of formula (A) in an aprotic solvent, for example, dimethylformamide, with a base, such as sodium hydride, at ambient temperature The reaction mixture is allowed to stir at ambient temperature for 1-4 hours, preferably for 2 hours To the reaction mixture is added a compound of formula B and the resulting reaction mixture is allowed to stir at ambient temperature for 8 to 12 hours The compound of formula (C) is isolated from the reaction mixture by standard isolation techniques, such as extraction, concentration and purification by flash chromatography The compound of formula (C) so formed is then reduced under standard hydrogenation conditions (Pd/C) to form a compound of formula (D) In the following Reaction Scheme 2 depicting the preparation of compounds of formula (H), which are intermediates in the preparation of the compounds of the invention, m is 0 to 4, and each R 6 is hydrogen, alkyl, hydroxy, alkoxy, aralkoxy (wherein the aryl group is optionally substituted by alkyl, halo or alkoxy) REACTION SCHEME 2 Compounds of formula (E) and formula (F) are commercially available or may be prepared according to methods known to those skilled in the art In general, compounds of formula (H) are prepared by first treating a compound of formula (E) in a polar solvent, such as dioxane, with an alkyl tin, such as hexamethylditin, in the presence of a catalyst, such as tnphenylphosphine palladium under standard coupling reactions conditions The compound of formula (F) is then added to the reaction mixture under similar conditions The compound of formula (G) is then isolated from the reaction mixture by standard isolation techniques, such as extraction, concentration and purification by flash chromatography The compound of formula (G) is then treated with a brominating agent, such as NBS, in the presence of a radical initiator, such benzoylperoxide, in an aprotic solvent, such as tetrachloromethane The resulting solution is heated at reflux for about 10 to 15 hours, preferably for about 15 hours The solvent is removed and the compound of formula (H) is isolated by flash chromatography In the following Reaction Scheme 3 depicting the preparation of compounds of formula (M), which are intermediates in the preparation of the compounds of the invention, A is -O- or -N(R 7 )-, m is 1 to 4, each R 5 is hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, am o, monoalkylammo, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl, and R 7 is hydrogen, /09093 28 alkyl, aryl, or aralkyl. REACTION SCHEME 3 Compounds of formula (J) and formula (K) are commercially available or may be prepared according to methods known to those skilled in the art. In general, the compounds of formula (M) are made in a similar manner to the compounds of formula (D) as described above in Reaction Scheme 1. In the following Reaction Scheme 4 depicting the preparation of compounds of formula (Q), which are intermediates in the preparation of the compounds of the invention, m is 1 to 4; each R 6 is hydrogen, alkyl, hydroxy, alkoxy, aralkoxy (wherein the aryl group is optionally substituted by alkyl, halo or alkoxy); and R 8 is independently hydrogen, alkyl, aryl, or aralkyl. (P) (Q) Compounds of formula (N) are commercially available or may be prepared according to methods known to those skilled in the art. In general, compounds of formula (Q) are prepared by first treating a compound of formula (N) in an organic solvent, such as methylene chloride, with the appropriate Wittig reagent, such as (tπphenylphosphoranylιdene)acetaldehyde The reaction mixture is stirred at reflux for 12 to 16 hours, preferably for about 16 hours The reaction mixture is then cooled, and the compound of formula (O) is isolated from the reaction mixture by standard isolation techniques, such concentration and purification by flash chromatography The compound of formula (O) in an organic solvent, such as methanol, is then treated optionally with a chelating agent, such as CeCI 3 , and the reaction mixture was stirred for 30 minutes to 1 hour, preferaby for about 1 hour, at 0°C A reducing agent such as sodium borohydnde, is then added, and the resulting mixture is stirred for an additional hour at 0°C The mixture is concentrated and resulting residue is dissolved in an aqueous basic solution, such as aqueous NaHCO 3 The compound of formula (P) is isolated from the solution by extraction, concentrated and purification by flash chromatography The compound of formula (P) is then treated with brominating agent, such as tπphenyphosphme bromine complex, at ambient temperature The resulting solution is stirred at 50°C to about 60°C, preferably at 60°C, for about 30 minutes to an hour, preferably for about 30 minutes. The reaction mixture is cooled to ambient temperature and concentrated. The compound of formula (Q) is isolated from the reaction mixture by t turation, filtration and concentration. In the following Reaction Scheme 5 depicting the preparation of compounds of formula (W), intermediates in the preparation of compounds of the invention, R 8 is independently hydrogen, alkyl, aryl, or aralkyl. REACTION SCHEME 5 Compounds of formula (R) are commercially available or may be prepared according to methods known to those skilled in the art. In general, compounds of formula (W) are prepared by first treating a compound of formula (R) in an aprotic solvent, such as methylene chloride, with a base, such as sodium hydride The reaction mixture is stirred for 30 minutes to an hour, preferably for about 30 minutes, at ambient temperature A protecting-group providing agent, such as 4-methoxybenzyl chloride is then added and the resulting reaction mixture is stirred for about 8 to 20 hours, preferably for about 16 hours, at ambient temperature The mixture is then diluted with water and the organic layer was isolated by extraction The compound of formula (S) was isolated form the organic layer by concentration and purification by flash chromatgraphy The compound of formula (S) so formed is then treated with a cyanide containing agent, such as Zn(CN) 2 , in the presense of a catalyst, such as Pd(PPH 3 ) 4 , in an organic solvent, such as dimethylformamide The resulting reaction mixture is stirred at around 90°C for 2 to 4 hours, preferably for about 3 hours, and then cooled to ambient temperature and diluted with an aqueous basic solution, such as 50% NH 4 OH The compound of formula (T) is isolated from the reaction mixture by standard isolation techniques, such as extraction, concentration and purification by flash chromatography The compound of formula (T) is then treated in a similar manner as described above for the compounds of formula (N) to form a compound of formula (U) The compound of formula (U) is then treated in a similar manner as described above for the compounds of formula (O) to form a compound of formula (V) The compound of formula (V) is then treated in a similar manner as described for compounds of formula (P) to form the compound of formula (W) In the following Reaction Scheme 6 depicting the preparation of compounds of formula (Y), which are intermediates of the compounds of the invention, each m is independently 0 to 4, A is -O- or -N(R 7 )-, each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy alkoxy, carboxy, alkoxycarbonyl, ammo, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl, each R 6 is hydrogen, alkyl, hydroxy, alkoxy, aralkoxy (wherein the aryl group is optionally substituted by alkyl, halo or alkoxy) Boc is f-butoxycarbonyl, R 7 is hydrogen, alkyl, aryl, or aralkyl, R 8 is hydrogen, alkyl, aryl, or aralkyl, and R 1 is alkyl, alkoxycarbonylalkyl, carboxyalkyl, ammocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, cyano). REACTION SCHEME 6 Compounds of formula (X) may be prepared according to methods disclosed herein are may be prepared according to methods known to those skilled in the art. In general, the preparation of compounds of formula (Y) from compounds of formula (X) is an alkylation procedure. For example, the compound of formula (Y) in an aprotic solvent, such as DMF, in the presence of a base, such as K 2 CO 3 , is treated with an appropriate alkylating agent, such as methyl bromoacetate. The mixture is stirred at 50°C to about 60°C, preferably at about 55°C, for 4 to 8 hours, preferably for about 6 hours. After the reaction mixture is cooled to ambient temperature, the compound of formula (Y) is isolated from the reaction mixture by standard isolation techniques, such as extraction, concentration and purification by flash chromatography In the following Reaction Scheme 6a depicting the preparation of compounds of formula (Yd), which are intermediates of compounds of the invention, A is -O- or N(R 7 )-, R 7 is hydrogen, alkyl, aryl or aralkyl; Boc is f-butoxycarbonyl; PG is a nitrogen protecting group, e.g, tπfluoromethylcarbonyl, and R 5 is nitro or carboxy REACTION SCHEME 6a (Yc) (Yd) Compounds of formula (Ya) and (B) are commercially available, or can be prepared according to methods known to those of ordinary skill in the art In general, compounds of formula (Yd) are prepared by first treating a compound of formula (Ya) with an appropriate protecting group providing agent, such as tπfluoroacetic anhydride, in an aprotic solvent, such as methylene chloride in the presence of a base, such as triethylamine, at temperatures between 0°C and ambient temperature, preferably at 0°C The reaction mixture is stirred at this temperature for 2 to 4 hours, preferably for about 3 hours The reaction mixture is then diluted and neutralized and the compound of formula (Yb) is then isolated from the reaction mixture by standard isolation techniques, such as extraction, concentration and purification by flash chromatography The compound of formula (Yb) is then treated with a compound of formula (B) under Mitsunobu reaction conditions, / e , to a mixture of the compound of formula (Yb) and the compound of formula (B) in a polar solvent, such as THF, in the presence of tnphenylphosphine, is added DEAD dropwise The reaction mixture is stirred at ambient temperature for 30 minutes to 1 hour, preferably for about 1 hour The compound of formula (Yc) is then isolated from the reaction mixture by standard isolation techniques, such as concentration and purification by flash chromatography Under basic hydrolysis conditions, such as treating the compound of formula (Yc) in a polar solvent, such as methanol and water, with a base, such as K 2 CO 3 , from ambient temperature to 100°C, preferably at 50°C, for 1 to 20 hours, preferably for 16 hours, the compound of formula (Yd) is formed In the following Reaction Scheme 6b depicting the preparation of compounds of formula (Yf), which are intermediates in the preparation of compounds of the invention, A is -O- or -N(R 7 )-, R 5 is alkoxycarbonyl, Boc is f-butoxycarbonyl, and R 7 is hydrogen, alkyl, aryl or aralkyl REACTION SCHEME 6b (Ye) (B) (Yf) Compounds of formula (Ye) and (B) are commercially available, or may be prepared according to methods known to those skilled in the art In general, compounds of formula (Yf) are prepared from compounds of formula (Ye) and compounds of formula (B) in a similar manner, / e , under Mitsunobu reaction conditions, as the compounds of formula (Yc) above In the following Reaction Scheme 7 depicting preparation of compounds of formula (le), which are compounds of the invention, A is -O- or -N(R 7 )-, m is 0 to 4 and each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, ammo, monoalkylamino, dialkylammo, aminocarbonyl monoalkylaminocarbonyl, or dialkylaminocarbonyl, R 1 is alkylcarbonyl, alkoxycarbonyl, phenylcarbonyl, carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, mono[dιalkoxycarbonyl]alkylamιno-carbonyl, mono[dιcarboxy]alkylamιnocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylammosulfonyl, Boc is f-butoxycarbonyl, OPMB is 4-methoxybenzyloxy, R 7 is hydrogen, alkyl, aryl, or aralkyl, and R 8 is hydrogen alkyl aryl, or aralkyl REACTION SCHEME 7 Compounds of formula (D) and (U) may be prepared by methods disclosed herein or by methods known to those skilled in the art In general, compounds of formula (le) are prepared by first reacting a compound of formula (D) under reductive amination conditions to form a compound of formula (Z) For example, to a mixture of a compound of formula (D) and formula (Z) in a polar solvent, for example, methanol, is added a mild acid, such as acetic acid The reaction mixture is stirred at ambient temperature for 15 minutes to 1 hour, preferably for 1 hour and then a reducing agent, such as NaCNBH 3 , is added and the reaction mixture is stirred at ambient temperature for 30 minutes to 1 hour, preferably for 1 hour The reaction mixture is concentrated and the residue is taken up in a mild base, such as NaHC0 3 The compound of formula (Z) is isolated from the reaction mixture by standard isolation techniques, such as extraction, concentration and purification by flash chromatography The compound of formula (Z) in an aprotic solvent, such as methylene chloride, is treated with an acylatmg agent, such as 4-chloro-4-oxobutyrate, in the presence of a base, such as pyndine, at 0°C The resulting solution is warmed to ambient temperature for 30 minutes to 1 hour, preferably for about 30 minutes The compound of formula (AA) is then isolated from the reaction mixture The compound of formula (AA) is dissolved in an anhydrous alkanol, preferably ethanol, and then anhydrous mineral acid, preferably HCI, is added to the solution over a period of time sufficient to saturate the acid into the solution while maintaining the reaction temperatures at about -78°C After saturation is complete, the reaction vessel is sealed and the reaction mixture is allowed to warm to ambient temperature and stirred between 12 and 24 hours, preferably for about 16 hours The solvent is removed in vacuo and the resulting residue is dissolved in fresh anhydrous alkanol, preferably ethanol, and then treated with anhydrous ammonia (gas) at temperatures from between ambient temperature and about 100°C from about 1 to about 48 hours, preferably at about 60°C and for about 2 hours The compound of formula (le) is then isolated from the reaction mixture by standard isolation techniques, for example, in vacuo removal of solvent and purification by high performance liquid chromatography (HPLC) During this last step, compounds of formula (AA) any protected oxygen or nitrogen substituent is de-protected Alternatively, compounds of formula (D) can be reacted with compounds of formula (Q) under standard alkylating conditions to form corresponding analogs of compounds of formula (Z), which can then be reacted in a similar manner as described above for compounds of formula (Z) and formula (AA) to form compounds of the invention Alternatively, compounds of formula (D) can be reacted with compounds of formula (H) under standard alkylating conditions to form corresponding analogs of compounds of formula (Z), which can then be reacted in a similar manner as described above for compounds of formula (Z) and formula (AA) to form compounds of the invention Alternatively, compounds of formula (I) wherein R 2 is -[C(R 7 ) 2 ] m -[C(R 8 )]=CH- (as illustrated above by the compounds of formula (le)), can be treated under hydrogenation conditions (e g , Pd/C) to make compounds of formula (I) wherein R 2 is -[C(R 7 ) 2 ] m - (saturated) In the following Reaction Scheme 8 depicting the preparation of compounds of formula (If), which are compounds of the invention, A is -O- or -N(R 7 )-; m is 0 to 4 and each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; R 7 is hydrogen, alkyl, aryl, or aralkyl; and R 8 is hydrogen, alkyl, aryl, or aralkyl. REACTION SCHEME 8 Compounds of formula (le) are prepared according to methods disclosed. In general, compounds of formula (If) are prepared by treating compounds of formula (le) under basic hydrolysis conditions, such as adding LiOH to a solution of a compound of formula (le) in a polar solvent, such as ethanol/water, and then stirring the reaction mixture at ambient temperature to about 100°C, preferably at ambient temperature, for 2 to 4 hours, preferably for about 4 hours. The compound of formula (If) is isolated from the reaction mixture by standard isolation techniques, such as neutralization of the mixture by the addition of an acid, concentration and separation by HPLC In the following Reaction Scheme 9 depicting the preparation of compounds of formula (Ig), which are compounds of the invention, A is -O- or -N(R 7 )-, R 1 is alkyl, alkylcarbonyl, phenylalylidenyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylammocarbonylalkyl, alkoxycarbonyl, phenylcarbonyl (wherein the phenyl group is optionally substituted by carboxy or alkoxycarbonyl), carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), mono[dιalkoxycarbonyl]alkylamιnocarbonyl, mono[dιcarboxy]alkylamιnocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylammosulfonyl, m is 0 to 4 and each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, ammo, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl, each R 7 is hydrogen, alkyl, aryl, or aralkyl, R 8 is hydrogen, alkyl, aryl or aralkyl, and each R 9 is alkyl or aralkyl REACTION SCHEME 9 Compounds of formula (If) are prepared according to methods disclosed herein In general, compounds of formula (Ig) are prepared from compounds of formula (If) by first treating a compound of formula (If) with ethyl acetimidate in a polar solvent, such as ethanol, in the presence of a base, such as triethylamine The reaction mixture is stirred at ambient temperature for 2 to 4 hours, preferably for about 4 hours The mixture is then acidified and concentrated, and the compound of formula (Ig) is isolated from the concentrate by HPLC In the following Reaction Scheme 10 depicting the preparation of compounds of formula (lb), which are compounds of the invention, A is -O- or -N(R 7 )-, R 1 is alkyl, alkylcarbonyl, phenylalylidenyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, alkoxycarbonyl, phenylcarbonyl (wherein the phenyl group is optionally substituted by carboxy or alkoxycarbonyl), carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), mono[dialkoxycarbonyl]alkylaminocarbonyl, mono[dιcarboxy]alkylaminocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylammosulfonyl; m is 0 to 4 and each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; each R 7 is hydrogen, alkyl, aryl, or aralkyl; each R 8 is hydrogen, alkyl, aryl, or aralkyl, and each R 9 is alkyl or aralkyl. REACTION SCHEME 10 Compounds of formula (la) are prepared by methods disclosed herein. In general, compounds of formula (lb) are prepared by first treating a compound of formula (la) in a polar solvent, such as methanol, with the optionally nitrogen substituted phenyl carbamate in the presence of a base, such as triethylamine The reaction mixture is stirred at ambient temperature for about 2 to 4 hours, preferably for about 3 hours, acidified with a mild acid and purified on HPLC to afford a compound of formula (lb) In the following Reaction Scheme 11 depicting the preparation of compounds of formula (Id), which are compounds of the invention, A is -O- or -N(R 7 )-; R 1 is alkyl, alkylcarbonyl, phenylalylidenyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, alkoxycarbonyl, phenylcarbonyl (wherein the phenyl group is optionally substituted by carboxy or alkoxycarbonyl), carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), mono[dialkoxycarbonyl]alkylaminocarbonyl, mono[dicarboxy]alkylaminocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylaminosulfonyl; m is 0 to 4 and each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; each R 7 is hydrogen, alkyl, aryl, or aralkyl; R 8 is hydrogen, alkyl, aryl or aralkyl; and each R 9 is alkyl or aralkyl: REACTION SCHEME 11 Compounds of formula (Ic) are prepared by methods disclosed herein. In general, compounds of formula (Id) are prepared by treating a compound of formula (Ic) in an aprotic solvent, such as acetonitrile, with an acylating agent, such as acetyl chloride, at ambient temperature. The resulting mixture is stirred at ambient temperature for about 1 hour to about 4 hours, preferably for 2 hours. A base, such as LiOH in water, is added to the reaction mixture and the mixture is stirred at ambient temperature for 1 to 3 hours, preferably for 2 hours. The reaction mixture is neutralized by addition of an acid, concentrated and purified by HPLC to afford the compound of formula (Id). In Reaction Scheme 12, which depicts the preparation compounds of formula (EE), which are intermediates in the preparation of the compounds of the invention, each R 7 is independently hydrogen, alkyl, aryl or aralkyl: REACTION SCHEME 12 Compounds of formula (BB) are commercially available or may be prepared according to methods known to those skilled in the art In general, compounds of formula (EE) are prepared by first treating a compound of formula (BB) in an aprotic solvent, such as a mixture of dimethylformamide and acetonitrile, with a protecting group providing agent, such as benzyl bromide, in the presence of a base, such as potassium carbonate The reaction mixture is heated at temperatures between ambient temperatures and 100°C, preferably at about 60°C, for about 3 to 6 hours, preferably for about 4 hours The compound of formula (CC) is isolated from the reaction mixture by standard isolation techniques, such as extraction, concentration and recrystalhzation The compound of formula (CC) is then treated with a reducing agent, such as tin chloride, under standard reducing conditions to form a compound of formula (DD) The compound of formula (DD) is then treated with an acylating agent, such as choroacetylchlonde, in the presence of an anhydrous base in a polar solvent, such as acetone under a nitrogen atmosphere, to afford a compound of formula (EE) In the following Reaction Scheme 13, depicting the preparation of compounds of formula (HH), which are intermediates in the preparation of compounds of the invention, A is -O- or -N(R 7 )-; m is 0 to 4 and each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; and Boc is f- butoxycarbonyl. REACTION SCHEME 13 (B) Compounds of formula (B) and formula (FF) are commercially available or may be prepared according to methods known to those skilled in the art. In general, the compounds of formula (HH) are prepared in a similar manner as the compounds of formula (D) described above. In the following Reaction Scheme 14 depicting the preparation of compounds of formula (Ih), which are compounds of the invention, A is -O- or -N(R 7 )-; m is 0 to 4; each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; Boc is f-butoxycarbonyl; and each R 7 is independently hydrogen, alkyl, aryl or aralkyl: REACTION SCHEME 14 Compounds of formula (EE) and formula (HH) may be prepared according to methods disclosed herein or may be prepared according to methods known to those skilled in the art. In general, compounds of formula (Ih) are prepared by first treating a compound of formula (HH) in an aprotic solvent, such as dimethyl formamide, and in the presence of a base, such as potassium carbonate, and sodium iodide with a compound of formula (EE). The reaction mixture is heated to about 80°C for 4 to 6 hours, preferably for about 5.5 hours. The mixture is allowed to cool and then poured onto ice water. The compound of formula (II) was isolated from the resulting slurry by standard isolation techniques, such as extraction, concentration and purification by flash chromatography. The compound of formula (II) so formed is then treated under similar conditions as the compound of formula (AA) to form the corresponding compound of formula (Ih). In the following Reaction Scheme 15 depicting the preparation of compounds of formula (Ii), which are compounds of the invention, X is O or NH; A is -O- or -N(R 7 )-; m is 0 to 4; each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; and each R 7 is hydrogen, alkyl, aryl or aralkyl: REACTION SCHEME 15 Compounds of formula (Ih) are prepared by methods disclosed herein. In general, the compounds of formula (Ii) are prepared by similar methods as those described above for compounds of formula (Ig). In the following Reaction Scheme 16, depicting the preparation of compounds of formula (Ij), which are compounds of the invention, X is O or NH; A is -O- or -N(R 7 )-; m is 0 to 4; each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; and each R 7 is hydrogen, alkyl, aryl or aralkyl: REACTION SCHEME 16 Compounds of formula (Ii) are prepared by methods disclosed herein In general, compounds of formula (Ij) are prepared by standard hydrogenating conditions Alternatively, instead of treating the above compounds of formula (AA) or formula (II) with anhydrous ammonia (gas), the compounds may be treated with a compound of the formula NH 2 OR 9 to afford the corresponding compound of formula (I) wherein R 3 is -C(NH)N(H)OR 9 Compounds of the invention containing an alkoxycarbonyl group may be prepared from the corresponding activated acid, such as an acid halide by techniques known to those of ordinary skill in the art Compounds of formula the invention containing an aminocarbonyl group, a monoalkylaminocarbonyl group, or a dialkylaminocarbonyl group may also be hydrolyzed under acidic conditions to prepare corresponding compounds of the invention containing a - C(O)OH group Compounds of the invention containing a carboxy group or an alkoxycarbonyl group may also be amidated under standard amidation conditions to form the corresponding compounds of the invention containing an aminocarbonyl group, a monoalkylaminocarbonyl group, or a dialkylaminocarbonyl group Compounds of the invention containing a nitro group may also be reduced under standard conditions to produce the corresponding compounds of the invention containing an ammo group, which may also be treated with the appropriate alkylating agents or acylatmg agents to afford the corresponding compounds of the invention containing a monoalkylamino group or a dialkylamino group Compounds of the invention may also be further treated with the appropriate acid halide, preferably acid chloride, or with the appropriate acid anhydride or an equivalent, to yield compounds of the invention wherein R 3 is -C(NH)N(H)C(O)R 7 where R 7 is hydrogen, alkyl, aryl or aralkyl Alternatively, compounds of the invention may further be treated with a compound of formula CI-C(O)-OR 9 or its functional equivalent to yield compounds of the invention where R 3 is -C(NH)N(H)C(O)OR 9 Alternatively, compounds of the invention may also be further treated with compounds of the formula R 9 -S(O) 2 -ιmιdazole (where R 9 is defined above in the Summary of the Invention) in a polar solvent, such as methylene chloride, at ambient temperature to afford compounds of the invention where R 9 is -C(NH)N(H)S(O) 2 R 9 where R 9 is defined above in the Summary of the Invention Alternatively, compounds of formula the invention may be further treated with an appropriately Λ/-R 7 -substιtuted phenylcarbamate in a polar solvent, preferably methylene chloride, at ambient temperature, for about 6 to 24 hours, preferably for about 12 hours, to afford compounds of the invention where R 3 is -C(NH)N(H)C(O)N(H)R 7 where R 7 is defined above in the Summary of the Invention All compounds of the invention as prepared above which exist in free base or acid form may be converted to their pharmaceutically acceptable salts by treatment with the appropriate inorganic or organic base or acid Salts of the compounds prepared above may be converted to their free base or acid form by standard techniques * * * * * The following specific preparations and examples are provided as a guide to assist in the practice of the invention, and are not intended as a limitation on the scope of the invention PREPARATION 1 (Compounds of formula (D)) A. To 4-hydroxy-Λ/-(f-butoxycarbonyl)piperidine (10.0 g) in DMF was added NaH (2.2 g) at ambient temperature. The reaction mixture was stirred at ambient temperature for 2 hours. 4-Flouro-3-trifluoromethyl-1 -nitrobenzene (5.3 mL) was added and the reaction mixture was stirred overnight at ambient temperature. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with aqueous NaHCO 3 and aqueous HCI, dried over sodium sulfate, concentrated and purified on silica gel column (hexane/ethyl acetate, gradient) to afford a compound of formula (C), 4-(Λ/-(f-butoxycarbonyl)piperidin-4-yl)oxy-3-trifluoromethyl-1 -nitrobenzene in 80% yield. B. In a similar manner, other compounds of formula (C) are prepared. C. 4-(Λ/-(f-butoxycarbonyl)piperidin-4-yl)oxy-3-trifluoromethyl-1 -nitrobenzene was dissolved in methanol in the presence of Pd/C. The solution was hydrogenated at 50 psi for 1 hour until hydrogen intake was completed. The catalyst was filtered off and the filtrate was concentrated to afford 4-[(Λ/-(f-butoxycarbonyl)piperidin-4-yl)oxy]-3- t fluoromethylbenzenamine, >95%. D. In a similar manner, other compounds of formula (D) are prepared. PREPARATION 2 (Compounds of formula (H)) A. A mixture of 3-bromobenzonitrile (910 mg), Pd(Ph 3 P) 4 (290 mg), (Me 3 Sn) 2 (1.64 g) and dioxane (20 mL) was sealed under argon in a pressure tube. The tube was then heated at 100-110°C for 3 hours with stirring and another 15 hours at 80°C. To the reaction mixture was added 1-bromo-3-methylbenzene (940 mg), Pd(PPh 3 ) 4 (290 mg) and dioxane (5 mL) under argon. The sealed tube was heated at 135-140°C with stirring for two days. The catalyst was filtered off and the filtrate was poured into water and extracted with ethyl acetate (3X). The organic layer was washed with brine, dried over Mg 2 SO 4 , concentrated and purified on silica gel column (ethyl acetate/hexane, 1 :3) to afford 0.64 g of 3-(3-cyanopheny!)-1-methylbenzene. B. In a similar manner, other compounds of formula (G) are prepared. C. A mixture of 3-(3-cyanobenzene)-1-methylbenzene (0.73 g), NBS (0.712 g), and benzoylperoxide (92 mg) in CCI 4 was heated at reflux for 15 hours After removal of the solvent the crude product was separated on silica gel column (ethylacetate/hexane=1 3) to afford 3-(3-cyanophenyl)-1-(bromomethyl)benzene (0 6 g) D In a similar manner, other compounds of formula (H) are prepared PREPARATION 3 (Compounds of formula (M)) A To 4-hydroxy-Λ/-methylpιperιdιne (13 0 g) in DMF was added NaH (4 2 g) at ambient temperature The reaction mixture was stirred at ambient temperature for 3 hours 4-fluoro-3-trιfluoromethyl-1 -nitrobenzene (22 g) was added at -10°C and the reaction was stirred overnight at ambient temperature The reaction was diluted with water and extracted with ethyl acetate The organic layer was washed with brine, dried over sodium sulfate, concentrated and purified on silica gel column (hexane/ethyl acetate B In a similar manner, other compounds of formula (L) are prepared C 4-(Λ/-methylpιperιdιn-4-yl)oxy-3-trιfluoromethyl-1 -nitrobenzene was dissolved in methanol in the presence of Pd/C The solution was hydrogenated at 50 psi for 1 hour until hydrogen intake was completed The catalyst was filtered off and the filtrate was concentrated to afford 4-(Λ/-methylpιperιdιn-4-yl)oxy-3- tπfluoromethylbenzenamine, >95% D In a similar manner, other compounds of formula (M) are prepared PREPARATION 4 (Compounds of formula (Q)) A A mixture of 3-cyanobenzaldehyde (2 0 g) and (tπphenylphosphoranylidene) acetaldehyde (5 0 g) in 100mL CH 2 CI 2 was stirred at reflux for 16 hours The reaction was cooled, concentrated and purified on silica gel column (ethyl acetate/hexane=3/7) to afford 2 2 g of 3-cyano-1-(2-formylethenyl)benzene as a yellow oil B In a similar manner, other compounds of formula (O) are prepared C To 3-cyano-1-(2-formylethenyl)benzene (1 g) in 30 mL of MeOH were added CeCI 3 (1 88 g) and the resulting solution was stirred for 30 minutes and cooled to 0°C To the solution was then added NaBH 4 (0 29 g) The resulting solution was stirred for 1 hour at 0°C and concentrated The residue was taken up in 100 mL of saturated aqueous NaHCO 3 and extracted with ethyl acetate (3X) The organic layer was dried, concentrated and purified on silica gel column (ethyl acetate/hexane, 1 4) to give 0 73 g of 3-cyano-1-(3-hydroxyprop-2-en-1yl)benzene D In a similar manner, other compounds of formula (P) are prepared E To a suspension of Ph 3 P (1 0 g) in 40 mL of MeCN at 0°C was added bromine (0 6 g) and the mixture was stirred at 0°C for 15 minutes and then warmed to ambient temperature To the suspension of Br 2 PPh 3 was then added 3-cyano-1-(3- hydroxyprop-2-en-1yl)benzene (0 5 g) in 10 mL MeCN dropwise The resulting solution was stirred at 60°C for 30 minutes, cooled to ambient temperature and concentrated The residue was triturated with 10% hexane in ethyl acetate The mixture was filtered through a silica gel pad and the filtrate was concentrated to afford 0 71 g of 3-cyano-1-(3- bromoprop-2-en-1yl)benzene as a yellow oil F In a similar manner, other compounds of formula (Q) are prepared PREPARATION 5 (Compounds of formula (W)) A To 3-bromo-6-hydroybenzaldehyde (5 g) in 100 mL CH 2 CI 2 was added NaH (1 0 g) and it was then stirred for 30 minutes at ambient temperature 4- methoxybenzyl chloride (4 29 g) was added to the above solution and stirring was continued for 16 hours at ambient temperature The reaction was diluted with 100 mL of water and the aqueous layer was extracted with ethyl acetate (3X) The organic layer was dried, concentrated and purified on silica gel column (ethyl acetate/hexane, 3 7) to afford 3-bromo-6-((4-methoxybenzyl)oxy)benzaldehyde (6 7 g) as a white solid B A mixture of 3-bromo-6-((4-methoxybenzyl)oxy)benzaldehyde (4 g), Zn(CN) 2 (1 g) and Pd(PPh 3 ) 4 (4 32 g) in 40 mL DMF was stirred at 90°C for 3 hours, cooled to ambient temperature and diluted with 100 mL 50% NH 4 OH The aqueous layer was extracted with ethyl acetate (3X) The organic layer was dried, concentrated and purified on silica gel column (ethyl acetate/hexane, 1 4) to afford 2 8 g of 3-cyano-6-((4- methoxybenzyl)oxy)benzaldehyde as a yellow solid C A mixture of 3-cyano-6-((4-methoxybenzyl)oxy)benzaldehyde (2 8 g) and (trιphenylphosphoranylιdene)acetaldehyde (3 5 g) in 40 mL CH 2 CI 2 was stirred at reflux for 16 hours The solution was cooled to ambient temperature, concentrated and purified on silica gel column (ethyl acetate/hexane/CH 2 CI 2 , 1 8 3) to give 3-cyano-6-((4- methoxybenzyl)oxy)-1-(2-formylethenyl)benzene (2 8 g) as a yellow solid D To 3-cyano-6-((4-methoxybenzyl)oxy)-1-(2-formylethenyl)benzene (2 30 g) in 100 mL solution of CH 2 CI 2 /MeOH/H 2 O (2 7 1 ) was added NaBH 4 (0 29 g) at 0°C The resulting solution was stirred at 0°C for 1 hour and concentrated The resulting residue was diluted with 100 mL of saturated aqueous NaHCO 3 and extracted with ethyl acetate (3X) The organic layer was dried, concentrated to afford 3-cyano-6-((4- methoxybenzyl)oxy)-1-(3-hydroxyprop-2-en-1-yl)benzene (92 3 g) as a yellow solid E To a suspension of Ph 3 P (2 4 g) in 30 mL of MeCN at 0°C was added bromine (1 5 g) and the mixture was stirred at 0°C for 15 minutes and then warmed to ambient temperature To the suspension of Br 2 PPh 3 was then added 3-cyano-6-((4- methoxybenzyl)oxy)-1-(3-hydroxyprop-2-en-1-yl)benzene (2 3 g) in 20 mL MeCN drop- wise The resulting solution was stirred at ambient temperature for 1 hour, cooled to ambient temperature and concentrated The residue was purified on silica gel column (ethyl acetate/hexane, 1 9) to afford 3-cyano-6-((4-methoxybenzyl)oxy)-1-(3-bromoprop- 2-en-1-yl)benzene (0 81 g) as a yellow oil PREPARATION 6 (Compounds of formula (Y)) A To 4-(Λ/-(f-butoxycarbonyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(3-(3- cyanophenyl)prop-2-en-1-yl)benzenamιne (0 39g) and K 2 CO 3 (0 56 g) in DMF was added methyl bromoacetate The mixture was stirred at 55°C for 6 hours The reaction was cooled, diluted with water and extracted with ethyl acetate (3X) The organic layer was concentrated and purified on silica gel column to afford 4-(Λ/'-(f-butoxycarbonyl)pιperιdιn- 4-yl)oxy-3-nιtro-Λ/-(methoxycarbonylmethyl)-Λ/-(3-(3-cyanophenyl)prop-2-en-1- yl)benzenamιne (0 15 g) B In a similar manner, other compounds of formula (Y) are prepared PREPARATION 6a (Compounds of formula (Yd)) A To 4-hydroxy-3-nιtrobenzenamιne (10 0 g) in methylene chloride (60 mL) was added triethylamine (27 mL) and tπfluoroacetic anhydride (10 9 mL) at 0°C The reaction was stirred at 0°C for three hours The reaction was diluted with water, acidified and extracted with ethyl acetate The organic layer was dried, concentrated and purified on silica gel column (ethyl acetate/hexane, 1 1) to afford 4-hydroxy-3-nιtro-Λ/- (trιfluoromethylcarbonyl)benzenamιne (10 0 g) B In a similar manner, other compounds of formula (Yb) are prepared C To 4-hydroxy-3-nιtro-Λ/-(trιfluoromethylcarbonyl)benzenamιne (10 0 g), tnphenylphosphme (22 1 g) and 4-hydroxy-Λ -(f-butoxycarbonyl)pιpeπdιne (17 0 g) in THF (30 mL) was added DεAD (13 5 mL) drop-wise The reaction was stirred at ambient temperature for 1 hour, concentrated and purified on silica gel column (ethyl acetate/hexane, gradient) to afford 4-(Λ/'-(f-butoxycarbonyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/- (tπfluoromethylcarbonyl)benzenamιne D In a similar manner, other compounds of formula (Yc) are prepared E To 4-(/V'-(f-butoxycarbonyl)pιpeπdιn-4-yl)oxy-3-nιtro-Λ/- (tπfluoromethylcarbonyl)benzenamιne in methanol (150 mL) and water (150 mL) was added K 2 CO 3 (6 0 g) and the reaction was heated to 50°C for overnight The reaction was extracted with ethyl acetate The extract was dried, concentrated and purified on silica gel column (ethyl acetate/hexane) to afford 4-(Λ/'-(f-butoxycarbonyl)pιpeπdιn-4- yl)oxy-3-nιtrobenzenamιne (11 0 g) F In a similar manner, other compounds of formula (Yd) are prepared PREPARATION 6b (Compounds of formula (Yf)) A To 4-hydroxy-2-(methoxycarbonyl)benzenamιne (6 8 g), tnphenylphosphme (14 2 g) and 4-hydroxy-Λ/-(f-butoxycarbonyl)pιpeπdιne (9 06 g) in THF (200 mL) was added DEAD (9 51 g) drop-wise at ambient temperature The reaction was stirred at ambient temperature for overnight, concentrated and re-dissolved in ether The ether layer was washed with 0 5 N NaOH aqueous solution, water and brine It was then concentrated and purified on silica gel column (ethyl acetate/hexane, gradient) to afford 4- (Λ/'-(f-butoxycarbonyl)pιperιdιn-4-yl)oxy-2-(methoxycarbonyl)benzenamιne (7 31 g) B In a similar manner, other compounds of formula (Yf) are prepared PREPARATION 7 (Compounds of formula (EE)) A A solution of 3-nιtro-4-hydroxybenzonιtrιle (10 g, 61 mmol) in a mixture of 40 mL of dimethylformamide and 100 mL of acetonitrile was stirred as anhydrous potassium carbonate (10 1 g, 73 2 mmol) and benzyl bromide (10 4 g, 61 mmol) were added The reaction was heated at 60°C for about 4 h The reaction was filtered and the solid was washed with ethyl acetate The filtrate was washed with water The organic layers were washed with water and brine, dried and concentrated The solid was recrystallized from acetone/hexane to give 14 g (90%) of 3-nιtro-4- (benzyloxy)benzonιtrιle, as a white solid B A solution of 3-nιtro-4-(benzyloxy)benzonιtrιle (14g, 55 mmol) in 300 mL of ethyl acetate was stirred as tin chloride (61 g, 270 mmol) was added The reaction was heated at reflux for a total of 5 hours The reaction was allowed to cool and poured into ice water containing 68 g of potassium bicarbonate The reaction was filtered through celite The aqueous layer was washed with ethyl acetate (2x) The combined organic layers were washed with water (2x) and brine, dried and concentrated to give 12 5 g of a product Purification of the product by flash chromatography on silica gel using a step gradient of 20, 40, and 50% ethyl acetate in hexane gave 7 3 g of 3-amιno-4- (benzyloxy)benzonιtrιle, NMR (CDCI 3 , TMS) δ 5 16 (s, 2), 6 84 (d, 1 ), 6 91 (s, 1 ), 7 04 (d, 1 ), 7 43 (m, 5) ppm C A slurry of 3-amιno-4-(benzyloxy)benzonιtrιle (7 g, 31 2 mmol) and anhydrous potassium carbonate (8 6 g, 62 4 mmol) in 50 mL of acetone was stirred under nitrogen as chloroacetylchlonde (2 6 mL, 33 mmol) was added portion-wise The reaction was stirred overnight The reaction was poured into ice water and the liquid was neutralized with 6 N hydrochloric acid The resulting solid was isolated by filtraton, washed with water, and dried under reduced pressure to give 3- ((chloromethyl)carbonylamιno)-4-(benzyloxy)benzonιtπle (8 3g) as a white solid, NMR (CDCI 3 , TMS) δ 4 22 (s, 2), 5 23 (s, 2), 7 03 (d, 1 ), 7 43 (m, 7), 8 73 (d, 1 ) PREPARATION 8 (Compounds of formula (HH)) A A slurry of hexane-washed sodium hydride (3 g, 75 mmol) in dimethyl formamide (80 mL) was stirred as a solution of Λ/-(f-butoxycarbonyl)-4-hydroxypιperιdιne (10 g, 50 mmol) in dimethyl formamide (10 mL) was added dropwise Slight heating was used to initiate reaction, but the reaction needed to be cooled in an ice bath to control the reaction rate Approximately 30 mm after the addition was complete, solid 4-fluoro-1 - nitrobenzene (7 4 g, 52 mmol) was added at once The reaction was stirred for about 3 hours The reaction was poured into ice water The pH of the resulting liquid was adjusted to neutrality with 1 N hydrochloric acid The resulting solid was isolated by filtration, washed with water, and dried under reduced pressure to give 16 g of 4-(Λ/-(f- butoxycarbonyl)pιperιdιn-4-yl)oxy-1 -nitrobenzene, NMR (CDCI 3 , TMS) δ 1 45 (s, 9), 1 72 (m, 2), 1 98 (m, 2), 3 38 (m, 2), 3 68 (m, 2), 4 62 (m, 1 ), 6 98 (m, 2), 8 19 (m, 2) B In a similar manner, other compounds of formula (GG) are prepared C A slurry of 4-(Λ/-(f-butoxycarbonyl)pιperιdιn-4-yl)oxy-1 -nitrobenzene (15 1 g, 46 8 mmol) in absolute ethanol (500 mL) and methanol (200 mL) was purged with nitrogen, treated with 10% palladium on carbon (1 2 g, 50% water by wt ) and placed on a Parr Hydrogenator under 43 psi of hydrogen gas The catalyst was removed by filtration Solvent removal under reduced pressure gave a solid after drying Purification by flash silica gel chromatography using a step gradient of 50 to 85% ethyl acetate in hexane gave 11 7 g of 4-(Λ/-(f-butoxycarbonyl)pιpeπdιn-4-yl)oxybenzenamιne, NMR (CDCI 3 , TMS) δ 1 45 (s, 9), 1 7 (m, 2), 1 86 (m, 2), 3 25 (m, 2), 3 68 (m, 2), 4 25 (m, 1 ), 6 63 (m, 2), 6 76 (m, 2) D In a similar manner, other compounds of formula (HH) are prepared EXAMPLE 1 (Compounds of formula (le)) A To a mixture of 4-[(Λ/-(f-butoxycarbonyl)pιpeπdιn-4-yl)oxy]-3- tπfluoromethyl-benzenamine (4 9 g) and 3-cyano-6-((4-methoxybenzyl)oxy)-1-(2- formylethenyl)benzene (4 g) in MeOH (80 mL) was added acetic acid (0 73 g) The resulting solution was stirred at ambient temperature for 15 minutes and then NaCNBH 3 was added The resulting solution was stirred at ambient temperature for 1 hour and concentrated The residue was taken up in 100 mL of aqueous NaHCO 3 and extracted with ethyl acetate (3X) The organic layer was dried, concentrated and purified on silica gel column (ethyl acetate/hexane, 3 7) to afford 5 7 g of 4-(Λ/-(f-butoxycarbonyl)pιperιdιn- 4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-((4-methoxybenzyl)oxy)-3-cyanophenyl)prop-2-en-1- yl)benzenamιne as a yellow oil B In a similar manner, other compounds of formula (Z) are prepared C To 4-(Λ/'-(f-butoxycarbonyl)pιpeπdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(6-((4- methoxybenzyl)oxy)-3-cyanophenyl)prop-2-en-1-yl)benzenamιne (1 39 g) in 20 mL of CH 2 CI 2 was added ethyl 4-chloro-4-oxobutyrate (0 43 g) and pyndine (1 mL) at 0°C The resulting solution was allowed to warm to ambient temperature for 30 minutes and then diluted with 100 mL CH 2 CI 2 The organic layer was washed with saturated copper sulfate, dried and concentrated to afford 4-(Λ/'-(f-butoxycarbonyl)pιperιdιn-4-yl)oxy-3- trιfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-((4-methoxybenzyl)oxy)-3- cyanophenyl)prop-2-en-1-yl)benzenamιne as a blue solid D In a similar manner, other compounds of formula (AA) are prepared E To 4-(Λ/'-(f-butoxycarbonyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-((4-methoxybenzyl)oxy)-3-cyanophenyl)prop-2-en- 1-yl)benzenamιne (5 2 g) in 80 mL of ethanol was bubbled in HCI gas at -78°C until the solution was saturated The solution was allowed to warm to ambient temperature and stirred for 16 hours The solvent was removed under reduced pressure and the residue was taken up in 80 mL of ethanol Ammonia gas was bubbled into the solution for 4 minutes at -78°C The resulting solution was stirred at 60°C for 1 5 hours and concentrated The resulting residue was separated on HPLC (MeCN/H 2 O, gradient) to afford 4-(pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6- (hydroxy)-3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne after concentration F In a similar manner, other compounds of formula (le) are prepared EXAMPLE 2 (Compounds of formula (If)) A To 4-(pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-(hydroxy)-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne (2 0 g) in 100 mL ethanol/H 2 O (50/50) was added LiOH (0 56 g) at ambient temperature and the resulting solution was stirred at ambient temperature for 4 hours The reaction was acidified with tπfluoroacetic acid, concentrated, separated on HPLC (CH 3 CN/H 2 O, gradient) and freeze-dned to afford 4-(pιperιdιn-4-yl)oxy-3- trιfluoromethyl-A/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6-(hydroxy)-3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne B In a similar manner, other compounds of formula (If) are prepared EXAMPLE 3 (Compounds of formula (Ig)) A To 4-(pιperιdιn-4-yl)oxy-3-tπfluoromethyl-A/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(6-(hydroxy)-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne (2 5 g) and ethyl acetimidate (2 g) in ethanol (100 mL) was added triethylamine and the solution was stirred at ambient temperature for 4 hours The solution was acidified with tnfluoroacetic acid, concentrated, separated on HPLC (CH 3 CN/H 2 O, gradient) and freeze-dπed to afford 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-A/-(2-(carboxy)ethylcarbonyl)-Λ/-(3- (6-(hydroxy)-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne B In a similar manner, other compounds of formula (Ig) are prepared EXAMPLE 4 (Compounds of formula (lb)) A To 4-(pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne (75 mg) in MeOH was added phenyl carbamate (37 mg) and Et 3 N (0 073 mL) The reaction mixture was stirred at ambient temperature for 3 hours, acidified with tnfluoroacetic acid and purified on HPLC (10-40% acetonitrile in water with 0 1 % tnfluoroacetic acid) The corresponding peak was collected and freezed dried to afford 4-(Λ/'-(amιnocarbonyl)pιperιdιn-4-yl)oxy-3- trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne B In a similar manner, other compounds of formula (lb) are prepared EXAMPLE 5 (Compounds of formula (Id)) A To a solution of 4-(pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2- (carboxy )ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne (400 mg) in 100 mL CH 3 CN was added acetyl chloride (500 mg) and Et 3 N (1 28 g) at ambient temperature The resulting solution was stirred at ambient temperature for 2 hours LiOH (500 mg) in water (1 0 mL) was then added to the reaction mixture and the resulting reaction mixture was stirred at ambient temperature for 2 hours Acidification with tnfluoroacetic acid, concentration, purification on HPLC (H 2 O/CH 3 CN, gradient) and freeze-drying afforded 4-(Λ/'-(acetyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2- (carboxy)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne B In a similar manner, other compounds of formula (Id) are prepared EXAMPLE 6 (Compounds of formula (Ih)) A A solution of 4-(Λ/-(f-butoxycarbonyl)pιperιdιn-4-yl)oxybenzenamιne ( 0 6 g, 2 0 mmol) in dimethyl formamide (25 mL) was treated with anhydrous potassium carbonate (0 56 g, 4 1 mmol), sodium iodide (0 61 g, 4 1 mmol), and 3- ((chloromethyl)carbonylamιno)-4-(benzyloxy)benzonιtrιle (0 65 g, 2 15 mmol) and was heated at 80°C for 5 5 hours The reaction was allowed to cool and poured onto ice water The slurry was extracted with ethyl acetate (3x) The combined organic layers were washed with water (2x) and brine, dried and concentrated Purification by flash chromatography on silica gel using a step gradient of 20 and 50% ethyl acetate in hexane gave, after concentration, 1 g of 4-(Λ/"-(f-butoxycarbonyl)pιperιdιn-4-yl)oxy-Λ/-(/V'-(6- benzyloxy-3-cyanophenyl)amιnocarbonyl)methylbenzenamιne, NMR (CDCI 3 , TMS) δ 1 45 (s, 9), 1 66 (m, 2), 1 82 (m, 2), 3 25 (m, 2), 3 68 (m, 2), 3 82 (d, 2), 4 25 (m, 1 ), 4 35 (m, 1 ), 5 02 (s, 2), 6 53 (m, 2), 6 8 (m, 2), 6 9 (d, 1 ), 7 12 (m, 2), 7 28 (m, 4), 8 02 (s, 1 ), 9 58 (s, 1 ) B In a similar manner, other compounds of formula (II) are prepared C A solution of 4-(Λ/"-(f-butoxycarbonyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-benzyloxy- 3-cyanophenyl)amιnocarbonyl)methylbenzenamιne (1g, 1 8 mmol) in absolute ethanol (120 mL) and methylene chloride (20 mL) was placed under a nitrogen atmosphere, cooled in a dry ιce/2-propanol bath, and treated with hydrogen chloride gas until a saturated solution was obtained The flask was sealed with a septum and allowed to warm to ambient temperature overnight Solvent was removed under reduced pressure The residue was dissolved in absolute ethanol, treated with ammonia gas, and heated at reflux for about 4 hours Solvent was removed under reduced pressure Purification by preparative HPLC using a 15-55% gradient of acetonitrile (0 1 % tnfluoroacetic acid) in water (0 1 % tnfluoroacetic acid) gave about 0.3 g of 4-(pιpeπdιn-4-yl)oxy-Λ/-(Λ/'-(6- benzyloxy-3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, NMR (DMSO, TMS) δ 1.76 ( , 2H), 1 95 (m, 2H), 3 05 (m, 2H), 3.22 (m, 2H), 3 82 (s, 2H), 4 41 (m, 1 H), 5 22 (s, 2H), 6 53 (d, 2H), 6 82 (d, 2H), 7 1 (m, 2H), 7 32 (m, 5H), 7 52 (m, 1 H), 8 60 (s, 1 H), 9 02 (s, 1 H), 9 21 (s, 1 H) D In a similar manner, other compounds of formula (Ih) are prepared EXAMPLE 7 (Compounds of formula (lι)) A A solution of 4-(pιpeπdιn-4-yl)oxy-Λ/-(Λ/'-(6-benzyloxy-3- cyanophenyl)amιnocarbonyl)-methylbenzenamιne (0.3 g, 6.3 mmol) in ethanol (25 mL) and triethylamine (5 mL) was treated with ethyl acetimidate hydrochloride (2 g, 16 mmol) and stirred overnight at ambient temperature The reaction was complete by HPLC analysis [15-55% gradient of acetonitrile (0.1 % tnfluoroacetic acid) and water (0 1 % tnfluoroacetic acid)] Solvent was removed under reduced pressure Methanol was added and removed to yield a mixture of compounds of formula (Ii), 4-(N"- (acetyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/-(6-benzyloxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne and 4-(Λ/"-(1 -ιmιnoethyl)pιpeπdιn-4- yl)oxy-Λ/-(Λ/'-(6-benzyloxy-3-amιdιnophenyl)-amιnocarbonyl)methylbenzenamιne B In a similar manner, other compounds of formula (Ii) are prepared EXAMPLE 8 (Compounds of formula (lj)) A A mixture of compounds of formula (Ii), 4-(Λ/"-(acetyl)pιperιdιn-4-yl)oxy-Λ/- (Λ/'-(6-benzyloxy-3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne and 4-(Λ/"-(1- ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-benzyloxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenamine (0 3 g, 5 8 mmol) in a mixture of absolute ethanol (100 mL) and acetic acid (5 mL) was degassed with nitrogen and treated with 10% palladium on carbon (0 3 g, 50% water by wt) The reaction was placed on a Parr Hydrogenator under 43 psi of hydrogen gas for approximately 2 hours Catalyst was removed by filtration and solvent was removed under reduced pressure Purification by preparative HPLC using a 15-55% gradient of acetonitrile (0 1 % tnfluoroacetic acid) and water (0 1 % tnfluoroacetic acid) gave 0 2 g of a compound of formula (Ij) where X is NH, / e , 4-(Λ "-(1 - ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenamine, NMR (DMSO, TMS) δ 1 68 (m, 2), 1 95 (m, 2), 2 23 (s, 3), 3 5 (m, 2), 3 72 (m, 2), 3 82 (s, 2), 4 41 (m, 1 ), 6 57 (d, 2), 6 82 (d, 2), 7 02 (d, 1 ), 7 38 (d, 1 ), 8 56 (s, 1 ), 8 60 (s, 1 ), 8 8 (m, 2), 9 12 (s, 3), 9 21 (s, 1 ), 11 3 (m, 1 ) ppm, Anal (C 22 H 28 N 6 O 3 -H 2 O-3 5C 2 HF 3 O 2 ), and 0 04g of a compound of formula (Ij) where X is O, / e , 4-(Λ/"-(acetyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenamine, NMR (DMSO, TMS) δ 1 48 (m, 2), 1 82 (m, 2), 2 01 (s, 3), 3 2 (m, 2), 3 65 (m, 4), 4 38 (m, 1 ), 6 57 (d, 2), 6 82 (d, 2), 7 02 (d, 1 ), 7 38 (d, 1 ), 8 60 (m, 4), 9 1 (s, 3), 9 42 (s, 1 ), 9 21 (s, 1 ), 1 1 2 (s, 1 ) ppm, Anal (C 22 H 27 N 5 O 4 -1 5H 2 O-2 1 C 2 HF 3 O 2 ) B In a similar manner, other compounds of formula (Ij) are prepared EXAMPLE 9 In methods similar to those described above in Examples 1-8, the following compounds of the invention were prepared 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/-(3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, 4-(pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenamine, 4-(Λ/"-(acetyl)pιperιdιn-4-yl)oxy-Λ/- (Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenamme, 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(amιnocarbonylmethyl)-Λ/-((Λ/'-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(1-(Λ/-(3-amιdιnophenyl)amιnocarbonyl)- ethyl)benzenamιne, 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(ethoxycarbonylmethyl)-Λ/-((Λ/'-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, 4-(Λ/"-(1-ιmιnoethyl)pιpendιn-4-yl)oxy-/V-(methyl)-Λ/-((Λ/-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, 4-(Λ/"-(1 -ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(ethoxycarbonylmethyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)-methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(methyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)-methylbenzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(Λ/-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (Λ/'-(3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1 -ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne,-(Λ/"-(methyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-Λ/-(1-methylethyl)-/V-(Λ/'-(6-benzyloxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(/V"-(methyl)pιperιdιn-4-yl)oxy-Λ/-(1-methylethyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(1-methylethyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(pιpeπdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne,-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne, -(Λ/'-methylpιperιdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)propyl)benzenamιne, -( Λ/'-(1 -ιmιnoethyl)pιpendιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)propyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1 - yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λy-(3-(3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne,-(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1 -yl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(carboxymethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2- en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2- en-1 -yl)-/V-(3-(3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-fluoro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(2-(ethoxycarbonyl)propyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(ethoxycarbonylmethyl)-Λ/-(3- (3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(A/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3,5-dιfluoro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-acetylpιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1 - yl)benzenamιne, -(pιpeπdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne,-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3,5-dιfluoro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(1-methylethyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-fluoro-Λ/-(methoxycarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(methoxycarbonylmethyl)-Λ/-(3- (3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(methyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(amιnocarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-fluoro-Λ/-(amιnocarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-(methoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1 - yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(methoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, -(Λ/'-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-acetyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(methyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-/V-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-((1-methylethyl)carbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop- 2-en-1 -yl)benzenamine; -( N '-(1 -iminoethyl)pipe din-4-yl)oxy-3-trifluoromethyl-Λ/-((1 -methylethyl)carbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1 -yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(pipehdin-4-yl)oxy-3-trifluoromethyl-/V-acetyi-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2- en-1 -yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ '-(methyl)piperidin-4-yl)oxy-3-thfluoromethyl-Λ/-(2-(methoxycarbonyl)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-acetyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(methoxycarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1 -yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-3-carboxy-Λ/-((1-methylethyl)carbonyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(aminocarbonyl)pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-(methoxycarbonyl)-Λ/-(2- (methoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(aminocarbonyl)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methylsulfonyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(A/'-(methylsulfonyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1-methylethyl)carbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1 - yl)benzenamine; -(Λ/'-(methyl)pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(acetyl)piperidin-4-yl)oxy-3-thfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1 -yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(ethoxycarbonyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1 -yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-(nitro)-Λ/-(aminocarbonylmethyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(N -(ethoxy carbonylmethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1 ,2- di(ethoxycarbonyl)ethyl)aminocarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(A/-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-A/-((1 ,2- di(carboxy)ethyl)aminocarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(pipehdin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3-amidinophenyl)prop- 2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-/V-(3-(3- amidinophenyl)prop-2-en-1 -yl)benzenamine; -(Λ/'-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1 ,2- di(ethoxycarbonyl)ethyl)aminocarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(carboxymethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((1,2-di(carboxy)ethyl)aminocarbonyl)- Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(carboxy)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methyl)pipehdin-4-yl)oxy-3-thfluoromethyl-Λ/-((1,2-di(carboxy)ethyl)aminocarbonyl)- Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(acetyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4-di(carboxy)phenyl)carbonyl)-Λ/-(3- (3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/-(methyl)pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4-di(carboxy)phenyl)carbonyl)-Λ/- (3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/'-(methyl)piperidin-4-yl)oxy-3-thfluoromethyl-Λ/-((3,4- dι(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1 - yl)benzenamιne, -(Λ/'-(carboxymethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(carboxymethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((3,4- dι(carboxy)phenyl)carbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(carboxymethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1-yl)- Λ/-(3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-(nιtro)-Λ/-(2-methyl-3-(3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1 - yl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1-yl)benzenamιne, 4-(Λ/-(acetyl)pιperιdιn-4-yl)oxy-W-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-benzyloxy-3-amιdιnophenyl)prop- 2-en-1 -yl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl-3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl- 3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl- 3-(3-amιdιnophenyl)prop-2-en-1 -yl)benzenamιne, 4-(Λ/'-(carboxymethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1-yl)benzenamιne,-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1- yl)benzenamιne, -(Λ '-(actyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-/V-(2- methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1 -yl)benzenamιne, -(Λ/'-(actyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-A/-(2-methyl- 3-(6-hydroxy-3-amιdιnophenyl)prop-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne,-(Λ/'-(acetyl)pιperιdιn-4-yl)oxy-3-methoxy-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne,-(Λ/-(1-ιmmoethyl)pιperιdιn-4-yl)oxy-Λ/-(3-(3-amιdmophenyl)benzyl)benzenamιne,-(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne,-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(ethoxycarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(ethoxycarbonylmethyl)-Λ/-(3- (3-amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-carboxy-/V-(carboxymethyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(ethoxycarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)benzyl)- Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3-amιdιnophenyl)benzyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(tetrahydropyran-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, 4-(thian-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine. EXAMPLE 10 This example illustrates the preparation of representative pharmaceutical compositions for oral administration containing a compound of the invention, or a pharmaceutically acceptable salt thereof: A. Ingredients % wt./wt. Compound of the invention 20.0% Lactose 79.5% Magnesium stearate 0.5% The above ingredients are mixed and dispensed into hard-shell gelatin capsules containing 100 mg each, one capsule would approximate a total daily dosage. B. Ingredients % wt./wt. Compound of the invention 20.0% Magnesium stearate 0.9% Starch 8.6% Lactose 69.6% PVP (polyvinylpyrrolidine) 0.9% The above ingredients with the exception of the magnesium stearate are combined and granulated using water as a granulating liquid. The formulation is then dried, mixed with the magnesium stearate and formed into tablets with an appropriate tableting machine. C. Ingredients Compound of the invention 0.1 g Propylene glycol 20.0 g Polyethylene glycol 400 20.0 g Polysorbate 80 1.0 g Water q.s. 100 mL The compound of the invention is dissolved in propylene glycol, polyethylene glycol 400 and polysorbate 80. A sufficient quantity of water is then added with stirring to provide 100 mL of the solution which is filtered and bottled. D. Ingredients % wt./wt. Compound of the invention 20.0% Peanut Oil 78.0% Span 60 2.0% The above ingredients are melted, mixed and filled into soft elastic capsules. E. Ingredients % wt./wt. Compound of the invention 1.0% Methyl or carboxymethyl cellulose 2.0% 0.9% saline q.s. 100 mL The compound of the invention is dissolved in the cellulose/saline solution, filtered and bottled for use. EXAMPLE 11 This example illustrates the preparation of a representative pharmaceutical formulation for parenteral administration containing a compound of the invention, or a pharmaceutically acceptable salt thereof: Ingredients Compound of the invention 0.02 g Propylene glycol 20.0 g Polyethylene glycol 400 20.0 g Polysorbate 80 1.0 g 0.9% Saline solution q.s. 100 mL The compound of the invention is dissolved in propylene glycol, polyethylene glycol 400 and polysorbate 80. A sufficient quantity of 0.9% saline solution is then added with stirring to provide 100 mL of the I.V. solution which is filtered through a 0.2 m membrane filter and packaged under sterile conditions. EXAMPLE 12 This example illustrates the preparation of a representative pharmaceutical composition in suppository form containing a compound of the invention, or a pharmaceutically acceptable salt thereof: Ingredients % wt /wt Compound of the invention 1 0% Polyethylene glycol 1000 74 5% Polyethylene glycol 4000 24 5% The ingredients are melted together and mixed on a steam bath, and poured into molds containing 2 5 g total weight EXAMPLE 13 This example illustrates the preparation of a representative pharmaceutical formulation for insufflation containing a compound of the invention, or a pharmaceutically acceptable salt thereof Ingredients % wt /wt Micronized compound of the invention 1 0% Micronized lactose 99 0% The ingredients are milled, mixed, and packaged in an insufflator equipped with a dosing pump EXAMPLE 14 This example illustrates the preparation of a representative pharmaceutical formulation in nebulized form containing a compound of the invention, or a pharmaceutically acceptable salt thereof Ingredients % wt /wt Compound of the invention 0 005% Water 89 995% Ethanol 10 000% The compound of the invention is dissolved in ethanol and blended with water The formulation is then packaged in a nebulizer equipped with a dosing pump EXAMPLE 15 This example illustrates the preparation of a representative pharmaceutical formulation in aerosol form containing a compound of the invention, or a pharmaceutically acceptable salt thereof Ingredients % wt /wt Compound of the invention 0 10% Propellant 11/12 98 90% Oleic acid 1 00% The compound of the invention is dispersed in oleic acid and the propellants The resulting mixture is then poured into an aerosol container fitted with a metering valve EXAMPLE 16 (In vitro assay for Factor Xa and Thrombin) This assay demonstrates the activity of the compounds of the invention towards factor Xa, thrombin and tissue plasminogen activator The activities were determined as an initial rate of cleavage of the peptide p-nitroanilide by the enzyme The cleavage product, p-nitroanihne, absorbs at 405 nm with a molar extinction coefficient of 9920 M 'cm 1 Reagents and Solutions Dimethyl sulfoxide (DMSO) (Baker analyzed grade) Assay buffer 50 mM TnsHCI, 150 mM NaCl, 2 5 mM CaCI 2 , and 0 1 % polyethylene glycol 6000, pH 7 5 Enzymes (Enzyme Research Lab ) 1 Human factor Xa stock solution 0 281 mg/mL in assay buffer, stored at -80°C (working solution (2X) 106 ng/mL or 2 nM in assay buffer, prepare prior to use) 2 Human thrombin stock solution Concentration as specified by the supplier, stored at -80°C (working solution (2X) 1200 ng/mL or 32 nM in assay buffer, prepare prior to use) 3 Human tissue plasminogen activator (tPA) (Two chains, Sigma or American Diagnostica Inc ) stock solution Concentration as specified by the supplier, stored at -80°C (working solution (2X) 1361 ng/mL or 20 nM in assay buffer, prepare prior to use) Chromogenic substrates (Pharmacia Hepar Inc ) 1 S2222 (FXa assay) stock solution 6 mM in deionized H 2 0, store at 4°C (working solution (4X) 656 μM in assay buffer) 2. S2302 (Thrombin assay) stock solution: 10 mM in deionized H 2 O, stored at 4°C (working solution (4X): 1200 μM in assay buffer). 3. S2288 (tPA assay) stock solution: 10 mM in deionized H 2 O, stored at 4°C (working solution (4X): 1484 μM in assay buffer for Sigma tPA, or 1120 μM for American Diagnostica tPA). Standard inhibitor compound stock solution: 5 mM in DMSO, stored at -20°C. Test compounds (compounds of the invention) stock solutions: 10 mM in DMSO, stored at -20°C. Assay procedure: Assays were performed in 96-well microtiter plates in a total volume of 200 μl. Assay components were in final concentration of 50 mM TrisHCI, 150 mM NaCl, 2.5 mM CaCI 2 , 0.1% polyethylene glycol 6000, pH 7.5, in the absence or presence of the standard inhibitor or the test compounds and enzyme and substrate at following concentrations: (1 ) 1 nM factor Xa (0.1 nM or 0.2 nM factor Xa for compounds with K,Xa in low picomolar range) and 164 μM S2222; (2) 16 nM thrombin and 300 μM S2302; and (3) 10 nM tPA and 371 μM or 280 μM S2288. Concentrations of the standard inhibitor compound in the assay were from 5 μM to 0.021 μM in 1 to 3 dilution. Concentration of the test compounds in the assay typically were from 10 μM to 0.041 μM in 1 to 3 dilution. For potent test compounds, the concentrations used in the factor Xa assay were further diluted 100 fold (100 nM to 0.41 nM) or 1000 fold (10 nM to 0.041 nM). All substrate concentrations used are equal to their K m values under the present assay conditions. Assays were performed at ambient temperature. The first step in the assay was the preparation of 10 mM test compound stock solutions in DMSO (for potent test compounds, 10 mM stock solutions were further diluted to 0.1 or 0.01 μM for the factor Xa assay), followed by the preparation of test compound working solutions (4X) by a serial dilutions of 10 mM stock solutions with Biomek 1000 in 96 deep well plates as follows: (a) Prepare a 40 μM working solution by diluting the 10 mM stock 1 to 250 in assay buffer in 2 steps: 1 to 100, and 1 to 2.5. (b) Make another five serial dilutions (1 :3) of the 40 μM solution (600 μL for each concentration). A total of six diluted test compound solutions were used in the assay Standard inhibitor compound (5 mM stock) or DMSO (control) went through the same dilution steps as those described above for test compounds The next step in the assay was to dispense 50 μL of the test compound working solutions (4X) (from 40 μM to 0 164 μM) in duplicate to microtiter plates with Biomek To this was added 100 μL of enzyme working solution (2X) with Biomek The resulting solutions were incubated at ambient temperature for 10 minutes To the solutions was added 50 μL of substrate working solution (4X) with Biomek The enzyme kinetics were measured at 405 nm at 10 seconds intervals for five minutes in a THERMOmax plate reader at ambient temperature When a lower concentration of factor Xa was needed in the factor Xa assay, the enzyme kinetics were measured for fifteen minutes (0 2 nM factor Xa) or thirty minutes (0 1 nM factor Xa) at ambient temperature Calculation of K, of the Test compounds Enzyme initial rates were calculated as mOD/min based on the first two minutes readings The IC 50 values were determined by fitting the data to the log-logit equation (linear) or the Morrison equation (non-linear) with an EXCEL spread-sheet K, values were then obtained by dividing the IC 50 by 2 Routinely, K, (factor Xa) values less than 3 nM were calculated from the Morrison equation Compounds of the invention, when tested in this assay, demonstrated the selective ability to inhibit human factor Xa and human thrombin EXAMPLE 17 (In vitro assay for Human Prothrombinase) This assay demonstrates the ability of the compounds of the invention to inhibit prothrombinase Prothrombinase (PTase) catalyzes the activation of prothromb to yield fragment 1 2 plus thrombin with meizothrombin as the intermediate This assay is an end point assay Activity of the prothrombinase is measured by activity of thrombin (one of the reaction products) or by the amount of thrombin formed/time based on a thrombin standard curve (nM vs mOD/min) For determination of IC 50 (PTase) of the compounds of the invention, PTase activity was expressed by thrombin activity (mOD/min) Materials: Enzymes: 1. Human factor Va (Haematologic Technologies Inc., Cat# HCVA-0110) working solution: 1.0 mg/mL in 50% glycerol, 2 mM CaCI 2 , stored at -20°C. 2. Human factor Xa (εnzyme Res. Lab. cat# HFXal 011 ) working solution: 0.281 mg/mL in assay buffer (without BSA), stored at -80°C. 3. Human prothrombin (Fll) (Enzyme Res. Lab., Cat# HP1002) working solution: Diluted Fll to 4.85 mg/mL in assay buffer (without BSA), stored at -80°C. Phospholipid (PCPS) vesicles: PCPS vesicles (80%PC, 20%PS) were prepared by modification of the method reported by Barenholz et al., Biochemistry (1977), Vol. 16, pp. 2806-2810. Phosphatidyl serine (Avanti Polar Lipids, Inc., Cat#840032): 10 mg/mL in chloroform, purified from brain, stored -20°C under nitrogen or argon. Phosphatidyl Choline (Avanti Polar Lipids, Inc., Cat# 850457): 50 mg/ml in chloroform, synthetic 16:0-18:1 Palmitoyl-Oleoyl, stored at -20°C under nitrogen or argon. Spectrozyme-TH (American Diagnostica Inc., Cat# 238L, 50 μmoles, stored at ambient temperature) working solution: Dissolved 50 μmoles in 10 mL dH 2 O. BSA (Sigma Chem Co., Cat# A-7888, FractionV, RIA grade). Assay buffer: 50 mM TrisHCI, pH 7.5, 150 mM NaCl, 2.5 mM CaCI 2 , 0.1 % PEG 6000 (BDH), 0.05% BSA (Sigma, Fr.V, RIA grade). For one plate assay, prepare the following working solutions: 1. Prothrombinase complex: (a) 100 μM PCPS (27.5 μL of PCPS stock (4.36 mM) diluted to final 1200 μL with assay buffer. (b) 25 nM Human factor Va: 5.08 μL of Va stock(1 mg/mL) was diluted to final 1200 μL with assay buffer. (c) 5 pM Human factor Xa: Dilute factor Xa stock (0.281 mg/mL) 1 :1 ,220,000 with assay buffer. Prepare at least 1200 μL. Combine equal volumes (1100 μL) of each component in the order of PCPS, Va and Xa. Use immediately or store in ice (bring to ambient temperature before use). 2 6 μM Human prothrombin (Fll) dilute 124 μL of Fll stock (4 85 mg/mL) to final 1400 μL with assay buffer 3 20 mM EDTA/Assay buffer 0 8 mL of 0 5 M EDTA (pH 8 5) plus 19 2 mL assay buffer 4 0 2 mM Spectrozyme-TH/EDTA buffer 0 44 mL of SPTH stock (5 mM) plus 10 56 mL of 20 mM EDTA/assay buffer 5 Test compounds (compounds of the invention) Prepare a working solution (5X) from 10 mM stock (DMSO) and make a series of 1 3 dilution Compounds were assayed at 6 concentrations in duplicate Assay conditions and procedure Prothrombinase reaction was performed in final 50 μL of mixture containing PTase (20 μM PCPS, 5 nM hFVa, and 1 pM hFXa), 1 2 μM human factor II and varied concentration of the test compounds (5 μM to 0 021 μM or lower concentration range) Reaction was started by addition of PTase and incubated for 6 minutes at ambient temperature Reaction was stopped by addition of EDTA/buffer to final 10 mM Activity of thrombin (product) was then measured in the presence of 0 1 mM of Spectrozyme-TH as substrate at 405 nm for 5 minutes (10 seconds intervals) at ambient temperature in a THEROmax microplate reader Reactions were performed in 96-well microtiter plates In the first step of the assay, 10 μL of diluted test compound (5X) or buffer was added to the plates in duplicate Then 10 μL of prothrombin (hFII) (5X) was added to each well Next 30 μL PTase was added to each well, mix for about 30 seconds The plates were then incubated at ambient temperature for 6 minutes In the next step, 50 μL of 20 mM EDTA (in assay buffer) was added to each well to stop the reaction The resulting solutions were then mixed for about 10 seconds Then 100 μL of 0 2 mM spectrozyme was added to each well The thrombin reaction rate was then measured at 405 nm for 5 minutes at 10 seconds intervals in a Molecular Devices microplate reader Calculations Thrombin reaction rate was expressed as mOD/min using OD readings from the five minute reaction IC 50 values were calculated with the log-logit curve fit program The compounds of the invention demonstrated the ability to inhibit pro-thrombmase when tested in this assay EXAMPLE 18 (In vivo assay) The following assay demonstrates the ability of the compounds to act as anti-coagulants Male rats (250-330 g) were anesthetized with sodium pentobarbital (90 mg/kg, i p ) and prepared for surgery The left carotid artery was cannulated for the measurement of blood pressure as well as for taking blood samples to monitor clotting variables (prothrombin time (PT) and activated partial thromboplastin time (aPTT)) The tail vein was cannulated for the purpose of administering the test compounds (/ e , the compounds of the invention and standards) and the thromboplastin infusion The abdomen was opened via a mid-line incision and the abdominal vena cava was isolated for 2-3 cm distal to the renal vein All venous branches in this 2-3 cm segment of the abdominal vena cava were ligated Following all surgery, the animals were allowed to stabilize prior to beginning the experiment Test compounds were administered as an intravenous bolus (t=0) Three minutes later (t=3), a 5-mιnute infusion of thromboplastin was begun Two minutes into the infusion (t=5), the abdominal vena cava was ligated at both the proximal and distal ends The vessel was left in place for 60 minutes, after which it was excised from the animal, slit open, the clot (if any) carefully removed, and weighed Statistical analysis on the results was performed using a Wilcoxin-matched-pairs signed rank test The compounds of the invention, when tested in this assay, demonstrated the ability to inhibit the clotting of the blood * * * * * While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope of the invention In addition, many modifications may be made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective, spirit and scope of the present invention All such modifications are intended to be within the scope of the claims appended hereto

Claims: WHAT IS CLAIMED IS: A compound of formula (I): wherein: A is -O- or -N(R 7 )-; W is -N(R 4 )-, -S- or -O-; each m is independently 0, 1 , 2, 3 or 4; n is 0 or 1 ; R 1 is hydrogen, alkyl, alkylcarbonyl, phenylalylidenyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, alkoxycarbonyl, phenylcarbonyl (wherein the phenyl group is optionally substituted by carboxy or alkoxycarbonyl), carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), mono[dialkoxycarbonyl]alkylaminocarbonyl, mono[dicarboxy]alkylaminocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylaminosulfonyl; R 2 is -[C(R 7 ) 2 ] m -, -[C(R 7 ) 2 ] m -C(O)-N(R 8 )-, or -[C(R 7 ) 2 ] m -[C(R 8 )]=CH-; or R 2 is R 3 is -C(NH)NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 , R 4 is hydrogen, alkyl, alkylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminosulfonyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, or -C(NH)CH 3 each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, ammo, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl, R 6 is hydrogen, alkyl, hydroxy, alkoxy, aralkoxy (wherein the aryl group is optionally substituted by alkyl, halo or alkoxy), each R 7 and R 8 is independently hydrogen, alkyl, aryl, or aralkyl, and each R 9 is alkyl or aralkyl, as a single stereoisomer or a mixture thereof, or a pharmaceutically acceptable salt thereof 2 The compound of Claim 1 wherein W is -N(R 4 )-, each m is independently 0, 1 or 2, R 2 is -[C(R 7 ) 2 ] m -C(O)-N(R 8 )-, and 3 The compound of Claim 2 selected from the group consisting of the following 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-/v-(Λ/'-(3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, 4-(pιperιdιn-4-yl)oxy-Λ/-(Λ/-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, 4-(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenamine, 4-(Λ/"-(acetyl)pιpendιn-4-yl)oxy-Λ/- (Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)- methylbenzenamine, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(amιnocarbonyimethyl)-Λ/-((A/'-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(1-(Λ/'-(3-amιdιnophenyl)amιnocarbonyl)- ethyl)benzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(ethoxycarbonylmethyl)-Λ/-((Λ/'-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(methyl)-Λ/-((Λ/'-(3- amιdιnophenyl)amιno)carbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(ethoxycarbonylmethyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)-methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(methyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)-methylbenzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (Λ/'-(3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(1-ιrnιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (Λ/'-(6-hydroxy-3-amιdιnophenyl)amιnocarbonyl)methylbenzenamιne,-(Λ/"-(methyl)pιperιdιn-4-yl)oxy-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(Λ '-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-Λ/-(1-methylethyl)-Λ/-(Λ/-(6-benzyloxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-Λ/-(1-methylethyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(1-methylethyl)-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne, and -(Λ/"-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(Λ/'-(6-hydroxy-3- amιdιnophenyl)amιnocarbonyl)methylbenzenamιne 4 The compound of Claim 1 wherein each m is independently 0, 1 or 2, n is 1 , R 2 ιs -[C(R 7 ) 2 ] m -, and R 3 is -C(NH)NH 2 5 The compound of Claim 4 selected from the group consisting of the following 4-(pιperιdιn-4-yl)oxy-/V-(3-(6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne, 4-(Λ/ , -(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne, 4-(Λ/'-methylpιperιdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)propyl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)propyl)benzenamιne, 4-( Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)propyl)benzenamιne, 4-(pιperιdιn-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-/V-(2-methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1 - yl)benzenamιne, 4-(Λ/'-(actyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(2- methyl-3-(6-hydroxy-3-amιdιnophenyl)prop-1 -yl)benzenamιne, and 4-(Λ/'-(actyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl- 3-(6-hydroxy-3-amιdιnophenyl)prop-1-yl)benzenamιne 6 The compound of Claim 1 wherein W is -N(R 4 )-, each m is independently 0, 1 or 2, R 2 ιs -[C(R 7 ) 2 ] m -[C(R 8 )]=CH-, R 3 is -C(NH)NH 2 ; and R 8 is hydrogen. 7. The compound of Claim 6 selected from the group consisting of the following: 4-(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-nitro-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-3-nitro-Λ/-(carboxymethyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(3-amidinophenyl)prop-2-en- 1-yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-ethoxycarbonyl-Λ -(3-(3-amidinophenyl)prop-2-en- 1-yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-ethoxycarbonyl-Λ/-(3-(3-amidinophenyl)prop-2-en- 1 -yl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1 -yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-fluoro-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-Λ/-(2-(ethoxycarbonyl)propyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(piperidin-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; 4-(piperidin-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)-A/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-3-ethoxycarbonyl-Λ/-(ethoxycarbonylmethyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; 4-(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3,5-difluoro-/\/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-acetylpιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-benzyloxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(pιperιdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne,-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3,5-dιfluoro-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(1-methylethyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-fluoro-Λ/-(methoxycarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(methoxycarbonylmethyl)-Λ/-(3- (3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(methyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(amιnocarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-fluoro-Λ-(amιnocarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-nιtro-Λ/-(2-(carboxy)ethylcarbonyl)-A/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-methoxycarbonyl-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-methoxycarbonyl-Λ/-(3-(3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, -(Λ/-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1-yl)benzenamιne, -(Λ/'-(1 -ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-acetyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(methyl)pιpeπdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-((1-methylethyl)carbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop- 2-en-1 -yl)benzenamιne, -( Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((1-methylethyl)carbonyl)-Λ/-(3- (6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-acetyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2- en-1 -yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(acetyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(methoxycarbonyl)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-acetyl-Λ/-(3-(6-hydroxy-3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(1-iminoethyl)pipehdin-4-yl)oxy-3-thfluoromethyl-Λ/-(methoxycarbonyl)-Λ/-(3-(6- hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1 -iminoethyl)pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(benzyl)-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)pipehdin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-/V-((1-methylethyl)carbonyl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(aminocarbonyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-(methoxycarbonyl)-Λ/-(2- (methoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(aminocarbonyl)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methylsulfonyl)pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methylsulfonyl)pipehdin-4-yl)oxy-3-thfluoromethyl-Λ/-((1-methylethyl)carbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/-(methyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/-(acetyl)piperidin-4-yl)oxy-3-thfluoromethyl-Λ/-(2-(ethoxycarbonyl)ethylcarbonyl)-Λ/-(3- (6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/'-(1-iminoethyl)pipe din-4-yl)oxy-3-thfluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amidinophenyl)prop-2-en-1 - yl)benzenamine; 4-(Λ/'-(ethoxycarbonyl)pipehdin-4-yl)oxy-3-thfluoromethyl-Λ/-(3-(6-hydroxy-3- amidinophenyl)prop-2-en-1-yl)benzenamine; 4-(Λ/'-(1 -iminoethyl)piperidin-4-yl)oxy-3-(nitro)-Λ/-(aminocarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-y!)benzenamιne, -(Λ/'-(ethoxycarbonylmethyl)pιperιdιn-4-yl)oxy-3-tπfluoromethyl-Λ/-(2- (ethoxycarbonyl)ethylcarbonyl)-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/-(1 -ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((1 ,2- dι(ethoxycarbonyl)ethyl)amιnocarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((1 ,2- dι(carboxy)ethyl)amιnocarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop- 2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(6- hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(3-(3- amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/-(acetyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((1 ,2- dι(ethoxycarbonyl)ethyl)amιnocarbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/-(acetyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((3,4- dι(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne, -(Λ/'-(carboxymethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(/V'-(acetyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((1 ,2-dι(carboxy)ethyl)amιnocarbonyl)- Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((3,4- dι(carboxy)phenyl)carbonyl)-Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(methyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((1 ,2-dι(carboxy)ethyl)amιnocarbonyl)- Λ/-(3-(3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, 4-(Λ/'-(acetyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-((3,4-dι(carboxy)phenyl)carbonyl)-Λ/-(3- (3-amιdιnophenyl)prop-2-en-1-yl)benzenamιne, -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(/V-(methyl)pipehdin-4-yl)oxy-3-thfluoromethyl-Λ/-((3,4-di(carboxy)phenyl)carbonyl)-Λ/- (3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(methyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(ethoxycarbonyl)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(carboxymethyl)pipehdin-4-yl)oxy-3-thfluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/-(carboxymethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-((3,4- di(carboxy)phenyl)carbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(carboxymethyl)piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(3-amidinophenyl)prop-2- en-1-yl)benzenamine; -(pipehdin-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amidinophenyl)prop-2-en-1-yl)-Λ/-(3-(3- amidinophenyl)prop-2-en-1 -yl)benzenamine; and 4-(piperidin-4-yl)oxy-3-trifluoromethyl-Λ/-(3-(6-benzyloxy-3-amidinophenyl)prop-2-en-1-yl)- Λ/-(3-(6-benzyloxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine. 8. The compound of Claim 1 wherein A is -O-; W is -N(R 4 )-; each m is independently 0, 1 or 2; n is 1 ; R 2 is -[C(R 7 ) 2 ] m -[C(R 8 )]=CH-; R 3 is -C(NH)NH 2 ; and R 8 is methyl. 9. The compound of Claim 8 selected from the group consisting of the following: 4-(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-3-(nitro)-Λ/-(2-methyl-3-(3-amidinophenyl)prop-2-en- 1-yl)benzenamine; -(pipehdin-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(pipehdin-4-yl)oxy-Λ/-(2-methyl-3-(6-benzyloxy-3-amidinophenyl)prop-2-en-1- yl)benzenamine; -(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amidinophenyl)prop-2- en-1 -yl)benzenamine; -(Λ/'-(acetyl)pipehdin-4-yl)oxy-Λ/-(2-methyl-3-(6-hydroxy-3-amidinophenyl)prop-2-en-1 - yl)benzenamine; -(Λ/'-(1-iminoethyl)pipehdin-4-yl)oxy-Λ/-(2-methyl-3-(6-benzyloxy-3-amidinophenyl)prop- 2-en-1 -yl)benzenamine; -(piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl-3-(3- amidinophenyl)prop-2-en-1-yl)benzenamine; -(Λ/'-(1-iminoethyl)piperidin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl- 3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine; -(/V'-(1-iminoethyl)pipehdin-4-yl)oxy-3-carboxy-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/-(2-methyl- 3-(3-amidinophenyl)prop-2-en-1 -yl)benzenamine; and 4-(Λ/'-(carboxymethyl)pipehdin-4-yl)oxy-3-trifluoromethyl-Λ/-(2-(carboxy)ethylcarbonyl)-Λ/- (2-methyl-3-(6-hydroxy-3-amidinophenyl)prop-2-en-1-yl)benzenamine. 10. The compound of Claim 1 wherein A is -O-; W is -N(R 4 )-; each m is independently 0, 1 or 2; n is 1 ; R 2 is and R 3 is -C(NH)NH 2 . 11. The compound of Claim 12 selected from the group consisting of the following: 4-(Λ/-(1-iminoethyl)piperidin-4-yl)oxy-3-nitro-Λ/-(3-(3-amidinophenyl)benzyl)benzenamine; -(Λ/'-(acetyl)pιperιdιn-4-yl)oxy-3-methoxy-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne,-(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-/V-(3-(3-amιdιnophenyl)benzyl)benzenamιne,-(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne,-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(ethoxycarbonylmethyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιpeπdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(ethoxycarbonylmethyl)-Λ/-(3- (3-amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmmoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(carboxymethyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne, -(pιperιdιn-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-trιfluoromethyl-/V-(ethoxycarbonylmethyl)-/V-(3-(3- amιdtnophenyl)benzyl)benzenamιne, -(Λ/'-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-(ethoxycarbonyl)-Λ/-(3-(3-amιdιnophenyl)benzyl)- Λ/-(3-(3-amιdιnophenyl)benzyl)benzenamιne, and 4-(Λ/-(1-ιmιnoethyl)pιperιdιn-4-yl)oxy-3-carboxy-Λ/-(3-(3-amιdιnophenyl)benzyl)-Λ/-(3-(3- amιdιnophenyl)benzyl)benzenamιne 12 The compound of Claim 1 wherein each m is independently 0, 1 or 2, R 2 is -[C(R 7 ) 2 ] m -[C(R 8 )]=CH-, and 13 The compound of Claim 14 selected from the group consisting of the following 4-(tetrahydropyran-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en- 1-yl)benzenamιne, and 4-(thιan-4-yl)oxy-3-trιfluoromethyl-Λ/-(3-(6-hydroxy-3-amιdιnophenyl)prop-2-en-1- yl)benzenamιne 14 A pharmaceutical composition useful in treating a human having a disease- state characterized by thrombotic activity, which composition comprises a therapeutically effective amount of a compound of formula (I) wherein W is -N(R 4 )-, -S- or -O-, each m is independently 0, 1 , 2, 3 or 4, R 1 is hydrogen, alkyl, alkylcarbonyl, phenylalylidenyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, alkoxycarbonyl, phenylcarbonyl (wherein the phenyl group is optionally substituted by carboxy or alkoxycarbonyl), carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), mono[dιalkoxycarbonyl]alkylamιnocarbonyl, mono[dιcarboxy]alkylamιnocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylaminosulfonyl, R 2 is -[C(R 7 ) 2 ] m -, -[C(R 7 ) 2 ] m -C(O)-N(R 8 )-, or -[C(R 7 ) 2 ] m -[C(R 8 )]=CH- or R 2 is R 3 is -C(NH)NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ; R 4 is hydrogen, alkyl, alkylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminosulfonyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, or -C(NH)CH 3 . each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, amino, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl; R 6 is hydrogen, alkyl, hydroxy, alkoxy, aralkoxy (wherein the aryl group is optionally substituted by alkyl, halo or alkoxy); each R 7 and R 8 is independently hydrogen, alkyl, aryl, or aralkyl; and each R 9 is alkyl or aralkyl; as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. 15. A method of treating a human having a disease-state characterized by thrombotic acitivity, which method comprises administering to a human in need thereof a therapeutically effective amount of a compound of formula (I): wherein: A is -O- or -N(R 7 )-; W is -N(R 4 )-, -S- or -O-; each m is independently 0, 1 , 2, 3 or 4, R 1 is hydrogen, alkyl, alkylcarbonyl, phenylalylidenyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), alkoxycarbonylalkyl, carboxyalkyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, alkoxycarbonyl, phenylcarbonyl (wherein the phenyl group is optionally substituted by carboxy or alkoxycarbonyl), carboxyalkylcarbonyl, alkoxycarbonylalkylcarbonyl, aminocarbonylalkylcarbonyl, benzyl (wherein the phenyl group is optionally substituted by alkyl, halo, alkoxy, aralkoxy, -C(NH)-NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 ), mono[dιalkoxycarbonyl]alkylamιnocarbonyl, mono[dιcarboxy]alkylamιnocarbonyl, alkylsulfonyl, arylsulfonyl or dialkylaminosulfonyl, R 2 is -[C(R 7 ) 2 ] m -, -[C(R 7 ) 2 ] m -C(O)-N(R 8 )-, or -[C(R 7 ) 2 ] m -[C(R 8 )]=CH- > R 3 is -C(NH)NH 2 , -C(NH)N(H)OR 7 , -C(NH)N(H)C(O)OR 9 , -C(NH)N(H)C(O)R 9 , -C(NH)N(H)S(O) 2 R 9 , or -C(NH)N(H)C(O)N(H)R 7 , R 4 is hydrogen, alkyl, alkylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminosulfonyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, or -C(NH)CH 3 each R 5 is independently hydrogen, alkyl, halo, haloalkyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, ammo, monoalkylamino, dialkylamino, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl, R 6 is hydrogen, alkyl, hydroxy, alkoxy, aralkoxy (wherein the aryl group is optionally substituted by alkyl, halo or alkoxy), each R 7 and R 8 is independently hydrogen, alkyl, aryl, or aralkyl, and each R 9 is alkyl or aralkyl, as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof.

Inventors: GUILFORD WILLIAM J, SAKATA STEVEN T, SHAW KENNETH J, WU SHUNG, XU WEI, ZHAO ZUCHUN, GUILFORD, WILLIAM, J., SAKATA, STEVEN, T., SHAW, KENNETH, J., WU, SHUNG, XU, WEI, ZHAO, ZUCHUN
Applicants: BERLEX LAB, GUILFORD WILLIAM J, SAKATA STEVEN T, SHAW KENNETH J, WU SHUNG, XU WEI, ZHAO ZUCHUN, BERLEX LABORATORIES, INC., GUILFORD, WILLIAM, J., SAKATA, STEVEN, T., SHAW, KENNETH, J., WU, SHUNG, XU, WEI, ZHAO, ZUCHUN
Application year: 2000
Main classification: C07D211
IPC codes: A61K31, A61P7, A61P43, C07D211, C07D309, C07D335