NEISSERIAL ANTIGENIC PEPTIDES

Abstract: This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria <i>Neisseria meningitidis</i> B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto <i>e.g.</i>, antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

Description: NEISSERIAL ANTIGENIC PEPTIDES All documents cited herein are incorporated by reference in their entirety. TECHNICAL FIELD This invention relates to antigenic peptide sequences from the bacteria Neisseria meningitidis and Neisseria gonorrhoea. BACKGROUND ART N. meningitidis is a non-motile, Gram-negative diplococcus that is pathogenic in humans. Based on the organism's capsular polysaccharide, 12 serogroups of N. meningitidis have been identified. Group A is the pathogen most often implicated in epidemic disease in sub-Saharan Africa. Serogroups B and C are responsible for the vast majority of cases in the United States and in most developed countries. Serogroups W135 and Y are responsible for the rest of the cases in the United States and developed countries. The meningococcal vaccine currently in use is a tetravalent polysaccharide vaccine composed of serogroups A, C, Y and W135. Meningococcus B remains a problem, however. The polysaccharide approach cannot be used because the menB capsular polysaccharide is a polymer of α(2-8)-linked N-acetyl neuraminic acid that is also present in mammalian tissue. One approach to a menB vaccine uses mixtures of outer membrane proteins (OMPs) To overcome the antigenic variability, multivalent vaccines containing up to nine different porins have been constructed [e.g., Poolman JT (1992) Development of a meningococcal vaccine. Infect. Agents Dis. 4: 13-28]. Additional proteins to be used in outer membrane vaccines have been the opa and ope proteins, but none of these approaches have been able to overcome the antigenic variability [e.g., Ala'Aldeen & Borriello (1996)]. The meningococcal transferrin-binding proteins 1 and 2 are both surface exposed and generate bactericidal antibodies capable of killing homologous and heterologous strains. [Vaccine 14(l):49-53]. DISCLOSURE OF THE INVENTION The invention provides fragments of the proteins disclosed in international patent applications WO99/57280 and WOOO/22430 (the "International Applications"), wherein the fragments comprise at least one antigenic determinant. Thus, if the length of any particular protein sequence disclosed in the International Applications is x amino acids, the present invention provides fragments of at most x-1 amino acids of that protein. The fragment may be shorter than this (e.g., x-2, x-3, x-4, ...), and is preferably 100 amino acids or less (e.g., 90 amino acids, 80 amino acids etc.). The fragment may be as short as 3 amino acids, but is preferably longer (e.g., up to 5, 6, 7, 8, 9, 10, 12, 15, 20, 25, 30, 35, 40, 50, 75, or 100 amino acids). Preferred fragments comprise the meningococcal peptide sequences disclosed in Table 1, or sub-sequences thereof. The fragments may be longer than those given in Table 1 e.g., where a fragment in Table 1 runs from amino acid residue p to residue q of a protein, the invention also relates to fragments from residue (p-I), (p-2), or (p-3) to residue (q+1), (q+2), or (q+3). The invention also provides polypeptides that are homologous (i.e., have sequence identity) to these fragments. Depending on the particular fragment, the degree of sequence identity is preferably greater than 50% (e.g., 60%, 70%, 80%, 90%, 95%, 99% or more). These homologous polypeptides include mutants and allelic variants of the fragments. Identity between the two sequences is preferably determined by the Smith- Waterman homology search algorithm as implemented in the MPSRCH program (Oxford Molecular), using an affine gap search with parameters gap open penalty=\2 and gap extension penalty=l. The invention also provides proteins comprising one or more of the above-defined fragments. The invention is subject to the proviso that it does not include within its scope proteins limited to any of the full length protein sequences disclosed in the International Applications (i.e., the even SEQ IDs: 2-3020 of WO99/57280 and the odd SEQ IDs: 963-1045 of WO00/22430). The proteins of the invention can, of course, be prepared by various means (e.g., recombinant expression, purification from cell culture, chemical synthesis etc.) and in various forms (e.g., native, C-terminal and/or N-terminal fusions etc.). They are preferably prepared in substantially pure form (i.e., substantially free from other Neisserial or host cell proteins). Short proteins are preferably produced using chemical peptide synthesis. According to a further aspect, the invention provides antibodies which recognise the fragments of the invention, with the proviso that the invention does not include within its scope antibodies which recognise any of the complete protein sequences in the International Applications. The antibodies may be polyclonal or monoclonal, and may be produced by any suitable means. The invention also provides proteins comprising peptide sequences recognised by these antibodies. These peptide sequences will, of course, include fragments of the meningococcal proteins in the International Applications, but will also include peptides that mimic the antigenic structure of the meningococcal peptides when bound to immunoglobulin. According to a further aspect, the invention provides nucleic acid encoding the fragments and proteins of the invention, with the proviso that the invention does not include within its scope nucleic acid encoding any of the full length protein sequences in the International Applications. The nucleic acids may be as short as 10 nucleotides, but are preferably longer (e.g., up to 10, 12, 15, , 18, 20, 25, 30, 35, 40, 50, 75, or 100 nucleotides). In addition, the invention provides nucleic acid comprising sequences homologous (i.e., having sequence identity) to these sequences. The degree of sequence identity is preferably greater than 50% (e.g., 60%, 70%, 80%, 90%, 95%, 99% or more). Furthermore, the invention provides nucleic acid which can hybridise to these sequences, preferably under "high stringency" conditions (e.g., 65°C in a O.lxSSC, 0.5% SDS solution). It should also be appreciated that the invention provides nucleic acid comprising sequences complementary to those described above (e.g., for antisense or probing purposes). Nucleic acid according to the invention can, of course, be prepared in many ways (e.g., by chemical synthesis, from genomic or cDNA libraries, from the organism itself etc.) and can take various forms (e.g., single stranded, double stranded, vectors, probes etc.). In addition, the term "nucleic acid" includes DNA and RNA, and also their analogues, such as those containing modified backbones, and also peptide nucleic acids (PNA), etc. According to a further aspect, the invention provides vectors comprising nucleotide sequences of the invention (e.g., expression vectors) and host cells transformed with such vectors. According to a further aspect, the invention provides compositions comprising protein, antibody, and/or nucleic acid according to the invention. These compositions may be suitable as vaccines, for instance, or as diagnostic reagents, or as immunogenic compositions. The invention also provides nucleic acid, protein, or antibody according to the invention for use as medicaments (e.g., as vaccines or as immunogenic compositions) or as diagnostic reagents. It also provides the use of nucleic acid, protein, or antibody according to the invention in the manufacture of: (i) a medicament for treating or preventing infection due to Neisserial bacteria; (ii) a diagnostic reagent for detecting the presence of Neisserial bacteria or of antibodies raised against Neisserial bacteria; and/or (iii) a reagent which can raise antibodies against Neisserial bacteria. Said Neisserial bacteria may be any species or strain (such as N. gonorrhoeae) but are preferably N. meningitidis, especially strain A or strain B. The invention also provides a method of treating a patient, comprising administering to the patient a therapeutically effective amount of nucleic acid, protein, and/or antibody according to the invention. According to further aspects, the invention provides various processes, for example: A process for producing proteins of the invention is provided, comprising the step of culturing a host cell according to the invention under conditions which induce protein expression; A process for producing protein or nucleic acid of the invention is provided, wherein the protein or nucleic acid is synthesised in part or in whole using chemical means; A process for detecting polynucleotides of the invention is provided, comprising the steps of: (a) contacting a nucleic probe according to the invention with a biological sample under hybridizing conditions to form duplexes; and (b) detecting said duplexes; and A process for detecting proteins of the invention is provided, comprising the steps of: (a) contacting an antibody according to the invention with a biological sample under conditions suitable for the formation of an antibody-antigen complexes; and (b) detecting said complexes. A summary of standard techniques and procedures which may be employed in order to perform the invention (e.g., to utilise the disclosed sequences for vaccination or diagnostic purposes) follows. This summary is not a limitation on the invention but, rather, gives examples which may be used, but which are not required. General The practice of the present invention w ill em ploy, unless otherwise indicated, conventional techniques of m olecular biology, m icrobiology, recom binant D N A , and im m unology, w hich are w ithin the skill of the art. Such techniques are explained fully in the literature e.g., Sam brook Molecular Cloning; A laboratory Manual, Second Edition (1989); DNA Cloning, Volumes I and ii (D .N G lover ed. 1985); Oligonucleotide Synthesis (M .J. G ait ed, 1984); Nucleic Acid Hybridization (B .D . Ha es & S .J. H iggins eds. 1984); Transcription and Translation (B .D . Hames & S.J. Higgins eds. 1984); Animal Cell Culture (R .I. Freshney ed. 1986); Immobilized Cells and Enzymes (IR L Press, 1986); B . Perbal, A Practical Guide to Molecular Cloning ( 1984); the Methods in Enzymology series (Academ ic Press, Inc.), especially volum es 154 & 155 ; Gene Transfer Vectors for Mammalian Cells (J.H . M iller and M .P. Calos eds. 1987, Cold Spring Harbor Laboratory); M ayer and W alker, eds. (1987), Immunochemical Methods in Cell and Molecular Biology (Academ ic Press, London); Scopes, (1987) Protein Purification: Principles and Practice, Second Edition (Springer-Verlag, N.Y.), and Handbook of Experimental Immunology, Volumes I-IV (D.M. Weir and C. C. Blackwell eds 1986). Standard abbreviations for nucleotides and amino acids are used in this specification. All publications, patents, and patent applications cited herein are incorporated in full by reference. Definitions A composition containing X is "substantially free of" Y when at least 85% by weight of the total X+Y in the composition is X. Preferably, X comprises at least about 90% by weight of the total of X+Y in the composition, more preferably at least about 95% or even 99% by weight. The term "comprising" means "including" as well as "consisting" e.g., a composition "comprising" X may consist exclusively of X or may include something additional to X, such as X + Y. The term "antigenic determinant" includes B-cell epitopes and T-cell epitopes. The term "heterologous" refers to two biological components that are not found together in nature. The components may be host cells, genes, or regulatory regions, such as promoters. Although the heterologous components are not found together in nature, they can function together, as when a promoter heterologous to a gene is operably linked to the gene. Another example is where a meningococcal sequence is heterologous to a mouse host cell. A further examples would be two epitopes from the same or different proteins which have been assembled in a single protein in an arrangement not found in nature. An "origin of replication" is a polynucleotide sequence that initiates and regulates replication of polynucleotides, such as an expression vector. The origin of replication behaves as an autonomous unit of polynucleotide replication within a cell, capable of replication under its own control. An origin of replication may be needed for a vector to replicate in a particular host cell. With certain origins of replication, an expression vector can be reproduced at a high copy number in the presence of the appropriate proteins within the cell. Examples of origins are the autonomously replicating sequences, which are effective in yeast; and the viral T-antigen, effective in COS-7 cells. Expression systems The meningococcal nucleotide sequences can be expressed in a variety of different expression systems; for example those used with mammalian cells, baculoviruses, plants, bacteria, and yeast. i. Mammalian Systems Mammalian expression systems are known in the art. A mammalian promoter is any DNA sequence capable of binding mammalian RNA polymerase and initiating the downstream (3') transcription of a coding sequence (e.g., structural gene) into mRNA. A promoter will have a transcription initiating region, which is usually placed proximal to the 5' end of the coding sequence, and a TATA box, usually located 25-30 base pairs (bp) upstream of the transcription initiation site. The TATA box is thought to direct RNA polymerase II to begin RNA synthesis at the correct site. A mammalian promoter will also contain an upstream promoter element, usually located within 100 to 200 bp upstream of the TATA box. An upstream promoter element determines the rate at which transcription is initiated and can act in either orientation [Sambrook et al. (1989) "Expression of Cloned Genes in Mammalian Cells." In Molecular Cloning: A Laboratory Manual, 2nd ed.]. Mammalian viral genes are often highly expressed and have a broad host range; therefore sequences encoding mammalian viral genes provide particularly useful promoter sequences. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter (Ad MLP), and herpes simplex virus promoter. In addition, sequences derived from non-viral genes, such as the murine metallotheionein gene, also provide useful promoter sequences. Expression may be either constitutive or regulated (inducible), depending on the promoter can be induced with glucocorticoid in hormone-responsive cells. The presence of an enhancer element (enhancer), combined with the promoter elements described above, will usually increase expression levels. An enhancer is a regulatory DNA sequence that can stimulate transcription up to 1000-fold when linked to homologous or heterologous promoters, with synthesis beginning at the normal RNA start site. Enhancers are also active when they are placed upstream or downstream from the transcription initiation site, in either normal or flipped orientation, or at a distance of more than 1000 nucleotides from the promoter [Maniatis et al. (1987) Science 2J5.1237; Alberts et al. (1989) Molecular Biology of the Cell, 2nd ed.]. Enhancer elements derived from viruses may be particularly useful, because they usually have a broader host range. Examples include the SV40 early gene enhancer [Dijkema et al (1985) EMBO J. 4:761 ] and the enhancer/promoters derived from the long terminal repeat (LTR) of the Rous Sarcoma Virus [Gorman et al. (1982b) Proc. Natl. Acad. Sci.79:6111] and from human cytomegalovirus [Boshart et al. (1985) Cell 41:521], Additionally, some enhancers are regulatable and become active only in the presence of an inducer, such as a hormone or metal ion [Sassone-Corsi and Borelli (1986) Trends Genet.2:215; Maniatis etal. (1987) Science 236:1237]. A DNA molecule may be expressed intracellularly in mammalian cells. A promoter sequence may be directly linked with the DNA molecule, in which case the first amino acid at the N-terminus of the recombinant protein will always be a methionine, which is encoded by the ATG start codon. If desired, the N-terminus may be cleaved from the protein by in vitro incubation with cyanogen bromide. Alternatively, foreign proteins can also be secreted from the cell into the growth media by creating chimeric DNA molecules that encode a fusion protein comprised of a leader sequence fragment that provides for secretion of the foreign protein in mammalian cells. Preferably, there are processing sites encoded between the leader fragment and the foreign gene that can be cleaved either in vivo or in vitro. The leader sequence fragment usually encodes a signal peptide comprised of hydrophobic amino acids which direct the secretion of the protein from the cell. The adenovirus triparite leader is an example of a leader sequence that provides for secretion of a foreign protein in mammalian cells. Usually, transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3' to the translation stop codon and thus, together with the promoter elements, flank the coding sequence. The 3' terminus of the mature mRNA is formed by site-specific post-transcriptional cleavage and polyadenylation [Birnstiel et al. (1985) Cell 47:349; Proudfoot and Whitelaw (1988) "Termination and 3' end processing of eukaryotic RNA. In Transcription and splicing (ed. B.D. Hames and D.M. Glover); Proudfoot (1989) Trends Biochem. Sci.74:105]. These sequences direct the transcription of an mRNA which can be translated into the polypeptide encoded by the DNA. Examples of transcription terminater/polyadenylation signals include those derived from SV40 [Sambrook et al (1989) "Expression of cloned genes in cultured mammalian cells." In Molecular Cloning: A Laboratory Manual], Usually, the above described components, comprising a promoter, polyadenylation signal, and transcription termination sequence are put together into expression constructs. Enhancers, introns with functional splice donor and acceptor sites, and leader sequences may also be included in an expression construct, if desired. Expression constructs are often maintained in a replicon, such as an extrachromosomal element {e.g., plasmids) capable of stable maintenance in a host, such as mammalian cells or bacteria. Mammalian replication systems include those derived from animal viruses, which require trans-acting factors to replicate. For example, plasmids containing the replication systems of papovaviruses, such as SV40 [Gluzman (1981) Cell 25:175] or polyomavirus, replicate to extremely high copy number in the presence of the appropriate viral T antigen. Additional examples of mammalian replicons include those derived from bovine papillomavirus and Epstein-Barr virus. Additionally, the replicon may have two replicaton systems, thus allowing it to be maintained, for example, in mammalian cells for expression and in a prokaryotic host for cloning and amplification. Examples of such mammalian-bacteria shuttle vectors include pMT2 [Kaufman et al. (1989) Mol. Cell. Biol.9:946] and pHEBO [Shi izu et al. (1986) Mol. Cell. Biol.6:1074]. The transformation procedure used depends upon the host to be transformed. Methods for introduction of heterologous polynucleotides into mammalian cells are known in the art and include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DNA into nuclei. Mammalian cell lines available as hosts for expression are known in the art and include many immortalized cell lines available from the American Type Culture Collection (ATCC), including but not limited to, Chinese hamster ovary (CHO) cells, HeLa cells, baby hamster kidney (BHK) cells, monkey kidney cells (COS), human hepatocellular carcinoma cells {e.g., Hep G2), and a number of other cell lines. ii. Baculovirus Systems The polynucleotide encoding the protein can also be inserted into a suitable insect expression vector, and is operably linked to the control elements within that vector. Vector construction employs techniques which are known in the art. Generally, the components of the expression system include a transfer vector, usually a bacterial plasmid, which contains both a fragment of the baculovirus genome, and a convenient restriction site for insertion of the heterologous gene or genes to be expressed; a wild type baculovirus with a sequence homologous to the baculovirus-specific fragment in the transfer vector (this allows for the homologous recombination of the heterologous gene in to the baculovirus genome); and appropriate insect host cells and growth media. After inserting the DNA sequence encoding the protein into the transfer vector, the vector and the wild type viral genome are transfected into an insect host cell where the vector and viral genome are allowed to recombine. The packaged recombinant virus is expressed and recombinant plaques are identified and purified. Materials and methods for baculovirus/insect cell expression systems are commercially available in kit form from, inter alia, Invitrogen, San Diego CA ("MaxBac" kit). These techniques are generally known to those skilled in the art and fully described in Summers and Smith, Texas Agricultural Experiment Station Bulletin No.1555 (1987) (hereinafter "Summers and Smith"). Prior to inserting the DNA sequence encoding the protein into the baculovirus genome, the above described components, comprising a promoter, leader (if desired), coding sequence of interest, and transcription termination sequence, are usually assembled into an intermediate transplacement construct (transfer vector). This construct may contain a single gene and operably linked regulatory elements; multiple genes, each with its owned set of operably linked regulatory elements; or multiple genes, regulated by the same set of regulatory elements. Intermediate transplacement constructs are often maintained in a replicon, such as an extrachromosomal element (e.g., plasmids) capable of stable maintenance in a host, such as a bacterium. The replicon will have a replication system, thus allowing it to be maintained in a suitable host for cloning and amplification. Currently, the most commonly used transfer vector for introducing foreign genes into AcNPV is pAc373. Many other vectors, known to those of skill in the art, have also been designed. These include, for example, pVL985 (which alters the polyhedrin start codon from ATG to ATT, and which introduces a BamHI cloning site 32 basepairs downstream from the ATT; see Luckow and Summers, Virology (1989) / 7:31. The plasmid usually also contains the polyhedrin polyadenylation signal (Miller et al. (1988) Ann. Rev. MicrobioL, 42:177) and a prokaryotic ampicillin-resistance {amp) gene and origin of replication for selection and propagation in E. coli. Baculovirus transfer vectors usually contain a baculovirus promoter. A baculovirus promoter is any DNA sequence capable of binding a baculovirus RNA polymerase and initiating the downstream (5' to 3') transcription of a coding sequence (e.g., structural gene) into mRNA. A promoter will have a transcription initiation region which is usually placed proximal to the 5' end of the coding sequence. This transcription initiation region usually includes an RNA polymerase binding site and a transcription initiation site. A baculovirus transfer vector may also have a second domain called an enhancer, which, if present, is usually distal to the structural gene. Expression may be either regulated or constitutive. Structural genes, abundantly transcribed at late times in a viral infection cycle, provide particularly useful promoter sequences. Examples include sequences derived from the gene encoding the viral polyhedron protein, Friesen et al., (1986) "The Regulation of Baculovirus Gene Expression," in: The Molecular Biology of Baculoviruses (ed. Walter Doerfler); EPO Publ. Nos.127839 and 155476; and the gene encoding the plO protein, Vlak et al., (1988), J. Gen. Virol.69:165. DNA encoding suitable signal sequences can be derived from genes for secreted insect or baculovirus proteins, such as the baculovirus polyhedrin gene (Carbonell et al. (1988) Gene, 73:409). Alternatively, since the signals for mammalian cell posttranslational modifications (such as signal peptide cleavage, proteolytic cleavage, and phosphorylation) appear to be recognized by insect cells, and the signals required for secretion and nuclear accumulation also appear to be conserved between the invertebrate cells and vertebrate cells, leaders of non-insect origin, such as those derived from genes encoding human D-interferon, Maeda et al., (1985), Nature 315:592; human gastrin-releasing peptide, Lebacq-Verheyden et al., (1988), Molec. Cell. Biol. 8:3129; human IL-2, Smith et al„ (1985) Proc. Nat'l Acad. Sci. USA, 82:8404; mouse IL-3, (Miyajima et al., (1987) Gene 58:273; and human glucocerebrosidase, Martin et al. (1988) DNA, 7:99, can also be used to provide for secretion in insects. A recombinant polypeptide or polyprotein may be expressed intracellularly or, if it is expressed with the proper regulatory sequences, it can be secreted. Good intracellular expression of nonfused foreign proteins usually requires heterologous genes that ideally have a short leader sequence containing suitable translation initiation signals preceding an ATG start signal. If desired, methionine at the N-terminus may be cleaved from the mature protein by in vitro incubation with cyanogen bromide. Alternatively, recombinant polyproteins or proteins which are not naturally secreted can be secreted from the insect cell by creating chimeric DNA molecules that encode a fusion protein comprised of a leader sequence fragment that provides for secretion of the foreign protein in insects. The leader sequence fragment usually encodes a signal peptide comprised of hydrophobic amino acids which direct the translocation of the protein into the endoplasmic reticulum. After insertion of the DNA sequence and/or the gene encoding the expression product precursor of the protein, an insect cell host is co-transformed with the heterologous DNA of the transfer vector and the genomic DNA of wild type baculovirus -- usually by co-transfection. The promoter and transcription termination sequence of the construct will usually comprise a 2-5kb section of the baculovirus genome. Methods for introducing heterologous DNA into the desired site in the baculovirus virus are known in the art. (See Summers and Smith supra; Ju et al. (1987); Smith et al., Mol. Cell. Biol. (1983) 3:2156; and Luckow and Summers (1989)). For example, the insertion can be into a gene such as the polyhedrin gene, by homologous double crossover recombination; insertion can also be into a restriction enzyme site engineered into the desired baculovirus gene. Miller et al., (1989), Bioessays 4:91. The DNA sequence, when cloned in place of the polyhedrin gene in the expression vector, is flanked both 5' and 3' by polyhedrin-specific sequences and is positioned downstream of the polyhedrin promoter. The newly formed baculovirus expression vector is subsequently packaged into an infectious recombinant baculovirus. Homologous recombination occurs at low frequency (between about 1% and about 5%); thus, the majority of the virus produced after cotransfection is still wild-type virus. Therefore, a method is necessary to identify recombinant viruses. An advantage of the expression system is a visual screen allowing recombinant viruses to be distinguished. The polyhedrin protein, which is produced by the native virus, is produced at very high levels in the nuclei of infected cells at late times after viral infection. Accumulated polyhedrin protein forms occlusion bodies that also contain embedded particles. These occlusion bodies, up to 15 Dm in size, are highly refractile, giving them a bright shiny appearance that is readily visualized under the light microscope. Cells infected with recombinant viruses lack occlusion bodies. To distinguish recombinant virus from wild- type virus, the transfection supernatant is plaqued onto a monolayer of insect cells by techniques known to those skilled in the art. Namely, the plaques are screened under the light microscope for the presence (indicative of wild-type virus) or absence (indicative of recombinant virus) of occlusion bodies. "Current Protocols in Microbiology" Vol.2 (Ausubel et al. eds) at 16.8 (Supp.10, 1990); Summers and Smith, supra; Miller et al. (1989). Recombinant baculovirus expression vectors have been developed for infection into several insect cells. For example, recombinant baculoviruses have been developed for, inter alia: Aedes aegypti , Autographa californica, Bombyx mori, Drosophila melanogaster, Spodoptera frugiperda, and Trichoplusia ni (WO 89/046699; Carbonell et al., (1985) J. Virol.56:153; Wright (1986) Nature 327:718; Smith et al., (1983) Mol. Cell. Biol.3:2156; and see generally, Fraser, et al. (1989) In Vitro Cell. Dev. Biol.25:225). Cells and cell culture media are commercially available for both direct and fusion expression of heterologous polypeptides in a baculovirus/expression system; cell culture technology is generally known to those skilled in the art. See, e.g., Summers and Smith supra. The modified insect cells may then be grown in an appropriate nutrient medium, which allows for stable maintenance of the plasmid(s) present in the modified insect host. Where the expression product gene is under inducible control, the host may be grown to high density, and expression induced. Alternatively, where expression is constitutive, the product will be continuously expressed into the medium and the nutrient medium must be continuously circulated, while removing the product of interest and augmenting depleted nutrients. The product may be purified by such techniques as chromatography, e.g., HPLC, affinity chromatography, ion exchange chromatography, etc.; electrophoresis; density gradient centrifugation; solvent extraction, or the like. As appropriate, the product may be further purified, as required, so as to remove substantially any insect proteins which are also secreted in the medium or result from lysis of insect cells, so as to provide a product which is at least substantially free of host debris, e.g., proteins, lipids and polysaccharides. In order to obtain protein expression, recombinant host cells derived from the transformants are incubated under conditions which allow expression of the recombinant protein encoding sequence. These conditions will vary, dependent upon the host cell selected. However, the conditions are readily ascertainable to those of ordinary skill in the art, based upon what is known in the art. iii. Plant Systems There are many plant cell culture and whole plant genetic expression systems known in the art. Exemplary plant cellular genetic expression systems include those described in patents, such as: US 5,693,506; US 5,659,122; and US 5,608,143. Additional examples of genetic expression in plant cell culture has been described by Zenk, Phy to chemistry 30:3861-3863 (1991). Descriptions of plant protein signal peptides may be found in addition to the references described above in Vaulcombe et al., Mol. Gen. Genet.209:33-40 (1987); Chandler et al„ Plant Molecular Biology 3:407-418 (1984); Rogers, J. Biol. Chem.260:3731-3738 (1985); Rothstein et al., Gene 55:353-356 (1987); Whittier et al., Nucleic Acids Research 15:2515-2535 (1987); Wirsel et al., Molecular Microbiology 3:3-14 (1989); Yu et al., Gene 122:247-253 (1992). A description of the regulation of plant gene expression by the phytohormone, gibberellic acid and secreted enzymes induced by gibberellic acid can be found in R.L. Jones and J. MacMillin, Gibberellins: in: Advanced Plant Physiology,. Malcolm B. Wilkins, ed., 1984 Pitman Publishing Limited, London, pp.21-52. References that describe other metabolically-regulated genes: Sheen, Plant Cell, 2:1027-1038(1990); Maas et al., EMBO J.9:3447-3452 (1990); Benkel and Hickey, Proc. Natl. Acad. Sci.84:1337-1339 (1987) Typically, using techniques known in the art, a desired polynucleotide sequence is inserted into an expression cassette comprising genetic regulatory elements designed for operation in plants. The expression cassette is inserted into a desired expression vector with companion sequences upstream and downstream from the expression cassette suitable for expression in a plant host. The companion sequences will be of plasmid or viral origin and provide necessary characteristics to the vector to permit the vectors to move DNA from an original cloning host, such as bacteria, to the desired plant host. The basic bacterial/plant vector construct will preferably provide a broad host range prokaryote replication origin; a prokaryote selectable marker; and, for Agrobacterium transformations, T DNA sequences for Agrobacterium-mediated transfer to plant chromosomes. Where the heterologous gene is not readily amenable to detection, the construct will preferably also have a selectable marker gene suitable for determining if a plant cell has been transformed. A general review of suitable markers, for example for the members of the grass family, is found in Wilmink and Dons, 1992, Plant Mol. Biol. Reptr, 11(2):165-185. Sequences suitable for permitting integration of the heterologous sequence into the plant genome are also recommended. These might include transposon sequences and the like for homologous recombination as well as Ti sequences which permit random insertion of a heterologous expression cassette into a plant genome. Suitable prokaryote selectable markers include resistance toward antibiotics such as ampicillin or tetracycline. Other DNA sequences encoding additional functions may also be present in the vector, as is known in the art. The nucleic acid molecules of the subject invention may be included into an expression cassette for expression of the protein(s) of interest. Usually, there will be only one expression cassette, although two or more are feasible. The recombinant expression cassette will contain in addition to the heterologous protein encoding sequence the following elements, a promoter region, plant 5' untranslated sequences, initiation codon depending upon whether or not the structural gene comes equipped with one, and a transcription and translation termination sequence. Unique restriction enzyme sites at the 5' and 3' ends of the cassette allow for easy insertion into a pre-existing vector. A heterologous coding sequence may be for any protein relating to the present invention. The sequence encoding the protein of interest will encode a signal peptide which allows processing and translocation of the protein, as appropriate, and will usually lack any sequence which might result in the binding of the desired protein of the invention to a membrane. Since, for the most part, the transcriptional initiation region will be for a gene which is expressed and translocated during germination, by employing the signal peptide which provides for translocation, one may also provide for translocation of the protein of interest. In this way, the protein(s) of interest will be translocated from the cells in which they are expressed and may be efficiently harvested. Typically secretion in seeds are across the aleurone or scutellar epithelium layer into the endosperm of the seed. While it is not required that the protein be secreted from the cells in which the protein is produced, this facilitates the isolation and purification of the recombinant protein. Since the ultimate expression of the desired gene product will be in a eucaryotic cell it is desirable to determine whether any portion of the cloned gene contains sequences which will be processed out as introns by the host's splicosome machinery. If so, site-directed mutagenesis of the "intron" region may be conducted to prevent losing a portion of the genetic message as a false intron code, Reed and Maniatis, Cell 41:95-105, 1985. The vector can be microinjected directly into plant cells by use of micropipettes to mechanically transfer the recombinant DNA. Crossway, Mol. Gen. Genet, 202:179-185, 1985. The genetic material may also be transferred into the plant cell by using polyethylene glycol, Krens, et al., Nature, 296, 72-74, 1982. Another method of introduction of nucleic acid segments is high velocity ballistic penetration by small particles with the nucleic acid either within the matrix of small beads or particles, or on the surface, Klein, et al., Nature, 327, 70-73, 1987 and Knudsen and Muller, 1991, Planta, 185:330-336 teaching particle bombardment of barley endosperm to create transgenic barley. Yet another method of introduction would be fusion of protoplasts with other entities, either minicells, cells, lysosomes or other fusible lipid-surfaced bodies, Fraley, et al., Proc. Natl. Acad. Sci. USA, 79, 1859-1863, 1982. The vector may also be introduced into the plant cells by electroporation. (Fromm et al., Proc. Natl Acad. Sci. USA 82:5824, 1985). In this technique, plant protoplasts are electroporated in the presence of plasmids containing the gene construct. Electrical impulses of high field strength reversibly permeabilize biomembranes allowing the introduction of the plasmids. Electroporated plant protoplasts reform the cell wall, divide, and form plant callus. All plants from which protoplasts can be isolated and cultured to give whole regenerated plants can be transformed by the present invention so that whole plants are recovered which contain the transferred gene. It is known that practically all plants can be regenerated from cultured cells or tissues, including but not limited to all major species of sugarcane, sugar beet, cotton, fruit and other trees, legumes and vegetables. Some suitable plants include, for example, species from the genera Fragaria, Lotus, Medicago, Onobrychis, Trifolium, Trigonella, Vigna, Citrus, Linum, Geranium, Manihot, Daucus, Arabidopsis, Brassica, Raphanus, Sinapis, Atropa, Capsicum, Datura, Hyoscyamus, Lycopersion, Nicotiana, Solanum, Petunia, Digitalis, Majorana, Cichorium, Helianthus, Lactuca, Bromus, Asparagus, Antirrhinum, Hererocallis, Nemesia, Pelargonium, Panicum, Pennisetum, Ranunculus, Senecio, Salpiglossis, Cucumis, Browaalia, Glycine, Lolium, lea, Triticum, Sorghum, and Datura. Means for regeneration vary from species to species of plants, but generally a suspension of transformed protoplasts containing copies of the heterologous gene is first provided. Callus tissue is formed and shoots may be induced from callus and subsequently rooted. Alternatively, embryo formation can be induced from the protoplast suspension. These embryos germinate as natural embryos to form plants. The culture media will generally contain various amino acids and hormones, such as auxin and cytokinins. It is also advantageous to add glutamic acid and proline to the medium, especially for such species as corn and alfalfa. Shoots and roots normally develop simultaneously. Efficient regeneration will depend on the medium, on the genotype, and on the history of the culture. If these three variables are controlled, then regeneration is fully reproducible and repeatable. In some plant cell culture systems, the desired protein of the invention may be excreted or alternatively, the protein may be extracted from the whole plant. Where the desired protein of the invention is secreted into the medium, it may be collected. Alternatively, the embryos and embryoless-half seeds or other plant tissue may be mechanically disrupted to release any secreted protein between cells and tissues. The mixture may be suspended in a buffer solution to retrieve soluble proteins. Conventional protein isolation and purification methods will be then used to purify the recombinant protein. Parameters of time, temperature pH, oxygen, and volumes will be adjusted through routine methods to optimize expression and recovery of heterologous protein. iv. Bacterial Systems Bacterial expression techniques are known in the art. A bacterial promoter is any DNA sequence capable of binding bacterial RNA polymerase and initiating the downstream (3') transcription of a coding sequence (e.g., structural gene) into mRNA. A promoter will have a transcription initiation region which is usually placed proximal to the 5' end of the coding sequence. This transcription initiation region usually includes an RNA polymerase binding site and a transcription initiation site. A bacterial promoter may also have a second domain called an operator, that may overlap an adjacent RNA polymerase binding site at which RNA synthesis begins. The operator permits negative regulated (inducible) transcription, as a gene repressor protein may bind the operator and thereby inhibit transcription of a specific gene. Constitutive expression may occur in the absence of negative regulatory elements, such as the operator. In addition, positive regulation may be achieved by a gene activator protein binding sequence, which, if present is usually proximal (5') to the RNA polymerase binding sequence. An example of a gene activator protein is the catabolite activator protein (CAP), which helps initiate transcription of the lac operon in Escherichia coli (E. coli) [Raibaud et al. (1984) Annu. Rev. Genet.78:173]. Regulated expression may therefore be either positive or negative, thereby either enhancing or reducing transcription. Sequences encoding metabolic pathway enzymes provide particularly useful promoter sequences. Examples include promoter sequences derived from sugar metabolizing enzymes, such as galactose, lactose (lac) [Chang et al. (1977) Nature 798:1056], and maltose. Additional examples include promoter sequences derived from biosynthetic enzymes such as tryptophan (trp) [Goeddel et al. (1980) Nuc. Acids Res.8:4057; Yelverton et al, (1981) Nucl. Acids Res.9:731; US patent 4,738,921; EP-A-0036776 and EP-A-0121775] . The g-laotamase (bla) promoter system [Weissmann (1981) "The cloning of interferon and other mistakes." In Interferon 3 (ed. I. Gresser)], bacteriophage lambda PL [Shimatake et al. (1981) Nature 292:128] and T5 [US patent 4,689,406] promoter systems also provide useful promoter sequences. In addition, synthetic promoters which do not occur in nature also function as bacterial promoters. For example, transcription activation sequences of one bacterial or bacteriophage promoter may be joined with the operon sequences of another bacterial or bacteriophage promoter, creating a synthetic hybrid promoter [US patent 4,551,433]. For example, the tac promoter is a hybrid trp-lac promoter comprised of both trp promoter and lac operon sequences that is regulated by the lac repressor [Amann et al. (1983) Gene 25:167; de Boer et al. (1983) Proc. Natl. Acad. Sci.80:21], Furthermore, a bacterial promoter can include naturally occurring promoters of non-bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription. A naturally occurring promoter of non-bacterial origin can also be coupled with a compatible RNA polymerase to produce high levels of expression of some genes in prokaryotes. The bacteriophage T7 RNA polymerase/promoter system is an example of a coupled promoter system [Studier et al. (1986) J. Mol. Biol. /89:113; Tabor et al. (1985) Proc Natl. Acad. Sci.82:1074], In addition, a hybrid promoter can also be comprised of a bacteriophage promoter and an E. coli operator region (EPO-A-0267 851). In addition to a functioning promoter sequence, an efficient ribosome binding site is also useful for the expression of foreign genes in prokaryotes. In E. coli, the ribosome binding site is called the Shine-Dalgarno (SD) sequence and includes an initiation codon (ATG) and a sequence 3-9 nucleotides in length located 3-11 nucleotides upstream of the initiation codon [Shine et al. (1975) Nature 254:34], The SD sequence is thought to promote binding of mRNA to the ribosome by the pairing of bases between the SD sequence and the 3' and of E. coli 16S rRNA [Steitz et al. (1979) "Genetic signals and nucleotide sequences in messenger RNA." In Biological Regulation and Development: Gene Expression (ed. R.F. Goldberger)]. To express eukaryotic genes and prokaryotic genes with weak ribosome-binding site [Sambrook et al. (1989) "Expression of cloned genes in Escherichia coli." In Molecular Cloning: A Laboratory Manual], A DNA molecule may be expressed intracellularly. A promoter sequence may be directly linked with the DNA molecule, in which case the first amino acid at the N-terminus will always be a methionine, which is encoded by the ATG start codon. If desired, methionine at the N-terminus may be cleaved from the protein by in vitro incubation with cyanogen bromide or by either in vivo on in vitro incubation with a bacterial methionine N-terminal peptidase (EPO-A-0219237). Fusion proteins provide an alternative to direct expression. Usually, a DNA sequence encoding the N-terminal portion of an endogenous bacterial protein, or other stable protein, is fused to the 5' end of heterologous coding sequences. Upon expression, this construct will provide a fusion of the two amino acid sequences. For example, the bacteriophage lambda cell gene can be linked at the 5' terminus of a foreign gene and expressed in bacteria. The resulting fusion protein preferably retains a site for a processing enzyme (factor Xa) to cleave the bacteriophage protein from the foreign gene [Nagai et al. (1984) Nature 309:810]. Fusion proteins can also be made with sequences from the lacL [Jia et al. (1987) Gene 60:197], trpE [Allen et al. (1987) J. Biotechnol.5:93; Makoff et al. (1989) J. Gen. Microbiol.735:11], and Chey [EP-A-0324647] genes. The DNA sequence at the junction of the two amino acid sequences may or may not encode a cleavable site. Another example is a ubiquitin fusion protein. Such a fusion protein is made with the ubiquitin region that preferably retains a site for a processing enzyme (e.g., ubiquitin specific processing-protease) to cleave the ubiquitin from the foreign protein. Through this method, native foreign protein can be isolated [Miller et al. (1989) Bio /Technology 7:698]. Alternatively, foreign proteins can also be secreted from the cell by creating chimeric DNA molecules that encode a fusion protein comprised of a signal peptide sequence fragment that provides for secretion of the foreign protein in bacteria [US patent 4,336,336]. The signal sequence fragment usually encodes a signal peptide comprised of hydrophobic amino acids which direct the secretion of the protein from the cell. The protein is either secreted into the growth media (gram-positive bacteria) or into the periplasmic space, located between the inner and outer membrane of the cell (gram -negative bacteria). Preferably there are processing sites, which can be cleaved either in vivo or in vitro encoded between the signal peptide fragment and the foreign gene. DNA encoding suitable signal sequences can be derived from genes for secreted bacterial proteins, such as the E. coli outer membrane protein gene {ompA) [Masui et al. (1983), in: Experimental Manipulation of Gene Expression; Ghrayeb et al. (1984) EMBO J.3:2437] and the E. coli alkaline phosphatase signal sequence (phoA) [Oka et al. (1985) Proc. Natl. Acad. Sci.82:7212]. As an additional example, the signal sequence of the alpha-am lase gene from various Bacillus strains can be used to secrete heterologous proteins from B. subtilis [Palva et al. (1982) Proc. Natl. Acad. Sci. USA 79:5582; EP-A-0244042]. Usually, transcription termination sequences recognized by bacteria are regulatory regions located 3' to the translation stop codon, and thus together with the promoter flank the coding sequence. These sequences direct the transcription of an mRNA which can be translated into the polypeptide encoded by the DNA. Transcription termination sequences frequently include DNA sequences of about 50 nucleotides capable of forming stem loop structures that aid in terminating transcription. Examples include transcription termination sequences derived from genes with strong promoters, such as the trp gene in E. coli as well as other biosynthetic genes. Usually, the above described components, comprising a promoter, signal sequence (if desired), coding sequence of interest, and transcription termination sequence, are put together into expression constructs. Expression constructs are often maintained in a replicon, such as an extrachromosomal element (e.g., plasmids) capable of stable maintenance in a host, such as bacteria. The replicon will have a replication system, thus allowing it to be maintained in a prokaryotic host either for expression or for cloning and amplification. In addition, a replicon may be either a high or low copy number plasmid. A high copy number plasmid will generally have a copy number ranging from about 5 to about 200, and usually about 10 to about 150. A host containing a high copy number plasmid will preferably contain at least about 10, and more preferably at least about 20 plasmids. Either a high or low copy number vector may be selected, depending upon the effect of the vector and the foreign protein on the host. Alternatively, the expression constructs can be integrated into the bacterial genome with an integrating vector. Integrating vectors usually contain at least one sequence homologous to the bacterial chromosome that allows the vector to integrate. Integrations appear to result from recombinations between homologous DNA in the vector and the bacterial chromosome. For example, integrating vectors constructed with DNA from various Bacillus strains integrate into the Bacillus chromosome (EP-A- 0 127328). Integrating vectors may also be comprised of bacteriophage or transposon sequences. Usually, extrachromosomal and integrating expression constructs may contain selectable markers to allow for the selection of bacterial strains that have been transformed. Selectable markers can be expressed in the bacterial host and may include genes which render bacteria resistant to drugs such as ampicillin, chloramphenicol, erythromycin, kanamycin (neomycin), and tetracycline [Davies et al. (1978) Annu. Rev. Microbiol.32:469]. Selectable markers may also include biosynthetic genes, such as those in the histidine, tryptophan, and leucine biosynthetic pathways. Alternatively, some of the above described components can be put together in transformation vectors. Transformation vectors are usually comprised of a selectable market that is either maintained in a replicon or developed into an integrating vector, as described above. Expression and transformation vectors, either extra-chromosomal replicons or integrating vectors, have been developed for transformation into many bacteria. For example, expression vectors have been developed for, inter alia, the following bacteria: Bacillus subtilis [Palva et al. (1982) Proc. Natl. Acad. Sci. USA 79:5582; EP-A-0036259 and EP-A-0063953; WO 84/04541], Escherichia coli [Shimatake et al. (1981) Nature 292:128; Amann et al. (1985) Gene 40:183; Studier et al. (1986) J. Mol. Biol.789:113; EP-A-0036776,EP- A-0136829 and EP-A-0136907], Streptococcus cremoris [Powell et al. (1988) Appl. Environ. Microbiol. 54:655]; Streptococcus lividans [Powell et al. (1988) Appl. Environ. Microbiol. 54:655], Streptomyces lividans [US patent 4,745,056]. Methods of introducing exogenous DNA into bacterial hosts are well-known in the art, and usually include either the transformation of bacteria treated with CaC or other agents, such as divalent cations and DMSO. DNA can also be introduced into bacterial cells by electroporation. Transformation procedures usually vary with the bacterial species to be transformed. See e.g., [Masson et al. (1989) FEMS Microbiol. Lett.60:273; Palva et al. (1982) Proc. Natl. Acad. Sci. USA 79:5582; EP-A-0036259 and EP-A-0063953; WO 84/04541, Bacillus], [Miller et al. (1988) Proc. Natl. Acad. Sci.85:856; Wang et al. (1990) J. Bacteriol. 772:949, Campylobacter], [Cohen etal. (1973) Proc. Natl. Acad. Sci.69:2110; Dower et al. (1988) Nucleic Acids Res. 76:6127; Kushner (1978) "An improved method for transformation of Escherichia coli with ColE 1 -derived plasmids. In Genetic Engineering: Proceedings of the International Symposium on Genetic Engineering (eds. H.W. Boyer and S. Nicosia); Mandel et al. (1970) J. Mol. Biol.53:159; Taketo (1988) Biochim. Biophys. Ada 949:318; Escherichia], [Chassy et al. (1987) FEMS Microbiol. Lett.44:173 Lactobacillus]; [Fiedler et al. (1988) Anal. Biochem 770:38, Pseudomonas]; [Augustin et al. (1990) FEMS Microbiol. Lett. 66:203, Staphylococcus], [Barany et al. (1980) J. Bacteriol. 744:698; Hariander (1987) "Transformation of Streptococcus lactis by electroporation, in: Streptococcal Genetics (ed. J. Ferretti and R. Curtiss III); Perry et al. (1981) Infect. Immun.32:1295; Powell et al. (1988) Appl. Environ. Microbiol.54:655; Somkuti et al. (1987) Proc.4th Evr. Cong. Biotechnology 7:412, Streptococcus], v. Yeast Expression Yeast expression systems are also known to one of ordinary skill in the art. A yeast promoter is any DNA sequence capable of binding yeast RNA polymerase and initiating the downstream (3') transcription of a coding sequence (e.g., structural gene) into mRNA. A promoter will have a transcription initiation region which is usually placed proximal to the 5' end of the coding sequence. This transcription initiation region usually includes an RNA polymerase binding site (the "TATA Box") and a transcription initiation site. A yeast promoter may also have a second domain called an upstream activator sequence (UAS), which, if present, is usually distal to the structural gene. The UAS permits regulated (inducible) expression. Constitutive expression occurs in the absence of a UAS. Regulated expression may be either positive or negative, thereby either enhancing or reducing transcription. Yeast is a fermenting organism with an active metabolic pathway, therefore sequences encoding enzymes in the metabolic pathway provide particularly useful promoter sequences. Examples include alcohol dehydrogenase (ADH) (EP-A-0 284 044), enolase, glucokinase, glucose-6-phosphate isomerase, glyceraldehyde-3-phosphate-dehydrogenase (GAP or GAPDH), hexokinase, phosphofructokinase, 3- phosphoglycerate mutase, and pyruvate kinase (PyK) (EPO-A-0329203). The yeast PH05 gene, encoding acid phosphatase, also provides useful promoter sequences [Myanohara et al. (1983) Proc. Natl. Acad. Sci. USA80:\]. In addition, synthetic promoters which do not occur in nature also function as yeast promoters. For example, UAS sequences of one yeast promoter may be joined with the transcription activation region of another yeast promoter, creating a synthetic hybrid promoter. Examples of such hybrid promoters include the ADH regulatory sequence linked to the GAP transcription activation region (US Patent Nos. 4,876,197 and 4,880,734). Other examples of hybrid promoters include promoters which consist of the regulatory sequences of either the ADH2, GAL4, GAL10, OR PH05 genes, combined with the transcriptional activation region of a gly colytic enzyme gene such as GAP or PyK (EP-A-0164556). Furthermore, a yeast promoter can include naturally occurring promoters of non-yeast origin that have the ability to bind yeast RNA polymerase and initiate transcription. Examples of such promoters include, inter alia, [Cohen et al. (1980) Proc. Natl. Acad. Sci. USA 77:1078; Henikoff et al. (1981) Nature 283:835; Hollenberg et al. (1981) Curr. Topics Microbiol. Immunol.96:119; Hollenberg et al. (1979) "The Expression of Bacterial Antibiotic Resistance Genes in the Yeast Saccharomyces cerevisiae," in: Plasmids of Medical, Environmental and Commercial Importance (eds. K.N. Timmis and A. Puhler); Mercerau-Puigalon et al. (1980) Gene 77:163; Panthier et al. (1980) Curr. Genet.2:109;]. A DNA molecule may be expressed intracellularly in yeast. A promoter sequence may be directly linked with the DNA molecule, in which case the first amino acid at the N-terminus of the recombinant protein will always be a methionine, which is encoded by the ATG start codon. If desired, methionine at the N-terminus may be cleaved from the protein by in vitro incubation with cyanogen bromide. Fusion proteins provide an alternative for yeast expression systems, as well as in mammalian, baculovirus, and bacterial expression systems. Usually, a DNA sequence encoding the N-terminal portion of an endogenous yeast protein, or other stable protein, is fused to the 5' end of heterologous coding sequences. Upon expression, this construct will provide a fusion of the two amino acid sequences. For example, the yeast or human superoxide dismutase (SOD) gene, can be linked at the 5' terminus of a foreign gene and expressed in yeast. The DNA sequence at the junction of the two amino acid sequences may or may not encode a cleavable site. See e.g., EP-A-0196056. Another example is a ubiquitin fusion protein. Such a fusion protein is made with the ubiquitin region that preferably retains a site for a processing enzyme (e.g., ubiquitin- specific processing protease) to cleave the ubiquitin from the foreign protein. Through this method, therefore, native foreign protein can be isolated {e.g., WO88/024066). Alternatively, foreign proteins can also be secreted from the cell into the growth media by creating chimeric DNA molecules that encode a fusion protein comprised of a leader sequence fragment that provide for secretion in yeast of the foreign protein. Preferably, there are processing sites encoded between the leader fragment and the foreign gene that can be cleaved either in vivo or in vitro. The leader sequence fragment usually encodes a signal peptide comprised of hydrophobic amino acids which direct the secretion of the protein from the cell. DNA encoding suitable signal sequences can be derived from genes for secreted yeast proteins, such as the yeast invertase gene (EP-A-0 012 873; JPO.62,096,086) and the A-factor gene (US patent 4,588,684). Alternatively, leaders of non-yeast origin, such as an interferon leader, exist that also provide for secretion in yeast (EP-A-0060057). A preferred class of secretion leaders are those that employ a fragment of the yeast alpha-factor gene, which contains both a "pre" signal sequence, and a "pro" region. The types of alpha-factor fragments that can be employed include the full-length pre-pro alpha factor leader (about 83 amino acid residues) as well as truncated alpha-factor leaders (usually about 25 to about 50 amino acid residues) (US Patents 4,546,083 and 4,870,008; EP-A-0324274). Additional leaders employing an alpha-factor leader fragment that provides for secretion include hybrid alpha-factor leaders made with a presequence of a first yeast, but a pro-region from a second yeast alphafactor. (e.g., see WO 89/02463.) Usually, transcription termination sequences recognized by yeast are regulatory regions located 3' to the translation stop codon, and thus together with the promoter flank the coding sequence. These sequences direct the transcription of an mRNA which can be translated into the polypeptide encoded by the DNA. Examples of transcription terminator sequence and other yeast-recognized termination sequences, such as those coding for glycolytic enzymes. Usually, the above described components, comprising a promoter, leader (if desired), coding sequence of interest, and transcription termination sequence, are put together into expression constructs. Expression constructs are often maintained in a replicon, such as an extrachromosomal element (e.g., plasmids) capable of stable maintenance in a host, such as yeast or bacteria. The replicon may have two replication systems, thus allowing it to be maintained, for example, in yeast for expression and in a prokaryotic host for cloning and amplification. Examples of such yeast-bacteria shuttle vectors include YEp24 [Botstein et al. (1979) Gene 8:17-24], pCl/1 [Brake et al, (1984) PNAS USA 87:4642-4646], and YRpl7 [Stinchcomb et al. (1982) J. Mol. Biol.758:157]. In addition, a replicon may be either a high or low copy number plasmid. A high copy number plasmid will generally have a copy number ranging from about 5 to about 200, and usually about 10 to about 150. A host containing a high copy number plasmid will preferably have at least about 10, and more preferably at least about 20. Enter a high or low copy number vector may be selected, depending upon the effect of the vector and the foreign protein on the host. See e.g., Brake et al., supra. Alternatively, the expression constructs can be integrated into the yeast genome with an integrating vector. Integrating vectors usually contain at least one sequence homologous to a yeast chromosome that allows the vector to integrate, and preferably contain two homologous sequences flanking the expression construct. Integrations appear to result from recombinations between homologous DNA in the vector and the yeast chromosome [Orr-Weaver et al. (1983) Methods in Enzymol.707:228-245]. An integrating vector may be directed to a specific locus in yeast by selecting the appropriate homologous sequence for inclusion in the vector. See Orr-Weaver et al., supra. One or more expression construct may integrate, possibly affecting levels of recombinant protein produced [Rine et al. (1983) Proc. Natl. Acad. Sci. USA 80:6750]. The chromosomal sequences included in the vector can occur either as a single segment in the vector, which results in the integration of the entire vector, or two segments homologous to adjacent segments in the chromosome and flanking the expression construct in the vector, which can result in the stable integration of only the expression construct. Usually, extrachromosomal and integrating expression constructs may contain selectable markers to allow for the selection of yeast strains that have been transformed. Selectable markers may include biosynthetic genes that can be expressed in the yeast host, such as ADE2, 7/754, LEU2, TRPI, and ALG1 , and the G418 resistance gene, which confer resistance in yeast cells to tunicamycin and G418, respectively. In addition, a suitable selectable marker may also provide yeast with the ability to grow in the presence of toxic compounds, such as metal. For example, the presence of CUPI allows yeast to grow in the presence of copper ions [Butt etal. (1987) Microbiol, Rev.57:351], Alternatively, some of the above described components can be put together into transformation vectors. Transformation vectors are usually comprised of a selectable marker that is either maintained in a replicon or developed into an integrating vector, as described above. Expression and transformation vectors, either extrachromosomal replicons or integrating vectors, have been developed for transformation into many yeasts. For example, expression vectors have been developed for, inter alia, the following yeasts:Candida albicans [Kurtz, et al. (1986) Mol. Cell. Biol.6:142], Candida maltosa [Kunze, et al. (1985) J. Basic Microbiol.25:141]. Hansenula polymorpha [Gleeson, et al. (1986) J. Gen. Microbiol.732:3459; Roggenkamp et al. (1986) Mol. Gen. Genet.202:302], Kluyveromyces fragilis [Das, et al. (1984) J. Bacteriol.758:1165], Kluyveromyces lactis [De Louvencourt et al. (1983) J. Bacteriol.754:737; Van den Berg et al. (1990) Bio/Technology 8:135], Pichia guillerimondii [Kunze et al. (1985) J. Basic Microbiol.25:141], Pichia pastoris [Cregg, et al. (1985) Mol. Cell. Biol.5:3376; US Patent Nos.4,837,148 and 4,929,555], Saccharomyces cerevisiae [Hinnen etal. (1978) Proc. Natl. Acad. Sci. USA 75:1929; Ito etal. (1983) J. Bacteriol.753:163], Schizosaccharomyces pombe [Beach and Nurse (1981) Nature 300:706], and Yarrowia lipolytica [Davidow, et al. (1985) Curr. Genet. 70:380471 Gaillardin, et al. (1985) Curr. Genet. 70:49]. Methods of introducing exogenous DNA into yeast hosts are well-known in the art, and usually include either the transformation of spheroplasts or of intact yeast cells treated with alkali cations. Transformation procedures usually vary with the yeast species to be transformed. See e.g., [Kurtz et al. (1986) Mol. Cell. Biol. 6:142; Kunze et al. (1985) J. Basic Microbiol.25:141; Candida]; [Gleeson et al. (1986) J. Gen. Microbiol. 732:3459; Roggenkamp et al. (1986) Mol. Gen. Genet.202:302; Hansenula]; [Das et al. (1984) J. Bacteriol. 758:1165; De Louvencourt et al. (1983)7. Bacteriol.754:1165; Van den Berg et al. (1990) Bio/Technology 8:135; Kluyveromyces]; [Cregg et al. (1985) Mol. Cell. Biol.5:3376; Kunze et al. (1985) 7. Basic Microbiol. 25:141; US Patent Nos.4,837,148 and 4,929,555; Pichia]; [Hinnen et al. (1978) Proc. Natl. Acad. Sci. USA 75;1929; Ito et al. (1983) 7. Bacteriol.753:163 Saccharomyces]; [Beach and Nurse (1981) Nature 300:706; Schizosaccharomyces]; [Davidow et al. (1985) Curr. Genet. 70:39; Gaillardin et al. (1985) Curr. Genet. 70:49; Yarrowia], Antibodies As used herein, the term "antibody" refers to a polypeptide or group of polypeptides composed of at least one antibody combining site. An "antibody combining site" is the three-dimensional binding space with an internal surface shape and charge distribution complementary to the features of an epitope of an antigen, which allows a binding of the antibody with the antigen. "Antibody" includes, for example, vertebrate antibodies, hybrid antibodies, chimeric antibodies, humanised antibodies, altered antibodies, univalent antibodies, Fab proteins, and single domain antibodies. Antibodies against the proteins of the invention are useful for affinity chromatography, immunoassays, and distinguishing/identifying meningococcal proteins. Antibodies to the proteins of the invention, both polyclonal and monoclonal, may be prepared by conventional methods. In general, the protein is first used to immunize a suitable animal, preferably a mouse, rat, rabbit or goat. Rabbits and goats are preferred for the preparation of polyclonal sera due to the volume of serum obtainable, and the availability of labeled anti-rabbit and anti-goat antibodies. Immunization is generally performed by mixing or emulsifying the protein in saline, preferably in an adjuvant such as Freund's complete adjuvant, and injecting the mixture or emulsion parenterally (generally subcutaneously or intramuscularly). A dose of 50-200 Dginjection is typically sufficient. Immunization is generally boosted 2-6 weeks later with one or more injections of the protein in saline, preferably using Freund's incomplete adjuvant. One may alternatively generate antibodies by in vitro immunization using methods known in the art, which for the purposes of this invention is considered equivalent to in vivo immunization. Polyclonal antisera is obtained by bleeding the immunized animal into a glass or plastic container, incubating the blood at 25 DC for one hour, followed by incubating at 4DC for 2-18 hours. The serum is recovered by centrifugation {e.g., l,000g for 10 minutes). About 20-50 ml per bleed may be obtained from rabbits. Monoclonal antibodies are prepared using the standard method of Kohler & Milstein [Nature (1975) 256:495-96], or a modification thereof. Typically, a mouse or rat is immunized as described above. However, rather than bleeding the animal to extract serum, the spleen (and optionally several large lymph nodes) is removed and dissociated into single cells. If desired, the spleen cells may be screened (after removal of nonspecifically adherent cells) by applying a cell suspension to a plate or well coated with the protein antigen. B -cells expressing membrane-bound immunoglobulin specific for the antigen bind to the plate, and are not rinsed away with the rest of the suspension. Resulting B -cells, or all dissociated spleen cells, are then induced to fuse with myeloma cells to form hybridomas, and are cultured in a selective medium (e.g., hypoxanthine, aminopterin, thymidine medium, "HAT"). The resulting hybridomas are plated by limiting dilution, and are assayed for the production of antibodies which bind specifically to the immunizing antigen (and which do not bind to unrelated antigens). The selected MAb-secreting hybridomas are then cultured either in vitro {e.g., in tissue culture bottles or hollow fiber reactors), or in vivo (as ascites in mice). If desired, the antibodies (whether polyclonal or monoclonal) may be labeled using conventional techniques. Suitable labels include fluorophores, chromophores, radioactive atoms (particularly 32 P and l25 I), electron-dense reagents, enzymes, and ligands having specific binding partners. Enzymes are typically detected by their activity. For example, horseradish peroxidase is usually detected by its ability to convert 3,3',5,5'-tetramethylbenzidine (TMB) to a blue pigment, quantifiable with a spectrophotometer. "Specific binding partner" refers to a protein capable of binding a ligand molecule with high specificity, as for example in the case of an antigen and a monoclonal antibody specific therefor. Other specific binding partners include biotin and avidin or streptavidin, IgG and protein A, and the numerous receptor-ligand couples known in the art. It should be understood that the above description is not meant to categorize the various labels into distinct classes, as the same label may serve in several different modes. For example, l25 I may serve as a radioactive label or as an electron-dense reagent. HRP may serve as enzyme or as antigen for a MAb. Further, one may combine various labels for desired effect. For example, MAbs and avidin also require labels in the practice of this invention: thus, one might label a MAb with biotin, and detect its presence with avidin labeled with l25 I, or with an anti-biotin MAb labeled with HRP. Other permutations and possibilities will be readily apparent to those of ordinary skill in the art, and are considered as equivalents within the scope of the invention. Pharmaceutical Compositions Pharmaceutical compositions can comprise either polypeptides, antibodies, or nucleic acid of the invention. The pharmaceutical compositions will comprise a therapeutically effective amount of either polypeptides, antibodies, or polynucleotides of the claimed invention. The term "therapeutically effective amount" as used herein refers to an amount of a therapeutic agent to treat, ameliorate, or prevent a desired disease or condition, or to exhibit a detectable therapeutic or preventative effect. The effect can be detected by, for example, chemical markers or antigen levels. Therapeutic effects also include reduction in physical symptoms, such as decreased body temperature. The precise effective amount for a subject will depend upon the subject's size and health, the nature and extent of the condition, and the therapeutics or combination of therapeutics selected for administration. Thus, it is not useful to specify an exact effective amount in advance. However, the effective amount for a given situation can be determined by routine experimentation and is within the judgement of the clinician. For purposes of the present invention, an effective dose will be from about 0.01 mg/ kg to 50 mg/kg or 0.05 mg/kg to about 10 mg/kg of the DNA constructs in the individual to which it is administered. A pharmaceutical composition can also contain a pharmaceutically acceptable carrier. The term "pharmaceutically acceptable carrier" refers to a carrier for administration of a therapeutic agent, such as antibodies or a polypeptide, genes, and other therapeutic agents. The term refers to any pharmaceutical carrier that does not itself induce the production of antibodies harmful to the individual receiving the composition, and which may be administered without undue toxicity. Suitable carriers may be large, slowly metabolized macromolecules such as proteins, polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers, and inactive virus particles. Such carriers are well known to those of ordinary skill in the art. Pharmaceutically acceptable salts can be used therein, for example, mineral acid salts such as hydrochlorides, hydrobromides, phosphates, sulfates, and the like; and the salts of organic acids such as acetates, propionates, malonates, benzoates, and the like. A thorough discussion of pharmaceutically acceptable excipients is available in Remington's Pharmaceutical Sciences (Mack Pub. Co., NJ.1991). Pharmaceutically acceptable carriers in therapeutic compositions may contain liquids such as water, saline, glycerol and ethanol. Additionally, auxiliary substances, such as wetting or emulsifying agents, pH buffering substances, and the like, may be present in such vehicles. Typically, the therapeutic compositions are prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared. Liposomes are included within the definition of a pharmaceutically acceptable carrier. Delivery Methods Once formulated, the compositions of the invention can be administered directly to the subject. The subjects to be treated can be animals; in particular, human subjects can be treated. Direct delivery of the compositions will generally be accomplished by injection, either subcutaneously, intraperitoneally, intravenously or intramuscularly or delivered to the interstitial space of a tissue. The compositions can also be administered into a lesion. Other modes of administration include oral and pulmonary administration, suppositories, and transdermal or transcutaneous applications (e.g., see WO98/20734), needles, and gene guns or hyposprays. Dosage treatment may be a single dose schedule or a multiple dose schedule. Vaccines Vaccines according to the invention may either be prophylactic (i.e., to prevent infection) or therapeutic (i.e., to treat disease after infection). Such vaccines comprise immunising antigen(s), immunogen(s), polypeptide(s), protein(s) or nucleic acid, usually in combination with "pharmaceutically acceptable carriers," which include any carrier that does not itself induce the production of antibodies harmful to the individual receiving the composition. Suitable carriers are typically large, slowly metabolized macromolecules such as proteins, polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers, lipid aggregates (such as oil droplets or liposomes), and inactive virus particles. Such carriers are well known to those of ordinary skill in the art. Additionally, these carriers may function as immunostimulating agents ("adjuvants"). Furthermore, the antigen or immunogen may be conjugated to a bacterial toxoid, such as a toxoid from diphtheria, tetanus, cholera, 77. pylori, etc. pathogens. Preferred adjuvants to enhance effectiveness of the composition include, but are not limited to: (1) aluminum salts (alum), such as aluminum hydroxide, aluminum phosphate, aluminum sulfate, etc; (2) oil-in-water emulsion formulations (with or without other specific immunostimulating agents such as muramyl peptides (see below) or bacterial cell wall components), such as for example (a) MF59™ (WO 90/14837; Chapter 10 in Vaccine design: the subunit and adjuvant approach, eds. Powell & Newman, Plenum Press 1995), containing 5% Squalene, 0.5% Tween 80, and 0.5% Span 85 (optionally containing various amounts of MTP-PE (see below), although not required) formulated into submicron particles using a microfluidizer such as Model HOY microfluidizer (Microfluidics, Newton, MA), (b) SAF, containing 10% Squalane, 0.4% Tween 80, 5% pluronic-blocked polymer L121, and thr-MDP (see below) either microfluidized into a submicron emulsion or vortexed to generate a larger particle size emulsion, and (c) Ribi™ adjuvant system (RAS), (Ribi Immunochem, Hamilton, MT) containing 2% Squalene, 0.2% Tween 80, and one or more bacterial cell wall components from the group consisting of monophosphorylipid A (MPL), trehalose dimycolate (TDM), and cell wall skeleton (CWS), preferably MPL + CWS (Detox™); (3) saponin adjuvants, such as Stimulon™ (Cambridge Bioscience, Worcester, MA) may be used or particles generated therefrom such as ISCOMs (immunostimulating complexes); (4) Complete Freund's Adjuvant (CFA) and Incomplete Freund's Adjuvant (IFA); (5) cytokines, such as interleukins (e.g., IL-1, IL-2, IL-4, IL-5, IL-6, IL-7, IL-12, etc.), interferons (e.g., gamma interferon), macrophage colony stimulating factor (M-CSF), tumor necrosis factor (TNF), etc; and (6) other substances that act as immunostimulating agents to enhance the effectiveness of the composition. Alum and MF59™ are preferred. As mentioned above, muramyl peptides include, but are not limited to, N-acetyl-muramyl-L-threonyl-D- isoglutamine (thr-MDP), N-acetyl-normuramyl- -alanyl-D-isoglutamine (nor-MDP), N-acetylmuramyl-L- alanyl-D-isoglutaminyl-L-alanine-2-(l'-2'-dipalmitoyl-^n-glycero-3-hydroxyphosphoryloxy)-ethylamine The immunogenic compositions (e.g., the immunising antigen/immunogen/polypeptide/protein/ nucleic acid, pharmaceutically acceptable carrier, and adjuvant) typically will contain diluents, such as water, saline, glycerol, ethanol, etc. Additionally, auxiliary substances, such as wetting or emulsifying agents, pH buffering substances, and the like, may be present in such vehicles. Typically, the immunogenic compositions are prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection may also be prepared. The preparation also may be emulsified or encapsulated in liposomes for enhanced adjuvant effect, as discussed above under pharmaceutically acceptable carriers. Immunogenic compositions used as vaccines comprise an immunologically effective amount of the antigenic or immunogenic polypeptides, as well as any other of the above-mentioned components, as needed. By "immunologically effective amount", it is meant that the administration of that amount to an individual, either in a single dose or as part of a series, is effective for treatment or prevention. This amount varies depending upon the health and physical condition of the individual to be treated, the taxonomic group of individual to be treated (e.g., nonhuman primate, primate, etc.), the capacity of the individual's immune system to synthesize antibodies, the degree of protection desired, the formulation of the vaccine, the treating doctor's assessment of the medical situation, and other relevant factors. It is expected that the amount will fall in a relatively broad range that can be determined through routine trials. The immunogenic compositions are conventionally administered parenterally, e.g., by injection, either subcu- taneously, intramuscularly, or transdermally/transcutaneously (e.g., WO98/20734). Additional formulations suitable for other modes of administration include oral and pulmonary formulations, suppositories, and transdermal applications. Dosage treatment may be a single dose schedule or a multiple dose schedule. The vaccine may be administered in conjunction with other immunoregulatory agents. As an alternative to protein-based vaccines, DNA vaccination may be employed [e.g., Robinson & Torres (1997) Seminars in Immunology 9:271-283; Donnelly et al. (1997) Annu Rev Immunol 15:617-648; see later herein]. Gene Delivery Vehicles Gene therapy vehicles for delivery of constructs including a coding sequence of a therapeutic of the invention, to be delivered to the mammal for expression in the mammal, can be administered either locally or systemically. These constructs can utilize viral or non-viral vector approaches in in vivo or ex vivo modality. Expression of such coding sequence can be induced using endogenous mammalian or heterologous promoters. Expression of the coding sequence in vivo can be either constitutive or regulated. The invention includes gene delivery vehicles capable of expressing the contemplated nucleic acid sequences. The gene delivery vehicle is preferably a viral vector and, more preferably, a retroviral, adenoviral, adeno-associated viral (AAV), herpes viral, or alphavirus vector. The viral vector can also be an astrovirus, coronavirus, orthomyxovirus, papovavirus, paramyxovirus, parvovirus, picornavirus, poxvirus, or togavirus viral vector. See generally, Jolly (1994) Cancer Gene Therapy 1:51-64; Kimura (1994) Human Gene Therapy 5:845-852; Connelly (1995) Human Gene Therapy 6:185-193; and Kaplitt (1994) Nature Genetics 6:148-153. Retroviral vectors are well known in the art and we contemplate that any retroviral gene therapy vector is employable in the invention, including B, C and D type retroviruses, xenotropic retroviruses (for example, NZB-X1, NZB-X2 and NZB9-1 (see O'Neill (1985) 7. Virol.53:160) polytropic retroviruses e.g., MCF and MCF-MLV (see Kelly (1983) 7. Virol.45:291), spumaviruses and lentiviruses. See RNA Tumor Viruses, Second Edition, Cold Spring Harbor Laboratory, 1985. Portions of the retroviral gene therapy vector may be derived from different retroviruses. For example, retrovector LTRs may be derived from a Murine Sarcoma Virus, a tRNA binding site from a Rous Sarcoma Virus, a packaging signal from a Murine Leukemia Virus, and an origin of second strand synthesis from an Avian Leukosis Virus. These recombinant retroviral vectors may be used to generate transduction competent retroviral vector particles by introducing them into appropriate packaging cell lines (see US patent 5,591,624). Retrovirus vectors can be constructed for site-specific integration into host cell DNA by incorporation of a chimeric integrase enzyme into the retroviral particle (see W 096/37626). It is preferable that the recombinant viral vector is a replication defective recombinant virus. Packaging cell lines suitable for use with the above-described retrovirus vectors are well known in the art, are readily prepared (see WO95/30763 and WO92/05266), and can be used to create producer cell lines (also termed vector cell lines or "VCLs") for the production of recombinant vector particles. Preferably, the packaging cell lines are made from human parent cells (e.g., HT1080 cells) or mink parent cell lines, which eliminates inactivation in human serum. Preferred retroviruses for the construction of retroviral gene therapy vectors include Avian Leukosis Virus, Bovine Leukemia, Virus, Murine Leukemia Virus, Mink-Cell Focus-Inducing Virus, Murine Sarcoma Virus, Reticuloendotheliosis Virus and Rous Sarcoma Virus. Particularly preferred Murine Leukemia Viruses include 4070A and 1504A (Hartley and Rowe (1976) 7 Virol 19:19-25), Abelson (ATCC No. VR-999), Friend (ATCC No. VR-245), Graffi, Gross (ATCC Nol VR-590), Kirsten, Harvey Sarcoma Virus and Rauscher (ATCC No. VR-998) and Moloney Murine Leukemia Virus (ATCC No. VR-190). Such retroviruses may be obtained from depositories or collections such as the American Type Culture Collection ("ATCC") in Rockville, Maryland or isolated from known sources using commonly available techniques. Exemplary known retroviral gene therapy vectors employable in this invention include those described in patent applications GB2200651, EP0415731, EP0345242, EP0334301, WO89/02468; WO89/05349, WO89/09271, WO90/02806, WO90/07936, WO94/03622, W093/25698, W093/25234, WO93/11230, WO93/10218, WO91/02805, WO91/02825, WO95/07994, US 5,219,740, US 4,405,712, US 4,861,719, US 4,980,289, US 4,777,127, US 5,591,624. See also Vile (1993) Cancer Res 53:3860-3864; Vile (1993) Cancer Res 53:962-967; Ram (1993) Cancer Res 53 (1993) 83-88; Takamiya (1992) 7 Neurosci Res 33:493-503; Baba (1993) 7 Neurosurg 79:729-735; Mann (1983) Cell 33:153; Cane (1984) Proc Natl Acad Sci 81:6349; and Miller (1990) Human Gene Therapy 1. Human adenoviral gene therapy vectors are also known in the art and employable in this invention. See, for example, Berkner (1988) Biotechniques 6:616 and Rosenfeld (1991) Science 252:431, and WO93/07283, WO93/06223, and WO93/07282. Exemplary known adenoviral gene therapy vectors employable in this invention include those described in the above referenced documents and in W094/12649, WO93/03769, W093/19191, W094/28938, WO95/11984, WO95/00655, WO95/27071, W095/29993, W095/34671, WO96/05320, WO94/08026, WO94/11506, WO93/06223, W094/24299, WO95/14102, W095/24297, WO95/02697, W094/28152, W094/24299, WO95/09241, WO95/25807, WO95/05835, W094/18922 and WO95/09654. Alternatively, administration of DNA linked to killed adenovirus as described in Curiel (1992) Hum. Gene Ther.3:147-154 may be employed. The gene delivery vehicles of the invention also include adenovirus associated virus (AAV) vectors. Leading and preferred examples of such vectors for use in this invention are the AAV-2 based vectors disclosed in Srivastava, WO93/09239. Most preferred AAV vectors comprise the two AAV inverted terminal repeats in which the native D-sequences are modified by substitution of nucleotides, such that at least 5 native nucleotides and up to 18 native nucleotides, preferably at least 10 native nucleotides up to 18 native nucleotides, most preferably 10 native nucleotides are retained and the remaining nucleotides of the D-sequence are deleted or replaced with non-native nucleotides. The native D-sequences of the AAV inverted terminal repeats are sequences of 20 consecutive nucleotides in each AAV inverted terminal repeat (i.e., there is one sequence at each end) which are not involved in HP formation. The non-native replacement nucleotide may be any nucleotide other than the nucleotide found in the native D-sequence in the same position. Other employable exemplary AAV vectors are pWP-19, pWN-1 , both of which are disclosed in Nahreini (1993) Gene 124:257-262. Another example of such an AAV vector is psub201 (see Samulski (1987) ]. Virol.61:3096). Another exemplary AAV vector is the Double-D ITR vector. Construction of the Double-D ITR vector is disclosed in US Patent 5,478,745. Still other vectors are those disclosed in Carter US Patent 4,797,368 and Muzyczka US Patent 5,139,941, Chartejee US Patent 5,474,935, and Kotin W 094/288157. Yet a further example of an AAV vector employable in this invention is SSV9AFABTKneo, which contains the AFP enhancer and albumin promoter and directs expression predominantly in the liver. Its structure and construction are disclosed in Su (1996) Human Gene Therapy 7:463-470. Additional AAV gene therapy vectors are described in US 5,354,678, US 5,173,414, US 5,139,941, and US 5,252,479. The gene therapy vectors of the invention also include herpes vectors. Leading and preferred examples are herpes simplex virus vectors containing a sequence encoding a thymidine kinase polypeptide such as those disclosed in US 5,288,641 and EP0176170 (Roizman). Additional exemplary herpes simplex virus vectors include HFEM/ICP6-LacZ disclosed in WO95/04139 (Wistar Institute), pHSVIac described in Geller (1988) Science 241:1667-1669 and in WO90/09441 and WO92/07945, HSV Us3::pgC-lacZ described in Fink (1992) Human Gene Therapy 3:11-19 and HSV 7134, 2 RH 105 and GAL4 described in EP 0453242 (Breakefield), and those deposited with the ATCC as accession numbers ATCC VR-977 and ATCC VR-260. Also contemplated are alpha virus gene therapy vectors that can be employed in this invention. Preferred alpha virus vectors are Sindbis viruses vectors. Togaviruses, Semliki Forest virus (ATCC VR-67; ATCC VR-1247), Middleberg virus (ATCC VR-370), Ross River virus (ATCC VR-373; ATCC VR-1246), Venezuelan equine encephalitis virus (ATCC VR923; ATCC VR-1250; ATCC VR-1249; ATCC VR-532), and those described in US patents 5,091,309, 5,217,879, and WO92/10578. More particularly, those alpha virus vectors described in US Serial No.08/405,627, filed March 15, 1995 ,W O94/21792, WO92/10578, WO95/07994, US 5,091,309 and US 5,217,879 are employable. Such alpha viruses may be obtained from depositories or collections such as the ATCC in Rockville, Maryland or isolated from known sources using commonly available techniques. Preferably, alphavirus vectors with reduced cytotoxicity are used (see USSN 08/679640). DNA vector systems such as eukaryotic layered expression systems are also useful for expressing the nucleic acids of the invention. See WO95/07994 for a detailed description of eukaryotic layered expression systems. Preferably, the eukaryotic layered expression systems of the invention are derived from alphavirus vectors and most preferably from Sindbis viral vectors. Other viral vectors suitable for use in the present invention include those derived from poliovirus, for example ATCC VR-58 and those described in Evans, Nature 339 (1989) 385 and Sabin (1973) 7. Biol. Standardization 1:115; rhinovirus, for example ATCC VR-1110 and those described in Arnold (1990) 7 Cell Biochem L401; pox viruses such as canary pox virus or vaccinia virus, for example ATCC VR-111 and ATCC VR-2010 and those described in Fisher-Hoch (1989) Proc Natl Acad Sci 86:317; Flexner (1989) Ann NY Acad Sci 569:86, Flexner (1990) Vaccine 8:17; in US 4,603,112 and US 4,769,330 and WO89/01973; SV40 virus, for example ATCC VR-305 and those described in Mulligan (1979) Nature 277:108 and Madzak (1992) 7 Gen Virol 73:1533; influenza virus, for example ATCC VR-797 and recombinant influenza viruses made employing reverse genetics techniques as described in US 5,166,057 and in Enami (1990) Proc Natl Acad Sci 87:3802-3805; Enami & Palese (1991) 7 Virol 65:2711-2713 and Luytjes (1989) Cell 59:110, (see also McMichael (1983) NEJ Med 309:13, and Yap (1978) Nature 273:238 and Nature (1979) 277:108); human immunodeficiency virus as described in EP-0386882 and in Buchschacher (1992) 7. Virol.66:2731; measles virus, for example ATCC VR-67 and VR-1247 and those described in EP-0440219; Aura virus, for example ATCC VR-368; Bebaru virus, for example ATCC VR-600 and ATCC VR-1240; Cabassou virus, for example ATCC VR-922; Chikungunya virus, for example ATCC VR-64 and ATCC VR-1241; Fort Morgan Virus, for example ATCC VR-924; Getah virus, for example ATCC VR-369 and ATCC VR-1243; Kyzylagach virus, for example ATCC VR-927; Mayaro virus, for example ATCC VR-66; Mucambo virus, for example ATCC VR-580 and ATCC VR-1244; Ndumu virus, for example ATCC VR-371; Pixuna virus, for example ATCC VR-372 and ATCC VR-1245; Tonate virus, for example ATCC VR-925; Triniti virus, for example ATCC VR-469; Una virus, for example ATCC VR-374; Whataroa virus, for example ATCC VR-926; Y-62-33 virus, for example ATCC VR-375; O'Nyong virus, Eastern encephalitis virus, for example ATCC VR-65 and ATCC VR-1242; Western encephalitis virus, for example ATCC VR-70, ATCC VR-1251, ATCC VR-622 and ATCC VR-1252; and coronavirus, for example ATCC VR-740 and those described in Hamre (1966) Proc Soc Exp Biol Med 121:190. Delivery of the compositions of this invention into cells is not limited to the above mentioned viral vectors. Other delivery methods and media may be employed such as, for example, nucleic acid expression vectors, polycationic condensed DNA linked or unlinked to killed adenovirus alone, for example see US Serial No. 08/366,787, filed December 30, 1994 and Curiel (1992) Hum Gene Ther 3:147-154 ligand linked DNA, for example see Wu (1989) J Biol Chem 264:16985-16987, eucaryotic cell delivery vehicles cells, for example see US Serial No.08/240,030, filed May 9, 1994, and US Serial No. 08/404,796, deposition of photopolymerized hydrogel materials, hand-held gene transfer particle gun, as described in US Patent 5,149,655, ionizing radiation as described in US5,206,152 and in W092/11033, nucleic charge neutralization or fusion with cell membranes. Additional approaches are described in Philip (1994) Mol Cell Biol 14:2411-2418 and in Woffendin (1994) Proc Nαt/Λcα 5c 91 : 1581 -1585. Particle mediated gene transfer may be employed, for example see US Serial No.60/023,867. Briefly, the sequence can be inserted into conventional vectors that contain conventional control sequences for high level expression, and then incubated with synthetic gene transfer molecules such as polymeric DNA-binding cations like polylysine, protamine, and albumin, linked to cell targeting ligands such as asialoorosomucoid, as described in Wu & Wu (1987) 7. Biol. Chem.262:4429-4432, insulin as described in Hucked (1990) Biochem Pharmacol 40:253-263, galactose as described in Plank (1992) Bioconjugate Chem 3:533-539, lactose or transferrin. Naked DNA may also be employed. Exemplary naked DNA introduction methods are described in WO 90/11092 and US 5,580,859. Uptake efficiency may be improved using biodegradable latex beads. DNA coated latex beads are efficiently transported into cells after endocytosis initiation by the beads. The method may be improved further by treatment of the beads to increase hydrophobicity and thereby facilitate disruption of the endosome and release of the DNA into the cytoplasm. Liposomes that can act as gene delivery vehicles are described in US 5,422,120, W095/13796, W094/23697, W091/14445 and EP-524,968. As described in USSN.60/023,867, on non-viral delivery, the nucleic acid sequences encoding a polypeptide can be inserted into conventional vectors that contain conventional control sequences for high level expression, and then be incubated with synthetic gene transfer molecules such as polymeric DNA-binding cations like polylysine, protamine, and albumin, linked to cell targeting ligands such as asialoorosomucoid, insulin, galactose, lactose, or transferrin. Other delivery systems include the use of liposomes to encapsulate DNA comprising the gene under the control of a variety of tissue-specific or ubiquitously-active promoters. Further non-viral delivery suitable for use includes mechanical delivery systems such as the approach described in Woffendin et al (1994) Proc. Natl. Acad. Sci. USA 91 (24): 11581-11585. Moreover, the coding sequence and the product of expression of such can be delivered through deposition of photopolymerized hydrogel materials. Other conventional methods for gene delivery that can be used for delivery of the coding sequence include, for example, use of hand-held gene transfer particle gun, as described in US 5,149,655; use of ionizing radiation for activating transferred gene, as described in US 5,206,152 and WO92/11033 Exemplary liposome and polycationic gene delivery vehicles are those described in US 5,422,120 and 4,762,915; in WO 95/13796; W094/23697; and W091/14445; in EP-0524968; and in Stryer, Biochemistry, pages 236-240 (1975) W.H. Freeman, San Francisco; Szoka (1980) Biochem Biophys Acta 600:1; Bayer (\91 ) Biochem Biophys Acta 550:464; Rivnay (1987) MetΛ Enzymol 149:119; Wang (1987) Proc Nat/ Aca Sci 84:7851 ; Plant (1989) Anal Biochem 176:420. A polynucleotide composition can comprises therapeutically effective amount of a gene therapy vehicle, as the term is defined above. For purposes of the present invention, an effective dose will be from about 0.01 mg/ kg to 50 mg/kg or 0.05 mg/kg to about 10 mg/kg of the DΝA constructs in the individual to which it is administered. Delivery Methods Once formulated, the polynucleotide compositions of the invention can be administered (1) directly to the subject; (2) delivered ex vivo, to cells derived from the subject; or (3) in vitro for expression of recombinant proteins. The subjects to be treated can be mammals or birds. Also, human subjects can be treated. Direct delivery of the compositions will generally be accomplished by injection, either subcutaneously, intraperitoneally, intravenously or intramuscularly or delivered to the interstitial space of a tissue. The compositions can also be administered into a lesion. Other modes of administration include oral and pulmonary administration, suppositories, and transdermal or transcutaneous applications (e.g., see WO98/20734), needles, and gene guns or hyposprays. Dosage treatment may be a single dose schedule or a multiple dose schedule. Methods for the ex vivo delivery and reimplantation of transformed cells into a subject are known in the art and described in e.g., W093/14778. Examples of cells useful in ex vivo applications include, for example, stem cells, particularly hematopoetic, lymph cells, macrophages, dendritic cells, or tumor cells. Generally, delivery of nucleic acids for both ex vivo and in vitro applications can be accomplished by the following procedures, for example, dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DΝA into nuclei, all well known in the art. Polynucleotide and polypeptide pharmaceutical compositions In addition to the pharmaceutically acceptable carriers and salts described above, the following additional agents can be used with polynucleotide and/or polypeptide compositions. A. Polypeptides One example are polypeptides which include, without limitation: asioloorosomucoid (ASOR); transferrin; asialoglycoproteins; antibodies; antibody fragments; ferritin; interleukins; interferons, granulocyte, macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), macrophage colony stimulating factor (M-CSF), stem cell factor and erythropoietin. Viral antigens, such as envelope proteins, can also be used. Also, proteins from other invasive organisms, such as the 17 amino acid peptide from the circumsporozoite protein of plasmodium falciparum known as R II. B. Hormones. Vitamins, etc. Other groups that can be included are, for example: hormones, steroids, androgens, estrogens, thyroid hormone, or vitamins, folic acid. C.Polyalkylenes. Polysaccharides. etc. Also, polyalkylene glycol can be included with the desired polynucleotides/polypeptides. In a preferred embodiment, the polyalkylene glycol is polyethlylene glycol. In addition, mono-, di-, or polysaccharides can be included. In a preferred embodiment of this aspect, the polysaccharide is dextran or DEAE-dextran. Also, chitosan and poly(lactide-co-glycolide) D. Lipids, and Liposomes The desired polynucleotide/polypeptide can also be encapsulated in lipids or packaged in liposomes prior to delivery to the subject or to cells derived therefrom. Lipid encapsulation is generally accomplished using liposomes which are able to stably bind or entrap and retain nucleic acid. The ratio of condensed polynucleotide to lipid preparation can vary but will generally be around 1:1 (mg DNA:micromoles lipid), or more of lipid. For a review of the use of liposomes as carriers for delivery of nucleic acids, see, Hug and Sleight (1991) Biochim. Biophys. Acta.1097:1-17; Straubinger (1983) Meth. Enzymol.101:512-527. Liposomal preparations for use in the present invention include cationic (positively charged), anionic (negatively charged) and neutral preparations. Cationic liposomes have been shown to mediate intracellular delivery of plasmid DNA (Feigner (1987) Proc. Natl. Acad. Sci. USA 84:7413-7416); mRNA (Malone (1989) Proc. Natl. Acad. Sci. USA 86:6077-6081); and purified transcription factors (Debs (1990) 7. Biol. Chem. 265:10189-10192), in functional form. Cationic liposomes are readily available. For example, N[l-2,3-dioleyloxy)propyl]-N,N,N-triethylammonium (DOTMA) liposomes are available under the trademark Lipofectin, from GIBCO BRL, Grand Island, NY. (See, also, Feigner supra). Other commercially available liposomes include transfectace (DDAB/DOPE) and DOTAP/DOPE (Boerhinger). Other cationic liposomes can be prepared from readily available materials using techniques well known in the art. See, e.g., Szoka (1978) Proc. Natl. Acad. Sci. USA 75:4194-4198; WO90/11092 for a description of the synthesis of DOTAP (l,2-bis(oleoyloxy)-3-(trimethylammonio)propane) liposomes. Similarly, anionic and neutral liposomes are readily available, such as from Avanti Polar Lipids (Birmingham, AL), or can be easily prepared using readily available materials. Such materials include phosphatidyl choline, cholesterol, phosphatidyl ethanolamine, dioleoylphosphatidyl choline (DOPC), dioleoylphosphatidyl glycerol (DOPG), dioleoylphoshatidyl ethanolamine (DOPE), among others. These materials can also be mixed with the DOTMA and DOTAP starting materials in appropriate ratios. Methods for making liposomes using these materials are well known in the art. The liposomes can comprise multilammelar vesicles (MLVs), small unilamellar vesicles (SUVs), or large unilamellar vesicles (LUVs). The various liposome-nucleic acid complexes are prepared using methods known in the art. See e.g., Straubinger (1983) Meth. Immunol.101:512-527; Szoka (1978) Proc. Natl. Acad. Sci. USA 75:4194-4198; Papahadjopoulos (1975) Biochim. Biophys. Acta 394:483; Wilson (1979) Cell 17:77); Deamer & Bangham (1976) Biochim. Biophys. Acta 443:629; Ostro (1977) Biochem. Biophys. Res. Commun.76:836; Fraley (1979) Proc. Natl. Acad. Sci. USA 76:3348); Enoch & Strittmatter (1979) Proc. Natl. Acad. Sci. USA 76:145; Fraley (1980) 7. Biol. Chem. (1980) 255:10431; Szoka & Papahadjopoulos (1978) Proc. Natl. Acad. Sci. USA 75:145; and Schaefer-Ridder (1982) Science 215:166. E.Lipoproteins In addition, lipoproteins can be included with the polynucleotide/polypeptide to be delivered. Examples of lipoproteins to be utilized include: chylomicrons, HDL, 1DL, LDL, and VLDL. Mutants, fragments, or fusions of these proteins can also be used. Also, modifications of naturally occurring lipoproteins can be used, such as acetylated LDL. These lipoproteins can target the delivery of polynucleotides to cells expressing lipoprotein receptors. Preferably, if lipoproteins are including with the polynucleotide to be delivered, no other targeting ligand is included in the composition. Naturally occurring lipoproteins comprise a lipid and a protein portion. The protein portion are known as apoproteins. At the present, apoproteins A, B, C, D, and E have been isolated and identified. At least two of these contain several proteins, designated by Roman numerals, Al, All, AIV; CI, CII, CHI. A lipoprotein can comprise more than one apoprotein. For example, naturally occurring chylomicrons comprises of A, B, C, and E, over time these lipoproteins lose A and acquire C and E apoproteins. VLDL comprises A, B, C, and E apoproteins, LDL comprises apoprotein B; and HDL comprises apoproteins A, C, and E. The amino acid of these apoproteins are known and are described in, for example, Breslow (1985) Annu Rev. Biochem 54:699; Law (1986) Adv. Exp Med. Biol. 151:162; Chen (1986) J Biol Chem 261:12918; Kane (1980) Proc Natl Acad Sci USA 77:2465; and Utermann (1984) Hum Genet 65:232. Lipoproteins contain a variety of lipids including, triglycerides, cholesterol (free and esters), and phospholipids. The composition of the lipids varies in naturally occurring lipoproteins. For example, chylomicrons comprise mainly triglycerides. A more detailed description of the lipid content of naturally occurring lipoproteins can be found, for example, in Meth. Enzymol. 128 (1986). The composition of the lipids are chosen to aid in conformation of the apoprotein for receptor binding activity. The composition of lipids can also be chosen to facilitate hydrophobic interaction and association with the polynucleotide binding molecule. Naturally occurring lipoproteins can be isolated from serum by ultracentrifugation, for instance. Such methods are described in Meth. Enzymol. (supra); Pitas (1980) 7. Biochem.255:5454-5460 and Mahey (1979) 7 Clin. Invest 64:743-750. Lipoproteins can also be produced by in vitro or recombinant methods by expression of the apoprotein genes in a desired host cell. See, for example, Atkinson (1986) Annu Rev Biophys Chem 15:403 and Radding (1958) Biochim Biophys Acta 30: 443. Lipoproteins can also be purchased from commercial suppliers, such as Biomedical Techniologies, Inc., Stoughton, Massachusetts, USA. Further description of lipoproteins can be found in Zuckermann et al. WO98/06437.. F. Polycationic Agents Polycationic agents can be included, with or without lipoprotein, in a composition with the desired polynucleotide/polypeptide to be delivered. Polycationic agents, typically, exhibit a net positive charge at physiological relevant pH and are capable of neutralizing the electrical charge of nucleic acids to facilitate delivery to a desired location. These agents have both in vitro, ex vivo, and in vivo applications. Polycationic agents can be used to deliver nucleic acids to a living subject either intramuscularly, subcutaneously, etc. The following are examples of useful polypeptides as polycationic agents: polylysine, polyarginine, polyornithine, and protamine. Other examples include histones, protamines, human serum albumin, DNA binding proteins, non-histone chromosomal proteins, coat proteins from DNA viruses, such as (X174, transcriptional factors also contain domains that bind DNA and therefore may be useful as nucleic aid condensing agents. Briefly, transcriptional factors such as C/CEBP, c-jun, c-fos, AP-1, AP-2, AP-3, CPF, Prot-1, Sp-1, Oct-1, Oct-2, CREP, and TFIID contain basic domains that bind DNA sequences. Organic polycationic agents include: spermine, spermidine, and purtrescine. The dimensions and of the physical properties of a polycationic agent can be extrapolated from the list above, to construct other polypeptide polycationic agents or to produce synthetic polycationic agents. Synthetic polycationic agents which are useful include, for example, DEAE-dextran, polybrene. LipofectinD, and lipofectAMINED are monomers that form polycationic complexes when combined with poly nucleotides/poly peptides. Immunodiasnostic Assays Meningogoccal antigens of the invention can be used in immunoassays to detect antibody levels (or, conversely, anti-meningococcal antibodies can be used to detect antigen levels). Immunoassays based on well defined, recombinant antigens can be developed to replace invasive diagnostics methods. Antibodies to meningococcal proteins within biological samples, including for example, blood or serum samples, can be detected. Design of the immunoassays is subject to a great deal of variation, and a variety of these are known in the art. Protocols for the immunoassay may be based, for example, upon competition, or direct reaction, or sandwich type assays. Protocols may also, for example, use solid supports, or may be by immunoprecipitation. Most assays involve the use of labeled antibody or polypeptide; the labels may be, for example, fluorescent, chemiluminescent, radioactive, or dye molecules. Assays which amplify the signals from the probe are also known; examples of which are assays which utilize biotin and avidin, and enzyme- labeled and mediated immunoassays, such as ELISA assays. Kits suitable for immunodiagnosis and containing the appropriate labeled reagents are constructed by packaging the appropriate materials, including the compositions of the invention, in suitable containers, along with the remaining reagents and materials (for example, suitable buffers, salt solutions, etc.) required for the conduct of the assay, as well as suitable set of assay instructions. Nucleic Acid Hybridisation "Hybridization" refers to the association of two nucleic acid sequences to one another by hydrogen bonding. Typically, one sequence will be fixed to a solid support and the other will be free in solution. Then, the two sequences will be placed in contact with one another under conditions that favor hydrogen bonding. Factors that affect this bonding include: the type and volume of solvent; reaction temperature; time of hybridization; agitation; agents to block the non-specific attachment of the liquid phase sequence to the solid support (Denhardt's reagent or BLOTTO); concentration of the sequences; use of compounds to increase the rate of association of sequences (dextran sulfate or polyethylene glycol); and the stringency of the washing conditions following hybridization. See Sambrook et al. [supra] Volume 2, chapter 9, pages 9.47 to 9.57. "Stringency" refers to conditions in a hybridization reaction that favor association of very similar sequences over sequences that differ. For example, the combination of temperature and salt concentration should be chosen that is approximately 120 to 200 DC below the calculated Tm of the hybrid under study. The temperature and salt conditions can often be determined empirically in preliminary experiments in which samples of genomic DNA immobilized on filters are hybridized to the sequence of interest and then washed under conditions of different stringencies. See Sambrook et al. at page 9.50. Variables to consider when performing, for example, a Southern blot are (1) the complexity of the DNA being blotted and (2) the homology between the probe and the sequences being detected. The total amount of the fragment(s) to be studied can vary a magnitude of 10, from 0.1 to lμg for a plasmid or phage digest to 10 "9 to 10 '8 g for a single copy gene in a highly complex eukaryotic genome. For lower complexity polynucleotides, substantially shorter blotting, hybridization, and exposure times, a smaller amount of starting polynucleotides, and lower specific activity of probes can be used. For example, a single-copy yeast gene can be detected with an exposure time of only 1 hour starting with 1 μ g of yeast DNA, blotting for two hours, and hybridizing for 4-8 hours with a probe of 10 8 cpm/μg. For a single-copy mammalian gene a conservative approach would start with 10 μg of DNA, blot overnight, and hybridize overnight in the presence of 10% dextran sulfate using a probe of greater than 10 8 cpm/μg, resulting in an exposure time of -24 hours. Several factors can affect the melting temperature (Tm) of a DNA-DNA hybrid between the probe and the fragment of interest, and consequently, the appropriate conditions for hybridization and washing. In many cases the probe is not 100% homologous to the fragment. Other commonly encountered variables include the length and total G+C content of the hybridizing sequences and the ionic strength and formamide content of the hybridization buffer. The effects of all of these factors can be approximated by a single equation: Tm= 81 + 16.6(log| 0 Ci) + 0.4[%(G + C)]-0.6(%formamide) - 600/n-l .5(% mismatch). where Ci is the salt concentration (monovalent ions) and n is the length of the hybrid in base pairs (slightly modified from Meinkoth & Wahl (1984) Anal. Biochem.138: 267-284). In designing a hybridization experiment, some factors affecting nucleic acid hybridization can be conveniently altered. The temperature of the hybridization and washes and the salt concentration during the washes are the simplest to adjust. As the temperature of the hybridization increases (i.e., stringency), it becomes less likely for hybridization to occur between strands that are nonhomologous, and as a result, background decreases. If the radiolabeled probe is not completely homologous with the immobilized fragment (as is frequently the case in gene family and interspecies hybridization experiments), the hybridization temperature must be reduced, and background will increase. The temperature of the washes affects the intensity of the hybridizing band and the degree of background in a similar manner. The stringency of the washes is also increased with decreasing salt concentrations. In general, convenient hybridization temperatures in the presence of 50% formamide are 42DC for a probe with is 95% to 100% homologous to the target fragment, 37DC for 90% to 95% homology, and 32DC for 85% to 90% homology. For lower homologies, formamide content should be lowered and temperature adjusted accordingly, using the equation above. If the homology between the probe and the target fragment are not known, the simplest approach is to start with both hybridization and wash conditions which are nonstringent. If non-specific bands or high background are observed after autoradiography, the filter can be washed at high stringency and reexposed. If the time required for exposure makes this approach impractical, several hybridization and/or washing stringencies should be tested in parallel. Nucleic Acid Probe Assays Methods such as PCR, branched DNA probe assays, or blotting techniques utilizing nucleic acid probes according to the invention can determine the presence of cDNA or mRNA. A probe is said to "hybridize" with a sequence of the invention if it can form a duplex or double stranded complex, which is stable enough to be detected. The nucleic acid probes will hybridize to the meningococcal nucleotide sequences of the invention (including both sense and antisense strands). Though many different nucleotide sequences will encode the amino acid sequence, the native meningococcal sequence is preferred because it is the actual sequence present in cells. mRNA represents a coding sequence and so a probe should be complementary to the coding sequence; single- stranded cDNA is complementary to mRNA, and so a cDNA probe should be complementary to the non- coding sequence. The probe sequence need not be identical to the meningococcal sequence (or its complement) — some variation in the sequence and length can lead to increased assay sensitivity if the nucleic acid probe can form a duplex with target nucleotides, which can be detected. Also, the nucleic acid probe can include additional nucleotides to stabilize the formed duplex. Additional meningococcal sequence may also be helpful as a label to detect the formed duplex. For example, a non-complementary nucleotide sequence may be attached to the 5' end of the probe, with the remainder of the probe sequence being complementary to a meningococcal sequence. Alternatively, non-complementary bases or longer sequences can be interspersed into the probe, provided that the probe sequence has sufficient complementarity with the a meningococcal sequence in order to hybridize therewith and thereby form a duplex which can be detected. The exact length and sequence of the probe will depend on the hybridization conditions, such as temperature, salt condition and the like. For example, for diagnostic applications, depending on the complexity of the analyte sequence, the nucleic acid probe typically contains at least 10-20 nucleotides, preferably 15-25, and more preferably at least 30 nucleotides, although it may be shorter than this. Short primers generally require cooler temperatures to form sufficiently stable hybrid complexes with the template. Probes may be produced by synthetic procedures, such as the triester method of Matteucci et al. [J. Am. Chem. Soc. (1981) 103:3185], or according to Urdea et al. [Proc. Natl. Acad. Sci. USA (1983) 80: 7461], or using commercially available automated oligonucleotide synthesizers. The chemical nature of the probe can be selected according to preference. For certain applications, DNA or RNA are appropriate. For other applications, modifications may be incorporated e.g., backbone modifications, such as phosphorothioates or methylphosphonates, can be used to increase in vivo half-life, alter RNA affinity, increase nuclease resistance etc. [e.g., see Agrawal & Iyer (1995) Curr Opin Biotechnol 6:12-19; Agrawal (1996) TIBTECH 14:376-387]; analogues such as peptide nucleic acids may also be used [e.g., see Corey (1997) TIBTECH 15:224-229; Buchardt et al. (1993) TIBTECH 11:384-386]. Alternatively, the polymerase chain reaction (PCR) is another well-known means for detecting small amounts of target nucleic acids. The assay is described in: Mullis et al. [Meth. Enzymol. (1987) 155: 335-350]; US patents 4,683,195 and 4,683,202. Two "primer" nucleotides hybridize with the target nucleic acids and are used to prime the reaction. The primers can comprise sequence that does not hybridize to the sequence of the amplification target (or its complement) to aid with duplex stability or, for example, to incorporate a convenient restriction site. Typically, such sequence will flank the desired meningococcal sequence. A thermostable polymerase creates copies of target nucleic acids from the primers using the original target nucleic acids as a template. After a threshold amount of target nucleic acids are generated by the polymerase, they can be detected by more traditional methods, such as Southern blots. When using the Southern blot method, the labelled probe will hybridize to the meningococcal sequence (or its complement). Also, mRNA or cDNA can be detected by traditional blotting techniques described in Sambrook et al [supra]. mRNA, or cDNA generated from mRNA using a polymerase enzyme, can be purified and separated using gel electrophoresis. The nucleic acids on the gel are then blotted onto a solid support, such as nitrocellulose. The solid support is exposed to a labelled probe and then washed to remove any unhybridized probe. Next, the duplexes containing the labeled probe are detected. Typically, the probe is labelled with a radioactive moiety. MODES FOR CARRYING OUT THE INVENTION - PREFERRED FRAGMENTS The protein sequences disclosed in the International Applications have been, inter alia, subjected to computer analysis to predict antigenic peptide fragments within the full-length proteins. Three algorithms have been used in this analysis: • AMPHI This program has been used to predict T-cell epitopes [Gao et al. (1989) J. Immunol.143:3007; Roberts et al. (1996) AIDS Res Hum Rerovir 12:593; Quakyi et al. (1992) Scand J Immunol suppl.11:9] and is available in the Protean package of DNASTAR, Inc. (1228 South Park Street, Madison, Wisconsin 53715 USA). • ANTIGENIC INDEX as disclosed by Jameson & Wolf (1988) The antigenic index: a novel algorithm for predicting antigenic determinants. CABIOS, 4:181:186 • HYDROPHILICITY as disclosed by Hopp & Woods (1981) Prediction of protein antigenic determinants from amino acid sequences. PNAS, 78:3824-3828 The three algorithms often identify the same fragments. Such multiply-identified fragments are particularly preferred. The algorithms often identify overlapping fragments (e.g., for antigen "013", AMPHI identifies aa 42-46, and Antigenic Index identifies aa 39-45). The invention explicitly includes fragments resulting from a combination of these overlapping fragments (e.g., the fragment from residue 39 to residue 46, in the case of "013"). Fragments separated by a single amino acid are also often identified (e.g., for "018-2", antigenic index identifies aa 19-23 and 25-41). The invention also includes fragments spanning the two extremes of such "adjacent" fragments (e.g., 19-41 for "081-2"). The Example provides preferred antigenic fragments of the proteins disclosed in the International Applications. Example 1 - Preferred Antigenic Protein Fragments The following amino acid sequences in Table 1 are identified by titles indicating the number assigned to the particular open reading frame (ORF), consistent with those designated in the International Applications. The titles are of the following form: [no prefix, g, or a] [#], where "no prefix" means a sequence from N. meningitidis serotype B, "a" means a sequence from N. meningitidis serotype A, and "g" means a sequence from N. gonorrhoeae; and "#" means the number assigned to that open reading frame (ORF). For example, "127" refers to an N. meningitidis B amino acid sequence, ORF number 127. The presence of a suffix "-1" or "-2" to these titles indicates an additional sequence found for that particular ORF. Thus, for example, "al2-2" refers to an N. meningitidis A amino acid sequence, ORF number 12, which is another sequence found for ORF 12 in addition to the originally designated ORF 12 and ORF 12-1. Each amino acid sequence is preceded by the beginning amino acid position number and followed by the ending amino acid position number. Table 1 012- 1 AMPHI Regions - AMPHI 19-LysLeu euGluGlnLeuMetArgPhe euGlnPhe euSerGluPheLeuPheAla euPheArgIle-41 48-ArgAla eu ysPheAlaArgArg-55 90-AsnPheIleArgHisThr-95 133-HisAlaAlaArgThrPhe-138 160-GlnGlyPheTyrGlyVal-165 179-GlyPheLeuArgPheGlyArgPheLeuProThrLeu euGlnThr eu-194 Antigenic Index - Jameson-Wolf 42-PheThrHis ysSerAsnArgAlaLeu ysPheAlaArgArgHisHis-57 77-HisThrHisArgThrAspAsnArg ysArgSerGlySerAsnPhe-91 93-ArgHisThrArgHis-97 101-AlaAlaArgArgHisLeuIleAspGlyAspGlyGlnArgAsn-114 120-ThrXxx ysLeuArgSerArgGlnThr-128 137-ThrPheGlnSerGluGlnAsn eu-144 147-ArgLeuGlyAsnGlnLysHisArgArgAsnLeuMetThrGln-160 173-IleGlnHisLysLysAlaGly-179 Hydrophilic Regions - Hopp-Woods 45- ysSerAsnArgAlaLeuLysPheAlaArgArgHisHis-57 77-HisThrHisArgThrAspAsnArg yεArgSerGly-88 lOl-AlaAlaArgArgHisLeuIleAspGlyAspGlyGlnArg-113 121-XxxLysLeuArgSerArgGln-127 149-GlyAsnGlnLysHisArgArgAsnLeu-157 173-IleGlnHis ysLysAlaGly-179 013 AMPHI Regions - AMPHI 42-AspSerTyrThrPhe-46 Antigenic Index - Jameson-Wolf 17-LysSerGluArgXxxSerGlyGlyAsnMetValProArgProSerProPheLeuPro-35 39-ThrGlnLeuAspSerTyrThr-45 58-GluAlaAlaAlaGlnLysGlnProLysThrArgAlaValGly-71 91-ArgSerGlyXxx ysIle-96 Hydrophilic Regions - Hopp-Woods 17-LysSerGluArgXxxSerGly-23 58-GluAlaAlaAlaGlnLysGlnProLysThrArgAlaValGly-71 015-2 AMPHI Regions - AMPHI 33-Glu ysProLeuAlaGlyPheTrpLysAla euProHis-45 107-MetCysCysValAlaCysIleVal-114 Antigenic Index - Jameson-Wolf 29-TrpLysAsnProGlu ysPro eu-36 90-MetArgAlaArgProArgSerThr ys-98 Hydrophilic Regions - Hopp-Woods 31-AsnProGluLysProLeu-36 90-MetArgAlaArgProArgSerThrLys-98 018-2 AMPHI Regions - AMPHI 6-IleGlnHis euArg-10 180-HisGlyCysGlnHisIlePhe-186 Antigenic Index - Jameson-Wolf l-MetValGluArgHisIleGln-7 9-LeuArgAsnGlyHis-13 19-ProSerGlnGlnVal-23 25-GlnMetPheGlyGlyArgAlaTyrAspPheArgAlaAspLysAlaAlaGly-41 67- yrPheAlaAspAsp ysPhe-73 78-LeuArgGlyAsnLeuArg-83 85-PheGlnThrAspLysAlaAspLeuArgThrGlyLysHisHisAlaAspGlyAlaAlaPro-104 106-ThrAlaAlaAspIleArgValAlaAla-114 129-GlnGlnArgGln euVal-134 137-IleAlaCysAspGluAspMetArgAsnThrGly euHis-149 151-GlnArgValGlyAsnArgTyrAla-158 Hydrophilic Regions - Hopp-Woods l-MetValGluArgHisIleGln-7 30-ArgAlaTyrAspPheArgAlaAspLysAlaAla-40 67-TyrPheAlaAspAspLysPhe-73 85-PheGlnThrAsp ysAlaAsp euArgThrGly ysHisHisAlaAspGlyAlaAla-103 106-ThrAlaAlaAspIleArgValAlaAla-114 137-IleAlaCysAspGluAspMetArgAsn-145 019-2 AMPHI Regions - AMPHI 33-ProAlaAspAsnIleGlu-38 60-AspTyrGlyGlyTyrProSerAlaLeuAspAla-70 80-AlaAlaTyrLeuGluAsnAlaGlyAsp-88 90-AlaMetAlaGluAsnValArgAsnGluTrpLeuLysSer-102 142-AlaAlaGluLeuValLysAsnThrGlyLysLeuProSerGlyCysThrLysLeuLeuGluGlnAlaAlaAla Ser-166 173-AspAlaTrpArgArgValArg-179 193-LeuAlaAlaAlaLeuGlyΞerProPheAspGlyGlyThrGlnGly-207 215-AsnValIleGlyLysGluAlaArgLysSer-224 229-AlaLeu euSerGluMet-234 259-AsnValProAlaAla euAspTyrTyrGly-268 292-ArgArgTrpAspGluLeuAlaSerValIleSerHisMetProGluLys euGln ys-310 329-GlnGluAlaGluLys euTyrLysGlnAla-338 367-AlaGlyLysAsnSerValArgArgMetAlaGlu-377 451-ArgTyrIleSerPro-455 495-GlnGlyLeuMetGlnValMet-501 582-ArgAspTyrValLys ysValMet-589 Antigenic Index - Jameson-Wolf 22-SerSerThrAsnThr-26 28-ProAlaGlyLysThrProAlaAspAsnIleGluThrAlaAspLeuSerAlaSerValProThrArgProAlaG luProGluArg ysThrLeuAlaAspTyrGlyGlyTyrProSerAla-67 69-AspAlaVal ysGln ysAsnAspAla-77 85-AsnAlaGlyAspSerAlaMet-91 103-LeuGlyAlaArgArgGln-108 115-GluTyrAla ysLeuGluProAlaGlyArgAlaGlnGluValGluCysTyrAlaAspSerSerArgAsnAsp TyrThrArgAlaAlaGluLeuValLysAsnThrGly ysLeuProSerGlyCys-156 167-GlyLeu euAspGlyAsnAspAlaTrpArgArgValArgGly-180 182-LeuAlaGlyArgGlnThrThrAspAlaArgAsn-192 199-SerProPheAspGlyGlyThrGlnGlySerArgGluTyr-211 217-IleGly ysGluAlaArgLysSerProAsnAla-227 232-SerGluMetGluSerGly euSerLeuGluGlnArgSer-244 254-GlnSerGlnAsn eu-258 266-TyrTyrGly ysValAlaAspArgArgGlnLeuThrAspAspGlnIle-281 287-AlaAla euArgAlaArgArgTrpAspGlu-296 304-MetProGluLys euGlnLysSerProThr-313 320-ArgSerArgAlaAlaThrGlyAsnThrGlnGluAlaGlu ys euTyr ys-336 339-AlaAlaThrGlyArgAsn-344 350-AlaGlyGluGlu euGlyArgLysIleAspThrArgAsnAsnValProAspAlaGly ysAsnSerValArg ArgMetAlaGluAspGlyAlaValLysArg-383 389-GlnAsnSerGlnSerAlaGlyAspAlaLysMetArgArgGlnAlaGlnAla-405 409-PheAlaThrArgGlyPheAspGluAsp ysLeu eu-420 438-SerAlaGluArgThrAspArgLysLeuAsnTyr-448 454-SerProPhe ysAspThrValIle-461 464-AlaGlnAsnValAsnValAspProAla-472 478-IleArgGlnGluSerArgPhe-484 488-AlaGlnSerArgValGlyAla-494 504-ThrAlaArgGluIleAlaGly-510 520-TyrThrAlaAspGlyAsnIleArgMetGly-529 535-AspThrLysArgArgLeuGlnAsnAsnGluVal-545 550-GlyTyrAsnAlaGlyProGlyArgAlaArgArgTrpGlnAlaAspThrProLeuGlu-568 579-SerGluThrArgAspTyrValLys-586 606-Leu ysGlnArgMet-610 Hydrophilic Regions - Hopp-Woods 30-GlyLysThrProAlaAspAsnIleGluThrAlaAspLeu-42 46-ValProThrArgProAlaGluProGluArgLysThrLeuAla-59 69-AspAlaValLysGln ysAsnAspAla-77 85-AsnAlaGlyAspSerAlaMet-91 103- euGlyAlaArgArgGln-108 115-GluTyrAlaLys euGluProAlaGlyArgAlaGlnGluValGluCysTyrAlaAspSerSerArgAsnAsp TyrThrArgAlaAlaGluLeuValLysAsnThrGly ysLeuProSerGlyCys-156 170-AspGlyAsnAspAlaTrpArgArgValArgGly-180 185-ArgGlnThrThrAspAlaArgAsn-192 201-PheAspGlyGlyThrGlnGlySerArgGlu-210 217-IleGly ysGluAlaArgLysSerProAsn-226 232-SerGluMetGluSer-236 238- euSerLeuGluGlnArgSer-244 270-ValAlaAspArgArgGln euThrAspAspGlnIle-281 287-AlaAlaLeuArgAlaArgArgTrpAspGlu-296 304-MetProGluLysLeuGlnLys-310 320-ArgSerArgAlaAlaThr-325 327-AsnThrGlnGluAlaGluLysLeuTyr ys-336 350-AlaGlyGluGluLeuGlyArg ysIleAspThrArgAsnAsnValProAspAlaGlyLysAsnSerValArg ArgMetAlaGluAspGlyAlaVal ysArg-383 392-GlnSerAlaGlyAspAlaLysMetArgArgGlnAlaGlnAla-405 411-ThrArgGlyPheAspGluAspLysLeuLeu-420 438-SerAlaGluArgThrAspArgLys eu-446 478-IleArgGlnGluSerArgPhe-484 504-ThrAlaArgGluIleAlaGly-510 535-AspThrLysArgArgLeuGlnAsn-542 554-GlyProGlyArgAlaArgArgTrpGlnAla-563 579-SerGluThrArgAspTyrValLys-586 606-LeuLysGlnArgMet-610 023 AMPHI Regions - AMPHI 42-LysGluTyrSerAlaTrpGlnAlaPhePheSerGlnThrTrpValLysValPheThrGlnValSerPheIleA laValPhe euHisAlaTrpValGly-74 77-AspLeuTrpMetAspTyr11eLys-84 Antigenic Index - Jameson-Wolf l-MetValGluArg ys euThr-7 40-LeuProLysGluTyrSer-45 Hydrophilic Regions - Hopp-Woods l-MetValGluArgLysLeuThr-7 025-2 AMPHI Regions - AMPHI 9-AlaAlaCysThrAlaValAlaAlaLeuLeuGlyGlyCysAla-22 36-MetGlnAspAlaProSerSerAlaValTyrAsnAsnProTyrGlyAla-51 126-AspPheArgAlaTrpAsnGlyMetThrAsp-135 140-IleGlyGlnIleVal ysVal-146 206-AspPheArgAlaTrpAsnGlyMetThrAspAsnMet-217 219-SerIleGlyGlnIleValLysVal-226 248-AlaValGlnThrProValLysProAlaAla-257 261-ValGlnSerAlaProGlnPro-267 290-SerGlyThrArgSer-294 307-LysValValAlaAspPhe-312 343-Gly euArgGlyTyrGlyAsn-349 Antigenic Index - Jameson-Wolf 22-AlaThrGlnGlnPro-26 33-AsnSerGlyMetGlnAspAlaProSerSer-42 52-ThrProTyrSerProAlaProAlaGlyAspAlaProTyr-64 108-ValArgGlyAspThr-112 115-AsnIleSerI_ysArgTyrHisIleSerGlnAspAspPheArgAla-129 131-AsnGlyMetThrAspAsnThrLeu-138 144-Val ysVal ysProAlaGly-150 157-AlaAlaVal ysSerArgProAlaVal-165 170-GlnProProValGln-174 188-ValArgGlyAspThr-192 195-AsnIleSerLysArgTyrHisIleSerGlnAspAspPheArgAla-209 211-AsnGlyMetThrAspAsnMetLeu-218 224-Val ysValLysProAlaGly-230 232-AlaAlaProLysThrAlaAlaValGluSerArgProAlaValPro-246 252-ProValLysProAlaAlaGlnProProValGlnSerAlaProGlnPro-267 270-ProAlaAlaGluAsn ysAlaValPro-278 280-ProAlaProGlnSerProAlaAlaSerProSerGlyThrArgSerValGly-296 302-ArgProThrGlnGlyLysValValAlaAspPheGlyGlyAsnAsn ysGlyValAsp-320 333-AlaAspGly ysVal-337 342-SerGly euArgGlyTyrGly-348 363-TyrGlyHisAsnGln-367 370- euValGlyGluGlyGlnGlnValLysArgGlyGlnGln-382 387-GlyAsnThrAspAlaSerArgThrGln eu-396 398-PheGluValArgGlnAsnGlyLysProValAsnProAsnSer-411 Hydrophilic Regions - Hopp-Woods 35-GlyMetGlnAspAlaProSer-41 108-ValArgGlyAspThr-112 120-TyrHisIleSerGlnAspAspPheArg-128 144-ValLysValLysPro-148 157-AlaAlaValLysSerArgProAlaVal-165 188-ValArgGlyAspThr-192 200-TyrHisIleSerGlnAspAspPheArg-208 224-ValLysValLysPro-228 237-AlaAlaValGluSerArgProAlaVal-245 253-ValLysProAlaAla-257 270-ProAlaAlaGluAsn ysAlaValPro-278 290-SerGlyThrArgSer-294 313-GlyGlyAsnAsnLysGlyValAsp-320 333-AlaAspGlyLysVal-337 373-GluGlyGlnGlnValLysArgGlyGln-381 389-ThrAspAlaSerArgThr-394 400-ValArgGlnAsnGlyLysProValAsn-408 031 AMPHI Regions - AMPHI 11-TyrSerAlaIleArgLeuPheThrGlnAlaValIleGluPheProGlnThrAlaGluHisCysArgArgThrA rgAsp-36 48-ArgArgProValGln-52 Antigenic Index - Jameson-Wolf 1-Arg euLysHisGlyVal-6 25-ProGlnThrAlaGluHisCysArgArgThrArgAspGlnHisGlnGluArgArgAsnArgGlnGlyPheArgA rgProValGlnHisValGlyArgArgAsnGlnGlnGlnArgHisSerGlnThrCysGlyGlnSerGlyArgAsnHi sAlaGln ysGlnGlnCysAlaThrArgGln-84 Hydrophilic Regions - Hopp-Woods 28-AlaGluHisCysArgArgThrArgAspGlnHisGlnGluArgArgAsnArgGlnGlyPheArgArgProVal- 51 54-ValGlyArgArgAsnGlnGlnGlnArgHisSerGln-65 69-GlnSerGlyArgAsnHisAlaGlnLysGlnGlnCysAlaThrArgGln-84 032-2 AMPHI Regions - AMPHI ll-LeuArgArgProLeuArgGln-17 67-ProPheAlaAspAsnValTyrPro-74 94-ThrAlaAlaValHisGlnPheGluGln-102 114-ValHisGlyGlnIleGlnHisProValGlnProPheLeuArg-127 134-LeuGlyLeuLeuArgArgPheAspVal-142 Antigenic Index - Jameson-Wolf 1-MetArgArgAsnVa1-5 10-ValLeuArgArgPro euArg-16 28-ArgAlaValProAlaGly ysGlnGlyPhe-37 41-CysArg euThrGlnArgGln-47 57-AlaAspGlnArgHis-61 107-HisArgGlnArgVal-lll 138-ArgArgPheAspValGlyGlyArgVal-146 160- euProProArgArgLysLeuAlaSerGlnArgProPheProGln-174 Hydrophilic Regions - Hopp-Woods l-MetArgArgAsnVal-5 10-ValLeuArgArgProLeuArg-16 28-ArgAlaValProAlaGlyLys-34 41-CysArgLeuThrGln-45 57-AlaAspGlnArgHis-61 107-HisArgGlnArgVal-lll 138-ArgArgPheAspValGlyGly-144 161-ProProArgArgLysLeuAlaSer-168 033-2 AMPHI Regions - AMPHI 6-GlnTyrGlyGlyLeuAlaGlyPheProLysArgCysGluSerGlu-20 64-GlyGlnAlaPheGluAlaLeuAsnCys-72 95-ValGlyAlaLeuProLysTyrLeuAlaSerAsnValValArgAspMetHisGlyLeuLeuSerThrVal-117 120-GlnThrGlyLysValLeuAspLysIleProGlyAlaMetGlu-133 142-IleLysThrLeuAlaGlu-147 157-SerLeuPheGluAsnPhe-162 168-GlyProValAspGlyHisAsnValGluAsnLeuValAspValLeuLysAspLeuArgSerArg-188 207-AlaGluAsnAspPro-211 213-LysTyrHisAlaValAlaAsnLeuProLysGluSerAlaAla-226 242-TyrThrGlnValPheGlyLys-248 280-PheProAspArgTyrPheAspVal-287 307-LysProValValAlaIleTyrSer-314 316-PheLeuGlnArgAlaTyrAspGlnLeu-324 363-CysValProAsnMet-367 390-AlaProAlaAlaValArgTyrProArgGlyThr-400 406-ValSerAspGlyMetGluThrValGlu-414 419-IleIleArgArgGlu-423 432-PheGlySerMetValAla-437 453-MetArgPheValLysProIleAspGluGlu-462 469-ArgSerHisAspArgIle-474 489-AlaValLeuGluValLeu-494 510-AspThrValThrGlyHisGly-516 518-ProLysLysLeuLeu-522 Antigenic Index - Jameson-Wolf ll-AlaGlyPheProLysArgCysGluSerGluTyrAspAla-23 28-HisSerSerThrSerIle-33 41-AlaAlaAspLysLeuLeuGlySerAspArgArgSerVal-53 57-GlyAspGlyAlaMetThr-62 72-CysAlaGlyAspMetAspVal-78 85-AsnAspAsnGluMetSerIle-91 105-AsnValValArgAspMetHisGly-112 117-ValLysAlaGlnThrGlyLysValLeuAspLysIleProGly-130 134-PheAlaGlnLysValGluHisLysIleLysThrLeuAlaGluGluAlaGluHisAlaLysGln-154 166-TyrThrGlyProValAspGlyHisAsn-174 181-ValLeuLysAspLeuArgSerArgLysGlyProGln-192 198-ThrLysLysGlyAsnGlyTyrLysLeuAlaGluAsnAspProValLys-213 220-LeuProLysGluSerAlaAla-226 228-MetProSerGluLysGluProLysProAlaAlaLysProThrTyr-242 253-ArgAlaAlaAlaAspSerArgLeu-260 266-AlaMetArgGluGlySerGlyLeuValGluPheGluGlnArgPheProAspArgTyrPhe-285 345-ValGlyAlaAspGlyProThrHis-352 370-AlaAlaProSerAspGluAsnGluCysArg-379 395-ArgTyrProArgGlyThrGlyThrGlyAlaProValSerAspGlyMetGluThrValGluIleGlyLysGly IleIleArgArgGluGlyGluLysThrAla-428 457-LysProIleAspGluGluLeuIle-464 467-LeuAlaArgSerHisAspArgIleValThrLeuGluGluAsnAlaGluGlnGlyGlyAlaGlyGly-488 512-ValThrGlyHisGlyAspProLysLysLeuLeuAspAspLeuGlyLeu-527 530-GluAlaValGluArgArgValArg-537 540-LeuSerAspArgAspAlaAlaAsn-547 Hydrophilic Regions - Hopp-Woods 13-PheProLysArgCysGluSerGluTyrAsp-22 41-AlaAlaAspLysLeuLeuGlySerAspArgArgSerVal-53 74-GlyAspMetAspVal-78 85-AsnAspAsnGluMetSerIle-91 106-ValValArgAspMetHis-lll 123-LysValLeuAspLysIleProGly-130 134-PheAlaGlnLysValGluHisLysIleLysThrLeuAlaGluGluAlaGluHisAlaLysGln-154 181-ValLeuLysAspLeuArgSerArgLysGlyPro-191 198-ThrLysLysGlyAsnGly-203 205-LysLeuAlaGluAsnAspProValLys-213 220-LeuProLysGluSerAlaAla-226 228-MetProSerGluLysGluProLysProAlaAla-238 253-ArgAlaAlaAlaAspSerArgLeu-260 266-AlaMetArgGluGlySerGly-272 274-ValGluPheGluGlnArgPheProAspArgTyrPhe-285 372-ProSerAspGluAsnGluCys-378 405-ProValSerAspGlyMetGluThrValGluIleGlyLysGlyIleIleArgArgGluGlyGluLysThrAla -428 457-LysProIleAspGluGluLeuIle-464 467-LeuAlaArgSerHisAspArgIleValThrLeuGluGluAsnAlaGluGlnGlyGly-485 513-ThrGlyHisGlyAspProLysLysLeuLeuAsp-523 530-GluAlaValGluArgArgValArg-537 540-LeuSerAspArgAspAlaAlaAsn-547 034-2 AMPHI Regions - AMPHI 35-LeuAspHisAlaAla-39 52-AsnLeuGluGlnMetArgAlaIleMetGluAlaAlaAspGln-65 94-AlaValGluGluPheProHisIlePro-102 152-ThrValValAsnPheSer-157 168-IleGlyValLeuGlyAsnLeuGluThrGly-177 186-GlyAlaValGlyLysLeuSer-192 226-TyrLysPheThrArgProProThrGly-234 236-ValLeuArgIleAspArgIleLysGluIleHisGlnAlaLeu-249 261-SerValProGlnGluTrpLeuLysValIleAsnGluTyrGlyGlyAsnIleGlyGluThrTyrGlyValPro ValGluGluIleValGluGlyIleLysHisGly-295 314-ArgArgTyrLeuAlaGluAsn-320 330-LeuSerLysThrIleGluAlaMetLys-338 Antigenic Index - Jameson-Wolf 20-LeuProLysGluThrGln-25 37-HisAlaAlaGluAsnSerTyrGly-44 54-GluGlnMetArgAlaIleMetGluAlaAlaAspGlnValAsp-67 75-SerAlaGlyAlaArgLysTyrAla-82 106-HisGlnAspHisGlyAlaSerProAspValCysGlnArgSerIle-120 129-MetAspGlySerLeuMetGluAspGlyLysThrProSerSerTyrGluTyr-145 164-ValGluGlyGluIle-168 173-AsnLeuGluThrGlyGluAlaGlyGluGluAspGlyVal-185 191-LeuSerHisAspGln-195 208-LysAspThrGlyVal-212 221-ThrSerHisGlyAla-225 227-LysPheThrArgProProThrGlyAspValLeuArgIleAspArgIleLysGluIleHis-246 258-GlySerSerSerValPro-263 271-AsnGluTyrGlyGlyAsnIleGlyGlu-279 287-GluIleValGluGlyIleLysHisGlyValArgLysValAsnIleAspThrAspLeuArgLeuAlaSerThr GlyAlaVal-313 316-TyrLeuAlaGluAsnProSerAspPheAspProArgLysTyrLeuSer-331 333-ThrIleGluAlaMetLys-338 350-CysGluGlyGlnAlaGlyLysIleLysProValSerLeuGluLysMetAlaSerArgTyrAlaLysGlyGlu Leu-374 Hydrophilic Regions - Hopp-Woods 54-GluGlnMetArgAlaIleMetGluAlaAlaAspGlnValAsp-67 76-AlaGlyAlaArgLysTyrAla-82 108-AspHisGlyAlaSerProAspValCysGln-117 132-SerLeuMetGluAspGlyLysThrProSer-141 164-ValGluGlyGluIle-168 175-GluThrGlyGluAlaGlyGluGluAspGlyVal-185 208-LysAspThrGlyVal-212 235-AspValLeuArgIleAspArgIleLysGluIleHis-246 287-GluIleValGluGlyIleLysHisGlyValArgLysValAsnIleAspThrAspLeuArgLeu-307 32O-AsnProSerAspPheAspProArgLysTyrLeu-330 333-ThrIleGluAlaMetLys-338 352-GlyGlnAlaGlyLysIleLysProValSerLeuGluLysMetAlaSerArgTyrAlaLysGlyGluLeu-37 4 036-1 AMPHI Regions - AMPHI 6-AlaValTyrSerAlaCysAlaAla-13 29-GlyArgCysValAsnGlnTyr-35 59-SerSerGlyArgPheCysGlnThrIleLys-68 106-AlaAlaSerSerSerGlnSer-112 142-AlaAsnArgArgVal-146 Antigenic Index - Jameson-Wolf 16-ProAlaArgThrSerSerSerArgArgCysValSerSerGlyArgCysValAsnGlnTyrSerSerArgAlaA spAla-41 43-ProTrpArgArgHisSerGlyAla-50 55-CysSerSerAspSerSerGlyArgPhe-63 73-ProSerPheSerAlaArgLysThrCysSerAspGlyGluThrSerAlaAspSerAsnTrpArg-93 96-HisAlaAspGlyLeuGlnThrAlaSerSerAlaAlaSerSerSerGlnSerAlaGlnThrAlaArgArgMetP he-120 133-SerGlyArgPheCysCysGlyArgArgAlaAsnArgArgValArgHisGlyArgGlnAspAsnArgPro-15 5 158-ProMetArgGluSerArgArgGlnSerAla-167 178-LeuProAlaArgThrArgCys-184 186-CysArgLeuLysArgArglleProProAla-195 200-ProProAlaArgProAspAsnArgSerAsnGlyGlySerSerAlaTyrArgThrMetHisLysThrLeuArg ProTyrGluArgPro-228 Hydrophilic Regions - Hopp-Woods 18-ArgThrSerSerSerArgArgCysValSerSer-28 35-TyrSerSerArgAlaAsp-40 45-ArgArgHisSerGly-49 55-CysSerSerAspSerSerGlyArg-62 75-PheSerAlaArgLysThrCysSerAspGlyGluThrSerAla-88 107-AlaSerSerSerGlnSer-112 114-GlnThrAlaArgArgMe Phe-120 137-CysCysGlyArgArgAlaAsnArgArgValArgHisGlyArgGlnAspAsnArgPro-155 160-ArgGluSerArgArgGlnSer-166 178-LeuProAlaArgThrArgCys-184 186-CysArgLeuLysArgArgIleProPro-194 202-AlaArgProAspAsnArgSerAsnGlyGly-211 217-ThrMetHisLysThrLeuArgProTyrGluArgPro-228 038 AMPHI Regions - AMPHI 100-GluAlaLysAspHis-104 134-GluSerIleLys-137 157-GluLysGlyThrGlyGluLeuSerAlaValGlnGluValGluLys-171 178-AlaProIleAlaSerLeuAsn-184 195-GluPheGlyGlnPheLeuGluProValArgAlaTyrArgArgGlnTyrGlyVal-212 Antigenic Index - Jameson-Wolf 2-ThrAspPheArgGlnAspPhe-8 22-GluPheThrThrLysAlaGlyArgArgSerPro-32 38-GlyLeuPheAsnAspGlyLeu-44 58-IleGluSerGlyIleArg-63 85-LeuAlaGluLysGlyVal-90 96-TyrAsnArgLysGluAlaLysAspHisGlyGluGlyGly-108 125-ValIleSerAlaGlyThrSerValArgGluSerIleLysLeuIleGluAlaGluGlyAlaThrLeuAspArg MetGluLysGlyThrGlyGlu-162 167-GlnGluValGluLysGlnTyrGlyLeu-175 191-GlnAsnAsnProGluPheGlyGln-198 203-ValArgAlaTyrArgArgGlnTyrGlyValGlu-213 Hydrophilic Regions - Hopp-Woods 2-ThrAspPheArgGlnAspPhe-8 22-GluPheThrThrLysAlaGlyArgArgSer-31 85-LeuAlaGluLysGlyVal-90 96-TyrAsnArgLysGluAlaLysAspHisGlyGlu-106 130-ThrSerValArgGluSerIleLysLeuIleGluAlaGluGlyAlaThr-145 153-LeuAspArgMetGluLysGlyThrGlyGlu-162 167-GlnGluValGluLysGlnTyr-173 204-ArgAlaTyrArgArgGInTyrGly-211 040-2 AMPHI Regions - AMPHI 8-ValAlaHisPheArgGluAlaValProTyrIleArg-19 28-AlaGlyIleAspAsp-32 38-AspThrLeuAsnLysLeu-43 78-ProHisTyrCysArgGlyLeuArgValThrAspGlu-89 92-LeuGluGlnAlaGlnGlnPheAlaGly-lOO 113-SerValSerGlyPheAlaArgAlaPro-121 134-ArgProIleGlyValIleAspGly-141 146-TyrAlaGlyValIleArg-151 187-LeuGlnThrAlaAla-191 207-LeuSerAspGlyIleSerArgProAspGlyThrLeuAlaGlu-220 223-SerAlaGlnGluAlaGlnSerLeuAlaGluHisAla-234 244-SerAlaValAlaAlaLeuGluGly-251 277-IleGlyThrSerIle-281 289-IleArgGlnAlaHisSerGlyAspIleProHisIleAlaAlaLeuIleArgProLeuGlu-308 320-TyrLeuGluAsnHisIleSerGluPheSerIle-330 338-TyrGlyCysAlaAlaLeuLysThrPheAlaGluAlaAsp-350 371-ArgLeuLeuAlaHisIle-376 386-SerArgLeuPheAla-390 Antigenic Index - Jameson-Wolf 19-ArgGlnMetArgGlyLysThrLeu-26 29-GlyIleAspAspArgLeuLeuGluGlyAspThrLeuAsn-41 65-HisPheLeuAspArgHisAlaAlaAlaGlnGlyArgThrProHisTyrCysArgGlyLeuArgValThrAspG luThrSerLeuGluGlnAlaGln-96 101-ThrValArgSerArgPheGlu-107 119-ArgAlaProSerVal-123 140- spGlyThr spMetGluTyr-146 150-IleArgLysThrAspThrAlaAla-157 173-LeuGlyHisSerTyrSerGlyLysThrPhe-182 208-SerAspGlyIleSerArgProAspGlyThrLeuAla-219 222-LeuSerAlaGlnGluAlaGlnSerLeuAlaGluHisAlaGlyGlyGluThrArgArgLeuIle-242 249-LeuGluGlyGlyVal-253 261-GlyAlaAlaAspGlySerLeuLeu-268 272-PheThrArgAsnGlyIleGlyThrSerIleAlaLysGluAlaPheVal-287 289-IleArgGlnAlaHisSerGlyAspIle-297 305-ArgProLeuGluGluGlnGly-311 313-LeuLeuHisArgSerArgGluTyrLeu-321 331-LeuGluHisAspGlyAsnLeuTyr-338 345-ThrPheAlaGluAlaAspCysGlyGlu-353 361-ProGlnAlaGlnAspGlyGlyTyrGlyGluArgLeu-372 377-IleAspLysAlaArgGly-382 393 -ThrAsnThrGlyGlu-397 402-ArgGlyPheGlnThrAlaSerGluAspGluLeuProGluThrArgArgLysAspTyrArgSerAsnGlyArg AsnSerHisIleLeu-430 Hydrophilic Regions - Hopp-Woods 19-ArgGlnMetArgGlyLysThr-25 29-GlyIleAspAspArgLeuLeuGluGlyAspThrLeuAsn-41 65-HisPheLeuAspArgHisAlaAlaAlaGlnGlyArgThr-77 84-LeuArgValThrAspGluThrSerLeuGluGln-94 102-ValArgSerArgPheGlu-107 140-AspGlyThrAspMetGluTyr-146 150-IleArgLysThrAspThrAlaAla-157 210-GlyIleSerArgProAspGlyThrLeu-218 222-LeuSerAlaGlnGluAlaGlnSerLeuAlaGlu-232 234-AlaGlyGlyGluThrArgArgLeuIle-242 291-GlnAlaHisSerGlyAsp-296 305-ArgProLeuGluGluGlnGly-311 315-HisArgSerArgGluTyrLeu-321 345-ThrPheAlaGluAlaAspCysGlyGlu-353 362-GlnAlaGlnAspGlyGlyTyrGlyGlu-370 377-IleAspLysAlaArgGly-382 402-ArgGlyPheGlnThrAlaSerGluAspGluLeuProGluThrArgArgLysAspTyrArgSerAsnGlyArg Asn-426 041-1 AMPHI Regions - AMPHI 6-AspProTyrArgHisPheGluAsnLeuAspSerAlaGluThr-19 45-AspGlyIleLeuAla-49 78-LysGlyValTyrArgValCysThrAlaAla-87 102-ValAlaAspPheAspGluLeuLeu-109 117-GlyValSerHisLeuValGluGlnProAsn-126 219-ValAsnAlaTrpArgTyrLeuAsp-226 232-IleAspLeuIleGluAlaSer-238 258-LeuAsnLeuProAsnAspCysAspValValGlyTyrLeu-270 282-TrpAsnArgAlaAsnGln-287 317-GlnAlaLeuGluSerValGluThr-324 331-AlaSerLeuLeuGluAsnValGlnGlyArg-340 382-AspPheThrThrProLeu-387 405-GlnProGlnGlnPhe-409 451-GlyPheGlyIleProGluLeuProHisTyrLeuGlySerIleGlyLys-466 493-AlaAlaGlnGlyIleSerLysHisLysSerValAspAspLeuLeuAlaValValArgAspLeuSerGluArg -516 519-SerSerProGluHis-523 541-ValArgGluProGlnSer-546 556-LeuThrAspMetIleArgTyr-562 571-TrpThrAspGluTyrGlyAsnProGlnLysTyrGlu-582 591-LeuSerProTyrHisAsnLeuSerAspGlyIleAspTyrProPro-605 620-AlaHisAlaLeuLys-624 626-TyrAlaLysLeuArg-630 645-GlyHisThrGlyAsn-649 651-ThrGlnArgGluSer-655 Antigenic Index - Jameson-Wolf l-MetLysSerTyrProAspProTyrArgHisPheGluAsnLeuAspSerAlaGluThrGln-20 26-AlaAsnAlaGluThrArgAlaArgPheLeuGluAsnAspLysAlaArgAlaLeuSerAspGly-46 51-LeuGlnAspThrArgGlnIleProPhe-59 61-GlnGluHisArgAlaArg-66 72-GlnAspAlaGluTyrProLysGlyVal-80 89-TyrArgSerGlyTyrProGluTrp-96 104- spPheAspGluLeuLeuGlyAspAspValTyr-114 123-GluGlnProAsnArg-127 133-SerLysLeuGlySerAspThrAlaTyr-141 145-ValAspLeuGluAlaGlyGluLeuValGlu-154 161-AlaGlyLysAsnHisValSerTrpArgAspGluAsnSerVal-174 178-ProAlaTrpAsnGluArgGlnLeuThrGlnSerGlyTyrProArgGluValTrpLeuValGluArgGlyLys SerPheGluGluSerLeu-207 212-IleGlyGluAspGlyMet-217 223-ArgTyrLeuAspProGlnGlySerProIleAspLeuIleGluAlaSerAspGlyPheTyr-242 249-ValSerAlaGluGlyGluAlaLysProLeuAsnLeuProAsnAspCysAspVal-266 277-ThrLeuArgLysAspTrpAsnArgAlaAsnGlnSerTyrProSer-291 298-LysLeuAsnArgGlyGluLeuGly-305 313-ProAspGluThrGlnAla-318 32O-GluSerValGluThrThrLys-326 337-ValGlnGlyArgLeuLysAla-343 345-ArgPheAlaAspGlyLysTrpGlnGluValGluLeuProArgLeuProSerGly-362 365-GluMetThrAspGlnProTrpGlyGly-373 401-ValMetArgArgGlnProGlnGlnPheAspSerAspGlyIleAsn-415 422-ThrSerAlaAspGlyGluArgIle-429 435-GlyLysAsnAlaAlaProAspMet-442 479-AsnIleArgGlyGlyGlyGluPheGlyProArgTrpHis-491 496-GlyIleSerLysHisLysSerValAspAsp-505 511-ArgAspLeuSerGluArgGlyIleSerSerProGluHisIle-524 G528-lyGlySerAsnGly-532 540-PheValArgGluProGlnSerIleGlyAla-549 568-GlySerSerTrpThrAspGluTyrGlyAsnProGlnLysTyrGluValCysLysArgArgLeuGlyGluLeu SerProTyr-594 596-AsnLeuSerAspGlyIleAspTyrPro-604 610-ThrSerLeuSerAspAspArgValHis-618 627-AlaLysLeuArgGluThrSerAla-634 639-TyrSerProAspGlyGlyGlyHisThrGlyAsnGlyThrGlnArgGluSerAlaAspGluLeu-659 Hydrophilic Regions - Hopp-Woods 3-SerTyrProAspProTyrArgHis-10 12-GluAsnLeuAspSerAlaGluThr-19 26-AlaAsnAlaGluThrArgAlaArgPheLeuGluAsnAspLysAlaArgAlaLeuSer-44 52-GlnAspThrArgGln-56 61-GlnGluHisArgAlaArg-66 72-GlnAspAlaGluTyrPro-77 104-AspPheAspGluLeuLeuGly-llO 145-ValAspLeuGluAlaGlyGluLeuValGlu-154 166-ValSerTrpArgAspGluAsnSer-173 180-TrpAsnGluArgGlnLeuThr-186 198-GluArgGlyLysSerPheGluGluSerLeu-207 212-IleGlyGluAspGlyMet-217 233-AspLeuIleGluAlaSerAsp-239 249-ValSerAlaGluGlyGluAlaLysPro-257 278-LeuArgLysAspTrpAsnArg-284 298-LysLeuAsnArgGlyGluLeuGly-305 313-ProAspGluThrGlnAla-318 320-GluSerValGluThrThrLys-326 337-ValGlnGlyArgLeuLysAla-343 401-ValMetArgArgGlnProGlnGlnPheAspSerAspGlyIleAsn-415 424-AlaAspGlyGluArg-428 436-LysAsnAlaAlaProAsp-441 481-ArgGlyGlyGlyGluPheGly-487 496-GlyIleSerLysHisLysSerValAspAsp-505 511-ArgAspLeuSerGluArgGlyIleSerSer-520 540-PheValArgGluProGlnSer-546 571-TrpThrAspGluTyrGlyAsn-577 579-GlnLysTyrGluValCysLysArgArgLeuGlyGlu-590 612-LeuSerAspAspArgValHis-618 627-AlaLysLeuArgGluThrSer-633 650-GlyThrGlnArgGluSerAlaAspGluLeu-659 042-1 AMPHI Regions - AMPHI 17-AlaLeuSerAsnThrSerThr-23 33-AlaValArgSerMetMetLysIle-40 138-SerProLeuValArgIleLeuProLeuSer-147 151-SerMetValValAlaPhePheAlaAsn-159 Antigenic Index - Jameson-Wolf 14-ArgThrSerAlaLeuSerAsnThrSerThrAlaAlaGlyProSerCys-29 49-TyrSerLysGluThrGlyCysProCysProSerLeuArgLysAspSerSerThrGlyGlyArgProMetSerP roCys-74 77-LeuAlaAsnArgAspCysValProLysAlaAspThr-88 93-ThrAspSerThrSerProArgProLeu-101 122-AlaArgAlaSerLeuProLysIleArgAlaLysVal-133 160-CysSerTyrAlaSerAlaProGlyPro-168 Hydrophilic Regions - Hopp-Woods 49-TyrSerLysGluThrGlyCys-55 59-SerLeuArgLysAspSerSerThrGlyGlyArgProMet-71 78-AlaAsnArgAspCysValProLysAlaAspThr-88 94-AspSerThrSerProArg-99 125-SerLeuProLysIleArgAlaLysVal-133 043-2 AMPHI Regions - AMPHI 24-ValGluProSerArg-28 36-HisGlyGlyLeuAspGlyAlaAlaGlyPheAspGluGlyGluArg-50 59-AlaSerGlyAspGlyPhe-64 83-AlaGlyAspPheGlyAspGlyGlnArg-91 Antigenic Index - Jameson-Wolf l-MetProProAlaPro-5 H-IleArgArgGlnLysSerValMetProSerGluArgPheValGluProSerArg-28 35-ValHisGlyGlyLeuAspGlyAlaAlaGlyPheAspGluGlyGluArgValPhe-52 56-AlaAlaGlnAlaSerGlyAspGlyPheAla-65 79-GlnSerAspAlaAlaGlyAspPheGlyAspGlyGlnArgThrGlyGlu-94 96-ValLeuGlnAspValGlyGly-102 116-AlaGluGlyGluAlaGln-121 Hydrophilic Regions - Hopp-Woods H-IleArgArgGlnLysSerValMetProSerGluArgPheValGluProSerArg-28 43-AlaGlyPheAspGluGlyGluArgValPhe-52 81-AspAlaAlaGlyAspPheGlyAspGlyGlnArgThrGly-93 116-AlaGluGlyGluAlaGln-121 046-2 AMPHI Regions - AMPHI 6-ArgProThrSerSerPro-ll 46-ThrSerCysSerGlyLeuMetValSer-54 64-PheSerLeuPheSerSer-69 113-LysSerAlaSerSer-117 143-SerCysAsnAlaPheSerSer-149 155-ThrSerLeuLeuGlyMetAlaAlaArgPheCysAlaThrVal-168 Antigenic Index - Jameson-Wolf 6-ArgProThrSerSerProProArgArgAlaCys-16 20-IleArgThrArgSerSerAlaLysArgLysThrCysAsnAlaProGlyGlnSerIleArgProAlaSerCysS er-44 57-ProAsnMetGluArgLeuPro-63 75-SerArgTyrSerLeuGluArgThrArgAlaMetArgProGlyMetLeuAsnArgSerAlaAla-95 105-SerLeuArgGluSerAlaSerSerLysSerAlaSerSerAlaProAlaArgSerAsnValLysGlyAspAla ProLeuProLysThrValTrpThrSerArgArgLeuProVal-142 169-GluProThrCysProLeuProLys-176 Hydrophilic Regions - Hopp-Woods 7-ProThrSerSerProProArgArgAlaCys-16 20-11eArgThrArgSerSerAlaLysArgLysThrCysAsn-32 36-GlnSerIleArgProAlaSer-42 58-AsnMetGluArgLeuPro-63 75-SerArgTyrSerLeuGluArgThrArgAlaMetArg-86 105-SerLeuArgGluSerAlaSerSerLysSerAlaSer-116 118-AlaProAlaArgSerAsnValLysGlyAspAlaProLeu-130 047-2 AMPHI Regions - AMPHI 17-IleAlaAspIleAlaGlnAspLeuProAspGlyAla-28 62-AlaGluAsnIleGlyAlaVal-68 93-ArgLeuAlaLysGlnLeuGlu-99 141-TyrIleAspGluIleAspValPhe-148 161-SerAlaLeuLeuAla-165 185-LeuLeuGluGlyAsn-189 202-IleGlySerIleLeuAla-207 247-SerGlyIleLysTrpProGluGlyCys-255 257-IleAlaAlaValValArgAlaGlyThrGly-266 293-IleLeuAsnGluLeuGluLysLeuIle-301 Antigenic Index - Jameson-Wolf 5-GlnAlaArgArgGlyGlyLeuLeu-12 20-IleAlaGlnAspLeuProAspGlyAlaAsp-29 36-TyrArgAsnAsnArgLeu-41 51-IleGluGlyAspGlu-55 70-ProGluLeuArgProLysGluThrSerThrArgArgIleMet-83 86-GlyGlyGlyAsnIle-90 96-LysGlnLeuGluHis-100 106-IleIleGluCysArgProArgArgAlaGluTrpIle-117 119-GluAsnLeuAspAsnThrLeu-125 130-SerAlaThrAspGluThrLeuLeuAspAsnGluTyrIleAspGluIleAsp-146 152-ThrAsnAspAspGluSerAsnIle-159 168-LeuGlyAlaLysArgVal-173 178-AsnArgSerSerTyr-182 186-LeuGluGlyAsnLysIle-191 208-HisIleArgArgGlyAspIleVal-215 219-ProIleArgArgGlyThrAlaGluAlaIleGlu-229 232-AlaHisGlyAspLysLysThrSer-239 242-IleGlyArgArgIleSerGlyIleLysTrpProGluGlyCysHis-256 262-ArgAlaGlyThrGlyGluThr-268 277-ValIleGlnAspGlyAspHis-283 288-ValSerArgArgArgIleLeuAsnGluLeuGluLys-299 Hydrophilic Regions - Hopp-Woods 5-GlnAlaArgArgGlyGly-10 20-IleAlaGlnAspLeuProAspGlyAlaAsp-29 51-IleGluGlyAspGlu-55 70-ProGluLeuArgProLysGluThrSerThrArgArgIleMet-83 106-IleIleGluCysArgProArgArgAlaGluTrpIle-117 130-SerAlaThrAspGluThrLeuLeu-137 140-GluTyrIleAspGluIleAsp-146 152-ThrAsnAspAspGluSerAsnIle-159 168-LeuGlyAlaLysArgVal-173 186-LeuGluGlyAsnLysIle-191 209-IleArgArgGlyAspIle-214 219-ProIleArgArgGlyThrAlaGluAlaIleGlu-229 232-AlaHisGlyAspLysLysThrSer-239 242-IleGlyArgArgIleSer-247 277-ValIleGlnAspGlyAsp-282 289-SerArgArgArgIleLeuAsnGluLeuGluLys-299 049-2 AMPHI Regions - AMPHI 15-GlnHisLeuLeuGlu-19 34-AspAspAlaValAspGlyIleGlyGlnMet-43 50-GlnProPheGlyGln-54 61-GluHisPheAlaProValAspGlyPheArg-70 79-HisGlnArgPhePheArgIle-85 202-ArgGlyAlaGlyGlnArgArgValSerArgHisCys-213 217-AlaArgLeuThrGlnValPheGlnThrPhePhe-227 Antigenic Index - Jameson-Wolf 6-PheAspTyrArgProArgLeuLeu-13 21-IleGlyGluAsnArgHis-26 28-LeuLeuHisArgArgSerAspAspAlaValAspGlyIleGly-41 49-AspGlnProPheGly-53 64-AlaProValAspGlyPheArgValGlnAspIleAspLeuAspGlyHisGlnArgPhe-82 89-ValPheArgAsnArgArgLeuIle-96 lll-LeuSerGlyPheLys-115 122-GlyIleLysProAspSerProProArgPhe-131 135-PheArgAsnArgHisLeuGlnGlySerLeuArgVal-146 150-PheLeuLysAspAspHisArgValGly-158 182-GlnHisThrGlySer-186 193-ArgHisArgArgValArgSerGlyPheArgGlyAlaGlyGlnArgArgValSerArgHisCys-213 246-LysGlnThrAsnProArgProLysArgGlyLeu-256 Hydrophilic Regions - Hopp-Woods 21-IleGlyGluAsnArgHis-26 30-HisArgArgSerAspAspAlaValAsp-38 67-AspGlyPheArgValGlnAspIleAspLeuAspGlyHisGlnArg-81 91-ArgAsnArgArgLeuIle-96 124-LysProAspSerProProArg-130 150-PheLeuLysAspAspHisArgVal-157 193-ArgHisArgArgValArgSerGlyPheArgGlyAlaGlyGlnArgArgValSerArg-211 246-LysGlnThrAsnProArgProLysArgGlyLeu-256 050-1 AMPHI Regions - AMPHI lO-IleGlnSerIleCysAspAlaPheGlnPheIleSerTyrTyr-23 25-ProLysAspTyrIleAspAlaLeuTyrLysAlaTrpGlnLys-38 94-ValAsnGluGlyVal-98 163-AsnProSerAspAsnIleValAspTrpValLeuLys-174 177-ProThrMetGlyAla-181 235-LeuGluLeuPheGluLysValAsnAla-243 250-GlyLeuGlyGlyLeuThrThr-256 275-AlaMetIleProAsn-279 302-ArgValGluAspTrpProAspLeuThr-310 315-AsnGlyLysArgValAspValAsp-322 353-LysArgLeuValAspMetLeuAsnLys-361 367-ValAspPheThrAsnArgLeu-373 379-ProValAspProValGlyAspGlu-386 396-AlaThrArgMetAspLysPheThrArgGlnMet-406 410-ThrAspLeuLeuGlyMet-415 422-GlyValAlaThrCysGluAlaIleAla-430 452-LysSerSerLysValLeuAlaPhe-459 490-AlaThrAlaProArgLysTrp-496 Antigenic Index - Jameson-Wolf 4-IleLysGlnGluAspPheIle-10 23-TyrHisProLysAspTyrIleAspAlaLeu-32 36-TrpGlnLysGluGluAsnProAlaAlaLysAspAlaMet-48 55-SerArgMetCysAlaGluAsnAsnArgProIleCysGlnAspThrGly-70 88-MetSerValGluGluMetValAsnGluGlyValArgArgAlaTyrThrTrpGluGlyAsnThrLeuArgAlaS erVal-113 116-AspProAlaGlyLysArgGlnAsnThrLysAspAsnThr-128 138-ProGlyGlyLysValGluVal-144 148-AlaLysGlyGlyGlySerGluAsnLysSerLysLeu-159 163-AsnProSerAspAsnIle-168 192-GlyIleGlyGlyThrProGluLysAlaValLeuMetAlaLysGluSerLeu-208 213-AspIleGlnGluLeuGlnGluLysAlaAlaSerGlyAlaGluLeuSerThr-229 284-ArgHisValGluPheGluLeuAspGlySerGlyProValGluLeuThrProProArgValGluAspTrpPro AspLeuThrTyrSerProAspAsnGlyLysArgValAspValAspLysLeuThrLysGluGluValAlaSer-331 345-LeuThrGlyArgAspAlaAlaHisLysArgLeuVal-356 359-LeuAsnLysGlyGluGluLeuPro-366 379-ProValAspProValGlyAspGluValValGlyProAlaGlyProThrThrAlaThrArgMetAspLysPhe ThrArgGlnMetLeuGluGlnThrAsp-411 417-GlyLysSerGluArgGlyValAlaThr-425 428-AlaIleAlaAspAsnLysAla-434 450-AlaIleLysSerSerLys-455 470-PheGluValLysAspMetPro-476 481-ValAspSerLysGlyGluSerIle-488 492-AlaProArgLysTrpGlnAla-498 Hydrophilic Regions - Hopp-Woods 4-IleLysGlnGluAspPheIle-10 36-TrpGlnLysGluGluAsnProAlaAlaLysAspAlaMet-48 57-MetCysAlaGluAsnAsnArgProIleCys-66 88-MetSerValGluGluMetValAsnGluGlyValArgArg-100 117-ProAlaGlyLysArgGlnAsnThrLysAspAsnThr-128 140-GlyLysValGluVal-144 148-AlaLysGlyGlyGlySerGluAsnLysSerLysLeu-159 195-GlyThrProGluLysAlaValLeuMetAlaLysGluSerLeu-208 213-AspIleGlnGluLeuGlnGluLysAlaAlaSer-223 225-AlaGluLeuSerThr-229 284-ArgHisValGluPheGluLeuAspGly-292 299-ThrProProArgValGluAspTrpPro-307 313-ProAspAsnGlyLysArgValAspValAspLysLeuThrLysGluGluValAlaΞer-331 345-LeuThrGlyArgAspAlaAlaHisLysArgLeuVal-356 359-LeuAsnLysGlyGluGluLeuPro-366 382-ProValGlyAspGluValVal-388 397-ThrArgMetAspLysPheThrArgGlnMetLeuGluGlnThrAsp-411 417-GlyLysSerGluArgGlyValAla-424 428-AlaIleAlaAspAsnLysAla-434 450-AlaIleLysSerSerLys-455 470-PheGluValLysAspMetPro-476 481-ValAspSerLysGlyGluSerIle-488 492-AlaProArgLysTrpGlnAla-498 052 AMPHI Regions - AMPHI 12-AlaProCysPheLysGlyCysGluProThrGlyAsp-23 41-AlaLysAlaSerLysSerAlaThrSerProLysGlyLeuAspGlyValSerLys-58 67-ThrAlaAlaPheHisSerPheIleSer-75 84-Me ProAsnLeuValThrMetLeu-91 Antigenic Index - Jameson-Wolf 4-ValAlaGluGluThrGluIle-10 14-CysPheLysGlyCysGluProThrGlyAspSerArgLeuLeuSerThrThrLysSerAlaPro-34 37-CysAlaAsnSerAlaLysAlaSerLysSerAlaThrSerProLysGlyLeuAspGlyValSerLysAsnSerS er-61 75-SerValGlyAspThrArgLeuThrProMet-84 97-ValValProAsnArgLeuArgLeuGluThrThrTrpSerProAlaCysArgLysValLysAsnAlaAla-119 Hydrophilic Regions - Hopp-Woods 4-ValAlaGluGluThrGluIle-10 16-LysGlyCysGluProThrGlyAspSerArgLeu-26 30-ThrLysSerAlaPro-34 39-AsnSerAlaLysAlaSerLysSerAlaThrSerProLysGlyLeuAspGlyValSerLysAsnSer-60 77-GlyAspThrArgLeu-81 100-AsnArgLeuArgLeu-104 111-AlaCysArgLysValLysAsnAlaAla-119 075 AMPHI Regions - AMPHI 15-LysSerAlaAlaLysMetProThrThrIleGlnProAlaSerIleProSer-31 65-AlaProTyrLeuArgGlnValLeu-72 80-PheLysLysCysLeuAla-85 116-AspPhePheGlnThrCysValAsnArgPhePheGluValValGluIleIleGlyIleGly-135 Antigenic Index - Jameson-Wolf 12-GluAsnThrLysSerAlaAlaLysMetPro-21 52-AlaLysAlaArgGly-56 91-PhePheArgArgProProAsnIleArgLysSerValPheGlnLysSerGluTyrAspLys-110 Hydrophilic Regions - Hopp-Woods 12-GluAsnThrLysSerAlaAlaLys-19 52-AlaLysAlaArgGly-56 91-PhePheArgArgProProAsnl1eArgLysSerValPheGlnLysSerGluTyrAspLys-110 080 AMPHI Regions - AMPHI 6-GluAlaMetGluArgLeuThrArg-13 95-PheProAspThrValGlu-100 108-ProValAlaArgTrpGlyAspHis-115 144-SerAlaGluMetLeuArgArgTyrAspGluPheSerThrValLeu-158 195-LysArgLeuArgLeuPheThrGluAlaTrpGlnHis-206 Antigenic Index - Jameson-Wolf l-MetTrpAspAsnAlaGluAlaMetGluArgLeuThr-12 33 -AsnSerAsnHisLeuPro-38 42-ValSerLeuLysGly-46 48-LeuValTyrSerAspLysLysThrLeu-56 67-AsnIleLeuArgThrAspIleAsnGlyAlaGlnGluAlaTyrArg-81 90-MetValArgArgArgPheProAspThrValGlu-100 103-LeuThrGluArgLysProValAlaArgTrpGly-113 116-AlaLeuValAspGlyGluGlyAsnValPhe-125 127-AlaArgLeuAspArgProGlyMetPro-135 138-ArgGlyAlaGluGlyThrSer-144 146-GluMetLeuArgArgTyrAspGlu-153 163-LeuGlyIleLysGlu-167 187-ArgLeuGlyArgGluAsnGluMetLysArgLeuArgLeu-199 207-LeuLeuArgLysAsnLysAsnArgLeuSer-216 220-MetArgTyrLysAspGlyPheSer-227 230-TyrAlaSerAspGlyLeuProGluLysGluSerGluGlu-242 Hydrophilic Regions - Hopp-Woods 3-AspAsnAlaGluAlaMetGluArgLeuThr-12 50-TyrSerAspLysLysThrLeu-56 69-LeuArgThrAspl1eAsnGlyAlaGlnGluAlaTyrArg-81 90-MetValArgArgArgPheProAspThrVal-99 103-LeuThrGluArgLysProValAlaArgTrpGly-113 116-AlaLeuValAspGlyGluGlyAsnValPhe-125 127-AlaArgLeuAspArgProGly-133 138-ArgGlyAlaGluGlyThrSer-144 146-GluMetLeuArgArgTyrAspGlul53153 163-LeuGlyIleLysGlu-167 187-ArgLeuGlyArgGluAsnGluMetLysArgLeuArgLeu-199 208-LeuArgLysAsnLysAsnArgLeuSer-216 220-MetArgTyrLysAspGlyPheSer-227 234-GlyLeuProGluLysGluSerGluGlu-242 081 AMPHI Regions - AMPHI 22-LysProValSerArgIleValThrAspSer-31 85-LeuAlaAlaLeuGlnThrLeuAlaLysAlaTrpArgGluAsn-98 116-LysGluMetLeuAlaAlaValLeuArg-124 135-ThrAlaGlyAsnPhe-139 165-MetAsnHisPheGlyGluLeuAlaValLeuThrXxxIleAlaLys-179 185-ValAsnAsnAlaMetArg-190 198-AspGlyValGlyAspIleAlaLysAla-206 303-LeuAsnAspValAlaGluGlyLeuLysGlyPheSerAsnIle-316 345-AlaAlaIleAspValLeuAlaArgMetPro-354 360-ValMetGlyAspMetGlyGluLeuGlyGluLeuGlyGlu-372 402-ValGluAlaAlaGlu-406 Antigenic Index - Jameson-Wolf 16-ProMetProSerGluSerLysProValSer-25 27-IleValThrAspSerArgAspIleArgAlaGlyAsp-38 44-AlaGlyGluArgPheAspAla-50 67-ValSerArgGluAspCysAlaAla-74 77-GlyAlaLeuLysValAspAspThrLeu-85 94-AlaTrpArgGluAsnValAsnProPhe-102 108-GlySerGlyGlyLysThrThrValLysGluMetLeu-119 123-LeuArgArgArgPheGlyAspAspAlaVal-132 138-AsnPheAsnAsnHisIle-143 151-LysLeuAsnGluLysHisArg-157 178-AlaLysProAsnAla-182 194-GlyCysGlyPheAspGlyValGlyAspIleAlaLysAlaLysSerGluIle-210 212-GlnGlyLeuCysSerAspGly-218 223-ProGlnGluAspAlaAsn-228 239-LeuAsnThrArgThrPheGlyIleAspSerGlyAspValHisAla-253 269-CysGlyAspGluArgAlaAla-275 280-ValProGlyArgHisAsnVal-286 305-AspValAlaGluGlyLeuLys-311 313-PheSerAsnIleLysGlyArgLeuAsnValLysSerGlyIleLysGly-328 330-ThrLeuIleAspAspThrTyrAsnAlaAsnProAspSerMetLysAlaAla-346 363-AspMetGlyGluLeuGlyGluLeuGlyGluAspGluAlaAla-376 384-AlaTyrAlaArgAspGlnGlyIle-391 398-GlyAspAsnSerValGluAlaAlaGluLysPheGlyAla-410 425-LeuArgHisAspLeuProGluArgAlaThrVal-435 437-ValLysGlySerArg-441 446-GluGluValValGluAlaLeuGluAspLys-455 Hydrophilic Regions - Hopp-Woods 17-MetProSerGluSerLysProValSer-25 27-IleValThrAspSerArgAspIleArgAla-36 44-AlaGlyGluArgPheAspAla-50 67-ValSerArgGluAspCysAlaAla-74 77-GlyAlaLeuLysValAspAspThrLeu-85 94-AlaTrpArgGluAsnVal-99 109-SerGlyGlyLysThrThrValLysGluMetLeu-119 123-LeuArgArgArgPheGlyAsp-129 151-LysLeuAsnGluLysHisArg-157 199-GlyValGlyAspIleAlaLysAlaLysSerGluIle-210 223-ProGlnGluAspAlaAsn-228 247-AspSerGlyAspValHisAla-253 269-CysGlyAspGluArgAlaAla-275 305-AspValAlaGluGlyLeuLys-311 316-IleLysGlyArgLeuAsnVal-322 335-ThrTyrAsnAlaAsnProAspSerMetLysAlaAla-346 363-AspMetGlyGluLeuGlyGluLeuGlyGluAspGluAlaAla-376 384-AlaTyrAlaArgAspGlnGlyIle-391 400-AsnSerValGluAlaAlaGluLysPheGlyAla-410 425-LeuArgHisAspLeuProGluArgAlaThrVal-435 446-GluGluValValGluAlaLeuGluAspLys-455 084-2 AMPHI Regions - AMPHI 6-ArgIleLysAsnMetAsnGlnThrLeuLysAsnThrLeuGly-19 21-CysAlaLeuLeuAla-25 48-AlaValGlyAlaLeuAla-53 65-PheProArgValSer-69 96-GlnIleValGlySerIleLeuGluSer-104 lll-GluPheValGlyAsnLeuProGly-118 Antigenic Index - Jameson-Wolf l-MetLysGlnSerAlaArgIleLysAsnMetAsnGlnThrLeuLysAsnThr-17 40-TyrGluTyrGlyTyrArgTyrSer-47 102-LeuGluSerAsnProAlaGluAlaArgGluPheValGly-114 139-ValSerGlyGlyGly-143 Hydrophilic Regions - Hopp-Woods l-MetLysGlnSerAlaArgIleLysAsnMetAsnGlnThrLeu-14 105-AsnProAlaGluAlaArgGluPheVal-113 085-2 AMPHI Regions - AMPHI 41-GluArgValSerGlnIleGlyLysMetPheAspGlyLeu-53 60-LeuLysAspAlaLeuAspAsnGlyPheAεp-69 90-AsnGlyGlyArgValLeuGlyAspIleGluLeuLeuAlaAsp-103 125-ThrSerLeuValGlyTyr-130 141-IleAlaGlyAsnIleGlyThr-147 174-GluAsnThrGluSerLeu-179 193-HisLeuAspArgTyrAspAspLeuLeuAspTyr-203 212-ArgGlyAspGlyValGln-217 225-PheCysArgAlaMetLysArgAla-232 275-HisAsnAlaAlaAsnValMetAlaAlaValAlaLeuCysGluAla-289 300-HisValLysThrPheGlnGlyLeuProHisArgValGluLysIleGly-315 336-AlaAlaIleAlaGlyLeu-341 353-GlyLysGlyGlnAspPheThr-359 395-AspCysAlaThrLeuGlyGluAlaValGlnThr-405 424-SerPheAspMetPheLysGlyTyr-431 Antigenic Index - Jameson-Wolf 4-GlnAsnLysLysIleLeu-9 23-TyrLeuArgLysAsnGlyAlaGluValAlaAlaTyrAspAlaGluLeuLysProGluArgValSerGlnIleG lyLysMetPheAsp-51 58-GlyArgLeuLysAspAlaLeuAspAsnGlyPhe-68 74-SerProGlyIleSerGluArgGlnProAspIleGluAlaPheLysGlnAsnGlyGlyArgValLeuGly-96 104-11eVa1AsnArgArgAspAspLysVallle-113 116-ThrGlySerAsnGlyLysThrThr-123 153-GluTrpGlnArgGluGlyLysLysAlaAsp-162 169-ΞerSerPheGlnLeuGluAsnThrGluSerLeuArgProThrAla-183 189-IleSerGluAspHisLeuAspArgTyrAspAspLeuLeu-201 204-AlaHisThrLysAlaLysIlePheArgGlyAspGlyVal-216 220-AsnAlaAspAspAlaPheCysArgAlaMetLysArgAlaGlyArgGluValLys-237 247-PheTrpLeuGluArgGluThrGlyArgLeuLysGlnGlyAsnGluAspLeuIleVal-265 29l-GlyLeuSerArgGluAlaLeu-297 307-LeuProHisArgValGluLysIleGlyGluLysAsnGly-319 322-PheIleAspAspSerLysGlyThrAsnVal-331 351-GlyMetGlyLysGlyGlnAspPheThrProLeuArgAspAlaLeuValGlyLysAlaLys-370 378-AspAlaProGlnlleArgArgAspLeuAspGlyCysGly-390 431-TyrAlaHisArgSer-435 Hydrophilic Regions - Hopp-Woods 4-GlnAsnLysLysIleLeu-9 25-ArgLysAsnGlyAlaGlu-30 32-AlaAlaTyrAspAlaGluLeuLysProGluArgValSerGln-45 59-ArgLeuLysAspAlaLeuAspAsnGlyPhe-68 76-GlyIleSerGluArgGlnProAspIleGluAlaPheLysGlnAsnGlyGly-92 104-IleValAsnArgArgAspAspLysVal-112 118-SerAsnGlyLysThrThr-123 153-GluTrpGlnArgGluGlyLysLysAlaAsp-162 174-GluAsnThrGluSerLeuArgPro-181 189-IleSerGluAspHisLeuAspArgTyrAspAspLeuLeu-201 204-AlaHisThrLysAlaLysIlePheArgGlyAspGly-215 220-AsnAlaAspAspAlaPheCysArgAlaMetLysArgAlaGlyArgGluValLys-237 247-PheTrpLeuGluArgGluThrGlyArgLeuLysGlnGlyAsnGluAspLeuIleVal-265 291-GlyLeuSerArgGluAlaLeu-297 309-HisArgValGluLysIleGlyGluLysAsnGly-319 324-AspAspSerLysGlyThrAsn-330 353-GlyLysGlyGlnAsp-357 359-ThrProLeuArgAspAlaLeuValGlyLysAlaLys-370 380-ProGlnlleArgArgAspLeuAspGly-388 431-TyrAlaHisArgSer-435 086-2 AMPHI Regions - AMPHI 55-MetArgThrTrpArgArgLeuValPro-63 83-IleAsnGlyAlaThrArg-88 99-ProThrGluLeuPheLysLeuAlaVal-107 120-GluValLeuArgSerMetGluSerLeuGlyTrpGlnSerIleTrpArgGlyThrAlaAsn-139 155-GluMetTyrGlyArgPhe-160 185-SerPheValValIle-189 228-ArgValGlnArgValValAlaPheLeuAspProTrpLysAspProGln-243 293-GlyPhePheGlyMetCys-298 336-TrpIleGlyIleGlnSerPhe-342 Antigenic Index - Jameson-Wolf 20-LeuAlaSerLysGluGlyGlyAsp-27 55-Me ArgThrTrpArgArg-60 79-AlaGlyArgGluIleAsnGlyAlaThr-87 115-PheThrArgArgGluGluValLeuArgSerMetGlu-126 134-TrpArgGlyThrAla-138 144-AlaThrAsnProGlnAlaArgArgGluThrLeuGluMet-156 225-AlaProTyrArgVal-229 236-LeuAspProTrpLysAspProGlnGlyAla-245 265-GlyLeuGlyAlaSerLeuSerLysArgGlyPheLeu-276 313-SerIleGlyLysGlnSerArgAspLeuGly-322 352-LeuProThrLysGlyLeu-357 382-IleAspTyrGluAsnArgArgLysMetArgGlyTyrArgValGlu-396 Hydrophilic Regions - Hopp-Woods 21-AlaSerLysGluGlyGlyAsp-27 79-AlaGlyArgGluIleAsnGly-85 115-PheThrArgArgGluGluValLeuArgSerMetGlu-126 147-ProGlnAlaArgArgGluThrLeuGluMet-156 238-ProTrpLysAspProGlnGly-244 27O-LeuSerLysArgGlyPheLeu-276 316-LysGlnSerArgAspLeu-321 382-IleAspTyrGluAsnArgArgLysMetArgGlyTyrArgValGlu-396 087-2 AMPHI Regions - AMPHI 23-ValAlaAspSerLeuArg-28 80-GlnThrValArgGluAlaGlnArgIleIle-89 99-GlyPheGlyGlyPheValThrPheProGlyGlyLeuAlaAlaLysLeuLeu-115 129-GlyLeuSerAsnArgHisLeuSerArgTrpAlaLysArgValLeuTyrAlaPheProLys-148 157-ValGlyAsnProValArg-162 192-GlyAlaAspValLeuAsnLysThrVal-200 241-ValGluPheIleThrAspMetValSerAlaTyr-251 313-GluLysLeuAlaGluIleLeuGly-320 330-TrpAlaGluAsnAla-334 Antigenic Index - Jameson-Wolf 25-AspSerLeuArgAlaArgGly-31 37-LeuGlySerLysAspSerMetGluGluArgIleValProGlnTyrGlyIle-53 61-LysGlyValArgGlyAsnGlyIleLysArgLysLeu-72 81-ThrValArgGluAlaGlnArgIleIleArgLysHisArgVal-94 130-LeuSerAsnArgHisLeuSerArgTrpAlaLys-140 150-PheSerHisGluGlyGlyLeu-156 159-AsnProValArgAlaAspIleSer-166 171-ProAlaGluArgPheGlnGlyArgGluGlyArgLeu-182 195-ValLeuAsnLysThrVal-200 207-LeuProAspAsnAlaArgProGlnMetTyrHisGlnSerGlyArgGlyLysLeuGly-225 229-AlaAspTyrAspAla-233 235-GlyValLysAlaGluCys-240 249-SerAlaTyrArgAspAlaAsp-255 284-AlaValAspAspHisGlnThrAla-291 309-GlnLeuThrAlaGluLysLeuAlaGlu-317 321-GlyLeuAsnArgGluLysCysLeuLys-329 331-AlaGluAsnAlaArgThr-336 341-HisSerAlaAspAspValAlaGlu-348 Hydrophilic Regions - Hopp-Woods 25-AspSerLeuArgAlaArgGly-31 39-SerLysAspSerMetGluGluArgIleVal-48 66-AsnGlyIleLysArgLysLeu-72 81-ThrValArgGluAlaGlnArgIleIleArgLysHisArgVal-94 134-HisLeuSerArgTrpAlaLys-140 161-ValArgAlaAspIle-165 171-ProAlaGluArgPheGlnGlyArgGluGlyArgLeu-182 219-SerGlyArgGlyLysLeu-224 235-GlyValLysAlaGluCys-240 249-SerAlaTyrArgAspAlaAsp-255 284-AlaValAspAspHisGlnThrAla-291 310-LeuThrAlaGluLysLeuAlaGlu-317 322-LeuAsnArgGluLysCysLeuLys-329 331-AlaGluAsnAlaArg-335 341-HisSerAlaAspAspValAlaGlu-348 088-2 AMPHI Regions - AMPHI 7-HisPheSerAsnTrpLeuThrGlyLeuAsnIlePheGlnTyrThrThr-22 24-ArgAlaValMetAlaAlaLeu-30 43-ThrIleArgArgLeuThrAlaLeuLysCysGlyGln-54 88-LeuTrpGlyAsnTrpAlaAsn-94 Hl-GlyPheTyrAspAspTrpArgLysValValTyr-121 140-AlaIleIleAlaSerLeuAlaLeu-147 175-GlyPheLeuValLeuSerTyrLeuThrIle-184 187-ThrSerAsnAlaValAsnLeuThrAspGlyLeuAspGlyLeuAlaThr-202 221-HisSerGlnPheAlaGlnTyrLeuGlnLeuProTyr-232 245-AlaMetCysGlyAlaCysLeuGlyPhe-253 Antigenic Index - Jameson-Wolf 48-ThrAlaLeuLysCysGlyGlnAlaValArgThrAspGlyProGln-62 66-ValLysAsnGlyThrProThrMet-73 114-AspAspTrpArgLysValValTyrLysAspProAsnGlyValSerAlaLysPhe-131 193 -LeuThrAspGlyLeuAsp-198 312-LysLysThrLysLysArgIle-318 328-TyrGluGlnLysGlyTrpLysGluThrGlnVal-338 Hydrophilic Regions - Hopp-Woods 56-ValArgThrAspGlyProGln-62 114-AspAspTrpArgLysValValTyrLysAspProAsnGlyVal-127 312-LysLysThrLysLysArgIle-318 331-LysGlyTrpLysGlu-335 089-2 AMPHI Regions - AMPHI 40-PheSerThrArgCysGlyArgProTrpLysValLeu-51 74-LeuAlaAlaLeuCysArgProCysAsnGlyMetSerCys-86 118-SerArgProAlaArgPhe-123 Antigenic Index - Jameson-Wolf 1-Me ProProLysIleThrLysSerGlyPhe-lO 40-PheSerThrArgCysGlyArgProTrpLys-49 54-SerSerAsnAlaSerArgAspLysProMetAlaSerHisLysAla-68 79-ArgProCysAsnGlyMetSerCys-86 95-CysPheArgArgProValSerArgSerAsnGlnLysSerAlaSerCysSerAsnGluAsnHisPheThrSerA rgProAlaArgPhelleAlaArgGlnAsnAlaSerSerAlaPheLysThrCysThrProSerProArgLysIleLe u-144 Hydrophilic Regions - Hopp-Woods 43-ArgCysGlyArgPro-47 56-AsnAlaSerArgAspLysProMetAlaSerHisLysAla-68 95-CysPheArgArgProValSerArgSerAsnGlnLysSerAlaSerCysSerAsn-112 119-ArgProAlaArgPheIleAla-125 137-ThrProSerProArgLysIle-143 090-1 AMPHI Regions - AMPHI 10-SerGlnSerLeuLysArgPheAspLysHisPheArg-21 56-SerGlnSerGlyAlaValGlyHisIle-64 141-AlaAspPhePheHisAlaValArgGlnAla-150 152-GluGlyPheAspValPheGluGlnCysPheAla-162 164-GlnThrAspGlyLeuThrGln-170 177-ValSerGlyValValGlnThrLeuGlnArg-186 226-LeuHisArgAlaAlaGluArgIleValArgIleGlnAsnLeuHisAlaVal-242 387-IleGluThrValValGlnArgIlePheGlnThrAla-398 404-ProValLysHisLeuThrAspLeuArg-412 425-AsnLeuArgAlaValPheAlaGlnValGlyAsnHisGlyAsnThrArgThrAlaGluSer-444 Antigenic Index - Jameson-Wolf 9-AlaSerGlnSerLeuLysArgPheAspLysHisPheArg-21 29-HisIleLysAlaArgAlaGlyGlyAlaGluGlnHis-40 53-AsnGlyPheSerGlnSerGly-59 73-AlaAspLeuArgArgIleAspThrAsnGlnGlu-83 94-AlaGlnGlyArgGluVal-99 107-GlnAsnHisGluGluArgIleLeuGlnThrGlyAsnArgGlyGlySerArgAlaAspIleArg-127 149-GlnAlaLeuGluGly-153 161-PheAlaArgGlnThrAspGlyLeuThrGlnSerHisGlySerHisAspValSerGly-179 187-AsnValLeuArgAspAsnGln-193 214-PheGlnArgLysProPheTyr-220 228-ArgAlaAlaGluArgIleValArg-235 269-GlnHisArgArgArgSerArgThrGlnAla-278 285-GluAlaGlyLysLeuGln-290 304-ArgLeuGlnAsnArgArgAlaAspIleAlaArgAspAsnGlyIle-318 320-ProAlaLeuAspThrGluIleAlaAspGlnAlaArgTyrArgGly-334 339-AlaGlyAsnArgAsnTyr-344 353 -ValArgGlnGlnPhe-357 379-AspAlaGlyThrGluSerGlnAsnIle-387 398-AlaArgValLysHisGlnProValLysHisLeuThrAspLeuArgHis-413 421-IleIleArgSerAsnLeuArg-427 434-GlyAsnHisGlyAsnThrArgThrAlaGluSerGlyAspGluAspPhePhe-450 Hydrophilic Regions - Hopp-Woods ll-GlnSerLeuLysArgPheAspLysHisPheArg-21 29-HisIleLysAlaArgAlaGlyGlyAlaGluGlnHis-40 73-AlaAspLeuArgArglleAspThrAsnGln-82 94-AlaGlnGlyArgGluVal-99 107-GlnAsnHisGluGluArgIleLeu-114 117-GlyAsnArgGlyGlySerArgAlaAspIleArg-127 163-ArgGlnThrAspGlyLeuThr-169 173-GlySerHisAspVal-177 187-AsnValLeuArgAspAsnGln-193 228-ArgAlaAlaGluArgIleValArg-235 269-GlnHisArgArgArgSerArgThrGln-277 285-GluAlaGlyLysLeuGln-290 305-LeuGlnAsnArgArgAlaAspIleAlaArgAspAsnGlyIle-318 322-LeuAspThrGluIleAlaAspGlnAlaArgTyrArg-333 380-AlaGlyThrGluSerGlnAsnIle-387 398-AlaArgValLysHisGlnPro-404 407-HisLeuThrAspLeuArgHis-413 421-IleIleArgSerAsnLeu-426 437-GlyAsnThrArgThrAlaGluSerGlyAspGluAspPhePhe-450 091-2 AMPHI Regions - AMPHI ll-ProLeuSerAspGlyIleAlaSerCys-19 21-IleThrArgLeuGlnAlaLeuVal-28 33-ValLeuValSerValLeuThrSerLeuAlaLys-43 Antigenic Index - Jameson-Wolf l-LeuSerArgArgCysProProLeuProLysProLeuSerAspGlyIleAla-17 73-LeuArgCysArgLeuProLysProSerAspArgPheAsp-85 105-LeuAspAsnProLeuArgCysArgLeuProIleProSerAspArgPheGly-121 Hydrophilic Regions - Hopp-Woods l-LeuSerArgArgCysProProLeu-8 75-CysArgLeuProLysProSerAspArgPheAsp-85 107-AsnProLeuArgCys-111 115-IleProSerAspArgPhe-120 092 AMPHI Regions - AMPHI 55-GlyMetSerGlyIleAlaGluValLeuHis-64 76-AlaArgAsnAlaAlaThrGluHisLeu-84 95-HisThrAlaGluHisValAsnGly-102 120-ValAlaAlaLeuGlu-124 137-AlaGluLeuMetArgPheArgAsp-144 209-LeuThrProIleMetSerValValThrAsnIleAsp-220 226-ThrTyrGlyHisSerValGluLysLeuHisGlnAlaPheIleAspPheIleHisArg-244 259-HisValArgAlaIleLeuProLysValSerLysProTyr-271 273-ThrTyrGlyLeuAspAspThrAla-280 321-AsnValLeuAsnAlaLeuAlaAlaIle-329 339-ValGluAlaIleGlnLysGly-345 353-GlyArgArgPheGlnLysTyrGlyAspIleLys-363 407-ArgTyrThrArgThrArgAspLeuPheGluAspPheThrLysValLeuAsnThrValAspAlaLeu-42_ 449-LeuAlaArgAlaIleArgValLeuGlyLysLeu-459 464-CysGluAsnValAlaAspLeuProGluMetLeuLeuAsn-476 Antigenic Index - Jameson-Wolf 14-LeuTrpArgAlaAsnGlyGlnProPheLys-23 25-ThrProLeuArgIleGluAsnProProGluArgAsnIleMetMetLysAsnArgVal-43 70-ValSerGlySerAspGlnAlaArgAsnAlaAla-80 lll-AlaValLysLysGluAsnProGluVal-119 140-MetArgPheArgAspGlyIle-146 150-GlyThrHisGlyLysThrThrThr-157 184-GlyThrAsnAlaArgLeuGlyLysGlyGluTyr-194 198-GluAlaAspGluSerAspAla-204 218-AsnIleAspGluAspHisMetAspThrTyrGly-228 230-SerValGluLysLeuHis-235 255-IleAspSerGluHisVal-260 263-IleLeuProLysValSerLysProTyrAla-272 275-GlyLeuAspAspThrAlaAsp-281 286-AspIleGluAsnValGlyAla-292 302-MetLysGlyHisGluGlnGlySerPhe-310 351-GlyValGlyArgArgPheGlnLysTyrGlyAspIleLysLeuProAsnGlyGly-368 374-AspAspTyrGlyHisHisPro-380 393-AlaTyrLeuGluLysArgLeu-399 404-GlnProHisArgTyrThrArgThrArgAspLeuPheGluAspPheThrLys-420 435-AlaAlaGlyGluGluProIleAlaAlaAlaAspSerArgAlaLeuAlaArg-451 466-AsnValAlaAspLeuPro-471 478-LeuGlnAspGlyAspIle-483 488-GlyAlaGlySerIleAsn-493 Hydrophilic Regions - Hopp-Woods 26-ProLeuArgIleGluAsnProProGluArgAsnIleMetMetLysAsnArgVal-43 71-SerGlySerAspGlnAlaArgAsnAlaAla-80 lll-AlaValLysLysGluAsnProGlu-118 140-MetArgPheArgAsp-144 152-HisGlyLysThrThr-156 187-AlaArgLeuGlyLysGlyGlu-193 198-GluAlaAspGluSerAspAla-204 218-AsnIleAspGluAspHisMetAsp-225 230-SerValGluLysLeuHis-235 256-AspSerGluHisVal-260 275-GlyLeuAspAspThrAlaAsp-281 303-LysGlyHisGluGlnGlySer-309 351-GlyValGlyArgArgPheGlnLys-358 360-GlyAspIleLysLeu-364 393-AlaTyrLeuGluLysArgLeu-399 407-ArgTyrThrArgThrArgAspLeuPheGluAspPheThrLys-420 435-AlaAlaGlyGluGluProIleAlaAlaAlaAspSerArgAlaLeuAlaArg-451 466-AsnValAlaAspLeuPro-471 479-GlnAspGlyAspIle-483 093-2 AMPHI Regions - AMPHI 26-ThrAlaIleLeuAsn-30 59-ThrAlaPheAsnIleLeuHisGly-66 159-LysSerValTyrGluGluLeuLysHisLeu-168 196-IleHisIleIleProAlaThrGluPhe-204 254-PheLeuLysAspThr-258 267-IleAsnThrLeuProGlyMetThrSer-275 Antigenic Index - Jameson-Wolf 12-GlyGlyPheSerSerGluArgGluIleSerLeuAspSerGlyThr-26 32-LeuLysSerLysGlyIleAsp-38 41-AlaPheAspProLysGluThrProLeuSerGluLeuLysAlaGlnGly-56 66-GlyThrTyrGlyGluAspGlyAlaVal-74 96-GlyMetAspLysTyrArgCys-102 120-HisAspAspThrAspPheAspAlaValGluGluLyεLeuGly-133 140-ProAlaAlaGluGlySerSer-146 151-LysValLysGlyLysGlyArgLeuLysSerValTyrGluGluLeuLysHisLeuGln-169 176-ArgPheIleGlyGlyGlyGluTyrSer-184 189-AsnGlyLysGlyLeuPro-194 203-GluPheTyrAspTyrGluAlaLysTyrAsnArgAspAspThrIleTyrGlnCysProSerGluAspLeuThr GluAlaGluGluSerLeuMetArg-234 245-GlyAlaGluGlyCysVal-250 253-AspPheLeuLysAspThrAspGly-260 270-LeuProGlyMetThr-274 279-ValProLysSerAlaAla-284 Hydrophilic Regions - Hopp-Woods 15-SerSerGluArgGluIleSerLeu-22 32-LeuLysSerLysGlyIleAsp-38 41-AlaPheAspProLysGluThrProLeuSerGluLeuLysAla-54 68-TyrGlyGluAspGlyAlaVal-74 96-GlyMetAspLysTyrArgCys-102 120-HisAspAspThrAspPheAspAlaValGluGluLysLeuGly-133 140-ProAlaAlaGluGlySerSer-146 151-LysValLysGlyLysGlyArgLeuLysSerValTyrGluGluLeuLysHisLeuGln-169 205-TyrAspTyrGluAlaLysTyrAsnArgAspAspThrIle-217 221-ProSerGluAspLeuThrGluAlaGluGluSerLeuMetArg-234 253-AspPheLeuLysAspThrAspGly-260 094 AMPHI Regions - AMPHI 17-LeuProProIleThrLysValGlySer-25 80-PheSerPheLeuThrAlaVal-86 Antigenic Index - Jameson-Wolf 3-SerProLeuProLysArgAlaLeu-10 24-GlySerSerProAlaAlaProArgMetGluAla-34 50-MetProSerArgLysArgIleAsnSerAlaAsnIleArgAlaArgGlyIleThr-67 Hydrophilic Regions - Hopp-Woods 5-LeuProLysArgAlaLeu-10 28-AlaAlaProArgMetGluAla-34 51-ProSerArgLysArgIleAsn-57 60-AsnIleArgAlaArgGly-65 095-2 AMPHI Regions - AMPHI 9-CysAlaSerAsnLeuPheArgGlnCysGlnGlnArgGlyGlyAspAlaValAsp-26 38-ValLeuGlnAsnValGlnGlnHisPheGlyGlnIleGlyAsnValPheAlaVal-55 86-PheGlyGlnHisGlnArgValAsnGlyIleGluAspPheGlyLysValPheLysGlnIleAlaArg-107 132-GlyArgArgHisPheAspGlyValValSer-141 174-PheLeuAspArgPheAsnArgCysAlaAspPheGlnArgHisAlaAspGlyCysGlnCysValGlnHisVal -197 204-GlnHisAspPheLys-208 236-AspValGlyGlyIleValGlnThrValSerSerIle-247 274-ThrValAspGluIleAspLysArgLeuMetGlnPhePheAspAlaVal-289 313-GlyCysIleArgLeuValGly-319 370-AsnGlyAspAlaValThrGluAlaHisGlnLeuArgGlnHisGlnGlyAla-386 412-AspAspIleArgThrValAsnValPheGlyGlyMet-423 435-MetLeuGlySerGlyIleSerArgLeuIleArgThrGly-447 451-AlaGlnIleValGlnAspPheGlyAspAlaAlaHisAla-463 Antigenic Index - Jameson-Wolf 6-SerGlyGlyCysAlaSerAsnLeu-13 16-GlnCysGlnGlnArgGlyGlyAspAlaValAspAlaSerArgAlaHisIle-32 62-GlnHisAlaAspGlyAlaGlyLysSerAlaGlyIleGlyGlyGlyAsnArgLeuPhe-80 88-GlnHisGlnArgValAsnGlyIleGluAspPheGlyLys-100 112-ValArgLeuGluGlyGluTyr-118 127-AlaCysGlyGlyLysGlyArgArgHisPheAspGly-138 144-ValHisGlnGluArgGlyProAla-151 163-AlaAlaAlaAspAlaPheLysAlaGluGlnAlaPhe-174 176-AspArgPheAsnArgCysAlaAspPheGlnArgHisAlaAspGlyCysGln-192 205-HisAspPheLysArg-209 253-GlyGlnAsnArgAlaAspVal-259 263-AsnThrGlnLysGlyPheAlaVal-270 273-HisThrValAspGluIleAspLysArgLeu-282 300-IleGlyAsnAspGlyHisAsnArgCysGlnValGlnLysGlyCys-314 339-PheAlaAlaAspAsnGluSerArgValLysSerCysArgAlaGluAspGlyGlyGlyGlnAlaGlyGlyArg GlyPheAlaValArgAlaGlyAsnGlyAspAlaValThr-375 378-HisGlnLeuArgGlnHisGlnGlyAlaArgAsnAsnGlyAsn-391 394-LeuGlnArgSerAspAsnPheGly-401 405-PheAspGlyGlyArgGlyAsnAspAspIleArgThr-416 442-ArgLeuIleArgThrGlyAsnPheLys-450 461-AlaHisAlaAspAlaAlaAspThrAspLysMetAspValGlyAsn-475 Hydrophilic Regions - Hopp-Woods 17-CysGlnGlnArgGlyGlyAspAlaValAspAlaSerArgAlaHisIle-32 64-AlaAspGlyAlaGlyLysSerAlaGly-72 93-AsnGlyIleGluAspPheGlyLys-100 112-ValArgLeuGluGlyGluTyr-118 128-CysGlyGlyLysGlyArgArgHisPhe-136 145-HisGlnGluArgGlyPro-150 163-AlaAlaAlaAspAlaPheLysAlaGluGlnAlaPhe-174 182-AlaAspPheGlnArgHisAlaAspGly-190 205-HisAspPheLysArg-209 273-HisThrValAspGluIleAspLysArgLeu-282 300-IleGlyAsnAspGlyHisAsnArgCysGlnVal-310 339-PheAlaAlaAspAsnGluSerArgValLysSerCysArgAlaGluAspGlyGlyGly-357 368-AlaGlyAsnGlyAspAlaValThr-375 378-HisGlnLeuArgGlnHisGlnGlyAlaArgAsnAsnGly-390 395-GlnArgSerAspAsn-399 407-GlyGlyArgGlyAsnAspAspIleArgThr-416 461-AlaHisAlaAspAlaAlaAspThrAspLysMetAspVal-473 096-2 AMPHI Regions - AMPHI 19-GlyIlePheGluGluIleAspAlaHis-27 37-AlaAlaAsnArgGln-41 61-GlyValValAlaVal-65 112-GlnPhePheValAsnAlaPheGln-119 129-AlaTyrAlaAlaAlaPheGlyArg-136 172-AsnGlnPheAlaAla-176 187-AspThrAlaAlaGlyIleGlyAsnAlaGln-196 228-GlnTrpGlyPhePhe-232 Antigenic Index - Jameson-Wolf l-MetAlaArgHisThrGlyGlnGlyVal-9 22-GluGluIleAspAla-26 30-PheArgThrAspCysLeuArgAlaAlaAsn-39 75-GlyCysGlyAsnAspValTyrAla-82 88-ValGlnAspGlyAla-92 97-AlaAlaAspLysThrPheGlyAsn-104 137-ArgPheHisLysHisArgGln-143 157-ValGlnAspGlyGluLeuGlyAsnGlyGlnSerGlnCysLeu-170 181-AlaAspGlyGlyCysGlyAspThr-188 211-ThrValLysAspValGluCysArgLeu-219 Hydrophilic Regions - Hopp-Woods l-MetAlaArgHisThrGlyGln-7 22-GluGluIleAspAla-26 33-AspCysLeuArgAlaAlaAsn-39 97-AlaAlaAspLysThrPheGly-103 137-ArgPheHisLysHisArgGln-143 158-GlnAspGlyGluLeuGlyAsn-164 183-GlyGlyCysGlyAspThr-188 211-ThrValLysAspValGluCysArgLeu-219 097-2 AMPHI Regions - AMPHI 28-AlaGlyLeuThrThrPheLeuThrMetCysTyrIleVal-40 72-MetGlyPheValGly-76 166-AlaThrLeuValGlyLeuGlyAspIleHisGlnProSerAlaLeuLeuAlaLeuPheGly-185 207-ThrIleThrValIleAlaSerLeuMetGlyLeuAsnGluPheHisGlyIleIleGlyGluValProSerIle -230 242-LeuPheThrValSer-246 260-PheAspSerThrGlyThrLeu-266 342-LeuAlaLysSerValProAlaPheAlaThr-351 362-MetLeuArgSerAlaArgAspIle-369 Antigenic Index - Jameson-Wolf 1-MetAspThrSerLysGlnThrLeu-8 13-PheLysLeuLysAlaAsnGlyThrThrValArgThrGluLeu-26 125-LysValArgGluMetLeu-130 260-PheAspSerThrGly-264 277-Va1AspGlyLysLeuProArgLeuLys rg-286 317-SerAlaGlyGlyArgThrGly-323 364-ArgSerAlaArgAspIleAspTrpAspAspMetThrGlu-376 410- euCysArgArgThrLysAspValProPro-419 Hydrophilic Regions - Hopp-Woods l-MetAspThrSerLys-5 16- ysAlaAsnGlyThrThrValArgThrGluLeu-26 125-LysValArgGluMetLeu-130 279-GlyLysLeuProArgLeuLysArg-286 318-AlaGlyGlyArgThr-322 364-ArgSerAlaArgAspIleAspTrpAspAspMetThrGlu-376 410-LeuCySArgArgThrLysAspValPro-418 098-2 AMPHI Regions - AMPHI 29-AlaGluAlaGlyAspGlnPheValGlyAsp-38 110-ValGlyAspPhePheLysLeuAlaPhe-118 120-CysGlnIleGlnAsnValValThrAlaIleAlaGlnIleValAla-134 163-LeuSerSerPheSerHisGly-169 Antigenic Index - Jameson-Wolf 24-ValGlnGluAspAlaAlaGluAlaGlyAspGlnPheVal-36 68-MetGlyMetCysArg-72 78-PheAsnHisThrAspArgGlnAlaAla-86 136-ThrAlaAsnGlyThrGlnSerGlyIleThrGlyArgAsnAlaArgLysArgAsnGlyPhe-155 158-PheGluGlyArgGlyLeuSerSerPheSerHisGlyIle-170 180-ValPheArgArgProMetArgIleCys-188 Hydrophilic Regions - Hopp-Woods 24-ValGlnGluAspAlaAlaGluAlaGlyAsp-33 79-AsnHisThrAspArgGlnAla-85 144-1leThrGlyArgAsnAlaArgLysArgAsnGly-154 158-PheGluGlyArgGly-162 180-ValPheArgArgProMetArg-186 099 (delete this one--mistaken sequence) AMPHI Regions - AMPHI 6-SerMetMetArgLeuProAspI1e-13 47-AlaPheValGluPhePheGlyGluGly-55 102-LysLeuValGluThrTyrAlaLysThr-llO 114-TrpAlaAspAlaLeuLysThrAla-121 135-ThrArgAsnMetAlaGlyProSerAsn-143 154-AlaAlaLysGlyLeuAlaLysProTyrGluGluProSerAspGly-168 178-AlaAlaIleThrSerCysThrAsnThrSerAsnProArgAsnVal-192 251-ThrCysAsnGlyMetSer-256 341-IleAspAlaValValAlaGluTyrValLysProGlnGlnPheArgAspValTyrVal-359 371-ProSerProLeuTyrAspTrpArg-378 381-SerThrTyrIleArg-385 398- rgThrLeuArgGlyMetArgProLeu-406 443-AspPheAsnSerTyrAlaThr-449 468-PheAsnGluMetValLys-473 494-MetArgMetTrpGluAlaIleGluThrTyrMet-504 532-ArgLeuAlaGlyVal-536 539-IleValAlaGluGlyPheGluArgIleHisArgThrAsn-551 575-GlyThrGluThrTyr-579 Antigenic Index - Jameson-Wolf 17-GluLeuAsnGlyLysArgGlnAlaGly-25 38-PheLeuArgLysGluArgValVal-45 53-GlyGluGlyAlaArgSer-58 60-SerIleGlyAspArgAlaThr-66 70-MetThrProGluPhe-74 83-IleAspGluGlnThr-87 94-ThrGlyArgAspAspAlaGlnValLysLeu-103 133-SerValThrArgAsnMetAlaGlyProSerAsnProHis-145 157-GlyLeuAlaLysProTyrGluGluProSerAspGlyGlnMetProAspGly-173 183-CysThrAsnThrSerAsnProArgAsnVal-192 201-AsnAlaAsnArgLeuGlyLeuLysArgLysProTrpVal-213 216-SerPheAlaProGlySerLysValAla-224 235-ProGluMetGluLysLeu-240 251-ThrCysAsnGlyMetSerGlyAlaLeuAspProLysIleGlnLysGluIleIleAspArgAspLeuTyr-27 3 279-SerGlyAsnArgAsnPheAspGlyArgIleHisProTyrAlaLys-293 312-IleArgPheAspIleGluAsnAspVal-320 322-GlyValAlaAspGlyLysGluIleArgLeuLysAsp-333 335-TrpProAlaAspGluGluIleAspAlaVal-344 348-TyrValLysProGlnGlnPheArgAspVal-357 363-AspThrGlyThrAlaGlnLysAlaProSerProLeuTyrAspTrpArgProMetSerThrTyrIleArgArg ProProTyrTrp-390 394-LeuAlaGlyGluArgThrLeuArgGlyMetArg-404 409-LeuProAspAsnIleThrThrAspHisLeuSerProSerAsn-422 438-GlyLeuProGluGluAspPheAsnSerTyrAlaThrHisArgGlyAspHisLeuThr-456 463-AlaAsnProLysLeuPhe-468 471-MetValLysAsnGluAspGlySerValArgGlnGlySerPheAlaArgValGluProGluGlyGluThr-49 3 503-TyrMetAsnArgLysGlnPro-509 516-AlaAspTyrGlyGlnGlySerSerArgAspTrpAlaAlaLysGlyValArg-532 543-GlyPheGluArgIleHisArgThrAsnLeu-552 562-PheLysProAspThrAsnArgHis-569 571-LeuGlnLeuAspGlyThrGluThrTyrAspValValGlyGluArgThrProArgCysAspLeu-591 595-IleHisArgLysAsnGlyGluThrValGlu-604 612-AspThrAlaGluGlu-616 Hydrophilic Regions - Hopp-Woods 18-LeuAsnGlyLysArgGlnAlaGly-25 38-PheLeuArgLysGluArgValVal-45 53-GlyGluGlyAlaArg-57 60-SerIleGlyAspArgAlaThr-66 83-IleAspGluGlnThr-87 94-ThrGlyArgAspAspAlaGlnValLysLeu-103 157-GlyLeuAlaLysProTyrGluGluProSerAspGlyGlnMetProAsp-172 205-LeuGlyLeuLysArgLysProTrpVal-213 235-ProGluMetGluLysLeu-240 259-LeuAspProLysIleGlnLysGluIleIleAspArgAspLeuTyr-273 282-ArgAsnPheAspGlyArgIle-288 312-IleArgPheAspIleGluAsnAspVal-320 324-AlaAspGlyLysGluIleArgLeuLysAsp-333 335-TrpProAlaAspGluGluIleAspAlaVal-344 366-ThrAlaGlnLysAlaPro-371 394-LeuAlaGlyGluArgThrLeuArgGlyMetArg-404 438-GlyLeuProGluGluAspPheAsn-445 450-HisArgGlyAspHis-454 471-MetValLysAsnGluAspGlySerValArg-480 485-AlaArgValGluProGluGlyGluThr-493 503-TyrMetAsnArgLysGlnPro-509 518-TyrGlyGlnGlySerSerArgAspTrpAlaAlaLysGlyValArg-532 543-GlyPheGluArgIleHisArg-549 562-PheLysProAspThrAsnArgHis-569 574-AspGlyThrGluThr-578 580-AspValValGlyGluArgThrProArgCysAsp-590 596-HisArgLysAsnGlyGluThrValGlu-604 612-AspThrAlaGluGlu-616 099-2 AMPHI Regions - AMPHI 30-ProGlySerTyrAspLysLeuPro-37 57-ProThrLeuGlnSerTrpLeuGlyGln-65 91-ThrAlaLeuValAspLeuAlaGlyLeuArgAsp-101 106-LysGlyGlyAspProAlaLysValAsn-114 138-AlaPheArgLysAsn-142 212-AspSerLeuGlyVal-216 234-AlaSerMetMetArgLeuProAspIle-242 276-AlaPheValGluPhePheGlyGluGly-284 331-LysLeuValGluThrTyrAlaLysThr-339 343-TrpAlaAspAlaLeuLysThrAla-350 364-ThrArgAsnMetAlaGlyProSerAsn-372 383-AlaAlaLysGlyLeuAlaLysProTyrGluGluProSerAspGly-397 407-AlaAlaIleThrSerCysThrAsnThrSerAsnProArgAsnVal-421 480-ThrCysAsnGlyMetSer-485 570-IleAspAlaValValAlaGluTyrValLysProGlnGlnPheArgAspValTyrVal-588 600-ProSerProLeuTyrAspTrpArg-607 610-SerThrTyrIleArg-614 627-ArgThrLeuArgGlyMetArgProLeu-635 672-AspPheAsnSerTyrAlaThr-678 697-PheAsnGluMetValLys-702 723-MetArgMetTrpGluAlaIleGluThrTyrMet-733 761-ArgLeuAlaGlyVal-765 768-IleValAlaGluGlyPheGluArgIleHisArgThrAsn-780 804-GlyThrGluThrTyr-808 Antigenic Index - Jameson-Wolf 3-AlaAsnGlnArgTyrArgLysProLeuProGlyThrAspLeuGluTyrTyrAsp-20 22-ArgAlaAlaCysGluAspIleLysProGlySerTyrAspLysLeuProTyr-38 47-LeuValAsnArgAlaAspLysValAspLeuPro-57 67-IleGluGlyLysGlnGluIle-73 97-AlaGlyLeuArgAspAlaIleAlaGluLysGlyGlyAspProAlaLys-112 131-CysGlyGlyTyrAspProAspAlaPheArgLysAsnArgGluIleGluAspArgArgAsnGluAspArgPhe -154 162-ThrAlaPheGluAsn-166 181-AsnLeuGluLysMetSer-186 200-ThrCysValGlyThrAspSerHisThrProHisValAspSer-213 222-GlyGlyLeuGluAlaGluThr-228 246-GluLeuAsnGlyLysArgGlnAlaGly-254 267-PheLeuArgLysGluArgValVal-274 282-GlyGluGlyAlaArgSer-287 289-SerIleGlyAspArgAlaThr-295 299-MetThrProGluPhe-303 312-IleAspGluGlnThr-316 323-ThrGlyArgAspAspAlaGlnValLysLeu-332 362-SerValThrArgAsnMetAlaGlyProSerAsnProHis-374 386-GlyLeuAlaLysProTyrGluGluProSerAspGlyGlnMetProAspGly-402 412-CysThrAsnThrSerAsnProArgAsnVal-421 430-AsnAlaAsnArgLeuGlyLeuLysArgLysProTrpVal-442 445-SerPheAlaProGlySerLysValAla-453 464-ProGluMetGluLysLeu-469 480-ThrCysAsnGlyMetSerGlyAlaLeuAspProLysIleGlnLysGluIleIleAspArgAspLeuTyr-50 2 508-SerGlyAsnArgAsnPheAspGlyArgIleHisProTyrAlaLys-522 541-IleArgPheAspIleGluAsnAspVal-549 551-GlyValAlaAspGlyLysGluIleArgLeuLysAsp-562 564-TrpProAlaAspGluGluIleAspAlaVal-573 577-TyrValLysProGlnGlnPheArgAspVal-586 592-AspThrGlyThrAlaGlnLysAlaProSerProLeuTyrAspTrpArgProMetSerThrTyrIleArgArg ProProTyrTrp-619 623-LeuAlaGlyGluArgThrLeuArgGlyMetArg-633 638-LeuProAspAsnIleThrThrAspHisLeuSerProSerAsn-651 667-GlyLeuProGluGluAspPheAsnSerTyrAlaThrHisArgGlyAspHisLeuThr-685 692-AlaAsnProLysLeuPhe-697 700-MetValLysAsnGluAspGlySerValArgGlnGlySerPheAlaArgValGluProGluGlyGluThr-72 2 732-TyrMetAsnArgLysGlnPro-738 745-AlaAspTyrGlyGlnGlySerSerArgAspTrpAlaAlaLysGlyValArg-761 772-GlyPheGluArgIleHisArgThrAsnLeu-781 791-PheLysProAspThrAsnArgHis-798 800-LeuGlnLeuAspGlyThrGluThrTyrAspValValGlyGluArgThrProArgCysAspLeu-820 824-IleHisArgLysAsnGlyGluThrValGlu-833 841-AspThrAlaGluGlu-845 Hydrophilic Regions - Hopp-Woods 5-GlnArgTyrArgLysProLeuPro-12 22-ArgAlaAlaCysGluAspIleLysProGlySerTyrAsp-34 47-LeuValAsnArgAlaAspLysValAspLeu-56 67-IleGluGlyLysGlnGluIle-73 97-AlaGlyLeuArgAspAlaIleAlaGluLysGlyGlyAspProAlaLys-112 132-GlyGlyTyrAspProAspAlaPheArgLysAsnArgGluIleGluAspArgArgAsnGluAspArgPhe-15 4 181-AsnLeuGluLysMetSer-186 205-AspSerHisThrProHis-210 224-LeuGluAlaGluThr-228 247-LeuAsnGlyLysArgGlnAlaGly-254 267-PheLeuArgLysGluArgValVal-274 282-GlyGluGlyAlaArg-286 289-SerIleGlyAspArgAlaThr-295 312-IleAspGluGlnThr-316 323 -ThrGlyArgAspAspAlaGlnValLysLeu-332 386-GlyLeuAlaLysProTyrGluGluProSerAspGlyGlnMetProAsp-401 434-LeuGlyLeuLysArgLysProTrpVal-442 464-ProGluMetGluLysLeu-469 488-LeuAspProLysIleGlnLysGluIleIleAspArgAspLeuTyr-502 511-ArgAsnPheAspGlyArgIle-517 541-IleArgPheAspIleGluAsnAspVal-549 553-AlaAspGlyLysGluIleArgLeuLysAsp-562 564-TrpProAlaAspGluGluIleAspAlaVal-573 595-ThrAlaGlnLysAlaPro-600 623-LeuAlaGlyGluArgThrLeuArgGlyMetArg-633 667-GlyLeuProGluGluAspPheAsn-674 679-HisArgGlyAspHisLeuThr-685 700-MetValLysAsnGluAspGlySerValArg-709 714-AlaArgValGluProGluGlyGluThr-722 732-TyrMetAsnArgLysGlnPro-738 747-TyrGlyGlnGlySerSerArgAspTrpAlaAlaLysGlyValArg-761 772-GlyPheGluArgIleHisArg-778 791-PheLysProAspThrAsnArgHis-798 803-AspGlyThrGluThr-807 809-AspValValGlyGluArgThrProArgCysAsp-819 824-IleHisArgLysAsnGlyGluThrValGlu-833 841-AspThrAlaGluGlu-845 102 AMPHI Regions - AMPHI 42-ValLeuLeuTyrThrTrpPheSerMetLeu-51 67-GlyAlaSerPheAspThrMetValLysAspLeuLeuGlyArgGlyTrpAsnIleIleAsnGlyIleAla-89 109-ThrAlaLysGlyLeuGlySerAlaAla-117 128-LeuValPhePheGlyIleLeuAlaPheCys-137 144-LeuValAspArgPheThrGlyValLeu-152 155-GlyMetValLeuThr-159 207-AsnValSerSerLeuLeuLysTyrPheLys-216 221-LysValAlaLysSerIle-226 265-ValLeuIleGluThrLeuSerLysPheAlaGlnThrGlyAsnMetAspLysIleLeuSerLeuPheSerTyr MetAla-290 303-PheAspTyrIleAlaAspIlePheLysTrpAsnAsp-314 341-PheValThrAlaIleGlyTyr-347 352-AlaThrValTrpThrGlyIleIlePro-360 374-GlyLysThrTyrLysVal-379 Antigenic Index - Jameson-Wolf l-MetProAsnLysThrProSer-7 64-TyrProHisGlyAla-68 77-LeuLeuGlyArgGly-81 107-AspLeuThrAlaLysGlyLeuGlySerAlaAlaGlyGly-119 169-AlaAspAlaLysProSerVal-175 179-ThrGlnAlaProAlaGlyThr-185 214-TyrPheLysGlyAspAlaProLysValAla-223 246-GlyAsnLeuProArgAsnGluPhe-253 274-AlaGlnThrGlyAsnMetAspLysIle-282 311-LysTrpAsnAspSerIleSerGlyArgThrLysThr-322 364-LeuTyrArgSerArgLysLysPheGlyAlaGlyLysThrTyrLysVal-379 Hydrophilic Regions - Hopp-Woods l-MetProAsnLysThr-5 169-AlaAspAlaLysPro-173 215-PheLysGlyAspAlaProLysValAla-223 248-LeuProArgAsnGluPhe-253 277-GlyAsnMetAspLys-281 316-IleSerGlyArgThrLysThr-322 366-ArgSerArgLysLysPheGlyAla-373 105-2 AMPHI Regions - AMPHI ll-TrpIleGlyLeuGly-15 22-ValThrArgLeuLeuAsp-27 51-LysValTyrGlyAsnThrAlaGluLeu-59 74-AlaAlaValCysAspIleLeuAsnGlyValArgAspGlyLeu-87 97-ThrIleSerProThr-101 110-ValGluAlaAlaGlyGlyGlnPheAlaGluAlaProVal-122 143-AlaValLeuAsnProLeuGlnLysIlePheSer-153 162-PheGlyAspValGlyLysGlySer-169 176-AsnSerLeuLeuGlyIlePheGlyGluAlaTyr-186 203-IleValGluAlaIleGlyXxxSerAla-211 249-LeuGluGlnAlaGlyAsnThrLeuProAlaValGlu-260 263-AlaAlaSerTyrArgLysAlaValGluAla-272 Antigenic Index - Jameson-Wolf 25-LeuLeuAspGlyGlyIleGlu-31 34-ValTyrAsnArgSerProAspLysThrAlaProIleSerAlaLysGlyAlaLysValTyrGlyAsnThr-56 81-AsnGlyValArgAspGlyLeuAla-88 96-SerThrIleSerProThrGluAsnLeuAla-105 121-ProValSerGlySerValGlyProAlaThr-130 139-GlyGlySerGluAla-143 155-ValGlyLysLysThrPheHisPheGlyAspValGlyLysGlySerGly-170 196-PheGlyIleAspThrAspThrI1eVa1-204 211-AlaMetAspSerProMetPheGlnThrLysLysSerLeuTrpAlaAsnArgGluPheProPro-231 237-HisAlaSerLysAspLeuAsnLeuAlaValLysGluLeuGluGlnAlaGlyAsnThrLeuPro-257 264-AlaSerTyrArgLysAlaValGluAlaGlyTyrGlyGluGlnAspValSerGly-281 Hydrophilic Regions - Hopp-Woods 25-LeuLeuAspGlyGlyIle-30 37-ArgSerProAspLysThrAlaProIleSerAlaLysGlyAlaLys-51 81-AsnGlyValArgAspGlyLeuAla-88 164-AspValGlyLysGlySerGly-170 196-PheGly11eAspThrAspThr11e-203 218-GlnThrLysLysSerLeuTrpAla-225 237-HisAlaSerLysAspLeuAsnLeuAlaValLysGluLeuGluGlnAlaGly-253 265-SerTyrArgLysAlaValGlu-271 273-GlyTyrGlyGluGlnAspVal-279 109-2 AMPHI Regions - AMPHI 6-GlyThrTyrArgAspLeuHisArgProAlaSerGlu-17 53-LeuIleProAlaMetAlaGlyThrIleGly-62 69-AlaValAlaAlaAlaPhe-74 145-GlyLeuLeuMetAla-149 156-IleMetAlaLysLeuThrSer-162 177-GlyThrThrGlyGlnValLysLysLeuPheSerTrpAlaGly-190 207-ValMetTyrAlaLeuLeuGluHisTrpLysLysArgTrpLeu-220 222-ValProLeuGlyCysLeuIleAla-229 294-HisGlnValPheGlnLysIle-300 326-ValGlySerIleLeuGly-331 336-ThrSerSerTrpGlyThr-341 471-AlaValGlyMetLeuProGlyIleProProPheLeuGluHisPheLysSerLeu-488 Antigenic Index - Jameson-Wolf l-MetGluLysHisAsnGlyThrTyrArgAspLeuHisArgProAlaSer-16 18-PheAlaThrArgAspGluTyrLeuGlu-26 32-MetGlnProLysArgTrpArgProAsnLeuProPheArgAspTyrArgPheGluTrp-50 78-LeuGlyLeuProAsp-82 109-ProGlyAlaAsnLeuProGlyThrHis-117 160-LeuThrSerAsnGlyVal-165 179-ThrGlyGlnValLysLys-184 259-GluAsnSerGlyTrp-263 301-SerTyrProGluLysThrAspLysVal-309 312-AsnIleAspAspThrMetThr-318 348-IleAlaLysArgProIleProGlyGly-356 398-AlaGlyMetGluMetThrArgLysGlyLysThrThrGln-410 441-GlyCysLysGluArgSerAla-447 Hydrophilic Regions - Hopp-Woods l-MetGluLysHisAsnGlyThrTyrArgAspLeuHisArgProAlaSer-16 18-PheAlaThrArgAspGluTyrLeuGlu-26 35-LysArgTrpArgPro-39 44-ArgAspTyrArgPheGluTrp-50 180-GlyGlnValLysLys-184 301-SerTyrProGluLysThrAspLysVal-309 313-IleAspAspThrMetThr-318 348-IleAlaLysArgProIlePro-354 398-AlaGlyMetGluMetThrArgLysGlyLysThrThrGln-410 441-GlyCysLysGluArgSerAla-447 111-2 AMPHI Regions - AMPHI 6-ArgLeuProAsnPheIleArgVal-13 27-SerGluGlnThrTyrThrValLys-48 58-ProSerProAlaGluIleGlnLysArgIleAspAspAlaLeuLysGluValAsnArgGlnMetSerPheAsnG lnHisThrAlaGlyLeuArgIleSer-102 128-GlyProLeuValAsnLeuTrp-134 151-IleLysGlnAlaAlaSerTyrThrGlyAspTyrAlaSerLeu-174 183-LeuAspLeuSerSerIleAlaLys-190 198-AlaGlyGluTyrLeuValGluIleGlyGly-215 237-AsnIleValGlnLeuSerHisIle-276 314-GluThrGluAlaLeu-318 Antigenic Index - Jameson-Wolf 1-MetProSerGluThrArgLeuProAsnPhe-lO CysSerGluGlnThrAla-31 37-GlnGlyGluThrMetGlyTyr-45 49-TyrLeuSerAsnAsnArgAspLysLeuProSerProAlaGluIleGlnLysArgIleAspAspAlaLeuLysG luValAsnArgGlnMetSerThrTyrGlnProAspSerGluIleSerArgPheAsnGlnHisThrAlaGlyLysPr oLeuArgIleSerSerAspPhe-105 lll-GluAlaValArgLeuAsnArg-117 GlyPheGlyProAspLysSerValThrArgGluProSerProGluGlnIleLysGlnThrGly-159 163-IleIleLeuLysGlnGlyLysAspTyrAlaSerLeuSerLysThrHisProLysAla-181 187-SerPheGlyValAspLysValAlaGlyGluLeuGluLysTyrGly-205 213-IleGlyGlyGluLeuHisGlyLysGlyLysAsnAlaArgGlyGluProTrpArgIleGlyIleGluGlnPro AsnIle-238 240-GlnGlyGlyAsnLeuAsnAsnArgSerLeuAlaThrSerGlyAspTyrArg-262 264-PheHisValAspLysAsnGlyLysArgLeuSerIleAsnProAsnAsnLysArgProIleSerAlaMetThr AlaAspGlyLeuSer-306 314-GluThrGluAlaLeuLysLeuAlaGluArgGluLysLeu-326 332-ValArgAspLysGlyGlyTyrArgMetSerSerGluPheGluLysLeuLeuArg-351 Hydrophilic Regions - Hopp-Woods l-MetProSerGluThrArgLeu-7 26-CysSerGluGlnThrAlaThrMet-41 51-SerAsnAsnArgAspLysLeuProSer-59 61-AlaGluIleGlnLysArgIleAspAspAlaLeuLysGluValAsnArgGlnGlnProAspSerGluIleSerA rg-89 97-LysProLeuArgIleSerSer-103 lll-GluAlaValArgLeuAsnArg-117 137-GlyProAspLysSerValThrArgGluProSerProGluGlnIleLysGln-153 163-IleIleLeuLysGlnGlyLysAspTyrAlaSer-173 175-SerLysThrHisPro-179 196-LysValAlaGlyGluLeuGluLysTyrGly-205 217-LeuHisGlyLysGlyLysAsnAlaArgGlyGluProTrp-229 267-AspLysAsnGlyLysArgLeuSerProAsnAsnLysArgProIle-285 299-AlaMetThrGlyLeuGluThrGluAlaLeuLysLeuAlaGluArgGluLysLeu-326 332-ValArgAspLysGlyGlyTyr-338 344-SerGluPheGluLysLeuLeuArg-351 117-1 AMPHI Regions - AMPHI 6-ProIleGlnAspThrGlnSerAla-13 15-LeuGlnGluLeuArgGluTrpPheAspSerTyrCysAlaThrPro-55 57-GlyGluProLeuProAspHisHisGluLeuAspLeuLeu-77 79-AspAlaValAlaAlaThrLeuLeuAlaAspIleGlyArgTyr-92 94-ProAspTrpLeuValSerCysAsnSerThrValAlaGluLeuValLysGlyValAspGluValGlnLysLeuT hrHisPheAlaArgValAspSerLeuGlnAlaGluThrLysMetLeuLeuAlaMet-150 170-PheLeuSerAsnAlaProAspSerProGluLysAspIlePhe-191 216-LysProGluLysTyrArgArgLeuGluTyrIleGluAsnPheLeuAsnIleLeuArg-246 260-GlyArgProLysHisIleTyrSerIleTyrLys-270 282-LeuPheAspIleArg-286 290-IleLeuValAspThrValProGluCysTyrThrThrLeuGlyIleValHisSerLeuTrpGlnProIlePro GlyGluPheAspAspTyrIleAla-321 327-GlyTyrLysSerLeuHisThr-333 351-AspMetHisGlnPheAsnGluPheGlyValAla-361 385-GlnLeuLeuAspTrp-389 412-AspThrHisGlyLysValHisSerSerIleGlyAspArgLeuGluAsn-465 485-TyrGluLysAlaIleGlyLysIleArgAlaTyrGlnGlnAsnAlaAsp-508 510-ValArgGluGlnLeuAlaLysLeuGlnGluLeuAlaGluGlyTyrLysLysProGluAspLeuTyrThrAsn ArgAlaIleGlnLysAlaCysGlyThrLeuAsnGluProPro-571 585-LysIleLysLysGlyGlyMetThrThrLeuAlaLysCysCysLysProAlaAspAspIleIleGly-620 636-ProSerPheGlnHisLeuAlaGluHisAlaProGluLysValLeuAspAlaLeuGlnGlu-659 679-ArgAspValSerAspAla-684 714-GlnValAsnAspLeuProArgValLeuAlaSerLeuGlyAspValLysGlyValLeuSerValThrArg-73 6 Antigenic Index - Jameson-Wolf 5-SerProIleGlnAspThrGlnSerAlaThr-14 16-GlnGluLeuArgGluTrpPheAspSerTyrCysAlaAlaLeuProAspAsnAspLysAsnLeuHisTyrProA la-50 52-AlaAlaThrProTyrGlyGluProLeuProAspHisPhe-64 72-HisAspLeuLeuPro-78 88-AspIleGlyArgTyrValProAspTrp-96 100-ValSerGluArgCysAsnSerThrVal-108 110-GluLeuValLysGlyValAspGluValGlnLysHis-123 125-AlaArgValAspSerLeuAlaThrProGluGluArgAlaGlnGlnAlaGluThrMetArg-144 162-AlaMet rgThrArgThr-167 173-AsnAlaProAspSerProGluLysArgAlaValAlaLysGluThrLeu-188 209-AspLeuGlyPheArgHisGlnLysProGluLysTyrArgGluLeuAspGluLysArgThrGluArgLeuGlu Tyr-237 245-LeuArgGlyGluLeuLysLysTyrAsnValAlaGlyArgProLysHisLysMetValLysLysLysLeuSer Phe-279 283-PheArgAlaThrValProGluCysTyr-299 311-ProIleProGlyGluPheAspAspTyrIleAlaAsnProLysGlyAsnGlyTyrLysSerIleValGlyPro GluAspLysGlyValGluValGlnIleArgThr-349 356-AsnGlyTrpArgTyrLysGluGlyGlyLysGlyAspSerAlaTyrGluGlnLys-379 387-LeuAspTrpArgGluAsnMetAlaGluSerGlyLysGluAspLeuAlaAla-403 418-ThrProHisGlyLysProThrGly-429 440-HisSerSerIleGlyAspArgCysArgGlyAlaLysValGluGlyThrProLeuGluAsnGlyGlnArgVal GluIlelleThrAlaLysGluGlyHisProSerValAsnGlyTrpValLysSerAsnLysAlalleGlyLysAla- 500 502-IleArgGlnGlnAsnAlaAspThrValArgGluGluGlyArgValGlnLeuAspLysGlnLeuAla-523 525-LeuThrProLysProAsnLeuGlnGluLeuAlaGlu-536 538-LeuGlyTyrLysLysProGluAspLeuGlyGlnGlyGluIleSerAsnArgAlaIleGlnLysAlaCysGly ThrLeuAsnGluProProProValPro-574 582-LysGlnSerLysIleLysLysGlyGlyLysAsnGlyVal-594 596-IleAspGlyGluAspGlyLeu-602 608-LysCysCysLysProAlaProProAspAspIleIleValThrArgGluArgGlyIleSerValHisArgLys ThrCysProSerPhe-638 644-HisAlaProGluLysValLeuAspGlnIleGluIleArgAlaGlnAspArgSerGlyLeuLeuArgAspVal SerAspAlaLeuAlaArgHisLysLeu-690 696-GlnThrGlnSerArgAspLeuGluAlaSerMet-706 710-LeuGluValLysGlnValAsnAspLeuProArg-720 726-GlyAspValLysGly-730 Hydrophilic Regions - Hopp-Woods 8-GlnAspThrGlnSer-12 16-GlnGluLeuArgGluTrpPhe-22 30-ProAspAsnAspLysAsnLeu-36 48-TyrProAlaProLeuProHisAspLeuLeuPro-78 100-ValSerGluArgCysAsnSerThrGluLeuValLysGlyValAspGluValGlnLysHis-123 125-AlaArgValAspSer-129 131-AlaThrProGluGluArgAlaGlnGlnAlaGluThrMetArg-144 162-AlaMetArgThrArgThrAlaProAspSerProGluLysArgAlaValAlaLysGluThrLeu-188 209-AspLeuGlyPheArgHisGlnLysProGluLysTyrArgGluLeuAspGluLysArgThrGluArgLeuGlu Tyr-237 245-LeuArgGlyGluLeuLysLysTyr-252 258-ValAlaGlyArgLysHisLysMetValLysLysLysLeuSerPhe-279 283-PheArgAlaThrValPro-296 314-GlyGluPheAspAsp-318 323-ProLysGlyAsnGly-327 337-GlyProGluAspLysGlyValGluValGlnlleArgThr-349 351-AspGlnArgTyrLysGluGlyGlyLysGlyAspSerAlaTyrGluGlnLeuAspTrpArgGluAsnMetAla GluSerGlyLysGluAspLeuAlaAla-403 405-PheLysLeuPheIleGlyAspArgCysArgGlyAlaLysValGluGlyLeuGluAsnGlyGlnArgValGlu IleIleThrAlaLysGluGlyHisPro-479 489-ValLysSerAsnLysAlaIleGlyLysAla-500 502-IleGlnAsnAlaAspThrValArgGluGluGlyArgValGlnLeuAspLysGlnLeuAla-523 538-LeuGlyTyrLysLysProGluAspLeuGly-551 553-GlyGluIleSerAsn-557 582-LysGlnSerLysIleLysLysGlyGlyLysVal-594 596-IleAspGlyGluAspGlyLeu-602 608-LysCysCysLysProAlaProProAspAsp-617 623-ThrArgGluArgGlyIleSerValHisArgLysThrCysHisAlaProGluLysValLeu-650 658-GlnIleGluIleArgAlaGlnAspArgSerGlyLeuLeuArgAspValSerAspAlaLeuAlaArgHisLys LeuThrGlnSerArgAspLeuGluAlaSerMet-706 710-LeuGluValLysGlnValAsnAspLeuProArg-720 726-GlyAspValLysGly-730 118-2 AMPHI Regions - AMPHI ll-ArgArgAsnIleGlyLysTrpTyrAsp-31 61-ProArgTyrIleGlyThrIleIleAspPheLeuMetValProAsn-79 102-GluArgLeuLysThrMetLeuArg-109 Antigenic Index - Jameson-Wolf 8-LysAsnPheArgArgAsnIleThrCysPheGluGlyTyrAspGluAsnSerPhe-25 27-GlyLysTrpTyrAspAspGlyValTrpAspAspGluGluTyrTrpLysLeuGluAsnAspLeuIleGluValA rgLysLysTyrProTyrProMetAspIle-60 93-AspSerValGlyIleAsnGluArgTyrGluArgLeuLysThr-106 112-PheThrGluLysAspI1eValAspTyrTyrAsnLysLys-128 Hydrophilic Regions - Hopp-Woods 8-LysAsnPheArgArgAsnlleThr-15 33-GlyValTrpAspAspGluGluTyrTrpLysLeuGluAsnAspLeuIleGluValArgLysLysTyrProTyrA spIle-60 95-ValGlyIleAsnGluArgTyrGluArgLeuLysThr-106 112-PheThrGluLysAspIleVal-118 120-2 AMPHI Regions - AMPHI 6-LysAsnIlePheSerAla-ll 49-SerGlyAsnAlaTyrLysIleValSerThrIleLys-60 77-AsnThrLeuHisProThrTyrTyrArgAspI1eArgArg-89 142-IleThrAsnGlyLysLysLeuTyrSerValGlyGlyLeuAsnLysAlaGly-158 189-ProSerLeuAsnAsnIleProAla-196 Antigenic Index - Jameson-Wolf 3-LysThrPheLys-6 35-SerGlySerTyrGly-39 45-ThrPheGluArgSerGlyAsnAlaTyrLys-54 68-PheGluSerGlyGlyThrValVal-75 85-ArgAspIleArgArgGlyLysLeuTyrAlaGlu-95 97-LysPheAlaAspGlySerValThrTyrGlyLysAlaGlyGluSerLysThrGluGlnSerProLysAla-119 131-AlaAsnAspAlaLysLeuProProGlyLeuLysIleThrAsnGlyLysLysLeuTyrSer-150 153-GlyLeuAsnLysAlaGlyThrGlyLysTyrSerIleGlyGlyValGluThrGluValValLysTyrArgVal ArgArgGlyAspAspAlaVal-183 199-GlyTyrThrAspAspGlyLysThrTyr-207 218-GlyGlnAlaAlaLysPro-223 Hydrophilic Regions - Hopp-Woods 45-ThrPheGluArgSerGlyAsn-51 85-ArgAspIleArgArgGlyLysLeuTyrAla-94 107-LysAlaGlyGluSerLysThrGluGlnSerProLysAla-119 131-AlaAsnAspAlaLysLeu-136 143-ThrAsnGlyLysLysLeuTyr-149 155-AsnLysAlaGlyThrGly-160 167-ValGluThrGluValValLysTyrArgValArgArgGlyAspAspAla-182 200-TyrThrAspAspGlyLysThrTyr-207 219-GlnAlaAlaLysPro-223 121-1 AMPHI Regions - AMPHI 42-ProGlyArgLeuArgArg-47 68-GlnGluLeuSerArgLeuTyrAlaGlnThr-77 101-ThrValArgHisAlaPro-106 148-ProAlaPheHisGlu-152 165-LeuAsnIleGlyGlyIleAlaAsnIle-173 189-ProGlyAsnMetLeuMetAspAlaTrpThr-198 216-GlyAsnIleLeuProGlnLeuLeuAspArgLeuLeu-227 237-ProLysSerThrGly-241 251-GluThrTyrLeuAsp-255 262-AspValLeuArgThrLeuSerArgPheThrAlaGlnThrValCysAspAlaValSerHis-281 303-AlaAspLeuAlaGluCysPhe-309 341-IleAsnArgIleProGlySerPro-348 Antigenic Index - Jameson-Wolf 13-ThrSerMetAspGlyAlaAsp-19 23-IleArgMetAspGlyGlyLysTrpLeuGly-32 40-ProTyrProGlyArgLeuArgArgGlnLeuLeuAspLeuGlnAspThrGlyAlaAspGluLeuHisArgSerA rgIleLeuSer-67 86-AsnLeuAlaProSerAspIleThrAla-94 97-CysHisGlyGlnThrValArgHisAlaProGluHisGlyTyrSer-lll 119-LeuLeuAlaGluArgThrArg-125 128-ThrValGlyAspPheArgSerArgAspLeuAlaAlaGlyGlyGlnGly-143 154-LeuPheArgAspAsnArgGluThrArgAla-163 177-ProProAspAlaPro-181 184-GlyPheAspThrGlyProGlyAsn-191 205-ProTyrAspLysAsnGlyAlaLysAlaAlaGlnGlyAsn-217 235-ProHisProLysSerThrGlyArgGlu-243 253-TyrLeuAspGlyGlyGluAsnArgTyrAspValLeuArgThrLeuSerArg-269 283-AlaAlaAspAlaArgGln-288 293-GlyGlyGlyIleArgAsnProValLeu-301 321-LeuAsnLeuAspProGlnTrp-327 344-IleProGlySerProHisLysAlaThrGlyAlaSerLysProCysIle-359 Hydrophilic Regions - Hopp-Woods 13-ThrSerMetAspGlyAlaAsp-19 43-GlyArgLeuArgArgGlnLeuLeuAspLeuGlnAspThrGlyAlaAspGluLeuHisArgSerArgIleLeuS er-67 101-ThrValArgHisAlaPro-106 119-LeuLeuAlaGluArgThrArg-125 131-AspPheArgSerArgAspLeuAlaAla-139 154-LeuPheArgAspAsnArgGluThrArgAla-163 206-TyrAspLysAsnGlyAlaLysAlaAlaGln-215 236-HisProLysSerThrGlyArgGlu-243 254-LeuAspGlyGlyGluAsnArgTyrAspVal-263 283-AlaAlaAspAlaArgGln-288 345-ProGlySerProHisLysAlaThrGlyAlaSer-355 122-1 AMPHI Regions - AMPHI 6-AsnIleHisLysThrPhe-ll 42-ThrPheLeuArgCysLeuAsnAlaLeuGluMetProGlu-54 102-LeuGluAsnValMetGlu-107 126-LysLeuLeuGluLys-130 176-ProGluLeuValGlnAspValLeuAspThrMetLysGluLeuAla-190 227-ProGlnAspLeuPheAspHisPro-234 Antigenic Index - Jameson-Wolf 5-ArgAsnIleHisLysThrPheGlyGluAsnThrIle-16 23-AspValCysLysGlyGln-28 34-GlyProSerGlySerGlyLysThrThr-42 51-GluMetProGluAspGlyGlnIleGluPheAspAsnGluArgProLeuLysIleAspPheSerLysLysProS erLysHisAspIle-79 81-AlaLeuArgArgLysSerGlyMet-88 96-PheProHisLysThrAlaLeu-102 114-GlyLysProAlaAlaGlnAlaArgGluGluAlaLeuLysLeuLeuGlu-129 131-ValGlyLeuGlyAspLysValAspLeuTyr-140 142-TyrGlnLeuSerGlyGlyGlnGlnGlnArgValGlyIle-154 168-AspGluProThrSerAlaLeuAspProGluLeuVal-179 182-ValLeuAspThrMetLysGluLeuAlaGlnGluGly-193 216-MetAspGlyGlyVal-220 222-ValGluGlnGlySerProGlnAspLeuPheAspHisProLysHisGluArgThrArgArgPheLeuSer-24 4 246-IleGlnSerThrLysIle-251 Hydrophilic Regions - Hopp-Woods 51-GluMetProGluAspGlyGlnIleGluPheAspAsnGluArgProLeuLysIleAspPheSerLysLysProS erLysHisAsp-78 81-AlaLeuArgArgLysSerGly-87 114-GlyLysProAlaAlaGlnAlaArgGluGluAlaLeuLysLeuLeuGlu-129 131-ValGlyLeuGlyAspLysValAsp-138 168-AspGluProThrSerAlaLeuAspProGluLeuVal-179 182-ValLeuAspThrMetLysGluLeuAlaGln-191 229-AspLeuPheAspHisProLysHisGluArgThrArgArgPheLeu-243 126-1 AMPHI Regions - AMPHI 73-GlyCysGlnSerValGlnGluAla-80 112-PheGlnLeuValGluAla-117 143-LeuAspAlaGlyCysGln-148 150-LeuMetProTrpAlaAlaProIleGlyThrGlyLeuGlyAlaVal-164 213-SerGlyAspProValAsnMetAlaArgAlaPhe-223 Antigenic Index - Jameson-Wolf 7-GluThrPheProSerArgLeu-13 24-GluIleLeuLysGlnSerIle-30 41-SerLeuArgArgAlaGlySerGlyGlyGluAlaHisGlyGlnGlyPhe-56 85-GlnMetAlaArgGluValPheGlu-92 99-GluLeuIleGlyAspAspAspThrLeuGln-108 121-LeuIleLysAspGlyPheLysValLeu-129 141-ArgLeuLeuAspAlaGlyCys-147 171-ValLeuArgGluArgLeuProAspThrProLeu-181 209-AlaValSerArgSerGlyAspProValAsn-218 228-GluSerGlyArgLeuAlaPhe-234 237-GlyProValGluAlaArgAspLysAlaGlnAlaSerThrProThrVal-252 Hydrophilic Regions - Hopp-Woods 41-SerLeuArgArgAlaGlySerGlyGlyGluAlaHis-52 85-GlnMetAlaArgGluValPheGlu-92 100-LeulleGlyAspAspAspThrLeuGln-108 171-ValLeuArgGluArgLeuProAsp-178 210-ValSerArgSerGlyAspPro-216 228-GluSerGlyArgLeuAlaPhe-234 237-GlyProValGluAlaArgAspLysAlaGlnAla-247 127 AMPHI Regions - AMPHI 6-MetLeuAspThrTrpLeuGlyAla-13 20-AlaValGluSerValAlaAla-26 119-ValGlyAspTyrIleGluIle-125 135-IleAsnLeuLeuAsnThrLeuMet-142 147-ProAsnProLeuValGlyGlnLeuAla-155 206-LeuGluProLeuCysAlaPro-212 214-IleProAlaIleGlnArgXxxLeuGluAsnValGln-225 250-ArgIleIleValArgPheAlaSerProVal-259 268-AlaValMetAspGluPheLeuArgVal-276 Antigenic Index - Jameson-Wolf 16-IleArgAlaGluAlaValGlu-22 41-HisPheLysArgHisProAspPheGlyIleGluSerLysArgArgPheLeuVal-58 112-SerAlaThrGlnGlnTyrSerVal-119 126-AsnGlyLeuArgGlyArgValValAsp-134 169-HisProValArgArgAspAsnIleLeu-177 193-LeuAspSerAspGluAlaValCysArg-201 234-AlaAlaArgProArgValThrArgValProTyrAspAspLysAlaTyr-249 257-SerProValSerLysArgLeuGluIle-265 282-AsnHisProAlaGlySerGluThrLeu-290 Hydrophilic Regions - Hopp-Woods 16-IleArgAlaGluAlaValGlu-22 42-PheLysArgHisProAspPheGlyIleGluSerLysArgArgPheLeuVal-58 126-AsnGlyLeuArgGlyArgValVal-133 170-ProValArgArgAspAsnlleLeu-177 193-LeuAspSerAspGluAlaValCysArg-201 235-AlaArgProArgValThrArgValProTyrAspAspLysAlaTyr-249 259-ValSerLysArgLeuGluIle-265 285-AlaGlySerGluThrLeu-290 128-1 AMPHI Regions - AMPHI 43-AlaGlnThrHisThrGlyTrpAlaAsnThrValGluProLeuThrGlyIleThrGluArgValGlyArgIleT rpGlyValValSerHisLeuAsnSerValAlaAspThrProGluLeu-82 85-ValTyrAsnGluLeuMetProGluIle-93 102-GlnAspIleGluLeuTyrAsnArgPheLysThrIleLysAsnSerProGluPhe-119 166-PheSerGlnAsnValLeuAspAlaThrAsp-175 189-GlyIleProGluAspAla-194 218-HisTyrLeuAlaVal-222 245-GluLeuSerAspAspGlyLysPheAspAsnThrAlaAsnIleAspArgThrLeuAlaAsnAlaLeuGlnThr AlaLysLeuLeuGlyPheLysAsnTyrAlaGlu-279 286-MetAlaAspThrProGluGlnValLeuAsnPheLeuHisAspLeuAlaArgArgAla-304 313-AlaGluValLysAlaPheAlaArg-320 359-GlyLysValLeuAsnGlyLeuPheAlaGlnIleLysLysLeuTyrGly-374 472-LeuHisHisLeuLeuThrGlnValAspGluLeu-482 496-GluLeuProSerGlnPhe-501 565-GlyArgLeuLysAsnTrpGlnGlnValLeuAspSerVal-577 610-SerTyrAlaTrpAlaGlu-615 623-AlaAlaPheGluGluSerAspAsp-630 636-LysArgPheTrpGluIleLeuAla-644 651-AlaAlaGluSerPheLysAlaPheArg-659 Antigenic Index - Jameson-Wolf 9-LeuGlyGluGluProArgPheAspGlnIleLysThrGluAspIleLysProAlaLeu-27 32-AlaGluAlaArgGluGlnlleAla-39 43-AlaGlnThrHisThrGlyTrp-49 51-AsnThrValGluProLeuThrGlyIleThrGluArgValGlyArgIleTrp-67 75-SerValAlaAspThrProGluLeu-82 100-IleGlyGlnAspIleGluLeuTyrAsnArgPheLysThrIleLysAsnSerProGluPheAspThrLeuSer ProAlaGlnLysThrLysLeuAsnHisAspLeuArgAsp-136 138-ValLeuSerGlyAlaGluLeuProProGluGlnGlnAlaGluLeuAlaLysLeuGlnThrGluGlyAlaGln Leu-162 165-LysPheSerGlnAsnVal-170 172-AspAlaThrAspAla-176 190-IleProGluAspAla-194 202-AlaGlnSerGluSerLysThrGlyTyrLysIle-212 226-AlaAspAsnArgGluLeuArgGluGlnIle-235 240-ValThrArgAlaSerGluLeuSerAspAspGlyLysPheAspAsnThrAlaAsnIleAspArgThrLeu-26 2 285-LysMetAlaAspThrProGluGln-292 300-LeuAlaArgArgAlaLysProTyrAlaGluLysAspLeuAlaGlu-314 316-LysAlaPheAlaArgGluSerLeuAsn-324 335-TyrAlaSerGluLysLeuArgGluAlaLysTyrAlaPheSerGluThrGluValLysLys-354 376-GlyPheThrGluLysThrVal-382 387-LysAspValArgTyrPheGluLeuGlnGlnAsnGlyGluThrIle-401 409-TyrAlaArgGluGlyLysArgGlyGlyAla-418 420-MetAsnAspTyrLysGlyArgArgArgPheSerAspGlyThrLeu-434 447-ProProValGlyGlyArgGluAlaArgLeuSerHisAspGlu-460 478-GlnValAspGluLeuGlyVal-484 496-GluLeuProSerGln-500 516-SerAlaHisGluGluThrGlyVal-523 560-SerGluAspAspGluGlyArgLeuLysAsn-569 575-AspSerValArgLysLysValAla-582 586-ProProGluTyrAsnArg-591 605-SerAlaGlyTyrTyrSerTyr-611 625-PheGluGluSerAspAspValAlaAlaThrGlyLysArgPheTrp-639 646-GlyGlySerArgSerAlaAlaGluSerPheLysAlaPheArgGlyArgGluProSerIle-665 669-LeuArgHisSerGlyPheAspAsnAlaVal-678 Hydrophilic Regions - Hopp-Woods 9-LeuGlyGluGluProArgPheAspGlnIleLysThrGluAspIleLysPro-25 32-AlaGluAlaArgGluGlnIleAla-39 59-IleThrGluArgValGly-64 77-AlaAspThrProGluLeu-82 lOO-IleGlyGlnAspIleGluLeu-106 lll-LysThrIleLysAsnSerProGluPheAspThr-121 123-SerProAlaGlnLysThrLysLeuAsnHisAspLeuArgAsp-136 143-GluLeuProProGluGlnGlnAlaGluLeuAlaLysLeuGlnThrGluGlyAlaGlnLeu-162 190-IleProGluAspAla-194 202-AlaGlnSerGluSerLysThrGlyTyr-210 226-AlaAspAsnArgGluLeuArgGluGlnIle-235 242-ArgAlaSerGluLeuSerAspAspGlyLysPheAspAsn-254 256-AlaAsnlleAspArgThrLeu-262 285-LysMetAlaAspThrProGlu-291 300-LeuAlaArgArgAlaLysProTyrAlaGluLysAspLeuAlaGlu-314 316-LysAlaPheAlaArgGluSerLeuAsn-324 335-TyrAlaSerGluLysLeuArgGluAlaLysTyrAlaPheSerGluThrGluValLysLys-354 377-PheThrGluLysThr-381 387-LysAspValArgTyr-391 396-GlnAsnGlyGluThr-400 409-TyrAlaArgGluGlyLysArgGlyGly-417 423-TyrLysGlyArgArgArgPheSerAsp-431 449-ValGlyGlyArgGluAlaArgLeuSerHisAspGlu-460 478-GlnValAspGluLeuGly-483 516-SerAlaHisGluGluThrGly-522 560-SerGluAspAspGluGlyArgLeuLysAsn-569 575-AspSerValArgLysLysValAla-582 625-PheGluGluSerAspAspValAlaAlaThrGly-635 647-GlySerArgSerAlaAlaGluSerPheLysAlaPheArgGlyArgGluProSerIle-665 130-2 AMPHI Regions - AMPHI 16-ThrLeuValSerGlyIle-21 36-GlySerGlySerPheGly-41 56-GlnProValGlyGlnLeu-61 91-AsnValProAsnAlaPro-96 110-GlnGlyPheAspThrLeuPheGlnHisAlaLeuAsnGlyPheAsnAlaMet-126 171-ThrAlaSerAlaPro-175 204-PheGluAlaThrCysGln-209 211-CysHisGlyGlySerIleProGlyIlePro-220 234-LysGlyLysGluThr-238 245-GluGlyPheAsnAlaMet-250 Antigenic Index - Jameson-Wolf l-MetLysGlnLeuArgAspAsnLysAlaGlnGlySer-12 35-AlaGlySerGlySerPheGlyAspValAspAlaThrThrGluAlaAlaThrGlnThrArgIleGlnProValG ly-59 63-MetGlyAspGlyIleProValGlyGluArgGlnGlyGlu-75 87-AlaAlaAspSerAsnValProAsnAlaProLysLeuGluHisAsnGlyAspTrpAla-105 108-IleAlaGlnGlyPhe-112 126-MetProAlaLysGlyGlyAla-132 134-AspLeuThrAspGlnGluLeuLysArg-142 148-AlaAsnLysSerGlyGlySerPheProAsnProAspGluAlaAlaProAlaAspAsnAlaAlaSerGlyThr AlaSerAlaProAlaAspSerAlaAlaProAlaGluAlaLysAlaGluAspLysGlyAlaAla-192 197-GlyValAspGlyLysLysValPheGlu-205 221-GlyIleGlyLysLysAspAspTrpAlaProArgIleLysLysGlyLysGluThrLeuHis-240 251-ProAlaLysGlyGlyAsnAlaGlyLeuSerAspAspGluValLysAla-266 274-GlnSerGlyAlaLys-278 Hydrophilic Regions - Hopp-Woods 1-MetLysGlnLeuArgAspAsnLysAlaGlnGly-ll 41-GlyAspValAspAlaThrThrGluAlaAlaThr-51 68-ProValGlyGluArgGlnGlyGlu-75 87-AlaAlaAspSerAsnVal-92 96-ProLysLeuGluHisAsnGly-102 127-ProAlaLysGlyGlyAla-132 134-AspLeuThrAspGlnGluLeuLysArg-142 156-ProAsnProAspGluAlaAlaProAlaAspAsnAlaAla-168 174-AlaProAlaAspSerAlaAlaProAlaGluAlaLysAlaGluAspLysGlyAlaAla-192 198-ValAspGlyLysLysValPheGlu-205 222-IleGlyLysLysAspAspTrpAlaProArgIleLysLysGlyLysGluThrLeuHis-240 251-ProAlaLysGlyGlyAsn-256 258-GlyLeuSerAspAspGluValLysAla-266 132-2 AMPHI Regions - AMPHI 13-IleIleSerAlaLeuAlaVal-19 70-AlaThrCysMetAlaMetVal-76 92-ValGlnGlnThrGlnGlnAlaProLysProValSerAsnThr-105 Antigenic Index - Jameson-Wolf 26-GlnHisGlyLysGlyAlaAspAla-33 38-GlySerGlySerGlySerAla-44 81-HisThrThrLysHisGlyLeuAspPhe-89 91-AsnValGlnGlnThrGlnGlnAlaProLysProValSerAsnThrGluProSerAlaProValProGlnGlnG lnLys-116 Hydrophilic Regions - Hopp-Woods 28-GlyLysGlyAlaAspAla-33 97-GlnAlaProLysProValSerAsnThrGluProSerAla-109 134 AMPHI Regions - AMPHI 39-IleGlnSerAlaGlyThrVal-45 47-GlyLysLysThrGly-51 58-TrpMetGluIleGluLysGlnArg-65 83-ValAsnLeuLeuAspThrProGlyHis-91 97-AspThrTyrArgValLeuThrAlaVal-105 114-AlaAlaGlyValGlu-119 123-IleLysLeuLeuAsnValCysArg-130 142-LysTyrAspArgGluVal-147 149-AspSerLeuGluLeuLeuAspGluValGluAsnIleLeuLys-162 176-LysAsnPheLysGlyValTyrHisIleLeu-185 201-HisGluPheAspIleIleLysGlyIleAspAsn-211 254-PheGlySerAlaIle-258 265-GluIleLeuAsnSerLeuIleAspTrpAlaPro-275 322-LysPheGluArgGlyMetLys-328 361-AspIleIleGlyIleProAsnHis-368 395-LeuPheArgSerValArgIleLys-402 404-ProLeuLysIleLysGln-409 411-GlnLysGlyLeuGlnGlnLeuGlyGlu-419 423-ValGlnValPheLysProMetSer-430 449-Ser rgLeuAlaAsnGluTyr-455 481-AlaGluPheGluLysAlaAsn-487 515-ArgTrpProAspIle-519 Antigenic Index - Jameson-Wolf 4-GluIleLeuAspGlnValArgArgArgArgThrPhe-15 19-SerHisProAspAlaGlyLysThrThrLeuThr-29 43-GlyThrValLysGlyLysLysThrGlyLysPheAlaThr-55 57-AspTrpMetGluIleGluLysGlnArgGly-66 76-PheAspTyrLysAspHisThrVal-83 85-LeuLeuAspThrProGlyHisGlnAspPheSerGluAspThrTyrArg-100 113-AspAlaAlaLysGlyValGlu-119 129-CysArgLeuArgAspThrPro-135 140-MetAsnLysTyrAspArgGluValArgAspSerLeuGluLeuLeuAspGluValGluAsn-159 173-GlyMetGlyLysAsnPheLys-179 194-AlaGlyGlyGluArgLeuProHis-201 207-LysGlyIleAspAsnProGluLeuGluGlnArgPheProLeu-220 223-GlnGlnLeuArgAspGluIleGluLeu-231 235-AlaSerAsnGluPheAsnLeu-241 275-ProAlaProLysProArgAspAlaThrValArgMetValGluProAspGluProLysPhe-294 302-GlnAlaAsnMetAspProLysHisArgAspArgIleAla-314 317-ArgValCysSerGlyLysPheGluArgGlyMetLysMetLysHisLeuArgIleAsnArgGluIleAla-33 9 348-SerHisAspArgGluLeuValGlu-355 365-IleProAsnHisGly-369 373-IleGlyAspSerPheSerGluGlyGluGln-382 399-ValArgIleLysAsnProLeuLysIleLysGlnLeuGlnLysGlyLeuGlnGlnLeuGlyGluGluGlyAla -422 450-ArgLeuAlaAsnGluTyrGlyVal-457 459-AlaValPheAspSer-463 473-SerCysAspAspLysLysLysLeuAlaGluPheGluLysAlaAsnAla-488 503-AlaProAsnArgValAsnLeu-509 511-LeuThrGlnGluArgTrpProAspIleVal-520 523-GluThrArgGluHisSerVal-529 Hydrophilic Regions - Hopp-Woods 4-GluIleLeuAspGlnValArgArgArgArgThr-14 21-ProAspAlaGlyLys-25 43-GlyThrValLysGlyLysLysThrGlyLys-52 59-MetGluIleGluLysGlnArgGly-66 77-AspTyrLysAspHisThr-82 92-GlnAspPheSerGluAspThrTyr-99 113-AspAlaAlaLysGlyValGlu-119 129-CysArgLeuArgAspThrPro-135 142-LysTyrAspArgGluValArgAspSerLeuGluLeuLeuAspGluValGluAsn-159 194-AlaGlyGlyGluArgLeuProHis-201 207-LysGlyIleAspAsnProGluLeuGluGlnArgPheProLeu-220 223-GlnGlnLeuArgAspGluIleGluLeu-231 277-ProLysProArgAspAlaThrValArgMetValGluProAspGluProLysPhe-294 305-MetAspProLysHisArgAspArgIleAla-314 319-CysSerGlyLysPheGluArgGlyMetLysMetLysHisLeuArgIleAsnArgGluIleAla-339 348-SerHisAspArgGluLeuValGlu-355 376-SerPheSerGluGlyGluGln-382 399-ValArgIleLysAsnProLeuLysIleLysGlnLeuGlnLysGlyLeu-414 417-LeuGlyGluGluGlyAla-422 473-SerCysAspAspLysLysLysLeuAlaGluPheGluLysAlaAsnAla-488 512-ThrGlnGluArgTrpPro-517 523-GluThrArgGluHisSerVal-529 135 AMPHI Regions - AMPHI 85-GluTyrThr laAsnLeu-90 169-AspIleAspGlyLeuTyrThr-175 185-ValArgLeuAspLysIleGluHis-192 212-GlyMetLeuThrLysIle-217 236-LeuLysProAspAla-240 242-AlaGluAlaAlaGlu-246 284-AlaGluHisAlaLeuSer-289 300-IleAlaGlyIleGluGly-305 308-SerArgMetAspThrValThrValTyr-316 318-LysAlaThrLysGlnPro-323 Antigenic Index - Jameson-Wolf l-MetLysTyrLysArgIleVal-7 H-GlyThrSerSerIleThrHisSerAspGlySerLeuSerArgGlyLysIleGlnThr-29 60-GlyPheLysLysArgProValLysIleAlaAspLysGlnAlaSer-74 90-LeuSerSerAspGlyIle-95 105-AlaAspPheAlaAspLysArgArgTyrGlnAsnAlaGlyGly-118 124-LeuGlnArgArgAlaVal-129 132-IleAsnGluAsnAspThrValSerValGluGluLeuLysIleGlyAspAsnAspThrLeu-151 176-GlyAsnProAsnSerAsnProAspAlaValArgLeuAspLysIleGluHisIleAsn-194 202-GlyGlySerGlySerAlaAsnGlyThrGly-211 215-ThrLysIleLysAla-219 224-AlaGluSerGlyVal-228 233-CysSerSerLeuLysProAspAlaLeuAlaGluAlaAlaGluHisGlnAlaAspGly-251 257-ArgAlaLysGlyLeuArgThrGlnLysGln-266 271-TyrSerGluSerArgGlySerValTyrValAspGluGlyAlaGluHisAlaLeuSerGluGlnGlyLysSer LeuLeu-296 305-GlyHisPheSerArgMetAspThr-312 317-SerLysAlaThrLysGlnProLeuGlyLysGlyArgVal-329 335-AlaAlaGluAspLeuLeuLysSer rgLysAlaLys-346 350-IleHisArgAspAspTrpIleSer-357 Hydrophilic Regions - Hopp-Woods l-MetLysTyrLysArgIleVal-7 16-ThrHisSerAspGlySerLeuSerArgGlyLysIle-27 60-GlyPheLysLysArgProValLysIleAlaAspLysGlnAlaSer-74 105-AlaAspPheAlaAspLysArgArgTyrGlnAsn-115 124-LeuGlnArgArgAlaVal-129 133-AsnGluAsnAspThrValSerValGluGluLeuLysIleGlyAspAsnAspThrLeu-151 178-ProAsnSerAsnProAspAlaValArgLeuAspLysIleGluHisIleAsn-194 215-ThrLysIleLysAla-219 236-LeuLysProAspAlaLeuAlaGluAlaAlaGluHisGlnAlaAsp-250 257-ArgAlaLysGlyLeuArgThrGlnLys-265 272-SerGluSerArgGly-276 278-ValTyrValAspGluGlyAlaGluHisAlaLeuSerGluGlnGlyLys-293 306-HisPheSerArgMetAspThr-312 318-LysAlaThrLysGlnProLeuGlyLysGlyArgVal-329 335-AlaAlaGluAspLeuLeuLysSerArgLysAlaLys-346 351-HisArgAspAspTrp-355 136 AMPHI Regions - AMPHI 37-LeuArgPheValAspAspCysLeuPro-45 50-IleArgGlnCysIleArgGln-56 84-GlnCysHisAspGlyIleLysGlnLeuPheLysArgPheIleIleAspGlyPheLysProIleGlyArgHis- 107 119-CysValLysIleAla-123 148-ArgHisCysGlnAsn-152 170-GlnHisPheGlyGlnPro-175 177-GluArgCysGlnPheVal-182 194-AsnLeuValAlaThr-198 210-GlnPheAlaGlnPro-214 216-PheGlyCysPheGlyLysPheSerGlyIleHis-226 * Antigenic Index - Jameson-Wolf l-MetGluThrAsnAla-5 38-ArgPheValAspAspCysLeu-44 48-ValAspIleArgGlnCysIle-54 69-LeuGlnThrAspSer-73 84-GlnCysHisAspGlyIleLysGlnLeuPhe-93 99-AspGlyPheLysProIleGlyArgHisAsnIle-109 139-IleArgHisArgGlyGlyCysPheHisArgHisCysGlnAsnGlnProPheAsp-156 159-ThrPheGlyGlyGlyLysLeuArg-166 171-HisPheGlyGlnProValGluArg-178 184-ProAlaGlnGlnArgArgHisLysThr-192 214-ProProPheGlyCysPheGlyLysPheSerGly-224 236-ProTyrTyrArgArgAsnAlaVal-243 Hydrophilic Regions - Hopp-Woods 48-ValAspIleArgGlnCysIle-54 87-AspGlyIleLysGlnLeuPhe-93 185-AlaGlnGlnArgArgHisLysThr-192 137 AMPHI Regions - AMPHI 24-LeuSerTyrIleLeuGlyPhe-30 49-ThrLysGluSerLeu-53 55-AspPheLeuThrTrpGly-60 78-PheSerAspTyrLeuAlaHisProLeuAspIlePheLysValTrpGluGlyGly-95 120-PheLeuLysLeuMetAspThrValAlaProLeuValPro-132 139-ArgIleGlyAsnPheIle-144 149-TrpGlyArgValThrAspIleAsnAlaPhe-158 178-ProLeuTrpAlaGluTrpLeuGlnGlnTyr-187 190-LeuProArgHisProSerGlnLeu-197 232-TyrGlyIlePheArgPheIleAlaGluPheAlaArgGlnProAspAspTyrLeuGly-250 Antigenic Index - Jameson-Wolf 36-LeuGlyArgArgArgIleAlaGln-43 48-PheThrLysGluSerLeuAspAsp-55 92-TrpGluGlyGlyMet-96 lll-LeuPheGlyArgLysHisGly-117 136-AlaSerGlyArgIle-140 164-ProGlnAlaArgTyrGluAspAlaGluAlaAlaAla-175 191-ProArgHisProSerGlnLeu-197 214-PheSerLysLysGlnArgSerThrGlyGln-223 241-PheAlaArgGlnProAspAspTyrLeu-249 277-PheGlyMetLysLysGlnHis-283 Hydrophilic Regions - Hopp-Woods 37-GlyArgArgArgIleAla-42 48-PheThrLysGluSerLeuAsp-54 112-PheGlyArgLysHisGly-117 166-AlaArgTyrGluAspAlaGluAlaAlaAla-175 216-LysLysGlnArgSerThrGly-222 241-PheAlaArgGlnProAspAspTyr-248 278-GlyMetLysLysGlnHis-283 138 AMPHI Regions - AMPHI 21-ProTyrIleArgArgPheSerGlySer-29 74-AsnAlaMetLeuGluLysVal-80 85-GluPheValGlnGlyMet-90 109-ValAsnLysGluIleValSerMetIleAsnThrTyrGly-121 152-IleGlyGlnValGlyThrValGluSerIle-161 163-ThrGlyLeuValLysGlyLeu-169 199-GlyLysLeuAlaGluGluLeu-205 213-MetThrAsnIleAlaGlyValMetAspLysThrGlyAsnLeuLeuThrLysLeuThr-231 234-ArgIleAspGluLeuIle-239 247-GlyMetLeuProLysIleAlaSerAlaValGluAlaAlaValAsn-261 276-AlaLeuLeuLeuGluIlePheThrAspAla-285 Antigenic Index - Jameson-Wolf l-MetGluSerGluAsnIle-6 9-AlaAlaAspLysAlaArgIleLeu-16 23-IleArgArgPheSerGlySer-29 35-TyrGlyGlyAsnAlaMetThr-41 43-ProAlaLeuLysGluGlyPheAla-50 68-GlyGlyGlyProGln-72 76-MetLeuGluLysValGlyLysLysGlyGluPhe-86 91-ArgValThrAspLysGluAlaMetAsp-99 109-ValAsnLysGluIle-113 128-SerGlyArgAspAspHisPheIleLysAlaLysLysLeuLeuIleAspThrProGluGlnAsnGlyValAsp IleGlyGln-154 159-GluSerIleAspThrGlyLeu-165 169-LeuIleGluArgGlyCysIle-175 182-GlyValGlyGluLysGlyGluAla-189 200-LysLeuAlaGluGluLeuAsnAlaGluLys-209 219-ValMetAspLysThrGlyAsnLeuLeuThrLysLeuThrProLysArgIleAspGluLeuIleAla-240 259-AlaValAsnGlyValLys-264 269-IleAspGlyArgLeuProAsnAla-276 292-LeuGlyGlyGlyGluAspAla-298 Hydrophilic Regions - Hopp-Woods l-MetGluSerGluAsn-5 9-AlaAlaAspLysAlaArgIleLeu-16 43-ProAlaLeuLysGluGlyPheAla-50 76-MetLeuGluLysValGlyLysLysGlyGluPhe-86 91-ArgValThrAspLysGluAlaMetAsp-99 109-ValAsnLysGluIle-113 128-SerGlyArgAspAspHisPheIleLysAlaLysLysLeuLeuIleAspThrProGluGlnAsnGlyValAsp -151 183-ValGlyGluLysGlyGluAla-189 200-LysLeuAlaGluGluLeuAsnAlaGluLys-209 219-ValMetAspLysThrGly-224 230-LeuThrProLysArgIleAspGluLeuIleAla-240 269-IleAspGlyArgLeu-273 294-GlyGlyGluAspAla-298 140-2 AMPHI Regions - AMPHI 23-ThrThrLeuSerAlaCysLeuGly-30 105-AspPheProAsnProAsnAspAlaTyrLysAsnLeuIle-117 139-ThrGlyGluSerValGlySerIleSerPhePro-149 201-AspIleArgHisValLysGluIleGlyHisIleAspLeuValSer-215 253-AlaAlaIleArgAsnAlaTrpValLysLeuGly-263 266-GlyValArgIleVal-270 282-ThrAlaAspLeuPheGlnIle-288 311-GlyIleArgLeuMetGlnGlnSerAsp-319 370-AspArgSerGlyGluLysPheLysArgGluMetTyr-381 415-ThrArgThrAsnPro-419 458-ThrAlaGlnAspIle-462 476-LeuAspAlaGlyLysAlaMetAsnGlyPro-485 608-TyrThrArgLeuGlyLysLeuLeuLys-616 673-SerLeuAspSerValGluLysThrAlaGly-682 696-AsnAlaAlaArgThrAlaSer-702 736-SerAlaThrProGluThrValGluThrAlaAla-746 763-ArgAlaAlaAlaAlaValGlnHisAlaAsnAlaAlaAspGlyValArgIlePheAsnSerLeuAlaAlaThr -786 803-LeuLysAlaValSerAspGlyLeuAsp-811 817-LeuArgValIleAlaGln-822 882-SerLeuPheAlaGly-886 894-IleGlyTyrLeuLysGlyLeuPheSerTyr-903 918-GluHisAlaGluGlySer-923 931-LeuGlyAlaLeuGly-935 980-GlyThrLeuValGlyLeu-985 1019-GlyGlyPheThrGlyAlaThr-1025 1040-ArgLeuValAlaGlyLeu-1045 1053-AsnGlyTrpAsnGlyLeuAlaArg-1060 Antigenic Index - Jameson-Wolf 1-MetArgThrThrPro-5 7-PheProThrLysThrPheLysProThr-15 30-GlyGlyGlyGlyGlyGlyThrSerAlaProAspPheAsnAlaGlyGlyThrGlyIleGlySerAsnSerArgA 1aThrThrAlaLys-58 67-IleLysAsnGluMetCysLysAspArgSerMet-77 79-CysAlaGlyArgAspAspValAlaValThrAspArgAspAlaLysIleAsnAlaProProProAsnLeuHisT hrGlyAspPheProAsnProAsnAspAlaTyrLysAsn-115 127-TyrThrGlyArgGlyValGlu-133 138-AspThrGlyGluSerValGlySerIleSerPhe-148 151-LeuTyrGlyArgLysGluHisGlyTyrAsnGluAsnTyrLysAsn-165 170-MetArgLysGluAlaProGluAspGlyGlyGlyLysAspIleGluAlaSerPheAspAspGluAlaValIle GluThrGluAlaLysProThrAspIleArgHisValLysGluIleGlyHis-210 220-GlyArgSerValAspGlyArgProAlaGlyGlyIleAlaProAspAla-235 241-AsnThrAsnAspGluThrLysAsnGluMet-250 262-LeuGlyGluArgGlyValArg-268 272-AsnSerPheGlyThrThrSerArgAlaGlyThrAlaAsp-284 288-IleAlaAsnSerGluGluGlnTyrArg-296 301-AspTyrSerGlyGlyAspLysThrAspGluGlyIleArg-313 315-MetGlnGlnSerAspTyrGlyAsn-322 327-IleArgAsnLysAsnMet-332 337-SerThrGlyAsnAspAlaGlnAlaGlnProAsnThr-348 355-TyrGluLysAspAlaGlnLys-361 368-GlyValAspArgSerGlyGluLysPheLysArgGluMetTyrGlyGluProGlyThrGluProLeuGluTyr GlySerAsnHis-395 412-ValArgPheThrArgThrAsnPro-419 446-MetSerAsnAspAsnLeuArgThr-453 467-ValAspSerLysPheGly-472 477-AspAlaGlyLysAlaMetAsnGlyProAla-486 492-AspPheThrAlaAspThrLysGlyThrSer-501 506-SerPheArgAsnAspIleSerGlyThr-514 516-GlyLeuIleLysLysGlyGlySerGln-524 529-GlyAsnAsnThrTyrThrGlyLysThrIleIleGluGlyGlySer-543 548-GlyAsnAsnLysSerAspMetArgValGluThrLysGly-560 568-AlaSerGlyGlySerLeuAsnSerAspGly-577 582-AlaAspThrAspGlnSerGlyAlaAsnGlu-591 593-ValHisIleLysGlySerLeuGlnLeuAspGlyLysGlyThrLeu-607 615-LeuLysValAspGly-619 629-MetSerAlaArgGlyLysGlyAlaGly-637 640-AsnSerThrGlyArgArgValPro-647 653-LysIleGlyGlnAspTyr-658 663-AsnIleGluThrAspGlyGlyLeu-670 675-AspSerValGluLysThrAlaGlySerGluGlyAspThrLeu-688 691-TyrValArgArgGlyAsnAlaAlaArgThrAlaSer-702 714-HisAlaValGluGlnGlyGlySerAsnLeuGlu-724 730-LeuAspAlaSerGluSerSerAlaThrProGluThrValGlu-743 745-AlaAlaAlaAspArgThrAspMetProGlyIleArgProTyrGly-759 772-AsnAlaAlaAspGly-776 788-TyrAlaAspSerThrAlaAla-794 797-AspMetGlnGlyArgArgLeuLysAlaValSerAspGlyLeuAspHisAsnGlyThrGlyLeu-817 823-ThrGlnGlnAspGlyGlyThrTrpGluGlnGlyGlyValGluGlyLysMetArgGlySerThrGln-844 849-AlaAlaLysThrGlyGluAsnThrThr-857 863-GlyMetGlyArgΞerThrTrpSerGluAsnSerAlaAsnAlaLysThrAspSerIle-881 887-IleArgHisAspAlaGlyAsp-893 902-SerTyrGlyArgTyrLysAsnSerIleSerArgSerThrGlyAlaAspGluHisAlaGluGlySerValAsn -925 943-AlaThrGlyAspLeuThrValGluGlyGlyLeuArg-954 961-AspAlaPheAlaGluLysGlySerAlaLeuGlyTrpSerGlyAsnSerLeuThrGluGlyThr-981 990-LeuSerGlnProLeuSerAspLys-997 1005-GlyValGluArgAspLeuAsnGlyArgAspTyrThrVal-1017 1027-AlaThrGlyLysThrGlyAlaArgAsnMetProHisThr-1039 1049-ValGluPheGlyAsnGlyTrp-1055 1062-SerTyrAlaGlySerLysGlnTyrGlyAsnHisSerGlyArgValGlyVal-1078 Hydrophilic Regions - Hopp-Woods 50-SerAsnSerArgAlaThrThrAlaLys-58 67-IleLysAsnGluMetCysLysAspArgSerMet-77 80-AlaGlyArgAspAspValAlaValThrAspArgAspAlaLysIleAsnAla-96 106-PheProAsnProAsnAspAlaTyr-113 138-AspThrGlyGluSerValGly-144 152-TyrGlyArgLysGluHisGlyTyr-159 170-MetArgLysGluAlaProGluAspGlyGlyGlyLysAspIleGluAlaSerPheAspAspGluAlaValIle GluThrGluAlaLysProThrAspIleArgHisValLysGluIleGlyHis-210 221-ArgSerValAspGlyArgProAlaGly-229 242-ThrAsnAspGluThrLysAsnGluMet-250 262-LeuGlyGluArgGlyValArg-268 278-SerArgAlaGlyThr-282 29O-AsnSerGluGluGlnTyrArg-296 303-SerGlyGlyAspLysThrAspGluGlyIleArg-313 327-IleArgAsnLysAsn-331 339-GlyAsnAspAlaGlnAla-344 355-TyrGluLysAspAlaGlnLys-361 368-GlyValAspArgSerGlyGluLysPheLysArgGluMetTyrGly-382 384-ProGlyThrGluProLeuGlu-390 412-ValArgPheThrArg-416 477-AspAlaGlyLysAlaMetAsn-483 493-PheThrAlaAspThrLysGlyThrSer-501 509-AsnAspIleSerGly-513 517-LeuIleLysLysGlyGlySer-523 550-AsnLysSerAspMetArgValGluThrLysGly-560 583-AspThrAspGlnSerGlyAlaAsnGlu-591 601-LeuAspGlyLysGly-605 615-LeuLysValAspGly-619 631-AlaArgGlyLysGly-635 642-ThrGlyArgArgValPro-647 664-IleGluThrAspGly-668 675-AspSerValGluLysThrAlaGlySerGluGlyAspThr-687 692-ValArgArgGlyAsnAlaAlaArgThrAlaSer-702 714-HisAlaValGluGlnGlyGlySerAsnLeu-723 730-LeuAspAlaSerGluSerSerAlaThrProGluThrValGlu-743 745-AlaAlaAlaAspArgThrAspMetProGly-754 772-AsnAlaAlaAspGly-776 797-AspMetGlnGlyArgArgLeuLysAlaValSerAspGlyLeuAspHisAsnGlyThr-815 833-GlyGlyValGluGlyLysMetArgGlySerThr-843 851-LysThrGlyGluAsnThrThr-857 872-AsnSerAlaAsnAlaLysThrAspSer-880 887-IleArgHisAspAlaGlyAsp-893 905-ArgTyrLysAsnSerIleSerArgSerThrGlyAlaAspGluHisAlaGluGlySerVal-924 961-AspAlaPheAlaGluLysGlySer-968 992-GlnProLeuSerAspLys-997 1005-GlyValGluArgAspLeuAsnGlyArgAspTyrThr-1016 1027-AlaThrGlyLysThrGlyAlaArgAsnMetPro-1037 141 AMPHI Regions - AMPHI ll-GlnSerSerThrMetArgProIleGlyGluIle-21 44-ProAlaGluAlaPheLysLeuPro-51 80-AlaAspAlaLeuArgHisIle-86 131-PheHisAlaIleGlyAla-136 139-AsnLeuLeuAlaAlaMetLeuAspAsn-147 174-GlnLeuArgAsnIleIleAspGlyMetGlyLysProValAspGlyValMetArgPro-192 212-AspIleSerAspLeuLysGluArgLeuGlyIleLeuVal-225 245-MetAlaAlaLeuLeuLysAspAlaIleLysProAsnLeu-257 259-GlnThrIleGluGlyThrPro-265 272-ProPheAlaAsnIleAlaHisGlyCysAsnSerValThrAlaThrArgLeuAlaLysHisLeuAlaAspTyr Ala-296 330-AlaThrValArgAla-334 351-LeuAspAlaLeuGluLysGlyLeuProAsnLeuLeuLysHisIleSerAsnLeuLysAsnValPheGly-37 3 406-SerLeuThrGluValTrpGlyLys-413 420-AspLeuAlaArgLysValValAsnAlaIleGluSerGln-432 473-IleAlaSerLeuGluLys-478 525-ValAlaLeuCysGlyAsnMetMetLysMetProGlyLeuProLysValProAlaAla-543 Antigenic Index - Jameson-Wolf 3-PheLysThrAspAlaGluIleAlaGlnSerSerThrMetArgProIleGly-19 27-LeuAsnAlaAspAsnIleGluProTyrGly-36 38-TyrLysAlaLysIleAsnProAlaGluAlaPheLysLeuProGlnLysGlnGlyArg-56 64-AsnProThrProAlaGlyGluGlyLysThrThr-74 81-AspAlaLeuArgHisIleGlyLysAspAla-90 94-LeuArgGluProSerLeuGlyPro-101 105-ValLysGlyGlyAlaAlaGlyGlyGly-113 151-GlnGlyAsnGluLeuAsnl1eAspProLysArgValLeuTrp-164 166-ArgValValAspMetAsnAspArgGlnLeuArgAsnIleIleAspGlyMetGlyLysProValAspGlyVal MetArgProAspGlyPheAspIle-197 211-LysAspIleSerAspLeuLysGluArgLeuGly-221 227-TyrAlaLysAspGlySerProValTyr-235 237-LysAspLeuLysAlaAsnGly-243 251-AspAlaIleLysProAsnLeu-257 287-ArgLeuAlaLysHisLeuAla-293 306-LeuGlyAlaGluLysPheCysAspIleLysCysArgLeuAlaGlyLeuLysProAspAla-325 335-LeuLysTyrAsnGlyGlyValGluArgAlaAsnLeuGlyGluGluAsnLeuAspAlaLeuGluLysGlyLeu ProAsnLeu-361 383-PheValSerAspAlaAspAlaGluLeuAlaMetIleGluLysAlaCysAla-399 411-TrpGlyLysGlyGlyAlaGlyGlyAlaAspLeuAlaArgLysValValAsn-427 429-IleGluSerGlnThrAsnAsnPheGly-437 444-LeuGlyIleLysAspLysIleArgAlaIleAla-454 458-TyrGlyAlaGluAspValAspPheSerAla-467 474-AlaSerLeuGluLysLeuGlyLeuAspLysMe Pro-485 494-SerLeuSerAspAsnAlaLys-500 503-GlyCysProGluAspPheArgIle-510 534-MetProGlyLeuPro-538 541-ProAlaAlaGluLysIleAspValAspAlaGluGly-552 Hydrophilic Regions - Hopp-Woods 3-PheLysThrAspAlaGluIleAlaGln-ll 38-TyrLysAlaLysIleAsnPro-44 46-GluAlaPheLysLeuProGlnLysGlnGlyArg-56 67-ProAlaGlyGluGlyLysThr-73 81-AspAlaLeuArgHisIleGlyLysAspAla-90 94-LeuArgGluProSer-98 155-LeuAsnl1eAspProLysArgValLeuTrp-164 166-ArgValValAspMetAsnAspArgGlnLeuArgAsnlleile-179 181-GlyMetGlyLysProValAspGlyValMetArgProAspGlyPhe-195 211-LysAspIleSerAspLeuLysGluArgLeuGly-221 228-AlaLysAspGlySer-232 237-LysAspLeuLysAla-241 287-ArgLeuAlaLysHisLeuAla-293 306-LeuGlyAlaGluLysPheCysAspIleLysCysArgLeuAlaGlyLeuLysProAspAla-325 339-GlyGlyValGluArgAlaAsnLeuGlyGluGluAsnLeuAspAlaLeuGluLysGlyLeu-358 383-PheValSerAspAlaAspAlaGluLeuAlaMetIleGluLysAlaCysAla-399 420-AspLeuAlaArgLysValValAsn-427 444-LeuGlyIleLysAspLysIleArgAlaIleAla-454 458-TyrGlyAlaGluAspValAspPheSerAla-467 474-AlaSerLeuGluLysLeuGlyLeuAspLysMetPro-485 503-GlyCysProGluAspPheArgIle-510 541-ProAlaAlaGluLysIleAspValAspAlaGluGly-552 142-2 AMPHI Regions - AMPHI 26-ArgPheAlaAlaMetProAspValValGlyLys-36 44-GlyGlnProGlyLysMetPhe-50 100-AlaValThrProCysArg-105 107-ValCysArgAspAspMet-112 130-PheLeuGlnIleArgHisPheSerProLeu-139 174-LeuArgValGlnArgIleLeuAspPheGlyLysPheCysGlnGlnVal-189 202-LeuAspSerValValAlaPheValHisPhePheAlaAspPheLeuIle-217 239-AlaAspAsnGlnThrArgPhePheLysAlaGly-249 259-AsnAlaArgLeuIleArgGlnIleLeuLys-268 Antigenic Index - Jameson-Wolf 3l-ProAspValValGly-35 38-LeuPheGlyArgGlnAlaGlyGlnProGlyLysMet-49 59-GlnArgIleAspAlaGluAlaAlaValPheArgGlnAspArgAsnAspSerArgThrProValAspAlaGlnH isHisGlyArgArgLeuValGlyAsnArgArgAspArgArgHisCysAsnAla-100 102-ThrProCysArgThrValCysArgAspAspMetAsnAlaCysArgAlaArgCysHisArgIleThrGluArg SerLeu-127 147-AlaAlaHisLysAlaSerPro-153 155-CysSerSerPheAspSerLysSerArgArgSerAspValSerAlaArgTyr-171 180-LeuAspPheGlyLysPheCys-186 225-GlnLeuGlnLysAsnThrSer-231 237-PheGlnAlaAspAsnGlnThrArgPhePheLysAlaGlyGlnAspThrGlyGlnAlaGlyAlaGlnAsn-25 9 267-LeuLysValGlnArgAlaValPheArgGlnLysThrAspAsnProPro-282 291-IleGlnAsnArgProGluLeuGlyHisGlnGly-301 307-GlnThrAspIleAspArgArgMetPhe-315 Hydrophilic Regions - Hopp-Woods 42-GlnAlaGlyGlnPro-46 59-GlnArgIleAspAlaGluAlaAlaValPheArgGlnAspArgAsnAspSerArgThrProValAspAlaGlnH isHisGlyArgArgLeuValGlyAsnArgArgAspArgArgHisCys-98 106-ThrValCysArgAspAspMetAsnAlaCysArgAlaArgCysHisArgIleThrGluArgSerLeu-127 147-AlaAlaHisLysAlaSerPro-153 158-PheAspSerLysSerArgArgSerAspValSerAla-169 237-PheGlnAlaAspAsnGlnThrArgPhePheLysAlaGlyGlnAspThrGlyGln-254 267-LeuLysValGlnArgAlaValPheArgGlnLysThrAspAsn-280 291-IleGlnAsnArgProGluLeuGly-298 309-AspIleAspArgArgMetPhe-315 144-2 AMPHI Regions - AMPHI 36-LeuGlyGlyIleValGlnGluPhe-43 45-ValLeuAlaAspGlyValArg-51 71-IleAsnLysGlnIleGlyArgValAlaGlyArg-81 136-SerAlaAspGlyTyr-140 212-SerAspAspLeuGluValPheAspPheSerArgProLys-224 * 234-ArgArgGluThrGlyArgAlaGlyPhe-242 244-AlaTyrArgValProSerAspIleGlyArgProAlaAla-257 283-ProGlnAspPheAlaArg-288 295-AspAlaLeuAlaThr-299 306-AspSerLeuAsnTrpProGluPheGlyAsn-315 Antigenic Index - Jameson-Wolf l-MetSerAspThrProAlaThrArgAspPheGlyLeuIleAspGlyArgAla-17 23-LeuSerAsnArgArgGlyThrArg-30 48-AspGlyValArgGlu-52 58-PheAspAspAlaAlaSerTyrAlaAspAsnProPheGlnlleAsn-72 78-ValAlaGlyArgIleArgGlyAlaAla-86 88-AspIleAsnGlyArgThrTyrArgValGluAlaAsnGluGlyArgAsnAlaLeuHisGlyGlySerHis-110 121-AlaAlaAspGlyArgSerValValLeu-129 131-SerArgLeuGlnGlnSerAlaAspGlyTyrProAsnAspLeuAspLeuAspIleSerTyrArgLeuAspGlu AspAspArgLeuThrVal-160 199-MetProAlaAspAlaGluLysLeuPro-207 210-ThrValSerAspAspLeuGluValPheAspPheSerArgProLysProLeuAsp-227 232-AlaLeuArgArgGluThrGlyArgAlaGlyPheAspAspAlaTyrArgValProSerAspIleGlyArgPro -255 261-AlaGlyArgArgArgArgIleΞerIleTyrSerAspArgAsnGly-275 282-AlaProGlnAspPheAlaArgHisAspAlaGlyVal-293 300-GluAlaGlnThrLeuProAspSerLeuAsnTrpProGlu-312 314-GlyAsnIleArgLeuAsnLysGlyAspThrArgGluAlaThr-327 Hydrophilic Regions - Hopp-Woods l-MetSerAspThrProAlaThrArgAsp-9 24-SerAsnArgArgGlyThrArg-30 48-AspGlyValArgGlu-52 58-PheAspAspAlaAlaSer-63 78-ValAlaGlyArgIleArgGlyAlaAla-86 89-IleAsnGlyArgThrTyrArgValGluAlaAsnGluGlyArgAsnAlaLeu-105 121-AlaAlaAspGlyArgSerValValLeu-129 131-SerArgLeuGlnGlnSerAlaAspGlyTyrProAsnAspLeuAspLeu-146 150-TyrArgLeuAspGluAspAspArgLeuThrVal-160 199-MetProAlaAspAlaGluLysLeuPro-207 210-ThrValSerAspAspLeuGluVal-217 221-SerArgProLysProLeuAsp-227 232-AlaLeuArgArgGluThrGlyArgAlaGlyPheAspAspAlaTyrArgValProSerAspIleGlyArg-25 4 261-AlaGlyArgArgArgArgIleSerIleTyrSerAspArgAsnGly-275 285-AspPheAlaArgHisAspAlaGlyVal-293 317-ArgLeuAsnLysGlyAspThrArgGluAlaThr-327 146 AMPHI Regions - AMPHI 19-LysGlnTyrGlyLeuLeuAspPheMetProCys-29 24-ProLeuAspAsnPheProThrVal-41 69-ValAlaAsnLeuArgArg-74 95-LeuArgAlaCysAlaValIleValAlaLysTyrValGlyValPheGlnLys-lll 140-AlaArgArgValArg-144 158-ArgHisGlnArgGlyPheAlaArg-165 191-ProIleValSerGlnTrpThrPro-198 Antigenic Index - Jameson-Wolf 6-LeuArgSerArgGlnValValIleAspHisAspLysValLysGln-20 30-LeuArgGlnProProLeuAspAsn-37 41-ValArgProAlaSerValGluAlaArgGlyLysTyrValGluArgArgArgGlnAspLysAspAlaAspGlyP heGlyGlnArg-68 7O-AlaAsnLeuArgArgAlaLeu-76 86-AlaCysArgArgGlnArgIleHisThr-94 112-SerPheLeuArgAspLysArgLeuLys-120 138-ArgArgAlaArgArgValArgHisGlyAsnAlaGln-149 155-GlnGlnProArgHisGlnArgGlyPheAla-164 166-AlaGlySerGlyArgAsnAspLysAspValAlaPheSerIle-179 Hydrophilic Regions - Hopp-Woods 6-LeuArgSerArgGlnValValIleAspHisAspLysValLysGln-20 44-AlaSerValGluAlaArgGlyLysTyrValGluArgArgArgGlnAspLysAspAlaAspGlyPheGly-66 70-AlaAsnLeuArgArgAlaLeu-76 86-AlaCysArgArgGlnArgIleHisThr-94 113 -PheLeuArgAspLysArgLeuLys-120 138-ArgArgAlaArgArgValArgHisGlyAsn-147 156-GlnProArgHisGlnArgGlyPheAla-164 167-GlySerGlyArgAsnAspLysAspValAla-176 148 AMPHI Regions - AMPHI 25-AlaAspLysIleArgLysIleGluAsnTrpPro-35 49-GlnSerAlaGluTyrPheArgLeuLeuValAspLeu-60 150-AlaGlyLeuGluLeuIleArgLysLeuGlyGlyGluIle-162 165-AlaAlaAlaIleLeuGluPheThrAspLeuGlnGlyGlyLysAsnIleArg-181 Antigenic Index - Jameson-Wolf 4-LysThrSerAsnLeu-8 24-LeuAlaAspLysIleArgLysIleGluAsnTrpProGlnLysGly-38 66-MetAspGlnLysIleAspIle-72 76-LeuAspAlaArgGly-80 97-ProIleArgLysLysGlyLysLeuPro-105 117-TyrGlyGluAlaAlaVal-122 124-IleHisThrAspAlaValLysLeuGlySer-133 153-GluLeuIleArgLysLeuGlyGlyGluIleValGlu-164 172-ThrAspLeuGlnGlyGlyLysAsnIleArgAlaSerGlyAlaPro-186 192-GlnAsnGluGlyCysMetLysGly-199 Hydrophilic Regions - Hopp-Woods 24-LeuAlaAspLysIleArgLysIleGluAsnTrpPro-35 66-MetAspGlnLysIleAspIle-72 97-ProIleArgLysLysGlyLysLeuPro-105 117-TyrGlyGluAlaAlaVal-122 124-IleHisThrAspAlaValLysLeuGlySer-133 153-GluLeuIleArgLysLeuGlyGlyGluIleValGlu-164 178-LysAsnIleArgAlaSerGly-184 195-GlyCysMetLysGly-199 149-2 AMPHI Regions - AMPHI 78-AsnLeuGlyAspAlaLeuAspGlyValProGlyIle-89 107-ThrGlyArgArgIleLysValLeuAsnHisHisGlyGluThrGlyAspMet-123 141-GlnValGluIleLeuArgGlyProValThr-150 158-ValAlaGlyLeuValAsp-163 170-ProGluLysMetProGluAsnGlyVal-178 190-AsnLeuGluLysLeu-194 226-TyrArgAsnLeuLysArgLeuProAspSerHis-236 351-PheProGlyPheGlu-355 372-AlaGlyAspAlaValGluAsnPhePheAsnAsn-382 395-ProIleGlyArgLeuLys-400 415-LeuSerAlaIleSerGluAlaVal-422 571-ArgPheGlyAsnTyrIleTyrAlaGln-579 582-AsnAspGlyArgGlyProLysSerIleGluAsp-592 633-ArgGlyArgLeuLysAsnLeuProSer-641 Antigenic Index - Jameson-Wolf 1-MetArgArgGluAlaLysMetAla-δ 31-HisGluThrGluGlnSerValAspLeuGluThr-41 46-GlyLysSerArgProArgAlaThrSerGly-55 61-ThrAlaSerAspLysIleIleSerGlyAspThrLeuArgGlnLysAla-76 103-IleArgGlyGlnThrGlyArgArgIleLysVal-113 115-AsnHisHisGlyGluThrGlyAspMetAlaAspPheSerProAspHis-130 143-GluIleLeuArgGlyPro-148 163-AspValAlaAspGlyLysIleProGluLysMetProGluAsnGlyValSerGlyGluLeuGlyLeu-184 186-LeuSerSerGlyAsnLeuGluLysLeuThrSerGlyGly-198 213-GlyLeuTyrArgLysSerGlyAspTyrAlaValProArgTyrArgAsnLeuLysArgLeuProAspSerHis AlaAspSerGlnThrGly-242 250-GlyGluLysGlyPhe-254 258-AlaTyrSerAspArgArgAspGlnTyrGly-267 269-ProAlaHisSerHisGluTyrAspAspCysHisAla-280 287-SerLeuIleAsnLysArgTyrLeu-294 301-LeuThrGluGluAspIleAspTyrAspAsnProGlyLeu-313 316-GlyPheHisAspAspAspAsnAlaHis-324 326-HisThrHisSerGlyArgProTrpIleAspLeuArgAsnLysArgTyrGluLeuArgAlaGluTrpLysGln ProPheProGly-353 360-HisLeuAsnArgAsnAspTyrArgHisAspGluLysAlaGlyAspAlaVal-376 380-PheAsnAsnGlnThrGlnAsnAlaArgIleGluLeuArgHisGlnProIleGlyArgLeuLysGlySerTrp -403 408-LeuGlnGlnLysSerSerAla-414 428-LeuAspAsnLysVal-432 443-AlaAsnTrpAspAsnPheThrLeuGluGlyGlyValArgValGluLysGlnLysAlaSerIleGlnTyrAsp LysAlaLeuIleAspArgGluAsnTyrTyrAsnHisProLeuProAsp-482 484-GlyAlaHisArgGlnThrAla-490 512-SerHisGlnGluArgLeuProSerThrGlnGluLeuTyrAlaHisGly-527 537-ValGlyAsnLysHisLeuAsnLysGluArgSerAsnAsnl1e-550 556-TyrGluGlyAspArgTrpGln-562 568-TyrArgAsnArgPheGlyAsn-574 580-ThrLeuAsnAspGlyArgGlyProLysSerIleGluAspAspSerGluMetLysLeu-598 600-ArgTyrAsnGlnSerGlyAlaAspPheTyrGlyAlaGluGly-613 615-1leTyrPheLysProThrProArgTyrArgl1e-625 627-ValSerGlyAspTyrValArgGlyArgLeuLysAsnLeuProSerLeuProGlyArgGluAspAlaTyrGly AsnArgPro-653 655-IleAlaGlnAspAspGlnAsnAlaProArgValProAla-667 677-SerLeuThrAspArglleAspAla-684 695-AsnLysLeuAlaArgTyrGluThrArgThrProGlyHis-707 713-GlyAlaAsnTyrArgArgAsnThrArgTyrGlyGluTrp-725 731-AlaAspAsnLeuLeu-735 745-PheLeuSerAspThrProGlnMetGlyArgSerPheThrGlyGlyVal-760 Hydrophilic Regions - Hopp-Woods 1-MetArgArgGluAlaLysMetAla-δ 31-HisGluThrGluGlnSerValAspLeuGluThr-41 46-GlyLysSerArgProArgAlaThr-53 61-ThrAlaSerAspLysIleIleSer-68 70-AspThrLeuArgGlnLysAla-76 106-GlnThrGlyArgArgIleLysVal-113 118-GlyGluThrGlyAspMetAlaAspPheSerPro-128 163-AspValAlaAspGlyLysIleProGluLysMetProGluAsnGlyValSer-179 187-SerSerGlyAsnLeuGluLysLeuThr-195 213-GlyLeuTyrArgLysSerGlyAsp-220 225-ArgTyrArgAsnLeuLysArgLeuProAspSerHisAlaAspSerGlnThr-241 259-TyrSerAspArgArgAspGlnTyr-266 273-HisGluTyrAspAspCysHisAla-280 301-LeuThrGluGluAspIleAspTyrAspAsn-310 317-PheHisAspAspAspAsnAlaHis-324 336-LeuArgAsnLysArgTyrGluLeuArgAlaGluTrp-347 360-HisLeuAsnArgAsnAspTyrArgHisAspGluLysAlaGlyAspAlaVal-376 384-ThrGlnAsnAlaArgIleGluLeuArgHis-393 397-GlyArgLeuLysGly-401 452-GlyGlyValArgValGluLysGlnLysAla-461 468-AlaLeuIleAspArgGluAsnTyr-475 484-GlyAlaHisArgGlnThrAla-490 512-SerHisGlnGluArgLeuProSer-519 541-HisLeuAsnLysGluArgSerAsnAsn-549 556-TyrGluGlyAspArgTrp-561 581-LeuAsnAspGlyArgGlyProLysSerIleGluAspAspSerGluMetLysLeu-598 609-TyrGlyAlaGluGly-613 619-ProThrProArgTyrArgIle-625 630-AspTyrValArgGlyArgLeuLysAsn-638 643-ProGlyArgGluAspAlaTyrGly-650 655-IleAlaGlnAspAspGlnAsnAlaProArgValProAla-667 677-SerLeuThrAspArgIleAspAla-684 696-LysLeuAlaArgTyrGluThrArgThrProGly-706 715-AsnTyrArgArgAsnThrArgTyrGly-723 150-2 AMPHI Regions - AMPHI 20-IleThrGlnLeuLeuSerGlyLeuAsp-28 80-ValAlaAspLysAlaAlaAspSerLeuGlu-89 138-AsnGlyLysLysAlaProLysLeu-145 159-SerTyrProAsnPheCysGlnAlaGlyLysAspPheAspArgArgPheGlu-175 198-AlaTrpThrAspAsnIleAla-204 223-ThrProProAlaGlyLeuGln-229 293-ArgGluIleLeuAspLeuLeu-299 316-ValAlaArgAlaLeuSer-321 333-PheValLysGlyTyrAlaAlaPheAlaHisTyrGluGluLeuAspLysIleIle-350 365-IleValAspValLeuHisArgPheProAlaSerLeu-376 379-GluGlnPheIleArgLeuLeuArgProLeuAla-389 468-GlyValAlaProPheArg-473 505-ThrGluTrpGlnGlnPheAlaLys-512 537-IleArgGluGlnAla-541 560-AlaAlaLysMetAlaLysAspValGluAlaAlaLeuLeuAspValIle-575 588-GluTyrLeuAspMetLeuArgGluGlu-596 Antigenic Index - Jameson-Wolf l-MetSerGluHisAspMetGlnAsnThrAsnProPro-12 16-LeuProProGluIle-20 42-LysAlaGlyAsnGlyAlaSerAlaGlyLeu-51 72-SerGlnThrGlyAsnAlaLysSerValAlaAspLysAlaAlaAspSerLeuGlu-89 96-SerArgAlaGluLeuLysAspTyrLysAlaLysAsnIleAlaGlyGluArgArgLeu-114 118-ThrSerThrGlnGlyGluGlyGluProProLysGluAlaValVal-132 137-LeuAsnGlyLysLysAlaProLysLeuAspLys-147 154-GlyLeuGlyAspSerSerTyrProAsnPheCysGlnAlaGlyLysAspPheAspArgArgPheGluGluLeu GlyAlaLysArgLeuLeuGluArgValAspAlaAspLeuAspPhe-192 207-LeuLysGluGluAlaAlaLysAsnArgAlaThrProAlaProGlnThrThrProProAlaGlyLeuGlnThr AlaProAspGlyArgTyrCysLys-238 250-GlnLysIleThrAlaArgGlnSerAspLysAspValArgHisIleGluIleAspLeuSerGlySerAspLeu -273 276-LeuProGlyAspAla-280 285-PheAspAsnAspProAlaLeuVal-292 302-AspProAlaThrGluIleGlnAlaGlyGlyLysMetMetPro-315 324-PheGluLeuThrGlnAsnThrProAlaPhe-333 344-GluGluLeuAspLysIleIleAla-351 397-SerAlaGlnAlaGluValGlyAspGluValHis-407 415-PheGluHisGluGlyArgAlaArgThrGlyGlyAlaSerGlyPheLeu-430 432-AspArgLeuGluGluAspGlyThrVal-440 443-PheValGluArgAsnAspGlyPheArgLeuProGluAspSerArgLysPro-459 464-GlySerGlyThrGly-468 478-GlnArgAlaAlaGluAsnAlaGluGlyLysAsn-488 509-GlnPheAlaLysAspGlyPheLeuHisArgTyrAspPheAlaTrpSerArgAspGlnGluGluLysIleTyr Val-533 535-AspLysIleArgGluGlnAlaGlu-542 559-AspAlaAlaLysMetAlaLysAspValGlu-568 579-GlyHisLeuAspGluGluGlyAlaGluGluTyrLeuAspMetLeuArgGluGluLysArgTyrGlnArgAsp ValTyr Hydrophilic Regions - Hopp-Woods l-MetSerGluHisAspMetGlnAsn-8 75-GlyAsnAlaLysSerValAlaAspLysAlaAlaAspSerLeuGlu-89 96-SerArgAlaGluLeuLysAspTyrLysAlaLysAsnIleAlaGlyGluArgArgLeu-114 120-ThrGlnGlyGluGlyGluProProLysGluAlaValVal-132 137-LeuAsnGlyLysLysAlaProLysLeuAspLys-147 166-AlaGlyLysAspPheAspArgArgPheGluGluLeuGlyAlaLysArgLeuLeuGluArgValAspAlaAsp LeuAspPhe-192 207-LeuLysGluGluAlaAlaLysAsnArgAlaThrPro-218 230-ThrAlaProAspGlyArgTyrCysLys-238 251-LysIleThrAlaArgGlnSerAspLysAspValArgHisIleGluIleAspLeuSerGly-270 288-AspProAlaLeuVal-292 344-GluGluLeuAspLysIleIleAla-351 398-AlaGlnAlaGluValGlyAspGluValHis-407 415-PheGluHisGluGlyArgAlaArgThrGlyGly-425 432-AspArgLeuGluGluAspGlyThrVal-440 443-PheValGluArgAsnAspGlyPheArgLeuProGluAspSerArgLysPro-459 479-ArgAlaAlaGluAsnAlaGluGlyLys-487 523-TrpSerArgAspGlnGluGluLysIleTyrVal-533 535-AspLysIleArgGluGlnAlaGlu-542 559-AspAlaAlaLysMetAlaLysAspValGlu-568 580-HisLeuAspGluGluGlyAlaGluGluTyrLeuAspMetLeuArgGluGluLysArgTyrGlnArgAspVal Tyr-604 151 AMPHI Regions - AMPHI 6-AsnIleAlaIleIleAla-ll 22-AspGlnLeuLeuArg-26 72-ValAspThrProGlyHis-77 81-GlyGlyGluValGluArgValLeuGlyMetValAspCysVal-94 128-LysIleAspLysPro-132 144-PheGluLeuPheAspAsnLeuGlyAlaThr-153 165-SerGlyLeuSerGlyPheAlaLysLeuGluGluThrAspGluSerAsn-180 184-ProLeuPheAspThrIleLeuLysTyrThr-193 248-GlyArgIleAsnGlnLeuLeuGlyPheLysGlyLeuGluArgVal-262 273-ValIleIleSerGlyIleGlu-279 330-IleArgAspArgLeuGlnLysGluLeu-338 348-AspThrAlaAspAla-352 396-CysGluProTyrGluAsnLeuThrValAsp-405 457-LeuThrArgGlyValGly-462 464-MetSerHisValPheAsp-469 537-LysGlyLysLysLeuThrAsnIle-544 551-GluAlaValArgLeuThrThr-557 Antigenic Index - Jameson-Wolf l-MetLysGlnIleArg-5 13-ValAspHisGlyLysThrThrLeu-20 24-LeuLeuArgGlnSerGlyThrPheArgAlaAsnGlnGlnValAspGluArgValMetAspSerAsnAspLeuG luLysGluArgGlyIle-53 59-AsnThrAlaIleAspTyrGluGlyTyr-67 72-ValAspThrProGlyHisAlaAspPheGlyGlyGluValGluArg-86 99-AspAlaGlnGluGlyProMetProGlnThrArgPheValThr-112 128-LysIleAspLysProSerAlaArgProSerTrp-138 151-GlyAlaThrAspGluGlnLeuAsp-158 171-AlaLysLeuGluGluThrAspGluSerAsnAspMe ArgProLeu-185 193-ThrProAlaProSerGlySerAlaAspGluThrLeu-204 211-LeuAspTyrAspAsnTyrThrGly-218 226-LeuAsnGlyArgIleLysProGlyGln-234 240-AsnHisAspGlnGlnIleAla-246 257-LysGlyLeuGluArgValProLeuGluGluAlaGluAlaGlyAsp-271 277-GlyIleGluAspIleGly-282 287-IleThrAspLysAspAsnProLysGlyLeuPro-297 300-SerValAspGluProThrLeu-306 314-ThrSerProLeuAlaGlyThrGluGlyLysPheValThrSerArgGlnIleArgAspArgLeuGlnLysGlu LeuLeu-339 344-LeuArgValGluAspThrAlaAspAlaAspValPheArgValSerGlyArgGlyGluLeu-363 371-AsnMetArgArgGluGlyTyr-377 381-ValGlyLysProArgValValTyrArgAspIleAspGlyGlnLysCysGluProTyrGluAsnLeuThrVal AspValProAspAspAsnGlnGlyAlaValMetGluGluLeuGlyArgArgArgGlyGluLeuThrAsnMetGluS erAspGlyAsnGlyArgThrArgLeuGluTyr-440 467-ValPheAspAspTyrAlaProValLysProAspMetProGlyArgHisAsnGly-484 489-GlnGluGlnGlyGlu-493 501-AsnLeuGluAspArgGlyArgMetPheValSerProAsnAspLysIleTyr-517 524-IleHisSerArgAspAsnAspLeu-531 535-ProLeuLysGlyLysLysLeuThrAsnIleArgAlaSerGlyThrAspGluAlaValArg-554 569-PheIleAspAspAspGluLeuValGlu-577 579-ThrProGlnSerIleArgLeuArgLysArgTyrLeuSerGluLeuGluArgArgArgHisPheLysLysLeu Asp-603 Hydrophilic Regions - Hopp-Woods l-MetLysGlnIleArg-5 29-GlyThrPheArgAla-33 35-GlnGlnValAspGluArgValMetAspSerAsnAspLeuGluLysGluArgGlyIle-53 80-PheGlyGlyGluValGluArg-86 99-AspAlaGlnGluGlyProMetPro-106 128-LysIleAspLysProSerAla-134 151-GlyAlaThrAspGluGlnLeuAsp-158 171-AlaLysLeuGluGluThrAspGluSerAsnAspMetArgProLeu-185 198-GlySerAlaAspGluThrLeu-204 226-LeuAsnGlyArgIleLysPro-232 241-HisAspGlnGlnIleAla-246 258-GlyLeuGluArgValProLeuGluGluAlaGluAlaGlyAsp-271 277-GlyIleGluAspIleGly-282 287-1leThr spLysAspAsnProLysGly-295 300-SerValAspGluProThrLeu-306 318-AlaGlyThrGluGlyLysPheValThr-326 328-ArgGlnlleArgAspArgLeuGlnLysGluLeuLeu-339 344-LeuArgValGluAspThrAlaAspAlaAspValPheArgValSerGlyArgGlyGluLeu-363 371-AsnMetArgArgGluGlyTyr-377 381-ValGlyLysProArgValValTyrArgAspIleAspGlyGlnLysCysGluProTyrGlu-400 405-AspValProAspAspAsnGlnGlyAlaValMetGluGluLeuGlyArgArgArgGlyGluLeuThrAsnMet GluSerAspGlyAsnGlyArgThrArgLeu-438 472-AlaProValLysProAspMetProGlyArgHis-482 489-GlnGluGlnGlyGlu-493 502-LeuGluAspArgGlyArgMet-508 512-ProAsnAspLysI1eTyr-517 525-HisSerArgAspAsnAspLeu-531 536-LeuLysGlyLysLysLeuThrAsn-543 545-ArgAlaSerGlyThrAspGluAlaValArg-554 569-PheIleAspAspAspGluLeuValGlu-577 583-IleArgLeuArgLysArgTyrLeuSerGluLeuGluArgArgArgHisPheLysLysLeuAsp-603 152 AMPHI Regions - AMPHI 10-LeuProThrArgLeuPhe-15 66-ArgPheSerArgPheValGlnGlyTrpAlaGlyIleArgGlyTyrLeuLysAsnGlyIleProGluHisIleG lnProGlyHisAsnProLeu-96 103-AlaLeuLeuAlaAla-107 130-LeuAsnHisLeuValSerGluHisThrGlySerLeu-141 150-PheLysLeuLeuAlaValPheSerAlaIleHisIleAlaAlaValAlaAlaTyr-167 Antigenic Index - Jameson-Wolf 1-MetLysAsnLysThrLysVal-7 29-SerAlaLysAlaGlyGlyAsp-35 61-GlySerAspThrAlaArgPheSerArg-69 79-GlyTyrLeuLysAsnGlyIleProGluHisIleGlnProGlyHisAsnProLeu-96 118-AlaAlaAspGluAsnThrPheSerThrAsnGlyTyr-129 137-HisThrGlySerLeuMetArg-143 169-ValPheLysLysLysAsnLeu-175 186-IleGluGlyLysThrSerIle-192 Hydrophilic Regions - Hopp-Woods l-MetLysAsnLysThrLysVal-7 63-AspThrAlaArgPhe-67 118-AlaAlaAspGluAsnThrPhe-124 169-ValPheLysLysLysAsnLeu-175 186-IleGluGlyLysThrSerIle-192 153 AMPHI Regions - AMPHI 17-AlaAlaSerValLeuSerLeuProGluMetMetArgLeuMetValPhe-32 96-ThrLeuValAlaTyrIleLysLeuSerSerValAlaGlu-108 130-ValSerValProGlnHisTrp-136 222-ValAsnThrIleLeuAsnGlyIleAlaTyr-231 274-AlaLysLysLeuSerHisLeuTyrArgIleThrGluAlaValGlyArgTrpSerMetIleAspIlePheVal Ile-298 Antigenic Index - Jameson-Wolf 65-IleArgLysGlnAla-69 81-ValArgLeuArgGln-85 107-AlaGluValArgPhe-lll 143-ArgLeuThrGlyAspAsnAlaValGlnThrAlaSerGluGlyLysThrCysCysSer-161 165-TyrPheArgAspSerAlaGluSerProCysGly-175 180-GluLeuTyrArgArgArgProLysSerLeuSer-190 215-SerAsnProAlaAlaThr-220 234-AspGluGlyAspArgLeu-239 272-ThrGlyAlaLysLysLeu-277 339-LeuLeuTrpAspLysArgAlaSerAspGlyIleAla-350 352-AsnGluThrGluLysHisAsp-358 Hydrophilic Regions - Hopp-Woods 81-ValArgLeuArgGln-85 107-AlaGluValArgPhe-lll 152-ThrAlaSerGluGlyLysThrCysCys-160 168-AspSerAlaGluSerPro-173 180-GluLeuTyrArgArgArgProLysSerLeuSer-190 234-AspGluGlyAspArgLeu-239 273-GlyAlaLysLysLeu-277 339-LeuLeuTrpAspLysArgAlaSerAsp-347 352-AsnGluThrGluLysHisAsp 154 AMPHI Regions - AMPHI 122-GlyValThrGlyLeuGlyThrLeuLeu-130 152-GlnAspIleProProValThr-158 262-ThrLysAsnSerLysAsnValLysSer-270 298-PheLysGlnSerVal-302 360-SerLysGluHisTrpLysGlnGlnPheGlnThrAlaLeuAsnLysGlyLeuThrAla-378 389-SerLysMetIleGluLeuAsnAsp-396 429-LysLeuAlaAspLeuLeuAspLysPheAspLysLeuPro-441 446-ValAlaGluLeuAsnGly-451 467-LeuSerSerIleAspLysLeuValGlyLysProGlnThrGlnAsnIleProAsnGluLeuAsnGlnThrLeu LysGluLeuArgThrThr-496 506-IleTyrGlyAspValGlnAsnThrLeuGlnSerLeuAspLysThrLeuLysAspValGlnProValIleAsn ThrLeuLysGluLys-534 Antigenic Index - Jameson-Wolf l-MetThrAspAsnSerProProProAsnGlyHisAlaGlnAlaArgValArgLysAsnAsnThr-21 43-LysGluIleArgAsnArgGlyProVal-51 57-AspSerAlaGluGlyIleGluValAsnAsnThr-67 75-AspValGlyArgValThrArgIleLysLeuArgAspAspGlnLysGlyValGlu-92 100-AspValSerGlyLeuIleArgSerAspThrGln-llO 114-ValLysProArgIleAspGlnSerGly-122 138-ThrProGlyLysSerAspGluAlaLysAspValPheGln-150 169-LeuIleGlyLysAsnAspArgIleLeuAsn-178 196-AlaHisPheAspProSerAspGlnSer-204 212-GlnSerProAsnAspLysLeuIle-219 228-GluSerGlyIleAsnIleGluThrThrGlySerGlyIleLysLeuAsnSer-244 256-SerPheAspSerProLysThrLysAsnSerLysAsnValLysSerGluAspSer-273 275-ThrLeuTyrAspSerArgSerGluValAlaAsnLeuProAspAspArgSerLeu-292 300-GlnSerValArgGlyLeu-305 311-ValGluTyrLysGlyLeuAsn-317 325-ProTyrPheAspArgAsnAspSer-332 345-IleArgIleGluProSerArgLeuGluIleAsnAlaAspGluGlnSerLysGluHisTrpLysGlnGlnPhe -368 37l-AlaLeuAsnLysGlyLeu-376 386-LeuThrGlySerLysMetIleGluLeuAsnAspGlnProSerAlaSerProLysLeuArgPro-406 419-GlnGlyGlyGlyLeuAspAspLeuGlnValLysLeu-430 432-AspLeuLeuAspLysPheAspLysLeuProLeuAspLysThrValAla-447 450-AsnGlySerLeuAlaGluLeuLysSerThrLeuLysSerAlaAsn-464 469-SerIleAspLysLeuValGlyLysProGlnThrGlnAsnIleProAsnGluLeuAsnGlnThrLeuLysGlu LeuArgThrThr-496 500-ValSerProGlnSer-504 516-SerLeuAspLysThrLeuLysAspValGln-525 530-ThrLeuLysGluLysProAsn-536 541-AsnSerSerSerLysAspProIleProLysGlySerArg-553 Hydrophilic Regions - Hopp-Woods l-MetThrAspAsnSerProProPro-8 12-AlaGlnAlaArgValArgLysAsnAsn-20 43-LysGluIleArgAsnArgGly-49 57-AspSerAlaGluGlyIleGlu-63 75-AspValGlyArgValThrArgIleLysLeuArgAspAspGlnLysGlyValGlu-92 105-IleArgSerAspThr-109 116-ProArgIleAspGln-120 140-GlyLysSerAspGluAlaLysAspValPheGln-150 171-GlyLysAsnAspArgIleLeu-177 196-AlaHisPheAspProSerAspGln-203 214-ProAsnAspLysLeuIle-219 258-AspSerProLysThrLysAsnSerLysAsnValLysSerGluAspSer-273 278-AspSerArgSerGluVal-283 285-AsnLeuProAspAspArgSer-291 311-ValGluTyrLysGly-315 328-AspArgAsnAspSer-332 345-IleArgIleGluProSerArgLeuGluIleAsnAlaAspGluGlnΞerLysGluHisTrpLys-365 390-LysMetIleGluLeuAsnAspGlnProSerAlaSerProLysLeuArgPro-406 421-GlyGlyLeuAspAspLeuGlnValLysLeu-430 432-AspLeuLeuAspLysPheAspLysLeuProLeuAspLysThrValAla-447 454-AlaGluLeuLysSerThrLeuLysSerAlaAsn-464 469-SerIleAspLysLeuValGly-475 482-IleProAsnGluLeu-486 498-GlnThrLeuLysGluLeuArgThr-495 516-SerLeuAspLysThrLeuLysAspValGln-525 530-ThrLeuLysGluLysProAsn-536 543-SerSerLysAspProIleProLysGlySerArg-553 155 AMPHI Regions - AMPHI 28-LysLeuGlyPheGlu-32 42-AlaAlaSerLeuAsp-46 105-LeuArgAlaLysLysVal-110 118-ValProArgIleSerArgAlaGlnAlaLeuAspAlaLeuSerSerMetAlaAsnIleSerGlyTyrArgAla ValIleGluAlaAlaAsnAlaPheGlyArgPhePheThrGly-155 175-ValAlaGlyLeuAlaAlaIleGlyThrAlaAsnSerLeuGlyAlaValValArgAlaPhe-194 201-AlaGluGlnIleGluSerMetGlyGly-209 225-AspGlyTyrAlaLysValMet-231 262-LysProAlaProLysLeuIleThrLysGluMetValGluSerMetLys-277 295-LeuThrArgProGlyGlu-300 308-ValLysIleIleGlyTyrThrAspMetAlaAsnArgLeuAlaGlyGln-323 330-ThrAsnLeuValAεnLeuThrLysLeuLeuSer-340 404-LysLeuAlaProAlaVal-409 428-AsnHisPheIleVal-432 451-LeuHisThrProLeuMetSerValThrAsnAlaIleSerGlyIleIle-466 469-GlyAlaLeuLeuGln-473 478-AsnGlyPheValSerLeuLeuSerPheValAla-488 494-IleAsnIlePheGlyGly-499 Antigenic Index - Jameson-Wolf 4-GlyIleProArgGluSerLeuSerGlyGluThrArgVal-16 44-SerLeuAspAspAlaAla-49 72-ValAsnAlaProSerGluGlnGluLeu-80 94-TrpProArgGlnAsnGluAlaLeu-101 105-LeuArgAlaLysLysValAsn-lll 117-MetValProArgIleSerArg-123 159-AlaAlaGlyLysValProProAla-166 194-PheAspThrArgLeuGluValAlaGluGlnl1eGluSerMetGlyGlyLys-210 215-AspPheProGlnGluSerGlyGlySerGlyAspGlyTyrAlaLysValMetSer-232 242-LeuPheAlaGluGlnAlaLysGluValAsp-251 259-IleProGlyLysProAlaProLysLeuIleThr-269 271-GluMetValGluSerMetLysSerGlySer-280 289-ThrGlyGlyAsnCysGluLeuThrArgProGlyGluLeuSerVal-303 320-LeuAlaGlyGlnSerSer-325 338-LeuLeuSerProAsnLysAspGlyGluIle-347 349-LeuAspPheGluAspValIle-355 361-ValThrHisAspGlyGluIleThrPhePro-370 378-AlaGlnProGlnGlnThrProSerGluLysAlaValProAlaAlaLysProGluProLysPro-398 Hydrophilic Regions - Hopp-Woods 4-Glyl1eProArgGluSerLeuSerGlyGluThrArgVal-16 44-SerLeuAspAspAlaAla-49 74-AlaProSerGluGlnGluLeu-80 96-ArgGlnAsnGluAlaLeu-101 105-LeuArgAlaLysLysValAsn-lll 117-MetValProArgIleSerArg-123 194-PheAspThrArgLeuGluValAlaGluGlnIleGluSerMetGly-208 215-AspPheProGlnGluSerGlyGlySerGlyAspGlyTyrAla-228 242-LeuPheAlaGluGlnAlaLysGluValAsp-251 260-ProGlyLysProAlaPro-265 271-GluMetValGluSerMetLysSer-278 291-GlyAsnCysGluLeuThrArgProGlyGlu-300 340-SerProAsnLysAspGlyGluIle-347 349-LeuAspPheGluAspValIle-355 363-HisAspGlyGluIle-367 382-GlnThrProSerGluLysAlaValProAlaAlaLysProGluProLysPro-398 156 AMPHI Regions - AMPHI 56-AsnGlyPheGluAlaPheAlaProPhe-64 Antigenic Index - Jameson-Wolf 21-TyrAlaLysLysAlaGlyGlyPheArgPheLysAspAsnHisAsnProArgGly-38 44-GlnGlyAlaAlaAla-48 51-HisAlaAlaGlnGlnAsnGlyPheGlu-59 73-AlaThrGlyAsnAlaAla-78 103-AspLysAlaAlaMet-107 Hydrophilic Regions - Hopp-Woods 21-TyrAlaLysLysAlaGlyGlyPheArgPheLysAspAsnHisAsnPro-36 103-AspLysAlaAlaMet-107 157 AMPHI Regions - AMPHI 21-GlyArgAspValArgAlaAla-27 32-IleAsnHisLeuLeuLysArg-38 61-PheValArgAlaAlaGln-66 167-GlnLeuValAspArg-171 176-AlaHisAspArgSerLeuAspGlyPhe-184 Antigenic Index - Jameson-Wolf 1-MetArgAsnGluGluLysArgAlaLeuArgArgGluLeuArgGlyArgArgSerGlnMetGlyArgAspValAr gAla-26 38-ArgTyrIleLysLysGlyArgLyslie-46 51-ProMetGlyLysGluLeuArgLeuAspGlyPheVal-62 64-AlaAlaGlnLysArgGlyAla-70 77-11eGluProArgSerArgArgMetTrp-85 89-TyrProAlaAspGlyValLysGlnGluArgLysArgGlyArgAlaLysLeuHis-106 lll-AlaGlyArgLysLysArgValHisAsp-119 129-GlyMetAspArgLeuGlyTyr-135 151-MetLysTyrArgLeuGlnAla-157 172-LeuProValGluAlaHisAspArgSerLeuAspGlyPheVal-185 Hydrophilic Regions - Hopp-Woods 1-MetArgAsnGluGluLysArgAlaLeuArgArgGluLeuArgGlyArgArgSerGlnMetGlyArgAspValAr gAla-26 38-ArgTyrIleLysLysGlyArgLysIle-46 54-LysGluLeuArgLeu-58 64-AlaAlaGlnLysArgGlyAla-70 77-11eGluProArgSerArgArg-83 92-AspGlyValLysGlnGluArgLysArgGlyArgAlaLysLeu-105 lll-AlaGlyArgLysLysArgValHisAsp-119 131-AspArgLeuGlyTyr-135 151-MetLysTyrArgLeuGlnAla-157 172-LeuProValGluAlaHisAspArgSerLeuAsp-182 158 AMPHI Regions - AMPHI 20-PheSerArgAlaAlaGluGlnLeu-27 33-AlaValSerArgIleValLysArgLeuGlu-42 46-GlyValAsnLeuLeuAsnArgThr-53 63-GlyAlaGlnTyrPheArgArgAlaGlnArgIleLeuGlnGlu-76 85-LeuAlaValHisGluIleProGln-92 166-ValIleAlaSerPro-170 178-ThrProGlnSerThrGluGluLeu-185 188-HisGlnCysLeuGlyPheThrGluProGlySerLeuAsnThrTrpAlaVal-204 Antigenic Index - Jameson-Wolf l-MetLysThrAsnSerGluGluLeu-8 16-GluSerGlySerPheSerArgAlaAlaGlu-25 36-ArgIleValLysArgLeuGluGluLysLeuGly-46 49-LeuLeuAsnArgThrThrArgGlnLeuSerLeuThrGluGluGlyAlaGlnTyrPheArgArgAlaGlnArgI leLeuGln-75 78-AlaAlaAlaGluThrGluMet-84 114-LysPheAsnGluArgTyrProHisIleArg-123 136-IleGluArgLysValAspIle-142 144-LeuArgAlaGlyGluLeuAspAspSerGlyLeuArgAla-156 158-HisLeuPheAspSerArgPheArgVal-166 168-AlaSerProGluTyrLeuAlaLysHisGlyThrProGlnSerThrGluGluLeuAla-186 192-GlyPheThrGluProGlySerLeuAsn-200 207-AlaGlnGlyAsnProTyrLysIle-214 216-ProHisPheThrAlaSerSerGlyGluIleLeu-226 229-LeuCysLeuSerGlyCys-234 243-LeuValAspAsnAspIleAlaGluGlyLysLeu-253 259-GluGlnThrSerAspLysThrHisProPhe-268 273-TyrSerAspLysAlaValAsnLeu-280 292-GluLeuGlyAsnAsnLeuCysGly-299 Hydrophilic Regions - Hopp-Woods l-MetLysThrAsnSerGluGluLeu-8 19-SerPheSerArgAlaAlaGlu-25 36-ArgIleValLysArgLeuGluGluLysLeuGly-46 58-SerLeuThrGluGluGlyAlaGlnTyrPheArgArgAlaGlnArgIleLeuGln-75 78-AlaAlaAlaGluThrGluMet-84 114-LysPheAsnGluArgTyrPro-120 136-IleGluArgLysValAspIle-142 144-LeuArgAlaGlyGluLeuAspAspSerGlyLeuArgAla-156 162-SerArgPheArgVal-166 180-GlnSerThrGluGluLeuAla-186 246-AsnAspIleAlaGluGlyLysLeu-253 260-GlnThrSerAspLysThrHis-266 276-LysAlaValAsnLeu-280 160 AMPHI Regions - AMPHI 6-LysLeuValAspPheAlaGlnLeuThrGly-15 72-GlyLeuGlyHisVal-76 121-AlaAspLeuMetAsnGlyLeuProGluThr-130 157-GlyThrValSerMetValAsnAlaLeuSerSer-167 186-LeuSerGlyValLeuLysGlyTrpGlnAspLysArg-197 200-HisLeuIleGlnLysValIleAspLysProGlu-210 218-MetValAlaAlaAlaAsn-223 229-LeuMetArgArgPhe-233 242-HisAlaPheValAsnHisIleArg-249 279-PheGlyLysAlaPheLys-284 Antigenic Index - Jameson-Wolf 2-AspIleLeuAspLysLeuVal-8 28-SerValArgHisGluThrLeuGlnArgGluGlyLeu-39 51-CysIleAspGlyGluThrSerProArgProValSerThrGlyAsp-65 77-LeuSerHisAspGlyLysCysGlyGluSerLeuGlnProAspMetArgGlnHisGly-95 lOl-GlnCysGlyAsnGlyGlnAspMet-108 115-PheArgTyrAspThrHisAla-121 123-LeuMetAsnGlyLeu-127 149-LeuGluSerLysLysProLeu-155 178-LeuGluGlnAspLysAspValGluLeu-186 192-GlyTrpGlnAspLysArgLeuGly-199 205-ValIleAspLysProGluAspGluTrpAsnValAspLysMetVal-219 228-GlnLeuMetArgArgPheLysSerArgValGlyLeuSerProHis-242 255-LeuLeuLeuLysLysAsnProAspSerVal-264 274-GlnSerGluThrHisPhe-279 281-LysAlaPheLysArg-285 290-SerProGlyGlnTyrArgLysGluGlyGlyGlnLys-301 Hydrophilic Regions - Hopp-Woods 2 -Aspl1eLeuAspLysLeuVal-8 29-ValArgHisGluThrLeuGlnArgGluGlyLeu-39 53-AspGlyGluThrSerProArgProValSer-62 79-HisAspGlyLysCysGlyGluSerLeuGlnProAspMetArgGln-93 lOl-GlnCysGlyAsnGlyGlnAsp-107 149-LeuGluSerLysLysProLeu-155 178-LeuGluGlnAspLysAspValGluLeu-186 193-TrpGlnAspLysArgLeuGly-199 205-ValIleAspLysProGluAspGluTrpAsnVal-215 228-GlnLeuMetArgArgPheLysSerArgValGly-238 255-LeuLeuLeuLysLysAsnProAspSer-263 281-LysAlaPheLysArg-285 293-GlnTyrArgLysGluGlyGlyGlnLys-301 163 AMPHI Regions - AMPHI 60-SerSerLeuGlyAsnIle-65 67-LeuGlyArgAspGluAsp-72 76-PheGlyPheLeuSerTrpLeuAlaMetLeuPhe-86 100-AlaGluProLeuMetHisTyrPheSerAspIleThrAla-112 170-IleSerGlyArgPheGlyAspAlaIleAspIleMetAlaLeuLeuAlaThrPhePheGlyIleIleThrThr -193 227-MetSerLeuAlaValValSerAlaIleSerGlyValGlyLysGlyValLysValLeuSer-246 272-AlaPheGlyAspAsnIleGlyAsnTyrLeuGlyAsnLeuValArg-286 313-TrpCysSerTrpAlaProPheValGlyLeuPheIleAla-325 346-LeuPheGlyValLeuTrpPhe-352 367-AlaGlyGlyMetLeuGluLysMetThrSerSer-377 380-ThrLeuLeuPheLysPhePheAsnTyrLeuProLeuProGluLeuThrSerIleValSerLeuLeu-401 438-TrpGlyValLeuMetSerAla-444 454-GlyLeuGlyAsnLeuGlnSerMetThrLeu-463 520-GluGlnAspIleLeuLysPheLeuLysGlnThrAlaSerPro-533 535-MetHisGluLeuGlnArgGluLeu-542 574-AspPheMetTyrGlyIle-579 583-GlyGlnAspValSerAspGlnLeu-590 630-AlaAspI1eLeuLysAsnTyr-636 Antigenic Index - Jameson-Wolf 29-AspArgAlaLysGlu-33 65-IleArgLeuGlyArgAspGluAspValPro-74 lll-ThrAlaGlyThrProGluHisArgGlnGln-120 166-LeuLysGluLysIleSerGlyArgPheGlyAspAlaIleAsp-179 200-GlnLeuGlyAlaGlyLeu-205 237-GlyValGlyLysGlyValLysVal-244 293-AlaTyrGluArgGluHisLysProTrpPhe-302 326-ArgIleSerLysGlyArgThrIleArg-334 370-MetLeuGluLysMetThrSerSerProGlu-379 409-ThrSerAlaAspSerGlyIle-415 421-IleThrSerArgAspLysGlyLeuSerAlaProArgTrp-433 451-ArgSerGlyGlyLeuGlyAsn-457 484-LeuSerAlaAspLysLysTyrPheGluThrArgValAsnProThrSer-499 503-ThrGlyGlyLysTrpLysGluArgLeu-511 516-SerGlnThrGlnGluGlnAspIle-523 527-LeuLysGlnThrAlaSer-532 537-GluLeuGlnArgGluLeuSerGluGluTyrGlyLeu-548 550-ValArgValAspLysMetPheHisArgAspGluProAla-562 566-ValIleArgLysGluThrMetArg-573 581-SerValGlyGlnAspValSerAspGlnLeuIleAsnAspGlyLysLeuProHisIleArgHisGlnThrThr TyrLysProTyr-608 612-PheAspGlyArgValGlyTyr-618 622-TyrMetAsnLysAspGluLeuIle-629 632-IleLeuLysAsnTyrGlu-637 654-GluGlnValGluLeuAlaGlu-660 Hydrophilic Regions - Hopp-Woods 29-AspArgAlaLysGlu-33 66-ArgLeuGlyArgAspGluAspValPro-74 114-ThrProGluHisArgGlnGln-120 166-LeuLysGluLysIleSerGlyArgPheGlyAsp-176 238-ValGlyLysGlyValLysVal-244 293-AlaTyrGluArgGluHisLysPro-300 327-IleSerLysGlyArgThrIleArg-334 370-MetLeuGluLysMetThrSerSerPro-378 422-ThrSerArgAspLysGlyLeuSer-429 484-LeuSerAlaAspLysLysTyrPheGlu-492 506-LysTrpLysGluArgLeu-511 517-GlnThrGlnGluGlnAspIle-523 537-GluLeuGlnArgGluLeuSerGluGluTyrGlyLeu-548 550-ValArgValAspLysMetPheHisArgAspGluProAla-562 566-ValIleArgLysGluThrMetArg-573 581-SerValGlyGlnAspValSerAsp-588 590-LeuIleAsnAspGlyLysLeuProHis-598 622-TyrMetAsnLysAspGluLeuIle-629 654-GluGlnValGluLeuAlaGlu-660 164 AMPHI Regions - AMPHI 6-AlaAsnPheTyrGluMetLeuAlaAlaAla-15 33-AlaTyrArgAlaLeuLysGlnGlu-40 75-AlaIleSerAlaIleGlyAlaVal-82 97-TyrIleLeuAsnAspCys-102 113-LeuSerLysGluLeuAlaGlyLeuLysAla-122 148-PheGluAspValArgArgPheProGlu-156 160-LeuGlyArgGlnProArgIleAsnAspLeuAlaHis-171 189-TyrAlaAsnLeuPheAlaAsnLeuAsnGlyIleGluArgIlePheLys-204 264-ValProAlaIleTyrThr-269 282-TrpPheAsnArgIle-286 311-AlaLysLeuLeuGluGlyTyrGlyLeuSer-320 362-GluValGlyGluLeuIle-367 374-MetArgGlyTyrLeuAsn-379 387-ThrIleValAsnGlyTrpLeuLys-394 424-ValTyrProArgGluIleGluGluGlu-432 459-PheValGlnLeuLysGluGlyMet-466 472-GluIleArgArgHisLeuArgThrVal-480 484-PheLysIleProLysGln-489 499-AsnAlaThrGlyLysValLeuLysArgValLeuLysGluGlnPheAspGlyAsn-516 Antigenic Index - Jameson-Wolf 1-Met snArgThrTyr-5 15-AlaCysArgLysAsnGlyAsnGly-22 26-PheAspGlyLysGluLysThrAlaTyrArgAlaLeuLysGlnGluAlaGluAla-43 63-ValSerAsnSerThrGlu-68 88-ThrPheLeuLysAsnSerGlu-94 100-AsnAspCysLysAla-104 112-GlyLeuSerLysGluLeuAlaGly-119 121-LysAlaGlnThrProValGlu-127 130-IleTrpThrAspLysSerArgProThrGlyGluThrAlaGluGlyAspAlaPhePheGluAspValArgArg PheProGluLysProAspLeuGlyArgGlnProArgIleAsnAsp-168 176-SerGlyThrThrGlyHisProLysGlyAla-185 196-LeuAsnGlyIleGluArgIlePheLysIleSerLysArgAspArgPhe-211 253-ThrLeuLeuLysArg-257 290-IleSerGlyGlyAlaProLeuAla-297 304-PheLysAlaLysPheProArg-310 317-TyrGlyLeuSerGluAlaSer-323 330-ThrProGluArgGlnLysAlaArgSer-338 343-LeuProGlyLeuGluAlaLysAlaValAspGluGluLeuValGluValProArgGlyGluValGly-364 367-IleValArgGlyGlySerValMet-374 382-AlaAlaThrAspGluThrIle-388 393-LeuLysThrGlyAsp-397 400-ThrIleAspGluAspGly-405 410-ValAspArgLysLysAspLeuIleIleSerLysGlyGlnAsnValTyrProArgGluIleGluGluGluIle TyrLys-435 446-GlyValLysAspArgTyrAlaAspGluGluIle-456 462-LeuLysGluGlyMetAspLeuGlyGluAsnGluIleArgArgHisLeuArg-478 490-IleHisPheLysAspGlyLeuProArgAsnAlaThrGlyLysValLeuLysArgValLeuLysGluGlnPhe AspGlyAsnLys-517 Hydrophilic Regions - Hopp-Woods 15-AlaCysArgLysAsnGlyAsn-21 26-PheAspGlyLysGluLysThrAlaTyrArgAlaLeuLysGlnGluAlaGluAla-43 112-GlyLeuSerLysGluLeuAlaGly-119 133-AspLysSerArgProThrGlyGluThrAlaGluGlyAspAlaPhePheGluAspValArgArgPheProGlu LysProAspLeuGlyArgGlnProArgIleAsnAsp-168 198-GlyIleGluArgIlePheLysIleSerLysArgAspArgPhe-211 253-ThrLeuLeuLysArg-257 304-PheLysAlaLysPheProArg-310 330-ThrProGluArgGlnLysAlaArgSer-338 346-LeuGluAlaLysAlaValAspGluGluLeuValGluValProArgGlyGluValGly-364 382-AlaAlaThrAspGluThrIle-388 400-ThrIleAspGluAspGly-405 410-ValAspArgLysLysAspLeuIleIle-418 425-TyrProArgGluIleGluGluGluIleTyrLys-435 446-GlyValLysAspArgTyrAlaAspGluGluIle-456 462-LeuLysGluGlyMetAspLeuGlyGluAsnGluIleArgArgHisLeuArg-478 494-AspGlyLeuProArgAsnAlaThr-501 503-LysValLeuLysArgValLeuLysGluGlnPheAspGlyAsnLys-517 165-1 AMPHI Regions - AMPHI 17-AlaThrLeuGlyValLeuLeuLysGluLeu-26 33-ThrLeuIleGluArgLeuGluAsp-40 72-IleIleAspProAlaArgAlaLeuAsnIleAla-82 90-GlnPheTrpAlaThr-94 108-AsnAlaValProHis-112 125-LeuGlnLysArgTyrAspAlaPheLysThrGlnLysLeuPheGluAsnMet-141 182-ArgLeuThrArgGlnMetValLysTyrLeuGlnGly-193 198-ThrGluPheAsnArgHisValGluAspIleLysArgGlu-210 348-GlyTrpAlaAsnMetPro-353 364-LysThrLysGluGlu-368 371-AlaSerLeuLeuGluTyrTyr-377 453-TrpGluAspArgLeuLysGluLeu-460 Antigenic Index - Jameson-Wolf l-MetAlaGluAlaThrAsp-6 24-LysGluLeuGluProSerTrp-30 36-GluArgLeuGluAspValAlaLeuGluSerSerAsnAlaTrpAsnAsnAlaGlyThrGly-55 97-AlaGluGlyLysLeuGluAspAsnSer-105 117-MetAsnGluAspHisCysSerTyrLeuGlnLysArgTyrAspAlaPheLysThrGlnLysLeuPheGlu-13 9 141-MetGluPheSerThrAspArgAεnLysIleSerAsp-152 157-MetMetArgGlyArgAspGluAsnGlnPro-166 169-AlaAsnTyrSerAlaGluGlyThrAspValAspPheGlyArgLeuThrArgGlnMet-187 191-LeuGlnGlyLysGlyValLysThrGluPheAsnArgHisValGluAspIleLysArgGluΞerAspGly-21 3 319-ThrAlaAspThrArgAsnProAspGlyGlnLeu-229 249-GlnLysSerGlyIleProGluGlyLysGlyTyrGly-260 269-PheArgAsnSerAsnProGluThrAlaGluGlnHisAsn-281 300-LeuAspThrArgAsnValAspGlyLysArgHisLeu-311 322-AsnPheLeuLysGlnGlySerLeuMet-330 361-GluLeuArgLysThrLysGluGluArgPhe-370 377-TyrProGluAlaAsnProAspAspTrpGlu-386 395-GlnIleIleLysLysAspSerGluLysGlyGly-405 415-AlaHisAlaAspGlySer-420 428-SerProGlyAlaSerThr-433 446-PheProGluArgAlaProSerTrpGluAspArgLeuLysGluLeuValProGlyTyr-464 467-LysLeuAsnGluAsnProGluArgAlaAspGlu-477 Hydrophilic Regions - Hopp-Woods l-MetAlaGluAlaThrAsp-6 24-LysGluLeuGluPro-28 36-GluArgLeuGluAspValAlaLeuGluSer-45 97-AlaGluGlyLysLeuGluAspAsnSer-105 117-MetAsnGluAspHisCys-122 125-LeuGlnLysArgTyrAspAlaPheLysThr-134 141-MetGluPheSerThrAspArgAsnLysIleSerAsp-152 158-MetArgGlyArgAspGluAsnGlnPro-166 172-SerAlaGluGlyThrAspValAspPhe-180 182-ArgLeuThrArgGlnMet-187 194-LysGlyValLysThrGluPheAsnArgHisValGluAspIleLysArgGluSerAspGly-213 219-ThrAlaAspThrArgAsnProAspGly-227 252-GlyIleProGluGlyLysGly-258 272-SerAsnProGluThrAlaGluGlnHisAsn-281 300-LeuAspThrArgAsnValAspGlyLysArg-309 361-GluLeuArgLysThrLysGluGluArgPhe-370 380-AlaAsnProAspAspTrpGlu-386 395-GlnIleIleLysLysAspSerGluLysGlyGly-405 446-PheProGluArgAlaProSerTrpGluAspArgLeuLysGluLeuVal-461 467-LysLeuAsnGluAsnProGluArgAlaAspGlu-477 Hydrophilic Regions - Hopp-Woods l-MetAlaGluAlaThrAsp-6 24-LysGluLeuGluPro-28 36-GluArgLeuGluAspValAlaLeuGluSer-45 97-AlaGluGlyLysLeuGluAspAsnSer-105 117-MetAsnGluAspHisCys-122 125-LeuGlnLysArgTyrAspAlaPheLysThr-134 141-MetGluPheSerThrAspArgAsnLysIleSerAsp-152 158-MetArgGlyArgAspGluAsnGlnPro-166 172-SerAlaGluGlyThrAspValAspPhe-180 182-ArgLeuThrArgGlnMet-187 194-LysGlyValLysThrGluPheAsnArgHisValGluAspIleLysArgGluSerAspGly-213 219-ThrAlaAspThrArgAsnProAspGly-227 252-GlyIleProGluGlyLysGly-258 272-SerAsnProGluThrAlaGluGlnHisAsn-281 300-LeuAspThrArgAsnValAspGlyLysArg-309 361-GluLeuArgLysThrLysGluGluArgPhe-370 380-AlaAsnProAspAspTrpGlu-386 395-GlnIleIleLysLysAspSerGluLysGlyGly-405 446-PheProGluArgAlaProSerTrpGluAspArgLeuLysGluLeuVal-461 467-LysLeuAsnGluAsnProGluArgAlaAspGlu-477 204-2 AMPHI Regions - AMPHI 43-GlnAlaPheAsnArgIleThrAspLeuPhePhe-53 62-AlaLeuSerGlnIle-66 70-AsnArgArgIleValAspIlePheAspPheGluAsn-81 83-PheArgArgAlaLeuTyrArgValLeuArgLeuPheArgArgIlePheGly-99 Antigenic Index - Jameson-Wolf 34-AspGlnSerAspAsnIleLeu-40 44-AlaPheAsnArgIle-48 66-11eGlnThrGlyAsnArgArgl1eValAsp-75 77-PheAspPheGluAsnArgPheArgArgAlaLeu-87 10l-AlaAlaGlyGlyLysGlnGlnAla-108 112-TyrGlyLysArgCysPhe-117 126-SerLysCysArgLeuLysArgGlyArgArgArgPheGlyArgHisArgValHisPheAsnGlyArgMetPro ThrAlaSerArgThrLeuSerAsnAsnSerArgAlaSerLeu-163 169-ProAlaCysLysIle-173 177-CysGluGlySerAla-181 Hydrophilic Regions - Hopp-Woods 68-ThrGlyAsnArgArgIleValAsp-75 77-PheAspPheGluAsnArgPheArgArgAlaLeu-87 104-GlyLysGlnGlnAla-108 112-TyrGlyLysArgCysPhe-117 126-SerLysCysArgLeuLysArgGlyArgArgArgPheGlyArgHisArgVal-142 148-MetProThrAlaSerArgThrLeuSerAsnAsnSerArgAlaSerLeu-163 205-1 (same as orflOδ, so delete this one) AMPHI Regions - AMPHI 21-SerGluAsnThrAlaGluGlnProGlnAsnAlaValGlnSerAlaProLys-37 79-GluGlnAsnValIleArgLeuIleGlyLysHisProGlyAspLeu-93 119-HisThrLeuPheAlaLysLeuValGlyAsnIleAlaGluAspGlyGlyLys-135 Antigenic Index - Jameson-Wolf 18-CysGlyLysSerGluAsnThrAlaGluGlnProGlnAsnAlaValGlnSerAlaProLysProValPhe-40 55-LeuGlyGlnSerSerGluGlyLysThrAsnAspGlyLysLysGlnIle-70 73-ProIleLysGlyLeuProGluGlnAsnVal-82 86-IleGlyLysHisProGlyAspLeuGluAlaValSerGlyLysCysMetGluThrAspAspLysAspSerProA laGlyTrpAlaGlu-114 129-IleAlaGluAspGlyGlyLysLeuThr-137 149-TyrGlnAlaGlyLysSerGlyTyr-156 168-IleAspSerGluGly-172 175-TyrPheArgArgArgHisTyr-181 Hydrophilic Regions - Hopp-Woods 19-GlyLysSerGluAsnThrAlaGluGlnProGln-29 56-GlyGlnSerSerGluGlyLysThrAsnAspGlyLysLysGlnIle-70 89-HisProGlyAspLeuGluAlaValSer-97 99-LysCysMetGluThrAspAspLysAspSerPro-109 129-IleAlaGluAspGlyGlyLysLeu-136 150-GlnAlaGlyLysSerGly-155 168-IleAspSerGluGly-172 176-PheArgArgArgHisTyr-181 206-2 AMPHI Regions - AMPHI 32-ProLysGlnThrValArgGlnIleGlnAlaVal-42 44-IleSerHisIleAspArgThrGlnGly-52 81-CysSerGlyMetIleGln-86 99-ArgThrAlaArgAspMet-104 150-SerGlyLysThrIleLysThrGlu-157 Antigenic Index - Jameson-Wolf 2-PheProProAspLysThrLeu-8 21-GlyThrThrSerGlyLysHisArgGlnProLysProLysGlnThrValArg-37 45-SerHisIleAspArgThrGlnGlySerGln-54 66-ThrProTyrLysTrpGlyGlySerSerThr-75 96-LysLeuProArgThrAlaArgAspMetAlaAlaAlaSerArgLysIleProAspSerArgLeuLysAlaGly- 119 126-ThrGlyGlyAlaHisArgTyrSer-133 148-ProSerSerGlyLysThrIleLysThrGluLysLeuSer-160 Hydrophilic Regions - Hopp-Woods 23-ThrSerGlyLysHisArgGlnProLysProLysGlnThrVal-36 45-SerHisIleAspArgThrGlnGlySerGln-54 96-LysLeuProArgThrAlaArgAspMetAlaAlaAlaSerArgLysIleProAspSerArgLeuLysAlaGly- 119 149-SerSerGlyLysThrIleLysThrGluLysLeuSer-160 211-2 AMPHI Regions - AMPHI 18-ValGlyAsnGlyValAspGluPheGlyArgGlyAla-29 57-GlnPheGluArgAla-61 98-IleGluGlyPheAspLysIleAsnProAla-107 Antigenic Index - Jameson-Wolf 8-AsnGlnLeuGlyGlyArgAsnGlyThrAlaValGlyAsnGlyValAspGluPheGlyArgGlyAlaAspAsnGl nValGluPheLeuGlu-37 44-GlyAlaSerGlyArgAlaAla-50 73-GlyGluAspAspValVal-78 100-GlyPheAspLysIleAsnProAlaVal-108 Hydrophilic Regions - Hopp-Woods 10-LeuGlyGlyArgAsnGlyThr-16 21-GlyValAspGluPheGlyArgGlyAlaAspAsnGlnValGluPheLeuGlu-37 73-GlyGluAspAspValVal-78 100-GlyPheAspLysIleAsn-105 212-2 AMPHI Regions - AMPHI 6-TrpAspGlylleProAspIleArgThr-14 40-PheGlnThrAlaGlnAsp-45 64-LeuGlnPheAspSerIleAsnLeuIleGluHisIle-75 91-HisLeuHisGluHis-95 199-ArgLeuLeuGlyHis-203 238-HisAsnHisLeuTyrArgSerIleThrSerAlaGluAlaGluLysIle-253 397-TrpAsnGluAlaGluGluAla-403 439-AspSerProAspHis-443 445-ProLeuValGlyAlaLeuGlyAspIleAlaAlaMet-456 487-HisGlyThrArgGlyLeu-492 501-AlaIleAlaAlaGlnIleLeuGlyLeuPro-510 Antigenic Index - Jameson-Wolf 8-GlyIleProAspIleArgThrLeuAspGlnAlaIleArgLysHisAlaProProLeuAsn-27 33-ProAspAsnGlnIleProAspPheGlnThrAlaGlnAspAlaSerAspAlaGluCysArgLeuLysHisArgL euAspGln-59 85-ProProSerArgThr-89 105-AlaIleProGlnThrGluSerLysProAspLysProTrp-117 120-LeuProGlnThrSerGluArgGlnLysProGluHis-131 158-LeuGluAlaArgLysAlaAlaGln-165 168-SerGlyAsnArgGlnGly-173 178-LysIleSerProHisAspThrGluGlnThrGlu-188 193-GlyTyrGlyTyrThrLys-198 205-LeuProGluSerGluThrTrpGlyGlyAsnGly-215 220-AsnTyrSerArgThrGluGlnGlnArgAsnHisGluLeuGlyLeu-234 246-ThrSerAlaGluAlaGluLysIleAla-254 260-ValProTyrAspHisProSerCys-267 294-LeuHisGluAspThrProLeu-300 302-AspIleSerHisAspGlyGluLysTrpIle-311 328-ThrGlyAlaAsnSerProTyrLeuPro-336 346-ArgGlnIleArgGlyGlnThrGlyLeuThrProSerThrProPheSerGluGlnLeuArg-365 376-ProSerTrpHisGly-380 391-AsnSerSerHisThrGlyTrpAsnGluAlaGluGluAlaSerAsnArgGlnAla-408 424-AsnProAsnProGlnLysHisGlnGly-432 436-IleArgCysAspSerProAspHisLeuPro-445 464-AlaLeuAspLysAsnTyrArgIleAspThrProCys-475 487-HisGlyThrArgGlyLeuAla-493 511-HisProPheSerGlnArgLeuArgHisAlaLeuHisProAsnArgThrIle-527 531-IleValArgArgLysAspLeuThrPro-539 Hydrophilic Regions - Hopp-Woods 10-ProAspIleArgThrLeuAspGlnAlaIleArgLysHisAlaPro-24 44-GlnAspAlaSerAspAlaGluCysArgLeuLysHisArgLeuAspGln-59 105-AlaIleProGlnThrGluSerLysProAspLys-115 122-GlnThrSerGluArgGlnLysProGluHis-131 158-LeuGluAlaArgLysAlaAlaGln-165 180-SerProHisAspThrGluGlnThrGlu-188 206-ProGluSerGluThr-210 222-SerArgThrGluGlnGlnArgAsnHisGlu-231 246-ThrSerAlaGluAlaGluLysIleAla-254 294-LeuHisGluAspThrProLeu-300 303-IleSerHisAspGlyGluLysTrpIle-311 346-ArgGlnIleArgGly-350 398-AsnGluAlaGluGluAlaSerAsnArgGlnAla-408 426-AsnProGlnLysHisGlnGly-432 436-IleArgCysAspSerProAsp-442 467-LysAsnTyrArgIleAspThr-473 515-GlnArgLeuArgHis-519 531-IleValArgArgLysAspLeuThrPro-539 214-1 AMPHI Regions - AMPHI 6-CysLysLeuPheValLeuIle-12 69-ValThrArgGlyGlyLysGlyGlyGluSerVal-79 88-PheSerGlnThrLeuAsp-93 122-LysValGlnArgGlyGlyAspVal-129 150-ThrLysSerGlyAlaLysSerAlaSerLys-159 Antigenic Index - Jameson-Wolf 23-LeuGlnSerAspSerArgGlnProIle-31 33-IleGluAlaAspGlnGlySerLeuAspGlnAlaAsnGlnSerThrThrPheSerGlyAsn-52 71-ArgGlyGlyLysGlyGlyGluSerValArgAlaGluGlySerProValArgPheSerGlnThrLeuAspGlyG lyLysGlyThrValArgGlyGlnAlaAsnAsn-105 119-GlyAsnAlaLysValGlnArgGlyGlyAspValAlaGlu-131 137-TyrAsnThrLysThrGluVal-143 148-GlySerThrLysSerGlyAlaLysSerAlaSerLysSerGlyArgValSerVal-165 168-GlnProSerSerThrGlnLysSerGlu-176 Hydrophilic Regions - Hopp-Woods 25-SerAspSerArgGlnProIle-31 33-IleGluAlaAspGlnGlySerLeuAspGlnAlaAsn-44 71-ArgGlyGlyLysGlyGlyGluSerValArgAlaGluGlySerPro-85 92-LeuAspGlyGlyLysGlyThrValArgGlyGlnAla-103 121-AlaLysValGlnArgGlyGlyAspValAlaGlu-131 148-GlySerThrLysSerGlyAlaLysSerAlaSerLysSerGlyArg-162 171-SerThrGlnLysSerGlu-176 215-2 AMPHI Regions - AMPHI 21-SerLeuSerAlaTrpLeuGlyArgIle-29 67-SerAlaLysGlyAlaLysGlnPheProGlu-76 Antigenic Index - Jameson-Wolf 3-ValArgTrpArgTyrGly-8 28-ArgIleSerGluValGluIleGluGluValArgLeuAsnProAspGluProGlnTyrThrMetAspGlyLeuA ΞpGlyArgArgPheAspGluGlnGlyTyrLeuLys-63 65-HisLeuSerAlaLysGlyAlaLysGlnPheProGluSerSerAspIleHisPheAspSerProHisLeu-87 99-ValGlySerAspGluAlaValTyrHisThrGluAsnLysGlnValLeuPhe-115 123-LysThrAlaAspGlyLysArgGlnAlaGlyLysValGluAlaGluLysLeuHisValAspThrGluSerGln TyrAlaGlnThrAspThrProVal-154 160-AlaSerHisGlyGlnAlaGlyGlyMetThrTyrAspHisLysThrGly-175 179-PheSerSerLysValLys-184 187-11eTyrAspThrLysAspMet-193 Hydrophilic Regions - Hopp-Woods 29-IleSerGluValGluIleGluGluValArgLeuAsnProAspGluProGlnTyr-46 49-AspGlyLeuAspGlyArgArgPheAspGlu-58 65-HisLeuSerAlaLysGlyAlaLysGlnPheProGluSerSerAspIleHisPhe-82 99-ValGlySerAspGluAlaValTyr-106 108-ThrGluAsnLysGlnValLeu-114 123-LysThrAlaAspGlyLysArgGlnAlaGlyLysValGluAlaGluLysLeuHisValAspThrGluSerGln TyrAla-148 170-TyrAspHisLysThr-174 187-IleTyrAspThrLysAspMet-193 216-2 AMPHI Regions - AMPHI 6-LysTyrLeuAspTrpAlaArg-12 19-AlaGluGlyLeuArgGluIleAlaAlaGluLeu-29 60-ArgLysMetAlaAla-64 165-LeuGlyAspAlaLeuAlaVal-171 201-ValAlaAspIleMetHis-206 216-LeuGlyThrProLeuLysGlu-222 242-GlyArgLeuLysGlyVal-247 251-GlyAspLeuArgArgLeuPheGlnGluCysAspAsnPheThrGlyLeuSerIle-268 272-MetHisThrHisProLysThrIleSerAla-281 290-LysValMetGlnAlaAsn-295 Antigenic Index - Jameson-Wolf l-MetAlaGluAsnGlyLysTyr-7 14-ValLeuHisAlaGluAlaGluGlyLeuArgGluIleAlaAlaGluLeuAspLysAsnPhe-33 43-CysLysGlyArgVal-47 51-GlyMetGlyLysSerGlyHisIleGlyArgLysMetAla-63 80-GluAlaAlaHisGlyAspLeu-86 90-ValAspAsnAspVal-94 99-SerAsnSerGlyGluSerAspGluIle-107 113-AlaLeuLysArgLysAspIle-119 125-ThrAlaArgProAspSerThrMetAlaArgHisAlaAsp-137 144-ValSerLysGluAlaCysPro-150 177-ArgAlaPheThrProAspAspPheAla-185 188-HisProAlaGlySerLeuGlyLys-195 203-AspIleMetHisLysGlyGlyGlyLeuProAla-213 216-LeuGlyThrProLeuLysGluAlaIle-224 227-MetSerGluLysGlyLeu-232 237-ValThrAspGlyGlnGlyArgLeuLysGly-246 248-PheThrAspGlyAspLeuArgArgLeuPheGlnGluCysAspAsnPheThr-264 275-HisProLysThrIleSerAlaGluArgLeuAlaThrGluAlaLeuLys-290 303 -ThrAspAlaAspGly-307 Hydrophilic Regions - Hopp-Woods l-MetAlaGluAsnGlyLys-6 14-ValLeuHisAlaGluAlaGluGlyLeuArgGluIleAlaAlaGluLeuAspLys-31 43-CysLysGlyArgVal-47 56-GlyHisIleGlyArgLysMetAla-63 100-AsnSerGlyGluSerAspGluIle-107 113-AlaLeuLysArgLysAspIle-119 126-AlaArgProAspSerThrMetAlaArgHisAlaAsp-137 144-ValSerLysGluAlaCys-149 177-ArgAlaPheThrProAspAspPheAla-185 218-ThrProLeuLysGluAlaIle-224 227-MetSerGluLysGlyLeu-232 239-AspGlyGlnGlyArgLeuLys-245 251-GlyAspLeuArgArgLeuPheGlnGluCysAspAsn-262 277-LysThrIleSerAlaGluArgLeuAlaThrGluAlaLeuLys-290 303 -ThrAspAlaAspGly-307 218-2 AMPHI Regions - AMPHI 37-LeuLeuAlaValThr-41 121-AlaLysValValSerThrMet-127 136-ThrMetAspGluIleHisSer-142 190-AlaArgSerTrpTrpArgAsnLeuHisGlyThrPheGlyThrTrpValSerLeuIleLeu-209 223-TrpGlyGlyLysPheValGlnAlaTrpSerGlnPhePro-235 288-AspGluProMetThrLeuGluThrValAspArgPheAlaArgGlu-302 359-TyrAsnProPheGlyLysPheMet-366 377-LeuGlyTrpTrpSerValLeuAlaAsn-385 Antigenic Index - Jameson-WoIf 3-ThrGlnIleLysThrGluAlaAspAsnGlnSerAsnArgArgTyrLeu-18 51-IleThrGlyLysGluGlyGluArgIleHis-60 74-AlaGluAlaAlaArgSerAlaValAsnProGluThrSerSer-87 94-ProArgAlaAspAspMet-99 105-ValAsnAsnGluGlyLysAla-lll 125-SerThrMetProArgAsnGlnGlyTrp-133 174-ValLysArgArgGlyIleLysAla-181 183-LeuLeuProSerLysGlyArgAlaArgSerTrpTrp-194 196-AsnLeuHisGlyThrPheGly-202 235-ProAlaGlyLysTrpGlyValGluProAsnProVal-246 255-ValLeuAsnAspGlyLysValLysGlu-263 279-ThrValGlyLysAspGlyIleAsnProAspGluProMetThr-292 294-GluThrValAspArgPheAlaArg-301 303-IleGlyPheLysGlyArgTyrGlnLeuAsnLeuProLysGlyGluAspGly-319 323-LeuSerGlnAspSerMetSerTyr-330 336-PheAlaAspArgThrValHis-342 344-AspGlnTyrSerGlyLysIleLeuAla-352 354-IleArgPheAspAspTyrAsnProPhe-362 404-TrpLysArgArgProThrGlyAla-411 417-ProAlaGlnLysValLysLeu-423 Hydrophilic Regions - Hopp-Woods 3-ThrGlnIleLysThrGluAlaAspAsnGlnSerAsnArgArgTyr-17 52-ThrGlyLysGluGlyGluArgIleHis-60 74-AlaGluAlaAlaArgSerAlaValAsnProGluThrSerSer-87 94-ProArgAlaAspAspMet-99 105-ValAsnAsnGluGlyLysAla-lll 175-LysArgArgGlyIleLys-180 186-SerLysGlyArgAla-190 255-ValLeuAsnAspGlyLysValLysGlu-263 279-ThrValGlyLysAspGlyIleAsnProAspGluProMetThr-292 294-GluThrValAspArgPheAlaArg-301 314-ProLysGlyGluAspGly-319 325GlnAspSerMetSer-329 336-PheAlaAspArgThrValHis-342 354-11eArgPheAspAsp-358 405-LysArgArgProThrGly-410 219-2 (included in 218, so delete this one) AMPHI Regions - AMPHI 37-LeuLeuAlaValThr-41 121-AlaLysValValSerThrMet-127 136-ThrMetAspGluIleHisSer-142 190-AlaArgSerTrpTrpArgAsnLeuHisGlyThrPheGlyThrTrpValSerLeuIleLeu-209 223-TrpGlyGlyLysPheValGlnAlaTrpSerGlnPhePro-235 288-AspGluProMetThrLeuGluThrValAspArgPheAlaArgGlu-302 359-TyrAsnProPheGlyLysPheMet-366 377-LeuGlyTrpTrpSerValLeuAlaAsn-385 Antigenic Index - Jameson-Wolf 3-ThrGlnIleLysThrGluAlaAspAsnGlnSerAsnArgArgTyrLeu-18 51-IleThrGlyLysGluGlyGluArgIleHis-60 74-AlaGluAlaAlaArgSerAlaValAsnProGluThrSerSer-87 94-ProArgAlaAspAspMet-99 105-ValAsnAsnGluGlyLysAla-lll 125-SerThrMetProArgAsnGlnGlyTrp-133 174-ValLysArgArgGlyIleLysAla-181 183-LeuLeuProSerLysGlyArgAlaArgSerTrpTrp-194 196-AsnLeuHisGlyThrPheGly-202 235-ProAlaGlyLysTrpGlyValGluProAsnProVal-246 255-ValLeuAsnAspGlyLysValLysGlu-263 279-ThrValGlyLysAspGlyIleAsnProAspGluProMetThr-292 294-GluThrValAspArgPheAlaArg-301 303-IleGlyPheLysGlyArgTyrGlnLeuAsnLeuProLysGlyGluAspGly-319 323-LeuSerGlnAspSerMetSerTyr-330 336-PheAlaAspArgThrValHis-342 344-AspGlnTyrSerGlyLysIleLeuAla-352 354-IleArgPheAspAspTyrAsnProPhe-362 404-TrpLysArgArgProThrGlyAla-411 417-ProAlaGlnLysValLysLeu-423 Hydrophilic Regions - Hopp-Woods 3-ThrGlnIleLysThrGluAlaAspAsnGlnSerAsnArgArgTyr-17 52-ThrGlyLysGluGlyGluArgIleHis-60 74-AlaGluAlaAlaArgSerAlaValAsnProGluThrSerSer-87 94ProArgAlaAspAspMet-99 105-ValAsnAsnGluGlyLysAla-lll 175-LysArgArgGlyIleLys-180 186-SerLysGlyArgAla-190 255-ValLeuAsnAspGlyLysValLysGlu-263 279-ThrValGlyLysAspGlyIleAsnProAspGluProMetThr-292 294-GluThrValAspArgPheAlaArg-301 314-ProLysGlyGluAspGly-319 325-GlnAspSerMetSer-329 336-PheAlaAspArgThrValHis-342 354-IleArgPheAspAsp-358 405-LysArgArgProThrGly-410 225-1 AMPHI Regions - AMPHI 23-LeuAlaAspGluLeuThrAsn-29 37-IleLeuArgGlnPhe-41 126-AsnAlaMetGlyLeu-130 151-PheMetGlnHisIlePheLys-157 217-ThrGlyLysAsnIle-221 Antigenic Index - Jameson-Wolf 22-AlaLeuAlaAspGluLeuThr-28 32-SerSerArgGluGlnIleLeu-38 41-PheAlaGluAspGluGlnProVal-48 52-AsnArgAlaProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-66 71-GlyLeuAsnGluGlnProVal-77 81-AsnArgValProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-95 100-GlyLeuAsnGluGlnProVal-106 108-ProValAsnArgAlaProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-124 144-ThrGlyPheAspCysSerGly-150 164-LeuProArgThrSerAlaGluGlnAlaArgMet-174 176-ThrProValAlaArgSerGluLeuGlnProGlyAsp-187 194-LeuGlyGlySerArgIle-199 213-HisAlaProArgThrGlyLysAsnIleGlu-222 225-SerLeuSerHisLysTyrTrpSerGlyLys-234 239-ArgArgValLysLysAsnAspProSerArgPhe-249 Hydrophilic Regions - Hopp-Woods 22-AlaLeuAlaAspGluLeuThr-28 32-SerSerArgGluGlnIleLeu-38 41-PheAlaGluAspGluGlnPro-47 53-ArgAlaProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-66 83-ValProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-95 lll-ArgAlaProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-124 166-ArgThrSerAlaGluGlnAlaArgMet-174 178-ValAlaArgSerGluLeuGlnPro-185 216-ArgThrGlyLysAsnIleGlu-222 239-ArgArgValLysLysAsnAspProSerArg-248 226 AMPHI Regions - AMPHI 44-LeuIleAlaTyrLeuLys-49 61-AlaAlaGlnPheIleAspPheTrpLeu-69 98-GlnLeuAlaGlySerValThrGlyIleValThr-108 141-ArgSerIleGlyGlyIleProAlaIleThr-150 157-AlaGlyLeuValGlyGlnIleAlaGlyTyrLys-167 197-GluArgSerArgArg-201 Antigenic Index - Jameson-Wolf 3-GlulleLeuArgGlnProSer-9 25-ValArgThrArgThrGlyAsnIle-32 81-TyrGlnAsnArgArgLysIle-87 117-GlyAlaGluArgGluVal-122 128-SerLysSerValThrAsn-133 139-IleThrArgSerIleGlyGly-145 167-LysMetLeuLysAsnThrVal-173 195-SerLeuGluArgSerArgArgMetAla-203 Hydrophilic Regions - Hopp-Woods 25-Va1ArgThrArgThr-29 82-GlnAsnArgArgLysIle-87 117-GlyAlaGluArgGluVal-122 195-SerLeuGluArgSerArgArgMetAla-203 227-2 AMPHI Regions - AMPHI 36-GlyValLeuPheAlaLeuLeuGlnAla-44 52-LeuGlnGlnLeuThrAspAlaLeu-59 74-ValIleSerTyrLeuAspLeuIleAlaAspAspTrpPheSer-87 228 AMPHI Regions - AMPHI 24-GluValLysGluAlaValGlnAlaValGlu-33 40-AlaAlaSerAlaAlaGluSerAlaAlaSerAlaValGluGluAlaLysAspGlnValLysAspAla-61 78-GluAlaValThrGluAlaAlaLysAspThrLeuAsnLysAlaAlaAspAlaThrGlnGluAlaAlaAspLysM etLysAspAlaAla-106 Antigenic Index - Jameson-Wolf 18-SerGlnGluAlaLysGlnGluValLysGluAlaValGln-30 32-ValGluSerAspValLysAspThrAlaAlaSerAlaAlaGluSerAlaAlaSerAlaValGluGluAlaLysA spGlnValLysAspAlaAlaAlaAspAlaLysAlaSerAlaGluGluAlaValThrGluAlaLysGluAlaValTh rGluAlaAlaLysAspThrLeuAsnLysAlaAlaAspAlaThrGlnGluAlaAlaAspLysMetLysAspAlaAla Lys-107 Hydrophilic Regions - Hopp-Woods 18-SerGlnGluAlaLysGlnGluValLysGluAlaValGln-30 32-ValGluSerAspValLysAspThrAlaAlaSerAlaAlaGluSerAlaAlaSerAlaValGluGluAlaLysA spGlnValLysAspAlaAlaAlaAspAlaLysAlaSerAlaGluGluAlaValThrGluAlaLysGluAlaValTh rGluAlaAlaLysAspThrLeuAsnLysAlaAlaAspAlaThrGlnGluAlaAlaAspLysMetLysAspAlaAla Lys-107 230-1 AMPHI Regions - AMPHI 6-GluLysTyrArgThr-10 49-AspHisSerIleAsnAsn-54 56-IleGlnAsnGluGln-60 73-GlnSerLeuLeuGln-77 81-LeuLysGlnGlyAlaLys-86 96-GlnIleLysGlnIleIle-101 133-PheValGluGluIleArgAspGlnPhe-141 144-GlnAsnLeuValAsnLeuVal-150 161-AlaGluGlnLeuIleArgLeuThrGlnValAsnArgThrIleArg-175 184-PheIleAlaGlnVal-188 194-AspLeuGlnLysPheTyrAsn-200 234-GluValLysAsnAlaPheGluGluArgValAlaArgLeu-246 272-ValAlaAspPheAsnLys-277 284-AspAspAlaPheAsnHisProSerSerLeuAlaGluAla-296 319-SerGlyMetProGluAsnLeuIleAsnAlaVal-329 398-LeuAsnGlyGlyLys-402 426-GluAlaTyrAlaGluLeu-431 444-ValArgLeuIleGlyLeuProAlaPro-452 456-GluValGlnAlaValThrProProAspAspIleAla-467 488-LeuLeuIleArgTyrPheAsn-494 Antigenic Index - Jameson-WoIf 4-SerIleGluLysTyrArgThrProAla-12 32-SerHisProGlyAlaAsp-37 42-ValGlyAspGluLysIleSerAspHisSerIle-52 56-IleGlnAsnGluGlnAlaAspGlyGlyGlyProSerArgAspAlaVal-71 80-TyrLeuLysGlnGlyAla-85 92-ValSerSerGluGlnIleLys-98 101-IleValAspAspProAsnPheHisAspAlaAsnGlyLysPheAsp-115 122-TyrLeuSerGlnArgHisMetSerGluAspGlnPheValGluGluIleArgAsp-139 169-GlnValAsnArgThrIleArgSerHisThrPheAsnProAspGluPhe-184 189-LysValSerGluAlaAspLeu-195 199-TyrAsnAlaAsnLysLysAspTyrLeu-207 223-AspPheAlaAspLysGlnThrValSerGluThrGluValLysAsnAlaPheGluGluArgValAlaArg-24 5 247-ProAlaAsnGluAlaLysProSerPheGluGlnGluLysAlaAlaValGluAsnGluLeuLysMetLysLys AlaValAlaAspPheAsnLysAlaLysGluLysLeuGlyAspAspAlaPheAsnHisProSerSerLeuAlaGluA laAlaLysAsnSerGlyLeuLysValGluThrGlnGluThrTrpLeuSerArgGlnAspAlaGlnMetSerGlyMe tProGluAsn-324 330-PheSerAspAspValLeuLysLysLysHisAsnSerGlu-342 355-ArgAlaLysGluValArgGluGluLysThrLeuPro-366 368-AlaGluAlaLysAspAlaValArg-375 377-AlaTyrIleArgThrGluAlaAlaLysLeuAlaGluAsnLysAlaLysAspValLeu-395 399-AsnGlyGlyLysAlaValAsp-405 417-GlnGlnAlaArgGlnSerMetProProGluAlaTyr-428 432-LeuLysAlaLysProAlaAsnGlyLysProAla-442 459-AlaValThrProProAspAspIleAla-467 476-AlaLeuAlaGlnGlnGlnSerAlaAsnThrPhe-486 493-PheAsnGlyLysIleLysGlnThrLysGlyAlaGlnSerValAspAsnGlyAspGlyGln-512 Hydrophilic Regions - Hopp-Woods 6-GluLysTyrArgThr-10 42-ValGlyAspGluLysIleSerAsp-49 56-IleGlnAsnGluGlnAlaAspGlyGlyGlyProSerArgAspAlaVal-71 92-ValSerSerGluGlnIleLys-98 101-IleValAspAspProAsnPhe-107 110-AlaAsnGlyLysPheAsp-115 126-ArgHisMetSerGluAspGlnPheValGluGluIleArgAsp-139 189-LysValSerGluAlaAspLeu-195 200-AsnAlaAsnLysLysAspTyrLeu-207 223-AspPheAlaAspLysGlnThrValSerGluThrGluValLysAsnAlaPheGluGluArgValAlaArg-24 5 247-ProAlaAsnGluAlaLysProSerPheGluGlnGluLysAlaAlaValGluAsnGluLeuLysMetLysLys AlaValAlaAspPheAsnLysAlaLysGluLysLeuGlyAspAspAlaPhe-287 292-SerLeuAlaGluAlaAlaLysAsnSerGlyLeuLysValGluThrGlnGlu-308 310-TrpLeuSerArgGlnAspAlaGlnMet-318 333-AspValLeuLysLysLysHisAsnSer-341 355-ArgAlaLysGluValArgGluGluLysThrLeuPro-366 368-AlaGluAlaLysAspAlaValArg-375 377-AlaTyrIleArgThrGluAlaAlaLysLeuAlaGluAsnLysAlaLysAspValLeu-395 417-GlnGlnAlaArgGlnSerMetPro-424 432-LeuLysAlaLysProAlaAsnGly-439 461-ThrProProAspAspIleAla-467 496-LysIleLysGlnThrLysGlyAlaGlnSerValAspAsnGlyAspGlyGln-512 231-1 AMPHI Regions - AMPHI 7-IleAsnArgProTyrGlnLysProAlaGluLeu-17 98-ArgIlePheSerPheProGln-104 209-AlaValAspAsnValLysGlyValAlaVal-218 228-AlaValAlaGlyPheArgArgCysSerAlaAla-238 263-LeuAlaAlaValProArgIleThrGln-271 281-LysProPheHisAspPhePheAsnLeu-289 Antigenic Index - Jameson-Wolf l-MetSerLysArgLysSerIleAsnArgProTyrGlnLysProAlaGlu-16 18-ProProLeuGlnAsnAsnProProPheTyrArgLysAsnArgArgLeuAsn-34 39-AlaAspGlyGlyCysAlaSerProGlnLysCysArgAlaArgGlyPheGln-55 90-SerAlaValArgProArgArgLeuArg-98 135-MetProArgArgProVal-140 150-PheAlaAspArgAsnLeuArg-156 174-AlaPheArgArgArgAlaGlnVal-181 183-AlaArgThrArgAla-187 194-ArgArgValAspIleArgHisProAspPhe-203 211-AspAsnValLysGly-215 231-GlyPheArgArgCysSerAlaAlaGlyGlyArgValGlyThr-244 246-ValProCysArgAlaGluTyrValGluTyrGlyAsnArgArgProHisArgLeuAlaAla-265 269-IleThrGlnArgThrGlnLysArgGlnGlyAspGlyLysProPhe-283 294-MetProMetProSerGluHis Hydrophilic Regions - Hopp-Woods l-MetSerLysArgLysSerIleAsn-8 10-ProTyrGlnLysProAlaGlu-16 26-PheTyrArgLysAsnArgArg-32 45-SerProGlnLysCysArgAlaArgGly-53 92-ValArgProArgArgLeuArg-98 136-ProArgArgProVal-140 150-PheAlaAspArgAsnLeuArg-156 174-AlaPheArgArgArgAlaGlnVal-181 183-AlaArgThrArgAla-187 194-ArgArgValAspIleArgHis-200 231-GlyPheArgArgCysSerAlaAlaGlyGlyArgValGlyThr-244 246-ValProCysArgAlaGluTyr-252 254-GluTyrGlyAsnArgArgProHisArg-262 269-IleThrGlnArgThrGlnLysArgGlnGlyAspGlyLysProPhe-283 232-2 AMPHI Regions - AMPHI 23-GlnPheLeuGlyAlaPheAsnAspAsnVal-32 55-GlyGlnMetLeuAsn-59 74-SerLeuSerGlyGlnLeuGlyAsnLysPheAspLysAlaValLeuAlaArgTrpValLysValLeuGluMetI leIleMet-100 127-ThrLeuPheGlyProLeuLysTyr-134 160-AlaIleLeuPheGly-164 167-LeuGlyThrAlaValAlaGlyValProProTyrIleValGlyIleLeuVal-183 214-ValArgGlyThrLysSerLeuLeuArgGlu-223 251-LeuProThrPheThrGln-256 319- rgPheGluGlyLeuAsn-324 340-AlaValMetThrLeuIleGlyPhePheGlyGlyPhePheSerValProLeuTyrThrTrpLeu-360 Antigenic Index - Jameson-Wolf l-MetTyrAlaLysLysGlyGlyLeuGlyLeuValLysSerArgArgPhe-16 75-LeuSerGlyGlnLeuGlyAsnLysPheAspLys-85 139-AspTyrLeuAspAspLysGluLeuMetMet-148 200-ValProAlaLysAlaAlaAspThrGlnIle-209 215-ArgGlyThrLysSerLeuLeuArgGluThrValArgHisLysPro-229 258-HisLeuGlyGlyAsnAspAsnVal-265 286-LysPheSerArgGluArgLeu-292 316-HisGlyHisArgPheGluGly-322 363-AlaSerSerGluThrPheArgAlaArgAla-372 420-IleLyεArgGluArgArgPheLeu-427 431-AlaIleArgLysLysPro-436 Hydrophilic Regions - Hopp-Woods 2-TyrAlaLysLysGlyGly-7 H-ValLysSerArgArgPhe-16 81-AsnLysPheAspLys-85 140-TyrLeuAspAspLysGluLeuMet-147 201-ProAlaLysAlaAlaAspThrGlnIle-209 215-ArgGlyThrLysSerLeuLeuArgGluThrValArgHis-227 286-LysPheSerArgGluArgLeu-292 318-HisArgPheGluGly-322 366-GluThrPheArgAlaArgAla-372 420-IleLysArgGluArgArgPheLeu-427 431-AlaIleArgLysLysPro-436 233-2 AMPHI Regions - AMPHI 61-PheAlaAspLysValGlnThr-67 71-GlnValArgValTrpLysAsn-77 88-AsnGlyValAlaLysLeuLeuGluThr-96 119-AlaLeuThrArgLeuIleGluGlnAlaGlyAsnAla-130 138-IleProIleAlaAspThrLeuLysCysAlaAspGlyGlyAsn-151 180-AlaAlaGluAsnLeuAspGlyIleThrAsp-189 Antigenic Index - Jameson-Wolf l-MetLysArgLysAsnIle-6 16-AlaArgPheGlyAlaAspLysProLysGlnTyrValGluIleGlySerLysThrValLeu-35 43-GluArgHisGluAlaValAsp-49 56-SerProGluAspThrPheAlaAspLysValGln-66 75-TrpLysAsnGlyGlyGlnThrArgAlaGluThrValArgAsnGlyVal-90 100-AlaGluThrAspAsn-104 109-AspAlaAlaArgCys-113 115-LeuProSerGluAlaLeu-120 123-LeuIleGluGlnAlaGlyAsnAlaAlaGluGlyGly-134 142-AspThrLeuLysCysAlaAspGlyGlyAsnIle-152 155-ThrValGluArgThrSerLeu-161 182-GluAsnLeuAspGlyIleThrAspGluAlaSerAlaValGluLysLeuGlyVal-199 206-GlyAspValArgAsnLeuLysLeuThrGlnProGlnAspAlaTyr-220 Hydrophilic Regions - Hopp-Woods l-Me LysArgLysAsnIle-6 18-PheGlyAlaAspLysProLysGlnTyrVal-27 43-GluArgHisGluAlaValAsp-49 56-SerProGluAspThrPheAlaAspLysValGln-66 79-GlyGlnThrArgAlaGluThrValArg-87 100-AlaGluThrAspAsn-104 127-AlaGlyAsnAlaAlaGlu-132 142-AspThrLeuLysCysAlaAsp-148 182-GluAsnLeuAspGlyIleThrAspGluAlaSerAlaValGluLysLeuGlyVal-199 206-GlyAspValArgAsnLeuLys-212 234-2 AMPHI Regions - AMPHI 26-ArgSerLeuGluValGluLysValAlaSer-35 68-AspArgLeuGlySerGln-73 83-GlnGlnThrAsnArgPheAsnValLeuAsnArgThrAsn-95 121-GlyAspValThrGluPhe-126 206-AlaValAsnSerLeuValGlnAlaValAsp-215 Antigenic Index - Jameson-Wolf 21-AlaThrGluSerSerArgSerLeuGluValGluLysValAlaSer-35 51-ThrPheAspAsnArgSerSerPhe-58 62-IlePheSerAspGlyGluAspArgLeuGlySerGlnAla-74 83-GlnGlnThrAsnArgPheAsnValLeuAsnArgThrAsn-95 99-LeuLysGlnGluSerGlyIleSerGlyLysAlaHisAsnLeuLysGlyAlaAspTyr-117 121-GlyAspValThrGluPheGlyArgArgAspValGlyAsp-133 140-LeuGlyArgGlyLysSerGlnIle-147 160-AsnThrSerGluIle-164 169-GlnGlyAlaGlyGlu-173 175-AlaLeuSerAsnArgGluIle-181 185-GlyGlyThrSerGlyTyrAspAlaThrLeuAsnGlyLysValLeu-199 214-ValAspAsnGlyAlaTrpGlnProAsnArg-223 Hydrophilic Regions - Hopp-Woods 21-AlaThrGluSerSerArgSerLeuGluValGluLysValAla-34 52-PheAspAsnArgSerSerPhe-58 62-IlePheSerAspGlyGluAspArgLeuGlySerGlnAla-74 99-LeuLysGlnGluSerGlyIleSerGlyLysAlaHisAsn-lll 122-AspValThrGluPheGlyArgArgAspValGlyAsp-133 141-GlyArgGlyLysSer-145 176-LeuSerAsnArgGluIle-181 235 AMPHI Regions - AMPHI 8-LeuAlaAlaValLeuAlaLeu-14 18-GlnValGlnLysAlaProAsp-24 86-LeuThrAsnAlaAlaAspIle-92 95-ValArgProGluLysLeuHisGlnIlePhe-104 120-SerTyrGlnIleLeuAspSerValThrThr-129 165-GlyAlaLeuValSerAlaValValAsnGlnIleAlaAsnSerLeuThr-180 187-SerLysThrAlaAlaTyrAsnLeuLeuSerProTyr-198 Antigenic Index - Jameson-Wolf 20-GlnLysAlaProAspPheAspTyrThrSerPheLysGluSerLysProAla-36 43-ProLeuAsnGluSerProAspValAsnGlyThr-53 62-AlaProLeuSerGlu-66 79-GluThrPheLysGlnAsnGlyLeuThrAsn-88 93-HisAlaValArgProGluLysLeu-100 131-ΞerAlaLysAlaArgLeuValAspSerArgAsnGlyLysGluLeuTrpSerGlySerAlaSerIleArgGlu GlySerAsnAsnSerAsnSer-161 178-SerLeuThrAspArgGlyTyrGlnValSerLysThrAla-190 202-GlyIleLeuLysGlyProArgPheValGluGluGlnProLys-215 Hydrophilic Regions - Hopp-Woods 20-GlnLysAlaProAspPheAsp-26 29-SerPheLysGluSerLysPro-35 44-LeuAsnGluSerProAspVal-50 93-HisAlaValArgProGluLysLeu-100 131-SerAlaLysAlaArgLeuValAspSerArgAsnGlyLysGluLeuTrp-146 150-AlaSerIleArgGluGlySerAsnAsnSer-159 179-LeuThrAspArgGlyTyrGln-185 207-ProArgPheValGluGluGlnProLys-215 236-2 AMPHI Regions - AMPHI ll-LeuCysThrAlaPheAlaAsp-17 107-PheAlaGlyPheAlaAspCysArgProPhe-116 146-AspAspValProArgPhePheAlaGlyGlu-155 178-AlaAlaCysMetAlaValCysPheGly-186 214-LysValGluGlyIleThrArgIle-221 245-IleArgLeuLeuHisGlyIlePheAsnArgIleLysValAla-258 288-PheAlaAlaValIle-292 311-LeuArgCysAsnAspValAlaAspGlyPheArgHisPhe-323 Antigenic Index - Jameson-Wolf 42-GlyPheSerGlyAsnGlyLysPhe-49 58-ArgHisGlnGlnSerLysAlaGln-65 77-PhePheArgArgGlyAsnPheGlyPheGlyLeuGlnGlyArgThrAspGlyPhe-94 98-GlnArgLeuAspGlyGlyGlyTyr-105 109-GlyPheAlaAspCysArgProPhe-116 126-ValAspGlyArgGluLeuValProSerMetGluGluAspAla-139 145-AlaAspAspValPro-149 155-GluAlaGlnAsnArgCysAsnGlnGluAsnGlnThrAla-167 195-ValGluValGluArgThrGlnValPheArgAlaGluArgAsnAsnValPhe-211 213-GlyLysValGluGlyIleThr-219 261-GlyLysGlnLysAlaGlnGly-267 292-IleGlyArgCysArgProGlnAlaGln-300 312-ArgCysAsnAspValAlaAspGly-319 328-ValAspAsnGluThrMet-333 Hydrophilic Regions - Hopp-Woods 89-GlyArgThrAspGly-93 98-GlnArgLeuAspGlyGlyGly-104 127-AspGlyArgGluLeuValProSerMetGluGluAspAla-139 145-AlaAspAspValPro-149 156-AlaGlnAsnArgCysAsnGlnGluAsnGlnThr-166 195-ValGluValGluArgThrGlnValPheArgAlaGluArgAsnAsn-209 215-ValGluGlyIleThr-219 261-GlyLysGlnLysAlaGlnGly-267 293-GlyArgCysArgProGlnAlaGln-300 312-ArgCysAsnAspValAlaAspGly-319 328-ValAspAsnGluThrMet-333 238 AMPHI Regions - AMPHI 103-ValHisSerProPhe-107 112-SerLysSerThrSerAspPheSerGlyGlyVal-122 129-TyrGlnLeuHisArgThrGlySer-136 141-GluAspGlyTyrAspGlyProGlnGlySer-150 158-AlaArgAspIleTyrSerTyrTyrVal-166 224-AspAspValArgGlyIleValGlnGlyAlaValAsnPro-236 246-IleGlyAlaIleThrAspSerAlaValSerProValThrAspThrAlaAlaGlnGlnThrLeuGlnGlyIle AsnAspLeuGlyLysLeu-275 298-IleAsnSerAlaLysGlnTrpAlaAspAla-307 342-AspTrpValLysAsn-346 351-LysProAlaAlaArgHisMetGlnThrLeu-360 367-GlyAsnLysProIleLysSerLeuProAsn-376 398-PheAspSerValHisLysThrLeuThr-406 465-GlyLysGlnAlaLysAspTyrLeu-472 Antigenic Index - Jameson-Wolf 25-HisAlaAsnGlyLeuAspAlaArgLeuArgAspAspMetGlnAlaLysHisTyrGluProGlyGlyLys-47 53-AsnAlaArgGlySerValLysLysArgValTyr-63 80-ThrHisGluArgThrGlyPheGluGly-88 96-PheSerGlyHisGlyHisGluValHisSerProPheAspHisHisAspSerLysSerThrSerAspPheSerG lyGlyValAspGlyGly-125 131-LeuHisArgThrGlySerGluIleHisProGluAspGlyTyrAspGlyProGlnGlySerAspTyrProPro ProGlyGlyAlaArgAsp-160 166-ValLysGlyThrSerThrLysThrLysThr-175 182-ProPheSerAspArgTrpLeuLysGluAsnAlaGlyAla-194 200-SerArgAlaAspGluAlaGly-206 210-TrpGluSerAspProAsnLysAsnTrp-218 221-AsnArgMetAspAspValArgGlyIle-229 268-GlyIleAsnAspLeuGlyLysLeuSerProGluAlaGln-280 292-PheAlaValLysAspGlyIleAsnSerAlaLysGlnTrpAla-305 307-AlaHisProAsnIle-311 329-TrpArgGlyLysLysValGluLeuAsnProThrLysTrpAspTrpValLysAsnThrGlyTyrLysLysPro AlaAlaArg-355 360-LeuAspGlyGluMetAlaGlyGlyAsnLysProIleLysSerLeuProAsnSerAlaAlaGluLysArgLys GlnAsnPheGluLysPheAsnSerAsnTrpSer-394 396-AlaSerPheAspSerValHisLysThrLeuThrProAsnAla-409 413-LeuSerProAspLysValLysThrArgTyrThrSerLeuAspGlyLysIleThrIleIleLysAspAsnGlu AsnAsnTyr-439 441-ArgIleHisAspAsnSerArgLysGlnTyrLeuAspSerAsnGlyAsnAlaValLysThrGlyAsnLeuGln GlyLysGlnAlaLysAspTyrLeuGln-473 476-ThrHisIleArgAsnLeuAspLys-483 Hydrophilic Regions - Hopp-Woods 29-LeuAspAlaArgLeuArgAspAspMetGlnAlaLysHisTyrGluProGlyGly-46 54-AlaArgGlySerValLysLysArgValTyr-63 80-ThrHisGluArgThrGlyPhe-86 108-AspHisHisAspSerLysSerThrSerAspPhe-118 133-ArgThrGlySerGluIleHisProGluAspGlyTyrAspGlyProGlnGlySerAspTyrProPro-154 156-GlyGlyAlaArgAsp-160 169-ThrSerThrLysThrLysThr-175 186-ArgTrpLeuLysGluAsnAlaGly-193 200-SerArgAlaAspGluAlaGly-206 222-ArgMetAspAspValArgGly-228 271-AspLeuGlyLysLeuSerPro-277 296-AspGlyIleAsnSer-300 329-TrpArgGlyLysLysValGluLeuAsnProThr-339 347-ThrGlyTyrLysLysProAlaAlaArg-355 360-LeuAspGlyGluMetAlaGlyGlyAsnLysProIleLys-372 377-SerAlaAlaGluLysArgLysGlnAsnPheGluLysPheAsn-390 414-SerProAspLysValLysThrArgTyrThrSerLeuAspGlyLysIleThrIleIleLysAspAsnGluAsn Asn-438 443-HisAspAsnSerArgLysGlnTyrLeu-451 454-AsnGlyAsnAlaValLys-459 462-AsnLeuGlnGlyLysGlnAlaLysAspTyrLeu-472 479-ArgAsnLeuAspLys-483 239-2 AMPHI Regions - AMPHI 49-PheArgLeuIleGlnSerCys-55 72-AsnAlaHisArgLysGln-77 123-ProGlyPheAsnAlaLeuProThrIlePhe-132 165-SerSerAsnGluTrp-169 221-PheCysAlaThrIleCysAlaSerLeuArg-230 Antigenic Index - Jameson-Wolf 6-GlyIleAlaArgAsnArgArgMetGlu-14 19-CysArgArgProAspArgPheValValArgGlnThrArgLeuLeu-33 53-GlnSerCysGluIleGluPro-59 66-HisAsnGlyLysSerGlyAsnAlaHisArgLysGlnGlnLysGluIle-81 100-ProAlaValArgSerAlaThrArgLysThrAla-110 132-PheArgGlySerSerGlyLysSerAlaSer-141 144-AlaAlaGlnArgGlyArgGlyAlaCys-152 164-ArgSerSerAsnGluTrpLys-170 173-ThrAlaLysArgProProSerPheArgArgHisMetThrCysGlyAsnThrAlaProThrSerSerSerSer ArgLeuIleLysMet-201 209-ValAlaGlySerCysProArgSerArgValArgThr-220 245-ArgAlaIleArgArgLeuAsnArgSerSerPro-255 Hydrophilic Regions - Hopp-Woods 6-GlyIleAlaArgAsnArgArgMetGlu-14 20-ArgArgProAspArgPheValValArgGlnThrArg-31 67-AsnGlyLysSerGlyAsnAlaHisArgLysGlnGlnLysGluIle-81 102-ValArgSerAlaThrArgLysThrAla-110 135-SerSerGlyLysSerAlaSer-141 146-GlnArgGlyArgGlyAlaCys-152 165-SerSerAsnGluTrpLys-170 173-ThrAlaLysArgProProSerPheArgArgHisMet-184 193-SerSerSerSerArgLeuIleLysMet-201 211-GlySerCysProArgSerArgValArgThr-220 245-ArgAlaIleArgArgLeuAsnArgSerSerPro-255 240-2 AMPHI Regions - AMPHI 19-AlaAspValGlyArgPheLeuHis-26 63-IleGlnCysLeuArgAsnHis-69 87-AlaProLeuPheAlaValCysPro-94 107-GlnGlyGluAspPheProArgAlaGlyIleGlnAsnHis-119 154-ValPheArgGlyPheIleAlaArgGlyValGlnAlaValHisAsn-168 188-PheLysArgLysPheGln-193 Antigenic Index - Jameson-Wolf 9-GlyThrGluThrArgArgGlnPheAla-17 39-IleAlaHisGlyArgArgSerAspPheIleArg-49 67-ArgAsnHisLysArgPheAspCysArgThrGlyPheAsp-79 lOl-ValGlyGlyArgIleGlyGlnGlyGluAspPheProArgAlaGlyIleGlnAsnHisHisArgSerGly-12 3 139-GlnGlyLeuAsnProLeuIleGluGlyLysAspAspVal-151 173-ValProGlnAsnAspPheArg-179 187-ValPheLysArgLysPhe-192 201-AsnIleGlyLysSerAspAspValCysLys-210 Hydrophilic Regions - Hopp-Woods 10-ThrGluThrArgArgGlnPheAla-17 41-HisGlyArgArgSerAspPheIleArg-49 67-ArgAsnHisLysArgPheAspCys-74 105-IleGlyGlnGlyGluAspPheProArg-113 145-11eGluGlyLysAspAspVal-151 187-ValPheLysArgLysPhe-192 203-GlyLysSerAspAspValCysLys-210 241-1 AMPHI Regions - AMPHI 6-ThrArgAlaAlaAsnProPro-12 35-ThrArgThrProArgGluProAlaSer-43 109-PheLeuIleGlyCysIleAla-115 126-PheHisAlaCysGlnArgMetValAlaVal-135 194-ArgHisIleAspArgIleAlaGlyIleLeuThrValGln-206 229-PheValGlnLysLeuIleValGlyIleIleHis-239 Antigenic Index - Jameson-Wolf 1-MetProThrArgProThrArgAlaAlaAsnProProThrProProThr-lδ 23-CysProArgProProTyrArgProProSerValGlnThrArgThrProArgGluProAlaSerSerThrCysA laAlaLysSerAlaAsnArgArgGluAsnSerHisAsnAlaGlnPro-62 68-ProSerAsnLysMetProSerGluThrGluGlnThrLeuPheArgArgHisGlnIleProProSerCysArgG lnSer-93 122-LeuLysAlaAspPhe-126 147-ThrIleAspAspAsnIleAla-153 166-PheAspPheAsnArgGluHisAlaArgllePheAspThrAspGlnLeu-181 188-ArgIleValGlyArgGlnArgHisIleAspArgIleAla-200 209-PheHisGlnArgGluAsnAla-215 244-ArgAsnHisGlyIle-248 250-HisAspSerHisIleCysProPheArgAsnSerArgLeuIle-263 Hydrophilic Regions - Hopp-Woods 1-MetProThrArgProThrArgAlaAlaAsn-lO 32-SerValGlnThrArgThrProArgGluProAlaSer-43 46-CysAlaAlaLysSerAlaAsnArgArgGluAsnSerHis-58 70-AsnLysMetProSerGluThrGluGlnThrLeuPheArg-82 122-LeuLysAlaAspPhe-126 166-PheAspPheAsnArgGluHisAlaArgIlePheAsp-177 188-ArgIleValGlyArgGlnArgHisIleAspArgIleAla-200 209-PheHisGlnArgGluAsnAla-215 242 AMPHI Regions - AMPHI 23-SerGluValValThrGlnPheValAspPheValGlu-34 42-AlaGlyPheCysHisIleLeuGlnAsn-50 lOO-AlaAspGlnAlaGln-104 122-AsnProPhePheAspPhePheGlnAlaValVal-132 137-HisGlnSerGlyPheGlyAspValPhe-145 156-LeuGluGlnSerVal-160 177-PheGluLeuPheGln-181 191-PheGlyHisThrArgLeuPheAspIleCys-200 262-HisProPheAlaAspPheGlyAsnPheGlnAsnLeuLeuAlaLeu-276 Antigenic Index - Jameson-Wolf 13-HisPheGluGlnArgAlaGlyGlyIleAla-22 33-ValGluGlnGluGln-37 52-ThrGlyHisArgAlaAspIle-58 75-SerHisAlaAspIlePheProProArgCysPheGlyAspGlyPheAlaGlnArgGlyPheAlaHisAlaArgA rgAlaAspGlnAlaGlnAsnArgAla-107 137-HisGlnSerGlyPhe-141 154-ArgGlnLeuGluGlnSerVal-160 164-AlaTyrAspGlyGlyPheArgArgHisArgTrpHis-175 283-MetArgCysAspArgIleGly-289 Hydrophilic Regions - Hopp-Woods 13-HisPheGluGlnArgAlaGlyGlyIle-21 33-ValGluGlnGluGln-37 52-ThrGlyHisArgAlaAspIle-58 95-AlaHisAlaArgArgAlaAspGlnAlaGlnAsnArgAla-107 154-ArgGlnLeuGluGlnSerVal-160 167-GlyGlyPheArgArgHisArg-173 283-MetArgCysAspArgIleGly-289 243 AMPHI Regions - AMPHI 35-IleThrArgLeuAlaArgLysAlaValGlnArgLeuThr-47 50-HisIleGlnXxxPhePheThrGlu-57 80-AspSerSerArgIleThrSerThrIle-88 Antigenic Index - Jameson-Wolf 29-LeuProSerAsnAlaPro-34 37-ArgLeuAlaArgLysAlaValGln-44 58-SerHisThrGlyAlaAsnArgSerSerSerSerCysLysPro-71 77-SerAlaSerAspSerSerArgIle-84 102-ΞerThrThrGlyAlaValThrLysSer-llO Hydrophilic Regions - Hopp-Woods 37-ArgLeuAlaArgLysAlaValGln-44 59-HisThrGlyAlaAsnArgSerSerSerSerCysLys-70 78-AlaSerAspSerSerArgIle-84 244-2 AMPHI Regions - AMPHI 22-LysCysPheLeuGlnLeuValGln-29 31-HisLeuHisAlaHis-35 109-IleSerArgLeuCysGlySerLeuPhe-117 126-CysLeuAspGlyPheHisArgLeuHis-134 137-AsnArgPhePheThr-141 165-TyrProArgLys11eArgThrPheSerArgAsnPheLysGlnLys-179 Antigenic Index - Jameson-Wolf l-MetAspIleArgIle-5 H-PheArgValAspPheLeuAsp-17 45-IleGlnLysArgHis-49 54-LeuAspArgGlnHisPheHisGlyLysLeuLeuSerGlyGluLeuValArg-70 99-GlnLeuGlyAsnProArgLeu-105 154-LeuLysThrAsnTrpLysSerLysSerSerTyrTyrProArgLysIleArgThrPheSerArgAsnPheLys GlnLysGlnArgIleSerAsnSerPheSerAsnProLeuProLysLys-193 Hydrophilic Regions - Hopp-Woods l-MetAspIleArgIle-5 11-PheArgValAspPheLeuAsp-17 156-ThrAsnTrpLysSerLysSer-162 167-ArgLysIleArgThrPheSerArgAsnPheLysGlnLysGlnArgIle-182 246-2 AMPHI Regions - AMPHI 39-AlaValAsnIleAlaGlnCysPheThr-47 67-GluGlnPheAlaAsnLeuPhePhe-74 83-AspMetGlyArgPhe-87 132-PheGlyCysAspAspValValAspAsnLeuAlaGlyPheGlyArg-146 156-GlnLeuSerGlnValPhePheGlnLeuLeuGln-166 Antigenic Index - Jameson-Wolf 1-MetHisGlyArgTyrGlyGlyThrGln-9 18-GlnThrGlnArgThrCysPheSerAsnGlyLysValTyr-30 34-ThrAspIleGlySer-38 59-GlnArgArgThrGluValLeu-65 78-AspSerArgHisHisAspMetGlyArg-86 92-LeuAspAspGluLeuAla-97 133-GlyCysAspAspValValAspAsn-140 143-GlyPheGlyArgGlyPhe-148 Hydrophilic Regions - Hopp-Woods 59-GlnArgArgThrGluValLeu-65 78-AspSerArgHisHisAspMet-84 92-LeuAspAspGluLeuAla-97 247-1 AMPHI Regions - AMPHI 12-SerTyrAspGlyMetLysGlyPheThrIleIle-22 25-LeuValAlaGlyLeuLeuSerMetIleValLeu-35 48-LeuAsnAspAlaAlaAsn-53 81-CysPheAsnMetSerGlu-86 123-AsnTyrGlnAsnPhePheGln-129 150-ThrValValSerSerCysAlaAlaIleSerLysProGlyLysGlnIleProThrLeu-168 256-LysTyrThrAspLysPheAspSerAla-264 Antigenic Index - Jameson-Wolf l-MetArgArgLysMetLeuAsnValProLysGlySerTyrAspGlyMetLys-17 42-TyrPheThrSerArgLysLeuAsnAspAlaAlaAsnGluArgLeuAlaAla-58 60-GlnAspLeuArgAsn-64 71-ArgAspAlaArgMetAlaGlyGlyPhe-79 83-AsnMetSerGluHisProAlaThrAspValIleProAspThrThrGlnGlnAsnSerProPheSerLeuLysA rgAsnGlyIleAspLys-112 117-AlaGluSerSerAsnIleAsnTyrGln-125 140-IleAspAspValAsnAlaSerThr-147 157-AlaIleSerLysProGlyLysGlnIleProThrLeuGluAspAlaLysLysGluLeuLysIleProAspGln AspLysGluGlnAsnGlyAsnIleAlaArgGlnArgHis-193 202-ArgIleAlaAspGluGluGlyLeu-209 212-PheGlnLeuAspAspLysGlyLysTrpGlyAsn-222 228-LysLysValArgHisMetLys-234 242-GlyCysProGluAspAspAspAlaGlyLysGluGluThrPheLysTyrThrAspLysPheAspSerAlaGln -265 279-SerGlyThrAspThrLysIleAlaAlaSerSerAspAsnHis-292 300-AlaThrIleArgGlyGlyAsnValCysAlaAsnArgThrLeu-313 Hydrophilic Regions - Hopp-Woods l-MetArgArgLysMetLeuAsn-7 H-GlySerTyrAspGly-15 46-ArgLysLeuAsnAspAlaAlaAsnGluArgLeuAlaAla-58 60-GlnAspLeuArgAsn-64 71-ArgAspAlaArgMet-75 104-SerLeuLysArgAsnGly11eAspLys-112 140-IleAspAspValAsnAla-145 159-SerLysProGlyLysGln-164 166-ProThrLeuGluAspAlaLysLysGluLeuLysIleProAspGlnAspLysGluGlnAsnGlyAsnIleAla ArgGlnArgHis-193 202-ArgIleAlaAspGluGluGlyLeu-209 213-GlnLeuAspAspLysGlyLysTrpGly-221 228-LysLysValArgHisMetLys-234 243-CysProGluAspAspAspAlaGlyLysGluGluThrPheLysTyrThrAspLysPheAspSerAlaGln-26 5 280-GlyThrAspThrLysIleAlaAlaSerSerAsp-290 248-2 Hydrophilic Regions - Hopp-Woods l-MetArgArgLysMetLeuAsn-7 H-GlySerTyrAspGly-15 46-ArgLysLeuAsnAspAlaAlaAsnGluArgLeuAlaAla-58 60-GlnAspLeuArgAsn-64 71-ArgAspAlaArgMet-75 104-SerLeuLysArgAsnGlyIleAspLys-112 140-IleAspAspValAsnAla-145 159-SerLysProGlyLysGln-164 166-ProThrLeuGluAspAlaLysLysGluLeuLysIleProAspGlnAspLysGluGlnAsnGlyAsnIleAla ArgGlnArgHis-193 202-ArgIleAlaAspGluGluGlyLeu-209 213-GlnLeuAspAspLysGlyLysTrpGly-221 228-LysLysValArgHisMetLys-234 243-CysProGluAspAspAspAlaGlyLysGluGluThrPheLysTyrThrAspLysPheAspSerAlaGln-26 5 280-GlyThrAspThrLysIleAlaAlaSerSerAsp-290 Antigenic Index - Jameson-Wolf l-MetArgLysGlnAsnThrLeuThr-8 ll-ProThrSerAspGlyGlnArgGly-18 40-GlnSerTyrAsnThrGluGlnArgIleSerAlaAsnGluSerAspArgLysLeuAla-58 64-AlaAlaLeuArgGluGlyGluLeuGln-72 76-LeuGluTyrAspThrAspSerLysValThrPheSerGluAsnCysGlyLysGlyLeu-94 99-AsnValArgThrAsnAsnAspAsnGluGluAlaPhe-110 116-GlnGlyLysProThrValGluAlaValLysArgSerCysProAlaAsnSerThrAspLeuCysIleAspLys LysGlyMetGluTyrLysLysGlyThrArgSerValSerLysMetProArgTyr-157 162-LeuGlyValLysAsnGlyGluAsnValTyr-171 177-AlaTrpGlyLysAsnAlaAsnThr-184 192-ValSerAsnAsnAspGlu-197 Hydrophilic Regions - Hopp-Woods l-Me ArgLysGlnAsnThr-6 11-ProThrSerAspGlyGlnArg-17 42-TyrAsnThrGluGlnArgIleSerAlaAsnGluSerAspArgLysLeuAla-58 64-AlaAlaLeuArgGluGlyGluLeuGln-72 76-LeuGluTyrAspThrAspSerLysValThrPhe-86 101-ArgThrAsnAsnAspAsnGluGluAlaPhe-110 119-ProThrValGluAlaValLysArgSerCysPro-129 135-LeuCysIleAspLysLysGlyMetGluTyrLysLysGlyThrArgSerValSerLysMetPro-155 165-LysAsnGlyGluAsnValTyr-171 193-SerAsnAsnAspGlu-197 249-1 AMPHI Regions - AMPHI 6-CysPheArgLeuLys-10 17-AlaLeuIleGluValLeuVal-23 42-ThrValAlaSerValArgGluAla-49 53-ThrIleValSerGlnIleThrGlnAsnLeuMetGluGlyMet-66 Antigenic Index - Jameson-Wolf l-MetLysAsnAsnAspCysPheArgLeuLysAspSerGlnSerGlyMetAla-17 44-AlaSerValArgGluAlaGluThr-51 70-ProThrIleAspSerAspSerAsnLysLysAsnTyr-81 93-ValAspGlyAspPheAla-98 101-AlaMetLysThrLysGlyGlnLeuAla-109 134-ValCysLysAspSerSerGlyAsnAlaProThrLeuSer-146 148-AsnAlaPheSerSerAsnCysAspAsnLysAlaAsnGlyAspThrLeu-163 171-AspSerAlaGlyAspSerAspIleSerArgThrAsnLeuGluValSerGlyAspAsn-189 196-AlaArgValGlyGlyArgGlu-202 Hydrophilic Regions - Hopp-Woods 1-MetLysAsnAsnAspCysPheArgLeuLysAspSerGlnSer-14 44-AlaSerValArgGluAlaGluThr-51 72-1leAspSerAspSerAsnLysLysAsn-80 101-AlaMetLysThrLysGlyGlnLeuAla-109 134-ValCysLysAspSerSerGly-140 153-AsnCysAspAsnLysAlaAsnGly-160 172-SerAlaGlyAspSerAspIleSerArgThrAsnLeu-183 198-ValGlyGlyArgGlu-202 250-2 AMPHI Regions - AMPHI 34-PheAlaGlyGlySerGlu-39 41-AlaThrValAsnLeuTrpAlaGluPro-49 123-LeuThrLysThrSerThrAlaLeuPro-131 Antigenic Index - Jameson-Wolf 14-MetGlnGlyGlyGlnLysGlyMetSer-22 35-AlaGlyGlySerGlu-39 80-IleProLeuLysLysAlaVal-86 103-GluIleGlnLysArgLysAlaAla-110 119-PheTyrSerGlyLeuThrLysThrSerThrAlaLeuProArgLeuSerSerLysLysThrIle-139 Hydrophilic Regions - Hopp-Woods 80-IleProLeuLysLysAlaVal-86 103-GluIleGlnLysArgLysAlaAla-llO 133-LeuSerSerLysLysThrIle-139 251 AMPHI Regions - AMPHI 59-AlaTyrGlyAspProIleGlyAlaGlyPhe-68 114-GlnValValAlaAspPheGlyGlyIleGluGlyPhe-125 160-ArgThrValGlyArgThrValArgLeuLeuLysMetIle-172 215-AlaArgThrValPheArgAlaHis-222 260-LeuGlyGlnGluCysArg-265 267-ArgHisIleAlaArgValGluSerLeuLeuArgValPheGluTyrAlaAlaAsp-284 Antigenic Index - Jameson-Wolf 10-AlaArgAlaAspIleArgProProAlaGlnThrAspIleValProAsnCys-26 34-AspAlaAlaArgArgAlaValArg-41 49-AlaAspLeuProArgAsnAspIleSerProAlaTyrGlyAspProIleGlyAlaGly-67 80-LeuArgGlyArgValArgArgIleGly-88 101-GluIleArgAlaLysAlaValLysProGluIle-lll 149-ArgLeuValGlyThr-153 161-ThrValGlyArgThrValArg-167 179-ProValValArgGluAlaGlyIle-186 212-ValLysHisAlaArgThrValPhe-219 244-ValThrGlyGlnArgThrArg-250 256-IleLysAsnArgLeuGlyGlnGluCysArgAsnArgHisIleAlaArgValGluSer-274 290-LeuLysThrLysThrArgAlaGluGlnProArgProAlaPhe-303 Hydrophilic Regions - Hopp-Woods 10-AlaArgAlaAspIleArgProProAlaGln-19 34-AspAlaAlaArgArgAlaValArg-41 50-AspLeuProArgAsnAspI1e-56 82-GlyArgValArgArgIleGly-88 101-GluIleArgAlaLysAlaValLysProGluIle-lll 161-ThrValGlyArgThrValArg-167 179-ProValValArgGluAlaGlyIle-186 212-ValLysHisAlaArgThrValPhe-219 258-AsnArgLeuGlyGlnGluCysArgAsnArgHisIleAlaArgValGluSer-274 292-ThrLysThrArgAlaGluGlnProArg-300 254-2 AMPHI Regions - AMPHI 6-ArgPheAsnThrTyrSerHis-12 32-GlyHisGlyAspGlyTyrArg-38 66-LysLeuLysSerIleLeuLys-72 142-ValLeuAlaValMetLysSerLeuThrAlaSerLeuPro-154 Antigenic Index - Jameson-Wolf 2-TyrThrGlyGluArgPheAsnThrTyrSer-ll 32-GlyHisGlyAspGlyTyrArg-38 65-GlyLysLeuLysSerIleLeuLysLysThrAspHis-76 94-SerLeuArgAsnGlyProGly-100 120-ThrIleGlyArgLysSerGluLysArgLeu-129 177-AsnAspGluLysIleArgHisGlyHisGly-186 Hydrophilic Regions - Hopp-Woods 65-GlyLysLeuLysSerIleLeuLysLysThrAspHis-76 120-ThrIleGlyArgLysSerGluLysArgLeu-129 177-AsnAspGluLysIleArgHis-183 255 AMPHI Regions - AMPHI 23-ValLysThrCysAlaAspPheHisAlaPheAspGlyValAspAlaHisHisArg-40 71-GlyIleGlnGlyPheAlaHis-77 139-AlaGlyGlyGlyPhe-143 Antigenic Index - Jameson-Wolf 33-AspGlyValAspAlaHisHisArgValGlyAspPheGly-45 48-AlaValLysAsnArgPheAlaGlnAlaAspArgAspIleGlyCys-62 66-GlnLeuArgAlaAspGlyIleGln-73 91-ValGlyGlyLysLysArgIleLeu-98 115-GlyAsnValGlyGlyAspPheArgAla-123 130-PhePheGlyAsnGlySerGlySerAsnAlaGlyGly-141 143-PheThrGlyGlyAla-147 169-GlyAlaGluAlaGlyGly-174 Hydrophilic Regions - Hopp-Woods 33-AspGlyValAspAlaHisHisArgValGlyAspPheGly-45 48-AlaValLysAsnArgPheAlaGlnAlaAspArgAspIleGly-61 66-GlnLeuArgAlaAspGly-71 92-GlyGlyLysLysArgIleLeu-98 119-GlyAspPheArgAla-123 135-SerGlySerAsnAla-139 169-GlyAlaGluAlaGlyGly-174 256-1 AMPHI Regions - AMPHI 90-GlyValValValHisPheArgSerCysGlyGlyIleAlaAsn-103 127-ArgTyrArgGluIleTyrAlaVal-134 141-AsnAlaLeuAlaLysTyrLeuGlyGluGln-150 173-ArgArgPheAspSerGly11eThrArgLeuLeu-183 197-LysSerLeuGlnGlyPheGlnThrAla-205 207-AlaAlaGlyCysLysThrLeuGlyGluPheAspAspArgPheThrAlaProLeuHisGly-226 233-TyrTyrArgGlnThrSerCysLysProLeuLeuLysHisValAla-247 267-ProArgAlaAspGluValSer-273 Antigenic Index - Jameson-Wolf 4-ThrProProAspThrProPhe-10 12-LeuArgAsnGlyAsnAlaAspThrIleAla-21 24-PheLeuGlnArgProAlaProAlaTyrArgArgGluLeuLeuProAspSerThrGlyLysThrLysVal-46 49-AspPheSerAspGlyIleSerProAspAla-58 67-LeuGluGlySerSerArgSerHisTyr-75 82-AlaValArgAspArgGlyTrpHis-89 112-GlyAspThrAlaGlu-116 147-LeuGlyGluGlnGlyLysLysAlaLeu-155 166-ValAspAlaGluAlaAlaGlyArgArgPheAspSerGlyIleThr-180 192-LeuIleProLysAlaLysSerLeuGln-200 212-ThrLeuGlyGluPheAspAspArgPheThr-221 227-PheAlaAspArgHisAspTyrTyrArgGlnThrSerCysLysProLeuLeu-243 259-ProPheLeuProProGluAlaLeuProArgAlaAspGluValSerGlu-274 291-SerSerThrGlyGlyArgLeu-297 311-AspSerPheArgThrAsnArgArg-318 Hydrophilic Regions - Hopp-Woods 30-ProAlaTyrArgArgGluLeuLeuPro-38 40-SerThrGlyLysThrLysVal-46 68-GluGlySerSerArgSer-73 83-ValArgAspArgGlyTrp-88 147-LeuGlyGluGlnGlyLysLysAlaLeu-155 166-ValAspAlaGluAlaAlaGlyArgArgPheAspSerGlyIle-179 192-LeuIleProLysAlaLysSer-198 212-ThrLeuGlyGluPheAspAspArgPheThr-221 227-PheAlaAspArgHisAspTyrTyrArg-235 265-AlaLeuProArgAlaAspGluValSerGlu-274 313-PheArgThrAsnArgArg-318 257-2 AMPHI Regions - AMPHI 24-SerPheLeuProAsn-28 73-AspLeuValAsnLysValLeuAlaGluValAlaArgLeuGluLysIleValGlnProLeu-92 Antigenic Index - Jameson-Wolf 1-MetGlyArgHisPheGlyArgArgArgPhe-lO 31-AlaAlaAspAspGluLysArgAsnGlyAspGluLysArgAsnGluAsn-46 56-GlySerGlyAlaGlu-60 65-GlyValAspAspArgArgAlaAlaAspLeuVal-75 83-AlaArgLeuGluLysIleVal-89 Hydrophilic Regions - Hopp-Woods 4-HisPheGlyArgArgArgPhe-10 31-AlaAlaAspAspGluLysArgAsnGlyAspGluLysArgAsnGlu-45 65-GlyValAspAspArgArgAlaAlaAspLeuVal-75 83-AlaArgLeuGluLysIleVal-89 259-1 AMPHI Regions - AMPHI 154-TyrGlyArgValPheAlaAspIlePheGluLeuSer-165 172-AlaPheLysGlyMetLeuLysLeuThrAlaGluTyrLysAsnIlePheGlyAspAlaCysArg-192 203-AsnGlnAlaLeuGlnGluIleSerLysThrSerGlu-214 Antigenic Index - Jameson-Wolf 34-LysAlaTyrThrGluGluLeuProPro-42 61-SerAlaArgSerLysAlaLysAlaGluLysPheTyrArgGluLysMetIleGln-78 93-LeuGluHisLysPro-97 105-LysAsnHisGlyLysGlyMetAlaGluGlnValArgPheLysAla-119 121-ValLeuProAspAspGluAspAlaArgThrIleAla-132 144-GlyThrAspAlaValAlaSerGlyGluThrTyrGlyArgVal-157 168-LeuGluGlyArgAlaPhe-173 189-AspAlaCysArgSerGluThrAlaLeu-197 208-GluIleSerLysThrSerGluLysSerLysArg-218 Hydrophilic Regions - Hopp-Woods 35-AlaTyrThrGluGluLeuPro-41 62-AlaArgSerLysAlaLysAlaGluLysPheTyrArgGluLysMetIleGln-78 93-LeuGluHisLysPro-97 106-AsnHisGlyLysGlyMetAlaGluGlnValArgPheLysAla-119 121-ValLeuProAspAspGluAspAlaArgThrIleAla-132 168-LeuGluGlyArgAlaPhe-173 189-AspAlaCysArgSerGluThrAlaLeu-197 208-GluIleSerLysThrSerGluLysSerLysArg-218 260-2 AMPHI Regions - AMPHI 12-ProPheSerSerLeuPheArgAlaLeuPhe-21 53-PheIleAspSerValGlyGlnValAlaAlaArgLeuPheGlnAlaPhe-68 158-GlnValGlyIleValAspLeuIlePro-166 175-LeuProArgAlaValGln-180 Antigenic Index - Jameson-Wolf 20-LeuPheGluAspArgValGlyIle-27 30-GlyAlaHisAspAlaAlaGlu-36 38-AspPheLeuProGluGluPheThrArg-46 80-ProAlaPheArgAlaArgGluGlnAlaArgArgGlySerGly-93 97-GlyAsnAspLeuArgMetProHisLysAspAlaValGluValAspIleAspGlyGlyAsnThrVal-ll{ 126-ThrHisPheAspAspGlyAspAla-133 139-AlaGluAlaArgPhe-143 184-ArgAsnAlaProGlnGly-189 196-ValAlaPheArgArgValArgAla-203 Hydrophilic Regions - Hopp-Woods 20-LeuPheGluAspArgValGlyIle-27 30-GlyAlaHisAspAlaAlaGlu-36 82-PheArgAlaArgGluGlnAlaArgArgGlySer-92 98-AsnAspLeuArgMetProHisLysAspAlaValGluValAspIleAspGly-114 127-HisPheAspAspGlyAspAla-133 139-AlaGluAlaArgPhe-143 196-ValAlaPheArgArgValArgAla-203 261 AMPHI Regions - AMPHI 22-GlnllePheArgGln-26 32-AspThrAlaArgAlaPheAlaAlaAla-40 50-GlyLeuLeuAlaAspIle-55 94-ArgPheAspLysHis-98 137-AlaValTyrLysGlyIleArgAsnAlaValPhe-147 158-GlnGlyIleValArgAsnLeu-164 203-AspValPheAlaProVal-208 212-CysLeuAsnGlnAlaGlyGly-218 Antigenic Index - Jameson-Wolf 40-AlaAlaAspAspAlaVal-45 62-ValArgGlnArgProArgLeuArgLeu-70 74-HisGlnArgArgValAspLeu-80 86-ArgGlnIleLysGlyAsnValHisArgPheAspLysHisVal-99 lll-AlaHisAlaArgAspAspValProTyr-119 126-AsnArgGlyIleGluGlnGluLysArgVal-135 149-SerPheAspGlyGlyGly-154 181-ArgAsnProAlaGly-185 197-LeuGluSerAsnGlyLeuAsp-203 214-AsnGlnAlaGlyGlyArgIleLeuThrAlaArgLysAspAspGlnGlyLeu-230 Hydrophilic Regions - Hopp-Woods 40-AlaAlaAspAspAlaVal-45 62-ValArgGlnArgProArgLeuArgLeu-70 74-HisGlnArgArgValAspLeu-80 91-AsnValHisArgPheAspLysHisVal-99 112-HisAlaArgAspAspValPro-118 127-ArgGlyIleGluGlnGluLysArgVal-135 221-LeuThrAlaArgLysAspAspGlnGly-229 263-2 AMPHI Regions - AMPHI 32-AsnLeuIleGlyValLeuSerAsnAla-40 42-GluAlaLeuAlaPheTyrGlnGluValGlyLysLeuAsnAlaAlaAsnSerLeuThr-60 86-LysLeuAlaThrLeuLysLys-92 100-LysAlaAlaArgAlaLeuAlaAlaGlyGlu-109 115-LeuGlyAlaLeuAlaAlaPheThrGln-123 135-GluGluLeuLysAlaPhePheAspAla-143 157-ValAlaLeuAlaThrLeuCysAsnTyrValAsnAsnLeuGly-170 Antigenic Index - Jameson-Wolf 10-GluThrAlaProGluAlaAlaLysAlaArgValGluAla-22 37-LeuSerAsnAlaPro-41 72-AlaArgThrAsnGlnCysGly-78 97-GlnSerValLysAlaAlaArg-103 108-GlyGluPheAspAspAlaLysLeu-115 126-MetAlaLysLysGlyAlaValSerAspGluGluLeuLysAla-139 170-GlyGlnThrGluIleAsnProGluLeu-178 Hydrophilic Regions - Hopp-Woods ll-ThrAlaProGluAlaAlaLysAlaArgValGluAla-22 97-GlnSerValLysAlaAlaArg-103 108-GlyGluPheAspAspAlaLysLeu-115 126-MetAlaLysLysGlyAlaValSerAspGluGluLeuLysAla-139 264 AMPHI Regions - AMPHI 55-ValAlaGluPheThrGlnThrGly-62 96-IleProSerTyrValArgValThrAsnThrLys-106 124-AsnArgIleIleAspValSer-130 183-LeuAsnGlnAlaAla-187 Antigenic Index - Jameson-Wolf 27-AlaValValLysAlaGluLysLeuHisAlaSerAlaAsnArgSerTyrLysValAlaGlyLysArgTyrThrP roLysAsnGlnVal-55 57-GluPheThrGlnThrGlyAsnAlaSerTrp-66 68-GlyGlyArgPheHisGlyArgLysThrSerGlyGlyGluArgTyrAsp-83 103-ThrAsnThrLysAsnGlyLysSerVal-lll 114-ArgValAsnAspArgGlyProPheHisGlyAsnArgIleIleAspValSerLysAlaAlaAla-134 153-ValProGlyGlnSerAlaProValAlaGluAsnLysAspIlePheIle-168 170-LeuLysΞerPheGlyThrGluHisGluAla-179 200-SerValGluLysArgArgTyrGluTyr-208 213-GlyProPheThrSerGlnGluArgAlaAlaGluAlaGluAlaGlnAla-228 Hydrophilic Regions - Hopp-Woods 27-AlaValValLysAlaGluLysLeuHisAlaSerAlaAsnArgSerTyrLysValAlaGlyLysArgTyrThrP ro-51 71-PheHisGlyArgLysThrSerGlyGlyGluArgTyrAsp-83 103-ThrAsnThrLysAsnGlyLys-109 115-ValAsnAspArgGlyProPheHis-122 125-ArgIleIleAspValSerLysAlaAlaAla-134 159-ProValAlaGluAsnLysAspIlePheIle-168 171-LysSerPheGlyThrGluHisGluAla-179 200-SerValGluLysArgArgTyrGluTyr-208 216-ThrSerGlnGluArgAlaAlaGluAlaGluAlaGlnAla-228 266-2 Antigenic Index - Jameson-Wolf 3 O-AlaLeuLysArgLysHisPhe-36 57-LeuGluSerArgAlaGlySerValHisAspGlnGlyTrpGlu-70 93-TrpHisThrArgAsnArgGlu-99 Hydrophilic Regions - Hopp-Woods 30-AlaLeuLysArgLysHisPhe-36 59-SerArgAlaGlySerValHis-65 268-1 AMPHI Regions - AMPHI 6-AspGlyLeuHisLysPheLysHisIleCysSerAlaAla-18 22-IleLysGluProLeuAspLysVal-29 52-GlnGluAlaAlaArgValSerGluTrp-60 70-GluPheGluGlnPheTrpLysGlyLeuProGlnThrValGlnAsn-84 89-SerGlnLysThrTrpLysSerGlyMetAspLys-99 110-LysThrProAsnGlyIleLys-116 Antigenic Index - Jameson-WoIf l-ValGlnSerArgTyrAspGly-7 21-LeuIleLysGluProLeuAspLysValLysGlnArgAsnGluGluLeuGluAlaAlaGluGluAlaAlaAla- 44 47-AlaLeuGlyArgGluGlnGluAlaAlaArgValSerGluTrpGluGluArgTyrLysLeuSerArgSerGluP he-71 82-ValGlnAsnLysLeuGlnAlaSerGlnLysThrTrpLysSerGlyMetAspLysIleCysAlaAsnAsnAlaL ysAlaGluGlyLysThrProAsnGlyIleLysPhe-117 119-GluLeuAlaCysLysThrAlaLysThrGluAlaArgLeuGluGluLeuHisAsnArgLysLysAlaLeuIle AspGluMetAlaArgGluAlaAspLysLysGluLeuSerLysArgLeu-158 Hydrophilic Regions - Hopp-Woods 3-SerArgTyrAspGly-7 21-LeuIleLysGluProLeuAspLysValLysGlnArgAsnGluGluLeuGluAlaAlaGluGluAlaAlaAla- 44 47-AlaLeuGlyArgGluGlnGluAlaAlaArgValSerGluTrpGluGluArgTyrLysLeuSerArgSerGluP he-71 91-LysThrTrpLysSerGlyMetAspLysIleCys-101 104-AsnAlaLysAlaGluGlyLysThrProAsn-113 119-GluLeuAlaCysLysThrAlaLysThrGluAlaArgLeuGluGluLeuHisAsnArgLysLysAlaLeuIle AspGluMetAlaArgGluAlaAspLysLysGluLeuSerLysArgLeu-158 269-2 AMPHI Regions - AMPHI 39-AlaSerValProAla-43 54-TrpAspPheIleGlnAsnThr-60 73-PheLysThrArgAlaLeuGlyArgPheSerSerPro-84 Antigenic Index - Jameson-Wolf 30-ArgSerAlaLeuSerCysLysProCysAlaSerValProAlaSerSer-45 60-ThrAlaSerProLysValSer-66 73-PheLysThrArgAlaLeuGlyArgPheSerSer-83 90-LeuSerGluArgGlyValLysLysProLeu-99 107-GlnValAspThrSerAla-112 117-SerLeuArgSerSer-121 Hydrophilic Regions - Hopp-Woods 61-AlaSerProLysVal-65 73-PheLysThrArgAlaLeuGly-79 90-LeuSerGluArgGlyValLysLysProLeu-99 270-2 AMPHI Regions - AMPHI 41-AspLeuThrGluGlyCys-46 49-ProAspGlySerArg-53 100-GlnProSerGlyThrTrp-105 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnArgLysLeu-7 41-AspLeuThrGluGlyCysThrLeuProAspGlySerArgValArgAlaAlaAlaValSerThrLysLysProP he-65 71-HisAlaProAlaGlyThrGlu-77 86-LysAsnMetAspMetGlyPhe-92 95-TyrMetPheGluArgGlnProSerGlyThr-104 116-ValGluGlyArgArgAspPheThrAla-124 128-IleGlySerArgThrPhe-133 Hydrophilic Regions - Hopp-Woods l-MetAsnLysAsnArgLysLeu-7 49-ProAspGlySerArgValArgAla-56 60-SerThrLysLysProPhe-65 73-ProAlaGlyThrGlu-77 96-MetPheGluArgGlnPro-101 116-ValGluGlyArgArgAspPheThrAla-124 271-2 AMPHI Regions - AMPHI 6-MetAlaArglleTrp-10 20-SerProCysProAla-24 29-ProLysSerProAla-33 Antigenic Index - Jameson-Wolf 2-PheSerSerArgMetAlaArg-8 25-LeuThrThrLysProLysSerProAlaLys-34 41-ArgSerAsnCysLeu-45 61-SerSerThrThrGlyAlaProThrSerArg-70 78-SerAlaSerIleAsnLysAspThrArgMetProAlaSerVal-91 102-CysCysAlaAsnThrSerLysProProSer-lll Hydrophilic Regions - Hopp-Woods 27-ThrLysProLysSerProAlaLys-34 80-SerIleAsnLysAspThrArgMet-87 105-AsnThrSerLysProPro-llO 272-2 AMPHI Regions - AMPHI 44-IleThrArgIleThrAspGlu-50 70-AlaGluGluPheSerSerThrAsn-77 106-PheArgThrIleThrSer-lll 165-IleIleThrIleGluAspProIleGlu-173 194-AsnTrpMetAlaAlaLeuLysAsnThrLeuArgGlnAla-206 244-AsnGlnAlaLeuAspArgIleIleAsn-252 307-GlyAsnIleHisGluIleLysGluValMetLys-317 328-AspGlnHisLeuTyrGln-333 345-AlaLeuLysAsnAlaAspSer-351 Antigenic Index - Jameson-Wolf 2-PheThrAspGluAsnMetThrAlaLysGluGluLeu-13 20-MetAsnGlnAsnLysGlySerAsp-27 38-MetLysLeuAspGlyLysIleThrArgIleThrAspGluProLeuThrAlaGluLysCysMet-58 68-LysGlnAlaGluGluPheSerSerThrAsnGlu-78 85-LeuProAspThrSerArgPheArgVal-93 109-IleThrSerLysIleProLysPheGluSerLeuAsn-120 128-ValAlaLeuLysLysArgGly-134 142-ThrGlySerGlyLysSerThrSerLeu-150 154-11eAspTyrArgAsnGluAsnSerPheGly-163 168-IleGluAspProIle-172 176-HisGluHisLysAsnCys-181 184-ThrGlnArgGluValGlyValAspThrGluAsn-194 199-LeuLysAsnThrLeuArgGlnAlaProAsp-208 214-GluIleArgAspArgGluThrMet-221 241-AsnSerThrAsnGlnAlaLeuAspArg-249 254-PheProGluGluArgArgGluGlnLeuLeu-263 278-LeuValProArgAspGlyGlyLysGlyArgValAlaAla-290 310-HisGluIleLysGluValMetLysLysSerThr-320 334-LeuTyrGluLysGlyAspIleSerLeu-342 344-GluAlaLeuLysAsnAlaAspSerAlaHisAspLeu-355 361-LeuArgSerArgArgAlaGlnSerSerSerProAspLeuGluLeu-375 Hydrophilic Regions - Hopp-Woods 2-PheThrAspGluAsnMetThrAlaLysGluGluLeu-13 20-MetAsnGlnAsnLysGlySerAsp-27 38-MetLysLeuAspGlyLysIleThrArgIleThrAspGluProLeuThrAlaGluLysCysMet-58 68-LysGlnAlaGluGluPheSerSer-75 87-AspThrSerArgPheArgVal-93 112-LysIleProLysPheGluSer-118 128-ValAlaLeuLysLysArgGly-134 143-GlySerGlyLysSerThrSer-149 155-AspTyrArgAsnGluAsnSer-161 168-IleGluAspProIle-172 176-HisGluHisLysAsn-180 184-ThrGlnArgGluValGlyValAspThr-192 201-AsnThrLeuArgGlnAlaPro-207 214-GluIleArgAspArgGluThrMet-221 245-GlnAlaLeuAspArg-249 255-ProGluGluArgArgGluGlnLeuLeu-263 278-LeuValProArgAspGlyGlyLysGlyArgValAlaAla-290 310-HisGluIleLysGluValMetLysLysSerThr-320 336-GluLysGlyAspIleSerLeu-342 344-GluAlaLeuLysAsnAlaAspSerAlaHisAspLeu-355 361-LeuArgSerArgArgAlaGlnSerSerSerProAspLeuGluLeu 274 AMPHI Regions - AMPHI 31-TyrLysAspGlyLys-35 lll-GluAlaValPheLysThrLeuSerPro-119 Antigenic Index - Jameson-Wolf 25-LeuValThrAspAspTyrTyrLysAspGlyLysHis11eAsp-38 40-GlnLeuHisArgAspGluGluAlaValArgArgHisIle-52 60-ProAspMetAsnAla-64 71-GlyGluPheAspGlyLysGlnPro-78 85-HisProThrArgLysAlaAspAspGlnThrVal-95 99-ProValGlySerAlaGlnAsnGlyArgAlaGluTyr-110 117-LeuSerProThrAsnHis-122 126-ArgValGluAspAlaAlaGly-132 136-ValGluAsnLysTrpIleThrSerGlnGlyAsnAlaValAspLeuThrProMetAspLysLeuPheAsnAsn ThrGluSerLys-163 Hydrophilic Regions - Hopp-Woods 29-AspTyrTyrLysAspGlyLysHisIleAsp-38 40-GlnLeuHisArgAspGluGluAlaValArgArgHisIle-52 72-GluPheAspGlyLysGln-77 86-ProThrArgLysAlaAspAspGlnThrVal-95 104-GlnAsnGlyArgAlaGluTyr-llO 126-ArgValGluAspAlaAlaGly-132 151-ThrProMetAspLysLeuPheAsn-158 276 AMPHI Regions - AMPHI 9-MetMetArgSerAlaProSerMetValValArgArgTrpAlaThrMetMet-25 60-SerPheLysMetAlaArg-65 80-ProPheAspProMetGlyTrp-86 115-GlyArgLeuTyrArgThrPheSerAsn-123 164-ThrLysArgGlySerArgLeu-170 207-SerThrSerThrLeuArgLysLeuMetArgProSerThr-219 Antigenic Index - Jameson-Wolf 10-MetArgSerAlaProSerMetVal-17 29-PheSerIleArgArgSerSerAlaCysTrpThrArgArgSerAspSerLeuSer-46 52-SerSerAsnAsnAsnIle-57 67-MetAlaThrArgCysArgCysProProAspLysLeuLeuPro-80 82-AspProMetGlyTrpCysSerProSerGlyGluLeuSer-94 104-ArgAlaAsnArgThrSerAlaSerProAlaSerGlyArgLeuTyr-118 121-PheSerAsnArgValSerSerAsnArgAsnThrSerTrpGluThrArgAlaAsnTrpAlaArgArgGlnSer SerLeu-146 158-LeuProAlaAspGlySerThrLysArgGlySerArgLeuThrThr-172 176-ProLeuProGluArgProThrArgAlaThrArgSerProCysLeu-190 194-LeuLysLeuSerArg-198 200-LeuMetProSerGluArgTyrSerThrSerThrLeuArgLysLeuMetArgProSerThrArgCysGlyAla -223 229-CysSerGlyGlyValSerArgAsnAlaHisThrProSerAlaAlaArgAsn-245 Hydrophilic Regions - Hopp-Woods 29-PheSerIleArgArgSerSer-35 38-TrpThrArgArgSerAspSerLeu-45 67-MetAlaThrArgCysArgCysProProAspLys-77 90-SerGlyGluLeuSer-94 104-ArgAlaAsnArgThrSerAla-llO 124-ArgValSerSerAsnArgAsnThrSerTrpGluThr-135 137-AlaAsnTrpAlaArgArgGlnSerSer-145 161-AspGlySerThrLysArgGlySerArg-169 176-ProLeuProGluArgProThrArgAlaThrArg-186 194-LeuLysLeuSerArg-198 200-LeuMetProSerGluArgTyrSer-207 210-ThrLeuArgLysLeuMetArgProSerThrArgCys-221 232-GlyValSerArgAsnAlaHis-238 277 AMPHI Regions - AMPHI 39-GlyIleAlaValPheGluValValGlyGlyLeuLeuAspPheValLeu-54 70-CysProAsnGluValValAspValPheTyrThr-80 87-AlaPheAspAlaValGlyAspPheAlaGluTyrGlyArgAlaValAspAlaAlaAspLeuLeuGluIleGlyL ysLeuGlyTyrPheHis-116 180-AlaValGlyValValAlaValAla-187 Antigenic Index - Jameson-Wolf 2-ProArgPheGluAspLysLeuValGlyArgGlnGlyGluGlyGlyVal-17 60-ValGlyAspGlyValAlaVal-66 68-ArgPheCysProAsnGluVal-74 95-AlaGluTyrGlyArgAlaValAspAla-103 118-ValGluProAspPheProAlaGlnThrProArgAlaGluGlyGly-132 138-PheAspLysAlaAspValVal-144 156-ValGluIleGluVal-160 164-GlyGlySerGlyLeuGluGlyAspLeu-172 196-LeuAspValGlyGlyLysProArgLeuGlyAla-206 208-CysAlaGlnAlaGlyGlyGly-214 219-GlyThrAspPheHis-223 226-GlyLeuAspAspGlyAla-231 239-LeuGlnPheGluAspAspLeuLeuGluGlyLysHisGlyLeu-252 Hydrophilic Regions - Hopp-Woods 2-ProArgPheGluAspLysLeuValGlyArgGlnGlyGlu-14 95-AlaGluTyrGlyArgAlaValAspAla-103 118-ValGluProAspPhe-122 126-ThrProArgAlaGluGly-131 138-PheAspLysAlaAspValVal-144 156-ValGluIleGluVal-160 167-GlyLeuGluGlyAspLeu-172 198-ValGlyGlyLysProArgLeuGlyAla-206 226-GlyLeuAspAspGlyAla-231 239-LeuGlnPheGluAspAspLeuLeuGluGlyLysHisGlyLeu-252 278 AMPHI Regions - AMPHI 7-GlyAlaIlePheSerIleGly-13 20-IleGlyProLeuProSerIleGlyArg-28 42-ThrGlyThrSerLys-46 101-ArgThrIleProSerValThrGluIle-109 123-PheSerIleLeuAlaLeuIleLysSerLeuIleSer-134 157-LeuTyrArgGlnIleGlnAsnLeuIleThrHisPheAsnPheTyrAlaAla-173 189-GluThrLeuIleGlnHisLeuHisGlnLeuAlaAsp-200 Antigenic Index - Jameson-Wolf 25-SerIleGlyArgProAsnAlaSerThrThrArgProThrSerSerArgProThrGlyThrSerLysIleArgP ro-49 63-SerProAsnThrThrAlaProThrGluSerArgSerArgPheIleAla-78 80-ProLysValLeuProGlyAsnSerSerIle-89 93-IleAlaSerAspLysProTrpMetArg-101 117-SerAlaPheThrAspArgPheSer-124 146-ArgHisSerArgValGlnGlyThr-153 178-PheAspPheAspArgAspPhe-184 209-ThrValAsnAspGlyArgPheAspMetValGlu-219 Hydrophilic Regions - Hopp-Woods 27-GlyArgProAsnAlaSerThrThrArgProThrSerSerArgProThrGlyThrSerLysIleArgPro-49 68-AlaProThrGluSerArgSerArgPheIleAla-78 93-IleAlaSerAspLysProTrp-99 146-ArgHisSerArgValGln-151 178-PheAspPheAspArgAspPhe-184 211-AsnAspGlyArgPheAspMetValGlu-219 279 AMPHI Regions - AMPHI 6-GlyCysLeuIleSerThr-ll 13-PheArgAlaSerAla-17 47-AlaAlaAlaMetAlaArgProThrAla-55 Antigenic Index - Jameson-Wolf 28-GlnTrpGluGlyThrAspThrGlySerGlyArgAlaArgLeuAla-42 64-CysProGlyGluLeuLysLeuThr-71 88-CysSerSerSerLysProArgIle-95 101-ThrProCysGlyThrAlaAspCysIleSerSerAlaArgArgArgThrΞerLeu-118 Hydrophilic Regions - Hopp-Woods 29-TrpGluGlyThrAspThrGlySerGlyArgAlaArgLeuAla-42 66-GlyGluLeuLysLeu-70 89-SerSerSerLysProArgIle-95 110-SerSerAlaArgArgArgThrSerLeu-118 280 AMPHI Regions - AMPHI 27-SerPheSerIleLeuGlyAspValAlaLys-36 64-AspIleLysLysIleArgSerAla-71 85-AspValGlnArgAlaValLys-91 97-TyrThrGluAlaThrLysGlyIleGlnProLeuLys-108 146-AlaTyrAlaGlnAsnValAlaLysAlaLeuIleLys-157 233-ValAlaAlaIleIleArgGlnIleLys-241 243-GluGlyIleLysAlaValPheThrGlu-251 254-LysAspThrArgMetValAspArgIleAlaLysGluThr-266 274-LeuTyrSerAspAlaLeuGlyAsnAlaProAlaAspThrTyrIle-288 Antigenic Index - Jameson-Wolf 38-IleGlyGlyGluArgValSer-44 51-AlaAsnGlnAspThrHis-56 61-ThrSerGlyAspIleLysLysIleArgSerAlaLys-72 82-GluAlaAlaAspValGlnArgAlaValLysGlnSerLysValSerTyrThrGluAlaThrLysGlyIleGln- 105 107-LeuLysAlaGluGluGluGlyGlyHisHisHisAspHisAspHisAspHisGluGlyHisHisHisAspHis GlyGluTyrAspProHisValTrpAsnAspPro-141 155-LeuIleLysAlaAspProGluGlyLysValTyrTyr-166 176-GlnLeuLysLysLeuHisSerAspAla-184 192-ProAlaAlaLysArgLysValLeuThr-200 208-MetGlyLysArgTyrHis-213 218-AlaProGlnGlyValSerSerGluAlaGluProSerAlaLysGln-232 238-ArgGlnIleLysArgGluGlyIle-245 251-GluAsnIleLysAspThrArgMetValAspArgIleAlaLysGluThrGlyVal-268 270-ValSerGlyLysLeuTyrSer-276 282-AlaProAlaAspThr-286 29i-τyrArgHisAsnIle-295 Hydrophilic Regions - Hopp-Woods 38-IleGlyGlyGluArgValSer-44 63-GlyAspIleLysLysIleArgSerAlaLys-72 82-GluAlaAlaAspValGlnArgAlaValLysGlnSerLys-94 99-GluAlaThrLysGly-103 107-LeuLysAlaGluGluGluGlyGlyHisHisHisAspHisAspHisAspHisGluGlyHisHisHisAspHis GlyGluTyrAsp-134 155-LeuIleLysAlaAspProGluGly-162 176-GlnLeuLysLysLeuHisSerAspAla-184 192-ProAlaAlaLysArgLysValLeuThr-200 222-ValSerSerGluAlaGluProSerAlaLysGln-232 238-ArgGlnIleLysArgGluGlyIle-245 251-GluAsnIleLysAspThrArgMetValAspArgIleAlaLysGluThrGlyVal-268 281-2 AMPHI Regions - AMPHI 62-AlaAlaGlyMetLeuMetAlaLeuLeuAlaGlyLeuValSerArgPhe-77 126-LeuGlnLeuIleAlaAlaValSerSerLeuThr-136 179-LeuValSerGlyPheGlnAlaLeuGlyThrLeuMetSerVal-192 205-TrpAlaLysHisMet-209 216-SerValLeuThrAlaLeuLeuCysGly-224 Antigenic Index - Jameson-Wolf 25-ArgArgMetSerLeu-29 78-ThrThrLeuLysGluAspAlaAsn-85 102-SerLysAsnGlySerSerVal-108 159-SerValGlyGlyLysGlyGly-165 236-IleProSerGlyPro-240 256-LeuGlyLysGluGlyGlyIle-262 270-HisArgHisHisThrThr-275 Hydrophilic Regions - Hopp-Woods 25-ArgArgMetSerLeu-29 78-ThrThrLeuLysGluAspAlaAsn-85 103-LysAsnGlySerSer-107 256-LeuGlyLysGluGlyGlyIle-262 270-HisArgHisHisThr-274 282 AMPHI Regions - AMPHI 10-LeuIleValAlaPheLeuValLeuIleAsnProPheSerAlaLeu-24 50-ValPheAlaValIleAlaValPheAlaLeuIleGlyGlyThrLeu-64 112-ArgProAlaArgAsn-116 176-ValSerArgLeuLeu-180 186-ThrIleLeuAsnArgIleMetGlyMet-194 Antigenic Index - Jameson-Wolf 31-ThrAsnGlyHisSerThrLysGluArgArgLysValAlaArg-44 92-AsnGlyAsnAspAsnProAlaLysGlnAsnLeuGlyAlaGlnProGluThrGlyGlnAlaArgProAlaArgA snAlaGly-118 Hydrophilic Regions - Hopp-Woods 34-HisSerThrLysGluArgArgLysValAlaArg-44 92-AsnGlyAsnAspAsnProAlaLysGlnAsnLeu-102 104-AlaGlnProGluThrGlyGlnAlaArgProAlaArgAsn-116 283 AMPHI Regions - AMPHI ll-ThrLeuAlaSerPheLeuPro-17 32-GlyGlyAsnSerTyrSerAspValProLysGlnLeuHis-44 67-AlaAspAlaGlyLysArgThr-73 Antigenic Index - Jameson-WoIf 28-TrpLysAspGlyGlyGlyAsnSerTyrSerAspValProLysGlnLeuHisProAspGlnSerGln-49 53-LeuArgThrArgGlnThrLysProAlaValLysProAlaGlnAlaAspAlaGlyLysArgThrAspGlyAlaA laGlnGluAsnAsnProAspThrAlaGluLysAsnArgGlnLeuGluGluGluLysLysArglleAlaGluThrGl uArgGlnAsnLysGluGluAsnCysArgIleSerLysMetAsnLeu-117 121-GlyAsnSerAsnAlaLysAsnLysAspAspLeuIleArgLysTyrAsnAsnAlaValAsnLysTyrCysArg -144 Hydrophilic Regions - Hopp-Woods 35-SerTyrSerAspValProLys-41 43-LeuHisProAspGlnSerGln-49 53-LeuArgThrArgGlnThrLysProAlaValLysProAlaGlnAlaAspAlaGlyLysArgThrAspGlyAlaA laGlnGluAsnAsnProAspThrAlaGluLysAsnArgGlnLeuGluGluGluLysLysArglleAlaGluThrGl uArgGlnAsnLysGluGluAsnCysArgIleSerLysMetAsnLeu-117 123-SerAsnAlaLysAsnLysAspAspLeuIleArgLysTyrAsn-136 284 AMPHI Regions - AMPHI 43-GluAlaPheAlaGlyPhePheGluThrVal-52 61-ThrPheAlaAlaArgPhe-66 125-ValAspPheAspValPhe-130 154-ValValPheArgLeuPheArgGlnValValValAsp-165 174-AspThrAlaCysGlyAsnIleGlyGly-182 186-PheAlaAlaAlaPheThrGlnIleHisGln-195 216-PheValGlnPheIleArgAsnAspPheGlyHisGly-227 277-PheArgValPheGlyGlnPheAlaArgGlnPheAla-288 307-CysPheHisAspGlyPheAspValValAspLys-317 342-LeuHisGlnValHisGlnThrAla-349 352-GlyAspAsnGlnIleAspArgPheAlaGln-361 372-AlaAspAspAlaAspGlyAla-378 405-GlnSerThrArgAlaPheAlaArgPhePheAlaAlaPheGlyGlnPheLeuGlnSer-423 Antigenic Index - Jameson-Wolf l-MetProSerGluThrArgAsnArgPhe-9 109-PheAspGlyGlnPhe-113 132-HisPheGlyLysArgAsnArgAsnThrArgAla-142 147-GlyAlaProAspAlaVal-152 166-AsnValGlyAsnGlyArgTyrValAspThrAlaCysGlyAsnIleGlyGlyAsnGlnAsnPhe-186 220-IleArgAsnAspPheGlyHisGlyPheGlyGlyArgGluAsnHisAla-235 273-AspPheAspAspPheArg-278 286-GlnPheAlaAspArgAlaValProSerGlyGlyGluGlnGlnSer-300 303-ValAlaArgArgCysPheHisAspGlyPheAspValValAspLysAlaHis-319 347-GlnThrAlaArgArgGlyAspAsnGlnIleAspArgPheAlaGlnGlyThrGlyLeuValAlaGluArgArg AlaAlaAspAspAlaAspGlyAlaGlu-379 398-PheAlaGlyArgGlyGlnHisGlnSerThrArgAla-409 Hydrophilic Regions - Hopp-Woods l-MetProSerGluThrArgAsnArgPhe-9 134-GlyLysArgAsnArgAsnThrArgAla-142 229-GlyGlyArgGluAsnHisAla-235 286-GlnPheAlaAspArgAlaValProSerGlyGlyGluGlnGln-299 313-AspValValAspLysAlaHis-319 347-GlnThrAlaArgArgGlyAspAsnGlnIleAspArgPheAla-360 366-ValAlaGluArgArgAlaAlaAspAspAlaAspGlyAlaGlu-379 402-GlyGlnHisGlnSer-406 285-1 AMPHI Regions - AMPHI 15-ValCysPheLeuGly-19 34-GlnIleProSerTrp-38 50-GlyThrLeuLeuAspGlyPheAsp-57 116-SerLeuProAspSerIleAspLeuPro-124 208-HisSerThrAlaArg-212 240-HisProPheAlaGluSerLeuAspLysThrLeuGluGluValLeu-254 266-ValProSerLeuPro-270 280-AlaIleProSerPheSerAsp-286 313 -GlnValLeuGlyGly-317 592-IleGlyLysAlaAlaAspIle-598 609-ProAspThrSerArg-613 671-GlyI1eAsnArgGluLeuThrArgTrp-679 747-IleAlaGluLeuHisAsnPhePheLysProProPhe-758 776-AlaArgGlyTyrLeu-780 836-PheGlyGlyAsnMetAlaAsn-842 848-ArgIleThrAlaSerLeu-853 855-AspLeuGlyAlaLeu-859 868-GlnAsnIleThrGlySerLeuAsnAlaAla-877 955-GlySerIleAlaAsp-959 1008-ThrAlaGluLeu-1012 1061-ValThrGlyMetIleLys-1066 1135-SerGlyGlySerValArgGlyValGlyThrValArg-1146 1165-ThrValSerPheValGlyProLeuAsn-1173 1190-AlaGlyValGluIleLeuGlySerLeuAsn-1199 1244-LeuAlaGlyGlnIle-1248 1305-ValLysLeuIleTyrArgLeuThrArgAlaIleGlnAlaValAlaArgIleGlySer-1323 Antigenic Index - Jameson-Wolf 43-IleSerSerGlnAsnLeuLysGlyThrLeuLeuAspGlyPheAspGlyAspAsnTrpSerIleGluThrGluG lyAlaAspLeuLysIleSerArg-74 80-LysProSerGluLeuMetArgArgSerLeuHis-90 104-LysProThrProProLysGluGluArgProProLeuSerLeuProAspSerIleAsp-122 130-AspArgPheGluThrGlyLysIleSerMetGlyLysAlaPheAspLysGlnThrValTyr-149 151-GluArgLeuAspAlaSerTyrArgTyrAspArgLysGlyHisArgLeuAspLeuLysAlaAlaAspThrPro TrpSerSerSerSerGlyAlaAla-182 185-GlyLeuLysLysProPheAla-191 198-ThrLysGlyGlyLeuGluGlyLysThrIle-207 209-SerThrAlaArgLeuSerGlySerLeuLysAspValArgAla-222 224-LeuAlaIleAspGlyGlyAsnIleArgLeuSerGlyLysSer-237 244-GluSerLeuAspLysThrLeuGlu-251 268-SerLeuProAspAla-272 292-GlySerLeuAspLeuGluAsnThrLys-300 302-GlyPheAlaAspArgAsnGlyIleProVal-311 320-IleArgGlnAspGlyThrVal-326 337-GlyArgGlyGlyIleArgLeuSerGlyLysIleAspThrGluLysAspIleLeu-354 362-SerValGlyAlaGluAspValLeu-369 372-AlaPheLysGlyArgLeuAspGlySerIle-381 387-ThrAlaSerProLysIle-392 400-ThrAlaArgThrAspGlySerLeu-407 411-SerAspProAlaAsnGlyGlnArgLysLeuVal-421 430-GlyGlnGlySerLeuThr-435 42-LeuPheLysAspArgLeuLeuLysLeuAspIleArgSerArgAlaPheAspProSerArgIleAspProGln Leu-466 480-GluLeuAlaLysGluLysPheThrGlyLys-489 508-IleValTyrGluSerArgHisLeuProArgAlaAlaVal-520 522-LeuArgLeuGlyArgAsnIleIleLysThrAspGlyGlyPheGlyLysLysGlyAspArgLeuAsn-543 548-AlaProAspLeuSerArgPheGly-555 563-AsnValArgGlyHisLeuSerGlyAspLeuAspGlyGlylleArgThrPheGluThrAspLeuSerGlyAla Ala-587 594-LysAlaAlaAspIleArgSer-600 605-LeuLysGlySerProAspThrSerArgProIleArgAlaAspIleLysGlySerArgLeuSerLeuSerGly Gly-629 634-AspThrAlaAspLeuMetLeuAspGlyThrGlyVal-645 647-HisArgIleArgThr-651 656-ThrLeuAspGlyLysProPheLysPheAspLeuAspAlaSerGlyGlyIleAsnArgGluLeuThrArgTrp LysGlySerIle-683 696-LeuGlnAsnArgMetThrLeu-702 704-AlaGlyAlaGluArgValAla-710 729-SerTrpAspLysLysThrGlyIleSerAlaLysGlyGlyAla-742 764-LeuAsnGlyAspTrp-768 772-TyrGlyArgAsnAlaArgGly-778 782-IleSerArgGlnSerGlyAspAlaValLeu-791 803 -SerLeuLysThrArgPheGlnAsnAspArgl1eGly-814 817-LeuAspGlyGlyAlaArgPheGlyArgIleAsnAla-828 844-ProLeuGlyGlyArgIleThr-850 882-GlyArgValGlySerProSerVal-889 893-ValAsnGlySerSerAsnTyrGlyLysIleAsnGly-904 908-ValGlyGlnSerArgSerPheAspThrAlaProLeuGlyGlyArgLeuAsn-924 941-GlnThrValLysGlySerLeu-947 956-SerIleAlaAspProHisLeuGlyGly-964 966-IleAsnGlyAspLysLeuTyrTyrArgAsnGlnThr-977 982-LeuAspAsnGlySerLeuArg-988 99l-IleAlaGlyArgLysTrpVal-997 1001LeuLysPheArgHisGluGlyThrAlaGluLeuSerGly-1013 1015-ValGlyMetGluAsnSerGlyProAspValAspIle-1026 1031-AspLysTyrArgIleLeuSerArgProAsnArgArgLeuThr-1044 1047-GlyAsnThrArgLeuArgTyrSerProGlnLysGlyIle-1059 1065-IleLysThrAspGlnGlyLeuPheGlySerGlnLysSerSerMetProSerValGlyAspAspVal-1086 1091-GluValLysLysGluAlaAla-1097 1109-AspLeuAsnAspGlyIleArg-1115 1134-GlnSerGlyGlySerValArgGlyValGly-1143 1146-ArgValIleLysGlyArgTyrLysAlaTyrGlyGlnAspLeuAspIle ThrLysGlyThr-1165 1171-ProLeuAsnAspProAsnLeuAsnl1eArgAlaGluArgArgLeuSerProValGly-1189 1197-SerLeuAsnSerProArgIle-1203 1207-AlaAsnGluProMetSerGluLysAspLysLeu-1217 1225-AlaGlySerGlySerSerGlyAspAsnAlaAla-1235 1246-GlyGlnIleAsnAspArgIleGlyLeu-1254 1256-AspAspLeuGlyPheThrSerLysArgSerArgAsnAlaGlnThrGlyGluLeuAsnProAlaGlu-1277 1283-GlyLysGlnLeuThrGlyLys-1289 1299-SerSerAlaGluGlnSerVal-1305 1321-IleGlySerArgSerSerGlyGlyGluLeu-1330 1335-ArgPheAspArgPheSerGlySerAspLysLysAspSerAlaGlyAsnGlyLysGlyLys-1354 Hydrophilic Regions - Hopp-Woods 56-PheAspGlyAspAsnTrpSerIleGluThrGluGlyAlaAspLeuLysIleSerArg-74 83-GluLeuMetArgArgSerLeuHis-90 105-ProThrProProLysGluGluArgProPro-114 130-AspArgPheGluThrGlyLys-136 141-LysAlaPheAspLys-145 151-GluArgLeuAspAla-155 157-TyrArgTyrAspArgLysGlyHisArgLeuAspLeuLysAlaAlaAsp-172 200-GlyGlyLeuGluGlyLysThrIle-207 215-GlySerLeuLysAspValArgAla-222 244-GluSerLeuAspLysThrLeuGlu-251 292-GlySerLeuAspLeuGluAsnThrLys-300 302-GlyPheAlaAspArgAsnGlyIlePro-310 320-IleArgGlnAspGly-324 343-LeuSerGlyLysIleAspThrGluLysAspIleLeu-354 364-GlyAlaGluAspValLeu-369 373 -PheLysGlyArgLeuAspGly-379 401-AlaArgThrAspGly-405 412-AspProAlaAsnGlyGlnArgLysLeuVal-421 442-LeuPheLysAspArgLeuLeuLysLeuAspIleArgSerArgAlaPheAspProSerArgIleAspPro-46 4 480-GluLeuAlaLysGluLysPheThrGly-488 508-IleValTyrGluSerArgHisLeuPro-516 522-LeuArgLeuGlyArgAsnIleIleLysThrAspGlyGlyPheGlyLysLysGlyAspArgLeuAsn-543 570-GlyAspLeuAspGlyGlyIleArgThrPheGluThrAspLeuSerGlyAlaAla-587 594-LysAlaAlaAspIleArgSer-600 607-GlySerProAspThrSerArgProIleArgAlaAspIleLysGlySerArgLeuSerLeu-626 634-AspThrAlaAspLeuMetLeu-640 647-HisArgIleArgThr-651 657-LeuAspGlyLysProPheLysPheAspLeuAspAla-668 670-GlyGlyIleAsnArgGluLeuThrArgTrpLysGly-681 704-AlaGlyAlaGluArgValAla-710 729-SerTrpAspLysLysThrGlyIleSerAlaLysGlyGlyAla-742 783-SerArgGlnSerGly-787 806-ThrArgPheGlnAsnAspArgIle-813 819-GlyGlyAlaArgPheGlyArgIleAsnAla-828 1001-LeuLysPheArgHisGluGlyThrAlaGluLeu-lOll 1015-ValGlyMetGluAsnSerGlyProAspValAspIle-1026 1031-AspLysTyrArglleLeuSerArgProAsnArgArgLeuThr-1044 1049-ThrArgLeuArgTyrSerPro-1055 1065-IleLysThrAspGln-1069 1075-GlnLysSerSerMet-1079 1081-SerValGlyAspAsp-1085 1091-GluValLysLysGluAlaAla-1097 1109-AspLeuAsnAspGlyIleArg-1115 1146-ArgValIleLysGlyArgTyrLysAlaTyrGlyGlnAspLeuAspI1eThrLys-1163 1179-IleArgAlaGluArgArgLeuSer-1186 1209-GluProMetSerGluLysAspLysLeu-1217 1225-AlaGlySerGlySerSerGlyAspAsnAlaAla-1235 1248-IleAsnAspArgIleGlyLeu-1254 1259-GlyPheThrSerLysArgSerArgAsnAlaGlnThrGlyGluLeuAsn Pro-1275 1300-SerAlaGluGlnSerVal-1305 1321-IleGlySerArgSerSerGlyGly-1328 1335-ArgPheAspArgPheSerGlySerAspLysLysAspSerAlaGlyAsnGlyLysGlyLys-1354 286 AMPHI Regions - AMPHI 69-GluIleLysAspMetVal-74 102-ProAspAsnValLysThr-107 145-ValAlaIleLeuGlyAsp-150 157-LeuAlaGluTyrTyrArgAsnAlaLeuGluAsnTrpGlnGlnProValGlySer-174 198-ProLeuAlaLysLeuGlyAsnThr-205 238-ThrGlnArgTyrProGluGlnIleValSerGlyLeuAlaArgPhe-252 326-AspTyrTyrAsnLeuPheAsnLys-333 354-IleSerGlnProArg-358 375-ThrThrGlnAsnLeu-379 428-ThrAlaSerTrpLysArgGlnLeuLeu-436 455-ThrLeuGlyThrPheLeu-460 513-GlyAlaSerSerVal-517 555-LeuSerGlyAlaValPheHisAspMetGlyAspAlaAlaAlaAsn-569 584-ArgTrpPheSerProLeu-589 Antigenic Index - Jameson-Wolf 1-MetHisAspThrArgThrMetMet-8 30-AlaAspLeuSerGluAsnLysAla-37 43-PheLysAsnLysSerProAspThrGluSerValLysLeuLysProLysPheProVal-61 64-AspThrGlnAspSerGluIleLysAspMetValGluGluHisLeu-78 83-GlnGlnGlnGluGluValLeuAspLysGluGlnThr-94 97-LeuAlaGluGluAlaProAspAsnValLysThrMetLeuArgSerLysGlyTyrPheSerSerLysValSerL euThrGluLysAspGlyAla-127 133-ThrProGlyProArgThrLysIle-140 151-IleLeuSerAspGlyAsnLeuAlaGluTyrTyrArgAsnAlaLeuGluAsnTrpGln-169 172-ValGlySerAspPheAspGlnAspSerTrpGluAsnSerLysThrSerVal-188 192-ValThrArgLysAlaTyrPro-198 208-AlaValAsnProAspThrAlaThr-215 223-AspSerGlyArgProIleAla-229 234-GluIleThrGlyThrGlnArgTyrProGluGlnIle-245 252-PheGlnProGlyMetProTyrAspLeu-260 270-LeuGluGlnAsnGlyHisTyrSerGly-278 283-AlaAspPheAspArgLeuGlnGlyAspArgValProVal-295 298-SerValThrGluValLysArgHisLysLeuGluThrGlyIleArgLeuAspSerGluTyrGlyLeuGlyGly -321 342-AspMetAspLysTyrGluThr-348 355-SerGlnProArgAsnTyrArgGlyAsnTyrTrp-365 368-AsnValSerTyrAsnArgSerThrThrGlnAsnLeuGluLysArgAlaPheSerGlyGly-387 390-TyrValArgAspArgAlaGlyIleAspAlaArgLeuGly-402 405-PheLeuAlaGluGlyArgLysIleProGlySerAla-416 430-SerTrpLysArgGlnLeu-435 441-HisProGluAsnGlyHisTyrLeuAspGlyLysIle-452 468-ThrSerAlaArgAlaGly-473 476-PheThrProGluAsnLysLysLeu-483 496-ValAlaArgAspAsnAlaAspValProSer-505 509-PheArgSerGlyGlyAlaSerSerValArgGlyTyrGluLeuAspSer-524 534-ValLeuProGluArgAlaLeu-540 562-AspMetGlyAspAla-566 568-AlaAsnPheLysArgMetLysLeuLysHisGlySerGlyLeu-581 598-TyrGlyHisSerAspLysLysIleArg-606 Hydrophilic Regions - Hopp-Woods 1-MetHisAspThrArgThrMetMet-8 30-AlaAspLeuSerGluAsnLysAla-37 44-LysAsnLysSerProAspThrGluSerValLysLeuLysProLysPhe-59 64-AspThrGlnAspSerGluIleLysAspMetValGluGluHisLeu-78 84-GlnGlnGluGluValLeuAspLysGluGlnThr-94 97-LeuAlaGluGluAlaProAspAsnValLysThrMetLeuArgSer-lll 119-ValSerLeuThrGluLysAspGlyAla-127 134-ProGlyProArgThrLysIle-140 174-SerAspPheAspGlnAspSerTrpGluAsnSerLysThr-186 192-ValThrArgLysAlaTyrPro-198 209-ValAsnProAspThrAlaThr-215 239-GlnArgTyrProGlu-243 283-AlaAspPheAspArgLeuGlnGlyAspArgValProVal-295 298-SerValThrGluValLysArgHisLysLeuGluThrGlyIleArgLeuAspSerGluTyr-317 342-AspMetAspLysTyrGluThr-348 373-ArgSerThrThrGlnAsnLeuGluLysArgAlaPhe-384 391-ValArgAspArgAla395GlyIleAspAlaArgLeuGly-402 405-PheLeuAlaGluGlyArgLysIlePro-413 478-ProGluAsnLysLysLeu-483 496-ValAlaArgAspAsnAlaAspVal-503 518-ArgGlyTyrGluLeuAspSer-524 534-ValLeuProGluArgAlaLeu-540 562-AspMetGlyAspAla-566 568-AlaAsnPheLysArgMetLysLeuLysHis-577 600-HisSerAspLysLysIleArg-606 287 AMPHI Regions - AMPHI 29-LysSerAlaAspThrLeuSerLysProAlaAla-39 68-GlySerGlnAspMet-72 131-AlaThrAspAlaGlyGluSerSerGlnProAlaAsnGlnProAspMetAlaAsnAlaAlaAspGlyMet-15 3 164-AsnAlaGlyAsnThrAlaAlaGlnGlyAlaAsnGlnAlaGly-177 246-PheGluLysLeuSerAspAlaAspLysIleSer snTyrLys-259 291-ProThrSerPheAlaArgPheArgArgSerAlaArg-302 410-LysSerValAspGlyIleIleAspSer-418 437-GlyPheLysGlyThrTrpThr-443 450-ValSerGlyLysPheTyr-455 Antigenic Index - Jameson-Wolf 18-CysGlyGlyGlyGlyGlyGlySerProAspValLysSerAlaAspThrLeuSerLysProAla-38 42-ValSerGluLysGluThrGluAlaLysGluAspAlaProGlnAlaGlySerGlnGlyGlnGlyAlaProSerA laGlnGlySerGlnAspMet-72 74-AlaValSerGluGluAsnThrGlyAsnGlyGlyAlaValThrAlaAspAsnProLysAsnGluAspGluValA laGlnAsnAspMetProGlnAsnAlaAlaGlyThrAspSerSerThrProAsnHisThrProAspProAsnMet-1 22 126-AsnMetGluAsnGlnAlaThrAspAlaGlyGluSerSerGlnProAlaAsnGlnProAspMetAlaAsnAla AlaAspGlyMetGlnGlyAspAspProSerAlaGlyGlyGlnAsnAlaGlyAsnThrAlaAlaGlnGlyAlaAsnG InAlaGlyAsnAsnGlnAlaAlaGlySerSerAspProIleProAlaSerAsnProAlaProAlaAsnGlyGlySe rAsnPheGlyArgValAspLeuAlaAsn-209 214-AspGlyProSerGlnAsn-219 223-ThrHisCysLysGlyAspSerCysSerGlyAsnAsnPheLeuAspGluGluValGlnLeuLysSerGluPhe GluLysLeuSerAspAlaAspLysIleSerAsnTyrLysLysAspGlyLysAsnAspLysPhe-267 287-TyrLysProLysProThrSerPheAlaArgPheArgArgSerAlaArgSerArgArgSerLeuProAla-30 9 321-ThrLeuIleValAspGlyGluAla-328 340-AlaProGluGlyAsnTyrArgTyrLeu-348 351-GlyAlaGluLysLeuProGlyGlySerTyr-360 364-ValGlnGlyGluProAlaLysGlyGluMet-373 388-HisThrGluAsnGlyArgProTyrProThrArgGlyArgPheAlaAla-403 405-ValAspPheGlySerLysSerValAspGlyIleIleAspSerGlyAspAspLeuHisMetGlyThrGlnLys PheLysAlaAlaIleAspGlyAsnGlyPheLysGlyThrTrpThrGluAsnGlySerGlyAspValSerGly-452 454-PheTyrGlyProAlaGlyGluGluValAlaGlyLysTyrSerTyrArgProThrAspAlaGluLysGlyGly Phe-478 482-AlaGlyLysLysGluGlnAsp-488 Hydrophilic Regions - Hopp-Woods 22-GlyGlyGlySerProAspValLysSerAlaAspThrLeuSerLysProAla-38 42-ValSerGluLysGluThrGluAlaLysGluAspAlaProGln-55 57-GlySerGlnGlyGlnGly-62 67-GlnGlySerGlnAsp-71 74-AlaValSerGluGluAsnThrGly-81 86-ValThrAlaAspAsnProLysAsnGluAspGluValAlaGlnAsnAspMetProGln-104 107-AlaGlyThrAspSerSerThr-113 127-MetGluAsnGlnAlaThrAspAlaGlyGluSerSerGlnProAlaAsnGlnProAspMetAlaAsnAlaAla AspGlyMetGlnGlyAspAspProSerAlaGly-161 182-AlaGlySerSerAspProIlePro-189 225-CysLysGlyAspSerCysSer-231 235-PheLeuAspGluGluValGlnLeuLysSerGluPheGluLysLeuSerAspAlaAspLysIleSerAsnTyr LysLysAspGlyLysAsnAspLysPhe-267 295-AlaArgPheArgArgSerAlaArgSerArgArgSerLeuPro-308 322-LeuIleValAspGlyGluAla-328 351-GlyAlaGluLysLeuPro-356 364-ValGlnGlyGluProAlaLysGlyGluMet-373 390-GluAsnGlyArgProTyrProThrArgGlyArgPheAlaAla-403 405-ValAspPheGlySerLysSerValAspGlyIleIleAspSerGlyAspAspLeuHis-423 427-GlnLysPheLysAlaAlaIleAsp-434 446-GlySerGlyAspValΞerGly-452 458-AlaGlyGluGluValAlaGly-464 466-TyrSerTyrArgProThrAspAlaGluLysGlyGly-477 482-AlaGlyLysLysGluGlnAsp-488 288 AMPHI Regions - AMPHI 7-ValSerArgValLeu-ll 54-IleValThrLysCysAla-59 61-ArgProTyrArgThrPheSerProLeuProVal-71 97-HisSerThrLeuArg-101 150-AlaLeuPheGlnAlaGlyPheAsp-157 Antigenic Index - Jameson-Wolf 2-HisThrGlyGlnAla-6 28-AsnLeuProGluArgSerAlaGlySer-36 58-CysAlaValArgProTyrArgThrPheSerPro-68 72-LeuProLysGlnProSerAla-78 89-LeuProArgProAlaValAsnArgHisSerThrLeuArgSerProAspPheProProArgMet-109 113-IleArgGlyAspCysLeuPro-119 126-IleIleThrArgAsnThrLysMetProSerGluThrValGlnValSerAspGlyIleGlnProLys-147 155-GlyPheAspGluAlaVal-160 Hydrophilic Regions - Hopp-Woods 28-AsnLeuProGluArgSerAla-34 58-CysAlaValArgPro-62 98-SerThrLeuArgSerProAspPheProPro-107 113-IleArgGlyAspCys-117 126-IleIleThrArgAsnThrLysMetProSerGluThrValGlnVal-140 155-GlyPheAspGluAlaVal-160 292 AMPHI Regions - AMPHI 7-LysIleLeuThrProPheThrValLeuProLeu-17 40-GlyLysSerValAla-44 62-ValLeuSerValSerGlu-67 69-ProValLysGlyIleTyrGlu-75 110-GluArgAlaAlaAspLeu-115 124-ProLeuAspLysAlaIleLysGluValArgGly-134 150-PheCysLysArgLeuGluHisGluPheGluLysMetThrAspValThr-165 195-LysAlaTrpThrAspTrpMetArg-202 212-IleCysAspAsnProVal-217 Antigenic Index - Jameson-Wolf 1-MetLysThrLysLeu-5 23-ThrProValSerAsnAlaAsnAlaGluProAlaValLysAlaGluSerAlaGlyLysSerVal-43 47-LeuLysAlaArgLeuGluLysThrTyrSerAlaGlnAspLeuLys-61 66-SerGluThrProValLysGlyIle-73 85-TyrThrAspAlaGluGlyGlyTyr-92 99-IleAsnIleAspThrArgLysAsnLeuThrGluGluArgAlaAlaAspLeuAsnLys-117 124-ProLeuAspLysAlaIleLysGluValArgGlyAsnGlyLysLeuLysVal-140 142-ValPheSerAspProAspCysProPhe-150 152-LysArgLeuGluHisGluPheGluLysMetThrAsp-163 177-HisProAspAlaAlaArgLysAla-184 189-CysGlnProAspArgAlaLysAla-196 200-TrpMetArgLysGlyLysPheProVal-208 210-GlySerIleCysAspAsnProValAlaGluThrThrSerLeuGlyGlu-225 237-PheProAsnGlyArgSerGlnSerGlyTyrSerPro-248 250-ProGlnLeuGluGluIleIleArgLysAsnGln-260 Hydrophilic Regions - Hopp-Woods l-MetLysThrLysLeu-5 28-AlaAsnAlaGluProAlaValLysAlaGluSerAlaGlyLysSerVal-43 47-LeuLysAlaArgLeuGluLysThrTyrSer-56 99-IleAsnIleAspThrArgLysAsnLeuThrGluGluArgAlaAlaAspLeuAsnLys-117 124-ProLeuAspLysAlal1eLysGluValArgGlyAsnGlyLysLeuLys-139 144-SerAspProAspCysProPhe-150 152-LysArgLeuGluHisGluPheGluLysMetThrAsp-163 179-AspAlaAlaArgLysAla-184 190-GlnProAspArgAlaLysAla-196 200-TrpMetArgLysGlyLysPhe-206 240-GlyArgSerGlnSer-244 250-ProGlnLeuGluGluIleIleArgLysAsnGln-260 294 AMPHI Regions - AMPHI 27-ArgPheProAlaAlaPheArgArgTyrSerAla-37 45-LysProAlaAspThr-49 51-TrpHisArgValArgArgPheLysSerAsnArgArgMetArgGlyGlyLysProLeuLysLysProTyrArg- 74 84-ArgAlaTrpThrAlaLeuSerHisAsnIleAlaGluArgAlaArgGluSerProArgArgCysGlyLysArgT yrAlaAspIleGlyGly-113 132-TyrAlaValAlaHisIleValHisLeu-140 165-ValSerArgGluAlaArgArgGluVal-173 176-AlaMetSerTyrArg-180 206-SerIleLeuGlyGluProPheAlaThrSerPheGly-217 227-AlaPheSerValLeuAlaHisPhe-234 247-ThrValGlyTrpSerLysTyrIleHisAlaVal-257 Antigenic Index - Jameson-Wolf 20-ValValArgThrSerSerAsnArgPhe-28 32-PheArgArgTyrSerAlaPhe-38 43-PheProLysProAlaAspThrProTrpHisArgValArgArgPheLysSerAsnArgArgMetArgGlyGlyL ysProLeuLysLysProTyrArgProArgGlyGlyGlyCysArgCysArgArgAla-85 93-IleAlaGluArgAlaArgGluSerProArgArgCysGlyLysArgTyrAlaAspIleGlyGlyAspSerAspT hrIleArgIleArgValPheArgLeuGluHisArgMet-129 161-HisThrGlyArgValSerArgGluAlaArgArgGluValGluLysAlaMetSer-178 240-LysMetAlaArgSer-244 Hydrophilic Regions - Hopp-Woods 20-ValValArgThrSerSerAsnArg-27 50-ProTrpHisArgValArgArgPheLysSerAsnArgArgMetArgGlyGlyLysProLeuLysLysProTyrA rgProArgGlyGlyGlyCysArgCysArgArgAla-85 93-IleAlaGluArgAlaArgGluSerProArgArgCysGlyLysArgTyrAlaAspIleGlyGlyAspSerAspT hrIleArg-119 121-ArgValPheArgLeuGluHisArgMet-129 164-ArgValSerArgGluAlaArgArgGluValGluLysAlaMetSer-178 295 AMPHI Regions - AMPHI 79-PheArgGlnProArgArgIle-85 lll-ValGlnArgPhePheArgGlnPro-118 163-ValIleArgLysIleAlaAlaLeu-170 189-HisGlnGlnArgArgIleGlyLysThr-197 240-11eCysArgGlyThrSerGly-246 263-TyrIleIleLysProLeuGluHis-270 Antigenic Index - Jameson-Wolf 4-MetAlaArgHisAspAspGlnGlnArg-12 18-LeuP oArgArgGlnGln-23 36-AlaAlaAlaHisGlyAsnArgProAlaSerAspAlaPhePheLysLeuProArgGlnArgPheHisLeu-58 73-HisGlyCysArgAlaGlnPheArgGlnProArgArgIleArgLeu-87 89-LeuArgGlnThrProArgGlnArgSerGlyGlyArgThrAspGlnAlaAla-105 115-PheArgGlnProArgIleArgGlnLysGlnArgHisThrArgAlaProAla-131 136-ValGlyProAspPheGly-141 144-GlnAsnAlaGluHisArgAla-150 171-ArgIleGlyLysGlnAsnLeuArgGlyPheProProArgArgGlyHisLeuArgHisGlnGlnArgArgIle GlyLysThrProProGlnLeuAla-202 207-GlyGlyThrArgPheSerAspArgAsnGlyValTyrProAsnArgAlaGlyAsnGlyIleArgIleArgLeu -230 239-ProIleCysArgGlyThrSerGly-246 253-ProTyrProTyrArgArgLysGlnProGlnTyr-263 273-IleSerCysLysThrAsnAla-279 287-PheArgGlnArgAsnGlnIleSer-294 Hydrophilic Regions - Hopp-Woods 5-AlaArgHisAspAspGlnGlnArg-12 18-LeuProArgArgGlnGln-23 36-AlaAlaAlaHisGlyAsnArgProAlaSer-45 77-AlaGlnPheArgGlnProArgArgIleArgLeu-87 91-GlnThrProArgGlnArgSerGlyGlyArgThrAspGlnAlaAla-105 118-ProArgIleArgGlnLysGlnArgHisThrArg-128 146-AlaGluHisArgAla-150 171-ArgIleGlyLysGlnAsnLeu-177 180-PheProProArgArgGlyHisLeuArgHisGlnGlnArgArgIleGlyLysThrProPro-199 210-ArgPheSerAspArgAsnGly-216 226-IleArgIleArgLeu-230 239-ProIleCysArgGlyThr-244 255-ProTyrArgArgLysGlnPro-261 287-PheArgGlnArgAsnGlnIle-293 297 AMPHI Regions - AMPHI 35-ArgThrGluArgVal-39 69-GlnProGlyAspSerLeuAlaAspValLeuAla-79 86-AspGluIleAlaArgIleThrGluLysTyr-95 157-LeuProThrLeuArg-161 199-LeuLysGluGlyAspAla-204 272-LeuValTyrThrArgIleSerSer-279 333-HisAlaAsnGlyValGluThrLeuTyrAlaHisLeuSerAlaPheSer-348 Antigenic Index - Jameson-Wolf 8-AlaLysHisArgLysTyrAla-14 32-SerThrGluArgThrGluArgValArgProGlnArgValGluGlnAsnLeuProProLeuSerTrpGlyGlyS erGly-57 67-AlaValGlnProGlyAspSerLeuAla-75 78-LeuAlaArgSerGlyMetAlaArgAspGluIleAlaArgIleThrGluLysTyrGlyGlyGluAlaAspLeuA rgHisLeuArgAlaAspGlnSerVal-110 115-GlyGlyAspGlyGlyAlaArgGluVal-123 127-ThrAspGluAspGlyGluArgAsnLeuValAlaLeuGluLysLysGlyGlyIleTrpArgArgSerAlaSer GluAlaAspMetLysVal-156 167-ThrSerAlaArgGlySerLeuAlaArgAlaGluValProValGluIleArgGluSerLeuSer-187 194-PheSerLeuAspGlyLeuLysGluGlyAspAlaVal-205 228-GluValValLysGlyGlyThrArgHis-236 240-TyrTyrArgSerAspLysGluGlyGlyGlyGlyGlyAsnTyrTyrAspGluAspGlyLysValLeuGlnGlu LysGlyGlyPheAsn-268 276-ArgIleSerSerProPheGlyTyr-283 295-HisThrGlyIleAspTyrAla-301 303-ProGlnGlyThrProValArgAlaSerAlaAspGly-314 318-PheLysGlyArgLysGlyGlyTyrGly-326 333 -HisAlaAsnGlyValGlu-338 350-AlaGluGlyAsnValArgGlyGlyGlu-358 365-SerThrGlyArgSerThrGlyProHisLeu-374 376-TyrGluAlaArgIleAsnGlyGlnProValAsn-386 393-ProThrProGluLeuThrGlnAlaAspLysAlaAla-404 408-GlnLysGlnLysAlaAspAlaLeu-415 426-ValSerGlnSerAsp-430 Hydrophilic Regions - Hopp-Woods 8-AlaLysHisArgLysTyrAla-14 32-SerThrGluArgThrGluArgValArgProGlnArgValGluGlnAsn-47 68-ValGlnProGlyAspSerLeuAla-75 82-GlyMetAlaArgAspGluIleAlaArgIleThrGluLysTyrGlyGlyGluAlaAspLeuArgHisLeuArgA laAspGln-108 117-AspGlyGlyAlaArgGlu-122 127-ThrAspGluAspGlyGluArgAsnLeuValAlaLeuGluLysLysGlyGlyIleTrpArgArgSerAlaSer GluAlaAspMetLysVal-156 167-ThrSerAlaArgGlySerLeuAlaArgAlaGluValProValGluIleArgGluSerLeu-186 194-PheSerLeuAspGlyLeuLysGluGlyAspAlaVal-205 228-GluValValLysGlyGlyThrArg-235 242 -ArgSerAspLysGluGlyGlyGly-249 253-TyrTyrAspGluAspGlyLysValLeuGlnGluLysGlyGlyPhe-267 306-ThrProValArgAlaSerAla-312 319-LysGlyArgLysGlyGlyTyr-325 350-AlaGluGlyAsnValArgGlyGlyGlu-358 366-ThrGlyArgSerThrGly-371 378-AlaArgIleAsnGly-382 396-GluLeuThrGlnAlaAspLysAlaAla-404 408-GlnLysGlnLysAlaAspAlaLeu-415 298 AMPHI Regions - AMPHI 6-SerLeuPheSerSerIle-ll 13-MetSerAlaLeuIleAla-18 26-IleAsnAlaTyrTrpGlnGln-32 42-ProLeuAlaAlaTyr-46 62-LeuSerAspGlyIleLysAlaPhe-69 82-GlySerAlaAspMetProSerGlu-89 126-LeuMetGlnGlyValAla-131 134-ValGlnLysSerLeuLys-139 157-SerTyrProSerPhePheAspTrpProLysThrIleGluGluThrLeuGlnLysHisProGluIleSer-17 9 188-AsnAspProTrpAspPhe-193 208-AlaGlnGluTyrLeuLysArgValAspArgIleLeuGlu-220 245-GlnMetArgTyrLeuAspLysLeuLeuSerGluHisLeu-257 276-ArgTyrThrAspSer-280 308-AlaLysIleMetGluLys-313 Antigenic Index - Jameson-Wolf 22-SerGlnAsnProIleAsnAlaTyr-29 34-TyrHisArgAsnSerProLeuGluPro-42 47-GlyTrpTrpArgSerGlyAlaAlaLeuGlnGlu-57 70-LeuSerGlyGluThrProProThrAlaGlnAspGlyGlySerAlaAspMetProSerGluAlaAlaAla-92 94-GluAlaValProGlnThrGlyGluThrGluTrpLysGlnAspThrGluAlaAlaAlaValArgSerGlyAspL ysValPhe-120 136-LysSerLeuLysGlnGlnTyrGlyIleGluSerValAsnLeuSerLysGlnSerThrGly-155 162-PheAspTrpProLysThrIleGluGluThrLeuGlnLysHisProGlu-177 186-GlyProAsnAspProTrpAspPheProVal-195 203-AlaSerAspGluTrpAla-208 211-TyrLeuLysArgValAspArgIleLeuGlu-220 236-TyrMetLysLysAlaLysLeuAspGlyGlnMetArgTyrLeuAsp-250 252-LeuLeuSerGluHisLeuLysGly-259 270-LeuSerGlyGlyLysAspArgTyrThrAspSerValAsnValAsnGlyLysProValArgTyrArgSerLys AspGlyIle-296 318-ProSerThrGlnProSerSerThrGlnPro-327 Hydrophilic Regions - Hopp-Woods 73-GluThrProProThrAlaGlnAspGlyGlySerAlaAspMetProSerGluAlaAlaAla-92 94-GluAlaValProGlnThrGlyGluThrGluTrpLysGlnAspThrGluAlaAlaAlaValArgSerGlyAsp- 117 148-AsnLeuSerLysGlnSerThr-154 166-LysThrIleGluGluThrLeuGlnLysHisProGlu-177 211-TyrLeuLysArgValAspArglleLeuGlu-220 236-TyrMetLysLysAlaLysLeuAspGlyGlnMetArgTyrLeuAsp-250 252-LeuLeuSerGluHisLeuLysGly-259 271-SerGlyGlyLysAspArgTyrThrAsp-279 281-ValAsnValAsnGlyLysProValArgTyrArgSerLysAspGlyIle-296 319-SerThrGlnProSerSerThrGlnPro-327 299 AMPHI Regions - AMPHI 54-AlaSerProTrpMetLysLysLeuGlnSerValAlaGlnGlySer-68 71-ThrPheArgIleLeuGlnIleGly-78 85-AspPhePheThrAspSerLeuArgLysArgLeuGlnLysThrTrpGly-100 238-GlnLeuThrGlnTrpSerLysTrp-245 247-AlaAspArgMetAsnAspLeuAlaGlnThr-256 281-GluGlnLysTrpLeuAspThrValArgGlnIleArgAspSerLeu-295 307-GluSerLeuLysAsnThrLeu-313 322-ArgLeuThrGluValGlnGlnMetGlnArgArgValAlaArgGln-336 344-TrpGlnAsnAlaMetGly-349 374-GlyTyrArgArgAlaAlaGluMetLeuAlaAspSerLeuGluGluLeuValArgSerAlaAlaIleArg-39 6 Antigenic Index - Jameson-Wolf l-MetAsnProLysHis-5 35-ProSerAlaProTyrThrAspThrAsnGlyLeu-45 48-AspTyrGlyAsnAlaSerAlaSerProTrpMetLysLysLeuGln-62 65-AlaGlnGlySerGlyGluThr-71 78-GlyAspSerHisThrAlaGlyAspPhePheThrAspSerLeuArgLysArgLeuGlnLysThrTrpGlyAspG lyGly-103 llO-AlaAsnValLysGlyGlnArg-116 121-ArgHisAsnGlyAsnTrpGlnSerLeuThrSerArgAsnAsnThrGlyAspPheProLeu-140 157-AlaSerAspGlyIleAlaSerLysGlnArgVal-167 184-GlyAsnThrValSerAlaAsnGlyGlyGly-193 221-GluAsnProAlaGlyGly-226 241-GlnTrpSerLysTrpArgAlaAspArgMetAsnAspLeuAlaGlnThrGlyAla-258 266-GlyThrAsnGluAlaPheAsnAsnAsnIleAspIleAlaAspThrGluGlnLysTrp-284 286-AspThrValArgGlnIleArgAspSerLeuPro-296 305-AlaProGluSerLeuLysAsnThr-312 319-ArgProValArgLeuThrGluValGlnGlnMetGlnArgArgValAlaArgGlnGlyGlnThr-339 361-GlyTrpAlaAlaLysAspGlyVal-368 370-PheSerAlaLysGlyTyrArgArgAlaAlaGluMetLeuAlaAspSerLeuGluGluLeuValArg-391 393-AlaAlaIleArgGln-397 Hydrophilic Regions - Hopp-Woods 67-GlySerGlyGluThr-71 90-SerLeuArgLysArgLeuGlnLysThrTrpGly-100 112-ValLysGlyGlnArg-116 130-ThrSerArgAsnAsnThrGly-136 159-AspGlyIleAlaSerLysGlnArgVal-167 245-TrpArgAlaAspArgMetAsnAsp-252 276-AspIleAlaAspThrGluGlnLysTrp-284 288-ValArgGlnIleArgAspSerLeuPro-296 319-ArgProValArgLeuThrGlu-325 327-GlnGlnMetGlnArgArgValAlaArgGlnGly-337 363-AlaAlaLysAspGlyVal-368 373-LysGlyTyrArgArgAlaAlaGluMetLeuAlaAspSerLeuGluGluLeuValArg-391 393-AlaAlaIleArgGln-397 302-2 AMPHI Regions - AMPHI 20-AspGlyArgPheLeuArgThrValGluTrpLeuGlyAsnMetLeuProHisPro-37 85-LeuAsnAlaAspGlyPheIleLysIleLeuThrHisThrValLysAsnPheThrGlyPheAlaProLeuGlyT hrValLeuValSerLeu-114 127-SerAlaLeuMetArg-131 176-GlyArgHisProLeuAlaGlyLeuAlaAlaAlaPheAlaGlyValSerGly-192 201-GlyThrIleAspProLeuLeuAlaGlyIleThrGlnGlnAla-214 239-ValIleAlaLeuIleGly-244 271-ArgHisSerAsnGluIle-276 294-LeuSerAlaLeuLeuAlaTrp-300 308-IleLeuArgHisProGluThrGly-315 341-TyrGlyArgValThrArgSerLeuArgGlyGluGlnGluValValAsnAlaMetAlaGluSerMetSer-36 3 378-PheValAlaPhePheAsnTrpThrAsnIleGlyGlnTyrIle-391 448-AlaProGluValIleGlnAlaAlaTyrArgIleGlyAspSerValThrAsnIleIleThrProMetMetSer TyrPheGlyLeuIleMetAla-478 505-IleAlaTrpIleAlaLeuPheCysIle-513 Antigenic Index - Jameson-Wolf 8-LysGluLysGlnMetSerGlnThrAspThrGlnArgAspGlyArgPhe-23 61-SerValProAspProArgProValGlyAlaLysGlyArgAlaAspAspGlyLeu-78 119-IleAlaGluLysSerGly-124 134-LeuThrLysSerProArgLysLeuThr-142 152-LeuSerAsnThrAlaSerGlu-158 175-LeuGlyArgHisProLeu-180 250-LysIleValGluProGlnLeuGlyProTyrGlnSerAspLeuSerGlnGluGluLysAspIleArgHisSer AsnGluIleThrProLeuGluTyrLys-282 304-ProAlaAspGlyIleLeuArgHisProGluThrGlyLeuValSer-318 343-ArgValThrArgSerLeuArgGlyGluGlnGluVal-354 402-ValGlyLeuGlyGly-406 482-LysTyrLysLysAspAlaGlyVal-489 Hydrophilic Regions - Hopp-Woods 8-LysGluLysGlnMetSerGlnThrAspThrGlnArgAspGlyArgPhe-23 63-ProAspProArgProValGlyAlaLysGlyArgAlaAspAsp-76 119-IleAlaGluLysSerGly-124 136-LysSerProArgLysLeu-141 263-LeuSerGlnGluGluLysAspIleArgHisSerAsnGlu-275 307-GlyIleLeuArgHisProGlu-313 343-ArgValThrArgSerLeuArgGlyGluGlnGluVal-354 482-LysTyrLysLysAspAlaGly-488 305-2 AMPHI Regions - AMPHI 10-LeuMetMetGlyLeuValGluGlyPheThrGluPheLeuPro-23 33-PheGlyAsnLeuIleGly-38 66-PheSerAsnValLeuHis-71 93-AlaAlaValMetGly-97 99-LeuPheGlyLysGlnIleLysGluTyrLeuPhe-109 141-AspValAspAlaLeuArgProIleAspAla-150 155-ValAlaGlnValPheAla-160 202-AlaTyrAspValLeuLysHisTyrArgPhePheThrLeuHis-215 222-IleGlyPheIleAlaAlaPheValSer-230 235-ValLysAlaLeuLeuArg-240 Antigenic Index - Jameson-Wolf 41-SerAsnHisLysValPhe-469 61-GluTyrArgGlnArgPheSerAsn-68 72-GlyLeuGlyLysAspArgLysAlaAsn-80 128-ValGluLysArgGlnSerArgAlaGluProLysIleAlaAsp-141 143-AspAlaLeuArgProIleAsp-149 163-ProGlyThrSerArgSerGlySer-170 180-IleGluArgLysThrAlaThr-186 241-PheValSerLysLysAsnTyr-247 Hydrophilic Regions - Hopp-Woods 62-TyrArgGlnArgPhe-66 73-LeuGlyLysAspArgLysAlaAsn-80 128-ValGluLysArgGlnSerArgAlaGluProLysIleAlaAsp-141 143-AspAlaLeuArgProIleAsp-149 165-ThrSerArgSerGlySer-170 180-IleGluArgLysThrAlaThr-186 242-ValSerLysLysAsn-246 308-1 AMPHI Regions - AMPHI 6-PheTyrArgIleLeuGlyValAla-13 15-AsnLeuTyrProArgLeu-20 27-ThrIleIleAlaGlyLeu-32 64-AlaLeuGluLeuLeuArgAlaGln-71 83-AlaGluMetAlaArgAlaSerGlu-90 101-LeuAlaAspPheValHisProIleGlyAsnIleGlyAlaCys-114 131-SerMetArgThrLeuAlaSerValAlaHisGlyPheGlyAsp-144 172-LeuAlaHisLeuAspAsnMetLysArgValThrGlu-183 Antigenic Index - Jameson-Wolf 16-LeuTyrProArgLeuSerAspPheCys-24 39-TrpGluArgArgMetMetVal-45 68-LeuArgAlaGlnAspValGluThr-75 80-SerLysGlyAlaGluMetAlaArgAlaSerGluThrAlaTyrAlaArgAspGluVal-98 118-GlyThrPheLysThrAspGlyMet-125 141-GlyPheGlyAspAsnLeuLeu-147 149-ArgAlaAlaAspValValLeuLysGluArgArgArgLeu-161 166-ArgGluThrProLeu-170 176-AspAsnMetLysArgValThrGluMetGly-185 195-MetTyrArgLysProGlnThrAlaAspAspIleVal-206 219-IleAspThrProAspSerAlaGlu-226 Hydrophilic Regions - Hopp-Woods 39- rpGluArgArgMetMetVa1-45 68-LeuArgAlaGlnAspValGluThr-75 81-LysGlyAlaGluMetAlaArgAlaSerGlu-90 92-AlaTyrAlaArgAspGluVal-98 120-PheLysThrAspGly-124 149-ArgAlaAlaAspValValLeuLysGluArgArgArgLeu-161 176-AspAsnMetLysArgValThrGlu-183 195-MetTyrArgLysProGlnThrAlaAspAspIleVal-206 220-AspThrProAspSerAlaGlu-226 311-1 AMPHI Regions - AMPHI 7-SerHisTrpArgValLeuAlaGluLeuAlaAspGlyLeuProGlnHisValSerGlnLeuAlaArgMetAlaAs p-31 37-LeuAsnGlyPheTrpGlnGlnMetProAlaHisIleArgGlyLeuLeuArg-53 55-HisAspGlyTyrTrpArgLeuValArgProLeuAlaValPheAspAlaGluGlyLeuArgGluLeuGly-77 124-ArgGlnGlyArgLysTrpSerHisArgLeu-133 165-ArgAlaLeuSerArg-169 219-ValGluAsnAlaAlaSerValGlnSerLeuPheGln-230 291-PheGluGlyThrValLysGlyValAspGlyGlnGlyVal-303 362-ThrValGlySerAlaProTyrArgAspLeuSerProLeu-374 391-CysAlaValCysGlyGluPheLysLys-399 426-TyrArgHisProGluGluHisGlySerAspArgTrpPheAsnAlaLeuGlySer-443 493 -AsnLeuAsnArgHisAla-498 511-AlaValAlaSerGlyMetMetAspAlaValCys-521 550-AlaAlaLysValAlaGluAlaLeuProPro-559 576-TyrGlyLeuLeuAsnMet-581 Antigenic Index - Jameson-Wolf 28-ArgMetAlaAspMetLysProGlnGln-36 50-GlyLeuLeuArgGlnHisAspGlyTyr-58 71-GluGlyLeuArgGluLeuGlyGluArgSerGlyPhe-82 86-LeuLysHisGluCysAlaSerSerAsnAspGluIleLeuGlu-99 102-ArgIleAlaProAspLysAlaHisLys-llO 116-HisLeuGlnSerLysGlyArgGlyArgGlnGlyArgLysTrpSerHisArgLeuGlyGlu-135 145-PheAspArgProGlnTyrGluLeuGlySer-154 162-AlaCysArgArgAlaLeuSer-168 182-LeuValValGlyArgAspLysLeuGly-190 196-ThrValArgThrGlyGlyLysThrVal-204 215-LeuProLysGluValGluAsn-221 231-ThrAlaSerArgArgGlyAsnAlaAsp-239 258-TyrAlaArgAspGlyPheAla-264 272-AlaAlaAsnArgAspHisGlyLys-279 284-LeuArgAspGlyGluThrValPhe-291 293-GlyThrValLysGlyValAspGlyGlnGly-302 307-GluThrAlaGluGlyLysGlnThrValValSerGlyGluIleSerLeuArgSerAspAspArgProValSer ValProLysArgArgAspSerGluArg-339 344-AspGlyGlyAsnSerArgLeu-350 364-GlySerAlaProTyrArgAspLeuSerProLeuGly-375 378-TrpAlaGluLysAlaAspGlyAsnValArgIle-388 385-GlyGluPheLysLysAlaGlnValGln-403 405-GlnLeuAlaArgLysIleGlu-411 424-AsnHisTyrArgHisProGluGluHisGlySerAspArgTrp-437 440-AlaLeuGlySerArgArgPheSerArgAsnAla-450 464-AlaLeuThrAspAspGlyHisTyrLeuGly-473 483-MetLysGluSerLeuAla-488 492-AlaAsnLeuAsnArgHisAlaGlyLysArgTyrPro-503 529-GlyArgLeuLysGluLysThrGlyAlaGlyLysProVal-541 547-GlyGlyGlyAlaAlaLysValAlaGlu-555 565-AsnThrValArgValAlaAsp-571 584-AlaGluGlyArgGluTyrGluHis-591 Hydrophilic Regions - Hopp-Woods 28-ArgMetAlaAspMetLysProGlnGln-36 50-GlyLeuLeuArgGlnHis-55 71-GluGlyLeuArgGluLeuGlyGluArgSerGlyPhe-82 86-LeuLysHisGluCysAlaSerSerAsnAspGluIleLeuGlu-99 102-ArgIleAlaProAspLysAlaHisLys-llO 118-GlnSerLysGlyArgGlyArgGlnGlyArgLysTrpSerHisArgLeuGlyGlu-135 162-AlaCysArgArgAlaLeuSer-168 183-ValValGlyArgAspLysLeuGly-190 196-ThrValArgThrGlyGlyLys-202 217-LysGluValGluAsn-221 232-AlaSerArgArgGlyAsnAlaAsp-239 259-AlaArgAspGlyPhe-263 272-AlaAlaAsnArgAspHisGlyLys-279 285-ArgAspGlyGluThrValPhe-291 293-GlyThrValLysGlyValAspGly-300 307-GluThrAlaGluGlyLysGlnThrValVal-316 320-IleSerLeuArgSerAspAspArgProValSerValProLysArgArgAspSerGluArg-339 346-GlyAsnSerArgLeu-350 367-ProTyrArgAspLeuSer-372 378-TrpAlaGluLysAlaAspGlyAsnVal-386 395-GlyGluPheLysLysAlaGlnVal-402 405-GlnLeuAlaArgLysIleGlu-411 424-AsnHisTyrArgHisProGluGluHisGlySer-434 442-GlySerArgArgPheSerArg-448 464-AlaLeuThrAspAspGlyHis-470 483-MetLysGluSerLeuAla-488 493-AsnLeuAsnArgHisAlaGlyLysArgTyrPro-503 529-GlyArgLeuLysGluLysThrGlyAlaGlyLysProVal-541 549-GlyAlaAlaLysValAlaGlu-555 565-AsnThrValArgValAlaAsp-571 584-AlaGluGlyArgGluTyrGluHis-591 312-2 AMPHI Regions - AMPHI 6-GlyGluIleLeuGluThrValLysMetValAla-16 33-AspCysIleSerSer-37 44-GlnAsnIleTyrAsnLysIleThrThrValGlyLys-55 82-IleAlaGlnIleAlaAlaAlaThr-89 95-ValSerValAlaGlnThrLeuAspLysAlaAlaLys-106 109-GlyValSerPheIleGlyGlyPheSerAlaLeuValGln-121 133-ArgSerIleProGluAlaMetLysThr-141 167-GlyGluThrValLysArgThrAla-174 182-GlyCysAlaLysIleValValPheCys-190 230-SerAspAlaThrThrLeuThrGluValAlaGluValValLysLys-244 249-1leThrArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 281-ValGlyAspSerValAlaArgIleLeuGluGluMetGly-293 309-LeuAsnAspAlaVal-313- 322-SerAlaValGlyGlyLeuSerGly-329 349-LeuThrLeuAspLysLeuGluAlaMetThrAla-359 374-ThrProAlaHisThrIleSerGlyIleIle-383 409-ValGlyAspSerValGluPheGlyGlyLeuLeuGly-420 Antigenic Index - Jameson-Wolf 4-GlnSerGlyGluIleLeuGlu-10 13-LysMetValAlaAspGlnAsnPheAspVal-22 35-IleSerSerAspIle-39 52-ThrValGlyLysAspLeuValThr-59 89-ThrHisAlaAspSer-93 100-ThrLeuAspLysAlaAlaLys-106 121-GlnLysGlyMetSerProSerAspGluValLeu-131 134-SerIleProGluAlaMetLysThrThrAsp-143 152-GlySerThrArgAla-156 161-AspAlaValLysLeuAlaGlyGluThrValLysArgThrAlaGluIleThrProGluGlyPheGly-182 192-AlaValGluAspAsnProPhe-198 204-HisGlySerGlyGluAlaAspAla-211 225-AlaAlaLeuGluAsnSerAspAla-232 237-GluValAlaGluValValLys-243 251-ArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 280-AlaValGlyAspSerValAlaArgIleLeuGlu-290 311-AspAlaValLysLysGlyGlyMet-318 334-ValSerGluAspGluGlyMet-340 352-AspLysLeuGluAla-356 370-ValProGlyAspThrProAla-376 383-IleAlaAspGluAlaAla-388 392-IleAsnSerLysThrThrAla-398 405-ThrGlyLysThrValGlyAspSerValGlu-414 426-ProValLysGluGlySerCys-432 435-PheValAsnArgGlyGlyArgIle-442 447-GlnSerMetLysAsn-451 Hydrophilic Regions - Hopp-Woods 18-GlnAsnPheAspVal-22 52-ThrValGlyLysAspLeuValThr-59 100-ThrLeuAspLysAlaAlaLys-106 123-GlyMetSerProSerAspGluValLeu-131 134-SerIleProGluAlaMetLysThrThrAsp-143 16l-AspAlaValLysLeuAlaGlyGluThrValLysArgThrAlaGluIleThrPro-178 192-AlaValGluAspAsnPro-197 207-GlyGluAlaAspAla-211 225-AlaAlaLeuGluAsnSerAspAla-232 237-GluValAlaGluValValLys-243 251-ArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 284-SerValAlaArgIleLeuGlu-290 311-AspAlaValLysLysGlyGlyMet-318 334-ValSerGluAspGluGlyMet-340 352-AspLysLeuGluAla-356 383-IleAlaAspGluAlaAla-388 408-ThrValGlyAspSerValGlu-414 426-ProValLysGluGlySerCys-432 438-ArgGlyGlyArgIle-442 447-GlnSerMetLysAsn-451 313-2 AMPHI Regions - AMPHI 27-GlyMetAspAspProArgThrTyrGlySerGly-37 41-AlaThrAsnValLeu-45 60-AspAlaAlaLysGly-64 66-ValAlaValLeuLeuAlaArgValLeuGlnGluPro-77 88-ValAlaLeuAlaAlaLeuValGlyHisMetTrpPro-99 143-SerLeuAlaAlaLeuThrAlaThrIleAlaAlaProVal-155 Antigenic Index - Jameson-Wolf 26-TyrGlyMetAspAspProArgThrTyrGlySerGlyAsnProGlyAla-41 46-ArgSerGlyLysLysLysAlaAla-53 73-ValLeuGlnGluProLeuGlyLeuSerAspSerAla-84 104-PheLysGlyGlyLysGlyVal-110 181-HisLysSerAsnIle-185 189-LeuGluGlyArgGluSerLysIleGlyGlySerArg-200 Hydrophilic Regions - Hopp-Woods 26-TyrGlyMetAspAspProArgThrTyrGly-35 46-ArgSerGlyLysLysLysAlaAla-53 105-LysGlyGlyLysGlyVal-110 181-HisLysSerAsnIle-185 189-LeuGluGlyArgGluSerLysIleGlyGlySerArg-200 401 AMPHI Regions - AMPHI 46-ValLysProTyrAsnAlaLeu-52 65-CysTyrAsnCysHisSerGlnMetIleArgProPheArg-77 112-ValGlyGlyArgTyrSerAspGluTrpHisArgIle-123 157-MetLysAlaLeuArgLysValGlyThr-165 172-IleAlaLysAlaProGluAlaLeu-179 Antigenic Index - Jameson-Wolf 5-GlnLeuAlaGluGluLysIle-ll 38-AlaAlaThrGlnProAlaProGlyValLysProTyrAsn-50 55-AlaGlyArgAspIleTyrIleArgGluGlyCysTyrAsnCysHis-69 74-ArgProPheArgAlaGluThrGluArgTyrGlyHis-85 90-GlyGluSerValTyr-94 98-PheGlnTrpGlySerLysArgThrGlyProAspLeuAlaArgValGlyGlyArgTyrSerAspGluTrpHis- 121 125-LeuLeuAsnProArgAspValValProGluSerAsnMetPro-138 146-AsnLysValAspValAspAla-152 158-LysAlaLeuArgLysValGlyThrProTyrSerAspGluGluIleAlaLysAlaProGlu-177 179-LeuAlaAsnLysSerGluLeuAspAla-187 Hydrophilic Regions - Hopp-Woods 5-GlnLeuAlaGluGluLysIle-ll 76-PheArgAlaGluThrGluArgTyrGly-84 101-GlySerLysArgThrGlyProAspLeuAlaArgValGlyGlyArgTyrSerAspGluTrpHis-121 127-AsnProArgAspValValPro-133 146-AsnLysValAspValAspAla-152 158-LysAlaLeuArgLysValGly-164 167-TyrSerAspGluGluIleAlaLysAlaProGlu-177 179-LeuAlaAsnLysSerGluLeuAspAla-187 402-2 AMPHI Regions - AMPHI 18-PheLeuSerGlyLeu-22 85-AlaGlyIleAlaAspPhe-90 100-ThrGlyPheSerGlyPheValHis-107 117-AlaValValArgGlyLeu-122 136-LysSerGlyArgGln-140 146-PheAlaAsnValAlaGly-151 218-ValPheGlnAsnIleAlaAspArgProAspArgLeuIle-230 261-AspValPheAsnSerValAsnGlyIleGlu-270 279-LysSerGlyIleArg-283 294-SerTrpAlaArgValLeuSerAlaIleProGluMetGln-306 344-ArgLysTrpLeuArgArgHisPro-351 376-AlaGluPheLeuLysGlnValGlnSerHisLeu-386 398-HisSerProHisAlaPheAlaThrAlaValHisSerIlePro-411 437-GlnArgLeuSerArgLeu-442 460-AlaAlaGlnLysVal-464 Antigenic Index - Jameson-Wolf 4-ValAsnThrLysProAsnThrSer-ll 66-ArgIleCysArgSerArgPheValAsp-74 130-ValGlyThrAspGlyAsnLysSerGlyArgGlnValSer-142 222-IleAlaAspArgProAspArgLeuIleGluAsnLysHisGly-235 240-TyrHisArgAspGlyAspLysValVal-248 264-AsnSerValAsnGlyIleGluArg-271 277-SerLeuLysSerGlyIleArgArg-284 321-IleAlaAspGluProGln-326 331-LeuGlnAspLysArgValGluIleValLeuAspAspGlyArgLysTrpLeuArgArgHisProAspGluLys PheAsp-356 385-HisLeuThrProAspGly-390 429-PheProAsnLysGluLeuLeuLysGlnArgLeuSer-440 444-TrpProGluSerGlyArgHisValPheAspSerSerThrVal-457 472-MetThrGluProSerAlaGly-478 481-ValIleThrAspAspAsnMet-487 489-ValGluTyrLysTyrGlyArgGlyIle-497 Hydrophilic Regions - Hopp-Woods 131-GlyThrAspGlyAsnLysSerGlyArgGlnVal-141 222-IleAlaAspArgProAspArgLeuIleGluAsnLysHis-234 241-HisArgAspGlyAspLysValVal-248 278-LeuLysSerGlyIleArg-283 321-IleAlaAspGluProGln-326 331-LeuGlnAspLysArgValGluIleValLeuAspAspGlyArgLysTrpLeuArgArgHisProAspGluLys PheAsp-356 430-ProAsnLysGluLeuLeuLysGlnArgLeuSer-440 446-GluSerGlyArgHisValPhe-452 473-ThrGluProSerAlaGly-478 481-ValIleThrAspAspAsnMet-487 501-2 AMPHI Regions - AMPHI 63-ValGluValLeuGlnGluLeuPheArgGlnTyrArgValAlaArgGlnLeu-79 88-ValPheAlaAlaPheGlnAlaVal-95 97-PheGlnGlyPheAspAsnGlyPhe-104 126-AlaAspAlaPheGlnGly-131 139-ValPheGluValValGlyAspIleThrArgArgThrThrGluAla-153 183-AspGlyPheThrArgl1eAsnArgCysGlyGlnCys-194 196-HisAlaPheGlyAspPheIleAsp-203 Antigenic Index - Jameson-Wolf 6-LeuThrAlaAspAla-10 17-AlaAlaGlyGlyAspGlyLysValGlnHisHisPheAspGlyArgValAlaPhe-34 46-ValGluThrGluGlyGln-51 56-ValArgAlaAspGlyGluAlaValGluVal-65 100-PheAspAsnGlyPhe-104 108-GlnSerAlaAspGluArgAsnHisAspPheAsnValGlyGln-121 144-GlyAspIleThrArgArgThrThrGluAlaGlnHis-155 179-GlyHisThrAspAspGlyPheThrArgIleAsnArgCysGlyGlnCysArgHisAlaPhe-198 202-IleAspValGluValAspArgGlyArgValThrGlyAspThrAlaGlyAsnPhe-219 Hydrophilic Regions - Hopp-Woods 6-LeuThrAlaAspAla-10 19-GlyGlyAspGlyLysVal-24 46-ValGluThrGluGlyGln-51 56-ValArgAlaAspGlyGluAlaValGluVal-65 108-GlnSerAlaAspGluArgAsnHisAsp-116 144-GlyAspIleThrArgArgThrThrGluAlaGlnHis-155 179-GlyHisThrAspAspGlyPheThrArglleAsnArg-190 202-IleAspValGluValAspArgGlyArgValThrGlyAspThr-215 502-1 AMPHI Regions - AMPHI 6-AsnLeuPheGlnPheLeuAlaValCys-14 26-GlyAlaValAspAlaLeuLysGlnPheAsnAsnAspAlaAspGlyIleSerGlySerPheThrGln-47 98-GlnValThrLysSerSerGlnAsp-105 Antigenic Index - Jameson-Wolf 32-LysGlnPheAsnAsnAspAlaAspGlyIleSerGlySer-44 48-ThrValGlnSerLysLysLysThrGlnThrAlaHisGlyThr-61 73-GluTyrThrLysProTyrArg-79 98-GlnValThrLysSerSerGlnAspGlnAlaIleGlyGlySerPro-112 116-LeuSerAsnLysThrAlaLeuGluSerSerTyrThrLeuLyεGluAspGlySerSerAsnGly-136 142-AlaThrProLysArgAsnAsnAlaGly-150 158-PheLysGlyGlyAsn-162 167-GlnLeuLysAspSerPheGlyAsnGlnThr-176 184-AsnThrAsnProGlnLeuSerArgGlyAlaPhe-194 196-PheThrProProLysGlyValAspVal-204 Hydrophilic Regions - Hopp-Woods 34-PheAsnAsnAspAlaAspGly11e-41 49-ValGlnSerLysLysLysThrGlnThr-57 ThrLysSerSerGlnAspGlnAlaIle-108 126-TyrThrLeuLysGluAspGlySerSerAsn-135 143-ThrProLysArgAsnAsnAla-149 167-GlnLeuLysAspSerPheGly-173 503-1 AMPHI Regions - AMPHI 96-SerSerThrSerAsnPheAlaSerAlaAlaGluMetArgSerLeu-110 Antigenic Index - Jameson-Wolf 4-SerLeuTyrArgGluAlaAsnThrTrpCys-13 32-ProAlaAsnAspAlaΞerGlyArgSerSerAlaValAlaGluGluArgThrAlaThrGluMetSerAlaProP roAla-57 69-SerAlaSerSerCysSerGlyLysGlyValSer-79 87-LeuProThrArgAlaSerSerAlaThrSerSerThrSerAsn-100 105-AlaGluMetArgSerLeuArg-lll 113-LeuCysAlaArgAsnAlaArg-119 Hydrophilic Regions - Hopp-Woods 4-SerLeuTyrArgGlu-8 32-ProAlaAsnAspAlaSerGlyArgSerSerAlaValAlaGluGluArgThrAlaThrGluMetSerAla-54 73-CysSerGlyLysGlyValSer-79 89-ThrArgAlaSerSer-93 105-AlaGluMetArgSerLeuArg-lll 505-2 AMPHI Regions - AMPHI 20-LeuThrAlaLeuLeuLysCysLeuSerLeuLeuProLeuSerCysLeu-35 37-ThrLeuGlyAsnArg-41 89-ProAlaPhePheArgLysProGluAspIleGluThrMetPheLysAlaValHisGlyTrpGluHisValGlnG lnAlaLeuAsp-116 148-AlaMetTyrLysProProLysIleLysAlaIleAspLysIleMetGlnAlaGly-165 178-IleGlnGlyValLysGlnIleIleLysAlaLeuArg-189 210-GlyValTrpValAspPhePheGlyLysPro-219 Antigenic Index - Jameson-Wolf 39-GlyAsnArgLeuGly-43 50-LeuLysGluAspArgAlaArgIle-57 64-AlaGlyLeuAsnProAspProLysThrValLys-74 79-GluThrAlaLysGlyGlyLeu-85 92-PheArgLysProGluAspIleGluThr-100 114-AlaLeuAspLysHisGlu-119 131-TyrAspLeuGlyGlyArgTyrIleSer-139 150-TyrLysProProLysIleLysAlaIleAspLysIleMetGln-163 165-GlyArgValArgGlyLysGlyLysThrAlaProThrSer-177 183-GlnIleIleLysAlaLeuArgSerGlyGluAlaThr-194 199-AspHisValProSerProGlnGluGlyGlyGluGlyVal-211 243-GluArgLeuProGlyGlyGlnGly-250 258-ValGlnGlyGluLeuAsnGlyAspLysAlaHisAsp-269 293-AsnArgTyrLysMetPro-298 Hydrophilic Regions - Hopp-Woods 50-LeuLysGluAspArgAlaArgIle-57 65-GlyLeuAsnProAspProLysThrVal-73 79-GluThrAlaLysGlyGlyLeu-85 92-PheArgLysProGluAspIleGluThr-100 114-AlaLeuAspLysHisGlu-119 151-LysProProLysIleLysAlaIleAspLysIleMetGln-163 165-GlyArgValArgGlyLysGlyLysThrAlaPro-175 183-GlnIleIleLysAlaLeuArgSerGlyGlu-192 201-ValProSerProGlnGluGlyGlyGlu-209 258-ValGlnGlyGluLeuAsnGlyAspLysAlaHisAsp-269 506-2 AMPHI Regions - AMPHI 6-GluValGlyArgValAlaHisCysGlyGlyGlyVal-17 25-ArgValValHisGlnValGluGlnGlyAlaArg-35 56-PheGlnArgArgPhe-60 99-AlaThrArgThrIleAspGlyAsnLeuAlaGluValTyrAlaGlnThr-114 138-GlyAsnGluValAlaArgCys-144 180-GlnValLysArgMetIleArgTyrPhePheArgVal-191 Antigenic Index - Jameson-Wolf 13-CysGlyGlyGlyValAla-18 31-GluGlnGlyAlaArgLeu-36 54-ValAspPheGlnArgArgPheGlyGluVal-63 98-ArgAlaThrArgThr11eAspGlyAsnLeu-107 134-GlyAlaAspThrGlyAsnGluValAlaArgCysGluGly-146 176-ProAsnPheGlyGlnValLysArgMetIle-185 195-HisAspLeuAspVal-199 201-ArgProPheArgLys-205 Hydrophilic Regions - Hopp-Woods 31-GluGlnGlyAlaArgLeu-36 54-ValAspPheGlnArgArgPheGlyGlu-62 98-ArgAlaThrArgThrIleAsp-104 136-AspThrGlyAsnGluValAlaArgCysGluGly-146 180-GlnValLysArgMetIle-185 195-HisAspLeuAspVal-199 201-ArgProPheArgLys-205 513 AMPHI Regions - AMPHI 6-AsnAlaAlaAlaAlaAla-ll 19-GlnGlyMetIleGlnMetLeuGlyValPheValAsp-30 48-ProTyrGlyAspLeu-52 63-ValSerGlnValGlyGlnTrp-69 107-ThrAlaVa1PheArgMet-112 119-TyrPheGlyAlaValAla-124 139-IleMetAlaTrpIleAsnLeuValAlaIleLeuLeuLeuSer-152 Antigenic Index - Jameson-Wolf 2-GlySerAlaProAsnAla-7 ll-AlaGluValLysHisProVal-17 47-GlnProTyrGlyAspLeuSerGly-54 91-AlaTyrAlaGluSerAsnVal-97 160-ArgAspTyrThrAlaLysLeuLysMetGlyLysAspProGluPheLysLeuSerGluHisProGlyLeuLys ArgArgIleLysSerAspValTrp-191 Hydrophilic Regions - Hopp-Woods H-AlaGluValLysHis-15 166-LeuLysMetGlyLysAspProGluPheLysLeuSerGlu-178 180-ProGlyLeuLysArgArgIleLysSer-188 515-1 AMPHI Regions - AMPHI 8-ArgAlaAlaGlyValAlaArgGlyLeuHisThrGluPheAlaArgAlaVal-24 59-AspValArgPhePheAlaGlnValGluGluIleGlyGlnAspPhePheAlaAspAla-77 90-AlaGlyGluCysAlaAspGluValSerAspLysThr-101 122-GluSerAlaGlnSerAlaAlaGlyGlyGlyLeuThrAspGlyPheGly-137 176-CysGlyLysThrValGlyVal-182 198-GlyValPheAspAla-202 251-PheGlyGlyValAla-255 259-AspGlyGlyPheAspGlyValLeuGlnGlyPhePheGlyGluVal-273 Antigenic Index - Jameson-Wolf 24-ValThrAlaGluGluIleAlaPhe-31 38-HisGluAlaArgCysGlyGlyAsn-45 51-IleAlaAlaAlaGluArgAlaGlyAsp-59 67-GluGluIleGlyGln-71 77-AlaValAspGlnGluThr-82 84-LeuAlaValGluArgAlaAlaGlyGluCysAlaAspGluValSerAspLysThrAlaArgAsnGlyGlyIleG luGluAspGlyValAlaAlaCysArgAspAlaAlaAlaAlaGluSerAlaGln-125 128-AlaGlyGlyGlyLeuThrAspGly-135 160-GlyGlyAsnAspAlaAlaGlyAsn-167 192-LeuHisArgArgAla-196 217-AlaAspGlyGlyPheArg-222 239-HisGlnThrGlyIleGlyLysSerGly-247 256-GlyAspValAspGlyGlyPheAspGly-264 273-ValGlySerThrGlyAla-278 284-AspValAsnGlyAsnValGln-290 Hydrophilic Regions - Hopp-Woods 24-ValThrAlaGluGluIleAlaPhe-31 38-HisGluAlaArgCysGly-43 51-IleAlaAlaAlaGluArgAlaGlyAsp-59 77-AlaValAspGlnGluThr-82 84-LeuAlaValGluArgAlaAlaGlyGluCysAlaAspGluValSerAspLysThrAlaArgAsnGlyGlyIleG luGluAspGlyValAlaAlaCysArgAspAlaAlaAlaAlaGluSerAlaGln-125 162-AsnAspAlaAlaGly-166 192-LeuHisArgArgAla-196 242-GlyIleGlyLysSerGly-247 256-GlyAspValAspGlyGlyPhe-262 519-1 AMPHI Regions - AMPHI 15-GlyPheLysSerPhe-19 29-ValValGluArgLeuGlyArgPheHisArgAlaLeuThrAlaGly-43 105-MetAlaIleThrGlnLeuAlaGlnThrThrLeuArgSerVal-118 141-AlaLeuAspGluAlaAla-146 166-GluIleLeuArgSerMetGlnAla-173 192-LysIleGluGlnIle-196 221-SerAsnAlaGluLysIleAlaArgIleAsn-230 249-AlaIleArgGlnIleAlaAlaAla-256 273-GlnTyrValAlaAlaPheAsnAsnLeuAlaLys-283 292-AlaAsnValAlaAspIleGlySerLeuIleSerAlaGlyMetLysIleIleAspSerSerLysThrAla-31 4 Antigenic Index - Jameson-Wolf 3 l-GluArgLeuGlyArgPheHisArg-38 58-HisSerLeuLysGluIleProLeuAspValProSerGln-70 72-Cys11eThrArgAspAsnThrGlnLeuThrVa1-82 91-ThrAspProLysLeuAlaSer-97 122-MetGluLeuAspLysThrPheGluGluArgAspGluIleAsn-135 141-AlaLeuAspGluAlaAlaGly-147 154-LeuArgTyrGluIleLysAspLeuValPro-163 175-IleThrAlaGluArgGluLysArgAlaArgIleAlaGluSerGluGlyArgLysIleGluGln-195 197-AsnLeuAlaSerGlyGlnArgGluAlaGluIleGlnGlnSerGluGlyGluAlaGlnAla-216 219-AsnAlaSerAsnAlaGluLysIleAlaArgIleAsnArgAlaLysGlyGluAlaGluSerLeuArgLeu-24 1 245-AlaAsnAlaGluAlaIleArg-251 258-GlnThrGlnGlyGlyAlaAspAlaValAsn-267 281-LeuAlaLysGluSerAsnThr-287 303-AlaGlyMetLysIleIleAspSerSerLysThrAlaLys-315 Hydrophilic Regions - Hopp-Woods 31-GluArgLeuGlyArgPheHisArg-38 58-HisSerLeuLysGluIleProLeu-65 73-IleThrArgAspAsnThr-78 91-ThrAspProLysLeu-95 122-MetGluLeuAspLysThrPheGluGluArgAspGluIleAsn-135 141-AlaLeuAspGluAlaAla-146 154-LeuArgTyrGluIleLysAspLeuValPro-163 175-IleThrAlaGluArgGluLysArgAlaArgIleAlaGluSerGluGlyArgLysIleGluGln-195 200-SerGlyGlnArgGluAlaGluIleGlnGlnSerGluGlyGluAlaGlnAla-216 221-SerAsnAlaGluLysIleAlaArgIleAsnArgAlaLysGlyGluAlaGluSerLeuArgLeu-241 245-AlaAsnAlaGluAlaIleArg-251 281-LeuAlaLysGluSerAsn-286 306-LysIleIleAspSerSerLysThrAlaLys-315 520-1 AMPHI Regions - AMPHI 104-LeuThrLysAlaAlaAspGlyGlnValCysArgAlaPheSerSerLeu-119 Antigenic Index - Jameson-Wolf 20-LysProSerArgArgAlaLeu-26 47-AlaSerGlyLysIleSerLeuPro-54 84-ProProAsnAsnSerThrThrThrSerThrSerSerArgAlaThrSerSerAsnGlySerLeuThrLysAlaA laAspGlyGlnVal-112 117-SerSerLeuLysSerHisThrAlaGluIleArgIleSerArgProLysArgArgGluIleSerSerAlaLeu SerArgAsnThrAlaAla-146 150-ProThrValProLysProLysArgProMet-159 166-SerProCysLysProThrGluMet-173 Hydrophilic Regions - Hopp-Woods 20-LysProSerArgArgAlaLeu-26 93-ThrSerSerArgAlaThrSerSer-100 103-SerLeuThrLysAlaAlaAsp-109 120-LysSerHisThrAlaGluIleArgIleSerArgProLysArgArgGluIleSer-137 140-LeuSerArgAsnThrAla-145 151-ThrValProLysProLysArgProMet-159 168-CysLysProThrGluMet-173 521-2 AMPHI Regions - AMPHI 39-ThrLysProSerLysSerCys-45 50-LeuProProIleGly-54 65-GlnThrProGluProValSerSerProSer-74 76-GlyGlyGlnValVal-80 86-ValLysThrValSerLysProAlaLys-94 133-GlnAlaArgLeuAlaLysGlyGlyAsn-141 Antigenic Index - Jameson-Wolf 36-ValTyrThrThrLysProSerLysSerCysHisSerThrAspLeuProProIleGlyAsnTyrSerSerGluA rgTyrlleProProGlnThrProGluProValSerSerProSerAsnGlyGlyGlnValValLysTyrLysAlaPr oValLysThrValSerLysProAlaLysSerAsnThrProProProGlnGlnAlaProSerAsnAsnSerArgArg SerIleLeuGluThrGluLeuSerAsnGluArgLysAlaLeuValGluAlaGlnLysMetLeuSer-132 135-ArgLeuAlaLysGlyGlyAsnIleAsn-143 152-SerAsnValLeuAspArgGlnGlnAsn-160 164-LeuGlnArgGluLeuGlyArg-170 Hydrophilic Regions - Hopp-Woods 40-LysProSerLysSerCysHis-46 57-SerSerGluArgTyrIle-62 65-GlnThrProGluProValSer-71 80-ValLysTyrLysAlaProVal-86 88-ThrValSerLysProAlaLysSerAsnThrProPro-99 102-GlnAlaProSerAsnAsnSerArgArgSerIleLeuGluThrGluLeuSerAsnGluArgLysAlaLeuVal GluAlaGlnLysMetLeuSer-132 154-ValLeuAspArgGlnGlnAsn-160 164-LeuGlnArgGluLeuGlyArg-170 522 AMPHI Regions - AMPHI 32-TrpValIleLeuAlaLeuLeuAlaLeuThrAlaLeuLeuΞer-45 57-LysIleValGluSerCysValLys-64 96-MetTrpGluGlnProLeuAspArgLeuSerGluLysGlnIleArgSerPheGlyLysLeuGlyAlaGlnGluG lnLeuAspLeuLeuGlyGlyAla-127 Antigenic Index - Jameson-Wolf 1-MetThrGluProLysHisGluMetLeuThrLysGluGlnValAlaAlaArgLysLysAlaLysAlaLysIleAr gThr-26 48-AlaMetSerLysProGlnAlaLysGlnLysIleValGluSerCysValLys-64 71-LysTrpGlnAsnAspLeuArgAlaArgGlyLeuAspSerAsnAsnThrArgLeuAla-89 99-GlnProLeuAspArgLeuSerGluLysGlnIleArgSerPheGlyLysLeuGlyAla-117 128-AsnAlaPheGluAlaArgAspLysGlnCysValAlaAspLeuLysSerGlu-144 Hydrophilic Regions - Hopp-Woods 1-MetThrGluProLysHisGluMetLeuThrLysGluGlnValAlaAlaArgLysLysAlaLysAlaLysIleAr gThr-26 48-AlaMetSerLysProGlnAlaLysGlnLysIleValGluSerCysVal-63 71-LysTrpGlnAsnAspLeuArgAlaArgGlyLeuAspSerAsnAsnThr-86 100-ProLeuAspArgLeuSerGluLysGlnlleArgSerPheGly-113 130-PheGluAlaArgAspLysGlnCysValAlaAspLeuLysSerGlu-144 525-1 AMPHI Regions - AMPHI 59-GluPheAlaGluPheValAsnSerHisProGln-69 86-LysHisTrpMetLysAsnGly-92 125-ArgLeuProThrIleAspGluTrpGluPhe-134 154-ThrIleLeuAspTrpTyr-159 164-ArgLysGlyLeuHisAspValGly-171 178-TrpGlyValTyrAsp-182 188-TrpGluTrpThrGlu-192 Antigenic Index - Jameson-Wolf 24-ValGlnIleGluGlyGlySerTyrArgProLeuTyrLeuLysLysAspThrGlyLeuIleLys-44 46-LysProPheLysLeuAspLysTyrProValThr-56 67-HisProGlnTrpGlnLysGlyArgIleGlySerLysGlnAlaGlu-81 88-TrpMetLysAsnGlySerArgSerTyrAlaProLysAlaGlyGluLeuLysGlnPro-106 122-GlnGlyLysArgLeuProThrIleAspGluTrpGlu-133 140-AlaThrGlnLysAsnGlySerAsnGluProGlyTyrAsnArgThr-154 159-TyrAlaAspGlyGlyArgLysGlyLeuHisAspValGlyLysGlyArgProAsnTyr-177 190-TrpThrGluAspPheAsnSerSerLeuLeuSerSerGlyAsnAla-204 213-AlaSerIleGlySerSerAspSerSerAsnTyr-223 234-SerLeuGlnSerLysTyr-239 Hydrophilic Regions - Hopp-Woods 35-TyrLeuLysLysAspThrGlyLeuIleLys-44 46-LysProPheLysLeuAspLysTyrPro-54 71-GlnLysGlyArgIleGlySerLysGlnAlaGlu-81 91-AsnGlySerArgSerTyrAlaProLysAlaGlyGluLeuLysGln-105 122-GlnGlyLysArgLeuProThr-128 140-AlaThrGlnLysAsnGlySerAsnGluProGlyTyr-151 162-GlyGlyArgLysGlyLeuHisAspValGlyLysGlyArgPro-175 216-GlySerSerAspSerSerAsn-222 527-2 AMPHI Regions - AMPHI 7-PhePheGlnProValGln-12 28-SerAspAlaAlaGluLeuValGluLeuPheAlaLeuPhePro-41 73-GlyLysGlyIleGluArgGlnValAspAsnIleAlaAspValTyrGlyPhe-89 Antigenic Index - Jameson-Wolf 26-GlyGlySerAspAlaAlaGlu-32 52-GlnLysProArgLeuGlyCys-58 71-PheIleGlyLysGlyIleGluArgGlnValAspAsnIleAla-84 107-LeuLeuArgLysGlyThrGlyLeuGluLysThrCysArgProLysProPheValGlnProHisGlyGlyArg -130 Hydrophilic Regions - Hopp-Woods 27-GlySerAspAlaAlaGlu-32 52-GlnLysProArgLeuGlyCys-58 75-GlyIleGluArgGlnValAspAsnIleAla-84 107-LeuLeuArgLysGlyThrGlyLeuGluLysThrCysArgProLysPro-122 528-1 AMPHI Regions - AMPHI 7-LysTyrThrAlaMetAlaAlaLeuLeuAlaPhe-17 23-ArgLeuAlaGlyTrpTyrGluCysSerSerLeuThrGlyTrpCysLysProArgLysProAlaAlaIle-45 69-AsnArgSerValArg-73 86-TyrArgLysIleGlyLysPhe-92 106-ProLeuIleGluThrPheLys-112 Antigenic Index - Jameson-Wolf l-MetGluIleArgAla-5 29-GluCysSerSerLeuThrGlyTrpCysLysProArgLysProAlaAla-44 49-AspIleGlyGlyGluSerProProSerLeuGlyAspTyrGluIleProLeuSerAspGlyAsnArgSerValA rgAlaAsnGluTyrGluSerAlaGlnGlnSer-83 88-LysIleGlyLysPheGluAlaCysGlyLeuAspTrpArgThrArgAspGlyLysProLeu-107 110-ThrPheLysGlnGlyGlyPheAspCysLeuGluLysGlnGlyLeuArgArgAsnGlyLeuSerGluArgVal ArgTrp-135 Hydrophilic Regions - Hopp-Woods l-MetGluIleArgAla-5 37-CysLysProArgLysProAlaAla-44 51-GlyGlyGluSerProProSer-57 59-GlyAspTyrGluIleProLeu-65 67-AspGlyAsnArgSerValArgAlaAsnGluTyrGluSerAlaGln-81 88-LysIleGlyLysPheGluAlaCys-95 99-TrpArgThrArgAspGlyLysProLeu-107 117-AspCysLeuGluLysGlnGlyLeuArgArgAsnGlyLeuSerGluArgValArgTrp-135 529 AMPHI Regions - AMPHI ll-LeuAlaLeuIleGlyLeuAlaAlaCysSer-20 35-SerHisArgLeuIle-39 49-AsnProAspGlnGlyAsnLeuTyrArgLeuProAla-60 79-GlnGlnProAlaAspAlaGluValLeuLysSerValLysGlyValArg-94 152-GlnAspSerLeuArgArgLeuPheAsp-160 196-AlaMetLysGluVal-200 223-AlaPheLeuThrArgPheMetGlnTyrLeu-232 252-AlaAsnGluMetAla-256 270-GlyArgAsnTrpArgArgThrVa1-277 Antigenic Index - Jameson-Wolf 19-CysSerGlySerLysThrGluGlnProLysLeuAspTyrGlnSerArgSerHisArgLeuIleLys-40 42-GluValProProAspLeuAsnAsnProAspGlnGlyAsnLeuTyr-56 60-AlaGlySerGlyAlaValArgAlaSerAspLeuGluLysArgArgThrProAlaVal-78 80-GlnProAlaAspAlaGluValLeuLysSerValLysGlyValArgLeuGluArgAspGlySerGln-101 105-ValValAspGlyLysSerProAlaGlu-113 123-GlnGluAsnGlyPheAspIleLysSerGluGluProAla-135 139-MetGluThrGluTrpAlaGluAsnArgAlaLysIleProGlnAspSerLeuArgArgLeuPheAsp-160 169-SerThrGlyGluArgAspLysPheIleValArgIleGluGlnGlyLysAsnGlyValSer-188 195-LysAlaMetLysGluValTyrGlyGlyLysAspLysAspThrThr-209 212-GlnProSerProSerAspProAsnLeu-220 233-GlyValAspGlyGlnGlnAlaGluAsnAlaSerAlaLysLysProThrLeu-249 253-AsnGluMetAlaArgIleGluGlyLysSer-262 268-AspTyrGlyArgAsnTrpArgArgThrVal-277 289-GlyGlnAsnThrGluArgHisAla-296 300-GlnLysAlaProAsnGluSerAsnAlaValThrGluGlnLysProGlyLeu-316 32O-LeuLeuGlyLysGlyLysAlaGluLysProAlaGluGlnProGlu-334 342-ValAlaAsnGlySerArg-347 350-LeuLeuAsnLysAspGlySerAlaTyrAlaGlyLysAspAlaSer-364 370-LeuHisSerGluLeuArg-375 Hydrophilic Regions - Hopp-Woods 20-SerGlySerLysThrGluGlnProLysLeuAspTyrGlnSerArgSerHisArgLeuIleLys-40 42-GluValProProAspLeuAsnAsnProAspGln-52 63-GlyAlaValArgAlaSerAspLeuGluLysArgArgThrProAla-77 80-GlnProAlaAspAlaGluValLeuLysSerValLysGlyValArgLeuGluArgAspGlySerGln-101 107-AspGlyLysSerProAla-112 125-AsnGlyPheAspIleLysSerGluGluProAla-135 139-MetGluThrGluTrpAlaGluAsnArgAlaLysIleProGlnAspSerLeuArgArgLeuPheAsp-160 170-ThrGlyGluArgAspLysPheIleVal-178 180-IleGluGlnGlyLysAsnGlyVal-187 195-LysAlaMetLysGluValTyrGlyGlyLysAspLysAspThrThr-209 214-SerProSerAspProAsnLeu-220 235-AspGlyGlnGlnAlaGluAsnAlaSerAlaLysLysProThr-248 253-AsnGluMetAlaArgIleGluGlyLysSer-262 269-TyrGlyArgAsnTrpArg-274 291-AsnThrGluArgHis-295 302-AlaProAsnGluSerAsnAlaValThrGluGlnLysProGlyLeu-316 320-LeuLeuGlyLysGlyLysAlaGluLysProAlaGluGlnProGlu-334 352-AsnLysAspGlySer-356 359-AlaGlyLysAspAlaSer-364 370-LeuHisSerGluLeuArg-375 531 AMPHI Regions - AMPHI 59-SerLeuAlaGlyIleLeuAlaAspTyrValAlaGlyIleTrpGlyThr-74 90-GlySerIleIleGlyIlePhePheSerLeuProGlyLeuIleLeuGly-105 108-IleGlyAlaAlaAlaGly-113 132-LeuLeuGlyLeuValVal-137 Antigenic Index - Jameson-Wolf 74-ThrLysTyrThrGlyAlaGlyLysLeuAlaVal-84 114-GluLeuIleGluArgArgAsnMet-121 Hydrophilic Regions - Hopp-Woods 114-GluLeuIleGluArgArgAsnMet-121 532 AMPHI Regions - AMPHI 6-GlyLysGlyAlaAsp-10 27-AlaLeuLeuSerAlaValThrHisLeuLeuAlaIlePheValProMetIleThr-44 76-TyrLeuGlnValAsnArgPheGlyPro-84 122-SerThrLeuLeuGly-126 147-LysValIleThrProThrVal-153 184-ThrPheGlySerMetGluAsnLeuGly-192 206-CysMetLysAsnPro-210 224-GlyTyrIleValAlaLeu-229 236-PheSerAlaLeuGlnAsnLeuPro-243 271-LeuSerValPheGluAlaValGlyAspLeuThrAla-282 297-ThrLysArgLeuArgGlyGlyVal-304 307-AspGlyLeuValSerValIleAlaThrAlaLeuGly-318 338-AlaSerArgHisValGlyLysTyr-345 361-ArgAlaPheThrThrIleProSerProVal-370 Antigenic Index - Jameson-WoIf l-MetSerGlyGlnLeuGlyLysGlyAlaAspAlaPro-12 18-LeuGluAspArgProProPheGlyAsn-26 80-AsnArgPheGlyPro-84 108-AlaGlyMetLysGluGlyGlyLeuThrLysAspAlaMet-120 177-PheGlyAlaLysAlaAspGlyThrPheGlySer-187 207-MetLysAsnProLeuLeuArg-213 286-ValSerAspGlnProIleGluGlyGluGluTyrThrLysArgLeuArgGlyGlyValLeu-305 391-ValSerHisGlyIleArgArgArgGluAlaVal-401 445-LeuProGluAspLysThrGluAlaAlaValLysPheAspThrAspHisLeuGluHis-463 Hydrophilic Regions - Hopp-Woods 4-GlnLeuGlyLysGlyAlaAspAlaPro-12 18-LeuGluAspArgProProPhe-24 109-GlyMetLysGluGlyGlyLeuThrLysAspAlaMet-120 179-AlaLysAlaAspGly-183 289-GlnProIleGluGlyGluGluTyrThrLysArgLeuArgGly-302 394-GlyIleArgArgArgGluAlaVal-401 445-LeuProGluAspLysThrGluAlaAlaValLysPheAspThrAspHisLeuGluHis-463 537-2 AMPHI Regions - AMPHI 38-GlnIleArgAspGlyGlyAspAlaLeuHisTyrLeuAsnArgIle-52 86-HisGlyGluHisHis-90 109-GlyTyrLeuTyrAsnGlyValHisGlu-117 138-ArgGlnValAspGlyLeuMetSerAlaIleTyr-148 182-ArgPheGluArgHisCys-187 194ProGluAlaGlyArgLysTyrTyrArgAsnAla-204 281-ArgProValArgValLeuThrAlaGly-289 315-TyrThrAlaValPheAspTyrValArgAsnGlyArgArgAla-328 Antigenic Index - Jameson-Wolf 21-ThrGlnAsnGlnSerLeuProAlaGly-29 32-ValTyrProSerAlaProGlnIleArgAspGlyGlyAspAla-45 69-AsnSerAlaArgArgHisAlaSer-76 80-LeuAsnProGluAspGlyHisGlyGluHisHisProAspAsnProHis-95 99-GlnLysLeuThrGluArgThrArgLeu-107 115-ValHisGluAsnIleSerThrGluGluGluAlaAlaGluSerSerAspSerAspIleArgThrGlnGlnArg GlnValAspGlyLeu-143 152-SerLeuLeuAspArgHisThrAspGluAlaGly-162 165-PheValArgGluAsnGlyLysThr-172 178-GlnGlyAsnGlyArgPheGluArgHisCysAlaGlnGlyArgAsnGlnProGluAlaGlyArgLysTyrTyr ArgAsnAlaCysHisAsnGly-208 212-TyrThrAspGluAlaMetPro-218 237-PheHisGlyGluArgProAspProValProGluTyrGluIleThrGlyAsnProAlaSer-256 258-AspPheSerGluAlaAlaGly-264 266-IleThrMetLysSer-270 274-TyrGlnGlyLysAsnGluIleArgPro-282 287-ThrAlaGlyAsnAspProAsnGlyArgLeuThr-297 320-AspTyrValArgAsnGlyArgArgAlaGlnAla-330 334-PheArgThrArgLysProAspTyrProTyr-343 345-GluValAsnGlyGlyGluThrLeuAlaValArgLysGlyGluLys-359 364-TrpArgGlyArgTrpCysLeu-370 376-TyrThrTyrArgGlnArgProGlySerArgLeuSerIleGlyArgHisGluAlaGlyGly-395 401-AspGlyMetAlaGlySer-406 408-IleThrLeuAlaProGluGlyGluThrGluArgGly-419 Hydrophilic Regions - Hopp-Woods 37-ProGlnIleArgAspGlyGlyAsp-44 69-AsnSerAlaArgArgHisAla-75 81-AsnProGluAspGlyHisGlyGluHisHisProAsp-92 100-LysLeuThrGluArgThrArgLeu-107 119-IleSerThrGluGluGluAlaAlaGluSerSerAspSerAspIleArgThrGlnGlnArgGlnValAsp-14 1 152-SerLeuLeuAspArgHisThrAspGluAlaGly-162 165-PheValArgGluAsnGlyLys-171 179-GlyAsnGlyArgPheGluArgHisCysAlaGlnGlyArgAsnGlnProGluAlaGlyArgLysTyrTyrArg -202 238-HisGlyGluArgProAspProValProGlu-247 258-AspPheSerGluAlaAlaGly-264 266-IleThrMetLysSer-270 275-GlnGlyLysAsnGluIleArgPro-282 289-GlyAsnAspProAsnGlyArg-295 323-ArgAsnGlyArgArgAlaGlnAla-330 334PheArgThrArgLysProAsp-340 352-LeuAlaValArgLysGlyGluLys-359 377-ThrTyrArgGlnArgProGlySer-384 387-SerIleGlyArgHisGluAla-393 412-ProGluGlyGluThrGluArgGly-419 538-2 AMPHI Regions - AMPHI 42-ThrAlaLeuAlaGluAlaValGluLeuValLysAlaAlaGly-55 79-LysAlaAlaGluLeuSerGluAlaValAla-88 145-GlnLeuSerHisLeuAlaGlyArgLeuIleArgGlyTyrGlyHisLeuGln-161 188-IleAsnAlaLeuLysLysGlnLeuAla-196 211-SerGlyThrIleLysThrPheAlaLeuValGlyTyrThrAsn-224 231-PheAsnArgLeuThrLys-236 271-GlyPheValSerAspLeuProHisLysLeuIleSerAlaPheSerAlaThrLeuGlu-289 307-AsnSerGlyGlnGlnIleGluAspValGluAsnValLeuGlnGluIleHis-323 365-GluAsnThrGlyIleAspAlaLeuArgGluAlaIleAlaGluSerCysAla-381 Antigenic Index - Jameson-Wolf l-MetThrGlyArgThrGlyGlyAsnGlySerThrGlnAlaGlnProGluArg-17 24-MetLeuAspLysAspGlyThrGlySerSerAlaAlaArg-36 48-ValGluLeuValLys-52 54-AlaGlyGlyAspSerValArgValGluThrAlaLysArgAspArgProHisThr-71 77-ThrGlyLysAlaAlaGluLeuSerGlu-85 100-GluLeuThrProThrGlnGluArgAsnLeuGluLysGluLeuLysCysArgValLeuAsp-119 129-AlaArgArgAlaArgThrGlnGluGlyArgLeuGlnVal-141 161-GlnSerGlnArgGlyGlyIleGlyMetLysGlyProGlyGluThrLysLeuGluThrAspArgArgLeuIle -184 189-AsnAlaLeuLysLysGlnLeuAlaAsnLeuLysLysGlnArgAlaLeuArgArgLysSerArgGluSerGly ThrIleLysThr-216 224-AsnValGlyLysSerSerLeu-230 233-ArgLeuThrLysSerGlyIleTyrAla-241 257-TyrIleSerProGluCys-262 287-ThrLeuGluGluThrAlaGln-293 304-AlaAlaProAsnSerGlyGlnGlnIleGluAspValGluAsnValLeu-319 323-HisAlaGlyAspIlePro-328 333-TyrAsnLysThrAspLeuLeuProSerGluGluGlnAsnThrGlylle-348 365-GluAsnThrGlyIleAspAlaLeuArgGluAlaIleAla-377 380-CysAlaAlaAlaProAsnThrAspGluThrGluMetPro-392 Hydrophilic Regions - Hopp-Woods l-MetThrGlyArgThrGlyGly-7 13-AlaGlnProGluArg-17 25-LeuAspLysAspGlyThrGly-31 48-ValGluLeuValLys-52 54-AlaGlyGlyAspSerValArgValGluThrAlaLysArgAspArgProHis-70 78-GlyLysAlaAlaGluLeuSerGlu-85 101-LeuThrProThrGlnGluArgAsnLeuGluLysGluLeuLysCysArgValLeuAsp-119 129-AlaArgArgAlaArgThrGlnGluGlyArgLeuGlnVal-141 161-GlnSerGlnArgGlyGlyIle-167 171-GlyProGlyGluThrLysLeuGluThrAspArgArgLeuIle-184 189-AsnAlaLeuLysLysGlnLeuAlaAsnLeuLysLysGlnArgAlaLeuArgArgLysSerArgGluSerGly Thr-213 287-ThrLeuGluGluThrAlaGln-293 310-GlnGlnIleGluAspValGluAsnValLeu-319 337-AspLeuLeuProSerGluGluGlnAsn-345 370-AspAlaLeuArgGluAlaIleAla-377 384-ProAsnThrAspGluThrGluMetPro-392 539-2 AMPHI Regions - AMPHI 18-ArgGlnArgGluHisHisArgLeu-25 44-LeuValGlyGlyPheAspPheLeuArgValIleGlyCysGlyGlyValAlaTyrLeuProAspPheGlnGln- 67 Antigenic Index - Jameson-Wolf l-MetGluAspLeuGlnGluIleGly-8 15-LysValGlyArgGlnArgGluHisHisArgLeuHisHisProGlnProGlyAsnGlyGluAlaAspAsp-37 63-ProAspPheGlnGlnAsnValGlyLysAlaAsp-73 77-ValProAspAspAlaAlaAla-83 88-IleGluValAspAlaAspAspAlaValCys-97 102-LeuPheAspGlnProAspAlaGlyGlyAlaGlyAspAlaAlaGluHis-117 Hydrophilic Regions - Hopp-Woods l-MetGluAspLeuGlnGluIleGly-8 15-LysValGlyArgGlnArgGluHisHisArg-24 31-GlyAsnGlyGluAlaAspAsp-37 69-ValGlyLysAlaAsp-73 78-ProAspAspAlaAlaAla-83 88-IleGluValAspAlaAspAspAlaValCys-97 102-LeuPheAspGlnProAspAlaGlyGlyAlaGlyAspAlaAlaGluHis-117 542-2 AMPHI Regions - AMPHI 6-ArgIleArgArgCysSerVal-12 Antigenic Index - Jameson-Wolf l-MetProLysTrpSerArgIleArgArgCysSerVal-12 37-ValArgLeuLysSerSerAspGlyIleAlaSer-47 56-GlyProMetProSerGluThrValSerHisLysSerAspSerSerArgAsnThrSerAlaSerArgArgAsnV alSerProLysCysProPhe-86 90-PheArgGlnAspAlaAlaLysProArgArgPheGlyGlyLys-103 107-LeuThrGlySerArg-111 Hydrophilic Regions - Hopp-Woods 5-SerArgIleArgArgCysSer-ll 37-ValArgLeuLysSerSerAspGlyIleAla-46 58-MetProSerGluThrValSerHisLysSerAspSerSerArgAsnThrSerAlaSerArgArgAsnValSerP ro-82 90-PheArgGlnAspAlaAlaLysProArgArgPheGlyGly-102 544-2 AMPHI Regions - AMPHI ll-AlaLeuIleGlyIleLeu-16 55-PheTrpPheProSerCysProGlyCysValSerGluMetProLysIleIleLysThrAla-74 85-LeuAlaValAlaGlnProIleAspProIleGluSerValArgGlnTyrVal-101 116-LysAlaValGlyGlnAlaPhe-122 Antigenic Index - Jameson-Wolf l-MetLysLysIleLeu-5 22-IleProAspSerLysThrAlaPro-29 35-AspLeuHisGlyLysThrValSerAsnAlaAspLeuGlnGly-48 59-SerCysProGlyCys-63 66-GluMetProLysIleIleLysThrAlaAsnAspTyrLysAsnLysAsnPhe-82 90-ProIleAspProIleGluSerValArgGlnTyrValLysAspTyrGly-105 113-AspAlaAspLysAlaVal-118 133-IleGlyLysLysGlyGluIleLeu-140 144-ValGlyGluProAspPheGlyLysLeuTyrGlnGluIleAspThrAlaTrpArgAsnSerAspAlaVal-16 6 Hydrophilic Regions - Hopp-Woods l-MetLysLysIleLeu-5 23-ProAspSerLysThr-27 66-GluMetProLysIleileLysThrAlaAsnAspTyrLysAsnLysAsn-81 92-AspProIleGluSerValArgGlnTyrValLys-102 113-AspAlaAspLysAlaVal-118 133-IleGlyLysLysGlyGluIle-139 156-1leAspThrAlaTrpArgAsnSerAspAlaVal-166 547-2 AMPHI Regions - AMPHI 7-PheAsnLysThrValAlaSerPheAlaGlnIleValGluThrPheAspVal-23 62-AsnArgSerPheLys-66 105-LeuHisIlePheThrAsnIle-lll 121-GluLeuLeuThrIleLeuValLys-128 Antigenic Index - Jameson-Wolf 3-ValAspAsnGlyPheAsnLysThrVal-ll 35-GlnMetLysGlnArgCysGly-41 53-PheProArgCysGlyPheGluIleProAsnArgSerPheLysGlu-67 76-LeuSerGluArgPheArgThrAsnAlaGluValGluMet-88 129-AsnLeuSerProAsnGlyLysLysArgPhe-138 Hydrophilic Regions - Hopp-Woods 36-MetLysGlnArgCys-40 60-IleProAsnArgSerPheLysGlu-67 76-LeuSerGluArgPheArgThrAsnAlaGluValGluMet-88 130-LeuSerProAsnGlyLysLysArgPhe-138 548-2 (from 23) AMPHI Regions - AMPHI 14-ValLeuAlaAlaLeuAlaAlaCysLys-22 39-SerAlaAlaGluAsnAlaAlaLysPro-47 89-PheThrHisCysProAspValCysProThr-98 103-TyrSerAspThrLeuLysGlnLeuGlyGlyGln-113 132-GluIleIleGlyLysTyrAlaLys-139 Antigenic Index - Jameson-Wolf 21-CysLysProGlnAspAsnSerAlaAla-29 39-SerAlaAlaGluAsnAlaAlaLysProGlnThrArgGlyThrAspMetArgLysGluAspIleGlyGlyAspP eThrLeuThrAspGlyGluGlyLysProPheAsn-74 76-SerAspLeuLysGly-80 91-HisCysProAspValCysPro-97 104-SerAspThrLeuLysGlnLeuGlyGlyGlnAlaLysAspValLys-118 124-IleAspProGluArgAspThrProGluIleIleGlyLysTyrAlaLysGlnPheAsnProAspPhe-145 150-AlaThrGlyGlyGln-154 169-LysValAsnGlnLysAspAspSerGluAsnTyrLeu-180 189-LeuIleAspLysAsnGlyGlu-195 200-SerProTyrGlySerGluProGluThrIleAlaAlaAspVal-213 Hydrophilic Regions - Hopp-Woods 22-LysProGlnAspAsnSerAla-28 39-SerAlaAlaGluAsnAlaAlaLysProGlnThrArgGlyThrAspMetArgLysGluAspIleGlyGly-61 64-ThrLeuThrAspGlyGluGlyLysPro-72 76-SerAspLeuLysGly-80 lll-GlyGlyGlnAlaLysAspValLys-118 124-IleAspProGluArgAspThrProGluIleIle-134 169-LysValAsnGlnLysAspAspSerGluAsnTyrLeu-180 191-AspLysAsnGlyGlu-195 203-GlySerGluProGluThrIleAlaAlaAspVal-213 548-2 (from earlier--to be deleted) AMPHI Regions - AMPHI 14-ValLeuAlaAlaLeuAlaAlaCysLys-22 39-SerAlaAlaGluAsnAlaAlaLysPro-47 89-PheThrHisCysProAspValCysProThr-98 103-TyrSerAspThrLeuLysGlnLeuGlyGlyGln-113 132-GluIleIleGlyLysTyrAlaLys-139 Antigenic Index - Jameson-Wolf 21-CysLysProGlnAspAsnSerAlaAla-29 39-SerAlaAlaGluAsnAlaAlaLysProGlnThrArgGlyThrAspMetArgLysGluAspIleGlyGlyAspP heThrLeuThrAspGlyGluGlyLysProPheAsn-74 76-SerAspLeuLysGly-80 91-HisCysProAspValCysPro-97 104-SerAspThrLeuLysGlnLeuGlyGlyGlnAlaLysAspValLys-118 124-IleAspProGluArgAspThrProGluIleIleGlyLysTyrAlaLysGlnPheAsnProAspPhe-145 150-AlaThrGlyGlyGln-154 169-LysValAsnGlnLysAspAspSerGluAsnTyrLeu-180 189-LeuIleAspLysAsnGlyGlu-195 200-SerProTyrGlySerGluProGluThrIleAlaAlaAspVal-213 Hydrophilic Regions - Hopp-Woods 22-LysProGlnAspAsnSerAla-28 39-SerAlaAlaGluAsnAlaAlaLysProGlnThrArgGlyThrAspMetArgLysGluAspIleGlyGly-61 64-ThrLeuThrAspGlyGluGlyLysPro-72 76-SerAspLeuLysGly-80 lll-GlyGlyGlnAlaLysAspValLys-118 124-IleAspProGluArgAspThrProGluIleIle-134 169-LysValAsnGlnLysAspAspSerGluAsnTyrLeu-180 191-AspLysAsnGlyGlu-195 203-GlySerGluProGluThrIleAlaAlaAspVal-213 552-1 AMPHI Regions - AMPHI 18-CysThrAsnAlaPheAlaAlaPro-25 29-AlaSerLeuAlaArgTrpLeuAspThr-37 41-AspArgAspIleGluLysAsnMetIleGluGlyPheAsnAlaGlyPheLysProTyrAlaAspLysAlaLeuA laGluMet-67 75-AlaAlaGluAlaPheAsnArgTyrArgGluAsnVal-86 89-AspLeuIleThrProGluValLys-96 116-IleAspGlyMetIleAla-121 139-IleLysLysSerMetSerGluIle-146 154-SerGlyLysIleAlaGlnHisHisLeuProGluPheThrGluGluLeuArgArg-171 Antigenic Index - Jameson-Wolf 25-ProProSerAspAlaSerLeu-31 35-LeuAspThrGlnAsnPheAspArgAspIleGluLysAsnMetIle-49 58-ProTyrAlaAspLysAlaLeuAlaGluMetProGluAlaLysLysAspGlnAlaAla-76 78-AlaPheAsnArgTyrArgGluAsnValLeu-87 90-LeuIleThrProGluValLysGlnAlaVal-99 105-LysAsnAlaArgGluIleTyrThrGlnGluGluIleAspGly-118 131-ValValAlaLysAsnProArgLeuIleLysLysSerMetSer-144 153-LeuSerGlyLysIle-157 164-GluPheThrGluGluLeuArgArg-171 173-IleCysGlyGlyLysAsnProAspAlaGlyCysLysGlnAlaGlyGlnValGlyLysArgHisGlnLys-19 5 Hydrophilic Regions - Hopp-Woods 26-ProSerAspAlaSerLeu-31 38-GlnAsnPheAspArgAspIleGluLysAsnMetIle-49 58-ProTyrAlaAspLysAlaLeuAlaGluMetProGluAlaLysLysAspGlnAlaAla-76 78-AlaPheAsnArgTyrArgGluAsnValLeu-87 90-LeuIleThrProGluValLysGlnAlaVal-99 105-LysAsnAlaArgGluIleTyrThr-112 114-GluGluIleAspGly-118 131-ValValAlaLysAsnProArgLeuIleLysLysSerMetSer-144 164-GluPheThrGluGluLeuArgArg-171 176-GlyLysAsnProAspAlaGlyCysLysGlnAlaGlyGlnValGlyLysArgHisGlnLys-195 553-2 AMPHI Regions - AMPHI 31-LeuThrSerIleLeuSerTyrTyrGly-39 59-AsnLeuAlaAspIleMetArgPheGlyAsn-68 83-GluLeuSerAsnLeu-87 Antigenic Index - Jameson-Wolf 10-GlyPheAsnLysLysLeuPro-16 42-ThrAspLeuArgThrLeuArgGlnLysTyr-51 56-LysGlyAlaAsnLeu-60 65-ArgPheGlyAsnGluMetAsnLeuThrProArgAlaLeuArgLeuGluLeuAspGluLeuSerAsn-86 105-SerIleSerLysAspSerIle-lll 116-ProAlaValGlyMetArgLysIleLysMetAspGluValSerGlnLys-131 143-ThrHisPheGluGluLysLysGluThrLysLysIleLys-155 160-LeuArgGlyGlyGlnAla-165 Hydrophilic Regions - Hopp-Woods 42-ThrAspLeuArgThrLeuArgGln-49 75-ArgAlaLeuArgLeuGluLeuAspGluLeuSer-85 106-IleSerLysAspSer-llO 118-ValGlyMetArgLysIleLysMetAspGluValSerGln-130 144-HisPheGluGluLysLysGluThrLysLysIleLys-155 554 AMPHI Regions - AMPHI 35-AlaProThrPheGlnThrProGluThrLeu-44 71-AlaAlaLeuThrGlnLeuMet-77 110-ArgMetPheValArgProGlyAspThrVal-119 124-LeuLeuLysGlyMet-128 148-SerIleGluAsnPheValGlnGlnMetAsnLysGlu-159 193-GluAlaLeuMetArgAspPheProGluTyrTyrProLeuPheSer-207 296-ThrValAlaGlnIle-300 331-GluGlnIleLeuGluThrIleGlnProIleProAla-342 Antigenic Index - Jameson-Wolf 24-SerProAlaProAsnArgProThrVal-32 37-ThrPheGlnThrProGluThr-43 53-LeuGlnSerLysGln-57 61-AlaLysAsnIleAsnThrProValGlu-69 84-LysAsnMetLysSerGlyAsnIleGlnSerGluGluAsnLeuLysIleProGlu-101 104-TrpAlaSerGluGlySerArgMetPheValArgProGlyAspThrValΞerThrAspLysLeuLeu-125 143-ArgLeuGlyAsnGlySerIleGluAsnPhe-152 156-MetAsnLysGluAlaArgArgLeuGlyMetLysAsnThrValPheLysAsnProThrGlyLeuΞerArgGlu GlyGlnValSerThrAlaLysAsp-187 194-AlaLeuMetArgAspPheProGluTyrTyr-203 214-LysAsnIleGluGlnAsnAsnArgAsnIleLeu-224 226-TyrArgAspAsnAsnValAsnGlyLeuLysAlaGlyHisThrGluSerGlyGlyTyrAsn-245 250-TyrSerGlyAsnGlyArgHis-256 262-LeuGlySerGluSerAlaGluThrArgAlaSerAspAsnSerLys-276 285-PheAspThrProLysIleTyrProLysGlyLysThr-296 302-IleSerGlyGlySerLysLysThrValArg-311 323-ProHisLysGluAlaLysMetAlaGluGlnIleLeu-334 342-AlaProValLysLysGlyGlnIleLeuGlyLysIleLysIleArgGlnAsnGlyTyr-360 362-IleAlaGluLysGluIleValAla-369 371-GluAsnValLysLysArgSerArgTrpGlnArg-381 Hydrophilic Regions - Hopp-Woods 26-AlaProAsnArgProThr-31 85-AsnMetLysSerGlyAsnIleGlnSerGluGluAsnLeuLysIleProGlu-101 107-GluGlySerArgMetPheValArgProGlyAspThrValSerThrAspLysLeuLeu-125 156-MetAsnLysGluAlaArgArgLeuGlyMet-165 174-ThrGlyLeuSerArgGluGlyGlnValSerThrAlaLysAsp-187 214-LysAsnl1eGluGlnAsnAsnArg-221 227-ArgAspAsnAsnValAsn-232 237-GlyHisThrGluSerGly-242 264-SerGluSerAlaGluThrArgAlaSerAspAsnSerLys-276 289-LysIleTyrProLysGlyLysThr-296 304-GlyGlySerLysLysThrValArg-311 323-ProHisLysGluAlaLysMetAlaGluGlnIleLeu-334 343-ProValLysLysGlyGlnIle-349 353-IleLysIleArgGln-357 362-IleAlaGluLysGluIleValAla-369 371-GluAsnValLysLysArgSerArgTrp-379 556 AMPHI Regions - AMPHI 61-IleGluArgLeuLys-65 Antigenic Index - Jameson-Wolf l-Me AspAsnLysThrLysLeuArgLeu-9 52-ThrSerArgArgGlnGlnArgGlnPheIleGluArgLeuLysLysPheAspIleAspProGluLysGlyArgI leAsnGluAlaAsnLeuArgArgMetTyrHisSerGlyGlyGlnHisGlnLysAspAla-95 102-SerGlnLysCysSerValAspGluAlaHisAlaMetPheLysLysArgProThrArgGlnGluIleAsn-12 4 127-AlaAlaLysGlnSerArgGlyGlnLysArgProHisArg-139 Hydrophilic Regions - Hopp-Woods l-MetAspAsnLysThrLysLeuArgLeu-9 53-SerArgArgGlnGlnArgGlnPheIleGluArgLeuLysLysPheAspIleAspProGluLysGlyArgIleA snGluAlaAsnLeuArgArgMetTyr-85 90-GlnHisGlnLysAspAla-95 105-CysSerValAspGluAlaHisAlaMetPheLysLysArgProThrArgGlnGluIleAsn-124 127-AlaAlaLysGlnSerArgGlyGlnLysArgProHisArg-139 557 AMPHI Regions - AMPHI 22-GlyAlaAspGlyIle-26 55-SerGlyArgValAspAspAlaAla-62 Antigenic Index - Jameson-Wolf 20-LeuLysGlyAlaAspGlyIleSerProProLeuThrTyrArgSerTrpHisIleGluGlyGlyGlnAlaLeuA rg-44 54-AlaSerGlyArgValAspAspAlaAlaGly-63 68-LeuArgIleAspSerValSerGlnAsnLysGluThrTyrThr-81 100-GlnValLeuLysArgGlyGluProValGlyLysProMet-112 123-AlaAspAsnGluIleLeuGlyLysGlnGluGluGluAla-135 141-MetArgGlnAspAlaAlaGluGlnIleValArg-151 Hydrophilic Regions - Hopp-Woods 21-LysGlyAlaAspGlyIle-26 56-GlyArgValAspAspAlaAlaGly-63 68-LeuArgIleAspSerValSerGlnAsnLysGluThrTyrThr-81 100-GlnValLeuLysArgGlyGluProValGly-109 126-GluIleLeuGlyLysGlnGluGluGluAla-135 141-MetArgGlnAspAlaAlaGluGlnIleValArg-151 560 AMPHI Regions - AMPHI 30-PheArgAspGlyAlaHisLysMetAlaArgValTrpValGly-43 167-ArgMetAlaLysMetPhe-172 192-PheLeuLysTyrProGlyGlu-198 216-GluLeuMetGluLysCysGluHisLeuIleGlu-226 Antigenic Index - Jameson-Wolf 29-ProPheArgAspGlyAlaHisLysMet-37 61-GlyAlaGluAsnIleProAspArgProAla-70 76-HisGlnSerGlyTrpGlu-81 95-ValAlaLysArgGluLeuPhe-101 116-IleGlyIleAspArgAsnAsnArgArgGluAlaAsnGluGlnLeuIle-131 134-GlyLeuValArgLysAsnGluGlyTyr-142 148-ProGluGlyThrArgLeuAlaProGlyLysArgGlyLysTyrLysLeuGlyGly-165 182-AsnSerGlyGluPheTrpProLysAsnSerPheLeuLysTyrProGlyGluIle-199 209-HisAlaSerGlySerGluAlaGluLeuMetGluLysCysGluHisLeuIle-225 242-MetProSerGluThrAla-247 Hydrophilic Regions - Hopp-Woods 29-ProPheArgAspGlyAlaHisLysMet-37 64-AsnIleProAspArgProAla-70 95-ValAlaLysArgGluLeuPhe-101 116-IleGlyIleAspArgAsnAsnArgArgGluAlaAsnGluGlnLeuIle-131 134-GlyLeuValArgLysAsnGlu-140 149-GluGlyThrArgLeuAlaProGlyLysArgGlyLysTyrLysLeuGlyGly-165 211-SerGlySerGluAlaGluLeuMetGluLysCysGluHisLeuIle-225 242-MetProSerGluThrAla-247 561 AMPHI Regions - AMPHI 22-GlyLeuTrpValGlyLeuAlaAla-29 46-AlaSerValIleGluGluAlaGlyAsn-54 79-ValAlaGluPheGluLysSerLeuLysArgIleAlaGln-91 128-SerTyrArgArgProThrGlnVal-135 172-MetThrLeuValSerSer-177 188-ValIleArgProLeuGlnAlaLeuArgGluGlyAlaGluArgIleGlyArgArgCysPheAspIle-209 219-PheLysGlnValGlyArgCysPheAsnGlnMet-229 238-AspAspLeuGluGlyGlnValAlaGluGlnThrArgSerLeuGluLysGln-254 265-ThrArgAspLeuHisGlnSer-271 275-GlnGlnAlaAlaGluHisPhe-281 283-AsnArgIleLeuPro-287 317-AlaSerAspLeuGlyLysTyrHisGlu-325 339-ArgLeuLeuLeuSerPheProAsnGly-347 358-LeuGlnThrLeuGlyArgGlnLeuGly-366 392-GlnGlyLeuHisAspSerIleAlaGlnAlaLeuThr-403 434-GlyValGlnGluCysTyrGluAspValArgGluLeu-445 456-LysGluPheProGluAlaValAlaAspLeuPheAlaArgPhe-469 504-LeuSerAsnIleArgLysHisAlaArg-512 540-ThrGluLysIleGlyGluProThr-547 Antigenic Index - Jameson-Wolf 6-ArgPheSerAspGlyIleSer-12 48-ValIleGluGluAlaGlyAsn-54 66-AlaGlyGluGlySerProArgAlaGlnIleAspAsnGlnValAlaGluPheGluLysSerLeuLysArgIleA laGlnSerAspAlaIleHisPro-97 99-IleProSerAspThrProLeu-105 124-ProProLeuGlnSerTyrArgArgProThrGlnValAspLeu-137 152-GluAsnAlaAsnGluLysAsnThr-159 193-GlnAlaLeuArgGluGlyAlaGluArgIleGlyArgArgCysPheAsp-208 210-ProValProGluGlyGlyThrProGluPheLysGlnValGlyArgCysPheAsnGlnMetGlyGlyArgLeu LysIleLeuTyrAspAspLeuGluGlyGlnValAlaGluGlnThrArgSerLeuGluLysGlnAsnGlnAsnLeu- 258 263-GlnThrThrArgAspLeuHisGlnSerTyrIle-273 289-ValGlyAlaAspSerGlyArgValCysLeuAspGlyGlySerAsp-303 310-HisAlaAspCysGlyThrAlaAlaSerAspLeuGlyLysTyrHisGlu-325 332-TyrGlnAsnGluThrLeuGly-338 344-PheProAsnGlyIleSerLeuAspGluAspAspArgIleLeu-357 360-ThrLeuGlyArgGlnLeu-365 371-GlyAlaLysGlnGluGluGluLysArgLeu-380 384-LeuGlnGluArgAsnLeu-389 394-LeuHisAspSerIle-398 415-AlaPheAlaGluAsnLysArgGluGluAlaAlaGlu-426 434-GlyValGlnGluCysTyrGluAspValArgGlu-444 450-ArgThrLysIleSerAsnLysGluPheProGluAlaVal-462 480-AlaTrpGluAsnGlySer-485 488-ProProGlnGluAla-492 503-SerLeuSerAsnIleArgLysHisAlaArg-512 519-ThrLeuSerGluHisGlyGlyArgPhe-527 531-IleGlnAspAsnGlyGlnGlyPheAspThrGluLysIleGlyGluProThrGlySerHis-550 556-MetGlnGluArgAlaLysArgIle-563 568-GluIleArgSerGlnAlaGlnGlnGlyThrThr-578 584-AlaSerGluGluSerLeuLys-590 Hydrophilic Regions - Hopp-Woods 48-ValIleGluGluAlaGlyAsn-54 68-GluGlySerProArgAlaGlnIle-75 78-GlnValAlaGluPheGluLysSerLeuLysArgIleAlaGln-91 128-SerTyrArgArgProThrGln-134 152-GluAsnAlaAsnGluLys-157 193-GlnAlaLeuArgGluGlyAlaGluArgIleGlyArgArgCysPhe-207 213-GluGlyGlyThrProGluPheLysGlnValGly-223 235-IleLeuTyrAspAspLeuGluGlyGlnValAlaGluGlnThrArgSerLeuGluLysGlnAsnGln-256 264-ThrThrArgAspLeuHis-269 290-GlyAlaAspSerGlyArgValCysLeu-298 312-AspCysGlyThrAlaAlaSerAspLeuGlyLysTyrHisGlu-325 349-SerLeuAspGluAspAspArgIleLeu-357 371-GlyAlaLysGlnGluGluGluLysArgLeu-380 384-LeuGlnGluArgAsnLeu-389 415-AlaPheAlaGluAsnLysArgGluGluAlaAlaGlu-426 437-GluCysTyrGluAspValArgGlu-444 451-ThrLysIleSerAsnLysGluPheProGluAlaVal-462 503-SerLeuSerAsnIleArgLysHisAlaArg-512 533-AspAsnGlyGlnGlyPheAspThrGluLysIleGlyGluProThrGly-548 556-MetGlnGluArgAlaLysArgIle-563 568-GluIleArgSerGlnAlaGln-574 584-AlaSerGluGluSerLeuLys-590 562 AMPHI Regions - AMPHI 48-TrpSerLeuValSerAlaTrpMetValValIle-58 84-LeuGluThrThrValMetSerAlaValArgThrLeu-95 97-PheThrProTyrThrThrValAlaSerThrSer-107 116-ThrPhePheAlaProLeuSerArgTrp-124 133-AsnAlaProValHisSerMetThrLysSerThrProΞerSerPheHis-148 184-ValSerAsnLeuValArgTrpAlaLeu-192 Antigenic Index - Jameson-Wolf 9-PheAsnSerGlySerThrLysProThr-17 32-ProLeuArgAlaArgArgArgSerLeuTrpArg-42 72-AlaThrGlyGluArgGlnLeuVal-79 105-SerThrSerSerProProGlyAlaGluMet-114 139-MetThrLysSerThrProSerSerPheHisGlySerSerAla-152 154-LeuArgValGluLysLysGlyIleLeuSerProLeuThr-166 168-ArgLeuProProSerTrpAspThrSerAlaSerLysArgProCysThr-183 Hydrophilic Regions - Hopp-Woods 33-LeuArgAlaArgArgArgSerLeuTrp-41 72-AlaThrGlyGluArgGlnLeuVal-79 110-ProGlyAlaGluMet-114 140-ThrLysSerThrPro-144 154-LeuArgValGluLysLysGlyIle-161 176-SerAlaSerLysArgProCysThr-183 563 AMPHI Regions - AMPHI 24-ThrLysArgGluGlyLys-29 120-AsnGlnTyrAlaGlnPhe-125 164-ValAsnGlnIleAsnSerSerHisSerSer-173 246-AspPheThrArgl1eLeuSerTyrHisSer-255 290-AlaAlaAsnThrSerAsnAsnThrAla-298 313-LysLeuGlyGlyMetTyr-318 366-LysAspThrAspAsn-370 443-AsnAsnGlnGlyLysLeu-448 483-SerSerAsnGlnThrGlyAsn-489 516-SerAsnIleThrAlaProThr-522 529-ArgThrHisGlyAlaLeuAsp-535 551-GlnGlnGlyLeuAsnAsnAlaGlyGlnIle-560 611-LeuAspAsnAlaHisGlyLysLeuLeuSerAla-621 736-LeuAspAsnAlaAlaGlnGly-742 775-GlnMetAsnAsnIleGlyThr-781 848-ThrGlyLysAlaGlnArgIleHisAsnAlaGlyAlaThrIleGlu-862 874-LeuHisAsnThrAsnGlu-879 896-TyrGluAlaPheGlyArg-901 922-SerAspHisLeuArgThrProAspGlyAlaAlaHisGluAsnTrp-936 953-ThrAlaProAlaLys-957 1011-LeuHisSerTyrTrpArg-1016 1036-GluGluIleThrArg-1040 1131-LeuHisLysArgLeuGlyAspGlyTyr-1139 1147-GluGlnIleAlaGluLeuThrGlyHisArgArgLeuAspGlyTyrGlnAsn-1163 1169-LysAlaLeuMetAsp-1173 1194-GlnValAlaGlnLeu-1198 1272-ThrLeuAspAsnIleGlyGly-1278 1289-AlaThrGlnAspIleAsnAsnIleGlyGlyMetLeu-1300 1376-GlnAlaGlyArgAspIle-1381 1403-IleArgGlySerThrAsnGluValGlySerSer-1413 1461-ValAspAspAlaSerLysHisThrGlyArg-1470 1485-SerHisHisGluThr-1489 1524-GlnAlaGlyAsnHisVal-1529 1539-GlnSerGluThrTyrHisGln-1545 1594-LysHisTyrGluGlnIleGlySerThrVal-1603 1646-ProValThrAspLeuAla-1651 1685-TyrGlnThrGlyLysSerAlaGlnAsnLeuAlaAsnGlyThrThrAsn-1700 1777-GluGlnSerAsnThrGluArgGlyGln-1785 1811-GlyGlyAsnValGlyLysGlyTyrGly-1819 1964-LysAsnHisSerGlnTyr-1969 1987-LeuGlyGlnGlyAlaGlnAsnLysProGln-1996 2064-ThrAspThrAlaGluArgHisSerGlySerLeuLysAsnThrPheAsn-2079 2093-ValSerGlnAspPheSerLysAsnValGln-2102 2161-IleLeuAsnMetLeuAlaSerGlyLeuAla-2170 2193-GlyGlnHisPheLysAspLeuAlaGly-2201 2223-LeuGlyAlaAlaValAla-2228 2275-AlaIleThrAsnValLeuGlyThrAlaThrGly-2285 2289-GlyAsnSerAlaThrAspAlaAla-2296 2332-HisLysAspProGly-2336 2379-IleThrArgGluPheGlyLysAspIleAla-2388 2393-AsnSerHisGluSer-2397 2414-AlaAspGluMetIleAspGlnLeuAsnAsnGluIle-2425 Antigenic Index - Jameson-Wolf l-MetAsnLysThrLeu-5 9-IlePheAsnArgLysArgGlyAlaVal-17 22-GluThrThrLysArgGluGlyLysSerCysAlaAspSerAspSerGlySerAlaHis-40 83-IleIleAlaAspLysAlaAlaProLysThrGlnGln-94 127-ValGlyAsnArgGlyAlaIleLeuAsnAsnSerArgSerAsnThrGlnThr-143 152-AsnProTrpLeuAla-156 158-GlyGluAlaArgVal-162 167-IleAsnSerSerHisSerSerGlnMetAsnGly-177 179-IleGluValGlyGlyArgArgAlaGluVal-188 205-AsnAlaSerArgAlaThrLeu-211 213-ThrGlyGlnProGlnTyrGlnAlaGlyAspLeuSerGlyPheLysIleArgGlnGlyAsn-232 239-GlyLeuAspAlaArgAspThrAspPhe-247 252-SerTyrHisSerLysIleAspAla-259 264-GlnAspValArgVal-268 292-AsnThrSerAsnAsnThrAlaAsnAsnGlyThr-302 310-AspThrGlyLysLeuGlyGly-316 331-AlaGlylleArgAsnGlnGlyGlnLeu-339 349-AspAlaAsnGlyArgLeuValAsn-356 364-AsnAlaLysAspThrAspAsnThrAlaGluHisLysValAsnIleArgSerGlnGlyValGluAsnSerGly ThrAlaValSerGlnGlnGlyThrGlnIleHis-398 400-GlnΞerIleGlnAsnThr-405 418-AsnSerGlySerLeuLysAsnGluThrSerGlyThrIleGluAlaAlaArgLeuAlaIleAspThrAspThr LeuAsnAsnGlnGlyLysLeuSerGlnThrGlySerGlnLysLeuHisIle-458 460-AlaGlnGlyLysMetAspAsnArgGlyArgMetGlyLeuGlnAspThrAlaProThrAlaSerAsnGlySer SerAsnGlnThrGlyAsnSerTyr-491 497-SerSerThrThrThrProThrThr-504 522-ThrPheAlaAspGlyThrIleArgThrHisGlyAlaLeuAspAsnSerGlySer-539 542-AlaAsnGlyGlnThrAspValSerAla-550 552-GlnGlyLeuAsnAsnAlaGlyGln-559 566-AsnAlaLysGlySerAla-571 573-AspAsnHisAsnGly-577 589-GlySerLeuAsnAsnGlnAsnGlyAsnIleThrThrArgGlnGlnLeuGluIleGluThrAspGlnLeuAsp AsnAlaHisGly-616 631-SerLeuAsnAsnGlnAsnGlyGluIleAlaThrAsn-642 646-IleIleHisAspGlyGlnGlnSer-653 659-AsnThrAsnGlyThrIleGlnSerGlyArgAspValAlaIle-672 675-LysSerLeuSerAsnAsnGly-681 685-AlaAspAsnLysLeuAspIleAlaLeu-693 695-AspAspPheTyrValGlu-700 702-AsnIleValAlaGlyAsnGluLeu-709 711-LeuSerThrArgGlySerLeuLysAsnSerHisThr-722 725-AlaGlyLysArgIleArgIleLysAlaAsnAsnLeuAspAsnAlaAlaGlnGlyAsnIleGlnSerGlyGly ThrThrAspIleGlyThrGlnHisAsnLeuThrAsnArgGlyLeuIleAspGlyGlnGlnThrLysIleGln-772 793 -AlaThrArgLeuAspAsnGlnAspGluAsnGlyThrGly-805 809-AlaAlaArgGluAsnLeuAsn-815 821-LeuAsnAsnArgGluAsnSerLeu-828 839-GlyAlaLeuAspThrAsnGlyGlnAlaThrGlyLysAlaGlnArgIleHisAsnAlaGlyAla-859 863-AlaAlaGlyLysMetArgLeuGlyValGluLysLeuHisAsnThrAsnGluHisLeuLys-882 887-GluThrGlyArgGluHisIleVal-894 903-GluLeuLeuArgGluGlyThrGlnHis-911 917-ValTyrAsnAspGluSerAspHisLeuArgThrProAspGlyAlaAlaHis-933 937-HisLysTyrAspTyrGluLysValThrGlnLysThrGlnVal-950 960-SerGlyAsnAspLeuThr11eAspGlyLysGluValPheAsnThrAspSer-976 987-GlnThrGluLysAspGlyLeuHisAsnGluGlnThrPheGlyGluLysLysValPheSerGluAsnGlyLys LeuHisSerTyrTrpArgGluLysHisLysGlyArgAspSerThrGlyHisSerGluGlnAsnTyrThrLeuProG luGluIleThrArgAsn-1041 1050-GluSerHisArgLysAlaLeu-1056 1059-HisAlaProΞerGlnGlyThrGluLeuProGlnSerAsnGlylle-1073 1100-TyrLeuValGluThrAspProArgPheAlaAsn-lllO 1124-LeuLysLeuAspProAsnAsnLeuHisLysArgLeuGlyAspGlyTyrTyrGluGlnArgLeuIleAsn-l 146 1153-ThrGlyHisArgArgLeuAspGlyTyrGlnAsnAspGluGluGlnPheLysAlaLeuMetAspAsnGlyAl aThrAlaAlArgSerMetAsn-1183 1208-LysGluValLysLeuProAspGlyGlyThr-1217 1228-ArgValLysAsnGlyAspIleAspGlyLysGly-1238 1252-GlySerLeuLysAsSerGlyThrIleAlaGlyArgAsnAla-1265 1269-AsnThrAspThrLeuAspAsnIleGlyGly-1278 1280-IleHisAlaGlnLysSerAla-1286 1310-AlaGlyAsnAsnIleAsnSerGlnSerThrThrAlaSerSerGlnAsnThrGlnGlySerSerThrTyrLe u-1333 1342-ThrGlyLysGluLysGlyVal-1348 1353-AlaGlyLysAspIleAsnIle-1359 1364-IleSerAsnGlnSerGluGlnGlyGlnThrArgLeuGlnAlaGlyArgAspIleAsnLeuAspThrValGl nThrSerLysHisGln-1392 1396-PheAspAlaAspAsnHisValIleArgGlySerThrAsnGluValGlySerSerIleGlnThrLysGlyAs pVal-1420 1425-GlyAsnAsnLeuAsnAlaLysAlaAlaGluValSerSerAlaAsnGly-1440 1446-AlaLysAsnAspIle-1450 1459-ThrHisValAspAspAlaSerLysHisThrGlyArgSerGlyGlyGlyAsnLysLeuValIle-1479 1481-AspLysAlaGlnSerHisHisGluThrAlaGlnSerSerThrPheGluGlyLysGln-1499 1503-GlnAlaGlyAsnAspAlaAsn-1509 1515-ValIleSerAspAsnGlyThrGlnIleGlnAla-1525 1532-GlyThrThrGlnThrGlnSerGlnSerGluThrTyrHisGlnThrGlnLysSerGlyLeu-1551 1561-GlySerLysThrAsnThrGlnGluAsnGlnSerGlnSerAsnGluHisThrGlySerThrValGlySerLe uLysGlyAspThrThrIle-1590 1592-AlaGlyLysHisTyrGluGlnIle-1599 1603-ValSerSerProGluGlyAsnAsn-1610 1621-AlaAlaHisAsnLysLeuAsnSerAsnThrThrGlnThrTyrGluGlnLysGlyLeu-1639 1659-GlnSerSerLysGlnValGlyGlnSerLysAsnAspArgValAsn-1673 1684-AlaTyrGlnThrGlyLysSerAlaGln-1692 1694LeuAlaAsnGlyThrThrAsnAlaLys-1702 1710-TyrGlyGluGlnGlnAsnArgGlnThrThrGln-1720 1729-SerGlnIleGlnAlaGlyGlyLysThrThr-1738 1744-AlaAlaGluGlnSerAsn-1749 1754-GlySerAspValAlaGlyLys-1760 1767-AlaAspAsnAspIleThr-1772 1774-GlnSerAlaGluGlnSerAsnThrGluArgGlyGlnAsnLysSerAlaGlyTrpAsn-1792 1812-GlyAsnValGlyLysGlyTyrGlyAsnGlyAspSerIleThrHisArgHisSerHisIleGlyAspLysGl ySer-1836 1841-GlnSerGlyGlyAspThrThrIleLys-1849 1851-AlaGlnValArgGlyLysGlyValGlnValAsnAlaLysAsn-1864 1869-SerValGlnAspArgGlul874ThrTyrGlnSerLysGlnGlnAsnAla-1883 1895-AlaGlyGlyAspTyrSerGlnSerLysIleArgAlaAspHis-1908 1912-ThrGluGlnSerGlyIleTyrAlaGlyGluAspGlyTyrGln-1925 1929-GlyAsnHisThrAspLeuLysGlyGlyIle-1938 1942-ThrGlnSerAlaGluAspLysGlyLyAsnArgPheGln-1954 1959-ThrHisSerAspIleLysAsnHisSerGlnTyrLysGlyGluSerPhe Gly-1975 1982-IleSerGlyLysThrLeuGlyGlnGlyAlaGlnAsnLysProGlnAsnLysHis-1999 2003-ValAlaAspLysAsnSerAlaSer Ser-2011 2014-GlyTyrGlySerAspSerAspSerGlnSerSerIleThrLysSerGlyIleAsnThrArgAsn-2034 2036-GlnIleThrAspGluAlaAlaGln-2043 2045-ArgLeuThrGlyLysThrAlaAlaGlnThrLyAlaAspIleAspThrAsnValThrThrAspThrAlaGlu ArgHisSerGlySerLeuLysAsnThrPheAsnLysGluAlaValGlnSerGluLeuAspLeuGlnArgThrValS erGlnAspPheSerLysAsnValGlnGlnAlaAsnThrGluIle-2108 2110-GlnHisLeuAspLysLeuLysAlaAspLysGluAlaAlaGluThrAlaAla-2126 2131-AlaAsnGlyAspMetGluThrAlaLysArgLysAlaHisGluAlaGlnAspAlaAlaAlaLysAlaAspAs nTrpGlnGln-2157 2172-ProThrGlnSerGly-2176 2195-HisPheLysAspLeuAlaGlyGlnAsnAlaAsnGlyLysLeuThrAlaSerGlnGluThr-2214 2231-GlyAspAsnAsnAla-2235 2241-SerAlaGlyGlySerGluAla-2247 2256-LeuTyrGlyLysGluLysGlySerAspLeuThrAlaGluGluLysGluThrVal-2273 2288-ValGlyAsnSerAlaThrAspAlaAlaGlnGlySerLeuAsnAla-2302 2304-SerAlaValGluAsnAsnAspThrValGluGlnVal-2315 2319-LeuArgHisProArg-2323 2331-ValHisLysAspProGlySerThrLeuGluProAsnIle-2343 2355-PheProAsnSerGluPheGlyGlyGluGlyGlyVal-2366 2379-IleThrArgGluPheGlyLysAspIleAlaVal-2389 2391-ValGlyAsnSerHisGluSerGlyGluLysIleAsnTyrSerIleArgArgAsnLeuSerLeuAspLysAl aAspGluMetIleAsp-2419 2421-LeuAsnAsnGluIleGlyArgGluIleAla-2430 2432-AsnThrAsnArgLeuAsnThrLysGluLeu-2441 2447-GluThrTyrLysAsnAsnGlyPhe-2454 2456-GlnAlaGluArgAsnSerAsnGlyAsnTyrAspValValArgLysArgLeuSerGluLysAspTyrGlnAs nThrSerAsn-2482 2496-IleGlnGlnArgArgLysGlnIleArg-2504 2510-ArgGlnTrpArgArg-2514 Hydrophilic Regions - Hopp-Woods 10-PheAsnArgLysArgGlyAla-16 22-GluThrThrLysArgGluGlyLysSerCysAlaAspSerAspSerGlySerAlaHis-40 83-IleIleAlaAspLysAlaAlaProLysThrGlnGln-94 136-AsnSerArgSerAsnThr-141 158-GlyGluAlaArgVal-162 181-ValGlyGlyArgArgAlaGluVal-188 224-SerGlyPheLysIleArgGln-230 240-LeuAspAlaArgAspThrAspPhe-247 331-AlaGlyIleArgAsn-335 364-AsnAlaLysAspThrAspAsnThrAlaGluHisLysValAsnIleArgSerGlnGlyValGluAsnSerGly -387 420-GlySerLeuLysAsnGluThrSerGlyThrIleGluAlaAlaArgLeuAlaIleAspThrAspThrLeuAsn Asn-444 446-GlyLysLeuSerGln-450 460-AlaGlnGlyLysMetAspAsnArgGlyArgMetGlyLeu-472 481-AsnGlySerSerAsnGlnThr-487 534-LeuAspAsnSerGly-538 544-GlyGlnThrAspValSerAla-550 602-GlnGlnLeuGluIleGluThrAspGlnLeuAspAsnAlaHis-615 635-GlnAsnGlyGluIleAlaThr-641 665-GlnSerGlyArgAspValAlaIle-672 685-AlaAspAsnLysLeuAspIleAlaLeu-693 715-GlySerLeuLysAsn-719 725-AlaGlyLysArgIleArgIleLysAlaAsnAsnLeuAspAsnAlaAla-740 767-GlnGlnThrLysIleGln-772 794-Thr rgLeuAspAsnGlnAspGluAsnGlyThr-804 809-AlaAlaArgGluAsnLeu-814 822-AsnAsnArgGluAsnSer-827 841-LeuAspThrAsnGly-845 847-AlaThrGlyLysAlaGlnArgIleHis-855 863-AlaAlaGlyLysMetArgLeuGlyValGluLysLeuHisAsnThrAsnGluHisLeuLys-882 887-GluThrGlyArgGluHisIleVal-894 903-GluLeuLeuArgGluGlyThrGlnHis-911 919-AsnAspGluSerAspHisLeuArgThrProAspGlyAlaAla-932 939-TyrAspTyrGluLysValThrGln-946 964-LeuThrIleAspGlyLysGluValPheAsn-973 987-GlnThrGluLysAspGlyLeuHisAsn-995 998-ThrPheGlyGluLysLysValPheSerGluAsnGlyLys-1010 1015-TrpArgGluLysHisLysGlyArgAspSerThrGlyHisSerGluGln-1030 1036-GluGluIleThrArg-1040 1050-GluSerHisArgLysAlaLeu-1056 1063-GlnGlyThrGluLeuProGln-1069 1104-ThrAspProArgPheAlaAsn-lllO 1124-LeuLysLeuAspPro-1128 1130-AsnLeuHisLysArgLeuGly-1136 1153 -ThrGlyHisArgArgLeuAspGlyTyrGlnAsnAspGluGluGlnPheLysAlaLeuMet-1172 1175-GlyAlaThrAlaAlaArg-1180 1208-LysGluValLysLeuProAspGlyGlyThr-1217 1229-ValLysAsnGlyAspIleAspGlyLysGly-1238 1252-GlySerLeuLysAsn-1256 1280-IleHisAlaGlnLysSerAla-1286 1324-GlnAsnThrGlnGly-1328 1343-GlyLysGluLysGlyVal-1348 1353-AlaGlyLysAspIleAsn-1358 1366-AsnGlnSerGluGlnGlyGlnThrArgLeuGlnAlaGlyArgAspIleAsnLeu-1383 1387-GlnThrSerLysHisGln-1392 1396-PheAspAlaAspAsnHisVal-1402 1406-SerThrAsnGluValGlySer-1412 1414-IleGlnThrLysGlyAspVal-1420 1428-LeuAsnAlaLysAlaAlaGluValSerSer-1437 1446-AlaLysAsnAspIle-1450 1460-HisValAspAspAlaSerLysHisThrGlyArgSerGlyGlyGly-1474 1481-AspLysAlaGlnSerHisHisGluThrAlaGln-1491 1493-SerThrPheGluGlyLysGln-1499 1537-GlnSerGlnSerGluThr-1542 1562-SerLysThrAsnThrGlnGluAsnGlnSerGlnSerAsnGluHisThrGly-1578 1584-LeuLysGlyAspThr-1588 1604-SerSerProGluGlyAsn-1609 1621AlaAlaHisAsnLysLeuAsnSer-1628 1634-TyrGluGlnLysGly-1638 1659-GlnSerSerLysGlnValGlyGlnSerLysAsnAspArgValAsn-1673 1686-GlnThrGlyLysSerAlaGln-1692 1712-GluGlnGlnAsnArgGlnThrThr-1719 1744-AlaAlaGluGlnSerAsn-1749 1756-AspValAlaGlyLys-1760 1767-AlaAspAsnAspIle-1771 1775-SerAlaGluGlnSerAsnThrGluArgGlyGlnAsnLys-1787 1822-AspSerIleThrHis-1826 1830-HisIleGlyAspLysGlySer-1836 1843-GlyGlyAspThrThrlleLys-1849 1851-AlaGlnValArgGlyLysGlyVal-1858 1869-SerValGlnAspArgGluThrTyrGlnSerLysGlnGlnAsnAla-1883 1897-GlyAspTyrSerGlnSerLysIleArgAlaAspHis-1908 1919-AlaGlyGluAspGlyTyrGln-1925 1932-ThrAspLeuLysGly-1936 1943-GlnSerAlaGluAspLysGlyLysAsnArgPhe-1953 1961-SerAspIleLysAsn-1965 1967-SerGlnTyrLysGlyGluSer-1973 1991-AlaGlnAsnLysProGlnAsnLysHis-1999 2003-ValAlaAspLysAsnSerAla-2009 2017-SerAspSerAspSerGlnSerSerIleThr-2026 2036-GlnIleThrAspGluAlaAlaGln-2043 2050-ThrAlaAlaGlnThrLysAlaAspIleAspThr-2060 2065-AspThrAlaGluArgHisSerGlySerLeu-2074 2077-ThrPheAsnLysGluAlaValGlnSerGluLeuAspLeuGlnArg-2091 2104-AlaAsnThrGluIle-2108 2110-GlnHisLeuAspLysLeuLysAlaAspLysGluAlaAlaGluThrAlaAla-2126 2133-GlyAspMetGluThrAlaLysArgLysAlaHisGluAlaGlnAspAlaAlaAlaLysAlaAspAsn-2154 2195-HisPheLysAspLeuAlaGly-2201 2208-LeuThrAlaSerGlnGluThr-2214 2243-GlyGlySerGluAla-2247 2257-TyrGlyLysGluLysGlySerAspLeuThrAlaGluGluLysGluThrVal-2273 2291-SerAlaThrAspAlaAlaGln-2297 2304-SerAlaValGluAsnAsnAspThrValGluGlnVal-2315 2319-LeuArgHisProArg-2323 2331-ValHisLysAspProGlySerThrLeu-2339 2379-IleThrArgGluPheGlyLys-2385 2393-AsnSerHisGluSerGlyGluLysIleAsnTyrSerIleArgArgAsnLeuSerLeuAspLysAlaAspGl uMetIleAsp-2419 2424-GluIleGlyArgGluIleAla-2430 2435-ArgLeuAsnThrLysGluLeu-2441 2456-GlnAlaGluArgAsnSerAsnGly-2463 2466-AspValValArgLysArgLeuSerGluLysAspTyrGlnAsn-2479 2496-IleGlnGlnArgArgLysGlnIleArg-2504 2510-ArgGlnTrpArgArg-2514 564-2 AMPHI Regions - AMPHI 6-TyrLysValValPhe-10 25-LysArgGluGlyLysAsnThr-31 40-LeuProAsnAspIleAlaGlyPheAlaGlyPheIleHisSerIleSer-55 118-AsnGlnTyrAlaGlnPhe-123 162-ValAsnGlnIleAsnSerSerHisSerSerGlnLeuAsn-174 244-AspTyrThrArgIleLeuSerTyrHisSer-253 288-AlaAlaAsnThrSerAsnAsnThrAla-296 311-LysLeuGlyGlyMetTyr-316 322-LeuIleSerThrValGluGln-328 390-SerGlnThrLeuAsp-394 407-ValArgAsnLeuGlyArgLeuLysAsnGlnAsn-417 433 -LeuAspAsnThrGlyAsnl1eThrGlnThrGly-443 449-LeuValSerAlaGlyLysPheAspAsnSer-458 478-IleProGlnIleProΞerThr-484 518-IleGlnThrThrGlyAlaPheAspAsnAlaGlySerIleAsnAla-532 561-SerPheAsnAsnThrValLys-567 600-LeuHisAsnAlaGly-604 638-GlyLeuHisAsnAlaGly-643 658-LeuArgAsnThrGlyLysVal-664 736-LeuTyrAsnGlnHisGly-741 765-AspGlyThrIleGlnSerAla-771 841-AspAsnGlnValThrGlyLys-847 871-AspGlyLeuThrHisIleGlyAlaGly-879 882-LeuThrAsnThrGlyThrGlyLysIleTyr-891 958-AlaGlyMetAlaAspThrPheVal-965 980-SerValArgAsnMetGlnAsnIleAsnAsnHis-990 1000-AlaGluLysGlnVal-1004 1125-ThrGlnTrpAspSerValThrLys-1132 1185-IleLysLeuIleAspGlyValSerThr-1193 1263-HisLysArgLeuGlyAspGlyTyr-1270 1278-GluGlnIleHisGlnLeuThrGlyTyrArgArgLeuAspGlyTyr-1292 1299-PheLysAlaLeuMe AspAsn-1305 1325-GlnValAlaArgLeu-1329 1461-ThrAlaIleAspArgMetAlaGlyIleAsnValValGlySerHisThrGluGlnValAspAsnArg-1482 1504-SerAsnGlnValLysAspGlyThrThr-1512 1515-ThrAlaGlyAsnAsn-1519 1542-ArgHisValArgGlnSerThrGluVal-1550 1596-ArgGlnIleThrGluLeu-1601 1720-IleIleGlySerLeuAsn-1725 1791-AlaGlnAsnPheIleGlnAlaAlaGlnAsnValGlyLysSer-1804 1822-TyrGlnAlaThrGlnGlnMet-1828 1870-GluAlaAlaAlaSerGln-1875 1925-GlySerGluGlnSer-1929 1955-GlyGlyAsnIleGlyLysGlyLys-1962 2106-AspIleGlnAsnHisSer-2111 2138-GlnGlyArgProThrAspArgIleSerProAla-2148 2177-AlaGlyGlnLeuAlaArgThrGlyArgThrAlaLys-2188 2204-AspGlnHisSerGlyHisLeuLysAsnSerPhe-2214 2228-GluValThrLysGluPheGlyArgAsnAlaAla-2238 2243-AlaValAlaAspLysLeuGlyAsnThrGlnSerTyrGluArgTyrGln-2258 2297-ArgTyrAspThrTrpLysGlu-2303 2308-ArgSerIleLeuHisGlyAlaAlaGly-2316 2320-ThrGlySerLeuGlyGlyIleLeuAla-2328 2336-AlaProTyrLeuAspLysAlaAlaGluAsnLeuGlyPro-2348 2352-AlaAlaValAsnAlaLeuGly-2358 2395-LysTyrAlaGluAlaLeuLysArg-2402 2404-ValGluLysArgGluGly-2409 2424-GlnIleLeuArgTrpValAspLysGlySerGlnAspGly-2436 2470-GlnThrTyrAsnAspProLysLeuPheGluGluTyr-2481 2520-GluGlyLeuThrSerLeuVal-2526 2537-LeuAlaGlyIleArgAsnLeuLysAsnIle-2546 2571-ValAlaLysGlyAspArg-2576 2620-LysProGlnArgGln-2624 2647-AspValCysThrGluCys-2652 2669-ProGluIleGluArg-2673 Antigenic Index - Jameson-Wolf 10-PheAsnLysHisArgAsnCysMet-17 22-GluAsnAlaLysArgGluGlyLysAsnThrAlaAsp-33 82-ValAlaAspLysSerAlaProAlaGlnGlnGln-92 125-ValGlyAsnArgGlyAlaIleLeuAsnAsnSerArgSerAsnThrGlnThr-141 150-AsnProTrpLeuAla-154 156-GlyGluAlaArgVal-160 165-IleAsnSerSerHisSerSerGlnLeuAsnGly-175 177-IleGluValGlyGlyArgArgAlaGluVal-186 203-AsnAlaSerArgAlaThrLeu-209 214-ProGlnTyrGlnAlaGlyAspLeuSerGlyPheLysIleArgGlnGlyAsn-230 237-GlyLeuAspAlaArgAspThrAspTyrThrArg-247 250-SerTyrHisSerLysIleAspAla-257 262-GlnAspValArgVal-266 269-GlyGlnAsnAspValAlaAlaThrGlyAspAlaHisSerPro-282 290-AsnThrSerAsnAsnThrAlaAsnAsnGlyThr-300 308-AspThrGlyLysLeuGlyGly-314 327-GluGlnAlaGlyIleArgAsnGlnGlyGln-336 347-AsnAlaGluGlyLysLeuValAsn-354 361-ThrGlyGluAsnHis-365 373-AsnValHisAsnSerGlyThrValAlaSerGlnAspAspAlaAsnIleHis-389 391-GlnThrLeuAspAsnSerGlyThrVal-399 401-SerSerGlyArgLeuThrVal-407 409-AsnLeuGlyArgLeuLysAsnGlnAsnAsnGly-419 424-AlaArgLeuAspMetSerThrGlyGlyLeuAspAsnThrGlyAsnIleThrGlnThrGlySerGln-445 453-GlyLysPheAspAsnSerGlyLysIleGlyValSerAspValProGlnThrGlyLeuAsnProAsnProSer Val-477 486-ThrGlySerGlySer-490 493-ValSerValSerLysProGlySerAsnAsnProValSerProThrAlaProAlaLysAsnTyrAla-514 525-AspAsnAlaGlySerIleAsnAlaGlyGlyGlnIleAsp-537 542-AsnGlyLeuGlyAsnSerGlySer-549 553-AlaLysLeuArgValSerGlyAspSerPheAsnAsnThrValLysGlyLysLeuGlnAla-572 580-GlnThrAlaLysAsnSerGlyHis-587 591-GlnThrGlyLysIleAspAsnArgGluLeuHisAsnAlaGlyGlu-605 615-HisSerGlyArgLeuSerAsnAspLysLysGlyAsnIle-627 647-AlaAspSerGlyThrValThrThrLysAsnAsnLeuArgAsnThrGlyLysValSerValAlaArgLeuAsn ThrGluGlyGlnThrLeuAspAsnThrArgGlyArgIleGluAlaGluThrValAsn-689 694-GlnLeuThrAsnGlnSerGlyHis-701 710-IleAsnSerArgAsnValAspAsnGlnAsnGlyLysLeuLeuSer-724 732-ValSerAspGlyLeuTyrAsnGlnHisGly-741 750-SerIleHisAspLysAsnGlnAsnThr-758 761-LeuAsnAsnAlaAspGlyThrIle-768 780-SerLeuAlaAsnAsnGlyThr-786 789-AlaGlyAsnLysLeuAsp-794 797-LeuThrAspAspPheValValGluArgAspLeuThrAlaGlyLys-811 817-IleLysGlyArgLeuLysAsnThrHisThr-826 836-AsnAlaGlyAsnIleAspAsnGlnVal-844 849-IleGlyGlyGluGlnThrAspIleThrSerGluGlnHisValAspAsnArgGlyLeuIleAsnSerAspGly -872 881-ThrLeuThrAsnThrGlyThrGlyLys11eTyr-891 903-LeuAsnArgGluGluThrThrGluGlySerThrLysAla-915 919-AlaAlaArgLysArgLeuAspIleGlyAlaLysGluIleHisAsnGlnGluGly-936 939-LeuSerSerGluGly-943 948-GlyAsnArgLeuAspGluGlnHisHis-956 985-GlnAsnIleAsnAsnHisPheLysThrGluThrTyrLeuAlaLysAlaGluLysGlnValArgAsp-1006 1017-GlnAlaGlyLysAspGlyLeuPheAspAsnSerGlnGlyGlnLysAspGlnThrThr-1035 1039-HisLeuLysAsnGlySerArgIleGluAla-1048 1060-ThrTyrLysGluArgIleIleGluAsnArgProAlaHis-1072 1076-GlyGlyAspLeuThrAlaSerGlyGlnAsnTrpLeuAsnLysAspSerArgIle-1093 1098-ArgIleIleThrAspAspLeuAsnGlnLysGluIleThrAsnGlnSerThrThrGlyLysGlyArgThrAs pAlaVal-1123 1126-GlnTrpAspSerValThrLysLysGlyTrpTyrSerGlyArgLysArgGlnArgArgThrGluArgAsnHi sThrProTyrHisAsp-1154 1160-HisAspPheAspThrProVal-1166 1172-AsnAlaAlaSerProSerPhe-1178 1196-ValAsnGlyGlnArgIleHisThr-1203 1223-ThrThrHisProAspAsnLysGlyTrp-1231 1234-GluThrAspProGlnPheAlaAspTyrArgArgTrpLeuGlySerAspTyr-1250 1258-AspThrAsnHisLeuHisLysArgLeuGlyAspGlyTyrTyrGluGlnLysLeuValAsn-1277 1285-GlyTyrArgArgLeuAspGlyTyrArgSerAspGluGluGlnPheLysAlaLeuMetAspAsnGly-1306 1343-LeuSerAspGlySerThrGln-1349 1359-LeuAlaArgLysGlyAspLeuAsnThrSerGlyGly-1370 1382-GlnAsnGlyAsnLeuThrAsn-1388 1403-ArgAsnlleAsnSerAsnGlyAsnlleGln-1412 1416-IleGlyLeuLysAlaGluLysSerIleAsnIleAspGlyGlyGlnValGln-1432 1445-AsnLeuAsnGlyThrThrGlnThrSerGlyAsnGluArgAsnGlyAsnThrAlaIleAspArgMetAla-l 467 1473-GlySerHisThrGluGlnValAspAsnArgThrSerAspGly-1486 1491-HisAlaSerAsnAspIle-1496 1503-ValSerAsnGlnValLysAspGlyThrThr-1512 1525-IleArgThrGluHisArgGluAlaTyrGlyThrLeuAspAspGluAsnHisArgHisValArgGlnSerTh rGluValGlySerSerIleArgThrGlnAsnGly-1559 1564-AlaGlyAsnAspLeuLysIleArgGlnGlyGluLeuGluAlaGluGluGlyLysThr-1582 1586-AlaGlyArgAspValThrIleSerGluGlyArgGlnIleThrGluLeuAspThrSerValSerGlyLysSe rLysGlyIleLeuSerSerThrLysThrHisAspArgTyrArgPheSerHisAspGluAlaVal-1630 1633-AsnIleGlyGlyGlyLysMet-1639 1644-GlyGlnAspIleAsnValArgGlySerAsnLeuIleSerAspLysGlyIleVal-1661 1664-AlaGlyHisAspIleAspIleSerThrAlaHisAsnArgTyrThrGlyAsnGluTyrHisGluSerLysLy sSerGlyVal-1690 1699-Thr11eGlyAsnArgLysThrThrAspAspThrAspArgThrAsnl1e-1714 1723-SerLeuAsnGlyAspThr-1728 1732-AlaGlyAsnArgTyrArgGlnThrGlySerThrValSerSerProGluGlyArgAsnThrValThr-1753 1761-PheAlaAsnAsnArgTyrAlaThrAspTyrAlaHisThrGlnGluGlnLysGly-1778 1799-GlnAsnValGlyLysSerLysAsnLysArgValAsn-1810 1832-AlaProSerSerSerAlaGlyGlnGlyGlnAsnAsnAsnGlnSerProSerIle-1849 1854-ThrTyrGlyGluGlnLysSerArgAsnGluGlnLysArgHisTyrThr-1869 1878-GlyLysGlyGlnThr-1882 1886-AlaThrGlySerGlyGluGlnSerAsnlleAsn-1896 1898-ThrGlySerAspVal-1902 1919-GlnSerAlaLysGlnAspGlySerGluGlnSerLysAsnLysSerSerGlyTrpAsnAla-1938 1954-AlaGlyGlyAsnIleGlyLysGlyLysGluGlnGlyGlySerThrThrHisArgHisThrHisValGlySe rThrThrGlyLysThrThrIleArgSerGlyGlyAspThrThrLeu-1992 1999-GlyLysGlyIleGlnAlaAspThrArgAsnLeuHis-2010 2013-SerValGlnAspThrGluThrTyrGlnSerLysGlnGlnAsnGlyAsn-2028 2038-SerAlaSerGlySerTyrArgGlnΞerLysValLysAlaAspHis-2052 2062-TyrAlaGlyGluAspGlyTyrGlnIleLysValArgAspAsnThrAspLeuLysGly-2080 2086-SerGlnSerAlaGluAspLysGlyLysAsnLeuPhe-2097 2105-SerAspIleGlnAsnHisSerArgTyrGluGlyArgSerPheGly-2119 2126-LeuAsnGlyGlyTrpAspGlyThrValThrAspLysGlnGlyArgProThrAspArgIleSerPro-2147 2151-TyrGlySerAspGlyAspSerLysAsnSerThrThrArgSerGlyValAsnThrHis-2169 2173-IleThrAspGluAlaGlyGlnLeuAlaArgThrGlyArgThrAlaLysGluThrGluAlaArgIle-2194 2197-GlyIleAspThrGluThrAlaAspGlnHisSerGlyHisLeuLysAsnSerPheAspLysAspAlaValAl aLysGluIleAsnLeuGlnArgGluValThrLysGluPheGlyArgAsnAlaAla-2238 2244-ValAlaAspLysLeuGlyAsnThrGlnSerTyrGluArgTyrGlnGluAlaArgThrLeuLeu-2264 2266-AlaGluLeuGlnAsnThrAspSerGluAlaGluLysAlaAlaPhe-2280 2292-AlaGluAsnGlnSerArgTyrAspThrTrpLysGluGlyGlyIleGlyArgSerIle-2310 2338-TyrLeuAspLysAlaAlaGluAsnLeuGlyProAlaGly-2350 2378-ValAspTrpAsnAsnArgGlnLeuHisProLysGluMetAlaLeu-2392 2394-AspLysTyrAlaGluAlaLeuLysArgGluValGluLysArgGluGlyArgLysIleSerSerGlnGluAl aAlaMetArgIleArgArgGlnIle-2425 2428-TrpValAspLysGlySerGlnAspGlyTyrThrAspGlnSerVal-2442 2448-MetLysGlyGluAspLysAlaLeu-2455 2460-AspTyrArgAspTyrGlyAlaArgAsnProGlnThrTyrAsnAspProLysLeuPheGluGluTyrArgAr gGlnAspLysProGluTyrArgAsn-2491 2496-HisSerGlyThrLysAspThrLysIleArgGlnGlyGluArgLysAsnGluGluPhe-2514 2527-AsnProAsnProArgIleLysVal-2534 2541-ArgAsnLeuLysAsnIleLysProThrValThrGlySerAspPro-2555 2569-GlyAsnValAlaLysGlyAspArgIleProAspThrAlaLeuAlaSerLysGlyIleLysHisLysAsnAr gLysAspGlnLeuGluLysAsnLysLysSerGlyGluAspPheGluMet-2608 2610-IleTyrGlnLysLysValLysGlnGlyPheLysProGlnArgGlnIleThrValLysThrLysSerGlyVa lLysThrArgLeuAspIleIleSerLysGluGlyGlyLeuAspValCysThrGluCysLysAla-2654 2659-ProLeuThrLysAsnGlnLysLysAlaPheProGluIleGluArgThrGlyAla-2676 2680-GlyLysGlyLysProGlyTyrProLysGlyThrLysIleGluProThrLysValIleIleGluArgLysAr g-2703 Hydrophilic Regions - Hopp-Woods 10-PheAsnLysHisArgAsn-15 22-GluAsnAlaLysArgGluGlyLysAsnThrAlaAsp-33 82-ValAlaAspLysSerAlaPro-88 134-AsnSerArgSerAsnThr-139 156-GlyGluAlaArgVal-160 179-ValGlyGlyArgArgAlaGluVal-186 222-SerGlyPheLysIleArgGln-228 238-LeuAspAlaArgAspThrAspTyr-245 271-AsnAspValAlaAla-275 329-AlaGlyIleArgAsn-333 348-AlaGluGlyLysLeu-352 361-ThrGlyGluAsnHis-365 381-AlaSerGlnAspAspAlaAsnIle-388 409-AsnLeuGlyArgLeuLysAsnGlnAsn-417 424-AlaArgLeuAspMet-428 453-GlyLysPheAspAsnSerGlyLysIleGlyVal-463 494-SerValSerLysProGlySer-500 553-AlaLysLeuArgValSerGly-559 566-ValLysGlyLysLeuGlnAla-572 580-GlnThrAlaLysAsnSer-585 593-GlyLysIleAspAsnArgGluLeuHisAsn-602 618-ArgLeuSerAsnAspLysLysGlyAsnIle-627 650-GlyThrValThrThr-654 656-AsnAsnLeuArgAsnThrGlyLys-663 669-LeuAsnThrGluGlyGlnThrLeuAspAsnThrArgGlyArgIleGluAlaGluThr-687 713-ArgAsnValAspAsnGlnAsn-719 750-SerIleHisAspLysAsnGlnAsn-757 763-AsnAlaAspGlyThrIle-768 801-PheValValGluArgAspLeuThrAla-809 817-IleLysGlyArgLeuLysAsn-823 852-GluGlnThrAspIleThrSer-858 860-GlnHisValAspAsnArgGlyLeuIle-868 903-LeuAsnArgGluGluThrThrGluGlySerThrLysAla-915 919-AlaAlaArgLysArgLeuAspIleGlyAlaLysGluIleHisAsnGlnGlu-935 949-AsnArgLeuAspGluGlnHisHis-956 995-ThrTyrLeuAlaLysAlaGluLysGlnValArgAsp-1006 1018-AlaGlyLysAspGlyLeuPhe-1024 1027-SerGlnGlyGlnLysAspGlnThr-1034 1042-AsnGlySerArgIleGluAla-1048 1060-ThrTyrLysGluArgIleIleGluAsnArgPro-1070 1087-LeuAsnLysAspSerArgIle-1093 1099-IleIleThrAspAspLeuAsnGlnLysGluIleThrAsn-llll 1114-ThrThrGlyLysGlyArgThrAspAlaVal-1123 1134-GlyTrpTyrSerGlyArgLysArgGlnArgArgThrGluArgAsnHis-1149 1235-ThrAspProGlnPheAlaAspTyrArgArg-1244 1261-HisLeuHisLysArgLeuGly-1267 1287-ArgArgLeuAspGlyTyrArgSerAspGluGluGlnPheLysAlaLeuMet-1303 1360-AlaArgLysGlyAspLeuAsnThr-1367 1416-IleGlyLeuLysAlaGluLysSerIleAsn-1425 1453-ΞerGlyAsnGluArgAsnGlyAsnThrAlaIleAspArgMetAla-1467 1475-HisThrGluGlnValAspAsnArgThrSerAsp-1485 1505-AsnGlnValLysAspGlyThrThr-1512 1525-IleArgThrGluHisArgGluAlaTyrGlyThrLeuAspAspGluAsnHisArgHisValArgGlnSerTh rGluVal-1550 1554-IleArgThrGlnAsn-1558 1564-AlaGlyAsnAspLeuLysIleArgGlnGlyGluLeuGluAlaGluGluGlyLysThr-1582 1586-AlaGlyArgAspValThrIleSerGluGlyArgGlnIleThrGluLeuAspThr-1603 1605-ValSerGlyLysSerLysGlyIle-1612 1616-ThrLysThrHisAspArgTyrArgPheSerHisAspGluAlaVal-1630 1647-IleAsnValArgGly-1651 1653-AsnLeuIleSerAspLysGlyIleVal-1661 1664-AlaGlyHisAspIleAspIle-1670 1681-GluTyrHisGluSerLysLysSerGlyVal-1690 1701-GlyAsnArgLysThrThr spAspThrAspArgThrAsn-1713 1734-AsnArgTyrArgGlnThrGly-1740 1744-SerSerProGluGlyArgAsnThrValThr-1753 1774-GlnGluGlnLysGly-1778 1800-AsnValGlyLysSerLysAsnLysArgValAsn-1810 1836-SerAlaGlyGlnGlyGlnAsnAsnAsnGln-1845 1856-GlyGluGlnLysSerArgAsnGluGlnLysArgHisTyrThr-1869 1888-GlySerGlyGluGlnSerAsn-1894 1919-GlnSerAlaLysGlnAspGlyΞerGluGlnSerLysAsnLysSerSer-1934 1957-AsnIleGlyLysGlyLysGluGlnGlyGly-1966 1982-ThrThrIleArgSerGlyGlyAspThrThrLeu-1992 2002-IleGlnAlaAspThrArgAsnLeuHis-2010 2013-SerValGlnAspThrGluThrTyrGlnSerLysGlnGlnAsn-2026 2041-GlySerTyrArgGlnSerLysValLysAlaAspHis-2052 2063-AlaGlyGluAspGlyTyrGlnIleLysValArgAspAsnThrAspLeuLysGly-2080 2087-GlnSerAlaGluAspLysGlyLysAsn-2095 2111-SerArgTyrGluGlyArgSer-2117 2133-ThrValThrAspLysGlnGlyArgProThrAspArgIleSerPro-2147 2152-GlySerAspGlyAspSerLysAsnSerThrThrArgΞerGlyVal-2166 2173-IleThrAspGluAlaGlyGln-2179 2181-AlaArgThrGlyArgThrAlaLysGluThrGluAlaArgIle-2194 2198-IleAspThrGluThrAlaAspGlnHisSerGlyHisLeu-2210 2212-AsnSerPheAspLysAspAlaValAlaLysGluIleAsnLeuGlnArgGluValThrLysGluPheGlyAr g-2235 2244-ValAlaAspLysLeuGlyAsn-2250 2252-GlnSerTyrGluArgTyrGlnGluAlaArgThrLeuLeu-2264 2266-AlaGluLeuGlnAsnThrAspSerGluAlaGluLysAlaAlaPhe-2280 2294-AsnGlnSerArgTyrAspThrTrpLysGluGlyGlyIle-2306 2338-TyrLeuAspLysAlaAlaGluAsnLeuGlyProAlaGly-2350 2384-GlnLeuHisProLysGluMetAlaLeu-2392 2394-AspLysTyrAlaGluAlaLeuLysArgGluValGluLysArgGluGlyArgLysIleSerSerGlnGluAl aAlaMetArgIleArgArgGlnIle-2425 2428-TrpValAspLysGlySerGlnAspGlyTyrThr-2438 2448-MetLysGlyGluAspLysAlaLeu-2455 2460-AspTyrArgAspTyrGlyAlaArgAsnProGlnThrTyrAsnAsp-2474 2476-LysLeuPheGluGluTyrArgArgGlnAspLysProGluTyrArg-2490 2498-GlyThrLysAspThrLysIleArgGlnGlyGluArgLysAsnGluGluPhe-2514 2528-ProAsnProArgIleLys-2533 2541-ArgAsnLeuLysAsnl1eLys-2547 2570-AsnValAlaLysGlyAspArgIleProAsp-2579 2585-LysGlyIleLysHisLysAsnArgLysAspGlnLeuGluLysAsnLysLysSerGlyGluAspPheGluMe t-2608 2610-IleTyrGlnLysLysValLysGlnGlyPheLysProGlnArg-2623 2625-IleThrValLysThrLysSerGlyValLysThrArgLeuAspIleIleSerLysGluGlyGlyLeu-2646 2648-ValCysThrGluCysLysAla-2654 2660-LeuThrLysAsnGlnLysLysAlaPheProGluIleGluArgThrGly-2675 2680-GlyLysGlyLysProGlyTyrProLysGlyThrLysIleGluProThrLysValIleIleGluArgLysAr g-2703 565 AMPHI Regions - AMPHI 50-AlaThrCysThrArgAlaMetSerLysSer-59 66-SerSerTrpAlaArg-70 84-IleSerThrTrpSerAspLeu-90 103 -AspPheMetSerGlnLeuAspLeuThr-111 140-SerHisSerGlyGluThrIleSerSerCysProAlaMetAlaSerIleThrLysProAsn-159 184-AlaAsnThrThrSerAlaPhe-190 Antigenic Index - Jameson-Wolf 1-MetAspSerThrLeuSerLysThrCys-9 23-PheAlaArgProArgProAlaAlaSerAsnThrSerLeu-35 37-PheAlaSerProAsnAspThrGlySer-45 55-AlaMetSerLysSerSerAlaLysTyrGly-64 67-SerTrpAlaArgThrArgProThrValCysProProLeuProLysProThrIle-84 99-CysArgSerSerAspPheMetSer-106 109-AspLeuThrLysArgProThrSerAlaSerLeuProProLysArgLysGlyAlaIle-127 129-IleAspSerArgThrAlaAla-135 140-SerHisSerGlyGluThrIleSerSer-148 154-SerIleThrLysProAsnSerProProCysAlaArgTyr-166 170-LeuArgLeuSerProThrGlu-176 194-SerIleAlaAsnSerIleAsnThrCysArgGlnProPro-206 Hydrophilic Regions - Hopp-Woods 24-AlaArgProArgProAlaAla-30 39-SerProAsnAspThrGlySer-45 55-AlaMetSerLysSerSerAla-61 69-AlaArgThrArgPro-73 100-ArgSerSerAspPhe-104 109-AspLeuThrLysArgProThrSer-116 119-LeuProProLysArgLysGlyAlaIle-127 129-IleAspSerArgThr-133 141-HisSerGlyGluThrIleSer-147 156-ThrLysProAsnSer-160 566 Hydrophilic Regions - Hopp-Woods 29-ProPheArgAspGlyAlaHisLysMet-37 64-AsnIleProAspArgProAla-70 95-ValAlaLysArgGluLeuPhe-101 116-IleGlyIleAspArgAsnAsnArgArgGluAlaAsnGluGlnLeuIle-131 134-GlyLeuValArgLysAsnGlu-140 149-GluGlyThrArgLeuAlaProGlyLysArgGlyLysTyrLysLeuGlyGly-165 211-SerGlySerGluAlaGluLeuMetGluLysCysGluHisLeuIle-225 242-MetProSerGluThrAla-247 Antigenic Index - Jameson-Wolf 32-PheAlaValAspProAsnCysGlyAlaAspGlyThrGlyGlyLysGlyHisAla-49 61-AlaValGlyGlyGluGluGlyGlyValValAlaAspAspValAlaCysAlaAspGlyGlyLysAlaAspGlyA rgArgIleAlaArg-89 105-SerAlaGluArgAlaGlyAspAspPheAla-114 Hydrophilic Regions - Hopp-Woods 36-ProAsnCysGlyAlaAspGlyThrGlyGlyLysGlyHisAla-49 63-GlyGlyGluGluGlyGlyValValAlaAspAspValAlaCys-76 78-AspGlyGlyLysAlaAspGlyArgArgIleAlaArg-89 105-SerAlaGluArgAlaGlyAspAspPheAla-114 567 AMPHI Regions - AMPHI 60-GlyValTyrGlnVal-64 98-GluLeuValGlnGluIleAlaArgGluVal-107 112-AlaLeuLysAlaVal-116 154-TyrAlaLeuGluGlyIleSerAspLeuIleAlaThrValArgLysIleArgGln-171 180-ThrGlyIleValArg-184 195-AlaGluValSerGluGlnLeuArgSerHisPheGlyAspLeuLeu-209 Antigenic Index - Jameson-Wolf 10-AsnGlnLysGlyGlyValGlyLysThrThrThr-20 28-LeuAlaSerArgGlyLysArg-34 38-ValAspLeuAspProGlnGlyAsnAlaThrThrGlySerGlyIleAspLysAlaGlyLeuGlnSerGly-60 67-GlyAspAlaAspValGln-72 75-AlaValArgSerLysGluGlyGly-82 95-AlaGluIleGluLeu-99 101-GlnGluIleAlaArgGluValArgLeuLysAsnAlaLeuLysAlaValGluGluAspTyrAsp-121 127-CysProProSerLeu-131 164-AlaThrValArgLysIleArgGlnAlaValAsnProAspLeuAspIle-179 185-ThrMetTyrAspSerArgSerArgLeuValAlaGluValSerGluGlnLeuArgSerHisPheGlyAspLeu -208 214-IleProArgAsnIleArgLeuAlaGluAlaProSerHisGly-227 235-AlaGlnAlaLysGlyThrLys-241 248-AspGluLeuAlaAlaArgValSerGlyLys-257 Hydrophilic Regions - Hopp-Woods 10-AsnGlnLysGlyGlyValGlyLys-17 28-LeuAlaSerArgGlyLysArg-34 40-LeuAspProGlnGly-44 50-SerGlyIleAspLysAlaGlyLeu-57 67-GlyAspAlaAspValGln-72 75-AlaValArgSerLysGluGlyGly-82 95-AlaGluIleGluLeu-99 lOl-GlnGluIleAlaArgGluValArgLeuLysAsnAlaLeuLysAlaValGluGluAspTyrAsp-121 164-AlaThrValArgLysIleArgGln-171 175-ProAspLeuAspIle-179 186-MetTyrAspSerArgSerArgLeuValAlaGluValSerGluGlnLeuArg-202 216-ArgAsnIleArgLeuAlaGluAlaProSer-225 235-AlaGlnAlaLysGlyThrLys-241 248-AspGluLeuAlaAla-252 568 AMPHI Regions - AMPHI 32-AsnIlePheArgArgIle-37 49-LysAlaCysLysAsn-53 71-GluLysAlaAsnThrValArgTyr-78 82-SerLeuAlaGlnCysPheThr-88 112-ArgProLeuProSerIleIleThrAla-120 169-GluPheValGlyPheGlyAsnValPheValGlyGlnPheLeuAsnArgPhePhe-186 200-GluGluPhePheAspValValVal-207 228-PheAsnGlnValPheAlaAlaPheLeu-236 241-HisArgHisAlaAspGlnValAlaAspSerCysArgValGlnSerGln-256 Antigenic Index - Jameson-Wolf 14-SerAlaSerSerMetProCysArgIleCysArgLeuLysArgSerArgLeuProAsnIlePhe-34 39-PheSerCysArgArgArgThrCysPheCysLysAlaCysLysAsnSerProIleArgAsnGluThrSerSerS erGlyArgArgGlnPheSerValGluLysAlaAsnThr-75 91-SerAsnAlaSerLysProArgLeu-98 100-ProIleMetArgGlyArgLysArgPhePheAla-llO 141-PheArgGlySerAlaPheLysCysArgLeuAsnAlaGluProCysArg-156 213-ValAlaAspArgAspAlaAla-219 237-GlyGlnHisGlyHisArgHisAlaAspGlnValAlaAspSerCysArgValGlnSerGln-256 Hydrophilic Regions - Hopp-Woods 21-ArgIleCysArgLeuLysArgSerArgLeu-30 41-CysArgArgArgThrCysPhe-47 49-LysAlaCysLysAsnSerProIleArgAsnGluThrSerSerSerGlyArgArgGlnPheSerValGluLysA laAsnThr-75 93-AlaSerLysProArgLeu-98 102-MetArgGlyArgLysArgPhePheAla-llO 144-SerAlaPheLysCysArgLeuAsnAlaGluProCysArg-156 213-ValAlaAspArgAspAlaAla-219 239HisGlyHisArgHisAlaAspGlnValAlaAspSerCysArgVal-253 569 AMPHI Regions - AMPHI 29-AlaAlaPheCysGlyLeuIleAlaLeuIleAlaLeuTrpGluTyrAlaArgMetGlyGlyLeuCysLys-51 86-PheTrpLeuAlaValMetPro-92 166-SerProGlyLysSerTrpGluGlyAlaIle-175 203-ThrValLeuIleGlyLeu-208 210-LeuThrValValSerValCysGlyAspLeuLeuGluSerTrpLeuLys-225 229-GlyIleLysAspSerSer-234 Antigenic Index - Jameson-Wolf 50-CysLysIleLysThrAsnHis-56 98-LysTrpArgLeuAsnGlyGlyTrp-105 124-SerLeuArgProHisProAspAspAlaLeu-133 154-LysAlaPheGlyLysHisLysIle-161 165-IleSerProGlyLysSerTrpGlu-172 227-AlaAlaGlyIleLysAspSerSerLysLeuLeuProGlyHis-240 242-GlyValPheAspArgThrAspSer-249 Hydrophilic Regions - Hopp-Woods 50-CysLysIleLysThr-54 127-ProHisProAspAspAlaLeu-133 155-AlaPheGlyLysHisLysIle-161 227-AlaAlaGlyIleLysAspSerSerLys-235 243-ValPheAspArgThrAspSer-249 570 AMPHI Regions - AMPHI 6-ArgAlaPheAlaAlaAlaLeuIleGlyLeu-15 22-HisAlaAspThrPheGlnLysIleGlyPheIleAsn-33 43-GlnAlaArgLysIleGlnLysThrLeuAspSer-53 60-AspGluLeuGlnLysLeuGln-66 81-LeuArgAsnAlaLysLys-86 91-GluLysTrpArgGlyLeuValAla-98 122-LeuGlnGlnAsnAlaAsnArgValIleValLysIle-133 Antigenic Index - Jameson-Wolf 33-AsnThrGluArgIleTyrLeuGluSerLysGlnAlaArgLysIleGlnLysThrLeuAspSerGluPheSerA laArgGlnAspGluLeuGlnLysLeuGlnArgGluGlyLeuAspLeuGluArgGlnLeuAlaGluGlyLysLeuAr gAsnAlaLysLysAlaGlnAlaGluGluLysTrpArg-94 lOO-PheArgLysLysGlnAlaGlnPheGluGluAspTyrAsnLeuArgArgAsnGluGluPheAla-120 123-GlnGlnAsnAlaAsnArgVal-129 133-IleAlaLysGlnGluGlyTyrAspVal-141 152-GlnTyrAspValThrAspSerValIleLysGluMetAsnAlaArg-166 Hydrophilic Regions - Hopp-Woods 37-IleTyrLeuGluSerLysGlnAlaArgLysIleGlnLysThrLeuAspSerGluPheSerAlaArgGlnAspG luLeuGlnLysLeuGlnArgGluGlyLeuAspLeuGluArgGlnLeuAlaGluGlyLysLeuArgAsnAlaLysLy sAlaGlnAlaGluGluLysTrpArg-94 100-PheArgLysLysGlnAlaGlnPheGluGluAspTyrAsnLeuArgArgAsnGluGluPheAla-120 133-IleAlaLysGlnGluGlyTyr-139 154-AspValThrAspSerValIleLysGluMetAsnAlaArg-166 571 AMPHI Regions - AMPHI 6-AlaValAsnValLeu-10 40-AspGlyAlaArgValPheArgAlaGly-48 63-AlaAlaValAlaAspPhePheAlaVal-71 94-ValGluValPheLysGlu-99 Antigenic Index - Jameson-Wolf 13-AlaAlaGlyArgGlyThr-18 35-LysGlnAlaGlnAlaAspGlyAlaArgValPheArgAlaGlyHisArgGluGluGlnLeuGlyGlyAspVal- 58 76-PheArgThrGluArgAlaAla-82 96-ValPheLysGluGlyAspPhe-102 110-ArgAsnAlaAspPheAlaAlaGluHisGlnArGluGlyPheAlaGlnGlyGluGluProGlyLeu-131 142-AlaAlaArgGlnGlyAspPheGlyVal-150 155-ValAlaAlaArgArgPro-160 Hydrophilic Regions - Hopp-Woods 13-AlaAlaGlyArgGly-17 35-LysGlnAlaGlnAlaAspGlyAlaArgValPheArgAlaGlyHisArgGluGluGlnLeuGly-55 76-PheArgThrGluArgAlaAla-82 96-ValPheLysGluGlyAspPhe-102 110-ArgAsnAlaAspPheAlaAlaGluHisGlnArgGluGlyPheAlaGlnGlyGluGluProGly-130 155-ValAlaAlaArgArgPro-160 572-2 AMPHI Regions - AMPHI 20-LeuAspValValSerArgHisProGluLysPheArgVal-32 39-LysGlnValGluLysLeuAlaAlaGlnCys-48 85-GlnAlaLeuValAspValAlaSerAlaAspGlu-95 101-CysAlaIleValGlyAlaValGlyLeuProSerAlaLeuAla-114 160-GlnValLeuProArgAspTyrAlaGlyArg-169 192-LeuAsnThrPheAspArgIleThrProAlaGlnAlaValLys-205 225-LysGlyLeuGluLeu-229 253-IleHisSerMetValArg-258 282-GlyLeuProGluArgIleAspSerGly-290 299-LeuSerAlaLeuThr-303 340-ValAlaAlaPheLeu-344 350-PheThrAspIleAlaLysThrValAlaHisCysLeuAlaGlnAspPheSerAspGlyIleGlyAspIleGly Gly-374 Antigenic Index - Jameson-Wolf H-SerThrGlySerIleGlyGluSerThrLeu-20 22-ValValSerArgHisProGluLysPheArg-31 39-LysGlnValGluLysLeuAla-45 59-AlaAspAlaGluHisAlaAlaArgLeu-67 69-AlaLeuLeuLysArgAspGlyThrAla-77 91-AlaSerAlaAspGluValSer-97 117-GlnLysGlyLysThr-121 125-AlaAsnLysGluThrLeu-130 140-ThrAlaArgAlaAsnGly-145 150-ProValAspSerGluHis-155 162-LeuProArgAspTyrAlaGlyArgLeuAsnGluHisGly-174 193-AsnThrPheAspArgIleThrProAlaGlnAlaValLysHisProAsnTrpArgMetGlyArgLysIleSer ValAspSer-219 224-AsnLysGlyLeuGluLeu-229 237-AsnCysProProAspLysLeuGluVal-245 257-ValArgTyrArgAspGlySerVal-264 269-GlyAsnProAspMetArgThr-275 283-LeuProGluArglleAspSerGlyValGlyAspLeuAspPhe-296 303-ThrPheGlnLysProAspPheAspArg-311 363-GlnAspPheSerAspGlyIleGlyAspIleGly-373 378-GlnAspAlaArgThrArgAlaGlnAla-386 Hydrophilic Regions - Hopp-Woods 22-ValValSerArgHisProGluLysPheArg-31 39-LysGlnValGluLysLeuAla-45 59-AlaAspAlaGluHisAlaAlaArgLeu-67 69-AlaLeuLeuLysArgAspGlyThrAla-77 91-AlaSerAlaAspGluValSer-97 126-AsnLysGluThrLeu-130 140-ThrAlaArgAlaAsnGly-145 151-ValAspSerGluHis-155 165-AspTyrAlaGlyArgLeuAsnGlu-172 196-AspArgIleThrPro-200 210-ArgMetGlyArgLysIleSerVal-217 225-LysGlyLeuGluLeu-229 239-ProProAspLysLeuGlu-244 257-ValArgTyrArgAspGlySer-263 269-GlyAsnProAspMetArgThr-275 283-LeuProGluArgIleAspSerGlyValGlyAspLeuAspPhe-296 305-GlnLysProAspPheAspArg-311 364-AspPheSerAspGlyIleGly-370 378-GlnAspAlaArgThrArgAlaGlnAla-386 574 AMPHI Regions - AMPHI 6-ProAsnSerLeuLysLys-ll 47-LeuLysGlnAlaLysSerIleProSerGlyPheTyrLysSerLeuAspAlaLeuValAspArgAsnSerGlyA rgAlaAlaArgGluLeuAlaGluValValAsp-81 94-GlyLysLeuTyrArgGln-99 113-MetLeuAspSerProAspThr-119 175-GluLysAlaValGluThrAlaArgLeu-183 218-AsnValGlyLysAlaLeuGluAlaAsnLysLysCys-229 246-PheProAlaAlaValGluAlaTyrAlaAlaIleGlu-257 266-MetValGlyGluLysLeuTyrGluAlaTyrAla-276 281-ProGluGluGlyLeuAsnArgLeuThrGlyTyrMetGlnThrPheProGluLeuAspLeu-300 332-AsnGlyValTyrArg-336 357-ArgSerValIleGlyArgGlnLeuGlnArgSer-367 Antigenic Index - Jameson-Wolf l-MetArgProAsnLeuProAsnSerLeuLysLysAlaAspMetAspAsn-16 45-ThrValLeuLysGlnAlaLysSerIleProSerGlyPheTyrLysSerLeuAspAlaLeuValAspArgAsnS erGlyArgAlaAlaArgGluLeuAlaGluValValAspGlyArgProGlnSerTyrAsp-88 96-LeuTyrArgGlnArgGlyGluAsnAspLysAlaIleAsnIleHisArgThrMetLeuAspSerProAspThrV alGlyGluLysArgAlaArgVal-127 135-TyrGlnSerAlaGlyLeuValAspArgAlaGlu-145 151-LeuGlnAspGlyLysMetAlaArgGluAlaArgGln-162 168-TyrGlnGlnAspArgAspTrpGluLysAlaValGluThr-180 182-ArgLeuLeuSerHisAspAspGlnThrTyr-191 221-LysAlaLeuGluAlaAsnLysLysCysThrArg-231 238-AspIleGluHisArgGlnGlyAsn-245 277-AlaGlnGlyLysProGluGluGlyLeuAsnArgLeuThrGlyTyr-291 312-LysCysGluLysGluAlaAla-318 323-GluLeuValArgArgLysProAspLeuAsnGly-333 341-LysLeuSerAspMetAsnProAlaTrpLysAlaAspAlaAspMetMetArg-357 368-ValMetTyrArgCysArgAsnCysHisPheLys-378 386-CysProAlaCysAsnLysTrpGlnThrPheThrProAsnLysIleGluVal-402 Hydrophilic Regions - Hopp-Woods 1-MetArgProAsnLeu-5 7-AsnSerLeuLysLysAlaAspMetAspAsn-16 45-ThrValLeuLysGlnAlaLysSerIle-53 62-AspAlaLeuValAspArgAsnSerGlyArgAlaAlaArgGluLeuAlaGluValValAspGlyArgProGlnS er-86 96-LeuTyrArgGlnArgGlyGluAsnAspLysAlaIleAsn-108 112-ThrMetLeuAspSerProAspThrValGlyGluLysArgAlaArgVal-127 140-LeuValAspArgAlaGlu-145 152-GlnAspGlyLysMetAlaArgGluAlaArgGln-162 169-GlnGlnAspArgAspTrpGluLysAlaValGluThr-180 184-LeuSerHisAspAspGlnThrTyr-191 221-LysAlaLeuGluAlaAsnLysLysCysThrArg-231 238-AspIleGluHisArgGlnGlyAsn-245 279-Gly ysProGluGluGlyLeuAsn-286 312-LysCysGluLysGluAlaAla-318 323-GluLeuValArgArgLysProAspLeu-331 349-TrpLysAlaAspAlaAspMetMetArg-357 368-ValMetTyrArgCysArgAsnCysHis-376 398-AsnLysIleGluVal-402 575 AMPHI Regions - AMPHI 8-PheArgLysProAlaSer-13 20-PheAlaGluAlaVa1-24 42-SerThrValSerGlyLeuPheSerAla-50 114-LeuSerLysSerLysSer-119 139-SerSerAspSerPro-143 150-PheThrSerPhePheGly-155 163-ValSerThrSerAlaLysValIleSerMetPro-173 217-SerLysValTyrGluProProAsnArgProSerAsn-228 237-AlaGluThrCysSerThr-242 287-AlaGlyPheSerAlaPheAlaSerGlyAla-296 298-ThrPheAlaSerGlyPheSerThrGly-306 308-SerThrValAlaCys-312 315-GlySerAspGlyMetAspAlaValSerAlaLeu-325 Antigenic Index - Jameson-Wolf 2-ValSerGlyGluGluAlaPheArgLysProAlaSerProGluGlyGluAlaGlyPhe-20 34-GlyArgLeuSerGluLysSerValSer-42 54-ThrAspSerGlySerGlyVal-60 96-SerSerSerCysValSerAlaProAspLysMetProPhe-108 113-ArgLeuSerLysSerLysSerMetArgLeuGluGly-124 134-PheAlaAspAsnSerSerSerAspSerProSerLysAlaSerVal-148 155-GlyAlaGlySerGly-159 173-ProSerSerAlaAlaSerSerArgSerGlySerSerSerGlyThrAspSerSerValArgArgAlaArgLeu AspTrpAlaArgArgLysSerSerSerArgAlaIle-208 211-AlaProProProAlaSer-216 218-LysValTyrGluProProAsnArgProSerAsnSer-229 232-SerValSerSerSerAlaGluThrCysSerThrGlySerGluThr-246 265-GlyAlaAspSerAlaAlaVal-271 280-GlyThrGlySerGlyArgThrAla-287 303 -PheSerThrGlyPhe-307 313-LeuAspGlySerAspGlyMetAsp-320 Hydrophilic Regions - Hopp-Woods 2-ValSerGlyGluGluAlaPheArgLysProAlaSerProGluGlyGluAlaGlyPhe-20 34-GlyArgLeuSerGluLysSerValSer-42 101-SerAlaProAspLysMetPro-107 113-ArgLeuSerLysSerLysSerMetArgLeuGluGly-124 137-AsnSerSerSerAspSerProSerLysAla-146 176-AlaAlaSerSerArgSerGlySerSerSerGlyThrAspSerSerValArgArgAlaArgLeuAspTrpAla ArgArgLysSerSerSerArgAlaIle-208 218-LysValTyrGluProProAsnArgProSerAsn-228 235-SerSerAlaGluThrCysSerThrGlySerGluThr-246 314-AspGlySerAspGlyMetAsp-320 576-1 AMPHI Regions - AMPHI 31-AlaSerGluProAlaAlaAla-37 46-SerIleGlySerThr-50 63-GlyArgSerLeuLysGlnMetLys-70 82-ThrGluAlaMetGln-86 102-GlnGluValMetMetLysPheLeuGlnGluGlnGlnAlaLysAlaValGluLysHis-120 140-AlaLysAspGlyValLysThrThr-147 199-SerGlnValIleProGlyTrpThrGluGlyVal-209 Antigenic Index - Jameson-Wolf 20-AlaCysGlyLysLysGluAlaAlaPro-28 30-SerAlaSerGluProAlaAla-36 38-SerSerAlaGlnGlyAspThrSerSerIleGly-48 61-AspIleGlyArgSerLeuLysGlnMetLysGluGlnGlyAlaGluIleAspLeu-78 89-TyrAspGlyLysGluIleLysMetThrGluGluGlnAlaGln-102 109-LeuGlnGluGlnGlnAlaLysAlaValGluLysHisLysAlaAspAlaLysAlaAsnLysGluLysGlyGlu AlaPheLeuLysGluAsnAlaAlaLysAspGlyValLysThrThrAlaSerGlyLeu-151 154-LysIleThrLysGlnGlyGluGlyLysGlnProThrLysAspAspIleVal-170 173-GluTyrGluGlyArgLeuIleAsp-180 183-ValPheAspSerSerLysAlaAsnGlyGly-192 210-GlnLeuLeuLysGluGlyGlyGlu-217 224-SerAsnLeuAlaTyrArgGluGlnGlyAlaGlyAspLysIleGlyProAsnAla-241 253-GlyAlaProGluAsnAlaProAlaLysGlnProAla-264 266-ValAspIleLysLysValAsn-272 Hydrophilic Regions - Hopp-Woods 21-CysGlyLysLysGluAlaAlaPro-28 30-SerAlaSerGluProAlaAla-36 40-AlaGlnGlyAspThrSerSer-46 61-AspIleGlyArgSerLeuLysGlnMetLysGluGlnGlyAlaGluIleAspLeu-78 89-TyrAspGlyLysGluIleLysMetThrGluGluGlnAlaGln-102 112-GlnGlnAlaLysAlaValGluLysHisLysAlaAspAlaLysAlaAsnLysGluLysGlyGluAlaPheLeu LysGluAsnAlaAlaLysAspGlyValLysThrThrAla-148 155-IleThrLysGlnGlyGluGlyLysGlnProThrLysAspAspIleVal-170 173-GluTyrGluGlyArgLeuIleAsp-180 185-AspSerSerLysAlaAsnGly-191 210-GlnLeuLeuLysGluGlyGlyGlu-217 227-AlaTyrArgGluGlnGlyAlaGlyAspLysIleGlyPro-239 253-GlyAlaProGluAsnAlaProAlaLysGlnProAla-264 266-ValAspIleLysLysValAsn-272 577 AMPHI Regions - AMPHI 8-GlyLysIleValGlyAsn-13 24-AlaAlaSerTyrProLysProCysLysSerPheLysLeuAla-37 62-ThrValIleLysIleIle-67 104-AlaPheValValGlyIleIlePheGlyMetPheAlaLeuPheGlyArg-119 144-GluLeuThrAlaProProAlaGln-151 Antigenic Index - Jameson-Wolf l-MetGluArgAsnGlyVal-6 14-ArgIleLeuArgMetSerSerGluHisAla-23 26-SerTyrProLysProCysLysSerPheLys-35 88-LeuProGlyGlnLysPheAspLeu-95 121-LeuSerLeuArgGlyGluAsnGlyArgLeuArgAlaGluValLysLysAsnAlaArgLeuThrGlyLysGlu LeuThrAlaProProAlaGlnAsnAlaProGluSerThrLysGlnPro-160 Hydrophilic Regions - Hopp-Woods l-MetGluArgAsnGlyVal-6 14-ArgIleLeuArgMetSerSerGluHisAla-23 29-LysProCysLysSerPheLys-35 121-LeuSerLeuArgGlyGluAsnGlyArgLeuArgAlaGluValLysLysAsnAlaArgLeuThrGlyLysGlu LeuThr-146 152-AsnAlaProGluSerThrLysGlnPro-160 578 AMPHI Regions - AMPHI lO-PheAlaAspPhePheLysAspPheAlaProGlnPheGlyGlyPheGlnAsn-26 34-AspPhePheAlaAlaPheLeuGlyGlyLeuGluGlyAsnMetGlyAsnThrAla-51 71-AsnAlaAspAlaAlaArgPhe-77 Antigenic Index - Jameson-Wolf 2-GlyLysLeuAspIle-6 13-PhePheLysAspPheAlaProGlnPheGlyGly-23 43-LeuGluGlyAsnMetGlyAsnThrAla-51 73-AspAlaAlaArgPheAlaGlu-79 90-GlnAsnl1eGlnThrGlyAsnAspPheArgLeuGlnArgGlyGlyValGly-106 Hydrophilic Regions - Hopp-Woods 2-GlyLysLeuAspIle-6 73-AspAlaAlaArgPheAlaGlu-79 96-AsnAspPheArgLeuGlnArg-102 579-1 AMPHI Regions - AMPHI 6-PheAspPheLeuHisLeuIleSerValSerGlyTrpGluHisLeuAlaGlu-22 49-ValAlaValMetArg-53 66-IleSerPheLeuCysAsn-71 115-LeuSerAsnPheAla-119 129-ProPheLysValGlyAspPheIleArgValGlyGlyPheGluGlyTyrValArgGluIleLys-149 258-GlnValValGluAsnLeuArg-264 Antigenic Index - Jameson-Wolf 110-SerLeuLysAspGlnLeuSer-116 128-ArgProPheLysVal-132 136-IleArgValGlyGlyPheGluGlyTyrValArgGluIleLysMet-150 154-SerLeuArgThrThrAspAsnGluGluValValLeu-165 175-IleValAsnArgSerThrLeu-181 198-LeuLysValAlaLysGluAlaValLeu-206 216-ValGlnAsnGluGluArgGlnAla-223 231-GlyAspAsnAlaIle-235 244-AsnGluAlaAspArgTrpThrLeu-251 253-CysAspLeuAsnGluGlnValValGluAsnLeuArgLysValAsn-267 271-ProPheProGlnArgAspIleHis-278 Hydrophilic Regions - Hopp-Woods 110-SerLeuLysAspGlnLeu-115 144-TyrValArgGluIleLysMet-150 155-LeuArgThrThrAspAsnGluGluValVal-164 198-LeuLysValAlaLysGluAlaValLeu-206 216-ValGlnAsnGluGluArgGlnAla-223 244-AsnGluAlaAspArgTrp-249 254-AspLeuAsnGluGlnValValGluAsnLeuArgLysValAsn-267 273-ProGlnArgAspIleHis-278 580 AMPHI Regions - AMPHI 47-ProValSerAlaSerLys-52 54-SerLeuValLysProLeuSerGlnProLeuAla-64 Antigenic Index - Jameson-Wolf l-MetAspSerProLysValGlyCysGly-9 35-ProPheGlyProThrMetPro-41 48-ValSerAlaSerLys-52 66-AlaArgProGluAlaAlaHis-72 81-ArgProGluAlaLeuAlaAspSerSerValSerProThrHisAlaThrSerGlyGluVal-100 Hydrophilic Regions - Hopp-Woods 1-MetAspSerProLysVal-6 66-AlaArgProGluAlaAlaHis-72 81-ArgProGluAlaLeuAla-86 96-ThrSerGlyGluVal-100 581 AMPHI Regions - AMPHI 43-SerHisPheIleSerLeu-48 56-ArgGluCysPheValGlyPhe-62 76-AlaThrAlaPheGlyArgIleAsnGln-84 91-ValHisGlyPheLeuThrThrPheAlaGlyArgIleAlaAsnProAlaHisCysGlnSerGlnThr-112 Antigenic Index - Jameson-Wolf 8-GlyGlnThrGlyIleGluGlnAsnThrPheCysArgArgGlyPheThrArgValAsnMetGlyGlyAsnThrAs pVal-33 35-ValGlnAlaAspArgGlyLeuThrSer-43 49-SerLysLeuGluThrGluValArgGluCysPhe-59 100-GlyArgIleAlaAsnProAlaHisCysGlnSerGlnThrAla-113 Hydrophilic Regions - Hopp-Woods 35-ValGlnAlaAspArgGlyLeu-41 49-SerLysLeuGluThrGluValArgGlu-57 582 AMPHI Regions - AMPHI 27-ThrAεpAsnValThrArgLeuAla-34 65-ValArgSerSerLeu-69 91-GlyGluThrAlaAspIleTyrThrProLeuSer-101 139-GlySerProThrArg-143 169-IleAlaGluAspLeuPhe-174 246-SerArgSerTrpAsnArglleTyrAlaMet-255 263-LeuThrValIleProArgValTrpValArgAlaPheAspGlnSer-277 286-IleAlaAspTyrMetGlyTyr-292 334-LeuLysGlyValValArgGlyPheHisGlyTyrGlyGlu-346 Antigenic Index - Jameson-Wolf 26-LeuThrAspAsnValThr-31 34-AlaCysTyrAspArg-38 44-LeuProSerSerAlaGlyGlnGluGlyGlnGluSerLysAla-57 63-GluThrValArgSerSerLeuAspLysGlyGluAla-74 77-ValValGluLysGlyGlyAspAlaLeuProAlaAεpSerAlaGlyGluThrAlaAsp-95 105-AspLeuAspLysAsnAspLeuArgGly-113 115-LeuGlyValArgGluHisAsnProMetTyr-124 131-AsnAsnSerProAsnTyrAlaProGlySerProThrArgGlyThrThrValGlnGluLyεPheGlyGlnGln LysArgAlaGluThrLysLeu-161 165-PheLysSerLysIleAlaGluAspLeuPheLysThrArgAla-178 183-GlyTyrThrGlnArgSerAεpTrpGlnIleTyrAsnGlnGlyArgLysSerAlaProPheArgAsnThrAsp TyrLysPro-209 216-ProValLysAlaAspLeuProPheGlyGlyArgLeuArgMet-229 237-GlnSerAsnGlyGlnSerArgProGluSerArgSerTrpAsn-250 273-AlaPheAspGlnSerGlyAspLysAsnAspAsnProAspIleAlaAsp-288 291-GlyTyrGlyAspValLysLeuGlnTyrArgLeuAsnAspArgGlnAsnVal-307 312-ArgTyrAsnProLysThrGlyTyr-319 330-IleLysGlyLysLeuLysGlyValVal-338 342-HisGlyTyrGlyGluSerLeuIleAspTyrAsnHisLyεGlnAsnGly-357 365-AsnAspLeuAspGlyIle-370 Hydrophilic Regions - Hopp-Woods 48-AlaGlyGlnGluGlyGlnGluSerLysAla-57 63-GluThrValArgSerSerLeuAspLysGlyGluAla-74 79-GluLysGlyGlyAspAlaLeuProAlaAspSerAlaGlyGluThrAlaAsp-95 105-AspLeuAspLysAsnAspLeuArgGly-113 115-LeuGlyValArgGluHisAsn-121 140-SerProThrArgGlyThrThrValGlnGluLysPheGlyGlnGlnLysArgAlaGluThrLysLeu-161 165-PheLyεSerLysIleAlaGluAεpLeuPheLysThrArgAla-178 195-GlnGlyArgLysSerAlaProPheArgAsnThrAspTyrLysPro-209 225-GlyArgLeuArgMet-229 239-AsnGlyGlnSerArgProGluSerArgSerTrp-249 274-PheAspGlnSerGlyAspLysAsnAspAsnProAspIleAlaAsp-288 293-GlyAspValLysLeu-297 299-TyrArgLeuAsnAspArgGlnAsn-306 332-GlyLysLeuLysGlyValVal-338 352-AsnHisLysGlnAsn-356 583 AMPHI Regions - AMPHI ll-HisLeuAlaPheCysAlaPheCysGlyIle-20 28-ArgLeuHisAsnArgMetTyrAsnAlaAlaAlaAlaArg-40 58-ValThrAspAlaGln-62 66-SerLysAsnGlyAspLysGlnIle-73 75-AspThrHisProGlnPro-80 117-GlyTyrAlaGlyTyrCysAspGln-124 140-AspAsnGlyGlyAsnHisThrAsp-147 162-GlyTyrGlyGlnCysGlnAsnGlnGlyAla-171 Antigenic Index - Jameson-Wolf 24-ThrAlaGlyAsnArgLeuHisAsnArgMetTyr-34 41-GlyIleGlyArgGlyAsnGlySerGlnGlnGlnPheGlyLysSerGluThrValThrAspAlaGlnArgPheS erSerLysAsnGlyAspLysGlnlleSerAspThrHisProGlnProCysPheGluGlnThrAlaArgAsnHisAs nCysAspGlyAsnGlnProAsnGlnArgIleGlyGluArgThrGlnArgIleAlaHisArgArgAlaArgPhe-11 4 117-GlyTyrAlaGlyTyCysAspGlnProAspGlyAsnAsnArgGlnArgAlaGlnArgHisGlyLeuAlaAspA snGlyGlyAsnHisThrAspLysHisGlyGlnGlnArgProSerLeuArgLeuAspProValGlyTyrGlyGlnCy sGlnAsnGlnGlyAlaGlnTyrCysGlyAsnGlyGluGlyTyrArgPhe-182 190-AspLeuArgLysLysAspArgProGluLysSerGluLys-202 Hydrophilic Regions - Hopp-Woods 27-AsnArgLeuHisAsn-31 41-GlyIleGlyArgGlyAsnGlySer-48 51-GlnPheGlyLysSerGluThrValThrAspAlaGlnArgPheSerSerLysAsnGlyAspLysGlnIleSerA spThrHisPro-78 84-GlnThrAlaArgAsnHisAsnCysAspGlyAsnGlnProAsnGlnArgIleGlyGluArgThrGlnArgIleA laHiεArgArgAlaArgPhe-114 123-AspGlnProAspGlyAsnAsnArgGlnArgAlaGlnArg-135 137-GlyLeuAlaAspAsnGlyGlyAsnHisThrAspLysHisGlyGlnGlnArgProSerLeuArgLeuAspPro -160 178-GluGlyTyrArgPhe-182 190-AspLeuArgLysLysAspArgProGluLysSerGluLys-202 584-2 AMPHI Regions - AMPHI 28-GluPheSerGluSerAlaGly-34 60-AlaGluPheValLysLysPheAsnLysPheIleArgLys-72 115-AspPheAspGluLeuAsnArgPheIleAlaAspIle-126 148-IleAspGlnValSerLysAsp-154 166-LeuAlaGlyValLeuGly-171 186-GlySerHisIleAla-190 196-GlnAlaLysMetLeuArgAlaMet-203 Antigenic Index - Jameson-Wolf 37-ValAlaGlnAspThrMetSer-43 50-AlaGluGlyArgAspLysAsnAlaVal-58 61-GluPheValLyεLysPheAsnLysPheIleArgLysSerLysAsnGlySerPheLysThrGluLeuValSerA rgSerAlaMetProArgTyrGlnTyrThrAsnGlyArgArglleGlnThrGlyTrpGluGluArgAlaGluPheLy ΞValGluGlyArgAspPheAspGluLeuAsn-120 138-HisValSerArgGluArgArgAsnGluValIleAspGlnValSerLysAspAlaValLeu-157 159-PheLysAlaArgAlaGluLysLeuAla-167 189-IleAlaGlyGlyGly-193 210-AsnMetGluGlyAlaAspSerAlaAlaProGlyValGluGluIleSer-225 Hydrophilic Regions - Hopp-Woods 50-AlaGluGlyArgAspLysAsnAlaVal-58 61-GluPheValLysLysPheAsnLysPheIleArgLysSerLysAsnGlySerPheLysThrGluLeuValSer- 84 95-AsnGlyArgArgIleGlnThrGlyTrpGluGluArgAlaGluPheLysValGluGlyArgAspPheAspGluL euAsn-120 138-HisValSerArgGluArgArgAsnGluValIleAspGlnValSerLysAεpAlaValLeu-157 159-PheLysAlaArgAlaGluLysLeuAla-167 210-AsnMetGluGlyAlaAspSerAlaAlaProGlyValGluGluIleSer-225 585 AMPHI Regions - AMPHI 6-ArgIlePheAlaThrPheCysAlaValIleValCys-17 46-ThrThrLeuMetGlySerIleIleSer-54 65-ArgGluIleLeuThrGluTrpLysAsp-73 93-AsnArgTyrIleAsp-97 133-LysAspTrpAspLysLeuGlnAlaArgArg-142 153-ProLeuAlaProIleTrp-158 178-LeuAlaGlyAsnIleAlaLysProIleArgIleLeuGlyAsnGlyMetAspArgValAla-197 223-PheAspLysMetValGluLysLeuGluLyεLeuVal-234 247-GluMetArgSerPro-251 255-MetGlnAlaIleValGlyLeuIle-262 273-LeuLysArgLeuGluGly-278 353-LeuTyrArgAlaPheAspAsnValIleArgAsnAlaValAsn-366 430-IleIleGluGlnHisCysGlyLysIleIleAlaGlu-441 Antigenic Index - Jameson-Wolf 36-AsnGlnPheAsnGlnArgArgThrIleGlu-45 56-PheArgAlaArgGlyAspAlaGlyAlaArgGluIleLeuThrGluTrpLysAspSerProValSer-77 84-GlnGlyAspGluLysLysAspIleLeu-92 99-TyrThrIleGluArgAlaArgLeu-106 120-GluTyrAspArgPheGlyGlu-126 133-LysAspTrpAspLysLeuGlnAlaArgArgLeuProSerPro-146 189-LeuGlyAsnGlyMetAspArgValAlaAsnGlyGluLeuGluThrArgIle-205 207-GlnGlnValAspAspArgAεpAεpGluLeuSer-217 225-LysMetValGluLysLeuGluLysLeuValAlaLysGluArgHiεLeu-240 246-HisGluMetArgSerProLeuAla-253 264-AlaGlnProGlnLysGlnGluGlnTyrLeuLysArgLeuGluGlyGluLeuThrArgMetAspThrLeuAla -287 294-SerArgLeuGluThrSerAsnMetAlaLeuGluLysGluSerLeuLys-309 317-LeuValGluAspAsnGlnSerIleAlaGlnLysAsnGlyGln-330 335-SerAlaAspGlyLysIleProGluAsnThr-344 367-TyrSerProGluGlySerThr-373 377-AsnIleGlyGlnAspHisLysHis-384 388-AspValThrAspAsnGlyProGlyValAspGluMetGln-400 409-TyrArgAlaAspSerSerAlaAsnLysProGlyThrGly-421 432-GluGlnHisCysGlyLysIleIleAlaGluAsnIleLysProAsnGlyLeuArg-449 453-1leLeuProLysLyεLysThrGlySerLysThrGluLysSerAlaAsn-468 Hydrophilic Regions - Hopp-Woods 37-GlnPheAsnGlnArgArgThrIleGlu-45 56-PheArgAlaArgGlyAspAlaGlyAlaArgGluIleLeuThrGluTrpLysAspSerProVal-76 84-GlnGlyAspGluLysLysAspIleLeu-92 100-ThrIleGluArgAlaArgLeu-106 120-GluTyrAspArgPheGlyGlu-126 133-LysAspTrpAspLyεLeuGlnAlaArgArgLeuPro-144 192-GlyMetAspArgValAlaAsnGlyGluLeuGluThrArgIle-205 207-GlnGlnValAspAspArgAspAspGluLeuSer-217 225-LysMetValGluLysLeuGluLysLeuValAlaLysGluArgHisLeu-240 246-HisGluMetArgSerProLeu-252 265-GlnProGlnLysGlnGluGlnTyrLeuLysArgLeuGluGlyGluLeuThrArgMetAspThrLeuAla-28 7 294-SerArgLeuGluThr-298 302-AlaLeuGluLysGluSerLeuLys-309 317-LeuValGluAspAsnGlnSerIleAlaGlnLysAsnGlyGln-330 336-AlaAspGlyLysIleProGlu-342 389-ValThrAspAsnGlyProGlyValAspGluMetGln-400 410-ArgAlaAspSerSerAlaAsnLysProGlyThr-420 438-IleIleAlaGluAsnIleLys-444 454-LeuProLysLysLysThrGlySerLysThrGluLysSerAlaAsn-468 586 AMPHI Regions - AMPHI 12-AspAsnPheLysTyrPheTrpLysThr-20 30-IleLeuAlaAlaLeuGly-35 56-ValLeuAlaAsnIleValGluLysAlaGlnSerLys-67 80-LeuGlnGlnSerTyrProHisSerIleSer-89 177-SerGlnGluAlaLeuLysAsnTyrGlyGlnAlaLeuGluLysMetProGlnAspSerValGlyArg-198 Antigenic Index - Jameson-Wolf 4-HisLeuGluGluGlnGlnGluLeuAspAsn-13 42-TyrGlnAsnArgLysValSerGlnAsnGlnGluAla-53 60-IleValGluLysAlaGlnSerLysAlaProGlnSerGluIleAsnAlaGluLeuThrLysLeuGlnGln-82 100-ThrGluPheAspAlaGlnArgTyrAspValAlaGluGly-112 118-LeuSerAsnGlnLysAspSerLeu-125 140-GlnGlnLysLysTyrAspAla-146 153-ThrProValGluAlaAspPhe-159 164-MetGluThrLysGlyAspVal-170 173-AlaGlnGlyLysSerGlnGluAlaLeuLyεAsnTyrGlyGlnAlaLeuGluLysMetProGlnAspSerVal GlyArgGluLeuVal-201 204-LysLeuAspSerLeuLys-209 Hydrophilic Regions - Hopp-Woods 4-HisLeuGluGluGlnGlnGluLeuAspAsn-13 43-GlnAsnArgLysValSerGlnAsnGlnGluAla-53 60-IleValGluLysAlaGlnSerLysAlaProGlnSerGluIleAsnAlaGluLeuThrLys-79 100-ThrGluPheAspAlaGlnArgTyrAspValAlaGluGly-112 120-AsnGlnLysAspSerLeu-125 140-GlnGlnLysLysTyrAspAla-146 153-ThrProValGluAlaAspPhe-159 164-MetGluThrLysGlyAspVal-170 174-GlnGlyLysSerGlnGluAlaLeuLys-182 187-AlaLeuGluLysMetProGlnAspSerValGlyArgGluLeuVal-201 204-LysLeuAspSerLeuLys-209 587 AMPHI Regions - AMPHI 6-LeuProAlaLeuProAlaIleLeuProLeuSerThr-17 190-AsnGlySerLysThrLeuSer-196 Antigenic Index - Jameson-Wolf 27-AspIleMetThrAspLysGlyLysTrpLysLeuGluThr-39 44-LeuAsnSerGluAsnAsnArgAlaGluLeu-53 72-GluIleGlnGluAsnGlySerAsnThrAsp-81 95-GlyAsnThrAspIleTyrGlySerGlySer-104 108-HisGluGluArgLysLeuAspGlyAsnSerLysThrArgAsnLysArgMetSerAsp-126 135-PheLeuLysAspAspLysAsnProAla-143 151-ThrValTyrGluLysSerArgAsnLysAlaSerSerGlyLysSer-165 187-TyrArgIleAsnGlySerLysThrLeuSerAspGlyIleArgTyrLysSerGlyAsnTyr-206 217-AlaAsnAspArgIleSerLeuThrGlyGly-226 231-GlyArgGlnProAspArgThrAspGlyLysArgGluSerSerArgAsnThrSerThr-249 273-ValSerGlyGlnSerSerSerGluLeuLysPhe-283 Hydrophilic Regions - Hopp-Woods 27-AspIleMetThrAspLysGlyLysTrpLysLeu-37 47-GluAsnAsnArgAlaGluLeu-53 72-GluIleGlnGluAsnGlySerAsnThr-80 108-HisGluGluArgLysLeuAspGlyAsnSerLysThrArgAsnLysArgMetSerAsp-126 135-PheLeuLysAspAspLysAsnPro-142 151-ThrValTyrGluLysSerArgAsnLysAlaSerSerGly-163 193-LysThrLeuSerAspGlyIleArgTyrLysSer-203 217-AlaAsnAspArgIleSer-222 232-ArgGlnProAspArgThrAspGlyLysArgGluSerSerArgAsnThr-247 277-SerSerSerGluLeuLysPhe-283 588 AMPHI Regions - AMPHI 52-GlnAspGlyArgAsnTyrThrGlySerPhe-61 99-GlyThrPheLysLys-103 Antigenic Index - Jameson-Wolf 25-SerTyrGlnGluProGlyCysThrTyrAspGlyAεnValGlyLyεAspGlyLysProAlaGlyLysGlyThrT rpArgCysGlnAspGlyArgAsnTyrThrGlySerPheLysAsnGlyLysPheAspGlyGlnGly-70 80-IlePheIleGluProPheAsnSerAspSerThrLysPheArg-93 100-ThrPheLysLysGlyLeuAlaHisGlyArgPheThrValSerGlnAsnGlyGluThr-118 124-CysGluAsnGlyMetIleLysGluValLysLeuProLysAsnLys-138 Hydrophilic Regions - Hopp-Woods 36-AsnValGlyLysAspGlyLysProAlaGly-45 47-GlyThrTrpArgCysGlnAspGlyArgAsnTyr-57 61-PheLysAsnGlyLysPheAspGly-68 85-PheAsnSerAspSerThrLysPheArg-93 100-ThrPheLysLysGlyLeuAla-106 124-CysGluAsnGlyMetIleLysGluValLysLeuProLysAsnLys-138 589 AMPHI Regions - AMPHI 18-AlaSerArgIleGluLysValLeu-25 54-ValAlaAspIlAlaLysIleIleGluLys-63 125-SerValValGlnLeuTrpLeuAla-132 150-MetAspValLeuValThrIle-156 193-PheValSerLeuGlyLysPheLeuGluHisArg-203 225-ValGlnArgAsnGlyGlu-230 240-GlnIleGlyAspLeuIleArg-246 307-GlnThrGlnLeuGlyAspMetMetAsnAlaLeuSerGluAlaGln-321 325-AlaProIleAlaArgValAlaAspLys-333 391-MetGlyLysAlaVal-395 466-IleValSerAlaAlaGln-471 477-IleProAlaAlaGln-481 497-GlyValGlyLeuValLys-502 511-LeuAlaLeuProLysPheLeuAspGlyValTrpAspIleAlaSerIle-526 539-PheAlaLeuAlaAspAlaLeuLys-546 548-AspThrAlaGluAlaIleGlyArgLeu-556 598-GluValGlnLysLeuLysAlaAla-605 612-ValGlyAspGlyIleAsnAspAlaPro-620 635-AlaAspValAlaGluHisThr-641 648-GlnHisSerValAsnGlnLeuAlaAsp-656 675-AlaPhePheTyrAsnIleLeu-681 Antigenic Index - Jameson-Wolf l-MetGlnGlnLysIleArgPheGlnIle-9 17-CysAlaSerArgIleGluLysValLeuAsnLysLysAspPheValGluSer-33 39-AlaSerGluGluAlaGlnValValPheAspAspSerLysThrSerVal-54 59-LysIleIleGluLysThrGlyTyrGlyAlaLysGluLysThrGluAspThrLeuProGlnProGluAlaGluH is-83 109-GlyArgHisAspTrp-113 143-IleLysGlyGlyLeu-147 200-LeuGluHisArgThrLysLysSerSerLeuAsn-210 223-ValAsnValGlnArgAsnGlyGluTrpLysGlnLeuProIleAspGln-238 248-AsnHisGlyGluArgIleAlaAla-255 257-GlyIleIleGluSerGlySerGlyTrpAlaAspGluSerHisLeuThrGlyGluSerAsnProGluGluLys LysAlaGlyGly-284 293-ThrGluGlySerVal-297 318-SerGluAlaGlnGlySerLysAlaProIle-327 329-ArgVa1A1aAspLysAlaAla-335 356-IleLysGlyAspTrp-360 391-MetGlyLysAlaValLys-396 404-AlaAlaAlaMetGluGluAlaAlaHis-412 417-ValLeuAspLysThrGlyThrLeuThrGluGlySerProGln-430 438-ProAspSerGlyPheAspGluAspAlaLeu-447 454-ValGluGlnAsnAla-458 493-AlaGluValGluGly-497 502-LysAlaGlyLysAlaGluPheAla-509 530-SerValAspAsnLysProIleGly-537 543-AspAlaLeuLysAlaAspThrAlaGluAlaIleGlyArgLeuLysLysHisAsnIle-561 567-SerGlyAspAsnGlnGlyThrValGluTyrValAla-578 588-GlyAsnMetSerProArgAspLysAlaAlaGluValGlnLysLeuLysAlaAlaGly-606 612-ValGlyAspGlyIleAsnAspAla-619 631-MetLysGlyGlyAlaAspValAlaGlu-639 710-AsnAlaLeuArgLeuLysArgValLysIleAsp-720 Hydrophilic Regions - Hopp-Woods l-MetGlnGlnLysIleArgPheGlnIle-9 19-SerArgIleGluLysValLeuAsnLyεLysAspPheValGlu-32 39-AlaSerGluGluAlaGlnValValPheAspAspSerLysThrSerVal-54 64-ThrGlyTyrGlyAlaLysGluLysThrGluAspThrLeuProGlnProGluAlaGluHis-83 200-LeuGluHisArgThrLysLysSerSerLeu-209 224-AsnValGlnArgAsnGlyGluTrpLys-232 248-AsnHisGlyGluArgIleAlaAla-255 257-GlyIleIleGluSer-261 265-TrpAlaAspGluSerHisLeuThrGlyGluSerAsnProGluGluLysLysAlaGlyGly-284 318-SerGluAlaGlnGlySerLysAlaProIle-327 329-ArgValAlaAspLysAlaAla-335 404-AlaAlaAlaMetGluGluAlaAlaHis-412 417-ValLeuAspLysThrGlyThrLeuThrGluGlySerPro-429 440-SerGlyPheAspGluAspAlaLeu-447 454-ValGluGlnAsnAla-458 493-AlaGluValGluGly-497 502-LysAlaGlyLysAlaGluPheAla-509 531-ValAspAsnLysPro-535 543-AspAlaLeuLysAlaAspThrAlaGluAlaIleGlyArgLeuLysLysHisAsnIle-561 568-GlyAspAsnGlnGly-572 591-SerProArgAspLysAlaAlaGluValGlnLysLeuLysAlaAlaGly-606 633-GlyGlyAlaAspValAlaGlu-639 712-LeuArgLeuLysArgValLysIleAsp-720 590-1 AMPHI Regions - AMPHI 77-TyrLeuProAspAsnLeuLysThrValLeuGluGlnProValThrLeuValAsnHisIleThrHis-98 100-ProPheAlaGlyGlyPhe-105 123-LysValLeuGluArgPhePheGly-130 132-GlnValProAlaSerLeu-137 177-TyrGlnLysGlyPheLysSerTyrArgAsnGly-187 214-ThrSerAspGlyIleAsnProLeu-221 248-AsnGluLeuValAsnLeuVal-254 331-LysArgLysPheAla-335 420-LysMetLeuGluAsp-424 450-AsplleAsnGluThrLeuArgLeuMet-458 460-AspSerThrValGln-464 Antigenic Index - Jameson-Wolf 1-MetLysLysProLeu-5 26-LysAlaGluGluSerLeuThrGlnGlnGlnLysIleLeuGln-39 47-GluSerHisGlnTyrGluArgGlyTrp-55 62-ThrValIleArgLeuLysProGluLeu-70 72-AsnAsnAlaArgLysTyrLeuProAspAsnLeuLysThrValLeu-86 113-ThrGluPheLysTyrAlaProGluThrGluLysValLeuGlu-126 128-PhePheGlyLysGlnValPro-134 144-AsnGlySerGlyLysMetGluVal-151 157-AspTyrGluGluLeuSerGly-163 175-ThrValTyrGlnLysGlyPheLysSerTyrArgAsnGlyTyrAspAlaPro-191 196-LysLeuAlaAspLysGlyAspAlaAlaPheGlu-206 208-ValHisPheAspSerGluThrSerAspGlyIleAsn-219 233-PheSerLeuGluTrpLysGluGlyValAspTyr-243 264-AsnProAsnGlySerIleAlaProSerLysIleGluValGly-277 281-PheSerThrLysThrGlyGluSerGlyAla-290 292-IleAsnSerGluGlyGlnPheArgPheAspThr-302 304-ValTyrGlyAspGluLysTyrGlyPro-312 330-LeuLysArgLysPheAla-335 338-SerAlaLysLysMetThrGluGluGlnIleArgAsnAspLeu-351 355-ValLysGlyGluAlaSerGlyLeuPheThrAsnAsnProValLeuAsp-370 378-LeuProSerGlyLysIleAspValGlyGly-387 389-IleMetPheLysAspMetLysLysGluAspLeuAsnGln-401 406-LeuLysLysThrGluAlaAspIleArgMet-415 437-AsnAlaGluAspGluAlaGluGlyArgAlaSerLeuAspAspIleAsnGluThrLeu-455 466-MetAlaArgGluLysTyr-471 475-AsnGlyAspGlnIleAsp-480 485-LeuLysAsnAsnGlnLeuLysLeuAsnGlyLysThrLeuGlnAsnGluProGluProAspPheAspGluGly GlyMetValSerGluProGlnGln-516 Hydrophilic Regions - Hopp-Woods l-MetLysLysProLeu-5 26-LysAlaGluGluSerLeuThrGln-33 62-ThrValIleArgLeuLysProGluLeu-70 72-AsnAsnAlaArgLysTyrLeuProAspAsnLeuLysThrValLeu-86 113-ThrGluPheLysTyrAlaProGluThrGluLysValLeuGlu-126 147-GlyLysMetGluVal-151 157-AspTyrGluGluLeuSerGly-163 180-GlyPheLysSerTyrArgAsnGlyTyr-188 196-LysLeuAlaAspLysGlyAspAlaAlaPheGlu-206 208-ValHisPheAspSerGluThrSerAspGly-217 233-PheSerLeuGluTrpLysGluGlyValAspTyr-243 272-SerLysIleGluValGly-277 306-GlyAspGluLysTyrGlyPro-312 330-LeuLysArgLysPheAla-335 338-ΞerAlaLysLysMetThrGluGluGlnIleArgAsnAspLeu-351 355-ValLysGlyGluAla-359 381-GlyLysIleAspValGlyGly-387 389-IleMetPheLysAspMetLysLysGluAspLeuAsn-400 406-LeuLysLysThrGluAlaAspIleArgMet-415 437-AsnAlaGluAspGluAlaGluGlyArgAlaSerLeuAspAspIleAsnGluThrLeu-455 466-MetAlaArgGluLysTyr-471 486-LysAsnAsnGlnLeuLysLeuAsnGly-494 496-ThrLeuGlnAsnGluProGluProAspPheAspGluGlyGlyMetValSerGluProGlnGln-516 591 AMPHI Regions - AMPHI 6-AlaPheIlePheAla-10 17-LeuHisGluPheGlyHisTyrIleValAla-26 61-LeuGlyGlyTyrValLysMetValAsp-69 143-GlyAspLysIleGlnSerValAsnGlyThrProValAlaAspTrp-157 181-SerGlyAlaGlnThrValArgThrIleAspAlaAlaGlyThrProGluAlaGlyLysIleAlaLys-202 218-AlaGlyGlyValGluLys-223 234-ProGlyAspArgLeu-238 245-ProIleAlaSerTrpGlnGluTrpAlaAsnLeuThrArg-257 270-ArgAlaGlyGlnThr-274 304-AlaTrpAspAlaGlnIleArg-310 313-TyrArgProSerValValArgAlaPheGly-322 324-GlyTrpGluLysThrValSerHis-331 335-ThrLeuLysPhePheGlyLysLeuIle-343 351-HisIleSerGlyProLeuThrIleAla-359 373-TyrLeuGluPheLeuAlaLeu-379 Antigenic Index - Jameson-Wolf 44-PhePheThrArgLysArgGlyAspThrGlu-53 68-ValAspThrArgGluGlyGluValSerGluAlaAspLeu-80 84-PheAεpLysGlnHisProAlaLysArg-92 129-ValGluProAspThrIleAla-135 139-GlyPheGlnSerGlyAspLysIleGlnSer-148 157-TrpGlySerAlaGln-161 187-ArgThrIleAspAlaAlaGlyThrProGluAlaGlyLysIleLysAsnGlnGly-205 219-GlyGlyValGluLysGlySerProAlaGluLysAlaGlyLeuLysProGlyAspArgLeuThrAlaAlaAsp GlyLysProIle-246 254-AsnLeuThrArgGlnSerProGlyLysLysIle-264 267-AsnTyrGluArgAlaGlyGlnThrHis-275 277-AlaAspIleArgProAspThrValGluGlnSerAspHis-289 295-ValGlyLeuArgProGlnProAspArgAlaTrp-305 307-AlaGlnIleArgArgSerTyrArgProSerVal-317 327-LysThrValSerHisSer-332 343-IleSerGlyAsnAla-347 362-AlaGlyGlnSerAla-366 408-IleArgGlyLysProLeuGlyGluArgValGln-418 Hydrophilic Regions - Hopp-Woods 44-PhePheThrArgLysArgGlyAspThr-52 68-ValAspThrArgGluGlyGluValSerGluAlaAspLeu-80 84-PheAspLysGlnHiεProAlaLyεArg-92 129-ValGluProAspThrIleAla-135 139-GlyPheGlnSerGlyAspLysIleGlnSer-148 193-GlyThrProGluAlaGlyLysIleAlaLys-202 220-GlyValGluLysGlySerProAlaGluLysAlaGlyLeuLysProGlyAspArgLeuThrAlaAlaAspGly LysPro-245 256-ThrArgGlnSerProGlyLysLysIle-264 268-TyrGluArgAlaGlyGln-273 277-AlaAspIleArgProAspThrValGluGlnSerAsp-288 299-ProGlnProAspArgAlaTrp-305 308-GlnIleArgArgSerTyrArg-314 362-AlaGlyGlnSerAla-366 411-LysProLeuGlyGluArgValGln-418 592 AMPHI Regions - AMPHI 6-PheGlyGlnIlePheSer-ll 21-GlyGlyLeuLeuGlyGlyLeuIle-28 50-AlaProAsnAlaAlaAlaAlaAla-57 65-GlnGlyMetIleGlnMetLeuGlyValPheValAsp-76 94-ProTyrGlyAspLeu-98 109-ValSerGlnValGlyGlnTrp-115 153 -ThrAlaVa1PheArgMet-158 165-TyrPheGlyAlaValAla-170 185-IleMetAlaTrpIleAsnLeuValAlaIleLeuLeuLeuSer-198 Antigenic Index - Jameson-Wolf 35-GlyIleLysArgGlyLeuTyrSerAsnGluAlaGlyMetGlySerAlaProAsnAla-53 57-AlaGluValLysHisProVal-63 93-GlnProTyrGlyAspLeuSerGly-100 137-AlaTyrAlaGluSerAsnVal-143 206-ArgAspTyrThrAlaLysLeuLysMetGlyLysAspProGluPheLysLeuSerGluHisProGlyLeuLys ArgArgIleLysSerAspValTrp-237 Hydrophilic Regions - Hopp-Woods 35-GlyIleLysArgGlyLeuTyr-41 57-AlaGluValLysHis-61 212-LeuLysMetGlyLysAspProGluPheLysLeuSerGlu-224 226-ProGlyLeuLysArgArgIleLysSer-234 593 AMPHI Regions - AMPHI 6-GlyLeuCysLysArgPheGlyAsnLysThr-15 41-SerThrLeuLeuAsnIleIleAlaGlyIle-50 87-HisMetSerAlaLeuGlu-92 125-AlaHisArgLysProGluLysLeuSerGlyGlyGlu-136 159-PheSerSerLeuAsp-163 165-HisLeuArgGlyThrLeuArg-171 216-ProGluThrLeuValLysThrProSerCysValGlnValAlaArgLeuMetGlyLeu-234 Antigenic Index - Jameson-Wolf 6-GlyLeuCysLysArgPheGlyAsnLysThrValAla-17 24-ValGlyArgGlyLysIle-29 33-LeuGlyArgSerGlyCysGlyLysSerThr-42 50-IleValArgProAspGlyGlyGlu-57 61-AsnGlyGluAsnIleThrArgMetProProGluLysArgArgIle-75 99-LysMetGlnLysMetProLysAlaGluAlaGluArgLeuAla-112 119-ValGlyLeuGluAsnGluAlaHisArgLysProGluLysLeuSerGlyGlyGluLysGlnArgLeuAlaLeu -142 157-GluSerPheSerSerLeu-162 168-GlyThrLeuArgArgMetThrAlaGluArgIleArgAsnGlyGlyIle-183 190-HisSerProGluGluAlaCysThrThrAlaAspGluIleAlaVal-204 206-HisLysGlyArgIle-210 214-GlyThrProGluThrLeuValLysThrProSer-224 233-GlyLeuProAsnThrAspAspAsnArgHisIle-243 248-ValArgPheAεpGlnAspGlyMetGluCysArgValLeuSer-261 263-ThrCysLeuProGluSer-268 291-GlyAlaValSerGlyLysAspThrVal-299 302-HisIleGluGluArgGluIleValArgPheArg-312 Hydrophilic Regions - Hopp-Woods 6-GlyLeuCysLysArgPheGlyAsn-13 25-GlyArgGlyLysIle-29 36-SerGlyCysGlyLys-40 51-ValArgProAspGlyGly-56 68-MetProProGluLysArgArgIle-75 99-LysMetGlnLysMetProLysAlaGluAlaGluArgLeuAla-112 119-ValGlyLeuGluAsnGluAlaHisArgLysProGluLysLeuSerGlyGlyGluLysGlnArgLeuAlaLeu -142 168-GlyThrLeuArgArgMetThrAlaGluArgIleArgAsn-180 191-SerProGluGluAlaCysThrThrAlaAspGluIleAlaVal-204 206-HisLysGlyArgIle-210 236-AsnThrAspAspAsnArgHisIle-243 248-ValArgPheAspGlnAspGlyMetGluCysArgValLeuSer-261 293-ValSerGlyLysAspThrVal-299 302-HisIleGluGluArgGluIleValArgPheArg-312 594 AMPH Regions - AMPHI 21-SerIleLeuArgLeu-25 108-AlaGlyArgGluCysGlnGluThrAlaAlaAla-118 138-AlaIleLysArgCysAsn-143 Antigenic Index - Jameson-Wolf l-MetGlyAlaAspThrAspGlyAspLysAεpValArgLeuAsnArgThr-16 51-ValGluHisProAsnArgPhe-57 75-HisLeuAspGlySerThrGlyGly-82 86-PheArgArgGluLysThrGlyHisLysArgArgCysHisThrGlnCys-101 103-HisSerAlaArgAlaAlaGlyArgGluCysGlnGluThr-115 137-ArgAlaIleLysArgCysAsn-143 Hydrophilic Regions - Hopp-Woods l-MetGlyAlaAspThrAspGlyAspLysAspValArgLeuAsnArg-15 86-PheArgArgGluLysThrGlyHiSLysArgArgCysHis-98 105-AlaArgAlaAlaGlyArgGluCysGlnGluThr-115 137-ArgAlaIleLysArgCysAsn-143 595 AMPHI Regions - AMPHI 20-CysGlnProProGluAla-25 140-AlaAspLeuGluLysLeuSerGlnProLeuAla-150 157-GlnGlyGluValLysGluLeuVal-164 169-ThrPheThrGluAlaValLysAlaGlyAspIleGluLysAla-182 196-IleGluProIleAlaGluLeuPheSerGluLeuAspPro-208 224-AlaGlyPheThrGlyPheHisArg-231 243-SerGlyValLysGluIleAlaAlaLysLeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 274-ValGlyGlyAlaSerGluLeuIleGluGluValAlaGly-286 309-AspGlySerLysLysIleValAspLeuPheArgProLeu-321 337-PheLysGlnValAsnGluIleLeuAlaLys-346 351-AspGlyPheGluThrTyrAspLysLeuGlyGlu-361 366-AlaLeuGlnAlaSerIleAsnAlaLeuAlaGluAspLeuAlaGlnLeuArgGlyIleLeuGlyLeu-387 Antigenic Index - Jameson-Wolf 1-MetArgLysPheAsn-5 21-GlnProProGluAlaGluLysAlaAlaPro-30 32-AlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySer-44 50-AsnAspAsnAlaCysGluProMetGlu-58 70-1leLysAsnAsnSerGlyArgLysLeuGluTrpGluIle-82 87-MetValValAspGluArgGluAsnIleAla-96 98-GlyLeuSerAspLysMetThr-104 108-LeuProGlyGluTyrGluMet-114 120-ThrAsnProArgGlyLysLeuValValThrAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGlu LysLeuSer-146 158-GlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGlyAspIleGluLys AlaLysSerLeuPheAla-187 189-Thr rgValHisTyrGluArgIleGluProIle-199 204-SerGluLeuAspProValIleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGly-225 238-ValGluLysAspValSerGlyValLysGluIleAlaAla-250 252-LeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 269-ProProGlyLysValValGlyGlyAla-277 279-GluLeuIleGluGluValAlaGlySerLysIleSerGlyGluGluAεpArgTyrSerHisThrAspLeuSer AspPheGlnAlaAsnValAspGlySerLysLysIleValAsp-316 322-IleGluAlaLysAsnLysAlaLeuLeuGluLysThrAspThrAsnPheLysGlnValAsn-341 345-AlaLysTyrArgThrLysAspGlyPheGluThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeu-36 7 374-LeuAlaGluAspLeuAlaGln-380 Hydrophilic Regions - Hopp-Woods 1-MetArgLysPheAsn-5 21-GlnProProGluAlaGluLysAlaAlaPro-30 32-AlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySer-44 52-AsnAlaCysGluProMetGlu-58 72-AsnAsnSerGlyArgLysLeuGluTrpGluIle-82 87-MetValValAspGluArgGluAsnIle-95 99-LeuSerAspLysMetThr-104 110-GlyGluTyrGluMet-114 122-ProArgGlyLysLeuValVal-128 131-SerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuSer-146 158-GlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGlyAspIleGluLys AlaLysSerLeuPheAla-187 189-ThrArgValHisTyrGluArgIleGluProIle-199 204-SerGluLeuAspProValIleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGly-225 238-ValGluLysAspValSerGlyValLysGluIleAlaAla-250 252-LeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 279-GluLeuIleGluGluValAlaGly-286 288-LysIleSerGlyGluGluAspArgTyrSerHis-298 308-ValAspGlySerLysLysIleValAsp-316 322-IleGluAlaLysAsnLysAlaLeuLeuGluLysThrAspThrAsnPhe-337 347-TyrArgThrLysAspGlyPheGluThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeu-367 374-LeuAlaGluAspLeuAlaGln-380 596 AMPHI Regions - AMPHI 9-MetLeuArgValSerLysValVal-16 50-LeuArgIleMetAlaGlyValAspLys-58 87-ValArgGluGluValGluSerGlyLeuGlyGluValAlaAlaAlaGlnLysArgLeuGluGluValTyrAlaG luTyr-112 192-ProThrAsnHisLeuAsp-197 202-GluTrpLeuGluGlnPheLeuValArgPheProGly-213 295-AlaArgPheGluGluMetSerAsnTyr-303 322-LeuGlyAsnGluValIleGluPheValAsnValSerLysSerPhe-336 366-SerThrLeuPheLysMet-371 409-AspAsnIleAlaGlu-413 440-AspGlnSerLysIleAlaGlyGlnLeuSerGlyGlyGlu-452 483-LeuArgAlaLeuGluAspAlaLeuLeuGluPheAla-494 Antigenic Index - Jameson-Wolf 16-ValProProGlnLysThrIleIleLysAspIleSer-27 41-LeuAsnGlyAlaGlyLysSerThrVal-49 54-AlaGlyValAspLysGluPheGluGlyGluAla-64 75-LeuProGlnGluProGluLeuAspProGluLysThrValArgGluGluValGluSerGlyLeu-95 99-AlaAlaAlaGlnLysArgLeuGluGluValTyr-109 112-TyrAlaAsnProAspAlaAspPheAspAlaLeuAlaGluGluGlnGlyArgLeuGlu-130 136-GlySerSerThrGlyGlyGlyAlaGluHisGluLeuGluIleAlaAlaAspAlaLeuArg-155 157-ProGluTrpAspAlaLysIleAspAsnLeuSerGlyGlyGluLysArgArgValAla-175 181-LeuSerLysProAspMet-186 190-AspGluProThrAsnHisLeuAspAlaGluSer-200 219-ThrHisAspArgTyrPhe-224 233-LeuGluLeuAspArgGlyHisGlyIle-241 243-TrpLysGlyAsnTyrSerSer-249 251-LeuGluGlnLysGluLysArgLeuGluAsnGluAlaLysSerGluAlaAlaArgValLysAlaMetLysGln GluLeuGluTrp-278 280-ArgGlnAsnAlaLysGlyArgGlnAlaLysSerLysAlaArgLeuAlaArgPheGluGluMetSerAsnTyr GluTyrGlnLysArgAsnGluThrGlnGlu-313 319-AlaGluArgLeuGlyAsnGluVal-326 333-SerLysSerPheGlyAsp-338 360-ProAsnGlyAlaGlyLysSerThrLeu-368 372-IleSerGlyLysGluGlnProAspSerGlyGluValLysIle-385 395-AspGlnSerArgGluGlyLeuGlnAsnAspLysThrVal-407 411-IleAlaGluGlyArgAspIleLeu-418 425-IleProAlaArgGlnTyrLeuGlyArgPheAsnPheLysGlySerAspGlnSerLysIleAla-445 447-GlnLeuSerGlyGlyGluArgGlyArgLeuHisLeu-458 471-LeuAspGluProSerAsnAspLeuAspValGluThr-482 501-SerHisAspArgTrpPhe-506 516-AlaCysGluGlyAspSerLysTrp-523 527-AspGlyAsnTyrGlnGluTyrGluAlaAspLysLysArgArgLeuGlyGluGluGlyAlaLysProLysArg IleLysTyrLysProValThrArg-558 Hydrophilic Regions - Hopp-Woods 54-AlaGlyValAspLysGluPheGluGlyGluAla-64 77-GlnGluProGluLeuAspProGluLysThrValArgGluGluValGluSerGlyLeu-95 99-AlaAlaAlaGlnLysArgLeuGluGluValTyr-109 113-AlaAsnProAspAlaAspPheAspAlaLeuAlaGluGluGlnGlyArgLeuGlu-130 141-GlyGlyAlaGluHisGluLeuGluIleAlaAlaAspAlaLeuArg-155 157-ProGluTrpAspAlaLys11eAspAsn-165 167-SerGlyGlyGluLysArgArgValAla-175 181-LeuSerLysProAsp-185 190-AspGluProThrAsn-194 196-LeuAspAlaGluSer-200 233-LeuGluLeuAspArgGlyHis-239 251-LeuGluGlnLysGluLysArgLeuGluAsnGluAlaLysSerGluAlaAlaArgValLysAlaMetLysGln GluLeuGluTrp-278 280-ArgGlnAsnAlaLysGlyArgGlnAlaLysSerLysAlaArgLeuAlaArgPheGluGluMetSerAsn-30 2 304-GluTyrGlnLysArgAsnGluThrGln-312 319-AlaGluArgLeuGlyAsnGluVal-326 372-IleSerGlyLysGluGlnProAspSerGlyGluValLysIle-385 395-AspGlnSerArgGluGlyLeuGlnAsnAspLysThrVal-407 411-IleAlaGluGlyArgAspIleLeu-418 435-AsnPheLysGlySerAspGlnSerLysIle-444 449-SerGlyGlyGluArgGlyArgLeuHiεLeu-458 472-AspGluProSerAsnAspLeuAεpValGluThr- 82 517-CyεGluGlyAspSer-521 529-AsnTyrGlnGluTyrGluAlaAspLysLysArgArgLeuGlyGluGluGlyAlaLysProLysArgIleLys Tyr-553 597-2 AMPHI Regions - AMPHI 30-AlaGluValLysLys-34 66-LysGluAlaAlaLysGluGlyLysGluSerLysLysThrAlaLys-80 93-GlnSerAlaArgLysGlyArgGluGly-101 112-AlaHisGlyLysPro-116 141-GlnGlyAsnProArgLysGlyGlyLys-149 163-SerAspLysAsnGlyLysAlaValLyεGlnAspLysLysTyrArgGluGluLysAsn-181 217-ValSerAsnSerLeuLysGlnLeuGlnGlu-226 252-TrpAspLysPheGlnLysLeu-258 275-GlnIleSerArgPheValSerGly-282 308-LeuArgTyrThrArgTyrValAsnAla-316 318-AsnArgGluValValLysAspLeuGluLysGlnGln-329 339-IleAsnAsnGluLeuAlaArgLeuLysLys-348 351-AlaAsnValGlnSerLeu-356 364-AspAlaAlaGluGlnThrGlu-370 376-AlaLysIleAlaLysAspAlaArg-383 396-AsnLysLeuLeuSer-400 460-ProSerValMetGlyIleGlySerAlaAspGlyPheSerArgMetGlnGlyArgLeuLysLysProValAsp GlyValProThrGly-488 509-ProAlaThrValGluSerIleAla-516 521-SerTyrAlaAspGluLeuAspGlyTyrGlyLys-531 543-SerIleTyrAlaGlyLeu-548 Antigenic Index - Jameson-Wolf 23-AspAlaAlaHisAsnArgSerAlaGluValLysLysGlnThrLysAsnLysLysGluGlnProGluAlaAlaG luGlyLysLysGluLysGlyLysAsnGlyAlaValLysAspLysLysThrGlyGlyLysGluAlaAlaLysGluGl yLysGluSerLysLysThrAlaLysAsnArgLysGluAlaGluLysGluAlaThrSerArgGlnSerAlaArgLys GlyArgGluGlyAspLysLysSerLyεAlaGluHisLysLysAlaHisGlyLysProValSerGlySerLysGluL ysAsnAlaLysThrGlnProGluAsnLysGlnGlyLysLysGluAlaLysGlyGlnGlyAsnProArgLysGlyGl yLysAlaGluLysAspThrValSerAlaAsnLysLysValArgSerAspLysAsnGlyLysAlaValLysGlnAsp LysLysTyrArgGluGluLysAsnAlaLysThrAspSerAspGluLeuLysAla-191 196-AlaThrAsnAspValGluAsnLysLysAlaLeuLeuLysGlnSerGluGly-212 219-AsnSerLeuLysGlnLeuGlnGluGluArglleArgGlnGluArgIleArgGlnAlaArgGlyAsnLeu-24 1 243-SerValAsnArgLysGlnArgGluAlaTrpAspLysPheGlnLysLeuAsnThrGluLeuAsnArgLeuLys ThrGluValAlaAla-271 281-SerGlyAsnTyrLysAsnSerGlnProAsn-290 298-AsnAlaGluProGlyGlnLysAsnArgPhe-307 314-ValAsnAlaSerAsnArgGluValValLysAspLeuGluLysGlnGlnLys-330 335-GlnGluGlnLysIleAsnAsnGluLeuAlaArgLeuLysLysIleGln-350 356-LeuLeuLysLysGlnGlyValThrAspAlaAlaGluGlnThrGluSerArgArgGlnAsnAlaLysIleAla LysAspAlaArgLysLeuLeuGluGlnLysGlyAsnGluGlnGlnLeu-395 398-LeuLeuSerAsnLeuGluLysLysLyεAlaGluHisArgIleGlnAspAlaGluAlaLysArgLysLeuAla GluAlaArgLeuAlaAlaAlaGluLysAlaArgLysGluAlaAlaGlnGlnLysAlaGluAlaArgArgAlaGluM etSerAsnLeuThrAlaGluAspArgAsnIleGlnAlaProSer-461 466-GlySerAlaAspGlyPheSerArgMetGlnGlyArgLeuLysLysProValAspGlyValProThr-487 491-GlyGlnAsnArgSerGlyGlyAspIle-499 521-SerTyrAlaAspGluLeuAspGlyTyrGly-530 536-AspHisGlyGluAsnTyr-541 561-AlaGlySerLysIleGlySerSerGlySerLeuProAspGlyGluGluGlyLeu-578 588-ValLeuAsnProSerSerTrp-594 Hydrophilic Regions - Hopp-Woods 23-AspAlaAlaHisAsnArgSerAlaGluValLysLysGlnThrLysAsnLysLysGluGlnProGluAlaAlaG luGlyLyεLysGluLysGlyLysAsnGlyAlaValLysAspLysLysThrGlyGlyLysGluAlaAlaLysGluGl yLysGluSerLysLysThrAlaLysAsnArgLysGluAlaGluLysGluAlaThrSerArgGlnSerAlaArgLys GlyArgGluGlyAspLysLysSerLysAlaGluHisLysLysAlaHisGlyLysProValSerGlySerLysGluL ysAsnAlaLysThrGlnProGluAsnLysGlnGlyLysLysGluAlaLysGlyGlnGlyAsnProArgLysGlyGl yLysAlaGluLysAspThrValSerAlaAsnLysLysValArgSerAspLysAsnGlyLysAlaValLysGlnAsp LysLysTyrArgGluGluLysAsnAlaLysThrAspSerAspGluLeuLysAla-191 198-AsnAspValGluAsnLysLysAlaLeuLeuLysGlnSerGlu-211 220-SerLeuLysGlnLeuGlnGluGluArgIleArgGlnGluArgIleArgGlnAlaArgGlyAsn-240 244-ValAsnArgLysGlnArgGluAlaTrpAspLysPheGlnLysLeuAsnThrGluLeuAsnArgLeuLysThr GluValAlaAla-271 284-TyrLysAsnSerGln-288 298-AεnAlaGluProGlyGlnLysAsnArgPhe-307 317-SerAsnArgGluValValLysAspLeuGluLysGlnGlnLys-330 335-GlnGluGlnLysIleAsnAsnGluLeuAlaArgLeuLysLysIleGln-350 356-LeuLeuLysLysGlnGlyValThrAspAlaAlaGluGlnThrGluSerArgArgGlnAsnAlaLysIleAla LysAspAlaArgLysLeuLeuGluGlnLysGlyAsnGluGlnGlnLeu-395 400-SerAsnLeuGluLysLysLysAlaGluHisArgIleGlnAspAlaGluAlaLysArgLysLeuAlaGluAla ArgLeuAlaAlaAlaGluLysAlaArgLysGluAlaAlaGlnGlnLysAlaGluAlaArgArgAlaGluMet-447 451-ThrAlaGluAspArgAsnIleGln-458 474-MetGlnGlyArgLeuLysLysProValAsp-483 493-AsnArgSerGlyGlyAspIle-499 522-TyrAlaAspGluLeuAspGlyTyrGly-530 563-SerLysIleGlySer-567 570-SerLeuProAspGlyGluGluGlyLeu-578 601-2 AMPHI Regions - AMPHI 29-AlaAlaArgGluAla-33 43-ArgValLeuGlySerPro-48 50-ProTyrGlyLysGlnIleAspGlyLeuGlyAsnAlaSerSerSer-64 94-PheValAspTrpSerGly-99 101-CysGlyAsnLeuThrAlaAla-107 134-TrpGlnLysAsnIleGlyLysThrIle-142 191-LeuValAspGluIleAspValProAsnIleGlyArg-202 210-AlaGlylleProThrValPhe-216 226-GlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluLysIleArgAlaTyr GlyAlaLeu-252 254-MetGlyLeuIleSerAspValSerGluAlaAla-264 284-SerSerGlyLysThrValAsn-290 321-AlaAlaAlaValProGlyThrLeuValAsnLeuAlaAla-333 353-GlyAlaAlaAlaGlu-357 Antigenic Index - Jameson-Wolf 11-TyrArgGlyGlyThrSerLysGlyValPhePheLysArgSerAspLeuProGluAlaAlaArgGluAlaGlyS erAlaArgAspLysIleLeu-41 46-GlySerProAspProTyrGlyLysGlnIleAspGlyLeuGlyAsnAlaSerSerSerThrSerLys-67 69-ValIleLeuAspLysSerGluArgAlaAspHisAspValAspTyr-83 89-SerIleAspLysProPhe-94 96-AspTrpSerGlyAsnCysGly-102 116-GlyLeuValAspLysGlyLysIleProSerAspGly-127 134-TrpGlnLysAsnIleGlyLysThrIle-142 155-GluThrGlyAspPheGluLeu-161 177-AspProAlaAspGlyGluGlySerMet-185 187-ProThrGlyAsnLeuValAspGluIleAspValProAsnIleGlyArgLeuLys-204 223-GlyTyrThrGlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluLysIle ArgAla-248 259-AspValSerGluAlaAlaAlaArgAlaHisThrPro-270 281-TyrThrAlaSerSerGlyLysThrValAsn-290 333-AlaGlyGlyGlyThrArgLysGluValArgPheGlyHisProSerGlyThrLeuArg-351 356-AlaGluCysGlnAspGlyGln-362 369-ValMetSerArgSerAlaArgValMet-377 382-ValArgValProGluAspCysPhe-389 Hydrophilic Regions - Hopp-Woods 22-LysArgSerAspLeuProGluAlaAlaArgGluAlaGlySerAlaArgAspLysIleLeu-41 49-AspProTyrGlyLysGlnl1eAsp-56 62-SerSerSerThrSer-66 69-ValIleLeuAspLysSerGluArgAlaAspHisAspVal-81 89-SerIleAspLysProPhe-94 116-GlyLeuValAspLysGlyLysIleProSer-125 157-GlyAspPheGluLeu-161 177-AεpProAlaAspGlyGluGly-183 191-LeuValAspGluIleAspVal-197 224-TyrThrGlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluLysIleArg Ala-248 259-AspValSerGluAlaAlaAlaArgAlaHisThr-269 283-AlaSerSerGlyLysThrValAsn-290 335-GlyGlyThrArgLysGluValArgPhe-343 356-AlaGluCysGlnAsp-360 372-ArgSerAlaArgValMet-377 384-ValProGluAspCysPhe-389 602-2 AMPHI Regions - AMPHI 21-ValAsnArgHisGlyGln-26 3 O-GlyGlyLeuAspAlaPheCys-36 54-ArgGlnIleAlaGlnIle-59 61-AlaGlyLeuHisValCysAsnSerVal-69 78-HisValIleValGluMetCysAlaTrpTyrGly-88 Antigenic Index - Jameson-Wolf 5-GlnCysAεpLysThrArgHisMetArgPro-14 19-ArgGlnValAsnArgHisGlyGlnThrGlyAsnGlyGlyLeuAspAla-34 36-CysSerLeuGlnGlyAsnArgLysAlaGlnValPheAspThrAspLeuIleAspArgGlnIle-56 90-SerAlaGlyGluTyr-94 99-GlnMetArgAspTyrIle-104 Hydrophilic Regions - Hopp-Woods 5-GlnCysAspLysThrArgHisMetArg-13 20-GlnValAsnArgHisGlyGln-26 39-GlnGlyAsnArgLysAlaGlnValPhe-47 50-AspLeuIleAspArgGlnIle-56 603-2 AMPHI Regions - AMPHI 69-MetLeuLeuAsnGluLeuGluLys-76 107-ValMetAspGluLeuAsnAlaCysIlePro-116 121-HisAsnProAlaAsnIleSerGlyIleLeuAla-131 135-HisPheProGlyLeuProAsnValGly-143 148-SerPheHisGlnThrMetPro-154 161-AlaValProArgGluLeu-166 188-GluAlaAlaArgIleLeuGlyLysProLeuGluAspIleArgMetIleIleAlaHis-206 209-AsnGlyAlaSerIleThrAlaIleLysAsnGlyLysSerVal-222 229-ThrProIleGluGly-233 248-TyrSerTyrLeuThrSer-253 273-LeuGlyIleSerGlu-277 279-SerAsnAspCysArg-283 306-ArgLeuAlaLysTyrIleAlaSerMet-314 342-ValSerTyrLeuAsp-346 Antigenic Index - Jameson-Wolf 12-GlySerSerSerLeuLysGlyAlaValIleAspArgLysSerGlySer-27 33-LeuGlyGluArgLeuThrThrProGluAla-42 45-ThrPheAsnLysAspGlyAsnLyεArgGlnValProLeuSerGlyArgAsnCysHis-63 73-GluLeuGluLysHisGlyLeuHisAspArgIleLysAlaIleGly-87 91-AlaHisGlyGlyGluLysTyrSerGlu-99 106-AlaValMetAspGluLeuAsn-112 152-ThrMetProGluArgAlaTyr-158 164-ArgGluLeuArgLysLysTyrAlaPheArgArgTyrGlyPheHisGlyThrSerMetArg-183 188-GluAlaAlaArgIleLeuGlyLysProLeuGluAspIleArg-201 207-LeuGlyAsnGlyAla-211 214-ThrAlaIleLysAsnGlyLysSerValAspThrSerMetGly-227 238-ThrArgCysGlyAspIleAspProGlyVal-247 260-AlaGlnValAspGluMetLeuAsnLysLysSerGly-271 276-SerGluLeuSerAsr_AspCysArgThrLeuGluIleAlaAlaAspGluGlyHiεGluGlyAlaArgLeu-29 8 329-GlyIleGlyGluAsnSerArgAsnIleArgAlaLysThr-341 352-IleAspThrLysAlaAsnMetGluLyεArgTyrGlyAsnSerGlyIle-367 369-SerProThrAspSerSerPro-375 381-ProThrAsnGluGluLeu-386 Hydrophilic Regions - Hopp-Woods 19-AlaValIleAspArgLysSerGly-26 33-LeuGlyGluArgLeuThrThr-39 46-PheAsnLysAspGlyAsnLysArgGlnValProLeuSerGlyArgAsnCysHis-63 73-GluLeuGluLysHisGlyLeuHisAspArgIleLysAlaIleGly-87 92-HisGlyGlyGluLysTyrSerGlu-99 106-AlaValMetAspGluLeuAsn-112 153-MetProGluArgAlaTyr-158 164-ArgGluLeuArgLysLysTyrAlaPhe-172 188-GluAlaAlaArgIleLeuGlyLysProLeuGluAspIleArg-201 217-LysAsnGlyLysSerValAspThr-224 239-ArgCysGlyAspIleAspPro-245 260-AlaGlnValAspGluMetLeuAsnLysLysSerGly-271 277-GluLeuSerAsnAspCysArgThrLeuGluIleAlaAlaAspGluGlyHisGluGlyAlaArgLeu-298 330-IleGlyGluAsnSerArgAsnIleArgAlaLysThr-341 352-IleAspThrLysAlaAsnMetGluLysArgTyrGly-363 382-ThrAsnGluGluLeu-386 604-2 AMPHI Regions - AMPHI 36-HisArgValValGlnPheAla-42 53-ValGlyGlyValHisGlyPheAlaThr-61 95-ArgThrValSerAlaAspPheLeuGluPhePhe-105 113-AspValValLeuGlnLeuPheAlaCysValAlaGlnValGlyGlyIleGlnGluAsn-131 148-ArgHisIleAsnPheIleAspGlnIleAlaGlyTrpGlu-160 166-ValGlyTrpIleLysLysPheAsp-173 191-PheGlnAsnCysAlaValLeuHisArg-199 Antigenic Index - Jameson-Wolf 11-AlaAlaCysGlyLysValAspGlnArgThrGlyTyrGlyGlyGlyGlyArgAsnGlyAsnArgGlyGlyThrH is-35 67-GlyGlyGlyArgAspGluGlyAspPheArgArgValArgAlaSerGlySerPhe-84 106-GlnSerArgGlyIle-110 127-GlyIleGlnGluAsnGlyArgAsnAlaArgValAspGluArgGlyPheGln-143 175-TyrPheGlyCysArgGluArgTyrAlaVal-184 201-MetGlyAsnAsnGly-205 211-LeuProAspPheAspArgAlaAspAlaVal-220 Hydrophilic Regions - Hopp-Woods 14-GlyLysValAspGlnArgThrGlyTyr-22 24-GlyGlyGlyArgAsnGlyAsnArgGlyGlyThrHis-35 68-GlyGlyArgAspGluGlyAspPheArgArgValArgAla-80 127-GlyIleGlnGluAsnGlyArgAsnAlaArgValAspGluArgGlyPhe-142 178-CysArgGluArgTyrAlaVal-184 213-AspPheAspArgAlaAspAlaVal-220 605 AMPHI Regions - AMPHI 13-ArgGlnIleTrpLysIleAlaAsp-20 38-ThrLeuPheTyrArgPheIleSerGluAsnPheThrAspTyrMetGln-53 107-LysLeuLysGluIlePheThrAlaIle-115 128-IleLysGlyLeuPheAspAspPheAsp-136 141-ArgLeuGlySerThr-145 155-AlaValLeuLysGlyValAlaGluLeu-163 173-IleAspLeuPheGlyAspAlaTyrGluTyrLeuIleSerAsn-186 188-AlaAlaAsnAlaGlyLys-193 204-ValSerLysLeuIleAlaArg-210 217-GluLysValAsnLysIleTyrAspPro-225 240-PheAspGluHisIle-244 291-AspSerLysProPheAspAlaIleValSerAsn-301 341-HisAlaLeuAsnTyr-345 355-ValSerPheProGly-359 433-GluHisIleAlaGluIleValLysLeuPheAla-443 452-AlaGlnAsnAlaAlaGlnGlnThr-459 478-ThrArgGluIleIleAspIle-484 489-AlaGluIleGlyGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAlaGluIle Glu-513 Antigenic Index - Jameson-Wolf 5-MetGlnGlnArgAlaGlnLeu-ll 18-IleAlaAspGluValArgGlyAlaValAspGlyTrpAsp-30 44-IleSerGluAsnPheThrAspTyrMetGlnAlaGlyAspSerSerIleAsp-60 63-AlaMetProAspSer-67 71-ProGluIleLysAspAspAlaValLysVal-80 98-AlaHisGlnAsnGluGluLeuAsnThrLysLeuLysGlu-110 116-GluSerSerAlaSerGlyTyrProSerGluGlnAspIleLysGlyLeuPheAspAspPheAspThrThrSer SerArgLeu-142 146-ValAlaAspLysAsnLysArgLeu-153 190-AsnAlaGlyLysSerGlyGlyGluPhePheThr-200 215-GlyGlnGluLysValAsnLysIleTyrAspProAlaCysGlySerGlySer-231 235-GlnAlaLysLysGlnPheAsp-241 253-GluIleAsnHisThrThrTyrAsn-260 280-LeuGlyAspThrLeuThrAsnProLysLeuLysAspSerLysProPheAsp-296 309-1leGlySerAspAspProThrLeuIleAsnAspAspArgPheAlaPro-324 330-ProLysSerLysAlaAsp-335 345-TyrLeuSerGlyArgGlyArgAlaAla-353 362-TyrArgGlyGlyAlaGluGlnLysIleArg-371 403-LeuSerLysHisLysAspAsnThrAsp-411 419-GlyPhePheLysLysGluThrAsnAsnAsnValLeuIle-431 442-PheAlaAspLysAlaAspVal-448 458-GlnThrValLysAspAsnGlyTyr-465 473-ValGluAlaGluAspThrArgGluIleIleAsp-483 490-GluIleGlyGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAla-510 Hydrophilic Regions - Hopp-Woods 5-MetGlnGlnArgAlaGlnLeu-11 18-IleAlaAspGluValArgGlyAlaValAsp-27 55-GlyAspSerSerIle-59 71-ProGluIleLysAspAspAlaValLysVal-80 98-AlaHisGlnAsnGluGluLeuAsnThrLysLeuLysGlu-110 122-TyrProSerGluGlnAspIleLysGlyLeuPheAspAspPheAspThrThrSerSerArgLeu-142 146-ValAlaAspLysAsnLysArgLeu-153 191-AlaGlyLysSerGlyGly-196 215-GlyGlnGluLysValAsnLysIleTyrAsp-224 235-GlnAlaLysLysGlnPheAsp-241 287-ProLysLeuLysAspSerLysProPhe-295 310-GlySerAspAspProThrLeuIleAsnAspAspArgPheAla-323 330-ProLysSerLysAlaAsp-335 348-GlyArgGlyArgAla-352 364-GlyGlyAlaGluGlnLysIleArg-371 404-SerLysHisLysAspAsnThrAsp-411 419-GlyPhePheLysLysGluThrAsn-426 442-PheAlaAspLysAlaAspVal-448 458-GlnThrValLysAspAsnGly-464 473-ValGluAlaGluAspThrArgGluIleIleAsp-483 490-GluIleGlyGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAla-510 606 AMPHI Regions - AMPHI 72-LeuLeuAspHisMetThrArgAspGlu-80 90-AlaHisValGlyAsnGlyAsp-96 100-LeuThrLeuIleGlnGlyValValAsnThrPhe-110 116-ArgIleIleAlaAsn-120 139-SerMetValPheGlnIleLeuPheGlyPheLeuAlaSerLeuIleVal-154 171-LysLeuValGlyAlaProLysMetIleSerAlaLeuGlnArg-184 191-AspLeuProGluGluMetAsnAla-198 Antigenic Index - Jameson-Wolf 13-GluValIleAspThrProArgThrGluGluGluAla-24 31-GluAlaGlnAlaArgGlnTrpAsnLeuLysThrProGlu-43 48-HisSerProGluProAsnAla-54 57-ThrGlyAlaSerArgAsnSerSer-64 75-HisMetThrArgAspGluValGluAla-83 92-ValGlyAsnGlyAsp-96 122-IleAlaArgAsnAsnAspGlySerGlnSerGlnGlyThr-134 159-ArgGlnArgGluTyrArgAlaAspAlaGlyAla-169 182-LeuGlnArgLeuLysGlyAsnProValAspLeuProGluGluMetAsn-197 203-GlyAspThrArgAspSerLeuLeuSerThrHisProSerLeuAspAsnArgIleAlaArgLeuLysSer-22 5 Hydrophilic Regions - Hopp-Woods 13-GluValIleAspThrProArgThrGluGluGluAla-24 59-AlaSerArgAsnSer-63 75-HisMetThrArgAspGluValGluAla-83 124-ArgAsnAsnAspGlySerGlnSer-131 159-ArgGlnArgGluTyrArgAlaAspAlaGlyAla-169 183-GlnArgLeuLysGlyAsnPro-189 191-AspLeuProGluGluMetAsn-197 203-GlyAspThrArgAspSerLeu-209 214-ProSerLeuAspAsnArgIleAlaArgLeuLysSer-225 607 AMPHI Regions - AMPHI 18-ArgLeuLeuThrThrLeuAlaLeu-25 70-PheMetGlyIleMetAlaAlaLeuAsnProMetIleAlaGln-83 90-ThrAspGluValGlyGluThr-96 104-GlyLeuPheLeuGlyValPheGlyMetValLeuMetTrpAlaAlaIleThrProPheArgAsnTrpLeuThr LeuSerAspTyrValGluGlyThrMet-136 151-MetValHisArgAlaLeuHisAlaTyrThrSerSer-162 226-PhePheArgProPheGly-231 244-PheLysGlnIleTrpLysIleGlyAla-252 320-AlaArgTyrIleSerGlyVal-326 337-IleThrValLeuSerLeuVal-343 373-PheGlnProAlaAspPheThrGlnCysIleAlaSerTyrAla-386 424-TyrGlyPheTrpThrAlaLeuIleAla-432 Antigenic Index - Jameson-Wolf 15-LysGluValArgLeu-19 47-GlyAlaGlyLysGluAspLeuAla-54 86-GlyAlaGlyLysThrAspGluValGlyGluThrGlyArgGlnGlyIle-101 121-ProPheArgAεnTrp-125 128-LeuSerAspTyrValGluGlyThr-135 160-ThrSerSerLeuAsnArgProArgLeu-168 234-AlaLysPheGlyLysProAspTrp-241 311-SerLeuGlyArgArgGluPheSerArgAlaArgTyrIleSer-324 353-TyrAsnAsnAεpPro-357 388-ArgGlyTyrLysValThrLys-394 447-LeuCysSerArgGluMetValArgSerHisLysAlaVal-459 Hydrophilic Regions - Hopp-Woods 15-LysGluValArgLeu-19 47-GlyAlaGlyLysGluAspLeuAla-54 88-GlyLysThrAspGluValGlyGluThrGlyArg-98 163-LeuAsnArgProArg-167 312-LeuGlyArgArgGluPheSerArg-319 390-TyrLysValThrLys-394 447-LeuCysSerArgGluMetValArgSerHisLysAlaVal-459 608 AMPHI Regions - AMPHI 66-AlaValGlnLysIleLeuGln-72 93-ValLeuSerLeuLeu-97 103-ArgAlaSerAspGluLeuAlaArgIlePheGlyThrGln-115 124-AspIleGlyHisGlyIleLysGlnIleGlyArgAsnIleAlaGluGlnIleGlyGlyPheSerArgGluSer GluSer-149 154-AsnGluAlaLeuAlaAspCysLeuAspGluIleSerArgLeuArgAspGlyValGluArgLeuAsnGluArg LeuAspArgLeu-181 Antigenic Index - Jameson-Wolf 13-LeuGlnSerProAspSerArgSerGluLeu-22 39-LeuAlaGlyArgIleThrGluAspGlyLeuLeuSerAlaGlyAsnGlyPheAlaAspThrGluIleThrPheA rgAεnSerAla-66 71-LeuGlnGlyGlyGluProGlyAlaGlyAεpIleGlyLeuGluGly-85 98-GlySerLeuArgSerArgAlaSerAspGluLeuAla-109 114-ThrGlnAlaAspIleGlySerArgAlaAlaAsp-124 131-GlnIleGlyArgAsnIleAla-137 140-IleGlyGlyPheSerArgGluSerGluSerAlaAsnIleGlyAsnGluAlaLeuAlaAspCysLeuAspGlu IleSerArgLeuArgAspGlyValGluArgLeuAsnGluArgLeuAspArgLeuGluArgAspIleTrp-186 Hydrophilic Regions - Hopp-Woods 15-SerProAspSerArgSerGluLeu-22 39-LeuAlaGlyArgIleThrGluAspGlyLeu-48 56-AlaAspThrGluIleThrPhe-62 74-GlyGluProGlyAlaGly-79 81-1leGlyLeuGluGly-85 100-LeuArgSerArgAlaSerAspGluLeuAla-109 116-AlaAspIleGlySerArgAlaAlaAsp-124 143-PheSerArgGluSerGluSerAlaAsnIleGly-153 156-AlaLeuAlaAspCysLeuAspGluIleSerArgLeuArgAspGlyValGluArgLeuAsnGluArgLeuAsp ArgLeuGluArgAspI1eTrp-186 609 AMPHI Regions - AMPHI 15-ThrLeuAspAlaPheVal-20 30-HisHisIlePheHisGluPheArgValPheValGlyPhePhe-43 52-PheGluGlnAlaValGlu-57 67-IleAspAspPheLeu-71 114-ValAlaValCysProVal-119 Antigenic Index - Jameson-Wolf 10-AlaLeuAspAspGluThrLeu-16 20-ValGlyAsnGlnArgSerSerAspIleAla-29 69-AspPheLeuAspThrAspPheGlyIle-77 79-SerGlnAlaAspGlyAsnValArg-86 99-GlyThrArgAlaLysArgGlyTyrGlyAsnHisAspLeu-lll 122-PheAlaArgGluThrAspIle-128 Hydrophilic Regions - Hopp-Woods 10-AlaLeuAspAspGluThrLeu-16 23-GlnArgSerSerAspIle-28 79-SerGlnAlaAspGlyAsnVal-85 100-ThrArgAlaLysArgGlyTyrGly-107 122-PheAlaArgGluThrAspIle-128 610 AMPHI Regions - AMPHI 6-MetGlnPheProTyrArg-ll 18-MetArgArgMetArgArg-23 98-GluArgAlaGlnGluAlaTyr-104 111-ProSerThrValArgAlaLeuArgGluArg-120 187-IleArgGluAlaLeuGlu-192 208-TyrAlaSerAlaPheTyrGlyProPheArgAsp-218 223-SerGlyAsnLeuGlyLysAlaAsp-230 268-LeuAspValValArgArgValLysAspGlu-277 296-AlaAlaIleAlaAsn-300 Antigenic Index - Jameson-Wolf 11-ArgAsnValProAlaSerArgMetArgArgMetArgArgAspAεpPheSerArgArgLeuMetArgGluHiεT hrLeuThrAlaAεpAsp-40 50-GlySerAlaArgGluGluAspValProSerMetProGlyValLysArgGlnSerLeuAsp-69 75-AlaGluGluAlaValLys-80 94-AlaAsnLysThrGluArgAlaGlnGluAlaTyrAsnProGluGlyLeuVal-110 115-ArgAlaLeuArgGluArgPhePro-122 139-GlyGlnAspGlyLeuThrAspGluAsnGlyTyrValMetAsnAspGluThrVal-156 175-AlaProSerAspMetMetAspGlyArgIleGlyAlaIleArgGluAlaLeuGluAspAlaGlyHis-196 215-ProPheArgAspAlaValGlySerSerGlyAsnLeuGlyLyεAlaAspLysLysThrTyrGlnMetAspPro AlaAsnThrAspGluAlaLeuHis-246 250-LeuAspIleGlnGluGlyAlaAsp-257 270-ValValArgArgValLysAspGluPheGlyVal-280 301-GlyTrpLeuAspGlyGlyLysValVal-309 317-LysArgAlaGlyAlaAspGly-323 331-GluAlaAlaLysMetLeuLysArg-338 Hydrophilic Regions - Hopp-Woods 14-ProAlaSerArgMetArgArgMetArgArgAspAspPheSerArgArgLeuMetArgGluHisThrLeuThrA la-38 50-GlySerAlaArgGluGluAspValProSer-59 61-ProGlyValLysArgGlnSerLeuAsp-69 75-AlaGluGluAlaValLys-80 95-AsnLysThrGluArgAlaGlnGluAlaTyrAsn-105 115-ArgAlaLeuArgGluArgPhePro-122 141-AspGlyLeuThrAspGluAsnGly-148 151-MetAsnAspGluThrVal-156 178-AspMetMetAspGlyArgIleGlyAlaIleArgGluAlaLeuGluAspAlaGly-195 216-PheArgAspAlaValGly-221 225-AsnLeuGlyLysAlaAspLysLysThrTyrGln-235 238-ProAlaAsnThrAspGluAlaLeuHis-246 250-LeuAspIleGlnGluGlyAlaAsp-257 270-ValValArgArgValLysAspGluPheGly-279 317-LysArgAlaGlyAla-321 331-GluAlaAlaLysMetLeuLysArg-338 611 AMPHI Regions - AMPHI 15-CysArgLeuPheGlyLysLeuSerLeu-23 26-ArgLeuLeuLeuGlyLeu-31 48-ArgSerValArgArgValIle-54 63-GlnValValAlaVal-67 104-ValPheIleGluAspPheVal-110 130-GlyPheLeuGlyAsnValLeuArgThr-138 Antigenic Index - Jameson-Wolf l-MetProSerGluAsnGlyMetGlyLysArgGlnLeuAla-13 32-CysArgSerGlyValCysArgGlyArgCys-41 45-PheProSerArgSerValArgArgValIlePheArgArgValArgIle-60 119-AsnProAlaAspPheArgVal-125 142-AlaSerGlnGluAsp-146 Hydrophilic Regions - Hopp-Woods l-MetProSerGluAsnGlyMetGlyLysArgGlnLeuAla-13 35-GlyValCysArgGlyArgCys-41 53-ValIlePheArgArgValArgIle-60 121-AlaAspPheArgVal-125 142-AlaSerGlnGluAsp-146 612-2 AMPHI Regions - AMPHI 6-AsnIleAlaLysLysLeuAlaGlyValAsp-15 57-LysAlaValGluLysCysAlaGluAsnValLeu-67 81-GlyAsnPheProAsn-85 Antigenic Index - Jameson-Wolf 7-IleAlaLysLysLeuAlaGlyValAsp-15 27-AspPheGlyArgAspAspAlaValArgHisSerGlyVal-39 57-LysAlaValGluLysCysAlaGlu-64 97-GlyHisHisArgAsnProTyrLysSer-105 Hydrophilic Regions - Hopp-Woods 7-IleAlaLysLysLeuAlaGlyValAsp-15 28-PheGlyArgAspAspAlaValArg-35 57-LysAlaValGluLysCysAlaGlu-64 101-AsnProTyrLysSer-105 613-2 AMPHI Regions - AMPHI 7-SerArgArgSerLeu-ll 95-MetProArgMetArgSer-100 103-SerProMetSerProAla-108 115-ArgllePheCysThrAlaLeuLeuArgLys-124 140-SerSerValMetArgProAla-146 168-LeuSerGlyLeuCysArgIle-174 Antigenic Index - Jameson-Wolf l-MetSerArgSerSerArgSerArgArgSerLeuArgArgSerThrProSerArg-18 23-SerSerArgGlnSerAlaArgAla-30 35-PheAlaAspSerAspSerArgGluAsnProProIleCysSer-48 73-ProLysIleArgAlaAsnSerSerAspAlaArgGluArgArgLeuProSerArgAspSerThrAla-94 96-ProArgMetArgSerProSerSerProMetSerProAlaProGlySerProProTrp-114 130-AlaLysProPheProAlaGluSerLysProSerSerValMetArgProAlaSer-147 162-AlaAlaSerSerGluArgLeuSerGlyLeuCysArgIleArgArg-176 178-MetMetGlyArgArgAlaAspIlePheSerAspArgGlyGlyGlu-192 205-LeuSerArgTyrArgLysArgTyrGly-213 Hydrophilic Regions - Hopp-Woods l-MetSerArgSerSerArgSerArgArgSerLeuArgArgSerThrProSer-17 24-SerArgGlnSerAlaArgAla-30 36-AlaAspSerAspSerArgGluAsnProPro-45 73-ProLysIleArgAlaAsnSerSerAspAlaArgGluArgArgLeuProSerArgAspSerThrAla-94 96-ProArgMetArgSerProSer-102 133-PheProAlaGluSerLysProSerSerValMetArg-144 162-AlaAlaSerSerGluArgLeuSerGly-170 172-CysArgIleArgArg-176 178-MetMetGlyArgArgAlaAspIlePheSerAspArgGlyGlyGlu-192 206-SerArgTyrArgLysArgTyrGly-213 614-2 AMPHI Regions - AMPHI 20-SerGlnPheIleGlnGlnVal-26 65-AεnLeuIleLysThrLeuLeuAsp-72 90-AlaLeuPheTyrSerLeuLeuProValLeu-99 144-ValAlaGlyCysAspGluAlaLysGluGluValGlnGluIleValAspTyrLeuLysAlaProAsnArgTyr GlnSerLeu-170 210-AspPheValGluMetPheVal-216 222-ArgValArgAspMetPheGluGln-229 242-GluIleAspAlaValGlyArg-248 295-ProAlaLeuGlnArgProGlyArgPheAsp-304 333-SerValAspLeuLeuSerLeuAla-340 349-AlaAspLeuAlaAsnLeuValAsn-356 478-SerAsnAspPheGluArgAlaThrGlnMet-487 526-SerGluLysThrGln-530 536-GluIleArgArgIleLeuAsp-542 561-ThrMetCysLysAlaLeuMetGluTrpGluThr-571 591-AspTyrSerHisAsn-595 619-ProAlaProAlaAspThr-624 Antigenic Index - Jameson-Wolf 7-LeuAspGlyLysLysGluAspAsnGlyGlnIleGlu-18 26-ValAsnAsnGlyGluValSerGly-33 45-LeulleLysGlyGluArgThrAspLysSerThrPhe-56 60-AlaProLeuAspAspAsnLeuIle-67 70-LeuLeuAspLysAsnValArgValLysValThrProGluGluLysProSerAla-87 lll-MetGlnThrGlyGlyGlyGlyLysGlyGly-120 123-SerPheGlyLysSerArgAlaArgLeuLeuAspLysAspAlaAsnLys-138 145-AlaGlyCysAspGluAlaLysGluGluValGlnGlu-156 161-LeuLysAlaProAsnArgTyrGlnSerLeuGlyGlyArgValProArgGly-177 182-GlySerProGlyThrGlyLysThrLeuLeu-191 207-SerGlySerAspPhe-211 219-GlyAlaSerArgValArgAspMetPheGluGlnAlaLysLysAsnAla-234 241-AspGluIleAspAlaValGlyArgGlnArgGlyAlaGlyLeuGlyGlyGlyAsnAspGluArgGluGlnThr Leu-265 272-MetAspGlyPheGluSerAsnGln-279 287-ThrAsnArgProAspValLeuAspProAlaLeuGlnArgProGlyArgPheAspArg-305 311-LeuProAspIleArgGlyArgGluGlnIle-320 323-ValHisSerLysLysValProLeuAspGluSerValAsp-335 341-ArgGlyThrProGlyPheSerGly-348 362-AlaGlyArgArgAsnLysValLysValAspGlnSerAspPheGluAspAlaLysAspLysIleTyrMetGly ProGluArgArgSerMetValMetHisGluAspGluLysArgAlaThrAla-402 425-ThrIleMetProArgGlyArgAla-432 438-GlnLeuProGluArgAspArgIleSerMetTyrLysAspGlnMet-452 460-PheGlyGlyArgIleAlaGlu-466 474-SerThrGlyAlaSerAsnAspPheGluArgAlaThrGlnMetAlaArgGluMetValThr-493 495-TyrGlyMetSerAspLysMetGly-502 507-AlaGluAsnGluGlyGluValPheLeu-515 518-SerValThrArgSerGlnAsnIleSerGluLysThrGlnGlnAspIleAspAlaGluIleArgArgIleLeu AspGluGlnTyr-545 551-11eLeuAspGluAsnArgAspLysMetGluThrMetCys-563 570-GluThrIleAspArgAspGlnVal-577 581-MetAlaGlyLysGlnProSerProProLysAspTyrSerHisAsnLeuArgGluAsnAlaAspAlaAlaGlu AspAsnAlaProHisAlaProThrArgGluGluThrGluAlaProAlaProAlaAspThrAlaSerThrGluSerG luGlnGlnProGluAsnLysAla-637 Hydrophilic Regions - Hopp-Woods 7-LeuAspGlyLysLysGluAspAsnGlyGln-16 27-AsnAsnGlyGluValSer-32 46-1leLysGlyGluArgThrAspLysSerThr-55 61-ProLeuAspAspAsnLeuIle-67 70-LeuLeuAspLysAsnValArgValLysValThrProGluGluLysProSerAla-87 115-GlyGlyGlyLysGlyGly-120 125-GlyLysSerArgAlaArgLeuLeuAspLysAspAlaAsnLys-138 145-AlaGlyCysAspGluAlaLysGluGluValGlnGlu-156 162-LysAlaProAsnArg-166 171-GlyGlyArgValProArg-176 221-SerArgValArgAspMetPheGluGlnAlaLysLysAsnAla-234 241-AspGluIleAspAlaValGlyArgGlnArgGlyAlaGly-253 256-GlyGlyAsnAspGluArgGluGlnThr-264 273-AspGlyPheGluSer-277 287-ThrAsnArgProAspValLeuAsp-294 296-AlaLeuGlnArgProGlyArgPheAspArg-305 312-ProAspIleArgGlyArgGluGlnIle-320 324-HisSerLysLysValProLeuAspGluSerValAsp-335 362-AlaGlyArgArgAsnLysValLysValAspGlnSerAspPheGluAspAlaLysAspLysIleTyrMetGly ProGluArgArgSerMetValMetHisGluAspGluLysArgAlaThrAla-402 428-ProArgGlyArgAla-432 439-LeuProGluArgAspArgIleSerMetTyrLys-449 477-AlaSerAsnAspPheGluArgAlaThrGlnMetAlaArgGluMetValThr-493 496-GlyMetSerAspLysMetGly-502 507-AlaGluAsnGluGlyGluValPheLeu-515 518-SerValThrArgSerGlnAsnIleSerGluLysThrGlnGlnAspIleAspAlaGluIleArgArgIleLeu AspGluGlnTyr-545 551-IleLeuAspGluAsnArgAspLysMetGluThrMetCys-563 570-GluThrIleAspArgAspGlnVal-577 584-LysGlnProSerProProLysAspTyrSerHisAsnLeuArgGluAsnAlaAspAlaAlaGluAspAsnAla Pro-608 610-AlaProThrArgGluGluThrGluAlaProAlaProAlaAspThrAlaSerThrGluSerGluGlnGlnPro GluAsnLysAla-637 616-2 AMPHI Regions - AMPHI 6-LysMetValValGlyLeu-ll 13-AsnProGlyLysGluTyrGlu-19 48-PheGlyGluValAlaArgAla-54 77-ValAlaAlaLeuAlaGlnPheTyrLys-85 115-GlyHisAsnGlyLeuLysAspIle-122 159-HisArgArgGlnIleAspAspAlaValAlaLysSerLeuGlnAlaIleProAspIleLeuAlaGlyLysTrp GluGluAlaThrArgPheLeuHisSer-191 Antigenic Index - Jameson-Wolf ll-LeuGlyAsnProGlyLysGluTyrGluGlnThrArgHisAsnAlaGlyPhe-27 39-AlaSerPheLysGluGluLysLysPhePhe-48 55-AlaLeuProAspGly-59 70-MetAsnArgSerGlyGlnAla-76 86-IleLysProGluGlu 96-AspGluLeuAspIleProCysGlyArgIleLysPhe-107 109-LeuGlyGlyGlyAsnGlyGlyHisAsnGlyLeuLysAspIleGlnAla-124 127-GlyThrAlaAspTyrTyrArg-133 138-IleGlyHisProGlyAspArgAsnLeu-146 152-LeuAsnLysProSerThrGluHisArgArgGlnIleAspAspAlaValAla-168 181-LysTrpGluGluAlaThrArg-187 Hydrophilic Regions - Hopp-Woods 13-AsnProGlyLysGluTyrGluGlnThrArgHiε-23 39-AlaSerPheLyεGluGluLysLysPhePhe-48 86-IleLysProGluGlu-90 96-AspGluLeuAspIleProCysGlyArgIleLysPhe-107 117-AsnGlyLeuLysAspIleGlnAla-124 140-HisProGlyAspArgAsnLeu-146 155-ProSerThrGluHisArgArgGlnIleAspAspAlaValAla-168 181-LysTrpGluGluAlaThrArg-187 619 AMPHI Regions - AMPHI 50-LysLeuAlaAlaLeuLeu-55 66-GlnLeuPheGlnThrLeuThrAsn-73 134-GlnGlyGlyArgAspLeu-139 146-GlyValIlePheGlyIleLeuPheArgSerLeuSerSerLeuLeuSerArg-162 165-AspProGluGluPhe-169 175-AsnMetPheAlaGlyPheAsnThrValHisSer-185 246-AlaValValGlyProValSerPhePheGlyLeuLeuAlaAlaSerLeuAlaAsnHisPheSer-266 294-GluHisLeuLeuGly-298 303 -LeuSerValValValGluPhe-309 Antigenic Index - Jameson-Wolf l-MetProSerGluLysAsnIle-7 ll-AlaGlySerSerArgPro-16 35-AsnValLysGlyAspTrpAsp-41 132-IleLysGlnGlyGlyArgAspLeuSer-140 163-MetIleAspProGluGluPheThr-170 203-TrpArgGluArgTyrArgLeuAsp-210 215-GlyArgAspGlnAlaVal-220 265-PheSerProSerValLysHisSerVal-273 Hydrophilic Regions - Hopp-Woods l-MetProSerGluLysAsnIle-7 134-GlnGlyGlyArgAspLeuSer-140 163-MetIleAspProGluGluPheThr-170 203-TrpArgGluArgTyrArgLeu-209 215-GlyArgAspGlnAla-219 269-ValLysHisSerVal-273 620 AMPHI Regions - AMPHI 9-ValAlaValSerAlaLeuSerAlaCysArgGlnAla-20 31-IleSerAspArgSerVal-36 67-SerThrIleLysGlnMetPheGlyTyrThrLysLeuProGluGluProLysGlyIleArgValIleTyrValT hrAspMetGlyAsnValThrAspTrpThr-100 139-GlnAlaGluLysPhe-143 Antigenic Index - Jameson-Wolf 15-SerAlaCysArgGlnAlaGluGluGlyProProProLeuProArgGlnIleSerAspArgSerValGlyHis- 38 43-AsnLeuThrGluHisAsnGlyProLysAla-52 57-AsnGlyLysProAspGlnProVal-64 75-TyrThrLyεLeuProGluGluProLyεGlyIle-85 97-ThrAspTrpThrAsnProAsnAlaAspThrGluTrpMetAspAlaLysLys-113 125-GlyMetGlyAlaGluAspAlaLeuProPheGlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGly GlyLysValValGlyPheAspAspMetProAspThrTyr-161 Hydrophilic Regions - Hopp-Woods 18-ArgGlnAlaGluGluGlyProProProLeu-27 30-GlnIleSerAspArgSerVal-36 46-GluHisAsnGlyProLys-51 58-GlyLysProAspGln-62 77-LysLeuProGluGluProLysGlyIle-85 103-AsnAlaAspThrGluTrpMetAspAlaLysLys-113 127-GlyAlaGluAspAlaLeu-132 135-GlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGlyGlyLys-150 155-AspAspMetProAsp-159 622 AMPHI Regions - AMPHI 28-LeuProLysAlaValArgAsnLeuAlaArg-37 62-GluGluIleIleArgTrpLeuAlaAsp-70 112-IleLeuGlyGlnIleLysAspAlaValArgValAlaGln-124 131-LysLysLeuAsnAlaLeuPheGlnLys-139 142-SerValAlaLysGluVal-147 169-GluGlnIlePheProAspIleGlyAsp-177 187-GluMetIleGluLeuValAla-193 214-AlaGlnGluLeuCysAspLys-220 232-AspLeuProAlaIleLeuHis-238 288-AspLeuAsnAspAla-292 297-ValAspAspMetValAsnIleValGlnSerGly-307 324-GluLysValAlaGluPheValArgGlnGln-333 345-LeuArgAspGluGlyGluLys-351 354-LysGlnValLeuGluAsnAlaMetLysGlnLeuAlaLys-366 372-GluValLeuGluArgLeuSerValGlnLeuThr-382 384-LysLeuLeuHisSerProThrGlnThrLeuAsnLysAlaGlyGlu-398 Antigenic Index - Jameson-Wolf 16-SerIleArgGluLysLeuAla-22 30-LysAlaValArgAsnLeuAlaArgSerAsnAlaAla-41 49-ThrCysAsnArgThrGlu-54 57-CysValGlyAspSerGluGluIleIle-65 75-ProIleGluGluIleArgPro-81 87-AspMetGlnGluThrValArgHis-94 115-GlnIleLysAspAlaValArgValAlaGlnGluGlnGluSerMetGlyLysLysLeu-133 142-SerValAlaLysGluValArgThrAspThrAlaValGlyGluAsnSerVal-158 174-AspIleGlyAspLeuAsn-179 199-LysSerProArgLeu-203 210-ThrLeuAlaArgAlaGlnGluLeuCysAspLysLeuGlyValAsnAlaGlu-226 257-GlyMetValGluArgAlaLeuLysGlnArgGlnSer-268 277-AlaValProArgAspIleGluAlaGluValGlyAspLeuAsnAsp-291 305-GlnSerGlyLysGluAlaArgGlnLysAlaAlaAlaAla-317 321-LeuValSerGluLysValAlaGluPheValArgGlnGlnGlnGlyArgGlnSerVal-339 343-LysAlaLeuArgAspGluGlyGluLysAlaArgLysGlnValLeu-357 368-AlaThrAlaGluGluValLeuGlu-375 381-LeuThrAsnLysLeuLeuHisSerProThrGlnThrLeuAεnLysAlaGlyGluGluAspLysAspLeuVal -404 Hydrophilic Regions - Hopp-Woods 16-SerIleArgGluLysLeuAla-22 30-LysAlaValArgAsnLeuAlaArgSerAsnAlaAla-41 59-GlyAspSerGluGluIleIle-65 75-ProIleGluGluIleArg-80 87-AspMetGlnGluThrValArgHis-94 115-GlnIleLysAspAlaValArgValAlaGlnGluGlnGluSerMetGlyLysLysLeu-133 142-SerValAlaLysGluValArgThrAspThrAlaValGlyGluAsnSerVal-158 210-ThrLeuAlaArgAlaGlnGluLeuCysAsp-219 257-GlyMetValGluArgAlaLeuLysGlnArgGlnSer-268 277-AlaValProArgAspIleGluAlaGluValGlyAspLeuAsn-290 305-GlnSerGlyLysGluAlaArgGlnLysAlaAlaAlaAla-317 321-LeuValSerGluLysValAlaGluPheValArg-331 333-GlnGlnGlyArgGlnSer-338 343-LysAlaLeuArgAspGluGlyGluLyεAlaArgLysGlnValLeu-357 368-AlaThrAlaGluGluValLeuGlu-375 392-ThrLeuAsnLysAlaGlyGluGluAspLysAspLeuVal-404 624 AMPHI Regions - AMPHI 14-LeuLeuLeuGlyIleIleGlyIlePheLeuPro-24 45-ArgPheTyrArgTrpLeuHisArg-52 58-ProMetValHisAsn-62 92-PheProGlnArgTrpTrpValGlyAla-100 102-SerSerValPheCysSerLeuValAlaIle-lll Antigenic Index - Jameson-Wolf 41-LysAlaSerProArgPheTyr-47 50-LeuHisArgHisArgTyrPheGlyPro-58 63-TrpGluGlnAsnGlyAlaValProArgLysAlaLys-74 115-ArgArgProGluSer-119 Hydrophilic Regions - Hopp-Woods 67-GlyAlaValProArgLysAlaLys-74 115-ArgArgProGluSer-119 625 AMPHI Regions - AMPHI 25-SerGlyArgIleIleSerIleAlaAla-33 64-LysMetProProGluMetValTyrArgAla-73 Antigenic Index - Jameson-Wolf 5-ArgLysMetLysLysMetThrMetCysThrArgArgVal-17 57-ProPheLysSerProGlnThrLysMetProPro-67 73-AlaSerSerSerArgMetLysGly-80 96-AspAlaProLysThrLysLeuAsnGlyMetArgLysSerAsnValGln-lll Hydrophilic Regions - Hopp-Woods 5-ArgLysMetLysLysMetThrMetCysThrArgArgVal-17 60-SerProGlnThrLyεMetProPro-67 74-SerSerSerArgMetLysGly-80 96-AspAlaProLysThrLysLeuAsnGlyMetArgLysSerAsnValGln-lll 627-2 AMPHI Regions - AMPHI 52-TrpHisHisHisTyrGlyLysIleThrAlaPheTrpThrLeuLeuPheLeu-68 83-ThrValAlaHisAlaLeu-88 128-ValGlyThrAlaLeuAlaSerIleMetGly-137 173-IleGlyGlyGlyLeuThrPro-179 189-PheLeuLysGlyValAsp-194 245-AlaIlePheGlyLysTrp-250 258-ValValGlyAlaVal-262 284-LeuGlnAsnLeuVal-288 319-IleAlaGluValGlyLysLeuPheLeuGlyIlePheIleThrIlePheProValLeuSerIleLeuLysAla GlyGluAlaGlyAlaLeuGlyGlyValValSerLeuValHisAspThrAlaGlyHisProIle-363 372-GlyIleLeuSerAlaPheLeuAspAsnAla-381 404-PheHisSerLeuLeuAlaValSer-411 416-PheMetGlyAlaLeuThrTyrIleGlyAsnAlaProAsnPheMetValLys-432 444-ThrPhePheGlyTyr-448 Antigenic Index - Jameson-Wolf 20-AspLeuAspGlyAlaAsn-25 114-AspLeuAsnGlyThrProLysLeu-121 149-LeuLeuLysAlaAsnGlnAsnArgThrArgArgVal-160 172-AεnIleGlyGlyGly-176 178-ThrProLeuGlyAspProPro-184 223-ArgPhePheLysGlnGluSerIleAlaGlnAspThrProAlaGlnGlnGluLysProGluLys-243 266-GlyLeuTrpLysProGluHisProGlyPhe-275 304-ThrProLysGlnValArgAlaGlyAsnGluPheAsnPhe-316 357-AspThrAlaGlyHis-361 391-AlaGlyGlyAspAla-395 433-AlaIleAlaGluGlnArgGlyValPro-441 Hydrophilic Regions - Hopp-Woods 153-AsnGlnAsnArgThrArgArgVal-160 228-GluSerIleAlaGln-232 234-ThrProAlaGlnGlnGluLysProGluLys-243 268-TrpLysProGluHisProGly-274 306-LysGlnValArgAlaGlyAsn-312 433-AlaIleAlaGluGlnArgGlyVal-440 628 AMPHI Regions - AMPHI 10-CysGlyProProAsnSerCysValSerMetLeuAlaAlaPheSerAspGlyThrSerAlaProAlaAla-32 34-GlnThrTrpIleLeuArgSer-40 Antigenic Index - Jameson-Wolf 6-LysProAlaGlyCysGlyProProAsnSer-15 23-PheSerAspGlyThrSerAla-29 40-SerValLysArgLeuAsnThrAsnArgProArgLeuLysSerSerAla-55 77-MetAlaAsnGlySerAlaSerThr-84 91-GlyArgValArgSerAlaValHisLysProAspTrpIleArgLeuArgArgThrSerSerProLeuLys-113 Hydrophilic Regions - Hopp-Woods 40-SerValLysArgLeuAsnThrAsnArgProArgLeuLysSerSerAla-55 91-GlyArgValArgSerAlaValHisLys-99 101-AspTrpI1eArgLeuArgArgThrSerSer-110 629 AMPHI Regions - AMPHI 32-ArgTrpSerAspValPheSer-38 48-IleSerArgLeuProArgThrPhe-55 116-ValAlaAlaLeuIleGlyMetLeu-123 146-IlePheGlyGlyValIleGluAlaValAlaThr-156 167-MetLeuGlyValTrpGlnGlnGlyAsp-175 206-IleLeuGlyLeuGlyGlu-211 252-ValValProAsnIleIleSerArgLeuMetGlyAspArgLeuArgGlnSer-268 285-IleIleGlyArgVal-289 300-ThrValPheGlyValLeu-305 Antigenic Index - Jameson-Wolf 38-SerLeuSerAspSerGln-43 50-ArgLeuProArgThr-54 77-AsnArgPheValGluProSerMetValGlyAlaSerGln-89 130-ArgArgLeuProProThrAla-136 260-LeuMetGlyAspArgLeuArgGlnSer-268 Hydrophilic Regions - Hopp-Woods 260-LeuMetGlyAspArgLeuArgGln-267 630-2 AMPHI Regions - AMPHI 6-PheLeuGluLysIleGluPro-12 23-TrpTyrAlaLeuTyrGlu-28 64-LeuPheProAlaMetPheTyrGlyMetTyrAsn-74 87-LeuLeuGlnGlnAsnIleAlaAsnAspTrpHisTyrAlaPhe-100 137-GlyPheTrpGluValLeuPheAla-144 190-PheGlyGlyThrGlyLysAsnPhe-197 224-AlaValAspGlyTyrSerGlyAlaThrAlaLeuAlaGlnTrp-237 242-AlaAspGlyLeuLysAsnAlaVal-249 258-AspAlaPheIleGlyLysLeuProGlySerIleGlyGluValSer-272 285-PheAlaArgIleAlaSerTrpArgIleIleAlaGlyValMet-298 302-IleAlaMetSerSerLeuPheAsnPhe-310 344-ValSerAlaSerPheThrAsnValGlyLysTrpTrpTyrGlyAlaLeuIleGlyValMetCysValLeuIle ArgVal-369 382-IleLeuPheAlaAsnLeuPheAlaProIlePheAspTyrPhe-395 Antigenic Index - Jameson-Wolf 6-PheLeuGluLysIleGlu-ll 16-ProGlyGlyLysHisGluLys-22 37-SerGlyAlaValThrArgLysAlaAlaHisValArgAspAlaLeuAspSerLysArgMet-56 107-AsnMetSerSerGluAlaGlyValSerAspLysMet-118 146-ValArgLysHisGluIleAsnGlu-153 189-ValPheGlyGlyThrGlyLysAεnPheMet-198 212-TyrProAlaAsnLeuSerGlyAspAla-220 241-GlyAlaAspGlyLeuLys-246 264-LeuProGlySerIleGly-269 312-GlySerAspThrAsnAla-317 400-AsnIleLysArgArgLysAlaArgSerAsnGly-410 Hydrophilic Regions - Hopp-Woods 6-PheLeuGluLysIleGlu-ll 18-GlyLysHisGluLys-22 39-AlaValThrArgLysAlaAlaHisValArgAspAlaLeuAspSerLysArgMet-56 108-MetSerSerGluAlaGlyValSerAsp-116 146-ValArgLysHisGluIleAsn-152 400-Asnl1eLysArgArgLysAlaArgSerAsnGly-410 638 AMPHI Regions - AMPHI 30-IleValAspIleValGluHis-36 46-AspIleValGluTyrPheGluProLeuGlyLys-56 108-ProPheGlyAsnValValAlaAspAspLeuArgThrGly-120 148-ArgIleGlyArgThrMet-153 198-GluArgTyrValArgArgValTyrGlyTyrGlyThrPro-210 212-ProValAlaPheAspGlyCysGlyThrValGlyArg-223 242-SerGlnPheGluArgIleAlaArgProGly-251 Antigenic Index - Jameson-Wolf 43-AlaAspGlyAspIle-47 53-ProLeuGlyLysHisGln-58 81-ValAspGlyGluThrGlnIle-87 99-AlaGlyIleGlyLysAsnAlaVal-106 113-ValAlaAspAspLeuArgThrGlyCysValProAsnGly-125 135-GlnSerArgValAlaAsp-140 156-TyrAlaAspArgIleIle-161 168-AsnGlnGlyAlaArgGlySerPhe-175 178-IleAsnThrGlyIleHis-183 188-HisThrGlyThrGlyAsnGlyGlnValAlaGluArgTyrValArg-202 205-TyrGlyTyrGlyThr-209 216-AspGlyCysGlyThrValGlyArgProPheAsnArgAsnArgPheVal-231 240-AlaGlySerGlnPheGluArgIleAlaArgProGlyAlaGlyLysCysGly-256 Hydrophilic Regions - Hopp-Woods 43-AlaAspGlyAspIle-47 81-ValAspGlyGluThrGlnIle-87 113-ValAlaAspAspLeuArgThr-119 136-SerArgValAlaAsp-140 195-GlnValAlaGluArgTyrValArg-202 243-GlnPheGluArgIleAlaArgProGlyAlaGly-253 639-1 AMPHI Regions - AMPHI 95-TyrLysAsnAsnArg-99 137-LeuLysValPheAspAsnIle-143 157-ValAsnTyrSerAspIleHisAspAsnIleIleAsnLysAla-170 181-TyrAspLysLeuPheAlaAsnHisPheGlu-190 269-AlaProValSerArg-273 290-GlnPheProAlaValLeuProGly-297 322-AspGluLeuLeuLysGluValGlu-329 Antigenic Index - Jameson-Wolf 13-GluGluThrAlaPro-17 23-HisAsnAsnIleLeuAspAsnSer30 41-AlaMetValArgGluAsnLysIleValGly-50 52-AlaThrLeuArgValAsnGluArgGlyAsnGly-62 75-GlyAsnAspIleSerLysGlyArgAspGlyIlePheSerAsnThrSerThrHisAsnThrTyrLysAεnAsnA rgPheSerAsp-102 lll-TyrThrAsnAspSerGluIleSerGly-119 121-IleSerValGlyAsnAsn-126 135-GluArgLeuLysVal-139 145-ValGlySerArgAspGlnGlyIle-152 160-SerAspIleHisAspAsnIleIleAsnLysAlaGlyLys-172 203-GluGlyThrSerLeuHisAspAsnSerPheIleAsnAsnGluSerGlnValLysTyrVal-222 228-AspTrpSerGluGlyGlyHisGlyAsnTyrTrpSerAspAsnSerAla-243 246-LeuAsnGlyAspGlyPheGlyAspSerAlaTyrArgProAsnGlyIleIle-262 297-GlyGlyValValAspSerLysProLeuMetLysProTyrAlaProLysIleGlnThr-315 318-GlnAlaMetLysAspGluLeuLeuLysGluValGluThrArgGlnSerGluTrpGlyArgAlaGluAsnGly SerLeuAsn-344 Hydrophilic Regions - Hopp-Woods 41-AlaMetValArgGluAsnLysIleValGly-50 52-AlaThrLeuArgValAsnGluArgGlyAsn-61 77-AspIleSerLyεGlyArgAspGlyIle-85 95-TyrLysAsnAsnArgPheSerAsp-102 113-AsnAspSerGluIleSerGly-119 135-GluArgLeuLysVal-139 146-GlySerArgAspGlnGly-151 299-ValValAspSerLysProLeuMet-306 318-GlnAlaMetLysAspGluLeuLeuLysGluValGluThrArgGlnSerGluTrpGlyArgAlaGluAsnGly Ser-342 640-2 AMPHI Regions - AMPHI 6-SerIleLeuLysSerIleGlyIle-13 22-SerIleLysArgMetSer-27 47-LeuProAlaTyrAlaGluArgLeuProAspPheLeuAlaLysIleGlnPro-63 72-ArgTyrGlyLysPro-76 127-AlaLysLeuValAspHisHis-133 141-IleProHisLeuProAlaProGlyArgAlaIle-151 153-SerAsnTrpLeuProAla-158 Antigenic Index - Jameson-Wolf 24-LysArgMetSerAlaPheArgAlaArgIle-33 50-TyrAlaGluArgLeuProAspPhe-57 59-AlaLysIleGlnProSerGluIlePheProGlyAlaAspArgTyrGlyLysProGluGlyLysProMetVal- 82 84-ArgValTyrLysGlyAspGluGlnLeu-92 101-AlaValAsnThrArgGlyTyrSerSerLysProIleAsp-113 128-LysLeuValAspHisHisGlu-134 144-LeuProAlaProGlyArgAlaIleArg-152 168-AsnArgLeuArgLeuLysGlyLeuPro-176 178-ValProGlnProSerLysAlaThrGly-186 Hydrophilic Regions - Hopp-Woods 24-LysArgMetSerAlaPheArgAlaArgIle-33 50-TyrAlaGluArgLeuPro-55 68-ProGlyAlaAspArgTyrGlyLysProGluGlyLysProMetVal-82 85-ValTyrLysGlyAspGluGlnLeu-92 128-LysLeuValAspHisHisGlu-134 146-AlaProGlyArgAlaIleArg-152 168-AsnArgLeuArgLeuLysGly-174 180-GlnProSerLysAlaThrGly-186 642-2 AMPHI Regions - AMPHI 157-IleLysHisIleValArgAlaPhe-164 179-GlyValSerAlaPheLysThrLeuArgThrGlnGluPheLeuGlnHisLeuArgGlyGlyVal-199 202-PheArgGlyGluGly-206 208-AspAspValArgLeu-212 228-AspValAlaValLysAsnLeuGlyAsnLeuMetAlaAlaProAsp-242 259-PheGlnIlePheLysAspValPheHisAsnAlaValArgHisAlaAspGlnLeuGln-277 311-ValAspGlyValThrAspGlyAla-318 337-GlnValAspAspPheGlyGluPheAlaValPhe-347 366-PheArgGlyValAsp-370 409-HisLeuGlnThrLeuArgAspLeuArgPheIleAlaGluLeuLeuGlnTrpLeuGlnHisGlnArgAlaPhe AspAlaGlyThr-436 445-ProArgAsnProGlnAsp-450 Antigenic Index - Jameson-Wolf 1-MetArgHisProProGlnSerAlaAlaLeu-lO 17-LeuLeuHisArgProLysSerValCysArgArgArgLysCysArgLeuLysAla-34 36-ProLeuSerAspGlyIleAlaCys-43 63-ValGlnGlnGluGlyCysGly-69 75-LeuTyrGluAspLysGluSerGlyAspAspPheAlaAspLysAspPheLeuGln-92 104-GluAlaAlaAspValPheArg-llO 115-AlaGlyAspGlyGlyLysAlaGly-122 144-PheGlyGlyGlyAlaAspLysLeu-151 164-PheLysAsnArgGluGlyAlaAspValAspSerAspIleAlaGly-178 184-LysThrLeuArgThrGlnGlul-190 202-PheArgGlyGluGlyPheAspAspValArgLeu-212 217-GlyAspGlyGlyAsnArgArgAsnGlyMetAla-227 249-AspGluPheAspVal-253 271-ArgHiεAlaAspGlnLeuGlnAlaAlaAlaAspLysAspValLeuGluArgAlaGlnThrGly-291 300-HisGlyGlyCysArg-304 306-PheGlyIleAspAlaValAspGlyValThrAspGly-317 331-CysPheGlyAspGluGlnGlnValAspAspPheGly-342 350-PheGlyGlyAsnGluGluGluValAlaLeu-359 369-ValAspValAsnGly-373 387-CysAsnArgArgAlaGlyGlyPhe-394 396-PheGlyAsnThrGln-400 411-GlnThrLeuArgAspLeuArgPhe-418 430-ArgAlaPheAspAlaGlyThrGlnArgAsnGly-440 443-ValMetProArgAsnProGlnAspPheLeuAsp-453 468-GluGlyGlnGlnGlnThrArg-474 Hydrophilic Regions - Hopp-Woods l-MetArgHisProPro-5 17-LeuLeuHisArgProLysSerValCysArgArgArgLysCysArgLeuLysAla-34 75-LeuTyrGluAspLysGluSerGlyAspAspPheAlaAspLysAspPheLeu-91 104-GluAlaAlaAspValPheArg-llO 117-AspGlyGlyLysAla-121 147-GlyAlaAspLysLeu-151 164-PheLysAsnArgGluGlyAlaAspValAspSerAspIle-176 184-LysThrLeuArgThr-188 205-GluGlyPheAspAspValArgLeu-212 217-GlyAspGlyGlyAsnArgArgAsnGlyMet-226 249-AspGluPheAspVal-253 271-ArgHisAlaAspGlnLeuGlnAlaAlaAlaAspLysAspValLeuGluArgAlaGlnThr-290 310-AlaValAspGlyValThrAspGly-317 331-CysPheGlyAspGluGlnGlnValAspAspPheGly-342 352-GlyAsnGluGluGluValAlaLeu-359 387-CysAsnArgArgAlaGly-392 412-ThrLeuArgAspLeuArgPhe-418 435-GlyThrGlnArgAsnGly-440 446-ArgAsnProGlnAsp-450 468-GluGlyGlnGlnGln-472 644-2 AMPHI Regions - AMPHI 13-MetAspThrAlaAlaPheLeuLysHisIleGluSerAlaPheArgArgIlePheSerAspGlyIleAspLeuM etArgTyrLeu-40 69-GlnPheGluIleGlnGluValLeuArgIleAlaGly-80 99-GlnProLeuGlnGluPheGlyAsp-106 139-ArgGluMetGlnSerTyrTyrGluTyrIleAspGly-150 160-TyrTrpGlnGlyAsn-164 182-LeuAlaLysValIleAspLeuLeu-189 234-AlaGlyLeuArgAlaPheGlnAsn-241 253-MetThrHisGlyIleMetGluTyrIleLeuGluAεnLeuGluArgTyrValArgAsn-271 291-GluIleLeuTyrArgTyrValCysHis-299 301-ValSerProValAlaProValAlaHis-309 314-AlaAsnIleValLysThrLeuAla-321 330-GlnMetLeuGlnLys-334 357-PheThrIlePheGluGlyProAsn-364 366-MetLeuTyrAlaGluIleTyrAspGlnPheValArgAla-378 397-AspArgLeuGlnThr-401 414-LeuProGluAspIleArgSerPhe-421 439-GlyLysIleIleAlaArgLeu-445 Antigenic Index - Jameson-Wolf 3-HisThrGluProSerAlaGlnProSerThrMetAsp-14 22-IleGluSerAlaPhe-26 29-IlePheSerAspGlyIleAsp-35 40-LeuProGluAspLysTrpLeu-46 57-PheLeuAspLysLysTyrGlyGlyArgLysGlySerGlnPheGluIle-72 103-GluPheGlyAspGluAlaGlnVal-110 118-PheLysGlyGluGlyGlyGlyLeuGly-126 128-ThrGluProGluThrSerGly-134 136-AlaIleAlaArgGluMetGlnSer-143 145-TyrGluTyrIleAspGlyGlnThr-152 160-TyrTrpGlnGlyAsnSerGlnSerAspPhe-169 174-AlaLysGluArgLysAsnGlyLysLeuAlaLys-184 193-LysThrTyrIleArg-197 199-GluThrLeuAlaSerGluGlyLeuArg-207 212-AlaValAsnArgIleAspAlaGluMet-220 228-LeuSerGlnSerAspAlaAlaGly-235 264-AsnLeuGluArgTyrValArgAsnAspIleLysPheValAspTyrGluArgArgGluIleArgArgArgHis GlnVal-289 339-LyεGlyPheGluArgGlyHisThrAlaGlyAsn-349 361-GluGlyProAεnAspMetLeu-367 378-AlaThrAlaGluGluLysGluAlaGlyMetLysLeuAspLysAsnGlnThrLeuLeuAspArgLeuGlnThr AspAlaArgPhe-405 407-AlaValAlaArgAspTyrThrLeuProGluAspIleArgSerPheLeu-422 451-AlaLysHisGluAspThrAla-457 463-AspIleArgLysAspIleLeuAspCysArgTyrCysGly-475 Hydrophilic Regions - Hopp-Woods 22-IleGluSerAlaPhe-26 29-IlePheSerAspGlyIleAsp-35 40-LeuProGluAspLysTrpLeu-46 58-LeuAspLysLysTyrGlyGlyArgLysGlySerGln-69 103-GluPheGlyAspGluAlaGlnVal-llO 118-PheLysGlyGluGlyGly-123 128-ThrGluProGluThrSerGly-134 136-AlaIleAlaArgGluMetGlnSer-143 174- laLysGluArgLysAsnGlyLysLeuAl Lys-184 212-AlaValAsnArgIleAspAlaGluMet-220 229-SerGlnSerAspAlaAlaGly-235 264-AsnLeuGluArgTyrValArgAsnAspIleLysPheValAspTyrGluArgArgGluIleArgArgArgHis GlnVal-289 339-LysGlyPheGluArgGlyHisThr-346 378-AlaThrAlaGluGluLysGluAlaGlyMetLysLeuAspLysAsnGlnThrLeuLeuAspArgLeuGlnThr AspAlaArgPhe-405 416-GluAspIleArgSerPheLeu-422 451-AlaLysHisGluAspThrAla-457 463-AsplleArgLysAspIleLeuAsp-470 645-2 AMPHI Regions - AMPHI 21-AsnThrLeuAsnArgCysCysLys-28 87-ArgThrLeuProSerLeuLysGlyLeuThrLys-97 Antigenic Index - Jameson-Wolf 17-ValGluGlnSerAsnThrLeuAsnArgCysCysLysLysSerArgMetThrCysSerSerSerArgSerArgS erCysProCys-44 47-ProMetArgAlaSerGlySerArgValSerSerArgSerArgIle-61 68-SerLeuCysArgLysAsnThrCysProProArgLeuSerSerArgAsnThrAlaSerArgThrLeuProSerL eu-92 99 -LeuThrAlaArgArgArgLeuGly- 106 HO-IleSerGluLysSerArgSerProSerAsn-119 137-ThrLeuAlaArgArgArgLeuSerCysSer-146 Hydrophilic Regions - Hopp-Woods 19-GlnSerAsnThrLeu-23 25-ArgCysCysLysLysSerArgMetThrCysSerSerSerArgSerArgSerCysPro-43 48-MetArgAlaSerGlySerArgValSerSerArgSerArgIle-61 69-LeuCysArgLysAsnThrCys-75 77-ProArgLeuSerSerArgAsnThrAlaSerArgThr-88 99-LeuThrAlaArgArgArgLeuGly-106 HO-IleSerGluLysSerArgSerProSer-118 137-ThrLeuAlaArgArgArgLeuSer-144 647 AMPHI Regions - AMPHI 38-GlyLysValCysArgCysPheGluGlnVal-47 69-ThrValPheArgGlnIleIleSerIleVal-78 Antigenic Index - Jameson-Wolf 26-GlyLeuValLysGluArgAlaArg-33 39-LysValCysArgCysPhe-44 54-GlyThrValGlyGlnThrGluArgGlyThr-63 81-AlaAspAlaGluArgThrAlaAlaHisSerArgGlyThrArgGly-95 Hydrophilic Regions - Hopp-Woods 26-GlyLeuValLysGluArgAlaArg-33 56-ValGlyGlnThrGluArgGlyThr-63 81-AlaAspAlaGluArgThrAlaAlaHisSerArgGlyThrArgGly-95 648 AMPHI Regions - AMPHI 7-ArgIleGluArgAlaValArg-13 15-AlaValIleAspValLeuAsnValAsp-23 44-AlaLeuAlaAspIleArgValLeu-51 94-AlaValAspLeuHisAlaValIleLysLeuThrAspThr-106 127-GlnGlyValGluGlnGly-132 147-ArgArgLeuLysHisPheLysGluGlyAsnAlaAlaGlyMetProArgPhe-163 182-AlaArgThrLeuGlyAsnValPheHis-190 194-GlySerGlyIleAspGlyIleGlnThrIleValAlaPheAsnGlnHisThr-210 Antigenic Index - Jameson-Wolf l-MetAsnArgArgAspAlaArgIleGluArgAlaValArg-13 23-AspAlaProGlySerGlyThrLeuLeuHisGlnArgGlyLysGlnValGlySerArgAsnAspAlaLeuAla- 46 65-GlyLysLysArgPheValGlnSerArgAsnLeuValGlyArgLyεGlnArgAsn-82 125-MetProGlnGlyValGluGlnGlyCysArgAla-135 143-ThrGlyPheAspArgArgLeuLysHisPheLysGluGlyAsnAla-157 172-ThrAlaAspThrSerGlyIleAspAlaAspAlaArgThr-184 191-AsnArgAlaGlySerGlyIleAspGly-199 Hydrophilic Regions - Hopp-Woods l-MetAsnArgArgAspAlaArgIleGluArgAlaValArg-13 33-GlnArgGlyLysGlnValGlySerArgAsnAspAlaLeuAla-46 65-GlyLysLysArgPheValGln-71 74-AsnLeuValGlyArgLysGlnArgAsn-82 127-GlnGlyValGluGlnGlyCysArgAla-135 143-ThrGlyPheAspArgArgLeuLysHisPheLysGluGlyAsnAla-157 173-AlaAspThrSerGlyIleAspAlaAspAlaArgThr-184 649-2 AMPHI Regions - AMPHI 8-AlaIleLeuLeuSerAlaIleLeuGlyLeuVal-18 32-ArgAspThrLysHis11eArgLysAlaAsn-41 62-SerGlnGlyAsnVal-66 68-GluLeuArgGluAsnLys-73 76-ArgLysAlaPheArgSerLeuPro-83 Antigenic Index - Jameson-Wolf l-MetSerValLysLys-5 25-GlyThrSerGluProAlaHisArgAspThrLysHisIleArgLysAlaAsnLys-42 45-LeuHisProGluCysArgLysTyrLeuGluArgArgAlaAla-58 61-ArgSerGlnGlyAsnValGlnGluLeuArgGluAsnLysLysAlaArgLysAlaPheArg-80 85-AlaGluGlnLysIleGlnCys-91 97-AlaPheAspAspPheAspGlyGlySerPheArgArg-108 Hydrophilic Regions - Hopp-Woodε l-MetSerValLysLys-5 25-GlyThrSerGluProAlaHisArgAspThrLysHisIleArgLysAlaAsnLys-42 47-ProGluCysArgLysTyrLeuGluArgArgAlaAla-58 64-GlyAsnValGlnGluLeuArgGluAsnLysLysAlaArgLysAlaPheArg-80 85-AlaGluGlnLysIleGlnCys-91 97-AlaPheAspAspPheAspGlyGlySerPheArgArg-108 650-2 AMPHI Regions - AMPHI 15-SerValCysProGly-19 5 -LeuTrpGlyGluLeuArgGln-63 72-ProGluLeuValArgArgHisGlu-79 89-PheAsnArgValIleAsn-94 137-SerGlyLeuTrpGln-141 173-AsnTyrLeuGlnTyrLeuTyrGlyLeuPheGlyAspTrpPro-186 198-AsnValGlyArgAlaIleAsnArgAlaArg-207 218-LeuArgMetProAsnGluThr-224 269-GluAlaIleAlaArgLeuAlaGlyIleThrGlnSer-280 314-SerAsnTyrLeuAsnAlaAlaProAsp-322 341-IleSerThrAlaThrGlyMet-347 349-IleAlaAspIleLysArgLeuAsnAsnLeu-358 376-LysThrLeuGlnThrAlaSerGlu-383 484-AlaAspGluLeuMetGln-489 496-LeuArgArgGlnAlaGlu-501 503-ThrIleSerAlaValIleGlyThrProAspThrValAlaGlu-516 556-AlaSerIleHisArgValVal-562 621-AspThrPheLysSerIle-626 636-AspIleArgArgLeu-640 Antigenic Index - Jameson-Wolf 1-MetSerLysLeuLys-5 24-GlnAsnThrSerSerHis-29 38-LeuAsnSerSerIleLeuAspLeuProProThrLysGlnTyrPhe-52 59-GlyGluLeuArgGlnGlyPheArgMetGlyGluValAsnProGluLeuValArgArgHisGluSerLysPhe- 82 92-ValIleAsnArgSerArgProTyr-99 105-AsnGluValLysLysArgAsnMetProAla-114 128-ThrLysAlaLysSerHisValGlyAlaSerGly-138 145-AlaThrGlyArgHisTyrGlyLeuGluLysThrProValTyrAspGlyArgHisAspVal-164 192-TyrAsnTrpGlyGluGlyAsnValGlyArgAlaIleAsnArgAlaArgAlaGlnGlyLeuGluProThrTyr GluAsnLeuArgMetProAsnGluThrArgAsnTyrVal-228 247-AsnIleSerAspIleAspAsnLysProTyr-256 259-AlaValGluProAspArgProLeuAspAsnGluAlaIleAla-272 296-ProLysSerLysArgLysLeu-302 318-AsnAlaAlaProAspSer-323 332-ProAlaAlaLysThrSerLeuSerAspIleSerThr-343 350-AlaAspIleLysArgLeuAsnAsnLeuAsnGly-360 370-LeuValAlaLysAsnGlyLysThrLeuGlnThrAlaSer-382 388-IleAspIleAspAsnThrProAspThrTyrArgSerAsnMetProAla-403 411-AlaArgIleArgPro-415 428-LeuProGlnLysThrValArgThrGluProAspProLeuValArgIleAlaGlu-445 454-GlnProGlnThrGluLysGlnThrAlaMetProSerGluThrGln-468 477-ProGlnAsnAspMetGlnAlaAlaAspGluLeu-487 491-ValAlaArgAsnAsnLeuArgArgGlnAlaGluGluThrIle-504 509-GlyThrProAspThrValAlaGluHisLysIleSerAlaSerProGln-524 527-AlaAlaAlaAspGlyLysArgArgValArgLeuGluThrArgValAlaLysAlaAlaAspGlyGluAlaGlu Ile-551 560-ArgValValGluGlyAspThr-566 583-ValAlaAsnAsnIleLysGlyAsnThrIleGlnLysGlyGlnValLeuArg-599 606-AlaGlnThrArgIleGluLysValSerTyrThrAlaArgLysGlyAspThrPheLys-624 634-11eAspAspIleArgArgLeuAsnProAsnLeu-644 647-IleAsnProGlyGlnArgValLysLeu-655 Hydrophilic Regions - Hopp-Woods l-MetSerLysLeuLys-5 61-LeuArgGlnGlyPheArgMetGlyGluValAsnProGluLeuValArgArgHisGluSerLysPhe-82 92-ValIleAsnArgSerArgPro-98 105-AsnGluValLysLysArgAsnMetProAla-114 128-ThrLysAlaLysSerHisVal-134 150-TyrGlyLeuGluLys-154 156-ProValTyrAspGlyArgHisAspVal-164 202-AlaIleAsnArgAlaArgAlaGlnGlyLeu-211 213-ProThrTyrGluAsnLeuArgMetProAsnGluThrArgAsnTyrVal-228 249-SerAspIleAspAsn-253 260-ValGluProAspArgProLeuAspAsnGluAlaIleAla-272 296-ProLysSerLysArgLysLeu-302 334-AlaLysThrSerLeu-338 350-AlaAspI1eLysArgLeuAsn-356 373-LysAsnGlyLysThrLeuGlnThrAlaΞer-382 389-AspIleAspAsnThrProAspThrTyrArg-398 411-AlaArgIleArgPro-415 431-LysThrValArgThrGluProAspProLeuValArgIleAlaGlu-445 455-ProGlnThrGluLysGlnThrAlaMetProSerGluThrGln-468 479-AsnAspMetGlnAlaAlaAspGluLeu-487 494-AsnAsnLeuArgArgGlnAlaGluGluThrIle-504 512-AspThrValAlaGluHisLysIleSerAla-521 527-AlaAlaAlaAspGlyLysArgArgValArgLeuGluThrArgValAlaLysAlaAlaAspGlyGluAlaGlu Ile-551 560-ArgValValGluGly-564 608-ThrArgIleGluLysValSerTyrThrAlaArgLysGlyAspThrPheLys-624 634-IleAspAspIleArgArgLeuAsn-641 649-ProGlyGlnArgValLysLeu-655 652-1 AMPHI Regions - AMPHI 6-AspIlePheAlaArg-10 52-ArgAspGlyAspLys-56 62-LysGlyValLeuLysAlaValGluHisValAsnAsnGlnIleAlaGlnAla-78 130-LeuTyrArgTyrLeuGlyGlyAlaGlyPro-139 149-ValIleAsnGlyGly-153 173-LysSerPheArgGluAlaLeuArgCys-181 184-GluIlePheHisAlaLeuLysLys-191 266-AlaGluPheAlaGluTyrLeuGluGlyLeuValAsn-277 323-AlaGluGlyIleGluLysGlyVal-330 338-ValAsnGlnIleGlyThrLeuSerGluThrLeuLysAlaValAspLeuAlaLys-355 377-AspLeuAlaValAla-381 391-SerLeuSerArgSerAspArgMetAlaLysTyrAsnGlnLeuLeuArgIleGluGlu-409 411-LeuAlaGluAlaAlaAspTyr-417 Antigenic Index - Jameson-Wolf ll-GluIleLeuAspSerArgGlyAsnProThrValGlu-22 36-AlaValProSerGlyAlaSerThrGlyGlnLysGluAlaLeuGluLeuArgAspGlyAspLysSerArgTyrS erGlyLysGlyValLeuLysAlaValGluHisValAsn-72 83-AspAlaAsnGluGlnSerTyr-89 97-LeuAspGlyThrGluAsnLysGlyAsnLeuGly-107 121-AlaAlaAlaGluAspSerGlyLeuPro-129 135-GlyGlyAlaGlyProMet-140 151-AsnGlyGlyGluHisAlaAsnAsnSer-159 173-LysSerPheArgGluAlaLeuArgCysGlyAla-183 190-LysLysLeuCysAspSerLysGlyPheProThrThrValGlyAspGluGlyGlyPhe-208 211-AsnLeuAsnSerHisLyεGluAlaLeu-219 243-CysAlaSerSerGluPheTyrLysAspGlyLysTyrHisLeuGluAlaGluGlyArgSerTyrThrAsn-26 5 283-SerIleGluAspGlyMetAspGluAsnAspTrpGluGly-295 299-LeuThrGluLysLeuGlyGlyArgValGlnLeuValGlyAspAspLeu-314 318-AsnProLysIleLeuAlaGluGlyIleGluLysGlyVal-330 352-AspLeuAlaLysArgAsnArgTyrAla-360 363-MetSerHisArgSerGlyGluThrGluAspSerThrIle-375 388-LysThrGlySerLeuSerArgSerAspArgMetAlaLys-400 405-LeuArgIleGluGluGluLeuAlaGluAlaAlaAspTyrProSerLys-420 Hydrophilic Regions - Hopp-Woods ll-GluIleLeuAspSerArgGlyAsnProThrValGlu-22 43-ThrGlyGlnLysGluAlaLeuGluLeuArgAspGlyAspLysSerArgTyrSerGly-61 63-GlyValLeuLysAlaValGlu-69 97-LeuAspGlyThrGluAsnLysGlyAsnLeu-106 121-AlaAlaAlaGluAspSerGly-127 153-GlyGluHisAlaAsn-157 173-LysSerPheArgGluAlaLeuArgCysGlyAla-183 190-LysLysLeuCysAspSerLysGly-197 202-ValGlyAspGluGlyGlyPhe-208 213-AsnSerHisLysGluAlaLeu-219 247-GluPheTyrLysAspGlyLysTyrHisLeuGluAlaGluGlyArgSerTyrThr-264 283-SerIleGluAspGlyMetAspGluAsnAspTrpGluGly-295 299-LeuThrGluLysLeuGlyGly-305 321-IleLeuAlaGluGlyIleGluLysGlyVal-330 352-AspLeuAlaLysArgAsnArgTyr-359 364-SerHisArgSerGlyGluThrGluAspSerThrIle-375 391-SerLeuSerArgSerAspArgMetAlaLys-400 405-LeuArgIleGluGluGluLeuAlaGluAlaAlaAspTyrProSer-419 653 AMPHI Regions - AMPHI 6-MetArgMetProGluValThrLysGlyPheSerGlySer-18 60-ThrMetArgLysProArgLeuThr-67 75-AlaLeuIlePheThrCysPheAla-82 96-ThrAlaLeuAlaAlaIleThrCysIle-104 lll-LeuGlyLysMetGluGluPheAsn-118 Antigenic Index - Jameson-Wolf 4-GluProMetArgMetProGluValThrLysGlyPheSerGlySer-18 45-GlyCysArgSerThrArgLysThr-52 56-ValArgProGluThrMetArgLysProArgLeuThrAsnSerSerAla-71 86-AsnSerGlyCysAsnAla-91 103-CysIleSerGlyProProCysArgLeuGlyLysMetGluGlu-116 125-SerArgHisLysIleThrProProArgGlyProArgArgVal-138 145-ThrLysSerGlnAsnGlyThrGly-152 154-GlyTyrSerProProAlaThrArgProAla-163 Hydrophilic Regions - Hopp-Woods 4-GluProMetArgMetProGluValThrLys-13 47-ArgSerThrArgLysThr-52 57-ArgProGluThrMetArgLysProArgLeuThrAsn-68 107-ProProCysArgLeuGlyLysMetGluGlu-116 126-ArgHisLysIleThrProProArgGlyProArg-136 158-ProAlaThrArgProAla-163 656 AMPHI Regions - AMPHI 14-MetAlaArgThrLeuGlyAlaProGlu-22 42-ArgArgProSerThr-46 92-LeuAlaSerLeuAsnLysSerCys-99 117-MetGlyArgThrIleThr-122 Antigenic Index - Jameson-Wolf 6-GlySerThrSerSer-10 19-GlyAlaProGluSerValProAlaGlyLysValAlaAla-31 40-SerPheArgArgProSerThrLeuGlu-48 74-ArgProThrSerLeuArgProLysSerIleAsn-84 94-SerLeuAsnLysSerCysSerLeuAlaArgSerSerAlaGlyValLeuProArgArgArgValProAla-116 122-ThrSerLeuArgSerArgArgThrArgIleSerGlyGluGluProThrMetTrpLysSerProLysSer-14 4 Hydrophilic Regions - Hopp-Woods 40-ΞerPheArgArgProSerThr-46 76-ThrSerLeuArgProLysSerIle-83 99-CysSerLeuAlaArgSerSer-105 109-LeuProArgArgArgValProAla-116 124-LeuArgSerArgArgThrArgIleSerGlyGluGluProThrMet-138 140-LysSerProLysSer-144 657 AMPHI Regions - AMPHI 9-ProAlaMetLeuGly-13 2O-LeuGlyArgMetPheThr-25 62-AlaAlaLeuAspGluLeuAlaLysCysAlaAla-72 85-MetArgPheLeuAlaLys-90 132-AεpIleThrGluAlaSer-137 139-GlnPheLeuProGlyIleLeuLysThr-147 161-LysThrLeuAspGluLeuLysAlaAla-169 178-CysValLeuGluLysMetValAspLeu-186 203-GlnThrPheAspProAlaGluAsnIle-211 232-GlnGlnAlaArgGlnMetAlaGlnArgLeuAlaAspGluLeuAspTyrValGlyValLeu-251 314-AsnIleLeuGlyAsp-318 Antigenic Index - Jameson-Wolf 16-GlyGlyGlyGlnLeuGly-21 37-ValLeuAspProAspProAspAlaProAla-46 62-AlaAlaLeuAspGluLeuAlaLys-69 75-ThrGluPheGluAsnValAsnAlaAspAla-84 91-HisThrAsnValSerProSerGlyAsp-99 106-AsnArgIleGlnGluLysAlaTrpIle-114 128-CysLysAlaGluAspIleThrGluAla-136 150-LeuGlyTyrAspGlyLysGlyGlnIleArgValLysThrLeuAspGluLeuLysAlaAlaPhe-170 182-LysMetValAspLeuArgSerGluIle-190 197-LeuAsnAsnAspAsnValGlnThrPheAspProAlaGluAsnIleHisGluAsnGly-215 230-ValGlnGlnGlnAlaArgGlnMetAla-238 240-ArgLeuAlaAspGluLeuAsp-246 269-IleAlaProArgProHisAsnSerGlyHisHis-279 288-GlnPheGlnGlnGln-292 300-ProProAlaAspThrLysLeuLeuSer-308 319-ValTrpGlnGluAspGlyGlyGluProAspTrp-329 333-GlnSerHisProAsnAla-338 344-GlyLysLysThrAlaHisLysGlyArgLysMetGly-355 361-ThrThrAspSerAspThrAlaPheGlnGluAlaLysLysLeuHis-375 Hydrophilic Regions - Hopp-Woods 37-ValLeuAspProAspProAspAlaProAla-46 62-AlaAlaLeuAspGluLeuAlaLys-69 75-ThrGluPheGluAsnValAsn-81 128-CysLysAlaGluAspIleThrGluAla-136 152-TyrAspGlyLysGlyGlnIleArgValLysThrLeuAspGluLeuLysAlaAlaPhe-170 182-LysMetValAspLeuArgSerGluIle-190 197-LeuAsnAsnAspAsn-201 206-AspProAlaGluAsnIleHis-212 230-ValGlnGlnGlnAlaArgGlnMetAla-238 240-ArgLeuAlaAspGluLeuAsp-246 269-IleAlaProArgProHisAsn-275 301-ProAlaAspThrLysLeu-306 320-TrpGlnGluAspGlyGlyGluProAsp-328 344-GlyLysLyεThrAlaHisLysGlyArgLysMetGly-355 362-ThrAspSerAspThrAlaPheGlnGluAlaLysLysLeuHis-375 658 AMPHI Regions - AMPHI 28-ArgGlnTyrAlaAspIleIleGlnPheValArgGlnAlaLeuArgHisLeuProArgLeuLeuLeu-49 68-ValAspValPheGlyArgValGluSer-76 92-ThrAlaGlnIleHisHiεPhePheGlnAsnAlaIleHisAla-105 139-GlnLysLeuArgAlaCysPheSerAspValPheSer-150 Antigenic Index - Jameson-Wolf 6-ValArgAlaArgGlyAspPheValAspAspGlnPheMetArgValThrAspAsnLysHisPhe-26 40-AlaLeuArgHiεLeuPro-45 53-ThrGlnSerArgGlyAspAspGlyIleSerGlnAspAlaVal-66 72-GlyArgValGluSer-76 107-ValPheGlyLysArgGlyPheGlu-114 130-GlnArgSerArgPheGlnAspAlaGlyGlnLysLeuArgAlaCysPhe-145 155-LeuIleArgArgGlyLeuGlnSerArgPhe-164 177-AsnArgHisThrIleAlaAlaArgGlyAsnIle-187 193-LysAlaHisArgIleGly-198 202-PheLysPheSerGlyHisArgArgAla-210 219-LeuValValLysArgArgAlaGln-226 230-GlyLysPheCysCysArgArgValArgIleGlyValGluAsn-243 250-GlyPheGlyGlyAsnGlyLysHisSerAla-259 Hydrophilic Regions - Hopp-Woods 6-ValArgAlaArgGlyAspPheValAsp-14 16-GlnPheMetArgValThrAspAsnLysHisPhe-26 53-ThrGlnSerArgGlyAspAspGlyIleSer-62 72-GlyArgValGluSer-76 130-GlnArgSerArgPheGlnAspAlaGlyGlnLysLeuArgAlaCysPhe-145 155-LeuIleArgArgGlyLeuGln-161 193-LysAlaHisArgIleGly-198 205-SerGlyHiεArgArgAla-210 220-ValValLysArgArgAlaGln-226 233-CysCysArgArgValArgIleGlyVal-241 253-GlyAsnGlyLysHisSerAla-259 661-2 AMPHI Regions - AMPHI 19-GlylleThrAspLysProPheArgArgLeuCysArgAspPheGlyAlaGly-35 37-AlaValCysGluMetLeu-42 75-AspProGlnGlnMetAlaAspAlaAla-83 122-AlaAlaIleLeuGluAlaValValArg-130 152-ProValIleAlaLysIleAlaGlu-159 256-AlaAlaAlaIleLeuAsnHisIleArgAlaIleHisAlaPheTyrGly-271 297-ArgArgGluIleAsnArgLeuAspSer-305 310-TyrAspMetLeuAlaGlyTyrLeuGluArgLeuAlaGluLys-323 Antigenic Index - Jameson-Wolf 20-IleThrAspLysProPheArgArgLeuCysArgAspPheGlyAlaGly-35 42-LeuThrSerAspProThrLeuArgAsnThrArgLysThrLeuHisArgSerAεpPheAlaAspGluGlyGly- 65 72-AlaGlySerAspProGlnGlnMetAlaAspAlaAlaArg-84 97-AsnMetGlyCysProAlaLysLysValCys-106 143-GlyTrpHisAspAspHisGlnAsnLeu-151 157-IleAlaGluAspCysGly-162 169-HisGlyArgThrArgThrGlnMetTyrLysGlyGluAlaArgTyr-183 187-AlaGluThrLysCysArgLeu-193 200-AsnGlyAspIleThrSerProGlnLysAla-209 222-MetIleGlyArgGlyAlaGlnGlyArgProTrpPhe-233 236-AspLeuLysHisTyrAla-241 270-TyrGlyAspThrAlaGly-275 277-ArgIleAlaArgLysHis-282 288-AspGluMetProAspGlyGluGlnThrArgArgGluIleAsnArgLeuAspSerAla-306 319-ArgLeuAlaGluLysThrAspSerTrp-327 330-AlaTyrArgProAsnAla-335 Hydrophilic Regions - Hopp-Woods 20-IleThrAspLysProPheArgArgLeuCysArgAspPhe-32 46-ProThrLeuArgAsnThrArgLysThrLeuHisArgSerAspPheAlaAspGluGlyGly-65 73-GlySerAspProGlnGlnMetAlaAspAlaAlaArg-84 100-CysProAlaLysLysValCys-106 157-IleAlaGluAspCysGly-162 170-GlyArgThrArgThrGlnMetTyrLysGlyGluAlaArgTyr-183 187-AlaGluThrLysCysArgLeu-193 203-IleThrSerProGlnLysAla-209 236-AspLeuLysHisTyrAla-241 277-ArgIleAlaArgLys-281 289-GluMetProAspGlyGluGlnThrArgArgGluIleAsnArgLeuAspSerAla-306 319-ArgLeuAlaGluLysThrAspSer-326 663 AMPHI Regions - AMPHI 19-ProPheAlaLeuLeuHisLysIleAlaAspLeuThrGlyLeuLeuAlaTyr-35 47-IleAεnLeuAlaLysCysPheSerGluTrp-56 66-LysGlnHisPheLysHisMetAlaLysLeu-75 87-AlaGlyArgLeuLysSerLeuValArg-95 168-GluGlyLeuArgAlaLeuValLysGlnPheArgLys-179 209-ThrIleThrGlyLeuSerArgIleAlaAlaLeuAlaAsn-221 243-ProAlaTrpLysSer-247 258-GlnArgMetAsnArgPheIleGluAspArgValArgGluHis-271 Antigenic Index - Jameson-Wolf 38-ValLysProArgArgArgl1eGlyGlu-46 56-TrpSerGluGluLysArgLysThrValLeu-65 87-AlaGlyArgLeuLysSer-92 94-ValArgTyr rgAsnLysHisTyrLeuAsp-103 105-AlaLeuAlaAlaGlyGluLys-lll 139-TyrSerHisGlnLysAsnLysIleLeuAsp-148 150-GlnIleLeuLysGlyArgAsnArgTyr-158 166-ArgThrGluGlyLeuArgAlaLeu-173 175-LysGlnPheArgLysSerSerAla-182 188-ProAspGlnAspPheGlyArgAsnAspSerVal-198 229-ProValArgGluAlaAspAεnThr-236 243-ProAlaTrpLysSerPheProGlyGluAspAlaLysAlaAspAlaGlnArgMetAsnArgPheIleGluAsp ArgValArgGluHisProGlu-273 280-LysArgPheLysThrArgProGluGlySerProAspPheTyr-293 Hydrophilic Regions - Hopp-Woods 39-LysProArgArgArgIleGlyGlu-46 56-TrpSerGluGluLysArgLysThrValLeu-65 88-GlyArgLeuLysSer-92 94-ValArgTyrArgAsn-98 105-AlaLeuAlaAlaGlyGluLys-lll 142-GlnLysAsnLysIleLeuAsp-148 150-GlnlleLeuLysGlyArgAsnArgTyr-158 166-ArgThrGluGlyLeuArgAlaLeu-173 176-GlnPheArgLysSerSer-181 190-GlnAspPheGlyArgAsnAspSerVal-198 229-ProValArgGluAlaAspAsn-235 248-PheProGlyGluAspAlaLysAlaAspAlaGlnArgMetAsnArgPheIleGluAspArgValArgGluHis ProGlu-273 280-LysArgPheLysThrArgProGluGlySerPro-290 664-2 AMPHI Regions - AMPHI 47-AlaAspValPheAspAlaAlaHisGlyAlaAlaGly-58 90-ProValValGluIle-94 158-PheHisArgValPheGlnArgPhe-165 201-AlaArgAspGlnSerLysGlnIleAlaArgPheGlyLysArg-214 Antigenic Index - Jameson-Wolf 27-GlyAlaHisArgMetGlyGlyArgAlaCysVal-37 73-PheLeuGlnArgLysLeuGluPro-80 108-IleGlyGlyGlyAlaAlaValGlyLysAspGluLeuGlyValLysAspValGln-125 137-AlaHisGlyAspAspHisGluAsn-144 165-PheHisGlyLysAlaAspLeuGly-172 177-GlyGlyValLysLeuAspPhe-183 199-GlnIleAlaArgAspGlnSerLysGlnIleAlaArgPheGlyLysArgValPhe-216 Hydrophilic Regions - Hopp-Woodε 28-AlaHisArgMetGlyGly-33 74-LeuGlnArgLysLeuGluPro-80 113-AlaValGlyLysAspGluLeuGlyValLysAspValGln-125 137-AlaHisGlyAspAspHisGluAsn-144 165-PheHisGlyLysAlaAspLeuGly-172 177-GlyGlyValLysLeuAspPhe-183 199-GlnIleAlaArgAspGlnSerLysGlnIleAlaArgPheGlyLys-213 665-1 Hydrophilic Regions - Hopp-Woods 39-LysProArgArgArgIleGlyGlu-46 56-TrpSerGluGluLysArgLysThrValLeu-65 88-GlyArgLeuLysSer-92 94-ValArgTy rgAsn-98 105-AlaLeuAlaAlaGlyGluLys-lll 142-GlnLysAsnLysIleLeuAsp-148 150-GlnIleLeuLysGlyArgAsnArgTyr-158 166-ArgThrGluGlyLeuArgAlaLeu-173 176-GlnPheArgLysSerSer-181 190-GlnAspPheGlyArgAsnAspSerVal-198 229-ProValArgGluAlaAspAsn-235 248-PheProGlyGluAspAlaLysAlaAspAlaGlnArgMetAsnArgPheIleGluAspArgValArgGluHis ProGlu-273 280-LysArgPheLysThrArgProGluGlySerPro-290 Antigenic Index - Jameson-Wolf 8-LeuLysAspTyrGlnThrProAlaTyr-16 26-AspIleAsnGluPro-30 32-ThrValValLysSerArgLeuThrValGluProGlnArgValGlyGlu-47 49-LeuValLeuAspGlySerAla-55 80-GlyValProSerGluArgPheThrVal-88 90-ValGluThrGluIleLeuProAlaGluAsnLysSerLeu-102 115-GlnCysGluProGluGlyPheArgLys-123 128-IleAspArgProAspValMetSer-135 142-ValAlaAspLysLysArgTyrPro-149 153-SerAsnGlyAsnLysIleAspGlyGlyGluPheSerAspGlyArgHisTrpValLysTrpGluAspProPhe SerLysProSer-180 191-AlaValThrGluAspTyr-196 200-MetSerGlyArgAsnValLysIle-207 211-ThrThrGluAlaAspLysProLysVal-219 230-MetLysTrpAspGluThrArgPhe-237 255-AsnMetGlyAlaMetGluAsnLysGlyLeu-264 275-AspSerArgThrAlaThrAspThrAspPheGluGlyIleGlu-288 295-TyrPheHisAsnTrpThrGlyAsnArgValThrCysArgAspTrp-309 313-SerLeuLysGluGly-317 322-ArgAspGlnGluPheSerGlyAspArgAlaSerArgAlaValArgArgIleGluAsn-340 347-HisGlnPheProGluAspAlaGlyProThrAlaHisProValArgProAlaSerTyrGluGluMetAsn-36 9 376-ValTyrGluLysGlyAlaGluVal-383 394-GluGlyPheGlnLysGlyMet-400 404-PheGlnArgHisAεpGlyGlnAlaValThrCysAspAspPheArgAlaAlaMet-421 437-SerGlnAlaGlyThrPro-442 444-LeuGluAlaGluGlyArgLeuLysAsnAsnIle-454 459-ValLysGlnThrValProProThrProAspMetThrAspLysGlnPro-474 483-LeuLeuAsnArgAsnGlyGluAlaVal-491 494-AspTyrGlnGlyLysArgAlaThrGlu-502 537-LeuAsnTyrProTyrSerAspAspAspLeu-546 552-HisAspSerAspAla-556 578-LeuSerAspGlyValGluLeuProLysHisGluLysLeu-590 594-ValGluLysValIleSerAspAspLeuLeu-603 614-ValProSerGluAlaGluLeuTrpAspGlyAlaGluAsnIleAspProLeuArg-631 633-HisGlnAlaArgGluAlaLeu-639 652-HisGluLeuAsnArgGlnAlaAlaLysGlnGluAsnGlnSerTyrGluTyrSerProGluAlaAlaGly-67 4 677-ThrLeuArgAsnValCys-682 689-AlaAspProAlaHis-693 696-ThrValAlaGluLysTyrGlyGlu-703 719-AsnGlyAsnGluSerAspThrArgAsnArgLeu-729 733-PheAlaAspLysPheSerAspAspAlaLeuVal-743 752-GlySerSerArgArgSerAspThrLeuGlnGlnVal-763 768-GlnHisProLysPheSerLeuGluAsnProAsnLysAlaArgSer-782 785-GlySerPheSerArgAsnValPro-792 795-HisAlaGluAspGlySerGlyTyrArgPheIleAla-806 808-LysValIleGluIleAspArgPheAsnProGlnVal-819 831-AsnLysLeuGluProHisArgLysAsnLeuVal-841 844-AlaLeuGlnArgIleArgAlaGlnGluGlyLeuSerLysAspValGlyGluIleVal-862 Hydrophilic Regions - Hopp-Woods 32-ThrValValLysSerArgLeuThrValGluProGlnArgValGlyGlu-47 82-ProSerGluArgPheThrVal-88 90-ValGluThrGluIleLeuProAlaGluAsnLysSer-101 116-CysGluProGluGlyPheArg-122 129-AspArgProAspValMetSer-135 142-ValAlaAspLysLysArgTyr-148 154-AsnGlyAsnLysIleAspGlyGlyGluPheSerAsp-165 170-ValLysTrpGluAspProPheSer-177 201-SerGlyArgAsnValLys-206 213-GluAlaAspLysProLysVal-219 230-MetLysTrpAspGluThrArgPhe-237 258-AlaMetGluAsnLysGly-263 275-AspSerArgThrAlaThrAspThrAspPheGluGly11eGlu-288 313-SerLeuLysGluGly-317 322-ArgAspGlnGluPheSerGlyAspArgAlaSerArgAlaValArgArgIleGluAsn-340 348-GlnPheProGluAspAlaGlyPro-355 363-AlaSerTyrGluGluMetAsn-369 376-ValTyrGluLysGlyAlaGluVal-383 394-GluGlyPheGlnLysGlyMet-400 406-ArgHisAspGlyGln-410 413-ThrCysAspAspPheArgAlaAlaMe -421 444-LeuGluAlaGluGlyArgLeuLysAsnAsnIle-454 467-ProAspMetThrAspLysGlnPro-474 495-TyrGlnGlyLysArgAlaThrGlu-502 541-TyrSerAspAspAspLeu-546 552-HisAspSerAspAla-556 580-AspGlyValGluLeuProLysHisGluLysLeu-590 594-ValGluLysValIleSer-599 616-SerGluAlaGluLeu-620 622-AspGlyAlaGluAsnIleAspPro-629 633-HisGlnAlaArgGluAlaLeu-639 652-HisGluLeuAsnArgGlnAlaAlaLysGlnGluAsnGlnSer-665 689-AlaAspProAlaHiε-693 696-ThrValAlaGluLysTyrGlyGlu-703 719-AsnGlyAsnGluSerAspThrArgAsnArgLeu-729 733-PheAlaAspLysPheSerAsp-739 753-SerSerArgArgSerAεpThr-759 776-AsnProAsnLysAlaArgSer-782 795-HisAlaGluAspGlySerGly-801 808-LysValIleGluIleAspArgPheAsn-816 831-AsnLysLeuGluProHisArgLysAsnLeuVal-841 844-AlaLeuGlnArgIleArgAlaGlnGluGlyLeuSerLysAspValGlyGluIleVal-862 666-2 AMPHI Regions - AMPHI 89-GlyTyrAspIleLeuLysGlnGlyGlySer-98 162-LeuLysPheMetGluAla-167 177-ProAlaIleProLysLeuMetGluThrIleHisGln-188 193-LeuProTrpGlyLysLeuPheAspThrProIleArg-204 227-LeuAlaArgTyrProLys-232 249-LeuLeuLysAsnLeuGluPheAlaAspSerValGlnAlaLeu-262 265-GlnGlyAlaLysAlaLeuHisThr-272 274-LysTyrAlaGlnAsnIleValSerValVal-283 295-LeuGlnAspLeuSerAspTyrGln-302 313-TyrArgIleTyrGluValCysGlyMetGly-322 332-GlyGlnIleLeuGlyIleLeuAsnGluPheSer-342 353-LeuArgLeuLeuGlyAsp-358 411-AspPheIleHisGluTrp-416 424-LeuProSerThrSerHis-429 433-ValAspLysAlaGlyAsn-438 441-SerMetThrThrSerIleGluAsnAlaPheGlySer-452 511-ProGlyGlySerArgIleIleGlyTyrValAlaLys-522 537-AlaIleSerAlaProAsnLeuLeuAsnArgPheGly-548 562-GlnGlnAlaLeuAεnAsp-567 590-ArgLeuValGlyGly-594 Antigenic Index - Jameson-Wolf 5-AsnHisGlnSerAsnSerGlyGluGlyValLeu-15 40-AsnGlnGlyLysValAsnThr-46 54-AlaAspAlaHisThrProGluHisAlaThr-63 65-LeuThrGluGlnLysGln-70 92-IleLeuLysGlnGlyGlySerAlaAla-100 114-GluProGlnSerSerGlyLeuGlyGly-122 130-AspAsnThrAlaLysThr-135 137-ThrThrPheAspGlyArgGluThrAlaPro-146 154-PheLeuAspLysAspGlyGlnPro-161 169-ValGlyGlyArgSerValGly-175 197-LysLeuPheAspThrProIleArgLeuAlaLysGlnGlyPhe-210 212-ValSerProArgLeu-216 221-GluGlnAsnGlnGlnHis-226 228-AlaArgTyrProLysThrAlaAla-235 271-HisThrGlyLysTyr-275 284-GlnAsnAlaLysAspAsnProGlyGln-292 296-GlnAspLeuSerAspTyrGlnValValGluArgProProValCyε-310 320-GlyMetGlyAlaProSerSerGlyGly-328 340-GluPheSerProAsnGlnValGlyTyrAspAlaGluGlyLeuArgLeuLeuGlyAspAlaSerArg-361 363-AlaPheAlaAspArgAspValTyrLeuGlyAspProAspPheVal-377 384-LeuIleSerLysAspTyrLeuLysHisArgSerGlnLeuLeuGluGlnSerAspLysAlaLeu-404 431-SerIleValAspLysAlaGly-437 445-SerIleGluAsnAlaPhe-450 472-ProIleLysGlnGlyLysGlnValAlaAsnArgValGluProGlyLysArgProArgSerSerMet-493 500-LysAlaGlyLysProTyrMet-506 510-SerProGlyGlySerArgIle-516 548-GlySerTyrGluLeuGluThrGlyThr-556 566-AsnAspLeuGlyTyrLysThrAspValArgGluLeuAsnSerGlyVal-581 587-GluProSerArgLeuValGlyGlyAlaAspProArgArgGluGlyArgValMetGlyAsp-606 Hydrophilic Regions - Hopp-Woods 8-SerAsnSerGlyGlu-12 40-AsnGlnGlyLysValAsnThr-46 55-AspAlaHisThrProGluHis-61 65-LeuThrGluGlnLysGln-70 96-GlyGlySerAlaAla-100 139-PheAspGlyArgGluThrAlaPro-146 154-PheLeuAspLysAspGlyGlnPro-161 203-IleArgLeuAlaLysGlnGlyPhe-210 284-GlnAsnAlaLysAspAsnProGly-291 302-GlnValValGluArgProPro-308 348-TyrAspAlaGluGlyLeuArgLeuLeuGlyAspAlaSerArg-361 363-AlaPheAlaAspArgAspValTyrLeuGly-372 388-AspTyrLeuLysHisArgSerGlnLeuLeuGluGlnSerAspLysAlaLeu-404 432-IleValAspLysAlaGly-437 472-ProIleLysGlnGlyLysGlnValAlaAsnArgValGluProGlyLysArgProArgSerSerMet-493 572-ThrAspValArgGluLeuAsnSer-579 595-AlaAspProArgArgGluGlyArgValMetGlyAsp-606 667-2 AMPHI Regions - AMPHI 6-GlyLeuCysGlyGlnValIlePro-13 48-IleIleAlaAspPheLeuGlnProAlaArg-57 59-GluCysLeuProAsnLeuAlaAla-66 74-LysThrAlaGlnPhe-78 115-IleAlaAlaValAlaGluIle-121 153-ThrAspGlnLeuArgArgMetPhePheAsnGlnPheGluLysPheSerAsnAspHis-171 202-LysMetMetLeuHisLys-207 234-ValGlnCysSerAspThr-239 Antigenic Index - Jameson-Wolf 27-ProAlaAlaAspGlnThrGluThrGln-35 56-AlaArgMetGluCysLeuPro-62 71-LeuAlaArgLysThrAlaGln-77 89-ArgLeuValLysArgGluGlnIle-96 152-ProThrAspGlnLeuArg-157 165-GluLysPheSerAsn-169 190-ProThrHisAlaAlaArgAsnArgHisAsnLeu-200 226-ValGlyGlnArgGlyArgGlnLeu-233 248-IleGluSerGlnAsnArgGlyHisAspSer-257 Hydrophilic Regions - Hopp-Woods 27-ProAlaAlaAspGlnThrGluThrGln-35 56-AlaArgMetGluCys-60 71-LeuAlaArgLysThrAlaGln-77 89-ArgLeuValLysArgGluGlnIle-96 165-GluLysPheSerAsn-169 192-HisAlaAlaArgOAsnArgHisAsnLeu-200 228-GlnArgGlyArgGln-232 250-SerGlnAsnArgGlyHisAsp-256 669-2 AMPHI Regions - AMPHI 24-PheLeuGlyIleLysArgPhePheArgGlnPro-34 60-LysLeuHisArgAlaPhe-65 95-GlnIlePheArgHisValGlnSer-102 119-ThrArgGlnAlaPhe-123 Antigenic Index - Jameson-Wolf 5-ArgLeuGlnAsnGlyArgThrGlyArgAsnProProPheValGlnLysArgLeuAsp-23 29-ArgPhePheArgGlnProLeuGluMetArgArglleileLysLysHisGlnProIleAsnAla-49 69-GlyArgLysArgProHisHisHisAspSerSerLeuArgArgGlnHisGlyIleGluGlyMetGlyPhe-91 99-HisValGlnSerSerAsnArgGlnAsnGlyArgGlnProVal-112 114-AlaProAsnArgGlnThrArgGlnAlaPhe-123 137-ProThrSerAsnGlyTyrCys-143 149-SerThrHisArgThrThrHisLysAlaProProTyr-160 Hydrophilic Regions - Hopp-Woods 7-GlnAsnGlyArgThrGlyArgAsn-14 18-ValGlnLysArgLeuAsp-23 34-ProLeuGluMetArgArgIleIleLysLysHisGlnPro-46 69-GlyArgLysArgProHisHisHisAspSerSerLeuArgArgGlnHisGly-85 lOl-GlnSerSerAsnArgGlnAsnGlyArg-109 116-AsnArgGlnThrArgGlnAlaPhe-123 151-HisArgThrThrHisLys-156 670-2 AMPHI Regions - AMPHI 10-ArgSerCysPheGly-14 16-ValLysAsnAlaSerGlyValSer-23 3 -IleThrArgSerAla-38 77-ValGlySerSerAsnAsnIle-83 Antigenic Index - Jameson-Wolf 4-CysArgAsnCysLeuAlaArgSerCys-12 18-AsnAlaSerGlyValSerSerSerArgIleCysProLeuSer-31 33-LysIleThrArgSerAlaThrSerArgAlaAsnProIle-45 65-AsnThrSerProThrIleSerGlySerSerAlaGluValGlySerSerAsnAsnIleThrArgGlySerIleA laLysProArgAlaIleAla-95 98-CysCysTrpProProGluSerTrpGluGlyLysAla-109 114-AlaSerProThrArgSerLysSerSer-122 128-AlaCysSerAlaPhe-132 Hydrophilic Regions - Hopp-Woods 33-LysIleThrArgSerAlaThrSerArgAlaAsn-43 73-SerSerAlaGluValGlySer-79 87-SerIleAlaLysProArgAlaIleAla-95 116-ProThrArgSerLysSer-121 671 AMPHI Regions - AMPHI 11-PheAsnAlaProAsn-15 72-LysGluAlaAlaLysSerLeu-78 96-ThrProArgIleAla-100 119-ArgLeuPheIleArgTyr-124 Antigenic Index - Jameεon-Wolf 9-ThrProPheAεnAlaProAsnThrProProLysMetArgLeuAlaLysProLysProThrAlaGlu-30 45-GlnAlaMetThrAsnArgGluMetAsnAspArgAlaAsnAlaAsnArgArgGlyTrpAsnGluAlaLysAlaA rgSerAlaLysGluAlaAlaLysSerLeuAlaLysLysLysGluThrThr-85 98-ArgIleAlaAspSerThrMet-104 110-AlaGluThrArgArgSerAlaMet-117 125-LeuThrGlyAεpThr-129 Hydrophilic Regions - Hopp-Woods 16-ThrProProLysMetArgLeuAlaLysProLysProThrAla-29 47-MetThrAsnArgGluMetAsnAspArgAlaAsnAlaAsnArgArgGlyTrpAsnGluAlaLysAlaArgSerA laLysGluAlaAlaLysSerLeuAlaLysLysLysGluThrThr-85 110-AlaGluThrArgArgSerAlaMet-117 672 AMPHI Regions - AMPHI 38-ArgAlaValAspIleAlaArgAlaLysLys-47 50-AlaAlaLeuProProPheValSerValVal-59 67-AlaGlnAsnIleArgArgIleLeuAlaGluValPro-78 91-AlaPheCysArgGlnPheHisArgProTyr-100 105-ArgValGlnThrAlaSerAspIle-112 115-AlaAlaThrArgPheProAsp-121 131-HisProSerGluTyrGlyGlyThr-138 163-ProGluAsnValGlyGluAlaValArgIleThrGlyAlaGluSer-177 Antigenic Index - Jameson-Wolf l-MetArgLysIleArgThrLysIle-8 13-ThrProGluAspAlaAlaAla-19 35-GlySerSerArgAlaValAspIleAlaArgAlaLysLysIleThr-49 65-GluSerAlaGlnAsnIleArgArgIleLeuAla-75 84-PheHisGlyAspGluAspAspAlaPhe-92 llO-SerAspIleArgAsnAlaAlaThrArgPheProAspAla-122 130-TyrHisProSerGluTyrGlyGlyThrGlyAsnArgPheAsp-143 148-AlaGluTyrSerGlyLysPro-154 160-GlyLeuThrProGluAsnValGlyGluAlaValArg-171 176-GluSerValAspValSerGlyGlyValGluAlaSerLysGlyLysLysAspAlaAlaLys-195 202 -ThrAlaAsnArgLeuSerArg-208 Hydrophilic Regions - Hopp-Woods l-MetArgLysIleArgThrLysIle-8 13-ThrProGluAspAlaAlaAla-19 36-SerSerArgAlaValAspIleAlaArgAlaLysLysIleThr-49 66-SerAlaGlnAsnIleArgArgIleLeuAla-75 85-HisGlyAspGluAspAspAlaPhe-92 110-SerAspIleArgAsnAlaAla-116 134-GluTyrGlyGlyThrGlyAsn-140 165-AsnValGlyGluAlaValArg-171 176-GluSerValAspVal-180 184-ValGluAlaSerLysGlyLyεLysAspAlaAlaLys-195 204-AsnArgLeuSerArg-208 673 AMPHI Regions - AMPHI 84-LeuAsnAspArgLeuAsnGlnAsnValThrGluAlaLeuGlyGlyValAspVal-101 110-ArgPheThrAspAla-114 117-ValValLeuLysGlnLeuProLys-124 172-ArgIleAlaAsnLeuLeuGluLeuIleLysProTyrLeu-184 212-LysLeuPheArgTyrLeuGlyGluGlu-220 261-GlyGluArgLeuLysLysIleSerThr-269 275-MetGluLysLeuPhe-279 285-LeuLysValTrpValLysValLys-292 Antigenic Index - Jameson-Wolf 7-LeuAlaGlyGluArgAlaAlaGlyGlyTyrArg-17 24-ValGlyArgProAsnValGlyLysSerThr-33 44-SerIleThrSerLysLysAlaGlnThrThrArgAsnArgValThr-58 61-TyrThrAspAspThrAla-66 73-ThrProGlyPheGlnThrAspHisArgAsnAlaLeuAsnAspArgLeuAsnGlnAsnValThrGlu-94 110-ArgPheThrAspAlaAspArgValVal-118 121-GlnLeuProLysHisThr-126 134-LysIleAspLysAspLysAlaLysAspArgTyrAla-145 153-ValArgAlaGluPhe-157 180-IleLysProTyrLeuProGluSerVal-188 190-MetTyrProGluAspMetValThrAspLysSerAlaArg-202 208-IleValArgGluLysLeuPhe-214 217-LeuGlyGluGluLeuPro-222 227-ValGluValGluGlnPheGluGluGluAspGlyLeuAsn-239 247-ValAspLysGluSerGlnLys-253 258-GlyLysGlyGlyGluArgLeuLysLysIleSerThrGluAlaArgLeuAspMetGluLysLeuPheAsp-2ϊ 0 291-ValLysSerGlyTrpAlaAspAspIleArgPheLeuArg-303 Hydrophilic Regions - Hopp-Woods 7-LeuAlaGlyGluArgAlaAlaGly-14 45-11eThrSerLysLysAlaGlnThrThr rgAsnArgVal-57 61-TyrThrAspAspThrAla-66 78-ThrAspHisArgAsnAlaLeuAsnAspArgLeuAsn-89 110-ArgPheThrAspAlaAspArgValVal-118 134-Lys11eAspLysAspLysAlaLysAspArgTyrAla-145 153-ValArgAlaGluPhe-157 194-AspMetValThrAspLysSerAlaArg-202 208-IleValArgGluLysLeuPhe-214 217-LeuGlyGluGluLeuPro-222 227-ValGluValGluGlnPheGluGluGluAspGlyLeuAsn-239 247-ValAspLysGluSerGlnLys-253 259-LysGlyGlyGluArgLeuLysLysIleSerThrGluAlaArgLeuAspMetGluLysLeuPheAsp-280 293-SerGlyTrpAlaAspAspIleArgPheLeuArg-303 674 AMPHI Regions - AMPHI 16-ValTyrGlnSerLeuIle-21 24-ThrAlaAlaProGluIleAlaLysAsnIleArgGluMetSerAspPheAlaLysAlaAspGluGluLeu-46 58-AlaAlaGluTyrIleArgGlnIleArgPro-67 86-ThrAlaCysHisGluLeuSerAlaMetProGluThr-97 107-IleGluValThrLysThrPheGlyGlyThrAεpGlyHisLysPheValAsnGlyIleLeuAspLysLeuAla -130 Antigenic Index - Jameson-Wolf l-MetLysThrAlaArgArgArgSerArgGluLeuAla-12 28-GluIleAlaLysAsnIleArgGluMetSerAspPheAlaLysAlaAspGluGluLeuPhe-47 54-ThrGlnThrAsnAla-58 63-ArgGlnIleArgProLeuLeuAspArgAspGluLysAspLeuAsnProIleGluArg-81 93-AlaMetProGluThrProTyr-99 105-GluAlaIleGluValThrLysThrPheGlyGlyThrAspGlyHisLysPhe-121 129-LeuAlaAlaGlnIleArgProAspGluProLysArgArg-141 Hydrophilic Regions - Hopp-Woods l-MetLysThrAlaArgArgArgSerArgGluLeuAla-12 28-GluIleAlaLysAsnIleArgGluMetSerAspPheAlaLysAlaAspGluGluLeuPhe-47 63-ArgGlnIleArgProLeuLeuAspArgAspGluLysAspLeuAsnProIleGluArg-81 105-GluAlaIleGluVal-109 133-11eArgProAspGluProLysArgArg-141 675 AMPHI Regions - AMPHI 21-ArgPheThrAsnGluIleGlySerGluMetLeuLysValCysCysArgThrLeuGlnGluLeuGly-42 74-AlaLeuIleAlaIle-78 123-GlnAlaIleGluArgIleGluGluLysAlaSerAsp-134 141-GluCysAlaAsnLeuValAsnLeuLeuLeuGlu-151 Antigenic Index - Jameson-Wolf 6-ProAsnLeuAspGlyLysHisLeuArg-14 26-IleGlySerGluMetLeu-31 42-GlyValAlaAspGluAsnIle-48 68-SerSerGluLysPheAsp-73 82-IleArgGlyGluThrTyr-87 92-ValSerAsnGluSerGlyAlaGlyVal-100 118-ThrGluAsnAspAlaGlnAlaIleGluArgIleGluGluLysAlaSerAspAlaAlaLysValAlaVal-14 0 152-GluGlnPheGluAspGluGlu-158 Hydrophilic Regions - Hopp-Woods 8-LeuAspGlyLysHisLeuArg-14 26-IleGlySerGluMetLeu-31 42-GlyValAlaAspGluAsnIle-48 68-SerSerGluLysPheAsp-73 82-IleArgGlyGluThrTyr-87 92-ValSerAsnGluSerGlyAlaGly-99 118-ThrGluAsnAspAlaGlnAlaIleGluArgIleGluGluLysAlaSerAspAlaAlaLysValAlaVal-14 0 152-GluGlnPheGluAspGluGlu-158 677 AMPHI Regions - AMPHI 20-AlaArgPheCysArgPheArgArg-27 45-LeuThrProPheArgArgValGlnAsnHisPheValAlaPheAlaArgPheAsnGln-63 79-IleAspPheIleAspAlaAsp-85 87-PheAspGlyLeuLeuAlaPro-93 105-LysHisLeuValGlyArgPhe-lll 155-CysArgProValAspAspLeuAspAspPheGlyAlaPhePheValAspGlnLeuIleLysLeuValPheGln Cys-179 Antigenic Index - Jameson-Wolf 23-CysArgPheArgArgHisSerArgSerValAsp-33 35-AspValPheAspArgLysAspPheAsn-43 47-ProPheArgArgValGln-52 61-PheAsnGlnThrThrSerGlnArgArgAsnProArgAsnPheVal-75 82-IleAspAlaAspAspPheAspGly-89 97-GlnGlnSerAspArgArgAlaGluLysHisLeu-107 115-GlyIleAspAspAspGlySerLeu-122 125-PheGlyGlnGluThrAspAlaAlaVal-133 156-ArgProValAspAspLeuAspAspPheGly-165 181-ProSerGlyGlyArgAsn-186 Hydrophilic Regions - Hopp-Woods 23-CysArgPheArgArgHisSerArgSerValAsp-33 35-AspValPheAspArgLysAspPhe-42 65-ThrSerGlnArgArgAsnProArg-72 82-IleAspAlaAspAspPheAsp-88 97-GlnGlnSerAspArgArgAlaGluLysHisLeu-107 115-GlyIleAspAspAspGlySer-121 126-GlyGlnGluThrAspAlaAlaVal-133 156-ArgProValAspAspLeuAspAsp-163 678 AMPHI Regions - AMPHI 10-LeuValSerAlaValIle-15 24-MetArgGlyValIle-28 80-IleGlnLysMetLeuArgSerLeuLeuThrSerAla-91 102-ArgIleLeuGlyGlyValPheGlyAlaLeu-lll 130-ProAspThrGluGlu-134 Antigenic Index - Jameson-Wolf 125-SerLysThrAspLeuProAspThrGluGluTrpArgGlnSerTyrThr-140 154-HisSerGlyGlyThrAlaGluThrProGluAspAsp-165 Hydrophilic Regions - Hopp-Woods 125-SerLysThrAspLeuProAspThrGluGluTrpArgGln-137 157-GlyThrAlaGluThrProGluAspAsp-165 681-2 AMPHI Regions - AMPHI 12-PheSerGluGluAlaLysPheIleSerAlaMet-22 120-CysLeuArgValGlyArgAlaValArgArg-129 Antigenic Index - Jameson-Wolf 9-AlaSerAsnPheSerGluGluAlaLysPhe-18 39-AlaThrProAsnSerTrpArgValArgGlnGln-49 59-LeuV 1LysArgAlaCys-64 67-ProMetArgArgCysLeuProSerArgLeu-76 90-GlyPheGlyMetProSerGluGly-97 102-AlaAlaSerArgArgArgPheGlyMetCysArgLeuArgGlnAlaProMetArgCysLeuArgValGlyArg AlaValArgArgPheGln-131 134-PheTrpArgCysArgArgGly-140 Hydrophilic Regions - Hopp-Woods ll-AsnPheSerGluGluAlaLysPhe-18 44-TrpArgValArgGln-48 59-LeuValLysArgAlaCys-64 67-ProMetArgArgCysLeuPro-73 102-AlaAlaSerArgArgArgPheGly-109 112-ArgLeuArgGlnAlaPro-117 119-ArgCysLeuArgValGlyArgAlaValArgArg-129 682-2 AMPHI Regions - AMPHI 33-ArgLeuArgLysCysGlyArgIleLeuSerGlyIleCysGluProPhe-48 99-CysArgLeuPheCysAspGly-105 Antigenic Index - Jameson-Wolf 9-SerTyrGlyLysTrpArgLysAsnTrpAspIle-19 30-SerSerThrArgLeuArgLysCysGlyArg-39 69-ArgThrLeuArgLeuArgGlySerArgThrArg-79 84-GlyProPheTrpPheCysHisArgProArgGlnSerHisGly-97 102-PheCysAspGlySerMetAspGlnThrArgAspArgArgCysArgSer-117 121-LeuHisSerAspArgTyrArgHisSerAsnLeuTrp-132 Hydrophilic Regions - Hopp-Woods 12-LysTrpArgLysAsnTrpAsp-18 32-ThrArgLeuArgLysCysGlyArg-39 69-ArgThrLeuArgLeuArgGlySerArgThr-78 91-ArgProArgGlnSerHisGly-97 105-GlySerMetAspGlnThrArgAspArgArgCysArgSer-117 122-HisSerAspArgTyrArgHis-128 683 AMPHI Regions - AMPHI 26-ThrProAspLysSerAlaArgTrpGluAsnIleGlyThrIleSerAsn-41 75-ArgPheAlaAsnThrPro-80 101-SerSerLeuGlnLeuPhe-106 124-ArgProMetSerIleLeuSerGly-131 Antigenic Index - Jameson-Wolf 24-CysSerThrProAspLysSerAlaArgTrpGluAsn-35 37-GlyThrIleSerAsnGly-42 48-11eAsnLysAspSerValArgLysAsnGlyAsn-58 63-GlnAspLysLysValValThrAsnLeuLysGlnGluArgPheAlaAsnThrProAlaTyr-82 93 -CysAsnAsnLysThrTyrArgLeu-100 106-PheAspThrLysAsnThrGluIleSerThrGlnAsnTyrThrAlaSerSerLeuArgPro-125 131-GlyThrLeuThrGluLysGlnTyrGlu-139 141-ValCysGlyLysLysLeu-146 Hydrophilic Regions - Hopp-Woods 25-SerThrProAεpLysSerAlaArgTrpGluAsn-35 48-1leAsnLysAspSerValArgLysAsnGly-57 63-GlnAspLysLysValValThr-69 71-LeuLysGlnGluArgPheAla-77 107-AspThrLysAsnThrGluIleSer-114 133-LeuThrGluLysGlnTyrGlu-139 141-ValCysGlyLysLysLeu-146 684 AMPHI Regions - AMPHI 13-AlaAlaCysGlyThrValGln-19 47-LeuAlaGluProLeu-51 73-TrpAlaAspThrLeuAspAspMetLeuGluAlaAlaLeuSerAsnAlaPheAsnArgLeuAspSerThr-95 110-TrpThrValTyrIleAspAlaPheGlnGlySerTyr-121 154-AlaMetThrAlaAlaLeuGluGlnGlyLeuLysGlnAlaAlaGlnGlnMetVal-171 Antigenic Index - Jameson-Wolf 26-LeuProAspSerArgTyrIleArgProAlaThrGlnGlyGlyGluThrAlaValGluValArgLeuAlaGluP roLeuLysArgGlyGlyLeu-56 60-ThrAspProTyrArgLeuAsnThrAlaGln-69 76-ThrLeuAspAspMetLeuGlu-82 90- snArgLeuAspSerThrArg-96 101-AlaSerArgSerGlySerThrGluLys-109 117-PheGlnGlySerTyrThrGlyLysThrLeu-126 133-LeuProAspGlyThrAsnArgProPheHisIleGluThrGluGlnGlnGlyAspGlyTyrAla-153 161-GlnGlyLeuLysGlnAlaAla-167 Hydrophilic Regions - Hopp-Woods 27-ProAspSerArgTyrIleArg-33 35-AlaThrGlnGlyGlyGluThrAlaValGluValArgLeuAlaGluProLeuLysArgGlyGly-55 76-ThrLeuAspAspMetLeuGlu-82 90-AsnArgLeuAspSer-94 102-SerArgSerGlySerThrGluLys-109 141-PheHisIleGluThrGluGlnGlnGlyAsp-150 161-GlnGlyLeuLysGlnAlaAla-167 685 AMPHI Regions - AMPHI 7-AsnPheAlaPheCysGlyValVal-14 44-CysAlaValLeuLeu-48 94-TrpAlaAlaLeuAspThrLeuThrGluLeu-103 137-TyrGluAlaLeuHisArgTyr-143 154-GlyAlaGluAlaTyrGluGlnLeuAlaLysAsn-164 182-GluLysGlnMetGluThrLeuAlaArgIlePheGlyLyεGlu-195 206-AspAlaLeuPheAla-210 296-AlaValGluValLeuAspAsnAlaLeuVal-305 336-AlaAlaGluGlnLeuLysAlaAla-343 Antigenic Index - Jameson-Wolf 20-LeuAsnAsnLysHisSerTyrSerTyrAlaLysGluProHisThrValLysProArgPhe-39 52-SerProGluProAlaAlaGluLysThrValSer-62 74-ProThrAlaArgGlyAspAlaValValProLysAsnProGluArgValAla-90 122-AlaPheAspLysAlaAla-127 133-PheGluProAspTyrGluAlaLeuHisArgTyrAsn-144 151-GlyGlyProGlyAlaGluAlaTyrGluGlnLeuAlaLysAsnAlaThr-166 170-LeuThrValAspAsnGlyAsnIleArgThrSerGlyGluLysGlnMetGluThrLeu-188 192-PheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnIle-205 211-GlnThrArgGluAlaAlaLysGlyLysGlyArgGlyLeu-223 227-ValThrGlyAsnLysValSerAlaPheGlyThrGlnSerArgLeu-241 247-GlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluGlyHisGlyGln-265 271-TyrIleLysGluLysAsnProAspTrpIle-280 285-ArgThrAlaAlaIleGlyGlnGluGlyProAla-295 307-GlyThrAsnAlaTrpLysArgLysGln-315 338-GluGlnLeuLysAlaAlaPheLysLysAlaGluPro-349 351-AlaAlaGlyLysLys-355 Hydrophilic Regions - Hopp-Woods 28-TyrAlaLysGluProHisThrValLys-36 52-SerProGluProAlaAlaGluLysThrValSer-62 75-ThrAlaArgGlyAspAlaValVal-82 84-LysAsnProGluArgValAla-90 122-AlaPheAspLysAlaAla-127 135-ProAspTyrGluAla-139 156-GluAlaTyrGluGlnLeuAlaLys-163 175-GlyAsnIleArgThrSerGlyGluLysGlnMetGluThrLeu-188 192-PheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnIle-205 211-GlnThrArgGluAlaAlaLysGlyLysGlyArgGly-222 253-ProValAspGluSerLeuArgAsnGluGlyHisGly-264 271-TyrIleLysGluLysAsnPro-277 290-GlyGlnGluGlyProAla-295 309-AsnAlaTrpLysArgLysGln-315 338-GluGlnLeuLysAlaAlaPheLysLysAlaGluPro-349 351-AlaAlaGlyLysLys-355 686-2 AMPHI Regions - AMPHI 7-ValLeuGlyGlyIleAlaAlaLeu-14 39-GlySerLeuIleGluArgIleAsnAεn-47 146-SerAsnIleLysSerIleAlaAspIleLysGlyValLysThrAlaGlnSerLeuThrSerAsnTyr-167 179-ValAlaValAspGlyLeuAlaGlnSerLeu-188 204-LeuAlaValLeuAspTyrLeuLysLysAsnPro-214 241-AspGluAlaValAlaLysPheSerThrAlaIle-251 255-LysAlaAspGlyThrLeuLysLysLeuGlyGluGlnPhe-267 Antigenic Index - Jameson-Wolf 20-GlyGlySerGluGlyGlySerGlyAlaSerSerAlaProAlaGlnSerAlaVal-37 40-SerLeuI1eGluArgl1eAsnAsnLysGlyThrVal-51 54-GlyThrGluGlyThr-58 64-TyrHisAspLysAspGlyLysLeuThrGlyTyrAspValGluValThrArgAlaValAlaGluLysLeuGlyV al-88 90-ValGluPheLysGluThrGlnTrp-97 118-LeuThrSerProGluArgGlnAlaThrPheAspLysSerAspProTyrSerTrp-135 143-ArgAsnAspSerAsnIleLysSerIleAlaAspIleLysGlyValLysThrAlaGln-161 163-LeuThrSerAsnTyrGlyGluLysAlaLysAlaAlaGly-175 191-IleGluGlnLysArgAlaAspAlaThrLeuAsnAspGluLeuAla-205 209-TyrLeuLysLysAsnProAsnAlaGly-217 225-ProAlaAspGluLysValGlySer-232 235-IleValAsnLysGlyAsnAspGluAlaValAla-245 252-AsnGluLeuLysAlaAspGlyThrLeuLysLysLeuGly-264 267-PhePheGlyLysAεpIleSerValGln-275 Hydrophilic Regions - Hopp-Woods 20-GlyGlySerGluGlyGlySerGly-27 41-LeuIleGluArgIleAsnAsn-47 64-TyrHisAspLysAspGlyLysLeuThrGlyTyrAspValGluValThrArgAlaValAlaGluLysLeuGlyV al-88 90-ValGluPheLysGluThrGlnTrp-97 120-SerProGluArgGlnAlaThrPheAspLysSerAspPro-132 143-ArgAsnAspSerAsnIle-148 150-SerIleAlaAspIleLysGlyValLysThr-159 167-TyrGlyGluLysAlaLysAlaAlaGly-175 191-IleGluGlnLysArgAlaAspAlaThrLeuAsnAspGluLeuAla-205 209-TyrLeuLysLysAsnProAsnAla-216 225-ProAlaAspGluLysValGly-231 238-LysGlyAsnAspGluAlaValAla-245 252-AsnGluLeuLysAlaAspGlyThrLeuLysLysLeuGly-264 687 AMPHI Regions - AMPHI H-AlaAlaLeuPheAlaLeu-16 64-LysValGluValLeuGluPhePheGlyTyrPheCysPro-76 78-CysAlaHisLeuGluProValLeuSerLysHisAlaLysSerPhe-92 112-LeuAlaArgLeuAlaAlaAla-118 148-ProGluValLeuLysLyεTrpLeu-155 176-GlnAlaArgAlaAspLysMetGlnGluLeuThrGluThrPhe-189 Antigenic Index - Jameson-Wolf l-MetLysSerArgHis-5 19-CysAspSerLysValGlnThrSerValProAlaAspSerAlaPro-33 43-GlyLeuValGluGlyGlnAsnTyr-50 56-ProIleProGlnGlnGlnAlaGlyLysValGluVal-67 87-LysHisAlaLysSerPheLysAspAspMetTyrLeu-98 122-AlaAlaAlaAspSerLysAspValAlaAsn-131 141-GlnLysIleLysLeuGlnAsnProGluValLeuLys-152 159-ThrAlaPheAspGlyLysLysVal-166 171-GluSerProGluSerGlnAlaArgAlaAspLysMetGlnGluLeuThrGlu-187 189-PheGlnIleAspGlyThrPro-195 199-ValGlyGlyLysTyrLysValGluPheAlaAsp-209 211-GluSerGlyMetAsnThr-216 220-LeuAlaAspLysValArgGluGluGlnLysAlaAlaGln-232 Hydrophilic Regions - Hopp-Woods l-MetLysSerArgHis-5 19-CysAspSerLysValGlnThr-25 27-ValProAlaAspSerAlaPro-33 61-GlnAlaGlyLysValGluVal-67 87-LysHisAlaLysSerPheLysAεpAspMetTyrLeu-98 122-AlaAlaAlaAspSerLysAspValAla-130 141-GlnLysIleLysLeuGlnAsn-147 159-ThrAlaPheAspGlyLysLysVal-166 171-GluSerProGluSerGlnAlaArgAlaAspLysMetGlnGluLeuThrGlu-187 201-GlyLysTyrLysValGluPheAlaAsp-209 220-LeuAlaAspLysValArgGluGluGlnLysAlaAlaGln-232 688 AMPHI Regions - AMPHI 23-LeuSerAlaLeuLeuGlyLeu-29 121-AspValLeuGlnAsnAlaAlaGluAlaLeuLysAsp-132 Antigenic Index - Jameson-Wolf 4-TyrProSerArgPheAlaGln-10 13-IleSerValAsnLys-17 33-SerAlaGluArgValSer-38 47-IleIleGlnGlyAsnGluLeuGluProArgAla-57 62-ArgProGlyMetThrLysAspGln-69 82-AlaPheHisThrAspArgTrpAspTyr-90 92-PheAsnThrSerArgAsnGlyIleIleLysGluArgSerAsnLeu-106 116-ValArgThrGluGlyAspVal-122 126-AlaAlaGluAlaLeuLysAspArgGlnAsnThrAspLysPro-139 Hydrophilic Regions - Hopp-Woods 33-SerAlaGluArgValSer-38 51-AsnGluLeuGluProArgAla-57 64-GlyMetThrLysAspGln-69 98-GlyIleIleLysGluArgSerAsn-105 116-ValArgThrGluGlyAεpVal-122 126-AlaAlaGluAlaLeuLysAspArgGlnAsnThrAspLysPro-139 689 AMPHI Regions - AMPHI 55-TyrProGluMetSerGluLysLeuMet-63 65-ValLeuMetAlaMetLeuValThrLeu-73 82-LeuProAlaIleProGluMetAlaGln-90 lll-AlaPheGlyGlnValValGlyGly-118 123-IleLysGlyArgLys-127 154-LeuAsnLeuArgValValGlnAlaPheGlyAlaGly-165 188-PheAlaLeuIleGlyIleIleLeu-195 203-ProMetValGlyAlaLeuLeuGlnGlyLeuGlyGlyTrpGlnAlaIlePheVal-220 230-LeuGlyLeuValGlnTyrPhe-236 245-LysIleGlyArgAspVal-250 257-ArgPheLysArgValLeu-262 277-SerPheGlySerMetPheAla-283 293-GlnGlnLeuTyrArgVal-298 344-AlaAlaAsnLeuSerGlnLeuAlaAlaValLeuPhe-355 400-ValLeuGlyValPheGlnSerLeuIleGly-409 Antigenic Index - Jameson-Wolf 36-PheArgArgArgAlaVal-41 45-IleGlyArgGluPheMetProSer-52 57-GluMetSerGluLysLeu-62 95-AspValHisArgIleGluGln-101 119-SerValSerAspIleLysGlyArgLysProVal-129 174-MetValArgAspTyrTyrSerGlyArgLysAlaAla-185 238-ProLysProAlaValGlyGlyLyεIleGlyArgAεpValPhe-251 257-ArgPheLysArgValLeuLysThrArgAla-266 325-LeuLysThrGlyValHis-330 390-PheLysGluGluGlyGlySer-396 448-ArgAlaTrpLysGluAsnGlyGlnSerGluTyrLeu-459 Hydrophilic Regions - Hopp-Woods 36-PheArgArgArgAlaVal-41 45-IleGlyArgGluPheMet-50 57-GluMetSerGluLysLeu-62 95-AspValHisArgIleGluGln-101 119-SerValΞerAspIleLysGlyArgLysProVal-129 178-TyrTyrSerGlyArgLysAlaAla-185 245-LysIleGlyArgAspVal-250 257-ArgPheLysArgValLeuLysThrArgAla-266 390-PheLysGluGluGlyGlySer-396 448-ArgAlaTrpLysGluAsnGlyGln-455 690 AMPHI Regions - AMPHI 38-SerSerAlaSerSerAla-43 54-SerAlaProAspAsnValLysGlnAla-62 68-SerAsnCysThrSerLeuHisProAlaThrGlyIleAspAspLeuMetGlnGlnIleAlaGluHisIle-90 113-GlyTyrAspAsnIleGlnArgLeu-120 148-ArgThrIleSerArgGlnAlaGlnAsnAla-157 186-ProLysArgThrArgTyrPhe-192 210-GlyAsnPheGlnTyrIleSerGlnLeuProGlyTyrLeuLys-223 Antigenic Index - Jameson-Wolf 1-MetLysAsnLysThrSer-6 20-CysSerProSerLysAspAspLysThrLysGluValGlyAla-33 37-SerSerSerAlaSerSerAlaProSerGlnThrAspLeuGlnProThrAlaSerAlaProAspAsnValLysG lnAlaGluSerAlaProProSerAsnCys-70 76-AlaThrGlyIleAspAspLeuMet-83 88-GluHisIleAspSerAspCys-94 101-HisGluLeuGluThrArgPheGlyLeuProAspGlyGlyTyrAspAsnIleGln-118 123-ProAspIleArgProGluAεpProAspTyrHisGln-134 141-GluAspLeuArgTyrGlyLysArgThrIleSerArgGlnAlaGln-155 159-MetGluGlnGluArgArgLeuArgGlu-167 175-GlySerGlnGluThrArgGlyGlnGlyGluGluProLysArgThrArgTyr-191 196-AlaThrProAlaTyrSerSerArgHisAsnAsnGlyLeuGlyGly-210 225-HisGlyGluMetLeuGluAsnGlnSerLeu-234 236-ArgLeuSerAsnArgGluArgAsnProAspLysProPheLeu-249 252-HisPheAspGluAsnGlyLysIleThr-260 264-ValTyrGluLysAεnIle-269 272-AsnProAsnThrGlyArgIle-278 Hydrophilic Regions - Hopp-Woods 1-MetLysAsnLysThr-5 21-SerProSerLysAspAspLysThrLysGluValGlyAla-33 39-SerAlaSerSerAlaProSerGlnThrAspLeuGlnPro-51 54-SerAlaProAspAsnValLysGlnAlaGluSerAlaPro-66 78-GlyIleAspAspLeuMet-83 88-GluHisIleAspSer-92 101-HisGluLeuGluThr-105 125-IleArgProGluAspProAspTyrHis-133 141-GluAspLeuArgTyrGlyLysArgThrIleSerArgGlnAlaGln-155 159-MetGluGlnGluArgArgLeuArgGlu-167 175-GlyΞerGlnGluThrArgGlyGlnGlyGluGluProLysArgThrArgTyr-191 200-TyrSerSerArgHisAsnAsn-206 225-HisGlyGluMetLeuGlu-230 237-LeuSerAεnArgGluArgAsnProAspLysProPhe-248 252-HisPheAspGluAsnGlyLysIleThr-260 274-AsnThrGlyArgIle-278 691 AMPHI Regions - AMPHI ll-LysProAlaAlaSer-15 55-HisAsnGluLeuArgLys11eArgThrAla-64 108-ArgTyrLeuSerGly-112 Antigenic Index - Jameson-Wolf 7-CysArgPheAlaLys-ll 35-ProProAsnAspPheGlnProAsnCysAspIleArgArgLeuGlyLeuThrGlnSerGlnHisAsnGluLeuA rgLys11eArgThr-63 67-Me AlaGlyAspArgAlaArgLeuLysValMetHis-78 80-GluHisSerArgArgArgSerVal-87 91-IleSerSerAspValPheAsnArgAsnGluAlaArgAspTyrValGluSerArgTyrLeuSerGlyMetAspP heAlaValAspGluLeuGluIle-122 131-ThrProGlnGlnGlnGln-136 140-SerSerCysLeuLys-144 Hydrophilic Regions - Hopp-Woods 43-CysAspIleArgArgLeuGly-49 54-GlnHisAsnGluLeuArgLysIleArgThr-63 67-MetAlaGlyAspArgAlaArgLeuLysValMetHis-78 80-GluHisSerArgArgArgSerVal-87 95-ValPheAsnArgAsnGluAlaArgAspTyrValGlu-106 115-PheAlaValAspGluLeuGluIle-122 692 AMPHI Regions - AMPHI 6-CysArgCysSerGluSerIleArgArgIleArgArgAsn-18 77-LeuGlyTyrValPheLysProLeuAlaValPheVal-88 106-GlnGlyPheGlyGlnLeuHis-112 132-ThrArgGlnLeuArgGlyPheLys-139 143-PheAspValPheGlnValLeuGly-150 170-GlnPheValGluHisHis-175 177-AspAlaGlyGluValGlyArgValValGlyArgGlyTyrGlyAlaAlaValPheAspPhePheGlnArgPhe GlnLeu-202 205-ValGlnSerGlnArgArgGlyArgHisLeuGluAspPheGlyAsp-219 253-IleValGlyLysLeuAspGlnPheAspGlyVal-263 275-PheAspHisIleAlaGluValAlaAsp-283 Antigenic Index - Jameson-Wolf 6-CysArgCysSerGluSerIleArgArgIleArgArgAsnGlyArgGluTrpArgIleLysGlyGlnLysCysAr gLeuAsnThrAspThrValGln-37 89-GlyGlyPheAspGlyArgProValAspIleGlyLysAlaArgPheLeu-104 120-AlaValAspAspGlyLysIle-126 131-AlaThrArgGlnLeuArgGlyPheLysLeuAspAspPheAsp-144 150-GlyAspValArgPheGlyCysGlyGlnArgIleAspAla-162 174-HisHisGlnAεpAlaGlyGluValGlyArgValValGlyArgGlyTyr-189 204-ArgValGlnSerGlnArgArgGlyArgHisLeuGluAspPheGlyAsp-219 236-GluAspValAspVal-240 255-GlyLysLeuAspGlnPheAspGly-262 279-AlaGluValAlaAspGlyArgAlaGluAspAspPhePhePhe-292 295-AlaValValGlyGlyGlyArgSerGlyCysGlyGlyArg-307 313-AlaAlaGlyGlyGluAspGluArgGluCysGlyGlyGlyLysGlyPheGluGlu-330 Hydrophilic Regions - Hopp-Woods 7-ArgCysSerGluSerIleArgArgIleArgArgAsnGlyArgGluTrpArgIleLysGlyGlnLysCysArgLe uAsnThr-33 91-PheAspGlyArgProValAspIleGlyLys-100 120-AlaValAspAspGlyLysIle-126 131-AlaThrArgGlnLeuArgGlyPheLysLeuAspAspPheAsp-144 174-HisHisGlnAspAlaGlyGluValGlyArgValValGly-186 206-GlnSerGlnArgArgGlyArgHisLeuGluAspPheGlyAsp-219 236-GluAspValAspVal-240 256-LysLeuAspGlnPheAsp-261 279-AlaGluValAlaAspGlyArgAlaGluAspAspPhePhePhe-292 299-GlyGlyArgSerGlyCysGlyGly-306 315-GlyGlyGluAspGluArgGluCysGlyGly-324 326-LysGlyPheGluGlu-330 694 AMPHI Regions - AMPHI 82- rgGlyArgAlaCysArg-87 116-CysArgHisPheAlaGln-121 123-ValAlaValGlyArgIleGly-129 140-PheCysGlnLeuPheAsp-145 156-AspIlePheLeuVal-160 162-IleAlaAspIleGlyGlu-167 184-ArgGlyLeuAlaAspIleGlyGluPheValGlyValSerAsp-197 251-HisGlnArgAlaSerArgIleLys-258 283-ArgAlaArgArgHisPheArgGlnValPheAsn-293 311-AspPheValAlaHisIle-316 340-AlaAlaArgIleGly-344 Antigenic Index - Jameson-Wolf 3-SerAlaSerGlyThrArgGlnLysCysArgLeuLysProVal-16 23-ProLysHisSerThrProAlaSer-30 47-GlyGlnAspGluHisAεnAla-53 66-ProProSerAlaTyrGly-71 79-HisPheGlyArgGlyArgAlaCysArgTyr-88 110-ArgIleAspSerAlaArgCysArgHis-118 127-ArgIleGlyArgThrAspHisAsnHisAsp-136 144-PheAspGlyGlyLeuProValGlyArgArgIleAla-155 163-AlaAspIleGlyGluThrArgValGlnArgGlyAspAspValPhe-177 180-IleAspArgGluArgGlyLeuAlaAsp-188 202-HisIleSerAspArgPheAspGlnLysHisPheAlaArgArgLysLeuProHisArgSerPheAspLeu-22 4 228-LeuMetProAspHisAspAspPheThr-236 250-ArgHisGlnArgAlaSerArgIleLysHisAlaGluThrAlaLeu-264 268-LeuProHisArgLeuArgTyrAla-275 280-AsnGlnCysArgAlaArgArgHisPhe-288 291-ValPheAsnLysHisArgThr-297 316-IleAsnArgArgAlaGluLeu-322 326-ThrPheAspAεnThrAspCysPro-333 336-ThrSerAlaGluAlaAlaArgIleGlyLysAspAspGlyPhe-349 370-TyrGlyGlyArgCysCysProThrProProThrProHisArgArgArg-385 Hydrophilic Regions - Hopp-Woods 5-SerGlyThrArgGlnLysCysArgLeuLysPro-15 47-GlyGlnAspGluHisAsnAla-53 81-GlyArgGlyArgAlaCysArg-87 110-ArgIleAspSerAlaArgCysArgHis-118 127-ArgIleGlyArgThrAspHisAsnHis-135 150-ValGlyArgArgIleAla-155 163-AlaAspIleGlyGluThrArgValGlnArgGlyAspAsp-175 180-IleAspArgGluArgGlyLeuAlaAsp-188 202-HisIleSerAspArgPheAspGlnLysHisPheAlaArgArgLysLeuProHisArgSerPheAspLeu-22 4 230-ProAspHisAspAsp-234 250-ArgHisGlnArgAlaSerArgIleLysHisAlaGluThrAlaLeu-264 280-AsnGlnCysArgAlaArgArgHisPhe-288 292-PheAsnLysHisArg-296 316-IleAsnArgArgAlaGluLeu-322 327-PheAspAsnThrAsp-331 338-AlaGluAlaAlaArgIleGlyLysAspAspGly-348 380-ThrProHisArgArgArg-385 695 AMPHI Regions - AMPHI 36-HisProGlnArgPheGlnSerLysProAlaGluArgProAlaHisArgPro-52 129-ValArgLeuSerAsnGluValGlu-136 144-AlaLeuGluHisAlaLysThrHisSer-152 156-AlaTyrValGlnLysLeuAsp-162 183-ValGluThrAlaGlnAsnLeuTyrAsnGlnAlaLeuLysHisTyrLysSerGly-200 205-AlaAlaSerLeuLeuLysGlyAla-212 238-CysGluSerValIleGluIle-244 248-TyrAlaAsnArgPheLysAspSer-255 278-AlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGly-291 Antigenic Index - Jameson-Wolf 1-LeuProGlnThrArgProSerArgArgHisHisArgHisArgGlnTyrPheAlaGluArgLysGlyAspAlaAr gSerGlyPhe-28 31-AlaAlaGlnArgArgHisProGlnArgPheGlnSerLysProAlaGluArgProAlaHisArgProHisHisP roAlaArgArgArgArgLeuAspProAlaSerGluLysIleMetLys-70 83-SerAlaSerCysAlaSer-88 93-ProAlaGlySerGlnThrGluMetSerThrArgGluAsnAlaSerAspGlyIleProTyr-112 117-LeuGlnAspArgLeuAspTyrLeuGlu-125 127-LysIleValArgLeuSerAsnGluValGluThrLeuAsnGlyLysValLysAlaLeuGluHisAlaLysThr HisSerSerGlyArgAlaTyrValGlnLysLeuAspAspArgLysLeuLysGlu-168 170-TyrLeuAsnThrGluGlyGlySerAla-178 193-AlaLeuLysHisTyrLysSerGlyLysPhe-202 209-LeuLysGlyAlaAspGlyGlyAspGlyGlySerIleAlaGln-222 230-GlnSerArgAlaArgMetGlyAsnCys-238 244-IleGlyGlyArgTyrAlaAsnArgPheLysAspSerProThrAlaPro-259 266-GlyGluCysGlnTyr-270 272-LeuGlnGlnLysAspIleAla-278 289-TyrProGlySerProAlaAlaLysArgAlaAlaAlaAlaValArgLysArg-305 Hydrophilic Regions - Hopp-Woods 2-ProGlnThrArgProSerArgArgHisHisArgHisArgGlnTyrPheAlaGluArgLysGlyAspAlaArgSe rGlyPhe-28 31-AlaAlaGlnArgArgHisProGlnArgPheGlnSerLysProAlaGluArgProAlaHisArgProHisHisP roAlaArgArgArgArgLeuAspProAlaSerGluLysIleMetLys-70 96-ΞerGlnThrGluMetSerThrArgGluAsnAlaSerAsp-108 117-LeuGlnAspArgLeuAspTyrLeuGlu-125 127-LysIleValArgLeuSerAsnGluValGluThrLeuAsnGlyLysValLysAlaLeuGluHisAlaLysThr HisSerSerGly-154 157-TyrValGlnLysLeuAspAspArgLysLeuLysGlu-168 195-LysHisTyrLysSerGlyLysPhe-202 210-LysGlyAlaAspGlyGlyAspGlyGlySerIleAlaGln-222 231-SerArgAlaArgMetGlyAsn-237 248-TyrAlaAsnArgPheLysAspSerProThrAlaPro-259 266-GlyGluCysGlnTyr-270 272-LeuGlnGlnLysAspIleAla-278 293-ProAlaAlaLysArgAlaAlaAlaAlaValArgLysArg-305 696 AMPHI Regions - AMPHI 18-PheGlyGlyIlePheHisPheValCysArgPheLeuSerArgValGlySerPheValGlnSerIlePheSerC ysPheSer-44 65-IlePheAspLeuValPhe-70 94-GlyLeuAsnArgPheLeuAsnLeuLeuPheGlyPheLeuArg-107 Antigenic Index - Jameson-Wolf 12-CysGlnGlyAsnLysLeu-17 73-PheAspGlyArgSerGlyArgLeuGlyGlyArgSerArgSer-86 108-ThrSerCysGlnGlySerArgHisHisCysGlyAsnGln-120 Hydrophilic Regions - Hopp-Woods 73-PheAspGlyArgSerGlyArgLeuGlyGlyArgSerArgSer-86 109-SerCysGlnGlySerArgHisHisCys-117 700 AMPHI Regions - AMPHI 6-ThrLeuLeuSerValLeuIleProMetPheAlaGlyPhePheIleArgValProLys-24 27-LeuProAlaLeuAspLysValLeuSerValLeu-37 51-ArgValGluAspLeuGlySerArg-58 80-AlaLeuAlaValLeuGlyLysLeu-87 119-PheGlyLysLeuMetArgAsp-125 191-SerTrpThrLysGlyLeu-196 204-TrpTyrSerLeuSerGlyLeuVal-211 216-TyrGlyAlaValTrp-220 228-AspLeuAlaArgGluLeu-233 268-GlyAlaGlyGlyLeu-272 Antigenic Index - Jameson-Wolf 21-ArgValProLysProTyrLeu-27 50-SerArgValGluAspLeuGlySerArgLeuAspAspMetAla-63 90-TrpArgl1eLysGlyLysGlyLysGlyVal-99 128MetProSerGluSerAlaGlyMetTyr-136 149-LeuLysSerSerGlyValSerLeu-156 160-LeuValAsnArgArgGlyIleArgLeu-168 185-AlaSerThrAspGlyValSer-191 245-ArgPheProAspAla-249 268-GlyAlaGlyGlyLeu-272 Hydrophilic Regions - Hopp-Woods 50-SerArgValGluAspLeuGlySerArgLeuAspAspMetAla-63 92-IleLysGlyLysGlyLysGlyVal-99 149-LeuLysSerSerGlyValSer-155 160-LeuValAsnArgArgGlyIleArg-167 701 AMPHI Regions - AMPHI 6-PheHisValAlaGly-10 30-CysLeuAspThrSer-34 45-ProAsnSerPheAlaSerPheLysArgPheSerSerIle-57 79-GlyProAlaProAlaMet-84 Antigenic Index - Jameson-Wolf 17-AlaGlnSerThrProSerSerProThrMet-26 29-ThrCysLeuAspThrSerProGluAlaGly-S* 52-LysArgPheSerSerIleSer-58 72-AsnArgAlaAspIleProThrGlyProAla-81 104-GlyLysAlaSerLeuAsnAsnArgAla-112 119-SerGlySerGlyThrArgLeu-125 Hydrophilic Regions - Hopp-Woods 72-AsnArgAlaAspIleProThr-78 702 AMPHI Regions - AMPHI 51-CysSerGlyLeuValThrVal-57 118-LysIleSerArgGly-122 Antigenic Index - Jameson-Wolf l-MetProCysSerLysAlaSer-7 28-LeuAlaArgAspSerCysSerProGlyLeu-37 41-ThrAlaProAlaSerSer-46 68-LeuAlaIleArgArgMetAlaSerArgProThrGlyValArgArgValIleSer-85 88-GlyMetProProSerThrArgAlaTrpAspLyεSerMetAla-101 118-LysIleSerArgGlyValSer-124 139-ArgTrpAspArgLeu-143 Hydrophilic Regions - Hopp-Woods 29-AlaArgAspSerCysSer-34 69-AlaIleArgArgMetAlaSerArgProThrGlyValArgArgValIleSer-85 94-ArgAlaTrpAspLys-98 139-ArgTrpAspArgLeu-143 703 AMPHI Regions - AMPHI 21-GlnThrLeuAlaThrValAsnGly-28 64-GluValValAsnThrValValAlaGlnGlu-73 79-LeuAspArgSerAlaGlu-84 140-AlaAlaTyrAspAsnIleSerGlyPheTyrLysGly-151 181-PheAspAlaValLeu-185 204-ValProLeuLysAspLeuGluGlnGlyValProProLeuTyrGlnAlaIleLysAspLeuLysLys-225 252-ValProSerPheAsp-256 270-ArgIleAspArgAlaValGlyAlaLeu-278 Antigenic Index - Jameson-Wolf l-MetLysAlaLysIle-5 26-ValAsnGlyGlnLysIleAspSerSerVal-35 43-PheArgAlaGluAsnSerArgAlaGluAspThrProGlnLeuArg-57 72-GlnGluValLysArgLeuLysLeuAspArgSerAlaGluPheLysAsnAlaLeuAlaLysLeuArgAlaGluA laLysLysSerGlyAspAspLysLysProSerPheLysThr-109 129-LysThrGlnProValSerGluGlnGluValLysAlaAlaTyr-142 144-AsnIleSerGlyPheTyrLysGlyThrGlnGluValGlnLeu-157 160-IleLeuThrAspLysGluGluAsnAlaLysLysAlaValAlaAspLeuLysAlaLysLysGlyPhe-181 188-TyrSerLeuAsnAspArgThrLysGlnThrGlyAlaProValGly-202 207-LysAspLeuGluGlnGlyValProPro-215 221-LysAspLeuLysLysGlyGluPheThrAlaThrProLeuLysAsnGlyAspPhe-238 243-TyrValAsnAspSerArgGluValLysValProSerPheAspGluMetLysGly-260 266-LeuGlnAlaGluArgIleAspArgAlaVal-275 282-AlaAsnIleLysProAlaLys-288 Hydrophilic Regions - Hopp-Woods l-MetLysAlaLysIle-5 29-GlnLysIleAspSerSerVal-35 43-PheArgAlaGluAsnSerArgAlaGluAspThrProGlnLeuArg-57 72-GlnGluValLysArgLeuLysLeuAspArgSerAlaGluPheLysAsnAlaLeuAlaLysLeuArgAlaGluA laLysLysSerGlyAspAspLysLysProSerPhe-107 131-GlnProValSerGluGlnGluValLysAlaAlaTyr-142 160-IleLeuThrAspLysGluGluAsnAlaLysLysAlaValAlaAspLeuLysAlaLysLysGlyPhe-181 189-SerLeuAsnAspArgThrLysGlnThrGly-198 207-LysAspLeuGluGln-211 221-LysAspLeuLysLysGlyGluPhe-228 245-AsnAspSerArgGluValLysValProSerPheAspGluMetLysGly-260 266-LeuGlnAlaGluArgIleAspArgAlaVal-275 282-AlaAsnIleLysProAlaLys-288 704 AMPHI Regions - AMPHI 33-GlyCysGlnAlaValAlaGlnSerIleIleAspAlaGlyLeuGly-47 65-GlnGluIleLeuAspGlnIleArgLeuTyrAspLeuProGluValGlnSerAspPheValGluThrHis-87 184-LeuGlyMetMetGln-188 208-LeuGlnIleLeuHisTrpGlyGlyPheLeuMetValLeuPro-221 232-GlnGlyAlaLeuArgAspLeuLys-239 252-AlaIleIleMetThrPheIleAlaGlyValTyrSer-263 289-PheMetGluHisIleAlaArg-295 298-AlaGlyAspAlaAlaGluArgLeuValLysLeuIleProAlaPheCysHisHisMetProAspTyrProAsp ThrGlnGluThr-325 400-GlyGlyThrArgLeuSerHisIleValArgLeuLeuAspArgAlaLeuAla-416 423-GluLeuAlaGluGlnTyr-428 499-AlaIleGluThrLeuAlaGln-505 527-IleSerLeuLeuArg-531 576-LeuAsnArgIleGlyGluGlyValGly-584 639-LeuLysAspSerAlaAlaGluAlaValArgGlnLeuAla-651 670-GluThrAlaArgAlaLeuGlyVal-677 691-GluTyrValLysAlaLeuGlnLysGlu-699 744-AspLeuArgThrValAlaHisLeuLeuAsp-753 780-AlaValLeuGlyTyrValGlnProTrpIleAlaAla-791 799-LeuAlaValLeuGly-803 805-AlaLeuArgLeuHisLysArg-811 Antigenic Index - Jameson-Wolf l-MetLysLysThrCys-5 8-CysGlyLeuAspValProGlu-14 21-ArgTyrGluAsnGluAspArgGluThrCysCys-31 46-LeuGlySerTyrTyrLysGlnArgThrAlaAspAlaGlnLysThrGluLeuProProGlnGluIleLeuAsp- 69 77-ProGluValGlnSerAspPheValGluThrHisGlyGlyThrArgGluAla-93 112-GlnLeuLeuArgThrAspGly11eVal-120 124-LeuAsnTyrSerThrHisArgCys-131 133-ValValTrpAspAspGlyLysIleArgLeu-142 158-ProTyrAspAlaGlnLysIleGluAlaAlaAsnGlnLysGluArgLysGlnTyr-175 199-TyrGlyGlyAspIleGluProAspPhe-207 234-AlaLeuArgAspLeuLysAsnArgArgValGlyMetAspThrProIle-249 293-IleAlaArgArgLysAlaGlyAspAlaAlaGluArgLeuVal-306 316-MetProAspTyrProAspThrGlnGluThrCysGlu-327 329-AlaValValLysLeuLysAlaGlyAsp-337 342-LysProGlyGluThrIleProValAspGlyThrVal-353 356-GlySerSerAlaValAsnGluSerMetLeuThrGlyGluSer-369 374-LysMetProSerGluLysValThrAla-382 393-11eArgThrAspArgThrGlyGlyGlyThrArg-403 414-AlaLeuAlaGlnLysProArgThrAlaGluLeuAlaGlu-426 486-ThrLeuAlaArgGluGlyIle-492 495-GlyGlyLysGlnAlaIle-500 510-11ePheAspLySThrGlyThrLeuThrGlnGlyLysProAlaValArgArg-526 528-SerLeuLeuArgGlyThrAspGluAlaPhe-537 545-LeuGluGlnGlnSerGluHisProLeu-553 560-CysArgIleSerAεpGlySerValPro-568 570-IleAlaIleLysGlnArgLeuAsnArgIleGlyGluGlyVal-583 589-ValAsnGlyGluThrGln-594 605-AlaGluIleSerGlyLysGluProGlnThrGluGlyGlyGlySer-619 637-AspProLeuLysAspSerAlaAlaGluAlaValArg-648 650-LeuAlaGlyLysAsnLeu-655 659-IleLeuSerGlyAspArgGluThrAlaVal-668 684-AlaMetProGluAspLysLeuGluTyr-692 694-LysAlaLeuGlnLysGluGlyLysLys-702 707-GlyAspGlyIleAsnAspAla-713 725-AlaAlaGlyGlyThrAspIleAlaArgAspGlyAlaAsp-737 743-GluAspLeuArgThr-747 753-AspGlnAlaArgArgThrArgHisIleIle-762 807-ArgLeuHisLysArgGlyLysMetGlnSerGluLysMetProSerGluGln-823 Hydrophilic Regions - Hopp-Woods l-MetLysLysThrCys-5 21-ArgTyrGluAsnGluAspArgGluThrCys-30 50-TyrLysGlnArgThrAlaAspAlaGlnLysThrGluLeuProPro-64 77-ProGluValGlnSerAspPheValGlu-85 87-HisGlyGlyThrArgGluAla-93 112-GlnLeuLeuArgThrAspGlyIleVal-120 133-ValValTrpAspAspGlyLysIleArgLeu-142 160-AspAlaGlnLysIleGluAlaAlaAsnGlnLysGluArgLysGlnTyr-175 201-GlyAspIleGluProAspPhe-207 234-AlaLeuArgAspLeuLysAsnArgArgValGlyMet-245 293-IleAlaArgArgLysAlaGlyAspAlaAlaGluArgLeuVal-306 318-AspTyrProAspThrGlnGluThrCysGlu-327 329-AlaValValLysLeuLysAlaGlyAsp-337 374-LysMetProSerGluLysValThr-381 393-1leArgThrAspArgThrGlyGlyGlyThrArg-403 414-AlaLeuAlaGlnLysProArgThrAlaGluLeuAlaGlu-426 486-ThrLeuAlaArgGluGlyIle-492 518-ThrGlnGlyLysProAlaValArgArg-526 531-ArgGlyThrAspGlu-535 545-LeuGluGlnGlnSerGluHisProLeu-553 561-ArgIleSerAspGlySerVal-567 570-IleAlaIleLyεGlnArgLeuAsnArgIleGlyGlu-581 607-IleSerGlyLysGluProGlnThrGluGlyGlyGly-618 638-ProLeuLysAspSerAlaAlaGluAlaValArg-648 661-SerGlyAspArgGluThrAlaVal-668 684-AlaMetProGluAspLysLeuGluTyr-692 694-LysAlaLeuGlnLysGluGlyLysLys-702 730-AspIleAlaArgAspGlyAlaAsp-737 743-GluAspLeuArgThr-747 753-AspGlnAlaArgArgThrArgHisIleIle-762 807-ArgLeuHisLysArgGlyLysMetGlnSerGluLysMetProSerGluGln-823 705 AMPHI Regions - AMPHI 67-LysIleLeuLeuLysLeu-72 104-AspProIleProAla-108 147-TyrMetGlnThrPheArgArgIleValAlaProGln-158 169-AsnGluPheIleGlyLeuPheLysAsn-177 183-ValValThrValThrGluLeuPheArgValAlaGln-194 196-ThrAlaAsnArgThr-200 Antigenic Index - Jameson-Wolf 13-ThrGluThrArgAlaAspMet-19 132-ValProLysGlyGlnTrpGlu-138 165-ProProLeuSerAsnGlu-170 193-AlaGlnGluThrAlaAsnArgThrTyrAsp-202 226-AlaArgLeuGluLysArgPheAspArgTyrValAla-237 Hydrophilic Regions - Hopp-Woods 13-ThrGluThrArgAlaAspMe -19 193-AlaGlnGluThrAlaAsnArgThr-200 226-AlaArgLeuGluLysArgPheAspArgTyrValAla-237 706 AMPHI Regions - AMPHI 9-LeuValSerArgTrpLeuAsnSerTyr-17 24-ArgLeuIleHisAlaValArg-30 70-IleTyrSerLysAlaValGluArgMetLeuGlyThrValIleGly-84 Hl-ThrAlaSerAlaLeuAlaGlyTrpAlaAla-120 153-ArgAlaMetAsnValLeu-158 183-LeuAlaAspAsnLeuAlaAspCysSerLysMetIleAlaGluIleSerAsnGlyArg-201 204-ThrArgGluArgLeuGluGluAsn-211 243-MetGluAlaMetGlnHisAlaHisArgLysIleVal-254 318-AlaLeuAlaGluHisLeuHis-324 Antigenic Index - Jameεon-Wolf l-MetAsnThrSerGlnArgAsnArgLeu-9 H-SerArgTrpLeuAsnSerTyrGluArgTyrArgTyrArgArg-24 73-LysAlaValGluArgMetLeu-79 97-HisTyrPheHisGlyAsnLeu-103 122-GlyLysAsnGlyTyrVal-127 140-GlyAspAsnGlySerGluTrpLeuAsp-148 186-AsnLeuAlaAspCysSerLysMetIleAlaGluIleSerAsnGlyArgArgMetThrArgGluArgLeuGlu GluAsnMetAlaLysMetArgGlnIleAsn-219 221-ArgMetValLysSerArgSerHisLeuAlaAlaThrSerGlyGluSerArgIleSer-239 249-AlaHisArgLysIleValAsn-255 266-LysLeuGlnSerProLysLeuAsnGlySerGluIleArgLeuLeuAsp-281 300-GlyArgHisAlaArgArgIleArgIleAspThrAlaIleAsnProGluLeuGluAlaLeuAla-320 334-SerThrAsnMetArgGlnGluIle-341 349-GlnArgThrArgArgLysTrpLeuAspAlaHisGluArgGlnHisLeu-364 367-SerLeuLeuGluThrArgGluHisGly-375 Hydrophilic Regions - Hopp-Woodε 3-ThrSerGlnArgAsnArgLeu-9 17-TyrGluArgTyrArgTyrArgArg-24 73-LysAlaValGluArgMetLeu-79 142-AsnGlySerGluTrpLeu-147 186-AsnLeuAlaAspCysSerLysMetIleAla-195 198-SerAsnGlyArgArgMetThrArgGluArgLeuGluGluAsnMetAlaLysMetArgGlnIleAsn-219 221-ArgMetValLysSerArgSerHis-228 232-ThrSerGlyGluSerArgIle-238 249-AlaHisArgLysIleValAsn-255 266-LysLeuGlnSerProLysLeuAsnGlySerGluIleArgLeuLeuAsp-281 301-ArgHisAlaArgArgIleArgIle-308 314-ProGluLeuGluAlaLeuAla-320 336-AsnMetArgGlnGluIle-341 349-GlnArgThrArgArgLysTrpLeuAspAlaHisGluArgGlnHisLeu-364 367-SerLeuLeuGluThrArgGluHisGly-375 707 AMPHI Regions - AMPHI 9-LeuIleArgSerMetGlnArgGln-16 88-AsnLeuSerArgLeuGlnLysAla-95 170-GluGlnGlyLeuGluAsnLeuArgArgLeuProSerVal-182 219-GlyGlyLysThrThrGlyLysTyr-226 241-SerAspLeuPheTyr-245 294-ArgTyrHisGluAlaThrGlu-300 339-ThrArgGlnThrTyrLysTyrIleAspAsp-348 539-HisLysProLysGlyPheGlnThrThrAsnThr-549 Antigenic Index - Jameson-Wolf 3-IleIleAsnAspAlaGluLeuIleArgSerMetGlnArgGlnGlnHisIleAsp-20 27-AlaAsnValArgPheGluGlnProLeuGluLysAsnAsnTyrValLeuSerGluAspGluThrProCysThrA rg-51 56-SerLeuAspAspLysThrValArg-63 85-GlySerAsnAsnLeuSerArgLeuGlnLysAlaAla-96 114-ProGlnAsnMetAspSerGlyIleLeu-122 125-ArgValΞerAlaGlyGluIleGlyAspIleArgTyrGluGluLysArgAspGlyLysSerAlaGluGlySer Ile-149 157-ProLeuTyrArgAsnLys11eLeuAsn-165 167-ArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSerValLysThrAspIle-186 189-IleProSerGluGluGluGlyLysSerAspLeu-199 202-LysTrpGlnGlnAsnLysProIleArg-210 213-IleGlyIleAspAspAlaGlyGlyLysThrThrGlyLysTyrGlnGly-228 235-AspAsnProLeuGly-239 248-TyrGlyArgGlyLeuAlaHisLyεThrAspLeuThrAspAlaThrGlyThrGluThrGluSerGlySerArg SerTyr-273 288-PheAsnHisAsnGlyHisArgTyrHisGluAlaThrGluGlyTyrSerValAsnTyrAspTyrAsnGlyLys GlnTyrGln-314 322-MetLeuTrpArgAsnArgLeuHisLysThrSerVal-333 341-GlnThrTyrLysTyrIleAspAspAlaGluIleGluValGlnArgArgArgSerAlaGlyTrpGluAlaGlu LeuArgHis-367 374-TrpGlnLeuAspGlyLysLeuSerTyrLysArgGlyThrGlyMetArgGlnSerMetProAlaProGluGlu AsnGlyGlyAspIleLeuProGlyThrSerArgMetLysIle-411 438-GlnTrpAsnLysThrPro-443 446-AlaGlnAspLysLeuSerIleGlySerArgTyrThrValArgGlyPheAspGlyGluGlnSerLeuPheGly GluArgGlyPheTyrTrpGlnAsnThr-478 493-AlaAspTyrGlyArgValSerGlyGluSerAla-503 506-ValSerGlyLysGln-510 518-PheArgGlyGlyHisLysValGly-525 536-LysProLeuHisLysProLysGlyPheGln-545 Hydrophilic Regions - Hopp-Woods 3-IleIleAsnAspAlaGluLeuIleArgSerMetGlnArgGlnGlnHisIleAsp-20 27-AlaAsnValArgPheGluGlnProLeuGluLysAsnAsn-39 42-LeuSerGluAspGluThrProCys-49 56-SerLeuAspAspLysThrValArg-63 88-AsnLeuSerArgLeuGlnLysAlaAla-96 130-GluIleGlyAspIleArgTyrGluGluLysArgAspGlyLysSerAlaGluGlySer-148 167-ArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSerValLysThrAspIle-186 190-ProSerGluGluGluGlyLysSerAspLeu-199 213-IleGlyIleAspAspAlaGlyGlyLysThrThrGlyLysTyr-226 252-LeuAlaHisLysThrAspLeuThrAsp-260 262-ThrGlyThrGluThrGluSerGlySerArgSer-272 294-ArgTyrHisGluAlaThrGlu-300 345-TyrIleAspAspAlaGluIleGluValGlnArgArgArgSerAlaGlyTrp-361 363 -AlaGluLeuArgHis-367 378-GlyLysLeuSerTyrLysArgGlyThrGlyMetArgGlnSerMetProAlaProGluGluAsnGlyGly-40 0 407-SerArgMetLysIle-411 446-AlaGlnAspLysLeuSerIle-452 460-GlyPheAspGlyGluGln-465 494-AspTyrGlyArgValSerGlyGluSer-502 537-ProLeuHisLysProLysGly-543 708 AMPHI Regions - AMPHI 26-ProSerArgAlaGluLysAlaAsnGlnValSerAsnIle-38 56-ThrAlaSerIleGluAspAlaLeuLysSerAspPro-67 79-IleTyrGlnTyrLeuLys-84 89-AlaGlnGluSerPhe-93 119-AsnArgProAlaGluSerMetAla-126 128-PheAspLysAlaLeu-132 142-IleAlaAsnLeuAsnLys-147 176-ProAlaPheLysGluLeuAlaArg-183 221-LysAlaLeuGlyAsnAlaGln-227 Antigenic Index - Jameson-Wolf 2-ProPheLysProSerLysArgIleSer-10 19-AlaCysSerThrSerTyrArgProSerArgAlaGluLysAlaAsnGln-34 46-TyrMetArgGlyGlnAspTyrArgGlnAlaThrAlaSerIleGluAεpAlaLeuLysSerAspProLysAsnG lu-70 84-LysValAsnAspLysAlaGlnGluSerPheArg-94 97-LeuSerIleLysProAspSerAlaGluIleAsnAsnAsnTyrGlyTrp-112 115-CysGlyArgLeuAsnArgProAlaGlu-123 131-AlaLeuAlaAspProThrTyrProThr-139 145-LeuAsnLysGlyIleCysSerAlaLysGlnGlyGln-156 176-ProAlaPheLysGluLeuAlaArgThrLysMet-186 191-LeuGlyAspAlaAspTyrTyrPheLysLysTyrGlnSerArgValGluValLeuGlnAlaAspAspLeu-21 3 240-PheProTyrSerGluGluLeuGln-247 Hydrophilic Regions - Hopp-Woods 4-LysProSerLysArgIle-9 24-TyrArgProSerArgAlaGluLysAlaAsnGln-34 46-TyrMetArgGlyGlnAspTyrArgGln-54 56-ThrAlaSerIleGluAspAlaLeuLysSerAspProLysAsnGlu-70 84-LysValAsnAspLysAlaGlnGluSerPheArg-94 99-IleLysProAspSerAlaGluIle-106 117-ArgLeuAsnArgProAlaGlu-123 149-IleCysSerAlaLysGlnGly-155 177-AlaPheLysGluLeuAlaArgThrLysMet-186 201-TyrGlnSerArgValGluValLeuGlnAlaAspAspLeu-213 709 AMPHI Regions - AMPHI 6-SerLeuLeuAspMetProArgGlyGlu-14 18-ValValValAlaLeuIleAlaAlaMetGly-27 37-ProHisMetSerIleIleAlaAlaIleValValLeu-48 54-AlaArgGlyLeuLysTyrAsn-60 64-GlnGlyMetIleGlyAlaLeuAsnGlnGly-73 115-ΞerSerPheAlaLeuCysSerVal-122 130-SerLeuThrThrCysAla-135 171-ProLeuSerAspThr-175 185-IleAspLeuPheGluHisIleLysAsnMetMetTyrThrThr-198 221-LeuAsnSerValGluSerPheArg-228 253-LeuMetArgIleAsnAla-258 261-AlaMetLeuPheThr-265 278-ThrProAspLeuArgGlnLeuGlyAlaTrpPhe-288 298-AlaPheLysAspValValLysLeuIleSerArgGlyGly-310 334-LeuGlyValIleProSerLeuLeuGluAlaIleArgThrPheLeuThr-349 382-ThrPheLysProVal-386 395-ArgAsnLeuSerArgThrLeuGluAspAlaGlyThrValIleAsnProLeuValProTrpSerValCysGly ValPheIleSerHis-423 Antigenic Index - Jameson-Wolf 8-LeuAspMetProArgGlyGluAla-15 55-ArgGlyLeuLysTyrAsnAspMetGln-63 165-PheGlyAεpLysMetSerProLeuSerAspThrThrGly-177 222-AsnSerValGluSerPheArgSerGlnLeuGlu-232 277-SerThrProAspLeuArgGln-283 290-GlyGlyTyrLysLeuGluGlyGluAlaPheLysAspValVal-303 306-IleSerArgGlyGlyLeuGlu-312 378-LeuSerGlyGluThrPheLysProValTyrAspLysLeuGlyLeuHisSerArgAsnLeuSerArgThrLeu GluAspAlaGlyThr-406 Hydrophilic Regions - Hopp-Woods 8-LeuAspMetProArgGlyGluAla-15 57-LeuLysTyrAsnAspMetGln-63 168-LysMetSerProLeuSerAsp-174 225-GluSerPheArgSerGlnLeuGlu-232 279-ProAspLeuArgGln-283 293-LysLeuGluGlyGluAlaPheLysAspValVal-303 396-AsnLeuSerArgThrLeuGluAspAlaGly-405 710 AMPHI Regions - AMPHI 6-LysIleArgLeuMetArgGluLeuAsnLysTrpSerGln-18 31-GlyTyrAlaLysIleGlu-36 45-ProArgLeuGluGlnLeuAlaGlnIlePheLysIleAspMetTrpAspLeuLeuLys-63 104-CysLysGluMetLeuGlu-109 Antigenic Index - Jameson-Wolf 1-MetGluThrHisGluLysIleArgLeuMetArgGluLeuAsnLysTrpSerGlnGluAspMetAlaGluLysLe uAla-26 33-AlaLysIleGluArgGlyGluThrGlnLeuAsnIleProArgLeuGluGln-49 62-LeuLysSerGlyGlyGlyGly-68 73-IleAsnGluGlyAspSerGlyGlyAsp-81 86-AlaSerGlyAspValSerMet-92 95-GluPheLeuLysMetGluLeuLysHisCysLysGluMetLeuGluGlnLysAspLysGluIleGluLeuLeuA rgLysLeuThrGlu-123 Hydrophilic Regions - Hopp-Woods 1-MetGluThrHisGluLysIleArgLeuMetArgGluLeuAsnLysTrpSerGlnGluAspMetAlaGluLysLe uAla-26 33-AlaLysIleGluArgGlyGluThr-40 45-ProArgLeuGluGln-49 74-AsnGluGlyAspSerGlyGly-80 95-GluPheLeuLysMetGluLeuLysHisCysLysGluMetLeuGluGlnLysAspLysGluIleGluLeuLeuA rgLysLeuThrGlu-123 711 AMPHI Regions - AMPHI 28-AlaGluSerTyrArgAsnLeuThrAlaSerGluIleAlaLysValTyrThrIleAlaArgMetThrAspLeuA spMetLeuAsnAspIleLys-58 67-SerGlyGlnSerPheAspAspTrpArgLysGlyIleLeu-79 95-GlyLysAspIleIleAspProAlaThrGlyGluValPheGlySerProArgArgLeuGluThrIleTyrArgT hrAsnMet-121 128-GlyGlnTyrGlnGlyTyrMet-134 158-SerAlaIleAspGly-162 195-ValGluArgGlnGly-199 203-GlyGlnSerThrAlaAspAsnLeuValGluThrHis-214 258-LysTyrAspArgAlaLeuAlaHisGlnPheAla-268 281-PheLysGlnLeuGluLysGluPheTyr-289 329-GlnGluLeuAlaGlyMetThr-335 352-SerArgGluGlyGlnAsnPhe-358 360-AspSerTyrTyrAlaPheLeuProAspMetLeuGlnAsnProGlu-374 395-TrpAlaValLeuLysTyrIleLysGluValAspGluIle-407 413-ArgIleSerAsnAspLysGluIleAlaLys-422 Antigenic Index - Jameson-Wolf ll-SerLeuProProLysLysAlaIleGlu-19 21-LeuGluSerLysLysValThrAlaGluSerTyrArgAsnLeuThr-35 55-AsnAspIleLysThrSerMet-61 63-GluSerAlaLysSerGlyGlnSerPheAspAspTrpArgLysGlyIle-78 82-LeuSerAsnLysGlyTrpLeuHisProAsnGlyHisAsnGlyLysAspIleIleAspProAlaThrGlyGluV alPheGlySerProArgArgLeuGluThrlleTyrArgThrAsnMet-121 126-AsnAlaGlyGlnTyrGlnGly-132 135-AlaAsnIleAspAlaArgProTyrTrp-143 147-AlaValGlyAεpSerArgThrArgProAlaHiεSerAla-159 165-TyrArgTyrAspAspProPheTrp-172 177-ProProAsnGlyTyrAsnCysArgCysSer-186 190-LeuSerGluArgAspValGluArgGlnGlyArgIleValGlyGlnSerThrAlaAspAsnLeuValGlu-21 2 215-LysIleTyrAsnLysLysGlyAspThr-223 229-TyrLysAlaProAspGlySerLeuTyrThrThrAspArgGlyPheAspTyrAsnAlaGlyArgMetAsnTyr ArgProAspLeuAspLysTyrAspArgAlaLeu-263 268-AlaLysAlaGluMetGlyGlyAlaAspPheLysThrSerPheLysGlnLeuGluLysGluPheTyrGluVal LysGlnArgLeuAspI1eAspGlyLysProAspLysGluGlnLysIleLys11eArgAsnAlaLeu-313 324-LeuSerLysGluThrGlnGlu-330 342-SerAspAspThrLeuValLysGlnValAspSerArgGluGlyGlnAsnPheAspAspSerTyrTyr-363 370-LeuGlnAsnProGluHisValIleArgAspAsnArgGlu-382 387-AlaArgTyrLysGlySer-392 400-TyrIleLysGluValAspGlu-406 411-SerTyrArgIleSerAsnAspLysGluIleAla-421 424-MetAlaLysLysLysValLeuLys-431 Hydrophilic Regions - Hopp-Woods 13-ProProLysLysAlaIleGlu-19 21-LeuGluSerLysLysValThrAlaGluSerTyrArg-32 55-AsnAspIleLysThrSerMet-61 63-GluSerAlaLysSerGlyGlnSerPheAspAspTrpArgLys-76 93-HisAsnGlyLysAspIleIleAsp-100 108-GlySerProArgArgLeuGluThr-115 147-AlaValGlyAspSerArgThrArgProAlaHisSerAla-159 190-LeuSerGluArgAspValGluArgGlnGlyArgIleVal-202 215-LysIleTyrAsnLysLysGlyAspThr-223 238- hrThrAspArgGlyPheAsp-244 250-MetAsnTyrArgProAspLeuAspLysTyrAspArgAlaLeu-263 268-AlaLysAlaGluMetGlyGlyAlaAspPheLysThrSerPheLysGlnLeuGluLysGluPheTyrGluVal LysGlnArgLeuAspIleAspGlyLysProAspLysGluGlnLysIleLysIleArgAsnAlaLeu-313 324-LeuSerLysGluThrGlnGlu-330 344-AspThrLeuValLysGlnValAspSerArgGluGlyGlnAsnPheAsp-359 375-HisValIleArgAspAsnArgGlu-382 400-TyrIleLysGluValAspGlu-406 414-IleSerAsnAspLysGluIleAla-421 424-MetAlaLysLysLysValLeuLys-431 712 AMPHI Regions - AMPHI 12-GlySerIleArgVal-16 29-ValGlnGlyLeuProGlnAsnPro-36 55-GluProValGlnLeuPhe-60 72-GlySerLeuAlaHisLeuMet-78 131-SerThrAlaValAsn-135 142-ThrValAlaAspArgLeuLys-148 210-ThrAlaLeuSerLysValAla-216 231-AlaAsnAlaLysAlaLeuSerAsnHisIleThrAsnValSerAsnAlaIle-247 306-ProAlaLysProLeuAsnThrLeuGlu-314 329-PheAlaGluCysAsnAsnAlaLeuTyrAsnGlyLeuThrProLeu-343 352-IleMetArgAlaValSerThrTyrThrLysSerAlaAsnAsn-365 374-1leThrThrIleArgThrLeuAspTyrValArgArgSerVal-387 411-GluIleLeuAspValLeuIle-417 421-GlnAlaGluIleIleGluAsn-427 441-GlnAsnAspProAsn-445 454-AspValValAsnGlyLeu-459 Antigenic Index - Jameson-Wolf 6-AspPheAspThrIleProGlySerIleArgValProGlyGln-19 23-PheAsnThrArgAsnAlaVal-29 32-LeuProGlnAsnProGlnLys-38 61-SerAspAlaGluAlaAlaAsp-67 125-IleGlyGlyLysGlnVal-130 134-ValAsnThrGlyGluThrAla-140 143-ValAlaAspArgLeuLysThr-149 171-AlaLysHisLysGlyGluIleGlyAsnGluSerGlyLeu-183 201-GlyGlyAlaLysAsnAlaAsp-207 215-ValAlaGlyLysHis-219 225-SerProPheSerAspAspAlaAsnAlaLysAlaLeuSer-237 243-ValSerAsnAlaIleGluGlnArgGlyCys-252 268-AlaThrGlyGluIleAsnAspGlyArgMet-277 284-GlyAlaValGluProAsnGly-290 302-PheGluGluAspProAlaLysProLeuAsn-311 313-LeuGluIleLysGly-317 320-ValThrProAspAlaGln-325 332-CysAsnAsnAlaLeuTyrAsnGly-339 358-ThrTyrThrLysSerAlaAsnAsnThrAspAspProAlaLeu-371 381-AspTyrValArgArgSerValLysGluArgIleAlaLeuArgPheProArgAspLysLeuSerAspArgLeu LeuProLysValLysSerGluIle-412 419-LeuAspGlnAlaGluIleIleGluAsnAlaGluAlaAsnLysGlyLysLeuValVal-437 440-AlaGlnAsnAspProAsnArgValAsnAla-449 Hydrophilic Regions - Hopp-Woods 61-SerAspAlaGluAlaAlaAsp-67 135-AsnThrGlyGluThr-139 143-ValAlaAspArgLeuLysThr-149 171-AlaLyεHisLysGlyGluIleGlyAsn-179 203-AlaLysAsnAlaAsp-207 227-PheSerAspAspAlaAsnAlaLysAlaLeu-236 247-IleGluGlnArgGly-251 270-GlyGluIleAsnAspGlyArgMet-277 302-PheGluGluAspProAlaLysPro-309 313-LeuGluIleLysGly-317 362-SerAlaAsnAsnThrAspAspProAlaLeu-371 381-AspTyrValArgArgSerValLysGluArgIleAla-392 395-PheProArgAspLysLeuSerAspArgLeuLeuProLysValLysSerGluIle-412 419-LeuAspGlnAlaGluIleIleGluAsnAlaGluAlaAsnLysGlyLysLeuValVal-437 440-AlaGlnAsnAspProAsnArg-446 713 AMPHI Regions - AMPHI 18-GluHisArgHisTrpGlu-23 115-AspAlaAlaLysLysLeuAlaAlaProTrpProGlnIle-127 150-ThrValTrpGlnAlaLeuThrHisIleAlaAεnSerVal-162 257-AspAsnLeuAlaAlaLeuGln-263 265-GlnAlaLysLysGln-269 Antigenic Index - Jameson-Wolf l-MetGlnAsnAsnSerTyrGly-7 13-ArgValGlyGlyLysGluHisArgHisTrpGluArgTyrAspIleAspSerAspPhe-31 44-ArgLeuGlyProGluAlaAlaIleProAspLeuSerGlyGluSerCysGluValValIle-63 74-GlySerGlnArgHisGlyLysSerLysGlySerArgGluLeuSerLeuSerGlyArgAspLeu-94 106-LeuAsnValLysGly-llO 115-AspAlaAlaLysLysLeu-120 131-ValLeuLysAlaGluAsnAsnProAlaLeuGlyLysIleAspIleGluProGlyGlu-149 167-TrpLeuGluProAspGlyThrLeu-174 177-GlyGlyAlaAspTyrSerSerProPro-185 192-SerArgThrAspSerArgCysAsnIleGluArgMetAspIleGluTrpAspThrAspAsnArgPheSerGlu -215 222-SerHisGlyArgSerGlyAspSerAlaLysHisAspLeu-234 237-ValTyrLysAspProThrMetThrLeuHisArgProLysThrValVal-252 254-ΞerAspAlaAspAsn-258 263-GlnLysGlnAlaLysLysGlnLeuAla-271 284-ValGlyGlyHisLysThrArgAspGly-292 303-ValIleAspAspGluHisGlyIle-310 321-PheMetLeuSerArgMetAspGlyThrGlnThrGluLeuArgLeuLysGluAspGlyIleTrpThrProAsp AlaTyrProLysLysAlaGluAlaAlaArgLysArgLysGlyLysArgLysGlyValSerHisLysGlyLysLysG lyGlyLysLysGlnAlaGlu-376 Hydrophilic Regions - Hopp-Woods 14-ValGlyGlyLysGluHisArgHisTrpGluArgTyrAspIleAspSer-29 54-LeuSerGlyGluSerCysGluValValIle-63 76-GlnArgHisGlyLysSerLysGlySerArgGluLeuSerLeuSerGlyArgAspLeu-94 115-AspAlaAlaLysLysLeu-120 131-ValLeuLysAlaGluAsnAsnProAla-139 141-GlyLysIleAspIleGluProGlyGlu-149 168-LeuGluProAspGly-172 193-ArgThrAspSerArgCysAsnIleGluArgMetAspIleGluTrpAspThrAspAsnArgPheSer-214 222-SerHisGlyArgSerGlyAspSerAlaLysHisAspLeu-234 246-HisArgProLysThr-250 254-SerAspAlaAspAsn-258 263-GlnLysGlnAlaLysLysGlnLeuAla-271 286-GlyHisLysThrArgAsp-291 303-ValIleAspAspGluHisGlyIle-310 325-ArgMetAspGlyThrGlnThrGluLeuArgLeuLysGluAεpGlyIleTrp-341 345-AlaTyrProLysLysAlaGluAlaAlaArgLysArgLysGlyLysArgLysGlyValSerHisLysGlyLys LysGlyGlyLysLysGlnAlaGlu-376 714 AMPHI Regions - AMPHI 6-IleLeuArgGlyLeuLeuPro-12 34-LeuAspAlaValAlaGluSerAlaGlnSerValAla-45 54-GlyGlnMetLeuAlaAspTrpGluArgValLeuGlyLeu-66 79-AlaValMetAlaLysLeuAsnGluThrGly-88 98-LeuAlaGluAlaAla-102 110-GluProGlnProPhe-114 116-AlaGlyValAsnArgAlaGlyAspArgLeu-125 155-AlaGlyAspArgLeuThrAspTyrSerAspAlaValIleGluSerLeuPheAsnArgLeuLys-175 Antigenic Index - Jameson-Wolf 15-SerTyrAlaArgAsnAlaProArgValArgAlaGlnAlaGluIleAspGlyAlaAla-33 36-AlaValAlaGluSerAlaGlnSerVal-44 46-AspAlaValAspProArgSerAla-53 64-LeuGlyLeuAspGlyThrGlyLysAsnArgGlnHisArg-76 83-LysLeuAsnGluThrGlyGlyLeu-90 107-GlnIleAspGluProGlnProPheArgAlaGlyValAsnArgAlaGlyAspArgLeuAlaPro-127 138-ValArgGlyGlyAsnAsnArgIleThrArgPheArgAlaGlyIle-152 154-AlaAlaGlyAspArgLeuThrAspTyrSerAspAlaValIle-167 170-LeuPheAsnArgLeuLysPro-176 Hydrophilic Regions - Hopp-Woods 18-ArgAsnAlaProArgValArgAlaGlnAlaGluIleAspGlyAlaAla-33 36-AlaValAlaGluSerAlaGlnSerVal-44 46-AspAlaValAspProArgSerAla-53 68-GlyThrGlyLysAsnArgGlnHisArg-76 107-GlnIleAspGluProGlnProPhe-114 117-GlyValAsnArgAlaGlyAspArgLeuAlaPro-127 139-ArgGlyGlyAsnAsnArgIleThrArgPheArgAla-150 154-AlaAlaGlyAspArgLeuThrAspTyrSerAspAlaValIle-167 170-LeuPheAsnArgLeuLysPro-176 715 AMPHI Regions - AMPHI 15-GlnIleGluArgLeuGlyAsnGlyIle-23 3l-ArgArgLeuSerGluThrMetHis-38 64-LeuSerAspSerGlyArgLeuLysAspSerPheSer-75 94-IleHisAsnPheGlyGly-99 Antigenic Index - Jameson-Wolf 15-GlnIleGluArgLeuGlyAsnGlyIleGluAsnArgTyrLeuLeu-29 47-TyrAlaGlyArgProLysTrpValGlyLeuLysTyrArgAspGlyLysProLeuSerAεpSerGlyArgLeuL ysAspSerPheSerThrLeuSerAspAsnAspThrAla-83 98-GlyGlyMetAlaGlyArgAsnArgLysValArgIleProGlnArgGluPhe-114 118-ThrAspAspAspLysGlnAlaLeuMetAspAspValGlnAεp-131 Hydrophilic Regions - Hopp-Woodε 15-GlnIleGluArgLeuGlyAsn-21 57-LysTyrArgAspGlyLysProLeuSerAεpSerGlyArgLeuLysAspSerPhe-74 78-SerAspAsnAspThr-82 lOl-AlaGlyArgAsnArgLysValArgIleProGlnArgGlu-113 118-ThrAspAspAspLysGlnAlaLeuMetAεpAεpValGlnAεp-131 716 AMPHI Regions - AMPHI 33-GlyValHisLysSerAlaHisGly-40 71-AlaThrValLysLysThrHisLysHisThrLysAla-82 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnIle-5 23-AlaAlaAsnLysProAlaSerAεnAlaThrGlyValHiεLysSerAlaHisGlySerCysGlyAlaSerLysS erAlaGluGlySerCysGlyAlaAlaGlySerLysAlaGlyGluGlyLysCysGlyGluGlyLysCysGlyAlaTh rValLysLysThrHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysGlyGluGly LysCysGlySerLys-102 Hydrophilic Regions - Hopp-Woods 23-AlaAlaAsnLysProAlaSer-29 33-GlyValHisLysSerAlaHis-39 43-GlyAlaSerLysSerAlaGluGlySerCys-52 55-AlaGlySerLysAlaGlyGluGlyLysCysGlyGluGlyLysCys-69 71-AlaThrValLysLysThrHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysG lyGluGlyLysCysGlySerLys-102 717 AMPHI Regions - AMPHI 175-AlaValTyrAlaLeuAlaAsn-181 209-LeuHisArgGlyLeu-213 223-SerIleAlaTyrTrp-227 241-AlaGlyLeuGluGlnLeuGly-247 263-GlnSerIlePheSerThrValTrpThrProTyrIlePheArgAlaIleGluGlu-280 305-ThrGlyIlePheSerProLeuAlaSer-313 347-LeuAsnValValArgLysThr-353 358-LeuAlaThrLeuGlyAlaLeuAla-365 401-SerSerCysArgLeuTrpGlnProLeuLysArgLeu-412 430-CysPheGlyThrPro-434 442-GlyValTrpAlaAlaTyrLeuAlaGly-450 457-LysAspLeuHisLysLeuPheHisTyr-465 Antigenic Index - Jameson-Wolf 1-MetAspThrLysGlu-5 32-ProAlaAspAspIleGlyArg-38 66-TyrAlaThrAlaAspLysAspThrLeu-74 95-SerArgProSerLeuProSerGluIle-103 135-MetGluGlyArgAla-139 192-AsnArgCysArgLeuLysAlaVa1Arg-200 231-SerAlaAspArgLeuPheLeu-237 277-AlaIleGluGluAsnAlaProProAlaArgLeu-287 289-AlaThrAlaGluSer-293 317-ProGluAsnTyrAla-321 349-ValValArgLysThrArgProIleAla-357 376-ProSerGlyGlyAlaArgGly-382 397-PheLysThrGluSerSerCysArgLeu-405 453 -LeuArgHisArgLysAspLeuHis-460 Hydrophilic Regions - Hopp-Woods l-MetAspThrLysGlu-5 66-TyrAlaThrAlaAspLysAspThrLeu-74 135-MetGluGlyArgAla-139 192-AsnArgCysArgLeuLysAlaValArg-200 277-AlaIleGluGluAsnAlaProProAlaArgLeu-287 289-AlaThrAlaGluSer-293 349-ValValArgLysThrArgPro-355 378-GlyGlyAlaArgGly-382 398-LysThrGluSerSerCys-403 453-LeuArgHisArgLysAspLeuHis-460 718-1 AMPHI Regions - AMPHI 28-IleThrAlaThrGlyArgValIleAlaGluHisProSerAsnPheIleThrProGln-46 49-ArgAlaLeuPheGlu-53 110-AspGlnAlaTyrGluMetMetAspSerLeuProThr-121 124-AspLeuIleMetAspLeuMetAspAlaValGlyHisGly-136 160-ProGlnSerTrpPheLys-165 198-ArgSerValGlnGln-202 210-ThrLeuSerTrpLeuTyrMetPhe-217 219-HisTyrAlaValHiεAspPheAlaGluPheLeuGluLeu-231 255-ArgAlaValAlaGluIle-260 280-AlaAsnGlyThrThr-284 320-ThrAsnAlaLeuGlyAsnIleHisAsnGluValArg-331 341-GlnValAlaGlnThrIleThrSerGlnIleIleGlyProPhe-354 363-AspProAsnArgVal-367 376-GluProLysAspIleAlaValPheAlaAspAlaIleProLysLeuValAsp-392 395-ValGlnIleProGlu-399 420-ArgGlnValProAspAsnPro-426 448-HisGlnGluIleLeuAspGlyAlaLeuAspAsp-458 469-LeuAsnProMetValArgGlnAlaValAlaAlaLeuAsnAlaCysAsnSerTyrGlu-487 Antigenic Index - Jameson-Wolf 4-IleMetAlaLysLysAsnAsnLysThrLysIleGlnLysProGluAlaAlaLeu-21 30-AlaThrGlyArgValIleAla-36 38-HisProSerAsnPhe-42 44-ThrProGlnLysMetArgAlaLeuPheGluAspAlaGluSerGlyAspIleArgAlaGlnHis-64 68-AlaAspIleGluGluArgAspSerAspIle-77 81-MetGlyThrArgLysArgAla-87 95-ValAlaProProArgAsnAlaThrProGluGluGluLysLeuSerAspGlnAlaTyrGluMet-115 119-LeuProThrLeuGlu-123 148-AspGlyLeuTyrLeuProArgAsnPheIleHisArgProGlnSerTrpPheLysTrpAspLysAspAsnGly Leu-172 174-LeuArgThrArgGluAsnProGluGlyGluAla-184 193-HisThrGlnLysSerArgSerValGlnGlnAlaArgAsnGlyLeuPhe-208 237-ArgIleGlyLysTyrGlyAlaGlyAlaThrLysGluGluLysAsnThrLeu-253 268-MetProGluGlyMetGluIleGluLeu-276 280-AlaAsnGlyThrThrAlaThr-286 295-AspTrpCysGluLysSerAlaAla-302 310-LeuThrSerGlyAlaAspGlyLysSerSerThrAsnAlaLeuGly-324 328-AsnGluValArgArgAspLeuLeuValSerAspAlaLysGlnVal-342 359-TyrProHisAlaAspProAsnArgValProLysPheGluPheAspThrArgGluProLysAspIle-380 397-IleProGluSerTrpValArgAspLysLeuVal-407 410-AspValGlnGluGlyGluAlaValLeu-418 420-ArgGlnValProAspAsnProValAsnArg-429 440-ValProSerLysAlaThrGlyArgHisGlnGluIleLeuAspGlyAlaLeuAsp-457 459-AlaLeuValGluProAspPheAsnSerGlnLeu-469 484-AsnSerTyrGluGluAlaAspAla-491 499-AsnLeuAspAsnAlaLysLeuArgThr-507 519-LeuGlyGlnAspHisAlaArgAla-526 Hydrophilic Regions - Hopp-Woods 4-IleMetAlaLysLysAsnAsnLysThrLysIleGlnLysProGluAlaAlaLeu-21 46-GlnLysMetArgAlaLeuPheGluAεpAlaGluSerGlyAspIleArgAlaGlnHis-64 68-AlaAspIleGluGluArgAεpSerAspIle-77 81-MetGlyThrArgLysArgAla-87 96-AlaProProArgAsnAlaThrProGluGluGluLysLeuSerAspGlnAlaTyrGluMet-115 165-LysTrpAspLysAspAsnGlyLeu-172 174-LeuArgThrArgGluAsnProGluGlyGluAla-184 195-GlnLysSerArgSerValGlnGlnAlaArg-204 245-AlaThrLysGluGluLysAsnThrLeu-253 270-GluGlyMetGluIleGluLeu-276 295-AspTrpCysGluLysSerAlaAla-302 312-SerGlyAlaAspGlyLysSerSerThr-320 328-AsnGluValArgArgAspLeuLeuValSerAspAlaLysGlnVal-342 363-AspProAsnArgValProLysPheGluPheAspThrArgGluProLysAsp-379 401-TrpValArgAspLysLeuVal-407 410-AspValGlnGluGlyGluAlaValLeu-418 421-GlnValProAspAsnProValAsn-428 440-ValProSerLysAlaThrGlyArgHisGlnGluIleLeuAspGlyAlaLeuAsp-457 485-SerTyrGluGluAlaAspAla-491 501-AspAsnAlaLysLeu-505 522-AspHisAlaArgAla-526 719 AMPHI Regions - AMPHI 21-ArgLeuLeuAlaAspThrGlnArgGlnLeuAspArgThrAla-34 68-AlaPheAsnArgLeuAlaArgSerGlyLys-77 79-SerGlnAsnAspLeu-83 104-GlyThrGlyPheAlaAspLysMetGlyLysIleGlyArgPheGlyAla-119 143-AspGluAsnIleAsnArgValSerArg-151 191-AlaLeuAspLeuIleSerGlyMetMet-199 229-ThrAlaLysLeuIleLysThrLeuLysAsp-238 254-LeuGlnSerGlyLeu-258 266-AspMetValArgGluLeuProSerLeuLeuSer-276 280-GlnAlaGlyMetAsnGlyValGlyGlyLeuAspTyrLeuLeuSerLeuLeu-296 308-GluAlaAlaThrAsnValGlnAsnLeuLeuSerLys-319 324-AspThrIleGlyArgLeuLysLysMetAlaAsnProAsnAspProLysLysGlyValAspTrpIleGlySer -347 360-GlnValLeuSerArgLeuAlaAsp-367 404-GlnLeuLeuProAspLeu-409 418-AlaThrAspMetThrGlnIleArgGluTyrMetAlaSerLeu-431 467-GluSerLeuThrGlyThr-472 477-GluThrSerPheLysLysLeuAlaAlaGlu-486 497-LeuThrThrAlaAla-501 519-GlyPheLeuLysAspValGly-525 557-AlaGlySerGlyLeu-561 588-LeuProLysGlyLeuArgGlyThr-595 597-ThrThrProGluMe111eAsnArgLeuLys-606 626-ProGlnTyrLeuAlaAlaPro-632 635-GlnProThrAspLysMetLeuSerProLeuPhe-645 676-ThrGlyLeuAlaGlnValGlnSerAlaMetAla-686 707-AsnGluValSerArg-711 Antigenic Index - Jameson-Wolf l-MetAlaAsnGlyAsnMet-6 14-AlaArgAspAspGlyAlaArgArgLeuLeuAlaAspThrGlnArgGlnLeuAspArgThrAlaLysSerArgA laGlnLeuGluArgGlnSerHisThrTyr-47 51-GlyIleArgSerGluLysGlnIleGlnArg-60 71-ArgLeuAlaArgSerGlyLysAlaSerGlnAsnAspLeuAlaArg-85 90-ThrArgAsnArgIleArgGluLeuAsnAlaGluLeuLysGlnGlyThrGlyPheAlaAspLysMetGlyLysI leGlyArgPheGly-118 134-ProAlaMetAspAsnArgLysGlnLeuAspGluAsnIleAsnArgValSerArg-151 153-AlaPheIleGluAεpAsnSerLysSerAla-162 168-GluGlyAlaGlnGlnIleLysAspLeuAla-177 180-LeuValGluLysAsnGlyGlyThrHisAspLysAlaLeuAsp-193 207-GlnThrLysAsnGluAla-212 222-SerGluGlySerGlyGluAspThrAlaLysLeu-232 234-LysThrLeuLysAspGlyGlyMetSerGlyLysAspLeuGlnLeu-248 256-SerGlyLeuAspGlyThrPheGluValArgAspMetValArgGluLeuProSer-273 299-AlaAlaAsnLysSerGlySerProAlaGluAla-309 318-SerLysThrLeuSerProAspThrIleGlyArgLeuLysLysMetAlaAsnProAsnAspProLysLysGly ValAspTrp-344 349-ValGlnGlyLysGlnAsnGlyGluAsn-357 369-MetLeuValLysAspLysGlnTyrGlnAspTyrLysLysArgAlaAlaAlaGlyAspLysThrAlaAlaGlu Gln-393 422-ThrGlnIleArgGluTyrMet-428 437-AspAsnGlyLysIleAlaLysAsnAsnGluAlaArgMet-449 454-AlaGlnGlnGluGlnGlnGluSer-461 463-AlaMetLeuArgGluSerLeu-469 474-ValAspMetGluThrSerPheLysLysLeuAlaAla-485 511-ThrAlaGlyGlyGlyLysGlyAlaGlyPhe-520 522-LysAspValGlySerLysAla-528 532-GlyLysAlaSerAlaGlyGly-538 545-AlaAlaGlyGlyLys-549 554-GlyLysSerAlaGlySerGlyLeuMetAsnAsnProAlaLeuValLysArgAlaGly-572 580-SerGluSerLeuGlyAspGlyThrLeuProLysGlyLeuArgGlyThrLysThrThrPro-599 601-MetIleAsnArgLeuLysAsnAsnGlyIleArgPheGluProAlaProLysArgGluGlnAlaArgGlyGly ValPro-626 631-AlaProSerAlaGlnProThrAspLysMetLeuSerPro-643 687-SerAlaSerGlnThrIleAsnThrAsnValSerLeuAsnIleAspGlyArgValIleAla-706 708-GluValSerArgTyrGln-713 718-GlyArgGlyAlaGlyGln-723 Hydrophilic Regions - Hopp-Woods 14-AlaArgAspAspGlyAlaArgArgLeuLeuAlaAspThrGlnArgGlnLeuAspArgThrAlaLysSerArgA laGlnLeuGluArgGlnSer-44 52-IleArgSerGluLysGlnIleGlnArg-60 71-ArgLeuAlaArgSerGlyLysAlaSerGlnAsnAspLeuAlaArg-85 90-ThrArgAsnArgIleArgGluLeuAsnAlaGluLeuLysGln-103 107-PheAlaAspLysMetGlyLysIleGlyArg-116 134-ProAlaMetAspAsnArgLysGlnLeuAspGluAsnIleAsnArgValSerArg-151 153-AlaPheIleGluAspAsnSerLys-160 168-GluGlyAlaGlnGlnIleLysAspLeuAla-177 180-LeuValGluLysAsnGlyGlyThrHiεAεpLysAlaLeuAsp-193 207-GlnThrLysAsnGluAla-212 222-SerGluGlySerGlyGluAspThrAlaLysLeu-232 234-LysThrLeuLysAspGlyGlyMetSerGlyLysAspLeuGlnLeu-248 262-PheGluValArgAspMetValArgGluLeuPro-272 299-AlaAlaAsnLysSerGlySerProAlaGluAla-309 325-ThrIleGlyArgLeuLysLysMetAlaAsnProAsnAspProLysLysGlyVal-342 349-ValGlnGlyLysGlnAsnGlyGluAsn-357 369-MetLeuValLysAspLysGlnTyrGlnAspTyrLysLysArgAlaAlaAlaGlyAspLysThrAlaAlaGlu Gln-393 422-ThrGlnIleArgGluTyrMet-428 437-AspAsnGlyLysIleAlaLysAsnAsnGluAlaArgMet-449 454-AlaGlnGlnGluGlnGlnGluSer-461 463-AlaMetLeuArgGluSerLeu-469 474-ValAspMetGluThrSerPheLysLysLeuAlaAla-485 522-LysAspValGlySer-526 567-LeuValLysArgAlaGly-572 590-LyΞGlyLeuArgGlyThrLysThrThrPro-599 601-MetIleAsnArgLeuLysAεnAsnGlyIleArgPheGluProAlaProLysArgGluGlnAlaArgGlyGly -624 635-GlnProThrAspLysMetLeu-641 700-IleAspGlyArgValIleAla-706 720 AMPHI Regions - AMPHI 6-ThrLeuLeuGlnAspAlaSer-12 24-AspGluSerAsnGlyLysAlaLeuAlaGluHisAlaArgProPhe-38 65-TyrAlaGlyArgLeuLysLysLeuLeuAspAlaLeuGluGlnPro-79 87-ProValTrpGlyArgMetHisAsnMetIleAlaAla-98 142-IleAlaAsnIleAspThrTyrArg-149 166-ValSerAlaLeuTrpGlySerAlaLeuGly-175 184-PheGlyAlaValArgArgLeuPheAspLeuAspLysIleAla-197 212-GlySerAlaLysLeuPheAlaAspIleSerVal-222 268-LeuThrGlyArgPheSerAspGlyLeuGlnAsnArgLeuAsnArgLeu-283 293-GlnAlaValArgLeuLeuSerThrSer-301 320-AlaProAspLeuIleGluValAsn-327 340-AlaLeuArgAlaValGlnThrAla-347 365-GlnThrAlaGluSerLeu-370 376-ArgLeuAsnAlaLeuValAla-382 400-GlyThrIleHisGlnIleAlaHisGluPheTyrGlyAspIleAlaArgAlaAlaGluLeuVal-420 Antigenic Index - Jameson-Wolf 8-LeuGlnAspAlaSerTyrLysGlyValGlyPhe-18 21-GluValValAspGluSerAsnGlyLysAlaLeuAlaGluHisAlaArg-36 42-IleAspLeuGluAspMetGlyMetThrGlyArg-52 62-GlyLysGlyTyrAlaGlyArgLeuLysLysLeuLeuAspAlaLeuGluGlnProGlyGlyGly-82 101-SerTyrArgHisGluAlaAspTyr-108 117-ThrPheArgGluAlaAlaGluAlaGln-125 146-AspThrTyrArgGluAlaAla-152 189-ArgLeuPheAspLeuAspLys-195 197-AlaPheProAspArgGlyGlyTyrSer-205 209-PheLysAsnGlyΞer-213 226-ThrGlyIleArgArgGluAlaGlyLeu-234 244-TrpSerProArgGlnArgPheAspGly-252 256-ValAlaAspArgAlaAlaAlaIleProAspAsn-266 270-GlyArgPheSerAspGlyLeuGlnAsnArgLeuAsnArgLeuThrAlaLysGlnVal-288 313-AlaHiεGlyGluGluMetThrAla-320 322-AspLeuIleGluValAsnArgAlaMetArgArgArgMetGlnAla-336 348-AlaAlaGluSerGlyGlyLeuThrAla-356 365-GlnThrAlaGluΞerLeuArgAlaAlaAla-374 386-AsnGlnLysProProLeu-391 395-GlnAlaProIleAspGlyThr-401 413-IleAlaArgAlaAlaGlu-418 431-PheIleLysArgGlyThrLeuValAsnSerTyrAlaLys-443 Hydrophilic Regions - Hopp-Woods 21-GluValValAspGluSerAsnGlyLysAlaLeuAlaGluHisAlaArg-36 42-IleAspLeuGluAspMetGlyMetThr-50 65-TyrAlaGlyArgLeuLyεLysLeuLeuAspAlaLeuGluGlnProGly-80 104-HisGluAlaAspTyr-108 117-ThrPheArgGluAlaAlaGluAlaGln-125 146-AspThrTyrArgGluAlaAla-152 189-ArgLeuPheAspLeuAspLys-195 197-AlaPheProAspArgGlyGly-203 226-ThrGlyIleArgArgGluAlaGlyLeu-234 246-ProArgGlnArgPheAspGly-252 256-ValAlaAspArgAlaAlaAla-262 276-LeuGlnAsnArgLeuAsnArgLeuThrAla-285 313-AlaHisGlyGluGluMetThrAla-320 322-AspLeuIleGluValAsnArgAlaMetArgArgArgMetGlnAla-336 348-AlaAlaGluSerGlyGly-353 368-GluSerLeuArgAlaAlaAla-374 413-IleAlaArgAlaAlaGlu-418 721 AMPHI Regions - AMPHI 87-AlaGlyTrpMetArgTrpLeuGlu-94 120-ArgTyrIleSerAlaVal-125 135-SerLysIlePheHisAlaAlaLeuThrAsnPheProAlaLeuAspGlyMetAspGluValLeuAla-156 170-AsnProMetLysGluLeuLeuGlnGlnLeuPheAspLeuPro-183 210-AspValPheAlaGln-214 236-LysTyrAlaProIleSerValValGlnGluLeuGln-247 282-TrpAlaLysGlyValLeuLysGlnProGlyGly-292 294-AlaPheLeuThrGlyPheIleGlu-301 Antigenic Index - Jameson-Wolf l-MetSerLysAsnAlaGln-6 16-GluValGlnProLysAspGlyArgIle-24 27-LeuProTyrGlyGlu-31 33-ArgAlaValAspGlyArgProThrAspValProAla-44 48-ThrGluGluAsnGlyHisAsp-54 58-LeuAlaAsnSerSerArgAsnGlnLeu-66 74-ThrLeuTyrLysGluLysAsnGlyGlnProAlaPro-85 94-GluPheThrProLysGlyMetPheAla-102 105-GluTrpThrAspLysAlaAla-lll 115-AlaAlaLysGluTyrArg-120 l26-PheSerTyrAspThrLysGlyTyrVal-134 149-AspGlyMetAspGluValLeu-155 161-GlnIleLeuLysProGluThrGluGlnAsnProMetLysGluLeuLeu-176 183-ProAspAlaGlyGluGluGluLeuLysAla-192 198-ValGluAlaLysProLysAspValAlaLeu-207 215-LeuAlaGluLysAspSerArgIle-222 228-GlnThrAlaLysProAspLeuThrLysTyrAla-238 255-AlaLysGlnGluAlaAspLysGlyAsnGlu-264 277-ProAlaGlnLysGluTrpAla-283 286-ValLeuLysGlnProGlyGly-292 311-GlySerGlnThrGlyGlyLysAlaProAspGluArgValAla-324 327-ThrAlaGluGluAlaAlaAla-333 338-GlyMetSerGlyGluGluPheValLysIleLysGluSerGluGlyLys-353 Hydrophilic Regions - Hopp-Woods l-MetSerLysAsnAlaGln-6 17-ValGlnProLysAspGlyArgIle-24 33-ArgAlaValAspGlyArgProThrAsp-41 49-GluGluAsnGlyHis-53 74-ThrLeuTyrLysGluLysAsnGlyGln-82 105-GluTrpThrAspLysAlaAla-lll 115-AlaAlaLysGluTyrArg-120 149-AspGlyMetAspGluValLeu-155 163-LeuLysProGluThrGluGlnAsnProMetLysGluLeuLeu-176 183-ProAspAlaGlyGluGluGluLeuLysAla-192 198-ValGluAlaLysProLysAspValAlaLeu-207 215-LeuAlaGluLysAspSerArgIle-222 229-ThrAlaLysProAspLeuThrLys-236 255-AlaLysGlnGluAlaAspLysGlyAsnGlu-264 277-ProAlaGlnLysGluTrpAla-283 314-ThrGlyGlyLysAlaProAspGluArgValAla-324 327-ThrAlaGluGluAlaAlaAla-333 340-SerGlyGluGluPheValLysIleLysGluSerGluGlyLys-353 723 AMPHI Regions - AMPHI 57-ThrGlnGlnValGluHisValAspPheValAlaValAla-69 87-AsnValAlaAlaLys-91 123-CysAspLeuAlaVal-127 135-ValGlyGluLeuGlnAspPhe-141 208-SerIleThrSerArg-212 245-LysAlaValValSerIle-250 Antigenic Index - Jameson-Wolf 1-MetArgProLysProArgPheArgArgSerVal-11 55-HisSerThrGlnGln-59 76-HisAlaLeuSerArgArgGlnThrVal-84 92-AlaHisGlnAspGlyArgGlnIleLeuLysArgSerSerGluProProGlnIleArgValAspPheGlySerG lyValHisGlnArgGlyLeuCys-123 142-GlnLeuThrGluThrArgAsnHisIleLeuAsnArgArgValCysHis-157 164-CysSerIleGlySer-168 177-SerProThrSerAlaArgPheThrSerArgGlnProProSerAsnSerArgProProArgGlnAsnSerLeu Pro-201 213-LeuSerAlaLysAlaSerAla-219 229-SerAlaSerSerAlaAspSer-235 260-SerAlaCysThrAlaSerAsn-266 269-LeuMetSerSerAsnAspGlyAlaAla-277 294-CysPheArgArgArgArgIleArgIle-302 Hydrophilic Regions - Hopp-Woods 1-MetArgProLysProArgPheArgArgSerVal-ll 77-AlaLeuSerArgArgGlnThrVal-84 92-AlaHisGlnAspGlyArgGlnIleLeuLysArgSerSerGluProProGlnIleArgValAspPhe-113 142-GlnLeuThrGluThrArgAsn-148 150-IleLeuAsnArgArgValCys-156 183-PheThrSerArgGlnProProSerAsnSerArgProProArgGlnAsnSer-199 213-LeuSerAlaLysAlaSerAla-219 271-SerSerAsnAspGlyAlaAla-277 294-CysPheArgArgArgArgIleArgIle-302 724 AMPHI Regions - AMPHI 6-LeuAlaLysLysThr-10 12-GlnThrAlaLysAsnIleGlyGluThrLeuArg-22 40-ArgValGlnLeuSer-44 47-AlaAspGluThrLeuGlnAspLeuGluHisLeuGlnGlu-59 Antigenic Index - Jameson-Wolf 5-LysLeuAlaLysLysThrAlaGlnThrAlaLysAsnIleGlyGluThrLeuArgAlaAlaPheArgGlyLysIl e-29 34-SerSerGluProIleGlnArgValGlnLeuSerGlyLeuAlaAspGluThrLeuGlnAspLeuGluHis-56 60-TyrGlyPheAlaSerHisProProAspGlySerGluAla-72 77-LeuGlyGlyAsnThrSer-82 90-GlnHisGlySerTyrArgIleLysAsnLeuLysProGlyGluThr-104 108-AsnHisGluGlyAlaLysIleValIleLysGlnGlyLysIleIleGluAlaAspCysAspVal-128 130-ArgValAsnCysLysGlnTyrGlu-137 142-ThrAspAlaLysPhe-146 162-GlnIleAsnGlyAsnGly-167 170-AlaValGluGlyGlyAspGlyAlaThrPheSerGlyAspValAsnGlnThrGlyGlySerPheAsnThrAsp GlyAspValValAla-198 205-GlnHisProHisThrAspSerIleGlyGlyLysThrLeuProAlaGluProAla-222 Hydrophilic Regions - Hopp-Woods 5-LysLeuAlaLysLysThrAlaGlnThrAlaLysAsnIleGlyGluThrLeuArgAlaAlaPheArgGly-27 46-LeuAlaAspGluThrLeuGlnAspLeuGluHis-56 66-ProProAspGlySerGlu-71 94-TyrArgIleLysAsnLeuLysProGlyGlu-103 110-GluGlyAlaLysIleValIleLysGlnGlyLysIleIleGluAlaAspCysAspVal-128 132-AsnCysLysGlnTyrGlu-137 142-ThrAspAlaLysPhe-146 190PheAsnThrAspGlyAspVal-196 205-GlnHisProHisThrAspSerIleGly-213 725 AMPHI Regions - AMPHI H-GluAlaAspAspLeuAlaGlyGlnIleHisThrLeuProAlaValTrp-26 41-GlyValCysGlyArgTyrGlnAsp-48 81-AspLeuIleArgAlaValArgArgLeuLeuAsp-91 104-ValProLysAlaValArgAlaIle-lll 144-ProGluArgThrAspAsnProAsp-151 155-HisIlePheThrLysTyrGlnGlyThrLeuSerGluProTrpProAspPheGlu-172 180-AspProGlnSerAla-184 Antigenic Index - Jameson-Wolf 3-ArgThrValLysSerTyrAsnGlyGluAlaAspAspLeuAla-16 29-TyrGlyGlySerLysValGluProAlaSerThrGlyGlyValCysGlyArgTyrGlnAεpThrAla-50 59-ArgAsnLeuArgAsnGluGlnAlaGlnArgGlnGlyGlyIleAspSerArgGluIleGlySerAsnAspLeuI leArgAlaValArgArgLeuLeuAspGlyGlnArgLeuGlyPheAlaAspSerArgGlyLeuValProLysAlaVa lArg-109 134-AsnThrCysGlyLeuGluAsnAspArgTyrProGluArgThrAspAsnProAspAspProAsn-154 160-TyrGlnGlyThrLeuSerGluProTrpProAspPheGluGlyLeuAspGlyLysIleTyrAspProGlnSer AlaAspGluIlePro-188 192-ThrLeuLysAspLysGln-197 Hydrophilic Regions - Hopp-Woods 8-TyrAsnGlyGluAlaAspAspLeuAla-16 32-SerLysValGluProAlaSer-38 45- rgTyrGlnAspThrAla-50 59-ArgAsnLeuArgAsnGluGlnAlaGlnArgGlnGlyGlyIleAspSerArgGluIleGlySer-79 81-AspLeuIleArgAlaValArgArgLeuLeuAspGlyGlnArg-94 96-GlyPheAlaAspSerArgGlyLeuVal-104 137-GlyLeuGluAsnAspArgTyrProGluArgThrAspAsnProAspAspProAsn-154 172-GluGlyLeuAspGlyLysIleTyrAsp-180 182-GlnSerAlaAspGluIlePro-188 192-ThrLeuLysAspLysGln-197 726 AMPHI Regions - AMPHI 12-AspThrLeuGlyGlyIleProGlu-19 55-ProArgProSerAspTyrHisGlu-62 74-AlaAlaAlaAlaArg-78 llO-IleAspSerPheTyr rg-115 122-AlaArgGlnAlaAsp-126 137-IleAlaAlaAlaArg-141 180-IleGluThrAlaProGlyLeuAspAlaLeuGluLysGluIleGlu-194 Antigenic Index - Jameson-Wolf 5-PheLysAsnGlyPheTyrAspAspThrLeuGlyGlyIleProGluGly-20 24-ValArgAlaGluGluTyr-29 37-AlaGlnGlyGlyGlnIleAlaAlaAspSerAspGlyArgProValLeuThrProProArgProSerAspTyrH isGluTrpAspGlyLysLysTrpLysIleSerLys-72 78-ArgPheAlaLysGlnLysThr-84 90-LeuAlaGluLysAlaAspGluLeuLysAsnSer-100 106-ProGlnValGluIleAspSerPheTyrArgGlnGluLysGluAlaLeuAlaArgGlnAlaAspAsnAsnAla ProThr-131 151-LysValIleGluLysSerAlaArg-158 167-IleGlyLysArgGlnGlnLeuGluAspLysLeuAsnThr-179 181-GluThrAlaProGlyLeuAspAlaLeuGluLysGluIleGluGlu-195 Hydrophilic Regions - Hopp-Woods 24-ValArgAlaGluGluTyr-29 42-IleAlaAlaAspSerAspGlyArgPro-50 55-ProArgProSerAspTyrHisGluTrpAspGlyLysLysTrpLysIleSerLys-72 78-ArgPheAlaLysGlnLysThr-84 90-LeuAlaGluLysAlaAspGluLeuLysAsn-99 114-TyrArgGlnGluLysGluAlaLeuAlaArgGlnAlaAspAsnAsnAla-129 151-LysValIleGluLysSerAlaArg-158 167-IleGlyLysArgGlnGlnLeuGluAspLysLeuAsnThr-179 187-AεpAlaLeuGluLysGluIleGluGlu-195 727 AMPHI Regions - AMPHI 6-LeuLeuAlaAsnAsn-10 12-GlnProIleAlaIleIleAla-18 Antigenic Index - Jameson-Wolf 28-HisHisGlnGlyTyrLysSerAlaPheAlaLyεGln-39 41-AlaValIleAεpLysMetGluArgAspLysAlaGln-52 60-AsnTyrAlaArgGluLeuGluLeuAlaArgAlaGluAlaLysLysTyrGluValLysAla-79 86-LeuAlaLyεLysGlnAlaGluValSerArgLeuLysThrGluArgAspLeuCysLys-104 106-ProPheProProAspSerArgAsnProAsnThrGlyPhe-118 122-SerProGlnIleProProAsnPhe-129 Hydrophilic Regions - Hopp-Woods 41-AlaValIleAspLysMetGluArgAspLysAlaGln-52 60-AsnTyrAlaArgGluLeuGluLeuAlaArgAlaGluAlaLysLysTyrGluValLysAla-79 86-LeuAlaLysLysGlnAlaGluValSerArgLeuLysThrGluArgAspLeuCys-103 109-ProAspSerArgAsnProAsnThr-116 728 AMPHI Regions - AMPHI H-SerPhePheAlaLeuValPheAla-18 39-AlaThrGluValProLysAsnPro-46 48-AlaPheValAlaLysLeuAlaArgLeuPheArgAsnAla-60 76-AsnLeuAlaGlyThrValAspAsp-83 198-GluAspValTyrGluHisCysLeuGlyCysTyrGlnMet-210 218-TyrArgAspValAlaAsnAspGlu-225 235-SerAsnArgIleAlaSer-240 249-GlnAsnMetArgGluLeuMetProArg-257 355-GluLysGluValArgArgTyrAlaGluAlaAlaAlaArg-367 Antigenic Index - Jameson-Wolf 29-IleAsnProArgTrp-33 35-LeuSerAspThrAlaThrGluValProLysAsnProAsn-47 57-PheArgAsnAlaAspArgAl -63 69-GluSerIleArgThrGluGluAsnLeuAlaGlyThrValAspAspGlyProLeuGlnSerGluLysAspTyr- 92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyLys-118 125-HisIleGlyGluGlyGly-130 136-LeuSerGlnArgSerProGluAlaPheVal-145 149-TyrLeuTyrArgAsnAspArgProPheSer-158 166-ValHisGlyGluAsnTyrGluThrThrGlyGluTyrArgVal-179 182-GlnProAspGlySerVal-187 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgLysGluSerAsnArgIleAlaSer AspSerArgAsnSerValPheTyrGlnAsnMetArgGluLeuMetProArgGlyMetLysAlaAsnSer-263 267-GlyTyrAspAlaAspGlyLeuProGlnLys-276 280-SerPheAspAsnGlyLysLysArgGlnSerPheGluTyrTyrLeuLysAsnGlyAsn-298 309-LeuLysAlaAspGlyValThr-315 329-LeuAspGlyGlyArgIleValArgGluGluLysGlnGlyAspArgLeuProAspPhe-347 352-GluAsnLeuGluLysGluValArgArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArgArgAspLeu SerHis-377 Hydrophilic Regions - Hopp-Woods 38-ThrAlaThrGluValProLysAsnPro-46 57-PheArgAsnAlaAspArgAla-63 69-GluSerIleArgThrGluGluAsnLeu-77 80-ThrValAspAspGlyProLeuGlnSerGluLysAspTyr-92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyLys-118 136-LeuSerGlnArgSerProGlu-142 151-TyrArgAsnAspArgProPhe-157 169-GluAsnTyrGluThrThrGlyGluTyr-177 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgLysGluSerAsnArgIleAlaSer AspSerArgAsn-244 250-AsnMetArgGluLeuMetProArgGlyMetLys-260 268-TyrAspAlaAspGlyLeuPro-274 282-AspAsnGlyLysLysArgGlnSer-289 309-LeuLysAlaAspGlyValThr-315 331-GlyGlyArgIleValArgGluGluLysGlnGlyAspArgLeuPro-345 352-GluAsnLeuGluLysGluValArgArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArgArgAspLeu SerHis-377 729 AMPHI Regions - AMPHI 21-CysThrMetIleProGlnTyr-27 33-GluValAlaGluThrPheLysAsnAspThr-42 55-HisAspTyrPheAla-59 61-ProArgLeuGlnLysLeuIleAspIle-69 149-GlnGlyTyrPheAla-153 164-SerLeuIleAlaThrValAlaLys-171 242-LeuAlaThrLeuIleAsn-247 268-LysLeuProAlaGlyLeu-273 322-LeuGlyGlyLeuPheLysSerGly-329 371-ValGlnSerAlaPheGlnAspValAlaAsnAla-381 388-LeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArg-400 419-GlyAlaLeuAspLeuLeuAspAla-426 442-LeuThrArgAlaGluAsnLeuAlaAspLeuTyrLysAlaLeuGlyGlyGlyLeuLys-460 Antigenic Index - Jameson-Wolf 25-ProGlnTyrGluGlnProLysValGluVal-34 36-GluThrPheLysAsnAspThrAlaAspSerGly11eArgAlaValAsp-51 53-GlyTrpHisAspTyrPheAlaAspProArgLeuGlnLys-65 70-AlaLeuGluArgAsnThrSerLeuArgThr-79 85-GluIleTyrArgLysGlnTyrMetIleGluArgAsnAsnLeuLeuPro-100 105-AsnAlaAsnAspSerArgGlnGlySerLeuSerGlyGlyAsnValSerSerSerTyrLysVal-125 138-GlyArgValArgSerSerSerGluAlaAla-147 155-ThrAlaAsnArgAspAlaAla-161 173-TyrPheAsnGluArgTyrAlaGluGluAlaMet-183 188-ArgValLeuLysThrArgGluGluThrTyrLysLeuSerGluLeuArgTyr-204 215-ArgGlnGlnGluAlaLeuIleGluSerAlaLysAlaAspTyr-228 232-AlaArgSerArgGluGlnAlaArgAsn-240 248-GlnProIleProGluAspLeuProAla-256 277-ValLeuLeuAspArgProAspIleArgAlaAlaGluHisAlaLeuLysGlnAlaAsnAla-296 315-ValGlyThrGlySerAlaGluLeu-322 325-LeuPheLysSerGlyThr-330 347-GlyThrAsnLysAlaAsnLeuAspValAlaLysLeuArgGlnGln-361 383-AlaAlaArgGluGlnLeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArgAlaSerLysGluAlaLeu Arg-407 411-LeuArgTyrLysHisGlyValSer-418 424-LeuAspAlaGluArgSerSerTyrAla-432 442-LeuThrArgAlaGluAsnLeu-448 455-LeuGlyGlyGlyLeuLysArgAspThrGlnThrAspLys-467 Hydrophilic Regions - Hopp-Woods 28-GluGlnProLysValGluVal-34 36-GluThrPheLysAsnAspThrAlaAspSerGlyIleArgAlaVal-50 61-ProArgLeuGlnLys-65 70-AlaLeuGluArgAsnThrSerLeu-77 91-TyrMetIleGluArgAsnAsn-97 105-AsnAlaAsnAspSerArgGlnGlySer-113 138-GlyArgValArgSerSerSerGluAlaAla-147 156-AlaAsnArgAspAlaAla-161 177-ArgTyrAlaGluGluAlaMet-183 188-ArgValLeuLysThrArgGluGluThrTyrLysLeuSerGluLeuArgTyr-204 215-ArgGlnGlnGluAlaLeuIleGluSerAlaLysAlaAspTyr-228 232-AlaArgSerArgGluGlnAlaArgAsn-240 250-IleProGluAspLeuPro-255 277-ValLeuLeuAspArgProAspIleArgAlaAlaGluHisAlaLeuLysGlnAlaAsn-295 350-LysAlaAsnLeuAspValAlaLysLeuArgGln-360 383-AlaAlaArgGluGlnLeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArgAlaSerLysGluAlaLeu Arg-407 424-LeuAspAlaGluArgSerSerTyrAla-432 442-LeuThrArgAlaGluAsnLeu-448 458-GlyLeuLysArgAspThrGlnThrAspLys-467 730 AMPHI Regions - AMPHI 6-ArgLeuThrAsnLeuLeuAlaAlaCys-14 26-LeuAlaAlaAspLeu-30 67-LysIleAsnValIleGlnAspTyrThrHisGln-77 lll-AsnHisAlaAlaAsp-115 141-HisProAlaAspAlaTyrAspGlyProLysGlyGlyAsnTyrProLysProThr-158 187-GlnArgIleSerAspAsnTyrSerAsnLeuGlySerAsnPheSerAspArgAlaAspGlu-206 214-HisAsnAlaLysLeu-218 220-ArgTrpGlyAsnSerMetGluPheIleAsnGlyValAla-232 234-GlyAlaLeuAsnProPheIleSer-241 262-AlaAlaMetArgAsnIleAla-268 277-AlaValIleGlyGlyLeuGlySerValAlaGlyPheGluLysAsnThrArgGluAlaValAspArgTrpIle GlnGlu-302 305-AsnAlaAlaGluThrValGluAlaValPheAsnValAlaAlaAlaAlaLysValAlaLysLeuAlaLysAla AlaLysPro-331 338-GlyAspPheAlaAspSerTyr-344 387-AsnGlyArgGluIleAspAlaVal-394 405-ThrIleSerAlaIleAspLysProLys-413 Antigenic Index - Jameson-Wolf 2-LysProLeuArgArgLeuThr-8 35-PheIleThrAspAsnAlaGlnArgGlnHisTyrGluProGlyGlyLys-50 55-GlyAspProArgGlySerValSerAspArgThrGlyLysIleAsnVal-70 97-ArgPheSerGlyHisGlyHisGluGluHisAlaProPheAsp-110 112-HisAlaAlaAspSerAlaSerGluGluLysGlyAsnValAspGluGlyPhe-128 134-AsnTrpGluGlyHisGluHisHisProAlaAspAlaTyrAspGlyProLysGlyGlyAsnTyrProLysPro ThrGlyAlaArgAspGluTyrThr-165 167-HisValAsnGlyThrAlaArgSerIleLysLeuAsnProThrAspThrArgSerIleArgGlnArgIleSer AspAsnTyrSerAsn-195 197-GlySerAsnPheSerAspArgAlaAspGluAlaAsnArgLysMetPheGluHisAsnAlaLysLeuAspArg TrpGlyAsnSer-224 257-TyrAlaIleAspLysAlaAlaMet-264 271-ProAlaGluGlyLys-275 287-GlyPheGluLysAsnThrArgGluAlaValAsp-297 299-TrpIleGlnGluAsnProAsnAlaAlaGluThrVal-310 321-LysValAlaLysLeuAlaLysAlaAlaLysProGlyLysAlaAlaValSerGlyAspPheAlaAspSerTyr LysLysLysLeuAlaLeuSerAspSerAlaArgGln-356 359-GlnAsnAlaLysTyrArgGluAlaLeu-367 373-AspLeuIleArgArgLysThrAspGlySerSerLysPheIleAsnGlyArgGluIleAspAlaValThrAsn Asp-397 400-IleGlnAlaLysArgThrIleSerAlaIleAspLysProLysAsnPheLeuAsnGlnLysAsnArgLysGln IleLysAlaThrIle-428 430-AlaAlaAsnGlnGlnGlyLysArgAlaGluPhe-440 452-SerTyrIleGluSerLysGlyGlyIleValLysThrGlyLeuGlyAsp-467 Hydrophilic Regions - Hopp-Woods 2-LysProLeuArgArgLeuThr-8 39-AsnAlaGlnArgGlnHisTyrGluProGlyGly-49 55-GlyAspProArgGlySerValSerAspArgThrGlyLys-67 102-GlyHisGluGluHisAlaPro-108 112-HisAlaAlaAspSerAlaSerGluGluLysGlyAsnValAspGluGly-127 135-TrpGluGlyHisGluHisHisPro-142 144-AspAlaTyrAspGlyProLysGlyGlyAsnTyrProLys-156 158-ThrGlyAlaArgAspGluTyr-164 170-GlyThrAlaArgSerIleLys-176 178-AsnProThrAspThrArgSerIleArgGlnArgIleSerAsp-191 200-PheSerAspArgAlaAspGluAlaAsnArgLysMetPheGluHisAsnAlaLysLeuAspArgTrpGlyAsn -223 257-TyrAlaIleAspLysAlaAlaMet-264 271-ProAlaGluGlyLys-275 287-GlyPheGluLysAsnThrArgGluAlaValAsp-297 303-AsnProAsnAlaAlaGluThrVal-310 321-LysValAlaLysLeuAlaLysAlaAlaLysProGlyLysAlaAlaVal-336 339-AspPheAlaAspSerTyrLysLysLysLeuAlaLeu-350 361-AlaLysTyrArgGluAlaLeu-367 373-AspLeuIleArgArgLysThrAspGlySerSer-383 386-IleAsnGlyArgGluIleAspAlaValThr-395 400-IleGlnAlaLysArgThrIleSerAlaIleAspLysProLysAsn-414 418-GlnLysAsnArgLysGlnIleLysAlaThrIle-428 430-AlaAlaAsnGlnGlnGlyLysArgAlaGluPhe-440 452-SerTyrIleGluSerLysGlyGlyIle-460 731 AMPHI Regions - AMPHI 17-AlaCysAlaValPro-21 Antigenic Index - Jameson-Wolf 22-GluAlaTyrAspAspGlyGlyArgGlyHis-31 34-ProValGlnAsnGlnAlaGlyThrAspAspPheArg-45 48-SerCysGluAsnGlyLeu-53 55-ValArgValArgHisLeuAspSerGlyLysValAlaLeuArgLeuAspGlyArgArgAlaValLeuSerSerA spValAlaAlaSerGlyGluArgTyrThrAla-89 98-ThrGluTrpHisGlnLysGlyGlyGluAla-107 113-AspAlaTyrGlyAsnSerValGluThrSerCysArgAlaArg-126 Hydrophilic Regions - Hopp-Woods 22-GluAlaTyrAspAspGlyGlyArgGlyHis-31 39-AlaGlyThrAspAspPheArg-45 55-ValArgValArgHisLeuAspSerGlyLysValAlaLeuArgLeuAspGlyArgArgAlaValLeu-76 80-ValAlaAlaSerGlyGluArgTyrThrAla-89 100-TrpHisGlnLysGlyGlyGlu-106 119-ValGluThrSerCysArgAlaArg-126 732 AMPHI Regions - AMPHI 14-LeuGlyAlaIleSer-18 43-ValGlnSerIleArgThrMetAlaGluValTyrGly-54 66-AspAlaAspLeuPheGluGlyAlaMetLysGlyMetVal-78 95-GluIleLysGluSerThrSerGly-102 115-AspGlyPheValLysValValSerProIleGluAsp-126 155-GluAlaValLysLysMet-160 183-ValAsnLeuThrArg-187 214-GluArgThrValGluSerValAεnThrAlaAlaLys-225 283-LysAlaIleProGluAsp-288 297-SerLeuAlaGlyIleProAlaGluLeu-305 322-SerGluIleValAlaGly-327 400-LeuValGlyHisIleGlyAsn-406 446-ArgArgIleProAsnProAlaLysAsp-454 459-LysAlaLeuAspLeuValLysSerProGluGlnTrpGlnLysSerLeu-474 Antigenic Index - Jameson-Wolf 30-AlaAlaGluLysAspArgArgAspAsnGluVal-40 59-AsnTyrTyrGlnAspLysProAspAlaAspLeuPhe-70 82-AspProHisSerGluTyrMetAspLysLysGlyTyrAlaGluIleLysGluSerThrSerGlyGluPheGlyG ly-106 lll-IleGlyGlnGluAspGlyPhe-117 122-SerProIleGluAspThrProAlaGluArgAlaGlyValLysSerGlyAspPhe-139 144-AspAsnValSerThrArgGlyMetThr-152 155-GluAlaValLysLysMetArgGlyLysProGlyThrLysIle-168 172-LeuSerArgLysAsnAlaAspLysProIle-181 199-LeuIleGluProAspTyrGlyTyr-206 211-GlnPheGlnGluArgThrValGlu-218 221-AsnThrAlaAlaLysGluLeuValLysGluAsnLysGlyLysProLeuLys-237 2 2-AspLeuArgAspAspProGlyGlyLeu-250 269-ValSerThrLysGlyArgAspGlyLysAspArgMetVal-281 284-AlaIleProGluAspTyr-289 292-GlyMetGlyGlyAspSer-297 303 -AlaGluLeuLysThr-307 316-SerGlySerAlaSerAla-321 330-GlnAspHisLysArgAlaVal-336 340-ThrGlnSerPheGlyLysGlySerVal-348 354-LeuSerAsnGlySer-358 368-TyrThrProAsnAspArgSerIleGln-376 384-ValGluValLysAspLysGluArgIlePheGluSerArgGluAlaAspLeu-400 405-GlyAsnProLeuGlyGlyGluAspValAsnGly-415 421-ProLeuGluLysAspAlaAspLysProAlaValLysGluLysGlyLysLysLysLysAspGluAspLeuSer SerArgArglleProAsnProAlaLysAspAspGlnLeuArgLysAlaLeuAspLeuValLysSerProGluGlnT rpGlnLys-472 477-AlaAlaLysLysProValSerAsnLysAspLysLysAspLysLysAspLysLys-494 Hydrophilic Regions - Hopp-Woods 30-AlaAlaGluLysAspArgArgAspAsnGluVal-40 60-TyrTyrGlnAspLysProAspAlaAspLeuPhe-70 82-AspProHisSerGluTyrMetAspLysLysGlyTyrAlaGluIleLysGluSerThrSerGlyGlu-103 Hl-IleGlyGlnGluAspGlyPhe-117 122-SerProIleGluAspThrProAlaGluArgAlaGlyValLysSerGlyAspPhe-139 144-AspAsnValSerThr-148 155-GluAlaValLysLysMetArgGlyLysProGlyThr-166 172-LeuSerArgLysAεnAlaAspLysProIle-181 211-GlnPheGlnGluArgThrValGlu-218 221-AsnThrAlaAlaLysGluLeuValLysGluAsnLysGlyLysProLeuLys-237 242-AspLeuArgAspAspProGly-248 271-ThrLysGlyArgAspGlyLysAspArgMetVal-281 303 -AlaGluLeuLysThr-307 330-GlnAspHisLysArgAlaVal-336 370-ProAsnAspArgSerIleGln-376 384-ValGluValLysAspLysGluArgIlePheGluSerArgGluAlaAspLeu-400 408-LeuGlyGlyGluAspValAsnGly-415 421-ProLeuGluLysAspAlaAspLysProAlaValLysGluLysGlyLysLysLysLysAspGluAspLeuSer SerArgArglleProAsnProAlaLysAspAspGlnLeuArgLysAlaLeuAspLeuValLysSerProGluGlnT rpGln-471 477-AlaAlaLysLysProValSerAsnLysAspLysLysAspLysLysAspLysLys-494 733 AMPHI Regions - AMPHI 6-ThrLeuSerArgLeuSer-ll 33-TyrGlyGlyTyrProAspThrValTyrGluGly-43 53-LysGlnThrGluLysMetGluLysTyrPheVal-63 92-GlyAlaPheArgGlnPheGluGlu-99 Antigenic Index - Jameson-Wolf 2-MetAsnProLysThrLeuSer-8 22-CyεGlyGlyAsnGlyGlnLysSer-29 33-TyrGlyGlyTyrProAspThrValTyrGluGlyLeuLysAsnAspAspThrSerLeuGlyLysGlnThrGluL ysMetGluLysTyrPhe-62 65-AlaGlyAsnLysLysMetAsnAlaAlaProGlyAla-76 84-LeuSerArgSerGlyAspLysGluGlyAlaPheArgGlnPheGluGluGluLysArgLeuPheProGlu-106 115-MetLysThrGlyLysGlyGlyLysArg-123 Hydrophilic Regions - Hopp-Woods 40-ValTyrGluGlyLeuLysAεnAspAspThrSerLeuGlyLysGlnThrGluLysMetGluLysTyrPhe-62 65-AlaGlyAsnLysLysMetAsnAla-72 86-ArgSerGlyAspLysGluGlyAlaPheArgGlnPheGluGluGluLysArgLeuPhePro-105 115-MetLysThrGlyLysGlyGlyLysArg-123 734-2 AMPHI Regions - AMPHI 19-ArgAlaAlaAspThrTyr-24 26-TyrLeuAlaValTrpGlnAsnProGlnAsnAlaAsp-37 53-GluAlaPheSerGluLeuGluAlaPheCysLys-63 77-ThrGlyCysArgSerValValSer-84 92-LeuAlaTyrProLysAlaLeuGlyAlaLeuArg-102 113-ArgPheThrSerVal-117 12l-AlaLeuAsnGlnCysIleLys-127 Antigenic Index - Jameson-Wolf 18-AlaArgAlaAlaAsp-22 31-GlnAsnProGlnAsnAlaAspAspValLeuGln-41 43-LysThrThrLysGluAspSerThrLysSerGluAlaPheSerGlu-57 59-GluAlaPheCysLysGlyGlnAspThr-67 71-IleAlaGluAspGluProThrGlyCysArgSer-81 101-LeuArgValAspAsn-105 lll-SerProArgPheThrSer-116 125-CysIleLysLysTyrGlyVal-131 145-SerSerTyrTyrGly-149 Hydrophilic Regions - Hopp-Woods 18-AlaArgAlaAlaAεp-22 34-GlnAsnAlaAspAspValLeuGln-41 43-LysThrThrLysGluAspSerThrLysSerGluAlaPheSerGlu-57 59-GluAlaPheCysLysGlyGlnAspThr-67 71-IleAlaGluAspGluProThrGlyCys-79 101-LeuArgValAspAsn-105 735 AMPHI Regions - AMPHI 6-LeuLeuAlaAsnAsn-10 12-GlnProIleAlaIleIleAla-18 118-GlyCysIleAspGlyPheGly-124 Antigenic Index - Jameson-Wolf 28-HisHisGlnGlyTyrLysSerAlaPheAlaLysGln-39 41-AlaValIleAspLysMetGluArgAspLysAlaGln-52 60-AsnTyrAlaArgGluLeuGluLeuAlaArgAlaGluAlaLysLysTyrGluValLysAla-79 86-LeuAlaLysLysGlnAlaGluValSerArgLeuLysThrGluAsnLysLysGluIleGluAsn-106 108-LeuThrGlnAspArgLysAsnAlaSerGlyGlyCysIleAspGlyPheGlySerHiεGly-127 134-AlaLeuGlyTyrGlyAsn-139 Hydrophilic Regions - Hopp-Woods 41-AlaValIleAspLysMetGluArgAspLysAlaGln-52 60-AsnTyrAlaArgGluLeuGluLeuAlaArgAlaGluAlaLysLysTyrGluValLysAla-79 86-LeuAlaLysLysGlnAlaGluValSerArgLeuLysThrGluAsnLysLysGluIleGluAsn-106 108-LeuThrGlnAspArgLysAsnAlaSer-116 736 AMPHI Regions - AMPHI 13-GlyLeuIleGlnSerLeuGlySer-20 50-GlyValLeuSerVal-54 61-GlyLeuPheValGly-65 70-LeuGlnGlyTyrThrGlnLeuSerLysPheLysSerAlaAspIle-84 93-LeuLeuArgGluLeuGlyProVal-100 120-LeuMetLysThrThrGluGlnLeuGluAlaMetAsnValMet-133 135-ValAsnProValAlaArgValVal-142 144-ProArgPheTrpAlaGlyValPheSerMetPro-154 156-LeuAlaSerIlePheAsnValAlaGlyIlePheGlyAla-168 196-AspValIleAsnGlyLeu-201 230-LeuArgAlaSerThrArgThr-236 Antigenic Index - Jameson-Wolf 37-ValArgProArgLeuSerVal-43 77-SerLysPheLysSer-81 93-LeuLeuArgGluLeuGly-98 109-SerAlaGlyGlyAlaMetThrSer-116 122-LysThrThrGluGlnLeuGlu-128 186-GlnMetGlnAsnAsn-190 224-ProThrSerGluGlyIleLeuArgAlaSerThr-234 Hydrophilic Regions - Hopp-Woods 39-ProArgLeuSerVal-43 77-SerLysPheLysSer-81 93 -LeuLeuArgGluLeuGly-98 122-LysThrThrGluGlnLeuGlu-128 737 AMPHI Regions - AMPHI 56-AlaAlaLeuAlaArgValGlyGly-63 Antigenic Index - Jameson-Wolf 24-AlaHisHisAspGlyHisGlyAspAspAspHisGlyHis-36 38-AlaHisGlnHisAsnLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAlaLeu-58 60-ArgValGlyGlyLysIleThrAspIleAspLeuGluHisAspAsnGlyArgProHisTyrAspValGluIleV alLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArgValIleSerSerArgArgAspAsp-108 Hydrophilic Regions - Hopp-Woods 27-AspGlyHisGlyAspAspAspHisGlyHis-36 40-GlnHisAsnLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAlaLeu-58 61-ValGlyGlyLysIleThrAspIleAspLeuGluHisAspAsnGlyArgProHisTyr-79 82-GluIleValLysAεnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArg-100 102-1leSerSerArgArgAspAsp-108 738 AMPHI Regions - AMPHI 91-LeuMetAsnLeuIleTyrProGlyMetAsnAsp-101 139-IleGlySerLeuLeuGlnSerCysIle-147 228-ThrTyrIleAlaAlaIleAlaLeuIle-236 271-ThrIleLeuGluThrPheThrGlyIle-279 285-ValGluArgValAlaAsnGlyGlyPheThrAspLeuProArgGlnIleGluTrpAsn-303 305-AlaLeuAlaAlaPheGlnSer-311 316-GlyHisGlyTrpAsnSerPheAla-323 338-AspAsnLeuLeuSerAsnLeuPheThr-346 371-LeuLeuThrGlyIleAlaGlyLeuLeuLysArg-381 398-MetCysHisSerMetLeu-403 461-ArgLeuValAsnAlaPheSerPro-468 472-AspSerAlaLysThrLeuAsnArgLys-480 482-AsnGluLeuArgTyrIleSer-488 507-LeuProGluTyrProGluThr-513 549-AlaLysGlnTrpMetArgAlaThr-556 567-TyrAlaAspGluIleArgLysLeuProVal-576 579-ProLeuLeuProGluLeuLeuLysAspCysLysAlaPheAlaAlaAlaPro-595 Antigenic Index - Jameson-Wolf 37-LysLeuLysProSerProAspPheTyr-45 62-AlaGlyLysLysLeuPheAsp-68 124-PheGlyGlnGluArgIle-129 154-GlyTrpGluAspThrProLeu-160 177-GlyGlnArgAsnAsnLeuGly-183 196-LeuAsnGlyGlnArgLysIlePro-203 242-PheArgSerAspLysSerAsnArgArgThrMet-252 283-ThrAlaValGluArgValAlaAsnGlyGlyPheThrAspLeuProArgGlnIleGluTrp-302 316-GlyHisGlyTrpAsnSerPheAla-323 378-LeuLeuLysArgProLeuThr-384 424-ProAlaGluAlaSerAspGlyIleAlaPheLysLysAlaAla-437 468-ProAlaThrAspAspSerAlaLysThrLeuAsnArgLys11eAsnGlu-483 508-ProGluTyrProGluThrGlnThrTrpAlaGlu-518 520-AlaThrLeuLysSerLeuLysTyrArgProHisSerAla-532 542-ArgGlnGlyLysValAlaGluAlaLysGlnTrpMet-553 555-AlaThrGlnSerTyr-559 566-ArgTyrAlaAspGlulleArgLys-573 584-LeuLeuLysAspCysLysAla-590 595-ProGlyHiεProGluAlaLysProCysLys-604 Hydrophilic Regions - Hopp-Woods 38-LeuLysProSerPro-42 62-AlaGlyLysLysLeuPheAsp-68 125-GlyGlnGluArgIle-129 198-GlyGlnArgLysIlePro-203 243-ArgSerAspLysSerAsnArgArgThrMet-252 283-ThrAlaValGluArgValAla-289 378-LeuLeuLysArgProLeuThr-384 425-AlaGluAlaSerAsp-429 431-IleAlaPheLysLysAlaAla-437 469-AlaThrAspAspSerAlaLysThrLeuAsnArgLysIleAsnGlu-483 525-LeuLysTyrArgPro-529 542-ArgGlnGlyLysValAlaGluAlaLysGlnTrpMet-553 566-ArgTyrAlaAspGluIleArgLys-573 584-LeuLeuLysAspCysLysAla-590 596-GlyHisProGluAlaLysProCysLys-604 739-2 AMPHI Regions - AMPHI 6-AsnLysProPheArgLeu-11 53-HisThrAspSerPro-57 88-GlnProAspGlyThrAsp-93 120-ThrAspArgGlnProAspAspAlaGlyThr-129 131-AlaGluAsnThrLeu-135 Antigenic Index - Jameson-Wolf l-MetAlaLysLysProAsnLysProPheArgLeuThrPro-13 39-PheAsnProAsnGlyAspLysThrLeuGlnAlaGluProGlnHisThrAspSerProArgGluThrGluPhe- 62 64-LeuProAsnGlyValValGlyGlnAspAlaAlaGlnProGluHisHisHis-80 82-AlaSerSerGluProAlaGlnProAspGlyThrAspGluSerGlySerGlyLeuProSerProAlaAlaProL ysLysAsnArgValLysProGlnProAlaAspThrAlaGlnThrAspArgGlnProAspAspAlaGlyThrGlnAl aGluAsnThrLeuLysGluThrProValLeuProThrAsnValProArgProGluProArgLysGluThrProGlu LysGlnAlaGlnProLysGluThrProLysGluAsnHisThrLysProAspThrProLysAsnThrProProLysP roHisLysGluIleLeu-187 Hydrophilic Regions - Hopp-Woods 1-MetAlaLysLysProAsnLysProPheArgLeu-ll 41-ProAsnGlyAspLysThrLeuGlnAlaGluProGlnHisThrAspSerProArgGluThrGlu-61 72-AspAlaAlaGlnProGluHisHisHis-80 82-AlaSerSerGluProAlaGlnProAspGlyThrAspGluSerGlySer-97 103-AlaAlaProLysLysAsnArgValLysProGlnProAlaAspThrAlaGlnThrAspArgGlnProAspAsp AlaGlyThrGlnAlaGluAsnThrLeuLysGluThrPro-139 145-ValProArgProGluProArgLysGluThrProGluLysGlnAlaGlnProLysGluThrProLysGluAsn HisThrLysProAspThrProLysAsnThrProProLysProHisLysGluIleLeu-187 740 AMPHI Regions - AMPHI 6-LeuValArgTrpLeuAlaVal-12 28-ProGluAspLysLeuGlnHisLeuIleAsnGlyIle-39 Antigenic Index - Jameson-Wolf 26-AsnProProGluAspLysLeuGln-33 57-IleLysHisHisLeuLysGlnGluPheAspLeuLysArgGlnThr-71 Hydrophilic Regions - Hopp-Woods 27-ProProGluAspLysLeuGln-33 57-IleLysHisHisLeuLysGlnGluPheAspLeuLysArgGlnThr-71 741 AMPHI Regions - AMPHI 32-GlyAlaGlyLeuAlaAspAlaLeuThrAla-41 93-SerArgPheAspPheIleArgGlnIleGlu-102 158-ThrSerPheAspLysLeuProGluGlyGlyArg-168 256-SerAlaGluValLysThrValAsnGlyIleArgHisIleGlyLeuAlaAlaLys-273 Antigenic Index - Jameson-Wolf 21-SerSerGlyGlyGly-25 43-LeuAspHisLysAspLysGlyLeu-50 56-AspGlnSerValArgLysAsnGluLysLeuLysLeu-67 71-GlyAlaGluLysThrTyrGlyAsnGlyAspSerLeuAsnThrGlyLysLeuLysAsnAspLysValSerArgP heAspPhe-97 lOl-IleGluValAspGlyGlnLeu-107 117-ValTyrLyεGlnSerHisSerAla-124 129-GlnThrGluGlnIleGlnAspSerGluHisSerGlyLysMetValAlaLysArgGlnPheArgIleGlyAsp IleAlaGlyGluHisThrSerPheAspLysLeuProGluGlyGlyArgAlaThrTyrArg-172 174-ThrAlaPheGlySerAspAspAlaGlyGly-183 191-PheAlaAlaLysGlnGlyAsnGlyLysIleGluHisLeuLysSerProGluLeuAsnVal-210 213-AlaAlaAlaAspIleLysProAspGlyLysArgHisAla-225 234-AsnGlnAlaGluLysGlySerTyrSer-242 247-GlyGlyLysAlaGlnGluValAlaGly-255 257-AlaGluValLysThrValAsnGly-264 Hydrophilic Regions - Hopp-Woods 43-LeuAspHisLysAspLysGlyLeu-50 57-GlnSerValArgLysAsnGluLysLeuLysLeu-67 71-GlyAlaGluLysThrTyrGlyAsn-78 85-GlyLysLeuLysAsnAspLysValSerArg-94 lOl-IleGluValAspGly-105 132-GlnIleGlnAspSerGluHisSerGly-140 142-MetValAlaLysArgGlnPheArgIle-150 152-AspIleAlaGlyGlu-156 158-ThrSerPheAspLysLeuProGluGlyGlyArgAlaThrTyr-171 177-GlySerAspAspAlaGlyGly-183 195-GlnGlyAsnGlyLysIleGluHisLeuLysSerProGluLeuAsnVal-210 213-AlaAlaAlaAspIleLysProAspGlyLysArgHisAla-225 235-GlnAlaGluLysGlySer-240 249-LysAlaGlnGluValAlaGly-255 257-AlaGluValLysThr-261 742 AMPHI Regions - AMPHI 26-ArgGluValProAsp-30 53 -AsnArgProLeuGln-57 66-GluAspTrpSerArgLeu-71 77-AsnLeuPheSerGlyPheLysHisValPheAsp-87 143-LysAlaLeuGluLysLeuLysAla-150 153-AspGluThrAlaLysGluTyrArg-160 234-AsnAlaAlaGlnArgPheProAεnSerLeuTyrAsp-245 326-ValTyrAlaGlySerCysGlnGlu-333 340-SerSerProLeuVal-344 369-ArgAsnAlaLysLysIle-374 422-ThrProAlaPheThrGlyPheSerGlyThrValProValTrpLysThrValLys-439 448-LeuTyrAsnTyrAlaLysTyrLeuAsnThrAsn-458 475-LeuHisLeuLeuGlyGlyLeuHisTyr-483 505-PheGlnThrAlaSerSer-510 543-IleTyrGlySerTyrThrLysIlePheLysGlnGlnAspAsn-556 616-GlySerPheGlnThrValAlaLysProIleGlyLysValValSerArg-631 643-GluAspTrpLysValPheAlaGly-650 657-ArgTyrLysAsnAla-661 670-AlaLysAsnSerSer-674 677-ProTyrAεnPheSerAsnPheThrProValHisIle-688 714-ThrSerSerLeuTyrAsnIle-720 725-TyrGlyLeuIleAspGlyPheValArgTyr-734 736-LeuGlyLysHisAlaLysLeu-742 759-TyrAsnArgThrArgGlyAlaAsnAsnPheTyrGlyGluPro-772 Antigenic Index - Jameson-Wolf 6-AlaGluAlaAspAlaGlyAsp-12 21-MetTyrGlnLysSerArgGluValProAspPheSerGly-33 37-ProCysGluAsnGlnLysThrAlaProPheSerSerThrProAlaCysAsnArgProLeuGlnLeuProArgA snThrTyrLeuGlyGluAspTrpSerArgLeuSerAlaAspLysTyrAsn-77 86-PheAspAsnGlyTrp-90 97-SerTyrThrLysAsnGluSerAspAlaLysVal-107 120-LeuSerGlyGluAspAla-125 130-ThrGluLysAsnGluValIleProPheGluProLysAspLysAlaLeuGluLysLeuLysAlaTyrArgAsp GluThrAlaLysGluTyrArgGluArgLysAspAspPheValLysAsnArgPheAspAsnThrAla-175 177-GluGlnTyrArgSerArgArgAlaAlaGluArgLysAlaGlyPheAspLysCysMetSerAspProPheAla -200 205-CysGlnGlySerTrpGlyAspProGlyValAεpAlaAspLysAlaGluPheValAsp-223 235-AlaAlaGlnArgPheProAsnSerLeuTyrAspSerSerPheAsnArgLysAlaThrAlaAsnArgArgTyr SerTyrMetPro-262 264-ArgHisThrLysAspAspArgGlnTrp-272 286-GlyArgGluHisAsp-290 295-TyrAlaTyrGlyAspGluLysIleArgSerGluTyr-306 308-GluIleTyrGluArgArgTyrArgValArgProAsnThrGlyAla-322 328-AlaGlySerCysGlnGluGluProAspGlyAspLeuSer-340 345-ArgGlyHisLysGluProAspTrpGlnAlaTyrAspGluLysGlyAsnArgThrValTyrAlaGluGluCys ArgAsnAlaLysLysIleLysThrGluProLysLeuAspAlaGluGlyLysGln-386 389-TyrTyrAspGluTyrSerGlySerArgThr-398 405-TyrGluLeuAspGluLysGlyAsnLysIleGlnGluThrAsnProAspGlyThrPro-423 439-LysValAlaAspAspHisVal-445 454-TyrLeuAsnThrAsnLysThrHis-461 485-ArgTyrGluThrSerGlnThrLysAspMetProValArgTyrGlyGlnProAlaSerAspPheGlnThr-50 7 509-SerSerIleArgAlaAspGlnAspHisTyrThr-519 521-LysMetGlnGlyHisLysLeuThrPro-529 545-GlySerTyrThrLys-549 551-PheLysGlnGlnAspAsnValAspValSerAla-561 584-GlyArgLeuAsnAla-588 595-LeuGluGlnLysAsnArgThrValVal-603 610-GlyAlaGlyGlyLysGlnGlySer-617 628-ValValSerArgGlyAlaGluPheGluLeuSerGlyGluLeuAsnGluAspTrpLys-646 652-ThrTyrAsnLysSerArgTyrLysAsnAlaAlaGluValAsnAlaGluArgLeuAlaLysAsnSerSerAla AspProTyrAsnPheSerAsn-682 708-ValSerAlaGlnSerGlyThrSerSerLeuTyrAsnl1eArgGlnGlyGly-724 735-GluLeuGlyLysHisAlaLys-741 746-GlyThrAsnLeuAsnGlyArgThrTyrPheGluAsnAsnTyrAsnArgThrArgGlyAlaAsnAsnPheTyr GlyGluProArgThrValSerMet-777 Hydrophilic Regions - Hopp-Woods 6-AlaGluAlaAspAlaGlyAsp-12 23-GlnLysSerArgGluValProAsp-30 67-AspTrpSerArgLeuSerAlaAspLys-75 97-SerTyrThrLysAsnGluSerAεpAlaLysVal-107 120-LeuSerGlyGluAspAla-125 130-ThrGluLysAsnGluValIleProPheGluProLysAspLysAlaLeuGluLysLeuLysAlaTyrArgAsp GluThrAlaLysGluTyrArgGluArgLysAspAspPheValLysAsnArgPheAspAsnThrAla-175 177-GluGlnTyrArgSerArgArgAlaAlaGluArgLysAlaGlyPheAspLysCysMetSer-196 212-ProGlyValAspAlaAspLysAlaGluPheValAsp-223 247-SerPheAsnArgLysAlaThrAlaAsnArgArgTyrSer-259 264-ArgHisThrLysAspAspArgGlnTrp-272 286-GlyArgGluHisAsp-290 297-TyrGlyAspGluLysIleArgSerGluTyr-306 308-GluIleTyrGluArgArgTyrArgValArgProAsnThr-320 331-CysGlnGluGluProAspGlyAspLeu-339 345-ArgGlyHisLysGluProAsp-351 354-AlaTyrAspGluLysGlyAsnArg-361 363-ValTyrAlaGluGluCysArgAsnAlaLysLysIleLysThrGluProLysLeuAspAlaGluGlyLysGln -386 393-TyrSerGlySerArg-397 405-TyrGluLeuAspGluLysGlyAsnLysI1eGlnGluThrAsnProAspGly-421 439-LysValAlaAspAspHisVal-445 485-ArgTyrGluThrSerGlnThrLysAspMetProVal-496 500-GlnProAlaSerAsp-504 509-SerSerIleArgAlaAspGlnAspHisTyrThr-519 551-PheLysGlnGlnAspAsnValAspValSerAla-561 597-GlnLyεAsnArgThrValVal-603 611-AlaGlyGlyLysGlnGlySer-617 628-ValValSerArgGlyAlaGluPheGluLeuSerGlyGluLeuAsnGluAspTrpLys-646 654-AsnLysSerArgTyrLysAsnAlaAlaGluValAsnAlaGluArgLeuAlaLysAsnSerSerAlaAsp-67 6 735-GluLeuGlyLysHisAlaLys-741 758-AsnTyrAsnArgThrArgGly-764 770-GlyGluProArgThrValSerMet-777 743 AMPHI Regions - AMPHI 19-TyrGlyGlySerPhe-23 58-SerTyrThrIleAsp-62 64-MetSerThrAlaThrGly-69 96-ThrLeuGluGluAlaMetLysAsnThrThrGlyValAsnValValArgAsp-112 158-ValTyrAspHisIleGluValValArgGlyAlaThrGly-170 Antigenic Index - Jameson-Wolf l-MetAsnGlnAsnHis-5 30-ValSerAspGlyAsnThrVal-36 41-ValAsnValArgGlySer-46 51-GlyLysThrGluLysThrArgSerTyrThrIleAspArgMetSerThr-66 72-IleAlaGlyLysAspThrProGlnSer-80 85-ThrArgSerArgLeuAspAspLysAlaValHisThrLeuGluGluAlaMetLysAsnThrThrGly-106 109-ValValArgAspSerGlyLeuGlnThrArgPheLeuSerArgGlyPhe-124 128-GlnIleGlyGluAspGlyMet-134 140-GlyArgSerGlyTyrThrAlaLysIleAspValSerProSerThrAsp-155 163-GluValValArgGlyAlaThrGlyLeuThrGlnSerAεnSerGluProGlyGly-180 Hydrophilic Regions - Hopp-Woods 51-GlyLysThrGluLysThrArgSerTyrThrIleAspArgMetSerThr-66 72-IleAlaGlyLysAspThrProGln-79 85-ThrArgSerArgLeuAspAspLysAlaValHisThrLeuGluGluAlaMetLysAsn-103 109-ValValArgAspSerGlyLeu-115 128-GlnIleGlyGluAspGlyMet-134 174-SerAsnSerGluProGlyGly-180 744 AMPHI Regions - AMPHI 36-LeuAspGluLeuCys-40 65-AsnPheTyrLysAsnIleHisAlaThrThrLysPheValArgGluThrAspTyrSerLysPheIleGlnLeuL ysLysAlaArgHisLeuThrValSerAspPheThrSerIleTrpLysValIleLeuTyr-108 124-SerSerIlePheAsnLysPheLysAlaLeuAspGluAlaIleAsnGluTyrTyrTyr-142 165-MetIlePheGlyLysPheValLysLeuGly-174 197-ArgLysPheLysAspAla-202 228-PheAspGluTyrHisGluCysValLysGlyLeuAlaAsn-240 270-IlePheAspSerLeu-274 299-TyrArgSerSerLysIlePheGlyValPheAspHisLeuLeuArgThr-314 322-LeuGluLysGlyAsnSer-327 338-AsnLeuHiεAspGluTyrLysAsnLeuThrSerPheIleSerPhe-352 361-ArgAspIleLeuGlnMetLeu-367 416-TyrGlnAsnPheLeuLysPhePheGluPhe-425 434-TyrSerAspPheLeuLysAlaPheGluArgLeuLysLysHis-447 454-GluIleProLysPheMetSerThrAlaAsnGlu-464 473-AsnValIleAlaTyrLeu-478 515-SerGlyLeuSerLysAlaLeuAspValGly-524 Antigenic Index - Jameson-Wolf 15-AlaAsnTyrArgArgArgGluAsnLysAspLeuPhe-26 33-GlyGluTyrLeuAspGluLeuCysGluProAsnIle-44 48-IleGlyGluLysGlyThrGlyLysThr-56 64-AsnAsnPheTyrLys-68 75-LysPheValArgGluThrAspTyr-82 89-LysLysAlaArgHis-93 113-AsnGlnIleLysCysLysGluAsnGlyIle-122 131-LysAlaLeuAspGluAlaIleAsn-138 140-TyrTyrTyrGlyAlaPheAspProGluIle-149 157-GluAsnSerLysGluAlaAla-163 171-ValLysLeuGlyGluGluGluSerGln-179 184-ThrGluSerLysPhe-188 194-PheIleGluArgLysPheLysAεpAlaLeuSer-204 206-LeuLysLeuLysAspAsn-211 217-AspGlyIleAspIleArgProSerGlnIleProPhe-228 230-GluTyrHisGluCysValLys-236 251-ProSerIleLysAspSerLysGlyArgMet-260 267-ArgProAspIlePheAspSerLeuGlyLeuGlnAsnGlnAsnThrLysLeuGlnAspAsnSerVal-288 291-AspTrpArgThrAspTyrLysSerTyrArgSerSerLysIle-304 312-LeuArgThrGlnGlnGluLysGlnAspSerLeuGluLysGlyAsnSerTrpAspTyrTyrPheProTrpAsn AlaProAsnLeuHisAspGluTyrLysAsnLeu-346 353 -LeuArgLysSerTyrTyrArgProArgAspIle-363 371-GlnLysAsnLysLyεSerLysGluAspTyrValVal-382 384-GluAspPheAspAsnThrSerPheGlnArgGluTyrSer-396 412-SerGlnSerAspTyrGlnAsn-418 427-AsnGlyLysAspArgPheLysTyrSerAspPhe-437 439-LysAlaPheGluArgLeuLysLysHisLeuGln-449 454-GluIleProLysPhe-458 478-LeuAspAsnProGluAspGluThrLysPro-487 493-PheLysAspArgAsnTyrAlaAsnIleSerProLysIleLysThrGluThr-509 518-SerLysAlaLeuAsp-522 524-GlyThrProPheLysAsnLysGln-531 Hydrophilic Regions - Hopp-Woods 15-AlaAsnTyrArgArgArgGluAsnLysAspLeuPhe-26 34-GluTyrLeuAspGluLeuCysGlu-41 50-GluLysGlyThrGly-54 75-LysPheValArgGluThrAspTyr-82 89-LysLysAlaArgHis-93 115-IleLysCysLysGluAsnGlyIle-122 131-LysAlaLeuAspGluAlaIle-137 157-GluAsnSerLysGluAlaAla-163 171-ValLysLeuGlyGluGluGluSerGln-179 184-ThrGluSerLysPhe-188 194-PheIleGluArgLysPheLysAspAlaLeuSer-204 206-LeuLysLeuLysAspAsn-211 219-IleAspIleArgPro-223 230-GluTyrHisGluCysValLys-236 251-ProSerIleLysAspSerLysGlyArgMet-260 279-GlnAsnThrLysLeuGlnAsp-285 292-TrpArgThrAspTyrLysSerTyrArgSer-301 314-ThrGlnGlnGluLysGlnAspSerLeuGluLysGlyAsnSer-327 338-AsnLeuHisAspGluTyrLysAsn-345 356-SerTyrTyrArgProArgAspI1e-363 371-GlnLysAsnLysLysSerLysGluAspTyrValVal-382 384-GluAspPheAspAsn-388 427-AsnGlyLysAspArgPheLysTyr-434 439-LysAlaPheGluArgLeuLysLysHisLeuGln-449 479-AspAsnProGluAspGluThrLysPro-487 493-PheLysAspArgAsnTyr-498 503-ProLysIleLysThrGluThr-509 527-PheLysAsnLysGln-531 745 AMPHI Regions - AMPHI 9-SerValThrAlaValIle-14 33-AspValIleLeuAsnAsp-38 116-CysThrAsnPheIleLysLeuTrpAsnAlaValSer-127 145-GluLeuGluIleLeuVal-150 Antigenic Index - Jameson-Wolf 21-IleAsnLysLysThrSerLysGlnLysAlaThr-31 37-AsnAspTyrGlnAsp-41 43-GlnPheValGluAlaAspAsnHisIleSerProTyrIle-55 58-ThrAlaValAspAspAsnAsnAlaArg-66 73-TyrGlnAsnLysGlyGlyGlnTrpGluLysGluArgGlyHis-86 102-AsnSerGlyValLeuAspGluAspLeuPheLys-112 132-LysIleArgGluGluGluArgLysAspThrIlePheArgGluLeuGlu-147 156-AsnProLeuLysAlaSerAspLeu-163 Hydrophilic Regions - Hopp-Woods 23-LysLysThrSerLysGlnLysAlaThr-31 43-GlnPheValGluAlaAspAsnHis-50 58-ThrAlaValAspAspAsnAsnAlaArg-66 76-LysGlyGlyGlnTrpGluLysGluArgGlyHis-86 105-ValLeuAspGluAspLeuPheLys-112 132-LysIleArgGluGluGluArgLysAspThrIlePheArgGluLeuGlu-147 156-AsnProLeuLysAlaSerAspLeu-163 746 AMPHI Regions - AMPHI 10-LeuSerGlyTyrGluGlnLeuLys-17 42-LeuSerSerGlyProAlaGluGlnThrAla-51 72-SerAlaAlaAspLysProGlnAsp-79 94-SerGluProGluAεn-98 118-LeuGluAlaSerGluLysLeuGlnGlnAlaGluThrAlaLysThrAlaPro-134 153-AspThrValAlaValGlu-158 160-ProLysArgThrAlaGluThr-166 170-LysAlaGluArgThr-174 184-ThrLysThrAlaGluLysValAlaAspLysProLys-195 210-SerAlaValLysGluAlaLysLysAlaAspLysAlaGluSer-223 238-GluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLys-254 287-SerThrIleThrGluIleMetThr-294 307-TyrLysAsnAlaArgAspAlaGluArgAspLeu-317 Antigenic Index - Jameson-Wolf 1-MetSerGluAsnLysGlnAsnGluValLeuSerGlyTyrGluGlnLeuLysArgArgAsnArgArgArgLeuVa lThr-26 43-SerSerGlyProAlaGluGlnThrAlaGlyGluThrSerGlyValGluAsnLysAlaAlaGly-63 68-ProAlaLeuLysSerAlaAlaAspLysProGlnAspLeuAlaGlyGluAspLysProSerAlaAlaAspSerG luIleSerGluProGluAsnVal-99 108-GluArgLeuGluAspSerAsnIleLysGlyLeuGluAlaSerGluLysLeuGlnGlnAlaGluThrAlaLys ThrAlaProLyεGlnAlaLysGlnArgAlaAlaGluLysValProAlaThrAlaAspSerThrAspThrValAlaV alGluLysProLysArgThrAlaGluThrLysProGlnLysAlaGluArgThrAlaLysAlaLysProLysAlaLy sGluThrLysThrAlaGluLysValAlaAspLysProLysThrAlaAlaGluLysThrLysProAspThrAlaLys SerAspSerAlaValLysGluAlaLysLysAlaAspLysAlaGluSerLysLysThrAlaGluLysAspArgSerA spGlyLysLysHisGluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLysGluLysSerGl yLysLysAlaAla-262 266-GlyTyrAlaGluLysGluArgAlaLeuSerLeuGlnArgLysMetLysAlaAlaGlyIle-285 292-IleMetThrAspAsnGlyLysValTyrArgValLysSerSerAsnTyrLysAsnAlaArgAspAlaGluArg AspLeuAsnLysLeuArgVal-322 Hydrophilic Regions - Hopp-Woods l-MetSerGluAsnLysGlnAsnGluVal-9 14-GluGlnLeuLysArgArgAsnArgArgArgLeuVal-25 45-GlyProAlaGluGlnThrAlaGlyGluThrSerGlyValGluAsnLysAlaAlaGly-63 68-ProAlaLeuLysSerAlaAlaAspLysProGlnAspLeuAlaGlyGluAspLyεProSerAlaAlaAspSerG luIleSerGluProGluAsnVal-99 108-GluArgLeuGluAspSerAsnIleLysGlyLeuGluAlaSerGluLysLeuGlnGlnAlaGluThrAlaLys ThrAlaProLysGlnAlaLysGlnArgAlaAlaGluLysValProAlaThrAlaAspSerThrAsp-153 155-ValAlaValGluLysProLysArgThrAlaGluThrLysProGlnLysAlaGluArgThrAlaLysAlaLys ProLysAlaLysGluThrLysThrAlaGluLysValAlaAspLysProLysThrAlaAlaGluLysThrLysProA spThrAlaLysSerAspSer laValLysGluAlaLysLysAlaAspLysAlaGluSerLysLysThrAlaGluLy sAspArgSerAspGlyLysLysHisGluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLys GluLysSerGlyLysLysAlaAla-262 267-TyrAlaGluLysGluArgAlaLeuSerLeuGlnArgLysMetLysAlaAlaGlyIle-285 292-IleMetThrAspAsnGlyLysValTyrArgValLysSerSerAsnTyrLysAsnAlaArgAspAlaGluArg AspLeuAsnLysLeuArgVal-322 747 AMPHI Regions - AMPHI 24-AlaSerArgAspValSerLysSerAlaLysGlyTrp-35 Antigenic Index - Jameson-Wolf 8-TyrAlaAspLeuArgGlyLyεThrLysVal-17 23-GlyAlaSerArgAspValSerLysSerAlaLysGlyTrp-35 42-AsnValGlyLysGlnLeuThrAspSerValGlyLeuGluPheAspProTyrTyrArgHisLysThrIleTyrL ysProArgGluIleValLeuAspGlyAspLysThrLysMetGlyArgSerLysSerAsnGluTyrGly-88 97-SerGlnLeuLysSerLys-102 Hydrophilic Regions - Hopp-Woods 8-TyrAlaAspLeuArgGlyLysThrLysVal-17 23-GlyAlaSerArgAspValSerLysSerAlaLys-33 63-ThrIleTyrLysProArgGluIleValLeuAspGlyAspLysThrLysMetGlyArgSerLysSerAsnGluT yr-87 748 AMPHI Regions - AMPHI 22-GlyAlaValGlyAlaIleGlyGly-29 37-GlyGluThrAlaGluArgThrAlaGluSerGlnHis-48 82-SerAlaLysGlnLeuGluAsnLeuPheArgThrLeu-93 155-LeuGlnGluMetArgAspPheSerAsnAspLysLeuGlnLysSerTrp-170 188-GlnAlaAlaLeuArgAspIleIleLysHisThrValGln-200 250-GlyValAlaAlaAsnSer-255 257-AspGluProGluTrp-261 268-GlnAlaValArgLeuIleArgHisPheValGluPheTrpAspArg-282 310-GlnProAspPheAlaLysAspProGlu-318 334-ArgAspProGluPheLeu-339 390-LeuGluGluTyrIleSerProPhe-397 Antigenic Index - Jameson-Wolf l-MetSerLysLysGlnProAlaGlnProThrArgArgThrLeuPhe-15 30-TyrLeuGlyGlyLysLysGlnGlyGluThrAlaGluArgThrAlaGluSerGlnHisSerProGlnAla-52 80-AlaGlnSerAlaLysGlnLeuGluAsn-88 101-ThrGlnGlyGlyGluTyrGlnAspGlyAspAspLysLeuProProAlaGlySerGly-119 125-PheAsnProAspGlyLeuThr-131 139-ΞerLeuPheAspGlyArgPheGlyLeuLysAspLysLysProl1eHis-154 156-GlnGluMetArgAspPheSerAsnAspLysLeuGlnLysSerTrpCysAspGlyAspLeuSer-176 183-ThrProGluThrCys-187 208-IleAspGlyTrpGlnProLysSerGluProGlyAlaMetAla-221 226-LeuGlyPheArgAspGlyThrGlyAsnProLysValSerAspProLysThrAlaAspGlu-245 255-SerLeuAspGluProGluTrpAlaLysAsnGlySerTyrGlnAla-269 279-PheTrpAspArgThrProLeuGlnGluGlnThrAspIlePheGlyArgArgLysTyrSerGlyAlaProMet AεpGlyLysLysGluAlaAspGlnProAspPheAlaLysAspProGluGlyAspIleThrProLysAspSerHisI leArgLeuAlaAsnProArgAspProGluPheLeuLysLysHisArgLeuPheArg-346 348-AlaTyrSerTyrSerArgGlyLeuAlaSerSerGlyGlnLeu-361 385-LeuAsnGlyGluProLeuGluGluTyr-393 406-ProGlyValGluLysGlyGlyPhe-413 Hydrophilic Regions - Hopp-Woods l-MetSerLysLysGlnProAlaGlnProThrArgArgThrLeuPhe-15 32-GlyGlyLysLysGlnGlyGluThrAlaGluArgThrAlaGluSerGlnHiεSer-49 80-AlaGlnSerAlaLysGlnLeuGluAsn-88 104-GlyGluTyrGlnAspGlyAspAspLysLeuProPro-115 145-PheGlyLeuLysAεpLysLysProIleHis-154 156-GlnGluMetArgAspPheSerAsnAspLysLeuGlnLysSerTrpCysAspGlyAspLeu-175 211-TrpGlnProLysSerGluProGlyAlaMetAla-221 229-ArgAspGlyThrGlyAsnProLysValSerAspProLysThrAlaAsp-244 255-SerLeuAspGluProGluTrpAlaLys-263 283-ThrProLeuGlnGluGlnThrAspIlePheGlyArgArgLysTyrSer-298 301-ProMetAspGlyLysLysGluAlaAspGlnProAspPheAlaLysAspProGluGlyAspIleThrProLys AspSerHisIle-328 331-AlaAsnProArgAspProGluPheLeuLysLysHisArgLeuPheArg-346 388-GluProLeuGluGluTyr-393 407-GlyValGluLysGlyGly-412 749 AMPHI Regions - AMPHI 20-CysGlnProProGluAla-25 140-AlaAspLeuGluLysLeuSerGlnProLeuAla-150 157-GlnGlyGluValLysGluLeuVal-164 169-ThrPheThrGluAlaValLysAlaGlyAspIleGluLysAla-182 196-IleGluProIleAlaGluLeuPheSerGluLeuAspPro-208 224-AlaGlyPheThrGlyPheHisArg-231 243-SerGlyValLysGluIleAlaAlaLysLeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 274-ValGlyGlyAlaSerGluLeuIleGluGluValAlaGly-286 309-AspGlySerLysLysIleValAspLeuPheArgProLeu-321 337-PheLysGlnValAsnGluIleLeuAlaLys-346 351-AspGlyPheGluThrTyrAspLysLeuGlyGlu-361 366-AlaLeuGlnAlaSerIleAsnAlaLeuAlaGluAspLeuAlaGlnLeuArgGlyIleLeuGlyLeu-387 Antigenic Index - Jameson-Wolf 1-MetArgLysPheAsn-5 21-GlnProProGluAlaGluLysAlaAlaPro-30 32-AlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySer-44 50-AsnAspAsnAlaCysGluProMetGlu-58 70-1leLysAsnAsnSerGlyArgLysLeuGluTrpGluIle-82 87-MetValValAspGluArgGluAsnIleAla-96 98-GlyLeuSerAspLysMetThr-104 108-LeuProGlyGluTyrGluMet-114 120-ThrAsnProArgGlyLysLeuValValThrAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGlu LysLeuSer-146 158-GlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGlyAspIleGluLys AlaLysSerLeuPheAla-187 189-ThrArgValHisTyrGluArgIleGluProIle-199 204-SerGluLeuAspProValIleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGly-225 238-ValGluLysAspValSerGlyValLysGluIleAlaAla-250 252-LeuMetThrAεpValGluAlaLeuGlnLysGluIleAsp-264 269-ProProGlyLysValValGlyGlyAla-277 279-GluLeuIleGluGluValAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSer AspPheGlnAlaAsnValAspGlySerLysLysIleValAsp-316 322-IleGluAlaLysAsnLysAlaLeuLeuGluLysThrAspThrAsnPheLysGlnValAsn-341 345-AlaLysTyrArgThrLysAspGlyPheGluThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeu-36 7 374-LeuAlaGluAspLeuAlaGln-380 Hydrophilic Regions - Hopp-Woods 1-MetArgLysPheAsn-5 21-GlnProProGluAlaGluLysAlaAlaPro-30 32-AlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySer-44 52-AsnAlaCysGluProMetGlu-58 72-AsnAsnSerGlyArgLysLeuGluTrpGluIle-82 87-MetValValAspGluArgGluAsnIle-95 99-LeuSerAspLysMetThr-104 110-GlyGluTyrGluMet-114 122-ProArgGlyLysLeuValVal-128 131-SerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuSer-146 158-GlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGlyAspIleGluLys AlaLysSerLeuPheAla-187 189-ThrArgValHisTyrGluArgIleGluProIle-199 204-SerGluLeuAspProValIleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGly-225 238-ValGluLysAspValSerGlyValLysGluIleAlaAla-250 252-LeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 279-GluLeuIleGluGluValAlaGly-286 288-LysIleSerGlyGluGluAspArgTyrSerHis-298 308-ValAspGlySerLysLysIleValAsp-316 322-IleGluAlaLysAsnLysAlaLeuLeuGluLysThrAspThrAsnPhe-337 347-TyrArgThrLysAspGlyPheGluThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeu-367 374-LeuAlaGluAspLeuAlaGln-380 750 AMPHI Regions - AMPHI 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuLeuThrAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerAlaSerAlaAlaThrLeuThrValProThrAlaArgGlyAspAlaValValProLys AsnProGluArgValAlaValTyrAspTrpAlaAlaLeuAspThrLeuThrGluLeuGlyValAsnValGlyAlaT hrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLysAlaAlaThrValGlyThrLeuPheGluPr oAspTyrGluAlaLeuHisArgTyrAsnProGlnLeuVallleThrGlyGlyProGlyAlaGluAlaTyrGluGln LeuAlaLysAεnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyGluLysGlnMetG luThrLeuAlaArgllePheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnlleAspAlaLeuPheAlaGl nThrArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysValSerAlaPheGly ThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluG lyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProAspTrpIlePhellelleAspArgThrAl aAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValArgGlyThrAsnAlaTrpLys ArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlyAlaArgGlnLeuIleGlnAlaAlaG luGlnLeuLysAlaAlaPheLysLysAlaGluProValAlaAlaGlyLysLys-321 Antigenic Index - Jameson-Wolf 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuLeuThrAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerAlaSerAlaAlaThrLeuThrValProThrAlaArgGlyAspAlaValValProLys AsnProGluArgValAlaValTyrAspTrpAlaAlaLeuAspThrLeuThrGluLeuGlyValAsnValGlyAlaT hrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLysAlaAlaThrValGlyThrLeuPheGluPr oAspTyrGluAlaLeuHisArgTyrAsnProGlnLeuVallleThrGlyGlyProGlyAlaGluAlaTyrGluGln LeuAlaLysAsnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyGluLyεGlnMetG luThrLeuAlaArgllePheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnlleAspAlaLeuPheAlaGl nThrArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysValSerAlaPheGly ThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluG lyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProAspTrpIlePhellelleAspArgThrAl aAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValArgGlyThrAsnAlaTrpLys ArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlyAlaArgGlnLeuIleGlnAlaAlaG luGlnLeuLysAlaAlaPheLysLysAlaGluProValAlaAlaGlyLysLys-321 Hydrophilic Regions - Hopp-Woods 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuLeuThrAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerAlaSerAlaAlaThrLeuThrValProThrAlaArgGlyAspAlaValValProLys AsnProGluArgValAlaValTyrAspTrpAlaAlaLeuAspThrLeuThrGluLeuGlyValAsnValGlyAlaT hrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLyεAlaAlaThrValGlyThrLeuPheGluPr oAspTyrGluAlaLeuHisArgTyrAsnProGlnLeuVallleThrGlyGlyProGlyAlaGluAlaTyrGluGln LeuAlaLysAsnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyGluLysGlnMetG luThrLeuAlaArgllePheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnlleAspAlaLeuPheAlaGl nThrArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysValSerAlaPheGly ThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluG lyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProAspTrpIlePhellelleAspArgThrAl aAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValArgGlyThrAsnAlaTrpLys ArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlyAlaArgGlnLeuIleGlnAlaAlaG luGlnLeuLysAlaAlaPheLysLysAlaGluProValAlaAlaGlyLysLyε-321 751 AMPHI Regions - AMPHI H-AlaAspArgAlaValArgSerAlaThr-19 59-IleGlnAspThrAsn-63 82-LeuSerAsnAlaAla-86 139-LeuAsnAsnLysValPheGlnGlyTyr-147 156-LeuAsnGlnAspIleTyrArgGluValGlnLysMetGly-168 215-AsnValGlnAsnAspTyrAlaAspValLeu-224 281-SerTyrPheAlaGluValProLysAlaGlyThrLysGluPheAspAspTyrValLysIleTrpGlyGlu-30 3 Antigenic Index - Jameson-Wolf 9-ThrGlnAlaAspArgAlaValArg-16 18-AlaThrAlaProLys-22 29-LysIleIleAspGluLysThrGlyLysValSerPheAspThrArgGlnIle-45 50-AspLeuSerLysGluGluLeuAlaSerIleGlnAspThrAsnGlyLysVal-66 72-ProGlyIlePheAsnAsnArgGluAspSerLeuSerAsnAlaAlaLysGlnAsnArgAsnSerThrAsnGlyS er-96 104-ProProThrGlyLysTyrLysSerAspSerAsnAsnLysIleLys-118 137-AspGlnLeuAsnAsnLys-142 147-TyrLeuProLysThrAsnSerGluLysLeuAsnGlnAspIleTyrArgGluValGlnLysMetGlyAsnGly TrpSerValAspThrSerAsnHisSerArgGlyGlyIle-183 190-LysAspTrpValAsnAsnGlnLysGlnAsnGly-200 203-ProIleArgLysAlaArgPhe-209 214-ThrAsnValGlnAsnAspTyrAlaAspValLeuGlnLysAsnGlyTyr-229 233-GlyAlaAspGlyLysThrTyrAsnSerGlySer-243 247-ValHisAspLysAspPheValGlyAsnLys-256 263-GlyThrAsnAspThrThrGlnGlyThrCysLysGlyLeuCys-276 286-ValProLysAlaGlyThrLysGluPheAspAspTyrVal-298 304-ValGluTyrAspAlaGlnGlyLysProIleAsnLysSerLysProIleLeuValGluProAεnLysThrLys AspAsnGluLysTyrGluLysGluAlaPhe-337 Hydrophilic Regions - Hopp-Woods 10-GlnAlaAspArgAlaValArg-16 18-AlaThrAlaProLys-22 29-LysIleIleAspGluLysThrGlyLysValSerPheAspThr-42 50-AspLeuSerLysGluGluLeuAlaSer-58 60-GlnAεpThrAsnGly-64 76-AsnAsnArgGluAspSerLeuSerAsnAlaAlaLysGlnAsnArgAsnSerThrAsn-94 105-ProThrGlyLysTyrLysSerAspSerAsnAsnLysIleLys-118 151-ThrAsnSerGluLysLeuAsnGlnAspIleTyrArgGluValGlnLysMet-167 175-ThrSerAsnHisSerArgGlyGlyIle-183 196-GlnLysGlnAsnGly-200 203-ProIleArgLysAlaArgPhe-209 219-AspTyrAlaAspValLeuGln-225 234-AlaAspGlyLysThrTyrAsn-240 247-ValHisAspLysAspPheVal-253 265-AsnAspThrThrGlnGlyThrCys-272 286-ValProLysAlaGlyThrLysGluPheAspAspTyrVal-298 304-ValGluTyrAspAlaGlnGlyLysProIleAsnLysSerLysProIleLeu-320 322-GluProAsnLysThrLysAspAsnGluLysTyrGluLysGluAlaPhe-337 752-2 AMPHI Regions - AMPHI 6-GluArgMetThrGlnIleAlaLysLeuLeuAsnSerSer-18 29-PheLeuThrGluIleLysAspTyrSerGluPhe-39 51-TrpAspLysPheArgArgl1e-57 69-ValLysGluSerArgLysLysIleGlnLysProIleAsp-81 105-LysSerCysGlySerSerIleGly-112 114-SerSerLeuGlyGlyPheGly-120 145-GlyAlaAlaThrThrArgLysValAlaLysAspMetLeuLysSerGln-160 194-IleLeuAspLeuHisArgIleAlaThrSer-203 233-GlnProProProHisGly-238 240-ValHisThrLeuMetGluGluVal-247 254-ThrTyrAspGlyValGluAsnProPheIleHisProValValGlnAlaIle-270 272-LeuHisPheLeuIleGlyTyrIleHisPro-281 309-IleSerIleSerArgLeuLeuLysAsnAlaProAlaGlnTyr-322 347-IleLysArgAlaValAlaAspLeuGluHis-356 371-AlaIleAlaGlnTyrThrGluLysIleGlyLysLeu-382 390-LeuGlnLysAlaValGluGluSerGly-398 422-SerLysLeuGlyGluTyrArgPhe-429 435-SerGlyAsnAlaLeuGluTyrValAlaPro-444 Antigenic Index - Jameson-Wolf 4-LeuThrGluArgMetThrGln-10 15-LeuAsnSerSerAlaAsnAsnProAspIleAspIleProAspPheLeuThrGluIleLysAspTyrSerGlu- 38 40-SerValThrAspGluAsnGlyThr-47 52-AspLysPheArgArgIleHiεThrGluAspThrArgMetLysTrpArgAlaValLysGluSerArgLysLysI leGlnLysProIleAsp-81 92-IleProAspSerLeuGln-97 102-LeuIleAspLysSerCysGlySerSerIleGly-112 117-GlyGlyPheGlyArgSerGluGlnAsnArgPheLeu-128 147-AlaThrThrArgLysValAlaLysAspMetLeuLysSerGlnArgLysProLysThrLysAspGluIle-16 9 179-LysLysAlaValGluLeuLysAsnThr-187 204-AsnAlaIleGluAsnLysAlaGluProGlyGlnPheArgGlnAspAspGluIlePhe-222 226-IleAsnGlyAsnSerLeuTyrGlnProProProHisGly-238 253-AsnThrTyrAspGlyValGluAsnProPhe-262 280-HisProPheGlyAspGlyAsnGlyArgThrAlaArg-291 313-ArgLeuLeuLysAsnAlaPro-319 330-GluThrAspAspLeuAsp-335 342-TyrGlnCysAspIleIleLys-348 358-IleSerAspLysGlnLysHisGlnGlnGluPheLyεAla-370 375-TyrThrGluLysIleGlyLysLeuAsnGlnArgGln-386 392-LysAlaValGluGluSerGlyLys-399 415-AsnThrAlaArgSerAspLeuSerLysLeuGlyGluTyrArgPhe-429 433-PheLysSerGlyAsnAlaLeu-439 445-GlnAspLeuLeuGluArgLeuGluLysLys-454 Hydrophilic Regions - Hopp-Woods 4-LeuThrGluArgMetThrGln-10 19-AlaAsnAsnProAspIleAspIle-26 31-ThrGluIleLysAspTyrSerGlu-38 40-SerValThrAspGluAsnGly-46 52-AspLysPheArgArgIleHisThrGluAspThrArgMetLysTrpArgAlaValLyεGluSerArgLysLysI leGlnLysProIle-80 102-LeuIleAspLysSerCysGly-108 120-GlyArgSerGluGlnAsnArgPheLeu-128 147-AlaThrThrArgLysValAlaLysAspMetLeuLysSerGlnArgLysProLysThrLysAspGluIle-16 179-LysLysAlaValGluLeuLysAsn-186 204-AsnAlaIleGluAsnLysAlaGluProGlyGlnPheArgGlnAspAspGluIlePhe-222 283-GlyAspGlyAsnGlyArgThrAlaArg-291 330-GluThrAspAspLeuAsp-335 358-IleSerAspLysGlnLysHisGlnGlnGluPheLysAla-370 375-TyrThrGluLysIleGlyLysLeuAsnGlnArgGln-386 392-LysAlaValGluGluSerGlyLys-399 416-ThrAlaArgSerAspLeuSerLysLeuGlyGlu-426 446-AspLeuLeuGluArgLeuGluLysLys-454 753 AMPHI Regions - AMPHI 44-IleValGluMetMetThrTyrIleLeu-52 75-TrpAlaTyrPheAspGluValAlaGln-83 109-GlnTrpPheAlaProLeu-114 121-ArgSerAlaValArgGlnLeu-127 129-ProSerThrThrValArgAla-135 Antigenic Index - Jameson-Wolf 13-LysLeuTyrProAsnGluGlnTrpAsnGluSerGluAla-25 34-TyrGlnSerProThrHisArgGln-41 55-LeuLysAsnGlyGln-59 64-CysLysGlyThrGlnProIleGly-71 85-HisTyrLeuGluSerAspArgHisLeuArgAspAsnSerAspTrpAsnCysGlyAspAsnIle-105 112-AlaProLeuGlyHisSerHisGlnMetArgSerAlaVal-124 136-LeuTyrHisLysGlySerAspLysGlyLeuArg-146 Hydrophilic Regions - Hopp-Woods 19-GlnTrpAsnGluSerGluAla-25 87-LeuGluSerAspArgHisLeuArgAspAsnSerAsp-98 139-LysGlySerAspLysGlyLeuArg-146 754 AMPHI Regions - AMPHI 29-ArgIleGlyThrLeuGluLysGlyAlaMet-38 67-MetProHisIlePheAlaGlnTyrPheProGluGlyPheLeuAsp-81 108-ArgGluThrLeuGlyArg-113 121-ProLeuPheAsnGluTrpIleAspGlyLeuGlu-131 152-PheGlnGlnTyrMetAlaGluIle-159 161-HisHisGlyArgPheValSerValSer-169 181-ArgArgAsnThrLys-185 189-SerTyrIleAlaLysGly-194 249-MetGluAspPheThrSerLeuArgGln-257 269-AlaAlaIleAlaGlnIleIleArgGlnIleSerGlyArgProAsp-283 288-HisPhePheAsnGlnLeuAlaAla-295 324-ValTyrAspValLeuAspThr-330 336-GlyThrGlnGlyIlePheAspAlaTyrAsp-345 399-TyrSerAspValLeu-403 Antigenic Index - Jameson-Wolf 8-ValSerGlyAsnArgMetArgLysProArg-17 25-AlaAsnAspGluArgIleGlyThrLeuGluLysGlyAla-37 43-TyrAspAsnProAsnSerSerLeu-50 54-HisTyrGlnAspArgSerLysVal-61 75-PheProGluGlyPheLeu-80 93-AlaProPheGluAspAsnGluMetLeu-101 114-IleHisValArgCysAsnAspProLeuPhe-123 130-LeuGluMetLysAsnProArgIleLeuThrGluArgAspLeuLeu-144 163-GlyArgPheValSer-167 170-GlyIleGlnGlnLysMetSerLeuAspAlaIleArgArgAsnThrLysGlnThrAla-188 194-GlyPheAspAlaSerGluTyrProCys-202 224-ThrSerLeuSerGluAspSerSer-231 236-ArgArgPheAspValSerGluGlnGlyTyr-245 250-GluAspPheThrSer-254 256-ArgGlnTyrSerValGluAspLysTyrLysGlySerTyr-268 278-IleSerGlyArgProAspGluAspLeu-286 299-LeuLysAsnGlyAspAlaHisLeu-306 315-AspGluTyrAspVal-319 343-AlaTyrAspAspThrLeu-348 352-LeuThrAsnHisGlyLysLysThrTyrProSerLysAsnThr-365 369-PheAlaGluLysTyrCysAspLeuGlyArgGluAspAlaSerPhe-383 389-ValGlnAlaLysGluGlnVal-395 399-TyrSerAspValLeuArgGluAsnGluTrpLeu-409 415-PheIleProAspGluAsnGluGluGlyLeu-424 Hydrophilic Regions - Hopp-Woods 10-GlyAsnArgMetArgLysProArg-17 25-AlaAsnAspGluArgIleGlyThrLeuGluLysGlyAla-37 55-TyrGlnAspArgSerLysVal-61 93-AlaProPheGluAspAsnGluMetLeu-101 114-IleHisValArgCysAsnAsp-120 130-LeuGluMetLysAsnProArgIleLeuThrGluArgAspLeuLeu-144 175-MetSerLeuAspAlaIleArgArgAsnThrLysGln-186 194-GlyPheAspAlaSerGlu-199 225-SerLeuSerGluAspSerSer-231 236-ArgArgPheAspValSerGlu-242 250-GluAspPheThrSer-254 258-TyrSerValGluAspLysTyrLysGly-266 278-IleSerGlyArgProAspGluAspLeu-286 300-LysAsnGlyAspAlaHisLeu-306 315-AspGluTyrAspVal-319 354-AsnHisGlyLysLysThrTyrProSer-362 369-PheAlaGluLysTyrCysAspLeuGlyArgGluAspAlaSerPhe-383 389-ValGlnAlaLysGluGlnVal-395 401-AspValLeuArgGluAsnGluTrpLeu-409 417-ProAspGluAsnGluGluGlyLeu-424 755 AMPHI Regions - AMPHI 22-AsnAsnTyrThrAsnAlaTyrSerAspIleLysThrIle-34 38-HisGlyPheGluAsnIleGlnGly-45 75-SerCysIleSerAsnIleLysPhe-82 124-GluGlnIleAsnGlnValLeu-130 Antigenic Index - Jameson-Wolf 10-MetAspThrAsnCysLeuLysAspAsnTyrHisGlyAsnAsnTyrThrAsnAlaTyrSerAsp-30 42-AsnIleGlnGlySer-46 48-TyrLeuGlyArgGluGlyIleSerGluAlaHis-58 83-TyrArgLeuGluSerAspLeu-89 108-ArgValGluGlnLeuArg-113 120-GlyLeuSerAspGluGlnIle-126 129-ValLeuGluLysGlnLysPheGluLeuGluSerProAsnLeuLys-143 Hydrophilic Regions - Hopp-Woods 10-MetAspThrAsnCysLeuLysAspAsnTyrHis-20 49-LeuGlyArgGluGlyIleSerGluAlaHis-58 83-TyrArgLeuGluSerAspLeu-89 108-ArgValGluGlnLeuArg-113 120-GlyLeuSerAspGluGlnIle-126 129-ValLeuGluLysGlnLysPheGluLeuGluSerProAsnLeu-142 756 AMPHI Regions - AMPHI 6-AlaGlnThrLeuValGluIleGlnAspΞerLeuTyrArgValValSerThrVal-23 29-AsnLeuLysArgLeuThr-34 57-AspPheLysGluThrLeuValArgPheGlyArgAspMetLeuGlnAspMetPro-74 98-TyrLeuGluTyrLeuLysGlnValAlaSer-107 113-GluArgLeuTyrAsnAlaValAspArgLeuAlaGluSerGlnGluArg-128 130-ThrSerAlaIleLeu-134 136-GlyAlaArgGlyAlaAspPhe-142 Antigenic Index - Jameson-Wolf ll-GluIleGlnAspSerLeuTyr-17 24-GlnTyrGlyAspAspAsnLeuLysArgLeuThrAlaAspLysArgLysGlnTyr-41 45-PheLysIleSerGluGlySerThrArgValGluSerAspPheLysGluThrLeu-62 65-PheGlyArgAspMetLeuGlnAspMetProProLysIleArgSer-79 105-ValAlaSerGluGlyTyrGlnThrGluArgLeuTyrAsnAlaValAspArgLeuAlaGluSerGlnGluArg IleThr-130 135-LysGlyAlaArgGlyAlaAsp-141 144-GlnIleGlyArgArgSerTyrSerArgGluAspIleSerGluAlaAsnArgArgAlaGluArgValProTyr -167 171-LeuValSerAspGlyAsn-176 182-SerAspIleGlyAsp-186 Hydrophilic Regions - Hopp-Woods ll-GluIleGlnAspSerLeu-16 25-TyrGlyAspAspAsnLeuLysArgLeuThrAlaAspLysArgLysGlnTyr-41 45-PheLys11eSerGluGlySerThrArgValGluSerAspPheLysGluThrLeu-62 65-PheGlyArgAspMetLeuGln-71 73-MetProProLysIleArgSer-79 114-ArgLeuTyrAsnAlaValAspArgLeuAlaGluSerGlnGluArgIleThr-130 135-LysGlyAlaArgGlyAlaAsp-141 144-GlnIleGlyArgArgSerTyrSerArgGluAspIleSerGluAlaAsnArgArgAlaGluArgValProTyr -167 757 AMPHI Regions - AMPHI 47-AspTyrGlnSerAlaAlaAsnLys-54 79-AsnLeuLeuHisAspPheSerAspGlyLeu-88 97-LysAlaAspLysIleThr-102 115-GlnLysAlaGluLysLeuSerLysAlaAla-124 140-ArgAspThrGlyAsp-144 154-AsnAlaGlnLysGluProThrArgGluTrpAla-164 Antigenic Index - Jameson-Wolf 16-AlaCysGlySerGlnSerGluGluGlnProAlaSerAlaGlnProGlnGluGlnAlaGlnSerGluLeuLysT hrMetPro-42 46-ThrAspTyrGlnSerAlaAlaAsnLysGlyLeuAsnAspGlnLysThrGlyLeuThrLeu-65 73-AspAsnAlaGluGlyLysAsnLeuLeuHiεAspPheSerAspGlyLeu-88 93-ValAspThrAspLysAlaAspLysIleThrAla-103 108-TrpAsnThrAspAlaMetProGlnLysAlaGluLysLeuSerLys-122 132-AlaProGluAspArgThrMetLeuArgAspThrGlyAspGlnIleGluMetAlaIleAspSerHisAsnAla GlnLysGluProThrArgGluTrpAlaArgGlyGlyIle-168 Hydrophilic Regions - Hopp-Woods 19-SerGlnSerGluGluGlnProAla-26 29-GlnProGlnGluGlnAlaGlnSerGluLeuLysThr-40 50-SerAlaAlaAsnLysGlyLeuAsnAspGlnLysThr-61 73-AspAsnAlaGluGlyLysAsnLeu-80 93-ValAspThrAspLysAlaAspLysIleThrAla-103 112-AlaMetProGlnLysAlaGluLysLeuSerLys-122 132-AlaProGluAspArgThrMetLeuArgAspThrGlyAspGlnIleGluMetAlaIle-150 152-SerHisAsnAlaGlnLysGluProThrArgGluTrpAlaArg-165 758 AMPHI Regions - AMPHI 15-AlaThrLeuAlaAspGluLeuGlnTyrVal-24 53-AlaGluValAlaAla-57 60-GlnThrValIleSerGluIleValArgArgHisThr-71 87-ProTyrLeuGlyGlyLeuProGluAlaLeuHisThr-98 125-PheAlaSerProGlyGlyTrpGlnIleIleGly-135 Antigenic Index - Jameson-Wolf 9-ArgPheAspThrAspLeu-14 32-AspHisGlnGlyLysLeuVal-38 44-TyrGlyGlyGluTyrGlyProAspLeuAlaGlu-54 66-IleValArgArgHisThrAla-72 96-LeuHisThrProArgArgAlaValProArgThrSerValPro-109 115-IleGlyGlySerGln-119 145-AspLeuAsnProPro-149 154-AlaGlyAspGlnValArgPheValAlaGluArgIleGluPro-167 Hydrophilic Regions - Hopp-Woods 10-PheAspThrAspLeu-14 32-AspHisGlnGlyLysLeuVal-38 48-TyrGlyProAspLeuAlaGlu-54 66-IleValArgArgHiεThr-71 97-HisThrProArgArgAlaValPro-104 156-AspGlnValArgPheValAlaGluArgIleGluPro-167 759 AMPHI Regions - AMPHI 8-ProPheCysSerValLeuSerThrLeuGlyLeu-18 35-TyrGlnTyrPheArgAspPheAlaGlu-43 63-LysIleLeuGlyArgValLeuAsnGlyIlePro-73 94-TyrValAsnSerVal-98 140-ArgLeuAsnLysLeuValThrGluIle-148 185-ThrGlnGlnValArgLysAlaAsp-192 207-GlyGlyThrProLeu-211 261-LeuSerThrTyrAlaGlyPheAspAsnPhePheAsnLys-273 282-IleArgSerThrIle-286 313-ThrLeuGlnGlyLeu-317 408-LysGlyAspArgLeuSerLysLeuGlyAla-417 446-AlaSerAspGlySerLysGlnAla-453 548-ValTyrGluTyrIle-552 597-GluGlnValAlaGlnAlaGlu-603 764-LysThrProGluCysTyrArgSerTyrHisSer-774 788-GluAsnTyrArgAlaLeu-793 820-SerIleArgAlaGlyLys-825 878-ThrLeuAspGlyPheGlyThrPheArgPheLeuThrGlyl1e-891 921-ProGlnThrThrGlu-925 948-TyrAlaAspLeuGlyAlaTyr-954 967-LeuTyrAsnProLeuLys-972 992-TyrAsnGlnLeuGlnAlaThrAspIleSerArgGlnValGln-1005 1013-GlnAlaLeuGlnAlaTrpGlnAsnSerGln-1022 1040-LysGlnThrAspProLeuThrGlylleLeuThr-1050 1062-SerAlaAspIleCysArgGlnValAlaLysAlaAlaAspThr-1075 1084-GluLeuAspThrTyr-1088 1102-AlaArgGlnGlyGlyAspAlaGlnAlaValGluThrAlaArgHisAlaTyrLeuAsnAlaLeuAsnArgLe uSerArgGlnIleHisSerLeu-1132 1139-IleArgMetProAsnLeuAlaGluLeuIleSerArgSerAlaAsnThrAla-1155 1168-GlnAlaGlyArgArgIleAspArgHisLeuThrAspPro-1180 1199-GlyThrHisArgProTyrGlnGlnThrThrAsn-1209 1234-ThrAsnAsnArgPheAspGlu-1240 1328-GluIleAsnSerProAlaGlnIle-1335 1346-AspLysThrValGlu-1350 1385-GlnAlaAlaHisGlyThrLeu-1391 Antigenic Index - Jameson-Wolf 29-ValArgAsnAspValAspTyrGlnTyr-37 40-AspPheAlaGluAsnLysGlyAla-47 56-SerIleGlnAspLysGlnGlyLysIleLeu-65 73-ProMetProAspPheArgValSerAsnArgGlnThrAla-85 110-GlyAsnAspThrGlnAsnProGluGluGlnAlaTyr-121 125-LeuValSerArgAsnProHisProAspTyrAspTyrHisLeuProArgLeuAsnLysLeuValThr-146 148-IleSerProThrAla-152 160-GlyAsnGlyGlnProLysAla-166 168-AlaTyrLeuAspThrAspArgPhePro-176 181-LeuGlySerGlyThrGlnGlnValArgLysAlaAspGlyThrArgThrArgThrAlaPro-200 206-ThrGlyGlyThrProLeuLys-212 226-SerLeuThrAspGlnProLeuAsn-233 238-AlaGlyAspSerGlySerPro-244 249-AspLysHisGluAsnArg-254 285-ThrIleArgGlnTyrGluThrArgLeuAspVal-295 303-IleTrpArgAspAsnGlyAsnGlyAεnSerThr-313 316-GlyLeuAεnGluArgIleThr-322 327-AsnProSerLeuAlaProGlnAsnAspSerArgHisMetProSerGluAspAlaGlyLys-346 350-LeuSerSerArgPheAspAsnLysThr-358 364-AsnIleAsnGlnGlyAla-369 382-GlyLysAsnHisThr-386 394-ValAlaAspGlyLysArgValPhe-401 404-ValSerAsnProLysGlyAspArgLeuSerLysLeuGlyAla-417 424-GlyGlnGlyIleAsnGlnGlyAspIleSerIleGlyGluGlyThr-438 444-LysAlaAlaSerAspGlySerLyεGlnAla-453 459-IleThrSerGlyArgGlyThr-465 469-AlaAspSerGlnGlnIleLysProGluAsn-478 483-PheArgGlyGlyArgLeuAεpLeuAεnGlyAsnAsnLeu-495 501-ArgHisAlaAspGlyGlyAla-507 512-HisAsnProAspGlnAlaAla-518 528-LeuSerProGluHisValGlu-534 538-TrpGlyAsnArgProGlnGlyAsn-545 553 -AsnProHisArgAsnArgArgThrAsp-561 566-LysProGlyGlyAsnProArgGlu-573 577-LeuAsnMetLysAsnSerThrSer-584 589-GlyAsnAsnArgGlnGlnAlaAlaGluGlnValAlaGlnAlaGluAsnAlaArgProAspLeu-609 614-GlyTyrLeuGlyGluAsnAlaGlnThrGlyLysAlaAlaProSerTyrSerLysThrAsnGluAlaAlaIle GluLysThrArgHis-642 650-GlyArgProGluTyrArgTyrAsnGly-658 664-TyrArgProLysArgThrAspSer-671 677-GlyGlyMetAsnLeuAsnGly-683 694-ValSerGlyArgProValProHisAlaTyrAspHisGlnAlaLyεArgGluProValLeuGluAsnGluTrp ThrAspGlySerPheLysAla-724 726-ArgPheThrLeuArgAsnHisAla-733 736-ThrAlaGlyArgAsnThrAlaHisLeuAspGlyAspIleThr-749 761-ThrGlnGlyLysThrProGluCysTyrArgSerTyrHisSerGlySerThrHis-778 785-LeuLysAlaGluAsnTyrArg-791 796-ThrGlnValArgGlyAspIleThrLeuAsnAspArgSerGluLeuArgLeuGlyLys-814 820-SerIleArgAlaGlyLysAspThrAlaValArgMetGluAlaAspSerAsnTrpThr-838 840-SerGlnSerSerHisThrGly-846 859-ProAspPheAlaAsnAsnThrHisAsnAsnArgPheAsn-871 877-GlyThrLeuAspGly-881 891-IleValArgLysGlnAsnAlaProProLeuLysLeuGluGlyAspSerArgGlyAla-909 914-ValLysAsnThrGlyGlnGluProGlnThrThrGluSer-926 932-LeuAsnProLysHisSerHisGln-939 957-1leLeuArgLysAsnAsnAsnGlyTyr-965 969-AsnProLeuLysGluAlaGluLeuGlnIleGluAlaThrArgAlaGluHisGluArgAsnGlnGlnAla-99 1 999-AspIleSerArgGlnValGlnHisAspSerAspAlaThrArgGlnAla-1014 1018-TrpGlnAsnSerGlnThrGluLeuAlaArgIleAspSerGln-1031 1039-LeuLysGlnThrAspProLeuThr-1046 1064-AspIleCysArgGlnValAlaLysAlaAlaAspThrAsnAsp-1077 1083-ThrGluLeuAspThrTyrIleGluArgValGluMetAlaGluSerGluLeuAspLysAlaArgGlnGlyGl yAspAlaGlnAla-1110 1123-AsnArgLeuSerArg-1127 1147-LeuIleSerArgSerAlaAsnThrAlaValSerGlu-1158 1160-AlaAlaTyrAsnThrGlyArgGlnGlnAlaGlyArgArgIleAspArgHisLeuThrAspProGlnGlnGl nAsn-1184 1188-GluThrGlyThrGlnGlnThrAspTyrHisSerGlyThrHisArgProTyrGlnGlnThrThrAsn-1209 1219-IleThrAspArgLeuSer-1224 1229-LeuThrAspGluArgThrAsnAsnArgPheAspGluGlyValSerAlaArgAsnArgSerAsnGly-1250 1255-ValLysGlyGluAsnGlyAla-1261 1269-GlyTyrΞerAsnSerArgThrArgPheThrAspTyrAspGlyAlaAlaValArg-1286 1288-HisAlaTrpAspAlaGlyIleAsnThrGlyIleLysIleAspThrGlyIle-1304 1313-Argl1eAsnArgSerAsnGlyAsnArgTyrVal-1323 1326-GlyAlaGluIleAsnSerProAlaGlnIleGln-1336 1343-IleArgLeuAspLysThrValGlu-1350 1360-PheSerSerAspTyrTyrHisThrArgGlnAsnSerGlySerAla-1374 1376-SerValAsnAspArgThrLeu-1382 1398-AlaGlyTyrLysGlyTrpAsn-1404 1411-TyrGlyLysAspSerAsnThrAlaArgHisLysGlnAlaGly-1424 Hydrophilic Regions - Hopp-Woods 29-ValArgAsnAspValAsp-34 40-AspPheAlaGluAsnLysGly-46 56-SerIleGlnAspLysGlnGlyLysIleLeu-65 75-ProAspPheArgValSerAsnArgGlnThr-84 lll-AsnAspThrGlnAsnProGluGluGlnAlaTyr-121 129-AsnProHisProAspTyr-134 140-ArgLeuAsnLysLeuValThr-146 162-GlyGlnProLysAla-166 170-LeuAspThrAspArg-174 186-GlnGlnValArgLysAlaAspGlyThrArgThrArgThr-198 249-AspLysHisGluAsn-253 285-ThrIleArgGlnTyrGluThrArgLeuAspVal-295 306-AspAsnGlyAsnGly-310 317-LeuAsnGluArgIleThr-322 332-ProGlnAsnAspSerArgHisMetProSerGluAspAlaGlyLys-346 352-SerArgPheAspAsnLysThr-358 395-AlaAspGlyLysArg-399 406-AsnProLysGlyAεpArgLeuSerLys-414 444-LysAlaAlaSerAspGlySerLysGlnAla-453 472-GlnGlnIleLysProGlu-477 484-ArgGlyGlyArgLeuAspLeuAsnGly-492 501-ArgHisAlaAspGlyGly-506 555-HisArgAsnArgArgThrAsp-561 568-GlyGlyAsnProArgGlu-573 591-AsnArgGlnGlnAlaAlaGluGlnValAlaGlnAlaGluAsnAlaArgProAsp-608 619-AsnAlaGlnThrGlyLysAlaAlaProSerTyrSerLysThrAsnGluAlaAlaIleGluLysThrArgHis -642 652-ProGluTyrArgTyr-656 664-TyrArgProLysArgThrAspSer-671 705-HisGlnAlaLysArgGluProValLeu-713 736-ThrAlaGlyArgAsn-740 744-LeuAspGlyAspIleThr-749 764-LysThrProGluCysTyrArg-770 785-LeuLysAlaGluAsnTyrArg-791 797-GlnValArgGlyAspIleThrLeuAsnAspArgSerGluLeuArgLeuGlyLys-814 822-ArgAlaGlyLysAspThrAlaValArgMetGluAlaAspSer-835 891-IleValArgLysGlnAsnAlaPro-898 900-LeuLysLeuGluGlyAspSerArgGly-908 916-AsnThrGlyGlnGluProGlnThrThrGlu-925 934-ProLysHisSerHis-938 957-11eLeuArgLysAsnAsnAsn-963 970-ProLeuLysGluAlaGluLeuGlnIleGluAlaThrArgAlaGluHisGluArgAεnGlnGln-990 1004-ValGlnHisAspSerAspAlaThrArgGlnAla-1014 1021-SerGlnThrGluLeuAlaArgIleAspSer-1030 1039-LeuLysGlnThrAspPro-1044 1064-AspIleCysArgGlnValAlaLysAlaAlaAspThrAsnAsp-1077 1087-ThrTyrIleGluArgValGluMetAlaGluSerGluLeuAspLysAlaArgGlnGlyGlyAεpAlaGlnAl a-1110 1164-ThrGlyArgGlnGlnAlaGlyArgArgIleAspArgHisLeuThrAspProGlnGln-1182 1200-ThrHisArgProTyrGln-1205 1219-IleThrAspArgLeuSer-1224 1229-LeuThrAspGluArgThrAsnAεnArgPheAspGluGlyValSerAlaArgAsnArgSerAsnGly-1250 1272-AsnSerArgThrArgPheThrAspTyrAspGlyAlaAlaValArg-1286 1298-IleLysIleAspThr-1302 1313-ArgIleAsnArgSerAsnGly-1319 1326-GlyAlaGluIleAsnSer-1331 1343-IleArgLeuAspLysThrValGlu-1350 1376-SerValAsnAspArgThrLeu-1382 1411-TyrGlyLysAspSerAsnThrAlaArgHisLysGlnAlaGly-1424 760 AMPHI Regions - AMPHI 16-ThrValLeuAlaAlaLeuSerSer-23 29-GlnThrGluGlyLeu-33 40-GlyGlnArgSerTyr-44 58-PheAlaAlaThrValGlyThrLys-65 67-ProAlaSerLeuArgGluIleProGlnSerVal-77 88-ArgAsnValAspThrPheAspGlnLeuAlaArg-98 131-ProAlaGlnMetGlnSerIleAsnGlyThrLeuProAsnLeuPheAlaPheAspArgValGluValMetArg GlyProSerGlyLeuPheAspSerSerGlyGluMetGlyGlylleValAsnLeuValArgLysArgProThrLysA laPheGlnGlyHiεAlaAlaAla-187 190-GlyThrHisLysGln-194 277-SerLeuProGlnHis-281 296-HisAspValPheAlaAspLeuLysHis-304 334-LeuAsnAsnThrGlyGlnAla-340 381-ArgLeuArgSerThr 385AsnGluGlnGlyArgSerThr-392 398-AlaLeuAspGlyPheArgAlaLeuPro-406 419-LysGlyPheAsnHisSer-424 438-LysThrValPheArgProLeuGluGlyLeuSerLeuIleAlaGly-452 465-GlyLysThrLeuHisLysAlaSerLys-473 515-ProArgGluGlyAsnGln-520 565-GlyLysArgValMetGluGlyValGlu-573 617-AlaAsnLeuTrpThrThrTyr-623 635-ValAsnAlaMetSerGlyIleThrSerSer-644 650-GlyGlyTyrAlaThrPheAspAlaMetAlaAla-660 Antigenic Index - Jameson-Wolf 29-GlnThrGluGlyLeuGlu-34 37-HisIleLysGlyGlnArgSer TyrAsn-45 48-AlaThrGluLysAsnGlyAspTyrSerSer-57 68-AlaSerLeuArgGluIleProGln-75 83-GlnGlnValLysAspArgAsnValAspThrPheAspGlnLeuAlaArgLysThrProGlyLeuArgValLeuS erAsnAspAspGlyArgSer-113 118-ArgGlyTyrGluTyrSerGluTyrAsnIleAspGlyLeu-130 148-AspArgValGluValMetArgGlyProSerGlyLeuPheAspSerSerGlyGluMetGlyGly-168 173-ValArgLysArgProThrLysAlaPhe-181 190-GlyThrHisLysGlnTyrLysAlaGluAlaAspValSerGlySerLeuAsnSerAspGlySerValArgGly ArgVal-215 221-GlyAlaSerProArgProAlaGluLysAsnAsnArgArgGluThr-235 242-TrpAspIleAsnProAspThrValLeu-250 257-GlnGlnArgArgLeuAlaProTyrAsn-265 268-ProAlaAspAlaAsnAsnLysLeuProSerLeu-278 306-PheGlyAsnGlyGlyTyrGly-312 314-ValGlyMetArgTyrSerAspArgLysAlaAspSerAsnTyr-327 330-AlaGlySerLysLeuAsnAsnThrGlyGlnAlaAsp-341 346-GlyThrAspIleLysGlnLysAlaPheAlaValAspAlaSerTyrSerArgProPhe-364 378-AεpTyrAsnArgLeuArgSerThrAsnGluGlnGlyArgSerThrLeuSerLysSerValAla-398 413-AsnAlaArgAlaGlyAsnLysGlyPheAsn-422 424-SerValThrGluGluAsnLeuAspGluThrGlyLeu-435 451-AlaGlyGlyArgValGlyHisHisLysIleGluSerGlyAspGlyLysThrLeuHisLysAlaSerLysThr LysPhe-476 485-AspIleAspGlySerAsnSerLeu-492 501-ThrProGlnThrSerIleGlyThrAspGlyLysLeuLeuLysProArgGluGlyAsnGln-520 524-GlyTyrLysGlySerTyrMetAspAspArgLeuAsnThr-536 542-ArgMetLysAspLysAsnAla-548 551-ProLeuAspSerAsnAsnLysLysThrArgTyr-561 563-AlaLeuGlyLlGluThrGluIle-576 596-GlnIleLysThrAlaSerAsnSerArgAspGluGlyIle-608 614-LysHisSerAlaAsnLeu-619 663-PheThrProLysLeuLysLeu-669 671-IleAsnAlaAspAsnIlePhe-677 685-ValGlySerGluSerThrPheAsnIleProGlySerGluArgSerLeu-700 Hydrophilic Regions - Hopp-Woods 39-LysGlyGlnArgSer-43 48-AlaThrGluLysAsnGlyAsp-54 68-AlaSerLeuArgGluIleProGln-75 84-GlnValLysAspArgAsnValAspThr-92 94-AspGlnLeuAlaArgLysThrProGly-102 106-LeuSerAsnAspAspGlyArgSer-113 148-AspArgValGluValMetArgGlyPro-156 162-SerSerGlyGluMet-166 173-ValArgLysArgProThr ys-179 193-LysGlnTyrLysAlaGluAlaAspVal-201 205-LeuAsnSerAspGlySerValArgGlyArgVal-215 222-AlaSerProArgProAlaGluLysAsnAsnArgArgGluThr-235 242-TrpAspIleAsnPro-246 257-GlnGlnArgArgLeuAla-262 268-ProAlaAspAlaAsnAsnLysLeu-275 314-ValGlyMetArgTyrSerAspArgLysAlaAspSer-325 247-ThrAεpIleLysGlnLysAlaPheAla-355 378-AspTyrAsnArgLeuArgSerThrAsnGluGlnGlyArgSerThrLeuSer-394 414-AlaArgAlaGlyAsnLysGlyPhe-421 425-ValThrGluGluAsnLeuAspGlu-432 454-ArgValGlyHisHisLysIleGluSerGlyAspGlyLysThrLeuHisLysAlaSerLysThrLysPhe-47 6 506-IleGlyThrAspGlyLysLeuLeuLysProArgGluGlyAsnGln-520 528-SerTyrMetAspAspArgLeuAsnThr-536 542-ArgMetLysAspLysAsnAla-548 551-ProLeuAspSerAsnAsnLysLysThrArgTyr-561 563-AlaLeuGlyLysArgValMetGluGlyValGluThrGluIle-576 597-IleLysThrAlaSerAsnSerArgAspGluGly-607 695-GlySerGluArgSerLeu-700 761 AMPHI Regions - AMPHI 51-LysGlyTyrIleAsn-55 70-GluThrProGlnThrIleAspThrLeuAsnIle-80 89-AsnAspLeuSerSerIleLeuGlu-96 125-TyrArgAspGlyValArg-130 137-ArgSerThrAlaAsn-141 143-GluArgValGluIleLeuLysGlyProSer-152 164-ValIleAεnMetValSerLysTyrAlaAsnPheLysGlnSerArgAsnIleGlyAlaValTyrGlySerTrp Ala-188 249-TyrAspAsnValGluArgThrProAspArgSerProThrLysSerVal-264 316-AspPheAspHisPheTyrAla-322 388-IleAsnProTyrAspArg-393 452-SerSerArgGlnTyr-456 475-HisThrLeuTyrAlaSerTyrAsnLysGlyPhe-485 511-TyrThrArgGlnTyrGlu-516 526-AspArgLeuSerThrThr-531 568-LeuSerAlaIleGlyGlnIleIle-575 608-AsnThrSerAsnVal-612 651-LeuProGlyPheAlaArgValAspAlaMet-660 Antigenic Index - Jameson-Wolf 23-AlaAspThrGlnAspAsnGlyGluHis-31 43-GlyGlnSerAspThrSerValLeu-50 54-IleAsnTyrAspGluAlaAlaValThrArgAsnGlyGlnLeuIleLysGluThrProGlnThrIle-75 79-AsnIleGlnLysAsnLysAsnTyrGlyThrAsnAsp-90 97-GlyAsnAlaGlyIle-lOl 103-AlaAlaTyrAspMetArgGlyGluSerIlePhe-113 117-PheGlnAlaAspAlaSerAspIleTyrArgAspGlyValArgGluSerGlyGlnValArgArgSerThrAla AsnIleGluArgValGluIleLeuLysGlyProSerSer-153 157-GlyArgThrAsnGlyGlyGly-163 172-AlaAsnPheLysGlnSerArgAsnIleGly-181 187-TrpAlaAsnArgSerLeuAsnMetAspIle-196 198-GluValLeuAsnLysAsnValAlaIle-206 208-LeuThrGlyGluValGlyArgAlaAsnSerPheArgSerGlyIleAspSerLysAsnVal-227 235-ValLysLeuAspAsnGlyLeuLysTrpThrGlyGlnTyrThrTyrAspAsnValGluArgThrProAspArg SerProThrLysSerValTyrAspArgPheGlyLeuProTyr-272 276-PheAlaHisArgAsnAspPheValLysAspLysLeuGln-288 290-TrpArgSerAspLeuGluTyrAlaPheAsnAspLysTrpArgAlaGlnTrp-306 312-ThrAlaAlaGlnAspPhe-317 322-AlaGlySerGluAsnGlyAsnLeuIleLysArgAsnTyrAlaTrpGlnGlnThrAspAsnLysThrLeuSer -345 366-GlyMetAspTyrSerArgGluHisArgAsnProThrLeu-378 389-AsnProTyrAspArgAlaSerTrpProAlaSerGlyArgLeuGlnPro-404 407-ThrGlnAsnArgHisLysAlaAspSer-415 425-SerAlaThrProAspLeuLysPheValLeuGlyGlyArgTyrAspLysTyrThrPheAsnSerGluAsnLys LeuThrGlySerSerArgGlnTyrSerGlyHisSerPheSerProAsn-464 481-TyrAsnLysGlyPheAlaProTyrGlyGlyArgGlyGly-493 506-AsnAlaAspProGluTyrThrArgGlnTyrGluThrGlyValLysSerSerTrpLeuAspAspArgLeuSer Thr-530 539-ArgPheAsnlleArgTyrArgProAspProLysAsnAsnPro-552 557-ValSerGlyLysHisArgSerArgGlyValGlu-567 575-IleProLysLysLeuTyrLeu-581 591-LysValValGluAspLysGluAsnProAspArgValGly-603 607-AsnAsnThrSerAsnVal-612 619-ArgTyrThrProThrGluAsnLeuTyr-627 634-GlyThrGlyLysArgTyrGlyTyrAsnSerArgAsnLysGluValThrThr-650 663-TrpAsnHisLysAsn-667 678-LeuAsnGlnLysTyrTrpArgSerAspSerMetProGlyAsnProArgGlyTyrThrAla-697 Hydrophilic Regions - Hopp-Woods 24-AspThrGlnAspAsnGlyGlu-30 43-GlyGlnSerAspThrSerVal-49 57-AspGluAlaAlaValThrArg-63 66-GlnLeuIleLysGluThrProGlnThr-74 81-GlnLysAsnLysAsnTyrGly-87 105-TyrAspMetArgGlyGluSerIlePhe-113 117-PheGlnAlaAspAlaSerAspIleTyrArgAspGlyValArgGluSerGlyGlnValArgArgSerThrAla AsnIleGluArgValGluIleLeuLysGlyProSer-152 175-LysGlnSerArgAsn-179 208-LeuThrGlyGluValGlyArg-214 220-SerGlyIleAspSerLysAsn-226 235-ValLysLeuAspAsn-239 251-AsnValGluArgThrProAspArgSerProThr-261 278-HisArgAsnAspPheValLysAspLysLeuGln-288 312-ThrAlaAlaGlnAspPhe-317 324-SerGluAsnGlyAsnLeuIleLys-331 339-ThrAspAsnLysThrLeu-344 368-AspTyrSerArgGluHisArgAsnPro-376 390-ProTyrAspArgAlaSer-395 409-AsnArgHisLysAlaAspSer-415 436-GlyArgTyrAspLys-440 445-SerGluAsnLysLeuThrGlySerSerArgGlnTyrSer-457 507-AlaAspProGluTyrThrArgGlnTyrGluThrGlyVal-519 523 -TrpLeuAspAspArgLeuSer-529 544-TyrArgProAspProLysAsn-550 559-GlyLysHisArgSerArgGlyValGlu-567 591-LysValValGluAspLysGluAsnProAspArgValGly-603 634-GlyThrGlyLysArgTyrGlyTyr-641 643-SerArgAsnLysGluValThr-649 686-AspSerMetProGlyAsnProArgGlyTyrThr-696 762 AMPHI Regions - AMPHI 1-MetLysTrpLeuLeuAsnMetIleMetArgProIleLysPheSerMetValAsnThrLeuLeuPheIleValIl eCysSerSerPhePheAspLeuLeuValGlnLeuCysThrlleLeuPheHisSerGlnLysIleTyrPhelleThr LeuPheLeuLeuPhellePheAsnPheValThrLysSerlleTyrMetAlallelleTyrProIleLeuTyrPheP heThrlleLysLysTyrTyrProTyrSerArgLysValllelleLeuLeuSerLeuAlaLeuSerlleTyrPheSe rPheMetAspPheTyrPhePheSerlleTyrSerAspAsnLeuSerTyrGluThrGluProLeuHisLeuTyrlle ProIleIleIleAsnPhePheSerLeuLeuValSerAsnPheIleLeuSerPheIleAsnLys-147 Antigenic Index - Jameson-Wolf 1-MetLysTrpLeuLeuAsnMetIleMetArgProIleLysPheSerMetValAsnThrLeuLeuPheIleValIl eCysSerSerPhePheAspLeuLeuValGlnLeuCysThrlleLeuPheHisSerGlnLysIleTyrPhelleThr LeuPheLeuLeuPhellePheAsnPheValThrLysSerlleTyrMetAlallelleTyrProIleLeuTyrPheP heThrlleLysLysTyrTyrProTyrSerArgLysValllelleLeuLeuSerLeuAlaLeuSerlleTyrPheSe rPheMetAspPheTyrPhePheSerlleTyrSerAspAsnLeuSerTyrGluThrGluProLeuHisLeuTyrlle ProIleIleIleAsnPhePheSerLeuLeuValSerAsnPheIleLeuSerPheIleAsnLys-147 Hydrophilic Regions - Hopp-Woods 1-MetLysTrpLeuLeuAsnMetIleMetArgProIleLysPheSerMetValAsnThrLeuLeuPheIleValIl eCysSerSerPhePheAspLeuLeuValGlnLeuCysThrlleLeuPheHisSerGlnLysIleTyrPhelleThr LeuPheLeuLeuPhellePheAsnPheValThrLysSerlleTyrMetAlallelleTyrProIleLeuTyrPheP heThrlleLysLysTyrTyrProTyrSerArgLysValllelleLeuLeuSerLeuAlaLeuSerlleTyrPheSe rPheMetAspPheTyrPhePheSerlleTyrSerAspAsnLeuSerTyrGluThrGluProLeuHisLeuTyrlle ProIleIleIleAsnPhePheSerLeuLeuValSerAsnPheIleLeuSerPheIleAsnLys-147 763 AMPHI Regions - AMPHI 1-MetThrLeuLeuAsnLeuMetIleMetGlnAspTyrGlyIleSerValCysLeuThrLeuThrProTyrLeuGl nHisGluLeuPheSerAlaMetLysSerTyrPheSerLysTyrlleLeuProValSerLeuPheThrLeuProLeu SerLeuSerProSerValSerAlaPheThrLeuProGluAlaTrpArgAlaAlaGlnGlnHisSerAlaAspPheG InAlaSerHisTyrGlnArgAspAlaValArgAlaArgGlnGlnGlnAlaLysAlaAlaPheLeuProHisValSe rAlaAsnAlaSerTyrGlnArgGlnProProSerlleSerSerThrArgGluThrGlnGlyTrpSerValGlnVal GlyGlnThrLeuPheAspAlaAlaLysPheAlaGlnTyrArgGlnSerArgPheAspThrGlnAlaAlaGluGlnA rgPheAspAlaAlaArgGluGluLeuLeuLeuLysValAlaGluSerTyrPheAsnValLeuLeuSerArgAspTh rValAlaAlaHisAlaAlaGluLysGluAlaTyrAlaGlnGlnValArgGlnAlaGlnAlaLeuPheAsnLysGly AlaAlaThrAlaLeuAspIleHisGluAlaLysAlaGlyTyrAspAsnAlaLeuAlaGlnGluIleAlaValLeuA laGluLysGlnThrTyrGluAsnGlnLeuAsnAspTyrThrAspLeuAspSerLysGlnlleGluAlalleAspTh rAlaAsnLeuLeuAlaArgTyrLeuProLysLeuGluArgTyrSerLeuAspGluTrpGlnArglleAlaLeuSer AsnAsnHisGluTyrArgMetGlnGlnLeuAlaLeuGlnSerSerGlyGlnAlaLeuArgAlaAlaGlnAsnSerA rgTyrProThrValSerAlaHisValGlyTyrGlnAsnAsnLeuTyrThrSerSerAlaGlnAsnAsnAspTyrHi sTyrArgGlyLysGlyMetSerValGlyValGlnLeuAsnLeuProLeuTyrThrGlyGlyGluLeuSerGlyLys IleHisGluAlaGluAlaGlnTyrGlyAlaAlaGluAlaGlnLeuThrAlaThrGluArgHisIleLysLeuAlaV alArgGlnAlaTyrThrGluSerGlyAlaAlaArgTyrGlnlleMetAlaGlnGluArgValLeuGluSerSerAr gLeuLysLeuLysSerThrGluThrGlyGlnGlnTyrGlylleArgAsnArgLeuGluVallleArgAlaArgGln GluValAlaGlnAlaGluGlnLysLeuAlaGlnAlaArgTyrLysPheMetLeuAlaTyrLeuArgLeuValLysG luSerGlyLeuGlyLeuGluThrValPheAlaGlu-467 Antigenic Index - Jameson-Wolf 1-MetThrLeuLeuAsnLeuMetIleMetGlnAspTyrGlyIleSerValCysLeuThrLeuThrProTyrLeuGl nHisGluLeuPheSerAlaMetLysSerTyrPheSerLysTyrlleLeuProValSerLeuPheThrLeuProLeu SerLeuSerProSerValSerAlaPheThrLeuProGluAlaTrpArgAlaAlaGlnGlnHisSerAlaAspPheG lnAlaSerHisTyrGlnArgAspAlaValArgAlaArgGlnGlnGlnAlaLysAlaAlaPheLeuProHisValSe rAlaAsnAlaSerTyrGlnArgGlnProProSerlleSerSerThrArgGluThrGlnGlyTrpSerValGlnVal GlyGlnThrLeuPheAspAlaAlaLysPheAlaGlnTyrArgGlnSerArgPheAspThrGlnAlaAlaGluGlnA rgPheAspAlaAlaArgGluGluLeuLeuLeuLysValAlaGluSerTyrPheAsnValLeuLeuSerArgAspTh rValAlaAlaHisAlaAlaGluLysGluAlaTyrAlaGlnGlnValArgGlnAlaGlnAlaLeuPheAsnLysGly AlaAlaThrAlaLeuAspIleHisGluAlaLysAlaGlyTyrAspAsnAlaLeuAlaGlnGluIleAlaValLeuA laGluLysGlnThrTyrGluAsnGlnLeuAsnAspTyrThrAspLeuAspSerLysGlnlleGluAlalleAspTh rAlaAsnLeuLeuAlaArgTyrLeuProLysLeuGluArgTyrSerLeuAspGluTrpGlnArglleAlaLeuSer AsnAsnHisGluTyrArgMetGlnGlnLeuAlaLeuGlnSerSerGlyGlnAlaLeuArgAlaAlaGlnAsnSerA rgTyrProThrValSerAlaHisValGlyTyrGlnAsnAsnLeuTyrThrSerSerAlaGlnAsnAsnAspTyrHi sTyrArgGlyLysGlyMetSerValGlyValGlnLeuAsnLeuProLeuTyrThrGlyGlyGluLeuSerGlyLys IleHisGluAlaGluAlaGlnTyrGlyAlaAlaGluAlaGlnLeuThrAlaThrGluArgHisIleLysLeuAlaV alArgGlnAlaTyrThrGluSerGlyAlaAlaArgTyrGlnlleMetAlaGlnGluArgValLeuGluSerSerAr gLeuLysLeuLysSerThrGluThrGlyGlnGlnTyrGlylleArgAsnArgLeuGluVallleArgAlaArgGln GluValAlaGlnAlaGluGlnLysLeuAlaGlnAlaArgTyrLysPheMetLeuAlaTyrLeuArgLeuValLysG luSerGlyLeuGlyLeuGluThrValPheAlaGlu-467 Hydrophilic Regions - Hopp-Woods 1-MetThrLeuLeuAsnLeuMetIleMetGlnAspTyrGlyIleSerValCysLeuThrLeuThrProTyrLeuGl nHisGluLeuPheSerAlaMetLysSerTyrPheSerLysTyrlleLeuProValSerLeuPheThrLeuProLeu SerLeuSerProSerValSerAlaPheThrLeuProGluAlaTrpArgAlaAlaGlnGlnHisSerAlaAspPheG InAlaSerHisTyrGlnArgAspAlaValArgAlaArgGlnGlnGlnAlaLysAlaAlaPheLeuProHisValSe rAlaAsnAlaSerTyrGlnArgGlnProProSerlleSerSerThrArgGluThrGlnGlyTrpSerValGlnVal GlyGlnThrLeuPheAspAlaAlaLysPheAlaGlnTyrArgGlnSerArgPheAspThrGlnAlaAlaGluGlnA rgPheAspAlaAlaArgGluGluLeuLeuLeuLysValAlaGluSerTyrPheAsnValLeuLeuSerArgAspTh rValAlaAlaHisAlaAlaGluLysGluAlaTyrAlaGlnGlnValArgGlnAlaGlnAlaLeuPheAsnLysGly AlaAlaThrAlaLeuAspIleHisGluAlaLysAlaGlyTyrAspAsnAlaLeuAlaGlnGluIleAlaValLeuA laGluLysGlnThrTyrGluAsnGlnLeuAsnAspTyrThrAspLeuAspSerLysGlnlleGluAlalleAspTh rAlaAsnLeuLeuAlaArgTyrLeuProLysLeuGluArgTyrSerLeuAspGluTrpGlnArglleAlaLeuSer AsnAsnHisGluTyrArgMetGlnGlnLeuAlaLeuGlnSerSerGlyGlnAlaLeuArgAlaAlaGlnAsnSerA rgTyrProThrValSerAlaHisValGlyTyrGlnAsnAsnLeuTyrThrSerSerAlaGlnAsnAsnAspTyrHi sTyrArgGlyLysGlyMetSerValGlyValGlnLeuAsnLeuProLeuTyrThrGlyGlyGluLeuSerGlyLys IleHisGluAlaGluAlaGlnTyrGlyAlaAlaGluAlaGlnLeuThrAlaThrGluArgHisIleLysLeuAlaV alArgGlnAlaTyrThrGluSerGlyAlaAlaArgTyrGlnlleMetAlaGlnGluArgValLeuGluSerSerAr gLeuLysLeuLysSerThrGluThrGlyGlnGlnTyrGlylleArgAsnArgLeuGluVallleArgAlaArgGln GluValAlaGlnAlaGluGlnLysLeuAlaGlnAlaArgTyrLysPheMetLeuAlaTyrLeuArgLeuValLysG luSerGlyLeuGlyLeuGluThrValPheAlaGlu-467 764 AMPHI Regions - AMPHI 1-MetPhePheSerAlaLeuLysSerPheLeuSerArgTyrIleThrValTrpArgAsnValTrpAlaValArgAs pGlnLeuLysProProLysArgThrAlaGluGluGlnAlaPheLeuProAlaHisLeuGluLeuThrAspThrPro ValSerAlaAlaProLysTrpAlaAlaArgPhelleMetAlaPheAlaLeuLeuAlaLeuLeuTrpSerTrpPheG lyLysIleAspIleValAlaAlaAlaSerGlyLysThrValSerGlyGlyArgSerLysThrlleGlnProLeuGl uThrAlaValValLysAlaValHisValArgAspGlyGlnHisValLysGlnGlyGluThrLeuAlaGluLeuGlu AlaValGlyThrAspSerAspValValGlnSerGluGlnAlaLeuGlnAlaAlaGlnLeuSerLysLeuArgTyrG luAlaValLeuAlaAlaLeuGluSerArgThrValProHisIleAspMetAlaGlnAlaArgSerLeuGlyLeuSe rAspAlaAspValGlnSerAlaGlnValLeuAlaGlnHisGlnTyrGlnAlaTrpAlaAlaGlnAspAlaGlnLeu GlnSerAlaLeuArgGlyHisGlnAlaGluLeuGlnSerAlaLysAlaGlnGluGlnLysLeuValSerValGlyA lalleGluGlnGlnLysThrAlaAspTyrArgArgLeuArgAlaAspAsnPhelleSerGluHisAlaPheLeuGl uGlnGlnSerLysSerValSerAsnTrpAsnAspLeuGluSerThrArgGlyGlnMetArgGlnlleGlnAlaAla IleAlaGlnAlaGluGlnAsnArgValLeuAsnThrGlnAsnLeuLysArgAspThrLeuAspAlaLeuArgGlnA laAsnGluGlnlleAspGlnTyrArgGlyGlnThrAspLysAlaLysGlnArgGlnGlnLeuMetThrlleGlnSe rProAlaAspGlyThrValGlnGluLeuAlaThrTyrThrValGlyGlyValValGlnAlaAlaGlnLysMetMet VallleAlaProAspAspAspLysMetAspValGluValLeuValLeuAsnLysAspIleGlyPheValGluGlnG lyGlnAspAlaValValLysIleGluSerPheProTyrThrArgTyrGlyTyrLeuThrGlyLysValLysSerVa lSerHisAspAlaValSerHisGluGlnLeuGlyLeuValTyrThrAlaValValSerLeuAspLysHisThrLeu AsnlleAspGlyLysAlaValAsnLeuThrAlaGlyMetAsnValThrAlaGluIleLysThrGlyLysArgArgV alLeuAspTyrLeuLeuSerProLeuGlnThrLysLeuAspGluSerPheArgGluArg-475 Antigenic Index - Jameson-Wolf 1-MetPhePheSerAlaLeuLysSerPheLeuSerArgTyrIleThrValTrpArgAsnValTrpAlaValArgAs pGlnLeuLysProProLysArgThrAlaGluGluGlnAlaPheLeuProAlaHisLeuGluLeuThrAspThrPro ValSerAlaAlaProLysTrpAlaAlaArgPhelleMetAlaPheAlaLeuLeuAlaLeuLeuTrpSerTrpPheG lyLysIleAspIleValAlaAlaAlaSerGlyLysThrValSerGlyGlyArgSerLysThrlleGlnProLeuGl uThrAlaValValLysAlaValHisValArgAspGlyGlnHisValLysGlnGlyGluThrLeuAlaGluLeuGlu AlaValGlyThrAspSerAspValValGlnSerGluGlnAlaLeuGlnAlaAlaGlnLeuSerLysLeuArgTyrG luAlaValLeuAlaAlaLeuGluSerArgThrValProHisIleAspMetAlaGlnAlaArgSerLeuGlyLeuSe rAspAlaAspValGlnSerAlaGlnValLeuAlaGlnHisGlnTyrGlnAlaTrpAlaAlaGlnAspAlaGlnLeu GlnSerAlaLeuArgGlyHisGlnAlaGluLeuGlnSerAlaLysAlaGlnGluGlnLysLeuValSerValGlyA lalleGluGlnGlnLysThrAlaAspTyrArgArgLeuArgAlaAspAsnPhelleSerGluHisAlaPheLeuGl uGlnGlnSerLysSerValSerAsnTrpAsnAspLeuGluSerThrArgGlyGlnMetArgGlnlleGlnAlaAla IleAlaGlnAlaGluGlnAsnArgValLeuAsnThrGlnAsnLeuLysArgAspThrLeuAspAlaLeuArgGlnA laAsnGluGlnlleAspGlnTyrArgGlyGlnThrAspLysAlaLysGlnArgGlnGlnLeuMetThrlleGlnSe rProAlaAspGlyThrValGlnGluLeuAlaThrTyrThrValGlyGlyValValGlnAlaAlaGlnLysMetMet VallleAlaProAspAspAspLysMetAspValGluValLeuValLeuAsnLysAspIleGlyPheValGluGlnG lyGlnAspAlaValValLysIleGluSerPheProTyrThrArgTyrGlyTyrLeuThrGlyLysValLysSerVa lSerHisAspAlaValSerHisGluGlnLeuGlyLeuValTyrThrAlaValValSerLeuAspLysHisThrLeu AsnlleAspGlyLysAlaValAsnLeuThrAlaGlyMetAsnValThrAlaGluIleLysThrGlyLysArgArgV alLeuAspTyrLeuLeuSerProLeuGlnThrLysLeuAspGluSerPheArgGluArg-475 Hydrophilic Regions - Hopp-Woods 1-MetPhePheSerAlaLeuLysSerPheLeuSerArgTyrIleThrValTrpArgAsnValTrpAlaValArgAs pGlnLeuLysProProLysArgThrAlaGluGluGlnAlaPheLeuProAlaHisLeuGluLeuThrAspThrPro ValSerAlaAlaProLysTrpAlaAlaArgPhelleMetAlaPheAlaLeuLeuAlaLeuLeuTrpSerTrpPheG lyLysIleAspIleValAlaAlaAlaSerGlyLysThrValSerGlyGlyArgSerLysThrlleGlnProLeuGl uThrAlaValValLysAlaValHisValArgAspGlyGlnHisValLysGlnGlyGluThrLeuAlaGluLeuGlu AlaValGlyThrAspSerAspValValGlnSerGluGlnAlaLeuGlnAlaAlaGlnLeuSerLysLeuArgTyrG luAlaValLeuAlaAlaLeuGluSerArgThrValProHisIleAspMetAlaGlnAlaArgSerLeuGlyLeuSe rAspAlaAspValGlnSerAlaGlnValLeuAlaGlnHisGlnTyrGlnAlaTrpAlaAlaGlnAspAlaGlnLeu GlnSerAlaLeuArgGlyHisGlnAlaGluLeuGlnSerAlaLysAlaGlnGluGlnLysLeuValSerValGlyA lalleGluGlnGlnLysThrAlaAspTyrArgArgLeuArgAlaAspAsnPhelleSerGluHisAlaPheLeuGl uGlnGlnSerLysSerValSerAsnTrpAsnAspLeuGluSerThrArgGlyGlnMetArgGlnlleGlnAlaAla IleAlaGlnAlaGluGlnAsnArgValLeuAsnThrGlnAsnLeuLysArgAspThrLeuAspAlaLeuArgGlnA laAsnGluGlnlleAspGlnTyrArgGlyGlnThrAspLysAlaLysGlnArgGlnGlnLeuMetThrlleGlnSe rProAlaAspGlyThrValGlnGluLeuAlaThrTyrThrValGlyGlyValValGlnAlaAlaGlnLysMetMet VallleAlaProAspAspAspLysMetAspValGluValLeuValLeuAsnLysAspIleGlyPheValGluGlnG lyGlnAspAlaValValLysIleGluSerPheProTyrThrArgTyrGlyTyrLeuThrGlyLysValLysSerVa lSerHisAspAlaValSerHisGluGlnLeuGlyLeuValTyrThrAlaValValSerLeuAspLysHisThrLeu AsnlleAspGlyLysAlaValAsnLeuThrAlaGlyMetAsnValThrAlaGluIleLysThrGlyLysArgArgV alLeuAspTyrLeuLeuSerProLeuGlnThrLysLeuAspGluSerPheArgGluArg-475 765 AMPHI Regions - AMPHI 36-SerAlaIleSerSerPheCys-42 45-LysIleIleHisThrTyr-50 59-ValIleGlyIleIleAsnGly-65 105-ArgPheLeuAsnArgGly-110 147-PheGlyLeuCysTyrPro-152 Antigenic Index - Jameson-Wolf 10-GlyAsnPheLysLysIleAlaThr-17 19-GlnGlyLeuAspArgLysTyr-25 76-ValLysAsnLysGlnLysPheLeu-83 106-PheLeuAsnArgGlyMetLys-112 132-LeuAsnGluGluGlyGlyTrpMet-139 160-LeuSerArgAspTyrLysHisIle-167 Hydrophilic Regions - Hopp-Woods ll-AsnPheLysLysIleAlaThr-17 19-GlnGlyLeuAspArgLys-24 76-ValLysAsnLysGlnLysPheLeu-83 133-AsnGluGluGlyGly-137 162-ArgAspTyrLysHis-166 767 AMPHI Regions - AMPHI 1-MetLysLeuLysHisLeuLeuProLeuLeuLeuSerAlaValLeuSerAlaGlnAlaTyrAlaLeuThrGluGl yGluAspTyrLeuValLeuAspLysProIleProGlnGluGlnSerGlyLysIleGluValLeuGluPhePheGly TyrPheCysValHisCysHisHisPheAspProLeuLeuLeuLysLeuGlyLysAlaLeuProSerAspAlaTyrL euArgThrGluHisValValTrpGlnProGluMetLeuGlyLeuAlaArgMetAlaAlaAlaValAsnLeuSerGl yLeuLysTyrGlnAlaAsnProAlaValPheLysAlaValTyrGluGlnLysIleArgLeuGluAsnArgSerVal AlaGlyLysTrpAlaLeuSerGlnLysGlyPheAspGlyLysLysLeuMetArgAlaTyrAspSerProGluAlaA laAlaAlaAlaLeuLysMetGlnLysLeuThrGluGlnTyrArglleAspSerThrProThrVallleValGlyGl yLysTyrArgValllePheAsnAsnGlyPheAspGlyGlyValHisThrlleLysGluLeuValAlaLysValArg GluGluArgLysArgGlnThrProAlaValGlnLys-214 Antigenic Index - Jameson-Wolf 1-MetLysLeuLysHisLeuLeuProLeuLeuLeuSerAlaValLeuSerAlaGlnAlaTyrAlaLeuThrGluGl yGluAspTyrLeuValLeuAspLysProIleProGlnGluGlnSerGlyLysIleGluValLeuGluPhePheGly TyrPheCysValHisCysHisHisPheAspProLeuLeuLeuLysLeuGlyLysAlaLeuProSerAspAlaTyrL euArgThrGluHisValValTrpGlnProGluMetLeuGlyLeuAlaArgMetAlaAlaAlaValAsnLeuSerGl yLeuLysTyrGlnAlaAsnProAlaValPheLysAlaValTyrGluGlnLysIleArgLeuGluAsnArgSerVal AlaGlyLysTrpAlaLeuSerGlnLysGlyPheAspGlyLysLysLeuMetArgAlaTyrAspSerProGluAlaA laAlaAlaAlaLeuLysMetGlnLysLeuThrGluGlnTyrArglleAspSerThrProThrVallleValGlyGl yLysTyrArgValllePheAsnAsnGlyPheAspGlyGlyValHisThrlleLysGluLeuValAlaLysValArg GluGluArgLysArgGlnThrProAlaValGlnLys-214 Hydrophilic Regions - Hopp-Woods 1-MetLysLeuLysHisLeuLeuProLeuLeuLeuSerAlaValLeuSerAlaGlnAlaTyrAlaLeuThrGluGl yGluAspTyrLeuValLeuAspLysProIleProGlnGluGlnSerGlyLysIleGluValLeuGluPhePheGly TyrPheCysValHisCysHisHisPheAspProLeuLeuLeuLysLeuGlyLysAlaLeuProSerAspAlaTyrL euArgThrGluHisValValTrpGlnProGluMetLeuGlyLeuAlaArgMetAlaAlaAlaValAsnLeuSerGl yLeuLysTyrGlnAlaAsnProAlaValPheLysAlaValTyrGluGlnLysIleArgLeuGluAsnArgSerVal AlaGlyLysTrpAlaLeuSerGlnLysGlyPheAspGlyLysLysLeuMetArgAlaTyrAspSerProGluAlaA laAlaAlaAlaLeuLysMetGlnLysLeuThrGluGlnTyrArglleAspSerThrProThrVallleValGlyGl yLysTyrArgValllePheAsnAsnGlyPheAspGlyGlyValHisThrlleLysGluLeuValAlaLysValArg GluGluArgLysArgGlnThrProAlaValGlnLys-214 768 AMPHI Regions - AMPHI 23-ProGlnLysProValSerAlaAlaGlnThr-32 60-ProValAspGlnIleValArgArgIleHisGluAlaAla-72 93-LeuGlnGluLeuLysLysAlaGlyTyrThrAsnValAlaAsnHisGly-108 Antigenic Index - Jameson-Wolf 21-AlaAlaProGlnLysProValSer-28 42-ValArgSerGluGlnGluPheSerGluGlyHis-52 63-GlnIleValArgArgIleHisGluAlaAlaProAspLysAspThrPro-78 82-TyrCysArgSerGlyArgArgAlaGluAlaAlaLeuGlnGluLeuLysLysAlaGlyTyr-101 106-AsnHisGlyGlyTyrGluAspLeuLeuLysLysGlyMetLys-119 Hydrophilic Regions - Hopp-Woods 22-AlaProGlnLysProValSer-28 42-ValArgSerGluGlnGluPheSerGlu-50 63-GlnIleValArgArgIleHisGluAlaAlaProAspLysAspThrPro-78 84-ArgSerGlyArgArgAlaGluAlaAlaLeuGlnGluLeuLysLysAlaGly-100 109-GlyTyrGluAspLeuLeuLysLysGlyMetLys-119 769 AMPHI Regions - AMPHI 1-LeuIleMetValIlePheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLeuLeuPr oLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProArgGluProAspLeuArgSerArgProGluPheArgLeu HisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuGlnl leAspGlyGluThrLeuLeuLysAsnProGluLeuLeuSerArgAlaMetTyrSerAlaValValSerAsnAsnll eAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaGlnGlnAspLysMetLeuAlaLeuTyrAlaGln GlylleLeuAlaGlnAlaAspGlyArgValLysGluAlalleSerHisTyrArgGluLeuIleAlaAlaGlnProA spAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAsnArgGlnAsnGluAlaAlaAlaAspGlnPh eAspArgLeuLysAlaGluAsnLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArgGlu ArgAspAlaTrpLysValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysArgGlnG InTyrGlyLysTrpThrPheProLysGlnValAspGlyThrAlaValAsnTyrArgLeuGlyAlaGluLysLysTr pSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLysPhe AsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspAlaGlyLeuAlaValPheH isGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrThrAsnGlyAlaArgLeuTyrPheAsnArgTrpGlnTh rProLysTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAsnThrArgArgAlaArgSerAspAsnThr HisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpMetGlyGlyLeuAspPheTyrA rgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTrpGl yGlySerGlyLeuSerSerLeuLeuArgLeuGlyAlaAlaLysArgHisTyrGluLysProGlyPhePheSerGly PheLysGlyGluArgArgArgAspLysGluLeuAsnThrSerLeuSerLeuTrpHisArgAlaLeuHisPheLysG lylleThrProArgLeuThrLeuSerHisArgGluThrArgSerAsnAspValPheAsnGluTyrGluLysAsnAr gAlaPheValGluPheAsnLysThrPhe-490 Antigenic Index - Jameson-Wolf 1-LeuIleMetValIlePheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLeuLeuPr oLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProArgGluProAspLeuArgSerArgProGluPheArgLeu HisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuGlnl leAspGlyGluThrLeuLeuLysAsnProGluLeuLeuSerArgAlaMetTyrSerAlaValValSerAsnAsnll eAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaGlnGlnAspLysMetLeuAlaLeuTyrAlaGln GlylleLeuAlaGlnAlaAspGlyArgValLysGluAlalleSerHisTyrArgGluLeuIleAlaAlaGlnProA spAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAsnArgGlnAsnGluAlaAlaAlaAspGlnPh eAspArgLeuLysAlaGluAsnLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArgGlu ArgAspAlaTrpLysValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysArgGlnG InTyrGlyLysTrpThrPheProLysGlnValAspGlyThrAlaValAsnTyrArgLeuGlyAlaGluLysLysTr pSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLysPhe AsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspAlaGlyLeuAlaValPheH isGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrThrAsnGlyAlaArgLeuTyrPheAsnArgTrpGlnTh rProLysTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAsnThrArgArgAlaArgSerAspAsnThr HisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpMetGlyGlyLeuAspPheTyrA rgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTrpGl yGlySerGlyLeuSerSerLeuLeuArgLeuGlyAlaAlaLysArgHisTyrGluLysProGlyPhePheSerGly PheLysGlyGluArgArgArgAspLysGluLeuAsnThrSerLeuSerLeuTrpHisArgAlaLeuHisPheLysG lylleThrProArgLeuThrLeuSerHisArgGluThrArgSerAsnAspValPheAsnGluTyrGluLysAsnAr gAlaPheValGluPheAsnLysThrPhe-490 Hydrophilic Regions - Hopp-Woods 1-LeuIleMetValIlePheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLeuLeuPr oLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProArgGluProAspLeuArgSerArgProGluPheArgLeu HisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuGlnl leAspGlyGluThrLeuLeuLysAsnProGluLeuLeuSerArgAlaMetTyrSerAlaValValSerAsnAsnll eAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaGlnGlnAspLysMetLeuAlaLeuTyrAlaGln GlylleLeuAlaGlnAlaAspGlyArgValLysGluAlalleSerHisTyrArgGluLeuIleAlaAlaGlnProA spAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAsnArgGlnAsnGluAlaAlaAlaAspGlnPh eAspArgLeuLysAlaGluAsnLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArgGlu ArgAspAlaTrpLysValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysArgGlnG InTyrGlyLysTrpThrPheProLysGlnValAspGlyThrAlaValAsnTyrArgLeuGlyAlaGluLysLysTr pSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLysPhe AsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspAlaGlyLeuAlaValPheH isGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrThrAsnGlyAlaArgLeuTyrPheAsnArgTrpGlnTh rProLysTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAsnThrArgArgAlaArgSerAspAsnThr HisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpMetGlyGlyLeuAspPheTyrA rgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTrpGl yGlySerGlyLeuSerSerLeuLeuArgLeuGlyAlaAlaLysArgHisTyrGluLysProGlyPhePheSerGly PheLysGlyGluArgArgArgAspLysGluLeuAsnThrSerLeuSerLeuTrpHisArgAlaLeuHisPheLysG lylleThrProArgLeuThrLeuSerHisArgGluThrArgSerAsnAspValPheAsnGluTyrGluLysAsnAr gAlaPheValGluPheAsnLysThrPhe-490 770 AMPHI Regions - AMPHI 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuLeuThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnlleLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaSerValSerCysValGlnThrAlaSerΞerlleSerPheAspGluThrAlaValArgLysProLysGl uValPheLysHisGlyAlaSerPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysThr PheAlaTyrLeuValTyrSerAspLysIlelleGlnGlySerProLysAsnSerLeuSerAlaValΞerCysPheG lyGlyGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyAsnLeuLeuAlaGlyAlaCysMetlleSe rAsnProIleGluAsnLeuAspLysArg-186 Antigenic Index - Jameson-Wolf 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuLeuThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnlleLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaΞerValSerCysValGlnThrAlaSerSerlleSerPheAspGluThrAlaValArgLysProLysGl uValPheLysHisGlyAlaSerPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysThr PheAlaTyrLeuValTyrSerAspLysIlelleGlnGlySerProLysAsnSerLeuSerAlaValSerCysPheG lyGlyGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyAsnLeuLeuAlaGlyAlaCysMetlleSe rAsnProlleGluAsnLeuAspLysArg-186 Hydrophilic Regions - Hopp-Woods 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuLeuThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnlleLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaSerValSerCysValGlnThrAlaSerSerlleSerPheAspGluThrAlaValArgLysProLysGl uValPheLysHisGlyAlaSerPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysThr PheAlaTyrLeuValTyrSerAspLysIlelleGlnGlySerProLysAsnSerLeuSerAlaValSerCysPheG lyGlyGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyAsnLeuLeuAlaGlyAlaCysMetlleSe rAsnProIleGluAsnLeuAspLysArg-186 771 AMPHI Regions - AMPHI 1-MetAspLeuLeuSerValPheHisLysTyrArgLeuLysTyrAlaValAlaValLeuThrIleLeuLeuLeuAl aAlaValGlyLeuHisAlaSerValTyrArgThrPheThrProGluAsnlleArgSerArgLeuGlnGlnSerlie AlaHisThrHisArgLysIleSerPheAspAlaAspIleGlnArgArgLeuLeuProArgProThrVallleLeuL ysAsnLeuThrlleThrGluProGlyGlyAspGlnThrAlaValSerValGlnGluThrLysIleGlyLeuSerTr pLysAsnLeuTrpSerAspGlnlleGlnlleGluLysTrpValValSerSerAlaGluLeuAlaLeuThrArgAsp GlyLysGlyValTrpAsnlleGlnAspLeuIleAspSerGlnLysArgGlnAlaSerValAsnArgllelleValG luAsnSerThrValArgLeuAsnPheLeuGlnGluGlnLeuIleLeuLysGluIleAsnLeuAsnLeuGlnSerPr oAspSerSerGlyGlnProPheGluSerSerGlylleLeuValTrpGlyLysLeuSerValProTrpLysSerArg GlyLeuPheLeuSerAsnGlylleGlyProProGluIleSerProPheHisPheGluAlaSerThrSerLeuAspG lyHisGlylleThrlleSerThrThrGlySerProSerValArgPheAsnAlaGlyGlyAlaAspAlaAlaGlyLe uGlyLeuArgAlaAspThrSerPheArgAsnLeuHisLeuThrAlaGlnlleProAlaLeuAlaLeuArgAsnAsn SerlleLysIleGluThrValAsnGlyAlaPheThrAlaGlyGlyGluTyrAlaArgTrpAspGlySerPheLysL euAspLysAlaAsnLeuHisSerGlylleAlaAsnlleGlyAsnAlaGluIleSerGlySerPheLysThrProAr gHisGlnThrAsnPheSerLeuAsnSerProLeuValTrpThrGluAsnLysGlyLeuAspAlaProArgLeuTyr ValΞerThrLeuGlnAspThrValAsnArgLeuProGlnProArgPhelleSerArgLeuAspGlySerLeuSerV alProAsnLeuGlnAsnTrpAsnAlaGluLeuAsnGlyThrPheAspArgGlnThrValAlaAlaLysPheArgTy rThrHisGluAspAlaProHisLeuGluAlaAlaValAlaLeuGlnLysLeuAsnLeuThrProTyrLeuAspAsp ValArgGlnGlnAsnGlyLysIlePheProAspThrLeuAlaLysLeuSerGlyAspIleGluAlaHisLeuLysI leGlyLysValGlnLeuProGlyLeuGlnLeuAspAspMetGluThrTyrLeuHisAlaAspLysGlyHisIleAl aLeuSerArgPheLysSerGlyLeuTyrGlyGlyHisThrGluGlyGlylleSerlleAlaAsnThrArgProAla ThrTyrArgLeuGlnGlnAsnAlaSerAsnlleGlnlleGlnProLeuLeuGlnAspLeuPheGlyPheHisSerP heSerGlyAsnGlyAspAlaVallleAspLeuThrAlaGlyGlyGluThrArgLysGluLeuIleArgSerLeuGl nGlySerLeuSerLeuAsnlleSerAsnGlyAlaTrpHisGlylleAspMetAspAsnlleLeuLysAsnGlylle SerGlyLysThrAlaAspAsnAlaAlaProSerThrProPheHisArgPheThrLeuAsnSerGluIleSerAspG lylleSerArgHisIleAspThrGluLeuPheSerAspSerLeuTyrValThrSerAsnGlyTyrThrAsnLeuAs pThrGlnGluLeuSerGluAspValLeuIleArgAsnAlaValHisProLysAsnLysProIleProLeuLysIle ThrGlyThrValAspLysProSerlleThrValAspTyrGlyArgLeuThrGlyGlylleAsnSerArgLysGluL ysGlnLysIleLeuGluAspThrLeuLeuGluGlnTrpGlnTrpLeuLysProLysGluProAla-705 Antigenic Index - Jameson-Wolf 1-MetAspLeuLeuSerValPheHisLysTyrArgLeuLysTyrAlaValAlaValLeuThrIleLeuLeuLeuAl aAlaValGlyLeuHisAlaSerValTyrArgThrPheThrProGluAsnlleArgSerArgLeuGlnGlnSerlie AlaHisThrHisArgLysIleSerPheAspAlaAspIleGlnArgArgLeuLeuProArgProThrVallleLeuL ysAsnLeuThrlleThrGluProGlyGlyAspGlnThrAlaValSerValGlnGluThrLysIleGlyLeuSerTr pLysAsnLeuTrpSerAspGlnlleGlnlleGluLysTrpValValSerSerAlaGluLeuAlaLeuThrArgAsp GlyLysGlyValTrpAsnlleGlnAspLeuIleAspSerGlnLysArgGlnAlaSerValAsnArgllelleValG luAsnSerThrValArgLeuAsnPheLeuGlnGluGlnLeuIleLeuLysGluIleAsnLeuAsnLeuGlnSerPr oAspSerSerGlyGlnProPheGluSerΞerGlylleLeuValTrpGlyLysLeuSerValProTrpLysSerArg GlyLeuPheLeuSerAsnGlylleGlyProProGluIleSerProPheHisPheGluAlaSerThrSerLeuAspG lyHisGlylleThrlleSerThrThrGlySerProSerValArgPheAsnAlaGlyGlyAlaAspAlaAlaGlyLe uGlyLeuArgAlaAspThrSerPheArgAsnLeuHisLeuThrAlaGlnlleProAlaLeuAlaLeuArgAsnAsn SerlleLysIleGluThrValAsnGlyAlaPheThrAlaGlyGlyGluTyrAlaArgTrpAspGlySerPheLysL euAspLysAlaAsnLeuHisSerGlylleAlaAsnlleGlyAsnAlaGluIleSerGlySerPheLysThrProAr gHisGlnThrAsnPheSerLeuAsnSerProLeuValTrpThrGluAsnLysGlyLeuAspAlaProArgLeuTyr ValSerThrLeuGlnAspThrValAsnArgLeuProGlnProArgPhelleSerArgLeuAspGlySerLeuSerV alProAsnLeuGlnAsnTrpAsnAlaGluLeuAsnGlyThrPheAspArgGlnThrValAlaAlaLysPheArgTy rThrHisGluAspAlaProHisLeuGluAlaAlaValAlaLeuGlnLysLeuAsnLeuThrProTyrLeuAspAsp ValArgGlnGlnAsnGlyLysIlePheProAspThrLeuAlaLysLeuSerGlyAspIleGluAlaHisLeuLysI leGlyLysValGlnLeuProGlyLeuGlnLeuAspAspMetGluThrTyrLeuHisAlaAspLysGlyHisIleAl aLeuSerArgPheLysSerGlyLeuTyrGlyGlyHisThrGluGlyGlylleSerlleAlaAsnThrArgProAla ThrTyrArgLeuGlnGlnAsnAlaSerAsnlleGlnlleGlnProLeuLeuGlnAspLeuPheGlyPheHisSerP heSerGlyAsnGlyAspAlaVallleAspLeuThrAlaGlyGlyGluThrArgLysGluLeuIleArgSerLeuGl nGlySerLeuSerLeuAsnlleSerAsnGlyAlaTrpHisGlylleAspMetAspAsnlleLeuLysAsnGlylle SerGlyLysThrAlaAspAsnAlaAlaProSerThrProPheHisArgPheThrLeuAsnSerGluIleSerAspG lylleSerArgHisIleAspThrGluLeuPheSerAspSerLeuTyrValThrSerAsnGlyTyrThrAsnLeuAs pThrGlnGluLeuSerGluAspValLeuIleArgAsnAlaValHisProLysAsnLysProIleProLeuLysIle ThrGlyThrValAspLysProSerlleThrValAspTyrGlyArgLeuThrGlyGlylleAsnSerArgLysGluL ysGlnLysIleLeuGluAspThrLeuLeuGluGlnTrpGlnTrpLeuLysProLysGluProAla-705 Hydrophilic Regions - Hopp-Woods 1-MetAspLeuLeuSerValPheHisLysTyrArgLeuLysTyrAlaValAlaValLeuThrIleLeuLeuLeuAl aAlaValGlyLeuHisAlaSerValTyrArgThrPheThrProGluAsnlleArgSerArgLeuGlnGlnSerlle AlaHisThrHisArgLysIleSerPheAspAlaAspIleGlnArgArgLeuLeuProArgProThrVallleLeuL ysAsnLeuThrlleThrGluProGlyGlyAspGlnThrAlaValSerValGlnGluThrLysIleGlyLeuSerTr pLysAsnLeuTrpSerAspGlnlleGlnlleGluLysTrpValValSerSerAlaGluLeuAlaLeuThrArgAsp GlyLysGlyValTrpAsnlleGlnAspLeuIleAspSerGlnLysArgGlnAlaSerValAsnArgllelleValG luAsnSerThrValArgLeuAsnPheLeuGlnGluGlnLeuIleLeuLysGluIleAsnLeuAsnLeuGlnSerPr oAspSerSerGlyGlnProPheGluSerSerGlylleLeuValTrpGlyLysLeuSerValProTrpLysSerArg GlyLeuPheLeuSerAsnGlylleGlyProProGluIleSerProPheHisPheGluAlaSerThrSerLeuAspG lyHisGlylleThrlleSerThrThrGlySerProSerValArgPheAsnAlaGlyGlyAlaAspAlaAlaGlyLe uGlyLeuArgAlaAspThrSerPheArgAsnLeuHisLeuThrAlaGlnlleProAlaLeuAlaLeuArgAsnAsn SerlleLysIleGluThrValAsnGlyAlaPheThrAlaGlyGlyGluTyrAlaArgTrpAspGlySerPheLysL euAspLysAlaAsnLeuHisSerGlylleAlaAsnlleGlyAsnAlaGluIleSerGlySerPheLysThrProAr gHisGlnThrAsnPheSerLeuAsnSerProLeuValTrpThrGluAsnLysGlyLeuAspAlaProArgLeuTyr ValSerThrLeuGlnAspThrValAsnArgLeuProGlnProArgPhelleSerArgLeuAspGlySerLeuSerV alProAsnLeuGlnAsnTrpAsnAlaGluLeuAsnGlyThrPheAspArgGlnThrValAlaAlaLysPheArgTy rThrHisGluAspAlaProHisLeuGluAlaAlaValAlaLeuGlnLysLeuAsnLeuThrProTyrLeuAspAsp ValArgGlnGlnAsnGlyLysIlePheProAspThrLeuAlaLysLeuSerGlyAspIleGluAlaHisLeuLysI leGlyLysValGlnLeuProGlyLeuGlnLeuAspAspMetGluThrTyrLeuHisAlaAspLysGlyHisIleAl aLeuSerArgPheLysSerGlyLeuTyrGlyGlyHisThrGluGlyGlylleSerlleAlaAsnThrArgProAla ThrTyrArgLeuGlnGlnAsnAlaSerAsnlleGlnlleGlnProLeuLeuGlnAspLeuPheGlyPheHisSerP heSerGlyAsnGlyAspAlaVallleAspLeuThrAlaGlyGlyGluThrArgLysGluLeuIleArgSerLeuGl nGlySerLeuSerLeuAsnlleSerAsnGlyAlaTrpHisGlylleAspMetAspAsnlleLeuLysAsnGlylle SerGlyLysThrAlaAspAsnAlaAlaProSerThrProPheHisArgPheThrLeuAsnSerGluIleSerAspG lylleSerArgHisIleAspThrGluLeuPheSerAspSerLeuTyrValThrSerAsnGlyTyrThrAsnLeuAs pThrGlnGluLeuSerGluAspValLeuIleArgAsnAlaValHisProLysAsnLysProIleProLeuLysIle ThrGlyThrValAspLysProSerlleThrValAspTyrGlyArgLeuThrGlyGlylleAsnSerArgLysGluL ysGlnLysIleLeuGluAspThrLeuLeuGluGlnTrpGlnTrpLeuLysProLysGluProAla-705 772 AMPHI Regions - AMPHI 1-MetPheGlyAlaValLeuArgIleAspAlaAspCysLeuGlnIleIleValAlaCysLysLeuPheGlnIleVa lAlaTyrGlyPheAlaAlaLeuValGluGlyGluPheHisGluPheGlyLysMetLeuGluIleValArgLeuAla AspAlaValPheHisArgAsnHisThrAspAspGlyGlylleHisPheArgArgArgValGluArgPheGlyArgT yrValAsnGlnHisPheHisIleGluLysIleLeuGlnHisHisAlaGlnAlaAlaValValValAlaPheArgAr gGlyAsnHisThrLeuAspHisPhePheLeuGlnHisLysValHisIleAspAspIleValArgHisLeuArgGln LeuGluGlnLysArgCysGlyAsnValValArgGluValAlaAspAspPheLeuPheAlaCysAspAlaValGluI leLysLeuGlnTyrlleAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspVa lAlaValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnArgArgGlnThrArgAla AspPheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnL ysIleLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerPheSerValGluThrProProPheAr gAlaValGluSerAspSerIleTrpGluGlyArgAsnSerPheGlnlleArgMetAlaHisArgAlaValLeuTyr ValSerSerCysValLeuLysHisLysCysValTyrΞerIleArgLeuMetSerAlaLeu-298 Antigenic Index - Jameson-Wolf 1-MetPheGlyAlaValLeuArgIleAspAlaAspCysLeuGlnIleIleValAlaCysLysLeuPheGlnIleVa lAlaTyrGlyPheAlaAlaLeuValGluGlyGluPheHisGluPheGlyLysMetLeuGluIleValArgLeuAla AspAlaValPheHisArgAsnHisThrAspAspGlyGlylleHisPheArgArgArgValGluArgPheGlyArgT yrValAsnGlnHisPheHisIleGluLysIleLeuGlnHisHisAlaGlnAlaAlaValValValAlaPheArgAr gGlyAsnHisThrLeuAspHisPhePheLeuGlnHisLysValHisIleAspAspIleValArgHisLeuArgGln LeuGluGlnLysArgCysGlyAsnValValArgGluValAlaAspAspPheLeuPheAlaCysAspAlaValGluI leLysLeuGlnTyrlleAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspVa lAlaValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnArgArgGlnThrArgAla AspPheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnL ysIleLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerPheSerValGluThrProProPheAr gAlaValGluSerAspSerlleTrpGluGlyArgAsnSerPheGlnlleArgMetAlaHisArgAlaValLeuTyr ValSerSerCysValLeuLysHisLysCysValTyrSerIleArgLeuMetSerAlaLeu-298 Hydrophilic Regions - Hopp-Woods 1-MetPheGlyAlaValLeuArgIleAspAlaAspCysLeuGlnIleileValAlaCysLysLeuPheGlnlleVa lAlaTyrGlyPheAlaAlaLeuValGluGlyGluPheHisGluPheGlyLysMetLeuGluIleValArgLeuAla AspAlaValPheHisArgAsnHisThrAspAspGlyGlylleHisPheArgArgArgValGluArgPheGlyArgT yrValAsnGlnHisPheHisIleGluLysIleLeuGlnHisHisAlaGlnAlaAlaValValValAlaPheArgAr gGlyAsnHisThrLeuAspHisPhePheLeuGlnHisLysValHisIleAspAspIleValArgHisLeuArgGln LeuGluGlnLysArgCysGlyAsnValValArgGluValAlaAspAspPheLeuPheAlaCysAspAlaValGluI leLysLeuGlnTyrlleAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspVa lAlaValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnArgArgGlnThrArgAla AspPheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnL ysIleLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerPheSerValGluThrProProPheAr gAlaValGluSerAspSerlleTrpGluGlyArgAsnSerPheGlnlleArgMetAlaHisArgAlaValLeuTyr ValSerSerCysValLeuLysHisLysCysValTyrSerIleArgLeuMetSerAlaLeu-298 773 AMPHI Regions - AMPHI 1-MetGlyLeuGlyAlaThrThrPheValGlySerGlyAlaIleGlyGlyGlyLeuCysSerThrGlyIleGlyCy sAlaAlaGlyGlyLeuIleAlaThrAlaGlyMetThrGlyGlyTyrThrGlnAlaSerGluGlySerArgGlnLeu PheGlyThrTyrGlnSerAspPheGlyLysLysValValLeuSerLeuGlyThrProIleGluTyrGluSerProL euValSerAspAlaLysAsnLeuAlaValTrpGlyLeuGluThrLeuIleThrArgLysLeuGlyAsnLeuAlaTh rGlyValLysThrSerLeuThrProLysThrAlaAspValGlnArgAsnlleLeuSerGlnSerGluValGlylle LysTrpGlyLysGlylleGluGlyGlnGlyMetProTrpGluAspTyrValGlyLysGlyLeuSerAlaAsnAlaA rgLeuProLysAsnPheLysThrPheAspTyrPheAspArgGlyThrGlyThrAlalleSerAlaLysThrLeuAs pThrGlnThrThrAlaArgLeuSerLysProGluGlnLeuTyrSerThrMetLysGlyTyrlleAspLysThrAla AsnPheLysSerTyrGluLeuSerGluValProLeuArgAlaAspMetlleLysGlnArgGluIleHisLeuAlal leProAlaGlnThrAsnLysGluGlnArgLeuGlnLeuGlnArgValValGluTyrGlyLysSerGlnAsnlleTh rValLysIleThrGluIleGlu-260 Antigenic Index - Jameson-Wolf 1-MetGlyLeuGlyAlaThrThrPheValGlySerGlyAlaIleGlyGlyGlyLeuCysSerThrGlyIleGlyCy sAlaAlaGlyGlyLeuIleAlaThrAlaGlyMetThrGlyGlyTyrThrGlnAlaSerGluGlySerArgGlnLeu PheGlyThrTyrGlnSerAspPheGlyLysLysValValLeuSerLeuGlyThrProIleGluTyrGluSerProL euValSerAspAlaLysAsnLeuAlaValTrpGlyLeuGluThrLeuIleThrArgLysLeuGlyAsnLeuAlaTh rGlyValLysThrSerLeuThrProLysThrAlaAspValGlnArgAsnlleLeuSerGlnSerGluValGlylle LysTrpGlyLysGlylleGluGlyGlnGlyMetProTrpGluAspTyrValGlyLysGlyLeuSerAlaAsnAlaA rgLeuProLysAsnPheLysThrPheAspTyrPheAspArgGlyThrGlyThrAlalleSerAlaLysThrLeuAs pThrGlnThrThrAlaArgLeuSerLysProGluGlnLeuTyrSerThrMetLysGlyTyrlleAspLysThrAla AsnPheLysSerTyrGluLeuSerGluValProLeuArgAlaAspMetlleLysGlnArgGluIleHisLeuAlal leProAlaGlnThrAsnLysGluGlnArgLeuGlnLeuGlnArgValValGluTyrGlyLysSerGlnAsnlleTh rValLysIleThrGluIleGlu-260 Hydrophilic Regions - Hopp-Woods 1-MetGlyLeuGlyAlaThrThrPheValGlySerGlyAlaIleGlyGlyGlyLeuCysSerThrGlyIleGlyCy sAlaAlaGlyGlyLeuIleAlaThrAlaGlyMetThrGlyGlyTyrThrGlnAlaSerGluGlySerArgGlnLeu PheGlyThrTyrGlnSerAspPheGlyLysLysValValLeuSerLeuGlyThrProIleGluTyrGluSerProL euValSerAspAlaLysAsnLeuAlaValTrpGlyLeuGluThrLeuIleThrArgLysLeuGlyAsnLeuAlaTh rGlyValLysThrSerLeuThrProLysThrAlaAspValGlnArgAsnlleLeuSerGlnSerGluValGlylle LysTrpGlyLysGlylleGluGlyGlnGlyMetProTrpGluAspTyrValGlyLysGlyLeuSerAlaAsnAlaA rgLeuProLysAsnPheLysThrPheAspTyrPheAspArgGlyThrGlyThrAlalleSerAlaLysThrLeuAs pThrGlnThrThrAlaArgLeuSerLysProGluGlnLeuTyrSerThrMetLysGlyTyrlleAspLysThrAla AsnPheLysSerTyrGluLeuSerGluValProLeuArgAlaAspMetlleLysGlnArgGluIleHisLeuAlal leProAlaGlnThrAsnLysGluGlnArgLeuGlnLeuGlnArgValValGluTyrGlyLysSerGlnAsnlleTh rValLysIleThrGluIleGlu-260 774 AMPHI Regions - AMPHI 1-MetLysIleLysLeuProLeuPheIleIleTrpLeuSerValSerAlaSerCysAlaSerValSerProValPr oAlaGlySerGlnThrGluMetSerThrArgGluAsnAlaSerAspGlylleProTyrProValProThrLeuGln AspArgLeuAspTyrLeuGluGlyLysIleValArgLeuSerAsnGluValGluThrLeuAsnGlyLysValLysA laLeuGluHisAlaLysThrHisSerSerGlyArgAlaTyrValGlnLysLeuAspAspArgLysLeuLysGluHi sTyrLeuAsnThrGluGlyGlySerAlaSerAlaHisThrValGluThrAlaGlnAsnLeuTyrAsnGlnAlaLeu LysHisTyrLysSerGlyLysPheSerAlaAlaAlaSerLeuLeuLysGlyAlaAspGlyGlyAspGlyGlySerl leAlaGlnArgSerMetTyrLeuLeuLeuGlnSerArgAlaArgMetGlyAsnCysGluSerVallleGluIleGl yGlyArgTyrAlaAsnArgPheLysAspSerProThrAlaProGluAlaMetPheLysIleGlyGluCysGlnTyr ArgLeuGlnGlnLysAspIleAlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGlySerProAlaAlaL ysArgAlaAlaAlaAlaValArgLysArg-237 Antigenic Index - Jameson-Wolf 1-MetLysIleLysLeuProLeuPheIleIleTrpLeuSerValSerAlaSerCysAlaSerValSerProValPr oAlaGlySerGlnThrGluMetSerThrArgGluAsnAlaSerAspGlylleProTyrProValProThrLeuGln AspArgLeuAspTyrLeuGluGlyLysIleValArgLeuSerAsnGluValGluThrLeuAsnGlyLysValLysA laLeuGluHisAlaLysThrHisSerSerGlyArgAlaTyrValGlnLysLeuAspAspArgLysLeuLysGluHi sTyrLeuAsnThrGluGlyGlySerAlaSerAlaHisThrValGluThrAlaGlnAsnLeuTyrAsnGlnAlaLeu LysHisTyrLysSerGlyLysPheSerAlaAlaAlaSerLeuLeuLysGlyAlaAspGlyGlyAspGlyGlySerl leAlaGlnArgSerMetTyrLeuLeuLeuGlnSerArgAlaArgMetGlyAsnCysGluSerVallleGluIleGl yGlyArgTyrAlaAsnArgPheLysAspSerProThrAlaProGluAlaMetPheLysIleGlyGluCysGlnTyr ArgLeuGlnGlnLysAspIleAlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGlySerProAlaAlaL ysArgAlaAlaAlaAlaValArgLysArg-237 Hydrophilic Regions - Hopp-Woods 1-MetLysIleLysLeuProLeuPheIleIleTrpLeuSerValSerAlaSerCysAlaSerValSerProValPr oAlaGlySerGlnThrGluMetSerThrArgGluAsnAlaSerAspGlylleProTyrProValProThrLeuGln AspArgLeuAspTyrLeuGluGlyLysIleValArgLeuSerAsnGluValGluThrLeuAsnGlyLysValLysA laLeuGluHisAlaLysThrHisSerSerGlyArgAlaTyrValGlnLysLeuAspAspArgLysLeuLysGluHi sTyrLeuAsnThrGluGlyGlySerAlaSerAlaHisThrValGluThrAlaGlnAsnLeuTyrAsnGlnAlaLeu LysHisTyrLysSerGlyLysPheSerAlaAlaAlaSerLeuLeuLysGlyAlaAspGlyGlyAspGlyGlySerl leAlaGlnArgSerMetTyrLeuLeuLeuGlnSerArgAlaArgMetGlyAsnCysGluSerVallleGluIleGl yGlyArgTyrAlaAsnArgPheLysAspSerProThrAlaProGluAlaMetPheLysIleGlyGluCysGlnTyr ArgLeuGlnGlnLysAspIleAlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGlySerProAlaAlaL ysArgAlaAlaAlaAlaValArgLysArg-237 790 AMPHI Regions - AMPHI 10-GluAlaAlaAlaGluVal-15 44-GlyAsnGlnThrCysSerArgTyrSerAsn-53 89-LysGlnAlaValThr-93 103-ThrGlnAlaTyrAsnGluMetThrLysSerVal-113 166-PheAlaArgThrGlyLysLeu-172 174-GlySerPheAspLeuPheAlaSerVal-182 253-ProSerGluAlaPheAspLeuProGluGlySerThr-264 320-PheLeuArgPheTrpGlnAlaThrArgGly11e-330 Antigenic Index - Jameson-Wolf 1-MetAlaArgArgSerLysThrPheGluGluAlaAlaAlaGluValGluGluArgPheGlyHisArgGlyIleLy s-25 30-GluGlyThrAlaLysProCysVal-37 39-AsnCysProLysHisGlyAsnGlnThrCysSerArgTyrSer-52 57-GlySerSerTrpGlyCysProSerCysGlyAsnGluGlnAlaAla-71 77-ThrLeuArgLysAsnHisIle-83 95-MetThrLysGlnGluArgIleThr-102 123-AspValGlnGlyAspThrThrIle-130 134-HisThrHisThrHisAsnHisSerAspAlaAspGlyLysAlaLeuSer-149 152-LeuThrProArgProLeuLeuSerAspArgGlnAla-163 167-AlaArgThrGlyLysLeuThrGly-174 194-MetProAspThrSerMet-199 201-ProValIleGluLysGlyAsp-207 213-ProArgMetCysProAlaAspGluAspIleAla-223 226-GluLeuSerAspLysArgLeuVal-233 248-TyrGlnThrGlyArgProSerGluAlaPheAspLeuProGluGlySerThr-264 270-LeuGluSerLysAsnGlyLeuCysProProHisArgGlnGluGlyVal-285 301-SerAlaSerLysThrSerCysThrArgProThrAlaAlaArgLysSerAla-317 326-AlaThrArgGlyIleProLysThrArgSerTrpArgAsnProAsnAsnAla-342 Hydrophilic Regions - Hopp-Woods 1-MetAlaArgArgSerLysThrPheGluGluAlaAlaAlaGluValGluGluArgPheGlyHisArgGlyIleLy s-25 65-CysGlyAsnGluGlnAlaAla-71 77-ThrLeuArgLysAsnHisIle-83 96-ThrLysGlnGluArgIleThr-102 139-AsnHisSerAspAlaAspGlyLysAlaLeuSer-149 157-LeuLeuSerAspArgGlnAla-163 168-ArgThrGlyLysLeu-172 202-ValIleGluLysGlyAsp-207 213-ProArgMetCysProAlaAspGluAspIleAla-223 226-GluLeuSerAspLysArgLeuVal-233 251-GlyArgProSerGluAlaPheAspLeuProGlu-261 270-LeuGluSerLysAsnGlyLeu-276 280-HisArgGlnGluGlyVal-285 303 -SerLysThrSerCysThrArgProThrAlaAlaArgLysSerAla-317 328-ArgGlyIleProLysThrArgSerTrpArgAsn-338 900-2 AMPHI Regions - AMPHI 9-ValValAlaPheAlaArgPhe-15 36-ValGlyLysHisPheArgLysPheHisArgPheArgArgArgGlyGlu-51 53-PheValAspPheLysGlnTrpAlaPheValGlyLeuPheArgLeuAlaArgLeuPheHisIleGlyAspAspP heValAspArgPheLeuGlyPhePhe-85 121-GlyGluGluPheProGluAlaValValGluAlaAlaGlyAspValAlaArgHisPheAspValLeuAspLeu Val-145 161-SerHisGlnAsnArgIle-166 198-HisGlnThrLeuGlySerAspAlaGly-206 210-ValGlnPheHisHisPheGly-216 233-GlyLysProSerGlyGlyAsnGlyLeuGlyGlyLeuValAsnHisLeuArgLeuValAla-252 268-IleGluValLeuArgArgAlaAspGlyGly-277 279-AspGlyAlaAspValValAlaGlnMet-287 Antigenic Index - Jameson-Wolf l-LeuArgArgValGlyGlyGln-7 19-GlyValAspPheArgArgGlnLysPhePheGlyPheThrProArgGlnAlaVal-36 38-LysHisPheArgLysPheHisArgPheArgArgArgGlyGluGly-52 74-GlyAspAspPheValAspArg-80 88-PheProLysArgAsnGlyValAla-95 103-SerValGlnThrAspGlnGluPhe-llO 118-PheGlyGlnGlyGluGluPheProGlu-126 131-AlaAlaGlyAspValAlaArg-137 145-ValAlaProAspGly-149 157-GlnAsnIleGlySerHisGlnAsnArgIleThrGluGlnThrHisPhe-172 201-LeuGlySerAspAlaGlyGlnAsnProVal-210 230-GluSerAlaGlyLysProSerGlyGlyAsnGly-240 252-AlaPheAspAspThrValValIleGlyGluGluGluGluGlyPheGly-267 270-ValLeuArgArgAlaAspGlyGlyAlaAspGlyAlaAsp-282 285-AlaGlnMetArgAspAlaGlyGlyGlyTyrAlaGly-296 311-MetProSerGluArgGluLysAspValProIle-321 323-ProAspLeuProProThrSerSerArgGlnGlnThr-334 Hydrophilic Regions - Hopp-Woods l-LeuArgArgValGly-5 20-ValAspPheArgArgGlnLys-26 38-LysHisPheArgLysPheHisArgPheArgArgArgGlyGluGly-52 89-ProLysArgAsnGly-93 105-GlnThrAspGlnGluPhe-110 120-GlnGlyGluGluPhePro-125 131-AlaAlaGlyAspValAlaArg-137 162-HisGlnAsnArgIleThrGlu-168 201-LeuGlySerAspAlaGlyGln-207 231-SerAlaGlyLysProSerGly-237 257-ValValIleGlyGluGluGluGluGlyPheGly-267 270-ValLeuArgArgAlaAspGlyGlyAlaAspGlyAlaAsp-282 285-AlaGlnMetArgAspAlaGly-291 311-MetProSerGluArgGluLysAspValProIle-321 326-ProProThrSerSerArgGlnGln-333 901-2 AMPHI Regions - AMPHI 20-GlyLeuPheThrValLeuGly-26 55-ValSerLeuThrGluIlePheSerLysSer-64 66-GluAlaPheAlaGluIleTyrAsp-73 84-AlaPheLeuAlaGlyMetGlyGlyIleAlaLeuIle-95 97-ArgLeuValProAsnProHisGluThrLeuAsp-107 124-ValGlyMetMetAlaAlaPhe-130 136-AsnPheProGluGlyLeuAlaThrPhePheAlaThrLeuGlu-149 164-HisAsnIleProGluGlyIleSer-171 190-CysLeuLeuSerGlyLeuAlaGluProLeuGlyAlaAla-202 217-PheGlySerValPheGlyValIleAlaGlyValMet-228 143-TyrSerAspGlyHisGlu-248 Antigenic Index - Jameson-Wolf l-MetProAspPheSerMet-6 33-SerLysThrProAsnProArgVal-40 61-PheSerLysSerSerGluAlaPhe-68 71-IleTyrAspLysAspHisAla-77 98-LeuValProAsnProHisGluThrLeuAspAlaGlnAspProSerPheGlnGluSerLysArgArgHisIleA la-122 136-AsnPheProGluGly-140 179-AlaThrArgSerArgLysLysThr-186 193-SerGlyLeuAlaGluProLeuGly-200 235-GluLeuLeuProAlaAlaLysArgTyrSerAspGlyHisGluThr-249 Hydrophilic Regions - Hopp-Woods 61-PheSerLysSerSerGluAlaPhe-68 71-IleTyrAspLysAspHisAla-77 102-ProHisGluThrLeuAspAlaGlnAspProSerPheGlnGluSerLysArgArgHisIleAla-122 180-ThrArgSerArgLysLysThr-186 235-GluLeuLeuProAlaAlaLysArgTyrSerAspGlyHisGlu-248 902 AMPHI Regions - AMPHI 1-LeuHisPheGlnArgIleIleLysCysSerGluGlyIleTrpAlaValGlyAlaArgProThrValGlyPhePh eGlyLysSerPheLysIleThrCysLysHisValValLeuArgArgArgThrValGlnAlaValAspPheThrThr CysLeuPheAlaValGlyHisPheValAspValProAlaTyrValPheAlaCysAspAlaHisThrGlyGlyValA laValLysArgValTyrGlyAlaAspValValGlnAsnSerGlyGlyAlaPheCysGlnThrGlnGlyArgArgGl AsnThrValPheGlylleMetPheGlnlleAlaGluGluProArgProAlaLeuArgAlaAlaProTyrHisAsn AlaValGlyGlyGlyLeuPheGluAspGlyLeuGlyPheLeuArgArgSerAsnValAlaValAspProAspArgA spValGlnThrAlaPheGlyPheGlyAspGluPheValThrArgPheAlaPheValHisLeuArgThrArgAlaSe rValAspGlyLysGlyGlyAspAlaAlallePheGlyAspPheGlyAspAspGlyGlnValLeuMetValValVal ProThrGlnThrGlyPheGluGlyAsnGlyTyrAlaCysArgThrAspAspGlyPheGlnAsnGlyGlyAsnGlnA rgLeuValLeuHisGlnArgAlaThrGlyLeuAspIleAlaAspPhePheSerGlyThrAlaHisValAspValAs pLysLeuArgProLysAlaAspValValThrArgGlylleArgHisLeuLeuArglleAlaSerGlyAsnLeuHis GlyAsnAsnAlaAlaPhelleGlyLysIleAlaAlaValGlnGlyPheSerSerlleSerGluArgArgValAlaG lyGlnHisPheAlaHisArgProThrCysAlaLysIleSerAlaLysSerAlaGluArgPheValGlyAsnAlaAr gHisArgArgLysCysAspGlyValValAspLysIleAlaAlaAspValHisAsnGlySerAlaPheGlnLysSer ThrProLeuTyrIlePhe-360 Antigenic Index - Jameson-Wolf 1-LeuHisPheGlnArgIleIleLysCysSerGluGlyIleTrpAlaValGlyAlaArgProThrValGlyPhePh eGlyLysSerPheLysIleThrCysLysHisValValLeuArgArgArgThrValGlnAlaValAspPheThrThr CysLeuPheAlaValGlyHisPheValAspValProAlaTyrValPheAlaCysAspAlaHisThrGlyGlyValA laValLysArgValTyrGlyAlaAspValValGlnAsnSerGlyGlyAlaPheCysGlnThrGlnGlyArgArgGl nAsnThrValPheGlylleMetPheGlnlleAlaGluGluProArgProAlaLeuArgAlaAlaProTyrHisAsn AlaValGlyGlyGlyLeuPheGluAspGlyLeuGlyPheLeuArgArgSerAsnValAlaValAspProAspArgA spValGlnThrAlaPheGlyPheGlyAspGluPheValThrArgPheAlaPheValHisLeuArgThrArgAlaSe rValAspGlyLysGlyGlyAspAlaAlallePheGlyAspPheGlyAspAspGlyGlnValLeuMetValValVal ProThrGlnThrGlyPheGluGlyAsnGlyTyrAlaCysArgThrAspAspGlyPheGlnAsnGlyGlyAsnGlnA rgLeuValLeuHisGlnArgAlaThrGlyLeuAspIleAlaAspPhePheSerGlyThrAlaHisValAspValAs pLysLeuArgProLysAlaAspValValThrArgGlylleArgHisLeuLeuArglleAlaSerGlyAsnLeuHis GlyAsnAsnAlaAlaPhelleGlyLysIleAlaAlaValGlnGlyPheSerSerlleSerGluArgArgValAlaG lyGlnHisPheAlaHisArgProThrCysAlaLysIleSerAlaLysSerAlaGluArgPheValGlyAsnAlaAr gHisArgArgLysCysAspGlyValValAspLysIleAlaAlaAspValHisAsnGlySerAlaPheGlnLysSer ThrProLeuTyrIlePhe-360 Hydrophilic Regions - Hopp-Woods 1-LeuHisPheGlnArgIleIleLysCysSerGluGlyIleTrpAlaValGlyAlaArgProThrValGlyPhePh eGlyLysSerPheLysIleThrCysLysHisValValLeuArgArgArgThrValGlnAlaValAspPheThrThr CysLeuPheAlaValGlyHisPheValAspValProAlaTyrValPheAlaCysAspAlaHisThrGlyGlyValA laValLysArgValTyrGlyAlaAspValValGlnAsnSerGlyGlyAlaPheCysGlnThrGlnGlyArgArgGl nAsnThrValPheGlylleMetPheGlnlleAlaGluGluProArgProAlaLeuArgAlaAlaProTyrHisAsn AlaValGlyGlyGlyLeuPheGluAspGlyLeuGlyPheLeuArgArgSerAsnValAlaValAspProAspArgA spValGlnThrAlaPheGlyPheGlyAspGluPheValThrArgPheAlaPheValHisLeuArgThrArgAlaSe rValAspGlyLysGlyGlyAspAlaAlallePheGlyAspPheGlyAspAspGlyGlnValLeuMetValValVal ProThrGlnThrGlyPheGluGlyAsnGlyTyrAlaCysArgThrAspAspGlyPheGlnAsnGlyGlyAsnGlnA rgLeuValLeuHisGlnArgAlaThrGlyLeuAspIleAlaAspPhePheSerGlyThrAlaHisValAspValAs pLysLeuArgProLysAlaAspValValThrArgGlylleArgHisLeuLeuArglleAlaSerGlyAsnLeuHis GlyAsnAsnAlaAlaPhelleGlyLysIleAlaAlaValGlnGlyPheSerSerlleSerGluArgArgValAlaG lyGlnHisPheAlaHisArgProThrCysAlaLysIleSerAlaLysSerAlaGluArgPheValGlyAsnAlaAr gHisArgArgLysCysAspGlyValValAspLysIleAlaAlaAspValHisAsnGlySerAlaPheGlnLysSer ThrProLeuTyrIlePhe-360 903-2 AMPHI Regions - AMPHI 29-GluLeuIleArgSerMetGlnArgGln-37 109-AsnLeuSerArgLeuGlnLysAla-116 191-GluGlnGlyLeuGluAsnLeuArgArgLeuProSerVal-203 240-GlyGlyLysThrThrGlyLysTyr-247 262-SerAspLeuPheTyr-266 315-ArgTyrHisGluAlaThrGlu-321 360-ThrArgGlnThrTyrLysTyrIleAspAsp-369 560-HisLysProLysGlyPheGlnThrThrAsnThr-570 Antigenic Index - Jameson-Wolf 21-LeuAlaAlaAspGluAsnAspAlaGluLeuIleArgSerMetGlnArgGlnGlnHisIleAsp-41 48-AlaAsnValArgPheGluGlnProLeuGluLysAsnAsnTyrValLeuSerGluAspGluThrProCysThrA rg-72 77-SerLeuAspAspLysThrValArg-84 106-GlySerAsnAsnLeuSerArgLeuGlnLysAlaAla-117 135-ProGlnAsnMetAspSerGlyIleLeu-143 146-ArgValSerAlaGlyGluIleGlyAspIleArgTyrGluGluLysArgAspGlyLysSerAlaGluGlySer Ile-170 178-ProLeuTyrArgAsnLysIleLeuAsn-186 188-ArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSerValLysThrAspIle-207 210-IleProSerGluGluGluGlyLysSerAspLeu-220 223-LysTrpGlnGlnAsnLysProIleArg-231 234-IleGlyIleAspAspAlaGlyGlyLysThrThrGlyLysTyrGlnGly-249 256-AspAsnProLeuGly-260 269-TyrGlyArgGlyLeuAlaHisLysThrAspLeuThrAspAlaThrGlyThrGluThrGluSerGlySerArg SerTyr-294 309-PheAsnHisAsnGlyHisArgTyrHisGluAlaThrGluGlyTyrSerValAsnTyrAspTyrAsnGlyLys GlnTyrGln-335 343-MetLeuTrpArgAsnArgLeuHisLysThrSerVal-354 362-GlnThrTyrLysTyrIleAspAspAlaGluIleGluValGlnArgArgArgSerAlaGlyTrpGluAlaGlu LeuArgHis-388 395-TrpGlnLeuAspGlyLysLeuSerTyrLysArgGlyThrGlyMetArgGlnSerMetProAlaProGluGlu AsnGlyGlyAspIleLeuProGlyThrSerArgMetLysIle-432 459-GlnTrpAsnLysThrPro-464 467-AlaGlnAspLysLeuSerIleGlySerArgTyrThrValArgGlyPheAspGlyGluGlnSerLeuPheGly GluArgGlyPheTyrTrpGlnAsnThr-499 514-AlaAspTyrGlyArgValSerGlyGluSerAla-524 527-ValSerGlyLysGln-531 539-PheArgGlyGlyHisLysValGly-546 557-LysProLeuHisLysProLysGlyPheGln-566 Hydrophilic Regions - Hopp-Woods 21-LeuAlaAlaAspGluAsnAspAlaGluLeuIleArgSerMetGlnArgGlnGlnHisIleAsp-41 48-AlaAsnValArgPheGluGlnProLeuGluLysAsnAsn-60 63-LeuSerGluAspGluThrProCys-70 77-SerLeuAspAspLysThrValArg-84 109-AsnLeuSerArgLeuGlnLysAlaAla-117 151-GluIleGlyAspIleArgTyrGluGluLysArgAspGlyLysSerAlaGluGlySer-169 188-ArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSerValLysThrAspIle-207 211-ProSerGluGluGluGlyLysSerAspLeu-220 234-IleGlyIleAspAspAlaGlyGlyLysThrThrGlyLysTyr-247 273-LeuAlaHisLysThrAspLeuThrAsp-281 283-ThrGlyThrGluThrGluSerGlySerArgSer-293 315-ArgTyrHisGluAlaThrGlu-321 366-TyrIleAspAspAlaGluIleGluValGlnArgArgArgSerAlaGlyTrp-382 384-AlaGluLeuArgHis-388 399-GlyLysLeuSerTyrLysArgGlyThrGlyMetArgGlnSerMetProAlaProGluGluAsnGlyGly-42 1 428-SerArgMetLysIle-432 467-AlaGlnAspLysLeuSerIle-473 481-GlyPheAspGlyGluGln-486 515-AspTyrGlyArgValSerGlyGluSer-523 558-ProLeuHisLysProLysGly-564 904-2 AMPHI Regions - AMPHI 23-AspPhePheAsnProPheGlnIleCysPheGlyValPheGlyGlnCysAla-39 55-PheValAsnArgLeuAlaGlyPheHisArgIleGly-66 89-PheAsnAlaValHisTyrIleGluPhe-97 131-GluPheValSerAlaPheCysGlnThrTyr-140 164-AlaGlnAsnIleIleGlnHisLeuArgThrTyrAlaArgAlaCysArgSerCysAlaArgGln-184 193-IleSerAlaValValAspVal-199 202-ArgThrLeuArgAlaPhe-207 250-GlyIleValGlnMetLeu-255 267-GlnPhePheThrGlnPhePheArgMetGlnGlnIleGlyGlyAlaAsn-282 308-ArgCysPheAlaGlyLeuValGlu-315 332-ThrAlaPheAspValPheHisAlaCys-340 364-ValGlnThrPheMetGlnAspAla-371 390-ArglleValAlaAlaLeu-395 402-GlyPhePheArgGlnProValAsn-409 418-ProLeuCysAlaAspTyrTyrAsnIlePheSerHis-429 Antigenic Index - Jameson-Wolf H-GlyAlaGlyGlyAspAspGlyAspArgArgAlaAlaAsp-23 66-GlyThrAlaArgGlnAspVal-72 84-AlaAspIleAspGly-88 98-SerAsnThrHisThrGlyAsn-104 106-ValAspLeuAspGly-110 114-GlyGlyGlyIleLys-118 126-SerGlyTyrArgThrGluPhe-132 147-PheGlyArgGluArgAlaArgThrAspAlaArgGlyIleGlyPheAspAspAlaGln-165 173-ThrTyrAlaArgAlaCysArgSerCysAlaArgGlnThrValGlyArgGlyAsnGluGlyIle-193 199-ValGlnGlnArgThrLeuArgAlaPheLys-208 224-HisValGlyAsnHisArgArgAsnAlaArgArgAspPhePheAspAsnArgHisHis-242 261-IleGlyLysAspGlyIle-266 279-GlyGlyAlaAsnGly-283 293-ArgAlaAspAlaAlaAlaGlyArgAla-301 314-ValGluArgAspValValArgGlnAspGlnArgAlaGlyArgArgAspPheGlnThr-332 351-GlyPheGlyGlyAspAspAsnAlaArgThrAspGluAlaVal-364 370-AspAlaAlaArgAsnGlnAlaGlnAsnGly-379 384-AspAsnGlnGlyMet-388 407-ProValAsnAspPhe-411 Hydrophilic Regions - Hopp-Woods 12-AlaGlyGlyAspAspGlyAspArgArgAlaAlaAsp-23 66-GlyThrAlaArgGlnAspVal-72 84-AlaAspIleAspGly-88 147-PheGlyArgGluArgAlaArgThrAspAlaArgGlyIleGlyPheAspAspAlaGln-165 173-ThrTyrAlaArgAlaCysArgSerCysAlaArg-183 185-ThrValGlyArgGlyAsnGluGly-192 199-ValGlnGlnArgThrLeuArgAlaPheLys-208 226-GlyAsnHisArgArgAsnAlaArgArgAspPhePheAspAsnArgHisHis-242 261-IleGlyLysAspGly-265 293-ArgAlaAspAlaAlaAlaGlyArgAla-301 314-ValGluArgAspValValArgGlnAspGlnArgAlaGlyArgArgAspPheGlnThr-332 352-PheGlyGlyAspAspAsnAlaArgThrAspGluAlaVal-364 370-AspAlaAlaArgAsnGlnAla-376 907-2 AMPHI Regions - AMPHI 42-AspAspValAlaSerValMetArgSer-50 66-LysGluGlyGluArgTrpLeuSerAlaMetSer-76 78-ArgLeuAlaArgPheVal-83 129-GlyAlaArgGlyLeu-133 142-AsnTyrIleGlyLysProAlaHis-149 165-LeuArgHisTyrArgAsnLeuGluLysGlyAsn-175 177-ValArgAlaLeuAlaArgPheAsnGly-185 Antigenic Index - Jameson-Wolf l-MetArgLysProThrAspThrLeuPro-9 12-LeuGlnArgArgArgLeuLeu-18 33-GlyAlaGlnArgGluGluThrLeuAlaAspAspValAlaSer-46 51-SerValGlySerValAsnProProArgLeuValPheAspAsnProLysGluGlyGluArgTrp-71 83-ValProGluGluGluGluArgArgArgLeu-92 97-GlnTyrGluSerSerArgAlaGlyLeu-105 115-GluValGluSerAlaPhe-120 142-AsnTyrIleGlyLysProAlaHisAsn-150 155-ArgThrAsnLeuArgTyrGly-161 168-TyrArgAsnLeuGluLysGlyAsnIle-176 184-AsnGlySerLeuGlySerAsnLysTyrProAsnAla-195 200-TrpArgAsnArgTrpGlnTrp-206 Hydrophilic Regions - Hopp-Woods 1-MetArgLysProThrAsp-6 12-LeuGlnArgArgArgLeuLeu-18 33-GlyAlaGlnArgGluGluThrLeuAlaAspAspValAlaSer-46 60-LeuValPheAspAsnProLysGluGlyGluArgTrp-71 83-ValProGluGluGluGluArgArgArgLeu-92 99-GluSerSerArgAlaGlyLeu-105 115-GluValGluSerAlaPhe-120 169-ArgAsnLeuGluLysGlyAsnIle-176 908-2 AMPHI Regions - AMPHI 9-TyrLysGlnAsnLys-13 26-ThrAlaAlaGluLeu-30 127-ThrAspCysTyrArgSerTyrAspValLeuAspValArgGluPheSerHisPheSer-145 Antigenic Index - Jameson-Wolf 1-MetArgLysSerArgLeuSerArgTyrLysGlnAsnLysLeu-14 51-GlnAsnSerProHis-55 59-PheAspGlyGluValGluAlaAspGluSerTyrPheGlyGlyGlnArgLysGlyLysArgGlyArgGlyAlaA laGly-84 91-LeuLeuLysArgAsnGlyLysVal-98 115-IleArgGluGlnValLysProAspSerIleVal-125 127-ThrAspCysTyrArgSerTyrAsp-134 136-LeuAspValArgGlu-140 161-ArgThrThrLysProTyr-166 Hydrophilic Regions - Hopp-Woods l-MetArgLysSerArgLeuSerArgTyrLysGlnAsnLysLeu-14 59-PheAspGlyGluValGluAlaAspGluSerTyr-69 72-GlyGlnArgLysGlyLysArgGlyArgGlyAlaAlaGly-84 92-LeuLysArgAsnGlyLys-97 115-IleArgGluGlnValLysProAspSer-123 136-LeuAspValArgGlu-140 909 AMPHI Regions - AMPHI 71-GlyAsnAsnAlaAspGlu-76 Antigenic Index - Jameson-Wolf 22-ThrTyrGlnAspGlyAsnGlyLysThrAlaValArgGlnLysTyrProAlaGly-39 45-GlnAspGlySerTyrSerLysAsnMetAsnTyrAsnGlnTyrArgProGluArgHisAla-64 68-AsnGlnThrGlyAsnAsnAlaAspGluGluHisArgGlnHisTrpGlnLysProLysPheGlnAsnArg-90 Hydrophilic Regions - Hopp-Woods 23-TyrGlnAspGlyAsnGlyLysThrAlaValArgGlnLysTyr-36 58-TyrArgProGluArgHisAla-64 72-AsnAsnAlaAspGluGluHisArgGlnHisTrpGln-83 85-ProLysPheGlnAsnArg-90 910 AMPHI Regions - AMPHI 10-ValSerLeuSerAlaAla-15 22-SerAlaGluArgGlnIle-27 39-LysAlaValLysMetLeuGlu-45 58-AspHisTrpGlyLysPro-63 69-AlaTyrLysAspGlyArg-74 Antigenic Index - Jameson-Wolf 19-AlaGlyAspSerAlaGluArgGlnIleTyrGlyAspProHisPheGluGlnAsnArgThrLysAlaValLysM etLeuGluGlnArgGlyTyrGln-50 53-AspValAspAlaAspAspHisTrpGlyLysProValLeuGlu-66 68-GluAlaTyrLysAspGlyArgGluTyrAsp-77 83-ProAspLeuLysIleIleLysGluGlnLeuAspArg-94 Hydrophilic Regions - Hopp-Woods 21-AspSerAlaGluArgGlnIleTyr-28 31-ProHisPheGluGlnAsnArgThrLysAlaValLysMetLeuGluGlnArgGly-48 53-AspValAspAlaAspAspHisTrpGly-61 68-GluAlaTyrLysAspGlyArgGluTyrAsp-77 86-LysIleIleLysGluGlnLeuAspArg-94 911 AMPHI Regions - AMPHI 6-LeuGluPheTrpValGlyLeuPhe-13 43-ValTyrAlaAspPheGlyAspIleGly-51 97-ValSerAlaGlnIle-101 118-GlyAspThrGluAsnLeuAla-124 140-AsnLeuIleGlyLysPheMetThrSerPhe-149 Antigenic Index - Jameson-Wolf l-MetLysLysAsnIle-5 35-GlyGlySerAspLysThrTyr-41 48-GlyAspIleGlyGlyLeuLysValAsnAlaProValLys-60 74-LeuAspProLysSerTyrGlnAlaArgValArgLeuAspLeuAspGlyLysTyrGlnPheSerSerAspVal- 97 103-ThrSerGlyLeuLeuGly-108 115-GlnGlnGlyGlyAspThrGluAsn-122 149-PheAlaGluLysAsnAlaAspGlyGlyAsnAlaGluLysAlaAlaGlu-164 Hydrophilic Regions - Hopp-Woods l-MetLysLysAsnIle-5 36-GlySerAspLysThr-40 74-LeuAspProLysSerTyrGlnAlaArgValArgLeuAspLeuAspGly-89 116-GlnGlyGlyAspThrGluAsn-122 149-PheAlaGluLysAsnAlaAspGlyGlyAsnAlaGluLysAlaAlaGlu-164 912 AMPHI Regions - AMPHI 24-ProAlaAspAlaValSerGlnIle-31 62-PheAspPheGlnArgMetThrAlaLeuAlaValGlyAsnProTrpArgThrAlaSerAspAlaGlnLys-84 89-LysGluPheGlnThrLeu-94 169-TyrArgAsnGlnPheGlyGluIleIleLysAlaLys-180 Antigenic Index - Jameson-Wolf l-MetLysLysSerSer-5 29-SerGlnIleArgGlnAsnAlaThrGln-37 42-LeuLysAsnGlyAspAlaAsnThrAlaArgGlnLysAlaGluAla-56 74-AsnProTrpArgThrAlaSerAspAlaGlnLysGlnAlaLeuAlaLysGluPhe-91 104-LeuLysLeuLysAsnAlaAsnValAsnValLysAspAsnProIleValAsnLysGlyGlyLysGluIleIle Val-128 130-AlaGluValGlyValProGlyGlnLysProValAsn-141 146-ThrTyrGlnSerGlyGlyLysTyrArgThr-155 169-TyrArgAsnGlnPhe-173 177-IleLysAlaLysGlyValAspGlyLeuIleAla-187 189-LeuLysAlaLysAsnGlyGlyLys-196 Hydrophilic Regions - Hopp-Woods l-MetLysLysSerSer-5 31-IleArgGlnAsnAla-35 43-LysAsnGlyAspAlaAsnThrAlaArgGlnLysAlaGluAla-56 78-ThrAlaSerAspAlaGlnLysGlnAlaLeuAlaLysGluPhe-91 104-LeuLysLeuLysAsn-108 110-AsnValAsnValLysAspAsnProIleVal-119 121-LysGlyGlyLysGluIleIleVal-128 134-ValProGlyGlnLysProValAsn-141 177-IleLysAlaLysGlyValAsp-183 189-LeuLysAlaLysAsnGlyGlyLys-196 913 AMPHI Regions - AMPHI 22-GluThrArgProAlaAspProTyrGluGlyTyrAsnArg-34 53-ArgGlyTyrArgLysValAlaProLys-61 66-GlyValSerAsnPhePheAsnAsnLeuCysAspValValSer-79 107-LeuGlyGlyLeuIleAspIleAlaGlyAla-116 151-ValArgAspAlaLeuGlyThrGlyIleThrSerValTyrSer-164 193-AspLeuThrAspSerLeuAspGluAlaAla-202 238-LeuValGluSerAla-242 257-SerGluThrGlnAla-261 Antigenic Index - Jameson-Wolf 21-AlaGluThrArgProAlaAspProTyrGluGlyTyrAsn-33 39-PheAsnAspGlnAlaAspArgTyr-46 51-AlaAlaArgGlyTyrArgLysValAlaProLysProValArgAla-65 81-GlySerAsnIleLeu-85 87-LeuAspIleLysArgAlaSerGluAspLeuVal-97 117-GlyGlyIleProAspAsnLysAsnThrLeuGlyAsp-128 132-SerTrpGlyTrpLysAsnSerAsn-139 149-SerThrValArgAspAlaLeu-155 163-TyrSerProLysAsnIle-168 172-ThrProValGlyArgTrpGly-178 185-ValSerThrArgGluGlyLeuLeuAspLeuThrAspSerLeuAspGluAlaAlaIleAspLysTyrSerTyr ThrArgAspLeuTyrMet-214 216-ValArgAlaArgGlnThrGlyAlaThrProAlaGluGlyThrGluAspAsnIleAspIleAspGluLeuVal GluSerAlaGluThrGlyAlaAla-247 250-AlaValGlnGluAspSerValSerGluThrGlnAlaGluAlaAlaGlyGluAlaGluThrGlnProGlyThr GlnPro-275 Hydrophilic Regions - Hopp-Woods 21-AlaGluThrArgProAlaAspProTyrGluGlyTyrAsn-33 40-AsnAspGlnAlaAsp-44 53-ArgGlyTyrArgLysValAlaProLysProValArg-64 87-LeuAspIleLysArgAlaSerGluAspLeuVal-97 118-Gly11eProAspAsnLysAsnThrLeu-126 150-ThrValArgAspAlaLeu-155 186-SerThrArgGluGlyLeuLeuAspLeuThrAspSerLeuAspGluAlaAlaIleAsp-204 216-ValArgAlaArgGlnThrGly-222 224-ThrProAlaGluGlyThrGluAspAsnIleAspIleAspGluLeuValGluSerAlaGluThrGlyAlaAla -247 250-AlaValGlnGluAspSerValSerGluThrGlnAlaGluAlaAlaGlyGluAlaGluThrGlnPro-271 914-2 AMPHI Regions - AMPHI 6-LeuGlyIleLeuThrAlaCysAlaAlaMet-15 17-AlaPheAlaAspArgIleGlyAspLeu-25 65-PheGlnLysThrPheGlu-70 81-GlnLysValArgGlnAlaCys-87 Antigenic Index - Jameson-Wolf 18-PheAlaAspArgIleGlyAspLeuGluAlaArgLeuAlaGlnLeuGluHisArgValAlaValLeuGluSerG lyGlyAsnThrValLys-47 50-LeuPheGlySerAsnSer-55 64-ProPheGlnLysThrPheGluAlaSerAspArgAsnGluGlyValAlaArgGlnLysValArgGlnAlaCysA snArgGluThrSerAla-93 95-PheCysGluAspGluAlaIleArgCysArgLysPheAsp-107 Hydrophilic Regions - Hopp-Woods 18-PheAlaAspArgIleGlyAspLeuGluAlaArgLeuAlaGlnLeuGluHisArgValAlaVal-38 67-LysThrPheGluAlaSerAspArgAsnGluGlyValAlaArgGlnLysValArgGlnAlaCysAsnArgGluT hrSer-92 95-PheCysGluAspGluAlaIleArgCysArgLysPheAsp-107 915-2 AMPHI Regions - AMPHI 9-ValAlaValSerAlaLeuSerAlaCysArgGlnAla-20 31-IleSerAspArgSerVal-36 67-SerThrIleLysGlnMetPheGlyTyrThrLysLeuProGluGluProLysGlyIleArgValIleTyrValT hrAspMetGlyAsnValThrAspTrpThr-100 139-GlnAlaGluLysPhe-143 Antigenic Index - Jameson-Wolf 15-SerAlaCysArgGlnAlaGluGluGlyProProProLeuProArgGlnIleSerAspArgSerValGlyHis- 38 43-AsnLeuThrGluHisAsnGlyProLysAla-52 57-AsnGlyLysProAspGlnProVal-64 75-TyrThrLysLeuProGluGluProLysGlyIle-85 97-ThrAspTrpThrAsnProAsnAlaAspThrGluTrpMetAspAlaLysLys-113 125-GlyMetGlyAlaGluAspAlaLeuProPheGlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGly GlyLysValValGlyPheAspAspMetProAspThrTyr-161 Hydrophilic Regions - Hopp-Woods 18-ArgGlnAlaGluGluGlyProProProLeu-27 30-GlnIleSerAspArgSerVal-36 46-GluHisAsnGlyProLys-51 58-GlyLysProAspGln-62 77-LysLeuProGluGluProLysGlyIle-85 103-AsnAlaAspThrGluTrpMetAspAlaLysLys-113 127-GlyAlaGluAspAlaLeu-132 135-GlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGlyGlyLys-150 155-AspAspMetProAsp-159 917 AMPHI Regions - AMPHI 6-ProLeuAlaValLeuThrAlaLeuLeuLeu-15 35-GlnAsnValLeuLysIleTyrAsnTrpSerGluTyrValAspProGluThrValAlaAsp-54 99-IleLysAlaGlyAlaTyrGlnLysIleAspLysSerLeu-lll 124-ArgLeuMetAspGlyValAspPro-131 152-ArgValLysLysAlaLeu-157 188-AspSerAlaAlaGlu-192 206-AsnSerSerAsnThrGluAspIleArgGluAlaThr-217 292-AlaLysAsnValAlaAsnAlaHisLysTyrIleAsnAspPheLeuAsp-307 325-LysProAlaArgGluLeuMetGluAsp-333 Antigenic Index - Jameson-Wolf 18-CysGlyGlySerAspLysProProAlaGluLysProAlaProAlaGluAsnGlnAsnVal-37 44-SerGluTyrValAspProGluThrValAlaAspPheGluLysLysAsnGlyIleLysValThr-64 68-TyrAspSerAspGluThrLeuGluSerLysValLeuThrGlyLysSerGlyTyrAsp-86 102-GlyAlaTyrGlnLysIleAspLysSerLeuIleProAsnTyrLysHisLeuAsnProGluMetMetArgLeu MetAspGlyValAspProGlyHisGluTyr-135 149-AsnThrGluArgValLysLysAlaLeuGlyThrAspLysLeuProAspAsnGln-166 171-PheAspProGluTyrThrSerLysLeuLysGlnCysGly-183 201-LeuGlyLysAsnProAsnSerSerAsnThrGluAspIleArgGluAlaThrAlaLeuLeuLysLysAsnArg ProAsnIleLysArgPheThrSerSerGlyPheIle-236 238-AspLeuAlaArgGlyAspThr-244 255-AsnIleAlaLysArgArgAlaGluGluAlaGlyGlyLysGluLysIleArgValMetMetProLysGluGly ValGly-280 287-ValIleProLysAspAlaLysAsnValAlaAsn-297 305-PheLeuAspProGluValSerAlaLysAsnGlyAsn-316 320-TyrAlaProSerSerLysProAlaArgGluLeuMetGluAspGluPheLysAsnAspAsnThrIlePhePro ThrGluGluAspLeuLysAsn-350 368-GlnTrpGlnAspValLysAlaGlyLys-376 Hydrophilic Regions - Hopp-Woods 19-GlyGlySerAspLysProProAlaGluLysProAlaProAlaGluAsn-34 47-ValAspProGluThrValAlaAspPheGluLysLysAsnGlyIle-61 68-TyrAspSerAspGluThrLeuGluSerLysValLeuThr-80 105-GlnLysIleAspLysSerLeu-lll 121-GluMetMetArgLeuMetAspGlyValAspProGlyHis-133 149-AsnThrGluArgValLysLysAlaLeuGlyThrAspLysLeuProAspAsnGln-166 174-GluTyrThrSerLysLeuLysGln-181 204-AsnProAsnSerSerAsnThrGluAspIleArgGluAlaThrAlaLeuLeuLysLysAsnArgProAsnIle LysArgPheThr-231 238-AspLeuAlaArgGlyAspThr-244 255-AsnIleAlaLysArgArgAlaGluGluAlaGlyGlyLysGluLysIleArgValMetMetProLysGluGly -278 290-LysAspAlaLysAsnValAlaAsn-297 305-PheLeuAspProGluValSerAlaLysAsn-314 322-ProSerSerLysProAlaArgGluLeuMetGluAspGluPheLysAsnAspAsn-339 343-ProThrGluGluAspLeuLysAsn-350 370-GlnAspValLysAlaGlyLys-376 919 AMPHI Regions - AMPHI 12-GlyIleAlaAlaAlaIleLeu-18 24-LysSerIleGlnThrPheProGln-31 37-IleAsnGlyProAspArgProValGlyIleProAsp-48 76-AspPheAlaLysSerLeuGln-82 98-GlnAspValCysAlaGlnAlaPheGlnThrProVal-109 119-GluArgTyrPheThr-123 133-LeuAlaGlyThrValThrGlyTyrTyrGlu-142 161-GlyIleProAspAspPheIleSerValPro-170 176-ArgSerGlyLysAlaLeuValArglleArgGln-186 191-SerGlyThrIleAspAsnThrGlyGlyThr-200 307-MetGlnGlyIleLysSerTyrMetArgGlnAsnProGlnArgLeuAlaGluValLeu-325 348-AlaLeuGlyThrProLeuMetGlyGluTyrAlaGlyAlaVal-361 382-ArgLysAlaLeuAsnArg-387 Antigenic Index - Jameson-Wolf 21-CysGlnSerLysSerIleGlnThr-28 30-ProGlnProAspThr-34 36-ValIleAsnGlyProAspArgProValGlyIleProAspProAlaGlyThr-52 54-ValGlyGlyGlyGly-58 76-AspPheAlaLysSerLeuGln-82 87-GlyCysAlaAsnLeuLysAsnArgGlnGlyTrpGln-98 121-TyrPheThrProTrp-125 143-ProValLeuLysGlyAspAspArgArgThrAlaGln-154 162-IleProAspAspPheIle-167 173-AlaGlyLeuArgSerGlyLysAlaLeuValArgIleArgGlnThrGlyLysAsnSerGlyThrIleAspAsn ThrGlyGlyThrHis-201 215-ThrAlaIleLysGlyArgPheGluGlySerArgPheLeuProTyrHisThrArgAsnGlnIleAsnGlyGly AlaLeuAspGlyLysAlaPro-245 250-AlaGluAspProValGlu-255 262-GlnGlySerGlyArgLeuLysThrProSerGlyLysTyrIleArg-276 278-GlyTyrAlaAspLysAsnGluHisPro-286 293-TyrMetAlaAspLysGlyTyrLeuLysLeuGlyGln-304 308-GlnGlyIleLysSerTyrMetArgGlnAsnProGlnArgLeuAlaGlu-323 326-GlyGlnAsnProSer-330 337-LeuAlaGlySerSerAsnAspGlyProVal-346 359-GlyAlaValAspArgHisTyr-365 379-ProValThrArgLysAlaLeuAsn-386 393-AspThrGlySerAlaIleLysGlyAlaValArg-403 409-GlyTyrGlyAspGluAlaGlyGluLeuAlaGlyLysGlnLysThrThr-424 431-LeuProAsnGlyMetLysProGluTyrArgPro-441 Hydrophilic Regions - Hopp-Woods 38-AsnGlyProAspArgProValGly-45 90-AsnLeuLysAsnArgGlnGlyTrp-97 144-ValLeuLysGlyAspAspArgArgThrAlaGln-154 175-LeuArgSerGlyLysAlaLeuValArgIleArgGlnThrGlyLysAsnSerGlyThrIleAspAsnThrGly -198 215-ThrAlaIleLysGlyArgPheGluGly-223 239-AlaLeuAspGlyLysAla-244 250-AlaGluAspProVal-254 265-GlyArgLeuLysThrProSer-271 279-TyrAlaAspLysAsnGluHis-285 317-AsnProGlnArgLeuAlaGlu-323 337-LeuAlaGlySerSerAsnAspGlyPro-345 380-ValThrArgLysAlaLeuAsn-386 393-AspThrGlySerAlalle-398 412-AspGluAlaGlyGluLeuAlaGlyLysGlnLysThr-423 434-GlyMetLysProGluTyrArgPro-441 920-2 AMPHI Regions - AMPHI 43-GlyGluPheProGluLeuGluProIleAla-52 117-GlyIleLysGluMetProAsp-123 135-LysAsnIleValAsnVal-140 163-LeuAspAsnProAlaAsn-168 190-ThrValThrAlaThrPheAspGlyPheAspThrSerAspArgSerLys-205 212-GlnAlaPheSerAspSerThr-218 Antigenic Index - Jameson-Wolf 40-LeuGlyTyrGlyGluPheProGlu-47 49-GluProIleAlaLysAspArgLeu-56 66-ValThrGluLysGlyLysGluAsnMetIle-75 77-ArgGlyThrTyrAsnTyrGlnTyrArgSerAsnArgProValLysAspGlySerTyr-95 104-ThrPheTrpSerLysAsnLysAlaGlyTrp-113 116-AlaGlyIleLysGluMetProAspAlaSerTyrCysGluGlnThrArgMetPheGlyLysAsnIleValAsn ValGlyHisGluSerAlaAspThr-147 152-LysProValGlyGlnAsnLeuGlu-159 162-ProLeuAspAsnProAla-167 173-GluArgPheLysVal-177 181-PheArgGlyGluProLeuProAsnAla-189 194-ThrPheAspGlyPheAspThrSerAspArgSerLysThrHisLysThrGluAla-211 213-AlaPheSerAspSerThrAspAspLysGlyGluValAsp-225 237-AsnValGluHisLysThrAspPheProAspGlnSerValCysGlnLysGlnAlaAsnTyrSer-257 Hydrophilic Regions - Hopp-Woods 49-GluProIleAlaLysAspArgLeu-56 66-ValThrGluLysGlyLysGluAsnMetIle-75 85-ArgSerAsnArgProValLysAspGlySer-94 107-SerLysAsnLysAlaGlyTrp-113 116-AlaGlyIleLysGluMetProAsp-123 128-GluGlnThrArgMetPheGly-134 142-HisGluSerAlaAsp-146 173-GluArgPheLysVal-177 196-AspGlyPheAspThrSerAspArgSerLysThrHisLysThrGluAla-211 213-AlaPheSerAspSerThrAspAspLysGlyGluValAsp-225 237-AsnValGluHisLysThrAspPheProAsp-246 248-SerValCysGlnLys-252 921 AMPHI Regions - AMPHI 12-AlaValLeuSerGlyCysGlnSerIleTyrValProThrLeuThrGluIleProValAsn-31 33-IleAsnThrValLysThr-38 51-HisTrpThrAspValAlaLysIleSerAspGlu-61 72-GlyLysMetThrLysValGlnAlaAlaGlnTyrLeuAsnAsnPheArgLys-88 98-AspSerMetTyrGluIleTyrLeuArg-106 126-GlnAsnAlaLeuArgGlyTrpGlnGlnArg-135 Antigenic Index - Jameson-Wolf 36-ValLysThrGluAlaProAlaLysGlyPheArg-46 56-AlaLysIleSerAspGluAlaThrArg-64 72-GlyLysMetThrLys-76 84-AsnAsnPheArgLysArgLeuValGlyArgAsnAlaValAspAspSerMet-100 108-AlaIleAspSerGlnArgGlyAlaIleAsnThrGluGlnSerLys-122 128-AlaLeuArgGlyTrpGlnGlnArgTrpLysAsnMetAspValLysProAsnAsnProAla-147 Hydrophilic Regions - Hopp-Woods 36-ValLysThrGluAlaProAlaLysGlyPheArg-46 56-AlaLysIleSerAspGluAlaThrArg-64 86-PheArgLysArgLeuValGly-92 94-AsnAlaValAspAspSerMet-100 108-AlaIleAspSerGlnArgGlyAlaIleAsnThrGluGlnSerLys-122 136-TrpLysAsnMetAspValLysProAsnAsn-145 922 AMPHI Regions - AMPHI 16-LeuSerAlaCysThr-20 28-ArgAlaAsnGluAlaGlnAlaPro-35 37-AlaValGluMetLysLys-42 72-ValArgArgPheVa1AspAsp-78 89-GluTrpGlnAspPhePheAspLys-96 104-ValLysIleMetHis-108 144-AspAspValAlaGln-148 172-GlySerPheArgValAlaAspAlaLeu-180 196-LysGluLeuValGluLeuLeuLysLeuAla-205 222-AlaMetGlyMetPro-226 245-HisArgAspIleTrpGlyAsnValGlyAspValAlaAlaSerValAlaAsnTyrMetLysGlnHis-266 298-ArgThrValAlaAspLeuLysAlaTyr-306 335-TyrLeuGlyLeuAsnAsnPheTyrThr-343 Antigenic Index - Jameson-Wolf l-MetLysLysArgLysIleLeu-7 22-MetGluAlaArgProProArgAlaAsnGluAlaGlnAlaProArgAlaValGluMetLysLysGluSerArgP roAlaPhe-48 61-ValSerAspSerGlyPhe-66 70-AlaAsnValArgArgPheValAspAspGluValGlyLysGlyAspPheSerArgAlaGluTrp-90 107-MetHisArgProSerThrSerArgPro-115 120-ArgThrGlyAsnSerGlyLysAlaLysPheArgGlyAlaArgArgPheTyrAlaGluAsnArgAlaLeuIle -143 145-AspValAlaGlnLysTyrGlyVal-152 163-11eGluThrAsnTyrGlyLysAsnThrGlySer-173 186-AspTyrProArgArgAlaGlyPhePhe-194 203-LysLeuAlaLysGluGluGlyGlyAsp-211 229-MetProSerSerTyrArgLysTrpAlaValAspTyrAspGlyAspGlyHisArgAspIle-24. 266-HisGlyTrpArgThrGlyGlyLysMet-274 281-AlaProGlyAlaAsp-285 290-IleGlyGluLysThrAlaLeu-296 310-ProGlyGluGluLeuAlaAspAspGluLysAlaVal-321 326-GluThrAlaProGly-330 357-ValArgAspIleAlaAsnSerLeuGlyGlyProGlyLeu-369 Hydrophilic Regions - Hopp-Woods l-MetLysLysArgLysIleLeu-7 22-MetGluAlaArgProProArgAlaAsnGluAlaGlnAlaProArgAlaValGluMetLysLysGluSerArgP roAlaPhe-48 70-AlaAsnValArgArgPheValAspAspGluValGlyLysGlyAspPheSerArgAlaGluTrp-90 122-GlyAsnSerGlyLysAlaLysPheArgGlyAlaArgArgPheTyrAlaGluAsnArgAlaLeuIle-143 166-AsnTyrGlyLysAsnThrGly-172 187-TyrProArgArgAlaGlyPhePhe-194 203-LysLeuAlaLysGluGluGlyGlyAsp-211 240-TyrAspGlyAspGlyHisArgAspIle-248 290-IleGlyGluLysThrAlaLeu-296 310-ProGlyGluGluLeuAlaAspAspGluLysAlaVal-321 357-ValArgAspIleAla-361 923-2 AMPHI Regions - AMPHI 9-LeuMetAlaCysAlaAlaPheLeu-16 26-LeuGlyAlaCysTyrAlaIleLeuSerLeuTyrAla-37 63-ProAlaLeuLeuGlyGlyTrpValGlyAlaTyr-73 117-GlyValAlaSerProCysArgThrIleCysThrValCysGlyPheValAlaLeu-134 Antigenic Index - Jameson-Wolf 43-IleAspLysArgCysAlaIleArgGlyGlnArgArgIleProGluHisArgLeu-60 79-PheLysHisLysThrAlaLysLysArgPhe-88 Hydrophilic Regions - Hopp-Woods 43 -1leAspLysArgCysAlalleArgGlyGlnArgArglleProGluHisArgLeu-60 79-PheLysHisLysThrAlaLysLysArgPhe-88 925-1 AMPHI Regions - AMPHI 8-ValGlyValValAlaValLeu-14 116-LysCysGlyGlnThrAlaGlnAlaTyrArgAspAla-127 139-GlnHisLeuAlaAlaIleGluGlnLeuLys-148 155-PheAspGluLeuGlu-159 Antigenic Index - Jameson-Wolf 15-AlaGlyCysGlyLysAspAlaGlyGlyTyrGluGlyTyrTrpArgGluLysSerAspLysLysGluGlyMetI leAlaValLysLysGluLysGlyAsn-47 57-ThrGlyLysGluGluSerLeuLeuLeuSerGluLysAspGlyAla-71 75-AsnThrGlyIleGly-79 81-IleProIleLysLeuSerAspAspGlyLyεGluLeuTyrValGluArgArgGlnTyrValLysThrAspAlaA laMetLysAspLysIleIleAlaHisGlnLysLysCysGlyGlnThr-120 123-AlaTyrArgAspAlaArgAsnAlaLeuProSerAsnGlnThrTyr-137 145-GluGlnLeuLysArgArgPheGluAlaGluPheAspGluLeuGluLysGluIleLysCysAsnGlyArgSer ProAla-170 Hydrophilic Regions - Hopp-Woods 17-CysGlyLysAspAlaGlyGly-23 27-TyrTrpArgGluLysSerAspLysLysGluGlyMetIleAlaValLysLysGluLysGly-46 57-ThrGlyLysGluGluSerLeuLeuLeuSerGluLysAspGlyAla-71 81-IleProIleLysLeuSerAspAspGlyLysGluLeuTyrValGluArgArgGlnTyrValLysThrAspAlaA laMetLysAspLysIleIleAlaHisGlnLysLysCysGlyGln-119 123-AlaTyrArgAspAlaArgAsnAlaLeu-131 145-GluGlnLeuLysArgArgPheGluAlaGluPheAspGluLeuGluLysGluIleLysCysAsnGlyArgSer -168 926 AMPHI Regions - AMPHI 29-ProSerGluHisIleSerSerPhe-36 72-LeuGlySerThrLeuGlyGln-78 98-AlaGluSerAlaGluGluLeuSerArgGln-107 128-AlaGlyAlaProTyrArgIleLeuProAspGlyIle-139 151-AlaAspSerGlyGlyGlnVal-157 Antigenic Index - Jameson-Wolf 19-LeuProGlnAsnAsnGluAsnLeuTrpGlnProSerGluHisIleSer-34 37-AlaAlaGluGlyArgLeuAlaValLysAlaGluGlyLysGlySerTyrAla-53 70-ThrProLeuGlySer-74 79-LeuCysGlnAspArgAspGlyAlaLeu-87 89-ValAspGlyLysGlyAsnValTyr-96 99-GluSerAlaGluGluLeuSerArg-106 121-TrpAlaAspGlyArgArgValAla-128 134-IleLeuProAspGlyIleLeu-140 148-GlyArgThrAlaAspSerGlyGlyGln-156 177-GlyMetProSerGluThrGluThrProGluArgCysAlaAlaArgThrArg-193 Hydrophilic Regions - Hopp-Woods 37-AlaAlaGluGlyArgLeuAlaValLysAlaGluGlyLysGlySer-51 80-CysGlnAspArgAspGlyAlaLeu-87 89-ValAspGlyLysGly-93 99-GluSerAlaGluGluLeuSerArg-106 123-AspGlyArgArgValAla-128 149-ArgThrAlaAspSerGlyGlyGln-156 180-SerGluThrGluThrProGluArgCysAlaAlaArgThrArg-193 927-2 AMPHI Regions - AMPHI 13-LeuLeuThrAlaCys-17 48-SerTyrAspValAlaArgAspPheTyrLysGlu-58 120-LysGlyTrpGlnGlnAlaLeuPro-127 145-AsnProLysGlnIleArgAspTrpAsnAspLeuAlaLysAspGly-159 197-LysLeuValAlaSerIleLeu-203 223-ArgAsnIleGlyAspValLeu-229 275-ThrGlnLysThrAlaArgAla-281 283-LeuGluTyrLeuTrpSerGluProAlaGlnGluLeu-294 325-LysLysPheGlyGlyTrpAspAsnIleMetLysThr-336 Antigenic Index - Jameson-Wolf 18-SerProAlaAlaAspSerAsnHisProSerGlyGlnAsnAlaProAlaAsnThrGluSerAspGlyLysAsnI leThr-43 48-SerTyrAspValAlaArgAspPheTyrLysGluTyrAsnPro-61 67-TyrGlnSerGluHisProGlyThrSer-75 79-GlnGlnSerHisGlyGlySerSerLysGlnAla-89 104-AsnGlnSerSerAspIleAspLeuLeuGluLysLysGlyLeuVal-118 125-AlaLeuProAspHisAlaAlaProTyrThr-134 142-ArgLysAsnAsnProLysGlnIleArgAspTrpAsnAspLeuAlaLysAspGlyVal-160 166-AsnProLysThrSerGlyAsnGlyArg-174 185-LeuLysThrThrAsnGlyAsnGluGlnGluAlaGlnLys-197 203-LeuLysAsnThrProValPheGluAsnGlyGlyArgAlaAlaThr-217 220-PheThrGlnArgAsnIleGlyAsp-227 238-TyrValSerLysLysLeuThrGlnGlyGln-247 270-ValAlaLysLysGlyThrGlnLysThrAlaArgAla-281 300-LeuArgProArgAsnProGluValLeuAlaArgHisLysAlaAspPheProAspLeuAspThrPheSerPro GluLysLysPheGlyGlyTrp-330 337-TyrPheAlaAspGlyGlyIle-343 347-LeuThrAlaGlnLys-351 Hydrophilic Regions - Hopp-Woods 19-ProAlaAlaAspSerAsnHisProSer-27 33-AlaAsnThrGluSerAspGlyLysAsn-41 50-AspValAlaArgAspPheTyrLys-57 67-TyrGlnSerGluHisProGly-73 82-HisGlyGlySerSerLysGlnAla-89 105-GlnSerSerAspIleAspLeuLeuGluLysLysGlyLeuVal-118 142-ArgLysAsnAsnProLysGlnIleArgAspTrpAsnAspLeuAlaLysAspGlyVal-160 167-ProLysThrSerGlyAsnGly-173 187-ThrThrAsnGlyAsnGluGlnGluAlaGlnLys-197 211-AsnGlyGlyArgAlaAla-216 238-TyrValSerLysLysLeuThr-244 270-ValAlaLysLysGlyThrGlnLysThrAlaArgAla-281 300-LeuArgProArgAsnProGluValLeuAlaArgHisLysAlaAspPheProAsp-317 319-AspThrPheSerProGluLysLysPheGlyGly-329 347-LeuThrAlaGlnLys-351 929-2 AMPHI Regions - AMPHI 25-ValProAspGlyValLys-30 34-TrpThrLeuLeuAlaMetPheValGlyValIleAlaAlaIleIle-48 76-GlyAlaAlaMetSerAspAlaLeuSerAlaPhe-86 155-HisProIleMetGlnSerIleAlaGlySerTyrGlySerAsnProAlaLys-171 180-TyrLeuAlaLeuVal-184 204-ProLeuIleValAsnLeuIleAlaGluAsnLeuGly-215 233-GlyValIleAlaPhePhe-238 265-ArgLeuArgGluMetGlyLysMetSer-273 280-AlaValIlePheGlyIle-285 355-LeuGlyLeuIleLysTrpPheSerGlyValLeuAlaGluSerValGlyGlyLeu-372 398-ThrAlaHisIleThrAlaMetPheGlyAlaPhePheAla-410 452-TyrThrThrMetGlyGluTrpTrp-459 Antigenic Index - Jameson-Wolf 25-ValProAspGlyValLysProGln-32 71-ThrAlaAspLysProGlyAlaAlaMet-79 122-GlyArgLysThrLeuGlyIle-128 143-ThrProSerAsnThrAlaArgGlyGlyGly-152 163-GlySerTyrGlySerAsnProAlaLysGlyThrGluGlyLysMetGlyLys-179 187-HisSerAsnProIleSer-192 213-AsnLeuGlySerSerPhe-218 248-TyrProProGluIleLysGluThrProAsn-257 261-PheAlaLysAspArgLeuArgGluMetGlyLysMetSerAlaAspGluIle-277 328-AspValLeuLysGluLysSerAlaTrp-336 Hydrophilic Regions - Hopp-Woods 71-ThrAlaAspLysProGlyAlaAlaMet-79 146-AsnThrAlaArgGly-150 168-AsnProAlaLysGlyThrGluGlyLysMetGlyLys-179 250-ProGluIleLysGluThrProAsn-257 261-PheAlaLysAspArgLeuArgGluMetGlyLysMetSerAlaAspGluIle-277 328-AspValLeuLysGluLysSerAlaTrp-336 930-1 AMPHI Regions - AMPHI 8-LeuProAsnIleArg-12 69-AsnThrGlyGluThrValAsnGlnLeuMetGly-79 121-LeuHisAlaGlyAsnIleAsnGlnIleMetΞerLeu-132 147-IleLeuAlaAlaPro-151 165-ProSerTyrLeuArgSerIleArgIle-173 199-AspLeuLeuAsnLeuArgAsp-205 207-GluGlnGlyLeuGluAsnLeuLysArgLeuProThr-218 280-SerAspMetPheTyr-284 288-GlyArgSerIleGlyGlyThrProAsp-296 333-ArgTyrHisGlnAlaValSerGlyLeuSerGluValTyrAsp-346 400-TrpLeuAlaGluLeu-404 427-MetLysAspAlaLeuArgAlaProGluGluAlaPheGlyGluGly-441 472-HisAlaGlnTrpAsnLys-477 Antigenic Index - Jameson-Wolf 32-SerProAsnProAlaGluIleArgMetGlnGlnAspIleGlnGlnArgGlnArgGluGluGlnLeuArgGlnT hrMetGlnProGluSerAspValArgLeuHisGlnLysAsnThrGlyGluThr-73 77-LeuMetGlyAspAspSerSerGln-84 93-ValLeuGluGlyGluHisHisAla-100 108-ArgAlaLeuArgGluThrGly-114 118-GlyLysCysLeuHisAlaGlyAsn-125 151-ProGlnAspLeuAsnSerGlyLysLeu-159 171-IleArgIleAspArgSerAsnAspAspGlnThrHis-182 191-AsnLysPheProThrArgSerAsnAspLeuLeuAsn-202 204-ArgAspLeuGluGlnGlyLeuGluAsnLeuLysArgLeuProThrAlaGluAlaAspLeu-223 228-ValGluGlyGluProAsnGlnSerAspVal-237 242-ArgGlnArgLeuLeuPro-247 252-ValGlyMetAspAsnSerGlySerGluAlaThrGlyLysTyrGlnGly-267 273-AlaAspAsnProLeuGlyLeu-279 287-TyrGlyArgSerIleGlyGlyThrProAspGluGluSerPheAspGlyHisArgLysGluGlyGlySerAsn -310 329-HisAsnGlyTyrArg-333 343-GluValTyrAspTyrAsnGlyLysSerTyrAsnThrAspPheGlyPhe-358 362-LeuTyrArgAspAlaLysArgLysThr-370 377-TrpMetArgGluThrLysSerTyrIleAspAspAlaGluLeuThrValGlnArgArgLysThrAla-398 408-GluTyrIleGlyArgSerThrAlaAspPheLysLeuLysTyrLysArgGlyThrGlyMetLysAspAlaLeu ArgAlaProGluGluAlaPheGlyGluGlyThrSerArg-444 451-SerAlaAspValAsnThrPro-457 474-GlnTrpAsnLysThrProLeuThrSerGlnAspLysLeuAla-487 492-HisThrValArgGlyPheAspGlyGluMet-501 503-LeuSerAlaGluArgGlyTrpTyrTrpArgAsnAspLeuSerTrpGlnPheLysProGlyHis-523 535-SerGlyGlnSerAlaLys-540 572-ArgAlaLeuLysLysProGluPhePheGlnSerArgLysTrpAlaSerGly-588 Hydrophilic Regions - Hopp-Woods 34-AsnProAlaGluIleArgMetGlnGlnAspIleGlnGlnArgGlnArgGluGluGlnLeuArgGln-55 57-MetGlnProGluSerAspValArgLeuHisGlnLysAsnThrGlyGluThr-73 78-MetGlyAspAspSerSerGln-84 93-ValLeuGluGlyGluHisHisAla-100 108-ArgAlaLeuArgGluThrGly-114 152-GlnAspLeuAsnSerGlyLys-158 171-IleArgIleAspArgSerAsnAspAspGlnThrHis-182 193 -PheProThrArgSerAsnAsp-199 204-ArgAspLeuGluGlnGlyLeuGluAsnLeuLysArgLeuProThrAlaGluAlaAspLeu-223 228-ValGluGlyGluProAsnGlnSer-235 254-MetAspAsnSerGlySerGluAlaThrGly-263 291-IleGlyGlyThrProAspGluGluSerPheAspGlyHisArgLysGluGlyGlySer-309 345-TyrAspTyrAsnGly-349 362-LeuTyrArgAspAlaLysArgLysThr-370 377-TrpMetArgGluThrLysSerTyrIleAspAspAlaGluLeuThrValGlnArgArgLysThr-397 413-SerThrAlaAspPheLysLeuLysTyrLysArgGlyThrGlyMetLysAspAlaLeuArgAlaProGluGlu AlaPheGly-439 479-ProLeuThrSerGlnAspLysLeuAla-487 495-ArgGlyPheAspGlyGluMet-501 503-LeuSerAlaGluArg-507 572-ArgAlaLeuLysLysProGluPhePheGln-581 931-2 AMPHI Regions - AMPHI 43-LysAlaProLysThrValAlaAsnPheValArgTyrAlaArgLys-57 65-PheHisArgValIleAspGly-71 81-GluAspLeuAlaGlnLysAlaSerAspLys-90 94-AsnGluSerGlyAsnGlyLeuLysAsnThr-103 142-ThrValPheGlyArgValGluSerGlyMetAsnThrValSerLysIleAlaArgValLysThrAlaThrArg GlyPhe-167 Antigenic Index - Jameson-Wolf l-MetLysProLysPhe-5 30-ThrAspMetGlyAsn-34 38-ValLeuAspGluSerLysAlaProLysThr-47 53-ArgTyrAlaArgLysGlyPheTyrAspAspThrValPhe-65 76-GlyGlyGlyLeuThrGluAspLeuAlaGlnLysAlaSerAspLysAlaValAlaAsnGluSerGlyAsnGlyL euLysAsnThrAla-104 110-AlaArgThrThrAlaProAspSerAlaThr-119 128-AspAsnAlaSerLeuAspTyrLysAsnGlyGlnTyr-139 145-GlyArgValGluSerGlyMetAsnThrVal-154 156-LysIleAlaArgValLysThrAlaThrArgGlyPhe-167 176-ValLysIleArgArg-180 Hydrophilic Regions - Hopp-Woods l-MetLysProLysPhe-5 30-ThrAspMetGlyAsn-34 38-ValLeuAspGluSerLysAlaProLysThr-47 78-GlyLeuThrGluAspLeuAlaGlnLysAlaSerAspLysAlaValAlaAsnGluSerGlyAsnGlyLeuLysA snThrAla-104 113-ThrAlaProAspSerAlaThr-119 130-AlaSerLeuAspTyrLysAsn-136 145-GlyArgValGluSerGlyMet-151 156-LysIleAlaArgValLysThrAlaThr-164 176-ValLysIleArgArg-180 932 AMPHI Regions - AMPHI 27-AspAlaAlaSerPheTrpGluLeuLysAsn-36 38-AlaAsnProTyrPro-42 46-ΞerAlaAlaLeuAspGlnTyrProSer-54 60-GlnLeuLysAspMetGlnGluCys-67 Antigenic Index - Jameson-Wolf 18-PheGlyGlyPheLysProAsnProTrpAsp-27 34-LeuLysAsnTyrAlaAsnProTyrProGlySer-44 50-AspGlnTyrProSerLysAlaArgArgArgGlnLeuLysAspMetGlnGluCysGlyTyrAspProIleAspG lyGlyLysSerGluAlaAspAlaCysLeuArgLysLysGlyTrpCysArgLysGlyPheAspProTyrProGluAs nLysLysTyrGluTrpProArgGluGluGlyLysThrLys-112 Hydrophilic Regions - Hopp-Woods 52-TyrProSerLysAlaArgArgArgGlnLeuLysAspMetGlnGluCysGlyTyrAspProIleAspGlyGlyL ysSerGluAlaAspAlaCysLeuArgLysLysGlyTrpCys-89 91-LysGlyPheAspProTyrProGluAsnLysLysTyrGluTrpProArgGluGluGlyLysThrLys-112 933 AMPHI Regions - AMPHI 6-LysThrSerGluTyr-10 37-GlnPheGluAsnl1eAsnAsnSerLysLys-46 61-GlyPheAlaArgGlyLeu-66 75-ThrGluGluGlnIleArgLysTyrPheLysGluCysPheAsn-88 94-ArgAspTyrSerThrCysGlnAla-101 133-SerValGlyAsnTyrThrGluTrpAlaAsnGlnValIleHisHisIleGluAsnTyrValSerPheAlaAla HisLeuTyrSerGlyLeuAspProPheHisTyrIleGluVal-170 261-GluAsnProIleAspAspLeuLysSerLeuAspGlyHisGlnIleIleLysValAsn-279 308-GlyPhePheThrLys-312 355-TrpLeuArgValIleAspGlyHisSerAsn-364 373-ProValGluGlyTyrArgLysGly-380 430-AlaGlyValTyrAlaThrTrpHis-437 451-TrpMetGlnTyrGln-455 466-GlyThrGluArgPheThr-471 473-LysGlyIleThrAlaSer-478 482-GlyTyrAsnAlaLeuLeuAla-488 547-LeuTyrLysAsnIleAlaIleGlu-554 556-PheAlaAlaValAsn-560 605-PheAsnArgGlnThrGly-610 Antigenic Index - Jameson-Wolf l-LysLysLeuArgAspLysThrSerGluTyrTrpLysLysGluThr-15 19-ThrGluAspAsnProLysValProPro-27 32-TyrProArgThrTyrGln-37 39-GluAsnIleAsnAsnSerLysLysIleSer-48 50-TyrAspGlnGluTyrThrGluGlyTyr-58 67-GlyValAlaLysArgAsnGlyAspThrGluGluGlnIleArgLysTyrPheLys-84 86-CysPheAsnSerAsnThrLysIleArgAspTyrSerThrCysGlnAlaGluLysPheGlySerHisPro-108 118-LeuGlyProLysIleLysAsnSerHisIleAsnSerGluIle-131 159-TyrSerGlyLeuAspPro-164 169-GluValThrAspAsnSerHis-175 184-AspGluPheArgLeuGluAsnSerLeuTrpGluProArgTrpAspSerAsnValGlyLysLeuLysThrThr AsnAlaAspIleArgPheAsnThrLysSerGluSerLeuLeuValLysGluAspTyrAlaGlyGlyAlaArgPheA rgPheAlaTyrAspProLysGluAlaLysAsn-243 249-GluLysAsnValThrGlyThrSer-256 259-IlePheGluAsnProIleAspAspLeuLysSerLeuAspGlyHisGlnIleIle-276 278-ValAsnGlyThrAlaAspLysHisAlaPheArgLeuSerGlyLysHisGlnLysGly-296 302-LeuGlnGlnArgProGluGlyPhe-309 312-LysValGlnGluArgAspAspMet-319 336-ArgLeuAsnAsnLysAsnSerAspIlePheAspArgThrLeuProArgLysGlyLeu-354 359-IleAspGlyHisSerAsnGlnTrpValGlnGlyLysThrAlaProValGluGlyTyrArgLysGlyVal-38 1 391-GlnAsnGluSerAsnGlnLeu-397 402-MetGlyGlyGlnAlaGluGlnArgSerThrPheHisAsnProAspThrAspAsnLeuThr-421 423-GlyAsnValLysGly-427 439-LeuGlnAspLysGlnThrGlyAlaTyrAlaAspSer-450 455-GlnArgPheArgHisArgIleAsnThrGluAspGlyThrGluArgPheThrSerLysGlyIleThrAla-47 7 490-HisPheThrLysLysGlyAsnSerLeu-498 513-ValAsnGlyLysPheSerAspSerGluAsnAla-523 528-LeuGlySerArgGlnLeuGlnThr-535 566-LysProPheGlyValGluMetAspGlyGluArgArgValIleAsnAsnLysThrAlaIleGluSer-587 593-ValLysIleLysSer-597 604-ThrPheAsnArgGlnThrGlyLysHisHisGlnAlaLysGlnGly-618 Hydrophilic Regions - Hopp-Woods l-LysLysLeuArgAspLysThrSerGluTyrTrpLysLysGluThr-15 20-GluAspAsnProLys-24 42-AsnAsnSerLysLysIleSer-48 67-GlyValAlaLysArgAsnGlyAspThrGluGluGlnIleArgLysTyrPheLys-84 91-ThrLysIleArgAspTyrSer-97 100-GlnAlaGluLysPheGly-105 120-ProLysIleLysAsn-124 184-AspGluPheArgLeuGlu-189 195-ProArgTrpAspSerAsnValGlyLysLeuLysThrThrAsnAlaAspIleArgPheAsnThrLysSerGlu SerLeuLeuValLysGluAspTyrAlaGly-228 236-TyrAspProLysGluAlaLysAsn-243 250-LysAsnValThrGly-254 262-AsnProIleAspAspLeuLysSerLeuAsp-271 280-GlyThrAlaAspLysHisAlaPhe-287 289-LeuSerGlyLysHisGlnLys-295 303 -GlnGlnArgProGluGlyPhe-309 313-ValGlnGluArgAspAspMet-319 337-LeuAsnAsnLysAsnSerAspI1ePheAsp-346 375-GluGlyTyrArgLysGlyVal-381 392-AsnGluSerAsnGln-396 405-GlnAlaGluGlnArgSerThrPheHis-413 415-ProAspThrAspAsnLeuThr-421 439-LeuGlnAspLysGlnThr-444 455-GlnArgPheArgHisArgIleAsnThrGluAspGlyThrGluArgPheThrSer-472 490-HisPheThrLysLysGlyAsnSer-497 516-LysPheSerAspSerGluAsnAla-523 568-PheGlyValGluMetAspGlyGluArgArgValIleAsn-580 593-ValLysIleLysSer-597 607-ArgGlnThrGlyLysHisHisGlnAlaLysGlnGly-618 935 AMPHI Regions - AMPHI 41-ValSerAspLysTrpAla-46 56-AlaProArgValVal-60 72-LeuGluHisSerLeuArgAsp-78 87-LeuIleAlaSerLeuAlaAspLeuTyrAlaLysLeu-98 lll-AlaLeuLeuAlaLysLeuAlaGlyArgProAlaGluAlaValAlaArgTyrArgGlu-129 158-GluArgHisPheAlaGlu-163 172-ProValLeuGluAsnValGlyArgPheArgLysLysThrGlu-185 375-LysArgLeuGlyGluSerAlaThrValPheGlyGlyTrpGlnPheVal-390 415-AlaGlyTrpAlaGlnGluTrpArgGlnLeuGlyGlyLeu-427 435-TyrAlaArgArgAsnTyrLysGlyIleAlaAlaPhe-446 Antigenic Index - Jameson-Wolf 27-AlaIleLeuAspAspLysAlaLeu-34 39-ArgSerValSerAspLysTrpAlaGluSerAspTrpLysValGluAsnAspAlaProArgValValAspGlyA spPhe-64 70-LysMetLeuGluHisSerLeuArgAspAlaLeuAsnGlyAsnGln-84 97-LysLeuProAspTyrAspAla-103 108-ArgAlaArgAlaLeu-112 116-LeuAlaGlyArgProAlaGluAlaValAlaArgTyrArgGluLeuHisGlyGluAsnAlaAlaAspGluArg IleLeu-141 145-AlaAlaAlaGluPheAspAspPheArgLeuLysSerAlaGluArgHisPheAlaGluAlaAlaLysLeuAsp Leu-169 176-AsnValGlyArgPheArgLysLysThrGluGly-186 192-PheSerGlyGlyIle-196 199-AlaValAsnArgAsnAlaAsnAsnAlaAla-208 210-GlnTyrCysArgGlnAsnGlyGlyArgGln-219 224-SerArgAlaGluArgAlaAla-230 236-IleGluAlaGluLysLeuThrProLeuAlaAsp-246 253-ArgSerAsnIleGlyGlyThrSerTyr-261 263-PheSerLysLysSerAlaTyrAspAspGlyPheGlyArg-275 279-GlyTrpGlnTyrLysAsnAlaArgGlnThr-288 300-SerGlySerAspGlyPheAspAlaLysThrLysArgValAsnAsnArgArgLeuProProTyr-320 332-HisThrTyrArgProAsnProGlyTrp-340 347-GluHisTyrArgGlnArgTyrArgGluGlnAspArgAlaGluTyrAsnAsnGlyArgGlnAspGlyPheTyr -370 373-SerAlaLysArgLeuGlyGlu-379 392-PheValProLysArgGluThrVal-399 406-AlaAlaTyrArgArgAsnGlyValTyrAlaGly-416 425-GlyGlyLeuAsnSerArgValSerAlaSerTyrAlaArgArgAsnTyrLysGly-442 448-ThrGluAlaGlnArgAsnArgGluTrpAsn-457 463-SerHisAspLysLeuSerTyrLysGly-471 480-PheGlyArgThrGluSerAsnValProTyrAlaLysArgArgAsnSerGlu-496 501-AlaAspTrpArgPhe-505 Hydrophilic Regions - Hopp-Woods 27-AlaIleLeuAspAspLysAlaLeu-34 39-ArgSerValSerAspLysTrpAlaGluSerAspTrpLysValGluAsnAspAlaProArgValValAsp-61 70-LysMetLeuGluHisSerLeuArgAspAlaLeuAsn-81 108-ArgAlaArgAlaLeu-112 116LeuAlaGlyArgProAlaGluAlaValAlaArgTyrArgGluLeuHisGly-132 134-AsnAlaAlaAspGluArgIleLeu-141 145-AlaAlaAlaGluPheAspAspPheArgLeuLysSerAlaGluArgHisPheAlaGluAlaAlaLysLeuAsp Leu-169 176-AsnValGlyArgPheArgLysLysThrGluGly-186 200-ValAsnArgAsnAlaAsn-205 212-CysArgGlnAsnGlyGlyArgGln-219 224-SerArgAlaGluArgAlaAla-230 236-IleGluAlaGluLysLeuThrPro-243 265-LysLysSerAlaTyrAspAspGlyPheGly-274 283 -LysAsnAlaArgGlnThr-288 303-AspGlyPheAspAlaLysThrLysArgValAsnAsnArgArgLeuPro-318 348-HisTyrArgGlnArgTyrArgGluGlnAspArgAlaGluTyrAsnAsnGlyArgGlnAsp-367 373-SerAlaLysArgLeuGlyGlu-379 393-ValProLysArgGluThrVal-399 407-AlaTyrArgArgAsnGly-412 435-TyrAlaArgArgAsnTyrLys-441 449-GluAlaGlnArgAsnArgGluTrp-456 463-SerHisAspLysLeuSerTyr-469 480-PheGlyArgThrGluSer-485 489-TyrAlaLysArgArgAsnSerGlu-496 936-1 AMPHI Regions - AMPHI 10-ThrLeuIleAlaAlaIle-15 22-GlyCysValSerAlaVal-27 100-GlnPheValGlyGlnIle-105 112-AlaGluGlyValTyrAsnTyrIleThrValAlaSerLeuProArgThrAlaGlyAspIleAlaGlyAsp-13 4 Antigenic Index - Jameson-Wolf l-MetLysProLysProHisThrVal-8 33-ValGlyAlaLysSerAlaValAspArgArgThrThrGlyAlaGlnThrAspAspAsnValMet-53 56-ArgIleGluThrThrAlaArgSerTyrLeuArgGlnAsnAsnGlnThrLysGlyTyr-74 94-AlaThrGluGlyGluLysGlnPhe-101 106-AlaArgSerGluGlnAlaAla-112 124-LeuProArgThrAlaGlyAspIleAlaGlyAspThrTrpAsnThrSerLysValArgAla-143 149-SerProAlaThrGlnAlaArgValLys-157 172-ThrProGluGluGlnAlaGlnIleThr-180 Hydrophilic Regions - Hopp-Woods l-MetLysProLysProHisThr-7 37-SerAlaValAspArgArgThrThrGlyAlaGlnThrAspAspAsnValMet-53 56-ArgIleGluThrThrAla-61 68-AsnAsnGlnThrLysGlyTyr-74 94-AlaThrGluGlyGluLysGlnPhe-101 106-AlaArgSerGluGlnAlaAla-112 125-ProArgThrAlaGly-129 152-ThrGlnAlaArgValLys-157 172-ThrProGluGluGlnAlaGlnIle-179 937 AMPHI Regions - AMPHI 6-LeuProAlaLeuProAlaIleLeuProLeuSerThr-17 190-AsnGlySerLysThrLeuSer-196 Antigenic Index - Jameson-Wolf 27-AspIleMetThrAspLysGlyLysTrpLysLeuGluThr-39 44-LeuAsnSerGluAsnAsnArgAlaGluLeu-53 72-GluIleGlnGluAsnGlySerAsnThrAsp-81 95-GlyAsnThrAspIleTyrGlySerGlySer-104 108-HisGluGluArgLysLeuAspGlyAsnSerLysThrArgAsnLysArgMetSerAsp-126 135-PheLeuLysAspAspLysAsnProAla-143 151-ThrValTyrGluLysSerArgAsnLysAlaSerSerGlyLysSer-165 187-TyrArgIleAsnGlySerLysThrLeuSerAspGlyIleArgTyrLysSerGlyAsnTyr-206 217-AlaAsnAspArgIleSerLeuThrGlyGly-226 231-GlyArgGlnProAspArgThrAspGlyLysArgGluSerSerArgAsnThrSerThr-249 273-ValSerGlyGlnSerSerSerGluLeuLysPhe-283 Hydrophilic Regions - Hopp-Woods 27-AsplleMetThrAspLysGlyLysTrpLysLeu-37 47-GluAsnAsnArgAlaGluLeu-53 72-GluIleGlnGluAsnGlySerAsnThr-80 108-HisGluGluArgLysLeuAspGlyAsnSerLysThrArgAsnLysArgMetSerAsp-126 135-PheLeuLysAspAspLysAsnPro-142 151-ThrValTyrGluLysSerArgAsnLysAlaSerSer-162 193-LysThrLeuSerAspGlyIleArgTyrLysSer-203 217-AlaAsnAspArgIleSer-222 232-ArgGlnProAspArgThrAspGlyLysArgGluSerSerArgAsnThr-247 277-SerSerSerGluLeuLysPhe-283 939-2 AMPHI Regions - AMPHI 32-AlaThrValCysAla-36 90-AspGlnAspIleLeu-94 121-LysIleTyrArgGly-125 135-CysMetSerCysHisGly-140 151-SerGluIleGlnAlaTyrProArgLeuGlyGly-161 169-GluGlnMetAsnAlaTyrLys-175 185-GluAspIleAlaAsnArgMetSer-192 Antigenic Index - Jameson-Wolf 18-AlaSerProLysAlaAspValGluLysGlyLysGlnVal-30 40-AlaAlaAspGlyAsnSerGlyIle-47 66-IleGlyIleArgAspGlyLysArgThrHisGlySerAlaAlaVal-80 88-LeuSerAspGlnAspIle-93 102-LysGlnGlnProLysSerGlyGluAlaAsnProLysGluAsnProGluLeuGly-119 122-IleTyrArgGlyGlyLeuSerAspLysLysValPro-133 139-HisGlyProSerGlyAlaGlyMetProGlyGlyGlySerGluIleGlnAla-155 157-ProArgLeuGlyGlyGlnHisGln-164 172-AsnAlaTyrLysSerGlyGlnArgLysAsnThrIleMetGluAspIleAlaAsnArgMetSerGluGluAsp LeuLysAla-198 Hydrophilic Regions - Hopp-Woods 18-AlaSerProLysAlaAspValGluLysGlyLysGlnVal-30 40-AlaAlaAspGlyAsnSer-45 67-Glyl1eArgAspGlyLysArgThrHisGly-76 89-SerAspGlnAspIle-93 103-GlnGlnProLysSerGlyGluAlaAsnProLysGluAsnProGluLeuGly-119 126-GlyLeuSerAspLysLysValPro-133 175-LysSerGlyGlnArgLysAsnThrIleMetGluAspIleAlaAsnArgMetSerGluGluAspLeuLysAla -198 950 AMPHI Regions - AMPHI 33-GlyValHisLysSerAlaHisGly-40 71-AlaThrValLysLysThrHisLysHisThrLysAla-82 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnIle-5 23-AlaAlaAsnLysProAlaSerAsnAlaThrGlyValHisLysSerAlaHisGlySerCysGlyAlaSerLysS erAlaGluGlySerCysGlyAlaAlaGlySerLysAlaGlyGluGlyLysCysGlyGluGlyLysCysGlyAlaTh rValLysLysThrHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysGlyGluGly LysCysGlySerLys-102 Hydrophilic Regions - Hopp-Woods 23-AlaAlaAsnLysProAlaSer-29 33 -GlyValHisLysSerAlaHis-39 43-GlyAlaSerLysSerAlaGluGlySerCys-52 55-AlaGlySerLysAlaGlyGluGlyLysCysGlyGluGlyLysCys-69 71-AlaThrValLysLysThrHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysG lyGluGlyLysCysGlySerLys-102 951 AMPHI Regions - AMPHI 9-LysMetLeuThrValLeuThrAla-16 32-AspMetLysGlnProLysGluValGlyLysValPheArgLysGlnGlnArgTyr-49 64-ValGlyGluArgValAsn-69 129-TrpArgGlnIleGluProIleProGlyLys-138 157-HisLeuAspGlyLeuGluGluValLeuAla-166 191-AlaGlnLysAlaSerLysAlaValArgArg-200 206-GluHisLeuProGluAlaAla-212 230-GlyAlaLeuGlnArgLeuAlaLysLeu-238 256-LysTyrProGluIleLeuAspGlyPhePheGlu-266 280-MetGluIleMetAsnLeuValSerLeuHisArgLeuAspAspAla-294 327-ValIleAspGlyTyrAlaGluLys-334 336-TyrGlyArgGlyThrGlu-341 364-ValArgGlnTrpLeuLys-369 397-AlaLeuArgGlnIleGlyArgValArgLysLeuProGluGlnGln-411 418-AspAsnLeuSerLys11e-423 425-MetLeuAlaLeuSer-429 436-GluAlaLeuArgGlyLeuAspLysIleIleGluLys-447 479-SerAspLeuGluArgAlaPheArg-486 497-AsnLeuGlyTyrSer-501 565-HisLeuGlyGluVal-569 581-AspValTrpThrGlnAla-586 596-TrpArgGluThrLeu-600 Antigenic Index - Jameson-Wolf 25-AlaAlaGlyGlyGlyAlaGlyAspMetLysGlnProLysGluValGlyLysValPheArgLysGlnGlnArgT yrSerGluGluGluIleLysAsnGluArgAlaArgLeu-61 63-AlaValGlyGluArgValAsn-69 79-ThrAlaLeuGlnLysGlyGlnAla-86 98-GluArgThrLysSerProGluValAlaGluArgAlaLeuGlu-lll 128-LysTrpArgGlnIleGluProIleProGlyLysAlaGlnLysArgAlaGlyTrpLeuArgAsnValLeuArg GluArgGlyAsnGlnHisLeuAspGlyLeuGluGluValLeuAlaGlnAlaAspGluGlyGlnAsnArgArg-175 185-ValGlnGlnAspGlyLeuAlaGlnLysAlaSerLysAlaValArgArgAlaAlaLeuLys-204 221-GlnGlyArgGluLysGluLysAlaIle-229 234-ArgLeuAlaLysLeuAspThrGluIleLeuPro-244 252-LeuThrAlaArgLysTyrProGluIleLeuAspGlyPhePheGluGlnThrAspThrGlnAsn-272 289-HisArgLeuAspAspAlaTyrAla-296 302-LeuGluArgAsnProAsnAlaAsp-309 319-AlaAsnArgLysGluGlyAlaSer-326 330-GlyTyrAlaGluLysAlaTyrGlyArgGlyThrGluGluGlnArgSerArgAla-347 355-TyrAlaAspArgArgAspTyrAlaLys-363 366-GlnTrpLeuLysLysValSerAla-373 377-LeuPheAspLysGlyVal-382 389-ValGluLeuAspGlyGlyArgAlaAlaLeu-398 400-GlnIleGlyArgValArgLysLeuProGluGlnGlnGlyArgTyrPheThr-416 430-LysLeuProAspLysArgGluAlaLeuArgGlyLeuAspLysIleIleGluLysProProAlaGlySerAsn ThrGluLeuGlnAla-458 470-ArgLeuGlyLysArgLysLysMetIleSerAspLeuGluArgAlaPheArgLeuAlaProAspAsn-491 504-ThrAspSerLysArgLeuAspGluGlyPhe-513 522-IleAsnProAspAspThrAlaValAsnAspSerIle-533 539-LeuLysGlyAspAlaGluSerAla-546 551-ArgTyrSerPheGluAsnAspProGluProGluVal-562 574-GlyGluArgAspGlnAla-579 588-HisLeuThrGlyAspLysLysIleTrpArgGluThrLeuLysArgHisGlyIleAlaLeuProGlnProSer ArgLysProArgLys-616 Hydrophilic Regions - Hopp-Woods 29-GlyAlaGlyAspMetLysGlnProLysGluValGlyLysValPheArgLysGlnGlnArgTyrSerGluGluG luIleLysAsnGluArgAlaArgLeu-61 63-AlaValGlyGluArgValAsn-69 79-ThrAlaLeuGlnLysGlyGlnAla-86 98-GluArgThrLysSerProGluValAlaGluArgAlaLeuGlu-lll 135-IleProGlyLysAlaGlnLysArgAlaGlyTrp-145 149-ValLeuArgGluArgGlyAsnGlnHis-157 159-AspGlyLeuGluGluValLeuAlaGlnAlaAspGluGlyGlnAsnArgArg-175 189-GlyLeuAlaGlnLysAlaSerLysAlaValArgArgAlaAlaLeuLys-204 221-GlnGlyArgGluLysGluLysAlaIle-229 234-ArgLeuAlaLysLeuAspThrGluIle-242 252-LeuThrAlaArgLysTyrProGluIle-260 265-PheGluGlnThrAspThrGlnAsn-272 289-HisArgLeuAspAspAlaTyrAla-296 302-LeuGluArgAsnProAsn-307 319-AlaAsnArgLysGluGlyAlaSer-326 331-TyrAlaGluLysAlaTyrGlyArgGlyThrGluGluGlnArgSerArgAla-347 355-TyrAlaAspArgArgAspTyrAlaLys-363 389-ValGluLeuAspGlyGlyArgAlaAlaLeu-398 400-GlnIleGlyArgValArgLysLeuProGluGlnGlnGly-412 430-LysLeuProAspLysArgGluAlaLeuArgGlyLeuAspLysIleIleGluLysProProAla-450 452-SerAsnThrGluLeuGlnAla-458 470-ArgLeuGlyLysArgLysLysMetIleSerAspLeuGluArgAlaPheArgLeuAlaProAspAsn-491 504-ThrAspSerLysArgLeuAspGlu-511 523-AsnProAspAspThrAlaVal-529 541-GlyAspAlaGluSer-545 554-PheGluAsnAspProGluProGluVal-562 574-GlyGluArgAspGlnAla-579 590-ThrGlyAspLysLysIleTrpArgGluThrLeuLysArgHisGly-604 609-GlnProSerArgLysProArgLys-616 952 AMPHI Regions - AMPHI 63-SerValAlaThrLeuLeuAsnAsnPheTyrGlyGln-74 81-ValLeuLysLysLeuAsp-86 94-PheGluAspMetArgArgIle-100 116-GluGlnLeuAlaGlnLeu-121 138-SerValLeuArgGlyIleAsp-144 163-AlaGlnPheLeuAspAla-168 179-LysIleLeuAlaVal-183 Antigenic Index - Jameson-Wolf 40-GlnSerTrpLysAlaArgArgAspPheAsnIleValLysGlnAspLeuAspPheSerCys-59 70-AsnPheTyrGlyGlnThrLeuThrGluGluGluValLeuLysLysLeuAspLysGluGlnMetArgAlaSerP heGluAspMetArgArgIleMetPro-102 104-LeuGlyPheGluAlaLysGlyTyr-lll 129-LeuLysTyrArgLysAspAspHisPheSer-138 141-ArgGlyl1eAspGlyAsnThr-147 169-TrpGlnThrArgGluGlyAsnLeuAla-177 184-IleProLysLysAlaGluThrIleSer-192 199-GlnHisProLysArgGlnThrGlu-206 213-ArgGlnAlaArgAlaGlu-218 Hydrophilic Regions - Hopp-Woods 41-SerTrpLysAlaArgArgAspPheAsnIleValLysGlnAspLeuAspPhe-57 76-LeuThrGluGluGluValLeuLysLysLeuAspLysGluGlnMetArgAlaSerPheGluAspMetArgArgI leMetPro-102 104-LeuGlyPheGluAlaLysGly-110 130-LysTyrArgLysAspAspHisPheSer-138 169-TrpGlnThrArgGluGlyAsnLeu-176 184-IleProLysLysAlaGluThrIleSer-192 200-HisProLysArgGlnThrGlu-206 213-ArgGlnAlaArgAlaGlu-218 953 AMPHI Regions - AMPHI 39-AsnThrSerThrAsnValGlyGlyPheTyrGlyLeuThr-51 75-GlnSerGlySerGlnHisPheThrAspHisLeuLysSerAlaAspIlePheAspAlaAlaGln-95 151-GlyAspPheSerThrThr-156 Antigenic Index - Jameson-Wolf 22-TyrLysValAspGluTyrHisAla-29 38-PheAsnThrSerThrAsnVal-44 54-ValGluPheAspGlnAlaLysArgAspGlyLysIleAspIle-67 83-AspHisLeuLysSer-87 95-GlnTyrProAspIleArgPheValSer-103 105-LysPheAsnPheAsnGlyLysLysLeuValSer-115 122-MetHisGlyLysThrAlaProValLysLeuLysAlaGluLys-135 137-AsnCysTyrGlnSerProMetGluLysThrGluValCysGlyGlyAsp-152 154-SerThrThrIleAspArgThrLysTrpGly-163 174-LysSerValArgIle-17 180-IleGlnIleGluAlaAlaLysGln-187 Hydrophilic Regions - Hopp-Woods 22-TyrLysValAspGluTyrHisAla-29 54-ValGluPheAspGlnAlaLysArgAspGlyLysIleAspIle-67 83-AspHisLeuLysSer-87 108-PheAsnGlyLysLysLeuValSer-115 125-LysThrAlaProValLysLeuLysAlaGluLys-135 142-ProMetGluLysThrGluValCysGly-150 155-ThrThrIleAspArgThrLysTrp-162 174-LysSerValArgIle-178 180-IleGlnIleGluAlaAlaLysGln-187 954 AMPHI Regions - AMPHI 48-ArgAlaAlaArgPheArg-53 57-GlnGlyLeuGlyGlyAspPheGluArgPheLeuLysGly-69 74-GlnGluAsnLeuAlaLysTyrArgGluAsnIle-84 100-ProTyrArgValCysLysGlnAla-107 134-TyrGlnAsnTyrArgLysSerMetGlnGluCysArgLysThrIleThr-149 Antigenic Index - Jameson-Wolf 17-GlyGlnGluGlnSerGlnLysAlaAspAlaGlu-27 35-TyrGlnPheAlaAspGluLysGln-42 58-GlyLeuGlyGlyAspPheGluArgPheLeuLysGlyGluIleProAsnGlnGluAsnLeuAlaLysTyrArgG luAsnIle-84 92-AlaAspThrAsnGlyAspAspAspProTyrArgValCysLys-105 107-AlaAlaGlnAspAlaGluIleLeuMet-115 119-ValThrSerGlyGlyGlyGlyThrThrAspLeuAspLysGluSerTyrGlnAsnTyrArgLysSerMetGln GluCysArgLysThrIleThrGluAlaGluAlaAsnLeuProLysLys-158 Hydrophilic Regions - Hopp-Woods 17-GlyGlnGluGlnSerGlnLysAlaAspAlaGlu-27 36-GlnPheAlaAspGluLysGln-42 61-GlyAspPheGluArgPheLeuLys-68 70-GluIleProAsnGlnGluAsnLeuAlaLysTyrArgGluAsnIle-84 94-ThrAsnGlyAspAspAspProTyrArgValCysLys-105 107-AlaAlaGlnAspAlaGluIleLeuMet-115 125-GlyThrThrAspLeuAspLysGluSerTyrGlnAsnTyrArgLysSerMetGlnGluCysArgLysThrIle ThrGluAlaGluAlaAsnLeuProLysLys-158 957 AMPHI Regions - AMPHI H-SerPhePheAlaLeuValPheAla-18 39-AlaThrGluValProLysAsnPro-46 48-AlaPheValAlaLysLeuAlaArgLeuPheArgAsnAla-60 76-AsnLeuAlaGlyThrValAspAsp-83 198-GluAspValTyrGluHisCysLeuGlyCysTyrGlnMet-210 218-TyrArgAspValAlaAsnAspGlu-225 235-SerAsnArgIleAlaSer-240 249-GlnAsnMetArgGluLeuMetProArg-257 335-GluLysGluValArgArgTyrAlaGluAlaAlaAlaArg-367 Antigenic Index - Jameson-Wolf 29-IleAsnProArgTrp-33 35-LeuSerAspThrAlaThrGluValProLysAsnProAsn-47 57-PheArgAsnAlaAspArgAla-63 69-GluSerIleArgThrGluGluAsnLeuAlaGlyThrValAspAspGlyProLeuGlnSerGluLysAspTyr- 92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyLys-118 125-HisIleGlyGluGlyGly-130 136-LeuSerGlnArgSerProGluAlaPheVal-145 149-TyrLeuTyrArgAsnAspArgProPheSer-158 166-ValHisGlyGluAsnTyrGluThrThrGlyGluTyrArgVal-179 182-GlnProAspGlySerVal-187 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgLysGluSerAsnArgIleAlaSer AspSerArgAsnSerValPheTyrGlnAsnMetArgGluLeuMetProArgGlyMetLysAlaAsnSer-263 267-GlyTyrAspAlaAspGlyLeuProGlnLys-276 280-SerPheAspAsnGlyLysLysArgGlnSerPheGluTyrTyrLeuLysAsnGlyAsn-298 309-LeuLysAlaAspGlyValThr-315 329-LeuAspGlyGlyArgIleValArgGluGluLysGlnGlyAspArgLeuProAspPhe-347 352-GluAsnLeuGluLysGluValArgArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArgArgAspLeu SerHis-377 Hydrophilic Regions - Hopp-Woods 38-ThrAlaThrGluValProLysAsnPro-46 57-PheArgAsnAlaAspArgAla-63 69-GluSerIleArgThrGluGluAsnLeu-77 80-ThrValAspAspGlyProLeuGlnSerGluLysAspTyr-92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyLys-118 136-LeuSerGlnArgSerProGlu-142 151-TyrArgAsnAspArgProPhe-157 169-GluAsnTyrGluThrThrGlyGluTyr-177 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgLysGluSerAsnArgIleAlaSer AspSerArgAsn-244 250-AsnMetArgGluLeuMetProArgGlyMetLys-260 268-TyrAspAlaAspGlyLeuPro-274 282-AspAsnGlyLysLysArgGlnSer-289 309-LeuLysAlaAspGlyValThr-315 331-GlyGlyArgIleValArgGluGluLysGlnGlyAspArgLeuPro-345 352-GluAsnLeuGluLysGluValArgArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArgArgAspLeu SerHis-377 958 AMPHI Regions - AMPHI 34-AspAsnProThrAlaGlyGluSerValArgSerValSerGluProIleGln-50 86-ProGluAspTyrThrArgIleValAlaAsp-95 127-TyrAspGlnSerGlyAsp-132 176-GlyArgArgLeuGlnSerValSerArgThrAlaGluMet-188 343-IleSerAspThrLeuGln-348 483-TyrTyrSerLeuAsnArgPhe-489 491-SerGlnGluAlaArgArgVal-497 500-ThrLeuProIleVal-504 521-GlyGluValLeuGlnThrLeuGluProArgLeu-531 541-GlnAsnAspLeuProAsnPheAsp-548 572-AsnThrAlaAsnSerLeuSerAlaAlaValGlnSer-583 616-ValGlyLysLysPro-620 693-AspLysLeuSerGln-697 723-LysLysProIleGlu-727 769-AspLeuSerSerValGlyArgAsnPro-777 Antigenic Index - Jameson-Wolf 28-ValAlaAlaGluGluThrAspAsnProThrAlaGlyGluSerValArgSerValSerGluProIleGln-50 55-SerLeuGlySerThr-59 63-CysSerAsnGluSerGlySerProGluArgThrGluAlaAlaValGlnGlySerGlyGluAlaSerIleProG luAspTyrThrArgIleValAlaAspArgMetGluGlyGlnSerGlnValGlnValArgAlaGluGly-109 Hl-ValValValGluArgAsnArgThrThrLeuAsn-121 123-AspTrpAlaAspTyrAspGlnSerGlyAspThrValThrAlaGlyAspArgPheAlaLeuGlnGlnAspGly ThrLeuIleArgGlyGluThrLeu-154 158-LeuGluGlnGlnThrGlyGluAlaHisAsnValArgMetGluIleGluGlnGlyGlyArgArgLeuGlnSer ValSerArgThrAlaGluMetLeuGlyGluGlyHisTyrLysLeuThrGluThrGlnPheAsnThrCysSerAlaG lyAspAlaGlyTrp-211 216-AlaSerValGluAlaAspArgGluLysGlyIleGly-227 249-PheProLeuAspGlyAsnArgLysSerGlyLeu-259 265-SerAlaGlySerAspGlyVal-271 293-ValIleGlyGluArgGlyAlaValPheAspGlyGlnValArgTyrLeuArgProAspTyrAlaGlyGlnSer Asp-317 321-LeuProHisAspLysLysSerGlyArgAsnAsnArgTyrGlnAla-335 337-TrpGlnHisArgHisAspIleSerAspThrLeu-347 352-AspPheAsnGlnValSerAspSerGlyTyrTyrArgAspPheTyrGlyAsnLysGluIleAlaGlyAsnVal AsnLeuAsnArgArgValTrp-382 384-AspTyrGlyGlyArgAlaAlaGlyGlySerLeu-394 407-AlaAsnGlnSerGlyTyrLysAspLysProTyr-417 425-ValGluTrpArgLysAsnThrGlyArgAla-434 444-ArgPheSerHisAspSerArgGlnAspGlySerArg-455 460-ProAspIleLysTrpAspPheSerAsnSerTrpGly-471 487-AsnArgPheGlySerGlnGluAlaArgArgValSerArg-499 507-AspSerGlyAlaThrPheGluArgAsnThrArgMetPheGly-520 538-AlaLysSerGlnAsnAspLeuProAsnPheAspSerSerGluSerSerPheGly-555 560-PheArgGluAsnLeuTyrTyrGlyAsnAspArgIleAsnThrAlaAsnSer-576 581-ValGlnSerArgIleLeuAspGlyAlaThrGlyGluGluArgPheArgAlaGlyIleGlyGlnLysPheTyr PheLysAspAspAlaValMetLeuAspGlySerValGlyLysLysProArgAsnArgSerAspTrp-626 631-SerGlySerIleGlySer-636 642-SerSerIleHisTyrAsnGlnAsnAspLysArgAlaGluAsn-655 660-AlaSerTyrArgProAlaGlnGlyLysValLeuAsnAlaArgTyrLysTyrGlyArgAsnGluLysIleTyr LeuLysSerAspGlySerTyrPhe-691 693-AspLysLeuSerGln-697 718-TyrGlyPheGluAlaLysLysProIleGlu-727 732-AlaGluTyrLysSerSerCysGlyCysTrp-741 751-ValThrGlyGluAsnThrTyrLysAsn-759 766-GlnLeuLysAspLeuSerSerValGlyArgAsnProAlaAspArgMetAspVal-783 794-LeuSerAlaGlyArgAsnLysArgPro-802 Hydrophilic Regions - Hopp-Woods 28-ValAlaAlaGluGluThrAspAsnProThrAlaGlyGluSerValArgSerValSerGluProIleGln-50 65-AsnGluSerGlySerProGluArgThrGluAlaAlaVal-77 79-GlySerGlyGluAlaSerIleProGluAspTyrThr-90 93-ValAlaAspArgMetGluGlyGlnSer-101 103-ValGlnValArgAlaGluGly-109 lll-ValValValGluArgAsnArgThrThrLeu-120 125-AlaAspTyrAspGlnSerGlyAspThrValThrAlaGlyAspArgPheAlaLeu-142 147-ThrLeuIleArgGlyGluThr-153 160-GlnGlnThrGlyGluAlaHisAsnValArgMetGluIleGluGlnGlyGlyArgArgLeuGlnSerValSer ArgThrAlaGluMetLeuGly-190 192-GlyHisTyrLysLeuThrGlu-198 216-AlaSerValGluAlaAspArgGluLysGlyIleGly-227 250-ProLeuAspGlyAsnArgLysSerGly-258 266-AlaGlySerAspGlyVal-271 294-IleGlyGluArgGlyAlaVal-300 305-ValArgTyrLeuArg-309 323-HisAspLysLysSerGlyArgAsnAsnArgTyrGlnAla-335 337-TrpGlnHisArgHisAspIleSerAsp-345 410-SerGlyTyrLysAspLysProTyr-417 425-ValGluTrpArgLysAsnThrGlyArgAla-434 445-PheSerHisAspSerArgGlnAspGlySerArg-455 490-GlySerGlnGluAlaArgArgValSerArg-499 510-AlaThrPheGluArgAsnThrArg-517 539-LysSerGlnAsnAsp-543 548-AspSerSerGluSer-552 569-AspArgIleAsnThr-573 589-AlaThrGlyGluGluArgPheArgAla-597 604-TyrPheLysAspAspAlaValMet-611 615-SerValGlyLysLysProArgAsnArgSerAsp-625 648-GlnAsnAspLysArgAlaGluAsn-655 662-TyrArgProAlaGln-666 674-TyrLysTyrGlyArgAsnGluLysIleTyrLeuLysSerAspGly-688 720-PheGluAlaLysLysProIleGlu-727 732-AlaGluTyrLysSer-736 766-GlnLeuLysAspLeuSerSerValGlyArgAsnProAlaAspArgMetAspVal-783 795-SerAlaGlyArgAsnLysArgPro-802 959 AMPHI Regions - AMPHI 56-AlaAlaLeuAlaArgValGlyGly-63 Antigenic Index - Jameson-Wolf 24-AlaHisHisAspGlyHisGlyAspAspAspHisGlyHis-36 38-AlaHisGlnHisAsnLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAlaLeu-58 60-ArgValGlyGlyLysIleThrAspIleAspLeuGluHisAspAsnGlyArgProHisTyrAspValGluIleV alLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArgValIleSerSerArgArgAspAsp-108 Hydrophilic Regions - Hopp-Woods 27-AspGlyHisGlyAspAspAspHisGlyHis-36 40-GlnHisAsnLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAlaLeu-58 61-ValGlyGlyLysIleThrAspIleAspLeuGluHisAspAsnGlyArgProHisTyr-79 82-GluIleValLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArg-100 102-IleSerSerArgArgAspAsp-108 960 AMPHI Regions - AMPHI 24-AlaProArgLeuLeuProSerPheThrAspPro-34 39-LeuSerAlaProGlyGlyTyrIleVal-47 58-IleGluLysLeuAlaLysGlnProGluTyrAlaTyrLeuLysGlnLeuGlnValAlaLysAsnValAsn-80 137-PheAlaSerLeuAlaSer-142 154-AspValGlyLysThrLeuLysGluLeuGlyArgSerArgThr-167 189-LeuAlaThrTrpSerGlu-194 230-AsnIleLeuAlaAlaLeuValAsnThrAla-239 245-SerLysIleLysGly-249 257-HisLysIleAlaHisAlaValAlaGlyCysAla-267 280-AlaIleGlyAlaAlaValGlyGluIleValGlyGlu-291 314-11eThrAlaTyrAlaLys-319 338-GlnThrAlaGlnAsnAla-343 345-GluAsnAsnAlaValLysAlaValValThr-354 359-ValTyrLysValAlaArgLysGly-366 387-AsnLeuAlaAspAsnLeuThrThrLeuPheAsp-397 418-AsnArgAlaAsnLysGlyGluAlaAlaGlnLysValLysGluValLeu-433 460-LysGlnLeuAlaGlnIle-465 Antigenic Index - Jameson-Wolf ll-LeuTyrArgArgGlySerValLysProProLeu-21 23-GluAlaProArgLeuLeuProSerPheThrAsp-33 35-ValValProLysLeuSerAlaProGly-43 48-AspIleProLysGlyAsnLeuLysThrGluIleGluLysLeuAlaLysGlnProGlu-66 77-LysAsnValAsnTrp-81 87-AlaTyrAspLysTrpAspTyrLysGlnGluGlyLeuThr-99 150-AsnAsnLysGlyAspValGlyLysThrLeuLysGluLeuGlyArgSerArgThrValLys-169 180-ValSerAsnLysLeuGlyAla-186 193-SerGluThrProTrp-197 218-ValAsnGlyGlySerLeuLysAspAsnLeuGlu-228 239-AlaHisGlyGluAlaAlaSerLysIleLysGlyLeuAsp-251 270-AlaAlaAsnLysGlyLysCysGlnAspGlyAla-280 292-AlaLeuValLysAsnThrAspPheSerAspMetThrProGluGlnLeuAspLeuGluValLysLys-313 329-ThrGlyGlyAspValAsnThr-335 362-ValAlaArgLysGlyLeuLysAsnGlyLysIleAsnValArgAspLeuLysGlnThrLeuLysAspGluGly TyrAsnLeu-388 398-GluThrLeuAspTrpAsnAspAlaLysAla-407 415-ThrGluLeuAsnArgAlaAsnLysGlyGluAlaAlaGlnLysValLysGluValLeuGluLysAsnArgPro TyrIleProAsnLysGlyAlaValPro-447 451-ThrTyrMetLysAsnAsnProPheGlyLysGln-461 465-IleSerGluLysThrThrLeuProThrGlnGlnGlyGlnSer-478 483-LysArgAsnGlnGlyLeuLeuLysThrGlyAspArgPheTyrLeuAspGlyGlnHisLysAsnHisLeu-50 5 507-ValPheAspLysAsnGlyAsnPheLys-515 520-MetAspGlySerLeuAsnGlnMetLysThrGlyAlaAlaLysGlyArgLysLeuAsnLeu-539 Hydrophilic Regions - Hopp-Woods 13-ArgArgGlySerValLys-18 49-IleProLysGlyAsnLeuLysThrGluIleGluLysLeuAlaLysGlnProGlu-66 89-AspLysTrpAspTyrLysGlnGluGlyLeuThr-99 150-AsnAsnLysGlyAspValGlyLysThrLeuLysGluLeuGlyArgSerArgThrValLys-169 221-GlySerLeuLysAspAsnLeuGlu-228 239-AlaHisGlyGluAlaAlaSerLysIleLysGlyLeuAsp-251 270-AlaAlaAsnLysGlyLysCysGlnAsp-278 292-AlaLeuValLysAsnThrAspPheSerAspMetThrProGluGlnLeuAspLeuGluValLysLys-313 362-ValAlaArgLysGlyLeuLysAsnGlyLysIleAsnValArgAspLeuLysGlnThrLeuLysAspGluGly TyrAsn-387 398-GluThrLeuAspTrpAsnAspAlaLysAla-407 416-GluLeuAsnArgAlaAsnLysGlyGluAlaAlaGlnLysValLysGluValLeuGluLysAsnArgPro-43 465-IleSerGluLysThrThrLeu-471 483-LysArgAsnGlnGly-487 499-GlyGlnHisLysAsnHis-504 507-ValPheAspLysAsnGlyAsn-513 522-GlySerLeuAsnGln-526 528-LysThrGlyAlaAlaLysGlyArgLysLeuAsnLeu-539 961-2 AMPHI Regions - AMPHI 6-PheProSerLysVal-10 13-ThrAlaIleLeuAlaThrPheCysSerGly-22 46-AsnGlyGlnGluIleAsnGlyPheLysAlaGlyGluThrIleTyrAspIle-62 90-LysValValThrAsnLeuThrLysThrVal-99 118-GluLysLeuThrThr-122 138-LeuAspGluThrThrAsnAlaLeuAsnLysLeuGlyGluAsnIleThrThrPheAla-156 170-LeuGluAlaValAlaAspThrValAspLysHisAlaGluAlaPheAsnAspIleAlaAspSerLeuAsp-19 2 200-GluAlaValLysThrAlaAsnGluAlaLysGlnThrAlaGlu-213 273-AlaArgIleAspSerLeuAspLysAsnValAlaAsnLeuArgLysGluThrArgGlnGlyLeu-293 300-SerGlyLeuPheGlnProTyrAsnVal-308 Antigenic Index - Jameson-Wolf 27-ThrSerAspAspAspValLysLysAlaAla-36 45-AsnAsnGlyGlnGluIleAsnGlyPheLysAlaGlyGluThr-58 60-TyrAspIleGlyGluAspGlyThrIleThrGlnLysAspAlaThrAlaAlaAspValGluAlaAspAspPheL ys-84 98-ThrValAsnGluAsnLysGlnAsnValAspAlaLysValLysAlaAlaGluSerGluIleGluLysLeuThrT hrLysLeuAlaAspThrAspAlaAlaLeuAlaAspThrAspAlaAlaLeuAspGluThrThrAsnAlaLeuAsnLy sLeuGlyGluAsnIleThr-153 155-PheAlaGluGluThrLysThrAsnIleValLysIleAspGluLysLeuGluAlaValAlaAspThrValAsp LysHisAlaGluAlaPheAsnAspIleAlaAspSerLeuAspGluThrAsnThrLysAlaAspGluAlaValLysT hrAlaAsnGluAlaLysGlnThrAlaGluGluThrLysGlnAsnValAspAlaLysValLysAlaAlaGluThrAl aAlaGlyLysAlaGluAlaAlaAla-237 239-ThrAlaAsnThrAlaAlaAspLysAlaGluAlaValAla-251 253-LysValThrAspIleLysAlaAspIleAlaThrAsnLysAlaAspIleAlaLysAsnSerAlaArgIleAsp SerLeuAspLysAsnValAlaAsnLeuArgLysGluThrArgGlnGlyLeuAla-294 317-ValGlyGlyTyrLysSerGluSer-324 330-ThrGlyPheArgPhe-334 348-ThrSerSerGlySerSerAla-354 Hydrophilic Regions - Hopp-Woods 27-ThrSerAspAspAspValLysLysAlaAla-36 54-LysAlaGlyGluThr-58 62-IleGlyGluAspGlyThrIleThrGlnLysAspAlaThrAlaAlaAspValGluAlaAspAspPheLys-84 98-ThrValAsnGluAsnLysGlnAsnValAspAlaLysValLysAlaAlaGluSerGluIleGluLysLeuThrT hrLysLeuAlaAspThrAspAlaAlaLeuAlaAspThrAspAlaAlaLeuAspGluThrThrAsnAla-144 155-PheAlaGluGluThrLysThrAsnIleValLysIleAspGluLysLeuGluAlaValAlaAspThrValAsp LysHisAlaGluAlaPheAsnAspIleAlaAspSerLeuAspGluThrAsnThrLysAlaAspGluAlaValLysT hrAlaAsnGluAlaLysGlnThrAlaGluGluThrLysGlnAsnValAspAlaLysValLysAlaAlaGluThrAl aAlaGlyLysAlaGluAlaAlaAla-237 242-ThrAlaAlaAspLysAlaGluAlaValAla-251 253-LysValThrAspIleLysAlaAspIleAlaThrAsnLysAlaAspIleAlaLysAsnSerAlaArgIleAsp SerLeuAspLysAsnValAlaAsnLeuArgLysGluThrArgGlnGlyLeuAla-294 320-TyrLysSerGluSer-324 972-2 AMPHI Regions - AMPHI 15-SerSerGluArgMetSerGluValGluTyrPheSerHis-27 83-ArgLysLeuGluGluIleLeuGly-90 100-ArgGlyAsnLysPheTyrGluSerMetTyrArgLeu-111 154-LeuAspAspSerIleArg-159 226-PheValArgValTyrGluLysGly-233 275-IleCysArgLysPheLysAsnMetProValPro-285 308-AsnAlaValGlyLysLeuValAsnPhe-316 326-GluIleValGluSerLeuLysAla-333 336-GlyPheProLysGlyLeuGlu-342 348-LeuGluMetLeuArgAspGlyLeuLys-356 382-AsnSerAspLysPheAspArg-388 Antigenic Index - Jameson-Wolf l-LeuThrAsnArgGlyGlyAlaLysLeuLysThrAsnSerLysSerSerGluArgMetSerGlu-21 29-IleSerAspGlyLysGlyLysLeuLeuGluIleProGlnArgArgGlyLysGlnAspGlyVal-49 62-ThrLeuLeuLysValSerGly-68 83-ArgLysLeuGluGlu-87 93-IleThrArgLysCysLysSerArgGlyAsnLysPheTyrGlu-106 108-MetTyrArgLeuGlySerAspAspValAspTyrGly-119 122-HisPheGlyGlyGlnArgAsnThrVal-130 134-LeuLysGlyThrGlyCys-139 152-GlnPheLeuAspAspSerIleArgThrArgIleThrArg-164 172-PheAspGlyGluTyrThrProAspGlnAlaLeuLeuAspHisAspAsnGlyPhePheAspAsnSerAsnGln ArgProLysSerGluThrIleGly-203 205-AlaTrpArgAsnGluAspGlySerGlyLys-214 217-TyrValGlyArgLysLysAsnSerArgPhe-226 228-ArgValTyrGluLysGlyArgGlnLeuGlyAspLysGluSerLysTrpVal-244 251-AsnTyrGlyAspIleGluIle-257 263-IleAsnGlnGlySer-267 275-IleCysArgLysPheLysAsnMetProValProGluArgPheAspGlnArgLysLysLysLeu-295 321-GlyPheAspAsnSerGluIleValGluSerLeuLysAlaAspSerGlyPheProLysGlyLeuGluProGlu LysTyrAla-347 350-MetLeuArgAspGlyLeuLys-356 361-HisGluGlnProAspIleAspLeuGluIleGluLeuAspGlu-374 380-PheLysAsnSerAspLysPheAspArgGluLysArgLeuPheSerProAspTyrAspValGluLysGluArg LysTyrGlnGluTyrLeu-409 417-ValAspTyrAspTyrPhe-422 Hydrophilic Regions - Hopp-Woods l-LeuThrAsnArgGlyGlyAlaLysLeuLysThrAsnSerLysSerSerGluArgMetSerGlu-21 30-SerAspGlyLysGlyLysLeuLeuGluIleProGlnArgArgGlyLysGlnAspGlyVal-49 83-ArgLysLeuGluGlu-87 93-IleThrArgLysCysLysSerArgGlyAsnLysPheTyr-105 lll-LeuGlySerAspAspValAspTyrGly-119 134-LeuLysGlyThrGly-138 152-GlnPheLeuAspAspSerIleArgThrArgIleThrArg-164 181-AlaLeuLeuAspHisAspAsnGlyPhe-189 193-SerAsnGlnArgProLysSerGluThrIle-202 206-TrpArgAsnGluAspGlySerGly-213 219-GlyArgLysLysAsnSerArgPhe-226 228-ArgValTyrGluLysGlyArgGlnLeuGlyAspLysGluSerLysTrpVal-244 277-ArgLysPheLysAsn-281 283-ProValProGluArgPheAspGlnArgLysLysLysLeu-295 321-GlyPheAspAsnSerGluIleValGluSerLeuLysAlaAspSerGlyPhe-337 339-LysGlyLeuGluProGluLysTyrAla-347 350-MetLeuArgAspGlyLeuLys-356 362-GluGlnProAspIleAspLeuGluIleGluLeuAspGlu-374 381-LysAsnSerAspLysPheAspArgGluLysArgLeuPhe-393 396-AspTyrAspValGluLysGluArgLysTyrGlnGluTyrLeu-409 973-2 AMPHI Regions - AMPHI 12-GluArgLeuIleAlaArgLeuAlaArgGluProAspSerAlaGluAspValLeuAsnLeuLeuArgGlnAla- 35 44-AspThrLeuLeuArgLeuGluLysValLeuAspPhe-55 77-AspSerIleGluArgIleThrAlaTyr-85 112-AspLeuLeuLysTyrMet-117 143-AlaLeuLeuLysGluPheArgGluGln-151 171-PheGluAspIleIleGluGlnIleValGlyGluIleGluAsp-184 194-AsnIleHisAlaVal-198 208-AlaThrGluIleGluAspIleAsnThrPhe-217 235-IleGlnGluLeuGly-239 Antigenic Index - Jameson-Wolf 1-MetAspGlyAlaGlnProLysThrAsnPhe-lO 18-LeuAlaArgGluProAspSerAlaGluAspVal-28 34-GlnAlaHisGluGlnGluValPheAspAlaAspThr-45 47-LeuArgLeuGluLysValLeuAsp-54 56-SerAspLeuGluValArgAspAlaMetIleThrArgSerArgMetAsnValLeuLysGluAsnAspSe IleG luArg-81 96-ValIleGlyGluAspLysAspGluVal-104 118-PheAsnProGluGlnPheHis-124 136-ProGluGlyLysSer-140 146-LysGluPheArgGluGlnArgAsnHis-154 159-IleAspGluTyrGlyGlyThrSerGly-167 178-IleValGlyGluIleGluAspGluPheAspGluAspAspSerAlaAspAsn-194 199-SerSerGluArgTrpArg-204 209-ThrGluIleGluAspIleAsn-215 218-PheGlyThrGluTyrSerSerGluGluAlaAspThr-229 239-GlyHisLeuProValArgGlyGluLysValLeu-249 258-AlaArgAlaAspAsnArgArgLeuHis-266 Hydrophilic Regions - Hopp-Woods l-MetAspGlyAlaGlnProLys-7 18-LeuAlaArgGluProAspSerAlaGluAspVal-28 34-GlnAlaHisGluGlnGluValPheAsp-42 47-LeuArgLeuGluLysValLeuAsp-54 56-SerAspLeuGluValArgAspAlaMetIleThrArgSerArgMetAsnValLeuLysGluAsnAspSerIleG luArg-81 96-ValIleGlyGluAspLysAspGluVal-104 136-ProGluGlyLysSer-140 146-LysGluPheArgGluGlnArgAsn-153 178-IleValGlyGluIleGluAspGluPheAspGluAspAspSerAlaAspAsn-194 199-SerSerGluArgTrpArg-204 209-ThrGluIleGluAsp-213 222-TyrSerSerGluGluAlaAspThr-229 243-ValArgGlyGluLysValLeu-249 258-AlaArgAlaAspAsnArgArgLeuHis-266 981-2 AMPHI Regions - AMPHI 33-AlaAsnProAspLysValTyrArgValAlaSer-43 48-AlaProPheGluSerLeuAsp-54 68-AsnAlaMetAlaLys-72 134-LysValSerSerSerGluAspLeuLysAsnMetAsnLysValGlyValVal-150 169-LysIleAlaArgPheGlu-174 183-LeuGluAsnGlyGlyLeuAspSerValVal-192 199-AlaAsnTyrValLysAsnAsnPro-206 209-GlyMetAspPheValThrLeuPro-216 235-ValLysMetLeuAsnAspAlaLeuGluLysValArgGluSerGlyGluTyr-251 Antigenic Index - Jameson-Wolf 21-CysGlyGlyGlnGlyLysAspThrAlaAla-30 33-AlaAsnProAspLysValTyrArg-40 51-GluSerLeuAspSerLysGlyAsnValGluGlyPheAsp-63 78-IleGluPheLysHisGlnProTrpAspSer-87 92-LeuAsnAsnGlyAspAlaAspVal-99 106-IleThrAspAspArgLysGlnSerMetAspPheSerAspProTyrPhe-121 129-ValProLysGlyLysLysValSerSerSerGluAspLeuLysAsnMetAsnLys-146 162-LeuLeuGlyAsnAspAsnProLysIleAlaArg-172 181-LysGluLeuGluAsnGlyGlyLeuAspSerValValSerAspSerAla-196 203-LysAsnAsnProAlaLysGlyMetAspPhe-212 216-ProAspPheThrThr-220 227-ValArgLysGlyAspGluAlaThrVal-235 237-MetLeuAsnAspAlaLeuGluLysValArgGluSerGlyGluTyrAspLysIleTyr-255 259-PheAlaLysGluAspGlyGlnAlaAlaLys-268 Hydrophilic Regions - Hopp-Woods 23-GlyGlnGlyLysAspThrAlaAla-30 33-AlaAsnProAspLysValTyrArg-40 51-GluSerLeuAspSerLysGlyAsnValGluGlyPheAsp-63 93-AsnAsnGlyAspAlaAspVal-99 106-IleThrAspAspArgLysGlnSerMetAspPheSer-117 130-ProLysGlyLysLysValSerSerSerGluAspLeuLysAsnMetAsn-145 166-AspAsnProLysIleAlaArg-172 181-LysGluLeuGluAsnGlyGlyLeu-188 205-AsnProAlaLysGlyMetAsp-211 227-ValArgLysGlyAspGluAlaThrVal-235 237-MetLeuAsnAspAlaLeuGluLysValArgGluSerGlyGluTyrAspLysIleTyr-255 259-PheAlaLysGluAspGlyGlnAlaAlaLys-268 982 AMPHI Regions - AMPHI 12-ValArgGlnLysMetValAsnGlyValAsnIleLeuAlaAsnAlaVal-27 71-AlaGlnMetValLysGluValAlaSerLysThr-81 100-ValAlaGluGlyMetLysTyr-106 115-AspLeuLysArgGlyIleAspLysAlaValAlaAlaLeuValAspGluLeuLysAsnIleAlaLysProCys AspThrSerLysGluIleAlaGlnValGlySer-149 160-AlaIleIleAlaGluAlaMetGluLysValGly-170 185-AsnGluLeuAspValValGluGlyMet-193 209-GluLysGlnIleAlaAla-214 227-IleSerAsnIleArgAspLeuLeuProValLeuGluGlnValAlaLysAla-243 265-AsnAsnl1eArgGlyIleLeuLysThrValAla-275 313-ThrLeuAspAspLeuGlyGlnAlaLysArgIle-323 331-ThrIleIleAspGlyPheGlyAspAlaAla-340 367-GluArgValAlaLysLeuAlaGlyGlyVal-376 426-LeuGluAsnLeuHisThr-431 444-LeuArgAlaValGluSerProLeuArgGlnIleValAlaAsnAla-458 484-GluTyrGlyAspMetIleGluMet-491 500-ThrArgSerAlaLeu-504 Antigenic Index - Jameson-Wolf l-MetAlaAlaLysAspValGlnPhe-8 10-AsnGluValArgGlnLysMetValAsn-18 30-ThrLeuGlyProLysGlyArgAsnValValVal-40 43-AlaPheGlyGlyProHisIleThrLysAspGlyValThrValAlaLysGluIleGluLeuLysAspLysPheG luAsnMetGly-70 73-MetValLysGluValAlaSerLysThrAsnAspValAlaGlyAspGlyThrThr-90 112-AsnProThrAspLeuLysArgGlyIleAspLysAlaVal-124 129-AspGluLeuLysAsnIleAlaLysProCysAspThrSerLysGluIleAla-145 150-IleSerAlaAsnSerAspGluGlnVal-158 164-GluAlaMetGluLysValGlyLysGluGlyValIleThrValGluAspGlyLysSerLeuGluAsnGluLeu AspVal-189 193-MetGlnPheAspArgGlyTyr-199 207-AspAlaGluLysGlnIleAla-213 223-PheAspLysLysIleSerAsnIleArgAsp-232 239-GlnValAlaLysAlaSerArg-245 252-GluAspValGluGlyGluAla-258 266-AsnIleArgGlyIleLeu-271 278-AlaProGlyPheGlyAspArgArgLysAlaMetLeu-289 303-GluGluValGlyLeuSerLeuGluLysAlaThrLeuAspAspLeuGlyGlnAlaLysArgIleGluIleGly LysGluAsnThrThr-331 334-AspGlyPheGlyAspAlaAlaGlnIleGluAlaArgValAlaGluIleArgGlnGlnIleGluThrAlaThr SerAspTyrAspLysGluLysLeuGlnGluArgValAlaLysLeuAlaGly-374 385-ThrGluValGluMetLysGluLysLysAspArgValGluAspAlaLeuHis-401 405-AlaAlaValGluGluGlyVal-411 421-ArgAlaArgAlaAlaLeu-426 430-HisThrGlyAsnAlaAspGlnAspAlaGlyVal-440 446-AlaValGluSerProLeuArg-452 455-ValAlaAsnAlaGlyGlyGluProSerVal-464 469-ValLeuGluGlyLysGlyAsnTyrGlyTyr-478 480-AlaGlySerGlyGluTyrGlyAspMetIleGlu-490 495-AspProAlaLysValThrArgSerAlaLeu-504 523-GluIleProGluAspLysProAlaValProAspMetGlyGly-536 Hydrophilic Regions - Hopp-Woods l-MetAlaAlaLysAspValGlnPhe-8 10-AsnGluValArgGlnLysMet-16 33-ProLysGlyArgAsnValValVal-40 48-HisIleThrLysAspGlyValThrValAlaLysGluIleGluLeuLysAspLysPheGluAsn-68 73-MetValLysGluValAlaSerLysThrAsnAspValAlaGlyAspGlyThrThr-90 114-ThrAspLeuLysArgGlyIleAspLysAlaVal-124 129-AspGluLeuLysAsnIleAlaLysProCysAspThrSerLysGluIleAla-145 152-AlaAsnSerAspGluGlnVal-158 164-GluAlaMetGluLysValGlyLysGluGlyValIleThrValGluAspGlyLysSerLeuGluAsnGluLeu AspVal-189 207-AspAlaGluLysGlnIleAla-213 223-PheAspLysLysIleSerAsnlleArgAsp-232 239-GlnValAlaLysAlaSerArg-245 252-GluAspValGluGlyGluAla-258 280-GlyPheGlyAspArgArgLysAlaMetLeu-289 303-GluGluValGlyLeuSerLeuGluLysAlaThrLeuAspAspLeuGlyGlnAlaLysArgIleGluIleGly LysGluAsnThrThr-331 340-AlaGlnIleGluAlaArgValAlaGluIleArgGlnGlnIleGluThrAlaThrSerAspTyrAspLysGlu LysLeuGlnGluArgValAlaLys-371 385-ThrGluValGluMetLysGluLysLysAspArgValGluAspAlaLeuHis-401 405-AlaAlaValGluGluGlyVal-411 421-ArgAlaArgAlaAlaLeu-426 433 -AsnAlaAspGlnAspAla-438 446-AlaValGluSerProLeu-451 458-AlaGlyGlyGluPro-462 469-ValLeuGluGlyLysGly-474 481-GlySerGlyGluTyrGlyAsp-487 495-AspProAlaLysValThrArg-501 523-GluIleProGluAspLysProAlaVal-531 986-2 AMPHI Regions - AMPHI 6-GlnTyrLeuAlaLeuAla-ll 18-LeuAlaGlyCysAspLysAlaGly-25 36-SerPheValGluArgIleGluHis-43 55-ProAspPheAlaGlnLeuValGln-62 99-PheTyrGluPhePheLysArgLeuValProAsnMetProGluIleProGln-115 145-ThrGlyMetGlySerIle-150 162-AlaLysLeuIleGlySerAspVal-169 189-IleGlyAsnProLysAspLeuLysProGly-198 200-TrpValAlaAlaIleGly-205 287-AlaGluGlnLeuLysAsnThrGlyLysVal-296 393-AlaAlaGluHisIleGlyAlaSer-400 471-ArgLysAlaMetAspLysAla-477 Antigenic Index - Jameson-Wolf l-ValPheLysLysTyr-5 20-GlyCysAspLysAlaGly-25 29-GlyAlaAspLysLysGluAlaSerPheValGluArgIleGluHisThrLysAspAspGlySerVal-50 61-ValGlnSerGluGlyProAla-67 75-ProAlaProArgThrGlnAsnGlySerGlyAsnAlaGluAsnAspSerAspProIleAlaAspAsnAspProP he-99 104-LysArgLeuValProAsnMetProGluIleProGlnGluGluAlaAspAspGlyGlyLeu-123 130-IleIleSerLysAspGlyTyr-136 154-LeuAsnAspLysArgGluTyrThr-161 165-IleGlySerAspValGlnSerAspValAla-174 179-AspAlaThrGluGluLeuPro-185 189-1leGlyAsnProLysAspLeuLysProGlyGlu-199 208-PheGlyPheAspAsnSerVal-214 219-ValSerAlaLysGlyArgSerLeuProAsnGluSerTyr-231 242-AsnProGlyAsnSerGlyGlyPro-249 265-TyrSerArgSerGlyGly-270 288-GluGlnLeuLysAsnThrGlyLysValGlnArgGlyGlnLeu-301 316-PheGlyLeuAspLysAlaGlyGly-323 330-LeuProGlySerProAlaGluArgAlaGlyLeuGlnAlaGlyAsp-344 349-LeuAspGlyGlyGluIleArgSerSerGlyAspLeu-360 368-ThrProGlyLysGluValSer-374 378-TrpArgLysGlyGluGluIleThrIle-386 397-IleGlyAlaSerSerLysThrAspGluAlaProTyrThrGluGlnGlnSerGlyThrPhe-416 427-ThrHisThrAspSerSerGlyGly-434 440-ArgValSerAspAlaAlaGluArgAlaGlyLeuArgArgGlyAspGluIleLeu-457 463-ProValAsnAspGluAlaGlyPheArgLysAlaMetAspLysAlaGlyLysAsnVal-481 486-MetArgArgGlyAsnThr-491 Hydrophilic Regions - Hopp-Woods 20-GlyCysAspLysAlaGly-25 29-GlyAlaAspLysLysGluAlaSerPheValGluArgIleGluHisThrLysAspAspGlySer-49 75-ProAlaProArgThrGlnAsnGlySerGlyAsnAlaGluAsnAspSerAspProIleAlaAspAsnAspPro- 98 lll-ProGluIleProGlnGluGluAlaAspAspGlyGly-122 131-IleSerLysAspGly-135 154-LeuAsnAspLysArgGluTyrThr-161 179-AspAlaThrGluGluLeuPro-185 190-GlyAsnProLysAspLeuLysPro-197 221-AlaLysGlyArgSerLeuPro-227 288-GluGlnLeuLysAsnThrGlyLysValGlnArgGlyGln-300 317-GlyLeuAspLysAlaGly-322 333-SerProAlaGluArgAlaGlyLeuGln-341 350-AspGlyGlyGluIleArgSerSerGlyAsp-359 368-ThrProGlyLysGluValSer-374 379-ArgLysGlyGluGluIleThrIle-386 397-IleGlyAlaSerSerLysThrAspGluAlaProTyrThrGluGlnGlnSer-413 428-HisThrAspSerSerGly-433 440-ArgValSerAspAlaAlaGluArgAlaGlyLeuArgArgGlyAspGluIleLeu-457 463-ProValAsnAspGluAlaGlyPheArgLysAlaMetAspLysAlaGlyLys-479 987 AMPHI Regions - AMPHI 17-CysSerΞerTrpLeu-21 33-PheAsnThrSerLysProValArgLeuAspAsnIleLeuGlnIle-47 65-ProHisGluAlaPhe-69 144-AsnProPheValLeuArgLysTrpArgAlaLeuGlyTyrLeuThrAspPheProArgLeuAsnArg-165 187-GlyAspGluTyrPheLysVal-193 202-LeuAspIleLeuAlaThr-207 211-ValGlyGluValSerHisAspPheAspArgTyrTrpAla-223 230-AlaThrArgIleIleArgSerGlyAspIleGlyLysGlyLeuGlnAla-245 290-AspAspProAlaLysGlyLeuAspArg-298 307-GlyArgLeuGlnAspAlaLeuLysGlnPro-316 333-GlyThrAspAlaLeuAlaLysLeuValGlnAsp-343 355-GlnAlaThrAspValAlaAla-361 443-LysIleAlaGluGlnMetGluArgThrLeu-452 486-ProGluAlaLysLeuTrpLysArgIleAlaAlaLysIleLeuSerLeuLeuProIleGluGlyLeu-507 Antigenic Index - Jameson-Wolf l-MetLysThrArgSer-5 23-ProLeuGluGluArgThrGluSerArgHisPheAsnThrSerLysProValArgLeu-41 49-HisThrProHisThrAsnGlyLeuSer-57 77-GluSerAlaGluHisSerLeu-83 90-TrpArgAsnAspIleSerGlyArgLeu-98 107-AlaGluArgGlyValArg-112 115-LeuLeuLeuAspAspAsnAsnThrArgGlyLeuAsp-126 134-SerHisProAsnIleGluValArgLeu-142 159-AspPheProArgLeuAsnArgArgMetHisAsnLysSerPheThrAlaAspAsnArgAla-178 182-GlyGlyArgAsnIleGlyAspGluTyrPheLysValGlyGluAspThrVal-198 214-ValSerHisAspPheAspArgTyrTrp-222 225-HisSerAlaHisAsn-229 232-ArgIleIleArgSerGlyAspIleGlyLysGlyLeu-243 247-GlyTyrAsnAspGluThrSerArg-254 259-ArgTyrArgGluThrValGlu-265 267-SerProLeuTyrGln-271 282-SerValArgThrArgLeuIleSerAspAspProAlaLysGlyLeuAspArgAspArgArgLysProProIle -305 308-ArgLeuGlnAspAlaLeuLysGlnProGluLysSer-319 328-ValProThrLysSerGlyThrAspAlaLeu-337 340-LeuValGlnAspGlyIleAsp-346 367-ValLysTyrArgLysProLeuLeu-374 391-AlaThrLysAspLysGlyLeuThrGlySerSer-401 412-ValAspGlyLysArgIlePhe-418 422-PheAsnLeuAspProArgSerAlaArgLeuAsnThr-433 440-GluSerProLysIleAlaGluGlnMetGluArgThrLeuAlaAspThrThrPro-457 463-ValThrLeuAspArgHisAsnArgLeuGlnTrpHisAspProAlaThrArgLysThrTyrProAsnGluPro GluAlaLysLeuTrpLys-492 Hydrophilic Regions - Hopp-Woods l-MetLysThrArgSer-5 24-LeuGluGluArgThrGluSerArgHisPheAsnThr-35 37-LysProValArgLeu-41 77-GluSerAlaGluHisSerLeu-83 107-AlaGluArgGlyValArg-112 115-LeuLeuLeuAspAspAsnAsnThrArgGlyLeuAsp-126 161-ProArgLeuAsnArgArgMetHisAsn-169 172-PheThrAlaAspAsnArgAla-178 189-GluTyrPheLysValGlyGluAspThrVal-198 214-ValSerHisAspPheAspArg-220 232-ArgIleIleArgSerGlyAspIleGlyLys-241 248-TyrAsnAspGluThrSerArg-254 259-ArgTyrArgGluThrValGlu-265 282-SerValArgThrArgLeuIleSerAspAspProAlaLysGlyLeuAspArgAspArgArgLysProProIle -305 308-ArgLeuGlnAspAlaLeuLysGlnProGluLysSer-319 331-LysSerGlyThrAspAlaLeu-337 340-LeuValGlnAspGlyIleAsp-346 367-ValLysTyrArgLysProLeuLeu-374 391-AlaThrLysAspLysGlyLeuThr-398 424-LeuAspProArgSerAlaArgLeuAsnThr-433 440-GluSerProLysIleAlaGluGlnMetGluArgThrLeuAla-453 464-ThrLeuAspArgHisAsnArg-470 476-ProAlaThrArgLysThrTyrProAsnGluProGluAlaLysLeuTrpLys-492 988-2 AMPHI Regions - AMPHI 45-SerLysIleGluSerLeuAlaArg-52 125-GlnMetArgGlyIle-129 154-AspIleValGluArgAlaGlnSerLysVal-163 221-AlaLysIleIleGluValLeuGlyAspTyrAlaAsp-232 248-HisGlnPheSerGluAlaCysAlaLysAlaAlaLysLysIle-261 288-ThrAlaArgAspPheAspAsp-294 299-GluLysValGlyArgAsnTyr-305 310-AlaIleAlaAspValSerHisTyrValArgProAspAspValIleAsp-325 348-AsnLeuSerAsnGly-352 396-AsnGlnValTrpLysTrpIleSerAspGlyIleAspHisPro-409 411-LysAlaGlnIleAspThrLeuTyrLysLeuPheLysIleLeuGlnLys-426 494-LeuGlyProThrProGluLysLeuAlaThrLeu-504 526-TyrAlaAlaLeuValGluGlnPheLys-534 544-ValMetMetLeuArgSerMetGlnGlnAla-553 569-AlaTyrAlaHisPheThrSerProIleArgArgTyrProAspLeuThrValHisArgAlaIleLysAlaVal Leu-593 619-AspAspAlaSerArgAspValGluAsnTrpLeuLys-630 646-IleSerGlyMetThrSerPheGlyIlePheValThrLeu-658 662-HisIleAspGlyLeuValHisIleSerAspLeuGlyGlu-674 Antigenic Index - Jameson-Wolf 1-MetAsnLysAsnl1eLys-6 8-LeuAsnLeuArgGluLysAspProPheLeuSerArgGluLysGlnArgTyrGluHisProLeuProSerArgGl uTrpIle-34 37-LeuLeuGluArgLysGlyValProSerLysIleGluSerLeuAlaArgGluLeuSerIleThrGluAspGluT yrValPhePheGluArgArgLeuLysAlaMetAlaArgAspGlyGln-76 79-IleAsnArgArgGlyAlaVal-85 87-AlaAlaAspLysLeuAspLeuValLysCysArgValGluAlaHisLysAspGlyPhe-105 111-LeuThrProAlaLysAspGlyAsp-118 124-ArgGlnMetArgGly-128 138-ArgProAlaGlyMetAspArgArgGlyArgArgGluGlyThrVal-152 155-IleValGluArgAlaGlnSerLysValVal-164 168-TyrMetAspArgGlyValAla-174 176-LeuGluProGluAspLysArgLeuAsnGln-185 189-LeuGluProAspGlyValAlaArgPheLysProGluSerGlyGln-203 210-GluValTyrProGluGlnAsnArgProAlaVal-220 227-LeuGlyAspTyrAlaAspSerGlyMetGluIle-237 239-IleAlaValArgLysHisHisLeu-246 253-AlaCysAlaLysAlaAlaLysLysIleProValHisValArgLysSerAspLeuLysGlyArgValAspLeu ArgAsp-278 283-ThrIleAspGlyGluThrAlaArgAspPheAspAsp-294 299-GluLysValGlyArgAsnTyrArg-306 316-HisTyrValArgProAspAspValIleAspAlaAspAlaGlnGluArgSerThrSer-334 337-PheProArgArgVal-341 345-LeuProGluAsnLeuSerAsnGly-352 356-LeuAsnProAspValGluArgLeu-363 374-AlaGlyAsnIleLysGluTyrArgPhe-382 402-IleSerAspGlyIleAspHisProTyrLysAlaGlnIle-414 424-LeuGlnLysLysArgPheGluArgGlyAlaValGluPheGluSerValGlu-440 443-MetIlePheAspAspAsnGlyLysIleGluLys-453 458-ValArgAsnAspAlaHisLysLeuIleGlu-467 482-LeuLysAsnLysHisThrAla-488 493-HisLeuGlyProThrProGluLysLeuAlaThrLeuArgGluGlnLeu-508 516-GlyGlyGlyAspAsnProSerProLysAspTyr-526 532-GlnPheLysGlyArgProAspAlaGluLeu-541 556-GluProHisCysAspGlyHis-562 575-SerProIleArgArgTyrProAspLeuThrVal-585 597-ThrTyrThrProLysLysSerTrp-604 613-PheCysGluArgArgAlaAspAspAlaSerArgAspValGluAsn-627 633-TyrMetArgAspLysValGlyGluValPheGluGlyLysIleSerGly-648 670-SerAspLeuGlyGluAspTyrPheAsnPheArgPro-681 683-IleMetAlaIleGluGlyGluArgSerGlyIleArgPheAsnMetGlyAspArgValAlaValArgValAla ArgAlaAspLeuAspAspGlyLysIle-715 722-GlyGlySerGlyArgGlyArgLysValLysSerSerAlaSerAlaLysProAlaGlyThrAlaGlyLysGly LysProLysThrAlaAlaGluLysLysThrAlaArgGlyGlyLysValArgGlyArgGlyAlaSerAlaAlaAlaG luSerArgLysLysAlaLysLysProValProIleLysValLysLysArgLysGlyLysSer-791 Hydrophilic Regions - Hopp-Woods 1-MetAsnLysAsnl1eLys-6 8-LeuAsnLeuArgGluLysAspProPheLeuSerArgGluLysGlnArgTyrGluHis-26 37-LeuLeuGluArgLysGlyValProSerLysIleGluSerLeuAlaArgGluLeuSerIleThrGluAspGluT yrValPhePheGluArgArgLeuLysAlaMetAlaArgAspGlyGln-76 79-IleAsnArgArgGlyAla-84 87-AlaAlaAspLysLeuAspLeuValLysCysArgValGluAlaHisLysAspGlyPhe-105 113-ProAlaLysAspGlyAsp-118 140-AlaGlyMetAspArgArgGlyArgArgGluGlyThrVal-152 155-IleValGluArgAlaGlnSerLysValVal-164 176-LeuGluProGluAspLysArgLeuAsn-184 189-LeuGluProAspGlyValAlaArgPheLysProGluSerGly-202 210-GluValTyrProGluGlnAsnArgProAlaVal-220 230-TyrAlaAspSerGlyMetGluIle-237 239-IleAlaValArgLysHisHis-245 253-AlaCysAlaLysAlaAlaLysLysIleProValHisValArgLysSerAspLeuLysGlyArgValAspLeu ArgAsp-278 284-IleAspGlyGluThrAlaArgAspPheAspAsp-294 299-GluLysValGlyArgAsnTyr-305 318-ValArgProAspAspValIleAspAlaAspAlaGlnGluArgSerThr-333 358-ProAspValGluArg-362 376-AsnIleLysGluTyrArg-381 405-GlyIleAspHisProTyr-410 424-LeuGlnLysLysArgPheGluArgGlyAlaValGluPheGluSerValGlu-440 443-MetIlePheAspAspAsnGlyLysIleGluLys-453 458-ValArgAsnAspAlaHisLysLeuIleGlu-467 496-ProThrProGluLysLeuAlaThrLeuArgGluGlnLeu-508 517-GlyGlyAspAsnProSerProLysAspTyr-526 532-GlnPheLysGlyArgProAspAlaGluLeu-541 576-ProIleArgArgTyrProAsp-582 598-TyrThrProLysLysSerTrp-604 613-PheCysGluArgArgAlaAspAspAlaSerArgAspValGluAsn-627 633-TyrMetArgAspLysValGlyGluValPheGluGlyLysIle-646 683-IleMetAlaIleGluGlyGluArgSerGlyIle-693 696-AsnMetGlyAspArgValAlaValArgValAlaArgAlaAspLeuAspAspGlyLysIle-715 723-GlySerGlyArgGlyArgLysValLysSerSerAlaSerAlaLysProAlaGlyThrAlaGlyLysGlyLys ProLysThrAlaAlaGluLysLysThrAlaArgGlyGlyLysValArgGlyArgGlyAlaSerAlaAlaAlaGluS erArgLysLysAlaLysLysProValProIleLysValLysLysArgLysGlyLysSer-791 989 AMPHI Regions - AMPHI 58-AlaGlyLeuThrLysLeu-63 85-SerAlaThrAspPhe-89 98-LysSerGlyLysIleThr-103 109-ProHisIleTyrGlyAla-114 183-GluLeuArgLysTyrAlaAsp-189 205-LysProAsnGlyValAlaGluAla-212 273-AlaMetTrpSerThr-277 301-SerValHisGlyMetTyrLysValSer-309 320-TrpThrArgHisSerArg-325 364-SerTyrGlnIleSerGluProLeu-371 450-PheLysAsnHisAlaAsp-455 Antigenic Index - Jameson-Wolf 46-GluAlaAlaAspAlaSer-51 57-ProAlaGlyLeuThrLysLeuAspSerSerGlnIle-68 81-TyrGluAlaAspSerAlaThrAspPheThr-90 95-GlnGlySerLysSerGlyLysIleThrLysThrThr-106 116-LysValAsnAspAsnLeuThr-122 132-GlySerAlaThrGluTyrGluLysAspSerValLeu-143 146-AsnIleAsnLysLeuGly-151 164-LysLeuAsnAspArgHisSerPheGly-172 180-ThrSerAlaGluLeuArgLysTyrAla-188 191-GlyIleLysSerLysAlaGluIleLeuThrAlaLysProProLysProAsnGlyValAlaGluAlaAlaLys IleGlnAlaAspGlyHisAlaAspValLysGlySerAspTrpGly-229 239-AspIleAsnAspArgAlaArgValGlyValAsnTyrArgSerLysValSerHisThrLeuLysGlyAspAla GluTrpAlaAla-266 285-ThrAlaAsnGluLysAlaArgValLysIleValThrProGluSer-299 306-TyrLysValSerAspLysAlaAspLeu-314 319-ThrTrpThrArgHisSerArgPheAspLysAlaGluLeuValPheGluLysGluLysThrValValLysGly LysSerAspArgThrThrIle-349 351-ProAsnTrpArgAsnThrTyrLys-358 363-GlySerTyrGlnIleSerGlu-369 377-IleAlaPheAspLysSerProValArgAsnAlaAspTyrArgMetAsnSerLeuProAspGlyAsn-398 409-HisIleGlyLysAsnHisVal-415 426-AsnAspThrSerTyrArgThrAlaLysAlaSerGlyAsnAspValAspSerLysGlyAlaSerSerAlaArg PheLysAsnHisAla-454 Hydrophilic Regions - Hopp-Woods 61-ThrLysLeuAspSerSerGln-67 81-TyrGluAlaAspSerAlaThr-87 95-GlnGlySerLysSerGlyLysIleThrLys-104 135-ThrGluTyrGluLysAspSerValLeu-143 164-LysLeuAsnAspArgHisSer-170 180-ThrSerAlaGluLeuArgLysTyrAla-188 191-GlyIleLysSerLysAlaGluIleLeuThr-200 202-LysProProLysProAsnGlyValAlaGluAlaAlaLysIleGlnAla-217 219-GlyHisAlaAspValLysGlySerAsp-227 240-IleAsnAspArgAlaArgVal-246 250-TyrArgSerLysVal-254 258-LeuLysGlyAspAlaGluTrpAlaAla-266 285-ThrAlaAsnGluLysAlaArgValLysIleValThr-296 307-LysValSerAspLysAlaAspLeu-314 324-SerArgPheAspLysAlaGluLeuValPheGluLysGluLysThrValValLysGlyLysSerAspArgThr ThrIle-349 377-IleAlaPheAspLysSerProValArgAsnAlaAspTyrArgMet-391 393-SerLeuProAspGlyAsn-398 428-ThrSerTyrArgThrAlaLysAlaSerGlyAsnAspValAspSerLysGlyAlaSerSerAlaArgPheLys AsnHisAla-454 990 AMPHI Regions - AMPHI 89-LysSerGlnLeuGlnAspLeuTyrLys-97 128-ThrMetProAspLeuIleAsnLysLeuVal-137 151-ThrSerLeuAsnAsnIlePhe-157 191-ArgArgHisSerAspIleHisThrLeuGluThrSerAsp-203 260-ProGluAsnLeuLysThrLeuAspGly-268 293-TyrGluLeuLeuLeuLysGlnCys-300 372-AlaAspGlyTrpArgLysGlyVal-379 423-GlyTyrGlyGlyGlyValTyrAlaAlaTrp-432 442-AlaTyrLeuAspGlyTrpLeuGlnTyr-450 472-ThrAlaSerValGluGlyGlyTyrAsnAlaLeu-482 550-GlnProPheAlaAlaPheAsnValLeuHisArg-560 Antigenic Index - Jameson-Wolf 6-LeuGlySerAsnThrArgSerThrLysIleGlyAspAspAlaAspPheSerPheSerAspLysProLysProGl yThr-31 35-PheSerSerGlyLysThrAspGlnAsnSerSerGluTyrGlyTyrAspGluIleAsnIleGlnGlyLysAsnT yrAsnSerGlyIle-63 75-TyrIleThrGluLysTyrGlyAlaAspLeuLysGlnAlaVal-88 90-SerGlnLeuGlnAspLeuTyrLysThrArgProGluAlaTrpAlaGluAsnLysLysArgThrGluGluAlaT yr-114 120-ThrLysPheSerThrLeuLysGlnThrMetPro-130 145-HisSerAsnThrSerGlnThrSer-152 157-PheAsnLysLysLeuHisValLysIleGluAsnLysSerHisVal-171 179-ThrLysMetThrLeuLysAspSerLeuTrpGluProArgArgHisSerAspIleHisThrLeuGluThrSer AspAsnAlaArglleArgLeuAsnThrLysAspGluLysLeuThrValHisLysAspTyrAlaGlyGlyAlaAsp- 227 232-TyrAspValArgGluSerAspGluProAlaLeuThrPheGluAspLysValSerGlyGlnSerGlyValVal LeuGluArgArgProGluAsnLeuLysThrLeuAspGlyArgLysLeuIleAla-273 275-LysThrAlaAspSerGlySerPheAlaPheLysGlnAsnTyrArgGlnGlyLeu-292 298-LysGlnCysGluGlyGlyPhe-304 312-AlaIleProGluAlaGlu-317 335-ArgAlaAlaAspArgGlyAspAspValTyrAlaAlaAspProSerArgGlnLysLeu-353 358-IleGlyGlyArgSerHisGlnAsnIleArgGlyGlyAlaAlaAlaAspGlyTrpArgLysGlyVal-379 385-ValPheValArgGlnAsnGluGlySerArgLeuAla-396 400-MetGlyGlyArgAlaGlyGln-406 408-AlaSerValAsnGlyLysGlyGlyAlaAlaGlySerAspLeu-421 435-LeuArgAspLysGlnThrGlyAlaTyr-443 452-ArgPheLysHisArgIleAsnAspGluAsnArgAlaGluArgTyrLysThrLysGlyTrpThr-472 475-ValGluGlyGlyTyr-479 487-IleValGlyLysGlyAsnAsnValArg-495 510-AsnGlyGlyPheThrAspSerGluGlyThrAla-520 525-GlySerGlyGlnTrpGlnSerArgAlaGlyIleArgAlaLysThrArgPheAlaLeuArgAsnGlyValAsn -548 559-HisArgSerLysSerPheGlyValGluMetAspGlyGluLysGlnThrLeuAla-576 579-ThrAlaLeuGluGlyArgPheGlyIle-587 589-AlaGlyTrpLysGlyHisMet-595 600-GlyTyrGlyLysArgThrAspGlyAspLysGluAlaAlaLeu-613 Hydrophilic Regions - Hopp-Woods 8-SerAsnThrArgSerThrLysIleGlyAspAspAlaAspPheSerPheSerAspLysProLysProGlyThr-3 1 38-GlyLysThrAspGlnAsnSerSer-45 79-LysTyrGlyAlaAspLeuLysGlnAlaVal-88 96-TyrLysThrArgProGluAlaTrpAlaGluAsnLysLysArgThrGluGluAlaTyr-114 161-LeuHisValLysIleGluAsnLysSerHisVal-171 179-ThrLysMetThrLeuLys-184 186-SerLeuTrpGluProArgArgHisSerAsp-195 200-GluThrSerAspAsnAlaArgIleArgLeuAsnThrLysAspGluLysLeuThrVal-218 220-LysAspTyrAlaGly-224 233-AspValArgGluSerAspGluProAlaLeuThrPheGluAspLysValSerGly-250 255-ValLeuGluArgArgProGluAsnLeuLysThrLeuAspGlyArgLysLeuIleAla-273 275-LysThrAlaAspSerGly-280 312-AlaIleProGluAlaGlu-317 335-ArgAlaAlaAspArgGlyAspAspValTyrAla-345 347-AspProSerArgGln-351 361-ArgSerHisGlnAsnIleArgGly-368 373-AspGlyTrpArgLys-377 385-ValPheValArgGlnAsnGluGlySerArg-394 410-ValAsnGlyLysGlyGlyAlaAlaGly-418 435-LeuArgAspLysGlnThr-440 452-ArgPheLysHisArgIleAsnAspGluAsnArgAlaGluArgTyrLysThr-468 513-PheThrAspSerGluGlyThr-519 533-AlaGlyIleArgAlaLysThrArgPheAlaLeu-543 559-HisArgSerLysSerPheGlyValGluMetAspGlyGluLysGlnThrLeuAla-576 579-ThrAlaLeuGluGly-583 600-GlyTyrGlyLysArgThrAspGlyAspLysGluAlaAlaLeu-613 992 AMPHI Regions - AMPHI 6-ArgHisLeuLysAsnMetGlnIleLysLysIleMetLysTrp-19 24-LeuSerLeuLeuGlyAlaLeuGlyTyr-32 45-AlaValLeuAspValLeuGlyAlaAla-53 72-HisArgTyrThrGlyThrValSerLysValTyr-82 158-GlnValGlnAspGly-162 179-AspPheAlaAspTyr-183 Antigenic Index - Jameson-Wolf l-Me PheArgArgHisArgHisLeuLys-9 34-GlyTyrGlySerGluAlaValArg-41 52-AlaAlaGlyAspAlaGlySerAspAlaProAlaArgArgArgAlaSerAlaLysSerGlyHisArgTyrThr- 75 79-SerLysValTyrAspGlyAspThr-86 90-IleAspGlyAspGlyAlaLysHisLysIle-99 105-AspAlaProGluMetLysGlnAlaTyrGlyThrArgSerArgAspAsnLeuArgAlaAlaAlaGluGlyArg LysValSer-131 134-ValPheAspThrAspArgTyrGlnArgGluValAla-145 148-SerValGlyLysThrAspLeuAsn-155 168-LysSerTyrAlaLysGluGlnGlnAspLysAlaAspPhe-180 187-GlnIleGlnAlaGluArgGluArgLysGlyLeuTrpLysAlaLysAsnProGlnAlaPro-206 208-AlaTyrArgArgAlaGlyArgSerGlyGlyGlyAsnLysAspTrpMetAsp-224 Hydrophilic Regions - Hopp-Woods 1-MetPheArgArgHisArgHisLeuLys-9 54-GlyAspAlaGlySerAspAlaProAlaArgArgArgAlaSerAlaLysSerGlyHisArg-73 90-IleAspGlyAspGlyAlaLysHisLysIle-99 105-AspAlaProGluMetLysGln-lll 113-TyrGlyThrArgSerArgAspAsnLeuArgAlaAlaAlaGluGlyArgLysValSer-131 134-ValPheAspThrAspArgTyrGlnArgGluValAla-145 148-SerValGlyLysThrAspLeu-154 169-SerTyrAlaLysGluGlnGlnAspLysAlaAspPhe-180 187-GlnIleGlnAlaGluArgGluArgLysGlyLeuTrpLysAlaLysAsnPro-203 211-ArgAlaGlyArgSerGlyGlyGlyAsnLysAspTrpMet-223 993 AMPHI Regions - AMPHI 6-GlySerPheGlnGlyProLeuAspLeuLeuLeu-16 35-ThrGluGlnTyrLeuHisTyrIleAlaGlnIle-45 105-GlyLeuAspAlaLeuProArgAla-112 136-1leThrAspLeuThrGlnAlaTrpLeuGly-145 152-HisThrArgSerHisGluValIle-159 169-MetThrAlalleLeuArgArgLeuAsnGlyHisGlylleCysArgPheHisAspLeuPheAsn-189 199-ValAsnPheIleAlaLeuLeu-205 211-GlyLeuValArgIleValGln-217 Antigenic Index - Jameson-Wolf 20-ArgLysGlnAsnIleAsp-25 70-LeuLeuLeuProArgThrGluThrValGluAspGluGluAlaAspProArgAlaGluLeuValArg-91 108-AlaLeuProArgAlaGlyArgAspPhe-116 148-SerArgAlaLysHisThrArgSerHisGluValIleLysGluThrIleSer-164 172-IleLeuArgArgLeuAsnGlyHisGlyIle-181 186-AspLeuPheAsnProLysGlnGlyAla-194 207-LeuAlaLysGluGlyLeu-212 216-ValGlnGluAspGlyPheGlyGluIleArgIle-226 228-LeuAsnHisGluGlyAlaHisSerAspGlyIleSerGlyThrArgGlyGlyArgAspValPhe-248 Hydrophilic Regions - Hopp-Woods 20-ArgLysGlnAsnIleAsp-25 70-LeuLeuLeuProArgThrGluThrValGluAspGluGluAlaAspProArgAlaGluLeuValArg-91 108-AlaLeuProArgAlaGlyArg-114 148-SerArgAlaLysHisThrArgSerHisGluValIleLysGluThrIleSer-164 207-LeuAlaLysGluGlyLeu-212 216-ValGlnGluAspGlyPheGly-222 232-GlyAlaHisSerAspGlyIleSerGlyThrArgGlyGlyArgAspValPhe-248 996 AMPHI Regions - AMPHI 21-LysSerAlaArgThrHisAlaLysIlePro-30 50-ProGlyGluSerTyrProAlaGlnLeuGlnLysLeuThrGlyTrpAsn-65 75-ThrSerAlaGlnAlaLeuSerArgLeuProAla-85 104-LeuArgLysValProLysGlu-llO 115-AsnIleAlaLysIleIleGluThrValGlnLys-125 140-LeuGlyAlaLeuPheGlyHisLeuSerAsp-149 167-GlyAlaTrpAlaGlu-171 186-AsnGlyLysGlyTyrArgLysPheAlaGluAspLeuAsnGlnPheLeuArgLysGlnGlyPhe-206 Antigenic Index - Jameson-Wolf l-MetAsnArgArgThrPhe-6 18-CysGlyArgLysSerAlaArgThrHisAlaLysIleProGluGlySerThr-34 46-TyrGlyAlaAsnProGlyGluSerTyrPro-55 69-GlyGlyValSerGlyAspThrSerAla-77 87-LeuAlaArgLysProLys-92 99-GlyGlyAsnAspPheLeuArgLysValProLysGluGlnThrArgAlaAsnIle-116 121-GluThrValGlnLysGluAsnIlePro-129 l48-SerAspHisProLeuTyrGluAspLeuSerGluGluTyrGly-161 173-LeuGlyAspAsnAsnLeuLysSerAspGlnIleHisAlaAsnGlyLysGlyTyrArgLysPheAlaGluAsp LeuAsnGlnPheLeuArgLysGlnGlyPheArg-207 Hydrophilic Regions - Hopp-Woods 18-CysGlyArgLysSerAlaArgThrHisAlaLysIleProGlu-31 49-AsnProGlyGluSerTyr-54 71-ValSerGlyAspThrSerAla-77 87-LeuAlaArgLysProLys-92 102-AspPheLeuArgLysValProLysGluGlnThrArgAlaAsnIle-116 121-GluThrValGlnLysGluAsnIle-128 154-GluAspLeuSerGluGluTyrGly-161 176-AsnAsnLeuLysSerAspGlnIleHisAlaAsn-186 188-LysGlyTyrArgLysPheAlaGluAspLeuAsnGlnPheLeuArg-202 997 AMPHI Regions - AMPHI 18-TrpAlaGlyLeuSerAlaAlaVal-25 70-TyrArgGlyValLeuArgLeuMetLysThrIleGly-81 107-ProLeuProAlaProLeuHisIle-114 132-LeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGly-146 164-AlaAlaValMetGlnPheTrpGlnProLeuValTrpGly-176 189-ValLeuCysAsnValLeuSerAsp-196 222-AlaLeuAlaAspLeuGlnArg-228 241-ArgLeuAsnThrLeuPro-246 275-GluGlyThrProGluHisValGlnThrAla-284 300-TyrAlaGluProValArgLeuProAlaProLeuThrGlyLeuAlaAspGly-316 355-LysAlaHisAlaAspLeuLysArgIleLeuProHisLeu-367 369-GluProGluAlaVal-373 Antigenic Index - Jameson-Wolf 3-AsnThrProHisProArgProLysIle-ll 37-GluAlaGlyArgGlnAlaGlyGlyArgAlaArgThrLeuAlaGlyAsnThrAspGlyPheGly-57 78-LysThrIleGlySerAspProArgAlaAla-87 122-ArgArgAlaProThr-126 132-LeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGlyGlnProAspThrThr-151 156-LeuLysGlnArgAsnValProArg-163 180-ThrProLeuGluThrAlaSer-186 197-GlyValLeuThrLysLysSerGlySerAspTyrLeuLeuProLysGlnAspLeu-214 225-AspLeuGlnArgLeuGlyAlaAspIleArgLeuGluThrArgValCysArg-241 243 -AsnThrLeuProAspGlyLysVal-250 273-LeuProGluGlyThrProGluHisVal-281 312-GlyLeuAlaAspGlyThr-317 323 -CysArgGlyArgLeuGlyLeuProGluAsnGluVal-334 340-ValSerAspArgValGlyAla-346 351-AlaTrpAlaAspLysAlaHisAlaAspLeuLysArgIleLeu-364 367-LeuGlyGluProGluAlaValArgValIleThrGluLysArgAlaThrThrAlaAlaAspAlaProProPro AspLeu-392 402-ProAlaGlyAspTyrLeuHisProAspTyrProAla-413 Hydrophilic Regions - Hopp-Woods 5-ProHisProArgProLysIle-ll 37-GluAlaGlyArgGlnAlaGlyGlyArgAlaArgThrLeuAlaGlyAsn-52 80-IleGlySerAspProArgAlaAla-87 122-ArgArgAlaProThr-126 132-LeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGlyGlnProAspThrThr-151 198-ValLeuThrLysLysSerGlySer-205 208-LeuLeuProLysGlnAspLeu-214 225-AspLeuGlnArgLeuGlyAlaAspIleArgLeuGluThrArgValCysArg-241 246-ProAspGlyLysVal-250 276-GlyThrProGluHisVal-281 325-GlyArgLeuGlyLeuProGluAsnGluVal-334 340-ValSerAspArgValGly-345 35l-AlaTrpAlaAspLysAlaHisAlaAspLeuLysArgIleLeu-364 368-GlyGluProGluAlaValArgValIleThrGluLysArgAlaThrThrAlaAlaAspAlaProProPro-39 0 999 AMPHI Regions - AMPHI 6-LeuIleSerAlaIleCysValSerIle-14 30-GluProValGlnSerIleGlnAlaAla-38 117-GlyGlnAsnLeuValAsnAsnAlaIleAsnGlyLeuHisSerIleGlnAlaValLeuSer-136 138-ThrThrThrAspLys-142 151-GlnLeuPheThrAlaLeuThrGluValValLysGluSer-163 Antigenic Index - Jameson-Wolf l-MetAsnMetLysLysLeuIle-7 18-AlaCysAsnGlnGlnSerLysThrAlaGlnAlaGluGluProValGln-33 42-AlaProMetAspIleThrVal-48 57-GlnAlaPheLysThrGlnAsnValSer-65 67-LysIleHisAsnLysAsnIleValLysThrAspCysGlyTyr-80 94-LysLeuAspGluGlnGlnLysIleArgAla-103 lll-LysThrAspGlyGluLysGlyGlnAsnLeu-120 138-ThrThrThrAspLysLeuGlyGluSerGluAlaGlyLys-150 158-GluValValLysGluSerAsnGlnThrGly-167 169-ThrAlaGlnLysAspValProAlaAspGly-178 185-PheGluLysGluThrAsnThr-191 195-IleGlyArgLysGlnPro-200 Hydrophilic Regions - Hopp-Woods l-MetAsnMetLysLysLeuIle-7 21-GlnGlnSerLysThrAlaGlnAlaGluGluProValGln-33 72-AsnIleValLysThrAspCysGlyTyr-80 94-LysLeuAspGluGlnGlnLysIleArgAla-103 112-ThrAspGlyGluLysGlyGlnAsn-119 139-ThrThrAspLysLeuGlyGluSerGluAlaGlyLys-150 158-GluValValLysGluSerAsnGln-165 169-ThrAlaGlnLysAspValProAla-176 185-PheGluLysGluThrAsn-190 195-IleGlyArgLysGlnPro-200 aOOl AMPHI Regions - AMPHI 7-AlaAlaArgArgMet-ll 69-PhePheGlySerAlaCysAsnSerAlaAla-78 Antigenic Index - Jameson-Wolf 3-ProGlnGlyLysAlaAlaArgArgMetSerAlaAsnGluValCys-17 31-ThrLeuProLysArgAspThrLeuAsnGlySerGlyThr-43 53-ProArgSerLeuArgSerLysSerThr-61 68-ArgPhePheGlySerAlaCysAsnSerAlaAlaArgArgSerSerCysProSerProLysIleGly-89 100-ValProSerGluProIleLeuArgLysSerSerGlyGluLysHisSerVal-116 118-AlaAspCysProCysAlaSerGlyArgTrpAspLysThrAla-131 Hydrophilic Regions - Hopp-Woods 5-GlyLysAlaAlaArgArgMetSerAla-13 32-LeuProLysArgAspThrLeuAsn-39 54-ArgSerLeuArgSerLysSer-60 76-SerAlaAlaArgArgSerSerCysProSerProLys-87 104-ProIleLeuArgLysSerSerGlyGluLysHisSerVal-116 125-GlyArgTrpAspLysThrAla-131 a003 AMPHI Regions - AMPHI 72-AsnGlnValValLeu-76 82-IleValGluValPheGlnArg-88 138-ArgIleAsnAspAlaGluGluIleLeuGlnAspValValAlaGluPheValGlyIleValGlyHisPheAsp GlyPheGlyVal-165 174-PheIleAlaArgIlePheArgVal-181 Antigenic Index - Jameson-Wolf 91-PheAsnAsnGluGlyGln-96 104-PheGluGlyGlyGlyAspAspGlyPhe-112 137-GlyArgIleAsnAspAlaGluGluIleLeu-146 204-ProGluAlaAlaAlaGlyGluValAspGlyAlaArgValHisAsp-218 Hydrophilic Regions - Hopp-Woods 106-GlyGlyGlyAspAspGlyPhe-112 137-GlyArgIleAsnAspAlaGluGluIleLeu-146 205-GluAlaAlaAlaGlyGluValAspGlyAlaArgValHisAsp-218 a005 AMPHI Regions - AMPHI 14-IleGlnSerMetTrpLysGlu-20 30-LeuGluLeuLeuThrValPheGlyAlaIleAla-40 60-LeuThrAspPheSerGluAsnTyr-67 105-ArgLeuLysGluGlyGlyGluLysSerSerGlu-115 175-GlnLeuArgArgLeuArg-180 214-AlaIleValGlySerValGlyValValAlaGluValProAsnIleHisArgLeuLeuLysLys-234 247-PheLysArgThrVa1-251 272-ThrHisGlnLeuPheLysGln-278 306-LeuAsnLeuIleAspGluIleSerThr-314 318-LeuLeuLeuLysAlaPhe-323 Antigenic Index - Jameson-Wolf 8-MetProGluGlnGluGluIleGlnSerMetTrp-18 48-GlnSerLysLysGlnSerGluSerGlySer-57 62-AspPheSerGluAsnTyrLysLysGlnArgGlnSerPhe-74 80-SerGlyGluGluAlaLysHisGlnGluLysGluGluLysLysLysGluLysAlaGluAlaLysAlaGluLysL ysArgLeuLysGluGlyGlyGluLysSerSerGluThrGlnLysSerArg-120 136-GluSerLeuArgHisGluIle-142 149-AlaLysProGluAspGluValLeuLeu-157 159-LeuGluSerProGlyGlyVal-165 175-GlnLeuArgArgLeuArgGluArgAsnIle-184 189-AlaValAspLysValAlaAla-195 230-ArgLeuLeuLysLysHisAspIleAspVal-239 245-GlyGluPheLysArgThr-250 256-GluAsnThrGluLysGlyLysGlnLysPheArgGlnGluLeuGluGluThrHisGln-274 279-PheValSerGluAsnArgProGlnLeuAspIleGluGluValAlaThr-294 310-AspGluIleSerThrSerAspAspLeuLeu-319 323-PheGluAsnLysGlnValIle-329 332-LysTyrGlnGluLysGlnSerLeu-339 349-AlaSerValGluLysLeuPhe-355 359-ValAsnArgArgAlaAspVal-365 Hydrophilic Regions - Hopp-Woods 8-MetProGluGlnGluGluIleGlnSerMetTrp-18 48-GlnSerLysLysGlnSerGluSerGly-56 62-AspPheSerGluAsnTyrLysLysGlnArgGlnSerPhe-74 81-GlyGluGluAlaLysHisGlnGluLysGluGluLysLysLysGluLysAlaGluAlaLysAlaGluLysLysA rgLeuLysGluGlyGlyGluLysSerSerGluThrGlnLysSerArg-120 136-GluSerLeuArgHisGluIle-142 149-AlaLysProGluAspGluValLeuLeu-157 159-LeuGluSerProGly-163 175-GlnLeuArgArgLeuArgGluArgAsnIle-184 189-AlaValAspLysValAlaAla-195 230-ArgLeuLeuLysLysHisAspIleAspVal-239 245-GlyGluPheLysArg-249 256-GluAsnThrGluLysGlyLysGlnLysPheArgGlnGluLeuGluGluThrHisGln-274 279-PheValSerGluAsnArgProGlnLeuAspIleGluGluValAlaThr-294 310-AspGluIleSerThrSerAspAspLeuLeu-319 323-PheGluAsnLysGlnValIle-329 332-LysTyrGlnGluLysGlnSerLeu-339 349-AlaSerValGluLysLeuPhe-355 359-ValAsnArgArgAlaAspVal-365 a006-l AMPHI Regions - AMPHI 40-GlnAlaTrpGlnAlaLeuLeuTyrAlaLeuValValLeu-52 61-ArgArgIleAlaAspThrArgThrPheThrArgIleTyrThrGlu-75 103-GluPheValSerPhePheGlu-109 117-ThrSerValValSerIlePheGlyAlaCysIleMetLeuLeu-130 179-GlyAspGluArgGlnLeu-184 186-ArgHisTyrGlyLeuLeuAlaArgLeu-194 228-GlyTyrSerSerAlaGlyHisValTyrSer-237 249-LeuAspAspValProArgLeuValGluGlnTyrSerAsnLeuLysAspIle-265 Antigenic Index - Jameson-Wolf 1-SerGlnAsnHisArgLysArgLeu-8 59-AlaAlaArgArgIleAlaAspThrArgThrPheThr-70 82-LeuGluGlnArgGlnArgGlnValProHisSer-92 163-PheArgLeuLySAsnSerLeuGluArgAspAsnHisPhel1eArgLysGlyAspGluArgGlnLeuAspArg HisTyr-188 198-IleSerAsnArgGluAlaPhe-204 227-LysGlyTyrSerSer-231 249-LeuAspAspValProArgLeuValGluGlnTyrSerAsnLeuLysAspIleGlyGln-267 269-IleGluTrpSerLysArgAsnIleLysAlaGlyThr-280 Hydrophilic Regions - Hopp-Woods 1-SerGlnAsnHisArgLysArgLeu-8 59-AlaAlaArgArgIleAlaAspThrArgThrPhe-69 82-LeuGluGlnArgGlnArgGlnValPro-90 166-LysAsnSerLeuGluArgAspAsnHisPheIleArgLysGlyAspGluArgGlnLeuAspArg-186 198-IleSerAsnArgGluAla-203 249-LeuAspAspValProArgLeuValGlu-257 260-SerAsnLeuLysAspIleGlyGln-267 269-IleGluTrpSerLysArgAsnIleLysAlaGlyThr-280 a007-l AMPHI Regions - AMPHI 71-HisSerMetValLysGlyIleAsn-78 105-ValAlaThrTyrIleMetAsnAlaPheAspAsnGlyGlyGly-118 Antigenic Index - Jameson-Wolf l-MetAsnThrThrArgLeu-6 20-SerAlaAlaAspAsnSerIleMetThrLysGlyGlnLysValTyrGluSerAsnCys-38 41-CysHisGlyLysLysGlyGluGlyArgGlyThr-51 55-ProLeuTyrArgSerAspPheIleMetLysLysProGln-67 83-ValAsnGlyLysThrTyrAsnGly-90 98-SerAspAlaAspIle-102 112-AlaPheAspAsnGlyGlyGlySerValThrGluLysAspValLysGlnAlaLysAsnLysLys-132 Hydrophilic Regions - Hopp-Woods 26-IleMetThrLysGlyGlnLysValTyrGlu-35 42-HisGlyLysLysGlyGluGlyArgGly-50 61-PheIleMetLysLysProGln-67 98-SerAspAlaAspIle-102 119-SerValThrGluLysAspValLysGlnAlaLysAsnLysLys-132 a008 AMPHI Regions - AMPHI 15-LeuGluAsnProAlaGlnGlnValArgAlaAlaLeuAspThrLeuSer-30 54-GlnProAspPheValAsnAlaVal-61 69-AspGlyIleAlaLeuLeuAlaGluLeuAsnArg-79 90-PheArgAsnAlaPro-94 129-ArgProLeuAlaGluIleLeuProAsp-137 144-GlyLysValAlaGluLeuSerLysArgLeuGly-154 Antigenic Index - Jameson-Wolf l-MetAsnAsnArgHis-5 12-GlySerAsnLeuGluAsnProAlaGlnGlnVal-22 29-LeuSerSerHisProAspIleArgLeuLysGlnAlaSerSer-42 49-ValGlyTyrAspAsnGlnProAspPhe-57 76-GluLeuAsnArgIleGluAlaAspPheGlyArgGluArgSerPheArgAsnAlaProArgThrLeuAspLeuA spIlelleAspPheAspGlylleSerSerAspAspProArgLeuThrLeuProHisProArgAlaHisGluArgSe rPheVal-127 140-LeuGlyLysHisGlyLysValAlaGluLeuSerLysArgLeuGlyAsnGlnGlyIle-158 160-LeuLeuProAspLys-164 Hydrophilic Regions - Hopp-Woods 14-AsnLeuGluAsnProAlaGlnGlnVal-22 33-ProAspIleArgLeuLysGln-39 76-GluLeuAsnArgIleGluAlaAspPheGlyArgGluArgSerPheArgAsnAlaProArgThrLeuAsp-98 105-AspGlyIleSerSerAspAspProArgLeu-114 120-ArgAlaHisGluArgSerPheVal-127 142-LysHisGlyLysValAlaGluLeuSerLysArgLeuGly-154 160-LeuLeuProAspLys-164 a009 Antigenic Index - Jameson-Wolf 6-ValAlaPheGluArgHisHisHisLysSerLysAlaGluGlnAsnThrHisArgArgAlaAspAlaGluIleAl aGlu-31 37-AsnGlnHisThrGlnAlaArgLysGlnSer-46 57-PheSerAspLysVal-61 77-AlaAspGlyGlyLysThrTrpGlnLysPro-86 Hydrophilic Regions - Hopp-Woods 6-ValAlaPheGluArgHisHisHisLysSerLysAlaGluGlnAsnThrHisArgArgAlaAspAlaGluIleAl aGlu-31 40-ThrGlnAlaArgLysGlnSer-46 78-AspGlyGlyLysThrTrpGln-84 aOlO-1 AMPHI Regions - AMPHI 54-SerAlaSerLeuGly-58 70-TyrAspThrValLysGly-75 115-TyrGlnArgProPheGlyGlyHis-122 125-GluHisGlyLysArgAlaVal-131 146-LeuHisThrLeuTyrGln-151 210-AlaSerSerThrAsn-214 216-TyrMetAsnThrGlyAspGly-222 275-ArgTyrAlaProThrValLys-281 322-IleMetGluLysLeuProGlyIleArg-330 338-GlyIleAspProIleLysAspProIlePro-347 357-GlyGlyIleProThrAsnTyrHis-364 413-AlaAlaGlyAspSerMetIleLysPheIleLysGluGlnSerAspTrp-428 446-LeuAspAsnGlnThrAsp-451 453-GluAsnValAspAlaLeuArgArgGluLeu-462 479-LeuSerLysGlyValArgGluValMetAlaIleAlaGlu-491 505-TrpAsnThrAlaArg-509 514-GluLeuAspAsnLeuIleGluValAlaLys-523 Antigenic Index - Jameson-Wolf 14-GlyGlyGlyGlyAlaGlyLeu-20 26-LeuSerLysSerGlyLeu-31 40-PheProThrArgSerHisThr-46 59-AsnValGlnGluAspArgTrpAsp-66 71-AspThrValLysGlySerAspTrpLeuGlyAspGlnAspAlaIle-85 104-MetProPheAspArgValGluSerGlyLysIleTyrGlnArgProPheGly-120 123-ThrAlaGluHisGlyLysArgAlaValGluArgAlaCysAlaValAlaAspArgThrGly-142 152-GlnAsnValArgAlaAsnThrGln-159 168-AspLeuIleArgAspGluAsnGlyAspVal-177 183-MetGluMetGluThrGlyGlu-189 202-ThrGlyGlyGlyGlyArgIle-208 211-SerSerThrAsnAla-215 218-AsnThrGlyAspGlyLeu-223 231-IleProLeuGluAspMetGlu-237 255-GluGlyValArgGlyGluGlyGlyIle-263 266-AsnAlaAspGlyGluArgPheMetGlu-274 276-TyrAlaProThrValLysAspLeuAlaSerArgAspValValSer-290 297-IleTyrGluGlyArgGlyCysGlyLysAsnLysAspHisVal-310 315-AspHisIleGlyAlaGluLysIleMetGluLysLeuProGlyIleArgGluIleSer-333 338-GlyIleAspProIleLysAspProIle-346 368-ValValProGlnGlyAspGluTyrGluValProVal-379 395-GlyAlaAsnArgLeuGlyThrAsnSerLeu-404 413-AlaAlaGlyAspSerMet-418 421-PheIleLysGluGlnSerAspTrpLysProLeuProAlaAsnAlaGlyGluLeuThrArgGlnArgIleGlu ArgLeuAspAsnGlnThrAspGlyGluAsnValAspAlaLeuArgArgGluLeuGlnArgSer-465 473-PheArgThrAspGluIleLeuSerLysGlyValArgGlu-485 487-MetAlaIleAlaGluArgValLysArgThrGluIleLysAspLysSerLysVal-504 508-AlaArgIleGluAlaLeuGluLeu-515 529-AlaGluAlaArgLysGluSerArgGlyAlaHisAlaSerAspAspHisProGluArgAspAspGluAsnTrp Met-553 558-TyrHisSerAspAlaAsnThrLeuSerTyrLysProValHisThrLysProLeuSer-576 581-LysProAlaLysArgValTyr-587 Hydrophilic Regions - Hopp-Woods 26-LeuSerLysSerGlyLeu-31 59-AsnValGlnGluAspArgTrpAsp-66 71-AspThrValLysGly-75 77-AspTrpLeuGlyAspGlnAspAlaIle-85 105-ProPheAspArgValGluSerGlyLysIleTyr-115 123-ThrAlaGluHisGlyLysArgAlaValGluArgAlaCysAlaValAlaAspArgThrGly-142 168-AspLeuIleArgAspGluAsnGlyAsp-176 183-MetGluMetGluThrGlyGlu-189 231-IleProLeuGluAspMetGlu-237 255-GluGlyValArgGlyGluGly-261 267-AlaAspGlyGluArgPheMetGlu-274 276-TyrAlaProThrValLysAspLeuAlaSerArgAspValValSer-290 297-11eTyrGluGlyArgGlyCysGlyLysAsnLysAspHisVal-310 315-AspHisIleGlyAlaGluLysIleMetGluLysLeuProGlyIleArgGluIleSer-333 340-AspProIleLysAspProIle-346 371-GlnGlyAspGluTyrGluValProVal-379 421-PheIleLysGluGlnSerAspTrpLysPro-430 434-AsnAlaGlyGluLeuThrArgGlnArgIleGluArgLeuAspAsnGlnThrAspGlyGluAsnValAspAla LeuArgArgGluLeuGlnArg-464 473-PheArgThrAspGluIleLeuSerLysGlyValArgGlu-485 487-MetAlaIleAlaGluArgValLysArgThrGluIleLysAspLysSerLysVal-504 508-AlaArgIleGluAlaLeuGluLeu-515 529-AlaGluAlaArgLysGluSerArgGlyAlaHisAlaSerAspAspHisProGluArgAspAspGluAsnTrp Met-553 581-LysProAlaLysArgValTyr-587 aOll AMPHI Regions - AMPHI 58-IleArgLeuIleAsnAlaAla-64 83-AlaIleLeuThrLys-87 116-GluValLeuHisArgTyrLeuProGlnMetLeuSerAlaGly-129 147-MetAlaXxxMetGlyLysValMetGlyVal-156 Antigenic Index - Jameson-Wolf 1-Me ArgThrHisArgLysThrCysSer-9 17-ThrAlaSerLysProAlaValSerIleArgHisProSerGluAsnIleMet-33 37-IleArgLeuThrGluAspMetLysThrAlaMetArgAlaLysAspGlnVal-53 66-LysGlnPheGluValAspGluArgThrGluAlaAspAspAlaLysIle-81 88-MetValLysGlnArgLysAspSerValLysIle-98 100-ThrGluAlaGlyArgGlnAspLeuAlaAspLysGluAsnAlaGluIle-115 127-SerAlaGlyGluIleArgThrAlaVal-135 157-XxxLysThrArgLeuAlaGlyLysAlaAspMetGlyGluValAsnLysIleLeu-174 Hydrophilic Regions - Hopp-Woods 1-MetArgThrHisArgLysThrCys-8 37-IleArgLeuThrGluAspMetLysThrAlaMetArgAlaLysAspGlnVal-53 66-LysGlnPheGluValAspGluArgThrGluAlaAspAspAlaLysIle-81 88-MetValLysGlnArgLysAspSerValLysIle-98 100-ThrGluAlaGlyArgGlnAspLeuAlaAspLysGluAsnAlaGluIle-115 129-GlyGluIleArgThrAlaVal-135 157-XxxLysThrArgLeuAlaGlyLysAlaAspMetGlyGluValAsnLysIleLeu-174 a012-l AMPHI Regions - AMPHI 19-LysLeuLeuGluGlnLeuMetArgPheLeuGlnPheLeuSerGluPheLeuPheAlaLeuPheArgIle-41 48-ArgAlaLeuLysPheAlaArgArg-55 89-AsnAsnPheIleArgHisThr-95 160-GlnGlyPheTyrGlyVal-165 179-GlyPheLeuArgPheGlyArgPheLeuProThrLeuLeuGlnThrLeu-194 Antigenic Index - Jameson-Wolf 42-PheThrHisLysSerAsnArgAlaLeuLysPheAlaArgArgHisHis-57 72-ArgTyrPheArgTyrAsnThrHisArgThrAspAsnArgLysArgSerGlyAsnAsnPhe-91 93-ArgHisThrArgHisHis-98 101-ThrAlaArgArgHisLeuIleAspGlyAspGlyGlnArgAsn-114 119-GlnThrProLysLeuArgSerArgGln-127 137-ThrPheGlnSerLysGlnAsnLeu-144 147-ArgLeuGlyAsnGlnLysHisArgArgAsnLeuMetThrGln-160 173-IleGlnHisLysLysAlaGly-179 Hydrophilic Regions - Hopp-Woods 45-LysSerAsnArgAlaLeuLysPheAlaArgArgHisHis-57 77-AsnThrHisArgThrAspAsnArgLysArgSerGly-88 101-ThrAlaArgArgHisLeuIleAspGlyAspGlyGlnArg-113 121-ProLysLeuArgSerArgGln-127 149-GlyAsnGlnLysHisArgArgAsnLeu-157 173-IleGlnHisLysLysAlaGly-179 a015 AMPHI Regions - AMPHI 25-ValPheXxxLeuTrpLysAsnProGluLysProLeuAlaGlyPheTrpLysAlaLeuProHis-45 107-MetCysCysLeuThrCys-112 Antigenic Index - Jameson-Wolf 29-TrpLysAsnProGluLysProLeu-36 90-MetArgAlaArgProArgSerThrLys-98 Hydrophilic Regions - Hopp-Woods 30-LysAsnProGluLysProLeu-36 90-MetArgAlaArgProArgSerThrLys-98 a018-2 AMPHI Regions - AMPHI 6-IleGlnHisLeuArg-10 100-AspGlyAlaAlaAla-104 152-ArgIleGlyAsnGlyTyr-157 Antigenic Index - Jameson-Wolf l-MetValGluArgHisIleGln-7 9-LeuArgAsnGlyHis-13 19-ProSerGlnGlnValArg-24 27-PheGlyGlyArgThrTyrAspPheCysAlaAspGluAlaAla-40 67-TyrPheAlaAspAspLysPhe-73 78-LeuArgGlyAsnLeuArg-83 85-PheGlnThrAspLysAlaAspLeuArgThrGlyGluHisTyrAlaAspGlyAlaAla-103 108-AlaAspIleArgVal-112 136-ArgValAlaArgAsnLysAspMetArgAsnThrGlyLeuHisSerGlnArgIleGlyAsnGlyTyr-157 Hydrophilic Regions - Hopp-Woods l-MetValGluArgHisIleGln-7 35-CysAlaAspGluAlaAla-40 67-TyrPheAlaAspAspLysPhe-73 85-PheGlnThrAspLysAlaAspLeuArgThrGlyGluHisTyrAla-99 108-AlaAspIleArgVal-112 136-ArgValAlaArgAsnLysAspMetArgAsn-145 a019-2 AMPHI Regions - AMPHI 33 -ProAlaAspAsnIleGlu-38 55-GlyLysThrLeuAlaAspTyrGlyGlyTyrProSerAlaLeuAspAla-70 80-AlaAlaTyrLeuGluAsnAlaGlyAsp-88 90-AlaMetAlaGluAsnValArgAsnGluTrpLeuLysSer-102 142-AlaAlaGluLeuValLysAsnThrGlyLysLeuProSerGlyCysThrLysLeuLeuGluGlnAlaAlaAla Ser-166 173-AspAlaTrpArgArgValArg-179 193-LeuAlaAlaAlaLeuGlySerProPheAspGlyGlyThrGlnGly-207 215-AsnValIleGlyLysGluAlaArgLysSer-224 229-AlaLeuLeuSerGluMet-234 259-AsnValProAlaAlaLeuAspTyrTyrGly-268 292-ArgArgTrpAspGluLeuAlaSerValIleSerHisMetProGluLysLeuGlnLys-310 329-GlnGluAlaGluLysLeuTyrLysGlnAla-338 451-ArgTyrIleSerPro-455 495-GlnGlyLeuMetGlnValMet-501 582-ArgAspTyrValLysLysValMet-589 Antigenic Index - Jameson-Wolf 3-ProProSerLeuLys-7 22-SerSerThrAsnThrLeuSerAlaAspLysThrProAlaAspAsnIleGluThrAlaAspLeuSerAlaSerV alProThrArgProAlaGluProGluGlyLysThrLeuAlaAspTyrGlyGlyTyrProSerAla-67 69-AspAlaValLysGlnLysAsnAspAla-77 85-AsnAlaGlyAspSerAlaMet-91 103-LeuGlyAlaArgArgGln-108 115-GluTyrAlaLysLeuGluProAlaGlyArgAlaGlnGluValGluCysTyrAlaAspSerSerArgAsnAsp TyrThrArgAlaAlaGluLeuValLysAsnThrGlyLysLeuProSerGlyCys-156 167-GlyLeuLeuAspGlyAsnAspAlaTrpArgArgValArgGly-180 182-LeuAlaGlyArgGlnThrThrAspAlaArgAsn-192 199-SerProPheAspGlyGlyThrGlnGlySerArgGluTyr-211 217-IleGlyLysGluAlaArgLysSerProAsn-226 232-SerGluMetGluSerGlyLeuSerLeuGluGlnArgSer-244 254-GlnSerGlnAsnLeu-258 266-TyrTyrGlyLysValAlaAspArgArgGlnLeuThrAspAspGlnIle-281 287-AlaAlaLeuArgAlaArgArgTrpAspGlu-296 304-MetProGluLysLeuGlnLysSerProThr-313 320-ArgSerArgAlaAlaThrGlyAsnThrGlnGluAlaGluLysLeuTyrLys-336 339-AlaAlaThrGlyArgAsn-344 350-AlaGlyGluGluLeuGlyArgLysIleAspThrArgAsnAsnValProAspAlaGlyLysAsnSerVal-37 2 374-ArgMetAlaGluAspGlyAlaIleLys-382 389-ArgAsnSerArgThrAlaGlyAspAlaLysMetArgArgGlnAlaGlnAla-405 409-PheAlaThrArgGlyPheAspGluAspLysLeuLeu-420 438-SerAlaGluArgThrAspArgLysLeuAsnTyr-448 454-SerProPheLysAspThrValIle-461 464-AlaGlnAsnValAsnValAspProAla-472 478-IleArgGlnGluSerArgPhe-484 488-AlaGlnSerArgValGlyAla-494 504-ThrAlaArgGluIleAlaGly-510 520-TyrThrAlaAspGlyAsnIleArgMetGly-529 535-AspThrLysArgArgLeuGlnAsnAsnGluVal-545 550-GlyTyrAsnAlaGlyProGlyArgAlaArgArgTrpGlnAlaAspThrProLeuGlu-568 579-SerGluThrArgAspTyrValLys-586 606-LeuLysGlnArgMet-610 Hydrophilic Regions - Hopp-Woods 27-LeuSerAlaAspLysThrProAlaAspAsnIleGluThrAlaAspLeu-42 46-ValProThrArgProAlaGluProGluGlyLysThrLeuAla-59 69-AspAlaValLysGlnLysAsnAspAla-77 85-AsnAlaGlyAspSerAlaMet-91 103-LeuGlyAlaArgArgGln-108 115-GluTyrAlaLysLeuGluProAlaGlyArgAlaGlnGluValGluCysTyrAlaAspSerSerArgAsnAsp TyrThrArgAlaAlaGluLeuValLysAsnThrGlyLysLeuProSerGlyCys-156 170-AspGlyAsnAspAlaTrpArgArgValArgGly-180 185-ArgGlnThrThrAspAlaArgAsn-192 201-PheAspGlyGlyThrGlnGlySerArgGlu-210 217-IleGlyLysGluAlaArgLysSerProAsn-226 232-SerGluMetGluSer-236 238-LeuSerLeuGluGlnArgSer-244 270-ValAlaAspArgArgGlnLeuThrAspAspGlnIle-281 287-AlaAlaLeuArgAlaArgArgTrpAspGlu-296 304-MetProGluLysLeuGlnLys-310 320-ArgSerArgAlaAlaThr-325 327-AsnThrGlnGluAlaGluLysLeuTyrLys-336 350-AlaGlyGluGluLeuGlyArgLysIleAspThrArgAsnAsnValProAspAlaGlyLys-369 374-ArgMetAlaGluAspGlyAlaIleLys-382 389-ArgAsnSerArgThrAlaGlyAspAlaLysMetArgArgGlnAlaGlnAla-405 411-ThrArgGlyPheAspGluAspLysLeuLeu-420 438-SerAlaGluArgThrAspArgLysLeu-446 478-IleArgGlnGluSerArgPhe-484 488-AlaGlnSerArgValGly-493 504-ThrAlaArgGluIleAlaGly-510 535-AspThrLysArgArgLeuGlnAsn-542 554-GlyProGlyArgAlaArgArgTrpGlnAla-563 579-SerGluThrArgAspTyrValLys-586 606-LeuLysGlnArgMet-610 a023 AMPHI Regions - AMPHI 42-LysGluTyrSerAlaTrpGlnAlaPhePheSerGlnThrTrpValLysValPheThrGlnValSerPheIleA laValPheLeuHisAlaTrpValGly-74 82-TyrXxxLysProPhe-86 Antigenic Index - Jameson-Wolf l-MetValGluArgLysLeuThr-7 41-ProLysGluTyrSer-45 81-AspTyrXxxLysProPheGlyVal-88 Hydrophilic Regions - Hopp-Woods l-MetValGluArgLysLeuThr-7 a025 AMPHI Regions - AMPHI 15-AlaAlaGlnLeuGlyGlyCysProThrGlnHis-25 36-MetGlnThrValProSerAlaProValTyrAsnProTyrGlyAlaThrProTyr-53 lll-AspThrValTyrLysIleSerLysCysTyrHisIle-122 126-AspPheArgAlaTrpAsnGlyMetThrAsp-135 140-IleGlyGlnIleValLysVal-146 206-AspPheArgAlaTrpAsnGlyMetThrAsp-215 220-IleGlyGlnIleValLysVal-226 248-AlaValGlnThrProValLysProAlaAla-257 261-ValGlnSerAlaProGlnPro-267 290-SerGlyThrArgSer-294 307-LysValValAlaAspPhe-312 343-GlyLeuArgGlyTyrGlyAsn-349 Antigenic Index - Jameson-Wolf 22-ProThrGlnHisPro-26 33-AsnSerGlyMetGlnThr-38 58-AlaAlaAsnAspAlaPro-63 108-ValArgGlyAspThrValTyrLysIleSerLys-118 120-TyrHisIleSerGlnAspAspPheArgAla-129 131-AsnGlyMetThrAspAsnThrLeu-138 144-ValLysValLysProAlaGly-150 157-AlaAlaValLysSerArgProAla-164 188-ValArgGlyAspThr-192 195-AsnIleSerLysArgTyrHisIleSerGlnAspAspPheArgAla-209 211-AsnGlyMetThrAspAsnThrLeu-218 224-ValLysValLysProAlaGly-230 237-AlaAlaValLysSerArgProAla-244 252-ProValLysProAlaAlaGlnProProValGlnSerAlaProGlnPro-267 270-ProAlaAlaGluAsnLysAlaVal-277 280-ProAlaProGlnSerProAlaAlaSerProSerGlyThrArgSerValGly-296 302-ArgProThrGlnGlyLysValValAlaAspPheGlyGlyAsnAsnLysGlyValAsp-320 333-AlaAspGlyLysVal-337 342-SerGlyLeuArgGlyTyrGly-348 363-TyrGlyHisAsnGln-367 370-LeuValGlyGluGlyGlnGlnValLysArgGlyGlnGln-382 387-GlyAsnThrGluAlaSerArgThrGlnLeu-396 398-PheGluValArgGlnAsnGlyLysProValAsnProAsnSer-411 Hydrophilic Regions - Hopp-Woods 108-ValArgGlyAspThr-112 123-SerGlnAspAspPheArg-128 144-ValLysValLysPro-148 157-AlaAlaValLysSerArgProAla-164 188-ValArgGlyAspThr-192 200-TyrHisIleSerGlnAspAspPheArg-208 224-ValLysValLysPro-228 237-AlaAlaValLysSerArgProAla-244 253-ValLysProAlaAla-257 270-ProAlaAlaGluAsnLysAlaVal-277 290-SerGlyThrArgSer-294 313-GlyGlyAsnAsnLysGlyValAsp-320 333-AlaAspGlyLysVal-337 373-GluGlyGlnGlnValLysArgGlyGln-381 389-ThrGluAlaSerArgThr-394 400-ValArgGlnAsnGlyLysProValAsn-408 a032 AMPHI Regions - AMPHI 11-LeuArgArgProLeuArgGln-17 67-SerPheAlaGlyAsnValTyrProArgLeu-76 114-ValHisGlyGlnIleGlnHisProValGlnProPheLeuArg-127 134-LeuGlyLeuLeuArgArgPheAspVal-142 Antigenic Index - Jameson-Wolf l-MetArgArgAsnVal-5 10-ValLeuArgArgProLeuArg-16 28-ArgAlaValProAlaGlyLysGlnGlyPhe-37 41-CysArgLeuThrGlnArgGln-47 57-AlaGlyGlnArgAsnLeuPro-63 104-ValIleAlaHisArgGlnArgVal-lll 138-ArgArgPheAspValGlyGlyArgValGlyMet-148 151-ThrAlaPheAspGlnProGlyAla-158 160-LeuProProArgArgGlnLeuAlaArgGlnArgProArgIleGlnThrAlaLeuArgGlnProProGlnArg ArgArgLysIleAlaLeu-189 203-HisLeuCysGlnGlnArgLysGln-210 236-ValLysMetArgArgLysProValGlnAsnHisAsnArgProThrGlnIleSerLysLysGln-256 Hydrophilic Regions - Hopp-Woods 1-Me ArgArgAsnVal-5 10-ValLeuArgArgProLeuArg-16 28-ArgAlaValProAlaGlyLys-34 41-CysArgLeuThrGln-45 104-ValIleAlaHisArgGlnArgVal-lll 138-ArgArgPheAspValGlyGly-144 161-ProProArgArgGlnLeuAlaArgGlnArgProArgIle-173 177-LeuArgGlnProProGlnArgArgArgLysIleAlaLeu-189 203-HisLeuCysGlnGlnArgLysGln-210 236-ValLysMetArgArgLysProValGlnAsnHisAsnArgProThrGlnIleSerLysLysGln-256 a033-2 AMPHI Regions - AMPHI 6-GlnTyrGlyGlyLeuAlaGlyPheProLysArgCysGluSerGlu-20 64-GlyGlnAlaPheGluAlaLeuAsnCys-72 95-ValGlyAlaLeuProLysTyrLeuAlaSerAsnValValArgAspMetHisGlyLeuLeuSerThrVal-117 120-GlnThrGlyLysValLeuAspLysIleProGlyAlaMetGlu-133 142-IleLysThrLeuAlaGlu-147 157-SerLeuPheGluAsnPhe-162 168-GlyProValAspGlyHisAsnValGluAsnLeuValAspValLeuGluAspLeuArgGlyArg-188 207-AlaGluAsnAspPro-211 213-LysTyrHisAlaValAlaAsnLeuProLysGluSerAlaAla-226 242-TyrThrGlnValPheGlyLys-248 280-PheProAspArgTyrPheAspVal-287 307-LysProValValAlaIleTyrSer-314 316-PheLeuGlnArgAlaTyrAspGlnLeu-324 357-AspLeuSerPheLeuArgCysIleProAsnMetIleVal-369 390-AlaProAlaAlaValArgTyrProArg-398 407-SerAspGlyMetGluThrValGlu-414 419-IleIleArgArgGlu-423 432-PheGlySerMetValAla-437 453-MetArgPheValLysProIleAspGluGlu-462 469-ArgSerHisAspArgIle-474 489-AlaValLeuGluValLeu-494 510-AspThrValThrGlyHisGly-516 518-ProLysLysLeuLeu-522 Antigenic Index - Jameson-Wolf ll-AlaGlyPheProLysArgCysGluSerGluTyrAspAla-23 28-HisSerSerThrSerIle-33 41-AlaAlaAspLysGlnLeuGlyΞerAspArgArgSerVal-53 57-GlyAspGlyAlaMetThr-62 72-CysAlaGlyAspMetAspVal-78 85-AsnAspAsnGluMetSerIle-91 105-AsnValValArgAspMetHisGly-112 117-ValLysAlaGlnThrGlyLysValLeuAspLysIleProGly-130 134-PheAlaGlnLysValGluHisLysIleLysThrLeuAlaGluGluAlaGluHisAlaLysGln-154 166-TyrThrGlyProValAspGlyHisAsn-174 181-ValLeuGluAspLeuArgGlyArgLysGlyPro-191 197-IleThrLysLysGlyAsnGlyTyrLysLeuAlaGluAsnAspProValLys-213 220-LeuProLysGluSerAlaAla-226 228-MetProSerGluLysGluProLysProAlaAlaLysProThrTyr-242 253-ArgAlaAlaAlaAspSerArgLeu-260 266-AlaMetArgGluGlySerGlyLeuValGluPheGluGlnArgPheProAspArgTyrPhe-285 345-ValGlyAlaAspGlyProThrHis-352 370-AlaAlaProSerAspGluAsnGluCysArg-379 395-ArgTyrProArgGlyThrGlyThr-402 406-ValSerAspGlyMetGluThrValGluIleGlyLysGlyIleIleArgArgGluGlyGluLysThrAla-42 8 457-LysProIleAspGluGluLeuIle-464 467-LeuAlaArgSerHisAspArgIleValThrLeuGluGluAsnAlaGluGlnGlyGlyAlaGly-487 512-ValThrGlyHisGlyAspProLysLysLeuLeuAspAspLeuGlyLeu-527 530-GluAlaValGluArgArgValArg-537 540-LeuSerAspArgAspAlaAlaAsn-547 Hydrophilic Regions - Hopp-Woods 13-PheProLysArgCysGluSerGluTyrAsp-22 41-AlaAlaAspLysGlnLeuGlySerAspArgArgSerVal-53 74-GlyAspMetAspVal-78 85-AsnAspAsnGluMetSerIle-91 106-ValValArgAspMetHis-lll 123-LysValLeuAspLysIleProGly-130 134-PheAlaGlnLysValGluHisLysIleLysThrLeuAlaGluGluAlaGluHisAlaLysGln-154 181-ValLeuGluAspLeuArgGlyArgLysGlyPro-191 197-IleThrLysLysGlyAsnGly-203 205-LysLeuAlaGluAsnAspProValLys-213 220-LeuProLysGluSerAlaAla-226 228-MetProSerGluLysGluProLysProAlaAla-238 253-ArgAlaAlaAlaAspSerArgLeu-260 266-AlaMetArgGluGlySerGly-272 274-ValGluPheGluGlnArgPheProAspArgTyrPhe-285 372-ProSerAspGluAsnGluCys-378 408-AspGlyMetGluThrValGluIleGlyLysGlyIleIleArgArgGluGlyGluLysThrAla-428 457-LysProIleAspGluGluLeuIle-464 467-LeuAlaArgSerHisAspArgIleValThrLeuGluGluAsnAlaGluGlnGlyGly-485 513-ThrGlyHisGlyAspProLysLysLeuLeuAsp-523 530-GluAlaValGluArgArgValArg-537 540-LeuSerAspArgAspAlaAlaAsn-547 a034 AMPHI Regions - AMPHI 35-LeuAspHisAlaAla-39 52-AsnLeuGluGlnMetArgAlaIleMetGluAlaAlaAspGln-65 94-AlaValGluGluPheProHisIlePro-102 152-ThrValValAsnPheSer-157 168-IleGlyValLeuGlyAsnLeuGluThrGly-177 186-GlyAlaValGlyLysLeuSer-192 197-LeuThrSerValGluAspAlaValArgPheValLysAspThrGly-211 226-TyrLysPheThrArgProProThrGly-234 236-ValLeuArgIleAspArgIleLysGluIleHisGlnAlaLeu-249 261-SerValProGlnGluTrpLeuLysValIleAsnGluTyrGlyGlyAsnIleGlyGluThrTyrGlyValPro ValGluGluIleValGluGlyIleLysHisGly-295 314-ArgArgTyrLeuAlaGluAsn-320 330-LeuSerLysThrIleGluAlaMetLys-338 360-ValSerLeuGluLysMetAlaAsnArgTyrAlaLysGlyGluLeuAsnGlnIleVal-378 Antigenic Index - Jameson-Wolf 20-LeuProLysGluThrGln-25 37-HisAlaAlaGluAsnSerTyrGly-44 54-GluGlnMetArgAlaIleMetGluAlaAlaAspGlnVal-66 75-SerAlaGlyAlaArgLysTyrAla-82 106-HisGlnAspHisGlyAlaSerProAspValCysGlnArgSerIle-120 129-MetAspGlySerLeuMetGluAspGlyLysThrProSerSerTyrGluTyr-145 164-ValGluGlyGluIle-168 173AsnLeuGluThrGlyGluAlaGlyGluGluAspGlyVal-185 191-LeuSerHisAspGln-195 199-SerValGluAspAlaValArgPheValLysAspThrGlyValAsp-213 221-ThrSerHisGlyAla-225 227-LysPheThrArgProProThrGlyAspValLeuArgIleAspArgIleLysGluIleHis-246 258-GlySerSerSerValPro-263 271-AsnGluTyrGlyGlyAsnIleGlyGlu-279 287-GluIleValGluGlyIleLysHisGlyValArgLysValAsnIleAspThrAspLeuArgLeuAlaSerThr GlyAlaVal-313 316-TyrLeuAlaGluAsnProSerAspPheAspProArgLysTyrLeuSerLysThrIleGluAlaMetLys-33 8 350-CysGluGlyGlnAlaGlyLysIleLysProValSerLeuGluLysMetAlaAsnArgTyrAlaLysGlyGlu Leu-374 Hydrophilic Regions - Hopp-Woods 54-GluGlnMetArgAlaIleMetGluAlaAlaAspGlnVal-66 76-AlaGlyAlaArgLysTyrAla-82 108-AspHisGlyAlaSerProAspValCysGln-117 132-SerLeuMe GluAspGlyLysThrProSer-141 164-ValGluGlyGluIle-168 175-GluThrGlyGluAlaGlyGluGluAspGlyVal-185 199-SerValGluAspAlaValArgPheValLysAspThrGlyVal-212 235-AspValLeuArgIleAspArgIleLysGluIleHis-246 287-GluIleValGluGlyIleLysHisGlyValArgLysValAsnIleAspThrAspLeuArgLeu-307 320-AsnProSerAspPheAspProArgLysTyrLeuSerLysThrIleGluAlaMetLys-338 352-GlyGlnAlaGlyLysIleLysProValSerLeuGluLysMetAlaAsnArgTyrAlaLysGlyGluLeu-37 4 a036 AMPHI Regions - AMPHI 6-AlaValTyrSerAlaCysAlaAla-13 29-GlyArgCysValAsnGlnTyr-35 59-SerSerGlyArgPheCysGlnThrIleLys-68 106-AlaAlaSerAlaAlaGlnSer-112 213-SerAlaCysArgThrMetHisLysThrLeuArgProTyrVal-226 250-ArgLeuLysGluTyr-254 Antigenic Index - Jameson-Wolf 16-ProAlaArgThrSerSerSerArgArgCysValSerSerGlyArgCysValAsnGlnTyrSerSerArgAlaA spAla-41 43-ProTrpArgArgHisSerGlyAla-50 55-CysSerSerAspSerSerGlyArgPhe-63 73-ProSerPheSerAlaArgLysThrCysSerAspGlyGluThrSerAlaAspSerAsnTrpArg-93 96-HisAlaAspGlyLeuGlnThrAlaSerSer-105 112-SerAlaXxxThrAlaArgArgMetPheThr-121 132-GlnSerArgArgPheCysCysGlyArgArgAlaAlaArgArgValProGlnArgArgArgGluAsnArgLeu GlnProProAspXxxGlySerArgArgArgSerAlaTyrArgValCysLeuArgArgAlaAspGlyPheProAlaA rgThrHisCysArgCysArgLeuLysArgArgIleLeu-193 199-LeuProProAspArgProAspAsnArgSerAsnGlyGlyGlySerAlaCysArgThrMetHisLysThrLeu ArgProTyrValArgProGlnArgGlnGlyCys-233 239-AlaAlaArgArgArgHisArgAlaArgValArgArgLeuLysGluTyrGlnThr-256 260-AsnLeuAlaProArgArgCysArgTyrAla-269 Hydrophilic Regions - Hopp-Woods 18-ArgThrSerSerSerArgArgCysValSerSer-28 35-TyrSerSerArgAlaAsp-40 45-ArgArgHisSerGly-49 55-CysSerSerAspSerSerGlyArg-62 75-PheSerAlaArgLysThrCysSerAspGlyGluThrSerAla-88 114-XxxThrAlaArgArgMetPhe-120 135-ArgPheCysCysGlyArgArgAlaAlaArgArgValProGlnArgArgArgGluAsnArgLeuGlnProPro AspXxxGlySerArgArgArgSerAlaTyr-168 171-CysLeuArgArgAlaAspGlyPhePro-179 182-ThrHisCysArgCysArgLeuLysArgArglleLeu-193 200-ProProAspArgProAspAsnArgSerAsnGlyGly-211 217-ThrMetHisLysThrLeuArgProTyrValArgProGlnArgGlnGly-232 239-AlaAlaArgArgArgHisArgAlaArgValArgArgLeuLysGluTyrGln-255 262-AlaProArgArgCysArgTyr-268 a038 AMPHI Regions - AMPHI 100-GluAlaLysAspHis-104 157-GluLysGlyThrGlyGluLeuSerAlaValGlnGluValGluLys-171 178-AlaProIleAlaSerLeuAsn-184 195-GluPheGlyGlnPheLeuGluProValArgAlaTyrArgArgGlnTyrGlyVal-212 Antigenic Index - Jameson-Wolf 2-ThrAspPheArgGlnAspPhe-8 22-GluPheThrThrLysAlaGlyArgArgSerPro-32 38-GlyLeuPheAsnAspGlyLeu-44 58-IleGluSerGlyIleArg-63 85-LeuAlaGluLysGlyVal-90 96-TyrAsnArgLysGluAlaLysAspHisGlyGluGlyGly-108 125-ValIleSerAlaGlyThrSerValArgGluSerIleLysLeuIleGluAlaGluGlyAlaThr-145 153-LeuAspArgMetGluLysGlyThrGlyGlu-162 167-GlnGluValGluLysGlnTyrGlyLeu-175 191-GlnAsnAsnProGluPheGlyGln-198 203-ValArgAlaTyrArgArgGlnTyrGlyValGlu-213 Hydrophilic Regions - Hopp-Woods 2-ThrAspPheArgGlnAspPhe-8 22-GluPheThrThrLysAlaGlyArgArgSer-31 85-LeuAlaGluLysGlyVal-90 96-TyrAsnArgLysGluAlaLysAspHisGlyGlu-106 130-ThrSerValArgGluSerIleLysLeuIleGluAlaGluGlyAlaThr-145 153-LeuAspArgMetGluLysGlyThrGlyGlu-162 167-GlnGluValGluLysGlnTyr-173 204-ArgAlaTyrArgArgGlnTyrGly-211 a040 AMPHI Regions - AMPHI 14-AlaAlaProTyrIle-18 28-AlaGlyIleAspAsp-32 38-AspThrLeuAsnLysPhe-43 78-ProHisTyrCysArgGlyLeuArgValThrAspGlu-89 92-LeuGluGlnAlaGlnGlnPheAlaGly-100 113-SerValSerGlyPheAlaArgAlaPro-121 134-ArgProIleGlyValIleAspGly-141 146-TyrAlaGlyValIleArg-151 207-LeuSerAspGlyIleSerArgProAsp-215 226-GluAlaGlnSerLeuAlaGluHisAla-234 244-SerAlaValAlaAlaLeuGluGly-251 277-IleGlyThrSerIle-281 289-IleArgGlnAlaHisSerGlyAspIleProHisIleAlaAlaLeuIleArgProLeuGlu-308 320-TyrLeuGluAsnHisIleSerGluPheSerIle-330 338-TyrGlyCysAlaAlaLeuLysThrPheAlaGluAlaAsp-350 371-ArgLeuLeuAlaHisIle-376 386-SerArgLeuPheAla-390 Antigenic Index - Jameson-Wolf ll-PheArgGluAlaAlaProTyrIleArgGlnMetArgGlyLysThrLeu-26 29-GlylleAspAspArgLeuLeuGluGlyAspThrLeuAsn-41 65-HisPheLeuAspArgHisAlaAlaAlaGlnGlyArgThrProHisTyrCysArgGlyLeuArgValThrAspG luThrSerLeuGluGlnAlaGln-96 101-ThrValArgSerArgPheGlu-107 119-ArgAlaProSerVal-123 140-AspGlyThrAspMetGluTyr-146 150-IleArgLysThrAspThrAlaAla-157 173-LeuGlyHisSerTyrSerGlyLysThrPhe-182 208-SerAspGlyIleSerArgProAspGlyThrLeu-218 224-AlaGlnGluAlaGlnSerLeuAlaGluHisAlaGlyGlyGluThrArgArgLeuIle-242 249-LeuGluGlyGlyVal-253 261-GlyAlaAlaAspGlySerLeuLeu-268 272-PheThrArgAsnGlyIleGlyThrSerIleAlaLysGluAlaPheVal-287 289-IleArgGlnAlaHisSerGlyAspIle-297 305-ArgProLeuGluGluGlnGly-311 313-LeuLeuHisArgSerArgGluTyrLeu-321 331-LeuGluHisAspGlyAsnLeuTyr-338 345-ThrPheAlaGluAlaAspCysGlyGlu-353 361-ProGlnAlaGlnAspGlyGlyTyrGlyGluArgLeu-372 377-IleAspLysAlaArgGly-382 393-ThrAsnThrGlyGlu-397 402-ArgGlyPheGlnThrAlaSerGluAspGluLeuProGluThrArgArgLysAspTyrArgSerAsnGlyArg AsnSerHisIleLeu-430 Hydrophilic Regions - Hopp-Woods ll-PheArgGluAlaAlaPro-16 19-ArgGlnMetArgGlyLysThr-25 29-Gly11eAspAspArgLeuLeuGluGlyAspThrLeuAsn-41 65-HisPheLeuAspArgHisAlaAlaAlaGlnGlyArgThr-77 84-LeuArgValThrAspGluThrSerLeuGluGln-94 102-ValArgSerArgPheGlu-107 140-AspGlyThrAspMetGluTyr-146 150-IleArgLysThrAspThrAlaAla-157 210-GlyIleSerArgProAspGly-216 224-AlaGlnGluAlaGlnSerLeuAlaGlu-232 234-AlaGlyGlyGluThrArgArgLeuIle-242 291-GlnAlaHisSerGlyAsp-296 305-ArgProLeuGluGluGlnGly-311 315-HisArgSerArgGluTyrLeu-321 345-ThrPheAlaGluAlaAspCysGlyGlu-353 362-GlnAlaGlnAspGlyGlyTyrGlyGlu-370 377-IleAspLysAlaArgGly-382 402-ArgGlyPheGlnThrAlaSerGluAspGluLeuProGluThrArgArgLysAspTyrArgSerAsnGlyArg Asn-426 a041-l AMPHI Regions - AMPHI 6-AspProTyrArgHisPheGluAsnLeuAspSerAlaGluThr-19 45-AspGlyIleLeuAla-49 78-LysGlyValTyrArgValCysThrAlaAla-87 102-ValAlaAspPheAspGluLeuLeu-109 117-GlyValSerHisLeuValGluGlnProAsn-126 218-MetValAsnAlaTrpArgTyrLeuAsp-226 232-IleAspLeuIleGluAlaSer-238 258-LeuAsnLeuProAsnAspCysAspValValGlyTyrLeu-270 317-GlnAlaLeuGluSerValGluThr-324 331-AlaSerLeuLeuGluAsnValGlnGlyArg-340 354-ThrGluLeuProArgLeuProSer-361 382-AspPheThrThrProLeu-387 405-GlnProGlnGlnPhe-409 451-GlyPheGlyIleProGluLeuProHisTyrLeuGlySerIleGlyLys-466 493-AlaAlaGlnGlyIleSerLysHisLysSerValAspAspLeuLeuAlaValValSer-511 519-SerSerProGluHis-523 541-ValArgGluProGlnSer-546 556-LeuThrAspMetIleArgTyr-562 571-TrpThrAspGluTyrGlyAsnProGlnLysTyrGlu-582 591-LeuSerProTyrHisAsnLeuSerAspGlyIleAspTyrProPro-605 620-AlaHisAlaLeuLys-624 645-GlyHisThrGlyAsnGlyThrGlnArgGluAla-655 Antigenic Index - Jameson-Wolf l-MetLysSerTyrProAspProTyrArgHisPheGluAsnLeuAspSerAlaGluThrGln-20 26-AlaAsnAlaGluThrArgAlaArgPheLeuAsnAsnAspLysAlaArgAlaLeuSerAspGly-46 51-LeuGlnAspThrArgGlnIleProPhe-59 61-GlnGluHisArgAlaArg-66 72-GlnAspAlaGluTyrProLysGlyVal-80 89-TyrArgSerGlyTyrProGluTrp-96 104-AspPheAspGluLeuLeuGlyAspAspValTyr-114 123-GluGlnProAsnArg-127 132-LeuSerLysSerGlyGlyAspThr-139 145-ValAspLeuGluAlaGlyGluLeuValGlu-154 161-AlaGlyLysAsnHisValSerTrpArgAspGluAsnSerVal-174 178-ProAlaTrpAspGluArgGlnLeuThrGluSerGlyTyrProArgGluValTrpLeuValGluArgGlyLys SerPheGluGluSerLeu-207 212-IleAlaGluAspGlyMet-217 223-ArgTyrLeuAspProGlnGlySerProIleAspLeuIleGluAlaSerAspGlyPheTyr-242 250-SerAlaGluGlyGluAlaLysProLeuAsnLeuProAsnAspCysAspVal-266 278-LeuArgLysAspTrpHisArgAlaAsnGlnSerTyrProSer-291 298-LysLeuAsnArgGlyGluLeuGly-305 312-AlaProAsnGluThrGlnAla-318 320-GluSerValGluThrThrLys-326 337-ValGlnGlyArgLeuLysAla-343 345-ArgPheThrAspGlyLysTrpGlnGluThrGluLeuProArgLeuProSerGly-362 365-GluMetThrAspGlnProTrpGlyGly-373 401-ValMetArgArgGlnProGlnGlnPheAspSerAspGlyIleAsn-415 422-ThrSerAlaAspGlyGluArgIle-429 435-GlyLysAsnAlaAlaProAspMet-442 479-AsnIleArgGlyGlyGlyGluPheGlyProArgTrpHis-491 496-GlyIleSerLysHisLysSerValAspAsp-505 512-AspLeuSerGluArgGlyIleSerSerProGluHis-523 528-GlyGlySerAsnGly-532 540-PheValArgGluProGlnSerIleGlyAla-549 568-GlySerSerTrpThrAspGluTyrGlyAsnProGlnLysTyrGluValCysLysArgArgLeuGlyGluLeu SerProTyr-594 596-AsnLeuSerAspGlylleAspTyrPro-604 610-ThrSerLeuSerAspAspArgValHis-618 627-AlaLysLeuArgGluThrSerProGlnSer-636 639-TyrSerProAspGlyGlyGlyHisThrGlyAsnGlyThrGlnArgGluAlaAlaAspGluLeu-659 Hydrophilic Regions - Hopp-Woods 3-SerTyrProAspProTyrArgHis-10 12-GluAsnLeuAspSerAlaGluThr-19 26-AlaAsnAlaGluThrArgAlaArgPheLeuAsnAsnAspLysAlaArgAlaLeuSer-44 52-GlnAspThrArgGln-56 61-GlnGluHisArgAlaArg-66 72-GlnAspAlaGluTyrPro-77 104-AspPheAspGluLeuLeuGly-110 134-LysSerGlyGlyAsp-138 145-ValAspLeuGluAlaGlyGluLeuValGlu-154 166-ValSerTrpArgAspGluAsnSer-173 180-TrpAspGluArgGlnLeuThr-186 198-GluArgGlyLysSerPheGluGluSerLeu-207 212-IleAlaGluAspGlyMet-217 233-AspLeuIleGluAlaSerAsp-239 251-AlaGluGlyGluAlaLysPro-257 278-LeuArgLysAspTrpHisArg-284 298-LysLeuAsnArgGlyGluLeuGly-305 32O-GluSerValGluThrThrLys-326 337-ValGlnGlyArgLeuLysAla-343 350-LysTrpGlnGluThrGluLeuProArg-358 401-ValMetArgArgGlnProGlnGlnPheAspSerAspGlyI1eAsn-415 424-AlaAspGlyGluArg-428 436-LysAsnAlaAlaProAsp-441 481-ArgGlyGlyGlyGluPheGly-487 496-GlyIleSerLysHisLysSerValAspAsp-505 512-AspLeuSerGluArgGlyIleSerSer-520 540-PheValArgGluProGlnSer-546 571-TrpThrAspGluTyrGlyAsn-577 579-GlnLysTyrGluValCysLysArgArgLeuGlyGlu-590 612-LeuSerAspAspArgValHis-618 627-AlaLysLeuArgGluThrSer-633 650-GlyThrGlnArgGluAlaAlaAspGluLeu-659 a042-l AMPHI Regions - AMPHI 17-AlaLeuSerAsnThrSerThr-23 33-AlaValArgSerMetMetLysIle-40 138-SerProLeuValArgIleLeuProLeuSer-147 151-SerMetValValAlaPhePheAlaAsn-159 Antigenic Index - Jameson-Wolf 14-ArgThrSerAlaLeuSerAsnThrSerThrAlaAlaGlyProSerCys-29 49-TyrSerLysGluThrGlyCysProCysProSerLeuArgLysAspSerSerThrGlyGlyArgProMetSerP roCys-74 77-LeuAlaAsnArgAspCysValProLysAlaAspThr-88 93-ThrAspSerThrSerProArgProLeu-101 122-AlaArgAlaSerLeuProLysIleArgAlaLysVal-133 160-CysSerTyrAlaSerAlaProGlyPro-168 Hydrophilic Regions - Hopp-Woods 49-TyrSerLysGluThrGlyCys-55 59-SerLeuArgLysAspSerSerThrGlyGlyArgProMet-71 78-AlaAsnArgAspCysValProLysAlaAspThr-88 94-AspSerThrSerProArg-99 125-SerLeuProLysIleArgAlaLysVal-133 a043-2 AMPHI Regions - AMPHI 24-ValGluProSerArg-28 36-HisGlyGlyLeuAspGlyAlaAlaGlyPheAspGluGlyGluArg-50 59-AlaSerGlyAspGlyPhe-64 83-AlaGlyAspPheGlyAspGlyGlnArg-91 Antigenic Index - Jameson-Wolf l-MetProProAlaPro-5 H-IleArgArgGlnLysSerValMetProSerGluArgPheValGluProSerArg-28 35-ValHisGlyGlyLeuAspGlyAlaAlaGlyPheAspGluGlyGluArgValPhe-52 56-AlaAlaGlnAlaSerGlyAspGlyPheAla-65 79-GlnSerAspAlaAlaGlyAspPheGlyAspGlyGlnArgThrGlyGlu-94 96-ValLeuGlnAspValGlyGly-102 116-AlaGluGlyGluAlaGln-121 Hydrophilic Regions - Hopp-Woods H-IleArgArgGlnLysSerValMetProSerGluArgPheValGluProSerArg-28 43-AlaGlyPheAspGluGlyGluArgValPhe-52 81-AspAlaAlaGlyAspPheGlyAspGlyGlnArgThrGly-93 116-AlaGluGlyGluAlaGln-121 a046 AMPHI Regions - AMPHI 6-ArgProThrSerSerPro-ll 46-ThrSerCysSerGlyLeuMetValSer-54 64-PheSerLeuPheSerSer-69 113-LysSerAlaSerSer-117 143-SerCysAsnAlaPheSerSer-149 155-ThrSerLeuLeuGlyMetAlaAlaArgPheCysAlaThrVal-168 Antigenic Index - Jameson-Wolf 6-ArgProThrSerSerProProArgArgAlaCys-16 20-IleArgThrArgSerSerAlaLysArgLysThrCysAsnAlaProGlyGlnSerIleArgProAlaSerCysS er-44 57-ProAsnMetGluArgLeuPro-63 75-SerArgTyrSerLeuGluArgThrArgAlaMetArgProGlyMetLeuAsnArgSerAlaAla-95 105-SerLeuArgGluSerAlaSerSerLysSerAlaSerSerAlaProAlaArgSerAsnValLysGlyAspAla ProLeuProLysThrValTrpThrSerArgArgLeuProVal-142 169-GluProThrCysProLeuProLys-176 Hydrophilic Regions - Hopp-Woods 7-ProThrSerSerProProArgArgAlaCys-16 20-11eArgThrArgSerSerAlaLysArgLysThrCysAsn-32 36-GlnSerIleArgProAlaSer-42 58-AsnMetGluArgLeuPro-63 75-SerArgTyrSerLeuGluArgThrArgAlaMetArg-86 105-SerLeuArgGluSerAlaSerSerLysSerAlaSer-116 118-AlaProAlaArgSerAsnValLysGlyAspAlaProLeu-130 a047 AMPHI Regions - AMPHI 17-IleAlaAspIleAlaGlnAspLeuProAspGlyAla-28 62-AlaGluAsnIleGlyAlaVal-68 93-ArgLeuAlaLysGlnLeuGlu-99 141-TyrIleAspGluIleAspValPhe-148 161-SerAlaLeuLeuAla-165 185-LeuLeuGluGlyAsn-189 202-IleGlySerIleLeuAla-207 247-SerGlyIleLysTrpProGluGlyCys-255 257-IleAlaAlaValValArgAlaGlyThrGly-266 293-IleLeuAsnGluLeuGluLysLeuIle-301 Antigenic Index - Jameson-Wolf 5-GlnAlaArgArgGlyGlyLeuLeu-12 20-IleAlaGlnAspLeuProAspGlyAlaAsp-29 36-TyrArgAsnAsnArgLeu-41 51-IleGluGlyAspGlu-55 70-ProGluLeuArgProLysGluThrSerThrArgArgIleMet-83 86-GlyGlyGlyAsnIle-90 96-LysGlnLeuGluHis-100 106-IleIleGluCysArgProArgArgAlaGluTrpIle-117 119-GluAsnLeuAspAsnThrLeu-125 130-SerAlaThrAspGluThrLeuLeuAspAsnGluTyrIleAspGluIleAsp-146 152-ThrAsnAspAspGluSerAsnIle-159 168-LeuGlyAlaLysArgVal-173 178-AsnArgSerSerTyr-182 186-LeuGluGlyAsnLysIle-191 208-HisIleArgArgGlyAspIleVal-215 219-ProIleArgArgGlyThrAlaGluAlaIleGlu-229 232-AlaHisGlyAspLysLysThrSer-239 242-IleGlyArgArgIleSerGlyIleLysTrpProGluGlyCysHis-256 262-ArgAlaGlyThrGlyGluThr-268 277-ValIleGlnAspGlyAspHis-283 288-ValSerArgArgArgIleLeuAsnGluLeuGluLys-299 Hydrophilic Regions - Hopp-Woods 5-GlnAlaArgArgGlyGly-10 20-IleAlaGlnAspLeuProAspGlyAlaAsp-29 51-IleGluGlyAspGlu-55 70-ProGluLeuArgProLysGluThrSerThrArgArgIleMet-83 106-IleIleGluCysArgProArgArgAlaGluTrpIle-117 130-SerAlaThrAspGluThrLeuLeu-137 140-GluTyrIleAspGluIleAsp-146 152-ThrAsnAspAspGluSerAsnIle-159 168-LeuGlyAlaLysArgVal-173 186-LeuGluGlyAsnLysIle-191 209-IleArgArgGlyAspIle-214 219-ProIleArgArgGlyThrAlaGluAlaIleGlu-229 232-AlaHisGlyAspLysLysThrSer-239 242-IleGlyArgArgIleSer-247 277-ValIleGlnAspGlyAsp-282 289-SerArgArgArgIleLeuAsnGluLeuGluLys-299 a049-2 AMPHI Regions - AMPHI 15-GlnHisLeuLeuGlu-19 33-ThrAspAspThrValAspGlyIleGlyGlnMet-43 50-GlnProPheGlyGln-54 61-GluHisPheAlaProValAspGlyPheArg-70 79-HisGlnArgPhePhe-83 103-IleGlyValPheProAlaPhe-109 202-ArgGlyAlaGlyGlnArgArgValSerArgHisCys-213 217-AlaArgLeuThrGlnValPheGlnThrPhePhe-227 Antigenic Index - Jameson-Wolf 6-PheAspTyrArgThrArgLeu-12 20-LeuIleGlyLysAsnArgHis-26 29-LeuHisArgArgThrAspAspThrValAspGly-39 49-AspGlnProPheGly-53 64-AlaProValAspGlyPheArgValGlnAsnIleAspLeuAspGlyHisGlnArgPhePhe-83 90-PheArgAsnProValCysArgArgThrArgPheCys-101 122-GlyIleLysProAspSerProProArgPhe-131 135-PheArgAsnArgHisLeuGlnGlySerLeuArgVal-146 150-PheLeuLysAspAspHisArgValGly-158 182-GlnHisThrGlySer-186 193-ArgHisArgArgValArgSerGlyPheArgGlyAlaGlyGlnArgArgValSerArgHisCys-213 246-ArgGlnThrAsnProArgProLysArgGlyLeu-256 Hydrophilic Regions - Hopp-Woods 21-IleGlyLysAsnArgHis-26 31-ArgArgThrAspAspThrValAsp-38 72-GlnAsnIleAspLeuAspGlyHisGlnArgPhePhe-83 93 -ProValCysArgArgThrArgPheCys-101 124-LysProAspSerProProArg-130 150-PheLeuLysAspAspHisArgVa1-157 193-ArgHisArgArgValArgSerGlyPheArgGlyAlaGlyGlnArgArgValSerArg-211 246-ArgGlnThrAsnProArgProLysArgGlyLeu-256 a050-l AMPHI Regions - AMPHI lO-IleGlnSerIleCysAspAlaPheGlnPheIleSerTyrTyr-23 25-ProLysAspTyr11eAspAlaLeuTyrLysAlaTrpGlnLys-38 94-ValAsnGluGlyVal-98 163-AsnProSerAspAsnl1eValAspTrpValLeuLys-174 177-ProThrMetGlyAla-181 235-LeuGluLeuPheGluLysValAsnAla-243 250-GlyLeuGlyGlyLeuThrThr-256 275-AlaMetIleProAsn-279 302-ArgValGluAspTrpProAspLeuThr-310 315-AsnGlyLysArgValAspValAsp-322 353-LysArgLeuValAspMetLeuAspLys-361 367-ValAspPheThrAsnArgLeu-373 379-ProValAspProValGlyAspGlu-386 396-AlaThrArgMetAspLysPheThrArgGlnMet-406 410-ThrAspLeuLeuGlyMet-415 452-LysSerSerLysValLeuAlaPhe-459 Antigenic Index - Jameson-Wolf 4-IleLysGlnGluAspPheIle-10 23-TyrHisProLysAspTyrIleAspAlaLeu-32 36-TrpGlnLysGluGluAsnProAlaAlaLysAspAlaMet-48 55-SerArgMetCysAlaGluAsnAsnArgProIleCysGlnAspThrGly-70 88-MetSerValGluGluMetValAsnGluGlyValArgArgAlaTyrThrTrpGluGlyAsnThrLeuArgAlaS erVal-113 116-AspProAlaGlyLysArgGlnAsnThrLysAspAsnThr-128 137-ValProGlyAspLysValGluVal-144 146-CysAlaAlaLysGlyGlyGlySerGluAsnLysSerLysLeu-159 163-AsnProSerAspAsnIle-168 192-GlyIleGlyGlyThrProGluLysAlaValLeuMetAlaLysGluSerLeu-208 213-AspIleGlnGluLeuGlnGluLysAlaAlaSerGlyAlaGluLeuSerThr-229 284-ArgHisValGluPheGluLeuAspGlySerGlyProValGluLeuThrProProArgValGluAspTrpPro AspLeuThrTyrSerProAspAsnGlyLysArgValAspValAspLysLeuThrLysGluGluValAlaSer-331 345-LeuThrGlyArgAspAlaAlaHisLysArgLeuValAspMetLeuAspLysGlyGluGluLeuPro-366 379-ProValAspProValGlyAspGluIleValGlyProAlaGlyProThrThrAlaThrArgMetAspLysPhe ThrArgGlnMetLeuGluGlnThrAsp-411 417-GlyLysSerGluArgGlyAlaAlaThr-425 428-AlaIleAlaAspAsnLysAla-434 450-AlaIleLysSerSerLys-455 470-PheGluValLysAspMetPro-476 481-ValAspSerLysGlyGluSerIle-488 492-AlaProProGlnTrpGln-497 Hydrophilic Regions - Hopp-Woods 4-IleLysGlnGluAspPheIle-10 36-TrpGlnLysGluGluAsnProAlaAlaLysAspAlaMet-48 57-MetCysAlaGluAsnAsnArgProlleCys-66 88-MetSerValGluGluMetValAsnGluGlyValArgArg-100 117-ProAlaGlyLysArgGlnAsnThrLysAspAsnThr-128 138-ProGlyAspLysValGluVal-144 148-AlaLysGlyGlyGlySerGluAsnLysSerLysLeu-159 195-GlyThrProGluLysAlaValLeuMetAlaLysGluSerLeu-208 213-AspIleGlnGluLeuGlnGluLysAlaAlaSer-223 225-AlaGluLeuSerThr-229 284-ArgHisValGluPheGluLeuAspGly-292 299-ThrProProArgValGluAspTrpPro-307 313-ProAspAsnGlyLysArgValAspValAspLysLeuThrLysGluGluValAlaSer-331 345-LeuThrGlyArgAspAlaAlaHisLysArgLeuValAspMetLeuAspLysGlyGluGluLeuPro-366 382-ProValGlyAspGluIleVal-388 397-ThrArgMetAspLysPheThrArgGlnMetLeuGluGlnThrAsp-411 417-GlyLysSerGluArgGlyAlaAlaThr-425 428-AlaIleAlaAspAsnLysAla-434 450-AlaIleLysSerSerLys-455 470-PheGluValLysAspMetPro-476 481-ValAspSerLysGlyGluSerIle-488 a052 AMPHI Regions - AMPHI 40-AlaLysAlaSerLysSerAlaThrSerProLysGlyLeuAspGlyValSerLys-57 66-ThrAlaAlaPheHisSerPheIleSerValGlyAspThrLeuThrSerMetProAsnLeuValThrMetLeu- 89 Antigenic Index - Jameson-Wolf 4-ValAlaGluGluThrGluIle-10 14-CysPheLysGlyGluProThrGlyAspSerArgLeuLeuSerThrThrLysSerAlaPro-33 36-CysAlaAsnSerAlaLysAlaSerLysSerAlaThrSerProLysGlyLeuAspGlyValSerLysAsnSerS er-60 95-ValValProAsnArgLeuArgLeu-102 108-ProAlaCysLysLysValLysAsnAlaAla-117 Hydrophilic Regions - Hopp-Woods 4-ValAlaGluGluThrGluIle-10 15-PheLysGlyGluProThrGlyAspSerArgLeu-25 29-ThrLysSerAlaPro-33 38-AsnSerAlaLysAlaSerLysSerAlaThrSerProLysGlyLeuAspGlyValSerLysAsnSer-59 98-AsnArgLeuArgLeu-102 109-AlaCysLysLysValLysAsnAlaAla-117 a075 AMPHI Regions - AMPHI 19-LysThrProThrThrIleGlnProAlaSerIleProSer-31 65-AlaProTyrLeuArgGlnValLeu-72 80-PheLysLysCysLeuAla-85 116-AspPhePheGlnThrCysValAsnArgPhePheGluValValGluIleIleGlyIleGly-135 Antigenic Index - Jameson-Wolf 10-ThrMetGluLysThrLysSerAlaAlaLysThrProThr-22 25-GlnProAlaSerIlePro-30 52-AlaLysAlaArgGly-56 91-PhePheArgArgProProAsnIleArgLysSerValPheGlnLysSerGluTyrAspLys-110 Hydrophilic Regions - Hopp-Woods 10-ThrMetGluLysThrLysSerAlaAlaLysThr-20 52-AlaLysAlaArgGly-56 91-PhePheArgArgProProAsnl1eArgLysSerValPheGlnLysSerGluTyrAspLys-110 a080 AMPHI Regions - AMPHI 6-GluAlaMetGluArgLeuThrArg-13 95-PheProAspThrValGlu-100 108-ProValAlaArgTrpGlyAspHis-115 144-SerAlaGluMetLeuArgArgTyrAspGluPheSerThrValLeu-158 195-LysArgLeuArgLeuPheThrGluAlaTrpGlnHis-206 Antigenic Index - Jameson-Wolf l-MetTrpAspAsnAlaGluAlaMetGluArgLeuThr-12 33 -AsnSerAsnHisLeuPro-38 42-ValSerLeuLysGly-46 50-TyrSerAspLysLysAlaLeu-56 67-AsnIleLeuArgThrAspIleAsnGlyAlaGlnGluAlaTyr rg-81 90-MetValArgArgArgPheProAspThrValGlu-100 103-LeuThrGluArgLysProValAlaArgTrpGly-113 116-AlaLeuValAspGlyGluGlyAsnValPhe-125 127-AlaArgLeuAspArgProGlyMetPro-135 138-ArgGlyAlaGluGlyThrSer-144 146-GluMetLeuArgArgTyrAspGlu-153 163-LeuGlyIleLysGlu-167 187-ArgLeuGlyArgGluAsnGluMetLysArgLeuArgLeu-199 207-LeuLeuArgLysAsnLysAsnArgLeuSer-216 220-MetArgTyrLysAspGlyPheSer-227 230-TyrAlaProAspGlyLeuProGluLysGluSerGluGlu-242 Hydrophilic Regions - Hopp-Woods 3-AspAsnAlaGluAlaMetGluArgLeuThr-12 50-TyrSerAspLysLysAlaLeu-56 69-LeuArgThrAspIleAsnGlyAlaGlnGluAlaTyrArg-81 90-MetValArgArgArgPheProAspThrVal-99 103-LeuThrGluArgLysProValAlaArgTrpGly-113 116-AlaLeuValAspGlyGluGlyAsnValPhe-125 127-AlaArgLeuAspArgProGly-133 138-ArgGlyAlaGluGlyThrSer-144 146-GluMetLeuArgArgTyrAspGlu-153 163-LeuGlyIleLysGlu-167 187-ArgLeuGlyArgGluAsnGluMetLysArgLeuArgLeu-199 208-LeuArgLysAsnLysAsnArgLeuSer-216 220-MetArgTyrLysAspGlyPheSer-227 234-GlyLeuProGluLysGluSerGluGlu-242 a081 AMPHI Regions - AMPHI 22-LysProValSerArgIleValThrAspSer-31 86-ThrAlaLeuGlnMetLeuAlaLysAlaTrpArgGluAsn-98 116-LysGluMetLeuAlaAlaValLeuArgArg-125 135-ThrAlaGlyAsnPhe-139 165-MetAsnHisPheGlyGluLeuAlaValLeuThrGlnIleAlaLys-179 185-ValAsnAsnAlaMetArg-190 198-AspGlyValGlyAspIleAlaLysAla-206 303-LeuAsnAspValAlaGluGlyLeuLysGlyPheSerAsnIle-316 345-AlaAlaValAspValLeuAlaArgMetPro-354 360-ValMetGlyAspMetGlyGluLeuGlyGlu-369 399-ValGluAlaAlaGlu-403 Antigenic Index - Jameson-Wolf 16-ProMetProSerGluSerLysProValSer-25 27-IleValThrAspSerArgAspIleArgAlaGlyAsp-38 44-AlaGlyGlyArgPheAspAla-50 67-ValSerArgGluAspCysValAla-74 77-GlyAlaLeuLysValAspAspThrLeu-85 94-AlaTrpArgGluAsnValAsnProPhe-102 108-GlySerGlyGlyLysThrThrValLysGluMetLeu-119 123-LeuArgArgArgPheGlyAspAsnAlaVal-132 138-AsnPheAsnAsnHisIle-143 151-LysLeuAsnGluLysHisArg-157 178-AlaLysProAspAla-182 194-GlyCysGlyPheAspGlyValGlyAspIleAlaLysAlaLysSerGluIle-210 213-GlyLeuCysSerAspGly-218 223-ProGlnGluAspAlaAsn-228 239-LeuAsnThrArgThrPheGlyIleAspSerGlyAspValHisAla-253 280-ValProGlyArgHisAsnVal-286 305-AspValAlaGluGlyLeuLys-311 313-PheSerAsnIleLysGlyArgLeuAsnValLysSerGlyIleLysGly-328 330-ThrLeuIleAspAspThrTyrAsnAlaAsnProAspSerMetLysAlaAlaVal-347 363-AspMetGlyGluLeuGlyGluAspGluAlaAla-373 381-AlaTyrAlaArgAspGlnGlyIle-388 395-GlyAspAsnSerValGluAlaAlaGluLysPheGlyAla-407 422-LeuArgHisAspLeuProGluArgAlaThrVal-432 434-ValLysGlySerArg-438 443-GluGluValValGluAlaLeuGluAspLys-452 Hydrophilic Regions - Hopp-Woods 17-MetProSerGluSerLysProValSer-25 27-IleValThrAspSerArgAspIleArgAla-36 46-GlyArgPheAspAla-50 67-ValSerArgGluAspCysValAla-74 77-GlyAlaLeuLysValAspAspThrLeu-85 94-AlaTrpArgGluAsnVal-99 109-SerGlyGlyLysThrThrValLysGluMetLeu-119 123-LeuArgArgArgPheGlyAsp-129 151-LysLeuAsnGluLysHisArg-157 178-AlaLysProAspAla-182 199-GlyValGlyAspIleAlaLysAlaLysSerGluIle-210 223-ProGlnGluAspAlaAsn-228 247-AspSerGlyAspValHisAla-253 305-AspValAlaGluGlyLeuLys-311 316-IleLysGlyArgLeuAsnVal-322 335-ThrTyrAsnAlaAsnProAspSerMetLysAlaAlaVal-347 363-AspMetGlyGluLeuGlyGluAspGluAlaAla-373 381-AlaTyrAlaArgAspGlnGlyIle-388 397-AsnSerValGluAlaAlaGluLysPheGlyAla-407 422-LeuArgHisAspLeuProGluArgAlaThrVal-432 443-GluGluValValGluAlaLeuGluAspLys-452 a084-2 AMPHI Regions - AMPHI 6-ArgIleLysAsnMetAspGlnThrLeuLysAsnThrLeuGly-19 21-CysAlaLeuLeuAla-25 48-AlaValGlyAlaLeuAla-53 65-PheProArgValSer-69 96-GlnIleValGlySerIleLeuGluSer-104 lll-GluPheValGlyAsnLeuProGly-118 Antigenic Index - Jameson-Wolf l-MetLysGlnSerAlaArgIleLysAsnMetAspGlnThrLeuLysAsnThr-17 40-TyrGluTyrGlyTyrArgTyrSer-47 102-LeuGluSerAsnProAlaGluAlaArgGluPheValGly-114 139-ValSerGlyGlyGly-143 Hydrophilic Regions - Hopp-Woods l-MetLysGlnSerAlaArgIleLysAsnMetAspGlnThrLeu-14 105-AsnProAlaGluAlaArgGluPheVal-113 a085-2 AMPHI Regions - AMPHI 41-GluArgValSerGlnIleGlyLysMetPheAspGlyLeu-53 60-LeuLysAspAlaLeuSerAsnGlyPheAsp-69 89-ArgAsnGlyGlyArgValLeuGlyAspIleGluLeuLeuAlaAspIle-104 125-ThrSerLeuValGlyTyr-130 141-IleAlaGlyAsnIleGlyAla-147 174-GluAsnThrGluSerLeu-179 193-HisLeuAspArgTyrAspAspLeuLeuAspTyr-203 212-ArgGlyAspGlyValGln-217 225-PheCysArgAlaMetLysArgAla-232 275-HisAsnAlaThrAsnValMetAlaAlaValAlaLeuCysGluAla-289 300-HisValLysThrPheGlnGlyLeuProHisArgValGluLysIleGly-315 336-AlaAlaIleAlaGlyLeu-341 353 -GlyLysGlyGlnAspPheThr-359 395-AspCysAlaThrLeuGluGluAlaValGlnLysAla-406 424-SerPheAspMetPheLysGlyTyr-431 Antigenic Index - Jameson-Wolf 4-GlnAsnLysLysIleLeu-9 23-TyrLeuArgLysAsnGlyAlaGluValAlaAlaTyrAspAlaGluLeuLysProGluArgValSerGlnIleG lyLysMetPheAsp-51 58-GlyArgLeuLysAspAlaLeuSerAsnGly-67 74-SerProGlyIleSerGluArgGlnProAspIleGluAlaPheLysArgAsnGlyGlyArgValLeuGly-96 104-IleValAsnArgArgGlyAspLysValIle-113 116-ThrGlySerAsnGlyLysThrThr-123 150-LeuGluAlaGluLeuGlnArgGluGlyLysLysAlaAsp-162 169-ΞerSerPheGlnLeuGluAsnThrGluSerLeuArgProThrAla-183 189-IleSerGluAspHisLeuAspArgTyrAspAspLeuLeu-201 204-AlaHisThrLysAlaLysIlePheArgGlyAspGlyVal-216 220-AsnAlaAspAspAlaPheCysArgAlaMetLysArgAlaGlyArgGluValLys-237 247-PheTrpLeuGluArgGluThrGlyArgLeuLysGlnGlyAsnGluAspLeuIleAla-265 291-GlyLeuProArgGluAlaLeu-297 307-LeuProHisArgValGluLysIleGlyGluLysAsnGly-319 322-PhelleAspAspSerLysGlyThrAsnVal-331 351-GlyMetGlyLysGlyGlnAspPheThrProLeuArgAspAlaLeuAlaGlyLysAlaLys-370 378-AspAlaProGlnIleArgArgAspLeuAspGlyCysAspLeuAsnMetThrAspCysAlaThrLeuGluGlu AlaValGln-404 431-TyrAlaHisArgSer-435 Hydrophilic Regions - Hopp-Woods 4-GlnAsnLysLysIleLeu-9 25-ArgLysAsnGlyAlaGlu-30 32-AlaAlaTyrAspAlaGluLeuLysProGluArgValSerGln-45 59-ArgLeuLysAspAlaLeu-64 76-GlyIleSerGluArgGlnProAspIleGluAlaPheLysArgAsnGlyGly-92 104-IleValAsnArgArgGlyAspLysValIle-113 118-SerAsnGlyLysThrThr-123 150-LeuGluAlaGluLeuGlnArgGluGlyLysLysAlaAsp-162 174-GluAsnThrGluSerLeuArgPro-181 189-1leSerGluAspHiΞLeuAspArgTyrAspAspLeuLeu-201 204-AlaHisThrLysAlaLysIlePheArgGlyAspGly-215 220-AsnAlaAspAspAlaPheCysArgAlaMetLysArgAlaGlyArgGluValLys-237 247-PheTrpLeuGluArgGluThrGlyArgLeuLysGlnGlyAsnGluAspLeuIleAla-265 291-GlyLeuProArgGluAlaLeu-297 309-HisArgValGluLysIleGlyGluLysAsnGly-319 324-AspAspSerLysGlyThrAsn-330 353 -GlyLysGlyGlnAsp-357 359-ThrProLeuArgAspAlaLeuAlaGlyLysAlaLys-370 380-ProGlnIleArgArgAspLeuAspGlyCysAsp-390 397-AlaThrLeuGluGluAlaValGln-404 431-TyrAlaHisArgSer-435 a086 AMPHI Regions - AMPHI 55-MetArgThrTrpArgArgLeuValPro-63 83-IleAsnGlyAlaThrArg-88 99-ProThrGluLeuPheLysLeuAlaVal-107 120-GluValLeuArgSerMetGluSerLeuGlyTrpGlnSerIleTrpArgGlyThrAlaAsn-139 155-GluMetTyrGlyArgPhe-160 185-SerPheValValIle-189 228-ArgValGlnArgValValAlaPheLeuAspProTrpLysAspProGln-243 293-GlyPhePheGlyMetCys-298 336-TrpIleGlyIleGlnSerPhe-342 Antigenic Index - Jameson-Wolf 20-LeuAlaSerLysGluGlyGlyAsp-27 55-MetArgThrTrpArgArg-60 79-AlaGlyArgGluIleAsnGlyAlaThr-87 115-PheThrArgArgGluGluValLeuArgSerMetGlu-126 134-TrpArgGlyThrAla-138 144-AlaThrAsnProGlnAlaArgArgGluThrLeuGluMet-156 225-AlaProTyrArgVal-229 236-LeuAspProTrpLysAspProGlnGlyAla-245 265-GlyLeuGlyAlaSerLeuSerLysArgGlyPheLeu-276 313-SerIleGlyLysGlnSerArgAspLeuGly-322 352-LeuProThrLysGlyLeu-357 382-IleAspTyrGluAsnArgArgLysMetArgGlyTyrArgValGlu-396 Hydrophilic Regions - Hopp-Woods 21-AlaSerLysGluGlyGlyAsp-27 79-AlaGlyArgGluIleAsnGly-85 115-PheThrArgArgGluGluValLeuArgSerMetGlu-126 147-ProGlnAlaArgArgGluThrLeuGluMet-156 238-ProTrpLysAspProGlnGly-244 270-LeuSerLysArgGlyPheLeu-276 316-LysGlnSerArgAspLeu-321 382-IleAspTyrGluAsnArgArgLysMetArgGlyTyrArgValGlu-396 a087 AMPHI Regions - AMPHI 23-ValAlaAspSerLeuArg-28 80-GlnThrValArgGluAlaGlnGlnIle-88 99-GlyPheGlyGlyPheValThrPheProGlyGlyLeuAlaAlaLysLeuLeu-115 129-GlyLeuSerAsnArgHisLeuSerArgTrpAlaLysArgValLeuTyrAlaPheProLys-148 157-ValGlyAsnProValArg-162 192-GlyAlaAspValLeuAsnLysThrVal-200 239-GluCysValGluPheIleThrAspMetValSerAlaTyr-251 313-GluLysLeuAlaGluIleLeuGly-320 330-TrpAlaGluAsnAla-334 Antigenic Index - Jameson-Wolf 25-AspSerLeuArgAlaArgGly-31 37-LeuGlySerLysAspSerMetGluGluArgIleValPro-49 61-LysGlyValArgGlyAsnGlyIleLysArgLysLeu-72 81-ThrValArgGluAlaGlnGlnIleIleArgLysHisArgVal-94 130-LeuSerAsnArgHisLeuSerArgTrpAlaLys-140 150-PheSerHisGluGlyGlyLeu-156 159-AsnProValArgAlaAspIleSer-166 171-ProAlaGluArgPheGlnGlyArgGluGlyArgLeu-182 195-ValLeuAsnLysThrVal-200 207-LeuProAspAsnAlaArgProGlnMetTyrHisGlnSerGlyArgGlyLysLeuGly-225 229-AlaAspTyrAspAla-233 249-SerAlaTyrArgAspAlaAsp-255 284-AlaValAspAspHisGlnThrAla-291 309-GlnLeuThrAlaGluLysLeuAlaGlu-317 321-GlyLeuAsnArgGluLysCysLeuLys-329 331-AlaGluAsnAlaArgThr-336 341-HisSerAlaAspAspValAlaGlu-348 Hydrophilic Regions - Hopp-Woods 25-AspSerLeuArgAlaArgGly-31 39-SerLysAspSerMetGluGluArgIleValPro-49 66-AsnGlyIleLysArgLysLeu-72 81-ThrValArgGluAlaGlnGlnIleIleArgLysHisArgVal-94 134-HisLeuSerArgTrpAlaLys-140 161-ValArgAlaAspIle-165 171-ProAlaGluArgPheGlnGlyArgGluGlyArgLeu-182 219-SerGlyArgGlyLysLeu-224 249-SerAlaTyrArgAspAlaAsp-255 284-AlaValAspAspHisGlnThrAla-291 310-LeuThrAlaGluLysLeuAlaGlu-317 322-LeuAsnArgGluLysCysLeuLys-329 331-AlaGluAsnAlaArg-335 341-HisSerAlaAspAspValAlaGlu-348 a088-2 AMPHI Regions - AMPHI 7-HisPheSerAsnTrpLeuThrGlyLeuAsnIlePheGlnTyrThrThr-22 24-ArgAlaValMetAlaAlaLeu-30 43-ThrIleArgArgLeuThrAlaLeuLysCysGlyGln-54 88-LeuTrpGlyAsnTrpAlaAsn-94 111-GlyPheTyrAspAspTrpArgLysValValTyr-121 140-AlaIleIleAlaGlyLeuAlaLeu-147 175-GlyPheLeuValLeuSerTyrLeuThrIle-184 187-ThrSerAsnAlaValAsnLeuThrAspGlyLeuAspGlyLeuAlaThr-202 221-HisSerGlnPheAlaGlnTyrLeuGlnLeuProTyr-232 245-AlaMetCysGlyAlaCysLeuGlyPhe-253 Antigenic Index - Jameson-Wolf 48-ThrAlaLeuLysCysGlyGlnAlaValArgThrAspGlyProGln-62 66-ValLysAsnGlyThrProThrMet-73 114-AspAspTrpArgLysValValTyrLysAspProAsnGlyValSerAlaLysPhe-131 193-LeuThrAspGlyLeuAsp-198 312-LysLysThrLysLysArgIle-318 328-TyrGluGlnLysGlyTrpLysGluThrGlnVal-338 Hydrophilic Regions - Hopp-Woods 56-ValArgThrAspGlyProGln-62 114-AspAspTrpArgLysValValTyrLysAspProAsnGlyVal-127 312-LysLysThrLysLysArgIle-318 331-LysGlyTrpLysGlu-335 a089 AMPHI Regions - AMPHI 44-CysGlyArgProXxxLysVal-50 73-ThrLeuValAlaLeuCysLysProCysSerGlyIle-84 118-SerArgProAlaArgPhe-123 Antigenic Index - Jameson-Wolf 1-MetProProLysIleThrLysSerGlyPhe-lO 40-PheSerThrArgCysGlyArgProXxxLys-49 54-SerSerAsnAlaSerArgGlyLysProThrAlaSerHisLysAla-68 80-ProCysSerGlyIle-84 95-CysPheArgArgProValSerArgSerAsnGlnLysSerAlaSerTyrSerAsnGluAsnHisPheThrSerA rgProAlaArgPhelleAlaArgGlnAsnAlaSerSerAlaPheLysThrCysThrProSerProArgLysIleLe u-144 Hydrophilic Regions - Hopp-Woods 43 -ArgCysGlyArgProXxxLys-49 56-AsnAlaSerArgGlyLysProThrAlaSerHisLysAla-68 95-CysPheArgArgProValSerArgSerAsnGlnLysSerAlaSerTyrSerAsn-112 119-ArgProAlaArgPheIleAla-125 137-ThrProSerProArgLysIle-143 a090-l AMPHI Regions - AMPHI 10-SerGlnSerLeuLysArgProAspLysHisPheArg-21 142-AspPhePheHisAlaValArgGlnAlaLeuLysGlyPheAspValPheGluGlnCysPheAla-162 164-GlnThrAspGlyPhe-168 177-ValSerGlyValValGlnAlaLeuGlnArg-186 226-LeuHisArgThrThrGluArgIleValArgIleGlnAsnLeuHisThrVal-242 253-ValValGluGlnVal-257 268-ValGlnHisCysArgArgSerArg-275 381-GlyAlaGluCysGlnAsnIleGluThrValGlyGluArg-393 404-ProValLysHisLeuThrAspLeuArg-412 425-AsnLeuArgAlaValPheAlaGlnValGlyAsnHisGlyAsnThrArgAlaAlaLysSer-444 Antigenic Index - Jameson-Wolf 9-ValSerGlnSerLeuLysArgProAspLysHisPheArg-21 29-HisIleGluThrArgAlaGlyGlyAlaGluGlnHisAspIleAla-43 56-PheGlnSerGlyAla-60 73-AlaAspLeuArgArgl1eAspThrAspGlnGluHis-84 89-AlaGlyLysArgValAlaGlnGlyArgGluVal-99 107-XxxAsnHisGluGluArgIleLeuGlnThrGlyAsnArgGlyGlyGlyArgThrAspValArg-127 149-GlnAlaLeuLysGlyPheAsp-155 161-PheAlaArgGlnThrAspGlyPheAlaGlnGlyAsnGlySerHisHisValSer-178 187-AsnIleLeuArgGlyAsnGln-193 215-GlnArgLysProPheHisLeuAla-222 228-ArgThrThrGluArgIleValArg-235 269-GlnHisCysArgArgSerArgAlaGln-277 285-GluThrGlyLysLeuGlnHis-291 305-LeuGlnAsnArgArgAlaAspIleAlaArgAspAsnGlyIle-318 320-ProThrLeuAspAlaGluIleAlaAspGlnAlaArgTyrArgGly-334 339-AlaGlyAsnArgAsnHis-344 353-ValArgGlnGlnPhe-357 369-LysGlyLeuAspIle-373 380-AlaGlyAlaGluCysGlnAsn-386 398-AlaArgValLysHisGlnProVal-405 407-HisLeuThrAspLeuArgHis-413 421-IleIleArgSerAsnLeuArg-427 434-GlyAsnHisGlyAsnThrArgAlaAlaLysSerGlyAspGluAspPhePhe-450 Hydrophilic Regions - Hopp-Woods ll-GlnSerLeuLysArgProAspLysHisPheArg-21 29-HisIleGluThrArgAlaGlyGlyAlaGluGlnHisAspIleAla-43 73-AlaAspLeuArgArgIleAspThrAspGlnGluHis-84 89-AlaGlyLysArgValAlaGlnGlyArgGluVal-99 107-XxxAsnHisGluGluArgIleLeu-114 117-GlyAsnArgGlyGlyGlyArgThrAspValArg-127 228-ArgThrThrGluArgIleValArg-235 269-GlnHisCysArgArgSerArgAla-276 285-GluThrGlyLysLeuGln-290 305-LeuGlnAsnArgArgAlaAspIleAlaArgAspAsnGlyIle-318 322-LeuAspAlaGluIleAlaAspGlnAlaArgTyrArg-333 369-LysGlyLeuAspIle-373 380-AlaGlyAlaGluCysGlnAsn-386 398-AlaArgValLysHisGlnPro-404 409-ThrAspLeuArgHis-413 421-IleIleArgSerAsnLeu-426 437-GlyAsnThrArgAlaAlaLysSerGlyAspGluAspPhePhe-450 a091 AMPHI Regions - AMPHI 39-ProLeuSerAspGlyIleAlaSerCys-47 49-IleThrArgPheGlnAlaLeuVal-56 61-ValLeuValSerValLeuThrSerLeuAlaLys-71 Antigenic Index - Jameson-Wolf 5-ValProProSerProAlaThr-ll 38-LysProLeuSerAspGlyIleAla-45 a092 AMPHI Regions - AMPHI 55-GlyMetSerGlyIleAlaGluValLeuHis-64 76-AlaArgAsnAlaAlaThrGluHisLeu-84 95-HisThrAlaGluHisValAsnGly-102 120-ValAlaAlaLeuGlu-124 137-AlaGluLeuMetArgPheArgAsp-144 209-LeuThrProIleMetSerValValThrAsnIleAsp-220 226-ThrTyrGlyHisSerValGluLysLeuHisGlnAlaPheIleAspPheIleHisArg-244 259-HisValArgAlaIleLeuProLysValSerLysProTyr-271 273-ThrTyrGlyLeuAspAspThrAla-280 321-AsnValLeuAsnAlaLeuAlaAlaIle-329 339-ValGluAlaIleGlnLysGly-345 353-GlyArgArgPheGlnLysTyrGlyAspIleLys-363 407-ArgTyrThrArgThrArgAspLeuPheGluAspPheThrLysValLeuAsnThrValAspAlaLeu-42! 449-LeuAlaArgAlaIleArgValLeuGlyLysLeu-459 464-CysGluAsnValAlaAspLeuProGluMetLeuLeuAsn-476 Antigenic Index - Jameson-Wolf 14-LeuTrpArgAlaAsnGlyGlnProPheLys-23 25-ThrProLeuArgIleGluAsnProProGluArgAsnIleMetMetLysAsnArgVal-43 70-ValSerGlySerAspGlnAlaArgAsnAlaAla-80 lll-AlaValLysLysGluAsnProGluVal-119 140-MetArgPheArgAspGlyIle-146 150-GlyThrHisGlyLysThrThrThr-157 184-GlyThrAsnAlaArgLeuGlyLysGlyGluTyr-194 198-GluAlaAspGluSerAspAla-204 218-AsnIleAspGluAspHisMetAspThrTyrGly-228 230-SerValGluLysLeuHis-235 255-IleAspSerGluHisVal-260 263-IleLeuProLysValSerLysProTyrAla-272 275-GlyLeuAspAspThrAlaAsp-281 286-AspIleGluAsnValGlyAla-292 302-MetLysGlyHisGluGlnGlySerPhe-310 351-GlyValGlyArgArgPheGlnLysTyrGlyAspIleLysLeuProAsnGlyGly-368 374-AspAspTyrGlyHisHisPro-380 393-AlaTyrProGluLysArgLeu-399 404-GlnProHisArgTyrThrArgThrArgAspLeuPheGluAspPheThrLys-420 435-AlaAlaGlyGluGluProIleAlaAlaAlaAspSerArgAlaLeuAlaArg-451 466-AsnValAlaAspLeuPro-471 478-LeuGlnAspGlyAspIle-483 488-GlyAlaGlySerIleAsn-493 Hydrophilic Regions - Hopp-Woods 26-ProLeuArgIleGluAsnProProGluArgAsnIleMetMetLysAsnArgVal-43 71-SerGlySerAspGlnAlaArgAsnAlaAla-80 lll-AlaValLysLysGluAsnProGlu-118 140-MetArgPheArgAsp-144 152-HisGlyLysThrThr-156 187-AlaArgLeuGlyLysGlyGlu-193 198-GluAlaAspGluSerAspAla-204 218-AsnIleAspGluAspHisMetAsp-225 230-SerValGluLysLeuHis-235 256-AspSerGluHisVal-260 275-GlyLeuAspAspThrAlaAsp-281 303-LysGlyHisGluGlnGlySer-309 351-GlyValGlyArgArgPheGlnLys-358 360-GlyAspIleLysLeu-364 393-AlaTyrProGluLysArgLeu-399 407-ArgTyrThrArgThrArgAspLeuPheGluAspPheThrLys-420 435-AlaAlaGlyGluGluProIleAlaAlaAlaAspSerArgAlaLeuAlaArg-451 466-AsnValAlaAspLeuPro-471 479-GlnAspGlyAspIle-483 a093-2 AMPHI Regions - AMPHI 26-ThrAlaIleLeuAsn-30 59-ThrAlaPheAsnIleLeuHisGly-66 159-LysSerValTyrGluGluLeuLysHisPhe-168 196-IleHisIleIleProAlaThrGluPhe-204 254-PheLeuLysAspThr-258 267-IleAsnThrLeuProGlyMetThrGly-275 Antigenic Index - Jameson-Wolf 12-GlyGlyPheSerSerGluArgGluIleSerLeuAspSerGlyThr-26 32-LeuLysSerLysGlyIleAsp-38 41-AlaPheAspProLysGluThrProLeuSerGluLeuLysAlaGlnGly-56 66-GlyThrTyrGlyGluAspGlyAlaVal-74 96-GlyMetAspLysTyrArgCys-102 120-HisAspAspThrAspPheAspAlaValGluGluLysLeuGly-133 140-ProAlaAlaGluGlySerSer-146 151-LysValLysGlyLysGlyArgLeuLysSerValTyrGluGluLeuLysHisPheGln-169 176-ArgPheIleGlyGlyGlyGluTyrSer-184 189-AsnGlyLysGlyLeuPro-194 203-GluPheTyrAspTyrGluAlaLysTyrAsnArgAsnAspThr-216 218-TyrGlnCysProSerGluAspLeuThrGluAlaGluGluSerLeuMetArg-234 245-GlyAlaGluGlyCysVal-250 253-AspPheLeuLysAspThrAspGly-260 269-ThrLeuProGlyMetThr-274 Hydrophilic Regions - Hopp-Woods 15-SerSerGluArgGluIleSerLeu-22 32-LeuLysSerLysGlyIleAsp-38 41-AlaPheAspProLysGluThrProLeuSerGluLeuLysAla-54 68-TyrGlyGluAspGlyAlaVal-74 96-GlyMetAspLysTyrArgCys-102 120-HisAspAspThrAspPheAspAlaValGluGluLysLeuGly-133 140-ProAlaAlaGluGlySerSer-146 151-LysValLysGlyLysGlyArgLeuLysSerValTyrGluGluLeuLysHisPheGln-169 205-TyrAspTyrGluAlaLysTyrAsnArgAsnAspThr-216 221-ProSerGluAspLeuThrGluAlaGluGluSerLeuMetArg-234 253-AspPheLeuLysAspThrAspGly-260 a094 AMPHI Regions - AMPHI 17-LeuProProIleThrLysValGlySer-25 80-PheSerPheLeuThrAlaVal-86 Antigenic Index - Jameson-Wolf 3-SerProLeuProLysArgAlaLeu-10 24-GlySerSerProAlaAlaProArgMetGluAla-34 50-MetProSerArgLysArgIleAsnSerAlaAsnIleArgAlaArgGlyIleThr-67 Hydrophilic Regions - Hopp-Woods 5-LeuProLysArgAlaLeu-10 28-AlaAlaProArgMetGluAla-34 51-ProSerArgLysArglleAsn-57 60-AsnIleArgAlaArgGly-65 a095-2 AMPHI Regions - AMPHI 9-CysAlaSerAsnLeuPheArgGlnPheGlnGlnArgGlyGlyAspAlaValAsp-26 38-ValLeuGlnAsnValGlnGlnHisPheGlyGlnIleGlyAsnValPheAlaVal-55 86-PheGlyGlnHiSGlnArgValAsnGlyIleGluAspPheGlyLysValPheLysGlnlleAlaArg-107 132-GlyArgArgHisPheAspGlyValValSer-141 174-PheLeuAspArgPheAsnArgCysAlaAspPheGlnArgHisAlaAspGlyCysGlnCysValGlnHisVal -197 204-GlnHisAspPheLys-208 236-AspValGlyGlyIleValGlnThrValSerSerIle-247 274-ThrValAspGluIleAspLysArgLeuMetGlnLeuLeuAsnThrVal-289 313-GlyCysIleArgLeuValGly-319 370-AsnGlyAspAlaValThrGluAlaHisGlnLeuArgGlnHisGlnGlyAla-386 417-ValAsnValPheCysGly-422 435-MetLeuGlySerGlyIleSerArgLeuIleArgThrGly-447 451-ThrGlnIleValGlnAspPheGlyAspThrAlaHisAla-463 Antigenic Index - Jameson-Wolf 6-SerGlyGlyCysAlaSerAsnLeu-13 17-PheGlnGlnArgGlyGlyAspAlaValAspAlaSerArgThrHisIle-32 62-GlnHisAlaAspGlyAlaGlyLysSerAlaGlyIleSerGlyGlyAsnArgLeuPhe-80 88-GlnHisGlnArgValAsnGlyIleGluAspPheGlyLys-100 112ValArgLeuGluGlyGluTyr-118 126-AlaAlaCysGlyGlyLysGlyArgArgHisPheAspGly-138 144-ValHisGlnGluArgGlySerThr-151 163-AlaAlaAlaAspThrPheLysAlaGluGlnAlaPhe-174 176-AspArgPheAsnArgCysAlaAspPheGlnArgHisAlaAspGlyCysGln-192 205-HisAspPheLysArg-209 253-GlyGlnAsnArgAlaAspVal-259 263-AsnThrGlnLysGlyPheAlaVal-270 273-HisThrValAspGluIleAspLysArgLeu-282 300-IleGlyAsnAspGlyHisAsnArgCysGlnValGlnLysGlyCys-314 339-PheAlaAlaAspAsnGluSerArgValLysSerCysArgAlaGluAspGlyGlyGlyGlnAlaGlyGlyArg GlyPheAlaValArgAlaGlyAsnGlyAspAlaValThr-375 378-HisGlnLeuArgGlnHisGlnGlyAlaArgAsnAsnGlyAsn-391 394-LeuGlnArgSerAspAsnPheGly-401 405-PheAspGlyGlyArgGlyAsnAspAspI1eArgThr-416 442-ArgLeuIleArgThrGlyAsnPheLysThr-451 455-GlnAspPheGlyAspThrAlaHisAlaAspAlaAlaAspThrAspLysMetAspVal-473 Hydrophilic Regions - Hopp-Woods 17-PheGlnGlnArgGlyGlyAspAlaValAspAlaSerArgThrHisIle-32 64-AlaAspGlyAlaGlyLysSerAlaGly-72 93-AsnGlyIleGluAspPheGlyLys-100 112-ValArgLeuGluGlyGluTyr-118 128-CysGlyGlyLysGlyArgArgHisPhe-136 145-HisGlnGluArgGlySer-150 163-AlaAlaAlaAspThrPheLysAlaGluGlnAlaPhe-174 182-AlaAspPheGlnArgHisAlaAspGly-190 205-HisAspPheLysArg-209 273-HisThrValAspGluIleAspLysArgLeu-282 300-IleGlyAsnAspGlyHisAsnArgCysGlnVal-310 339-PheAlaAlaAspAsnGluSerArgValLysSerCysArgAlaGluAspGlyGlyGly-357 368-AlaGlyAsnGlyAspAlaValThr-375 378-HisGlnLeuArgGlnHisGlnGlyAlaArgAsnAsnGly-390 395-GlnArgSerAspAsn-399 407-GlyGlyArgGlyAsnAspAspIleArgThr-416 461-AlaHisAlaAspAlaAlaAspThrAspLysMetAspVal-473 a096-2 AMPHI Regions - AMPHI 19-GlyIlePheGluGluIleAspAlaHis-27 37-AlaAlaAsnArgGln-41 61-GlyValValAlaVal-65 112-GlnPhePheValAsnAlaPheGln-119 129-AlaTyrAlaAlaAlaPheGlyArg-136 172-AsnGlnPheAlaAla-176 187-AspThrAlaAlaGlyIleGlyAsnAlaGln-196 228-GlnTrpGlyPheLeu-232 Antigenic Index - Jameson-Wolf 4-HisThrGlyGlnGly-8 22-GluGluIleAspAla-26 30-PheArgThrAspCysLeuArgAlaAlaAsn-39 73-LysLeuGlyArgGlyAspAspValTyrAla-82 97-AlaAlaAspLysProPheGlyAsnAspPhe-106 137-ArgPheHisLysHisArgGln-143 157-ValGlnAspGlyGluLeuGlyAsnGlyGlnSerGlnCysLeu-170 181-AlaAspGlyGlyCysGlyAspThr-188 211-ThrValLysAspValGluCysArgLeu-219 Hydrophilic Regions - Hopp-Woods 22-GluGluIleAspAla-26 33-AspCysLeuArgAlaAlaAsn-39 74-LeuGlyArgGlyAspAspValTyr-81 97-AlaAlaAspLysProPheGly-103 137-ArgPheHisLysHisArgGln-143 158-GlnAspGlyGluLeuGlyAsn-164 183-GlyGlyCysGlyAspThr-188 211-ThrValLysAspValGluCysArgLeu-219 a097 AMPHI Regions - AMPHI 28-AlaGlyLeuThrThrPheLeuThrMetCysTyrIleVal-40 72-MetGlyPheValGly-76 166-AlaThrLeuValGlyLeuGlyAspIleHisGlnProSerAlaLeuLeuAlaLeuPheGly-185 207-ThrIleThrValIleAlaSerLeuMetGlyLeuAsnGluPheHisGlyIleIleGlyGluValProSerIle -230 242-LeuPheThrValSer-246 260-PheAspSerThrGlyThr-265 342-LeuAlaLysSerValProAlaPheAlaThr-351 362-MetLeuArgSerAlaArgAspIle-369 Antigenic Index - Jameson-Wolf l-MetAspThrSerLysGlnThrLeu-8 13-PheLysLeuLysAlaAsnGlyThrThrValArgThrGluLeu-26 125-LysValArgGluMetLeu-130 260-PheAspSerThrGly-264 277-ValAspGlyLysLeuProArgLeuLysArg-286 317-SerAlaGlyGlyArgThrGly-323 364-ArgSerAlaArgAspIleAspTrpAspAspMetThrGlu-376 410-LeuCysArgArgThrLysAspValProPro-419 Hydrophilic Regions - Hopp-Woods l-MetAspThrSerLys-5 16-LysAlaAsnGlyThrThrValArgThrGluLeu-26 125-LysValArgGluMetLeu-130 279-GlyLysLeuProArgLeuLysArg-286 318-AlaGlyGlyArgThr-322 364-ArgSerAlaArgAspIleAspTrpAspAspMetThrGlu-376 410-LeuCysArgArgThrLysAspValPro-418 a098-2 AMPHI Regions - AMPHI 28-AlaAlaGluAlaGlyGluGlnPheValGlyAsp-38 110-ValGlyAspPhePheLysLeuAlaPhe-118 120-CysGlnIleGlnAsnValValThrAlaIleAlaGlnIleValAla-134 163-LeuSerSerPheSerHisGly-169 Antigenic Index - Jameson-Wolf 24-ValGlnGluAspAlaAlaGluAlaGlyGlu-33 68-MetGlyMetCysArg-72 78-PheAsnHisThrAspArgGlnAlaAla-86 136-ThrAlaAsnGlyThrGlnSerGlyIleThrGlyArgAsnAlaArgLysArgAsnGlyPhe-155 158-PheGluGlyArgGlyLeuSerSerPheSerHisGlyIle-170 180-ValPheArgArgProMetArgIleCys-188 Hydrophilic Regions - Hopp-Woods 24-ValGlnGluAspAlaAlaGluAlaGlyGlu-33 79-AsnHisThrAspArgGlnAla-85 144-IleThrGlyArgAsnAlaArgLysArgAsnGly-154 158-PheGluGlyArgGly-162 180-ValPheArgArgProMetArg-186 a099 AMPHI Regions - AMPHI 6-SerMetMetArgLeuProAspI1e-13 47-AlaPheValGluPhePheGlyGluGly-55 102-LysLeuValGluThrTyrAlaLysThr-110 114-TrpAlaAspAlaLeuLysThrAla-121 135-ThrArgAsnMetAlaGlyProSerAsn-143 154-AlaGlyLysGlyLeuAlaLysProTyrGluGluProSerAspGlyGln-169 178-AlaAlaIleThrSerCysThrAsnThrSerAsnProArgAsnVal-192 251-ThrCysAsnGlyMetSer-256 341-IleAspAlaIleValAlaGluTyr-348 350-LysProGlnGlnPheArgAspVal-357 371-ProSerProLeuTyrAspTrpArg-378 381-SerThrTyrIleArg-385 400-LeuSerGlyMetArgProLeu-406 443-AspPheAsnSerTyrAlaThr-449 468-PheAsnGluMetValArg-473 494-MetArgMetTrpGluAlaIleGluThrTyrMet-504 532-ArgLeuAlaGlyVal-536 539-IleValAlaGluGlyPheGluArgIleHisArgThrAsn-551 575-GlyThrGluThrTyr-579 Antigenic Index - Jameson-Wolf 18-LeuAsnGlyLysArgLysAlaGly-25 38-PheLeuArgLysGluArgValVal-45 53-GlyGluGlyAlaArgSer-58 60-SerIleGlyAspArgAlaThr-66 70-MetThrProGluPhe-74 83-IleAspGluGlnThr-87 94-ThrGlyArgAspAspAlaGlnValLysLeu-103 133-SerValThrArgAsnMetAlaGlyProSerAsnProHis-145 153-LeuAlaGlyLysGlyLeuAlaLysProTyrGluGluProSerAspGlyGlnMetProAspGlyAla-174 183-CysThrAsnThrSerAsnProArgAsnVal-192 206-GlyLeuGlnArgLysProTrpValLysSerSerPheAlaProGlySerLysValAla-224 227-TyrLeuLysGluAlaAspLeuLeuProGluMetGluLysLeu-240 251-ThrCysAsnGlyMetSerGlyAlaLeuAspProLysIleGlnLysGluIleIleAspArgAspLeuTyr-27 3 279-SerGlyAsnArgAsnPheAspGlyArgIleHisProTyrAlaLys-293 312-IleArgPheAspIleGluAsnAspVal-320 322-GlyValAlaAspGlyLysGluIleArgLeuLysAspIleTrpProThrAspGluGluIleAsp-342 348-TyrValLysProGlnGlnPheArgAsp-356 363-AspThrGlyThrAlaGlnLysAlaProSerProLeuTyrAspTrpArgProMetSerThrTyrIleArgArg ProProTyrTrp-390 394-LeuAlaGlyGluArgThrLeuSerGlyMetArg-404 409-LeuProAspAsnIleThrThrAspHisLeuSerProSerAsn-422 438-GlyLeuProGluGluAspPheAsnSerTyrAlaThrHisArgGlyAspHisLeuThr-456 463-AlaAsnProLysLeuPhe-468 471-MetValArgAsnGluAspGlySerValArgGlnGlySerLeuAlaArgValGluProGluGlyGlnThr-49 3 503-TyrMetAsnArgLysGlnPro-509 516-AlaAspTyrGlyGlnGlySerSerArgAspTrpAlaAlaLysGlyValArg-532 543-GlyPheGluArgIleHisArgThrAsnLeu-552 562-PheLysProGlyThrAsnArgHisThrLeuGlnLeuAspGlyThrGluThrTyrAspValValGlyGluArg ThrProArgCysAspLeu-591 595-IleHisArgLysAsnGlyGluThrValGlu-604 609-CysArgLeuAspThrAlaGluGlu-616 Hydrophilic Regions - Hopp-Woods 18-LeuAsnGlyLysArgLysAlaGly-25 38-PheLeuArgLysGluArgValVal-45 53-GlyGluGlyAlaArg-57 60-SerIleGlyAspArgAlaThr-66 83-IleAspGluGlnThr-87 94-ThrGlyArgAspAspAlaGlnValLysLeu-103 157-GlyLeuAlaLysProTyrGluGluProSerAspGlyGlnMetPro-171 227-TyrLeuLysGluAlaAspLeuLeuProGluMetGluLysLeu-240 259-LeuAspProLysIleGlnLysGluIleIleAspArgAspLeuTyr-273 282-ArgAsnPheAspGlyArgIle-288 312-IleArgPheAspIleGluAsnAspVal-320 324-AlaAspGlyLysGluIleArgLeuLysAsp-333 335-TrpProThrAspGluGluIleAsp-342 366-ThrAlaGlnLysAlaPro-371 394-LeuAlaGlyGluArgThrLeuSer-401 438-GlyLeuProGluGluAspPheAsn-445 450-HisArgGlyAspHisLeuThr-456 471-MetValArgAsnGluAspGlySerValArgGln-481 485-AlaArgValGluProGluGlyGlnThr-493 503-TyrMetAsnArgLysGlnPro-509 518-TyrGlyGlnGlySerSerArgAspTrpAlaAlaLysGlyValArg-532 543-GlyPheGluArgIleHisArg-549 564-ProGlyThrAsnArgHis-569 574-AspGlyThrGluThr-578 580-AspValValGlyGluArgThrProArgCysAsp-590 595-IleHisArgLysAsnGlyGluThrValGlu-604 609-CysArgLeuAspThrAlaGluGlu-616 al02 AMPHI Regions - AMPHI 42-ValLeuLeuTyrThrTrpPheSerMetLeu-51 67-GlyAlaXxxPheAspThrMetValLysAspLeuLeuGlyArgSerTrpAsnIleIleAsnGlyIleAla-89 109-ThrAlaLysGlyLeuGlySerAlaAla-117 128-LeuValPhePheGlyIleLeuAlaPheCys-137 144-LeuValAspArgPheThrSerValLeu-152 155-GlyMetValLeuThr-159 207-AsnValSerSerLeuLeuLysTyrPheLys-216 221-LysValAlaLysSerIle-226 267-IleGluThrLeuSerLysPheAlaGlnThrGlyAsnMetAspLysIleLeuSerLeuPheSerTyrMetAla -290 303-PheAspTyrIleAlaAspIlePheLysTrpAsnAsp-314 341-PheValThrAlaIleGlyTyr-347 352-AlaThrValTrpThrGlyIleIlePro-360 374-GlyLysThrTyrLysVal-379 Antigenic Index - Jameson-Wolf l-MetProThrLysThrProSerLeu-8 77-LeuLeuGlyArgSer-81 107-AspLeuThrAlaLysGlyLeuGlySerAlaAlaGlyGly-119 143-ArgLeuValAspArgPheThr-149 179-ThrGlnAlaProThrGlyThrAsn-186 214-TyrPheLysGlyAspAlaProLysValAla-223 246-XxxAsnLeuProArgAsnGluPhe-253 274-AlaGlnThrGlyAsnMetAspLysIle-282 311-LysTrpAsnAspSerValSerGlyArgThrLysThr-322 364-LeuTyrArgSerArgLysLysPheGlyAlaGlyLysThrTyrLysVal-379 Hydrophilic Regions - Hopp-Woods l-MetProThrLysThr-5 143-ArgLeuValAspArgPheThr-149 215-PheLysGlyAspAlaProLysValAla-223 248-LeuProArgAsnGluPhe-253 277-GlyAsnMetAspLys-281 316-ValSerGlyArgThrLysThr-322 366-ArgSerArgLysLysPheGlyAla-373 al05 AMPHI Regions - AMPHI H-TrpIleGlyLeuGly-15 22-ValThrArgLeuLeuAsp-27 51-LysValTyrGlyAsnThrAlaGluLeu-59 74-AlaAlaValCysAspIleLeuAsnGlyValArgAspGlyLeu-87 97-ThrIleSerProThr-101 110-ValGluAlaAlaGlyGlyGlnPheAlaGluAlaProVal-122 143-AlaValLeuAsnProLeuGlnLysIlePheSer-153 162-PheGlyAspValGlyLysGlySer-169 176-AsnSerLeuLeuGlyIlePheGlyGluAlaTyr-186 203-IleValGluAlaIleGlyGlySerAla-211 249-LeuGluGlnAlaGlyAsnThrLeuProAlaValGlu-260 263-AlaAlaSerTyrArgLysAlaValGluAla-272 Antigenic Index - Jameson-Wolf 2-SerAlaAsnGluTyrThr-7 25-LeuLeuAspGlyGlyIleGlu-31 34-ValTyrAsnArgSerProAspLysThrAlaProIleSerAlaLysGlyAlaLysValTyrGlyAsnThr-56 81-AsnGlyValArgAspGlyLeuAla-88 96-SerThrIleSerProThrGluAsnLeuAla-105 121-ProValSerGlySerValGlyProAlaThr-130 139-GlyGlySerGluAla-143 155-ValGlyLysLysThrPheHisPheGlyAspValGlyLysGlySerGly-170 196-PheGlyIleAspThrAspThrIleVal-204 210-SerAlaMetAspSerProMetPheGlnThrLysLysSerLeuTrpAlaAsnArgGluPheProPro-231 237-HisAlaSerLysAspLeuAsnLeuAlaValLysGluLeuGluGlnAlaGlyAsnThrLeuPro-257 264-AlaSerTyrArgLysAlaValGluAlaGlyTyrGlyGluGlnAspValSerGly-281 Hydrophilic Regions - Hopp-Woods 25-LeuLeuAspGlyGlyIle-30 37-ArgSerProAspLysThrAlaProIleSerAlaLysGlyAlaLys-51 81-AsnGlyValArgAspGlyLeuAla-88 164-AspValGlyLysGlySerGly-170 196-PheGlyIleAspThrAspThrIle-203 218-GlnThrLysLysSerLeuTrpAla-225 237-HisAlaSerLysAspLeuAsnLeuAlaValLysGluLeuGluGlnAlaGly-253 265-SerTyrArgLysAlaValGlu-271 273-GlyTyrGlyGluGlnAspVal-279 al09-2 AMPHI Regions - AMPHI 6-GlyThrTyrArgAspLeuHisArgProAlaSerGlu-17 53-LeuIleProAlaMetAlaGlyThrIleGly-62 69-AlaValAlaAlaAlaPhe-74 145-GlyLeuLeuMetAla-149 156-IleMetAlaLysLeuThrSer-162 177-GlyThrThrGlyGlnValLysLysLeuPheSerTrpAlaGly-190 207-ValMetTyrAlaLeuLeuGluHisTrpLysLysArgTrpLeu-220 222-ValProLeuGlyCys-226 294-HisGlnValPheGlnLysIle-300 326-ValGlySerIleLeuGly-331 336-ThrSerSerTrpGlyThr-341 471-AlaValGlyMetLeuProGlyIleProProPheLeuGluHisPheLysSerLeu-488 Antigenic Index - Jameson-Wolf l-MetGluLysHisAsnGlyThrTyrArgAspLeuHisArgProAlaSer-16 18-PheAlaThrArgAspGluTyrLeuGlu-26 32-MetGlnProLysArgTrpArgProAsnLeuProPheArgAspTyrArgPheGluTrp-50 78-LeuGlyLeuProAsp-82 109-ProGlyAlaAsnLeuProGlyThrHis-117 160-LeuThrSerAsnGlyVal-165 179-ThrGlyGlnValLysLys-184 245-AlaProGlyLeuProPro-250 259-GluAsnSerGlyTrp-263 301-SerTyrProGluLysThrAspLysVal-309 312-AsnIleAspAspThrMetThr-318 348-IleAlaLysArgProIleProGlyGly-356 398-AlaGlyMetGluMetThrArgLysGlyLysThrThrGlnSer-411 441-GlyCysLysGluArgSerAla-447 Hydrophilic Regions - Hopp-Woods l-MetGluLysHisAsnGlyThrTyrArgAspLeuHisArgProAlaSer-16 18-PheAlaThrArgAspGluTyrLeuGlu-26 35-LysArgTrpArgPro-39 44-ArgAspTyrArgPheGluTrp-50 180-GlyGlnValLysLys-184 301-SerTyrProGluLysThrAspLysVal-309 313-11eAspAspThrMetThr-318 348-IleAlaLysArgProIlePro-354 398-AlaGlyMetGluMetThrArgLysGlyLysThrThrGln-410 441-GlyCysLysGluArgSerAla-447 alll AMPHI Regions - AMPHI 6-ArgLeuProAsnPheIleArgThrLeu-14 58-ProSerProAlaGluIleGlnLysArgIleAspAspAlaLeuLysGluValAsnArgGlnMetSer-79 90-PheAsnGlnHisThrAlaGly-96 128-GlyProLeuValAsnLeuTrp-134 151-IleLysGlnAlaAlaSerTyrThrGly-159 170-AspTyrAlaSerLeu-174 183-LeuAspLeuSerSerIleAlaLys-190 209-TyrLeuValGluIleGlyGly-215 314-GluThrGluAlaLeu-318 Antigenic Index - Jameson-Wolf 1-MetProSerGluThrArgLeuProAsnPhe-lO 26-CysSerGluGlnThrAla-31 37-GlnGlyGluThrMetGly-42 49-TyrLeuSerAsnAsnArgAspLysLeuProSerProAlaGluIleGlnLysArgIleAspAspAlaLeuLysG luValAsnArgGlnMetSerThrTyrGlnProAspSerGluIleSerArgPheAsnGlnHisThrAlaGlyLysPr oLeuArgIleSerSerAspPhe-105 135-GlyPheGlyProAspLysSerValThrArgGluProSerProGluGlnIleLysGln-153 163-IleIleLeuLysGlnGlyLysAspTyrAlaSerLeuSerLysThrHisProLysAla-181 192-PheGlyValAspLysValAlaGlyGluLeuGluLysTyrGly-205 213-IleGlyGlyGluLeuHisGlyLysGlyLysAsnAlaArgGlyGluProTrpArgIleGlyIleGluGlnPro AsnIle-238 250-LeuAsnAsnArgSerLeuAlaThrSerGlyAspTyrArg-262 264-PheHisValAspLysSerGlyLysArgLeuSer-274 277-1leAsnProAsnAsnLysArgProl1eSer-286 299-AlaMetThrAlaAspGlyLeuSer-306 314-GluThrGluAlaLeuLysLeuAlaGluArgGluLysLeu-326 332-ValArgAspLysGlyGlyTyrArg-339 342-MetSerSerGluPheGluLysLeuLeuArg-351 Hydrophilic Regions - Hopp-Woods l-MetProSerGluThrArgLeu-7 26-CysSerGluGlnThrAla-31 51-SerAsnAsnArgAspLysLeuProSer-59 61-AlaGluIleGlnLysArgIleAspAspAlaLeuLysGluValAsnArgGln-77 82-GlnProAspSerGluIleSerArg-89 97-LysProLeuArgIleSerSer-103 137-GlyProAspLysSerValThrArgGluProSerProGluGlnIleLysGln-153 163-IleIleLeuLysGlnGlyLysAspTyrAlaSer-173 175-SerLysThrHisPro-179 192-PheGlyValAspLysValAlaGlyGluLeuGluLysTyrGly-205 217-LeuHisGlyLysGlyLysAsnAlaArgGlyGluProTrp-229 265-HisValAspLysSerGlyLysArgLeuSer-274 279-ProAsnAsnLysArgProIle-285 314-GluThrGluAlaLeuLysLeuAlaGluArgGluLysLeu-326 332-ValArgAspLysGlyGlyTyr-338 344-SerGluPheGluLysLeuLeuArg-351 all7-l AMPHI Regions - AMPHI 6-ProIleGlnAspThrGlnSerAla-13 15-LeuGlnGluLeuArgGluTrpPheAspSerTyrCysThr-27 57-GlyGluProLeuProAspHis-63 72-HisGluLeuAspLeuLeu-77 79-AspAlaValAlaAlaThrLeuLeuAlaAspIleGlyArgTyr-92 104-CysAsnSerThrValAlaGluLeuValLysGlyValAspGluValGlnLysLeuThrHisPheAlaArgVal AspSerLeu-130 145-LysMetLeuLeuAlaMet-150 170-PheLeuSerAsnAlaProAspSerProGluLys-180 216-GluProGluLysTyrArg-221 234-ArgLeuGluTyrIleGluAsnPheLeuAsnIleLeuArg-246 260-GlyArgProLysHisIleTyrSerIleTyrLys-270 282-LeuPheAspIleArg-286 290-IleLeuValAspThrValProGluCysTyrThrThrLeuGlyIleValHisSerLeuTrpGlnProIlePro GlyGluPheAspAspTyrIleAla-321 327-GlyTyrLysSerLeuHisThr-333 351-AspMetHisGlnPheAsnGluPheGlyValAla-361 385-GlnLeuLeuAspTrp-389 440-HisSerSerIleGlyAspArg-446 493-LysAlaIleGlyLysIleArgAlaTyr-501 504-GlnGlnAsnAlaAsp-508 521-GlnLeuAlaLysLeu-525 532-GlnGluLeuAlaGlu-536 539-GlyTyrLysLysProGluAspLeuTyrThr-548 557-AsnArgAlaIleGlnLysAlaCysGlyThrLeuAsnGluProPro-571 585-LysIleLysLysGlyGly-590 603-MetThrThrLeuAlaLysCysCysLysProAla-613 616-AspAspIleValGly-620 637-SerPheArgHisLeuAlaGluHisAlaProGluLysValLeuAspAla-652 679-ArgAspValSerAspAla-684 714-GlnValThrAspLeuProArgValLeuAlaSerLeuGlyAspValLysGlyValLeuSerValThrArg-73 6 Antigenic Index - Jameson-Wolf 5-SerProIleGlnAspThrGlnSerAlaThr-14 16-GlnGluLeuArgGluTrpPheAspSerTyrCysThrAlaLeuProAsnAsnAspLysLysLeu-36 52-AlaAlaThrProTyrGlyGluProLeuProAspHisPhe-64 88-AspIleGlyArgTyrValProAspTrp-96 100-ValSerGluArgCysAsnSerThrVal-108 110-GluLeuValLysGlyValAspGluValGlnLys-120 125-AlaArgValAspSerLeuAlaThrProGluGluArgAlaGlnGlnAlaGluThrMetArg-144 162-AlaMetArgThrArgThr-167 173-AsnAlaProAspSerProGluLysArgAlaValAlaLysGluThrLeu-188 209-AspLeuGlyPheArgHisGlnGluProGluLysTyrArgGlu-222 227-LeuAspGluLysArgThrGluArgLeuGluTyr-237 245-LeuArgThrGluLeuLysLys-251 258-ValAlaGlyArgProLysHis-264 271-LysMetValLysLysLysLeuSerPhe-279 294-ThrValProGluCysTyr-299 311-ProIleProGlyGluPheAspAspTyrIleAlaAsnProLysGlyAsnGlyTyrLysSer-330 335-IleValGlyProGluAspLysGlyValGluValGlnIleArgThr-349 364-TrpArgTyrLysGluGlyGlyLysGlyAspSerAlaTyrGluGlnLys-379 387-LeuAspTrpArgGluAsnMetAlaGluSerGlyLysGluAspLeuAlaAla-403 418-ThrProHisGlyLys-422 440-HisSerSerIleGlyAspArgCysArgGlyAlaLysValGluGly-454 461-ThrProLeuGluAsnGlyGlnArgValGluIleIleThrAlaLysGluGlyHisProSerValAsn-482 487-GlyTrpValLysSerAsnLysAlaIleGlyLys-497 502-IleArgGlnGlnAsnAlaAspThrValArgGluGluGlyArgValGlnLeuAspLysGlnLeuAla-523 525-LeuThrProLysProAsnLeuGlnGluLeuAlaGlu-536 538-LeuGlyTyrLysLysProGluAspLeu-546 551-GlyGlnGlyGluIleSerAsnArgAlaIleGlnLysAlaCysGlyThrLeuAsnGluProProProValPro -574 582-LysGlnSerLysIleLysLysGlyGlyLysAsnGlyVal-594 596-IleAspGlyGluAspGlyLeu-602 608-LysCysCysLysProAlaProProAspAspIleVal-619 622-ValThrArgAspArgGlyIleSerValHisArgLysThrCysProSerPhe-638 644-HisAlaProGluLysValLeuAsp-651 667-IleGluIleArgAlaGlnAspArgSerGlyLeuLeuArgAspValSerAspAlaLeuAlaArgHisLysLeu -690 696-GlnThrGlnSerArgAspLeuGluAlaSerMet-706 710-LeuGluValLysGlnValThrAspLeuProArg-720 726-GlyAspValLysGly-730 Hydrophilic Regions - Hopp-Woods 8-GlnAspThrGlnSer-12 16-GlnGluLeuArgGluTrpPhe-22 30-ProAsnAsnAspLysLysLeu-36 100-ValSerGluArgCysAsnSerThr-107 110-GluLeuValLysGlyValAspGluValGlnLys-120 125-AlaArgValAspSer-129 131-AlaThrProGluGluArgAlaGlnGlnAlaGluThrMetArg-144 162-AlaMetArgThrArgThr-167 174-AlaProAspSerProGluLysArgAlaValAlaLysGluThrLeu-188 209-AspLeuGlyPheArgHisGlnGluProGluLysTyrArgGlu-222 227-LeuAspGluLysArgThrGluArgLeuGluTyr-237 245-LeuArgThrGluLeuLysLys-251 258-ValAlaGlyArgProLysHis-264 271-LysMetValLysLysLysLeuSerPhe-279 314-GlyGluPheAspAsp-318 323-ProLysGlyAsnGly-327 337-GlyProGluAspLysGlyValGluValGlnIleArgThr-349 365-ArgTyrLysGluGlyGlyLysGlyAspSerAlaTyrGluGln-378 387-LeuAspTrpArgGluAsnMetAlaGluSerGlyLysGluAspLeuAlaAla-403 443-IleGlyAspArgCysArgGlyAlaLysValGluGly-454 463-LeuGluAsnGlyGlnArgValGluIleIleThrAlaLysGluGlyHisPro-479 489-ValLysSerAsnLysAlaIleGlyLys-497 505-GlnAsnAlaAspThrValArgGluGluGlyArgValGlnLeuAspLysGlnLeuAla-523 538-LeuGlyTyrLysLysProGluAspLeu-546 553-GlyGluIleSerAsn-557 582-LysGlnSerLysIleLysLysGlyGlyLys-591 596-IleAspGlyGluAspGlyLeu-602 608-LysCysCysLysProAlaProProAspAspIle-618 622-ValThrArgAspArgGlyIleSerValHisArgLysThrCysPro-636 644-HisAlaProGluLysValLeu-650 667-IleGluIleArgAlaGlnAspArgSerGlyLeuLeuArgAspValSerAspAlaLeuAlaArgHisLysLeu -690 697-ThrGlnSerArgAspLeuGluAlaSerMet-706 710-LeuGluValLysGlnValThrAspLeuProArg-720 726-GlyAspValLysGly-730 allθ AMPHI Regions - AMPHI 24-GlyLysTrpTyrAsp-28 57-IleProArgAspIle-61 65-IleGlyThrIleIleAspPheLeuMetValProAsn-76 94-11eHisGluArgTyrGluArgPheThrThrMetLeuArg-106 Antigenic Index - Jameson-Wolf 2-CysGluPheLysAspPheArgArgAsnIleProCys-13 15-GluGluTyrAspGluAsnSerPhe-22 24-GlyLysTrpTyrAspAspGlyValTrpAspAspGluGluTyrTrpLysLeuGluAsnAspLeuIleGluValA rgLysLysTyrProTyrProMetAspIleProArgAspIle-61 86-ProTrpLeuProAspSer-91 93-GlyIleHisGluArgTyrGluArg-100 109-PheThrGluLysAspIleVal-115 119-PheAspTyrTyrAsnLysLys-125 Hydrophilic Regions - Hopp-Woods 2-CysGluPheLysAspPheArgArgAsnIleProCys-13 15-GluGluTyrAspGlu-19 30-GlyValTrpAspAspGluGluTyrTrpLysLeuGluAsnAspLeuIleGluValArgLysLysTyrProTyr- 53 96-GluArgTyrGluArg-100 109-PheThrGluLysAspIleVal-115 121-TyrTyrAsnLysLys-125 al20 AMPHI Regions - AMPHI 6-LysAsnIlePheSerAla-ll 49-SerGlyAsnAlaTyrLysIleValSerThrIleLys-60 77-AsnThrLeuHisProThrTyrTyrArgAspI1eArgArg-89 142-IleThrAsnGlyLysLysLeuTyrSerValGlyGlyLeuAsnLysAlaGly-158 189-ProSerLeuAsnAsnIleProAla-196 Antigenic Index - Jameson-WoIf 35-SerGlySerTyrGly-39 45-ThrPheGluArgSerGlyAsnAlaTyrLys-54 68-PheGluSerGlyGlyThrValVal-75 85-ArgAspIleArgArgGlyLysLeuTyrAlaGlu-95 97-LysPheAlaAspGlySerValThrTyrGlyLysAlaGlyGluSerLysThrGluGlnSerProLysAla-119 131-AlaAsnAspAlaLysLeuProProGlyLeuLysIleThrAsnGlyLysLysLeuTyrSer-150 153-GlyLeuAsnLysAlaGlyThrGlyLysTyrSerIleGlyGlyValGluThrGluValValLysTyrArgVal ArgArgGlyAspAspAlaVa1-183 199-GlyTyrThrAspAspGlyLysThrTyr-207 218-GlyGlnAlaAlaLysPro-223 Hydrophilic Regions - Hopp-Woods 45-ThrPheGluArgSerGlyAsn-51 85-ArgAspIleArgArgGlyLysLeuTyrAla-94 107-LysAlaGlyGluSerLysThrGluGlnSerProLysAla-119 131-AlaAsnAspAlaLysLeu-136 143-ThrAsnGlyLysLysLeuTyr-149 155-AsnLysAlaGlyThrGly-160 167-ValGluThrGluValValLysTyrArgValArgArgGlyAspAspAla-182 200-TyrThrAspAspGlyLysThrTyr-207 219-GlnAlaAlaLysPro-223 al21-l AMPHI Regions - AMPHI 68-GlnGluLeuSerArgLeuTyrAlaGlnThr-77 101-ThrValArgHisAlaPro-106 148-ProAlaPheHisGlu-152 165-LeuAsnIleGlyGlyIleAlaAsnIle-173 189-ProGlyAsnMetLeuMetAspAlaTrpMetGlnAla-200 216-GlyAsnIleLeuProGlnLeuLeuAspArgLeuLeu-227 237-ProLysSerThrGly-241 251-GluThrTyrLeuAsp-255 262-AspValLeuArgThrLeuSerArgPheThrAlaGlnThrValPheAspAlaValSerHis-281 303-AlaAspLeuAlaGluCysPhe-309 341-ValAsnArgIleProGlySerPro-348 Antigenic Index - Jameson-Wolf 13-ThrSerMetAspGlyAlaAsp-19 23-IleArgMetAspGlyGlyLysTrpLeuGly-32 40-ProTyrProGlyArgLeuArgArgLysLeuLeuAspLeuGlnAspThrGlyAlaAspGluLeuHisArgSerA rgMetLeuSer-67 86-AsnLeuAlaProSerAspIleThrAla-94 97-CysHisGlyGlnThrValArgHisAlaProGluHisSerTyrSer-lll 119-LeuLeuAlaGluArgThrGln-125 129-ValGlyAspPheArgSerArgAspLeuAlaAlaGlyGlyGlnGly-143 154-LeuPheArgAspAspArgGluThrArgAla-163 177-ProProAspAlaPro-181 184-GlyPheAspThrGlyProGlyAsn-191 205-ProTyrAspLysAsnGlyAlaLysAlaAlaGlnGlyAsn-217 235-ProHisProLysSerThrGlyArgGlu-243 253-TyrLeuAspGlyGlyGluAsnArgTyrAspValLeuArgThrLeuSer-268 283-AlaAlaAspAlaArgGln-288 293-GlyGlyGlyIleArgAsnProValLeu-301 344-IleProGlySerProHisLysAlaThrGlyAlaSerLysProCysIle-359 Hydrophilic Regions - Hopp-Woods 13-ThrSerMetAspGlyAlaAsp-19 43-GlyArgLeuArgArgLysLeuLeuAspLeuGlnAspThrGlyAlaAspGluLeuHisArgSerArgMetLeuS er-67 101-ThrValArgHisAlaPro-106 119-LeuLeuAlaGluArgThrGln-125 131-AspPheArgSerArgAspLeuAlaAla-139 154-LeuPheArgAspAspArgGluThrArgAla-163 206-TyrAspLysAsnGlyAlaLysAlaAlaGln-215 236-HisProLysSerThrGlyArgGlu-243 254-LeuAspGlyGlyGluAsnArgTyrAspVal-263 283-AlaAlaAspAlaArgGln-288 344-IleProGlySerProHisLysAlaThrGlyAlaSer-355 al22-l AMPHI Regions - AMPHI 6-AsnIleHisLysThrPhe-ll 42-ThrPheLeuArgCysLeuAsnAlaLeuGluMetProGlu-54 102-LeuGluAsnValMetGlu-107 126-LysLeuLeuGluLys-130 176-ProGluLeuValGlnAspValLeuAsnAlaMetLysGluLeuAlaArgGluGly-193 227-ProLysGluLeuPheAspHisPro-234 Antigenic Index - Jameson-Wolf 5-ArgAsnIleHisLysThrPheGlyLysAsnThrIle-16 23-AspValCysLysGlyGln-28 34-GlyProSerGlySerGlyLysThrThr-42 51-GluMetProGluAspGlyGlnIleGluPheAspAsnGluArgProLeuLysIleAspPheSerLysLysProS erLysHisAspIle-79 81-AlaLeuArgArgLysSerGlyMet-88 96-PheProHisLysThrAlaLeu-102 114-GlyLysProAlaAlaGlnAlaArgGluGluAlaLeuLysLeuLeuGlu-129 131-ValGlyLeuGlyAspLysValAspLeu-139 145-SerGlyGlyGlnGlnGlnArgValGlyIle-154 168-AspGluProThrSerAlaLeuAspProGluLeuVal-179 184-AsnAlaMetLysGluLeuAlaArgGluGlyTrp-194 222-ValGluGlnGlySerProLysGluLeuPheAspHisProLysHisGluArgThrArgArgPheLeuSer-24 4 Hydrophilic Regions - Hopp-Woods 51-GluMetProGluAspGlyGlnIleGluPheAspAsnGluArgProLeuLysIleAspPheSerLysLysProS erLysHisAsp-78 81-AlaLeuArgArgLysSerGly-87 114-GlyLysProAlaAlaGlnAlaArgGluGluAlaLeuLysLeuLeuGlu-129 131-ValGlyLeuGlyAspLysValAsp-138 168-AspGluProThrSerAlaLeuAspProGluLeuVal-179 184-AsnAlaMetLysGluLeuAlaArg-191 224-GlnGlySerProLysGluLeuPheAspHisProLysHisGluArgThrArgArgPheLeu-243 al26-l AMPHI Regions - AMPHI 26-LeuLysGlnSerValArg-31 73-GlyCysGlnSerValGlnGluAla-80 112-PheGlnLeuValGluAla-117 143-LeuAspAlaGlyCysGln-148 150-LeuMetProTrpAlaAlaProIleGlyThrGlyLeuGlyAlaVal-164 213-SerGlyAspProValAsnMetAlaArgAlaPhe-223 Antigenic Index - Jameson-Wolf 7-GluThrPheProSerArgLeu-13 24-GluIleLeuLysGlnSerValArgThrAlaArg-34 41-SerLeuArgArgAlaGlyCysGlyGlyGluAlaHisGlyGlnGlyPhe-56 85-GlnMetAlaArgGluValPheGlu-92 99-GluLeuIleGlyAspAspAspThrLeuGln-108 121-LeuIleLysAspGlyPheLysValLeu-129 141-ArgLeuLeuAspAlaGlyCys-147 171-ValLeuArgGluArgLeuProAspThrProLeu-181 209-AlaValSerArgSerGlyAspProValAsn-218 228-GluSerGlyArgLeuAlaPhe-234 237-GlyProValGluAlaArgAspLysAlaGlnAlaSerThrProThrVal-252 Hydrophilic Regions - Hopp-Woods 24-GluIleLeuLysGlnSerValArgThrAlaArg-34 41-SerLeuArgArgAlaGlyCysGlyGlyGluAlaHis-52 85-GlnMetAlaArgGluValPheGlu-92 100-LeuIleGlyAspAspAspThrLeuGln-108 171-ValLeuArgGluArgLeuProAsp-178 210-ValSerArgSerGlyAspPro-216 228-GluSerGlyArgLeuAlaPhe-234 237-GlyProValGluAlaArgAspLysAlaGlnAla-247 al27 AMPHI Regions - AMPHI 6-MetLeuAspThrTrpLeuGlyAla-13 22-GluSerValAlaVal-26 119-ValGlyAspTyrIleGluIle-125 135-11eAsnLeuLeuAsnThrLeuMet-142 147-ProAsnProLeuValGlyGlnLeuAla-155 206-LeuGluProLeuCysAlaPro-212 214-IleProAlaIleGlnArgHisLeuGluAsnValGln-225 250-ArgIleIleValArgPheAlaSerProVal-259 268-AlaValMetAspGluPheLeuArgVal-276 Antigenic Index - Jameson-Wolf 16-IleArgAlaGluAlaValGlu-22 41-HisPheLysArgHisProAspPheGlyIleGluSerLysArgArgPheLeuVal-58 112-SerAlaThrGlnGlnTyrSerVal-119 126-AsnGlyLeuArgGlyArgValValAsp-134 169-HisProValArgArgAspAsnIleLeu-177 193-LeuAspSerAspGluAlaValCysArg-201 233-ProAlaAlaLysProArgValThrArgValProTyrAspAspLysAlaTyr-249 257-SerProValSerLysArgLeuGluIle-265 283-TyrProAlaGlySerGluThrLeu-290 Hydrophilic Regions - Hopp-Woods 16-IleArgAlaGluAlaValGlu-22 42-PheLysArgHisProAspPheGlyIleGluSerLysArgArgPheLeuVal-58 126-AsnGlyLeuArgGlyArgValVal-133 170-ProValArgArgAspAsnIleLeu-177 193-LeuAspSerAspGluAlaValCysArg-201 235-AlaLysProArgValThrArgValProTyrAspAspLysAlaTyr-249 259-ValSerLysArgLeuGluIle-265 285-AlaGlySerGluThrLeu-290 al28-l AMPHI Regions - AMPHI 43-AlaGlnThrHisThrGlyTrpAlaAsnThrValGluProLeuThrGlyIleThrGluArgValGlyArgIleT rpGlyValValSerHisLeuAsnSerValThrAspThrProGlu-81 85-AlaTyrAsnGluLeuMetProGluIle-93 102-GlnAspIleGluLeuTyrAsnArgPheLysThrIleLysAsnSerProGluPheAsp-120 166-PheSerGlnAsnValLeuAspAlaThrAsp-175 189-GlyIleProGluAspAla-194 2118-HisTyrLeuAlaVal-222 231-LeuArgGluGlnIleTyr-236 2 5-GluLeuSerAspAspGlyLysPheAspAsnThrAlaAsnIleAspArgThrLeuGluAsnAlaLeu-266 269-AlaLysLeuLeuGlyPheLysAsnTyrAlaGlu-279 286-MetAlaAspThrProGluGlnValLeuAsnPheLeuHisAspLeuAlaArgArgAla-304 313 -AlaGluValLysAlaPhe-318 359-GlyLysValLeuAsnGlyLeuPheAlaGlnIleLysLysLeuTyrGly-374 425-GlyArgArgArgPhe-429 472-LeuHisHisLeuLeuThrGlnValAspGluLeu-482 496-GluLeuProSerGlnPhe-501 565-GlyArgLeuLysAsnTrpGlnGlnValLeuAspSerVal-577 584-ValArgProProGluTyrAsnArgPheAlaAsnSerPheGlyHisIlePheAlaGlyGly-603 610-SerTyrAlaTrpAlaGlu-615 623-AlaAlaPheGluGluSerAspAsp-630 636-LysArgPheTrpGlnGluIleLeuAla-644 651-AlaAlaGluSerPheLysAlaPheArg-659 Antigenic Index - Jameson-Wolf 9-LeuGlyGluGluProArgPheAspGlnIleLysThrGluAspIleLysProAlaLeu-27 32-AlaGluAlaArgGluGlnIleAla-39 43 -AlaGlnThrHisThrGlyTrp-49 51-AsnThrValGluProLeuThr-57 59-IleThrGluArgValGlyArgIleTrp-67 75-SerValThrAspThrProGluLeuArgAlaAlaTyr-86 lOO-IleGlyGlnAspIleGluLeuTyrAsnArgPheLysThrIleLysAsnSerProGluPheAspThr-121 123-SerHisAlaGlnLysThrLysLeuAsnHisAspLeuArgAsp-136 140-SerGlyAlaGluLeuProProGluGlnGlnAlaGluLeuAlaLysLeuGlnThrGluGlyAlaGlnLeu-16 2 165-LysPheSerGlnAsnVal-170 172-AspAlaThrAspAla-176 190-IleProGluAspAla-194 202-AlaGlnSerGluGlyLysThrGlyTyrLys-211 226-AlaAspAsnArgLysLeuArgGluGlnlle-235 240-ValThrArgAlaSerGluLeuSerAspAspGlyLysPheAspAsnThrAlaAsnIleAspArgThrLeuGlu -263 285-LysMetAlaAspThrProGluGln-292 300-LeuAlaArgArgAlaLysProTyrAlaGluLysAspLeuAlaGlu-314 316-LysAlaPheAlaArgGluSerLeuGly-324 335-TyrAlaGlyGluLysLeuArgGluAlaLysTyrAlaPheSerGluThrGluValLysLys-354 376-GlyPheThrGluLysThrVal-382 387-LysAspValArgTyrPheGluLeuGlnGlnAsnGlyGluThrIle-401 409-TyrAlaArgGluGlyLysArgGlyGlyAla-418 420-Me AsnAspTyrLysGlyArgArgArgPheSerAspGlyThrLeu-434 446-ThrProProValGlyGlyLysGluAlaArgLeuSerHisAspGlu-460 478-GlnValAspGluLeuGlyVal-484 496-GluLeuProSerGln-500 516-SerAlaHisGluGluThrGlyVal-523 560-SerGluAspAspGluGlyArgLeuLysAsn-569 575-AspSerValArgLysGluValAlaValValArgProProGluTyrAsnArgPhe-592 605-SerAlaGlyTyrTyrSerTyr-611 625-PheGluGluSerAspAspValAlaAlaThrGlyLysArgPheTrp-639 646-GlyGlySerArgSerAlaAlaGluSerPheLysAlaPheArgGlyArgGluProSerIle-665 669-LeuArgHisSerGlyPheAspAsnAlaAla-678 Hydrophilic Regions - Hopp-Woods 9-LeuGlyGluGluProArgPheAspGlnIleLysThrGluAspIleLysPro-25 32-AlaGluAlaArgGluGlnlleAla-39 59-IleThrGluArgValGly-64 77-ThrAspThrProGluLeuArgAlaAlaTyr-86 lOO-IleGlyGlnAspIleGluLeu-106 lll-LysThrIleLysAsnSerProGluPheAspThr-121 123-SerHisAlaGlnLysThrLysLeuAsnHisAspLeuArgAsp-136 143-GluLeuProProGluGlnGlnAlaGluLeuAlaLysLeuGlnThrGluGlyAlaGlnLeu-162 190-IleProGluAspAla-194 202-AlaGlnSerGluGlyLysThrGlyTyr-210 226-AlaAspAsnArgLysLeuArgGluGlnlle-235 242-ArgAlaSerGluLeuSerAspAspGlyLysPheAspAsn-254 256-AlaAsnIleAspArgThrLeuGlu-263 285-LysMetAlaAspThrProGlu-291 300-LeuAlaArgArgAlaLysProTyrAlaGluLysAspLeuAlaGlu-314 316-LysAlaPheAlaArgGluSerLeuGly-324 335-TyrAlaGlyGluLysLeuArgGluAlaLysTyrAlaPheSerGluThrGluValLysLys-354 377-PheThrGluLysThr-381 387-LysAspVa1ArgTyr-391 396-GlnAsnGlyGluThr-400 409-TyrAlaArgGluGlyLysArgGlyGly-417 423-TyrLysGlyArgArgArgPheSerAsp-431 449-ValGlyGlyLysGluAlaArgLeuSerHisAspGlu-460 478-GlnValAspGluLeuGly-483 516-SerAlaHisGluGluThrGly-522 560-SerGluAspAspGluGlyArgLeuLysAsn-569 575-AspSerValArgLysGluValAlaVal-583 585-ArgProProGluTyrAsnArg-591 625-PheGluGluSerAspAspValAlaAlaThrGly-635 647-GlySerArgSerAlaAlaGluSerPheLysAlaPheArgGlyArgGluProSerIle-665 al30 AMPHI Regions - AMPHI 16-ThrLeuValSerGlyIle-21 36-GlySerGlySerPheGly-41 56-GlnProValGlyGlnLeu-61 91-AsnValProAsnAlaPro-96 llO-GlnGlyPheAspThrLeuPheGlnHisAlaLeuAsnGlyPheAsnAlaMet-126 171-ThrAlaSerAlaPro-175 204-PheGluAlaThrCysGln-209 211-CysHisGlyGlySerIleProGlyIlePro-220 234-LysGlyLysGluThr-238 245-GluGlyPheAsnAlaMet-250 Antigenic Index - Jameson-Wolf l-MetLysGlnLeuArgAspAsnLysAlaGlnGlySer-12 35-AlaGlySerGlySerPheGlyAspValAspAlaThrThrGluAlaAlaThrGlnThrArgIleGlnProValG ly-59 63-MetGlyAspGlyIleProValGlyGluArgGlnGlyGlu-75 87-AlaAlaAspSerAsnValProAsnAlaProLysLeuGluHisAsnGlyAspTrpAla-105 108-IleAlaGlnGlyPhe-112 126-MetProAlaLysGlyGlyAla-132 134-AspLeuThrAspGlnGluLeuLysArg-142 148-AlaAsnLysSerGlyGlySerPheProAsnProAspGluAlaAlaProAlaAspAsnAlaAlaSerGlyThr AlaSerAlaProAlaAspSerAlaAlaProAlaGluAlaLysAlaGluAspLysGlyAlaAla-192 197-GlyValAspGlyLysLysValPheGlu-205 221-GlyIleGlyLysLysAspAspTrpAlaProArgIleLysLysGlyLysGluThrLeuHis-240 251-ProAlaLysGlyGlyAsnAlaGlyLeuSerAspAspGluValLysAla-266 274-GlnSerGlyAlaLys-278 Hydrophilic Regions - Hopp-Woods 1-MetLysGlnLeuArgAspAsnLysAlaGlnGly-ll 41-GlyAspValAspAlaThrThrGluAlaAlaThr-51 68-ProValGlyGluArgGlnGlyGlu-75 87-AlaAlaAspSerAsnVal-92 96-ProLysLeuGluHisAsnGly-102 127-ProAlaLysGlyGlyAla-132 134-AspLeuThrAspGlnGluLeuLysArg-142 156-ProAsnProAspGluAlaAlaProAlaAspAsnAlaAla-168 174-AlaProAlaAspSerAlaAlaProAlaGluAlaLysAlaGluAspLysGlyAlaAla-192 198-ValAspGlyLysLysValPheGlu-205 222-IleGlyLysLysAspAspTrpAlaProArgIleLysLysGlyLysGluThrLeuHis-240 251-ProAlaLysGlyGlyAsn-256 258-GlyLeuSerAspAspGluValLysAla-266 al32-2 AMPHI Regions - AMPHI 13-IleIleSerAlaLeuAlaVal-19 70-AlaThrCysMetAlaMetVal-76 92-ValGlnGlnThrGlnGlnAlaProLysProValSerAsnThr-105 Antigenic Index - Jameson-Wolf 26-GlnHisGlyLysGlyAlaAspAla-33 38-GlySerGlySerGlySerAla-44 81-HisThrThrLysHisGlyLeuAspPhe-89 91-AsnValGlnGlnThrGlnGlnAlaProLysProValSerAsnThrGluProSerAlaProValProGlnGlnG lnLys-116 Hydrophilic Regions - Hopp-Woods 28-GlyLysGlyAlaAspAla-33 97-GlnAlaProLysProValSerAsnThrGluProSerAla-109 al34 AMPHI Regions - AMPHI 39-IleGlnSerAlaGlyThrVal-45 47-GlyLysLysThrGly-51 56-SerAspTrpMetAsplleGluLysGlnArg-65 83-ValAsnLeuLeuAspThrProGlyHis-91 97-AspThrTyrArgValLeuThrAlaVal-105 114-AlaAlaLysGlyValGlu-119 123-IleLysLeuLeuAsnValCysArg-130 142-LysTyrAspArgGluVal-147 149-AspSerLeuGluLeuLeuAspGluValGluAsnIleLeuGln-162 176-LysAsnPheLysGlyValTyrHisIleLeu-185 201-HisGluPheAspIleIleLysGlyIleAspAsn-211 254-PheGlySerAlaIle-258 265-GluIleLeuAsnSerLeuIleGluTrpAla-274 322-LysPheGluArgGlyMetLys-328 361-AspIleIleGlyIleProAsnHis-368 377-PheSerGluGlyGlu-381 395-LeuPheArgSerValArgIleLys-402 404-ProLeuLysIleLysGln-409 411-GlnLysGlyLeuGlnGlnLeuGlyGlu-419 423-ValGlnValPheLysProMetSer-430 449-SerArgLeuAlaAsnGluTyr-455 481-AlaGluPheGluLysAlaAsn-487 515-ArgTrpProAspIle-519 Antigenic Index - Jameson-Wolf 4-GluIleLeuAspGlnValArgArgArgArgThrPhe-15 19-SerHisProAspAlaGlyLysThrThrLeuThr-29 43-GlyThrValLysGlyLysLysThrGlyLysPheAlaThr-55 57-AspTrpMetAspIleGluLysGlnArgGly-66 76-PheAspTyrLysAspHisThrVal-83 85-LeuLeuAspThrProGlyHisGlnAspPheSerGluAspThrTyrArg-100 113-AspAlaAlaLysGlyValGlu-119 129-CysArgLeuArgAsnThrPro-135 140-MetAsnLysTyrAspArgGluValArgAspSerLeuGluLeuLeuAspGluValGluAsn-159 173-GlyMetGlyLysAsnPheLys-179 194-AlaGlyGlyGluArgLeuProHis-201 207-LysGlyIleAspAsnProGluLeuGluGlnArgPheProLeu-220 223-GlnGlnLeuArgAspGluIleGluLeu-231 235-AlaSerAsnGluPheAsnLeu-241 275-ProAlaProLysProArgAspAlaThrValArgMetValGluProAspGluProLysPhe-294 302-GlnAlaAsnMetAspProLysHisArgAspArgIleAla-314 317-ArgValCysSerGlyLysPheGluArgGlyMetLysMetLysHisLeuArgIleAsnArgGluIleAla-33 9 348-SerHisAspArgGluLeuValGlu-355 365-IleProAsnHisGly-369 373-IleGlyAspSerPheSerGluGlyGluGln-382 399-ValArgIleLysAsnProLeuLysIleLysGlnLeuGlnLysGlyLeuGlnGlnLeuGlyGluGluGlyAla -422 450-ArgLeuAlaAsnGluTyrGlyVal-457 473-SerCysAspAspLysLysLysLeuAlaGluPheGluLysAlaAsnAla-488 503-AlaProAsnArgValAsnLeu-509 511-LeuThrGlnGluArgTrpProAspIleVal-520 523-GluThrArgGluHisSerVal-529 Hydrophilic Regions - Hopp-Woods 4-GluIleLeuAspGlnValArgArgArgArgThr-14 21-ProAspAlaGlyLys-25 43-GlyThrValLysGlyLysLysThrGlyLys-52 59-MetAspIleGluLysGlnArgGly-66 77-AspTyrLysAspHisThr-82 92-GlnAspPheSerGluAspThrTyr-99 113-AspAlaAlaLysGlyValGlu-119 129-CysArgLeuArgAsn-133 142-LysTyrAspArgGluValArgAspSerLeuGluLeuLeuAspGluValGluAsn-159 194-AlaGlyGlyGluArgLeuProHis-201 207-LysGlyIleAspAsnProGluLeuGluGlnArgPheProLeu-220 223-GlnGlnLeuArgAspGluIleGluLeu-231 277-ProLysProArgAspAlaThrValArgMetValGluProAspGluProLysPhe-294 305-MetAspProLysHisArgAspArgIleAla-314 319-CysSerGlyLysPheGluArgGlyMetLysMetLysHisLeuArgIleAsnArgGluIleAla-339 348-SerHisAspArgGluLeuValGlu-355 376-SerPheSerGluGlyGluGln-382 399-ValArgIleLysAsnProLeuLysIleLysGlnLeuGlnLysGlyLeu-414 417-LeuGlyGluGluGlyAla-422 473-SerCysAspAspLysLysLysLeuAlaGluPheGluLysAlaAsnAla-488 512-ThrGlnGluArgTrpPro-517 523-GluThrArgGluHisSerVal-529 al35 AMPHI Regions - AMPHI 29-ThrIleThrArgGlnLeuAlaAlaLeu-37 85-GluTyrThrAlaAsnLeu-90 l69-AspIleAspGlyLeuTyrThr-175 185-ValArgLeuAspLysIleGluHis-192 212-GlyMetLeuThrLysIle-217 236-LeuLysProAspAla-240 242-AlaGluAlaAlaAspAsnGln-248 284-AlaGluHisAlaLeuSer-289 300-IleAlaGlyIleGluGly-305 308-SerArgMetAspThrValThrValTyr-316 318-LysAlaThrLysGlnPro-323 335-AlaAlaGluAspLeuLeuLysLeuArg-343 Antigenic Index - Jameson-Wolf l-MetLysTyrLysArgIleVal-7 H-GlyThrSerSerIleThrHisSerAspGlySerLeuSerArgGlyLysIle-27 60-GlyPheLysLysArgProValLysIleAlaAspLysGlnAlaSer-74 90-LeuSerSerAspGlylle-95 105-AlaAspPheAlaAspLysArgArgTyrGlnAsnAlaGlyGly-118 124-LeuGlnArgArgAlaVal-129 132-IleAsnGluAsnAspThrValSerValGluGluLeuLysIleGlyAspAsnAspThrLeu-151 176-GlyAsnProAsnSerAsnProAspAlaValArgLeuAspLysIleGluHisIleAsn-194 202-GlyGlySerGlySerAlaAsnGlyThrGly-211 215-ThrLysIleLysAla-219 224-ThrGluSerGlyVal-228 233-CysSerSerLeuLysProAspAlaLeuAlaGluAlaAlaAspAsnGlnAlaAspGly-251 257-ArgAlaLysGlyLeuArgThrGlnLysGln-266 271-TyrSerGluSerArgGlyGlyValTyrValAspGluGlyAlaGluHisAlaLeuSerGluGlnGlyLysSer LeuLeu-296 305-GlyHisPheSerArgMetAspThr-312 317-SerLysAlaThrLysGlnProLeuGlyLysGlyArgVal-329 335-AlaAlaGluAspLeuLeuLysLeuArgLysAlaLys-346 350-IleHisArgAspAspTrpIleSer-357 Hydrophilic Regions - Hopp-Woods l-MetLysTyrLysArgIleVal-7 16-ThrHisSerAspGlySerLeuSerArgGlyLysIle-27 60-GlyPheLysLysArgProValLysIleAlaAspLysGlnAlaSer-74 105-AlaAspPheAlaAspLysArgArgTyrGlnAsn-115 124-LeuGlnArgArgAlaVal-129 133-AsnGluAsnAspThrValSerValGluGluLeuLysIleGlyAspAsnAspThrLeu-151 178-ProAsnSerAsnProAspAlaValArgLeuAspLysIleGluHisIleAsn-194 215-ThrLysIleLysAla-219 236-LeuLysProAspAlaLeuAlaGluAlaAlaAspAsnGlnAlaAsp-250 257-ArgAlaLysGlyLeuArgThrGlnLys-265 272-SerGluSerArgGly-276 278-ValTyrValAspGluGlyAlaGluHisAlaLeuSerGluGlnGlyLys-293 306-HisPheSerArgMetAspThr-312 318-LysAlaThrLysGlnProLeuGlyLysGlyArgVal-329 335-AlaAlaGluAspLeuLeuLysLeuArgLysAlaLys-346 351-HisArgAspAspTrp-355 al36 AMPHI Regions - AMPHI 50-11eArgGlnCys11eArgGln-56 84-GlnCysHisAspGlyIleLysGlnLeuPheLysArgPheIleIleAspGlyPheLysProIleGlyArgHis- 107 119-CysValLysIleAla-123 148-ArgHisCysGlnAsn-152 170-GlnHisPheGlyGlnPro-175 177-GluArgCysGlnPheVal-182 194-AsnLeuValAlaThr-198 210-GlnPheAlaGlnPro-214 216-PheGlyCysPheGlyLysPheSerGlyIleHisHisPhe-228 247-LysAlaThrLysProGlnThrValGlnIleValArg-258 Antigenic Index - Jameson-Wolf l-MetGluThrAsnAla-5 34-AlaAspGlyLeuArgLeuValAspAspArgLeuProVal-46 48-ValAspIleArgGlnCysIle-54 69-LeuGlnThrAspSer-73 84-GlnCysHisAspGlyIleLysGlnLeuPhe-93 99-AspGlyPheLysProIleGlyArgHisAsnIle-109 139-IleArgHisArgGlyGlyCysPheHisArgHisCysGlnAsnGlnProPheAsp-156 159-ThrPheGlyGlyGlyLysLeuArg-166 171-HisPheGlyGlnProValGluArg-178 184-ProAlaGlnGlnArgArgHisLysThr-192 214-ProProPheGlyCysPheGlyLysPheSerGly-224 242-AsnLeuAsnGlnAspLysAlaThrLysProGln-252 257-ValArgGlnGlyGluAlaThrProTyr-265 270-AsnProLeuTyrArgArgAsnAlaVal-278 Hydrophilic Regions - Hopp-Woods 35-AspGlyLeuArgLeuValAspAspArgLeuProVal-46 48-ValAspIleArgGlnCysIle-54 87-AspGlyIleLysGlnLeuPhe-93 185-AlaGlnGlnArgArgHisLysThr-192 244-AsnGlnAspLysAlaThrLysProGln-252 273-TyrArgArgAsnAlaVal-278 al37 AMPHI Regions - AMPHI 24-LeuSerTyrIleLeuGlyPhe-30 49-ThrLysGluSerLeu-53 55-AspPheLeuThrTrpGly-60 78-PheSerAspTyrLeuAlaHisProLeuAspIlePheLysValTrpGluGlyGly-95 101-GlyPheLeuGlyValValIle-107 120-PheLeuLysLeuMetAspThrValAlaProLeuValPro-132 139-ArgIleGlyAsnPheIle-144 149-TrpGlyArgValThrAspIleAsnAlaPhe-158 178-ProLeuTrpAlaGluTrpLeuGlnGlnTyr-187 190-LeuProArgHisProSerGlnLeu-197 232-TyrGlyIlePheArgPheIleAlaGluPheAlaArgGlnProAspAspTyrLeuGly-250 Antigenic Index - Jameson-Wolf 36-LeuGlyArgArgArgIleAlaGln-43 48-PheThrLysGluSerLeuAspAsp-55 92-TrpGluGlyGlyMet-96 113-GlyArgLysHisGlyIle-118 136-AlaSerGlyArgIle-140 164-ProGlnAlaArgTyrGluAspLeuGluAla-173 191-ProArgHisProSerGlnLeu-197 214-PheSerLysLysGlnArgProThrGly-222 241-PheAlaArgGlnProAspAspTyrLeu-249 277-PheGlyMetLysLysGlnHis-283 Hydrophilic Regions - Hopp-Woods 37-GlyArgArgArgIleAla-42 48-PheThrLysGluSerLeuAsp-54 166-AlaArgTyrGluAspLeuGluAla-173 216-LysLysGlnArgProThrGly-222 241-PheAlaArgGlnProAspAspTyr-248 278-GlyMetLysLysGlnHis-283 al38 AMPHI Regions - AMPHI 21-ProTyrIleArgArgPheSerGlySer-29 74-AsnAlaMetLeuGluLysVal-80 85-GluPheValGlnGlyMet-90 109-ValAsnLysGluIleValSerMetIleAsnThrTyrGly-121 152-IleGlyGlnValGlyThrValGluSerIle-161 163-ThrGlyLeuValLysGlyLeu-169 199-GlyLysLeuAlaGluGluLeu-205 213-MetThrAsnIleAlaGlyValMetAspLysThrGlyAsnLeuLeuThrLysLeuThr-231 234-ArgIleAspGluLeuIle-239 247-GlyMetLeuProLysIleAlaSerAlaValGluAlaAlaValAsn-261 276-AlaLeuLeuLeuGluIlePheThrAspAla-285 Antigenic Index - Jameson-Wolf l-MetGluSerGluAsnIle-6 9-AlaAlaAspLysAlaArgIleLeu-16 23-IleArgArgPheSerGlySer-29 35-TyrGlyGlyAsnAlaMetThr-41 43-ProAlaLeuLysGluGlyPheAla-50 68-GlyGlyGlyProGln-72 76-MetLeuGluLysValGlyLysLysGlyGluPhe-86 91-ArgValThrAspLysGluAlaMetAsp-99 109-ValAsnLysGluIle-113 128-SerGlyArgAspAspHisPheIleLysAlaLysLysLeuLeuIleAspThrProGluGlnAsnGlyValAsp IleGlyGln-154 159-GluSerIleAspThrGlyLeu-165 169-LeuIleGluArgGlyCysIle-175 182-GlyValGlyGluLysGlyGluAla-189 200-LysLeuAlaGluGluLeuAsnAlaGluLys-209 219-ValMetAspLysThrGlyAsnLeuLeuThrLysLeuThrProLysArgIleAspGluLeuIleAla-240 259-AlaValAsnGlyValLys-264 269-IleAspGlyArgValProAsnAla-276 292-LeuGlyGlyGlyGluAspAla-298 Hydrophilic Regions - Hopp-Woods 1-MetGluSerGluAsn-5 9-AlaAlaAspLysAlaArgIleLeu-16 43-ProAlaLeuLysGluGlyPheAla-50 76-MetLeuGluLysValGlyLysLysGlyGluPhe-86 91-ArgValThrAspLysGluAlaMetAsp-99 109-ValAsnLysGluIle-113 128-SerGlyArgAspAspHisPheIleLysAlaLysLysLeuLeuIleAspThrProGluGlnAsnGlyValAsp -151 183-ValGlyGluLysGlyGluAla-189 200-LysLeuAlaGluGluLeuAsnAlaGluLys-209 219-ValMetAspLysThrGly-224 230-LeuThrProLysArgIleAspGluLeuIleAla-240 269-IleAspGlyArgVal-273 294-GlyGlyGluAspAla-298 al40 AMPHI Regions - AMPHI 10-TyrLeuAsnArgThr-14 26-IleGlyArgAspTyrSerPhePhe-33 45-SerLeuAspSerValGluLysThrAlaGly-54 68-AsnAlaAlaArgThrAlaSer-74 108-SerAlaThrProGluThrValGluThrAlaAla-118 135-ArgAlaAlaAlaAlaValGlnHisAlaAsnAlaAlaAspGlyValArgIlePheAsnAsnLeuAlaAlaThr Val-159 175-LeuLysAlaValSerAspGlyLeuAsp-183 189-LeuArgValIleAlaGln-194 254-SerLeuPheAlaGly-258 266-IleGlyTyrLeuLysGlyLeuPheSerTyr-275 290-GluHisAlaGluGlySer-295 303-LeuGlyAlaLeuGly-307 352-GlyThrLeuValGlyLeu-357 391-GlyGlyPheThrGlyAlaThr-397 412-ArgLeuValAlaGlyLeu-417 425-AsnGlyTrpAsnGlyLeuAlaArg-432 Antigenic Index - Jameson-Wolf 2-SerAlaGlyGlyLysGlyAlaGlyTyrLeuAsnArgThrGlyGlnArgValPro-19 25-LysIleGlyArgAspTyrSer-31 35-AsnIleGluThrAspGlyGlyLeu-42 47-AspSerValGluLysThrAlaGlySerGluGlyAspThrLeu-60 63-TyrValArgArgGlyAsnAlaAlaArgThrAlaSer-74 86-HisAlaValGluGlnGlyGlySerAsnLeuGlu-96 102-LeuAspAlaSerGluSerSerAlaThrProGluThrValGlu-115 117-AlaAlaAlaAspArgThrAspMetProGlyIleArgProTyrGly-131 144-AsnAlaAlaAspGly-148 160-TyrAlaAspSerThrAlaAla-166 169-AspMetGlnGlyArgArgLeuLysAlaValSerAspGlyLeuAspHisAsnAlaThrGly-188 195-ThrGlnGlnAspGlyGlyThrTrpGluGlnGlyGlyValGluGlyLysMetArgGlySerThrGln-216 221-AlaAlaLysThrGlyGluAsnThrThr-229 240-ThrTrpSerGluAsnSerAlaAsnAlaLysThrAspSer-252 259-IleArgHisAspAlaGlyAsp-265 274-SerTyrGlyArgTyrLysAsnSerIleSerArgSerThrGlyAlaAspGluHisAlaGluGlySerValAsn -297 315-AlaThrGlyAspLeuThrValGluGlyGlyLeuArg-326 333-AspAlaPheAlaGluLysGlySerAlaLeuGlyTrpSerGlyAsnSerIleThrGluGlyThr-353 362-LeuSerGlnProLeuSerAspLysAla-370 377-GlyValGluArgAspLeuAsnGlyArgAspTyrThrVal-389 399-AlaThrGlyLysThrGlyAlaArgAsnMetProHisThr-411 421-ValGluPheGlyAsnGlyTrp-427 434-SerTyrAlaGlySerLysGlnTyrGlyAsnHisSerGlyArgValGlyVal-450 Hydrophilic Regions - Hopp-Woods 3-AlaGlyGlyLysGly-7 36-IleGluThrAspGly-40 47-AspSerValGluLysThrAlaGlySerGluGlyAspThr-59 64-ValArgArgGlyAsnAlaAlaArgThrAlaSer-74 86-HisAlaValGluGlnGlyGlySerAsnLeu-95 102-LeuAspAlaSerGluSerSerAlaThrProGluThrValGlu-115 117-AlaAlaAlaAspArgThrAspMetProGly-126 144-AsnAlaAlaAspGly-148 169-AspMetGlnGlyArgArgLeuLysAlaValSerAspGlyLeuAspHisAsnAlaThr-187 205-GlyGlyValGluGlyLysMetArgGlySerThr-215 223-LysThrGlyGluAsnThrThr-229 244-AsnSerAlaAsnAlaLysThrAspSer-252 259-IleArgHisAspAlaGlyAsp-265 277-ArgTyrLysAsnSerIleSerArgSerThrGlyAlaAspGluHisAlaGluGlySerVal-296 333-AspAlaPheAlaGluLysGlySer-340 364-GlnProLeuSerAspLysAla-370 377-GlyValGluArgAspLeuAsnGlyArgAspTyrThr-388 399-AlaThrGlyLysThrGlyAlaArgAsnMetPro-409 al41 AMPHI Regions - AMPHI ll-GlnSerSerThrMetArgProIleGlyGluIle-21 32-IleGluProTyrGly-36 44-ProAlaGluAlaPheLysLeuPro-51 80-AlaAspAlaLeuArgHisIle-86 131-PheHisAlaIleGlyAla-136 139-AsnLeuLeuAlaAlaMetLeuAspAsn-147 174-GlnLeuArgAsnIleIleAspGlyMetGlyLysProValAspGlyValMetArgPro-192 212-AsplleSerAspLeuLysGluArgLeuGly-221 245-MetAlaAlaLeuLeuLysAspAlaIleLysProAsnLeu-257 259-GlnThrIleGluGlyThrPro-265 272-ProPheAlaAsnIleAlaHisGlyCysAsnSerValThrAlaThrArgLeuAlaLysHisLeuAlaAspTyr Ala-296 330-AlaThrValArgAla-334 351-LeuAspAlaLeuGluLysGlyLeuProAsnLeuLeuLysHisIleSerAsnLeuLysAsnValPheGly-37 3 406-SerLeuThrGluValTrpGlyLys-413 420-AspLeuAlaArgLysValValAsnAlaIleGluSerGln-432 473-IleAlaSerLeuGluLys-478 525-ValAlaLeuCysGlyAsnMetMetLysMetProGlyLeuProLysValProAlaAla-543 Antigenic Index - Jameson-Wolf 3-PheLysThrAspAlaGluIleAlaGlnSerSerThrMetArgProIleGly-19 27-LeuAsnValAspAsnIleGluProTyrGly-36 38-TyrLysAlaLysIleAsnProAlaGluAlaPheLysLeuProGlnLysGlnGlyArg-56 64-AsnProThrProAlaGlyGluGlyLysThrThr-74 81-AspAlaLeuArgHisIleGlyLysAspSerValIleAlaLeuArgGluProSerLeuGlyPro-101 105-ValLysGlyGlyAlaAlaGlyGlyGly-113 151-GlnGlyAsnGluLeuAsnIleAspProLysArgValLeuTrp-164 166-ArgValValAspMetAsnAspArgGlnLeuArgAsnIleIleAspGlyMetGlyLysProValAspGlyVal MetArgProAspGlyPheAspIle-197 211-LysAspIleSerAspLeuLysGluArgLeuGly-221 227-TyrAlaLysAspGlySerProValTyr-235 237-LysAspLeuLysAlaAsnGly-243 251-AspAlaIleLysProAsnLeu-257 287-ArgLeuAlaLysHisLeuAla-293 306-LeuGlyAlaGluLysPheCysAspIleLysCysArgLeuAlaGlyLeuLysProAspAla-325 335-LeuLysTyrAsnGlyGlyValGluArgAlaAsnLeuGlyGluGluAsnLeuAspAlaLeuGluLysGlyLeu ProAsnLeu-361 383 -PheValSerAspSerAspAlaGluLeuAlaMetIleGluLysAlaCysAla-399 411-TrpGlyLysGlyGlyAlaGlyGlyAlaAspLeuAlaArgLysValValAsn-427 429-IleGluSerGlnThrAsnAsnPheGly-437 444-LeuGlyIleLysAspLysIleArgAlaIleAla-454 458-TyrGlyAlaGluAspValAspPheSerAla-467 474-AlaSerLeuGluLysLeuGlyLeuAspLysMetPro-485 494-SerLeuSerAspAsnAlaLysLeu-501 503-GlyCysProGluAspPheArgIle-510 534-MetProGlyLeuPro-538 541-ProAlaAlaGluLysIleAspValAspAlaGluGly-552 Hydrophilic Regions - Hopp-Woods 3-PheLysThrAspAlaGluIleAlaGln-ll 38-TyrLysAlaLysIleAsnPro-44 46-GluAlaPheLysLeuProGlnLysGlnGlyArg-56 67-ProAlaGlyGluGlyLysThr-73 81-AspAlaLeuArgHisIleGlyLysAspSerValIleAlaLeuArgGluProSer-98 155-LeuAsnIleAspProLysArgValLeuTrp-164 166-ArgValValAspMetAsnAspArgGlnLeuArgAsnIleIle-179 181-GlyMetGlyLysProValAspGlyValMetArgProAspGlyPhe-195 211-LysAspIleSerAspLeuLysGluArgLeuGly-221 228-AlaLysAspGlySer-232 237-LysAspLeuLysAla-241 287-ArgLeuAlaLysHisLeuAla-293 306-LeuGlyAlaGluLysPheCysAspIleLysCysArgLeuAlaGlyLeuLysProAspAla-325 339-GlyGlyValGluArgAlaAsnLeuGlyGluGluAsnLeuAspAlaLeuGluLysGlyLeu-358 383-PheValSerAspSerAspAlaGluLeuAlaMetIleGluLysAlaCysAla-399 420-AspLeuAlaArgLysValValAsn-427 444-LeuGlyIleLysAspLysIleArgAlaIleAla-454 458-TyrGlyAlaGluAspValAspPheSerAla-467 474-AlaSerLeuGluLysLeuGlyLeuAspLysMetPro-485 503-GlyCysProGluAspPheArgIle-510 541-ProAlaAlaGluLysIleAspValAspAlaGluGly-552 al42 AMPHI Regions - AMPHI 26-ArgPheAlaAlaMetProAspValValGlyLys-36 44-GlyGlnProGlyLysMetPhe-50 100-AlaValThrProCysArg-105 107-ValCysArgAspAspMetAsn-113 118-GlyCysHisArgIleThrGluArgSerLeuLysSerPheLeuGlnIleArgHisPheSerProLeu-139 174-LeuArgValGlnArgIleLeuAspPheGlyLysPheCysGlnGlnVal-189 202-LeuAspSerValValThrLeuValHisPhePheAlaAspPheLeuIle-217 239-AlaAspAsnGlnThrArgPhePheLysAlaGly-249 259-AsnAlaArgLeuIleArgGlnIleLeuLys-268 Antigenic Index - Jameson-Wolf 31-ProAspValValGly-35 38-LeuPheGlyArgGlnAlaGlyGlnProGlyLysMet-49 59-GlnArglleAspAlaGluAlaAlaValPheArgGlnAspArgAsnAspSerArgThrProValAspAlaGlnH isHisGlyArgArgLeuValArgAsnArgArgAsnArgArgHisCysAsnAla-100 102-ThrProCysArgThrValCysArgAspAspMetAsnAlaCysArgThrGlyCysHisArgIleThrGluArg SerLeuLys-128 147-AlaAlaHisLysAla-151 153-ProMetCysSerSerSerAspSerLysSerArgArgSerAspIleSerAlaArgTyr-171 180-LeuAspPheGlyLysPheCys-186 225-GlnLeuGlnLysAsnThrSer-231 237-PheGlnAlaAspAsnGlnThrArgPhePheLysAlaGlyGlnAspThrGlyGlnAlaGlyAlaGlnAsn-25 9 267-LeuLysValGlnArgAlaValPheArgGlnLysThrAspAsnProPro-282 291-IleGlnAsnArgProGluLeuGlyHisGlnGly-301 307-GlnThrAspIleAspArgArgMetPhe-315 Hydrophilic Regions - Hopp-Woods 42-GlnAlaGlyGlnPro-46 59-GlnArgIleAspAlaGluAlaAlaValPheArgGlnAspArgAsnAspSerArgThrProValAspAlaGlnH isHisGlyArgArgLeuValArgAsnArgArgAsnArgArgHisCys-98 106-ThrValCysArgAspAspMetAsnAlaCysArg-116 121-ArgIleThrGluArgSerLeuLys-128 147-AlaAlaHisLysAla-151 156-SerSerSerAspSerLysSerArgArgSerAspIleSerAla-169 237-PheGlnAlaAspAsnGlnThrArgPhePheLysAlaGlyGlnAspThrGlyGln-254 267-LeuLysValGlnArgAlaValPheArgGlnLysThrAspAsn-280 291-IleGlnAsnArgProGluLeuGly-298 309-AspIleAspArgArgMetPhe-315 al44 AMPHI Regions - AMPHI 36-LeuGlyGlyIleValGlnGluPhe-43 45-ValLeuAlaAspGlyValArg-51 71-IleAsnLysGlnIleGlyArgValAlaGlyArg-81 136-ValGlyArgArgLeu-140 159-TyrArgTyrLeuSerArgHis-165 185-GlyProAlaArgCysGlySerAlaTyrSerAlaGly-196 200-SerGlyArgCysArgLysThrAlaArgLeuAsnGlyPheArgArgProArgSer-217 Antigenic Index - Jameson-Wolf l-MetSerAspThrProAlaThrArgAspPheGlyLeuIleAspGlyArgAla-17 23-LeuSerAsnArgArgGlyThrArg-30 48-AspGlyValArgGlu-52 58-PheAspAspAlaAlaSerTyrAlaAspAsnProPheGlnIleAsn-72 78-ValAlaGlyArgIleArgGlyAlaAla-86 88-AspIleAsnGlyArgThrTyrArgValGluAlaAsnGluGlyArgAsnAlaLeuHisGlyGlySerHis-110 121-AlaAlaAspGlyArgSerValValLeu-129 135-ThrValGlyArgArgLeuSerGlnArgPheGly-145 151-ProLeuGlyArgGlyArgProAlaTyr-159 161-TyrLeuSerArgHisArgAlaArgArgHisGlyValArgProAspAlaAlaHis-178 182-AlaGlyArgGlyProAlaArgCysGlySer-191 194-SerAlaGlyArgThrTyrSerGlyArgCysArgLysThrAlaArgLeuAsnGlyPheArgArgProArgSer Ile-218 Hydrophilic Regions - Hopp-Woods l-MetSerAspThrProAlaThrArgAsp-9 24-SerAsnArgArgGlyThrArg-30 48-AspGlyValArgGlu-52 58-PheAspAspAlaAlaSer-63 78-ValAlaGlyArgIleArgGlyAlaAla-86 89-IleAsnGlyArgThrTyrArgValGluAlaAsnGluGlyArgAsnAlaLeu-105 121-AlaAlaAspGlyArgSerValValLeu-129 135-ThrValGlyArgArgLeuSerGln-142 153-GlyArgGlyArgProAla-158 163-SerArgHisArgAlaArgArgHisGlyValArgProAspAla-176 183-GlyArgGlyProAlaArgCys-189 197-ArgThrTyrSerGlyArgCysArgLysThrAlaArg-208 210-AsnGlyPheArgArgProArgSerIle-218 al46 AMPHI Regions - AMPHI 19-GluGlnTyrGlyLeuPheAspPheMetProCys-29 34-ProLeuAspAsnPheProThrVal-41 64-GlyPheGlyGlnArgl1eSerAsnLeuSerArg-74 95-LeuArgAlaCysAla-99 105-HisValArgValPheGlnLys-lll 140-ThrArgArgValArg-144 158-ArgHisGlnArgGlyPheAlaArg-165 Antigenic Index - Jameson-WoIf 6-LeuArgProArgGlnValIleIleAspHisAspLysIleGluGln-20 29-CysLeuArgGlnProProLeuAspAsn-37 41-ValArgProAlaSerValGluThrArgSerLysHisIleGluArgArgArgGlnAspLysAspAlaAspGlyP heGlyGlnArgIleSerAsnLeuSer-73 86-ThrCysArgArgGlnArgIleHisThr-94 112-SerLeuLeuArgAspLysArgLeuLys-120 138-ArgArgThrArgArgValArgHisGlyAsnAlaGln-149 155-GlnGlnProArgHisGlnArgGlyPheAla-164 166-AlaGlySerGlyArgAsnAspLysAspValAlaPheSerIle-179 195-GlnArgThrProGlyPhe-200 Hydrophilic Regions - Hopp-Woods 6-LeuArgProArgGlnValIleIleAspHisAspLysIleGluGln-20 44-AlaSerValGluThrArgSerLysHisIleGluArgArgArgGlnAspLysAspAlaAspGlyPheGly-66 86-ThrCysArgArgGlnArglleHisThr-94 112-SerLeuLeuArgAspLysArgLeuLys-120 138-ArgArgThrArgArgValArgHisGlyAsn-147 156-GlnProArgHisGlnArgGlyPheAla-164 167-GlySerGlyArgAsnAspLysAspValAla-176 al48 AMPHI Regions - AMPHI 25-AlaAspLysIleArgLysIleGluAsnTrpPro-35 49-GlnSerAlaGluTyrPheArgLeuLeuValAspLeu-60 150-AlaGlyLeuGluLeuIleArgLysLeuGlyGlyGluIle-162 165-AlaAlaAlaIleLeuGluPheThrAspLeuGlnGlyGlyLysAsnIleArg-181 Antigenic Index - Jameson-Wolf 4-LysThrSerAsnLeu-8 24-LeuAlaAspLysIleArgLysIleGluAsnTrpProGlnLysGly-38 66-MetAspGlnLysIleAspIle-72 76-LeuAspAlaArgGly-80 97-ProIleArgLysLysGlyLysLeuPro-105 117-TyrGlyGluAlaAlaVal-122 124-IleHisThrAspAlaValLysLeuGlySer-133 153-GluLeuIleArgLysLeuGlyGlyGluIleValGlu-164 172-ThrAspLeuGlnGlyGlyLysAsnIleArgAlaSerGlyAlaPro-186 192-GlnAsnGluGlyCysMetLysGly-199 Hydrophilic Regions - Hopp-Woods 24-LeuAlaAspLysIleArgLysIleGluAsnTrpPro-35 66-MetAspGlnLysIleAspIle-72 97-ProIleArgLysLysGlyLysLeuPro-105 117-TyrGlyGluAlaAlaVal-122 124-IleHisThrAspAlaValLysLeuGlySer-133 153-GluLeuIleArgLysLeuGlyGlyGluIleValGlu-164 178-LysAsnIleArgAlaSerGly-184 195-GlyCysMetLysGly-199 al49 AMPHI Regions - AMPHI 72-AsnLeuGlyAspAlaLeuAspGlyValProGlyIle-83 101-ThrGlyArgArgIleLysValLeuAsnHisHisGlyGluThrGlyAspMet-117 135-GlnValGluIleLeuArgGlyProValThr-144 152-ValAlaGlyLeuValAsp-157 164-ProGluLysMetProGluAsnGlyVal-172 184-AsnLeuGluLysLeu-188 220-TyrArgAsnLeuLysArgLeuProAspSerHis-230 345-PheProGlyPheGlu-349 366-AlaGlyAspAlaValGluAsnPhePheAsnAsn-376 389-ProIleGlyArgLeuLys-394 411-AlaThrSerGluAla-415 565-ArgPheGlyAsnTyrIleTyrAlaGln-573 576-AsnAspGlyArgGlyProLysSerIleGluAsp-586 627-ArgGlyArgLeuLysAsnLeuProSer-635 Antigenic Index - Jameson-Wolf 23-GlnAlaHisGlyThrGluGlnSerVal-31 40-GlyLysSerArgProArgAlaThrSerGly-49 55-ThrAlaSerAspLysIleIleSerGlyAspThrLeuArgGlnLysAla-70 97-IleArgGlyGlnThrGlyArgArgIleLysVal-107 109-AsnHisHisGlyGluThrGlyAspMetAlaAspPheSerProAspHis-124 137-GluIleLeuArgGlyPro-142 157-AspValAlaAspGlyLysIleProGluLysMetProGluAsnGlyValSerGlyGluLeuGlyLeu-178 180-LeuSerSerGlyAsnLeuGluLysLeuThrSerGlyGly-192 207-GlyLeuTyrArgLysSerGlyAspTyrAlaValProArgTyrArgAsnLeuLysArgLeuProAspSerHis AlaAspSerGlnThrGly-236 244-GlyGluLysGlyPhe-248 252-AlaTyrSerAspArgArgAspGlnTyrGly-261 263-ProAlaHisSerHisGluTyrAspAspCysHisAla-274 281-SerLeuIleAsnLysArgTyrLeu-288 295-LeuThrGluGluAspIleAspTyrAspAsnProGlyLeu-307 310-GlyPheHisAspAspAspAspAlaHis-318 321-AlaHisAsnGlyLysProTrpIleAspLeuArgAsnLysArgTyrGluLeuArgAlaGluTrpLysGlnPro PheProGly-347 354-HisLeuAsnArgAsnAspTyrArgHisAspGluLysAlaGlyAspAlaVal-370 374-PheAsnAsnGlnThrGlnAsnAlaArgIleGluLeuArgHisGlnProIleGlyArgLeuLysGlySerTrp -397 402-LeuGlyGlnLysSerSerAlaLeu-409 411-AlaThrSerGluAlaValLys-417 422-LeuAspAsnLysVal-426 437-AlaAsnTrpAspAsnPheThrLeuGluGlyGlyValArgValGluLysGlnLysAlaSerIleArgTyrAsp LysAlaLeuIleAspArgGluAsnTyrTyrAsnHisProLeuProAsp-476 478-GlyAlaHisArgGlnThrAla-484 506-SerHisGlnGluArgLeuProSerThrGlnGluLeuTyrAlaHisGly-521 531-ValGlyAsnLysHisLeuAsnLysGluArgSerAsnAsnIle-544 550-TyrGluGlyAspArgTrpGln-556 562-TyrArgAsnArgPheGlyAsn-568 574-ThrLeuAsnAspGlyArgGlyProLysSerIleGluAspAspSerGluMetLysLeu-592 594-ArgTyrAsnGlnSerGlyAlaAspPheTyrGlyAlaGluGly-607 609-1leTyrPheLysProThrProArgTyrArglle-619 621-ValSerGlyAspTyrValArgGlyArgLeuLysAsnLeuProSerLeuProGlyArgGluAspAlaTyrGly AsnArg-646 651-GlnAlaAspGlnAsnAlaProArgValProAla-661 671-SerLeuThrAspArgIleAspAla-678 689-AsnLysLeuAlaArgTyrGluThrArgThrProGlyHis-701 707-GlyAlaAsnTyrArgArgAsnThrArgTyrGlyGluTrp-719 725-AlaAspAsnLeuLeu-729 739-PheLeuSerAspThrProGlnMetGlyArgSerPheThrGlyGlyVal-754 Hydrophilic Regions - Hopp-Woods 25-HisGlyThrGluGln-29 40-GlyLysSerArgProArgAlaThr-47 55-ThrAlaSerAspLysIleIleSer-62 64-AspThrLeuArgGlnLysAla-70 100-GlnThrGlyArgArgIleLysVal-107 112-GlyGluThrGlyAspMetAlaAspPheSerPro-122 157-AspValAlaAspGlyLysIleProGluLysMetProGluAsnGlyValSer-173 181-SerSerGlyAsnLeuGluLysLeuThr-189 207-GlyLeuTyrArgLysSerGlyAsp-214 219-ArgTyrArgAsnLeuLysArgLeuProAspSerHisAlaAspSerGlnThr-235 253-TyrSerAspArgArgAspGlnTyr-260 267-HisGluTyrAspAspCysHisAla-274 295-LeuThrGluGluAspIleAspTyrAspAsn-304 311-PheHisAspAspAspAspAlaHis-318 330-LeuArgAsnLysArgTyrGluLeuArgAlaGluTrp-341 354-HisLeuAsnArgAsnAspTyrArgHisAspGluLysAlaGlyAspAlaVal-370 378-ThrGlnAsnAlaArgIleGluLeuArgHis-387 391-GlyArgLeuLysGly-395 411-AlaThrSerGluAlaValLys-417 446-GlyGlyValArgValGluLysGlnLysAlaSerIleArgTyrAspLysAlaLeuIleAspArgGluAsnTyr -469 478-GlyAlaHisArgGlnThrAla-484 506-SerHisGlnGluArgLeuProSer-513 535-HisLeuAsnLysGluArgSerAsnAsn-543 550-TyrGluGlyAspArgTrp-555 575-LeuAsnAspGlyArgGlyProLysSerIleGluAspAspSerGluMetLysLeu-592 603-TyrGlyAlaGluGly-607 613-ProThrProArgTyrArgIle-619 624-AspTyrValArgGlyArgLeuLysAsn-632 637-ProGlyArgGluAspAlaTyrGly-644 652-AlaAspGlnAsnAlaProArgValProAla-661 671-SerLeuThrAspArgIleAspAla-678 690-LysLeuAlaArgTyrGluThrArgThrProGly-700 709-AsnTyrArgArgAsnThrArgTyrGly-717 al50 AMPHI Regions - AMPHI 1-MetGlnAsnThrAsnProProLeuProProMetProProGluIleThrGlnLeuLeuSerGlyLeuAspAlaAl aGlnTrpAlaTrpLeuSerGlyTyrAlaTrpAlaLysAlaGlyAsnGlyAlaSerAlaGlyLeuProAlaLeuGln ThrAlaLeuProThrAlaGluProPheSerValThrValLeuSerAlaSerGlnThrGlyAsnAlaLysSerValA laAspLysAlaAlaAspSerLeuGluAlaAlaGlylleGlnValSerArgAlaGluLeuLysAspTyrLysAlaLy sAsnlleAlaGlyGluArgArgLeuLeuLeuValThrSerThrGlnGlyGluGlyGluProProGluGluAlaVal ValLeuHisLysLeuLeuAsnGlyLysLysAlaProLysLeuAspLysLeuGlnPheAlaValLeuGlyLeuGlyA ΞpSerSerTyrProAsnPheCysArgAlaGlyLysAspPheAspLysArgPheGluGluLeuGlyAlaLysArgLe uLeuGluArgValAspAlaAspLeuAspPheAlaAlaAlaAlaAspGlyTrpThrAspAsnlleAlaAlaLeuLeu LysGluGluAlaAlaLysAsnArgAlaThrProAlaProGlnThrThrProProAlaGlyLeuGlnThrAlaProA spGlyArgTyrCysLysAlaAspProPheProAlaAlaLeuLeuAlaAsnGlnLysIleThrAlaArgGlnSerAs pLysAspValArgHisIleGluIleAspLeuSerGlySerAspLeuHisTyrLeuProGlyAspAlaLeuGlyVal TrpPheAspAsnAspProAlaLeuValArgGluIleLeuAspLeuLeuGlylleAspGlnAlaThrGluIleGlnA laGlyGlyLysThrLeuProValAlaSerAlaLeuLeuSerHisPheGluLeuThrGlnAsnThrProAlaPheVa lLysGlyTyrAlaProPheAlaAspAspAspGluLeuAspArglleAlaAlaAspAsnAlaValLeuGlnGlyPhe ValGlnSerThrProIleAlaAspValLeuHisArgPheProAlaLysLeuThrAlaGluGlnPheAlaGlyLeuL euArgProLeuAlaProArgLeuTyrSerlleSerSerSerGlnAlaGluValGlyAspGluValHisLeuThrVa lGlyAlaValArgPheGluHisGluGlyArgAlaArgAlaGlyGlyAlaSerGlyPheLeuAlaAspArgLeuGlu GluAspGlyThrValArgValPheValGluArgAsnAspGlyPheArgLeuProGluAspSerArgLysProIleV alMetlleGlySerGlyThrGlyValAlaProPheArgAlaPheValGlnGlnArgAlaAlaGluAsnAlaGluGl yLysAsnTrpLeuPhePheGlyAsnProHisPheAlaArgAspPheLeuTyrGlnThrGluTrpGlnGlnPheAla LysAspGlyPheLeuHisArgTyrAspPheAlaTrpSerArgAspGlnGluGluLysIleTyrValGlnAspLysI leArgGluGlnAlaGluGlyLeuTrpGlnTrpLeuGlnGluGlyAlaHisIleTyrValCysGlyAspAlaAlaLy sMetAlaLysAspValGluAlaAlaLeuLeuAspValllelleGlyAlaGlyHisLeuAspGluGluGlyAlaGlu GluTyrLeuAspMetLeuArgGluGluLysArgTyrGlnArgAspValTyr-599 Antigenic Index - Jameson-Wolf 1-MetGlnAsnThrAsnProProLeuProProMetProProGluIleThrGlnLeuLeuSerGlyLeuAspAlaAl aGlnTrpAlaTrpLeuSerGlyTyrAlaTrpAlaLysAlaGlyAsnGlyAlaSerAlaGlyLeuProAlaLeuGln ThrAlaLeuProThrAlaGluProPheSerValThrValLeuSerAlaSerGlnThrGlyAsnAlaLysSerValA laAspLysAlaAlaAspSerLeuGluAlaAlaGlylleGlnValSerArgAlaGluLeuLysAspTyrLysAlaLy sAsnlleAlaGlyGluArgArgLeuLeuLeuValThrSerThrGlnGlyGluGlyGluProProGluGluAlaVal ValLeuHisLysLeuLeuAsnGlyLysLysAlaProLysLeuAspLysLeuGlnPheAlaValLeuGlyLeuGlyA spSerSerTyrProAsnPheCysArgAlaGlyLysAspPheAspLysArgPheGluGluLeuGlyAlaLysArgLe uLeuGluArgValAspAlaAspLeuAspPheAlaAlaAlaAlaAspGlyTrpThrAspAsnlleAlaAlaLeuLeu LysGluGluAlaAlaLysAsnArgAlaThrProAlaProGlnThrThrProProAlaGlyLeuGlnThrAlaProA spGlyArgTyrCysLysAlaAspProPheProAlaAlaLeuLeuAlaAsnGlnLysIleThrAlaArgGlnSerAs pLysAspValArgHisIleGluIleAspLeuSerGlySerAspLeuHisTyrLeuProGlyAspAlaLeuGlyVal TrpPheAspAsnAspProAlaLeuValArgGluIleLeuAspLeuLeuGlylleAspGlnAlaThrGluIleGlnA laGlyGlyLysThrLeuProValAlaSerAlaLeuLeuSerHisPheGluLeuThrGlnAsnThrProAlaPheVa lLysGlyTyrAlaProPheAlaAspAspAspGluLeuAspArglleAlaAlaAspAsnAlaValLeuGlnGlyPhe ValGlnSerThrProIleAlaAspValLeuHisArgPheProAlaLysLeuThrAlaGluGlnPheAlaGlyLeuL euArgProLeuAlaProArgLeuTyrSerlleSerSerSerGlnAlaGluValGlyAspGluValHisLeuThrVa lGlyAlaValArgPheGluHisGluGlyArgAlaArgAlaGlyGlyAlaSerGlyPheLeuAlaAspArgLeuGlu GluAspGlyThrValArgValPheValGluArgAsnAspGlyPheArgLeuProGluAspSerArgLysProIleV alMetlleGlySerGlyThrGlyValAlaProPheArgAlaPheValGlnGlnArgAlaAlaGluAsnAlaGluGl yLysAsnTrpLeuPhePheGlyAsnProHisPheAlaArgAspPheLeuTyrGlnThrGluTrpGlnGlnPheAla LysAspGlyPheLeuHisArgTyrAspPheAlaTrpSerArgAspGlnGluGluLysIleTyrValGlnAspLysI leArgGluGlnAlaGluGlyLeuTrpGlnTrpLeuGlnGluGlyAlaHisIleTyrValCysGlyAspAlaAlaLy sMetAlaLysAspValGluAlaAlaLeuLeuAspValllelleGlyAlaGlyHisLeuAspGluGluGlyAlaGlu GluTyrLeuAspMetLeuArgGluGluLysArgTyrGlnArgAspValTyr-599 Hydrophilic Regions - Hopp-Woods 1-MetGlnAsnThrAsnProProLeuProProMetProProGluIleThrGlnLeuLeuSerGlyLeuAspAlaAl aGlnTrpAlaTrpLeuSerGlyTyrAlaTrpAlaLysAlaGlyAsnGlyAlaSerAlaGlyLeuProAlaLeuGln ThrAlaLeuProThrAlaGluProPheSerValThrValLeuSerAlaSerGlnThrGlyAsnAlaLysSerValA laAspLysAlaAlaAspSerLeuGluAlaAlaGlylleGlnValSerArgAlaGluLeuLysAspTyrLysAlaLy sAsnlleAlaGlyGluArgArgLeuLeuLeuValThrSerThrGlnGlyGluGlyGluProProGluGluAlaVal ValLeuHisLysLeuLeuAsnGlyLysLysAlaProLysLeuAspLysLeuGlnPheAlaValLeuGlyLeuGlyA spSerSerTyrProAsnPheCysArgAlaGlyLysAspPheAspLysArgPheGluGluLeuGlyAlaLysArgLe uLeuGluArgValAspAlaAspLeuAspPheAlaAlaAlaAlaAspGlyTrpThrAspAsnlleAlaAlaLeuLeu LysGluGluAlaAlaLysAsnArgAlaThrProAlaProGlnThrThrProProAlaGlyLeuGlnThrAlaProA spGlyArgTyrCysLysAlaAspProPheProAlaAlaLeuLeuAlaAsnGlnLysIleThrAlaArgGlnSerAs pLysAspValArgHisIleGluIleAspLeuSerGlySerAspLeuHisTyrLeuProGlyAspAlaLeuGlyVal TrpPheAspAsnAspProAlaLeuValArgGluIleLeuAspLeuLeuGlylleAspGlnAlaThrGluIleGlnA laGlyGlyLysThrLeuProValAlaSerAlaLeuLeuSerHisPheGluLeuThrGlnAsnThrProAlaPheVa lLysGlyTyrAlaProPheAlaAspAspAspGluLeuAspArglleAlaAlaAspAsnAlaValLeuGlnGlyPhe ValGlnSerThrProIleAlaAspValLeuHisArgPheProAlaLysLeuThrAlaGluGlnPheAlaGlyLeuL euArgProLeuAlaProArgLeuTyrSerlleSerSerSerGlnAlaGluValGlyAspGluValHisLeuThrVa lGlyAlaValArgPheGluHisGluGlyArgAlaArgAlaGlyGlyAlaSerGlyPheLeuAlaAspArgLeuGlu GluAspGlyThrValArgValPheValGluArgAsnAspGlyPheArgLeuProGluAspSerArgLysProIleV alMetlleGlySerGlyThrGlyValAlaProPheArgAlaPheValGlnGlnArgAlaAlaGluAsnAlaGluGl yLysAsnTrpLeuPhePheGlyAsnProHisPheAlaArgAspPheLeuTyrGlnThrGluTrpGlnGlnPheAla LysAspGlyPheLeuHisArgTyrAspPheAlaTrpSerArgAspGlnGluGluLysIleTyrValGlnAspLysI leArgGluGlnAlaGluGlyLeuTrpGlnTrpLeuGlnGluGlyAlaHisIleTyrValCysGlyAspAlaAlaLy sMetAlaLysAspValGluAlaAlaLeuLeuAspValllelleGlyAlaGlyHisLeuAspGluGluGlyAlaGlu GluTyrLeuAspMetLeuArgGluGluLysArgTyrGlnArgAspValTyr-599 al51 AMPHI Regions - AMPHI 6-AsnIleAlaIleIleAla-ll 22-AspGlnLeuLeuArg-26 72-ValAspThrProGlyHis-77 81-GlyGlyGluValGluArgValLeuGlyMetValAspCysVal-94 128-LysIleAspLysPro-132 144-PheGluLeuPheAspAsnLeuGlyAlaThr-153 165-SerGlyLeuSerGlyPheAlaLysLeuGluGluThrAspGluSerAsn-180 184-ProLeuPheAspThrIleLeuLysTyrThr-193 248-GlyArgIleAsnGlnLeuLeuGlyPheLysGlyLeuGluArgVal-262 273-ValIleIleSerGlyIleGlu-279 330-IleArgAspArgLeuGlnLysGluLeu-338 348-AspThrAlaAspAla-352 396-CysGluProTyrGluAsnLeuThrValAsp-405 457-LeuThrArgGlyValGly-462 464-MetSerHisValPheAsp-469 537-LysGlyLysLysLeuThrAsnIle-544 551-GluAlaValArgLeuThrThr-557 Antigenic Index - Jameson-Wolf l-MetLysGlnIleArg-5 13-ValAspHisGlyLysThrThrLeu-20 24-LeuLeuArgGlnSerGlyThrPheArgAlaAsnGlnGlnValAspGluArgValMetAspSerAsnAspLeuG luLysGluArgGlyIle-53 59-AsnThrAlaIleAspTyrGluGlyTyr-67 72-ValAspThrProGlyHisAlaAspPheGlyGlyGluValGluArg-86 99-AspAlaGlnGluGlyProMetProGlnThrArgPheValThr-112 128-LysIleAspLysProSerAlaArgProSerTrp-138 151-GlyAlaThrAspGluGlnLeuAsp-158 171-AlaLysLeuGluGluThrAspGluSerAsnAspMetArgProLeu-185 193-ThrProAlaProSerGlySerAlaAspGluThrLeu-204 211- euAspTyrAspAsnTyrThrGly-218 226-LeuAsnGlyArgIleLysProGlyGln-234 240-AsnHisAspGlnGlnIleAla-246 257-LysGlyLeuGluArgValProLeuGluGluAlaGluAlaGlyAsp-271 277-GlyIleGluAspIleGly-282 287-IleThrAspLysAspAsnProLysGlyLeuPro-297 300-SerValAspGluProThrLeu-306 314-ThrSerProLeuAlaGlyThrGluGlyLysPheValThrSerArgGlnIleArgAspArgLeuGlnLysGlu LeuLeu-339 344-LeuArgValGluAspThrAlaAspAlaAspValPheArgValSerGlyArgGlyGluLeu-363 371-AsnMetArgArgGluGlyTyr-377 381-ValGlyLysProArgValValTyrArgAspIleAspGlyGlnLysCysGluProTyrGluAsnLeuThrVal AspValProAspAspAsnGlnGlyAlaValMetGluGluLeuGlyArgArgArgGlyGluLeuThrAsnMetGluS erAspGlyAsnGlyArgThrArgLeuGluTyr-440 467-ValPheAspAspTyrAlaProValLysProAspMetProGlyArgHisAsnGly-484 489-GlnGluGlnGlyGlu-493 501-AsnLeuGluAspArgGlyArgMetPheValSerProAsnAspLysI1eTyr-517 524-IleHisSerArgAspAsnAspLeu-531 535-ProLeuLysGlyLysLysLeuThrAsnIleArgAlaSerGlyThrAspGluAlaValArg-554 569-PheIleAspAspAspGluLeuValGlu-577 579-ThrProGlnSerIleArgLeuArgLysArgTyrLeuSerGluLeuGluArgArgArgHisPheLysLysLeu Asp-603 Hydrophilic Regions - Hopp-Woods l-MetLysGlnIleArg-5 29-GlyThrPheArgAla-33 35-GlnGlnValAspGluArgValMetAspSerAsnAspLeuGluLysGluArgGlyIle-53 80-PheGlyGlyGluValGluArg-86 99-AspAlaGlnGluGlyProMetPro-106 128-LysIleAspLysProSerAla-134 151-GlyAlaThrAspGluGlnLeuAsp-158 171-AlaLysLeuGluGluThrAspGluSerAsnAspMetArgProLeu-185 198-GlySerAlaAspGluThrLeu-204 226-LeuAsnGlyArgIleLysPro-232 241-HisAspGlnGlnIleAla-246 258-GlyLeuGluArgValProLeuGluGluAlaGluAlaGlyAsp-271 277-GlyIleGluAspIleGly-282 287-IleThrAspLysAspAsnProLysGly-295 300-SerValAspGluProThrLeu-306 318-AlaGlyThrGluGlyLysPheValThr-326 328-ArgGlnlleArgAspArgLeuGlnLysGluLeuLeu-339 344-LeuArgValGluAspThrAlaAspAlaAspValPheArgValSerGlyArgGlyGluLeu-363 371-AsnMetArgArgGluGlyTyr-377 381-ValGlyLysProArgValValTyrArgAspIleAspGlyGlnLysCysGluProTyrGlu-400 405-AspValProAspAspAsnGlnGlyAlaValMetGluGluLeuGlyArgArgArgGlyGluLeuThrAsnMet GluSerAspGlyAsnGlyArgThrArgLeu-438 472-AlaProValLysProAspMetProGlyArgHis-482 489-GlnGluGlnGlyGlu-493 502-LeuGluAspArgGlyArgMet-508 512-ProAsnAspLysIleTyr-517 525-HisSerArgAspAsnAspLeu-531 536-LeuLysGlyLysLysLeuThrAsn-543 545-ArgAlaSerGlyThrAspGluAlaValArg-554 569-PheIleAspAspAspGluLeuValGlu-577 583-IleArgLeuArgLysArgTyrLeuSerGluLeuGluArgArgArgHisPheLysLysLeuAsp-603 al52 AMPHI Regions - AMPHI 10-PheProThrArgLeuPhe-15 66-ArgPheSerArgPheValArgGlyTrpSerGlyIleArgGluTyrMetLysAsnGlyIleProGluHisValG lnProGlyHisAsnProLeu-96 103-AlaLeuLeuAlaAla-107 130-LeuAsnHisLeuValSerGluHisThrGlySerLeu-141 150-PheLysLeuLeuAlaValPheSerAlaValHisIleAlaXxxValAlaAlaTyr-167 Antigenic Index - Jameson-Wolf l-MetLysAsnLysThrLysValTrp-8 28-TyrSerAlaLysThrGlyGlyAsp-35 61-GlySerAspThrAlaArgPhe-67 74-TrpSerGlyIleArgGluTyrMetLysAsnGlyIleProGluHisValGlnProGlyHisAsnProLeu-96 125-SerThrAsnGlyTyr-129 137-HisThrGlySerLeuMetArg-143 169-ValPheLysLysLysAsnLeu-175 186-IleGluGlyLysThrSerIle-192 Hydrophilic Regions - Hopp-Woods l-MetLysAsnLysThrLysVal-7 63-AspThrAlaArgPhe-67 78-ArgGluTyrMetLys-82 169-ValPheLysLysLysAsnLeu-175 186-IleGluGlyLysThrSerIle-192 al53 AMPHI Regions - AMPHI 17-AlaAlaSerValLeuSerLeuProGluMetMetArgLeuMetValPhe-32 96-ThrLeuValAlaTyrIleLysLeuSerSerValAlaGlu-108 130-ValSerValProGlnHisTrp-136 222-ValAsnThrIleLeuAsnGlyIleAlaTyr-231 274-AlaLysLysLeuSerHisLeuTyrArgIleThrGluAlaValGlyArgTrpSerMetIleAspIlePheVal Ile-298 Antigenic Index - Jameson-Wolf 65-IleArgLysGlnAla-69 81-ValArgLeuArgGln-85 107-AlaGluValArgPhe-lll 143-ArgLeuThrGlyAspAsnAlaValGlnThrAlaSerGluGlyLysThrCysCysSer-161 165-TyrPheArgAspSerAlaGluSerProCysGly-175 180-GluLeuTyrArgArgArgProLysSerLeuSer-190 215-SerAsnProAlaAlaThr-220 234-AspGluGlyAspArgLeu-239 272-ThrGlyAlaLysLysLeu-277 339-LeuLeuTrpAspLysArgAlaSerAspGlyIleAla-350 352-AsnGluThrGluLysHisAsp-358 Hydrophilic Regions - Hopp-Woods 81-ValArgLeuArgGln-85 107-AlaGluValArgPhe-lll 152-ThrAlaSerGluGlyLysThrCysCys-160 168-AspSerAlaGluSerPro-173 180-GluLeuTyrArgArgArgProLysSerLeuSer-190 234-AspGluGlyAspArgLeu-239 273-GlyAlaLysLysLeu-277 339-LeuLeuTrpAspLysArgAlaSerAsp-347 352-AsnGluThrGluLysHisAsp-358 al54 AMPHI Regions - AMPHI 122-GlyValThrGlyLeuGlyThrLeuLeu-130 152-GlnAspIleProProValThr-158 262-ThrLysAsnSerLysAsnValLysΞer-270 298-PheLysGlnSerVal-302 360-SerLysGluHisTrpLysGlnGlnPheGlnThrAlaLeuAsnLysGlyLeuThrAla-378 389-SerLysMetIleGluLeuAsnAsp-396 429-LysLeuAlaAspLeuLeuAspLysPheAspLysLeuPro-441 446-ValAlaGluLeuAsnGly-451 467-LeuSerSerIleAspLysLeuValGlyLysProGlnThrGlnAsnIleProAsnGluLeuAsnGlnThrLeu LysGluLeuArgThrThr-496 506-IleTyrGlyAspValGlnAsnThrLeuGlnSerLeuAspLysThrLeuLysAspValGlnProValIleAsn ThrLeuLysGluLys-534 Antigenic Index - Jameson-Wolf l-MetThrAspAsnSerProProProAsnGlyHisAlaGlnAlaArgValArgLysAsnAsnThr-21 43-LysGluIleArgAsnArgGlyProVal-51 57-AspSerAlaGluGlyIleGluValAsnAsnThr-67 75-AspValGlyArgValThrArgIleLysLeuArgAspAspGlnLysGlyValGlu-92 100-AspValSerGlyLeuIleArgSerAspThrGln-llO 114-ValLysProArgIleAspGlnSerGly-122 138-ThrProGlyLysSerAspGluAlaLysAspValPheGln-150 169-LeuIleGlyLysAsnAspArgIleLeuAsn-178 196-AlaHisPheAspProSerAspGlnSer-204 212-GlnSerProAsnAspLysLeuIle-219 228-GluSerGlyIleAsnIleGluThrThrGlySerGlyIleLysLeuAsnSer-244 256-SerPheAspSerProLysThrLysAsnSerLysAsnValLysSerGluAspSer-273 275-ThrLeuTyrAspSerArgSerGluValAlaAsnLeuProAspAspArgSerLeu-292 300-GlnSerValArgGlyLeu-305 311-ValGluTyrLysGlyLeuAsn-317 325-ProTyrPheAspArgAsnAspSer-332 345-IleArgIleGluProSerArgLeuGluIleAsnAlaAspGluGlnSerLysGluHisTrpLysGlnGlnPhe -368 371-AlaLeuAsnLysGlyLeu-376 386-LeuThrGlySerLysMetIleGluLeuAsnAspGlnProSerAlaSerProLysLeuArgPro-406 419-GlnGlyGlyGlyLeuAspAspLeuGlnValLysLeu-430 432-AspLeuLeuAspLysPheAspLysLeuProLeuAspLysThrValAla-447 450-AsnGlySerLeuAlaGluLeuLysSerThrLeuLysSerAlaAsn-464 469-SerIleAspLysLeuValGlyLysProGlnThrGlnAsnIleProAsnGluLeuAsnGlnThrLeuLysGlu LeuArgThrThr-496 500-ValSerProGlnSer-504 516-SerLeuAspLysThrLeuLysAspValGln-525 530-ThrLeuLysGluLysProAsn-536 541-AsnSerSerSerLysAspProIleProLysGlySerArg-553 Hydrophilic Regions - Hopp-Woods l-MetThrAspAsnSerProProPro-8 12-AlaGlnAlaArgValArgLysAsnAsn-20 43-LysGluIleArgAsnArgGly-49 57-AspSerAlaGluGlyIleGlu-63 75-AspValGlyArgValThrArgIleLysLeuArgAspAspGlnLysGlyValGlu-92 105-IleArgSerAspThr-109 116-ProArgIleAspGln-120 140-GlyLysSerAspGluAlaLysAspValPheGln-150 171-GlyLysAsnAspArgIleLeu-177 196-AlaHisPheAspProSerAspGln-203 214-ProAsnAspLysLeuIle-219 258-AspSerProLysThrLysAsnSerLysAsnValLysSerGluAspSer-273 278-AspSerArgSerGluVal-283 285-AsnLeuProAspAspArgSer-291 311-ValGluTyrLysGly-315 328-AspArgAsnAspSer-332 345-IleArgIleGluProSerArgLeuGluIleAsnAlaAspGluGlnSerLysGluHisTrpLys-365 390-LysMetIleGluLeuAsnAspGlnProSerAlaSerProLysLeuArgPro-406 421-GlyGlyLeuAspAspLeuGlnValLysLeu-430 432-AspLeuLeuAspLysPheAspLysLeuProLeuAspLysThrValAla-447 54-AlaGluLeuLysSerThrLeuLysSerAlaAsn-464 469-SerIleAspLysLeuValGly-475 482-IleProAsnGluLeu-486 488-GlnThrLeuLysGluLeuArgThr-495 516-SerLeuAspLysThrLeuLysAspValGln-525 530-ThrLeuLysGluLysProAsn-536 543-SerSerLysAspProIleProLysGlySerArg-553 al55 AMPHI Regions - AMPHI 28-LysLeuGlyPheGlu-32 42-AlaAlaSerLeuAsp-46 105-LeuArgAlaLysLysVal-110 118-ValProArgIleSerArgAlaGlnAlaLeuAspXxxLeuSerXxxMetAlaAsnIleSerGlyTyrArgAla ValIleGluAlaAlaAsnAlaPheGlyArgXxxPheThrGlyGlnIleThrAlaAlaGly-161 175-ValAlaGlyLeuAlaAlaIleGlyThrAlaAsnSerLeuGlyAlaValValArgValPhe-194 201-AlaGluGlnLeuGluSerMetGlyGly-209 225-AspGlyTyrAlaLysValMet-231 264-AlaProLysXxxXxxXxxLysGluMetValGluSerMetLys-277 281-ValIleValAspLeu-285 307-GlyValLysIleIleGlyTyrThrAspMetAlaAsnArgLeuAlaGlyGln-323 330-ThrAsnLeuValAsnLeuThrLysLeuLeuSer-340 404-LysLeuAlaProAlaXxxIle-410 428-AsnHisPheIleVal-432 451-LeuHisThrProLeuMetSerValThrAsnAlaIleSerGlyIleIle-466 469-GlyAlaLeuLeuGln-473 478-AsnGlyPheValSerLeuLeuSerPheValAla-488 494-IleAsnIlePheGlyGly-499 Antigenic Index - Jameson-Wolf 4-GlyIleProArgGluSerLeuSerGlyGluThrArgVal-16 44-SerLeuAspAspAlaAla-49 72-ValAsnAlaProSerGluAspGluLeuProLeuLeuLysGluGlyGln-87 94-TrpProArgGlnAsnGluAlaLeu-101 105-LeuArgAlaLysLysValAsn-lll 117-MetValProArgIleSerArg-123 159-AlaAlaGlyLysValProProAla-166 202-GluGlnLeuGluSerMetGlyGlyLys-210 215-AspPheProGlnGluSerGlyGlySerGlyAspGlyTyrAlaLysValMetSer-232 242-LeuPheAlaGluGlnAlaLysGluValAsp-251 259-IleProGlyLysProAlaProLysXxxXxxXxxLysGluMetValGluSerMetLysProGlySer-280 290-GlyGlyAsnCysGluLeuThrLysGlnGlyGlu-300 320-LeuAlaGlyGlnSerSer-325 338-LeuLeuSerProAsnLysAspGlyGluIle-347 349-LeuAspPheGluAspValIle-355 360-ThrValThrArgAspGlyGluIleThrPhePro-370 378-AlaGlnProGlnGlnThrProSerGluLysAlaAlaProAlaAlaLysProGluProLysPro-398 509-MetPheArgLysGly-513 Hydrophilic Regions - Hopp-Woods 4-Glyl1eProArgGluSerLeuSerGlyGluThrArgVal-16 44-SerLeuAspAspAlaAla-49 74-AlaProSerGluAspGluLeuProLeuLeuLysGluGlyGln-87 96-ArgGlnAsnGluAlaLeu-101 105-LeuArgAlaLysLysValAsn-lll 117-MetValProArgIleSerArg-123 202-GluGlnLeuGluSerMetGly-208 215-AspPheProGlnGluSerGlyGlySerGlyAspGlyTyrAla-228 242-LeuPheAlaGluGlnAlaLysGluValAsp-251 260-ProGlyLysProAlaProLysXxxXxxXxxLysGluMetValGluSerMetLysPro-278 291-GlyAsnCysGluLeuThrLysGlnGlyGlu-300 340-SerProAsnLysAspGlyGluIle-347 349-LeuAspPheGluAspValIle-355 360-ThrValThrArgAspGlyGluIle-367 382-GlnThrProSerGluLysAlaAlaProAlaAlaLysProGluProLysPro-398 al56 AMPHI Regions - AMPHI 56-AsnGlyPheGluAlaPheAlaProPhe-64 80-AlaThrValAsnThr-84 Antigenic Index - Jameson-Wolf 21-TyrAlaLysLysAlaGlyGlyPheArgPheLysAspAsnHisAsnProArgAspPheLeuAlaArgThrGlnG lyThrAlaAlaArgAlaHisAlaAlaGlnGlnAsnGlyPheGlu-59 73-AlaThrGlyAsnAlaGlyGln-79 103-AspLysAlaAlaLeu-107 Hydrophilic Regions - Hopp-Woods 21-TyrAlaLysLysAlaGlyGlyPheArgPheLysAspAsnHisAsnProArgAspPheLeuAla-41 43-ThrGlnGlyThrAlaAlaArgAlaHisAla-52 103-AspLysAlaAlaLeu-107 al57 AMPHI Regions - AMPHI 10-ArgArgGluLeuArgArgAla-16 32-11eAsnArgLeuLeuLysArgTyr11eLysArgGly-43 61-PheValArgAlaAlaGln-66 137-LeuGlyGlnAlaGlyGly-142 167-GlnPheValAspArgLeuProArgGluProHisAspLeuLeuLeuAspGly-183 Antigenic Index - Jameson-Wolf 1-MetArgAsnGluGluLysHisAlaLeuArgArgGluLeuArgArgAlaArgAlaGlnMetGlyHisGlnGlyAr gLeuAlaAla-28 34-ArgLeuLeuLysArgTyrIleLysArgGlyArgLysIle-46 51-ProMetGlyLysGluLeuArgLeuAspGlyPheVal-62 64-AlaAlaGlnLysArgGlyAlaLysLeu-72 77-IleGluProArgSerArgArgMetTrp-85 88-ProTyrProGluSerGlyMetGluArgGluArgIleArgGlyArgAlaLysLeuAsnVal-107 110-PheAlaGlyArgLysIleArgVal-117 129-GlyIleAspArgGluGlyTyrArgLeuGlyGln-139 153-TyrArgLeuGlnAla-157 168-PheValAspArgLeuProArgGluProHisAspLeuLeuLeu-181 Hydrophilic Regions - Hopp-Woods l-MetArgAsnGluGluLysHisAlaLeuArgArgGluLeuArgArgAlaArgAlaGlnMet-20 34-ArgLeuLeuLysArgTyr11eLysArgGlyArgLys11e-46 54-LysGluLeuArgLeu-58 64-AlaAlaGlnLysArgGlyAla-70 77-IleGluProArgSerArgArg-83 92-SerGlyMetGluArgGluArgIleArgGlyArgAlaLysLeu-105 lll-AlaGlyArgLysIleArgVal-117 129-GlyIleAspArgGluGlyTyrArg-136 153-TyrArgLeuGlnAla-157 170-AspArgLeuProArgGluProHisAspLeuLeu-180 al58 AMPHI Regions - AMPHI 20-PheSerArgAlaAlaGluGlnLeu-27 33-AlaValSerArgIleValLysArgLeuGlu-42 46-GlyValAsnLeuLeuAsnArgThr-53 63-GlyAlaGlnTyrPheArgArgAlaGlnArgIleLeuGlnGlu-76 85-LeuAlaValHisGluIleProGln-92 166-ValIleAlaSerPro-170 178-ThrProGlnSerThrGluGluLeu-185 188-HisGlnCysLeuGlyPheThrGluProGlySerLeuAsnThrTrpAlaVal-204 Antigenic Index - Jameson-Wolf l-MetLysThrAsnSerGluGluLeu-8 16-GluSerGlySerPheSerArgAlaAlaGlu-25 36-ArgIleValLysArgLeuGluGluLysLeuGly-46 49-LeuLeuAsnArgThrThrArgGlnLeuSerLeuThrGluGluGlyAlaGlnTyrPheArgArgAlaGlnArgI leLeuGln-75 78-AlaAlaAlaGluThrGluMet-84 90-IleProGlnGlyValLeuArgValAspSer-99 114-LysPheAsnGluArgTyrProHisIleArg-123 136-IleGluArgLysValAspIle-142 144-LeuArgAlaGlyGluLeuAspAspSerGlyLeuArgAla-156 158-HisLeuPheAspSerArgPheArgVal-166 168-AlaSerProGluTyrLeuAlaLysHisGlyThrProGlnSerThrGluGluLeuAla-186 192-GlyPheThrGluProGlySerLeuAsn-200 207-AlaGlnGlyAsnProTyrLysIle-214 216-ProHisPheThrAlaSerSerGlyGluIleLeu-226 229-LeuCysLeuSerGlyCysGly-235 243-LeuValAspAsnAspIleAlaGluGlyLysLeu-253 258-AlaGluGlnThrSerAsnLysThrHisProPhe-268 273-TyrSerAspLysAlaValAsnLeu-280 292-GluLeuGlyAsnAsnLeuCysGly-299 Hydrophilic Regions - Hopp-Woods l-MetLysThrAsnSerGluGluLeu-8 19-SerPheSerArgAlaAlaGlu-25 36-ArgIleValLysArgLeuGluGluLysLeuGly-46 58-SerLeuThrGluGluGlyAlaGlnTyrPheArgArgAlaGlnArgIleLeuGln-75 78-AlaAlaAlaGluThrGluMet-84 95-LeuArgValAspSer-99 114-LysPheAsnGluArgTyrPro-120 136-IleGluArgLysValAspIle-142 144-LeuArgAlaGlyGluLeuAspAspSerGlyLeuArgAla-156 162-SerArgPheArgVal-166 180-GlnSerThrGluGluLeuAla-186 246-AsnAspIleAlaGluGlyLysLeu-253 260-GlnThrSerAsnLysThrHis-266 276-LysAlaValAsnLeu-280 al60 AMPHI Regions - AMPHI 6-LysLeuValAspPheAlaGlnLeuThrGly-15 72-GlyLeuGlyHisVal-76 121-AlaAspLeuMetAsnGlyLeuProGluThr-130 157-GlyThrValSerMetValAsnAlaLeuSerSer-167 186-LeuSerGlyValLeuLysGlyTrpGlnAspLysArg-197 200-HisLeuIleGlnLysValIleAspLysProGlu-210 218-MetValAlaAlaAlaAsn-223 229-LeuMetArgArgPhe-233 242-HisAlaPheValAsnHisIleArg-249 279-PheGlyLysAlaPheLys-284 Antigenic Index - Jameson-Wolf 2-AsplleLeuAspLysLeuVal-8 28-SerValArgHisGluThrLeuGlnArgGluGlyLeu-39 51-CysIleAspGlyGluThrSerProArgProValSerThrGlyAsp-65 77-LeuSerHisAspGlyLysCysGlyGluSerLeuGlnProAspMetArgGlnHisGly-95 101-GlnCysGlyAsnGlyGlnAspMet-108 115-PheArgTyrAspThrHisAla-121 123-LeuMetAsnGlyLeu-127 149-LeuGluSerLysLysProLeu-155 178-LeuGluGlnAspLysAspValGluLeu-186 192-GlyTrpGlnAspLysArgLeuGly-199 205-ValIleAspLysProGluAspGluTrpAsnValAspLysMetVal-219 228-GlnLeuMetArgArgPheLysSerArgValGlyLeuSerProHis-242 255-LeuLeuLeuLysLysAsnProAspSerVal-264 274-GlnSerGluThrHisPhe-279 281-LysAlaPheLysArg-285 290-SerProGlyGlnTyrArgLysGluGlyGlyGlnLys-301 Hydrophilic Regions - Hopp-Woods 2-Aspl1eLeuAspLysLeuVal-8 29-ValArgHisGluThrLeuGlnArgGluGlyLeu-39 53-AspGlyGluThrSerProArgProValSer-62 79-HisAspGlyLysCysGlyGluSerLeuGlnProAspMetArgGln-93 101-GlnCysGlyAsnGlyGlnAsp-107 149-LeuGluSerLysLysProLeu-155 178-LeuGluGlnAspLysAspValGluLeu-186 193-TrpGlnAspLysArgLeuGly-199 205-ValIleAspLysProGluAspGluTrpAsnVal-215 228-GlnLeuMetArgArgPheLysSerArgValGly-238 255-LeuLeuLeuLysLysAsnProAspSer-263 281-LysAlaPheLysArg-285 293-GlnTyrArgLysGluGlyGlyGlnLys-301 al63 AMPHI Regions - AMPHI 60-SerSerLeuGlyAsnIle-65 67-LeuGlyArgAspGluAsp-72 76-PheGlyPheLeuSerTrpLeuAlaMetLeuPhe-86 100-AlaGluProLeuMetHisTyrPheSerAspIleThrAla-112 170-IleSerGlyArgPheGlyAspAlaIleAspIleMetAlaLeuLeuAlaThrPhePheGlyIleIleThrThr -193 227-MetSerLeuAlaValValSerAlaIleSerGlyValGlyLysGlyValLysValLeuSer-246 272-AlaPheGlyAspAsnIleGlyAsnTyrLeuGlyAsnLeuValArg-286 313-TrpCysSerTrpAlaProPheValGlyLeuPheIleAla-325 346-LeuPheGlyValLeuTrpPhe-352 367-AlaGlyGlyValLeuGluLysMetThrSerSer-377 380-ThrLeuLeuPheLysPhePheAsnTyrLeuProLeuProGluLeuThrSerIleValSerLeuLeu-401 438-TrpGlyValLeuMetSerAla-444 454-GlyLeuGlyAsnLeuGlnSerMetThrLeu-463 520-GluGlnAspIleLeuLysPheLeuLysHisThrAla-531 535-MetHisGluLeuGlnArgGluLeu-542 574-AspPheMetTyrGlyIle-579 583-GlyGlnAspValSerAspGlnLeu-590 63 O-AlaAspIleLeuLysAsnTyr-636 Antigenic Index - Jameson-Wolf 29-AspArgAlaLysGlu-33 65-IleArgLeuGlyArgAspGluAspValPro-74 lll-ThrAlaGlyThrProGluHisArgGlnGln-120 166-LeuLysGluLysIleSerGlyArgPheGlyAspAlaIleAsp-179 200-GlnLeuGlyAlaGlyLeu-205 237-GlyValGlyLysGlyValLysVal-244 293-AlaTyrGluArgGluHisLysProTrpPhe-302 326-ArgIleSerLysGlyArgThrIleArg-334 370-ValLeuGluLysMetThrSerSerProGluThr-380 409-ThrSerAlaAspSerGlyIle-415 421-IleThrSerArgAspLysGlyLeuSerAlaProArgTrp-433 451-ArgSerGlyGlyLeuGlyAsn-457 484-LeuSerAlaAspLysLysTyrPheGluThrArgValAsnProThrSer-499 503-ThrGlyGlyLysTrpLysGluArgLeu-511 516-SerGlnThrGlnGluGlnAspIle-523 537-GluLeuGlnArgGluLeuΞerGluGluTyrGlyLeu-548 550-ValArgValAspLysMetPheHisGlnAspGluProAla-562 566-ValIleArgLysGluThrMetArg-573 581-SerValGlyGlnAspValSerAspGlnLeuIleAsnAspGlyLysLeuProHisIleArgHisGlnThrThr TyrLysProTyr-608 612-PheAspGlyArgValGlyTyr-618 622-TyrMetAsnLysAspGluLeuIle-629 632-IleLeuLysAsnTyrGlu-637 654-GluGlnValGluLeuAlaGlu-660 Hydrophilic Regions - Hopp-Woods 29-AspArgAlaLysGlu-33 66-ArgLeuGlyArgAspGluAspValPro-74 114-ThrProGluHisArgGlnGln-120 166-LeuLysGluLysIleSerGlyArgPheGlyAsp-176 238-ValGlyLysGlyValLysVal-244 293-AlaTyrGluArgGluHisLysPro-300 327-IleSerLysGlyArgThrIleArg-334 370-ValLeuGluLysMetThrSerSerPro-378 422-ThrSerArgAspLysGlyLeuSer-429 484-LeuSerAlaAspLysLysTyrPheGlu-492 506-LysTrpLysGluArgLeu-511 517-GlnThrGlnGluGlnAspIle-523 537-GluLeuGlnArgGluLeuSerGluGluTyrGlyLeu-548 550-ValArgValAspLysMetPheHisGlnAspGluProAla-562 566-ValIleArgLysGluThrMetArg-573 581-SerValGlyGlnAspValSerAsp-588 590-LeuIleAsnAspGlyLysLeuProHis-598 622-TyrMetAsnLysAspGluLeuIle-629 654-GluGlnValGluLeuAlaGlu-660 al64 AMPHI Regions - AMPHI 6-AlaAsnPheTyrGluMetLeuThrAlaAla-15 33-AlaTyrArgAlaLeuLysGlnGlu-40 75-AlaValSerAlaIleGlyAlaVal-82 97-TyrIleLeuAsnAspCys-102 113-LeuSerLysGluLeuAlaGlyLeuLysAla-122 148-PheGluAspValArgArgPheProGlu-156 160-LeuGlyArgGlnProArgIleAsnAspLeuAlaHis-171 189-TyrAlaAsnLeuPheAlaAsnLeuAsnGlyIleGluArgIlePheLys-204 264-ValProAlaIleTyrThr-269 282-TrpPheAsnArgIle-286 311-AlaLysLeuLeuGluGlyTyrGlyLeuSer-320 362-GluValGlyGluLeuIle-367 374-MetArgGlyTyrLeuAsn-379 387-ThrIleValAsnGlyTrpLeuLys-394 424-ValTyrProArgGluIleGluGluGlu-432 459-PheValGlnLeuLysGluGlyMet-466 472-GluIleArgArgHisLeuArgThrVal-480 484-PheLysIleProLysGln-489 499-AsnAlaThrGlyLysValLeuLysArgValLeuLysGluGlnPheAspGlyAsn-516 Antigenic Index - Jameson-Wolf 1-MetAsnArgThrTyr-5 15-AlaCysArgLysAsnGlyAsnGly-22 26-PheAspGlyLysGluLysThrAlaTyrArgAlaLeuLysGlnGluAlaGluAla-43 63-ValSerAsnSerThrGlu-68 88-ThrPheLeuLysAsnSerGlu-94 lOO-AsnAspCysLysAla-104 112-GlyLeuSerLysGluLeuAlaGly-119 121-LysAlaGlnThrProValGlu-127 133-GlyGlnSerArgProAspGlyGluMetAlaGluGlyAspAlaPhePheGluAspValArgArgPheProGlu LysProAspLeuGlyArgGlnProArgIleAsnAsp-168 176-SerGlyThrThrGlyHisProLysGlyAla-185 196-LeuAsnGlyIleGluArgIlePheLysIleSerLysArgAspArgPhe-211 270-AlaMetSerLysThrLysIle-276 291-SerGlyGlyAlaProLeuAla-297 304-PheLysAlaLysPheProArg-310 317-TyrGlyLeuSerGluAlaSer-323 330-ThrProGluArgGlnLysAlaArgSer-338 343-LeuProGlyLeuGluValLysAlaValAspGluGluLeuValGluValProArgGlyGluValGly-364 367-IleValArgGlyGlySerValMet-374 382-AlaAlaThrAspGluThrIle-388 393-LeuLysThrGlyAsp-397 400-ThrIleAspGluAspGly-405 410-ValAspArgLysLysAspLeuIleIleSerLysGlyGlnAsnValTyrProArgGluIleGluGluGluIle TyrLys-435 446-GlyValLysAspArgTyrAlaAspGluGluIle-456 462-LeuLysGluGlyMetAspLeuGlyGluAsnGluIleArgArgHisLeuArg-478 490-IleHisPheLysAspGlyLeuProArgAsnAlaThrGlyLysValLeuLysArgValLeuLysGluGlnPhe AspGlyAsnLys-517 Hydrophilic Regions - Hopp-Woods 15-AlaCysArgLysAsnGlyAsn-21 26-PheAspGlyLysGluLysThrAlaTyrArgAlaLeuLysGlnGluAlaGluAla-43 112-GlyLeuSerLysGluLeuAlaGly-119 135-SerArgProAspGlyGluMetAlaGluGlyAspAlaPhePheGluAspValArgArgPheProGluLysPro AspLeuGlyArgGlnProArgl1eAsnAsp-168 198-GlyIleGluArgIlePheLysIleSerLysArgAspArgPhe-211 304-PheLysAlaLysPheProArg-310 330-ThrProGluArgGlnLysAlaArgSer-338 346-LeuGluValLysAlaValAspGluGluLeuValGluValProArgGlyGluValGly-364 382-AlaAlaThrAspGluThrIle-388 400-ThrIleAspGluAspGly-405 410-ValAspArgLysLysAspLeuIleIle-418 425-TyrProArgGluIleGluGluGluIleTyrLys-435 446-GlyValLysAspArgTyrAlaAspGluGluIle-456 462-LeuLysGluGlyMetAspLeuGlyGluAsnGluIleArgArgHisLeuArg-478 494-AspGlyLeuProArgAsnAlaThr-501 503-LysValLeuLysArgValLeuLysGluGlnPheAspGlyAsnLys-517 al65-l AMPHI Regions - AMPHI 17-AlaThrLeuGlyValLeuLeuLysGluLeu-26 33-ThrLeuIleGluArgLeuGluAsp-40 72-IleIleAspProAlaArgAlaLeuAsnIleAla-82 90-GlnPheTrpAlaThr-94 108-AsnAlaValProHis-112 125-LeuGlnLysArgTyrAspAlaPheLysThrGlnLysLeuPheGluAsnMet-141 182-ArgLeuThrArgGlnMetValLysTyrLeuGlnGly-193 198-ThrGluPheAsnArgHisValGluAspIleLysArgGlu-210 364-LysThrLysGluGlu-368 371-AlaSerLeuLeuGluTyrTyr-377 456-ArgLeuLysGluLeu-460 Antigenic Index - Jameson-Wolf l-MetAlaGluAlaThrAsp-6 24-LysGluLeuGluProSerTrp-30 36-GluArgLeuGluAspValAlaLeuGluSerSerAsnAlaTrpAsnAsnAlaGlyThrGly-55 97-AlaGluGlyLysLeuGluAspAsnSer-105 117-MetAsnGluAspHisCysSerTyrLeuGlnLysArgTyrAspAlaPheLysThrGlnLysLeuPheGlu-13 9 141-MetGluPheSerThrAspArgAsnLysIleSerAsp-152 157-MetMetArgGlyArgAspGluAsnGlnPro-166 169-AlaAsnTyrSerAlaGluGlyThrAspValAspPheGlyArgLeuThrArgGlnMet-187 191-LeuGlnGlyLysGlyValLysThrGluPheAsnArgHisValGluAspIleLysArgGluSerAspGly-21 3 219-ThrAlaAspThrArgAsnProAspGlyGlnLeu-229 249-GlnLysSerGlyIleProGluGlyLysGlyTyrGly-260 269-PheArgAsnSerAsnProGluThrAlaGluGlnHisAsn-281 300-LeuAspThrArgAsnValAspGlyLysArgHisLeu-311 322-AsnPheLeuLysGlnGlySerLeuMet-330 361-GluLeuArgLysThrLysGluGluArgPhe-370 377-TyrProGluAlaAsnProAspAspTrpGlu-386 395-GlnIleIleLysLysAspSerGluLysGlyGly-405 415-AlaHisAlaAspGlySer-420 428-SerProGlyAlaSerThr-433 446-PheProGluArgThrProSerTrpGluGlyArgLeuLysGluLeuValProGlyTyr-464 467-LysLeuAsnGluAsnProGluArgAlaAspGlu-477 Hydrophilic Regions - Hopp-Woods l-MetAlaGluAlaThrAsp-6 24-LysGluLeuGluPro-28 36-GluArgLeuGluAspValAlaLeuGluSer-45 97-AlaGluGlyLysLeuGluAspAsnSer-105 117-MetAsnGluAspHisCys-122 125-LeuGlnLysArgTyrAspAlaPheLysThr-134 141-MetGluPheΞerThrAspArgAsnLysIleSerAsp-152 158-MetArgGlyArgAspGluAsnGlnPro-166 172-SerAlaGluGlyThrAspValAspPhe-180 182-ArgLeuThrArgGlnMet-187 194-LysGlyValLysThrGluPheAsnArgHisValGluAspIleLysArgGluSerAspGly-213 219-ThrAlaAspThrArgAsnProAspGly-227 252-GlyIleProGluGlyLysGly-258 272-SerAsnProGluThrAlaGluGlnHisAsn-281 300-LeuAspThrArgAsnValAspGlyLysArg-309 361-GluLeuArgLysThrLysGluGluArgPhe-370 380-AlaAsnProAspAspTrpGlu-386 395-GlnIleIleLysLysAspSerGluLysGlyGly-405 446-PheProGluArgThrProSerTrpGluGlyArgLeuLysGluLeuVal-461 467-LysLeuAsnGluAsnProGluArgAlaAspGlu-477 a205-l AMPHI Regions - AMPHI 6-ProGluGlnAsnValValArgLeuThrGlyLysHisProAsnAspLeuGluAlaValValGlyLys-27 46-CysHisThrLeuPheAlaLysLeuValGlyAsnIleAlaGluAspGlyGlyLys-63 75-GlnProTyrGlnAla-79 Antigenic Index - Jameson-Wolf 1-ProLeuLysGlyLeuProGluGlnAsnVal-lO 13-LeuThrGlyLysHisProAsnAspLeuGluAlaValVal-25 27-LysCysMetGluThrAspGlyLysGlyAlaProSerGly-39 57-IleAlaGluAspGlyGlyLysLeuThr-65 77-TyrGlnAlaGlyLysSerGlyTyr-84 96-IleAspSerGluGly-100 103-TyrPheArgArgArgHisTyr-109 Hydrophilic Regions - Hopp-Woods 13-LeuThrGlyLysHisProAsnAspLeuGluAlaValVal-25 27-LysCysMetGluThrAspGlyLysGlyAla-36 57-IleAlaGluAspGlyGlyLysLeu-64 78-GlnAlaGlyLysSerGly-83 96-IleAspSerGluGly-100 104-PheArgArgArgHisTyr-109 a206 AMPHI Regions - AMPHI 32-ProLysGlnThrValArgGlnIleGlnAlaVal-42 44-IleSerHisIleAspArgThrGlnGly-52 81-CysSerGlyMetIleGln-86 99-ArgThrAlaArgAspMet-104 150-SerGlyLysThrIleLysThrGlu-157 Antigenic Index - Jameson-Wolf 2-PheProProAspLysThrLeu-8 21-GlyThrThrSerGlyLysHisArgGlnProLysProLysGlnThrValArg-37 45-SerHisIleAspArgThrGlnGlySerGln-54 66-ThrProTyrLysTrpGlyGlySerSerThr-75 96-LysLeuProArgThrAlaArgAspMetAlaAlaAlaSerArgLys11eProAspSerArgLeuLysAlaGly- 119 126-ThrGlyGlyAlaHisArgTyrSer-133 148-ProSerSerGlyLysThrIleLysThrGluLysLeuSer-160 Hydrophilic Regions - Hopp-Woods 23-ThrSerGlyLysHisArgGlnProLysProLysGlnThrVal-36 45-SerHisIleAspArgThrGlnGlySerGln-54 96-LysLeuProArgThrAlaArgAspMetAlaAlaAlaSerArgLysIleProAspSerArgLeuLysAlaGly- 119 149-SerSerGlyLysThrIleLysThrGluLysLeuSer-160 a211 AMPHI Regions - AMPHI 18-ValGlyAsnGlyValAspGluPheGlyArgGlyAla-29 57-GlnPheGluArgAla-61 98-IleGluGlyPheAspLysIleAsnProAla-107 Antigenic Index - Jameson-Wolf 8-AsnGlnLeuGlyGlyArgAsnGlyThrAlaValGlyAsnGlyValAspGluPheGlyArgGlyAlaAspAsnGl nValGluPheLeuGlu-37 44-GlyAlaSerGlyArgAlaAla-50 73-GlyGluAspAspValVal-78 100-GlyPheAspLysIleAsnProAlaVal-108 141-ArgTyrHisProLysLeuHisAspGlyAsnGlnAsnGlyLysArgHisGlyLysLeuHisHisArgAla-16 3 169-CysGlnSerAlaGly-173 Hydrophilic Regions - Hopp-Woods 10-LeuGlyGlyArgAsnGlyThr-16 21-GlyValAspGluPheGlyArgGlyAlaAspAsnGlnValGluPheLeuGlu-37 73-GlyGluAspAspValVal-78 100-GlyPheAspLysIleAsn-105 142-TyrHisProLysLeuHisAspGlyAsnGlnAsnGlyLysArgHisGlyLysLeuHisHis-161 a212 AMPHI Regions - AMPHI 6-TrpAsnGlyIleProAspIleArgThr-14 16-AspGlnThrIleArgLysHisAlaHis-24 40-PheGlnThrAlaGlnAsp-45 63-CysLeuGlnPheAspSerIleAsnLeuIleGluHisIle-75 89-ThrArgArgLeuHisGluHis-95 199-ArgLeuLeuGlyHis-203 238-HisAsnHisLeuTyrArgSerIleThrGlnAlaGluAlaGluLysIle-253 262-TyrAlaGluProLeuCysGlyLeu-269 397-TrpAsnGluAlaGluGluAla-403 439-AspSerProAspHis-443 445-ProLeuValGlyAlaLeuGlyAspIleAlaAlaMetGlnGlnThr-459 481-AlaTyrAlaAsnThrAlaHisGlyThrArgGlyLeu-492 506-IleLeuGlyLeuPro-510 512-ProLeuSerLysArgLeuArg-518 Antigenic Index - Jameson-WoIf 10-ProAspIleArgThrLeuAspGlnThrIleArgLysHisAlaHisProLeu-26 33-ProAspAsnGlnIleProAsnPhe-40 42-ThrAlaGlnAspAlaSerAspAlaGluCysArgLeuLysHisArgLeuAspGln-59 85-ProProSerArgThrArgArgLeuHisGlu-94 105-AlaIleProGlnThrGluSerLysProAspLysProTrp-117 120-LeuProGlnThrSerGluArgGlnLysProGluHis-131 158-LeuGluAlaArgLysAlaAlaGln-165 168-SerGlyAsnArgGlnGly-173 178-LysIleSerProHisAspThrGluGlnThrGlu-188 193-GlyTyrGlyTyrThrLys-198 205-LeuProGluSerGluThrTrpGlyGlyAsnGly-215 220-AsnTyrSerArgThrGluGlnGlnArgAsnHisGluLeuGlyLeu-234 236-LysHisHisAsnHisLeu-241 245-IleThrGlnAlaGluAlaGluLysIleAla-254 258-LeuAsnThrProTyrAla-263 294-LeuHisGluAspThrProLeu-300 302-AspIleSerHisAspGlyGluLysTrpIle-311 328-ThrGlyAlaAsnSerProTyrLeuPro-336 346-ArgGlnIleArgGlyGlnThrGlyLeuThrProSerThrProPheSerGluGlnLeuArg-365 376-ProSerTrpHisGly-380 391-AsnSerSerHisThrGlyTrpAsnGluAlaGluGluAlaSerAsnArgGlnAla-408 424-AsnProAsnProGlnLysHisGlnGly-432 436-IleArgCysAspSerProAspHisLeuPro-445 464-AlaLeuAspLysAsnTyrArgIleAspAla-473 486-AlaHisGlyThrArgGlyLeuAla-493 511-HisProLeuSerLysArgLeuArgHis-519 522-HisProAsnArgAlaIle-527 531-1leValArgArgLysAspLeuThrPro-539 Hydrophilic Regions - Hopp-Woods 10-ProAspIleArgThrLeuAspGlnThrIleArgLysHisAla-23 44-GlnAspAlaSerAspAlaGluCysArgLeuLysHisArgLeuAspGln-59 87-SerArgThrArgArgLeuHisGlu-94 105-AlaIleProGlnThrGluSerLysProAspLys-115 122-GlnThrSerGluArgGlnLysProGluHis-131 158-LeuGluAlaArgLysAlaAlaGln-165 180-SerProHisAspThrGluGlnThrGlu-188 206-ProGluSerGluThr-210 222-SerArgThrGluGlnGlnArgAsnHisGlu-231 246-ThrGlnAlaGluAlaGluLysIleAla-254 294-LeuHisGluAspThrProLeu-300 303-IleSerHisAspGlyGluLysTrpIle-311 346-ArgGlnIleArgGly-350 398-AsnGluAlaGluGluAlaSerAsnArgGlnAla-408 426-AsnProGlnLysHisGlnGly-432 436-IleArgCysAspSerProAsp-442 467-LysAsnTyrArgIleAspAla-473 513-LeuSerLysArgLeuArgHis-519 531-IleValArgArgLysAspLeuThrPro-539 a214-l AMPHI Regions - AMPHI 6-CysLysLeuPheValLeuIle-12 69-ValThrArgGlyGlyLysGlyGlyGluSerVal-79 88-PheSerGlnThrLeuAsp-93 122-LysValGlnArgGlyGlyAspVal-129 150-ThrLysSerGlyAlaLysSerAlaSerLys-159 Antigenic Index - Jameson-Wolf 23-LeuGlnSerAspSerArgGlnProIle-31 33-IleGluAlaAspGlnGlySerLeuAspGlnAlaAsnGlnSerThrThrPheSerGlyAsn-52 71-ArgGlyGlyLysGlyGlyGluSerValArgAlaGluGlySerProValArgPheSerGlnThrLeuAspGlyG lyLysGlyThrValArgGlyGlnAlaAsnAsn-105 119-GlyAsnAlaLysValGlnArgGlyGlyAspValAlaGlu-131 137-TyrAsnThrLysThrGluVal-143 148-GlySerThrLysSerGlyAlaLysSerAlaSerLysSerGlyArgValSerVal-165 168-GlnProSerSerThrGlnLysSerGlu-176 Hydrophilic Regions - Hopp-Woods 25-SerAspSerArgGlnProIle-31 33-IleGluAlaAspGlnGlySerLeuAspGlnAlaAsn-44 71-ArgGlyGlyLysGlyGlyGluSerValArgAlaGluGlySerPro-85 92-LeuAspGlyGlyLysGlyThrValArgGlyGlnAla-103 121-AlaLysValGlnArgGlyGlyAspValAlaGlu-131 148-GlySerThrLysSerGlyAlaLysSerAlaSerLysSerGlyArg-162 171-SerThrGlnLysSerGlu-176 a215 AMPHI Regions - AMPHI 21-SerLeuSerAlaTrpLeuGlyArgIle-29 67-SerSerLysGlyAlaLysGlnPheProGlu-76 Antigenic Index - Jameson-Wolf 3 -ValArgTrpArgTyrGly-8 28-ArgIleSerGluValGluIleGluGluValArgLeuAsnProAspGluProGlnTyrThrMetAspGlyLeuA spGlyArgArgPheAspGluGlnGlyTyrLeuLys-63 65-HisLeuSerSerLysGlyAlaLysGlnPheProGluSerSerAspIleHisPheAspSerProHisLeu-87 99-ValGlySerAspGluAlaValTyrHisThrGluAsnLysGlnValLeuPhe-115 123-LysThrAlaAspGlyLysArgGlnAlaGlyLysValGluAlaGluLysLeuHisValAspThrGluSerGln TyrAlaGlnThrAspThrProVal-154 160-AlaSerHisGlyGlnAlaGlyGlyMetThrTyrAspHisLysThrGly-175 179-PheSerSerLysValLys-184 187-IleTyrAspThrLysAspMet-193 Hydrophilic Regions - Hopp-Woods 29-IleSerGluValGluIleGluGluValArgLeuAsnProAspGluProGlnTyr-46 49-AspGlyLeuAspGlyArgArgPheAspGlu-58 65-HisLeuSerSerLysGlyAlaLysGlnPheProGluSerSerAspIleHisPhe-82 99-ValGlySerAspGluAlaValTyr-106 108-ThrGluAsnLysGlnValLeu-114 123-LysThrAlaAspGlyLysArgGlnAlaGlyLysValGluAlaGluLysLeuHisValAspThrGluSerGln TyrAla-148 170-TyrAspHisLysThr-174 187-IleTyrAspThrLysAspMet-193 a216 AMPHI Regions - AMPHI 21-AlaGluGlyLeuArgGluIleAlaAlaAspLeu-31 62-ArgLysMetAlaAla-66 167-LeuGlyAspAlaLeuAlaVal-173 203-ValAlaAspIleMetHis-208 218-LeuGlyThrProLeuLysGlu-224 244-GlyArgLeuLysGlyVal-249 253-GlyAspLeuArgArgLeuPheGlnGluCysAspAsnPheThrGlyLeuSerIle-270 274-MetHisThrHisProLysThrIleSerAla-283 292-LysValMetGlnAlaAsn-297 Antigenic Index - Jameson-Wolf 4-AlaGlyAsnGluLysTyrLeuAspTrpAlaArg-14 16-ValLeuHisThrGluAlaGluGlyLeuArgGluIleAlaAlaAspLeuAspGlu-33 45-CysLysGlyArgVal-49 53-GlyMetGlyLysSerGlyHisIleGlyArgLysMetAla-65 82-GluAlaAlaHisGlyAspLeu-88 92-ValAspAsnAspVal-96 101-SerAsnSerGlyGluSerAspGluIle-109 115-AlaLeuLysArgLysAspl1e-121 127-ThrAlaArgProAspSerThrMetAlaArgHisAlaAsp-139 146-ValSerLysGluAlaCysPro-152 179-ArgAlaPheThrProAspAspPheAla-187 190-HisProAlaGlySerLeuGlyLys-197 205-AspIleMetHisLysGlyGlyGlyLeuProAla-215 218-LeuGlyThrProLeuLysGluAlaIle-226 229-MetSerGluLysGlyLeu-234 239-ValThrAspGlyGlnGlyArgLeuLysGly-248 250-PheThrAspGlyAspLeuArgArgLeuPheGlnGluCysAspAsnPheThr-266 277-HisProLysThrIleSerAlaGluArgLeuAlaThrGluAlaLeuLys-292 305-ThrAspAlaAspGly-309 Hydrophilic Regions - Hopp-Woods 5-GlyAsnGluLysTyrLeuAspTrpAlaArg-14 16-ValLeuHisThrGluAlaGluGlyLeuArgGluIleAlaAlaAspLeuAspGlu-33 45-CysLysGlyArgVal-49 58-GlyHisIleGlyArgLysMetAla-65 102-AsnSerGlyGluSerAspGluIle-109 115-AlaLeuLysArgLysAspl1e-121 128-AlaArgProAspSerThrMetAlaArgHisAlaAsp-139 146-ValSerLysGluAlaCys-151 179-ArgAlaPheThrProAspAspPheAla-187 220-ThrProLeuLysGluAlaIle-226 229-MetSerGluLysGlyLeu-234 241-AspGlyGlnGlyArgLeuLys-247 253-GlyAspLeuArgArgLeuPheGlnGluCysAspAsn-264 279-LysThrIleSerAlaGluArgLeuAlaThrGluAlaLeuLys-292 305-ThrAspAlaAspGly-309 a218 AMPHI Regions - AMPHI 9-AlaLysValValSerThrMet-15 24-AlaMetAspGluIleHisSer-30 78-AlaArgSerTrpTrpArgAsnLeuHisGlyAlaPheGlyThrTrpValSerLeuIleLeu-97 lll-TrpGlyGlyLysPheValGlnAlaTrpSerGlnPhePro-123 176-AspGluProMetThrLeuGluThrValAspArgPheAlaArgXxxAsnArgPheGlnArgAlaLeuSerAla -199 Antigenic Index - Jameson-Wolf 13-SerThrMetProArgAsnGlnGlyTrp-21 35-GlySerThrGlyAsp-39 62-ValLysArgArgGlyIleLysAla-69 71-LeuLeuProProLysGlyArgAlaArgSerTrpTrp-82 86-HisGlyAlaPheGly-90 123-ProAlaGlyLysTrpGlyValGluProAsnProVal-134 143-ValLeuAsnAspGlyLysValLysGlu-151 167-ThrValGlyLysAspGlyIleAsnProAspGluProMetThr-180 182-GluThrValAspArgPheAlaArgXxxAsnArgPheGlnArg-195 201-PheAlaGlnArgArgGlyArgArgMetAspPhe-211 Hydrophilic Regions - Hopp-Woods 63-LysArgArgGlyIleLys-68 74-ProLysGlyArgAla-78 143-ValLeuAsnAspGlyLysValLysGlu-151 167-ThrValGlyLysAspGlyIleAsnProAspGluProMetThr-180 182-GluThrValAspArgPheAlaArgXxxAsnArgPheGlnArg-195 201-PheAlaGlnArgArgGlyArgArgMetAspPhe-211 a225-l AMPHI Regions - AMPHI 23-LeuAlaAspGluLeuThrAsn-29 37-IleLeuArgGlnPhe-41 155-AsnAlaMetGlyLeu-159 180-PheMetGlnHisIlePheLys-186 215-GlyAspMetValXxxPheArgThrLeuGlyGlySerArg-227 246-ThrGlyLysAsnIle-250 Antigenic Index - Jameson-Wolf 22-AlaLeuAlaAspGluLeuThr-28 32-SerSerArgGluGlnIleLeu-38 41-PheAlaGluAspGluGlnProVal-48 52-AsnArgXxxProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-66 71-GlyLeuAsnGluGlnProVal-77 81-AsnArgXxxProAlaArgArgAlaGlyAsnAlaAspXxx-93 100-GlyLeuAsnGluGlnProVal-106 llO-AsnArgValProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-124 129-GlyLeuAsnGluGlnProVal-135 137-ProValAsnArgAlaProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-153 173-ThrGlyPheAspCysSerGly-179 193-LeuProArgThrSerAlaGluGlnAlaArgMet-203 205-ThrProValAlaArgSerGluLeuGlnProGlyAspMetValXxx-219 222-ThrLeuGlyGlySerArgIle-228 242-HisAlaProArgThrGlyLysAsnIleGlu-251 254-SerLeuSerHisLysTyrTrpSerGlyLys-263 268-ArgArgValLysLysAsnAspProSerArgPhe-278 Hydrophilic Regions - Hopp-Woods 22-AlaLeuAlaAspGluLeuThr-28 32-ΞerSerArgGluGlnIleLeu-38 41-PheAlaGluAspGluGlnPro-47 53-ArgXxxProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-66 82-ArgXxxProAlaArgArgAlaGlyAsnAla-91 112-ValProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-124 140-ArgAlaProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-153 195-ArgThrSerAlaGluGlnAlaArgMet-203 207-ValAlaArgSerGluLeuGlnPro-214 245-ArgThrGlyLysAsnIleGlu-251 268-ArgArgValLysLysAsnAspProSerArg-277 a226 AMPHI Regions - AMPHI 44-LeuIleAlaTyrLeuLys-49 61-AlaAlaGlnPheIleAspPheTrpLeu-69 98-GlnLeuAlaGlySerValThrGlyIleValThr-108 141-ArgSerIleGlyGlyIleProAlaIleThr-150 157-AlaGlyLeuValGlyGlnIleAlaGlyTyrLys-167 197-GluArgSerArgArg-201 Antigenic Index - Jameson-Wolf 3-GluIleLeuArgGlnProSer-9 25-ValArgThrArgThrGlyAsnIle-32 81-TyrGlnAsnArgArgLysIle-87 117-GlyAlaGluArgGluVal-122 128-SerLysSerValThrAsn-133 139-IleThrArgSerIleGlyGly-145 167-LysMetLeuLysAsnThrVal-173 195-SerLeuGluArgSerArgArgMetAla-203 Hydrophilic Regions - Hopp-Woods 25-ValArgThr rgThr-29 82-GlnAsnArgArgLysIle-87 117-GlyAlaGluArgGluVal-122 195-SerLeuGluArgSerArgArgMetAla-203 a227 AMPHI Regions - AMPHI 36-GlyValLeuPheAlaLeuLeuGlnAla-44 52-LeuGlnGlnLeuThrAspAlaLeu-59 74-ValIleSerTyrLeuAspLeuIleAlaAspAspTrpPheSer-87 a228 AMPHI Regions - AMPHI 24-GluValLysGluAlaValGlnAlaValGlu-33 40-AlaAlaSerAlaAlaGluSerAlaAlaSerAlaValGluGluAlaLysAspGlnValLysAspAla-61 78-GluAlaValThrGluAlaAlaLysAspThrLeuAsnLysAlaAlaAspAlaThrGlnGluAlaAlaAspLysM etLysAspAlaAla-106 Antigenic Index - Jameson-Wolf 18-SerGlnGluAlaLysGlnGluValLysGluAlaValGln-30 32-ValGluSerAspValLysAspThrAlaAlaSerAlaAlaGluSerAlaAlaSerAlaValGluGluAlaLysA spGlnValLysAspAlaAlaAlaAspAlaLysAlaSerAlaGluGluAlaValThrGluAlaLysGluAlaValTh rGluAlaAlaLysAspThrLeuAsnLysAlaAlaAspAlaThrGlnGluAlaAlaAspLysMetLysAspAlaAla Lys-107 Hydrophilic Regions - Hopp-Woods 18-SerGlnGluAlaLysGlnGluValLysGluAlaValGln-30 32-ValGluSerAspValLysAspThrAlaAlaSerAlaAlaGluSerAlaAlaSerAlaValGluGluAlaLysA spGlnValLysAspAlaAlaAlaAspAlaLysAlaSerAlaGluGluAlaValThrGluAlaLysGluAlaValTh rGluAlaAlaLysAspThrLeuAsnLysAlaAlaAspAlaThrGlnGluAlaAlaAspLysMetLysAspAlaAla Lys-107 a230-l AMPHI Regions - AMPHI 6-GluLysTyrArgThr-10 49-AspHisSerIleAsnAsn-54 56-IleGlnAsnGluGln-60 73-GlnSerLeuLeuGln-77 81-LeuLysGlnGlyAlaLys-86 96-GlnIleLysGlnIleIle-101 133-PheValGluGluIleArgAspGlnPhe-141 144-GlnAsnLeuValAsnLeuVal-150 161-AlaGluGlnLeuIleArgLeuThrGlnValAsnArgThrIleArg-175 184-PheIleAlaGlnVal-188 194-AspLeuGlnLysPheTyrAsn-200 234-GluValLysAsnAlaPheGluGluArgValAlaArgLeu-246 272-ValAlaAspPheAsnLys-277 284-AspAspAlaPheAsnHisProSerSerLeuAlaGluAla-296 319-SerGlyMetProGluAsnLeuIleAsnAlaVal-329 398-LeuAsnGlyGlyLys-402 426-GluAlaTyrAlaGluLeu-431 444-ValArgLeuIleGlyLeuProAlaPro-452 456-GluValGlnAlaValThrProProAspAspIleAla-467 488-LeuLeuIleArgTyrPheAsn-494 Antigenic Index - Jameson-Wolf 4-SerIleGluLysTyrArgThrProAla-12 32-SerHisProGlyAlaAsp-37 42-ValGlyAspGluLysIleSerAspHisSerIle-52 56-11eGlnAsnGluGlnAlaAspGlyGlyGlyProSerArgAspAlaVal-71 80-TyrLeuLysGlnGlyAla-85 92-ValSerSerGluGlnIleLys-98 lOl-IleValAspAspProAsnPheHisAspAlaAsnGlyLysPheAsp-115 122-TyrLeuSerGlnArgHisMetSerGluAspGlnPheValGluGluIleArgAsp-139 169-GlnValAsnArgThrIleArgSerHisThrPheAsnProAspGluPhe-184 189-LysValSerGluAlaAspLeu-195 199-TyrAsnAlaAsnLysLysAspTyrLeu-207 223-AspPheAlaAspLysGlnThrValSerGluThrGluValLysAsnAlaPheGluGluArgValAlaArg-24 5 247-ProAlaAsnGluAlaLysProSerPheGluGlnGluLysAlaAlaValGluAsnGluLeuLysMetLysLys AlaValAlaAspPheAsnLysAlaLysGluLysLeuGlyAspAspAlaPheAsnHisProSerSerLeuAlaGluA laAlaLysAsnSerGlyLeuLysValGluThrGlnGluThrTrpLeuSerArgGlnAspAlaGlnMetSerGlyMe tProGluAsn-324 330-PheSerAspAspValLeuLysLysLysHisAsnSerGlu-342 355-ArgAlaLysGluValArgGluGluLysThrLeuPro-366 368-AlaGluAlaLysAspAlaValArg-375 377-AlaTyrIleArgThrGluAlaAlaLysLeuAlaGluAsnLysAlaLysAspValLeu-395 399-AsnGlyGlyLysAlaValAsp-405 417-GlnGlnAlaArgGlnSerMetProProGluAlaTyr-428 432-LeuLysAlaLysProAlaAsnGlyLysProAla-442 459-AlaValThrProProAspAspIleAla-467 476-AlaLeuAlaGlnGlnGlnSerAlaAsnThrPhe-486 493-PheAsnGlyLysIleLysGlnThrLysGlyAlaGlnSerValAspAsnGlyAspGlyGln-512 Hydrophilic Regions - Hopp-Woods 6-GluLysTyrArgThr-10 42-ValGlyAspGluLysIleSerAsp-49 56-IleGlnAsnGluGlnAlaAspGlyGlyGlyProSerArgAspAlaVal-71 92-ValSerSerGluGlnIleLys-98 101-IleValAspAspProAsnPhe-107 110-AlaAsnGlyLysPheAsp-115 126-ArgHisMetSerGluAspGlnPheValGluGluIleArgAsp-139 189-LysValSerGluAlaAspLeu-195 200-AsnAlaAsnLysLysAspTyrLeu-207 223-AspPheAlaAspLysGlnThrValSerGluThrGluValLysAsnAlaPheGluGluArgValAlaArg-24 5 247-ProAlaAsnGluAlaLysProSerPheGluGlnGluLysAlaAlaValGluAsnGluLeuLysMetLysLys AlaValAlaAspPheAsnLysAlaLysGluLysLeuGlyAspAspAlaPheAsn-288 292-SerLeuAlaGluAlaAlaLysAsnSerGlyLeuLysValGluThrGlnGlu-308 310-TrpLeuSerArgGlnAspAlaGlnMet-318 333-AspValLeuLysLysLysHisAsnSer-341 355-ArgAlaLysGluValArgGluGluLysThrLeuPro-366 368-AlaGluAlaLysAspAlaValArg-375 377-AlaTyrIleArgThrGluAlaAlaLysLeuAlaGluAsnLysAlaLysAspValLeu-395 417-GlnGlnAlaArgGlnSerMetPro-424 432-LeuLysAlaLysProAlaAsnGly-439 461-ThrProProAspAspIleAla-467 496-LysIleLysGlnThrLysGlyAlaGlnSerValAspAsnGlyAspGlyGln-512 a231-l AMPHI Regions - AMPHI 7-IleAsnArgProTyrGlnLysProAlaGluLeu-17 98-ArgIlePheSerPheProGln-104 209-AlaValAspAsnValLysGlyValAlaVal-218 228-AlaValAlaGlyPheArgArgCysSerAlaAla-238 263-LeuAlaAlaValProArgIleThrGln-271 281-LysProPheHisAspPhePheAsnLeu-289 Antigenic Index - Jameson-Wolf l-MetSerLysArgLysSerIleAsnArgProTyrGlnLysProAlaGlu-16 18-ProProLeuGlnAsnAsnProProPheTyrArgLysAsnArgArgLeuAsn-34 39-AlaAspGlyGlyCysAlaSerProGlnLysCysArgAlaArgGlyPheGln-55 90-ProAlaValArgProArgArgLeuArg-98 135-MetProArgArgProVal-140 150-PheAlaAspArgAsnLeuArg-156 166-GluHisAlaAspAlaAsp-171 174-AlaPheArgArgArgAlaGlnVal-181 183 -AlaArgThrArgAla-187 194-ArgArgValAspIleArgHisProAspPhe-203 211-AspAsnValLysGly-215 231-GlyPheArgArgCysSerAlaAlaGlyGlyArgValGlyThr-244 246-ValProCysArgAlaGluTyrValGluTyrGlyAsnArgArgProHisArgLeuAlaAla-265 269-IleThrGlnArgThrGlnLysArgGlnGlyAspGlyLysProPhe-283 294-MetProMetProSerGluHis-300 Hydrophilic Regions - Hopp-Woods l-MetSerLysArgLysSerIleAsn-8 10-ProTyrGlnLysProAlaGlu-16 26-PheTyrArgLysAsnArgArg-32 45-SerProGlnLysCysArgAlaArgGly-53 92-ValArgProArgArgLeuArg-98 136-ProArgArgProVal-140 150-PheAlaAspArgAsnLeuArg-156 166-GluHisAlaAspAlaAsp-171 174-AlaPheArgArgArgAlaGlnVal-181 183-AlaArgThrArgAla-187 194-ArgArgValAspIleArgHis-200 231-GlyPheArgArgCysSerAlaAlaGlyGlyArgValGlyThr-244 246-ValProCysArgAlaGluTyr-252 254-GluTyrGlyAsnArgArgProHisArg-262 269-IleThrGlnArgThrGlnLysArgGlnGlyAspGlyLysProPhe-283 a232 AMPHI Regions - AMPHI 23-GlnPheLeuGlyAlaPheAsnAspAsnVal-32 55-GlyGlnMetLeuAsn-59 74-SerLeuSerGlyGlnLeuGlyAsnLysPheAspLysAlaValLeuAlaArgTrpAlaLysValLeuGluMetI leIleMet-100 127-ThrLeuPheGlyProLeuLysTyr-134 160-AlaIleLeuPheGly-164 167-LeuGlyThrAlaValAlaGlyValProProTyrIleValGlyIleLeuVal-183 214-ValArgGlyThrLysSerLeuLeuArgGlu-223 251-LeuProThrPheThrGln-256 319-ArgPheGluGlyLeuAsn-324 340-AlaValMetThrLeuIleGlyPhePheGlyGlyPhePheSerValProLeuTyrThrTrpLeu-360 Antigenic Index - Jameson-Wolf 1-MetTyrAlaLysLysGlyGlyLeuGlyLeuValLysSerArgArgPhe-lβ 75-LeuSerGlyGlnLeuGlyAsnLysPheAspLys-85 139-AspTyrLeuAspAspLysGluLeuMetMet-148 200-ValProAlaLysAlaAlaAspThrGlnIle-209 215-ArgGlyThrLysSerLeuLeuArgGluThrValArgHisLysPro-229 258-HisLeuGlyGlyAsnAspAsnVal-265 286-LysPheSerArgGluArgLeuArg-293 316-HisGlyHisArgPheGluGly-322 363-AlaSerSerGluThrPheArgAlaArgAla-372 420-IleLysArgGluArgArgPheLeu-427 431-AlaIleArgLysLysPro-436 Hydrophilic Regions - Hopp-Woods 2-TyrAlaLysLysGlyGly-7 H-ValLysSerArgArgPhe-16 81-AsnLysPheAspLys-85 140-TyrLeuAspAspLysGluLeuMet-147 201-ProAlaLysAlaAlaAspThrGlnIle-209 215-ArgGlyThrLysSerLeuLeuArgGluThrValArgHis-227 286-LysPheSerArgGluArgLeuArg-293 318-HisArgPheGluGly-322 366-GluThrPheArgAlaArgAla-372 420-IleLysArgGluArgArgPheLeu-427 431-AlaIleArgLysLysPro-436 a233 AMPHI Regions - AMPHI 61-PheAlaAspLysValGlnThr-67 71-GlnValArgValTrpLysAsn-77 88-AsnGlyValAlaLysLeuLeuGluThr-96 119-AlaLeuThrArgLeuIleGluGlnAlaGlyAsnAla-130 139-ProValAlaAspThrLeuLysCysAlaAspGlyGlyAsn-151 180-AlaAlaGluAsnLeuAspGlyIleThrAsp-189 Antigenic Index - Jameson-Wolf l-MetLysArgLysAsnIle-6 16-AlaArgPheGlyAlaAspLysProLysGlnTyrValGluIleGlySerLysThrValLeu-35 43-GluArgHisGluAlaValAsp-49 56-SerProGluAspThrPheAlaAspLysValGln-66 75-TrpLysAsnGlyGlyGlnThrArgAlaGluThrValArgAsnGlyVal-90 100-AlaGluThrAspAsn-104 109-AspAlaAlaArgCys-113 115-LeuProSerGluAlaLeu-120 123-LeuIleGluGlnAlaGlyAsnAlaAlaGluGlyGly-134 142-AspThrLeuLysCysAlaAspGlyGlyAsnIle-152 155-ThrValGluArgThrSerLeu-161 182-GluAsnLeuAspGlyIleThrAspGluAlaSerAlaValGluLysLeuGlyIle-199 206-GlyAspAlaArgAsnLeuLysLeuThrGlnProGlnAspAlaTyr-220 Hydrophilic Regions - Hopp-Woods l-MetLysArgLysAsnIle-6 18-PheGlyAlaAspLysProLysGlnTyrVal-27 43-GluArgHisGluAlaValAsp-49 56-SerProGluAspThrPheAlaAspLysValGln-66 79-GlyGlnThrArgAlaGluThrValArg-87 100-AlaGluThrAspAsn-104 127-AlaGlyAsnAlaAlaGlu-132 142-AspThrLeuLysCysAlaAsp-148 182-GluAsnLeuAspGlyIleThrAspGluAlaSerAlaValGluLysLeuGlyIle-199 206-GlyAspAlaArgAsnLeuLys-212 a234-2 AMPHI Regions - AMPHI 26-ArgSerLeuGluValGluLysValAlaSer-35 68-AspArgLeuGlySerGln-73 83-GlnGlnThrAsnArgPheAsnValLeuAsnArgThrAsn-95 121-GlyAspValThrGluPhe-126 206-AlaValAsnSerLeuValGlnAlaValAsp-215 Antigenic Index - Jameson-Wolf 21-AlaThrGluSerSerArgSerLeuGluValGluLysValAlaSer-35 51-ThrPheAspAsnArgSerSerPhe-58 62-IlePheSerAspGlyGluAspArgLeuGlySerGlnAla-74 83-GlnGlnThrAsnArgPheAsnValLeuAsnArgThrAsn-95 99-LeuLysGlnGluSerGlyIleSerGlyLysAlaHisAsnLeuLysGlyAlaAspTyr-117 121-GlyAspValThrGluPheGlyArgArgAspValGlyAsp-133 140-LeuGlyArgGlyLysSerGlnIle-147 160-AsnThrSerGluIle-164 169-GlnGlyAlaGlyGlu-173 175-AlaLeuSerAsnArgGluIle-181 185-GlyGlyThrSerGlyTyrAspAlaThrLeuAsnGlyLysValLeu-199 214-ValAspAsnGlyAlaTrpGlnProAsnArg-223 Hydrophilic Regions - Hopp-Woods 21-AlaThrGluSerSerArgSerLeuGluValGluLysValAla-34 52-PheAspAsnArgSerSerPhe-58 62-IlePheSerAspGlyGluAspArgLeuGlySerGlnAla-74 99-LeuLysGlnGluSerGlyIleSerGlyLysAlaHisAsn-111 122-AspValThrGluPheGlyArgArgAspValGlyAsp-133 141-GlyArgGlyLysSer-145 176-LeuSerAsnArgGluIle-181 a235 AMPHI Regions - AMPHI 8-LeuAlaAlaValLeuAlaLeu-14 18-GlnValGlnLysAlaProAsp-24 86-LeuThrAsnAlaAlaAspIle-92 95-ValArgProGluLysLeuHisGlnIlePhe-104 120-SerTyrGlnIleLeuAspSerValThrThr-129 165-GlyAlaLeuValSerAlaValValAsnGlnIleAlaAsnSerLeuThr-180 187-SerLysThrAlaAlaTyrAsnLeuLeuSerProTyr-198 Antigenic Index - Jameson-Wolf 20-GlnLysAlaProAspPheAspTyrThrSerPheLysGluSerLysProAla-36 43-ProLeuAsnGluSerProAspValAsnGlyThr-53 62-AlaProLeuSerGlu-66 79-GluThrPheLysGlnAsnGlyLeuThrAsn-88 93-HisAlaValArgProGluLysLeu-100 131-SerAlaLysAlaArgLeuValAspSerArgAsnGlyLysGluLeuTrpSerGlySerAlaSerIleArgGlu GlySerAsnAsnSerAsnSer-161 178-SerLeuThrAspArgGlyTyrGlnValSerLysThrAla-190 202-GlyIleLeuLysGlyProArgPheValGluGluGlnProLys-215 Hydrophilic Regions - Hopp-Woods 20-GlnLysAlaProAspPheAsp-26 29-SerPheLysGluSerLysPro-35 44-LeuAsnGluSerProAspVal-50 93-HisAlaValArgProGluLysLeu-100 131-SerAlaLysAlaArgLeuValAspSerArgAsnGlyLysGluLeuTrp-146 150-AlaSerIleArgGluGlySerAsnAsnSer-159 179-LeuThrAspArgGlyTyrGln-185 207-ProArgPheValGluGluGlnProLys-215 a236 AMPHI Regions - AMPHI ll-LeuCysThrAlaPheAlaAspGlyPhe-19 107-PheAlaGlyPheAlaAspCysArgProPhe-116 145-AlaAspAspValProArgPhePheAlaGlyGlu-155 168-ArgAspValValGlnGlyGlyLeu-175 215-ValGluGlyIleThrArgIle-221 245-IleArgLeuLeuHisGlyIlePheAsnArgIleGluValAla-258 316-ValAlaAspGlyPheArgHisPhe-323 Antigenic Index - Jameson-Wolf 42-GlyPheSerGlyAsnGlyLysPhe-49 58-ArgHisGlnGlnSerLysAlaGln-65 77-PhePheArgArgGlyAsnPheGlyPheGlyLeuGlnGlyArgThrAspGlyPhe-94 98-GlnArgLeuAspGlyGlyGlyTyr-105 109-GlyPheAlaAspCysArgProPhe-116 126-ValAspGlyArgGluLeuValProSerMetGluLys-137 144-AlaAlaAspAspValPro-149 155-GluAlaGlnAsnArgCysAsnGlnGluAsnGlnAlaAlaArgAspValValGlnGlyGlyLeu-175 195-IleGluValGluArgAlaGlnValPheArgAlaGluArgAsnHis-209 213-GlyLysValGluGlyIleThrArg-220 222-LysIleThrGlyAsnAlaPheLeu-229 261-GlyLysGlnLysAlaGlnGly-267 292-IleGlyGlyCysArgProGlnAlaGlnAspValArgAla-304 310-PheLeuArgArgAspAspValAlaAspGly-319 Hydrophilic Regions - Hopp-Woods 89-GlyArgThrAspGly-93 98-GlnArgLeuAspGlyGlyGly-104 127-AspGlyArgGluLeuValProSerMetGluLys-137 144-AlaAlaAspAspValPro-149 156-AlaGlnAsnArgCysAsnGlnGluAsnGlnAlaAlaArgAspValVal-171 195-IleGluValGluArgAlaGlnValPheArgAlaGluArgAsnHis-209 214-LysValGluGlyIleThrArg-220 261-GlyLysGlnLysAlaGlnGly-267 295-CysArgProGlnAlaGlnAspValArgAla-304 311-LeuArgArgAspAspValAlaAspGly-319 a239 AMPHI Regions - AMPHI 49-PheArgLeuIleGlnSerCys-55 72-AsnAlaHisArgLysGln-77 123-ProGlyPheAsnAlaLeuProAlaIlePhe-132 165-SerSerAsnGluTrp-169 221-PheCysAlaThrIleCysAlaSerLeuArg-230 Antigenic Index - Jameson-Wolf 6-GlyIleAlaArgAsnArgArgMetGlu-14 19-CysArgArgProAspArgPheVa1ValArgGInThrArgLeuLeu-33 52-IleGlnSerCysGluValGluPro-59 66-HisAsnGlyLysSerGlyAsnAlaHisArgLysGlnGlnLysGluIle-81 100-ProAlaValArgSerAlaThrArgLysThrAla-110 132-PheArgGlyGlySerGlyLysSerAlaSer-141 144-AlaAlaGlnArgGlyArgGlyAlaCys-152 164-ArgSerSerAsnGluTrpLys-170 173-ThrAlaLysArgProProSerPheArgArgHisMetThrCysGlyAsnThrAlaProThrSerSerSerSer ArgLeuIleLys-200 209-ValAlaGlySerCysProArgSerArgValArgThr-220 248-TrpArgLeuAsnArgSerSerPro-255 Hydrophilic Regions - Hopp-Woods 6-GlyIleAlaArgAsnArgArgMetGlul4 20-ArgArgProAspArgPheValValArgGlnThrArg-31 67-AsnGlyLysSerGlyAsnAlaHisArgLysGlnGlnLysGluIle-81 102-ValArgSerAlaThrArgLysThrAla-llO 135-GlySerGlyLysSerAlaSer-141 146-GlnArgGlyArgGlyAlaCys-152 165-SerSerAsnGluTrpLys-170 173-ThrAlaLysArgProProSerPheArgArgHisMet-184 193-SerSerSerSerArgLeuIleLys-200 211-GlySerCysProArgSerArgValArgThr-220 251-AsnArgSerSerPro-255 a240 AMPHI Regions - AMPHI 19-AlaAspValGlyArgPheLeuHis-26 63-IleGlnCysLeuArgAsnHis-69 87-AlaProLeuPheAlaValCysPro-94 107-GlnGlyGluAspPheProArgAlaGlyIleGlnAsnHis-119 154-ValPheArgGlyPheIleAlaArgGlyValGlnAlaValHisAsn-168 188-PheLysArgLysPheGln-193 Antigenic Index - Jameson-Wolf 9-GlyThrGluThrArgArgGlnPheAla-17 39-IleAlaHisGlyArgArgSerAspPheIleArg-49 67-ArgAsnHisLysArgPheAspCysArgThrGlyPheAsp-79 lOl-ValGlyGlyArgIleGlyGlnGlyGluAspPheProArgAlaGlyIleGlnAsnHisHisArgSerGly-12 3 139-GlnGlyLeuAsnProLeuIleGluGlyLysAspAspVal-151 173-ValProGlnAsnAspPheArg-179 187-ValPheLysArgLysPhe-192 201-AsnIleGlyLysSerAspAspValCysLys-210 Hydrophilic Regions - Hopp-Woods 10-ThrGluThrArgArgGlnPheAla-17 41-HisGlyArgArgSerAspPheIleArg-49 67-ArgAsnHisLysArgPheAspCys-74 105-IleGlyGlnGlyGluAspPheProArg-113 145-IleGluGlyLysAspAspVal-151 187-ValPheLysArgLysPhe-192 203-GlyLysSerAspAspValCysLys-210 a241-l AMPHI Regions - AMPHI 6-ThrArgAlaAlaLysHis-ll 35-ThrHisThrProHisGluProAlaSerSer-44 71-LysMetProSerGluMetGluGlnThrLeu-80 109-PheLeuIleGlyCysIleAlaHisThrPheAsnArgSerLeuLys-123 126-PheHisAlaCysGlnArgMetValAlaVal-135 195-HisIleAspArgIleAlaGlyIleLeuThrValGln-206 22 ' 9-PheValGlnLysLeuIleValGlyIleIleHis-239 Antigenic Index - Jameson-Wolf l-MetProThrArgProThrArgAlaAlaLysHisProThrProProThrTrp-17 23-CysProArgProProTyrArgProProSerValGlnThrHisThrProHisGluProAlaSerSerThrCysA laAlaLysSerAlaAsnArgArgGluAsnPheHis-58 68-ProSerAsnLysMetProSerGluMetGluGlnThrLeuPheArgArgHisGlnIleProProSerCysArgG lnSer-93 119-AsnArgSerLeuLysAlaAspPhe-126 147-ThrIleAspAspAsnIleAla-153 166-PheAspPheAsnArgGluHisAlaArg-174 176-PheAsnThrAspGlnLeul81 188-ArgIleValGlyArgLysArgHisIleAspArgIleAla-200 209-PheHisGlnArgGluAsnAla-215 244-ArgAsnHisGlyIle-248 251-AspSerHisIleCysProPheArgAsnSerArgLeuIle-263 Hydrophilic Regions - Hopp-Woods l-MetProThrArgProThrArgAlaAlaLysHisProThr-13 37-ThrProHisGluProAlaSer-43 46-CysAlaAlaLysSerAlaAsnArgArgGluAsnPheHis-58 70-AsnLysMetProSerGluMetGluGlnThrLeuPheArg-82 120-ArgSerLeuLysAlaAspPhe-126 166-PheAspPheAsnArgGluHisAlaArg-174 188-ArgIleValGlyArgLysArgHisIleAspArgIleAla-200 209-PheHisGlnArgGluAsnAla-215 a242 AMPHI Regions - AMPHI 23-ProGluValAlaXxxGlnPheValAspPheValGlu-34 43-GlyPheCysHisIleLeuGlnAsnLeuThrGly-53 122-AsnProPhePheAspPhePheGlnAlaValVal-132 137-HisGlnSerGlyPheGlyAspValPhe-145 156-PheGluGlnGlyVal-160 191-PheGlyHisThrArgLeuPheAspIleCys-200 262-HisProPheAlaAspPheGlyAsnPheGlnAsnLeuLeuAlaLeu-276 Antigenic Index - Jameson-Wolf 13-HisPheGluGlnArgAlaGlyGlyIleAla-22 52-ThrGlyHisGlyAla-56 75-SerHisAlaAspIlePheProProArgCysPheGlyAspGlyPheAlaGlnArgGlyPhe-94 98-TrpArgAlaAspGlnAlaGlnAsnArgAla-107 137-HisGlnSerGlyPhe-141 152-LeuProArgGlnPheGluGlnGlyVal-160 164-AlaTyrAspGlyGlyPheGlyArgHisArgArgHisHis-176 283-MetArgCysAspArglleGly-289 Hydrophilic Regions - Hopp-Woods 13-HisPheGluGlnArgAlaGlyGlyIle-21 98-TrpArgAlaAspGlnAlaGlnAsnArgAla-107 155-GlnPheGluGlnGlyVal-160 168-GlyPheGlyArgHisArgArgHisHis-176 283-MetArgCysAspArgIleGly-289 a243 AMPHI Regions - AMPHI 25-IlePheSerMetLeu-29 35-IleThrArgLeuAlaArgLysAlaValGlnArgLeuThrAlaSerHisIleGlnArgPheLeu-55 80-AspSerSerArgIleThrSerThrIleSerSer-90 Antigenic Index - Jameson-Wolf 29-LeuProSerAsnAlaPro-34 37-ArgLeuAlaArgLysAlaValGln-44 55-LeuThrGluSerLysThrGlyAlaAsnLysSerSerSerSerCysLysPro-71 77-SerAlaSerAspSerSerArgIle-84 102-SerThrThrGlyAlaValThrLysSer-llO Hydrophilic Regions - Hopp-Woods 37-ArgLeuAlaArgLysAlaValGln-44 55-LeuThrGluSerLysThrGlyAlaAsnLysSerSerSerSerCysLys-70 78-AlaSerAspSerSerArgIle-84 a244-l AMPHI Regions - AMPHI 13-IleAlaAlaLeuLeuArg-18 24-AsnAlaLeuGlnGluIleAsnGlnIleIleProGlnThr-36 72-PheAlaCysHisArgLeuHisArgLeu-80 102-LysCysPheLeuGlnLeuValGln-109 lll-HisLeuHisAlaHis-115 189-IleSerArgLeuCysGlySerLeuPhe-197 206-CysLeuAspGlyPheHisArgLeuHis-214 217-AsnArgPhePheThr-221 245-TyrProArgLys11eArgThrPheSerArgAsnPheLysGlnArg-259 Antigenic Index - Jameson-Wolf l-MetProSerGluAlaArgGlnAlaGlySerAspGly-12 20-ValTyrThrGlnAsnAla-25 35-GlnThrProSerGly-39 44-HisArgAsnHisSerArgAlaGlnHis-52 81-MetAspIleArgIle-85 91-PheArgIleAspPheLeuAsp-97 125-IleGlnLysArgHis-129 134-LeuAspArgGlnHisPheHisGlyLysLeuLeuSerGlyGluLeuValArg-150 179-GlnLeuGlyAsnProArgLeu-185 234-LeuLysThrAsnTrpLysSerLysSerSerTyrTyrProArgLysIleArgThrPheSerArgAsnPheLys GlnArgGlnArgIleSerAsnSerPheSerAsnProLeuProLysLys-273 Hydrophilic Regions - Hopp-Woods l-MetProSerGluAlaArgGlnAlaGlySerAspGly-12 46-AsnHisSerArgAlaGlnHis-52 81-MetAspIleArgIle-85 91-PheArgl1eAspPheLeuAsp-97 236-ThrAsnTrpLysSerLysSer-242 247-ArgLysIleArgThrPheSerArgAsnPheLysGlnArgGlnArgIle-262 a246-2 AMPHI Regions - AMPHI 39-AlaValAsnIleAlaGlnCysPheThr-47 60-ArgCysAlaGluValLeuValGluGlnPheAlaAsnLeuPhePhe-74 83-AspMetGlyArgPhe-87 132-PheGlyCysAspAspValValAspAspPheAlaGlyPheGlyArgCysPheArgProVal-151 156-GlnLeuGlyGlnValPhePheGln-163 Antigenic Index - Jameson-Wolf l-MetHisGlyArgAsnGlyGlyThrGln-9 18-GlnThrGlnArgThrCysPheSerAsnGlyGluValHisAlaThrGlnThrAspIleGlySer-38 78-AspCysGlyHisHisAspMetGlyArg-86 92-LeuAspAspGluLeuAla-97 133-GlyCysAspAspValValAspAspPheAlaGlyPheGlyArgCysPheArg-149 166-GlnGlnGlyArgGlnPheArgGln-173 Hydrophilic Regions - Hopp-Woods l-MetHisGlyArgAsnGlyGly-7 92-LeuAspAspGluLeuAla-97 136-AspValValAspAsp-140 169-ArgGlnPheArgGln-173 a247-l AMPHI Regions - AMPHI 44-ValValSerSerCysSerLysIleAlaLysProGlyLysLysIleSerThrLeuGlnGlu-63 153-PheAspSerSerThr-157 Antigenic Index - Jameson-Wolf ll-GluSerThrAspIleLysTyrProGly-19 33-IleAspAspLeuAspAlaSerAla-40 47-SerCysSerLysIleAlaLysProGlyLysLysIleSerThrLeuGlnGluAlaLysSer-66 70-1leThrAsnAspAspLysGlnAsnGlyAsnl1eThrArgGlnArgHis-85 95-IleAlaGlyGluGluGlyLeu-101 104-PheGlnLeuAspAspLysGlyLysTrpGlyAsn-114 120-LysLysIleArgHisMetLys-126 133-SerAspCysProGluAspAspAspAlaGlyLysGluGluLysPheLysTyrThrGlyThrPheAspSerSer ThrAsnAla-159 171-SerGlyThrAspThrLysIleAlaAlaSerSerAspAsnHis-184 192-AlaThrIleArgGlyGlyAsnValCysAlaAsnArgThrLeu-205 Hydrophilic Regions - Hopp-Woods ll-GluSerThrAspIleLys-16 33-IleAspAspLeuAspAlaSerAla-40 49-ΞerLysIleAlaLysProGlyLysLysIleSerThr-60 62-GlnGluAlaLysSer-66 71-ThrAsnAspAspLysGlnAsnGlyAsnIleThrArgGlnArgHis-85 95-IleAlaGlyGluGluGlyLeu-101 105-GlnLeuAspAspLysGlyLysTrpGly-113 120-LysLysIleArgHisMetLys-126 134-AspCysProGluAspAspAspAlaGlyLysGluGluLysPheLysTyr-149 153-PheAspSerSerThr-157 172-GlyThrAspThrLysIleAlaAlaSerSerAsp-182 a248-l AMPHI Regions - AMPHI 88-GluAsnCysGlyLysGlyLeu-94 121-ValGluAlaValLysArg-126 148-ThrGlnSerValSerLysMetProArgTyrIleIleGlu-160 168-GluAsnValTyrArgValThrAlaLysAlaTrpGlyLysAsn-181 Antigenic Index - Jameson-Wolf l-MetArgLysGlnAsnThrLeuThr-8 ll-ProThrSerAspGlyGlnArgGly-18 40-GlnSerTyrAsnThrGluGlnArgIleSerAlaAsnGluSerAspArgLysLeuAla-58 64-AlaAlaLeuArgGluGlyGluLeuGln-72 76-LeuGluTyrAspThrAspSerLysValThrPheSerGluAsnCysGlyLysGlyLeu-94 99-AsnValArgThrAsnAsnAspAsnGluGluAlaPhe-110 116-GlnGlyLysProThrValGluAlaValLysArgSerCysThrAlaLysSerThrGlyLeu-135 137-IleAspAsnLysGlyMetGluTyrLysLysGlyThrGlnSerValSerLysMetProArgTyr-157 162-LeuGlyValLysAsnGlyGluAsnValTyr-171 177-AlaTrpGlyLysAsnAlaAsnThr-184 192-ValSerAsnAsnAspGlu-197 Hydrophilic Regions - Hopp-Woods l-MetArgLysGlnAsnThr-6 ll-ProThrSerAspGlyGlnArg-17 42-TyrAsnThrGluGlnArgIleSerAlaAsnGluSerAspArgLysLeuAla-58 64-AlaAlaLeuArgGluGlyGluLeuGln-72 76-LeuGluTyrAspThrAspSerLysValThrPhe-86 101-ArgThrAsnAsnAspAsnGluGluAlaPhe-110 119-ProThrValGluAlaValLysArgSerCysThrAlaLysSer-132 137-IleAspAsnLysGlyMetGluTyrLysLysGlyThrGlnSerValSerLysMetPro-155 165-LysAsnGlyGluAsnValTyr-171 193-SerAsnAsnAspGlu-197 a249-l AMPHI Regions - AMPHI 6-CysPheArgLeuLys-10 15-GlyMetAlaLeuIleGluValLeuVal-23 42-ThrValAlaSerValArgGluAla-49 53-ThrIleValSerGlnIleThrGlnAsnLeuMetGluGlyMet-66 Antigenic Index - Jameson-Wolf l-MetLysAsnAsnAspCysPheArgLeuLysAsnProGlnSerGly-15 44-AlaSerValArgGluAlaGluThr-51 70-ProThrIleAspSerAspSerAsnLysLysAsnTyr-81 94-ValAspGlyAspPheGln-99 102-AlaIleLysThrLysThrGlnLeuAla-llO 135-ValCysLysAspSerSerGlyValAla-143 154-SerAsnCysAspGlySerAlaAsnGlyAspThrLeu-165 173-AspSerAlaGlyAspSerAspIleAlaArgThrAsnLeuGluThrAsnGlyAsnAsn-191 198-AlaArgValGlyGlyArgGlu-204 Hydrophilic Regions - Hopp-Woods 1-MetLysAsnAsnAspCysPheArgLeuLysAsnProGln-13 44-AlaSerValArgGluAlaGluThr-51 72-1leAspSerAspSerAsnLysLysAsn-80 94-ValAspGlyAspPheGln-99 102-AlaIleLysThrLysThrGlnLeuAla-110 135-ValCysLysAspSerSerGly-141 155-AsnCysAspGlySerAlaAsnGly-162 174-SerAlaGlyAspΞerAspl1eAlaArgThrAsnLeuGluThrAsnGly-189 200-ValGlyGlyArgGlu-204 a250 AMPHI Regions - AMPHI 8-ArgAsnGluPheIleArgGlyIleLysGlu-17 54-PheAlaGlyGlySerGlu-59 61-AlaThrValAsnLeuTrpAlaGluPro-69 Antigenic Index - Jameson-Wolf 5-SerSerProArgAsnGluPheIleArgGlyIleLysGluSerSer-19 34-MetGlnGlyGlyGlnLysGlyMetSer-42 54-PheAlaGlyGlySerGlu-59 90-GlyXxxGlyThrCysProAlaProGluArgAsnThrAlaGluLysSerArgAlaArg-108 Hydrophilic Regions - Hopp-Woods 5-SerSerProArgAsnGluPheIleArgGlyIleLysGluSerSer-19 95-ProAlaProGluArgAsnThrAlaGluLysSerArgAlaArg-108 a251 AMPHI Regions - AMPHI 47-GlnAlaAlaAspLeuProArgAsnHisIleSerProAlaTyr-60 81-ArgArgIleGlyAla-85 110-GlnValValAlaAspPheGlyGlyIleGluGlyPhe-121 156-ArgThrValGlyArgThrValArgLeuLeuLysMetIle-168 211-AlaArgThrValPheArgAlaHis-218 255-LeuGlyGlnGluCysArg-260 262-ArgHisIleAlaArgValGluSerLeuLeuArgValPheGluTyrAlaAlaAsp-279 Antigenic Index - Jameson-Wolf 9-GlnProArgAlaAspIleArgProProAlaGlnThrAspIleValProAsnCys-26 34-AspAlaAlaArgArgAlaValArg-41 50-AspLeuProArgAsnHisIleSer-57 74-GlyGlyPheArgGlyArgPheArgArg-82 98-IleArgValLysAlaValLysThrGluIle-107 145-ArgLeuValGlyThr-149 157-ThrValGlyArgThrValArg-163 175-ProValValArgGluAlaGly-181 208-ValLysHisAlaArgThrValPhe-215 251-IleLysAsnArgLeuGlyGlnGluCysArgAsnArgHisIleAlaArgValGluSer-269 286-LysThrLysThrArgAlaGluGlnProArgSerAla-297 Hydrophilic Regions - Hopp-Woods 10-ProArgAlaAspIleArgProProAlaGln-19 34-AspAlaAlaArgArgAlaValArg-41 76-PheArgGlyArgPheArgArg-82 98-IleArgValLysAlaValLysThrGluIle-107 157-ThrValGlyArgThrValArg-163 175-ProValValArgGluAlaGly-181 208-ValLysHisAlaArgThrValPhe-215 253-AsnArgLeuGlyGlnGluCysArgAsnArgHisIleAlaArgValGluSer-269 287-ThrLysThrArgAlaGluGlnProArg-295 a254 AMPHI Regions - AMPHI 6-ArgPheAsnThrTyrSerHis-12 32-GlyHisGlyAspGlyTyrArg-38 66-LysLeuLysSerIleLeuLys-72 142-ValLeuAlaValMetLysSerLeuThrAlaSer-152 Antigenic Index - Jameson-Wolf 2-TyrThrGlyGluArgPheAsnThrTyrSer-ll 32-GlyHisGlyAspGlyTyrArg-38 65-GlyLysLeuLysSerIleLeuLysLysThrAspHis-76 94-SerLeuArgAsnGlyProGly-100 120-ThrIleGlyArgLysSerGluLysArgLeuLeu-130 177-AsnAspGluLysIleArgHisGlyHisGly-186 Hydrophilic Regions - Hopp-Woods 65-GlyLysLeuLysSerIleLeuLysLysThrAspHis-76 120-ThrIleGlyArgLysSerGluLysArgLeuLeu-130 177-AsnAspGluLysIleArgHis-183 a255 AMPHI Regions - AMPHI 23-ValLysThrCysAlaAspPheHisAlaPheAspGlyValAspAlaHisHisGly-40 71-GlyIleGlnGlyPheAlaHis-77 139-AlaGlyGlyGlyPhe-143 Antigenic Index - Jameson-Wolf 40-GlyValGlyAspPheGly-45 54-AlaGlnAlaAspGlyAspValGlyGly-62 67-LeuArgAlaAspGlyIleGln-73 91-ValGlyGlyLysLysArgIleLeu-98 115-GlyAsnValGlyGlyAspPheArgAla-123 130-PhePheGlyAsnGlySerGlyGlyAsnAlaGly-140 145-GlyGlyThrProAla-149 Hydrophilic Regions - Hopp-Woods 56-AlaAspGlyAspVal-60 67-LeuArgAlaAspGly-71 92-GlyGlyLysLysArglleLeu-98 119-GlyAspPheArgAla-123 a256-l AMPHI Regions - AMPHI 90-GlyValValValHisPheArgSerCysGlyGlyValAla-102 127-ArgTyrArgGluIleTyrAlaVal-134 141-AsnAlaLeuAlaLysTyrLeuGlyGluGln-150 174-ArgPheAspSerGlyIleThrArgLeuLeu-183 197-ArgSerLeuGlnGlyPheGlnThrAla-205 207-AlaAlaGlyCysLysThrLeuGlyGluPheAspAspArgPheThrAlaProLeuHisGly-226 233-TyrTyrArgGlnThrSerCysLysProLeuLeuLysHisValAla-247 267-ProArgAlaAspGluValSer-273 Antigenic Index - Jameson-Wolf 4-ThrProProAspThrProPhe-10 12-LeuArgAsnGlyAsnAlaAspThrIleAla-21 24-PheLeuGlnArgSerAlaProAlaTyrArgArgGluLeuLeuProAspSerThrGlyLysThrLysThrAlaT yrAspPheSerAspGlyIleSerProAspAla-58 67-LeuGluGlyGlySerGlySer-73 82-AlaValArgAspArgGlyTrpAsn-89 97-SerCysGlyGlyValAlaAsn-103 112-GlyAspThrAlaGlu-116 124-LeuAlaAlaArgTyrArgGlu-130 147-LeuGlyGluGlnGlyGluAsnAlaLeu-155 166-ValAspAlaGluAlaAlaGlyAsnArgPheAspSerGlyIle-179 192-LeuIleProLysAlaArgSerLeuGln-200 212-ThrLeuGlyGluPheAspAspArgPheThr-221 227-PheAlaAspArgHisAspTyrTyrArgGlnThrSerCysLysProLeuLeu-243 259-ProPheLeuProProGluAlaLeuProArgAlaAspGluValSerGlu-274 292-SerThrGlyGlyArgLeu-297 311-AspSerPheArgThrAsnArgArg-318 Hydrophilic Regions - Hopp-Woods 28-SerAlaProAlaTyrArgArgGluLeuLeuPro-38 40-SerThrGlyLysThrLysThr-46 83-ValArgAspArgGlyTrp-88 124-LeuAlaAlaArgTyrArgGlu-130 147-LeuGlyGluGlnGlyGluAsnAlaLeu-155 166-ValAspAlaGluAlaAlaGlyAsnArgPheAspSerGlyIle-179 192-LeuIleProLysAlaArgSer-198 212-ThrLeuGlyGluPheAspAspArgPheThr-221 227-PheAlaAspArgHisAspTyrTyrArg-235 265-AlaLeuProArgAlaAspGluValSerGlu-274 313-PheArgThrAsnArgArg-318 a257 AMPHI Regions - AMPHI 24-SerPheLeuProAsn-28 73-AspLeuValAsnLysValLeuAlaGluValAlaArgLeuGluLysMetPhe-89 109-SerProProAlaAspPheLeuGluLeuLeuSerLeuAlaValIlePheThr-125 Antigenic Index - Jameson-Wolf 1-MetGlyArgHisPheGlyArgArgArgPhe-lO 31-AlaAlaAspAspGluLysArgAsnLysAspGluLysArgAsnGluAsn-46 56-GlySerGlyAlaGlu-60 65-GlyValAspAspArgArgAlaAlaAspLeuVal-75 83-AlaArgLeuGluLys-87 92-TyrArgGluAspSerLeuIleSerArgLeuAsnArgAspGlyTyrLeuThrSerProProAlaAspPhe-114 Hydrophilic Regions - Hopp-Woods 4-HisPheGlyArgArgArgPhe-10 31-AlaAlaAspAspGluLysArgAsnLysAspGluLysArgAsnGlu-45 65-GlyValAspAspArgArgAlaAlaAspLeuVal-75 83-AlaArgLeuGluLys-87 92-TyrArgGluAspSerLeuI1e-98 100-ArgLeuAsnArgAspGlyTyr-106 a259-l AMPHI Regions - AMPHI 154-TyrGlyArgValPheAlaAspIlePheGluLeuSer-165 172-AlaPheLysGlyMetLeuLysLeuThrAlaGluTyrLysAsnIlePheGlyAspAlaCysArg-192 203-AsnGlnAlaLeuGlnGluIleSerLysThrSerGlu-214 Antigenic Index - Jameson-Wolf 34-LysAlaTyrThrGluGluLeuProPro-42 61-SerAlaArgSerLysAlaLysAlaGluLysPheTyrArgGluLysMe IleGln-78 93-LeuGluHisLysPro-97 105-LysAsnHisGlyLysGlyMetAlaGluGlnValArgPheLysAla-119 121-ValLeuProAspAspGluAspAlaArgThrIleAla-132 144-GlyThrAspAlaValAlaSerGlyGluThrTyrGlyArgVal-157 168-LeuGluGlyArgAlaPhe-173 189-AspAlaCysArgSerGluThrAlaLeu-197 208-GluIleSerLysThrSerGluLysSerLysArg-218 Hydrophilic Regions - Hopp-Woods 35-AlaTyrThrGluGluLeuPro-41 62-AlaArgSerLysAlaLysAlaGluLysPheTyrArgGluLysMetIleGln-78 93-LeuGluHisLysPro-97 106-AsnHisGlyLysGlyMetAlaGluGlnValArgPheLysAla-119 121-ValLeuProAspAspGluAspAlaArgThrIleAla-132 168-LeuGluGlyArgAlaPhe-173 189-AspAlaCysArgSerGluThrAlaLeu-197 208-GluIleSerLysThrSerGluLysSerLysArg-218 a260 AMPHI Regions - AMPHI 12-ProPheSerSerLeuPheArgAlaLeuPhe-21 53-PheIleAspSerValGlyGlnValAlaAlaArgLeuPheGlnAlaPhe-68 154-ValGlnIleAsnGlnValGlyIleValAspLeuIlePro-166 176-AlaThrGlyCysThrGlyIleCysProLysCysProThrGlyCysArgPro-192 Antigenic Index - Jameson-Wolf 20-LeuPheGluAspArgValGlyIle-27 30-GlyAlaHisAspAlaAlaGlu-36 38-AspPheLeuProGluGluPheThrArg-46 80-ProAlaPheArgAlaArgGluGlnAlaArgArgGlySerGly-93 96-AlaGlyAsnAspLeuArgValProHisLysAspAlaValGluValAspIleAspGlyGlyAsnThrVal-ll. 126-ThrHisPheAspAspGlyAspAla-133 139-AlaGluAlaArgPhe-143 184-ProLysCysProThrGlyCysArgProVal-193 Hydrophilic Regions - Hopp-Woods 20-LeuPheGluAspArgValGlyIle-27 3 O-GlyAlaHisAspAlaAlaGlu-36 82-PheArgAlaArgGluGlnAlaArgArgGlySer-92 98-AsnAspLeuArgValProHisLysAspAlaValGluValAspIleAspGly-114 127-HisPheAspAspGlyAspAla-133 139-AlaGluAlaArgPhe-143 186-CysProThrGlyCysArgProVal-193 a261 AMPHI Regions - AMPHI 22-GlnIlePheArgGln-26 32-AspThrAlaArgAlaPheAlaAlaAla-40 50-GlyLeuLeuAlaAspIleVal-56 92-ValHisGlyPheAspLysHis-98 137-AlaValTyrLysGlyIleArgAsnAlaValPhe-147 158-GlnGlyIleValArgAsnLeu-164 203-AspValPheAlaProVal-208 212-CysLeuAsnGlnAlaGlyGly-218 Antigenic Index - Jameson-Wolf 40-AlaAlaAspAspAlaVal-45 60-HisPheValArgGlnArgProSerLeuArgLeu-70 74-HisGlnArgArgValAspLeu-80 86-ArgGlnIleLysGlyAsnValHisGlyPheAspLysHisVal-99 lll-AlaHisAlaArgAspAspValProTyr-119 126-AsnArgGlyIleGluGlnGluLysArgVal-135 149-SerPheAspGlyGlyGly-154 181-ArgAsnProAlaGly-185 197-LeuGluSerAsnGlyLeuAsp-203 214-AsnGlnAlaGlyGlyArgIleLeuThrAlaArgLysAspAspGlnGlyPhe-230 Hydrophilic Regions - Hopp-Woods 40-AlaAlaAspAspAlaVal-45 60-HisPheValArgGlnArgProSerLeu-68 74-HisGlnArgArgValAspLeu-80 94-GlyPheAspLysHisVal-99 112-HisAlaArgAspAspValPro-118 127-ArgGlyIleGluGlnGluLysArgVal-135 22l-LeuThrAlaArgLysAspAspGlnGly-229 a263 AMPHI Regions - AMPHI 32-AsnLeuIleGlyValLeuSerAsnAla-40 42-GluAlaLeuAlaPheTyrGlnGluValGlyLysLeuAsnAlaAlaAsnSerLeuThr-60 86-LysLeuAlaThrLeuLysLys-92 100-LysAlaAlaArgAlaLeuAlaAlaGlyGlu-109 115-LeuGlyAlaLeuAlaAlaPheThrGln-123 135-GluGluLeuLysAlaPhePheAspAla-143 157-ValAlaLeuAlaThrLeuCysAsnTyrValAsnAsnLeuGly-170 Antigenic Index - Jameson-Wolf 10-GluThrAlaProGluAlaAlaLysAlaArgValGluAla-22 37-LeuSerAsnAlaPro-41 72-AlaArgThrAsnGlnCysGly-78 97-GlnSerValLysAlaAlaArg-103 108-GlyGluPheAspAspAlaLysLeu-115 126-MetAlaLysLysGlyAlaValSerAspGluGluLeuLysAla-139 170-GlyGlnThrGluIleAsnProGluLeu-178 Hydrophilic Regions - Hopp-Woods ll-ThrAlaProGluAlaAlaLysAlaArgValGluAla-22 97-GlnSerValLysAlaAlaArg-103 108-GlyGluPheAspAspAlaLysLeu-115 126-MetAlaLysLysGlyAlaValSerAspGluGluLeuLysAla-139 a264 AMPHI Regions - AMPHI 55-ValAlaGluPheThrGlnThrGly-62 96-11eProSerTyrValArgValThrAsnThrLys-106 124-AsnArgIleIleAspValSer-130 183-LeuAsnGlnAlaAlaGlnAsnLeuAlaSerSer-193 Antigenic Index - Jameson-Wolf 27-AlaValValArgAlaGluLysLeuHisAlaSerAlaAsnArgSerTyrLysValAlaGlyLysArgTyrThrP roLysAsnGlnVal-55 57-GluPheThrGlnThrGlyAsnAlaSerTrp-66 68-GlyGlyArgPheHisGlyArgLysThrSerGlyGlyGluArgTyrAsp-83 103-ThrAsnThrLysAsnGlyLysSerVal-lll 114-ArgValAsnAspArgGlyProPheHisGlyAsnArgIleIleAspValSerLysAlaAlaAla-134 153-ValProGlyGlnSerAlaProValAlaGluAsnLysAspIlePheIle-168 170-LeuLysSerPheGlyThrGluHisGluAla-179 192-SerSerAlaSerAsnProAsnLeuSerValGluLysArgArgTyrGluTyr-208 216-AlaSerGlnGluArgAlaAlaGluAlaGluAlaGlnAla-228 Hydrophilic Regions - Hopp-Woods 27-AlaValValArgAlaGluLysLeuHisAlaSerAlaAsnArgSerTyrLysValAlaGlyLysArgTyrThrP ro-51 71-PheHisGlyArgLysThrSerGlyGlyGluArgTyrAsp-83 103-ThrAsnThrLysAsnGlyLys-109 115-ValAsnAspArgGlyProPheHis-122 125-ArgIleIleAspValSerLysAlaAlaAla-134 159-ProValAlaGluAsnLysAspIlePheIle-168 171-LysSerPheGlyThrGluHisGluAla-179 199-LeuSerValGluLysArgArgTyrGluTyr-208 216-AlaSerGlnGluArgAlaAlaGluAlaGluAlaGlnAla-228 a266 Antigenic Index - Jameson-Wolf 5-AsnAlaPheArgArgHisArgArgArgGlnCysProAsnArgLysProAlaMet-22 51-ProLeuLysArgLysHisPhe-57 80-SerArgAlaGlyAlaValHisAspGlnGlyTrpGlu-91 114-TrpHisThrArgAsnArgGlu-120 Hydrophilic Regions - Hopp-Woods 5-AsnAlaPheArgArgHisArgArgArgGlnCysProAsnArgLysProAlaMet-22 51-ProLeuLysArgLysHisPhe-57 80-SerArgAlaGlyAlaValHis-86 a268-l AMPHI Regions - AMPHI 6-AspGlyLeuHisLysPheLysHisIleCysSerAlaAla-18 22-IleLysGluProLeuAspLys-28 52-GlnGluValAspArgValSerGluTrp-60 70-GluPheGluGlnPheTrpLysGlyLeuProGlnThrValGlnAsn-84 89-SerGlnLysThrTrpLysSerGlyMetAspLys-99 110-GluThrProAsnGlyIleLys-116 Antigenic Index - Jameson-Wolf l-ValGlnSerArgTyrAspGly-7 21-LeuIleLysGluProLeuAspLysAlaLysGlnArgAsnGluGluLeuGluAlaAlaGluGluAlaAlaAla- 44 47-AlaLeuGlyArgGluGlnGluValAspArgValSerGluTrpGluGluArgTyrLysLeuSerArgSerGluP he-71 82-ValGlnAsnLysLeuGlnAlaSerGlnLysThrTrpLysSerGlyMetAspLysIleCysAlaAsnAsnAlaL ysAlaGluGlyGluThrProAsnGly-114 119-GluLeuAlaCysLysThrAlaGluThrGluAlaArgLeuGluGluLeuHisAsnArgLysLysAlaLeuLeu AspGluMetAlaArgGluAlaAspLysLysGluLeuProLysArgLeu-158 Hydrophilic Regions - Hopp-Woods 3-SerArgTyrAspGly-7 21-LeuIleLysGluProLeuAspLysAlaLysGlnArgAsnGluGluLeuGluAlaAlaGluGluAlaAlaAla- 44 47-AlaLeuGlyArgGluGlnGluValAspArgValSerGluTrpGluGluArgTyrLysLeuSerArgSerGluP he-71 91-LysThrTrpLysSerGlyMetAspLysIleCys-101 104-AsnAlaLysAlaGluGlyGluThrProAsn-113 119-GluLeuAlaCysLysThrAlaGluThrGluAlaArgLeuGluGluLeuHisAsnArgLysLysAlaLeuLeu AspGluMetAlaArgGluAlaAspLyΞLysGluLeuProLysArgLeu-158 a269 AMPHI Regions - AMPHI 54-TrpAspPheIleGlnAsnThr-60 73-PheLysThrArgAlaLeuGlyArgPheSerSerPro-84 Antigenic Index - Jameson-Wolf 42-ProAlaSerSerAla-46 60-ThrAlaSerProLysValSer-66 73-PheLysThrArgAlaLeuGlyArgPheSerSerPro-84 90-LeuSerGlyArgGlyValLysLysProLeu-99 107-GlnValAspThrSerAla-112 Hydrophilic Regions - Hopp-Woods 61-AlaSerProLysVal-65 73-PheLysThrArgAlaLeuGly-79 93-ArgGlyValLysLysProLeu-99 a270 AMPHI Regions - AMPHI 41-AspLeuThrGluGlyCys-46 49-ProAspGlySerArg-53 100-GlnProSerGlyThrTrp-105 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnArgLysLeu-7 41-AspLeuThrGluGlyCysThrLeuProAspGlySerArgValArgAlaAlaAlaValSerThrLysLysProP he-65 71-HisAlaProAlaGlyThrGlu-77 86-LysAsnMetAspMetGlyPhe-92 95-TyrMetPhGluArgGlnProSerGlyThr-104 116-ValGluGlyArgArgAspPheThrAla-124 128-IleGlySerArgThrPhe-133 Hydrophilic Regions - Hopp-Woods l-MetAsnLysAsnArgLysLeu-7 49-ProAspGlySerArgValArgAla-56 60-SerThrLysLysProPhe-65 73-ProAlaGlyThrGlu-77 96-MetPheGluArgGlnPro-101 116-ValGluGlyArgArgAspPheThrAla-124 a271-2 AMPHI Regions - AMPHI 6-MetAlaArgIleTrp-10 20-SerProCysProAla-24 29-ProLysSerLeuAlaLysCysAla-36 Antigenic Index - Jameson-Wolf 26-ThrThrLysProLysSerLeuAlaLys-34 41-ArgSerAsnCysLeu-45 60-CysSerSerThrThrGlyAlaProThrSerArg-70 78-SerAlaSerIleAsnLysAspThrArgMetProAlaSerVal-91 102-CysCysAlaAsnThrSerLysProProSer-lll Hydrophilic Regions - Hopp-Woods 27-ThrLysProLysSerLeuAla-33 80-SerIleAsnLysAspThrArgMet-87 105-AsnThrSerLysProPro-llO a272-2 AMPHI Regions - AMPHI 44-IleThrArgIleThrAspGlu-50 70-AlaGluGluPheSerSerThrAsn-77 106-PheArgAlaIleThrSer-lll 165-IleIleThrIleGluAspProIleGlu-173 194-AsnTrpMetAlaAlaLeuLysAsnThrLeuArgGlnAla-206 244-AsnGlnAlaLeuAspArgIleIleAsn-252 307-GlyAsnIleHisGluIleLysGluValMetLys-317 328-AspGlnHisLeuTyrGln-333 343-GlnAspAlaLeuLysAsnAlaAspSer-351 Antigenic Index - Jameson-Wolf 2-PheThrAspGluAsnMetThrAlaLysGluGluLeu-13 19-HisMetAsnLysAsnLysGlySerAsp-27 38-MetLysLeuAspGlyLysIleThrArgIleThrAspGluProLeuThrAlaGluLysCysMet-58 68-LysGlnAlaGluGluPheSerSerThrAsnGlu-78 85-LeuProAspThrSerArgPheArgVal-93 109-IleThrSerLysIleProLysPheGluSerLeuAsn-120 128-ValAlaLeuLysLysArgGly-134 142-ThrGlySerGlyLysSerThrSerLeu-150 154-IleAspTyrArgAsnGluAsnSerPheGly-163 168-IleGluAspProIle-172 176-HisGluHisLysAsnCys-181 184-ThrGlnArgGluValGlyValAspThrGluAsn-194 199-LeuLysAsnThrLeuArgGlnAlaProAsp-208 214-GluIleArgAspArgGluThrMet-221 241-AsnSerThrAsnGlnAlaLeuAspArg-249 254-PheProGluGluArgArgGluGlnLeuLeu-263 278-LeuValProArgAspGlyGlyLysGlyArgValAlaAla-290 310-HisGluIleLysGluValMetLysLysSerThr-320 336-GluLysGlyGluIleSerLeu-342 344-AspAlaLeuLysAsnAlaAspSerAlaHisAspLeu-355 361-LeuArgSerArgGlnAlaGlnSerSerGlyProAspLeuGluLeuLeu-376 Hydrophilic Regions - Hopp-Woods 2-PheThrAspGluAsnMetThrAlaLysGluGluLeu-13 20-MetAsnLysAsnLysGlySerAsp-27 38-MetLysLeuAspGlyLysIleThrArgIleThrAspGluProLeuThrAlaGluLysCysMet-58 68-LysGlnAlaGluGluPheSerSer-75 87-AspThrSerArgPheArgVal-93 112-LysIleProLysPheGluSer-118 128-ValAlaLeuLysLysArgGly-134 143-GlySerGlyLysSerThrSer-149 155-AspTyrArgAsnGluAsnSer-161 168-IleGluAspProIle-172 176-HisGluHisLysAsn-180 184-ThrGlnArgGluValGlyValAspThr-192 201-AsnThrLeuArgGlnAlaPro-207 214-GluIleArgAspArgGluThrMet-221 245-GlnAlaLeuAspArg-249 255-ProGluGluArgArgGluGlnLeuLeu-263 278-LeuValProArgAspGlyGlyLysGlyArgValAlaAla-290 310-HisGluIleLysGluValMetLysLysSerThr-320 336-GluLysGlyGluIleSerLeu-342 344-AspAlaLeuLysAsnAlaAspSerAlaHisAspLeu-355 361-LeuArgSerArgGlnAlaGlnSerSerGlyProAspLeuGluLeu-375 a274 AMPHI Regions - AMPHI 31-TyrLysAspGlyLys-35 lll-GluAlaValPheLysThrLeuSerPro-119 Antigenic Index - Jameson-Wolf 25-LeuValThrAspAspTyrTyrLysAspGlyLysHisIleAsp-38 40-GlnLeuHisArgAspGluGluAlaValArgArgHisIle-52 60-ProAspMetAsnAla-64 71-GlyGluPheAspGlyLysGlnPro-78 85-HisProThrArgLysAlaAspAspGlnThrVal-95 99-ProValGlySerAlaGlnAsnGlyArgAlaGluTyr-110 117-LeuSerProThrAsnHis-122 126-ArgValGluAspAlaAlaGly-132 136-ValGluAsnLysTrpIleThrSerGlnGlyAsnAlaValAspLeuThrProMetAspLysLeuPheAsnAsn ThrGluSerLys-163 Hydrophilic Regions - Hopp-Woods 29-AspTyrTyrLysAspGlyLysHis11eAsp-38 40-GlnLeuHisArgAspGluGluAlaValArgArgHisIle-52 72-GluPheAspGlyLysGln-77 86-ProThrArgLysAlaAspAspGlnThrVal-95 104-GlnAsnGlyArgAlaGluTyr-llO 126-ArgValGluAspAlaAlaGly-132 151-ThrProMetAspLysLeuPheAsn-158 a276 AMPHI Regions - AMPHI 9-MetMetArgSerAlaProSerMetValValArgArgTrpAlaThrMetMet-25 60-SerPheLysMetAlaArg-65 80-ProPheAspProMetGlyTrp-86 115-GlyArgLeuTyrArgThrPheSerAsn-123 164-ThrLysArgGlySerArgLeu-170 207-SerThrSerThrLeuArgLysLeuMetArgProSerThr-219 Antigenic Index - Jameson-Wolf 10-MetArgSerAlaProSerMetVal-17 29-PheSerIleArgArgSerSerAlaCysTrpThrArgArgSerAspSerLeuSer-46 52-SerSerAsnAsnAsnIle-57 67-Me AlaThrArgCysArgCysProProAspLysLeuLeuPro-80 82-AspProMetGlyTrp-86 88-SerProSerGlyAspAlaSerIleArg-96 103-TrpArgAlaAspArgThrSerAlaSerProAlaSerGlyArgLeuTyr-118 121-PheSerAsnArgValSerSerAsnArgAsnThrSerTrpGluThrArgAlaAsnTrpAlaArgArgGlnSer SerLeu-146 158-LeuProAlaAspGlySerThrLysArgGlySerArgLeuThrThr-172 176-ProLeuProGluArgProThrArgAlaThrArgSerProCysLeuMetSerArgLeuLysProSerArgAla LeuMetProSerGluArgTyrSerThrSerThrLeuArgLysLeuMetArgProSerThrArgCysGlyAla-223 229-CysSerGlyGlyValSerArgAsnAlaHisThrProSerAlaAlaArgAsn-245 Hydrophilic Regions - Hopp-Woods 29-PheSerIleArgArgSerSer-35 38-TrpThrArgArgSerAspSerLeu-45 67-MetAlaThrArgCysArgCysProProAspLys-77 90-SerGlyAspAlaSerIleArg-96 104-ArgAlaAspArgThrSerAla-llO 124-ArgValSerSerAsnArgAsnThrSerTrpGluThr-135 137-AlaAsnTrpAlaArgArgGlnSerSer-145 161-AspGlySerThrLysArgGlySerArg-169 176-ProLeuProGluArgProThrArgAlaThrArg-186 192-SerArgLeuLysProSerArg-198 200-LeuMetProSerGluArgTyrSer-207 210-ThrLeuArgLysLeuMetArgProSerThrArgCys-221 232-GlyValSerArgAsnAlaHis-238 a277 AMPHI Regions - AMPHI 43-PheGluValValGlyGlyLeuPheAspPheValLeu-54 70-CysProAsnGluValIleAspValPheHisAlaLeuGln-82 87-AlaPheAspAlaValGlyAspPheAlaGluTyrGlyGlyAlaValAspAlaAlaAspLeuLeuGluIleGlyG luLeuGlyTyrPheHis-116 180-AlaValGlyValValAlaValAla-187 Antigenic Index - Jameson-Wolf 2-ProArgPheGluAspLysLeuValGlyArgGlnGlyGluGlyGlyVal-17 69-PheCysProAsnGluVal-74 95-AlaGluTyrGlyGly-99 118-ValGluProAspPheProAlaGlnThrProArgAlaGluGlyGly-132 138-PheAspLysAlaAsp-142 162-AspIleGlyGlySerGlyLeuGluGlyAspLeu-172 196-LeuAspValGlyGlyLysProArgLeuGlyAla-206 208-CysAlaGlnThrGlyGlyGlyMetGly-216 219-GlyThrAspPheHis-223 226-GlyLeuAspAspGlyAla-231 239-LeuGlnPheGluAspAspLeuLeuGluGlyLysHisGlyLeu-252 Hydrophilic Regions - Hopp-Woods 2-ProArgPheGluAspLysLeuValGlyArgGlnGlyGlu-14 118-ValGluProAspPhe-122 126-ThrProArgAlaGluGly-131 138-PheAspLysAlaAsp-142 167-GlyLeuGluGlyAspLeu-172 198-ValGlyGlyLysProArgLeuGlyAla-206 226-GlyLeuAspAspGlyAla-231 239-LeuGlnPheGluAspAspLeuLeuGluGlyLysHisGlyLeu-252 a278 AMPHI Regions - AMPHI 7-GlyAlaIlePheSerIleGly-13 20-IleGlyProLeuProSerIleGlyArg-28 42-ThrGlyThrSerLys-46 101-ArgThrIleProSerValThrGluIle-109 123-PheSerIleLeuAlaLeuIleLysSerLeuIleSer-134 157-LeuTyrArgGlnIleGlnAsnLeuIleThrHisPheAsnPheTyrAlaAla-173 189-GluThrLeuIleGlnHisLeuArgGlnLeuAlaAsp-200 Antigenic Index - Jameson-Wolf 25-SerIleGlyArgProAsnAlaSerThrThrArgProThrSerSerArgProThrGlyThrSerLysIleArgP ro-49 63-SerProAsnThrThrAlaProThrGluSerArgSerArgPheIleAla-78 80-ProLysValLeuProGlyAsnSerSerIle-89 93-IleAlaSerAspLysProTrpMetArg-101 110-ThrValProArgValArgThrSerAlaPheThrAspArgPheSer-124 146-ArgHisSerArgValGlnGlyThr-153 178-PheAspPheAspArgAspPhe-184 209-ThrValAsnAspGlyArgPheAspMetValGlu-219 Hydrophilic Regions - Hopp-Woods 27-GlyArgProAsnAlaSerThrThrArgProThrSerSerArgProThrGlyThrSerLysIleArgPro-49 68-AlaProThrGluSerArgSerArgPheIleAla-78 93-IleAlaSerAspLysProTrp-99 110-ThrValProArgValArgThr-116 146-ArgHisSerArgValGln-151 178-PheAspPheAspArgAspPhe-184 211-AsnAspGlyArgPheAspMetValGlu-219 a279 AMPHI Regions - AMPHI 6-GlyCysLeuIleSer-10 47-AlaAlaSerIleAlaArgSerThrAla-55 58-LeuProAlaIleThrThr-63 74-ThrThrSerSerCysAlaAsp-80 Antigenic Index - Jameson-Wolf 13-XxxArgAlaSerAla-17 29-TrpGluGlyThrAspThrGlySerGlyArgAlaArgLeuAla-42 64-CysProGlyGluLeuLysLeuThr-71 74-ThrThrSerSerCysAlaAspSer-81 88-CysSerSerSerLysProArgIle-95 101-ThrProCysGlyThrAlaAspCysIleSerSerAlaArgXxxArgThrSerLeu-118 120-AlaSerAlaLysSerAsnAlaProAla-128 148-ProProAlaSerGlu-152 Hydrophilic Regions - Hopp-Woods 13-XxxArgAlaSerAla-17 29-TrpGluGlyThrAspThrGlySerGlyArgAlaArgLeuAla-42 66-GlyGluLeuLysLeu-70 89-SerSerSerLysProArgIle-95 110-SerSerAlaArgXxxArgThrSerLeu-118 120-AlaSerAlaLysSerAsnAla-126 a280 AMPHI Regions - AMPHI 27-SerPheΞerIleLeuGlyAspValAlaLys-36 64-AspIleLysLysIleArgSerAla-71 85-AspIleGlnArgAlaValLys-91 97-TyrAlaGluAlaThrLysGlyIleGlnProLeuLys-108 150-AlaTyrAlaGlnAsnValAlaGluAlaLeuIleLys-161 237-ValAlaAlaIleIleArgGlnIleLys-245 247-GluGlyIleLysAlaValPheThrGlu-255 258-LysAspThrArgMetValAspArgIleAlaLysGluThr-270 278-LeuTyrSerAspAlaLeuGlyAsnAlaProAlaAspThrTyrIle-292 Antigenic Index - Jameson-Wolf l-MetLysHisProLys-5 38-IleGlyGlyGluArgValSer-44 51-AlaAsnGlnAspThrHis-56 61-ThrSerGlyAspIleLysLysIleArgSerAlaLys-72 82-GluAlaAlaAspIleGlnArgAlaValLysGlnSerLysValSerTyrAlaGluAlaThrLysGlyIleGln- 105 107-LeuLysAlaGluGluGluGlyGlyHisHisHisAspHisAspHisAspHisAspHisAspHisGluGlyHis HisHisAspHisGlyGluTyrAspProHisValTrpAsnAspPro-145 159-LeuIleLysAlaAspProGluGlyLysValTyrTyr-170 180-GlnLeuLysLysLeuHisSerAspAla-188 196-ProAlaAlaLysArgLysValLeuThr-204 212-MetGlyLysArgTyrHis-217 222-AlaProGlnGlyValSerSerGluAlaGluProSerAlaLysGln-236 242-ArgGlnIleLysArgGluGlyIle-249 255-GluAsnIleLysAspThrArgMetValAspArgIleAlaLysGluThrGlyVal-272 274-ValSerGlyLysLeuTyrSer-280 286-AlaProAlaAspThr-290 295-TyrArgHisAsnIle-299 Hydrophilic Regions - Hopp-Woods l-MetLysHisProLys-5 38-IleGlyGlyGluArgValSer-44 63-GlyAspIleLysLysIleArgSerAlaLys-72 82-GluAlaAlaAspIleGlnArgAlaValLysGlnSerLys-94 99-GluAlaThrLysGly-103 107-LeuLysAlaGluGluGluGlyGlyHisHisHisAspHisAspHisAspHisAspHisAspHisGluGlyHis HisHisAspHisGlyGluTyrAsp-138 159-LeuIleLysAlaAspProGluGly-166 180-GlnLeuLysLysLeuHisSerAspAla-188 196-ProAlaAlaLysArgLysValLeuThr-204 226-ValSerSerGluAlaGluProSerAlaLysGln-236 242-ArgGlnIleLysArgGluGlyIle-249 255-GluAsnIleLysAspThrArgMetValAspArgIleAlaLysGluThrGlyVal-272 a281 AMPHI Regions - AMPHI 62-AlaAlaGlyMetLeuMetAlaLeuLeuAlaGlyLeuValSerArgPhe-77 126-LeuGlnLeuIleAlaAlaValSerThrLeuThr-136 140-LeuAlaValIleTyrArg-145 179-LeuValSerGlyPheGlnAlaLeuGlyThrLeuMetSerVal-192 205-TrpAlaLysHisMet-209 216-SerValLeuThrAlaLeuLeuCysGly-224 Antigenic Index - Jameson-Wolf 25-ArgArgMetSerLeu-29 78-ThrThrLeuLysGluAspAlaAsn-85 102-SerLysAsnGlySerSerVal-108 159-SerValGlyGlyLysGlyGly-165 236-IleProSerGlyPro-240 256-LeuGlyLysGluGlyGlyIle-262 266-TrpLeuLysAsnHisArgHisHisThrThr-275 Hydrophilic Regions - Hopp-Woods 25-ArgArgMetSerLeu-29 78-ThrThrLeuLysGluAspAlaAsn-85 103-LysAsnGlySerSer-107 256-LeuGlyLysGluGlyGlyIle-262 267-LeuLysAsnHisArgHisHisThr-274 a282 AMPHI Regions - AMPHI 10-LeuIleValAlaPheLeuValLeuIleAsnProPheSerAlaLeu-24 50-ValPheAlaValIleAlaValPheAlaLeuIleGlyGlyThrLeu-64 lll-ValArgProAlaArgAsn-116 176-ValSerArgLeuLeu-180 186-ThrIleLeuAsnArgIleMetGlyMet-194 Antigenic Index - Jameson-Wolf 31-ThrAsnGlyHisSerThrLysGluArgArgLysValAlaArg-44 92-AsnGlyAsnAspAsnProAlaLysGlnAsnLeuGlyAlaGlnProGluThrGlyGlnValArgProAlaArgA snAlaGlyAla-119 Hydrophilic Regions - Hopp-Woods 34-HisSerThrLysGluArgArgLysValAlaArg-44 92-AsnGlyAsnAspAsnProAlaLysGlnAsnLeu-102 104-AlaGlnProGluThrGlyGlnValArgProAlaArgAsn-116 a283 AMPHI Regions - AMPHI ll-ThrLeuAlaSerPheLeuPro-17 32-GlyGlyAsnSerTyrSerAspValProLysGlnLeuHis-44 67-AlaAspAlaGlyLysArgThr-73 Antigenic Index - Jameson-Wolf 28-TrpLysAspGlyGlyGlyAsnSerTyrSerAspValProLysGlnLeuHisProAspGlnSerGln-49 53-LeuArgThrArgGlnThrLysProAlaValLysProAlaGlnAlaAspAlaGlyLysArgThrAspGlyAlaA laGlnGluAsnAsnProAspThrAlaGluLysAsnArgGlnLeuGluGluGluLysLysArglleAlaGluThrGl uArgGlnAsnLysGluGluAsnCysArgIleSerLysMetAsnLeu-117 121-GlyAsnSerAsnAlaLysAsnLysAspAspLeuIleArgLysTyrAsnAsnAlaValAsnLysTyrCysArg -144 Hydrophilic Regions - Hopp-Woods 35-SerTyrSerAspValProLys-41 43-LeuHisProAspGlnSerGln-49 53-LeuArgThrArgGlnThrLysProAlaValLysProAlaGlnAlaAspAlaGlyLysArgThrAspGlyAlaA laGlnGluAsnAsnProAspThrAlaGluLysAsnArgGlnLeuGluGluGluLysLysArglleAlaGluThrGl uArgGlnAsnLysGluGluAsnCysArgIleSerLysMetAsnLeu-117 123-SerAsnAlaLysAsnLysAspAspLeuIleArgLysTyrAsn-136 a284 AMPHI Regions - AMPHI 43-GluAlaPheAlaGlyPhePheGluThrVal-52 61-ThrPheAlaAlaArgPhe-66 125-ValAspPheAspValPhe-130 154-ValValPheArgLeuPheArgGlnValValValAsp-165 174-AspThrAlaCysGlyAsnValGlyGly-182 187-AlaAlaAlaPheAlaGlnIleHisGln-195 216-PheValGlnPheIleArgAspAspPheGlyHisGly-227 277-PheArgValPheGlyGlnPheAlaArgGlnPheAla-288 304-PheArgArgGlyPheAspAspGlyPheAspValValAspLys-317 340-AlaAlaLeuHisGlnValHisGlnThrAla-349 352-GlyAspAsnGlnIleAspArgPheAlaGln-361 407-AlaArgAlaPheAlaArgPhePheAlaAlaPheGlyGlnSerLeuGlnSer-423 Antigenic Index - Jameson-Wolf l-MetProSerGluThrArgAsnArgPhe-9 109-PheAspGlyGlnPhe-113 132-HisPheGlyLysArgAsnArgAsnThr rgAla-142 147-GlyAlaProAspAlaVal-152 166-AsnValGlyAsnGlyArgTyrValAspThrAlaCysGlyAsnValGlyGlyAsnGlnAsn-185 209-AlaValGlyGlyGlu-213 219-PheIleArgAspAspPheGlyHisGlyPheGlyGlyArgGluAsnHisAla-235 273-AspPheAspAspPheArg-278 286-GlnPheAlaAspArgAlaValProSerGlyGlyGluGlnGlnSer-300 303-ValPheArgArgGlyPheAspAspGlyPheAspValValAspLysAlaHis-319 347-GlnThrAlaArgArgGlyAspAsnGlnIleAspArgPheAla-360 362-GlyAlaGlyLeuValAlaGluArgCysThrThrAspAspAlaAspGlyThrGluProThr-381 398-PheAlaGlyArgArgGlnHisGlnArgAlaArgAla-409 419-GlnSerLeuGlnSerArg-424 Hydrophilic Regions - Hopp-Woods l-MetProSerGluThrArgAsnArgPhe-9 134-GlyLysArgAsnArgAsnThrArgAla-142 220-IleArgAspAspPheGly-225 229-GlyGlyArgGluAsnHisAla-235 286-GlnPheAlaAspArgAlaValProΞerGlyGlyGluGlnGln-299 306-ArgGlyPheAspAspGlyPheAspValValAspLysAlaHis-319 347-GlnThrAlaArgArgGlyAspAsnGlnIleAspArgPheAla-360 366-ValAlaGluArgCysThrThrAspAspAlaAspGlyThrGlu-379 398-PheAlaGlyArgArgGlnHisGlnArgAlaArgAla-409 a285-l AMPHI Regions - AMPHI 15-ValCysPheLeuGly-19 34-GlnIleProSerTrp-38 50-GlyThrLeuLeuAspGlyPheAsp-57 116-SerLeuProAspSerIleAspLeuPro-124 208-HisSerThrAlaArg-212 240-HisProPheAlaGluSerLeuAspLysThrLeuGluGluValLeu-254 266-ValProSerLeuPro-270 280-AlaIleProSerPheSerAsp-286 313-GlnValLeuGlySer-317 592-IleGlyLysAlaAlaAspIle-598 609-ProAspThrSerArg-613 629-GlyAlaGluValValAsp-634 671-GlyIleAsnArgGluLeuThrArgTrp-679 747-IleAlaGluLeuHisAsnPhePheLysProProPhe-758 776-AlaArgGlyTyrLeu-780 836-PheGlyGlyAsnMetAlaAsn-842 848-ArglleThrAlaSerLeuProAspLeuGlyThrLeu-859 868-GlnAsnIleThrGlySerLeuAsnAlaAla-877 955-GlySerIleAlaAsp-959 1008-ThrAlaGluLeuSer-1012 1061-ValThrGlyMetIleLys-1066 1135-SerGlyGlySerValArgGlyValGlyThrValArg-1146 1165-ThrValSerPheValGlyProLeuAsn-1173 1190-AlaGlyValGluIleLeuGlySerLeuAsn-1199 1244-LeuAlaGlyGlnIle-1248 1305-ValLysLeuIleTyrArgLeuThrArgAlaIleGlnAlaValAlaArgIleGlySer-1323 Antigenic Index - Jameson-WoIf 43-IleSerSerGlnAsnLeuLysGlyThrLeuLeuAspGlyPheAspGlyAspAsnTrpSerIleGluThrGluG lyAlaAspLeuLys11eSerArg-74 80-LysProSerGluLeuMetArgArgSerLeuHis-90 104-LysProThrProProLysGluGluArgProProLeuSerLeuProAspSerIleAsp-122 130-AspArgPheGluThrGlyLysIleSerMetGlyLysAlaPheAspLysGlnThrValTyr-149 151-GluArgLeuAspAlaSerTyrArgTyrAspArgLysGlyHisArgLeuAspLeuLysAlaAlaAspThrPro TrpSerSerSerSerGlySerAla-182 185-GlyLeuLysLysProPheAla-191 198-ThrLysGlyGlyLeuGluGlyLysThrIle-207 209-SerThrAlaArgLeuSerGlySerLeuLysAspValArgAla-222 224-LeuAlaIleAspGlyGlyAsnIleArgLeuSerGlyLysSer-237 244-GluSerLeuAspLysThrLeuGlu-251 268-SerLeuProAspAla-272 292-GlySerLeuAspLeuGluAsnThrLys-300 302-GlyPheAlaAspArgAsnGlyIleProVal-311 320-IleArgGlnAspGlyThrValHis-327 337-GlyArgGlyGlyIleArgLeuSerGlyLysIleAspThrGluLysAspIleLeu-354 362-SerValGlyAlaGluAspValLeu-369 372-AlaPheLysGlyArgLeuAspGlySerIle-381 387-ThrAlaSerProLysIle-392 400-ThrAlaArgThrAspGlySerLeu-407 411-SerAspProAlaAsnGlyGlnArgLysLeuVal-421 430-GlyGlnGlySerLeuThr-435 442-LeuPheLysAspArgLeuLeuLysLeuAspIleArgSerArgAlaPheAspProSerArgIleAspProGln Leu-466 480-GluLeuAlaLysGluLysPheThrGlyLys-489 508-IleValTyrGluSerArgHisLeuProArgAlaAlaVal-520 522-LeuArgLeuGlyArgAsnIleIleLysThrAspGlyGlyPheGlyLysLysGlyAspArgLeuAsn-543 548-AlaProAspLeuSerArgPheGly-555 563-AsnValArgGlyHisLeuSerGlyAspLeuAspGlyGlyIleArgThrPheGluThrAspLeuSerGlyAla Ala-587 594-LysAlaAlaAspIleArgSer-600 605-LeuLysGlySerProAspThrSerArgProIleArgAlaAspIleLysGlySerArgLeuSerLeuSerGly GlyAlaGluValValAspThrAlaAspLeuMetLeuAspGlyThrGlyVal-645 647-HisArgIleArgThr-651 656-ThrLeuAspGlyLysProPheLysPheAspLeuAspAlaSerGlyGlyIleAsnArgGluLeuThrArgTrp LysGlySerIle-683 696-LeuGlnAsnArgMetThrLeu-702 704-AlaGlyAlaGluArgValAla-710 729-SerTrpAspLysLysThrGlyIleSerAlaLysGlyGlyAla-742 764-LeuAsnGlyAspTrp-768 772-TyrGlyArgAsnAlaArgGly-778 782-IleSerArgGlnSerGlyAspAlaValLeu-791 803-SerLeuLysThrArgPheGlnAsnAspArgIleGly-814 817-LeuAspGlyGlyAlaArgPheGlyArgIleAsnAlaAspLeuAspIle-832 844-ProLeuGlyGlyArgIleThr-850 882-GlyArgValGlySerProSerVal-889 893-ValAsnGlySerSerAsnTyrGlyLysIleAsnGly-904 908-ValGlyGlnSerArgSerPheAspThrAlaProLeuGlyGlyArgLeuAsn-924 941-GlnThrValLysGlySerLeu-947 956-SerIleAlaAspProHisLeuGlyGly-964 966-11eAsnGlyAspLysLeuTyrTyrArgAsnGlnThr-977 982-LeuAspAsnGlySerLeuArg-988 991-IleAlaGlyArgLysTrpVal-997 1001-LeuLysPheArgHisGluGlyThrAlaGluLeuSerGly-1013 1015-ValGlyMetGluAsnSerGlyProAspValAspIle-1026 1031-AspLysTyrArgIleLeuSerArgProAsnArgArgLeuThr-1044 1047-GlyAsnThrArgLeuArgTyrSerProGlnLysGlyIle-1059 1065-IleLysThrAspGlnGlyLeuPheGlySerGlnLysSerSerMetProSerValGlyAspAspVal-1086 1091-GluValLysLysGluAlaAla-1097 1109-AspLeuAsnAspGlyIleArg-1115 1134-GlnSerGlyGlySerValArgGlyValGly-1143 1146-ArgValIleLysGlyArgTyrLysAlaTyrGlyGlnAspLeuAspIleThrLysGlyThr-1165 1171-ProLeuAsnAspProAsnLeuAsnIleArgAlaGluArgArgLeuSerProValGly-1189 1197-SerLeuAsnSerProArgIle-1203 1207-AlaAsnGluProMetSerGluLysAspLysLeu-1217 1225-AlaGlySerGlySerSerGlyAspAsnAlaAla-1235 1246-GlyGlnIleAsnAspArgIleGlyLeu-1254 1256-AspAspLeuGlyPheThrSerLysArgSerArgAsnAlaGlnThrGlyGluLeuAsnProAlaGlu-1277 1283-GlyLysGlnLeuThrGlyLys-1289 1299-SerSerAlaGluGlnSerVal-1305 1321-IleGlySerArgSerSerGlyGlyGluLeu-1330 1335-ArgPheAspArgPheSerGlySerAspLysLysAspSerAlaGlyAsnSerLysGlyLys-1354 Hydrophilic Regions - Hopp-Woods 56-PheAspGlyAspAsnTrpSerIleGluThrGluGlyAlaAspLeuLysIleSerArg-74 83-GluLeuMetArgArgSerLeuHis-90 105-ProThrProProLysGluGluArgProPro-114 130-AspArgPheGluThrGlyLys-136 141-LysAlaPheAspLys-145 151-GluArgLeuAspAla-155 157-TyrArgTyrAspArgLysGlyHisArgLeuAspLeuLysAlaAlaAsp-172 200-GlyGlyLeuGluGlyLysThrIle-207 215-GlySerLeuLysAspValArgAla-222 244-GluSerLeuAspLysThrLeuGlu-251 292-GlySerLeuAspLeuGluAsnThrLys-300 302-GlyPheAlaAspArgAsnGlyIlePro-310 320-IleArgGlnAspGly-324 343-LeuSerGlyLysIleAspThrGluLysAspIleLeu-354 364-GlyAlaGluAspValLeu-369 373 -PheLysGlyArgLeuAspGly-379 401-AlaArgThrAspGly-405 412-AspProAlaAsnGlyGlnArgLysLeuVal-421 442-LeuPheLysAspArgLeuLeuLysLeuAspIleArgSerArgAlaPheAspProSerArgIleAspPro-46 4 480-GluLeuAlaLysGluLysPheThrGly-488 508-IleValTyrGluSerArgHisLeuPro-516 522-LeuArgLeuGlyArgAsnIleIleLysThrAspGlyGlyPheGlyLysLysGlyAspArgLeuAsn-543 570-GlyAspLeuAspGlyGlyIleArgThrPheGluThrAspLeuSerGlyAlaAla-587 594-LysAlaAlaAspIleArgSer-600 607-GlySerProAspThrSerArgProIleArgAlaAspIleLysGlySerArgLeuSerLeu-626 631-GluValValAspThrAlaAspLeuMetLeu-640 647-HisArgIleArgThr-651 657-LeuAspGlyLysProPheLysPheAspLeuAspAla-668 670-GlyGlyIleAsnArgGluLeuThrArgTrpLysGly-681 704-AlaGlyAlaGluArgValAla-710 729-SerTrpAspLysLysThrGlyIleSerAlaLysGlyGlyAla-742 783-SerArgGlnSerGly-787 806-ThrArgPheGlnAsnAspArgIle-813 819-GlyGlyAlaArgPheGlyArgIleAsnAlaAspLeuAspIle-832 1001-LeuLysPheArgHisGluGlyThrAlaGluLeu-lOll 1017-MetGluAsnSerGlyProAspValAspIle-1026 1031-AspLysTyrArgIleLeuSerArgProAsnArgArgLeuThr-1044 1049-ThrArgLeuArgTyrSerPro-1055 1065-IleLysThrAspGln-1069 1075-GlnLysSerSerMet-1079 1091-GluValLysLysGluAlaAla-1097 1109-AspLeuAsnAspGlyIleArg-1115 1146-ArgValIleLysGlyArgTyrLysAlaTyrGlyGlnAspLeuAspI1eThrLys-1163 1179-IleArgAlaGluArgArgLeuSer-1186 1209-GluProMetSerGluLysAspLysLeu-1217 1225-AlaGlySerGlySerSerGlyAspAsnAlaAla-1235 1248-IleAsnAspArgIleGlyLeu-1254 1259-GlyPheThrSerLysArgSerArgAsnAlaGlnThrGlyGluLeuAsnPro-1275 1300-SerAlaGluGlnSerVal-1305 1321-IleGlySerArgSerSerGlyGly-1328 1335-ArgPheAspArgPheSerGlySerAspLysLysAspSerAlaGlyAsnSerLysGlyLys-1354 a286 AMPHI Regions - AMPHI 69-GluIleLysAspMetVal-74 102-ProAspAsnValLysThr-107 145-ValAlaIleLeuGlyAsp-150 157-LeuAlaGluTyrTyrArgAsnAlaLeuGluAsnTrpGlnGlnProValGlySer-174 198-ProLeuAlaLysLeuGlyAsn-204 238-ThrGlnArgTyrProGluGlnIleValSerGlyLeuAlaArgPheGlnProGlyThr-256 326-AspTyrTyrAsnLeuPheAsnLys-333 354-IleSerGlnProArg-358 375-ThrThrGlnAsnLeu-379 428-ThrAlaSerTrpLysArgGlnLeuLeu-436 455-ThrLeuGlyAlaPhe-459 513-GlyAlaSerSerVal-517 555-LeuSerGlyAlaValPheHisAspMetGlyAspAlaAlaAlaAsn-569 584-ArgTrpPheSerProLeu-589 Antigenic Index - Jameson-Wolf l-MetHisAspThrArgThrMetMet-8 30-AlaAspLeuSerGluAsnLysAla-37 43-PheLysAsnLysSerProAspThrGluSerValLysLeuLysProLysPheProVal-61 63-IleAspThrGlnAspSerGluIleLysAspMetValGluGluHisLeu-78 83-GlnGlnGlnGluGluValLeuAspLysGluGlnThr-94 97-LeuAlaGluGluAlaProAspAsnValLysThrMetLeuArgSerLysGlyTyrPheSerSerLysValSerL euThrGluLysAspGlyAla-127 133-ThrProGlyProArgThrLysIle-140 151-IleLeuSerAspGlyAsnLeuAlaGluTyrTyrArgAsnAlaLeuGluAsnTrpGln-169 172-ValGlySerAspPheAspGlnAspSerTrpGluAsnSerLysThrSerVal-188 192-ValThrArgLysAlaTyrPro-198 201-LysLeuGlyAsnThrArgAlaAlaValAsnProAspThrAlaThrAla-216 223-AspSerGlyArgProIleAla-229 234-GluIleThrGlyThrGlnArgTyrProGluGlnIle-245 252-PheGlnProGlyThrProTyrAspLeu-260 270-LeuGluGlnAsnGlyHisTyrSerGly-278 283-AlaAspPheAspArgLeuGlnGlyAspArgValProVal-295 298-SerValThrGluValLysArgHisLysLeuGluThrGlyIleArgLeuAspSerGluTyrGlyLeuGlyGly -321 342-AspMetAspLysTyrGluThr-348 355-SerGlnProArgAsnTyrArgGlyAsnTyrTrp-365 368-AsnValSerTyrAsnArgSerThrThrGlnAsnLeuGluLysArgAlaPheSerGlyGly-387 391-ValArgAspArgAlaGlyIleAspAlaArgLeuGly-402 405-PheLeuAlaGluGlyArgLysIleProGlySerAspIleAspLeuGlyAsnSerHisAla-424 430-SerTrpLysArgGlnLeu-435 441-HisProGluAsnGlyHisTyrLeuAspGlyLysIle-452 468-ThrSerAlaArgAlaGly-473 476-PheThrProGluAsnLysLysLeu-483 496-ValAlaArgAspAsnAlaAsnValPro-504 509-PheArgSerGlyGlyAlaSerSerValArgGlyTyrGluLeuAspSer-524 534-ValLeuProGluArgAlaLeu-540 562-AspMetGlyAspAla-566 568-AlaAsnPheLysArgMetLysLeuLysHisGlySerGlyLeu-581 598-TyrGlyHisSerAspLysLysIleArg-606 Hydrophilic Regions - Hopp-Woods 1-MetHisAspThrArgThrMe Met-8 30-AlaAspLeuSerGluAsnLysAla-37 44-LysAsnLysSerProAspThrGluSerValLysLeuLysProLysPheProVal-61 63-IleAspThrGlnAspSerGluIleLysAspMetValGluGluHisLeu-78 84-GlnGlnGluGluValLeuAspLysGluGlnThr-94 97-LeuAlaGluGluAlaProAspAsnValLysThrMetLeuArgSer-lll 119-ValSerLeuThrGluLysAspGlyAla-127 134-ProGlyProArgThrLysIle-140 174-SerAspPheAspGlnAspSerTrpGluAsnSerLysThr-186 192-ValThrArgLysAlaTyrPro-198 206-ArgAlaAlaValAsnProAspThrAlaThr-215 239-GlnArgTyrProGlu-243 283-AlaAspPheAspArgLeuGlnGlyAspArgValProVal-295 298-SerValThrGluValLysArgHisLysLeuGluThrGlyIleArgLeuAspSerGluTyr-317 342-AspMetAspLysTyrGluThr-348 373 -ArgSerThrThrGlnAsnLeuGluLysArgAlaPhe-384 392-ArgAspArgAlaGlyI1eAspAlaArgLeuGly-402 405-PheLeuAlaGluGlyArgLysIleProGlySerAspIleAspLeu-419 478-ProGluAsnLysLysLeu-483 496-ValAlaArgAspAsnAlaAsn-502 518-ArgGlyTyrGluLeuAspSer-524 534-ValLeuProGluArgAlaLeu-540 562-AspMetGlyAspAla-566 568-AlaAsnPheLysArgMetLysLeuLysHis-577 600-HisSerAspLysLysIleArg-606 a287 AMPHI Regions - AMPHI 29-LysSerAlaAspThrLeuSerLysProAlaAla-39 77-GlyGlyGlnAspMet-81 109-AsnAspMetProGlnAsn-114 131-MetProThrArgAspMetGlyAsnGlnAlaProAspAlaGlyGluSerAlaGlnProAlaAsnGlnProAsp MetAlaAsnAlaAlaAspGlyMet-162 171-GluAsnAlaGlyAsnThrAlaAspGlnAlaAlaAsnGlnAlaGluAsn-186 192-SerGlnAsnProAla-196 206-GlyGlySerAspPhe-210 213-IleAsnValAlaAsnGly-218 256-LeuSerAspGluGluLys11eAsnLysTyrLysLys-267 306-PheArgArgSerAlaArg-311 419-LysSerValAspGlyIleIleAspSer-427 447-PheLysGlyThrTrpThr-452 459-ValSerGlyArgPheTyr-464 Antigenic Index - Jameson-Wolf 17-AlaCysGlyGlyGlyGlyGlyGlySerProAspValLysSerAlaAspThrLeuSerLysProAla-38 42-ValThrGluAspValGlyGluGluValLeuProLysGluLysLysAspGluGluAlaValSerGlyAlaProG lnAlaAspThrGlnAspAlaThrAlaGlyLysGlyGlyGlnAspMet-81 85-SerAlaGluAsnThrGlyAsnGlyGlyAlaAlaThrThrAspAsnProGluAsnLysAspGluGlyProGlnA snAspMetProGlnAsnAlaAlaAspThrAspSerSerThrProAsnHisThrProAlaProAsnMetProThrAr gAspMetGlyAsnGlnAlaProAspAlaGlyGluSerAlaGlnProAlaAsnGlnProAspMetAlaAsnAlaAla AspGlyMetGlnGlyAspAspProSerAlaGlyGluAsnAlaGlyAsnThrAlaAspGlnAlaAlaAsnGlnAlaG luAsnAsnGlnValGlyGlySerGlnAsnProAlaSerSerThrAsnProAsnAlaThrAsnGlyGlySerAspPh eGlyArg-212 214-AsnValAlaAsnGlyIleLysLeuAspSerGlySerGluAsnVal-228 232-HisCysLysAspLysValCysAspArgAspPheLeuAspGluGluAlaProProLysSerGluPheGluLys LeuSerAspGluGluLys11eAsnLysTyrLysLysAspGluGlnArgGluAsnPhe-274 278-ValAlaAspArgValGluLysAsnGlyThrAsnLys-289 293-IleTyrLysAspLysSerAlaSerSerSerSerAlaArgPheArgArgSerAlaArgSerArgArgSerLeu ProAla-318 332-IleValAspGlyGluAla-337 342-GlyHisSerGlyAsn-346 349-AlaProGluGlyAsnTyrArgTyrLeu-357 360-GlyAlaGluLysLeuSerGlyGlySer-368 374-GlnGlyGluProAlaLysGlyGluMet-382 397-HisMetGluAsnGlyArgProSerProSerGlyGlyArgPheAlaAla-412 414-ValAspPheGlySerLysSerValAspGlyIleIleAspSerGlyAspAspLeuHisMetGlyThrGlnLys Phe-438 442-IleAspGlyAsnGlyPheLysGlyThrTrpThrGluAsnGlyGlyGlyAspValSerGly-461 463-PheTyrGlyProAlaGlyGluGluValAlaGlyLysTyrSerTyrArgProThrAspAlaGluLysGlyGly Phe-487 491-AlaGlyLysLysGluGlnAsp-497 Hydrophilic Regions - Hopp-Woods 22-GlyGlyGlySerProAspValLysSerAlaAspThrLeuSerLysProAla-38 42-ValThrGluAspValGlyGluGluValLeuProLysGluLysLysAspGluGluAlaValSer-62 65-ProGlnAlaAspThrGlnAspAlaThrAlaGlyLysGlyGlyGlnAsp-80 85-SerAlaGluAsnThrGly-90 95-AlaThrThrAspAsnProGluAsnLysAspGluGlyProGlnAsnAspMetProGlnAsnAlaAlaAspThrA spSerSerThr-122 131-MetProThrArgAspMetGlyAsnGlnAlaProAspAlaGlyGluSerAlaGln-148 151-AsnGlnProAspMetAlaAsnAlaAlaAspGlyMetGlnGlyAspAspProSerAlaGlyGluAsnAlaGly AsnThrAlaAspGlnAlaAlaAsnGlnAlaGluAsnAsnGln-188 193-GlnAsnProAlaSer-197 206-GlyGlySerAspPheGlyArg-212 219-IleLysLeuAspSerGlySerGlu-226 232-HisCysLysAspLyΞValCysAspArgAspPheLeuAspGluGluAlaProProLysSerGluPheGluLys LeuSerAspGluGluLysIleAsnLysTyrLysLysAspGluGlnArgGluAsnPhe-274 278-ValAlaAspArgValGluLysAsnGlyThr-287 294-TyrLysAspLysSerAlaSerSerSerSerAlaArgPheArgArgSerAlaArgSerArgArgSerLeuPro -317 332-IleValAspGlyGluAla-337 360-GlyAlaGluLysLeuSer-365 374-GlnGlyGluProAlaLysGlyGluMet-382 399-GluAsnGlyArgProSerProSerGlyGly-408 414-ValAspPheGlySerLysSerValAspGlyIleIleAspSerGlyAspAspLeuHis-432 455-GlyGlyGlyAspValSer-460 467-AlaGlyGluGluValAlaGly-473 475-TyrSerTyrArgProThrAspAlaGluLysGlyGly-486 491-AlaGlyLysLysGluGlnAsp-497 a288 AMPHI Regions - AMPHI 7-ValSerArgValLeu-ll 54-IleValThrLysCysAla-59 61-ArgProTyrArgThrPheSerProLeuProVal-71 97-HisSerThrLeuArg-101 150-AlaLeuPheGlnAlaGlyPheAspLysAlaValGln-161 Antigenic Index - Jameson-Wolf 2-HisThrGlyGlnAla-6 28-AsnLeuProGluArgSerAlaGlySer-36 58-CysAlaValArgProTyrArgThrPheSerPro-68 72-LeuProLysGlnProSerAla-78 89-LeuProArgProAlaValAsnArgHisSerThrLeuArgSerProAspPheProProArgMet-109 113-IleArgGlyAspCysLeuPro-119 126-IleIleThrArgAsnAlaLysMetProSerGluThrValGlnValSerAspGlyIleGlnProLys-147 155-GlyPheAspLysAlaVal-160 Hydrophilic Regions - Hopp-Woods 28-AsnLeuProGluArgSerAla-34 58-CysAlaValArgPro-62 98-SerThrLeuArgSerProAspPheProPro-107 113-IleArgGlyAspCys-117 126-IleIleThrArgAsnAlaLysMetProSerGluThrValGlnVal-140 155-GlyPheAspLysAlaVal-160 a292 AMPHI Regions - AMPHI 7-LysIleLeuThrProPheThrValLeuProLeu-17 40-GlyLysSerValAla-44 62-ValLeuSerValSerGlu-67 69-ProValLysGlyIleTyrGlu-75 110-GluArgAlaAlaAspLeu-115 124-ProLeuAspLysAlaIleLysGluValArgGly-134 150-PheCysLysArgLeuGluHisGluPheGluLysMetThrAspValThr-165 195-LysAlaTrpThrAspTrpMetArg-202 212-IleCysAspAsnProVal-217 Antigenic Index - Jameson-Wolf l-MetLysThrLysLeu-5 23-ThrProValSerAsnAlaAsnAlaGluProAlaValLysAlaGluSerAlaGlyLysSerVal-43 47-LeuLysAlaArgLeuGluLysThrTyrSerAlaGlnAspLeuLys-61 66-SerGluThrProValLysGlyIle-73 85-TyrThrAspAlaGluGlyGlyTyr-92 99-IleAsnIleAspThrArgLysAsnLeuThrGluGluArgAlaAlaAspLeuAsnLys-117 124-ProLeuAspLysAlaIleLysGluValArgGlyAsnGlyLysLeuLysVal-140 142-ValPheSerAspProAspCysProPhe-150 152-LysArgLeuGluHisGluPheGluLysMetThrAsp-163 177-HisProAspAlaAlaArgLysAla-184 189-CysGlnProAspArgAlaLysAla-196 200-TrpMetArgLysGlyLysPheProVal-208 210-GlySerIleCysAspAsnProValAlaGluThrThrSerLeuGlyGlu-225 237-PheProAsnGlyArgSerGlnSerGlyTyrSerPro-248 250-ProGlnLeuGluGluIleIleArgLysAsnGln-260 Hydrophilic Regions - Hopp-Woods l-Me LysThrLysLeu-5 28-AlaAsnAlaGluProAlaValLysAlaGluSerAlaGlyLysSerVal-43 47-LeuLysAlaArgLeuGluLysThrTyrSer-56 99-IleAsnIleAspThrArgLysAsnLeuThrGluGluArgAlaAlaAspLeuAsnLys-117 124-ProLeuAspLysAlaIleLysGluValArgGlyAsnGlyLysLeuLys-139 144-SerAspProAspCysProPhe-150 152-LysArgLeuGluHisGluPheGluLysMetThrAsp-163 179-AspAlaAlaArgLysAla-184 190-GlnProAspArgAlaLysAla-196 200-TrpMetArgLysGlyLysPhe-206 240-GlyArgSerGlnSer-244 250-ProGlnLeuGluGluIleIleArgLysAsnGln-260 a294 AMPHI Regions - AMPHI 27-ArgPheProAlaAlaPheArgArgTyrSer-36 45-LysProAlaGlyThr-49 51-TrpHisArgValArgArgPheLysSerAsnArgArgThr-63 65-GlyGlyLysProLeuLysLysThrTyrArg-74 92-AsnIleAlaGluArgAlaArgGluSerProArgArgTyrGlyLysArgTyrAlaAspIleGlyAspAsp-114 133-AlaValAlaHisIleValHisLeu-140 176-AlaMetSerTyrArg-180 206-SerIleLeuGlyGluProPheAlaThrSerPheGly-217 227-AlaPheSerValLeuAlaHisPhe-234 247-ThrValGlyTrpSerLysTyrIleHisThrVal-257 Antigenic Index - Jameson-Wolf 20-AlaValArgThrSerSerAsnArgPhe-28 32-PheArgArgTyrSerAlaPheArg-39 44-ProLysProAlaGlyThrProTrpHisArgValArgArgPheLysSerAsnArgArgThrArgGlyGlyLysP roLeuLysLysThrTyrArgProArgArgAlaGluCysArgCysArgArgAlaArgThr-87 93-IleAlaGluArgAlaArgGluSerProArgArgTyrGlyLysArgTyrAlaAspIleGlyAspAspSerAspT hrIleArg-119 121-ArgValPheArgLeuGluTyr-127 161-HisThrGlyArgValSerCysGluAlaArgArgGluValGluLysAlaMetSer-178 240-LysMetAlaArgSer-244 Hydrophilic Regions - Hopp-Woods 20-AlaValArgThrSerSerAsnArg-27 52-HisArgValArgArgPheLysSerAsnArgArgThrArgGlyGlyLysProLeuLysLysThrTyrArgProA rgArgAlaGluCysArgCysArgArgAlaArgThr-87 93-IleAlaGluArgAlaArgGluSerProArgArgTyrGlyLysArgTyrAlaAspIleGlyAspAspSerAspT hrIleArg-119 121-ArgValPheArgLeuGluTyr-127 165-ValSerCysGluAlaArgArgGluValGluLysAlaMetSer-178 a295 AMPHI Regions - AMPHI 79-PheArgGlnProArg-83 112-ArgPhePheArgGlnPro-117 130-AlaPheLeuHisGlnIle-135 175-AsnLeuArgGlyPhePro-180 188-HisGlnGlnArgArgIleGlyLysThrLeuProGlnLeu-200 232-ThrLeuAlaProMetArgProIleCysArgGlyThrSerGly-245 262-TyrIleIleLysProLeuGluHis-269 Antigenic Index - Jameson-Wolf 4-MetAlaArgHisAspAspGlnGlnGly-12 18-LeuProArgArgGlnGln-23 49-PheLysLeuProArgGlnArgPheHisLeu-58 73-HisGlyCysArgAlaGlnPheArgGlnProArgArgIleArgLeu-87 91-GlnThrAlaArgGlnArgSerGlyGlyArgThrAspGlnAlaAla-105 114-PheArgGlnProArgIleArgGlnLysGlnArgHisThrArg-127 136-GlyProAspPheGly-140 143-GlnAsnAlaGluHisArgAla-149 170-CysIleArgLysGlnAsnLeuArgGlyPheProSerArgArgGlyHisLeuArgHisGlnGlnArgArgIle GlyLysThrLeu-197 205-LeuGlyGlyThrArgPheProAspArgAsnGlyValTyrProAsnArgAlaGlyAsnGlyIleArgIleArg Leu-229 238-ProIleCysArgGlyThrSerGly-245 252-ProTyrProTyrArgArgLysGlnProGlnTyr-262 273-SerCysLysThrAsnAlaValArgThrValArgThrAlaPheArgGlnArgAsnGlnIleSer-293 Hydrophilic Regions - Hopp-Woods 5-AlaArgHisAspAspGlnGlnGly-12 18-LeuProArgArgGlnGln-23 77-AlaGlnPheArgGlnProArgArgIleArgLeu-87 93-AlaArgGlnArgSerGlyGlyArgThrAspGlnAlaAla-105 117-ProArgIleArgGlnLysGlnArgHisThrArg-127 145-AlaGluHisArgAla-149 170-CysIleArgLysGlnAsnLeu-176 179-PheProSerArgArgGlyHisLeuArgHisGlnGlnArgArgIleGlyLys-195 209-ArgPheProAspArgAsnGly-215 225-IleArgIleArgLeu-229 238-ProIleCysArgGlyThr-243 254-ProTyrArgArgLysGlnPro-260 280-ArgThrValArgThrAlaPheArgGlnArgAsnGlnIle-292 a297 AMPHI Regions - AMPHI 35-ArgThrG1uArgVa1-39 69-GlnProGlyAspSerLeuAlaAspValLeuAla-79 86-AspGluIleAlaArgIleThrGluLysTyr-95 157-LeuProThrLeuArg-161 199-LeuLysGluGlyAspAla-204 272-LeuValTyrThrArgIleSerSer-279 333-HisAlaAsnGlyValGluThrLeuTyrAlaHisLeuSerAlaPheSer-348 Antigenic Index - Jameson-Wolf 8-AlaLysHisArgLysTyrAla-14 32-SerThrGluArgThrGluArgValArgProGlnArgValGluGlnLysLeuPro-49 52-SerTrpGlyGlySerGly-57 67-AlaValGlnProGlyAspSerLeuAla-75 78-LeuAlaArgSerGlyMetAlaArgAspGluIleAlaArgIleThrGluLysTyrGlyGlyGluAlaAspLeuA rgHisLeuArgAlaAspGlnSerVal-110 115-GlyGlyAspGlyGlyAlaArgGluVal-123 127-ThrAspGluAspGlyGluArgAsnLeuValAlaLeuGluLysLysGlyGlyIleTrpArgArgSerAlaSer GluAlaAspMetLysVal-156 167-ThrSerAlaArgGlySerLeuAlaArgAlaGluValProValGluIleArgGluSerLeuSer-187 194-PheSerLeuAspGlyLeuLysGluGlyAspAlaVal-205 228-GluValValLysGlyGlyThrArgHis-236 240-TyrTyrArgSerAspLysGluGlyGlyGlyGlyGlyAsnTyrTyrAspGluAspGlyArgValLeuGlnGlu LysGlyGlyPheAsn-268 276-ArgIleSerSerProPheGlyTyr-283 295-HisThrGlyIleAspTyrAla-301 303-ProGlnGlyThrProValArgAlaSerAlaAspGly-314 318-PheLysGlyArgLysGlyGlyTyrGly-326 333-HisAlaAsnGlyValGlu-338 350-AlaGluGlyAsnValArgGlyGlyGlu-358 365-SerThrGlyArgSerThrGlyProHisLeu-374 376-TyrGluAlaArgIleAsnGlyGlnProValAsn-386 393-ProThrProGluLeuThrGlnAlaAspLysAlaAla-404 408-GlnLysGlnLysAlaAspAlaLeu-415 426-ValSerGlnSerAsp-430 Hydrophilic Regions - Hopp-Woods 8-AlaLysHisArgLysTyrAla-14 32-ΞerThrGluArgThrGluArgValArgProGlnArgValGluGlnLysLeu-48 68-ValGlnProGlyAspSerLeuAla-75 82-GlyMetAlaArgAspGluIleAlaArgIleThrGluLysTyrGlyGlyGluAlaAspLeuArgHisLeuArgA laAspGln-108 117-AspGlyGlyAlaArgGlu-122 127-ThrAspGluAspGlyGluArgAsnLeuValAlaLeuGluLysLysGlyGlyIleTrpArgArgSerAlaSer GluAlaAspMetLysVal-156 167-ThrSerAlaArgGlySerLeuAlaArgAlaGluValProValGluIleArgGluSerLeu-186 194-PheSerLeuAspGlyLeuLysGluGlyAspAlaVal-205 228-GluValValLysGlyGlyThrArg-235 242-ArgSerAspLysGluGlyGlyGly-249 253-TyrTyrAspGluAspGlyArgValLeuGlnGluLysGlyGlyPhe-267 306-ThrProValArgAlaSerAla-312 319-LysGlyArgLysGlyGlyTyr-325 350-AlaGluGlyAsnValArgGlyGlyGlu-358 366-ThrGlyArgSerThrGly-371 378-AlaArgIleAsnGly-382 396-GluLeuThrGlnAlaAspLysAlaAla-404 408-GlnLysGlnLysAlaAspAlaLeu-415 a298 AMPHI Regions - AMPHI 6-SerLeuPheAlaSerIleLeuMetSerAlaLeuIleAla-18 26-IleAsnAlaTyrTrpGlnGln-32 42-ProLeuAlaAlaTyr-46 62-LeuSerAspGlyIleLysAlaPhe-69 82-GlySerAlaAspMetPro-87 134-ValGlnLysSerLeuLys-139 157-SerTyrProSerPhePheAspTrpProLysThrIleGluGluThrLeuLysLysHisProGlu-177 188-AsnAspProTrpAsp-192 208-AlaGlnGluTyrLeuLysArgValAspArgIleLeuGluAlaAlaHis-223 245-GlnMetArgTyrLeuAspLysLeuLeuSerGluTyrLeu-257 276-ArgTyrThrAspSer-280 308-AlaLysIleMetGluLys-313 Antigenic Index - Jameson-Wolf 22-SerGlnAsnProIleAsnAlaTyr-29 34-TyrHisArgAsnSerProLeuGluPro-42 47-GlyTrpTrpArgSerGlyAlaAlaLeuGlnGlu-57 70-LeuSerGlyGluThrProProThrAlaGlnAspGlyGlySerAlaAspMetProSerGluAlaAlaAlaProG luThrAlaProGlnThrGlyGluThrGluTrpLysGlnAsnThrGlu-109 114-ArgThrGlyAspLys-118 136-LysSerLeuLysGlnGlnTyrGlyIleGluSerValAsnLeuSerLysGlnSerThrGly-155 162-PheAspTrpProLysThrIleGluGluThrLeuLysLysHisProGlu-177 186-GlyProAsnAspProTrp-191 194-ProValGlyLysArgTyrLeu-200 203-AlaSerAspGluTrpAla-208 211-TyrLeuLysArgValAspArgIleLeuGlu-220 236-TyrMetLysLysAlaLysLeuAspGlyGlnMetArgTyrLeuAsp-250 270-LeuSerGlyGlyLysAspArgTyrThrAspSerValAsnValAsnGlyLysProValArgTyrArgSerLys AspGlyIle-296 318-ProSerThrGlnProSerSerThrGlnPro-327 Hydrophilic Regions - Hopp-Woods 73-GluThrProProThrAlaGlnAspGlyGlySerAlaAspMetProSerGluAlaAlaAlaProGluThrAlaP roGlnThrGlyGluThrGluTrpLysGlnAsnThrGlu-109 148-AsnLeuSerLysGlnSerThr-154 166-LysThrIleGluGluThrLeuLysLysHisProGlu-177 211-TyrLeuLysArgValAspArgIleLeuGlu-220 236-TyrMetLysLysAlaLysLeuAspGlyGlnMetArgTyrLeuAsp-250 271-SerGlyGlyLysAspArgTyrThrAsp-279 281-ValAsnValAsnGlyLysProValArgTyrArgSerLysAspGlyIle-296 319-SerThrGlnProSerSerThrGlnPro-327 a299 AMPHI Regions - AMPHI 54-AlaSerProTrpMetLysLysLeuGlnSerValAlaGlnGlySer-68 71-ThrPheArgIleLeuGlnIleGly-78 85-AspPhePheThrAspSerLeuArgLysArgLeuGlnLysThrTrpGly-100 238-GlnLeuThrGlnTrpSerLysTrp-245 247-AlaAspArgMetAsnAspLeuAlaGlnThr-256 281-GluGlnLysTrpLeuAspThrValArgGlnIleArgAspSerLeu-295 307-GluSerLeuLysAsnThrLeu-313 322-ArgLeuThrGluValGlnGlnMetGlnArgArgIleAlaArgGln-336 375-TyrGlnArgSerAlaGluMetLeuAlaAspSerLeuGluGluLeuValArgSerAlaAlaIleArg-396 Antigenic Index - Jameson-Wolf l-MetAsnProLysHis-5 35-ProSerAlaProTyrThrAspThrAsnGlyLeu-45 48-AspTyrGlyAsnAlaSerAlaSerProTrpMetLysLysLeuGln-62 65-AlaGlnGlySerGlyGluThr-71 78-GlyAspSerHisThrAlaGlyAspPhePheThrAspSerLeuArgLysArgLeuGlnLysThrTrpGlyAspG lyGly-103 110-AlaAsnValLysGlyGlnArg-116 121-ArgHisAsnGlyAsnTrpGlnSerLeuThrSerArgAsnAsnThrGlyAspPheProLeu-140 157-AlaSerAspGlyIleAlaSerLysGlnArgVal-167 184-GlyAsnThrValSerAlaAsnGlyGlyGly-193 221-GluAsnProAlaGlyGly-226 241-GlnTrpSerLysTrpArgAlaAspArgMetAsnAspLeuAlaGlnThrGlyAla-258 266-GlyThrAsnGluAlaPheGlyAspAsnIleAspIleAlaAspThrGluGlnLysTrp-284 286-AspThrValArgGlnIleArgAspSerLeuPro-296 305-AlaProGluSerLeuLysAsnThr-312 319-ArgProValArgLeuThrGluValGlnGlnMetGlnArgArgIleAlaArgGlnGlyGlnThr-339 361-GlyTrpAlaAlaLysAspGlyVal-368 371-SerAlaLysGlyTyrGlnArgSerAlaGluMetLeuAlaAspSerLeuGluGluLeuValArg-391 393-AlaAlaIleArgGln-397 Hydrophilic Regions - Hopp-Woods 67-GlySerGlyGluThr-71 90-SerLeuArgLysArgLeuGlnLysThrTrpGly-100 112-ValLysGlyGlnArg-116 130-ThrSerArgAsnAsnThrGly-136 159-AspGlyIleAlaSerLysGlnArgVal-167 245-TrpArgAlaAspArgMetAsnAsp-252 270-AlaPheGlyAspAsnIleAspIleAlaAspThrGluGlnLysTrp-284 288-ValArgGlnIleArgAspSerLeuPro-296 319-ArgProValArgLeuThrGlu-325 327-GlnGlnMetGlnArgArgIleAlaArgGlnGly-337 363-AlaAlaLysAspGlyVal-368 374-GlyTyrGlnArgSerAlaGluMetLeuAlaAspSerLeuGluGluLeuValArg-391 393-AlaAlaIleArgGln-397 a302 AMPHI Regions - AMPHI 20-AspGlyArgPheLeuArgThrValGluTrpLeuGlyAsnMetLeuProHisPro-37 81-ValValSerLeuLeuAspAlaAspGlyLeuIleLysIleLeuThrHisThrValLysAsnPheThrGlyPheA laProLeuGlyThrValLeuValSerLeu-114 127-SerAlaLeuMetArg-131 176-GlyArgHisProLeuAlaGlyLeuAlaAlaAlaPheAlaGlyValSerGly-192 201-GlyThrIleAspProLeuLeuAlaGlyIleThrGlnGlnAla-214 239-ValIleAlaLeuIleGly-244 271-ArgHisSerAsnGluIle-276 294-LeuSerAlaLeuLeuAlaTrp-300 308-IleLeuArgHisProGluThrGly-315 341-TyrGlyArgValThrArgSerLeuArgGlyGluGlnGluValValAsnAlaMetAlaGluSerMetSer-36 3 378-PheValAlaPhePheAsnTrpThrAsnIleGlyGlnTyrIle-391 448-AlaProGluValIleGlnAlaAlaTyrArgIleGlyAspSerValThrAsnIleIleThrProMetMetSer TyrPheGlyLeuIleMetAla-478 505-IleAlaTrpIleAlaLeuPheCysIle-513 Antigenic Index - Jameson-Wolf 8-LysGluLysGlnMetSerGlnThrAspThrGlnArgAspGlyArgPhe-23 61-SerValProAspProArgProValGlyAlaLysGlyArgAlaAspAspGlyLeu-78 85-LeuAspAlaAspGlyLeu-90 119-IleAlaGluLysSerGly-124 134-LeuThrLysSerProArgLysLeuThr-142 152-LeuSerAsnThrAlaSerGlu-158 175-LeuGlyArgHisProLeu-180 250-LysIleValGluProGlnLeuGlyProTyrGlnSerAspLeuSerGlnGluGluLysAspIleArgHisSer AsnGluIleThrProLeuGluTyrLys-282 304-ProAlaAspGlyIleLeuArgHisProGluThrGlyLeuValSer-318 343-ArgValThrArgSerLeuArgGlyGluGlnGluVal-354 402-ValGlyLeuGlyGly-406 482-LysTyrLysLysAspAlaGlyVal-489 Hydrophilic Regions - Hopp-Woods 8-LysGluLysGlnMetSerGlnThrAspThrGlnArgAspGlyArgPhe-23 63-ProAspProArgProValGlyAlaLysGlyArgAlaAspAspGlyLeu-78 85-LeuAspAlaAspGlyLeu-90 119-IleAlaGluLysSerGly-124 136-LysSerProArgLysLeu-141 263-LeuSerGlnGluGluLysAspIleArgHisSerAsnGlu-275 307-GlyIleLeuArgHisProGlu-313 343-ArgValThrArgSerLeuArgGlyGluGlnGluVal-354 482-LysTyrLysLysAspAlaGly-488 a305 AMPHI Regions - AMPHI 10-LeuMetMetGlyLeuValGluGlyPheThrGluPheLeuPro-23 33-PheGlyAsnLeuIleAspPheHisSer-41 66-PheSerAsnValLeuHis-71 93-AlaAlaValMetGly-97 99-LeuPheGlyLysGlnlleLysGluTyrLeuPhe-109 141-AspValAspAlaLeuArgProIleAspAla-150 155-ValAlaGlnValPheAla-160 202-AlaTyrAspValLeuLysHisTyrArgPhePheThrLeuHis-215 222-IleGlyPheValAlaAlaPheValSer-230 235-ValLysAlaLeuLeuArg-240 Antigenic Index - Jameson-Wolf 40-HisSerAsnHisLys-44 61-GluTyrArgGlnArgPheSerAsn-68 72-GlyValGlyLysAspArgLysAlaAsn-80 128-ValGluLysArgGlnSerArgAlaGluProLysIleValAsp-141 143-AspAlaLeuArgProIleAsp-149 163-ProGlyThrSerArgSerGlySer-170 180-IleGluArgLysThrAlaThr-186 241-PheValSerLysLysAsnTyr-247 Hydrophilic Regions - Hopp-Woods 62-TyrArgGlnArgPhe-66 73-ValGlyLysAspArgLysAlaAsn-80 128-ValGluLysArgGlnSerArgAlaGluProLysIleValAsp-141 143-AspAlaLeuArgProIleAsp-149 165-ThrSerArgSerGlySer-170 180-IleGluArgLysThrAlaThr-186 242-ValSerLysLysAsn-246 a308-2 AMPHI Regions - AMPHI 6-PheTyrArgIleLeuGlyValAlaAspAsnLeuTyrProTyrLeu-20 27-ThrIleIleAlaGlyLeu-32 64-AlaLeuGluLeuLeuArgAlaGlnAsp-72 83-AlaGluMetAlaArgAlaSerGlu-90 101-LeuAlaAspPheValHisProIleGlyAsnIleGlyAlaCys-114 131-SerMetArgThrLeuAlaSerValValHisGlyPheGlyAsp-144 172-LeuAlaHisLeuAspAsnMetLysArgValThrGlu-183 Antigenic Index - Jameson-Wolf 39-TrpGluArgArgMetMetVa1-45 68-LeuArgAlaGlnAspIleGluThr-75 80-SerLysGlyAlaGluMetAlaArgAlaSerGluThrAlaTyrAlaArgAspGluVal-98 118-GlyThrPheLysThrAspGlyMet-125 142-PheGlyAspAsnLeuLeu-147 149-ArgAlaAlaAspValValLeuLysGluArgArgArgLeu-161 166-ArgGluThrProLeu-170 176-AspAsnMetLysArgValThrGluMetGly-185 195-MetTyrArgLysProGlnThrAlaAspAspIleVal-206 219-IleAspThrProAspSerAlaGlu-226 Hydrophilic Regions - Hopp-Woods 39-TrpGluArgArgMetMetVal-45 68-LeuArgAlaGlnAspIleGluThr-75 81-LysGlyAlaGluMetAlaArgAlaSerGlu-90 92-AlaTyrAlaArgAspGluVal-98 120-PheLysThrAspGly-124 149-ArgAlaAlaAspValValLeuLysGluArgArgArgLeu-161 176-AspAsnMetLysArgValThrGlu-183 195-MetTyrArgLysProGlnThrAlaAspAspIleVal-206 220-AspThrProAspSerAlaGlu-226 a311-l AMPHI Regions - AMPHI 7-SerHisTrpArgValLeuAlaGluLeuAlaAspGlyLeuProGlnHisValSerGlnLeuAlaArgMetAlaAs p-31 37-LeuAsnGlyPheTrpGlnGlnMetProAlaHisIleArgGlyLeuLeuArg-53 55-HisAspGlyTyrTrpArgLeuValArgProLeuAlaValPheAspAlaGluGlyLeuArgGluLeuGly-77 124-ArgGlnGlyArgLysTrpSerHisArgLeu-133 165-ArgAlaLeuSerArgLeu-170 219-ValGluAsnAlaAlaSerValGlnSerLeuPheGln-230 245-GluThrLeuLeuAlaGlu-250 291-PheGluGlyThrValLysGlyValAspGlyGlnGlyVal-303 362-ThrValGlySerAlaProTyrArgAspLeuSerProLeu-374 376-AlaGluTrpAlaGluLysVal-382 391-CysAlaValCysGlyGluPheLysLys-399 426-TyrArgHisProGluGluHisGlySerAspArgTrpPheAsnAlaLeuGlySer-443 493-AsnLeuAsnArgHisAla-498 511-AlaValAlaSerGlyMetMetAspAlaValCys-521 550-AlaAlaLysValAlaGluAlaLeuProPro-559 576-HisGlyLeuLeuAsnLeu-581 Antigenic Index - Jameson-Wolf 28-ArgMetAlaAspMetLysProGlnGln-36 50-GlyLeuLeuArgGlnHisAspGlyTyr-58 71-GluGlyLeuArgGluLeuGlyGluArgSerGlyPhe-82 86-LeuLysHisGluCysAlaSerSerAsnAspGluIleLeuGlu-99 102-ArglleAlaProAspLysAlaHisLys-110 116-HisLeuGlnSerLysGlyArgGlyArgGlnGlyArgLysTrpSerHisArgLeuGlyGlu-135 145-PheAspArgProGlnTyrGluLeuGlySer-154 162-AlaCysArgArgAlaLeuSer-168 174-ThrGlnIleLysTrpProAsn-180 182-LeuValValGlyArgAspLysLeuGly-190 196-ThrValArgThrGlyGlyLysThrVal-204 215-LeuProLysGluValGluAsn-221 231-ThrAlaSerArgArgGlyAsnAlaAsp-239 258-TyrAlaArgAspGlyPheAla-264 272-AlaAlaAsnArgAspHisGlyLys-279 284-LeuArgAspGlyGluThrValPhe-291 293-GlyThrValLysGlyValAspGlyGlnGly-302 307-GluThrAlaGluGlyLysGlnThrValValSerGlyGluIleSerLeuArgSerAspAspArgProValSer ValProLysArgArgAspSerGluArg-339 344-AspGlyGlyAsnSerArgLeu-350 364-GlySerAlaProTyrArgAspLeuSerProLeuGly-375 378-TrpAlaGluLysValAspGlyAsnValArgIle-388 395-GlyGluPheLysLysAlaGlnValGln-403 405-GlnLeuAlaArgLysIleGlu-411 424-AsnHisTyrArgHisProGluGluHisGlySerAspArgTrp-437 440-AlaLeuGlySerArgArgPheSerArgAsnAla-450 464-AlaLeuThrAspAspGlyHisTyrLeuGly-473 483-MetLysGluSerLeuAla-488 492-AlaAsnLeuAsnArgHisAlaGlyLysArgTyrPro-503 529-GlyArgLeuLysGluLysThrGlyAlaGlyLysProVal-541 547-GlyGlyGlyAlaAlaLysValAlaGlu-555 565-AsnThrValArgValAlaAsp-571 584-AlaGluGlyGlyGluSerGluHisThr-592 Hydrophilic Regions - Hopp-Woods 28-ArgMetAlaAspMetLysProGlnGln-36 50-GlyLeuLeuArgGlnHis-55 71-GluGlyLeuArgGluLeuGlyGluArgSerGlyPhe-82 86-LeuLysHisGluCysAlaSerSerAsnAspGluIleLeuGlu-99 102-Argl1eAlaProAspLysAlaHisLys-110 118-GlnSerLysGlyArgGlyArgGlnGlyArgLysTrpSerHisArgLeuGlyGlu-135 162-AlaCysArgArgAlaLeuSer-168 183-ValValGlyArgAspLysLeuGly-190 196-ThrValArgThrGlyGlyLys-202 217-LysGluValGluAsn-221 232-AlaSerArgArgGlyAsnAlaAsp-239 259-AlaArgAspGlyPhe-263 272-AlaAlaAsnArgAspHisGlyLys-279 285-ArgAspGlyGluThrValPhe-291 293-GlyThrValLysGlyValAspGly-300 307-GluThrAlaGluGlyLysGlnThrValVal-316 320-IleSerLeuArgSerAspAspArgProValSerValProLysArgArgAspSerGluArg-339 346-GlyAsnSerArgLeu-350 367-ProTyrArgAspLeuSer-372 378-TrpAlaGluLysValAspGlyAsnVal-386 395-GlyGluPheLysLysAlaGlnVal-402 405-GlnLeuAlaArgLysIleGlu-411 424-AsnHisTyrArgHisProGluGluHisGlySer-434 442-GlySerArgArgPheSerArg-448 464-AlaLeuThrAspAspGlyHis-470 483-MetLysGluSerLeuAla-488 493-AsnLeuAsnArgHisAlaGlyLysArgTyrPro-503 529-GlyArgLeuLysGluLysThrGlyAlaGlyLysProVal-541 549-GlyAlaAlaLysValAlaGlu-555 565-AsnThrValArgValAlaAsp-571 585-GluGlyGlyGluSerGluHisThr-592 a312 AMPHI Regions - AMPHI 6-GlyGluIleLeuGluThrValLysMetValAla-16 44-GlnAsnIleTyrAsnLysIleThrThrValGlyLys-55 82-IleAlaGlnIleAlaAlaAlaThr-89 95-ValSerValAlaGlnThrLeuAspLysAlaAlaLys-106 109-GlyValSerPheIleGlyGlyPheSerAlaLeuValGln-121 133-ArgSerIleProGluAlaMetLysThr-141 167-GlyGluThrIleLysArgThr-173 182-GlyCysAlaLysIleValValPheCys-190 230-SerAspAlaThrThrLeuThrGluValAlaGluValValLysLys-244 249-IleThrArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 281-ValGlyAspSerValAlaArgIleLeuGluGluMetGly-293 309-LeuAsnAspAlaVal-313 322-SerAlaValGlyGlyLeuSerGly-329 349-LeuThrLeuAspLysLeuGluAlaMetThrAla-359 374-ThrProAlaHisThrIleSerGlyIleIle-383 409-ValGlyAspSerValGluPheGlyGlyLeuLeuGly-420 Antigenic Index - Jameson-Wolf 4-GlnSerGlyGluIleLeuGlu-10 13-LysMetValAlaAspGlnAsnPheAspVal-22 35-IleSerThrAspIleAspVal-41 52-ThrValGlyLysAspLeuValAla-59 89-ThrHisAlaAspSer-93 100-ThrLeuAspLysAlaAlaLys-106 121-GlnLysGlyMetSerProSerAspGluValLeu-131 134-SerIleProGluAlaMetLysThrThrAsp-143 152-GlySerThrArgAla-156 161-AspAlaValArgLeuAlaGlyGluThrIleLysArgThrAlaGluIleThr-177 192-AlaValGluAspAsnProPhe-198 204-HisGlySerGlyGluAlaAspAla-211 225-AlaAlaLeuGluAsnSerAspAla-232 237-GluValAlaGluValValLys-243 251-ArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 280-AlaValGlyAspSerValAlaArgIleLeuGlu-290 311-AspAlaValLysLysGlyGlyMet-318 334-ValSerGluAspGluGlyMet-340 352-AspLysLeuGluAla-356 37O-ValProGlyAspThrProAla-376 383-IleAlaAspGluAlaAla-388 392-IleAsnSerLysThrThrAla-398 405-ThrGlyLysThrValGlyAspSerValGlu-414 426-ProValLysGluGlySerCys-432 435-PheValAsnArgGlyGlyArgIle-442 447-GlnSerMetLysAsn-451 Hydrophilic Regions - Hopp-Woods 18-GlnAsnPheAspVal-22 35-IleSerThrAspIleAspVal-41 52-ThrValGlyLysAspLeuValAla-59 100-ThrLeuAspLysAlaAlaLys-106 123-GlyMetSerProSerAspGluValLeu-131 134-SerIleProGluAlaMetLysThrThrAsp-143 161-AspAlaValArgLeuAlaGlyGluThrIleLysArgThrAlaGluIleThr-177 192-AlaValGluAspAsnPro-197 207-GlyGluAlaAspAla-211 225-AlaAlaLeuGluAsnSerAspAla-232 237-GluValAlaGluValValLys-243 251-ArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 284-SerValAlaArgIleLeuGlu-290 311-AspAlaValLysLysGlyGlyMet-318 334-ValSerGluAspGluGlyMet-340 352-AspLysLeuGluAla-356 383-IleAlaAspGluAlaAla-388 408-ThrValGlyAspSerValGlu-414 426-ProValLysGluGlySerCys-432 438-ArgGlyGlyArgIle-442 447-GlnSerMetLysAsn-451 a313-2 AMPHI Regions - AMPHI 27-GlyMetAspAspProArgThrTyrGlySerGly-37 41-AlaThrAsnValLeu-45 60-AspAlaAlaLysGly-64 66-ValAlaValLeuLeuAlaArgValLeuGlnGluPro-77 88-ValAlaLeuAlaAlaLeuValGlyHisMetTrpPro-99 143-SerLeuAlaAlaLeuThrAlaThrIleAlaAlaProLeuAlaAla-157 Antigenic Index - Jameson-Wolf 26-TyrGlyMetAspAspProArgThrTyrGlySerGlyAsnProGlyAla-41 46-ArgSerGlyLysLysLysAlaAla-53 73-ValLeuGlnGluProLeuGlyLeuSerAspSerAla-84 104-PheLysGlyGlyLysGlyVal-110 180-ArgHisLysSerAsn-184 189-IleLysGlyLysGluSerLysIleGlyGluLysArg-200 Hydrophilic Regions - Hopp-Woods 26-TyrGlyMetAspAspProArgThrTyrGly-35 46-ArgSerGlyLysLysLysAlaAla-53 105-LysGlyGlyLysGlyVal-llO 189-IleLysGlyLysGluSerLysIleGlyGluLysArg-200 a401 AMPHI Regions - AMPHI 44-SerGlyValLysProTyrAsnAlaLeu-52 65-CysTyrAsnCysHisSerGlnMetIleArgProPheArg-77 112-ValGlyGlyArgTyrSerAspGluTrpHisArgIle-123 157-MetLysAlaLeuArgLysValGlyThr-165 172-IleAlaLysAlaProGluAlaLeu-179 Antigenic Index - Jameson-Wolf 5-GlnLeuAlaGluGluLysIle-ll 38-AlaAlaThrGlnProAlaSerGlyValLysProTyrAsn-50 55-AlaGlyArgAspIleTyrIleArgGluGlyCysTyrAsnCysHis-69 74-ArgProPheArgAlaGluThrGluArgTyrGlyHis-85 90-GlyGluSerValTyr-94 98-PheGlnTrpGlySerLysArgThrGlyProAspLeuAlaArgValGlyGlyArgTyrSerAspGluTrpHis- 121 125-LeuLeuAsnProArgAspValValProGluSerAsnMetPro-138 146-AsnLysValAspValAspAla-152 158-LysAlaLeuArgLysValGlyThrProTyrSerAspGluGluIleAlaLysAlaProGlu-177 179-LeuAlaAsnLysSerGluLeuAspAla-187 Hydrophilic Regions - Hopp-Woods 5-GlnLeuAlaGluGluLysIle-ll 76-PheArgAlaGluThrGluArgTyrGly-84 101-GlySerLysArgThrGlyProAspLeuAlaArgValGlyGlyArgTyrSerAspGluTrpHis-121 127-AsnProArgAspValValPro-133 146-AsnLysValAspValAspAla-152 158-LysAlaLeuArgLysValGly-164 167-TyrSerAspGluGluIleAlaLysAlaProGlu-177 179-LeuAlaAsnLysSerGluLeuAspAla-187 a402 AMPHI Regions - AMPHI 18-PheLeuSerGlyLeu-22 85-AlaGlyIleAlaAspPhe-90 100-ThrGlyPheSerGlyPheValHis-107 117-AlaValValArgGlyLeu-122 136-LysSerGlyArgGln-140 146-PheAlaAsnValAlaGly-151 218-ValPheGlnAsnIleAlaAspArgProAspArgLeuIle-230 261-AspValPheAsnSerValAsnGlyIleGlu-270 279-LysSerGlyIleArg-283 294-SerTrpAlaArgValLeuSerAlaIleProGluMetGln-306 344-ArgLysTrpLeuArgArgHisPro-351 376-AlaGluPheLeuLysGlnValGlnSerHisLeu-386 398-HisSerProHisAlaPheAlaThrAlaValHisSerIlePro-411 437-GlnArgLeuSerArgLeu-442 460-AlaAlaGlnLysVal-464 Antigenic Index - Jameson-Wolf 4-ValAsnThrLysProAsnThrΞer-ll 66-ArgIleCysArgSerArgPheValAsp-74 130-ValGlyThrAspGlyAsnLysSerGlyArgGlnValSer-142 222-IleAlaAspArgProAspArgLeuIleGluAsnLysHisGly-235 240-TyrHisArgAspGlyAspLysValVal-248 264-AsnSerValAsnGlyIleGluArg-271 277-SerLeuLysSerGlyIleArgArg-284 321-IleAlaAspGluProGln-326 331-LeuGlnAspLysArgValGluIleValLeuAspAspGlyArgLysTrpLeuArgArgHisProAspGluLys PheAsp-356 385-HisLeuThrProAspGly-390 429-PheProAsnLysGluLeuLeuLysGlnArgLeuSer-440 444-TrpProGluSerGlyArgHisValPheAspSerSerThrVal-457 472-MetThrGluProSerAlaGly-478 481-ValIleThrAspAspAsnMet-487 489-ValGluTyrLysTyrGlyArgGlyIle-497 Hydrophilic Regions - Hopp-Woods 131-GlyThrAspGlyAsnLysSerGlyArgGlnVal-141 222-11eAlaAspArgProAspArgLeuIleGluAsnLysHis-234 241-HisArgAspGlyAspLysValVal-248 278-LeuLysSerGlyIleArg-283 321-IleAlaAspGluProGln-326 331-LeuGlnAspLysArgValGluIleValLeuAspAspGlyArgLysTrpLeuArgArgHisProAspGluLys PheAsp-356 430-ProAsnLysGluLeuLeuLysGlnArgLeuSer-440 446-GluSerGlyArgHisValPhe-452 473-ThrGluProSerAlaGly-478 481-ValIleThrAspAspAsnMet-487 a501 AMPHI Regions - AMPHI 63-ValGluValLeuGlnGluLeuPheArgGlnTyrArgValAlaArgGlnLeu-79 88-ValPheAlaAlaPheGlnAlaVal-95 97-PheGlnGlyPheAspAsnGlyPhe-104 126-AlaAspAlaPheGlnGly-131 139-ValPheGluValValGlyAspIleThrArgArgThrThrGluAla-153 183-AspGlyPheThrArgIleAsnArgCysGlyGlnCys-194 196-HisAlaPheGlyAspPheIleAsp-203 252-AlaPheAlaGlyGlnVal-257 270-HisHisAspPheTyrArgCysPheArgHisValValGlnSerAsnIleGlyAsnLeu-288 306-TyrGlyAsnPheLeuThrValPheGlnGlnPheGlyCys-318 364-GlyAsnGlnTyrValAlaGlyPhe-371 438-AlaSerProPheAsp-442 458-ArgGlnLeuGlyAspPhe-463 511-PheGlnArgGlyPheGluHisIleGlu-519 528-TyrAspValPheAlaGln-533 Antigenic Index - Jameson-Wolf 6-LeuThrAlaAspAla-10 17-AlaAlaGlyGlyAspGlyLysVal-24 26-HisHisPheAspGly-30 46-ValGluThrGluGlyGln-51 56-ValArgAlaAspGlyGluAlaValGluVal-65 100-PheAspAsnGlyPhe-104 108-GlnSerAlaAspGluArgAsnHisAspPheAsnValGlyGln-121 144-GlyAspI1eThrArgArgThrThrGluAlaGlnHis-155 179-GlyHisThrAspAspGlyPheThrArgl1eAsnArgCysGlyGlnCys-194 202-IleAspValGluValAspArgGlyArgValThrGlyAspThrAlaGlyAsnPhe-219 230-GlnGlnGlyPheGlyValAspThrAspLeuAlaValAspAspLysPheHisThrArgGlnAlaAsp-251 257-ValGlyGluAlaGluCysGluPheGly-265 269-ValHisHisAspPheTyrArgCys-276 294-GlyValAspGluAlaGly-299 320-AlaAlaAlaAspAsnGlyArgAsnThrGlnPheAlaArgAspAspGlyGlyValAlaGlyThrSerAlaPro ValGlyHisAspGlyGlySer-350 405-ValAspArgLysAlaAla-410 420-PheAspGlyPheGlyThrGlyLeuGlnAsp-429 439-SerProPheAspValHisArg-445 477-AspIleAspValGlyTyr-482 490-ValGlyLysAsnHisPheAsp-496 502-PheAlaGlnAspGlyArgPhe-508 512-GlnArgGlyPheGluHis-517 535-ValGlySerAspLysAspAspLeuVal-543 548-GlyIleGluGlyGluHisHisThr-555 Hydrophilic Regions - Hopp-Woods 6-LeuThrAlaAspAla-10 19-GlyGlyAspGlyLysVal-24 46-ValGluThrGluGlyGln-51 56-ValArgAlaAspGlyGluAlaValGluVal-65 108-GlnSerAlaAspGluArgAsnHisAsp-116 144-GlyAspIleThrArgArgThrThrGluAlaGlnHis-155 179-GlyHisThrAspAspGlyPheThrArgIleAsnArg-190 202-IleAspValGluValAspArgGlyArgValThrGlyAspThr-215 237-ThrAspLeuAlaValAspAspLysPheHisThrArgGlnAlaAsp-251 257-ValGlyGluAlaGluCysGluPheGly-265 294-GlyValAspGluAlaGly-299 323-AspAsnGlyArgAsnThrGlnPheAlaArgAspAspGlyGlyVal-337 344-ValGlyHisAspGly-348 405-ValAspArgLysAlaAla-410 535-ValGlySerAspLysAspAspLeuVal-543 549-IleGluGlyGluHisHisThr-555 a502-l AMPHI Regions - AMPHI 6-AsnLeuPheGlnPheLeuAlaVal-13 26-GlyAlaValAspAlaLeuLysGlnPheAsnAsnAspAlaAspGlyIleSerGlySerPheThrGln-47 98-GlnValThrLysSerΞerGlnAsp-105 Antigenic Index - Jameson-Wolf 32-LysGlnPheAsnAsnAspAlaAspGlyIleSerGlySer-44 48-ThrValGlnSerLysLysLysThrGlnThrAlaHisGlyThr-61 74-TyrThrSerProTyrLysGlnThrIle-82 98-GlnValThrLysSerSerGlnAspGlnAlaIleGlyGlySerPro-112 116-LeuSerAsnLysThrAlaLeuGluSerSerTyrThrLeuLysGluAspGlySerSerAsnGly-136 142-AlaThrProLysArgAsnAsnAlaGly-150 158-PheLysGlyGlyAsn-162 167-GlnLeuLysAspSerPheGlyAsnGlnThr-176 184-AsnThrAsnProGlnLeuSerArgGlyAlaPhe-194 196-PheThrProProLysGlyValAspVal-204 Hydrophilic Regions - Hopp-Woods 34-PheAsnAsnAspAlaAspGlyIle-41 49-ValGlnSerLysLysLysThrGlnThr-57 100-ThrLysSerSerGlnAspGlnAlaIle-108 126-TyrThrLeuLysGluAspGlySerSerAsn-135 143-ThrProLysArgAsnAsnAla-149 167-GlnLeuLysAspSerPheGly-173 a503-l AMPHI Regions - AMPHI 6-TyrArgGluAlaAsnThrTrp-12 96-SerSerThrSerAsnPheAlaSerAlaAlaGluMetArgSerLeu-110 Antigenic Index - Jameson-Wolf 4-SerLeuTyrArgGluAlaAsnThr-ll 26-ArgLysValSerCys-30 32-ProAlaAsnAspAlaSerGlyArgSerSerAlaValAlaGluGluArgThrAlaThrGluMetSerAlaProP roAla-57 69-SerAlaSerSerCysSerGlyLysGlyValSer-79 87-LeuProThrArgAlaSerSerAlaThrSerSerThrSerAsn-100 105-AlaGluMetArgSerLeuArg-111 113-LeuCysAlaArgAsnAlaArg-119 Hydrophilic Regions - Hopp-Woods 4-SerLeuTyrArgGlu-8 35-AspAlaSerGlyArgSerSerAlaValAlaGluGluArgThrAlaThrGluMetSerAla-54 73-CysSerGlyLysGlyValSer-79 89-ThrArgAlaSerSer-93 105-AlaGluMetArgSerLeuArg-lll a505 AMPHI Regions - AMPHI 20-LeuThrAlaLeuLeuLysCysLeuSerLeuLeuProLeuSerCysLeu-35 37-ThrLeuGlyAsnArg-41 89-ProAlaPhePheArgLysProGluAspIleGluThrMetPheLysAlaValHisGlyTrpGluHisValGlnG lnAlaLeuAsp-116 148-AlaMetTyrLysProProLysIleLysAlaIleAspLysIleMetGlnAlaGly-165 178-IleGlnGlyValLysGlnIleIleLysAlaLeuArg-189 210-GlyValTrpValAspPhePheGlyLysPro-219 Antigenic Index - Jameson-Wolf 38-LeuGlyAsnArgLeuGly-43 50-LeuLysGluAspArgAlaArgIle-57 62-ArgGlnAlaGlyMetAsnProAspProLysThrVal-73 79-GluThrAlaLysGlyGlyLeu-85 92-PheArgLysProGluAspIleGluThr-100 114-AlaLeuAspLysHisGlu-119 129-GlySerTyrAspLeuGlyGlyArgTyrIleSer-139 142-LeuProPheProLeu-146 150-TyrLysProProLysIleLysAlaIleAspLysIleMetGln-163 165-GlyArgValArgGlyLysGlyLysThrAlaProThrSer-177 183-GlnIleIleLysAlaLeuArgSerGlyGluAlaThr-194 198-ProAspHisValProSerProGlnGluGlyGlyGluGlyVal-211 242-CysGluArgLeuProGlyGlyGlnGly-250 257-ProValGlnGlyGluLeuAsnGlyAspLysAlaHisAsp-269 292-TyrAsnArgTyrLysMetPro-298 Hydrophilic Regions - Hopp-Woods 50-LeuLysGluAspArgAlaArglle-57 62-ArgGlnAlaGlyMetAsnProAspProLysThrVal-73 79-GluThrAlaLysGlyGlyLeu-85 92-PheArgLysProGluAspIleGluThr-100 114-AlaLeuAspLysHisGlu-119 151-LysProProLysIleLysAlaIleAspLysIleMetGln-163 165-GlyArgValArgGlyLysGlyLysThrAlaPro-175 183-GlnIleIleLysAlaLeuArgSerGlyGlu-192 201-ValProSerProGlnGluGlyGlyGlu-209 258-ValGlnGlyGluLeuAsnGlyAspLysAlaHisAsp-269 a506 AMPHI Regions - AMPHI 6-GluValGlyArgValAlaHisCysGlyGlyGlyVal-17 25-ArgValValHisGlnValGluGlnGlyAlaArg-35 53-AlaValAspPheGlnArgArgPhe-60 99-AlaThrArgThrValAspArgAspLeuAlaGluVal-110 138-GlyAsnGluValAlaArgCys-144 180-GlnValLysArgMetIleArgHisPhePheArg-190 199-ValHisArgProPheArgLysLeuAlaAlaLeuAspGlyPheValGlnVal-215 224-GlyAspAspPheGlyGlyPhePheValGlyGlnValPheAsnAlaLeuLeu-240 313-PheValGlnValGlyGluLeuThrArgValAlaGlnGluGlu-326 372-GlyPhePheAlaAspPheAlaGluAspPheGlyAlaGlyValPheGlyAspValValArgTyrGlyLysArg Thr-396 408-PheGlyAspAspPheAlaHisGluValGlyGlu-418 427-ArgGlnGlnArgAlaAlaArgThr-434 Antigenic Index - Jameson-Wolf 13-CysGlyGlyGlyValAla-18 31-GluGlnGlyAlaArgLeu-36 48-ProValArgArgValAlaValAspPheGlnArgArgPheGlyGluVal-63 98-ArgAlaThrArgThrValAspArgAspLeuAlaGlu-109 134-GlyAlaAspThrGlyAsnGluValAlaArgCysGluGly-146 176-ProAsnPheGlyGlnValLysArgMetIle-185 192-GlyPheArgHisAspLeuAspValHisArgProPheArgLys-205 223-ValGlyAspAspPheGlyGly-229 244-MetGluPheHisProLysThr-250 259-ValGlyMetArgThrGluAla-265 289-GlyGlnGlnArgProGluValProVal-297 318-GluLeuThrArgValAlaGlnGluGluHisGlyArgValValAla-332 343-GluLeuGlnArgLysThrAlaAsp-350 362-CysHisGlyGlyGluThrGlyGlu-369 377-PheAlaGluAspPheGly-382 389-ValValArgTyrGlyLysArgThrGluArgAlaArgThr-401 408-PheGlyAspAspPheAlaHisGluVal-416 424-GlnIleLeuArgGlnGlnArgAlaAlaArgThrGlyGlyGln-437 442-ValGlyAsnArgArgAlaVal-448 458-PheGlyGlyXxxHisArgSerCysSer-466 471-GlyGlnXxxGlyGlyLysArgLeuThrValArgPheGlyGlyLysArgIleArgAsnArgPheLeuAspCys AsnLysPheLeuGlu-499 510-MetAspAlaThrIleArgGlnAspPheArgTyr-520 Hydrophilic Regions - Hopp-Woods 31-GluGlnGlyAlaArgLeu-36 48-ProValArgArgValAlaValAspPheGlnArgArgPheGlyGlu-62 98-ArgAlaThrArgThrValAspArgAspLeuAlaGlu-109 136-AspThrGlyAsnGluValAlaArgCysGluGly-146 180-GlnValLysArgMetIle-185 195-HisAspLeuAspVal-199 201-ArgProPheArgLys-205 223-ValGlyAspAspPhe-227 244-MetGluPheHisPro-248 259-ValGlyMetArgThrGluAla-265 291-GlnArgProGluVal-295 318-GluLeuThrArgValAlaGlnGluGluHisGlyArgValValAla-332 343-GluLeuGlnArgLysThrAlaAsp-350 364-GlyGlyGluThrGlyGlu-369 377-PheAlaGluAspPheGly-382 390-ValArgTyrGlyLysArgThrGluArgAlaArgThr-401 408-PheGlyAspAspPheAlaHisGluVal-416 425-IleLeuArgGlnGlnArgAlaAlaArgThrGlyGly-436 443-GlyAsnArgArgAlaVal-448 473-XxxGlyGlyLysArgLeuThr-479 482-PheGlyGlyLysArglleArgAsnArgPheLeuAsp-493 510-MetAspAlaThrIleArgGlnAspPheArgTyr-520 a513 AMPHI Regions - AMPHI 6-ThrGluTrpLeuHisGlyTrpValGlyAlalleAsnAspProMetTrp-21 23-TyrLeuValTyrXxxLeu-28 48-GlyArgSerIleLysGlu-53 66-GlyIleThrProPheGlnAlaPheValThrGlyLeuAla-78 119-SerSerLeuAlaGlnLeuPheLysValArgAsp-129 146-GlyLeuGlyGlnLysTrpLeuGlyVal-154 176-IleAlaAspThrVal-180 205-GlyGlyIleArgArgIleSerLysAlaAla-214 243-ValPheGlyGlnIlePheSer-249 259-GlyGlyLeuLeuGlyGlyLeuIle-266 288-AlaProAsnAlaAlaAlaAlaAla-295 303-GlnGlyMetIleGlnMetLeuGlyValPheValAsp-314 332-ProTyrGlyAspLeu-336 347-ValSerGlnValGlyGlnTrp-353 391-ThrAlaValPheArgMet-396 403-TyrPheGlyAlaValAla-408 423-IleMetAlaTrpIleAsnLeuValAlaIleLeuLeuLeuSer-436 Antigenic Index - Jameson-Wolf l-MetAsnGluAsnPhe-5 48-GlyArgSerIleLysGluMetLeuGlyGlyArgLysGlnGlyAspAspProHisGly-66 126-LysValArgAspTyrAspAsnHisHisPheArgGlyGlyProAla-140 208-ArgArgIleSerLysAlaAlaGlu-215 273-GlyIleLysArgGlyLeuTyrSerAsnGluAlaGlyMetGlySerAlaProAsnAla-291 295-AlaGluValLysHisProVal-301 331-GlnProTyrGlyAspLeuSerGly 375-AlaTyrAlaGluSerAsnVal-381 444-ArgAspTyrThrAlaLysLeuLysMetGlyLysAspProGluPheLysLeuSerGluHisProGlyLeuLys ArgArgIleLysSerAspValTrp-475 Hydrophilic Regions - Hopp-Woods 48-GlyArgSerIleLysGluMetLeuGlyGlyArgLysGlnGlyAspAspProHisGly-66 126-LysValArgAspTyrAspAsnHisHis-134 208-ArgArgIleSerLysAlaAlaGlu-215 273-GlyIleLysArgGlyLeuTyr-279 295-AlaGluValLysHis-299 450-LeuLysMetGlyLysAspProGluPheLysLeuSerGlu-462 464-ProGlyLeuLysArgArgIleLysSer-472 a515-l AMPHI Regions - AMPHI 8-ArgAlaAlaGlyValAlaArgGlyLeuHisSerGluPheAlaArg-22 59-AspValArgPhePheAlaGlnValGluGluIleGlyGlnAspPhePheAlaAspAla-77 90-AlaGlyGluCysAlaAspGluValSerAspLysThr-101 122-GluSerAlaGlnSerAlaAlaGlyGlyGlyLeuThrAspGlyPheGly-137 176-CysGlyLysThrValGlyVal-182 198-GlyValPheAspAla-202 233-ValAlaAspValLeuArg-238 251-PheGlyGlyValAlaGlyAspValGlyGlyGlyAlaAspGlyValAlaGlnGlyLeuPheGlyGluIleGly GlyAla-276 Antigenic Index - Jameson-Wolf 24-ValThrAlaGluGluIleAlaPhe-31 38-HisGluAlaArgCysGlyGlyAsn-45 51-IleAlaAlaAlaGluArgAlaGlyAsp-59 67-GluGluIleGlyGln-71 77-AlaValAspGlnGluThr-82 84-LeuAlaValGluArgSerAlaGlyGluCysAlaAspGluValSerAspLysThrAlaArgAsnGlyGlyIleG luGluAspGlyValValAlaCysArgAspAlaAlaAlaAlaGluSerAlaGln-125 128-AlaGlyGlyGlyLeuThrAspGly-135 160-GlyGlyAsnAspAlaAlaGlyAsn-167 192-LeuHisArgArgAla-196 217-AlaAspGlyGlyPheArg-222 242-GlyValGlyLysSerGlyAla-248 257-AspValGlyGlyGlyAlaAspGlyVal-265 284-AspValAsnGlyAsnValGln-290 Hydrophilic Regions - Hopp-Woods 24-ValThrAlaGluGluIleAlaPhe-31 38-HisGluAlaArgCysGly-43 51-IleAlaAlaAlaGluArgAlaGlyAsp-59 77-AlaValAspGlnGluThr-82 84-LeuAlaValGluArgSerAlaGlyGluCysAlaAspGluValSerAspLysThrAlaArgAsnGlyGlyIleG luGluAspGlyValValAlaCysArgAspAlaAlaAlaAlaGluSerAlaGln-125 162-AsnAspAlaAlaGly-166 192-LeuHisArgArgAla-196 258-ValGlyGlyGlyAlaAspGlyVal-265 a519-l AMPHI Regions - AMPHI 29-ValValGluArgLeuGlyArgPheHisArgAlaLeuThrAlaGly-43 105-MetAlaIleThrGlnLeuAlaGlnThrThrLeuArgSerVal-118 139-ValSerAlaLeuAspGluAlaAla-146 166-GluIleLeuArgSerMetGlnAla-173 192-LysIleGluGlnIle-196 221-SerAsnAlaGluLysIleAlaArgIleAsn-230 249-AlaIleArgGlnIleAlaAlaAla-256 273-GlnTyrValAlaAlaPheAsnAsnLeuAlaLys-283 292-AlaAsnValAlaAspIleGlySerLeuIleSerAlaGlyMetLysIleIleAspSerSerLysThrAla-31 4 Antigenic Index - Jameson-Wolf 31-GluArgLeuGlyArgPheHisArg-38 58-HisSerLeuLysGluIleProLeuAspValProSerGln-70 72-Cys11eThrArgAspAsnThrGInLeuThrVal-82 91-ThrAspProLysLeuAlaSer-97 122-MetGluLeuAspLysThrPheGluGluArgAspGluIleAsn-135 141-AlaLeuAspGluAlaAlaGly-147 154-LeuArgTyrGluIleLysAspLeuValPro-163 175-IleThrAlaGluArgGluLysArgAlaArgIleAlaGluSerGluGlyArgLysIleGluGln-195 197-AsnLeuAlaSerGlyGlnArgGluAlaGluIleGlnGlnSerGluGlyGluAlaGlnAla-216 219-AsnAlaSerAsnAlaGluLysIleAlaArgIleAsnArgAlaLysGlyGluAlaGluSerLeuArgLeu-24 1 245-AlaAsnAlaGluAlaIleArg-251 258-GlnThrGlnGlyGlyAlaAspAlaValAsn-267 281-LeuAlaLysGluSerAsnThr-287 303-AlaGlyMetLysIleIleAspSerSerLysThrAlaLys-315 Hydrophilic Regions - Hopp-Woods 31-GluArgLeuGlyArgPheHisArg-38 58-HisSerLeuLysGluIleProLeu-65 73-11eThrArgAspAsnThr-78 91-ThrAspProLysLeu-95 122-MetGluLeuAspLysThrPheGluGluArgAspGluIleAsn-135 141-AlaLeuAspGluAlaAla-146 154-LeuArgTyrGluIleLysAspLeuValPro-163 175-IleThrAlaGluArgGluLysArgAlaArgIleAlaGluSerGluGlyArgLysIleGluGln-195 200-SerGlyGlnArgGluAlaGluIleGlnGlnSerGluGlyGluAlaGlnAla-216 221-SerAsnAlaGluLysIleAlaArgIleAsnArgAlaLysGlyGluAlaGluSerLeuArgLeu-241 245-AlaAsnAlaGluAlaIleArg-251 281-LeuAlaLysGluSerAsn-286 306-LysIleIleAspSerSerLysThrAlaLys-315 a520-l AMPHI Regions - AMPHI 104-LeuThrLysAlaAlaAspGlyGlnValCysArgAlaPheSerSerLeu-119 Antigenic Index - Jameson-Wolf 20-LysProSerArgArgAlaLeu-26 47-AlaSerGlyLysIleSerLeuPro-54 84-ProProAsnAsnSerThrThrThrSerThrSerSerArgAlaThrSerSerAsnGlySerLeuThrLysAlaA laAspGlyGlnVal-112 117-SerSerLeuLysSerHisThrAlaGluIleArgIleSerArgProLysArgArgGluIleSerSerAlaLeu SerArgAsnThrAlaAla-146 150-ProThrValProLysProLysArgProMet-159 166-SerProCysLysProThrGluMet-173 Hydrophilic Regions - Hopp-Woods 20-LysProSerArgArgAlaLeu-26 93-ThrSerSerArgAlaThrSerSer-100 103-SerLeuThrLysAlaAlaAsp-109 120-LysSerHisThrAlaGluIleArgIleSerArgProLysArgArgGluIleSer-137 140-LeuSerArgAsnThrAla-145 151-ThrValProLysProLysArgProMet-159 168-CysLysProThrGluMet-173 a521 AMPHI Regions - AMPHI 86-ValLysThrValSerLysProAlaLys-94 133-GlnAlaArgLeuAlaLysGlyGlyAsn-141 147-IleAsnAlaLeuGlnSerValLeuAsp-155 Antigenic Index - Jameson-Wolf 1-MetLysSerLysLeu-5 36-ValTyrThrThrLysProSerLysSerCysLeuSerThrAspLeuProProIle-53 55-AsnTyrSerSerGluArgTyrIleProProGlnThrSerGluProThrProSerProSerAsnGlyGlyGln- 78 80-ValLysTyrLysAlaProVal-86 88-ThrValSerLysProAlaLysSerAsnThrProProProGlnGlnAlaProSerAsnAsnSerArgArgSerI leLeuGluThrGluLeuSerAsnGluArgLysAlaLeuValGluAlaGlnLysMetLeuSer-132 135-ArgLeuAlaLysGlyGlyAsnIleAsn-143 153-ValLeuAspArgGlnGlnAsn-159 163-LeuGlnArgGluLeuGlyArg-169 Hydrophilic Regions - Hopp-Woods 1-MetLysSerLysLeu-5 40-LysProSerLysSerCysLeu-46 57-SerSerGluArgTyrIle-62 65-GlnThrSerGluProThrProSerProSerAsnGly-76 80-ValLysTyrLysAlaProVal-86 88-ThrValSerLysProAlaLysSerAsnThrProPro-99 102-GlnAlaProSerAsnAsnSerArgArgSerIleLeuGluThrGluLeuSerAsnGluArgLysAlaLeuVal GluAlaGlnLysMetLeuSer-132 153-ValLeuAspArgGlnGlnAsn-159 163-LeuGlnArgGluLeuGlyArg-169 a522 AMPHI Regions - AMPHI 57-LysIleValGluSerCysValLys-64 96-MetTrpGluGlnProLeuAspArgLeuSerGluLysGlnIleSerSerPheGlyLysLeuGlyAlaGlnGluG lnLeuAspLeuLeuGlyGlyAla-127 Antigenic Index - Jameson-Wolf 1-MetThrGluProLysHisGluMetProThrGluGluGlnValAlaAlaArgLysLysAlaLysAlaLysIleAr gThr-26 48-AlaMetSerLysProGlnAlaLysGlnLysIleValGluSerCysValLys-64 71-LysTrpGlnAsnAspLeuArgAlaArgGlyLeuAspSerAsnAsnThrArgLeuThr-89 99-GlnProLeuAspArgLeuSerGluLysGlnIleSerSerPheGlyLysLeuGlyAla-117 128-AsnAlaPheGluThrArgAspLysGlnCysValAlaAspLeuLysSerGlu-144 Hydrophilic Regions - Hopp-Woods 1-MetThrGluProLysHisGluMetProThrGluGluGlnValAlaAlaArgLysLysAlaLysAlaLysIleAr gThr-26 48-AlaMetSerLysProGlnAlaLysGlnLysIleValGluSerCysVal-63 72-TrpGlnAsnAspLeuArgAlaArgGlyLeuAspSerAsnAsnThr-86 100-ProLeuAspArgLeuSerGluLysGlnIle-109 130-PheGluThrArgAspLysGlnCysValAlaAspLeuLysSerGlu-144 a525-l AMPHI Regions - AMPHI 59-GluPheAlaGluPheValAsnSerHisProGln-69 86-LysHisTrpMetLysAsnGly-92 125-ArgLeuProThrIleAspGluTrpGluPhe-134 166-AspLeuHisAspValGly-171 178-TrpGlyValTyrAsp-182 188-TrpGluTrpThrGlu-192 Antigenic Index - Jameson-Wolf 24-ValGlnIleGluGlyGlySerTyrArgProLeuTyrLeuLysLysAspThrGlyLeuIleLys-44 46-LysProPheLysLeuAspLysTyrProValThr-56 67-HisProGlnTrpGlnLysGlyArgIleGlySerLysGlnAlaGlu-81 88-TrpMetLysAsnGlySerArgSerTyrAlaProLysAlaGlyAspLeuLysGlnPro-106 122-GlnGlyLysArgLeuProThrIleAspGluTrpGlu-133 140-AlaThrGlnLysAsnGlySerAsnGluProGlyTyrAsnArgThr-154 159-TyrAlaAspGlyAspArgLysAspLeuHisAspValGlyLysGlyArgProAsnTyr-177 190-TrpThrGluAspPheAsnSerSerLeuLeuSerSerGlyAsnAla-204 213-AlaSerIleGlySerSerAspSerSerAsnTyr-223 234-SerLeuGlnSerLysTyr-239 Hydrophilic Regions - Hopp-Woods 35-TyrLeuLysLysAspThrGlyLeuIleLys-44 46-LysProPheLysLeuAspLysTyrPro-54 71-GlnLysGlyArgIleGlySerLysGlnAlaGlu-81 91-AsnGlySerArgSerTyrAla-97 99-LysAlaGlyAspLeuLysGln-105 122-GlnGlyLysArgLeuProThr-128 140-AlaThrGlnLysAsnGlySerAsnGluProGlyTyr-151 160-AlaAspGlyAspArgLysAspLeuHisAspValGlyLysGlyArgPro-175 216-GlySerSerAspSerSerAsn-222 a527 AMPHI Regions - AMPHI 7-PhePheGlnProValGln-12 28-SerAspAlaAlaGluLeuValGluLeuPheAlaLeuPhePro-41 73-GlyLysGlyIleGluArgGlnValAspAsnIleAlaAspValTyrGlyPhe-89 Antigenic Index - Jameson-Wolf 26-GlyGlySerAspAlaAlaGlu-32 52-GlnLysProArgLeuGlyCys-58 71-PheIleGlyLysGlyIleGluArgGlnValAspAsnIleAla-84 107-LeuLeuArgLysGlyThrGlyLeuGluLysThrCysArgProLysProPheValGlnProHisGlyGlyArg -130 Hydrophilic Regions - Hopp-Woods 27-GlySerAspAlaAlaGlu-32 52-GlnLysProArgLeuGlyCys-58 75-GlyIleGluArgGlnValAspAsnIleAla-84 107-LeuLeuArgLysGlyThrGlyLeuGluLysThrCysArgProLysPro-122 a528 AMPHI Regions - AMPHI 7-LysTyrThrAlaMetAlaAlaLeuLeuAlaPhe-17 23-ArgLeuAlaGlyTrpTyrGluCysSerSerLeuSerGlyTrpCysLysProArgLysProAlaAlaIle-45 69-AsnArgSerValArg-73 86-TyrArgLysIleGlyLysPhe-92 106-ProLeuIleGluThrPheLys-112 Antigenic Index - Jameson-Wolf l-MetGluIleArgAla-5 29-GluCysSerSerLeuSerGlyTrpCysLysProArgLysProAlaAla-44 49-AspIleGlyGlyGluSerProProSerLeuGluAspTyrGluIleProLeuSerAspGlyAsnArgSerValA rgAlaAsnGluTyrGluSerAlaGlnGlnSer-83 88-LysIleGlyLysPheGluAlaCysGlyLeuAspTrpArgThrArgAspGlyLysProLeu-107 110-ThrPheLysGlnGluGlyPheAspCysLeuLysLysGlnGlyLeuArgArgAsnGlyLeuSerGluArgVal ArgTrp-135 Hydrophilic Regions - Hopp-Woods l-MetGluIleArgAla-5 37-CysLysProArgLysProAlaAla-44 51-GlyGlyGluSerProProSerLeuGluAspTyrGluIleProLeu-65 67-AspGlyAsnArgSerValArgAlaAsnGluTyrGluSerAlaGln-81 88-LysIleGlyLysPheGluAlaCys-95 99-TrpArgThrArgAspGlyLysProLeu-107 111-PheLysGlnGluGlyPheAspCysLeuLysLysGlnGlyLeuArgArgAsnGlyLeuSerGluArgValArg Trp-135 a529 AMPHI Regions - AMPHI ll-LeuAlaLeuIleGlyLeuAlaAlaCysSer-20 35-SerHisArgLeuIle-39 49-AsnProAspGlnGlyAsnLeuTyrArgLeuProAla-60 79-GlnGlnProAlaAspAlaGluValLeuLysSerValLysGlyValArg-94 152-GlnAspSerLeuArgArgLeuPheAsp-160 162-ValGlyLeuGlyGlyIleTyr-168 196-AlaMetLysGluVal-200 223-AlaPheLeuThrArgPheMetGlnTyrLeu-232 252-AlaAsnGluMetAla-256 270-GlyArgAsnTrpArg-274 Antigenic Index - Jameson-Wolf 19-CysSerGlySerLysThrGluGlnProLysLeuAspTyrGlnSerArgSerHisArgLeuIleLys-40 42-GluValProProAspLeuAsnAsnProAspGlnGlyAsnLeuTyr-56 60-AlaGlySerGlyAlaValArgAlaSerAspLeuGluLysArgArgThrProAlaVal-78 80-GlnProAlaAspAlaGluValLeuLysSerValLysGlyValArgLeuGluArgAspGlySerGln-101 105-ValValAspGlyLysSerHisAla-112 123-GlnGluAsnGlyPheAspIleLysSerGluGluProAla-135 139-MetGluThrGluTrpAlaGluAsnArgAlaLysIleProGlnAspSerLeuArgArgLeuPhe-159 169-SerThrGlyGluArgAspLysPheIleValArgIleGluGlnGlyLysAsnGlyValSer-188 195-LysAlaMetLysGluValTyrGlyGlyLysAspLysAspThrThr-209 212-GlnProSerProSerAspProAsnLeu-220 233-GlyValAspGlyGlnGlnAlaGluAsnAlaSerAlaLysLysProThrLeu-249 253-AsnGluMetAlaArgIleGluGlyLysSer-262 268-AspTyrGlyArgAsnTrpArgArgThrAlaLeuAla-279 289-GlyGlnAsnThrGluArgHisAla-296 300-GlnLysAlaProAsnGluSerAsnAlaValThrGluGlnLysProGlyLeu-316 320-LeuLeuGlyLysGlyLysAlaGluLysProAlaGluGlnProGlu-334 342-ValAlaAsnGlySerArg-347 350-LeuLeuAsnLysAspGlySerAlaTyrAlaGlyLysAspAlaSer-364 370-LeuHisSerGluLeuArg-375 Hydrophilic Regions - Hopp-Woods 20-SerGlySerLysThrGluGlnProLysLeuAspTyrGlnSerArgSerHisArgLeuIleLys-40 42-GluValProProAspLeuAsnAsnProAspGln-52 63-GlyAlaValArgAlaSerAspLeuGluLysArgArgThrProAla-77 80-GlnProAlaAspAlaGluValLeuLysSerValLysGlyValArgLeuGluArgAspGlySerGln-101 107-AspGlyLysSerHisAla-112 125-AsnGlyPheAspIleLysSerGluGluProAla-135 139-MetGluThrGluTrpAlaGluAsnArgAlaLysIleProGlnAspSerLeuArgArgLeuPhe-159 170-ThrGlyGluArgAspLysPheIleVal-178 180-IleGluGlnGlyLysAsnGlyVal-187 195-LysAlaMetLysGluValTyrGlyGlyLysAspLysAspThrThr-209 214-SerProSerAspProAsnLeu-220 235-AspGlyGlnGlnAlaGluAsnAlaSerAlaLysLysProThr-248 253-AsnGluMetAlaArgIleGluGlyLysSer-262 269-TyrGlyArgAsnTrpArgArg-275 291-AsnThrGluArgHis-295 302-AlaProAsnGluSerAsnAlaValThrGluGlnLysProGlyLeu-316 320-LeuLeuGlyLysGlyLysAlaGluLysProAlaGluGlnProGlu-334 352-AsnLysAspGlySer-356 359-AlaGlyLysAspAlaSer-364 370-LeuHisSerGluLeuArg-375 a531 AMPHI Regions - AMPHI 59-SerLeuAlaGlyIleLeuAlaAspTyrValAlaGlyIleTrpGlyThr-74 90-GlySerIleIleGlyIlePhePheSerLeuProGlyLeuIleLeuGly-105 108-IleGlyAlaAlaAlaGly-113 131-ThrLeuLeuGlyLeuIleVal-137 Antigenic Index - Jameson-Wolf 74-ThrLysTyrThrGlyAlaGlyLysLeuAlaVal-84 114-GluLeuIleGluArgArgAsnMet-121 Hydrophilic Regions - Hopp-Woods 114-GluLeuIleGluArgArgAsnMet-121 a532 AMPHI Regions - AMPHI 6-GlyLysGlyAlaAsp-10 27-AlaLeuLeuSerAlaValThrHisLeuLeuAlaIlePheValProMetIleThr-44 76-TyrLeuGlnValAsnArgPheGlyPro-84 122-SerThrLeuLeuGly-126 147-LysValIleThrProThrVal-153 184-ThrPheGlySerMetGluAsnLeuGly-192 206-CysMetLysAsnPro-210 224-GlyTyrIleValAlaLeu-229 236-PheSerAlaLeuGlnAsnLeuPro-243 271-LeuSerValPheGluAlaValGlyAspLeuThrAla-282 297-ThrLysArgLeuArgGlyGlyVal-304 307-AspGlyLeuValSerValIleAlaThrAlaLeuGly-318 338-AlaSerArgHisValGlyLysTyr-345 361-ArgAlaPheThrThrIleProSerProVal-370 Antigenic Index - Jameson-Wolf l-MetSerGlyGlnLeuGlyLysGlyAlaAspAlaPro-12 18-LeuGluAspArgProProPheGlyAsn-26 80-AsnArgPheGlyPro-84 108-AlaGlyMetLysGluGlyGlyLeuThrLysAspAlaMet-120 177-PheGlyAlaLysAlaAspGlyThrPheGlySer-187 207-MetLysAsnProLeuLeuArg-213 286-ValSerAspGlnProIleGluGlyGluGluTyrThrLysArgLeuArgGlyGlyValLeu-305 391-ValSerHisGlyIleArgArgArgGluAlaVal-401 445-LeuProGluAspLysThrGluAlaAlaValLysPheAspThrAspHisLeuGluHis-463 Hydrophilic Regions - Hopp-Woods 4-GlnLeuGlyLysGlyAlaAspAlaPro-12 18-LeuGluAspArgProProPhe-24 109-GlyMetLysGluGlyGlyLeuThrLysAspAlaMet-120 179-AlaLysAlaAspGly-183 289-GlnProIleGluGlyGluGluTyrThrLysArgLeuArgGly-302 394-GlyIleArgArgArgGluAlaVal-401 445-LeuProGluAspLysThrGluAlaAlaValLysPheAspThrAspHisLeuGluHis-463 a537 AMPHI Regions - AMPHI 38-GlnIleArgAspGlyGlyAspAlaLeuHisTyrLeuAsnArgIle-52 86-HisGlyGluHisHis-90 109-GlyTyrLeuTyrAsnGlyValHisGlu-117 138-ArgGlnValAspGlyLeuMetSerAlaIleTyr-148 182-ArgPheGluArgHisCys-187 194-ProGluAlaGlyArgLysTyrTyrArgAsnAla-204 281-ArgProValArgValLeuThrAlaGly-289 315-TyrThrAlaVa1PheAspTyrVa1ArgAsnGlyArgArgAla-328 Antigenic Index - Jameson-Wolf 21-ThrGlnAsnGlnSerLeuProAlaGly-29 32-ValTyrProSerAlaProGlnIleArgAspGlyGlyAspAla-45 69-AsnSerAlaArgArgHisAlaArg-76 80-LeuAsnProGluAspGlyHisGlyGluHisHisProAspAsnProHis-95 99-GlnLysLeuThrGluArgThrArgLeu-107 115-ValHisGluAsnIleSerThrGluGluGluAlaAlaGluSerSerAspSerAspIleArgThrGlnGlnArg GlnValAspGlyLeu-143 152-SerLeuLeuAspArgHisThrAspGluAlaGly-162 165-PheValArgGluAsnGlyLysThr-172 178-GlnGlyAsnGlyArgPheGluArgHisCysAlaGlnGlyArgAsnGlnProGluAlaGlyArgLysTyrTyr ArgAsnAlaCysHisAsnGly-208 212-TyrThrAspGluAlaMetPro-218 237-PheHisGlyGluArgProAspProValProGluTyrGluIleThrGlyAsnProAlaSer-256 258-AspPheSerGluAlaAlaGly-264 266-IleThrMetLysSer-270 274-TyrGlnGlyLysAsnGluIleArgPro-282 287-ThrAlaGlyAsnAspProAsnGlyArgLeuThr-297 320-AspTyrValArgAsnGlyArgArgAlaGlnAla-330 334-PheArgThrArgLysProAspTyrProTyr-343 345-GluValAsnGlyGlyGluThrLeuAlaValArgLysGlyGluLys-359 364-TrpArgGlyArgTrpCysLeu-370 376-TyrThrTyrArgGlnArgProGlySerArgLeuSerIleGlyArgHisLysAlaGlyGly-395 401-AspGlyMetAlaGlySer-406 408-IleThrLeuAlaProGluGlyGluThrGluArgGly-419 Hydrophilic Regions - Hopp-Woods 37-ProGlnIleArgAspGlyGlyAsp-44 69-AsnSerAlaArgArgHisAlaArg-76 81-AsnProGluAspGlyHisGlyGluHisHisProAsp-92 100-LysLeuThrGluArgThrArgLeu-107 119-IleSerThrGluGluGluAlaAlaGluSerSerAspSerAspIleArgThrGlnGlnArgGlnValAsp-14 1 152-SerLeuLeuAspArgHisThrAspGluAlaGly-162 165-PheValArgGluAsnGlyLys-171 179-GlyAsnGlyArgPheGluArgHisCysAlaGlnGlyArgAsnGlnProGluAlaGlyArgLysTyrTyrArg -202 238-HisGlyGluArgProAspProValProGlu-247 258-AspPheSerGluAlaAlaGly-264 266-IleThrMetLysSer-270 275-GlnGlyLysAsnGluIleArgPro-282 289-GlyAsnAspProAsnGlyArg-295 323-ArgAsnGlyArgArgAlaGlnAla-330 334-PheArgThrArgLysProAsp-340 352-LeuAlaValArgLysGlyGluLys-359 377-ThrTyrArgGlnArgProGlySer-384 387-SerIleGlyArgHisLysAla-393 412-ProGluGlyGluThrGluArgGly-419 a538 AMPHI Regions - AMPHI 42-ThrAlaLeuAlaGluAlaValGluLeuValLysAlaAlaGly-55 79-LysAlaAlaGluLeuSerGluAlaValAla-88 105-GlnGluArgAsnLeuGluLysI1eLeuGlnCysArgValLeuAspArgVal-121 145-GlnLeuSerHisLeuAlaGlyArgLeuIleArgGlyTyrGlyHisLeuGln-161 188-IleAsnAlaLeuLysLysGlnLeuAla-196 211-SerGlyThrIleLysThrPheAlaLeuValGlyTyrThrAsn-224 231-PheAsnArgLeuThrLys-236 271-GlyPheValSerAspLeuProHisLysLeuIleSerAlaPheSerAlaThrLeuGlu-289 307-AsnSerGlyGlnGlnIleGluAspValGluAsnValLeuGlnGluIleHis-323 365-GluAsnThrGlyIleAspAlaLeuArgGluAlaIleAlaGluTyrCysAla-381 Antigenic Index - Jameson-Wolf l-MetThrGlyArgThrGlyArgAsnGlySerThrGlnAlaGlnProGluArgVal-18 24-MetLeuAspLysAspGlyThrGlySerSerAlaThrArgLeuAsnGly-39 48-ValGluLeuValLys-52 54-AlaGlyGlyAspSerValArgValGluThrAlaLysArgAspArgProHisThr-71 77-ThrGlyLysAlaAlaGluLeuSerGlu-85 100-GluLeuThrProThrGlnGluArgAsnLeuGluLys-111 129-AlaArgArgAlaArgThrGlnGluGlyArgLeuGlnVal-141 161-GlnSerGlnArgGlyGlyIleGlyMetLysGlyProGlyGluThrLysLeuGluThrAspArgArgLeuIle -184 189-AsnAlaLeuLysLysGlnLeuAlaAsnLeuLysLysGlnArgAlaLeuArgArgLysSerArgGluSerGly ThrIleLysThr-216 224-AsnValGlyLysSerSerLeu-230 233-ArgLeuThrLysSerGlyIleTyrAla-241 257-TyrIleSerProGluCys-262 287-ThrLeuGluGluThrAlaGln-293 304-AlaAlaProAsnSerGlyGlnGlnIleGluAspValGluAsnValLeu-319 323-HisAlaGlyAspIlePro-328 333-TyrAsnLysThrAspLeuLeuProSerGluGluGlnAsnThrGlyIle-348 365-GluAsnThrGlyIleAspAlaLeuArgGluAlaIle-376 381-AlaAlaAlaProAsnThrAspGluThrGluMetPro-392 Hydrophilic Regions - Hopp-Woods 1-MetThrGlyArgThrGlyArgAsnGlySerThr-ll 13-AlaGlnProGluArg-17 25-LeuAspLysAspGlyThrGly-31 48-ValGluLeuValLys-52 54-AlaGlyGlyAspSerValArgValGluThrAlaLysArgAspArgProHis-70 78-GlyLysAlaAlaGluLeuSerGlu-85 101-LeuThrProThrGlnGluArgAsnLeuGluLys-111 129-AlaArgArgAlaArgThrGlnGluGlyArgLeuGlnVal-141 161-GlnSerGlnArgGlyGlyIle-167 171-GlyProGlyGluThrLysLeuGluThrAspArgArgLeuIle-184 189-AsnAlaLeuLysLysGlnLeuAlaAsnLeuLysLysGlnArgAlaLeuArgArgLysSerArgGluSerGly Thr-213 287-ThrLeuGluGluThrAlaGln-293 310-GlnGlnIleGluAspValGluAsnValLeu-319 337-AspLeuLeuProSerGluGluGlnAsn-345 370-AspAlaLeuArgGluAlaIle-376 384-ProAsnThrAspGluThrGluMetPro-392 a539-2 AMPHI Regions - AMPHI 18-ArgGlnArgGluHisHisArgLeu-25 44-LeuValGlyGlyPheAspPheLeuArgValIleGlyCysGlyGlyValAlaTyrLeuProAspPheGlnGln- 67 Antigenic Index - Jameson-Wolf l-MetGluAspLeuGlnGluIleGly-8 15-LysValGlyArgGlnArgGluHisHisArgLeuHisHisProGlnProGlyAsnGlyGluAlaAspAsp-37 63-ProAspPheGlnGlnAsnValGlyLysAlaAsp-73 77-ValProAspAspAlaAlaAla-83 88-IleGluValAspAlaAspAspAlaValCys-97 102-LeuPheAspGlnProAspAlaGlyGlyAlaGlyAspAlaAlaGluHis-117 Hydrophilic Regions - Hopp-Woods l-MetGluAspLeuGlnGluIleGly-8 15-LysValGlyArgGlnArgGluHisHisArg-24 31-GlyAsnGlyGluAlaAspAsp-37 69-ValGlyLysAlaAsp-73 78-ProAspAspAlaAlaAla-83 88-IleGluValAspAlaAspAspAlaValCys-97 102-LeuPheAspGlnProAspAlaGlyGlyAlaGlyAspAlaAlaGluHis-117 a542 AMPHI Regions - AMPHI 6-Argl1eArgArgCysSerVal-12 Antigenic Index - Jameson-Wolf l-MetProLysTrpSerArgIleArgArgCysSerVal-12 20-SerAlaSerArgLeuThrCys-26 36-MetArgLeuLysSerSerAspGlyIleAlaSer-46 55-GlyProMetProSerGluThrValSerHisLysSerAspSerSerArgAsnThrSerAlaSerArgArgAsnV alSerProLysCysProPhe-85 89-PheArgGlnAspAlaAlaLysProArgArgPheGlyGlyLys-102 106-LeuThrGlySerArg-110 Hydrophilic Regions - Hopp-Woods 5-SerArgIleArgArgCysSer-ll 36-MetArgLeuLysSerSerAspGlyIleAla-45 57-MetProSerGluThrValSerHisLysSerAspSerΞerArgAsnThrSerAlaSerArgArgAsnValSerP ro-81 89-PheArgGlnAspAlaAlaLysProArgArgPheGlyGly-101 a544-2 AMPHI Regions - AMPHI ll-AlaLeuIleGlyIleLeu-16 55-PheTrpPheProSerCysProGlyCysValSerGluMetProLysIleIleLysThrAla-74 85-LeuAlaValAlaGlnProIleAspProIleGluSerValArgGlnTyrVal-101 116-LysAlaValGlyGlnAlaPhe-122 Antigenic Index - Jameson-Wolf 1-MetLysLysI1eLeu-5 22-IleProAspSerLysThrAlaPro-29 35-AspLeuHisGlyLysThrValSerAsnAlaAspLeuGlnGly-48 59-SerCysProGlyCys-63 66-GluMetProLysIleIleLysThrAlaAsnAspTyrLysAsnLysAsnPhe-82 90-ProIleAspProIleGluSerValArgGlnTyrValLysAspTyrGly-105 113-AspAlaAspLysAlaVal-118 133-IleGlyLysLysGlyGluIleLeu-140 144-ValGlyGluProAspPheGlyLysLeuTyrGlnGluIleAspThr-158 Hydrophilic Regions - Hopp-Woods 1-MetLysLysI1eLeu-5 23-ProAspSerLysThr-27 66-GluMetProLysIleIleLysThrAlaAsnAspTyrLysAsnLysAsn-81 92-AspProIleGluSerValArgGlnTyrValLys-102 113-AspAlaAspLysAlaVal-118 133-IleGlyLysLysGlyGluIle-139 a547 AMPHI Regions - AMPHI 7-PheAsnLysThrValAlaSerPheAlaGlnIleValGluThrPheAspVal-23 62-AsnArgSerPheLys-66 105-LeuHisIlePheThrAsnIleLys-112 Antigenic Index - Jameson-Wolf 3-ValAspAsnGlyPheAsnLysThrVal-ll 35-GlnMetLysGlnArgCysGlyTrp-42 53-PheProArgCysGlyPheGluIleProAsnArgSerPheLysGlu-67 76-LeuSerGluArgPheArgThrAsnAlaGluValGluIle-88 Hydrophilic Regions - Hopp-Woods 36-MetLysGlnArgCys-40 60-IleProAsnArgSerPheLysGlu-67 76-LeuSerGluArgPheArgThrAsnAlaGluValGluIle-88 a548 AMPHI Regions - AMPHI 14-ValLeuAlaAlaLeuAlaAlaCysLys-22 39-SerAlaAlaGluAsnAlaAlaLysPro-47 89-PheThrHisCysProAspValCysProThr-98 103-TyrSerAspThrLeuLysGlnLeuGlyGlyGln-113 132-GluIleIleGlyLysTyrAlaLys-139 Antigenic Index - Jameson-Wolf 21-CysLysProGlnAspAsnSerAlaAla-29 39-SerAlaAlaGluAsnAlaAlaLysProGlnThrArgGlyThrAspMetArgLysGluAspIleGlyGlyAspP heThrLeuThrAspGlyGluGlyLysProPheAsn-74 76-SerAspLeuLysGly-80 91-HisCysProAspValCysPro-97 104-SerAspThrLeuLysGlnLeuGlyGlyGlnAlaLysAspValLys-118 124-IleAspProGluArgAspThrProGluIleIleGlyLysTyrAlaLysGlnPheAsnProAspPhe-145 150-AlaThrGlyAspGlnAsnLeu-156 169-LysValAsnGlnLysAspAspSerGluAsnTyrLeu-180 189-LeuIleAspLysAsnGlyGlu-195 200-SerProTyrGlySerGluProGluThrIleAlaAlaAspVal-213 Hydrophilic Regions - Hopp-Woods 22-LysProGlnAspAsnSerAla-28 39-SerAlaAlaGluAsnAlaAlaLysProGlnThrArgGlyThrAspMetArgLysGluAspIleGlyGly-61 64-ThrLeuThrAspGlyGluGlyLysPro-72 76-SerAspLeuLysGly-80 lll-GlyGlyGlnAlaLysAspValLys-118 124-IleAspProGluArgAspThrProGluIleIle-134 151-ThrGlyAspGlnAsn-155 169-LysValAsnGlnLySAspAspSerGluAsnTyrLeu-180 191-AspLysAsnGlyGlu-195 203-GlySerGluProGluThrIleAlaAlaAspVal-213 a552-l AMPHI Regions - AMPHI 18-CysThrAsnAlaPheAlaAlaPro-25 29-AlaSerLeuAlaArgTrpLeuAspThr-37 41-AspArgAspIleGluLysAsnMetIleGluGlyPheAsnAlaGlyPheLysProTyrAlaAspLysAlaLeuA laGluMet-67 75-AlaAlaGluAlaPheAsnArgTyrArgGluAsnVal-86 89-AspLeuIleThrProGluValLys-96 116-IleAspGlyMetIleAla-121 139-IleLysLysSerMetSerGluIle-146 154-SerGlyLysIleAlaGlnHisHisLeuProGluPheThrGluGluLeuArgArg-171 Antigenic Index - Jameson-Wolf 25-ProProSerAspAlaSerLeu-31 35-LeuAspThrGlnAsnPheAspArgAspIleGluLysAsnMe Ile-49 53-AsnAlaGlyPheLysProTyrAlaAspLysAlaLeuAlaGluMetProGluAlaLysLysAspGlnAlaAla- 76 78-AlaPheAsnArgTyrArgGluAsnValLeu-87 90-LeuIleThrProGluValLysGlnAlaVal-99 105-LysAsnAlaArgGluIleTyrThrGlnGluGluIleAspGly-118 131-ValValAlaLysAsnProArgLeuIleLysLysSerMetSer-144 153-LeuSerGlyLysIle-157 164-GluPheThrGluGluLeuArgArg-171 173-IleCysGlyGlyLysAsnProAspAlaGlyCysLysGlnAlaGlyGlnValGlyLysArgHisGlnLys-19 5 Hydrophilic Regions - Hopp-Woods 26-ProSerAspAlaSerLeu-31 38-GlnAsnPheAspArgAspIleGluLysAsnMetIle-49 58-ProTyrAlaAspLysAlaLeuAlaGluMetProGluAlaLysLysAspGlnAlaAla-76 78-AlaPheAsnArgTyrArgGluAsnValLeu-87 90-LeuIleThrProGluValLysGlnAlaVal-99 105-LysAsnAlaArgGluIleTyrThr-112 114-GluGluIleAspGly-118 131-ValValAlaLysAsnProArgLeuIleLysLysSerMetSer-144 164-GluPheThrGluGluLeuArgArg-171 176-GlyLysAsnProAspAlaGlyCysLysGlnAlaGlyGlnValGlyLysArgHisGlnLys-195 a554 AMPHI Regions - AMPHI 38-PheGlnThrProGluThrLeu-44 71-AlaAlaLeuThrGlnLeuMet-77 110-ArgMetPheValArgProGlyAspThrVal-119 124-LeuLeuLysGlyMet-128 148-SerIleGluAsnPheValGlnGlnMetAsnLysGlu-159 185-AlaLysAspLeuAlaGlnLeuSerGluAlaLeuMetArgAspPheProGluTyrTyrProLeuPheSer-20 7 296-ThrValAlaGlnIle-300 331-GluGlnIleLeuGluThrIleGlnProIleProAla-342 Antigenic Index - Jameson-Wolf 23-AlaSerProAlaProAsnArgProThrAla-32 37-ThrPheGlnThrProGluThr-43 53-LeuGlnSerLysGln-57 61-AlaLysAsnIleAsnThrProValGlu-69 84-LysAsnMetLysSerGlyAsnIleArgSerGluGluAsnLeuLysIleProGlu-lOl 104-TrpAlaSerGluGlySerArgMetPheValArgProGlyAspThrValSerThrAspLysLeuLeu-125 143-ArgLeuGlyAsnGlySerIleGluAsnPhe-152 156-MetAsnLysGluAlaArgArgLeuGlyMetLysAsnThrValPheLysAsnProThrGlyLeuSerArgGlu GlyGlnValSerThrAlaLysAspLeuAlaGln-190 194-AlaLeuMetArgAspPheProGluTyrTyr-203 214-LysAsnIleGluGlnAsnAsnArgAsnIleLeu-224 226-TyrArgAspAsnAsnValAsnGlyLeuLysAlaGlyHisThrGluSerGlyGlyTyrAsn-245 250-TyrSerGlyAsnGlyArgHis-256 262-LeuGlySerGluSerAlaGluThrArgAlaSerAspAsnSerLys-276 285-PheAspThrProLysIleTyrProLysGlyLysThr-296 302-IleSerGlyGlySerLysLysThrValArg-311 323-ProHisLysGluAlaLysMetAlaGluGlnIleLeu-334 342-AlaProValLysLysGlyGlnIleLeuGlyLysIleLysIleArgGlnAsnGlyTyr-360 362-IleAlaGluLysGluIleValAla-369 371-GluAsnValLysLysArgSerArgTrpGlnArg-381 Hydrophilic Regions - Hopp-Woods 26-AlaProAsnArgProThrAla-32 85-AsnMetLysSerGlyAsnIleArgSerGluGluAsnLeuLysIleProGlu-101 107-GluGlySerArgMetPheValArgProGlyAspThrValSerThrAspLysLeuLeu-125 156-MetAsnLysGluAlaArgArgLeuGlyMet-165 174-ThrGlyLeuSerArgGluGlyGlnValSerThrAlaLysAspLeuAlaGln-190 214-LysAsnIleGluGlnAsnAsnArg-221 227-ArgAspAsnAsnValAsn-232 237-GlyHisThrGluSerGly-242 264-SerGluSerAlaGluThrArgAlaSerAspAsnSerLys-276 289-LysIleTyrProLysGlyLysThr-296 304-GlyGlySerLysLysThrValArg-311 323-ProHisLysGluAlaLysMetAlaGluGlnIleLeu-334 343-ProValLysLysGlyGlnIle-349 353-IleLysIleArgGln-357 362 -IleAlaGluLysGluIleValAla-369 371-GluAsnValLysLysArgSerArgTrp-379 a556 AMPHI Regions - AMPHI 61-IleGluArgLeuLys-65 Antigenic Index - Jameson-Wolf l-MetAspAsnLysThrLysLeuArgLeu-9 52-ThrSerArgArgGlnGlnArgGlnPheIleGluArgLeuLysLysPheAspIleAspProGluLysGlyArgI leAsnGluAlaAsnLeuArgArgMetTyrHisSerGlyGlyGlnHisGlnLysAspAla-95 102-SerGlnLysCysSerValAspGluAlaHisAlaMetPheLysLysArgProThrArgGlnGluIleAsn-12 4 127-AlaAlaLysGlnSerArgGlyGlnLysArgProHisArg-139 Hydrophilic Regions - Hopp-Woods l-MetAspAsnLysThrLysLeuArgLeu-9 53-SerArgArgGlnGlnArgGlnPheIleGluArgLeuLysLysPheAspIleAspProGluLysGlyArgIleA snGluAlaAsnLeuArgArgMetTyr-85 9O-GlnHisGlnLysAspAla-95 105-CysSerValAspGluAlaHisAlaMetPheLysLysArgProThrArgGlnGluIleAsn-124 127-AlaAlaLysGlnSerArgGlyGlnLysArgProHisArg-139 a557 AMPHI Regions - AMPHI 22-GlyAlaAspGlyIle-26 55-SerGlyArgValAspAspAlaAla-62 Antigenic Index - Jameson-Wolf 20-LeuLysGlyAlaAspGlyIleSerProProLeuThrTyrArgSerTrpHisIleGluGlyGlyGlnAlaLeu- 43 54-AlaSerGlyArgValAspAspAlaAlaGly-63 68-LeuArgIleAspSerValSerGlnAsnLysGluThrTyrThr-81 100-GlnValLeuLysArgGlyGluProValGlyLysProMet-112 123-AlaAspAsnGluIleLeuGlyLysGlnGluGluGluAla-135 141-MetArgGlnAspAlaAlaGluGlnIleValArg-151 Hydrophilic Regions - Hopp-Woods 21-LysGlyAlaAspGlyIle-26 56-GlyArgValAspAspAlaAlaGly-63 68-LeuArgIleAspSerValSerGlnAsnLysGluThrTyrThr-81 100-GlnValLeuLysArgGlyGluProValGly-109 126-GluIleLeuGlyLysGlnGluGluGluAla-135 141-MetArgGlnAspAlaAlaGluGlnIleValArg-151 a560 AMPHI Regions - AMPHI 30-PheArgAspGlyAlaHisLysMetAlaArgValTrpValLysIleLeu-45 167-ArgMetAlaLysMetPhe-172 192-PheLeuLysTyrProGlyGlu-198 218-MetGlyLysCysGluHisLeuIleGlu-226 Antigenic Index - Jameson-Wolf 29-ProPheArgAspGlyAlaHisLysMet-37 61-GlyAlaGluAsnIleProAspArgProAla-70 76-HisGlnSerGlyTrpGlu-81 95-ValAlaLysArgGluLeuPhe-101 116-IleGlyIleAspArgAsnAsnArgArgGluAlaAsnGluGlnLeuIle-131 134-GlyLeuAlaArgLysAsnGluGlyTyr-142 148-ProGluGlyThrArgLeuAlaProGlyLysArgGlyLysTyrLysLeuGlyGly-165 182-AsnSerGlyGluPheTrpProLysAsnSerPheLeuLysTyrProGlyGluIle-199 209-HisAlaSerGlySerGluAlaGluLeuMetGlyLysCysGluHisLeuIle-225 242-MetProSerGluThrAla-247 Hydrophilic Regions - Hopp-Woods 29-ProPheArgAspGlyAlaHisLysMet-37 64-AsnIleProAspArgProAla-70 95-ValAlaLysArgGluLeuPhe-101 116-IleGlyIleAspArgAsnAsnArgArgGluAlaAsnGluGlnLeuIle-131 134-GlyLeuAlaArgLysAsnGlu-140 149-GluGlyThrArgLeuAlaProGlyLysArgGlyLysTyrLysLeuGlyGly-165 211-SerGlySerGluAlaGluLeuMetGlyLysCysGluHisLeuIle-225 242-MetProSerGluThrAla-247 a561 AMPHI Regions - AMPHI 22-GlyLeuTrpValGlyLeuAlaAla-29 46-AlaSerValIleGluGluAlaGlyAsn-54 79-ValAlaGluPheGluLysSerLeuLysArgIleAlaGln-91 128-SerTyrArgArgProThrGlnVal-135 172-MetThrLeuValSerSer-177 188-ValIleArgProLeuGlnAlaLeuArgGluGlyAlaGluArgIleGlyArgArgCysPheAspIle-209 219-PheLysGlnValGlyArgCysPheAsnGlnMet-229 238-AspAspLeuGluGlyGlnValAlaGluGlnThrArgSerLeuGluLysGln-254 265-ThrArgAspLeuHisGlnSer-271 275-GlnGlnAlaAlaGluHisPhe-281 283-AsnArgIleLeuPro-287 317-AlaSerAspLeuGlyLysTyrHisGlu-325 339-ArgLeuLeuLeuSerPheProAsnGly-347 358-LeuGlnThrLeuGlyArgGlnLeuGly-366 392-GlnGlyLeuHisAspSerIleAlaGlnAlaLeuThr-403 434-GlyValGlnGluCysTyrGluAspValArgGluLeu-445 456-LysGluPheProGluAlaValAlaAspLeuPheSerArgPheThrGlnGlnThrGly-474 504-LeuSerAsnIleArgLysHisAla-511 540-ThrGluAsnIleGlyGluProSer-547 Antigenic Index - Jameson-Wolf 6-ArgPheSerAspGlyIleSer-12 48-ValIleGluGluAlaGlyAsn-54 66-AlaGlyGluGlySerProArgAlaGlnIleAspAsnGlnValAlaGluPheGluLysSerLeuLysArgIleA laGlnSerAspAlaIleHisPro-97 99-IleProSerAspThrProLeu-105 124-ProProLeuGlnSerTyrArgArgProThrGlnValAspLeu-137 152-GluAsnAlaAsnGluLysAsnThr-159 193-GlnAlaLeuArgGluGlyAlaGluArgIleGlyArgArgCysPheAsp-208 210-ProValProGluGlyGlyThrProGluPheLysGlnValGlyArgCysPheAsnGlnMetGlyGlyArgLeu LysIleLeuTyrAspAspLeuGluGlyGlnValAlaGluGlnThrArgSerLeuGluLysGlnAsnGlnAsnLeu- 258 263-GlnThrThrArgAspLeuHisGlnSerTyrIle-273 289-ValGlyAlaAspSerGlyArgValCysLeuAspGlyGlySerAsp-303 310-HisAlaAspCysGlyThrAlaAlaSerAspLeuGlyLysTyrHisGlu-325 332-TyrGlnAsnGluThrLeuGly-338 344-PheProAsnGlyIleSerLeuAspGluAspAspArgIleLeu-357 360-ThrLeuGlyArgGlnLeu-365 371-GlyAlaLysGlnGluGluGluLysArgLeu-380 384-LeuGlnGluArgAsnLeu-389 394-LeuHisAspSerIle-398 415-AlaPheAlaGluAsnLysArgGluGluAlaAlaGlu-426 434-GlyValGlnGluCysTyrGluAspValArgGlu-444 450-ArgThrLysIleSerAsnLysGluPheProGluAlaVal-462 468-ArgPheThrGInGInThrGlyThrThrVa1-477 480-AlaTrpGluAsnGlyThrHisLeuProThrGlnAspGluGlnLeu-494 503-SerLeuSerAsnIleArgLysHisAlaHis-512 519-ArgLeuLeuLysGlnAspGlySerPheThr-528 531-IleGlnAspAsnGlyGlnGlyPheAspThrGluAsnIleGlyGluProSerGlySerHis-550 556-MetGlnGluArgAlaLysArgIle-563 568-GluIleArgSerGlnAlaGlnGlnGlyThrThr-578 584-AlaSerGluGluSerLeuLys-590 Hydrophilic Regions - Hopp-Woods 48-ValIleGluGluAlaGlyAsn-54 68-GluGlySerProArgAlaGlnIle-75 78-GlnValAlaGluPheGluLysSerLeuLysArgIleAlaGln-91 128-SerTyrArgArgProThrGln-134 152-GluAsnAlaAsnGluLys-157 193-GlnAlaLeuArgGluGlyAlaGluArgIleGlyArgArgCysPhe-207 213-GluGlyGlyThrProGluPheLysGlnValGly-223 235-IleLeuTyrAspAspLeuGluGlyGlnValAlaGluGlnThrArgSerLeuGluLysGlnAsnGln-25( 264-ThrThrArgAspLeuHis-269 290-GlyAlaAspSerGlyArgValCysLeu-298 312-AspCysGlyThrAlaAlaSerAspLeuGlyLysTyrHisGlu-325 349-SerLeuAspGluAspAspArglleLeu-357 371-GlyAlaLysGlnGluGluGluLysArgLeu-380 384-LeuGlnGluArgAsnLeu-389 415-AlaPheAlaGluAsnLysArgGluGluAlaAlaGlu-426 437-GluCysTyrGluAspValArgGlu-444 451-ThrLysIleSerAsnLysGluPheProGluAlaVal-462 488-ProThrGlnAspGluGlnLeu-494 503-SerLeuSerAsnIleArgLysHisAlaHis-512 519- rgLeuLeuLysGlnAspGly-525 533-AspAsnGlyGlnGlyPheAspThrGluAsnIleGlyGluProSerGly-548 556-MetGlnGluArgAlaLysArgIle-563 568-GluIleArgSerGlnAlaGln-574 584-AlaSerGluGluSerLeuLys-590 a562 AMPHI Regions - AMPHI 48-TrpSerLeuValSerAlaTrpMetValValIle-58 84-LeuGluThrThrVal-88 90-SerAlaValArgMetLeu-95 97-PheThrProTyrThrThrValAlaSerThrSer-107 116-ThrPhePheAlaProLeuSerArgThrLeu-125 132-AsnAlaProValHisSerMetThrLysSerThrProSerSerPheHis-147 183-ValSerAsnLeuValArgTrpAlaLeu-191 Antigenic Index - Jameson-Wolf 10-AsnSerGlySerThrLysProThr-17 32-ProLeuArgAlaArgArgArgSerLeuTrpArg-42 72-AlaThrGlyGluArgGlnLeuVal-79 105-SerThrSerSerProProGlyAlaGluMet-114 138-MetThrLysSerThrProSerSerPheHisGlySerSerAla-151 154-ArgValXxxLysXxxGlyIle-160 167-ArgLeuProProSerTrpAspThrSerAlaSerLysArgProCysThr-182 Hydrophilic Regions - Hopp-Woods 33-LeuArgAlaArgArgArgSerLeuTrp-41 72-AlaThrGlyGluArgGlnLeuVal-79 110-ProGlyAlaGluMet-114 139-ThrLysSerThrPro-143 175-SerAlaSerLysArgProCysThr-182 a565 AMPHI Regions - AMPHI 50-AlaThrCysThrArgAlaMetSerLysSer-59 66-SerSerTrpAlaArg-70 84-IleSerThrTrpSerAspLeu-90 103-AspPheMetSerGlnLeuAspLeuThr-lll 140-SerHisSerSerGluThrIleSerSerCysProAlaMetAlaSerIleThrLysProAsn-159 184-AlaAsnThrThrSerAlaPhe-190 Antigenic Index - Jameson-Wolf 1-MetAspSerThrLeuSerLysThrCys-9 23-PheAlaArgProArgProAlaAlaSerAsnThrSerLeu-35 37-PheAlaSerProAsnAspThrGlySer-45 55-AlaMetSerLysSerSerAlaLysTyrGly~64 67-SerTrpAlaArgThrArgProThrValCysProProLeuProLysProThrIle-84 99-CysArgSerSerAspPheMetSer-106 109-AspLeuThrLysArgProThrSerAlaSerLeuProProLysArgLysGlyAlaIle-127 129-IleAspSerArgThrAlaAla-135 140-SerHisSerSerGluThrIleSerSerCysProAla-151 155-IleThrLysProAsnSerProProCysAlaArgTyr-166 170-LeuArgLeuSerProThrGlu-176 194-SerIleAlaAsnSerIleAsnThrCysArgGlnProPro-206 Hydrophilic Regions - Hopp-Woods 24-AlaArgProArgProAlaAla-30 39-SerProAsnAspThrGlySer-45 55-AlaMetSerLysSerSerAla-61 69-AlaArgThrArgPro-73 100-ArgSerSerAspPhe-104 109-AspLeuThrLysArgProThrSer-116 119-LeuProProLysArgLysGlyAlaIle-127 129-IleAspSerArgThr-133 141-HisSerSerGluThrIleSer-147 156-ThrLysProAsnSer-160 a566 Antigenic Index - Jameson-Wolf 35-TyrProAsnCysGlyAlaAspGlyAlaGlyGlyLysGlyHis-48 61-AlaValGlyGlyGluGluGlyGlyValValAlaAspAspValAlaArgAlaAspGlyGlyLysAlaAspGlyG lyArglleAlaArg-89 105-SerAlaGluArgAlaGlyAspAspPheAla-114 Hydrophilic Regions - Hopp-Woods 39-GlyAlaAspGlyAlaGlyGlyLysGlyHis-48 63-GlyGlyGluGluGlyGlyValValAlaAspAspValAlaArgAlaAspGlyGlyLysAlaAspGlyGlyArgI leAlaArg-89 105-SerAlaGluArgAlaGlyAspAspPheAla-114 a567 AMPHI Regions - AMPHI 60-GlyValTyrGlnVal-64 98-GluLeuValGlnGluIleAlaArgGluVal-107 112-AlaLeuLysAlaVal-116 154-TyrAlaLeuGluGlyIleSerAspLeuIleAlaThrValArgLysIleArgGln-171 180-ThrGlyIleValArg-184 195-AlaGluValSerGluGlnLeuArgSerHisPheGlyAspLeuLeu-209 Antigenic Index - Jameson-Wolf 10-AsnGlnLysGlyGlyValGlyLysThrThrThr-20 28-LeuAlaSerArgGlyLysArg-34 38-ValAspLeuAspProGlnGlyAsnAlaThrThrGlySerGlyIleAspLysAlaSerLeuGlnSerGly-60 67-GlyAspAlaAspValLysSerAlaAlaValArgSerLysGluGlyGlyTyr-83 95-AlaGluIleGluLeu-99 101-GlnGluIleAlaArgGluValArgLeuLysAsnAlaLeu-113 115-AlaValAlaGluAspTyrAsp-121 127-CysProProSerLeu-131 164-AlaThrValArgLysIleArgGlnAlaValAsnProAspLeuAspIle-179 185-ThrMetTyrAspSerArgSerArgLeuValAlaGluValSerGluGlnLeuArgSerHisPheGlyAspLeu -208 214-IleProArgAsnIleArgLeuAlaGluAlaProSerHisGly-227 235-AlaGlnAlaLysGlyAlaLys-241 248-AspGluLeuMetAla-252 Hydrophilic Regions - Hopp-Woods 10-AsnGlnLysGlyGlyValGlyLys-17 28-LeuAlaSerArgGlyLysArg-34 40-LeuAspProGlnGly-44 50-SerGlyIleAspLysAlaSerLeu-57 67-GlyAspAlaAspValLysSerAlaAlaValArgSerLysGluGlyGly-82 95-AlaGluIleGluLeu-99 101-GlnGluIleAlaArgGluValArgLeuLysAsnAlaLeu-113 115-AlaValAlaGluAspTyrAsp-121 164-AlaThrValArgLysIleArgGln-171 175-ProAspLeuAspIle-179 186-MetTyrAspSerArgSerArgLeuValAlaGluValSerGluGlnLeuArg-202 216-ArgAsnIleArgLeuAlaGluAlaProSer-225 235-AlaGlnAlaLysGlyAlaLys-241 248-AspGluLeuMetAla-252 a568 AMPHI Regions - AMPHI 31-SerIlePheArgArg-35 48-LysAlaCysLysAsn-52 70-GluLysAlaAsnThrValArgTyr-77 81-SerLeuAlaGlnCysPheThr-87 lll-ArgProLeuProSerIleIleThrAla-119 168-GluPheValGlyPheGlyAsnValPheValGlyGlnPheLeuAsnArgPhePhe-185 199-GluGluPhePheAspValValVal-206 227-PheAsnGlnValPheAlaAlaPheLeu-235 240-HisArgHisAlaAspGlnValAlaAspSerCysArgValGlnSerGln-255 Antigenic Index - Jameson-Wolf 22-IleArgLeuLysArgSerArgLeuProSerIlePhe-33 38-PheSerCysArgArgArgThrCysPheCysLysAlaCysLysAsnSerProIleArgAsnGluThrSerSerS erGlyArgArgGlnPheSerValGluLysAlaAsnThr-74 90-SerAsnAlaSerLysProArgLeu-97 99-ProIleMetArgGlyArgLysArgPhePheAla-109 140-PheArgGlySerAlaPheLysCysArgLeuAsnAlaGluProCysArg-155 213-AlaAspGlyAspAla-217 236-GlyGlnHisGlyHisArgHisAlaAspGlnValAlaAspSerCysArgValGlnSerGln-255 Hydrophilic Regions - Hopp-Woods 22-IleArgLeuLysArgSerArgLeu-29 40-CysArgArgArgThrCysPhe-46 48-LysAlaCysLysAsnSerProIleArgAsnGluThrSe SerSerGlyArgArgGlnPheSerValGluLysA laAsnThr-74 92-AlaSerLysProArgLeu-97 101-MetArgGlyArgLysArgPhePheAla-109 143-SerAlaPheLysCysArgLeuAsnAlaGluProCysArg-155 238-HisGlyHisArgHisAlaAspGlnValAlaAspSerCysArgVal-252 a569-2 AMPHI Regions - AMPHI 29-AlaAlaPheCysGlyLeuIleAlaLeuThrAlaLeuTrpGluTyrAlaArgMetAlaGlyLeuCysLys-51 86-PheTrpLeuAlaValMetPro-92 161-IleAlaArgAlaIleSerProGlyLysSerTrpGluGlyAlaIle-175 203-ThrValLeuIleGlyLeu-208 210-LeuThrValValSerValCysGlyAspLeuLeuGluSerTrpLeuLys-225 Antigenic Index - Jameson-Wolf 50-CysLysThrGluThrAsnHis-56 98-LysTrpArgLeuAsnGlyGlyTrp-105 124-SerLeuArgProHisProAspAspAlaLeu-133 154-LysAlaLeuGlyLysHisLysIleAlaArg-163 165-IleSerProGlyLysSerTrpGlu-172 227-AlaAlaGlyIleLysAspSerSerAsnLeuLeuProGlyHis-240 242-GlyValPheAspArgThrAspSer-249 Hydrophilic Regions - Hopp-Woods 50-CysLysThrGluThr-54 127-ProHisProAspAspAlaLeu-133 155-AlaLeuGlyLysHisLysIleAlaArg-163 227-AlaAlaGlyIleLysAspSerSerAsn-235 243-ValPheAspArgThrAspSer-249 a570 AMPHI Regions - AMPHI 6-ArgAlaPheAlaAlaAlaLeuIleGlyLeu-15 22-HisAlaAspThrPheGlnLysIleGlyPheIleAsn-33 43-GlnAlaArgLysIleGlnLysThrLeuAspSer-53 60-AspGluLeuGlnLysLeuGln-66 81-LeuLysAspAlaLysLys-86 122-LeuGlnGlnAsnAlaAsnArgValIleValLysIle-133 Antigenic Index - Jameson-Wolf 33-AsnThrGluArgIleTyrLeuGluSerLysGlnAlaArgLysIleGlnLysThrLeuAspSerGluPheSerA laArgGlnAspGluLeuGlnLysLeuGlnArgGluGlyLeuAspLeuGluArgGlnLeuAlaGluGlyLysLeuLy sAspAlaLysLysAlaGlnAlaGluGluLysTrp-93 100-PheArgLysLysGlnAlaGlnPheGluGluAspTyrAsnLeuArgArgAsnGluGluPheAla-120 123-GlnGlnAsnAlaAsnArgVal-129 133-IleAlaLysGlnGluGlyTyrAspValIle-142 150-AsnThrGlnTyrAspValThrAspSerValI1eLysGluMetAsnAlaArg-166 Hydrophilic Regions - Hopp-Woods 37-IleTyrLeuGluSerLysGlnAlaArgLysIleGlnLysThrLeuAspSerGluPheSerAlaArgGlnAspG luLeuGlnLysLeuGlnArgGluGlyLeuAspLeuGluArgGlnLeuAlaGluGlyLysLeuLysAspAlaLysLy sAlaGlnAlaGluGluLysTrp-93 lOO-PheArgLysLysGlnAlaGlnPheGluGluAspTyrAsnLeuArgArgAsnGluGluPheAla-120 133-IleAlaLysGlnGluGlyTyr-139 154-AspValThrAspSerValIleLysGluMetAsnAlaArg-166 a571 AMPHI Regions - AMPHI 6-AlaValAsnValLeu-10 40-AspGlyAlaArgValPheArgAl Gly-48 63-AlaAlaValAlaAspPhePheAlaVal-71 94-ValGluValPheLysGlu-99 Antigenic Index - Jameson-Wolf 13-AlaAlaGlyArgGlyThr-18 35-LysGlnAlaGlnAlaAspGlyAlaArgValPheArgAlaGlyHisArgGluGluGlnLeuGlyGlyAspVal- 58 77-ArgThrGluArgAlaAla-82 96-ValPheLysGluGlyAspPhe-102 110-ArgAsnAlaAspPheAlaAlaGluHisGlnArgGluGlyPheAlaGlyGluGluProGlyLeuValValGly -133 143-GlyGlnGlyAspPheGlyVal-149 154-ValAlaAlaArgArgPro-159 Hydrophilic Regions - Hopp-Woods 13-AlaAlaGlyArgGly-17 35-LysGlnAlaGlnAlaAspGlyAlaArgValPheArgAlaGlyHisArgGluGluGlnLeuGly-55 77-ArgThrGluArgAlaAla-82 96-ValPheLysGluGlyAspPhe-102 110-ArgAsnAlaAspPheAlaAlaGluHisGlnArgGluGlyPheAlaGlyGluGluProGly-129 154-ValAlaAlaArgArgPro-159 a572 AMPHI Regions - AMPHI 6-GlyAlaValGlyLeuProSerAlaLeuAla-15 61-GlnValLeuProArgAspTyrThrGlyArg-70 94-AsnThrPheAspSerIle-99 126-LysGlyLeuGluLeu-130 154-IleHisSerMetValArg-159 183-GlyLeuProGluArgIleAspSerGly-191 200-LeuSerAlaLeuThr-204 241-ValAlaAlaPheLeu-245 251-PheThrAspIleAlaLysThrValAlaHisCysLeuSerGlnAspPheSerAspGlyIleGlyAspIleGly Gly-275 Antigenic Index - Jameson-Wolf 18-GlnLysGlyLysThr-22 26-AlaAsnLysGluThrLeu-31 41-ThrAlaArgAlaAsnGly-46 51-ProValAspSerGluHis-56 63-LeuProArgAspTyrThrGlyArgLeuAsnGluHisGly-75 94-AsnThrPheAspSerIleThrProAspGlnAlaValLysHisProAsnTrpArgMetGlyArgLysIleSerV alAspSer-120 125-AsnLysGlyLeuGluLeu-130 138-AsnCysProProAspLysLeuGluVal-146 158-Va1ArgTyrArgAspGlySerVa1-165 170-GlyAsnProAspMetArgThr-176 184-LeuProGluArgIleAspSerGlyValGlyAspLeuAspPhe-197 204-ThrPheGlnLysProAspPheAspArg-212 263-SerGlnAspPheSerAspGlyIleGlyAspIleGly-274 279-GlnAspAlaArgThrArgAlaGlnAla-287 Hydrophilic Regions - Hopp-Woods 27-AsnLysGluThrLeu-31 41-ThrAlaArgAlaAsnGly-46 52-ValAspSerGluHis-56 66-AspTyrThrGlyArgLeuAsnGlu-73 lll-ArgMetGlyArgLysIleSerVal-118 126-LysGlyLeuGluLeu-130 140-ProProAspLysLeuGlu-145 158-ValArgTyrArgAspGlySer-164 170-GlyAsnProAspMetArgThr-176 184-LeuProGluArgIleAspSerGlyValGlyAspLeuAspPhe-197 206-GlnLysProAspPheAspArg-212 265-AspPheSerAspGlyIleGly-271 279-GlnAspAlaArgThrArgAlaGlnAla-287 a574 AMPHI Regions - AMPHI 6-ProAsnSerLeuGluLys-ll 47-LeuLysGlnAlaLysSerIleProSerGlyPheTyrLysSerLeuAspAlaLeuValAspArgAsnSerGlyA rgAlaAlaArgGluLeuAlaGluValValAsp-81 94-GlyLysLeuTyrArgGln-99 110-HisGlnThrLeuLeuAspSerProAspThrThrGly-121 175-GluLysAlaValGluThrAlaArgLeu-183 218-AsnValGlyLysAlaLeuGluAlaAsnLysLysCys-229 246-PheProAlaAlaValGluAlaTyrAlaAlaIleGlu-257 266-MetValGlyGluLysLeuTyrGluAlaTyrAla-276 281-ProGluGluGlyLeuAsnArgLeuThrGlyTyrMetGlnThrPheProGluLeuAspLeu-300 332-AsnGlyValTyrArg-336 357-ArgSerValIleGlyArgGlnLeuGlnArgSer-367 Antigenic Index - Jameson-Wolf 1-MetArgProAsnLeuProAsnSerLeuGluLysAlaAspMetAspAsn-16 45-ThrValLeuLysGlnAlaLysSerIleProSerGlyPheTyrLysSerLeuAspAlaLeuValAspArgAsnS erGlyArgAlaAlaArgGluLeuAlaGluValValAspGlyArgProGlnSerTyrAsp-88 96-LeuTyrArgGlnArgGlyGluAsnAspLysAlaIle-107 113-LeuLeuAspSerProAspThrThrGlyAlaLysArgAlaArgVal-127 135-TyrGlnSerAlaGlyLeuValAspArgAlaGlu-145 151-LeuGlnAspGlyGluMetAlaArgGluAlaArgGln-162 168-TyrGlnGlnAspArgAspTrpGluLysAlaValGluThr-180 182-ArgLeuLeuSerHisAspAspGlnThrTyr-191 210-SerAsnPheAspAlaAlaArg-216 221-LysAlaLeuGluAlaAsnLysLysCysThrArg-231 238-AspIleGluHisArgGlnGlyAsn-245 277-AlaGlnGlyLysProGluGluGlyLeuAsnArgLeuThrGlyTyr-291 312-LysCysGluLysGluAlaAla-318 323-GluLeuValArgArgLysProAspLeuAsnGly-333 341-LysLeuSerAspLeuAspProAlaTrpLysAlaAspAlaAspMetMetArg-357 368-ValMetTyrArgCysArgAsnCysHisPheLys-378 386-CysProAlaCysAsnLysTrpGlnThrPheThrProAsnLysIleGluVal-402 Hydrophilic Regions - Hopp-Woods l-MetArgProAsnLeu-5 7-AsnSerLeuGluLysAlaAspMetAspAsn-16 45-ThrValLeuLysGlnAlaLysSerIle-53 62-AspAlaLeuValAspArgAsnSerGlyArgAlaAlaArgGluLeuAlaGluValValAspGlyArgProGlnS er-86 96-LeuTyrArgGlnArgGlyGluAsnAspLysAlaIle-107 115-AspSerProAspThrThrGlyAlaLysArgAlaArgVal-127 140-LeuValAspArgAlaGlu-145 152-GlnAspGlyGluMetAlaArgGluAlaArgGln-162 169-GlnGlnAspArgAspTrpGluLysAlaValGluThr-180 184-LeuSerHisAspAspGlnThrTyr-191 211-AsnPheAspAlaAlaArg-216 221-LysAlaLeuGluAlaAsnLysLysCysThrArg-231 238-AspIleGluHisArgGlnGlyAsn-245 279-GlyLysProGluGluGlyLeuAsn-286 312-LysCysGluLysGluAlaAla-318 323-GluLeuValArgArgLysProAspLeu-331 341-LysLeuSerAspLeuAspPro-347 349-TrpLysAlaAspAlaAspMetMetArg-357 368-ValMe TyrArgCysArgAsnCysHis-376 398-AsnLysIleGluVal-402 a575 AMPHI Regions - AMPHI 8-PheArgLysProAlaSer-13 20-PheAlaGluAlaVal-24 42-SerThrValSerGlyLeuPheSerAla-50 114-LeuSerLysSerLysSer-119 139-SerSerAspSerPro-143 150-PheThrSerPhePheGly-155 163-ValSerThrSerAlaLysValIleSerMetPro-173 217-SerLysValTyrGluProProAsn-224 233-AlaGluThrCysSerThr-238 283-AlaGlyPheSerAlaPheAlaSerGlyAla-292 294-ThrPheAlaSerGlyPheSerThrGly-302 304-SerThrValAlaCys-308 311-GlySerAspGlyMetAspAlaValSerAlaLeu-321 Antigenic Index - Jameson-Wolf 2-ValSerGlyGluGluAlaPheArgLysProAlaSerProGluGlyGluAlaGlyPhe-20 34-GlyArgLeuSerGluLysSerValSer-42 54-ThrAspSerGlySerGlyVal-60 96-SerSerSerCysValSerAlaProAspLysMetProPhe-108 113-ArgLeuSerLysSerLysSerMetArgLeuGluGly-124 134-PheAlaAspAsnSerSerSerAspSerProSerLysAlaSerVal-148 155-GlyAlaGlySerGly-159 173-ProSerSerAlaAlaSerSerArgSerGlySerSerSerGlyThrAspSerSerValArgArgAlaArgLeu AspTrpAlaArgArgLysSerSerSerArgAlaIle-208 211-AlaProProProAlaSer-216 218-LysValTyrGluProProAsnSerProLeu-227 230-SerSerSerAlaGluThrCysSerThrGlySerGluThr-242 261-GlyAlaAspSerAlaAlaVal-267 276-GlyThrGlySerGlyArgThrAla-283 299-PheSerThrGlyPhe-303 309-LeuAspGlySerAspGlyMetAsp-316 Hydrophilic Regions - Hopp-Woods 2-ValSerGlyGluGluAlaPheArgLysProAlaSerProGluGlyGluAlaGlyPhe-20 34-GlyArgLeuSerGluLysSerValSer-42 101-SerAlaProAspLysMetPro-107 113-ArgLeuSerLysSerLysSerMetArgLeuGluGly-124 137-AsnSerSerSerAspSerProSerLysAla-146 176-AlaAlaSerSerArgSerGlySerSerSerGlyThrAspSerSerValArgArgAlaArgLeuAspTrpAla ArgArgLysSerSerSerArgAlaIle-208 231-SerSerAlaGluThrCysSerThrGlySerGluThr-242 310-AspGlySerAspGlyMetAsp-316 a576-l AMPHI Regions - AMPHI 31-AlaSerGluProAlaAlaAla-37 46-SerIleGlySerThr-50 63-GlyArgSerLeuLysGlnMetLys-70 82-ThrGluAlaMetGln-86 102-GlnGluValMetMetLysPheLeuGlnGluGlnGlnAlaLysAlaValGluLysHis-120 140-AlaLysAspGlyValLysThrThr-147 202-IleLeuGlyTrpThrGluGlyVal-209 Antigenic Index - Jameson-Wolf 20-AlaCysGlyLysLysGluAlaAlaPro-28 30-SerAlaSerGluProAlaAla-36 38-SerSerAlaGlnGlyAspThrSerSerIleGly-48 61-AspIleGlyArgSerLeuLysGlnMetLysGluGlnGlyAlaGluIleAspLeu-78 89-TyrAspGlyLysGluIleLysMetThrGluGluGlnAlaGln-102 109-LeuGlnGluGlnGlnAlaLysAlaValGluLysHisLysAlaAspAlaLysAlaAsnLysGluLysGlyGlu AlaPheLeuLysGluAsnAlaAlaLysAspGlyValLysThrThrAlaSerGlyLeu-151 154-LysIleThrLysGlnGlyGluGlyLysGlnProThrLysAspAspIleVal-170 173-GluTyrGluGlyArgLeuIleAsp-180 183-ValPheAspSerSerLysAlaAsnGlyGly-192 210-GlnLeuLeuLysGluGlyGlyGlu-217 224-SerAsnLeuAlaTyrArgGluGlnGlyAlaGlyAspLysIleGlyProAsnAla-241 253-GlyAlaProGluAsnAlaProAlaLysGlnProAla-264 266-ValAspIleLysLysValAsn-272 Hydrophilic Regions - Hopp-Woods 21-CysGlyLysLysGluAlaAlaPro-28 30-SerAlaSerGluProAlaAla-36 40-AlaGlnGlyAspThrΞerSer-46 61-AspIleGlyArgSerLeuLysGlnMetLysGluGlnGlyAlaGluIleAspLeu-78 89-TyrAspGlyLysGluIleLysMetThrGluGluGlnAlaGln-102 112-GlnGlnAlaLysAlaValGluLysHisLysAlaAspAlaLysAlaAsnLysGluLysGlyGluAlaPheLeu LysGluAsnAlaAlaLysAspGlyValLysThrThrAla-148 155-IleThrLysGlnGlyGluGlyLysGlnProThrLysAspAspIleVal-170 173-GluTyrGluGlyArgLeuIleAsp-180 185-AspSerSerLysAlaAsnGly-191 210-GlnLeuLeuLysGluGlyGlyGlu-217 227-AlaTyrArgGluGlnGlyAlaGlyAspLysIleGlyPro-239 253-GlyAlaProGluAsnAlaProAlaLysGlnProAla-264 266-ValAspIleLysLysValAsn-272 a577 AMPHI Regions - AMPHI 8-GlyLysIleValGlyAsn-13 24-AlaAlaSerTyrProLysProCysLysSerPheLysLeuAla-37 62-ThrValIleLysIleIle-67 104-AlaPheValValGlyIle-109 112-GlyMetPheAlaLeuPheGlyArg-119 144-GluLeuThrAlaProProAlaGln-151 Antigenic Index - Jameson-Wolf l-MetGluArgAsnGlyVal-6 14-ArgIleLeuArgMetSerSerGluHisAla-23 26-SerTyrProLysProCysLysSerPheLys-35 44-ArgSerCysProGlyGly-49 88-LeuProGlyGlnLysPheAspLeu-95 121-LeuSerLeuArgGlyGluAsnGlyArgLeuArgAlaGluValLysLysAsnAlaArgLeuThrGlyLysGlu LeuThrAlaProProAlaGlnAsnAlaProGluSerAlaLysGlnPro-160 Hydrophilic Regions - Hopp-Woods l-MetGluArgAsnGlyVal-6 14-ArgIleLeuArgMetSerSerGluHisAla-23 29-LysProCysLysSerPheLys-35 121-LeuSerLeuArgGlyGluAsnGlyArgLeuArgAlaGluValLysLysAsnAlaArgLeuThrGlyLysGlu LeuThr-146 152-AsnAlaProGluSerAlaLysGlnPro-160 a578 AMPHI Regions - AMPHI 10-PheAlaAspPhePheLysAspPheAlaProGlnPheGlyGlyPheGlnAsn-26 34-AspPhePheAlaAlaPheLeuGlyGlyLeuGlu-44 71-AsnThrAspAlaAlaArgPhe-77 Antigenic Index - Jameson-Wolf 2-GlyLysLeuAspIle-6 13-PhePheLysAspPheAlaProGlnPheGlyGly-23 43-LeuGluGlyAspValGlyAsnThrAla-51 71-AsnThrAspAlaAlaArgPheAla-78 88-HisAsnGlnAsnIleGlnThrArgAsnAspPheArgLeuGluArgGlyGlyValGly-106 Hydrophilic Regions - Hopp-Woods 2-GlyLysLeuAspIle-6 43-LeuGluGlyAspValGlyAsn-49 73-AspAlaAlaArgPheAla-78 92-IleGlnThrArgAsnAspPheArgLeuGluArgGlyGlyVal-105 a579 AMPHI Regions - AMPHI 6-PheAspPheLeuHisLeuIleSerAlaSerGlyTrpGluHisLeuAlaGlu-22 49-ValAlaValMetArg-53 66-IleSerPheLeuCysAsn-71 115-LeuSerAsnPheAla-119 129-ProPheLysValGlyAspPheIleArgValGlyGlyPheGluGlyTyrValArgGluIleLys-149 258-GlnValValGluAsnLeuArg-264 Antigenic Index - Jameson-Wolf 110-SerLeuLysAspGlnLeuSer-116 128-ArgProPheLysVal-132 136-IleArgValGlyGlyPheGluGlyTyrValArgGluIleLysMet-150 154-SerLeuArgThrThrAspAsnGluGluValValLeu-165 175-IleValAsnArgSerThrLeu-181 198-LeuLysValAlaLysGluAlaValLeu-206 216-ValGlnAsnGluGluArgGlnAla-223 231-GlyAspAsnAlaIle-235 244-AsnGluAlaAspArgTrpThrLeu-251 253-CysAspLeuAsnGluGlnValValGluAsnLeuArgLysValAsn-267 271-ProPheProGlnArgAspIleHis-278 Hydrophilic Regions - Hopp-Woods 110-SerLeuLysAspGlnLeu-115 144-TyrValArgGluIleLysMet-150 155-LeuArgThrThrAspAsnGluGluValVal-164 198-LeuLysValAlaLysGluAlaValLeu-206 216-ValGlnAsnGluGluArgGlnAla-223 244-AsnGluAlaAspArgTrp-249 254-AspLeuAsnGluGlnValValGluAsnLeuArgLysValAsn-267 273-ProGlnArgAspIleHis-278 a580 AMPHI Regions - AMPHI 47-ProValSerAlaSerLys-52 54-SerLeuValLysProLeuSerGlnProLeuAla-64 Antigenic Index - Jameson-Wolf l-MetAspSerProLysValGlyCysGly-9 48-ValSerAlaSerLys-52 66-AlaArgProGluAlaAlaHis-72 81-ArgProGluAlaLeuAlaAspAsnSerValSerProThrHisAlaThrSerGlyGluVal-100 Hydrophilic Regions - Hopp-Woods l-MetAspSerProLysVal-6 66-AlaArgProGluAlaAlaHis-72 81-ArgProGluAlaLeuAla-86 96-ThrSerGlyGluVal-100 a581 AMPHI Regions - AMPHI 43-SerHisPheIleSerLeu-48 56-ArgGluCysPheValGlyPhe-62 76-AlaThrAlaPheGlyArgIleAsnGln-84 91-ValHisGlyPheLeuThrThrPheAla-99 Antigenic Index - Jameson-Wolf 8-GlyGlnThrGlyIleGluGlnAsnThrPheCysArgArgGlyPheThrArgIleAspMetGlyGlyAsnThrAs pVal-33 35-ValGlnAlaAspArgGlyLeuThrSer-43 49-SerLysLeuGluThrGluValArgGluCysPhe-59 98-PheAlaGlyArgIleAsnProAlaHisCysGlnSerGlnThrAla-112 Hydrophilic Regions - Hopp-Woods 35-ValGlnAlaAspArgGlyLeu-41 49-SerLysLeuGluThrGluValArgGlu-57 a582 AMPHI Regions - AMPHI 27-ThrAspAsnValThrArgLeuAla-34 65-ValArgSerSerLeu-69 91-GlyGluThrAlaAspIleTyrThrProLeuSer-101 139-GlySerProThrArg-143 169-IleAlaGluAspLeuPhe-174 246-SerArgSerTrpAsnArgIleTyrAlaMet-255 263-LeuThrValIleProArgValTrpValArgAlaPheAspGlnSer-277 286-IleAlaAspTyrMetGlyTyr-292 334-LeuLysGlyValValArgGlyPheHisGlyTyrGlyGlu-346 Antigenic Index - Jameson-Wolf 26-LeuThrAspAsnValThr-31 34-AlaCysTyrAspArg-38 44-LeuProSerSerAlaGlyGlnGluGlyGlnGluSerLysAla-57 63-GluThrValArgSerSerLeuAspLysGlyGluAla-74 77-ValValGluLysGlyGlyAspAlaLeuProAlaAspSerAlaGlyGluThrAlaAsp-95 105-AspLeuAspLysAsnAspLeuArgGly-113 115-LeuGlyValArgGluHisAsnProMetTyr-124 131-AsnAsnSerProAsnTyrAlaProGlySerProThrArgGlyThrThrValGlnGluLysPheGlyGlnGln LysArgAlaGluThrLysLeu-161 165-PheLysSerLysIleAlaGluAspLeuPheLysThrArgAla-178 183-GlyTyrThrGlnArgSerAspTrpGlnIleTyrAsnGlnGlyArgLysSerAlaProPheArgAsnThrAsp TyrLysPro-209 216-ProValLysAlaAspLeuProPheGlyGlyArgLeuArgMet-229 237-GlnSerAsnGlyGlnSerArgProGluSerArgSerTrpAsn-250 273-AlaPheAspGlnSerGlyAspLysAsnAspAsnProAspIleAlaAsp-288 291-GlyTyrGlyAspValLysLeuGlnTyrArgLeuAsnAspArgGlnAsnVal-307 312-ArgTyrAsnProLysThrGlyTyr-319 330-IleLysGlyLysLeuLysGlyValVal-338 342-HisGlyTyrGlyGluSerLeuIleAspTyrAsnHisLysGlnAsnGly-357 365-AsnAspLeuAspGlyIle-370 Hydrophilic Regions - Hopp-Woods 48-AlaGlyGlnGluGlyGlnGluSerLysAla-57 63-GluThrValArgSerSerLeuAspLysGlyGluAla-74 79-GluLysGlyGlyAspAlaLeuPro-86 88-AspSerAlaGlyGluThrAlaAsp-95 105-AspLeuAspLysAsnAspLeuArgGly-113 115-LeuGlyValArgGluHisAsn-121 140-SerProThrArgGlyThrThrValGlnGluLysPheGlyGlnGlnLysArgAlaGluThrLysLeu-161 165-PheLysSerLysIleAlaGluAspLeuPheLysThrArgAla-178 195-GlnGlyArgLysSerAlaProPheArgAsnThrAspTyrLysPro-209 225-GlyArgLeuArgMet-229 239-AsnGlyGlnSerArgProGluSerArgSerTrp-249 274-PheAspGlnSerGlyAspLysAsnAspAsnProAspIleAlaAsp-288 293-GlyAspValLysLeu-297 299-TyrArgLeuAsnAspArgGlnAsn-306 332-GlyLysLeuLysGlyValVal-338 352-AsnHisLysGlnAsn-356 a583 AMPHI Regions - AMPHI ll-HisLeuAlaPheCysAlaPheCysGlyIle-20 28-ArgLeuHisAsnArgMetTyrAsnAlaAlaAlaAlaArg-40 58-ValThrAspAlaGln-62 66-SerLysAsnGlyAspLysGlnIle-73 75-AspThrHisProGlnPro-80 117-GlyTyrAlaGlyTyrCysAspGln-124 140-AspAsnGlyGlyAsnHisThrAsp-147 162-GlyTyrGlyGlnCysGlnAsnGlnGlyAla-171 Antigenic Index - Jameson-Wolf 24-ThrAlaGlyAsnArgLeuHisAsnArgMetTyr-34 41-GlyIleGlyArgGlyAsnGlySerGlnGlnGlnPheGlyLysSerGluThrValThrAspAlaGlnArgPheS erSerLysAsnGlyAspLysGlnlleSerAspThrHisProGlnProCysPheGluGlnThrAlaArgAsnHisAs nCysAspGlyAsnGlnProAsnGlnArglleGlyGluArgThrGlnArglleAlaHisArgArgThrArgPheVal GlyGlyTyrAlaGlyTyrCysAspGlnProAspGlyAsnAsnArgGlnArgThrGlnArgHisGlyLeuAlaAspA snGlyGlyAsnHisThrAspLysHisGlyGlnGlnArgProSerLeuArgLeuAspProValGlyTyrGlyGlnCy sGlnAsnGlnGlyAlaGlnTyrCysGlyAsnGlyGluGlyTyrArgPhe-182 190-AspLeuArgLysLysAspArgProGluLysSerGluLys-202 Hydrophilic Regions - Hopp-Woods 27-AsnArgLeuHisAsn-31 41-GlyIleGlyArgGlyAsnGlySer-48 51-GlnPheGlyLysSerGluThrValThrAspAlaGlnArgPheSerSerLysAsnGlyAspLysGlnIleSerA spThrHisPro-78 84-GlnThrAlaArgAsnHisAsnCysAspGlyAsnGlnProAsnGlnArgIleGlyGluArgThrGlnArgIleA laHisArgArgThrArgPhe-114 123-AspGlnProAspGlyAsnAsnArgGlnArgThrGlnArg-135 137-GlyLeuAlaAspAsnGlyGlyAsnHisThrAspLysHisGlyGlnGlnArgProSerLeuArgLeuAspPro -160 178-GluGlyTyrArgPhe-182 190-AspLeuArgLysLysAspArgProGluLysSerGluLys-202 a584-2 AMPHI Regions - AMPHI 28-GluPheSerGluSerAlaGlyValGluAlaValGlnAspThrMet-42 60-AlaGluPheValLysLysPheAsnAsnPheThrArgLys-72 116-PheAspAlaLeuAsnArgPheIleAlaAspVal-126 148-IleAspGlnValSerLysAsp-154 166-LeuAlaGlyValLeuGly-171 186-GlySerHisIleAla-190 196-GlnAlaLysMetLeuArgAlaMet-203 Antigenic Index - Jameson-Wolf 50-AlaGluGlyArgAspLysAsnAlaVal-58 61-GluPheValLysLysPheAsnAsnPheThrArgLysSerLysAsnGlySerPheLysThrGluLeuValSerA rgSerAlaMetProArgTyrGlnTyrThrAsnGlyArgArglleGlnThrGlyTrpGluGluArgAlaGluPheLy sValGluGlyArgAsnPheAspAla-118 138-HisValSerArgGluArgArgAsnGluValIleAspGlnValSerLysAspAlaValLeu-157 159-PheLysAlaArgAlaGluLysLeuAla-167 189-IleAlaGlyGlyGly-193 210-AsnMetGluGlyAlaAspSerAlaAlaProGlyValGluGluIleSer-225 Hydrophilic Regions - Hopp-Woods 50-AlaGluGlyArgAspLysAsnAlaVal-58 67-AsnAsnPheThrArgLysSerLysAsnGlySerPheLysThrGluLeuValSer-84 95-AsnGlyArgArgIleGlnThrGlyTrpGluGluArgAlaGluPheLysValGluGlyArgAsnPheAspAla- 118 138-HisValSerArgGluArgArgAsnGluValIleAspGlnValSerLysAspAlaValLeu-157 159-PheLysAlaArgAlaGluLysLeuAla-167 210-AsnMetGluGlyAlaAspSerAlaAlaProGlyValGluGluIleSer-225 a585 AMPHI Regions - AMPHI 6-ArgIlePheAlaThrPheCysAlaValIleValCys-17 46-ThrThrLeuMetGlySerIleIleSer-54 65-ArgGluIleLeuThrGluTrpLysAsp-73 93-HisArgTyrIleAspSer-98 133-LysAspTrpAspLysLeuGlnAlaArgArg-142 153-ProLeuAlaProIleTrp-158 178-LeuAlaGlyAsnIleAlaLysProIleArgIleLeuGlyAsnGlyMetAspArgValAla-197 223 -PheAspLysMetValGluLysLeuGluLysLeuVal-234 247-GluMetArgSerPro-251 255-MetGlnAlaIleValGlyLeuIle-262 273-LeuLysArgLeuGluGly-278 353-LeuTyrArgAlaPheAspAsnValIleArgAsnAlaValAsn-366 430-IleIleGluGlnHisCysGlyLysIleIleAlaGlu-441 Antigenic Index - Jameson-Wolf 36-AsnGlnPheAsnGlnArgArgThr11eGlu-45 56-PheArgAlaArgGlyAspAlaGlyAlaArgGluIleLeuThrGluTrpLysAspSerProValSer-77 84-GlnGlyAspGluLysLysAspIleLeu-92 97-AspSerTyrThrIleGluArgAlaArgLeu-106 120-GluTyrAspArgPheGlyGlu-126 133-LysAspTrpAspLysLeuGlnAlaArgArgLeuProSerPro-146 189-LeuGlyAsnGlyMetAspArgValAlaAsnGlyGluLeuGluThrArgIle-205 207-GlnGlnValAspAspArgAspAspGluLeuSer-217 225-LysMetValGluLysLeuGluLysLeuValAlaLysGluArgHisLeu-240 246-HisGluMetArgSerProLeuAla-253 264-AlaGlnProGlnLysGlnGluGlnTyrLeuLysArgLeuGluGlyGluLeuThrArgMetAspThrLeuAla -287 294-SerArgLeuGluThrSerAsnMetAlaLeuGluLysGluSerLeuLys-309 317-LeuValGluAspAsnGlnSerIleAlaGlnLysAsnGlyGln-330 335-SerAlaAspGlyLysIleProGluAsnThr-344 367-TyrSerProGluGlySerThr-373 377-AsnIleGlyGlnAspHisLysHis-384 388-AspValThrAspAsnGlyProGlyValAspGluMetGln-400 409-TyrArgAlaAspSerSerAlaAsnLysProGlyThrGly-421 432-GluGlnHisCysGlyLysIleIleAlaGluAsnIleLysProAsnGlyLeuArg-449 453-IleLeuProLysLysLysThrGlySerLysThrGluLysSerAlaAsn-468 Hydrophilic Regions - Hopp-Woods 37-GlnPheAsnGlnArgArgThrIleGlu-45 56-PheArgAlaArgGlyAspAlaGlyAlaArgGluIleLeuThrGluTrpLysAspSerProVal-76 84-GlnGlyAspGluLysLysAspIleLeu-92 100-ThrIleGluArgAlaArgLeu-106 120-GluTyrAspArgPheGlyGlu-126 133-LysAspTrpAspLysLeuGlnAlaArgArgLeuPro-144 192-GlyMetAspArgValAlaAsnGlyGluLeuGluThrArgIle-205 207-GlnGlnValAspAspArgAspAspGluLeuSer-217 225-LysMetValGluLysLeuGluLysLeuValAlaLysGluArgHisLeu-240 246-HisGluMetArgSerProLeu-252 265-GlnProGlnLysGlnGluGlnTyrLeuLysArgLeuGluGlyGluLeuThrArgMetAspThrLeuAla-28 7 294-SerArgLeuGluThr-298 302-AlaLeuGluLysGluSerLeuLys-309 317-LeuValGluAspAsnGlnSerIleAlaGlnLysAsnGlyGln-330 336-AlaAspGlyLysIleProGlu-342 389-ValThrAspAsnGlyProGlyValAspGluMetGln-400 410-ArgAlaAspSerSerAlaAsnLysProGlyThr-420 438-IleIleAlaGluAsnIleLys-444 454-LeuProLysLysLysThrGlySerLysThrGluLysSerAlaAsn-468 a586 AMPHI Regions - AMPHI 12-AspAsnPheLysTyrPheTrpLysThr-20 30-IleLeuAlaAlaLeuGly-35 56-ValLeuAlaAsnIleValGluLysAlaGlnAsnLysAlaPro-69 80-LeuGlnGlnSerTyrProHisSerIleSer-89 177-SerGlnGluAlaLeuLysAsnTyrGlyGlnAlaLeuGluLysMetProGlnAspSerValGlyArg-198 Antigenic Index - Jameson-Wolf 4-HisLeuGluGluGlnGlnGluLeuAspAsn-13 43-GlnAsnArgAlaAlaSerGlnAsnGlnGluAla-53 60-IleValGluLysAlaGlnAsnLysAlaProGlnSerGluIleAsnAlaGluLeuAlaLysLeuGlnGln-82 100-ThrGluPheAspAlaGlnArgTyrAspValAlaGluGly-112 118-LeuSerAsnGlnLysAspSerLeu-125 140-GlnGlnLysLysTyrAspAla-146 153-ThrProValGluAlaAspPhe-159 164-MetGluThrLysGlyAspVal-170 173-AlaGlnGlyLysSerGlnGluAlaLeuLysAsnTyrGlyGlnAlaLeuGluLysMetProGlnAspSerVal GlyArgGluLeuVal-201 204-LysLeuAspSerLeuLys-209 Hydrophilic Regions - Hopp-Woods 4-HisLeuGluGluGlnGlnGluLeuAspAsn-13 45-ArgAlaAlaSerGlnAsnGlnGluAla-53 60-IleValGluLysAlaGlnAsnLysAlaProGlnSerGluIleAsnAlaGluLeuAlaLys-79 100-ThrGluPheAspAlaGlnArgTyrAspValAlaGluGly-112 120-AsnGlnLysAspSerLeu-125 140-GlnGlnLysLysTyrAspAla-146 153-ThrProValGluAlaAspPhe-159 164-MetGluThrLysGlyAspVal-170 174-GlnGlyLysSerGlnGluAlaLeuLys-182 187-AlaLeuGluLysMetProGlnAspSerValGlyArgGluLeuVal-201 204-LysLeuAspSerLeuLys-209 a587 AMPHI Regions - AMPHI 6-LeuProAlaLeuProAlaIleLeuProLeuSerAla-17 232-LysGlnProAspArgLeuAsp-238 Antigenic Index - Jameson-Wolf 27-AspIleMetThrAspLysGlyLysTrpLysLeuGluThr-39 44-LeuAsnSerGluAsnAsnArgAlaGluLeu-53 71-ThrGluIleGlnGluAsnGlySerAsnThr-80 95-GlyAsnThrAspIleTyrGlySerGlySer-104 108-HisGluGluArgLysLeuAspGlyAsnGlyLysThrArgAsnLysArgMetSerAsp-126 135-PheLeuLysAspAspLysAsnProAla-143 151-ThrValTyrGluLysSerArgAsnLysAlaSerSerGlyLysSer-165 187-TyrArglleAsnGlySerLysThrLeuSerSerAsnThrLysTyrLysAlaGly-204 217-AlaAsnAspArgIleSerLeuThrGlyGly-226 231-GlyLysGlnProAspArgLeuAspGlyLysLysGluSerAlaArgAsnThrSerThr-249 273-ValSerGlyGlnSerSerSerGluLeuLysPhe-283 Hydrophilic Regions - Hopp-Woods 27-AspIleMetThrAspLysGlyLysTrpLysLeu-37 47-GluAsnAsnArgAlaGluLeu-53 72-GluIleGlnGluAsnGlySerAsn-79 108-HisGluGluArgLysLeuAspGlyAsnGlyLysThrArgAsnLysArgMetSerAsp-126 135-PheLeuLysAspAspLysAsnPro-142 151-ThrValTyrGluLysSerArgAsnLysAlaSerSerGly-163 193-LysThrLeuSerSer-197 199-ThrLysTyrLysAla-203 217-AlaAsnAspArgIleSer-222 232 -LysGlnProAspArgLeuAspGlyLysLysGluSerAlaArgAsn-246 277-SerSerSerGluLeuLysPhe-283 a588 AMPHI Regions - AMPHI 52-GlnAspGlyArgAsnTyrThrGlySerPhe-61 99-GlyThrPheLysLys-103 Antigenic Index - Jameson-Wolf 25-SerTyrGlnGluProGlyCysThrTyrGluGlyAspValGlyLysAspGlyLysProAlaGlyLysGlyThrT rpArgCysGlnAspGlyArgAsnTyrThrGlySerPheLysAsnGlyLysPheAspGlyGlnGly-70 80-IlePheIleGluProPheAsnSerAspSerThrLysPheArg-93 lOO-ThrPheLysLysGlyLeuAlaHisGlyArgPheThrValSerGlnAsnGlyGluThr-118 124-CysGluAsnGlyMetIleLysGluValLysLeuProLysAsnLys-138 Hydrophilic Regions - Hopp-Woods 33-TyrGluGlyAspValGlyLysAspGlyLysProAlaGly-45 47-GlyThrTrpArgCysGlnAspGlyArgAsnTyr-57 61-PheLysAsnGlyLysPheAspGly-68 85-PheAsnSerAspSerThrLysPheArg-93 100-ThrPheLysLysGlyLeuAla-106 124-CysGluAsnGlyMetIleLysGluValLysLeuProLysAsnLys-138 a589 AMPHI Regions - AMPHI 18-AlaSerArgIleGluLysValLeu-25 54-ValAlaAspIleAlaLysIleIleGluLys-63 103-MetValGlyMetMet-107 128-LeuAlaSerValValGlnLeuTrp-135 155-MetAspValLeuValThrIle-161 198-PheValSerLeuGlyLysPheLeuGluHisArg-208 230-ValGlnArgAspGlyGlu-235 245-GlnIleGlyAspLeuIleArg-251 315-LeuGlyAspMetMetAsnAlaLeuSerGluAlaGln-326 330-AlaProIleAlaArgValAlaAspLys-338 349-GlyIleAlaLeuLeuThrPheIleAlaThr-358 396-MetGlyLysAlaVal-400 471-IleValSerAlaAlaGln-476 482-IleProThrAlaGln-486 502-GlyAlaGlyLeuValLys-507 539-LysProIleGlyAlaPheAlaLeuAlaAspAlaLeuLys-551 553-AspThrAlaGluAlaIleGlyArgLeu-561 603-GluValGlnLysLeuLysAlaAla-610 617-ValGlyAspGlyIleAsnAspAlaPro-625 640-AlaAspValAlaGluHisThr-646 653-GlnHisSerValAsnGlnLeuAlaAspAlaLeuSer-664 680-AlaPhePheTyrAsnIleLeu-686 Antigenic Index - Jameson-Wolf l-MetGlnGlnLysValArgPheGlnIleGluGlyMetThr-13 17-CysAlaSerArgIleGluLysValLeuAsnLysLysAspPheValGluSer-33 39-AlaSerGluGluAlaGlnValValPheAspAspSerLysThrSerVal-54 59-LysIleIleGluLysThrGlyTyrGlyAlaLysGluLysThrGluAspThrLeuProGlnProGluAlaGluH is-83 114-ThrArgHisAspTrp-118 148-IleLysGlyGlyLeu-152 205-LeuGluHisArgThrLysLysSerSerLeuAsn-215 228-ValAsnValGlnArgAspGlyGluTrpArg-237 253-AsnHisGlyGluArgIleAlaAla-260 262-GlyIleIleGluSerGlySerGlyTrpAlaAspGluSerHisLeuThrGlyGluSerAsnProGluGluLys LysAlaGlyGly-289 298-ThrGluGlySerVal-302 323-SerGluAlaGlnGlySerLysAlaProIle-332 334-ArgValAlaAspLysAlaAla-340 361-IleLysGlyAspTrp-365 396-MetGlyLysAlaValLys-401 409-AlaAlaAlaMetGluGluAlaAlaHis-417 422-ValLeuAspLysThrGlyThrLeuThrGluGlyLysProGlnVal-436 443-ProAspSerGlyPheAspGluAspAlaLeu-452 459-ValGluGlnAsnAla-463 498-AlaGluValLysGlyAlaGlyLeu-505 507-LysAlaGlyLysAlaGluPheAla-514 520-LysPheSerAspGlyVal-525 535-SerValAsnGlyLysProIle-541 548-AspAlaLeuLysAlaAspThrAlaGluAlaIleGlyArgLeuLysLysHisAsnIle-566 572-SerGlyAspAsnGlnGlyThrValGluTyrValAla-583 593-GlyAsnMetSerProArgAspLysAlaAlaGluValGlnLysLeuLysAlaAlaGly-611 617-ValGlyAspGlylleAsnAspAla-624 636-MetLysGlyGlyAlaAspValAlaGlu-644 668-AlaThrLeuLysAsnIleLys-674 715-AsnAlaLeuArgLeuLysArgValLysIleAsp-725 Hydrophilic Regions - Hopp-Woods l-MetGlnGlnLysValArgPheGlnIle-9 19-SerArgIleGluLysValLeuAsnLysLysAspPheValGlu-32 39-AlaSerGluGluAlaGlnValValPheAspAspSerLysThrSerVal-54 64-ThrGlyTyrGlyAlaLysGluLysThrGluAspThrLeuProGlnProGluAlaGluHis-83 205-LeuGluHisArgThrLysLysSerSerLeu-214 229-AsnValGlnArgAspGlyGluTrpArg-237 253-AsnHisGlyGluArgIleAlaAla-260 262-GlyIleIleGluSer-266 270-TrpAlaAspGluSerHisLeuThrGlyGluSerAsnProGluGluLysLysAlaGlyGly-289 323-SerGluAlaGlnGlySerLysAlaProIle-332 334-ArgValAlaAspLysAlaAla-340 409-AlaAlaAlaMetGluGluAlaAlaHis-417 422-ValLeuAspLysThrGlyThr-428 430-ThrGluGlyLysProGln-435 445-SerGlyPheAspGluAspAlaLeu-452 459-ValGluGlnAsnAla-463 498-AlaGluValLysGly-502 507-LysAlaGlyLysAlaGluPheAla-514 548-AspAlaLeuLysAlaAspThrAlaGluAlaIleGlyArgLeuLysLysHisAsnIle-566 573-GlyAspAsnGlnGly-577 596-SerProArgAspLysAlaAlaGluValGlnLysLeuLysAlaAlaGly-611 638-GlyGlyAlaAspValAlaGlu-644 668-AlaThrLeuLysAsnIleLys-674 717-LeuArgLeuLysArgValLysIleAsp-725 a590 AMPHI Regions - AMPHI 77-TyrLeuProAspAsnLeuLysThrValLeuGluGlnProValThrLeuValAsnHisIleThrHis-98 100-ProPheAlaGlyGlyPhe-105 123-LysValLeuGluArgPhePhe-129 132-GlnValProValSerLeu-137 177-TyrGlnLysGlyPheLysSerTyrArgAsnGly-187 214-ThrSerAspGlyIleAsnProLeu-221 248-AsnGluLeuValAsnLeuVal-254 331-LysArgLysPheAlaArgIle-337 420-LysMetLeuGluAsp-424 450-Aspl1eAsnGluThrLeuArgLeuMe -458 460-AspSerThrValGln-464 Antigenic Index - Jameson-Wolf l-Me LysLysProLeu-5 26-LysAlaGluGluSerLeuThrGlnGlnGlnLysIleLeuGln-39 48-SerHisGlnTyrGluArgGlyTrpPheThrSerThrGluThrThrValIleArgLeuLysProGluLeu-70 75-GlnLysTyrLeuProAspAsnLeuLysThrValLeu-86 113-ThrGluPheLysTyrAlaProGluThrGluLysValLeuGlu-126 128-PhePheGlyLysGlnVal-133 144-AsnGlySerGlyLysMetGluVal-151 157-AspTyrGluGluLeuSerGly-163 175-ThrValTyrGlnLysGlyPheLysSerTyrArgAsnGlyTyrAspAlaPro-191 196-LysLeuAlaAspLysGlyAspAlaAlaPheGlu-206 208-ValHisPheAspSerGluThrSerAspGlyIleAsn-219 233-PheSerLeuGluTrpLysGluGlyValAspTyr-243 264-AsnProAsnGlySerIleAlaProSerLysIleGluValGly-277 281-PheSerThrLysThrGlyGluSerGlyAla-290 292-IleAspSerGluGlyGlnPheArgPhe-300 305-TyrGlyAspGluLysTyrGlyPro-312 330-LeuLysArgLysPheAlaArgIleSerAlaLysLysMetThrGluGluGlnIleArgAsnAspLeu-351 355-ValLysGlyGluAlaSerGly-361 366-AsnProValLeuAsp-370 378-LeuProSerGlyLysIleAspValGlyGly-387 389-IleMetPheLysAspMetLysLysGluAspLeuAsnGln-401 406-LeuLysLysThrGluAlaAspIleArgMet-415 437-AsnAlaGluAspGluAlaGluGlyArgAlaSerLeuAspAspIleAsnGluThrLeu-455 466-MetAlaArgGluLysTyr-471 475-AsnGlyAspGlnIleAsp-480 485-LeuLysAsnAsnGlnLeuLysLeuAsnGlyLysThrLeuGlnAsnGluProGluProAspPheAspGluGly GlyMetValSerGluProGlnGln-516 Hydrophilic Regions - Hopp-Woods l-MetLysLysProLeu-5 26-LysAlaGluGluSerLeuThrGln-33 62-ThrValIleArgLeuLysProGluLeu-70 77-TyrLeuProAspAsnLeuLysThrValLeu-86 113-ThrGluPheLysTyrAlaProGluThrGluLysValLeuGlu-126 147-GlyLysMetGluVal-151 157-AspTyrGluGluLeuSerGly-163 180-GlyPheLysSerTyrArgAsnGlyTyr-188 196-LysLeuAlaAspLysGlyAspAlaAlaPheGlu-206 208-ValHisPheAspSerGluThrSerAspGly-217 233-PheSerLeuGluTrpLysGluGlyValAspTyr-243 272-SerLysIleGluValGly-277 292-1leAspSerGluGlyGlnPhe-298 306-GlyAspGluLysTyrGlyPro-312 330-LeuLysArgLysPheAlaArgIleSerAlaLysLysMetThrGluGluGlnIleArgAsnAspLeu-351 355-ValLysGlyGluAla-359 381-GlyLysIleAspValGlyGly-387 389-IleMetPheLysAspMetLysLysGluAspLeuAsn-400 406-LeuLysLysThrGluAlaAspIleArgMet-415 437-AsnAlaGluAspGluAlaGluGlyArgAlaSerLeuAspAspIleAsnGluThrLeu-455 466-MetAlaArgGluLysTyr-471 486-LysAsnAsnGlnLeuLysLeuAsnGly-494 496-ThrLeuGlnAsnGluProGluProAspPheAspGluGlyGlyMetValSerGluProGlnGln-516 a591 AMPHI Regions - AMPHI 6-AlaPheIlePheAla-10 17-LeuHisGluPheGlyHisTyrIleValAla-26 61-LeuGlyGlyTyrValLysMetValAsp-69 143-GlyAspLysIleGlnSerValAsnGlyThrProValAlaAspTrp-157 181-SerGlyAlaGlnThrValArgThrIleAspAlaAlaGlyThrProGluAlaGlyLysIleAlaLys-202 218-AlaGlyGlyValGluLys-223 234-ProGlyAspArgLeu-238 245-ProIleAlaSerTrpGlnGluTrpAlaAsnLeuThrArg-257 304-AlaTrpAspAlaGlnIleArg-310 313-TyrArgProSerValValArgAlaPheGly-322 324-GlyTrpGluLysThrValSerHis-331 335-ThrLeuLysPhePheGlyLysLeuIle-343 351-HisIleSerGlyProLeuThrIleAla-359 373-TyrLeuGluPheLeuAlaLeu-379 Antigenic Index - Jameson-Wolf 44-PhePheThrArgLysArgGlyAspThrGlu-53 68-ValAspThrArgGluGlyGluValSerGluAlaAspLeu-80 84-PheAspLysGlnHisProAlaLysArg-92 129-ValGluProAspThrIleAla-135 139-GlyPheGlnSerGlyAspLysIleGlnSer-148 157-TrpGlySerAlaGln-161 187-ArgThrIleAspAlaAlaGlyThrProGluAlaGlyLysIleAlaLysAsnGlnGly-205 219-GlyGlyValGluLysGlySerProAlaGluLysAlaGlyLeuLysProGlyAspArgLeuThrAlaAlaAsp GlyLysProIle-246 254-AsnLeuThrArgGlnSerProGlyLysLysIle-264 268-TyrGluArgAlaGlyGlnThrHisThrAlaAspIleArgProAspThrValGluGlnProAspHisThrLeu -291 295-ValGlyLeuArgProGlnProAspArgAlaTrp-305 307-AlaGlnIleArgArgSerTyrArgProSerVal-317 327-LysThrValSerHisSer-332 343-IleSerGlyAsnAla-347 362-AlaGlyGlnSerAla-366 408-IleArgGlyLysProLeuGlyGluArgValGln-418 Hydrophilic Regions - Hopp-Woods 44-PhePheThrArgLysArgGlyAspThr-52 68-ValAspThrArgGluGlyGluValSerGluAlaAspLeu-80 84-PheAspLysGlnHisProAlaLysArg-92 129-ValGluProAspThrIleAla-135 139-GlyPheGlnSerGlyAspLysIleGlnSer-148 193-GlyThrProGluAlaGlyLysIleAlaLys-202 220-GlyValGluLysGlySerProAlaGluLysAlaGlyLeuLysProGlyAspArgLeuThrAlaAlaAspGly LysPro-245 256-ThrArgGlnSerProGlyLysLysIle-264 268-TyrGluArgAlaGlyGln-273 277-AlaAspIleArgProAspThrValGluGlnProAsp-288 299-ProGlnProAspArgAlaTrp-305 308-GlnIleArgArgSerTyrArg-314 362-AlaGlyGlnSerAla-366 411-LysProLeuGlyGluArgValGln-418 a592 AMPHI Regions - AMPHI 6-PheGlyGlnIlePheSer-ll 21-GlyGlyLeuLeuGlyGlyLeuIle-28 50-AlaProAsnAlaAlaAlaAlaAla-57 65-GlnGlyMetIleGlnMetLeuGlyValPheValAsp-76 94-ProTyrGlyAspLeu-98 109-ValSerGlnValGlyGlnTrp-115 153-ThrAlaValPheArgMet-158 165-TyrPheGlyAlaValAla-170 185-IleMetAlaTrpIleAsnLeuValAlaIleLeuLeuLeuSer-198 Antigenic Index - Jameson-Wolf 35-GlyIleLysArgGlyLeuTyrSerAsnGluAlaGlyMetGlySerAlaProAsnAla-53 57-AlaGluValLysHisProValSer-64 93-GlnProTyrGlyAspLeuSerGly-100 137-AlaTyrAlaGluSerAsnVal-143 206-ArgAspTyrThrAlaLysLeuLysMetGlyLysAspProGluPheLysLeuSerGluHisProGlyLeuLys ArgArgIleLysSerAspValTrp-237 Hydrophilic Regions - Hopp-Woods 35-GlyIleLysArgGlyLeuTyr-41 57-AlaGluValLysHisProVal-63 212-LeuLysMetGlyLysAspProGluPheLysLeuSerGlu-224 226-ProGlyLeuLysArgArgIleLysSer-234 a593 AMPHI Regions - AMPHI 6-GlyLeuCysLysArgPheGlyGlyLysThr-15 41-SerThrLeuLeuAsnMetIleAlaGlyIleValArg-52 87-HisMetSerAlaLeuGlu-92 102-LysMetProLysAla-106 125-AlaHisArgLysProXxxLysLeuSerGlyGlyGlu-136 159-PheSerSerLeuAsp-163 165-HisLeuArgAspArgLeuArgArgMet-173 213-CysGlyThrProGluThrLeuValGlnThrProAlaGlyValGlnValAlaHisLeuMetGly-233 Antigenic Index - Jameson-Wolf 6-GlyLeuCysLysArgPheGlyGlyLysThrValAlaAsp-18 24-ValGlyArgGlyLysIle-29 33-LeuGlyArgSerGlyCysGlyLysSerThr-42 50-IleValArgProAspGlyGlyGlu-57 61-AsnGlyGluAsnIleThrArgMetProProGluLysArgArgIle-75 99-LysMetGlnLysMetProLysAlaGluAlaGluSer-110 119-ValGlyLeuGluAsnGluAlaHisArgLysProXxxLysLeuSerGlyGlyGluLysGlnArgLeuAlaLeu -142 157-GluSerPheSerSerLeu-162 164-ThrHisLeuArgAspArgLeuArgArgMetThrAlaGluArgIleArgLysGlyGlyIle-183 190-HisSerProGluGluAlaCysThrAlaAlaAspGluIleAlaVal-204 206-HisGluGlyLysIleLeuGlnCysGlyThrProGluThrLeu-219 233-GlyLeuProAsnThrAspAspAspArgHisIle-243 248-ValArgPheAspGlnAspGlyMetGluCysArgValLeuSer-261 263-ThrCysLeuProGluSer-268 291-GlyGluIleSerGlyAsnAspThrValArgIleHisIleGluAspArgGluIleValArgPheArg-312 Hydrophilic Regions - Hopp-Woods 6-GlyLeuCysLysArgPheGlyGly-13 25-GlyArgGlyLysIle-29 36-SerGlyCysGlyLys-40 51-ValArgProAspGlyGly-56 68-MetProProGluLysArgArgIle-75 99-LysMetGlnLysMetProLysAlaGluAlaGluSer-110 119-ValGlyLeuGluAsnGluAlaHisArgLysProXxxLysLeuSerGlyGlyGluLysGlnArgLeuAlaLeu -142 164-ThrHisLeuArgAspArgLeuArgArgMetThrAlaGluArgIleArgLysGlyGly-182 191-SerProGluGluAlaCysThrAlaAlaAspGluIleAlaVal-204 206-HisGluGlyLysIle-210 236-AsnThrAspAspAspArgHisIle-243 248-ValArgPheAspGlnAspGlyMetGluCysArgValLeuSer-261 291-GlyGluIleSerGly-295 297-AspThrValArgIleHisIleGluAspArgGluIleValArgPheArg-312 a594 AMPHI Regions - AMPHI 21-SerIleLeuArgLeu-25 108-AlaGlyArgGluCysGlnGluThrAlaAlaAla-118 138-AlaIleLysArgCysAsn-143 Antigenic Index - Jameson-Wolf l-MetGlyAlaAspThrAspGlyAspLysAspValArgLeuAsnArgThr-16 51-ValGluHisProAsnArgPhe-57 75-HisLeuAspGlySerThrGlyGly-82 86-PheArgArgGluLysThrGlyHisLysArgArgCysHisThrGlnCys-101 103-HisSerAlaArgAlaAlaGlyArgGluCysGlnGluThr-115 137-ArgAlaIleLysArgCysAsn-143 Hydrophilic Regions - Hopp-Woods l-MetGlyAlaAspThrAspGlyAspLysAspValArgLeuAsnArg-15 86-PheArgArgGluLysThrGlyHisLysArgArgCysHis-98 105-AlaArgAlaAlaGlyArgGluCysGlnGluThr-115 137-ArgAlaIleLysArgCysAsn-143 a595 AMPHI Regions - AMPHI 20-CysGlnProProGluAla-25 140-AlaAspLeuGluLysLeuSerGlnProLeuAla-150 157-GlnGlyGluValLysGluLeuVal-164 169-ThrPheThrGluAlaValLysAlaGlyAspIleGluLysAla-182 196-IleGluProIleAlaGluLeuPheSerGluLeuAspPro-208 224-AlaGlyPheThrGlyPheHisArg-231 243-SerGlyValLysGluIleAlaAlaLysLeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 274-ValGlyGlyAlaSerGluLeuIleGluGluValAlaGly-286 309-AspGlySerLysLysIleValAspLeuPheArgProLeu-321 337-PheLysGlnValAsnGluIleLeuAlaLys-346 351-AspGlyPheGluThrTyrAspLysLeuGlyGlu-361 366-AlaLeuGlnAlaSerIleAsnAlaLeuAlaGluAspLeuAlaGlnLeuArgGlyIleLeuGlyLeu-387 Antigenic Index - Jameson-Wolf 1-MetArgLysPheAsn-5 21-GlnProProGluAlaGluLysAlaAlaPro-30 32-AlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySer-44 50-AsnAspAsnAlaCysGluProMetGlu-58 70-1leLysAsnAsnSerGlyArgLysLeuGluTrpGluIle-82 87-MetValValAspGluArgGluAsnIleAla-96 98-GlyLeuSerAspLysMetThr-104 108-LeuProGlyGluTyrGluMet-114 120-ThrAsnProArgGlyLysLeuValValThrAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGlu LysLeuSer-146 158-GlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGlyAspIleGluLys AlaLysSerLeuPheAla-187 189-ThrArgValHisTyrGluArgIleGluProIle-199 204-SerGluLeuAspProValIleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGly-225 238-ValGluLysAspValSerGlyValLysGluIleAlaAla-250 252-LeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 269-ProProGlyLysValValGlyGlyAla-277 279-GluLeuIleGluGluValAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSer AspPheGlnAlaAsnValAspGlySerLysLysIleValAsp-316 322-11eGluThrLysAsnLysAlaLeuLeuGluLysThrAspThrAsnPheLysGlnValAsn-341 345-AlaLysTyrArgThrLysAspGlyPheGluThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeu-36 7 374-LeuAlaGluAspLeuAlaGln-380 Hydrophilic Regions - Hopp-Woods 1-MetArgLysPheAsn-5 21-GlnProProGluAlaGluLysAlaAlaPro-30 32-AlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySer-44 52-AsnAlaCysGluProMetGlu-58 72-AsnAsnSerGlyArgLysLeuGluTrpGluIle-82 87-MetValValAspGluArgGluAsnIle-95 99-LeuSerAspLysMetThr-104 110-GlyGluTyrGluMet-114 122-ProArgGlyLysLeuValVal-128 131-SerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuSer-146 158-GlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGlyAspIleGluLys AlaLysSerLeuPheAla-187 189-ThrArgValHisTyrGluArgIleGluProIle-199 204-SerGluLeuAspProValIleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGly-225 238-ValGluLysAspValSerGlyValLysGluIleAlaAla-250 252-LeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 279-GluLeuIleGluGluValAlaGly-286 288-LysIleSerGlyGluGluAspArgTyrSerHis-298 308-ValAspGlySerLysLysIleValAsp-316 322-11eGluThrLysAsnLysAlaLeuLeuGluLysThrAspThrAsnPhe-337 347-TyrArgThrLysAspGlyPheGluThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeu-367 374-LeuAlaGluAspLeuAlaGln-380 a596 AMPHI Regions - AMPHI 9-MetLeuArgValSerLysValVal-16 50-LeuArgIleMetAlaGlyValAspLys-58 87-ValArgGluGluValGluSerGlyLeuGlyGluValAlaAlaAlaGlnLysArgLeuGluGluValTyrAlaG luTyr-112 192-ProThrAsnHisLeuAsp-197 202-GluTrpLeuGluGlnPheLeuValArgPheProGly-213 295-AlaArgPheGluGluMetSerAsnTyr-303 322-LeuGlyAsnGluValIleGluPheValAsnValSerLysSerPhe-336 366-SerThrLeuPheLysMet-371 409-AspAsnIleAlaGlu-413 444-IleThrGlyGlnLeuSer-449 483-LeuArgAlaLeuGluAspAlaLeuLeuGluPheAla-494 Antigenic Index - Jameson-Wolf 16-ValProProGlnLysThrIleIleLysAspIleSer-27 41-LeuAsnGlyAlaGlyLysSerThrVal-49 54-AlaGlyValAspLysGluPheGluGlyGluAla-64 75-LeuProGlnGluProGluLeuAspProGluLysThrValArgGluGluValGluSerGlyLeu-95 99-AlaAlaAlaGlnLysArgLeuGluGluValTyr-109 112-TyrAlaAsnProAspAlaAspPheAspAlaLeuAlaGluGluGlnGlyArgLeuGlu-130 136-GlySerSerThrGlyGlyGlyAlaGluHisGluLeuGluIleAlaAlaAspAlaLeuArg-155 157-ProGluTrpAspAlaLysIleAspAsnLeuSerGlyGlyGluLysArgArgValAla-175 181-LeuSerLysProAspMet-186 190-AspGluProThrAsnHisLeuAspAlaGluSer-200 219-ThrHisAspArgTyrPhe-224 233-LeuGluLeuAspArgGlyHisGlyIleProTrpLysGlyAsnTyrSerSer-249 251-LeuGluGlnLysGluLysArgLeuGluAsnGluAlaLysSerGluAlaAlaArgValLysAlaMetLysGln GluLeuGluTrp-278 280-ArgGlnAsnAlaLysGlyArgGlnAlaLysSerLysAlaArgLeuAlaArgPheGluGluMetSerAsnTyr GluTyrGlnLysArgAsnGluThrGlnGlu-313 319-AlaGluArgLeuGlyAsnGluVal-326 333 -SerLysSerPheGlyAsp-338 359-GlyProAsnGlyAlaGlyLysSerThrLeu-368 373-AlaGlyLysGluGlnProAspSerGlyGluValLysIle-385 395-AspGlnSerArgGluGlyLeuGlnAsnAspLysThrValPhe-408 411-IleAlaGluGlyArgAspIleLeu-418 421-GlyGlnPheGluIleProAlaArgGlnTyrLeuGlyArgPheAsnPheLysGlySerAspGlnSerLysIle -444 446-GlyGlnLeuSerGlyGlyGluArgGlyArgLeuHisLeu-458 462-LeuLeuGlyGlyGlyAsn-467 471-LeuAspGluProSerAsnAspLeuAspValGluThr-482 501-SerHisAspArgTrpPhe-506 516-AlaCysGluGlyAspSerLysTrp-523 526-PheAspGlyAsnTyrGlnGluTyrGluAlaAspLysLysArgArgLeuGlyGluGluGlyThrLysProLys ArglleLysTyrLysProValThrArg-558 Hydrophilic Regions - Hopp-Woods 54-AlaGlyValAspLysGluPheGluGlyGluAla-64 77-GlnGluProGluLeuAspProGluLysThrValArgGluGluValGluSerGlyLeu-95 99-AlaAlaAlaGlnLysArgLeuGluGluValTyr-109 113-AlaAsnProAspAlaAspPheAspAlaLeuAlaGluGluGlnGlyArgLeuGlu-130 141-GlyGlyAlaGluHisGluLeuGluIleAlaAlaAspAlaLeuArg-155 157-ProGluTrpAspAlaLysIleAspAsn-165 167-SerGlyGlyGluLysArgArgValAla-175 181-LeuSerLysProAsp-185 190-AspGluProThrAsnHisLeuAspAlaGluSer-200 233-LeuGluLeuAspArgGlyHis-239 251-LeuGluGlnLysGluLysArgLeuGluAsnGluAlaLysSerGluAlaAlaArgValLysAlaMetLysGln GluLeuGluTrp-278 280-ArgGlnAsnAlaLysGlyArgGlnAlaLysSerLysAlaArgLeuAlaArgPheGluGluMetSerAsn-30 2 304-GluTyrGlnLysArgAsnGluThrGln-312 319-AlaGluArgLeuGlyAsnGluVal-326 373-AlaGlyLysGluGlnProAspSerGlyGluValLysIle-385 395-AspGlnSerArgGluGlyLeuGlnAsnAspLysThrValPhe-408 411-IleAlaGluGlyArgAspIleLeu-418 435-AsnPheLysGlySerAspGlnSerLysIle-444 449-SerGlyGlyGluArgGlyArgLeuHisLeu-458 472-AspGluProSerAsnAspLeuAspValGluThr-482 517-CysGluGlyAspSer-521 529-AsnTyrGlnGluTyrGluAlaAspLysLysArgArgLeuGlyGluGluGlyThrLysProLysArgIleLys Tyr-553 a597 AMPHI Regions - AMPHI 6-SerAsnSerLeuLysGlnLeuGlnGlu-14 45-TrpAspLysPheGlnLysLeu-51 68-GlnIleSerArgPheValSerGly-75 101-LeuArgTyrThrArgTyrValAsnAla-109 lll-AsnArgGluValValLysAspLeuGluLysGlnGln-122 132-IleAsnAsnGluLeuAlaArgLeuLysLys-141 144-AlaAsnValGlnSerLeu-149 157-AspAlaAlaGluGlnThrGlu-163 169-AlaLysIleAlaLysAspAlaArg-176 189-AsnLysLeuLeuSer-193 253-ProSerValMetGlyIleGlySerAlaAspGlyPheSerArgMetGlnGlyArgLeuLysLysProValAsp GlyValProThrGly-281 302-ProAlThrValGluSerIleAla-309 314-SerTyrAlaAspGluLeuAspGlyTyrGlyLys-324 336-SerIleTyrAlaGlyLeu-341 Antigenic Index - Jameson-Wolf 7-AsnSerLeuLysGlnLeuGlnGluGluArgIleArgGlnGluArgIleArgGlnGluArgIleArgGlnAlaAr gGlyAsnLeu-34 36-SerValAsnArgLysGlnArgGluAlaTrpAspLysPheGlnLysLeuAsnThrGluLeuAsnArgLeuLysT hrGluValAlaAla-64 74-SerGlyAsnTyrLysAsnSerGlnProAsn-83 91-AsnAlaGluProGlyGlnLysAsnArgPhe-lOO 107-ValAsnAlaSerAsnArgGluValValLysAspLeuGluLysGlnGlnLys-123 128-GlnGluGlnLysIleAsnAsnGluLeuAlaArgLeuLysLysIleGln-143 149-LeuLeuLysLysGlnGlyValThrAspAlaAlaGluGlnThrGluSerArgArgGlnAsnAlaLysIleAla LysAspAlaArgLysLeuLeuGluGlnLysGlyAsnGluGlnGlnLeu-188 191-LeuLeuSerAsnLeuGluLysLysLysAlaGluHisArgIleGlnAspAlaGluAlaLysArgLysLeuAla GluAlaArgLeuAlaAlaAlaGluLysAlaArgLysGluAlaAlaGlnGlnLysAlaGluAlaArgArgAlaGluM etSerAsnLeuThrAlaGluAspArgAsnIleGlnAlaProSer-254 259-GlySerAlaAspGlyPheSerArgMetGlnGlyArgLeuLysLysProValAspGlyValProThr-280 284-GlyGlnAsnArgSerGlyGlyAspVal-292 314-SerTyrAlaAspGluLeuAspGlyTyrGly-323 329-AspHisGlyGluAsnTyr-334 345-SerValGlyLysGlyTyr-350 354-AlaGlySerLysIleGlySerSerGlySerLeuProAspGlyGluGluGlyLeu-371 381-ValLeuAsnProSerSerTrp-387 Hydrophilic Regions - Hopp-Woods 7-AsnSerLeuLysGlnLeuGlnGluGluArgIleArgGlnGluArgIleArgGlnGluArgIleArgGlnAlaAr gGlyAsn-33 37-ValAsnArgLysGlnArgGluAlaTrpAspLysPheGlnLysLeuAsnThrGluLeuAsnArgLeuLysThrG luValAlaAla-64 77-TyrLysAsnSerGln-81 91-AsnAlaGluProGlyGlnLysAsnArgPhe-100 110-SerAsnArgGluValValLysAspLeuGluLysGlnGlnLys-123 128-GlnGluGlnLysIleAsnAsnGluLeuAlaArgLeuLysLysIleGln-143 149-LeuLeuLysLysGlnGlyValThrAspAlaAlaGluGlnThrGluSerArgArgGlnAsnAlaLysIleAla LysAspAlaArgLysLeuLeuGluGlnLysGlyAsnGluGlnGlnLeu-188 193-SerAsnLeuGluLysLysLysAlaGluHisArgIleGlnAspAlaGluAlaLysArgLysLeuAlaGluAla ArgLeuAlaAlaAlaGluLysAlaArgLysGluAlaAlaGlnGlnLysAlaGluAlaArgArgAlaGluMet-240 244-ThrAlaGluAspArgAsnIleGln-251 267-MetGlnGlyArgLeuLysLysProValAsp-276 286-AsnArgSerGlyGlyAspVal-292 315-TyrAlaAspGluLeuAspGlyTyrGly-323 356-SerLysIleGlySer-360 363-SerLeuProAspGlyGluGluGlyLeu-371 a601 AMPHI Regions - AMPHI 7-LeuValAspGluIleAspValProAsnIleGlyArg-18 26-AlaGlyIleProThrValPhe-32 42-GlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluLysIleArgAlaTyrG lyAlaLeu-68 70-MetGlyLeuIleSerAspValSerGluAlaAla-80 100-SerSerGlyLysThrValAsn-106 137-AlaAlaAlaValProGlyThrLeuValAsnLeuAlaAla-149 169-GlyAlaAlaAlaGlu-173 Antigenic Index - Jameson-Wolf 3-ProThrGlyAsnLeuValAspGluIleAspValProAsnIleGlyArgLeuLys-20 39-GlyTyrThrGlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluLysIleA rgAla-64 75-AspValSerGluAlaAlaAlaArgAlaHisThrPro-86 97-TyrThrAlaSerSerGlyLysThrValAsn-106 149-AlaGlyGlyGlyThrArgLysGluValArgPheGlyHisProSerGlyThrLeuArg-167 172-AlaGluCysGlnAspGlyGln-178 185-ValMetSerArgSerAlaArgValMet-193 198-ValArgValProGluAspCysPhe-205 Hydrophilic Regions - Hopp-Woods 7-LeuValAspGluIleAspVal-13 40-TyrThrGlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluLysIleArgA la-64 75-AspValSerGluAlaAlaAlaArgAlaHisThr-85 99-AlaSerSerGlyLysThrValAsn-106 151-GlyGlyThrArgLysGluValArgPhe-159 172-AlaGluCysGlnAsp-176 188-ArgSerAlaArgValMet-193 200-ValProGluAspCysPhe-205 a602 AMPHI Regions - AMPHI 7-AspLysAlaArgHis-ll 21-ValAsnArgHisGlyGln-26 54-ArgGlnIleAlaGlnIle-59 61-AlaGlyLeuHisValCysAsnSerVal-69 78-HisValIleValGluMetCysAlaTrpTyr-87 Antigenic Index - Jameson-Wolf 5-GlnCysAspLysAlaArgHisMe Arg-13 20-GlnValAsnArgHisGlyGlnThrGlyAsnCysGly-31 36-CysSerLeuGlnGlyAsnArgLysAlaGlnValPheAspThrAspLeuIleAspArgGlnIle-56 90-SerThrGlyGluTyr-94 99-GlnMetArgAspTyrIle-104 Hydrophilic Regions - Hopp-Woods 5-GlnCysAspLysAlaArgHisMetArg-13 20-GlnValAsnArgHisGlyGln-26 39-GlnGlyAsnArgLysAlaGlnValPheAsp-48 50-AspLeuIleAspArgGlnIle-56 a603 AMPHI Regions - AMPHI 158-ValMetAspGluLeuAsnAlaCysIlePro-167 172-HisAsnProAlaAsnIleSerGlyIleLeuAla-182 186-HisPheProGlyLeuProAsnValGly-194 199-SerPheHisGlnThrMetPro-205 212-AlaValProArgGluLeu-217 245-GlyLysProLeuGluAspIleArgMetIleIleAlaHis-257 260-AsnGlyAlaSerIleThrAlaIleLysAsnGlyLysSerVal-273 280-ThrProIleGluGly-284 299-TyrSerTyrLeuThrSer-304 324-LeuGlyIleSerGlu-328 330-SerAsnAspCysArg-334 357-ArgLeuAlaLysTyrIleAlaSerMet-365 393-ValSerTyrLeuAsp-397 Antigenic Index - Jameson-Wolf l-LeuSerSerArgArgArgGlyArgAsnAsnAspArgLysCysGlyIle-16 18-PheAlaGlnArgGlyArgLeuLysHisThrProProAsnAlaHisProPheSerAspAspProThrXxxLysL ysGlnProGlnThrThrArgArgAsnIleMetSer-53 63-GlySerSerSerLeuLysGlyAlaValIleAspArgLysSerGlySer-78 84-LeuGlyGluArgLeuThrThrProGluAla-93 96-ThrPheSerLysAspGlyAsnLysArgGlnValProLeuSerGlyArgAsnCysHis-114 124-GluLeuGluLysHisGluLeuHisAspArgIleGln-135 142-AlaHisGlyGlyGluLysTyrSerGlu-150 157-AlaValMetAspGluLeuAsn-163 203-ThrMetProGluArgAlaTyr-209 215-ArgGluLeuArgLysLysTyrAlaPheArgArgTyrGlyPheHisGlyThrSerMetArg-234 246-LysProLeuGluAspIleArg-252 258-LeuGlyAsnGlyAla-262 265-ThrAlaIleLysAsnGlyLysSerValAspThrSerMetGly-278 289-ThrArgCysGlyAspIleAspProGlyVal-298 311-AlaGlnValAspGluMetLeuAsnLysLysSerGly-322 327-SerGluLeuSerAsnAspCysArgThrLeuGluIleAlaAlaAspGluGlyHisGluGlyAlaArgLeu-34 9 380-GlyIleGlyGluAsnSerArgAsnIleArgAlaLysThr-392 403-IleAspThrLysAlaAsnMetGluLysArgTyrGlyAsnSerGlyIle-418 420-SerProThrAspSerSerPro-426 432-ProThrAsnGluGluLeu-437 Hydrophilic Regions - Hopp-Woods l-LeuSerSerArgArgArgGlyArgAsnAsnAspArgLysCysGlyIle-16 18-PheAlaGlnArgGlyArgLeuLysHisThrPro-28 34-PheSerAspAspProThrXxxLysLysGlnProGlnThrThrArgArgAsnIleMet-52 70-AlaValIleAspArgLysSerGly-77 84-LeuGlyGluArgLeuThrThr-90 97-PheSerLysAspGlyAsnLysArgGlnValProLeuSerGlyArgAsnCysHis-114 124-GluLeuGluLysHisGluLeuHisAspArgIleGln-135 143-HisGlyGlyGluLysTyrSerGlu-150 157-AlaValMetAspGluLeuAsn-163 204-MetProGluArgAlaTyr-209 215-ArgGluLeuArgLysLysTyrAlaPhe-223 246-LysProLeuGluAspIleArg-252 268-LysAsnGlyLysSerValAspThr-275 290-ArgCysGlyAspIleAspPro-296 311-AlaGlnValAspGluMetLeuAsnLysLysSerGly-322 328-GluLeuSerAsnAspCysArgThrLeuGluIleAlaAlaAspGluGlyHisGluGlyAlaArgLeu-349 381-IleGlyGluAsnSerArgAsnIleArgAlaLysThr-392 403-IleAspThrLysAlaAsnMetGluLysArgTyrGly-414 433-ThrAsnGluGluLeu-437 a604 AMPHI Regions - AMPHI 36-HisArgValValGlnPheAla-42 53-ValGlyGlyIleHisGlyPheAlaThr-61 78-ValArgAlaGlyGlySerPhe-84 95-ArgThrValSerAlaAspPheLeuGluPhePheGlnSerCysGlyIle-110 114-ValValLeuGlnLeuPheAlaArgValAlaGlnValGlyGlyIleGlnGluAsn-131 148-ArgHisIleAsnPheIleAspGlnIleAlaGlyTrpGlu-160 166-ValGlyTrpIleLysLysPheAsp-173 191-PheGlnAsnCysAlaValLeuHisArg-199 Antigenic Index - Jameson-Wolf 11-AlaAlaCysGlyLysValAspGlnArgThrGlyHisGlyGlyGlyGlyArgAsnGlyAsnArgGlyGlyThrH is-35 67-GlyGlyGlyArgAspGluGlyAspPheArgArgValArgAlaGlyGlySerPhe-84 127-GlyIleGlnGluAsnGlyArgAsnAlaArgValAspGluArgGlyPheGln-143 175-TyrPheGlyCysArgGluArgTyrAlaVal-184 201-MetGlyAsnAsnGly-205 211-LeuProAspPheAspCysAlaAsp-218 Hydrophilic Regions - Hopp-Woods 14-GlyLysValAspGlnArgThrGlyHis-22 24-GlyGlyGlyArgAsnGlyAsnArgGlyGlyThrHis-35 68-GlyGlyArgAspGluGlyAspPheArgArgValArgAla-80 127-GlyIleGlnGluAsnGlyArgAsnAlaArgValAspGluArgGlyPhe-142 178-CysArgGluArgTyrAlaVal-184 214-PheAspCysAlaAsp-218 a605 AMPHI Regions - AMPHI 13-ArgGlnIleTrpLysIleAlaAsp-20 38-ThrLeuPheTyrArgPheIleSerGluAsnPheThrAspTyrMetGln-53 107-LysLeuLysGluIlePheThrAlaIle-115 128-IleLysGlyLeuPheAspAspPheAsp-136 141-ArgLeuGlySerThr-145 155-AlaValLeuLysGlyValAlaGluLeu-163 173-11eAspLeuPheGlyAspAlaTyrGluTyrLeuIleSerAsn-186 188-AlaAlaAsnAlaGlyLys-193 204-ValSerLysLeuIleAlaArg-210 217-GluLysValAsnLysIleTyrAspPro-225 240-PheAspGluHisIle-244 291-AspSerLysProPheAspAlaValValSerAsn-301 341-HisAlaLeuAsnTyr-345 355-ValSerPheProGly-359 433-GluHisIleAlaGluIleValLysLeuPheAla-443 452-AlaGlnAsnAlaAlaGlnGlnThr-459 471-SerTyrValGluProGlu-476 478-ThrArgGluIleIleAspIle-484 489-AlaGluIleSerGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAlaGluIle Glu-513 Antigenic Index - Jameson-Wolf 5-IleGlnGlnArgAlaGlnLeu-ll 18-11eAlaAspGluValArgGlyAlaValAspGlyTrpAsp-30 44-IleSerGluAsnPheThrAspTyrMetGlnAlaGlyAspSerSerIleAsp-60 63-AlaMetProAspSer-67 71-ProGluIleLysAspAspAlaValLysVal-80 98-AlaHisGlnAsnGluGluLeuAsnThrLysLeuLysGlu-110 116-GluSerSerAlaSerGlyTyrProSerGluGlnAspIleLysGlyLeuPheAspAspPheAspThrThrSer SerArgLeu-142 146-ValAlaAspLysAsnLysArgLeu-153 164-AspPheGlySerPheGluAspHisHis-172 190-AsnAlaGlyLysSerGlyGlyGluPhePheThr-200 215-GlyGlnGluLysValAsnLysIleTyrAspProAlaCysGlySerGlySer-231 235-GlnAlaLysLysGlnPheAsp-241 253-GluIleAsnHisThrThrTyrAsn-260 280-LeuGlyAspThrLeuThrAsnProLysLeuLysAspSerLysProPheAspAla-297 310-GlySerGlyAspProThrLeuIleAsnAspAspArgPheAlaPro-324 330-ProLysSerLysAlaAsp-335 345-TyrLeuSerGlyArgGlyArgAlaAla-353 362-TyrArgGlyGlyAlaGluGlnLysIleArg-371 403-LeuSerLysHisLysAspAsnThrAsp-411 418-GlyGlyPhePheLysLysGluThrAsnAsnAsnValLeuThrGluGluHisIle-435 442-PheAlaAspLysAlaAspVal-448 458-GlnThrValLysAspAsnGlyTyr-465 473-ValGluProGluAspThrArgGluIleIleAsp-483 490-GluIleSerGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAla-510 Hydrophilic Regions - Hopp-Woods 18-IleAlaAspGluValArgGlyAlaValAsp-27 55-GlyAspSerSerIle-59 71-ProGluIleLysAspAspAlaValLysVal-80 98-AlaHisGlnAsnGluGluLeuAsnThrLysLeuLysGlu-110 122-TyrProSerGluGlnAspIleLysGlyLeuPheAspAspPheAspThrThrSerSerArgLeu-142 146-ValAlaAspLysAsnLysArgLeu-153 167-SerPheGluAspHisHis-172 191-AlaGlyLysSerGlyGly-196 215-GlyGlnGluLysValAsnLysIleTyrAsp-224 235-GlnAlaLysLysGlnPheAsp-241 287-ProLysLeuLysAspSerLysProPhe-295 316-LeulleAsnAspAspArgPheAla-323 330-ProLysSerLysAlaAsp-335 348-GlyArgGlyArgAla-352 364-GlyGlyAlaGluGlnLysIleArg-371 404-SerLysHisLysAspAsnThrAsp-411 419-GlyPhePheLysLysGluThrAsn-426 430-LeuThrGluGluHisIle-435 442-PheAlaAspLysAlaAspVal-448 458-GlnThrValLysAspAsnGly-464 473-ValGluProGluAspThrArgGluIleIleAsp-483 490-GluIleSerGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAla-510 a606 AMPHI Regions - AMPHI 72-LeuLeuAspHisMetThrArgAspGlu-80 90-AlaHisValGlyAsnGlyAsp-96 100-LeuThrLeuIleGlnGlyValValAsnThrPhe-110 116-ArgIleIleAlaAsn-120 139-SerMetValPheGlnIleLeuPheGlyPheLeuAlaSerLeuIleVal-154 171-LysLeuValGlyAlaProLysMetIleSerAlaLeuGlnArg-184 191-AspLeuProGluGluMetAsnAla-198 Antigenic Index - Jameson-Wolf 13-GluValIleAspThrProArgThrGluGluGluAla-24 31-GluAlaGlnAlaArgGlnTrpAsnLeuLysThrProGlu-43 48-HisSerProGluProAsnAla-54 57-ThrGlyAlaSerArgAsnSerSer-64 75-HisMetThrArgAspGluValGluAla-83 92-ValGlyAsnGlyAsp-96 122-IleAlaArgAsnAsnAspGlySerGlnSerGlnGlyThr-134 159-ArgGlnArgGluTyrArgAlaAspAlaGlyAla-169 182-LeuGlnArgLeuLysGlyAsnProValAspLeuProGluGluMetAsn-197 203-GlyAspThrArgAspSerLeuLeuSerThrHisProSerLeuAspAsnArgIleAlaArgLeuLysSer-22 5 Hydrophilic Regions - Hopp-Woods 13-GluValIleAspThrProArgThrGluGluGluAla-24 59-AlaSerArgAsnSer-63 75-HisMetThrArgAspGluValGluAla-83 124-ArgAsnAsnAspGlySerGlnSer-131 159-ArgGlnArgGluTyrArgAlaAspAlaGlyAla-169 183-GlnArgLeuLysGlyAsnPro-189 191-AspLeuProGluGluMetAsn-197 203-GlyAspThrArgAspSerLeu-209 214-ProSerLeuAspAsnArgl1eAlaArgLeuLysSer-225 a607 AMPHI Regions - AMPHI 18-ArgLeuLeuThrAlaLeuAlaLeu-25 70-PheMetGlyIleMetAlaAlaLeuAsnProMetIleAlaGln-83 90-ThrAspGluValGlyGluThr-96 104-GlyLeuPheLeuGlyValPheGlyMetValLeuMetTrpAlaAlaIleThrProPheArgAsnTrpLeuThr LeuSerAspTyrValGluGlyThrMet-136 151-MetValHisArgAlaLeuHisAlaTyrAlaSerSer-162 226-PhePheArgProPheGly-231 244-PheLysGlnIleTrpLysIleGlyAla-252 320-AlaArgTyrIleSerGlyValSerLeu-3 8 337-IleThrValLeuSerLeuVal-343 373-PheGlnProAlaAspPheThrGlnCysIleAlaSerTyrAla-386 424-TyrGlyPheTrpThrAlaLeuIleAla-432 Antigenic Index - Jameson-Wolf 15-LysGluValArgLeu-19 47-GlyAlaGlyLysGluAspLeuAla-54 86-GlyAlaGlyLysThrAspGluValGlyGluThrGlyArgGlnGlyIle-101 121-ProPheArgAsnTrp-125 128-LeuSerAspTyrValGluGlyThr-135 160-AlaSerSerLeuAsnArgProArgLeu-168 234-AlaLysPheGlyLysProAspTrp-241 311-SerLeuGlyArgArgGluPheSerArgAlaArgTyrIleSer-324 353-TyrAsnAsnAspPro-357 388-ArgGlyTyrLysValThrLys-394 447-LeuCysSerArgGluMetValArgSerHisLysAlaVal-459 Hydrophilic Regions - Hopp-Woods 15-LysGluValArgLeu-19 47-GlyAlaGlyLysGluAspLeuAla-54 88-GlyLysThrAspGluValGlyGluThrGlyArg-98 163-LeuAsnArgProArg-167 312-LeuGlyArgArgGluPheSerArg-319 390-TyrLysValThrLys-394 447-LeuCysSerArgGluMetValArgSerHisLysAlaVal-459 a608 AMPHI Regions - AMPHI 66-AlaValGlnLysIleLeuGln-72 93-ValLeuSerLeuLeu-97 103-ArgAlaSerAspGluLeuAlaArgIlePheGlyThrGln-115 124-AspIleGlyHisGlyIleLysGlnIleGlyArgAsnIleAlaGluGlnIleGlyArgPheSerArgGluPro GluSerAla-150 154-AsnGluAlaLeuAlaAspCysLeuAspGluIleSerArgLeuArgAspGlyValGluArgLeuAsnGluArg LeuAspArgLeu-181 Antigenic Index - Jameson-Wolf 13-LeuGlnSerProAspSerArgSerGluLeu-22 39-LeuAlaGlyArgIleThrGluAspGlyLeuLeuSerAlaGlyAsnGlyPheAlaAspThrGluIleThrPheA rgAsnSerAla-66 71-LeuGlnGlyGlyGluProGlyAlaGlyAspIleGlyLeuGluGly-85 98-GlySerLeuArgSerArgAlaSerAspGluLeuAla-109 114-ThrGlnAlaAspIleGlySerArgAlaAlaAsp-124 131-GlnIleGlyArgAsnIleAla-137 139-GlnIleGlyArgPheSerArgGluProGluSerAlaAsnIleGlyAsn-154 156-AlaLeuAlaAspCysLeuAspGluIleSerArgLeuArgAspGlyValGluArgLeuAsnGluArgLeuAsp ArgLeuGluArgAspIleTrp-186 Hydrophilic Regions - Hopp-Woods 15-SerProAspSerArgSerGluLeu-22 39-LeuAlaGlyArgIleThrGluAspGlyLeu-48 56-AlaAspThrGluIleThrPhe-62 74-GlyGluProGlyAlaGly-79 81-IleGlyLeuGluGly-85 100-LeuArgSerArgAlaSerAspGluLeuAla-109 116-AlaAspIleGlySerArgAlaAlaAsp-124 139-GlnIleGlyArgPheSerArgGluProGluSerAlaAsnIleGly-153 156-AlaLeuAlaAspCysLeuAspGluIleSerArgLeuArgAspGlyValGluArgLeuAsnGluArgLeuAsp ArgLeuGluArgAspIleTrp-186 a609 AMPHI Regions - AMPHI 15-ThrLeuAspAlaPheVal-20 30-HisHisIlePheHisGluPheArgValPheValGlyPhePhe-43 52-PheGluGlnAlaValGlu-57 67-IleAspAspPheLeu-71 114-ValAlaValCysThrVal-119 Antigenic Index - Jameson-Wolf 10-AlaLeuAspAspGluThrLeu-16 20-ValGlyAsnGlnArgSerSerAspIleAla-29 69-AspPheLeuAspThrAspPheGlyIle-77 79-SerGlnAlaAspGlyAsnValArg-86 99-GlyThrArgAlaLysArgGlyTyrGlyAsnHisAspLeu-lll 124-ArgGluAlaAspIle-128 Hydrophilic Regions - Hopp-Woods 10-AlaLeuAspAspGluThrLeu-16 23-GlnArgSerSerAspIle-28 79-SerGlnAlaAspGlyAsnVal-85 100-ThrArgAlaLysArgGlyTyrGly-107 124-ArgGluAlaAspIle-128 a610 AMPHI Regions - AMPHI 6-MetGlnPheProTyr-10 14-SerAlaSerArgMetArgArgMetArgArg-23 98-GluArgAlaGlnGluAlaTyr-104 lll-ProSerThrValArgAlaLeuArgGluArg-120 187-IleArgGluAlaLeuGlu-192 208-TyrAlaSerAlaPheTyrGlyProPheArgAsp-218 223-SerGlyAsnLeuGlyLysAlaAsp-230 268-LeuAspValValArgArgValLysAspGlu-277 296-AlaAlaValAlaAsn-300 Antigenic Index - Jameson-Wolf 11-ArgAsnValSerAlaSerArgMetArgArgMetArgArgAspAspPheSerArgArgLeuMetArgGluHisT hrLeuThrAlaAspAsp-40 50-GlySerAlaArgGluGluAspValProSerMetProGlyValLysArgGlnSerLeuAsp-69 75-AlaGluGluAlaValLys-80 94-AlaAsnLysThrGluArgAlaGlnGluAlaTyrAsnProGluGlyLeuVal-110 115-ArgAlaLeuArgGluArgPhePro-122 139-GlyGlnAspGlyLeuThrAspGluAsnGlyTyrValMetAsnAspGluThrVal-156 175-AlaProSerAspMetMetAspGlyArgIleGlyAlaIleArgGluAlaLeuGluAspAlaGlyHis-196 215-ProPheArgAspAlaValGlySerSerGlyAsnLeuGlyLysAlaAspLysLysThrTyrGlnMetAspPro AlaAsnThrAspGluAlaLeuHis-246 250-LeuAspIleGlnGluGlyAlaAsp-257 270-ValValArgArgValLysAspGluPheGlyVal-280 302-TrpLeuAspGlyGlyLysValVal-309 317-LysArgAlaGlyAlaAspGly-323 331-GluAlaAlaLysMetLeuLysArg-338 Hydrophilic Regions - Hopp-Woods 14-SerAlaSerArgMetArgArgMetArgArgAspAspPheSerArgArgLeuMetArgGluHisThrLeuThrA la-38 50-GlySerAlaArgGluGluAspValProSer-59 61-ProGlyValLysArgGlnSerLeuAsp-69 75-AlaGluGluAlaValLys-80 95-AsnLysThrGluArgAlaGlnGluAlaTyrAsn-105 115-ArgAlaLeuArgGluArgPhePro-122 141-AspGlyLeuThrAspGluAsnGly-148 151-MetAsnAspGluThrVal-156 178-AspMetMetAspGlyArgIleGlyAlaIleArgGluAlaLeuGluAspAlaGly-195 216-PheArgAspAlaValGly-221 225-AsnLeuGlyLysAlaAspLysLysThrTyrGln-235 238-ProAlaAsnThrAspGluAlaLeuHis-246 250-LeuAspIleGlnGluGlyAlaAsp-257 270-ValValArgArgValLysAspGluPheGly-279 317-LysArgAlaGlyAla-321 331-GluAlaAlaLysMetLeuLysArg-338 a611 AMPHI Regions - AMPHI 15-CysArgLeuPheGlyLysLeuSerLeu-23 26-ArgLeuLeuLeuGlyLeu-31 48-ArgSerValArgArgValIle-54 63-GlnValValAlaVal-67 104-ValPheIleGluAspPheVal-llO 129-LeuGlyPheLeuGlyAsnValLeuArgThr-138 Antigenic Index - Jameson-Wolf l-MetProSerGluAsnArgMetGlyLysArgGlnLeuAla-13 32-CysArgSerGlyValCysArgGlyArgCys-41 45-PheProSerArgSerValArgArgValIlePheArgArgValArgIle-60 119-AsnProAlaAspPheArgIle-125 142-AlaSerGlnGluAsp-146 Hydrophilic Regions - Hopp-Woods l-MetProSerGluAsnArgMetGlyLysArgGlnLeuAla-13 35-GlyValCysArgGlyArgCys-41 53-ValIlePheArgArgValArgIle-60 121-AlaAspPheArgIle-125 142-AlaSerGlnGluAsp-146 a612 AMPHI Regions - AMPHI 6-AsnIleAlaLysLysLeuAlaGlyVal-14 55-AlaAspLysAlaValGluLysCysAlaGluAsnValLeu-67 81-GlyAsnPheProAsn-85 101-AsnProTyrXxxLysLeuAsnLysSerLysSerProAspIlePheArgArgPhePheXxxGlyHisSer-12 3 Antigenic Index - Jameson-Wolf 7-IleAlaLysLysLeuAlaGlyValAsp-15 17-11eAlaPheAspPheAspGly-23 27-AspPheGlyArgAspAspAlaValArgHisSerGlyVal-39 57-LysAlaValGluLysCysAlaGlu-64 97-GlyHisHisArgAsnProTyrXxxLysLeuAsnLysSerLysSerProAspIlePheArg-116 Hydrophilic Regions - Hopp-Woods 7-IleAlaLysLysLeuAlaGlyValAsp-15 28-PheGlyArgAspAspAlaValArg-35 57-LysAlaValGluLysCysAlaGlu-64 105-LysLeuAsnLysSerLysSerProAspIlePhe-115 a613 AMPHI Regions - AMPHI 7-SerArgArgSerLeu-ll 95-MetProArgMetArgSer-100 103-SerProMetSerProAla-108 115-ArgIlePheCysThrAlaLeuLeuArgLys-124 140-SerSerValMetArgPro-145 168-LeuSerGlyLeuCysArgIle-174 Antigenic Index - Jameson-Wolf l-Me SerArgSerSerArgSerArgArgSerLeuArgArgSerThrProSerArg-18 23-SerSerArgGlnSerAlaArgAla-30 35-PheAlaAspSerGlySerArgGluAsnLeu-44 73-ProLysIleArgAlaAsnSerSerAspAlaArgGluArgArgLeuProSerArgAspSerThrAla-94 96-ProArgMetArgSerProSerSerProMetSerProAlaProGlySerProProTrp-114 130-AlaLysProPheProAlaGluSerLysProSerSerValMetArgProAlaSer-147 161-LysAlaAlaSerSerGluArgLeuSerGlyLeuCysArgIleArgArg-176 178-MetMetGlyArgArgAlaAspIlePheSerAspArgGlyGlyGlu-192 Hydrophilic Regions - Hopp-Woods l-Me SerArgSerSerArgSerArgArgSerLeuArgArgSerThrProSer-17 24-SerArgGlnSerAlaArgAla-30 38-SerGlySerArgGluAsnLeu-44 73-ProLysIleArgAlaAsnSerSerAspAlaArgGluArgArgLeuProSerArgAspSerThrAla-94 96-ProArgMetArgSerProSer-102 133-PheProAlaGluSerLysProSerSerValMetArg-144 161-LysAlaAlaSerSerGluArgLeuSerGly-170 172-CysArgIleArgArg-176 178-MetMetGlyArgArgAlaAspIlePheSerAspArgGlyGlyGlu-192 a614 AMPHI Regions - AMPHI 20-SerGlnPheIleGlnGlnVal-26 65-AsnLeuIleLysThrLeuLeuAsp-72 90-AlaLeuPheTyrSerLeuLeuProValLeu-99 144-ValAlaGlyCysAspGluAlaLysGluGluValGlnGluIleValAspTyrLeuLysAlaProAsnArgTyr GlnSerLeu-170 210-AspPheValGluMetPheVal-216 222-ArgValArgAspMetPheGluGln-229 242-GluIleAspAlaValGlyArg-248 295-ProAlaLeuGlnArgProGlyArgPheAsp-304 333-SerValAspLeuLeuSerLeuAla-340 349-AlaAspLeuAlaAsnLeuValAsn-356 Antigenic Index - Jameson-Wolf 7-LeuAspGlyLysLysGluAspAsnGlyGlnIleGlu-18 26-ValAsnAsnGlyGluValSerGly-33 45-LeuIleLysGlyGluArgThrAspLysSerThrPhe-56 60-AlaProLeuAspAspAsnLeuIle-67 70-LeuLeuAspLysAsnValArgValLysValThrProGluGluLysProSerAla-87 lll-MetGlnThrGlyGlyGlyGlyLysGlyGly-120 123-SerPheGlyLysSerArgAlaArgLeuLeuAspLysAspAlaAsnLys-138 145-AlaGlyCysAspGluAlaLysGluGluValGlnGlu-156 161-LeuLysAlaProAsnArgTyrGlnSerLeuGlyGlyArgValProArgGly-177 182-GlySerProGlyThrGlyLysThrLeuLeu-191 207-SerGlySerAspPhe-211 219-GlyAlaSerArgValArgAspMetPheGluGlnAlaLysLysAsnAla-234 241-AspGluIleAspAlaValGlyArgGlnArgGlyAlaGlyLeuGlyGlyGlyAsnAspGluArgGluGlnThr Leu-265 272-MetAspGlyPheGluSerAsnGln-279 287-ThrAsnArgProAspValLeuAspProAlaLeuGlnArgProGlyArgPheAspArg-305 311-LeuProAspIleArgGlyArgGluGlnIle-320 323-ValHisSerLysLysValProLeuAspLysSerValAsp-335 34l-ArgGlyThrProGlyPheSerGly-348 362-AlaGlyArgArgAsnLysValLysValAspGlnSerAspLeuLysThrProLysThrLysSer-382 Hydrophilic Regions - Hopp-Woods 7-LeuAspGlyLysLysGluAspAsnGlyGln-16 27-AsnAsnGlyGluValSer-32 46-IleLysGlyGluArgThrAspLysSerThr-55 61-ProLeuAspAspAsnLeuIle-67 70-LeuLeuAspLysAsnValArgValLysValThrProGluGluLysProSer-86 125-GlyLysSerArgAlaArgLeuLeuAspLysAspAlaAsnLys-138 145-AlaGlyCysAspGluAlaLysGluGluValGlnGlu-156 162-LysAlaProAsnArg-166 171-GlyGlyArgValProArg-176 221-SerArgValArgAspMetPheGluGlnAlaLysLysAsnAla-234 241-AspGluIleAspAlaValGlyArgGlnArgGlyAlaGly-253 256-GlyGlyAsnAspGluArgGluGlnThr-264 273-AspGlyPheGluSer-277 287-ThrAsnArgProAspValLeuAsp-294 296-AlaLeuGlnArgProGlyArgPheAspArg-305 312-ProAspIleArgGlyArgGluGlnIle-320 324-HisSerLysLysValProLeuAspLysSerValAsp-335 362-AlaGlyArgArgAsnLysValLysValAspGlnSerAspLeuLysThrProLysThrLys-381 a616 AMPHI Regions - AMPHI 6-LysMetValValGlyLeu-ll 13-AsnProGlyLysGluTyrGlu-19 48-PheGlyGluValAlaArgAla-54 77-ValAlaAlaLeuAlaGlnPheTyrLys-85 115-GlyHisAsnGlyLeuLysAspIle-122 161-ProThrAspArgCysArgArgGlnllePro-170 174-ThrArgHisProCysArgGlnMetArgGly-183 201-ThrAlaCysSerArgPheProTyr-208 265-AlaProValGlnAsnLeuProAsnValAla-274 297-GlyGlyIleTyrSerLeuLeuPhe-304 317-PheAspLysAlaAla-321 355-CysPheAlaLeuPheSerGluCysAlaGlnAlaPhe-366 368-AlaThrArgThrGlySerLeuGlyAspValLeuAlaAspMetAlaGlyThrValLeu-386 Antigenic Index - Jameson-Wolf ll-LeuGlyAsnProGlyLysGluTyrGluGlnThrArgHisAsnAlaGlyPhe-27 39-AlaSerPheLysGluGluLysLysPhePhe-48 51-ValAlaArgAlaThrLeuProAspGlyAsp-60 65-LysProThrThrPheMetAsnArgSerGlyGlnAla-76 86-IleLysProGluGlu-90 96-AspGluLeuAspIleProCysGlyArgIleLysPhe-107 109-LeuGlyGlyGlyAsnGlyGlyHisAsnGlyLeuLysAspIleGlnAla-124 127-GlyThrAlaAspTyrTyrArg-133 138-IleGlyHisProGlyAspArgAsnLeu-146 152-LeuAsnLysProSerThrGluXxxProProThrAspArgCysArgArgGlnIleProAlaSerHisThrArg HisProCysArgGlnMetArgGlyAsnProLeuPro-187 190-GlnMetThrArgCysArgLeuLysProPheGlnThrAlaCysSerArgPheProTyrProAsnSerHisAsp ArgThrGlnAla-217 219-TyrProAsnArgIleHisProArgHisArgArgAsnProArgPheProAla-235 238-MetGlnHisArgArgArgThrIleArgArgArgSerGlyThrMetAlaArgHisThrCysArgThrArgArg GlnIlePro-264 266-ProValGlnAsnLeuProAsnValAlaGlyArgGlyGlyGlyMetLysLeuProArgAsnArgPheSer-28 8 306-AlaAlaAspThrAlaProProProPheProHisPheAspLysAlaAla-321 336-AlaPheLysThrGlyLysLeuProIle-344 368-AlaThrArgThrGlySerLeuGly-375 392-ArgAlaAlaAspArgProAsp-398 Hydrophilic Regions - Hopp-Woods 13-AsnProGlyLysGluTyrGluGlnThrArgHis-23 39-AlaSerPheLysGluGluLysLysPhePhe-48 86-IleLysProGluGlu-90 96-AspGluLeuAspIleProCysGlyArgIleLysPhe-107 117-AsnGlyLeuLysAspIleGlnAla-124 140-HisProGlyAspArgAsnLeu-146 155-ProSerThrGluXxxProProThrAspArgCysArgArgGlnIlePro-170 172-SerHisThrArgHisProCysArgGlnMetArgGlyAsnPro-185 190-GlnMetThrArgCysArgLeuLysPro-198 210-AsnSerHisAspArgThrGln-216 223-IleHisProArgHisArgArgAsnProArg-232 238-MetGlnHisArgArgArgThrIleArgArgArgSerGlyThrMet-252 255-HisThrCysArgThrArgArgGlnIle-263 274-AlaGlyArgGlyGlyGly-279 281-LysLeuProArgAsnArgPhe-287 306-AlaAlaAspThrAla-310 316-HisPheAspLysAlaAla-321 336-AlaPheLysThrGlyLys-341 392-ArgAlaAlaAspArgProAsp-398 a619 AMPHI Regions - AMPHI 50-LysLeuAlaAlaLeuLeu-55 66-GlnLeuPheGlnThrLeuThrAsn-73 134-GlnGlyGlyArgAspLeu-139 146-GlyValIlePheGlyIleLeuPheArgSerLeuSerSerLeuLeuSerArg-162 165-AspProGluGluPhe-169 175-AsnMetPheAlaGlyPheAsnThrValHisSer-185 246-AlaValValGlyProValSerPhePheGlyLeuLeuAlaAlaSerLeuAlaAsnHisPheSer-266 303-LeuSerValValValGluPhe-309 Antigenic Index - Jameson-Wolf l-MetProSerGluLysAsnIle-7 ll-AlaGlySerSerArgPro-16 35-AsnValLysGlyAspTrpAsp-41 132-IleLysGlnGlyGlyArgAspLeuPro-140 163-MetIleAspProGluGluPheThr-170 203-TrpArgGluArgTyrArgLeu-209 213-LeuLeuGlyArgAspGlnAla-219 265-PheSerProSerValLysHisSerVal-273 Hydrophilic Regions - Hopp-Woods l-MetProSerGluLysAsnIle-7 134-GlnGlyGlyArgAspLeuPro-140 163-MetIleAspProGluGluPheThr-170 203-TrpArgGluArgTyrArgLeu-209 213-LeuLeuGlyArgAspGlnAla-219 269-ValLysHisSerVal-273 a620 AMPHI Regions - AMPHI 9-ValAlaValSerAlaLeuSerAlaCysArgGlnAla-20 31-IleSerAspArgSerVal-36 67-SerThrIleLysGlnMetPheGlyTyrThrLysLeuProGluGluProLysGlyIleArgValIleTyrValT hrAspMetGlyAsnValThrAspTrpThr-100 139-GlnAlaGluLysPhe-143 Antigenic Index - Jameson-Wolf 15-SerAlaCysArgGlnAlaGluGluGlyProProProLeuProArgGlnIleSerAspArgSerValGlyHis- 38 43-AsnLeuThrGluHisAsnGlyProLysAla-52 57-AsnGlyLysProAspGlnProVal-64 75-TyrThrLysLeuProGluGluProLysGlyIle-85 97-ThrAspTrpThrAsnProAsnAlaAspThrGluTrpMetAspAlaLysLys-113 125-GlyMetGlyAlaGluAspAlaLeuProPheGlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGly GlyLysValValGlyPheAspAspMetProAspThrTyr-161 Hydrophilic Regions - Hopp-Woods 18-ArgGlnAlaGluGluGlyProProProLeu-27 30-GlnIleSerAspArgSerVal-36 46-GluHisAsnGlyProLys-51 58-GlyLysProAspGln-62 77-LysLeuProGluGluProLysGlyIle-85 103-AsnAlaAspThrGluTrpMetAspAlaLysLys-113 127-GlyAlaGluAspAlaLeu-132 135-GlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGlyGlyLys-150 155-AspAspMetProAsp-159 a622 AMPHI Regions - AMPHI 28-LeuProGluAlaValArgAsnLeuAlaArg-37 62-GluGluIleIleArgTrpLeuAlaAsp-70 112-IleLeuGlyGlnIleLysAspAlaValArgValAlaGln-124 131-LysLysLeuAsnAlaLeuPheGlnLys-139 142-SerValAlaLysGluVal-147 169-GluGlnIlePheProAspIleGlyAsp-177 187-GluMetIleGluLeuValAla-193 214-AlaGlnGluLeuCysAspLys-220 232-AspLeuProAlaIleLeuHis-238 288-AspLeuAsnAspAla-292 297-ValAspAspMetValAsnIleValGlnSerGly-307 324-GluLysValAlaGluPheValArgGlnGln-333 345-LeuArgAspGluGlyGluLys-351 354-LysGlnValLeuGluAsnAlaMetLysGlnLeuAlaLys-366 384-LysLeuLeuHisSerProThrGlnThrLeuAsnLysAlaGlyGlu-398 Antigenic Index - Jameson-Wolf 16-SerIleArgGluLysLeuAla-22 30-GluAlaValArgAsnLeuAlaArgSerAsnAlaAla-41 49-ThrCysAsnArgThrGlu-54 57-CysValGlyAspSerGluGluIleIle-65 75-ProIleGluGluIleSerProTyrLeu-83 90-GluThrValArgHis-94 115-GlnIleLysAspAlaValArgValAlaGlnGluGlnGluSerMetGlyLysLysLeu-133 142-SerValAlaLysGluValArgThrAspThrAlaValGlyGluAsnSerVal-158 174-AspIleGlyAspLeuAsn-179 199-LysSerProArgLeu-203 210-ThrLeuAlaArgAlaGlnGluLeuCysAspLysLeuGlyValAsnAlaGlu-226 257-GlyMetValGluArgAlaLeuLysGlnArgGlnSer-268 277-AlaValProArgAspIleGluAlaGluValGlyAspLeuAsnAsp-291 305-GlnSerGlyLysGluAlaArgGlnLysAlaAlaAlaAla-317 321-LeuValSerGluLysValAlaGluPheValArgGlnGlnGlnGlyArgGlnSerVal-339 343-ArgAlaLeuArgAspGluGlyGluLysAlaArgLysGlnValLeu-357 368-AlaThrAlaGluGluValLeuGlu-375 381-LeuThrAsnLysLeuLeuHisSerProThrGlnThrLeuAsnLysAlaGlyGluGluAspLysAspLeuVal -404 Hydrophilic Regions - Hopp-Woods 16-SerIleArgGluLysLeuAla-22 30-GluAlaValArgAsnLeuAlaArgSerAsnAlaAla-41 59-GlyAspSerGluGluIleIle-65 75-ProIleGluGluIleSer-80 90-GluThrValArgHis-94 115-GlnIleLysAspAlaValArgValAlaGlnGluGlnGluSerMetGlyLysLysLeu-133 142-SerValAlaLysGluValArgThrAspThrAlaValGlyGluAsnSerVal-158 210-ThrLeuAlaArgAlaGlnGluLeuCysAsp-219 257-GlyMetValGluArgAlaLeuLysGlnArgGlnSer-268 277-AlaValProArgAspIleGluAlaGluValGlyAspLeuAsn-290 305-GlnSerGlyLysGluAlaArgGlnLysAlaAlaAlaAla-317 321-LeuValSerGluLysValAlaGluPheValArg-331 333-GlnGlnGlyArgGlnSer-338 343-ArgAlaLeuArgAspGluGlyGluLysAlaArgLysGlnValLeu-357 368-AlaThrAlaGluGluValLeuGlu-375 392-ThrLeuAsnLysAlaGlyGluGluAspLysAspLeuVal-404 a624 AMPHI Regions - AMPHI 14-LeuLeuLeuGlyIleIleGlyIlePheLeuPro-24 45-ArgPheHisArgTrpLeuHis-51 58-ProMetValHisAsn-62 92-PheProGlnArgTrpTrpValGlyAla-100 102-SerSerValPheCysSerLeuValAlaIle-lll Antigenic Index - Jameson-Wolf 41-LysAlaSerProArgPheHisArgTrp-49 51-HisArgHisArgTyrPheGlyProMet-59 63-TrpGluGlnAsnGlyAlaValProArgLysAlaLys-74 115-ArgArgProGluSer-119 Hydrophilic Regions - Hopp-Woods 67-GlyAlaValProArgLysAlaLys-74 115-ArgArgProGluSer-119 a625 AMPHI Regions - AMPHI 25-SerGlyArgIleIleSerIleAlaAla-33 64-LysMetProProGluMetValTyrArgAla-73 Antigenic Index - Jameson-Wolf 5-ArgLysMetLysLysMetThrMetCysThrArgArgVal-17 57-ProPheLysSerProGlnThrLysMetProPro-67 73-AlaSerSerSerArgMetLysGly-80 96-AspAlaProLysThrLysLeuAsnGlyMetArgLysSerAsnValGln-lll Hydrophilic Regions - Hopp-Woods 5-ArgLysMetLysLysMetThrMetCysThrArgArgVal-17 60-SerProGlnThrLysMetProPro-67 74-SerSerSerArgMetLysGly-80 96-AspAlaProLysThrLysLeuAsnGlyMetArgLysSerAsnValGln-111 a627 AMPHI Regions - AMPHI 21-LeuGlnAsnLeuVal-25 56-IleAlaGluValGlyLysLeuPheLeuGlyIlePheIleThrIlePheProValLeuSerIleLeuLysAlaG lyGluAlaGlyAlaLeuGlyGlyValValSerLeuValHisAspThrAlaGlyHisProIle-100 109-GlyIleLeuSerAlaPheLeuAspAsnAla-118 141-PheHisSerLeuLeuAlaValSer-148 153-PheMetGlyAlaLeuThrTyrIleGlyAsnAlaProAsnPheMetValLys-169 181-ThrPhePheGlyTyr-185 Antigenic Index - Jameson-Wolf 3-GlyLeuTrpLysProGluHisProGlyPhe-12 41-ThrProLysGlnValArgAlaGlyAsnGluPheAsnPhe-53 94-AspThrAlaGlyHis-98 128-AlaGlyGlyAspAla-132 170-AlaIleAlaGluGlnArgGlyValPro-178 Hydrophilic Regions - Hopp-Woods 5-TrpLysProGluHisProGly-ll 43-LysGlnValArgAlaGlyAsn-49 170-AlaIleAlaGluGlnArgGlyVal-177 a628 AMPHI Regions - AMPHI 10-CysGlyProProAsnSerCysValSerMetLeuAlaAlaPheSerAspGlyThrSerAlaProAlaAla-32 34-HisThrTrpIleLeuArgSer-40 Antigenic Index - Jameson-Wolf 6-LysProAlaGlyCysGlyProProAsnSer-15 23-PheSerAspGlyThrSerAla-29 40-SerValLysArgLeuAsnThrSerLysProArgLeuLysSerSerAla-55 77-MetAlaAsnGlySerAlaSerThr-84 91-GlyArgValArgSerAlaValHisLysProAspTrpIleArgLeuArgArgThrSerSerProLeuLys-113 116-AsnAlaSerGlyAla-120 Hydrophilic Regions - Hopp-Woods 40-SerValLysArgLeuAsnThrSerLysProArgLeuLysSerSerAla-55 91-GlyArgValArgSerAlaValHisLys-99 101-AspTrpIleArgLeuArgArgThrSerSer-110 a629 AMPHI Regions - AMPHI 32-ArgTrpSerAspValPheSer-38 48-1leSerArgLeuProArgThrPhe-55 116-ValAlaAlaLeuIleGlyMetLeuValPhe-125 146-IlePheGlyGlyValValGluAlaValAlaThr-156 167-MetLeuGlyValTrpGlnGlnGlyAsp-175 191-GlyIleLeuAlaLeuPheAla-197 205-ThrIleLeuGlyLeuGlyGlu-211 252-ValValProAsnIleIleSerArgLeuIleGlyAspArgLeuArgGlnSer-268 285-IleIleGlyArgVal-289 300-ThrValPheGlyValLeu-305 Antigenic Index - Jameson-Wolf 38-SerLeuSerAspSerGln-43 50-ArgLeuProArgThr-54 77-AsnArgPheValGluProSerMetAlaGlyAlaGlyGln-89 131-ArgLeuProProThrAla-136 174-GlyAspPheSerGly-178 260-LeuIleGlyAspArgLeuArgGlnSer-268 316-ArgLysProAlaHis-320 Hydrophilic Regions - Hopp-Woods 260-LeuIleGlyAspArgLeuArgGln-267 316-ArgLysProAlaHis-320 a630 AMPHI Regions - AMPHI 9-LeuPheProAlaMetPheTyrGlyMetTyrAsn-19 30-ProAspLeuLeuGlnGlnSerIleAlaAsnAspTrpHisTyrAlaLeu-45 81-GlyGlyPheTrpGluValLeuPheAla-89 135-PheGlyGlyThrGlyLysAsnPhe-142 169-AlaValAspGlyTyrSerGlyAlaThrAlaLeuAlaGlnTrp-182 187-AlaAspGlyLeuLysAsnAlaIle-194 203-AspAlaPheIleGlyLysLeuProGlySerIleGlyGluValSer-217 230-PheAlaArgIleAlaSerTrpArgIleIleAlaGlyValMet-243 247-IleAlaMetSerSerLeuPheAsnPhe-255 289-ValSerAlaSerPheThrAsnValGlyLysTrpTrpTyrGlyAlaLeuIleGlyValMetCysValLeuIle ArgVal-314 327-IleLeuPheAlaAsnLeuPheAlaProIlePheAspTyrPhe-340 Antigenic Index - Jameson-Wolf 91-ValArgLysHisGluIleAsnGlu-98 133-GluValPheGlyGlyThrGlyLysAsnPheMet-143 157-TyrProAlaAsnLeuSerGlyAspAla-165 186-GlyAlaAspGlyLeuLys-191 209-LeuProGlySerIleGly-214 257-GlySerAspThrAsnAla-262 345-AsnlleLysArgArgLysAlaArgSerAsnGly-355 Hydrophilic Regions - Hopp-Woods 91-ValArgLysHisGluIleAsn-97 345-Asnl1eLysArgArgLysAlaArgSerAsnGly-355 a638 AMPHI Regions - AMPHI 17-LeuAlaArgPheValAspAsnVal-24 30-IleValAspIleValGluHis-36 46-AspIleValLysHisPheGluProLeuGlyLys-56 118-ArgAlaGlyArgValPro-123 149-IleGlyArgThrMetGln-154 198-GluArgTyrValArgArgValTyrGlyTyrGlyThrPro-210 212-ProValSerPheAspGlyCysArgThrValGlyArgPro-224 242-SerGlnPheGluArgIleAlaArgProGly-251 Antigenic Index - Jameson-Wolf 13-GlyLysAsnAlaLeu-17 43-AlaAspGlyAspIle-47 52-GluProLeuGlyLysHisGln-58 81-ValAspGlyGluThrGlnIle-87 99-AlaGlyIleGlyLysAsnAlaVal-106 113-ValAlaAspAspLeuArgAlaGlyArgValProAsnGlyAsn-126 135-GlnSerArgValAlaAsp-140 153-MetGlnIleAspAlaAspArgIleIle-161 168-AsnGlnGlyAlaArgGlySerPhe-175 178-IleAsnThrGlyIleHis-183 188-HisThrGlyThrGlyAsnGlyGlnValAlaGluArgTyrValArg-202 213-ValSerPheAspGlyCysArgThrValGlyArgProPheAsnArgAsnArgPheValAsp-232 240-AlaGlySerGlnPheGluArgIleAlaArgProGlyAlaGlyLysCysGly-256 Hydrophilic Regions - Hopp-Woods 43-AlaAspGlyAspIle-47 52-GluProLeuGlyLys-56 81-ValAspGlyGluThrGlnIle-87 113-ValAlaAspAspLeuArgAlaGlyArgValProAsn-124 136-SerArgValAlaAsp-140 153-MetGlnIleAspAlaAspArgIleIle-161 195-GlnValAlaGluArgTyrValArg-202 216-AspGlyCysArgThrValGly-222 243-GlnPheGluArgIleAlaArgProGlyAlaGly-253 a639-l AMPHI Regions - AMPHI 95-TyrLysAsnAsnArg-99 137-LeuLysValPheAspAsnIle-143 157-ValAsnTyrSerAspIleHisAspAsnIleIleAsnLysAla-170 269-AlaProValSerArg-273 290-GlnPheProAlaValLeuProGly-297 322-AspGlyLeuLeuLysLysValGlu-329 Antigenic Index - Jameson-Wolf 13-GluGluThrAlaPro-17 23-HisAsnAsnIleLeuAspAsnSer-30 41-AlaMetValArgGluAsnLysIleValGly-50 52-AlaThrLeuArgValAsnGluArgGlyAsnGly-62 75-GlyAsnAspIleSerLysGlyArgAspGlyIlePheSerAsnThrSerThrHisAsnThrTyrLysAsnAsnA rgPheSerAsp-102 lll-TyrThrAsnAspSerGluIleSerGly-119 121-IleSerValGlyAsnAsn-126 135-GluArgLeuLysVal-139 145-ValGlySerArgAspGlnGlyIle-152 160-SerAspIleHisAspAsnIleIleAsnLysAlaGlyLys-172 179-AlaAsnTyrAspLysLeuSerAlaAsnHis-188 203-GluGlyThrSerLeuHisAspAsnSerPheIleAsnAsnGluSerGlnValLysTyrVal-222 228-AspTrpSerGluGlyGlyHisGlyAsnTyrTrpSerAspAsnSerAla-243 246-LeuAsnGlyAspGlyPheGlyAspSerAlaTyrArgProAsnGlyIleIle-262 297-GlyGlyValValAspSerLysProLeuMetLysProTyrAlaProLysIleGlnThr-315 318-GlnAlaMetLysAspGlyLeuLeuLysLysValGluThrArgGlnLeuGluTrpGlyArgAlaGluAsnGly SerLeuAsn-344 Hydrophilic Regions - Hopp-Woods 41-AlaMetValArgGluAsnLysIleValGly-50 52-AlaThrLeuArgValAsnGluArgGlyAsn-61 77-AspIleSerLysGlyArgAspGlyIle-85 95-TyrLysAsnAsnArgPheSerAsp-102 113-AsnAspSerGluIleSerGly-119 135-GluArgLeuLysVal-139 146-GlySerArgAspGlnGly-151 180-AsnTyrAspLysLeuSer-185 299-ValValAspSerLysProLeuMet-306 318-GlnAlaMetLysAspGlyLeuLeuLysLysValGluThrArgGlnLeuGluTrpGlyArgAlaGluAsnGly Ser-342 a640 AMPHI Regions - AMPHI 6-SerIleLeuLysSerIleGlyIle-13 22-SerIleLysArgMetSer-27 47-LeuProAlaTyrAlaGluArgLeuProAspPheLeuAlaLysIleGlnPro-63 72-ArgTyrSerLysPro-76 109-SerLysProIleAspThrLeuMetAla-117 127-AlaLysLeuValAspHis-132 Antigenic Index - Jameson-Wolf 24-LysArgMetSerAlaPheArgAlaArgIle-33 50-TyrAlaGluArgLeuProAspPheLeuAlaLysIleGlnProSerGluIleValProGlyAlaAspArgTyrS erLysProGluGlyLysProMetVal-82 85-ValTyrLysGlyAspGluGlnLeu-92 101-AlaValAsnThrArgGlyTyrSerSerLysProIleAsp-113 118-LeuAlaLysAspGlyThr-123 128-LysLeuValAspHisHisGlu-134 Hydrophilic Regions - Hopp-Woods 24-LysArgMetSerAlaPheArgAlaArgIle-33 50-TyrAlaGluArgLeuPro-55 68-ProGlyAlaAspArgTyrSerLysProGluGlyLysProMetVal-82 85-ValTyrLysGlyAspGluGlnLeu-92 118-LeuAlaLysAspGlyThr-123 128-LysLeuValAspHisHisGlu-134 a642 AMPHI Regions - AMPHI 6-CysProLeuSerAlaIleSerAlaVal-14 116-IleLysHisIleValArgAlaPhe-123 138-GlyValSerAlaPheLysThrLeuArgAlaGlnGluPheLeuGlnHisLeuArgGlyGlyVal-158 161-PheArgGlyGluGly-165 167-AspAspValArgLeu-171 186-AlaAspValAlaValLysAsnLeuGlyAsnLeuMetAlaAlaProAsp-201 220-ValPheLysGlyValPheHisAsnAlaValArgHisAlaAspGlnLeuGln-236 270-ValAspGlyValThrAspGlyAla-277 296-GlnValAspAspPheGlyGluPheAlaValPhe-306 325-PheArgGlyValAsp-329 378-AlaGluLeuLeuGlnTrpLeuGlnHisGlnArgAlaPheAspAlaGlyThr-394 Antigenic Index - Jameson-Wolf 1-AlaCysArgArglleCysPro-7 22-ValGlnGlnGluGlyCysGly-28 34-LeuTyrGluAspLysGluSerGlyAspAspPheAlaAspLysAspPheLeuGln-51 73-ValAlaGlyAspGlyGlyLysAlaGly-81 103-PheGlyGlyGlyAlaAspLysLeu-110 123-PheLysAsnArgGluGlyAlaAspValAspSerAspIleAla-136 143-LysThrLeuArgAla-147 161-PheArgGlyGluGlyPheAspAspValArgLeu-171 175-MetGlyAspGlyCysAsnGlyArgAsnGlyMet-185 208-AspGluSerAspValValAla-214 230-ArgHisAlaAspGlnLeuGlnAlaAlaAlaAspLysAspValLeuGluArgAlaGlnThrGly-250 259-HisGlyGlyCysArg-263 265-PheGlyIleAspAlaValAspGlyValThrAspGly-276 290-CysPheGlyAspGluGlnGlnValAspAspPheGly-301 309-PheGlyGlyAsnGluGluGluValAlaLeu-318 328-ValAspValAsnGly-332 344-PheSerGlyAsnArgArgAlaGlyGly-352 388-ArgAlaPheAspAlaGlyThrGlnArgAsnGly-398 401-ValMetProArgAsnPro-406 Hydrophilic Regions - Hopp-Woods 1-AlaCysArgArglleCys-6 34-LeuTyrGluAspLysGluSerGlyAspAspPheAlaAspLysAspPheLeu-50 76-AspGlyGlyLysAla-80 106-GlyAlaAspLysLeu-110 123-PheLysAsnArgGluGlyAlaAspValAspSerAspIle-135 143-LysThrLeuArgAla-147 164-GluGlyPheAspAspValArgLeu-171 178-GlyCysAsnGlyArgAsnGlyMet-185 208-AspGluSerAspValValAla-214 230-ArgHisAlaAspGlnLeuGlnAlaAlaAlaAspLysAspValLeuGluArgAlaGlnThr-249 269-AlaValAspGlyValThrAspGly-276 290-CysPheGlyAspGluGlnGlnValAspAspPheGly-301 311-GlyAsnGluGluGluValAlaLeu-318 346-GlyAsnArgArgAlaGly-351 393-GlyThrGlnArgAsnGly-398 a644 AMPHI Regions - AMPHI 25-CysGlyArgArgPheAspArgPro-32 55-MetAspThrAlaAlaPheLeuLysHisIleGluSerAlaPheArgArgIlePheAlaAspGlyIleAspLeuM etArgTyrLeu-82 lll-GlnPheGluIleGlnGluValLeuArgIleAlaGly-122 141-GlnProLeuGlnGluPheGlyAsp-148 181-ArgGluMetGlnSerTyrTyrGluTyrThrAsp-191 202-TyrTrpGlnGlyAsn-206 224-LeuAlaLysValIleAspLeuLeu-231 276-AlaGlyLeuArgAlaPheGlnAsn-283 304-LeuGluAsnLeuGluArgTyrValArgAsn-313 333-GluIleLeuTyrArgTyrValCysHis-341 343-ValSerProValAlaProValAlaHis-351 356-AlaAsnIleValLysThrLeuAla-363 372-GlnMetLeuGlnLys-376 399-PheThrIlePheGluGlyProAsn-406 408-MetLeuTyrAlaGluIleTyrAspGlnPheValArgAla-420 439-AspArgLeuGlnThr-443 456-LeuProGluAspIleArgSerPhe-463 481-GlyLysIleIleAlaArgLeu-487 Antigenic Index - Jameson-Wolf 1-MetProSerGluArgSerAlaAspCysCysPro-ll 16-ValLysPheArgLysSerThrLeuAsnCysGlyArgArgPheAspArgProProIleAsnGlyAsnArgGlnA rgLysProMe IleHisThrGluProSerAlaGlnProSerThrMetAsp-56 64-IleGluSerAlaPhe-68 71-IlePheAlaAspGlyIleAsp-77 82-LeuProGluAspLysTrpLeu-88 99-PheLeuAspLysLysTyrGlyGlyArgLysGlySerGlnPheGluIle-114 132-XxxXxxXxxGluGly-136 145-GluPheGlyAspGluAlaGlnIle-152 159-ValPheLysGlyGluGlyGlyGlyLeu-167 170-ThrGluProGluThrSerGly-176 178-AlaIleAlaArgGluMetGlnSerTyrTyrGluTyrThrAspGlyGlnThr-194 202-TyrTrpGlnGlyAsnSerGlnSerAspPhe-211 216-AlaLysGluArgLysAsnGlyLysLeuAlaLys-226 235-LysThrTyrIleArg-239 241-GluThrLeuAlaSerGluGlyLeuArg-249 254-AlaValAsnArgIleAspAlaGluMet-262 270-LeuSerGlnSerAspAlaAlaGly-277 306-AsnLeuGluArgTyrValArgAsnAspIleArgPheValAspTyrGluArgArgGluIleArgArgArgHis GlnVal-331 381-LysGlyPheGluArgGlyHisThrAlaGlyAsn-391 403-GluGlyProAsnAspMetLeu-409 420-AlaThrAlaGluGluLysGluAlaGlyMetLysLeuAspLysAsnGlnThrLeuLeuAspArgLeuGlnThr AspAlaArgPhe-447 449-AlaValAlaArgAspTyrThrLeuProGluAspIleArgSerPheLeu-464 493-AlaGluHisGluAspThrAla-499 505-AspIleArgLysAspIleLeuAspCysArgTyrCysGly-517 Hydrophilic Regions - Hopp-Woods l-MetProSerGluArgSerAlaAspCys-9 17-LysPheArgLysSerThrLeuAsnCysGlyArgArgPheAspArgProProIleAsnGlyAsnArgGlnArgL ysProMetIle-44 64-IleGluSerAlaPhe-68 82-LeuProGluAspLysTrpLeu-88 100-LeuAspLysLysTyrGlyGlyArgLysGlySerGln-lll 145-GluPheGlyAspGluAlaGlnIle-152 160-PheLysGlyGluGlyGly-165 170-ThrGluProGluThrSerGly-176 178-AlaIleAlaArgGluMetGlnSer-185 216-AlaLysGluArgLysAsnGlyLysLeuAlaLys-226 254-AlaValAsnArgIleAspAlaGluMet-262 271-SerGlnSerAspAlaAlaGly-277 306-AsnLeuGluArgTyrValArgAsnAspIleArgPheValAspTyrGluArgArgGluIleArgArgArgHis GlnVal-331 381-LysGlyPheGluArgGlyHisThr-388 420-AlaThrAlaGluGluLysGluAlaGlyMetLysLeuAspLysAsnGlnThrLeuLeuAspArgLeuGlnThr AspAlaArgPhe-447 458-GluAspIleArgSerPheLeu-464 493-AlaGluHisGluAspThrAla-499 505-AsplleArgLysAspIleLeuAsp-512 a645 AMPHI Regions - AMPHI 21-AsnThrLeuAsnArgCysCysLys-28 87-ArgThrLeuProSerLeuAsnGlyLeuThrLys-97 149-ThrProLysArgCysSerSerSerIle-157 163-PheLeuAsnPheMetSerSerCysThrSerLeu-173 210-SerAlaLysArgSer-214 249-SerValLeuProLysPro-254 Antigenic Index - Jameson-Wolf 18-GluGlnSerAsnThrLeuAsnArgCysCysLysLysSerArgMetThrCysSerSerSerArgSerArgSerC ysProCys-44 47-ProMetArgAlaSerGlySerArgValSerSerArgSerArgMet-61 68-SerLeuCysArgLysAsnThrCysProProArgLeuSerSerArgAsnThrAlaSerArgThrLeuProSer- 91 99-LeuThrAlaArgArgArgLeuGly-106 HO-IleSerGluLysSerArgSerProSerSer-119 137-ThrLeuAlaArgArgArgLeuSerCysSerPheArgThrProLysArgCysSerSer-155 184-SerAlaMetProSer-188 198-LeuLysArgGluArgLeuAla-204 207-ThrGlyLysSerAlaLysArgSerAlaLys-216 221-CysSerThrArgSerValValGlyAla-229 242-AsnAlaAlaArgArgAlaThr-248 250-ValLeuProLysProThrSerProHisThrArgArgSerIle-263 Hydrophilic Regions - Hopp-Woods 19-GlnSerAsnThrLeu-23 25-ArgCysCysLysLysSerArgMetThrCysSerSerSerArgSerArgSerCysPro-43 48-MetArgAlaSerGlySerArgValSerSerArgSerArgMet-61 69-LeuCysArgLysAsnThrCysProProArgLeuSerSerArgAsnThrAlaSerArgThr-88 99-LeuThrAlaArgArgArgLeuGly-106 HO-IleSerGluLysSerArgSerProSer-118 137-ThrLeuAlaArgArgArgLeuSerCys-145 148-ArgThrProLysArgCysSer-154 198-LeuLysArgGluArgLeuAla-204 209-LysSerAlaLysArgSerAlaLys-216 242-AsnAlaAlaArgArgAlaThr-248 254-ProThrSerProHisThrArgArgSerIle-263 a647 AMPHI Regions - AMPHI 38-GlyLysValCysArgCysPheGluGlnVal-47 69-ThrValPheArgGlnIleIleArgIleValAspHisAla-81 Antigenic Index - Jameson-Wolf 26-GlyLeuValLysGluArgAlaArg-33 39-LysValCysArgCysPhe-44 54-GlyThrValGlyGlnThrGluArgGlyAla-63 79-AspHisAlaAspThrGluArgThrAlaAlaHisSerGlyGlyThrArgGly-95 Hydrophilic Regions - Hopp-Woods 26-GlyLeuValLysGluArgAlaArg-33 40-ValCysArgCysPhe-44 56-ValGlyGlnThrGluArgGlyAla-63 79-AspHisAlaAspThrGluArgThrAlaAla-88 a648 AMPHI Regions - AMPHI 7-ArgIleGluArgAlaValArg-13 15-AlaValIleAspValLeuAsnValAsp-23 44-AlaLeuAlaAspIleArgValLeu-51 94-AlaValAspLeuHisAlaValIleLysLeuThrAspThrVal-107 127-GlnGlyValGluGlnGly-132 152-PheLysGluGlyAsn-156 182-AlaArgThrLeuGlyAsnValPheHis-190 194-GlySerGlyValAspGlyIleGlnAlaValValAlaPheAspGlnTyrAla-210 Antigenic Index - Jameson-Wolf l-MetAsnArgArgAsnAlaArgIleGluArgAlaValArg-13 23-AspAlaProGlySerGlyThrLeuLeuHisGlnArgGlyLysGlnValGlySerArgAsnAspAlaLeuAla- 46 65-GlyLysLysArgPheValGlnSerArgAsnLeuValGlyArgLysGlnArgAsn-82 125-MetProGlnGlyValGluGlnGlyCysArg-134 142-ArgThrGlyPheAspCysArgLeuLysHisPheLysGluGlyAsnAla-157 172-SerAlaAspThrSerGlyIleAspAlaAspAlaArgThr-184 191-AsnArgAlaGlySerGlyValAspGly-199 Hydrophilic Regions - Hopp-Woods l-MetAsnArgArgAsnAlaArgIleGluArgAlaValArg-13 33-GlnArgGlyLysGlnValGlyΞerArgAsnAspAlaLeuAla-46 65-GlyLysLysArgPheValGln-71 74-AsnLeuValGlyArgLysGlnArgAsn-82 127-GlnGlyValGluGlnGlyCysArg-134 143-ThrGlyPheAspCysArgLeuLysHisPheLysGluGlyAsnAla-157 172-SerAlaAspThrSerGlyIleAspAlaAspAlaArgThr-184 a649 AMPHI Regions - AMPHI 6-LeuSerAlaIleLeuGlyLeuVal-13 27-ArgAspThrLysHisIleArgLysAlaAsn-36 57-SerGlnGlyAsnVal-61 63-GluLeuArgGluAsnLys-68 71-ArgLysAlaPheArgSerLeu-77 Antigenic Index - Jameson-Wolf 20-GlyThrSerGluProAlaHisArgAspThrLysHisIleArgLysAlaAsnLys-37 40-LeuHisProGluCysArgLysTyrLeuGluArgArgAlaAla-53 56-ArgSerGlnGlyAsnValGlnGluLeuArgGluAsnLysLysAlaArgLysAlaPheArgSerLeuProTyrL ysGluGlnLysThrGlnCys-86 92-AlaPheAspAspPheAspGlySerArgPheArgArg-103 Hydrophilic Regions - Hopp-Woods 20-GlyThrSerGluProAlaHisArgAspThrLysHisIleArgLysAlaAsnLys-37 42-ProGluCysArgLysTyrLeuGluArgArgAlaAla-53 59-GlyAsnValGlnGluLeuArgGluAsnLysLysAlaArgLysAlaPheArg-75 78-ProTyrLysGluGlnLysThrGlnCys-86 92-AlaPheAspAspPheAspGlySerArgPheArgArg-103 a650 AMPHI Regions - AMPHI 15-SerValCysProGly-19 57-LeuTrpSerGluLeuArgGln-63 72-ProGluLeuValArgArgHisGlu-79 89-PheAsnArgValIleAsn-94 137-SerGlyLeuTrpGln-141 173-AsnTyrLeuGlnTyrLeuTyrGlyLeuPheGlyAspTrpPro-186 198-AsnValGlyArgAlaIleAsnArgAlaArg-207 218-LeuArgMetProAsnGluThr-224 269-GluAlaIleAlaArgLeuAlaGlyIleThrGlnSer-280 314-SerAsnTyrLeuAsnAlaAlaProAsp-322 341-IleSerThrAlaThrGlyMet-347 349-IleAlaAspIleLysArgLeuAsnAsnLeu-358 376-LysThrLeuGlnThrAlaSerGlu-383 433-ValArgThrXxxThr-437 Antigenic Index - Jameson-Wolf l-MetSerLysLeuLys-5 24-GlnAsnThrSerSerHis-29 38-LeuAsnSerSerIleLeuAspLeuProProThrLysGlnTyrPhe-52 59-SerGluLeuArgGlnGlyPheArgMetGlyGluValAsnProGluLeuValArgArgHisGluSerLysPheI le-83 92-ValIleAsnArgSerArgProTyr-99 105-AsnGluValLysLysArgAsnMetProAla-114 128-ThrLysAlaLysΞerHisValGlyAlaSerGly-138 145-AlaThrGlyArgHisTyrGlyLeuGluLysThrProValTyrAspGlyArgHisAspIle-164 192-TyrAsnTrpGlyGluGlyAsnValGlyArgAlaIleAsnArgAlaArgAlaGlnGlyLeuGluProThrTyr GluAsnLeuArgMetProAsnGluThrArgAsnTyrVal-228 247-AsnIleSerAspIleAspAsnLysProTyr-256 259-AlaValGluProAspArgProLeuAspAsnGluAlaIleAla-272 294-PhelleProLysSerLysArgLysLeu-302 318-AsnAlaAlaProAspSer-323 332-ProAlaAlaLysThrSerLeuSerAspIleSerThr-343 350-AlaAspI1eLysArgLeuAsnAsnLeuAsnGly-360 370-LeuValAlaLysAsnGlyLysThrLeuGlnThrAlaSer-382 388-IleAspIleAspAsnThrProAsnThrTyrArgSerAsnMetProAlaGlyThr-405 411-AlaArgIleArgProAlaAla-417 428-LeuProGlnLysThrValArgThrXxxThrArgSerProCysProTyrCys-444 446-ThrCysProCysAspSerArgSerAlaThrSerAsnArgLysThrAspArgHisAlaVal-465 Hydrophilic Regions - Hopp-Woods l-MetSerLysLeuLys-5 61-LeuArgGlnGlyPheArgMetGlyGluValAsnProGluLeuValArgArgHisGluSerLysPhe-82 92-ValIleAsnArgSerArgPro-98 105-AsnGluValLysLysArgAsnMetProAla-114 128-ThrLysAlaLysSerHisVal-134 150-TyrGlyLeuGluLysThrProValTyrAspGlyArgHisAspIle-164 202-AlaIleAsnArgAlaArgAlaGlnGlyLeu-211 213-ProThrTyrGluAsnLeuArgMetProAsnGluThrArgAsnTyrVal-228 249-SerAspIleAspAsn-253 260-ValGluProAspArgProLeuAspAsnGluAlaIleAla-272 296-ProLysSerLysArgLysLeu-302 33 -AlaLysThrSerLeu-338 350-AlaAspIleLysArgLeuAsn-356 373-LysAsnGlyLysThrLeuGlnThrAlaSer-382 389-AspIleAspAsnThrProAsnThrTyr-397 411-AlaArgIleArgPro-415 431-LysThrValArgThrXxxThrArgSer-439 447-CysProCysAspSerArgSerAlaThrSerAsnArgLysThrAspArgHisAlaVal-465 a652-l AMPHI Regions - AMPHI 6-AspIlePheAlaArg-10 52-ArgAspGlyAspLys-56 62-LysGlyValLeuLysAlaValGluHisValAsnAsnGlnIleAlaGlnAla-78 130-LeuTyrArgTyrLeuGlyGlyAlaGlyPro-39 149-ValIleAsnGlyGly-153 173-LysSerPheArgGluAlaLeuArgCys-181 184-GluIlePheHisAlaLeuLysLys-191 266-AlaGluPheAlaGluTyrLeuGluGlyLeuValAsn-277 323-AlaGluGlyIleGluLysGlyVal-330 338-ValAsnGlnIleGlyThrLeuSerGluThrLeuLysAlaValAspLeuAlaLys-355 377-AspLeuAlaValAla-381 391-SerLeuSerArgSerAspArgMetAlaLysTyrAsnGlnLeuLeuArgIleGluGluLeuAlaGluAlaAla Asp Tyr-417 Antigenic Index - Jameson-Wolf ll-GluIleLeuAspSerArgGlyAsnProThrValGlu-22 36-AlaValProSerGlyAlaSerThrGlyGlnLysGluAlaLeuGluLeuArgAspGlyAspLysSerArgTyrS erGlyLysGlyValLeuLysAlaValGluHisValAsn-72 83-AspAlaAsnGluGlnSerTyr-89 97-LeuAspGlyThrGluAsnLysGlyAsnLeuGly-107 121-AlaAlaAlaGluAspSerGlyLeuPro-129 135-GlyGlyAlaGlyProMet-140 151-AsnGlyGlyGluHisAlaAsnAsnSerAsn-161 173-LysSerPheArgGluAlaLeuArgCysGlyAla-183 190-LysLysLeuCysAspSerLysGlyPheProThrThrValGlyAspGluGlyGlyPhe-208 211-AsnLeuAsnSerHisLysGluAlaLeu-219 243-CysAlaSerSerGluPheTyrLysAspGlyLysTyrHisLeuGluAlaGluGlyArgSerTyrThrAsn-26 5 283-SerIleGluAspGlyMetAspGluAsnAspTrpGluGly-295 299-LeuThrGluLysLeuGlyGlyLys-306 309-LeuValGlyAspAspLeu-314 318-AsnProLysIleLeuAlaGluGlyIleGluLysGlyVal-330 352-AspLeuAlaLysArgAsnArgTyrAla-360 363-MetSerHisArgSerGlyGluThrGluAspSerThrIle-375 388-LysThrGlySerLeuSerArgSerAspArgMetAl Lys-400 405-LeuArgIleGluGluGluLeuAlaGluAlaAlaAspTyrProSerLys-420 Hydrophilic Regions - Hopp-Woods ll-GluIleLeuAspSerArgGlyAsnProThrValGlu-22 43-ThrGlyGlnLysGluAlaLeuGluLeuArgAspGlyAspLysSerArgTyrSerGly-61 63-GlyValLeuLysAlaValGlu-69 97-LeuAspGlyThrGluAsnLysGlyAsnLeu-106 121-AlaAlaAlaGluAspSerGly-127 153-GlyGluHisAlaAsn-157 173-LysSerPheArgGluAlaLeuArgCysGlyAla-183 190-LysLysLeuCysAspSerLysGly-197 202-ValGlyAspGluGlyGlyPhe-208 213-AsnSerHisLysGluAlaLeu-219 247-GluPheTyrLysAspGlyLysTyrHisLeuGluAlaGluGlyArgSerTyrThr-264 283-SerIleGluAspGlyMetAspGluAsnAspTrpGluGly-295 299-LeuThrGluLysLeuGlyGly-305 321-IleLeuAlaGluGlyIleGluLysGlyVal-330 352-AspLeuAlaLysArgAsnArgTyr-359 364-SerHisArgSerGlyGluThrGluAspSerThrIle-375 391-SerLeuSerArgSerAspArgMetAlaLys-400 405-LeuArgIleGluGluGluLeuAlaGluAlaAlaAspTyrProSer-419 a653 AMPHI Regions - AMPHI 6-MetArgMetProGluValThrLysGlyPheSerGlySer-18 60-ThrMetArgLysProArgLeuThr-67 75-AlaLeuIlePheThrCysPheAla-82 96-ThrAlaLeuAlaAlaIleThrCysIle-104 Hl-LeuGlyLysMetGluGluPheAsn-118 Antigenic Index - Jameson-Wolf 4-GluProMetArgMetProGluValThrLysGlyPheSerGlySer-18 45-GlyCysArgSerThrArgLysThr-52 56-ValArgProGluThrMetArgLysProArgLeuThrAsnSerSerAla-71 86-AsnSerGlyCysAsnAla-91 103-CysIleSerGlyProProCysArgLeuGlyLysMetGluGlu-116 125-SerArgHisLysIleThrProProArgGlyProArgArgVal-138 145-ThrLysSerGlnAsnGlyThrGly-152 154-GlyTyrSerProProAlaThrArgProAla-163 Hydrophilic Regions - Hopp-Woods 4-GluProMetArgMetProGluValThrLys-13 47-ArgSerThrArgLysThr-52 57-ArgProGluThrMetArgLysProArgLeuThrAsn-68 107-ProProCysArgLeuGlyLysMetGluGlu-116 126-ArgHisLysIleThrProProArgGlyProArg-136 158-ProAlaThrArgProAla-163 a656 AMPHI Regions - AMPHI 14-MetAlaArgThrLeuGlyAlaProGlu-22 42-ArgArgProSerThr-46 92-LeuAlaSerLeuAsnLysSerCys-99 Antigenic Index - Jameson-Wolf 6-GlySerThrSerSer-10 19-GlyAlaProGluSerValProAlaGlyLysValAlaAla-31 40-SerPheArgArgProSerThrLeuGlu-48 74-ArgProThrSerLeuArgProLysSerIleAsn-84 94-SerLeuAsnLysSerCysSerLeuAlaArgSerSerAlaGlyValLeuProArgArgArgValProAla-116 120-ThrMetThrSerSerArgSerArgArgThrArgIleSerGlyGluGluProThrMetTrpLysSerProLys Ser-144 Hydrophilic Regions - Hopp-Woods 40-SerPheArgArgProSerThr-46 76-ThrSerLeuArgProLysSer-82 99-CysSerLeuAlaArgSerSer-105 109-LeuProArgArgArgValProAla-116 121-MetThrSerSerArgSerArgArgThrArgIleSerGlyGluGluProThrMet-138 140-LysSerProLysSer-144 a657 AMPHI Regions - AMPHI 9-ProAlaMetLeuGly-13 2O-LeuGlyArgMetPheThr-25 62-ThrAlaLeuGluGluLeuAlaLysCysAlaAla-72 85-MetArgPheLeuAlaLys-90 140-PheLeuProGlyIleLeuLysThr-147 161-LysThrValAspGluLeuLysAla-168 178-CysValLeuGluLysMetValAsp-185 203-GlnThrPheAspProAlaGluAsnIle-211 232-GlnGlnAlaArgGlnMetAlaGlnArgLeuAlaAspGluLeuAsnTyrValGlyValLeu-251 279-HisThrValAspAlaCysAlaAla-286 314-AsnIleLeuGlyAsp-318 Antigenic Index - Jameson-Wolf l-MetLysAsnIleSerLeu-6 16-GlyGlyGlyGlnLeuGlyArg-22 37-ValLeuAspProAsnProAsnAlaPro-45 57-ProPheAspAsnGlnThrAlaLeuGluGluLeuAlaLys-69 75-ThrGluPheGluAsnValAsnAlaAspAla-84 91-HisThrAsnValSerProSerGlyAsp-99 106-AsnArgIleGlnGluLysAlaTrpIle-114 128-CysLysAlaGluAspIleThrGluGluSerIle-138 150-LeuGlyTyrAspGlyLysGlyGlnIleArgValLysThrValAspGluLeuLysAlaAlaPheAlaGluHis ArgGlyValAspCysValLeu-180 182-LysMetValAspLeuArgGlyGluIle-190 196-ArgLeuAsnAsnAspAsnValGlnThrPheAspProAlaGluAsnIleHisGluAsnGly-215 230-IleGlnGlnGlnAlaArgGlnMetAla-238 269-IleAlaProArgProHisAsnSerGlyHisHis-279 288-GlnPheGlnGlnGlnVal-293 300-ProProAlaAspThrLysLeuLeuSer-308 319-ValTrpGlnGluAspGlyGlyGluProAspTrp-329 331-ProLeuGlnSerArgProAspAlaHis-339 344-GlyLysLysThrAlaHisLysGlyArgLysMetGly-355 360-LeuSerThrAspSerAspThrAlaPheGlnGluAlaLysLysLeuHis-375 Hydrophilic Regions - Hopp-Woods 62-ThrAlaLeuGluGluLeuAlaLys-69 75-ThrGluPheGluAsnValAsn-81 128-CysLysAlaGluAspIleThrGluGluSerIle-138 152-TyrAspGlyLysGlyGlnIleArgValLysThrValAspGluLeuLysAlaAlaPheAlaGluHisArgGly ValAspCysValLeu-180 182-LysMetValAspLeuArgGlyGluIle-190 197-LeuAsnAsnAspAsn-201 206-AspProAlaGluAsnIleHis-212 230-IleGlnGlnGlnAlaArgGlnMetAla-238 269-IleAlaProArgProHisAsn-275 301-ProAlaAspThrLysLeu-306 320-TrpGlnGluAspGlyGlyGluProAsp-328 334-SerArgProAspAla-338 344-GlyLysLysThrAlaHisLysGlyArgLysMetGly-355 362-ThrAspSerAspThrAlaPheGlnGluAlaLysLysLeuHis-375 a658 AMPHI Regions - AMPHI 28-ArgGlnTyrAlaAspValValGlnPheIleGlyGlnThrLeuArgHisLeuSerArgLeuLeuLeuAsn-50 57-TrpAspAspGlyVal-61 68-ValAsnValPheGlyArgIleGluSer-76 94-GlnValHisHisPhePheGlnAsnAlaIleHisAla-105 128-IleAlaGlnCysSerGlyPheGlnAspAlaGlyGln-139 143-AlaPhePheSerAspValPheGly-150 Antigenic Index - Jameson-Wolf 6-ValArgThrArgArgAspPheValAspAspGlnPheMetArgValAlaAspAsnLysHisPhe-26 55-SerGlyTrpAspAspGlyValGlyGluAspThrVal-66 72-GlyArgIleGluSer-76 84-ThrAlaTyrAspAsnGlyAsn-90 108-PheGlyLysArgGlyPhe-113 131-CysSerGlyPheGlnAspAlaGlyGlnLys-140 155-LeuIleArgArgGlyLeuGln-161 174-ValLeuArgAspGlyAsnAla-180 189-MetPheGlyGluLysThrHisArgIleGly-198 202-PheGluLeuGlyArgAsnSerArgThr-210 216-GlnSerGlyLeuValValLysArgArgThrGln-226 230-GlyLysPheArgCysArgArg IleArgVal-239 251-PheGlySerAsnSerLysHisSerAla-259 Hydrophilic Regions - Hopp-Woods 6-ValArgThrArgArgAspPheValAsp-14 16-GlnPheMetArgValAlaAspAsnLysHisPhe-26 56-GlyTrpAspAspGlyValGlyGluAspThrVal-66 72-GlyArgIleGluSer-76 135-GlnAspAlaGlyGln-139 174-ValLeuArgAspGlyAsnAla-180 190-PheGlyGluLysThrHisArgIleGly-198 203-GluLeuGlyArgAsnSerArg-209 220-ValValLysArgArgThrGln-226 230-GlyLysPheArgCysArgArgIleArgVal-239 253-SerAsnSerLysHisSerAla-259 a661 AMPHI Regions - AMPHI 19-GlyIleThrAspLysProPheArgArgLeuCysArgAspPheGlyAlaGly-35 37-AlaValCysGluMetLeu-42 75-AspProGlnGlnMetAlaAspAlaAla-83 122-AlaAlaIleLeuGluAlaValValLys-130 152-ProValIleAlaLysIleAlaGlu-159 222-TyrAspArgAlaArgArg-227 235-ProArgPheGluThrLeuArgArgThrArgCys-245 248-AlaCysLeuGluPheGlyArgMetTyrArgHisTyrPheGluPro-262 267-AlaArgValLeuArgArgHis-273 Antigenic Index - Jameson-Wolf 20-11eThrAspLysProPheArgArgLeuCysArgAspPheGlyAlaGly-35 42-LeuThrSerAspProThrLeuArgAsnThrArgLysThrLeuHisArgSerAspPheAlaAspGluGlyGly- 65 72-AlaGlySerAspProGlnGlnMetAlaAspAlaAlaArg-84 97-AsnMetGlyCysProAlaLysLysValCys-106 143-GlyTrpHisAspAspHisGlnAsnLeu-151 157-IleAlaGluAspCysGly-162 168-XxxProArgThrHisAla-173 176-AsnValGlnArgArgSerGlyLeuArgProAspCysArgAsnGlnMetProSerGluHisProGlyLeuGly GlnArgArgHisTyrLeuAlaAlaLysSerProSerArgProGlnThrAsnArgArgArgArgHisTyrAspArgA laArgArgAlaArgGln-230 235-ProArgPheGluThrLeuArgArgThrArgCysPhe-246 256-TyrArgHisTyrPheGluProHisProSerHisAlaArgValLeuArgArgHisArgArgCysAlaHisArg ThrGlnThrHisArgLeuValHisArgArgAsnAlaArgArgArgThrAspThrSer-298 Hydrophilic Regions - Hopp-Woods 20-11eThrAspLysProPheArgArgLeuCysArgAspPhe-32 46-ProThrLeuArgAsnThrArgLysThrLeuHisArgSerAspPheAlaAspGluGlyGly-65 73-GlySerAspProGlnGlnMetAlaAspAlaAlaArg-84 100-CysProAlaLysLysValCys-106 157-IleAlaGluAspCysGly-162 176-AsnValGlnArgArgSerGlyLeuArgProAspCysArgAsnGlnMetProSerGluHisProGlyLeuGly GlnArgArgHisTyrLeu-205 208-LysSerProSerArgProGlnThrAsnArgArgArgArgHisTyrAspArgAlaArgArgAlaArgGln-23 0 238-GluThrLeuArgArgThrArgCys-245 268-ArgValLeuArgArgHisArgArgCysAlaHisArgThrGlnThr-282 285-LeuValHisArgArgAsnAlaArgArgArgThrAspThrSer-298 a663 AMPHI Regions - AMPHI 19-ProPheAlaLeuLeuHisLysLeuAlaAspLeuThrGlyLeuLeuAlaTyr-35 66-LysGlnHisPheLysHisMetAlaLysLeu-75 87-AlaGlyArgLeuLysSerLeuValArg-95 168-GluGlyLeuArgAlaLeuValLysGlnPheArgLys-179 209-ThrIleThrGlyLeuSerArgIleAlaAlaLeuAlaAsn-221 243-ProAlaTrpGluSer-247 258-GlnArgMetAsnArgPheIleGluGluArgValArgGluHis-271 Antigenic Index - Jameson-Wolf 38-ValLysProArgArgArgIleGlyGlu-46 56-TrpAspGlyLysLysArgLysThrValLeu-65 87-AlaGlyArgLeuLysSer-92 94-ValArgTyrArgAsnLysHisTyrLeuAsp-103 105-AlaLeuAlaAlaGlyGluLys-lll 139-TyrSerHisGlnLysAsnLysIleLeuAsp-148 150-GlnIleLeuLysGlyArgAsnArgTyr-158 166-ArgThrGluGlyLeuArgAlaLeu-173 175-LysGlnPheArgLysSerSerAla-182 188-ProAspGlnAspPheGlyArgAsnAspSerVal-198 229-ProValArgGluAlaAspAsnThr-236 243-ProAlaTrpGluSerPheProSerGluAspAlaGlnAlaAspAlaGlnArgMetAsnArgPheIleGluGlu ArgValArgGluHisProGlu-273 280-LysArgPheLysThrArgProGluGlySerProAspPheTyr-293 Hydrophilic Regions - Hopp-Woods 39-LysProArgArgArgIleGlyGlu-46 56-TrpAspGlyLysLysArgLysThrValLeu-65 88-GlyArgLeuLysSer-92 94-ValArgTyrArgAsn-98 105-AlaLeuAlaAlaGlyGluLys-lll 142-GlnLysAsnLysIleLeuAsp-148 150-Glnl1eLeuLysGlyArgAsnArgTyr-158 166-ArgThrGluGlyLeuArgAlaLeu-173 176-GlnPheArgLysSerSer-181 190-GlnAspPheGlyArgAsnAspSerVal-198 229-ProValArgGluAlaAspAsn-235 248-PheProSerGluAspAlaGlnAlaAspAlaGlnArgMetAsnArgPheIleGluGluArgValArgGluHis ProGlu-273 280-LysArgPheLysThrArgProGluGlySerPro-290 a664 AMPHI Regions - AMPHI 28-AlaHisArgMetCys-32 47-AlaAspValPheAspThrAlaHisGlyAlaAlaGly-58 88-AlaArgProValValGluIle-94 Antigenic Index - Jameson-Wolf 25-SerGlyGlyAlaHisArgMetCysGlyArg-34 48-AspValPheAspThrAlaHisGly-55 73-PheLeuGlnArgLysLeuGluPro-80 108-IleGlyGlyGlyThrAlaValGlyLysAspGluLeuGlyValLysAspValGln-125 137-AlaHisGlyAspAspHisGluAsn-144 164-AlaIleProArgGlnSerArgProTrp-172 175-ProLeuArgTrpCysLysThrArgPhe-183 Hydrophilic Regions - Hopp-Woods 74-LeuGlnArgLysLeuGluPro-80 113-AlaValGlyLysAspGluLeuGlyValLysAspValGln-125 137-AlaHisGlyAspAspHisGluAsn-144 166-ProArgGlnSerArg-170 a665-l AMPHI Regions - AMPHI 6-HisTyrLeuLysAspTyrGln-12 105-LeuTyrAlaSerAla-109 111-AsnLeuPheThrGlnCysGluProGluGlyPheArgLysIleThr-125 132-AspValMetSerLysPheThrThrThr-140 167-ArgHisTrpValLysTrpGluAspProPhe-176 225-SerLeuLysAsnAlaMetLys-231 286-GlyIleGluSerValVal-291 294-GluTyrPheHisAsnTrpThr-300 307-ArgAspTrpPheGlnLeuSerLeu-314 329-AspArgAlaSerArgAlaValArgArgIleGluAsnIleArgLeuLeuArgGln-346 360-ValArgProAlaArgTyrGluGluMetAsnAsnPheTyrThr-373 380-GlyAlaGluValValArgMetTyrHisThrLeu-390 396-PheGlnLysGlyMetLys-401 520-ThrGluAlaValValProSerLeuLeuArgGlyPheSerAlaPro-534 555-AspAlaPheThrArgTrpGluAlaAlaGln-564 575-LeuAlaAlaLeuSerAspGlyValGluLeuProLysHisGluLysLeuLeuAlaAlaValGlu-595 603 -LeuAspAsnAlaPheLysAlaLeu-610 622-AspGlyAlaGluAsnIleAspProLeu-630 648-LeuProLysTrpHisGluLeuAsnArg-656 G674-lyTrpArgThrLeuArgAsnValCysArgAla-684 696-ThrValAlaGluLysTyrAlaGluMetAlaGlnAsnMet-708 712-TrpGlyIleLeuSer-716 728-ArgLeuLeuAlaGlnPheAlaAspLysPheSer-738 758-AspThrLeuGlnGlnValGlnThrAla-766 782-SerLeuIleGlySerPheSerArgAsnVal-791 822-ArgLeuValGlnAlaPheAsnLeuCysAsnLysLeu-833 Antigenic Index - Jameson-Wolf 8-LeuLysAspTyrGlnThrProAlaTyr-16 26-AspIleAsnGluPro-30 34-ValLysSerArgLeuThrValGluProLysArgValGlyGlu-47 49-LeuValLeuAspGlySerAla-55 79-AlaAspValProSerGluArgPheThrVal-88 90-ValGluThrGluIleLeuProAlaGluAsnLysSerLeu-102 114-ThrGlnCysGluProGluGlyPheArgLys-123 128-IleAspArgProAspValMetSer-135 142-ValAlaAspLysLysArgTyrPro-149 154-AsnGlyAsnLysIleAspGlyGlyGluTyrSerAspGlyArgHisTrpValLysTrpGluAspProPheAla LysProSer-180 191-AlaValThrGluAspTyr-196 200-MetSerGlyArgAsnValLysIle-207 211-ThrThrGluAlaAspLysProLysVal-219 230-MetLysTrpAspGluThrArgPhe-237 255-AsnMetGlyAlaMetGluAsnLysGlyLeu-264 275-AspSerArgThrAlaThrAspThrAspPheGluGlyIleGlu-288 295-TyrPheHisAsnTrpThrGlyAsnArgValThrCysArgAspTrp-309 313-SerLeuLysGluGly-317 322-ArgAspGlnGluPheSerGlyAspArgAlaSerArgAlaValArgArgIleGluAsn-340 347-HisGlnPheProGluAspAlaGlyProThrAlaHisProValArgProAlaArgTyrGluGluMetAsn-36 9 376-ValTyrGluLysGlyAlaGluVal-383 394-GluGlyPheGlnLysGlyMet-400 404-PheGlnArgHisAspGlyGlnAlaValThrCysAspAspPheArg-418 437-SerGlnAlaGlyThrPro-442 446-AlaGlnGlyArgLeuLysAsnAsnVal-454 459-IleLysGlnThrValProProThrProAspMetAlaAspLysGlnPro-474 485-AsnCysAsnGlyGluAlaVal-491 494-AspTyrGlnGlyLysArgAlaThrGlu-502 509-GluAlaGluGlnThrPhe-514 537-LeuAsnTyrProTyrSerAspAspAspLeu-546 552-HisAspSerAspAla-556 578-LeuSerAspGlyValGluLeuProLysHisGluLysLeu-590 594-ValGluLysValIleSerAspAspLeuLeu-603 614-ValProSerGluAlaGluLeuTrpAspGlyAlaGluAsnIleAspProLeuArg-631 633-HisGlnAlaArgGluAlaLeu-639 652-HisGluLeuAsnArgGlnAlaAlaLysGlnGluAsnGlnSerTyrGluTyrSerProGluAlaAlaGly-67 4 677-ThrLeuArgAsnValCys-682 689-AlaAspProAlaHis-693 696-ThrValAlaGluLysTyrAlaGlu-703 719-AsnGlyAsnGluSerAspThrArgAsnArgLeu-729 733-PheAlaAspLysPheSerAspAspAlaLeuVal-743 752-GlySerSerArgArgSerAspThrLeuGln-761 768-GlnHisProLysPheSerLeuGluAsnProAsnLysAlaArgSer-782 785-GlySerPheSerArgAsnValPro-792 795-HisAlaGluAspGlySerGlyTyrArgPheIleAla-806 808-LysValIleGluIleAspArgPheAsnProGlnVal-819 831-AsnLysLeuGluProHisArgLysAsnLeuVal-841 844-AlaLeuGlnArgIleArgAlaGlnGluGlyLeuSerLysAspValGlyGluIleVal-862 Hydrophilic Regions - Hopp-Woods 34-ValLysSerArgLeuThrValGluProLysArgValGlyGlu-47 81-ValProSerGluArgPheThrVal-88 90-ValGluThrGluIleLeuProAlaGluAsnLysSer-101 116-CysGluProGluGlyPheArg-122 129-AspArgProAspValMetSer-135 142-Va1AlaAspLysLysArgTyr-148 154-AsnGlyAsnLysIleAspGlyGlyGluTyrSerAspGlyArgHis-168 170-ValLysTrpGluAspProPheAla-177 201-SerGlyArgAsnValLys-206 213-GluAlaAspLysProLysVal-219 230-MetLysTrpAspGluThrArgPhe-237 258-AlaMetGluAsnLysGly-263 275-AspSerArgThrAlaThrAspThrAspPheGluGlyIleGlu-288 313-SerLeuLysGluGly-317 322-ArgAspGlnGluPheSerGlyAspArgAlaSerArgAlaValArgArgIleGluAsn-340 348-GlnPheProGluAspAlaGlyPro-355 361-ArgProAlaArgTyrGluGluMetAsn-369 376-ValTyrGluLysGlyAlaGluVal-383 394-GluGlyPheGlnLysGlyMet-400 406-ArgHisAspGlyGln-410 413 -ThrCysAspAspPheArg-418 446-AlaGlnGlyArgLeuLysAsnAsnVal-454 467-ProAspMetAlaAspLysGlnPro-474 495-TyrGlnGlyLysArgAlaThrGlu-502 541-TyrSerAspAspAspLeu-546 552-HisAspSerAspAla-556 580-AspGlyValGluLeuProLysHisGluLysLeu-590 594-ValGluLysValIleSer-599 616-SerGluAlaGluLeu-620 622-AspGlyAlaGluAsnIleAspPro-629 633-HisGlnAlaArgGluAlaLeu-639 652-HisGluLeuAsnArgGlnAlaAlaLysGlnGluAsnGlnSer-665 689-AlaAspProAlaHis-693 696-ThrValAlaGluLysTyrAlaGlu-703 719-AsnGlyAsnGluSerAspThrArgAsnArgLeu-729 733-PheAlaAspLysPheSerAsp-739 753-SerSerArgArgSerAspThr-759 776-AsnProAsnLysAlaArgSer-782 795-HisAlaGluAspGlySerGly-801 808-LysValIleGluIleAspArgPheAsn-816 831-AsnLysLeuGluProHisArgLysAsnLeuVal-841 844-AlaLeuGlnArgIleArgAlaGlnGluGlyLeuSerLysAspValGlyGluIleVal-862 a666 AMPHI Regions - AMPHI 89-GlyTyrAspIleLeuLysGlnGlyGlySer-98 162-LeuLysPheMetGluAlaVal-168 Antigenic Index - Jameson-Wolf 5-AsnHisGlnSerAsnSerGlyGluGlyValLeu-15 40-AsnGlnGlyLysValAsnThr-46 54-AlaAspAlaHisThrProGluHisAlaThr-63 65-LeuThrGluGlnLysGln-70 92-IleLeuLysGlnGlyGlySerAlaAla-100 114-GluProGlnSerSerGlyLeuGlyGly-122 130-AspAsnThrAlaLysThr-135 137-ThrThrPheAspGlyArgGluThrAlaPro-146 154-PheLeuAspLysAspGlyGlnPro-161 Hydrophilic Regions - Hopp-Woods 8-SerAsnSerGlyGlu-12 40-AsnGlnGlyLysValAsnThr-46 55-AspAlaHisThrProGluHis-61 65-LeuThrGluGlnLysGln-70 96-GlyGlySerAlaAla-100 139-PheAspGlyArgGluThrAlaPro-146 154-PheLeuAspLysAspGlyGlnPro-161 a667 AMPHI Regions - AMPHI 49-IleAlaAspPheLeuGlnProAlaArgValGluArgLeuProHisLeuAlaAla-66 74-LysThrAlaGlnPhe-78 115-IleAlaAlaValAlaGluIle-121 128-IleAlaArgGlyValAspAlaValGlnArg-137 152-ThrAspGlnLeuArgArgMetPhePheAsnGlnLeuGluLysPheGlyAspAsnHis-170 174-ValIleHisLeuAlaAspCysThrAsp-182 201-LysMetMetLeuHisLysIleProThrArgLeu-211 Antigenic Index - Jameson-Wolf ll-IleValSerAspProLeuAsp-17 27-SerAlaAlaAspGlnThrGluThrGln-35 56-AlaArgValGluArgLeuPro-62 71-LeuAlaArgLysThrAlaGln-77 84-ArgHisIleArgProArgLeuValLysArgGluGlnIle-96 130-ArgGlyValAspAlaValGln-136 139-ValMetGlnAsnArgGlnValGlu-146 151-ProThrAspGlnLeuArg-156 163-LeuGluLysPheGlyAsp-168 179-AspCysThrAspMet-183 188-ProProThrHisAlaAlaArgAsnArgHisAsnLeu-199 207-IleProThrArgLeu-211 226-GlyGlnArgGlyArgGlnValIleGlnArgThrAspThrLeu-239 247-IleGluSerGlnAsnArgGlyHisAspSer-256 Hydrophilic Regions - Hopp-Woods ll-IleValSerAspProLeu-16 27-SerAlaAlaAspGlnThrGluThrGln-35 56-AlaArgValGluArgLeuPro-62 71-LeuAlaArgLysThrAlaGln-77 84-ArgHisIleArgProArgLeuValLysArgGluGlnIle-96 130-ArgGlyValAspAlaValGln-136 164-GluLysPheGlyAsp-168 191-HisAlaAlaArgAsnArgHisAsnLeu-199 227-GlnArgGlyArgGlnValIleGlnArgThrAspThr-238 249-SerGlnAsnArgGlyHisAsp-255 a669 AMPHI Regions - AMPHI 24-LysLeuHisArgAlaPhe-29 59-GlnIlePheArgHisValGlnSer-66 79-LysProProAsnThrAla-84 Antigenic Index - Jameson-Wolf l-MetArgArgIleIleLysLysHisGlnProValAsn-12 33-GlyArgLysArgProHisHisHisAspArgSerLeuArgArgGlnHisGlyIle-50 64-ValGlnSerSerAsnArgGlnAsnGlyArgGlnProValCysThrLysProProAsnThrAlaSer-85 100-AlaAspIleLysArgIleLeu-106 Hydrophilic Regions - Hopp-Woods 1-MetArgArgIleIleLysLysHisGlnPro-lO 33-GlyArgLysArgProHisHisHisAspArgSerLeuArgArgGlnHisGly-49 65-GlnSerSerAsnArgGlnAsnGlyArgGlnProValCysThrLysProProAsn-82 100-AlaAspIleLysArgIleLeu-106 a670 AMPHI Regions - AMPHI 10-ArgSerCysPheGly-14 16-ValLysAsnAlaSerGlyValSer-23 34-IleThrArgSerAla-38 77-ValGlySerSerAsnAsnIle-83 126-PheSerAlaCysSer-130 Antigenic Index - Jameson-Wolf 4-CysArgAsnCysLeuAlaArgSerCys-12 18-AsnAlaSerGlyValSerSerSerArgIleCysProLeuSer-31 33-LysIleThrArgSerAlaThrSerArgAlaAsnProIle-45 65-AsnThrSerProThrIleSerGlySerSerAlaGluValGlySerSerAsnAsnIleThrArgGlySerIleA laLysProArgAlaIleAla-95 98-CysCysTrpProProGluSerTrpGluGlyLysAla-109 114-AlaSerProThrArgSerLysSerSer-122 145-AsnThrValArgCysGly-150 Hydrophilic Regions - Hopp-Woods 33-LysIleThrArgSerAlaThrSerArgAlaAsn-43 73-SerSerAlaGluValGlySer-79 87-SerIleAlaLysProArgAlaIleAla-95 116-ProThrArgSerLysSer-121 a671 AMPHI Regions - AMPHI 96-ThrProArgIleAla-100 119-ArgLeuPheIleArgTyr-124 Antigenic Index - Jameson-Wolf 11-PheAsnAlaProAsnThrProProLysMetArgLeuAlaLysProLysProThrAlaGluThrAlaProValS erSerGluArg-38 45-GlnAlaMetThrAsnArgGluMetAsnAspArgAlaAsnAlaAsnArgArgGlyTrpAsnAspAlaLysAlaM etSerAlaLysGlyAlaAlaLysSerLeuAlaLysLysLysAlaThrThr-85 98-ArgIleAlaAspSerThrMet-104 110-AlaGluThrArgArgSerAlaThrGlyArgLeu-120 125-LeuThrGlyAspThr-129 Hydrophilic Regions - Hopp-Woods 16-ThrProProLysMetArgLeuAlaLysProLysProThrAlaGlu-30 32-AlaProValSerSerGluArg-38 47-MetThrAsnArgGluMetAsnAspArgAlaAsnAlaAsnArgArgGlyTrpAsnAspAlaLysAlaMetSerA laLysGlyAlaAlaLysSerLeuAlaLysLysLysAlaThrThr-85 110-AlaGluThrArgArgSerAlaThr-117 a672 AMPHI Regions - AMPHI 38-ArgAlaValAspIleIleLysAlaGlnLys-47 50-AlaAlaLeuProProPheValSerValVal-59 67-AlaGlnAsnIleArgArgIleLeuAlaGluValPro-78 91-AlaPheCysArgGlnPheHisArgProTyr-100 105-ArgValGlnThrAlaSerAspIleArgAsnAlaAlaAspArgPhe-119 131-HisProSerGluTyrGly-136 165-AsnValAspGluAlaIle-170 173 -ThrGlyAlaGluAla-177 Antigenic Index - Jameson-Wolf l-MetArgLysIleArgThrLysIleCysGlyIleThrThrProGluAspAlaLeu-18 34-ProGlnSerProArgAlaValAspIleIleLysAlaGlnLys-47 65-GluSerAlaGlnAsnIleArgArgIleLeuAla-75 84-PheHisGlyAspGluAspAspAlaPhe-92 107-GlnThrAlaSerAspIleArgAsnAlaAlaAspArgPheProAspAla-122 130-TyrHisProSerGluTyrGlyGlyThrGlyHisArgPheAsp-143 149-GluTyrSerGlyLysPro-154 159-GlyGlyLeuThrProGluAsnValAspGluAlaIleArg-171 176-GluAlaValAspValSerGlyGlyValGluAlaSerLysGlyLysLysAspProAlaLys-195 202-ThrAlaAsnArgLeuSerArg-208 Hydrophilic Regions - Hopp-Woods l-MetArgLysIleArgThrLysIle-8 13-ThrProGluAspAlaLeu-18 36-SerProArgAlaValAsp-41 43-IleLysAlaGlnLys-47 66-SerAlaGlnAsnl1eArgArglleLeuAla-75 85-HisGlyAspGluAspAspAlaPhe-92 110-SerAsplleArgAsnAlaAlaAspArgPheProAsp-121 164-GluAsnValAspGluAlaIleArg-171 184-ValGluAlaSerLysGlyLysLysAspProAlaLys-195 204-AsnArgLeuSerArg-208 a673 AMPHI Regions - AMPHI 84-LeuAsnAspArgLeuAsnGlnAsnValThrGluAlaLeuGlyGlyValAspVal-101 110-ArgPheThrAspAla-114 117-ValValLeuLysGlnLeuProLys-124 172-ArgIleAlaAsnLeuLeuGluLeuIleLysProTyrLeu-184 212-LysLeuPheArgTyrLeuGlyGluGlu-220 261-GlyGluArgLeuLysLysIleSerThr-269 275-MetGluLysLeuPhe-279 285-LeuLysValTrpValLysValLys-292 Antigenic Index - Jameson-Wolf 7-LeuAlaGlyGluArgAlaAlaAspGlyTyrArg-17 24-ValGlyArgProAsnValGlyLysSerThr-33 44-SerIleThrSerLysLysAlaGlnThrThrArgAsnArgValThr-58 61-TyrThrAspAspThrAla-66 73-ThrProGlyPheGlnThrAspHisArgAsnAlaLeuAsnAspArgLeuAsnGlnAsnValThrGlu-94 110-ArgPheThrAspAlaAspArgValVal-118 121-GlnLeuProLysHisThr-126 134-LysIleAspLysAspLysAlaLysAspArgTyrAla-145 153-ValArgAlaGluPhe-157 180-IleLysProTyrLeuProGluSerVal-188 190-MetTyrProGluAspMetValThrAspLysSerAlaArg-202 208-IleValArgGluLysLeuPhe-214 217-LeuGlyGluGluLeuPro-222 227-ValGluValGluGlnPheGluGluGluAspGlyLeuAsn-239 247-ValAspLysGluSerGlnLys-253 258-GlyLysGlyGlyGluArgLeuLysLysIleSerThrGluAlaArgLeuAspMetGluLysLeuPheAsp-28 0 291-ValLysSerGlyTrpAlaAspAspIleArgPheLeuArg-303 Hydrophilic Regions - Hopp-Woods 7-LeuAlaGlyGluArgAlaAlaAspGlyTyrArg-17 45-IleThrSerLysLysAlaGlnThrThrArgAsnArgVal-57 61-TyrThrAspAspThrAla-66 78-ThrAspHisArgAsnAlaLeuAsnAspArgLeuAsn-89 110-ArgPheThrAspAlaAspArgVa1Va1-118 134-LysIleAspLysAspLysAlaLysAspArgTyrAla-145 153-ValArgAlaGluPhe-157 194-AspMetValThrAspLysSerAlaArg-202 208-IleValArgGluLysLeuPhe-214 217-LeuGlyGluGluLeuPro-222 227-ValGluValGluGlnPheGluGluGluAspGlyLeuAsn-239 247-ValAspLysGluSerGlnLys-253 259-LysGlyGlyGluArgLeuLysLysIleSerThrGluAlaArgLeuAspMetGluLysLeuPheAsp-280 293-SerGlyTrpAlaAspAspIleArgPheLeuArg-303 a674 AMPHI Regions - AMPHI 16-ValTyrGlnSerLeuIle-21 24-ThrAlaAlaProGluIleAlaLysAsnIleArgGluMetProAspPheAlaLys-41 58-AlaAlaGluTyrIleArgGlnIleArgPro-67 86-ThrAlaCysHisGluLeuSerAlaMetProGluThr-97 107-IleGluValThrLysThrPheGlyGlyThrAspGlyHisLysPheValAsnGlyIleLeuAspLysLeuAla -130 Antigenic Index - Jameson-Wolf l-MetLysThrAlaArgArgArgSerArgGluLeuAla-12 28-GluIleAlaLysAsnIleArgGluMetProAspPheAlaLysAlaAspGluGluLeuPhe-47 54-ThrGlnThrAsnAla-58 63-ArgGlnIleArgProLeuLeuAspArgAspGluLysAspLeuAsnProIleGluArg-81 93-AlaMetProGluThrProTyr-99 105-GluAlaIleGluValThrLysThrPheGlyGlyThrAspGlyHisLysPhe-121 129-LeuAlaAlaGlnIleArgProAspGluProLysArgArg-141 Hydrophilic Regions - Hopp-Woods l-MetLysThrAlaArgArgArgSerArgGluLeuAla-12 28-GluIleAlaLysAsnIleArgGluMetProAspPheAlaLysAlaAspGluGluLeuPhe-47 63-ArgGlnIleArgProLeuLeuAspArgAspGluLysAspLeuAsnProIleGluArg-81 105-GluAlaIleGluVal-109 133-IleArgProAspGluProLysArgArg-141 a675 AMPHI Regions - AMPHI 21-ArgPheThrAsnGluIleGlySerGluMetLeuLysValCysCysArgThrLeuGlnGluLeuGly-42 74-AlaLeuIleAlaIle-78 123-GlnAlaIleGluArgIleGluGluLysAlaSerAsp-134 141-GluCysAlaAsnLeuValAsnLeuLeuLeuGlu-151 Antigenic Index - Jameson-Wolf 6-ProAsnLeuAspGlyLysHisLeuArg-14 26-IleGlySerGluMetLeu-31 42-GlyValAlaAspGluAsnIle-48 68-SerSerGluLysPheAsp-73 82IleArgGlyGluThrTyr-87 92-ValSerAsnGluSerGlyAlaGlyVal-100 118-ThrGluAsnAspAlaGlnAlaIleGluArgIleGluGluLysAlaSerAspAlaAlaLysValAlaVal-14 0 152-GluGlnPheGluAspGluGlu-158 Hydrophilic Regions - Hopp-Woods 8-LeuAspGlyLysHisLeuArg-14 26-IleGlySerGluMetLeu-31 42-GlyValAlaAspGluAsnIle-48 68-SerSerGluLysPheAsp-73 82-IleArgGlyGluThrTyr-87 92-ValSerAsnGluSerGlyAlaGly-99 118-ThrGluAsnAspAlaGlnAlaIleGluArgIleGluGluLysAlaSerAspAlaAlaLysValAlaVal-14 0 152-GluGlnPheGluAspGluGlu-158 a677 AMPHI Regions - AMPHI 20-AlaArgLeuCysArgPheArgArg-27 45-LeuThrProPheArgArgValAsnHisPheValAlaPheThrArgPheAsnGln-62 78-IleAspPheIleAspAlaAsp-84 86-PheAspGlyLeuLeuAla-91 105-HisLeuValGlyArgPhe-llO 154-CysArgProValAspAspLeuAspAsp-162 165-AlaPhePheIleAsnGlnLeuIleLysLeuValPheGlnCys-178 Antigenic Index - Jameson-Wolf 23-CysArgPheArgArgHisSerArgSerValAsp-33 35-AspValPheAspArgLysAspPheAsn-43 59-ArgPheAsnGlnThrThrSerGlnArgArgAsnProArgAsnPheVal-74 81-IleAspAlaAspAspPheAspGly-88 96-GlnGlnThrAspGlyArgAlaGluLysHisLeu-106 114-GlyIleAsnAspAspGlyGlyPhe-121 124-LeuGlyGlnGluThrAspAlaAlaVal-132 155-ArgProValAspAspLeuAspAspPheGly-164 180-ProSerGlyGlyArgAsn-185 Hydrophilic Regions - Hopp-Woods 23-CysArgPheArgArgHisSerArgSerValAsp-33 35-AspValPheAspArgLysAspPhe-42 64-ThrSerGlnArgArgAsnProArg-71 81-IleAspAlaAspAspPheAsp-87 96-GlnGlnThrAspGlyArgAlaGluLysHisLeu-106 115-IleAsnAspAspGlyGly-120 125-GlyGlnGluThrAspAlaAlaVal-132 155-ArgProValAspAspLeuAspAsp-162 a678 AMPHI Regions - AMPHI 10-LeuValSerAlaIleIle-15 24-MetArgGlyValIle-28 47-PheAlaAlaProPhe-51 79-LeuIleGlnLysIleLeuArgSerLeuLeuThrGlyAla-91 102-ArgIleLeuGlyGlyValPheGlyAlaLeuLysGlyIleLeu-115 130-ProAspThrGluGlu-134 Antigenic Index - Jameson-Wolf 125-SerLysThrAspLeuProAspThrGluGluTrpArgGlnSerTyrThr-140 154-HisSerGlyGlyThrAlaGluThrProGluAspAsp-165 Hydrophilic Regions - Hopp-Woods 125-SerLysThrAspLeuProAspThrGluGluTrpArgGln-137 157-GlyThrAlaGluThrProGluAspAsp-165 a681 AMPHI Regions - AMPHI 12-PheSerGluGluAlaLysPheIleSerAlaMet-22 102-LeuProValGlyAsp-106 122-ArgLeuGlyGluGlnCys-127 137-IleGlyGluAlaAspAspAlaGluValValArgValValGlyValPheValGly-154 202-LysCysValHisCysGly-207 210-XxxGlyGlyLysLeuAlaAspPheThrThrIle-220 234-CysAlaProPheAlaAlaLeuArgCysPheCysIlePheGlyValTrpLysArgIleArgAlaValPheCys GlyArg-259 Antigenic Index - Jameson-Wolf ll-AsnPheSerGluGluAlaLysPhe-18 39-AlaThrProAsnSerTrpArgValArgGlnGln-49 59-LeuValLysArgAlaCys-64 67-ProMetArgArgCysLeuProSerArgLeu-76 89-GlyGlyPheGlyMetProSerGluGlySerVal-99 103-ProValGlyAspGlyLeuGlu-109 120-AlaPheArgLeuGlyGluGlnCysGlyGlyPhe-130 136-AspIleGlyGluAlaAspAspAlaGluVal-145 157-AlaAlaGluGluThrPro-162 167-PheLysAsnGlyGly-171 173-AlaValGluGluAlaAspGly-179 185-AspGlyValGlyGlyAspAlaAlaValGluCysArgGlyLysCysLeuCys-201 207-GlyAsnThrXxxGlyGlyLysLeuAlaAsp-216 224-SerAlaAspGlyGlyGly-229 256-PheCysGlyArgArg-260 Hydrophilic Regions - Hopp-Woods ll-AsnPheSerGluGluAlaLysPhe-18 44-TrpArgValArgGln-48 59-LeuValLysArgAlaCys-64 67-ProMetArgArgCysLeuPro-73 95-SerGluGlySerVal-99 120-AlaPheArgLeuGlyGluGln-126 136-AspIleGlyGluAlaAspAspAlaGluVal-145 157-AlaAlaGluGluThrPro-162 173-AlaValGluGluAlaAspGly-179 191-AlaAlaValGluCysArgGlyLysCysLeu-200 210-XxxGlyGlyLysLeuAlaAsp-216 256-PheCysGlyArgArg-260 a682 AMPHI Regions - AMPHI 33-ArgLeuArgLysCysGlyArgIleLeuSerGlyIleCysGluProPhe-48 Antigenic Index - Jameson-Wolf 9-SerTyrGlyLysTrpArgLysAsnTrpAspIle-19 30-SerSerThrArgLeuArgLysCysGlyArg-39 95-ArgPheProThrAspArgProIleLeu-103 112-IleSerProArgThrGlyPheArgTyrProThrArgSerLeuProLysSerLysLysAlaTyrGly-133 Hydrophilic Regions - Hopp-Woods 12-LysTrpArgLysAsnTrpAsp-18 32-ThrArgLeuArgLysCysGlyArg-39 97-ProThrAspArgProIleLeu-103 124-SerLeuProLysSerLysLysAlaTyrGly-133 a683 AMPHI Regions - AMPHI 26-ThrProAspLysSerAlaArgTrpGluAsnIleGlyThrIleSerAsn-41 101-SerSerLeuGlnLeuPhe-106 124-ArgProMetSerIleLeuSerGly-131 Antigenic Index - Jameson-Wolf 24-CysSerThrProAspLysSerAlaArgTrpGluAsn-35 37-GlyThrIleSerAsnGly-42 48-11eAsnLysAspSerValArgLysAsnGlyAsn-58 63-XxxAspLysLysValValThrAsnLeuLysGlnGluArgPheAla-77 93-CysAsnAsnLysThrTyrArgLeu-100 106-PheAspThrLysAsnThrGluIleSerThr-115 119-ThrAlaSerSerLeuArgPro-125 131-GlyThrLeuThrGluLysGlnTyrGlu-139 141-ValCysGlyLysLysLeu-146 Hydrophilic Regions - Hopp-Woods 25-SerThrProAspLysSerAlaArgTrpGluAsn-35 48-IleAsnLysAspSerValArgLysAsnGly-57 63-XxxAspLysLysValValThr-69 71-LeuLysGlnGluArgPheAla-77 107-AspThrLysAsnThrGluIleSer-114 133-LeuThrGluLysGlnTyrGlu-139 141-ValCysGlyLysLysLeu-146 a684 AMPHI Regions - AMPHI 13-AlaAlaCysGlyThrValGln-19 47-LeuAlaGluProLeu-51 73-TrpAlaAspThrLeuAspAspMetLeuGluAlaAlaLeuSerAsnAlaPheAsnArgLeuAspSerThr-95 110-TrpThrValTyrIleAspAlaPheGlnGlySerTyr-121 154-AlaMetThrAlaAlaLeuGluGlnGlyLeuLysGlnAlaAlaGlnGlnMetVal-171 Antigenic Index - Jameson-Wolf 26-LeuProAspSerArgTyrIleArgProAlaThrGlnGlyGlyGluThrAlaValGluValArgLeuAlaGluP roLeuLysArgGlyGlyLeu-56 60-ThrAspProTyrArgLeuAsnThrAlaGln-69 76-ThrLeuAspAspMetLeuGlu-82 9O-AsnArgLeuAspSerThrArg-96 101-AlaSerArgSerGlySerThrGluLys-109 117-PheGlnGlySerTyrThrGlyLysThrLeu-126 133-LeuProAspGlyThrAsnArgProPheHisIleGluThrGluGlnGlnGlyAspGlyTyrAla-153 161-GlnGlyLeuLysGlnAlaAla-167 Hydrophilic Regions - Hopp-Woods 27-ProAspSerArgTyrIleArg-33 35-AlaThrGlnGlyGlyGluThrAlaValGluValArgLeuAlaGluProLeuLysArgGlyGly-55 76-ThrLeuAspAspMetLeuGlu-82 9O-AsnArgLeuAspSer-94 102-SerArgSerGlySerThrGluLys-109 141-PheHisIleGluThrGluGlnGlnGlyAsp-150 161-GlnGlyLeuLysGlnAlaAla-167 a685 AMPHI Regions - AMPHI 7-AsnPheAlaPheCysGlyValVal-14 44-CysAlaValLeuLeu-48 94-TrpAlaAlaLeuAspThrLeuThrGluLeu-103 137-TyrGluAlaLeuHisArgTyr-143 154-GlyAlaGluAlaTyrGluGlnLeuAlaLysAsn-164 182-GluLysGlnMetGluThrLeuAlaArgIlePheGlyLysGlu-195 206-AspAlaLeuPheAla-210 296-AlaValGluValLeuAspAsnAlaLeuVal-305 336-AlaAlaGluGlnLeuLysGluAlaPhe-344 Antigenic Index - Jameson-Wolf 20-LeuAsnAsnLysHisSerTyrSerTyrAlaLysGluProHisThrValLysProArgPhe-39 52-SerProGluProAlaAlaGluLysThrValSer-62 74-ProThrAlaArgGlyAspAlaValValProLysAsnProGluArgValAla-90 122-AlaPheAspLysAlaAla-127 133-PheGluProAspTyrGluAlaLeuHisArgTyrAsn-144 151-GlyGlyProGlyAlaGluAlaTyrGluGlnLeuAlaLysAsnAlaThr-166 170-LeuThrValAspAsnGlyAsnIleArgThrSerGlyGluLysGlnMetGluThrLeu-188 192-PheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnIle-205 211-GlnThrArgGluAlaAlaLysGlyLysGlyArgGlyLeu-223 227-ValThrGlyAsnLysValSerAlaPheGlyThrGlnSerArgLeu-241 247-GlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluGlyHisGlyGln-265 271-TyrIleLysGluLysAsnProAspTrpIle-280 285-ArgThrAlaAlaIleGlyGlnGluGlyProAla-295 307-GlyThrAsnAlaTrpLysArgLysGln-315 328-GlyGlySerArgGlnLeu-333 338-GluGlnLeuLysGluAlaPheGluLysAlaGluPro-349 351-AlaAlaGlyLysGlu-355 Hydrophilic Regions - Hopp-Woods 28-TyrAlaLysGluProHisThrValLys-36 52-SerProGluProAlaAlaGluLysThrValSer-62 75-ThrAlaArgGlyAspAlaVa1Va1-82 84-LysAsnProGluArgValAla-90 122-AlaPheAspLysAlaAla-127 135-ProAspTyrGluAla-139 156-GluAlaTyrGluGlnLeuAlaLys-163 175-GlyAsnIleArgThrSerGlyGluLysGlnMetGluThrLeu-188 192-PheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnIle-205 211-GlnThrArgGluAlaAlaLysGlyLysGlyArgGly-222 253-ProValAspGluSerLeuArgAsnGluGlyHisGly-264 271-TyrIleLysGluLysAsnPro-277 290-GlyGlnGluGlyProAla-295 309-AsnAlaTrpLysArgLysGln-315 338-GluGlnLeuLysGluAlaPheGluLysAlaGluPro-349 351-AlaAlaGlyLysGlu-355 a686 AMPHI Regions - AMPHI 10-AspValPheAspAspIleCysSerAlaValGluSerPheGlyGlyIleAlaArgSerValGlnLeu-31 50-ThrThrGlyIleValGluThrValAspLysProLeu-61 70-ValGluAlaAspIle-74 86-IleProArgAlaPheGlySerGlyIleAlaAlaAlaLeu-98 Antigenic Index - Jameson-Wolf l-TerTerAsnPheSerCysArgAlaAspAspValPheAsp-13 46-LeuArgGlnHisThrThrGlyIle-53 55-GluThrValAspLysProLeuSerGlyAla-64 70-ValGluAlaAspIle-74 115-AspAlaValLysAlaGluSerValAsnGlyThrThrGly-127 Hydrophilic Regions - Hopp-Woods 6-CysArgAlaAspAspValPheAsp-13 55-GluThrValAspLysProLeuSer-62 70-ValGluAlaAspIle-74 115-AspAlaValLysAlaGluSerValAsn-123 a687 AMPHI Regions - AMPHI H-AlaAlaLeuPheAlaLeu-16 64-LysValGluValLeuGluPhePheGlyTyrPheCysPro-76 78-CysAlaHisLeuGluProValLeuSerLysHisAlaLysSerPhe-92 112-LeuAlaArgLeuAlaAlaAla-118 135-PheAspAlaMetVal-139 148-ProGluValLeuLysLysTrpLeu-155 176-GlnAlaArgAlaAspLysMetGlnGluLeuThrGluThrPhe-189 Antigenic Index - Jameson-Wolf l-MetLysSerLysHis-5 19-CysAspSerLysValGlnThrSerValProAlaAspSerAlaPro-33 43-GlyLeuValGluGlyGlnAsnTyr-50 56-ProIleProGlnGlnGlnAlaGlyLysValGluVal-67 87-LysHisAlaLysSerPheLysAspAspMetTyrLeu-98 122-AlaAlaAlaAspSerLysAspValAlaAsn-131 141-GlnLysIleLysLeuGlnGluProGluValLeuLys-152 159-ThrAlaPheAspGlyLysLysVal-166 171-GluSerProGluSerGlnAlaArgAlaAspLysMetGlnGluLeuThrGlu-187 189-PheGlnIleAspGlyThrPro-195 199-ValGlyGlyLysTyrLysValGluPheAlaAsp-209 211-GluSerGlyMetAsnThr-216 220-LeuAlaAspLysValArgGluGluGlnLysAlaAlaHis-232 Hydrophilic Regions - Hopp-Woods l-MetLysSerLysHis-5 19-CysAspSerLysValGlnThr-25 27-ValProAlaAspSerAlaPro-33 61-GlnAlaGlyLysValGluVal-67 87-LysHisAlaLysSerPheLysAspAspMetTyrLeu-98 122-AlaAlaAlaAspSerLysAspValAla-130 141-GlnLysIleLysLeuGlnGluProGluValLeuLys-152 159-ThrAlaPheAspGlyLysLysVal-166 171-GluSerProGluSerGlnAlaArgAlaAspLysMetGlnGluLeuThrGlu-187 201-GlyLysTyrLysValGluPheAlaAsp-209 220-LeuAlaAspLysValArgGluGluGlnLysAlaAlaHis-232 a688 AMPHI Regions - AMPHI 23-LeuSerAlaLeuLeuGlyLeu-29 120-GlyAsnAlaLeuGlnAsnAlaAla-127 Antigenic Index - Jameson-Wolf 4-TyrProSerArgPheAlaGln-10 13-IleSerValAsnLys-17 47-IleIleGlnGlyAsnGluLeuGluProArgAla-57 61-LeuArgProGlyMetThrLysAspGln-69 82-AlaPheHisThrAspArgTrpAspTyr-90 93-AsnThrSerArgAsnGlyIleIleLysAspArgSerAsn-105 116-ValArgThrGluGlyAsnAla-122 125-AsnAlaAlaGluAlaLeuArgValLysGlnAsnAlaAspLysGln-139 Hydrophilic Regions - Hopp-Woods 51-AsnGluLeuGluProArgAla-57 64-GlyMetThrLysAspGln-69 98-Gly11el1eLysAspArgSerAsn-105 116-ValArgThrGluGlyAsnAla-122 125-AsnAlaAlaGluAlaLeuArgValLysGlnAsnAlaAspLysGln-139 a689 AMPHI Regions - AMPHI 55-TyrProGluMetSerGluLysLeuMet-63 65-ValLeuMetAlaMetLeuValThrLeu-73 82-LeuProAlaIleProGluMetAlaGln-90 lll-AlaPheGlyGlnValValGlyGly-118 123-IleLysGlyArgLys-127 154-LeuAsnLeuArgValValGlnAlaPheGlyAlaGly-165 188-PheAlaLeuIleGlyIleIleLeu-195 203-ProMetValGlyAlaLeuLeuGlnGlyLeuGlyGlyTrpGlnAlaIlePheVal-220 230-LeuGlyLeuValGlnTyrPhe-236 245-LysIleGlyArgAspVal-250 257-ArgPheLysArgValLeu-262 277-SerPheGlySerMetPheAla-283 314-MetMetPhePheAsnArgIleThr-321 344-AlaAlaAsnLeuSerGlnLeuAlaAlaValLeuPhe-355 400-ValLeuGlyValPheGlnSerLeuIleGly-409 Antigenic Index - Jameson-Wolf 36-PheArgArgArgAlaVal-41 45-IleGlyArgGluPheMetProSer-52 57-GluMetSerGluLysLeu-62 95-AspValHisArgIleGluGln-101 119-SerValSerAspIleLysGlyArgLysProVal-129 174-MetValArgAspTyrTyrSerGlyArgLysAlaAla-185 238-ProLysProAlaValGlyGlyLysIleGlyArgAspValPhe-251 257-ArgPheLysArgValLeuLysThrArgAla-266 325-LeuLysThrGlyValHis-330 390-PheLysGluGluGlyGlySer-396 448-ArgAlaTrpLysGluAsnGlyGlnSerGluTyrLeu-459 Hydrophilic Regions - Hopp-Woods 36-PheArgArgArgAlaVal-41 45-IleGlyArgGluPheMet-50 57-GluMetSerGluLysLeu-62 95-AspValHisArgIleGluGln-101 119-SerValSerAspIleLysGlyArgLysProVal-129 178-TyrTyrSerGlyArgLysAlaAla-185 245-LysIleGlyArgAspVal-250 257-ArgPheLysArgValLeuLysThrArgAla-266 390-PheLysGluGluGlyGlySer-396 448-ArgAlaTrpLysGluAsnGlyGln-455 a690 AMPHI Regions - AMPHI 36-AlaSerSerThrAlaSerAla-42 57-SerAlaProAspAsnValLysGlnAlaGlu-66 68-ValProProSerAsnCysThrAspLeuHisProAlaThrGlyIleAspAspLeuMetGlnGlnIleAlaGluH isIle-93 116-GlyTyrAspAsnIleGlnArgLeu-123 151-ArgThrIleSerArgGlnAlaGlnAspAla-160 189-ProLysArgThrArgTyrPhe-195 213-GlyAsnPheGlnTyrIleGlyGlnLeuProGlyTyrLeuLys-226 Antigenic Index - Jameson-Wolf l-MetLysAsnLysThrSer-6 21-SerProSerLysGluAspLysThrLysGluAsnGlyAla-33 43-AlaSerSerSerAlaProGlnThrAspLeu-52 57-SerAlaProAspAsnValLysGlnAlaGluSerValProProSerAsnCysThrAspLeuHisProAlaThrG lyIleAspAspLeuMet-86 91-GluHisIleAspSerAspCys-97 104-HisGluLeuGluThrArgPhe-llO 112-LeuProGlyGlyGlyTyrAspAsnIleGln-121 126-ProAspIleArgProGluAspProAspTyrHisGln-137 144-GluAspLeuArgTyrGlyLysArgThrIleSerArgGlnAlaGln-158 160-AlaLeuMetGluGlnGluArgArgLeuArgGlu-170 177-GlnGlySerGlnGluThrArgGlyGlnGlyGluGluProLysArgThrArgTyr-194 198-SerAlaThrProAlaTyrSerSerArgHisAsnAsnGlyLeuGlyGlyAsn-214 228-HisGlyGluMetLeuGluAsnGlnSerLeu-237 239-ArgLeuSerAsnArgGluArgAsnProAspLysProPheLeu-252 255-HisPheAspGluAsnGlyLysIleThr-263 267-ValTyrGluLysAsnIleTyrPheAsnProAsnLeuGlyArgArg-281 Hydrophilic Regions - Hopp-Woods 1-MetLysAsnLysThr-5 21-SerProSerLysGluAspLysThrLysGluAsnGlyAla-33 46-SerAlaProGlnThrAspLeu-52 57-SerAlaProAspAsnValLysGlnAlaGluSerValPro-69 81-GlyIleAspAspLeuMet-86 91-GluHisIleAspSer-95 104-HisGluLeuGluThr-108 128-IleArgProGluAspProAspTyrHis-136 144-GluAspLeuArgTyrGlyLysArgThrIleSerArgGlnAlaGln-158 160-AlaLeuMetGluGlnGluArgArgLeuArgGlu-170 178-GlySerGlnGluThrArgGlyGlnGlyGluGluProLysArgThrArgTyr-194 203-TyrSerSerArgHisAsnAsn-209 228-HisGlyGluMetLeuGlu-233 240-LeuSerAsnArgGluArgAsnProAspLysProPhe-251 255-HisPheAspGluAsnGlyLysIleThr-263 a691 AMPHI Regions - AMPHI ll-LysProAlaAlaSer-15 55-HisAsnGluLeuArgLysIleArgAla-63 108-ArgTyrLeuSerGly-112 Antigenic Index - Jameson-Wolf 7-CysArgPheAlaLys-ll 36-LeuAsnAspPheGlnProAsnCysAspIleArgArgLeuGlyLeuThrGlnGlyGlnHisAsnGluLeuArgL ysIleArgAla-63 67-MetAlaGlyAspArgAlaArgLeuLysValMetHis-78 80-GluHisSerArgArgArgSerVal-87 91-IleSerSerAspValPheAsnArgAsnGluAlaArgAspTyrValGluSerArgTyrLeuSerGlyMetAspP heAlaValAspGluLeuGluIle-122 131-ThrProGlnGlnGlnGln-136 140-SerSerCysLeuLys-144 Hydrophilic Regions - Hopp-Woods 43-CysAspIleArgArgLeuGly-49 54-GlnHisAsnGluLeuArgLysIleArgAla-63 67-MetAlaGlyAspArgAlaArgLeuLysValMetHis-78 80-GluHisSerArgArgArgSerVal-87 95-ValPheAsnArgAsnGluAlaArgAspTyrValGlu-106 115-PheAlaValAspGluLeuGluIle-122 a692 AMPHI Regions - AMPHI 6-CysArgCysSerGluSerIleArgArgIleArgArgAsn-18 77-LeuGlyTyrValPheLysProLeuAlaValPheVal-88 106-GlnGlyPheGlyGlnLeuHis-112 132-ThrArgGlnLeuArgGlyPheLys-139 143-PheAspValPheGlnValPheGlyAsn-151 170-GlnPheValGluHisHis-175 177-AspAlaGlyGluValGlyArgValValGlyArgGlyTyrGlyAlaAlaValPheAspPhePheGlnArgPhe GlnLeu-202 205-ValGlnSerGlnArgArgGlyArgHisLeuGluAspPheGlyAsp-219 254-ValGlyLysLeuAspGlnPheAspGlyVal-263 275-PheAspHisIleAlaGluValAlaAsp-283 Antigenic Index - Jameson-Wolf 6-CysArgCysSerGluSerIleArgArgIleArgArgAsnGlyArgGluTrpArgIleLysGlyGlnLysCysAr gLeuAsnThrAspThrValGln-37 89-GlyGlyPheAspGlyArgProValAspIleGlyLysAlaArgPheLeu-104 120-AlaValAspAspGlyLysIle-126 131-AlaThrArgGlnLeuArgGlyPheLysLeuAspAspPheAspVal-145 153-ArgPheGlyCysGlyGlnArgIleAspAla-162 174-HisHisGlnAspAlaGlyGluValGlyArgValValGlyArgGlyTyr-189 204-ArgValGlnSerGlnArgArgGlyArgHisLeuGluAspPheGlyAsp-219 236-GluAspValAspVal-240 255-GlyLysLeuAspGlnPheAspGly-262 279-AlaGluValAlaAspGlyArgAlaGluAspAspPhePhePhe-292 295-AlaValValGlyGlyGlyArgSerGlyCysGlyGlyArg-307 313-AlaAlaGlyGlyGluAspGluArgGluCysGlyGlyGlyLysGlyPheGluGlu-330 Hydrophilic Regions - Hopp-Woods 7-ArgCysSerGluSerIleArgArgIleArgArgAsnGlyArgGluTrpArgIleLysGlyGlnLysCysArgLe uAsnThr-33 91-PheAspGlyArgProValAspIleGlyLys-100 120-AlaValAspAspGlyLysIle-126 131-AlaThrArgGlnLeuArgGlyPheLysLeuAspAspPheAsp-144 174-HisHisGlnAspAlaGlyGluValGlyArgValValGly-186 206-GlnSerGlnArgArgGlyArgHisLeuGluAspPheGlyAsp-219 236-GluAspValAspVal-240 255-GlyLysLeuAspGlnPheAsp-261 279-AlaGluValAlaAspGlyArgAlaGluAspAspPhePhePhe-292 299-GlyGlyArgSerGlyCysGly-305 315-GlyGlyGluAspGluArgGluCysGlyGly-324 326-LysGlyPheGluGlu-330 a694 AMPHI Regions - AMPHI 82-ArgGlyArgAlaCysArg-87 116-CysArgHisPheAlaGln-121 123-ValAlaValGlyArgIleGly-129 140-PheCysGlnLeuPheAsp-145 156-AspIlePheLeuVal-160 162-IleAlaAspIleGlyGlu-167 184-ArgGlyLeuAlaAspIleGlyGluPheValGlyValSerAsp-197 251-HisGlnArgAlaSerArgIleLys-258 283-ArgAlaArgArgHisPheArgGlnValPheAsn-293 311-AspPheValAlaHisIle-316 340-AlaAlaArgIleGly-344 Antigenic Index - Jameson-Wolf 3-SerAlaSerGlyThrArgGlnLysCysArgLeuLysProVal-16 23-ProLysHisSerThrProAlaSer-30 47-GlyGlnAspGluHisAsnAla-53 66-ProProSerAlaTyrGly-71 79-HisPheGlyArgGlyArgAlaCysArgTyr-88 110-ArgIleAspSerAlaArgCysArgHis-118 127-ArgIleGlyArgThrAspHisAsnHisAsp-136 144-PheAspGlyGlyLeuProValGlyArgArgIleAla-155 163-AlaAspIleGlyGluThrArgValGlnArgGlyAspAspValPhe-177 180-IleAspArgGluArgGlyLeuAlaAsp-188 202-HisIleSerAspArgPheAspGlnLysHisPheAlaArgArgLysLeuProHisArgSerPheAspLeu-22 4 228-LeuMetProAspHiΞAspAspPheThr-236 250-ArgHisGlnArgAlaSerArgIleLysHisAlaGluThrAlaLeu-264 268-LeuProHisArgLeuArgTyrAla-275 280-AsnGlnCysArgAlaArgArgHisPhe-288 291-ValPheAsnLysHisArgThr-297 316-IleAsnArgArgAlaGluLeu-322 326-ThrPheAspAsnThrAspCysPro-333 336-ThrSerAlaGluAlaAlaArgIleGlyLysAspAspGlyPhe-349 370-TyrGlyGlyArgCysCysProThrProProThrProHisArgArgArg-385 Hydrophilic Regions - Hopp-Woods 5-SerGlyThrArgGlnLysCysArgLeuLysPro-15 47-GlyGlnAspGluHisAsnAla-53 81-GlyArgGlyArgAlaCysArg-87 110-ArgIleAspSerAlaArgCysArgHis-118 127-ArgIleGlyArgThrAspHisAsnHis-135 150-ValGlyArgArgIleAla-155 163-AlaAspIleGlyGluThrArgValGlnArgGlyAspAsp-175 180-IleAspArgGluArgGlyLeuAlaAsp-188 202-HisIleSerAspArgPheAspGlnLysHisPheAlaArgArgLysLeuProHisArgSerPheAspLeu-22 4 230-ProAspHisAspAsp-234 250-ArgHisGlnArgAlaSerArgIleLysHisAlaGluThrAlaLeu-264 280-AsnGlnCysArgAlaArgArgHisPhe-288 292-PheAsnLysHisArg-296 316-IleAsnArgArgAlaGluLeu-322 327-PheAspAsnThrAsp-331 338-AlaGluAlaAlaArgIleGlyLysAspAspGly-348 380-ThrProHisArgArgArg-385 a695 AMPHI Regions - AMPHI 36-HisProGlnArgPheSerLysProAlaGluArgTyrAlaAspCysProHis-52 85-CysSerSerProValSerArgAsn-92 119-AspArgLeuAspTyr-123 129-ValArgLeuSerAsnGluValGlu-136 144-AlaLeuGluHisAla-148 158-ValGlnLysLeuAsp-162 183-ValGluThrAlaGlnAsnLeuTyrAsnGlnAlaLeuLysHisTyrLysSerGly-200 205-AlaAlaSerLeuLeuLysGlyAla-212 238-CysGluSerValIleGluIle-244 248-TyrAlaAsnArgPheLysAspSer-255 278-AlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGly-291 Antigenic Index - Jameson-Wolf 5-CysProAlaArgArgHisHisCysHis-13 17-PheValGluArgLysGlyAspAlaArgSerGlyPhe-28 31-AlaAlaGlnArgArgHisProGlnArgPheSerLysProAlaGluArgTyrAlaAspCysProHisHisProA laArgArgArgArgPheAspProAlaSerGluLysIleMetLysThrLys-71 87-SerProValSerArgAsnIleGlnAspMetArgLeuGluProGlnAlaGluAlaGlySerSerAspAlaIleP roTyr-112 117-LeuGlnAspArgLeuAspTyr-123 131-LeuSerAsnGluValGluThrLeuAsnGlyLysValLysAlaLeuGluHisAlaLysThrHisProSerSer ArgAlaTyrValGlnLysLeuAspAspArgLysLeuLysGlu-168 170-TyrLeuAsnThrGluGlyGlySerAla-178 193-AlaLeuLysHisTyrLysSerGlyArgPhe-202 210-LysGlyAlaAspGlyGlyAspGlyGlySerIleAlaGln-222 230-GlnSerArgAlaArgMetGlyAsnCys-238 244-IleGlyGlyArgTyrAlaAsnArgPheLysAspSerProThrAlaPro-259 266-GlyGluCysGlnTyr-270 272-LeuGlnGlnLysAspIleAla-278 289-TyrProGlySerProAlaAlaLysArgAlaAlaAlaAlaValArgLysArg-305 Hydrophilic Regions - Hopp-Woods 5-CysProAlaArgArgHisHisCys-12 17-PheValGluArgLysGlyAspAlaArgSerGlyPhe-28 31-AlaAlaGlnArgArgHisProGlnArgPheSerLysProAlaGluArgTyrAlaAsp-49 51-ProHisHisProAlaArgArgArgArgPheAspProAlaSerGluLysIleMetLysThrLys71 88-ProValSerArgAsnIleGlnAspMetArgLeuGluProGlnAlaGluAlaGlySerSerAsp-108 117-LeuGlnAspArgLeuAspTyr-123 131-LeuSerAsnGluValGluThrLeuAsnGlyLysValLysAlaLeuGluHisAlaLysThrHisProSerSer -154 157-TyrValGlnLysLeuAspAspArgLysLeuLysGlu-168 195-LysHisTyrLysSerGlyArgPhe-202 210-LysGlyAlaAspGlyGlyAspGlyGlySerIleAlaGln-222 231-SerArgAlaArgMetGlyAsn-237 248-TyrAlaAsnArgPheLysAspSerProThrAlaPro-259 266-GlyGluCysGlnTyr-270 272-LeuGlnGlnLysAspIleAla-278 293-ProAlaAlaLysArgAlaAlaAlaAlaValArgLysArg-305 a696 AMPHI Regions - AMPHI 18-PheGlyGlyIlePheHisPheValCysArgPheLeuSerArgValGlySerPheValGlnSerIlePheSerC ysPheSer-44 65-IlePheAspLeuValPhe-70 94-GlyLeuAsnArgPheLeuAsnLeuLeuPheGlyPheLeuArg-107 Antigenic Index - Jameson-Wolf 12-CysGlnGlyAsnLysLeu-17 73-PheAspGlyArgSerGlyArgLeuGlyGlyArgSerArgSer-86 108-ThrSerCysGlnGlySerArgHisHisCysGlyAsnGln-120 Hydrophilic Regions - Hopp-Woods 73-PheAspGlyArgSerGlyArgLeuGlyGlyArgSerArgSer-86 109-SerCysGlnGlySerArgHisHisCys-117 a700 AMPHI Regions - AMPHI 6-ThrLeuLeuSerValLeuIleProMetPheAlaGlyPhePheIleArgValProLys-24 27-LeuProAlaLeuAspLysValLeuSerValLeu-37 51-ArgValGluAspLeuGlySerArg-58 80-AlaLeuAlaValLeuGlyLysLeu-87 191-SerTrpValLysGlyLeu-196 204-TrpTyrSerLeuSerGlyLeuVal-211 216-TyrGlyAlaValTrpGlySerIleAlaLeuLeuAsnAspLeuAlaArgGluLeu-233 267-ArgGlyAlaGlyGlyLeu-272 Antigenic Index - Jameson-Wolf 21-ArgValProLysProTyrLeu-27 50-SerArgValGluAspLeuGlySerArgLeuAspAspMetAla-63 90-TrpArgIleLysGlyLysGlyLysGlyVal-99 118-AlaSerGlyLysLeuMetArg-124 128-MetProSerGluAsnAlaGlyMet-135 149-LeuLysSerSerGlyValSerLeu-156 160-LeuValAsnArgArgGlyIleArgLeu-168 245-ArgPheProAspAla-249 268-GlyAlaGlyGlyLeuGluAla-274 Hydrophilic Regions - Hopp-Woods 50-SerArgValGluAspLeuGlySerArgLeuAspAspMetAla-63 92-IleLysGlyLysGlyLysGlyVal-99 149-LeuLysSerSerGlyValSer-155 160-LeuValAsnArgArgGly11eArg-167 a701 AMPHI Regions - AMPHI 6-PheGlnValAlaGly-10 45-ProAsnSerPheAlaSerPheLysArgPheSerSerIle-57 Antigenic Index - Jameson-Wolf 18-GlnSerThrProSerSerProThr-25 33-ThrSerProGluAlaGly-38 52LysArgPheSerSerIleSer-58 72-GlyLysAlaAspIleProThr-78 105-LysAlaSerLeuAsnAsnArgAlaThrSerSer-115 119-SerGlySerGlyThrArgLeu-125 Hydrophilic Regions - Hopp-Woods 72-GlyLysAlaAspIle-76 107-SerLeuAsnAsnArgAlaThrSer-114 a702 AMPHI Regions - AMPHI 51-CysSerGlyLeuValThrVal-57 118-LysIleSerArgGly-122 Antigenic Index - Jameson-Wolf l-MetProCysSerLysAlaSer-7 28-LeuAlaArgAspSerCysSerProGlyLeu-37 41-ThrAlaProAlaSerSer-46 68-LeuAlaIleArgArgMetAlaSerArgProThrGlyValArgArgValIleSer-85 88-GlyMetProProSerThrArgAlaTrpAspLysSerMetAla-101 118-LysIleSerArgGlyValSer-124 139-ArgTrpAspArgLeu-143 Hydrophilic Regions - Hopp-Woods 29-AlaArgAspSerCysSer-34 69-AlaIleArgArgMetAlaSerArgProThrGlyValArgArgValIleSer-85 94-ArgAlaTrpAspLys-98 139-ArgTrpAspArgLeu-143 a703 AMPHI Regions - AMPHI 21-GlnThrLeuAlaThrValAsnGly-28 64-GluValValAsnThrValValAlaGlnGlu-73 79-LeuAspArgSerAlaGlu-84 140-AlaAlaTyrAspAsnlleSerGlyPheTyrLysGly-151 181-PheAspAlaValLeu-185 204-ValProLeuLysAspLeuGluGlnGlyValProProLeuTyrGlnAlaIleLysAspLeuLysLys-225 252-ValProSerPheAsp-256 270-ArgIleAspArgAlaValGlyAlaLeu-278 Antigenic Index - Jameson-Wolf l-MetLysAlaLysIle-5 26-ValAsnGlyGlnLysIleAspSerSerVal-35 43-PheArgAlaGluAsnSerArgAlaGluAspThrProGlnLeuArg-57 72-GlnGluValLysArgLeuLysLeuAspArgSerAlaGluPheLysAsnAlaLeuAlaLysLeuArgAlaGluA laLysLysSerGlyAspAspLysLysProSerPheLysThr-109 129-LysThrGlnProValSerGluGlnGluValLysAlaAlaTyr-142 144-AsnIleSerGlyPheTyrLysGlyThrGlnGluValGlnLeu-157 160-IleLeuThrAspLysGluGluAsnAlaLysLysAlaValAlaAspLeuLysAlaLysLysGlyPhe-181 188-TyrSerLeuAsnAspArgThrLysGlnThrGlyAlaProValGly-202 207-LysAspLeuGluGlnGlyValProPro-215 221-LysAspLeuLysLysGlyGluPheThrAlaThrProLeuLysAsnGlyAspPhe-238 243-TyrValAsnAspSerArgGluValLysValProSerPheAspGluMetLysGly-260 266-LeuGlnAlaGluArgIleAspArgAlaVal-275 282-AlaAsnIleLysProAlaLys-288 Hydrophilic Regions - Hopp-Woods l-MetLysAlaLysIle-5 29-GlnLysIleAspSerSerVal-35 43-PheArgAlaGluAsnSerArgAlaGluAspThrProGlnLeuArg-57 72-GlnGluValLysArgLeuLysLeuAspArgSerAlaGluPheLysAsnAlaLeuAlaLysLeuArgAlaGluA laLysLysSerGlyAspAspLysLysProSerPhe-107 131-GlnProValSerGluGlnGluValLysAlaAlaTyr-142 160-IleLeuThrAspLysGluGluAsnAlaLysLysAlaValAlaAspLeuLysAlaLysLysGlyPhe-181 189-SerLeuAsnAspArgThrLysGlnThrGly-198 207-LysAspLeuGluGln-211 221-LysAspLeuLysLysGlyGluPhe-228 245-AsnAspSerArgGluValLysValProSerPheAspGluMetLysGly-260 266-LeuGlnAlaGluArgIleAspArgAlaVal-275 282-AlaAsnIleLysProAlaLys-288 a704 AMPHI Regions - AMPHI 33-GlyCysGlnAlaValAlaGlnSerIleIleAspAlaGlyLeuGly-47 65-GlnGluIleLeuAspGlnIleArgLeuTyrAspLeuProGluValGlnSerAspPheValGluThrHis-87 184-LeuGlyMetMetGln-188 208-LeuGlnIleLeuHisTrpGlyGlyPheLeuMetValLeuPro-221 232-GlnGlyAlaLeuArgAspLeuLys-239 252-AlaIleIleMetThrPheIleAlaGlyValTyrSer-263 289-PheMetGluHisIleAlaArg-295 298-AlaGlyAspAlaAlaGluArgLeuValLysLeuIleProAlaPheCysHisHisMetProAspTyrProAsp ThrGlnGluThr-325 400-GlyGlyThrArgLeuSerHisIleValArgLeuLeuAspArgAlaLeuAla-416 423-GluLeuAlaGluGlnTyr-428 499-AlaIleGluThrLeuAlaGln-505 527-IleSerLeuLeuArg-531 576-LeuAsnArgIleGlyGluGlyValGly-584 639-LeuLysAspSerAlaAlaGluAlaValArgGlnLeuAla-651 670-GluThrAlaArgAlaLeuGlyVal-677 691-GluTyrValLysAlaLeuGlnLysGlu-699 744-AspLeuArgThrValAlaHisLeuLeuAsp-753 780-AlaValLeuGlyTyrValGlnProTrpIleAlaAla-791 799-LeuAlaValLeuGly-803 805-AlaLeuArgLeuHisLysArg-811 Antigenic Index - Jameson-Wolf l-MetLysLysThrCys-5 9-GlyLeuAspValProGluAsn-15 21-ArgTyrGluAsnGluAspArgGluThrCysCys-31 46-LeuGlySerTyrTyrLysGlnArgThrAlaAspAlaGlnLysThrGluLeuProProGlnGluIleLeuAsp- 69 77-ProGluValGlnSerAspPheValGluThrHisGlyGlyThrArgGluAla-93 112-GlnLeuLeuArgThrAspGlyIleVal-120 124-LeuAsnTyrSerThrHisArgCys-131 133-ValValTrpAspAspGlyLysIleArgLeu-142 158-ProTyrAspAlaGlnLysIleGluAlaAlaAsnGlnLysGluArgLysGlnTyr-175 199-TyrGlyGlyAspIleGluProAspPhe-207 234-AlaLeuArgAspLeuLysAsnArgArgValGlyMetAspThrProIle-249 293-11eAlaArgArgLysAlaGlyAspAlaAlaGluArgLeuVa1-306 316-MetProAspTyrProAspThrGlnGluThrCysGlu-327 329-AlaValValLysLeuLysAlaGlyAsp-337 342-LysProGlyGluThrIleProValAspGlyThrVal-353 356-GlySerSerAlaValAsnGluSer-363 365-LeuThrGlyGluSer-369 374-LysMetProSerGluLysValThrAla-382 393-IleArgThrAspArgThrGlyGlyGlyThrArg-403 414-AlaLeuAlaGlnLysProArgThrAlaGluLeuAlaGlu-426 486-ThrLeuAlaArgGluGlyIle-492 495-GlyGlyLysGlnAlaIle-500 510-1lePheAspLysThrGlyThrLeuThrGlnGlyLysProAlaValArgArg-526 528-SerLeuLeuArgGlyThrAspGluAlaPhe-537 545-LeuGluGlnGlnSerGluHisProLeu-553 560-CysArgIleSerAspGlySerValPro-568 570-IleAlaIleLysGlnArgLeuAsnArgIleGlyGluGlyVal-583 589-ValAsnGlyGluThrGln-594 605-AlaGluIleSerGlyLysGluProGlnThrGluGlyGlyGlySer-619 635-LeuGlnAspProLeuLysAspSerAlaAlaGluAlaValArg-648 650-LeuAlaGlyLysAsnLeu-655 659-11eLeuSerGlyAspArgGluThrAlaVal-668 684-AlaMetProGluAspLysLeuGluTyr-692 694-LysAlaLeuGlnLysGluGlyLysLys-702 707-GlyAspGlyIleAsnAspAla-713 725-AlaAlaGlyGlyThrAspIleAlaArgAspGlyAlaAsp-737 743-GluAspLeuArgThr-747 753-AspGlnAlaArgArgThrArgHisIleIle-762 807-ArgLeuHisLysArgGlyLysMetGlnSerGluLysMetProSerGluGln-823 Hydrophilic Regions - Hopp-Woods l-MetLysLysThrCys-5 21-ArgTyrGluAsnGluAspArgGluThrCys-30 50-TyrLysGlnArgThrAlaAspAlaGlnLysThrGluLeuProPro-64 77-ProGluValGlnSerAspPheValGlu-85 87-HisGlyGlyThrArgGluAla-93 112-GlnLeuLeuArgThrAspGlyIleVal-120 133-ValValTrpAspAspGlyLysIleArgLeu-142 160-AspAlaGlnLysIleGluAlaAlaAsnGlnLysGluArgLysGlnTyr-175 201-GlyAspIleGluProAspPhe-207 234-AlaLeuArgAspLeuLysAsnArgArgValGlyMe -245 293-IleAlaArgArgLysAlaGlyAspAlaAlaGluArgLeuVal-306 318-AspTyrProAspThrGlnGluThrCysGlu-327 329-AlaValValLysLeuLysAlaGlyAsp-337 375-MetProSerGluLysValThr-381 393-IleArgThrAspArgThrGlyGlyGlyThrArg-403 414-AlaLeuAlaGlnLysProArgThrAlaGluLeuAlaGlu-426 486-ThrLeuAlaArgGluGlyIle-492 518-ThrGlnGlyLysProAlaValArgArg-526 531-ArgGlyThrAspGlu-535 545-LeuGluGlnGlnSerGluHisProLeu-553 561-ArgIleSerAspGlySerVal-567 570-IleAlaIleLysGlnArgLeuAsnArgIleGlyGlu-581 607-1leSerGlyLysGluProGlnThrGluGlyGlyGly-618 637-AspProLeuLysAspSerAlaAlaGluAlaValArg-648 661-SerGlyAspArgGluThrAlaVal-668 684-AlaMetProGluAspLysLeuGluTyr-692 694-LysAlaLeuGlnLysGluGlyLysLys-702 730-AspIleAlaArgAspGlyAlaAsp-737 743-GluAspLeuArgThr-747 753-AspGlnAlaArgArgThrArgHisIleIle-762 807-ArgLeuHisLysArgGlyLysMetGlnSerGluLysMetProSerGluGln-823 a705 AMPHI Regions - AMPHI 67-LysIleLeuLeuLysLeu-72 104-AspProIleProAla-108 147-TyrMetGlnThrPheArgArgIleValAlaProGln-158 169-AsnGluPheIleGlyLeuPheLysAsn-177 183-ValValThrValThrGluLeuPheArgValAlaGln-194 196-ThrAlaAsnArgThr-200 Antigenic Index - Jameson-Wolf 13-ThrGluThrArgAlaAspMet-19 132-ValProLysGlyGlnTrpGlu-138 165-ProProLeuSerAsnGlu-170 193-AlaGlnGluThrAlaAsnArgThrTyrAsp-202 226-AlaArgLeuGluLysArgPheAspArgTyrValAla-237 Hydrophilic Regions - Hopp-Woods 13-ThrGluThrArgAlaAspMet-19 193-AlaGlnGluThrAlaAsnArgThr-200 226-AlaArgLeuGluLysArgPheAspArgTyrValAla-237 a706 AMPHI Regions - AMPHI 9-LeuValSerArgTrpLeuAsnSerTyr-17 24-ArgLeuIleHisAlaValArg-30 70-IleTyrSerLysAlaValGluArgMetLeuGlyThrValIleGly-84 Hl-ThrAlaSerAlaLeuAlaGlyTrpAlaAla-120 153-ArgAlaMetAsnValLeu-158 183-LeuAlaAspAsnLeuThrAspCysSerLysMetIleAlaGluIleSerAsnGlyArg-201 204-ThrArgGluArgLeuGluGluAsn-211 243-MetGluAlaMetGlnHisAlaHisArgLysIleVal-254 318-AlaLeuAlaGluHisLeuHis-324 Antigenic Index - Jameson-Wolf l-MetAsnThrSerGlnArgAsnArgLeu-9 H-SerArgTrpLeuAsnSerTyrGluArgTyrArgTyrArgArg-24 73-LysAlaValGluArgMetLeu-79 97-HisTyrPheHisGlyAsnLeu-103 122-GlyLysAsnGlyTyrVal-127 140-GlyAspAsnGlySerGluTrpPheAsp-1 8 186-AsnLeuThrAspCysSerLysMetIleAlaGluIleSerAsnGlyArgArgMetThrArgGluArgLeuGlu GluAsnMetAlaLysMetArgGlnIleAsn-219 221-ArgMetValLysSerArgSerHisLeuAlaAlaThrSerGlyGluSerArgIleSer-239 249-AlaHisArgLysIleValAsn-255 266-LysLeuGlnSerProLysLeuAsnGlySerGluIleArgLeuLeuAsp-281 300-GlyArgHisAlaArgArgIleArgIleAspThrAlaIleAsnProGluLeuGluAlaLeuAla-320 334-SerThrAsnMetArgGlnGluIle-341 349-GlnArgThrArgArgLysTrpLeuAspAlaHisGluArgGlnHisLeu-364 367-SerLeuLeuGluThrArgGluHisSer-375 Hydrophilic Regions - Hopp-Woods 3-ThrSerGlnArgAsnArgLeu-9 17-TyrGluArgTyrArgTyrArgArg-24 73-LysAlaValGluArgMetLeu-79 142-AsnGlySerGluTrpPhe-147 186-AsnLeuThrAspCysSerLysMetIleAla-195 198-SerAsnGlyArgArgMetThrArgGluArgLeuGluGluAsnMetAlaLysMetArgGlnIleAsn-219 221-ArgMetValLysSerArgSerHis-228 232-ThrSerGlyGluSerArgIle-238 249-AlaHisArgLysIleValAsn-255 266-LysLeuGlnSerProLysLeuAsnGlySerGluIleArgLeuLeuAsp-281 301-ArgHisAlaArgArgIleArgIle-308 314-ProGluLeuGluAlaLeuAla-320 336-AsnMetArgGlnGluIle-341 349-GlnArgThrArgArgLysTrpLeuAspAlaHisGluArgGlnHisLeu-364 367-SerLeuLeuGluThrArgGluHisSer-375 a707 AMPHI Regions - AMPHI 16-AsnLeuSerArgLeuGlnLysAla-23 98-GluGlnGlyLeuGluAsnLeuArgArgLeuProSerVal-110 147-GlyGlyLysThrThrGlyLysTyr-154 222-ArgTyrHisGluAlaThrGlu-228 267-ThrArgGlnThrTyrLysTyrIleAspAsp-276 467-HisLysProLysGlyPheGlnThrThrAsnThr-477 Antigenic Index - Jameson-Wolf l-XxxLysGluThrAlaPhe-6 13-GlySerAsnAsnLeuSerArgLeuGlnLysAlaAla-24 42-ProGlnAsnMetAspSerGlyIleLeu-50 53-ArgValSerAlaGlyGluIleGlyAspIleArgTyrGluGluLysArgAspXxxLysSerAlaGluGlySerI le-77 79-AlaPheAsnAsnLysXxxProLeuTyrArgAsnLysIleLeuAsn-93 95-ArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSerValLysThrAspIle-114 117-IleProSerGluGluGluGlyLysSerAspLeu-127 130-LysTrpGlnGlnAsnLysProIleArg-138 141-IleGlyIleAspAspAlaGlyGlyLysThrThrGlyLysTyrGlnGly-156 162-XxxAspAsnProLeuGlyLeuSer-169 180-LeuValHisLysThrAspLeuThrXxxAlaThrGlyThrGluThrGluSerGlySerArgSerTyr-201 216-PheAsnHisAsnGlyHisArgTyrHisGluAlaThrGluGlyTyrSerValAsnTyrAspTyrAsnGlyLys GlnTyrGln-242 269-GlnThrTyrLysTyrIleAspAspAlaGluIleGluValGlnArgArgArgSerAlaGlyTrpGluAlaGlu LeuArgHis-295 303-GlnLeuAspGlyLysLeuSerTyrLysArgGlyThrGlyMetArgGlnSerMetProAlaProGluGluAsn GlyGlyGlyThrIleProXxxXxxSerArgMetLysIle-339 366-GlnTrpAsnLysThrPro-371 374-AlaGlnAspLysLeuSerIleGlySerArgTyrThrValArgGlyPheAspGlyGluGlnSerLeuPheGly GluArgGlyPheTyrTrpGlnAsnThr-406 421-AlaAspTyrGlyArgValSerGlyGluSerAla-431 434-ValSerGlyLysGln-438 446-PheArgGlyGlyHisLysValGlyGly-454 464-LysProLeuHisLysProLysGlyPheGln-473 Hydrophilic Regions - Hopp-Woods l-XxxLysGluThrAlaPhe-6 16-AsnLeuSerArgLeuGlnLysAlaAla-24 58-GluIleGlyAspIleArgTyrGluGluLysArgAspXxxLysSerAlaGluGlySer-76 95-ArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSerValLysThrAspIle-114 118-ProSerGluGluGluGlyLysSerAspLeu-127 141-IleGlyIleAspAspAlaGlyGlyLysThrThrGlyLysTyr-154 180-LeuValHisLysThrAspLeu-186 190-ThrGlyThrGluThrGluSerGlySerArgSer-200 222-ArgTyrHisGluAlaThrGlu-228 273-TyrIleAspAspAlaGluIleGluValGlnArgArgArgSerAlaGlyTrp-289 291-AlaGluLeuArgHis-295 306-GlyLysLeuSerTyrLysArgGlyThrGlyMetArgGlnSerMetProAlaProGluGluAsnGlyGly-32 8 333-XxxXxxSerArgMetLysIle-339 374-AlaGlnAspLysLeuSerIle-380 388-GlyPheAspGlyGluGln-393 422-AspTyrGlyArgValSerGlyGluSer-430 465-ProLeuHisLysProLysGly-471 a708 AMPHI Regions - AMPHI 26-ProSerArgAlaGluLysAlaAsnGlnValSerAsnIle-38 57-AlaSerIleGluAspAlaLeuLysSerAspPro-67 79-IleTyrGlnTyrLeuLys-84 89-AlaGlnGluSerPhe-93 119-AsnArgProAlaGluSerMetAla-126 128-PheAspLysAlaLeu-132 142-IleAlaAsnLeuAsnLys-147 176-ProAlaPheLysGluLeuAlaArg-183 221-LysAlaLeuGlyAsnAlaGln-227 Antigenic Index - Jameson-Wolf 2-ProPheLysProSerLysArgIleSer-10 19-AlaCysSerThrSerTyrArgProSerArgAlaGluLysAlaAsnGln-34 46-TyrMetArgGlyGlnAspTyrArgGlnXxxThrAlaSerIleGluAspAlaLeuLysSerAspProLysAsnG lu-70 84-LysValAsnAspLysAlaGlnGluSerPheArg-94 97-LeuSerIleLysProAspSerAlaGluIleAsnAsnAsnTyr-110 115-CysGlyArgLeuAsnArgProAlaGlu-123 131-AlaLeuAlaAspProThrTyrProXxx-139 146-AsnLysGlyIleCysSerAlaLysGlnGlyGln-156 176-ProAlaPheLysGluLeuAlaArgThrLysMet-186 191-LeuGlyAspAlaAspTyrTyrPheLysLysTyrGlnSerArgValGluValLeuGlnAlaAspAspLeu-21 3 240-PheProTyrSerGluGluLeuGln-247 Hydrophilic Regions - Hopp-Woods 4-LysProSerLysArgIle-9 24-TyrArgProSerArgAlaGluLysAlaAsnGln-34 46-TyrMetArgGlyGlnAspTyrArgGlnXxxThrAlaSerIleGluAspAlaLeuLysSerAspProLysAsnG lu-70 84-LysValAsnAspLysAlaGlnGluSerPheArg-94 99-IleLysProAspSerAlaGluIle-106 117-ArgLeuAsnArgProAlaGlu-123 149-IleCysSerAlaLysGlnGly-155 177-AlaPheLysGluLeuAlaArgThrLysMet-186 201-TyrGlnSerArgValGluValLeuGlnAlaAspAspLeu-213 a709 AMPHI Regions - AMPHI 6-SerLeuLeuAspMetProArgGlyGlu-14 18-ValValValAlaLeuIleAlaAlaMetGly-27 37-ProHisMetSerIleIleAlaAlaIleValValLeu-48 54-AlaArgGlyLeuLysTyrAsn-60 64-GlnGlyMetIleGlyAlaLeuAsnGlnGly-73 115-SerAlaPheAlaLeuCysSerVal-122 130-SerLeuThrThrCysAlaThrVal-137 168-LysMetSerProLeuSerAspThrXxx-176 185-1leAspLeuPheGluHisIleLysAsnMetMetTyrThrThr-198 209-MetLeuXxxLeuLeuPro-214 221-LeuAsnSerValGluSerPheArg-228 234-ThrGlyLeuValHisCysTyrSerLeuIleProPheAlaLeuLeuValValLeu-251 261-AlaMetLeuPheThrValIleAlaAlaValAlaValThrTyr-274 278-ThrProAspLeuArgGlnLeuGlyAlaTrpPhe-288 299-XxxXxxAspIleAlaLysLeuIleSerArgGlyGly-310 334-LeuGlyAlaIleProSerLeuLeuAspAlaValArgSerPheLeuThr-349 382-ThrPheLysProVal-386 395-ArgAsnLeuSerArgThrLeuGluAspAlaGlyThrValIleAsnProLeuValProTrpSerValCysGly ValPheIleXxxHis-423 Antigenic Index - Jameson-Wolf 9-AspMetProArgGlyGluAla-15 55-ArgGlyLeuLysTyrAsnAspMetGln-63 164-XxxXxxGlyXxxLysMetSerProLeuSerAspThrXxxGlyXxxSer-179 222-AsnSerValGluSerPheArgSerGlnLeuGlu-232 277-SerThrProAspLeuArgGln-283 290-GlyGlyTyrLysLeuGluGlyGluAlaXxxXxxAspIleAlaLysLeuIleSerArgGlyGlyLeuGlu-31 2 349-ThrAsnAlaGlyArgXxxThr-355 378-LeuSerGlyGluThrPheLysProValTyrAspLysLeuGlyLeuHisSerArgAsnLeuSerArgThrLeu GluAspAlaGlyThr-406 Hydrophilic Regions - Hopp-Woods 9-AspMetProArgGlyGluAla-15 57-LeuLysTyrAsnAspMetGln-63 165-XxxGlyXxxLysMetSerProLeuSerAspThrXxxGly-177 225-GluSerPheArgSerGlnLeuGlu-232 279-ProAspLeuArgGln-283 293-LysLeuGluGlyGluAlaXxxXxxAspIleAlaLysLeuIleSer-307 396-AsnLeuSerArgThrLeuGluAspAlaGly-405 a710 AMPHI Regions - AMPHI 6-LysIleArgLeuMetArgGluLeuAsnLysTrpSerGln-18 31-GlyTyrAlaLysIleGlu-36 45-ProArgLeuGluGlnLeuAlaGlnl1ePheLys11eAspMe TrpAspLeuLeuLys-63 105-CysLysGluMetLeuGlu-llO Antigenic Index - Jameson-Wolf 1-MetGluThrHisGluLysIleArgLeuMetArgGluLeuAsnLysTrpSerGlnGluAspMetAlaGluLysLe uAla-26 33-AlaLysIleGluArgGlyGluThrGlnLeuAsnIleProArgLeuGluGln-49 62-LeuLysSerGlyGlyGlyGly-68 74-AsnAspValAspThrAsnSerGlyGlu-82 88-AlaGlnAspAlaSerGlyLys-94 100-MetGluLeuLysHisCysLysGluMetLeuGluHisLysAspLysGluIleGluLeuLeuArgLysLeuThr Glu-124 Hydrophilic Regions - Hopp-Woods 1-MetGluThrHisGluLysIleArgLeuMetArgGluLeuAsnLysTrpSerGlnGluAspMetAlaGluLysLe uAla-26 33-AlaLysIleGluArgGlyGluThr-40 45-ProArgLeuGluGln-49 74-AsnAspValAspThrAsnSerGly-81 100-MetGluLeuLysHisCysLysGluMetLeuGluHisLysAspLysGluIleGluLeuLeuArgLysLeuThr Glu-124 a711 AMPHI Regions - AMPHI 28-AlaGluSerTyrArgAsnLeuThrAlaSerGluIleAlaLysValTyrThrIleAlaArgMetThr 49 AspLeuAspMetLeuAsnAspIleLys-58 67-SerGlyGlnSerPheAspAspTrpArgLysGlyIleLeu-79 95-GlyLysAspIleIleAspProAlaThrGlyGluValPheGlySerProArgArgLeuGluThrIleTyrArgT hrAsnMet-121 128-GlyGlnTyrGlnGlyTyrMet-134 158-SerAlaIleAspGly-162 195-ValGluArgGlnGly-199 207-SerAspAsnLeuValGluThrHis-214 258-LysTyrAspArgAlaLeuAlaHisGlnPheAla-268 281-PheLysGlnLeuGluLysGluPheTyr-289 329-GlnGluLeuAlaGlyMetThr-335 352-SerArgGluGlyGlnAsnPhe-358 360-AspSerTyrTyrAlaPheLeuProAspMetLeuGlnAsnProGlu-374 395-TrpAlaValLeuLysTyrIleLysGluValAspGluIle-407 413-ArgIleSerAsnAspLysGluIleAlaLys-422 Antigenic Index - Jameson-Wolf ll-SerLeuProProLysLysAlaIleGlu-19 21-LeuGluSerLysLysValThrAlaGluSerTyrArgAsnLeuThr-35 55-AsnAspIleLysThrSerMet-61 63-GluSerAlaLysSerGlyGlnSerPheAspAspTrpArgLysGlyIle-78 82-LeuSerAsnLysGlyTrpLeuHisProAsnGlyHisAsnGlyLysAspIleIleAspProAlaThrGlyGluV alPheGlySerProArgArgLeuGluThrIleTyrArgThrAsnMet-121 126-AsnAlaGlyGlnTyrGlnGly-132 135-AlaAsnIleAspAlaArgProTyrTrp-143 147-AlaValGlyAspSerArgThrArgProAlaHisSerAla-159 165-TyrArgTyrAspAspProPheTrp-172 177-ProProAsnGlyTyrAsnCysArgCysSer-186 190-LeuSerGluArgAspValGluArgGlnGlyArgIleValGlyGlnSerThrSerAspAsnLeuValGlu-21 2 215-LysIleTyrAsnLysLysGlyAspThr-223 229-TyrLysAlaProAspGlySerLeuTyrThrThrAspArgGlyPheAspTyrAsnAlaGlyArgMetAsnTyr ArgProAspLeuAspLysTyrAspArgAlaLeu-263 268-AlaLysAlaGluMetGlyGlyAlaAspPheLysThrSerPheLysGlnLeuGluLysGluPheTyrGluVal LysGlnArgLeuAspIleAspGlyLysProAspLysGluGlnLysIleLysIleArgAsnAlaLeu-313 324-LeuSerLysGluThrGlnGlu-330 342-SerAspAspThrLeuValLysGlnValAspSerArgGluGlyGlnAsnPheAspAspSerTyrTyr-363 370-LeuGlnAsnProGluHisValIleArgAspAsnArgGlu-382 387-AlaArgTyrLysGlySer-392 400-TyrIleLysGluValAspGlu-406 411-SerTyrArgIleSerAsnAspLysGluIleAla-421 424-MetAlaLysLysLysValLeuLys-431 Hydrophilic Regions - Hopp-Woods 13-ProProLysLysAlaIleGlu-19 21-LeuGluSerLysLysValThrAlaGluSerTyrArg-32 55-AsnAspIleLysThrSerMet-61 63-GluSerAlaLysSerGlyGlnSerPheAspAspTrpArgLys-76 93-HisAsnGlyLysAspIleIleAsp-100 108-GlySerProArgArgLeuGluThr-115 147-AlaValGlyAspSerArgThrArgProAla-156 190-LeuSerGluArgAspValGluArgGlnGlyArgIleVal-202 205-SerThrSerAspAsnLeuValGlu-212 215-LysIleTyrAsnLysLysGlyAspThr-223 238-ThrThrAspArgGlyPheAsp-244 250-MetAsnTyrArgProAspLeuAspLysTyrAspArgAlaLeu-263 268-AlaLysAlaGluMetGlyGlyAlaAspPheLysThrSerPheLysGlnLeuGluLysGluPheTyrGluVal LysGlnArgLeuAspIleAspGlyLysProAspLysGluGlnLysIleLysIleArgAsnAlaLeu-313 324-LeuSerLysGluThrGlnGlu-330 344-AspThrLeuValLysGlnValAspSerArgGluGlyGlnAsnPheAsp-359 375-HisValIleArgAspAsnArgGlu-382 400-TyrIleLysGluValAspGlu-406 414-IleSerAsnAspLysGluIleAla-421 424-MetAlaLysLysLysValLeuLys-431 a713 AMPHI Regions - AMPHI 18-GluHisArgHisTrpGlu-23 115-AspAlaAlaLysLysLeuAlaAlaProTrpProGlnIle-127 150-ThrValTrpGlnAlaLeuThrHisIleAlaAsnSerVal-162 257-AspAsnLeuAlaAlaLeuGln-263 265-GlnAlaLysLysGln-269 Antigenic Index - Jameson-Wolf l-MetGlnAsnAsnSerTyrGly-7 13-ArgValGlyGlyLysGluHisArgHisTrpGluArgTyrAspIleAspSerAspPhe-31 44-ArgLeuGlyProGluAlaAlaIleProAspLeuSerGlyGluSerCysGluValValIle-63 74-GlySerGlnArgHisGlyLysSerLysGlyGlyArgGluLeuSerLeuΞerGlyArgAspLeu-94 106-LeuAsnValLysGly-llO 115-AspAlaAlaLysLysLeu-120 134-ValGluAsnAsnProAlaLeuAspLysIleAspIleGluProGlyGluThrVal-151 167-TrpLeuGluProAspGlyThrLeu-174 192-SerArgThrAspSerArgArgAsnIleGluArgMetAspIleGluTrpAspThrAspAsnArgPheSerGlu -215 222-SerHisGlyArgSerGlyAspSerAlaLysHisAspLeu-234 236-TrpValTyrLysAspProThrMetThrLeuHisArgProLysThrValVal-252 254-SerAspAlaAspAsn-258 263-GlnLysGlnAlaLysLysGlnLeuAla-271 284-ValGlyGlyHisLysThrArgAspGly-292 302-HisValIleAspAspGluHisGlyIle-310 321-PheMetLeuSerArgMetAspGlyThrGlnThrGluLeuArgLeuLysGluAspGlyIleTrpThrProAsp AlaTyrProLysLysAlaGluAlaAlaArgLysArgLysGlyLysArgLysGlyValSerHisLysGlyLysLysG lyGlyLysLysGlnAlaGlu-376 Hydrophilic Regions - Hopp-Woods 14-ValGlyGlyLysGluHisArgHisTrpGluArgTyrAspIleAspSer-29 54-LeuSerGlyGluSerCysGluValValIle-63 76-GlnArgHisGlyLysSerLysGlyGlyArgGluLeuSerLeuSerGlyArgAspLeu-94 115-AspAlaAlaLysLysLeu-120 138-ProAlaLeuAspLysIleAspIleGluProGlyGlu-149 168-LeuGluProAspGly-172 193-ArgThrAspSerArgArgAsnIleGluArgMetAspIleGluTrpAspThrAspAsnArgPheSer-214 222-SerHisGlyArgSerGlyAspSerAlaLysHisAspLeu-234 246-HisArgProLysThr-250 254-SerAspAlaAspAsn-258 263-GlnLysGlnAlaLysLysGlnLeuAla-271 286-GlyHisLysThrArgAsp-291 302-HisValIleAspAspGluHisGlyIle-310 325-ArgMetAspGlyThrGlnThrGluLeuArgLeuLysGluAspGlyIleTrp-341 345-AlaTyrProLysLysAlaGluAlaAlaArgLysArgLysGlyLysArgLysGlyValSerHisLysGlyLys LysGlyGlyLysLysGlnAlaGlu-376 a714 AMPHI Regions - AMPHI 6-IleLeuArgGlyLeuLeuPro-12 34-LeuAspAlaValAlaGluSerAlaGlnSerValAlaAspAlaValAspProSer-51 55-GlnMetLeuAlaAspTrpGluArgValLeuGlyLeu-66 79-AlaValMetAlaLysLeuAsnGluThrGly-88 98-LeuAlaGluAlaAla-102 110-GluProGlnProPhe-114 116-AlaGlyValAsnArgAlaGlyAspArgLeu-125 155-AlaGlyAspArgLeuThrAspTyrSerAspAlaValIleGluSerLeuPheAsnArgLeuLys-175 Antigenic Index - Jameson-Wolf 15-SerTyrAlaArgAsnAlaProArgValArgAlaGlnAlaGluIleAspGlyAlaAla-33 36-AlaValAlaGluSerAlaGlnSerVal-44 46-AspAlaValAspProSerSerAlaGly-54 64-LeuGlyLeuAspGlyThrGlyLysAsnArgGlnArgArgVal-77 83-LysLeuAsnGluThrGlyGlyLeu-90 107-GlnIleAspGluProGlnProPheArgAlaGlyValAsnArgAlaGlyAspArgLeuAlaPro-127 138-ValArgGlyGlyAsnAsnArgIleThrArgPheArgAlaGlyIle-152 154-AlaAlaGlyAspArgLeuThrAspTyrSerAspAlaValIle-167 170-LeuPheAsnArgLeuLysPro-176 Hydrophilic Regions - Hopp-Woods 18-ArgAsnAlaProArgValArgAlaGlnAlaGluIleAspGlyAlaAla-33 36-AlaValAlaGluSerAlaGlnSerVal-44 46-AspAlaValAspProSerSer-52 68-GlyThrGlyLysAsnArgGlnArgArgVal-77 107-GlnIleAspGluProGlnProPhe-114 117-GlyValAsnArgAlaGlyAspArgLeuAlaPro-127 139-ArgGlyGlyAsnAsnArgIleThrArgPheArgAla-150 154-AlaAlaGlyAspArgLeuThrAspTyrSerAspAlaValIle-167 170-LeuPheAsnArgLeuLysPro-176 a715 AMPHI Regions - AMPHI 15-GlnIleGluArgLeuGlyAsnGlyIle-23 3 l-ArgArgLeuSerGluThrMetHis-38 64-LeuSerAspSerGlyArgLeuLysAspSerPheSer-75 94-IleHisAsnPheGlyGly-99 Antigenic Index - Jameson-Wolf 15-GlnIleGluArgLeuGlyAsnGlyIleGluAsnArgTyrLeuLeu-29 47-TyrAlaGlyArgProLysTrpLeuGlyLeuLysTyrArgAspGlyLysProLeuSerAspSerGlyArgLeuL ysAspSerPheSerThrLeuSerAspAsnAspThrAla-83 98-GlyGlyMetAlaGlyArgAsnArgLysValArgIleProGlnArgGluPhe-114 118-ThrAspAspAspLysGlnAlaLeuMetAspAspValGlnAsp-131 Hydrophilic Regions - Hopp-Woods 15-GlnIleGluArgLeuGlyAsn-21 57-LysTyrArgAspGlyLysProLeuSerAspSerGlyArgLeuLysAspSerPhe-74 78-SerAspAsnAspThr-82 lOl-AlaGlyArgAsnArgLysValArgIleProGlnArgGlu-113 118-ThrAspAspAspLysGlnAlaLeuMetAspAspValGlnAsp-131 a716 AMPHI Regions - AMPHI 33-GlyValHisLysSerAlaHisGly-40 71-AlaThrValLysLysThrHisLysHisThrLysAla-82 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnIle-5 23-AlaAlaAsnLysProAlaSerAsnAlaThrGlyValHisLysSerAlaHisGlySerCysGlyAlaSerLysS erAlaGluGlySerCysGlyAlaAlaGlySerLysAlaGlyGluGlyLysCysGlyGluGlyLysCysGlyAlaTh rValLysLysThrHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysGlyGluGly LysCysGlySerLys-102 Hydrophilic Regions - Hopp-Woods 23-AlaAlaAsnLysProAlaSer-29 33-GlyValHisLysSerAlaHis-39 43-GlyAlaSerLysSerAlaGluGlySerCys-52 55-AlaGlySerLysAlaGlyGluGlyLysCysGlyGluGlyLysCys-69 71-AlaThrValLysLysThrHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysG lyGluGlyLysCysGlySerLys-102 a717 AMPHI Regions - AMPHI 175-AlaValTyrAlaLeuAlaAsn-181 209-LeuHisArgGlyLeu-213 223-SerIleAlaTyrTrp-227 241-AlaGlyLeuGluGlnLeuGly-247 263-GlnSerIlePheSerThrValTrpThrProTyrIlePheArgAlaIleGluAla-280 305-ThrGlyIlePheSerProLeuAlaSer-313 347-LeuAsnValValArgLysThr-353 358-LeuAlaThrLeuGlyAlaLeuAla-365 401-SerSerCysArgLeuTrpGlnProLeuLysArgLeu-412 430-CysPheGlyThrPro-434 442-GlyValTrpAlaValTyrLeuAla-449 457-LysAspLeuHisLysLeuPheHisTyr-465 Antigenic Index - Jameson-Wolf l-MetAspThrLysGlu-5 32-ProAlaAspAspIleGlyArg-38 69-AlaAspLysAspThrLeu-74 95-SerArgProSerLeuProSerGluIle-103 135-MetGluGlyArgAla-139 192-AsnArgCysArgLeuLysAlaValArgArgAlaProPheSerSer-206 231-SerAlaAspArgLeuPheLeu-237 278-IleGluAlaAsnAlaProProAlaArgLeu-287 289-AlaThrAlaGluSer-293 317-ProGluAsnTyrAla-321 349-ValValArgLysThrArgProIleAla-357 376-ProSerGlyGlyAlaArgGly-382 398-LysThrGluSerSerCysArgLeu-405 453-LeuArgHisArgLysAspLeuHis-460 Hydrophilic Regions - Hopp-Woods l-MetAspThrLysGlu-5 69-AlaAspLysAspThrLeu-74 135-MetGluGlyArgAla-139 192-AsnArgCysArgLeuLysAlaValArgArgAlaProPhe-204 281-AsnAlaProProAlaArgLeu-287 289-AlaThrAlaGluSer-293 349-ValValArgLysThrArgPro-355 378-GlyGlyAlaArgGly-382 399-ThrGluSerSerCys-403 453 -LeuArgHisArgLysAspLeuHis-460 a718-l AMPHI Regions - AMPHI 28-IleThrAlaThrGlyArgValIleAlaGluHisProSerAsnPheIleThrProGln-46 49-ArgAlaLeuPheGlu-53 110-AspGlnAlaTyrGluMetMetAspSerLeuProThr-121 124-AspLeuIleMetAspLeuMetAspAlaValGlyHisGly-136 160-ProGlnSerTrpPheLys-165 198-ArgSerValGlnGln-202 210-ThrLeuSerTrpLeuTyrMetPhe-217 219-HisTyrAlaValHisAspPheAlaGluPheLeuGluLeu-231 255-ArgAlaValAlaGluIle-260 279-AlaAlaAsnGlyMetThrSer-285 320-ThrAsnAlaLeuGlyAsnIleHisAsnGluIleArg-331 341-GlnValAlaGlnThrIleThrSerGlnIleIleGlyProPhe-354 363-AspProAsnArgVal-367 376-GluProLysAspIleAlaValPheAlaAspAlaIleProLysLeuValAsp-392 395-ValGlnIleProGlu-399 420-ArgGlnValProAspAsnPro-426 448-HisGlnGluIleLeuAspGlyAlaLeuAspAsp-458 469-LeuAsnProMetValArgGlnAlaValAlaAlaLeuAsnAlaCysAsnSerTyrGlu-487 Antigenic Index - Jameson-Wolf 4-IleMetAlaLysLysAsnAsnLysThrLysIleGlnLysProGluAlaAlaLeu-21 30-AlaThrGlyArgValIleAla-36 38-HisProSerAsnPhe-42 44-ThrProGlnLysMetArgAlaLeuPheGluAspAlaGluSerGlyAspIleArgAlaGlnHis-64 68-AlaAspIleGluGluArgAspSerAspIle-77 81-MetGlyThrArgLysArgAla-87 95-ValAlaProProArgAsnAlaThrProGluGluGluLysLeuSerAspGlnAlaTyrGluMet-115 119-LeuProThrLeuGlu-123 148-AspGlyLeuTyrLeuProArgAsnPheIleHisArgProGlnSerTrpPheLysTrpAspLysAspAsnGly Leu-172 174-LeuArgThrArgGluAsnProGluGlyGluAla-184 193-HisThrGlnLysSerArgSerValGlnGlnAlaArgAsnGlyLeuPhe-208 237-ArgIleGlyLysTyrGlyAlaGlyAlaThrLysGluGluLysAsnThrLeu-253 268-MetProGluGlyMetGluIleGluLeu-276 280-AlaAsnGlyMetThrSerAla-286 295-AspTrpCysGluLysSerAlaAla-302 310-LeuThrSerGlyAlaAspGlyLysSerSerThrAsnAlaLeuGly-324 328-AsnGluIleArgArgAspLeuLeuValSerAspAlaLysGlnVal-342 359-TyrProHisAlaAspProAsnArgValProLysPheGluPheAspThrArgGluProLysAspIle-380 397-IleProGluSerTrpValArgAspLysLeuVal-407 410-AspValGlnGluGlyGluAlaValLeu-418 420-ArgGlnValProAspAsnProValAsnArg-429 440-ValProSerLysAlaThrGlyArgHisGlnGluIleLeuAspGlyAlaLeuAsp-457 459-AlaLeuValGluProAspPheAsnSerGlnLeu-469 484-AsnSerTyrGluGluAlaAspAla-491 499-AsnLeuAspAsnAlaLysLeuArgThr-507 519-LeuGlyGlnAspHisAlaArgAla-526 Hydrophilic Regions - Hopp-Woods 4-IleMetAlaLysLysAsnAsnLysThrLysIleGlnLysProGluAlaAlaLeu-21 46-GlnLysMetArgAlaLeuPheGluAspAlaGluSerGlyAspIleArgAlaGlnHis-64 68-AlaAspIleGluGluArgAspSerAspIle-77 81-MetGlyThrArgLysArgAla-87 96-AlaProProArgAsnAlaThrProGluGluGluLysLeuSerAspGlnAlaTyrGluMet-115 165-LysTrpAspLysAspAsnGlyLeu-172 174-LeuArgThrArgGluAsnProGluGlyGluAla-184 195-GlnLysSerArgSerValGlnGlnAlaArg-204 245-AlaThrLysGluGluLysAsnThrLeu-253 270-GluGlyMetGluIleGluLeu-276 295-AspTrpCysGluLysSerAlaAla-302 312-SerGlyAlaAspGlyLysSerSerThr-320 328-AsnGluIleArgArgAspLeuLeuValSerAspAlaLysGlnVal-342 363-AspProAsnArgValProLysPheGluPheAspThrArgGluProLysAsp-379 401-TrpValArgAspLysLeuVal-407 410-AspValGlnGluGlyGluAlaValLeu-418 421-GlnValProAspAsnProValAsn-428 440-ValProSerLysAlaThrGlyArgHisGlnGluIleLeuAspGlyAlaLeuAsp-457 485-SerTyrGluGluAlaAspAla-491 501-AspAsnAlaLysLeu-505 522-AspHisAlaArgAla-526 a720 AMPHI Regions - AMPHI 19-GlnAlaValArgLeuLeuSerThrSer-27 46-AlaProAspLeuIleGluValAsn-53 66-AlaLeuArgAlaValGlnThrAla-73 91-GlnThrAlaGluSerLeu-96 102-ArgLeuAsnAlaLeuValAla-108 126-GlyThrIleHisGlnIleAlaHisGluPheTyrGlyAspIleAlaArgAlaAlaGluLeuVal-146 Antigenic Index - Jameson-Wolf l-GlyLeuGlnAsnArgLeuAsnArgLeuThrAlaLysGlnVal-14 39-AlaHisGlyGluGluMetThrAla-46 48-AspLeuIleGluValAsnArgAlaMetArgArgArgMetGlnAla-62 74-AlaAlaGluSerGlyGlyLeuThrAla-82 91-GlnThrAlaGluSerLeuArgAlaAlaAla-100 112-AsnGlnLysProProLeu-117 121-GlnAlaProIleAspGlyThr-127 139-IleAlaArgAlaAlaGlu-144 157-PheIleLysArgGlyThrLeuValAsnSerTyrAlaLys-169 Hydrophilic Regions - Hopp-Woods 4-AsnArgLeuAsnArgLeuThrAla-11 39-AlaHisGlyGluGluMetThrAla-46 48-AspLeuIleGluValAsnArgAlaMetArgArgArgMetGlnAla-62 74-AlaAlaGluSerGlyGly-79 94-GluSerLeuArgAlaAlaAla-100 139-IleAlaArgAlaAlaGlu-144 a721 AMPHI Regions - AMPHI 86-AlaGlyTrpMetArgTrpLeuGlu-93 119-ArgTyrIleSerAlaVal-124 134-SerLysIlePheHisAlaAlaLeuThrAsnPheProAlaLeuAspGlyMetAspGluValLeuAla-155 169-AsnProMetLysGluLeuLeuGlnGlnLeuPheGlyLeu-181 209-AspValPheAlaGln-213 235-LysTyrAlaProIleSerValValGlnGluLeuGln-246 281-TrpAlaGluGlyValLeuLysGlnProGlyGly-291 293-AlaPheLeuThrGlyPheIleGlu-300 Antigenic Index - Jameson-Wolf l-MetSerLysAsnAlaGln-6 16-GluValGlnProLysAspGlyArgIle-24 27-LeuProTyrGlyGlu-31 33-ArgAlaValAspGlyArgProThrAspValProAla-44 48-ThrGluGluAsnGlyHisAsp-54 58-LeuAlaAsnSerSerArgAsnGlnLeu-66 74-LeuTyrLysGluLysAsnGlyGlnProAlaPro-84 93-GluPheThrProLysGlyMetPheAla-101 104-GluTrpThrAspLysAlaAla-llO 114-AlaAlaLysGluTyrArg-119 125-PheSerTyrAspThrLysGlyTyrVal-133 148-AspGlyMetAspGluValLeu-154 160-GlnIleLeuLysProGluThrGluGlnAsnProMetLysGluLeuLeu-175 182-ProAspAlaGlyGluGluGluLeuLysAla-191 197-ValGluAlaLysProLysAspValAlaLeu-206 214-LeuAlaGluLysAspSerArgIle-221 227-GlnThrAlaLysProAspLeuThrLysTyrAla-237 254-AlaLysGlnGluAlaAspLysGlyAsnGlu-263 276-ProAlaGlnLysGluTrpAla-282 285-ValLeuLysGlnProGlyGly-291 310-GlySerGlnThrGlyGlyLysAlaProAspGluArgValAla-323 326-ThrAlaGluGluAlaAlaAla-332 337-GlyMetSerGlyGluGluPheValLysIleLysGluSerGluGlyLys-352 Hydrophilic Regions - Hopp-Woods l-MetSerLysAsnAlaGln-6 17-ValGlnProLysAspGlyArgIle-24 33-ArgAlaValAspGlyArgProThrAsp-41 49-GluGluAsnGlyHis-53 74-LeuTyrLysGluLysAsnGlyGln-81 104-GluTrpThrAspLysAlaAla-llO 114-AlaAlaLysGluTyrArg-119 148-AspGlyMetAspGluValLeu-154 162-LeuLysProGluThrGluGlnAsnProMetLysGluLeuLeu-175 183-AspAlaGlyGluGluGluLeuLysAla-191 197-ValGluAlaLysProLysAspValAlaLeu-206 214-LeuAlaGluLysAspSerArgIle-221 228-ThrAlaLysProAspLeuThrLys-235 254-AlaLysGlnGluAlaAspLysGlyAsnGlu-263 276-ProAlaGlnLysGluTrpAla-282 313-ThrGlyGlyLysAlaProAspGluArgValAla-323 326-ThrAlaGluGluAlaAlaAla-332 339-SerGlyGluGluPheValLysIleLysGluSerGluGlyLys-352 a724 AMPHI Regions - AMPHI 6-LeuAlaLysLysThr-10 12-GlnThrAlaLysAsnIleGlyGluThrLeuArg-22 40-ArgValGlnLeuSer-44 47-AlaAspGluThrLeuGlnAspLeuGluHisLeuGlnGlu-59 Antigenic Index - Jameson-Wolf 5-LysLeuAlaLysLysThrAlaGlnThrAlaLysAsnIleGlyGluThrLeuArgAlaAlaPheArgGlyLysIl e-29 34-SerSerGluProIleGlnArgValGlnLeuSerGlyLeuAlaAspGluThrLeuGlnAspLeuGluHis-56 60-TyrGlyPheAlaSerHisProProAspGlySerGluAla-72 77-LeuGlyGlyAsnThrSer-82 90-GlnHisGlySerTyrArgIleLysAsnLeuLysProGlyGluThr-104 108-AsnHisGluGlyAlaLysIleValIleLysGlnGlyLysIleIleGluAlaAspCysAspVal-128 130-ArgValAsnCysLysGlnTyrGlu-137 142- hrAspAlaLysPhe-146 162-GlnIleAsnGlyAsnGly-167 170-AlaValGluGlyGlyAspGlyAlaThrPheSerGlyAspValAsnGlnThrGlyGlySerPheAsnThrAsp GlyAspValValAla-198 205-GlnHisProHisThrAspSerIleGlyGlyLysThrLeuProAlaGluProAla-222 Hydrophilic Regions - Hopp-Woods 5-LysLeuAlaLysLysThrAlaGlnThrAlaLysAsnIleGlyGluThrLeuArgAlaAlaPheArgGly-27 46-LeuAlaAspGluThrLeuGlnAspLeuGluHis-56 66-ProProAspGlySerGlu-71 94-TyrArgIleLysAsnLeuLysProGlyGlu-103 110-GluGlyAlaLysIleValIleLysGlnGlyLysIleIleGluAlaAspCysAspVal-128 132-AsnCysLysGlnTyrGlu-137 142- hrAspAlaLysPhe-146 190-PheAsnThrAspGlyAspVal-196 207-ProHisThrAspSerIleGly-213 a726 AMPHI Regions - AMPHI 12-AspThrLeuGlySerIleProGlu-19 55-ProArgProSerGluTyrHisGlu-62 74-AlaAlaAlaAlaArg-78 HO-IleAspSerPheTyrArg-115 122-AlaArgGlnAlaAsp-126 137-IleAlaAlaAlaArg-141 180-IleGluThrAlaProGlyLeuAspAlaLeuGluLysGluIleGlu-194 Antigenic Index - Jameson-Wolf 5-PheLysAsnGlyPheTyrAspAspThrLeuGlySerIleProGluGly-20 24-ValArgAlaGluGluTyr-29 37-AlaGlnGlyGlyGlnIleAlaAlaAspSerAspGlyArgProValLeuThrProProArgProSerGluTyrH isGluTrpAspGlyLysLysTrpGluIle-70 78-ArgPheAlaGluGlnLysThr-84 90-LeuAlaAlaLysAlaAspGluLeuLysAsnSer-100 106-ProGlnValGluIleAspSerPheTyrArgGlnGluLysGluAlaLeuAlaArgGlnAlaAspAsnAsnAla ProThr-131 151-LysValValGluLysSerAlaArg-158 167-IleGlyLysArgGlnGlnLeuGluAspLysLeuAsnThr-179 181-GluThrAlaProGlyLeuAspAlaLeuGluLysGluIleGluGlu-195 Hydrophilic Regions - Hopp-Woods 24-ValArgAlaGluGluTyr-29 42-IleAlaAlaAspSerAspGlyArgPro-50 55-ProArgProSerGluTyrHisGluTrpAspGlyLysLysTrpGluIle-70 78-ArgPheAlaGluGlnLysThr-84 90-LeuAlaAlaLysAlaAspGluLeuLysAsn-99 114-TyrArgGlnGluLysGluAlaLeuAlaArgGlnAlaAspAsnAsnAla-129 151-LysValValGluLysSerAlaArg-158 167-IleGlyLysArgGlnGlnLeuGluAspLysLeuAsnThr-179 187-AspAlaLeuGluLysGluIleGluGlu-195 a727 AMPHI Regions - AMPHI 6-LeuLeuAlaAsnAsn-10 12-GlnProIleAlaIleIleAla-18 61-TyrAlaArgGluLeuGlu-66 118-GlyCysIleAspGlyPheGly-124 Antigenic Index - Jameson-Wolf 28-HisHisGlnGlyTyrLysSerAlaPheAlaLysGln-39 41-AlaValIleGluLysMetLysArgAspLysAlaGln-52 60-AsnTyrAlaArgGluLeuGluGlnAlaArgAlaGluAlaLysLysTyrGluValLysAla-79 86-LeuAlaLysLysGlnAlaGluValSerArgLeuLysThrGluAsnLysLysGluIleGluAsn-106 108-LeuThrGlnAspArgLysAsnAlaGlyGlyGlyCysIleAspGlyPheGly-124 135-LeuGlyTyrGlyAsn-139 Hydrophilic Regions - Hopp-Woods 41-AlaValIleGluLysMetLysArgAspLysAlaGln-52 60-AsnTyrAlaArgGluLeuGluGlnAlaArgAlaGluAlaLysLysTyrGluValLysAla-79 86-LeuAlaLysLysGlnAlaGluValSerArgLeuLysThrGluAsnLysLysGluIleGluAsn-106 108-LeuThrGlnAspArgLysAsnAlaGly-116 a728 AMPHI Regions - AMPHI H-SerPhePheAlaLeuValPheAla-18 39-AlaThrGluValProLysAsnPro-46 48-AlaPheValAlaLysLeuAlaArgLeuPheArgAsnAla-60 76-AsnLeuAlaGlyThrValAspAsp-83 198-GluAspValTyrGluHisCysLeuGlyCysTyrGlnMet-210 218-TyrArgAspValAlaAsnAspGlu-225 235-SerAsnArgIleAlaSer-240 249-GlnAsnMetArgGluLeuMetProArg-257 355-GluLysGluValArgArgTyrAlaGluAlaAlaAlaArg-367 Antigenic Index - Jameson-Wolf 29-IleAsnProArgTrp-33 35-LeuSerAspThrAlaThrGluValProLysAsnProAsn-47 57-PheArgAsnAlaAspArgAla-63 69-GluSerIleArgThrGluGluAsnLeuAlaGlyThrValAspAspGlyProLeuGlnSerGluLysAspTyr- 92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyLys-118 125-HisIleGlyGluGlyGly-130 136-LeuSerGlnArgSerProGluAlaPheVal-145 149-TyrLeuTyrArgAsnAspArgProPheSer-158 166-ValHisGlyGluAsnTyrGluThrThrGlyGluTyrArgVal-179 182-GlnProAspGlySerVal-187 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgLysGluSerAsnArgIleAlaSer AspSerArgAsnSerValPheTyrGlnAsnMetArgGluLeuMetProArgGlyMetLysAlaAsnSer-263 267-GlyTyrAspAlaAspGlyLeuProGlnLys-276 280-SerPheAspAsnGlyLysLysArgGlnSerPheGluTyrTyrLeuLysAsnGlyAsn-298 309-LeuLysAlaAspGlyValThr-315 329-LeuAspGlyGlyArgIleValArgGluGluLysGlnGlyAspArgLeuProAspPhe-347 352-GluAsnLeuGluLysGluValArgArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArgArgAspLeu SerHis-377 Hydrophilic Regions - Hopp-Woods 38-ThrAlaThrGluValProLysAsnPro-46 57-PheArgAsnAlaAspArgAla-63 69-GluSerIleArgThrGluGluAsnLeu-77 80-ThrValAspAspGlyProLeuGlnSerGluLysAspTyr-92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyLys-118 136-LeuSerGlnArgSerProGlu-142 151-TyrArgAsnAspArgProPhe-157 169-GluAsnTyrGluThrThrGlyGluTyr-177 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgLysGluSerAsnArgIleAlaSer AspSerArgAsn-244 250-AsnMetArgGluLeuMetProArgGlyMetLys-260 268-TyrAspAlaAspGlyLeuPro-274 282-AspAsnGlyLysLysArgGlnSer-289 309-LeuLysAlaAspGlyValThr-315 331-GlyGlyArgIleValArgGluGluLysGlnGlyAspArgLeuPro-345 352-GluAsnLeuGluLysGluValArgArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArgArgAspLeu SerHis-377 a729 AMPHI Regions - AMPHI 21-CysThrMetIleProGlnTyr-27 33-GluValAlaGluThrPheLysAsnAspThr-42 55-HisAspTyrPheAla-59 61-ProArgLeuGlnLysLeuIleAspIle-69 149-GlnGlyTyrPheAla-153 164-SerLeuIleAlaThrValAlaLys-171 242-LeuAlaThrLeuIleAsn-247 268-LysLeuProAlaGlyLeu-273 322-LeuGlyGlyLeuPheLysSer-328 371-ValGlnSerAlaPheGlnAspValAlaAsnAla-381 388-LeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArg-400 419-GlyAlaLeuAspLeuLeuAspAla-426 442-LeuThrArgAlaGluAsnLeuAlaAspLeuTyrLysAlaLeuGlyGlyGlyLeuLys-460 Antigenic Index - Jameson-Wolf 25-ProGlnTyrGluGlnProLysValGluVal-34 36-GluThrPheLysAsnAspThrAlaAspSerGlyIleArgAlaValAsp-51 53-GlyTrpHisAspTyrPheAlaAspProArgLeuGlnLys-65 70-AlaLeuGluArgAsnThrSerLeuArgThr-79 85-GlulleTyrArgLysGlnTyrMetIleGluArgAsnAsnLeuLeuPro-100 105-AsnAlaAsnAspSerArgGlnGlySerLeuSerGlyGlyAsnValSerSerSerTyrLysVal-125 138-GlyArgValArgSerSerSerGluAlaAla-147 155-ThrAlaAsnArgAspAlaAla-161 173 -TyrPheAsnGluArgTyrAlaGluGluAlaMet-183 188-ArgValLeuLysThrArgGluGluThrTyrLysLeuSerGluLeuArgTyr-204 215-ArgGlnGlnGluAlaLeuIleGluSerAlaLysAlaAspTyr-228 232-AlaArgSerArgGluGlnAlaArgAsn-240 248-GlnProIleProAspAspLeuProAla-256 277-ValLeuLeuAspArgProAspIleArgAlaAlaGluHisAlaLeuLysGlnAlaAsnAla-296 310-ArgLeuThrGlySerValAspThrHisSerAlaGlu-321 325-LeuPheLysSerGlyThr-330 347-GlyThrAsnLysAlaAsnLeuAspValAlaLysLeuArgGlnGln-361 383-ThrAlaArgGluGlnLeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArgAlaSerLysGluAlaLeu Arg-407 411-LeuArgTyrLysHisGlyValSer-418 424-LeuAspAlaGluArgSerSerTyrSerAla-433 442-LeuThrArgAlaGluAsnLeu-448 455-LeuGlyGlyGlyLeuLysArgAspThrGlnThr spLys-467 Hydrophilic Regions - Hopp-Woods 28-GluGlnProLysValGluVal-34 36-GluThrPheLysAsnAspThrAlaAspSerGlyIleArgAlaVal-50 61-ProArgLeuGlnLys-65 70-AlaLeuGluArgAsnThrSerLeu-77 91-TyrMetIleGluArgAsnAsn-97 105-AsnAlaAsnAspSerArgGlnGlySer-113 138-GlyArgValArgSerSerSerGluAlaAla-147 156-AlaAsnArgAspAlaAla-161 177-ArgTyrAlaGluGluAlaMet-183 188-ArgValLeuLysThrArgGluGluThrTyrLysLeuSerGluLeuArgTyr-204 215-ArgGlnGlnGluAlaLeuIleGluSerAlaLysAlaAspTyr-228 232-AlaArgSerArgGluGlnAlaArgAsn-240 250-IleProAspAspLeuPro-255 277-ValLeuLeuAspArgProAspIleArgAlaAlaGluHisAlaLeuLysGlnAlaAsn-295 315-ValAspThrHisSerAlaGlu-321 350-LysAlaAsnLeuAspValAlaLysLeuArgGln-360 383-ThrAlaArgGluGlnLeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArgAlaSerLysGluAlaLeu Arg-407 424-LeuAspAlaGluArgSerSerTyrSerAla-433 442-LeuThrArgAlaGluAsnLeu-448 458-GlyLeuLysArgAspThrGlnThrAspLys-467 a730 AMPHI Regions - AMPHI 6-ArgLeuIleLysLeuLeuAlaAlaCys-14 26-LeuAlaAlaAspLeu-30 67-GlnIleAsnValIleGlnAspTyrThrHisArg-77 lll-AsnHisAlaAlaAsp-115 141-HisProAlaAspAlaTyrAspGlyProLysGlyGlyAsnTyrProLysProThr-158 187-GlnArgIleSerAspAsnTyrSerAsnLeuGlySerAsnPheSerAspArgAlaAspGlu-206 214-HisAsnAlaLysLeu-218 220-ArgTrpGlyAsnSerMetGluPheIleAsnGlyValAla-232 234-GlyAlaLeuAsnProPheIleSer-241 262-AlaAlaMetArgAsnIleAla-268 277-AlaValIleGlyGlyLeuGlySerValAlaGlyPheGluLysAsnThrArgGluAlaValAspArgTrpIle GlnGlu-302 305-AsnAlaAlaGluThrValGluAlaLeuValAsnValLeuProPheAlaLysValLysAsnLeuThrLysAla AlaLysPro-331 347-ArgThrThrArgLysVa1Thr-353 355-GluThrGluGlyLeuAsnArgIleArgGln-364 384-IleAsnValLeuSerGlyAsnSerIleGlnHis-394 426-ThrHisGluIleSerAspIleValThr-434 475-GluProAlaThrGlyLysValValThrAlaPheProAsp-487 Antigenic Index - Jameson-Wolf 2-LysProLeuArgArgLeuIle-8 35-PheIleThrAspAsnAlaGlnArgGlnHisTyrGluProGlyGlyLys-50 55-GlyAspProArgGlySerValSerAspArgThrGlyGlnIle-68 74-TyrThrHisArgMetGly-79 97-ArgPheSerGlyHisGlyTyrGluGluHisAlaProPheAsp-110 112-HisAlaAlaAspSerAlaSerGluGluLysGlyAsnValAspGluGlyPhe-128 133-LeuAsnTrpGluGlyHisGluHisHisProAlaAspAlaTyrAspGlyProLysGlyGlyAsnTyrProLys ProThrGlyAlaArgAspGluTyrThrTyrHisVal-168 17O-GlyThrAlaArgSerlleLysLeuAsnProThrAspThrArgSerIleArgGlnArglleSerAspAsnTyr SerAsn-195 197-GlySerAsnPheSerAspArgAlaAspGluAlaAsnArgLysMetPheGluHisAsnAlaLysLeuAspArg TrpGlyAsnSer-224 257-TyrAlaIleAspLysAlaAlaMet-264 271-ProAlaGluGlyLys-275 287-GlyPheGluLysAsnThrArgGluAlaValAsp-297 299-TrpIleGlnGluAsnProAsnAlaAlaGluThrValGlu-311 323-LysAsnLeuThrLysAlaAlaLysProGlyLysAlaAlaValSerGlyAspPhe-340 344-TyrAsnThrArgThrThrArgLysValThrThrGluThrGluGlyLeuAsnArgIleArgGlnAsnGlnLys AsnSerAsnIleHisGluLysAsnTyrGlyArgAspAsnProAsnHisIle-384 397-TyrGlyAspGluAlaGlyGlyGly-404 407-PheProGlyLysProGlyLysThrThrPhePro-417 419-HisTrpSerAlaSerLysIleThrHisGluIleSerAsp-431 433-ValThrSerProLysThrGln-439 450-TyrIleAlaLysGlyArgProAlaArg-458 461-SerTyrGluThrArgAspGlyIleArgIle-470 472-ThrValTyrGluProAlaThrGlyLys-480 485-PheProAspArgThrSerAsnProLysTyrAsnProValLys-498 Hydrophilic Regions - Hopp-Woods 2-LysProLeuArgArgLeuIle-8 39-AsnAlaGlnArgGlnHisTyrGluProGlyGly-49 55-GlyAspProArgGlySerValSerAspArgThrGly-66 102-GlyTyrGluGluHisAlaPro-108 112-HisAlaAlaAspSerAlaSerGluGluLysGlyAsnValAspGluGly-127 135-TrpGluGlyHisGluHisHisPro-142 144-AspAlaTyrAspGlyProLysGlyGlyAsnTyrProLys-156 158-ThrGlyAlaArgAspGluTyr-164 170-GlyThrAlaArgSerIleLys-176 178-AsnProThrAspThrArgSerIleArgGlnArgIleSerAsp-191 200-PheSerAspArgAlaAspGluAlaAsnArgLysMetPheGluHisAsnAlaLysLeuAspArgTrpGlyAsn -223 257-TyrAlaIleAspLysAlaAlaMet-264 271-ProAlaGluGlyLys-275 287-GlyPheGluLysAsnThrArgGluAlaValAsp-297 303 -AsnProAsnAlaAlaGluThrValGlu-311 323-LysAsnLeuThrLysAlaAlaLysProGlyLysAlaAlaVal-336 347-ArgThrThrArgLysValThrThrGluThrGluGlyLeuAsnArgIleArgGlnAsnGlnLysAsnSerAsn IleHisGluLysAsnTyrGlyArgAspAsnProAsn-382 399-AspGluAlaGlyGly-403 424-LysIleThrHisGluIleSerAsp-431 450-TyrIleAlaLysGlyArgProAlaArg-458 463-GluThrArgAspGlyIleArgIle-470 485-PheProAspArgThrSerAsnProLys-493 a731 AMPHI Regions - AMPHI 17-AlaCysAlaValPro-21 Antigenic Index - Jameson-Wolf 22-GluAlaTyrAspAspGlyGlyArgGlyHis-31 34-ProValGlnAsnGlnAlaGlyThrAlaAsp-43 45-ArgAlaPheSerCysGluAsnGly-52 56-HisValArgArgLeuAspGlyGlyArgIleAlaLeuArgLeuAspGlyArgArgAlaValLeuSerSerAspV alAlaAlaSerGlyGluArgTyrThrAla-89 92-GlyLeuPheGlyAsnGlyThrGluTrpHisGlnLysGlyGlyGluAla-107 113-AspAlaTyrGlyAsnSerValGluThrSerCysArgAlaArg-126 Hydrophilic Regions - Hopp-Woods 22-GluAlaTyrAspAspGlyGlyArgGlyHis-31 56-HisValArgArgLeuAspGlyGlyArgIleAlaLeuArgLeuAspGlyArgArgAlaValLeu-76 80-ValAlaAlaSerGlyGluArgTyrThrAla-89 100-TrpHisGlnLysGlyGlyGlu-106 119-ValGluThrSerCysArgAlaArg-126 a732 AMPHI Regions - AMPHI 14-LeuGlyAlaIleSer-18 43-ValGlnSerIleArgThrMetAlaGluValTyrGly-54 66-AspAlaAspLeuPheGluGlyAlaMetLysGlyMetVal-78 95-GluIleLysGluSerThrSerGly-102 115-AspGlyPheValLysValValSerProIleGluAsp-126 155-GluAlaValLysLysMet-160 183 -ValAsnLeuThrArg-187 214-GluArgThrValGluSerValAsnThrAlaAlaLys-225 283-LysAlaValProGluAspTyrValTyr-291 297-SerLeuAlaGlyIleProAlaGluLeu-305 322-SerGluIleValAlaGly-327 400-LeuValGlyHisIleGlyAsn-406 446-ArgArgl1eProAsnProAlaLysAsp-454 459-LysAlaLeuAspLeuValLysSerProGluGlnTrpGlnLysSerLeu-474 Antigenic Index - Jameson-Wolf 30-AlaAlaGluLysAspArgArgAspAsnGluVal-40 59-AsnTyrTyrGlnAspLysProAspAlaAspLeuPhe-70 82-AspProHisSerGluTyrMetAspLysLysGlyTyrAlaGluIleLysGluSerThrSerGlyGluPheGlyG ly-106 lll-IleGlyGlnGluAspGlyPhe-117 122-SerProIleGluAspThrProAlaGluArgAlaGlyValLysSerGlyAspPhe-139 144-AspAsnValSerThrArgGlyMetThr-152 155-GluAlaValLysLysMetArgGlyLysProGlyThrLysIle-168 172-LeuSerArgLysAsnAlaAspLysProIle-181 199-LeuIleGluProAspTyrGlyTyr-206 211-GlnPheGlnGluArgThrValGlu-218 221-AsnThrAlaAlaLysGluLeuValLysGluAsnLysGlyLysProLeuLys-237 242-AspLeuArgAspAspProGlyGlyLeu-250 269-ValSerThrLysGlyArgAspGlyLysAspArgMetVal-281 284-AlaValProGluAspTyrVal-290 293-MetGlyGlyAspSerLeuAla-299 303-AlaGluLeuLysThr-307 316-SerGlySerAlaSerAla-321 330-GlnAspHisLysArgAlaVal-336 340-ThrGlnSerPheGlyLysGlySerVal-348 354-LeuSerAsnGlySer-358 368-TyrThrProAsnAspArgSerIleGln-376 384-ValGluValLysAspLysGluArgIlePheGluSerArgGluAlaAspLeu-400 405-GlyAsnProLeuGlyGlyGluAspValAsnSerGlu-416 421-ProLeuGluLysAspAlaAspLysProAlaValLysGluLysGlyLysLysLysLysAspGluAspLeuSer SerArgArglleProAsnProAlaLysAspAspGlnLeuArgLysAlaLeuAspLeuValLysSerProGluGlnT rpGlnLys-472 477-AlaAlaLysLysProValSerAsnLysAspLysLysAspLysLysAspLysLys-494 Hydrophilic Regions - Hopp-Woods 30-AlaAlaGluLysAspArgArgAspAsnGluVal-40 60-TyrTyrGlnAspLysProAspAlaAspLeuPhe-70 82-AspProHisSerGluTyrMetAspLysLysGlyTyrAlaGluIleLysGluSerThrSerGlyGlu-103 lll-IleGlyGlnGluAspGlyPhe-117 122-SerProIleGluAspThrProAlaGluArgAlaGlyValLysSerGlyAspPhe-139 144-AspAsnValSerThr-148 155-GluAlaValLysLysMetArgGlyLysProGlyThr-166 172-LeuSerArgLysAsnAlaAspLysProIle-181 211-GlnPheGlnGluArgThrValGlu-218 221-AsnThrAlaAlaLysGluLeuValLysGluAsnLysGlyLysProLeuLys-237 242-AspLeuArgAspAspProGly-248 271-ThrLysGlyArgAspGlyLysAspArgMetVal-281 303 -AlaGluLeuLysThr-307 330-GlnAspHisLysArgAlaVal-336 370-ProAsnAspArgSerIleGln-376 384-ValGluValLysAspLysGluArgIlePheGluSerArgGluAlaAspLeu-400 408-LeuGlyGlyGluAspValAsnSer-415 421-ProLeuGluLysAspAlaAspLysProAlaValLysGluLysGlyLysLysLysLysAspGluAspLeuSer SerArgArglleProAsnProAlaLysAspAspGlnLeuArgLysAlaLeuAspLeuValLysSerProGluGlnT rpGln-471 477-AlaAlaLysLysProValSerAsnLysAspLysLysAspLysLysAspLysLys-494 a733 AMPHI Regions - AMPHI 6-ThrLeuSerArgLeuSer-ll 33-TyrGlyGlyTyrProAspThrValTyrGluGly-43 53-LysGlnThrGluLysMetGluLysTyrPheVal-63 92-GlyAlaPheArgGlnPheGluGlu-99 Antigenic Index - Jameson-Wolf 2-MetAsnProLysThrLeuSer-8 22-CysGlyGlyAsnGlyGlnLysSer-29 33-TyrGlyGlyTyrProAspThrValTyrGluGlyLeuLysAsnAspAspThrSerLeuGlyLysGlnThrGluL ysMetGluLysTyrPhe-62 65-AlaGlyAsnLysLysMetAsnAlaAlaProGlyAla-76 84-LeuSerArgSerGlyAspLysGluGlyAlaPheArgGlnPheGluGluGluLysArgLeuPheProGlu-106 115-MetLysThrGlyLysGlyGlyLysArg-123 Hydrophilic Regions - Hopp-Woods 40-ValTyrGluGlyLeuLysAsnAspAspThrSerLeuGlyLysGlnThrGluLysMetGluLysTyrPhe-62 65-AlaGlyAsnLysLysMetAsnAla-72 86-ArgSerGlyAspLysGluGlyAlaPheArgGlnPheGluGluGluLysArgLeuPhePro-105 115-MetLysThrGlyLysGlyGlyLysArg-123 a734 AMPHI Regions - AMPHI 19-ArgAlaAlaAspThrTyr-24 26-TyrLeuAlaValTrpGlnAsnProGlnAsnAlaAsnAspValLeuGlnVal-42 53-GluAlaPheAlaGluLeuGluAlaPheCysLys-63 77-ThrGlyCysArgSerValValSer-84 92-LeuAlaTyrProLysAlaLeuGlyAlaMetArg-102 113-ArgPheThrSerVal-117 119-GlnValAlaLeuAsnGlnCysIleLysLys-128 Antigenic Index - Jameson-Wolf 18-AlaArgAlaAlaAsp-22 31-GlnAsnProGlnAsnAlaAsnAsp-38 43-LysThrThrLysGluAspSerThrLysSerGluAlaPheAlaGlu-57 60-AlaPheCysLysGlyGlnAspThr-67 71-IleAlaGluAspGluProThrGlyCysArgSer-81 101-MetArgValGluAsn-105 125-CysIleLysLysTyrGlyAlaGlnGly-133 145-SerSerTyrTyrGly-149 Hydrophilic Regions - Hopp-Woods 18-AlaArgAlaAlaAsp-22 43-LysThrThrLysGluAspSerThrLysSerGluAlaPheAlaGlu-57 60-AlaPheCysLysGlyGlnAspThr-67 71-IleAlaGluAspGluProThrGlyCys-79 101-MetArgValGluAsn-105 125-CysIleLysLysTyrGlyAla-131 a735 AMPHI Regions - AMPHI 6-LeuLeuAlaAsnAsn-10 12-GlnProIleAlaIleIleAla-18 61-TyrAlaArgGluLeuGlu-66 118-GlyCysIleAspGlyPheGly-124 Antigenic Index - Jameson-Wolf 28-HisHisGlnGlyTyrLysSerAlaPheAlaLysGln-39 41-AlaValIleGluLysMetLysArgAspLysAlaGln-52 60-AsnTyrAlaArgGluLeuGluGlnAlaArgAlaGluAlaLysLysTyrGluValLysAla-79 86-LeuAlaLysLysGlnAlaGluValSerArgLeuLysThrGluAsnLysLysGluIleGluAsn-106 108-LeuThrGlnAspArgLysAsnAlaGlyGlyGlyCysIleAspGlyPheGly-124 135-LeuGlyTyrGlyAsn-139 Hydrophilic Regions - Hopp-Woods 41-AlaValIleGluLysMetLysArgAspLysAlaGln-52 60-AsnTyrAlaArgGluLeuGluGlnAlaArgAlaGluAlaLysLysTyrGluValLysAla-79 86-LeuAlaLysLysGlnAlaGluValSerArgLeuLysThrGluAsnLysLysGluIleGluAsn-106 108-LeuThrGlnAspArgLysAsnAlaGly-116 a736 AMPHI Regions - AMPHI 13-GlyLeuIleGlnSerLeuGlySer-20 50-GlyValLeuSerVal-54 61-GlyLeuPheValGly-65 70-LeuGlnGlyTyrThrGlnLeuSerLysPheLysSerAlaAspIle-84 93 -LeuLeuArgGluLeuGlyProVal-100 120-LeuMetLysThrThrGluGlnLeuGluAlaMetAsnValMet-133 135-ValAsnProValAlaArgValVal-142 144-ProArgPheTrpAlaGlyValPheSerMetPro-154 156-LeuAlaSerIlePheAsnValAlaGlyIlePheGlyAla-168 196-AspValIleAsnGlyLeu-201 230-LeuArgAlaSerThrArgThr-236 Antigenic Index - Jameson-Wolf 37-ValArgProArgLeuSerVal-43 77-SerLysPheLysSer-81 93-LeuLeuArgGluLeuGly-98 109-SerAlaGlyGlyAlaMetThrSer-116 122-LysThrThrGluGlnLeuGlu-128 186-GlnMetGlnAsnAsn-190 224-ProThrSerGluGlyIleLeuArgAlaSerThr-234 Hydrophilic Regions - Hopp-Woods 39-ProArgLeuSerVal-43 77-SerLysPheLysSer-81 93 -LeuLeuArgGluLeuGly-98 122-LysThrThrGluGlnLeuGlu-128 a737 AMPHI Regions - AMPHI 56-AlaAlaLeuAlaArgValGlyGly-63 Antigenic Index - Jameson-WoIf 24-AlaHisHisAspGlyHisGlyAspAspAspHisGlyHis-36 40-GlnHisSerLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAlaLeu-58 60-ArgValGlyGlyLysIleThrAspIleAspLeuGluHisAspAsnGlyArgProHisTyrAspValGluIleV alLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArgVal11eSerSerArgArgAspAsp-108 Hydrophilic Regions - Hopp-Woods 27-AspGlyHisGlyAspAspAspHisGlyHis-36 40-GlnHisSerLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAlaLeu-58 61-ValGlyGlyLysIleThrAspIleAspLeuGluHisAspAsnGlyArgProHisTyr-79 82-GluIleValLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArg-100 102-IleSerSerArgArgAspAsp-108 a738 AMPHI Regions - AMPHI 91-LeuMetAsnLeuIleTyrProGlyMetAsnAsp-101 139-IleGlySerLeuLeuGlnSerCysIle-147 228-ThrTyrIleAlaAlaIleAlaLeuIle-236 271-ThrIleLeuGluThrPheThrGlyIle-279 285-ValGluArgValAlaAsnGlyGlyPheThrAspLeuProArgGlnIle-300 306-LeuAlaAlaPheGlnSer-311 316-GlyHisGlyTrpAsnSerPheAla-323 338-AspAsnLeuLeuSerAsnLeuPheThr-346 371-LeuLeuThrGlylleAlaGlyLeuLeuLysArg-381 398-MetCysHisSerMetLeu-403 461-ArgMetValAsnAlaPheSerPro-468 472-AspSerAlaLysThrLeuAsnArgLys-480 482-AsnGluLeuArgTyrIleSer-488 507-LeuProGluTyrProGluThr-513 549-AlaLysGlnTrpMetArgAlaThr-556 567-TyrAlaAspGluIleArgLysLeuProVal-576 579-ProLeuLeuProGluLeuLeuLysAspCysLysAlaPheAlaAlaAlaPro-595 Antigenic Index - Jameson-Wolf 38-LeuGlnProSerProAspPheTyrHis-46 62-AlaGlyLysLysLeuPheAsp-68 123-HisTyrGlyGlnGluArgIle-129 154-GlyTrpGluAspThrProLeu-160 177-GlyGlnArgAsnAsnLeuGly-183 196-LeuAsnGlyGlnArgLysIleProPro-204 242-PheArgSerAspLysSerAsnArgArgThrIle-252 283-ThrAlaValGluArgValAlaAsnGlyGlyPheThrAspLeuProArgGlnIleGluTrpArgLys-304 316-GlyHisGlyTrpAsnSerPheAla-323 332-GluGlnHisAsnIleHisAspAsnLeuLeu-341 378-LeuLeuLysArgProLeuThr-384 424-ProAlaGluAlaSerAspGlyIleAlaPheLysLysAlaAla-437 468-ProAlaThr spAspSerAlaLysThrLeuAsnArgLys11eAsnGlu-483 508-ProGluTyrProGluThrGlnThrTrpAlaGlu-518 520-AlaThrLeuLysSerLeuLysTyrArgProHisSerAla-532 542-ArgGlnGlyLysValAlaGluAlaLysGlnTrpMet-553 555-AlaThrGlnSerTyr-559 566-ArgTyrAlaAspGlulleArgLys-573 584-LeuLeuLysAspCysLysAla-590 595-ProGlyHisProGluAlaLysProCysLys-604 Hydrophilic Regions - Hopp-Woods 62-AlaGlyLysLysLeuPheAsp-68 125-GlyGlnGluArgIle-129 198-GlyGlnArgLysIlePro-203 243-ArgSerAspLysSerAsnArgArgThrIle-252 283-ThrAlaValGluArgValAla-289 300-11eGluTrpArgLys-304 332-GluGlnHisAsnIle-336 378-LeuLeuLysArgProLeuThr-384 425-AlaGluAlaSerAsp-429 431-IleAlaPheLysLysAlaAla-437 469-AlaThrAspAspSerAlaLysThrLeuAsnArgLysIleAsnGlu-483 525-LeuLysTyrArgPro-529 542-ArgGlnGlyLysValAlaGluAlaLysGlnTrpMet-553 566-ArgTyrAlaAspGluIleArgLys-573 584-LeuLeuLysAspCysLysAla-590 596-GlyHisProGluAlaLysProCysLys-604 a739 AMPHI Regions - AMPHI 6-AsnLysProPheArgLeu-11 53-HisThrAspSerPro-57 86-ProAlaGlnProAspGlyThrAsp-93 120-ThrAspArgGlnProAspAspAlaGlyAla-129 131-AlaGluAsnThrLeu-135 Antigenic Index - Jameson-Wolf l-MetAlaLysLysProAsnLysProPheArgLeuThrPro-13 39-PheAsnProAsnGlyAspLysThrLeuGlnThrGluProGlnHisThrAspSerProArgGluThrGluPhe- 62 64-LeuProAsnGlyValValGlyGlnAspAlaAlaGlnProGluHisHisHisAlaSerSerSerAlaProAlaG lnProAspGlyThrAspGluSerGlySerGlyLeuProSerProAlaAlaProLysLysAsnArgValLysProGl nProAlaAspThrAlaGlnThrAspArgGlnProAspAspAlaGlyAlaGlnAlaGluAsnThrLeuLysGluThr ProValLeuProThrAsnValProArgProGluProArgLysGluThrProGluLysGlnAlaGlnProLysGluT hrProLysGluLysGluThrProLysGluAsnHisThrLysProAspThrProLysAsnThrProProLysProHi sLysGluIleLeu-193 Hydrophilic Regions - Hopp-Woods 1-MetAlaLysLysProAsnLysProPheArgLeu-ll 41-ProAsnGlyAspLysThrLeuGlnThrGluProGlnHisThrAspSerProArgGluThrGlu-61 72-AspAlaAlaGlnProGluHisHisHis-80 87-AlaGlnProAspGlyThrAspGluSerGlySer-97 103-AlaAlaProLysLysAsnArgValLysProGlnProAlaAspThrAlaGlnThrAspArgGlnProAspAsp AlaGlyAlaGlnAlaGluAsnThrLeuLysGluThrPro-139 145-ValProArgProGluProArgLysGluThrProGluLysGlnAlaGlnProLysGluThrProLysGluLys GluThrProLysGluAsnHisThrLysProAspThrProLysAsnThrProProLysProHisLysGluIleLeu- 193 a740 Antigenic Index - Jameson-Wolf 25-AlaAsnProProGluAspLysProGln-33 57-IleLysHisHisLeuLysGlnGluPheAspLeuLysArgGlnThr-71 Hydrophilic Regions - Hopp-Woods 27-ProProGluAspLysProGln-33 57-IleLysHisHisLeuLysGlnGluPheAspLeuLysArgGlnThr-71 a741 AMPHI Regions - AMPHI 30-AspIleGlyAlaValLeuAlaAspAlaLeuThrAla-41 93-SerArgPheAspPheIleArgGlnIleGlu-102 158-ThrSerPheAspLysLeuProGluGlyGlyArg-168 200-IleGluHisLeuLys-204 251-GlnGluValAlaGlySerAlaGlu-258 Antigenic Index - Jameson-Wolf 21-SerSerGlyGlyGly-25 43-LeuAspHisLysAspLysSerLeu-50 56-AspGlnSerValArgLysAsnGluLysLeuLysLeu-67 71-GlyAlaGluLysThrTyrGlyAsnGlyAspSerLeuAsnThrGlyLysLeuLysAsnAspLysValSerArgP heAspPhe-97 101-HeGluValAspGlyGlnLeu-107 117-ValTyrLysGlnSerHisSerAla-124 129-GlnThrGluGlnValGlnAspSerGluHisSerGlyLysMetValAlaLysArgGlnPheArgIleGlyAsp IleAlaGlyGluHisThrSerPheAspLysLeuProGluGlyGlyArgAlaThrTyrArg-172 174-ThrAlaPheGlySerAspAspAlaSerGlyLysLeu-185 191-PheAlaAlaLysGlnGlyHisGlyLysIleGluHisLeuLysSerProGluLeuAsnVal-210 213-AlaAlaSerAspIleLysProAspLysLysArgHisAla-225 234-AsnGlnAlaGluLysGlySerTyrSer-242 247-GlyGlyGlnAlaGlnGluValAlaGly-255 257-AlaGluValGluThrAlaAsnGly-264 Hydrophilic Regions - Hopp-Woods 43-LeuAspHisLysAspLysSerLeu-50 57-GlnSerValArgLysAsnGluLysLeuLysLeu-67 71-GlyAlaGluLysThrTyrGlyAsn-78 85-GlyLysLeuLysAsnAspLysValSerArg-94 lOl-IleGluValAspGly-105 132-GlnValGlnAspSerGluHisSerGly-140 142-MetValAlaLysArgGlnPheArgIle-150 152-AspIleAlaGlyGlu-156 158-ThrSerPheAspLysLeuProGluGlyGlyArgAlaThrTyr-171 177-GlySerAspAspAlaSerGly-183 195-GlnGlyHisGlyLysIleGluHisLeuLysSerProGluLeuAsnVal-210 213-AlaAlaSerAspIleLysProAspLysLysArgHisAla-225 235-GlnAlaGluLysGlySer-240 249-GlnAlaGlnGluValAlaGly-255 257-AlaGluValGluThr-261 a742 AMPHI Regions - AMPHI 26-ArgGluValProAsp-30 53-AsnArgProLeuGln-57 66-GluAspTrpSerArgLeu-71 77-AsnLeuPheSerGlyPheLysHisValPheAsp-87 143-LysAlaLeuGluLysLeuLysAla-150 153-AspGluThrAlaLysGluTyrArg-160 234-AsnAlaAlaGlnArgPheProAsnSerLeuTyrAsp-245 326-ValTyrAlaGlySer-330 340-SerSerProLeuVal-344 369-ArgAsnAlaLysLysIle-374 422-ThrProAlaPheThrGlyPheSerGlyThrValProValTrpLysThrValLys-439 448-LeuTyrAsnTyrAlaLysTyrLeuAsnThrAsn-458 475-LeuHisLeuLeuGlyGlyLeuHisTyr-483 505-PheGlnThrAlaSerSer-510 543-IleTyrGlySerTyrThrLysIlePheLysGlnGlnAspAsn-556 616-GlySerPheGlnThrValAlaLysProlleGlyLysValValSerArg-631 643-GluAspTrpLysValPheAlaGly-650 657-ArgTyrLysAsnAla-661 670-AlaLysAsnThrGly-674 677-ProTyrAsnPheSerAsnPheThrProValHisIle-688 714-ThrSerSerLeuTyrAsnIle-720 725-TyrGlyLeuIleAspGlyPheValArgTyr-734 736-LeuGlyLysHisAlaLysLeu-742 759-TyrAsnArgThrArgGlyAlaAsnAsnPheTyrGlyGluPro-772 Antigenic Index - Jameson-Wolf 6-AlaGluAlaAspAlaGlyAsp-12 21-MetTyrGlnLysSerArgGluValProAspPheSerGly-33 37-SerCysGluAsnGlnLysThrAlaProPheSerSerThrProAlaCysAsnArgProLeuGlnLeuProArgA snThrTyrLeuGlyGluAspTrpSerArgLeuSerAlaAspLysTyrAsn-77 86-PheAspAsnGlyTrp-90 97-SerTyrThrLysAsnGluSerAspAlaLysVal-107 120-LeuSerAspGluAspAla-125 130-ThrGluLysAsnGluValIleProPheGluProLysAspLysAlaLeuGluLysLeuLysAlaTyrArgAsp GluThrAlaLysGluTyrArgGluArgLysAspAspPheValLysAsnArgPheAspAsnThrAla-175 177-GluGlnTyrArgSerArgArgAlaAlaGluArgLysAlaGlyPheAspGluCysMet-195 205-CysGlnGlySerTrpGlyAspProGlyValAspAlaAspLysSerGluPheValAsp-223 235-AlaAlaGlnArgPheProAsnSerLeuTyrAspSerSerPheAsnArgLysAlaThrAlaAsnArgArgTyr SerTyrMetPro-262 264-ArgHisThrLysAspAspArgGlnTrp-272 286-GlyArgGluHisAsp-290 295-TyrAlaTyrGlyAspGluLysIleArgSerGluTyr-306 308-GlulleTyrGluArgArgHisArgValArgProAsnThrGlyAla-322 331-CysGlnGlyGluProAspGlyAspLeuSer-340 345-ArgGlyHisLysGluProAspTrpGlnAlaTyrAspGluLysGlyAsnArgThrValTyrAlaGluGluCys ArgAsnAlaLysLysIleLysThrGluProLysLeuAspAlaGluGlyLysGln-386 389-TyrTyrAspGluTyrSerGlySerArgThr-398 405-TyrGluLeuAspGluLysGlyAsnLysIleGlnGluThrAsnProAspGlyThrPro-423 439-LysValAlaAspAspHisVal-445 454-TyrLeuAsnThrAsnLysThrHis-461 485-ArgTyrGluThrSerGlnThrLysAspMetProValArgTyrGlyGlnProAlaSerAspPheGlnThr-50 7 509-SerSerIleLysAlaAspGlnAspHisTyrThr-519 521-LysMetGlnGlyHisLysLeuThrPro-529 545-GlySerTyrThrLys-549 551-PheLysGlnGlnAspAsnValAspValSerAla-561 584-GlyArgLeuAsnAla-588 595-LeuGluGlnLysAsnArgThrValVal-603 610-GlyAlaGlyGlyLysGlnGlySer-617 628-ValValSerArgGlyAlaGluPheGluLeuSerGlyGluLeuAsnGluAspTrpLys-646 652-ThrTyrAsnLysSerArgTyrLysAsnAlaAlaGluValAsnAlaGluArgLeuAlaLysAsnThrGlyAla AspProTyrAsnPheSerAsn-682 708-ValSerAlaGlnSerGlyThrSerSerLeuTyrAsnIleArgGlnGlyGly-724 735-GluLeuGlyLysHisAlaLys-741 746-GlyThrAsnLeuAsnGlyArgThrTyrPheGluAsnAsnTyrAsnArgThrArgGlyAlaAsnAsnPheTyr GlyGluProArgThrValSerMet-777 Hydrophilic Regions - Hopp-Woods 6-AlaGluAlaAspAlaGlyAsp-12 23-GlnLysSerArgGluValProAsp-30 67-AspTrpSerArgLeuSerAlaAspLys-75 97-SerTyrThrLysAsnGluSerAspAlaLysVal-107 120-LeuSerAspGluAspAla-125 130-ThrGluLysAsnGluValIleProPheGluProLysAspLysAlaLeuGluLysLeuLysAlaTyrArgAsp GluThrAlaLysGluTyrArgGluArgLysAspAspPheValLysAsnArgPheAspAsnThrAla-175 177-GluGlnTyrArgSerArgArgAlaAlaGluArgLysAlaGlyPheAspGluCysMet-195 212-ProGlyValAspAlaAspLysSerGluPheValAsp-223 247-SerPheAsnArgLysAlaThrAlaAsnArgArgTyrSer-259 264-ArgHisThrLysAspAspArgGlnTrp-272 286-GlyArgGluHisAsp-290 297-TyrGlyAspGluLysIleArgSerGluTyr-306 308-GluIleTyrGluArgArgHisArgValArgProAsnThr-320 331-CysGlnGlyGluProAspGlyAspLeu-339 345-ArgGlyHisLysGluProAsp-351 354-AlaTyrAspGluLysGlyAsnArg-361 363-ValTyrAlaGluGluCysArgAsnAlaLysLysIleLysThrGluProLysLeuAspAlaGluGlyLysGln -386 393-TyrSerGlySerArg-397 405-TyrGluLeuAspGluLysGlyAsnLysIleGlnGluThrAsnProAspGly-421 439-LysValAlaAspAspHisVal-445 485-ArgTyrGluThrSerGlnThrLysAspMetProVal-496 500-GlnProAlaSerAsp-504 509-SerSerIleLysAlaAspGlnAspHisTyrThr-519 551-PheLysGlnGlnAspAsnValAspValSerAla-561 597-GlnLysAsnArgThrValVal-603 611-AlaGlyGlyLysGlnGlySer-617 628-ValValSerArgGlyAlaGluPheGluLeuSerGlyGluLeuAsnGluAspTrpLys-646 654-AsnLysSerArgTyrLysAsnAlaAlaGluValAsnAlaGluArgLeuAlaLys-671 735-GluLeuGlyLysHisAlaLys-741 758-AsnTyrAsnArgThrArgGly-764 770-GlyGluProArgThrValSerMet-777 a743 AMPHI Regions - AMPHI 19-TyrGlyGlySerPhe-23 58-SerTyrThrIleAsp-62 64-MetSerThrAlaThrGly-69 96-ThrLeuGluGluAlaMetLysAsnThrThrGlyValAsnValValArgAsp-112 158-ValTyrAspHisIleGluValValArgGlyAlaThrGly-170 Antigenic Index - Jameson-Wolf l-MetAsnGlnAsnHis-5 30-ValSerAspGlyAsnThrVal-36 41-ValAsnValArgGlySerHisAlaLeuSerGlyLysThrGluLysThrArgSerTyrThrIleAspArgMetS erThr-66 72-IleAlaGlyLysAspThrProGlnSer-80 85-ThrArgSerArgLeuAspAspLysAlaValHisThrLeuGluGluAlaMetLysAsnThrThrGly-106 109-ValValArgAspSerGlyLeuGlnThrArgPheLeuSerArgGlyPhe-124 128-GlnIleGlyGluAspGlyIle-134 140-GlyArgSerGlyTyrThrAlaLysIleAspValSerProSerThrAsp-155 163-GluValValArgGlyAlaThrGlyLeuThrGlnSerAsnSerGluProGlyGly-180 184-LeuIleArgLysArg-188 Hydrophilic Regions - Hopp-Woods 49-LeuSerGlyLysThrGluLysThrArgSerTyrThrIleAspArgMetSerThr-66 72-IleAlaGlyLysAspThrProGln-79 85-ThrArgSerArgLeuAspAspLysAlaValHisThrLeuGluGluAlaMetLysAsn-103 109-ValValArgAspSerGlyLeu-115 128-GlnIleGlyGluAspGlyIle-134 174-SerAsnSerGluProGlyGly-180 184-LeuIleArgLysArg-188 a746 AMPHI Regions - AMPHI 10-LeuSerGlyTyrGluGlnLeuLys-17 42-LeuSerSerGlyProAlaGluGlnThrAla-51 72-SerAlaAlaAspLysProGlnAsp-79 94-SerGluProGluAsn-98 118-LeuGluAlaSerGluLysLeuGlnGlnAlaGluThrAlaLysThrAlaPro-134 153-AspThrValAlaValGlu-158 160-ProLysArgThrAlaGluThr-166 170-LysAlaGluArgThr-174 184-ThrLysThrAlaGluLysValAlaAspLysProLys-195 210-SerAlaValLysGluAlaLysLysAlaAspLysAlaGluSer-223 238-GluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLys-254 287-SerThrIleThrGluIleMetThr-294 307-TyrLysAsnAlaArgAspAlaGluArgAspLeu-317 Antigenic Index - Jameson-Wolf 1-MetSerGluAsnLysGlnAsnGluValLeuSerGlyTyrGluGlnLeuLysArgArgAsnArgArgArgLeuVa lThr-26 43-SerSerGlyProAlaGluGlnThrAlaGlyGluThrSerGlyValGluAsnLysAlaAlaGly-63 72-SerAlaAlaAspLysProGlnAspLeuAlaGlyGluAspLysProSerAlaAlaAspSerGluIleSerGluP roGluAsnVal-99 107-AsnAspArgLeuGluAspSerAsnIleLysGlyLeuGluAlaSerGluLysLeuGlnGlnAlaGluThrAla LysThrAlaProLysGlnAlaLysGlnArgAlaAlaGluLysValProAlaThrAlaAspSerThrAspThrValA laValGluLysProLysArgThrAlaGluThrLysProGlnLysAlaGluArgThrAlaLysAlaLysProLysAl aLysGluThrLysThrAlaGluLysValAlaAspLysProLysThrAlaAlaGluLysThrLysProAspThrAla LysSerAspSerAlaValLysGluAlaLysLysAlaAspLysAlaGluSerLysLysThrAlaGluLysAspArgS erAspGlyLysLysHisGluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLysGluLysSe rGlyLysLysAlaAla-262 266-GlyTyrAlaGluLysGluArgAlaLeuSerLeuGlnArgLysMetLysAlaAlaGlyIle-285 292-IleMetThrAspAsnGlyLysValTyrArgValLysSerSerAsnTyrLysAsnAlaArgAspAlaGluArg AspLeuAsnLysLeuArgVal-322 Hydrophilic Regions - Hopp-Woods l-MetSerGluAsnLysGlnAsnGluVal-9 14-GluGlnLeuLysArgArgAsnArgArgArgLeuVal-25 45-GlyProAlaGluGlnThrAlaGlyGluThrSerGlyValGluAsnLysAlaAlaGly-63 72-SerAlaAlaAspLysProGlnAspLeuAlaGlyGluAspLysProSerAlaAlaAspSerGluIleSerGluP roGluAsnVal-99 108-AspArgLeuGluAspSerAsnIleLysGlyLeuGluAlaSerGluLysLeuGlnGlnAlaGluThrAlaLys ThrAlaProLysGlnAlaLysGlnArgAlaAlaGluLysValProAlaThrAlaAspSerThrAsp-153 155-ValAlaValGluLysProLysArgThrAlaGluThrLysProGlnLysAlaGluArgThrAlaLysAlaLys ProLysAlaLysGluThrLysThrAlaGluLysValAlaAspLysProLysThrAlaAlaGluLysThrLysProA ΞpThrAlaLysSerAspSerAlaValLysGluAlaLysLysAlaAspLysAlaGluSerLysLysThrAlaGluLy sAspArgSerAspGlyLysLysHisGluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLys GluLysSerGlyLysLysAlaAla-262 267-TyrAlaGluLysGluArgAlaLeuSerLeuGlnArgLysMetLysAlaAlaGlyIle-285 292-IleMetThrAspAsnGlyLysValTyrArgValLysSerSerAsnTyrLysAsnAlaArgAspAlaGluArg AspLeuAsnLysLeuArgVal-322 a747 AMPHI Regions - AMPHI 28-ValSerLysSerAlaLysGlyTrp-35 Antigenic Index - Jameson-Wolf 8-TyrAlaAspLeuArgGlyLysThrLysVal-17 23-CysAlaSerArgAspValSerLysSerAlaLysGlyTrp-35 42-AsnValGlyLysGlnLeuThrAspSerValGlyLeuGluPheAspProTyrTyrArgHisLysThrIleCysL ysProArgGluIleValLeuAspGlyAspLysThrLysMetGlyArgSerLysSerAsnGluTyrGly-88 97-SerGlnLeuLysSerLys-102 Hydrophilic Regions - Hopp-Woods 8-TyrAlaAspLeuArgGlyLysThrLysVal-17 23-CysAlaSerArgAspValSerLysSerAlaLys-33 63-ThrIleCysLysProArgGluIleValLeuAspGlyAspLysThrLysMetGlyArgSerLysSerAsnGluT yr-87 a748 AMPHI Regions - AMPHI 22-GlyAlaValGlyAlaIleGlyGly-29 40-AlaGluArgThrAlaGluSerGlnHis-48 82-SerAlaLysGlnLeuGluAsnLeuPheArgThrLeu-93 155-LeuGlnGluMetArgAspPheSerAsnAspLysLeuGlnLysSerTrp-170 188-GlnAlaAlaLeuArgAspIleIleLysHisThrValGln-200 250-GlyValAlaAlaAsnSer-255 257-AspGluProGluTrp-261 268-GlnAlaValArgLeuIleArgHisPheValGluPheTrpAspArg-282 310-GlnProAspPheAlaLys-315 334-ArgAspProGluPheLeu-339 390-LeuGluGluTyrIleSerProPhe-397 Antigenic Index - Jameson-Wolf l-MetSerLysAsnGlnProAlaGlnProThrArgArgThrLeuPhe-15 29-GlyTyrLeuGlyGlyLysLysArgGlyGluThrAlaGluArgThrAlaGluSerGlnHisSerProGlnAla- 52 80-AlaGlnSerAlaLysGlnLeuGluAsn-88 101-ThrGlnGlyGlyGluTyrGlnAspGlyAspAspLysLeuProProAlaGlySerGly-119 125-PheAsnProAspGlyLeuThr-131 139-SerLeuPheAspGlyArgPheGlyLeuLysAspLysLysProIleHis-154 156-GlnGluMetArgAspPheSerAsnAspLysLeuGlnLysSerTrpCysAspGlyAspLeuSer-176 183-ThrProGluThrCys-187 208-IleAspGlyTrpGlnProLysSerGluProGlyAlaMetAla-221 226-LeuGlyPheArgAspGlyThrGlyAsnProLysValSerAspProLysThrAlaAspGlu-245 255-SerLeuAspGluProGluTrpAlaLysAsnGlySerTyrGlnAla-269 279-PheTrpAspArgThrProLeuGlnGluGlnThrAspIlePheGlyArgArgLysTyrSerGlyAlaProMet AspGlyLysLysGluAlaAspGlnProAspPheAlaLysAspProGluGlyAsnThrThrProLysAspSerHisI leArgLeuAlaAsnProArgAspProGluPheLeuLysLysHisArgLeuPheArg-346 348-AlaTyrSerTyrSerArgGlyLeuAlaSerSerGlyGlnLeu-361 385-LeuAsnGlyGluProLeuGluGluTyr-393 406-ProGlyValGluLysGlyGlyPhe-413 Hydrophilic Regions - Hopp-Woods l-MetSerLysAsnGlnPro-6 8-GlnProThrArgArgThrLeuPhe-15 32-GlyGlyLysLysArgGlyGluThrAlaGluArgThrAlaGluSerGlnHis-48 80-AlaGlnSerAlaLysGlnLeuGluAsn-88 104-GlyGluTyrGlnAspGlyAspAspLysLeuProPro-115 145-PheGlyLeuLysAspLysLysProIleHis-154 156-GlnGluMetArgAspPheSerAsnAspLysLeuGlnLysSerTrpCysAspGlyAspLeu-175 211-TrpGlnProLysSerGluProGlyAlaMetAla-221 229-ArgAspGlyThrGlyAsnProLysValSerAspProLysThrAlaAsp-244 255-SerLeuAspGluProGluTrpAlaLys-263 283-ThrProLeuGlnGluGlnThrAspIlePheGlyArgArgLysTyrSer-298 301-ProMetAspGlyLysLysGluAlaAspGlnProAspPheAlaLysAspProGluGlyAsnThrThrProLys AspSerHisIle-328 331-AlaAsnProArgAspProGluPheLeuLysLysHisArgLeuPheArg-346 388-GluProLeuGluGluTyr-393 407-GlyValGluLysGlyGly-412 a749 AMPHI Regions - AMPHI 1-MetArgLysPheAsnLeuThrAlaLeuSerValMetLeuAlaLeuGlyLeuThrAlaCysGlnProProGluAl aGluLysAlaAlaProAlaAlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySerValSerlleAlaValAsn AspAsnAlaCysGluProMetGluLeuThrValProSerGlyGlnValValPheAsnlleLysAsnAsnSerGlyA rgLysLeuGluTrpGluIleLeuLysGlyValMetValValAspGluArgGluAsnlleAlaProGlyLeuSerAs pLysMetThrValThrLeuLeuProGlyGluTyrGluMetThrCysGlyLeuLeuThrAsnProArgGlyLysLeu ValValThrAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuSerGlnProLeuAlaAspT yrLysAlaTyrValGlnGlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGl yAspIleGluLysAlaLysSerLeuPheAlaAspThrArgValHisTyrGluArglleGluProIleAlaGluLeu PheSerGluLeuAspProVallleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGlyPheThrG lyPheHisArglleGluTyrAlaLeuTrpValGluLysAspValSerGlyValLysGluIleAlaAlaLysLeuMe tThrAspValGluAlaLeuGlnLysGluIleAspAlaLeuAlaPheProProGlyLysValValGlyGlyAlaSer GluLeuIleGluGluValAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSerAspP heGlnAlaAsnValAspGlySerLysLysIleValAspLeuPheArgProLeuIleGluThrLysAsnLysAlaLe uLeuGluLysThrAspThrAsnPheLysGlnValAsnGluIleLeuAlaLysTyrArgThrLysAspGlyPheGlu ThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeuGlnAlaSerlleAsnAlaLeuAlaGluAspLeuAlaG InLeuArgGlyl1eLeuGlyLeuLys-388 Antigenic Index - Jameson-Wolf 1-MetArgLysPheAsnLeuThrAlaLeuSerValMetLeuAlaLeuGlyLeuThrAlaCysGlnProProGluAl aGluLysAlaAlaProAlaAlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySerValSerlleAlaValAsn AspAsnAlaCysGluProMetGluLeuThrValProSerGlyGlnValValPheAsnlleLysAsnAsnSerGlyA rgLysLeuGluTrpGluIleLeuLysGlyValMetValValAspGluArgGluAsnlleAlaProGlyLeuSerAs pLysMetThrValThrLeuLeuProGlyGluTyrGluMetThrCysGlyLeuLeuThrAsnProArgGlyLysLeu ValValThrAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuSerGlnProLeuAlaAspT yrLysAlaTyrValGlnGlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGl yAspIleGluLysAlaLysSerLeuPheAlaAspThrArgValHisTyrGluArglleGluProIleAlaGluLeu PheSerGluLeuAspProVallleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGlyPheThrG lyPheHisArglleGluTyrAlaLeuTrpValGluLysAspValSerGlyValLysGluIleAlaAlaLysLeuMe tThrAspValGluAlaLeuGlnLysGluIleAspAlaLeuAlaPheProProGlyLysValValGlyGlyAlaSer GluLeuIleGluGluValAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSerAspP heGlnAlaAsnValAspGlySerLysLysIleValAspLeuPheArgProLeuIleGluThrLysAsnLysAlaLe uLeuGluLysThrAspThrAsnPheLysGlnValAsnGluIleLeuAlaLysTyrArgThrLysAspGlyPheGlu ThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeuGlnAlaSerlleAsnAlaLeuAlaGluAspLeuAlaG InLeuArgGlylleLeuGlyLeuLys-388 Hydrophilic Regions - Hopp-Woods 1-MetArgLysPheAsnLeuThrAlaLeuSerValMetLeuAlaLeuGlyLeuThrAlaCysGlnProProGluAl aGluLysAlaAlaProAlaAlaSerGlyGluAlaGlnThrAlaAsnGluGlyGlySerValSerlleAlaValAsn AspAsnAlaCysGluProMetGluLeuThrValProSerGlyGlnValValPheAsnlleLysAsnAsnSerGlyA rgLysLeuGluTrpGluIleLeuLysGlyValMetValValAspGluArgGluAsnlleAlaProGlyLeuSerAs pLysMetThrValThrLeuLeuProGlyGluTyrGluMetThrCysGlyLeuLeuThrAsnProArgGlyLysLeu ValValThrAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuSerGlnProLeuAlaAεpT yrLysAlaTyrValGlnGlyGluValLysGluLeuValAlaLysThrLysThrPheThrGluAlaValLysAlaGl yAspIleGluLysAlaLysSerLeuPheAlaAspThrArgValHisTyrGluArglleGluProIleAlaGluLeu PheSerGluLeuAspProVallleAspAlaArgGluAspAspPheLysAspGlyAlaLysAspAlaGlyPheThrG lyPheHisArglleGluTyrAlaLeuTrpValGluLysAspValSerGlyValLysGluIleAlaAlaLysLeuMe tThrAspValGluAlaLeuGlnLysGluIleAspAlaLeuAlaPheProProGlyLysValValGlyGlyAlaSer GluLeuIleGluGluValAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSerAspP heGlnAlaAsnValAspGlySerLysLysIleValAspLeuPheArgProLeuIleGluThrLysAsnLysAlaLe uLeuGluLysThrAspThrAsnPheLysGlnValAsnGluIleLeuAlaLysTyrArgThrLysAspGlyPheGlu ThrTyrAspLysLeuGlyGluAlaAspArgLysAlaLeuGlnAlaSerlleAsnAlaLeuAlaGluAspLeuAlaG lnLeuArgGlyIleLeuGlyLeuLys-388 a750 AMPHI Regions - AMPHI 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuLeuThrAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerAlaSerAlaAlaThrLeuThrValProThrAlaArgGlyAspAlaValValProLys AsnProGluArgValAlaValTyrAεpTrpAlaAlaLeuAspThrLeuThrGluLeuGlyValAsnValGlyAlaT hrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLysAlaAlaThrValGlyThrLeuPheGluPr oAspTyrGluAlaLeuHisArgTyrAsnProGlnLeuVallleThrGlyGlyProGlyAlaGluAlaTyrGluGln LeuAlaLysAsnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyGluLysGlnMetG luThrLeuAlaArgllePheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnlleAspAlaLeuPheAlaGl nThrArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysValSerAlaPheGly ThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluG lyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProAspTrpIlePhellelleAspArgThrAl aAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValArgGlyThrAsnAlaTrpLys ArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlySerArgGlnLeuIleGlnAlaAlaG luGlnLeuLysGluAlaPheGluLysAlaGluProValAlaAlaGlyLysGlu-321 Antigenic Index - Jameson-Wolf 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuLeuThrAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerAlaSerAlaAlaThrLeuThrValProThrAlaArgGlyAspAlaValValProLys AsnProGluArgValAlaValTyrAspTrpAlaAlaLeuAspThrLeuThrGluLeuGlyValAsnValGlyAlaT hrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLysAlaAlaThrValGlyThrLeuPheGluPr oAspTyrGluAlaLeuHisArgTyrAsnProGlnLeuVallleThrGlyGlyProGlyAlaGluAlaTyrGluGln LeuAlaLysAsnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyGluLysGlnMetG luThrLeuAlaArgllePheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnlleAspAlaLeuPheAlaGl nThrArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysValSerAlaPheGly ThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluG lyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProAspTrpIlePhellelleAspArgThrAl aAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValArgGlyThrAsnAlaTrpLys ArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlySerArgGlnLeuIleGlnAlaAlaG luGlnLeuLysGluAlaPheGluLysAlaGluProValAlaAlaGlyLysGlu-321 Hydrophilic Regions - Hopp-Woods 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuLeuThrAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerAlaSerAlaAlaThrLeuThrValProThrAlaArgGlyAspAlaValValProLys AsnProGluArgValAlaValTyrAspTrpAlaAlaLeuAspThrLeuThrGluLeuGlyValAsnValGlyAlaT hrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLysAlaAlaThrValGlyThrLeuPheGluPr oAspTyrGluAlaLeuHisArgTyrAsnProGlnLeuVallleThrGlyGlyProGlyAlaGluAlaTyrGluGln LeuAlaLysAsnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyGluLysGlnMetG luThrLeuAlaArgllePheGlyLysGluAlaArgAlaAlaGluLeuLysAlaGlnlleAspAlaLeuPheAlaGl nThrArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysValSerAlaPheGly ThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluG lyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProAspTrpIlePhellelleAspArgThrAl aAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValArgGlyThrAsnAlaTrpLys ArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlySerArgGlnLeuIleGlnAlaAlaG luGlnLeuLysGluAlaPheGluLysAlaGluProValAlaAlaGlyLysGlu-321 a756 AMPHI Regions - AMPHI 1-MetThrAlaAsnPheAlaGlnThrLeuValGluIleGlnAspSerLeuXxxArgValValSerThrValGlnTy rGlyAεpAspAsnLeuLysArgLeuThrAlaAspLysArgLysGlnTyrGluLeuAsnPheLysIleSerGluGly SerThrArgValGluSerAspPheLysGluThrLeuValArgPheGlyArgAspMetLeuGlnAspMetProProL ysIleArgSerAlaThrLeuValAlaLeuThrThrLeuLeuValGlyGlyAlaLeuGlyTyrGlyTyrLeuGluTy rLeuLysGlnValAlaSerGluGlyTyrGlnThrGluArgLeuTyrAsnAlaValAspArgLeuAlaGluSerGln GluArglleThrSerAlalleLeuLysGlyAlaArgGlyAlaAspPheValGlnlleGlyArgArgSerTyrSerA rgGluAspIleSerGluAlaAsnArgArgAlaGluArgValProTyrGlyAlaGluLeuValSerAspGlyAsnPh eThrAlaValLeuSerAspIleGlyAsp-186 Antigenic Index - Jameson-Wolf 1-MetThrAlaAsnPheAlaGlnThrLeuValGluIleGlnAspSerLeuXxxArgValValSerThrValGlnTy rGlyAspAspAsnLeuLysArgLeuThrAlaAspLysArgLysGlnTyrGluLeuAsnPheLysIleSerGluGly SerThrArgValGluSerAspPheLysGluThrLeuValArgPheGlyArgAspMetLeuGlnAspMetProProL ysIleArgSerAlaThrLeuValAlaLeuThrThrLeuLeuValGlyGlyAlaLeuGlyTyrGlyTyrLeuGluTy rLeuLysGlnValAlaSerGluGlyTyrGlnThrGluArgLeuTyrAsnAlaValAspArgLeuAlaGluSerGln GluArglleThrSerAlalleLeuLysGlyAlaArgGlyAlaAspPheValGlnlleGlyArgArgSerTyrSerA rgGluAspIleSerGluAlaAsnArgArgAlaGluArgValProTyrGlyAlaGluLeuValSerAspGlyAsnPh eThrAlaValLeuSerAspIleGlyAsp-186 Hydrophilic Regions - Hopp-Woods 1-MetThrAlaAsnPheAlaGlnThrLeuValGluIleGlnAspSerLeuXxxArgValValSerThrValGlnTy rGlyAspAspAsnLeuLysArgLeuThrAlaAspLysArgLysGlnTyrGluLeuAsnPheLysIleSerGluGly SerThrArgValGluSerAspPheLysGluThrLeuValArgPheGlyArgAspMetLeuGlnAspMetProProL ysIleArgSerAlaThrLeuValAlaLeuThrThrLeuLeuValGlyGlyAlaLeuGlyTyrGlyTyrLeuGluTy rLeuLysGlnValAlaSerGluGlyTyrGlnThrGluArgLeuTyrAsnAlaValAspArgLeuAlaGluSerGln GluArglleThrSerAlalleLeuLysGlyAlaArgGlyAlaAspPheValGlnlleGlyArgArgSerTyrSerA rgGluAspIleSerGluAlaAsnArgArgAlaGluArgValProTyrGlyAlaGluLeuValSerAspGlyAsnPh eThrAlaValLeuSerAspIleGlyAsp-186 a758 AMPHI Regions - AMPHI 1-MetAsnAsnLeuThrValPheThrArgPheAspThrAspLeuAlaThrLeuAlaAspGluLeuGlnTyrValTr pGluHisThrAlaValThrAspHiεGlnGlyLysLeuValGluIleProValCysTyrGlyGlyGluTyrGlyPro AspLeuAlaGluValAlaAlaPheHisGlnThrVallleSerGluIleValArgArgHisThrAlaGlnThrTyrT hrValPheMetMetGlyPheGlnProGlyPheProTyrLeuGlyGlyLeuProGluAlaLeuHiεThrProArgAr gAlaValProArgThrSerValProAlaGlySerValGlylleGlyGlySerGlnThrGlyValTyrProPheAla SerProGlyGlyTrpGlnllelleGlyArgThrGluLeuProLeuPheArgAlaAspLeuAsnProProThrLeuL euAlaAlaGlyAspGlnValArgPheValAlaGluArgIleGluPro-167 Antigenic Index - Jameson-Wolf 1-MetAsnAsnLeuThrValPheThrArgPheAspThrAspLeuAlaThrLeuAlaAspGluLeuGlnTyrValTr pGluHisThrAlaValThrAspHiεGlnGlyLysLeuValGluIleProValCysTyrGlyGlyGluTyrGlyPro AspLeuAlaGluValAlaAlaPheHisGlnThrVallleSerGluIleValArgArgHisThrAlaGlnThrTyrT hrValPheMetMetGlyPheGlnProGlyPheProTyrLeuGlyGlyLeuProGluAlaLeuHisThrProArgAr gAlaValProArgThrSerValProAlaGlySerValGlylleGlyGlySerGlnThrGlyValTyrProPheAla SerProGlyGlyTrpGlnllelleGlyArgThrGluLeuProLeuPheArgAlaAspLeuAsnProProThrLeuL euAlaAlaGlyAspGlnValArgPheValAlaGluArgIleGluPro-167 Hydrophilic Regions - Hopp-Woods 1-MetAsnAsnLeuThrValPheThrArgPheAspThrAspLeuAlaThrLeuAlaAspGluLeuGlnTyrValTr pGluHisThrAlaValThrAspHisGlnGlyLysLeuValGluIleProValCysTyrGlyGlyGluTyrGlyPro AspLeuAlaGluValAlaAlaPheHisGlnThrVallleSerGluIleValArgArgHisThrAlaGlnThrTyrT hrValPheMetMetGlyPheGlnProGlyPheProTyrLeuGlyGlyLeuProGluAlaLeuHisThrProArgAr gAlaValProArgThrSerValProAlaGlySerValGlylleGlyGlySerGlnThrGlyValTyrProPheAla SerProGlyGlyTrpGlnllelleGlyArgThrGluLeuProLeuPheArgAlaAspLeuAsnProProThrLeuL euAlaAlaGlyAspGlnValArgPheValAlaGluArgIleGluPro-167 a761 AMPHI Regions - AMPHI 1-MetLysIleSerPheHisLeuAlaLeuLeuProThrLeuIleIleAlaSerPheProValAlaAlaAlaAspTh rGlnAspAsnGlyGluHisTyrThrAlaThrLeuProThrValSerValValGlyGlnSerAεpThrSerValLeu LysGlyTyrlleAsnTyrAspGluAlaAlaValThrArgAsnGlyGlnLeuIleLysGluThrProGlnThrlleA spThrLeuAsnlleGlnLysAsnLysAsnTyrGlyThrAsnAspLeuSerSerlleLeuGluGlyAsnAlaGlyll eAspAlaAlaTyrAspMetArgGlyGluSerllePheLeuArgGlyPheGlnAlaAspAlaSerAspIleTyrArg AspGlyValArgGluSerGlyGlnValArgArgSerThrAlaAsnlleGluArgValGluIleLeuLysGlyProS erSerValLeuTyrGlyArgThrAsnGlyGlyGlyVallleAsnMetValSerLysTyrAlaAsnPheLysGlnSe rArgAsnlleGlyThrValTyrGlySerTrpAlaAsnArgSerLeuAsnMetAspIleAsnGluValLeuAsnLys AsnValAlalleArgLeuThrGlyGluValGlyArgAlaAsnSerPheArgSerGlylleAspSerLysAsnValM etValSerProSerlleThrValLysLeuAspAsnGlyLeuLysTrpThrGlyGlnTyrThrTyrAspAsnValGl uArgThrProAspArgSerProThrLysSerValTyrAspArgPheGlyLeuProTyrArgMetGlyPheAlaHis ArgAsnAspPheValLysAspLysLeuGlnValTrpArgSerAspLeuGluTyrAlaPheAsnAspLyεTrpArgA laGlnTrpGlnLeuAlaHisArgThrAlaAlaGlnAspPheAspHisPheTyrAlaGlySerGluAsnGlyAsnLe uIleLysArgAsnTyrAlaTrpGlnGlnThrAspAsnLysThrLeuSerSerAsnLeuThrLeuAsnGlyAspTyr ThrlleGlyArgPheGluAsnHisLeuThrValGlyMetAspTyrSerArgGluHisArgAsnProThrLeuGlyP heSerSerAlaPheSerAlaSerlleAsnProTyrAspArgAlaSerTrpProAlaSerGlyArgLeuGlnProIl eLeuThrGlnAsnArgHisLysAlaAspSerTyrGlyllePheValGlnAsnllePheSerAlaThrProAspLeu LysPheValLeuGlyGlyArgTyrAspLysTyrThrPheAsnSerGluAsnLysLeuThrGlySerSerArgGlnT yrSerGlyHisSerPheSerProAsnlleGlyAlaValTrpAsnlleAsnProValHisThrLeuTyrAlaSerTy rAsnLysGlyPheAlaProTyrGlyGlyArgGlyGlyTyrLeuSerlleAspThrLeuSerSerAlaValPheAsn AlaAspProGluTyrThrArgGlnTyrGluThrGlyValLysSerSerTrpLeuAspAspArgLeuSerThrThrL euSerAlaTyrGlnlleGluArgPheAsnlleArgTyrArgProAspProLysAsnAsnProTyrlleTyrAlaVa lSerGlyLysHisArgSerArgGlyValGluLeuSerAlalleGlyGlnllelleProLysLysLeuTyrLeuArg GlySerLeuGlyValMetGlnAlaLysValValGluAspLysGluAsnProAspArgValGlylleHisLeuAsnA snThrSerAsnValThrGlyAsnLeuPhePheArgTyrThrProThrGluAsnLeuTyrGlyGluIleGlyValTh rGlyThrGlyLysArgTyrGlyTyrAspSerArgAsnLysGluValThrThrLeuProGlyPheAlaArgValAsp AlaMetLeuGlyTrpAsnHisLysAsnValAsnValThrPheAlaAlaAlaAsnLeuPheAsnGlnLysTyrTrpA rgSerAspSerMetProGlyAsnProArgGlyTyrThrAlaArgValAsnTyrArgPhe-703 Antigenic Index - Jameson-Wolf 1-MetLysIleSerPheHisLeuAlaLeuLeuProThrLeuIleIleAlaSerPheProValAlaAlaAlaAspTh rGlnAspAsnGlyGluHisTyrThrAlaThrLeuProThrValSerValValGlyGlnSerAspThrSerValLeu LysGlyTyrlleAsnTyrAspGluAlaAlaValThrArgAsnGlyGlnLeuIleLysGluThrProGlnThrlleA spThrLeuAsnlleGlnLysAsnLysAsnTyrGlyThrAsnAspLeuSerSerlleLeuGluGlyAsnAlaGlyll eAspAlaAlaTyrAspMetArgGlyGluSerllePheLeuArgGlyPheGlnAlaAspAlaSerAspIleTyrArg AspGlyValArgGluSerGlyGlnValArgArgSerThrAlaAsnlleGluArgValGluIleLeuLysGlyProS erSerValLeuTyrGlyArgThrAsnGlyGlyGlyVallleAsnMetValSerLysTyrAlaAsnPheLysGlnSe rArgAsnlleGlyThrValTyrGlySerTrpAlaAsnArgSerLeuAsnMetAspIleAsnGluValLeuAsnLys AsnValAlalleArgLeuThrGlyGluValGlyArgAlaAsnSerPheArgSerGlylleAspSerLysAsnValM etValSerProSerlleThrValLysLeuAspAsnGlyLeuLysTrpThrGlyGlnTyrThrTyrAspAsnValGl uArgThrProAspArgSerProThrLysSerValTyrAspArgPheGlyLeuProTyrArgMetGlyPheAlaHis ArgAsnAspPheValLysAspLysLeuGlnValTrpArgSerAεpLeuGluTyrAlaPheAεnAspLysTrpArgA laGlnTrpGlnLeuAlaHisArgThrAlaAlaGlnAspPheAspHisPheTyrAlaGlySerGluAsnGlyAsnLe uIleLysArgAsnTyrAlaTrpGlnGlnThrAspAsnLysThrLeuSerSerAsnLeuThrLeuAsnGlyAspTyr ThrlleGlyArgPheGluAsnHisLeuThrValGlyMetAspTyrSerArgGluHisArgAsnProThrLeuGlyP heSerSerAlaPheSerAlaSerlleAsnProTyrAspArgAlaSerTrpProAlaSerGlyArgLeuGlnProIl eLeuThrGlnAsnArgHisLysAlaAspSerTyrGlyllePheValGlnAsnllePheSerAlaThrProAspLeu LysPheValLeuGlyGlyArgTyrAspLysTyrThrPheAsnSerGluAsnLyεLeuThrGlySerSerArgGlnT yrSerGlyHisSerPheSerProAsnlleGlyAlaValTrpAsnlleAsnProValHisThrLeuTyrAlaSerTy rAsnLysGlyPheAlaProTyrGlyGlyArgGlyGlyTyrLeuSerlleAspThrLeuSerSerAlaValPheAsn AlaAspProGluTyrThrArgGlnTyrGluThrGlyValLysSerSerTrpLeuAspAspArgLeuSerThrThrL euSerAlaTyrGlnlleGluArgPheAsnlleArgTyrArgProAspProLysAsnAsnProTyrlleTyrAlaVa lSerGlyLysHisArgSerArgGlyValGluLeuSerAlalleGlyGlnllelleProLysLysLeuTyrLeuArg GlySerLeuGlyValMetGlnAlaLysValValGluAεpLysGluAsnProAspArgValGlylleHisLeuAsnA snThrSerAsnValThrGlyAsnLeuPhePheArgTyrThrProThrGluAsnLeuTyrGlyGluIleGlyValTh rGlyThrGlyLysArgTyrGlyTyrAspSerArgAsnLysGluValThrThrLeuProGlyPheAlaArgValAsp AlaMetLeuGlyTrpAsnHisLysAsnValAsnValThrPheAlaAlaAlaAsnLeuPheAsnGlnLysTyrTrpA rgSerAspSerMetProGlyAsnProArgGlyTyrThrAlaArgValAsnTyrArgPhe-703 Hydrophilic Regions - Hopp-Woods 1-MetLysIleSerPheHisLeuAlaLeuLeuProThrLeuIleIleAlaSerPheProValAlaAlaAlaAspTh rGlnAspAsnGlyGluHisTyrThrAlaThrLeuProThrValSerValValGlyGlnSerAspThrSerValLeu LysGlyTyrlleAsnTyrAspGluAlaAlaValThrArgAsnGlyGlnLeuIleLysGluThrProGlnThrlleA spThrLeuAsnlleGlnLysAsnLysAsnTyrGlyThrAsnAspLeuSerSerlleLeuGluGlyAεnAlaGlyll eAspAlaAlaTyrAspMetArgGlyGluSerllePheLeuArgGlyPheGlnAlaAspAlaSerAspIleTyrArg AspGlyValArgGluSerGlyGlnValArgArgSerThrAlaAsnlleGluArgValGluIleLeuLysGlyProS erSerValLeuTyrGlyArgThrAsnGlyGlyGlyVallleAsnMetValSerLysTyrAlaAsnPheLysGlnSe rArgAsnlleGlyThrValTyrGlySerTrpAlaAsnArgSerLeuAsnMetAspIleAsnGluValLeuAεnLys AsnValAlalleArgLeuThrGlyGluValGlyArgAlaAsnSerPheArgSerGlylleAspSerLysAsnValM etValSerProSerlleThrValLysLeuAspAsnGlyLeuLysTrpThrGlyGlnTyrThrTyrAspAsnValGl uArgThrProAspArgSerProThrLysSerValTyrAspArgPheGlyLeuProTyrArgMetGlyPheAlaHis ArgAsnAspPheValLyεAspLysLeuGlnValTrpArgSerAspLeuGluTyrAlaPheAsnAspLysTrpArgA laGlnTrpGlnLeuAlaHisArgThrAlaAlaGlnAspPheAspHisPheTyrAlaGlySerGluAsnGlyAsnLe uIleLysArgAsnTyrAlaTrpGlnGlnThrAspAsnLysThrLeuSerSerAsnLeuThrLeuAsnGlyAspTyr ThrlleGlyArgPheGluAsnHisLeuThrValGlyMetAspTyrSerArgGluHisArgAsnProThrLeuGlyP heSerSerAlaPheSerAlaSerlleAsnProTyrAεpArgAlaSerTrpProAlaSerGlyArgLeuGlnProIl eLeuThrGlnAsnArgHisLysAlaAspSerTyrGlyllePheValGlnAsnllePheSerAlaThrProAspLeu LysPheValLeuGlyGlyArgTyrAspLysTyrThrPheAsnSerGluAsnLysLeuThrGlySerSerArgGlnT yrSerGlyHisSerPheSerProAsnlleGlyAlaValTrpAsnlleAsnProValHisThrLeuTyrAlaSerTy rAsnLysGlyPheAlaProTyrGlyGlyArgGlyGlyTyrLeuSerlleAspThrLeuSerSerAlaValPheAsn AlaAspProGluTyrThrArgGlnTyrGluThrGlyValLysSerSerTrpLeuAspAspArgLeuSerThrThrL euSerAlaTyrGlnlleGluArgPheAsnlleArgTyr rgProAspProLysAsnAsnProTyrlleTyrAlaVa lSerGlyLysHisArgSerArgGlyValGluLeuSerAlalleGlyGlnllelleProLysLysLeuTyrLeuArg GlySerLeuGlyValMetGlnAlaLysValValGluAspLysGluAsnProAspArgValGlylleHisLeuAsnA snThrSerAsnValThrGlyAsnLeuPhePheArgTyrThrProThrGluAsnLeuTyrGlyGluIleGlyValTh rGlyThrGlyLysArgTyrGlyTyrAspSerArgAsnLysGluValThrThrLeuProGlyPheAlaArgValAsp AlaMetLeuGlyTrpAsnHisLysAsnValAsnValThrPheAlaAlaAlaAsnLeuPheAsnGlnLysTyrTrpA rgSerAspSerMetProGlyAsnProArgGlyTyrThrAlaArgValAsnTyrArgPhe-703 a762 AMPHI Regions - AMPHI 1-MetLysTrpLeuLeuAsnMetIleMetArgProIleLysPheSerMetValAsnThrLeuLeuPheIleValIl eCysSerSerPhePheAspLeuLeuValGlnLeuCysThrlleLeuPheHisSerGlnLysIleTyrPhelleThr LeuPheLeuLeuPhellePheAsnPheValThrLysSerlleTyrMetAlallelleTyrProIleLeuTyrPheP heThrlleLysLysTyrTyrProTyrSerArgLysValllelleLeuLeuSerLeuAlaLeuSerlleTyrPheSe rPheMetAspPheTyrPhePheSerlleTyrSerAspAsnLeuSerTyrGluThrGluProLeuHisLeuTyrlle ProIleIleIleAsnPhePheSerLeuLeuValSerAsnPheIleLeuSerPheIleAsnLys-147 Antigenic Index - Jameson-Wolf 1-MetLysTrpLeuLeuAsnMetIleMetArgProIleLysPheSerMetValAsnThrLeuLeuPheIleValIl eCysSerSerPhePheAspLeuLeuValGlnLeuCysThrlleLeuPheHisSerGlnLysIleTyrPhelleThr LeuPheLeuLeuPhellePheAsnPheValThrLysSerlleTyrMetAlallelleTyrProIleLeuTyrPheP heThrlleLysLysTyrTyrProTyrSerArgLysValllelleLeuLeuSerLeuAlaLeuSerlleTyrPheSe rPheMetAspPheTyrPhePheSerlleTyrSerAspAsnLeuSerTyrGluThrGluProLeuHisLeuTyrlle ProIleIleIleAsnPhePheSerLeuLeuValSerAεnPheIleLeuSerPheIleAsnLys-147 Hydrophilic Regions - Hopp-Woods 1-MetLysTrpLeuLeuAsnMetIleMetArgProIleLysPheSerMetValAsnThrLeuLeuPheIleValIl eCysSerSerPhePheAspLeuLeuValGlnLeuCysThrlleLeuPheHisSerGlnLysIleTyrPhelleThr LeuPheLeuLeuPhellePheAsnPheValThrLysSerlleTyrMetAlallelleTyrProIleLeuTyrPheP heThrlleLysLysTyrTyrProTyrSerArgLysValllelleLeuLeuSerLeuAlaLeuSerlleTyrPheSe rPheMetAspPheTyrPhePheSerlleTyrSerAspAsnLeuSerTyrGluThrGluProLeuHisLeuTyrlle ProIleIleIleAsnPhePheSerLeuLeuValSerAsnPheIleLeuSerPheIleAsnLys-147 a763 AMPHI Regions - AMPHI 1-MetThrLeuLeuAsnLeuMetIleMetGlnAspTyrGlyIleSerValCysLeuThrLeuThrProTyrLeuGl nHisGluLeuPheSerAlaMetLysSerTyrPheSerLysTyrlleLeuProValSerLeuPheThrLeuProLeu SerLeuSerProSerValSerAlaPheThrLeuProGluAlaTrpArgAlaAlaGlnGlnHisSerAlaAspPheG lnAlaSerHisTyrGlnArgAspAlaValArgAlaArgGlnGlnGlnAlaLysAlaAlaPheLeuProHisValSe rAlaAsnAlaSerTyrGlnArgGlnProProSerlleSerSerThrArgGluThrGlnGlyTrpSerValGlnVal GlyGlnThrLeuPheAspAlaAlaLysPheAlaGlnTyrArgGlnSerArgPheAspThrGlnAlaAlaGluGlnA rgPheAspAlaAlaArgGluGluLeuLeuLeuLysValAlaGluSerTyrPheAsnValLeuLeuSerArgAspTh rValAlaAlaHisAlaAlaGluLysGluAlaTyrAlaGlnGlnValArgGlnAlaGlnAlaLeuPheAsnLysGly AlaAlaThrAlaLeuAspIleHisGluAlaLysAlaGlyTyrAspAsnAlaLeuAlaGlnGluIleAlaValLeuA laGluLysGlnThrTyrGluAsnGlnLeuAsnAspTyrThrGlyLeuAspSerLysGlnlleGluAlalleAspTh rAlaAsnLeuLeuAlaArgTyrLeuProLysLeuGluArgTyrSerLeuAspGluTrpGlnArglleAlaLeuSer AsnAsnHisGluTyrArgMetGlnGlnLeuAlaLeuGlnSerSerGlyGlnAlaLeuArgAlaAlaGlnAsnSerA rgTyrProThrValSerAlaHisValGlyTyrGlnAsnAεnLeuTyrThrSerSerAlaGlnAεnAsnAspTyrHi sTyrArgGlyLysGlyMetSerValGlyValGlnLeuAsnLeuProLeuTyrThrGlyGlyGluLeuSerGlyLys IleHisGluAlaGluAlaGlnTyrGlyAlaAlaGluAlaGlnLeuThrAlaThrGluArgHisIleLysLeuAlaV alArgGlnAlaTyrThrGluSerGlyAlaAlaArgTyrGlnlleMetAlaGlnGluArgValLeuGluSerSerAr gLeuLysLeuLysSerThrGluThrGlyGlnGlnTyrGlylleArgAsnArgLeuGluVallleArgAlaArgGln GluValAlaGlnAlaGluGlnLysLeuAlaGlnAlaArgTyrLysPheMetLeuAlaTyrLeuArgLeuValLysG luSerGlyLeuGlyLeuGluThrValPheAlaGlu-467 Antigenic Index - Jameson-Wolf 1-MetThrLeuLeuAsnLeuMetIleMetGlnAspTyrGlyIleSerValCysLeuThrLeuThrProTyrLeuGl nHisGluLeuPheSerAlaMetLysSerTyrPheSerLysTyrlleLeuProValSerLeuPheThrLeuProLeu SerLeuSerProSerValSerAlaPheThrLeuProGluAlaTrpArgAlaAlaGlnGlnHisSerAlaAspPheG InAlaSerHisTyrGlnArgAspAlaValArgAlaArgGlnGlnGlnAlaLysAlaAlaPheLeuProHisValSe rAlaAsnAlaSerTyrGlnArgGlnProProSerlleSerSerThrArgGluThrGlnGlyTrpSerValGlnVal GlyGlnThrLeuPheAspAlaAlaLysPheAlaGlnTyrArgGlnSerArgPheAspThrGlnAlaAlaGluGlnA rgPheAspAlaAlaArgGluGluLeuLeuLeuLysValAlaGluSerTyrPheAsnValLeuLeuSerArgAspTh rValAlaAlaHisAlaAlaGluLysGluAlaTyrAlaGlnGlnValArgGlnAlaGlnAlaLeuPheAsnLysGly AlaAlaThrAlaLeuAspIleHisGluAlaLysAlaGlyTyrAspAsnAlaLeuAlaGlnGluIleAlaValLeuA laGluLysGlnThrTyrGluAsnGlnLeuAsnAspTyrThrGlyLeuAspSerLysGlnlleGluAlalleAspTh rAlaAsnLeuLeuAlaArgTyrLeuProLysLeuGluArgTyrSerLeuAspGluTrpGlnArglleAlaLeuSer AsnAsnHisGluTyrArgMetGlnGlnLeuAlaLeuGlnSerSerGlyGlnAlaLeuArgAlaAlaGlnAsnSerA rgTyrProThrValSerAlaHisValGlyTyrGlnAsnAsnLeuTyrThrSerSerAlaGlnAsnAsnAspTyrHi ΞTyrArgGlyLysGlyMetSerValGlyValGlnLeuAsnLeuProLeuTyrThrGlyGlyGluLeuSerGlyLys IleHisGluAlaGluAlaGlnTyrGlyAlaAlaGluAlaGlnLeuThrAlaThrGluArgHisIleLysLeuAlaV alArgGlnAlaTyrThrGluSerGlyAlaAlaArgTyrGlnlleMetAlaGlnGluArgValLeuGluSerSerAr gLeuLysLeuLysSerThrGluThrGlyGlnGlnTyrGlylleArgAsnArgLeuGluVallleArgAlaArgGln GluValAlaGlnAlaGluGlnLysLeuAlaGlnAlaArgTyrLysPheMetLeuAlaTyrLeuArgLeuValLysG luSerGlyLeuGlyLeuGluThrValPheAlaGlu-467 Hydrophilic Regions - Hopp-Woods 1-MetThrLeuLeuAsnLeuMetIleMetGlnAspTyrGlyIleSerValCysLeuThrLeuThrProTyrLeuGl nHisGluLeuPheSerAlaMetLysSerTyrPheSerLysTyrlleLeuProValSerLeuPheThrLeuProLeu SerLeuSerProSerValSerAlaPheThrLeuProGluAlaTrpArgAlaAlaGlnGlnHisSerAlaAspPheG lnAlaSerHisTyrGlnArgAspAlaValArgAlaArgGlnGlnGlnAlaLysAlaAlaPheLeuProHisValSe rAlaAsnAlaSerTyrGlnArgGlnProProSerlleSerSerThrArgGluThrGlnGlyTrpSerValGlnVal GlyGlnThrLeuPheAspAlaAlaLysPheAlaGlnTyrArgGlnSerArgPheAspThrGlnAlaAlaGluGlnA rgPheAspAlaAlaArgGluGluLeuLeuLeuLysValAlaGluSerTyrPheAsnValLeuLeuSerArgAspTh rValAlaAlaHisAlaAlaGluLysGluAlaTyrAlaGlnGlnValArgGlnAlaGlnAlaLeuPheAsnLysGly AlaAlaThrAlaLeuAspIleHisGluAlaLysAlaGlyTyrAspAsnAlaLeuAlaGlnGluIleAlaValLeuA laGluLysGlnThrTyrGluAsnGlnLeuAsnAspTyrThrGlyLeuAspSerLysGlnlleGluAlalleAspTh rAlaAsnLeuLeuAlaArgTyrLeuProLysLeuGluArgTyrSerLeuAspGluTrpGlnArglleAlaLeuSer AsnAsnHisGluTyrArgMetGlnGlnLeuAlaLeuGlnSerSerGlyGlnAlaLeuArgAlaAlaGlnAsnSerA rgTyrProThrValSerAlaHisValGlyTyrGlnAsnAsnLeuTyrThrSerSerAlaGlnAsnAsnAspTyrHi sTyrArgGlyLysGlyMetSerValGlyValGlnLeuAsnLeuProLeuTyrThrGlyGlyGluLeuSerGlyLys IleHisGluAlaGluAlaGlnTyrGlyAlaAlaGluAlaGlnLeuThrAlaThrGluArgHisIleLysLeuAlaV alArgGlnAlaTyrThrGluSerGlyAlaAlaArgTyrGlnlleMetAlaGlnGluArgValLeuGluSerSerAr gLeuLysLeuLysSerThrGluThrGlyGlnGlnTyrGlylleArgAεnArgLeuGluVallleArgAlaArgGln GluValAlaGlnAlaGluGlnLysLeuAlaGlnAlaArgTyrLysPheMetLeuAlaTyrLeuArgLeuValLysG luSerGlyLeuGlyLeuGluThrValPheAlaGlu-467 a764 AMPHI Regions - AMPHI 1-MetPhePheSerAlaLeuLysSerPheLeuSerArgTyrIleThrValTrpArgAsnValTrpAlaValArgAs pGlnLeuGluProProLyεArgThrAlaGluGluGlnAlaPheLeuProAlaHisLeuGluLeuThrAspThrPro ValSerAlaAlaProLysTrpAlaAlaArgPhelleMetAlaPheAlaLeuLeuAlaLeuLeuTrpSerTrpPheG lyLysIleAspIleValAlaAlaAlaSerGlyLysThrValSerGlyGlyArgSerLysThrlleGlnProLeuGl uThrValValValLysAlaValHisValArgAspGlyGlnHisValLysGlnGlyGluThrLeuAlaGluLeuGlu AlaValGlyThrAspSerAspValValGlnSerGluGlnAlaLeuGlnAlaAlaGlnLeuSerLysLeuArgTyrG luAlaValLeuAlaAlaLeuGluSerArgThrValProHisIleAspMetAlaGlnAlaArgSerLeuGlyLeuSe rAspAlaAspValGlnSerAlaGlnValLeuAlaGlnHisGlnTyrGlnAlaTrpAlaAlaGlnAspAlaGlnLeu GlnSerAlaLeuArgGlyHisGlnAlaGluLeuGlnSerAlaLysAlaGlnGluGlnLysLeuValSerValGlyA lalleGluGlnGlnLysThrAlaAspTyrArgArgLeuArgAlaAspAsnPhelleSerGluHisAlaPheLeuGl uGlnGlnSerLysSerValSerAsnTrpAsnAspLeuGluSerThrArgGlyGlnMetArgGlnlleGlnAlaAla IleAlaGlnAlaGluGlnAsnArgValLeuAsnThrGlnAsnLeuLysArgAspThrLeuAspAlaLeuArgGlnA laAsnGluGlnlleAspGlnTyrArgGlyGlnThrAspLysAlaLysGlnArgGlnGlnLeuMetThrlleGlnSe rProAlaAspGlyThrValGlnGluLeuAlaThrTyrThrValGlyGlyValValGlnAlaAlaGlnLysMetMet ValValAlaProAspAspAspLysMetAspValGluValLeuValLeuAsnLysAspIleGlyPheValGluGlnG lyGlnAspAlaValValLysIleGluSerPheProTyrThrArgTyrGlyTyrLeuThrGlyLysValLysSerVa lSerHisAspAlaValSerHisGluGlnLeuGlyLeuValTyrThrAlaValValSerLeuAspLysHisThrLeu AsnIleAspGlyLys-435 Antigenic Index - Jameson-Wolf 1-MetPhePheSerAlaLeuLysSerPheLeuSerArgTyrIleThrValTrpArgAsnValTrpAlaValArgAs pGlnLeuGluProProLysArgThrAlaGluGluGlnAlaPheLeuProAlaHisLeuGluLeuThrAspThrPro ValSerAlaAlaProLysTrpAlaAlaArgPhelleMetAlaPheAlaLeuLeuAlaLeuLeuTrpSerTrpPheG lyLysIleAspIleValAlaAlaAlaSerGlyLysThrValSerGlyGlyArgSerLysThrlleGlnProLeuGl uThrValValValLysAlaValHisValArgAspGlyGlnHisValLysGlnGlyGluThrLeuAlaGluLeuGlu AlaValGlyThrAspSerAspValValGlnSerGluGlnAlaLeuGlnAlaAlaGlnLeuSerLysLeuArgTyrG luAlaValLeuAlaAlaLeuGluSerArgThrValProHisIleAspMetAlaGlnAlaArgSerLeuGlyLeuSe rAspAlaAspValGlnSerAlaGlnValLeuAlaGlnHisGlnTyrGlnAlaTrpAlaAlaGlnAspAlaGlnLeu GlnSerAlaLeuArgGlyHisGlnAlaGluLeuGlnSerAlaLysAlaGlnGluGlnLysLeuValSerValGlyA lalleGluGlnGlnLysThrAlaAspTyrArgArgLeuArgAlaAspAsnPhelleSerGluHisAlaPheLeuGl uGlnGlnSerLysSerValSerAsnTrpAsnAspLeuGluSerThrArgGlyGlnMetArgGlnlleGlnAlaAla IleAlaGlnAlaGluGlnAsnArgValLeuAsnThrGlnAsnLeuLysArgAspThrLeuAspAlaLeuArgGlnA laAsnGluGlnlleAspGlnTyrArgGlyGlnThrAspLysAlaLysGlnArgGlnGlnLeuMetThrlleGlnSe rProAlaAspGlyThrValGlnGluLeuAlaThrTyrThrValGlyGlyValValGlnAlaAlaGlnLysMetMet ValValAlaProAspAspAspLysMetAspValGluValLeuValLeuAsnLysAspIleGlyPheValGluGlnG lyGlnAspAlaValValLysIleGluSerPheProTyrThrArgTyrGlyTyrLeuThrGlyLysValLysSerVa lSerHisAspAlaValSerHisGluGlnLeuGlyLeuValTyrThrAlaValValSerLeuAspLysHisThrLeu AsnIleAspGlyLys-435 Hydrophilic Regions - Hopp-Woods 1-MetPhePheSerAlaLeuLysSerPheLeuSerArgTyrIleThrValTrpArgAsnValTrpAlaValArgAs pGlnLeuGluProProLysArgThrAlaGluGluGlnAlaPheLeuProAlaHisLeuGluLeuThrAspThrPro ValSerAlaAlaProLysTrpAlaAlaArgPhelleMetAlaPheAlaLeuLeuAlaLeuLeuTrpSerTrpPheG lyLysIleAspIleValAlaAlaAlaSerGlyLysThrValSerGlyGlyArgSerLysThrlleGlnProLeuGl uThrValValValLysAlaValHisValArgAspGlyGlnHisValLysGlnGlyGluThrLeuAlaGluLeuGlu AlaValGlyThrAspSerAspValValGlnSerGluGlnAlaLeuGlnAlaAlaGlnLeuSerLysLeuArgTyrG luAlaValLeuAlaAlaLeuGluSerArgThrValProHisIleAspMetAlaGlnAlaArgSerLeuGlyLeuSe rAspAlaAspValGlnSerAlaGlnValLeuAlaGlnHisGlnTyrGlnAlaTrpAlaAlaGlnAspAlaGlnLeu GlnSerAlaLeuArgGlyHisGlnAlaGluLeuGlnSerAlaLysAlaGlnGluGlnLysLeuValSerValGlyA lalleGluGlnGlnLysThrAlaAspTyrArgArgLeuArgAlaAspAsnPhelleSerGluHisAlaPheLeuGl uGlnGlnSerLysSerValSerAsnTrpAsnAspLeuGluΞerThrArgGlyGlnMetArgGlnlleGlnAlaAla IleAlaGlnAlaGluGlnAsnArgValLeuAsnThrGlnAsnLeuLysArgAspThrLeuAspAlaLeuArgGlnA laAsnGluGlnlleAspGlnTyrArgGlyGlnThrAspLysAlaLysGlnArgGlnGlnLeuMetThrlleGlnSe rProAlaAspGlyThrValGlnGluLeuAlaThrTyrThrValGlyGlyValValGlnAlaAlaGlnLysMetMet ValValAlaProAspAspAspLysMetAspValGluValLeuValLeuAsnLysAspIleGlyPheValGluGlnG lyGlnAspAlaValValLysIleGluSerPheProTyrThrArgTyrGlyTyrLeuThrGlyLysValLysSerVa lSerHisAspAlaValSerHisGluGlnLeuGlyLeuValTyrThrAlaValValSerLeuAspLysHisThrLeu AsnIleAspGlyLys-435 a765 AMPHI Regions - AMPHI 36-SerAlaIleSerSerPheCys-42 45-LysIleIleHisThrTyr-50 59-ValIleGlyIleIleAsnGly-65 105-ArgPheLeuAsnArgGly-110 147-PheGlyLeuCysTyrPro-152 Antigenic Index - Jameson-Wolf 10-GlyAsnPheLysLysIleAlaThr-17 19-GlnGlyLeuAspArgLysTyr-25 76-ValLysAsnLysGlnLysPheLeu-83 106-PheLeuAsnArgGlyMetLys-112 132-LeuAsnGluGluGlyGlyTrpMet-139 160-LeuSerArgAspTyrLysHisIle-167 Hydrophilic Regions - Hopp-Woods ll-AsnPheLysLysIleAlaThr-17 19-GlnGlyLeuAspArgLys-24 76-ValLysAsnLysGlnLysPheLeu-83 133-AsnGluGluGlyGly-137 162-ArgAspTyrLysHiε-166 a767 AMPHI Regions - AMPHI 42-LysIleGluValLeuGluPhePheGlyTyrPheCysVal-54 89-GlyLeuAlaArgMetAlaAlaAlaValLys-98 140-LysLysLeuMetArgAlaTyrAspSerProAlaAla-151 156-SerLysMetGlnGlnLeuThrGluGlnTyrArg-166 187-PheAspGlyGlyValHisThrIleLysGluLeuValAla-199 Antigenic Index - Jameson-Wolf 23 -ThrGluGlyGluAspTyrLeuVal-30 33-LysProIleProGlnLysGlnSerGlyLysIleGluVal-45 70-LeuProSerAspAlaTyrLeuArg-77 99-LeuSerGlyLeuLysTyrGlnAla-106 115-TyrGluGlnLysIleArgLeuGluAsnArgSerValAlaGlu-128 130-TrpAlaLeuSerGlnLysGlyPheAspGlyLysLysLeuMetArgAlaTyrAspSerProAla-150 156-SerLysMetGlnGlnLeuThrGluGlnTyrArgIleAspSerThrProThr-172 175-ValGlyGlyLysTyrArgVal-181 183-PheAsnAsnGlyPheAspGlyGly-190 197-LeuValAlaLysValArgGluGluArgLysArgGlnThrProAlaValGlnLys-214 Hydrophilic Regions - Hopp-Woods 23-ThrGluGlyGluAsp-27 33-LysProIleProGlnLysGlnSerGlyLysIleGluVal-45 115-TyrGluGlnLysIleArgLeuGluAsnArgSerValAlaGlu-128 135-LysGlyPheAspGlyLysLysLeuMetArgAlaTyrAsp-147 156-SerLysMetGlnGlnLeu-161 165-TyrArgIleAspSer-169 197-LeuValAlaLysValArgGluGluArgLysArgGlnThrProAlaValGlnLys-214 a768 AMPHI Regions - AMPHI 1-MetAsnIleLysHisLeuIleThrAlaAlaLeuIleAlaSerAlaAlaPheAlaAlaGlnAlaAlaProGlnLy sProValSerAlaAlaGlnThrAlaGlnHisSerAlaValTrpIleAspValArgSerGluGlnGluPheSerGlu GlyHisLeuHisAsnAlaValAsnlleProValAspGlnlleValArgArglleHisGluAlaAlaProAspLysA spThrProValAsnLeuTyrCysArgSerGlyArgArgAlaGluAlaAlaLeuGlnGluLeuLysLysAlaGlyTy rThrAsnValAlaAsnHisGlyGlyTyrGluAspLeuLeuLysLysGlyMetLys Antigenic Index - Jameson-Wolf 1-MetAsnIleLysHisLeuIleThrAlaAlaLeuIleAlaSerAlaAlaPheAlaAlaGlnAlaAlaProGlnLy ΞProValSerAlaAlaGlnThrAlaGlnHisSerAlaValTrpIleAspValArgSerGluGlnGluPheSerGlu GlyHisLeuHisAsnAlaValAsnlleProValAspGlnlleValArgArglleHisGluAlaAlaProAspLysA spThrProValAsnLeuTyrCysArgSerGlyArgArgAlaGluAlaAlaLeuGlnGluLeuLysLysAlaGlyTy rThrAsnValAlaAsnHisGlyGlyTyrGluAspLeuLeuLysLysGlyMetLys Hydrophilic Regions - Hopp-Woods 1-MetAsnIleLysHisLeuIleThrAlaAlaLeuIleAlaSerAlaAlaPheAlaAlaGlnAlaAlaProGlnLy sProValSerAlaAlaGlnThrAlaGlnHisSerAlaValTrpIleAspValArgSerGluGlnGluPheSerGlu GlyHisLeuHisAsnAlaValAsnlleProValAspGlnlleValArgArglleHisGluAlaAlaProAspLysA spThrProValAsnLeuTyrCysArgSerGlyArgArgAlaGluAlaAlaLeuGlnGluLeuLysLysAlaGlyTy rThrAsnValAlaAsnHisGlyGlyTyrGluAspLeuLeuLysLysGlyMetLys-119 a769 AMPHI Regions - AMPHI 1-LeuIleMetValIlePheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLeuLeuPr oLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProArgGluProAspLeuArgSerArgProGluPheArgLeu HisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuGlnl leAspGlyGluThrLeuLeuLysAsnProGluLeuLeuSerArgAlaMetTyrSerAlaValValSerAsnAsnll eAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaGlnGlnAspLysMetLeuAlaLeuTyrAlaGln GlylleLeuAlaGlnAlaAspGlyArgValLysGluAlalleSerHisTyrArgGluLeuIleValAlaGlnProA spAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAsnArgGlnAsnGluAlaAlaAlaAspGlnPh eAspArgLeuLysAlaGluAsnLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArgGlu ArgAspAlaTrpLysValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysArgGlnG InTyrGlyLysTrpThrPheProLysGlnValAspGlyThrAlaValAsnTyrArgLeuGlyAlaGluLysLysTr pSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLysPhe AsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspAlaGlyLeuAlaValPheH isGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrThrAsnGlyAlaArgLeuTyrPheAsnArgTrpGlnTh rProLysTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAεnThrArgArgAlaArgSerAspAsnThr HisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpMetGlyGlyLeuAspPheTyrA rgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTrpGl yGlySerGlyLeuSerSerLeuLeuArgLeuGlyAlaAlaLysArgHisTyrGluLysProGlyPhePheSerGly PheLysGlyGluArgArgArgAspLysGluLeuAsnThrSerLeuSerLeuTrpHisArgAlaLeuHisPheLysG lylleThrProArgLeuThrLeuSerHisArgGluThrArgSerAsnAspValPheAsnGluTyrGluLysAsnAr gAlaPheValGluPheAsnLysThrPhe-490 Antigenic Index - Jameson-Wolf 1-LeuIleMetValIlePheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLeuLeuPr oLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProArgGluProAspLeuArgSerArgProGluPheArgLeu HisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuGlnl leAspGlyGluThrLeuLeuLysAsnProGluLeuLeuSerArgAlaMetTyrSerAlaValValSerAsnAsnll eAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaGlnGlnAspLysMetLeuAlaLeuTyrAlaGln GlylleLeuAlaGlnAlaAspGlyArgValLyεGluAlalleSerHisTyrArgGluLeuIleValAlaGlnProA spAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAsnArgGlnAsnGluAlaAlaAlaAspGlnPh eAspArgLeuLysAlaGluAsnLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArgGlu ArgAspAlaTrpLysValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysArgGlnG InTyrGlyLysTrpThrPheProLysGlnValAspGlyThrAlaValAΞnTyrArgLeuGlyAlaGluLysLysTr pSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLysPhe AsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspAlaGlyLeuAlaValPheH isGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrThrAsnGlyAlaArgLeuTyrPheAsnArgTrpGlnTh rProLysTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAsnThrArgArgAlaArgSerAspAsnThr HisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpMetGlyGlyLeuAspPheTyrA rgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTrpGl yGlySerGlyLeuSerSerLeuLeuArgLeuGlyAlaAlaLysArgHisTyrGluLysProGlyPhePheSerGly PheLysGlyGluArgArgArgAspLysGluLeuAsnThrSerLeuSerLeuTrpHisArgAlaLeuHisPheLysG lylleThrProArgLeuThrLeuSerHisArgGluThrArgSerAsnAspValPheAsnGluTyrGluLysAsnAr gAlaPheValGluPheAsnLysThrPhe-490 Hydrophilic Regions - Hopp-Woods 1-LeuIleMetValIlePheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLeuLeuPr oLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProArgGluProAspLeuArgSerArgProGluPheArgLeu HisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuGlnl leAspGlyGluThrLeuLeuLysAsnProGluLeuLeuSerArgAlaMetTyrSerAlaValValSerAsnAsnll eAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaGlnGlnAεpLysMetLeuAlaLeuTyrAlaGln GlylleLeuAlaGlnAlaAspGlyArgValLysGluAlalleSerHisTyrArgGluLeuIleValAlaGlnProA spAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAsnArgGlnAsnGluAlaAlaAlaAspGlnPh eAspArgLeuLysAlaGluAsnLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArgGlu ArgAspAlaTrpLyεValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysArgGlnG InTyrGlyLyΞTrpThrPheProLysGlnValAspGlyThrAlaValAsnTyrArgLeuGlyAlaGluLysLysTr pSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLysPhe AsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspAlaGlyLeuAlaValPheH isGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrThrAsnGlyAlaArgLeuTyrPheAsnArgTrpGlnTh rProLysTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAsnThrArgArgAlaArgSerAspAsnThr HisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpMetGlyGlyLeuAspPheTyrA rgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTrpGl yGlySerGlyLeuSerSerLeuLeuArgLeuGlyAlaAlaLysArgHisTyrGluLysProGlyPhePheSerGly PheLysGlyGluArgArgArgAspLysGluLeuAsnThrSerLeuSerLeuTrpHisArgAlaLeuHisPheLysG lylleThrProArgLeuThrLeuSerHisArgGluThrArgSerAsnAspValPheAsnGluTyrGluLysAsnAr gAlaPheValGluPheAsnLysThrPhe-490 a770 AMPHI Regions - AMPHI 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuLeuThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnlleLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaSerValSerCysValGlnThrAlaSerSerlleSerPheAspGluThrAlaValArgLysProLysGl uValPheLysHisGlyAlaSerPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysThr PheAlaTyrLeuValTyrSerAspLysIlelleGlnGlySerProLysAsnSerLeuSerAlaValSerCysPheG lyGlyGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyAsnLeuLeuAlaGlyAlaCysMetlleSe rAsnProIleGluAsnProAspLysArg-186 Antigenic Index - Jameson-Wolf 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuLeuThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnlleLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaSerValSerCysValGlnThrAlaSerSerlleSerPheAεpGluThrAlaValArgLysProLysGl uValPheLysHisGlyAlaSerPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysThr PheAlaTyrLeuValTyrSerAεpLysIlelleGlnGlySerProLysAsnSerLeuSerAlaValSerCysPheG lyGlyGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyAsnLeuLeuAlaGlyAlaCysMetlleSe rAsnProl1eGluAsnProAspLysArg-186 Hydrophilic Regions - Hopp-Woods 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuLeuThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnlleLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaSerValSerCysValGlnThrAlaSerSerlleSerPheAspGluThrAlaValArgLysProLysGl uValPheLysHisGlyAlaSerPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysThr PheAlaTyrLeuValTyrSerAspLysIlelleGlnGlySerProLysAsnSerLeuSerAlaValSerCysPheG lyGlyGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyAsnLeuLeuAlaGlyAlaCysMetlleSe rAsnProIleGluAsnProAspLysArg-186 a771 AMPHI Regions - AMPHI 1-MetAspLeuLeuSerValPheHisLysTyrArgLeuLysTyrAlaValAlaValLeuThrIleLeuLeuLeuAl aAlalleGlyLeuHisAlaSerValTyrArgllePheThrProGluAsnlleArgSerArgLeuGlnGlnSerlle AlaHisThrHisArgLysIleSerPheAspAlaAspIleGlnArgArgLeuLeuProArgProThrVallleLeuL ysAsnLeuThrlleThrGluProGlyGlyAspArgThrAlaValSerValGlnGluThrLysIleGlyLeuSerTr pLysAsnLeuTrpSerAspGlnlleGlnlleGluLysTrpValValSerSerAlaGluLeuAlaLeuThrArgAsp GlyLysGlyValTrpAsnlleGlnAspLeuIleAspSerGlnLysArgGlnAlaSerValAsnArgllelleValG luAsnSerThrValArgLeuAsnPheLeuGlnGluGlnLeuIleLeuLysGluIleAsnLeuAsnLeuGlnSerPr oAspSerSerGlyGlnProPheGluSerSerGlylleLeuValTrpGlyLysLeuSerValProTrpLysSerArg GlyLeuPheLeuSerAspGlylleGlyThrProLysIleSerProPheHisPheGluAlaSerThrSerLeuAspG lyHisGlylleThrlleSerThrThrGlySerProSerValArgPheAsnAlaGlyGlyAlaAspAlaAlaGlyLe uGlyLeuArgAlaAspThrSerPheArgAsnLeuHisLeuThrAlaGlnlleProThrLeuAlaLeuArgAsnAsn SerlleLysIleGluThrValAsnGlyAlaPheThrAlaGlyGlyGluTyrAlaGlnTrpAspGlySerPheLysL euAspLysAlaAsnLeuHisSerGlylleAlaAsnlleGlyAsnAlaGluIleSerGlySerPheLysThrProAr gHisGlnThrAsnPheSerLeuAsnSerProLeuValTrpThrGluAsnLysGlyLeuAspAlaProArgLeuTyr ValSerThrLeuGlnAspThrValAsnArgLeuProGlnProArgPhelleSerArgLeuAspGlySerLeuSerV alProAsnLeuGlnAsnTrpAsnAlaGluLeuAsnGlyThrPheAspArgGlnThrValAlaAlaLysPheArgTy rThrHisGluAspAlaProHisLeuGluAlaAlaValAlaLeuGlnLysLeuAsnLeuThrProTyrLeuAspAsp ValArgGlnGlnAsnGlyLysIlePheProAspThrLeuAlaLysLeuSerGlyAspIleGluAlaHisLeuLysI leGlyLysValGlnLeuProGlyLeuGlnLeuAspAspMetGluThrTyrLeuHisAlaAspLysGlyHisIleAl aLeuSerArgPheLysSerGlyLeuTyrGlyGlyHisThrGluGlyGlylleSerlleAlaAsnThrArgProAla ThrTyrArgLeuGlnGlnAsnAlaSerAsnlleGlnlleGlnProLeuLeuGlnAspLeuPheGlyPheHisSerP heSerGlyAsnGlyAspAlaVallleAspLeuThrAlaGlyGlyGluThrArgLysGluLeuIleArgSerLeuGl nGlySerLeuSerLeuAsnlleSerAsnGlyAlaTrpHisGlylleAspMetAspAsnlleLeuLysAsnGlylle SerGlyLysThrAlaAspAsnAlaAlaProSerThrProPheHisArgPheThrLeuAsnSerGluIleSerAspG lylleSerArgHisIleAspThrGluLeuPheSerAspSerLeuTyrValThrSerAsnGlyTyrThrAsnLeuAs pThrGlnGluLeuSerGluAspValLeuIleArgAsnAlaValHisProLysAsnLysProIleProLeuLysIle ThrGlyThrValAspLysProSerlleThrValAspTyrGlyArgLeuThrGlyGlylleAεnSerArgLysGluL ysGlnLysIleLeuGluAspThrLeuLeuGluGlnTrpGlnTrpLeuLysProLysGluPro-704 Antigenic Index - Jameson-Wolf 1-MetAspLeuLeuSerValPheHisLysTyrArgLeuLysTyrAlaValAlaValLeuThrIleLeuLeuLeuAl aAlalleGlyLeuHisAlaSerValTyrArgllePheThrProGluAsnlleArgSerArgLeuGlnGlnSerlle AlaHisThrHisArgLysIleSerPheAspAlaAspIleGlnArgArgLeuLeuProArgProThrVallleLeuL ysAsnLeuThrlleThrGluProGlyGlyAspArgThrAlaValSerValGlnGluThrLysIleGlyLeuSerTr pLysAsnLeuTrpSerAspGlnlleGlnlleGluLysTr ValValSerSerAlaGluLeuAlaLeuThrArgAsp GlyLysGlyValTrpAεnlleGlnAεpLeuIleAspSerGlnLysArgGlnAlaSerValAsnArgllelleValG luAsnSerThrValArgLeuAsnPheLeuGlnGluGlnLeuIleLeuLysGluIleAsnLeuAsnLeuGlnSerPr oAspSerSerGlyGlnProPheGluSerSerGlylleLeuValTrpGlyLysLeuSerValProTrpLysSerArg GlyLeuPheLeuSerAspGlylleGlyThrProLysIleSerProPheHisPheGluAlaSerThrSerLeuAspG lyHisGlylleThrlleSerThrThrGlySerProSerValArgPheAsnAlaGlyGlyAlaAspAlaAlaGlyLe uGlyLeuArgAlaAεpThrSerPheArgAsnLeuHisLeuThrAlaGlnlleProThrLeuAlaLeuArgAsnAsn SerlleLysIleGluThrValAsnGlyAlaPheThrAlaGlyGlyGluTyrAlaGlnTrpAspGlySerPheLysL euAspLysAlaAsnLeuHisSerGlylleAlaAsnlleGlyAsnAlaGluIleSerGlySerPheLysThrProAr gHisGlnThrAsnPheSerLeuAsnSerProLeuValTrpThrGluAsnLysGlyLeuAspAlaProArgLeuTyr ValSerThrLeuGlnAspThrValAεnArgLeuProGlnProArgPhelleSerArgLeuAspGlySerLeuSerV alProAsnLeuGlnAsnTrpAsnAlaGluLeuAsnGlyThrPheAspArgGlnThrValAlaAlaLysPheArgTy rThrHisGluAspAlaProHisLeuGluAlaAlaValAlaLeuGlnLysLeuAsnLeuThrProTyrLeuAspAsp ValArgGlnGlnAsnGlyLysIlePheProAspThrLeuAlaLysLeuSerGlyAspIleGluAlaHisLeuLysI leGlyLysValGlnLeuProGlyLeuGlnLeuAspAspMetGluThrTyrLeuHisAlaAspLysGlyHisIleAl aLeuSerArgPheLysSerGlyLeuTyrGlyGlyHisThrGluGlyGlylleSerlleAlaAsnThrArgProAla ThrTyrArgLeuGlnGlnAsnAlaSerAsnlleGlnlleGlnProLeuLeuGlnAspLeuPheGlyPheHisSerP heSerGlyAsnGlyAspAlaVallleAspLeuThrAlaGlyGlyGluThrArgLysGluLeuIleArgSerLeuGl nGlySerLeuSerLeuAsnlleSerAsnGlyAlaTrpHisGlylleAspMetAspAsnlleLeuLysAsnGlylle SerGlyLysThrAlaAspAsnAlaAlaProSerThrProPheHisArgPheThrLeuAsnSerGluIleSerAspG lylleSerArgHisIleAspThrGluLeuPheSerAspSerLeuTyrValThrSerAsnGlyTyrThrAsnLeuAs pThrGlnGluLeuSerGluAspValLeuIleArgAsnAlaValHisProLysAsnLysProIleProLeuLysIle ThrGlyThrValAspLysProSerlleThrValAspTyrGlyArgLeuThrGlyGlylleAsnSerArgLysGluL ysGlnLysIleLeuGluAspThrLeuLeuGluGlnTrpGlnTrpLeuLysProLysGluPro-704 Hydrophilic Regions - Hopp-Woods 1-MetAspLeuLeuSerValPheHisLysTyrArgLeuLysTyrAlaValAlaValLeuThrIleLeuLeuLeuAl aAlalleGlyLeuHisAlaSerValTyrArgllePheThrProGluAsnlleArgSerArgLeuGlnGlnSerlle AlaHisThrHisArgLysIleSerPheAspAlaAspIleGlnArgArgLeuLeuProArgProThrVallleLeuL ysAsnLeuThrlleThrGluProGlyGlyAspArgThrAlaValSerValGlnGluThrLysIleGlyLeuSerTr pLysAsnLeuTrpSerAspGlnlleGlnlleGluLysTrpValValSerSerAlaGluLeuAlaLeuThrArgAsp GlyLysGlyValTrpAsnlleGlnAspLeuIleAspSerGlnLysArgGlnAlaSerValAsnArgllelleValG luAsnSerThrValArgLeuAsnPheLeuGlnGluGlnLeuIleLeuLysGluIleAsnLeuAsnLeuGlnSerPr oAspSerSerGlyGlnProPheGluSerSerGlylleLeuValTrpGlyLysLeuSerValProTrpLysSerArg GlyLeuPheLeuSerAspGlylleGlyThrProLysIleSerProPheHisPheGluAlaSerThrSerLeuAspG lyHisGlylleThrlleSerThrThrGlySerProSerValArgPheAsnAlaGlyGlyAlaAspAlaAlaGlyLe uGlyLeuArgAlaAspThrSerPheArgAsnLeuHisLeuThrAlaGlnlleProThrLeuAlaLeuArgAsnAsn SerlleLysIleGluThrValAsnGlyAlaPheThrAlaGlyGlyGluTyrAlaGlnTrpAspGlySerPheLysL euAspLysAlaAsnLeuHisSerGlylleAlaAsnlleGlyAsnAlaGluIleSerGlySerPheLysThrProAr gHisGlnThrAsnPheSerLeuAsnSerProLeuValTrpThrGluAsnLysGlyLeuAspAlaProArgLeuTyr ValSerThrLeuGlnAspThrValAsnArgLeuProGlnProArgPhelleSerArgLeuAspGlySerLeuSerV alProAsnLeuGlnAsnTrpAsnAlaGluLeuAsnGlyThrPheAspArgGlnThrValAlaAlaLysPheArgTy rThrHisGluAspAlaProHisLeuGluAlaAlaValAlaLeuGlnLysLeuAsnLeuThrProTyrLeuAspAsp ValArgGlnGlnAsnGlyLysIlePheProAspThrLeuAlaLysLeuΞerGlyAspIleGluAlaHisLeuLysI leGlyLysValGlnLeuProGlyLeuGlnLeuAspAspMetGluThrTyrLeuHisAlaAspLysGlyHisIleAl aLeuSerArgPheLysSerGlyLeuTyrGlyGlyHisThrGluGlyGlylleSerlleAlaAsnThrArgProAla ThrTyrArgLeuGlnGlnAsnAlaSerAsnlleGlnlleGlnProLeuLeuGlnAspLeuPheGlyPheHisSerP heSerGlyAsnGlyAspAlaVallleAspLeuThrAlaGlyGlyGluThrArgLysGluLeuIleArgSerLeuGl nGlySerLeuSerLeuAsnlleSerAsnGlyAlaTrpHisGlylleAspMetAspAsnlleLeuLysAsnGlylle SerGlyLysThrAlaAspAsnAlaAlaProSerThrProPheHisArgPheThrLeuAsnSerGluIleSerAspG lylleSerArgHisIleAspThrGluLeuPheSerAspSerLeuTyrValThrSerAsnGlyTyrThrAsnLeuAs pThrGlnGluLeuSerGluAspValLeuIleArgAsnAlaValHisProLysAsnLysProIleProLeuLysIle ThrGlyThrValAspLysProSerlleThrValAspTyrGlyArgLeuThrGlyGlylleAsnSerArgLysGluL ysGlnLysIleLeuGluAspThrLeuLeuGluGlnTrpGlnTrpLeuLysProLysGluPro-704 a772 AMPHI Regions - AMPHI 1-MetPheGlyAlaValLeuArgIleAspAlaAspCysLeuGlnIleIleValAlaCysLysLeuPheGlnIleVa lAlaTyrGlyPheAlaAlaLeuValGluGlyGluPheHisGluPheGlyGluMetLeuGluIleValArgLeuAla AspThrValPheHisArgAsnHisAlaAspAspGlyArglleHisPheArgArgGlyValGluArgPheGlyArgH isValAsnGlnHisPheHisIleGluGluIleLeuGlnHisHisAlaGlnAlaAlaValValValAlaPheArgAr gGlyAsnHisThrlleAspHisPhePheLeuGlnHisLysValHisIleAspAspIleValArgHisLeuArgGln LeuGluGlnLysArgArgGlyAsnValValGlyGlnValAlaAspAspPheLeuPheAlaCysAspAlaValGluI leLysLeuGlnTyrlleAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspVa lAlaValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnArgArgGlnThrArgThr AspPheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnL ysIleLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerPheSerValGluThrProProPheAr gAlaValGluSerAspSerlleTrpGluGlyArgAsnSerPheGlnlleArgThrAlaHisArgAlaValLeuTyr ValSerSerCysValLeuLysHisLysCysValTyrSerIleArgLeuMetSerAlaLeu-298 Antigenic Index - Jameson-Wolf 1-MetPheGlyAlaValLeuArgIleAspAlaAspCysLeuGlnIleIleValAlaCysLysLeuPheGlnIleVa lAlaTyrGlyPheAlaAlaLeuValGluGlyGluPheHisGluPheGlyGluMetLeuGluIleValArgLeuAla AspThrValPheHisArgAsnHisAlaAspAspGlyArglleHisPheArgArgGlyValGluArgPheGlyArgH isValAsnGlnHisPheHisIleGluGluIleLeuGlnHisHisAlaGlnAlaAlaValValValAlaPheArgAr gGlyAsnHisThrlleAspHisPhePheLeuGlnHisLysValHisIleAspAspIleValArgHisLeuArgGln LeuGluGlnLysArgArgGlyAsnValValGlyGlnValAlaAspAspPheLeuPheAlaCysAspAlaValGluI leLysLeuGlnTyrlleAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspVa lAlaValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnArgArgGlnThrArgThr AspPheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnL ysIleLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerPheSerValGluThrProProPheAr gAlaValGluSerAspSerlleTrpGluGlyArgAsnSerPheGlnlleArgThrAlaHisArgAlaValLeuTyr ValSerSerCysValLeuLysHisLysCysValTyrSerIleArgLeuMetSerAlaLeu-298 Hydrophilic Regions - Hopp-Woods 1-MetPheGlyAlaValLeuArgIleAspAlaAspCysLeuGlnIleIleValAlaCysLysLeuPheGlnIleVa lAlaTyrGlyPheAlaAlaLeuValGluGlyGluPheHisGluPheGlyGluMetLeuGluIleValArgLeuAla AspThrValPheHisArgAsnHisAlaAspAspGlyArglleHisPheArgArgGlyValGluArgPheGlyArgH isValAsnGlnHisPheHisIleGluGluIleLeuGlnHisHisAlaGlnAlaAlaValValValAlaPheArgAr gGlyAsnHisThrlleAspHisPhePheLeuGlnHisLysValHisIleAspAspIleValArgHisLeuArgGln LeuGluGlnLysArgArgGlyAsnValValGlyGlnValAlaAspAspPheLeuPheAlaCysAspAlaValGluI leLysLeuGlnTyrlleAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspVa lAlaValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnArgArgGlnThrArgThr AspPheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnL ysIleLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerPheSerValGluThrProProPheAr gAlaValGluSerAspSerlleTrpGluGlyArgAsnSerPheGlnlleArgThrAlaHisArgAlaValLeuTyr ValSerSerCysValLeuLysHisLysCysValTyrSerIleArgLeuMetSerAlaLeu-298 a774 AMPHI Regions - AMPHI 1-MetLysThrLysLeuProLeuPheIleIleTrpLeuSerValSerAlaAlaCysSerSerProValSerArgAs nlleGlnAspMetArgLeuGluProGlnAlaGluAlaGlySerSerAspAlalleProTyrProValProThrLeu GlnAspArgLeuAspTyrLeuGluGlyThrLeuValArgLeuSerAsnGluValGluThrLeuAsnGlyLysValL ysAlaLeuGluHisAlaLysThrHisProSerSerArgAlaTyrValGlnLysLeuAspAspArgLysLeuLysGl uHisTyrLeuAsnThrGluGlyGlySerAlaSerAlaHisThrValGluThrAlaGlnAsnLeuTyrAsnGlnAla LeuLysHisTyrLysSerGlyArgPheSerAlaAlaAlaSerLeuLeuLysGlyAlaAspGlyGlyAspGlyGlyS erlleAlaGlnArgSerMetTyrLeuLeuLeuGlnSerArgAlaArgMetGlyAsnCysGluSerVallleGluIl eGlyGlyArgTyrAlaAsnArgPheLysAspSerProThrAlaProGluAlaMetPheLysIleGlyGluCysGln TyrArgLeuGlnGlnLysAspIleAlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGlySerProAlaA 1aLysArgAlaAlaAlaAlaVa1ArgLysArg-238 Antigenic Index - Jameson-Wolf 1-MetLysThrLysLeuProLeuPheIleIleTrpLeuSerValSerAlaAlaCysSerSerProValSerArgAs nlleGlnAspMetArgLeuGluProGlnAlaGluAlaGlySerSerAspAlalleProTyrProValProThrLeu GlnAspArgLeuAspTyrLeuGluGlyThrLeuValArgLeuSerAsnGluValGluThrLeuAsnGlyLysValL ysAlaLeuGluHisAlaLysThrHisProSerSerArgAlaTyrValGlnLysLeuAspAspArgLysLeuLysGl uHisTyrLeuAsnThrGluGlyGlySerAlaSerAlaHisThrValGluThrAlaGlnAsnLeuTyrAsnGlnAla LeuLysHisTyrLysSerGlyArgPheSerAlaAlaAlaSerLeuLeuLysGlyAlaAspGlyGlyAspGlyGlyS erlleAlaGlnArgSerMetTyrLeuLeuLeuGlnSerArgAlaArgMetGlyAsnCysGluSerVallleGluIl eGlyGlyArgTyrAlaAsnArgPheLysAspSerProThrAlaProGluAlaMetPheLysIleGlyGluCysGln TyrArgLeuGlnGlnLysAspIleAlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGlySerProAlaA laLysArgAlaAlaAlaAlaValArgLysArg-238 Hydrophilic Regions - Hopp-Woods 1-MetLysThrLysLeuProLeuPheIleIleTrpLeuSerValSerAlaAlaCysSerSerProValSerArgAs nlleGlnAspMetArgLeuGluProGlnAlaGluAlaGlySerSerAspAlalleProTyrProValProThrLeu GlnAspArgLeuAspTyrLeuGluGlyThrLeuValArgLeuSerAsnGluValGluThrLeuAsnGlyLysValL ysAlaLeuGluHisAlaLysThrHisProSerSerArgAlaTyrValGlnLysLeuAspAspArgLysLeuLysGl uHisTyrLeuAsnThrGluGlyGlySerAlaSerAlaHisThrValGluThrAlaGlnAsnLeuTyrAsnGlnAla LeuLysHisTyrLysSerGlyArgPheSerAlaAlaAlaSerLeuLeuLysGlyAlaAspGlyGlyAspGlyGlyS erlleAlaGlnArgSerMetTyrLeuLeuLeuGlnSerArgAlaArgMetGlyAsnCysGluSerVallleGluIl eGlyGlyArgTyrAlaAsnArgPheLysAspSerProThrAlaProGluAlaMetPheLysIleGlyGluCysGln TyrArgLeuGlnGlnLysAspIleAlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGlySerProAlaA laLysArgAlaAlaAlaAlaValArgLysArg-238 a790 AMPHI Regions - AMPHI 10-GluAlaAlaAlaGluVal-15 44-GlyAsnGlnThrCysSerArgTyrSerAsn-53 89-LysGlnAlaValThr-93 103-ThrGlnAlaTyrAsnGluMetThrLysSerVal-113 166-PheAlaArgThrGlyLysLeu-172 174-GlySerPheAspLeuPheAlaSerVal-182 253-ProSerGluAlaLeuAsp-258 290-ThrAlaProAspValTrpThrVal-297 320-PheLeuArgPheTrpGlnAlaThrArgGlyIle-330 Antigenic Index - Jameson-Wolf 1-MetAlaArgArgSerLysThrPheGluGluAlaAlaAlaGluValGluGluArgPheGlyHisArgGlyIleLy s-25 30-GluGlyThrAlaLysProCysVal-37 39-AsnCysProLysHisGlyAsnGlnThrCysSerArgTyrSer-52 57-GlySerSerTrpGlyCysProSerCysGlyAsnGluGlnAlaAla-71 77-ThrLeuArgLysAsnHisIle-83 95-MetThrLysGlnGluArgIleThr-102 123-AspValGlnGlyAspThrThrIle-130 134-HisThrHisThrHisAsnHisSerAspAlaAspGlyLysAlaLeuSer-149 152-LeuThrProArgProLeuLeuSerAspArgGlnAla-163 167-AlaArgThrGlyLysLeuThrGly-174 194-MetProAspThrSerMet-199 201-ProValIleGluLysGlyAsp-207 213-ProArgMetArgProAlaAspGluAspIleVal-223 227-LeuSerAspLysArgLeuVal-233 248-TyrGlnThrGlyArgProSerGluAlaLeuAspLeuProGluGly-262 270-LeuGluSerLysAsnGlyLeuCysProProHisArgGlnGluGlyVal-285 301-SerAlaSerLysThrSerCysThrArgProThrAlaAlaArgLysSerAla-317 326-AlaThrArgGlyIleProLysThrArgSerTrpArgAsnProAsnAsnAlaCys-343 Hydrophilic Regions - Hopp-Woods 1-MetAlaArgArgSerLysThrPheGluGluAlaAlaAlaGluValGluGluArgPheGlyHisArgGlyIleLy s-25 65-CysGlyAsnGluGlnAlaAla-71 77-ThrLeuArgLysAsnHisIle-83 96-ThrLysGlnGluArgIleThr-102 139-AsnHisSerAspAlaAspGlyLysAlaLeuSer-149 157-LeuLeuSerAspArgGlnAla-163 168-ArgThrGlyLysLeu-172 202-ValIleGluLysGlyAsp-207 213-ProArgMetArgProAlaAspGluAspIleVal-223 227-LeuSerAspLysArgLeuVal-233 251-GlyArgProSerGluAlaLeuAspLeuProGlu-261 270-LeuGluSerLysAsnGlyLeu-276 280-HisArgGlnGluGlyVal-285 301-SerAlaSerLysThrSerCysThrArgProThrAlaAlaArgLysSerAla-317 328-ArgGlyl1eProLysThrArgSerTrpArgAsn-338 a900-2 AMPHI Regions - AMPHI 9-ValValAlaPheAlaArgPhe-15 36-ValGlyLysHisPheArgLysPheCysArgPheArg-47 62-ValGlyLeuLeuArgLeuAlaArgLeuPheHisIleGlyAspAspPheValAspArgPheLeuGlyPhePhe- 85 120-GlnCysGluGluPheProGluAlaValValGluAla-131 198-HisGlnThrLeuGlyGlyAspAlaGly-206 210-ValGlnPheHisHisPheGly-216 233-GlyLysProSerGlyGlyAsnGlyLeuGlyGlyLeuValAsnHisLeuArgLeuValAla-252 268-IleArgValLeuArgArgAlaAspGlyGly-277 279-AspSerThrAspValValAlaGlnMet-287 Antigenic Index - Jameson-Wolf l-LeuArgArgValGlyGlyGln-7 20-ValAspPheArgArgGlnLys-26 38-LysHisPheArgLysPheCysArgPheArgArgArgGlyGluSer-52 56-PheLysGlnArgAla-60 74-GlyAspAspPheValAspArg-80 88-PheProLysArgAsnGlyValAla-95 105-GlnThrAsnGlnGlu-109 118-PheGlyGlnCysGluGluPhePro-125 155-GluHisGluAsnValGlySerHisGluAspArgValAla-167 201-LeuGlyGlyAspAlaGlyGlnAsnPro-209 229-ValGluSerAlaGlyLysProSerGlyGlyAsnGly-240 252-AlaPheAspAspThrValValIleGlyGluGluGluGluGlyPheGly-267 270-ValLeuArgArgAlaAspGlyGlyAlaAspSerThrAsp-282 285-AlaGlnMetArgAspAlaGlyGly-292 311-MetProSerGluArgGluLysAspAlaProIle-321 323-ProAspLeuProProThrSerSerArgGlnGlnThr-334 Hydrophilic Regions - Hopp-Woods l-LeuArgArgValGly-5 2 O-ValAspPheArgArgGlnLys-26 38-LysHisPheArgLysPheCysArgPheArgArgArgGlyGluSer-52 89-ProLysArgAsnGly-93 120-GlnCysGluGluPhePro-125 155-GluHisGluAsnValGlySerHisGluAspArgValAla-167 201-LeuGlyGlyAspAlaGlyGln-207 231-SerAlaGlyLysProSerGly-237 257-ValValIleGlyGluGluGluGluGlyPheGly-267 270-ValLeuArgArgAlaAspGlyGlyAlaAspSerThrAsp-282 285-AlaGlnMetArgAspAlaGly-291 311-MetProSerGluArgGluLysAspAlaProIle-321 326-ProProThrSerSerArgGlnGln-333 a901 AMPHI Regions - AMPHI 20-GlyLeuPheThrValLeuGly-26 55-ValSerLeuThrGluIlePheSerLysSer-64 66-GluAlaPheAlaGluIleTyrAsp-73 84-AlaPheLeuAlaGlyMetGlyGlyIleAlaLeuIle-95 97-ArgLeuValProAsnProHisGluThrLeuAsp-107 124-ValGlyMetMetAlaAlaPhe-130 136-AsnPheProGluGlyLeuAlaThrPhePheAlaThrLeuGlu-149 164-HisAsnIleProGluGlyIleSer-171 190-CysLeuLeuSerGlyLeuAlaGluProLeuGlyAlaAla-202 217-PheGlySerValPheGlyValIleAlaGlyValMet-228 243-TyrSerAspGlyHisGlu-248 Antigenic Index - Jameson-Wolf l-MetProAspPheSerMet-6 33 -SerLysThrProAsnProArgVal-40 61-PheSerLysSerSerGluAlaPhe-68 71-IleTyrAspLysAspHisAla-77 98-LeuValProAsnProHisGluThrLeuAspAlaGlnAspProSerPheGlnGluSerLysArgArgHisIleA la-122 136-AsnPheProGluGly-140 179-AlaThrArgSerArgLysLysThr-186 193-SerGlyLeuAlaGluProLeuGly-200 235-GluLeuLeuProAlaAlaLysArgTyrSerAspGlyHisGluThr-249 Hydrophilic Regions - Hopp-Woods 61-PheSerLysSerSerGluAlaPhe-68 71-IleTyrAspLysAspHisAla-77 102-ProHisGluThrLeuAspAlaGlnAspProSerPheGlnGluSerLysArgArgHisIleAla-122 180-ThrArgSerArgLysLysThr-186 235-GluLeuLeuProAlaAlaLysArgTyrSerAspGlyHisGlu-248 a902 AMPHI Regions - AMPHI 1-LeuHisPheGlnArgIleIleLysCysSerGluGlyIleTrpAlaValGlyAlaArgProThrValGlyPhePh eGlyLysSerPheLysIleThrCysLysHisValValLeuArgArgArgThrValGlnAlaValAspPheThrThr CysLeuPheAlaValGlyHisPheValAspValProAlaTyrValPheAlaCysAspAlaHisThrGlyGlyValA laValLysArgValHisGlySerAspValValGlnAsnSerGlyGlyThrPheCysGlnThrGlnGlyArgArgAs nThrValPheGlyValMetPheGlnlleAlaGluGluProArgSerAlaLeuArgAlaAlaProTyrHisAsnAla ValCysGlyGlyLeuPheGluAspGlyLeuGlyPheLeuArgArgGlyAsnValAlaValAspProAspArgAspV alGlnThrAlaPheGlyPheGlyAsnGlnValValSerArgPheAlaPheValHisLeuArgAlaArgAlaSerVa lAspGlyLysGlyGlyAsnAlaAlallePheGlyAspPheGlyAspAspGlyGlnValLeuMetValValValPro ThrGlnThrGlyPheGluGlyAsnGlyTyrAlaArgArgPheAspHisArgLeuGlnAsnGlyGlyAsnGlnArgL euValLeuHisGlnArgAlaThrGlyLeuAspIleAlaAspPhePheSerGlyThrAlaHisValAspValAspLy sLeuArgProLysAlaAspValValThrArgGlylleArgHisLeuLeuArglleAlaSerGlyAsnLeuHisGly AsnAsnAlaAlaPhelleGlyLysIleAlaAlaValGlnGlyPheSerSerlleSerGluArgArgValAlaGlyG InHisPheAlaHisArgProThrCysAlaLysIleSerAlaLysSerAlaGluArgPheValGlyAsnAlaArgHi sArgArgLysCysAspGlyValValAspLysIleAlaAlaAspValHisAsnGlySerAlaPheGlnLysSerThr ProLeuTyrIlePhe-359 Antigenic Index - Jameson-Wolf 1-LeuHisPheGlnArgIleIleLysCysSerGluGlyIleTrpAlaValGlyAlaArgProThrValGlyPhePh eGlyLysSerPheLysIleThrCysLysHisValValLeuArgArgArgThrValGlnAlaValAspPheThrThr CysLeuPheAlaValGlyHisPheValAspValProAlaTyrValPheAlaCysAspAlaHisThrGlyGlyValA laValLysArgValHisGlySerAspValValGlnAsnSerGlyGlyThrPheCysGlnThrGlnGlyArgArgAs nThrValPheGlyValMetPheGlnlleAlaGluGluProArgSerAlaLeuArgAlaAlaProTyrHisAsnAla ValCysGlyGlyLeuPheGluAspGlyLeuGlyPheLeuArgArgGlyAsnValAlaValAspProAspArgAspV alGlnThrAlaPheGlyPheGlyAsnGlnValValSerArgPheAlaPheValHisLeuArgAlaArgAlaSerVa lAspGlyLysGlyGlyAsnAlaAlallePheGlyAspPheGlyAspAspGlyGlnValLeuMetValValValPro ThrGlnThrGlyPheGluGlyAsnGlyTyrAlaArgArgPheAspHisArgLeuGlnAsnGlyGlyAsnGlnArgL euValLeuHisGlnArgAlaThrGlyLeuAspIleAlaAspPhePheSerGlyThrAlaHisValAspValAspLy sLeuArgProLysAlaAspValValThrArgGlylleArgHisLeuLeuArglleAlaSerGlyAsnLeuHisGly AsnAsnAlaAlaPhelleGlyLysIleAlaAlaValGlnGlyPheSerSerlleSerGluArgArgValAlaGlyG lnHisPheAlaHisArgProThrCysAlaLysIleSerAlaLysSerAlaGluArgPheValGlyAsnAlaArgHi sArgArgLysCysAspGlyValValAspLysIleAlaAlaAspValHisAsnGlySerAlaPheGlnLysSerThr ProLeuTyrIlePhe-359 Hydrophilic Regions - Hopp-Woods 1-LeuHisPheGlnArgIleIleLysCysSerGluGlyIleTrpAlaValGlyAlaArgProThrValGlyPhePh eGlyLysSerPheLysIleThrCysLysHisValValLeuArgArgArgThrValGlnAlaValAspPheThrThr CysLeuPheAlaValGlyHisPheValAspValProAlaTyrValPheAlaCysAspAlaHisThrGlyGlyValA laValLysArgValHisGlySerAspValValGlnAsnSerGlyGlyThrPheCysGlnThrGlnGlyArgArgAs nThrValPheGlyValMetPheGlnlleAlaGluGluProArgSerAlaLeuArgAlaAlaProTyrHisAsnAla ValCysGlyGlyLeuPheGluAspGlyLeuGlyPheLeuArgArgGlyAsnValAlaValAspProAspArgAspV alGlnThrAlaPheGlyPheGlyAsnGlnValValSerArgPheAlaPheValHisLeuArgAlaArgAlaSerVa lAspGlyLysGlyGlyAsnAlaAlallePheGlyAspPheGlyAspAspGlyGlnValLeuMetValValValPro ThrGlnThrGlyPheGluGlyAsnGlyTyrAlaArgArgPheAspHisArgLeuGlnAsnGlyGlyAsnGlnArgL euValLeuHisGlnArgAlaThrGlyLeuAspIleAlaAspPhePheSerGlyThrAlaHisValAspValAspLy sLeuArgProLysAlaAspValValThrArgGlylleArgHisLeuLeuArglleAlaSerGlyAsnLeuHisGly AsnAsnAlaAlaPhelleGlyLysIleAlaAlaValGlnGlyPheSerSerlleSerGluArgArgValAlaGlyG InHisPheAlaHisArgProThrCysAlaLysIleSerAlaLysSerAlaGluArgPheValGlyAsnAlaArgHi sArgArgLysCysAspGlyValValAspLysIleAlaAlaAspValHisAsnGlySerAlaPheGlnLysSerThr ProLeuTyrIlePhe-359 a903-l AMPHI Regions - AMPHI 1-MetLysPhePheProAlaProCysLeuLeuValIleLeuAlaValIleProLeuLysThrLeuAlaAlaAspGl uAsnAspAlaGluLeuIleArgSerMetGlnArgGlnGlnHisIleAspAlaGluLeuLeuThrAspAlaAsnVal ArgPheGluGlnProLeuGluLysAsnAsnTyrValLeuSerGluAspGluThrProCysThrArgValAsnTyrl leSerLeuAspAspLysThrAlaArgLysPheSerPheLeuProSerValLeuMetLysGluThrAlaPheLysTh rGlyMetCysLeuGlySerAsnAsnLeuSerArgLeuGlnLysAlaAlaGlnGlnlleLeuIleValArgGlyTyr LeuThrSerGlnAlallelleGlnProGlnAsnMetAspSerGlylleLeuLysLeuArgValSerAlaGlyGluI leGlyAspIleArgTyrGluGluLysArgAspGlyLysSerAlaGluGlySerlleSerAlaPheAsnAsnLysPh eProLeuTyrArgAsnLysIleLeuAsnLeuArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSer ValLysThrAspIleGlnllelleProSerGluGluGluGlyLysSerAspLeuGlnlleLysTrpGlnGlnAsnL ysProIleArgPheSerlleGlylleAspAspAlaGlyGlyLysThrThrGlyLysTyrGlnGlyAsnValAlaLe uSerPheAspAsnProLeuGlyLeuSerAspLeuPheTyrValSerTyrGlyArgGlyLeuValHisLysThrAsp LeuThrAspAlaThrGlyThrGluThrGluSerGlySerArgSerTyrSerValHisTyrSerValProValLysL ysTrpLeuPheSerPheAsnHisAsnGlyHisArgTyrHisGluAlaThrGluGlyTyrSerValAsnTyrAspTy rAsnGlyLysGlnTyrGlnSerSerLeuAlaAlaGluArgMetLeuTrpArgAsnArgPheHisLysThrSerVal GlyMetLysLeuTrpThrArgGlnThrTyrLysTyrlleAspAspAlaGluIleGluValGlnArgArgArgSerA laGlyTrpGluAlaGluLeuArgHisArgAlaTyrLeuAsnArgTrpGlnLeuAspGlyLysLeuSerTyrLysAr gGlyThrGlyMetArgGlnSerMetProAlaProGluGluAsnGlyGlyGlyThrlleProGlyThrSerArgMet LysIlelleThrAlaGlyLeuAspAlaAlaAlaProPheMetLeuGlyLysGlnGlnPhePheTyrAlaThrAlal leGlnAlaGlnTrpAsnLysThrProLeuValAlaGlnAspLysLeuSerlleGlySerArgTyrThrValArgGl yPheAspGlyGluGlnSerLeuPheGlyGluArgGlyPheTyrTrpGlnAsnThrLeuThrTrpTyrPheHisPro AsnHisGlnPheTyrLeuGlyAlaAspTyrGlyArgValSerGlyGluSerAlaGlnTyrValSerGlyLysGlnL euMetGlyAlaValValGlyPheArgGlyGlyHisLysValGlyGlyMetPheAlaTyrAspLeuPheAlaGlyLy sProLeuHisLysProLysGlyPheGlnThrThrAsnThrValTyrGlyPheAsnLeuAsnTyrSerPhe-580 Antigenic Index - Jameson-Wolf 1-MetLysPhePheProAlaProCysLeuLeuValIleLeuAlaVallleProLeuLysThrLeuAlaAlaAspGl uAsnAspAlaGluLeuIleArgSerMetGlnArgGlnGlnHisIleAspAlaGluLeuLeuThrAspAlaAsnVal ArgPheGluGlnProLeuGluLysAsnAsnTyrValLeuSerGluAspGluThrProCysThrArgValAsnTyrl leSerLeuAspAspLysThrAlaArgLysPheSerPheLeuProSerValLeuMetLysGluThrAlaPheLysTh rGlyMetCysLeuGlySerAsnAsnLeuSerArgLeuGlnLysAlaAlaGlnGlnlleLeuIleValArgGlyTyr LeuThrSerGlnAlallelleGlnProGlnAsnMetAspSerGlylleLeuLysLeuArgValSerAlaGlyGluI leGlyAspIleArgTyrGluGluLysArgAspGlyLysSerAlaGluGlySerlleSerAlaPheAsnAsnLysPh eProLeuTyrArgAsnLysIleLeuAsnLeuArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSer ValLysThrAspIleGlnllelleProSerGluGluGluGlyLysSerAspLeuGlnlleLysTrpGlnGlnAsnL ysProIleArgPheSerlleGlylleAspAspAlaGlyGlyLysThrThrGlyLysTyrGlnGlyAsnValAlaLe uSerPheAspAsnProLeuGlyLeuSerAspLeuPheTyrValSerTyrGlyArgGlyLeuValHisLysThrAsp LeuThrAspAlaThrGlyThrGluThrGluSerGlySerArgSerTyrSerValHisTyrSerValProValLysL ysTrpLeuPheSerPheAsnHisAsnGlyHisArgTyrHisGluAlaThrGluGlyTyrSerValAsnTyrAspTy rAsnGlyLysGlnTyrGlnSerSerLeuAlaAlaGluArgMetLeuTrpArgAsnArgPheHisLysThrSerVal GlyMetLysLeuTrpThrArgGlnThrTyrLysTyrlleAspAspAlaGluIleGluValGlnArgArgArgSerA laGlyTrpGluAlaGluLeuArgHisArgAlaTyrLeuAsnArgTrpGlnLeuAspGlyLysLeuSerTyrLysAr gGlyThrGlyMetArgGlnSerMetProAlaProGluGluAsnGlyGlyGlyThrlleProGlyThrSerArgMet LysIlelleThrAlaGlyLeuAspAlaAlaAlaProPheMetLeuGlyLysGlnGlnPhePheTyrAlaThrAlal leGlnAlaGlnTrpAsnLysThrProLeuValAlaGlnAspLysLeuSerlleGlySerArgTyrThrValArgGl yPheAspGlyGluGlnSerLeuPheGlyGluArgGlyPheTyrTrpGlnAsnThrLeuThrTrpTyrPheHisPro AsnHisGlnPheTyrLeuGlyAlaAspTyrGlyArgValSerGlyGluSerAlaGlnTyrValSerGlyLysGlnL euMetGlyAlaValValGlyPheArgGlyGlyHisLysValGlyGlyMetPheAlaTyrAspLeuPheAlaGlyLy sProLeuHisLysProLysGlyPheGlnThrThrAsnThrValTyrGlyPheAsnLeuAsnTyrSerPhe-580 Hydrophilic Regions - Hopp-Woods 1-MetLysPhePheProAlaProCysLeuLeuValIleLeuAlaValIleProLeuLysThrLeuAlaAlaAspGl uAsnAspAlaGluLeuIleArgSerMetGlnArgGlnGlnHisIleAspAlaGluLeuLeuThrAspAlaAsnVal ArgPheGluGlnProLeuGluLysAsnAsnTyrValLeuSerGluAspGluThrProCysThrArgValAsnTyrl leSerLeuAspAspLysThrAlaArgLysPheSerPheLeuProSerValLeuMetLysGluThrAlaPheLysTh rGlyMetCysLeuGlySerAsnAsnLeuSerArgLeuGlnLysAlaAlaGlnGlnlleLeuIleValArgGlyTyr LeuThrSerGlnAlallelleGlnProGlnAsnMetAspSerGlylleLeuLysLeuArgValSerAlaGlyGluI leGlyAspIleArgTyrGluGluLysArgAspGlyLysSerAlaGluGlySerlleSerAlaPheAsnAsnLysPh eProLeuTyrArgAsnLysIleLeuAsnLeuArgAspValGluGlnGlyLeuGluAsnLeuArgArgLeuProSer ValLysThrAspIleGlnllelleProSerGluGluGluGlyLysSerAspLeuGlnlleLysTrpGlnGlnAsnL ysProIleArgPheSerlleGlylleAspAspAlaGlyGlyLysThrThrGlyLysTyrGlnGlyAsnValAlaLe uSerPheAspAsnProLeuGlyLeuSerAspLeuPheTyrValSerTyrGlyArgGlyLeuValHisLysThrAsp LeuThrAspAlaThrGlyThrGluThrGluSerGlySerArgSerTyrSerValHisTyrSerValProValLysL ysTrpLeuPheSerPheAsnHisAsnGlyHisArgTyrHisGluAlaThrGluGlyTyrSerValAsnTyrAspTy rAsnGlyLysGlnTyrGlnSerSerLeuAlaAlaGluArgMetLeuTrpArgAsnArgPheHisLysThrSerVal GlyMetLysLeuTrpThrArgGlnThrTyrLysTyrlleAspAspAlaGluIleGluValGlnArgArgArgSerA laGlyTrpGluAlaGluLeuArgHisArgAlaTyrLeuAsnArgTrpGlnLeuAspGlyLysLeuSerTyrLysAr gGlyThrGlyMetArgGlnSerMetProAlaProGluGluAsnGlyGlyGlyThrlleProGlyThrSerArgMet LysIlelleThrAlaGlyLeuAspAlaAlaAlaProPheMetLeuGlyLysGlnGlnPhePheTyrAlaThrAlal leGlnAlaGlnTrpAsnLysThrProLeuValAlaGlnAspLysLeuSerlleGlySerArgTyrThrValArgGl yPheAspGlyGluGlnSerLeuPheGlyGluArgGlyPheTyrTrpGlnAsnThrLeuThrTrpTyrPheHisPro AsnHisGlnPheTyrLeuGlyAlaAspTyrGlyArgValSerGlyGluSerAlaGlnTyrValSerGlyLysGlnL euMetGlyAlaValValGlyPheArgGlyGlyHisLysValGlyGlyMetPheAlaTyrAspLeuPheAlaGlyLy sProLeuHisLysProLysGlyPheGlnThrThrAsnThrValTyrGlyPheAsnLeuAsnTyrSerPhe-580 a904 AMPHI Regions - AMPHI 1-MetMetGlnHisAsnArgPhePheAlaValGlyAlaGlyGlyAspAspGlyAspArgArgThrAlaAspPhePh eAsnProPheGlnlleCysPheGlylleGlyArgCysValValAlaPheHisAlaGluSerGlyPheAlaProThr GlyHisGlyPheValAsnArgLeuAlaGlyPheTyrArglleArgAlaAlaArgGlnAspValGlyPheAlaAlaV alGlyGlnPheValAlaAspAlaAspIleAspGlyPheAsnAlaValHisTyrlleGluPheGlyAsnThrHisTh rGlyAsnAlaValAspLeuAspGlyAlaPheGlnGlyGlyGlylleLysProAlaAlaAlaAlaCysAlaSerGly TyrArgThrGluPheValSerAlaPheCysGlnThrCysSerAspPheValGluGlnPheGlyArgGluArgAlaA rgThrAspAlaArgGlylleGlyPheAspAspAlaGlnAsnllelleGlnHisLeuArgAlaTyrAlaArgAlaCy sArgSerArgAlaGlyGluAlaValGlyArgSerAsnGluGlyValSerAlaValValAspValGlnGlnArgThr LeuArgAlaPheLysGlnGlnPhePheAlaValPheValPhePheValGlnHisAlaGlyHisValGlyAsnHisA rgArgAsnAlaArgArgAspPhePheAspAsnArgHisHisValPheArgPheHisArgLeuGlyIleValGlnMe tLeuGlnLeuAspValVallleSerLysAspGlylleGlnPhePheThrGlnPhePheArgMetGlnGlnlleGly GlyAlaAsnGlyAlaAlaCysHisPheValPheValGlyArgAlaAspAlaAlaAlaGlyArgAlaAspPheAlaP heAlaAlaArgCysPheSerGlyLeuValGluArgAspVallleArgGlnAspGlnArgAlaGlyArgArgAspPh eGlnThrAlaPheAspValPheHisAlaCysArgValGlnLeuValAspPheAlaGlnGlnGlyPheGlyGlyAsp AspAsnAlaArgThrAspGluAlaValGlnThrPheMetGlnAspAlaAlaArgAsnGlnAlaGlnAsnGlyPheP heAlaAlaAspAsnGlnGlyMetThrArglleValAlaAlaLeuGluAlaHisHisAlaSerGlyPhePheArgGl nProValAsnAspPheThrPheThrLeuValAlaProLeuCysAlaAspTyrTyrAsnllePheSerHisSerHis 11eThrXxxArgTyr-435 Antigenic Index - Jameson-WoIf 1-MetMetGlnHisAsnArgPhePheAlaValGlyAlaGlyGlyAspAspGlyAspArgArgThrAlaAspPhePh eAsnProPheGlnlleCysPheGlylleGlyArgCysValValAlaPheHisAlaGluSerGlyPheAlaProThr GlyHisGlyPheValAsnArgLeuAlaGlyPheTyrArglleArgAlaAlaArgGlnAspValGlyPheAlaAlaV alGlyGlnPheValAlaAspAlaAspIleAspGlyPheAsnAlaValHisTyrlleGluPheGlyAsnThrHisTh rGlyAsnAlaValAspLeuAspGlyAlaPheGlnGlyGlyGlylleLysProAlaAlaAlaAlaCysAlaSerGly TyrArgThrGluPheValSerAlaPheCysGlnThrCysSerAspPheValGluGlnPheGlyArgGluArgAlaA rgThrAspAlaArgGlylleGlyPheAspAspAlaGlnAsnllelleGlnHisLeuArgAlaTyrAlaArgAlaCy sArgSerArgAlaGlyGluAlaValGlyArgSerAsnGluGlyValSerAlaValValAspValGlnGlnArgThr LeuArgAlaPheLysGlnGlnPhePheAlaValPheValPhePheValGlnHisAlaGlyHisValGlyAsnHisA rgArgAsnAlaArgArgAspPhePheAspAsnArgHisHisValPheArgPheHisArgLeuGlyIleValGlnMe tLeuGlnLeuAspValVallleSerLysAspGlylleGlnPhePheThrGlnPhePheArgMetGlnGlnlleGly GlyAlaAsnGlyAlaAlaCysHisPheValPheValGlyArgAlaAspAlaAlaAlaGlyArgAlaAspPheAlaP heAlaAlaArgCysPheSerGlyLeuValGluArgAspVallleArgGlnAspGlnArgAlaGlyArgArgAspPh eGlnThrAlaPheAspValPheHisAlaCysArgValGlnLeuValAspPheAlaGlnGlnGlyPheGlyGlyAsp AspAsnAlaArgThrAspGluAlaValGlnThrPheMetGlnAspAlaAlaArgAsnGlnAlaGlnAsnGlyPheP heAlaAlaAspAsnGlnGlyMetThrArglleValAlaAlaLeuGluAlaHisHisAlaSerGlyPhePheArgGl nProValAsnAspPheThrPheThrLeuValAlaProLeuCysAlaAspTyrTyrAsnllePheSerHisSerHis 11eThrXxxArgTyr-435 Hydrophilic Regions - Hopp-Woods 1-MetMetGlnHisAsnArgPhePheAlaValGlyAlaGlyGlyAspAspGlyAspArgArgThrAlaAspPhePh eAsnProPheGlnlleCysPheGlylleGlyArgCysValValAlaPheHisAlaGluSerGlyPheAlaProThr GlyHisGlyPheValAsnArgLeuAlaGlyPheTyrArglleArgAlaAlaArgGlnAspValGlyPheAlaAlaV alGlyGlnPheValAlaAspAlaAspIleAspGlyPheAsnAlaValHisTyrlleGluPheGlyAsnThrHisTh rGlyAsnAlaValAspLeuAspGlyAlaPheGlnGlyGlyGlylleLysProAlaAlaAlaAlaCysAlaSerGly TyrArgThrGluPheValSerAlaPheCysGlnThrCysSerAspPheValGluGlnPheGlyArgGluArgAlaA rgThrAspAlaArgGlylleGlyPheAspAspAlaGlnAsnllelleGlnHisLeuArgAlaTyrAlaArgAlaCy sArgSerArgAlaGlyGluAlaValGlyArgSerAsnGluGlyValSerAlaValValAspValGlnGlnArgThr LeuArgAlaPheLysGlnGlnPhePheAlaValPheValPhePheValGlnHisAlaGlyHisValGlyAsnHisA rgArgAsnAlaArgArgAspPhePheAspAsnArgHisHisValPheArgPheHisArgLeuGlyIleValGlnMe tLeuGlnLeuAspValVallleSerLysAspGlylleGlnPhePheThrGlnPhePheArgMetGlnGlnlleGly GlyAlaAsnGlyAlaAlaCysHisPheValPheValGlyArgAlaAspAlaAlaAlaGlyArgAlaAspPheAlaP heAlaAlaArgCysPheSerGlyLeuValGluArgAspVallleArgGlnAspGlnArgAlaGlyArgArgAspPh eGlnThrAlaPheAspValPheHisAlaCysArgValGlnLeuValAspPheAlaGlnGlnGlyPheGlyGlyAsp AspAsnAlaArgThrAspGluAlaValGlnThrPheMetGlnAspAlaAlaArgAsnGlnAlaGlnAsnGlyPheP heAlaAlaAspAsnGlnGlyMetThrArglleValAlaAlaLeuGluAlaHisHisAlaSerGlyPhePheArgGl nProValAsnAspPheThrPheThrLeuValAlaProLeuCysAlaAspTyrTyrAsnllePheSerHisSerHis 11eThrXxxArgTyr-435 a907 AMPHI Regions - AMPHI 1-Me LysLysProThrAspThrLeuProValAsnLeuGlnArgArgArgLeuLeuCysAlaAlaGlyAlaLeuLe uLeuSerProLeuAlaGlnAlaGlyAlaGlnArgGluGluThrLeuAlaAspAspValAlaSerValMetArgSer SerValGlySerlleAsnProProArgLeuValPheAspAsnProLysGluGlyGluArgTrpLeuSerAlaMetS erAlaArgLeuAlaArgPheValProAspGluGluGluArgArgArgLeuLeuValAsnlleGlnTyrGluSerSe rArgAlaGlyLeuAspThrGlnlleValLeuGlyLeuIleGluValGluSerAlaPheArgGlnTyrAlalleSer GlyValGlyAlaArgGlyLeuMetGlnValMetProPheTrpLysAsnTyrlleGlyLysProAlaHisAsnLeuP heAspIleArgThrAsnLeuArgTyrGlyCysThrlleLeuArgHisTyrArgAsnLeuGluLysGlyAsnlleVa lArgAlaLeuAlaArgPheAsnGlySerLeuGlySerAsnLysTyrProAsnAlaValLeuGlyAlaTrpArgAsn ArgTrpGlnTrpArg-207 Antigenic Index - Jameson-Wolf 1-MetLysLysProThrAspThrLeuProValAsnLeuGlnArgArgArgLeuLeuCysAlaAlaGlyAlaLeuLe uLeuΞerProLeuAlaGlnAlaGlyAlaGlnArgGluGluThrLeuAlaAspAspValAlaSerValMetArgSer SerValGlySerlleAsnProProArgLeuValPheAspAsnProLysGluGlyGluArgTrpLeuSerAlaMetS erAlaArgLeuAlaArgPheValProAspGluGluGluArgArgArgLeuLeuValAsnlleGlnTyrGluSerSe rArgAlaGlyLeuAspThrGlnlleValLeuGlyLeuIleGluValGluSerAlaPheArgGlnTyrAlalleSer GlyValGlyAlaArgGlyLeuMetGlnValMetProPheTrpLysAsnTyrlleGlyLysProAlaHisAsnLeuP heAspIleArgThrAsnLeuArgTyrGlyCysThrIleLeuArgHisTyrArgAsnLeuGluLysGlyAsnlleVa lArgAlaLeuAlaArgPheAsnGlySerLeuGlySerAsnLysTyrProAsnAlaValLeuGlyAlaTrpArgAsn ArgTrpGlnTrpArg-207 Hydrophilic Regions - Hopp-Woods 1-MetLysLysProThrAspThrLeuProValAsnLeuGlnArgArgArgLeuLeuCysAlaAlaGlyAlaLeuLe uLeuSerProLeuAlaGlnAlaGlyAlaGlnArgGluGluThrLeuAlaAspAspValAlaSerValMetArgSer SerValGlySerlleAsnProProArgLeuValPheAspAsnProLysGluGlyGluArgTrpLeuSerAlaMetS erAlaArgLeuAlaArgPheValProAspGluGluGluArgArgArgLeuLeuValAsnlleGlnTyrGluSerSe rArgAlaGlyLeuAspThrGlnlleValLeuGlyLeuIleGluValGluSerAlaPheArgGlnTyrAlalleSer GlyValGlyAlaArgGlyLeuMetGlnValMetProPheTrpLysAsnTyrlleGlyLysProAlaHisAsnLeuP heAspIleArgThrAsnLeuArgTyrGlyCysThrlleLeuArgHisTyrArgAsnLeuGluLysGlyAsnlleVa lArgAlaLeuAlaArgPheAsnGlySerLeuGlySerAsnLysTyrProAsnAlaValLeuGlyAlaTrpArgAsn ArgTrpGInTrpArg-207 a908 AMPHI Regions - AMPHI 1-MetArgLysSerArgLeuSerGlnTyrLysGlnAsnLysLeuIleGluLeuPheValAlaGlyValThrAlaAr gThrAlaAlaGluLeuValGlyValAsnLysAsnThrAlaAlaTyrTyrPheHisArgLeuArgLeuLeuIleTyr GlnAsnSerProHisLeuGluMetPheAspGlyGluValGluAlaAspGluSerTyrPheGlyGlyGlnArgLysG lyLysArgGlyArgGlyAlaAlaGlyLysValAlaValPheGlyLeuLeuLysArgAsnGlyLysValTyrThrVa lThrValProAsnThrGlnThrAlaThrLeuPheProIlelleArgGluGlnValLysProAspSerlleValTyr ThrAspCysTyrArgSerTyrAspValLeuAspValArgGluPheSerHisPheSerPheAlaGluThrSerPheS erTyrGlnSerGlnHisThrPheCysArgThrThrLysProTyr-166 Antigenic Index - Jameson-Wolf 1-MetArgLysSerArgLeuSerGlnTyrLysGlnAsnLysLeuIleGluLeuPheValAlaGlyValThrAlaAr gThrAlaAlaGluLeuValGlyValAsnLysAsnThrAlaAlaTyrTyrPheHisArgLeuArgLeuLeuIleTyr GlnAsnSerProHisLeuGluMetPheAspGlyGluValGluAlaAspGluSerTyrPheGlyGlyGlnArgLysG lyLysArgGlyArgGlyAlaAlaGlyLysValAlaValPheGlyLeuLeuLysArgAsnGlyLysValTyrThrVa lThrValProAsnThrGlnThrAlaThrLeuPheProIlelleArgGluGlnValLysProAspSerlleValTyr ThrAspCysTyrArgSerTyrAspValLeuAspValArgGluPheSerHisPheSerPheAlaGluThrSerPheS erTyrGlnSerGlnHisThrPheCysArgThrThrLysProTyr-166 Hydrophilic Regions - Hopp-Woods 1-MetArgLysSerArgLeuSerGlnTyrLysGlnAsnLysLeuIleGluLeuPheValAlaGlyValThrAlaAr gThrAlaAlaGluLeuValGlyValAsnLysAsnThrAlaAlaTyrTyrPheHisArgLeuArgLeuLeuIleTyr GlnAsnSerProHisLeuGluMetPheAspGlyGluValGluAlaAspGluSerTyrPheGlyGlyGlnArgLysG lyLysArgGlyArgGlyAlaAlaGlyLysValAlaValPheGlyLeuLeuLysArgAsnGlyLysValTyrThrVa IThrValProAsnThrGlnThrAlaThrLeuPheProIlelleArgGluGlnValLysProAspSerlleValTyr ThrAspCysTyrArgSerTyrAspValLeuAspValArgGluPheSerHisPheSerPheAlaGluThrSerPheS erTyrGlnSerGlnHisThrPheCysArgThrThrLysProTyr-166 a909 AMPHI Regions - AMPHI 71-GlyAsnAsnAlaAspGlu-76 Antigenic Index - Jameson-Wolf 22-ThrTyrGlnAspGlyAsnGlyLysThrAlaValArgGlnLysTyrProAlaGly-39 45-GlnAspGlySerTyrSerLysAsnMetAsnTyrAsnGlnTyrArgProGluArgHisAla-64 68-AsnGlnThrGlyAsnAsnAlaAspGluGluHisArgGlnHisTrpGlnLysProLysPheGlnAsnArg-90 Hydrophilic Regions - Hopp-Woods 23-TyrGlnAspGlyAsnGlyLysThrAlaValArgGlnLysTyr-36 58-TyrArgProGluArgHisAla-64 72-AsnAsnAlaAspGluGluHisArgGlnHisTrpGln-83 85-ProLysPheGlnAsnArg-90 a910 AMPHI Regions - AMPHI 22-SerAlaGluArgGlnIle-27 39-LysAlaValLysMetLeuGlu-45 58-AspHisTrpGlyLysPro-63 69-AlaTyrLysAspGlyArg-74 Antigenic Index - Jameson-Wolf 19-AlaGlyAspSerAlaGluArgGlnIleTyr-28 30-AspProTyrPheGluGlnAsnArgThrLysAlaValLysMetLeuGluGlnArgGlyTyrGln-50 52-HisAspValAspAlaAspAspHisTrpGly-61 68-GluAlaTyrLysAspGlyArgGluTyrAsp-77 83-ProAspLeuLysIleIleLysGluGlnLeuAspArg-94 Hydrophilic Regions - Hopp-Woods 21-AspSerAlaGluArgGlnIleTyr-28 32-TyrPheGluGlnAsnArgThrLysAlaValLysMetLeuGluGlnArgGly-48 52-HisAspValAspAlaAspAspHisTrpGly-61 68-GluAlaTyrLysAspGlyArgGluTyrAsp-77 86-LysIleIleLysGluGlnLeuAspArg-94 a911 AMPHI Regions - AMPHI 6-LeuGluPheTrpValGlyLeuPhe-13 43-ValTyrAlaAspPheGlyAspIleGly-51 97-ValSerAlaGlnIle-101 118-GlyAspThrGluAsnLeuAla-124 l40-AsnLeuIleGlyLysPheMetThrSerPhe-149 Antigenic Index - Jameson-Wolf 1-MetLysLysAsnlle-5 35-GlyGlySerAspLysThrTyr-41 48-GlyAspIleGlyGlyLeuLysValAsnAlaProValLys-60 74-LeuAspProLysSerTyrGlnAlaArgValArgLeuAspLeuAspGlyLysTyrGlnPheSerSerAspVal- 97 103-ThrSerGlyLeuLeuGly-108 115-GlnGlnGlyGlyAspThrGluAsn-122 149-PheAlaGluLysAsnAlaAspGlyGlyAsnAlaGluLysAlaAlaGlu-164 Hydrophilic Regions - Hopp-Woods l-MetLysLysAsnIle-5 36-GlySerAspLysThr-40 74-LeuAspProLysSerTyrGlnAlaArgValArgLeuAspLeuAspGly-89 116-GlnGlyGlyAspThrGluAsn-122 149-PheAlaGluLysAsnAlaAspGlyGlyAsnAlaGluLysAlaAlaGlu-164 a912 AMPHI Regions - AMPHI 24-ProAlaAspAlaValAsnGlnIle-31 38-ValLeuSerIleLeu-42 62-PheAspPheGlnArgMetThrAlaLeuAlaValGlyAsnProTrpArgThrAlaSerAspAlaGlnLys-84 89-LysGluPheGlnThrLeu-94 169-TyrArgAsnGlnPheGlyGluIleIleLysAlaLys-180 Antigenic Index - Jameson-Wolf l-MetLysLysSerSer-5 29-AsnGlnIleArgGlnAsnAlaThrGln-37 42-LeuLysSerGlyAspAlaAsnThrAlaArgGlnLysAlaGluAla-56 74-AsnProTrpArgThrAlaSerAspAlaGlnLysGlnAlaLeuAlaLysGluPhe-91 104-LeuLysLeuLysAsnAlaAsnValAsnValLysAspAsnProIleValAsnLysGlyGlyLysGluIleIle Val-128 130-AlaGluValGlyValProGlyGlnLysProValAsn-141 146-ThrTyrGlnSerGlyGlyLysTyrArgThr-155 169-TyrArgAsnGlnPhe-173 177-IleLysAlaLysGlyValAspGlyLeuIleAla-187 189-LeuLysAlaLysAsnGlySerLys-196 Hydrophilic Regions - Hopp-Woods l-MetLysLysSerSer-5 31-IleArgGlnAsnAla-35 43-LysSerGlyAspAlaAsnThrAlaArgGlnLysAlaGluAla-56 78-ThrAlaSerAspAlaGlnLysGlnAlaLeuAlaLysGluPhe-91 104-LeuLysLeuLysAsn-108 110-AsnValAsnValLysAspAsnProIleVal-119 121-LysGlyGlyLysGluIleIleVal-128 134-ValProGlyGlnLysProValAsn-141 177-IleLysAlaLysGlyValAsp-183 189-LeuLysAlaLysAsnGlySerLys-196 a913 AMPHI Regions - AMPHI 22-GluThrArgProAlaAspProTyrGluGlyTyrAsnArg-34 53 -ArgGlyTyrArgLysValAlaProLys-61 66-GlyValSerAsnPhePheAsnAsnLeuCysAspValValSer-79 107-LeuGlyGlyLeuIleAspIleAlaGlyAla-116 151-ValArgAspAlaLeuGlyThrGlyIleThrSerValTyrSer-164 193-AspLeuThrAspSerLeuAspGluAlaAla-202 238-LeuValGluSerAla-242 257-SerGluThrGlnAla-261 Antigenic Index - Jameson-Wolf 21-AlaGluThrArgProAlaAspProTyrGluGlyTyrAsn-33 39-PheAsnAspGlnAlaAspArgTyr-46 51-AlaAlaArgGlyTyrArgLysValAlaProLysProValArgAla-65 81-GlySerAsnIleLeu-85 87-LeuAspIleLysArgAlaSerGluAspLeuVal-97 117-GlyGlyIleProAspAsnLysAsnThrLeuGlyAsp-128 132-SerTrpGlyTrpLysAsnSerAsn-139 149-SerThrValArgAspAlaLeu-155 163-TyrSerProLysAsnIle-168 172-ThrProValGlyArgTrpGly-178 185-ValSerThrArgGluGlyLeuLeuAspLeuThrAspSerLeuAspGluAlaAlaIleAspLysTyrSerTyr ThrArgAspLeuTyrMet-214 216-ValArgAlaArgGlnThrGlyAlaThrProAlaGluGlyThrGluAspAsnIleAspIleAspGluLeuVal GluSerAlaGluThrGlyAlaAla-247 250-AlaValGlnGluAspSerValSerGluThrGlnAlaGluAlaAlaGlyGluAlaGluThrGlnProGlyThr GlnProGlyThrGlnPro-279 Hydrophilic Regions - Hopp-Woods 21-AlaGluThrArgProAlaAspProTyrGluGlyTyrAsn-33 40-AsnAspGlnAlaAsp-44 53-ArgGlyTyrArgLysValAlaProLysProValArg-64 87-LeuAspIleLysArgAlaSerGluAspLeuVal-97 118-GlyIleProAspAsnLysAsnThrLeu-126 150-ThrValArgAspAlaLeu-155 186-SerThrArgGluGlyLeuLeuAspLeuThrAspSerLeuAspGluAlaAlaIleAsp-204 216-ValArgAlaArgGlnThrGly-222 224-ThrProAlaGluGlyThrGluAspAsnIleAspIleAspGluLeuValGluSerAlaGluThrGlyAlaAla -247 250-AlaValGlnGluAspSerValSerGluThrGlnAlaGluAlaAlaGlyGluAlaGluThrGlnPro-271 a914-2 AMPHI Regions - AMPHI 6-LeuGlyIleLeuThrAlaCysAlaAlaMet-15 17-AlaPheAlaAspArgIleGlyAspLeu-25 65-PheGlnLysThrPheGlu-70 81-GlnLysValArgGlnAlaCys-87 Antigenic Index - Jameson-Wolf 18-PheAlaAspArgIleGlyAspLeuGluAlaArgLeuAlaGlnLeuGluHisArgValAlaVal-38 40-GluSerGlySerAsnThrValLys-47 50-LeuPheGlySerAsnSer-55 64-ProPheGlnLysThrPheGluAlaSerAspArgAsnGluGlyValAlaArgGlnLysValArgGlnAlaCysA snArgGluThrSerAla-93 95-PheCysGluAspGluAlaIleArgCysArgLysPheAsp-107 Hydrophilic Regions - Hopp-Woods 18-PheAlaAspArgIleGlyAspLeuGluAlaArgLeuAlaGlnLeuGluHisArgValAlaVal-38 67-LysThrPheGluAlaSerAspArgAsnGluGlyValAlaArgGlnLysValArgGlnAlaCysAsnArgGluT hrSer-92 95-PheCysGluAspGluAlaIleArgCysArgLysPheAsp-107 a915 AMPHI Regions - AMPHI 9-ValAlaValSerAlaLeuSerAlaCysArgGlnAla-20 31-IleSerAspArgSerVal-36 67-SerThrIleLysGlnMetPheGlyTyrThrLysLeuProGluGluProLysGlyIleArgValIleTyrValT hrAspMetGlyAsnValThrAspTrpThr-100 139-GlnAlaGluLysPhe-143 Antigenic Index - Jameson-Wolf 15-SerAlaCysArgGlnAlaGluGluGlyProProProLeuProArgGlnIleSerAspArgSerValGlyHis- 38 43-AsnLeuThrGluHisAsnGlyProLysAla-52 57-AsnGlyLysProAspGlnProVal-64 75-TyrThrLysLeuProGluGluProLysGlyIle-85 97-ThrAspTrpThrAsnProAsnAlaAspThrGluTrpMetAspAlaLysLys-113 125-GlyMetGlyAlaGluAspAlaLeuProPheGlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGly GlyLysValValGlyPheAspAspMetProAspThrTyr-161 Hydrophilic Regions - Hopp-Woods 18-ArgGlnAlaGluGluGlyProProProLeu-27 30-GlnIleSerAspArgSerVal-36 46-GluHisAsnGlyProLys-51 58-GlyLysProAspGln-62 77-LysLeuProGluGluProLysGlyIle-85 103-AsnAlaAspThrGluTrpMetAspAlaLysLys-113 127-GlyAlaGluAspAlaLeu-132 135-GlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGlyGlyLys-150 155-AspAspMetProAsp-159 a917 AMPHI Regions - AMPHI 6-ProLeuAlaValLeuThrAlaLeuLeuLeu-15 37-ValLeuLysIleTyrAsnTrpSerGluTyrValAspProGluThrValAlaAsp-54 99-1leLysAlaGlyAlaTyrGlnLys11eAspLysSerLeu-111 124-ArgLeuMetAspGlyValAspPro-131 152-ArgValLysLysAlaLeu-157 188-AspSerAlaAlaGlu-192 206-AsnSerSerAsnThrGluAspIleArgGluAlaThr-217 292-AlaLysAsnValAlaAsnAlaHisLysTyrIleAsnAspPheLeuAsp-307 325-LysProAlaArgGluLeuMetGluAsp-333 Antigenic Index - Jameson-Wolf 18-CysGlyGlySerAspLysProProAlaGluLysProAlaProAlaGluAsnArgAsnVal-37 44-SerGluTyrValAspProGluThrValAlaAspPheGluLysLysAsnGlyIleLysValThr-64 68-TyrAspSerAspGluThrLeuGluSerLysValLeuThrGlyLysSerGlyTyrAsp-86 102-GlyAlaTyrGlnLysIleAspLysSerLeuIleProAsnTyrLysHisLeuAsnProGluMetMetArgLeu MetAspGlyValAspProGlyHisGluTyr-135 149-AsnThrGluArgValLysLysAlaLeuGlyThrAspLysLeuProAspAsnGln-166 171-PheAspProGluTyrThrSerLysLeuLysGlnCysGly-183 201-LeuGlyLysAsnProAsnSerSerAsnThrGluAspIleArgGluAlaThrAlaLeuLeuLysLysAsnArg ProAsnIleLysArgPheThrSerSerGlyPheIle-236 238-AspLeuAlaArgGlyAspThr-244 255-AsnIleAlaLysArgArgAlaGluGluAlaGlyGlyLysGluLysIleArgValMetMetProLysGluGly ValGly-280 287-ValIleProLysAspAlaLysAsnValAlaAsn-297 305-PheLeuAspProGluValSerAlaLysAsnGlyAsn-316 320-TyrAlaProSerSerLysProAlaArgGluLeuMetGluAspGluPheLysAsnAspAsnThrIlePhePro ThrGluGluAspLeuLysAsn-350 368-GlnTrpGlnAspValLysAlaGlyLys-376 Hydrophilic Regions - Hopp-Woods 19-GlyGlySerAspLysProProAlaGluLysProAlaProAlaGluAsnArgAsnVal-37 47-ValAspProGluThrValAlaAspPheGluLysLysAsnGlyIle-61 68-TyrAspSerAspGluThrLeuGluSerLysValLeuThr-80 105-GlnLysIleAspLysSerLeu-lll 121-GluMetMetArgLeuMetAspGlyValAspProGlyHis-133 149-AsnThrGluArgValLysLysAlaLeuGlyThrAspLysLeuProAspAsnGln-166 174-GluTyrThrSerLysLeuLysGln-181 204-AsnProAsnSerSerAsnThrGluAspIleArgGluAlaThrAlaLeuLeuLysLysAsnArgProAsnIle LysArgPheThr-231 238-AspLeuAlaArgGlyAspThr-244 255-AsnIleAlaLysArgArgAlaGluGluAlaGlyGlyLysGluLysIleArgValMetMetProLysGluGly -278 290-LysAspAlaLysAsnValAlaAsn-297 305-PheLeuAspProGluValSerAlaLysAsn-314 322-ProSerSerLysProAlaArgGluLeuMetGluAspGluPheLysAsnAspAsn-339 343-ProThrGluGluAspLeuLysAsn-350 370-GlnAspValLysAlaGlyLys-376 a919 AMPHI Regions - AMPHI 13-IleAlaAlaAlaIleLeu-18 24-LysSerIleGlnThrPheProGln-31 37-IleAsnGlyProAspArgProValGlyIleProAsp-48 76-AspPheAlaLysSerLeuGln-82 98-GlnAspValCysAlaGlnAlaPheGlnThrProVal-109 119-GluArgTyrPheThr-123 133-LeuAlaGlyThrValThrGlyTyrTyrGlu-142 161-GlyIleProAspAspPheIleSerValPro-170 176-ArgSerGlyLysAlaLeuValArgIleArgGln-186 191-SerGlyThrIleAspAsnThrGlyGlyThr-200 308-GlnGlyIleLysAlaTyrMetGlnGlnAsnProGlnArgLeuAlaGluValLeu-325 348-AlaLeuGlyThrProLeuMetGlyGluTyrAlaGlyAlaVal-361 382 -ArgLysAlaLeuAsnArg-387 Antigenic Index - Jameson-Wolf 21-CysGlnSerLysSerIleGlnThr-28 30-ProGlnProAspThr-34 36-ValIleAsnGlyProAspArgProValGlyIleProAspProAlaGlyThr-52 54-ValGlyGlyGlyGly-58 76-AspPheAlaLysSerLeuGln-82 87-GlyCysAlaAsnLeuLysAsnArgGlnGlyTrpGln-98 121-TyrPheThrProTrp-125 143-ProValLeuLysGlyAspAspArgArgThrAlaGln-154 l62-IleProAspAspPheIle-167 173-AlaGlyLeuArgSerGlyLysAlaLeuValArgIleArgGlnThrGlyLysAsnSerGlyThrIleAspAsn ThrGlyGlyThrHis-201 215-ThrAlaIleLysGlyArgPheGluGlySerArgPheLeuProTyrHisThrArgAsnGlnIleAsnGlyGly AlaLeuAspGlyLysAlaPro-245 250-AlaGluAspProValGlu-255 262-GlnGlySerGlyArgLeuLysThrProSerGlyLysTyrIleArg-276 278-GlyTyrAlaAspLysAsnGluHisPro-286 293-TyrMetAlaAspLysGlyTyrLeuLysLeuGlyGln-304 316-GlnAsnProGlnArgLeuAlaGlu-323 326-GlyGlnAsnProSer-330 337-LeuThrGlySerSerAsnAspGlyProVal-346 359-GlyAlaValAspArgHisTyr-365 379-ProValThrArgLysAlaLeuAsn-386 393-AspThrGlySerAlaIleLysGlyAlaValArg-403 409-GlyTyrGlyAspGluAlaGlyGluLeuAlaGlyLysGlnLysThrThr-424 431-LeuProAsnGlyMetLysProGluTyrArgPro-441 Hydrophilic Regions - Hopp-Woods 38-AsnGlyProAspArgProValGly-45 90-AsnLeuLysAsnArgGlnGlyTrp-97 144-ValLeuLysGlyAspAspArgArgThrAlaGln-154 175-LeuArgSerGlyLysAlaLeuValArgIleArgGlnThrGlyLysAsnSerGlyThrIleAspAsnThrGly -198 215-ThrAlaIleLysGlyArgPheGluGly-223 239-AlaLeuAspGlyLysAla-244 250-AlaGluAspProVal-254 265-GlyArgLeuLysThrProSer-271 279-TyrAlaAspLysAsnGluHis-285 317-AsnProGlnArgLeuAlaGlu-323 337-LeuThrGlySerSerAsnAspGlyPro-345 380-ValThrArgLysAlaLeuAsn-386 393-AspThrGlySerAlaIle-398 412-AspGluAlaGlyGluLeuAlaGlyLysGlnLysThr-423 434-GlyMetLysProGluTyrArgPro-441 a919 AMPHI Regions - AMPHI 13-IleAlaAlaAlaIleLeu-18 24-LysSerIleGlnThrPheProGln-31 37-IleAsnGlyProAspArgProValGlyIleProAsp-48 76-AspPheAlaLysSerLeuGln-82 98-GlnAspValCysAlaGlnAlaPheGlnThrProVal-109 119-GluArgTyrPheThr-123 133-LeuAlaGlyThrValThrGlyTyrTyrGlu-142 161-GlyIleProAspAspPheIleSerValPro-170 176-ArgSerGlyLysAlaLeuValArgIleArgGln-186 191-SerGlyThrIleAspAsnThrGlyGlyThr-200 308-GlnGlyIleLysAlaTyrMetGlnGlnAsnProGlnArgLeuAlaGluValLeu-325 348-AlaLeuGlyThrProLeuMetGlyGluTyrAlaGlyAlaVal-361 382-ArgLysAlaLeuAsnArg-387 Antigenic Index - Jameson-Wolf 21-CysGlnSerLysSerIleGlnThr-28 30-ProGlnProAspThr-34 36-ValIleAsnGlyProAspArgProValGlyIleProAspProAlaGlyThr-52 54-ValGlyGlyGlyGly-58 76-AspPheAlaLysSerLeuGln-82 87-GlyCysAlaAsnLeuLysAsnArgGlnGlyTrpGln-98 121-TyrPheThrProTrp-125 143-ProValLeuLysGlyAspAspArgArgThrAlaGln-154 162-IleProAspAspPheIle-167 173-AlaGlyLeuArgSerGlyLysAlaLeuValArgIleArgGlnThrGlyLysAsnSerGlyThrIleAspAsn ThrGlyGlyThrHis-201 215-ThrAlaIleLysGlyArgPheGluGlySerArgPheLeuProTyrHisThrArgAsnGlnIleAsnGlyGly AlaLeuAspGlyLysAlaPro-245 250-AlaGluAspProValGlu-255 262-GlnGlySerGlyArgLeuLysThrProSerGlyLysTyrIleArg-276 278-GlyTyrAlaAspLysAsnGluHisPro-286 293-TyrMetAlaAspLysGlyTyrLeuLysLeuGlyGln-304 316-GlnAsnProGlnArgLeuAlaGlu-323 326-GlyGlnAsnProSer-330 337-LeuThrGlySerSerAsnAspGlyProVal-346 359-GlyAlaValAspArgHisTyr-365 379-ProValThrArgLysAlaLeuAsn-386 393-AspThrGlySerAlaIleLysGlyAlaValArg-403 409-GlyTyrGlyAspGluAlaGlyGluLeuAlaGlyLysGlnLysThrThr-424 431-LeuProAsnGlyMetLysProGluTyrArgPro-441 Hydrophilic Regions - Hopp-Woods 38-AsnGlyProAspArgProValGly-45 90-AsnLeuLysAsnArgGlnGlyTrp-97 144-ValLeuLysGlyAspAspArgArgThrAlaGln-154 175-LeuArgSerGlyLysAlaLeuValArgIleArgGlnThrGlyLysAsnSerGlyThrIleAspAsnThrGly -198 215-ThrAlaIleLysGlyArgPheGluGly-223 239-AlaLeuAspGlyLysAla-244 250-AlaGluAspProVal-254 265-GlyArgLeuLysThrProSer-271 279-TyrAlaAspLysAsnGluHis-285 317-AsnProGlnArgLeuAlaGlu-323 337-LeuThrGlySerSerAsnAspGlyPro-345 380-ValThrArgLysAlaLeuAsn-386 393-AspThrGlySerAlaIle-398 412-AspGluAlaGlyGluLeuAlaGlyLysGlnLysThr-423 434-GlyMetLysProGluTyrArgPro-441 a920-2 AMPHI Regions - AMPHI 43-GlyGluPheProGluLeuGluProIleAla-52 118-IleLysGlnMetProAsp-123 135-LysAsnIleValAsnVal-140 163-LeuAspAsnProAlaAsn-168 190-ThrValThrAlaThrPheAspGlyPheAspThrSerAspArgSerLys-205 212-GlnAlaPheSerAspSerThr-218 Antigenic Index - Jameson-Wolf 40-LeuGlyTyrGlyGlu-44 49-GluProIleAlaLysAspArgLeu-56 66-ValThrGluLysGlyLysGluAsnMetIle-75 82-TyrGlnTyrArgSerAsnArgProValLysAspGlySerTyr-95 104-ThrPheTrpSerLysAsnLysAlaGlyTrp-113 120-GlnMetProAspAlaSerTyrCysGluGlnThrArgMetPheGlyLysAsnIleValAsnValGlyHisGlu SerAlaAspThr-147 152-LysProValGlyGlnAsnLeuGlu-159 162-ProLeuAspAsnProAla-167 173-GluArgPheLysVal-177 181-PheArgGlyGluProLeuProAsnAla-189 194-ThrPheAspGlyPheAspThrSerAspArgSerLysThrHisLysThrGluAla-211 213-AlaPheSerAspSerThrAspAspLysGlyGluValAsp-225 237-AsnValGluHisLysAlaAspPheProAspGlnSerValCysGlnLysGlnAlaAsnTyrSer-257 Hydrophilic Regions - Hopp-Woods 49-GluProIleAlaLysAspArgLeu-56 66-ValThrGluLysGlyLysGluAsnMetIle-75 85-ArgSerAsnArgProValLysAspGlySer-94 107-SerLysAsnLysAlaGlyTrp-113 128-GluGlnThrArgMetPheGly-134 142-HisGluSerAlaAsp-146 173-GluArgPheLysVal-177 196-AspGlyPheAspThrSerAspArgSerLysThrHisLysThrGluAla-211 213-AlaPheSerAspSerThrAspAspLysGlyGluValAsp-225 237-AsnValGluHisLysAlaAspPheProAsp-246 248-SerValCysGlnLys-252 a921 AMPHI Regions - AMPHI lO-IleValAlaValLeuSerGlyCysGlnSerIleTyrValProThrLeuThrGluIleProValAsn-31 33-IleAsnThrValLysThr-38 51-HisTrpThrAspValAlaLysIleSerAspGlu-61 72-GlyLysMetThrLysValGlnAlaAlaGlnTyrLeuAsnAsnPheArgLys-88 98-AspSerMetTyrGluIleTyrLeuArg-106 126-GlnAsnAlaLeuArgGlyTrpGlnGlnArg-135 Antigenic Index - Jameson-Wolf 36-ValLysThrGluAlaProAlaLysGlyPheArg-46 56-AlaLysIleSerAspGluAlaThrArg-64 72-GlyLysMetThrLys-76 84-AsnAsnPheArgLysArgLeuValGlyArgAsnAlaValAspAspSerMet-100 108-AlaIleAspSerGlnArgGlyAlaIleAsnThrGluGlnSerLys-122 128-AlaLeuArgGlyTrpGlnGlnArgTrpLysAsnMetAspValLysProAsnAsnProAla-147 Hydrophilic Regions - Hopp-Woods 36-ValLysThrGluAlaProAlaLysGlyPheArg-46 56-AlaLysIleSer spGluAlaThrArg-64 86-PheArgLysArgLeuValGly-92 94-AsnAlaValAspAspSerMet-100 108-AlaIleAspSerGlnArgGlyAlaIleAsnThrGluGlnSerLys-122 136-TrpLysAsnMetAspValLysProAsnAsn-145 a922 AMPHI Regions - AMPHI 16-LeuSerAlaCysThr-20 28-ArgAlaAsnGluAlaGlnAlaPro-35 72-ValArgArgPheValAspAsp-78 89-GluTrpGlnAspPhePheAspLys-96 104-ValLysIleMetHis-108 144-AspAspValAlaGln-148 172-GlyΞerPheArgValAlaAspAlaLeu-180 196-LysGluLeuValGluLeuLeuLysLeuAla-205 222-AlaMetGlyMetPro-226 245-HisArgAspIleTrpGlyAsnValGlyAspValAlaAlaSerIleAlaAsnTyrMetLysGlnHis-266 298-ArgThrValAlaAspLeuLysAlaTyr-306 335-TyrLeuGlyLeuAsnAsnPheTyrThr-343 Antigenic Index - Jameson-Wolf l-MetLysAsnArgLysIleLeu-7 22-MetGluAlaArgProProArgAlaAsnGluAlaGlnAlaProArgAlaAspGluMetLysLysGluSerArgP roAlaPhe-48 61-ValSerAspSerGlyPhe-66 70-AlaAsnValArgArgPheValAspAspGluValGlyLysGlyAspPheSerArgAlaGluTrp-90 107-MetHisArgProSerThrSerArgPro-115 120-ArgThrGlyAsnSerGlyLysAlaLysPheArgGlyAlaArgArgPheTyrAlaGluAsnArgAlaLeuIle -143 145-AspValAlaGlnLysTyrGlyVal-152 163-1leGluThrAsnTyrGlyLysAsnThrGlySer-173 186-AspTyrProArgArgAlaGlyPhePhe-194 203-LysLeuAlaLysGluGluGlyGlyAsp-211 229-MetProSerSerTyrArgLysTrpAlaValAspTyrAspGlyAspGlyHisArgAspIle-248 266-HisGlyTrpArgThrGlyGlyLys-273 281-AlaProGlyAlaAsp-285 290-IleGlyGluLysThrAlaLeu-296 310-ProGlyGluGluLeuAlaAspAspGluLysAlaVal-321 326-GluThrAlaProGly-330 357-ValArgAspIleAlaAsnSerLeuGlyGlyProGlyLeu-369 Hydrophilic Regions - Hopp-Woods l-MetLysAsnArgLysIleLeu-7 22-MetGluAlaArgProProArgAlaAsnGluAlaGlnAlaProArgAlaAspGluMetLysLysGluSerArgP roAlaPhe-48 70-AlaAsnValArgArgPheValAspAspGluValGlyLysGlyAspPheSerArgAlaGluTrp-90 122-GlyAsnSerGlyLysAlaLysPheArgGlyAlaArgArgPheTyrAlaGluAsnArgAlaLeuIle-143 166-AsnTyrGlyLysAsnThrGly-172 187-TyrProArgArgAlaGlyPhePhe-194 203-LysLeuAlaLysGluGluGlyGlyAsp-211 240-TyrAspGlyAspGlyHisArgAspIle-248 290-IleGlyGluLysThrAlaLeu-296 310-ProGlyGluGluLeuAlaAspAspGluLysAlaVal-321 357-ValArgAspIleAla-361 a923-2 AMPHI Regions - AMPHI 9-LeuMetAlaCysAlaAlaPheLeu-16 26-LeuGlyAlaCysTyrAlaIleLeuSerLeuTyrAla-37 63-ProAlaLeuPheGlyGlyTrpAlaGly-71 Antigenic Index - Jameson-Wolf 43-IleAspLysArgArgAlaValArgGlyLysArgArgIleProGluHisArgLeu-60 77-ArgIlePheArgHisLysThrAlaLysLysArgPhe-88 Hydrophilic Regions - Hopp-Woods 43-IleAspLysArgArgAlaValArgGlyLysArgArgIleProGluHisArgLeu-60 77-ArgIlePheArgHisLysThrAlaLysLysArgPhe-88 a925-l AMPHI Regions - AMPHI 66-LysCysGlyGlnThrAlaGln-72 90-HisGlnAlaAlaIleGluGlnLeuLys-98 105-PheAspGluLeuGlu-109 Antigenic Index - Jameson-Wolf 6-PheThrGlyLysGluGluSerMetLeuLeuSerGluLysAspGlyAla-21 25-AsnThrGlyIleGly-29 31-IleProIleLysLeuSerAspAspGlyLysGluLeuTyrValGluArgArgGlnTyrValLysThrAspAlaA laMetLysAspLysIleIleAlaHisGlnLysLysCysGlyGlnThr-70 75-LeuAspAlaArgAsnAlaLeuProSerAsnGlnThrTyrGln-88 95-GluGlnLeuLysArgArgPheGluAlaGluPheAspGluLeuGluLysGluIleLysCysAsnGlyLysProT hr-119 Hydrophilic Regions - Hopp-Woods 7-ThrGlyLysGluGluSerMetLeuLeuSerGluLysAspGlyAla-21 31-IleProIleLysLeuSerAspAspGlyLysGluLeuTyrValGluArgArgGlnTyrValLysThrAspAlaA laMetLysAspLysIleIleAlaHisGlnLysLysCysGlyGln-69 75-LeuAspAlaArgAsnAlaLeu-81 95-GluGlnLeuLysArgArgPheGluAlaGluPheAspGluLeuGluLysGluIleLysCysAsnGlyLys-117 a926 AMPHI Regions - AMPHI 32-HisThrArgSerPhe-36 72-LeuGlySerThrLeuGlyGln-78 98-AlaGluSerAlaGluGluLeuSerArgGln-107 129-GlyAlaProTyrArgIleLeuProAspGlyIle-139 151-AlaAspSerGlyGlyGlnVal-157 Antigenic Index - Jameson-Wolf 19-LeuProGlnAsnAsnGluAsnLeuTrpGlnProSerGluHisThrArgSerPheThrAlaGluGlyArgLeuA laValLysAlaGluGlyLysGlySerTyrAla-53 70-ThrProLeuGlySer-74 79-LeuCysGlnAspArgAspGlyAlaLeu-87 89-ValAspGlyLysGlyAsnValTyr-96 99-GluSerAlaGluGluLeuSerArg-106 122-AlaAspGlyArgProValAlaGlyAlaPro-131 134-IleLeuProAspGlyIleLeu-140 148-GlyArgThrAlaAspSerGlyGlyGln-156 177-GlyMetProSerGluThrGluThrGlnGluGlnCysAla-189 Hydrophilic Regions - Hopp-Woods 36-PheThrAlaGluGlyArgLeuAlaValLysAlaGluGlyLysGlySer-51 80-CysGlnAspArgAspGlyAlaLeu-87 89-ValAspGlyLysGly-93 99-GluSerAlaGluGluLeuSerArg-106 123-AspGlyArgProValAla-128 149-ArgThrAlaAspSerGlyGlyGln-156 180-SerGluThrGluThrGlnGluGlnCysAla-189 a927 AMPHI Regions - AMPHI 13-LeuLeuSerAlaCysSer-18 48-SerTyrAspValAlaArgAspPheTyrLysGlu-58 120-LysGlyTrpGlnGlnAlaLeuPro-127 145-AsnProLysGlnlleArgAspTrpAsnAspLeuAlaLysAspGly-159 197-LysLeuValAlaSerIleLeu-203 Antigenic Index - Jameson-Wolf 18-SerProAlaAlaAspSerAsnHisProSerGlyGlnAsnAlaProAlaAsnThrGluSerAspGlyLysAsnI leThr-43 48-SerTyrAspValAlaArgAspPheTyrLysGluTyrAsnPro-61 67-TyrGlnSerGluHisProGlyThrSer-75 80-GlnSerHisGlyGlySerSerLysGln-88 104-AsnGlnSerSerAspl1eAspLeuLeuGluLysLysGlyLeuVal-118 126-LeuProAspHisAlaAlaProTyrThr-134 142-ArgLysAsnAsnProLysGlnIleArgAspTrpAsnAspLeuAlaLysAspGlyVal-160 166-AsnProLysThrSerGlyAsnGlyArg-174 185-LeuLysThrThrAsnGlyAsnGluGlnGluAlaGlnLys-197 203-LeuLysAsnThrProValPheGluAsnGlyGlyArgAlaProPrProProSerHisAsnAlaThrSer-225 230-SerLeuLeuLysThrLysProThrThrSerAlaLysAsn-242 Hydrophilic Regions - Hopp-Woods 19-ProAlaAlaAspSerAsnHisProSer-27 33-AlaAsnThrGluSerAspGlyLysAsn-41 50-AspValAlaArgAspPheTyrLys-57 67-TyrGlnSerGluHisProGly-73 82-HisGlyGlySerSerLysGln-88 105-GlnSerSerAsplleAspLeuLeuGluLysLysGlyLeuVal-118 142-ArgLysAsnAsnProLysGlnIleArgAspTrpAsnAspLeuAlaLysAspGlyVal-160 167-ProLysThrSerGlyAsnGly-173 187-ThrThrAsnGlyAsnGluGlnGluAlaGlnLys-197 211-AsnGlyGlyArgAlaProPro-217 232-LeuLysThrLysProThrThrSerAlaLysAsn-242 a929 AMPHI Regions - AMPHI 25-ValProAspGlyValLys-30 34-TrpThrLeuLeuAlaMetPheIleGlyValIleAlaAlaIleIle-48 76-GlyAlaAlaMetSerAspAlaLeuSerAlaPhe-86 155-HisProIleMetGlnSerIleAlaGlySerTyrGlySerAsnProAlaLys-171 180-TyrLeuAlaLeuVal-184 204-ProLeuIleValAsnLeuIleAlaGluAsnLeuGly-215 233-GlyValIleAlaPhePhe-238 265-ArgLeuArgGluMetGlyLysMetSer-273 280-AlaValIlePheGlyIle-285 355-LeuGlyLeuIleLysTrpPheSerGlyValLeuAlaGluSerValGlyGlyLeu-372 398-ThrAlaHisIleThrAlaMetPheGlyAlaPhePheAla-410 452-TyrThrThrMetGlyGluTrpTrp-459 Antigenic Index - Jameson-Wolf 25-ValProAspGlyValLysProGln-32 71-ThrAlaAspLysProGlyAlaAlaMet-79 122-GlyArgLysThrLeuGlyIle-128 143-ThrProSerAsnThrAlaArgGlyGlyGly-152 163-GlySerTyrGlySerAsnProAlaLysGlyThrGluGlyLysMetGlyLys-179 187-HisSerAsnProIleSer-192 213-AsnLeuGlySerSerPhe-218 248-TyrProProGluIleLysGluThrProAsn-257 261-PheAlaLysAspArgLeuArgGluMetGlyLysMetSerAlaAspGluIle-277 328-AspValLeuLysGluLysSerAlaTrp-336 Hydrophilic Regions - Hopp-Woods 71-ThrAlaAspLysProGlyAlaAlaMet-79 146-AsnThrAlaArgGly-150 168-AsnProAlaLysGlyThrGluGlyLysMetGlyLys-179 250-ProGluIleLysGluThrProAsn-257 261-PheAlaLysAspArgLeuArgGluMetGlyLysMetSerAlaAspGluIle-277 328-AspValLeuLysGluLysSerAlaTrp-336 a931 AMPHI Regions - AMPHI 43-LysAlaProLysThrValAlaAsnPheValArgTyrAlaArgLys-57 67-ArgValIleGlyGly-71 81-GluAspLeuAlaGlnLysAlaSerAspLys-90 94-AsnGluSerGlyAsnGlyLeuLysAsnThrValGly-105 107-IleAlaMetAlaArgThrAlaAspProAsp-116 120-SerGlnPhePheIle-124 142-ThrValPheGlyArgValGluSerGlyMetAsnThrValSerLysIleAlaArgValLysThrAlaThrArg GlyPhe-167 Antigenic Index - Jameson-Wolf l-MetLysProLysPhe-5 30-ThrAspMetGlyAsn-34 38-ValLeuAspGluSerLysAlaProLysThr-47 53-ArgTyrAlaArgLysGlyPheTyrAspAsnThr11e-64 76-GlyGlyGlyLeuThrGluAspLeuAlaGlnLysAlaSerAspLysAlaValAlaAsnGluSerGlyAsnGlyL euLysAsnThrVal-104 Hl-ArgThrAlaAspProAspSerAlaThr-119 127-ValAspAsnAspSerLeuAsnTyrLysAsnGlyGln-138 145-GlyArgValGluSerGlyMetAsnThrVal-154 156-LysIleAlaArgValLysThrAlaThrArgGlyPhe-167 176-ValLysIleArgArg-180 Hydrophilic Regions - Hopp-Woods l-MetLysProLysPhe-5 30-ThrAspMetGlyAsn-34 38-ValLeuAspGluSerLysAlaProLysThr-47 78-GlyLeuThrGluAspLeuAlaGlnLysAlaSerAspLysAlaValAlaAsnGluSerGlyAsnGlyLeu-100 Hl-ArgThrAlaAspProAspSerAlaThr-119 127-ValAspAsnAspSerLeuAsn-133 145-GlyArgValGluSerGlyMet-151 156-LysIleAlaArgValLysThrAlaThr-164 176-ValLysIleArgArg-180 a933 AMPHI Regions - AMPHI 27-AsnIleProAlaLeuPheProLysHisProPheAspProPheGluAsnIleAsnAsnSerLysArg-48 63-GlyPheAlaGlnGlyLeu-68 78-GluLysProIleArgGlnTyrPheLysGluCysLeuAsnThrGly-92 95-SerAspAspThrCys-99 131-ValGlyAsnTyrIleGluTrpLeu-138 155-AspValAspProPheHisTyrIleGluVal-164 257-GluAsnProIleAspAspLeuLysSerLeuAspGlyHisGlnIleIleLysValAsn-275 304-GlyPhePheThrLys-308 351-TrpLeuArgValIleAspGlyHisSerAsn-360 426-AlaGlyIleTyrAlaThrTrpHis-433 447-TrpValGlnTyrGln-451 462-AlaThrGluArgPheThr-467 469-LysGlyIleThrAlaSer-474 478-GlyTyrAsnAlaLeuLeuAla-484 543-LeuTyrLysAsnIleAlaIleGlu-550 552-PheAlaAlaValAsn-556 601-PheAsnArgGlnThrGly-606 Antigenic Index - Jameson-Wolf 1-LysLysLeuArgAspArgAsnSerGluTyrTrpLysGluGluThrTyrHisIleLysSerAsnAsnArgValTy rPro-26 33-ProLysHisProPheAspProPheGluAsnIleAsnAsnSerLysArgIleSerPheTyrAspLysGluTyrT hrGluAspTyr-60 69-GlyValAlaLysArgAsnGlyGluThrGluLysProIleArg-82 88-CysLeuAsnThrGlyLysTyrSerAspAspThrCysLysSerGlnGlnΞer-104 108-ValArgSerAspIle-112 117-ThrLysIleLysAsnSerHisIleAsnSerGluIle-128 145-LeuSerSerSerGlnGluHisLeuTyrSerAspValAspProPheHis-160 163-GluValThrAspAsnSerHis-169 178-AspGluPheArgLeuGluAsnSerLeuTrpGluProArgTrpAspSerAspValGlyGluLeuLysThrThr AsnAlaAspIleArgPheAsnThrLysSerGluSerLeuLeuValLysGluAspTyrAlaGlyGlyAlaArgPhe- 226 231-GlyLeuLysAspLysValProGluThrPro-240 244-PheGluLysAsnIleThrGlyThrSer-252 255-IlePheGluAsnProIleAspAspLeuLysSerLeuAspGlyHisGlnIleIle-272 274-ValAsnGlyThrAlaAspLysHisAlaPheArgLeuSerGlyLysHisGlnLysGly-292 298-LeuGlnGlnArgProGluGlyPhe-305 308-LysValGlnGluArgAspAspIleSer-316 332-ArgLeuAsnAspLysAsnSerAspIlePheAspArgThrLeuProArgLysGlyLeu-350 355-IleAspGlyHisSerAsnGlnTrpValGlnGlyLysThrAlaProValGluSerAsnArgLysGlyVal-37 7 387-GlnAsnGluSerAsnGlnLeu-393 399-SerGlyGlnAlaGluGlnArgSerThrPheArgAsnProAspThrAspAsnLeuThrThrGlyAsnValLys GlyPheGly-425 435-LeuGlnAspLysGlnThrGlyAlaTyrAlaAspSer-446 451-GlnArgPheArgHisArgIleAsnThrGluAspAlaThrGluArgPheThrSerLysGlyIle-471 486-HisPheThrLysLysGlyAsnArgVal-494 509-ValAsnGlyLysPheSerAspSerGluAsnAla-519 524-LeuGlySerArgGlnLeuGlnSer-531 562-LysProPheGlyValGluMetAspGlyGluArgArgMetIleAsnAsnLysThrAlaIleGluSer-583 589-ValLysIleLysSer-593 600-ThrPheAsnArgGlnThrGlyLysHisHisGlnAlaLysGlnGly-614 Hydrophilic Regions - Hopp-Woods l-LysLysLeuArgAspArgAsnSerGluTyrTrpLysGluGluThrTyrHis-17 35-HisProPheAspPro-39 44-AsnAsnSerLysArgIleSerPheTyrAspLysGluTyrThrGlu-58 70-ValAlaLysArgAsnGlyGluThrGluLysProIle-81 93-LysTyrSerAspAspThrCysLysSerGlnGln-103 117-ThrLysIleLysAsn-121 152-LeuTyrSerAspValAsp-157 178-AspGluPheArgLeuGlu-183 189-ProArgTrpAspSerAspValGlyGluLeuLysThrThrAsnAlaAspIleArgPheAsnThrLysSerGlu SerLeuLeuValLysGluAspTyrAlaGly-222 232-LeuLysAspLysValProGlu-238 246-LysAsnIleThrGly-250 258-AsnProIleAspAspLeuLysSerLeuAsp-267 276-GlyThrAlaAspLysHisAlaPhe-283 285-LeuSerGlyLysHisGlnLys-291 299-GlnGlnArgProGluGlyPhe-305 309-ValGlnGluArgAspAspIle-315 333-LeuAsnAspLysAsnSerAspIlePheAsp-342 366-LysThrAlaProValGluSerAsnArgLysGlyVal-377 388-AsnGluSerAsnGln-392 401-GlnAlaGluGlnArgSerThrPheArgAsnProAspThrAspAsnLeuThr-417 435-LeuGlnAspLysGlnThr-440 451-GlnArgPheArgHisArglleAsnThrGluAspAlaThrGluArgPheThrSer-468 486-HisPheThrLysLysGlyAsnArg-493 512-LysPheSerAspSerGluAsnAla-519 527-ArgGlnLeuGlnSer-531 564-PheGlyValGluMetAspGlyGluArgArgMetIleAsn-576 589-ValLysIleLysSer-593 603-ArgGlnThrGlyLysHisHisGlnAlaLysGlnGly-614 a935 AMPHI Regions - AMPHI 41-ValSerAspLysTrpAla-46 56-AlaProArgValVal-60 72-LeuGluHisSerLeuArgAsp-78 87-LeuIleAlaSerLeuAlaAspLeuTyrAlaLysLeu-98 lll-AlaLeuLeuAlaLysLeuAlaGlyArgProAlaGluAlaValAlaArgTyrArgGlu-129 172-ProValLeuGluAsnValGlyArgPheArgLysLysAlaGlu-185 375-LysArgLeuGlyGluSerAlaThrValPheGlyGlyTrpGlnPheVal-390 415-AlaGlyTrpAlaGlnGluTrpArgGlnLeuGlyGlyLeu-427 435-TyrAlaArgArgAsnTyr-440 Antigenic Index - Jameson-Wolf 27-AlaIleLeuAspAspLysAlaLeu-34 39-ArgSerValSerAspLysTrpAlaGluSerAspTrpLysValAspAsnAspAlaProArgValValAspGlyA spPhe-64 70-LysMetLeuGluHisSerLeuArgAspValLeuAsnGlyAsnGlnAlaAsp-86 97-LysLeuProAspTyrAspAla-103 108-ArgAlaArgAlaLeu-112 116-LeuAlaGlyArgProAlaGluAlaValAlaArgTyrArgGluLeuHisGlyGluAsnAlaAlaAspGluArg IleLeu-141 145-AlaAlaAlaGluPheAspAspPheArgLeuLysSerAlaGluArgHisPheAlaGluAlaGluLysLeuAsp Leu-169 176-AsnValGlyArgPheArgLysLysAlaGluGlyLeuThrGly-189 192-PheSerGlyGlyIle-196 199-AlaValAsnArgAsnAlaAsnAsnAlaAla-208 210-GlnTyrCysArgGlnAsnGlyGlyArgGln-219 224-SerArgAlaGluArgAlaAla-230 236-IleGluAlaGluLysLeuThrAla-243 253-ArgSerAsnIleGlyGlyThrSerTyr-261 263-PheSerLysLysSerAlaTyrAspAspGlyPheGlyArg-275 279-GlyTrpGlnTyrLysAsnAlaArgGlnThr-288 300-SerGlySerAspGlyPheAspAlaLysThrLysArgValAsnAsnArgArgLeuProProTyr-320 332-HisThrTyrArgProAsnProGlyTrp-340 347-GluHisTyrArgGlnArgTyrArgGluGlnAspArgAlaGluTyrAsnAsnGlyArgGlnAspGlyPheTyr -370 373-SerAlaLysArgLeuGlyGlu-379 392-PheValProLysArgGluThrVal-399 406-AlaAlaTyrArgArgAsnGlyValTyrAlaGly-416 425-GlyGlyLeuAsnSerArgValSerAlaSerTyrAlaArgArgAsnTyrLysGly-442 448-ThrGluAlaGlnArgAsnArgGluTrpAsn-457 463-SerHisAspLysLeuSerTyrLysGly-471 480-PheGlyArgThrGluSerAsnValProTyrAlaLysArgArgAsnSerGlu-496 501-AlaAspTrpArgPhe-505 Hydrophilic Regions - Hopp-Woods 27-AlaIleLeuAspAspLysAlaLeu-34 39-ArgSerValSerAspLysTrpAlaGluSerAspTrpLysValAspAsnAspAlaProArgValValAsp-61 70-LysMetLeuGluHisSerLeuArgAspValLeuAsn-81 108-ArgAlaArgAlaLeu-112 116-LeuAlaGlyArgProAlaGluAlaValAlaArgTyrArgGluLeuHisGly-132 134-AsnAlaAlaAspGluArgIleLeu-141 145-AlaAlaAlaGluPheAspAspPheArgLeuLysSerAlaGluArgHisPheAlaGluAlaGluLysLeuAsp Leu-169 176-AsnValGlyArgPheArgLysLysAlaGluGly-186 200-ValAsnArgAsnAlaAsn-205 212-CysArgGlnAsnGlyGlyArgGln-219 224-SerArgAlaGluArgAlaAla-230 236-IleGluAlaGluLysLeuThrAla-243 265-LysLysSerAlaTyrAspAspGlyPheGly-274 283-LysAsnAlaArgGlnThr-288 303-AspGlyPheAspAlaLysThrLysArgValAsnAsnArgArgLeuPro-318 348-HisTyrArgGlnArgTyrArgGluGlnAspArgAlaGluTyrAsnAsnGlyArgGlnAsp-367 373-SerAlaLysArgLeuGlyGlu-379 393-ValProLysArgGluThrVal-399 407-AlaTyrArgArgAsnGly-412 435-TyrAlaArgArgAsnTyrLys-441 449-GluAlaGlnArgAsnArgGluTrp-456 463-SerHisAspLysLeuSerTyr-469 480-PheGlyArgThrGluSer-485 489-TyrAlaLysArgArgAsnSerGlu-496 a936-l AMPHI Regions - AMPHI 8-ValArgThrLeuThrAla-13 22-GlyCysValSerAlaVal-27 100-GlnPheValGlyGlnIle-105 112-AlaGluGlyValTyrAsnTyrIleThrValAlaSerLeuProArgThrAlaGlyAspIleAlaGlyAsp-13 4 Antigenic Index - Jameson-Wolf l-MetLysProLysProHisThrValArg-9 33-ValGlyAlaLysSerAlaValAspArgArgThrThrGlyAlaGlnThrAspAspAsnValMet-53 56-ArgIleGluThrThrAlaArgSerTyrLeuArgGlnAsnAsnGlnThrLysGlyTyr-74 94-AlaThrGluGlyGluLysGlnPhe-101 106-AlaArgSerGluGlnAlaAla-112 124-LeuProArgThrAlaGlyAspIleAlaGlyAspThrTrpAsnThrSerLysValArgAla-143 149-SerProAlaThrGlnAlaArgValLys-157 172-ThrProGluGluGlnAlaGlnIleThr-180 Hydrophilic Regions - Hopp-Woods l-MetLysProLysProHisThr-7 37-SerAlaValAspArgArgThrThrGlyAlaGlnThrAspAspAsnValMet-53 56-ArgIleGluThrThrAla-61 68-AsnAsnGlnThrLysGlyTyr-74 94-AlaThrGluGlyGluLysGlnPhe-101 106-AlaArgSerGluGlnAlaAla-112 125-ProArgThrAlaGly-129 152-ThrGlnAlaArgValLys-157 172-ThrProGluGluGlnAlaGlnIle-179 a937 AMPHI Regions - AMPHI 6-LeuProAlaLeuProAlaIleLeuProLeuSerAla-17 232-LysGlnProAspArgLeuAsp-238 Antigenic Index - Jameson-Wolf 27-AspIleMetThrAspLysGlyLysTrpLysLeuGluThr-39 44-LeuAsnSerGluAsnAsnArgAlaGluLeu-53 71-ThrGluIleGlnGluAsnGlySerAsnThr-80 95-GlyAsnThrAspIleTyrGlySerGlySer-104 108-HisGluGluArgLysLeuAspGlyAsnGlyLysThrArgAsnLysArgMetSerAsp-126 135-PheLeuLysAspAspLysAsnProAla-143 151-ThrValTyrGluLysSerArgAsnLysAlaSerSerGlyLysSer-165 187-TyrArgIleAsnGlySerLysThrLeuSerSerAsnThrLysTyrLysAlaGly-204 217-AlaAsnAspArgIleSerLeuThrGlyGly-226 231-GlyLysGlnProAspArgLeuAspGlyLysLysGluSerAlaArgAsnThrSerThr-249 273-ValSerGlyGlnSerSerSerGluLeuLysPhe-283 Hydrophilic Regions - Hopp-Woods 27-AspIleMetThrAspLysGlyLysTrpLysLeu-37 47-GluAsnAsnArgAlaGluLeu-53 72-GluIleGlnGluAsnGlySerAsn-79 108-HisGluGluArgLysLeuAspGlyAsnGlyLysThrArgAsnLysArgMetSerAsp-126 135-PheLeuLysAspAspLysAsnPro-142 151-ThrValTyrGluLysSerArgAsnLysAlaSerSer-162 193-LysThrLeuSerSer-197 199-ThrLysTyrLysAla-203 217-AlaAsnAspArgIleSer-222 232-LysGlnProAspArgLeuAspGlyLysLysGluSerAlaArgAsn-246 277-SerSerSerGluLeuLysPhe-283 a939 AMPHI Regions - AMPHI 32-AlaThrValCysAla-36 90-AspGlnAspIleLeu-94 121-LysIleTyrArgGly-125 135-CysMetSerCysHisGly-140 151-SerGluIleGlnAlaTyrProArgLeuGlyGly-161 169-GluGlnMetAsnAlaTyrLys-175 185-GluAspIleAlaAsnArgMetSer-192 Antigenic Index - Jameson-Wolf 18-AlaSerProLysAlaAspValGluLysGlyLysGlnVal-30 40-AlaAlaAspGlyAsnSerGlyIle-47 66-IleGlyIleArgAspGlyLysArgThrHisGlySerAlaAlaVal-80 88-LeuSerAspGlnAspIle-93 102-LysGlnGlnProLysSerGlyGluAlaAsnProLysGluAsnProGluLeuGly-119 122-IleTyrArgGlyGlyLeuSerAspLysLysValPro-133 139-HisGlyProSerGlyAlaGlyMetProGlyGlyGlySerGluIleGlnAla-155 157-ProArgLeuGlyGlyGlnHisGln-164 172-AsnAlaTyrLysSerGlyGlnArgLysAsnThrIleMetGluAspIleAlaAsnArgMetSerGluGluAsp LeuLysAla-198 Hydrophilic Regions - Hopp-Woods 18-AlaSerProLysAlaAspValGluLysGlyLysGlnVal-30 40-AlaAlaAspGlyAsnSer-45 67-GlyIleArgAspGlyLysArgThrHisGly-76 89-SerAspGlnAspIle-93 103-GlnGlnProLysSerGlyGluAlaAsnProLysGluAsnProGluLeuGly-119 126-GlyLeuSerAspLysLysValPro-133 175-LysSerGlyGlnArgLysAsnThrIleMetGluAspIleAlaAsnArgMetSerGluGluAspLeuLysAla -198 a950 AMPHI Regions - AMPHI 33-GlyValHisLysSerAlaHisGly-40 71-AlaThrValLysLysThrHisLysHisThrLysAla-82 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnIle-5 23-AlaAlaAsnLysProAlaSerAsnAlaThrGlyValHisLysSerAlaHisGlySerCysGlyAlaSerLysS erAlaGluGlySerCysGlyAlaAlaGlySerLysAlaGlyGluGlyLysCysGlyGluGlyLysCysGlyAlaTh rValLysLysThrHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysGlyGluGly LysCysGlySerLys-102 Hydrophilic Regions - Hopp-Woods 23-AlaAlaAsnLysProAlaSer-29 33-GlyValHisLysSerAlaHis-39 43-GlyAlaSerLysSerAlaGluGlySerCys-52 55-AlaGlySerLysAlaGlyGluGlyLysCysGlyGluGlyLysCys-69 71-AlaThrValLysLysThrHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysG lyGluGlyLysCysGlySerLys-102 a951 AMPHI Regions - AMPHI 7-ThrIleLeuSerValLeuAlaAla-14 28-AspAlaLysProProLysGluValGlyLysValPheArgLysGlnGlnArgTyr-45 60-ValGlyGluArgValAsn-65 125-TrpArgGlnIleGluProIleProGlyLys-134 153-HisLeuAspGlyLeuGluGluValLeuAla-162 187-AlaGlnLysAlaSerLysAlaValArgArg-196 202-GluHisLeuProGluAlaAla-208 226-GlyAlaLeuGlnArgLeuAlaLysLeu-234 252-LysTyrProGluIleLeuAspGlyPhePheGlu-262 276-MetGluIleMetAsnLeuValSerLeuHisArgLeuAspAspAla-290 323-ValIleAspGlyTyrAlaGluLys-330 360-ValArgGlnTrpLeuLys-365 393-AlaLeuArgGlnIleGlyArgValArgLysLeuProGluGlnGln-407 414-AspAsnLeuSerLysIle-419 421-MetPheAlaLeuSer-425 432-GluAlaLeuArgGlyLeuAspLysIleIleGluLys-443 475-SerAspLeuGluArgAlaPheArg-482 493-AsnLeuGlyTyrSer-497 501-AspSerLysArgLeu-505 561-HisLeuGlyGluVal-565 577-AspValTrpThrGlnAla-582 592-TrpArgGluThrLeu-596 Antigenic Index - Jameson-Wolf 26-AlaAlaAspAlaLysProProLysGluValGlyLysValPheArgLysGlnGlnArgTyrSerGluGluGluI leLysAsnGluArgAlaArgLeu-57 59-AlaValGlyGluArgValAsn-65 75-ThrAlaLeuGlnLysGlyGlnAla-82 94-GluArgThrLysSerProGluValAlaGluArgAlaLeuGlu-107 124-LysTrpArgGlnIleGluProIleProGlyLysAlaGlnLysArgAlaGlyTrpLeuArgAsnValLeuArg GluArgGlyAsnGlnHisLeuAspGlyLeuGluGluValLeuAlaGlnAlaAspGluGlyGlnAsnArgArg-171 181-ValGlnGlnAspGlyLeuAlaGlnLysAlaSerLysAlaValArgArgAlaAlaLeuArg-200 217-GlnGlyArgGluLysGluLysAlaIle-225 230-ArgLeuAlaLysLeuAspThrGluIleLeuPro-240 248-LeuThrAlaArgLysTyrProGluIleLeuAspGlyPhePheGluGlnThrAspThrGlnAsn-268 285-HisArgLeuAspAspAlaTyrAla-292 298-LeuGluArgAsnProAsnAlaAsp-305 315-AlaAsnArgLysGluGlyAlaSer-322 326-GlyTyrAlaGluLysAlaTyrGlyArgGlyThrGlyGluGlnArgGlyArgAla-343 352-AlaAspArgArgAspTyrThrLysValArgGlnTrpLeuLysLysValSerAlaPro-370 373-LeuPheAspLysGlyVal-378 385-ValGluLeuAspGlyGlyArgAlaAlaLeu-394 396-GlnIleGlyArgValArgLysLeuProGluGlnGlnGlyArgTyrPheThr-412 426-LysLeuProAspLysArgGluAlaLeuArgGlyLeuAspLysIleIleGluLysProProAlaGlySerAsn ThrGluLeuGlnAla-454 466-ArgLeuGlyLysArgLysLysMetI1eSerAspLeuGluArgAlaPheArgLeuAlaProAspAsn-487 499-LeuSerAspSerLysArgLeuAspGluGlyPhe-509 518-IleAsnProAspAspThrAlaValAsnAspSerIle-529 535-LeuLysGlyAspAlaGluSerAla-542 547-ArgTyrSerPheGluAsnAspProGluProGluVal-558 570-GlyGluArgAspGlnAla-575 584-HisLeuThrGlyAspLysLysIleTrpArgGluThrLeuLysArgHisGlyIleAlaLeuProGlnProSer ArgLysProArgLys-612 Hydrophilic Regions - Hopp-Woods 26-AlaAlaAspAlaLysProProLysGluValGlyLysValPheArgLysGlnGlnArgTyrSerGluGluGluI leLysAsnGluArgAlaArgLeu-57 59-AlaValGlyGluArgValAsn-65 75-ThrAlaLeuGlnLysGlyGlnAla-82 94-GluArgThrLysSerProGluValAlaGluArgAlaLeuGlu-107 131-IleProGlyLysAlaGlnLysArgAlaGlyTrp-141 145-ValLeuArgGluArgGlyAsnGlnHis-153 155-AspGlyLeuGluGluValLeuAlaGlnAlaAspGluGlyGlnAsnArgArg-171 185-GlyLeuAlaGlnLysAlaSerLysAlaValArgArgAlaAlaLeuArg-200 217-GlnGlyArgGluLysGluLysAlaIle-225 230-ArgLeuAlaLysLeuAspThrGluIle-238 248-LeuThrAlaArgLysTyrProGluIle-256 261-PheGluGlnThrAspThrGlnAsn-268 285-HisArgLeuAspAspAlaTyrAla-292 298-LeuGluArgAsnProAsn-303 315-AlaAsnArgLysGluGlyAlaSer-322 327-TyrAlaGluLysAlaTyrGly-333 335-GlyThrGlyGluGlnArgGlyArgAla-343 352-AlaAspArgArgAspTyrThrLys-359 385-ValGluLeuAspGlyGlyArgAlaAlaLeu-394 396-GlnIleGlyArgValArgLysLeuProGluGlnGlnGly-408 426-LysLeuProAspLysArgGluAlaLeuArgGlyLeuAspLysIleIleGluLysProProAla-446 448-SerAsnThrGluLeuGlnAla-454 466-ArgLeuGlyLysArgLysLysMetIleSerAspLeuGluArgAlaPheArgLeuAlaProAspAsn-487 500-SerAspSerLysArgLeuAspGlu-507 519-AsnProAspAspThrAlaVal-525 537-GlyAspAlaGluSer-541 550-PheGluAsnAspProGluProGluVal-558 570-GlyGluArgAspGlnAla-575 586-ThrGlyAspLysLys11eTrpArgGluThrLeuLysArgHisGly-600 605-GlnProSerArgLysProArgLys-612 a952 AMPHI Regions - AMPHI 63-SerValAlaThrLeuLeuAsnAsnPheTyrGlyGln-74 81-ValLeuLysLysLeuAsp-86 94-PheGluAspMetArgArgIle-100 116-GluGlnLeuAlaGlnLeu-121 138-SerValLeuArgGlyIleAsp-144 Antigenic Index - Jameson-Wolf 40-GlnSerTrpLysGluArgArgAspPheAsnIleValLysGlnAspLeuAspPheSerCys-59 70-AsnPheTyrGlyGlnThrLeuThrGluGluGluValLeuLysLysLeuAspLysGluGlnMetArgAlaSerP heGluAspMetArgArgIleMetPro-102 104-LeuGlyPheGluAlaLysGlyTyr-lll 129-LeuLysTyrArgLysAspAspHisPheSer-138 141-ArgGlyIleAspGlyAsnThr-147 169-TrpGlnThrArgGluGlyAsnLeuAla-177 184-ValProLysLysAlaGluThrIleSer-192 199-HisHisProLysArgGlnThrGlu-206 213-ArgGlnAlaArgAlaGlu-218 Hydrophilic Regions - Hopp-Woods 41-SerTrpLysGluArgArgAspPheAsnIleValLysGlnAspLeuAspPhe-57 76-LeuThrGluGluGluValLeuLysLysLeuAspLysGluGlnMetArgAlaSerPheGluAspMetArgArgI leMetPro-102 104-LeuGlyPheGluAlaLysGly-110 130-LysTyrArgLysAspAspHisPheSer-138 169-TrpGlnThrArgGluGlyAsnLeu-176 184-ValProLysLysAlaGluThrIleSer-192 200-HisProLysArgGlnThrGlu-206 213-ArgGlnAlaArgAlaGlu-218 a953 AMPHI Regions - AMPHI 39-AsnThrSerThrAsnValGlyGlyPheTyrGlyLeuThr-51 75-GlnSerGlySerGlnHisPheThrAspHisLeuLysSerAlaAspIlePheAspAlaAlaGln-95 151-GlyAspPheSerThrThr-156 Antigenic Index - Jameson-Wolf 22-TyrLysValAspGluTyrHisAla-29 38-PheAsnThrSerThrAsnVal-44 54-ValGluPheAspGlnAlaLysArgAspGlyLysIleAspIle-67 83-AspHisLeuLysSer-87 95-GlnTyrProAspIleArgPheValSer-103 105-LysPheAsnPheAsnGlyLysLysLeuValSer-115 122-MetHisGlyLysThrAlaProValLysLeuLysAlaGluLys-135 137-AsnCysTyrGlnSerProMetLeuLys-145 147-GluValCysGlyGlyAsp-152 154-SerThrThrIleAspArgThrLysTrpGly-163 174-LysSerValArgIle-178 180-IleGlnIleGluAlaAlaLysGln-187 Hydrophilic Regions - Hopp-Woods 22-TyrLysValAspGluTyrHisAla-29 54-ValGluPheAspGlnAlaLysArgAspGlyLysIleAspIle-67 83-AspHisLeuLysSer-87 108-PheAsnGlyLysLysLeuValSer-115 125-LysThrAlaProValLysLeuLysAlaGluLys-135 155-ThrThr11eAspArgThrLysTrp-162 174-LysSerValArgIle-178 180-IleGlnIleGluAlaAlaLysGln-187 a957 AMPHI Regions - AMPHI H-SerPhePheAlaLeuValPheAla-18 45-AlaPheValAlaLysLeuAlaArgLeuPheArgAsnAla-57 71-GluGluSerLeuAlaGlyAlaValAspAsp-80 195-GluAspValTyrGluHisCysLeuGlyCysTyrGlnMet-207 215-TyrArgAspValAlaAsnAspGlu-222 232-SerAsnArgIleAlaSer-237 246-GlnAsnMetArgGluLeuMetProArg-254 352-GluLysGluValSerArgTyrAlaGluAlaAlaAlaArg-364 Antigenic Index - Jameson-Wolf 29-IleAsnProArgTrp-33 35-LeuSerAspThrAlaThrGluAsnProAsn-44 54-PheArgAsnAlaAspArgAla-60 64-ValLysGluSerMetArgThrGluGluSerLeu-74 77-AlaValAspAspGlyProLeuGlnSerGluLysAspTyr-89 95-ArgLeuSerArgLeuLysGluLysAlaLys-104 109-ThrGluGlnGluHisGlyGlu-115 122-TyrIleGlyGluGlyGly-127 133-LeuSerGlnArgSerProGluAlaPheVal-142 146-TyrLeuTyrArgAsnAspArgProPheSer-155 163-ValHisGlyGluAsnTyrGluThrThrGlyGluTyrArgVal-176 179-GlnProAspGlySerValPheAspAlaSerGlyArgGlyLysIleGlyGluAspValTyr-198 214-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgGluGluSerAsnArgIleAlaSer AspSerArgAspSerValPhe-244 247-AsnMetArgGluLeuMetProArgGlyMetLysAlaAsnSer-260 265-TyrAspAlaAspGlyLeuProGln-272 277-SerPheAspAsnGlyLysLysArgGlnSerPheGluTyrTyrLeuLysAsnGlyAsn-295 306-LeuLysAlaAspGlyValThr-312 326-LeuAspGlyGlyArgIleValArgGluGluLysGlnGlyAspArgLeuProAspPhe-344 346-LeuAsnLeuGluAspLeuGluLysGluValSerArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArg ArgAspLeuSerHis-374 Hydrophilic Regions - Hopp-Woods 38-ThrAlaThrGluAsnPro-43 54-PheArgAsnAlaAspArgAla-60 64-ValLysGluSerMetArgThrGluGluSerLeu-74 77-AlaValAspAspGlyProLeuGlnSerGluLysAspTyr-89 95-ArgLeuSerArgLeuLysGluLysAlaLys-104 109-ThrGluGlnGluHisGlyGlu-115 133-LeuSerGlnArgSerProGlu-139 148-TyrArgAsnAspArgProPhe-154 166-GluAsnTyrGluThrThrGlyGluTyr-174 187-AlaSerGlyArgGlyLysIleGlyGluAspValTyr-198 214-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgGluGluSerAsnArgIleAlaSer AspSerArgAspSerVal-243 247-AsnMetArgGluLeuMetProArgGlyMetLys-257 265-TyrAspAlaAspGlyLeuPro-271 279-AspAsnGlyLysLysArgGlnSer-286 306-LeuLysAlaAspGlyValThr-312 328-GlyGlyArgIleValArgGluGluLysGlnGlyAspArgLeuPro-342 346-LeuAsnLeuGluAspLeuGluLysGluValSerArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArg ArgAspLeuSerHis-374 a958 AMPHI Regions - AMPHI 39-GlyGlySerValArgSerValSerGluProIleGln-50 86-ProGluAspTyrThrArgIleValAlaAsp-95 127-TyrAspGlnSerGlyAsp-132 177-ArgArgLeuGlnSerValSerArgThrAlaGluMet-188 343-IleSerAspThrLeuGln-348 483-TyrTyrSerLeuAsnArgPhe-489 491-SerGlnGluAlaArgArgVal-497 500-ThrLeuProIleVal-504 541-GlnAsnAspLeuProAsnPheAsp-548 572-AsnThrAlaAsnSerLeuSerAlaAlaValGlnSer-583 693-AspLysLeuSerGln-697 723-LysLysProIleGlu-727 769-AspLeuSerSerValGlyArgAsnPro-777 Antigenic Index - Jameson-Wolf 18-PheGlyThrHisCys-22 28-ValAlaAlaGluGluThrAspAsnProThrAlaGlyGlySerValArgSerValSerGluProIleGln-50 55-SerLeuGlySerThr-59 63-CysSerAsnGluSerGlySerProGluArgThrGluAlaAlaValGlnGlySerGlyGluAlaSerIleProG luAspTyrThrArgIleValAlaAspArgMetGluGlyGlnSerGlnValGlnValArgAlaGluGly-109 Hl-ValValValGluArgAsnArgThrThrLeuAsn-121 123-AspTrpAlaAspTyrAspGlnSerGlyAspThrValThrAlaGlyAspArgPheAlaLeuGlnGlnAspGly ThrLeuIleArgGlyGluThrLeu-154 158-LeuGluGlnGlnThrGlyGluAlaHisAsnValArgMetGluThrGluHisGlyGlyArgArgLeuGlnSer ValSerArgThrAlaGluMetLeuGlyGluGlyHisTyrLysLeuThrGluThrGlnPheAsnThrCysSerAlaG lyAspAlaGlyTrp-211 216-AlaSerValGluAlaAspArgGluLysGlyIleGly-227 249-PheProLeuAspGlyAsnArgLysSerGlyLeu-259 265-SerAlaGlySerAspGlyVal-271 292-GlyValIleGlyGluArgGlyAlaValPheAspGlyGlnValArgTyrLeuArgProAspTyrAlaGlyGln SerAsp-317 321-LeuProHisAspLysLysSerGlyArgAsnAsnArgTyrGlnAla-335 337-TrpGlnHisArgHisAspIleSerAspThrLeu-347 352-AspPheAsnGlnValSerAspSerGlyTyrTyrArgAspPheTyrGlyAsnLysGluIleAlaGlyAsnVal AsnLeuAsnArgArgValTrp-382 384-AspTyrGlyGlyArgAlaAlaGlyGlySerLeu-394 407-AlaAsnGlnSerGlyTyrLysAspLysProTyr-417 422-ArgLeuSerAlaAspTrpArgLysAsnThrGlyArgAla-434 444-ArgPheSerHisAspSerArgGlnAspGlySerArg-455 460-ProAspIleLysTrpAspPheSerAsnSerTrpGly-471 487-AsnArgPheGlySerGlnGluAlaArgArgValSerArg-499 507-AspSerGlyMetThrPheGluArgAsnThrArgMetPheGlyGlyGly-522 525-GlnThrLeuGluProArg-530 538-AlaLysSerGlnAsnAspLeuProAsnPheAspSerSerGluSerSerPheGly-555 560-PheArgGluAsnLeuTyrTyrGlyAsnAspArgIleAsnThrAlaAsnSer-576 581-ValGlnSerArgIleLeuAspGlyAlaThrGlyGluGluArgPheArgAlaGlyIleGlyGlnLysPheTyr PheLysAsnAspAlaValMetLeuAspGlySerValGlyLysLysProArgSerArgSerAspTrp-626 631-SerSerGlyIleGlySerArgPheIleLeuAspSerSerIleHisTyrAsnGlnAsnAspLysArgAlaGlu Asn-655 660-AlaSerTyrArgProAlaGlnGlyLysValLeuAsnAlaArgTyrLysTyrGlyArgAsnGluLysIleTyr LeuLysSerAspGlySerTyrPhe-691 693-AspLysLeuSerGln-697 718-TyrGlyPheGluAlaLysLysProIleGlu-727 732-AlaGluTyrLysSerSerCysGlyCysTrp-741 751-ValThrGlyGluAsnThrTyrLysAsn-759 766-GlnLeuLysAspLeuSerSerValGlyArgAsnProAlaAspArgMetAspVal-783 Hydrophilic Regions - Hopp-Woods 28-ValAlaAlaGluGluThrAspAsnProThr-37 40-GlySerValArgSerValSerGluProIleGln-50 65-AsnGluSerGlySerProGluArgThrGluAlaAlaVal-77 79-GlySerGlyGluAlaSerIleProGluAspTyrThr-90 93-ValAlaAspArgMetGluGlyGlnSer-101 103-ValGlnValArgAlaGluGly-109 Hl-ValValValGluArgAsnArgThrThrLeu-120 125-AlaAspTyrAspGlnSerGlyAspThrValThrAlaGlyAspArgPheAlaLeu-142 147-ThrLeuIleArgGlyGluThr-153 160-GlnGlnThrGlyGluAlaHisAsnValArgMetGluThrGluHisGlyGlyArgArgLeuGlnSerValSer ArgThrAlaGluMetLeuGly-190 192-GlyHisTyrLysLeuThrGlu-198 216-AlaSerValGluAlaAspArgGluLysGlyIleGly-227 250-ProLeuAspGlyAsnArgLysSerGly-258 266-AlaGlySerAspGlyVal-271 294-IleGlyGluArgGlyAlaVal-300 305-ValArgTyrLeuArg-309 323-HisAspLysLysSerGlyArgAsnAsnArgTyrGlnAla-335 337-TrpGlnHisArgHisAspIleSerAsp-345 410-SerGlyTyrLysAspLysProTyr-417 423-LeuSerAlaAspTrpArgLysAsnThrGlyArgAla-434 445-PheSerHisAspSerArgGlnAspGlySerArg-455 490-GlySerGlnGluAlaArgArgValSerArg-499 510-MetThrPheGluArgAsnThrArg-517 539-LysSerGlnAsnAsp-543 548-AspSerSerGluSer-552 569-AspArg11eAsnThr-573 589-AlaThrGlyGluGluArgPheArgAla-597 615-SerValGlyLysLysProArgSerArgSerAsp-625 648-GlnAsnAspLysArgAlaGluAsn-655 662-TyrArgProAlaGln-666 674-TyrLysTyrGlyArgAsnGluLysIleTyrLeuLysSerAspGly-688 720-PheGluAlaLysLysProIleGlu-727 732-AlaGluTyrLysSer-736 766-GlnLeuLysAspLeuSerSerValGlyArgAsnProAlaAspArgMetAspVal-783 a959 AMPHI Regions - AMPHI 56-AlaAlaLeuAlaArgValGlyGly-63 Antigenic Index - Jameson-Wolf 24-AlaHisHisAspGlyHisGlyAspAspAspHisGlyHis-36 40-GlnHisSerLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAlaLeu-58 60-ArgValGlyGlyLysIleThrAspIleAspLeuGluHisAspAsnGlyArgProHisTyrAspValGluIleV alLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArgValIleSerSerArgArgAspAsp-108 Hydrophilic Regions - Hopp-Woods 27-AspGlyHisGlyAspAspAspHisGlyHis-36 40-GlnHisSerLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAlaLeu-58 61-ValGlyGlyLysIleThrAspIleAspLeuGluHisAspAsnGlyArgProHisTyr-79 82-GluIleValLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArg-100 102-IleSerSerArgArgAspAsp-108 a972 AMPHI Regions - AMPHI 15-SerSerGluArgMetSerGluValGluTyrPheSerHis-27 83-ArgLysLeuGluGluIleLeuGly-90 100-ArgGlyAsnLysPheTyrGluSerMetTyrArgLeu-111 154-LeuAspAspSerIleArg-159 226-PheValArgValTyrGluLysGly-233 275-IleCysArgLysPheLysAsnMetProValPro-285 308-AsnAlaValGlyLysLeuValAsnPhe-316 326-GluIleValGluSerLeuLysAla-333 336-GlyPheProLysGlyLeuGlu-342 348- euGluMe LeuArgAspGlyLeuLys-356 382-AsnSerAspLysPheAspArg-388 Antigenic Index - Jameson-Wolf l-LeuThrAsnArgGlyGlyAlaLysLeuLysThrAsnSerLysSerSerGluArgMetSerGlu-21 29-IleSerAspGlyLysGlyLysLeuLeuGluIleProGlnArgArgGlyLysGlnAspGlyVal-49 62-ThrLeuLeuLysValSerGly-68 83-ArgLysLeuGluGlu-87 93-IleThrArgLysCysLysSerArgGlyAsnLysPheTyrGlu-106 108-MetTyrArgLeuGlySerAspAspValAspTyrGly-119 122-HisPheGlyGlyGlnArgAsnThrVal-130 134-LeuLysGlyThrGlyCys-139 152-GlnPheLeuAspAspSerIleArgThrArgIleThrArg-164 172-PheAspGlyGluTyrThrProAspGlnAlaLeuLeuAspHisAspAsnGlyPhePheAspAsnSerAsnGln ArgProLysSerGluThrIleGly-203 205-AlaTrpArgAsnGluAspGlySerGlyLys-214 217-TyrValGlyArgLysLysAsnSerArgPhe-226 228-ArgValTyrGluLysGlyArgGlnLeuGlyAspLysGluSerLysTrpVal-244 251-AsnTyrGlyAspIleGluIle-257 263-IleAsnGlnGlySer-267 275-IleCysArgLysPheLysAsnMetProValProGluArgPheAspGlnArgLysLysThrLeu-295 321-GlyPheAspAsnSerGluIleValGluSerLeuLysAlaAspSerGlyPheProLysGlyLeuGluProGlu LysTyrAla-347 350-MetLeuArgAspGlyLeuLys-356 361-HisGluGlnProAspIleAspLeuGluIleGluLeuAspGlu-374 380-PheLysAsnSerAspLysPheAspArgGluLysArgLeuPheSerProAspTyrAspValGluLysGluArg LysTyrGlnGluTyrLeu-409 417-ValAspTyrAspTyrPhe-422 Hydrophilic Regions - Hopp-Woods l-LeuThrAsnArgGlyGlyAlaLysLeuLysThrAsnSerLysSerSerGluArgMetSerGlu-21 30-SerAspGlyLysGlyLysLeuLeuGluIleProGlnArgArgGlyLysGlnAspGlyVal-49 83-ArgLysLeuGluGlu-87 93-IleThrArgLysCysLysSerArgGlyAsnLysPheTyr-105 lll-LeuGlySerAspAspValAspTyrGly-119 134-LeuLysGlyThrGly-138 152-GlnPheLeuAspAspSerIleArgThrArgIleThrArg-164 181-AlaLeuLeuAspHisAspAsnGlyPhe-189 193-SerAsnGlnArgProLysSerGluThrIle-202 206-TrpArgAsnGluAspGlySerGly-213 219-GlyArgLysLysAsnSerArgPhe-226 228-ArgValTyrGluLysGlyArgGlnLeuGlyAspLysGluSerLysTrpVal-244 277-ArgLysPheLysAsn-281 283-ProValProGluArgPheAspGlnArgLysLysThrLeu-295 321-GlyPheAspAsnSerGluIleValGluSerLeuLysAlaAspSerGlyPhe-337 339-LysGlyLeuGluProGluLysTyrAla-347 350-MetLeuArgAspGlyLeuLys-356 362-GluGlnProAspIleAspLeuGluIleGluLeuAspGlu-374 381-LysAsnSerAspLysPheAspArgGluLysArgLeuPhe-393 396-AspTyrAspValGluLysGluArgLysTyrGlnGluTyrLeu-409 a973 AMPHI Regions - AMPHI 12-GluArgLeuIleAlaArgLeuAlaArgGluProAspSerAla-25 44-AspThrLeuLeuArgLeuGluLysValLeuAspPhe-55 77-AspSerIleGluArgIleThrAlaTyr-85 112-AspLeuLeuLysTyrMet-117 143-AlaLeuLeuLysGluPheArgGluGln-151 171-PheGluAspIleIleGluGlnIleValGlyAspIleGluAsp-184 208-AlaThrGluIleGluAspIleAsnAlaPhe-217 235-IleGlnGluLeuGly-239 Antigenic Index - Jameson-Wolf 1-MetAspGlyAlaGlnProLysThrAsnPhe-lO 18-LeuAlaArgGluProAspΞerAlaGluAsp-27 34-GlnAlaHisGluGlnGluValPheAspAlaAspThr-45 47-LeuArgLeuGluLysValLeuAsp-54 56-SerAspLeuGluValArgAspAlaMetIleThrArgSerArgMetAsnValLeuLysGluAsnAspSerIleG luArg-81 96-ValIleGlyGluAspLysAspGluVal-104 118-PheAsnProGluGlnPheHis-124 136-ProGluGlyLysSer-140 146-LysGluPheArgGluGlnArgAsnHis-154 159-IleAspGluTyrGlyGlyThrSerGly-167 178-IleValGlyAspIleGluAspGluPheAspGluAspGluSerAlaAspAsn-194 199-SerAlaGluArgTrpArg-204 209-ThrGluIleGluAsp-213 219-GlyThrGluTyrSerSerGluGluAlaAspThr-229 239-GlyHisLeuProValArgGlyGluLysValLeu-249 258-AlaArgAlaAspAsnArgArgLeuHis-266 Hydrophilic Regions - Hopp-Woods l-MetAspGlyAlaGlnProLys-7 18-LeuAlaArgGluProAspSerAlaGluAsp-27 34-GlnAlaHisGluGlnGluValPheAsp-42 47-LeuArgLeuGluLysValLeuAsp-54 56-SerAspLeuGluValArgAspAlaMetIleThrArgSerArgMetAsnValLeuLysGluAsnAspSerIleG luArg-81 96-ValIleGlyGluAspLysAspGluVal-104 136-ProGluGlyLysSer-140 146-LysGluPheArgGluGlnArgAsn-153 178-IleValGlyAspIleGluAspGluPheAspGluAspGluSerAlaAspAsn-194 199-SerAlaGluArgTrpArg-204 209-ThrGluIleGluAsp-213 222-TyrSerSerGluGluAlaAspThr-229 243-ValArgGlyGluLysValLeu-249 258-AlaArgAlaAspAsnArgArgLeuHis-266 a981 AMPHI Regions - AMPHI 31-AlaAsnProAspLysValTyrArgValAlaSer-41 46-AlaProPheGluSerLeuAsp-52 66-AsnAlaMetAlaLys-70 132-LysIleSerSerSerGluAspLeuLysAsnMetAsnLysValGlyValVal-148 167-LysIleAlaArgPheGlu-172 181-LeuGluAsnGlyGlyLeuAspSerValVal-190 197-AlaAsnTyrValLysAsnAsnPro-204 207-GlyMetAspPheValThrLeuPro-214 233-ValLysMetLeuAsnAspAlaLeuLysLysValArgGluSerGlyGluTyr-249 Antigenic Index - Jameson-Wolf 19-CysGlyGlyGlnGlyLysAspAlaAlaAla-28 31-AlaAsnProAspLysValTyrArg-38 49-GluSerLeuAspSerLysGlyAsnValGluGlyPheAsp-61 76-IleGluPheLysHisGlnProTrpAspSer-85 90-LeuAsnAsnGlyAspAlaAspVal-97 104-IleThrAspAspArgLysGlnSerMetAspPheSerAspProTyrPhe-119 127-ValProLysGlyLysLysIleSerSerSerGluAspLeuLysAsnMetAsnLys-144 160-LeuLeuGlyAsnAspAsnProLysIleAlaArg-170 179-LysGluLeuGluAsnGlyGlyLeuAspSerValValSerAspSerAla-194 201-LysAsnAsnProThrLysGlyMetAspPhe-210 214-ProAspPheThrThr-218 225-ValArgLysGlyAspGluAlaThrVal-233 235-MetLeuAsnAspAlaLeuLysLysValArgGluSerGlyGluTyrAspLysIleTyr-253 257-PheAlaLysGluAspGlyGlnAlaAlaLys-266 Hydrophilic Regions - Hopp-Woods 21-GlyGlnGlyLysAspAlaAlaAla-28 31-AlaAsnProAspLysValTyrArg-38 49-GluSerLeuAspSerLysGlyAsnValGluGlyPheAsp-61 91-AsnAsnGlyAspAlaAspVal-97 104-1leThrAspAspArgLysGlnSerMetAspPheSer-115 128-ProLysGlyLysLysIleSerSerSerGluAspLeuLysAsnMetAsn-143 164-AspAsnProLysIleAlaArg-170 179-LysGluLeuGluAsnGlyGlyLeu-186 203-AsnProThrLysGlyMetAsp-209 225-ValArgLysGlyAspGluAlaThrVal-233 235-MetLeuAsnAspAlaLeuLysLysValArgGluSerGlyGluTyrAspLysIleTyr-253 257-PheAlaLysGluAspGlyGlnAlaAlaLys-266 a982 AMPHI Regions - AMPHI 12-ValArgGlnLysMetValAsnGlyValAsnIleLeuAlaAsnAlaVal-27 71-AlaGlnMetValLysGluValAlaSerLysThr-81 100-ValAlaGluGlyMetLysTyr-106 115-AspLeuLysArgGlyIleAspLysAlaValAlaAlaLeuValGluGluLeuLysAsnIleAlaLysProCys AspThrSerLysGluIleAlaGlnValGlySer-149 160-AlaIleIleAlaGluAlaMetGluLysValGly-170 185-AsnGluLeuAspValValGluGlyMet-193 209-GluLysGlnIleAlaGlyLeuAsp-216 227-IleSerAsnIleArgAspLeuLeuProValLeuGluGlnValAlaLysAla-243 265-AsnAsnIleArgGlyIleLeuLysThrValAla-275 313-ThrLeuAspAspLeuGlyGlnAlaLysArgIle-323 331-ThrIleIleAspGlyPheGlyAspAlaAla-340 367-GluArgValAlaLysLeuAlaGlyGlyVal-376 426-LeuGluAsnLeuHisThr-431 444-LeuArgAlaValGluSerProLeuArgGlnIleValAlaAsnAla-458 484-GluTyrGlyAspMetIleGluMet-491 500-ThrArgSerAlaLeu-504 Antigenic Index - Jameson-Wolf l-MetAlaAlaLysAspValGlnPhe-8 10-AsnGluValArgGlnLysMetValAsn-18 30-ThrLeuGlyProLysGlyArgAsnValValVal-40 43-AlaPheGlyGlyProHisIleThrLysAspGlyValThrValAlaLysGluIleGluLeuLysAspLysPheG luAsnMetGly-70 73-Me ValLysGluValAlaSerLysThrAsnAspValAlaGlyAspGlyThrThr-90 112-AsnProThrAspLeuLysArgGlyIleAspLysAlaVal-124 129-GluGluLeuLysAsnIleAlaLysProCysAspThrSerLysGluIleAla-145 150-IleSerAlaAsnSerAspGluGlnVal-158 164-GluAlaMetGluLysValGlyLysGluGlyValIleThrValGluAspGlyLysSerLeuGluAsnGluLeu AspVal-189 193-MetGlnPheAspArgGlyTyr-199 207-AspAlaGluLysGlnIleAla-213 223-PheAspLysLysIleSerAsnIleArgAsp-232 239-GlnValAlaLysAlaSerArg-245 252-GluAspValGluGlyGluAla-258 266-AsnIleArgGlyIleLeu-271 278-AlaProGlyPheGlyAspArgArgLysAlaMetLeu-289 301-IleSerGluGluValGlyLeuSerLeuGluLysAlaThrLeuAspAspLeuGlyGlnAlaLysArgIleGlu IleGlyLysGluAsnThrThr-331 334-AspGlyPheGlyAspAlaAlaGlnIleGluAlaArgValAlaGluIleArgGlnGlnIleGluThrAlaThr SerAspTyrAspLysGluLysLeuGlnGluArgValAlaLysLeuAlaGly-374 385-ThrGluValGluMetLysGluLysLysAspArgValGluAspAlaLeuHis-401 405-AlaAlaValGluGluGlyVal-411 421-ArgAlaArgAlaAlaLeu-426 429-LeuHisThrGlyAsnAlaAspGlnAspAlaGlyVal-440 446-AlaValGluSerProLeuArg-452 457-AsnAlaGlyGlyGluProSerVal-464 469-ValLeuGluGlyLysGlyAsnTyrGlyTyr-478 480-AlaGlySerGlyGluTyrGlyAspMetIleGlu-490 495-AspProAlaLysValThrArgSerAlaLeu-504 523-GluIleProGluAspLysProAlaMetProAspMetGlyGly-536 Hydrophilic Regions - Hopp-Woods l-Me AlaAlaLysAspValGlnPhe-8 10-AsnGluValArgGlnLysMet-16 33-ProLysGlyArgAsnValValVal-40 48-HisIleThrLysAspGlyValThrValAlaLysGluIleGluLeuLysAspLysPheGluAsn-68 73-MetValLysGluValAlaSerLysThrAsnAspValAlaGlyAspGlyThrThr-90 114-ThrAspLeuLysArgGlyIleAspLysAlaVal-124 129-GluGluLeuLysAsnIleAlaLysProCysAspThrSerLysGluIleAla-145 152-AlaAsnSerAspGluGlnVal-158 164-GluAlaMetGluLysValGlyLysGluGlyValIleThrValGluAspGlyLysSerLeuGluAsnGluLeu AspVal-189 207-AspAlaGluLysGlnIleAla-213 223-PheAspLysLysIleSerAsnIleArgAsp-232 239-GlnValAlaLysAlaSerArg-245 252-GluAspValGluGlyGluAla-258 280-GlyPheGlyAspArgArgLysAlaMetLeu-289 301-IleSerGluGluValGlyLeuSerLeuGluLysAlaThrLeuAspAspLeuGlyGlnAlaLysArgIleGlu IleGlyLysGluAsnThrThr-331 340-AlaGlnIleGluAlaArgValAlaGluIleArgGlnGlnIleGluThrAlaThrSerAspTyrAspLysGlu LysLeuGlnGluArgValAlaLys-371 385-ThrGluValGluMetLysGluLysLysAspArgValGluAspAlaLeuHis-401 405-AlaAlaValGluGluGlyVal-411 421-ArgAlaArgAlaAlaLeu-426 432-GlyAsnAlaAspGlnAspAla-438 446-AlaValGluSerProLeu-451 458-AlaGlyGlyGluPro-462 469-ValLeuGluGlyLysGly-474 481-GlySerGlyGluTyrGlyAsp-487 495-AspProAlaLysValThrArg-501 523-GluIleProGluAspLysProAlaMet-531 a986 AMPHI Regions - AMPHI 6-GlnTyrLeuAlaLeuAla-ll 18-LeuAlaGlyCysAspLysAlaGly-25 36-SerPheValGluArgIleLysHis-43 52-MetLeuLeuProAspPheValGlnLeuVal-61 97-AspProPheTyrGluPhePheLysArgLeuValProAsnMetProGluIleProGln-115 145-ThrGlyMetGlySerIle-150 162-AlaLysLeuIleGlySerAspVal-169 189-IleGlyAsnProLysAspLeuLysProGly-198 200-TrpValAlaAlaIleGly-205 287-AlaGluGlnLeuLysAsnThrGlyLysVal-296 393-AlaAlaGluHisIleGlyAlaSer-400 471-ArgLysAlaMetAspLysAla-477 Antigenic Index - Jameson-Wolf l-ValPheLysLysTyr-5 20-GlyCysAspLysAlaGly-25 29-GlyAlaAspLysLysGluAlaSerPheValGluArgIleLysHisThrLysAspAspGlySerVal-50 61-ValGlnSerGluGlyProAla-67 75-ProAlaProArgThrGlnAsnGlySerSerAsnAlaGluThrAspSerAspProLeuAlaAspSerAspProP he-99 104-LysArgLeuValProAsnMetProGluIleProGlnGluGluAlaAspAspGlyGlyLeu-123 130-IleIleSerLysAspGlyTyr-136 154-LeuAsnAspLysArgGluTyrThr-161 165-IleGlySerAspValGlnSerAspValAla-174 179-AspAlaThrGluGluLeuPro-185 189-IleGlyAsnProLysAspLeuLysProGlyGlu-199 208-PheGlyPheAspAsnSerValThr-215 218-XxxValSerAlaLysGlyArgSerLeuProAsnGluSerTyr-231 242-AsnProGlyAsnSerGlyGlyPro-249 265-TyrSerArgSerGlyGly-270 288-GluGlnLeuLysAsnThrGlyLysValGlnArgGlyGlnLeu-301 316-PheGlyLeuAspLysAlaGlyGly-323 330-LeuProGlySerProAlaGluArgAlaGlyLeuArgAlaGlyAsp-344 349-LeuAspGlyGlyGluIleArgSerSerGlyAspLeu-360 368-ThrProGlyLysGluValSer-374 378-TrpArgLysGlyGluGluIleThrIle-386 397-IleGlyAlaSerSerLysThrAspGluAlaProTyrThrGluGlnGlnSerGlyThrPhe-416 427-ThrHisThrAspSerSerGlyGly-434 440-ArgValSerAspAlaAlaGluArgAlaGlyLeuArgArgGlyAspGluIleLeu-457 463-ProValAsnAspGluAlaGlyPheArgLysAlaMetAspLysAlaGlyLysAsnVal-481 486-MetArgArgGlyAsnThr-491 Hydrophilic Regions - Hopp-Woods 20-GlyCysAspLysAlaGly-25 29-GlyAlaAspLysLysGluAlaSerPheValGluArgIleLysHisThrLysAspAspGlySer-49 75-ProAlaProArgThrGlnAsnGlySerSerAsnAlaGluThrAspSerAspProLeuAlaAspSerAspPro- 98 lll-ProGluIleProGlnGluGluAlaAspAspGlyGly-122 131-IleSerLysAspGly-135 154-LeuAsnAspLysArgGluTyrThr-161 179-AspAlaThrGluGluLeuPro-185 190-GlyAsnProLysAspLeuLysPro-197 219-ValSerAlaLysGlyArgSerLeuPro-227 288-GluGlnLeuLysAsnThrGlyLysValGlnArgGlyGln-300 317-GlyLeuAspLysAlaGly-322 333-SerProAlaGluArgAlaGlyLeuArgAlaGlyAsp-344 350-AspGlyGlyGluIleArgSerSerGlyAsp-359 368-ThrProGlyLysGluValSer-374 379-ArgLysGlyGluGluIleThrIle-386 397-IleGlyAlaSerSerLysThrAspGluAlaProTyrThrGluGlnGlnSer-413 428-HisThrAspSerSerGly-433 440-ArgValSerAspAlaAlaGluArgAlaGlyLeuArgArgGlyAspGluIleLeu-457 463-ProValAsnAspGluAlaGlyPheArgLysAlaMetAspLysAlaGlyLys-479 a987 AMPHI Regions - AMPHI 17-CysSerSerTrpLeu-21 33-PheAsnThrSerLysProValArgLeuAspAsnIleLeuGlnIle-47 65-ProHisGluAlaPhe-69 144-AsnProPheValLeuArgLysTrpArgAlaLeuGlyTyrLeuThrAspPheProArgLeuAsnArg-165 187-GlyAspGluTyrPheLysVal-193 202-LeuAspIleLeuAlaThr-207 211-ValGlyGluValSerHisAspPheAspArgTyrTrpAla-223 230-AlaThrArgIleIleArgSerGly-237 239-IleGlyLysGlyLeuGlnAla-245 289-SerAspAspProAlaLysGlyLeuAspArg-298 307-GlyArgLeuGlnAspAlaLeuLysGlnPro-316 333-GlyThrAspAlaLeuAlaLysLeuValGlnAsp-343 355-GlnAlaThrAspValAlaAla-361 443-LysIleAlaGluGlnMetGluArgThrLeuAlaAspThr-455 486-ProGluAlaLysLeuTrpLysArgIleAlaAlaLysIleLeuSerLeuLeuProIleGluSerLeu-507 Antigenic Index - Jameson-Wolf 1-MetLysThrArgSer-5 23-ProLeuGluGluArgThrGluSerArgHisPheAsnThrSerLysProValArgLeu-41 49-HisThrProHisThrAsnGlyLeuSer-57 77-GluSerAlaGluHisSerLeu-83 90-TrpArgAsnAspIleSerGlyArgLeu-98 107-AlaGluArgGlyValArg-112 115-LeuLeuLeuAspAspAsnAsnThrArgGlyLeuAsp-126 134-SerHisProAsnIleGluValArgLeu-142 159-AspPheProArgLeuAsnArgArgMetHisAsnLysSerPheThrAlaAspAsnArgAla-178 182-GlyGlyArgAsnIleGlyAspGluTyrPheLysValGlyGluAspThrVal-198 214-ValSerHisAspPheAspArgTyrTrp-222 225-HisSerAlaHisAsn-229 232-ArgIleIleArgSerGlyAsnIleGlyLysGlyLeu-243 247-GlyTyrAsnAspGluThrSerArg-254 259-ArgTyrArgGluThrValGlu-265 267-SerProLeuTyrGln-271 273-IleGlnThrGlyArgIleAsp-279 287-LeuIleSerAspAspProAlaLysGlyLeuAspArgAspArgArgLysProProIle-305 308-ArgLeuGlnAspAlaLeuLysGlnProGluLysSer-319 328-ValProThrLysSerGlyThrAspAlaLeu-337 340-LeuValGlnAspGlyIleAsp-346 367-ValLysTyrArgLysProLeuLeu-374 391-AlaThrLysAspLysGlyLeuThrGlySerSer-401 412-ValAspGlyLysArgIlePhe-418 422-PheAsnLeuAspProArgSerAlaArgLeuAsnThr-433 440-GluSerProLysIleAlaGluGlnMetGluArgThrLeuAlaAspThrSerProGluTyrAla-460 463-ValThrLeuAspArgHisAsnArgLeuGlnTrpHisAspProAlaThrArgLysThrTyrProAsnGluPro GluAlaLysLeuTrpLys-492 Hydrophilic Regions - Hopp-Woods 1-MetLysThrArgSer-5 24-LeuGluGluArgThrGluSerArgHisPheAsnThr-35 37-LysProValArgLeu-41 77-GluSerAlaGluHisSerLeu-83 107-AlaGluArgGlyValArg-112 115-LeuLeuLeuAspAspAsnAsnThrArgGlyLeuAsp-126 161-ProArgLeuAsnArgArgMetHisAsn-169 172-PheThrAlaAspAsnArgAla-178 189-GluTyrPheLysValGlyGluAspThrVal-198 214-ValSerHisAspPheAspArg-220 248-TyrAsnAspGluThrSerArg-254 259-ArgTyrArgGluThrValGlu-265 274-GlnThrGlyArgIleAsp-279 287-LeuIleSerAspAspProAlaLysGlyLeuAspArgAspArgArgLysProProIle-305 308-ArgLeuGlnAspAlaLeuLysGlnProGluLysSer-319 331-LysSerGlyThrAspAlaLeu-337 340-LeuValGlnAspGlyIleAsp-346 367-ValLysTyrArgLysProLeuLeu-374 391-AlaThrLysAspLysGlyLeuThr-398 424-LeuAspProArgSerAlaArgLeuAsnThr-433 440-GluSerProLysIleAlaGluGlnMetGluArgThrLeuAlaAspThrSerPro-457 464-ThrLeuAspArgHisAsnArg-470 476-ProAlaThrArgLysThrTyrProAsnGluProGluAlaLysLeuTrpLys-492 a988 AMPHI Regions - AMPHI 45-SerLysIleGluAlaLeu-50 66-ArgArgLeuLysAlaMet-71 125-GlnMetArgGlyIle-129 154-AspIleValGluArgAlaGlnSerLysVal-163 221-AlaLysIleIleGluValLeuGlyAspTyrAlaAsp-232 248-HisGlnPheSerGluAlaCysAlaLysAlaAlaLysLysIleProAspHisValArgLys-267 288-ThrAlaArgAspPheAspAsp-294 299-GluLysIleGlyArgAsnTyrArg-306 310-AlaIleAlaAspValSerHisTyrValArgProAspAsp-322 348-AsnLeuSerAsnGly-352 396-AsnGlnValTrpLysTrpLeuSer-403 405-GlyIleGluHisPro-409 411-LysThrGlnIleAspThrLeuTyrLysLeuPheLysIleLeuGlnLys-426 494-LeuGlyProThrProGluLysLeuAlaAlaLeu-504 524-LysAspTyrAlaAlaLeuAla-530 544-ValMetMetLeuArgSerMetGlnGlnAla-553 569-AlaTyrAlaHisPheThrSerProIleArgArgTyrProAspLeuThrValHisArgAlaIleLysAlaVal Leu-593 619-AspAspAlaSerArgAspValGluAsnTrpLeuLys-630 646-IleSerGlyMetThrSerPheGlyIlePheValThrLeu-658 662-HisIleAspGlyLeuValHisIleSerAspLeuGlyGlu-674 Antigenic Index - Jameson-Wolf 1-Me AsnLysAsnl1eLys-6 8-LeuAsnLeuArgGluLysAspProPheLeuSerArgGluLysGlnArgTyrGluHisProLeuProSerArgGl uTrpIle-34 37-LeuLeuGluArgLysGlyValProSerLysIleGluAlaLeuValArg-52 54-LeuΞerIleLysGluGluGluTyrGluPhePheGluArgArgLeuLysAlaMetAlaArgAspGlyGln-76 79-IleAsnArgArgGlyAlaVal-85 87-AlaAlaAspLysLeuAspLeuValLysCysArgValLysAlaHisLysAspArgPheGlyPhe-107 lll-LeuThrProAlaLysAspGlyAsp-118 124-ArgGlnMetArgGly-128 140-AlaGlyMetAspGlyArgGlyArgArgGluGlyThrVal-152 155-IleValGluArgAlaGlnSerLysValValGly-165 167-PheXxxMetAspArgGlyValAla-174 176-LeuGluProGluAspLysArgLeuAsnGln-185 189-LeuGluProAspGlyValAlaArgPheLysProGluSerGlyGln-203 210-GluValTyrProGluGlnAsnArgProAlaVal-220 227-LeuGlyAspTyrAlaAspSerGlyMetGluIle-237 239-IleAlaValArgLysHisHisLeu-246 253-AlaCysAlaLysAlaAlaLysLysIleProAspHisValArgLysSerAspLeuLysGlyArgValAspLeu ArgAsp-278 283-ThrIleAspGlyGluThrAlaArgAspPheAspAsp-294 299-GluLysIleGlyArgAsnTyrArg-306 316-HisTyrValArgProAspAspAlaIleAspThrAspAlaGlnGluArgSerThrSerVal-335 337-PheProArgArgVal-341 345-LeuProGluAsnLeuSerAsnGly-352 374-AlaGlyAsnIleLysGluTyrArgPhe-382 402-LeuSerGlyGlyIleGluHisProPheLysThrGlnIle-414 424-LeuGlnLysLysArgPheGluArgGlyAlaValGluPheAspSerIleGlu-440 443-MetLeuPheAspAspAsnGlyLysIleGluLys-453 458-ValArgAsnAspAlaHisLysLeuIleGlu-467 482-LeuLysAsnLysHisThrAla-488 493-HisLeuGlyProThrProGluLysLeuAlaAlaLeuArgGluGlnLeu-508 516-GlyGlyGlyAspAsnProSerProLysAspTyrAla-527 532-GlnPheLysGlyArgProAspAlaGluLeu-541 556-GluProHisCysAspGlyHis-562 575-SerProIleArgArgTyrProAspLeuThrVal-585 597-ThrTyrThrProLysLysSerTrp-604 613-PheCysGluArgArgAlaAspAspAlaSerArgAspValGluAsn-627 633-TyrMetArgAspLysValGlyGluValPheGluGlyLysIleSerGly-648 670-SerAspLeuGlyGluAspTyrPheAsnPheArgPro-681 683-IleMetAlaIleGluGlyGluArgSerGlyIleArgPheAsnMetGlyAspArgValAlaValArgValAla ArgAlaAspLeuAspAspGlyLysIle-715 722-GlyGlySerGlyArgGlyArgLysValLysSerSerAlaSerAlaLysProAlaGlyThrAlaGlyLysGly LysProLysThrAlaAlaGluLysLysThrAlaArgGlyGlyLysValArgGlyArgGlyAlaSerAlaAlaAlaG luSerArgLysLysAlaLysLysProValProIleLysValLysLysArgLysGlyLysSer-791 Hydrophilic Regions - Hopp-Woods l-MetAsnLysAsnIleLys-6 8-LeuAsnLeuArgGluLysAspProPheLeuSerArgGluLysGlnArgTyrGluHis-26 37-LeuLeuGluArgLysGlyValProSerLysIleGluAlaLeuValArg-52 54-LeuSerIleLysGluGluGluTyrGluPhePheGluArgArgLeuLysAlaMetAlaArgAspGlyGln-76 79-IleAsnArgArgGlyAla-84 87-AlaAlaAspLysLeuAspLeuValLysCysArgValLysAlaHisLysAspArgPhe-105 113-ProAlaLysAspGlyAsp-118 140-AlaGlyMetAspGlyArgGlyArgArgGluGlyThrVal-152 155-IleValGluArgAlaGlnSerLysValValGly-165 167-PheXxxMetAspArgGlyValAla-174 176-LeuGluProGluAspLysArgLeuAsn-184 189-LeuGluProAspGlyValAlaArgPheLysProGluSerGly-202 210-GluValTyrProGluGlnAsnArgProAlaVal-220 230-TyrAlaAspSerGlyMetGluIle-237 239-IleAlaValArgLysHisHis-245 253-AlaCysAlaLysAlaAlaLysLysIleProAspHisValArgLysSerAspLeuLysGlyArgValAspLeu ArgAsp-278 284-1leAspGlyGluThrAlaArgAspPheAspAsp-294 300-LysIleGlyArgAsnTyr-305 318-ValArgProAspAspAlaIleAspThrAspAlaGlnGluArgSerThr-333 376-AsnIleLysGluTyrArg-381 424-LeuGlnLysLysArgPheGluArgGlyAlaValGluPheAspSerIleGlu-440 443-MetLeuPheAspAspAsnGlyLysIleGluLys-453 458-ValArgAsnAspAlaHisLysLeuIleGlu-467 496-ProThrProGluLysLeuAlaAlaLeuArgGluGlnLeu-508 517-GlyGlyAspAsnProSerProLysAspTyrAla-527 533-PheLysGlyArgProAspAlaGluLeu-541 576-ProIleArgArgTyrProAsp-582 598-TyrThrProLysLysSerTrp-604 613-PheCysGluArgArgAlaAspAspAlaSerArgAspValGluAsn-627 633-TyrMetArgAspLysValGlyGluValPheGluGlyLysIle-646 683-IleMetAlaIleGluGlyGluArgSerGlyIle-693 696-AεnMetGlyAspArgValAlaValArgValAlaArgAlaAspLeuAspAspGlyLysIle-715 723-GlySerGlyArgGlyArgLysValLysSerSerAlaSerAlaLysProAlaGlyThrAlaGlyLysGlyLys ProLysThrAlaAlaGluLysLysThrAlaArgGlyGlyLysValArgGlyArgGlyAlaSerAlaAlaAlaGluS erArgLysLysAlaLysLysProValProIleLysValLysLysArgLyεGlyLysSer-791 a989 AMPHI Regions - AMPHI 58-AlaGlyLeuThrLysLeu-63 85-SerAlaThrAspPhe-89 98-LysSerGlyLysIleThr-103 109-ProHisIleTyrGlyAla-114 183-GluLeuArgLysTyrAlaAspTrpGlyIleMetGluLysAlaLysAlaLeu-199 201-GluThrProProAsnProThrLysAla-209 299-SerValHisGlyMetTyrLysValSer-307 318-TrpThrArgHisSerArg-323 362-SerTyrGlnIleSerGluProLeu-369 448-PheLysAsnHisAlaAsp-453 Antigenic Index - Jameson-Wolf 43-AlaAlaAlaGluAlaAlaAspAlaSer-51 57-ProAlaGlyLeuThrLysLeuAspSerSerGlnIleSer-69 81-TyrGluAlaAspSerAlaThrAspPheThr-90 94-ValGlnGlySerLysSerGlyLysIleThrLysThrThr-106 116-LysValAsnAspAsnLeuThr-122 132-GlySerAlaThrGluTyrGluLysAspSerValLeu-143 146-AsnIleAεnLysLeuGly-151 164-LysLeuAsnGluArgHisSerPheGly-172 180-ThrSerAlaGluLeuArgLysTyrAla-188 194-GluLysAlaLysAlaLeuLysGluThrProProAsnProThrLysAlaAlaGlnIleLysAlaAspGlyHis AlaAspValLysGlySerAspTrpGly-226 236-AspIleAsnAspArgAlaArgValGlyValAsnTyrArgSerLysValSerHisThrLeuLysGlyAspAla GluTrpAlaAla-263 272-TrpAspAlaAsnLys-276 283-ThrProSerGluLysAlaArgValLysIleValThrProGluSer-297 304-TyrLysValSerAspLysAlaAspLeu-312 317-ThrTrpThrArgHisSerArgPheAεpLysAlaGluLeuValPheGluLysGluLysThrIleValAsnGly LysSerAspArgThrThrIle-347 349-ProAsnTrpArgAsnThrTyrLysValGlyPhe-359 361-GlySerTyrGlnIleSerGluLeuGln-370 375-IleAlaPheAspLysSerProValArgAsnAlaAspTyrArgMetAsnSerLeuProAspGlyAsn-396 407-HisIleGlyLysAsnHisVal-413 424-AsnAspThrSerTyrArgThrAlaLysAlaSerGlyAsnAspValAspSerLysGlyAlaSerSerAlaArg PheLysAsnHisAla-452 Hydrophilic Regions - Hopp-Woods 43-AlaAlaAlaGluAlaAlaAsp-49 61-ThrLysLeuAspSerSerGln-67 81-TyrGluAlaAspSerAlaThr-87 95-GlnGlySerLysSerGlyLysIleThrLys-104 135-ThrGluTyrGluLysAspSerValLeu-143 164-LysLeuAsnGluArgHisSer-170 180-ThrSerAlaGluLeuArgLysTyrAla-188 194-GluLysAlaLysAlaLeuLysGluThrProProAsnProThrLysAlaAlaGlnIleLysAlaAspGlyHis AlaAspValLysGlySerAsp-224 237-IleAsnAspArgAlaArgVal-243 247-TyrArgSerLysVal-251 255-LeuLysGlyAspAlaGluTrpAlaAla-263 284-ProSerGluLysAlaArgValLysIleValThr-294 305-LysValSerAspLyεAlaAspLeu-312 322-SerArgPheAspLysAlaGluLeuValPheGluLysGluLysThrIleVal-338 340-GlyLysSerAspArgThrThrIle-347 375-IleAlaPheAspLysSerProValArgAsnAlaAspTyrArgMet-389 391-SerLeuProAspGlyAsn-396 426-ThrSerTyrArgThrAlaLysAlaSerGlyAsnAspValAspSerLysGlyAlaSerSerAlaArgPheLys AsnHisAla-452 a990 AMPHI Regions - AMPHI 76-11eThrAspThrTyrGlyAspAsnLeuLysAspAlaValLysLysGlnLeuGlnAspLeuTyrLys-97 131-AspLeuIleAsnLysLeuVal-137 151-ThrSerLeuAsnAsnIlePhe-157 195-AspIleHisMetLeu-199 260-ProGluAsnLeuLysThrLeuAspGly-268 293-TyrGluLeuLeuLeuLysGlnCys-300 419-SerTyrLeuHisGlyTyrGlyGlyGlyValTyrAlaAlaTrp-432 442-AlaTyrLeuAspGlyTrpLeuGlnTyr-450 472-ThrAlaSerValGluGlyGlyTyrAsnAlaLeu-482 550-GlnProPheAlaAlaPheAsnValLeuHisArg-560 Antigenic Index - Jameson-Wolf 6-LeuGlySerAsnThrArgSerThrLysIleGlyAspAspAlaAεpPheSerPheSerAspLysProLysProGl yThr-31 35-PheSerSerGlyLysThrAspGlnAsnSerSerGluTyrGlyTyrAspGluIleAsnIleGlnGlyLysAsnT yrAsnSerGlyIle-63 75-TyrIleThrAspThrTyrGlyAspAεnLeuLysAspAlaValLysLysGlnLeuGlnAspLeuTyrLysThrA rgProGluAlaTrpGluGluAsnLysLysArgThrGluGluAlaTyr-114 123-SerIleLeuLysGlnLysAsnProAspLeuIle-133 145-HisSerAsnThrSerGlnThrSer-152 157-PheAεnLysLysLeuHisValLysIleGluAsnLysSerHisVal-171 179-ThrLysMetThrLeuLysAspSerLeuTrpGluProArgArgHisSerAspIleHisMet-198 200-GluThrSerAspAsnAlaArgIleArgLeuAsnThrLyεAεpGluLysLeuThrVal-218 222-TyrGlnGlyGlyAla-226 233-AspValArgGluSerAspLysProAlaLeuThrPheGluGluLysValSerGlyGlnΞerGlyValValLeu GluArgArgProGluAsnLeuLysThrLeuAspGlyArgLysLeuIleAlaAlaGluLysAlaAspSerAsnSerP heAlaPheLysGlnAsnTyrArgGlnGlyLeu-292 298-LysGlnCysGluGlyGlyPhe-304 312-AlaIleProGluAlaGlu-317 335-ArgAlaAlaAspArgGlyAspAspValTyrAlaAlaAspProSerArgGlnLysLeu-353 358-IleGlyGlyArgSerHisGlnAsnIleArgGlyGlyAlaAlaAlaAspGlyArgArgLysGlyVal-379 385-ValPheValArgGlnAsnGluGlySerArgLeuAla-396 400-MetGlyGlyArgAlaGlyGln-406 408-AlaSerValAsnGlyLysGlyGlyAla-416 435-LeuArgAspLysGlnThrGlyAlaTyr-443 452-ArgPheLysHisArgIleAεnAspGluAsnArgAlaGluArgTyrLysThrLysGlyTrpThr-472 475-ValGluGlyGlyTyr-479 487-ValValGlyLysGlyAsnAsnValArg-495 510-AsnGlyGlyPheThrAspSerGluGlyThrAla-520 525-GlySerGlyGlnTrpGlnSerArgAlaGlyIleArgAlaLysThrArgPheAlaLeuArgAsnGlyValAsn -548 559-HisArgSerLysSerPheGlyValGluMetAspGlyGluLysGlnThrLeuAla-576 579-ThrAlaLeuGluGlyArgPheGlyIle-587 589-AlaGlyTrpLysGlyHisMet-595 600-GlyTyrGlyLysArgThrAεpGlyAspLysGluAlaAlaLeu-613 Hydrophilic Regions - Hopp-Woods 8-SerAsnThrArgSerThrLysIleGlyAspAspAlaAspPheSerPheSerAspLysProLysProGlyThr-3 1 38-GlyLysThrAspGlnAsnSerSer-45 79-ThrTyrGlyAspAsnLeuLysAspAlaValLysLysGlnLeuGlnAsp-94 96-TyrLysThrArgProGluAlaTrpGluGluAsnLysLysArgThrGluGluAlaTyr-114 123-SerIleLeuLysGlnLysAsnProAspLeuIle-133 161-LeuHisValLysIleGluAsnLysSerHisVal-171 179-ThrLysMetThrLeuLys-184 186-SerLeuTrpGluProArgArgHisSerAsp-195 200-GluThrSerAspAsnAlaArgIleArgLeuAsnThrLysAspGluLysLeuThrVal-218 233-AspValArgGluSerAspLysProAlaLeuThrPheGluGluLysValSerGly-250 255-ValLeuGluArgArgProGluAsnLeuLysThrLeuAspGlyArgLysLeuIleAlaAlaGluLysAlaAsp SerAsn-280 312-AlaIleProGluAlaGlu-317 335-ArgAlaAlaAspArgGlyAspAspValTyrAla-345 347-AspProSerArgGln-351 361-ArgSerHisGlnAsnIleArgGly-368 370-AlaAlaAlaAspGlyArgArgLysGlyVal-379 385-ValPheValArgGlnAsnGluGlySerArg-394 410-ValAsnGlyLysGlyGlyAla-416 435-LeuArgAspLysGlnThr-440 452-ArgPheLysHisArgIleAsnAspGluAsnArgAlaGluArgTyrLysThr-468 487-ValValGlyLysGlyAsnAsn-493 513-PheThrAspSerGluGlyThr-519 533-AlaGlyIleArgAlaLysThrArgPheAlaLeu-543 559-HisArgSerLysSerPheGlyValGluMetAspGlyGluLysGlnThrLeuAla-576 579-ThrAlaLeuGluGly-583 600-GlyTyrGlyLysArgThrAspGlyAspLysGluAlaAlaLeu-613 a990 AMPHI Regions - AMPHI 76-IleThrAspThrTyrGlyAspAsnLeuLysAspAlaValLysLysGlnLeuGlnAspLeuTyrLys-97 131-AspLeuIleAsnLysLeuVal-137 151-ThrSerLeuAsnAsnIlePhe-157 195-AspIleHisMetLeu-199 260-ProGluAsnLeuLysThrLeuAspGly-268 293-TyrGluLeuLeuLeuLysGlnCys-300 419-SerTyrLeuHisGlyTyrGlyGlyGlyValTyrAlaAlaTrp-432 442-AlaTyrLeuAspGlyTrpLeuGlnTyr-450 472-ThrAlaSerValGluGlyGlyTyrAsnAlaLeu-482 550-GlnProPheAlaAlaPheAsnValLeuHisArg-560 Antigenic Index - Jameson-Wolf 6-LeuGlySerAsnThrArgSerThr ysIleGlyAspAspAlaAspPheSerPheSerAspLysProLysProGl yThr-31 35-PheΞerSerGlyLysThrAspGlnAsnSerSerGluTyrGlyTyrAspGluIleAsnIleGlnGlyLysAsnT yrAsnSerGlyIle-63 75-TyrIleThrAspThrTyrGlyAspAsnLeuLysAspAlaValLysLysGlnLeuGlnAspLeuTyrLysThrA rgProGluAlaTrpGluGluAsnLysLysArgThrGluGluAlaTyr-114 123-SerIleLeuLysGlnLysAsnProAspLeuIle-133 145-HisSerAsnThrSerGlnThrSer-152 157-PheAsnLysLysLeuHisValLysIleGluAsnLysSerHisVal-171 179-Thr ysMetThrLeuLysAspSerLeuTrpGluProArgArgHisSerAspIleHisMet-198 200-GluThrSerAspAεnAlaArgIleArgLeuAsnThrLysAspGluLysLeuThrVal-218 222-TyrGlnGlyGlyAla-226 233-AspValArgGluSerAspLysProAlaLeuThrPheGluGluLysValSerGlyGlnSerGlyValValLeu GluArgArgProGluAsnLeuLysThrLeuAspGlyArgLysLeuIleAlaAlaGluLysAlaAspSerAεnSerP heAlaPheLysGlnAsnTyrArgGlnGlyLeu-292 298-LysGlnCysGluGlyGlyPhe-304 312-AlaIleProGluAlaGlu-317 335-ArgAlaAlaAspArgGlyAspAspValTyrAlaAlaAspProSerArgGlnLysLeu-353 358-IleGlyGlyArgSerHisGlnAsnIleArgGlyGlyAlaAlaAlaAspGlyArgArgLysGlyVal-379 385-ValPheValArgGlnAsnGluGlySerArgLeuAla-396 400-MetGlyGlyArgAlaGlyGln-406 408-AlaSerValAsnGlyLysGlyGlyAla-416 435-LeuArgAspLysGlnThrGlyAlaTyr-443 452-ArgPheLysHisArgIleAsnAspGluAsnArgAlaGluArgTyrLysThrLysGlyTrpThr-472 475-ValGluGlyGlyTyr-479 487-ValValGlyLysGlyAsnAεnValArg-495 510-AsnGlyGlyPheThrAspSerGluGlyThrAla-520 525-GlySerGlyGlnTrpGlnSerArgAlaGlyIleArgAlaLysThrArgPheAlaLeuArgAsnGlyValAsn -548 559-HisArgSerLysSerPheGlyValGluMetAspGlyGluLysGlnThrLeuAla-576 579-ThrAlaLeuGluGlyArgPheGlyIle-587 589-AlaGlyTrpLysGlyHisMet-595 600-GlyTyrGlyLysArgThrAspGlyAspLysGluAlaAlaLeu-613 Hydrophilic Regions - Hopp-Woods 8-SerAsnThrArgSerThrLysIleGlyAspAspAlaAspPheSerPheSerAεpLysProLysProGlyThr-3 1 38-GlyLysThrAspGlnAsnSerSer-45 79-ThrTyrGlyAspAsnLeuLysAspAlaValLysLysGlnLeuGlnAsp-94 96-TyrLysThrArgProGluAlaTrpGluGluAsnLysLyεArgThrGluGluAlaTyr-114 123-SerIleLeuLyεGlnLyεAsnProAspLeuIle-133 161-LeuHisValLysIleGluAsnLysSerHisVal-171 179-ThrLysMetThrLeuLys-184 186-SerLeuTrpGluProArgArgHisSerAsp-195 200-GluThrSerAspAsnAlaArgIleArgLeuAsnThrLysAspGluLysLeuThrVal-218 233-AspValArgGluSerAspLysProAlaLeuThrPheGluGluLysValSerGly-250 255-ValLeuGluArgArgProGluAsnLeuLysThrLeuAspGlyArgLysLeuIleAlaAlaGluLysAlaAsp SerAsn-280 312-AlaIleProGluAlaGlu-317 335-ArgAlaAlaAspArgGlyAspAspValTyrAla-345 347-AspProSerArgGln-351 361-ArgSerHisGlnAsnIleArgGly-368 370-AlaAlaAlaAspGlyArgArgLysGlyVal-379 385-ValPheValArgGlnAsnGluGlySerArg-394 410-ValAsnGlyLysGlyGlyAla-416 435-LeuArgAspLysGlnThr-440 452-ArgPheLysHisArgIleAsnAspGluAsnArgAlaGluArgTyrLysThr-468 487-ValValGlyLysGlyAsnAsn-493 513-PheThrAspSerGluGlyThr-519 533-AlaGlyIleArgAlaLysThrArgPheAlaLeu-543 559-HisArgSerLysSerPheGlyValGluMetAspGlyGluLysGlnThrLeuAla-576 579-ThrAlaLeuGluGly-583 600-GlyTyrGlyLysArgThrAspGlyAspLysGluAlaAlaLeu-613 a992 AMPHI Regions - AMPHI 6-ArgHisLeuLysAsnMetGlnIleLysLysIleMetLysTrp-19 24-LeuSerLeuLeuGlyAlaLeuGlyTyr-32 45-AlaValLeuAspValLeuGlyAlaAla-53 72-HisArgTyrThrGlyThrValSerLysValTyr-82 158-GlnValGlnAεpGly-162 179-AspPheAlaAspTyr-183 Antigenic Index - Jameson-Wolf l-MetPheArgArgHisArgHisLeuLyε-9 34-GlyTyrGlySerGluAlaValArg-41 52-AlaAlaGlyAspAlaGlySerAspAlaProAlaArgArgArgAlaSerAlaLysSerGlyHisArgTyrThr- 75 79-SerLysValTyrAspGlyAspThr-86 90-IleAspGlyAspGlyAlaLysHisLysIle-99 105-AspAlaProGluMetLysGlnAlaTyrGlyThrArgSerArgAspAsnLeuArgAlaAlaAlaGluGlyArg LysValSer-131 134-ValPheAspThrAspArgTyrGlnArgGluValAla-145 148-SerValGlyLysThrAspLeuAsn-155 168-LysSerTyrAlaLysGluGlnGlnAspLysAlaAspPhe-180 187-GlnIleGlnAlaGluArgGluArgLysGlyLeuTrpLysAlaLysAsnProGlnAlaPro-206 208-AlaTyrArgArgAlaGlyArgSerGlyGlyGlyAsnLysAspTrpMetAsp-224 Hydrophilic Regions - Hopp-Woods l-MetPheArgArgHisArgHisLeuLys-9 54-GlyAspAlaGlySerAspAlaProAlaArgArgArgAlaSerAlaLysSerGlyHisArg-73 90-IleAspGlyAspGlyAlaLysHisLysIle-99 105-AspAlaProGluMetLysGln-lll 113-TyrGlyThrArgSerArgAspAsnLeuArgAlaAlaAlaGluGlyArgLysValSer-131 134-ValPheAspThrAspArgTyrGlnArgGluValAla-145 148-SerValGlyLyεThrAspLeu-154 169-SerTyrAlaLysGluGlnGlnAspLysAlaAspPhe-180 187-GlnIleGlnAlaGluArgGluArgLysGlyLeuTrpLysAlaLysAsnPro-203 211-ArgAlaGlyArgSerGlyGlyGlyAsnLysAspTrpMet-223 a993 AMPHI Regions - AMPHI 6-SerSerPheGlnGlyProLeuAspLeuLeuLeu-16 35-ThrGluGlnTyrLeuHisTyrIleAlaGlnIle-45 105-GlyLeuAspAlaLeuProArgAla-112 136-IleThrAspLeuThrGlnAlaTrpLeuSer-145 152-HisThrArgSerHisGluValIle-159 169-MetThrAlalleLeuArgArgLeuAsnLysHisGlyIleCysArgPheHisAspLeuPheAsnProGlu-19 1 199-ValAsnPheIleAlaLeuLeu-205 Antigenic Index - Jameson-Wolf 7-SerPheGlnGlyProLeu-12 20-ArgLysGlnAsnIleAsp-25 70-LeuLeuLeuProArgThrGluThrValGluAspGluGluAlaAspProArgAlaGluLeuValArg-91 108-AlaLeuProArgAlaGlyArgAspPhe-116 148-SerArgAlaLysHisThrArgSerHisGluValIleLysGluThrIleSer-164 174-ArgArgLeuAsnLysHisGlyIle-181 188-PheAsnProGluGlnGly-193 207-LeuAlaLysGluGlyLeu-212 228-LeuAsnHisGluGlyAlaHisSerAspGlyIleSerGlyThrArgGlyGlyArgAspValPhe-248 Hydrophilic Regions - Hopp-Woods 20-ArgLysGlnAsnIleAsp-25 70-LeuLeuLeuProArgThrGluThrValGluAεpGluGluAlaAεpProArgAlaGluLeuValArg-91 108-AlaLeuProArgAlaGlyArg-114 148-SerArgAlaLysHisThrArgSerHisGluValIleLysGluThrIleSer-164 174-ArgArgLeuAsnLys-178 207-LeuAlaLysGluGlyLeu-212 232-GlyAlaHisSerAspGlyIleSerGlyThrArgGlyGlyArgAspValPhe-248 a996 AMPHI Regions - AMPHI 21-LysSerAlaArgThrHisAlaLysIlePro-30 50-ProGlyGluSerTyrProAlaGlnLeuGlnLysLeuThrGlyTrpAsn-65 75-ThrSerAlaGlnAlaLeuSerArgLeuProAla-85 104-LeuArgLysValProLysGlu-llO 115-AsnIleAlaLysIleIleGluThrValGlnLys-125 140-LeuGlyAlaLeuPheGlyHisLeuSerAsp-149 167-GlyAlaTrpAlaGlu-171 186-AsnGlyLysGlyTyrArgLysPheAlaGluAspLeuAsnGlnPheLeuArgLysGlnGlyPhe-206 Antigenic Index - Jameson-Wolf 1-MetAsnArgArgThrPhe-6 18-CysGlyArgLysSerAlaArgThrHisAlaLysIleProGluGlySerThr-34 46-TyrGlyAlaAsnProGlyGluSerTyrPro-55 69-GlyGlyValSerGlyAspThrSerAla-77 87-LeuAlaArgLysProLys-92 99-GlyGlyAsnAspPheLeuArgLysValProLysGluGlnThrArgAlaAsnIle-116 121-GluThrValGlnLysGluAsnIlePro-129 148-SerAspHisProLeuTyrGluAspLeuSerGluGluTyrGly-161 173-LeuGlyAspAsnAsnLeuLysSerAspGlnIleHisAlaAsnGlyLysGlyTyrArgLysPheAlaGluAsp LeuAsnGlnPheLeuArgLysGlnGlyPheArg-207 Hydrophilic Regions - Hopp-Woods 18-CysGlyArgLysSerAlaArgThrHisAlaLysIleProGlu-31 49-AsnProGlyGluSerTyr-54 71-ValSerGlyAspThrSerAla-77 87-LeuAlaArgLysProLys-92 102-AspPheLeuArgLysValProLyεGluGlnThrArgAlaAsnIle-116 121-GluThrValGlnLyεGluAsnIle-128 154-GluAspLeuSerGluGluTyrGly-161 176-AsnAsnLeuLysSerAspGlnIleHisAlaAsn-186 188-LysGlyTyrArgLysPheAlaGluAspLeuAsnGlnPheLeuArg-202 a997 AMPHI Regions - AMPHI 18-TrpAlaGlyLeuSerAlaAlaVal-25 70-TyrArgGlyValLeuArgLeuMetLysThrIleGlySerAεp-83 107-ProLeuProAlaProLeuHisIle-114 123-ArgValProSerAlaPheLysAlaLysLeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGly -146 164-AlaAlaValMetGlnPheTrpGlnProLeuValTrpGly-176 189-ValLeuCysAsnValLeuSerAsp-196 222-AlaLeuAlaGluLeuGlnArg-228 241-ArgLeuAsnThrLeuPro-246 275-GluGlyThrProGluHisValGlnThrAla-284 300-TyrAlaGluProValArgLeuProAlaProLeuThrGlyLeuAlaAspGly-316 354-AspLysValHisAlaAspLeuLysArgIleLeuProHisLeu-367 369-GluProGluAlaVal-373 Antigenic Index - Jameson-Wolf 3-AsnThrProHisProArgProLysIle-ll 37-GluAlaGlyArgGlnAlaGlyGlyArgAlaArgAla-48 50-AlaGlyAsnThrAspGlyPheGly-57 78-LysThrIleGlySerAspProHisAla-86 122-ArgArgValProSerAlaPheLys-129 132-LeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGlyGlnProAspThrThr-151 156-LeuLysGlnArgAsnValProArg-163 180-ThrProLeuGluThrAlaSer-186 197-GlyValLeuThrLyεLysSerGlySerAspTyrLeuLeuProLysGlnAspLeu-214 225-GluLeuGlnArgLeuGlyAlaAspIleArgLeuGluThrArgIleCysArg-241 243-AsnThrLeuProAspGlyLysVal-250 273-LeuProGluGlyThrProGluHisVal-281 312-GlyLeuAlaAspGlyThr-317 323-CysArgGlyArgLeuGlyLeuProGluAsnGluVal-334 340-ValSerAspArgValGlyAla-346 356-ValHisAlaAspLeuLysArgIleLeu-364 367-LeuGlyGluProGluAlaValArgValIleThrGluLysArgAlaThrThrAlaAlaAspAlaProProPro AspLeu-392 402-ProAlaGlyAspTyrLeuHisProAspTyrProAla-413 Hydrophilic Regions - Hopp-Woods 5-ProHisProArgProLysIle-ll 37-GluAlaGlyArgGlnAlaGlyGlyArgAlaArgAla-48 80-IleGlySerAspPro-84 122-ArgArgValProSer-126 132-LeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGlyGlnProAspThrThr-151 198-ValLeuThrLysLysSerGlySer-205 208-LeuLeuProLysGlnAspLeu-214 225-GluLeuGlnArgLeuGlyAlaAspIleArgLeuGluThrArglleCysArg-241 246-ProAspGlyLysVal-250 276-GlyThrProGluHisVal-281 325-GlyArgLeuGlyLeuProGluAsnGluVal-334 340-ValSerAspArgValGly-345 356-ValHisAlaAspLeuLysArgIleLeu-364 368-GlyGluProGluAlaValArgValIleThrGluLysArgAlaThrThrAlaAlaAspAlaProProPro-39 0 gOOl AMPHI Regions - AMPHI 7-AlaAlaArgArgValSer-12 17-SerGlyArgAlaCys-21 67-AlaArgPhePheGlySerValCysAsnSerAla-77 Antigenic Index - Jameson-Wolf 3-ProGlnGlyLysAlaAlaArgArgValSerAlaAsnGluValSerGlyArgAlaCysAla-22 31-ThrLeuProLyεArgAspThrLeuAsnGlySerGlyThr-43 53-ProArgSerLeuArgSerLysSerThr-61 68-ArgPhePheGlySer-72 74-CysAsnSerAlaAlaArgArgSerSerCysProSerProLysIleGly-89 100-ValProSerGluAlaMetLeuArgLysSerSerGlyGluLysHisSerVal-116 119-AspCyεProAlaSerSerGlyArgTrpAspAsnThrAla-131 Hydrophilic Regions - Hopp-Woods 5-GlyLysAlaAlaArgArgValSerAlaAsnGluValSerGly-18 32-LeuProLysArgAspThrLeuAsn-39 54-ArgSerLeuArgSerLysSer-60 77-AlaAlaArgArgSerSerCysProSerProLys-87 104-AlaMetLeuArgLysSerSerGlyGluLysHisSerVal-116 125-GlyArgTrpAspAsn-129 g003 AMPHI Regions - AMPHI 72-AsnGlnValValLeu-76 82-ValValGluValPheGlnArg-88 150-ValGlnAlaGluPheValGlyIleValGlyHisPheAspGlyLeuGlyMet-166 173-HisPhePheValArgValPheArg-180 Antigenic Index - Jameson-Wolf 104-PheGluGlyGlyGlyAspAspGlyPhe-112 137-GlyArgIleAsnAspAlaGluIleIle-145 204-ProLysAlaAlaAlaGlyGluValAsnGly-213 215-ArgValHisAspCys-219 Hydrophilic Regions - Hopp-Woods 106-GlyGlyGlyAspAspGlyPhe-112 137-GlyArgIleAsnAspAlaGluIleIle-145 205-LysAlaAlaAlaGlyGluValAsnGly-213 215-ArgValHisAspCys-219 g005 AMPHI Regions - AMPHI 16-IleGlnSerMetTrpLysGlu-22 32-LeuGluLeuLeuThrValPheGlyAlaIleAla-42 62-LeuThrAspPheSerGluAsnTyr-69 107-ArgLeuLysGluGlyGlyGluLysSerAlaGlu-117 177-GlnLeuArgArgLeuArg-182 213-AlaProPheAlaValIleGlySerValGlyValValAlaGluValProAsnIleHisArgLeuLeuLysLys -236 249-PheLysArgThrVa1-253 274-ThrHisGlnLeuPheLysGln-280 308-LeuAsnLeuIleAspGluIleSerThr-316 320-LeuLeuLeuLysAlaPhe-325 Antigenic Index - Jameson-Wolf l-MetGlyMetAspAsn-5 10-MetProGluGlnGluGluIleGlnSerMetTrp-20 50-GlnSerLysLysGlnSerGluSerGlySer-59 64-AspPheSerGluAsnTyrLysLysGlnArgGlnSerPhe-76 82-SerGluGluGluThrLysHisGlnGluLysLysGluLysLysLysGluLysAlaGluAlaLysAlaGluLysL ysArgLeuLysGluGlyGlyGluLysSerAlaGluThrGlnLysSerArg-122 138-GluSerLeuArgHisGluIle-144 151-AlaLysProGluAspGluValLeuLeu-159 161-LeuGluSerProGlyGlyVal-167 177-GlnLeuArgArgLeuArgGluArgAsnIle-186 191-AlaValAspLysValAlaAla-197 232-ArgLeuLeuLysLysHisAspIleAspVal-241 247-GlyGluPheLysArgThr-252 258-GluAsnThrGluLysGlyLysGlnLysPheArgGlnGluLeuGluGluThrHisGln-276 281-PheValSerGluAsnArgProGlyLeuAspIleGluLysIleAlaThr-296 312-AspGluIleSerThrSerAspAspLeuLeu-321 325-PheGluAsnLysGlnValIle-331 334-LysTyrGlnGluLysArgSerLeuIle-342 351-AlaSerValGluLysLeuPhe-357 361-ValAsnArgArgAlaAspVal-367 Hydrophilic Regions - Hopp-Woods 10-MetProGluGlnGluGluIleGlnSerMetTrp-20 50-GlnSerLysLysGlnSerGluSerGly-58 64-AspPheSerGluAsnTyrLysLysGlnArgGlnSerPhe-76 82-SerGluGluGluThrLysHisGlnGluLysLysGluLysLysLysGluLysAlaGluAlaLysAlaGluLysL ysArgLeuLysGluGlyGlyGluLysSerAlaGluThrGlnLysSerArg-122 138-GluSerLeuArgHisGluIle-144 151-AlaLysProGluAspGluValLeuLeu-159 161-LeuGluSerProGly-165 177-GlnLeuArgArgLeuArgGluArgAsnIle-186 191-AlaValAspLysValAlaAla-197 232-ArgLeuLeuLysLysHisAspIleAspVal-241 247-GlyGluPheLysArg-251 258-GluAsnThrGluLysGlyLysGlnLysPheArgGlnGluLeuGluGluThrHisGln-276 281-PheValSerGluAsnArgProGlyLeuAspIleGluLysIleAlaThr-296 312-AspGluIleSerThrSerAspAspLeuLeu-321 325-PheGluAsnLysGlnValIle-331 334-LysTyrGlnGluLysArgSerLeuIle-342 351-AlaSerValGluLysLeuPhe-357 361-ValAsnArgArgAlaAspVal-367 g006-l AMPHI Regions - AMPHI 6-LysHisIleAlaLysThrHisArgLysArg-15 19-ThrPheSerProValGlyLeuGluAsnLeuLeu-29 48-ArgValTrpGlnAlaLeuLeuTyrAlaLeuValValPhe-60 69-ArgArgIleAlaAspThrArgThrPheThrArgIleTyrThrGlu-83 lll-GluPheValSerPhePheGlu-117 125-ThrSerValValSerIlePheGlyAlaCysIleMetLeuLeu-138 195-HisTyrGlyLeuValSerArgLeu-202 236-GlyTyrGlySerAlaGlyHisIleTyrSer-245 257-LeuAspAspValProArgLeuValGluGlnTyrSerAsnLeuLysAspIle-273 Antigenic Index - Jameson-Wolf 6-LysHisIleAlaLysThrHisArgLysArgLeu-16 67-AlaAlaArgArgl1eAlaAspThrArgThrPheThr-78 90-LeuGluGlnArgGlnArgGlnValProHisSer-100 173-LeuAsnAsnSerLeuGluArgAspAsnHisPheIleArgLysGlyAspGluArgGlnLeuTyr-193 206-IleSerAsnArgGluAlaPhe-212 256-SerLeuAspAspValProArgLeuValGluGlnTyrSerAsnLeuLysAspIleGlyGlnArgIleGluTrp SerGluArgAsnIleLysAlaGlyThr-288 Hydrophilic Regions - Hopp-Woods 6-LysHisIleAlaLysThrHisArgLysArgLeu-16 67-AlaAlaArgArgIleAlaAspThrArgThrPhe-77 90-LeuGluGlnArgGlnArgGlnValPro-98 175-AsnSerLeuGluArgAspAsnHisPheIleArgLysGlyAspGluArgGlnLeu-192 206-IleSerAsnArgGluAla-211 256-SerLeuAspAspValProArgLeuValGlu-265 268-SerAsnLeuLysAspIleGlyGln-275 277-IleGluTrpSerGluArgAsnIleLyεAlaGlyThr-288 g007-l AMPHI Regions - AMPHI 71-HisSerMetValLysGlyIleAsn-78 105-ValAlaThrTyrIleMetAsnAlaPheAspAsnGlyGlyGly-118 Antigenic Index - Jameson-Wolf 1-MetAsnThrThrArgLeuProThr-8 20-SerAlaAlaAspAsnSerIleMetThrLysGlyGlnLysValTyrGluSerAsnCys-38 41-CysHisGlyLysLysGlyGluGlyArgGlyThrAlaPhePro-54 56-LeuPheArgSerAspTyrIleMetAsnLysPro-66 81-IleLysValAsnGlyLysThrTyrAεnGly-90 98-SerAspAlaAspIle-102 112-AlaPheAspAsnGlyGlyGlySerValThrGluLyεAspValLysGlnAlaLysGlyLysLysAsn-133 Hydrophilic Regions - Hopp-Woods 26-IleMetThrLysGlyGlnLysValTyrGlu-35 42-HisGlyLysLysGlyGluGlyArgGly-50 98-SerAspAlaAspIle-102 119-SerValThrGluLysAspValLysGlnAlaLysGlyLyεLyAsn-133 g008 AMPHI Regions - AMPHI 15-LeuAspAsnProAlaGlnGlnIleArgGlyAlaLeuAεpAlaLeuSer-30 54-GlnProAεpPheIleAεnAlaVal-61 63-ThrValSerThrThr-67 69-AspGlyIleAlaLeuLeuAlaGluLeuAsnArg-79 90-PheArgAsnAlaPro-94 129-ArgProLeuAlaGluIleLeuProAsp-137 140-LeuGlyLysTyrGlyLysValValGluLeuSerLysArgLeuGly-154 Antigenic Index - Jameson-Wolf l-MetAsnAsnArgHis-5 12-GlySerAsnLeuAspAsnProAlaGlnGlnIleArgGlyAlaLeu-26 29-LeuSerSerHisProAspIleArgLeuGluGln-39 49-ValGlyTyrAspAsnGlnPrAspPhe-57 76-GluLeuAsnArgIleGluAlaAspPheGlyArgGluArgSerPheArgAsnAlaProArgThrLeuAspLeuA spIlelleAspPheAspGlylleSerSer spAspProArgLeuThrLeuProHisProArgAlaHisGluArgSe rPheVal-127 139-IleLeuGlyLysTyrGlyLyεValValGluLeuSerLysArgLeuGlyAsnGlnGlyIle-158 160-LeuLeuProAspArg-164 Hydrophilic Regions - Hopp-Woods 14-AsnLeuAspAsnProAlaGlnGlnIle-22 33-ProAspIleArgLeuGluGln-39 76-GluLeuAsnArgIleGluAlaAspPheGlyArgGluArgSerPheArgAsnAlaProArgThrLeuAsp-98 105-AspGlyIleSerSerAspAspProArgLeu-114 120-ArgAlaHisGluArgSerPheVal-127 147-ValGluLeuSerLysArgLeuGly-154 160-LeuLeuProAspArg-164 g009 Antigenic Index - Jameson-Wolf 6-ValAlaPheGluArgHisHisHisLysSerLysAlaGluGlnAsnThrHisArgArgAlaAspAlaGluIleAl aGlu-31 37-AsnGlnHisThrGlnAlaArgAsnGlnSerVal-47 57-PheSerAspLysVal-61 77-AlaAspGlyGlyLysThrTrpGlnLysPro-86 Hydrophilic Regions - Hopp-Woods 6-ValAlaPheGluArgHisHisHisLysSerLysAlaGluGlnAsnThrHisArgArgAlaAspAlaGluIleAl aGlu-31 40-ThrGlnAlaArgAsnGlnSer-46 78-AspGlyGlyLysThrTrpGln-84 gOlO-1 AMPHI Regions - AMPHI 54-SerAlaSerLeuGly-58 70-TyrAspThrValLysGly-75 115-TyrGlnArgProPheGlyGlyHiε-122 125-GluHisGlyLysArgAlaVal-131 146-LeuHisThrLeuTyrGln-151 210-AlaSerSerThrAsn-214 216-TyrMetAsnThrGlyAspGly-222 275-ArgTyrAlaProThrValLys-281 322-IleMetGluLysLeuProGlyIleArg-330 338-GlyIleAspProIleLysAspProIlePro-347 357-GlyGlyIleProThrAsnTyrHis-364 Antigenic Index - Jameson-Wolf 15-GlyGlyGlyAlaGly-19 26-LeuSerLysSerGlyLeu-31 40-PheProThrArgSerHis-45 59-AsnValGlnGluAspArgTrpAsp-66 71-AspThrValLysGlySerAspTrpLeuGlyAspGlnAspAlaIle-85 104-MetProPheAspArgValGluSerGlyLysIleTyrGlnArgProPheGly-120 123-ThrAlaGluHisGlyLysArgAlaValGluArgAlaCyεAlaValAlaAspArgThrGly-142 152-GlnAsnValArgAlaAsnThr-158 168-AspLeuIleArgAspGluAsnGlyAspVal-177 183-MetGluMetGluThrGlyGlu-189 202-ThrGlyGlyGlyGlyArgIle-208 218-AsnThrGlyAspGly-222 231-IleProLeuGluAspMetGlu-237 255-GluGlyValArgGlyGluGlyGlyIle-263 266-AsnAlaAspGlyGluArgPheMetGlu-274 276-TyrAlaProThrValLysAspLeuAlaSerArgAspValValSer-290 297-IleTyrGluGlyArgGlyCysGlyLysAsnLysAspHisVal-310 315-AspHisIleGlyAlaGluLysIleMetGluLysLeuProGlyIleArgGluIleSer-333 338-GlyIleAspProIleLysAspProIle-346 368-ValValProGlnGlyAspGluTyrGluValProVal-379 395-GlyAlaAsnArgLeuGlyThrAsnSerLeu-404 411-ArgProThrProArg-415 Hydrophilic Regions - Hopp-Woods 27-SerLysSerGlyLeu-31 59-AsnValGlnGluAspArgTrpAsp-66 71-AspThrValLysGly-75 77-AspTrpLeuGlyAspGlnAspAlalle-85 105-ProPheAspArgValGluSerGlyLysIleTyr-115 123-ThrAlaGluHisGlyLysArgAlaValGluArgAlaCysAlaValAlaAspArgThrGly-142 168-AspLeuIleArgAspGluAsnGlyAsp-176 183-MetGluMetGluThrGlyGlu-189 231-IleProLeuGluAspMetGlu-237 255-GluGlyValArgGlyGluGly-261 267-AlaAspGlyGluArgPheMetGlu-274 276-TyrAlaProThrValLysAspLeuAlaSerArgAspValValSer-290 297-IleTyrGluGlyArgGlyCysGlyLysAsnLysAspHisVal-310 315-AspHisIleGlyAlaGluLysIleMetGluLysLeuProGlyIleArgGluIleSer-333 340-AspProIleLysAspProIle-346 371-GlnGlyAspGluTyrGluValProVal-379 gOll AMPHI Regions - AMPHI 58-IleArgLeuIleAsnAlaAla-64 83-AlaIleLeuThrLys-87 116-AspValLeuHisArgTyrLeuProGlnMetLeuSerAlaGly-129 142-ThrGlyAlaAlaGlyMetAlaAεpMetGlyLysValMet-154 Antigenic Index - Jameson-Wolf l-MetLysThrHisArgLysThrCysSer-9 17-ThrAlaSerLysProAlaValSerIleArgHisProSerGluAspIleMetSerLeuLysThrArgLeuThrG luAspMetLysThrAlaMetArgAlaLysAspGlnVal-53 66-LysGlnPheGluValAspGluArgThrGluAlaAspAspAlaLysIle-81 88-MetValLysGlnArgLysAεpGlyAlaLysIleTyrThrGluAlaGlyArgGlnAspLeuAlaAspLysGluA snAlaGluIle-115 127-SerAlaGlyGluIleArgThrAlaVal-135 159-ThrArgLeuAlaGlyLysAlaAspMetGlyGluValAsnLysIleLeu-174 Hydrophilic Regions - Hopp-Woods 1-MetLysThrHisArgLysThrCys-8 27-HisProSerGluAspIleMetSerLeuLysThrArgLeuThrGluAspMetLysThrAlaMetArgAlaLysA spGlnVal-53 66-LysGlnPheGluValAspGluArgThrGluAlaAspAspAlaLyεIle-81 88-Me ValLysGlnArgLysAspGlyAlaLysIleTyrThrGluAlaGlyArgGlnAspLeuAlaAspLysGluA snAlaGluIle-115 129-GlyGluIleArgThrAlaVal-135 159-ThrArgLeuAlaGlyLysAlaAspMetGlyGluValAsnLysIleLeu-174 g012-l AMPHI Regions - AMPHI 18-AspLysLeuLeuGluGlnLeuMetArgPheLeuGlnPheLeuProGluPheLeuPheAlaLeuPheArgIle- 41 48-ArgAlaLeuLysPheAlaArgArg-55 89-AsnAsnPheIleArgHisThr-95 100-AlaAlaAlaCyεArgAsp-105 133-HisAlaAlaArgThrPhe-138 160-GlnGlyPheTyrGlyVal-165 179-GlyPheLeuArgPheGlyArgPheLeuProAlaLeuLeuGlnThrLeu-194 Antigenic Index - Jameson-Wolf 42-PheThrHisLysSerAsnArgAlaLeuLysPheAlaArgArgHisHis-57 72-ArgHisPheArgHisHisThrHisArgThrAspAspArgLysArgSerGlyAsnAsnPheIleArgHisThrA rg-96 102-AlaCysArgAspLeuIleAspGlyAspGlyGlnArgAsn-114 119-GlnThrProLysLeuArgSerArgGln-127 137-ThrPheGlnSerGluGlnAsnLeu-144 147-ArgLeuGlyAsnGlnLysHisArgArgAsnLeuMetThrGln-160 173-IleGlnHisLysLysAlaGly-179 Hydrophilic Regions - Hopp-Woods 45-LysSerAsnArgAlaLeuLysPheAlaArgArgHisHis-57 77-HisThrHisArgThrAspAspArgLysArgSerGly-88 102-AlaCysArgAspLeuIleAspGlyAspGlyGlnArg-113 121-ProLysLeuArgSerArgGln-127 149-GlyAsnGlnLysHisArgArgAsnLeu-157 173-IleGlnHisLysLysAlaGly-179 g015 AMPHI Regions - AMPHI 36-LeuValGlyPheTrpLysAlaLeuProHis-45 107-MetCysCysIleAlaCys-112 Antigenic Index - Jameson-Wolf 29-TrpLysAsnProGluLysProLeu-36 90-MetArgAlaArgProArgSerThrLys-98 Hydrophilic Regions - Hopp-Woods 31-AsnProGluLysProLeu-36 90-MetArgAlaArgProArgSerThrLys-98 g018-2 AMPHI Regions - AMPHI 6-IleGlnHisLeuArg-10 15-HisLeuMetArgProCysGlnGlnValSerGlnMetPheGly-28 152-ArgIleGlyAsnGlyTyr-157 Antigenic Index - Jameson-Wolf l-MetValGluArgHisIleGln-7 9-LeuArgAsnGlyHisLeu-14 27-PheGlyGlyArgAlaTyrAspPheArgAlaAspLysAlaAlaGly-41 67-TyrPheAlaAspAspLysPhe-73 78-LeuArgGlyAsnLeuArg-83 85-PheGlnThrAspLysAlaAspLeuArgThrGlyLysHisHisAlaAsnGly-101 108-AlaAspIleArgValAlaAla-114 136-ArgValAlaArgAsnLysAspMetArgAsnAlaGlyLeuHis-149 152-ArgIleGlyAsnGlyTyr-157 176-ArgThrAlaThrTyr-180 223-SerGluHisGlyPheArg-228 Hydrophilic Regions - Hopp-Woods l-MetValGluArgHisIleGln-7 30-ArgAlaTyrAspPheArgAlaAspLysAlaAla-40 67-TyrPheAlaAεpAspLysPhe-73 85-PheGlnThrAspLysAlaAspLeuArgThrGlyLysHisHisAla-99 108-AlaAεpIleArgValAlaAla-114 136-ArgValAlaArgAsnLysAspMetArgAsn-145 g019-2 AMPHI Regions - AMPHI 33-ProAlaAspAsnIleGlu-38 55-GlyLysThrLeuAlaAspTyrGlyGlyTyrProSerAlaLeuAspAlaValLysGln-73 83-LeuGluAsnThrGlyAsp-88 90-AlaMetAlaGluAsnValArgLysGluTrpLeuLysSer-102 142-AlaAlaGluLeuValXxxAsnThrGlyLysLeuProSerGlyCysThrLysLeuLeuGluGlnAla-163 173-AspAlaTrpArgGlyValArgGlyLeu-181 195-AlaAlaLeuGlySerProPheAspGlyGlyThrGlnGly-207 215-AsnValIleGlyLysGluAlaArgLysSer-224 229-AlaLeuLeuSerGluMetGlu-235 259-AsnValProAlaAlaLeuAspTyrTyrGly-268 292-ArgArgTrpAspGluLeuAlaSerValIleSerHisMetProGluLysLeuGlnLys-310 329-GlnGluAlaGluLysLeuTyrLyεGlnAla-338 451-ArgTyrIleSerPro-455 495-GlnGlyLeuMetGlnValMet-501 582-ArgAspTyrValLysLysValMet-589 Antigenic Index - Jameson-Wolf 22-SerSerThrAsnThr-26 28-ProAlaGlyLysThrProAlaAspAsnIleGluThrAlaAspLeuSerAlaSerValProThrArgProAlaG luProGluGlyLysThrLeuAlaAspTyrGlyGlyTyrProSerAla-67 69-AspAlaValLysGlnAsnAεnAspAlaAla-78 84-GluAsnThrGlyAspSerAlaMet-91 93-GluAsnValArgLysGluTrpLeu-100 103-LeuGlyAlaArgArgGln-108 115-GluTyrAlaLysLeuLysProGluGlyGlyAlaGlnGluValGluCysTyrAlaAspSerSerArgAsnAsp TyrThrArgAlaAlaGlu-144 147-XxxAsnThrGlyLysLeuProSerGlyCys-156 170-GlyGlyAsnAspAlaTrpArgGlyValArg-179 182-LeuAlaGlyArgProThrThrAspGlyArgAsn-192 199-SerProPheAspGlyGlyThrGlnGlySerArgGluTyr-211 217-IleGlyLysGluAlaArgLysSerProAsnAla-227 232-SerGluMetGluSerGlyLeuSerProGluGlnArgSer-244 254-GlnSerGlnSerLeu-258 266-TyrTyrGlyLysValAlaAspArgArgGlnLeuThrAspAspGlnIle-281 287-AlaAlaLeuArgAlaArgArgTrpAspGlu-296 304-MetProGluLysLeuGlnLysSerProThr-313 320-ArgSerArgAlaAlaThrGlyAsnThrGlnGluAlaGluLysLeuTyrLys-336 339-AlaAlaThrGlyArgAsn-344 350-AlaGlyGluGluLeuGlyArgLysIleAspThrArgAsnAsnValProAspAlaGlyLysAεnSerVal-37 2 374-ArgMetAlaGluAspGlyAlaIleLys-382 389-ArgAsnSerArgThrAlaGlyAspAlaLysMetArgArgGlnAlaGlnAla-405 409-PheAlaThrArgGlyPheAspGluAspLysLeuLeu-420 438-SerAlaGluArgThrAspArgLysLeuAsnTyr-448 454-SerProPheLysAspThrValIle-461 464-AlaGlnAsnValAsnValAspProAla-472 478-IleArgGlnGluSerArgPhe-484 488-AlaGlnSerArgValGlyAla-494 504-ThrAlaArgGluIleAlaGly-510 520-TyrThrAlaAspGlyAsnIleArgMetGly-529 535-AspThrLysArgArgLeuGlnAsnAsnGluIle-545 550-GlyTyrAsnAlaGlyProGlyArgAlaArgArgTrpGlnAlaAspThrProLeuGlu-568 579-SerGluThrArgAspTyrValLys-586 605-ProLeuLysGlnArgMetGlyThrValProAlaArg-616 Hydrophilic Regions - Hopp-Woods 30-GlyLysThrProAlaAspAsnIleGluThrAlaAspLeu-42 46-ValProThrArgProAlaGluProGluGlyLysThrLeuAla-59 69-AspAlaValLysGlnAsnAsnAspAlaAla-78 85-AsnThrGlyAspSerAlaMet-91 93-GluAsnValArgLysGluTrpLeu-100 103-LeuGlyAlaArgArgGln-108 115-GluTyrAlaLysLeuLysProGluGlyGlyAlaGlnGluValGluCysTyrAlaAspSerSerArgAsnAsp TyrThrArgAlaAlaGlu-144 150-GlyLysLeuProSerGlyCys-156 173-AspAlaTrpArgGly-177 186-ProThrThrAspGlyArgAsn-192 201-PheAspGlyGlyThrGlnGlySerArgGlu-210 217-IleGlyLysGluAlaArgLysSerProAsn-226 232-SerGluMetGluSerGlyLeuSerProGluGlnArgSer-244 270-ValAlaAspArgArgGlnLeuThrAspAspGlnIle-281 287-AlaAlaLeuArgAlaArgArgTrpAspGlu-296 304-MetProGluLysLeuGlnLys-310 320-ArgSerArgAlaAlaThr-325 327-AsnThrGlnGluAlaGluLysLeuTyrLys-336 350-AlaGlyGluGluLeuGlyArgLysIleAεpThrArgAsnAsnValProAspAlaGlyLys-369 374-ArgMetAlaGluAspGlyAlaIleLys-382 389-ArgAsnSerArgThrAlaGlyAspAlaLysMetArgArgGlnAlaGlnAla-405 411-ThrArgGlyPheAspGluAspLysLeuLeu-420 438-SerAlaGluArgThrAspArgLysLeu-446 478-IleArgGlnGluSerArgPhe-484 504-ThrAlaArgGluIleAlaGly-510 535-AspThrLysArgArgLeuGlnAsn-542 554-GlyProGlyArgAlaArgArgTrpGlnAla-563 579-SerGluThrArgAspTyrValLys-586 606-LeuLysGlnArgMetGly-611 g023 AMPHI Regions - AMPHI 43-GluTyrProAlaTrpGlnAlaPhePheSerGlnAlaTrpValLysValPheThrGlnValSerPheIleAlaV alPheLeuHisAlaTrpValGly-74 77-AspLeuTrpMetAspTyrlleLys-84 Antigenic Index - Jameεon-Wolf l-MetValGluArgLysLeuThr-7 40-LeuProLysGluTyrProAlaTrp-47 Hydrophilic Regions - Hopp-Woods l-MetValGluArgLysLeuThr-7 g025 AMPHI Regions - AMPHI 9-AlaAlaCysThrAlaValAlaAlaLeuLeuGlyGlyCysAla-22 35-GlyMetGlnThrValSerSer-41 46-AsnProTyrGlyAlaThrProTyr-53 126-AspPheArgAlaTrpAsnGlyMetThrAsp-135 140-IleGlyGlnIleValLysVal-146 173-ValLysProAlaAla-177 181-ValGlnSerAlaProGlnPro-187 212-SerGlyThrArgSer-216 229-LysValValAlaAspPhe-234 265-GlyLeuArgGlyTyrGlyAsn-271 Antigenic Index - Jameson-Wolf 22-AlaThrGlnGlnPro-26 108-ValArgGlyAspThr-112 115-AsnIleSerLysArgTyrHisIleSerGlnAspAspPheArgAla-129 131-AsnGlyMetThrAspAsnThrLeu-138 144-ValLysValLysProAlaGly-150 152-AlaAlaProLysThrAlaAlaValGluSerArgProAlaValPro-166 171-ThrProValLysProAlaAlaGlnProProValGlnSerAlaProGlnPro-187 190-ProAlaAlaGluAsnLysAlaValPro-198 202-ProAlaProGlnSerProAlaAlaSerProSerGlyThrArgSerValGly-218 224-ArgProThrGlnGlyLysValValAlaAspPheGlyGlyGlyAsnLysGlyValAsp-242 255-AlaAspGlyLysVal-259 264-SerGlyLeuArgGlyTyrGly-270 285-TyrGlyHisAsnGln-289 292-LeuValGlyGluGlyGlnGlnValLysArgGlyGlnGln-304 309-GlyAsnThrAspAlaSerArgThrGlnLeu-318 320-PheGluValArgGlnAsnGlyLysProValAsnProAsnSer-333 Hydrophilic Regions - Hopp-Woods 108-ValArgGlyAspThr-112 120-TyrHisIleSerGlnAspAspPheArg-128 144-ValLysValLysPro-148 157-AlaAlaValGluSerArgProAla-164 171-ThrProValLysProAlaAla-177 190-ProAlaAlaGluAsnLysAlaValPro-198 212-SerGlyThrArgSer 235-GlyGlyGlyAsnLysGlyValAsp-242 255-AlaAspGlyLysVal-259 295-GluGlyGlnGlnValLysArgGlyGln-303 311-ThrAspAlaSerArgThr-316 322-ValArgGlnAsnGlyLysProValAsn-330 g032 AMPHI Regions - AMPHI 9-AlaValLeuArgArgProArgPheGlu-17 67-ProPheAlaGlyAsnValTyrProArgPheValGlnIle-79 114-ValHisGlyGlnIleGlnHisProValGlnProPheLeuArg-127 134-LeuGlyLeuLeuArgArgPheAspVal-142 174-GlnThrAlaLeuArg-178 204-LeuCysGlnGlnCysLysGlnPhePheGlnIleAla-215 Antigenic Index - Jameson-Wolf l-MetArgArgAsnVal-5 10-ValLeuArgArgProArgPhe-16 28-ArgAlaValProAlaGlyLysGlnGlyPhe-37 41-CysArgLeuThrGlnArg-46 58-GlyGlnArgAsnLeu-62 100-LeuGluGlnArgValValAlaHisArgGlnArgVal-lll 138-ArgArgPheAspValGlyGlyArgValGlyAla-148 151-ProAlaPheAspGlnProGlyAla-158 160-LeuProProArgArgGlnLeuAlaArgGlnArgProThrVal-173 176-AlaLeuArgGlnProProGlnArgArgArgLysIleAlaProArgGlnValLeu-193 202-ArgHisLeuCysGlnGlnCysLys-209 216-ProValCysArgAsnArgValLeuArg-224 236-ValLysIleArgArgLysProValGlnAsnHisAsnArgProThrGlnIleSerLysAsnGln-256 Hydrophilic Regions - Hopp-Woods l-MetArgArgAsnVal-5 10-ValLeuArgArgProArgPhe-16 41-CysArgLeuThrGln-45 100-LeuGluGlnArgValValAlaHisArgGlnArgVal-lll 138-ArgArgPheAspValGlyGly-144 161-ProProArgArgGlnLeuAlaArgGlnArgProThrVal-173 177-LeuArgGlnProProGlnArgArgArgLysIleAlaPro-189 218-CysArgAsnArgValLeu-223 236-ValLysIleArgArgLyεProValGlnAεnHisAsnArgProThrGlnIleSerLysAsnGln-256 g033-2 AMPHI Regions - AMPHI 6-GlnTyrGlyGlyLeuAlaGlyPheProLysArgCysGluSerGlu-20 64-GlyGlnAlaPheGluAlaLeuAsnCys-72 95-ValGlyAlaLeuProLysTyrLeuAlaSerAsnValValArgAspMetHisGlyLeuLeuSerThrVal-117 120-GlnThrGlyLysValLeuAspLysIleProGlyAlaMetGlu-133 142-IleLysThrLeuAlaGlu-147 157-SerLeu PheGluAsnPhe-162 168-GlyProValAspGlyHisAsnValGluAsnLeuValAspValLeuLysAspLeuArgSerArg-188 207-AlaGluAsnAspPro-211 213-LysTyrHisAlaValAlaAsnLeuProLysGluGlyGlyAla-226 242-TyrThrGlnValPheGlyLys-248 280-PheProAspArgTyrPheAspVal-287 307-LyεProValValAlaIleTyrSer-314 316-PheLeuGlnArgAlaTyrAεpGlnLeu-324 363-CysValProAsnMet-367 390-AlaProAlaAlaValArgTyrProArgGlyThr-400 406-ValSerAspGlyMetGluThrValGlu-414 419-IleIleArgArgGlu-423 453-MetArgPheValLysProIleAspGluGlu-462 469-ArgSerHisAspArgIle-474 489-AlaValLeuGluValLeu-494 510-AspThrValThrGluHisGlyAspProLysLysLeuLeu-522 Antigenic Index - Jameson-Wolf ll-AlaGlyPheProLysArgCysGluSerGluTyrAspAla-23 28-HisSerSerThrSerIle-33 41-AlaAlaAspLysLeuLeuGlyGlyAspArgArgSerVal-53 57-GlyAspGlyAlaMetThr-62 72-CysAlaGlyAspMetAspVal-78 85-AsnAspAsnGluMetSerIle-91 105-AsnValValArgAspMetHisGly-112 117-ValLysAlaGlnThrGlyLysValLeuAspLyεIleProGly-130 134-PheAlaGlnLyεValGluHisLysIleLysThrLeuAlaGluGluAlaGluHisAlaLysGln-154 166-TyrThrGlyProValAspGlyHisAsn-174 181-ValLeuLysAspLeuArgSerArgLysGlyProGln-192 197-IleThrLysLysGlyAsnGlyTyrLyεLeuAlaGluAsnAspProValLys-213 219-AsnLeuProLysGluGlyGlyAlaGlnMetProSerGluLysGluProLysProAlaAlaLysProThrTyr -242 253-ArgAlaAlaAlaAspSerArgLeu-260 266-AlaMetArgGluGlySerGlyLeuValGluPheGluGlnArgPheProAspArgTyrPhe-285 345-ValGlyAlaAspGlyProThrHis-352 370-AlaAlaProSerAspGluAsnGluCysArg-379 395-ArgTyrProArgGlyThrGlyThrGlyAlaProValSerAspGlyMetGluThrValGluIleGlyLysGly IleIleArgArgGluGlyGluLysThrAla-428 457-LysProIleAspGluGluLeuIle-464 467-LeuAlaArgSerHisAspArgIleValThrLeuGluGluAsnAlaGluGlnGlyGlyAlaGlyGly-488 511-ThrValThrGluHisGlyAspProLysLysLeuLeuAspAspLeuGlyLeu-527 530-GluAlaValGluArgArgValArgGluTrpLeuProAspArgAspAlaAlaAsn-547 Hydrophilic Regions - Hopp-Woods 13-PheProLysArgCysGluSerGluTyrAsp-22 41-AlaAlaAspLysLeuLeuGlyGlyAspArgArgSerVal-53 74-GlyAspMetAspVal-78 85-AsnAspAsnGluMetSerIle-91 106-ValValArgAspMetHis-lll 123-LysValLeuAspLysIleProGly-130 134-PheAlaGlnLysValGluHisLysIleLysThrLeuAlaGluGluAlaGluHisAlaLysGln-154 181-ValLeuLysAspLeuArgSerArgLysGlyPro-191 197-IleThrLysLyεGlyAsnGly-203 205-LysLeuAlaGluAsnAspProValLys-213 220-LeuProLysGluGlyGlyAla-226 228-MetProSerGluLysGluProLysProAlaAla-238 253-ArgAlaAlaAlaAspSerArgLeu-260 266-AlaMetArgGluGlySerGly-272 274-ValGluPheGluGlnArgPheProAspArgTyrPhe-285 372-ProSerAspGluAsnGluCys-378 405-ProValSerAspGlyMetGluThrValGluIleGlyLysGlyIleIleArgArgGluGlyGluLysThrAla -428 457-LysProIleAspGluGluLeuIle-464 467-LeuAlaArgSerHisAspArgIleValThrLeuGluGluAsnAlaGluGlnGlyGly-485 511-ThrValThrGluHisGlyAspProLysLysLeuLeuAsp-523 530-GluAlaValGluArgArgValArgGluTrpLeuProAspArgAspAlaAlaAsn-547 g034 AMPHI Regions - AMPHI 35-LeuAspHisAlaAla-39 52-AsnLeuGluGlnMetArgAlaIleMetGluAlaAlaAspGln-65 94-AlaValGluGluPheProHisIlePro-102 152-ThrValValAsnPheSer-157 168-IleGlyValLeuGlyAsnLeuGluThrGly-177 197-LeuThrSerValGluAspAlaValArgPheValLysAspThrGly-211 226-TyrLysPheThrArgProProThrGly-234 236-ValLeuArgIleAspArgIleLysGluIleHisGlnAlaLeu-249 261-SerValProGlnGluTrpLeuLysValIleAsnGluTyrGlyGlyAsnIleGlyGluThrTyrGlyValPro ValGluGluIleValGluGlyIleLysHisGly-295 314-ArgArgTyrLeuAlaGluAsn-320 330-LeuGlyLysThrIleGluAlaMetLys-338 Antigenic Index - Jameson-Wolf 20-LeuProLysGluThrGln-25 37-HisAlaAlaGluAsnSerTyrGly-44 54-GluGlnMetArgAlaIleMetGluAlaAlaAspGlnVal-66 75-SerAlaGlyAlaArgLysTyrAla-82 106-HisGlnAspHisGlyAlaSerProAspValCysGlnArgSerIle-120 132-SerLeuLeuGluAspGlyLysThrProSerSerTyrGluTyr-145 164-ValGluGlyGluIle-168 173-AsnLeuGluThrGlyGluAlaGlyGluGluAspGlyValGlyAla-187 191-LeuSerHisAspGln-195 199-SerValGluAspAlaValArgPheValLysAεpThrGlyValAsp-213 221-ThrSerHisGlyAla-225 227-LyεPheThrArgProProThrGlyAεpValLeuArgIleAspArgIleLysGluIleHis-246 258-GlySerSerSerValPro-263 271-AsnGluTyrGlyGlyAsnIleGlyGlu-279 287-GluIleValGluGlyIleLysHisGlyValArgLysValAsnIleAspThrAspLeuArgLeuAlaSerThr GlyAlaVal-313 316-TyrLeuAlaGluAsnProSerAspPheAspProArgLysTyrLeuGlyLysThrIleGluAlaMetLys-33 8 350-CysGluGlyGlnAlaGlyLysIleLysProValSerLeuGluLysMetAlaSerArgTyrAlaLysGlyGlu Leu-374 Hydrophilic Regions - Hopp-Woods 54-GluGlnMetArgAlaIleMetGluAlaAlaAspGlnVal-66 76-AlaGlyAlaArgLysTyrAla-82 108-AspHisGlyAlaSerProAspValCysGln-117 132-SerLeuLeuGluAspGlyLysThrProSer-141 164-ValGluGlyGluIle-168 175-GluThrGlyGluAlaGlyGluGluAspGlyValGlyAla-187 199-SerValGluAspAlaValArgPheValLysAspThrGlyVal-212 235-AspValLeuArgIleAspArgIleLysGluIleHis-246 287-GluIleValGluGlyIleLysHisGlyValArgLysValAsnIleAspThrAspLeuArgLeu-307 320-AsnProSerAspPheAspProArgLysTyrLeu-330 333-ThrIleGluAlaMetLys-338 352-GlyGlnAlaGlyLysIleLyεProValSerLeuGluLysMetAlaSerArgTyrAlaLysGlyGluLeu-37 4 g036 AMPHI Regions - AMPHI 59-SerSerGlyArgPheCysGlnThrIleLysAlaAla-70 97-AlaAspGlyLeuGlnThrValSerSerAlaAla-107 142-AlaValArgArgValProArgGlnLeuArgAspΞerArg-154 215-CysArgThrThrHisLysThrLeuArgProTyrAlaArgProGlnArgArg-231 Antigenic Index - Jameεon-Wolf 16-ProAlaArgThrSerSerSerArgArgCysValProSerGlyArgCys-31 35-TyrSerSerArgAlaAspAlaThrProArgArgArgHisSerGlyAlaVal-51 55-CysSerSerAspSerSerGlyArgPhe-63 74-SerPheSerAlaArgLysThrCysSerAspGlyGluThrSerAlaAεpSerAsnTrpArg-93 109-AlaAlaGlnSerAspGlyGluAlaGlyArg-118 133-SerGlyArgPheCysCysGlyArgArgAlaValArgArgValProArgGlnLeuArgAspSerArgArgArg GlyArgAlaArgGluAsnArgArgArgSerAlaTyr-168 171-CyεLeuArgArgAlaAspGlyPheProVal-180 182-ThrHisCysArgCysArgLeuLysArgArgThrProArgGlyGlyGlnCys-198 200-ProProTyrArgLeuAspAsnArgSerAsnGlyGlyGlySerAlaCysArgThrThrHisLysThrLeuArg ProTyrAlaArgProGlnArgArgValCysSer-234 239-AlaAlaArgArgArgHisArgAlaTrpGlyCysArgLeuLysAlaCysArg-255 258-LeuProAsnLeuAlaProArgArgCysArgTyrAlaVal-270 Hydrophilic Regions - Hopp-Woods 17-AlaArgThrSerSerSerArgArgCysValPro-27 37-SerArgAlaAspAlaThrProArgArgArgHisSerGly-49 55-CysSerSerAspSerSerGlyArg-62 76-SerAlaArgLysThrCysSerAspGlyGluThrSerAla-88 110-AlaGlnSerAspGlyGluAlaGlyArg-118 137-CysCysGlyArgArgAlaValArgArgValProArgGlnLeuArgAspSerArgArgArgGlyArgAlaArg GluAsnArgArgArgSerAlaTyr-168 171-CysLeuArgArgAlaAspGlyPhePro-179 182-ThrHisCysArgCysArgLeuLysArgArgThrProArgGlyGlyGln-197 202-TyrArgLeuAspAsnArgSerAsnGlyGly-211 213-SerAlaCysArgThrThrHisLysThrLeuArgProTyrAlaArgProGlnArgArgValCys-233 239-AlaAlaArgArgArgHisArgAlaTrp-247 251-LeuLysAlaCysArg-255 262-AlaProArgArgCysArgTyrAlaVal-270 g038 AMPHI Regions - AMPHI 161-GlyLysLeuSerAlaValGlnGluValGluLys-171 178-AlaProIleAlaSerLeuAsn-184 195-GluPheGlyGlnPheLeuGluProValArgThrTyrArgArgGlnTyrGlyVal-212 Antigenic Index - Jameεon-Wolf 2-ThrAεpPheArgGlnAspPhe-8 22-GluPheThrThrLysAlaGlyArgArgSerPro-32 38-GlyLeuPheAεnAεpGlyAlaSer-45 58-IleGluSerGlyIleArg-63 85-LeuAlaGluLysGlyVal-90 96-TyrAsnArgLysGluAlaLysAspArgGlyGluGlyGlyVal-109 125-ValIleSerAlaGlyThrSerValArgGluSerIleLysLeuIleGluAlaGluGlyAlaThr-145 153-LeuAspArgMetGluLysGlyThrGlyLysLeuSerAla-165 167-GlnGluValGluLysGlnTyrGlyLeu-175 191-GlnAsnAsnProGluPheGlyGln-198 201-GluProValArgThrTyrArgArgGlnTyrGlyValGlu-213 Hydrophilic Regions - Hopp-Woods 2-ThrAspPheArgGlnAspPhe-8 22-GluPheThrThrLyεAlaGlyArgArgSer-31 85-LeuAlaGluLysGlyVal-90 96-TyrAsnArgLysGluAlaLysAspArgGlyGluGly-107 130-ThrSerValArgGluSerIleLysLeuIleGluAlaGluGlyAlaThr-145 153-LeuAspArgMetGluLysGlyThrGlyLys-162 167-GlnGluValGluLysGlnTyr-173 204-ArgThrTyrArgArgGlnTyrGly-211 g040 AMPHI Regions - AMPHI 6-SerPheValAlaHisPhe-ll 14-AlaAlaProTyrIleArgGlnMetArgGlyThr-24 38-GlyThrLeuAsnLysLeu-43 65-HisPheLeuAspArg-69 78-ProHisTyrCysArgGlyLeuArgValThrAspGluThr-90 95-AlaGlnGlnPheAlaGly-100 113-SerValSerGlyPheAlaArgAlaPro-121 136-MetGlyValIleAsp-140 146-TyrAlaGlyValIleArg-151 207-LeuSerAspGlyIleSerArgProAspGlyThrLeuAlaGlu-220 223-SerAlaGlnGluAlaGlnSerLeuAlaGluHisAla-234 244-SerAlaValAlaAlaLeuGluGly-251 277-IleGlyThrSerIle-281 289-IleArgGlnAlaHisSerGlyAspIleProHisIleAlaAlaLeuIleArgProLeuGlu-308 320-TyrLeuGluAsnHisIleSerGluPheSerIle-330 338-TyrGlyCysAlaAlaLeuLysThrPheAlaGluAlaAsp-350 371-ArgLeuLeuAlaHisIle-376 386-SerArgLeuPheAla-390 Antigenic Index - Jameson-Wolf 2-AsnAlaProAspSer-6 H-PheArgGluAlaAlaProTyrIleArgGlnMetArgGlyThrThr-25 29-GlyIleAspGlyArgLeuLeuGluGlyGlyThr-39 74-GlnGlyArgThrProHisTyrCysArgGlyLeuArgValThrAspGluThrSerLeuGlyGln-94 101-ThrValArgSerArgPheGlu-107 119-ArgAlaProSerVal-123 134-ArgProMetGlyVal-138 140-AspGlyThrAspMetGluTyr-146 150-IleArgLysThrAspThrAlaAla-157 162-LeuAspAlaGlyAsn-166 173-LeuGlyHisSerTyrGlyGlyLysThrPheAsn-183 208-SerAspGlyIleSerArgProAspGlyThrLeuAla-219 222-LeuSerAlaGlnGluAlaGlnSerLeuAla-231 234-AlaAlaSerGluThrArgArgLeuIle-242 249-LeuGluGlyGlyVal-253 261-GlyAlaAlaAspGlySerLeuLeu-268 272-PheThrArgAsnGlyIleGlyThrSerIleAlaLyεGluAla-285 290-ArgGlnAlaHisSerGlyAspIle-297 305-ArgProLeuGluGluGlnGly-311 315-HisArgSerArgGluTyrLeu-321 329-SerIleLeuGluHisAspGlyAspLeuTyr-338 345-ThrPheAlaGluAlaAspCysGlyGlu-353 361-ProGlnAlaGlnAspGlyGlyTyrGlyGluArgLeu-372 377-IleAspLysAlaArgGly-382 393-ThrAsnThrGlyGlu-397 402-ArgGlyPheGlnThrAlaSerGluAspGluLeuProGluThrArgArgLysAspTyrArgSerAsnGlyArg AsnProHisIleLeu-430 Hydrophilic Regions - Hopp-Woods ll-PheArgGluAlaAlaPro-16 30-IleAspGlyArgLeuLeuGlu-36 84-LeuArgValThrAspGluThrSerLeu-92 102-ValArgSerArgPheGlu-107 140-AspGlyThrAspMetGluTyr-146 150-IleArgLyεThrAspThrAlaAla-157 210-GlyIleSerArgProAspGlyThrLeu-218 222-LeuSerAlaGlnGluAlaGlnSerLeuAla-231 234-AlaAlaSerGluThrArgArgLeuIle-242 291-GlnAlaHisSerGlyAsp-296 305-ArgProLeuGluGluGlnGly-311 315-HisArgSerArgGluTyrLeu-321 332-GluHisAspGlyAspLeu-337 345-ThrPheAlaGluAlaAspCysGlyGlu-353 362-GlnAlaGlnAspGlyGlyTyrGlyGlu-370 377-IleAspLysAlaArgGly-382 402-ArgGlyPheGlnThrAlaSerGluAspGluLeuProGluThrArgArgLysAspTyrArgSerAsnGlyArg Asn-426 g041-l AMPHI Regions - AMPHI 6-AspProTyrArgHisPheGluAsnLeuAspΞerAlaGluThr-19 45-AspGlyIleLeuAsnGlnMetGlnAsp-53 77-ProLysGlyValTyrArgMetCysThrAlaAla-87 102-ValAlaAspPheAspGluLeuLeu-109 117-GlyValSerHisLeuValGluGlnProAsn-126 218-MetValAsnAlaTrpArgTyrLeuAsp-226 232-IleAspLeuIleGluAlaSer-238 257-ProLeuAsnLeuProAsnAspCysAεpValValGlyTyrLeu-270 317-GlnAlaLeuGluSerValGluThr-324 331-AlaSerLeuLeuGluAεnValGlnGlyArg-340 382-AspPheThrThrProLeu-387 451-GlyPheGlyIleProGluLeuProHisTyrLeuGlySerValGlyLys-466 493-AlaAlaGlnGlyIleSerLyεHisLysSerValAspAspLeuLeuAlaValValArgAspLeuSerGluArg -516 519-SerSerProLysHis-523 541-ValArgGluProGlnSer-546 556-LeuThrAspMetIleArgTyr-562 571-TrpThrAspGluTyrGlyAsnProGlnLysTyrGluAlaCysLysArgArgLeuGly-589 591-LeuSerProTyrHisAsnLeuSerAspGlyIleAspTyrProPro-605 620-AlaHisAlaLeuLys-624 645-GlyHisThrGlyAsn-649 651-ThrGlnArgGluSer-655 Antigenic Index - Jameson-Wolf l-MetLysSerTyrProAspProTyrArgHiεPheGluAsnLeuAspSerAlaGluThrGln-20 26-AlaAsnAlaGluThrArgAlaArgPheLeuAsnAsnAspLysAlaArgAlaLeuSerAspGlyIle-47 51-MetGlnAspThrArgGlnIleProPhe-59 61-GlnGluHisArgAlaArg-66 72-GlnAsnAlaGluTyrProLysGlyVal-80 89-TyrArgSerGlyTyrProGluTrp-96 104-AspPheAspGluLeuLeuGlyAspAspValTyr-114 123-GluGlnProAsnArg-127 132-LeuAsnLysSerGlyGlyAspThr-139 145-ValAspLeuGluAlaGlyGluLeuValGlu-154 161-AlaGlyLysAεnHisValSerTrpArgAspGluAsnSerVal-174 178-ProAlaTrpAspGluArgGlnLeuThrGluSerGlyTyrProArgGluValTrpLeuValGluArgGlyLys SerPheGluGluSerLeuPro-208 211-GlnIleAspLysGlyAla-216 223-ArgTyrLeuAspProGlnGlySerProIleAspLeuIleGluAlaSerAspGlyPheTyr-242 249-ValSerSerGluGlyGlyAlaLysProLeuAsnLeuProAsnAspCysAεpVal-266 278-LeuArgLysAspTrpHisArgAlaAsnGlnSerTyrProSer-291 298-LysLeuAsnArgGlyGluLeuGly-305 313-ProAspGluThrGlnAla-318 320-GluSerValGluThrThrLys-326 337-ValGlnGlyArgLeuLysAla-343 345-ArgPheAlaAspSerLysTrpGlnGluAlaGluLeuProHisLeuProSerGly-362 365-GluMetThrAspGlnProTrpGlyGly-373 405-GlnProGlnGlnPheValSerAspGlyIleGluVal-416 422-ValSerSerAspGlyGluArgIle-429 435-GlyLysAsnAlaAlaProAspThr-442 479-Asnl1eArgGlyGlyGlyGluPheGlyProArgTrpHis-491 496-GlyIleSerLysHisLysSerValAspAsp-505 511-ArgAspLeuSerGluArgGlyMetSerSerProLyεHis-523 528-GlyGlySerAsnGly-532 540-PheValArgGluProGlnSerIleGlyAla-549 568-GlySerSerTrpThrAspGluTyrGlyAsnProGlnLysTyrGluAlaCysLysArgArgLeuGlyGluLeu SerProTyr-594 596-AsnLeuSerAspGlyIleAspTyrPro-604 610-ThrSerLeuSerAspAspArgValHiε-618 627-AlaLysLeuArgGluThrSerProGlnSer-636 639-TyrSerProAspGlyGlyGlyHisThrGlyAsnGlyThrGlnArgGluSerAlaAspLysLeu-659 Hydrophilic Regions - Hopp-Woods 3-SerTyrProAspProTyrArgHis-10 12-GluAsnLeuAspSerAlaGluThr-19 26-AlaAsnAlaGluThrArgAlaArgPheLeuAsnAsnAspLysAlaArgAlaLeuSer-44 51-MetGlnAspThrArgGln-56 61-GlnGluHisArgAlaArg-66 104-AspPheAspGluLeuLeuGly-110 134-LysSerGlyGlyAsp-138 145-ValAspLeuGluAlaGlyGluLeuValGlu-154 166-ValSerTrpArgAεpGluAsnSer-173 180-TrpAspGluArgGlnLeuThr-186 198-GluArgGlyLysSerPheGluGluSerLeu-207 211-GlnIleAspLysGlyAla-216 233-AspLeuIleGluAlaSerAsp-239 250-SerSerGluGlyGlyAlaLys-256 278-LeuArgLysAspTrpHisArg-284 298-LysLeuAsnArgGlyGluLeuGly-305 313-ProAspGluThrGlnAla-318 320-GluSerValGluThrThrLys-326 337-ValGlnGlyArgLeuLysAla-343 347-AlaAspSerLysTrpGlnGluAlaGluLeu-356 412-AspGlyIleGluVal-416 424-SerAspGlyGluArg-428 436-LysAsnAlaAlaProAsp-441 481-ArgGlyGlyGlyGluPheGly-487 496-GlyIleSerLysHisLysSerValAspAsp-505 511-ArgAspLeuSerGluArgGlyMetSerSer-520 540-PheValArgGluProGlnSer-546 571-TrpThrAspGluTyrGlyAsn-577 579-GlnLysTyrGluAlaCysLysArgArgLeuGlyGlu-590 612-LeuSerAspAspArgValHis-618 627-AlaLysLeuArgGluThrSer-633 650-GlyThrGlnArgGluSerAlaAspLysLeu-659 g042 AMPHI Regions - AMPHI 18-LeuSerAsnThrSerThr-23 33-AlaValArgSerMet-37 138-SerProLeuValArgIleLeuProLeuSer-147 151-SerMetValValAlaPhePheAlaAsn-159 Antigenic Index - Jameson-Wolf 16-SerAlaLeuSerAsnThrSerThrAlaAlaGlyProSerCys-29 49-TyrSerLysGluThrGlyCysProCysProSerLeuArgLysAspSerSerThrGlyGlyArgProMetSerP roCys-74 77-LeuAlaAsnArgAspCysValProLysAlaAspThr-88 93-ThrAspSerThrSerProArgProLeu-101 109-TrpAlaAsnSerAlaSer-114 120-SerAlaThrArgAlaSerLeuProLysIleArgAspArgVal-133 160-CysSerTyrAlaSerAlaProGlyPro-168 175-GlyLeuTrpArgCysArgAspSerGlnSerGlySerAsnSer-188 197-AsnAlaGlyCysLys-201 Hydrophilic Regions - Hopp-Woods 49-TyrSerLysGluThrGlyCys-55 59-SerLeuArgLysAspSerSerThrGlyGlyArgProMet-71 78-AlaAsnArgAspCysValProLysAlaAspThr-88 94-AspSerThrSerProArg-99 122-ThrArgAlaSerLeuProLysIleArgAspArgVal-133 178-ArgCysArgAspSerGlnSerGly-185 g043-2 AMPHI Regions - AMPHI 21-GluArgPheValGluProSerArg-28 34-LysValHisArgGlyLeuAspGlyAlaAlaArgPheAspGluGlyGluArg-50 59-AlaSerGlyAspGlyPhe-64 81-AspAlaAlaGlyAspPheGlyAspGlyGlnArg-91 98-GlnAsnIleGlyGlyPheValTyr-105 Antigenic Index - Jameεon-Wolf l-MetProSerAlaPro-5 12-ArgArgGlnLysSerValMetProProGluArgPheValGluProSerArg-28 34-LysValHisArgGlyLeuAspGlyAlaAlaArgPheAspGluGlyGluArgValPhe-52 56-AlaAlaGlnAlaSerGlyAspGlyPheAla-65 79-GlnProAspAlaAlaGlyAεpPheGlyAspGlyGlnArgAlaGlyGlu-94 116-AlaGluGlyGluAla-120 Hydrophilic Regions - Hopp-Woodε 12-ArgArgGlnLysSerValMetProProGluArgPheValGluProSerArg-28 34-LysValHisArgGlyLeuAspGlyAlaAlaArgPheAspGluGlyGluArgValPhe-52 81-AspAlaAlaGlyAspPheGlyAspGlyGlnArgAlaGlyGlu-94 116-AlaGluGlyGluAla-120 g046 AMPHI Regions - AMPHI 6-ArgProThrSerSerPro-ll 46-ThrSerCysSerGlyLeuMetValSer-54 64-PheSerLeuPheSerSer-69 113-LyεSerAlaSerSer-117 143-SerCysAsnAlaPheSerSer-149 Antigenic Index - Jameson-Wolf 6-ArgProThrSerSerProProArgArgAlaCys-16 20-IleArgThrArgSerSerAlaLysArgLysThrCysAsnAlaProGlyGlnSerIleArgProAlaSerCysS er-44 57-ProAsnMetGluArgLeuPro-63 75-SerArgTyrSerLeuGluArgThrArgAlaMetArgProGlyMetLeuAεnArgSerAlaAla-95 105-SerLeuArgGluSerAlaSerSerLysSerAlaSerSerAlaProAlaArgTyrAsnValLysGlyAspAla ProLeuPro-131 133-ThrValTrpThrSerArgArgLeuProVal-142 169-GluProThrCysProLeuProLys-176 Hydrophilic Regions - Hopp-Woods 7-ProThrSerSerProProArgArgAlaCys-16 20-11eArgThrArgSerSerAlaLysArgLysThrCysAsn-32 36-GlnSerIleArgProAlaSer-42 58-AsnMetGluArgLeuPro-63 75-SerArgTyrSerLeuGluArgThrArgAlaMetArg-86 105-SerLeuArgGluSerAlaSerSerLysSerAlaSer-116 122-TyrAsnValLysGlyAspAlaProLeu-130 g047 AMPHI Regions - AMPHI 17-IleAlaAspIleAlaGlnAspLeuProAspGlyAla-28 62-AlaGluAsnIleGlyAlaVal-68 89-AsnIleCysTyrArgLeuAlaLysGlnLeuGlu-99 141-TyrIleAspGluIleAspValPhe-148 161-SerAlaLeuLeuAla-165 185-LeuLeuGluGlyAsn-189 202-IleGlySerIleLeuAla-207 247-SerGlyIleLysTrpProGluGlyCys-255 257-IleAlaAlaValValArgAlaGlyThrGly-266 293-IleLeuAsnGluLeuGluLysLeuIle-301 Antigenic Index - Jameson-Wolf 5-GlnAlaArgArgGlyGlyLeuLeu-12 20-IleAlaGlnAspLeuProAspGlyAlaAsp-29 36-TyrArgAsnAsnArgLeu-41 51-IleGluGlyAspGlu-55 70-ProGluLeuArgProLysGluThrSerThrArgArgIleMet-83 96-LysGlnLeuGluHis-100 106-IleIleGluCysArgProArgArgAlaGluTrpIle-117 119-GluAsnLeuAspAsnThrLeu-125 130-SerAlaThrAspGluThrLeuLeuAspAsnGluTyrIleAspGluIleAsp-146 152-ThrAsnAspAspGluSerAsnIle-159 168-LeuGlyAlaLysArgVal-173 178-AsnArgSerSerTyr-182 186-LeuGluGlyAsnLysIle-191 208-HisIleArgArgGlyAspIleVal-215 219-ProIleArgArgGlyThrAlaGluAlaIleGlu-229 232-AlaHisGlyAspLysLysThrSer-239 242-IleGlyArgArgIleSerGlyIleLysTrpProGluGlyCysHis-256 262-ArgAlaGlyThrGlyGluThr-268 277-ValIleGlnAspGlyAspHis-283 288-ValSerArgArgArgIleLeuAsnGluLeuGluLys-299 Hydrophilic Regions - Hopp-Woodε 5-GlnAlaArgArgGlyGly-10 20-IleAlaGlnAspLeuProAspGlyAlaAsp-29 51-IleGluGlyAspGlu-55 70-ProGluLeuArgProLysGluThrSerThrArgArglleMet-83 106-IleIleGluCysArgProArgArgAlaGluTrpIle-117 130-SerAlaThrAspGluThrLeuLeu-137 140-GluTyrIleAspGluIleAsp-146 152-ThrAsnAspAspGluSerAsnIle-159 168-LeuGlyAlaLysArgVal-173 186-LeuGluGlyAsnLysIle-191 209-IleArgArgGlyAspIle-214 219-ProIleArgArgGlyThrAlaGluAlaIleGlu-229 232-AlaHisGlyAspLysLysThrSer-239 242-IleGlyArgArgIleSer-247 277-ValIleGlnAspGlyAsp-282 289-SerArgArgArgIleLeuAsnGluLeuGluLys-299 g049-2 AMPHI Regions - AMPHI 15-GlnHisLeuLeuGlu-19 34-AspHisAlaValAspGlyIleGlyGlnMet-43 50-GlnProPheGlyGln-54 61-GluHisPheAlaProValAspGlyPheArg-70 103-IleGlyValPheProAlaLeu-109 199-SerAspPheArgArg-203 217-AlaArgLeuThrGlnValPheGlnAlaPhePhe-227 241-ValLeuAsnLeuCysArgArgAla-248 Antigenic Index - Jameson-Wolf 6-PheAspTyrArgThrArgLeu-12 21-IleSerLysGluArgHis-26 31-ArgArgThrAspHisAlaValAspGly-39 49-AspGlnProPheGly-53 64-AlaProValAspGlyPheArgValGlnAspIleAspLeuAspGlyHisGlnArgLeuPhe-83 90-PheArgAsnProValCysArgArgThrGlyPhe-100 122-GlyIleGluProAspSerProProArgPhe-131 135-PheArgAsnArgHisLeuGlnGlySerLeuArgVal-146 150-PheLeuLysAspAspHisArgValGly-158 199-SerAspPheArgArgPheGlyGlnArgHisIleGlyArgArgGlyIleHis-215 244-LeuCysArgArgAlaAsnProArgProLysArgSerLeu-256 Hydrophilic Regions - Hopp-Woods 21-IleSerLysGluArgHis-26 31-ArgArgThrAspHisAlaVa1-37 67-AspGlyPheArgValGlnAspIleAspLeuAspGlyHisGlnArgLeuPhe-83 93-ProValCysArgArgThrGlyPhe-100 124-GluProAspSerProProArg-130 150-PheLeuLysAspAspHisArgVal-157 200-AspPheArgArgPheGlyGln-206 208-HisIleGlyArgArgGlyIleHis-215 244-LeuCysArgArgAlaAsnProArgProLysArgSerLeu-256 g050-l AMPHI Regions - AMPHI lO-IleGlnSerIleCysAspAlaPheGlnPheIleSerTyrTyr-23 25-ProLysAspTyr11eAspAlaLeuTyrLysAlaTrpGlnLys-38 94-ValAsnGluGlyVal-98 163-AsnProSerAspAsnIleValAspTrpValLeuLys-174 177-ProThrMetGlyAla-181 235-LeuGluLeuPheGluLysValAsnAla-243 250-GlyLeuGlyGlyLeuThrThr-256 275-AlaMetIleProAsn-279 315-AsnGlyLysArgValAspValAsp-322 353 -LysArgLeuValAsMetLeuAspLys-361 367-ValAspPheThrAsnArgLeu-373 379-ProValAspProValGlyAspGlu-386 396-AlaThrArgMetAspLysPheThrArgGlnMet-406 452-LysSerSerLysValLeuAlaPhe-459 490-AlaThrAlaProArgLysTrp-496 Antigenic Index - Jameson-Wolf 4-IleLysGlnGluAspPheIle-10 23-TyrHisProLysAspTyrIleAspAlaLeu-32 36-TrpGlnLysGluGluAsnProAlaAlaLysAspAlaMet-48 55-SerArgMetCysAlaGluAsnAsnArgProIleCysGlnAspThrGly-70 88-MetSerValGluLysMetValAsnGluGlyValArgArgAlaTyrThrTrpGluGlyAsnThrLeuArgAlaS erVal-113 116-AspProAlaGlyLysArgGlnAsnThrLysAspAsnThr-128 138-ProGlyGlyLysValGluVal-144 148-AlaLysGlyGlyGlySerGluAsnLysSerLysLeu-159 163-AsnProSerAspAsnIle-168 192-GlyIleGlyGlyThrProGluLysAlaValLeuMetAlaLysGluSerLeu-208 213-AspIleGlnGluLeuGlnGluLysAlaAlaSerGlyAlaGluLeuSerThr-229 284-ArgHisValGluPheGluLeuAspGlySerGlyProValGluLeuThrProProArgValGluAspXxxPro AspLeuThrTyrSerProAspAsnGlyLysArgValAspValAspLysLeuThrLysGluGluValAlaSer LysThrGlyAsp-336 345-LeuThrGlyArgAspAlaAlaHisLysArgLeu-355 359-LeuAspLysGlyGluGluLeuPro-366 379-ProValAspProValGlyAspGluValValGlyProAlaGlyProThrThrAlaThrArgMetAspLysPhe ThrArgGlnMetLeu-407 416-IleGlyLysSerGluArgGlyAlaAlaThr-425 428-AlaIleAlaAspAsnLysAla-434 450-AlaIleLysSerSerLys-455 470-PheGluValLysAspMetPro-476 481-ValAspSerLysGlyGluSerIle-488 492-AlaProArgLysTrpGlnAla-498 Hydrophilic Regions - Hopp-Woods 4-IleLysGlnGluAspPheIle-10 36-TrpGlnLysGluGluAsnProAlaAlaLysAεpAlaMet-48 57-MetCysAlaGluAsnAsnArgProIleCys-66 88-MetSerValGluLysMetValAsnGluGlyValArgArg-100 117-ProAlaGlyLysArgGlnAsnThrLysAspAsnThr-128 140-GlyLyεValGluVal-144 148-AlaLysGlyGlyGlySerGluAsnLysSerLysLeu-159 195-GlyThrProGluLysAlaValLeuMetAlaLysGluSerLeu-208 213-AspIleGlnGluLeuGlnGluLysAlaAlaSer-223 225-AlaGluLeuSerThr-229 284-ArgHisValGluPheGluLeuAspGly-292 299-ThrProProArgValGluAspXxxProAsp-308 313-ProAspAsnGlyLysArgValAspValAspLysLeuThrLysGluGluValAlaSer-331 345-LeuThrGlyArgAspAlaAlaHisLysArgLeu-355 359-LeuAspLysGlyGluGluLeuPro-366 382-ProValGlyAspGluValVal-388 397-ThrArgMetAεpLysPheThrArgGlnMetLeu-407 417-GlyLysSerGluArgGlyAlaAlaThr-425 428-AlaIleAlaAspAsnLysAla-434 450-AlaIleLysSerSerLys-455 470-PheGluValLysAspMetPro-476 481-ValAspSerLysGlyGluSerIle-488 492-AlaProArgLysTrpGlnAla-498 g052 AMPHI Regions - AMPHI 12-AlaProCysPheLysGlyCysGluProThrGlyAsp-23 41-AlaLysAlaSerLysΞerAlaThrSerProLysGlyLeuAεpGlyValSerLys-58 67-ThrAlaAlaPheHisSerPheIleSer-75 84-MetProAsnLeuValThrMetLeu-91 Antigenic Index - Jameson-Wolf 4-ValAlaGluGluThrGluIle-10 14-CysPheLyεGlyCysGluProThrGlyAspSerArgLeuLeuSerThrThrLysSerAlaPro-34 37-CysAlaAsnSerAlaLysAlaSerLysSerAlaThrSerProLysGlyLeuAspGlyValSerLysAsnSerS er-61 75-SerValGlyAspThrArgLeuThrProMet-84 97-ValValProAsnArgLeuArgLeuGluThrThrTrpSerProAlaCysArgLysValLysAsnAlaAla-119 Hydrophilic Regions - Hopp-Woods 4-ValAlaGluGluThrGluIle-10 16-LysGlyCysGluProThrGlyAspSerArgLeu-26 30-ThrLysSerAlaPro-34 39-AsnSerAlaLysAlaSerLysSerAlaThrSerProLysGlyLeuAspGlyValSerLysAsnSer-60 77-GlyAspThrArgLeu-81 100-AsnArgLeuArgLeu-104 lll-AlaCysArgLysValLysAsnAlaAla-119 g075-2 AMPHI Regions - AMPHI 15-LysSerAlaAlaLysThrProThrThrIleGlnProAlaSerIleProSer-31 65-AlaProTyrLeuArgGlnValLeu-72 80-PheLysLysCysLeuAla-85 92-PheArgArgProProAsn-97 114-ValAlaAspPhePheGlnThrCysValAsnArgPhePheGluValValGluIleIleGlyIleGly-135 Antigenic Index - Jameson-Wolf 12-GluAsnThrLysSerAlaAlaLysThrProThr-22 25-GlnProAlaSerIlePro-30 52-AlaLysAlaSerGly-56 90-GluPhePheArgArgProProAsnIleArgLysSerValPheGlnLysSerGluTyrAspLys-110 Hydrophilic Regions - Hopp-Woods 12-GluAsnThrLysSerAlaAlaLysThr-20 52-AlaLysAlaSerGly-56 90-GluPhePheArgArgProProAsnIleArgLysSerValPheGlnLysSerGluTyrAspLys-110 g080-2 AMPHI Regions - AMPHI 6-GluAlaMetGluArgLeuThrArg-13 95-PheProAspThrValGlu-100 108-ProValAlaArgTrpGlyAspHis-115 144-SerAlaGluMetLeuArgArgTyrAspGluPheSerThrValLeu-158 195-LysArgLeuArgLeuPheThrGluAlaTrpGlnHis-206 Antigenic Index - Jameson-Wolf l-MetTrpAspAsnAlaGluAlaMetGluArgLeuThr-12 33-AsnSerAsnHisLeuPro-38 42-ValSerLeuLysGly-46 50-TyrSerAspLysLysAlaLeu-56 67-AsnIleLeuArgThrAspIleAsnGlyAlaGlnGluAlaTyr rg-81 90-MetValArgArgArgPheProAspThrValGlu-100 103-LeuThrGluArgLysProValAlaArgTrpGly-113 116-AlaLeuValAspGlyGluGlyAsnValPhe-125 127-AlaArgLeuAεpArgProGlyMetPro-135 138-ArgGlyAlaGluGlyThrSer-144 146-GluMetLeuArgArgTyrAspGlu-153 163-LeuGlyIleLysGlu-167 180-LeuAspAsnGlyIle-184 187-ArgLeuGlyArgGluAsnGluMetLysArgLeuArgLeu-199 207-LeuLeuArgLysAsnLysAsnArgLeuSer-216 220-MetArgTyrLysAspGlyPheSerVal-228 230-HisAlaProAspGlyLeuProGluLysGluSerGluGlu-242 Hydrophilic Regions - Hopp-Woods 3-AεpAsnAlaGluAlaMetGluArgLeuThr-12 50-TyrSerAspLysLysAlaLeu-56 69-LeuArgThrAspIleAsnGlyAlaGlnGluAlaTyrArg-81 90-MetValArgArgArgPheProAspThrVal-99 103-LeuThrGluArgLysProValAlaArgTrpGly-113 116-AlaLeuValAspGlyGluGlyAsnValPhe-125 127-AlaArgLeuAspArgProGly-133 138-ArgGlyAlaGluGlyThrSer-144 146-GluMetLeuArgArgTyrAspGlu-153 163-LeuGlyIleLysGlu-167 187-ArgLeuGlyArgGluAsnGluMetLysArgLeuArgLeu-199 208-LeuArgLysAsnLysAsnArgLeuSer-216 220-MetArgTyrLysAspGlyPheSer-227 230-HisAlaProAspGlyLeuProGluLysGluΞerGluGlu-242 g081 AMPHI Regions - AMPHI 22-LysProValSerArgIleValThrAspSerArgAspIleArg-35 54-ValGlyGlyValLeuSer-59 78-AlaLeuLysValAspAsp-83 85-LeuAlaAlaLeuGlnThrLeuAlaLysAlaTrpArgAspAsn-98 116-LysGluMetLeuAlaAlaValLeuArg-124 130-AspAlaValSerAla-134 165-MetAsnHisPheGlyGluLeuAlaValLeuThrGlnIleAlaLys-179 186-AsnAsnAlaLeuArg-190 198-AspGlyValGlyAspIleAlaLysAla-206 303-LeuAsnAspValAlaGluGlyLeuGlnGlyPheSerAsn-315 345-AlaAlaValAspValLeuAlaArgMetPro-354 360-ValMetGlyAspMetGlyGluLeuGlyGlu-369 399-ValGluAlaAlaGlu-403 Antigenic Index - Jameson-Wolf 15-LeuProMetProSerGluAsnLysProValSer-25 27-IleValThrAspSerArgAspIleArgGluGlyAsp-38 44-AlaGlyGlyArgPheAspAla-50 67-ValSerArgGluAspCysAla-73 79-LeuLysValAspAspThrLeu-85 94-AlaTrpArgAspAsnValAsnProPhe-102 102-GlySerGlyGlyLysThrThrValLysGluMetLeu-119 123-LeuArgArgArgPheGlyAspAspAlaVal-132 138-AsnPheAsnAsnHisIle-143 151-LysLeuAsnGluLysHisArg-157 178-AlaLysProAspAla-182 194-GlyCysGlyPheAspGlyValGlyAspIleAlaLysAlaLysSerGluIle-210 223-ProGlnGluAspAlaAsn-228 245-GlyValAspSerGlyAspValArgAlaGluAsnIleVal-257 269-CysGlyAspGluArgThrAla-275 280-ValProGlyArgHisAsnVal-286 314-SerAsnIleLysGlyArgLeuAsnVal-322 330-ThrLeuIleAspAspThrTyrAsnAlaAsnProAspSerMetLysAlaAlaVal-347 363-AspMetGlyGluLeuGlyGluAspGluAlaAla-373 381-AlaTyrAlaArgAspGlnGlyIle-388 395-GlyAspAsnSerValGluAlaAlaGluLysPheGlyAla-407 425-AspLeuProGluArgAlaThrVal-432 434-ValLysGlySerArg-438 443-GluGluValValGluAlaLeuGluAspLys-452 Hydrophilic Regions - Hopp-Woods 17-MetProSerGluAsnLysProValSer-25 27-IleValThrAspSerArgAspIleArgGluGlyAsp-38 46-GlyArgPheAspAla-50 67-ValSerArgGluAspCysAla-73 79-LeuLysValAspAspThrLeu-85 94-AlaTrpArgAspAsnVal-99 109-SerGlyGlyLysThrThrValLysGluMetLeu-119 123-LeuArgArgArgPheGlyAspAspAlaVal-132 151-LysLeuAsnGluLysHisArg-157 178-AlaLysProAεpAla-182 199-GlyValGlyAspIleAlaLysAlaLysSerGluIle-210 223-ProGlnGluAspAlaAsn-228 247-AspSerGlyAεpValArgAlaGluAsnIleVal-257 269-CysGlyAspGluArgThrAla-275 316-IleLyεGlyArgLeuAsnVal-322 335-ThrTyrAsnAlaAsnProAspSerMetLysAlaAlaVal-347 363-AspMetGlyGluLeuGlyGluAspGluAlaAla-373 381-AlaTyrAlaArgAspGlnGlyIle-388 397-AsnSerValGluAlaAlaGluLysPheGlyAla-407 425-AspLeuProGluArgAlaThrVal-432 443-GluGluValValGluAlaLeuGluAspLys-452 g084-2 AMPHI Regions - AMPHI 6-Argl1eLysAsnMetAspGlnThrLeuLysAsnThrLeuGly-19 21-CysAlaLeuLeuAla-25 48-AlaValGlyAlaLeuAla-53 65-PheProArgValSer-69 96-GlnIleValGlySerIleLeuGluSer-104 111-GluPheValGlyAsnLeuProGly-118 Antigenic Index - Jameson-Wolf l-MetLysGlnSerAlaArgIleLysAsnMetAspGlnThrLeuLysAsnThr-17 40-TyrGluTyrGlyTyrArgTyrSer-47 102-LeuGluSerAsnProAlaGluAlaArgGluPheValGly-114 Hydrophilic Regions - Hopp-Woods l-MetLysGlnSerAlaArgIleLysAsnMetAspGlnThrLeu-14 105-AsnProAlaGluAlaArgGluPheVal-113 g085-2 AMPHI Regions - AMPHI 41-GluArgValAlaGlnIleGlyLysMetPheAspGlyLeu-53 60-LeuLysAspAlaLeuAspAsnGlyPheAsp-69 90-AsnGlyGlyArgValLeuGlyAspIleGluLeuLeuAlaAspIle-104 125-ThrSerLeuValGlyTyr-130 141-IleAlaGlyAsnIleGlyThr-147 174-GluAsnThrGluSerLeu-179 191-GluAspHisLeuAspArgTyrAspAspLeuLeuAspTyr-203 213-GlyAspGlyValGln-217 225-PheCysArgAlaMetLysArgAlaGlyArgGluVal-236 275-HisAsnAlaAlaAsnValMetAlaAlaValAlaLeuCysGluAla-289 300-HisValLysThrPheGlnGlyLeuProHisArgValGluLysIleGly-315 336-AlaAlaIleAlaGlyLeu-341 353-GlyLysGlyGlnAspPheThr-359 394-ThrAspCysValThrLeuGluGluAlaValGlnThr-405 424-SerPheAspMetPheLysGlyTyr-431 Antigenic Index - Jameson-Wolf 4-GlnAsnLysLysIleLeu-9 23-TyrLeuArgLysAsnGlyAlaGluValAlaAlaTyrAspAlaGluLeuLysAlaGluArgValAlaGln-45 58-GlyArgLeuLysAspAlaLeuAspAsnGlyPhe-68 74-SerProGlyIleSerGluArgGlnProAspIleGluAlaPheLysGlnAsnGlyGlyArgValLeuGly-96 104-IleValAsnArgArgGlyAspLysVal-112 116-ThrGlySerAsnGlyLysThrThr-123 150-LeuGluAlaGluLeuGlnArgGluGlyLysLysAlaAsp-162 169-SerSerPheGlnLeuGluAsnThrGluSerLeuArgProThrAla-183 189-1leSerGluAεpHiεLeuAspArgTyrAεpAspLeuLeu-201 204-AlaHisThrLysAlaGluIlePheArgGlyAspGlyVal-216 220-AsnAlaAspAspValPhe-225 228-AlaMetLysArgAlaGlyArgGluValLysArgPheSerLeuGluHisGluAla-245 251-ArgGlyThrGlyCysLeuLysGlnGlyAsnGluAspLeuIleSerThrGlnAspIlePro-270 291-GlyLeuProArgGluAlaLeu-297 307-LeuProHisArgValGluLysIleGlyGluLysAsnGly-319 322-PheIleAεpAεpSerLysGlyThrAsnVal-331 351-GlyMetGlyLysGlyGlnAspPheThrProLeuArgAspAlaLeuLysAspLysAlaLys-370 378-AspAlaProGlnIleArgArgAspLeuAspGlyCysGly-390 397-ValThrLeuGluGluAlaVal-403 431-TyrAlaHisArgSer-435 Hydrophilic Regions - Hopp-Woods 4-GlnAsnLysLysIleLeu-9 25-ArgLysAsnGlyAlaGlu-30 32-AlaAlaTyrAspAlaGluLeuLysAlaGluArgValAlaGln-45 59-ArgLeuLysAspAlaLeuAspAsnGlyPhe-68 77-IleSerGluArgGlnProAspIleGluAlaPheLysGlnAsnGlyGly-92 104-IleValAsnArgArgGlyAspLysVal-112 118-SerAsnGlyLysThrThr-123 150-LeuGluAlaGluLeuGlnArgGluGlyLysLysAlaAsp-162 174-GluAsnThrGluSerLeuArgPro-181 189-IleSerGluAspHisLeuAspArgTyrAspAspLeuLeu-201 204-AlaHisThrLysAlaGluIlePheArgGlyAspGly-215 228-AlaMetLysArgAlaGlyArgGluValLysArgPheSerLeuGluHisGluAla-245 251-ArgGlyThrGlyCysLeuLysGlnGlyAsnGluAspLeuIleSer-265 291-GlyLeuProArgGluAlaLeu-297 309-HisArgValGluLysIleGlyGluLysAsnGly-319 324-AspAspSerLysGlyThrAsn-330 353-GlyLysGlyGlnAsp-357 359-ThrProLeuArgAspAlaLeuLysAspLysAlaLys-370 380-ProGlnIleArgArgAspLeuAspGly-388 397-ValThrLeuGluGluAlaVal-403 431-TyrAlaHisArgSer-435 g086 AMPHI Regions - AMPHI 55-MetArgThrTrpArgArgLeuValPro-63 83-IleAsnGlyAlaThrArg-88 99-ProThrGluLeuPheLysLeuAlaVal-107 120-GluValLeuArgSerMetGluSerLeuGlyTrpGlnSerIleTrpArgGlyThrAlaAsn-139 155-GluMetTyrGlyArgPhe-160 185-SerPheValValIle-189 228-ArgValGlnArgValValAlaPheLeuAspProTrpLysAspProGln-243 293-GlyPhePheGlyMetCys-298 336-TrpIleGlyIleGlnSerPhe-342 Antigenic Index - Jameson-Wolf 20-LeuAlaSerLysGluGlyGlyAsp-27 54-ArgMetArgThrTrpArgArg-60 79-AlaGlyArgGluIleAsnGlyAla-86 115-PheThrArgArgGluGluValLeuArgSerMetGlu-126 134-TrpArgGlyThrAla-138 144-AlaThrAsnProGlnAlaArgArgGluThrLeuGluMet-156 225-AlaProTyrArgVal-229 236-LeuAspProTrpLysAspProGlnGlyAla-245 265-GlyLeuGlyAlaSerLeuSerLysArgGlyPheLeu-276 313-SerIleGlyLysGlnSerArgAspLeuGly-322 352-LeuProThrLysGlyLeu-357 382-1leAspTyrGluAsnArgGlnLysMetArgGlyTyrArgValGlu-396 Hydrophilic Regions - Hopp-Woods 21-AlaSerLysGluGlyGlyAsp-27 79-AlaGlyArgGluIleAsnGly-85 115-PheThrArgArgGluGluValLeuArgSerMetGlu-126 147-ProGlnAlaArgArgGluThrLeuGluMet-156 238-ProTrpLysAspProGlnGly-244 270-LeuSerLysArgGlyPheLeu-276 316-LysGlnSerArgAspLeu-321 382-IleAspTyrGluAsnArgGlnLysMetArgGlyTyrArgValGlu-396 g087 AMPHI Regions - AMPHI 80-LysThrValArgGluAlaGlnArgIleIle-89 99-GlyPheGlyGlyPheValThrPheProGlyGlyLeuAlaAlaLysLeuLeu-115 129-GlyLeuSerAsnArgHisLeuSerArgTrpAlaLysArgValLeuTyrAlaPheProLys-148 157-ValGlyAsnProValArg-162 192-GlyAlaAspValLeuAsnLysThrVal-200 241-ValGluPheIleThrAspMetValSerAlaTyr-251 313-GluLysLeuAlaGluIleLeuGly-320 330-TrpAlaGluAsnAla-334 Antigenic Index - Jameson-Wolf 25-AspSerLeuArgValArgGly-31 37-LeuGlySerLysAspSerMetGluGluArgIleValProGlnTyrGlyIle-53 61-LysGlyIleArgGlyAsnGlyIleLysArgLysLeu-72 80-LysThrValArgGluAlaGlnArgIleIleArgLysHisArgVal-94 130-LeuSerAsnArgHisLeuSerArgTrpAlaLys-140 150-PheSerHisGluGlyGlyLeu-156 159-AsnProValArgAlaAspIleSer-166 171-ProAlaGluArgPheGlnGlyArgGluGlyArgLeu-182 195-ValLeuAsnLysThrVal-200 207-LeuProGluGluValArgProGlnMetTyrHisGlnSerGlyArgAsnLysLeuGly-225 229-AlaAspTyrAspAla-233 235-GlyValLysAlaGluCys-240 249-SerAlaTyrArgAspAlaAsp-255 284-AlaValAspAspHisGlnThrAla-291 309-GlnLeuThrAlaGluLysLeuAlaGlu-317 321-SerLeuAsnArgGluLysCysLeuLys-329 332-GluAsnAlaArgThr-336 341-HisSerAlaAspAspValAlaGlu-348 Hydrophilic Regions - Hopp-Woods 25-AspSerLeuArgValArgGly-31 39-SerLysAspSerMetGluGluArgIleVal-48 66-AsnGlyIleLysArgLysLeu-72 81-ThrValArgGluAlaGlnArgIleIleArgLysHisArgVal-94 134-HisLeuSerArgTrpAlaLys-140 161-ValArgAlaAspIle-165 171-ProAlaGluArgPheGlnGlyArgGluGlyArgLeu-182 207-LeuProGluGluValArgPro-213 219-SerGlyArgAsnLysLeu-224 235-GlyValLysAlaGluCys-240 249-SerAlaTyrArgAspAlaAsp-255 284-AlaValAspAspHisGlnThrAla-291 310-LeuThrAlaGluLysLeuAlaGlu-317 322-LeuAsnArgGluLysCysLeuLys-329 341-HisSerAlaAspAspValAlaGlu-348 g088-2 AMPHI Regions - AMPHI 7-HisPheSerAsnTrpLeuThrGlyLeuAsnIlePheGlnTyrThrThr-22 24-ArgAlaValMetAlaAlaLeu-30 43-ThrIleArgArgLeuThrAlaLeuLysCysGlyGln-54 88-LeuTrpGlyAεnTrpAlaAsn-94 Hl-GlyPheTyrAspAspTrpArgLysValValTyr-121 140-AlaValIleAlaGlyLeuAlaLeu-147 175-GlyPheLeuValLeuSerTyrLeuThrIle-184 187-ThrSerAsnAlaValAsnLeuThrAspGlyLeuAspGlyLeuAlaAla-202 221-HisTyrGlnPheSerGlnTyrLeuGlnLeuProTyr-232 244-ThrAlaMetCysGlyAlaCysLeuGlyPhe-253 Antigenic Index - Jameson-Wolf 48-ThrAlaLeuLysCysGlyGlnAlaValArgThrAspGlyProGln-62 66-ValLysAsnGlyThrProThrMet-73 114-AspAspTrpArgLysValValTyrLysAspProAsnGlyValSerAlaLysPhe-131 193-LeuThrAspGlyLeuAsp-198 312-LysLysThrLysLysArgIle-318 328-TyrGluGlnLysGlyTrpLysGluThrGlnVal-338 Hydrophilic Regions - Hopp-Woods 56-ValArgThrAspGlyProGln-62 114-AspAspTrpArgLysValValTyrLysAspProAsnGlyVal-127 312-LysLysThrLysLysArgIle-318 331-LysGlyTrpLysGlu-335 g089 AMPHI Regions - AMPHI 40-PheSerThrArgCysGlyLysProTrpLysValLeu-51 74-LeuAlaAlaLeuCysLysProCysSerGlyMetSerCys-86 119-ArgProAlaArgPhe-123 Antigenic Index - Jameson-Wolf 1-MetProProLysIleThrLysSerGlyPhe-lO 40-PheSerThrArgCysGlyLysProTrpLys-49 53-CysSerSerAsnAlaSerArgGlyLysProThrAlaSerHisLysAla-68 77-LeuCysLysProCysSerGlyMetSer-85 87-ValGluIleLysSerSerLeuProCysPheLysGlnProValProArgSerAsnGlnLysSerAlaSerCysS erLysGluAsnArgPheThrSerArgPrOAlaArgPheMetAlaArgGlnAsnThrSerSerAlaPheLysThrCy sThrProSerProArgLysIleSer-144 Hydrophilic Regions - Hopp-Woods 43 -ArgCysGlyLysPro-47 56-AsnAlaSerArgGlyLysProThrAlaSerHisLysAla-68 87-ValGluIleLysSer-91 99-ProValProArgSerAsnGlnLysSerAlaSerCysSerLysGluAsnArgPheThrSerArgProAlaArgP heMetAla-125 137-ThrProSerProArgLysIleSer-144 g090-l AMPHI Regions - AMPHI 10-SerGlnSerLeuLysArgPheAspLysHisPheArg-21 51-ArgLeuAsnArgLeuPhe-56 59-AspAlaValGlyGlnVal-64 129-PheAlaValValAspGlu-134 141-AlaAspPhePheHisThrValArgGlnAla-150 152-GluGlyPheAspValPheGlnGlnCysPheAla-162 164-GlnThrAspGlyLeuAlaGln-170 177-ValGlyGlyValValGlnThrLeuGlnArg-186 233-ValValArgIleGlnAsnLeuHisSerIle-242 253-ValValGluGlnIle-257 388-GluThrValValGlnArgIlePheGlnThrThr-398 404-ProValLysHisLeuThrAspLeuArg-412 425-AsnLeuArgAlaValPheAlaGlnIleGlyAsnHisGlyAsnThrArgAlaAlaLysSer-444 Antigenic Index - Jameson-Wolf 8-ThrAlaSerGlnSerLeuLysArgPheAspLysHisPheArg-21 29-HisIleGluThrArgAlaGlyGlyAlaGluGlnAspAsnIleAla-43 51-ArgLeuAsnArgLeuPheGlnSerAspAlaVal-61 73-AlaAspLeuArgArgIleAspAlaAspGlnGluHis-84 94-AlaGlnGlyArgGluVal-99 107-GlnAsnHisGluGluArgValLeuGlnThrGlyAsnArgGlyGlyGlyArgAlaAspIleArg-127 149-GlnAlaLeuGluGlyPhe-154 161-PheAlaArgGlnThrAspGlyLeuAlaGlnSerHisGlySerHisAsnValGlyGly-179 183-ThrLeuGlnArgAspValLeuArgArgAsnGln-193 201-ThrAlaArgProAlaPheGlnPro-208 214-PheGlnGlyLysProPheHisPheThrProCysPro-225 268-ValHisHisArgArgArgSerArgAlaGln-277 285-GluAlaGlyLysLeuGln-290 305-LeuGlnAsnArgArgThrAspIleAlaArgAsnAspGlylleGlnPro-320 322-LeuAspAlaGluIleAlaAspGlnAlaArgTyrArgGly-334 339-AlaGlyAsnArgAsnHis-344 353-ValArgGlnGlnPhe-357 369-GluArgLeuAspIle-373 379-AspAlaGlyThrGluArgGlnAsnIle-387 396-GlnThrThrArgValLysHisGlnProVal-405 407-HisLeuThrAspLeuArgHis-413 422-IleSerGlyAsnLeu-426 435-AsnHisGlyAsnThrArgAlaAlaLysSerGlyAspGluAspPhePhe-450 Hydrophilic Regions - Hopp-Woods 9-AlaSerGlnSerLeuLysArgPheAspLysHisPheArg-21 29-HisIleGluThrArgAlaGlyGlyAlaGluGlnAspAsnIleAla-43 73-AlaAspLeuArgArgIleAspAlaAspGlnGluHis-84 94-AlaGlnGlyArgGluVal-99 107-GlnAsnHisGluGluArgValLeu-114 117-GlyAsnArgGlyGlyGlyArgAlaAspIleArg-127 163-ArgGlnThrAspGlyLeuAla-169 184-LeuGlnArgAspValLeuArgArgAsnGln-193 269-HisHisArgArgArgSerArgAla-276 285-GluAlaGlyLysLeuGln-290 306-GlnAsnArgArgThrAsplleAlaArgAsnAspGlyl1e-318 322-LeuAspAlaGluIleAlaAspGlnAlaArgTyrArg-333 369-GluArgLeuAspIle-373 380-AlaGlyThrGluArgGlnAsnIle-387 398-ThrArgValLysHisGlnPro-404 409-ThrAspLeuArgHis-413 437-GlyAsnThrArgAlaAlaLysSerGlyAspGluAspPhePhe-450 g091 AMPHI Regions - AMPHI 38-LysProLeuΞerAspGlyIleAlaSerArgLeuIleThrArgLeu-52 61-ValLeuValSerValLeuThrSerLeuAlaLys-71 Antigenic Index - Jameson-Wolf 5-ValProProSerProAlaThr-ll 28-IleLeuGlyArgArgArgProProLeuProLysProLeuSerAspGlyIleAla-45 73-LeuLeuSerGluArgLysValLeu-80 Hydrophilic Regions - Hopp-Woods 28-IleLeuGlyArgArgArgProProLeu-36 73-LeuLeuSerGluArgLysValLeu-80 g092 AMPHI Regions - AMPHI 55-GlyMetSerGlyIleAlaGluValLeuHis-64 76-AlaArgAsnAlaAlaThrGluHisLeu-84 95-HisThrAlaGluHisValAsnGly-102 122-AlaLeuGluArgGln-126 137-AlaGluLeuMetArgPheArgAsp-144 209-LeuThrProIleMetSerValValThrAsnIleAsp-220 226-ThrTyrGlyHisSerValGluLysLeuHisGlnAlaPheIleAspPheIleHisArg-244 260-ValArgAlaIleLeuProLysValΞerLysProTyr-271 273-ThrTyrGlyLeuAspAspThrAla-280 321-AsnValLeuAsnAlaLeuAlaAlaIle-329 339-ValGluAlaIleGlnLysGly-345 353-GlyArgArgPheGlnLysTyrGlyAspIleLys-363 407-ArgTyrThrArgThrArgAspLeuPheGluAspPheThrLysValLeuAsnThrValAspAlaLeu-42! 449-LeuAlaArgAlaIleArgValLeuGlyLysLeu-459 464-CysGluAsnValAlaAspLeuProGlnMetLeuMetAsn-476 Antigenic Index - Jameson-Wolf 17-AlaAsnGlyGlnThrPhe-22 25-ThrProLeuArgThrLysAsnGlnProGluArgAsnIleMetMetLysAsnArgVal-43 70-ValSerGlySerAspGlnAlaArgAsnAlaAla-80 lll-AlaValLysLysGluAsnProGluVal-119 121-AlaAlaLeuGluArgGlnIle-127 140-MetArgPheArgAspGlyIle-146 150-GlyThrHisGlyLysThrThrThr-157 184-GlyThrAsnAlaArgLeuGlyLysGlyGluTyr-194 198-GluAlaAspGluSerAspAla-204 218-AsnIleAspGluAspHisMetAspThrTyrGly-228 230-SerValGluLysLeuHis-235 255-ValAspSerGluHisVal-260 263-IleLeuProLysValSerLysProTyrAla-272 275-GlyLeuAspAspThrAlaAsp-281 286-AspIleGluAsnValGlyAla-292 302-MetLysGlyHisGluGlnGlySerPhe-310 351-GlyValGlyArgArgPheGlnLysTyrGlyAspIleLysLeuProAsnGlyGly-368 374-AspAspTyrGlyHisHisPro-380 393-AlaTyrProGluLysArgLeu-399 404-GlnProHisArgTyrThrArgThrArgAspLeuPheGluAspPheThrLys-420 435-AlaAlaGlyGluGluProValAlaAlaAlaAspSerArgAlaLeuAlaArg-451 478-LeuGlnAspGlyAspVal-483 488-GlyAlaGlySerIleAsnArgValProSerAla-498 Hydrophilic Regions - Hopp-Woods 26-ProLeuArgThrLysAsnGlnProGluArgAsnIleMetMetLysAsnArgVal-43 71-SerGlySerAspGlnAlaArgAsnAlaAla-80 Hl-AlaValLysLysGluAsnProGlu-118 121-AlaAlaLeuGluArgGlnIle-127 140-MetArgPheArgAsp-144 152-HisGlyLysThrThr-156 187-AlaArgLeuGlyLysGlyGlu-193 198-GluAlaAspGluSerAspAla-204 218-AsnIleAspGluAspHisMetAsp-225 230-SerValGluLysLeuHis-235 256-AspSerGluHisVal-260 275-GlyLeuAspAspThrAlaAsp-281 303-LysGlyHisGluGlnGlySer-309 351-GlyValGlyArgArgPheGlnLys-358 360-GlyAspIleLysLeu-364 393-AlaTyrProGluLysArgLeu-399 407-ArgTyrThrArgThrArgAspLeuPheGluAspPheThrLys-420 435-AlaAlaGlyGluGluProValAlaAlaAlaAspSerArgAlaLeuAlaArg-451 479-GlnAspGlyAspVal-483 g093-2 AMPHI Regions - AMPHI 26-ThrAlaIleLeuAsn-30 59-ThrAlaPheAsnIleLeuHisGly-66 156-GlyArgLeuLysSerValTyrGluGluLeuLysHisLeu-168 196-IleHisIleIleProAlaThrGluPhe-204 254-PheLeuLysAspThr-258 267-IleAsnThrLeuProGlyMetThrGly-275 Antigenic Index - Jameson-Wolf 12-GlyGlyPheSerSerGluArgGluIleSerLeuAspSerGlyThr-26 32-LeuLysSerLysGlyIleAsp-38 41-AlaPheAspProLysGluThrProLeuSerGluLeuLysGluArgGlyPhe-57 66-GlyThrTyrGlyGluAspGlyAlaVal-74 96-GlyMetAspLysTyrArgCys-102 121-AspAspThrAspPheAspAlaValGluGluLysLeuGly-133 140-ProAlaAlaGluGlySerSer-146 151-LysValLysGluLysGlyArgLeuLysSerValTyrGluGluLeuLysHisLeuGln-169 176-ArgPheIleGlyGlyGlyGluTyrSer-184 189-AsnGlyLysGlyLeuPro-194 203-GluPheTyrAspTyrGluAlaLysTyrAsnArgAspAspThrIleTyrGlnCysProSerGluAspLeuThr GluAlaGluGluSerLeuMetArg-234 245-GlyAlaGluGlyCysVal-250 253 -AspPheLeuLysAspThrAspGly-260 269-ThrLeuProGlyMetThr-274 279-ValProLysSerAlaAla-284 Hydrophilic Regions - Hopp-Woods 15-SerSerGluArgGluIleSerLeu-22 32-LeuLysSerLysGlyIleAsp-38 41-AlaPheAspProLysGluThrProLeuSerGluLeuLysGluArgGlyPhe-57 68-TyrGlyGluAspGlyAlaVal-74 96-GlyMetAspLysTyrArgCys-102 121-AspAspThrAspPheAspAlaValGluGluLysLeuGly-133 140-ProAlaAlaGluGlySerSer-146 151-LysValLysGluLysGlyArgLeuLysSerValTyrGluGluLeuLysHisLeuGln-169 205-TyrAspTyrGluAlaLysTyrAsnArgAspAspThrIle-217 221-ProSerGluAspLeuThrGluAlaGluGluSerLeuMetArg-234 253-AspPheLeuLysAspThrAspGly-260 g094 AMPHI Regions - AMPHI 17-LeuProProIleThrLysValGlySer-25 64-ArgGlyIleThrGlyIleCysArg-71 80-PheSerPheLeuThrAlaVal-86 Antigenic Index - Jameson-Wolf 4-ProLeuProLysArgAlaLeu-10 24-GlySerSerProAlaAlaProArgMetGluAla-34 50-MetProSerArgLysArgIleSer-57 60-SerIleLysAlaArgGly-65 70-CysArgSerAsnAlaAlaThrThrSer-78 Hydrophilic Regions - Hopp-Woods 5-LeuProLysArgAlaLeu-10 28-AlaAlaProArgMetGluAla-34 51-ProSerArgLysArgIleSer-57 60-SerIleLysAlaArgGly-65 g095-2 AMPHI Regions - AMPHI 7-GlyGlyCysIleSerAsnLeuPheArgGlnPheGlnGlnArgGlyGlyAsnAlaValAsp-26 38-IleLeuXxxAsnIleHisGlnHisLeuArgGlnValGlyAspValPheAlaVal-55 63-TyrAlaAspSerThr-67 86-PheGlyGlnTyrGlnArgIleAsnGlyIleGluTyrPheGlyLysValPheLysGlnIleAlaArg-107 131-LysGlyCysArgHisPheAspGlyValValSer-141 174-PheLeuAspArgPheAsnArgCysAlaAspPheGlnArgHisAlaAspGlyCysGlnCysValGlnHisVal -197 204-GlnHisAspPheLys-208 236-AspValGlyGlyIleValGlnThrValSerSerIle-247 274-ThrValAspGluIleAspLysArgLeuMetGlnPhePheAspAlaVal-289 370-AsnGlyAspAlaValThrGluAlaHis-378 417-ValAsnValPheCysGly-422 435-MetLeuGlySerGlyIleSerArgLeuIleArgThrGly-447 451-AlaGlnIleValGlnAspPheGlyAspThrAlaHisAla-463 Antigenic Index - Jameson-Wolf 17-PheGlnGlnArgGlyGlyAsnAlaValAspAlaSerArgThrHisIle-32 62-GlnTyrAlaAspSerThrArgGlnGlyAlaGlyValGlyGlyGlyAsnArg-78 112-ValArgLeuGluGlyGluHisGlnThr-120 126-AlaAlaCysSerGlyLysGlyCysArgHisPheAspGly-138 163-AlaAlaAlaAspAlaPheLysAlaGluGlnAlaPhe-174 176-AspArgPheAsnArgCysAlaAspPheGlnArgHisAlaAspGlyCysGln-192 205-HisAspPheLysArg-209 253-GlyGlnAsnArgAlaAspVal-259 263-AsnThrGlnLysGlyPheAlaVal-270 273-HisThrValAspGluIleAspLysArgLeu-282 299-AspIleGlyAsnAspGlyHisAsnArgGlyGlnMetXxxGluArgGlyIle-315 339-PheAlaAlaAspAsnGluSerGlyValGluSerCysArgAlaGluAspGlyGlyGlyGlnAlaGlyGlyArg -362 364-PheAlaValArgThrGlyAsnGlyAspAlaValThr-375 384-GlnGlyAlaArgAsnAsnGlyAsnLeuProLeuGlnArgSerAspAsnPheGly-401 405-LeuAspGlyGlyArgGlyAsnAspAspIleArgThr-416 442-ArgLeuIleArgThrGlyAsnPheLys-450 455-GlnAspPheGlyAspThrAlaHisAlaAspAlaAlaAspThrAspLysMetAspVal-473 Hydrophilic Regions - Hopp-Woods 17-PheGlnGlnArgGlyGlyAsnAlaValAspAlaSerArgThrHisIle-32 65-AspSerThrArgGlnGlyAla-71 112-ValArgLeuGluGlyGluHis-118 128-CysSerGlyLysGlyCysArgHisPheAsp-137 163-AlaAlaAlaAspAlaPheLysAlaGluGlnAlaPhe-174 182-AlaAspPheGlnArgHisAlaAspGly-190 205-HisAspPheLysArg-209 273-HisThrValAspGluIleAspLysArgLeu-282 300-IleGlyAsnAspGlyHisAsnArgGlyGlnMetXxxGluArgGlyIle-315 339-PheAlaAlaAspAsnGluSerGlyValGluSerCysArgAlaGluAspGlyGlyGly-357 368-ThrGlyAsnGlyAspAlaValThr-375 384-GlnGlyAlaArgAsnAsnGly-390 394-LeuGlnArgSerAspAsn-399 407-GlyGlyArgGlyAsnAspAspIleArgThr-416 461-AlaHisAlaAspAlaAlaAspThrAspLysMetAspVal-473 g096-2 AMPHI Regions - AMPHI 19-GlyIlePheGluGluIleAspAlaHis-27 59-IleAsnGlyValValSerVal-65 112-GlnPhePheValAsnAlaPheGlnThrAlaPhePhePheAsp-125 161-GluLeuGlyAsnGlyXxx-166 172-AsnGlnPheAlaAla-176 188-ThrAlaAlaGlyIleGlyAsnAlaGln-196 228-XxxArgArgPheLeu-232 Antigenic Index - Jameson-Wolf 4-HisThrGlyGlnGly-8 22-GluGluIleAspAla-26 30-PheArgThrAspCys-34 74-LeuGlyCysGlyAspAspValTyrAla-82 88-ValGlnAspGlyAla-92 97-AlaAlaAspLysThrPheGlyAsn-104 133-AlaPheGlyArgArgLeuHisLysHisArgGlnThr-144 161-GluLeuGlyAsnGlyXxxSerGlnCysLeu-170 181-AlaAspGlyGlyGlyGlyAspThr-188 211-ThrValLysAspValGluCysArgLeuLysAla-221 Hydrophilic Regions - Hopp-Woods 22-GluGluIleAspAla-26 75-GlyCysGlyAspAspValTyr-81 97-AlaAlaAspLysThrPheGly-103 133-AlaPheGlyArgArgLeuHisLysHisArgGln-143 182-AspGlyGlyGlyGlyAspThr-188 211-ThrValLysAspValGluCysArgLeuLysAla-221 g097 AMPHI Regions - AMPHI 28-AlaGlyLeuThrThrPheLeuThrMetCysTyrIleVal-40 166-AlaThrLeuValGlyLeuGlyAspIleHisGlnProSerAlaLeuLeuAlaLeuPheGlyPheValMetVal ValValLeu-192 207-ThrIleThrValIleAlaSerLeuMetGlyLeuAsnGluPheHisGlyValValGlyGluValProGlyIle -230 242-LeuPheThrValSer-246 260-PheAspSerThrGlyThr-265 362-MetLeuArgSerAlaArgAspIle-369 Antigenic Index - Jameson-Wolf l-MetAspIleSerLysGlThrLeuLeu-9 16-LysAlaAsnGlyThrThrValArgThrGluLeu-26 125-LysValArgGluMetLeu-130 260-PheAspSerThrGly-264 277-ValAspGlyLysLeuProArgLeuLysArg-286 317-SerAlaGlyGlyArgThrGly-323 364-ArgSerAlaArgAspIleAspTrpAspAspMetThrGlu-376 410-LeuCysArgArgThrGlyAspValPro-418 Hydrophilic Regions - Hopp-Woods l-MetAspIleSerLys-5 17-AlaAsnGlyThrThrValArgThrGluLeu-26 125-LysValArgGluMetLeu-130 279-GlyLysLeuProArgLeuLysArg-286 318-AlaGlyGlyArgThr-322 364-ArgSerAlaArgAspIleAspTrpAspAspMetThrGlu-376 410-LeuCysArgArgThrGlyAsp-416 g098 AMPHI Regions - AMPHI 33-AspGlnPheValGlyAspValAlaArg-41 62-ThrHisHisValHisArgMetGly-69 Antigenic Index - Jameson-Wolf 25-GlnGlnAspAlaAlaGlnAlaGlyAspGlnPheVal-36 53-AsnAlaAlaGluHisGlyHisAlaGly-61 67-ArgMetGlyMetCysArg-72 79-AsnHisThrAspArgGlnAla-85 Hydrophilic Regions - Hopp-Woods 26-GlnAspAlaAlaGlnAla-31 54-AlaAlaGluHisGlyHis-59 79-AsnHisThrAspArgGlnAla-85 g099 AMPHI Regions - AMPHI 6-SerMetMetArgLeuProAspIleVal-14 47-AlaPheValGluPhePheGlyGluGly-55 102-LysLeuValGluThrTyrAlaLysThr-llO 114-TrpAlaGlyGlyLeuLys-119 135-ThrArgAsnMetAlaGlyProSerAsn-143 154-AlaAlaLysGlyLeuAlaLysProTyrGluGluProSerAspGlyGln-169 178-AlaAlaIleThrSerCysThrAsnThrSerAsnProArgAsnVal-192 251-ThrCysAsnGlyMetΞer-256 341-IleAspAlaIleValAlaGluTyr-348 350-LysProGlnGlnPheArgAspIle-357 371-ProSerProLeuTyrAspTrpArg-378 381-SerThrTyrIleArg-385 398-ArgThrLeuArgGlyMetArgProPro-406 443-AspPheAsnSerTyrAlaThr-449 468-PheAsnGluMetValArg-473 494-MetArgMetTrpGluAlaIleGluThrTyrMet-504 532-ArgLeuAlaGlyValGluAlaIle-539 541-AlaGluGlyPheGluArgIleHisArgThrAsn-551 575-GlyThrGluThrTyr-579 Antigenic Index - Jameson-Wolf 18-LeuThrGlyLysArgGlnAla-24 38-PheLeuArgLysGluArgValVal-45 53-GlyGluGlyAlaArgSer-58 60-SerIleGlyAspArgAlaThr-66 70-MetThrProGluPhe-74 94-ThrGlyArgAspAspAlaGlnValLysLeu-103 133-SerValThrArgAsnMetAlaGlyProSerAsnProHis-145 157-GlyLeuAlaLysProTyrGluGluProSerAspGlyGlnMetProAspGly-173 183-CysThrAsnThrSerAsnProArgAsnVal-192 201-AsnAlaAsnArgLeuGlyLeuLysArgLysProTrpVal-213 216-SerPheAlaProGlySerLysValAla-224 235-ProGluMetGluLysLeu-240 251-ThrCysAsnGlyMetSerGlyAlaLeuAspProLysIleGlnGlnGluIleIleAspArgAspLeuTyr-27 3 279-SerGlyAsnArgAsnPheAspGlyArgIleHisProTyrAlaLys-293 312-IleArgPheAspIleGluAsnAspVal-320 322-GlyValAlaAspGlyArgGluIleArgLeuLysAspIleTrpProThrAspGluGluIleAsp-342 348-TyrValLysProGlnGlnPheArgAsp-356 361-MetSerAspThrGlyThrAlaGlnLysAlaProSerProLeuTyrAspTrpArgProMetSerThrTyrIle ArgArgProProTyrTrp-390 394-LeuAlaGlyGluArgThrLeuArgGlyMetArgProProAlaIleLeuProAspAsnIleThrThrAspHis IleSerProSerAsn-422 438-GlyLeuProGluGluAspPheAsnSerTyrAlaThrHisArgGlyAspHisLeuThr-456 463-AlaAsnProLysLeuPhe-468 471-MetValArgAsnGluAspGlySerValArgGlnGlySerLeuAlaArgValGluProGluGlyGlnThr-49 3 503-TyrMetAsnArgLysGlnPro-509 516-AlaAspTyrGlyGlnGlySerSerArgAspTrpAlaAlaLysGlyValArg-532 542-GluGlyPheGluArgIleHisArgThrAsnLeu-552 562-PheLysProGlyThrAsnArgHisThrLeuGlnLeuAspGlyThrGluThrTyrAspValValGlyGluArg ThrProArgCysGly-590 595-IleHisArgLysAsnGlyGluThrValGlu-604 607-ValThrCysArgProAspThrAlaGluGlu-616 Hydrophilic Regions - Hopp-Woods 18-LeuThrGlyLysArgGlnAla-24 38-PheLeuArgLysGluArgValVal-45 53-GlyGluGlyAlaArg-57 60-SerIleGlyAspArgAlaThr-66 94-ThrGlyArgAspAspAlaGlnValLysLeu-103 157-GlyLeuAlaLysProTyrGluGluProSerAspGlyGlnMetPro-171 205-LeuGlyLeuLysArgLysProTrpVal-213 235-ProGluMetGluLysLeu-240 259-LeuAspProLysIleGlnGlnGluIleIleAspArgAspLeuTyr-273 282-ArgAsnPheAspGlyArglle-288 312-IleArgPheAspIleGluAsnAspVal-320 324-AlaAspGlyArgGluIleArgLeuLysAsp-333 335-TrpProThrAspGluGluIleAsp-342 363-AspThrGlyThrAlaGlnLysAlaPro-371 394-LeuAlaGlyGluArgThrLeuArgGlyMetArg-404 438-GlyLeuProGluGluAspPheAsn-445 450-HisArgGlyAspHis-454 471-MetValArgAsnGluAspGlySerValArgGln-481 485-AlaArgValGluProGluGlyGlnThr-493 503-TyrMetAsnArgLysGlnPro-509 518-TyrGlyGlnGlySerSerArgAspTrpAlaAlaLysGlyValArg-532 542-GluGlyPheGluArgIleHisArg-549 564-ProGlyThrAsnArgHis-569 574-AspGlyThrGluThr-578 580-AspValValGlyGluArgThrProArg-588 596-HisArgLysAsnGlyGluThrValGlu-604 609-CysArgProAspThrAlaGluGlu-616 gl02 AMPHI Regions - AMPHI 26-ProAsnProThrAlaAsnLeuGlyAspGlyLeu-36 70-PheAspThrMetValLysAspLeuLeuGlyArgGlyTrpAsnIleIleAsnGlyIleAla-89 109-ThrAlaLysGlyIleGlySerAlaVal-117 128-LeuValPhePheGlyIleLeuAlaPheCys-137 144-LeuValAspArgPheThrGlyValLeu-152 155-GlyMetValLeuThr-159 207-AsnValSerSerLeuLeuLysTyrPheLys-216 221-LysValAlaLysSerIle-226 266-LeuAsnGluThrLeuSerLysPheAlaGlnThrGlyAspMetAspLysIleLeuSerLeuPheProTyr-2. 8 300-LeuGlyLeuPheAspAsnIleAlaAspIlePheLysTrpAsnAsp-314 316-MetSerGlyArgGly-320 342-PhePheThrAlaIleGlyAla-348 374-GlyAlaGlyLysThrTyrLysVal-381 Antigenic Index - Jameson-Wolf l-MetSerAlaLysThrProSerLeu-8 26-ProAsnProThrAlaAsnLeuGlyAspGlyLeu-36 62-ThrHisAsnProArgGlyAlaSer-69 77-LeuLeuGlyArgGly-81 106-GlyAspLeuThrAla-110 169-AlaAspAlaLysPro-173 179-ThrGlnAlaProValGlyThr-185 214-TyrPheLysGlyAspAlaProLysValAla-223 246-SerAsnLeuProArgAsnGluPhe-253 258-AlaAlaGluArgGlnLeu-263 274-AlaGlnThrGlyAspMetAspLys-281 311-LysTrpAsnAspSerMetSerGlyArgGlyThrLys-322 369-SerProGlnLysIleGlyAlaGlyLysThrTyr-379 Hydrophilic Regions - Hopp-Woods l-MetSerAlaLysThr-5 62-ThrHisAsnProArgGlyAlaSer-69 169-AlaAspAlaLysPro-173 215-PheLysGlyAspAlaProLysValAla-223 247-AsnLeuProArgAsnGluPhe-253 258-AlaAlaGluArgGlnLeu-263 277-GlyAspMetAspLys-281 316-MetSerGlyArgGlyThrLys-322 371-GlnLysIleGlyAla-375 gl05 AMPHI Regions - AMPHI H-TrpValGlyLeuGly-15 22-ValThrArgLeuLeuAsp-27 51-LysValTyrGlySerThrAlaGluLeuValArgAlaCys-63 74-AlaAlaValCysAspIleLeuAsnGlyValArgAspGlyLeu-87 97-ThrIleSerProThr-101 110-ValGluAlaAlaGlyGlyGlnPheAlaGluAlaProVal-122 143-AlaValLeuAsnProLeuGlnLysIlePheSer-153 162-PheGlyAspValGlyLysGlySer-169 176-AsnSerLeuLeuGlyIlePheGlyGluAlaTyr-186 203-IleValGluAlaIleGlyGlySerAla-211 249-LeuGluGlnAlaGlyAsnThrLeuProAlaValGlu-260 263-AlaAlaSerTyrArgLysAlaValGluAla-272 Antigenic Index - Jameson-Wolf 25-LeuLeuAspGlyGlyIleGlu-31 34-ValTyrAsnArgSerProAspLysThrAlaProIleSerAlaLysGlyAlaLysValTyrGlySer-55 81-AsnGlyValArgAspGlyLeuAla-88 96-SerThrIleSerProThrGluAsnLeuAla-105 121-ProValSerGlySerValGlyProAlaThr-130 139-GlyGlySerGluAla-143 155-ValGlyLysLysThrPheHisPheGlyAspValGlyLysGlySerGly-170 196-PheGlyIleAspThrAspThrIleVal-204 210-SerAlaMetAspSerProMetPheGlnThrLysLysSerLeuTrpAlaAsnArgGluPheProPro-231 237-HisAlaSerLysAspLeuAsnLeuAlaValLysGluLeuGluGlnAlaGlyAsnThrLeuPro-257 264-AlaSerTyrArgLysAlaValGluAlaGlyTyrGlyGluGlnAspValSerGly-281 Hydrophilic Regions - Hopp-Woods 25-LeuLeuAspGlyGlyIle-30 37-ArgSerProAspLysThrAlaProIleSerAlaLysGlyAlaLys-51 81-AsnGlyValArgAspGlyLeuAla-88 164-AspValGlyLysGlySerGly-170 196-PheGlyIleAspThrAspThrIle-203 218-GlnThrLysLysSerLeuTrpAla-225 237-HisAlaSerLysAspLeuAsnLeuAlaValLysGluLeuGluGlnAlaGly-253 265-SerTyrArgLysAlaValGlu-271 273-GlyTyrGlyGluGlnAspVal-279 gl09-2 AMPHI Regions - AMPHI 6-GlyThrTyrArgAspLeuHisArgProAlaSerGlu-17 53-LeuIleProAlaMetAlaGlyThrIleGly-62 143-GlyLeuLeuMetAla-147 154-IleMetAlaLysLeuThrSer-160 175-GlyThrThrGlyGlnValLysLysLeuPheSerTrpAlaGly-188 205-ValMetTyrAlaLeuLeuGluHisTrpLysLysArgTrpLeu-218 220-ValProLeuGlyCys-224 292-HisGlnValPheGlnLysIle-298 324-ValGlySerIleLeuGly-329 334-ThrSerSerTrpGlyThr-339 465-AlaValGlyMetLeuProGlyIleProProPheLeuGluGlnPheLysSerLeu-482 Antigenic Index - Jameson-Wolf l-MetGluLysHisAsnGlyThrTyrArgAspLeuHisArgProAlaSer-16 18-PheAlaThrArgAspGluTyrLeuGlu-26 32-MetGlnProLysArgTrpArgProAsnLeuProPheArgAspTyrArgPheGluTrp-50 76-LeuGlyLeuProAsp-80 107-ProGlyAlaAsnLeuProGlyThrHis-115 158-LeuThrSerAsnGlyVal-163 177-ThrGlyGlnValLysLys-182 243-AlaProGlyLeuProPro-248 254-TrpXxxGlyGluAsnSerGlyTrpHis-262 299-SerTyrProGluLysThrAspLysVal-307 310-AsnIleAspAspThrMetThr-316 350-ProIleProGlyGly-354 392-AlaGlyMetGluMetThrArgLysGlyLysThrThrGln-404 435-GlyCysLysGluArgSerAla-441 Hydrophilic Regions - Hopp-Woods l-MetGluLysHisAsnGlyThrTyrArgAspLeuHisArgProAlaSer-16 18-PheAlaThrArgAspGluTyrLeuGlu-26 35-LysArgTrpArgPro-39 44-ArgAspTyrArgPheGluTrp-50 178-GlyGlnValLysLys-182 299-SerTyrProGluLysThrAspLysVal-307 311-IleAspAspThrMetThr-316 392-AlaGlyMetGluMetThrArgLysGlyLysThrThrGln-404 435-GlyCysLysGluArgSerAla-441 glll-2 AMPHI Regions - AMPHI 6-ArgLeuProAsnLeuIleArgAlaLeu-14 58-ProSerProAlaLysIleGlnLysArgIleAspAspAlaLeuLysGluValAsnArgGlnMetSer-79 90-PheAsnGlnHisThrAlaGly-96 128-GlyProLeuValAsnLeuTrp-134 151-IleLysGlnAlaAlaSerTyrThrGly-159 170-AspTyrAlaSerLeu-174 183-LeuAspLeuSerSerIleAlaLys-190 209-TyrLeuValGluIleGlyGly-215 314-GluThrGluAlaLeu-318 320-LeuAlaGluGlnGlu-324 Antigenic Index - Jameson-Wolf 1-MetProSerGluThrArgLeuProAsnLeu-lO 26-CysSerGluGlnThrAla-31 37-GlnGlyGluThrMetGly-42 49-TyrLeuSerAsnAsnArgAspLysLeuProΞerProAlaLysIleGlnLysArgIleAspAspAlaLeuLysG luValAsnArgGlnMetSer-79 81-TyrGlnThrAspSerGluIleSerArgPheAsnGlnHisThrAlaGlyLysProLeuArgIleSerSerAspP he-105 lll-GluAlaValArgLeuAsnArg-117 135-GlyPheGlyProAspLysSerValThrArgGluProSerProGluGlnIleLysGln-153 164-IleLeuGlnGlnGlyLysAspTyrAlaSerLeuSerLysThrHisProLysAla-181 192-PheGlyValAspLysValAlaGlyGluLeuGluLysTyrGly-205 213-IleGlyGlyGluLeuHisGlyLysGlyLysAsnAlaHisGlyGluProTrpArgIleGlyIleGluGlnPro Asn-237 250-LeuAsnAsnArgSerLeuAlaThrSerGlyAspTyrArg-262 264-PheHisValAspLysAsnGlyLysArgLeuSer-274 277-IleAsnProAsnAsnLysArgProIleSer-286 295-ValSerAspSerAlaMetThrAlaAspGlyLeuSer-306 314-GluThrGluAlaLeuArgLeuAlaGluGlnGluLys-325 332-ValArgAspLysAspGlyTyrArg-339 342-MetSerSerGluPhe-346 Hydrophilic Regions - Hopp-Woods l-MetProSerGluThrArgLeu-7 26-CysSerGluGlnThrAla-31 51-SerAsnAsnArgAspLysLeuProSer-59 61-AlaLysIleGlnLysArgIleAspAspAlaLeuLysGluValAsnArgGln-77 82-GlnThrAspSerGluIleSerArg-89 97-LysProLeuArgIleSerSer-103 lll-GluAlaValArgLeuAsnArg-117 137-GlyProAspLysSerValThrArgGluProSerProGluGlnIleLysGln-153 167-GlnGlyLysAspTyrAlaSer-173 175-SerLysThrHisPro-179 192-PheGlyValAspLysValAlaGlyGluLeuGluLysTyrGly-205 217-LeuHisGlyLysGlyLysAsnAlaHis-225 267-AspLysAsnGlyLysArgLeuSer-274 279-ProAsnAsnLysArgProIle-285 314-GluThrGluAlaLeuArgLeuAlaGluGlnGluLys-325 332-ValArgAspLysAspGlyTyrArg-339 gll7-l AMPHI Regions - AMPHI 6-ProIleGlnAspThrGlnSerAla-13 15-LeuGlnGluLeuArgGluTrpPheAspSerTyrCysAla-27 57-GlyGluProLeuProAspHis-63 69-GlnMetValAspGluLeuAspLeuLeu-77 79-AspAlaValAlaAlaThrLeuLeuAlaAspIleGlyArgTyr-92 104-CysAsnSerThrValAlaGluLeuValLysGlyValAspGluValGlnLysLeuThrHisPheAlaArgVal AspSerLeu-130 145-LysMetLeuLeuAlaMet-150 170-PheLeuSerAsnAlaProAspSerProGluLys-180 216-GluProGluLysTyrArg-221 234-ArgLeuGluTyrIleGluAsnPheLeuAspIleLeuArg-246 260-GlyArgProLysHisIleTyrSerIleTyrLys-270 282-LeuPheAspIleArg-286 290-IleLeuValAspThrValProGluCysTyrThrThrLeuGlyIleValHisSerLeuTrpGlnProIlePro GlyGluPheAspAspTyrIleAla-321 327-GlyTyrLysSerLeuHisThr-333 351-AspMetHisGlnPheAsnGluPheGlyValAla-361 385-GlnLeuLeuAspTrp-389 440-HisSerSerIleGlyAspArg-446 489-ValLysSerGlyLysAlaIleGlyLysIleArgAlaTyr-501 504-GlnGlnAsnAlaAsp-508 521-GlnLeuAlaLysLeu-525 532-GlnGluLeuAlaGlu-536 539-GlyTyrLysLysProGluAspLeuTyrThr-548 557-AsnArgAlaIleGlnLysAlaCysGlyThrLeuAsnGluProPro-571 585-LysIleLysLysGlyGly-590 603-MetThrThrLeuAlaLysCysCysLysProAlaProProAspAspIleAlaGly-620 637-SerPheArgHisLeuAlaGluHisAlaProGluLysValLeuAspAla-652 679-ArgAspValSerAspAla-684 714-GlnValAsnAspLeuProArgValLeuAlaGlyLeuGlyAspValLysGlyValLeuSerValThrArg-73 Antigenic Index - Jameson-Wolf 5-SerProIleGlnAspThrGlnSerAlaThr-14 16-GlnGluLeuArgGluTrpPheAspSerTyrCysAlaAlaLeuProAspAsnAspLysAsnLeu-36 46-GluHisTyrProAla-50 52-AlaAlaThrProTyrGlyGluProLeuProAspHisPhe-64 70-MetValAspGluLeuAspLeuLeuPro-78 88-Aspl1eGlyArgTyrValProAspTrp-96 100-ValSerGluArgCysAsnSerThrVal-108 110-GluLeuValLysGlyValAspGluValGlnLys-120 125-AlaArgValAspSerLeuAlaThrProGluGluArgAlaGlnGlnAlaGluThrMetArg-144 162-AlaMetArgThrArgThr-167 173-AsnAlaProAspSerProGluLysArgAlaValAlaLysGluThrLeu-188 209-AspLeuGlyPheArgHisGlnGluProGluLysTyrArgGlu-222 227-LeuAspGluLysArgThrGluArgLeuGluTyr-237 245-LeuArgThrGluLeuLysLys-251 258-ValAlaGlyArgProLysHis-264 271-LyεMetValLysLysLysLeuSerPhe-279 294-ThrValProGluCysTyr-299 311-ProIleProGlyGluPheAspAspTyrIleAlaAsnProLysGlyAsnGlyTyrLysSer-330 335-IleValGlyProGluGluLysGlyValGluValGlnIleArgThr-349 364-TrpArgTyrLysGluGlyGlyLysGlyAspSerAlaTyrGluGlnLys-379 387-LeuAspTrpArgGluAsnMetAlaGluSerGlyLysGluAspLeuAlaAla-403 418-ThrProHisGlyLys-422 440-HisSerSerIleGlyAspArgCysArgGlyAlaLysValGluGly-454 461-ThrProLeuGluAsnGlyGlnArgValGluIleIleThrAlaLysGluGlyHisProSerValAsn-482 487-GlyTrpValLysSerGlyLysAlaIleGlyLys-497 502-IleArgGlnGlnAsnAlaAspThrValArgGluGluGlyArgValGlnLeuAspLysGlnLeuAla-523 525-LeuThrProLysProAsnLeuGlnGluLeuAlaGlu-536 538-LeuGlyTyrLysLysProGluAspLeu-546 551-GlyGlnGlyGluIleSerAsnArgAlaIleGlnLysAlaCysGlyThrLeuAsnGluProProProVal-57 3 582-LysGlnSerLysIleLysLysGlyGlyLysThr-592 596-IleAspGlyGluAspGlyLeu-602 608-LysCysCysLysProAlaProProAspAspIleAla-619 622-ValThrArgGluArgGlyIleSerValHisArgLysThrCysProSerPhe-638 644-HisAlaProGluLysValLeuAsp-651 667-IleGluIleArgAlaGlnAspArgSerGlyLeuLeuArgAspValSerAspAlaLeuAlaArgHisLysLeu -690 696-GlnThrGlnSerArgAspLeuGluAlaSerMet-706 710-LeuGluValLysGlnValAsnAspLeuProArg-720 726-GlyAspValLysGly-730 Hydrophilic Regions - Hopp-Woods 8-GlnAspThrGlnSer-12 16-GlnGluLeuArgGluTrpPhe-22 30-ProAspAsnAspLysAsnLeu-36 70-MetValAspGluLeuAspLeuLeuPro-78 100-ValSerGluArgCysAsnSerThr-107 110-GluLeuValLysGlyValAspGluValGlnLys-120 125-AlaArgValAspSer-129 131-AlaThrProGluGluArgAlaGlnGlnAlaGluThrMetArg-144 162-AlaMetArgThrArgThr-167 174-AlaProAspSerProGluLysArgAlaValAlaLysGluThrLeu-188 209-AspLeuGlyPheArgHisGlnGluProGluLysTyrArgGlu-222 227-LeuAspGluLysArgThrGluArgLeuGluTyr-237 245-LeuArgThrGluLeuLysLys-251 258-ValAlaGlyArgProLysHis-264 271-LysMetValLysLysLysLeuSerPhe-279 314-GlyGluPheAspAsp-318 323-ProLysGlyAsnGly-327 337-GlyProGluGluLysGlyValGluValGlnIleArgThr-349 365-ArgTyrLysGluGlyGlyLysGlyAspSerAlaTyrGluGln-378 387-LeuAspTrpArgGluAsnMetAlaGluSerGlyLysGluAspLeuAlaAla-403 443-IleGlyAspArgCysArgGlyAlaLysValGluGly-454 463-LeuGluAsnGlyGlnArgValGluIleIleThrAlaLysGluGlyHisPro-479 489-ValLysSerGlyLysAlaIleGlyLys-497 505-GlnAsnAlaAspThrValArgGluGluGlyArgValGlnLeuAspLysGlnLeuAla-523 538-LeuGlyTyrLysLysProGluAspLeu-546 553-GlyGluIleSerAsn-557 582-LysGlnSerLysIleLysLysGlyGlyLys-591 596-IleAspGlyGluAspGlyLeu-602 608-LysCysCysLysProAlaProProAspAspIle-618 622-ValThrArgGluArgGlyIleSerValHisArgLysThrCysPro-636 644-HisAlaProGluLysValLeu-650 667-IleGluIleArgAlaGlnAspArgSerGlyLeuLeuArgAspValSerAspAlaLeuAlaArgHisLysLeu -690 697-ThrGlnSerArgAspLeuGluAlaSerMet-706 710-LeuGluValLysGlnValAsnAspLeuProArg-720 726-GlyAspValLysGly-730 gllβ AMPHI Regions - AMPHI 24-GlyLysTrpTyrAsp-28 57-IleProArgAspIle-61 65-IleGlyThrIleIleAspPheLeuMetValProAsn-76 94-IleHisGluArgTyrGluArgPheThrThrMetLeuArg-106 Antigenic Index - Jameson-Wolf 2-CysGluPheLysAspPheArgArgAsnIleProCys-13 15-GluGluTyrAspGluAsnSerPhe-22 24-GlyLysTrpTyrAspAspGlyValTrpAspAspGluGluTyrTrpLysLeuGluAsnAspLeuIleGluValA rgArgLysTyrProTyrProMetAspIleProArgAspIle-61 86-ProTrpLeuProAspSerValGlyIleHisGluArgTyrGluArg-100 109-PheThrGluLysAspIleVal-115 119-PheAspTyrTyrAsnLysLys-125 Hydrophilic Regions - Hopp-Woods 2-CysGluPheLysAspPheArgArgAsnIleProCys-13 15-GluGluTyrAspGlu-19 30-GlyValTrpAspAspGluGluTyrTrpLysLeuGluAsnAspLeuIleGluValArgArgLysTyrProTyr- 53 96-GluArgTyrGluArg-100 109-PheThrGluLysAspIleVal-115 121-TyrTyrAsnLysLys-125 gl20 AMPHI Regions - AMPHI 6-LysAsnIlePheSerAla-ll 49-SerGlyAsnAlaTyrLysIleValSerThrIleLys-60 77-AsnThrLeuHisProAlaTyrTyrLysAspIleArgArg-89 142-IleThrAsnGlyLysLysLeuTyrSerValGlyGlyLeuAsnLysAlaGly-158 188-AlaProSerLeuAsnAsnIleProAla-196 Antigenic Index - Jameson-Wolf 35-SerGlySerTyrGly-39 45-ThrPheGluArgSerGlyAsnAlaTyrLys-54 68-PheGluSerGlyGlyThrValVal-75 83-TyrTyrLysAspIleArgArgGlyLysLeuTyrAla-94 97-LysPheAlaAspGlySerValThrTyrGlyLysAlaGlyGluSerLysThrGluGlnSerProLysAla-119 131-AlaAsnAspAlaLysLeuProProGlyLeuLysIleThrAsnGlyLysLysLeuTyrSer-150 153-GlyLeuAsnLysAlaGlyThrGlyLyεTyrSerIleGlyGlyValGluThrGluValValLysTyrArgVal ArgArgGlyAspAεpThrVa1-183 199-GlyTyrThrAspAspGlyLysThrTyr-207 218-GlyGlnAlaAlaLysPro-223 Hydrophilic Regions - Hopp-Woods 45-ThrPheGluArgSerGlyAsn-51 85-LysAspIleArgArgGlyLysLeuTyrAla-94 107-LysAlaGlyGluSerLysThrGluGlnSerProLysAla-119 131-AlaAsnAspAlaLysLeu-136 143-ThrAsnGlyLysLysLeuTyr-149 155-AsnLysAlaGlyThrGly-160 167-ValGluThrGluValValLysTyrArgValArgArgGlyAspAspThr-182 200-TyrThrAspAspGlyLysThrTyr-207 219-GlnAlaAlaLysPro-223 gl21-l AMPHI Regions - AMPHI 40-ProTyrProAspArgLeuArgArgLysLeu-49 68-GlnGluLeuSerArgLeuTyrAlaGlnThr-77 101-ThrValArgHisAlaPro-106 117-LeuProLeuLeuAlaGluLeuThrArgIlePheThrValGly-130 148-ProAlaPheHisGlu-152 167-IleGlyGlyIleAlaAsnIleSerVal-175 189-ProGlyAsnMetLeuMetAspAlaTrpThr-198 216-GlyAsnIleLeuProGlnLeuLeuGlyArgLeuLeuAlaHisPro-230 236-HisProLysSerThrGly-241 251-GluThrTyrLeuAsp-255 262-AspValLeuArgThrLeuSerArgPheThrAlaGlnThrValTrpAspAlaValSerHis-281 303 -AlaAspLeuAlaGluCysPhe-309 341-IleAsnArgIleProGlySerPro-348 Antigenic Index - Jameson-Wolf 13-ThrSerMetAspGlyAlaAsp-19 23-ValArgMetAspGlyGlyLysTrpLeuGly-32 40-ProTyrProAspArgLeuArgArgLysLeuLeuAspLeuGlnAspThrGlyThrAspGluLeuHisArgSerA rgMetLeuSer-67 85-GlnAsnLeuAlaProCysAsp-91 97-CysHisGlyGlnThrValArgHisAlaProGluHisGlyTyrSer-lll 128-ThrValGlyAspPheArgSerArgAspLeuAlaAlaGlyGlyGlnGly-143 154-LeuPheArgAspAspArgGluThrArgVal-163 186-AspThrGlyProGlyAsnMet-192 205-ProTyrAspLysAsnGlyAlaLysAlaAlaGlnGlyAsn-217 235-ProHisProLysSerThrGlyArgGlu-243 253-TyrLeuAspGlyGlyGluAsnArgTyrAspValLeuArgThrLeuSer-268 283-AlaAlaAspAlaArgGln-288 293-GlyGlyGlyIleArgAsnProValLeu-301 344-IleProGlySerProHisLysAlaThrGlyAlaSerLysProCysIle-359 Hydrophilic Regions - Hopp-Woods 13 -ThrSerMetAspGlyAlaAsp-19 41-TyrProAspArgLeuArgArgLysLeuLeuAspLeuGlnAspThrGlyThrAspGluLeuHisArgSerArgM etLeuSer-67 101-ThrValArgHisAlaPro-106 131-AspPheArgSerArgAspLeuAlaAla-139 154-LeuPheArgAspAspArgGluThrArgVal-163 206-TyrAspLysAsnGlyAlaLysAlaAlaGln-215 235-ProHisProLysSerThrGlyArgGlu-243 254-LeuAspGlyGlyGluAsnArgTyrAspVal-263 283-AlaAlaAspAlaArgGln-288 345-ProGlySerProHisLysAlaThrGlyAlaSerLys-356 gl22-l AMPHI Regions - AMPHI 6-AsnIleHisLysThrPhe-ll 42-ThrPheLeuArgCysLeuAsnAlaLeuGluMetProGlu-54 102-LeuGluAsnValMetGlu-107 126-LysLeuLeuGluLys-130 176-ProGluLeuValGlnAspValLeuAspAlaMetLysGluLeuAlaArgGluGly-193 227-ProLysGluLeuPheAspHisLeuLysHisGlu-237 Antigenic Index - Jameson-Wolf 5-ArgAsnIleHisLysThrPheGlyGluAsnThrIle-16 20-IleAspLeuAspValGlyLysGlyGln-28 34-GlyProSerGlySerGlyLysThrThr-42 51-GluMetProGluAspGlyGlnIleGluPheAspAsnAlaArgProLeuArgIleAspPheSerLysLysThrS erLysHisAsp-78 81-AlaLeuArgArgLysSerGlyMet-88 96-PheProHisLysThrValLeu-102 114-GlyLysProAlaAlaGlnAlaArgGluGluAlaLeuLysLeuLeuGlu-129 131-ValGlyLeuGlyAspLysValAspLeuTyr-140 142-TyrGlnLeuSerGlyGlyGlnGlnGlnArgValGlyIle-154 168-AspGluProThrSerAlaLeuAspProGluLeuVal-179 182-ValLeuAspAlaMetLysGluLeuAlaArgGluGlyTrp-194 216-MetAspGlyGlyVal-220 222-ValGluGlnGlSerProLysGluLeuPheAsp-232 234-LeuLysHisGluArgThrArgArgPheLeu-243 Hydrophilic Regions - Hopp-Woods 20-IleAspLeuAspValGlyLys-26 51-GluMetProGluAspGlyGlnIleGluPheAspAsnAlaArgProLeuArgIleAspPheSerLysLysThrS erLysHisAsp-78 81-AlaLeuArgArgLysSerGly-87 114-GlyLysProAlaAlaGlnAlaArgGluGluAlaLeuLysLeuLeuGlu-129 131-ValGlyLeuGlyAspLysValAsp-138 168-AspGluProThrSerAlaLeuAspProGluLeuVal-179 182-ValLeuAspAlaMetLysGluLeuAlaArg-191 224-GlnGlySerProLysGluLeuPheAsp-232 234-LeuLysHisGluArgThrArgArgPheLeu-243 gl26-l AMPHI Regions - AMPHI 26-LeuLysGlnSerValArg-31 73-GlyCysGlnSerValGlnGluAla-80 112-PheGlnLeuValGluAla-117 143-LeuAspAlaGlyCysGln-148 150-LeuMetProTrpAlaAlaProIleGlyThrGlyLeuGlyAlaVal-164 213-SerGlyAspProValAsnMetAlaArgAlaPhe-223 Antigenic Index - Jameson-Wolf 7-GluThrPheProSerArgLeu-13 24-GluIleLeuLysGlnSerValArgThrAlaArg-34 41-SerLeuArgArgThrGlyCysGlyGlyGluAlaHisGlyGlnGlyPhe-56 85-GlnMetAlaArgGluValPheGlu-92 99-GluLeuIleGlyAspAspAspThrLeuGln-108 121-LeuIleLysAspGlyPheLysValLeu-129 141-ArgLeuLeuAspAlaGlyCys-147 171-IleLeuArgGluArgLeuProAspThrProLeu-181 209-AlaValSerArgSerGlyAspProValAsn-218 228-GluSerGlyArgLeuAlaPhe-234 237-GlyProValGluAlaArghrLysAlaGlnAlaSerThrProThrVal-252 Hydrophilic Regions - Hopp-Woods 24-GluIleLeuLysGlnSerValArgThrAlaArg-34 41-SerLeuArgArgThrGlyCysGlyGlyGluAlaHis-52 85-GlnMetAlaArgGluValPheGlu-92 100-LeuIleGlyAspAspAspThrLeuGln-108 171-IleLeuArgGluArgLeuProAsp-178 210-ValSerArgSerGlyAspPro-216 228-GluSerGlyArgLeuAlaPhe-234 237-GlyProValGluAlaArgThrLysAlaGlnAla-247 gl27 AMPHI Regions - AMPHI 6-MetLeuAsnThrTrpProAsp-12 22-GluSerValAlaAla-26 119-ValGlyAspTyrIleGluIle-125 135-IleAsnLeuLeuAsnThrLeuMet-142 147-ProAsnProLeuValGlyGlnLeuAla-155 206-LeuGluProLeuCysAlaPro-212 214-IleProAlaIleGlnArgTyrLeuGluAsnValGln-225 250-ArgIleIleValArgPheAlaSerProVal-259 268-AlaValMetAspGluPheLeuArgVal-276 Antigenic Index - Jameson-Wolf 14-ValProIleArgAlaGluAlaAlaGlu-22 41-HisPheArgArgHisProAspPheGlyIleGluSerLysArgArgPheLeuVal-58 112-SerAlaThrGlnGlnTyrSerVal-119 126-AsnGlyLeuArgGlyArgValValAsp-134 169-HisProValArgArgAspAsnIleLeu-177 193-LeuAspSerAspGluAlaValCysArg-201 234-AlaAlaArgProArgValThrArgValProTyrAspAspLysAlaTyr-249 257-SerProValSerLyεArgLeuGluIle-265 282-AsnHisProAlaGlySerGluThrLeu-290 Hydrophilic Regions - Hopp-Woods 14-ValProIleArgAlaGluAlaAlaGlu-22 42-PheArgArgHisProAspPheGlyIleGluSerLysArgArgPheLeuVal-58 126-AsnGlyLeuArgGlyArgValVal-133 170-ProValArgArgAspAsnIleLeu-177 193-LeuAspSerAspGluAlaValCysArg-201 235-AlaArgProArgValThrArgValProTyrAspAspLysAlaTyr-249 259-ValSerLysArgLeuGluIle-265 285-AlaGlySerGluThrLeu-290 gl28-2 AMPHI Regions - AMPHI 43-AlaGlnThrHisThrGlyTrpAlaAsnThrValGluArgLeuThrGlyIleThrGluArgValGlyArgIleT rpGlyValValSerHisLeuAsnSerValVal-77 85-ValTyrAsnGluLeuMetProGluIle-93 102-GlnAspIleGluLeuTyrAsnArgPheLysThrIleLysAsnSerProGlu-118 166-PheSerGlnAsnValLeuAspAlaThrAsp-175 189-GlyIleProGluAspAla-194 218-HisTyrLeuAlaVal-222 231-LeuArgGluGlnIleTyr-236 245-GluLeuSerAsnAspGlyLysPheAspAsnThrAlaAsnIleAspArgThrLeuGluAsnAlaLeuLysThr AlaLysLeuLeuGlyPheLysAsnTyrAlaGlu-279 286-MetAlaAspThrProGluGlnValLeuAsnPheLeuHisAspLeuAlaArgArgAla-304 313-AlaGluValLysAlaPhe-318 360-LysValLeuAlaGlyLeuPheAlaGlnIleLysLysLeuTyrGly-374 472-LeuHisHisLeuLeuThrGlnValAspGluLeu-482 496-GluLeuProSerGlnPhe-501 522-GlyGluProLeuProLysGluLeuPheAspLys-532 570-TrpGlnGlnValLeuAspSerVal-577 584-IleGlnProProGluTyrAsnArgPheAlaAsnSerPheGlyHisIlePheAlaGlyGly-603 610-SerTyrAlaTrpAlaGlu-615 623-AlaAlaPheGluGluSerAspAsp-630 636-LysArgPheTrpGlnGluIleLeuAla-644 651-AlaAlaGluSerPheLysAlaPheArg-659 Antigenic Index - Jameson-Wolf 9-LeuGlyGluGluProArgPheAsnGlnIleLyεThrGluAspIleLysProAlaVal-27 32-AlaGluAlaArgGly-36 43-AlaGlnThrHisThrGlyTrp-49 52-ThrValGluArgLeuThrGlyIleThrGluArgValGlyArgIleTrp-67 77-ValAspThrProGluLeu-82 100-1leGlyGlnAspIleGluLeuTyrAsnArgPheLysThrIleLysAsnSerProGluPhe-119 123-SerProAlaGlnLysThrLysLeuAspHisAspLeuArgAsp-136 140-SerGlyAlaGluLeuProProGluArgGlnAlaGluLeuAlaLysLeuGlnThrGluGlyAlaGlnLeu-16 2 165-LysPheSerGlnAsnVal-170 172-AspAlaThrAspAla-176 190-IleProGluAspAla-194 202-AlaGlnSerGluGlyLysThrGlyTyrLys-211 225-TyrAlaGlyAsnArgGluLeuArgGluGlnIle-235 242-ArgAlaSerGluLeuSerAsnAspGlyLysPheAspAsnThrAlaAsnIleAspArgThrLeuGluAsnAla LeuLysThr-268 285-LysMetAlaAspThrProGluGln-292 300-LeuAlaArgArgAlaLysProTyrAlaGluLysAspLeuAlaGlu-314 316-LysAlaPheAlaArgGluHisLeuGlyLeuAlaAspProGlnProTrpAspLeu-333 335-TyrAlaGlyGluLysLeuArgGluAlaLysTyrAlaPheSerGluThrGluValLysLys-354 377-PheAlaGluLysThr-381 387-LysAεpValArgTyrPheGluLeuGlnGlnAεnGlyLysThrIle-401 409-TyrAlaArgGluGlyLysArgGlyGlyAla-418 420-MetAsnAspTyrLysGlyArgArgArgPheAlaAspGlyThrLeu-434 447-ProProValGlyGlyLysGluAlaArgLeuSerHisAspGlu-460 478-GlnValAspGluLeuGlyVal-484 496-GluLeuProSerGln-500 516-SerAlaHisGluGluThrGlyGluProLeuPro-526 560-SerGluSerAspGluCysArgLeuLysAsn-569 575-AspSerValArgLysGluValAla-582 585-GlnProProGluTyrAsnArgPheAlaAsnSerPheGly-597 605-SerAlaGlyTyrTyrSerTyr-611 625-PheGluGluSerAspAspValAlaAlaThrGlyLysArgPheTrp-639 646-GlyGlySerArgSerAlaAlaGluSerPheLysAlaPheArgGlyArgGluProSerIle-665 669-LeuArgHisSerGlyPheAspAsnAlaAla-678 Hydrophilic Regions - Hopp-Woods 9-LeuGlyGluGluProArgPheAsnGlnIleLysThrGluAspIleLysPro-25 32-AlaGluAlaArgGly-36 52-ThrValGluArgLeuThrGlyIleThrGluArgValGly-64 77-ValAspThrProGluLeu-82 lOO-IleGlyGlnAspIleGluLeu-106 lll-LysThrIleLysAsnSerProGlu-118 124-ProAlaGlnLysThrLysLeuAspHisAspLeuArgAsp-136 143-GluLeuProProGluArgGlnAlaGluLeuAlaLysLeuGlnThrGluGlyAlaGlnLeu-162 190-IleProGluAspAla-194 202-AlaGlnSerGluGlyLysThrGlyTyr-210 227-GlyAsnArgGluLeuArgGluGlnIle-235 242-ArgAlaSerGluLeuSerAsnAspGlyLysPheAspAsn-254 256-AlaAsnlleAspArgThrLeuGluAsnAlaLeuLysThr-268 285-LysMetAlaAspThrProGlu-291 300-LeuAlaArgArgAlaLysProTyrAlaGluLysAspLeuAlaGlu-314 316-LysAlaPheAlaArgGluHisLeuGly-324 335-TyrAlaGlyGluLysLeuArgGluAlaLysTyrAlaPheSerGluThrGluValLysLys-354 3 7-PheAlaGluLysThr-381 387-LysAspVa1ArgTyr-391 396-GlnAsnGlyLysThr-400 409-TyrAlaArgGluGlyLysArgGlyGly-417 423-TyrLysGlyArgArgArgPheAlaAsp-431 449-ValGlyGlyLysGluAlaArgLeuSerHisAspGlu-460 478-GlnValAspGluLeuGly-483 516-SerAlaHisGluGluThrGlyGluProLeuPro-526 560-SerGluSerAspGluCysArgLeuLysAsn-569 575-AspSerValArgLysGluValAla-582 625-PheGluGluSerAspAspValAlaAlaThrGly-635 647-GlySerArgSerAlaAlaGluSerPheLysAlaPheArgGlyArgGluProSerIle-665 gl30 AMPHI Regions - AMPHI 16-ThrLeuValSerGlyIle-21 36-GlySerGlySerPheGly-41 56-GlnProValGlyGlnLeu-61 91-AsnValProAsnAlaPro-96 110-GlnGlyPheAspThrLeuPheGlnHisAlaLeuAsnGlyPheAsnAlaMet-126 171-ThrAlaSerAlaPro-175 204-PheGluAlaThrCysGln-209 211-CysHisGlyGlySerIleProGlyIlePro-220 234-LysGlyLysGluThr-238 245-GluGlyPheAsnAlaMet-250 Antigenic Index - Jameson-Wolf l-MetLysGlnLeuArgAspAsnLysAlaGlnGlySer-12 35-AlaGlySerGlySerPheGlyAspValAspAlaThrThrGluAlaAlaThrGlnThrArgIleGlnProValG ly-59 63-MetGlyAspGlyIleProValGlyGluArgGlnGlyGlu-75 87-AlaAlaAspSerAsnValProAsnAlaProLysLeuGluHisAsnGlyAεpTrpAla-105 108-IleAlaGlnGlyPhe-112 126-MetProAlaLysGlyGlyAla-132 134-AspLeuThrAspGlnGluLeuLysArg-142 148-AlaAsnLysSerGlyGlySerPheProAsnProAspGluAlaAlaProAlaAspAsnAlaAlaSerGlyThr AlaSerAlaProAlaAspSerAlaAlaProAlaGluAlaLysAlaGluAspLysGlyAlaAla-192 197-GlyValAspGlyLysLysValPheGlu-205 221-GlyIleGlyLysLysAspAspTrpAlaProArgIleLysLysGlyLysGluThrLeuHis-240 251-ProAlaLysGlyGlyAsnAlaGlyLeuSerAspAspGluValLysAla-266 274-GlnSerGlyAlaLys-278 Hydrophilic Regions - Hopp-Woods 1-MetLysGlnLeuArgAspAsnLysAlaGlnGly-ll 41-GlyAspValAspAlaThrThrGluAlaAlaThr-51 68-ProValGlyGluArgGlnGlyGlu-75 87-AlaAlaAspSerAsnVal-92 96-ProLysLeuGluHisAsnGly-102 127-ProAlaLysGlyGlyAla-132 134-AspLeuThrAspGlnGluLeuLysArg-142 156-ProAsnProAspGluAlaAlaProAlaAspAsnAlaAla-168 174-AlaProAlaAspSerAlaAlaProAlaGluAlaLysAlaGluAspLysGlyAlaAla-192 198-ValAspGlyLysLysValPheGlu-205 222-IleGlyLysLysAspAspTrpAlaProArgIleLysLysGlyLysGluThrLeuHis-240 251-ProAlaLysGlyGlyAsn-256 258-GlyLeuSerAspAspGluValLysAla-266 gl32-2 AMPHI Regions - AMPHI 13-IleIleSerAlaLeuAlaVal-19 70-AlaThrCysMetAlaMetVal-76 92-IleArgGlnThrGlnGlnAlaProLysProValSerAsnThr-105 Antigenic Index - Jameson-Wolf 26-GlnHisGlyLysGlyAlaAspAla-33 38-GlySerGlySerGlySerAla-44 81-HisThrThrLysHisGlyLeuAspPheSerAsnIleArgGlnThrGlnGlnAlaProLysProValSerAsnT hrGluProSerAlaProValProGlnGlnGlnLys-116 Hydrophilic Regions - Hopp-Woods 28-GlyLysGlyAlaAspAla-33 93-ArgGlnThrGlnGlnAlaProLysProValSerAsnThrGluProSerAla-109 gl34 AMPHI Regions - AMPHI 39-IleGlnSerAlaGlyThrVal-45 47-GlyLysLysThrGly-51 56-SerAspTrpMe Aspl1eGluLysGlnArg-65 83-ValAsnLeuLeuAspThrProGlyHis-91 97-AspThrTyrArgValLeuThrAlaVal-105 114-AlaAlaLysGlyValGlu-119 123-IleLysLeuLeuAsnValCysArg-130 142-LysTyrAspArgGluVal-147 149-AspSerLeuGluLeuLeuAspGluValGluAspIleLeuGln-162 176-LysAsnPheLysGlyValTyrHisIleLeu-185 201-HisGluPheAspIleIleLysGlyIleAsnAsn-211 254-PheGlySerAlaIle-258 265-GluIleLeuAsnSerLeuIleAspTrpAlaPro-275 322-LysPheGluArgGlyMetLys-328 361-AspIleIleGlyIleProAsnHis-368 395-LeuPheArgSerValArgIleLys-402 404-ProLeuLysIleLysGln-409 411-GlnLysGlyLeuGlnGlnLeuGlyGlu-419 423-ValGlnValPheLysProMetSer-430 449-SerArgLeuAlaAsnGluTyr-455 481-AlaGluPheGluLysAlaAsn-487 515-ArgTrpProAspIle-519 Antigenic Index - Jameson-Wolf 4-GluIleLeuAspGlnValArgArgArgArgThrPhe-15 19-SerHisProAspAlaGlyLysThrThrLeuThr-29 43-GlyThrValLysGlyLysLysThrGlyLysPheAlaThr-55 57-AspTrpMetAspIleGluLysGlnArgGly-66 76-PheAspTyrLysAspHisThrVal-83 85-LeuLeuAspThrProGlyHisGlnAspPheSerGluAspThrTyrArg-100 113-AspAlaAlaLysGlyValGlu-119 129-CysArgLeuArgAspThrPro-135 140-MetAsnLysTyrAspArgGluValArgAspSerLeuGluLeuLeuAspGluValGluAsp-159 173-GlyMetGlyLysAsnPheLys-179 194-AlaGlyGlyGluArgLeuProHis-201 207-LysGlyIleAsnAsnProGluLeuGluGlnArgPheProLeu-220 223-GlnGlnLeuArgAspGluIleGluLeu-231 235-AlaSerAsnGluPheAsnLeu-241 274-AlaProAlaProLysProArgAspAlaThrMet-284 286-MetValGlyProAspGluProLysPhe-294 302-GlnAlaAsnMetAspProLysHisArgAspArgIleAla-314 317-ArgValCyεSerGlyLysPheGluArgGlyMetLysMetLysHisLeuArgIleAsnArgGluIleAla-33 9 348-SerHisAspArgGluLeuAlaGluGluAlaTyrAla-359 365-IleProAsnHisGly-369 373-IleGlyAspSerPheSerGluGlyGluGln-382 399-ValArgIleLysAsnProLeuLysIleLysGlnLeuGlnLysGlyLeuGlnGlnLeuGlyGluGluGlyAla -422 50-ArgLeuAlaAsnGluTyrGlyVal-457 459-AlaValPheAspSer-463 473-SerCysAspAspLysLysLysLeuAlaGluPheGluLysAlaAsnAla-488 503-AlaProAsnArgValAsnLeu-509 511-LeuThrGlnGluArgTrpProAspIleVal-520 523-GluThrArgGluHisSerVal-529 Hydrophilic Regions - Hopp-Woods 4-GluIleLeuAspGlnValArgArgArgArgThr-14 21-ProAspAlaGlyLys-25 43-GlyThrValLysGlyLysLysThrGlyLys-52 59-MetAspIleGluLysGlnArgGly-66 77-AspTyrLysAspHisThr-82 92-GlnAspPheSerGluAspThrTyr-99 113-AspAlaAlaLysGlyValGlu-119 129-CysArgLeuArgAspThrPro-135 142-LysTyrAspArgGluValArgAspSerLeuGluLeuLeuAspGluValGluAsp-159 194-AlaGlyGlyGluArgLeuProHis-201 212-ProGluLeuGluGlnArgPheProLeu-220 223-GlnGlnLeuArgAspGluIleGluLeu-231 277-ProLysProArgAspAlaThrMet-284 287-ValGlyProAspGluProLysPhe-294 305-MetAspProLysHisArgAspArgIleAla-314 319-CysSerGlyLysPheGluArgGlyMetLysMetLysHisLeuArgIleAsnArgGluIleAla-339 348-SerHisAspArgGluLeuAlaGluGluAlaTyrAla-359 376-SerPheSerGluGlyGluGln-382 399-ValArgIleLysAsnProLeuLysIleLysGlnLeuGln-411 417-LeuGlyGluGluGlyAla-422 473-SerCysAspAspLysLysLysLeuAlaGluPheGluLysAlaAsnAla-488 512-ThrGlnGluArgTrpPro-517 523-GluThrArgGluHiεSerVal-529 gl35-2 AMPHI Regions - AMPHI 29-ThrIleThrArgGlnLeuAlaAlaLeu-37 85-GluTyrThrAlaAεnLeu-90 169-AspIleAspGlyLeuTyrThr-175 185-ValArgLeuAspLysIleGluHis-192 212-GlyMetLeuThrLysIle-217 236-LeuLysProAspSerLeuAlaGluAlaAlaGlu-246 284-AlaGluHisAlaLeuSer-289 300-IleAlaGlyIleGluGly-305 308-SerArgMetAspThrValThrValTyr-316 318-LysAlaThrLysGlnPro-323 Antigenic Index - Jameson-Wolf 1-MetLysTyrLysArglleVal-7 14-SerIleThrArgSerAspGlySerLeuSerArgGlyLysIleGlnThrIle-30 60-GlyPheLysLysArgProValLysIleAlaAspLysGlnAlaSer-74 90-LeuSerSerAspGlyIle-95 105-AlaAspPheAlaAspLysArgArgTyrGlnAsnAlaGlyGly-118 124-LeuGlnArgArgAlaIle-129 132-IleAsnGluAsnAspThrValSerValGluGluLeuLysIleGlyAspAsnAspThrLeu-151 176-GlyAsnProAsnSerAsnProAspAlaValArgLeuAspLysIleGluHisIleAsn-194 202-GlyGlySerGlySerAlaAsnGlyThrGly-211 215-ThrLysIleLysAla-219 224-AlaGluSerGlyVal-228 233-CysSerSerLeuLysProAspSerLeuAlaGluAlaAlaGluHisGlnAlaAspGly-251 257-ArgAlaLysGlyLeuArgThrGlnLysGln-266 271-TyrSerGluSerArgGlySerValTyrValAspGluGlyAlaGluHisAlaLeuSerGluGlnGlyLyεSer LeuLeu-296 305-GlyHiεPheSerArgMetAεpThr-312 317-SerLysAlaThrLysGlnProLeuGlyLysGlyArgVal-329 335-AlaAlaGluAspLeuLeuLysSerArgLysAlaLys-346 350-IleHisArgAspAspTrpIleSer-357 Hydrophilic Regions - Hopp-Woods l-MetLysTyrLysArgIleVal-7 14-SerIleThrArgΞerAspGlySerLeuSerArgGlyLysIle-27 60-GlyPheLysLysArgProValLysIleAlaAspLysGlnAlaSer-74 105-AlaAspPheAlaAspLysArgArgTyrGlnAεn-115 124-LeuGlnArgArgAlaIle-129 133-AsnGluAsnAspThrValSerValGluGluLeuLysIleGlyAspAsnAspThrLeu-151 178-ProAsnSerAsnProAspAlaValArgLeuAspLysIleGluHisIleAsn-194 215-ThrLysIleLysAla-219 236-LeuLysProAspSerLeuAlaGluAlaAlaGluHisGlnAlaAsp-250 257-ArgAlaLysGlyLeuArgThrGlnLys-265 272-SerGluSerArgGly-276 278-ValTyrValAspGluGlyAlaGluHisAlaLeuSerGluGlnGlyLys-293 306-HisPheSerArgMetAspThr-312 318-LysAlaThrLysGlnProLeuGlyLysGlyArgVal-329 335-AlaAlaGluAspLeuLeuLysSerArgLysAlaLys-346 351-HisArgAspAspTrp-355 gl36 AMPHI Regions - AMPHI 61-AlaValAspValCysGlnArgValArgGlnPheGlyArgLysPheArgGlnLeuAlaPhe-80 100-HisHisGlyValLysGlnLeuPheLysArgPheIleIle-112 114-GlyPheLysProIleGlyArgHis-121 162-ArgHiεCysGlnAsn-166 184-GlnHisPheGlyGlnPro-189 191-GluArgCysGlnPheVal-196 Antigenic Index - Jameson-Wolf l-MetGluIleArgPhe-5 52-ArgPheValAspAspArgLeuProVal-60 64-ValCysGlnArgValArgGlnPheGlyArgLysPheArg-76 83-LeuGlnAlaAspAsn-87 113-GlyGlyPheLysProIleGlyArgHisAsnValGln-124 153-IleArgHisArgGlyGlyCysPheHisArgHisCysGlnAsnGlnProPheAsp-170 173-ThrPheGlyGlyGlyLysLeuArg-180 185-HisPheGlyGlnProValGluArg-192 198-ProAlaGlnGlnArgArgHisLysThr-206 Hydrophilic Regions - Hopp-Woods l-MetGluIleArgPhe-5 52-ArgPheValAspAspArgLeuProVal-60 64-ValCysGlnArgValArgGlnPheGlyArgLysPheArg-76 199-AlaGlnGlnArgArgHisLysThr-206 gl37 AMPHI Regions - AMPHI 24-LeuSerTyrIleLeuGlyPhe-30 49-ThrLysGluSerLeu-53 55-AspPheLeuThrTrpGly-60 78-PheSerAspTyrLeuAlaHisProLeuAspIlePheLysValTrpGluGlyGly-95 101-GlyPheLeuGlyValValIle-107 120-PheLeuLysLeuMetAspThrValAlaProLeuValPro-132 139-ArgIleGlyAsnPheIle-144 149-TrpGlyArgIleThrAspIleAsnAlaPhe-158 178-ProLeuTrpAlaGluTrpLeuGlnGlnTyr-187 190-LeuProArgHisProSerGlnLeu-197 232-TyrGlyValPheArgPheIleAlaGluPheAlaArgGlnProAspAspTyrLeuGly-250 Antigenic Index - Jameson-Wolf 36-LeuGlyArgArgArgIleAlaGln-43 48-PheThrLysGluSerLeuAspAsp-55 92-TrpGluGlyGlyMet-96 113-SerArgLysHisGlyIle-118 136-AlaSerGlyArgIle-140 166-AlaHisTyrGluAspAlaGluAlaAlaAla-175 191-ProArgHisProSerGlnLeu-197 215-SerLysLysProArgProThrGlyGln-223 241-PheAlaArgGlnProAspAspTyrLeu-249 277-PheGlyMetLysLysGlnHis-283 Hydrophilic Regions - Hopp-Woods 37-GlyArgArgArgIleAla-42 48-PheThrLysGluSerLeuAsp-54 167-HisTyrGluAspAlaGluAlaAlaAla-175 216-LysLysProArgProThrGly-222 241-PheAlaArgGlnProAspAspTyr-248 278-GlyMetLysLysGlnHis-283 gl38 AMPHI Regions - AMPHI 21-ProTyrIleArgArgPheSerGlySer-29 74-AsnAlaMetLeuGluLysVal-80 85-GluPheValGlnGlyMet-90 109-ValAsnLysGluIleValSerMetIleAsnThrTyrGly-121 152-IleGlyGlnValGlyThrValGluSerIle-161 163-ThrGlyLeuValLysGlyLeu-169 199-GlyLysLeuAlaGluGluLeu-205 213-MetThrAsnIleAlaGlyValMetAspLysThrGlyAsnLeuLeuThrLysLeuThr-231 234-ArgIleAspGlyLeu-238 247-GlyMetLeuProLysIleAlaSerAlaValGluAlaAlaValAsn-261 276-AlaLeuLeuLeuGluIlePheThrAspAla-285 Antigenic Index - Jameson-Wolf 9-AlaAlaAspLysAlaArgIleLeu-16 23-IleArgArgPheSerGlySer-29 35-TyrGlyGlyAsnAlaMetThr-41 43-ProAlaLeuLysGluGlyPheAla-50 68-GlyGlyGlyProGln-72 76-MetLeuGluLysValGlyLysLysGlyGluPhe-86 91-ArgValThrAspLysGluThrMetAsp-99 109-ValAsnLysGluIle-113 128-SerGlyArgAspAspHisPheIleLysAlaLysLysLeuLeuValAspThrProGluGlnAsnSerValAsp IleGlyGln-154 159-GluSerIleAspThrGlyLeu-165 169-LeuIleGluArgGlyCysIle-175 182-GlyValGlyGluLysGlyGluAla-189 200-LysLeuAlaGluGluLeuAsnAlaGluLys-209 219-ValMetAspLysThrGlyAsnLeuLeuThrLysLeuThrProLysArgIleAspGlyLeuIleAla-240 259-AlaValAsnGlyValLys-264 269-IleAspGlyArgLeuProAsnAla-276 291-IleLeuGlyArgGlyGluAspAla-298 Hydrophilic Regions - Hopp-Woods 9-AlaAlaAspLysAlaArgIleLeu-16 43-ProAlaLeuLysGluGlyPheAla-50 76-MetLeuGluLysValGlyLysLysGlyGluPhe-86 91-ArgValThrAspLysGluThrMetAsp-99 109-ValAsnLysGluIle-113 128-SerGlyArgAspAεpHisPheIleLysAlaLysLysLeuLeuValAspThrProGluGlnAsnSerValAsp -151 183-ValGlyGluLysGlyGluAla-189 200-LysLeuAlaGluGluLeuAsnAlaGluLys-209 219-ValMetAspLysThrGly-224 230-LeuThrProLysArgIleAspGlyLeuIle-239 269-IleAspGlyArgLeu-273 293 -GlyArgGlyGluAspAla-298 gl40 AMPHI Regions - AMPHI 10-TyrLeuAsnSerThr-14 32-PhePheLysAsnIleLysThr-38 45-SerLeuAspSerValGluLysThrAlaGly-54 68-AsnAlaAlaArgThrAlaSer-74 108-SerAlaThrProGluThrValGluThrAlaVal-118 137-AlaAlaAlaValGlnHisAlaAsnThrAlaAspGlyValArgIlePheAsnSerLeuAlaAlaThr-158 175-LeuLysAlaValSerAspGlyLeuAsp-183 189-LeuArgValIleAlaGln-194 266-IleGlyTyrLeuLysGlyLeuPheSerTyr-275 29O-GluTyrAlaGluGlySer-295 303 -LeuGlyAlaLeuGly-307 352-GlyThrLeuValGlyLeu-357 391-GlyGlyPheThrGlyAlaAla-397 425-AsnGlyTrpAsnGlyLeuAlaArg-432 Antigenic Index - Jameson-Wolf l-MetSerAlaArgGlyLysGlyAlaGly-9 12-AsnSerThrGlyArgHisVal-18 25-LysIleGlyGlnAspTyrSerPhe-32 34-LysAsnIleLysThrAspGlyGlyLeu-42 47-AspSerValGluLysThrAlaGlySerGluGlyAspThrProSer-61 63-TyrValArgArgGlyAsnAlaAlaArgThrAlaSer-74 86-HisAlaValGluGlnGlyGlySerAsnLeuGlu-96 102-LeuAspAlaSerGluSerSerAlaThrProGluThrValGlu-115 117-AlaValAlaAspArgThrAspMetProGlyIleArgLeuArgArgThrThrPhe-134 144-AsnThrAlaAspGlyValArg-150 160-TyrAlaAspSerAlaAlaAla-166 169-AspMetGlnGlyArgArgLeuLysAlaValSerAspGlyLeuAspHisAεnGlyThrGlyLeu-189 195-ThrGlnGlnAspGlyGlyThrTrpGluGlnGlyGlyValGluGlyLysMetArgGlySerThr-215 221-AlaAlaLysThrGlyGluAsnThrThr-229 236-IleGlyArgSerThrTrpSerGluAsnSerAlaAsnAlaLysThrAspSerIle-253 259-IleArgHisAspValGlyAsp-265 274-SerTyrGlyArgTyrLysAsnSerIleSerArgSerThrGlyAlaAspGluTyrAlaGlu-293 315-AlaThrGlyAspLeuThrValGluGlyGlyLeuArgHisAspLeuLeuLys-331 333-AspAlaPheAlaGluLysGlySerAlaLeuGlyTrpSerGlyAsnSerLeuThrGluGlyThr-353 362-LeuSerGlnProLeuSerAspLysAlaVal-371 376-AlaGlyValGluArgAspLeuAsnGlyArgAspTyrAla-388 399-AlaThrGlyLysThrGlyAlaArgAsnMetProHisThrArgArgValAla-415 421-ValGluPheGlyAsnGlyTrp-427 434-SerTyrThrGlySerLysGlnTyrGlyAsnHisSerGly-446 Hydrophilic Regions - Hopp-Woods l-MetSerAlaArgGlyLysGly-7 36-IleLysThrAspGly-40 47-AspΞerValGluLysThrAlaGlySerGluGlyAspThr-59 63-TyrValArgArgGlyAsnAlaAlaArgThrAlaSer-74 86-HisAlaValGluGlnGlyGlySerAsnLeu-95 102-LeuAspAlaSerGluSerSerAlaThrProGluThrValGlu-115 117-AlaValAlaAspArgThrAspMetProGlyIleArgLeuArgArgThrThrPhe-134 144-AsnThrAlaAspGly-148 169-AspMetGlnGlyArgArgLeuLysAlaValSerAspGlyLeuAspHisAsnGlyThr-187 205-GlyGlyValGluGlyLysMetArgGlySerThr-215 223-LysThrGlyGluAsnThrThr-229 244-AsnSerAlaAsnAlaLysThrAspSer-252 259-IleArgHisAspValGlyAεp-265 277-ArgTyrLysAsnSerIleSerArgSerThrGlyAlaAspGluTyrAlaGlu-293 323-GlyGlyLeuArgHisAspLeuLeuLys-331 333-AεpAlaPheAlaGluLysGlySer-340 364-GlnProLeuSerAspLysAlaVal-371 376-AlaGlyValGluArgAspLeuAsnGlyArgAεpTyrAla-388 399-AlaThrGlyLysThrGlyAlaArgAsnMetProHisThrArgArgValAla-415 gl41 AMPHI Regions - AMPHI 12-SerSerThrMetArgProIleGlyGluIle-21 32-IleGluProTyrGly-36 44-ProAlaGluAlaPheLysLeuPro-51 80-AlaAspAlaLeuArgHisIle-86 131-PheHisAlaIleGlyAla-136 139-AsnLeuLeuAlaAlaMetLeuAspAsn-147 174-GlnLeuArgAsnIleIleAspGlyMetGlyLysProValAspGlyValMetArgPro-192 212-AspIleSerAspLeuLysGluArgPheGly-221 244-AlaMetAlaAlaLeuLeuLyεAspAlaIleLysProAsnLeu-257 259-GlnThrIleGluGlyThrPro-265 272-ProPheAlaAsnIleAlaHisGlyCysAsnSerValThrAlaThrArgLeuAlaLysHisLeuAlaAspTyr Ala-296 330-AlaThrValArgAla-334 351-LeuGluAlaLeuAlaLysGlyLeuProAsnLeuLeuLysHisIleSerAsnLeuLysAsnValPheGly-37 3 406-SerLeuThrGluValTrpGlyLys-413 420-AspLeuAlaArgLysValValAsnAlaIleAspAsnGln-432 473-IleAlaSerLeuGluLys-478 502-LeuGlyCysProGluGly-507 525-ValAlaLeuCysGlyAsnMetMetLysMetProGlyLeuProLysValProAlaAla-543 Antigenic Index - Jameson-Wolf 3-PheLysThrAspAlaGluThrAlaGlnSerSerThrMetArgProIleGly-19 27-LeuAsnValAspAsnIleGluProTyrGly-36 38-TyrLysAlaLysIleAsnProAlaGluAlaPheLysLeuProGlnLysGlnGlyArg-56 64-AsnProThrProAlaGlyGluGlyLysThrThr-74 81-AspAlaLeuArgHisIleGlyLysAspSerValIleAlaLeuArgGluProSerLeuGlyPro-101 105-ValLysGlyGlyAlaAlaGlyGlyGly-113 151-GlnGlyAsnGluLeuAsnl1eAspProLysArgValLeuTrp-164 166-ArgValValAspMetAsnAspArgGlnLeuArgAsnIleIleAspGlyMetGlyLysProValAspGlyVal MetArgProAspGlyPheAspI1e-197 211-LysAspIleSerAspLeuLysGluArgPheGly-221 227-TyrAlaLysAspGlySerProValTyr-235 237-LysAspLeuLysAla-241 251-AspAlaIleLysProAsnLeu-257 287-ArgLeuAlaLysHisLeuAla-293 306-LeuGlyAlaGluLysPheCysAspIleLysCysArgLeuAlaGlyLeuLysProAspAla-325 335-LeuLysTyrAsnGlyGlyValGluArgAlaAsnLeuGlyGluGluAsnLeuGluAlaLeuAla-355 383 -PheValSerAspSerAspAlaGluLeuAlaMetIleGluLysAlaCysAla-399 411-TrpGlyLysGlyGlyAlaGlyGlyAlaAεpLeuAlaArgLysValValAsn-427 429-IleAspAsnGlnProAsnAεnPhe-436 444-LeuGlyIleLyεAεpLysIleArgAlaIleAla-454 458-TyrGlyAlaGluAspValAspPheSerAla-467 474-AlaSerLeuGluLysLeuGlyLeuAspLysMetPro-485 494-SerLeuSerAspAsnAlaLysLeu-501 503-GlyCysProGluGlyPhe-508 534-MetProGlyLeuPro-538 541-ProAlaAlaGluLysIleAspValAspGluHisGly-552 Hydrophilic Regions - Hopp-Woods 3-PheLysThrAspAlaGluThrAlaGln-ll 38-TyrLysAlaLysIleAsnPro-44 46-GluAlaPheLysLeuProGlnLysGlnGlyArg-56 67-ProAlaGlyGluGlyLysThr-73 81-AspAlaLeuArgHisIleGlyLysAspSerValIleAlaLeuArgGluProSer-98 155-LeuAsnlleAspProLysArgValLeuTrp-164 166-ArgValValAspMetAsnAspArgGlnLeuArgAsnIleIle-179 181-GlyMetGlyLysProValAspGlyValMetArgProAspGlyPhe-195 211-LysAspIleSerAspLeuLysGluArgPheGly-221 228-AlaLysAspGlySer-232 237-LysAεpLeuLysAla-241 287-ArgLeuAlaLysHisLeuAla-293 306-LeuGlyAlaGluLysPheCysAspIleLysCysArgLeuAlaGlyLeuLysProAspAla-325 339-GlyGlyValGluArgAlaAsnLeuGlyGluGluAsnLeuGluAlaLeuAla-355 383-PheValSerAspSerAspAlaGluLeuAlaMetIleGluLysAlaCysAla-399 420-AspLeuAlaArgLysValValAsn-427 444-LeuGlyIleLysAspLysIleArgAlaIleAla-454 458-TyrGlyAlaGluAspValAspPheSerAla-467 474-AlaSerLeuGluLysLeuGlyLeuAspLysMetPro-485 541-ProAlaAlaGluLysIleAspValAspGluHisGly-552 gl42 AMPHI Regions - AMPHI 26-ArgPheAlaAlaMetProAsnMetValGlyLys-36 44-GlyGlnProGlyLysMetPhe-50 100-AlaValThrProCysArg-105 107-ValCysArgAspAspMetAsn-113 118-GlyCysHisArgIleThrGluArgΞerLeuLysSerPheLeuGlnIleArgHisPheSerProLeuAsnArg -141 Antigenic Index - Jameson-Wolf 37-ProLeuPheGlyArgGlnAlaGlyGlnProGlyLysMet-49 60-HisIleAspAlaGluAlaAlaValPheArgGlnAspArgAsnAspSerArgThrPro-78 83-HisHisGlyArgArgLeuValGlyAsnArgArgAsnArgArgHisCysAsnAlaValThrProCysArgThrV alCysArgAspAspMetAsnAlaCysArgThrGlyCysHisArgIleThrGluArgSerLeuLys-128 137-SerProLeuAεnArgProLeuTyrLysAsnAlaAlaHisLysAlaSerProHis-154 Hydrophilic Regions - Hopp-Woods 42-GlnAlaGlyGlnPro-46 60-HisIleAspAlaGluAlaAlaValPheArgGlnAspArgAsnAspSerArgThr-77 84-HisGlyArgArgLeuValGlyAsnArgArgAsnArgArgHisCys-98 106-ThrValCysArgAspAspMetAsnAlaCysArg-116 121-ArgIleThrGluArgSerLeuLys-128 147-AlaAlaHisLysAlaSerPro-153 gl44 AMPHI Regions - AMPHI 36-LeuGlyGlyIleValGlnGluPhe-43 45-ValLeuAlaAspGlyVal-50 58-PheAspAspAlaAlaSer-63 71-IleAsnLysGlnIleGlyArgValAlaGlyArg-81 144-TyrArgTyrLeuSerArgHis-150 170-GlyProAlaArgCysGlySerAlaTyrSerAlaGly-181 185-SerGlyArgCysArgLysThrAlaArgLeuAsnGlyPheArgArgProArgSer-202 Antigenic Index - Jameson-Wolf l-MetSerAspThrProAlaThrArgAspPheGlyLeuIleAspGlyArgAla-17 23-LeuSerAsnArgArgGlyThr-29 47-AlaAspGlyValArgGluAsnPro-54 57-SerPheAspAspAlaAlaSerTyrAlaAspAsnProPheGlnIleAsnLysGlnIleGly-76 78-ValAlaGlyArglleArgGlyAlaAla-86 88-AspIleAsnGlyArgThrTyrArgValGluAlaAsnGluGlyArgAsnAlaLeuHisGlyGlySerHis--110 120-ValAlaAlaAspGlyArgArgLeuSerGlnArg-130 136-ProLeuGlyArgGlyArgProAlaTyr-144 146-TyrLeuSerArgHisArgAlaArgArgHisGlyValArgProAspAlaAlaHis-163 167-AlaGlyArgGlyProAlaArgCysGlySer-176 179-SerAlaGlyArgThrTyrSerGlyArgCysArgLysThrAlaArgLeuAsnGlyPheArgArgProArgSer Ile-203 Hydrophilic Regions - Hopp-Woods l-MetSerAspThrProAlaThrArgAsp-9 24-SerAsnArgArgGlyThr-29 48-AspGlyValArgGluAsnPro-54 57-SerPheAspAspAlaAlaSer-63 78-ValAlaGlyArgIleArgGlyAlaAla-86 89-IleAsnGlyArgThrTyrArgValGluAlaAsnGluGlyArgAsnAlaLeu-105 121-AlaAlaAspGlyArgArgLeuSerGln-129 138-GlyArgGlyArgProAla-143 148-SerArgHisArgAlaArgArgHisGlyValArgProAspAla-161 168-GlyArgGlyProAlaArgCys-174 182-ArgThrTyrSerGlyArgCysArgLysThrAlaArg-193 195-AsnGlyPheArgArgProArgSerIle-203 gl46 AMPHI Regions - AMPHI 20-GlnTyrGlyLeuPheAspPheMetProCys-29 34-ProLeuAspAsnPheProThrVal-41 95-LeuArgAlaCysAlaValIle-101 140-AlaArgArgMetArg-144 158-ArgHisGlnArgGlyPheAlaArg-165 Antigenic Index - Jameson-Wolf 13-IleAspHisAspLysValGluGln-20 29-CysLeuArgGlnProProLeuAspAsn-37 41-ValArgProAlaProPheGluAlaArgGlyLysHisValGluArgArgArgGlnAspLysAspThrAspSerP heArgGlnArgValAlaAsnLeuArgArgAlaLeu-76 86-AlaCysArgArgGlnArgIleHisAla-94 112-SerLeuLeuArgAspLysArgPhe-119 138-ArgArgAlaArgArgMetArgHisGlyAsnAla-148 155-GlnGlnProArgHisGlnArgGlyPheAla-164 166-AlaGlySerGlyArgAsnAspLysAspValAlaPheSerIle-179 193-ValSerGlnArgThr-197 Hydrophilic Regions - Hopp-Woods 13-IleAspHisAspLysValGluGln-20 44-AlaProPheGluAlaArgGlyLysHisValGluArgArgArgGlnAspLysAspThrAspSerPheArgGlnA rgValAlaAsnLeuArgArgAlaLeu-76 86-AlaCysArgArgGlnArgIleHisAla-94 112-SerLeuLeuArgAspLysArgPhe-119 138-ArgArgAlaArgArgMetArgHisGlyAsn-147 156-GlnProArgHisGlnArgGlyPheAla-164 167-GlySerGlyArgAsnAspLysAspValAla-176 gl48 AMPHI Regions - AMPHI 25-AlaAspLysIleArgLysIleGluAsnTrpPro-35 49-GlnSerAlaGluTyrPheArgLeuLeuValAspLeu-60 150-AlaGlyLeuGluLeuIleArgLysLeuGlyGlyGluIle-162 165-AlaAlaAlaIleLeuGluPheThrAspLeuGlnGlyGlyLysAsnIleArg-181 Antigenic Index - Jameson-Wolf 4-LysThrSerAsnLeu-8 24-LeuAlaAspLysIleArgLys11eGluAsnTrpProGlnLysGly-38 66-MetAspGlnLysIleAspIle-72 76-LeuAspAlaArgGly-80 97-ProIleArgLysLysGlyLysLeuPro-105 117-TyrGlyGluAlaAlaVal-122 124-IleHisThrAspAlaValLysProGlySerArg-134 153-GluLeuIleArgLysLeuGlyGlyGluIleValGlu-164 172-ThrAspLeuGlnGlyGlyLyεAsnIleArgAlaSerGlyAlaPro-186 192-GlnAsnGluGlyCysMetLysGly-199 Hydrophilic Regions - Hopp-Woods 24-LeuAlaAspLysIleArgLysIleGluAsnTrpPro-35 66-MetAspGlnLysIleAspIle-72 97-ProIleArgLysLysGlyLysLeuPro-105 117-TyrGlyGluAlaAlaVal-122 124-IleHisThrAspAlaValLysProGlySer-133 153-GluLeuIleArgLysLeuGlyGlyGluIleValGlu-164 178-LysAεnIleArgAlaSerGly-184 195-GlyCysMetLysGly-199 gl49 AMPHI Regions - AMPHI 72-AsnLeuGlyAspAlaLeuAspGlyValProGlyIle-83 101-ThrGlyArgArgIleLysValLeuAsnHisHisGlyGluThrGlyAspMet-117 135-GlnValGluIleLeuArgGlyProValThr-144 152-ValAlaGlyLeuValAsp-157 164-ProGluLysMetProGluAsn-170 184-AsnLeuGluLysLeu-188 220-TyrArgAsnLeuLysArgLeuProAspSerHis-230 345-PheProGlyPheGlu-349 366-AlaGlyAspAlaValGluAsnPhePheAsnAsn-376 389-ProIleGlyArgLeuLys-394 411-AlaIleProGluThrVal-416 472-GlnProLeuProAspLeuGlyAla-479 565-ArgPheGlyAsnTyrIleTyrAlaGln-573 576-AsnAspGlyArgGlyProLysSerIleGluAsp-586 627-ArgGlyArgLeuLysAsnLeuProSer-635 672-LeuThrAspArgIle-676 Antigenic Index - Jameson-Wolf 25-HisGluThrGluGln-29 40-GlyLysSerArgProArgAlaThrSerGly-49 55-ThrAlaSerAspLysIleIleSerGlyAspThrLeuArgGlnLysAla-70 97-IleArgGlyGlnThrGlyArgArgIleLysVal-107 109-AsnHisHisGlyGluThrGlyAspMetAlaAspPheSerProAspHis-124 137-GluIleLeuArgGlyPro-142 157-AspValAlaAspGlyLysIleProGluLysMetProGluAsnGlyValSerGlyGluAlaGlyLeu-178 180-LeuSerSerGlyAsnLeuGluLysLeuThrSer-190 207-GlyLeuTyrArgLysSerGlyAspTyrAlaValProArgTyrArgAsnLeuLysArgLeuProAspSerHis AlaAεpSerGlnThrGly-236 244-GlyGluLysGlyPhe-248 252-AlaTyrSerAspArgArgAspArgTyrGlyLeuProAlaHisSerHisGluTyrAspAspCysHisAla-27 4 281-SerLeuIleAsnLysArgTyrLeu-288 295-LeuThrGluGluAspIleAspTyrAspAsnProGlyLeu-307 309-CysGlyPheHisAspGlyAspGlyAlaHis-318 320-HiεThrHisAsnGlyLysProTrpIleAspLeuArgAsnLysArgTyrGluLeuArgAlaGluTrpLysGln ProPheProGly-347 354-HisLeuAsnArgAsnAspTyrHisHisAspGluLysAlaGlyAspAlaVal-370 374-PheAsnAsnLysThrHisAsnAlaArgIleGluLeuArgHisGlnProIleGlyArgLeuLysGlySerTrp -397 402-LeuGlyGlnLysSerSerAla-408 413-ProGluThrValGln-417 421-LeuIleAspAsnAsnValArg-427 437-AlaAsnTrpAspAsnPheThrLeuGluGlyGlyValArgValGluLyεGlnLysAlaΞerIleArgTyrAsp LysAlaLeuIleAspArgGluAsnTyrTyrAsnGlnProLeuProAsp-476 506-SerHisGlnGluArgLeuProSerThrGlnGluLeuTyrAlaHisGly-521 531-ValGlyAsnLysHisLeuAsnLysGluArgSerAsnAsnIle-544 549-GlyTyrGluGlyAspArgTrpGln-556 562-TyrArgAsnArgPheGlyAsn-568 574-ThrLeuAsnAspGlyArgGlyProLysSerIleGluAspAspSerGluMetLysLeu-592 594-ArgTyrAsnGlnSerGlyAlaAspPheTyrGlyAlaGluGly-607 609-11eTyrPheLysProThrProArgTyrArgl1e-619 621-ValSerGlyAspTyrValArgGlyArgLeuLysAsnLeuProSerLeuProGlyArgGluAspProTyrGly LysArgProPhe-648 651-GlnAlaAspGlnAsnAlaProArgIleProAla-661 670-ThrSerLeuThrAspArgIleAspAlaAsnLeuAspTyr-682 689-AsnLysLeuAlaArgTyrGluThrArgThrProGlyHis-701 707-GlyAlaAsnTyrArgArgAsnThrArgTyrGlyGluTrp-719 725-AlaAspAsnLeuLeu-729 739-PheLeuSerAspThrProGlnMetGlyArgSerPheThrGlyGlyVal-754 Hydrophilic Regions - Hopp-Woods 25-HisGluThrGluGln-29 40-GlyLysSerArgProArgAlaThr-47 55-ThrAlaSerAspLysIleIleSer-62 64-AspThrLeuArgGlnLysAla-70 100-GlnThrGlyArgArgIleLysVal-107 112-GlyGluThrGlyAspMetAlaAspPheSerPro-122 157-AspValAlaAspGlyLysIleProGluLysMetProGluAsnGlyValSerGly-174 181-SerSerGlyAsnLeuGluLysLeuThr-189 207-GlyLeuTyrArgLysSerGlyAsp-214 219-ArgTyrArgAsnLeuLysArgLeuProAspSerHisAlaAspSerGlnThr-235 253-TyrSerAspArgArgAspArgTyrGly-261 267-HisGluTyrAspAspCysHisAla-274 295-LeuThrGluGluAspIleAspTyrAspAsn-304 312-HisAspGlyAspGlyAlaHis-318 330-LeuArgAsnLysArgTyrGluLeuArgAlaGluTrp-341 354-HisLeuAsnArgAsnAεpTyrHisHisAspGluLysAlaGlyAspAlaVal-370 377-LysThrHisAsnAlaArgIleGluLeuArgHis-387 391-GlyArgLeuLysGly-395 446-GlyGlyValArgValGluLysGlnLysAlaSerIleArgTyrAspLysAlaLeuIleAspArgGluAsnTyr -469 506-SerHisGlnGluArgLeuProSer-513 535-HisLeuAsnLysGluArgSerAsnAsn-543 550-TyrGluGlyAspArgTrp-555 562-TyrArgAsnArgPhe-566 575-LeuAsnAspGlyArgGlyProLyεSerIleGluAspAspSerGluMetLysLeu-592 603-TyrGlyAlaGluGly-607 613-ProThrProArgTyrArgIle-619 624-AspTyrValArgGlyArgLeuLysAsn-632 637-ProGlyArgGluAspProTyrGlyLys-645 652-AlaAspGlnAsnAlaProArg-658 671-SerLeuThrAspArgIleAspAla-678 690-LyεLeuAlaArgTyrGluThrArgThrProGly-700 709-AεnTyrArgArgAεnThrArgTyrGly-717 gl50 AMPHI Regions - AMPHI 60-GlyGluIleLeuAspLeuLeu-66 87-LeuLeuSerHisPheGlu-92 100-PheValLysGlyTyrAla-105 132-IleAlaGlyValLeuHisArgPheProAlaLysLeuThrAla-145 147-GlnPheAlaGlyLeuLeuArgProLeuAla-156 235-GlyValAlaProPheArg-240 272-ThrGluTrpGlnGlnPheAlaLys-279 304-IleArgGluGlnAla-308 327-AlaAlaLysMetAlaLysGluValGluAlaAlaLeuLeuAspValIleIleGly-344 Antigenic Index - Jameson-Wolf 2-TerTyrCysLysAlaAspProPhePro-10 17-GlnLysIleThrAlaArgGlnSerAspLysAεpValArgHiεIleGluIleAεpLeuSerGlySerAspLeu- 40 43-LeuProGlyAspAla-47 52-PheAspAεnAspProAlaLeuVal-59 69-AsnProAlaThrGluIleGlnAlaGlyGlyLysThrLeu-81 93-LeuThrGlnAsnThrProAlaPhe-100 108-AlaAspAsnAspGluLeuAspArgIleAlaAla-118 163-SerSerSerGlnAlaGluAlaGlyAspGluValHis-174 181-ArgPheGluHisGluGlyArgAlaArgAlaGlyGlyAlaSerGlyPhePhe-197 199-AspArgLeuGluGluAspGlyThrVal-207 210-PheAlaGluArgAsnAspGlyPheArgLeuProGluAspSerArgLysPro-226 231-GlySerGlyThrGly-235 245-GlnArgAlaAlaGluAsnAlaGluGlyArgAsn-255 276-GlnPheAlaLysAspGlyPheLeuHisArgTyrAspPheAlaTrpSerArgAspGlnGluGluLyεIleTyr Val-300 302-AspLysIleArgGluGlnAlaGlu-309 326-AspAlaAlaLysMetAlaLysGluValGlu-335 345-AlaGlyHisSerAspGluAspGlyAlaGluGlyTyr-356 359-MetLeuArgGluGluLysArgTyrGlnArgAspValTyr-371 Hydrophilic Regions - Hopp-Woods 18-LysIleThrAlaArgGlnSerAspLysAspValArgHisIleGluIleAspLeuΞerGly-37 72-ThrGluIleGlnAlaGlyGlyLys-79 108-AlaAεpAsnAspGluLeuAspArgIleAlaAla-118 165-SerGlnAlaGluAlaGlyAspGluValHis-174 181-ArgPheGluHisGluGlyArgAlaArgAlaGlyGly-192 199-AspArgLeuGluGluAspGlyThrVal-207 210-PheAlaGluArgAsnAspGlyPheArgLeuProGluAspSerArgLysPro-226 246-ArgAlaAlaGluAsnAlaGluGlyArg-254 290-TrpSerArgAspGlnGluGluLysIleTyrVal-300 302-AspLyεIleArgGluGlnAlaGlu-309 326-AspAlaAlaLysMetAlaLysGluValGlu-335 346-GlyHisSerAspGluAspGlyAlaGluGlyTyr-356 359-MetLeuArgGluGluLysArgTyrGlnArgAspValTyr-371 gl51 AMPHI Regions - AMPHI 6-AsnIleAlaIleIleAla-ll 22-AspGlnLeuLeuArg-26 73-AspThrProGlyHis-77 81-GlyGlyGluValGluArgValLeuGlyMetValAspCysVal-94 128-LysIleAspLysPro-132 144-PheGluLeuPheAspAsnLeuGlyAlaThr-153 165-SerGlyLeuSerGlyPheAlaLysLeuGluGluThrAspGlu-178 182-MetArgProLeuPheAspThrIleLeuLysTyrThr-193 248-GlyArgIleAsnGlnLeuLeuGlyPheLysGlyLeuGluArgVal-262 273-ValIleIleSerGlyIleGlu-279 330-IleArgAspArgLeuGlnLysGluLeu-338 348-AspThrAlaAspAla-352 396-CysGluProTyrGluAsnLeuThrValAsp-405 457-LeuThrArgGlyValGly-462 464-MetSerHisValPheAsp-469 537-LysGlyLysLysLeuThrAsnIle-544 551-GluAlaValArgLeuThrThr-557 Antigenic Index - Jameson-Wolf l-MetLysGlnIleArg-5 13-ValAspHisGlyLysThrThrLeu-20 24-LeuLeuArgGlnSerGlyThrPheArgAlaAsnGlnGlnValAspGluArgValMetAspSerAsnAspLeuG luLysGluArgGlyIle-53 59-AsnThrAlaIleAspTyrGluGlyCysHis-68 72-ValAspThrProGlyHisAlaAspPheGlyGlyGluValGluArg-86 99-AspAlaGlnGluGlyProMetProGlnThrArgPheValThr-112 128-LysIleAspLysProSerAlaArgProSerTrp-138 151-GlyAlaThrAspGluGlnLeuAεp-158 171-AlaLysLeuGluGluThrAspGluSerSerAspMetArgProLeu-185 193-ThrProAlaProSerGlySerAlaAspGluProLeu-204 211-LeuAspTyrAspAsnTyrThrGly-218 226-LeuAsnGlyArgIleLysProGlyGln-234 241-HisGluGlnGlnIleAla-246 257-LysGlyLeuGluArgValProLeuGluGluAlaGluAlaGlyAsp-271 277-GlyIleGluAspIleGly-282 287-IleThrAspLysAspAsnProLysGlyLeuPro-297 300-SerValAspGluProThrLeu-306 314-ThrSerProLeuAlaGlyThrGluGlyLysPheValThrSerArgGlnIleArgAspArgLeuGlnLysGlu LeuLeu-339 344-LeuArgValGluAspThrAlaAspAlaAspValPheArgValSerGlyArgGlyGluLeu-363 371-AsnMetArgArgGluGlyTyr-377 381-ValGlyLysProArgValValTyrArgAspIleAspGlyGlnLysCysGluProTyrGluAsnLeuThrVal AspValProAspAεpAsnGlnGlyAlaValMetGluGluLeuGlyArgArgArgGlyGluLeuThrAsnMetGluS erAspGlyAsnGlyArgThrArgLeuGluTyr-440 467-ValPheAspAspTyrAlaProValLysProAspMetProGlyArgHisAsnGly-484 489-GlnGluGlnGlyGlu-493 501-AsnLeuGluAspArgGlyArgMetPheValSerProAsnAspLysIleTyr-517 524-IleHisSerArgAspAsnAspLeu-531 535-ProLeuLysGlyLysLysLeuThrAsnIleArgAlaSerGlyThrAspGluAlaValArg-554 569-PheIleAεpAspAspGluLeuValGlu-577 579-ThrProGlnSerIleArgLeuArgMet-587 591-SerGluLeuGluArgArgArgHisPheLysLysLeuAsp-603 Hydrophilic Regions - Hopp-Woods l-MetLysGlnIleArg-5 29-GlyThrPheArgAla-33 35-GlnGlnValAspGluArgValMetAspSerAsnAspLeuGluLysGluArgGlyIle-53 60-ThrAlaIleAspTyrGluGly-66 80-PheGlyGlyGluValGluArg-86 99-AspAlaGlnGluGlyProMetPro-106 128-LysIleAspLysProSerAla-134 151-GlyAlaThrAspGluGlnLeuAsp-158 171-AlaLysLeuGluGluThrAspGluSerSerAspMetArgProLeu-185 198-GlySerAlaAspGluProLeu-204 226-LeuAsnGlyArgIleLysPro-232 241-HisGluGlnGlnIleAla-246 258-GlyLeuGluArgValProLeuGluGluAlaGluAlaGlyAsp-271 277-GlyIleGluAspIleGly-282 287-IleThrAspLysAspAsnProLysGly-295 300-SerValAspGluProThrLeu-306 318-AlaGlyThrGluGlyLysPheValThr-326 328-ArgGlnl1eArgAspArgLeuGlnLysGluLeuLeu-339 344-LeuArgValGluAspThrAlaAspAlaAspValPheArgValSerGlyArgGlyGluLeu-363 371-AsnMetArgArgGluGlyTyr-377 381-ValGlyLysProArgValValTyrArgAspIleAspGlyGlnLysCysGluProTyrGlu-400 405-AspValProAspAspAsnGlnGlyAlaValMetGluGluLeuGlyArgArgArgGlyGluLeuThrAsnMet GluSerAspGlyAsnGlyArgThrArgLeu-438 472-AlaProValLysProAspMetProGlyArgHis-482 489-GlnGluGlnGlyGlu-493 502-LeuGluAspArgGlyArgMet-508 512-ProAsnAspLysIleTyr-517 525-HisSerArgAspAsnAspLeu-531 536-LeuLysGlyLysLysLeuThrAsn-543 545-ArgAlaSerGlyThrAspGluAlaValArg-554 569-PheIleAspAspAspGluLeuValGlu-577 583-IleArgLeuArgMet-587 591-SerGluLeuGluArgArgArgHisPheLysLysLeuAsp-603 gl52 AMPHI Regions - AMPHI 10-PheProThrArgLeuPhe-15 66-ArgPheSerArgPheValArgGlyTrpAlaGlyIleArgGlyTyrLeuLysAsnGlyIleProGluHisIleG lnProGlyHiεAsnProLeu-96 103-AlaLeuLeuAlaAla-107 130-LeuAsnHisLeuValSerGluHiεThrGlySerLeu-141 150-PheLyεLeuLeuAlaValPheSerAlaValHisIleAlaAlaValAlaAlaTyr-167 177-ArgProMetIleThr-181 Antigenic Index - Jameson-Wolf l-MetLysAsnLysThrLysValTrp-8 29-SerAlaLysAlaGlyGlyAsp-35 61-GlySerAεpThrAlaArgPhe-67 79-GlyTyrLeuLysAsnGlyIleProGluHisIleGlnProGlyHisAsnProLeu-96 119-AlaAsnGluAsnThrPheSerThrAsnGlyTyr-129 137-HisThrGlySerLeuIleArg-143 169-IlePheLysLysLysAsnLeuVal-176 186-IleGluGlyLysThrSerIle-192 Hydrophilic Regions - Hopp-Woods 1-MetLysAsnLysThrLysVal-7 63-AspThrAlaArgPhe-67 169-IlePheLysLysLysAsnLeuVal-176 186-IleGluGlyLysThrSerIle-192 gl53 AMPHI Regions - AMPHI 17-AlaAlaSerValLeuSerLeuProGluMetMetArgLeuMetValPhe-32 96-ThrLeuValAlaTyrIleLysLeuSerSerValAlaLys-108 130-ValSerValProGlnHisTrp-136 224-ThrIlePheSerGlyIleAlaTyr-231 274-AlaLysLysLeuSerHisLeuTyrArgIleThrGluAlaValGlyArgTrpSerMetIleAspIlePheVal Ile-298 Antigenic Index - Jameson-Wolf 65-IleArgLysGlnAla-69 81-ValArgLeuArgGln-85 143-ArgLeuThrGlyAsnAsnAla-149 151-GlnThrAlaSerGluGlyLysThrCysCysSer-161 165-TyrPheArgAspSerAlaGluSerProCysGly-175 181-LeuTyrGlyGlyArgProLysSerLeuSer-190 215-SerAsnProAlaAlaThrGlu-221 234-AspGluGlyAspArgLeu-239 272-AlaGlyAlaLysLysLeu-277 339-LeuLeuTrpAspLysArgAlaSerAspGlyIleAla-350 352-AsnGluThrGluLysTyrAsp-358 Hydrophilic Regions - Hopp-Woods 81-ValArgLeuArgGln-85 152-ThrAlaSerGluGlyLysThrCysCys-160 168-AspSerAlaGluSerPro-173 182-TyrGlyGlyArgProLysSerLeuSer-190 234-AspGluGlyAspArgLeu-239 273-GlyAlaLysLysLeu-277 339-LeuLeuTrpAspLysArgAlaSerAsp-347 352-AsnGluThrGluLysTyrAsp-358 gl54 AMPHI Regions - AMPHI 122-GlyValThrGlyLeuGlyThrLeuLeu-130 152-GlnAspIleProProValThr-158 262-ThrLysAsnSerLysAsnValLysSer-270 298-PheLysGlnSerVal-302 360-SerLysGluHisTrpLysGlnGlnPheGlnThrAlaLeuAsnLysGlyLeuThrAla-378 389-GlyLysMetIleGluLeuAsnAsp-396 429-LysLeuAlaAspLeuLeuAspLysPheAsnAsnLeuPro-441 446-ValAlaGluLeuAsnGly-451 467-LeuSerSerIleAspLysLeuValGlyAsnProGlnThrGlnAsnIleProAsnGluLeuAsnGlnThr-48 9 506-IleTyrGlyAspValGlnAsnThrLeuGlnSerLeuAspLysThrLeuLyεAspValGlnProValIleAsn ThrLeuLysGluLys-534 Antigenic Index - Jameson-Wolf l-MetThrAspAsnSerProProProAsnGlyHisAlaGlnAlaArgValArgLyεAsnAsnThr-21 43-LysGluIleArgAsnArgGlyProVal-51 57-AspSerAlaGluGlyIleGluValAsnAsnThr-67 75-AspValGlyArgValThrArgIleLysLeuArgAspAspGlnLysGlyValGlu-92 100-AspValSerGlyLeuIleArgSerAspThrGln-llO 114-ValLysProArgIleAspGlnSerGly-122 138-ThrProGlyLysSerGlyGluAlaLysAspValPheGln-150 169-LeuIleGlyLysAsnAspArgIleLeuAsn-178 196-AlaHisPheAspProSerAspGlnSer-204 212-GlnSerProAsnAspLysLeuIle-219 227-LeuGluSerGlyIleAsnIleGluThrThrGlySerGlyIleLysLeuAsnSer-244 256-SerPheAspSerProLyεThrLysAsnSerLysAsnValLysSerGluAspSer-273 275-ThrLeuTyrAspSerArgSerGluIleAlaAsnLeuProAspAspArgSerLeu-292 300-GlnSerValArgGlyLeu-305 311-ValGluTyrLysGlyLeuAsnVal-318 325-ProTyrPheAspArgAsnAspSer-332 345-IleArgIleGluProSerArgLeuGluIleAsnAlaAspGluGlnSerLysGluHisTrpLysGlnGlnPhe -368 371-AlaLeuAsnLysGlyLeu-376 386-LeuThrGlyGlyLysMetIleGluLeuAsnAspGlnProSerAlaSerProLysLeuArgPro-406 416-IleAlaThrArgGlyGlyGlyLeuAspAspLeuGlnValLysLeu-430 432-AspLeuLeuAspLysPheAεnAsnLeuProLeuAspLysThrValAla-447 450-AsnGlySerLeuAlaGluLeuLysSerAlaLeuLysSerAlaAsn-464 469-SerIleAspLysLeuValGlyAsnProGlnThrGlnAsnIleProAsnGluLeuAsnGlnThrLeuLysGlu LeuArgIle-495 500-ValSerProGlnSer-504 516-SerLeuAspLysThrLeuLysAspValGln-525 530-ThrLeuLysGluLysProAsnAla-537 541-AsnAsnSerSerLysAspProIleProLysGlySerArg-553 Hydrophilic Regions - Hopp-Woods 1-MetThrAspAsnSerProProPro-δ 12-AlaGlnAlaArgValArgLysAsnAsn-20 43-LyεGluIleArgAsnArgGly-49 57-AspSerAlaGluGlyIleGlu-63 75-AspValGlyArgValThrArgIleLysLeuArgAspAspGlnLysGlyValGlu-92 105-IleArgSerAspThr-109 116-ProArgIleAspGln-120 140-GlyLysSerGlyGluAlaLysAspValPheGln-150 171-GlyLysAsnAspArgl1eLeu-177 196-AlaHisPheAspProSerAspGln-203 214-ProAsnAspLysLeuIle-219 258-AspSerProLysThrLysAsnSerLysAsnValLysSerGluAspSer-273 278-AspSerArgSerGluIle-283 285-AsnLeuProAspAspArgSer-291 311-ValGluTyrLysGly-315 328-AspArgAsnAspSer-332 345-IleArgIleGluProSerArgLeuGluIleAsnAlaAspGluGlnSerLysGluHisTrpLys-365 390-LyεMetIleGluLeuAsnAspGlnProSerAlaSerProLysLeuArgPro-406 419- rgGlyGlyGlyLeuAspAspLeuGlnValLysLeu-430 432-AspLeuLeuAspLysPheAsn-438 441-ProLeuAspLysThrValAla-447 454-AlaGluLeuLysSerAlaLeuLysSerAlaAsn-464 469-SerIleAspLysLeuValGly-475 482-IleProAsnGluLeu-486 488-GlnThrLeuLysGluLeuArgIle-495 516-SerLeuAspLysThrLeuLysAspValGln-525 530-ThrLeuLysGluLysProAsn-536 543-SerSerLysAspProIleProLysGlySerArg-553 gl55 AMPHI Regions - AMPHI 28-LysLeuGlyPheGlu-32 42-AlaAlaSerLeuAsp-46 105-LeuArgAlaLysLysVal-llO 118-ValProArgIleSerArgAlaGlnAlaLeuAspAlaLeuSerSerMetAlaAsnIleSerGlyTyrArgAla ValIleGluAlaAlaAsnAlaPheGlyArgPhePheThrGly-155 175-ValAlaGlyLeuAlaAlaIleGlyThrAlaAsnSerLeuGlyAlaValValArgAlaPhe-194 201-AlaGluGlnIleGluSerMetGlyGly-209 225-AspGlyTyrAlaLysValMet-231 262-LysProAlaProLysLeuIleThrLysGluMetValGluSerMetLys-277 294-LeuThrArgProGlyGlu-299 307-ValLysIleIleGlyTyrThrAspMetAlaAsnArgLeuAlaGlyGln-322 329-ThrAsnLeuValAsnLeuThrLysLeuLeuSer-339 403-LysLeuAlaProAlaAlaIle-409 427-AsnHisPheIleVal-431 450-LeuHisThrProLeuMetSerValThrAsnAlaIleSerGlyIleMet-465 468-GlyAlaLeuLeuGln-472 477-AsnGlyPheValSerLeuLeuSerPheValAla-487 493-IleAsnIlePheGlyGly-498 Antigenic Index - Jameson-Wolf 4-GlyIleProArgGluSerLeuSerGlyGluThrArgVal-16 44-SerLeuAspAspAlaAla-49 72-ValAsnAlaProSerGluGlyGluLeuProLeuLeuLysGluGlyGln-87 94-TrpProArgGlnAsnGluAlaLeu-101 105-LeuArgAlaLysLysValAsn-lll 117-MetValProArgIleSerArg-123 159-AlaAlaGlyLysValProProAla-166 194-PheAspThrArgLeuGluValAlaGluGlnIleGluSerMetGlyGlyLys-210 216-PheLeuGlnGluSerGlyGlySerGlyAspGlyTyrAla-228 242-LeuPheAlaGluGlnAlaLysGluValAsp-251 259-IleProGlyLysProAlaProLysLeuIleThr-269 271-GluMetValGluSerMetLysSerGlySer-280 289-GlyGlyAsnCysGluLeuThrArgProGlyGluLeuSerVal-302 319-LeuAlaGlyGlnSerSer-324 337-LeuLeuSerProAsnLysAspGlyGluIle-346 348-LeuAspPheGluAspValIle-354 359-ThrValThrArgAspGlyGluIleThrPhePro-369 376-SerAlaArgProGlnGlnThrProSerGluLysAlaAlaProAlaAlaLysProGluProLysPro-397 Hydrophilic Regions - Hopp-Woods 4-GlyIleProArgGluSerLeuSerGlyGluThrArgVal-16 44-SerLeuAspAspAlaAla-49 7 -AlaProSerGluGlyGluLeuProLeuLeuLysGluGlyGln-87 96-ArgGlnAsnGluAlaLeu-101 105-LeuArgAlaLysLysValAsn-lll 117-MetValProArgIleSerArg-123 194-PheAspThrArgLeuGluValAlaGluGlnIleGluSerMetGly-208 220-SerGlyGlySerGlyAspGlyTyrAla-228 242-LeuPheAlaGluGlnAlaLysGluValAsp-251 260-ProGlyLysProAlaPro-265 271-GluMetValGluSerMetLysSer-278 290-GlyAsnCysGluLeuThrArgProGlyGlu-299 339-SerProAsnLysAspGlyGluIle-346 348-LeuAspPheGluAspValIle-354 359-ThrValThrArgAspGlyGluIle-366 377-AlaArgProGlnGlnThrProSerGluLysAlaAlaProAlaAlaLysProGluProLysPro-397 gl56 AMPHI Regions - AMPHI 56-AsnGlyPheGluAlaPheAlaProPhe-64 80-AlaThrValAsnThr-84 Antigenic Index - Jameson-Wolf 21-TyrAlaLysLysAlaGlyGlyPheArgPheLysAspAsnHisAsnProArgGly-38 44-GlnGlyAlaAlaAla-48 51-HisAlaAlaGlnGlnAsnGlyPheGlu-59 73-AlaThrGlyAsnAlaGlyGln-79 103-AspLysAlaAlaLeu-107 Hydrophilic Regions - Hopp-Woods 21-TyrAlaLysLysAlaGlyGlyPheArgPheLysAspAsnHisAsnPro-36 103 -AspLysAlaAlaLeu-107 gl57 AMPHI Regions - AMPHI 21-GlyArgAspValArgAlaAla-27 29-AlaIleLysIleAsnArgLeuLeuLysArgTyrIleLysArgGly-43 57-ArgLeuGlyGlyPheValArgAlaAlaGln-66 137-LeuGlyGlnAlaGlyGly-142 167-GlnLeuValAspArgLeuProArgGluAla-176 Antigenic Index - Jameson-Wolf 1-MetArgAsnGluGluLysArgAlaLeuArgArgGluLeuArgGlyArgArgSerGlnMetGlyArgAspValAr gAla-26 34-ArgLeuLeuLysArgTyrIleLysArgGlyArgLysIle-46 51-ProMetGlyLysGluLeuArg-57 64-AlaAlaGlnLysArgGlyAlaLysLeu-72 77-IleGluProHisThrArgArgMetTrp-85 87-ThrProTyrProGluArgGlyMetGluArgGluArgLysArgGlyArgAlaLysLeu-105 110-PheAlaGlyArgLysIleArgVal-117 129-GlyIleAspArgGluGlyTyrArgLeuGlyGln-139 151-MetLysTyrArgLeuGlnAla-157 168-LeuValAspArgLeuProArgGluAlaHisAspLeuProLeu-181 Hydrophilic Regions - Hopp-Woods 1-Me ArgAsnGluGluLysArgAlaLeuArgArgGluLeuArgGlyArgArgSerGlnMetGlyArgAspValAr gAla-26 34-ArgLeuLeuLysArgTyrlleLysArgGlyArgLysIle-46 64-AlaAlaGlnLysArgGlyAla-70 89-TyrProGluArgGlyMetGluArgGluArgLysArgGlyArgAlaLysLeu-105 lll-AlaGlyArgLysIleArgVal-117 129-GlyIleAspArgGluGlyTyrArg-136 151-MetLysTyrArgLeuGlnAla-157 168-LeuValAspArgLeuProArgGluAlaHisAspLeuPro-180 gl58 AMPHI Regions - AMPHI 20-PheSerArgAlaAlaGluGlnLeuGlu-28 33-AlaValSerArgIleValLysArgLeuGlu-42 46-GlyValAsnLeuLeuAsnArgThrThrArgGlnLeuAsn-58 63-GlyAlaGlnTyrPheArgArgAlaGlnArgIleLeuGlnGlu-76 85-LeuAlaValHisGluValProGln-92 160-PheAspSerHisPheArgValValAlaSerPro-170 178-ThrProGlnSerAlaGluAspLeu-185 188-HisGlnCysLeuGlyPheThrGluProGlySerLeuAsnThrTrpAlaVal-204 287-AspPheLeuValLysGluLeuGlyLysAsnMetAsnArgThrAsnThr-302 Antigenic Index - Jameson-Wolf l-MetLysThrAsnSerGluGluLeu-8 16-GluSerGlySerPheSerArgAlaAlaGluGlnLeuGluMetAlaAsn-31 36-ArgIleValLysArgLeuGluGluLysLeuGly-46 49-LeuLeuAsnArgThrThrArgGlnLeuAsnLeuThrGluGluGlyAlaGlnTyrPheArgArgAlaGlnArgI leLeuGln-75 78-AlaAlaAlaGluThrGluMet-84 95-LeuArgValAspSer-99 114-LysPheAsnGluArgTyrProHisIleArg-123 136-IleGluArgLysValAspIle-142 144-LeuArgAlaGlyGluLeuAspAspSerGlyLeuArgAla-156 168-AlaSerProGluTyrLeuAla-174 176-HisGlyThrProGlnSerAlaGluAspLeuAla-186 192-GlyPheThrGluProGlySerLeuAsn-200 207-AlaGlnGlyAsnProTyrLysIle-214 216-ProHisPheThrAlaSerSerGlyGluIleLeu-226 229-LeuCysLeuSerSerCysGly-235 243-LeuValAspAsnAspIleThrGluGlyLysLeu-253 258-AlaGluGlnThrSerAsnLysThrHisProPhe-268 273-TyrSerAspLysAlaValAsnLeu-280 292-GluLeuGlyLysAsnMetAsnArgThrAsnThrLys-303 Hydrophilic Regions - Hopp-Woods l-MetLysThrAsnSerGluGluLeu-8 19-SerPheSerArgAlaAlaGluGlnLeuGluMet-29 36-Argl1eValLysArgLeuGluGluLysLeuGly-46 58-AsnLeuThrGluGluGlyAlaGlnTyrPheArgArgAlaGlnArgIleLeuGln-75 78-AlaAlaAlaGluThrGluMet-84 95-LeuArgValAspSer-99 114-LysPheAsnGluArgTyrPro-120 136-IleGluArgLysValAspIle-142 144-LeuArgAlaGlyGluLeuAspAspSerGlyLeuArgAla-156 180-GlnSerAlaGluAspLeuAla-186 246-AsnAspIleThrGluGlyLysLeu-253 260-GlnThrSerAsnLysThrHis-266 276-LysAlaValAsnLeu-280 292-GluLeuGlyLysAsnMetAsnArgThrAsnThrLys-303 gl60 AMPHI Regions - AMPHI 6-LysLeuValAspLeuAlaGlnLeuThrGly-15 27-TrpHisGluThrLeu-31 69-GlyLeuGlyHisVal-73 97-LysGlnCysGlyAsn-101 118-AlaAspLeuMetAsnGlyLeuProGluThr-127 154-GlyThrValSerValValAsnAlaLeuProSer-164 183-LeuSerGlyValLeuLysGlyTrpGlnAspLysArg-194 197-HisLeuIleGlnLysValIleAspLysProGlu-207 216-ValAlaAlaAlaAsn-220 226-LeuMetArgArgPheLysSer-232 239-HisAlaPheValAsnHisIleArg-246 276-PheGlyLysAlaPheLys-281 Antigenic Index - Jameson-Wolf 2-AspIleLeuAspLysLeuValAsp-9 13-LeuThrGlySerAlaAspVal-19 30-ThrLeuGlnArgGluGlyLeu-36 49-IleAspGlyGluThrSerProArgProValGlyThrGlyAsp-62 74-LeuSerHisAspGlyLysTyrGlyGluSerLeuGlnProAspIleArgGlnAsnGlyThrPhe-94 98-GlnCysGlyAsnGlyLeu-103 112-PheArgTyrAspThrHisAla-118 120-LeuMetAsnGlyLeu-124 146-LeuGluSerGluLysProLeu-152 175-LeuGluGlnAspLysAspValGluLeu-183 189-GlyTrpGlnAspLysArgLeuGly-196 202-ValIleAspLysProGluAspGluTrpAsnIleAspLysMetVal-216 225-GlnLeuMetArgArgPheLysSerGlnVal-234 252-LeuLeuLeuLysLysThrProAspSerValLeu-262 271-GlnSerGluThrHisPhe-276 278-LysAlaPheLysArg-282 287-SerProGlyGlnTyrArgLysGluGlyGlyGlnLys-298 Hydrophilic Regions - Hopp-Woods 2-AspIleLeuAspLysLeuValAsp-9 30-ThrLeuGlnArgGluGlyLeu-36 50-AspGlyGluThrSerProArgProValGly-59 76-HisAspGlyLysTyrGlyGlu-82 84-LeuGlnProAspIleArgGln-90 146-LeuGluSerGluLysProLeu-152 175-LeuGluGlnAspLysAspValGluLeu-183 190-TrpGlnAspLysArgLeuGly-196 202-ValIleAspLysProGluAspGluTrpAsnIle-212 225-GlnLeuMetArgArgPheLysSer-232 255-LysLysThrProAspSerValLeu-262 278-LysAlaPheLysArg-282 290-GlnTyrArgLysGluGlyGlyGlnLys-298 gl63 AMPHI Regions - AMPHI 60-SerGlyLeuGlyAsnIle-65 67-LeuGlyArgAspGluAsp-72 76-PheGlyPheLeuSerTrpLeuAlaMetLeuPhe-86 100-AlaGluProLeuMetHisTyrPheSerAspIle-llO 170-IleSerGlyArgPheGlyAspAlaIleAspIleMetAlaLeuLeuAlaThrPhePheGlyIleIleThrThr -193 227-MetSerLeuAlaValValSerAlaIleSerGlyValGlyLysGlyValLysValLeuSer-246 272-AlaPheGlyAspAsnIleGlyAsnTyrLeuGlyAsnLeuValArg-286 313-TrpCysSerTrpAlaProPheValGlyLeuPheIleAla-325 346-LeuPheGlyValLeuTrpPhe-352 367-AlaGlyGlyMetLeuGluLysMetThrSerSer-377 380-ThrLeuLeuPheLysPhePheAsnTyrLeuProLeuProGluLeuThrSerIleValSerLeuLeu-401 438-TrpGlyValLeuMetSerAla-444 454-GlyLeuGlyAsnLeuGlnSerMetThrLeu-463 510-ArgLeuValArgIleMetSer-516 520-GluGlnAspIleLeuLysPheLeuLysHisThrAla-531 535-MetHisGluLeuGlnArgGluLeu-542 574-AspPheMetTyrGlyIle-579 583-GlyGlnAspValSerAspGlnLeu-590 630-AlaAspIleLeuLysAsnTyr-636 Antigenic Index - Jameson-Wolf 29-AspArgAlaLysGlu-33 65-IleArgLeuGlyArgAspGluAspValPro-74 114-AlaProGluHisArgGlnGln-120 166-LeuLysGluLysIleSerGlyArgPheGlyAspAlaIleAsp-179 200-GlnLeuGlyAlaGlyLeu-205 237-GlyValGlyLysGlyValLysVal-244 293-AlaTyrGluArgGluHisLysProTrpPhe-302 326-ArgIleSerLysGlyArgThrIleArg-334 370-MetLeuGluLysMetThrSerSerProGlu-379 409-ThrSerAlaAspSerGlyIle-415 421-IleThrSerArgAspLysGlyLeuSerAlaProArgTrp-433 451-ArgSerGlyGlyLeuGlyAsn-457 484-LeuSerAlaAspLysLysTyrPheGluThrArgValAsnProThrSer-499 503-ThrGlyGlyLysTrpLysGluArgLeuVal-512 516-SerGlnThrGlnGluGlnAspIle-523 537-GluLeuGlnArgGluLeuSerGluGluTyrGlyLeu-548 550-ValArgValAspLysMetPheHisGlnAspGluProAla-562 566-ValIleArgLysGluThrMetArg-573 581-SerValGlyGlnAspValSerAspGlnLeuIleAsnAspGlyLysLeuProHisIleArgHisGlnThrThr TyrLysProTyr-608 612-PheAspGlyArgValGlyTyr-618 622-TyrMetAsnLysAspGluLeuIle-629 632-1leLeuLysAsnTyrGlu-637 654-GluGlnValGluLeuAlaGlu-660 Hydrophilic Regions - Hopp-Woods 29-AspArgAlaLysGlu-33 66-ArgLeuGlyArgAspGluAspValPro-74 114-AlaProGluHisArgGlnGln-120 166-LeuLysGluLysIleSerGlyArgPheGlyAsp-176 238-ValGlyLysGlyValLysVal-244 293-AlaTyrGluArgGluHisLysPro-300 327-IleSerLysGlyArgThrIleArg-334 370-MetLeuGluLysMetThrSerSerPro-378 422-ThrSerArgAspLysGlyLeuSer-429 484-LeuSerAlaAspLysLysTyrPheGlu-492 506-LysTrpLysGluArgLeuVal-512 516-SerGlnThrGlnGluGlnAspIle-523 537-GluLeuGlnArgGluLeuSerGluGluTyrGlyLeu-548 550-ValArgValAspLysMetPheHisGlnAspGluProAla-562 566-ValIleArgLysGluThrMetArg-573 581-SerValGlyGlnAspValSerAsp-588 590-LeuIleAsnAspGlyLysLeuProHis-598 622-TyrMetAsnLysAspGluLeuIle-629 654-GluGlnValGluLeuAlaGlu-660 gl64 AMPHI Regions - AMPHI 12-TyrIleLeuAsnAspCys-17 28-LeuSerLysGluLeuAlaGlyLeuLysAla-37 62-PhePheGluAsnValArgArgPheProGlu-71 75-LeuGlyArgGlnProArgIleAsnAspLeuAlaHis-86 104-TyrAlaAsnLeuPheAlaAsnLeuAsnGlyIleGluArgIlePheLys-119 179-ValProAlaIleTyrThr-184 197-TrpPheAsnArgIle-201 226-AlaLysLeuLeuGluGlyTyrGlyLeuSer-235 277-GluValGlyGluLeuIle-282 289-MetArgGlyTyrLeuAsn-294 302-ThrIleValAsnGlyTrpLeuLys-309 339-ValTyrProArgGluIleGluGluGlu-347 349-HisLysLeuAspAlaValGluAlaAlaAla-358 374-PheValGlnLeuLysGluGlyMet-381 387-GluIleArgArgHisLeuArgThrVal-395 399-PheLysIleProLysGln-404 414-AsnAlaThrGlyLysValLeuLysArgValLeuLysGluGlnPheGluGlyAsn-431 Antigenic Index - Jameson-Wolf 5-LeuLysAsnSerGlu-9 15-AsnAspCysLysAla-19 27-GlyLeuSerLysGluLeuAlaGly-34 37-AlaGlnThrProValGlu-42 45-IleTrpThrAspLysSerArgProAlaGlyGluThrAlaGluGly-59 65-AsnValArgArgPheProGluLysProAspLeuGlyArgGlnProArgIleAsnAsp-83 90-ThrSerGlyThrThrGlyHisProLysGlyAla-100 112-AsnGlyIleGluArgIlePheLysIleSerLysArgAspArgPhe-126 205-IleSerGlyGlyAlaProLeuAla-212 219-PheLysAlaLysPheProArg-225 230-GluGlyTyrGlyLeuSerGluAlaSer-238 245-ThrProGluArgGlnLysAlaArgSerVal-254 258-LeuProGlyLeuGluAlaLysAlaValAspGluGluLeuValGluValProArgGlyGluValGly-279 282-IleValArgGlyGlySerValMet-289 297-AlaAlaThrAspGluThrIle-303 306-GlyTrpLeuLysThrGlyAsp-312 315-ThrIleAspGluAspGly-320 325-ValAspArgLysLysAspLeuIleIleSerLysGlyGlnAsnValTyrProArgGluIleGluGluGluIle HisLys-350 361-GlyValLysAspArgTyrAlaAspGluGluIle-371 377-LeuLysGluGlyMetAspLeuGlyGluAspGluIleArgArgHisLeu-392 405-IleHisPheLysAspGlyLeuProArgAsnAlaThrGlyLysValLeuLysArgValLeuLysGluGlnPhe GluGlyAsnLys-432 Hydrophilic Regions - Hopp-Woods 27-GlyLeuSerLysGluLeuAlaGly-34 48-AspLysSerArgProAlaGlyGluThrAlaGluGly-59 65-AsnValArgArgPheProGluLysProAspLeuGlyArgGlnProArgIleAsnAsp-83 113-GlyIleGluArgIlePheLysIleSerLysArgAspArgPhe-126 219-PheLysAlaLysPheProArg-225 245-ThrProGluArgGlnLysAlaArgSer-253 261-LeuGluAlaLysAlaValAspGluGluLeuValGluValProArgGlyGluValGly-279 297-AlaAlaThrAspGluThrIle-303 315-ThrIleAspGluAspGly-320 325-ValAspArgLysLysAspLeuIleIle-333 340-TyrProArgGluIleGluGluGluIleHisLys-350 361-GlyValLysAspArgTyrAlaAspGluGluIle-371 377-LeuLysGluGlyMetAspLeuGlyGluAspGluIleArgArgHisLeu-392 409-AspGlyLeuProArgAsnAlaThr-416 418-LysValLeuLysArgValLeuLysGluGlnPheGluGlyAsnLys-432 gl65-l AMPHI Regions - AMPHI 17-AlaThrLeuGlyValLeuLeuLysGluLeu-26 33-ThrLeuIleGluArgLeuGluAsp-40 73-IleAsnProAlaArgAlaLeuAsnIleAla-82 90-GlnPheTrpAlaThr-94 108-AsnAlaValProHis-112 121-HisCysArgTyrLeuGlnLysArg-128 130-AspValPheLysThrGlnLysLeuPheGluAsnMet-141 182-ArgLeuThrArgGlnMetValLysTyrLeuGlnGly-193 198-ThrGluPheAsnArgHisValGluAspIleLysArgGlu-210 364-LysThrLysGluGlu-368 371-AlaSerLeuLeuGluTyrTyrProArgGln-380 Antigenic Index - Jameson-Wolf l-MetAlaGluAlaThrAsp-6 24-LysGluLeuGluProSerTrp-30 36-GluArgLeuGluAspValAlaLeuGluSerSerAsnAlaTrpAsnAsnAlaGlyThrGly-55 97-AlaGluGlyLysLeuGluAspAsnSer-105 117-Me AsnGluAspHisCysArgTyrLeuGlnLysArgTyrAspValPheLysThrGlnLysLeuPheGlu-13 9 141-MetGluPheSerThrAspArgAsnLysIleSerAsp-152 157-IleMetArgGlyArgAspGluAsnGlnPro-166 169-AlaAsnTyrSerAlaGluGlyThrAspValAspPheGlyArgLeuThrArgGlnMet-187 191-LeuGlnGlyLysGlyValLysThrGluPheAsnArgHisValGluAspIleLysArgGluSerAspGly-21 3 219- hrAlaAspThrArgAsnProAspTrp-227 249-GlnLysSerGlyIleProGluGlyLysGlyTyrGlyGly-261 269-PheArgAsnSerAsnProGluThrAlaGluGlnHisAsn-281 300-LeuAspThrArgAsnValAspGlyLysArgHisLeu-311 322-AsnPheLeuLysGlnGlySerPheMet-330 361-GluLeuArgLysThrLysGluGluArgPhe-370 375-GluTyrTyrProArgGlnThrArgArg-383 395-11eXxxTyrAspSerLysLeuArgVal-403 410-ValProArgAspAlaArgSerArgIleLeuGluArgArgGlyAlaSerArg-426 430-IleSerAlaAspAspThrAlaProSer-438 Hydrophilic Regions - Hopp-Woods l-MetAlaGluAlaThrAsp-6 24-LysGluLeuGluPro-28 36-GluArgLeuGluAspValAlaLeuGluSer-45 97-AlaGluGlyLysLeuGluAspAsnSer-105 117-MetAsnGluAspHisCysArgTyrLeuGlnLysArgTyrAspVal-131 141-MetGluPheSerThrAspArgAsnLysIleSerAsp-152 158-MetArgGlyArgAspGluAsnGlnPro-166 172-SerAlaGluGlyThrAspValAspPhe-180 182-ArgLeuThrArgGlnMet-187 194-LysGlyValLysThrGluPheAsnArgHisValGluAspIleLysArgGluSerAspGly-213 219-ThrAlaAspThrArgAsnProAsp-226 252-GlyIleProGluGlyLysGly-258 272-SerAsnProGluThrAlaGluGlnHisAsn-281 300-LeuAspThrArgAsnValAspGlyLysArg-309 361-GluLeuArgLysThrLysGluGluArgPhe-370 378-ProArgGlnThrArgArg-383 397-TyrAspSerLysLeuArg-402 410-ValProArgAspAlaArgSerArgIleLeuGluArgArgGlyAlaSerArg-426 431-SerAlaAspAspThrAlaPro-437 g204 AMPHI Regions - AMPHI 16-HisIleAlaSerValLeuHisGlyGly-24 45-GlnPheAlaAlaValPheGlyAspIleAlaHisGlnPheGly-58 89-ValValGlyMetLeuSerGlyGln-96 104-GlnAlaPheAsnArgIleThrAspLeuPhePhe-114 132-ArgArgIleValAspValPheAsp-139 144-PheArgArgAlaLeuCysArglleLeuArgLeuPheArgArgllePheGly-160 229-ArgAlaPheCysAla-233 Antigenic Index - Jameson-Wolf 4-AlaGluIleLysArgProLeu-10 34-LeuGlnGlyGlyMetArgAsnGlnVal-42 55-HisGlnPheGlyLys-59 68-ArgProAlaArgArgArgValLeu-75 82-PheAlaAspAspGlyPheGln-88 93-LeuSerGlyGlnProAspGlyValLeu-101 125-SerGlnSerGlnThrGlyAsnArgArgIleValAsp-136 138-PheAspPheGluAsnArgPheArgArgAlaLeu-148 162-AlaAlaGlyGlyLysGlnGlnAla-169 172-GlnHisGlyLysArgTyrPhe-178 187-SerLysCysArgLeuLysCysArgLeuLysArgGlyArgArgArgPheGlyArgHisTrp-206 209-PheAsnGlyArgMetProThrAlaSerArgThrLeuSerAsnAsnSerArgAlaSerLeu-228 Hydrophilic Regions - Hopp-Woods 4-AlaGluIleLysArgProLeu-10 68-ArgProAlaArgArgArgValLeu-75 83-AlaAspAspGlyPhe-87 128-GlnThrGlyAsnArgArgIleValAsp-136 138-PheAspPheGluAsnArgPheArgArgAlaLeu-148 165-GlyLysGlnGlnAla-169 172-GlnHisGlyLysArgTyrPhe-178 187-SerLysCysArgLeuLysCysArgLeuLysArgGlyArgArgArgPheGly-203 213-MetProThrAlaSerArgThrLeuSerAsnAsnSerArgAlaSerLeu-228 g205-l AMPHI Regions - AMPHI 6-PheAlaValLeuGlyGly-ll 21-SerGluAsnThrAlaGluGlnProGlnAsnAlaAlaGlnSer-34 87-GlyLysHisProAsnAspLeuGluAlaValValGlyLys-99 119-HisThrLeuPheAlaLysLeuValGlyAsnIleAlaGluAspGlyGlyLys-135 147-GlnProTyrGlnAla-151 Antigenic Index - Jameson-Wolf 18-CysGlyLysSerGluAsnThrAlaGluGlnProGlnAsnAlaAlaGlnSerAlaProLysProValPhe-40 56-GlyGlnSerSerGluGlyLysThrAsnAspGlyLysLysGlnIle-70 73-ProIleLysGlyLeuProGluGlnAsnAla-82 85-LeuThrGlyLysHisProAsnAspLeuGluAlaValVal-97 99-LysCysMetGluThrAspGlyLysAspAlaProSerGlyTrpAlaGluAsnGly-116 129-IleAlaGluAspGlyGlyLysLeuThr-137 149-TyrGlnAlaGlyLysSerGlyTyr-156 168-IleAspSerGluGlyAlaPhe-174 Hydrophilic Regions - Hopp-Woods 19-GlyLysSerGluAsnThrAlaGluGlnProGln-29 57-GlnSerSerGluGlyLysThrAsnAspGlyLysLysGlnIle-70 85-LeuThrGlyLysHisProAsnAspLeuGluAlaValVal-97 99-LysCysMetGluThrAspGlyLysAspAlaPro-109 129-IleAlaGluAspGlyGlyLysLeu-136 150-GlnAlaGlyLysSerGly-155 168-IleAspSerGluGlyAlaPhe-174 g206 AMPHI Regions - AMPHI 32-ProLysGlnThrValArgGlnIleGlnAlaVal-42 44-IleSerHisIleGlyArgThrGln-51 81-CysSerGlyMetIleGln-86 99-ArgThrAlaArgAspMet-104 150-SerGlyLysThrIleLysThrGlu-157 Antigenic Index - Jameson-Wolf 2-PheSerProAspLysThrLeu-8 21-GlyThrThrSerGlyLysHisArgGlnProLysProLysGlnThrValArg-37 48-GlyArgThrGlnGlySerGlnGluLeu-56 66-ThrProTyrLysTrpGlyGlySerSerThr-75 96-LysLeuProArgThrAlaArgAspMetAlaAlaAlaSerArgLysIleProAspSerArgLeuLysAlaGly- 119 126-ThrGlyGlyAlaHisArgTyrSer-133 146-HisAlaProGlySerGlyLysThrIleLysThrGluLysLeuSer-160 Hydrophilic Regions - Hopp-Woods 23-ThrSerGlyLysHisArgGlnProLysProLysGlnThrVal-36 48-GlyArgThrGlnGlySerGln-54 96-LysLeuProArgThrAlaArgAspMetAlaAlaAlaSerArgLysIleProAspSerArgLeuLysAlaGly- 119 149-GlySerGlyLysThrIleLysThrGluLysLeuSer-160 g211 AMPHI Regions - AMPHI 18-ValGlyAsnGlyValAspLysPheGlyArgGlyAla-29 57-GlnPheGluArgAla-61 99-LysGlyPheAspGluIleAsnProAla-107 109-AlaLeuAlaGlnValIleGluLeu-116 153-AspGlyLysArgHisGlyLysLeuHis-161 Antigenic Index - Jameson-Wolf 8-AsnGlnLeuGlyGlyArgAsnGlyAlaAlaVal-18 20-AsnGlyValAspLysPheGlyArgGlyAlaAspAsnGlnValGluPheLeuGlu-37 44-GlyAlaSerGlyArgAlaAla-50 73-GlyGluAspAspValVal-78 99-LysGlyPheAspGluIleAsnPro-106 140-CysProArgTyrHisProLysLeuHisAspGlyAsnGlnAspGlyLysArgHisGlyLysLeuHisAspGly AlaTyr-165 169-GlnArgGlnSerAlaGly-174 Hydrophilic Regions - Hopp-Woods 10-LeuGlyGlyArgAsnGlyAla-16 21-GlyValAspLysPheGlyArgGlyAlaAspAsnGlnValGluPheLeuGlu-37 73-GlyGluAspAspValVal-78 100-GlyPheAspGluIleAsn-105 143-TyrHisProLysLeuHisAspGlyAsnGlnAspGlyLysArgHisGlyLysLeuHisAsp-162 g212 AMPHI Regions - AMPHI 6-TrpAspGlylleProAspIleArgThr-14 16-AspGlnThrIleArgLysHisAlaHis-24 40-PheGlnThrAlaGln-44 63-CysLeuGlnPheAspSerIleAsnLeuIleGluHisIle-75 89-ThrArgArgLeuHisGluHis-95 142-AlaΞerThrAlaHis-146 199-ArgLeuLeuGlyHis-203 238-HisAsnHisLeuTyrArgSerIleThrSerAlaGluAlaGluLysIle-253 262-TyrAlaGluProLeuCysGlyLeu-269 288-SerHisProLeuIleGluLeu-294 296-GluAsnThrThrLeu-300 397-TrpAsnGluAlaGluGluAla-403 Antigenic Index - Jameson-Wolf 8-GlyIleProAspIleArgThrLeuAspGlnThrIleArgLysHisAlaHisProLeu-26 33-ProAspAsnGlnIleProAspPheGlnThrAlaGlnAspAlaSerAspSerGluCysArgLeuLysHisArgL euAspGln-59 85-ProProSerArgThrArgArgLeuHisGlu-94 105-AlaIleProGlnThrGluSerLysSerAspLysProTrp-117 122-GlnThrSerGluArgLysLysProGluHis-131 158-LeuGluAlaArgLysAlaAlaGln-165 168-SerGlyAsnArgGlnGly-173 180-SerProHisAspThrGlyGlnThrGlu-188 193-GlyTyrGlyTyrThrLysArgLeuLeu-201 205-LeuProAspSerAspThrTrpGlyGlyAsn-214 220-AsnTyrSerArgThrGluGlnGlnArgAsnHxsGluLeuGlyLeu-234 246-ThrSerAlaGluAlaGluLysIleAla-254 258-LeuAsnThrProTyrAlaGluProLeu-266 303-IleSerHisAspGlyGluLysTrpIle-311 328-ThrGlyAlaHisSerProCysLeuPro-336 346-ArgGlnIleArgGlyGlnThrGlyLeuThrProSerThrProPheSerGluGlnLeuArg-365 376-ProSerTrpHxsGly-380 391-AsnSerSerAsnThrGlyTrpAsnGluAlaGluGluAlaSerAsnArgGlnAla-408 Hydrophilic Regions - Hopp-Woods 10-ProAspIleArgThrLeuAspGlnThrIleArgLysHisAla-23 44-GlnAspAlaSerAspSerGluCysArgLeuLysHxsArgLeuAspGln-59 87-SerArgThrArgArgLeuHisGlu-94 105-AlaIleProGlnThrGluSerLysSerAspLys-115 122-GlnThrSerGluArgLysLysProGluHis-131 158-LeuGluAlaArgLysAlaAlaGln-165 180-SerProHxsAspThrGlyGln-186 206-ProAspSerAspThr-210 222-SerArgThrGluGlnGlnArgAsnHisGlu-231 246-ThrSerAlaGluAlaGluLysIleAla-254 304-SerHxsAspGlyGluLysTrpIle-311 346-ArgGlnIleArgGly-350 398-AsnGluAlaGluGluAlaSerAsnArgGlnAla-408 g214-l Hydrophilic Regions - Hopp-Woods 10-ProAspIleArgThrLeuAspGlnThrIleArgLysHxsAla-23 44-GlnAspAlaSerAspSerGluCysArgLeuLysHxsArgLeuAspGln-59 87-SerArgThrArgArgLeuHisGlu-94 105-AlaIleProGlnThrGluSerLysSerAspLys-115 122-GlnThrSerGluArgLysLysProGluHis-131 158-LeuGluAlaArgLysAlaAlaGln-165 180-SerProHisAspThrGlyGln-186 206-ProAspSerAspThr-210 222-SerArgThrGluGlnGlnArgAsnHisGlu-231 246-ThrSerAlaGluAlaGluLysIleAla-254 304-SerHisAspGlyGluLysTrpIle-311 346-ArgGlnIleArgGly-350 398-AsnGluAlaGluGluAlaSerAsnArgGlnAla-408 Antigenic Index - Jameson-Wolf 23-LeuGlnSerAspSerArgArgProIleGlnIleGluAlaAspGlnGlySerLeuAspGlnAlaAsnGlnΞerT hrThrPheSerGlyAsn-52 71-ArgGlyGlyLysGlyGlyGluSerValArgAlaGluGlySerProValArgPheSerGlnThrLeuAspGlyG lyLysGlyThrValArgGlyGlnAlaAsnAsnVal-106 119-GlyAsnAlaLysValGlnArgGlyGlyAspValAlaGlu-131 138-AsnThrLysThrGluVal-143 148-GlySerThrLysSerGlyAlaLysSerAlaSerLysThrGlyArgVal-163 169-ProSerSerThrGlnLysThrGlu-176 Hydrophilic Regions - Hopp-Woods 25-SerAspSerArgArgProIleGlnIleGluAlaAspGlnGlySerLeuAspGlnAlaAsn-44 71-ArgGlyGlyLysGlyGlyGluSerValArgAlaGluGlySerPro-85 92-LeuAspGlyGlyLysGlyThrValArgGlyGlnAla-103 121-AlaLysValGlnArgGlyGlyAspValAlaGlu-131 148-GlySerThrLysSerGlyAlaLysSerAlaSerLysThrGlyArg-162 171-SerThrGlnLysThrGlu-176 g215 AMPHI Regions - AMPHI 21-SerLeuSerAlaTrpLeuGlyArgIle-29 67-SerAlaLysGlyAlaLysGlnPhe-74 Antigenic Index - Jameson-Wolf 3 -ValArgTrpArgTyrGly-8 28-ArgIleSerGluValGluIleGluGluValArgLeuAsnProAspGluProGlnTyrThrMetAspGlyLeuA spGlyArgArgPheAspGluGlnGlyTyrLeuLys-63 65-HisLeuSerAlaLysGlyAlaLysGlnPheProGluAsnSerAspIleHisPheAspSerProHisLeu-87 99-ValGlySerAspGluAlaValTyrHisThrGluAsnLysGlnValLeuPhe-115 123-LysThrAlaAspGlyArgArgGlnAlaGlyLysValGluThrGluLysLeuHisValAspThrGluSerGln TyrAlaGlnThrAspThrProVal-154 160-AlaSerHisGlyGlnAlaGlyGly-167 170-TyrAsnHisLysThrGly-175 179-PheSerSerLysValLys-184 187-IleTyrAspThrLysAspMet-193 Hydrophilic Regions - Hopp-Woods 29-IleSerGluValGluIleGluGluValArgLeuAsnProAspGluProGlnTyr-46 49-AspGlyLeuAspGlyArgArgPheAspGlu-58 65-HisLeuSerAlaLysGlyAlaLysGlnPheProGluAsnSerAspIleHisPhe-82 99-ValGlySerAspGluAlaValTyr-106 108-ThrGluAsnLysGlnValLeu-114 123-LysThrAlaAspGlyArgArgGlnAlaGlyLysValGluThrGluLysLeuHisValAspThrGluSerGln TyrAla-148 187-IleTyrAspThrLysAspMet-193 g216-2 AMPHI Regions - AMPHI 19-AlaGluGlyLeuArgGluIleAlaAlaGluLeu-29 60-ArgLysMetAlaAla-64 165-LeuGlyAspAlaLeuAlaVal-171 201-ValAlaAspIleMetHis-206 251-GlyAspLeuArgArgLeuPheGlnGluCysAspAsnPheThrGlyLeuSerIle-268 272-MetHisThrHisProLysThrIleSerAla-281 290-LysValMetGlnAlaAsn-295 Antigenic Index - Jameson-Wolf l-MetAlaGluAsnGluLysTyrLeuAspTrpAlaArg-12 14-ValLeuHisThrGluAlaGluGlyLeuArgGluIleAlaAlaGluLeuAspGlu-31 43-CysLysGlyArgVal-47 51-GlyMetGlyLysSerGlyHisIleGlyArgLysMetAla-63 80-GluAlaAlaHisGlyAspLeu-86 90-ValAspAsnAspVal-94 99-SerAsnSerGlyGluSerAspGluIle-107 113-AlaLeuLysArgLysAspIle-119 125-ThrAlaArgProAspSerThrMetAlaArgHisAlaAsp-137 144-ValSerGlnGluAlaCysProLeu-151 177-ArgAlaPheThrProAspAspPheAla-185 190-AlaGlySerLeuGlyLys-195 203-AspIleMetHisLysGlyGlyGlyLeuProAla-213 227-MetSerGluLysGlyLeu-232 238-ThrAspGlyGlnGlyCysLeu-244 248-PheThrAspGlyAspLeuArgArgLeuPheGlnGluCysAspAsnPheThr-264 275-HisProLysThrIleSerAlaGluArgLeuAlaThrGluAlaLeuLys-290 Hydrophilic Regions - Hopp-Woods l-MetAlaGluAsnGluLysTyrLeuAspTrpAlaArg-12 14-ValLeuHisThrGluAlaGluGlyLeuArgGluIleAlaAlaGluLeuAspGlu-31 43-CysLysGlyArgVal-47 56-GlyHisIleGlyArgLysMetAla-63 100-AsnSerGlyGluSerAspGluIle-107 113-AlaLeuLysArgLysAspIle-119 126-AlaArgProAspSerThrMetAlaArgHisAlaAsp-137 144-ValSerGlnGluAla-148 177-ArgAlaPheThrProAspAsp-183 227-MetSerGluLysGlyLeu-232 251-GlyAspLeuArgArgLeuPheGlnGluCysAspAsn-262 277-LysThrIleSerAlaGluArgLeuAlaThrGluAlaLeuLys-290 g218 AMPHI Regions - AMPHI 9-AlaLysValValAsnThrMet-15 23-HisThrMetAspGluIleHisGly-30 78-AlaArgSerTrpTrpArgAsnLeuHisGlyAlaPheGlyThrTrpValSerLeuIleLeu-97 lll-TrpGlyGlyLysPheValGlnAlaTrpAsnGlnPhePro-123 176-ThrGluProAsnAsnIle-181 187-PheArgAlaGlyAsnArgPheGlnArgAlaLeuSerVal-199 Antigenic Index - Jameson-Wolf 14-ThrMetProArgAsnGlnGlyTrp-21 26-AspGluIleHisGly-30 62-AlaLysGlnArgGlyIleLys-68 71-LeuLeuProProLysSerArgAlaArgSerTrpTrp-82 86-HisGlyAlaPheGly-90 123-ProAlaGlyLysTrpGlyValGluProAsnProVal-134 143-ValLeuAsnAspGlyLysValLysGlu-151 167-ThrValGlyGluAsnGlyIleAsnProThrGluProAsnAsnIleGlyAsnArgArgProPheArgAlaGly AsnArgPheGlnArg-195 201-PheAlaGlnArgArgGlyArgGlyMetAspPhe-211 Hydrophilic Regions - Hopp-Woods 26-AspGluIleHisGly-30 64-GlnArgGlyIleLys-68 74-ProLysSerArgAla-78 143-ValLeuAsnAspGlyLysValLysGlu-151 171-AsnGlyIleAsnProThrGluProAsnAsnIleGlyAsnArgArgProPheArgAlaGlyAsnArgPheGln Arg-195 201-PheAlaGlnArgArgGlyArgGlyMetAsp-210 g225-l AMPHI Regions - AMPHI 23-LeuAlaAspGluLeuThrAsn-29 37-IleLeuArgGlnPhe-41 92-AspLysLeuIleGlySerAlaMetArg-100 122-PheMetGlnHisIlePheLys-128 188-ThrGlyLysAsnIle-192 Antigenic Index - Jameson-Wolf 22-AlaLeuAlaAspGluLeuThr-28 32-SerSerArgGluGlnIleLeu-38 41-PheAlaGluAspGluGlnProVal-48 50-ProValAsnArgAlaProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-66 79-ArgValAsnArgAlaXxxAlaArgArgAlaGlyAsnAlaAspLysLeuIle-95 115-ThrGlyPheAspCysSerGly-121 135-LeuProArgThrSerAlaGluGlnAlaArgMet-145 147-AlaProValAlaArgSerGluLeuGlnProGlyAsp-158 165-LeuGlyGlySerArgIleSer-171 184-HisAlaProArgThrGlyLysAsnIleGlu-193 196-SerLeuSerHisLysTyrTrpSerGlyLys-205 210-ArgArgValLysLysAsnAspProSerArgPhe-220 Hydrophilic Regions - Hopp-Woods 22-AlaLeuAlaAspGluLeuThr-28 32-SerSerArgGluGlnIleLeu-38 41-PheAlaGluAspGluGlnPro-47 53-ArgAlaProAlaArgArgAlaGlyAsnAlaAspGluLeuIle-66 79-ArgValAsnArgAlaXxxAlaArgArgAlaGlyAsnAlaAspLysLeuIle-95 137-ArgThrSerAlaGluGlnAlaArgMet-145 149-ValAlaArgSerGluLeuGlnPro-156 187-ArgThrGlyLysAsnIleGlu-193 210-ArgArgValLysLysAsnAspProSerArg-219 g226 AMPHI Regions - AMPHI 44-LeuIleAlaTyrLeuLys-49 98-GlnLeuAlaGlySerValThrGlyIleValThr-108 142-ThrLeuTyrAlaArgValLeuProPro-150 165-ThrLeuArgArgPhe-169 174-LysLysLeuArgProPheLysProLeuLeuProVal-185 Antigenic Index - Jameson-Wolf 3-GluIleLeuArgGlnProSer-9 25-ValArgThrArgThrGlyAsnIle-32 67-PheArgLeuLysPro-71 81-TyrGlnAsnArgArgLysIle-87 117-GlyProAspThrGlnPhe-122 124-PheProProArgLeu-128 155-ProProLeuLeuProArgLeuGlyProHisThrLeuArgArg-168 171-IleLeuProLysLysLeuArgProPheLys-180 Hydrophilic Regions - Hopp-Woods 25-Va1ArgThrArgThr-29 82-GlnAsnArgArgLysIle-87 173-ProLysLysLeuArgPro-178 g227 AMPHI Regions - AMPHI 36-GlyValLeuPheAlaLeuLeuGlnAla-44 51-TrpLeuGlnGlnLeuThrAspAlaLeu-59 74-ValIleSerTyrLeuAspLeuIleAlaAspAspTrpPheSer-87 g230-l AMPHI Regions - AMPHI 6-GluLysTyrArgThr-10 49-GluHisSerIleAsnAsn-54 56-MetGlnAsnGluGln-60 69-AspAlaValPheGlnSerLeuLeuGln-77 81-LeuLysGlnGlyAlaLys-86 96-GlnIleLysGlnMetIle-101 115-SerHisAlaLeuLeuSer-120 133-PheValGluGluIleArgAspGlnPhe-141 144-GlnAsnLeuValSerLeu-149 161-AlaGluGlnLeuIleArgLeuThrGlnValAsnArgThrIleArg-175 184-PheIleAlaGlnVal-188 194-AspLeuGlnLysPheTyrAsn-200 234-GluValLysAsnAlaPheGluGluArgValAlaArgLeu-246 272-ValAlaAspPheAsnLys-277 284-AspAspAlaPheAsnHisProSerSerLeuAlaGluAla-296 319-SerGlyMetProGluAsnLeuIleAsnAlaVal-329 398-LeuAsnGlyGlyLys-402 426-GluAlaTyrAlaGluLeu-431 461-ThrProProGluAspIleAlaAla-468 488-LeuLeuIleArgTyrPheAsn-494 Antigenic Index - Jameson-Wolf 4-SerIleGluLysTyrArgThrProAla-12 32-SerHisProGlyAlaAsp-37 42-ValGlyAspGluLysIleSerGluHisSerIle-52 56-MetGlnAsnGluGlnAlaAspGlyGlySerProTrpArg-68 80-TyrLeuLysGlnGlyAla-85 92-ValSerSerGluGlnIleLys-98 lOl-IleValAspAspProAsnPheHisAspAlaAsnGlyLysPhe-114 123-LeuSerGlnArgHisMetSerGluAspGlnPheValGluGluIleArgAsp-139 169-GlnValAsnArgThrIleArgSerHisThrPheAsnProAspGluPhe-184 189-LysAlaSerGluAlaAspLeu-195 199-TyrAsnAlaAsnLysLysAspTyrLeu-207 223-AspPheAlaAspLysGlnThrValSerGluThrGluValLysAsnAlaPheGluGluArgValAlaArg-24 5 247-ProAlaHisGluAlaLysProSerPheGluGlnGluLysAlaAlaValGluAsnGluLeuLysMetLysLys AlaValAlaAspPheAsnLysAlaLysGluLysLeuGlyAspAspAlaPheAsnHisProSerSerLeuAlaGluA laAlaLysAsnSerGlyLeuLysValGluThrGlnGluThrTrpLeuSerArgGlnAspAlaGlnMetSerGlyMe tProGluAsn-324 330-PheSerAspAspValLeuLysLysLysHisAsnSerGlu-342 355-ArgAlaLysGluValArgGluGluLysAsnLeuLeu-366 368-GluGluAlaLysAspAlaValArg-375 377-AlaTyrIleArgThrGluAlaAlaLysLeuAlaGluAsnLysAlaLysGluValLeu-395 399-AsnGlyGlyLysAlaValAsp-405 417-GlnGlnAlaArgGlnSerMetProProGluAlaTyr-428 432-LeuLysAlaLysProAlaAsnGlyLysProAla-442 459-AlaValThrProProGluAspIleAla-467 476-AlaLeuAlaGlnGlnGlnSerAlaAsnThrPhe-486 493-PheAsnGlyLysIleLysGlnThrLysGlyAlaGlnSerValAspAsnGlyAspGlyGln-512 Hydrophilic Regions - Hopp-Woods 6-GluLysTyrArgThr-10 42-ValGlyAspGluLysIleSerGlu-49 56-MetGlnAsnGluGlnAlaAspGly-63 92-ValSerSerGluGlnIleLys-98 101-IleValAspAspProAsnPhe-107 110-AlaAsnGlyLysPhe-114 126-ArgHisMetSerGluAspGlnPheValGluGluIleArgAsp-139 189-LysAlaSerGluAlaAspLeu-195 200-AsnAlaAsnLysLysAspTyrLeu-207 223-AspPheAlaAspLysGlnThrValSerGluThrGluValLysAsnAlaPheGluGluArgValAlaArg-24 5 247-ProAlaHisGluAlaLysProSerPheGluGlnGluLysAlaAlaValGluAsnGluLeuLysMetLysLys AlaValAlaAspPheAsnLysAlaLysGluLysLeuGlyAspAspAlaPheAsn-288 292-SerLeuAlaGluAlaAlaLysAsnSerGlyLeuLysValGluThrGlnGlu-308 310-TrpLeuSerArgGlnAspAlaGlnMet-318 333-AspValLeuLysLysLysHisAsnSer-341 355-ArgAlaLysGluValArgGluGluLysAsnLeuLeu-366 368-GluGluAlaLysAspAlaValArg-375 377-AlaTyrIleArgThrGluAlaAlaLysLeuAlaGluAsnLysAlaLysGluValLeu-395 417-GlnGlnAlaArgGlnSerMetPro-424 432-LeuLysAlaLysProAlaAsnGly-439 461-ThrProProGluAspIleAla-467 496-LysIleLysGlnThrLysGlyAlaGlnSerValAspAsnGlyAspGlyGln-512 g231-l AMPHI Regions - AMPHI 7-IleAsnArgProTyrGlnLysProAlaGluLeu-17 98-ArgIlePheSerPheProGln-104 169-TyrAsnGluPheArgThrLeuArgArg-177 209-AlaValAspAspValLysGlyIleAlaVal-218 Antigenic Index - Jameson-Wolf l-MetSerLysArgLysSerIleAsnArgProTyrGlnLysProAlaGlu-16 18-ProProLeuGlnAsnAsnProProPheTyrArgLysAsnArgArgLeuAsn-34 39-AlaAspGlyGlyCysAlaSerProGlnLysCysArgAlaArgGlyPheGln-55 90-ProAlaValArgProArgArgLeuArg-98 135-MetProArgArgProVal-140 167-HisThrTyrAsnGluPheArgThrLeuArgArgArgAlaGlnVal-181 196-ValAspIleArgHisProAsn-202 209-AlaValAspAspValLysGly-215 Hydrophilic Regions - Hopp-Woods l-MetSerLysArgLysSerIleAsn-8 10-ProTyrGlnLysProAlaGlu-16 26-PheTyrArgLysAsnArgArg-32 45-SerProGlnLysCysArgAlaArgGly-53 92-ValArgProArgArgLeuArg-98 136-ProArgArgProVal-140 173-ArgThrLeuArgArgArgAlaGlnVal-181 196-ValAspIleArgHis-200 209-AlaValAspAspValLysGly-215 g232 AMPHI Regions - AMPHI 14-AlaIleLeuPheGly-18 21-LeuGlyThrAlaVal-25 68-ValArgGlyThrLysSerLeuLeuArgGluThrVal-79 105-LeuProThrPheThrGln-110 151-ValThrValGlyAlaLeuGlySerThrValCys-161 173-ArgPheGluGlyLeuAsn-178 194-AlaValMetThrLeuIleGlyPhePheGlyGlyPhePheSerValProLeuTyrThrTrpLeu-214 Antigenic Index - Jameson-Wolf 54-ValProAlaLysAlaAlaAspThrGlnIle-63 69-ArgGlyThrLysSerLeuLeuArgGluThrValArgHisAsnProVal-84 112-HisLeuGlyGlyAsnAspAsnVal-119 140-LysPheGlyArgGluArgLeu-146 170-HisGlyHisArgPheGluGly-176 217-AlaSerSerGluThrPheArgAlaArgAla-226 274-IleLysArgGluArgArgPheLeu-281 285-AlaIleArgLysLysPro-290 Hydrophilic Regions - Hopp-Woods 55-ProAlaLysAlaAlaAspThrGlnIle-63 69-ArgGlyThrLysSerLeuLeuArgGluThrValArg-80 140-LysPheGlyArgGluArgLeu-146 172-HisArgPheGluGly-176 220-GluThrPheArgAlaArgAla-226 274-IleLysArgGluArgArgPheLeu-281 285-AlaIleArgLysLysPro-290 g233 AMPHI Regions - AMPHI 36-GluHisValLeuGly-40 61-PheAlaAspLysValGlnThr-67 71-GlnValArgValTrpLysAsn-77 88-AsnGlyValAlaLysLeuLeuGluThr-96 119-AlaLeuAlaArgLeuIleGluGlnAlaGlyAsnAla-130 138-ValProValAlaAspThrLeuLysArgAlaGluSer-149 182-GluAsnLeuGlyGlyIleThrAsp-189 Antigenic Index - Jameson-Wolf l-MetLysArgLysAsnIle-6 17-ArgPheGlyAlaAspLysProLysGlnTyrValGluIleGlySerLysThrValLeu-35 43-GluArgHisGluAlaValAsp-49 56-SerProGluAspThrPheAlaAspLysValGln-66 75-TrpLysAsnGlyGlyGlnThrArgAlaGluThrValArgAsnGlyVal-90 100-AlaGluThrAspAsn-104 109-AspAlaAlaArgCys-113 115-LeuProSerGluAlaLeu-120 123-LeuIleGluGlnAlaGlyAsnAlaAlaGluGlyGly-134 142-AspThrLeuLysArgAlaGluSerGlyGln-151 155-ThrValAspArgSerGlyLeu-161 183-AsnLeuGlyGlyIleThrAspGluAlaSerAlaValGluLysLeuGlyVal-199 206-GlyAspAlaArgAsnLeuLysLeuThrGlnProGlnAspAlaTyr-220 Hydrophilic Regions - Hopp-Woods 1-MetLysArgLysAsnl1e-6 18-PheGlyAlaAspLysProLysGlnTyrVal-27 43 -GluArgHisGluAlaValAsp-49 56-SerProGluAspThrPheAlaAspLysValGln-66 79-GlyGlnThrArgAlaGluThrValArg-87 100-AlaGluThrAspAsn-104 127-AlaGlyAsnAlaAlaGlu-132 142-AspThrLeuLysArgAlaGluSerGlyGln-151 187-IleThrAspGluAlaSerAlaValGluLysLeuGlyVal-199 206-GlyAspAlaArgAsnLeuLys-212 g234 AMPHI Regions - AMPHI 26-ArgSerLeuGluValAlaLysValAla-34 68-AspArgLeuGlySerGln-73 83-GlnGlnThrAsnArgPheAsnValLeuAsnArgThrAsn-95 121-GlyAspValThrGluPhe-126 205-GluAlaValAspAsnLeuValGlnAlaValAspAsn-216 Antigenic Index - Jameson-Wolf 21-AlaThrGluSerSerArgSerLeuGluValAlaLys-32 51-ThrPheAspAsnArgSerSerPhe-58 62-IlePheSerAspSerGluAspArgLeuGlySerGlnAla-74 83-GlnGlnThrAsnArgPheAsnValLeuAsnArgThrAsn-95 99-LeuLysGlnGluSerGlyIleSerGlyLysAlaGlnAsnLeuLysGlyAlaAspTyr-117 121-GlyAspValThrGluPheGlyArgArgAspValGlyAsp-133 140-LeuGlyArgGlyLysSerGlnIle-147 169-GlnGlyAlaGlyGlu-173 175-AlaLeuSerAsnArgGluIle-181 185-GlyGlyThrSerGlyTyrAspAlaThrLeuAsnGlyLysValLeu-199 214-ValAspAsnGlyAlaTrpGlnSerAsnArg-223 Hydrophilic Regions - Hopp-Woods 21-AlaThrGluSerSerArgSerLeuGluValAlaLys-32 52-PheAspAsnArgSerSerPhe-58 62-IlePheSerAspSerGluAspArgLeuGlySerGlnAla-74 99-LeuLysGlnGluSerGlyIleSerGlyLysAlaGlnAsnLeuLysGly-114 122-AspValThrGluPheGlyArgArgAspValGlyAsp-133 141-GlyArgGlyLysΞer-145 176-LeuSerAsnArgGluIle-181 g235 AMPHI Regions - AMPHI 8-LeuAlaAlaValLeuAlaLeu-14 18-GlnValArgLysAlaProAsp-24 88-AsnAlaAlaAspIle-92 95-ValArgProGluLysLeuHisGlnIlePhe-104 120-SerTyrGlnIleLeuAspSerValThrThr-129 165-GlyAlaLeuValGlyAlaValValAsnGlnIleAlaAsnSerLeuThr-180 187-SerLysThrAlaAlaTyrAsnLeuLeu-195 Antigenic Index - Jameson-Wolf 17-CysGlnValArgLysAlaProAspLeuAspTyrThrSerPheLysGluSerLysProAla-36 43-ProLeuAsnGluSerProAspValAsnGlyThr-53 79-GluThrPheLysGluAsnGlyLeu-86 93-HisAlaValArgProGluLysLeu-100 131-SerAlaLysAlaArgLeuValAspSerArgAsnGlyLysGluLeuTrpSerGlySerAlaSerIleArgGlu GlySerAsnAsnSerAsnSer-161 178-SerLeuThrAspArgGlyTyrGlnValSerLysThrAla-190 197-ProTyrSerArgAsnGlyIleLeuLysGlyProArgPheValGluGluGlnProLys-215 Hydrophilic Regions - Hopp-Woods 18-GlnValArgLysAlaProAspLeuAsp-26 29-SerPheLysGluSerLysPro-35 44-LeuAsnGluSerProAspVal-50 79-GluThrPheLysGluAsnGlyLeu-86 93-HisAlaValArgProGluLysLeu-100 131-SerAlaLysAlaArgLeuValAspSerArgAsnGlyLysGluLeuTrp-146 150-AlaSerIleArgGluGlySerAsnAsnSer-159 179-LeuThrAspArgGlyTyrGln-185 207-ProArgPheValGluGluGlnProLys-215 g236 AMPHI Regions - AMPHI 10-HeLeuArgThrAlaPhe-15 107-PheAlaArgPheAlaAspCysArgProPhe-116 146-AspAspValProArgPhePheAlaGlyGlu-155 168-ArgAspValValGlnGlyGlyLeu-175 213-GlyGluValGluGlyIleAlaArgIleValThrAlaCysGlnThrLeuLeuGlnProProArgGlnTyrGln -236 245-IleArgLeuLeuHisGlyIlePheAsnArgIleLysValAla-258 275-PheGlyAsnAlaPheGluAspPhe-282 316-ValAlaAspGlyPheArgHisPheAlaAla-325 Antigenic Index - Jameson-Wolf 43-PheGlyGlyAsnGlyLysPheIleThr-51 58-ArgHisGlnGlnGlyLysAla-64 77-PhePheArgArgGlyAsnPheGlyPheArgLeuGlnGlyArgThrAspSerPhe-94 98-GlnArgLeuAspSerGlyGlyTyr-105 lll-AlaAspCysArgProPhe-116 126-ValAspGlyArgGluLeuValProSerMetGluGluAspAla-139 145-AlaAspAspValPro-149 152-PheAlaGlyGluAlaGlnAsnArgCysAsnGlnGluAsnGlnAlaAlaArgAspValValGlnGlyGlyLeu -175 195-ValGluValGluArgAlaGlnValPheArgAlaGluArgAsnAsnValPhe-211 213-GlyGluValGluGlyIleAla-219 230-GlnProProArgGlnTyrGln-236 261-GlyLysGlnGluAlaGlnGly-267 292-IleGlyGlyCysArgProGlnAlaGlnAspValArgAla-304 310-PheLeuArgArgAspAspValAlaAspGly-319 341-CysAlaSerHisGly-345 Hydrophilic Regions - Hopp-Woods 87-LeuGlnGlyArgThrAspSer-93 98-GlnArgLeuAspSer-102 127-AspGlyArgGluLeuValProSerMetGluGluAspAla-139 145-AlaAspAspValPro-149 156-AlaGlnAsnArgCysAsnGlnGluAsnGlnAlaAlaArgAspValVal-171 195-ValGluValGluArgAlaGlnValPheArgAlaGluArgAsnAsn-209 213-GlyGluValGluGlyIleAla-219 261-GlyLysGlnGluAlaGlnGly-267 295-CysArgProGlnAlaGlnAspValArgAla-304 310-PheLeuArgArgAspAspValAlaAspGly-319 g238 AMPHI Regions - AMPHI 103-ValHisSerProPheAsp-108 115-ThrSerAspPheSerGlyGlyVal-122 129-TyrGlnLeuHisArgThrGlySer-136 140-ProAlaAspGlyTyrAspGlyProGlnGlyGlyGlyTyrProGluProGlnGlyAlaArgAspIleTyrSer Tyr-164 221-AsnArgMetAspAspIleArgGlyIleValGlnGlyAlaValAsnProPheLeuThrGlyPheGlnGlyVal -244 246-IleGlyAlaIleThrAspSerAlaValSerProValThrAspThrAlaAlaGlnGlnThrLeuGlnGlyIle AsnAspLeuGlyAsn-274 298-IleAsnSerAlaArgGlnTrpAlaAspAla-307 342-AspTrpValLysAsn-346 351-LysProAlaAlaArgHisMetGlnThrVal-360 367-GlyAsnArgProProLysSerIleThrSer-376 383-AlaThrTyrProLysLeuValAsnGlnLeuAsnGluGlnAsnLeu-397 426-GluGluAlaAspArgLeuGlyLysIleTrpVal-436 454-ThrArgGlnTyrArg-458 Antigenic Index - Jameson-Wolf 25-HisAlaAsnGlyLeuAspAlaArgLeuArgAspAspMetGlnAlaLysHisTyrGluProGlyGlyLys-47 53-AsnAlaArgGlySerValLysAsnArgVal-62 80-ThrHisGluArgThrGlyPheGluGly-88 96-PheSerGlyHisGlyHisGluVal-103 105-SerProPheAspAsnHisAspSerLysSerThrSerAspPheSerGlyGlyValAspGlyGly-125 131-LeuHisArgThrGlySerGluIleHisProAlaAspGlyTyrAspGlyProGlnGlyGlyGlyTyrProGlu ProGlnGlyAlaArgAspIleTyr-162 166-IleLysGlyThrSerThrLysThrLysIle-175 182-ProPheSerAspArgTrpLeuLysGluAsnAlaGlyAla-194 200-SerArgAlaAspGluAlaGly-206 210-TrpGluAsnAspProAspLysAsnTrpArgAlaAsnArgMetAspAspIleArgGlyIle-229 268-GlyIleAsnAspLeuGlyAsnLeuSerProGluAla-279 292-PheAlaValLysAspGlyIleAsnSerAlaArgGlnTrpAlaAspAlaHisProAsnIle-311 328-ValTrpArgGlyLysLysValGluLeuAsnProThrLysTrpAspTrpValLysAsnThrGlyTyrLysLys ProAlaAlaArg-355 358-GlnThrValAspGlyGluMetAlaGlyGlyAsnArgProProLysSerIleThrSerGluGlyLysAlaAsn -381 391-GlnLeuAsnGluGlnAsnLeu-397 401-AlaAlaGlnAspProArgLeu-407 411-IleHisGluGlyLysLysAsnPhePro-419 423-AlaThrTyrGluGluAlaAspArgLeuGly-432 438-GluGlyAlaArgGlnThrSerGlyGlyGlyTrpLeuSerArgAspGlyThrArgGlnTyrArgProProThr GluLysLysSerGln-466 480-Thr11eAspSerAsnGluLysArgAsnLysIleLysAsnGly-493 Hydrophilic Regions - Hopp-Woods 29-LeuAspAlaArgLeuArgAspAspMetGlnAlaLysHisTyrGluProGlyGly-46 54-AlaArgGlySerValLysAsnArgVal-62 80-ThrHisGluArgThrGlyPhe-86 107-PheAspAsnHisAspSerLysSerThrSerAspPhe-118 133-ArgThrGlySerGluIleHisPro-140 142-AspGlyTyrAspGlyProGln-148 151-GlyTyrProGluProGlnGlyAlaArgAsp-160 168-GlyThrSerThrLysThrLysIle-175 186-ArgTrpLeuLysGluAsnAlaGly-193 200-SerArgAlaAspGluAlaGly-206 212-AsnAspProAspLysAsnTrpArgAlaAsnArgMetAspAspIleArgGly-228 296-AspGlyIleAsnSer-300 329-TrpArgGlyLysLysValGluLeuAsnProThr-339 347-ThrGlyTyrLysLysProAlaAlaArg-355 360-ValAspGlyGluMetAlaGlyGlyAsnArgProProLysSerIleThrSerGluGlyLysAlaAsn-381 392-LeuAsnGluGlnAsnLeu-397 401-AlaAlaGlnAspProArgLeu-407 412-HisGluGlyLysLysAsnPhe-418 424-ThrTyrGluGluAlaAspArgLeuGly-432 438-GluGlyAlaArgGlnThrSer-444 449-LeuSerArgAspGlyThrArgGlnTyrArgProProThrGluLysLysSerGln-466 482-AspSerAsnGluLysArgAsnLysIleLysAsn-492 g239 AMPHI Regions - AMPHI 49-PheArgLeuValGlnSerCys-55 72-AsnAlaHisArgLysGln-77 123-ProGlyPheAsnAlaLeuProThrIlePhe-132 154-GluTyrPheLeuThr-158 165-SerSerAsnGluTrp-169 221-PheCysAlaThrIleCysAlaSerLeuArg-230 Antigenic Index - Jameson-Wolf 6-GlyIleAlaArgAsnArgArgMetGlu-14 19-CysArgArgProAspArgPheVal-26 28-ArgGlnThrArgLeuLeu-33 53-GlnSerCysGluValGluPro-59 66-HisAsnGlyLysSerGlyAsnAlaHisArgLysGlnGlnLysGluIleArg-82 84-ValHisCysArgSerAspVal-90 100-ProAlaValArgSerAlaThrArgLysThrAla-110 132-PheArgGlyGlySerGlyLysSerAlaSer-141 147-LeuGlyArgGlySerCysCysGluTyr-155 164-ArgSerSerAsnGluTrpLys-170 173-ThrAlaLysArgProProSerPheArgArgHisMetThrCysGlyAsnThrAlaProThrSerSerSerSer ArgLeuIleLys-200 209-ValAlaGlySerCysProArgSerArgValArgThr-220 248-TrpArgLeuAsnArgSerSerPro-255 Hydrophilic Regions - Hopp-Woods 6-GlyIleAlaArgAsnArgArgMetGlu-14 20-ArgArgProAspArgPheVal-26 67-AsnGlyLysSerGlyAsnAlaHisArgLysGlnGlnLysGluIleArg-82 102-ValArgSerAlaThrArgLysThrAla-110 135-GlySerGlyLysSerAlaSer-141 165-SerSerAsnGluTrpLys-170 173-ThrAlaLysArgProProSerPheArgArgHisMet-184 193-SerSerSerSerArgLeuIleLys-200 211-GlySerCysProArgSerArgValArgThr-220 251-AsnArgSerSerPro-255 g240 AMPHI Regions - AMPHI 19-AlaAspValGlyArgPheLeuHis-26 64-IleGlnCysLeuArgAsnHis-70 88-AlaProLeuPheAla-92 108-GlnGlyGluAspPheProArgAlaGlyIleGlnAsnHis-120 164-ValGlnAlaValHisAsn-169 178-AsnPheArgAlaValPheAlaIle-185 189-PheLysArgLysPheGln-194 Antigenic Index - Jameson-Wolf 10-AlaGluThrArgArgGlnPheAla-17 41-AlaHisGlyArgArgSerAspPheIleArg-50 68-ArgAsnHisGluArgPheAspCysArgThrArgPheAsp-80 102-ValGlyGlyArgIleGlyGlnGlyGluAspPheProArgAlaGlyIleGlnAsnHisHisArgSerGly-12 4 140-GlnGlyLeuAsnProLeuIleGluGlyLysAspAspVal-152 189-PheLysArgLysPhe-193 202-AsnIleGlyLysSerAspAspValCysLys-211 Hydrophilic Regions - Hopp-Woods 10-AlaGluThrArgArgGlnPheAla-17 42-HisGlyArgArgSerAspPheIleArg-50 68-ArgAsnHisGluArgPheAspCysArgThrArgPheAsp-80 106-IleGlyGlnGlyGluAspPheProArg-114 146-IleGluGlyLysAspAspVal-152 189-PheLysArgLysPhe-193 204-GlyLysSerAspAspValCysLys-211 g241-l AMPHI Regions - AMPHI 6-ThrArgAlaAlaAsnProPro-12 35-ThrHisThrProHisGluProAlaSerSer-44 109-PheLeuIleGlyCysIleAlaHisAlaPheAsnArgΞerPheLys-123 126-PheHisAlaCysGlnArgMetValAlaVal-135 195-HisPheAspArgIleAlaGlyIleLeuThrValln-206 228-GlyPheIleGlnLysLeuIleValGlyIleIleHis-239 Antigenic Index - Jameson-Wolf l-MetProThrArgProThrArgAlaAlaAsnProProThrPro-14 22-TyrCysProArgProProTyrArgProProSerValGlnThrHisThrProHisGluProAlaSerSerThrC ysAlaAlaLysSerAlaAsnArgArgGluAsnSerHisAsnAlaGlnPro-62 68-ProSerAsnLysMetProSerGluThrGluGlnThrLeuPheArgArgHisGlnIleProProSerCysArgG lnSer-93 119-AsnArgSerPheLysAla-124 147-ThrIleAspAspAsnIleAla-153 161-LysHisHisThrAspLeuAspPheAsnArgGluArgAlaArgIlePheAsnThrAspGlnLeu-181 188-ArgIleValGlyArgLysArgHisPheAspArg-198 209-PheHisGlnArgGluAsnAla-215 244-ArgAsnHisGlyIlePheCysAsnSerHis-253 255-CysProPheArgAsnSerArgLeuIle-263 Hydrophilic Regions - Hopp-Woods 1-MetProThrArgProThrArgAlaAlaAsn-lO 37-ThrProHisGluProAlaSer-43 46-CysAlaAlaLysSerAlaAsnArgArgGluAsnSerHis-58 70-AsnLysMetProSerGluThrGluGlnThrLeuPheArg-82 120-ArgSerPheLysAla-124 161-LysHisHisThrAspLeuAspPheAsnArgGluArgAlaArgIlePheAsn-177 188-ArgIleValGlyArgLysArgHisPheAspArg-198 209-PheHisGlnArgGluAsnAla-215 g242 AMPHI Regions - AMPHI 25-ValAlaAlaGlnPheValAspPheValGluGln-35 46-HisIleLeuGlnAsn-50 100-AlaAspGlnThrGln-104 122-AsnProPhePheAspPhePheGlnAlaValVal-132 137-HisGlnSerGlyPheGlyAspValPhe-145 191-PheGlyHisThrArg-195 197-PheAspAlaCysLeu-201 262-HisProPheAlaAspPheGlyAsnLeuGlnAsnLeuLeuAlaLeu-276 Antigenic Index - Jameson-Wolf 14-PheLysGlnArgAlaGlyGlyIleAla-22 33-ValGluGlnGluGlnArgValSer-40 54-HisArgAlaAspIleGlyThrAlaValProAla-64 73-AlaGlnGlyHisThrAspIlePheProProArgCysPheGlyAspGlyPheAlaGlnArgGlyPheAlaHisA laArgArgAlaAspGlnThrGlnAsnArgThrPhe-108 137-HisGlnSerGlyPhe-141 152-LeuProArgGlnSerGluGlnGlyVal-160 164-AlaTyrAspGlyGlyPheGlyArgHisArgArgHisHis-176 283-MetArgCysAspArgIleGly-289 Hydrophilic Regions - Hopp-Woods 14-PheLysGlnArgAlaGlyGlyIle-21 33-ValGluGlnGluGlnArgVal-39 54-HisArgAlaAspIle-58 95-AlaHisAlaArgArgAlaAspGlnThrGlnAsnArgThrPhe-108 154-ArgGlnSerGluGlnGlyVal-160 168-GlyPheGlyArgHisArgArgHisHis-176 283-MetArgCysAspArgIleGly-289 g243 AMPHI Regions - AMPHI 35-MetThrArgLeuAlaArgLysAlaValGlnArgLeuThrAlaSerHisIleGlnArgPheLeu-55 80-AspSerSerArgIleThrSerThrIle-88 Antigenic Index - Jameson-Wolf 30-ProSerAsnAlaPro-34 37-ArgLeuAlaArgLysAlaValGln-44 55-LeuThrGluSerLysThrGlyAlaAsnArgSerSerSerSerCysLysPro-71 77-SerAlaSerAspSerSerArgIle-84 102-SerThrThrGlyAlaValThrLysSer-llO Hydrophilic Regions - Hopp-Woods 37-ArgLeuAlaArgLysAlaValGln-44 55-LeuThrGluSerLysThrGlyAlaAsnArgSerSerSerSerCysLys-70 78-AlaSerAspSerSerArgIle-84 g244-l AMPHI Regions - AMPHI 13-IleAlaAlaLeuLeuArg-18 24-AsnAlaLeuGlnGluIleAsnGlnIleIleProGlnThr-36 76-ArgLeuHisArgLeu-80 98-LeuArgGlyIleLysArgLeuLeuGlnLeuIleGlnSerHisLeuHisThrHis-115 150-ArgIleGlyAsnPhe-154 206-CysLeuAspGlyPheHisArgLeuHis-214 217-AsnArgPhePheThr-221 249-IleArgThrPheSerArgAsnPheLysGln-258 Antigenic Index - Jameson-Wolf l-MetProProGluAlaArgProAlaGlySerAspGly-12 20-ValTyrThrGlnAsnAla-25 35-GlnThrProSerGly-39 43-CysHisArgAsnHisSerArgAlaGlnHis-52 81-MetAspIleArgIle-85 91-PheArgl1eAspPheLeuAsp-97 99-ArgGlyIleLysArg-103 125-IleGlnLysArgHis-129 134-LeuAspArgGlnHisPheHisGlyLysLeuLeuSerGlyGluLeuValArg-150 178-PheGlnLeuGlyAsnProArgLeu-185 191-ArgLeuGlyGlySer-195 234-LeuLysThrAsnTrpLysSerLysSerGlyTyrTyrProSerLysIleArgThrPheSerArgAsnPheLys GlnArgGlnGluIleSerHisProProProAsnThrLeuProGlnLysProTyrLysArg-277 Hydrophilic Regions - Hopp-Woods l-Me ProProGluAlaArgProAlaGlySerAspGly-12 45-ArgAsnHisSerArgAlaGlnHis-52 81-MetAspIleArgIle-85 91-PheArgl1eAspPheLeuAsp-97 99-ArgGlyIleLysArg-103 236-ThrAsnTrpLysSerLysSer-242 248-LysIleArgThrPheSerArgAsnPheLysGlnArgGlnGluIleSerHis-264 273-LysProTyrLysArg-277 g246 AMPHI Regions - AMPHI 39-AlaValAsnIleAla-43 55-HisValValCysLysArgCysAlaGluValLeuValGluGlnPheAlaAspLeuPhePhe-74 83-AspMetGlyArgPhe-87 132-PheGlyCysAspAspValValAspAsnLeuAlaGlyPheGlyArgGlyPheArgPro-150 Antigenic Index - Jameson-Wolf l-MetTyrGlyArgAsnGlySerThrGln-9 17-AspGlnThrGlnArgAlaArgPheGlyAsnGlyGluVal-29 46-PheAlaGlyGluSerGlyGln-52 57-ValCysLysArgCysAla-62 78-AspCysGlyHisHisAspMetGlyArg-86 92-LeuAspAspLysLeuAla-97 133-GlyCysAspAspValValAsp-139 143-GlyPheGlyArgGlyPheArgProVal-151 165-LeuGlnGlnArgGly-169 Hydrophilic Regions - Hopp-Woods 18-GlnThrGlnArgAlaArgPheGlyAsn-26 47-AlaGlyGluSerGly-51 57-ValCysLysArgCysAla-62 92-LeuAspAspLysLeuAla-97 g247-l AMPHI Regions - AMPHI 34-GlyPheIleGlnArgLeu-39 59-ValValSerSerCysSerLysIleAlaLysProGlyLysLysIleSerThrLeuGlnGlu-78 105-TyrAlaValGlyArgPheGlyAsn-112 164-ArgTyrThrAsnLysPheAspLysSerLys-173 Antigenic Index - Jameson-Wolf l-ProGlyAlaLysGlnGluAsnProLeuPheSerLeuLysArgSerGlyMetAspLysGlnLeu-21 26-GluSerIleAspIleLysTyr-32 48-IleAspAspLeuAspAlaSerAla-55 62-SerCysSerLysIleAlaLysProGlyLysLysIleSerThrLeuGlnGluAlaLysSer-81 85-IleThrAsnAspAspLysGlnAsnGlyAsnIleThrArgGlnLysHis-lOO 109-ArgPheGlyAsnAsnGluGluSerLeu-117 120-PheGlnLeuAspAspLysGlyLysTrpGlyAsn-130 136-LysLysValLysArgMetAspVal-143 149-SerGlyCysProGluAspGluAspAlaGlyLysGluGluLysPheArgTyrThrAsnLysPheAspLysSer LysAsnAlaValThr-177 193-IleAlaAlaSerSerAspAsnSer-200 210-IleArgGlyGlyAsnValCysAlaAsnArgThrLeu-221 Hydrophilic Regions - Hopp-Woods l-ProGlyAlaLysGlnGluAsn-7 ll-SerLeuLysArgSerGlyMetAspLysGlnLeu-21 26-GluSerIleAspIleLys-31 48-IleAspAspLeuAspAlaSerAla-55 64-SerLysIleAlaLysProGlyLysLysIleSerThr-75 77-GlnGluAlaLysSer-81 86-ThrAsnAspAspLysGlnAsnGlyAsnIleThrArgGlnLysHis-lOO Hl-GlyAsnAsnGluGluSerLeu-117 121-GlnLeuAspAspLysGlyLysTrpGly-129 136-LysLysValLysArgMetAspVal-143 151-CysProGluAspGluAspAlaGlyLysGluGluLysPheArgTyr-165 167-AsnLysPheAspLysSerLysAsnAlaVal-176 193-IleAlaAlaSerSerAspAsn-199 g248-l AMPHI Regions - AMPHI 87-SerGluAsnCysGluLysGlyLeu-94 109-GluAlaPheGlyAsn-113 122-ValGluAlaValLysArg-127 153-AlaAlaGlyValSerLysMetProArgTyrIleIleGlu-165 173-GlnAsnValTyrArgValThrAlaLysAlaTrpGlyLysAsn-186 Antigenic Index - Jameson-Wolf l-MetArgLysGlnAsnThrLeuThr-8 ll-ProThrSerAspGlyGlnArgGlySer-19 40-GlnSerTyrAsnThrGluGlnArgIleSerAlaAsnGluSerAspArgLysLeuAla-58 64-AlaAlaLeuArgGluGlyGluPheGln-72 78-TyrAlaAlaAspSerLysValThrPheSerGluAsnCysGluLysGlyLeu-94 101-ArgThrAsnAsnAsnGlySerGluGluAlaPhe-lll 118-GlyLysProAlaValGluAlaValLysArgSerCysProAlaLysSerGlyLysAsnSerThr-138 140-LeuCysIleAspAsnLysGlyMetGluTyrAsnLysGlyAlaAlaGlyValSerLysMetProArgTyrIle -163 168-GlyValLysAsnGlyGlnAsnVal-175 182-AlaTrpGlyLysAsnAlaAsnThr-189 197-ValGlyAsnAsnAspGluGln-203 Hydrophilic Regions - Hopp-Woods l-MetArgLysGlnAsnThr-6 ll-ProThrSerAspGlyGlnArgGly-18 42-TyrAsnThrGluGlnArgIleSerAlaAsnGluSerAspArgLysLeuAla-58 64-AlaAlaLeuArgGluGlyGluPheGln-72 78-TyrAlaAlaAspSerLysValThrPhe-86 88-GluAsnCysGluLysGlyLeu-94 101-ArgThrAsnAsnAsnGlySerGluGluAlaPhe-lll 120-ProAlaValGluAlaValLysArgSerCysProAlaLysSerGlyLysAsnSerThr-138 140-LeuCysIleAspAsnLysGlyMetGluTyrAsnLys-151 199-AsnAsnAspGluGln-203 g249-l AMPHI Regions - AMPHI 6-CysLeuArgLeuLys-10 15-GlyMetAlaLeuIleGluValLeuVal-23 42-ThrValAlaSerValArgGluAla-49 53-ThrIleValSerGlnIleThrGlnAsnLeuMetGluGlyMet-66 lll-GluGlnLeuLysArgPheSerHisGluLeuLysAsnAlaLeu-124 Antigenic Index - Jameson-Wolf l-Me LysAsnAsnAspCysLeuArgLeuLysAsnProGlnSerGly-15 44-AlaSerValArgGluAlaGluThr-51 70-ProThrIleAspLeuAspSerAsnLysLysAsnTyr-81 85-MetGlyLysGlnThr-89 93-ValAspGlyGluPhe-97 99-LeuAspAlaGluLysSerLysAlaGlnLeuAlaGluGluGlnLeuLysArgPheSerHisGluLeuLysAsnA laLeu-124 134-ValCysLysAspSerSerGlyAspAlaProThrLeuSerAspSerGlyAlaPheSerSerAsnCysAspAsn LysAlaAsnGlyAspThrLeu-164 172-AspSerAlaGlyAspSerAspIleSerArgThrAsnLeuGluValSerGlyAspAsn-190 197-AlaArgValGlyGlyArgGlu-203 Hydrophilic Regions - Hopp-Woods l-MetLysAsnAsnAspCysLeuArgLeuLysAsnProGln-13 44-AlaSerValArgGluAlaGluThr-51 72-11eAspLeuAspSerAsnLysLysAsnTyr-81 99-LeuAspAlaGluLysSerLysAlaGlnLeuAlaGluGluGlnLeuLysArgPheSerHisGluLeuLysAsnA laLeu-124 134-ValCysLysAspSerSerGlyAspAlaProThrLeuSerAsp-147 154-AsnCysAspAsnLysAlaAsnGly-161 173-SerAlaGlyAspSerAspIleSerArgThrAsnLeu-184 199-ValGlyGlyArgGlu-203 g250 AMPHI Regions - AMPHI 10-GluPheIleArgGlyIleLysGlu-17 54-PheAlaGlyGlySerGlu-59 61-AlaThrValAsnLeuTrpAlaGluPro-69 Antigenic Index - Jameson-Wolf 3-HisThrAlaSerProArgAspGluPheIleArgGlyIleLysGluSerSerPro-20 34-MetGlnGlyGlyGlnLysGlyMetGlyArgLeu-44 54-PheAlaGlyGlySerGlu-59 83-AsnSerArgHisIleLeuMetGlyGlyGly-92 95-HisAlaHisGluArgAsnThrAlaGluLysSerArgAlaArg-108 Hydrophilic Regions - Hopp-Woods 5-AlaSerProArgAspGluPheIleArgGlyIleLysGluSerSer-19 36-GlyGlyGlnLysGlyMetGlyArg-43 95-HisAlaHisGluArgAsnThrAlaGluLysSerArgAlaArg-108 g251 AMPHI Regions - AMPHI 57-ValAlaAspPheGlyGlyIleGluGlyPhe-66 101-ArgThrValGlyGlyThrValArgLeuLeuLysMetIle-113 156-AlaArgThrValPheArgAlaHisLeuArg-165 179-AlaAlaArgValPheAlaValAla-186 200-LeuGlyGlnGluCysArg-205 207-ArgHisIleAlaArgValGluSerLeuLeuArgAlaPheGluTyrAla-222 Antigenic Index - Jameson-Wolf 21-LeuArgGlyArgPheGlnArg-27 48-ValValThrGluValAspAla-54 90-ArgLeuValGlyThr-94 120-ProValValArgGluAlaGlyIle-127 153-ValLysHisAlaArgThrValPhe-160 196-IleLysAsnArgLeuGlyGlnGluCysArgAsnArgHisIleAlaArgValGluSerLeu-215 231-LysThrLysThrArgAlaGluGlnProArgProAla-242 Hydrophilic Regions - Hopp-Woods 23-GlyArgPheGlnArg-27 48-ValValThrGluValAspAla-54 120-ProValValArgGluAlaGlyIle-127 153-ValLysHisAlaArgThrValPhe-160 198-AsnArgLeuGlyGlnGluCysArgAsnArgHisIleAlaArgValGluSerLeu-215 232-ThrLysThrArgAlaGluGlnProArg-240 g254 AMPHI Regions - AMPHI 6-ArgPheAsnThrTyrSerHis-12 32-GlyHisGlyAspGlyTyrArg-38 66-LysLeuLysSerIleLeuLys-72 142-ValLeuAlaValMetLysSerLeuThrAlaSer-152 Antigenic Index - Jameson-Wolf 5-GluArgPheAsnThrTyrSer-11 32-GlyHisGlyAspGlyTyrArg-38 65-GlyLysLeuLysSerIleLeuLysLysThrAspHis-76 94-SerLeuArgAsnGlyProGly-100 120-ThrIleGlyArgLysSerGluLysArgLeuLeu-130 177-AsnAspGluLysIleArgHisGlyHisGly-186 Hydrophilic Regions - Hopp-Woods 65-GlyLysLeuLysSerIleLeuLysLysThrAspHis-76 120-ThrIleGlyArgLysSerGluLysArgLeuLeu-130 177-AsnAspGluLys11eArgHis-183 g255 AMPHI Regions - AMPHI 23-ValLysThrCysAlaAspPheHisAlaPheAspGlyValAspAlaHisHisArg-40 71-GlyIleGlnGlyPheAlaHis-77 Antigenic Index - Jameson-Wolf 33-AspGlyValAspAlaHisHisArgValGlyAspPheGlyIleGluAlaValGluAsnGlyPheAlaGlnThrA spGlyAspValGlyGly-62 67-PheArgAlaAspGlyIleGlnGly-74 91-ValGlyGlyLysLysArgIleLeu-98 115-GlyAsnValGlyGlyAspPheArgAla-123 130-PhePheGlyAsnGlySerGlyGlyAsnAlaGly-140 145-GlyGlyThrProAla-149 168-SerGlyAlaGluGlyGlyGlyAspVal-176 Hydrophilic Regions - Hopp-Woods 33-AspGlyValAspAlaHisHisArgValGlyAspPheGly-45 56-ThrAspGlyAspValGlyGly-62 67-PheArgAlaAspGly-71 92-GlyGlyLysLysArgIleLeu-98 119-GlyAspPheArgAla-123 169-GlyAlaGluGlyGlyGly-174 g256-l AMPHI Regions - AMPHI 22-AlaLysPheLeuGlnHisPro-28 95-HisPheArgSerCysGlyGlyValAla-103 128-ArgTyrArgGluIleTyrAlaVal-135 143-AlaProAlaLysTyrLeuGlyGluGln-151 179-GlyIleThrArgLeuLeu-184 198-ArgSerLeuGlnGlyPheGlnThrAla-206 208-AlaAlaGlyCysLysThrLeuGlyGluPheAspAspArgPheThrAlaProLeuHisGly-227 234-TyrTyrArgGlnThrSerCysLysProLeuLeuLysHisValAla-248 Antigenic Index - Jameson-Wolf 4-ThrProProAspThrProPhe-10 12-LeuArgAsnGlyAsnAlaAspThrIleAla-21 27-HisProAlaProAlaTyrArgArgGluMetLeuProAspSerThrGlyLysThrLysThrAlaTyr-48 51-SerAlaGlyGlyIleSerProAspAlaPro-60 68-LeuGluGlySerSerArgSerHisTyr-76 84-ValArgAsnArgGlyTrpHis-90 98-SerCysGlyGlyValAlaAsn-104 113-GlyAspThrAlaGlu-117 125-LeuThrAlaArgTyrArgGlu-131 140-GlyGlyAsnAlaProAlaLysTyrLeuGlyGluGlnGlyLysLysAlaLeuPro-157 167-ValAspAlaGluAlaAlaGlySerArgPheAspSerGlyIle-180 193-LeuIleProLysAlaArgSerLeuGln-201 213-ThrLeuGlyGluPheAspAspArgPheThr-222 228-PheAlaAspArgHisAspTyrTyrArgGlnThrSerCysLysProLeuLeu-244 259-AspProPheLeuProProGluAlaLeuProArgAlaAspGluAlaSerGlu-275 283-AlaHisGlyGlyHis-287 292-SerSerThrGlyGlyArgLeu-298 312-AspSerPheArgThrAsnArgArg-319 Hydrophilic Regions - Hopp-Woods 31-AlaTyrArgArgGluMetLeuPro-38 40-SerThrGlyLysThrLysThr-46 69-GluGlySerSerArgSer-74 84-ValArgAsnArgGly-88 125-LeuThrAlaArgTyrArgGlu-131 147-TyrLeuGlyGluGlnGlyLysLysAlaLeuPro-157 167-ValAspAlaGluAlaAlaGlySerArgPheAspSerGlyIle-180 193-LeuIleProLysAlaArgSer-199 213-ThrLeuGlyGluPheAspAspArgPheThr-222 228-PheAlaAspArgHisAspTyrTyrArg-236 266-AlaLeuProArgAlaAspGluAlaSerGlu-275 314-PheArgThrAsnArgArg-319 g257 AMPHI Regions - AMPHI 24-SerPheLeuProAsn-28 73-AspLeuValAsnLysValLeuAlaGluValAlaArgLeuGluLysMetPhe-89 109-SerProProAlaAspPheLeuGluLeuLeuSerLeuAlaAlaIlePheThr-125 Antigenic Index - Jameson-Wolf 1-MetGlyArgHisPheGlyArgArgArgPheLeu-ll 32-AlaGlyGlyGluLysArgAsnMetAspLysLysArgAspGluAsn-46 56-GlySerGlyAlaGlu-60 65-GlyValAspAspArgGlnAlaAla-72 83-AlaArgLeuGluLys-87 92-TyrArgGluAspSerLeuIleSerArgLeuAsnArgAspGlyTyrLeuThrSerProProAlaAspPhe-114 Hydrophilic Regions - Hopp-Woods 4-HisPheGlyArgArgArgPheLeu-ll 33-GlyGlyGluLysArgAsnMetAspLysLysArgAspGluAsn-46 65-GlyValAspAspArgGlnAlaAla-72 83-AlaArgLeuGluLys-87 92-TyrArgGluAspSerLeuIle-98 100-ArgLeuAsnArgAspGlyTyr-106 g259-l Antigenic Index - Jameson-Wolf 34-LysAlaTyrThrGluGluLeuProPro-42 62-ValArgSerLysAlaLysAlaGluLysPheTyrArgGluLysMetIleGln-78 93-LeuGluHisLysPro-97 105-LysAsnHisGlyLysGlyMetAlaGluGlnValArgPheLysAla-119 121-ValLeuProAspAspGluAspAlaArgThrIleAla-132 144-GlyThrAspAlaValAlaSerGlyGluThrTyrGlyArgVal-157 Hydrophilic Regions - Hopp-Woods 35-AlaTyrThrGluGluLeuPro-41 62-ValArgSerLysAlaLysAlaGluLysPheTyrArgGluLysMetIleGln-78 93-LeuGluHisLysPro-97 106-AsnHisGlyLysGlyMetAlaGluGlnValArgPheLysAla-119 121-ValLeuProAspAspGluAspAlaArgThrIleAla-132 g260 AMPHI Regions - AMPHI 12-ProPhePheSerLeuPheArgAlaLeuPheGlu-22 53-PheIleAspSerValGlyGlnIleThrAlaArgPhePheGlnAlaPhe-68 151-GlnTyrLeuAlaArgIleAsnGlnValGlyIleValAspLeuIleProValArg-168 177-ThrGlyCysThrGlyIleCysProLysTyrProThrGlyCysArgPro-192 Antigenic Index - Jameson-Wolf 3O-GlyAlaHisAspAlaAlaGlu-36 80-ProAlaPheArgAlaArgGluGlnAlaArgArgGlySerGly-93 97-GlyAsnAspLeuArgValLeuHisLysAspAlaValGluValAspIleAspGlyGlyAsnThrVal-ll! 126-ThrAspPheAspAspGlyAspAla-133 139-AlaGluAlaArgPhe-143 166-ProValArgAlaProGlnGlyGlyThrIle-175 183-CysProLysTyrProThrGlyCysArgProVal-193 Hydrophilic Regions - Hopp-Woods 3 O-GlyAlaHisAspAlaAlaGlu-36 82-PheArgAlaArgGluGlnAlaArgArgGlySer-92 98-AsnAspLeuArgValLeuHisLysAspAlaValGluValAspIleAspGly-114 126-ThrAspPheAspAspGlyAspAla-133 139-AlaGluAlaArgPhe-143 g261 AMPHI Regions - AMPHI 19-PheThrPheGlnThr-23 32-AspThrAlaArgAlaPheAlaAlaAla-40 50-GlyLeuPheAlaAspVal-55 138-ValHisLysGlyIleGlyAsnAlaValValGlyGlyPheAsp-151 164-GlyValValArgAsnLeu-169 203-GluGlyAspGlyLeuAspValPheAlaProVal-213 217-CysLeuAsnGlnAlaGlyGly-223 Antigenic Index - Jameson-Wolf 13-AlaArgSerAspGly-17 23-ThrPheArgGlnProAla-28 40-AlaAlaAspAspThrLeu-45 62-ValArgGlnArgProArgLeuArgLeu-70 74-HisGlnArgArgValAspLeu-80 86-ArgGlnIleLysGlyAsnValHisGlyPheAspGluHisAla-99 lll-AlaHisAlaArgAspAspValProAsp-119 122-ProPheGlyLysAsnGlyGlyValLysGlnGluLysArgValThrProVal-138 149-GlyPheAspGlyGlyGlyPheAspGlyGlyGly-159 183-GlnIleLeuArgAspProLeuCysAla-191 201-ValSerGluGlyAspGlyLeuAsp-208 219-AsnGlnAlaGlyGlyArgIleLeuThrAlaArgGluAspAspGlnGlyPhe-235 Hydrophilic Regions - Hopp-Woods 13-AlaArgSerAspGly-17 40-AlaAlaAspAspThrLeu-45 62-ValArgGlnArgProArgLeuArgLeu-70 74-HisGlnArgArgValAspLeu-80 94-GlyPheAspGluHisAla-99 112-HisAlaArgAspAspValProAsp-119 127-GlyGlyValLysGlnGluLysArgValThrPro-137 202-SerGluGlyAspGlyLeu-207 226-LeuThrAlaArgGluAspAspGlnGly-234 g263 AMPHI Regions - AMPHI 32-AsnLeuIleGlyValLeuAlaAsnAla-40 42-GluAlaLeuAlaPheTyrGlnGluValGlyLysLeuAsnAlaAlaAsnSerLeuThr-60 65-GluValIleArgIle-69 86-LysLeuAlaThrLeuLysLys-92 lOO-AsnAlaAlaArgAlaLeu-105 115-LeuGlyAlaLeuAlaAlaPheThrGln-123 137-LeuAsnAlaPheLeuGluAla-143 157-ValAlaLeuAlaThrLeuCysAsnTyrAlaAsnAsnLeuAla-170 Antigenic Index - Jameson-Wolf 10-GluThrAlaProGluAlaAlaLysProArgValGluAlaValProLysAsnAsnGlyPhe-29 62-GlyGluValGluVal-66 73-ArgThrAsnGlnCysSer-78 97-GlnSerLeuAsnAla-lOl 108-GlyLysSerAspAspAlaLysLeu-115 126-MetAlaLysLysGlyAlaValSerAspAspGluLeu-137 144-GlyTyrAsnArgGlnGlnAla-150 172-ThrGluIleAsnProLysLeu-178 Hydrophilic Regions - Hopp-Woods ll-ThrAlaProGluAlaAlaLysProArgValGluAlaValProLys-25 62-GlyGluValGluVal-66 97-GlnSerLeuAsnAla-101 108-GlyLysSerAspAspAlaLysLeu-115 126-MetAlaLysLysGlyAlaValSerAspAspGluLeu-137 g 64 AMPHI Regions - AMPHI 28-ValValLysProGluLys-33 40-ArgSerTyrLysValAlaGluPheThrGlnThrGly-51 85-IleProSerHisValArgVal-91 113-AsnArgIleIleAspValSer-119 172-LeuAsnGlnAlaAlaGlnAsnPhe-179 Antigenic Index - Jameson-Wolf 27-AlaValValLysProGluLysLeuHisAlaSerAlaAsnArgSerTyrLys-43 48-ThrGlnThrGlyAsnAlaSerTrp-55 57-GlyGlyArgPheHisGlyArgLysThrSerGlyGlyAspArgTyrAsp-72 91-ValThrAsnThrLysAsnGlyLysSerVal-100 103-ArgValAsnAspArgGlyProPheHisGlyAsnArgIleIleAspValSerLysAlaAlaAla-123 142-ValProGlyGlnSerAlaProValAlaGluAsnLysAspIlePheIle-157 159-LeuLysSerPheGlyThrGluHisGluAla-168 181-AlaSerSerSerSerProAsnLeuSerValGluLysArgArgTyrGluTyr-197 205-AlaSerGlnGluArgAlaAlaGluAlaGluAlaGlnAla-217 Hydrophilic Regions - Hopp-Woods 27-AlaValValLysProGluLysLeuHisAlaSerAlaAsnArgSerTyrLys-43 60-PheHisGlyArgLysThrSerGlyGlyAspArgTyrAsp-72 92-ThrAsnThrLysAsnGlyLys-98 104-ValAsnAspArgGlyProPheHis-lll 114-ArgIleIleAspValSerLysAlaAlaAla-123 148-ProValAlaGluAsnLysAspIlePheIle-157 160-LysSerPheGlyThrGluHisGluAla-168 188-LeuSerValGluLysArgArgTyrGluTyr-197 205-AlaSerGlnGluArgAlaAlaGluAlaGluAlaGlnAla-217 g266 Antigenic Index - Jameson-Wolf 2-GlnPheArgArgHisArgArgArgGlnCysProAsnArgLysPro11e-17 47-AlaLeuLysArgLysHisPhe-53 76-SerArgAlaGlyAla-80 110-TrpHisThrArgAsnArgGlu-116 Hydrophilic Regions - Hopp-Woods 2-GlnPheArgArgHisArgArgArgGlnCysProAsnArgLysProIle-17 47-AlaLeuLysArgLysHisPhe-53 76-SerArgAlaGlyAla-80 g268-l AMPHI Regions - AMPHI 42-GluIleLeuValLysLeuValArg-49 57-ValLysThrPheAspAsp-62 77-HisIleArgArgMetValGluArg-84 92-ValArgThrThrGluLysThr-98 129-IleGlyAsnSerHisLys-134 136-ThrProAspPhePheGluProTyr-143 169-PheAlaGluLeuSerGlnAlaHisAspIleIleHisProLeuSerGluLeuValSerMet-188 191-IleLysGluProLeuAspLys-197 215-AlaArgGluAlaGluGluAlaAla-222 231-GlnGluAlaAlaArgValSerGluTrp-239 249-GluPheGluGlnPheTrpLysGlyLeuProGlnThrValGlnAsn-263 268-SerGlnLysThrTrpLysSerGlyMetAspLys-278 289-GluThrProAsnGlyIleLys-295 Antigenic Index - Jameson-Wolf l-Me LysLysAsnLeu-5 16-LeuSerGlyCysAspArgLeuGlyIleGlyAsnProPheSerGlyLysGluIleSerCysGlySerGluGluT hrLysGluIleLeu-44 47-LeuValArgAspAsnValGluGlyGluThrValLysThrPheAspAspAspAlaPheLysAspGlnAlaPhe- 70 77-HisIleArgArgMetValGlu-83 85-LeuGlyIleThrValAspGluValArgThrThrGluLysThrAspThrSerSerLysLeuLysCysGluAlaA laLeu-110 112-LeuAspValProAspAspValVal-119 127-GlnSerIleGlyAsnSerHisLysLysThrProAspPhePhe-140 143-TyrTyrArgLysGluGlyAlaTyr-150 158-SerValGlnProThrAspAspLysSerLysIle-168 190-LeuIleLysGluProLeuAspLysAlaLysGlnArgAsnGluLysLeuGluAlaAlaGluAlaThrAlaGln GluAlaArgGluAlaGluGluAlaAlaAla-223 226-AlaLeuGlyArgGluGlnGluAlaAlaArgValSerGluTrpGluGluArgTyrLysLeuSerArgSerGlu Phe-250 261-ValGlnAsnLysLeuGlnAlaSerGlnLysThrTrpLysSerGlyMetAspLysIleCysAlaAsnAsnAla LysAlaGluGlyGluThrProAsnGlylleLysValSerGluLeuAlaCysLysThrAlaGluThrGluAlaArgL euGluGluLeuHisAsnArgLysLysAlaLeuIle-321 323-GluMetValArgGluGluAspLysLysGluLeuProLysArgLeu-337 Hydrophilic Regions - Hopp-Woods l-MetLysLysAsnLeu-5 18-GlyCysAspArgLeuGly-23 28-PheSerGlyLysGluIleSerCysGlySerGluGluThrLysGluIleLeu-44 47-LeuValArgAspAsnValGluGlyGluThrValLysThrPheAspAspAspAlaPheLysAspGlnAlaPhe- 70 77-HisIleArgArgMetValGlu-83 85-LeuGlyIleThrValAspGluValArgThrThrGluLysThrAspThrSerSerLysLeuLysCysGluAlaA laLeu-110 112-LeuAspValProAspAspValVal-119 131-AsnSerHisLysLysThrProAspPhe-139 143-TyrTyrArgLysGluGly-148 161-ProThrAspAspLysSerLysIle-168 190-LeuIleLysGluProLeuAspLysAlaLysGlnArgAsnGluLysLeuGluAlaAlaGluAlaThrAlaGln GluAlaArgGluAlaGluGluAlaAlaAla-223 226-AlaLeuGlyArgGluGlnGluAlaAlaArgValSerGluTrpGluGluArgTyrLysLeuSerArgSerGlu Phe-250 270-LysThrTrpLysSerGlyMe AspLysIleCys-280 283-AsnAlaLysAlaGluGlyGluThrProAsn-292 294-IleLysValSerGluLeuAlaCysLysThrAlaGluThrGluAlaArgLeuGluGluLeuHisAsnArgLys LysAlaLeuIle-321 323-GluMetValArgGluGluAspLysLysGluLeuProLysArgLeu-337 g269 AMPHI Regions - AMPHI 36-LysProCysAlaSerLeuAspAlaSerSerAla-46 54-TrpAspPheIleArgAsnThrAlaSerPro-63 73-PheLysThrArgAlaLeuGlyArgPheSer-82 Antigenic Index - Jameson-Wolf 28-TrpSerArgSerAlaPheSerCysLysProCysAla-39 58-ArgAsnThrAlaSerProLysVal-65 73-PheLysThrArgAlaLeuGlyArgPheSerAla-83 90-LeuSerAsnArgGlyValLysLysProLeuSerPheLysSerProSerValGlnValAspThrSerAla-112 117-SerLeuArgSerSer-121 Hydrophilic Regions - Hopp-Woods 60-ThrAlaSerProLysVal-65 73 -PheLysThrArgAlaLeuGly-79 93-ArgGlyValLysLysProLeuSer-100 g270 AMPHI Regions - AMPHI 13-LeuLeuThrAlaPheAlaAlaPhe-20 41-AspLeuThrGluGlyCys-46 49-ProAspGlySerArg-53 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnArgLysLeu-7 41-AspLeuThrGluGlyCysThrLeuProAspGlySerArgValArgAlaAlaAlaValSerThrLysLysProP he-65 71-HisAlaProAlaGlyThrGlu-77 86-LysAsnMetAspMetGlyPhe-92 95-TyrMetPheGluArgGlnProSerGlyThr-104 114-ValCysValGluGlyArgArgAspPheThrAla-124 128-IleGlySerArgThrPhe-133 Hydrophilic Regions - Hopp-Woods l-MetAsnLysAsnArgLysLeu-7 49-ProAspGlySerArgValArgAla-56 60-SerThrLysLysProPhe-65 73-ProAlaGlyThrGlu-77 96-MetPheGluArgGlnPro-101 116-ValGluGlyArgArgAspPheThrAla-124 g271-2 AMPHI Regions - AMPHI 6-MetAlaArgIleTrp-10 20-SerProCysProAla-24 29-ProLysSerProAla-33 Antigenic Index - Jameson-WoIf 2-PheSerSerArgMetAlaArg-8 25-LeuThrThrLysProLysSerProAlaLys-34 41-ArgSerAsnCysLeu-45 61-SerSerThrThrGlyAlaProThrSerArg-70 78-SerAlaSerIleAsnLysAspThrArgMetProAlaSerVal-91 102-CysCysAlaAsnThrSerLysProProSer-lll Hydrophilic Regions - Hopp-Woods 27-ThrLysProLysSerProAlaLys-34 80-SerIleAsnLysAspThrArgMet-87 105-AsnThrSerLysProPro-110 g272-2 AMPHI Regions - AMPHI 44-IleThrArgIleThrAspGlu-50 70-AlaGluGluPheSerSerThrAsn-77 106-PheArgAlaIleThrSer-lll 165-IleIleThrIleGluAspProIleGlu-173 194-AsnTrpMetAlaAlaLeuLysAsnThrLeuArgGlnAla-206 244-AsnGlnAlaLeuAspArgIleIleAsn-252 307-GlyAsnIleHisGluIleLysGluValMetLys-317 328-AspGlnHisLeuTyrGln-333 343-GlnAspAlaLeuLysAsnAlaAspSer-351 Antigenic Index - Jameson-Wolf 2-PheThrAspGluAsnMetThrAlaLysGluGluLeu-13 19-HisMetAsnLysAsnLysGlySerAsp-27 38-MetLysLeuAspGlyLysIleThrArgIleThrAspGluProLeuThrAlaGluLysCysMet-58 68-LysGlnAlaGluGluPheSerSerThrAsnGlu-78 85-LeuProAspThrSerArgPheArgVal-93 109-IleThrSerLysIleProLysPheGluSerLeuAsn-120 122-ProProAlaLeuLys-126 128-ValAlaLeuLysLysArgGly-134 142-ThrGlySerGlyLysSerThrSerLeu-150 154-IleAspTyrArgAsnGluAsnSerPheGly-163 168-IleGluAspProIle-172 176-HisGluHisLysAsnCys-181 184-ThrGlnArgGluValGlyValAspThrGluAsn-194 199-LeuLysAsnThrLeuArgGlnAlaProAsp-208 214-GluIleArgAspArgGluThrMet-221 241-AsnSerThrAsnGlnAlaLeuAspArg-249 254-PheProGluGluArgArgGluGlnLeuLeu-263 278-LeuValProArgAspGlyGlyLysGlyArgValAlaAla-290 310-HisGluIleLysGluValMetLysLysSerThr-320 336-GluLysGlyGluIleSerLeu-342 344-AspAlaLeuLysAsnAlaAspSerAlaHisAspLeu-355 361-LeuArgSerArgArgAlaGlnSerSerAspProAspLeuGluLeu-375 Hydrophilic Regions - Hopp-Woods 2-PheThrAspGluAsnMetThrAlaLysGluGluLeu-13 20-MetAsnLysAsnLysGlySerAsp-27 38-MetLysLeuAspGlyLysIleThrArgIleThrAspGluProLeuThrAlaGluLysCysMet-58 68-LysGlnAlaGluGluPheSerSer-75 87-AspThrSerArgPheArgVal-93 112-LysIleProLysPheGluSer-118 128-ValAlaLeuLysLysArgGly-134 143-GlySerGlyLysSerThrSer-149 155-AspTyrArgAsnGluAsnSer-161 168-IleGluAspProIle-172 176-HisGluHisLysAsn-180 184-ThrGlnArgGluValGlyValAspThr-192 201-AsnThrLeuArgGlnAlaPro-207 214-GluIleArgAspArgGluThrMet-221 245-GlnAlaLeuAspArg-249 255-ProGluGluArgArgGluGlnLeuLeu-263 278-LeuValProArgAspGlyGlyLysGlyArgValAlaAla-290 310-HisGluIleLysGluValMetLysLysSerThr-320 336-GluLysGlyGluIleSerLeu-342 344-AspAlaLeuLysAsnAlaAspSerAlaHisAspLeu-355 361-LeuArgSerArgArgAlaGlnSerSerAspProAspLeuGluLeu-375 g274 AMPHI Regions - AMPHI 31-TyrLysAspGlyLys-35 lll-GluAlaValPheLys-115 Antigenic Index - Jameson-Wolf 25-LeuValThrAspAspTyrTyrLysAspGlyLysHisIleAsp-38 40-GlnLeuHisArgAspGluGluAlaValArgArgHisIle-52 60-ProAspMetAsnAla-64 71-GlyGluPheAspGlyLysGlnPro-78 85-HisProThrArgLysAlaAspAspGlnThrVal-95 99-ProValGlySerAlaGlnAsnGlyArgAlaGluTyr-110 116-ThrLeuProProAlaAsnHis-122 126-ArgValGluAspAlaAlaGly-132 136-ValGluAsnLysTrpIleThrSerGlnGlyAsnAlaValAspLeuThrProMetAspLysLeuPheAsnAsn AlaGlySerLys-163 Hydrophilic Regions - Hopp-Woods 29-AspTyrTyrLysAspGlyLysHisIleAsp-38 40-GlnLeuHisArgAspGluGluAlaValArgArgHisIle-52 72-GluPheAspGlyLysGln-77 86-ProThrArgLysAlaAspAspGlnThrVal-95 104-GlnAsnGlyArgAlaGluTyr-llO 126-ArgValGluAspAlaAlaGly-132 151-ThrProMetAspLysLeuPhe-157 g276 AMPHI Regions - AMPHI 19-ArgArgTrpAlaThrMetMet-25 60-SerPheLysMetAlaArg-65 80-ProPheAspProMetGlyTrp-86 115-GlyArgLeuTyrArgThrPheSerAsn-123 164-ThrLysArgGlyArgArgLeuThr-171 207-SerThrSerThrLeuArgLysLeuMetArgProSerThr-219 Antigenic Index - Jameson-Wolf 9-MetMetArgSerAlaAspSerThrVal-17 29-PheSerIleArgArgSerSerAlaCysTrpThrArgArgSerAspSerLeuSer-46 52-SerSerAsnAsnAsnIle-57 67-MetAlaThrArgCysArgCysProProAspLysLeuLeuPro-80 82-AspProMetGlyTrp-86 88-SerProSerGlyAspAlaSerIleArg-96 103-TrpArgAlaAspArgThrSerAlaSerProAlaSerGlyArgLeuTyr-118 121-PheSerAsnArgValSerSerAsnArgAsnThrSerTrpGluThrArgAlaAsnTrpAlaArgArgGlnSer SerLeu-146 158-LeuProAlaAspGlySerThrLysArgGlyArgArgLeuThrThr-172 176-ProLeuProGluArgProThrArgAlaThrArgSerProCysLeu-190 194-LeuLysLeuSerArg-198 200-LeuMetProSerGluArgTyrSerThrSerThrLeuArgLysLeuMetArgProSerThrArgCysGlyAla -223 229-CysSerGlyGlyValSerArgAsnAlaHisThrProSerAlaAlaArgAsn-245 Hydrophilic Regions - Hopp-Woods 29-PheSerIleArgArgSerSer-35 38-TrpThrArgArgSerAspSerLeu-45 67-Me AlaThrArgCysArgCysProProAspLys-77 90-SerGlyAspAlaSerIleArg-96 104-ArgAlaAspArgThrSerAla-110 124-ArgValSerSerAsnArgAsnThrSerTrpGluThr-135 137-AlaAsnTrpAlaArgArgGlnSerSer-145 161-AspGlySerThrLysArgGlyArgArgLeuThrThr-172 176-ProLeuProGluArgProThrArgAlaThrArg-186 194-LeuLysLeuSerArg-198 200-LeuMetProSerGluArgTyrSer-207 210-ThrLeuArgLysLeuMetArgProSerThrArgCys-221 232-GlyValSerArgAsnAlaHis-238 g277-2 AMPHI Regions - AMPHI 39-GlyIleAlaValPheGluValValGlyArgLeuLeuAspPheValLeu-54 72-AsnGluValIleAspValPheHisAlaLeuGln-82 87-AlaPheAspAlaValGlyAsnPheAlaGluTyrGlyArgAlaIleAspThrAlaAspLeuLeuGluIleGlyL ysLeuGlyTyrPheHis-116 180-AlaValGlyValValAlaValAla-187 Antigenic Index - Jameson-Wolf l-MetProArgPheGluAspGlnLeuValGlyArgXxxGlyLysAla-15 68-ArgPheCysProAsnGluVal-74 96-GluTyrGlyArgAlaIleAspThr-103 118-ValGluProAspPheProAlaGlnThrProArgThrGluGlyGly-132 138-PheAspLysAlaAspValVal-144 162-AsplleGlyGlyGlyGlyPheGluGlyAspLeu-172 196-LeuAspValGlyGlyLysProArgLeuGlyAlaGluArgAlaGlnAlaGlyGlyGlyMetGlyCysAlaGly ThrAspPheHis-223 226-GlyLeuAspAspGlyAla-231 237-GluGlyLeuGlnPheGluAspAspLeuLeuGluGlyLysHisGlyLeu-252 Hydrophilic Regions - Hopp-Woods 2-ProArgPheGluAspGlnLeuVal-9 96-GluTyrGlyArgAlaIleAspThr-103 118-ValGluProAspPhe-122 126-ThrProArgThrGluGly-131 138-PheAspLysAlaAspValVal-144 167-GlyPheGluGlyAspLeu-172 198-ValGlyGlyLysProArgLeuGlyAlaGluArgAlaGlnAla-211 226-GlyLeuAspAspGlyAla-231 239-LeuGlnPheGluAspAspLeuLeuGluGlyLysHisGlyLeu-252 g278-2 AMPHI Regions - AMPHI 20-IleGlyProLeuProSerIleGlyArg-28 42-ThrGlyThrSerLys-46 101-ArgThrIleProSerValThrGluIleThrValProArgValLeuThrSerAlaPhe-119 123-PheSerIleLeuAlaLeuIleArgSerLeuIleSer-134 157-LeuTyrArgGlnIleGlnAsnLeuIleThrHisPheAsnPheTyrAlaAla-173 189-GluThrLeuIleGlnHisLeuArgGlnLeuAlaAsp-200 Antigenic Index - Jameson-Wolf 25-SerIleGlyArgProAsnAlaSerThrThrArgProThrAsnSerArgProThrGlyThrSerLysIleArgP ro-49 63-SerProAsnThrThrAlaProThrGluSerArgSerArgPheIleAla-78 80-ProLysValLeuProGlyAsnSerSerIle-89 93-IleAlaSerAspLysProTrpMetArg-101 119-PheThrAspArgPheSer-124 146-ArgHisSerArgValGlnSerThr-153 178-PheAspPheAspArgAspPheGlnLeu-186 209-ThrValAsnAspGlyArgPheAspMetValGlu-219 Hydrophilic Regions - Hopp-Woods 27-GlyArgProAsnAlaSerThrThrArgProThrAsnSerArgProThrGlyThrSerLysIleArgPro-49 68-AlaProThrGluSerArgSerArgPheIleAla-78 93-IleAlaSerAspLysProTrp-99 146-ArgHisSerArgValGln-151 178-PheAspPheAspArgAspPhe-184 211-AsnAspGlyArgPheAspMetValGlu-219 g279 AMPHI Regions - AMPHI 6-GlyCysLeuIleSer-10 58-LeuProAlaIleThrThr-63 Antigenic Index - Jameson-Wolf 28-GlnTrpGluGlyThrAspThrGlySerGlyArgAlaArgLeuAla-42 64-CysProGlyGluLeuLysLeuThr-71 74-ThrThrSerProCysAlaAspSer-81 88-CysSerSerSerLysProLysMet-95 102-ProCysGlyThrAlaAspCysIleSerSerAlaArgArgArgThrSerLeu-118 120-AlaSerAlaLysSerAsnAlaSer-127 148-ProProThrSerLys-152 Hydrophilic Regions - Hopp-Woods 29-TrpGluGlyThrAspThrGlySerGlyArgAlaArgLeuAla-42 66-GlyGluLeuLysLeu-70 89-SerSerSerLysProLysMet-95 110-SerSerAlaArgArgArgThrSerLeu-118 120-AlaSerAlaLysSerAsnAla-126 g280 AMPHI Regions - AMPHI 27-SerPheSerIleLeuGlyAspValAlaLys-36 64-AsplleLysLys11eArgSerAla-71 85-AspIleGlnArgAlaValLys-91 97-TyrAlaGluAlaThrLysGlyIleGlnProLeuLys-108 150-AspTyrAlaGlnAsnValAlaGluThrLeuIleLys-161 237-ValAlaAlaIleIleArgGlnIleLys-245 247-GluGlyIleLysAlaValPheThrGlu-255 258-LysAspThrArgMetValAspArgIleAlaLysGluThr-270 278-LeuTyrSerAspAlaLeuGlyAsnAlaProAlaAspThrTyrIle-292 Antigenic Index - Jameson-Wolf 38-IleGlyGlyGluArgValAla-44 51-AlaAsnGlnAspThrHis-56 61-ThrSerGlyAspIleLysLysIleArgSerAlaLys-72 82-GluAlaAlaAspIleGlnArgAlaValLysGlnSerLysValSerTyrAlaGluAlaThrLysGlyIleGln- 105 107-LeuLysAlaGluGluGluGlyGlyHisHisHisAspHisHisHisAspHisAspHisAspHisGluGlyHis HisHisAspHisGlyGluTyrAspProHisValTrpAsnAspProValLeu-147 158-ThrLeuIleLysAlaAspProGluGlyLysValTyrTyr-170 180-GlnLeuLysLysLeuHisSerAspAla-188 196-ProAlaAlaLysArgLysValLeuThr-204 212-MetGlyAsnArgTyr-216 224-GlnGlyValSerSerGluAlaGluProSerAlaLysGln-236 242-ArgGlnIleLysArgGluGlyIle-249 255-GluAsnIleLysAspThrArgMetValAspArgIleAlaLysGluThrGlyVal-272 274-ValSerGlyLysLeuTyrSer-280 286-AlaProAlaAspThr-290 295-TyrArgHisAsnVal-299 Hydrophilic Regions - Hopp-Woods 38-IleGlyGlyGluArgValAla-44 63-GlyAspIleLysLysIleArgSerAlaLys-72 82-GluAlaAlaAspIleGlnArgAlaValLysGlnSerLys-94 99-GluAlaThrLysGly-103 107-LeuLysAlaGluGluGluGlyGlyHisHisHisAspHisHisHisAspHisAspHisAspHisGluGlyHis HisHisAspHisGlyGluTyrAsp-138 158-ThrLeuIleLysAlaAspProGluGly-166 180-GlnLeuLysLysLeuHisSerAspAla-188 196-ProAlaAlaLysArgLysValLeuThr-204 226-ValSerSerGluAlaGluProSerAlaLysGln-236 242-ArgGlnIleLysArgGluGlyIle-249 255-GluAsnIleLysAspThrArgMetValAspArgIleAlaLysGluThrGlyVal-272 g281 AMPHI Regions - AMPHI 62-AlaAlaGlyMetLeuMetAlaLeuLeuAlaGlyLeuValSerArgPhe-77 126-LeuGlnLeuIleAlaAlaValSerGlyLeuThr-136 179-LeuValSerGlyPheGlnAlaLeuGlyIleLeu-189 216-SerValLeuIleAlaLeuPheCysGlyLeuIleGlyLeu-228 Antigenic Index - Jameson-Wolf 25-ArgArgMetSerLeu-29 78-ThrThrLeuLysGluAspAlaAsn-85 102-SerLysAsnGlySerSerVal-108 158-LysSerValAsnGlyLysGlyGly-165 236-IleProSerGlyPro-240 256-LeuGlyLysGluGlyGlyIle-262 266-TrpPheLysAsnHisArgHisHisThrThr-275 Hydrophilic Regions - Hopp-Woods 25-ArgArgMetSerLeu-29 78-ThrThrLeuLysGluAspAlaAsn-85 103-LysAsnGlySerSer-107 256-LeuGlyLysGluGlyGlyIle-262 270-HisArgHisHisThr-274 g282 AMPHI Regions - AMPHI 10-LeuIleValAlaLeuLeuValLeuIleAsnProPheSerAlaLeu-24 50-ValPheAlaValIleAlaValPheAlaLeuIleGlyGlyAlaLeu-64 112-ArgProAlaArgAsn-116 176-ValSerArgLeuLeu-180 186-ThrIleLeuAsnArgIleMetGlyMet-194 Antigenic Index - Jameson-Wolf 31-ThrAsnGlyHisSerThrLysGluArgArgLysValAlaArg-44 92-AsnGlyAsnAspAsnProAlaLysGlnAsnLeuGlyAlaGlnProGluThrGlyGlnAlaArgProAlaArgA snAlaGly-118 Hydrophilic Regions - Hopp-Woods 34-HisSerThrLysGluArgArgLysValAlaArg-44 92-AsnGlyAsnAspAsnProAlaLysGlnAsnLeu-102 104-AlaGlnProGluThrGlyGlnAlaArgProAlaArgAsn-116 g283 AMPHI Regions - AMPHI 32-GlyGlyAsnSerTyrSerAspValProLysGlnLeuHis-44 48-SerGlnIleLeuAsnLeu-53 Antigenic Index - Jameson-Wolf 28-TrpLysAspGlyGlyGlyAsnSerTyrSerAspValProLysGlnLeuHisProAspGlnSerGln-49 55-ThrLeuGlnThrLysProAlaValLysProLysProAlaValAspThrAsnAlaAspSerAlaLysGluAsnG luLysAspIleAlaGluLysAsnGlyGlnLeuGluGluGluLysLysLysIleAlaGluThrGluArgGlnAsnLy sGluGluAsnCysArgIleSerLysMetAsnLeu-115 119-GlyAsnSerAsnAlaLysAsnLysAspAspLeuIleArgLysTyrAsnAsnAlaValAsnLysTyrCysArg -142 Hydrophilic Regions - Hopp-Woods 35-SerTyrSerAspValProLys-41 43-LeuHisProAspGlnSerGln-49 60-ProAlaValLysProLysProAlaValAspThrAsnAlaAspSerAlaLysGluAsnGluLysAspIleAlaG luLysAsnGlyGlnLeuGluGluGluLysLysLysIleAlaGluThrGluArgGlnAsnLysGluGluAsnCysAr gIleSerLysMetAsnLeu-115 121-SerAsnAlaLysAsnLysAspAspLeuIleArgLysTyrAsn-134 g284-2 AMPHI Regions - AMPHI 43-GluAlaPheAlaGlyPhePheGluThrVal-52 61-ThrPheAlaAlaArgPhe-66 125-ValAspPheAspValPhe-130 154-ValValPheArgLeuPheArgGln-161 174-AsnThrAlaCysGlyAsnValGlyGly-182 186-PheAlaAlaAlaPhe-190 216-PheValGlnPheIleArgAspAspPheGlyHisArg-227 277-PheArgValPheGlyGlnPheAlaArgGlnPheAlaAspCysAlaVal-292 310-AspGlyPheAspValValAspLys-317 342-LeuHisGlnValArgGlnThrAlaArgSerGlyAspAsnGlnIleAspArgPheAlaGln-361 381-AlaHisIlePheGly-385 387-ArgGlnCysValPhe-391 408-ArgAlaPheAlaArgPhePheAlaAlaPheGlyGlnSerLeuGlnSer-423 Antigenic Index - Jameson-Wolf l-MetProSerGluThrArgAsnArgPhe-9 107-HisAlaPheAspGlyGlnPhe-113 132-HisPheGlyLysArgAsnArgAsnThrArgAla-142 147-GlyAlaProAspAlaVal-152 167-ValGlyAsnGlyArgTyrVal-173 178-GlyAsnValGlyGlyAsnGlnAsn-185 192-GlnIleArgGlnArgAlaVal-198 209-AlaValGlyGlyGlu-213 219-PheIleArgAspAspPheGlyHisArgPheGlyGlyArgGluAsnHisThr-235 292-ValProSerGlyGlyGluGlnXxxSer-300 303 -ValGlyArgGlyGlyPheHisAspGlyPheAspValValAspLysAlaHis-319 346-ArgGlnThrAlaArgSerGlyAspAsnGlnIleAspArgPheAla-360 362-GlyAlaGlyLeuValAlaGluArgCysAlaAlaAspAspAlaAspGlyAlaGluPro-380 393-AspLeuArgArgGlnPheAlaGlyArgCysGlnHisGlnArgAlaArgAla-409 419-GlnSerLeuGlnSerArg-424 Hydrophilic Regions - Hopp-Woods l-MetProSerGluThrArgAsnArgPhe-9 134-GlyLysArgAsnArgAsnThrArgAla-142 193-IleArgGlnArgAlaVal-198 220-IleArgAspAspPheGlyHis-226 228-PheGlyGlyArgGluAsnHisThr-235 294-SerGlyGlyGluGlnXxx-299 313-AspValValAspLysAlaHis-319 346-ArgGlnThrAlaArgSerGlyAspAsnGlnIleAspArgPheAla-360 366-ValAlaGluArgCysAlaAlaAspAspAlaAspGlyAlaGlu-379 393-AspLeuArgArgGlnPheAla-399 402-CysGlnHisGlnArgAlaArgAla-409 g285-l AMPHI Regions - AMPHI 15-ValCysPheLeuGly-19 34-GlnIleProSerTrp-38 50-GlyThrLeuLeuAspGlyPheAsp-57 115-GlnGlyLeuProAspSerIleAspLeuPro-124 208-HisSerThrAlaArg-212 240-HisProPheAlaGluSerLeuAspLysThrLeuGluGluValLeu-254 266-ValProSerLeuPro-270 280-AlaIleProSerPheSerAsp-286 313 -GlnValLeuGlyGly-317 592-IleGlyLysAlaAlaAspIle-598 671-GlyIleAsnArgGluLeuThrArgTrp-679 745-LeuHisIleAlaGluLeuHisAsnPhePheLysProProPhe-758 836-PheGlyGlyAsnMetAlaAsn-842 848-ArgIleThrAlaSerLeu-853 855-AspLeuGlyAlaLeu-859 868-GlnAsnIleThrGlySer-873 955-GlySerIleAlaAsp-959 1008-ThrAlaGluLeuSer-1012 1061-ValThrGlyMetIleLys-1066 1137-GlyAsnValArgGlyValGlyThrValArg-1146 1165-ThrValSerPheValGlyProLeuAsn-1173 1190-AlaGlyValGluIleLeuGlySerLeuAsn-1199 1244-LeuAlaGlyGlnIle-1248 1305-ValLysLeuIleTyrArgLeuThrArgAlaIleGlnAlaValAlaArgIleGlySer-1323 1335-ArgPheAspArgLeuPheGly-1341 Antigenic Index - Jameson-Wolf 43-IleSerSerGlnAsnLeuLysGlyThrLeuLeuAspGlyPheAspGlyAspAsnTrpSerIleGluThrGluG lyAlaAspLeuLysIleSerArg-74 80-LysProSerGluLeuMetArgArgSerLeuHis-90 104-LysProThrProProLysGluGluArgProProGlnGlyLeuProAspSerIleAsp-122 130-AspArgPheGluThrGlyLysIleSerMetGlyLysThrPheAspLysGlnThrValTyr-149 157-TyrArgTyrAspArgLysGlyHisArgLeuAspLeuLysAlaAlaAspThrProTrpSerSerSerSerGly SerAla-182 185-GlyLeuLysLysProPheAla-191 198-ThrLysGlyGlyPheGluGlyGluThrIle-207 209-SerThrAlaArgLeuSerGlySerLeuLysAspValArgAla-222 224-LeuThrIleAspGlyGlyAsnIleArgLeuSerGlyLysΞer-237 244-GluSerLeuAspLysThrLeuGlu-251 268-SerLeuProAspAla-272 292-GlySerLeuAspLeuGluAsnThrLys-300 302-GlyPheAlaAspArgAsnGlyIleProVal-311 320-IleArgGlnAspGlyThrVal-326 337-GlyArgGlyGlyIleArgLeuSerGlyLysIleAspThrGluLysAspIleLeu-354 362-SerValGlyAlaGluAspValLeu-369 372-AlaPheLysGlyArgLeuAspGlySerIle-381 386-ThrThrAlaSerProLysIle-392 397-GlyThrGlyThrAlaArgThrAspGlySerLeu-407 411-SerAspProAlaAsnGluGlnArgLysLeuVal-421 428-SerAlaGlyGluGlySerLeuThr-435 442-LeuPheLysAspArgLeuLeuLysLeuAspIleArgSerArgAlaPheAspProSerArgIleAspProGln PheProAlaGlyAspIleAsnGly-473 480-GluLeuAlaLysGluLysPheThrGlyLys-489 508-IleValTyrGluSerArgHisLeuProArgAlaAlaVal-520 522-LeuArgLeuGlyArgAsnIleValLysThrAspGlyGlyPheGlyLysLysGlyAspArgLeuAsn-543 548-AlaProAspLeuSerArgPheGly-555 563-AsnValArgGlyHisLeuSerGlyAspLeuAspGlyGlyIleArgThrPheGluThrAspLeuSerGlyThr AlaArg-588 594-LysAlaAlaAspIleArgSer-600 605-LeuLysGlySerProGlyThrSerArgProMetArgAlaAspIleLysGlyGlyArgLeu-624 641-GluGlyThrGlyAla-645 647-HisArgIleArgThr-651 657-LeuAspGlyLysProPheLysLeuAspLeuAspAlaSerGlyGlyIleAsnArgGluLeuThrArgTrpLys GlySerIle-683 696-LeuGlnAsnArgMetThrLeu-702 729-SerTrpAspArgLysThrGlyl1eSerAlaLysGlyGlyAlaArgGly-744 764-LeuAsnGlyAspTrp-768 774-HisAsnAlaArgGly-778 782-IleSerArgGlnSerGlyAspAlaValLeu-791 803-SerLeuLysThrArgPheGlnAsnAspArgIleGly-814 817-LeuAspGlyGlyAlaArgPheGlyArgIleAsnAla-828 844-ProLeuGlyGlyArgIleThr-850 880-IleGlyGlyArgValGlySerProSerVal-889 893 -ValAsnGlySerSerAsnTyrGlyLys11eAsnGly-904 908-ValGlyGlnSerArgSerPheAspThrAlaProLeuGlyGlyArg-922 928-AlaAspAlaGluAlaPhe-933 941-GlnThrValLysGlySerLeu-947 956-SerIleAlaAspProHisLeuGlyGly-964 966-11eAsnGlyAspLysLeuTyrTyrArgAsnGlnThr-977 982-LeuAspAsnGlySerLeuArg-988 991-IleAlaGlyArgLysTrpVal-997 1001-LeuLysPheArgHisGluGlyThrAlaGluLeuSerGly-1013 1015-ValSerMetGluAsnSerValProAspValAspIle-1026 1031-AspLysTyrArgIleLeuSerArgProAsnArgArgLeuThr-1044 1047-GlyAsnThrArgLeuArgTyrSerProGlnLysGlyIle-1059 1065-IleLysThrAspGlnGlyLeuPheGlySerGlnLysSerSerMetProSerValGlyAspAspVal-1086 1091-GluValLysLysGluAlaAlaAla-1098 1109- spLeuAsnAspGlyIleArgPhe-1116 1134-GlnProGlyGlyAεnValArgGlyValGly-1143 1146-ArgValIleLysGlyArgTyrLysAlaTyrGlyGlnAspLeuAspIleThrLysGlyThr-1165 1171-ProLeuAsnAspProAsnLeuAsnIleArgAlaGluArgArgLeuSerProValGly-1189 1197-SerLeuAsnSerProArgIle-1203 1207-AlaAsnGluProMetSerGluLysAspLysLeu-1217 1225-AlaGlySerGlySerSerGlyAspAsnAlaAla-1235 1246-GlyGlnIleAsnAspArgIleGlyLeu-1254 1256-AspAspLeuGlyPheThrSerLysArgSerArgAsnAlaGlnThrGlyGluLeuAsnProAlaGlu-1277 1283-GlyLysGlnLeuThrGlyLys-1289 1298-IleSerSerAlaGluGlnSerVal-1305 1321-IleGlySerArgSerSerGlyGlyGluLeu-1330 1335-ArgPheAspArgLeuPheGlySerAspLysLysAspSerAlaGlyAsnGlyLysGlyLys-1354 Hydrophilic Regions - Hopp-Woods 56-PheAspGlyAspAsnTrpSerIleGluThrGluGlyAlaAspLeuLyεlleSerArg-74 83-GluLeuMetArgArgSerLeuHis-90 105-ProThrProProLysGluGluArgProProGlnGlyLeu-117 130-AspArgPheGluThrGlyLys-136 141-LysThrPheAspLys-145 157-TyrArgTyrAspArgLysGlyHisArgLeuAspLeuLysAlaAlaAsp-172 200-GlyGlyPheGluGlyGluThrIle-207 215-GlySerLeuLysAspValArgAla-222 244-GluSerLeuAspLysThrLeuGlu-251 292-GlySerLeuAspLeuGluAsnThrLys-300 302-GlyPheAlaAspArgAsnGlyIlePro-310 320-IleArgGlnAspGly-324 343-LeuSerGlyLysIleAspThrGluLysAspIleLeu-354 364-GlyAlaGluAspValLeu-369 373-PheLysGlyArgLeuAspGly-379 400-ThrAlaArgThrAspGly-405 411-SerAspProAlaAsnGluGlnArgLysLeuVal-421 429-AlaGlyGluGlySerLeu-434 442-LeuPheLysAspArgLeuLeuLysLeuAspIleArgSerArgAlaPheAspProSerArgIleAspPro-46 4 480-GluLeuAlaLysGluLysPheThrGly-488 508-IleValTyrGluSerArgHisLeuPro-516 522-LeuArgLeuGlyArgAεnIleValLyεThrAεpGlyGlyPheGlyLysLysGlyAspArgLeuAsn-543 570-GlyAspLeuAspGlyGlyIleArgThrPheGluThrAspLeuSerGlyThrAla-587 594-LysAlaAlaAspIleArgSer-600 607-GlySerProGlyThrSerArgProMetArgAlaAspI1eLysGlyGlyArg-623 647-HisArgIleArgThr-651 657-LeuAspGlyLysProPheLysLeuAspLeuAεpAla-668 670-GlyGlyIleAεnArgGluLeuThrArgTrpLysGly-681 729-SerTrpAspArgLysThrGlyIleSerAlaLysGlyGlyAlaArg-743 783-SerArgGlnSerGly-787 806-ThrArgPheGlnAsnAspArgIle-813 819-GlyGlyAlaArgPheGlyArgIleAsnAla-828 928-AlaAspAlaGluAlaPhe-933 1001-LeuLysPheArgHisGluGlyThrAlaGluLeu-lOll 1019-AsnSerValProAspValAspIle-1026 1031-AspLysTyrArgIleLeuSerArgProAsnArgArgLeuThr-1044 1049-Thr rgLeuArgTyrSerPro-1055 1065-IleLysThrAspGln-1069 1075-GlnLysSerSerMet-1079 1091-GluValLysLysGluAlaAlaAla-1098 1109-AspLeuAsnAspGlyIleArg-1115 1146-ArgValIleLysGlyArgTyrLysAlaTyrGlyGlnAspLeuAspIleThrLys-1163 1179-IleArgAlaGluArgArgLeuSer-1186 1209-GluProMetSerGluLysAspLysLeu-1217 1225-AlaGlySerGlySerSerGlyAspAsnAlaAla-1235 1248-IleAsnAspArgIleGlyLeu-1254 1259-GlyPheThrSerLysArgSerArgAsnAlaGlnThrGlyGluLeuAsnPro-1275 1300-SerAlaGluGlnSerVal-1305 1321-IleGlySerArgSerSerGlyGly-1328 1340-PheGlySerAspLysLysAspSerAlaGlyAsnGlyLysGlyLys-1354 g286-2 AMPHI Regions - AMPHI 69-GluIleLysAspMetVal-74 102-ProAspAsnValLysThr-107 145-ValAlaIleLeuGlyAsp-150 157-LeuAlaGluTyrTyrArgAsnAlaLeuGluAsnTrpGlnGlnProValGlySer-174 199-LeuAlaLysLeuGlyAεn-204 238-ThrGlnArgTyrProGluGlnThrValSerGlyLeuAlaArgPheGlnProGlyThr-256 326-AspTyrTyrAsnLeuPheAsnLys-333 354-IleSerGlnProArg-358 375-ThrThrGlnAsnLeu-379 428-ThrAlaSerTrpLysArgGlnLeuLeu-436 455-ThrLeuGlyThrPheLeu-460 513-GlyAlaSerSerVal-517 555-LeuSerGlyAlaValPheHisAspMetGlyAspAlaAlaAlaAsn-569 584-ArgTrpPheSerProLeu-589 Antigenic Index - Jameson-Wolf 1-MetHisAspThrArgThrMetMet-δ 30-AlaAspLeuSerGluAsnLysAla-37 43-PheLysSerLysSerProAspThrGluSerValLysLeuLysProLysPheProVal-61 63-IleAspThrGlnAspSerGluIleLysAspMetValGluGluHisLeu-78 83-GlnGlnGlnGluGluValLeuAspLysGluGlnThr-94 97-LeuAlaGluGluAlaProAspAsnValLysThrMetLeuArgSerLysGlyTyrPheSerSerLysValSerL euThrGluLysAspGlyAla-127 133-ThrProGlyProArgThrLysIle-140 151-11eLeuSerAspGlyAsnLeuAlaGluTyrTyrArgAsnAlaLeuGluAsnTrpGln-169 172-ValGlySerAspPheAspGlnAspΞerTrpGluAsnSerLysThrSerVal-188 192-ValThrArgLysGlyTyrPro-198 201-LysLeuGlyAsnThrArgAlaAlaValAsnProAspThrAlaThrAla-216 223-AspSerGlyArgProIleAla-229 234-GluIleThrGlyThrGlnArgTyrProGluGlnThrVal-246 252-PheGlnProGlyThrProTyrAspLeu-260 270-LeuGluGlnAsnGlyHisTyrSerGly-278 283-AlaAspPheAspArgLeuGlnGlyAspArgValProVal-295 298-SerValThrGluValLysArgHisLysLeuGluThrGlyIleArgLeuAspSerGluTyrGlyLeuGlyGly -321 342-AspMetAspLysTyrGluThr-348 355-SerGlnProArgAsnTyrArgGlyAsnTyrTrp-365 368-AsnValSerTyrAsnArgSerThrThrGlnAsnLeuGluLysArgAlaPheSerGlyGly-387 391-ValArgAspArgAlaGlyIleAspAlaArgLeuGly-402 405-PheLeuAlaGluGlyArgLysIleProGlySerAspValAspLeuGlyAsnSerHis-423 430-SerTrpLysArgGlnLeu-435 441-HisProGluAsnGlyHisTyrLeuAspGlyLysIle-452 468-ThrSerAlaArgAlaGly-473 476-PheThrProGluAsnLysLysLeu-483 496-ValAlaArgAspAsnAlaAspValProSer-505 509-PheArgSerGlyGlyAlaSerSerValArgGlyTyrGluLeuAspSer-524 534-ValLeuProGluArgAlaLeu-540 562-AspMetGlyAspAla-566 568-AlaAsnPheLysArgMetLysLeuLysHisGlySerGlyLeu-581 598-TyrGlyHisSerAspLysLys11eArg-606 Hydrophilic Regions - Hopp-Woods 1-MetHisAspThrArgThrMetMet-δ 30-AlaAspLeuSerGluAsnLysAla-37 44-LysSerLysSerProAspThrGluSerValLysLeuLysProLysPheProVal-61 63-IleAspThrGlnAspSerGluIleLysAspMetValGluGluHisLeu-78 84-GlnGlnGluGluValLeuAspLysGluGlnThr-94 97-LeuAlaGluGluAlaProAspAsnValLysThrMetLeuArgSer-lll 119-ValSerLeuThrGluLysAspGlyAla-127 134-ProGlyProArgThrLysIle-140 174-SerAspPheAspGlnAspSerTrpGluAsnSerLysThr-186 192-ValThrArgLysGlyTyrPro-198 206-ArgAlaAlaValAsnProAspThrAlaThr-215 239-GlnArgTyrProGlu-243 283-AlaAspPheAspArgLeuGlnGlyAspArgValProVal-295 298-SerValThrGluValLysArgHisLysLeuGluThrGlyIleArgLeuAspSerGluTyr-317 342-AspMetAspLysTyrGluThr-348 373-ArgSerThrThrGlnAsnLeuGluLysArgAlaPhe-384 392-ArgAspArgAlaGlyI1eAspAlaArgLeuGly-402 405-PheLeuAlaGluGlyArgLysIleProGlySerAspValAspLeu-419 478-ProGluAsnLysLysLeu-483 496-ValAlaArgAspAsnAlaAspVal-503 518-ArgGlyTyrGluLeuAspSer-524 534-ValLeuProGluArgAlaLeu-540 562-AspMetGlyAspAla-566 568-AlaAsnPheLysArgMetLysLeuLysHis-577 600-HisSerAspLysLysIleArg-606 g287 AMPHI Regions - AMPHI 32-AspThrProSerLysPro-37 lll-MetProGlnAsnAlaAlaGluSerAlaAsnGlnThrGly-123 195-LeuSerAspGluGluLysIleLysArgTyrLysLys-206 351-LysSerValAspGlyIleIleAspSer-359 378-GlyPheLysGlyThrTrpThr-384 391-ValSerGlyArgPheTyr-396 Antigenic Index - Jameson-Wolf 18-CysGlyGlyGlyGlyGlyGlySerProAspValLysSerAlaAspThrProSerLysProAla-38 50-ValLeuProLysGluLysLysAspGluGluAlaAlaGlyGlyAlaProGlnAlaAspThrGlnAspAlaThrA laGlyGluGlySerGlnAsp-80 85-SerAlaGluAsnThrGlyAsnGlyGlyAlaAlaThrThrAspAsnProLysAsnGluAspAlaGlyAlaGlnA snAspMetProGlnAsnAlaAlaGluSerAlaAsnGlnThrGlyAsnAsnGlnProAlaGlySerSerAspSerAl aProAlaSerAsnProAlaProAlaAsnGlyGlySerAspPheGlyArgThrAsnValGly-154 160-AspGlyProSerGlnAsn-165 169-ThrHisCysLysGlyAspSerCysAsnGlyAspAsnLeuLeuAspGluGluAlaProSerLysSerGluPhe GluLysLeuSerAspGluGluLysIleLysArgTyrLysLysAspGluGlnArgGluAsnPhe-213 217-ValAlaAspArgValLysLysAspGlyThrAsnLys-228 233-TyrThrAspLysProProThrArgSerAlaArgSerArgArgSerLeuPro-249 262-ThrLeuIleValAspGlyGluAla-269 281-AlaProGluGlyAsnTyrArgTyrLeu-289 292-GlyAlaGluLysLeuProGlyGlySerTyr-301 305-ValGlnGlyGluProAlaLysGlyGluMet-314 329-HisMetGluAsnGlyArgProTyrProSerGlyGlyArgPheAlaAla-344 346-ValAspPheGlySerLysSerValAspGlyIleIleAspSerGlyAspAspLeuHisMetGlyThrGlnLys PheLysAlaAlaIleAspGlyAsnGlyPheLysGlyThrTrpThrGluAsnGlyGlyGlyAspValSerGly-393 395-PheTyrGlyProAlaGlyGluGluValAlaGlyLysTyrSerTyrArgProThrAspAlaGluLysGlyGly Phe-419 423-AlaGlyLysLysAspArgAsp-429 Hydrophilic Regions - Hopp-Woods 22-GlyGlyGlySerProAspValLysSerAlaAspThrProSerLysProAla-38 50-ValLeuProLysGluLysLysAspGluGluAlaAlaGly-62 65-ProGlnAlaAspThrGlnAspAlaThrAlaGlyGluGlySerGlnAsp-80 85-SerAlaGluAsnThrGly-90 95-AlaThrThrAspAsnProLysAsnGluAspAlaGlyAlaGlnAsnAspMetProGlnAsnAlaAlaGluSerA laAsnGln-121 126-GlnProAlaGlySerSerAspSerAlaPro-135 144-GlyGlySerAspPheGlyArg-150 171-CysLysGlyAspSerCysAsnGly-178 180-AsnLeuLeuAspGluGluAlaProSerLysSerGluPheGluLysLeuSerAspGluGluLysIleLysArg TyrLysLysAspGluGlnArgGluAsnPhe-213 217-ValAlaAspArgValLysLysAspGlyThrAsn-227 235-AspLysProProThrArgSerAlaArgSerArgArgSerLeuPro-249 263-LeuIleValAspGlyGluAla-269 292-GlyAlaGluLysLeuPro-297 305-ValGlnGlyGluProAlaLysGlyGluMet-314 331-GluAsnGlyArgProTyrProSer-338 346-ValAspPheGlySerLysSerValAspGlyIleIleAspSerGlyAspAspLeuHis-364 368-GlnLysPheLysAlaAlaIleAsp-375 387-GlyGlyGlyAspValSerGly-393 399-AlaGlyGluGluValAlaGly-405 407-TyrSerTyrArgProThrAspAlaGluLysGlyGly-418 423-AlaGlyLysLysAspArgAsp-429 g288 AMPHI Regions - AMPHI 7-ValSerArgValLeu-ll 54-IleValThrLysCysAla-59 61-ArgProTyrArgThrPheSerProLeuProVal-71 97-HisSerThrLeuArg-101 150-ThrLeuPheGlnAlaGlyPheAsp-157 Antigenic Index - Jameson-Wolf 2-HisThrGlyGlnAla-6 28-AsnLeuProGluArgSerAlaGlySer-36 58-CysAlaValArgProTyrArgThrPheSerPro-68 72-LeuProLysGlnProSerAla-78 89-LeuProArgProAlaValAsnArgHisSerThrLeuArgSerProAspPheProProArgMet-109 113-IleArgGlyAspCysLeuPro-119 126-IleIleThrArgAsnAlaLysMetProSerGluThrValGlnValSerAspGlyIleGlnProLys-147 155-GlyPheAspGluAlaVal-160 Hydrophilic Regions - Hopp-Woods 28-AsnLeuProGluArgSerAla-34 58-CysAlaValArgPro-62 98-SerThrLeuArgSerProAspPheProPro-107 113-IleArgGlyAspCys-117 126-IleIleThrArgAsnAlaLysMetProSerGluThrValGlnVal-140 155-GlyPheAspGluAlaVal-160 g292-2 AMPHI Regions - AMPHI 7-LysIleLeuThrProPheThrValLeuProLeu-17 40-GlyLysSerValAla-44 62-ValLeuSerValSerGlu-67 69-ProValLysGlyIleTyrGlu-75 110-GluArgAlaAlaAspLeu-115 124-ProLeuAspLysAlaIleLysGluValArgGly-134 150-PheCysLysArgLeuGluHisGluPheGluLysMetThrAspValThr-165 195-LysAlaTrpThrAspTrpMetArg-202 212-IleCysAspAsnProVal-217 Antigenic Index - Jameson-Wolf l-MetLysThrLysLeu-5 23-ThrProValSerAsnAlaAsnAlaGluSerAlaValLysAlaGluSerAlaGlyLysSerVal-43 47-LeuLysAlaArgLeuGluLysThrTyrSerAlaGlnAspLeuLys-61 66-SerGluThrProValLysGlyIle-73 85-TyrThrAspAlaGluGlyGlyTyr-92 99-1leAsnl1eAspThrArgLysAsnLeuThrGluGluArgAlaAlaAspLeuAsnLys-117 124-ProLeuAspLysAlaIleLysGluValArgGlyAsnGlyLysLeuLysVal-140 142-ValPheSerAspProAspCysProPhe-150 152-LysArgLeuGluHisGluPheGluLysMetThrAsp-163 177-HisProAspAlaAlaArgLysAla-184 189-CysGlnProAspArgAlaLysAla-196 200-TrpMetArgLysGlyLysPheProVal-208 210-GlySerIleCysAspAsnProValAlaGluThrThrSerLeuGlyGlu-225 238-ProAsnGlyArgThrGlnSerGlyTyrSerPro-248 250-ProGlnLeuGluGluIleIleArgLysAsnGlnGln-261 Hydrophilic Regions - Hopp-Woods l-MetLysThrLysLeu-5 28-AlaAsnAlaGluSerAlaValLysAlaGluSerAlaGlyLysSerVal-43 47-LeuLysAlaArgLeuGluLysThrTyrSer-56 99-IleAsnIleAspThrArgLysAsnLeuThrGluGluArgAlaAlaAspLeuAsnLys-117 124-ProLeuAspLysAlal1eLysGluValArgGlyAsnGlyLysLeuLys-139 144-SerAspProAspCysProPhe-150 152-LysArgLeuGluHisGluPheGluLysMetThrAsp-163 179-AspAlaAlaArgLysAla-184 190-GlnProAspArgAlaLysAla-196 200-TrpMetArgLysGlyLysPhe-206 240-GlyArgThrGlnSer-244 250-ProGlnLeuGluGluIleIleArgLysAsnGlnGln-261 g294-2 AMPHI Regions - AMPHI 27-ArgPheProAlaAlaLeuArgArgTyrSer-36 45-LysProAlaGlyThr-49 51-TrpHisArgValArgArgPheLysSerAsnArgArgThrArgGlyValLysProLeu-69 85-AlaTrpThrAlaLeuSerHisAsnIleAlaGluArgAlaArgGluSerProArgArgCysGlyLysArgTyrA laAspIleGlyGly-113 134-ValAlaHisIleIleHisLeuTyrCys-142 165-ValSerArgGluAlaArgArgGluVal-173 176-AlaMetSerTyrArg-180 212-PheAlaThrSerPheGly-217 227-AlaPheSerValLeuAlaHisPhe-234 247-ThrValGlyTrpSerLysTyrIleHisAlaVal-257 Antigenic Index - Jameson-Wolf 20-AlaValArgThrSerSerAsnArgPhe-28 30-AlaAlaLeuArgArgTyrSerAlaPheArg-39 44-ProLysProAlaGlyThrProTrpHisArgValArgArgPheLysSerAsnArgArgThrArgGlyValLysP roLeuLysLysProTyrLeu-74 76-ArgGlyAlaGluCysArgCysArgArgAla-85 93-IleAlaGluArgAlaArgGluSerProArgArgCysGlyLysArgTyrAlaAspIleGlyGlyAspSerAspT hrIleArgIleArgValPheArgLeuGluHisArgMet-129 161-HisThrGlyArgValSerArgGluAlaArgArgGluValGluLysAlaMetSer-178 240-LysMetAlaArgSer-244 Hydrophilic Regions - Hopp-Woods 20-AlaValArgThrSerSerAsnArg-27 30-AlaAlaLeuArgArg-34 52-HisArgValArgArgPheLysSerAsnArgArgThrArgGlyValLysProLeuLysLys-71 76-ArgGlyAlaGluCysArgCysArgArgAla-85 93-IleAlaGluArgAlaArgGluSerProArgArgCysGlyLysArgTyrAlaAspIleGlyGlyAspSerAspT hrIleArg-119 121-ArgValPheArgLeuGluHisArgMet-129 164-ArgValSerArgGluAlaArgArgGluValGluLysAlaMetSer-178 g295 AMPHI Regions - AMPHI 79-PheArgGlnProArg-83 lll-ValGlnArgPhePheArgGlnPro-118 131-AlaPheLeuHisGlnIle-136 163-ValIleArgLysIleAlaAlaLeu-170 176-AsnLeuArgGlyPhePro-181 189-HisGlnGlnArgArgIleGlyLysThr-197 263-TyrIleIleLysProLeuGluHis-270 Antigenic Index - Jameson-Wolf 4-MetAlaArgHisAspGlyGlnGlnGly-12 18-LeuProArgArgGlnGln-23 36-AlaAlaAlaHisGlyAsnArgProAlaSerAspAlaPhePheLysLeuProArgGlnArgPheHisVal-58 73-HisGlyCysArgAlaGlnPheArgGlnProArgArgIleArgLeuArgLeuArgGlnThrAlaArgGlnArgS erGlyCysGlyThrAspGlnAlaAlaAsp-106 115-PheArgGlnProArgIleArgGlnLysGlnArgHisThrArgSerProAla-131 137-GlyProAspPheGly-141 144-GlnAsnAlaGluHisArgAla-150 171-ArglleGlyLysGlnAsnLeuArgGlyPheProSerArgArgGlyHisLeuArgHisGlnGlnArgArglle GlyLysThrProProGlnLeuAla-202 207-GlyGlyThrArgPheSerAspArgAsnGlyValTyrProAsnArgAlaGlyAsnGlyIleArgMetArgLeu AlaGlu-232 239-ProValCysArgGlyThrSerGly-246 253-ProTyrProTyrArgArgLysGlnProGlnTyr-263 274-SerCysLysThrAsnAlaValArgThrValArgThrAlaPheArgGlnArgAsnGlnIleSer-294 Hydrophilic Regions - Hopp-Woods 5-AlaArgHisAspGlyGlnGln-ll 18-LeuProArgArgGlnGln-23 36-AlaAlaAlaHisGlyAsnArgProAlaSer-45 77-AlaGlnPheArgGlnProArgArgIleArgLeuArgLeuArgGlnThrAlaArgGlnArgSerGlyCysGlyT hrAspGlnAlaAla-105 118-ProArglleArgGlnLysGlnArgHisThrArg-128 146-AlaGluHisArgAla-150 171-ArgIleGlyLysGlnAsnLeu-177 180-PheProSerArgArgGlyHisLeuArgHisGlnGlnArgArgl1eGlyLysThrProPro-199 210-ArgPheSerAspArgAsnGly-216 226-IleArgMetArgLeuAlaGlu-232 239-ProValCysArgGlyThr-244 255-ProTyrArgArgLysGlnPro-261 281-ArgThrValArgThrAlaPheArgGlnArgAsnGlnIle-293 g297 AMPHI Regions - AMPHI 69-GlnProGlyAspSerLeuAlaAspValLeuAla-79 86-AspGluIleAlaArgIleThrGluLysTyr-95 157-LeuProThrLeuArg-161 199-LeuLysGluGlyAspAla-204 272-LeuValTyrThrArgIleSerSer-279 333-HisAlaAsnGlyValGluThrLeuTyrAlaHisLeuSerAlaPheSerGln-349 Antigenic Index - Jameson-Wolf 8-AlaLysHisArgLysTyrAla-14 31-AlaSerThrGluGlyThrGluArgValArgProGlnArgValGluGlnLysLeuPro-49 52-SerTrpGlyGlyAsnGly-57 67-AlaValGlnProGlyAspSerLeuAla-75 78-LeuAlaArgSerGlyMetAlaArgAspGluIleAlaArgIleThrGluLysTyrGlyGlyGluAlaAspLeuA rgHisLeuArgAlaAspGlnSerVal-110 115-GlyGlyAspGlySerAlaArgGlu-122 127-ThrAspGluAspGlyGluArgAsnLeuValAlaLeuGluLysLysGlyGlyIleTrpArgArgSerAlaSer AspAlaAspMetLysVal-156 167-ThrSerAlaArgGlySerLeuAlaArgAlaGluValProValGluIleArgGluSerLeuSer-187 194-PheSerLeuAspGlyLeuLysGluGlyAspAlaVal-205 228-GluValValLysGlyGlyThrThr-235 240-TyrTyrArgSerAspLysGluGlyGlyGlyGlyGlyAsnTyrTyrAspGluAspGlyArgValLeuGlnGlu LysGlyGlyPheAsn-268 276-ArgIleSerSerProPheGlyTyr-283 295-HisThrGlyIleAspTyrAla-301 303-ProGlnGlyThrProValArgAlaSerAlaAspGly-314 318-PheLysGlyArgLysGlyGlyTyrGly-326 333-HisAlaAsnGlyValGlu-338 350-AlaGlnGlyAsnValArgGlyGlyGlu-358 365-SerThrGlyArgSerThrGlyProHisLeu-374 376-TyrGluAlaArgIleAsnGlyGlnProValAsn-386 393-ProThrProGluLeuThrGlnAlaAspLysAlaAla-404 408-GlnLysGlnLysAlaAspAlaLeu-415 426-ValSerGlnSerAsp-430 Hydrophilic Regions - Hopp-Woods 8-AlaLysHisArgLysTyrAla-14 33-ThrGluGlyThrGluArgValArgProGlnArgValGluGlnLysLeu-48 68-ValGlnProGlyAspSerLeuAla-75 82-GlyMetAlaArgAspGluIleAlaArgIleThrGluLysTyrGlyGlyGluAlaAspLeuArgHisLeuArgA laAspGln-108 117-AspGlySerAlaArgGlu-122 127-ThrAspGluAspGlyGluArgAsnLeuValAlaLeuGluLysLysGlyGlyIleTrpArgArgSerAlaSer AspAlaAspMetLysVal-156 167-ThrSerAlaArgGlySerLeuAlaArgAlaGluValProValGluIleArgGluSerLeu-186 194-PheSerLeuAspGlyLeuLysGluGlyAspAlaVal-205 242-ArgSerAspLysGluGlyGlyGly-249 253-TyrTyrAspGluAspGlyArgValLeuGlnGluLysGlyGlyPhe-267 306-ThrProValArgAlaSerAla-312 319-LysGlyArgLysGlyGlyTyr-325 352-GlyAsnValArgGlyGlyGlu-358 366-ThrGlyArgSerThrGly-371 378-AlaArgIleAsnGly-382 396-GluLeuThrGlnAlaAspLysAlaAla-404 408-GlnLysGlnLysAlaAspAlaLeu-415 g298 AMPHI Regions - AMPHI 6-SerLeuPheAlaSerIleLeuMetSerAlaLeuIleAla-18 26-IleAsnAlaTyrTrpGlnGln-32 42-ProLeuAlaAlaTyr-46 62-LeuSerAspGlyIleLysThrPhe-69 134-ValGlnLysSerLeuLys-139 148-AsnLeuSerLysGln-152 157-SerTyrProSerPhePheAspTrpProLysThrIleGluGluThrLeuLysLysHisProGlu-177 188-AsnAspProTrpAsp-192 208-AlaGlnGluTyrLeuLysArgValAspArgIleLeuGlu-220 246-MetArgTyrLeuAspLysLeuLeuSerGluHisLeu-257 276-ArgTyrThrAspSer-280 308-GluLysIleMetGluLys-313 Antigenic Index - Jameson-Wolf 22-SerGlnAsnProIleAsnAlaTyr-29 34-TyrHisArgAsnSerProLeuGluPro-42 47-GlyTrpTrpArgSerGlyAlaAlaLeuGlnGlu-57 70-LeuSerGlyGluThrProProThrAlaGlnAspGlyGlySerAlaAspMetProProGluAlaAlaAlaSerG luAlaAlaProProAlaGlyGlyThrGluTrpLysGlnGlyThrGlu-109 lll-AlaAlaValArgSerGlyAspLysValPhePhe-121 136-LysSerLeuLysGlnGlnTyrGlyIleGluSerAlaAsnLeuSerLysGlnSerThr-154 162-PheAspTrpProLysThrIleGluGluThrLeuLysLysHisProGlu-177 186-GlyProAsnAspProTrp-191 194-ProValGlyLysArgTyrLeu-200 203-AlaSerAspGluTrpAla-208 211-TyrLeuLysArgValAspArgIleLeuGlu-220 238-LysLysValLysLeuAspGlyGlnMetArgTyrLeuAsp-250 252-LeuLeuSerGluHisLeuLysGly-259 269-ThrLeuSerGlyGlyLysGlyArgTyrThrAspSerValAsnValAsnGlyLysProValArgTyrArgSer LysAspGlyIle-296 301-GluGlyGlnLysLeuLeuAla-307 318-ProSerThrGlnProSerSerThrGlnPro-327 Hydrophilic Regions - Hopp-Woods 73-GluThrProProThrAlaGlnAspGlyGlySerAlaAspMetProProGluAlaAlaAlaSerGluAlaAlaP ro-97 102-ThrGluTrpLysGlnGlyThrGlu-109 lll-AlaAlaValArgSerGlyAsp-117 148-AsnLeuSerLysGlnSerThr-154 166-LysThrIleGluGluThrLeuLysLysHisProGlu-177 211-TyrLeuLysArgValAspArgIleLeuGlu-220 238-LysLysValLysLeuAspGlyGlnMetArgTyrLeuAsp-250 252-LeuLeuSerGluHisLeuLysGly-259 271-SerGlyGlyLysGlyArgTyrThrAsp-279 281-ValAsnValAsnGlyLysProValArgTyrArgSerLysAspGlyIle-296 301-GluGlyGlnLysLeuLeuAla-307 319-SerThrGlnProSerSerThrGlnPro-327 g299 AMPHI Regions - AMPHI 1-MetAsnProLysHisPheIleAlaPheSerAlaLeuPheAlaAlaThrGlnAlaGluAlaLeuProValAlaSe rValSerProAspThrValThrValSerProSerAlaProTyrThrAspThrAsnGlyLeuLeuThrAspTyrGly AsnAlaAlaAlaSerProTrpMetLysLysLeuArgSerValAlaGlnGlySerGlyGluAlaPheArglleLeuG lnlleGlyAspSerHisThrAlaGlyAspPhePheThrAspAlaLeuArgLysArgLeuGlnLysThrTrpGlyAs pGlyGlylleGlyTrpValTyrProAlaAsnValLysGlyGlnArgMetAlaAlaValArgHisSerGlyAsnTrp GlnSerPheThrSerArgAsnAsnThrGlyAspPheProLeuGlyGlylleLeuAlaGlnThrGlySerGlyGlyG lyMetThrLeuThrAlaSerAspGlyLysThrGlyLysGlnArgValSerLeuPheAlaLysProLeuLeuAlaGl uGlnThrLeuThrValAsnGlyAsnThrValSerAlaAsnGlyGlyGlyTrpGlnValLeuAspThrGlyAlaAla LeuProLeuAlalleGlnThrGluMetProTrpAspIleGlyPhelleAsnlleGluAsnProAlaGlyGlylleT hrValSerAlaMetGlylleAsnGlyAlaGlnLeuThrGlnTrpSerLysTrpArgAlaAspArgMetAsnAspLe uAlaGlnThrGlyAlaAspLeuVallleLeuSerTyrGlyThrAsnGluAlaPheAsnAsnAsnlleAspIleAla AspThrGluGlnLysTrpLeuAspThrValArgGlnlleArgAspSerLeuProAlaAlaGlylleLeuIlelleG lyAlaProGluSerLeuLysAsnThrLeuGlyValCysGlyThrArgProValLeuLeuThrGluValGlnGlnMe tGlnArgArgValAlaArgGlnGlyGlnThrMetPheTrpSerTrpGlnAsnAlaMetGlyGlylleCysSerMet LysAsnTrpLeuAsnGlnGlyTrpAlaAlaLysAspGlyValHisPheSerAlaGlnGlyTyrArgArgAlaAlaG luMetLeuAlaAspSerLeuGluGluLeuValArgAlaAlaAlaIleArgGln-397 Antigenic Index - Jameson-Wolf 1-MetAsnProLysHisPheIleAlaPheSerAlaLeuPheAlaAlaThrGlnAlaGluAlaLeuProValAlaSe rValSerProAspThrValThrValSerProSerAlaProTyrThrAspThrAsnGlyLeuLeuThrAspTyrGly AsnAlaAlaAlaSerProTrpMetLysLysLeuArgSerValAlaGlnGlySerGlyGluAlaPheArglleLeuG lnlleGlyAspSerHisThrAlaGlyAspPhePheThrAspAlaLeuArgLysArgLeuGlnLysThrTrpGlyAs pGlyGlylleGlyTrpValTyrProAlaAsnValLysGlyGlnArgMetAlaAlaValArgHisSerGlyAsnTrp GlnSerPheThrSerArgAsnAsnThrGlyAspPheProLeuGlyGlylleLeuAlaGlnThrGlySerGlyGlyG lyMetThrLeuThrAlaSerAspGlyLysThrGlyLysGlnArgValSerLeuPheAlaLysProLeuLeuAlaGl uGlnThrLeuThrValAsnGlyAsnThrValSerAlaAsnGlyGlyGlyTrpGlnValLeuAspThrGlyAlaAla LeuProLeuAlalleGlnThrGluMetProTrpAspIleGlyPhelleAsnlleGluAsnProAlaGlyGlylleT hrValSerAlaMetGlylleAsnGlyAlaGlnLeuThrGlnTrpSerLysTrpArgAlaAspArgMetAsnAspLe uAlaGlnThrGlyAlaAspLeuVallleLeuSerTyrGlyThrAsnGluAlaPheAsnAsnAsnlleAspIleAla AspThrGluGlnLysTrpLeuAspThrValArgGlnlleArgAspSerLeuProAlaAlaGlylleLeuIlelleG lyAlaProGluSerLeuLysAsnThrLeuGlyValCysGlyThrArgProValLeuLeuThrGluValGlnGlnMe tGlnArgArgValAlaArgGlnGlyGlnThrMetPheTrpSerTrpGlnAsnAlaMetGlyGlylleCysSerMet LysAsnTrpLeuAsnGlnGlyTrpAlaAlaLysAspGlyValHisPheSerAlaGlnGlyTyrArgArgAlaAlaG luMetLeuAlaAspSerLeuGluGluLeuValArgAlaAlaAlaIleArgGln-397 Hydrophilic Regions - Hopp-Woods 1-MetAsnProLysHisPheIleAlaPheSerAlaLeuPheAlaAlaThrGlnAlaGluAlaLeuProValAlaSe rValSerProAspThrValThrValSerProSerAlaProTyrThrAspThrAsnGlyLeuLeuThrAspTyrGly AsnAlaAlaAlaSerProTrpMetLysLysLeuArgSerValAlaGlnGlySerGlyGluAlaPheArglleLeuG lnlleGlyAspSerHisThrAlaGlyAspPhePheThrAspAlaLeuArgLysArgLeuGlnLysThrTrpGlyAs pGlyGlylleGlyTrpValTyrProAlaAsnValLysGlyGlnArgMetAlaAlaValArgHisSerGlyAsnTrp GlnSerPheThrSerArgAsnAsnThrGlyAspPheProLeuGlyGlylleLeuAlaGlnThrGlySerGlyGlyG lyMetThrLeuThrAlaSerAspGlyLysThrGlyLysGlnArgValSerLeuPheAlaLysProLeuLeuAlaGl uGlnThrLeuThrValAsnGlyAsnThrValΞerAlaAsnGlyGlyGlyTrpGlnValLeuAspThrGlyAlaAla LeuProLeuAlalleGlnThrGluMetProTrpAspIleGlyPhelleAsnlleGluAsnProAlaGlyGlylleT hrValSerAlaMetGlylleAsnGlyAlaGlnLeuThrGlnTrpSerLysTrpArgAlaAspArgMetAsnAspLe uAlaGlnThrGlyAlaAspLeuVallleLeuSerTyrGlyThrAsnGluAlaPheAsnAsnAsnlleAspIleAla AspThrGluGlnLysTrpLeuAspThrValArgGlnlleArgAspSerLeuProAlaAlaGlylleLeuIlelleG lyAlaProGluSerLeuLysAsnThrLeuGlyValCysGlyThrArgProValLeuLeuThrGluValGlnGlnMe tGlnArgArgValAlaArgGlnGlyGlnThrMetPheTrpSerTrpGlnAsnAlaMetGlyGlylleCysSerMet LysAsnTrpLeuAsnGlnGlyTrpAlaAlaLysAspGlyValHisPheSerAlaGlnGlyTyrArgArgAlaAlaG luMetLeuAlaAspSerLeuGluGluLeuValArgAlaAlaAlaIleArgGln-397 g302 AMPHI Regions - AMPHI 20-SerGlyArgPheLeuArgThrValGluTrpLeuGlyAsnMetLeuProHisPro-37 81-ValValSerLeuLeuAspAlaAspGlyLeuIleLysIleLeuThrHisThrValLysAsnPheThrGlyPheA laProLeuGlyThrValLeuValSerLeu-114 127-SerAlaLeuMetArg-131 171-IlePheHisSerLeuGlyArgHisProLeuAlaGlyLeuAlaAlaAlaPheAlaGlyValSerGly-192 201-GlyThrIleAspProLeuLeuAlaGlyIleThrGlnGlnAla-214 240-IleAlaLeuIleGly-244 271-ArgHisSerAsnGluIle-276 294-LeuSerAlaLeuLeuAlaTrp-300 308-IleLeuArgHisProGluThr-314 341-TyrGlyArgIleThrArgSerLeuArgGly-350 352-ArgGluValValAsnAlaMetAlaGluSerMetSer-363 378-PheValAlaPhePheAsnTrpThrAsnIleGlyGlnTyrIle-391 448-AlaProGlnValIle-452 455-AlaTyrArgIleGlyAspSerValThrAsnIleIleThrProMetMetSerTyrPheGlyLeuIleMetAla -478 505-IleAlaTrpIleAlaLeuPheCysIle-513 Antigenic Index - Jameson-Wolf 8-LysGluLysGlnMetSerGlnThrAspAlaArgArgSerGlyArgPheLeuArg-25 61-SerValProAspProArgProValGlyAlaLysGlyArgAlaAspAspGlyLeu-78 85-LeuAspAlaAspGlyLeu-90 119-IleAlaGluLysSerGly-124 134-LeuThrLysSerProArgLysLeuThr-142 152-LeuSerAsnThrAlaSerGlu-158 175-LeuGlyArgHisProLeu-180 250-LysIleValGluProGlnLeuGlyProTyrGlnSerAspLeuSerGlnGluGluLysAspIleArgHisSer AsnGluIleThrProLeuGluTyrLys-282 304-ProAlaAspGlyIleLeuArgHisProGluThrGlyLeu-316 343-ArgIleThrArgSerLeuArgGlyGluArgGluValVal-355 402-ValGlyLeuGlyGly-406 482-LysTyrLysLysAspAlaGlyVal-489 Hydrophilic Regions - Hopp-Woods 8-LysGluLysGlnMetSerGlnThrAspAlaArgArgSerGlyArgPhe-23 63-ProAspProArgProValGlyAlaLysGlyArgAlaAspAspGlyLeu-78 85-LeuAspAlaAspGlyLeu-90 119-IleAlaGluLysSerGly-124 136-LysSerProArgLysLeu-141 263-LeuSerGlnGluGluLysAspIleArgHisSerAsnGlu-275 307-GlyIleLeuArgHisProGlu-313 344-IleThrArgSerLeuArgGlyGluArgGluValVal-355 482-LysTyrLysLysAspAlaGly-488 g305 AMPHI Regions - AMPHI 10-LeuMetMetGlyLeuValGluGlyPheThrGluPheLeuPro-23 33-PheGlyAsnLeuIleGly-38 66-PheSerAsnValLeuHis-71 93-AlaAlaValMetGly-97 99-LeuPheAspLysGlnIleLysGluTyrLeuPhe-109 141-AspValAspAlaLeuArgProIleAspAla-150 155-ValAlaGlnValPheAla-160 202-AlaTyrAspValLeuLysHisTyrArgPhePheThrLeuHis-215 222-IleGlyPheIleAlaAlaPheValSer-230 235-ValLysAlaLeuLeuLys-240 Antigenic Index - Jameson-Wolf 41-SerAsnHisLysValPhe-46 61-GluTyrArgGlnArgPheSerAsn-68 72-GlyValGlyLysAspArgLysAlaAsn-80 128-ValGluLysArgGlnSerArgAlaGluProLysIleAlaAsp-141 143-AspAlaLeuArgProIleAsp-149 163-ProGlyThrSerArgSerGlySerThr-171 180-IleGluArgLysThrAlaThr-186 241-PheValSerLysLysAsnTyr-247 Hydrophilic Regions - Hopp-Woods 62-TyrArgGlnArgPhe-66 73-ValGlyLysAspArgLysAlaAsn-80 128-ValGluLysArgGlnSerArgAlaGluProLysIleAlaAsp-141 143-AspAlaLeuArgProIleAsp-149 165-ThrSerArgSerGlySer-170 180-IleGluArgLysThrAlaThr-186 242-ValSerLysLysAsn-246 g308-l AMPHI Regions - AMPHI 6-PheTyrArgIleLeuGlyValAlaAsp-14 27-ThrIleIleAlaGlyLeu-32 64-AlaLeuGluLeuLeuArgAlaGln-71 83-AlaGluMetAlaArgAlaSerGlu-90 101-LeuAlaAspPheValHisProIleGlyAsnIleGlyAlaCys-114 131-SerMetArgThrLeuAlaSerValAlaHisGlyPheGlyAsp-144 172-LeuAlaHisLeuAspAsnMetLysArgValThrGlu-183 Antigenic Index - Jameson-Wolf 39-TrpGluArgArgMetMetVal-45 68-LeuArgAlaGlnAspValGluThr-75 80-SerLysGlyAlaGluMetAlaArgAlaSerGluThrAspTyrThrLysAspGluVal-98 118-GlyThrPheLysThrAspGlyMet-125 141-GlyPheGlyAspAsnLeuLeu-147 149-ArgAlaAlaAspValValLeuLysGluArgArgArgLeu-161 166-ArgGluThrProLeu-170 176-AspAsnMetLysArgValThrGluMetGly-185 195-MetTyrArgLysProGlnThrAlaAspAspIleVal-206 220-AspThrProAspLeuAlaGlu-226 Hydrophilic Regions - Hopp-Woods 39-TrpGluArgArgMetMetVal-45 68-LeuArgAlaGlnAspValGluThr-75 81-LysGlyAlaGluMetAlaArgAlaSerGluThrAspTyrThrLysAspGluVal-98 120-PheLysThrAspGly-124 149-ArgAlaAlaAspValValLeuLysGluArgArgArgLeu-161 176-AspAsnMetLysArgValThrGlu-183 195-MetTyrArgLysProGlnThrAlaAspAspIleVal-206 g311-l AMPHI Regions - AMPHI 7-SerHisTrpArgValLeuAlaGluLeuAlaAspGlyLeuProGlnHisValSerGlnLeuAlaArg-28 37-LeuAsnGlyPheTrpGlnGlnMetProAlaHisIleArgGlyLeuLeuArg-53 55-HisAspGlyTyrTrpArgLeuValArgProLeuAlaValPheAspAlaGluGlyLeuArgAspLeuGly-77 124-ArgGlnGlyArgLysTrpSerHisArgLeu-133 155-LeuSerProValAlaAla-160 219-ValGluAsnAlaAlaSerValGlnSerLeuPheGln-230 245-GluThrLeuLeuAlaGluLeuGlyAlaValLeuGluGlnTyrAlaGluGlu-261 265-ProPheLeuAsnGlu-269 291-CysGluGlyThrVal-295 362-ThrValGlySerAlaProTyrArgAspLeuSerProLeu-374 426-TyrArgHisProGluGluHisGlySerAspArgTrpPheAsnAlaLeuGlySer-443 511-AlaValAlaSerGlyMetMetAspAlaValCysGly-522 550-AlaAlaLysValAlaGluAlaLeuProPro-559 576-HisGlyLeuLeuAsnLeu-581 Antigenic Index - Jameson-Wolf 26-LeuAlaArgGluAlaAspMetLysProGlnGln-36 50-GlyLeuLeuArgGlnHisAspGlyTyr-58 71-GluGlyLeuArgAspLeuGlyGluArgSerGlyPheGlnThr-84 86-LeuLysHisGluCysAlaSerSerAsnAspGluIleLeuGlu-99 102-ArgIleAlaProAspLysAlaHisLys-llO 116-HisLeuGlnSerLysGlyArgGlyArgGlnGlyArgLysTrpSerHisArgLeuGlyGlu-135 145-PheAspArgProGlnTyrGluLeuGlySer-154 162-AlaCysArgArgAlaLeuGly-168 174-ThrGlnIleLysTrpProAsn-180 182-LeuValValGlyArgAspLysLeuGly-190 196-ThrValArgAlaGlyGlyLysThrVal-204 215-LeuProLysGluValGluAsn-221 231-ThrAlaSerArgArgGlyAsnAlaAsp-239 257-GlnTyrAlaGluGluGlyPhe-263 269-GluTyrGluThrAlaAsnArgAspHisGlyLys-279 283-LeuLeuArgAspGlyGluThrValCysGluGlyThrValLysGlyValAspGlyArgGlyValLeu-304 307-GluThrAlaGluGlyGluGlnThrValValSerGlyGluIleSerLeuArgProAspAsnArgSerValSer ValProLysArgProAspSerGluArgPheLeu-341 344-GluGlyGlyAsnSerArgLeuLys-351 364-GlySerAlaProTyrArgAspLeuSerProLeuGly-375 378-TrpAlaGluLysAlaAspGlyAsnValArgIle-388 394-CysGlyGluSerLysLysAlaGlnValLysGluGlnLeuAlaArgLysIleGlu-411 424-AsnHisTyrArgHisProGluGluHisGlySerAspArgTrp-437 440-AlaLeuGlySerArgArgPheSerArgAsnAla-450 464-AlaLeuThrAspAspGlyHisTyrLeuGly-473 483-MetLysGluSerLeuAla-488 492-AlaAsnLeuAsnArgProAlaGlyLysArgTyrPro-503 529-GlyArgLeuLysGluLysAsnGlyAlaGlyLysProVal-541 547-GlyGlyGlyAlaAlaLysValAlaGlu-555 565-AsnThrValArgValAlaAsp-571 584-AlaGluGlyGlyGluSerGluHisAla-592 Hydrophilic Regions - Hopp-Woods 26-LeuAlaArgGluAlaAspMetLysProGlnGln-36 50-GlyLeuLeuArgGlnHis-55 71-GluGlyLeuArgAspLeuGlyGluArgSerGlyPhe-82 86-LeuLysHisGluCysAlaSerSerAsnAspGluIleLeuGlu-99 102-ArgIleAlaProAspLysAlaHisLys-llO 118-GlnSerLysGlyArgGlyArgGlnGlyArgLysTrpSerHisArgLeuGlyGlu-135 162-AlaCysArgArgAlaLeu-167 183-ValValGlyArgAspLysLeuGly-190 196-ThrValArgAlaGlyGlyLys-202 217-LysGluValGluAsn-221 232-AlaSerArgArgGlyAsnAlaAsp-239 257-GlnTyrAlaGluGluGlyPhe-263 270-TyrGluThrAlaAsnArgAspHisGlyLys-279 285-ArgAspGlyGluThrValCys-291 293-GlyThrValLysGlyValAspGlyArgGly-302 307-GluThrAlaGluGlyGluGlnThrValVal-316 320-IleSerLeuArgProAspAsnArgSerValSerValProLysArgProAspSerGluArg-339 346-GlyAsnSerArgLeu-350 367-ProTyrArgAspLeuSer-372 378-TrpAlaGluLysAlaAspGlyAsnVal-386 395-GlyGluSerLysLysAlaGlnValLysGluGlnLeuAlaArgLysIleGlu-411 424-AsnHisTyrArgHisProGluGluHisGlySer-434 442-GlySerArgArgPheSerArg-448 464-AlaLeuThrAspAspGlyHis-470 483-MetLysGluSerLeuAla-488 493-AsnLeuAsnArgProAlaGlyLysArgTyrPro-503 529-GlyArgLeuLysGluLysAsnGlyAlaGlyLysProVal-541 549-GlyAlaAlaLysValAlaGlu-555 565-AsnThrValArgValAlaAsp-571 585-GluGlyGlyGluSerGluHisAla-592 g312 AMPHI Regions - AMPHI 6-GlyGluIleLeuGluThrValLysMetValAlaAsp-17 44-GlnAsnIleTyrAsnLysIleThrThrValGlyLys-55 82-IleAlaGlnIleAlaAlaAlaThr-89 96-SerValAlaGlnThrLeuAspLysAlaAlaLys-106 109-GlyValSerPheIleGlyGlyPheSerAlaLeuValGln-121 133-ArgSerValProGluAlaMetLysThr-141 167-GlyGluThrIleLysArgThrAlaGluIle-176 182-GlyCysAlaLysIleValValPheCys-190 230-SerAspAlaValSerLeuThrGluValAlaGluValValLysLys-244 249-IleThrArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 281-ValGlyAspSerValAlaArgIleLeuGluGluMetGly-293 309-LeuAsnAspAlaVal-313 322-SerAlaValGlyGlyLeuSerGly-329 349-LeuThrLeuAspLysLeuGluAlaMetThrAla-359 374-ThrProAlaHisThrIleSerGlyIleIle-383 409-ValGlyAspSerValGluPheGlyGlyLeuLeuGly-420 Antigenic Index - Jameson-Wolf 4-GlnSerGlyGluIleLeuGlu-10 13-LysMetValAlaAspArgAsnPheAspVal-22 35-IleSerThrAspIleAspVal-41 52-ThrValGlyLysAspLeuValAla-59 64-LeuSerAlaLysTyr-68 89-ThrLysAlaAspSerTyrVal-95 100-ThrLeuAspLysAlaAlaLys-106 121-GlnLysGlyMetSerProSerAspGluValLeu-131 134-SerValProGluAlaMetLysThrThrAsp-143 152-GlySerThrArgAla-156 161-AspAlaValLysLeuAlaGlyGluThrIleLysArgThrAlaGluIleThrProGluGlyPheGly-182 192-AlaValGluAspAsnProPhe-198 204-HisGlySerGlyGluAlaAspAla-211 225-AlaAlaLeuGluAsnSerAspAla-232 237-GluValAlaGluValValLys-243 251-ArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 280-AlaValGlyAspSerValAlaArgIleLeuGlu-290 311-AspAlaValLysLysGlyGlyMet-318 334-ValSerGluAspGluGlyMet-340 352-AspLysLeuGluAla-356 370-ValProGlyAspThrProAla-376 383-IleAlaAspGluAlaAla-388 392-IleAsnSerLysThrThrAla-398 405-ThrGlyLysThrValGlyAspSerValGlu-414 426-ProAlaLysGluGlySerCys-432 435-PheValAsnArgGlyGlyArgIle-442 447-GlnSerMetLysAsn-451 Hydrophilic Regions - Hopp-Woods 13-LysMetVa1AlaAspArgAsnPheAspVa1-22 35-IleSerThrAspIleAspVal-41 52-ThrValGlyLysAspLeuValAla-59 89-ThrLysAlaAspSer-93 100-ThrLeuAspLysAlaAlaLys-106 123-GlyMetSerProSerAspGluValLeu-131 134-SerValProGluAlaMetLysThrThrAsp-143 161-AspAlaValLysLeuAlaGlyGluThrIleLysArgThrAlaGluIleThrPro-178 192-AlaValGluAspAsnPro-197 207-GlyGluAlaAspAla-211 225-AlaAlaLeuGluAsnSerAspAla-232 237-GluValAlaGluValValLys-243 251-ArgValGlyGluLeuIleGlyArgGluAlaSerLys-262 284-SerValAlaArgIleLeuGlu-290 311-AspAlaValLysLysGlyGlyMet-318 334-ValSerGluAspGluGlyMet-340 352-AspLysLeuGluAla-356 383-IleAlaAspGluAlaAla-388 408-ThrValGlyAspSerValGlu-414 426-ProAlaLysGluGlySerCys-432 438-ArgGlyGlyArgIle-442 447-GlnSerMetLysAsn-451 g313-2 AMPHI Regions - AMPHI 27-GlyMetAspAspProArgThrTyrGlySerGly-37 41-AlaThrAsnValLeu-45 60-AspAlaAlaLysGly-64 66-ValAlaValLeuLeuAlaArgValLeuGlnGluPro-77 88-ValAlaLeuAlaAlaLeuValGlyHisMetTrpPro-99 143-SerLeuAlaAlaLeuValAla-149 Antigenic Index - Jameson-Wolf 26-TyrGlyMetAspAspProArgThrTyrGlySerGlyAsnProGlyAla-41 46-ArgSerGlyLysLysLysAlaAla-53 73-ValLeuGlnGluProLeuGlyLeuSerAspSerAla-84 104-PheLysGlyGlyLysGlyVal-llO 180-ArgHisLysSerAsn-184 189-IleLysGlyLysGluSerLysIleGlyGluLysArg-200 Hydrophilic Regions - Hopp-Woods 26-TyrGlyMetAspAspProArgThrTyrGly-35 46-ArgSerGlyLysLysLysAlaAla-53 105-LysGlyGlyLysGlyVal-llO 189-IleLysGlyLysGluSerLysIleGlyGluLysArg-200 g401 AMPHI Regions - AMPHI 46-ValLysProTyrAsnAlaLeu-52 65-CysTyrAsnCysHisSerGlnMetIleArgProPheArg-77 112-ValGlyGlyArgTyrSerAspGluTrpHisArgIle-123 157-MetLysAlaLeuArgLysValGlyThr-165 172-IleAlaLysAlaProGluAlaLeu-179 Antigenic Index - Jameson-Wolf 5-GlnLeuAlaGluGluLysIle-ll 38-AlaAlaThrGlnProAlaProGlyValLysProTyrAsn-50 55-AlaGlyArgAspIleTyrIleArgGluGlyCysTyrAsnCysHis-69 74-ArgProPheArgAlaGluThrGluArgTyrGlyHis-85 90-GlyGluSerValTyr-94 98-PheGlnTrpGlySerLysArgThrGlyProAspLeuAlaArgValGlyGlyArgTyrSerAspGluTrpHis- 121 125-LeuLeuAsnProArgAspValValProGluSerAsnMetPro-138 146-AsnLysValAspValAspAla-152 158-LysAlaLeuArgLysValGlyThrProTyrSerAspGluGluIleAlaLysAlaProGlu-177 179-LeuAlaAsnLysSerGluLeuAspAla-187 Hydrophilic Regions - Hopp-Woods 5-GlnLeuAlaGluGluLysIle-ll 76-PheArgAlaGluThrGluArgTyrGly-84 101-GlySerLysArgThrGlyProAspLeuAlaArgValGlyGlyArgTyrSerAspGluTrpHis-121 127-AsnProArgAspValValPro-133 146-AsnLysValAspValAspAla-152 158-LysAlaLeuArgLysValGly-164 167-TyrSerAspGluGluIleAlaLysAlaProGlu-177 179-LeuAlaAsnLysSerGluLeuAspAla-187 g402 AMPHI Regions - AMPHI 13-IleAsnMetLeuSerPheLeuThrGly-21 44-GlnAlaPheSerPheIle-49 85-AlaGlyIleAlaAspPhe-90 100-ThrGlyPheSerGlyPheValHis-107 117-AlaValValArgGlyLeu-122 136-LysSerGlyArgGln-140 146-PheAlaAsnValAlaGly-151 218-ValPheGlnAsnIleAlaGlyArgProAsp-227 261-AspIlePheAsnSerValAsnGlyIleGlu-270 279-LysSerGlyIleArg-283 294-SerTrpAlaArgValLeuSerAlaIleProGluMetGln-306 344-ArgLysTrpLeuArgArgHisPro-351 376-AlaGluPheLeuLysGlnValGlnSerHisLeu-386 398-HisSerProHisAlaPheAlaThrAlaValHisSerIlePro-411 437-GlnArgLeuSerArgLeu-442 460-AlaAlaGlnLysVal-464 466-SerArgMetLeuIleArgMet-472 Antigenic Index - Jameson-Wolf 4-ValAsnThrLysProAsnThrSer-ll 66-ArglleCysArgSerArgPheValAsp-74 130-ValGlyThrAspGlyAsnLysSerGlyArgGlnValSer-142 223-AlaGlyArgProAspArgLeuIleGluAsnLysHisGly-235 240-TyrHisArgAspGlyAspLysValVal-248 264-AsnSerValAsnGlyIleGluArg-271 277-SerLeuLysSerGlyIleArgArg-284 321-IleAlaAspGluProGln-326 331-LeuGlnAspLysArgValGluIleValLeuAspAspGlyArgLysTrpLeuArgArgHisProAspGluLys PheAsp-356 385-HisLeuThrProAspGly-390 429-PheProAsnLysGluLeuLeuLysGlnArgLeuSer-440 444-TrpProGluSerGlyArgHisValPheAspSerSerThrVal-457 472-MetThrGluProSerAlaGly-478 481-ValIleThrAspAspAsnMet-487 489-ValGluTyrLysTyrGlyArgGlyIle-497 Hydrophilic Regions - Hopp-Woods 4-ValAsnThrLysProAsn-9 131-GlyThrAspGlyAsnLysSerGlyArgGlnVal-141 223-AlaGlyArgProAspArgLeuIleGluAsnLysHis-234 241-HisArgAspGlyAspLysValVal-248 278-LeuLysSerGlyIleArg-283 321-IleAlaAspGluProGln-326 331-LeuGlnAspLysArgValGluIleValLeuAspAspGlyArgLysTrpLeuArgArgHisProAspGluLys PheAsp-356 430-ProAsnLysGluLeuLeuLysGlnArgLeuSer-440 446-GluSerGlyArgHisValPhe-452 472-MetThrGluProSerAlaGly-478 481-ValIleThrAspAspAsnMet-487 g501 AMPHI Regions - AMPHI 63-ValGluValLeuGlnGluLeuPheArgGlnTyrArgValAlaArgGlnLeu-79 88-ValPheAlaAlaPheGlnAlaValPhePheGlnCysLeuAsnHisCysPheGly-105 127-AsnAlaPheGlnGly-131 139-ValPheGluAlaLeuGlyAsnIleThrArgArgThrThrGluAla-153 183-AspGlyPheThrArgIleAsnArgCysGlyLysArgCysHisAlaPheGlyAspPheIleAsp-203 253-AlaPheAlaGlyGlnIle-258 307-TyrGlyAsnPheLeuThrValPheGlnGluPheGlyArgIleAlaAlaAlaAsp-324 365-GlyAsnGlnTyrValAlaGlyPhe-372 492-GlyGluAsnHisPheAspValPheArgThr-501 513-PheGluArgGlyPheGluHisIleLysPheValArgValAspArgAlaLeuTyrAspValPheAlaGlnThr -536 Antigenic Index - Jameson-Wolf 6-LeuThrAlaAspThrAspIle-12 19-GlyGlyAspGlyLysMetGlnHisHisPheAspGly-30 46-ValGluAlaGluGlyGln-51 56-ValArgAlaAspGlyGluAlaValGluVal-65 108-GlnSerAlaAspGluArgAsnHisAspPheAspValGlyGln-121 145-AsnIleThrArgArgThrThrGluAlaGlnHis-155 179-GlyHisThrAspAspGlyPheThrArgIleAsnArgCysGlyLysArgCysHisAla-197 202-IleAspValGluValAspArgGlyCysValThrGlyAspAlaAlaAspAsnPhe-219 231-GlnGlnGlyPheArgValAspAlaAspLeuAlaValAspAspLysPheHisThrArgGlnAlaAsp-252 258-IleGlyGluAlaGluCysGluPheGly-266 270-ValHisHisAspPheAspGlyCys-277 283-GlnGlyAspIleGly-287 295-GlyIleAspLysAlaGly-300 321-AlaAlaAlaAspAspGlyArgAsnThrGlnPheAlaArgAspAspGlyGlyValAla-339 345-ValGlyHisAspGlyGlySerThr-352 392-LeuThrAspGlyThr-396 398-PheAlaGlnAspGly-402 421-PheAspGlyPheGly-425 442-PheAspIleHisArg-446 453-AspGlyGlnArgVal-457 479-PheAspValGlyTyr-483 502-HisGlyLeuAlaGlnAspGlyGly-509 523-ValArgValAspArgAlaLeu-529 536-ThrValArgGlyGlyAsnLysAspAspLeuVal-546 552-ValGluGlyGluHisHisThr-558 Hydrophilic Regions - Hopp-Woods 6-LeuThrAlaAspThr-10 19-GlyGlyAspGlyLysMet-24 46-ValGluAlaGluGlyGln-51 56-ValArgAlaAspGlyGluAlaValGluVal-65 108-GlnSerAlaAspGluArgAsnHisAspPheAspVal-119 146-IleThrArgArgThrThrGluAlaGlnHis-155 179-GlyHisThrAspAspGlyPheThrArgIleAsnArgCysGlyLysArgCysHisAla-197 202-IleAspValGluValAspArgGlyCysVal-211 214-AspAlaAlaAspAsnPhe-219 234-PheArgValAspAlaAspLeuAlaValAspAspLysPheHisThrArgGlnAlaAsp-252 258-IleGlyGluAlaGluCysGluPheGly-266 270-ValHisHisAspPhe-274 295-GlyIleAspLysAlaGly-300 321-AlaAlaAlaAspAspGlyArgAsnThrGlnPheAlaArgAspAspGlyGlyVal-338 345-ValGlyHisAspGly-349 523-ValArgValAspArgAlaLeu-529 537-ValArgGlyGlyAsnLysAspAspLeuVal-546 552-ValGluGlyGluHisHisThr-558 g502-l AMPHI Regions - AMPHI 6-AsnLeuPheGlnPheLeuAlaValCys-14 26-GlyAlaValAspAlaLeuLysGlnPheAsnAsnAspAlaAspGlyIleSerGlySerPheThrGln-47 98-GlnValThrLysSerSerGlnAsp-105 136-GlyIleAspTyrVal-140 Antigenic Index - Jameson-Wolf 32-LysGlnPheAsnAsnAspAlaAspGlyIleSerGlySer-44 48-ThrValGlnSerLysLysLysThrGlnThrAlaHisGlyThr-61 98-GlnValThrLysSerSerGlnAspGlnAlaIleGlyGlySerPro-112 116-LeuSerAsnLysThrAlaLeuGluSerSerTyrThrLeuLysGluAspGlySerSerAsnGly-136 141-ArgAlaThrProLysArgAsnAsnAlaGly-150 158-PheLysGlyGlyAsn-162 167-GlnLeuLysAspSerPheGlyAsnGlnThr-176 184-AsnThrAsnProGlnLeuSerArgGlyAlaPhe-194 196-PheThrProProLysGlyValAspVal-204 Hydrophilic Regions - Hopp-Woods 34-PheAsnAsnAspAlaAspGlylle-41 49-ValGlnSerLysLysLysThrGlnThr-57 100-ThrLysSerSerGlnAspGlnAlaIle-108 126-TyrThrLeuLysGluAspGlySerSerAsn-135 141-ArgAlaThrProLysArgAsnAsnAla-149 167-GlnLeuLysAspSerPheGly-173 g503-l AMPHI Regions - AMPHI 6-TyrArgGluAlaLys-10 95-ThrSerSerThrSerAsnPheAlaArgAlaAlaGluMetArgSerPhe-110 Antigenic Index - Jameson-Wolf 4-SerLeuTyrArgGluAlaLysThr-11 32-ProAlaAsnAspAlaSerGlyArgSerSerAlaValAlaGluGluArgThrAlaThrGluMetSerAlaProS er-56 69-SerAlaSerSerCysSerGlyLysGlyValSer-79 87-LeuProThrArgAlaSerSerGluThrSerSerThrSerAsnPhe-101 103-ArgAlaAlaGluMetArgSerPheArgProLeuCysAlaArgAsnAlaArg-119 Hydrophilic Regions - Hopp-Woods 4-SerLeuTyrArgGluAlaLysThr-ll 35-AspAlaSerGlyArgSerSerAlaValAlaGluGluArgThrAlaThrGluMetSerAla-54 73-CysSerGlyLysGlyValSer-79 89-ThrArgAlaSerSerGluThrSerSer-97 103-ArgAlaAlaGluMetArgSerPheArg-lll g505 AMPHI Regions - AMPHI 20-LeuThrAlaLeuLeuLysCysLeuSerLeuLeuSerLeuSerCysLeu-35 37-ThrLeuGlyAsnArg-41 89-ProAlaPhePheLysLysProGluAspIleGluThrMetPheLysAlaValHisGlyTrpGluHisValGlnG lnAlaLeuAsp-116 148-AlaMetTyrLysProProLysIleLysAlaIleAspLysIleMetGlnAlaGly-165 178-IleGlnGlyValLysGlnIleIleLysAlaLeuArg-189 209-GlyValTrpAlaAspPhePheGlyLysPro-218 Antigenic Index - Jameson-Wolf 39-GlyAsnArgLeuGly-43 50-LeuLysGluAspArgAlaArgIle-57 64-AlaGlyLeuAsnProAspThrGlnThrVal-73 79-GluThrAlaLysCysGlyLeu-85 92-PheLysLysProGluAspIleGluThr-100 114-AlaLeuAspLysGlyGluGlyLeu-121 131-TyrAspLeuGlyGlyArgTyrIleSer-139 151-LysProProLysIleLysAlaIleAspLysIleMetGln-163 165-GlyArgValArgGlyLysGlyLysThrAlaProThrGly-177 179-GlnGlyValLysGlnIleIleLys-186 188-LeuArgAlaGlyGlu-192 199-AspHisValProSerProGlnGluGlyGlyGlyVal-210 241-CysGluArgLeuProAspGlyGlnGly-249 257-ValGlnGlyGluLeuAsnGlyAsnLysAlaHisAsp-268 273-AsnArgAsnThrGluTyrTrp-279 292-AsnArgTyrLysThrPro-297 Hydrophilic Regions - Hopp-Woods 50-LeuLysGluAspArgAlaArgIle-57 65-GlyLeuAsnProAspThrGlnThr-72 79-GluThrAlaLysCysGlyLeu-85 92-PheLysLysProGluAspIleGluThr-100 114-AlaLeuAspLysGlyGlu-119 151-LysProProLysIleLysAlaIleAspLysIleMetGln-163 165-GlyArgValArgGlyLysGlyLysThrAla-174 188-LeuArgAlaGlyGlu-192 201-ValProSerProGlnGluGly-207 257-ValGlnGlyGluLeuAsnGlyAsnLysAlaHisAsp-268 g506 AMPHI Regions - AMPHI 6-GluValGlyArgIleAlaHisGlyCysGlyGlyValVal-18 25-ArgValValHisGlnValGluGlnGlyAlaArgLeuAla-37 56-PheGlnArgArgPhe-60 99-AlaThrArgThrIleAspGlyAsp-106 123 -GluGlnThrGlyLeuGln-128 138-GlyAsnGluValAlaArgCys-144 180-GlnValLysArgMetIleArgHisPhe-188 199-ValHisArgProPheArgGluLeuAlaAlaLeuAspGlyPheValGlnVal-215 224-GlyAspAspPheCysSerPhePheValGlyGlnValPheAsnProLeuLeu-240 249-LysThrPheAlaArgPheValPro-256 283-AsnLeuValGlnGlyPhe-288 313-PheValGlnValGlyGluPheAlaArgValAlaGlnGluGlu-326 372-GlyPhePheAlaAspPheAlaGluAsnPheGlyAlaGlyVal-385 408-PheGlyAspAspPheAlaHisGluValGlyGlu-418 465-CysSerPheSerGlnValGlyGlnMetGly-474 Antigenic Index - Jameson-Wolf 12-HisGlyCysGlyGly-16 31-GluGlnGlyAlaArgLeuAla-37 54-ValAspPheGlnArgArgPheGlyGluVal-63 98-ArgAlaThrArgThrIleAspGlyAspLeuAlaGlu-109 131-IleArgAlaArgAlaAspThrGlyAsnGluValAlaArgCysGluGly-146 176-ProAsnPheGlyGlnValLysArgMetIle-185 195-HisAspLeuAspValHisArgProPheArgGlu-205 224-GlyAspAspPheCysSer-229 244-MetGluPheHisProLysThrPhe-251 259-ValGlyMetArgThrGluAla-265 279-HisHisAspGlyAsnLeu-284 288-PheGlyGlnGlnArgProGluValProVal-297 320-AlaArgValAlaGlnGluGluHisGlyArgValValAla-332 344-PheGlnArgLysThrAlaAspVal-351 362-CysHisGlyGlyGluThrGlyGlu-369 391-CysTyrGlyLysArgThrGluArgAlaArgThr-401 408-PheGlyAspAspPheAlaHisGluVal-416 428-GlnGlnGlyAlaAlaArgAlaGlyGlyGln-437 459-GlyGlySerHisArgSerCysSer-466 471-GlyGlnMetGlyGlyLysArgLeuThrValArgPheGlyGlyLysArgIleArgAsnArgPheLeuAspCys AsnLysPheLeuGlu-499 508-LysThrMetAspAlaIleIle-514 516-GlnAspPheArgTyr-520 Hydrophilic Regions - Hopp-Woods 31-GluGlnGlyAlaArgLeuAla-37 54-ValAspPheGlnArgArgPheGlyGlu-62 98-ArgAlaThrArgThrIleAspGlyAspLeuAlaGlu-109 131-IleArgAlaArgAlaAspThrGlyAsnGluValAlaArgCysGluGly-146 180-GlnValLysArgMetIle-185 195-HisAspLeuAspVal-199 201-ArgProPheArgGlu-205 244-MetGluPheHisPro-248 259-ValGlyMetArgThrGluAla-265 289-GlyGlnGlnArgProGluVal-295 320-AlaArgValAlaGlnGluGluHisGlyArgValValAla-332 344-PheGlnArgLysThrAlaAspVal-351 364-GlyGlyGluThrGlyGlu-369 393-GlyLysArgThrGluArgAlaArgThr-401 412-PheAlaHisGluVal-416 429-GlnGlyAlaAlaArgAlaGlyGly-436 473-MetGlyGlyLysArgLeuThr-479 482-PheGlyGlyLysArgl1eArgAsnArgPheLeuAsp-493 508-LysThrMetAspAlaIleIle-514 516-GlnAspPheArgTyr-520 g513-2 AMPHI Regions - AMPHI 6-ThrGluTrpLeuHisGlyTrpValGlyAlaIleAsnAspProMetTrp-21 48-GlyArgSerIleLysGlu-53 66-GlyIleThrProPheGlnAlaPheValThrGlyLeuAla-78 119-SerSerLeuAlaGlnLeuPheLysValArgAsp-129 146-GlyLeuGlyGlnLysTrpLeuGlyVal-154 176-IleAlaAspThrVal-180 205-GlyGlyIleArgArgIleSerLysAlaAla-214 243-ValPheGlyGlnIlePheSer-249 259-GlyGlyLeuLeuGlyGlyLeuIle-266 288-AlaProAsnAlaAlaAlaAlaAla-295 303-GlnGlyMetIleGlnMetLeuGlyValPheValAsp-314 332-ProTyrGlyAspLeu-336 347-ValSerGlnValGlyGlnTrp-353 391-ThrAlaValPheArgMet-396 403-TyrPheGlyAlaValAla-408 423-IleMetAlaTrpIleAsnLeuValAlaIleLeuLeuLeuSer-436 Antigenic Index - Jameson-Wolf l-MetAsnGluAsnPhe-5 48-GlyArgSerIleLysGluMetLeuGlyGlyArgLysGlnGlyAspAspProHisGly-66 126-LysValArgAspCysAspAsnHisHisPheArgGlyGlyProAla-140 208-ArgArgIleSerLysAlaAlaGlu-215 273-GlyIleLysArgGlyLeuTyrSerAsnGluAlaGlyMetGlySerAlaProAsnAla-291 295-AlaGluValLysHisProValSer-302 331-GlnProTyrGlyAspLeuSerGly-338 375-AlaTyrAlaGluSerAsnVal-381 444-ArgAspTyrThrAlaLysLeuLysMetGlyLysAspProGluPheLysLeuSerGluHisProGlyLeuLys ArgArgIleLysSerAspValTrp-475 Hydrophilic Regions - Hopp-Woods 48-GlyArgSerIleLysGluMetLeuGlyGlyArgLysGlnGlyAspAspProHisGly-66 126-LysValArgAspCysAspAsnHisHis-134 208-ArgArgIleSerLysAlaAlaGlu-215 273-GlyIleLysArgGlyLeuTyr-279 295-AlaGluValLysHisProVal-301 450-LeuLysMetGlyLysAspProGluPheLysLeuSerGlu-462 464-ProGlyLeuLysArgArgIleLysSer-472 g515-l AMPHI Regions - AMPHI 8-ArgAlaAlaGlyValAlaArgGlyLeuHisSerGluPheAlaArg-22 59-AspValArgPhePheAlaGlnValGluGluIleGlyGlnAspPhePheAlaAspAla-77 90-AlaGlyGluCysAlaAspGluValSerAspGlnPro-101 122-GluSerAlaGlnSerAlaAlaGlyGlyGlyLeuThrAspGlyPheGly-137 176-CysGlyLysThrValGlyVal-182 192-LeuHisArgArgAla-196 233-ValAlaAspValLeuArg-238 251-PheGlyGlyValAlaGlyAspValGlyGlyGlyAlaAspGlyValAlaGlnGlyLeuPheGlyGluVal-27 3 306-HisAlaAspAlaLeuSerGluArgPheAla-315 334-AlaAlaGluValGluGluPheGlySerGlyValValGluGln-347 Antigenic Index - Jameson-Wolf 24-ValThrAlaGluGluIleAlaPhe-31 38-HisGluAlaArgArgGlyGlyAsnThrPhe-47 51-IleAlaAlaAlaGluArgAlaGlyAsp-59 67-GluGluIleGlyGln-71 77-AlaValAspGlnGluThr-82 84-LeuAlaValGluArgAlaAlaGlyGluCysAlaAspGluValSerAspGlnProAlaArgAsnGlyGlyIleG luGluAspGlyValAlaAlaCysArgAspAlaAlaAlaAlaGluSerAlaGln-125 128-AlaGlyGlyGlyLeuThrAspGly-135 160-GlyGlyAsnAspAlaAlaGlyAsn-167 192-LeuHisArgArgAla-196 217-AlaAspGlyGlyPheArg-222 242-GlyValGlyLysSerGlyAla-248 257-AspValGlyGlyGlyAlaAspGlyVal-265 284-AspValAsnGlyAsnValGln-290 309-AlaLeuSerGluArgPheAla-315 318-GlyPheGlyGlyGlyArgAlaArgCys-326 328-CysGlnValGluArgAlaAlaAlaGluValGluGluPheGlySerGlyVal-344 347-GlnHisAsnAsnLeu-351 Hydrophilic Regions - Hopp-Woods 24-ValThrAlaGluGluIleAlaPhe-31 38-HisGluAlaArgArgGlyGlyAsn-45 51-IleAlaAlaAlaGluArgAlaGlyAsp-59 77-AlaValAspGlnGluThr-82 84-LeuAlaValGluArgAlaAlaGlyGluCysAlaAspGluValSerAspGlnProAlaArgAsnGlyGlyIleG luGluAspGlyValAlaAlaCysArgAspAlaAlaAlaAlaGluSerAlaGln-125 162-AsnAspAlaAlaGly-166 192-LeuHisArgArgAla-196 258-ValGlyGlyGlyAlaAspGlyVal-265 309-AlaLeuSerGluArgPheAla-315 322-GlyArgAlaArgCys-326 328-CysGlnValGluArgAlaAlaAlaGluValGluGluPheGly-341 g519-l AMPHI Regions - AMPHI 13-ValPheGlyPheLysSerPhe-19 29-ValValGluArgLeuGlyArgPheHisArgAlaLeuThrAlaGly-43 105-MetAlaIleThrGlnLeuAlaGlnThrThrLeuArgSerVal-118 139-ValSerAlaLeuAspGluAlaAla-146 165-GlnGluIleLeuArgAlaMetGln-172 192-LysIleGluGlnIle-196 221-SerAsnAlaGluLysIleAlaArgIleAsn-230 249-AlaIleArgGlnIleAlaAlaAla-256 273-GlnTyrValAlaAlaPheAsnAsnLeuAlaLys-283 292-AlaAsnValAlaAspIleGlySerLeuIleSerAlaGlyMetLysIleIleAspSerSerLysThrAla-31 4 Antigenic Index - Jameson-Wolf 31-GluArgLeuGlyArgPheHisArg-38 58-HisSerLeuLysGluIleProLeuAspValProSerGln-70 72-CysIleThrArgAspAsnThrGlnLeuThrVal-82 91-ThrAspProLysLeuAlaSer-97 122-MetGluLeuAspLysThrPheGluGluArgAspGluIleAsn-135 141-AlaLeuAspGluAlaAlaGly-147 154-LeuArgTyrGluIleLysAspLeuValPro-163 175-IleThrAlaGluArgGluLysArgAlaArgIleAlaGluSerGluGlyArgLysIleGluGln-195 197-AsnLeuAlaSerGlyGlnArgGluAlaGluIleGlnGlnSerGluGlyGluAlaGlnAla-216 219-AsnAlaSerAsnAlaGluLysIleAlaArgIleAsnArgAlaLysGlyGluAlaGluSerLeuArgLeu-24 1 245-AlaAsnAlaGluAlaIleArg-251 258-GlnThrGlnGlyGlyAlaAspAlaValAsn-267 281-LeuAlaLysGluSerAsnThr-287 303-AlaGlyMetLysIleIleAspSerSerLysThrAlaLys-315 Hydrophilic Regions - Hopp-Woods 31-GluArgLeuGlyArgPheHisArg-38 58-HisSerLeuLysGluIleProLeu-65 73-IleThrArgAspAsnThr-78 91-ThrAspProLysLeu-95 122-MetGluLeuAspLysThrPheGluGluArgAspGluIleAsn-135 141-AlaLeuAspGluAlaAla-146 154-LeuArgTyrGluIleLysAspLeuValPro-163 175-IleThrAlaGluArgGluLysArgAlaArgIleAlaGluSerGluGlyArgLysIleGluGln-195 200-SerGlyGlnArgGluAlaGluIleGlnGlnSerGluGlyGluAlaGlnAla-216 221-SerAsnAlaGluLysIleAlaArgIleAsnArgAlaLysGlyGluAlaGluSerLeuArgLeu-241 245-AlaAsnAlaGluAlaIleArg-251 281-LeuAlaLysGluSerAsn-286 306-LysIleIleAspSerSerLysThrAlaLys-315 g520-l AMPHI Regions - AMPHI 109-AspGlyGlnIleTrpArgAlaPheSerSerLeuLys-120 Antigenic Index - Jameson-Wolf 20-LysProSerArgArgAlaLeu-26 47-AlaSerGlyLysIleSerLeuPro-54 84-ProProAsnAsnSerThrThrThrSerThrSerLeuArgAlaThrSerSerAsnGlySerLeuThrLysAlaA laAsp-109 122-HisMetAlaGluIleArgIleSerArgProLysArgArgGluIleSerSerAlaLeuSerArgAsnThrAla AlaAlaPro-148 150-ProThrValProLysProLysArgProMet-159 166-SerProCysLysProThrGluMet-173 Hydrophilic Regions - Hopp-Woods 20-LysProSerArgArgAlaLeu-26 93-ThrSerLeuArgAlaThrSerSer-100 103-SerLeuThrLysAlaAlaAsp-109 122-HisMetAlaGluIleArgIleSerArgProLysArgArgGluIleSer-137 140-LeuSerArgAsnThrAla-145 151-ThrValProLysProLysArgProMet-159 168-CysLysProThrGluMet-173 g521 AMPHI Regions - AMPHI 39-ThrLysProSerLysSerCys-45 50-LeuProProIleGly-54 86-ValLysThrValSerLysProAlaLysSer-95 126-AlaGlnLysMetLeu-130 132-GlnAlaArgLeuAlaLysGlyGlyAsn-140 146-11eAsnAlaLeuSer snValLeuAspArgGlnGlnAsnl1e-159 Antigenic Index - Jameson-Wolf 1-MetLysSerLysLeu-5 36-ValTyrThrThrLysProSerLysSerCysHisSerThrAspLeuProProIleGlyAsnTyrSerSerGluA rgTyrIle-62 65-GlnThrProGluProAlaProSerProSerAsnGlyGlyGln-78 80-ValLysTyrLysAlaProVal-86 88-ThrValSerLysProAlaLysSerAsnThrProProGlnGlnAlaProValAsnAsnSerArgArgSerIleL euGluAlaGluLeuSerAsnGluArgLysAlaLeuThrGluAlaGlnLysMetLeuSer-131 134-ArgLeuAlaLysGlyGlyAsnIleAsnHisGlnLys-145 152-ValLeuAspArgGlnGlnAsn-158 162-LeuGlnArgGluLeuGlyArg-168 Hydrophilic Regions - Hopp-Woods 1-MetLysSerLysLeu-5 40-LysProSerLysSerCysHis-46 57-SerSerGluArgTyrIle-62 66-ThrProGluProAlaProSerProSerAsnGly-76 80-ValLysTyrLysAlaProVal-86 88-ThrValSerLysProAlaLysSerAsnThrPro-98 105-AsnAsnSerArgArgSerIleLeuGluAlaGluLeuSerAsnGluArgLysAlaLeuThrGluAlaGlnLys MetLeuSer-131 152-ValLeuAspArgGlnGlnAsn-158 162-LeuGlnArgGluLeuGlyArg-168 g522 AMPHI Regions - AMPHI 57-LysIleValGluSerCysMetLys-64 96-MetTrpGluGlnProLeuAspGlyLeuSerGluLysGlnIleSerSerPheGlyLysLeuGlyAlaGlnGluG lnLeuAspLeuLeuGlyGlyAla-127 Antigenic Index - Jameson-Wolf 1-MetThrGluProLysHisGluThrProThrGluGluGlnValAlaAlaArgLysLysAlaLysAlaLysIleAr gThr-26 48-AlaMetSerLysProGlnAlaLysGlnLysIleValGluSerCysMetLys-64 71-LysTrpGlnAsnAspLeuLysAlaArgGlyLeuAspAlaAspAsnThrArgLeu-88 103-GlyLeuSerGluLysGlnIleSerSerPheGlyLysLeuGlyAla-117 128-AsnAlaPheGluThrArgAspLysGlnCysValAlaAspLeuLysAlaAsp-144 Hydrophilic Regions - Hopp-Woods 1-MetThrGluProLysHisGluThrProThrGluGluGlnValAlaAlaArgLysLysAlaLysAlaLysIleAr gThr-26 48-AlaMetSerLysProGlnAlaLysGlnLysIleValGluSerCysMet-63 72-TrpGlnAsnAspLeuLysAlaArgGlyLeuAspAlaAspAsnThrArgLeu-88 103-GlyLeuSerGluLysGlnIle-109 130-PheGluThrArgAspLysGlnCysValAlaAspLeuLysAlaAsp-144 g525-l AMPHI Regions - AMPHI 59-GluPheAlaGluPheValAsnSerHisProGln-69 86-LysHisTrpMetLysAsnGly-92 125-ArgLeuProThrIleAspGluTrpGluPhe-134 154-ThrIleLeuAspTrpTyr-159 164-ArgLysGlyLeuHisAspValGly-171 178-TrpGlyValTyrAsp-182 188-TrpGluTrpThrGlu-192 Antigenic Index - Jameson-Wolf 24-ValGlnIleGluGlyGlySerTyrArgProLeuTyrLeuLysLysAspThrGlyLeuIleLys-44 46-LysProPheLysLeuAspLysTyrProValThr-56 67-HisProGlnTrpGlnLysGlyArgIleGlySerLysGlnAlaGlu-81 88-TrpMetLysAsnGlySerArgSerTyrAlaProLysAlaGlyGluLeuLysGlnPro-106 122-GlnGlyLysArgLeuProThrIleAspGluTrpGlu-133 140-AlaThrGlnLysAsnGlySerAsnGluProGlyTyrAsnArgThr-154 159-TyrAlaAspGlyGlyArgLysGlyLeuHisAspValGlyLysAspArgProAsnTyr-177 190-TrpThrGluAspPheAsnSerSerLeuLeuSerSerGlyAsnAla-204 213-AlaSerValGlyAlaSerAspSerSerAsnTyr-223 234-SerLeuGlnSerLysTyr-239 245-GlyPheArgCysAlaSerArg-251 Hydrophilic Regions - Hopp-Woods 35-TyrLeuLysLysAspThrGlyLeuIleLys-44 46-LysProPheLysLeuAspLysTyrPro-54 71-GlnLysGlyArgIleGlySerLysGlnAlaGlu-81 91-AsnGlySerArgSerTyrAla-97 99-LysAlaGlyGluLeuLysGln-105 122-GlnGlyLysArgLeuProThr-128 140-AlaThrGlnLysAsnGlySerAsnGluProGlyTyr-151 162-GlyGlyArgLysGlyLeuHisAspValGlyLysAspArgProAsn-176 216-GlyAlaSerAspSerSerAsn-222 g527 AMPHI Regions - AMPHI 7-PhePheGlnProValGln-12 29-AspAlaAlaGluLeuValGluLeuPheAlaLeuPhePro-41 73-GlyLysGlyIleGluArgGlnValAspAsnIleAlaAspValTyrGlyPhe-89 Antigenic Index - Jameson-Wolf 19-GlyArgSerAlaValGlyMetGlyGlySerAspAlaAlaGlu-32 52-GlnLysProArgLeuGlyCysArg-59 71-PheMetGlyLysGlyIleGluArgGlnValAspAsnIleAla-84 107-LeuLeuArgLysGlyThrGlyLeuGluLysThrCysArgProLysProPheValGlnProHisGlyGlyArg -130 Hydrophilic Regions - Hopp-Woods 26-GlyGlySerAspAlaAlaGlu-32 53-LysProArgLeuGlyCys-58 71-PheMetGlyLysGlyIleGluArgGlnValAspAsnIleAla-84 107-LeuLeuArgLysGlyThrGlyLeuGluLysThrCysArgProLysPro-122 g528 AMPHI Regions - AMPHI 23-ArgLeuAlaGlyTrpTyrGluCysSerSerLeuSerGlyTrpCysLysProArgLysProAlaAlaIle-45 69-AsnArgSerValArg-73 87-ArgLysIleGlyLysPhe-92 106-ProLeuValGluArgPheLys-112 Antigenic Index - Jameson-Wolf 29-GluCysSerSerLeuSerGlyTrpCysLysProArgLysProAlaAla-44 49-AspIleGlyGlyGluSerProLeuSerLeuGluAspTyrGluIleProLeuSerAspGlyAsnArgSerValA rgAlaAsnGluTyrGluSerAlaGlnLysSerTyrPhe-85 88-LysIleGlyLysPheGluAlaCysGlyLeuAspTrpArgThrArgAspGlyLysProLeuValGluArgPheL ysGlnGluGlyPheAspCysLeuGluLysGlnGlyLeuArgArgAsnGlyLeuSerGluArgValArgTrp-135 Hydrophilic Regions - Hopp-Woods 37-CysLysProArgLysProAlaAla-44 54-SerProLeuSerLeuGluAspTyrGluIleProLeu-65 67-AspGlyAsnArgSerValArgAlaAsnGluTyrGluSerAlaGln-81 88-LysIleGlyLysPheGluAlaCys-95 99-TrpArgThrArgAspGlyLysProLeuValGluArgPheLysGlnGluGlyPheAspCysLeuGluLysGlnG lyLeuArgArgAsnGlyLeuSerGluArgValArgTrp-135 g531 AMPHI Regions - AMPHI 64-LeuAlaAspTyrMetAla-69 90-GlySerIleIleGlyIlePhePheSerLeuProGlyLeuIleLeuGly-105 108-IleGlyAlaAlaAlaGly-113 132-LeuLeuGlyLeuValVal-137 Antigenic Index - Jameson-Wolf 77-ThrGlyAlaGlyLysLeuAlaVal-84 114-GluLeuIleAspArgArgAsnMet-121 Hydrophilic Regions - Hopp-Woods 114-GluLeuIleAspArgArgAsnMet-121 g532-2 AMPHI Regions - AMPHI 6-LysLysGlnAlaAsp-10 27-AlaLeuLeuSerAlaValThrHisLeuLeuAlaIlePheValProMetIleThr-44 76-TyrLeuGlnValAsnArgPheGlySerVal-85 122-SerThrLeuLeuGlyValSerPhe-129 147-LysValIleThrProThrVal-153 184-ThrPheGlySerMetGluAsnLeuGly-192 206-CysMetLysAsnPro-210 224-GlyTyrIleValAlaLeu-229 236-PheSerAlaLeuGlnAsnLeuPro-243 271-LeuGlyValPheGluAlaValGlyAspLeuThrAla-282 297-ThrLysArgLeuArgGlyGlyVal-304 307-AspGlyLeuValSerValIleAlaThrAlaLeuGly-318 338-AlaSerArgHisValGlyLysTyr-345 361-ArgAlaPheThrThrIleProSerProVal-370 Antigenic Index - Jameson-Wolf 3-GluThrMetLysLysGlnAlaAspSerProAspLeu-14 16-TyrGlyLeuGluAspArgProProPhe-24 80-AsnArgPheGlySer-84 94-XxxXxxXxxXxxSerSer-99 108-AlaGlyMetLysGluGlyGlyLeuSerGluGlyAla-119 177-PheGlyAlaLysAlaAspGlyThrPheGlySer-187 207-MetLysAsnProLeuLeuArg-213 286-ValSerAspGlnProIleGluGlyGluGluTyrThrLysArgLeuArgGlyGlyValLeu-305 394-GlyIleArgArgArgGluAlaVal-401 431-IleSerGlyGlyGly-435 445-LeuProGluAspLysThrGluAlaAlaValLysPheAspThrAspHisLeuGluHis-463 Hydrophilic Regions - Hopp-Woods 3-GluThrMetLysLysGlnAlaAspSerProAsp-13 18-LeuGluAspArgProProPhe-24 109-GlyMetLysGluGlyGlyLeuSer-116 179-AlaLysAlaAspGly-183 289-GlnProIleGluGlyGluGluTyrThrLysArgLeuArgGly-302 394-GlyIleArgArgArgGluAlaVal-401 445-LeuProGluAspLysThrGluAlaAlaValLysPheAspThrAspHisLeuGluHis-463 g537 AMPHI Regions - AMPHI 38-GlnIleArgAspGlyGlyAspAlaLeuHisTyrLeuAsnArgIle-52 86-HisGlyGluHisHis-90 109-GlyTyrLeuTyrAsnGlyValHisGlu-117 138-ArgGlnValAspAlaLeuMetSerAlaIleTyr-148 180-AsnGlySerPheGluArg-185 190-GlyArgArgGlnProGluAlaGlyArgLysTyrTyrArgAsnAlaCys-205 281-ArgProValArgValLeuThrAlaGly-289 315-TyrThrAlaVa1PheAspTyrVa1ArgAsnGly-325 374-ThrArgTyrThrTyr-378 Antigenic Index - Jameson-Wolf 21-ThrGlnAsnGlnSerLeuProAlaGly-29 32-ValTyrProSerAlaProGlnIleArgAspGlyGlyAspAla-45 6 -AsnSerAlaArgArgHisAlaArg-76 80-LeuAsnProGluAspGlyHisGlyGluHisHisProAspAsnProHis-95 99-GlnLysLeuThrGluArgThrArgLeu-107 115-ValHisGluAsnIleSerThrGluGluGluAlaAlaGluSerSerAspSerAspIleArgThrGlnGlnArg GlnValAsp-141 152-SerLeuLeuAspArgHisThrAspGluAlaGly-162 165-PheValArgGluAsnGlyLysThr-172 178-GlnGlyAsnGlySerPheGluArgAlaCysAlaLysGlyArgArgGlnProGluAlaGlyArgLysTyrTyr ArgAsnAlaCysHisAsnGly-208 238-TyrGlyGluArgProAspProValProGluTyrGluIleThrGlyAsnProAlaSer-256 258-AspPheSerGluAlaAlaGly-264 266-IleAlaMetLysSer-270 274-TyrGlnGlyLysAsnGluIleArgPro-282 287-ThrAlaGlyAsnAspProAsnGlyArgLeuThr-297 321-TyrValArgAsnGlyArgHisAlaGln-329 334-PheArgThrArgLysProAspTyrProTyr-343 345-GluValAsnGlyGlyGluThrLeuAlaValArgLysGlyGluLys-359 364-TrpArgGlyArgTrpCysLeu-370 380-ArgGlnPheGlyAsnSer-385 389-LeuArgHisGluAlaGlyGly-395 402-GlyMetAlaGlySerArgIleArgLeuThrProGluAspSerProGluArgGly-419 Hydrophilic Regions - Hopp-Woods 37-ProGlnIleArgAspGlyGlyAsp-44 69-AsnSerAlaArgArgHisAlaArg-76 81-AsnProGluAspGlyHisGlyGluHisHisProAsp-92 100-LysLeuThrGluArgThrArgLeu-107 119-IleSerThrGluGluGluAlaAlaGluSerSerAspSerAspIleArgThrGlnGlnArgGlnValAsp-14 1 152-SerLeuLeuAspArgHisThrAspGluAlaGly-162 165-PheValArgGluAsnGlyLys-171 181-GlyΞerPheGluArgAlaCysAlaLysGlyArgArgGlnProGluAlaGlyArgLysTyrTyrArg-202 240-GluArgProAspProValProGluTyrGluIle-250 258-AspPheSerGluAlaAlaGly-264 266-IleAlaMetLysSer-270 275-GlnGlyLysAsnGluIleArgPro-282 289-GlyAsnAspProAsnGlyArgLeuThr-297 323-ArgAsnGlyArgHisAlaGln-329 334-PheArgThrArgLysProAsp-340 352-LeuAlaValArgLysGlyGluLys-359 389-LeuArgHisGluAla-393 406-SerArgl1eArgLeuThrProGluAspSerProGluArgGly-419 g538 AMPHI Regions - AMPHI 41-ThrAlaLeuAlaGluAlaValGluLeuValLysAlaAlaGly-54 78-LysAlaAlaGluLeuSerGluAlaValAla-87 104-GlnGluArgAsnLeuGluLysIleLeuGlnCysArgValLeuAspArgVal-120 144-GlnLeuSerHisLeuAlaGlyArgLeuIleArgGlyTyrGlyHisLeuGln-160 187-IleAsnAlaLeuLysLysGlnLeuAla-195 211-GlyArgIleLysThrPheAlaLeuValGlyTyrThrAsn-223 230-PheAsnArgLeuThrLys-235 270-GlyPheValSerAspLeuProHisLysLeuIleSerAlaPheSerAlaThrLeuGlu-288 306-AsnSerGlyGlnGlnIleGluAspValGluAsnValLeuGlnGluIleHis-322 364-GluAsnThrGlyIleAspAlaLeuArgGluAlaIleAlaGluTyrCysAla-380 Antigenic Index - Jameson-Wolf l-SerGlyArgThrGlyArgAsnSerAlaThrGlnAlaGlnProGluArgVal-17 24-LeuAspLysAspAspThrGlySerAsnAlaAlaArg-35 47-ValGluLeuValLys-51 53-AlaGlyGlyAspSerValArgValGluThrAlaLysArgAspArgProHisThr-70 76-ThrGlyLysAlaAlaGluLeuSerGlu-84 99-GluLeuThrProThrGlnGluArgAsnLeuGluLys-110 128-AlaArgArgAlaArgThrGlnGluGlyArgLeuGlnVal-140 160-GlnSerGlnArgGlyGlyIleGlyMetLysGlyProGlyGluThrLysLeuGluThrAspArgArgLeuThr Ala-184 188-AsnAlaLeuLysLysGlnLeuAlaAsnLeuLysLysGlnArgAlaLeuArgArgLysSerArgGluSerGly ArgIleLysThr-215 223-AsnValGlyLysSerSerLeu-229 232-ArgLeuThrLysSerGlyIleTyrAla-240 286-ThrLeuGluGluThrValGln-292 302-AlaAlaAlaArgAsnSerGlyGlnGlnIleGluAspValGluAsnValLeu-318 332-TyrAsnLysThrAspLeuLeuProSerGluGluGlnAsnThrGlyIle-347 364-GluAsnThrGlyIleAspAlaLeuArgGluAlaIle-375 380-AlaAlaAlaProAsnThrAspGluThrGluMetPro-391 Hydrophilic Regions - Hopp-Woods 1-SerGlyArgThrGlyArgAsnSerAla-9 12-AlaGlnProGluArg-16 24-LeuAspLysAspAspThrGlySerAsnAlaAlaArg-35 47-ValGluLeuValLys-51 53-AlaGlyGlyAspSerValArgValGluThrAlaLysArgAspArgProHis-69 77-GlyLysAlaAlaGluLeuSerGlu-84 100-LeuThrProThrGlnGluArgAsnLeuGluLys-110 128-AlaArgArgAlaArgThrGlnGluGlyArgLeuGlnVal-140 160-GlnSerGlnArgGlyGlyIle-166 170-GlyProGlyGluThrLysLeuGluThrAspArgArgLeuThrAla-184 188-AsnAlaLeuLysLysGlnLeuAlaAsnLeuLysLysGlnArgAlaLeuArgArgLysSerArgGluSerGly ArgIleLys-214 286-ThrLeuGluGluThrValGln-292 302-AlaAlaAlaArgAsnSerGlyGlnGlnIleGluAspValGluAsnValLeu-318 336-AspLeuLeuProSerGluGluGlnAsn-344 369-AspAlaLeuArgGluAlaIle-375 383 -ProAsnThrAspGluThrGluMetPro-391 g538 AMPHI Regions - AMPHI 41-ThrAlaLeuAlaGluAlaValGluLeuValLysAlaAlaGly-54 78-LysAlaAlaGluLeuSerGluAlaValAla-87 104-GlnGluArgAsnLeuGluLysIleLeuGlnCysArgValLeuAspArgVal-120 144-GlnLeuSerHisLeuAlaGlyArgLeuIleArgGlyTyrGlyHisLeuGln-160 187-IleAsnAlaLeuLysLysGlnLeuAla-195 211-GlyArgIleLysThrPheAlaLeuValGlyTyrThrAsn-223 230-PheAsnArgLeuThrLys-235 270-GlyPheValSerAspLeuProHisLysLeuIleSerAlaPheSerAlaThrLeuGlu-288 306-AsnSerGlyGlnGlnIleGluAspValGluAsnValLeuGlnGluIleHis-322 364-GluAsnThrGlyIleAspAlaLeuArgGluAlaIleAlaGluTyrCysAla-380 Antigenic Index - Jameson-Wolf l-SerGlyArgThrGlyArgAsnSerAlaThrGlnAlaGlnProGluArgVal-17 24-LeuAspLysAspAspThrGlySerAsnAlaAlaArg-35 47-ValGluLeuValLys-51 53-AlaGlyGlyAspSerValArgValGluThrAlaLysArgAspArgProHisThr-70 76-ThrGlyLysAlaAlaGluLeuSerGlu-84 99-GluLeuThrProThrGlnGluArgAsnLeuGluLys-110 128-AlaArgArgAlaArgThrGlnGluGlyArgLeuGlnVal-140 160-GlnSerGlnArgGlyGlyIleGlyMetLysGlyProGlyGluThrLysLeuGluThrAspArgArgLeuThr Ala-184 188-AsnAlaLeuLysLysGlnLeuAlaAsnLeuLysLysGlnArgAlaLeuArgArgLysSerArgGluSerGly ArgIleLysThr-215 223-AsnValGlyLysSerSerLeu-229 232-ArgLeuThrLysSerGlyIleTyrAla-240 286-ThrLeuGluGluThrValGln-292 302-AlaAlaAlaArgAsnSerGlyGlnGlnIleGluAspValGluAsnValLeu-318 332-TyrAsnLysThrAspLeuLeuProSerGluGluGlnAsnThrGlyIle-347 364-GluAsnThrGlyIleAspAlaLeuArgGluAlaIle-375 380-AlaAlaAlaProAsnThrAspGluThrGluMetPro-391 Hydrophilic Regions - Hopp-Woods l-SerGlyArgThrGlyArgAsnSerAla-9 12-AlaGlnProGluArg-16 24-LeuAspLysAspAspThrGlySerAsnAlaAlaArg-35 47-ValGluLeuValLys-51 53-AlaGlyGlyAspSerValArgValGluThrAlaLysArgAspArgProHis-69 77-GlyLysAlaAlaGluLeuΞerGlu-84 100-LeuThrProThrGlnGluArgAsnLeuGluLys-110 128-AlaArgArgAlaArgThrGlnGluGlyArgLeuGlnVal-140 160-GlnSerGlnArgGlyGlyIle-166 170-GlyProGlyGluThrLysLeuGluThrAspArgArgLeuThrAla-184 188-AsnAlaLeuLysLysGlnLeuAlaAsnLeuLysLysGlnArgAlaLeuArgArgLysSerArgGluSerGly ArgIleLys-214 286-ThrLeuGluGluThrValGln-292 302-AlaAlaAlaArgAsnSerGlyGlnGlnIleGluAspValGluAsnValLeu-318 336-AspLeuLeuProSerGluGluGlnAsn-344 369-AspAlaLeuArgGluAlalle-375 383 -ProAsnThrAspGluThrGluMetPro-391 g539 AMPHI Regions - AMPHI 18-ArgGlnArgGluHisHisArgLeuHisHisThr-28 44-LeuValGlyGlyPheAspPheLeuArgValIleGlyCysGlyGly-58 108-AlaGlyGlyAlaGlyAsnAlaAla-115 123-ArgAlaIleMetGlyPhe-128 142-AspLeuValGluAspPheLeu-148 172-AspAlaLeuCysAspCysLeuThr-179 197-GlnValPheGlyAsnValGln-203 220-PheGlyAlaAlaAlaGlnTyr-226 328-GlyArgSerLeuThrAsnPro-334 354-ValSerArgValAlaLysSerTrpSerPheAla-364 366-MetProAspLeuValSerArgLeu-373 Antigenic Index - Jameson-Wolf l-MetGluAspLeuGlnGluIleGly-8 15-LysValGlyArgGlnArgGluHisHisArg-24 26-HisHisThrGlnSerGlyAsnGlyLysAlaAspAsp-37 63-ProAspPheGlnGlnAsnValGlyGluAlaAsp-73 77-ValProAspAspAlaAlaAla-83 88-IleGluValAspAlaAspAspAlaValCys-97 102-LeuPheAspGlnProAspAlaGlyGlyAlaGlyAsnAlaAlaGluHis-117 169-GlyIleAspAspAlaLeuCys-175 229-MetAlaSerArgSerAlaSer-235 242-ThrGluMetArgThr-246 261-CysSerSerAspGlySerArgSer-268 304-ThrThrCysSerSerThrSer-310 313-ThrValSerSerLysValAlaGluLysAlaGluIle-324 326-LeuCysGlyArgSerLeuThrAsnProThrVal-336 348-TyrSerArgArgAlaValVal-354 356-ArgValAlaLysSer-360 369-LeuValSerArgLeuAsnArgLeuAspLeu-378 Hydrophilic Regions - Hopp-Woods l-MetGluAspLeuGlnGluIleGly-8 15-LysValGlyArgGlnArgGluHisHisArg-24 31-GlyAsnGlyLysAlaAspAsp-37 69-ValGlyGluAlaAsp-73 78-ProAspAspAlaAlaAla-83 88-IleGluValAspAlaAspAspAlaValCys-97 102-LeuPheAspGlnProAspAlaGlyGly-llO 113-AsnAlaAlaGluHis-117 169-GlyIleAspAspAlaLeu-174 230-AlaSerArgSerAla-234 242-ThrGluMetArgThr-246 263-SerAspGlySerArg-267 317-LysValAlaGluLysAlaGluIle-324 348-TyrSerArgArgAlaValVal-354 369-LeuValSerArgLeuAsnArgLeuAspLeu-378 g542 AMPHI Regions - AMPHI 6-ArgIleArgArgCysSerVal-12 Antigenic Index - Jameson-Wolf l-MetProLysTrpSerArgIleArgArgCysSerVal-12 29-ProProSerAsnAla-33 37-ValArgLeuLysSerΞerAspGlyIleAlaSer-47 56-GlySerMetProSerGluThrValSerHisLysSerAspSerSerArgAsnThrSerAlaSerArgArgAsnV alSerProLysCysProPheGly-87 90-CysArgGlnAspAlaAlaLysProArgArgPheGlyGlyLys-103 107-LeuThrGlySerArg-lll Hydrophilic Regions - Hopp-Woods 5-SerArgIleArgArgCysSer-ll 37-ValArgLeuLysSerΞerAspGlyIleAla-46 58-MetProSerGluThrValSerHisLysSerAspSerSerArgAsnThrSerAlaSerArgArgAsnValSerP ro-82 90-CysArgGlnAspAlaAlaLysProArgArgPheGlyGly-102 g544-2 AMPHI Regions - AMPHI 55-PheTrpPheProSerCysProGlyCysValSerGluMetProLysValThrLysThrAlaAsnAspTyrLys- 78 85-LeuAlaValAlaGlnProIleAspProIleGluSerValArgGlnTyrVal-101 116-LysAlaValGlyGlnAlaPhe-122 Antigenic Index - Jameson-Wolf 1-MetLysLysIleLeu-5 22-IleProAspSerLysThrAlaPro-29 35-AspLeuHisGlyLysThrValSerAsnAlaAspLeuGlnGly-48 59-SerCysProGlyCys-63 66-GluMetProLysValThrLysThrAlaAsnAspTyrLysAsnLysAspPhe-82 90-ProIleAspProIleGluSerValArgGlnTyrValLysAspTyrGly-105 113-AspAlaAspLysAlaVal-118 133-IleGlyLysLysGlyGluIleLeu-140 144-ValGlyGluProAspPheGlyLysLeuTyrGlnGluIleAspThr-158 Hydrophilic Regions - Hopp-Woods 1-MetLysLys11eLeu-5 23-ProAspSerLysThr-27 66-GluMetProLysValThrLysThrAlaAsnAspTyrLysAsnLysAspPhe-82 92-AspProIleGluSerValArgGlnTyrValLys-102 113-AspAlaAspLysAlaVal-118 133-IleGlyLysLysGlyGluIle-139 g547 AMPHI Regions - AMPHI 7-PheAsnLysThrValAlaSerPheAlaGlnIleValGluThrPheAspVal-23 62-AsnArgSerPheLys-66 120-GluLeuLeuThrIleLeuValLys-127 Antigenic Index - Jameson-Wolf 3 -ValAspAsnGlyPheAsnLysThrVal-11 35-GlnMetLysGlnArgCysGly-41 56-CysGlyPheGluIleProAsnArgSerPheLysGlu-67 76-LeuSerGluArgPheArgThrAsnAlaGluValGluMet-88 128-AsnLeuSerProAsnGlyLysLysArgPhe-137 Hydrophilic Regions - Hopp-Woods 36-MetLysGlnArgCys-40 60-IleProAsnArgSerPheLysGlu-67 76-LeuSerGluArgPheArgThrAsnAlaGluValGluMet-88 129-LeuSerProAsnGlyLysLysArgPhe-137 g548 AMPHI Regions - AMPHI 7-SerPheLeuValLeuAlaAlaLeuAlaAlaCysLys-22 31-AlaAlaSerSerSer-35 41-AlaGluAsnAlaAlaLysPro-47 89-PheThrHisCysProAspValCysProThr-98 103-TyrSerAspThrLeuLysGlnLeuGlyGlyGln-113 132-GluIleIleGlyLysTyrAlaLys-139 Antigenic Index - Jameson-Wolf 22-LysProGlnAspAsnSerAla-28 33-SerSerSerAlaSer-37 39-ProAlaAlaGluAsnAlaAlaLysProGlnThrArgGlyThrAspMetArgLysGluAspIleGlyGlyAspP heThrLeuThrAspGlyGluGlyLysProPheSer-74 76-SerAspLeuLysGly-80 93-ProAspValCysPro-97 104-SerAspThrLeuLysGlnLeuGlyGlyGlnAlaLysAspValLys-118 124-IleAspProGluArgAspThrProGluIleIleGlyLysTyrAlaLysGlnPheAsnProAspPhe-145 150-AlaThrGlyGlyGln-154 169-Lys11eAsnGlnLysAspAspSerGluAsnTyrLeu-180 189-LeuIleAspLysAsnGlyGlu-195 200-SerProTyrGlySerGluProGluThrIleAlaAlaAspVal-213 Hydrophilic Regions - Hopp-Woods 22-LysProGlnAspAsnSerAla-28 39-ProAlaAlaGluAsnAlaAlaLysProGlnThrArgGlyThrAspMetArgLysGluAspIleGlyGly-61 64-ThrLeuThrAspGlyGluGlyLysPro-72 76-SerAspLeuLysGly-80 lll-GlyGlyGlnAlaLysAspValLys-118 124-IleAspProGluArgAspThrProGluIleIle-134 170-IleAsnGlnLysAspAspSerGluAsnTyrLeu-180 191-AspLysAsnGlyGlu-195 203-GlySerGluProGluThrIleAlaAlaAspVal-213 g553 AMPHI Regions - AMPHI 31-LeuAlaAlaValAlaGlyPheTyrGlyPheTyrThrAspLeu-44 59-AsnLeuAlaAspIleValArgPheAlaAspAsp-69 83-GluLeuGlySerLeu-87 99-HisPheValValLeu-103 162-GlyIleSerGlyLeuGlyArgThrLeuPhe-171 173-LeuLeuAlaLeuAlaAlaAlaMetGluValPheAlaPheLeu-186 232-HisAspIleTyrSerLeuProProPro-240 Antigenic Index - Jameson-Wolf H-LeuThrLysLysLeu-15 45-ArgAlaLeuArgSerLysTyr-51 55-LeuLysGlyGluAsnLeuAlaAsp-62 75-ArgAlaLeuArgLeuAspLeuAspGluLeuGlySer-86 106-ValSerSerAspGly-llO 115-AspProAlaSerGlyArgArgLysValLysThrGluGluIleSerArgLysPheThr-133 140-TrpProAsnThrArgPheGluAlaGlyGluGluLysGlnGluIleArg-155 163-IleSerGlyLeuGly-167 192-LysIleGlyArgGlyGluSer-198 202-IleGlyArgSerGlyCysGlyLysSerThrLeu-212 216-LeuSerGlyAsnLeuProProGluSerGlyLysVal-227 245-PheGluCysAspGlyGlnGlyArgThr-253 258-GlyLeuAsnLeuAsnArg-263 Hydrophilic Regions - Hopp-Woods H-LeuThrLysLysLeu-15 45-ArgAlaLeuArgSer-49 55-LeuLysGlyGluAsnLeuAlaAsp-62 75-ArgAlaLeuArgLeuAspLeuAspGluLeuGlySer-86 106-ValSerSerAspGly-llO 116-ProAlaSerGlyArgArgLysValLysThrGluGluIleSerArgLysPheThr-133 144-ArgPheGluAlaGlyGluGluLysGlnGluIleArg-155 192-LysIleGlyArgGlyGluSer-198 205-SerGlyCysGlyLys-209 220-LeuProProGluSerGlyLys-226 245-PheGluCysAspGlyGlnGly-251 g554 AMPHI Regions - AMPHI 35-AlaProThrLeuGlnThrProGluThrLeu-44 71-AlaAlaLeuThrGlnLeuMet-77 110-ArgMetPheValArgProGlyAspThrVal-119 124-LeuLeuLysGlyMetIleAla-130 141-AlaAspArgLeuGlyAsnGlySerIleGluAsnPheValGlnGlnMetAsnLysGlu-159 193-GluAlaLeuMetArgAspPheProGluTyrTyrProLeuPheSer-207 280-ArgAlaLeuGlnAlaPheAspThrPro-288 296-ThrValAlaGlnIle-300 331-GluGlnIleLeuGluThrIleGlnProIleProAla-342 Antigenic Index - Jameson-Wolf 24-SerProAlaProAsnArgProThr-31 37-ThrLeuGlnThrProGluThr-43 53-LeuGlnSerArgGlnThrLeuSerAlaLysAsnThrAsnThrProValGlu-69 84-LysAsnMetLysSerGlyAsnIleGlnSerGluGluAsnLeuLysIleProGlu-101 104-TrpAlaSerGluGlySerArgMetPheValArgProGlyAspThrValSerThrAspLysLeuLeu-125 142-AspArgLeuGlyAsnGlySerIleGluAsnPhe-152 156-MetAsnLysGluAlaArgArgLeuGlyMetLysAsnThrValPheLysAsnProThrGlyLeuGlyArgGlu GlyGlnValSerThrAlaLysAspLeuSerLeu-190 194-AlaLeuMetArgAspPheProGluTyrTyr-203 214-GluAsnIleGluGlnAsnAsnArgAsnIleLeu-224 226-TyrArgAspAsnAsnValAsnGlyLeuLysAlaGlyHisThrGluSerGlyGlyTyr-244 250-TyrSerGlyAsnGlyArgHis-256 262-LeuGlySerGluSerAlaGluThrArgAlaSerAspAsnSerLysLeuLeuAsn-279 286-AspThrProLysIleTyrProLysGlyLysThr-296 302-IleSerGlyGlySerLysLysThrValArg-311 323-ProHisLysGluAlaLysMetAlaGluGlnIleLeu-334 342-AlaProValLysLysGlyGlnIleLeuGlyLysIleLysIleArgGlnAsnGlyHisThrIleAlaGluLys GluIleValAla-369 371-GluAsnValGluLysArgSerArgTrpGlnArgLeu-382 Hydrophilic Regions - Hopp-Woods 26-AlaProAsnArgProThr-31 57-GlnThrLeuSerAlaLysAsnThrAsnThrProValGlu-69 85-AsnMetLysSerGlyAsnIleGlnSerGluGluAsnLeuLysIleProGlu-101 107-GluGlySerArgMetPheValArgProGlyAspThrValSerThrAspLysLeuLeu-125 156-MetAsnLysGluAlaArgArgLeuGlyMet-165 174-ThrGlyLeuGlyArgGluGlyGlnValSerThrAlaLysAspLeuSerLeu-190 214-GluAsnIleGluGlnAsnAsnArg-221 227-ArgAspAsnAsnValAsn-232 237-GlyHisThrGluSerGly-242 264-SerGluSerAlaGluThrArgAlaSerAspAsnSerLysLeuLeuAsn-279 289-LysIleTyrProLysGlyLysThr-296 304-GlyGlySerLysLysThrValArg-311 323-ProHisLysGluAlaLysMetAlaGluGlnIleLeu-334 343-ProValLysLysGlyGlnIle-349 353-IleLysIleArgGlnAsnGly-359 362-IleAlaGluLysGluIleValAla-369 371-GluAsnValGluLysArgSerArgTrp-379 g556 AMPHI Regions - AMPHI 61-1leGluArgLeuLys-65 Antigenic Index - Jameson-Wolf l-MetAspAsnLysThrLysLeuArgLeu-9 52-ThrSerArgArgGlnGlnArgGlnPheIleGluArgLeuLysLysPheAspIleAspProGluLysGlyArgI leAsnGluAlaAsnLeuArgArgMetTyrHisSerGlyGlyGlnHisGlnLysAspAla-95 102-SerGlnLysCysSerValAspGluAlaHisAlaMetPheLysLysArgProThrArgGlnGluIleAsn-12 4 127-AlaAlaLysGlnSerArgGlyGlnLysArgProHisArg-139 Hydrophilic Regions - Hopp-Woods l-MetAspAsnLysThrLysLeuArgLeu-9 53-SerArgArgGlnGlnArgGlnPheIleGluArgLeuLysLysPheAspIleAspProGluLysGlyArgIleA snGluAlaAsnLeuArgArgMetTyr-85 90-GlnHisGlnLysAspAla-95 105-CysSerValAspGluAlaHisAlaMetPheLysLysArgProThrArgGlnGluIleAsn-124 127-AlaAlaLysGlnSerArgGlyGlnLysArgProHisArg-139 g557 AMPHI Regions - AMPHI 22-GlyAlaAspGlyIle-26 55-SerGlyArgValAspAspAlaAla-62 113-ThrValSerValArgArgIleLeuAspTyrAlaAsp-124 142-ArgGlnAspValAlaGluGlnIle-149 Antigenic Index - Jameson-Wolf 20-LeuLysGlyAlaAspGlyIleSerProProLeuThrTyrArgSerTrpHisIleGluGlyGlyGlnAlaLeu- 43 54-AlaSerGlyArgValAspAspAlaAlaGly-63 68-LeuArgIleAspSerValSerGlnAsnLysGluThrTyrThr-81 100-GlnValLeuLysArgGlyGluProValGlyLysProMet-112 118-ArgIleLeuAspTyrAlaAspAsnGluIleLeuGlyLysGlnGluGluGluGluThrLeu-137 141-MetArgGlnAspValAlaGluGlnIleValArg-151 Hydrophilic Regions - Hopp-Woods 21-LysGlyAlaAspGlyIle-26 56-GlyArgValAspAspAlaAlaGly-63 68-LeuArgIleAspSerValSerGlnAsnLysGluThrTyrThr-81 100-GlnValLeuLysArgGlyGluProValGly-109 126-GluIleLeuGlyLysGlnGluGluGluGluThrLeu-137 141-MetArgGlnAspValAlaGluGlnIleValArg-151 g560 AMPHI Regions - AMPHI 30-PheArgAspGlyAlaHisLysMetAlaArgValTrpValGly-43 167-ArgMetAlaLysMetPhe-172 192-PheLeuLysTyrProGlyGlu-198 216-GluLeuMetGluLysCysGluHisLeuIleGlu-226 Antigenic Index - Jameson-Wolf 29-ProPheArgAspGlyAlaHisLysMet-37 63-GluHisIleProAspArgProSer-70 75-LysHisGlnSerGlyTrpGlu-81 95-ValAlaLysArgGluLeuPhe-101 116-IleGlyIleAspArgAsnAsnArgArgGluAlaAsnGluGlnLeuIle-131 134-GlyLeuAlaArgLysAsnGluGlyTyr-142 148-ProGluGlyThrArgLeuAlaProGlyLysArgGlyLysTyrLysLeuGlyGly-165 182-AsnSerGlyGluPheTrpProLysAsnSerPheLeuLysTyrProGlyGluIle-199 209-HisAlaSerGlySerGluAlaGluLeuMetGluLysCysGluHisLeuIle-225 242-MetProSerGluThr-246 Hydrophilic Regions - Hopp-Woods 29-ProPheArgAspGlyAlaHisLysMet-37 64-HisIleProAspArgProSer-70 95-ValAlaLysArgGluLeuPhe-101 116-IleGlyIleAspArgAsnAsnArgArgGluAlaAsnGluGlnLeuIle-131 134-GlyLeuAlaArgLysAsnGlu-140 149-GluGlyThrArgLeuAlaProGlyLysArgGlyLysTyrLysLeuGlyGly-165 211-SerGlySerGluAlaGluLeuMetGluLysCysGluHisLeuIle-225 242-MetProSerGluThr-246 g561-2 AMPHI Regions - AMPHI 6-ArgPheSerAspGly-10 22-GlyLeuTrpValGlyLeuAlaAla-29 46-AlaSerValIleGluGluAlaGlyAsn-54 74-GlnIleAspAsnGlnIleAlaGluPheGluLysSerLeuLysArgIleSerGlnSerAsp-93 128-AlaTyrArgArgProThrGlnIle-135 188-ValIleArgProLeuGlnAlaLeuArgGluGlyAlaGluArgIleGly-203 219-PheLysGlnValGlyArgCysPheAsnGln-228 237-TyrAspAspLeuGluGlyGln-243 247-GlnThrHisAsnLeuGluLysGln-254 263-ArgThrThrArgAspLeuHisGlnSerTyr-272 276-GlnAlaAlaGluGluPheLeuAsnHisIleLeuPro-287 358-GlnThrLeuIleArgGlnLeuGly-365 391-GlnGlyLeuHisAspSerIleAlaGlnAlaLeuThr-402 433-GlyValGlnGluCysTyrGluAspValArgGluLeu-444 455-LysGluPheProGluAlaValAlaAspLeuPheAlaArgPhe-468 503-LeuSerAsnIleArgLysHisAlaArg-511 539-ThrGluLysIleGlyGluProThr-546 Antigenic Index - Jameson-Wolf 4-ProThrArgPheSerAspGlyIlePro-12 48-ValIleGluGluAlaGlyAsn-54 66-AlaGlyGluGlySerProArgAlaGlnIleAspAsnGlnIleAlaGluPheGluLysSerLeuLysArgIleS erGlnSerAspAlaIleHis-96 99-IleProSerAspAsnProLeuAla-106 124-ProProLeuGlnAlaTyrArgArgProThrGlnIleGluLeu-137 152-GluAsnAlaGlyGluLysAsnThrTrpTrp-161 193-GlnAlaLeuArgGluGlyAlaGluArgIleGlyGlnArgHisPheAspIleProValProGluAspGlyThr ProGluPheLysGlnValGlyArgCysPheAsn-227 235-ThrLeuTyrAspAspLeuGluGlyGlnValAlaGluGlnThrHisAsnLeuGluLysGlnAsnArgAsnLeu -258 263-ArgThrThrArgAspLeuHisGlnSerTyrThrProArgGlnAlaAlaGluGluPhe-281 291-AlaGlnSerGlyAsn-295 297-CysLeuGluAsnGlySerAspThrAspIle-306 310-ThrAlaGluHisGlyLysLysProProLeuGluLysTyrHisAspGluThrPhe-327 331-TyrGlnAsnGluLysLeuGly-337 342-GlyPheSerAspGlyThrSerLeuThrGlyAspAspArgThrLeu-356 370-GlyAlaLysGlnGluGluGluLysArgLeu-379 383-LeuGlnGluArgAsnLeu-388 393-LeuHisAspSerIle-397 414-AlaPheAlaGluAsnLysArgGluGluAlaAlaGlu-425 433-GlyValGlnGluCysTyrGluAspValArgGlu-443 449-ArgThrLysIleSerAsnLysGluPheProGluAlaVal-461 480-TrpGluAsnGlySer-484 487-ProThrGlnAspGluGlnLeu-493 502-SerLeuSerAsnIleArgLysHisAlaArg-511 520-SerGluTyrGlyGlyArgPhe-526 530-IleGlnAspAsnGlyGlnGlyPheAspThrGluLysIleGlyGluProThrGlySerHis-549 555-MetGlnGluArgAlaLysArgIleArgAla-564 566-LeuGluIleArgSerGlnAlaGlnGlnGlyThr-576 581-ThrGlyAlaProLysGluSerLeuPro-589 Hydrophilic Regions - Hopp-Woods 48-ValIleGluGluAlaGlyAsn-54 68-GluGlySerProArgAlaGlnIle-75 78-GlnIleAlaGluPheGluLysSerLeuLysArgIleSerGln-91 128-AlaTyrArgArgProThrGln-134 152-GluAsnAlaGlyGluLys-157 193-GlnAlaLeuArgGluGlyAlaGluArgIleGlyGlnArgHisPhe-207 210-ProValProGluAspGlyThrProGluPheLysGlnValGly-223 235-ThrLeuTyrAspAspLeuGluGlyGlnValAlaGluGlnThrHisAsnLeuGluLysGlnAsnArg-256 264-ThrThrArgAspLeuHis-269 276-GlnAlaAlaGluGluPhe-281 300-AsnGlySerAspThrAspIle-306 312-GluHisGlyLysLysProProLeuGluLysTyrHisAspGluThrPhe-327 331-TyrGlnAsnGluLysLeuGly-337 347-ThrSerLeuThrGlyAspAspArgThrLeu-356 370-GlyAlaLysGlnGluGluGluLysArgLeu-379 383-LeuGlnGluArgAsnLeu-388 414-AlaPheAlaGluAsnLysArgGluGluAlaAlaGlu-425 436-GluCysTyrGluAspValArgGlu-443 450-ThrLysIleSerAsnLysGluPheProGluAlaVal-461 488-ThrGlnAspGluGlnLeu-493 502-SerLeuSerAsnIleArgLysHisAlaArg-511 532-AspAsnGlyGlnGlyPheAspThrGluLysIleGlyGluProThrGly-547 555-MetGlnGluArgAlaLysArgIleArgAla-564 566-LeuGluIleArgSerGlnAlaGln-573 582-GlyAlaProLysGluSerLeuPro-589 g562 AMPHI Regions - AMPHI 48-TrpSerLeuValSerAlaTrpMetValValIle-58 84-LeuGluThrThrValMetSerAlaValArgThrLeu-95 97-PheThrProTyrThrThrValAlaSerThrSer-107 116-ThrPhePheAlaProLeuSerArgTrp-124 133-AsnAlaProValHisSerMetThrLysSerThrProSerSerPheHis-148 184-ValSerAsnLeuValArgTrpAlaLeu-192 Antigenic Index - Jameson-WoIf 9-PheAsnSerGlyLysThrLysPro-16 32-ProLeuArgAlaArgArgArgSerLeuTrpArg-42 72-AlaThrGlyGluArgGlnLeuVal-79 105-SerThrSerSerProProGlyAlaGluMet-114 139-MetThrLysSerThrProSerSerPheHisGlySerSerAla-152 154-LeuArgValGluLysLysGlyIleLeuSerProLeuThr-166 168-ArgLeuProProSerTrpAspThrSerAlaSerLysArgProCysThr-183 Hydrophilic Regions - Hopp-Woods H-SerGlyLysThrLysPro-16 33-LeuArgAlaArgArgArgSerLeuTrp-41 72-AlaThrGlyGluArgGlnLeuVal-79 110-ProGlyAlaGluMet-114 140-ThrLysSerThrPro-144 154-LeuArgValGluLysLysGlyIle-161 176-SerAlaSerLysArgProCysThr-183 563g AMPHI Regions - AMPHI 24-ThrLysArgGluGlyLysSerCys-31 115-AsnGlnTyrAlaGlnPhe-120 159-ValAsnGlnIleAsnSerSerHisProSerGlnLeuAsnGlyTyrIleGlu-175 292-AlaAlaAsnValGlnAspMetAsnAsnThrAla-302 332-IleGlnAsnThrGlyLysLeuLeuSerAlaGly-342 457-AspAsnAlaValGlnGly-462 495-GlnMetAsnAsnIleGlyThr-501 571-AlaGlnArgIleHisAsnAlaGly-578 594-LeuHisAsnThrAsnGlu-599 616-TyrGluAlaPheGlyArg-621 642-SerAspHisLeuArgThrProAspGlyValAlaHisGluAsnTrp-656 673-ThrAlaProAlaLysIle-678 729-GlyLysLeuHisAsnTyrTrpArg-736 756-GluGluIleThrArg-760 771-SerHisSerLysAlaLeu-776 809-ProAsnSerPheThrProLeuPro-816 861-LeuHisLysArgLeuGlyAspGlyTyr-869 877-GluGlnIleAlaGluLeuThrGlyHisArgArgLeuAspGlyTyrGlnAsn-893 899-LysAlaLeuMetAsp-903 1002-ThrLeuAspAsnIleGlyGly-1008 1019-AlaThrGlnAspIleAsnAsnIleGlyGlyIleLeu-1030 1051-LysSerSerGlnAsn-1055 1106-GlnAlaGlyArgAspIle-llll 1135-GlySerThrAsnGluValGlySerSer-1143 1191-ValAspAspAlaSerLysHisThrGlyArg-1200 1215-SerHisHisGluThr-1219 1254-GlnAlaGlyAsnHisVal-1259 1269-GlnSerGluThrTyrHisGln-1275 1326-TyrGluGlnThrGly-1330 1388-SerThrGlnSerΞerLysGlnVal-1395 1416-TyrGlnThrGlyLysGlyAlaGlnAsnLeuAlaAsnGlyThrThrAsn-1431 1508-GluGlnSerAsnThrGluArgSerGln-1516 1542-GlyGlyAsnValGlyLysGlyTyr-1549 1692-SerAspIleGlnAsnTyrSerGln-1699 1718-LeuGlyGlnGlyAlaLys-1723 1761-IleAsnThrProLysAsnIle-1767 1796-ThrAspThrAlaGluArgHisSerGlySerLeuLysAsn-1808 1825-ValSerGlnAspPheSerLysAsnValGln-1834 1893-IleLeuAsnMetLeuAlaSerGlyLeuAlaGluProThr-1905 1925-GlyGlnHisPheLysAspLeuAlaGly-1933 1968-ProAlaGlyAlaLeu-1972 2006-SerAlaIleThrArgMetLeuGlyThrAla-2015 2032-PheGlnThrAlaSerAspPheAlaSerSerPheSerTyrProIleAsn-2047 Antigenic Index - Jameson-Wolf 1-MetAsnLysThrLeu-5 9-IlePheAsnArgLysArgGlyAlaVal-17 22-GluThrThrLysArgGluGlyLysSerCysAlaAspSerGlySerGlySer-38 48-ProThrHisSerLys-52 78-IleIleThrAspLysAlaAlaProLysThrGlnGln-89 122-ValGlyAsnArgGlyAlaIleLeuAsnAsnSerArgSerAsnThrGlnThr-138 147-AsnProTrpLeuThrArgGlyGluAlaArgVal-157 162-IleAsnSerSerHisProSerGlnLeuAsnGly-172 174-IleGluValGlyGlyArgArgAlaGluVal-183 20O-AsnAlaSerArgAlaThrLeu-206 208-ThrGlyGlnProGlnTyrGlnAlaGlyAspPheSerGlyPheLysIleArgGlnGlyAsnAla-228 234-GlyLeuAspAlaArgAspThrAspPhe-242 261-AlaGlyIleArgAsnGlnGlyGlnLeu-269 279-AspAlaAsnGlyArgLeuValAsn-286 296-GlnAspMetAsnAsnThrAlaGluHisLysValAsnIleArg-309 311-GlnAlaPheGluAsnSerGlyThrAlaVal-320 322-GlnGlnGlyThrGlnIleHis-328 330-GlnSerIleGlnAsnThrGlyLysLeu-338 340-SerAlaGlyThrGluAspLeuAlaVal-348 351-SerLeuAsnAsnGlnAsnGlyGluIleAlaThrAsn-362 366-IleIleHisAspGlyGlnGlnSer-373 379-AsnThrAsnGlyThrIleGlnSerGlyArgAspValAlaIle-392 395-LysSerLeuSerAsnAsnGlyThrLeuAlaAlaAspAsnLysLeuAspIleAlaLeu-413 415-AspAspPheTyrValGluArgLysIleValAlaGlyAsnGluLeu-429 431-LeuSerThrArgGlySerLeuLysAsnSerHisThr-442 444-GlnAlaGlyLysArglleArglleLysAlaAsnAsnLeuAspAsn-458 463-AsnIleGlnSerGlyGlyThrThrAspIleGlyThrGlnHisAsnLeuThrAsnArgGlyLeuIleAspGly GlnGlnThrLysIleGln-492 513-AlaThrArgLeuAspAsnGlnAspGluAsnGlyThrGly-525 529-AlaAlaArgGluAsnLeu-534 540-GlnLeuAsnAsnArgGluAsnSerLeu-548 559-GlyAlaLeuAspThrAsnAspGlnAlaThrGlyLysAlaGlnArgIleHisAsnAlaGlyAla-579 583-AlaAlaGlyLysMetArgLeuGlyValGluLysLeuHisAsnThrAsnGluHisLeuLys-602 607-GluThrGlyArgGluArgIleValAsp-615 623-GluLeuLeuArgGluGlyThrGlnHis-631 638-TyrAsnAsnGluSerAspHisLeuArgThrProAspGlyValAlaHis-653 657-HisLysTyrAspTyrGluLysValThrGlnGluThrGlnVal-670 680-AlaGlySerAspLeuIleIleAspSerLysAlaValPheAsnSerAspSerArgIle-698 707-GlnThrGluLysAspGlyLeuHisAsnGluGlnThrPheGlyGluLysLysValPheSerGluAsnGlyLys LeuHisAsn-733 735-TrpArgAlaArgArgLysGlyHisAspGluThrGlyHisArgGluGlnAsnTyrThrLeuProGluGluIle ThrArgAspIleSerLeu-764 770-GluSerHisSerLysAlaLeuSerArgHisAlaProSerGlnGlyThrGluLeuProGlnSerAsnArgAsp AsnIleArgThrAlaLysSerAsnGlyIle-803 825-ProAlaAsnLysGlyTyrLeuValGluThrAspProArgPheAlaAsn-840 854-LeuLysLeuAspProAsnAsnLeuHisLysArgLeuGlyAspGlyTyrTyrGluGlnArgLeuIleAsn-87 6 883-ThrGlyHisArgArgLeuAspGlyTyrGlnAsnAspGluGluGlnPheLysAlaLeuMetAspAsnGlyAla ThrAlaAlaArgSerMetAsn-913 922-AlaGluGlnAlaAla-926 938-LysGluValLysLeuProAspGlyGlyThr-947 959-ValLysAsnGlyGlyIleAspGlyLysGly-968 982-GlySerLeuLysAsnSerGlyThrIleAlaGlyArgAsnAla-995 999-AsnThrAspThrLeuAspAsnl1eGlyGly-1008 lOlO-IleHisAlaGlnLysSerAlaVal-1017 1040-AlaGlyAsnAsnIleAsnAsnGlnSerThrAlaLysSerSerGlnAsnAlaGlnGlySer-1059 1072-ThrGlyLysGluLysGlyVal-1078 1083-AlaGlyLysAspIleAsnlle-1089 1094-IleSerAsnGlnSerAspGlnGlyGlnThrArgLeuGlnAlaGlyArgAspIleAsnLeuAspThrValGl nThrGlyLysTyrGlnGluIleHisPheAspAlaAspAsnHisThrlleArgGlySerThrAsnGluValGlySer SerIleGlnThrLysGlyAspVal-1150 1155-GlyAsnAsnLeuAsnAlaLysAlaAlaGluValGlySerAlaLysGlyThr-1171 1175-TyrAlaLysAsnAspIleThrIle-1182 1190-GlnValAspAspAlaSerLysHisThrGlyArgSerGlyGlyGlyAsnLys-1206 1208-ValIleThrAspLysAlaGlnSerHisHisGluThrAlaGlnSerSerThrPheGluGlyLysGln-1229 1233-GlnAlaGlyAsnAspAlaAsn-1239 1245-ValIleSerAspAsnGlyThrArgIleGlnAla-1255 1262-GlyThrThrGlnThrGlnSerGlnSerGluThrTyrHisGlnThrGlnLysSerGlyLeu-1281 1291-GlySerLysThrAsnThrGlnGluAsnGlnSerGlnSerAsnGluHisThrGlySerThrValGlySerLe uLysGlyAspThrThrIle-1320 1324-LysHisTyrGluGlnThrGlySerAsnValSerSerProGluGlyAsnAsnLeu-1341 1354-AsnGlnLeuAsnSerLysThrThrGlnThrTyrGluGlnLysGlyLeu-1369 1379-ArgPheGlyThrThrSerAspCysArgSerThrGlnSerSerLysGlnValGlyGlnSerLysAsnAspAr gValAsnAla-1405 1415-AlaTyrGlnThrGlyLysGlyAlaGlnAsnLeuAlaAsnGlyThrThrAsnAlaLys-1433 1441-TyrGlyGluGlnGlnAsnArgGlnThrThrGln-1451 1460-SerGlnIleGlnAlaGlyGlyLysThr-1468 1470-LeuTyrCysArgArgCysGlyGluGlnSerAsn-1480 1487-GlyValSerGlyArgAlaGlyThr-1494 1496-LeuIleAlaAspLysGlnIle-1502 1506-SerAlaGluGlnSerAsnThrGluArgSerGlnAsnLysSerAlaGlyTrpAsn-1523 1543-GlyAsnValGlyLysGlyTyrGlyTyrGlyAspSerValThrHisArgHisSerHisIleGlyAspLysGl ySerGln-1568 1572-GlnSerGlyGlyAspThrIleIle-1579 1582-AlaGlnValArgGlyLysGlyValGlnValAsnAlaLysAsn-1595 1600-SerValGlnAspArgGluThrTyrGlnSerLysGlnGlnAsnAlaGlyAla-1616 1626-AlaSerGlyAspTyrSerGlnSerLysIleArgAlaAspHis-1639 1641-SerValThrGluGlnSerGlyIleTyrAlaGlyGluAspGlyTyrGln-1656 1660-GlyAsnHisThrGlyLeuLysGlyGlyIle-1669 1673-SerGlnSerAlaLysAspLysGlyLysAsnArgPheSerThrGlyThrLeuAlaGlySerAspIleGlnAs nTyrSerGlnTyrGluGlyLysSerPheGly-1706 1713-ValSerGlyLysThrLeuGlyGlnGlyAlaLysAsnLysProGlnAspLysHisLeu-1731 1734-IleAlaAspLysAsnGlyAlaSerSer-1742 1745-GlyTyrGlySerAspSerAspSerGlnSerSerIleThrLysSerGlyIleAsnThrProLysAsnIleGl nIleThrAspGluAlaAlaGln-1775 1778-LeuThrGlyLysIleAlaAlaGlnThrLysAlaAspIleAspThrAsnValThrThrAspThrAlaGluAr gHisSerGlySerLeuLysAsnllePheAspLysAspArgValGlnSerGluLeuAspLeuGlnArgThrValSer GlnAspPheSerLysAsnValGlnGlnThrAsnThrGluIle-1840 1842-GlnHisLeuAspLysLeuLysAlaAspLysGluAlaAlaGluThrAlaAla-1858 1863-AlaAsnGlyAspMetGluThrAlaLysArgLysAlaHisGluAlaGlnAspAlaAlaAlaLysAlaAspAs nTrpGlnGln-1889 1899-SerGlyLeuAlaGluProThrGlnSerGly-1908 1915-ThrAlaSerProAspValSer-1921 1927-HisPheLysAspLeuAlaGlyGlnAsnAlaAsnGlyLysLeuThrAlaSerGlnGluThr-1946 1963-XxxGlyAsnAsnAlaPro-1968 1973-GlyAlaGlyGlySerGluAlaAla-1980 1988-LeuTyrGlyLysGlyAspGlyGlySerLeuAsnAlaGluGluLysGluThrVal-2005 2017-GlyAlaAlaGluGlyAsnSerSerAlaAspAla-2027 2034-ThrAlaSerAspPheAlaSerSerPheSerTyr-2044 Hydrophilic Regions - Hopp-Woods 10-PheAsnArgLysArgGlyAla-16 22-GluThrThrLysArgGluGlyLysSerCysAlaAspSerGlySer-36 78-IleIleThrAspLysAlaAlaProLysThrGlnGln-89 131-AsnSerArgSerAsnThr-136 153-GlyGluAlaArgVal-157 176-ValGlyGlyArgArgAlaGluVal-183 235-LeuAspAlaArgAspThrAspPhe-242 261-AlaGlyIleArgAsn-265 296-GlnAspMetAsnAsnThrAlaGluHisLysValAsnIle-308 311-GlnAlaPheGluAsnSerGly-317 342-GlyThrGluAspLeuAla-347 355-GlnAsnGlyGluIleAlaThr-361 385-GlnSerGlyArgAspValAlaIle-392 403-LeuAlaAlaAspAsnLysLeuAspIleAlaLeu-413 417-PheTyrValGluArgLysIleValAla-425 435-GlySerLeuLysAsn-439 444-GlnAlaGlyLysArgIleArgIleLysAlaAsnAsnLeu-456 468-GlyThrThrAspIleGlyThr-474 487-GlnGlnThrLysIleGln-492 514-ThrArgLeuAspAsnGlnAspGluAsnGlyThr-524 529-AlaAlaArgGluAsnLeu-534 540-GlnLeuAsnAsnArgGluAsnSer-547 561-LeuAspThrAsnAspGlnAlaThrGlyLysAlaGlnArgIleHis-575 583-AlaAlaGlyLysMetArgLeuGlyValGluLysLeuHisAsnThrAsnGluHisLeuLys-602 607-GluThrGlyArgGluArgIleValAsp-615 623-GluLeuLeuArgGluGlyThrGlnHis-631 640-AsnGluSerAspHisLeuArgThrProAspGlyValAla-652 659-TyrAspTyrGluLysValThrGln-666 684-LeuIleIleAspSerLysAla-690 694-SerAspSerArgIle-698 707-GlnThrGluLysAspGlyLeuHisAsn-715 717-GlnThrPheGlyGluLysLysValPheSerGluAsnGlyLys-730 736-ArgAlaArgArgLysGlyHisAspGluThrGlyHisArgGluGlnAsn-751 756-GluGluIleThrArgAspIleSer-763 771-SerHisSerLysAlaLeuΞerArgHisAlaPro-781 783-GlnGlyThrGluLeuProGlnSerAsnArgAspAsnIleArgThrAlaLysSerAsnGly-802 830-TyrLeuValGluThrAspProArgPheAlaAsn-840 854-LeuLysLeuAspPro-858 860-AsnLeuHisLysArgLeuGly-866 883-ThrGlyHisArgArgLeuAspGlyTyrGlnAsnAspGluGluGlnPheLysAlaLeuMet-902 905-GlyAlaThrAlaAlaArg-910 922-AlaGluGlnAlaAla-926 938-LysGluValLysLeuProAspGlyGlyThr-947 959-ValLysAsnGlyGlyI1eAspGlyLysGly-968 982-GlySerLeuLysAsn-986 lOlO-IleHisAlaGlnLysSerAlaVal-1017 1048-SerThrAlaLysSerSerGlnAsnAlaGlnGly-1058 1073-GlyLysGluLysGlyVal-1078 1083-AlaGlyLysAspIleAsn-1088 1096-AsnGlnSerAspGlnGlyGlnThrArgLeuGlnAlaGlyArgAspIleAsnLeu-1113 1125-HisPheAspAlaAspAsnHisThrIleArgGlySerThrAsnGluValGlySer-1142 1144-IleGlnThrLysGlyAspVal-1150 1158-LeuAsnAlaLysAlaAlaGluValGlySerAlaLysGly-1170 1176-AlaLysAsnAspIle-1180 1190-GlnValAspAspAlaSerLysHisThrGlyArgSerGlyGlyGly-1204 1208-ValIleThrAspLysAlaGlnSerHisHisGluThrAlaGln-1221 1223-SerThrPheGluGlyLysGln-1229 1249-AsnGlyThrArgIleGlnAla-1255 1267-GlnSerGlnSerGluThr-1272 1276-ThrGlnLysSerGlyLeu-1281 1292-SerLysThrAsnThrGlnGluAsnGlnSerGlnSerAsnGluHisThrGly-1308 1314-LeuLysGlyAspThr-1318 1324-LysHisTyrGluGlnThrGly-1330 1334-SerSerProGluGly-1338 1356-LeuAsnSerLysThrThrGln-1362 1364-TyrGluGlnLysGly-1368 1384-SerAspCysArgSerThrGlnSerSerLysGlnValGlyGlnSerLysAsnAspArgValAsn-1404 1417-GlnThrGlyLysGlyAlaGln-1423 1443-GluGlnGlnAsnArgGlnThrThr-1450 1474-ArgCysGlyGluGlnSerAsn-1480 1488-ValSerGlyArgAlaGly-1493 1497-IleAlaAspLysGlnIle-1502 1506-SerAlaGluGlnSerAsnThrGluArgSerGlnAsnLys-1518 1560-SerHisIleGlyAspLysGlySer-1567 1582-AlaGlnValArgGlyLysGlyVal-1589 1600-SerValGlnAspArgGluThrTyrGlnSerLysGlnGlnAsn-1613 1628-GlyAspTyrSerGlnSerLysIleArgAlaAspHis-1639 1650-AlaGlyGluAspGlyTyrGln-1656 1674-GlnSerAlaLysAspLysGlyLysAsnArgPheSer-1685 1700-TyrGluGlyLysSer-1704 1717-ThrLeuGlyGlnGlyAlaLysAsnLysProGlnAspLysHisLeu-1731 1734-IleAlaAspLysAsnGlyAla-1740 1748-SerAspSerAspSerGlnSerSerIleThr-1757 1768-GlnIleThrAspGluAlaAlaGln-1775 1786-ThrLysAlaAspIleAspThr-1792 1794-ValThrThrAspThrAlaGluArgHisSerGlySerLeu-1806 1808-AsnIlePheAspLysAspArgValGlnSerGluLeuAspLeuGlnArgThrValSer-1826 1836-ThrAsnThrGluIle-1840 1842-GlnHisLeuAspLysLeuLysAlaAspLysGluAlaAlaGluThrAlaAla-1858 1865-GlyAspMetGluThrAlaLysArgLysAlaHisGluAlaGlnAspAlaAlaAlaLysAlaAspAsn-1886 1901-LeuAlaGluProThrGln-1906 1927-HisPheLysAspLeuAlaGly-1933 1936-AlaAsnGlyLysLeuThrAlaSerGlnGluThr-1946 1975-GlyGlySerGluAlaAla-1980 1991-LysGlyAspGlyGlySerLeuAsnAlaGluGluLysGluThrVal-2005 2017-GlyAlaAlaGluGlyAsnSerSerAla-2025 g565-2 AMPHI Regions - AMPHI 50-AlaThrCysThrArgAlaMetSerLysSer-59 66-SerSerTrpAlaArg-70 103-AspPheMetSerGlnLeuAspLeuThr-lll 139-CysSerAsnSerGlyGluThrIleSerSerCysProAlaMetAlaSerIleThrLysProAsn-159 184-AlaAsnThrThrAsnAlaPheAsnThr-192 Antigenic Index - Jameson-Wolf l-MetAspΞerThrLeuSerLysThrCys-9 23-PheAlaArgProArgProAlaAlaSerAsnThrSerLeu-35 37-PheAlaSerProAsnAspThrGlySer-45 55-AlaMetSerLysSerSerAlaLysTyrGly-64 67-SerTrpAlaArgThrArgProThrValCysProProLeuProLysProThrIle-84 86-ThrXxxSerAspLeu-90 97-MetLeuCysArgSerSerAspPheMetSer-106 109-AspLeuThrLysArgProThrSerAlaSerLeuProProLysArgLysGlyAlaIle-127 129-IleAspSerArgThrAlaAla-135 139-CysSerAsnSerGlyGluThrIleSer-147 155-1leThrLysProAsnSerProProCysAlaArgTyr-166 170-LeuArgLeuSerProThrGlu-176 194-SerIleAlaAsnSerIleAsnThrCysArgGlnProPro-206 Hydrophilic Regions - Hopp-Woods 24-AlaArgProArgProAlaAla-30 39-SerProAsnAspThrGlySer-45 55-AlaMetSerLysSerSerAla-61 69-AlaArgThrArgPro-73 100-ArgSerSerAspPhe-104 109-AspLeuThrLysArgProThrSer-116 119-LeuProProLysArgLysGlyAlaIle-127 129-IleAspSerArgThr-133 141-AsnSerGlyGluThrIleSer-147 156-ThrLysProAsnSer-160 g566 AMPHI Regions - AMPHI 52-GlyPheValGlyAspPheHisAlaPhe-60 Antigenic Index - Jameson-Wolf 36-ProAsnCysGlyAlaAspGlyThrGlyGlyLysGlyHisAla-49 61-AlaValGlyGlyGluGluGlyGlyVal-69 77-AlaAspGlyGlyLysAlaAspGlyGlyArgIleAlaArg-89 105-AlaAlaGluArgAlaGlyAspAspPheAla-114 Hydrophilic Regions - Hopp-Woods 39-GlyAlaAspGlyThrGlyGlyLysGlyHisAla-49 63-GlyGlyGluGluGlyGlyVal-69 78-AspGlyGlyLysAlaAspGlyGlyArgIleAlaArg-89 105-AlaAlaGluArgAlaGlyAspAspPheAla-114 g567 AMPHI Regions - AMPHI 54-GluLeuValGlnGluIleAlaArgGluVal-63 68-AlaLeuLysAlaVal-72 110-TyrAlaLeuGluGlyIleSerAspLeuIleAlaThrValArgLysIleArgGln-127 136-ThrGlyIleValArg-140 151-AlaGluValSerGluGlnLeuArgSerHisPheGlyAspLeuLeu-165 170-IleProArgAsnIleArgLeuAla-177 Antigenic Index - Jameson-Wolf l-MetArgArgArgAlaAlaAlaSerThrArgArgValCysSerProAlaPhe-17 24-MetArgThrCysSerArgArgArgTyrAlaAlaLysArgAlaAspThr-39 51-AlaGluIleGluLeu-55 57-GlnGluIleAlaArgGluValArgLeuLysAsnAlaLeu-69 71-AlaValAlaGluAspTyrAsp-77 83-CysProProSerLeu-87 123-ArgLysIleArgGlnAlaValAsnProAspLeuAspIle-135 141-ThrMetTyrAspSerArgSerArgLeuValAlaGluValSerGluGlnLeuArgSerHisPheGlyAspLeu -164 169-AlaIleProArgAsnIleArgLeuAlaGluAlaProSerHisGly-183 191-AlaGlnAlaLysGlyAlaLys-197 204-AspGluLeuAlaAlaArgValSerGlyLys-213 Hydrophilic Regions - Hopp-Woods l-MetArgArgArgAlaAlaAlaSerThrArgArgValCys-13 26-ThrCysSerArgArgArgTyrAlaAlaLysArgAlaAspThr-39 51-AlaGluIleGluLeu-55 57-GlnGluIleAlaArgGluValArgLeuLysAsnAlaLeu-69 71-AlaValAlaGluAspTyrAsp-77 123-ArgLysIleArgGln-127 131-ProAspLeuAspIle-135 142-MetTyrAspSerArgSerArgLeuValAlaGluValSerGluGlnLeuArg-158 172-ArgAsnIleArgLeuAlaGlu-178 191-AlaGlnAlaLysGlyAlaLys-197 204-AspGluLeuAlaAla-208 g568-2 AMPHI Regions - AMPHI 32-AsnIlePheArgArgIle-37 49-LysAlaCysLysAsn-53 71-GluLysAlaAsnThrValArgTyr-78 82-SerLeuAlaGlnCysPheThr-88 112-ArgProLeuProSerIleIleThrAla-120 154-ProXxxAspLeuAsn-158 177-LeuValGlyGlnPheLeuAsnArgLeuPhe-186 200-GluGluPhePheAspValValVal-207 227-AspPheAsnGlnValPheAlaAlaPheLeu-236 241-HisArgHisAlaAspGlnIleAlaAspSerCysArgValGlnSerGln-256 Antigenic Index - Jameson-Wolf 12-LysAlaSerAlaSerSerIlePro-19 21-ArgIleCysArgLeuLysArgSerArgLeuProAsnIlePhe-34 39-PheSerCysArgArgArgThrCysPheCysLysAlaCysLysAsnSerProIleArgAsnGluThrSerSerS erGlyArgArgGlnPheSerValGluLysAlaAsnThr-75 91-SerAsnAlaSerLysProArgLeu-98 102-IleArgGlyArgLysArgPhePheAla-llO 141-PheArgGlySerAlaPheLysCysArgLeuAsnAlaAlaProXxxAspLeuAsnArg-159 166-GlySerGlnAsnLeu-170 213-ValAlaAspArgAspAlaSer-219 237-GlyGlnHisGlyHisArgHisAlaAspGlnIleAlaAspSerCysArgValGlnSerGln-256 Hydrophilic Regions - Hopp-Woods 21-Argl1eCysArgLeuLysArgSerArgLeu-30 41-CysArgArgArgThrCysPhe-47 49-LysAlaCysLysAsnSerProIleArgAsnGluThrSerSerSerGlyArgArgGlnPheSerValGluLysA laAsnThr-75 93-AlaSerLysProArgLeu-98 102-IleArgGlyArgLysArgPhePheAla-llO 144-SerAlaPheLysCysArgLeu-150 152-AlaAlaProXxxAspLeuAsnArg-159 213-ValAlaAspArgAspAlaSer-219 239-HisGlyHisArgHisAlaAspGlnIleAlaAspSerCysArgVal-253 g569-2 AMPHI Regions - AMPHI 29-AlaAlaPheCysGlyLeuIleAlaLeuThrAlaLeuTrpGluTyrAlaArgMetAlaGlyLeuCysLys-51 86-PheTrpLeuAlaValMetPro-92 161-IleAlaArgAlaIleSerProGlyLysSerTrpGluGlyAlaIle-175 203 -ThrValLeuIleGlyLeu-208 210-LeuThrValValSerValCysGlyAspLeuLeuGluSerTrpLeuLys-225 Antigenic Index - Jameson-Wolf 50-CysLysThrGluThrAsnHis-56 98-LysTrpArgLeuAsnGlyGlyTrp-105 124-SerLeuArgProHisProAspAspAlaLeu-133 154-LysAlaLeuGlyLysHisLysIleAlaArg-163 165-IleSerProGlyLysSerTrpGlu-172 227-AlaAlaGlyIleLysAspSerSerAsnLeuLeuProGlyHis-240 242-GlyValPheAspArgThrAspSer-249 Hydrophilic Regions - Hopp-Woods 50-CysLysThrGluThr-54 127-ProHisProAspAspAlaLeu-133 155-AlaLeuGlyLysHisLysIleAlaArg-163 227-AlaAlaGlyIleLysAspSerSerAsn-235 243-ValPheAspArgThrAspSer-249 g570 AMPHI Regions - AMPHI 6-ArgAlaPheAlaAlaAlaLeuIleGlyLeu-15 22-HisAlaAspThrPheGlnLysIleGlyPheIleAsn-33 43-GlnAlaArgAsnIleGlnLysThrLeuAspGly-53 60-AspGluLeuGlnLysLeuGln-66 81-LeuLysAspAlaLysLys-86 91-GluLysTrpArgGlyLeuValGluAlaPheArg-101 122-LeuGlnGlnAsnAlaAsnArgValIleValLysIle-133 Antigenic Index - Jameson-Wolf 33-AsnThrGluArgIleTyrLeuGluSerLysGlnAlaArgAsnIleGlnLysThrLeuAspGlyGluPheSerA laArgGlnAspGluLeuGlnLysLeuGlnArgGluGlyLeuAspLeuGluArgGlnLeuAlaGlyGlyLysLeuLy sAspAlaLysLysAlaGlnAlaGluGluLysTrpArgGly-95 99-AlaPheArgLysLysGlnAlaGlnPheGluGluAspTyrAsnLeuArgArgAsnGluGluPheAla-120 123-GlnGlnAsnAlaAsnArgVal-129 133-IleAlaLysGlnGluGlyTyrAspValIle-142 150-AsnThrGlnTyrAspValThrAspSerValIleLysGluMetAsnAlaArg-166 Hydrophilic Regions - Hopp-Woods 37-IleTyrLeuGluSerLysGlnAlaArgAsnIleGlnLysThrLeuAspGlyGluPheSerAlaArgGlnAspG luLeuGlnLysLeuGlnArgGluGlyLeuAspLeuGluArgGlnLeuAla-77 79-GlyLysLeuLysAspAlaLysLysAlaGlnAlaGluGluLysTrpArgGly-95 99-AlaPheArgLysLysGlnAlaGlnPheGluGluAspTyrAsnLeuArgArgAsnGluGluPheAla-120 133-IleAlaLysGlnGluGlyTyr-139 154-AspValThrAspSerValIleLysGluMetAsnAlaArg-166 g571 AMPHI Regions - AMPHI 10-ValValThrValPheGlyGlyGlyIleGlySerAlaVal-22 58-AlaAlaValAlaAspPhePheAlaVal-66 89-ValGluValPheLysGlu-94 Antigenic Index - Jameson-Wolf 30-LysGlnAlaGlnAlaAspGly-36 40-PheArgThrGlyHisArgGluGluGlnLeuGlyGlyAspVal-53 72-ArgAlaGluArgAlaAla-77 91-ValPheLysGluGlyAspPhe-97 105-ArgAsnAlaAspPheAlaAlaGluHisGlnArgGluGlyPheAla-119 Hydrophilic Regions - Hopp-Woods 30-LysGlnAlaGlnAlaAsp-35 42-ThrGlyHisArgGluGluGlnLeuGly-50 72-ArgAlaGluArgAlaAla-77 91-ValPheLysGluGlyAspPhe-97 105-ArgAsnAlaAspPheAlaAlaGluHisGlnArgGluGlyPheAla-119 g572 AMPHI Regions - AMPHI 10-LeuProSerAlaLeuAla-15 61-GlnValLeuProArgAspTyrThrAspArgLeuAsn-72 94-SerThrPheAspSerIleThrPro-101 154-IleHisSerMetValArg-159 183-GlyLeuProGluArgIleAspSerGly-191 200-LeuSerAlaLeuThr-204 Antigenic Index - Jameson-Wolf 18-GlnLysGlyLysThr-22 26-AlaAsnLysGluThrLeu-31 41-ThrAlaArgAlaAsnGly-46 51-ProValAspSerGluHis-56 63-LeuProArgAspTyrThrAspArgLeuAsnGluHisGlyIleAsp-77 97-AspSerIleThrProGluGlnAlaValLysHisProAsnTrpArgMetGlyArgLysIleSerValAspSer- 120 122-ThrMetAlaAsnLysGlyLeuGluLeu-130 138-AsnCysProProAspLysLeuGluVal-146 158-ValArgTyrArgAspGlySerVal-165 170-GlyAsnProAspMetArgThr-176 184-LeuProGluArgIleAspSerGlyValGlyLysLeuAsp-196 205-PheGlnLysProAspPheGlyArg-212 224-AsnAlaGlyGlyAla-228 Hydrophilic Regions - Hopp-Woods 27-AsnLysGluThrLeu-31 41-ThrAlaArgAlaAsnGly-46 52-ValAspSerGluHis-56 66-AspTyrThrAspArgLeuAsnGluHisGly11e-76 lll-ArgMetGlyArgLysIleSerVal-118 126-LysGlyLeuGluLeu-130 140-ProProAspLysLeuGlu-145 158-ValArgTyrArgAspGlySer-164 170-GlyAsnProAspMetArgThr-176 184-LeuProGluArgIleAspSerGlyValGlyLyεLeuAsp-196 206-GlnLysProAspPheGly-211 g574 AMPHI Regions - AMPHI 6-ProAsnSerLeuLysLys-ll 47-LeuLysGlnAlaLysSerIleProSerGlyPheTyrLysSerLeuAspAlaLeuValAspArgAsnSerGlyA rgAlaAlaArgGluLeuAlaGluValValAsp-81 94-GlyLysLeuTyrArgGln-99 113-MetLeuAspSerProAspThr-119 175-GluLysAlaValGlu-179 218-AsnValGlyLysAlaLeuGluAlaAsnLysLysCys-229 246-PheProAlaAlaValGluAlaTyrAlaAlaIleGlu-257 266-MetValGlyGluLysLeuTyrGluAlaTyrAla-276 281-ProGluGluGlyLeuAsnArgLeuThrGlyTyrMetGlnThrPheProGluLeuAspLeu-300 332-AsnGlyValTyrArg-336 357-ArgSerValIleGlyArgGlnLeuGlnArgSer-367 Antigenic Index - Jameson-Wolf 7-AsnSerLeuLysLysAlaAspMetAspAsn-16 45-ThrValLeuLysGlnAlaLysSerIleProSerGlyPheTyrLysSerLeuAspAlaLeuValAspArgAsnS erGlyArgAlaAlaArgGluLeuAlaGluValValAspGlyArgProGlnSerTyrAsp-88 96-LeuTyrArgGlnArgGlyGluAsnAspLysAlaIleAsnIleHisArgThrMetLeuAspSerProAspThrV alGlyGluLysArgAlaArgVal-127 135-TyrGlnSerAlaGlyLeuValAspArgAlaGlu-145 151-LeuGlnAspGlyGluMetAlaArgGluAlaArgGln-162 168-TyrGlnGlnAspArgAspTrpGluLysAlaValGlu-179 185-SerHisAspGluGlnThrTyr-191 210-SerAsnPheAspAlaAlaArg-216 221-LysAlaLeuGluAlaAsnLysLysCysThrArg-231 238-AspIleGluHisArgGlnGlyAsn-245 277-AlaGlnGlyLysProGluGluGlyLeuAsnArgLeuThrGlyTyr-291 309-LeuLeuLeuLysGlyGluLysGluAlaAla-318 323-GluLeuValArgArgLysProAspLeuAsnGly-333 341-LysLeuSerAspLeuAspProAlaTrpLysAlaAspAlaAspMetMetArg-357 368-ValMetTyrArgCysArgAsnCysHisPheLys-378 386-CysProAlaCysAsnLysTrpGlnThrPheThrProAsnLysIleGluVal-402 Hydrophilic Regions - Hopp-Woods 7-AsnSerLeuLysLysAlaAspMetAspAsn-16 45-ThrValLeuLysGlnAlaLysSerIle-53 62-AspAlaLeuValAspArgAsnSerGlyArgAlaAlaArgGluLeuAlaGluValValAspGlyArgProGlnS er-86 96-LeuTyrArgGlnArgGlyGluAsnAspLysAlal1eAsn-108 112-ThrMetLeuAspSerProAspThrValGlyGluLysArgAlaArgVal-127 140-LeuValAspArgAlaGlu-145 152-GlnAspGlyGluMetAlaArgGluAlaArgGln-162 169-GlnGlnAspArgAspTrpGluLysAlaValGlu-179 185-SerHisAspGluGlnThrTyr-191 211-AsnPheAspAlaAlaArg-216 221-LysAlaLeuGluAlaAsnLysLysCysThrArg-231 238-AspIleGluHisArgGlnGlyAsn-245 279-GlyLysProGluGluGlyLeuAsn-286 309-LeuLeuLeuLysGlyGluLysGluAlaAla-318 323-GluLeuValArgArgLysProAspLeu-331 341-LysLeuSerAspLeuAspPro-347 349-TrpLysAlaAspAlaAspMetMetArg-357 368-ValMetTyrArgCysArgAsnCysHis-376 398-AsnLysIleGluVal-402 g575 AMPHI Regions - AMPHI 31-ProValArgGlnValArg-36 93-TrpArgSerValAlaGluAlaGlyValSer-102 104-ThrAlaGlyLeuGlySerGlyArgThrAlaGlyPheSerAlaPheAlaSerGlyAla-122 124-ThrPheAlaSerGlyPheSerThrGly-132 149-GlySerAspGlyMetAspAlaValSerAlaLeu-159 Antigenic Index - Jameson-Wolf 3 -CysLeuArgArgGlnAlaAlaArgCysThrAsnArgArgThrAspArgGInThrVa1-21 27-LeuArgGlnLysProValArgGlnValArgGlnArgValArgArg-41 49-GlnGlnValArgLysArgCysTyrArgPheArgArgSerAlaCysArgTrpGlnLysArgArgLeuLeuGlyG lyAlaAspSerAlaAlaVal-79 89-ThrGlyProGlyTrp-93 100-GlyValSerAspThrAlaGlyLeuGlySerGlyArgThrAla-113 129-PheSerThrGlyPheSerThr-135 147-LeuAspGlySerAspGlyMetAsp-154 Hydrophilic Regions - Hopp-Woods 3-CysLeuArgArgGlnAlaAlaArgCysThrAsnArgArgThrAspArgGlnThrVal-21 27-LeuArgGlnLysProValArgGlnValArgGlnArgValArgArg-41 50-GlnValArgLysArgCysTyrArgPheArgArgSerAlaCysArgTrpGlnLysArgArgLeuLeuGly-72 74-AlaAspSerAlaAlaVal-79 148-AspGlySerAspGlyMetAsp-154 g576-l AMPHI Regions - AMPHI 31-AlaSerGluProAlaAlaAla-37 46-SerIleGlySerThr-50 63-GlyArgSerLeuLysGlnMetLys-70 82-ThrAspAlaMetGln-86 102-GlnGluValMetMetLysPheLeuGlnGluGlnGlnAlaLysAlaValGluLysHis-120 140-AlaLysAspGlyValLysThrThr-147 200-GlnValIleProGlyTrpThrGluGlyValArgLeuLeuLysGluGly-215 Antigenic Index - Jameson-Wolf 20-AlaCysGlyLysLysGluAlaAlaPro-28 30-ΞerAlaSerGluProAlaAla-36 40-AlaGlnGlyAspThrSerSerIleGlySerThrMetGlnGln-53 61-AspIleGlyArgSerLeuLysGlnMetLysGluGlnGlyAlaGluIleAspLeu-78 89-TyrAspGlyLysGluIleLysMetThrGluGluGlnAlaGln-102 109-LeuGlnGluGlnGlnAlaLysAlaValGluLysHisLysAlaAspAlaLysAlaAsnLysGluLysGlyGlu AlaPheLeuLysGluAsnAlaAlaLysAspGlyValLysThrThrAlaSerGlyLeu-151 154-LysIleThrLysGlnGlyGluGlyLysGlnProThrLysAspAspIleVal-170 173-GluTyrGluGlyArgLeuIleAsp-180 183-ValPheAspSerSerLysAlaAsnGlyGlyPro-193 203-ProGlyTrpThrGlu-207 209-ValArgLeuLeuLysGluGlyGlyGlu-217 224-SerAsnLeuAlaTyrArgGluGlnGlyAlaGlyGluLysIleGlyPro-239 253-GlyAlaProGluAsnAlaProAlaLysGlnProAspGlnValAspIleLysLysValAsn-272 Hydrophilic Regions - Hopp-Woods 21-CysGlyLysLysGluAlaAlaPro-28 30-SerAlaSerGluProAlaAla-36 40-AlaGlnGlyAspThrSerSer-46 61-AspIleGlyArgSerLeuLysGlnMetLysGluGlnGlyAlaGluIleAspLeu-78 89-TyrAspGlyLysGluIleLysMetThrGluGluGlnAlaGln-102 112-GlnGlnAlaLysAlaValGluLysHisLysAlaAspAlaLysAlaAsnLysGluLysGlyGluAlaPheLeu LysGluAsnAlaAlaLysAspGlyValLysThrThrAla-148 155-IleThrLysGlnGlyGluGlyLysGlnProThrLysAspAspIleVal-170 173-GluTyrGluGlyArgLeuIleAsp-180 185-AspSerSerLysAlaAsnGly-191 209-ValArgLeuLeuLysGluGlyGlyGlu-217 227-AlaTyrArgGluGlnGlyAlaGlyGluLysIleGlyPro-239 253-GlyAlaProGluAsnAlaProAlaLysGlnProAspGlnValAspIleLysLysValAsn-272 g577 AMPHI Regions - AMPHI 8-GlyLysIleValGlyAsnArgIleLeuArgMetProSerGluHis-22 26-PheTyrProLysProCysLysSerPheLysLeuThr-37 62-ThrValIleLysIleIle-67 104-AlaPheValValGlyIle-109 112-GlyMetPheAlaLeuPheGlyArg-119 Antigenic Index - Jameson-WoIf 1-MetGluArgSerGlyVal-δ 14-ArgIleLeuArgMetProSerGluHis-22 28-ProLysProCysLysSerPheLysLeu-36 43-ValArgSerCysProCys-48 121-LeuSerLeuArgGlyGluAsnSerArgLeuArgAlaGluValLysLysSerAlaArgLeuSerGlyGlnLys LeuThrAla-147 152-AsnAlaAlaGluSerAlaLysGlnPro-160 Hydrophilic Regions - Hopp-Woods l-MetGluArgSerGlyVal-6 14-ArgIleLeuArgMetProSerGluHis-22 29-LysProCysLysSerPheLys-35 121-LeuSerLeuArgGlyGluAsnSerArgLeuArgAlaGluValLysLysSerAlaArgLeuSerGly-142 152-AsnAlaAlaGluSerAlaLysGlnPro-160 g578 AMPHI Regions - AMPHI lO-PheAlaAspPhePheLysAspPheAlaProGlnPheGlyGlyPheGlnAsn-26 34-AspPhePheAlaAlaPheLeuGlyGlyLeuGluGlyHisValGlyAsp-49 58-PheHisGlyValValAlaPhe-64 71-AsnThrAspAlaAlaArgPhe-77 Antigenic Index - Jameson-Wolf 13-PhePheLysAspPheAlaProGlnPheGlyGly-23 43-LeuGluGlyHisValGlyAspAlaAla-51 71-AsnThrAspAlaAlaArgPheAla-78 88-HisAsnGlnAsnIleGlnThrGlyAsnAspPheArgLeuGluArgGlyGlyValGly-106 Hydrophilic Regions - Hopp-Woods 73-AspAlaAlaArgPheAla-78 96-AsnAspPheArgLeuGluArgGlyGlyVal-105 g579 AMPHI Regions - AMPHI 6-PheAspPheLeuHisLeuIleSerValSerGlyTrpGlyHisLeuAlaGlu-22 49-ValAlaValMetArg-53 66-IleSerPheLeuCysAsn-71 115-LeuSerAsnPheAla-119 129-ProPheLysValGlyAspPheIleArgValGlyGlyPheGluGlyTyrValArgGluIleLys-149 206-LeuLysAlaAlaAlaGlu-211 258-GlnValValGluAsnLeuArg-264 Antigenic Index - Jameson-Wolf 110-SerLeuLysAspGlnLeuSer-116 128-ArgProPheLysVal-132 136-IleArgValGlyGlyPheGluGlyTyrValArgGluIleLysMet-150 154-SerLeuArgThrThrAspAsnGluGluValValLeu-165 175-IleValAsnArgSerSerLeuProLeu-183 198-LeuLysValAlaLysGluAlaValLeu-206 216-ValGlnAsnGluGluArgGlnPro-223 231-GlyAspAsnAlaIle-235 244-AsnGluAlaAspArgTrpThrLeu-251 253-CysAspLeuAsnGluGlnValValGluAsnLeuArgLysValAsn-267 271-ProPheProGlnArgAspIleHis-278 Hydrophilic Regions - Hopp-Woods 110-SerLeuLysAspGlnLeu-115 144-TyrValArgGluIleLysMet-150 155-LeuArgThrThrAspAsnGluGluValVal-164 198-LeuLysValAlaLysGluAlaValLeu-206 216-ValGlnAsnGluGluArgGlnPro-223 244-AsnGluAlaAspArgTrp-249 254-AspLeuAsnGluGlnValValGluAsnLeuArgLysValAsn-267 273-ProGlnArgAspIleHis-278 g580 AMPHI Regions - AMPHI 47-ProValSerAlaSerLys-52 54-SerLeuValLysProLeuSerGlnProLeuAla-64 Antigenic Index - Jameson-Wolf l-MetAspSerProLysValGlyCysGly-9 48-ValSerAlaSerLys-52 66-AlaArgProGluAlaAlaHis-72 81-ArgProAspAlaLeuAlaAspAsnSerValSerProThrHisAlaThrSerGlyGluVal-100 Hydrophilic Regions - Hopp-Woods 1-MetAspSerProLysVal-6 66-AlaArgProGluAlaAlaHis-72 81-ArgProAspAlaLeuAla-86 96-ThrSerGlyGluVal-100 g581 AMPHI Regions - AMPHI 43-SerHisPheIleSerLeu-48 56-ArgGluCysPheValGlyPhe-62 76-AlaThrAlaPheGlyArgIleAsnGln-84 90-GlnIleHisGlyPheLeuThrThrPheAlaGlyArgValAlaAsnProThrHisCysGlnSerGlnThr-112 Antigenic Index - Jameson-Wolf 8-GlyGlnThrGlyIleGluGlnAsnThrPheCysArgArgGlyPheThrArgIleAspMetGlyGlyAsnThrAs pVal-33 35-ValGlnAlaAspArgGlyLeuThrSer-43 49-SerLysLeuGluThrGluValArgGluCysPhe-59 79-PheGlyArgIleAsnGln-84 98-PheAlaGlyArgValAlaAsnProThrHisCysGlnSerGlnThrAla-113 Hydrophilic Regions - Hopp-Woods 35-ValGlnAlaAspArgGlyLeu-41 49-SerLysLeuGluThrGluValArgGlu-57 g582 AMPHI Regions - AMPHI 27-ThrAspAsnValThrArgLeuAla-34 65-ValArgSerSerLeu-69 91-GlyGluThrAlaAspIleTyrThrProLeuSer-101 139-SerSerProThrArg-143 169-IleAlaGluAsnLeuPhe-174 246-SerArgSerTrpAsnArgIleTyrAlaMet-255 263-LeuThrValIleProArgValTrpValArgAlaPheAspGlnSer-277 286-IleAlaAspTyrMetGlyTyr-292 334-LeuLysGlyValValArgGlyPheHisGlyTyrGlyGlu-346 Antigenic Index - Jameson-Wolf 26-LeuThrAspAsnValThr-31 34-AlaCysTyrAspArg-38 44-LeuProSerSerAlaGlyGlnGluGlyGlnGluSerLysAla-57 63-GluThrValArgSerSerLeuAspLysGlyGluAla-74 77-ValValGluLysGlyGlyAspAlaLeuProAlaAspSerAlaGlyGluThrAlaAsp-95 105-AspLeuAspLysAsnAspLeuArgGly-113 115-LeuGlyValArgGluHisAsnProMetTyr-124 130-TyrAsnAsnSerProAsnTyrAlaProSerSerProThrArgGlyThrThrValGlnGluLysPheGlyGln GlnLysArgAlaGluThrLysLeu-161 165-PheLysSerLysIleAla-170 173-LeuPheLysThrArgAla-178 183-GlyTyrThrGlnArgSerAspTrpGlnIleTyrAsnGlnGlyArgLysSerAlaProPheArgAsnThrAsp TyrLysPro-209 216-ProValLysAlaAspLeuProPheGlyGlyArgLeuArgMet-229 237-GlnSerAsnGlyGlnSerArgProGluSerArgSerTrpAsn-250 273-AlaPheAspGlnSerGlyAspLysAsnAspAsnProAspIleAlaAsp-288 291-GlyTyrGlyAspValLysLeuGlnTyrArgLeuAsnAspArgGlnAsnVal-307 312-ArgTyrAsnProLysThrGlyTyr-319 330-IleLysGlyLysLeuLysGlyValVal-338 342-HisGlyTyrGlyGluSerLeuIleAspTyrAsnHisLysGlnAsnGly-357 365-AsnAspTrpAspGlyIle-370 Hydrophilic Regions - Hopp-Woods 48-AlaGlyGlnGluGlyGlnGluSerLysAla-57 63-GluThrValArgSerSerLeuAspLysGlyGluAla-74 79-GluLysGlyGlyAspAlaLeuPro-86 88-AspSerAlaGlyGluThrAlaAsp-95 105-AspLeuAspLysAsnAspLeuArgGly-113 115-LeuGlyValArgGluHisAsn-121 140-SerProThrArgGlyThrThrValGlnGluLysPheGlyGlnGlnLysArgAlaGluThrLysLeu-161 165-PheLysSerLysIleAla-170 173-LeuPheLysThrArgAla-178 195-GlnGlyArgLysSerAlaProPheArgAsnThrAspTyrLysPro-209 225-GlyArgLeuArgMet-229 239-AsnGlyGlnSerArgProGluSerArgSerTrp-249 274-PheAspGlnSerGlyAspLysAsnAspAsnProAspIleAlaAsp-288 293-GlyAspValLysLeu-297 299-TyrArgLeuAsnAspArgGlnAsn-306 332-GlyLysLeuLysGlyValVal-338 352-AsnHisLysGlnAsn-356 g583 AMPHI Regions - AMPHI ll-HisLeuAlaPheCysAlaPheCysGlyIle-20 28-ArgLeuHisAsnArgMetTyrAsnAlaAlaAlaAlaArg-40 58-ValThrAspAlaGln-62 66-SerLysAsnGlyAspLysGlnIle-73 75-AspThrHisProGlnPro-80 117-GlyTyrAlaGlyTyrCysAspGln-124 141-AsnGlyGlyAsnHisThrAsp-147 162-GlyTyrGlyGlnCysGlnAsnGlnGlyAla-171 Antigenic Index - Jameson-Wolf 24-ThrAlaGlyAsnArgLeuHisAsnArgMetTyr-34 41-GlyIleGlyArgGlyAsnGlySerGlnGlnGlnPheGlyLysSerGluThrValThrAspAlaGlnArgPheS erSerLysAsnGlyAspLysGlnlleSerAspThrHisProGlnProCysPheGluGlnThrAlaArgAsnHisAs nCysAspGlyAsnGlnProAsnGlnArgIleGlyGluArgThrGlnArgIleAlaHisArgArgAlaArgPhe-11 4 117-GlyTyrAlaGlyTyrCysAspGlnProAspGlyAsnAsnArgGlnArgAlaGlnArgHisAsnLeuAlaAsp AsnGlyGlyAsnHisThrAspLysHisSerGlnGlnArgProSerLeuArgLeuAspProValGlyTyrGlyGlnC ysGlnAsnGlnGlyAlaGlnTyrCysGlyAsnGlyGluGlyTyrArgPhe-182 190-AspLeuArgLysLysAspArgProGluLysSerGluLys-202 Hydrophilic Regions - Hopp-Woods 27-AsnArgLeuHisAsn-31 41-GlyIleGlyArgGlyAsnGlySer-48 51-GlnPheGlyLysSerGluThrValThrAspAlaGlnArgPheSerSerLysAsnGlyAspLysGlnIleSerA spThrHisPro-78 84-GlnThrAlaArgAsnHisAsnCysAspGlyAsnGlnProAsnGlnArgIleGlyGluArgThrGlnArgIleA laHisArgArgAlaArgPhe-114 123-AspGlnProAspGlyAsnAsnArgGlnArgAlaGlnArgHisAsnLeuAlaAspAsnGlyGlyAsnHisThr AspLysHisSerGlnGlnArgProSerLeuArgLeuAspPro-160 178-GluGlyTyrArgPhe-182 190-AspLeuArgLysLysAspArgProGluLysSerGluLys-202 g584 AMPHI Regions - AMPHI 28-GluPheSerGluSerAlaGly-34 60-AlaGluPheValLysLysPheAsnAsnPheThrArgLys-72 116-PheAspAlaLeuAsnArgPheIleAlaAspVal-126 148-IleAspGlnValSerLysAsp-154 166-LeuAlaGlyValLeuGly-171 Antigenic Index - Jameson-Wolf 3 -ValAlaGlnAspThrMetSer-43 50-AlaGluGlyArgAspLysAsnAlaVal-58 61-GluPheValLysLysPheAsnAsnPheThrArgLysSerLysAsnGlySerPheLysThrGluLeuValSerA rgSerAlaMetProArgTyrGlnTyrThrAsnGlyArgArglleGlnThrGlyTrpGluGluArgAlaGluPheLy sAlaGluGlyArgAspPheAspAla-118 126-ValGlnThrAspAlaSerLeuGluAspThrAspPheSerValSerArgGluArgArgAsnGluValIleAsp GlnValSerLysAspAlaValLeu-157 159-PheLysAlaArgAlaGluLysLeuAla-167 189-IleAlaGlyAspGlyAlaValArgAlaLysMetLeuArg-201 210-AsnMetLysGlyThrAspSerAlaAlaProGlyValGluGluIleSer-225 Hydrophilic Regions - Hopp-Woods 50-AlaGluGlyArgAspLysAsnAlaVal-58 67-AsnAsnPheThrArgLysSerLysAsnGlySerPheLysThrGluLeuValSer-84 95-AsnGlyArgArgIleGlnThrGlyTrpGluGluArgAlaGluPheLysAlaGluGlyArgAspPheAspAla- 118 130-AlaSerLeuGluAspThrAspPheSerValSerArgGluArgArgAsnGluValIleAspGlnValSerLys AspAlaValLeu-157 159-PheLysAlaArgAlaGluLysLeuAla-167 193-GlyAlaValArgAlaLysMetLeuArg-201 210-AsnMetLysGlyThrAspSerAlaAlaProGlyValGluGluIleSer-225 g585 AMPHI Regions - AMPHI 6-ArgIlePheAlaThrPheCysAlaValIleValCys-17 46-ThrThrLeuMetGlySerIleIleSer-54 65-ArgGluIleLeuThrGluTrpLys-72 93-AsnArgTyrIleAsp-97 136-AspAsnHisGlnAlaGlnArg-142 153-ProLeuAlaProIleTrp-158 178-LeuAlaGlyAsnIleAlaLysProIleArgIleLeuGlyAsnGlyMetAspArgValAlaGluArgGlu-20 0 Antigenic Index - Jameson-WoIf 36-AsnGlnPheAsnGlnArgArgThrIleGlu-45 56-PheLysThrArgGlyAspAsnGlyAlaArgGluIleLeuThrGluTrpLysAsnSerProValSer-77 84-GlnGlyAspGluLysLysAspIleLeu-92 99-TyrThrIleGluArgAlaArgLeu-106 119-IleGluTyrAspArgPheGlyGlu-126 134-GlyTrpAspAsnHisGlnAlaGlnArgLeuProSerPro-146 189-LeuGlyAsnGlyMetAspArgValAlaGluArgGluLeuGluAspArgValCysGlnGlnValArgAspArg AspAspGluLeuAlaAsp-218 225-ThrMetValGluLysLeuGlu-231 Hydrophilic Regions - Hopp-Woods 37-GlnPheAsnGlnArgArgThrIleGlu-45 56-PheLysThrArgGlyAspAsnGlyAlaArgGluIleLeuThr-69 84-GlnGlyAspGluLysLysAspIleLeu-92 100-ThrIleGluArgAlaArgLeu-106 119-IleGluTyrAspArgPheGlyGlu-126 139-GlnAlaGlnArgLeu-143 192-GlyMetAspArgValAlaGluArgGluLeuGluAspArgValCysGlnGlnValArgAspArgAspAspGlu LeuAlaAsp-218 225-ThrMetValGluLysLeuGlu-231 g586 AMPHI Regions - AMPHI 12-AspAsnPheLysTyrPheTrpLysThr-20 30-IleLeuAlaAlaLeuGly-35 56-ValLeuAlaAsnIleValGluLysAlaGlnAsnLysAlaPro-69 80-LeuGlnGlnSerTyrProHisSerIleSer-89 177-SerGlnGluAlaLeuLysAsnTyrGlyGlnAlaLeuGluLysMetProGlnAspSerValGlyArg-198 Antigenic Index - Jameson-Wolf 4-HisLeuGluGluGlnGlnGluLeuAspAsn-13 43-GlnAsnArgAlaAlaSerGlnAsnGlnGluAla-53 60-IleValGluLysAlaGlnAsnLysAlaProGlnSerGluIleAsnAlaGluLeuSerLysLeuGlnGln-82 100-ThrGluPheAspAlaGlnArgTyrAspValAlaGluGly-112 118-LeuSerAsnGlnLysAspSerLeu-125 140-GlnGlnLysLysTyrAspAla-146 153-ThrProValGluAlaAspPhe-159 164-MetGluThrLysGlyAspVal-170 172-AlaAlaGlnGluLysSerGlnGluAlaLeuLysAsnTyrGlyGlnAlaLeuGluLysMetProGlnAspSer ValGlyArgGluLeuLeu-201 204-LysLeuAspSerLeuLys-209 Hydrophilic Regions - Hopp-Woods 4-HisLeuGluGluGlnGlnGluLeuAspAsn-13 45-ArgAlaAlaSerGlnAsnGlnGluAla-53 60-IleValGluLysAlaGlnAsnLysAlaProGlnSerGluIleAsnAlaGluLeuSerLysLeu-80 100-ThrGluPheAspAlaGlnArgTyrAspValAlaGluGly-112 120-AsnGlnLysAspSerLeu-125 140-GlnGlnLysLysTyrAspAla-146 153-ThrProValGluAlaAspPhe-159 164-MetGluThrLysGlyAspVal-170 172-AlaAlaGlnGluLysSerGlnGluAlaLeuLys-182 187-AlaLeuGluLysMetProGlnAspSerValGlyArgGluLeuLeu-201 204-LysLeuAspSerLeuLys-209 g587 AMPHI Regions - AMPHI 6-LeuProAlaLeuProAlaIleLeuProLeuSerAla-17 122-LysArgMetSerAspIleSerAlaGlyIleSerHis-133 Antigenic Index - Jameson-Wolf 27-AspIleMetThrAspLysGlyLysTrpLysLeuGluThr-39 45-AsnSerGluAsnSerArgAla-51 71-ThrGluIleGlnGluAsnGlySerAsnThr-80 95-GlyAsnThrAspIleTyrGlySerGlySer-104 108-HisGluGluArgLysLeuAspGlyAsnGlyLysThrArgAsnLysArgMetSerAspIle-127 135-PheLeuLysAspGlyLysAsnProAla-143 151-ThrValTyrGluLysSerArgAsnLysAlaSerLeuIleLysLysArgGlyLeuCys-169 Hydrophilic Regions - Hopp-Woods 27-AspIleMetThrAspLysGlyLysTrpLysLeu-37 47-GluAsnSerArgAla-51 72-GluIleGlnGluAsnGlySerAsn-79 108-HisGluGluArgLysLeuAspGlyAsnGlyLysThrArgAsnLysArgMetSerAspIle-127 135-PheLeuLysAspGlyLysAsn-141 151-ThrValTyrGluLysSerArgAsnLysAlaSerLeuIleLysLysArgGlyLeu-168 g588 AMPHI Regions - AMPHI 55-ArgGlyTyrThrGlySer-60 Antigenic Index - Jameson-Wolf 24-SerProTyrGlnGluThrGlyCysThrTyrGluGlyGlyIleGlyLysAspGlyLeuProSerGlyLysGlyI leTrpArgCysArgAspGlyArgGlyTyrThrGlySerPheLysAsnGlyLysPheAspGlyGlnGly-70 85-PheAsnSerAspSerThrLysPheArgAsn-94 105-LeuAlaHisGlyArgPheAlaAlaSerGlnAsnGlyGluThr-118 124-MetArgThrArgHisAsp-129 Hydrophilic Regions - Hopp-Woods 36-GlyIleGlyLysAspGlyLeuProSer-44 49-TrpArgCysArgAspGlyArgGlyTyr-57 61-PheLysAsnGlyLysPheAspGly-68 85-PheAsnSerAspSerThrLysPheArgAsn-94 124-MetArgThrArgHisAsp-129 g589 AMPHI Regions - AMPHI 18-AlaSerArgIleGluLysValLeu-25 54-ValAlaAspIleAlaLysIleIleGluLys-63 103-MetValGlyMetMet-107 127-ValLeuAlaSerIleValGlnLeuTrpLeuAla-137 155-MetAspValLeuValThrIle-161 198-PheValSerLeuGlyLysPheLeuGluHisArg-208 23 O-ValGlnArgAsnGlyGlu-235 245-GlnIleGlyAspLeuIleArg-251 315-LeuGlyAspMetMetAsnAlaLeuSerGluAlaGln-326 330-AlaProIleAlaArgValAlaAspLys-338 396-MetGlyLysAlaVal-400 471-IleValSerAlaAlaGln-476 482-IleProAlaAlaGln-486 502-GlyValGlyLeuValLys-507 539-LysProIleGlyAlaPheAlaLeuSerAspAlaLeuLys-551 553-AspThrAlaGluAlaIleGlyArgLeu-561 591-AlaPheGlyAsnMetSerProCysAspLysAlaAlaGluValGlnLysLeuLysAlaAla-610 617-ValGlyAspGlyIleAsnAspAlaPro-625 640-AlaAspValAlaGluHisThr-646 653-GlnHisSerValAsnGlnLeu-659 680-AlaPhePheTyrAsnIleLeu-686 Antigenic Index - Jameson-Wolf l-MetGlnGlnLysIleArgPhe-7 17-CysAlaSerArgIleGluLysValLeuAsnLysLysAspPheValGluSer-33 39-AlaSerGluGluAlaGlnValThrPheAspGlySerLysThrSerVal-54 59-LysIleIleGluLysThrGlyTyrGlyAlaLysGluLysThrGluAspThrLeuProGlnProGluAlaGluH is-83 114-ThrArgHisAspTrp-118 148-IleLysGlyGlyLeu-152 205-LeuGluHisArgThrLysLysSerSerLeuAsn-215 228-ValAsnValGlnArgAsnGlyGluTrpLysGlnLeuProIleAspGln-243 248-AspLeuIleArgThrAsnHisGlyGluArgIleAlaAla-260 262-GlyIleIleGluSerGlySerGlyTrpAlaAspGluSerHisLeuThrGlyGluSerAsnProGluGluLys LysAlaGlyGly-289 298-ThrGluGlySerVal-302 323-SerGluAlaGlnGlySerLysAlaProIle-332 334-ArgValAlaAspLysAlaAla-340 361-IleLysGlyAspTrp-365 396-MetGlyLysAlaValLys-401 409-AlaAlaAlaMetGluGluAlaAlaHis-417 422-ValLeuAspLysThrGlyThrLeuThrGluGlyArgProGlnVal-436 443-ProAspSerGlyPheAspGluAspAlaLeu-452 459-ValGluGlnAsnAla-463 498-AlaGluValGluGly-502 507-LysSerGlyLysAlaGluPheAla-514 520-LysPheSerAspGlyVal-525 535-SerValAsnGlyLysProIle-541 548-AspAlaLeuLysAlaAspThrAlaGluAlaIleGlyArgLeuLysLysHisAsnIle-566 572-SerGlyAspAsnGlnSerThrVal-579 596-SerProCysAspLysAlaAlaGluValGlnLysLeuLysAlaAlaGly-611 617-ValGlyAspGlyIleAsnAspAla-624 636-MetLysGlyGlyAlaAspValAlaGlu-644 Hydrophilic Regions - Hopp-Woods l-MetGlnGlnLysIleArgPhe-7 19-SerArgIleGluLysValLeuAsnLysLysAspPheValGlu-32 39-AlaSerGluGluAlaGlnVal-45 48-AspGlySerLysThrSerVal-54 64-ThrGlyTyrGlyAlaLysGluLysThrGluAspThrLeuProGlnProGluAlaGluHis-83 205-LeuGluHisArgThrLysLysSerSerLeu-214 229-AsnValGlnArgAsnGlyGluTrpLys-237 253-AsnHisGlyGluArgIleAlaAla-260 262-GlyIleIleGluSer-266 270-TrpAlaAspGluSerHisLeuThrGlyGluSerAsnProGluGluLysLysAlaGlyGly-289 323-SerGluAlaGlnGlySerLysAlaProIle-332 334-ArgValAlaAspLysAlaAla-340 409-AlaAlaAlaMetGluGluAlaAlaHis-417 422-ValLeuAspLysThrGlyThrLeuThrGluGlyArgProGln-435 445-SerGlyPheAspGluAspAlaLeu-452 459-ValGluGlnAsnAla-463 498-AlaGluValGluGly-502 507-LysSerGlyLysAlaGluPheAla-514 548-AspAlaLeuLysAlaAspThrAlaGluAlaIleGlyArgLeuLysLysHisAsnIle-566 573-GlyAspAsnGlnSer-577 596-SerProCysAspLysAlaAlaGluValGlnLysLeuLysAlaAlaGly-611 638-GlyGlyAlaAspValAlaGlu-644 g590 AMPHI Regions - AMPHI 90-ValThrLeuValAsnHisIleThrHis-98 100-ProPheAlaGlyGlyPhe-105 123-LysValLeuGluArgPhePhe-129 132-GlnValProValSerLeu-137 177-TyrGlnLysGlyPheLysSerTyrArgAsnSer-187 213-GluThrSerAspGlyIleAsnProLeu-221 248-AsnGluLeuValAsnLeuVal-254 331-LysArgLysPheAla-335 420-LysMetLeuGluAsp-424 450-AsplleAsnGluThrLeuArgLeuMet-458 460-AspSerThrValGln-464 Antigenic Index - Jameson-Wolf l-MetLysLysProLeu-5 26-LysAlaGluGluSerLeuThrGlnGlnGlnLysIleLeuGlnLysThrGly-42 48-SerHisGlnTyrAspArgGlyTrpPheThrSerThrGluThrThrValIleArgLeuLysProGluLeu-70 75-GlnLysTyrLeuProAspAsnLeuLys-83 lll-IleGluThrGluPheLysTyrAlaProGluThrGluLysValLeuGlu-126 128-PhePheGlyLysGlnVal-133 144-AsnGlySerGlyLysMetGluVal-151 157-AspTyrGluGluLeuSerGly-163 179-LysGlyPheLysSerTyrArgAsnSerTyrAspAlaProLeu-192 196-LysLeuAlaAspLysGlyAspAlaAlaPheGlu-206 208-AlaHisPheAspSerGluThrSerAspGlyIleAsn-219 233-PheSerLeuGluTrpLysGluGlyValAspTyr-243 264-AsnProAsnGlySerIleAlaProSerLysIleGluValGly-277 281-PheSerThrLysThrGlyGluSerGlyAla-290 292-IleAspSerGluGlyArgPheArgPhe-300 304-ValTyrGlyAspGluLysTyrGlyPro-312 329-ValLeuLysArgLysPheAla-335 338-SerAlaLysLysMetThrGluGluGlnIleArgAsnAspLeu-351 355-ValLysGlyAspAlaSerGly-361 378-LeuProGlnGlyLysIleAspValGlyGly-387 393-GlyMetLysLysGluAspLeuAsnGln-401 406-LeuLysLysThrGluAlaAsnIle-413 437-AsnAlaGluAspGluAlaGluAlaArgAlaSerIle-448 450-AspIleAsnGluThrLeu-455 466-MetAlaArgGluLysTyrLeu-472 485-LeuLysAsnAsnAlaLeuLysLeuAsnGlyLysThrLeuGlnAsnGluProAspProAspPheAspGluGly AspMetValSerGlyGlnProHis-516 Hydrophilic Regions - Hopp-Woods 1-MetLysLysProLeu-5 26-LysAlaGluGluSerLeuThrGln-33 62-ThrValIleArgLeuLysProGluLeu-70 77-TyrLeuProAspAsnLeu-82 lll-IleGluThrGluPheLysTyrAlaProGluThrGluLysValLeuGlu-126 147-GlyLysMetGluVal-151 157-AspTyrGluGluLeuSerGly-163 180-GlyPheLysSerTyrArgAsnSerTyr-188 196-LysLeuAlaAspLysGlyAspAlaAlaPheGlu-206 208-AlaHisPheAspSerGluThrSerAspGly-217 233-PheSerLeuGluTrpLysGluGlyValAspTyr-243 272-SerLysIleGluValGly-277 292-IleAspSerGluGlyArgPheArgPhe-300 304-ValTyrGlyAspGluLysTyrGlyPro-312 329-ValLeuLysArgLysPheAla-335 338-SerAlaLysLysMetThrGluGluGlnIleArgAsnAspLeu-351 355-ValLysGlyAspAla-359 381-GlyLysIleAspValGlyGly-387 393-GlyMetLysLysGluAspLeuAsn-400 406-LeuLysLysThrGluAlaAsnIle-413 437-AsnAlaGluAspGluAlaGluAlaArgAlaSerIle-448 450-AspIleAsnGluThrLeu-455 466-MetAlaArgGluLysTyrLeu-472 496-ThrLeuGlnAsnGluProAspProAspPheAspGluGlyAspMetValSer-512 g591 AMPHI Regions - AMPHI 6-AlaPheIlePheAla-10 17-LeuHisGluPheGlyHisTyrIleValAla-26 61-LeuGlyGlyTyrValLysMetValAsp-69 143-GlyAspLysIleGlnSerValAsnGlyValSerValGln-155 181-SerGlyAlaGlnThrValArgThrIleAspAlaAlaGlyThrProGluAlaGlyLysIleAlaLys-202 218-AlaGlyGlyValGluLys-223 234-ProGlyAspArgLeu-238 245-ProIleAlaSerTrpGlnGluTrpAlaAsnLeuThrArg-257 304-AlaTrpAspAlaGlnIleArg-310 313-TyrArgProSerValValArgAlaPheGly-322 324-GlyTrpGluLysThrValSerHis-331 335-ThrLeuLysPhePheGlyLysLeuIle-343 351-HisIleSerGlyProLeuThrIleAla-359 373-TyrLeuGluPheLeuAlaLeu-379 Antigenic Index - Jameson-Wolf 44-PhePheThrArgLysArgGlyAspThrGlu-53 68-ValAspThrArgGluGlyGluValSerGluAlaAspLeu-80 84-PheAspLysGlnHisProAlaLysArg-92 128-ThrValGluProAspThrValAla-135 139-GlyPheGlnSerGlyAspLysIleGlnSer-148 156-AspTrpSerSerAlaGlnThr-162 187-ArgThrIleAspAlaAlaGlyThrProGluAlaGlyLysIleAlaLysAsnGlnGly-205 219-GlyGlyValGluLysGlySerProAlaGluLysAlaGlyLeuLysProGlyAspArgLeuThrAlaAlaAsp GlyLysProIle-246 254-AsnLeuThrArgGlnSerProGlyLysLysIle-264 268-TyrGluArgAlaGlyGlnThrHisThrAlaAspIleArgProAspThrValGluGlnProAspHisThrLeu -291 295-ValGlyLeuArgProGlnProAspArgAlaTrp-305 307-AlaGlnIleArgArgSerTyrArgProSerVal-317 327-LysThrValSerHisSer-332 343-IleSerGlyAsnAla-347 362-AlaGlyGlnSerAla-366 408-IleArgGlyLysProLeuGlyGluArgValGln-418 Hydrophilic Regions - Hopp-Woods 44-PhePheThrArgLysArgGlyAspThr-52 68-ValAspThrArgGluGlyGluValSerGluAlaAspLeu-80 84-PheAspLysGlnHisProAlaLysArg-92 129-ValGluProAspThrValAla-135 139-GlyPheGlnSerGlyAspLysIleGlnSer-148 193-GlyThrProGluAlaGlyLysIleAlaLys-202 220-GlyValGluLysGlySerProAlaGluLysAlaGlyLeuLysProGlyAspArgLeuThrAlaAlaAspGly LysPro-245 256-ThrArgGlnSerProGlyLysLysIle-264 268-TyrGluArgAlaGlyGln-273 277-AlaAspIleArgProAspThrValGluGlnProAsp-288 299-ProGlnProAspArgAlaTrp-305 308-GlnIleArgArgSerTyrArg-314 362-AlaGlyGlnSerAla-366 411-LysProLeuGlyGluArgValGln-418 g592 AMPHI Regions - AMPHI 6-PheGlyGlnIlePheSer-ll 21-GlyGlyLeuLeuGlyGlyLeuIle-28 50-AlaProAsnAlaAlaAlaAlaAla-57 65-GlnGlyMetIleGlnMetLeuGlyValPheValAsp-76 94-ProTyrGlyAspLeu-98 109-ValSerGlnValGlyGlnTrp-115 153-ThrAlaValPheArgMet-158 165-TyrPheGlyAlaValAla-170 185-IleMetAlaTrpIleAsnLeuValAlaIleLeuLeuLeuSer-198 Antigenic Index - Jameson-Wolf 35-GlyIleLysArgGlyLeuTyrSerAsnGluAlaGlyMetGlySerAlaProAsnAla-53 57-AlaGluValLysHisProValSer-64 93-GlnProTyrGlyAspLeuSerGly-100 137-AlaTyrAlaGluSerAsnVal-143 206-ArgAspTyrThrAlaLysLeuLysMetGlyLysAspProGluPheLysLeuSerGluHisProGlyLeuLys ArgArgIleLysSerAspValTrp-237 Hydrophilic Regions - Hopp-Woods 35-GlyIleLysArgGlyLeuTyr-41 57-AlaGluValLysHisProVal-63 212-LeuLysMetGlyLysAspProGluPheLysLeuSerGlu-224 226-ProGlyLeuLysArgArgIleLysSer-234 g593 AMPHI Regions - AMPHI 6-GlyLeuCysLysCysPheGlyGly-13 41-SerThrLeuLeuAsnMetIleAlaGlyIleValArg-52 87-HisMetSerAlaLeuGlu-92 113-LeuSerAlaLeuAlaGlu-118 125-AlaHisArgLysProGluLysLeuSerGlyGlyGlu-136 159-PheSerSerLeuAsp-163 165-HisLeuArgAspArgLeuArgArgMet-173 217-GluThrLeuIleGlnThrProAlaGlyValGlnValAlaArgLeuMetGlyLeu-234 259-LeuLeuSerLeuValArgLeuProAspSerLeuArg-270 290-HisThrAspGlyIle-294 Antigenic Index - Jameson-Wolf 10-CysPheGlyGlyLysThrValAla-17 24-ValGlyArgGlyLysIle-29 33-LeuGlyArgSerGlyCysGlyLysSerThr-42 50-IleValArgProAspGlyGlyGluIleArgLeuAsnGlyGluAsnIleThr-66 69-ProProGluLysArgArgIle-75 99-LysMetGlnLysMetProLysAlaGluAlaGluArgLeuAla-112 119-ValGlyLeuGluAsnGluAlaHisArgLysProGluLysLeuSerGlyGlyGluLysGlnArgLeuAlaLeu -142 157-GluSerPheSerSerLeu-162 164-ThrHisLeuArgAspArgLeuArgArgMetThrAlaGluArgIleArgLysGlyGlyIle-183 190-HisSerProGluGluAlaCysThrAlaAlaAspGluIleAlaVal-204 206-HisGluGlyLysIleLeuGlnCysGlyThrProGluThrLeu-219 233 -GlyLeuProAsnThrAspAspAspArgHis11eProGlnAsnAla-247 250-LeuAspAsnHisGlyThrGluCysArg-258 264-ArgLeuProAspSerLeuArgLeu-271 275-HisProGluHisGlyGlu-280 289-GlnHisThrAspGlyIleSerGlyAsnGly-298 300-ValArgIleArgValAspGluGlyArgIleValArgPheArg-313 Hydrophilic Regions - Hopp-Woods 25-GlyArgGlyLysIle-29 36-SerGlyCysGlyLys-40 51-ValArgProAspGlyGlyGluIleArgLeuAsnGly-62 69-ProProGluLysArgArgIle-75 99-LysMetGlnLysMetProLysAlaGluAlaGluArgLeuAla-112 119-ValGlyLeuGluAsnGluAlaHisArgLysProGluLysLeuSerGlyGlyGluLysGlnArgLeuAlaLeu -142 164-ThrHisLeuArgAspArgLeuArgArgMetThrAlaGluArgIleArgLysGlyGly-182 191-SerProGluGluAlaCysThrAlaAlaAspGluIleAlaVal-204 206-HisGluGlyLysIle-210 236-AsnThrAspAspAspArgHisIlePro-244 253 -HisGlyThrGluCysArg-258 264-ArgLeuProAspSerLeuArg-270 275-HisProGluHisGlyGlu-280 289-GlnHisThrAspGlyIleSer-295 300-ValArgIleArgValAspGluGlyArgIleValArgPheArg-313 g594 AMPHI Regions - AMPHI 21-SerIleLeuArgLeu-25 108-AlaGlyArgLysCysGlnGluThrAlaAlaAla-118 138-AlaIleLysHisCysAsnPheThr-145 Antigenic Index - Jameson-Wolf l-MetGlyAlaAspThrAspGlyAspLysAspValArgLeuAsnArgThr-16 51-ValGluHisProAsnArgPhe-57 75-HisLeuAspGlySerThrGlyGly-82 86-PheArgArgGluLysThrGlyHisLysArgArgCysHisThrGlnCys-101 103-HisSerAlaArgAlaAlaGlyArgLysCysGlnGluThr-115 137-ArgAlaIleLysHisCysAsn-143 Hydrophilic Regions - Hopp-Woods l-MetGlyAlaAspThrAspGlyAspLysAspValArgLeuAsnArg-15 86-PheArgArgGluLysThrGlyHiSLysArgArgCysHis-98 105-AlaArgAlaAlaGlyArgLysCysGlnGluThr-115 g595 AMPHI Regions - AMPHI 20-CysGlnProProGluAla-25 98-GlyLeuSerAspLysMetAsnArg-105 140-AlaAspLeuGluLysLeuProGlnProLeuAlaAspTyrLys-153 157-GlnGlyGluValLys-161 170-PheThrGluAlaValLysAlaGlyAspIleGluLysAlaLys-183 196-IleGluProIleAlaGluLeuPheSerGluLeuAspProValIleAspAlaCysGluAspAspPheLysAsp Gly-220 224-AlaGlyPheThrGlyPheHisArg-231 247-GluThrAlaAlaLysLeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 274-ValGlyGlyAlaSerGluLeuIleGlu-282 311-SerLysLysIleValAspLeuPheArgProLeu-321 337-PheLysGlnValAsnGluIleLeuAlaLys-346 351-AspGlyPheGluThrTyrAspLysLeuSerGluAlaAsp-363 369-AlaProIleAsnAlaLeuAlaGluAspLeuAlaGlnLeuArgGlyIleLeuGlyLeu-387 Antigenic Index - Jameson-Wolf 1-MetArgLysPheAsn-5 21-GlnProProGluAlaGluLysAlaAlaPro-30 32-AlaSerGlyGluThrGlnSerAlaAsnGluGlyGlySer-44 50-AsnAspAsnAlaCysGluProMe AsnLeu-59 70-IleLysAsnAsnSerGlyArgLysLeuGluTrpGluIle-82 87-MetValValAspGluArgGluAsnIleAla-96 98-GlyLeuSerAspLysMetAsnArgAsnLeuLeuProGlyGluTyrGluMet-114 120-ThrAsnProArgGlyLysLeuValVal-128 130-AspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuPro-146 158-GlyGluValLysGluLeuAlaAlaLysThrLysThrPheThrGluAlaValLysAlaGlyAspIleGluLys AlaLysSer-184 191-ValHisTyrGluArgIleGluProIle-199 204-SerGluLeuAspProValIleAspAlaCysGluAspAspPheLysAspGlyAlaLysAspAlaGly-225 238-ValGluLysAspValSerGlyValLysGluThrAlaAla-250 252-LeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 269-ProProGlyLysValValGlyGlyAla-277 279-GluLeuIleGluGluAlaAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSer AspPheGlnAlaAsnAlaAspGlySerLysLysIleValAsp-316 322-IleGluAlaLysAsnLysAlaLeuLeuGluLysThrAspThrAsnPheLysGlnValAsn-341 345-AlaLysTyrArgThrLysAspGlyPheGluThrTyrAspLysLeuSerGluAlaAspArgLysAlaLeu-36 7 374-LeuAlaGluAspLeuAlaGln-380 Hydrophilic Regions - Hopp-Woods 1-MetArgLysPheAsn-5 21-GlnProProGluAlaGluLysAlaAlaPro-30 32-AlaSerGlyGluThrGlnSerAlaAsnGluGlyGlySer-44 72-AsnAsnSerGlyArgLysLeuGluTrpGluIle-82 87-MetValValAspGluArgGluAsnIle-95 99-LeuSerAspLysMetAsnArg-105 110-GlyGluTyrGluMet-114 122-ProArgGlyLysLeuValVal-128 131-SerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuPro-146 158-GlyGluValLysGluLeuAlaAlaLysThrLysThrPheThrGluAlaValLysAlaGlyAspIleGluLys AlaLysSer-184 191-ValHisTyrGluArgIleGluProIle-199 204-SerGluLeuAspProValIleAspAlaCysGluAspAspPheLysAspGlyAlaLysAspAlaGly-225 238-ValGluLysAspValSerGlyValLysGluThrAlaAla-250 252-LeuMetThrAspValGluAlaLeuGlnLysGluIleAsp-264 279-GluLeuIleGluGluAlaAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHis-298 308-AlaAspGlySerLysLysIleValAsp-316 322-IleGluAlaLysAsnLysAlaLeuLeuGluLysThrAspThrAsnPhe-337 347-TyrArgThrLysAspGlyPheGluThrTyrAspLysLeuSerGluAlaAspArgLysAlaLeu-367 374-LeuAlaGluAspLeuAlaGln-380 g596-2 AMPHI Regions - AMPHI 9-MetLeuArgValSerLysValVal-16 50-LeuArgIleMetAlaGlyValAspLys-58 87-ValArgGluGluValGluSerGlyLeuGlyGluValAlaAlaAlaGlnLysArgLeuGluGluValTyrAlaG luTyr-112 192-ProThrAsnHisLeuAsp-197 202-GluTrpLeuGluGlnPheLeuValArgPheProGly-213 296-ArgPheGluGluMetSerAsnTyr-303 322-LeuGlyAsnGluValIleGluPheValAsnValSerLysSerPhe-336 366-SerThrLeuPheLysMet-371 409-AspAsnIleAlaGlu-413 440-AspGlnSerLysIleAlaArgGlnLeuSerGly-450 483-LeuArgAlaLeuGluAspAlaLeuLeuGluPheAla-494 Antigenic Index - Jameson-Wolf 16-ValProProGlnLysThrIleIleLysAspIleSer-27 41-LeuAsnGlyThrGlyLysSerThrVal-49 54-AlaGlyValAspLysGluPheGluGlyGluAla-64 75-LeuProGlnGluProGluLeuAspProGluLysThrValArgGluGluValGluSerGlyLeu-95 99-AlaAlaAlaGlnLysArgLeuGluGluValTyr-109 112-TyrAlaAsnProAspAlaAspPheAspAlaLeuAlaGluGluGlnGlyArgLeuGlu-130 136-GlySerSerThrGlyGlyGlyAlaGluHisGluLeuGluIleAlaAlaAspAlaLeuArgLeuProAspTrp AspAlaLysIle-163 165-AsnLeuSerGlyGlyGluLysArgArgValAla-175 181-LeuSerLysProAspMet-186 190-AspGluProThrAsnHisLeuAspAlaGluSer-200 219-ThrHisAspArgTyrPhe-224 233-LeuGluLeuAspArgGlyHisGlyIle-241 243-TrpLysGlyAsnTyrSerSer-249 251-LeuGluGlnLysGluLysArgLeuGluAsnGluAlaLysSerGluAlaAlaArgValLysAlaMetLysGln GluLeuGluTrpValArgGlnAsnAlaLysGlyArgGlnAlaLysProLysAlaArgLeuAlaArgPheGluGluM etSerAsnTyrGluTyrGlnLysArgAsnGluThrGlnGlu-313 319-AlaGluArgLeuGlyAsnGluVal-326 333-SerLysSerPheGlyAspLysValLeu-341 360-ProAsnGlyAlaGlyLysSerThrLeu-368 373-AlaGlyLysGluGlnProAspSerGlyGluValLysIle-385 395-AspGlnSerArgGluGlyLeuGlnAsnAspLysThrValPhe-408 411-IleAlaGluGlyArgAspIleLeu-418 425-IleProAlaArgGlnTyrLeuGlyArgPheAsnPheLysGlySerAspGlnSerLysIleAlaArgGlnLeu SerGlyGlyGluArgGlyArgLeuHisLeu-458 471-LeuAspGluProSerAsnAspLeuAspValGluThrLeuArgAlaLeuGlu-487 501-SerHisAspArgTrpPhe-506 516-AlaCysGluGlyAspSerLysTrp-523 527-AspGlyAsnTyrGlnGluTyrGluAlaAspLysLysArgArgLeuGlyLysGluGlyAlaLysProLysArg IleLysTyrLysProValThrArg-558 Hydrophilic Regions - Hopp-Woods 54-AlaGlyValAspLysGluPheGluGlyGluAla-64 77-GlnGluProGluLeuAspProGluLysThrValArgGluGluValGluSerGlyLeu-95 99-AlaAlaAlaGlnLysArgLeuGluGluValTyr-109 113-AlaAsnProAspAlaAspPheAspAlaLeuAlaGluGluGlnGlyArgLeuGlu-130 141-GlyGlyAlaGluHisGluLeuGluIleAlaAlaAspAlaLeuArg-155 157-ProAspTrpAspAlaLysIle-163 167-SerGlyGlyGluLysArgArgValAla-175 181-LeuSerLysProAsp-185 190-AspGluProThrAsnHisLeuAspAlaGluSer-200 233-LeuGluLeuAspArgGlyHis-239 251-LeuGluGlnLysGluLysArgLeuGluAsnGluAlaLysSerGluAlaAlaArgValLysAlaMetLysGln GluLeuGluTrp-278 280-ArgGlnAsnAlaLysGlyArgGlnAlaLysProLysAlaArgLeuAlaArgPheGluGluMetSerAsn-30 2 304-GluTyrGlnLysArgAsnGluThrGln-312 319-AlaGluArgLeuGlyAsnGluVal-326 373-AlaGlyLysGluGlnProAspSerGlyGluValLysIle-385 395-AspGlnSerArgGluGlyLeuGlnAsnAspLysThrValPhe-408 411-IleAlaGluGlyArgAspIleLeu-418 435-AsnPheLysGlySerAspGlnSerLysIleAlaArg-446 448-LeuSerGlyGlyGluArgGlyArgLeuHisLeu-458 472-AspGluProSerAsnAspLeuAspValGluThrLeuArgAlaLeuGlu-487 517-CysGluGlyAspSer-521 529-AsnTyrGlnGluTyrGluAlaAspLysLysArgArgLeuGlyLysGluGlyAlaLysProLysArgIleLys Tyr-553 g597 AMPHI Regions - AMPHI 6-SerAsnSerLeuLysGlnLeuGlnGlu-14 45-TrpAspLysPheGlnLysLeu-51 68-GlnIleSerArgPheValSerGly-75 101-LeuArgTyrThrArgTyrValAsnAla-109 lll-AsnArgGluValValLysAspLeuGluLysGlnGln-122 132-11eAsnAsnGluLeuAlaArgLeuLysLys-141 144-AlaAsnValGlnSerLeu-149 157-AspAlaAlaGluGlnThrGlu-163 170-LysIleSerLysAspAlaArg-176 189-AsnLysLeuLeuSer-193 253-ProSerValMetGlyIleGlySerAlaAspGlyPheSerArgMetGlnGlyArgLeuLysLysProValAsp GlyValProThrGly-281 302-ProAlaThrValGluSerIleAla-309 314-SerTyrAlaAspGluLeuAspGlyTyrGlyLysVal-325 336-SerIleTyrAlaGlyLeuSerGluIleSerAlaGlyLys-348 Antigenic Index - Jameson-Wolf 7-AsnSerLeuLysGlnLeuGlnGluGluArgIleArgGlnGluArgIleArgGlnGluArgIleArgGlnAlaAr gGlyAsnLeu-34 36-SerValAsnArgLysGlnArgGluAlaTrpAspLysPheGlnLysLeuAsnThrGluLeuAsnArgLeuLysT hrGluValAlaAla-64 74-SerGlyAsnTyrLysAsnSerArgProAsnAla-84 91-AsnAlaGluProGlyGlnLysAsnArgPhe-100 107-ValAsnAlaSerAsnArgGluValValLysAspLeuGluLysGlnGlnLys-123 128-GlnGluGlnLysIleAsnAsnGluLeuAlaArgLeuLysLysIleGln-143 149-LeuLeuLysLysGlnGlyValThrAspAlaAlaGluGlnThrGluSerArgArgGlnAsnAlaLysIleSer LysAspAlaArgLysLeuLeuGluGlnLysGlyAsnGluGlnGlnLeu-188 191-LeuLeuSerAsnLeuGluLysLysLysAlaGluHisArgIleGlnAspAlaGluAlaLysArgLysLeuAla GluAlaLysLeuAlaAlaAlaGluLysAlaArgLysGluAlaAlaGlnGlnLysAlaGluAlaArgArgAlaGluM etSerAsnLeuThrAlaGluAspArgAsnIleGlnAlaProSer-254 259-GlySerAlaAspGlyPheSerArgMetGlnGlyArgLeuLysLysProValAspGlyValProThr-280 284-GlyGlnAsnArgSerGlyGlyAspVal-292 314-SerTyrAlaAspGluLeuAspGlyTyrGly-323 329-AspHisGlyGluAsnTyr-334 343-GluIleSerAlaGlyLysGlyTyrThr-351 354-AlaGlySerLysIleGlyThrSerGlySerLeuProAspGlyGluGluGlyLeu-371 375-IleArgTyrArgGlyGlnValLeuAsnProSerGlyTrp-387 Hydrophilic Regions - Hopp-Woods 7-AsnSerLeuLysGlnLeuGlnGluGluArgIleArgGlnGluArgIleArgGlnGluArgIleArgGlnAlaAr gGlyAsn-33 37-ValAsnArgLysGlnArgGluAlaTrpAspLysPheGlnLysLeuAsnThrGluLeuAsnArgLeuLysThrG luValAlaAla-64 77-TyrLysAsnSerArgProAsn-83 91-AsnAlaGluProGlyGlnLysAsnArgPhe-100 llO-SerAsnArgGluValValLysAspLeuGluLysGlnGlnLys-123 128-GlnGluGlnLysIleAsnAsnGluLeuAlaArgLeuLysLysIleGln-143 149-LeuLeuLysLysGlnGlyValThrAspAlaAlaGluGlnThrGluSerArgArgGlnAsnAlaLysIleSer LysAspAlaArgLysLeuLeuGluGlnLysGlyAsnGluGlnGlnLeu-188 193-SerAsnLeuGluLysLysLysAlaGluHisArgIleGlnAspAlaGluAlaLysArgLysLeuAlaGluAla LysLeuAlaAlaAlaGluLysAlaArgLysGluAlaAlaGlnGlnLysAlaGluAlaArgArgAlaGluMet-240 244-ThrAlaGluAspArgAsnIleGln-251 267-MetGlnGlyArgLeuLysLysProValAsp-276 286-AsnArgSerGlyGlyAspVal-292 315-TyrAlaAspGluLeuAspGlyTyrGly-323 356-SerLysIleGlyThr-360 363-SerLeuProAspGlyGluGluGlyLeu-371 g601 AMPHI Regions - AMPHI 7-LeuValAspGluIleAspValProAsnIleGlyArg-18 26-AlaGlyIleProThrValPhe-32 42-GlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluThrIleArgAlaTyrG lyAlaLeu-68 70-MetGlyLeuIleSerAspValSerGlu-78 100-SerSerGlyLysThrValAsn-106 137-AlaValLeuGlyThrLeuValAsnLeuAlaAla-147 167-GlyAlaAlaAlaGlu-171 Antigenic Index - Jameson-Wolf 3-ProThrGlyAsnLeuValAspGluIleAspValProAsnIleGlyArgLeuLys-20 39-GlyTyrThrGlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluThr-61 75-AspValSerGluAlaAlaAlaArgAlaArgThrProLysProAlaPhe-90 97-TyrThrAlaSerSerGlyLysThrValAsn-106 108-AlaAspIleAspLeuProVal-114 147-AlaGlyGlyGlyThrArgLysGluValArgPheGlyHisProSerGlyThrLeuArg-165 170-AlaGluCysGlnAspGlyGln-176 183-ValMetSerArgSerAlaArgValIle-191 196-ValArgValProAspAspCysPhe-203 Hydrophilic Regions - Hopp-Woods 7-LeuValAspGluIleAspVal-13 40-TyrThrGlyLysGluLeuGlnAspAspIleAsnAsnAspAlaAlaAlaLeuGluLysPheGluThr-61 75-AspValSerGluAlaAlaAlaArgAlaArgThrProLys-87 99-AlaSerSerGlyLysThrValAsn-106 108-AlaAspIleAspLeuProVal-114 149-GlyGlyThrArgLysGluValArgPhe-157 170-AlaGluCysGlnAsp-174 186-ArgSerAlaArgValIle-191 198-ValProAspAspCysPhe-203 g602 AMPHI Regions - AMPHI 54-ArgGlnValAlaGlnIle-59 61-AlaGlyLeuHisValCysAsnGlyVal-69 Antigenic Index - Jameson-Wolf 5-GlnCysAspLysAlaArgHisMetArgPro-14 17-LeuGlyGlyGlnIleAsnArgHisArgGlnAlaSerAsnArgGlyLeuCys-33 35-PheGlyGlyPheGlnGlyAsnArgGluAlaGln-45 51-LeuIleAspArgGlnVal-56 88-GlyArgGlnMetProSerGluLysThrLeu-97 103-GlnMetArgAspTyr-107 Hydrophilic Regions - Hopp-Woods 5-GlnCysAspLysAlaArgHisMet-12 21-IleAsnArgHisArgGlnAlaSerAsnArgGly-31 39-GlnGlyAsnArgGluAlaGln-45 51-LeuIleAspArgGlnVal-56 91-MetProSerGluLysThrLeu-97 g603 AMPHI Regions - AMPHI 119-MetLeuLeuAsnGluLeuGluLys-126 131-AspArgIleLysAlaIleGlyArgArgIleAlaHisGlyGlyGluLysTyr-147 157-ValLeuAspGluLeuLysAlaCysIlePro-166 171-HisAsnProAlaAsnIleSerGlyIleLeuAla-181 185-HisPheProGlyLeuProAsnValGly-193 198-SerPheHisGlnThrMetPro-204 211-AlaValProArgGluLeu-216 238-GluAlaAlaArgIleLeuGlyLysProLeuGluAspIleArgMetIleIleAlaHis-256 259-AsnGlyAlaSerIleThrAlaValLysAsnGlyLysSerVal-272 279-ThrProIleGluGly-283 298-TyrSerTyrProThr-302 323-ProGlyIleSerGluLeuProAsnAspCysArgThr-334 356-ArgLeuAlaLysTyrIleAlaSerMetAla-365 392-ValSerTyrLeuAsp-396 Antigenic Index - Jameson-Wolf l-MetAspSerArgLeuArgGlyAsnAspAlaArgLysTyrGly-14 17-PheAlaGlnArgGlyArgLeuLysHisThrProProAsnAlaHisProPheSerAspGlyProAlaProLysL ysGlnProGlnThrThrArgArgAsnIleMe Ser-52 64-SerSerLeuLysGlyAlaValIleAspArgLysSerGlySer-77 83-LeuGlyGluArgLeuThrThrProGluAla-92 95-ThrPheAsnLysAspGlyAsnLysArgGlnValProLeuSerGlyArgAsnCysHis-113 123-GluLeuGluLysHisGlyLeuHisAspArgIleLysAlaIleGlyArgArgIleAlaHisGlyGlyGluLys TyrHisGlu-149 151-ValLeuIleAspGlnAspValLeuAspGluLeuLysAla-163 202-ThrMetProGluArgAlaTyr-208 214-ArgGluLeuArgLysLysTyrAlaPheArgArgTyrGlyPheHisGlyThrGlyMet-232 238-GluAlaAlaArgIleLeuGlyLysProLeuGluAspIleArg-251 257-LeuGlyAsnGlyAla-261 264-ThrAlaValLysAsnGlyLysSerValAspThrGlyMet-276 288-ThrArgCysGlyAspThrAspProGlyVal-297 310-AlaGlnValAspGluMetLeuAsnGluLysSerGlyPheProGlyIleSerGluLeuProAsnAspCysArg ThrLeuGluIleAlaAlaAspGluGlyArgGluGlyAlaArgLeu-348 379-GlyIleGlyGluAsnSerArgAsnIleArgAlaLysThr-391 402-IleAspThrLysAlaAsnMetGluLysArgTyrGlyAsnSerGlyIle-417 4].9-SerProThrAspSerSerPro-425 431-ProThrAsnGluGluLeu-436 Hydrophilic Regions - Hopp-Woods l-MetAspSerArgLeuArgGlyAsnAspAlaArgLysTyrGly-14 17-PheAlaGlnArgGlyArgLeuLysHisThrPro-27 34-SerAspGlyProAlaProLysLysGlnProGlnThrThrArgArgAsnIleMet-51 69-AlaValIleAspArgLysSerGly-76 83-LeuGlyGluArgLeuThrThr-89 96-PheAsnLysAspGlyAsnLysArgGlnValProLeuSerGlyArgAsnCysHis-113 123-GluLeuGluLysHisGlyLeuHisAspArgIleLysAlaIleGlyArgArgIleAlaHisGlyGlyGluLys TyrHisGlu-149 156-AspValLeuAspGluLeuLysAla-163 203-MetProGluArgAlaTyr-208 214-ArgGluLeuArgLysLysTyrAlaPhe-222 238-GluAlaAlaArgIleLeuGlyLysProLeuGluAspIleArg-251 267-LysAsnGlyLysSerValAspThr-274 289-ArgCysGlyAspThrAspPro-295 310-AlaGlnValAspGluMetLeuAsnGluLysSerGly-321 328-LeuProAsnAspCysArgThrLeuGluIleAlaAlaAspGluGlyArgGluGlyAlaArgLeu-348 380-IleGlyGluAsnSerArgAsnIleArgAlaLysThr-391 402-11eAspThrLysAlaAsnMetGluLysArgTyrGly-413 432-ThrAsnGluGluLeu-436 g604 AMPHI Regions - AMPHI 35-SerValValGlnPheAla-40 49-IleAspValGlyGlyValTyrGly-56 98-AspGlyPheLysPhePheGln-104 lll-AspValValLeuGlnLeuPheAlaArgValAlaGlnValGlyGlyValGlnGluAsn-129 146-ArgHisIleAsnPheValAspGlnIleAlaGlyTrpGlu-158 Antigenic Index - Jameson-Wolf 10-SerAlaAlaCysGlyLysValAspGlnArgThrGluHisGlyGlyGlyAspGlyAspArgGlyAspAlaHis- 33 44-GlyAlaTyrArgGlnIleAspVal-51 65-GlyGlyGlyArgAspGluGlyGlyPheArgArgAlaArgAlaGlyGlyGlyPhe-82 95-IleCysAlaAspGly-99 101-LysPhePheGlnArgGlyGlyIle-108 125-GlyValGlnGluAsnGlyArgAsnAlaArgValAspGluArgGlyPheGln-141 Hydrophilic Regions - Hopp-Woods 14-GlyLysValAspGlnArgThrGluHisGlyGlyGlyAspGlyAspArgGlyAspAlaHis-33 66-GlyGlyArgAspGluGlyGlyPheArgArgAlaArgAla-78 125-GlyValGlnGluAsnGlyArgAsnAlaArgValAspGluArgGlyPhe-140 g605 AMPHI Regions - AMPHI 13-ArgGlnIleTrpLysIleAlaAsp-20 38-ThrLeuPheTyrArgPheIleSerGluAsnPheThrAspTyrMetGln-53 107-LysLeuLysGluIlePheThrAlaIle-115 126-GlnGlyIleLysGlyLeuPheAspAspPheAsp-136 141-ArgLeuGlySerThr-145 155-AlaValLeuLysGlyValAlaGluLeu-163 178-AspAlaTyrGluTyrLeuIleSerAsn-186 188-AlaAlaAsnAlaGlyLys-193 204-ValSerLysLeuIleAlaArg-210 217-GluLysValAsnLysIleTyrAspPro-225 240-PheAspGluHisIle-244 291-AspSerLysProPheAspAlaValValSerAsn-301 341-HisAlaLeuAsnTyr-345 355-ValSerPheProGly-359 433-GluHisIleAlaGluIleValLysLeuPheAla-443 452-AlaGlnAsnAlaAlaGlnGlnThr-459 478-ThrArgGluValIleAspIle-484 489-AlaGluIleSerGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAlaGluIle Glu-513 Antigenic Index - Jameson-Wolf 5-MetGlnGlnArgAlaGlnLeu-ll 18-IleAlaAspGluValArgGlyAlaValAspGlyTrpAsp-30 44-IleSerGluAsnPheThrAspTyrMetGlnAlaGlyAspSerSerIleAsp-60 63-AlaMetProAspSer-67 71-ProGluIleLysAspAspAlaValLysVal-80 98-AlaHisGlnAsnGluGluLeuAsnThrLysLeuLysGlu-110 116-GluSerSerAlaSerGlyTyrProSerGluGlnGlyIleLysGlyLeuPheAspAspPheAspThrThrSer SerArgLeu-142 146-ValAlaAspLysAsnLysArgLeu-153 164-AspPheGlyAsnPheGluAspHisArgIle-173 190-AsnAlaGlyLysSerGlyGlyGluPhePheThr-200 215-GlyGlnGluLysValAsnLysIleTyrAspProAlaCysGlySerGlySer-231 235-GlnAlaLysLysGlnPheAsp-241 253-GluIleAsnHisThrThrTyrAsn-260 280-LeuGlyAspThrLeuThrAsnProLysLeuLysAspSerLysProPheAspAla-297 309-IleGlySerAspAspProThrLeuIleAsnAspAspArgPheAlaPro-324 330-ProLysSerLysAlaAsp-335 345-TyrLeuSerGlyArgGlyArgAlaAla-353 362-TyrArgGlyGlyAlaGluGlnLysIleArg-371 403 -LeuSerLysHisLysAspAsnThrAsp-411 419-GlyPhePheLysLysGluThrAsnAsnAsnValLeuThrGluGluHisIle-435 442-PheAlaAspLysAlaAspVal-448 458-GlnThrValLysAspAsnGlyTyr-465 473-ValGluAlaGluAspThrArgGluValIleAsp-483 490-GluIleSerGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAlaGluIleGlu Thr-514 Hydrophilic Regions - Hopp-Woods 18-IleAlaAspGluValArgGlyAlaValAsp-27 55-GlyAspSerSerIle-59 71-ProGluIleLysAspAspAlaValLysVal-80 98-AlaHisGlnAsnGluGluLeuAsnThrLysLeuLysGlu-110 131-LeuPheAspAspPheAspThrThrSerSerArgLeu-142 146-ValAlaAspLysAsnLysArgLeu-153 167-AsnPheGluAspHisArgIle-173 191-AlaGlyLysSerGlyGly-196 215-GlyGlnGluLysValAsnLysIleTyrAsp-224 235-GlnAlaLysLysGlnPheAsp-241 287-ProLysLeuLysAspSerLysProPhe-295 310-GlySerAspAspProThrLeuIleAsnAspAspArgPheAla-323 330-ProLysSerLysAlaAsp-335 348-GlyArgGlyArgAla-352 364-GlyGlyAlaGluGlnLysIleArg-371 404-SerLysHisLysAspAsnThrAsp-411 419-GlyPhePheLysLysGluThrAsn-426 430-LeuThrGluGluHisIle-435 442-PheAlaAspLysAlaAspVal-448 458-GlnThrValLysAspAsnGly-464 473-ValGluAlaGluAspThrArgGluValIleAsp-483 490-GluIleSerGluThrValAlaLysIleGluArgLeuArgArgGluIleAspGluValIleAlaGluIleGlu Thr-514 g606 AMPHI Regions - AMPHI 72-LeuLeuAspHisMetThrArgAspGlu-80 90-AlaHisValGlyAsnGlyAsp-96 100-LeuThrLeuIleGlnGlyValValAsnThrPhe-110 116-ArgIleIleAlaAsn-120 139-SerMetValPheGlnIleLeuPheGlyPheLeuAlaSerLeuIleVal-154 171-LysLeuValGlyAlaProLysMetIleSerAlaLeuGlnArg-184 191-AspLeuProGluGluMetAsnAla-198 Antigenic Index - Jameson-Wolf 13-GluValIleAspThrProArgThrGluGluGluAla-24 31-GluAlaGlnAlaArgGlnTrpAsnLeuLysThrProGlu-43 48-HisSerProGluProAsnAla-54 57-ThrGlyAlaSerArgAsnSerSer-64 75-HisMetThrArgAspGluValGluAla-83 92-ValGlyAsnGlyAsp-96 122-IleAlaArgAsnAsnAspGlySerGlnSerGlnGlyThr-134 159-ArgGlnArgGluTyrArgAlaAspAlaGlyAla-169 182-LeuGlnArgLeuLysGlyAsnProValAspLeuProGluGluMetAsn-197 203-GlyAspThrArgAspSerLeuLeuSerThrHisProSerLeuAspAsnArgIleAlaArgLeuLysSer-22 5 Hydrophilic Regions - Hopp-Woods 13-GluValIleAspThrProArgThrGluGluGluAla-24 59-AlaSerArgAsnSer-63 75-HisMetThrArgAspGluValGluAla-83 124-ArgAsnAsnAspGlySerGlnSer-131 159-ArgGlnArgGluTyrArgAlaAspAlaGlyAla-169 183-GlnArgLeuLysGlyAsnPro-189 191-AspLeuProGluGluMetAsn-197 203-GlyAspThrArgAspSerLeu-209 214-ProSerLeuAspAsnArgIleAlaArgLeuLysSer-225 g607 AMPHI Regions - AMPHI 15-LysGluIleArgLeuLeuThrAlaLeuAlaLeu-25 70-PheMetGlyIleMetAlaAlaLeuAsnProMetIleAlaGln-83 90-ThrGlyGluAlaGlyGlu-95 104-GlyLeuIleLeuGlyIlePheGlyMetIleLeuMetTrpAlaAlaIleThrProPheArgAsnTrpLeuThr LeuSerAspTyrValGluGlyThrMet-136 151-MetValHisArgAlaLeuHisAlaTyrAlaSerSer-162 226-PhePheArgProPheGly-231 244-PheLysGlnIleTrpLysIleGlyAla-252 320-AlaArgTyrIleSerGlyValSerLeu-328 337-IleThrValLeuSerLeuVal-343 348-ProLeuAlaSerMetTyr-353 373-PheGlnProAlaAspPheThrGlnCysIleAlaSerTyrAla-386 424-TyrGlyPheTrpThrAlaLeuIleAla-432 Antigenic Index - Jameson-Wolf 4-AspLeuAspArgPheSer-9 47-GlyAlaGlyLysGluAspLeuAla-54 86-GlyAlaGlyLysThrGlyGluAlaGlyGluThrGlyArgGln-99 121-ProPheArgAsnTrp-125 128-LeuSerAspTyrValGluGlyThr-135 160-AlaSerSerLeuAsnArgProArgLeu-168 222-AlaLysGluLysPhePheArg-228 234-AlaLysPheGlyLysProAspTrp-241 311-SerLeuGlyArgArgGluPheSerArgAlaArgTyrIleSer-324 348-ProLeuAlaSerMetTyrAsnAspAspProAla-358 388-ArgGlyTyrLysValThrLys-394 452-LeuValLysSerHisLysAlaVal-459 Hydrophilic Regions - Hopp-Woods 47-GlyAlaGlyLysGluAspLeuAla-54 89-LysThrGlyGluAlaGlyGluThrGlyArg-98 163-LeuAsnArgProArg-167 222-AlaLysGluLysPhePhe-227 312-LeuGlyArgArgGluPheSerArg-319 353-TyrAsnAspAspProAla-358 390-TyrLysValThrLys-394 452-LeuValLysSerHisLysAlaVal-459 g608 AMPHI Regions - AMPHI 66-AlaIleArgLysIleLeuGln-72 93-ValLeuSerLeuLeu-97 103-ArgAlaSerAspGluLeuAlaArgIlePheGlyThr-114 124-AspIleGlyHisGlyIleLysGlnIleGlyArgAsnIleAlaGluGlnIleGlyGlyPheSerArgGluPro GluSerAlaAsnThrGlyAsnGluAlaLeuAlaAspCysLeuAspGluIleSerArgLeuArgAspGlyValGluA rgLeuAsnGluArgLeuAspArgLeu-181 Antigenic Index - Jameson-Wolf 13-LeuGlnSerProAspSerArgSerGluLeuThr-23 39-LeuAlaGlyArgIleThrGluAspGlyLeuLeuSerAlaGlyAsnGlyPheAlaAspThrGluIleThrPheA rgAsnSerAlaIleArgLysIleLeuGlnGlyGlyGluProGlyAlaGlyAspIleArgLeuGluGly-85 98-GlySerLeuArgSerArgAlaSerAspGluLeuAla-109 116-AlaGlyIleGlySerArgAlaThrAspIle-125 130-LysGlnIleGlyArgAsnIleAla-137 140-IleGlyGlyPheSerArgGluProGluSerAlaAsnThrGlyAsnGluAlaLeuAlaAspCysLeuAspGlu IleSerArgLeuArgAspGlyValGluArgLeuAsnGluArgLeuAspArgLeuGluArgAspIleTrp-186 Hydrophilic Regions - Hopp-Woods 15-SerProAspSerArgSerGluLeu-22 39-LeuAlaGlyArgIleThrGluAspGlyLeu-48 56-AlaAspThrGluIleThrPhe-62 65-SerAlaIleArgLysIleLeuGln-72 74-GlyGluProGlyAlaGlyAspIleArgLeuGluGly-85 100-LeuArgSerArgAlaSerAspGluLeuAla-109 118-IleGlySerArgAlaThrAsp-124 143-PheSerArgGluProGluSerAlaAsnThrGlyAsnGluAlaLeuAlaAspCysLeuAspGluIleSerArg LeuArgAspGlyValGluArgLeuAsnGluArgLeuAspArgLeuGluArgAspIleTrp-186 g609 AMPHI Regions - AMPHI 15-ThrLeuAspAlaPheVal-20 30-HisHisIlePheHisGluPheArgValPheValGlyLeuPhe-43 52-PheGluGlnAlaValGlu-57 67-IleAspAsnPheLeu-71 114-ValAlaValCysProVal-119 Antigenic Index - Jameson-Wolf 10-AlaLeuAspAspGluThrLeu-16 20-ValGlyAsnGlnArgSerSerAspIleAla-29 71-LeuAspThrAspPheGlyIleGlySerGlnAlaAspGlyAsnValArg-86 99-GlyThrArgAlaLysArgGlyTyrGlyAsnHisAspLeu-lll 124-ArgGluAlaAspIle-128 Hydrophilic Regions - Hopp-Woods 10-AlaLeuAspAspGluThrLeu-16 23-GlnArgSerSerAspIle-28 79-SerGlnAlaAspGlyAsnVal-85 100-ThrArgAlaLysArgGlyTyrGly-107 124-ArgGluAlaAspIle-128 g610 AMPHI Regions - AMPHI 6-MetGlnPheProTyrArg-11 18-MetArgArgMetArgArg-23 97-ThrGlyArgAlaGlnGluAlaTyr-104 lll-ProSerThrValArgAlaLeuArgGluArg-120 187-IleArgGluAlaLeuGlu-192 208-TyrAlaSerAlaPheTyrGlyProPheArgAsp-218 223-SerGlyAsnLeuGlyLysAlaAsp-230 268-LeuAspValValArgArgValLysAspGlu-277 296-AlaAlaValAlaAsn-300 Antigenic Index - Jameson-Wolf ll-ArgAsnValProAlaSerArgMetArgArgMetArgArgAspAspPheSerArgArgLeuMetArg-32 34-HisMetLeuThrAlaAspAsp-40 50-GlyAlaAlaArgGluGluAspValProSerMetProGlyValLysArgGlnSerLeuAsp-69 75-AlaGluGluAlaValLys-80 93-ThrAlaAsnLysThrGlyArgAlaGlnGluAlaTyrAsnProGluGlyLeuVal-110 115-ArgAlaLeuArgGluArgPhePro-122 139-GlyGlnAspGlyLeuThrAspGluAsnGlyTyrValMetAsnAspGluThrVal-156 175-AlaProSerAspMetMetAspGlyArgIleGlyAlaIleArgGluAlaLeuGluAspAlaGlyHis-196 215-ProPheArgAspAlaValGlySerSerGlyAsnLeuGlyLysAlaAspLysLysThrTyrGlnMetAspPro AlaAsnThrAspGluAlaLeuHis-246 250-LeuAspIleGlnGluGlyAlaAsp-257 270-ValValArgArgValLysAspGluPheGlyVal-280 302-TrpLeuAspGlyGlyLysValVal-309 317-LysArgAlaGlyAlaAspGly-323 331-GluAlaAlaLysMetLeuLysArg-338 Hydrophilic Regions - Hopp-Woods 14-ProAlaSerArgMetArgArgMetArgArgAspAspPheSerArgArgLeuMetArg-32 34-HisMetLeuThrAla-38 50-GlyAlaAlaArgGluGluAspValProSer-59 61-ProGlyValLysArgGlnSerLeuAsp-69 75-AlaGluGluAlaValLys-80 95-AsnLysThrGlyArgAlaGlnGluAlaTyrAsn-105 115-ArgAlaLeuArgGluArgPhePro-122 141-AspGlyLeuThrAspGluAsnGly-148 151-MetAsnAspGluThrVal-156 178-AspMetMetAspGlyArgIleGlyAlaIleArgGluAlaLeuGluAspAlaGly-195 216-PheArgAspAlaValGly-221 225-AsnLeuGlyLysAlaAspLysLysThrTyrGln-235 238-ProAlaAsnThrAspGluAlaLeuHis-246 250-LeuAspIleGlnGluGlyAlaAsp-257 270-ValValArgArgValLysAspGluPheGly-279 317-LysArgAlaGlyAla-321 331-GluAlaAlaLysMetLeuLysArg-338 gβll AMPHI Regions - AMPHI 15-CysArgLeuPheGlyLysLeuSerLeu-23 26-ArgLeuLeuProGlyLeuCysArgGly-34 48-ArgSerValArgArgValIle-54 63-GlnValValAlaVal-67 104-ValPheIleGluAspPheVal-llO 130-GlyPheLeuGlyAsnValLeuArgThr-138 Antigenic Index - Jameson-Wolf l-MetProSerGluAsnGlyMetGlyLysArgGlnLeuAla-13 29-ProGlyLeuCysArgGlyGlyValCysArgGlyArgCys-41 45-PheProSerArgSerValArgArgVal11ePheArgArgValArgl1e-60 119-AsnProAlaAspPheArgVal-125 142-AlaProGlnGluAsp-146 Hydrophilic Regions - Hopp-Woods l-MetProSerGluAsnGlyMetGlyLysArgGlnLeuAla-13 35-GlyValCysArgGlyArgCys-41 53-ValIlePheArgArgValArgIle-60 121-AlaAspPheArgVal-125 g612 AMPHI Regions - AMPHI 6-AsnIleAlaLysLysLeuAlaGlyVal-14 57-LysAlaValGluLysCysAlaGluAsnValLeu-67 80-ValGlyAspPheProAsn-85 Antigenic Index - Jameson-Wolf 7-IleAlaLysLysLeuAlaGlyValAsp-15 17-IleAlaPheAspPheAspGly-23 27-AspPheGlyArgAspAspAlaValArgHisSerGlyVal-39 57-LysAlaValGluLysCysAlaGlu-64 98-HisHisArgAsnProTyrIleLysLeuAsnLysSerLysSerProAspIlePheArg-116 119-PheTyrGlyHisSerAsn-124 Hydrophilic Regions - Hopp-Woods 7-IleAlaLysLysLeuAlaGlyValAsp-15 28-PheGlyArgAspAspAlaValArg-35 57-LysAlaValGluLysCysAlaGlu-64 105-LysLeuAsnLysSerLysSerProAspIlePhe-115 g613 AMPHI Regions - AMPHI 95-MetProArgMetArgSerProSerSerLeuMetSerProAla-108 140-SerSerValMetArgProAla-146 166-GluArgLeuSerGlyLeuCysArgIle-174 184-Aspl1ePheSerAspTrpGly-190 Antigenic Index - Jameson-Wolf l-MetSerArgSerSerLeuSerArgArgSerLeuArgArgSerThrProSerArg-18 23-SerSerArgGlnSerAlaArgAla-30 36-AlaAspSerGlySerArgGluAsnProProIleCysSer-48 73-ProLysIleArgAlaAsnSerSerAspAlaArgGluArgArgLeuProSerArgAspSerThrAla-94 96-ProArgMetArgSerProSerSerLeu-104 107-ProAlaProGlySerProPro-113 130-AlaLysProPheProAlaGluSerLysProSerSerValMetArgProAlaSer-147 159-ProAlaLysGluValSerSerGluArgLeuSerGlyLeuCysArgIleArgArg-176 178-MetMetGlyArgArgAlaAspIlePheSerAspTrpGlyGlyGluCys-193 Hydrophilic Regions - Hopp-Woods 1-MetSerArgSerSerLeuSerArgArgSerLeuArgArgSerThrProSer-17 24-SerArgGlnSerAlaArgAla-30 38-SerGlySerArgGluAsnProPro-45 73-ProLysIleArgAlaAsnSerSerAspAlaArgGluArgArgLeuProSerArgAspSerThrAla-94 96-ProArgMetArgSerProSer-102 133-PheProAlaGluSerLysProSerSerValMetArg-144 159-ProAlaLysGluValSerSerGluArgLeuSerGly-170 172-CysArgIleArgArg-176 178-MetMetGlyArgArgAlaAspIle-185 g614 AMPHI Regions - AMPHI 20-SerGlnPheIleArgGlnValAsnAsnGly-29 65-AsnLeuIleGlnThrLeuLeuAsn-72 90-AlaLeuPheTyrSerLeuLeuProValLeu-99 144-ValAlaGlyCysAspGluAlaLysGluGluValGlnGluIleValAspTyrLeuLysAlaProAsnArgTyr GlnSerLeu-170 210-AspPheValGluMetPheVal-216 222-ArgValArgAspMetPheGluGln-229 242-GluIleAspAlaValGlyArg-248 295-ProAlaLeuGlnArgProGlyArgPheAsp-304 333-SerValAspLeuLeuSerLeuAla-340 349-AlaAspLeuAlaLysLeuVal-355 Antigenic Index - Jameson-Wolf 7-LeuAspGlyLysLysGluAspAsnGlyGlnIleGlu-18 25-GlnValAsnAsnGlyGluValSerGly-33 45-LeuIleLysGlyGluArgThrAspLysSerThrPhe-56 59-AsnAlaProLeuAspAspAsnLeu-66 70-LeuLeuAsnLysAsnValArgValLysValThrProGluGluLysProSerAla-87 112-GlnAlaGlyGlyGlyGlyLysGlyGly-120 123-SerPheGlyLysSerArgAlaArgLeuLeuAspLysAspAlaAsnLys-138 145-AlaGlyCysAspGluAlaLysGluGluValGlnGlu-156 161-LeuLysAlaProAsnArgTyrGlnSerLeuGlyGlyArgValProArgGly-177 182-GlySerProGlyThrGlyLysThrLeuLeu-191 207-SerGlySerAspPhe-211 219-GlyAlaSerArgValArgAspMetPheGluGlnAlaLysLysAsnAla-234 241-AspGluIleAspAlaValGlyArgGlnArgGlyAlaGlyLeuGlyGlyGlyAsnAspGluArgGluGlnThr Leu-265 272-MetAspGlyPheGluSerAsnGln-279 287-ThrAsnArgProAspValLeuAspProAlaLeuGlnArgProGlyArgPheAspArg-305 311-LeuProAspIleArgGlyArgGluGlnXxx-320 323-ValHisSerLysLysValProLeuAspGluSerValAsp-335 341-ArgGlyThrProGlyPheSerGly-348 362-AlaGlyArgArgAsnLysValLysValAspGlnSerAspLeuLysThrProLysThrLysSer-382 Hydrophilic Regions - Hopp-Woods 7-LeuAspGlyLysLysGluAspAsnGlyGln-16 26-ValAsnAsnGlyGluValSer-32 46-1leLysGlyGluArgThrAspLysSerThr-55 61-PrOLeuAspAspAsnLeu-66 73-LysAsnValArgValLysValThrProGluGluLysProSerAla-87 115-GlyGlyGlyLysGlyGly-120 125-GlyLysSerArgAlaArgLeuLeuAspLysAspAlaAsnLys-138 145-AlaGlyCysAspGluAlaLysGluGluValGlnGlu-156 162-LysAlaProAsnArg-166 171-GlyGlyArgValProArg-176 221-SerArgValArgAspMetPheGluGlnAlaLysLysAsnAla-234 241-AspGluIleAspAlaValGlyArgGlnArgGlyAlaGly-253 256-GlyGlyAsnAspGluArgGluGlnThr-264 273-AspGlyPheGluΞer-277 287-ThrAsnArgProAspValLeuAsp-294 296-AlaLeuGlnArgProGlyArgPheAspArg-305 312-ProAspIleArgGlyArgGluGlnXxx-320 324-HisSerLysLysValProLeuAspGluSerValAsp-335 362-AlaGlyArgArgAsnLysValLysValAspGlnSerAspLeuLysThrProLysThrLys-381 g616 AMPHI Regions - AMPHI 6-LysMetValValGlyLeu-ll 13-AsnProGlyLysGluTyrGlu-19 48-PheGlyGluValAlaArgAla-54 77-ValAlaAlaLeuAlaGlnPheTyrLys-85 115-GlyHisAsnGlyLeuLysAspIle-122 152-LeuAsnLysProSerAla-157 177-HisHisPheArgGlnMetGlyArg-184 203-ThrAlaPheSerArgPheProTyr-210 267-AlaProValGlnAsnLeuProAsnValAla-276 299-GlyGlyIleTyrSerLeuLeuPhe-306 319-PheAspLysAlaAla-323 363-GluCysAlaGlnAlaTrp-368 374-ThrGlySerLeuGlyAspValLeuAlaAspLeuThr-385 Antigenic Index - Jameson-Wolf H-LeuGlyAsnProGlyLysGluTyrGluGlnThrArgHisAsnAlaGlyPhe-27 39-AlaSerPheLysGluGluLysLysPhePhe-48 55-AlaLeuProAspGly-59 70-MetAsnArgSerGlyGlnAla-76 86-IleLysProGluGlu-90 96-AspGluLeuAspIleProCysGlyArgIleLysPhe-107 109-LeuGlyGlyGlyAsnGlyGlyHisAsnGlyLeuLysAspIleGlnAla-124 138-IleGlyHisProGlyAspArgAsnLeu-146 152-LeuAsnLysProSerAlaGluAlaProProAlaAsnArgArgCysArgArgGlnIleProAlaGlyArgThr ArgHisHisPheArgGlnMetGlyArgGlyAsnAlaLeu-188 197-ArgLeuLysProPheGlnThrAla-204 209-ProTyrProAsnSerHisGluArgThrGlnAla-219 221-TyrProAsnGlyIleHisProArgHisArgArgAsnProArgPheProAla-237 239-ArgMetGlnHisArgArgSerThrValArgArgArgSerGlyThrMetAlaArgHisThrCysArgThrArg ArgGlnIle-265 275-ValAlaGlyArgGlyGlyGlyMetLysLeuProArgAsnArgPhe-289 308-AlaAlaAspThrAlaProProPro-315 317-ProHisPheAspLysAlaAla-323 338-AlaPheLysThrGlyLysLeuProIlePro-347 371-AlaThrArgThrGlySerLeuGly-378 394-AlaArgSerAlaCysArgProAsp-401 Hydrophilic Regions - Hopp-Woods 13-AsnProGlyLysGluTyrGluGlnThrArgHis-23 39-AlaSerPheLysGluGluLysLysPhePhe-48 86-IleLysProGluGlu-90 96-AspGluLeuAspIleProCysGlyArgIleLysPhe-107 117-AsnGlyLeuLysAspIleGlnAla-124 140-HisProGlyAspArgAsnLeu-146 155-ProSerAlaGluAlaProProAlaAsnArgArgCysArgArgGlnIleProAlaGlyArgThrArgHisHis Phe-179 212-AsnSerHisGluArgThrGln-218 225-IleHisProArgHisArgArgAsnProArg-234 240-MetGlnHisArgArgSerThrValArgArgArgSerGlyThrMet-254 257-HisThrCysArgThrArgArgGlnIle-265 276-AlaGlyArgGlyGlyGly-281 283-LysLeuProArgAsnArgPhe-289 308-AlaAlaAspThrAla-312 318-HisPheAspLysAlaAla-323 338-AlaPheLysThrGlyLys-343 396-SerAlaCysArgProAsp-401 g619 AMPHI Regions - AMPHI 50-LysLeuAlaAlaLeuLeu-55 66-GlnLeuPheGlnThrLeuThrAsn-73 146-GlyValIlePheGlyIleLeuPheArgSerLeuSerSerLeuLeuSerArg-162 165-AspProGluGluPhe-169 175-AsnMetPheAlaGlyPheAsn-181 246-AlaValValGlyProValSerPhePheGlyLeuLeuAlaAlaSerLeuAlaAsnHisPheSer-266 303-LeuSerValValValGluPhe-309 Antigenic Index - Jameson-Wolf l-MetProSerGluLysAsnIle-7 12-GlySerSerArgProLeuArg-18 35-AsnValLysGlyAspTrpAsp-41 132-IleArgGlnGlyGlyArgAspLeuPro-140 163-MetIleAspProGluGluPheThr-170 182-ThrValArgSerGluLeu-187 205-GluArgTyrArgSerAspValHisLeuLeuGlyArgAspGlnAlaVal-220 265-PheSerProSerValArgHisSerVal-273 Hydrophilic Regions - Hopp-Woods l-MetProSerGluLysAsnIle-7 13-SerSerArgProLeu-17 134-GlnGlyGlyArgAspLeuPro-140 163-MetIleAspProGluGluPheThr-170 183-ValArgSerGluLeu-187 205-GluArgTyrArgSerAspVal-211 213-LeuLeuGlyArgAspGlnAla-219 269-ValArgHisSerVal-273 g620 AMPHI Regions - AMPHI 8-IleValAlaValPheAlaLeuSerAla-16 31-IleSerAspArgSerVal-36 69-ValLysGlnMetPheGlyTyrThrLysLeuProGluGluProLysGlyIleArgValIleTyrValThrAspM etGlyAsnValThrAspTrpThr-100 139-GlnAlaGluLysPhe-143 Antigenic Index - Jameson-Wolf 16-AlaCysArgGlnAlaGluGluAlaProProProLeuProArgGlnIleSerAspArgSerValGlyHisTyrC ysSerMetAsnLeuThrGluHisAsnGlyProLysAla-52 56-LeuAsnGlyLysProAspGlnProVal-64 75-TyrThrLysLeuProGluGluProLysGlyIle-85 92-AspMetGlyAsnValThrAspTrpThrAsnProAsnAlaAspThrGluTrpIleAspAlaLysLys-113 125-GlyMetGlyAlaGluAspAlaLeuProPheGlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGly GlyLysValValGly-153 155-AspAspMetProAsp-159 Hydrophilic Regions - Hopp-Woods 18-ArgGlnAlaGluGluAlaProProProLeu-27 30-GlnIleSerAspArgSerVal-36 46-GluHisAsnGlyProLys-51 58-GlyLysProAspGln-62 77-LysLeuProGluGluProLysGlyIle-85 103-AsnAlaAspThrGluTrpIleAspAlaLysLys-113 127-GlyAlaGluAspAlaLeu-132 135-GlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGlyGlyLys-150 155-AspAspMetProAsp-159 g622 AMPHI Regions - AMPHI 28-LeuProGluAlaValArgAsnLeuAlaArg-37 62-GluGluIleIleArgTrpLeuAlaAsp-70 112-IleLeuGlyGlnIleLysAspAlaValArgAlaAlaGlnGlu-125 132-LysLeuAsnAlaLeuPheGlnLys-139 142-SerValAlaLysGluVal-147 169-GluGlnIlePheProAspIleGlyAsp-177 187-GluMetIleGluLeuValAla-193 214-AlaGlnGluLeuCysAspLys-220 232-AspLeuProAlaIleLeuHis-238 288-AspLeuAsnAspAla-292 297-ValAspAspMetValAsnIleValGlnSerGly-307 324-GluLysValAlaGluPheValArgGlnGln-333 345-LeuArgAspGluGlyGluLys-351 354-LysGlnValLeuGluAsnAlaMetLysGlnLeuAlaLys-366 372-GluValLeuGluArgLeuSerValGlnLeuThr-382 384-LysLeuLeuHisSerProThrGlnThrLeuAsnLysAlaGlyGlu-398 Antigenic Index - Jameson-Wolf 16-SerIleArgGluLysLeuAla-22 30-GluAlaValArgAsnLeuAlaArgSerAsnAlaAla-41 49-ThrCysAsnArgThrGlu-54 57-CysValGlyAspSerGluGluIleIle-65 75-ProIleGluGluIleArgProTyr-82 87-AspMetGlnGluThrValArgHis-94 115-GlnIleLysAspAlaValArgAlaAlaGlnGluGlnGluSerMetGlyAla-131 142-SerValAlaLysGluValArgThrAspThrAlaValGlyGluAsnSerVal-158 174-AspIleGlyAspLeuAsn-179 199-LysAsnP oArgLeu-203 210-ThrLeuAlaArgAlaGlnGluLeuCysAspLysLeuGlyValAsnAlaGlu-226 257-GlyMetValGluArgAlaLeuLysGlnArgGlnSer-268 277-AlaValProArgAspIleGluAlaGluValGlyAspLeuAsnAsp-291 305-GlnSerGlyLysGluAlaArgGlnLysAlaAlaAlaAla-317 321-LeuValSerGluLysValAlaGluPheValArgGlnGlnGlnGlyArgGlnSerVal-339 343-LysAlaLeuArgAspGluGlyGluLysAlaArgLysGlnValLeu-357 368-AlaThrAlaGluGluValLeuGlu-375 381-LeuThrAsnLysLeuLeuHisSerProThrGlnThrLeuAsnLysAlaGlyGluGluAspLysAspLeuVal -404 Hydrophilic Regions - Hopp-Woods 16-SerIleArgGluLysLeuAla-22 30-GluAlaValArgAsnLeuAlaArgSerAsnAlaAla-41 59-GlyAspSerGluGluIleIle-65 75-ProIleGluGluIleArg-80 87-AspMetGlnGluThrValArgHis-94 H " 5-GlhlleLysAspAlaValArgAlaAlaGlnGluGlnGluSerMetGly-130 142-SerValAlaLysGluValArgThrAspThrAlaValGly-154 210-ThrLeuAlaArgAlaGlnGluLeuCysAsp-219 257-GlyMetValGluArgAlaLeuLysGlnArgGlnSer-268 277-AlaValProArgAspIleGluAlaGluValGlyAspLeuAsn-290 305-GlnSerGlyLysGluAlaArgGlnLysAlaAlaAlaAla-317 321-LeuValSerGluLysValAlaGluPheValArg-331 333-GlnGlnGlyArgGlnSer-338 343-LysAlaLeuArgAspGluGlyGluLysAlaArgLysGlnValLeu-357 368-AlaThrAlaGluGluValLeuGlu-375 392-ThrLeuAsnLysAlaGlyGluGluAspLysAspLeuVal-404 g624 AMPHI Regions - AMPHI 17-GlyIleIleGlyIlePheLeuPro-24 45-ArgPheHisArgTrpLeuHis-51 58-ProMetValHisAsn-62 102-SerSerValPheCys-106 Antigenic Index - Jameson-Wolf 41-LysAlaSerProArgPheHisArgTrp-49 51-HisArgHisArgTyrPheGlyProMet-59 63-TrpGluGlnAsnGlyAlaValProArgLysAlaLys-74 114-TrpHisArgProGluSer-119 Hydrophilic Regions - Hopp-Woods 67-GlyAlaValProArgLysAlaLys-74 115-HisArgProGluSer-119 g625 AMPHI Regions - AMPHI 14-ThrArgArgValArgSerTrpLeuAla-22 24-SerSerGlyArgIleIleSerIleAlaAla-33 64-LysMetProProGluMetValTyrArgAla-73 78-MetLysGlyIleTyrSer-83 Antigenic Index - Jameson-Wolf 5-ArgLysMetLysLysMetThrMetCysThrArgArgValArg-18 57-ProPheLysSerProGlnThrLysMetProPro-67 73-AlaSerSerSerArgMetLysGly-80 96-AspAlaProLysThrLysLeuAsnGlyMetArgLysSerAsnValGln-lll Hydrophilic Regions - Hopp-Woods 5-ArgLysMetLysLysMetThrMetCysThrArgArgValArg-18 60-SerProGlnThrLysMetProPro-67 74-SerSerSerArgMetLysGly-80 96-AspAlaProLysThrLysLeuAsnGlyMetArgLysSerAsnValGln-lll g627 AMPHI Regions - AMPHI 21-LeuGlnAsnLeuVal-25 56-IleAlaGluValGlyLysLeuPheLeuGlyIlePheIleThrIlePheProValLeuSerIleLeuLysAlaG lyGluAlaGlyAlaLeuGlyGlyValValSerLeuValHisAspThrAlaGlyHisPro-99 109-GlyIleLeuSerAlaPheLeuAspAsnAla-118 153-PheMetGlyAlaLeuThrTyrIleGlyAsnAlaProAsnPheMetValLys-169 180-ProThrPhePheArgTyr-185 Antigenic Index - Jameson-Wolf 3-GlyLeuTrpLysProGluHisProGlyPhe-12 41-ThrProLysGlnValArgAlaGlyAsnGluPheAsnPhe-53 94-AspThrAlaGlyHis-98 128-AlaGlyGlyAspAla-132 170-AlaIleAlaGluGlnArgGlyValPro-178 Hydrophilic Regions - Hopp-Woods 5-TrpLysProGluHisProGly-ll 43-LysGlnValArgAlaGlyAsn-49 170-AlaIleAlaGluGlnArgGlyVal-177 g628 AMPHI Regions - AMPHI 10-CysGlyProProAsnSerCysValSerIleLeuAlaAlaPhe-23 25-AspGlyThrSerAlaProAlaAla-32 34-HisThrTrpIleLeuArgSer-40 Antigenic Index - Jameson-Wolf 6-LysProAlaGlyCysGlyProProAsnSer-15 23-PheSerAspGlyThrSerAla-29 40-SerValArgArgLeuAsnThrAsnArgProArgLeuLysSerSerAla-55 77-MetAlaAsnGlySerAlaSerThr-84 91-GlyArgValArgSerAlaValHisLysProAspIleArgLeuArgArg-106 115-SerAlaSerGlyThr-119 Hydrophilic Regions - Hopp-Woods 40-ΞerValArgArgLeuAsnThrAsnArgProArgLeuLysSerSerAla-55 91-GlyArgValArgSerAlaValHisLysProAspIleArgLeuArgArg-106 g629 AMPHI Regions - AMPHI 32-ArgTrpSerAspValPheSer-38 48-IleSerArgLeuProArgThrPhe-55 116-ValAlaAlaLeuIleGlyMetLeu-123 145-XxxIlePheGlyGlyValValGluAlaValAlaThrPhe-157 164-MetLeuGlnMetLeuGlyValTrpGlnGlnGlyAsp-175 206-IleLeuGlyLeuGlyGlu-211 253-ValProAsnIleValSerArgLeuMetGlyAspArgLeuArgGlnSer-268 285-IleIleGlyArgMet-289 300-ThrValPheGlyValLeu-305 Antigenic Index - Jameson-Wolf 38-SerLeuSerAspSerGln-43 50-ArgLeuProArgThr-54 77-AsnArgPheValGluProSerMetAlaGlyAlaGlyGln-89 130-ArgArgLeuProProThrAla-136 260-LeuMetGlyAspArgLeuArgGlnSer-268 Hydrophilic Regions - Hopp-Woods 260-LeuMetGlyAspArgLeuArgGln-267 g630 AMPHI Regions - AMPHI 30-ProAspLeuLeuGlnGln-35 81-GlyGlyPheTrpGluValLeuPheAla-89 135-PheGlyGlyThrGlyLysAsnPhe-142 169-AlaValAspGlyTyrSerGlyAlaThrAlaLeuAlaGlnTrp-182 187-AlaAspGlyLeuLysAsnAlaVal-194 203-AspAlaPheIleGlyLysLeuProGlySerIleGlyGluValSer-217 230-PheAlaArgIleAlaSerTrpArgIleIleAlaGlyValMet-243 247-IleAlaMetSerSerLeuIleAsnPhe-255 Antigenic Index - Jameson-Wolf 37-IleAlaHisAspGlyAsnTyr-43 53-MetSerProGluAla-57 90-SerValArgLysHisGluIleAsnGlu-98 133-GluValPheGlyGlyThrGlyLysAsnPheMet-143 157-TyrProAlaAsnLeuSerGlyAspAla-165 186-GlyAlaAspGlyLeuLys-191 209-LeuProGlySerIleGly-214 257-GlySerAspThrLysAla-262 271-GlyThrTrpTrpLysAspAspTyrHisSerLeu-281 Hydrophilic Regions - Hopp-Woods 90-SerValArgLysHisGluIleAsn-97 258-SerAspThrLysAla-262 g638 AMPHI Regions - AMPHI 17-LeuAlaArgPheValAspAsnIle-24 30-IleValAspIleValGlu-35 46-AspIleValGluHisPheGluProPheGlyLys-56 108-ProPheGlyAsnValValAlaAsp-115 118-ArgAlaGlyArgValPro-123 148-ArgIleGlyArgThrMetLysValTyrAlaGluArgIleIle-161 198-GluArgTyrValArgArgValTyrGly-206 212-LeuValProPheAspGlyCysGlyThrValGlyArg-223 242-SerGlnPheAspArgIleAlaArgProGlyAlaGlyLysAsnPheGlyLysValValLeuArgGlyAsnVal -265 304-TrpProAsnLysIleLysHisHis-311 Antigenic Index - Jameson-Wolf 13-GlyLysAsnAlaLeu-17 43-AlaAspGlyAspIle-47 52-GluProPheGlyLys-56 81-ValAspGlyGluThrGlnVal-87 99-AlaGlyIleGlyLysAsnAlaVal-106 113-ValAlaAspAspLeuArgAlaGlyArgValProAsnGlyAsn-126 148-ArgIleGlyArgThrMet-153 169-GlnGlyAlaArgGlyGlyPhe-175 188-HisThrGlyThrGlyAsnGlyGlnValAlaGluArgTyrValArg-202 216-AspGlyCysGlyThrValGlyArgProPheAsnArgAsnArgPheValAsp-232 240-AlaGlySerGlnPheAspArgIleAlaArgProGlyAlaGlyLysAsnPheGly-257 260-ValLeuArgGlyAsnValAspAspGlyCysArgCysArgLeuLysAsnAlaAlaGlyGlyLysTyrGlnHis -283 285-LeuGlnProTyrThrGluArgGlyCys-293 304-TrpProAsnLysIleLysHisHisSerAsn-313 319-AlaLysProProGluThrValArg-326 Hydrophilic Regions - Hopp-Woods 43-AlaAspGlyAspIle-47 81-ValAspGlyGluThrGlnVal-87 113-ValAlaAspAspLeuArgAlaGlyArgValProAsn-124 148-ArgIleGlyArgThrMet-153 195-GlnValAlaGluArgTyrValArg-202 243-GlnPheAspArgIleAlaArgProGlyAlaGlyLysAsnPheGly-257 263-GlyAsnValAspAspGlyCysArgCysArgLeuLysAsnAlaAla-277 288-TyrThrGluArgGlyCys-293 320-LysProProGluThrValArg-326 g639-l AMPHI Regions - AMPHI 95-TyrLysAsnAsnArg-99 137-LeuLysValPheAspAsnIle-143 156-ValAsnTyrSerAspIleHisAspAsnIleIleAsnLysAla-169 268-AlaProValSerArg-272 289-GlnPheProAlaValLeuProGly-296 Antigenic Index - Jameson-Wolf 25-AsnIlePheAspAsnSerPhe-31 41-AlaMetValArgGluAsnLysIleValGly-50 52-AlaThrLeuArgValAsnGluArgGlyAsnGly-62 75-GlyAsnAspIleSerLysGlyArgAspGlyIlePheSerAsnThrSerThrHisAsnThrTyrLysAsnAsnA rgPheSerAsp-102 lll-TyrThrAsnAspSerGluValSerGly-119 135-GluArgLeuLysVal-139 145-ValGlySerArgAspGlyIle-151 159-SerAspIleHisAspAsnIleIleAsnLysAlaGlyLys-171 178-AlaAsnTyrAspLysLeuSerAlaAsnHis-187 202-GluGlyThrSerLeuHisAspAsnSer-210 212-IleAsnAsnGlySerGlnValLysTyrValSer-222 227-AspTrpSerGluGlyGlyHisGlyAsnTyrTrpSerAspAsnSerProPhe-243 245-LeuAsnGlyAspGlyPheGlyAspSerAlaTyrArgProAspGlyIleIle-261 296-GlyGlyValValAspSerLysProLeuMetLysProTyrAlaProLysIleGlnThr-314 317-GlnAlaMetLysAspGluLeuLeuLysGluAlaGluThrArgGlnSerGluArgGlyArgAlaGluAsnGly SerLeuAsn-343 Hydrophilic Regions - Hopp-Woods 41-AlaMetValArgGluAsnLysIleValGly-50 52-AlaThrLeuArgValAsnGluArgGlyAsn-61 77-AspIleSerLysGlyArgAspGlyIle-85 95-TyrLysAsnAsnArgPheSerAsp-102 113-AsnAspSerGluValSerGly-119 135-GluArgLeuLysVal-139 146-GlySerArgAspGlyIle-151 179-AsnTyrAspLysLeuSer-184 253-SerAlaTyrArgProAspGlyIleIle-261 298-ValValAspSerLysProLeuMet-305 317-GlnAlaMetLysAspGluLeuLeuLysGluAlaGluThrArgGlnSerGluArgGlyArgAlaGluAsnGly Ser-341 g640 AMPHI Regions - AMPHI 6-SerIleLeuLysSerIleGly-12 22-SerIleArgArgMetSer-27 47-LeuProAlaTyrAlaGluArgLeuProAspPheLeuAlaLysIleGlnPro-63 72-ArgTyrGlyLysPro-76 109-SerLysProIleAspThrLeuMetAla-117 127-AlaLysLeuValAspHisHis-133 145-ArgValAspLysPheIleAsp-151 155-GlyLeuAsnPhel1eLysAsnProProThr-164 187-IleGlnArgSerTyrLysValIle-194 209-AlaSerAlaSerAsp-213 224-ArgProArgArgMetAlaAsnProAsp-232 255-LeuAspGlnIleAsnLysLeuPheGluLysGly-265 267-LysAlaGlyValAlaAspHisAlaGluGlnGly-277 281-AspThrPheIleAspLeuTyrVal-288 346-MetIleGlnGlyGluAsnSerPhe-353 359-GlnHisGluArgValValGluLeuSerAlaAlaAspAlaProArg-373 Antigenic Index - Jameson-Wolf 24-ArgArgMetSerAlaPheArgAlaArgIle-33 50-TyrAlaGluArgLeuProAspPhe-57 59-AlaLysIleGlnProSerGluIlePheProGlyAlaAspArgTyrGlyLysProGluGlyLysProMetVal- 82 84-ArgValTyrLysGlyAspGluGlnLeu-92 101-AlaValAsnThrArgGlyTyrSerSerLysPro11eAsp-113 128-LysLeuValAspHisHisGlu-134 142-ProGlnSerArgValAspLysPheIleAsp-151 159-IleLysAsnProProThrProSerValAlaProGlyAsp-171 184-AsnAspSerIleGlnArgSerTyrLys-192 196-AsnGlnTyrArgLeuGlySerAspLysAlaLeuGln-207 209-AlaSerAlaSerAspValArgGluAlaAlaProAlaSerGluThrArgProArgArgMetAlaAsnProAsp LysGlnAspIle-236 241-GluLeuLeuLysGlnLysAla-247 257-GlnIleAsnLysLeuPheGluLysGlyGlyLysAlaGlyVal-270 272-AspHisAlaGluGlnGlyAspProAspAspThrPheIle-284 294-ProSerIleGlyLysSerLeuLeuGlyGluAspGlyTrp-306 309-LeuGlnLysArgLeuLysProGlyGln-317 322-ValAlaGlyGluGlyArgTyrSerTrpLysGlySerGlyTyrValArg-337 342-AspArgIleGluMetIleGlnGlyGluAsnSerPheArgPheThrAspAlaGlnHisGluArgValValGlu -365 367-SerAlaAlaAspAlaProArgPheLysGlu-376 382-IleProGluGlyValAla-387 389-AspGlyAlaGluProTrpArg-395 Hydrophilic Regions - Hopp-Woods 24-ArgArgMetSerAlaPheArgAlaArgIle-33 50-TyrAlaGluArgLeuPro-55 68-ProGlyAlaAspArgTyrGlyLysProGluGlyLysProMetVal-82 85-ValTyrLysGlyAspGluGlnLeu-92 128-LysLeuValAspHisHisGlu-134 143-GlnSerArgValAspLysPheIleAsp-151 186-SerIleGlnArgSerTyrLys-192 200-LeuGlySerAspLysAlaLeuGln-207 210-SerAlaSerAspValArgGluAlaAlaProAlaSerGluThrArgProArgArgMetAlaAsnProAspLys GlnAsp-235 241-GluLeuLeuLysGlnLysAla-247 257-GlnIleAsnLysLeuPheGluLysGlyGlyLysAlaGlyVal-270 272-AspHisAlaGluGlnGlyAspProAspAspThrPhe-283 309-LeuGlnLysArgLeuLysProGlyGln-317 324-GlyGluGlyArgTyrSerTrp-330 342-AspArgIleGluMetIleGlnGly-349 351-AsnSerPheArgPheThrAspAlaGlnHisGluArgValValGlu-365 367-SerAlaAlaAspAlaProArgPheLysGlu-376 g642 AMPHI Regions - AMPHI 22-LysSerAlaCysArg-26 28-IleCysProLeuSerAlaIleSerAlaVal-37 63 -SerGlyAspAspPhe-67 139-IleLysHisIleValArgAlaPhe-146 157-AsplleAlaGlyTrpValSerAlaPheLysThrLeuArgAlaGlnGluPheLeuGlnHisLeuArgGlyGly Val-181 184-PheArgGlyGluGly-188 190-AspAspValArgLeu-194 209-AlaAspValAlaValLysAspPheGlyAsnLeuMetAlaAlaLeuAsp-224 241-ValGlnValValLysAspValPheHisAsnAlaValArgHisAlaAspGlnLeuGln-259 293-ValAspGlyValThrAspGlyAla-300 319-GlnValAspAspPheGlyGluPheAlaValPhe-329 348-PheArgGlyValAspVal-353 403-GluLeuLeuGlnArg-407 410-HisGlnArgAlaPheAspAlaGlyThr-418 Antigenic Index - Jameson-Wolf l-MetArgTyrProPro-5 16-CysLeuLeuArgArgProLysSerAlaCysArgArgIleCysPro-30 45-ValGlnGlnGluGlyCysGly-51 58-TyrGluAspLysLysSerGlyAspAspPheAlaAspGluAspPheLeu-73 75-GlyAlaGlyValGly-79 98-GlyAsnGlyGlyLysAlaAspIle-105 126-PheGlyGlyGlyAlaAspGluLeu-133 146-PheLysAsnArgGluGlyAlaAspIleAspGlyAspIle-158 166-LysThrLeuArgAla-170 184-PheArgGlyGluGlyPheAspAspValArgLeu-194 198-MetGlyAspGlyArgAspGlyArgAsnGlyMet-208 230-IleAspGluSerAspIleValAla-237 253-ArgHisAlaAspGlnLeuGlnAlaAlaAlaAspLysAspValLeuGluArgAlaGlnThrGlySerValAla ProGlyGlu-279 281-HisHisGlyGlyCysArg-286 288-PheGly11eAspAlaValAspGlyValThrAspGly-299 313-CysPheGlyAspGluGlnGlnValAspAspPheGly-324 332-PheGlyGlyAsnGluGluGluValAla-340 369-CysAsnArgArgAlaGlyGlyPhe-376 412-ArgAlaPheAspAlaGlyThrGlnArgAsnGly-422 425-ValMetProArgAsnPro-430 Hydrophilic Regions - Hopp-Woods 16-CysLeuLeuArgArgProLysSerAlaCysArgArgIleCys-29 58-TyrGluAspLysLysSerGlyAspAspPheAlaAspGluAspPheLeu-73 99-AsnGlyGlyLysAlaAspIle-105 129-GlyAlaAspGluLeu-133 146-PheLysAsnArgGluGlyAlaAspIleAspGlyAspIle-158 166-LysThrLeuArgAla-170 187-GluGlyPheAspAspValArgLeu-194 199-GlyAspGlyArgAspGlyArgAsnGlyMet-208 230-IleAspGluSerAspIleValAla-237 253-ArgHisAlaAspGlnLeuGlnAlaAlaAlaAspLysAspValLeuGluArgAlaGlnThr-272 292-AlaValAspGlyValThrAspGly-299 313-CysPheGlyAspGluGlnGlnValAspAspPheGly-324 334-GlyAsnGluGluGluValAla-340 369-CysAsnArgArgAlaGly-374 417-GlyThrGlnArgAsnGly-422 g644 AMPHI Regions - AMPHI 26-GlyArgArgPheAspArgPro-32 55-MetAspThrAlaAlaPheLeuLysHisIleGluSerAlaPheProArgIlePheSerAspGlyIleAspLeuM etArgTyrLeu-82 lll-GlnPheGluIleGlnGluValLeuArgIleAlaGly-122 141-GlnProLeuGlnGluPheGlyGly-148 181-ArgGluMetGlnSerCysTyrGluTyr-189 202-TyrTrpGlnGlyAsn-206 224-LeuAlaLysValIleAspLeuLeu-231 267-ValMetLysLeuSerArg-272 278-LeuArgAlaPheGlnAsn-283 295-MetThrHisGlyIleMetGluTyrIleLeuAspAsnLeuAsnArgTyrValArgAsn-313 333-GluIleLeuTyrArgTyrValCysHis-341 343-ValSerProValAlaProValAlaHis-351 356-AlaAsnIleValLysThrLeuAla-363 372-GlnMetLeuGlnLys-376 399-PheThrIlePheGluGlyProAsn-406 408-MetLeuTyrAlaGluIleTyrAspGlnPheValArgAla-420 456-LeuProGluAspIleArgSerPhe-463 481-GlyLysIleIleAlaArgLeu-487 Antigenic Index - Jameson-Wolf 1-MetProSerGluArgProAlaAspCysCys-lO 22-ThrLeuAsnCysGlyArgArgPheAspArgProProIleAsnGlyAsnArgGlnArgLysProMetIleHisT hrGluProSerAlaGlnProSerThrMetAsp-56 70-ArgIlePheSerAspGlyIleAspLeu-78 82-LeuProGluAspLysTrpLeu-88 100-LeuAspLysLysHisGlyGlyArgLysGlySerGln-111 160-PheLysGlyGluSerArgArgLeuGlyValThrGluProGluThrSerGly-176 178-AlaIleAlaArgGluMetGlnSerCysTyrGluTyrThrAspGluGlnThr-194 202-TyrTrpGlnGlyAsnSerGlnSerAspPhe-211 216-AlaLysGluArgLysAsnGlyLysLeuAlaLys-226 235-LysThrTyrIleArg-239 241-GluThrLeuAlaSerGluGlyLeuArg-249 254-AlaValAsnArgIleAspAlaGluMet-262 269-LysLeuSerArgGlyAspAlaAlaGly-277 306-AsnLeuAsnArgTyrValArgAsnAspIleArgPheValAspTyrGluArgArgGluIleGlnArgArgHis GlnVal-331 381-LysGlyPheGluArgGlyHisProAlaGly-390 403-GluGlyProAsnAspMetLeu-409 420-AlaThrAlaGluGluLysGluAlaGlyIleLysLeuAspLysAsnGlnThr-436 441-ValGlnThrAspValArg-446 449-AlaValAlaArgAspTyrAlaLeu-456 458-GluAspIleArgSerPheLeu-464 492-GlnGluGluHisGluAspThrThr-499 505-Aspl1eArgLysAspIleLeuAspCysArgTyrCysGly-517 Hydrophilic Regions - Hopp-Woods l-MetProSerGluArgProAlaAsp-8 25-CysGlyArgArgPheAspArgProProIleAsnGlyAsnArgGlnArgLysProMetIle-44 72-PheSerAspGlyIleAsp-77 82-LeuProGluAspLysTrpLeu-88 100-LeuAspLysLysHisGlyGlyArgLysGlySerGln-lll 160-PheLysGlyGluSerArgArgLeuGlyValThrGluProGluThrSerGly-176 178-AlaIleAlaArgGluMetGlnSer-185 188-GluTyrThrAspGluGlnThr-194 216-AlaLysGluArgLysAsnGlyLysLeuAlaLys-226 254-AlaValAsnArgIleAspAlaGluMet-262 269-LysLeuSerArgGlyAspAlaAlaGly-277 306-AsnLeuAsnArgTyrValArgAsnAspIleArgPheValAspTyrGluArgArgGluIleGlnArgArgHis GlnVal-331 381-LysGlyPheGluArgGlyHisPro-388 420-AlaThrAlaGluGluLysGluAlaGlyIleLysLeuAspLysAsnGlnThr-436 441-ValGlnThrAspValArg-446 458-GluAspIleArgSerPheLeu-464 492-GlnGluGluHisGluAspThrThr-499 505-Aspl1eArgLysAspIleLeuAsp-512 g645 AMPHI Regions - AMPHI 87-ArgThrLeuProSerLeuAsnGlyLeuThrLys-97 149-ArgThrProLysArgCysSerSerSerIle-158 162-ProLysPheLeuAsnPheMetSerSerCysThrAsnLeuCys-175 211-SerAlaLysArgSer-215 250-SerValLeuProLysProThrSerProHisThrSerArg-262 Antigenic Index - Jameson-Wolf 24-AsnLeuCysCysLysLysSerArgMetThrCysSerSerSerArgSerArgSerCysProCys-44 47-ProIleArgAlaSerGlySerArgValSerSerArgSerArgIle-61 68-SerLeuCysArgLysAsnThrCysProProArgLeuSerSerArgAsnThrAlaSerArgThrLeuProSer- 91 99-PheThrAlaArgArgArgLeuGly-106 HO-IleSerGluLysSerArgArgProSerSerAlaMetLeuArg-123 137-ThrLeuAlaArgArgArgLeuSerCysSerPheCysArgThrProLysArgCysSerSer-156 158-IleIleAsnLysProLysPheLeuAsn-166 168-MetSerSerCysThrAsn-173 199-LeuLysArgGluArgLeuAla-205 208-ThrGlyLysSerAlaLysArgSerAlaLys-217 222-CysSerThrArgSerValValGlyAla-230 243-AsnAlaAlaArgArgAlaThr-249 251-ValLeuProLysProThrSerProHisThrSerArg-262 Hydrophilic Regions - Hopp-Woods 26-CysCysLysLysSerArgMetThrCysSerSerSerArgSerArgSerCysPro-43 48-IleArgAlaSerGlySerArgValSerSerArgSerArgIle-61 69-LeuCysArgLysAsnThrCysProProArgLeuSerSerArgAsnThrAlaSerArgThr-88 99-PheThrAlaArgArgArgLeuGly-106 HO-IleSerGluLysSerArgArgProSer-118 137-ThrLeuAlaArgArgArgLeuSer-144 149-ArgThrProLysArgCysSer-155 158-IleIleAsnLysProLys-163 199-LeuLysArgGluArgLeuAla-205 210-LysSerAlaLysArgSerAlaLys-217 243-AsnAlaAlaArgArgAlaThr-249 g647 AMPHI Regions - AMPHI 38-GlyLysValCysArgCysPheGluGlnVal-47 69-ThrValPheArgGlnIleValGlyValVal-78 Antigenic Index - Jameson-Wolf 26-GlyLeuValLysGluArgAlaArg-33 39-LysVa1CysArgCysPhe-44 54-GlyThrValGlyGlnThrGluArgGlyThr-63 78-ValAspAspThrAspAlaGluArgThrAlaValHisSerArgGlyThrArgGlyPhe-96 Hydrophilic Regions - Hopp-Woods 26-GlyLeuValLysGluArgAlaArg-33 40-ValCysArgCysPhe-44 56-ValGlyGlnThrGluArgGlyThr-63 78-ValAspAspThrAspAlaGluArgThrAlaValHisSerArgGlyThrArgGly-95 g648 AMPHI Regions - AMPHI 7-ArgIleGluArgAlaValArg-13 15-AlaValIleAspValLeuAsn-21 94-AlaValAspLeuHisAlaIleIleLysLeuAlaAspThr-106 127-GlnGlyValGluGlnGly-132 148-ArgLeuLysHisLeuLysGluGlyAsnAla-157 182-AlaArgAlaLeuGlyAsnValPheHis-190 194-GlySerGlyIleAspGlyIleGlnThrIleValAlaPheAsnGlnHisThr-210 Antigenic Index - Jameson-Wolf l-MetAsnArgArgAsnAlaArgIleGluArgAlaValArg-13 24-AlaProGlyProGly-28 30-LeuLeuHisGlnArgGlyLysGlnValGlyΞerArgAsnAspThrLeuAla-46 65-GlyLysLysArgPheValGlnProArgAsnLeuValGlyArgLysGlnArgAsn-82 123-PheAsnMetProGlnGlyValGluGlnGlyCysArg-134 141-LeuArgThrArgPheAspArgArgLeuLysHisLeuLysGluGlyAsnAla-157 170-ValGlnProAlaAspThrSerGlyIleAspAlaAspAlaArgAla-184 191-AsnArgAlaGlySerGlyIleAspGly-199 Hydrophilic Regions - Hopp-Woods l-MetAsnArgArgAsnAlaArgIleGluArgAlaValArg-13 33-GlnArgGlyLysGlnValGlySerArgAsnAspThr-44 65-GlyLysLysArgPheValGln-71 74-AsnLeuValGlyArgLysGlnArgAsn-82 127-GlnGlyValGluGlnGlyCysArg-134 141-LeuArgThrArgPheAspArgArgLeuLysHisLeuLysGluGlyAsnAla-157 172-ProAlaAspThrSerGlyIleAspAlaAspAlaArgAla-184 g649 AMPHI Regions - AMPHI 6-LeuSerAlaIleLeuGlyLeuVal-13 24-ProAlaHisArgHisThrLysHisIleSerLysAla-35 57-SerGlnGlyAsnVal-61 63-GluLeuArgGluAsnLys-68 71-ArgLysAlaPheArgThrLeuPro-78 Antigenic Index - Jameson-Wolf 20-GlyThrSerGluProAlaHisArgHisThrLysHisIleSerLysAlaAsnLys-37 40-LeuHisProGluCysArgLysTyrLeuGluArgArgAlaAla-53 56-ArgSerGlnGlyAsnValGlnGluLeuArgGluAsnLysLysAlaArgLysAlaPheArg-75 80-AlaGluGlnLysIleGlnCys-86 92-AlaPheAspAspPheAspGlyGlyArgPheArgArg-103 Hydrophilic Regions - Hopp-Woods 20-GlyThrSerGluProAlaHisArgHisThrLysHisIleSerLysAlaAsnLys-37 42-ProGluCysArgLysTyrLeuGluArgArgAlaAla-53 59-GlyAsnValGlnGluLeuArgGluAsnLysLysAlaArgLysAlaPheArg-75 80-AlaGluGlnLysIleGlnCys-86 92-AlaPheAspAspPheAspGlyGlyArgPheArgArg-103 g650 AMPHI Regions - AMPHI 15-SerValCysProGly-19 57-LeuTrpAspGluLeuArgGlnGly-64 72-ProGluLeuValArgArgHisGlu-79 89-PheAspArgValValAsn-94 137-SerGlyLeuTrpGln-141 173-AsnTyrLeuGlnTyrLeuTyrGlyLeuPheGlyAspTrpPro-186 198-AsnValGlyArgAlaValAsnArgAlaArg-207 218-LeuArgMetProAsnGluThr-224 260-ValGluProGlyArgProLeu-266 269-GluAlaIleAlaArgLeuAlaGlyIleThrGlnSer-280 314-SerAsnTyrLeuAsnAlaAlaProAsp-322 341-IleSerThrAlaThrGlyMet-347 349-11eAlaAspI1eLysArgLeuAsnAsnLeu-358 433-ValArgThrGlyThrArgSer-439 Antigenic Index - Jameson-Wolf l-MetSerLysLeuLys-5 24-GlnAsnThrSerSerHis-29 38-LeuAsnSerSerIleLeuAspLeuProProThrLysGlnTyrPhe-52 54-SerGlySerLeuTrpAspGluLeuArgGlnGlyPheArgMetGlyGluValAsnProGluLeuValArgArgH isGluSerLysPheIleAla-84 87-SerTyrPheAspArgValValAsnArgSerArgPro-98 105-AsnGluValLysLysArgAsnMetProAla-114 128-ThrLysAlaLysSerHisValGlyAlaSerGly-138 145-AlaThrGlyArgHisTyrGlyLeuGluLysThrProValTyrAspGlyArgHisAspVal-164 192-TyrAsnTrpGlyGluGlyAsnValGlyArgAlaValAsnArgAlaArgAspGlnGlyLeuGluProThrTyr GluAsnLeuArgMetProAsnGluThrArgAsnTyrVal-228 247-AsnIleSerAspIleAspAsnLysProTyr-256 259-AlaValGluProGlyArgProLeuAspAsnGluAlaIleAla-272 294-PheIleProLysAsnLysArgLysLeu-302 318-AsnAlaAlaProAspSer-323 332-ProAlaAlaLysThrSerLeuSerAspIleSerThr-343 350-AlaAspIleLysArgLeuAsnAsnLeuAsnGly-360 370-LeuValAlaLysAsnGlyLysThrLeu-378 388-IleAspIleAspAsnThrProAspThrTyrArgSerAsnMetProAla-403 431-GluThrValArgThrGlyThrArgSerProCysProHisTyrArgThrArgProCysAspSerArgSerAla ThrSerAsnArgLysThrAspCysHisAla-464 Hydrophilic Regions - Hopp-Woods l-MetSerLysLeuLys-5 59-AspGluLeuArgGlnGlyPheArgMetGlyGluValAsnProGluLeuValArgArgHisGluSerLysPheI leAla-84 92-ValValAsnArgSerArgPro-98 105-AsnGluValLysLysArgAsnMetProAla-114 128-ThrLysAlaLysSerHisVal-134 150-TyrGlyLeuGluLysThrProValTyrAspGlyArgHisAspVal-164 202-AlaValAsnArgAlaArgAspGlnGlyLeu-211 213-ProThrTyrGluAsnLeuArgMetProAsnGluThrArgAsnTyrVal-228 249-SerAspIleAspAsn-253 261-GluProGlyArgProLeuAspAsnGluAlaIleAla-272 296-ProLysAsnLysArgLysLeu-302 334-AlaLysThrSerLeu-338 350- laAspI1eLysArgLeuAsn-356 373-LysAsnGlyLysThr-377 389-AspIleAspAsnThrProAspThrTyrArg-398 431-GluThrValArgThrGlyThrArgSerPro-440 444-TyrArgThrArgProCysAspSerArgSerAlaThrSerAsnArgLysThrAspCys-462 g652-l AMPHI Regions - AMPHI 6-AspIlePheAlaArg-10 52-ArgAspGlyAspLys-56 62-LysGlyValLeuLysAlaValGluHisValAsnAsnGlnIleAlaGlnAla-78 130-LeuTyrArgTyrLeuGlyGlyAlaGlyPro-139 149-ValIleAsnGlyGly-153 173-LysSerPheArgGluAlaLeuArgCys-181 184-GluIlePheHisAlaLeuLysLys-191 266-AlaGluPheAlaGluTyrLeuGluGlyLeuValAsn-277 299-LeuThrGluLysLeu-303 323-AlaGluGlyIleGluLysGlyVal-330 338-ValAsnGlnIleGlyThrLeuSerGluThrLeuLysAlaValAspLeuAlaLysCysAsnArgTyrAlaSer -361 377-AspLeuAlaValAla-381 391-SerLeuSerArgSerAspArgMetAlaLysTyrAsnGlnLeuLeuArgIleGluGlu-409 Antigenic Index - Jameson-WoIf H-GluIleLeuAspSerArgGlyAsnProThrValGlu-22 36-AlaValProSerGlyAlaSerThrGlyGlnLysGluAlaLeuGluLeuArgAspGlyAspLysSerArgTyrS erGlyLysGlyValLeuLysAlaValGluHisValAsn-72 83-AspAlaAsnGluGlnSerTyr-89 97-LeuAspGlyThrGluAsnLysGlyAsnLeuGly-107 121-AlaAlaAlaGluAspSerGlyLeuPro-129 135-GlyGlyAlaGlyProMet-140 151-AsnGlyGlyGluHisAlaAsnAsnSer-159 173-LysSerPheArgGluAlaLeuArgCysGlyAla-183 190-LysLysLeuCysAspSerLysGlyPheProThrThrValGlyAspGluGlyGlyPhe-208 211-AsnLeuAsnSerHisLysGluAlaLeu-219 243-CysAlaSerSerGluPheTyrLysAspGlyLysTyrHisLeuGluAlaGluGlyArgSerTyrThrAsn-2. 5 283-SerIleGluAspGlyMetAspGluAsnAspTrpGluGly-295 299-LeuThrGluLysLeuGlyLysLysValGlnLeuValGlyAspAspLeu-314 318-AsnProLysIleLeuAlaGluGlyIleGluLysGlyVal-330 352-AspLeuAlaLysCysAsnArgTyr-359 363-MetSerHisArgSerGlyGluThrGluAspSerThrIle-375 388-LysThrGlySerLeuSerArgSerAspArgMetAlaLys-400 405-LeuArgIleGluGluGluLeuAlaGlu-413 Hydrophilic Regions - Hopp-Woods ll-GluIleLeuAspSerArgGlyAsnProThrValGlu-22 43-ThrGlyGlnLysGluAlaLeuGluLeuArgAspGlyAspLysSerArgTyrSerGly-61 63-GlyValLeuLysAlaValGlu-69 97-LeuAspGlyThrGluAsnLysGlyAsnLeu-106 121-AlaAlaAlaGluAspSerGly-127 153-GlyGluHisAlaAsn-157 173-LysSerPheArgGluAlaLeuArgCysGlyAla-183 190-LysLysLeuCysAspSerLysGly-197 202-ValGlyAspGluGlyGlyPhe-208 213-AsnSerHisLysGluAlaLeu-219 247-GluPheTyrLysAspGlyLysTyrHisLeuGluAlaGluGlyArgSerTyrThr-264 283-SerIleGluAspGlyMetAspGluAsnAspTrpGluGly-295 299-LeuThrGluLysLeuGlyLysLysValGlnLeuValGly-311 321-IleLeuAlaGluGlyIleGluLysGlyVal-330 352-AspLeuAlaLysCysAsnArg-358 364-SerHisArgSerGlyGluThrGluAspSerThrIle-375 391-SerLeuSerArgSerAspArgMetAlaLys-400 405-LeuArgIleGluGluGluLeuAlaGlu-413 g653 AMPHI Regions - AMPHI 60-ThrMetArgLysProArgLeuThr-67 75-AlaLeuIlePheThrCysPheAla-82 96-ThrAlaLeuAlaAlaIleThrCysIle-104 lll-LeuGlyLysMetGluGluPheSer-118 Antigenic Index - Jameson-Wolf 4-GluProMetArgMetProGlu-10 14-GlyPheSerGlySer-18 45-GlyCysArgSerThrArgLysThr-52 56-ValArgProGluThrMetArgLysProArgLeuThrAsnSerSerAla-71 86-AsnSerGlyCysAsnAla-91 103-CysIleAsnGlyProProCysArgLeuGlyLysMetGluGlu-116 125-SerArgHisLysIleThrProProArgGlyProArgArgVal-138 145-ThrLysSerGlnAsnGlyThrGly-152 156-SerProProAlaThrSerProAla-163 Hydrophilic Regions - Hopp-Woods 4-GluProMetArgMetProGlu-10 47-ArgSerThrArgLysThr-52 57-ArgProGluThrMetArgLysProArgLeuThrAsn-68 107-ProProCysArgLeuGlyLysMetGluGlu-116 126-ArgHisLysIleThrProProArgGlyProArg-136 g656 AMPHI Regions - AMPHI 6-GlySerIleSerSerMetIleSerIleAlaArgThrPheGlyAlaProGlu-22 42-LysGlnProSerThr-46 92-LeuAlaSerLeuAsnLysSerCys-99 Antigenic Index - Jameson-Wolf 4-PheSerGlySerIle-8 19-GlyAlaProGluSerValProAlaGlyLysValAlaAla-31 40-SerPheLysGlnProSerThrLeuGlu-48 74-ArgProThrSerLeuArgProLysSerIle-83 94-SerLeuAsnLysSerCysSerLeuAlaArgSerSerAlaGlyValLeuProArgArgArgValProAla-116 120-ThrMetThrSerSerArgSerArgArgThrArgIleSerGlyGluGluProThrMetTrpLysSerProLys Ser-144 Hydrophilic Regions - Hopp-Woods 76-ThrSerLeuArgProLysSer-82 99-CysSerLeuAlaArgSerSer-105 109-LeuProArgArgArgValProAla-116 121-MetThrSerSerArgSerArgArgThrArgIleSerGlyGluGluProThrMet-138 140-LysSerProLysSer-144 g657 AMPHI Regions - AMPHI 20-LeuGlyArgMetPheAla-25 65-AspGluLeuAlaLysCysAlaAla-72 83-AspAlaMetArgSerLeuAlaLysHisThrAsn-93 128-CysLysAlaGluAspIleThrGluAlaSer-137 139-GlnPheLeuProGlyIleLeuLysThr-147 161-LysThrLeuAspGluLeuLysAlaAla-169 178-CysValLeuGluLysMetValAsp-185 205-PheAspProAlaGluAsnIle-211 232-GlnGlnAlaArgGlnThrAlaGlnArgLeuAlaAspGluLeuAspTyrValGlyValLeu-251 Antigenic Index - Jameson-Wolf 37-ValLeuAspProAspProAsnAlaPro-45 57-ProPheAspAspArgAlaAlaLeuAspGluLeuAlaLys-69 75-ThrGluPheGluAsnValAsnAlaAspAlaMetArgSerLeuAlaLysHisThrAsnValSerProSerGlyA spCysVal-101 104-AlaGlnAsnArgIleGlnGluLysAlaTrpIle-114 128-CysLysAlaGluAspIleThrGluAla-136 150-LeuGlyTyrAspGlyLysGlyGlnIleArgValLysThrLeuAspGluLeuLysAlaAlaPhe-170 182-LysMetValAspLeuArgGlyGluIle-190 196-ArgLeuAsnAspGluAsnValGln-203 205-PheAspProAlaGluAsnIleHisGluAsnGly-215 230-ValGlnGlnGlnAlaArgGlnThrAlaGlnArgLeuAlaAspGluLeuAsp-246 268-GluThrAlaProArgThrHisAsnSerGlyHisHis-279 288-GlnPheGlnGlnGln-292 300-ProProAlaAspThrLysLeuLeuSer-308 319-ValTrpGlnGluAspGlyGlyGluProAspTrp-329 332-LeuGlnSerArgProAsnAla-338 344-GlyLysLysThrAlaGlnLysGlyArgLysMetGly-355 361-ThrThrAspSerAspThrAlaPheGlnGluAlaLysLysLeuHis-375 Hydrophilic Regions - Hopp-Woods 37-ValLeuAspProAspProAsnAlaPro-45 57-ProPheAspAspArgAlaAlaLeuAspGluLeuAlaLys-69 75-ThrGluPheGluAsnValAsn-81 83-AspAlaMetArgSerLeuAlaLys-90 128-CysLysAlaGluAspIleThrGluAla-136 152-TyrAspGlyLysGlyGlnIleArgValLysThrLeuAspGluLeuLysAlaAlaPhe-170 182-LysMetValAspLeuArgGlyGluIle-190 196-ArgLeuAsnAspGluAsnValGln-203 206-AspProAlaGluAsnIleHis-212 230-ValGlnGlnGlnAlaArgGlnThrAlaGlnArgLeuAlaAspGluLeuAsp-246 269-ThrAlaProArgThrHisAsn-275 301-ProAlaAspThrLysLeu-306 320-TrpGlnGluAspGlyGlyGluProAsp-328 344-GlyLysLysThrAlaGlnLysGlyArgLysMetGly-355 362-ThrAspSerAspThrAlaPheGlnGluAlaLysLysLeuHis-375 g658 AMPHI Regions - AMPHI 28-ArgGlnTyrAlaAspIleIleGlnPheValArgGlnAlaLeuArgArgLeuProArgLeuLeuLeu-49 68-ValAspValPheGlyGlyValGluGly-76 93-AlaGlnValHisHisPhePheGlnAsnAlaIleHisAla-105 139-GlnLysLeuArgAlaCysPheSerAsnValPheGly-150 155-LeuIleArgArgGlyLeuGln-161 Antigenic Index - Jameson-Wolf 6-ValArgAlaArgGlyGlyPheIleAsp-14 21-AlaAspAsnLysHisPhe-26 40-AlaLeuArgArgLeuPro-45 53-ThrGlnProArgGlyAspAspGlyIleSerGlnAspAlaVal-66 86-TyrAspHisGlyAsn-90 107-ValPheGlyLysArgGlyPheGluPhe-115 130-GlnArgSerArgPheGlnAspAlaGlyGlnLysLeuArgAla-143 154-ArgLeuIleArgArgGlyLeuGln-161 193-ArgAlaHisArgValGly-198 202-PheLysPheGlyArgAsnArgArgAla-210 216-GlnArgGlyProValValLysArgArgAlaGln-226 230-GlyLysPheArgArgArgArgIleArgValGlyIleGluAsnGly-244 251-PheSerGlyAsnGlyLysHisSerAla-259 Hydrophilic Regions - Hopp-Woods 6-ValArgAlaArgGlyGlyPheIle-13 21-AlaAspAsnLysHisPhe-26 40-AlaLeuArgArgLeuPro-45 53-ThrGlnProArgGlyAspAspGlyIleSer-62 130-GlrιArgSerArgPheGlnAspAlaGlyGlnLysLeuArgAla-143 154-ArgLeuIleArgArgGlyLeu-160 193-ArgAlaHisArgValGly-198 205-GlyArgAsnArgArgAla-210 210-ProValValLysArgArgAlaGln-226 230-GlyLysPheArgArgArgArgIleArgValGlyIle-241 253-GlyAsnGlyLysHisSerAla-259 g661 AMPHI Regions - AMPHI 19-GlyIleAlaAspLysProPheArgArgLeuCysArgAlaPheGlyAla-34 48-LeuArgAsnThrGlyLysThrLeu-55 76-ProGluGlnMetAlaAsp-81 122-AlaAlaIleLeuGluAlaValValLys-130 152-ProAlaValAlaLysIleAlaGlu-159 222-HisAspArgAlaArg-226 237-PheGluAlaLeuCysArg-242 246-PheThrAlaCysLeuGluPhe-252 Antigenic Index - Jameson-Wolf 20-IleAlaAspLysProPheArgArgLeuCysArg-30 45-AspProThrLeuArgAsnThrGlyLysThrLeuHisArgSerAspPheAlaAspGluGlyGly-65 72-AlaGlySerAspProGluGlnMetAlaAspAlaAlaArg-84 97-AsnMetGlyCysProAlaLysLysValCys-106 115-MetGlnAspGluProLeu-120 143-GlyTrpHisAspAspAspGlnAsnLeu-151 156-LysIleAlaGluAspCysGly-162 169-ProArgAlaArgAla-173 175-AlaAsnValGlnArgArgGlyAlaLeuArgThrHisArgArgAspGlnLysProSerGluHisProGlyLeu GlyGlnArgArgHisHisPheAlaAlaLysSerArgArgArgProGlnThrAsnArgArgArgArgHisHisAspA rgAlaArgArgAlaArgGln-230 241-CysArgThrArgArgPhe-246 253-GlyArgMetGlnSerArgHisPheGluProHisProArgHisAlaArg-268 271-TrpXxxAspArgArgCysAlaHisArgThrGlnThrHisArgLeuValHisArgArgAsnAlaArgArgArg ThrGlyAlaAla-298 Hydrophilic Regions - Hopp-Woods 20-IleAlaAspLysProPheArgArgLeuCysArg-30 46-ProThrLeuArgAsnThrGlyLysThrLeuHisArgSerAspPheAlaAspGluGlyGly-65 73-GlySerAspProGluGlnMetAlaAspAlaAlaArg-84 100-CysProAlaLysLysValCys-106 115-MetGlnAspGluProLeu-120 144-TrpHisAspAspAspGlnAsn-150 156-LysIleAlaGluAspCysGly-162 169-ProArgAlaArgAla-173 175-AlaAsnValGlnArgArgGlyAlaLeuArgThrHisArgArgAspGlnLysProSerGluHisProGlyLeu GlyGlnArgArgHisHisPhe-205 207-AlaLysSerArgArgArgProGlnThrAsnArgArgArgArgHisHisAspArgAlaArgArgAlaArgGln -230 241-CysArgThrArgArgPhe-246 253-GlyArgMetGlnSerArgHisPheGluProHisProArgHisAla-267 271-TrpXxxAspArgArgCysAlaHisArgThrGlnThr-282 285-LeuValHisArgArgAsnAlaArgArgArgThrGlyAla-297 g663 AMPHI Regions - AMPHI 19-ProPheAlaLeuLeuHisLys11eAlaGlyLeuI1eGlySerLeuAlaTyr-35 66-LysGlnHisPheLysHisMetAlaLysLeu-75 86-SerAlaLysCysLeuLysSerLeuValArg-95 168-GluGlyLeuArgAlaLeuValLysGlnPheArgLys-179 209-ThrIleThrGlyLeuSerArgIleAlaAlaLeuAlaAsn-221 243-ProAlaTrpLysSer-247 258-GlnArgMetAsnArgPheIleGluGluArgValArgGluHis-271 Antigenic Index - Jameson-Wolf 38-ValLysProArgArgArgIleGlyGlu-46 54-ProGluTrpAspGluGluLysArgLysThrValLeu-65 87-AlaLysCysLeuLysSer-92 94-ValArgTyrArgAsnLysHisTyrLeuAsp-103 105-AlaLeuAlaAlaGlyGluLys-lll 139-TyrSerHisGlnLysAsnLysIleLeuAsp-148 150-GlnIleLeuLysGlyArgAsnArgTyr-158 166-ArgThrGluGlyLeuArgAlaLeu-173 175-LysGlnPheArgLysSerSerAla-182 188-ProAspGlnAspPheGlyArgAsnAsnSer-197 229-ProValArgGluAlaAspAsήThrVal-237 243-ProAlaTrpLysSerPheProSerGluAspAlaGlnAlaAspAlaGlnArgMetAsnArgPheIleGluGlu ArgValArgGluHisProGlu-273 280-LysArgPheLysThrArgProGluGlySerProAspPheTyr-293 Hydrophilic Regions - Hopp-Woods 39-LysProArgArgArgIleGlyGlu-46 54-ProGluTrpAspGluGluLysArgLysThrValLeu-65 88-LysCysLeuLysSer-92 94-ValArgTyrArgAsn-98 105-AlaLeuAlaAlaGlyGluLys-lll 142-GlnLysAsnLysIleLeuAsp-148 150-GlnIleLeuLysGlyArgAsnArgTyr-158 166-ArgThrGluGlyLeuArgAlaLeu-173 176-GlnPheArgLysSerSer-181 190-GlnAspPheGlyArg-194 229-ProValArgGluAlaAspAsn-235 248-PheProSerGluAspAlaGlnAlaAspAlaGlnArgMetAsnArgPheIleGluGluArgValArgGluHis ProGlu-273 280-LysArgPheLysThrArgProGluGlySerPro-290 g664 AMPHI Regions - AMPHI 28-AlaHisArgMetGly-32 47-AlaAspValLeuAspAlaAlaHisGlyAlaAlaGly-58 90-ProValValGluIle-94 158-LeuHisArgValPheSerThrIleProArg-167 Antigenic Index - Jameson-Wolf 26-AspGlyAlaHisArgMetGlyGlyArgAla-35 73 -PheLeuGlnArgLysLeuGluPro-80 113-AlaValGlyGluAspGluLeuGlyVal-121 138-TyrGlyAspAspHisGluAsn-144 163-SerThrIleProArgGlnSerArgProTrp-172 175-ProLeuArgTrpCysLysThrArgPhe-183 Hydrophilic Regions - Hopp-Woods 27-GlyAlaHisArgMetGlyGly-33 74-LeuGlnArgLysLeuGluPro-80 113-AlaValGlyGluAspGluLeuGlyVal-121 138-TyrGlyAspAspHisGluAsn-144 166-ProArgGlnSerArg-170 g665-l AMPHI Regions - AMPHI 6-ArgTyrLeuLysAspTyrGln-12 115-GlnCysGluProGluGlyPheArgLysIleThr-125 132-AspValMetSerLysPheThrThrThr-140 167-ArgHisTrpValLysTrpGluAspProPhe-176 225-SerLeuLysAsnAlaMetLys-231 286-GlyIleGluSerValVal-291 294-GluTyrPheHisAsnTrpThr-300 307-ArgAspTrpPheGlnLeuSerLeu-314 329-AspArgAlaGlyArgAlaValArgArgIleGluAsnIleArgLeuLeuArgGln-346 358-HisProValArgProValSerTyrGluGluMetAsnAsnPheTyrThr-373 380-GlyAlaGluValValArgMetTyrHisThrLeu-390 396-PheGlnLysGlyMetLys-401 517-GluGlyValThrGluAlaValValProSerLeuLeuArgGlyPheSerAlaProVal-535 559-CysTrpGluAlaAla-563 575-LeuAlaAlaLeuSerAspGlyIle-582 589-LysLeuLeuAlaAlaValGlu-595 603-LeuAspAsnAlaPheLysAlaLeu-610 622-AspGlyThrGluAsnIleAspProLeu-630 642-ThrLeuAlaValArg-646 648-LeuProLyεTrpHisGluLeuAspArg-656 674-AspTrpArgThrLeuArgAεnValCysArgAla-684 696-ThrValAlaGluLysTyrGlyGluMetAlaGlnAsnMet-708 712-TrpGlyIleLeuSer-716 730-LeuAlaGlnPheAlaAspLysPheSer-738 758-AspThrLeuGlnGlnValGlnThrAla-766 782-SerLeuIleGlySerPheSerArgAsnVal-791 822-ArgLeuValGlnAlaPheAsnLeuCysAsnLysLeu-833 Antigenic Index - Jameson-Wolf l-MetSerLysThrValArgTyrLeuLysAspTyrGlnThrProAla-15 32-ThrValValLysSerArgLeuThrValGluProGlnArgAlaGlyGlu-47 49-LeuValLeuAspGlySerAla-55 79-AlaAspValProSerGluArgPheThrVal-88 90-ValGluThrGluIleLeuProAlaGluAsnLysSerLeu-102 115-GlnCysGluProGluGlyPheArgLys-123 128-IleAspArgProAspValMetSer-135 142-ValAlaAspLysLysArgTyrPro-149 153-SerAsnGlyAsnLysIleAspGlyGlyGluPheSerAspGlyArgHisTrpValLysTrpGluAspProPhe AlaLysProSer-180 191-AlaValThrGluAspArgPheThrThrMetSerGlyArgAsnValLysIle-207 211-ThrThrGluAlaAspLysProLysVal-219 230-MetLysTrpAspGluThrArgPhe-237 255-AsnMetGlyAlaMetGluAsnLysGlyLeu-264 275-AspSerArgThrAlaThrAspThrAspPheGluGlyIleGlu-288 295-TyrPheHisAsnTrpThrGlyAsnArgValThrCysArgAspTrp-309 313 -SerLeuLysGluGly-317 322-ArgAspGlnGluPheSerGlyAspArgAlaGlyArgAlaValArgArgIleGluAsn-340 342-ArgLeuLeuArgGlnAsnGlnPheProGluAspAlaGlyProThrAlaHisProValArgProValSerTyr GluGluMetAsn-369 376-ValTyrGluLysGlyAlaGluVal-383 394-GluGlyPheGlnLysGlyMet-400 404-PheGlnArgHisAspGlyGlnAlaValThrCysAspAspPheArgAlaAlaMet-421 437-SerGlnAlaGlyThrPro-442 444-LeuGluAlaGluGlyArgLeuLysAsnAsnVal-454 459-IleLysGlnThrValProProThrProAspMetAlaAspLysGlnPro-474 483-LeuLeuAsnArgAsnGlyGluAlaVal-491 494-AspTyrGlnGlyLysArgAlaThrGlu-502 508-ThrGluAlaGluGln-512 538-AsnTyrProTyrSerAspAspAspLeu-546 552-HisAspSerAspAla-556 578-LeuSerAspGlyIleGlyLeuProLysHisGluLysLeu-590 594-ValGluLysValIleSerAspAspLeuLeu-603 614-ValProSerGluAlaGluLeuTrpAspGlyThrGluAsnIleAspProLeuArg-631 633-HisGlnAlaArgGluAlaLeu-639 652-HisGluLeuAspArgGlnAlaAlaLysGlnGluAsnGlnSerTyrGluTyrSerProGluThrAlaAsp-67 4 676-ArgThrLeuArgAsnValCys-682 689-AlaAspProAlaHis-693 696-ThrValAlaGluLysTyrGlyGlu-703 718-ValAsnGlyAsnGluSerAspThrArgAsnCys-728 733-PheAlaAspLysPheSerAspAspAlaLeuVal-743 752-GlySerSerArgArgSerAspThrLeuGln-761 768-GlnHisProLysPheSerLeuGluAsnProAsnLysAlaArgSer-782 785-GlySerPheSerArgAsnValPro-792 796-AlaGlnAspGlySerGlyTyrArgPheIleAla-806 808-LysValIleGluIleAspArgPheAsnProGlnVal-819 831-AsnLysLeuGluProHisArgLyεAsnLeuValLysGlnGluLeuGlnCyε-847 849-ArgAlaGlnGluGlyLeuSerLysAspValGlyGluIleVal-862 Hydrophilic Regions - Hopp-Woods l-MetSerLysThrValArgTyrLeuLys-9 32-ThrValValLysSerArgLeuThrValGluProGlnArgAlaGlyGlu-47 81-ValProSerGluArgPheThrVal-88 90-ValGluThrGluIleLeuProAlaGluAsnLysSer-101 116-CysGluProGluGlyPheArg-122 129-AspArgProAspValMetSer-135 142-ValAlaAspLysLysArgTyr-148 154-AsnGlyAsnLysIleAspGlyGlyGluPheSerAsp-165 170-ValLysTrpGluAspProPheAla-177 191-AlaValThrGluAspArgPheThr-198 201-SerGlyArgAsnValLys-206 213-GluAlaAspLysProLysVal-219 23O-MetLysTrpAspGluThrArgPhe-237 258-AlaMetGluAsnLysGly-263 275-AspSerArgThrAlaThrAspThrAspPheGluGlyIleGlu-288 313-SerLeuLysGluGly-317 322-ArgAspGlnGluPheSerGlyAspArgAlaGlyArgAlaValArgArgIleGluAsn-340 348-GlnPheProGluAspAlaGlyPro-355 363-ValSerTyrGluGluMetAsn-369 376-ValTyrGluLysGlyAlaGluVal-383 394-GluGlyPheGlnLysGlyMet-400 406-ArgHisAspGlyGln-410 413-ThrCysAspAspPheArgAlaAlaMet-421 444-LeuGluAlaGluGlyArgLeuLysAsnAsnVal-454 467-ProAspMetAlaAspLysGlnPro-474 495-TyrGlnGlyLysArgAlaThrGlu-502 508-ThrGluAlaGluGln-512 541-TyrSerAspAspAspLeu-546 552-HisAspSerAspAla-556 585-ProLysHisGluLysLeu-590 594-ValGluLysValIleSer-599 616-SerGluAlaGluLeu-620 622-AspGlyThrGluAsnIleAspPro-629 633-HisGlnAlaArgGluAlaLeu-639 652-HisGluLeuAspArgGlnAlaAlaLysGlnGluAsnGlnSer-665 668-TyrSerProGluThrAlaAsp-674 689-AlaAspProAlaHis-693 696-ThrValAlaGluLysTyrGlyGlu-703 719-AsnGlyAsnGluSerAspThrArgAsn-727 733-PheAlaAspLysPheSerAspAspAlaLeuVal-743 753-SerSerArgArgSerAspThrLeu-760 776-AsnProAsnLysAlaArgSer-782 797-GlnAspGlySerGly-801 808-LysValIleGluIleAspArgPheAsn-816 831-AsnLysLeuGluProHisArgLysAsnLeuValLysGlnGluLeuGlnCys-847 849-ArgAlaGlnGluGlyLeuSerLysAspValGlyGluIleVal-862 g666 AMPHI Regions - AMPHI 24-AlaLeuIleMetSerMetVal-30 57-HisThrProGluHisValThrGly-64 89-GlyTyrAspl1eLeuLysGlnGlyGlySer-98 162-LeuLysPheMetGluAlaValVal-169 Antigenic Index - Jameson-Wolf 6-TyrGlnSerAsnSerGlyGluGlyValLeu-15 40-AsnGlnGlyLysValAsnThr-46 55-AspAlaHisThrProGluHis-61 63-ThrGlyLeuThrGluGlnLysGln-70 80-SerAlaAsnProLeuAla-85 92-IleLeuLysGlnGlyGlySerAlaAla-100 114-GluProGlnSerSerGlyLeuGlyGly-122 130-AspAεnThrAlaLysThr-135 137-ThrThrPheAspGlyArgGluThrAlaPro-146 154-PheLeuAspLysAspGlyXxxProLeuLys-163 Hydrophilic Regions - Hopp-Woods 40-AsnGlnGlyLysValAsnThr-46 66-ThrGluGlnLysGln-70 96-GlyGlySerAlaAla-100 139-PheAspGlyArgGluThrAlaPro-146 154-PheLeuAspLysAspGlyXxxPro-161 g667 AMPHI Regions - AMPHI 46-PheAlaIleIleAlaAsp-51 56-AlaArgValGluArgPheProHisPheAlaAla-66 71-LeuAlaArgLysAlaAlaGlnPhe-78 115-IleAlaAlaValAlaGluIle-121 153-AlaAspGlnLeuArgArgMetPhePheAsnGlnPheGluLysLeuGlyAsnHisAsp-171 202-GluValValLeuHisLysIleAlaAlaGlyLeu-212 Antigenic Index - Jameson-Wolf 7-LeuGlyGlyGluIleValSerAspProCysAspPhe-18 25-ValGluSerAlaAlaAspGlnThrGluThrGln-35 56-AlaArgValGluArg-60 71-LeuAlaArgLysAlaAlaGln-77 84-ArgHisIleArgProArgLeuValLysArgGluGlnl1e-96 152-ProAlaAspGlnLeuArg-157 165-GluLysLeuGlyAsnHisAspPhe-172 192-HisThrAlaGlyAsnArgHisAsnLeu-200 225-ValIleArgGlnGlyArgArgGlnVal11eGlnArgThrAspThrLeu-240 248-IleGluSerGlnAsnArgIleHisGlySerThrLeuHisSerLysThrAspLeu-265 Hydrophilic Regions - Hopp-Woods H-IleValSerAspProCysAsp-17 25-ValGluSerAlaAlaAspGlnThrGluThrGln-35 56-AlaArgValGluArg-60 71-LeuAlaArgLysAlaAlaGln-77 84-ArgHisIleArgProArgLeuValLysArgGluGlnIle-96 165-GluLyεLeuGlyAsn-169 227-ArgGlnGlyArgArgGlnValIleGlnArgThrAspThr-239 250-SerGlnAsnArgIleHis-255 259-LeuHisSerLysThrAspLeu-265 g669 AMPHI Regions - AMPHI 24-LysLeuHisArgAlaPhe-29 59-GlnIlePheArgHisValGlnSer-66 79-LysProProAsnThrAla-84 Antigenic Index - Jameson-Wolf l-MetArgArgIleValLysLysHiεGlnProValAsnAla-13 33-GlyArgLysArgProHisHisHisAspArgSerLeuArgArgGlnHisGlyIleGluGlyMetGlyPhe-55 64-ValGlnSerSerAsnArgGlnSerGlyArgGlnProValCysThrLysProProAεnThrAlaSer-85 100-AlaAspIleLysArgIleLeu-106 Hydrophilic Regions - Hopp-Woods 1-MetArgArgIleValLysLyεHisGlnPro-lO 33-GlyArgLysArgProHisHisHisAspArgSerLeuArgArgGlnHisGly-49 65-GlnSerSerAsnArgGlnSerGlyArgGlnProValCysThrLysProProAsn-82 100-AlaAspIleLysArgIleLeu-106 g670 AMPHI Regions - AMPHI 10-ArgSerCysPheGly-14 16-ValLysAsnAlaSerGlyValSer-23 34-IleThrArgSerAla-38 126-PheSerAlaCysSerAlaPheCyεProLeu-135 Antigenic Index - Jameson-Wolf 4-CysArgAsnCysLeuAlaArgSerCys-12 18-AsnAlaSerGlyValSerSerSerArgIleCysProLeuSer-31 33-LysIleThrArgSerAlaThrSerArgAlaAsnProIle-45 65-AsnThrSerProThrIleSerGlySerSerAlaGluValGlySerSerAsnSerIleThrArgGlySerIleA laSerProArgAlaIleAla-95 100-TrpProProGluSerTrpGluGlyLysAla-109 114-AlaSerProThrArgSerLysSerSer-122 128-AlaCysSerAlaPhe-132 146-AsnThrValArgCysGly-151 Hydrophilic Regions - Hopp-Woods 33-LysIleThrArgSerAlaThrSerArgAlaAsn-43 73-SerSerAlaGluValGlySer-79 116-ProThrArgSerLysSer-121 g671 AMPHI Regions - AMPHI ll-PheAsnAlaProAsn-15 72-LysGlyAlaAlaLys-76 119-ArgLeuPheIleArgTyr-124 Antigenic Index - Jameson-Wolf 9-ThrProPheAsnAlaProAsnThrProProLysMetArgLeuAlaLysProArgProThrAlaGluThrAlaPr oValSerSerGluArg-38 45-GlnAlaMetThrAsnArgGluMetAsnAspArgAlaAsnAlaAsnArgArgGlyTrpAsnGluAlaLysAlaA rgSerAlaLysGlyAlaAla-75 77-SerLeuAlaLysLysLysGluThrThr-85 110-AlaGluAlaArgArgSerAlaMet-117 Hydrophilic Regions - Hopp-Woods 16-ThrProProLysMetArgLeuAlaLysProArgProThrAlaGlu-30 32-AlaProValSerSerGluArg-38 47-MetThrAsnArgGluMetAsnAspArgAlaAsnAlaAsnArgArgGlyTrpAsnGluAlaLysAlaArgSerA laLysGlyAlaAla-75 77-SerLeuAlaLysLysLysGluThrThr-85 110-AlaGluAlaArgArgSerAlaMet-117 g672 AMPHI Regions - AMPHI 38-ArgAlaIleAspIleIleLysAlaGlnLys-47 50-AlaAlaLeuProProPheValSerValVal-59 67-AlaGlnAsnIleArgArgIleLeuAlaGluValPro-78 91-AlaPheCysArgGlnPheAspArgProTyr-100 105-ArgValGlnThrAlaSerAspIle-112 115-AlaAlaThrArgPheProAsn-121 131-HisProSerGluTyrGly-136 163-ProGluAsnValGlyGluAlaValArg-171 173-ThrGlyAlaGluAla-177 Antigenic Index - Jameson-Wolf l-MetArgLysIleArgThrLysIleCysGlyIleThrThrProGluAspAlaLeu-18 34-ProGlnSerProArgAlaIleAεpIleIleLysAlaGlnLys-47 65-GluSerAlaGlnAsnIleArgArgIleLeuAla-75 84-PheHisGlyAspGluAspAspAlaPhe-92 95-GlnPheAspArgProTyrIle-101 107-GlnThrAlaSerAspIleArgAsnAlaAla-116 130-TyrHisProSerGluTyrGlyGlyThrGlyHisArgPheAsp-143 149-GluTyrSerGlyLysPro-154 159-GlyGlyLeuThrProGluAsnValGlyGluAlaValArg-171 176-GluAlaValAspValSerGlyGlyValGluAlaSerLysGlyLysLysAspProAlaLys-195 202-ThrAlaAsnArgLeuSerArg-208 Hydrophilic Regions - Hopp-Woods 1-MetArgLys11eArgThrLys11e-8 13-ThrProGluAspAlaLeu-18 36-SerProArgAlaIleAsp-41 43-IleLysAlaGlnLys-47 66-SerAlaGlnAsnIleArgArgIleLeuAla-75 85-HisGlyAspGluAspAspAlaPhe-92 110-SerAspIleArgAsnAlaAla-116 165-AsnValGlyGluAlaValArg-171 184-ValGluAlaSerLysGlyLysLysAspProAlaLys-195 204-AsnArgLeuSerArg-208 g673 AMPHI Regions - AMPHI 84-LeuAsnAspArgLeuAsnGlnAsnValThrGluAlaLeuGlyGlyValAspVal-101 110-ArgLeuThrAspAla-114 117-ValValLeuLysGlnLeuProLyε-124 172-ArgIleAlaAsnLeuLeuGluLeuLeuLysProTyrLeu-184 212-LysLeuPheArgTyrLeuGlyGluGlu-220 232-PheGluGluGlyAspGly-237 261-GlyGluArgLeuLysLysIleSerThr-269 286-LysValTrpValLysValLys-292 Antigenic Index - Jameson-Wolf 7-LeuAlaGlyGluArgAlaAlaGlyGlyTyrArg-17 24-ValGlyArgProAsnValGlyLysSerThr-33 44-SerIleThrSerLyεLysAlaGlnThrThrArgAsnArgValThr-58 61-TyrThr spAεpThrAla-66 73-ThrProGlyPheGlnThrAspHisArgAεnAlaLeuAsnAspArgLeuAsnGlnAsnValThrGlu-94 109-MetArgLeuThrAspAlaAspArgValVal-118 121-GlnLeuProLysHisThr-126 134-LysIleAspLysAspLysAlaLysAspArgTyrAla-145 153-ValArgAlaGluPhe-157 180-LeuLysProTyrLeuProGluSerVal-188 190-MetTyrProGluAspMetValThrAspLysSerAlaArg-202 208-IleValArgGluLysLeuPhe-214 217-LeuGlyGluGluLeuPro-222 227-ValGluValGluGlnPheGluGluGlyAspGlyLeuAsn-239 247-ValAspLysGluSerGlnLys-253 258-GlyLysGlyGlyGluArgLeuLysLysIleSerThrGluAlaArgLeuAspMetGluLysLeuPheAspAsn LysVal-283 291-ValLysSerGlyTrpAlaAspAspIleArgPheLeuArg-303 Hydrophilic Regions - Hopp-Woods 7-LeuAlaGlyGluArgAlaAlaGly-14 45-1leThrSerLyΞLysAlaGlnThrThrArgAsnArgVal-57 61-TyrThrAspAspThrAla-66 78-ThrAspHisArgAsnAlaLeuAsnAspArgLeuAsn-89 109-MetArgLeuThrAspAlaAspArgValVal-118 134-LysIleAspLysAspLysAlaLysAspArgTyrAla-145 153-ValArgAlaGluPhe-157 194-AspMetValThrAspLysSerAlaArg-202 208-IleValArgGluLysLeuPhe-214 217-LeuGlyGluGluLeuPro-222 227-ValGluValGluGlnPheGluGluGlyAspGlyLeuAsn-239 247-ValAspLyεGluSerGlnLys-253 259-LysGlyGlyGluArgLeuLyεLysIleSerThrGluAlaArgLeuAspMetGluLysLeuPheAsp-280 293-SerGlyTrpAlaAspAspIleArgPheLeuArg-303 g674 AMPHI Regions - AMPHI 16-ValTyrGlnSerLeuIle-21 24-ThrAlaAlaProGluIleAlaLysAsnIleArgGluMetSerAspPheAlaLysAlaAspGluGluLeu-46 58-AlaAlaAspTyrIleGlnLysIleArg-66 86-ThrAlaCysHisGluLeuSerAlaMetProGluThr-97 107-IleGluValThrLysThrPheGlyGlyThrAspGlyHisLysPheValAsnGlyIleLeuAspLysLeuAla -130 Antigenic Index - Jameson-Wolf l-MetLysThrAlaArgArgArgSerArgGluLeuAla-12 28-GluIleAlaLysAsnIleArgGluMetSerAspPheAlaLysAlaAspGluGluLeuPhe-47 54-ThrGlnThrAsnAla-58 61-TyrIleGlnLysIleArgProLeuLeuAspArgAspGluLysAspLeuAsnProIleGluArg-81 93-AlaMetProGluThrProTyr-99 105-GluAlaIleGluValThrLysThrPheGlyGlyThrAspGlyHisLysPhe-121 129-LeuAlaAlaGlnIleArgProAspGluProLysArgArg-141 Hydrophilic Regions - Hopp-Woods l-MetLysThrAlaArgArgArgSerArgGluLeuAla-12 28-GluIleAlaLysAsnIleArgGluMetSerAspPheAlaLysAlaAspGluGluLeuPhe-47 63-GlnLysIleArgProLeuLeuAspArgAspGluLysAspLeuAsnProIleGluArg-81 105-GluAlaIleGluVal-109 133-IleArgProAspGluProLysArgArg-141 g675 AMPHI Regions - AMPHI 21-ArgPheThrAsnGluIleGlySerGlnMetLeuLysValCysCysArgThrLeuGlnGluLeuGly-42 74-AlaLeuIleAlaIle-78 123-GlnAlaIleGluArgIleGlyGluLysAlaSerAsp-134 141-GluCysAlaAsnLeuValAsnLeuLeuLeuGlu-151 Antigenic Index - Jameson-Wolf 6-ProAsnLeuAspGlyLysHisLeuArg-14 42-GlyValAlaAspGluAsnIle-48 68-SerSerGluLysPheAsp-73 82-IleArgGlyGluThrTyr-87 93-AlaAsnGluSerGlyAlaGlyIle-100 118-ThrGluAsnAspAlaGlnAlaIleGluArgIleGlyGluLysAlaSerAspAlaAlaLysValAlaVal-14 0 152-GluGlnPheGluAspGluGlu-158 Hydrophilic Regions - Hopp-Woods 8-LeuAspGlyLyεHiεLeuArg-14 42-GlyValAlaAspGluAsnIle-48 68-SerSerGluLysPheAsp-73 82-IleArgGlyGluThrTyr-87 95-GluSerGlyAlaGly-99 118-ThrGluAsnAspAlaGlnAlaIleGluArgIleGlyGluLysAlaSerAspAlaAlaLysValAlaVal-14 0 152-GluGlnPheGluAspGluGlu-158 g677 AMPHI Regions - AMPHI 19-ThrValArgLeuCysArgPheArgArg-27 45-LeuThrAlaPheArgArgValGlnAsnHisPheValAlaPheAlaArgPheAsnGlnAlaThrArgGlnArgA rg-69 79-IleAspPheIleAspAlaAsp-85 87-PheAspGlyLeuLeuAla-92 155-CysArgProValAspAspLeuAspAsp-163 166-AlaPhePheIleAspGlnLeuIleLysLeuValPheGlnCys-179 Antigenic Index - Jameson-Wolf 23-CysArgPheArgArgHisSerArgSerValAsp-33 35-AspValPheAspArgLysAspPheAsnPhe-44 63-GlnAlaThrArgGlnArgArgAsnProArgAsnPheVal-75 82-1leAspAlaAspAspPheAspGly-89 97-GlnGlnThrAspGlyArgAlaGluLys-105 115-GlyIleAspAspAspGlySerLeu-122 125-PheGlyGlnGluThrAspAlaAlaVal-133 156-ArgProValAspAspLeuAspAspPheGly-165 181-ProSerGlyGlyArgAsn-186 Hydrophilic Regions - Hopp-Woods 23-CysArgPheArgArgHisSerArgSerValAsp-33 35-AspValPheAspArgLysAspPhe-42 63-GlnAlaThrArgGlnArgArgAsnProArg-72 82-1leAspAlaAspAspPheAsp-88 97-GlnGlnThrAspGlyArgAlaGluLys-105 115-GlyIleAspAspAspGlySer-121 126-GlyGlnGluThrAspAlaAlaVal-133 156-ArgProValAspAspLeuAspAsp-163 g678 AMPHI Regions - AMPHI 24-MetArgGlyValIle-28 47-PheAlaAlaProPhe-51 80-IleGlnLysMetLeuArgSerLeuLeuThrGlyAla-91 102-ArgIleLeuGlyGlyValPheGlyAlaLeu-lll 130-ProAspThrGluGlu-134 Antigenic Index - Jameson-Wolf 125-SerLysThrAspLeuProAspThrGluGluTrpGlnGlnSerTyr-139 153-AsnHisThrAspAsnAlaProGluSerLeuAspAspAsp-165 Hydrophilic Regions - Hopp-Woods 125-SerLysThrAspLeuProAspThrGluGluTrpGln-136 155-ThrAεpAεnAlaProGluSerLeuAspAspAsp-165 g681 AMPHI Regions - AMPHI 12-PheSerGluGluAlaLysPheIleSerAlaMet-22 110-CysAlaValPheGlyLysLeuProArg-118 123-LeuGlyLysGlnCysGly-128 137-ValGlyGluAlaAspAspAla-143 146-ValGlyValValGlyValPheVal-153 202-LysCysValHisCysGlyAsnThr-209 212-GlyGlyLysLeuAlaAspPheThrThrIleProAla-223 235-CysAlaProPheAlaAlaLeuArgCysPheCysIlePheGlyValTrpLysArgIleArgAlaValPheCys GlyArg-260 Antigenic Index - Jameson-Wolf ll-AsnPheSerGluGluAlaLysPhe-18 39-AlaThrProAsnSerTrpArgValArgGlnGln-49 59-LeuValLysArgAlaCys-64 67-ProMetArgArgCysLeuProSerArgLeu-76 91-SerGluCysArgLeuLys-96 122-GlyLeuGlyLysGlnCysGlyGlyPhe-130 134-PheGlyAspValGlyGluAlaAspAspAlaGluVal-145 157-AlaAlaGluGluThrPro-162 173-AlaValLysGluAlaAspGly-179 185-AspGlyValGlyGlyAspAlaAlaValGluCysArgGlyLysCysLeuCys-201 209-ThrLeuGlyGlyGlyLysLeuAlaAsp-217 224-LeuSerAlaAspGlyGlyGly-230 257-PheCysGlyArgArg-261 Hydrophilic Regions - Hopp-Woods H-AsnPheSerGluGluAlaLysPhe-18 44-TrpArgValArgGln-48 59-LeuValLysArgAlaCys-64 67-ProMetArgArgCysLeuPro-73 91-SerGluCysArgLeuLys-96 136-AspValGlyGluAlaAspAspAlaGluVal-145 157-AlaAlaGluGluThrPro-162 173-AlaValLysGluAlaAspGly-179 191-AlaAlaValGluCysArgGlyLysCysLeu-200 257-PheCysGlyArgArg-261 g682 AMPHI Regions - AMPHI 33-ArgLeuArgLysCysGlyArgIleLeuSerGlyIleCysGluProPhe-48 75-IleLysMetProSerGluPro-81 91-AlaGlyPheIleArgPhePro-97 Antigenic Index - Jameson-Wolf 9-ProTyrGlyGluArgArgLysAsnTrpAsp-18 29-LeuSerProThrArgLeuArgLysCysGlyArg-39 70-CysValAsnAspGluIleLysMetProSerGluProAspTrp-83 95-ArgPheProThrAspArgPro11eLeu-103 112-IleSerProArgThrGlyPheArgTyrProThrArgSerLeuProLysSerLysLysAlaTyrGly-133 Hydrophilic Regions - Hopp-Woods 11-GlyGluArgArgLysAsnTrpAsp-18 30-SerProThrArgLeuArgLysCysGlyArg-39 72-AsnAspGluIleLysMetProSerGluProAspTrp-83 97-ProThrAspArgProIleLeu-103 124-SerLeuProLysSerLysLysAlaTyrGly-133 g683 AMPHI Regions - AMPHI 26-ThrProAspLysSerAlaArgTrpGluAsnIleGlyThrIleSerAsn-41 75-ArgPheAlaAsnThrPro-80 101-SerSerLeuGlnLeuPhe-106 124-ArgProMetSerIleLeuSerGly-131 Antigenic Index - Jameson-Wolf 24-CysSerThrProAspLysSerAlaArgTrpGluAsn-35 37-GlyThrIleSerAsnGly-42 48-1leAsnLysAspSerValArgLysAsnGlyAsn-58 63-GlnAspLysLysValValThrAsnLeuLysGlnGluArgPheAlaAsnThrProAlaTyr-82 93-CysAsnAsnLysThrTyrArgLeu-100 106-PheAspThrLysAsnThrGluIleSerThrGlnAsnTyrThrAlaSerSerLeuArgPro-125 131-GlyThrLeuThrGluLysGlnTyrGlu-139 141-ValCysGlyLysLysLeu-146 Hydrophilic Regions - Hopp-Woods 25-SerThrProAspLysSerAlaArgTrpGluAsn-35 48-11eAsnLysAspSerValArgLysAsnGly-57 63-GlnAspLysLysValValThr-69 71-LeuLysGlnGluArgPheAla-77 107-AspThrLysAsnThrGluIleSer-114 133-LeuThrGluLysGlnTyrGlu-139 141-ValCysGlyLysLysLeu-146 g684 AMPHI Regions - AMPHI 13-AlaAlaCysGlyThrValGln-19 47-LeuAlaGluProLeu-51 73-TrpAlaAspThrLeuAspAspMetLeuGluAlaAlaLeuSerAsnAlaPheAsnArgLeuAspSerThrArg- 96 110-TrpThrValTyrIleAspAlaPheGlnGlySerTyr-121 154-AlaMetThrAlaAlaLeuGluGlnGlyLeuLysGlnAlaAlaGlnGlnMetVal-171 Antigenic Index - Jameson-Wolf 26-LeuProAspSerArgTyrIleArgProAlaThrGlnGlyGlyGluThrAlaValGluValArgLeuAlaGluP roLeuLysArgGlyGlyLeu-56 60-ThrAspProTyrArglleAsnThrAlaGln-69 76-ThrLeuAspAspMetLeuGlu-82 90-AsnArgLeuAspSerThrArgThrPhe-98 101-AlaSerArgSerGlySerThrAspLys-109 117-PheGlnGlySerTyrThrGlyLysThrLeu-126 133-LeuProAspGlyThrAsnArgProPheHisIleGluThrGluGlnGlnGlyAspGlyTyrAla-153 161-GlnGlyLeuLysGlnAlaAla-167 Hydrophilic Regions - Hopp-Woods 27-ProAspSerArgTyrIleArg-33 35-AlaThrGlnGlyGlyGluThrAlaValGluValArgLeuAlaGluProLeuLysArgGlyGly-55 76-ThrLeuAspAspMetLeuGlu-82 90-AsnArgLeuAspSerThrArg-96 102-SerArgSerGlySerThrAspLys-109 141-PheHisIleGluThrGluGlnGlnGlyAsp-150 161-GlnGlyLeuLysGlnAlaAla-167 g685 AMPHI Regions - AMPHI 7-AsnPheAlaPheCysGlyValVal-14 44-CysAlaValLeuPro-48 61-ValSerAlaAlaSerGln-66 98-TrpAlaAlaLeuAspThrLeuThrGluPro-107 141-CysGluSerLeuHisArgHis-147 158-GlyAlaGluAlaTyrGluGlnLeuAlaLysAsn-168 186-GluLysGlnMetGluThrLeuSerArgIlePheGly-197 300-AlaValGluValLeu-304 340-AlaAlaGluGlnLeuLysAlaAla-347 Antigenic Index - Jameson-Wolf 20-LeuAsnAεnLysHisSerTyrSerTyrAlaLysGluProHisThrValLysProArgPhe-39 51-CysSerProGluProAlaAlaGluLysThrValSer-62 78-ProThrAlaArgGlyAspAlaValValProLysAsnProGluArgValAla-94 103-ThrLeuThrGluProGlyVal-109 126-AlaPheAspLysAlaAla-131 137-PheGluProAspCysGluSerLeuHisArgHisAsnPro-149 155-GlyGlyProGlyAlaGluAlaTyrGluGlnLeuAlaLysAεnAlaThr-170 174-LeuThrValAspAsnGlyAsnIleArgThrSerGlyGluLysGlnMetGluThrLeu-192 195-IlePheGlyLysGluAlaArgValAlaGlu-204 213-PheAlaGlnLysArgGluAlaAlaLysGlyLysGlyArgGlyLeu-227 231-ValThrGlyAsnLysValSerAlaPheGlyThrGlnSerArgLeu-245 251-GlyAspIleGlyLeuProProValAspGluSerLeuArgAsnGluGlyHisGlyGln-269 275-TyrIleLysGluLysAsnProGlyTrp-283 289-ArgThrAlaAlaIleGlyGlnGluGlyProAla-299 313-AsnAlaTrpLysArgLysGln-319 342-GluGlnLeuLysAlaAlaPheGluLysAlaGluProValAla-355 Hydrophilic Regions - Hopp-Woods 28-TyrAlaLysGluProHisThrValLys-36 51-CysSerProGluProAlaAlaGluLysThrValSer-62 79-ThrAlaArgGlyAspAlaValVal-86 88-LysAsnProGluArgValAla-94 126-AlaPheAspLysAlaAla-131 137-PheGluProAspCysGluSerLeuHisArgHis-147 160-GluAlaTyrGluGlnLeuAlaLys-167 179-GlyAsnIleArgThrSerGlyGluLysGlnMetGluThrLeu-192 195-IlePheGlyLysGluAlaArgValAlaGlu-204 213-PheAlaGlnLysArgGluAlaAlaLysGlyLysGlyArgGly-226 257-ProValAspGluSerLeuArgAsnGluGlyHisGly-268 275-TyrIleLysGluLysAsnPro-281 294-GlyGlnGluGlyProAla-299 314-AlaTrpLysArgLysGln-319 342-GluGlnLeuLysAlaAlaPheGluLysAlaGluProValAla-355 g686 AMPHI Regions - AMPHI 10-AspValPheAspAspIleCysSerAlaValGluGlyPheGlyGlyIleAlaArgSerValGlnLeu-31 50-SerAlaGlyIleValGluThrValGlyLysProLeu-61 70-ValGluAlaAspIle-74 86-IleProArgAlaPheGlySerGlyIleAlaAlaAlaLeu-98 Antigenic Index - Jameson-Wolf l-TerTerAsnPheSerCysArgAlaAspAspValPheAsp-13 46-LeuArgGlnHisSerAlaGlyIle-53 56-ThrValGlyLyεProLeuSerGlyAla-64 70-ValGluAlaAεpIle-74 115-AspAlaValLysAlaGluSerValAsnGlyThrThrGly-127 Hydrophilic Regions - Hopp-Woods 6-CysArgAlaAspAspValPheAsp-13 70-ValGluAlaAspIle-74 115-AspAlaValLysAlaGluSerValAsn-123 g687 AMPHI Regions - AMPHI 13-AlaAlaLeuPheAlaLeu-18 66-LyεValGluValLeuGluPhePheGlyTyrPheCysPro-78 80-CyεAlaArgLeuGluPro-85 87-LeuSerLysHisAlaLysSerPhe-94 114-LeuAlaArgLeuAlaAlaAla-120 137-PheAspAlaMetVal-141 150-ProGluValLeuLysLysTrpLeu-157 174-SerProGluSerGln-178 182-GlyLysMetGlnGluLeuThrGluThrPhe-191 Antigenic Index - Jameson-Wolf l-MetLysSerArgHis-5 21-CysAspSerLysValGlnThrSerValProAlaAspSerAlaPro-35 45-GlyLeuValGluGlyGlnAsnTyr-52 58-ProIleProGlnGlnGlnAlaGlyLysValGluVal-69 77-CysProHisCysAlaArgLeuGluProValLeu-87 89-LysHisAlaLysSerPheLysAspAspMetTyrLeu-100 124-AlaAlaAlaGluSerLysAspValAlaAsn-133 143-GlnLysIleLysLeuGlnGluProGluValLeuLys-154 161-ThrAlaPheAspGlyLysLysVal-168 173-GluSerProGluSerGlnAlaArgAlaGlyLysMetGlnGluLeuThrGlu-189 191-PheGlnIleAspGlyThrPro-197 201-ValGlyGlyLysTyrLysValGluPheAlaAsp-211 213-GluSerGlyMetAsnThr-218 222-LeuAlaAspLysValArgGluGluGlnLysAlaAlaGln-234 Hydrophilic Regions - Hopp-Woods l-MetLysSerArgHis-5 21-CysAspSerLysValGlnThr-27 29-ValProAlaAspSerAlaPro-35 63-GlnAlaGlyLysValGluVal-69 81-AlaArgLeuGluProValLeu-87 89-LysHisAlaLysSerPheLysAspAspMetTyrLeu-100 124-AlaAlaAlaGluSerLysAspValAla-132 143-GlnLysIleLysLeuGlnGluProGluValLeuLys-154 161-ThrAlaPheAspGlyLysLysVal-168 173-GluSerProGluSerGlnAlaArgAlaGlyLysMetGlnGluLeuThrGlu-189 203-GlyLysTyrLysValGluPheAlaAsp-211 222-LeuAlaAspLysValArgGluGluGlnLysAlaAlaGln-234 g688 AMPHI Regions - AMPHI 22-LeuSerAlaLeuPheSerLeu-28 119-GlyAspAlaLeuGlnAsnAlaAla-126 Antigenic Index - Jameson-Wolf 5-SerArgPheAlaGlnLysGlySerProValAsnLys-16 31-CysSerValGluArg-35 46-IleIleGlnGlyAsnGluLeuGluProArgAla-56 61-ArgProGlyMetThrLysAspGln-68 81-AlaPheHisThrAspArgTrpAspTyr-89 91-PheAsnThrSerArgAsnGlyIleIleLysGluArgΞerAsnLeu-105 115-ValArgThrGluGlyAεpAlaLeuGlnAsnAlaAlaGluAlaLeuArgAlaLysGlnAsnAlaAspLysGln -138 Hydrophilic Regions - Hopp-Woods 7-PheAlaGlnLysGlySerProVal-14 50-AsnGluLeuGluProArgAla-56 63 -GlyMetThrLysAspGln-68 97-GlyIleIleLysGluArgSerAsn-104 115-ValArgThrGluGlyAεpAlaLeuGlnAsnAlaAlaGluAlaLeuArgAlaLysGlnAsnAlaAspLysGln -138 g689 AMPHI Regions - AMPHI 16-ValLeuMetAlaValLeuValAlaLeu-24 33-LeuProAlaIleProGluMetAlaGln-41 49-ArgIleGluSerLeu-53 62-PheGlyGlnValAlaGlyGly-68 73-IleLysGlyArgLys-77 103-LeuLeuAsnLeuArgAlaValGlnAlaPhe-112 138-PheAlaLeuIleGlyIleIleLeu-145 152-AlaProMetValGlyAlaLeuLeuGlnGlyLeuGlyGlyTrpArgAlaIlePheVal-170 177-ProValLeuProGlyLeuValGlnTyrPhe-186 195-LysIleGlyArgAspVal-200 207-ArgPheLysArgValLeu-212 227-SerPheGlySerMetPheAla-233 288-GlyIleValValGln-292 347-AlaAsnAlaValSerGlyValPheArgSerLeuIle-358 Antigenic Index - Jameson-Wolf l-TerTerSerProProLeuProProMetSerGlyLyε-12 46-AspIleHisArgIleGluSer-52 71-SerAspIleLysGlyArgLysProVal-79 98-SerSerThrGluGln-102 124-MetValArgAspTyrTyrSerGlyArgLysAlaAla-135 189-AsnProAlaValGlyGlyLysIleGlyArgAspVal-200 207-ArgPheLysArgValLeuLysThrArgAla-216 275-LeuLysThrGlyAlaHisProGlnSer-283 340-PheLysGluGluGlyGlySerAla-347 390-LysAlaTrpLysGluAsnGluLysLysArgIleLeu-401 Hydrophilic Regions - Hopp-Woods 46-AspIleHisArgIleGluSer-52 71-SerAspIleLysGlyArgLysProVal-79 128-TyrTyrSerGlyArgLysAlaAla-135 195-LysIleGlyArgAspVal-200 207-ArgPheLysArgValLeuLysThrArgAla-216 340-PheLyΞGluGluGlyGlySer-346 390-LysAlaTrpLysGluAsnGluLysLysArglleLeu-401 g690 AMPHI Regions - AMPHI 38-SerSerAlaSerSer-42 54-SerAlaProAspAsnValLysGlnAla-62 73-HisProAlaAlaGlyIleGlyAspLeuIleGlnGlnIleAlaGluHisIle-89 112-GlyTyrAspAsnIleGlnArgLeu-119 146-ThrArgThrIleSerArgGlnAlaGlnAspAla-156 185-ProLysArgAlaArgTyrPhe-191 209-GlyAsnPheGlnTyrIleGlyGlnLeuProGlyTyrLeuLysMetHisGlyGluMet-227 Antigenic Index - Jameson-Wolf l-MetLysAsnLysThrSerSerLeu-8 20-ArgSerProSerLysGluAspLysThrLysGluAsnGlyAla-33 37-SerSerΞerAlaSerSerAlaΞerSerGlnThrAspLeuGlnPro-51 54-SerAlaProAspAsnValLysGlnAlaGluSerAlaProLeuAsnCysThrGly-71 86-AlaGluHiεIleAspSerAspCys-93 100-AsnGluLeuGluThrArgPhe-106 108-LeuProGlyGlyGlyTyrAspAsnIleGln-117 122-ProAspIleArgProGluAspProAspTyrHisGln-133 140-GluAspLeuArgTyrGlyThrArgThrIleSerArgGlnAlaGln-154 156-AlaIleMetGluGlnGluArgArgLeuArgGluAlaThr-168 173-GlnGlySerGlnLysThrArgGlyGlnGlyGluGluProLysArgAlaArgTyr-190 199-TyrLeuAsnArgHisAsnAsnGlyLeuGlyGlyAsn-210 223-MetHisGlyGluMetLeuGluAsnGlnSerLeu-233 235-ArgLeuSerAsnArgGluArgAsnProAspLysProPheLeu-248 251-HisPheAspGluAsnGlyLysIleThr-259 263-ValTyrGluLysAsnIle-268 Hydrophilic Regions - Hopp-Woods l-MetLysAsnLysThrSer-6 20-ArgSerProSerLysGluAεpLysThrLysGluAsnGlyAla-33 39-SerAlaSerSerAlaSerSerGlnThrAspLeu-49 54-SerAlaProAspAsnValLysGlnAlaGluSerAlaPro-66 87-GluHisIleAspSer-91 100-AsnGluLeuGluThr-104 124-IleArgProGluAspProAspTyrHisGln-133 140-GluAspLeuArgTyrGlyThr-146 148-ThrIleSerArgGlnAlaGln-154 156-AlaIleMetGluGlnGluArgArgLeuArgGluAlaThr-168 174-GlySerGlnLysThrArgGlyGlnGlyGluGluProLysArgAlaArgTyr-190 223-MetHisGlyGluMetLeuGlu-229 236-LeuSerAsnArgGluArgAsnProAspLysProPhe-247 251-HisPheAspGluAsnGlyLysIleThr-259 g691 AMPHI Regions - AMPHI ll-LysProAlaAlaSer-15 55-HisAsnGluLeuArgLysIleArgAla-63 101-AlaArgAspTyrVal-105 Antigenic Index - Jameson-Wolf 7-CysArgPheAlaLys-ll 35-ProProAsnAspPheGlnProAsnCysAspIleArgArgLeuGlyLeuThrGlnGlyGlnHisAsnGluLeuA rgLyεIleArgAla-63 67-MetAlaGlyAspArgAlaArgLeuLyεValMetHis-78 80-GluHisSerArgArgArgSerVal-87 91-IleSerSerAspValPheAsnArgAsnGluAlaArgAspTyrValGluSerArgTyrHisSerSerMet-113 115-PheAlaValAspGluLeuGluIle-122 131-ThrProGlnGlnGlnGln-136 140-SerSerCysLeuLys-144 Hydrophilic Regions - Hopp-Woods 43-CysAspl1eArgArgLeuGly-49 54-GlnHisAsnGluLeuArgLysIleArgAla-63 67-MetAlaGlyAspArgAlaArgLeuLysValMetHis-78 80-GluHisSerArgArgArgSerVal-87 95-ValPheAsnArgAsnGluAlaArgAspTyrValGlu-106 115-PheAlaValAspGluLeuGluIle-122 g692 AMPHI Regions - AMPHI 9-SerGluSerIleArgArgIleTrpArgAsnGlyArgGlu-21 58-PheValAlaLeuGluAla-63 77-LeuGlyTyrValPheLysProLeuAlaValPheVal-88 106-GlnGlyPheGlyGlnLeuHis-112 143-PheAspValPheGlnValPheArgAsp-151 179-CysGluValGlyArgValValGlyArgGlyTyrGlyAlaAlaValPheAspPhePheGlnArgPheGlnPhe -202 205-IleGlnSerGlnArgArgGlyArgHisLeuGluGlyPheGlyAsp-219 254-ValGlyLysPheAspGlnPheAspGlyVal-263 275-PheAspHisIleAlaGluVal-281 302-GlyGlyArgGlyCys-306 Antigenic Index - Jameson-Wolf 4-ThrArgCysArgCysSerGluSerIleArgArgIleTrpArgAsnGlyArgGluTrpArgIleLysGlyGlnLy sCysArgLeuAsnThrAspAlaValGln-37 89-GlyGlyPheAspGlyArgProValAspIleGlyLysAlaArgLeuLeuGlu-105 120-AlaValAspAspGlyLysIle-126 136-CysGlyPheLysLeuAspAspPheAspVal-145 150-ArgAspValGlyPheGlyCysGlyGlnArgIle-160 177-GlyAlaCysGluValGlyArgValValGlyArgGlyTyr-189 204-ArgIleGlnSerGlnArgArgGlyArgHisLeuGluGlyPheGlyAsp-219 236-GluAspValAspVal-240 256-LysPheAspGlnPheAspGlyVal-263 282-AlaHisGlyArgAlaGluAspAspPhePhePhe-292 296-ValIleGlyArgArgGlyGlyGlyArgGlyCysGlyArg-308 316-GlyCysGluAspGluArgGluCysGlyGlyGlyLysGlyPheGluGlu-331 Hydrophilic Regions - Hopp-Woods 4-ThrArgCysArgCysSerGluSerIleArgArgIleTrpArgAsnGlyArgGluTrpArgIleLysGlyGlnLy sCysArgLeuAsnThr-33 91-PheAspGlyArgProValAspIleGlyLysAlaArgLeuLeuGlu-105 120-AlaValAspAspGlyLysIle-126 139-LysLeuAspAspPheAsp-144 179-CysGluValGlyArgValValGly-186 206-GlnSerGlnArgArgGlyArgHisLeuGluGlyPheGly-218 236-GluAspValAspVal-240 282-AlaHisGlyArgAlaGluAspAspPhePhePhe-292 296-ValIleGlyArgArgGlyGlyGlyArgGlyCysGly-307 316-GlyCysGluAspGluArgGluCysGlyGly-325 327-LysGlyPheGluGlu-331 g694 AMPHI Regions - AMPHI 13-LeuThrProAlaSerThr-18 69-ArgGlyArgAlaCysArg-74 88-GlnValGlyArgValVal-93 103-CysArgHisPheAlaGln-108 110-ValAlaValGlyArgIleGly-116 139-ArgArgIleAlaAspValPheLeuVal-147 149-IleAlaAspIleGlyGlu-154 171-ArgGlyLeuAlaAspIleGlyGluPheValGlyValSerAsp-184 194-PheAspGlnLysHisPheAlaArgCys-202 238-HisGlnArgAlaSerArgIleLys-245 270-ArgAlaArgArgHisPheArgGlnValPheAsp-280 298-AspPheValAlaHisIle-303 327-AlaAlaArgIleGlyLysAspAsp-334 Antigenic Index - Jameson-Wolf 34-GlyGlnAspGluHisAspAla-40 45-ProProPheAlaHisGlyPhe-51 53-ProProSerAlaTyrGlyCysGln-60 63-ProHisGlnHisPheGlyArgGlyArgAlaCysArgTyr-75 82-PheLysProArgAla-86 97-ArgIleAspSerAlaArgCysArgHis-105 113-GlyArgIleGlyArgThrAspHisAsnHisAsp-123 130-LeuPheAspGlyGlyLeuProValGlyArgArgIleAla-142 150-AlaAspIleGlyGluThrArgValGlnArgGlyAspAsp-162 167-1leAspArgGluArgGlyLeuAlaAsp-175 189-HisIleSerAspArgPheAspGlnLysHisPheAla-200 202-CysLysLeuProHisArgAlaPheAsp-210 214-ProLeuMetProAspHisAspAspPheThr-223 237-ArgHisGlnArgAlaSerArgIleLysTyrProGluThrAlaLeu-251 265-ArgIleAsnGlnCysArgAlaArgArgHisPhe-275 278-ValPheAspLysHisArg-283 303-IleAsnArgArgAlaGluPhe-309 313-ThrPheAspAsnThrAspCysProIleHisThrGlyAlaGluAlaAlaArgIleGlyLysAspAspGlyPhe Ser-337 344-ProCysSerAspGly-348 356-LeuCysAspGlyArgTyrCysGlnAlaProProThrProHisArgArgArg-372 Hydrophilic Regions - Hopp-Woods 34-GlyGlnAspGluHisAspAla-40 68-GlyArgGlyArgAlaCysArg-74 82-PheLysProArgAla-86 97-ArgIleAspSerAlaArgCysArgHis-105 114-ArgIleGlyArgThrAspHisAsnHis-122 137-ValGlyArgArgIleAla-142 150-AlaAspIleGlyGluThrArgValGlnArgGlyAspAsp-162 167-IleAspArgGluArgGlyLeuAlaAsp-175 189-HisIleSerAspArgPheAspGlnLysHisPheAla-200 202-CysLysLeuProHisArgAlaPhe-209 217-ProAspHisAspAsp-221 237-ArgHisGlnArgAlaSerArgIleLysTyrProGluThrAlaLeu-251 267-AsnGlnCysArgAlaArgArgHisPhe-275 278-ValPheAspLysHisArg-283 303-IleAsnArgArgAlaGluPhe-309 314-PheAspAsnThrAsp-318 325-AlaGluAlaAlaArgIleGlyLysAspAspGlyPheSer-337 367-ThrProHisArgArgArg-372 g695 AMPHI Regions - AMPHI 34-GlnAsnSerGlnArg-38 41-SerLysProAlaGluArgTyrAlaAspCysProHis-52 83-AlaSerCysAlaSerValLeu-89 128-ValArgLeuSerAsnGluVal-134 157-ValGlnLysLeuAsp-161 182-ValGluThrAlaGlnAsnLeuTyrAsnGlnAlaLeuLysHisTyrGlnAsnGly-199 237-CysGluSerValIleGluIle-243 247-TyrAlaAsnArgPheLysAspSer-254 277-AlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGly-290 Antigenic Index - Jameson-Wolf 1-LeuProGlnThrArgProAlaArgArgHisHisArgHisArgGlnTyrPheValGluArgLysGlyAspAlaAr gSerGlyPhe-28 32-GlnCysGlnAsnSerGlnArgPheGlnSerLysProAlaGluArgTyrAlaAspCysProHisHisProAlaA rgArgArgArgPheAspProAlaSerGluLysIleMetLysThrLys-71 90-ProValProGluGlySerArgThrGluMetProThrGlnGluAsnAlaSerAspGlyIleProTyr-lll 116-LeuGlnAspArgLeuAspTyrLeuGlu-124 126-LysIleValArgLeuSerAsnGluValGluMetLeuAsnGlyLysValLysAlaLeuGluHisThrLysIle HisProSerGlyArgThrTyrValGlnLysLeuAspAspArgLysLeuLysGlu-167 169-TyrLeuAsnThrGluGlyGlySerAla-177 192-AlaLeuLysHisTyrGlnAsnGlyArg-200 208-LeuLysGlyAlaAspGlyGlyAspGlyGlySerIleAlaGln-221 229-GlnSerArgAlaArgMetGlyAsnCys-237 243-1leGlyGlyArgTyrAlaAsnArgPheLysAspSerProThrAla-257 265-GlyGluCysGlnTyr-269 271-LeuGlnGlnLysAspIleAla-277 288-TyrProGlySerProAlaAlaLysArgAlaAlaAlaAlaValArgLysArg-304 Hydrophilic Regions - Hopp-Woods 2-ProGlnThrArgProAlaArgArgHisHisArgHisArg-14 17-PheValGluArgLysGlyAspAlaArgSer-26 35-AsnSerGlnArgPheGlnSerLysProAlaGluArgTyrAlaAsp-49 51-ProHisHisProAlaArgArgArgArgPheAspProAlaSerGluLysIleMetLysThrLys-71 92-ProGluGlySerArgThrGluMetProThrGlnGluAsnAlaSerAsp-107 116-LeuGlnAspArgLeuAspTyrLeuGlu-124 126-LysIleValArgLeuSerAsnGluValGluMetLeuAsnGlyLysValLysAlaLeuGluHisThrLysIle HisProSerGly-153 156-TyrValGlnLysLeuAspAspArgLysLeuLysGlu-167 209-LysGlyAlaAspGlyGlyAspGlyGlySerIleAlaGln-221 230-SerArgAlaArgMetGlyAsn-236 247-TyrAlaAsnArgPheLysAspSerProThrAla-257 265-GlyGluCysGlnTyr-269 271-LeuGlnGlnLysAspIleAla-277 292-ProAlaAlaLysArgAlaAlaAlaAlaValArgLysArg-304 g700 AMPHI Regions - AMPHI 6-ThrLeuPheSerValLeuValProMetPheAlaGlyPhePheIleArgValProLys-24 51-ArgValGluAspLeuGlySerArg-58 80-AlaLeuAlaValLeuGlyLysLeu-87 189-GlyValSerTrpThrLysGlyLeu-196 204-TrpTyrSerLeuSerGlyLeuVal-211 216-TyrGlyAlaValTrp-220 228-AspLeuAlaArgGluLeu-233 268-GlyAlaGlyGlyLeu-272 Antigenic Index - Jameson-Wolf 21-ArgValProLysProTyrLeuProAlaSerAspLysVal-33 50-SerArgValGluAspLeuGlySerArgLeuGlyAsp-61 88-SerProTrpArgl1eGlyGlyLysGlyLysGlyVal-99 103-ValSerGlySerValArg-108 118-ValSerGlyLysLeuMet-123 128-MetProSerGluAsnAlaGlyMet-135 149-LeuLysSerSerGlyValSerLeu-156 160-LeuLeuAsnArgArgGlyIleArgLeu-168 245-ArgPheProAspAla-249 268-GlyAlaGlyGlyLeu-272 Hydrophilic Regions - Hopp-Woods 29-AlaSerAspLysVal-33 50-SerArgValGluAspLeuGlySerArgLeuGlyAsp-61 92-IleGlyGlyLysGlyLysGlyVal-99 149-LeuLysSerSerGlyValSer-155 160-LeuLeuAsnArgArgGly11eArg-167 g701 AMPHI Regions - AMPHI 6-PheGlnValAlaGly-10 30-CysLeuGluThrSer-34 45-ProAsnSerPheAlaGlyPheLysArgPheSerSerIle-57 79-GlyProAlaProAlaMet-84 Hl-ArgAlaIleSerSerLeu-116 Antigenic Index - Jameson-Wolf 17-AlaGlnSerThrProSerSerProThrMet~26 29-ThrCysLeuGluThrSerProGluAlaGly-38 52-LysArgPheSerSer-56 72-AsnLysAlaAspIleProThrGlyProAla-81 104-GlyLysAlaSerLeuAsnSerArgAla-112 119-SerCysGlyGlyThrArgLeu-125 Hydrophilic Regions - Hopp-Woods 72-AsnLysAlaAspIleProThr-78 g702 AMPHI Regions - AMPHI 51-CysSerGlyLeuValThrValProAla-59 74-AlaSerSerProThrGlyValArgLysValIle-84 Antigenic Index - Jameson-Wolf l-MetProCysSerLysAlaSerTrp-8 10-SerProGlyValAla-14 27-AlaLeuAlaArgAspSerCysLysProGlyLeu-37 41-ThrAlaProAlaSerSer-46 69-AlaIleArgArgMetAlaSerSerProThrGlyValArgLysValIleSer-85 88-GlyMetProProSerThrArgAlaArgAspLysSerThrAla-101 118-ArgIleSerArgGlyValSer-124 Hydrophilic Regions - Hopp-Woods 27-AlaLeuAlaArgAspSerCysLys-34 69-AlaIleArgArgMetAlaSer-75 78-ThrGlyValArgLysValIleSer-85 91-ProSerThrArgAlaArgAspLysSerThrAla-101 118-ArgIleSerArgGlyValSer-124 g703 AMPHI Regions - AMPHI 21-GlnThrLeuAlaThrValAsnGly-28 64-GluValValAsnThrValValAlaGlnGlu-73 79-LeuAspArgSerAlaGlu-84 136-GlnGluValLysAlaValTyrAspAsnIleSerGlyPheTyrLysGly-151 181-PheAspAlaValLeu-185 204-ValProLeuLysAspLeuGluGlnGlyValProProLeuTyrGlnAlaIleLysAspLeuLysLys-225 252-ValProSerPheAsp-256 270-ArgIleAspArgAlaValCys-276 Antigenic Index - Jameson-Wolf l-MetLysAlaLysIle-5 26-ValAsnGlyGlnLysIleAspSerSerVal-35 43-PheArgAlaGluAsnSerArgAlaGluAspThrProGlnLeuArg-57 72-GlnGluValLysArgLeuLysLeuAspArgSerAlaGluPheLysAspAlaLeuAlaLysLeuArgAlaGluA laLysLysSerGlyAspAspLysLysProSerPheLysThr-109 129-LysThrGlnProValSerGluGlnGluValLysAlaValTyr-142 144-AsnIleSerGlyPheTyrLysGlyThrGlnGluValGlnLeu-157 160-IleLeuThrAspLysGluGluAsnAlaLysLysAlaValAlaAspLeuLysAlaLysLysGlyPhe-181 188-TyrSerLeuAsnAspArgThrLysArgThrGlyAlaProAspGlyTyrValPro-205 207-LysAspLeuGluGlnGlyValProPro-215 221-LysAspLeuLysLysGlyGluPheThrAlaThrProLeuLysAsnGlyAspPhe-238 243-TyrValAsnAspSerArgGluValLysValProSerPheAspGluMetLysGly-260 266-LeuGlnAlaGluArgIleAspArgAlaVal-275 282-AlaAsnIleLysProAlaLys-288 Hydrophilic Regions - Hopp-Woods l-MetLysAlaLysIle-5 29-GlnLysIleAspSerSerVal-35 43-PheArgAlaGluAsnSerArgAlaGluAspThrProGlnLeuArg-57 72-GlnGluValLysArgLeuLysLeuAspArgSerAlaGluPheLysAspAlaLeuAlaLysLeuArgAlaGluA laLysLysSerGlyAspAspLysLysProSerPhe-107 131-GlnProValSerGluGlnGluValLysAlaValTyr-142 160-IleLeuThrAspLysGluGluAsnAlaLysLysAlaValAlaAspLeuLysAlaLysLysGlyPhe-181 189-SerLeuAsnAspArgThrLysArgThrGlyAla-199 207-LysAspLeuGluGln-211 221-LysAspLeuLysLysGlyGluPhe-228 245-AsnAspSerArgGluValLysValProSerPheAspGluMetLysGly-260 266-LeuGlnAlaGluArgIleAspArgAlaVal-275 282-AlaAsnIleLysProAlaLys-288 g704 AMPHI Regions - AMPHI 36-AlaValAlaGlnSerIleIleAspSerGlyLeuGly-47 65-GlnGluIleLeuAspGlnIleArgLeuTyrAspLeuProGluValGlnSerAspPheValGluThrHis-87 184-LeuGlyMetMetGln-188 208-LeuGlnIleLeuHisTrpGlyGlyPheLeuMetValLeuPro-221 232-GlnGlyAlaLeuArgAspLeuLys-239 252-AlaIleIleMetThrPheIleAlaGlyIleTyrSer-263 289-PheMetGluHisIleAlaArg-295 298-AlaGlyAspAlaAlaGluArgLeuValLysLeuIleProAlaPheCysHisArgMetProGlyTyrProAla ValGlnAsp-324 326-ArgGluSerAlaValVal-331 400-GlyGlyThrArgLeuSerHis11eValArgLeuLeuAspArgAlaLeuAla-416 423-GluLeuAlaGluGlnTyr-428 499-AlaIleGluThrLeuSerGln-505 527-IleGluLeuLeuGlySerMet-533 574-GlnArgLeuAsnArgIleGlyGluGlyValGly-584 639-LeuLysAspSerAlaAlaGluAlaValArgGlnLeuAla-651 670-GluThrAlaArgAlaLeuGlyIle-677 691-GluTyrValGluAlaLeuGlnLysGlu-699 744-AspLeuArgThrValAlaHisLeuLeuAsp-753 780-AlaValLeuGlyTyrValGlnProTrpIleAlaAla-791 799-LeuAlaValLeuGly-803 Antigenic Index - Jameson-Wolf l-MetLysLysThrCys-5 9-GlyLeuAspValProGluAsn-15 20-ValArgTyrGluGlyGluAspArgGluThrCysCysValGly-33 42-IleAspSerGlyLeuGlySerTyrTyrLysArgArgThrAlaAspAlaLysLysThrGluLeuProProGlnG luIleLeuAsp-69 77-ProGluValGlnSerAspPheValGluThrHisAsnGlyThrHis-91 112-GlnLeuLeuArgThrAspGlyIleVal-120 124-LeuAsnTyrSerThrHisArgCys-131 133-ValValTrpAspAspGlyLysIleArgLeu-142 149-IleArgGlnThrGlyTyr-154 158-ProTyrAspAlaGlnLysIleGluAlaAlaAsnGlnLysGluArgLysGlnTyr-175 199-TyrGlyGlyAspIleGluProAspPhe-207 234-AlaLeuArgAspLeuLysAsnArgArgAlaGlyMetAspThrPro-248 293-IleAlaArgArgLysAlaGlyAspAlaAlaGluArgLeuVal-306 315-ArgMetProGlyTyr-319 323-GlnAspValArgGluSerAlaVal-330 342-LysProGlyGluThrIleProValAspGlyThrVal-353 355-GluGlyAsnSerAlaValAsnGluSer-363 365-LeuThrGlyGluSer-369 374-LysMetProSerGluLysValThrAla-382 393-11eArgThrAspArgThrGlyGlyGlyThrArg-403 414-AlaLeuAlaGlnLysProArgThrAlaGluLeuAlaGlu-426 486-ThrLeuAlaArgGluGlyIle-492 495-GlyGlyLysGlnAlaIle-500 510-IlePheAspLysThrGlyThrLeuThrGlnGlyAsnProAlaValArgArgIleGluLeu-529 544-SerLeuGluGlnGlnSerGluHisProLeu-553 561-ArgIleSerGlyGlySerValPro-568 571-GlnValGlyGlnArgLeuAsnArgIleGlyGluGlyVal-583 589-ValAsnGlyGluThr-593 605-AlaGluIleSerGlyLysGluProGlnThrGluGlyGlyGlySer-619 635-LeuGlnAspProLeuLysAspSerAlaAlaGluAlaValArg-648 650-LeuAlaGlyLysAsnLeu-655 659-IleLeuSerGlyAspArgGluGluAlaValAlaGluThrAlaArg-673 684-AlaMetProGluAspLysLeuGluTyr-692 694-GluAlaLeuGlnLysGluGlyLysLys-702 707-GlyAspGlyIleAsnAspAla-713 727-GlyGlyThrAspIleAlaArgAspGlyAlaAsp-737 743-GluAspLeuArgThr-747 753-AspGlnAlaArgArgThrArgHisIleIle-762 807-ArgLeuHisLysArgGlyGluMetProSerGluGln-818 Hydrophilic Regions - Hopp-Woods l-MetLysLysThrCys-5 22-TyrGluGlyGluAspArgGluThrCys-30 50-TyrLysArgArgThrAlaAspAlaLysLysThrGluLeuProPro-64 77-ProGluValGlnSerAspPheValGlu-85 87-HisAsnGlyThrHis-91 112-GlnLeuLeuArgThrAspGlyIleVal-120 133-ValValTrpAspAspGlyLysIleArgLeu-142 160-AspAlaGlnLysIleGluAlaAlaAsnGlnLysGluArgLysGlnTyr-175 201-GlyAspIleGluProAspPhe-207 234-AlaLeuArgAspLeuLysAsnArgArgAlaGlyMet-245 293-IleAlaArgArgLysAlaGlyAspAlaAlaGluArgLeuVal-306 323-GlnAspValArgGluSerAlaVal-330 375-MetProSerGluLysValThr-381 393-IleArgThrAspArgThrGlyGlyGlyThrArg-403 414-AlaLeuAlaGlnLysProArgThrAlaGluLeuAlaGlu-426 486-ThrLeuAlaArgGluGlyIle-492 522-ProAlaValArgArgIleGluLeu-529 545-LeuGluGlnGlnSerGluHisProLeu-553 574-GlnArgLeuAsnArgIleGlyGlu-581 607-IleSerGlyLysGluProGlnThrGluGlyGlyGly-618 637-AspProLeuLysAspSerAlaAlaGluAlaValArg-648 661-SerGlyAspArgGluGluAlaValAlaGluThrAlaArg-673 684-AlaMetProGluAspLysLeuGluTyr-692 694-GluAlaLeuGlnLysGluGlyLysLys-702 730-AspIleAlaArgAspGlyAlaAsp-737 743-GluAspLeuArgThr-747 753-AspGlnAlaArgArgThrArgHisIleIle-762 807-ArgLeuHisLysArgGlyGluMetProSerGluGln-818 g705 AMPHI Regions - AMPHI 67-LysCysLeuLeuLysLeu-72 104-AsnProIleProAla-108 147-TyrMetGlnThrPheArgArgIleValAlaProGln-158 169-AsnGluPhelleGlyLeuPheLysAsn-177 183-ValValThrValThrGluLeuPheArgValAlaGln-194 196-ThrAlaAsnArgThr-200 Antigenic Index - Jameson-Wolf 13-ThrGluThrArgAlaAspMet-19 132-ValProLysGlyGlnTrpGlu-138 165-ProProLeuSerAsnGlu-170 193-AlaGlnGluThrAlaAsnArgThrTyrAsp-202 226-AlaArgLeuGluLysArgPheAspArgTyrValAla-237 Hydrophilic Regions - Hopp-Woods 13-ThrGluThrArgAlaAspMet-19 193-AlaGlnGluThrAlaAsnArgThr-200 226-AlaArgLeuGluLysArgPheAspArgTyrValAla-237 g706 AMPHI Regions - AMPHI H-GlyArgTrpLeuAsnSerTyr-17 24-ArgLeuIleHisAlaValArg-30 39-ThrAlaLeuAlaArgLeuLeuHis-46 70-IleTyrSerAsnAlaValGluArgMetLeuGlyThrValIleGly-84 Hl-ThrAlaSerAlaLeuAlaGlyTrpAlaAla-120 153-ArgAlaMetAsnValLeu-158 183-LeuAlaAspAsnLeuAlaAspCysSerLysMetIleAlaGluIleSerAsnGlyArg-201 241-SerMetMetGluAlaMetGlnHisAlaHisArgLysIleVal-254 318-AlaLeuAlaGluHisLeuHis-324 Antigenic Index - Jameson-Wolf 1-MetAsnSerSerGlnArgLysArgLeuSerGlyArgTrpLeuAsnSerTyrGluArgTyrArgHisArgArgLe u-25 3O-ArgLeuGlyGlyThr-34 71-TyrSerAsnAlaValGluArgMetLeu-79 97-HisTyrPheHisGlyAsnLeu-103 122-GlyLysAsnGlyTyrVal-127 140-GlyAspAsnGlySerGluTrpLeuAsp-148 186-AsnLeuAlaAspCysSerLysMetIleAlaGluIleSerAsnGlyArgArgMetThrArgGluArgLeuGlu GlnAsnMetValLysMetArgGlnIleAsn-219 221-ArgMetValLysSerArgSerHisLeuAlaAlaThrSerGlyGluSerArgIleSerProSerMet-242 249-AlaHisArgLysIleValAsn-255 266-LysLeuGlnSerProLysLeuAsnGlySerGluIleArgLeuLeuAsp-281 289-ThrAspLeuGlnGln-293 300-GlyArgHisAlaArgArgIleArgIleAspThrAlaIleAsnProGluLeuGluAlaLeuAla-320 334-SerThrAsnMetArgGlnGluIle-341 349-GlnArgThrArgArgLysTrpLeuAspAlaHisGluArgGlnHisLeu-364 367-SerLeuLeuGluThrArgGluHisGly-375 Hydrophilic Regions - Hopp-Woods 3-SerSerGlnArgLysArgLeuSer-10 17-TyrGluArgTyrArgHisArgArgLeu-25 74-AlaValGluArgMetLeu-79 142-AsnGlySerGluTrpLeu-147 186-AsnLeuAlaAspCysSerLysMetIleAla-195 198-SerAsnGlyArgArgMetThrArgGluArgLeuGluGlnAsnMetValLysMetArgGlnIleAsn-219 221-ArgMetValLysSerArgSerHis-228 232-ThrSerGlyGluSerArgIleSer-239 249-AlaHisArgLysIleValAsn-255 266-LysLeuGlnSerProLysLeuAsnGlySerGluIleArgLeuLeuAsp-281 301-ArgHisAlaArgArgIleArgIle-308 314-ProGluLeuGluAlaLeuAla-320 336-AsnMetArgGlnGluIle-341 349-GlnArgThrArgArgLysTrpLeuAspAlaHisGluArgGlnHisLeu-364 367-SerLeuLeuGluThrArgGluHisGly-375 g707 AMPHI Regions - AMPHI 36-GlyIleGluLysMetAlaThrGln-43 91-HisAlaGlyAspIleAsnGlnIleMetSerLeu-101 116-IleLeuAlaAlaPro-120 134-ProGlyTyrLeuArgSerIleArgIle-142 168-AspLeuLeuAsnLeuArgAsp-174 182-LeuLysCysLeuPro-186 208-ValGlnTrpArgArgLeuLeuPro-215 248-SerAspMetPheTyr-252 256-GlyArgSerIleGlyGly-261 301-ArgTyrHisGlnAlaValSerGlyLeuSerGluValTyrAsp-314 368-TrpLeuAlaGluLeuSerHis-374 393-ThrGlyMetLysAspAlaLeuArgAlaProGluGluAlaPheGlyGluGly-409 440-HisAlaGlnTrpAsnLys-445 542-LeuLysLysProGluTyrPhe-548 Antigenic Index - Jameson-Wolf 1-GluAlaValSerGlnGlnGlnAspIleLeuGlnArgGlnArgGluLysGlnLeuArgGluGlnMetGlnProGl uGlnAspValArgLeuAspGlyThrAspThrGlyIleGluLysMetAla-41 44-ValGlyGlyAlaAsnSerAspGluAlaSerProCys-55 62-GluLeuValGlyGluGluAlaAlaLys-70 120-ProGlnAspLeuAsnSerGlyLysLeu-128 140-IleArgIleAspArgSerAsnAspAspGlnThrHis-151 160-AsnLysPheProThrArgSerAsnAspLeuLeuAsn-171 173-ArgAspLeuGluGlnGlyLeuGluAsn-181 188-AlaGluAlaAspLeu-192 196-ProValGluArgGluProAsnGlnSerAsp-205 221-GlyMetAspAsnSerGlySerGluAlaThrGlyLysTyrGlnGly-235 241-AlaAspAsnProPheGlyLeu-247 255-TyrGlyArgSerIleGlyGlyThrProAspGluGluAsnPheAspGlyHisArgLysGluGlyGlySerAsn -278 297-HisAsnGlyTyrArg-301 311-GluValTyrAspTyrAsnGlyLysSerTyrAsnThrAspPheGlyPhe-326 330-LeuTyrArgAspAlaLysArgLysThrTyrLeu-340 345-TrpThrArgGluThrLysSerTyrIleAspAspAlaGluLeuThrValGlnArgArgLysThrThr-366 372-LeuSerHisLysGlyTyrIleGlyArgSerThrAlaAspPheLysLeuLysTyrLysHisGlyThrGlyMet LysAspAlaLeuArgAlaProGluGluAlaPheGlyGluGlyThrSerArg-412 419-SerAlaAspValAsnThrPro-425 442-GlnTrpAsnLysThrProLeuThrSerGlnAspLysLeuAla-455 460-HisThrValArgGlyPheAspGlyGluMetSerLeuProAlaGluArgGlyTrpTyrTrpArgAsnAspLeu SerTrpGlnPheLysProGlyHis-491 503-SerGlyGlnSerAlaLys-508 540-ArgAlaLeuLysLysProGluTyrPheGlnThrLysLysTrpValThr-555 Hydrophilic Regions - Hopp-Woods 1-GluAlaValSerGlnGlnGlnAspIleLeuGlnArgGlnArgGluLysGlnLeuArgGluGlnMetGlnProGl uGlnAspValArgLeuAspGlyThrAspThrGlyIleGluLysMetAla-41 47-AlaAsnSerAspGluAlaSer-53 62-GluLeuValGlyGluGluAlaAlaLys-70 121-GlnAspLeuAsnSerGlyLys-127 140-11eArglleAspArgSerAsnAspAspGlnThrHis-151 162-PheProThrArgSerAsnAsp-168 173-ArgAspLeuGluGlnGlyLeuGluAsn-181 188-AlaGluAlaAspLeu-192 196-ProValGluArgGluProAsnGlnSer-204 222-MetAspAsnSerGlySerGluAlaThrGlyLysTyr-233 259-IleGlyGlyThrProAspGluGluAsnPheAspGlyHisArgLysGluGlyGlySer-277 313 -TyrAspTyrAsnGly-317 330-LeuTyrArgAspAlaLysArgLysThrTyrLeu-340 345-TrpThrArgGluThrLysSerTyrIleAspAspAlaGluLeuThrValGlnArgArgLysThrThr-366 381-SerThrAlaAspPheLysLeuLysTyrLysHis-391 393-ThrGlyMetLysAspAlaLeuArgAlaProGluGluAlaPheGly-407 447-ProLeuThrSerGlnAspLysLeuAla-455 463-ArgGlyPheAspGlyGluMet-469 540-ArgAlaLeuLysLysProGluTyrPheGln-549 g708 AMPHI Regions - AMPHI 26-ProSerArgAlaGluLysAlaAsnGlnValSerAsnIle-38 56-ThrAlaSerIleGluAspAlaLeuLysSerAsnPro-67 79-IleTyrGlnTyrLeuLys-84 89-AlaGlnGluSerPhe-93 119-AsnArgProAlaGluSerMetAla-126 128-PheAspLysAlaLeu-132 142-IleAlaAsnLeuAsnLys-147 176-ProAlaPheLysGluLeuAlaArg-183 221-LysAlaLeuGlyAsnValGlnAla-228 Antigenic Index - Jameson-Wolf 2-ProPheLysProSerLysArgIleSer-10 19-AlaCysSerThrSerTyrArgProSerArgAlaGluLysAlaAsnGln-34 46-TyrMetArgGlyGlnAspTyrArgGlnAlaThrAlaSerIleGluAspAlaLeuLysSerAsnProLysAsnG luLeu-71 84-LysValAsnAspLysAlaGlnGluSerPheArg-94 97-LeuSerIleLysProAspSerAlaGluIleAsnAsnAsnTyrGlyTrp-112 115-CysGlyArgLeuAsnArgProAlaGlu-123 131-AlaLeuAlaAspProThrTyrProThr-139 145-LeuAsnLysGlyIleCysSerAlaLysGlnGlyGln-156 176-ProAlaPheLysGluLeuAlaArgThrLysMet-186 191-LeuGlyAspAlaAspTyrTyrPheLysLysTyrGlnSerArgValGluValLeuGlnAlaAspAspLeu-21 3 240-PheProTyrSerGluGluLeuGln-247 Hydrophilic Regions - Hopp-Woods 4-LysProSerLysArgIle-9 24-TyrArgProSerArgAlaGluLysAlaAsnGln-34 46-TyrMetArgGlyGlnAspTyrArgGln-54 56-ThrAlaSerIleGluAspAlaLeuLysSerAsnProLysAsnGlu-70 84-LysValAsnAspLysAlaGlnGluSerPheArg-94 99-IleLysProAspSerAlaGluIle-106 117-ArgLeuAsnArgProAlaGlu-123 149-IleCysSerAlaLysGlnGly-155 177-AlaPheLysGluLeuAlaArgThrLysMet-186 201-TyrGlnSerArgValGluValLeuGlnAlaAspAspLeu-213 g709 AMPHI Regions - AMPHI 6-SerLeuLeuAspMetProArgGlyGlu-14 18-ValValValAlaLeuIleAlaAlaMetGly-27 37-ProHisMetSerIleIleAlaAlaIleValValLeu-48 54-AlaArgGlyLeuLysTyr-59 67-IleGlyAlaLeuAsnGlnGlyMet-74 115-SerAlaPheAlaLeuCysSerVal-122 130-SerLeuThrAlaCysAla-135 171-ProLeuSerAspThr-175 185-1leAspLeuPheGluHis11eLysAsnMetMetTyrThrThr-198 221-LeuAsnSerValGluSerPheArg-228 245-PheAlaLeuLeuValValLeu-251 261-AlaMetLeuPheThrValIleAlaAlaValAlaValThrTyr-274 278-ThrProAspLeuArgGlnLeuGlyAlaTrpPhe-288 298-AlaPheLysAspIleAlaLysLeuIleSerArgGlyGly-310 334-LeuGlyValIleProSerLeuLeuGluAlaValArgThrPheLeuThr-349 382-ThrPheLysProVal-386 396-AsnLeuSerArgThrLeuGluAspAlaGlyThrValIleAsnProLeuValProTrpSerValCysGlyVal PheIleSerHis-423 Antigenic Index - Jameson-Wolf 8-LeuAspMetProArgGlyGluAla-15 55-ArgGlyLeuLysTyrAsnAspMetGln-63 165-PheGlyAspLysMetSerProLeuSerAspThrThrGly-177 222-AsnSerValGluSerPheArgSerGlnLeuGlu-232 277-SerThrProAspLeuArgGln-283 290-GlyGlyTyrLysLeuGluGlyGluAlaPheLysAspIleAlaLysLeuIleSerArgGlyGlyLeuGlu-31 2 349-ThrAsnAlaGlyArgAlaThr-355 378-LeuSerGlyGluThrPheLysProValTyrAspLysLeuGly-391 396-AsnLeuSerArgThrLeuGluAspAlaGlyThr-406 Hydrophilic Regions - Hopp-Woods 8-LeuAspMetProArgGlyGluAla-15 57-LeuLysTyrAsnAsp-61 167-AspLysMetSerProLeuSerAsp-174 225-GluSerPheArgSerGlnLeuGlu-232 279-ProAspLeuArgGln-283 293-LysLeuGluGlyGluAlaPheLysAspIleAlaLysLeuIleSer-307 399-ArgThrLeuGluAspAlaGly-405 g716 AMPHI Regions - AMPHI 33-GlyValGlnLysSerAlaGlnGly-40 81-AlaThrValLysLysAlaHisLysHisThrLysAla-92 Antigenic Index - Jameson-Wolf l-Me AsnLysAsnIle-5 26-LysProAlaSerAsnAlaThrGlyValGlnLysSerAlaGlnGlySerCysGlyAlaSerLysSerAlaGluG lySerCysGlyAlaSerLysSerAlaGluGlySerCysGly-63 65-AlaAlaSerLysAlaGlyGluGlyLysCysGlyGluGlyLysCysGlyAlaThrValLysLysAlaHisLysH isThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysGlyGluGlyLysCysGlySerLys-112 Hydrophilic Regions - Hopp-Woods 33 -GlyValGlnLysSerAlaGln-39 43-GlyAlaSerLysSerAlaGluGlySerCysGlyAlaSerLysSerAlaGluGlySerCys-62 65-AlaAlaSerLysAlaGlyGluGlyLysCysGlyGluGlyLysCys-79 81-AlaThrValLysLysAlaHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysG lyGluGlyLysCysGlySerLys-112 g717 AMPHI Regions - AMPHI 87-AlaAlaIleAlaAla-91 174-ThrAlaValTyrAlaLeuAlaAsn-181 209-LeuHisArgGlyLeu-213 223-SerLeuAlaTyrTrp-227 241-AlaGlyLeuGluGlnLeuGly-247 263-GlnSerIlePheSerThrValTrpThrProTyrIlePheArgAlaIleGluGlu-280 305-ThrGlyIlePheSerProLeuAlaSer-313 347-LeuAsnValValArgLysThr-353 358-LeuAlaThrLeuGlyAlaLeuAla-365 401-SerSerCysArgLeuTrpGlnProLeuLysArgLeu-412 430-CysPheGlyThrPro-434 442-GlyValTrpAlaAlaTyrLeuAlaGly-450 457-LysAsnLeuHisLysLeuPheHisTyr-465 Antigenic Index - Jameson-Wolf 1-MetAspThrLysGlu-5 32-ProAlaAspAspIleGlyArg-38 69-AlaAspLysAspThrLeu-74 95-SerArgProSerLeuProSerGluIle-103 135-MetGluGlyArgAla-139 192-AsnArgCysArgLeuLysAlaValArgArgAlaProPheSer-205 231-SerAlaAspArgLeuPheLeu-237 277-AlaIleGluGluAsnAlaThrProAlaArgLeu-287 289-AlaThrAlaGluSer-293 317-ProGluAsnTyrAla-321 349-ValValArgLysThrArgProIleAla-357 376-ProSerGlyGlyThrArgGlyAla-383 398-LysThrGluSerSerCysArgLeu-405 453-LeuArgHisArgLysAsnLeu-459 Hydrophilic Regions - Hopp-Woods 1-MetAspThrLysGlu-5 69-AlaAspLysAspThrLeu-74 135-MetGluGlyArgAla-139 192-AsnArgCysArgLeuLysAlaValArgArgAlaPro-203 277-AlaIleGluGluAsnAlaThrProAlaArgLeu-287 289-AlaThrAlaGluSer-293 349-ValValArgLysThrArgPro-355 378-GlyGlyThrArgGly-382 399-ThrGluSerSerCys-403 453-LeuArgHisArgLysAsnLeu-459 g728 AMPHI Regions - AMPHI H-SerPhePheAlaLeuValPheAla-18 39-AlaThrGluValProGluAsnPro-46 48-AlaPheValAlaLysLeuAlaArgLeuPheArgAsnAla-60 74-GluGluSerLeuAlaGlyAlaValAspAsp-83 167-HisGlyGluAsnTyrGluThr-173 198-GluAspValTyrGluHisCysLeuGlyCysTyrGlnMet-210 218-TyrArgAspValAlaAsn-223 235-SerAsnArgIleAlaSer-240 251-MetArgGluLeuMetProArg-257 355-GluLysGluValSerArgTyrAlaGluAlaAlaAlaArg-367 Antigenic Index - Jameson-Wolf 29-IleAsnProArgTrp-33 35-LeuSerAspThrAlaThrGluValProGluAsnProAsnAla-48 57-PheArgAsnAlaAspArgAla-63 67-ValLysGluSerMetArgThrGluGluSerLeu-77 80-AlaValAspAspGlyProLeuGlnSerGluLysAspTyr-92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyGlu-118 125-TyrIleGlyGluGlyGly-130 136-LeuSerGlnArgSerProGluAlaPheVal-145 149-TyrLeuTyrArgAsnAspArgProPheSer-158 166-AlaHisGlyGluAsnTyrGluThrThrGlyGluTyrArgVal-179 182-GlnProAspGlySerVal-187 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgGluGluSerAsnArgIleAlaSer AspSerArgAspTyrVal-246 250-AsnMetArgGluLeuMetProArgGlyMetLysAlaAsnSer-263 267-GlyTyrAspAlaAspGlyLeuProGlnLys-276 280-SerPheAspAsnGlyLysLysArgGlnSerPheGluTyrTyrLeuLysAsnGlyAsn-298 309-LeuLysAlaAspGlyValThr-315 329-LeuAspGlyGlyArgIleIleArgGluGluLysGlnGlyAspArgLeuProAspPhe-347 349-LeuAsnLeuGluAspLeuGluLysGluValSerArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArg ArgGlyLeuSerHis-377 Hydrophilic Regions - Hopp-Woods 38-ThrAlaThrGluValProGluAsnPro-46 57-PheArgAsnAlaAspArgAla-63 67-ValLysGluSerMetArgThrGluGluSerLeu-77 80-AlaValAspAspGlyProLeuGlnSerGluLysAspTyr-92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyGlu-118 136-LeuSerGlnArgSerProGlu-142 151-TyrArgAsnAspArgProPhe-157 169-GluAsnTyrGluThrThrGlyGluTyr-177 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgGluGluSerAsnArgIleAlaSerA spSerArgAsp-244 250-AsnMetArgGluLeuMetProArgGlyMetLys-260 268-TyrAspAlaAspGlyLeuPro-274 282-AspAsnGlyLysLysArgGlnSer-289 309-LeuLysAlaAspGlyValThr-315 331-GlyGlyArgIleIleArgGluGluLysGlnGlyAspArgLeuPro-345 349-LeuAsnLeuGluAspLeuGluLysGluValSerArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArg ArgGlyLeuSer-376 g729 AMPHI Regions - AMPHI 21-CysThrMetIleProGlnTyr-27 55-HisAspTyrPheAla-59 61-ProArgLeuGlnLysLeuIleAspIle-69 149-GlnGlyTyrPheAla-153 242-LeuAlaThrLeuIleAsn-247 250-IleProGluAspLeuProAla-256 268-LysLeuProAlaGlyLeu-273 321-GluLeuGlyGlyLeuPheLysSerGly-329 371-ValGlnSerAlaPheGlnAspValAlaAsnAla-381 388-LeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArg-400 419-GlyAlaLeuAspLeuLeuAspAlaGlu-427 442-LeuThrArgAlaGluAsnLeuAlaAspLeuTyrLysAlaLeuAspGlyGlyLeu-459 Antigenic Index - Jameson-Wolf 25-ProGlnTyrGluGlnProLysValGluVal-34 36-GluThrPheGlnAsnAspThrSerValSerSer-46 53-GlyTrpHisAspTyrPheAlaAspProArgLeuGlnLys-65 70-AlaLeuGluArgAsnThrSerLeuArgThr-79 85-GluIleTyrArgLysGlnTyrMetIleGluArgAsnAsnLeuLeuPro-100 106-AlaAsnGlySerArgGlnGlySerLeuSerGlyGlyAsnValSerSerSerTyrAsn-124 138-GlyArgValArgSerAsnSerGluAlaAla-147 156-AlaAsnArgAspAlaAla-161 173-TyrPheAsnGluArgTyrAlaGluLysAlaMet-183 188-ArgValLeuLysThrArgGluGluThrTyrLysLeuSerGluLeuArgTyr-204 215-ArgGlnGlnGluAlaLeuIleGluSerAlaLysAlaAspTyr-228 232-AlaArgSerArgGluGlnAlaArgAsn-240 247-AsnArgProIleProGluAspLeuProAla-256 277-ValLeuLeuAspArgProAspIleArgAlaAlaGluHisAlaLeuLysGlnAlaAsnAla-296 310-ArgLeuThrGlySerValGlyThrGlySer-319 326-PheLysSerGlyThr-330 347-GlyThrAsnLysAlaAsnLeuAspValAlaLysLeuArgGlnGln-361 383-AlaAlaArgGluGlnLeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArgAlaSerLysGluAlaLeu Arg-407 411-LeuArgTyrLysHisGlyValSer-418 424-LeuAspAlaGluArgIleSerTyrSerAlaGluGly-435 442-LeuThrArgAlaGluAsnLeu-448 455-LeuAspGlyGlyLeuLysArgAspThrGlnThrGlyLys-467 Hydrophilic Regions - Hopp-Woods 28-GluGlnProLysValGluVal-34 42-ThrSerValSerSer-46 61-ProArgLeuGlnLys-65 70-AlaLeuGluArgAsnThrSerLeu-77 91-TyrMetIleGluArgAsnAsn-97 107-AsnGlySerArgGlnGlySer-113 138-GlyArgValArgSerAsnSerGluAlaAla-147 156-AlaAsnArgAspAlaAla-161 177-ArgTyrAlaGluLysAlaMet-183 188-ArgValLeuLysThrArgGluGluThrTyrLys-198 200-SerGluLeuArgTyr-204 215-ArgGlnGlnGluAlaLeuIleGluSerAlaLysAlaAspTyr-228 232-AlaArgSerArgGluGlnAlaArgAsn-240 249-ProIleProGluAspLeuPro-255 277-ValLeuLeuAspArgProAspIleArgAlaAlaGluHisAlaLeuLysGlnAlaAsn-295 350-LysAlaAsnLeuAspValAlaLysLeuArgGln-360 383-AlaAlaArgGluGlnLeuAspLysAlaTyrAspAlaLeuSerLysGlnSerArgAlaSerLysGluAlaLeu Arg-407 424-LeuAspAlaGluArgIleSerTyr-431 442-LeuThrArgAlaGluAsnLeu-448 455-LeuAspGlyGlyLeuLysArgAspThrGlnThrGlyLys-467 g730 AMPHI Regions - AMPHI 6-ArgLeuThrAsnLeuLeuAlaAlaCysAla-15 26-LeuAlaAlaAspLeu-30 67-LysIleAsnValIleGlnAspTyrThrHisGln-77 lll-AsnHisAlaAlaAsp-115 141-HisProAlaAspAlaTyrAspGlyProLysGlyGlyAsnTyrProLysProThr-158 187-GlnArgIlePheAspAsnTyrAsnAsnLeuGlySerAsnPheSerAspArgAlaAspGlu-206 214-HisAsnAlaLysLeu-218 220-ArgTrpGlyAsnSerMetGluPheValAsnGlyValAla-232 234-GlyAlaLeuAsnProPheIleSer-241 262-AlaAlaMetArgAsnIleAla-268 277-AlaAlaIleGlyGlyLeuGlySerAla-285 288-PheGluLysAsnThrArgGluAlaValAspArgTrpIleGlnGlu-302 305-AsnAlaAlaGluThrValGluAlaLeuValAsnValLeuProPheAlaLysValLysAsnLeuThrLysAla AlaLysPro-331 353-LeuValLysThrAlaAspGlyTyrLysAlaIleAlaHisIleGlnAla-368 390-ArgTyrGlyAsnProTyr-395 403-ValSerAspGlyIle-407 434-LysAlaGlySerArgLeuLeuSerGluSer-443 458-ProLeuLysAlaTyr-462 510-AspSerHisArgSerValGlyAspSerAsnArgValValArgGluGlyLys-526 553-GlnValThrGlnPheLys-558 Antigenic Index - Jameson-Wolf 2-LysProLeuArgArgLeuThr-8 35-Phel1eThrAspAsnThrGlnArgGlnHisTyrGluProGlyGlyLys-50 55-GlyAspP oArgGlySerValSerAspArgThrGlyLys11eAsnVal-70 99-SerGlyHisGlyHisGluGluHisAlaProPheAsp-110 112-HisAlaAlaAspSerAlaSerGluGluLysGlyAsnValAspAspGlyPhe-128 133-LeuAsnTrpGluGlyHisGluHisHisProAlaAspAlaTyrAspGlyProLysGlyGlyAsnTyrProLys ProThrGlyAlaArgAspGluTyrThrTyrHisVal-168 170-GlyThrAlaArgSerIleLysLeuAsnProThrAspThrArgSerIleArgGlnArgIle-189 191-AspAsnTyrAsnAsnLeuGlySerAsnPheSerAspArgAlaAspGluAlaAsnArgLysMetPheGluHis AsnAlaLysLeuAspArgTrpGlyAsnSer-224 257-TyrAlaIleAspLysAlaAlaMet-264 271-ProAlaGluGlyLysPhe-276 287-GlyPheGluLysAsnThrArgGluAlaValAsp-297 299-TrpIleGlnGluAsnProAsnAlaAlaGluThrValGlu-311 323-LysAsnLeuThrLysAlaAlaLysProGlyLysAlaAlaValSerGlyAspPheSerLysSerTyr-344 355-LysThrAlaAspGlyTyrLys-361 367-GlnAlaGlyAspArgValLeuSerLysAspGluAlaSerGlyGluThrGlyTyrLysProValThrAlaArg TyrGlyAsnProTyrGlnGlu-397 403-ValSerAspGlyIleGlyAsnSer-410 422-TyrSerAspGlyLysTrpIleLysAlaGluAspLeuLysAlaGlySerArgLeuLeuSerGluSerGlyLys ThrGlnThr-448 453-ValValLysProLysProLeuLys-460 474-ValLysGlyAsnGlnAlaGluThrGlu-482 487-HisAsnAspCysProProLysProLysProThrAsnHisAlaGlnGlnArgLysGluGluAlaLysAsnAsp SerHisArgSerValGlyAspSerAsnArgValValArgGluGlyLysGlnTyrLeuAspSerAspThrGlyAsn- 535 538-TyrValLysGlyAspLysVal-544 547-LeuThrProAspGlyArgGlnValThrGlnPheLysAsnSerLysAlaAsnThrSerLysArgValLysAsn GlyLysTrpThrProLys-576 Hydrophilic Regions - Hopp-Woods 2-LysProLeuArgArgLeuThr-8 39-AsnThrGlnArgGlnHisTyrGluProGlyGly-49 55-GlyAspProArgGlySerValSerAspArgThrGlyLys-67 102-GlyHisGluGluHisAlaPro-108 112-HisAlaAlaAspSerAlaSerGluGluLysGlyAsnValAspAspGly-127 135-TrpGluGlyHisGluHisHisPro-142 144-AspAlaTyrAspGlyProLysGlyGlyAsnTyrProLys-156 158-ThrGlyAlaArgAspGluTyr-164 170-GlyThrAlaArgSerIleLys-176 178-AsnProThrAspThrArgSerIleArgGlnArgl1e-189 200-PheSerAspArgAlaAspGluAlaAsnArgLysMetPheGluHisAsnAlaLysLeuAspArgTrpGlyAsn -223 257-TyrAlaIleAspLysAlaAlaMet-264 271-ProAlaGluGlyLysPhe-276 287-GlyPheGluLysAsnThrArgGluAlaValAsp-297 303 -AsnProAsnAlaAlaGluThrValGlu-311 323-LysAsnLeuThrLysAlaAlaLysProGlyLysAlaAlaVal-336 355-LysThrAlaAspGlyTyrLys-361 368-AlaGlyAspArgValLeuSerLysAspGluAlaSerGlyGluThrGlyTyr-384 403-ValSerAspGlyIleGly-408 426-LysTrpIleLysAlaGluAspLeuLysAlaGlySer-437 439-LeuLeuSerGluSerGlyLysThrGlnThr-448 453-ValValLysProLysProLeuLys-460 477-AsnGlnAlaGluThrGlu-482 489-AspCysProProLysProLysProThrAsn-498 500-AlaGlnGlnArgLysGluGluAlaLysAsnAspSerHisArgSerValGlyAspSerAsnArgValValArg GluGlyLysGlnTyrLeuAspSerAspThrGly-534 539-ValLysGlyAspLys-543 549-ProAspGlyArgGln-553 558-LysAsnSerLysAlaAsnThrSerLysArgValLysAsnGlyLysTrpThrPro-575 g731 AMPHI Regions - AMPHI 17-AlaCysAlaValProGluAlaTyrAspGlyGly-27 40-GlyProAspAspPheArgAlaPheSerCys-49 Antigenic Index - Jameson-Wolf 22-GluAlaTyrAspGlyGlyGlyArgGlyTyr-31 33-ProProValGlnAsnGlnAlaGlyProAspAspPheArgAla-46 48-SerCysGluAsnGlyLeu-53 55-ValArgValArgAsnLeuAspGlyGlyLysIleAlaLeuArgLeuAspGlyArgArgAlaValLeuSerSerA spValAlaAlaSerGlyGluArgTyrThrAla-89 92-GlyLeuPheGlyAsnGlyThrGluTrpHisGlnLysGlyGlyGluAla-107 113-AspAlaTyrGlyAsnSerValGluThrSerCysArgAlaArg-126 Hydrophilic Regions - Hopp-Woods 22-GluAlaTyrAspGlyGlyGly-28 39-AlaGlyProAspAspPheArg-45 55-ValArgValArgAsnLeuAspGlyGlyLysIleAlaLeuArgLeuAspGlyArgArgAlaValLeu-76 80-ValAlaAlaSerGlyGluArgTyrThrAla-89 100-TrpHisGlnLysGlyGlyGlu-106 119-ValGluThrSerCysArgAlaArg-126 g732 AMPHI Regions - AMPHI 14-LeuGlyAlaIleSer-18 43-ValGlnSerIleArgThrMetAlaGluValTyrGly-54 66-AspAlaAspLeuPheGluGlyAlaMetLysGlyMetVal-78 95-GluIleLysGluSerThrSerGly-102 115-AspGlyPheValLysValValΞerProIleGluAsp-126 155-GluAlaValLysLysMet-160 183-ValAsnLeuThrArg-187 214-GluArgThrValGluSerValAsnThrAlaAlaLys-225 283-LysAlaValProGluAspTyrValTyr-291 293-MetGlyGlyAspProLeuAlaGlyIleProAlaGluLeu-305 322-SerGluIleValAlaGly-327 400-LeuValGlyHisIleGlyAsn-406 446-ArgArgIleProAsnProAlaLysAsp-454 459-LysAlaLeuAspLeuValLysSerProGluGlnTrpGlnLysSerLeu-474 Antigenic Index - Jameson-Wolf 30-AlaAlaGluLysAspGlyArgAspAsnGluVal-40 59-AsnTyrTyrHisAspLysProAspAlaAspLeuPhe-70 82-AspProHisSerGluTyrMetAspLysLysGlyTyrAlaGluIleLysGluSerThrSerGlyGluPheGlyG ly-106 lll-IleGlyGlnGluAspGlyPhe-117 122-SerProIleGluAspThrProAlaGluArgAlaGluValLysSerGlyAspPhe-139 144-AspAsnValSerThrArgGlyMetThr-152 155-GluAlaValLysLysMetArgGlyLysProGlyThrLysIle-168 172-LeuSerArgLysAsnAlaAspLysProIle-181 199-LeuIleGluProAspTyrGlyTyr-206 211-GlnPheGlnGluArgThrValGlu-218 221-AsnThrAlaAlaLysGluLeuValLysGluAsnLysGlyLysProLeuLys-237 242-AspLeuArgAspAspProGlyGlyLeu-250 269-ValSerThrLysGlyArgAspGlyLysAspGlyMetVal-281 284-AlaValProGluAspTyr-289 293-MetGlyGlyAspPro-297 303-AlaGluLeuLysThr-307 316-SerGlySerAlaSerAla-321 330-GlnAspHisLysArgAlaVal-336 340-ThrGlnSerPheGlyLysGlySerVal-348 354-LeuSerAsnGlySer-358 368-TyrThrProAsnAspArgSerIleGln-376 384-ValGluValLysAspLysGluArgThrPheGluSerArgGluAlaAspLeu-400 405-GlyAsnProLeuGlyGlyGluAspValAsnSerGlu-416 421-ProLeuGluLysAspAlaAspLysProAlaAlaLysGluLysGlyLysLysLysLysAspGluAspLeuSer SerArgArglleProAsnProAlaLysAspAspGlnLeuArgLysAlaLeuAspLeuValLysSerProGluGlnT rpGlnLys-472 477-AlaAlaLysLysProValSerAsnLysAspLysLysAspLysLys-491 Hydrophilic Regions - Hopp-Woods 30-AlaAlaGluLysAspGlyArgAspAsnGluVal-40 60-TyrTyrHisAspLysProAspAlaAspLeuPhe-70 82-AspProHisSerGluTyrMetAspLysLysGlyTyrAlaGluIleLysGluSerThrSerGlyGlu-103 lll-IleGlyGlnGluAspGlyPhe-117 122-SerProIleGluAspThrProAlaGluArgAlaGluValLysSerGlyAspPhe-139 144-AspAsnValSerThr-148 155-GluAlaValLysLysMetArgGlyLysProGlyThr-166 172-LeuSerArgLysAsnAlaAspLysProIle-181 211-GlnPheGlnGluArgThrValGlu-218 221-AsnThrAlaAlaLysGluLeuValLysGluAsnLysGlyLysProLeuLys-237 242-AspLeuArgAspAspProGly-248 271-ThrLysGlyArgAspGlyLysAspGlyMetVal-281 303 -AlaGluLeuLysThr-307 330-GlnAspHisLysArgAlaVal-336 370-ProAsnAspArgSerIleGln-376 384-ValGluValLysAspLysGluArgThrPheGluSerArgGluAlaAspLeu-400 408-LeuGlyGlyGluAspValAsnSer-415 421-ProLeuGluLysAspAlaAspLysProAlaAlaLysGluLysGlyLysLysLysLysAspGluAspLeuSer SerArgArglleProAsnProAlaLysAspAspGlnLeuArgLysAlaLeuAspLeuValLysSerProGluGlnT rpGln-471 477-AlaAlaLysLysProValSerAsnLysAspLysLysAspLysLys-491 g733 AMPHI Regions - AMPHI 6-ThrLeuGlyArgLeuSer-11 16-ValLeuAlaLeuThrAla-21 33-TyrGlyGlyTyrProAspThrValTyrGluGly-43 53-LysGlnThrGluLysMetGluLysTyrPheAlaGluAlaAlaAsn-67 92-GlyAlaPheArgGlnPheGluGlu-99 Antigenic Index - Jameson-Wolf 2-MetAsnProLysThrLeuGly-8 23-AlaGlyGlyGlyHisLys-28 32-TyrTyrGlyGlyTyrProAspThrValTyrGluGlyLeuLysAsnAspAspThrSerLeuGlyLysGlnThrG luLysMetGluLysTyrPhe-62 65-AlaAlaAsnLysLysMetAsnAlaAlaProGlyAla-76 84-LeuSerArgSerGlyAspLysGluGlyAlaPheArgGlnPheGluGluGluLysArgLeuPheProGlu-106 115-MetLysThrGlyLysGlyGlyLysArg-123 Hydrophilic Regions - Hopp-Woods 40-ValTyrGluGlyLeuLysAsnAspAspThrSerLeuGlyLysGlnThrGluLysMetGluLysTyrPhe-62 65-AlaAlaAsnLysLysMetAsnAla-72 86-ArgSerGlyAspLysGluGlyAlaPheArgGlnPheGluGluGluLysArgLeuPhePro-105 115-MetLysThrGlyLysGlyGlyLysArg-123 g734 AMPHI Regions - AMPHI 26-TyrLeuAlaValTrpGlnAsnProGlnAspAlaAsnAspValLeuGlnVal-42 53-GluAlaPheAlaGluLeuGluAlaPheCysLys-63 77-ThrGlyCysArgSerValValSer-84 92-LeuAlaTyrProLysAlaLeuGlyAlaMetArg-102 113-ArgPheThrSerVal-117 121-AlaLeuAsnGlnCysIleLysLys-128 Antigenic Index - Jameson-Wolf 31-GlnAsnProGlnAspAlaAsnAspValLeuGln-41 43-LysThrThrLysGluAspSerAlaLysSerGluAlaPheAlaGlu-57 60-AlaPheCysLysGlyGlnAspThr-67 71-IleAlaGluAspGluProThrGlyCysArgSer-81 101-MetArgValGluAsn-105 lll-SerProArgPheThrSer-116 125-CysIleLysLysTyrGlyAlaGlnGly-133 145-SerSerTyrTyrGly-149 Hydrophilic Regions - Hopp-Woods 34-GlnAspAlaAsnAsp-38 43-LysThrThrLysGluAspSerAlaLysSerGluAlaPheAlaGlu-57 60-AlaPheCysLysGlyGlnAspThr-67 71-IleAlaGluAspGluProThrGlyCys-79 101-MetArgValGluAsn-105 125-CysIleLysLysTyrGlyAla-131 g736 AMPHI Regions - AMPHI 13-GlyLeuIleGlnSerPheGlySer-20 50-GlyValLeuSerVal-54 61-GlyLeuPheValGly-65 70-LeuGlnGlyTyrThrGlnLeuSerLysPheLysSerAlaAspIle-84 93-LeuLeuArgGluLeuGlyProVal-100 120-LeuMetLysThrThrGlyGlnLeuGluAlaMetAsnValMet-133 135-ValAsnProValAlaArgValVal-142 144-ProArgPheTrpAlaGlyValPheSerMetPro-154 156-LeuAlaSerIlePheAsnValAlaGlyIlePheGlyAla-168 196-AspValIleAsnGlyLeu-201 230-LeuArgAlaSerThrArgThr-236 Antigenic Index - Jameson-Wolf 30-AlaLysSerGlyThrAlaPheAlaArgProArgLeuSerVal-43 77-SerLysPheLysSer-81 93-LeuLeuArgGluLeuGly-98 109-SerAlaGlyGlyAlaMetThrSer-116 186-GlnMetGlnAsnAsn-190 224-ProThrSerGluGlyIleLeuArgAlaSerThr-234 Hydrophilic Regions - Hopp-Woods 37-AlaArgProArgLeuSerVal-43 77-SerLysPheLysSer-81 93 -LeuLeuArgGluLeuGly-98 g737 AMPHI Regions - AMPHI 56-AlaAlaTrpAlaArgValGlyGly-63 Antigenic Index - Jameson-Wolf 24-AlaHisHisAspGlyHisGlyAspAspAspHisGlyHis-36 38-AlaHisGlnHisGlyLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAla-57 60-ArgValGlyGlyLysIleThrAspIleAspLeuGluHisAspAspGlyArgProHisTyrAspValGluIleV alLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArgValIleSerSerArgArgAspAsp-108 Hydrophilic Regions - Hopp-Woods 27-AspGlyHisGlyAspAspAspHisGlyHis-36 40-GlnHisGlyLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAla-57 61-ValGlyGlyLysIleThrAspIleAspLeuGluHisAspAspGlyArgProHisTyr-79 82-GluIleValLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArg-100 102-IleSerSerArgArgAspAsp-108 g738 AMPHI Regions - AMPHI 91-LeuMetAsnLeuIleTyrProGlyMetAsnAspIleAla-103 139-IleGlySerLeuLeuGlnSerCysIle-147 201-LysIleProAlaAlaLeu-206 228-ThrTyrIleAlaAlaIleAlaLeuIle-236 271-AlaIleLeuGluThrPheThrGlyIle-279 285-ValGluArgValAlaAsnGlyGlyPheThrAspLeuProArgGlnSer-300 304-LysAlaLeuAlaAlaPheGlnSer-311 316-GlyHisGlyTrpAsnSerPheAla-323 338-AspAsnPheLeuSerThrLeuPheThr-346 353-LeuGlnLeuLeuAlaGlu-358 371-LeuLeuThrGlyIleAlaGlyLeuLeuLysArg-381 398-MetCysHisSerMetLeu-403 461-ArgLeuValAsnSerPheSerPro-468 472-AspSerAlaLysThrLeuAsnArgLys-480 482-AsnGluLeuArgTyrIleSer-488 507-LeuProGluTyrProGluThr-513 549-AlaLysGlnTrpMetArgAlaThr-556 567-TyrAlaAspGluIleArgLysLeuProVal-576 579-ProLeuLeuProGluLeuLeuLysAspCysLysAlaPheAlaAlaAlaPro-595 Antigenic Index - Jameson-Wolf 5-ThrThrValSerGlyAlaArgProAlaAla-14 37-ArgLeuLysProSerProAspPheTyr-45 62-AlaGlyLysLysLeuPheAsp-68 124-TyrGlyGlnGluArgIle-129 167-HisArgGlyGlnGly-171 176-IleGlyGlnArgAsnAsnLeuGly-183 196-LeuAsnGlyGlnArgLysIlePro-203 242-PheArgSerAspLysSerAsnArgArgThrMet-252 283-ThrAlaValGluArgValAlaAsnGlyGlyPheThrAspLeuProArgGlnSerGluTrpAsn-303 316-GlyHisGlyTrpAsnSerPheAla-323 335-ThrIleHisAspAsnPhe-340 378-LeuLeuLysArgSerLeuThrProAlaSer-387 424-ProAlaGluAlaSerAspGlyIleAlaPheLysLysAlaAla-437 467-SerProAlaAlaAspAspSerAlaLysThrLeuAsnArgLysIleAsnGlu-483 508-ProGluTyrProGluThrGlnThrTrpAlaGlu-518 525-LeuLysTyrArgProTyrSerAla-532 542-ArgGlnGlyLysValAlaGluAlaLysGlnTrpMet-553 555-AlaThrGlnSerTyr-559 566-ArgTyrAlaAspGluIleArgLys-573 584-LeuLeuLysAspCysLysAla-590 595-ProGlyHisProGluThrLysProCysLys-604 Hydrophilic Regions - Hopp-Woods 5-ThrThrValSerGlyAlaArgProAlaAla-14 38-LeuLysProSerPro-42 62-AlaGlyLysLysLeuPheAsp-68 125-GlyGlnGluArgIle-129 177-GlyGlnArgAsnAsn-181 198-GlyGlnArgLysIlePro-203 243 -ArgSerAspLysSerAsnArgArgThrMet-252 283-ThrAlaValGluArgValAla-289 295-AspLeuProArgGlnSerGluTrpAsn-303 378-LeuLeuLysArgSerLeuThr-384 425-AlaGluAlaSerAsp-429 431-IleAlaPheLysLysAlaAla-437 468-ProAlaAlaAspAspSerAlaLysThrLeuAsnArgLysIleAsnGlu-483 542-ArgGlnGlyLysValAlaGluAlaLysGlnTrpMet-553 566-ArgTyrAlaAspGluIleArgLys-573 584-LeuLeuLysAspCysLysAla-590 596-GlyHisProGluThrLysProCysLys-604 g739 AMPHI Regions - AMPHI 6-AsnLysProPheArgLeu-ll 53-HisThrAspSerPro-57 88-GlnProAspGlyThrGlu-93 116-AspAlaAlaArgAlaAlaAspSerLeuThrGlyThr-127 131-AlaGluAsnThrLeu-135 Antigenic Index - Jameson-Wolf l-MetAlaLysLysProAsnLysProPheArgLeuThrPro-13 39-PheAsnProAsnGlyAspLysThrLeuGlnThrGluProGlnHisThrAspSerProArgGluThrGluPhe- 62 64-LeuProAsnGlyAlaValGlyGlnAspAlaAlaGlnProGluHisHisHis-80 82-AlaSerSerGluProAlaGlnProAspGlyThrGluGluSerGlySerGlyLeuProSerProAlaAlaProL ysLysAsnArgValLysProArgProSerAspAlaAlaArgAlaAlaAspSerLeuThrGlyThrGlyThrGlnAl aGluAsnThrLeuLysGluThrProVal-140 142-ProThrAsnAlaProHisProGluProArgLysGluThrProGluLysGlnAlaGlnProLysGluThrPro LysGluLysGluThrProLysGluAsnHisThrLysProAspThrProLysAsnThrProAlaLysProHisLysG luIleLeu-193 Hydrophilic Regions - Hopp-Woods 1-MetAlaLysLysProAsnLysProPheArgLeu-ll 41-ProAsnGlyAspLysThrLeuGlnThrGluProGlnHisThrAspSerProArgGluThrGlu-61 69-ValGlyGlnAspAlaAlaGlnProGluHisHisHis-80 82-AlaSerSerGluProAlaGlnProAspGlyThrGluGluSerGlySer-97 103-AlaAlaProLysLysAsnArgValLysProArgProSerAspAlaAlaArgAlaAlaAspSerLeuThr-12 5 129-ThrGlnAlaGluAsnThrLeuLysGluThrPro-139 146-ProHisProGluProArgLysGluThrProGluLysGlnAlaGlnProLysGluThrProLysGluLysGlu ThrProLysGluAsnHisThrLysProAspThrProLysAsnThrProAlaLysProHisLysGluIleLeu-193 g740 AMPHI Regions - AMPHI 6-LeuValArgTrpLeuAlaVal-12 57-IleLysHisHisLeu-61 Antigenic Index - Jameson-Wolf 25-AlaAsnProProGluAspLysProGln-33 57-IleLysHisHisLeu-61 63-GlnGlyPheAspLeuLysArgGlnThr-71 Hydrophilic Regions - Hopp-Woods 27-ProProGluAspLysProGln-33 57-IleLysHisHisLeu-61 63-GlnGlyPheAspLeuLysArgGlnThr-71 g741 AMPHI Regions - AMPHI 35-GlyThrGlyLeuAlaAspAlaLeuThrAla-44 74-GlyAlaGluLysThrPheLysAlaGly-82 138-LysIleAsnAsnProAspLysIleAspSerLeuIle-149 164-ThrAlaPheAsnGlnLeuProAsp-171 205-IleGluHisLeuLys-209 Antigenic Index - Jameson-Wolf 1-Val snArgThrThrPhe-6 12-ThrAlaGlyProAspSerAspArgLeuGlnGlnArgArgGlyGlyGlyGlyGlyVal-30 46-LeuAspHisLysAspLysGlyLeuLys-54 61-SerIleProGlnAsnGly-66 73-GlnGlyAlaGluLysThrPheLysAlaGlyGlyLysAspAsnSerLeuAsnThrGlyLysLeuLysAsnAspL ysIleSerArg-100 107-IleGluValAspGlyGln-112 123-IleTyrLysGlnAspHisSerAla-130 135-ArglleGluLysIleAsnAsnProAspLysIleAspSer-147 149-IleAsnGlnArgSer-153 157-SerAspLeuGlyGlyGluHisThr-164 168-GlnLeuProAspGlyLysAlaGluTyrHisGly-178 180-AlaPheSerSerAspAspAlaAspGlyLysLeu-190 196-PheAlaAlaLysGlnGlyHisGlyLysIleGluHisLeuLysThrProGluGlnAsnVal-215 218-AlaSerAlaGluLeuLysAlaAspGluLysSerHis-229 234-GlyAspThrArgTyrGlyGlyGluGluLysGlyThrTyrArg-247 251-PheGlyAspArgAlaGlnGluIleAlaGly-260 265-LysIleGlyGluLysValHisGlu-272 274-GlyIleAlaAspLysGln-279 Hydrophilic Regions - Hopp-Woods 13-AlaGlyProAspSerAspArgLeuGlnGlnArgArgGlyGlyGly-27 46-LeuAspHisLysAspLysGlyLeuLys-54 73-GlnGlyAlaGluLysThrPheLysAlaGlyGlyLysAspAsnSerLeuAsn-89 91-GlyLysLeuLysAsnAspLysI1eSerArg-100 107-IleGluValAspGly-lll 135-ArgIleGluLysIleAsnAsnProAspLysIleAspSer-147 170-ProAspGlyLysAlaGluTyrHisGly-178 180-AlaPheSerSerAspAspAlaAspGlyLysLeu-190 200-GlnGlyHisGlyLysIleGluHisLeuLysThrProGluGlnAsnVal-215 218-AlaSerAlaGluLeuLysAlaAspGluLysSerHis-229 236-ThrArgTyrGlyGlyGluGluLysGlyThrTyr-246 252-GlyAspArgAlaGlnGluIleAlaGly-260 265-LysIleGlyGluLysValHisGlu-272 274-GlyIleAlaAspLysGln-279 g746 AMPHI Regions - AMPHI 83-ThrAlaAlaAspLysProGlnAsp-90 105-SerGluProGluAsn-109 126-IleLysGlyLeuGluGluSerGluLysLeuGlnGlnAlaGlu-139 154-GluLysValSerAlaThr-159 164-AspThrValAlaValGlu-169 171-ProLysArgThrAlaGluPro-177 181-LysAlaGluArgThr-185 195-ThrLysThrAlaGluLysValAlaAspLysProLys-206 221-SerAlaValLysGluAlaLysLysAlaAspLysAlaGluGly-234 249-GluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLysGluLysSerGlyLysAla-27 1 301-SerThrIleThrGluIleMetThr-308 321-TyrLysAsnAlaArgAspAlaGluArgAspLeu-331 Antigenic Index - Jameson-Wolf l-MetSerGluAsnLysGlnAsnGlu-8 14-GluGlnLeuLysArgArgAsnArgArgArgLeuValThr-26 42-LeuSerSerAspProAlaAspSerAsnProAlaProGlnAlaGlyGluThrGlyAlaThrGluSerGlnThrA 1aAsnThrAlaGln-70 76-SerAlaAlaGluAsnGlyGluThrAlaAlaAspLysProGlnAspLeuAlaGlyGluAspLysProSerAlaA laAspSerGluIleSerGluProGluAsnVal-110 118-AsnAspArgLeuGluAspSerAsnIleLysGlyLeuGluGluSerGluLysLeuGlnGlnAlaGluThrAla LysThrGluProLysGlnAlaLysGlnArgAlaAlaGluLysValSerAlaThrAlaAspSerThrAspThrValA laValGluLysProLysArgThrAlaGluProLysProGlnLysAlaGluArgThrAlaGluAlaLysProLysAl aLysGluThrLysThrAlaGluLysValAlaAspLysProLysThrAlaAlaGluLysThrLysProAspThrAla LysSerAspSerAlaValLysGluAlaLysLysAlaAspLysAlaGluGlyLysLysThrAlaGluLysAspArgS erAspGlyLysLysHisGluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLysGluLysSe rGlyLysAlaGlyLysLysAlaAla-276 280-GlyTyrAlaGluLysGluArgAlaLeuSerLeuGlnArgLysMetLysAlaAlaGlyIle-299 306-IleMetThrAspAsnGlyLysValTyrArgValLysSerSerAsnTyrLysAsnAlaArgAspAlaGluArg AspLeuAsnLysLeuArgVa1-336 Hydrophilic Regions - Hopp-Woods l-MetSerGluAsnLysGlnAsnGlu-8 14-GluGlnLeuLysArgArgAsnArgArgArgLeuVal-25 42-LeuSerSerAspProAlaAspSerAsnPro-51 54-GlnAlaGlyGluThrGlyAlaThrGluSerGlnThr-65 76-SerAlaAlaGluAsnGlyGluThrAlaAlaAspLysProGlnAspLeuAlaGlyGluAspLysProSerAlaA laAspSerGluIleSerGluProGluAsnVal-110 119-AspArgLeuGluAspSerAsnIleLysGlyLeuGluGluSerGluLysLeuGlnGlnAlaGluThrAlaLys ThrGluProLysGlnAlaLysGlnArgAlaAlaGluLysValSerAlaThrAlaAspSerThrAsp-164 166-ValAlaValGluLysProLysArgThrAlaGluProLysProGlnLysAlaGluArgThrAlaGluAlaLys ProLysAlaLysGluThrLysThrAlaGluLysValAlaAspLysProLysThrAlaAlaGluLysThrLysProA spThrAlaLysSerAspSerAlaValLysGluAlaLysLysAlaAspLysAlaGluGlyLysLysThrAlaGluLy sAspArgSerAspGlyLysLysHisGluThrAlaGlnLysThrAspLysAlaAspLysThrLysThrAlaGluLys GluLysSerGlyLysAlaGlyLysLysAlaAla-276 281-TyrAlaGluLysGluArgAlaLeuSerLeuGlnArgLysMetLysAlaAlaGlyIle-299 306-IleMetThrAspAsnGlyLysValTyrArgValLysSerSerAsnTyrLysAsnAlaArgAspAlaGluArg AspLeuAsnLysLeuArgVal-336 g748 AMPHI Regions - AMPHI 22-GlyAlaIleGlyAlaIleGlyGly-29 37-GlyGluThrAlaGluArgThrAlaGluSerGlnHis-48 82-SerAlaLysGlnLeuGluAsnLeuPheArgThrLeu-93 155-LeuGlnGluMetArgAspPheProAsnAspLysLeuGlnLysSerTrp-170 188-GlnThrAlaLeuArgAspIleIleLysHisThr-198 250-GlyValAlaAlaAsnSer-255 257-AspGluProGluTrp-261 268-GlnAlaValArgLeuIleArgArgPheValGluPheTrpAspArg-282 31O-GlnProAspPheAlaLysAspProGlu-318 330-LeuAlaAsnProArgAspProGlu-337 390-LeuGluGluTyrIleSerProPhe-397 Antigenic Index - Jameson-Wolf l-MetSerGlnAsnGlnProAlaGlnProThrLysArgAsnLeuPhe-15 30-TyrPheGlyGlyLysLysGlnGlyGluThrAlaGluArgThrAlaGluSerGlnHisSerProGlnAla-52 80-AlaGlnSerAlaLysGlnLeuGluAsn-88 lOl-ThrGlnGlyGlyGluTyrGlnAspGlyAspAspLysLeuProSerAlaGlySerGly-119 125-PheAsnProAspGlyLeuThr-131 139-SerLeuPheAspGlyArgPheGlyLeuLysAspLysLysThrValHis-154 156-GlnGluMetArgAspPheProAsnAspLysLeuGlnLysSerTrpCysAspGlyAspLeuSer-176 183-ThrProGluThrCys-187 208-IleAspGlyTrpGlnProLysSerGluProGlyAlaMetAla-221 226-LeuGlyPheArgAspGlyThrGlyAsnProLysValSerAspProLysThrAlaAspGlu-245 255-SerLeuAspGluProGluTrpAlaLysAsnGlySerTyrGlnAla-269 271-ArgLeuIleArgArgPhe-276 279-PheTrpAspArgThrProLeuGlnGluGlnThrAspIlePheGlyArgArgLysTyrSerGlyAlaProMet AspGlyLysLysGluAlaAspGlnProAspPheAlaLysAspProGluGlyAspIleThrProLysAspSerHisM etArgLeuAlaAsnProArgAspProGluPheLeuLys-340 348-AlaTyrSerTyrSerArgGlyProAlaSerSerGlyGlnLeu-361 385-LeuAsnGlyGluProLeuGluGluTyr-393 407-GlyValGlyLysGlyGlyPhe-413 Hydrophilic Regions - Hopp-Woods 8-GlnProThrLysArgAsnLeuPhe-15 32-GlyGlyLysLysGlnGlyGluThrAlaGluArgThrAlaGluSerGlnHis-48 80-AlaGlnSerAlaLysGlnLeuGluAsn-88 104-GlyGluTyrGlnAspGlyAspAspLysLeuProSer-115 145-PheGlyLeuLysAspLysLysThrValHis-154 156-GlnGluMetArgAspPheProAsnAspLysLeuGlnLysSerTrpCysAspGlyAspLeu-175 211-TrpGlnProLysSerGluProGlyAlaMetAla-221 229-ArgAspGlyThrGlyAsnProLysValSerAspProLysThrAlaAsp-244 255-SerLeuAspGluProGluTrpAlaLys-263 271-ArgLeuIleArgArgPhe-276 283-ThrProLeuGlnGluGlnThrAspIlePheGlyArgArgLysTyrSer-298 301-ProMetAspGlyLysLysGluAlaAspGlnProAspPheAlaLysAspProGluGlyAspIleThrProLys AspSerHisMet-328 331-AlaAsnProArgAspProGluPheLeuLys-340 353-ArgGlyProAlaSer-357 388-GluProLeuGluGluTyr-393 g749 AMPHI Regions - AMPHI 1-MetArgLysPheAsnLeuThrAlaLeuSerValMetLeuAlaLeuGlyLeuThrAlaCysGlnProProGluAl aGluLysAlaAlaProAlaAlaSerGlyGluThrGlnSerAlaAsnGluGlyGlySerValGlylleAlaValAsn AspAsnAlaCysGluProMetAsnLeuThrValProSerGlyGlnValValPheAsnlleLysAsnAsnSerGlyA rgLysLeuGluTrpGluIleLeuLysGlyValMetValValAspGluArgGluAsnlleAlaProGlyLeuSerAs pLysMetThrValThrLeuLeuProGlyGluTyrGluMetThrCysGlyLeuLeuThrAsnProArgGlyLysLeu ValValAlaAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuProGlnProLeuAlaAspT yrLysAlaTyrValGlnGlyGluValLysGluLeuAlaAlaLysThrLysThrPheThrGluAlaValLysAlaGl yAspIleGluLysAlaLysSerLeuPheAlaAlaThrArgValHisTyrGluArglleGluProIleAlaGluLeu PheSerGluLeuAspProVallleAspAlaCysGluAspAspPheLysAspGlyAlaLysAspAlaGlyPheThrG lyPheHisArglleGluHisAlaLeuTrpValGluLysAspValSerGlyValLysGluThrAlaAlaLysLeuMe tThrAspValGluAlaLeuGlnLysGluIleAspAlaLeuAlaPheProProGlyLysValValGlyGlyAlaSer GluLeuIleGluGluAlaAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSerAspP heGlnAlaAsnAlaAspGlySerLysLysIleValAspLeuPheArgProLeuIleGluAlaLysAsnLysAlaLe uLeuGluLysThrAspThrAsnPheLysGlnValAsnGluIleLeuAlaLysTyrArgThrLysAspGlyPheGlu ThrTyrAspLysLeuSerGluAlaAspArgLysAlaLeuGlnAlaProIleAsnAlaLeuAlaGluAspLeuAlaG InLeuArgGlyl1eLeuGlyLeuLys-388 Antigenic Index - Jameson-Wolf 1-MetArgLysPheAsnLeuThrAlaLeuSerValMetLeuAlaLeuGlyLeuThrAlaCysGlnProProGluAl aGluLysAlaAlaProAlaAlaSerGlyGluThrGlnSerAlaAsnGluGlyGlySerValGlylleAlaValAsn AspAsnAlaCysGluProMetAsnLeuThrValProSerGlyGlnValValPheAsnlleLysAsnAsnSerGlyA rgLysLeuGluTrpGluIleLeuLysGlyValMetValValAspGluArgGluAsnlleAlaProGlyLeuSerAs pLysMetThrValThrLeuLeuProGlyGluTyrGluMetThrCysGlyLeuLeuThrAsnProArgGlyLysLeu ValValAlaAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuProGlnProLeuAlaAspT yrLysAlaTyrValGlnGlyGluValLysGluLeuAlaAlaLysThrLysThrPheThrGluAlaValLysAlaGl yAspIleGluLysAlaLysSerLeuPheAlaAlaThrArgValHisTyrGluArglleGluProIleAlaGluLeu PheSerGluLeuAspProVallleAspAlaCysGluAspAspPheLysAspGlyAlaLysAspAlaGlyPheThrG lyPheHisArglleGluHisAlaLeuTrpValGluLysAspValSerGlyValLysGluThrAlaAlaLysLeuMe tThrAspValGluAlaLeuGlnLysGluIleAspAlaLeuAlaPheProProGlyLysValValGlyGlyAlaSer GluLeuIleGluGluAlaAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSerAspP heGlnAlaAsnAlaAspGlySerLysLysIleValAspLeuPheArgProLeuIleGluAlaLysAsnLysAlaLe uLeuGluLysThrAspThrAsnPheLysGlnValAsnGluIleLeuAlaLysTyrArgThrLysAspGlyPheGlu ThrTyrAspLysLeuSerGluAlaAspArgLysAlaLeuGlnAlaProIleAsnAlaLeuAlaGluAspLeuAlaG InLeuArgGlylleLeuGlyLeuLys-388 Hydrophilic Regions - Hopp-Woods 1-MetArgLysPheAsnLeuThrAlaLeuSerValMetLeuAlaLeuGlyLeuThrAlaCysGlnProProGluAl aGluLysAlaAlaProAlaAlaSerGlyGluThrGlnSerAlaAsnGluGlyGlySerValGlylleAlaValAsn AspAsnAlaCysGluProMetAsnLeuThrValProSerGlyGlnValValPheAsnlleLysAsnAsnSerGlyA rgLysLeuGluTrpGluIleLeuLysGlyValMetValValAspGluArgGluAsnlleAlaProGlyLeuSerAs pLysMetThrValThrLeuLeuProGlyGluTyrGluMetThrCysGlyLeuLeuThrAsnProArgGlyLysLeu ValValAlaAspSerGlyPheLysAspThrAlaAsnGluAlaAspLeuGluLysLeuProGlnProLeuAlaAspT yrLysAlaTyrValGlnGlyGluValLysGluLeuAlaAlaLysThrLysThrPheThrGluAlaValLysAlaGl yAspIleGluLysAlaLysSerLeuPheAlaAlaThrArgValHisTyrGluArglleGluProIleAlaGluLeu PheSerGluLeuAspProVallleAspAlaCysGluAspAspPheLysAspGlyAlaLysAspAlaGlyPheThrG lyPheHisArglleGluHisAlaLeuTrpValGluLysAspValSerGlyValLysGluThrAlaAlaLysLeuMe tThrAspValGluAlaLeuGlnLysGluIleAspAlaLeuAlaPheProProGlyLysValValGlyGlyAlaSer GluLeuIleGluGluAlaAlaGlySerLysIleSerGlyGluGluAspArgTyrSerHisThrAspLeuSerAspP heGlnAlaAsnAlaAspGlySerLysLysIleValAspLeuPheArgProLeuIleGluAlaLysAsnLysAlaLe uLeuGluLysThrAspThrAsnPheLysGlnValAsnGluIleLeuAlaLysTyrArgThrLysAspGlyPheGlu ThrTyrAspLysLeuSerGluAlaAspArgLysAlaLeuGlnAlaProIleAsnAlaLeuAlaGluAspLeuAlaG lnLeuArgGlyIleLeuGlyLeuLys-388 g750 AMPHI Regions - AMPHI 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuProAlaAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerGlnAlaAlaSerThrProValAlaThrLeuThrValProThrAlaArgGlyAspAla ValValProLysAsnProGluArgValAlaValTyrAspTrpAlaAlaLeuAspThrLeuThrGluProGlyValA snValGlyAlaThrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLysAlaAlaThrValGlyTh rLeuPheGluProAspCysGluSerLeuHisArgHisAsnProGlnPheVallleThrGlyGlyProGlyAlaGlu AlaTyrGluGlnLeuAlaLysAsnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyG luLysGlnMetGluThrLeuSerArgllePheGlyLysGluAlaArgValAlaGluLeuAsnAlaGlnlleAspAl aLeuPheAlaGlnLysArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysVal SerAlaPheGlyThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerL euArgAsnGluGlyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProGlyTrpIlePhellell eAspArgThrAlaAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValCysGlyThr AsnAlaTrpLysArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlyAlaArgGlnLeuI leGlnAlaAlaGluGlnLeuLysAlaAlaPheGluLysAlaGluProValAlaAlaGln-323 Antigenic Index - Jameson-Wolf 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuProAlaAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerGlnAlaAlaSerThrProValAlaThrLeuThrValProThrAlaArgGlyAspAla ValValProLysAsnProGluArgValAlaValTyrAspTrpAlaAlaLeuAspThrLeuThrGluProGlyValA snValGlyAlaThrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLysAlaAlaThrValGlyTh rLeuPheGluProAspCysGluSerLeuHisArgHisAsnProGlnPheVallleThrGlyGlyProGlyAlaGlu AlaTyrGluGlnLeuAlaLysAsnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyG luLysGlnMetGluThrLeuSerArgllePheGlyLysGluAlaArgValAlaGluLeuAsnAlaGlnlleAspAl aLeuPheAlaGlnLysArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysVal SerAlaPheGlyThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerL euArgAsnGluGlyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProGlyTrpIlePhellell eAspArgThrAlaAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValCysGlyThr AsnAlaTrpLysArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlyAlaArgGlnLeuI leGlnAlaAlaGluGlnLeuLysAlaAlaPheGluLysAlaGluProValAlaAlaGln-323 Hydrophilic Regions - Hopp-Woods 1-ValLysProArgPheTyrTrpAlaAlaCysAlaValLeuProAlaAlaCysSerProGluProAlaAlaGluLy sThrValSerAlaAlaSerGlnAlaAlaSerThrProValAlaThrLeuThrValProThrAlaArgGlyAspAla ValValProLysAsnProGluArgValAlaValTyrAspTrpAlaAlaLeuAspThrLeuThrGluProGlyValA ΞnValGlyAlaThrThrAlaProValArgValAspTyrLeuGlnProAlaPheAspLysAlaAlaThrValGlyTh rLeuPheGluProAspCysGluSerLeuHisArgHisAsnProGlnPheVallleThrGlyGlyProGlyAlaGlu AlaTyrGluGlnLeuAlaLysAsnAlaThrThrlleAspLeuThrValAspAsnGlyAsnlleArgThrSerGlyG luLysGlnMetGluThrLeuSerArgllePheGlyLysGluAlaArgValAlaGluLeuAsnAlaGlnlleAspAl aLeuPheAlaGlnLysArgGluAlaAlaLysGlyLysGlyArgGlyLeuValLeuSerValThrGlyAsnLysVal SerAlaPheGlyThrGlnSerArgLeuAlaSerTrpIleHisGlyAspIleGlyLeuProProValAspGluSerL euArgAsnGluGlyHisGlyGlnProValSerPheGluTyrlleLysGluLysAsnProGlyTrpIlePhellell eAspArgThrAlaAlalleGlyGlnGluGlyProAlaAlaValGluValLeuAspAsnAlaLeuValCysGlyThr AsnAlaTrpLysArgLysGlnllelleValMetProAlaAlaAsnTyrlleValAlaGlyGlyAlaArgGlnLeuI leGlnAlaAlaGluGlnLeuLysAlaAlaPheGluLysAlaGluProValAlaAlaGln-323 g760 AMPHI Regions - AMPHI 1-AsnAsnArgAsnThrArgTyrAlaAlaLeuGlyLysArgValMetGluGlyValGluThrGluIleSerGlyAl alleThrProLysTrpGlnlleHisAlaGlyTyrSerTyrLeuHisSerGlnlleLysThrAlaAlaAsnProArg AspAspGlyllePheLeuLeuValProLysHisSerAlaAsnLeuTrpThrThrTyrGlnValThrProGlyLeuT hrValGlyGlyGlyValAsnAlaMetSerGlylleThrSerSerAlaGlyMetHisAlaGlyGlyTyrAlaThrPh eAspAlaMetAlaAlaTyrArgPheThrProLysLeuLysLeuGlnlleAsnAlaAspAsnllePheAsnArgHis TyrTyrAlaArgValGlyGlyThrAsnThrPheAsnlleProGlySerGluArgSerLeuThrAlaAsnLeuArgT yrSerPhe-154 Antigenic Index - Jameson-Wolf 1-AsnAsnArgAsnThrArgTyrAlaAlaLeuGlyLysArgValMetGluGlyValGluThrGluIleSerGlyAl alleThrProLysTrpGlnlleHisAlaGlyTyrSerTyrLeuHisSerGlnlleLysThrAlaAlaAsnProArg AspAspGlyllePheLeuLeuValProLysHisSerAlaAsnLeuTrpThrThrTyrGlnValThrProGlyLeuT hrValGlyGlyGlyValAsnAlaMetSerGlylleThrSerSerAlaGlyMetHisAlaGlyGlyTyrAlaThrPh eAspAlaMetAlaAlaTyrArgPheThrProLysLeuLysLeuGlnlleAsnAlaAspAsnllePheAsnArgHis TyrTyrAlaArgValGlyGlyThrAsnThrPheAsnlleProGlySerGluArgSerLeuThrAlaAsnLeuArgT yrSerPhe-154 Hydrophilic Regions - Hopp-Woods 1-AsnAsnArgAsnThrArgTyrAlaAlaLeuGlyLysArgValMetGluGlyValGluThrGluIleSerGlyAl alleThrProLysTrpGlnlleHisAlaGlyTyrSerTyrLeuHisSerGlnlleLysThrAlaAlaAsnProArg AspAspGlyllePheLeuLeuValProLysHisSerAlaAsnLeuTrpThrThrTyrGlnValThrProGlyLeuT hrValGlyGlyGlyValAsnAlaMetSerGlylleThrSerSerAlaGlyMetHisAlaGlyGlyTyrAlaThrPh eAspAlaMetAlaAlaTyrArgPheThrProLysLeuLysLeuGlnlleAsnAlaAspAsnllePheAsnArgHis TyrTyrAlaArgValGlyGlyThrAsnThrPheAsnlleProGlySerGluArgSerLeuThrAlaAsnLeuArgT yrSerPhe-154 g767 AMPHI Regions - AMPHI 41-GlyLysIleGluValLeuGluPhePheGlyTyrPheCysVal-54 89-GlyLeuAlaArgMetAlaAlaAlaValLys-98 140-LysLysLeuMetArgAlaTyrAspSerProGlu-150 160-LysLeuThrGluGlnTyr-165 187-PheAspGlyGlyValHisThrIleLysGluLeuValAla-199 Antigenic Index - Jameson-Wolf 23 -ThrGluGlyGluAspTyrLeuVal-30 32-AspLysProIleProGlnGluGlnProGlyLysIleGluVal-45 66-LeuGlyLysAlaLeuProSerAspThrTyrLeuArg-77 99-LeuSerGlyLeuLysTyrGlnAla-106 115-TyrGluGlnLysIleArgLeuGluAsnArgAlaValAla-127 132-LeuSerGlnLysGlyPheAspGlyLysLysLeuMetArgAlaTyrAspSerProGluAla-151 157-LysMetGlnLysLeuThrGluGlnTyrGlyIleAspSerThrPro-171 175-ValGlyGlyLysTyrArgVal-181 183 -PheAsnAsnGlyPheAspGlyGly-190 197-LeuValAlaLysValArgGluGluArgLysArgGlnThrProAlaValGlnLys-214 Hydrophilic Regions - Hopp-Woods 23-ThrGluGlyGluAsp-27 33-LysProIleProGlnGluGlnProGlyLysIleGluVal-45 115-TyrGluGlnLysIleArgLeuGluAsnArgAlaValAla-127 135-LysGlyPheAspGlyLysLysLeuMetArgAlaTyrAspSerProGluAla-151 157-LysMetGlnLysLeuThrGlu-163 197-LeuValAlaLysValArgGluGluArgLysArgGlnThrProAlaValGlnLys-214 g768 AMPHI Regions - AMPHI 1-MetAsnIleLysGlnLeuIleThrAlaAlaLeuIleAlaSerAlaAlaPheAlaThrGlnAlaAlaProGlnLy sProValSerAlaAlaGlnThrAlaGlnHisSerAlaValTrpIleAspValArgSerGluGlnGluPheSerGlu GlyHisLeuHisAsnAlaValAsnlleProValAspGlnlleValArgArglleTyrGluAlaAlaProAspLysA spThrProValAsnLeuTyrCysArgSerGlyArgArgAlaGluAlaAlaLeuGlnGluLeuLysLysAlaGlyTy rThrAsnValAlaAsnHisGlyGlyTyrGluAspLeuLeuLysLysGlyMetLys-119 Antigenic Index - Jameson-Wolf 1-MetAsnIleLysGlnLeuIleThrAlaAlaLeuIleAlaSerAlaAlaPheAlaThrGlnAlaAlaProGlnLy sProValSerAlaAlaGlnThrAlaGlnHisSerAlaValTrpIleAspValArgSerGluGlnGluPheSerGlu GlyHisLeuHisAsnAlaValAsnlleProValAspGlnlleValArgArglleTyrGluAlaAlaProAspLysA spThrProValAsnLeuTyrCysArgSerGlyArgArgAlaGluAlaAlaLeuGlnGluLeuLysLysAlaGlyTy rThrAsnValAlaAsnHisGlyGlyTyrGluAspLeuLeuLysLysGlyMetLys-119 Hydrophilic Regions - Hopp-Woods 1-MetAsnIleLysGlnLeuIleThrAlaAlaLeuIleAlaSerAlaAlaPheAlaThrGlnAlaAlaProGlnLy sProValSerAlaAlaGlnThrAlaGlnHisSerAlaValTrpIleAspValArgSerGluGlnGluPheSerGlu GlyHisLeuHisAsnAlaValAsnlleProValAspGlnlleValArgArglleTyrGluAlaAlaProAspLysA spThrProValAsnLeuTyrCysArgSerGlyArgArgAlaGluAlaAlaLeuGlnGluLeuLysLysAlaGlyTy rThrAsnValAlaAsnHisGlyGlyTyrGluAspLeuLeuLysLysGlyMetLys-119 g769 AMPHI Regions - AMPHI 1-LeuIleMetValIlePheTyrPheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLe uProLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProCysGluProAspLeuArgSerArgProGluPheArg LeuHisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuG InValAspGlyGluThrLeuLeuLysAsnProGluLeuLeuΞerArgAlaMetTyrSerAlaValValSerAsnAs nlleAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaArgGlnAspLysMetLeuAlaLeuTyrAla GlnGlylleLeuAlaGlnAlaGluGlyArgValLysGluAlaValSerHisTyrArgGluLeuIleAlaAlaGlnP roAspAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAspArgGlnAsnGluAlaAlaAlaAspGl nPheAspArgLeuLysThrGluAspLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArg GluArgAspAlaTrpLysValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysGlnG InGlnTyrGlyAsnTrpThrPheProLysGlnValAspGlyThrAlaValAsnTyrArgPheGlyAlaGluLysLy sTrpSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLys PheAsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspValGlyLeuAlaValP heHisGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrAlaAsnGlyAlaArgLeuTyrPheAsnArgTrpGl nThrProArgTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAsnThrArgArgAlaArgSerAspAsn ThrHisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpThrGlyGlyLeuAspPheT yrArgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTr pGlyGlySerGlyLeuSerSerLeuPheArgLeuGlyValAlaLysArgHisTyrGluLysProGlyPhePheSer SerPheLysGlyGluArgArgArgAspLysGluSerAspThrSerLeuSerLeuTrpHisArgAlaLeuHisPheL ysGlylleThrProArgLeuThrLeuSerHisArgGluThrTrpSerAsnAspValPheAsnGluTyrGluLysAs nArgAlaPheValGluPheAsnLysThrPhe-491 Antigenic Index - Jameson-Wolf 1-LeuIleMetValIlePheTyrPheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLe uProLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProCysGluProAspLeuArgSerArgProGluPheArg LeuHisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuG InValAspGlyGluThrLeuLeuLysAsnProGluLeuLeuSerArgAlaMetTyrSerAlaValValSerAsnAs nlleAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaArgGlnAspLysMetLeuAlaLeuTyrAla GlnGlylleLeuAlaGlnAlaGluGlyArgValLysGluAlaValSerHisTyrArgGluLeuIleAlaAlaGlnP roAspAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAspArgGlnAsnGluAlaAlaAlaAspGl nPheAspArgLeuLysThrGluAspLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArg GluArgAspAlaTrpLysValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysGlnG InGlnTyrGlyAsnTrpThrPheProLysGlnValAspGlyThrAlaValAsnTyrArgPheGlyAlaGluLysLy ΞTrpSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLys PheAsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspValGlyLeuAlaValP heHisGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrAlaAsnGlyAlaArgLeuTyrPheAsnArgTrpGl nThrProArgTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAsnThrArgArgAlaArgSerAspAsn ThrHisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpThrGlyGlyLeuAspPheT yrArgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTr pGlyGlySerGlyLeuSerSerLeuPheArgLeuGlyValAlaLysArgHisTyrGluLysProGlyPhePheSer SerPheLysGlyGluArgArgArgAspLysGluSerAspThrSerLeuSerLeuTrpHisArgAlaLeuHisPheL ysGlylleThrProArgLeuThrLeuSerHisArgGluThrTrpSerAsnAspValPheAsnGluTyrGluLysAs nArgAlaPheValGluPheAsnLysThrPhe-491 Hydrophilic Regions - Hopp-Woods 1-LeuIleMetValIlePheTyrPheTyrPheCysGlyLysThrPheMetProAlaArgAsnArgTrpMetLeuLe uProLeuLeuAlaSerAlaAlaTyrAlaGluGluThrProCysGluProAspLeuArgSerArgProGluPheArg LeuHisGluAlaGluValLysProIleAspArgGluLysValProGlyGlnValArgGluLysGlyLysValLeuG InValAspGlyGluThrLeuLeuLysAsnProGluLeuLeuSerArgAlaMetTyrSerAlaValValSerAsnAs nlleAlaGlylleArgVallleLeuProIleTyrLeuGlnGlnAlaArgGlnAspLysMetLeuAlaLeuTyrAla GlnGlylleLeuAlaGlnAlaGluGlyArgValLysGluAlaValSerHisTyrArgGluLeuIleAlaAlaGlnP roAspAlaProAlaValArgMetArgLeuAlaAlaAlaLeuPheGluAspArgGlnAsnGluAlaAlaAlaAspGl nPheAspArgLeuLysThrGluAspLeuProProGlnLeuMetGluGlnValGluLeuTyrArgLysAlaLeuArg GluArgAspAlaTrpLysValAsnGlyGlyPheSerValThrArgGluHisAsnlleAsnGlnAlaProLysGlnG InGlnTyrGlyAsnTrpThrPheProLyΞGlnValAspGlyThrAlaValAsnTyrArgPheGlyAlaGluLysLy ΞTrpSerLeuLysAsnGlyTrpTyrThrThrAlaGlyGlyAspValSerGlyArgValTyrProGlyAsnLysLys PheAsnAspMetThrAlaGlyValSerGlyGlylleGlyPheAlaAspArgArgLysAspValGlyLeuAlaValP heHisGluArgArgThrTyrGlyAsnAspAlaTyrSerTyrAlaAsnGlyAlaArgLeuTyrPheAsnArgTrpGl nThrProArgTrpGlnThrLeuSerSerAlaGluTrpGlyArgLeuLysAsnThrArgArgAlaArgSerAspAsn ThrHisLeuGlnlleSerAsnSerLeuValPheTyrArgAsnAlaArgGlnTyrTrpThrGlyGlyLeuAspPheT yrArgGluArgAsnProAlaAspArgGlyAspAsnPheAsnArgTyrGlyLeuArgPheAlaTrpGlyGlnGluTr pGlyGlySerGlyLeuSerSerLeuPheArgLeuGlyValAlaLysArgHisTyrGluLysProGlyPhePheSer SerPheLysGlyGluArgArgArgAspLysGluSerAspThrSerLeuSerLeuTrpHisArgAlaLeuHisPheL ysGlylleThrProArgLeuThrLeuSerHisArgGluThrTrpSerAsnAspValPheAsnGluTyrGluLysAs nArgAlaPheValGluPheAsnLysThrPhe-491 g770 AMPHI Regions - AMPHI 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuProThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnMetLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaSerValSerCysValGlnThrAlaSerSerlleSerPheAspGluThrAlaValArgLysProLysGl uValPheLysArgGlyThrGlyPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysAla PheAlaTyrLeuValTyrSerAspLysIleValGlnGlySerProLysAsnSerLeuSerAlaValSerCysPheG lySerGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyLysLeuLeuAlaGlyAlaCysIlelleSe rAsnProIleLysAsnProAspLysArg-186 Antigenic Index - Jameson-Wolf 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuProThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnMetLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaSerValSerCysValGlnThrAlaSerSerlleSerPheAspGluThrAlaValArgLysProLysGl uValPheLysArgGlyThrGlyPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysAla PheAlaTyrLeuValTyrSerAspLysIleValGlnGlySerProLysAsnSerLeuSerAlaValSerCysPheG lySerGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyLysLeuLeuAlaGlyAlaCysIlelleSe rAsnProl1eLysAsnProAspLysArg-186 Hydrophilic Regions - Hopp-Woods 1-MetAsnArgLeuLeuLeuLeuSerAlaAlaValLeuProThrAlaCysGlySerGlyGluThrAspLysIleGl yArgAlaSerThrValPheAsnMetLeuGlyLysAsnAspArglleGluValGluGlyPheAspAspProAspVal GlnGlyValAlaCysTyrlleSerTyrAlaLysLysGlyGlyLeuLysGluMetValAsnLeuGluGluAspAlaS erAspAlaSerValSerCysValGlnThrAlaSerSerlleSerPheAspGluThrAlaValArgLysProLysGl uValPheLysArgGlyThrGlyPheAlaPheLysSerArgGlnlleValArgTyrTyrAspProLysArgLysAla PheAlaTyrLeuValTyrSerAspLysIleValGlnGlyΞerProLysAsnSerLeuSerAlaValSerCysPheG lySerGlylleProGlnThrAspGlyValGlnAlaAspThrSerGlyLysLeuLeuAlaGlyAlaCysIlelleSe rAsnProI1eLysAsnProAspLysArg-186 g771 AMPHI Regions - AMPHI 49-SerIleAlaHisThr-53 133-IleGlnAspLeuPheAspGlyAla-140 312-GlyIleAlaAsnIleGlyAsn-318 358-LeuGlnAspThrValAspArgLeuPro-366 369-ArgPheIleSerArgLeuAspGlySer-377 391-AsnGlyThrPheAsp-395 427-TyrLeuAspGluPheArg-432 437-LysIlePheProAspIleLeuGlyArgLeuSerGly-448 523-LeuGlnAspLeuPheGlyPheHis-530 581-GlyLeuSerGlyLys-585 601-IleSerAspGlyIleSerArgHisIleAspThr-611 Antigenic Index - Jameson-Wolf 37-PheThrProGluAsnlleArgSer rgLeuGlnGln-48 52-HisThrHisArgLysIleSerPhe-59 61-AlaAspIleArgArgArgLeuLeuProArgProThrVal-73 79-ThrIleThrGluProAspGlyGlyArg-87 90-ValSerValLysGluThrLysIle-97 104-LeuTrpSerAspArgIleGlnVal-lll 122-AlaLeuThrArgAspArgAsnGlyAlaTrp-131 135-AspLeuPheAspGlyAlaLysHisSerAlaSerValAsn-147 150-IleValGluAsnSerThrValArg-157 174-LeuGlnSerProAspSerSerGlyGlnGlnPheGluSerSerGly-188 197-ValProTrpLysSerArgGlyLeuPhe-205 208-AspGlyIleGlyThrProGluIleSerPro-217 222-AlaSerThrSerLeuAspGlyHisGly-230 235-ThrThrGlySerProSerValArgPheAsnAlaGlyGlyAlaAsp-249 255-LeuArgAlaAspThrSerPhe-261 275-LeuLysAsnAsnSerIleLysThrGlyThrVal-285 291-AlaGlyGlyGluTyrAlaArgTrpAspGlySerPheLysLeuAspLysAlaAsnLeu-309 317-GlyAsnAlaGluIleSerGlySerPheLysThrProArgLeuGln-331 342-TrpSerArgAspAsnGlyLeuAspAlaProArg-352 360-AspThrValAspArgLeuProGlnProArgPheIleSerArgLeuAspGlySerLeu-378 389-GluLeuAsnGlyThrPheAspArgGlnProVal-399 404-LysTyrThrArgGluGlyAlaProHisLeu-413 429-AspGluPheArgGlnGlnAsnGlyLysIle-438 443-LeuGlyArgLeuSerGlyAsnValGluAla-452 464-LeuGlnLeuAspAspMetGlu-470 473-LeuHisAlaAspLysAspHisIleAla-481 483-SerArgPheLysSerGlyLeuTyrGlyGlyHisThrGluGlyGlyIle-498 502-AsnThrArgProAlaThrTyrArgLeuGlnGlnAsnAlaSerAsn-516 531-SerPheSerGlyAsnGlyAspAlaVal-539 543-ThrAlaSerGlyGluAsnArgLysGlnLeuIleArgSerLeuGlnGlySerLeu-560 564-IleSerAsnGlyAla-568 573-AspMetAspSerIleLeuLysAsnGlyLeuSerGlyLysIleSerGly-588 597-LeuAsnSerGluIleSerAspGlyIleSerArgHisIleAsp-610 623-AsnGlyTyrThrAsnLeuAspThrGlnGluLeuSerGlu-635 642-AlaValHisProLysAsnLysProIlePro-651 656-GlyThrValAspLysProSerIleThrValAspTyrGlyArgLeuThrGlyGlyIleAsnSerArgLysGlu LysGlnLysIleLeuGlu-685 695-LeuLysProLysGluPro-700 Hydrophilic Regions - Hopp-Woods 40-GluAsnIleArgSerArgLeuGln-47 53-ThrHisArgLysIleSerPhe-59 61-AlaAspIleArgArgArgLeuLeuPro-69 81-ThrGluProAspGlyGlyArg-87 90-ValSerValLysGluThrLysIle-97 122-AlaLeuThrArgAspArgAsnGly-129 135-AspLeuPheAspGlyAlaLysHisSerAlaSer-145 175-GlnSerProAspSerSerGlyGlnGlnPheGlu-185 255-LeuArgAlaAspThrSerPhe-261 302-PheLysLeuAspLysAlaAsnLeu-309 325-PheLysThrProArgLeu-330 344-ArgAspAsnGlyLeuAspAlaProArg-352 360-AspThrValAspArgLeuProGln-367 370-PheIleSerArgLeuAspGly-376 392-GlyThrPheAspArgGlnProVal-399 404-LysTyrThrArgGluGlyAlaPro-411 429-AspGluPheArgGlnGlnAsn-435 465-GlnLeuAspAspMetGlu-470 473-LeuHisAlaAspLysAspHisIleAla-481 544-AlaSerGlyGluAsnArgLysGlnLeuIle-553 600-GluIleSerAspGlyIleSerArgHisIleAsp-610 629-AspThrGlnGluLeuSerGlu-635 643-ValHisProLysAsnLysProIlePro-651 656-GlyThrValAspLysProSerIle-663 674-1leAsnSerArgLysGluLysGlnLys11eLeuGlu-685 696-LysProLysGluPro-700 g772 AMPHI Regions - AMPHI 1-ValPheGlyThrValLeuArgThrAspAlaAspCysLeuGlnIleIleValValGlyLysPhePheGlnValVa lAlaTyrGlyPheAlaAlaLeuAlaGluGlyGluPheHisGlnPheGlyGluMetlleGluIleValArgLeuAla AspThrValPheHisArgAsnHisAlaHisHisCysGlylleAspPheArgArgGlylleGluArgPheGlyArgH isValAsnGlnGlnLeuHisIleGluLysIleLeuGlnHisHisThrGlnAlaThrValValValAlaPheArgAr gGlyAsnHisAlaLeuAspHisPhePheLeuGlnHisLysValHisIleGlyAspIleValArgHisLeuArgGln PheGluGlnLysArgArgGlyAspVallleArgGlnValAlaAspAspPheLeuPheAlaAspAlaValGluIleL ysLeuGlnHisValAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspValAl aValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnCysArgGlnThrArgAlaAsp PheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnLysI leLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerSerSerValGluThrProProPheArgAl aAlaGlySerAspSerValTrpAlaGlyArgAsnProPheGlnlleArgThrThrHisArgAlaValLeuTyrVal SerSerCysValLeuGluHisLysCysValTyrSerIleArgLeuMetSerAlaLeu-297 Antigenic Index - Jameson-Wolf 1-ValPheGlyThrValLeuArgThrAspAlaAspCysLeuGlnIleIleValValGlyLysPhePheGlnValVa lAlaTyrGlyPheAlaAlaLeuAlaGluGlyGluPheHisGlnPheGlyGluMetlleGluIleValArgLeuAla AspThrValPheHisArgAsnHisAlaHisHisCysGlylleAspPheArgArgGlylleGluArgPheGlyArgH isValAsnGlnGlnLeuHisIleGluLysIleLeuGlnHisHisThrGlnAlaThrValValValAlaPheArgAr gGlyAsnHisAlaLeuAspHisPhePheLeuGlnHisLysValHisIleGlyAspIleValArgHisLeuArgGln PheGluGlnLysArgArgGlyAspVallleArgGlnValAlaAspAspPheLeuPheAlaAspAlaValGluIleL ysLeuGlnHisValAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspValAl aValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnCysArgGlnThrArgAlaAsp PheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnLysI leLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerSerSerValGluThrProProPheArgAl aAlaGlySerAspSerValTrpAlaGlyArgAsnProPheGlnlleArgThrThrHisArgAlaValLeuTyrVal SerSerCysValLeuGluHisLysCysValTyrSerIleArgLeuMetSerAlaLeu-297 Hydrophilic Regions - Hopp-Woods 1-ValPheGlyThrValLeuArgThrAspAlaAspCysLeuGlnIleIleValValGlyLysPhePheGlnValVa lAlaTyrGlyPheAlaAlaLeuAlaGluGlyGluPheHisGlnPheGlyGluMetlleGluIleValArgLeuAla AspThrValPheHisArgAsnHisAlaHisHisCysGlylleAspPheArgArgGlylleGluArgPheGlyArgH isValAsnGlnGlnLeuHisIleGluLysIleLeuGlnHisHisThrGlnAlaThrValValValAlaPheArgAr gGlyAsnHisAlaLeuAspHisPhePheLeuGlnHisLysValHisIleGlyAspIleValArgHisLeuArgGln PheGluGlnLysArgArgGlyAspVallleArgGlnValAlaAspAspPheLeuPheAlaAspAlaValGluIleL ysLeuGlnHisValAlaPheValAsnHisGlnPhelleArgLysArgGlnArgPheGlnThrAlaTyrAspValAl aValAspPheAspAsnValGlnAlaValGlnLeuPheArgGlnArgPheGlyAsnCysArgGlnThrArgAlaAsp PheAsnHisAspIlelleArgLeuArgAlaHisGlyValAspAsnlleAlaAspAsnProArgValLeuGlnLysI leLeuProGluThrLeuAlaGlyPheValPhePheHisArgValSerSerSerValGluThrProProPheArgAl aAlaGlySerAspSerValTrpAlaGlyArgAsnProPheGlnlleArgThrThrHisArgAlaValLeuTyrVal SerSerCysValLeuGluHisLysCysValTyrSerIleArgLeuMetSerAlaLeu-297 g774 AMPHI Regions - AMPHI 16-AlaSerCysAlaSerValLeu-22 61-ValArgLeuSerAsnGluVal-67 90-ValGlnLysLeuAsp-94 115-ValGluThrAlaGlnAsnLeuTyrAsnGlnAlaLeuLysHisTyrGlnAsnGly-132 170-CysGluSerValIleGluIle-176 180-TyrAlaAsnArgPheLysAspSer-187 210-AlaArgAlaThrTrpArgSerLeuIleGlnThrTyrProGly-223 Antigenic Index - Jameson-Wolf 23-ProValProGluGlySerArgThrGluMetProThrGlnGluAsnAlaSerAspGlyIlePro-43 49-LeuGlnAspArgLeuAspTyrLeuGlu-57 59-LysIleValArgLeuSerAsnGluValGluMetLeuAsnGlyLysValLysAlaLeuGluHisThrLysIleH isProSerGlyArgThrTyrValGlnLysLeuAspAspArgLysLeuLysGlu-100 102-TyrLeuAsnThrGluGlyGlySerAla-llO 125-AlaLeuLysHisTyrGlnAsnGlyArgPhe-134 142-LysGlyAlaAspGlyGlyAspGlyGlySerIleAlaGln-154 162-GlnSerArgAlaArgMetGlyAsnCys-170 176-IleGlyGlyArgTyrAlaAsnArgPheLysAspSerProThrAla-190 198-GlyGluCysGlnTyr-202 204-LeuGlnGlnLysAspIleAla-210 221-TyrProGlySerProAlaAlaLysArgAlaAlaAlaAlaValArgLysArg-237 Hydrophilic Regions - Hopp-Woods 25-ProGluGlySerArgThrGluMetProThrGlnGluAsnAlaSerAsp-40 49-LeuGlnAspArgLeuAspTyrLeuGlu-57 59-LysIleValArgLeuSerAsnGluValGluMetLeuAsnGlyLysValLysAlaLeuGluHisThrLysIleH isProSerGly-86 89-TyrValGlnLysLeuAspAspArgLysLeuLysGlu-100 142-LysGlyAlaAspGlyGlyAspGlyGlySerIleAlaGln-154 163-SerArgAlaArgMetGlyAsn-169 180-TyrAlaAsnArgPheLysAspSerProThrAla-190 198-GlyGluCysGlnTyr-202 204-LeuGlnGlnLysAspIleAla-210 225-ProAlaAlaLysArgAlaAlaAlaAlaValArgLysArg-237 g900-2 AMPHI Regions - AMPHI 6-LeuGluAsnGlyThrHisSer-12 19-GluArgThrTyrProGluProCysHisGluCysLysTerTerLeuArgArgIle-36 43-AlaPheAlaGlnPheCys-48 68-ValGlyLysHisLeuArgLysPheArgArgPheArgArgArgGly-82 94-ValGlyLeuPheArgLeuAlaArgLeuPheHisValGlyAsnAspPheValAspArgPheLeuGlyPhePhe- 117 130-PheGlyHisPheAlaSer-135 153-GlyGluGluPheLeuGluThrValValGluAlaAlaGlyAsnValAlaArgHisPheAspValLeuAspLeu -176 193-SerHisGlnAsnArgIle-198 230-HisGlnThrLeuGlyGlyAspAlaGly-238 242-ValGlnLeuHisHisPheGly-248 265-GlyLysProSerGlyGlyAsnGlyLeuGlyGlyLeuValAsn-278 311-AspGlyAlaAspValValAlaGlnMet-319 Antigenic Index - Jameson-Wolf 1-GlyTerProGluProLeuGluAsnGlyThrHisSerGluProThrGluMetAsxGluArgThrTyrProGluPr oCysHisGluCysLysTerTerLeuArgArgIleArgGlyGlnCys-40 50-PheGlyValAspPheArgArgArgLysPhePhe-60 70-LysHisLeuArgLysPheArgArgPheArgArgArgGlyGluGlyPheIle-86 88-PheLyεGlnArgAla-92 105-ValGlyAsnAspPheValAsp-lll 120-PheProLysArgAsnGlyIleAla-127 135-SerValGlnThrAspGlnGluPhe-142 150-PheGlyGlnGlyGluGluPheLeu-157 163-AlaAlaGlyAsnVal-167 177-ValAlaProAspGlyAspPheValGly-185 189-GlnAsnValGlySerHisGlnAsnArgIleThrGluGlnThrHisPhe-204 233-LeuGlyGlyAspAlaGlyGlnAsnPro-241 261-ValGluSerAlaGlyLysProSerGlyGlyAsnGly-272 289-ValValIleGlyGluGluGluGluGlyPhe-298 302-ValLeuArgArgAlaAspGlyGlyAlaAspGlyAlaAsp-314 319-MetArgGlyAlaGlyGlyGlyTyrAlaGly-328 343-MetProSerGluArgGluLysMetArgArg-352 361-ProAlaAspAsnArg-365 Hydrophilic Regions - Hopp-Woods l-GlyTerProGluProLeuGluAsnGlyThrHisSerGluProThrGluMetAsxGluArgThrTyrPro-23 25-ProCysHisGluCysLysTerTerLeuArgArgl1eArgGly-38 53 -AspPheArgArgArgLysPhePhe-60 70-LysHisLeuArgLysPheArgArgPheArgArgArgGlyGluGly-84 121-ProLysArgAsnGly-125 137-GlnThrAspGlnGluPhe-142 152-GlnGlyGluGluPheLeu-157 177-ValAlaProAspGlyAspPheValGly-185 194-HisGlnAsnArgIleThrGlu-200 233-LeuGlyGlyAspAlaGlyGln-239 263-SerAlaGlyLysProSerGly-269 289-ValValIleGlyGluGluGluGluGlyPhe-298 302-ValLeuArgArgAlaAspGlyGlyAlaAspGlyAlaAsp-314 343-MetProSerGluArgGluLysMetArgArg-352 g902 AMPHI Regions - AMPHI 56-AlaValGlyHisPheAlaAspValProAla-65 77-LeuThrIleLysArgValHisGly-84 128-AspAlaValGlyGlyGly-133 190-PheGlyAspPheGlyAsp-195 216-AlaArgArgLeuAsp-220 241-AspValAlaHisPheLeuGlyGlyAla-249 266-ArgArgIleArgHisLeuPheGlyVal-274 288-GlyLysIleThrAlaValGlnGlyPheSer-297 318-ArgProThrGluAlaAlaGluGlyPhe-326 334-ArgLysCysAspGlyValValAspLysIleThrAlaAspVal-347 Antigenic Index - Jameson-Wolf l-MetProSerGluProGluArgArgHisGlyAsnThrAla-13 26-PheSerGlyLysProPheLysIleThrGly-35 38-ValValLeuArgArgArgIleValGln-46 72-AlaHisThrAspGlyLeuThrIleLysArgValHisGly-84 89-GlnAsnGlyGlySer-93 97-GlnThrGlnGlyArgArgXxxAsn-104 113-IleAlaGluLysProArgProAlaLeu-121 134-LeuPheGluAspGlyGlyGlyPheLeuArgArgSerAspValAlaValAspProGlyArgAspValGln-15 6 175-ArgAlaArgAlaProValAsnGlyLysGlyGlyAsn-186 192-AspPheGlyAspGlyGlyGln-198 210-PheGluGlyAsnGlyTyrAlaArgArgLeuAspHisArgLeuGlnAsnGlyGlyAsnGlnArgLeu-231 252-IleAspValAspAspLeuArgProGluSerAspValValThrArgArgIleArg-269 277-GlyAsnLeuHisGlyAsnAspAla-284 296-PheSerGlyIleProGluArgArgIleAla-305 310-AlaHisArgProThrCysAlaLysArgProThrGluAlaAlaGlu-324 330-AlaArgHisArgArgLysCysAspGlyValValAspLysIleThrAla-345 347-ValHisAsnGlyProAlaPheGlnLysSerAla-357 Hydrophilic Regions - Hopp-Woods 1-MetProSerGluProGluArgArgHisGlyAsn-ll 29-LysProPheLysIleThrGly-35 38-ValValLeuArgArgArgIleValGln-46 77-LeuThrIleLysArgValHisGly-84 99-GlnGlyArgArgXxxAsn-104 113-IleAlaGluLysProArgProAlaLeu-121 134-LeuPheGluAspGlyGlyGlyPheLeuArgArgSerAspValAlaValAspProGlyArgAspValGln-15 6 175-ArgAlaArgAlaProValAsnGlyLysGlyGlyAsn-186 214-GlyTyrAlaArgArgLeuAspHisArgLeuGlnAsn-225 252-IleAspValAspAspLeuArgProGluSerAspValValThrArgArgIleArg-269 299-IleProGluArgArgIleAla-305 313-ProThrCysAlaLysArgProThrGluAlaAlaGlu-324 330-AlaArgHisArgArgLysCysAspGlyValValAspLysIleThrAla-345 g904 AMPHI Regions - AMPHI 1-MetMetGlnHisAsnArgPhePheAlaValGlyAlaGlyGlyAspAspGlyAspArgArgAlaAlaAspPhePh eAsnProPheGlnlleCysPheGlylleGlyArgGlnCysValValAlaPheHisAlaAspSerArgPheAlaPro AlaGlyHisGlyPheValAsnArgPheAlaGlyPheHisArglleArgThrAlaArgGlnAspValGlyPheAlaA laAlaTrpGlnPheValAlaAspAlaAspIleAspGlyPheAsnAlaValHisTyrlleGluPheGlyAsnAlaHi sThrGlyAsnAlaValAspLeuAspGlyAlaPheGlnGlyGlyGlylleLysProAlaAlaAlaAlaArgAlaAla GlyTyrArgThrGluPheValSerAlaLeuArgGlnThrCysAlaTyrPheValGluGlnPheGlyArgGluArgA laArgThrAspAlaArgGlylleGlyPheAspAspAlaGlnAsnllelleGlnHisLeuArgThrTyrAlaArgAl aCysArgSerArgAlaGlyGluThrValGlyArgGlyAsnGluGlyValSerAlaValValAspValGlnGlnArg ThrLeuArgAlaPheLysGlnGlnPhePheAlaValPheValPhePheValGlnHisAlaGlyHisValGlyAsnH isArgArgAsnAlaArgArgAspPhePheAspAsnArgHisHisValPheArgPheAsnArgSerGlyValMetGl nValLeuGluLeuAspValVallleGlyLysAspGlylleGlnPhePheThrGlnPhePheArgMetGlnGlnlle GlyGlyAlaAsnGlyAlaAlaCysHisPheValPheValGlyArgAlaAspAlaAlaAlaGlyArgAlaAspPheA laPheAlaAlaArgCysPheAlaGlyLeuValGluArgAspValValArgGlnAspGlnArgAlaGlyArgArgAs pPheGlnThrAlaPheAspValPheHisAlaCysArgValGlnLeuValAspPheAlaGlnGlnGlyPheGlyGly AsnAspAsnAlaArgThrAspGluAlalleGlnSerPheValGlnAspThrAlaArgAsnGlnAlaGlnAsnGlyP hePheAlaAlaAspAspGlnGlyMetAlaArglleValAlaAlaLeuGluAlaHisAspAlaAlaGlyPhePheAr gGlnProValAsnAspPheThrPheThrLeuValAlaProLeuCysAlaAspTyrTyrAsnllePheSerHisSer HisIleThrTyrArgTyr-436 Antigenic Index - Jameson-Wolf 1-MetMetGlnHisAsnArgPhePheAlaValGlyAlaGlyGlyAspAspGlyAspArgArgAlaAlaAspPhePh eAsnProPheGlnlleCysPheGlylleGlyArgGlnCysValValAlaPheHisAlaAspSerArgPheAlaPro AlaGlyHisGlyPheValAsnArgPheAlaGlyPheHisArglleArgThrAlaArgGlnAspValGlyPheAlaA laAlaTrpGlnPheValAlaAspAlaAspIleAspGlyPheAsnAlaValHisTyrlleGluPheGlyAsnAlaHi sThrGlyAsnAlaValAspLeuAspGlyAlaPheGlnGlyGlyGlylleLysProAlaAlaAlaAlaArgAlaAla GlyTyrArgThrGluPheValSerAlaLeuArgGlnThrCysAlaTyrPheValGluGlnPheGlyArgGluArgA laArgThrAspAlaArgGlylleGlyPheAspAspAlaGlnAsnllelleGlnHisLeuArgThrTyrAlaArgAl aCysArgSerArgAlaGlyGluThrValGlyArgGlyAsnGluGlyValSerAlaValValAspValGlnGlnArg ThrLeuArgAlaPheLysGlnGlnPhePheAlaValPheValPhePheValGlnHisAlaGlyHisValGlyAsnH isArgArgAsnAlaArgArgAspPhePheAspAsnArgHisHisValPheArgPheAsnArgSerGlyValMetGl nValLeuGluLeuAspValVallleGlyLysAspGlylleGlnPhePheThrGlnPhePheArgMetGlnGlnlle GlyGlyAlaAsnGlyAlaAlaCysHisPheValPheValGlyArgAlaAspAlaAlaAlaGlyArgAlaAspPheA laPheAlaAlaArgCysPheAlaGlyLeuValGluArgAspValValArgGlnAspGlnArgAlaGlyArgArgAs pPheGlnThrAlaPheAspValPheHisAlaCysArgValGlnLeuValAspPheAlaGlnGlnGlyPheGlyGly AsnAspAsnAlaArgThrAspGluAlalleGlnSerPheValGlnAspThrAlaArgAsnGlnAlaGlnAsnGlyP hePheAlaAlaAspAspGlnGlyMetAlaArglleValAlaAlaLeuGluAlaHisAspAlaAlaGlyPhePheAr gGlnProValAsnAspPheThrPheThrLeuValAlaProLeuCysAlaAspTyrTyrAsnllePheSerHisSer HisIleThrTyrArgTyr-436 Hydrophilic Regions - Hopp-Woods 1-MetMetGlnHisAsnArgPhePheAlaValGlyAlaGlyGlyAspAspGlyAspArgArgAlaAlaAspPhePh eAsnProPheGlnlleCysPheGlylleGlyArgGlnCysValValAlaPheHisAlaAspSerArgPheAlaPro AlaGlyHisGlyPheValAsnArgPheAlaGlyPheHisArglleArgThrAlaArgGlnAspValGlyPheAlaA laAlaTrpGlnPheValAlaAspAlaAspIleAspGlyPheAsnAlaValHisTyrlleGluPheGlyAsnAlaHi sThrGlyAsnAlaValAspLeuAspGlyAlaPheGlnGlyGlyGlylleLysProAlaAlaAlaAlaArgAlaAla GlyTyrArgThrGluPheValSerAlaLeuArgGlnThrCysAlaTyrPheValGluGlnPheGlyArgGluArgA laArgThrAspAlaArgGlylleGlyPheAspAspAlaGlnAsnllelleGlnHisLeuArgThrTyrAlaArgAl aCysArgSerArgAlaGlyGluThrValGlyArgGlyAsnGluGlyValSerAlaValValAspValGlnGlnArg ThrLeuArgAlaPheLysGlnGlnPhePheAlaValPheValPhePheValGlnHisAlaGlyHisValGlyAsnH isArgArgAsnAlaArgArgAspPhePheAspAsnArgHisHisValPheArgPheAsnArgSerGlyValMetGl nValLeuGluLeuAspValVallleGlyLysAspGlylleGlnPhePheThrGlnPhePheArgMetGlnGlnlle GlyGlyAlaAsnGlyAlaAlaCysHisPheValPheValGlyArgAlaAspAlaAlaAlaGlyArgAlaAspPheA laPheAlaAlaArgCysPheAlaGlyLeuValGluArgAspValValArgGlnAspGlnArgAlaGlyArgArgAs pPheGlnThrAlaPheAspValPheHisAlaCysArgValGlnLeuValAspPheAlaGlnGlnGlyPheGlyGly AsnAspAsnAlaArgThrAspGluAlalleGlnSerPheValGlnAspThrAlaArgAsnGlnAlaGlnAsnGlyP hePheAlaAlaAspAspGlnGlyMetAlaArglleValAlaAlaLeuGluAlaHisAspAlaAlaGlyPhePheAr gGlnProValAsnAspPheThrPheThrLeuValAlaProLeuCysAlaAspTyrTyrAsnllePheSerHisSer HisIleThrTyrArgTyr-436 g907-2 AMPHI Regions - AMPHI 6-LeuGluAsnGlyThrHisSer-12 19-GluArgThrTyrProGluProCysHisGluCysLysTerTerMetLysLysProThrAspThrLeuPro-41 74-AspAspValAlaSerValMetArgSer-82 98-LysGluGlyGluArgTrpLeuSerAlaMetSer-108 110-ArgLeuAlaArgPheValPro-116 161-GlyAlaArgGlyLeu-165 174-AsnTyrIleGlyLysProAlaHis-181 197-LeuArgHisTyrArgAsnLeuGluLysGlyAspIleValArgAlaLeuAlaArgPheAsnGly-217 Antigenic Index - Jameson-Wolf 1-GlyTerProGluProLeuGluAsnGlyThrHisSerGluProThrGluMetAsxGluArgThrTyrProGluPr oCysHisGluCysLysTerTerMetLysLysProThrAspThrLeuPro-41 44-LeuGlnArgArgArgLeuLeu-50 65-GlyAlaGlnArgGluGluThrLeuAlaAspAspValAlaSer-78 83-SerValGlySerValAsnProProArgLeuValPheAspAsnProLysGluGlyGluArgTrp-103 113-ArgPheValProAspGluGlyGluArgArgArgLeu-124 129-GlnTyrGluSerSerArgAlaGlyLeu-137 147-GluValGluSerAlaPhe-152 174-AsnTyrIleGlyLysProAlaHisAsn-182 187-ArgThrAsnLeuArgTyrGly-193 200-TyrArgAsnLeuGluLysGlyAspIleVal-209 216-AsnGlySerLeuGlySerAsnLysTyrProAsnAla-227 232-TrpArgAsnArgTrpGlnTrp-238 Hydrophilic Regions - Hopp-Woods l-GlyTerProGluProLeuGluAsnGlyThrHisSerGluProThrGluMetAsxGluArgThrTyrPro-23 25-ProCysHisGluCysLysTerTerMetLysLysProThrAsp-38 44-LeuGlnArgArgArgLeuLeu-50 65-GlyAlaGlnArgGluGluThrLeuAlaAspAspValAlaSer-78 92-LeuValPheAspAsnProLysGluGlyGluArgTrp-103 115-ValProAspGluGlyGluArgArgArgLeu-124 131-GluSerSerArgAlaGlyLeu-137 147-GluValGluSerAlaPhe-152 201-ArgAsnLeuGluLysGlyAspIleVal-209 g908 AMPHI Regions - AMPHI 24-ThrAlaAlaGluLeu-28 125-ThrAspCysTyrArgSerTyrAspValLeuAspValSerGluPheSerHisPheSer-143 Antigenic Index - Jameson-Wolf l-LysSerArgLeuSerArgTyrLysGlnAsnLysLeu-12 30-GlyIleAsnLysAsnThrAla-36 49-GlnAsnGlyProHis-53 57-PheAspGlyGluValGluAlaAspGluSerTyrPheGlyGlyGlnArgLysGlyLysArgGlyArgGlyAlaA laGlyLys-83 89-LeuLeuLysArgAsnGlyLysVal-96 113-IleArgGluGlnValLysProAspSerIleVal-123 125-ThrAspCysTyrArgSerTyrAsp-132 159-ArgThrThrLysProTyr-164 Hydrophilic Regions - Hopp-Woods 1-LysSerArgLeuSerArgTyrLysGlnAsnLys-ll 57-PheAspGlyGluValGluAlaAspGluSerTyr-67 70-GlyGlnArgLysGlyLysArgGlyArgGlyAlaAlaGly-82 90-LeuLysArgAsnGlyLys-95 113-IleArgGluGlnValLysProAspSer-121 g909 AMPHI Regions - AMPHI 24-GlnAspGlySerGly-28 Antigenic Index - Jameson-Wolf 22-ThrTyrGlnAspGlySerGlyLysThrAlaValArgAlaLysCysSerThrGlyThrPro-41 45-GlnAspGlyArgGlySerLysLysValAspCysAspGluTyrGlyGlyGluArgArgAlaValLeuArgAsnG lnLysArgGlyLysProAlaThrArgArgAlaAlaThr-81 83-GlyLysProSerPheArgAlaArgAspGlyGlyGlyArgValAsnArgAlaGluThrGlyGluGlyLysArgS erAlaArg-109 Hydrophilic Regions - Hopp-Woods 23-TyrGlnAspGlySerGlyLysThrAlaValArgAlaLysCysSerThr-38 46-AspGlyArgGlySerLysLysValAspCysAspGluTyrGlyGlyGluArgArgAlaValLeuArgAsnGlnL ysArgGlyLysProAlaThrArgArgAlaAlaThr-81 85-ProSerPheArgAlaArgAspGlyGlyGlyArgValAsnArgAlaGluThrGlyGluGlyLysArgSerAlaA rg-109 g910 AMPHI Regions - AMPHI 22-SerAlaGluArgGlnIle-27 39-LysAlaValLysMetLeuGlu-45 69-AlaTyrLysAspGlyArg-74 Antigenic Index - Jameson-Wolf 19-AlaGlyAspSerAlaGluArgGlnIleTyrGlyAspProHisPheGluGlnAsnArgThrLysAlaValLysM etLeuGluGlnArgGlyTyrGln-50 53-AspValAspAlaAspAspTyrTrpGlyLysProValLeuGlu-66 68-GluAlaTyrLysAspGlyArgGluTyrAsp-77 83-ProAspLeuLysIleIleLysGluGlnLeuAspArg-94 Hydrophilic Regions - Hopp-Woods 21-AspSerAlaGluArgGlnIleTyr-28 31-ProHisPheGluGlnAsnArgThrLysAlaValLysMetLeuGluGlnArgGly-48 53-AspValAspAlaAspAspTyrTrp-60 68-GluAlaTyrLysAspGlyArgGluTyrAsp-77 86-LysIleIleLysGluGlnLeuAspArg-94 g911 AMPHI Regions - AMPHI 6-LeuGluPheTrpValGlyLeuPhe-13 43-ValTyrAlaAspPheGlyAspIleGly-51 97-ValSerAlaGlnIle-101 118-GlyAspThrGluAsnLeuAla-124 140-AsnLeuIleGlyLysPheMetThrSerPhe-149 Antigenic Index - Jameson-Wolf l-Me LysLysAsnIle-5 35-GlyGlySerAspLysThrTyr-41 48-GlyAspIleGlyGlyLeuLysValAsnAlaProValLys-60 74-LeuAspProLysSerTyrGlnAlaArgValArgLeuAspLeuAspGlyLysTyrGlnPheSerSerAspVal- 97 103-ThrSerGlyLeuLeuGly-108 115-GlnGlnGlyGlyAspThrGluAsn-122 149-PheAlaGluLysAsnAlaGluGlyGlyAsnAlaGluLysAlaAlaGlu-164 Hydrophilic Regions - Hopp-Woods l-MetLysLysAsnIle-5 36-GlySerAspLysThr-40 74-LeuAspProLysSerTyrGlnAlaArgValArgLeuAspLeuAspGly-89 116-GlnGlyGlyAspThrGluAsn-122 149-PheAlaGluLysAsnAlaGluGlyGlyAsnAlaGluLysAlaAlaGlu-164 g912 AMPHI Regions - AMPHI 23-SerProAlaAspAlaValGlyGlnIle-31 63-AspPheGlnArgMetThrAlaLeuAlaValGlyAsnProTrpArgThrAlaSerAspAlaGlnLys-84 89-LysGluPheGlnThrLeu-94 169-TyrArgAsnGlnPheGlyGluIleIleLysAlaLysGlyIleAspGlyLeuIleAla-187 Antigenic Index - Jameson-Wolf l-ValLysLysSerSer-5 23-SerProAlaAspAla-27 31-IleArgGlnAsnAlaThrGln-37 42-LeuLysSerGlyAspAlaAlaSerAlaArgProLysAlaGluAla-56 74-AsnProTrpArgThrAlaSerAspAlaGlnLysGlnAlaLeuAlaLysGluPhe-91 104-LeuLysPheLysAsn-108 112-AsnValLysAspAsnProIleValAsnLysGlyGlyLysGluIleValVal-128 134-IleProGlyGlnLysProValAsnMet-142 146-ThrTyrGlnSerGlyGlyLysTyrArgThr-155 169-TyrArgAsnGlnPhe-173 177-IleLysAlaLysGlyIleAsp-183 189-LeuLysAlaLysAsnGlyGlyLys-196 Hydrophilic Regions - Hopp-Woods l-ValLysLysSerSer-5 31-IleArgGlnAsnAla-35 43-LysSerGlyAspAlaAlaSerAlaArgProLysAlaGluAla-56 78-ThrAlaSerAspAlaGlnLysGlnAlaLeuAlaLysGluPhe-91 104-LeuLysPheLysAsn-108 112-AsnValLysAspAsnProIleVal-119 121-LysGlyGlyLysGluIleValVal-128 177-IleLysAlaLysGlyIleAsp-183 189-LeuLysAlaLysAsnGlyGlyLys-196 g913 AMPHI Regions - AMPHI 22-GluThrArgProAlaAspProTyrGluGlyTyrAsnArgAlaValSerLysPheAsnAspGlnAla-43 53-ArgGlyTyrArgLysValThrProLys-61 66-GlyValSerAsnPhePheAsnAsnLeuArgAspValValSer-79 107-LeuGlyGlyLeuIleAspIleAlaGly-115 151-ValArgAspAlaLeuGlyThrGlyIleThrSerValTyr-163 193-AspLeuThrAspSerLeuAspGluAlaAla-202 240-LeuValGluSerAla-244 259-SerGluThrGlnAla-263 Antigenic Index - Jameson-WoIf l-MetLysLysThrAla-5 21-AlaGluThrArgProAlaAspProTyrGluGlyTyrAsnArgAlaValSerLysPheAsnAspGlnAlaAspA rgTyr-46 51-AlaAlaArgGlyTyrArgLysValThrProLysProValArgAla-65 87-LeuAspIleLysArgAlaSerGluAspLeuVal-97 117-GlyGlyValProAspAsnLysAsnThrLeuGlyAsp-128 132-SerTrpGlyTrpLysAsnSerAsn-139 149-SerThrValArgAspAlaLeu-155 163-TyrProProLysAsn-167 173-ProAlaGlyArgTrpGly-178 186-SerThrArgGluGlyLeuLeuAspLeuThrAspSerLeuAspGluAlaAlaIleAspLysTyrSerTyrThr ArgAspLeuTyrMet-214 216-ValArgAlaArgGlnThrGlyAlaThrProAlaGluGlyThrGluAspAsnIleAspIleAspIleAspGlu LeuValGluSerAlaGluThrGlyAlaAla-249 252-AlaValHisGluAspSerValSerGluThrGlnAlaGluAlaAlaGlyGluAlaGluThrGlnProGlyThr GlnPro-277 Hydrophilic Regions - Hopp-Woods l-MetLysLysThrAla-5 21-AlaGluThrArgProAlaAspProTyrGluGlyTyrAsn-33 35-AlaValSerLysPheAsnAspGlnAlaAsp-44 53-ArgGlyTyrArgLysValThrProLysProValArg-64 87-LeuAspIleLysArgAlaSerGluAspLeuVal-97 118-GlyValProAspAsnLysAsnThrLeu-126 150-ThrValArgAspAlaLeu-155 186-SerThrArgGluGlyLeuLeuAspLeuThrAspSerLeuAspGluAlaAlaIleAsp-204 216-ValArgAlaArgGlnThrGly-222 224-ThrProAlaGluGlyThrGluAspAsnIleAspIleAspIleAspGluLeuValGluSerAlaGluThrGly AlaAla-249 252-AlaValHisGluAspSerValSerGluThrGlnAlaGluAlaAlaGlyGluAlaGluThrGlnPro-273 g914-2 AMPHI Regions - AMPHI 6-LeuGlyIleLeuThrAlaCysAlaAlaMet-15 17-AlaPheAlaAspArgIleSerAspLeu-25 65-PheGlnLysThrPheGlu-70 81-GlnLysValArgGlnAlaCys-87 Antigenic Index - Jameson-Wolf 18-PheAlaAspArgIleSerAspLeuGluAlaArgLeuAlaGlnLeuGluHisArgValAlaValLeuGluSerG lyGlyAsnThrValLys-47 50-LeuPheGlySerAsnSer-55 64-ProPheGlnLysThrPheGluAlaSerAspArgAsnGluGlyValAlaArgGlnLysValArgGlnAlaCysA snArgGluThrSerAla-93 96-CysGlyAspGluAlaIleArgCysArgLysPheAsp-107 Hydrophilic Regions - Hopp-Woods 18-PheAlaAspArgIleSerAspLeuGluAlaArgLeuAlaGlnLeuGluHisArgValAlaVal-38 67-LysThrPheGluAlaSerAspArgAsnGluGlyValAlaArgGlnLysValArgGlnAlaCysAsnArgGluT hrSer-92 96-CysGlyAspGluAlaIleArgCysArgLysPheAsp-107 g915 AMPHI Regions - AMPHI 8-IleValAlaValPheAlaLeuSerAla-16 31-IleSerAspArgSerVal-36 69-ValLysGlnMetPheGlyTyrThrLysLeuProGluGluProLysGlyIleArgValIleTyrValThrAspM etGlyAsnValThrAspTrpThr-100 139-GlnAlaGluLysPhe-143 Antigenic Index - Jameson-Wolf 16-AlaCysArgGlnAlaGluGluAlaProProProLeuProArgGlnIleSerAspArgSerValGlyHisTyrC ysSerMetAsnLeuThrGluHisAsnGlyProLysAla-52 56-LeuAsnGlyLysProAspGlnProVal-64 75-TyrThrLysLeuProGluGluProLysGlyIle-85 92-AspMetGlyAsnValThrAspTrpThrAsnProAsnAlaAspThrGluTrpIleAspAlaLysLys-113 125-GlyMetGlyAlaGluAspAlaLeuProPheGlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGly GlyLysValValGly-153 155-AspAspMetProAsp-159 Hydrophilic Regions - Hopp-Woods 18-ArgGlnAlaGluGluAlaProProProLeu-27 30-GlnIleSerAspArgSerVal-36 46-GluHisAsnGlyProLys-51 58-GlyLysProAspGln-62 77-LysLeuProGluGluProLysGlyIle-85 103-AsnAlaAspThrGluTrpIleAspAlaLysLys-113 127-GlyAlaGluAspAlaLeu-132 135-GlyAsnLysGluGlnAlaGluLysPheAlaLysAspLysGlyGlyLys-150 155-AspAspMetProAsp-159 g917 AMPHI Regions - AMPHI 6-ProLeuAlaValLeuThrAlaLeuLeuLeu-15 35-GlnAsnValLeuLysIleTyrAsnTrpSerGluTyrValAspProGluThrValAlaAsp-54 99-IleLysAlaGlyAlaTyrGlnLysIleAspLysSer-110 124-ArgLeuMetAspGlyValAsp-130 152-ArgValLysLysAlaLeu-157 188-AspSerAlaAlaGlu-192 206-AsnSerSerAsnThrGluAspIleArgGluAlaThr-217 292-AlaLysAsnValAlaAsnAlaHisLysTyrIleAsnAspPheLeuAsp-307 325-LysProAlaArgAspLeuMetGluAsp-333 Antigenic Index - Jameson-Wolf 18-CysGlyGlySerAspLysProProAlaGluLysProAlaProAlaGluAsnGlnAsnVal-37 44-SerGluTyrValAspProGluThrValAlaAspPheGluLysLysAsnGlyIleLysValThr-64 68-TyrAspSerAspGluThrLeuGluSerLysValLeuThrGlyLysSerGlyTyrAsp-86 102-GlyAlaTyrGlnLysIleAspLysSerMetIleProAsnTyrLysHisLeuAsnProGluMetMetArgLeu MetAspGlyValAspProAspHisGluTyr-135 149-AsnThrGluArgValLysLysAlaLeuGlyThrAspLysLeuProAspAsnGln-166 171-PheAsnProGluTyr-175 179-LeuLysGlnCysGly-183 201-LeuGlyLysAsnProAsnSerSerAsnThrGluAspIleArgGluAlaThrAlaLeuLeuLysLysAsnArg ProAsnIleLysArgPheThrSerSerGlyPheIle-236 238-AspLeuAlaArgGlyAspThr-244 255-AsnIleAlaLysArgArgAlaGluGluAlaGlyGlyLysGluLysIleArgValMetMetProLysGluGly ValGly-280 287-ValIleProLysAspAlaLysAsnValAlaAsn-297 305-PheLeuAspProGluValSerAlaLysAsnGlyAsn-316 320-TyrAlaProΞerSerLysProAlaArgAspLeuMetGluAspGluPheLysAsnAspAsnThrIlePhePro SerGlyGluAspLeuLysAsn-350 368-GlnTrpGlnAspValLysAlaGlyLys-376 Hydrophilic Regions - Hopp-Woods 19-GlyGlySerAspLysProProAlaGluLysProAlaProAlaGluAsn-34 47-ValAspProGluThrValAlaAspPheGluLysLysAsnGlyIle-61 68-TyrAspSerAspGluThrLeuGluSerLysValLeuThr-80 105-GlnLysIleAspLysSerMet-lll 121-GluMetMetArgLeuMetAspGlyValAspProAspHisGluTyr-135 149-AsnThrGluArgValLysLysAlaLeuGlyThrAspLysLeuProAspAsnGln-166 204-AsnProAsnSerSerAsnThrGluAspIleArgGluAlaThrAlaLeuLeuLysLysAsnArgProAsnIle LysArgPheThr-231 238-AspLeuAlaArgGlyAspThr-244 255-AsnIleAlaLysArgArgAlaGluGluAlaGlyGlyLysGluLysIleArgValMetMetProLysGluGly -278 290-LysAspAlaLysAsnValAlaAsn-297 305-PheLeuAspProGluValSerAlaLysAsn-314 322-ProSerSerLysProAlaArgAspLeuMetGluAspGluPheLysAsnAspAsn-339 344-SerGlyGluAspLeuLysAsn-350 370-GlnAspValLysAlaGlyLys-376 g919 AMPHI Regions - AMPHI 8-SerAlaLeuTyrGlyIleAlaAlaAlaIleLeu-18 24-ArgSerIleGlnThrPheProGln-31 37-IleAsnGlyProAspArgProAlaGlyIleProAspProAlaGly-51 76-AspPheAlaLysSerLeuGln-82 98-GlnAspValCysAlaGlnAlaPheGlnThrProVal-109 118-PheGluArgTyrPheThr-123 133-LeuAlaGlyThrValThrGlyTyrTyrGlu-142 161-GlyIleProAspAspPheIleSerValPro-170 176-ArgGlyGlyLysAsnLeuValArgl1eArgGln-186 191-SerGlyThrIleAspAsnAlaGlyGlyThr-200 308-GlnGlyIleLysAlaTyrMetArgGlnAsnProGlnArgLeuAlaGluValLeu-325 348-AlaLeuGlyThrProLeuMetGlyGluTyrAlaGlyAlaIle-361 382-ArgLysAlaLeuAsnArg-387 Antigenic Index - Jameson-Wolf 1-Me LysLysHisLeuLeu-δ 21-CysGlnSerArgSerIleGln-27 30-ProGlnProAspThr-34 36-ValIleAsnGlyProAspArgProAlaGlyIleProAspProAlaGly-51 76-AspPheAlaLysSerLeuGln-82 87-GlyCysAlaAsnLeuLysAsnArgGlnGlyTrpGln-98 113-GlnAlaLysArgPhePhe-118 121-TyrPheThrProTrp-125 143-ProValLeuLysGlyAspGlyArgArgThrGluArgAlaArg-156 161-GlyIleProAspAspPheIle-167 173-AlaGlyLeuArgGlyGlyLysAsnLeuValArgIleArgGlnThrGlyLysAsnSerGlyThrIleAspAsn AlaGlyGlyThrHis-201 215-ThrAlaIleLysGlyArgPheGluGlySerArgPheLeuProTyrHisThrArgAsnGlnIleAsnGlyGly AlaLeuAspGlyLysAlaPro-245 250-AlaGluAspProValGlu-255 262-GlnGlySerGlyArgLeuLysThrProSerGlyLysTyrIleArg-276 278-GlyTyrAlaAspLysAsnGluHisPro-286 293-TyrMetAlaAspLysGlyTyrLeuLysLeuGlyGln-304 312-AlaTyrMetArgGlnAsnProGlnArgLeuAlaGlu-323 326-GlyGlnAsnProSer-330 337-LeuAlaGlySerGlyAsnGluGlyProVal-346 359-GlyAlaIleAspArgHisTyr-365 379-ProValThrArgLysAlaLeuAsn-386 393-AspThrGlySerAlaIleLysGlyAlaValArg-403 409-GlyTyrGlyAspGluAlaGlyGluLeuAlaGlyLysGlnLysThrThr-424 431-LeuProAsnGlyMetLysProGluTyrArgPro-441 Hydrophilic Regions - Hopp-Woods l-MetLysLysHisLeuLeu-6 38-AsnGlyProAspArgProAlaGlyIleProAspProAlaGly-51 90-AsnLeuLysAsnArgGlnGlyTrp-97 144-ValLeuLysGlyAspGlyArgArgThrGluArgAlaArg-156 175-LeuArgGlyGlyLysAsnLeuValArgIleArgGlnThrGlyLysAsnSerGlyThrIleAspAsnAlaGly -198 215-ThrAlaIleLysGlyArgPheGluGly-223 239-AlaLeuAspGlyLysAla-244 250-AlaGluAspProVal-254 265-GlyArgLeuLysThrProSer-271 279-TyrAlaAspLysAsnGluHis-285 317-AsnProGlnArgLeuAlaGlu-323 337-LeuAlaGlySerGlyAsnGluGlyPro-345 380-ValThrArgLysAlaLeuAsn-386 393-AspThrGlySerAlaIle-398 412-AspGluAlaGlyGluLeuAlaGlyLysGlnLysThr-423 434-GlyMetLysProGluTyrArgPro-441 g920-2 AMPHI Regions - AMPHI 43-GlyGluPheProGluLeuGluProIleAla-52 117-GlyIleLysGluMetProAsp-123 135-LysAsnIleValAsnVal-140 163-LeuAspAsnProAlaAsn-168 190-ThrValThrAlaThrPheAspGlyPheAspThrSerAspArgSerLys-205 212-GlnAlaPheSerAspSerThr-218 Antigenic Index - Jameson-WoIf 40-LeuGlyTyrGlyGluPheProGlu-47 49-GluProIleAlaLysAspArgLeu-56 66-ValThrGluLysGlyLysGluAsnMetIle-75 77-ArgGlyThrTyrAsnTyrGlnTyrArgSerAsnArgProValLysAspGlySerTyr-95 104-ThrPheTrpSerLysAsnLysAlaGlyTrp-H3 116-AlaGlyIleLysGluMetProAspAlaSerTyrCysGluGlnThrArgMetPheGlyLysAsnIleValAsn ValGlyHisGluSerAlaAspThr-147 152-LysProValGlyGlnAsnLeuGlu-159 162-ProLeuAspAsnProAla-167 173-GluArgPheLysVal-177 181-PheArgGlyGluProLeuProAsnAla-189 194-ThrPheAspGlyPheAspThrSerAspArgSerLysThrHisLysThrGluAla-211 213-AlaPheSerAspSerThrAspAspLysGlyGluValAsp-225 237-AsnValGluHisLysThrAspPheProAspGlnSerValCysGlnLysGlnAlaAsnTyrSer-257 Hydrophilic Regions - Hopp-Woods 49-GluProIleAlaLysAspArgLeu-56 66-ValThrGluLysGlyLysGluAsnMetIle-75 85-ArgSerAsnArgProValLysAspGlySer-94 107-SerLysAsnLysAlaGlyTrp-113 116-AlaGlyIleLysGluMetProAsp-123 128-GluGlnThrArgMetPheGly-134 142-HisGluSerAlaAsp-146 173-GluArgPheLysVal-177 196-AspGlyPheAspThrSerAspArgSerLysThrHisLysThrGluAla-211 213-AlaPheSerAspSerThrAspAspLysGlyGluValAsp-225 237-AsnValGluHisLysThrAspPheProAsp-246 248-SerValCysGlnLys-252 g921 AMPHI Regions - AMPHI 12-AlaValLeuSerGlyCysGlnSerIleTyrValProThrLeuThrGluIleProValAsn-31 33-IleAsnThrValLysThr-38 51-HisTrpAlaAspValAlaLysIleSerAspGlu-61 72-GlyLysMetThrLysValGlnAlaAlaGlnTyrLeuAsnAsnPheArgLys-88 98-AspSerMetTyrGluIleTyrLeuArg-106 126-GluAsnAlaLeuArgGlyTrpGlnGlnArgTrp-136 Antigenic Index - Jameson-Wolf 36-ValLysThrGluAlaProAlaLysGlyPheArg-46 56-AlaLysIleSerAspGluAlaThrArg-64 72-GlyLysMetThrLys-76 84-AsnAsnPheArgLysArgLeuValGlyArgAsnAlaValAspAspSerMet-lOO 107-SerAlaValAspSerGlnArgGlyGluIleAsnThrGluGlnSerLysLeuTyr-124 128-AlaLeuArgGlyTrpGlnGlnArgTrpLysAsnMetAspAlaLysProAspAsnProAla-147 Hydrophilic Regions - Hopp-Woods 36-ValLysThrGluAlaProAlaLysGlyPheArg-46 56-AlaLysIleSerAspGluAlaThrArg-64 86-PheArgLysArgLeuValGly-92 94-AsnAlaValAspAspSerMet-100 107-SerAlaValAspSerGlnArgGlyGluIleAsnThrGluGlnSerLysLeuTyr-124 136-TrpLysAsnMetAspAlaLysProAspAsn-145 g922 AMPHI Regions - AMPHI 16-LeuSerAlaCysThrAla-21 28-ArgAlaAsnGluAlaGlnAlaPro-35 66-ValArgArgPheValAspAsp-72 82-AlaGluTrpGlnAspPhePheAspLys-90 98-ValLysIleMetHis-102 138-AspAspValAlaGln-142 166-GlySerPheArgValAlaAspAlaLeu-174 190-LysGluLeuValGluLeuLeuLysLeuAla-199 216-AlaMetGlyMetPro-220 239-HisArgAspIleTrpGlyAsnValGlyAspValAlaAlaSerValAlaAsnTyrMetLysGlnHis-260 292-ArgThrValAlaAspLeuLysAlaTyr-300 329-TyrLeuGlyLeuAsnAsnPheTyrThr-337 Antigenic Index - Jameson-Wolf l-MetGluLysArgLysIleLeu-7 22-MetGluAlaArgThrProArgAlaAsnGluAlaGlnAlaProArgAlaAspGluMetLysLysGluSerArgP roAlaPhe-48 55-ValSerAspSerGlyPhe-60 64-AlaAsnValArgArgPheValAspAspGluValGlyLysGlyAspPheΞerGln-81 101-MetHisArgProSerThrSerArgPro-109 114-ArgThrGlyAsnSerGlyArgAlaLysPheHisGly-125 127-ArgArgPheTyrAlaGluAsnArgAlaValIleAspAspValAlaGlnLysTyrGlyVal-146 157-IleGluThrAsnTyrGlyLysAsnThrGlySer-167 180-AspTyrProArgArgAlaGlyPhePhe-188 197-LysLeuAlaLysGluGluGlyGlyAsp-205 223-MetProSerSerTyrArgLysTrpAlaValAspTyrAspGlyAspGlyHisArgAspIle-242 260-HisGlyTrpArgThrGlyGlyLysMet-268 275-AlaProGlyAlaAsp-279 284-IleGlyGluLysThrAlaLeu-290 304-ProGlyGluThrLeuAlaAspAspGluLysAlaVal-315 320-GluThrAlaProGly-324 351-ValArgAspIleAlaAsnSerLeuGlyGlyProGlyLeu-363 Hydrophilic Regions - Hopp-Woods l-MetGluLysArgLysIleLeu-7 22-MetGluAlaArgThrProArgAlaAsnGluAlaGlnAlaProArgAlaAspGluMetLysLysGluSerArgP roAlaPhe-48 64-AlaAsnValArgArgPheValAspAspGluValGlyLysGlyAspPheSerGln-81 116-GlyAsnSerGlyArgAlaLyεPheHisGly-125 127-ArgArgPheTyrAlaGluAsnArgAlaValIleAspAspValAlaGln-142 160-AsnTyrGlyLysAsnThrGly-166 181-TyrProArgArgAlaGlyPhePhe-188 197-LysLeuAlaLysGluGluGlyGlyAsp-205 234-TyrAspGlyAspGlyHisArgAspIle-242 284-IleGlyGluLysThrAlaLeu-290 307-ThrLeuAlaAspAspGluLysAlaVal-315 351-ValArgAspIleAla-355 g923-2 AMPHI Regions - AMPHI 9-ProMetAlaCysAlaAlaPheLeu-16 26-LeuGlyAlaCysTyrAlaIleLeuSerLeuTyrAla-37 63-ProAlaLeuPheGlyGlyTrpThrGly-71 Antigenic Index - Jameson-Wolf 43-IleAspLysArgArgAlaValArgGlyLysArgArgIleProGluHisArgLeu-60 7 -ArgMetPheArgHisLysThrAlaLysLysArgPhe-88 Hydrophilic Regions - Hopp-Woods 43-IleAspLysArgArgAlaValArgGlyLysArgArgIleProGluHisArgLeu-60 77-ArgMetPheArgHisLysThrAlaLysLysArgPhe-88 g925-l AMPHI Regions - AMPHI 115-LysCysGlyGlnThrAlaGln-121 154-PheAspGluLeuGlu-158 Antigenic Index - Jameson-Wolf 16-GlyCysGlyLysAspAlaGlyGlyTyrGluGlyTyrTrpArgGluLysSerAspLysLysGluGlyValIleA laValLysLysLysGlyAsnTyrPhe-48 56-ThrGlyLysGluGluSerLeuLeuLeuSerGluLysAspGlyAla-70 74-AsnThrGlyl1eGly-78 80-IleProIleLysLeuSerAspAspGlyLysGluLeuTyrValGluArgArgArgTyrValLysThrAspAlaA laMetLysAspLysIleIleAlaHisGlnLysLysCysGlyGlnThr-119 124-LeuAspAlaArgAsnAlaLeuProSerAsnGlnThrTyrGlnGlnArgGlnAlaAla-142 144-GluGlnLeuLysArgArgPheGluAlaGluPheAspGluLeuGluLysGluIleLysCysAsnGlyLysPro Thr-168 Hydrophilic Regions - Hopp-Woods 17-CysGlyLysAspAlaGlyGly-23 27-TyrTrpArgGluLysSerAspLysLysGluGlyValIleAlaValLysLysLysGly-45 56-ThrGlyLysGluGluSerLeuLeuLeuSerGluLysAspGlyAla-70 80-IleProIleLysLeuSerAspAspGlyLysGluLeuTyrValGluArgArgArgTyrValLysThrAspAlaA laMetLysAspLysIleIleAlaHisGlnLysLysCysGlyGln-118 124-LeuAspAlaArgAsnAlaLeu-130 136-TyrGlnGlnArgGlnAlaAla-142 144-GluGlnLeuLysArgArgPheGluAlaGluPheAspGluLeuGluLysGluIleLysCysAsnGlyLys-16 6 g926 AMPHI Regions - AMPHI 29-ProSerGluHisIleSerSerPhe-36 72-LeuGlySerThrLeuGlyGln-78 98-AlaGluGlyThrGluAspLeuSerArgGln-107 Antigenic Index - Jameson-Wolf 19-LeuProGlnAsnAsnGluAsnLeuTrpGlnProSerGluHisIleSer-34 37-AlaAlaGluGlyArgLeuAlaValLysAlaGluGlyLyεGlySerTyrAla-53 70-ThrProLeuGlySer-74 79-LeuCyεGlnAspArgAspGlyAlaLeu-87 89-ValAspGlyLysGlyAsnValTyr-96 98-AlaGluGlyThrGluAspLeuSerArgGln-107 123-GluGlyArgArgValAlaGlyAlaProTyrArgIleArgSerAspGlyIleLeu-140 143-TyrGlyTrpThrIleGlyGlnAsnCysArgGlnTrpGly-155 157-SerProAsnValAlaThrGlu-163 Hydrophilic Regions - Hopp-Woods 37-AlaAlaGluGlyArgLeuAlaValLysAlaGluGlyLysGlySer-51 80-CysGlnAspArgAspGlyAlaLeu-87 89-ValAspGlyLysGly-93 99-GluGlyThrGluAspLeuSerArg-106 123-GluGlyArgArgValAla-128 132-TyrArgIleArgSerAspGlyIleLeu-140 g927 AMPHI Regions - AMPHI 13-LeuLeuThrAlaCyε-17 48-SerTyrAspValThrArgTyrPheTyrLysGlu-58 120-LysGlyTrpGlnGlnAlaLeuPro-127 145-AsnProLysGlnIleArgAspTrpAsnAspLeuAlaLysAspGly-159 195-LysLeuValAlaSerIleLeu-201 Antigenic Index - Jameson-Wolf 17-CysSerProAlaAlaAspSerAsnHisProSerGlyGlnAsnAlaProAlaAsnThrGluSerAspGlyLyεA snIle-42 65-GlyThrTyrGlnSerGluHisProGlyThrSer-75 81-SerHisGlyGlyPheSer-86 104-AsnGlnSerSerAspIleAspLeuLeuGluLysXxxGlyLeuVal-118 126-LeuProAspHisAlaAlaProTyrThr-134 142-ArgLysAsnAsnProLysGlnlleArgAspTrpAsnAspLeuAlaLysAspGlyVal-160 165-AlaLysThrSerGlyAsnGlyArg-172 183-LeuLysAlaAsnAsnGlyAsnGluGlnGluAlaGlnLys-195 201-LeuLysAsnThrProValPheGluAsnGlyGlyArgXxxProProProProProSerHisAsnAlaThrSer -224 229-SerLeuLeuLysThrLysProThrThrSerAlaLysAsn-241 Hydrophilic Regions - Hopp-Woods 19-ProAlaAlaAspSerAsnHisProSer-27 33-AlaAsnThrGluSerAspGlyLysAsn-41 68-GlnSerGluHisProGly-73 105-GlnSerSerAspIleAspLeuLeuGluLysXxxGlyLeuVal-118 142-ArgLysAsnAsnProLysGlnIleArgAspTrpAsnAspLeuAlaLysAspGlyVal-160 167-ThrSerGlyAεnGly-171 185-AlaAsnAsnGlyAsnGluGlnGluAlaGlnLys-195 209-AsnGlyGlyArgXxxProProPro-216 231-LeuLysThrLysProThrThrSerAlaLysAsn-241 g929 AMPHI Regions - AMPHI 25-ValProAspGlyValLys-30 34-TrpThrLeuLeuAlaMetPheValGlyValIleAlaAlaIleIleGly-49 53-ProLeuGlyAlaLeuSer-58 76-GlyAlaAlaMetSerAspAlaLeuSerAlaPhe-86 155-HisProIleMetGlnSerIleAlaGlySerTyrGlySerAsnProAlaLys-171 180-TyrLeuAlaLeuVal-184 187-HisSerAsnProIle-191 204-ProLeuIleValAsnLeuIleAlaGluAεnLeuGly-215 233-GlyValIleAlaPhePhe-238 265-ArgLeuSerGluMetGlyLys-271 280-AlaValIlePheGlyIle-285 355-LeuGlyLeuIleLysTrpPheSerGlyValLeuAlaGluSerValGlyGlyLeu-372 398-ThrAlaHisIleThrAlaMetPheGlyAlaPheLeuAla-410 452-TyrThrThrMetGlyGluTrpTrp-459 469-AεnPheLeuIlePheSerValIleGlySerIleTrpTrpLyεValLeuGlyTyr-486 Antigenic Index - Jameson-Wolf 25-ValProAspGlyValLysProGln-32 71-ThrAlaAspLysProGlyAlaAlaMet-79 122-GlyArgLysThrLeuGlylle-128 143-ThrProSerAsnThrAlaArgGlyGlyGly-152 163-GlySerTyrGlySerAsnProAlaLysGlyThrGluGlyLysMetGlyLys-179 187-HisSerAsnProIleSer-192 213-AsnLeuGlySerSerPhe-218 248-TyrProProGluIleLysGluThrProAsn-257 261-PheAlaLysAspArgLeuSerGluMetGlyLysMetSerAlaAspGluIle-277 328-AspValLeuLysGluLysSerAlaTrp-336 Hydrophilic Regions - Hopp-Woods 71-ThrAlaAspLysProGlyAlaAlaMet-79 146-AsnThrAlaArgGly-150 168-AsnProAlaLysGlyThrGluGlyLysMetGlyLys-179 250-ProGluIleLysGluThrProAsn-257 261-PheAlaLysAspArgLeuSerGluMetGlyLysMetSerAlaAspGluIle-277 328-AspValLeuLysGluLysSerAlaTrp-336 g930-l AMPHI Regions - AMPHI 6-AlaGlyAspIleAsnGlnIleMetSerLeu-15 30-IleLeuAlaAlaPro-34 48-ProGlyTyrLeuArgSerIleArgIle-56 82-AspLeuLeuAsnLeuArgAsp-88 96-LeuLysCysLeuPro-100 163-SerAspMetPheTyr-167 171-GlyArgSerIleGlyGly-176 216-ArgTyrHisGlnAlaValSerGlyLeuSerGluValTyrAsp-229 283 -TrpLeuAlaGluLeuSerHis-289 308-ThrGlyMetLysAspAlaLeuArgAlaProGluGluAlaPheGlyGluGly-324 355-HisAlaGlnTrpAsnLys-360 457-LeuLysLysProGluTyrPhe-463 Antigenic Index - Jameson-Wolf l-GlyLysCysLeuHisAlaGlyAsp-8 34-ProGlnAspLeuAsnSerGlyLysLeu-42 54-IleArgIleAspArgSerAsnAspAspGlnThrHisAlaGlyArgIleAla-70 74-AsnLysPheProThrArgSerAsnAspLeuLeuAsn-85 87-ArgAspLeuGluGlnGlyLeuGluAsn-95 102-AlaGluAlaAspLeu-106 110-ProValGluArgGluProAsnGlnSerAsp-119 136-GlyMetAspAsnSerGlySerGluAlaThrGlyLysTyrGlnGly-150 156-AlaAspAsnProPheGlyLeu-162 170-TyrGlyArgSerIleGlyGlyThrProAspGluGluAsnPheAspGlyHisArgLysGluGlyGlySerAsn -193 212-HisAsnGlyTyrArg-216 226-GluValTyrAspTyrAsnGlyLysSerTyrAsnThrAspPheGlyPhe-241 245-LeuTyrArgAspAlaLysArgLysThrTyrLeu-255 260-TrpThrArgGluThrLysSerTyrIleAspAspAlaGluLeuThrValGlnArgArgLysThrThr-281 287-LeuSerHisLysGlyTyrIleGlyArgSerThrAlaAspPheLysLeuLysTyrLysHisGlyThrGlyMet LysAspAlaLeuArgAlaProGluGluAlaPheGlyGluGlyThrSerArg-327 334-SerAlaAspValAsnThrPro-340 357-GlnTrpAsnLysThrProLeuThrSerGlnAspLysLeuAla-370 375-HisThrValArgGlyPheAspGlyGluMetSerLeuProAlaGluArgGlyTrpTyrTrpArgAsnAspLeu SerTrpGlnPheLysProGlyHis-406 418-SerGlyGlnSerAlaLys-423 455-ArgAlaLeuLysLysProGluTyrPheGlnThrLysLysTrpValThr-470 Hydrophilic Regions - Hopp-Woods 35-GlnAspLeuAsnSerGlyLys-41 54-11eArgl1eAspArgSerAsnAspAspGlnThrHisAla-66 76-PheProThrArgSerAsnAsp-82 87-ArgAεpLeuGluGlnGlyLeuGluAεn-95 102-AlaGluAlaAspLeu-106 110-ProValGluArgGluProAsnGlnSer-118 137-MetAspAsnSerGlySerGluAlaThrGlyLysTyr-148 174-IleGlyGlyThrProAspGluGluAsnPheAspGlyHisArgLysGluGlyGlySer-192 228-TyrAspTyrAsnGly-232 245-LeuTyrArgAspAlaLysArgLysThrTyrLeu-255 260-TrpThrArgGluThrLysSerTyrIleAspAspAlaGluLeuThrValGlnArgArgLysThrThr-281 296-SerThrAlaAspPheLysLeuLysTyrLysHis-306 308-ThrGlyMetLysAspAlaLeuArgAlaProGluGluAlaPheGly-322 362-ProLeuThrSerGlnAspLysLeuAla-370 378-ArgGlyPheAspGlyGluMet-384 455-ArgAlaLeuLysLysProGluTyrPheGln-464 g931 AMPHI Regions - AMPHI 43-LysAlaSerLysThrValAlaAsnPheValArgTyrAlaArgLys-57 67-ArgValIleGlyGly-71 81-GluAspLeuValGlnLysAlaThrAspLysAla-91 93-AlaAsnGluSerGlyAsnGlyLeuLysAsnThrValGly-105 142-ThrValPheGlyArgValGluSerGlyMetAspThrValSerLysIleAlaArgValLysThrAlaThrArg GlyPhe-167 Antigenic Index - Jameson-Wolf l-MetLysProLysPhe-5 30-ThrAspMetGlyAsn-34 38-ValLeuAspGluSerLysAlaSerLysThr-47 54-TyrAlaArgLysGlyPheTyrAspAsn-62 75-GlnGlyAspGlyLeuThrGluAspLeuValGlnLysAlaThrAspLysAlaValAlaAsnGluSerGlyAsnG lyLeuLysAsnThrVa1-104 113-AlaAlaProAspSerAla-118 127-AlaAspAsnGlySerLeuAspTyrLysAεnGlyGlnTyrGly-140 145-GlyArgValGluSerGlyMetAspThrValSerLysIleAlaArgValLysThrAlaThrArgGlyPhe-16 7 176-ValLysIleArgArg-180 Hydrophilic Regions - Hopp-Woods l-MetLysProLysPhe-5 30-ThrAspMetGlyAsn-34 38-ValLeuAspGluSerLysAlaSerLysThr-47 78-GlyLeuThrGluAspLeuValGlnLyεAlaThrAspLysAlaValAlaAsnGluSerGlyAεnGlyLeu-lOO 113-AlaAlaProAεpSerAla-118 13 O-GlySerLeuAspTyrLysAsn-136 145-GlyArgValGluSerGlyMetAspThrValSerLysIleAlaArgValLysThrAlaThr-164 176-ValLysIleArgArg-180 g933 AMPHI Regions - AMPHI 26-ProAεnIleProAlaLeuPheProLysHisProPheAspProPheGluAsnIleAsnAsnSerLysLys-48 63-GlyPheAlaArgGly-67 78-GluLysProLeuArgGlnTyrPheLysAεpCysValAsnThr-91 lOl-IleSerSerPheGlyAsn-106 135-ValGlyAsnTyrIleGluTrpLeu-142 145-ThrLeuAsnLysLeuThrGlyTrpGlnGluHisLeuTyrAlaGlyLeuAspProPheHisTyrIleGluVal -168 264-AlaLeuAspAsnLeuLysHisLeuAspGlyHisGlnIleValLysValAsn-280 309-GlyPhePheThrLys-313 356-TrpLeuArgValIleAspGlyHisSerAεn-365 374-ProValGluGlyTyrArgLysGly-381 431-AlaGlyValTyrAlaThrTrpHis-438 447-AlaTyrValAspSerTrpMetGlnTyrGln-456 474-LysGlyIleThrAlaSer-479 483-GlyTyrAsnAlaLeuLeuAla-489 555-GlnProPheValAlaVal-560 606-PheAsnArgGlnThrSer-611 Antigenic Index - Jameson-Wolf 1-LysLysLeuArgAspArgAsnSerGluTyrTrpLysGluGluThrTyrHisIleLysSerAsnGlyArgThrTy rPro-26 33-ProLysHisProPheAspProPheGluAsnIleAsnAsnSerLysLysIleSerPheTyrAspLysGluTyrT hrGluAspTyr-60 68-PheGlyValGluLysArgAsnGlyGluGluGluLysProLeuArg-82 88-CysValAsnThrGluAsnSerAsnAsnAspAsnCysLysIleSerSer-103 112-IleLysSerAspIle-116 122-GlnIleLysAsnSerHisIleAsnSerGluIle-132 144-ProThrLeuAsnLysLeuThrGlyTrpGlnGlu-154 167-GluValThrAspAsnSerHis-173 189-SerLeuTrpLysProArgTrpAsnSerAsnlle-199 205-LysAsnAlaGluIleArgPheAsnThrLysAsnGluSerLeuLeuValLysGluAεpTyrAlaGlyGlyAla ArgPhe-230 234-TyrAspLeuLysAεpLysValProGlu-242 248-PheGluLysAsnIleThrGlyThrSer-256 263-LysAlaLeuAspAsnLeuLysHiεLeuAspGlyHisGlnIleValLysValAsnAspThrAlaAspLysAsp AlaPheArgLeuSerSerLysTyrArgLys-296 303-LeuGlnGlnArgProGluGlyPhe-310 313-LysValGlnGluArgAspAspIle-320 337-ArgLeuAsnAspLysAsnSerAspIlePheAspArgThrLeuProArgLysGlyLeu-355 360-IleAspGlyHisSerAsnGlnTrpValGlnGlyLysThrAlaProValGluGlyTyrArgLysGlyVal-38 2 392-GlnAsnGluSerAsnGlnLeu-398 403-MetGlyGlyGlnAlaGluGlnArgSerThrPheArgAsnProAspThrAspAsnLeuThr-422 424-GlyAsnValLysGly-428 440-LeuGlnAspLysGlnThrGlyAlaTyr-448 456-GlnArgPheArgHisArgIleAsnThrGluTyrAlaThrGluArgPheThrSerLysGlyIle-476 491-HisPheThrLysLysGlyAsnSerLeu-499 514-ValAsnGlyLysPheSerAspSerGluAsnAla-524 529-LeuGlySerArgGlnLeuGlnSerArgValGlyVal-540 567-LysProPheGlyValGluIleAspGlyAspArgArgValIleAsnAsnLysThrValIleGluThr-588 594-AlaLysIleLysSer-598 605-SerPheAsnArgGlnThrSerLysHisHisHisAlaLys-617 Hydrophilic Regions - Hopp-Woods l-LysLysLeuArgAspArgAsnSerGluTyrTrpLysGluGluThrTyrHis-17 20-SerAsnGlyArgThr-24 35-HisProPheAspPro-39 44-AsnAsnSerLysLysIleSerPheTyrAspLysGluTyrThrGlu-58 68-PheGlyValGluLysArgAsnGlyGluGluGluLysProLeu-81 88-CysValAεnThrGluAsnSerAsnAsnAspAsnCysLys-lOO 205-LysAsnAlaGluIleArgPheAsnThrLysAsnGluSerLeuLeuValLysGluAspTyrAlaGly-226 234-TyrAspLeuLysAspLysValProGlu-242 250-LysAεnIleThrGly-254 263-LysAlaLeuAspAsnLeuLysHisLeuAsp-272 278-LysValAsnAspThrAlaAspLysAspAlaPheArgLeuSerSerLysTyrArgLys-296 304-GlnGlnArgProGluGlyPhe-310 314-ValGlnGluArgAspAspIle-320 338-LeuAsnAspLysAsnSerAεpIlePheAsp-347 376-GluGlyTyrArgLysGlyVal-382 393-AsnGluSerAsnGln-397 406-GlnAlaGluGlnArgSerThrPheArgAsnProAspThrAspAsnLeuThr-422 440-LeuGlnAspLysGlnThr-445 456-GlnArgPheArgHisArgIleAsnThr-464 491-HisPheThrLysLysGlyAsnSer-498 517-LysPheSerAspSerGluAsnAla-524 532-ArgGlnLeuGlnSer-536 569-PheGlyValGluIleAspGlyAspArgArgValIleAsn-581 594-AlaLysIleLysSer-598 606-PheAsnArgGlnThrSerLysHisHisHisAlaLys-617 g933 AMPHI Regions - AMPHI 26-ProAsnIleProAlaLeuPheProLysHisProPheAspProPheGluAsnIleAsnAsnSerLysLys-48 63-GlyPheAlaArgGly-67 78-GluLysProLeuArgGlnTyrPheLysAspCysValAsnThr-91 lOl-IleSerSerPheGlyAsn-106 135-ValGlyAsnTyrIleGluTrpLeu-142 145-ThrLeuAsnLysLeuThrGlyTrpGlnGluHisLeuTyrAlaGlyLeuAspProPheHisTyrIleGluVal -168 264-AlaLeuAspAsnLeuLysHisLeuAspGlyHisGlnIleValLysValAsn-280 309-GlyPhePheThrLys-313 356-TrpLeuArgValIleAspGlyHisSerAsn-365 374-ProValGluGlyTyrArgLysGly-381 43l-AlaGlyValTyrAlaThrTrpHis-438 447-AlaTyrValAspSerTrpMetGlnTyrGln-456 474-LysGlyIleThrAlaSer-479 483-GlyTyrAsnAlaLeuLeuAla-489 555-GlnProPheValAlaVal-560 606-PheAsnArgGlnThrSer-611 Antigenic Index - Jameson-Wolf 1-LysLysLeuArgAspArgAsnSerGluTyrTrpLysGluGluThrTyrHisIleLysSerAsnGlyArgThrTy rPro-26 33-ProLysHisProPheAspProPheGluAsnIleAsnAsnSerLysLysIleSerPheTyrAspLysGluTyrT hrGluAspTyr-60 68-PheGlyValGluLysArgAsnGlyGluGluGluLysProLeuArg-82 88-CysValAsnThrGluAsnSerAsnAsnAspAsnCysLysIleSerSer-103 112-IleLysSerAspIle-116 122-GlnIleLysAsnΞerHisIleAsnSerGluIle-132 144-ProThrLeuAsnLysLeuThrGlyTrpGlnGlu-154 167-GluValThrAspAsnSerHis-173 189-SerLeuTrpLysProArgTrpAsnSerAsnIle-199 205-LysAsnAlaGluIleArgPheAsnThrLysAsnGluSerLeuLeuValLysGluAspTyrAlaGlyGlyAla ArgPhe-230 234-TyrAspLeuLysAspLysValProGlu-242 248-PheGluLysAsnIleThrGlyThrSer-256 263-LysAlaLeuAspAsnLeuLysHisLeuAspGlyHisGlnIleValLysValAsnAspThrAlaAspLysAsp AlaPheArgLeuSerSerLysTyrArgLys-296 303-LeuGlnGlnArgProGluGlyPhe-310 313-LysValGlnGluArgAspAspIle-320 337-ArgLeuAsnAspLysAsnSerAspIlePheAspArgThrLeuProArgLysGlyLeu-355 360-IleAspGlyHisSerAsnGlnTrpValGlnGlyLysThrAlaProValGluGlyTyrArgLysGlyVal-38 2 392-GlnAsnGluSerAsnGlnLeu-398 403-MetGlyGlyGlnAlaGluGlnArgSerThrPheArgAsnProAspThrAspAsnLeuThr-422 424-GlyAsnValLysGly-428 440-LeuGlnAspLysGlnThrGlyAlaTyr-448 456-GlnArgPheArgHisArgIleAsnThrGluTyrAlaThrGluArgPheThrSerLysGlyIle-476 491-HisPheThrLysLysGlyAsnSerLeu-499 514-ValAsnGlyLysPheSerAspSerGluAsnAla-524 529-LeuGlySerArgGlnLeuGlnSerArgValGlyVal-540 567-LysProPheGlyValGluIleAspGlyAspArgArgValIleAsnAsnLysThrValIleGluThr-588 594-AlaLysIleLysSer-598 605-SerPheAsnArgGlnThrSerLysHisHisHisAlaLys-617 Hydrophilic Regions - Hopp-Woods l-LysLysLeuArgAspArgAsnSerGluTyrTrpLysGluGluThrTyrHis-17 20-SerAsnGlyArgThr-24 35-HisProPheAspPro-39 44-AεnAsnSerLysLyεIleSerPheTyrAspLysGluTyrThrGlu-58 68-PheGlyValGluLysArgAsnGlyGluGluGluLysProLeu-81 88-CysValAsnThrGluAsnSerAsnAsnAspAsnCysLys-100 205-LysAsnAlaGluIleArgPheAsnThrLysAsnGluSerLeuLeuValLysGluAspTyrAlaGly-226 234-TyrAspLeuLysAspLysValProGlu-242 250-LysAsnIleThrGly-254 263-LysAlaLeuAspAsnLeuLysHisLeuAsp-272 278-LysValAsnAspThrAlaAspLysAspAlaPheArgLeuSerSerLysTyrArgLys-296 304-GlnGlnArgProGluGlyPhe-310 314-ValGlnGluArgAspAspIle-320 338-LeuAsnAspLysAsnSerAspIlePheAsp-347 376-GluGlyTyrArgLysGlyVal-382 393-AsnGluSerAsnGln-397 406-GlnAlaGluGlnArgSerThrPheArgAsnProAspThrAspAsnLeuThr-422 440-LeuGlnAspLysGlnThr-445 456-GlnArgPheArgHisArgIleAsnThr-464 491-HisPheThrLysLysGlyAsnSer-498 517-LysPheSerAspSerGluAsnAla-524 532-ArgGlnLeuGlnSer-536 569-PheGlyValGluIleAspGlyAspArgArgValIleAsn-581 594-AlaLysIleLysSer-598 606-PheAsnArgGlnThrSerLysHisHisHisAlaLys-617 g936-l AMPHI Regions - AMPHI 10-ThrLeuIleAlaAla-14 19-AlaLeuGlyGlyCysPheSerAlaVal-27 100-GlnPheValGlyGlnIle-105 112-AlaGluGlyValTyrAsnTyrIleThrValAlaSerLeuProArgThrAlaGlyAspIleAlaGlyAsp-13 4 Antigenic Index - Jameson-Wolf l-MetLysProLysProHisThrVal-8 37-SerValIleAspArgArgThrThrGlyAlaGlnThrAspAspAsnValMet-53 56-ArgIleGluThrThrAlaArgSerTyrLeuArgGlnAsnAsnGlnThrLysGlyTyr-74 94-AlaThrGluGlyGluLysGlnPhe-101 106-AlaArgSerGluGlnAlaAla-112 124-LeuProArgThrAlaGlyAspIleAlaGlyAspThrTrpAsnThrSerLysValArgAla-143 149-SerProAlaThrGlnAlaArgValLys-157 172-ThrProGluGluGlnAlaGlnIleThr-180 Hydrophilic Regions - Hopp-Woods l-MetLysProLysProHisThr-7 37-SerValIleAspArgArgThrThrGlyAlaGlnThrAspAspAsnValMet-53 56-ArgIleGluThrThrAla-61 68-AsnAsnGlnThrLysGlyTyr-74 94-AlaThrGluGlyGluLysGlnPhe-101 106-AlaArgSerGluGlnAlaAla-112 125-ProArgThrAlaGly-129 152-ThrGlnAlaArgValLys-157 172-ThrProGluGluGlnAlaGlnIle-179 g937 AMPHI Regions - AMPHI 121-LysArgMetSerAspIleSerAlaGlyIleSerHis-132 231-LysGlnProAspArgIleAsp-237 Antigenic Index - Jameεon-Wolf 18-ThrAεpLeuProLeuAsnIle-24 26-AspIleMetThrAspLysGlyLysTrpLysLeuGluThr-38 43-LeuAsnSerGluAsnSerArgAlaAlaLeu-52 69-ProThrGluIleGlnGluAsnGlySerAsnThrAεp-80 94-GlyAsnThrAspIleTyrGlySerGlySer-103 107-HisGluGluArgLysLeuAspGlyAsnGlyLysThrArgAsnLysArgMetSerAspIle-126 134-PheLeuLysAspGlyLysAsnProAla-142 150-ThrValTyrGluLysSerArgAsnLysAlaSerSerGlyLys-163 186-TyrArgIleAsnGlySerLysThrLeuSerAspAspValLysTyrLysAlaGly-203 216-AlaAsnAspArgIleSerLeuThrGlyGly-225 230-GlyLysGlnProAspArgIleAspGlyLysLyεGluSerAlaArgAsnThrSerThr-248 272-ValSerGlyGlnSerSerSerGluLeuLyεLeu-282 Hydrophilic Regions - Hopp-Woods 26-AspIleMetThrAspLysGlyLysTrpLysLeu-36 46-GluAsnSerArgAlaAlaLeu-52 71-GluIleGlnGluAεnGlySerAsnThr-79 107-HisGluGluArgLysLeuAspGlyAsnGlyLysThrArgAsnLysArgMetSerAspIle-126 134-PheLeuLysAspGlyLysAsn-140 150-ThrValTyrGluLysSerArgAsnLysAlaSerSerGly-162 192-LysThrLeuSerAspAspValLysTyrLysAla-202 216-AlaAsnAspArgIleSer-221 231-LysGlnProAspArgIleAspGlyLysLysGluSerAlaArgAsn-245 276-SerSerSerGluLeuLysLeu-282 g950 AMPHI Regions - AMPHI 33-GlyValGlnLysSerAlaGlnGly-40 81-AlaThrValLysLysAlaHisLysHisThrLysAla-92 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnIle-5 26-LysProAlaSerAsnAlaThrGlyValGlnLysSerAlaGlnGlySerCysGlyAlaSerLysSerAlaGluG lySerCysGlyAlaSerLysSerAlaGluGlySerCysGly-63 65-AlaAlaSerLysAlaGlyGluGlyLysCysGlyGluGlyLysCysGlyAlaThrValLysLysAlaHisLysH isThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysGlyGluGlyLysCysGlySerLys-112 Hydrophilic Regions - Hopp-Woods 33 -GlyValGlnLysSerAlaGln-39 43-GlyAlaSerLysSerAlaGluGlySerCysGlyAlaSerLysSerAlaGluGlySerCys-62 65-AlaAlaSerLysAlaGlyGluGlyLysCysGlyGluGlyLysCys-79 81-AlaThrValLysLysAlaHisLysHisThrLysAlaSerLysAlaLysAlaLysSerAlaGluGlyLysCysG lyGluGlyLysCysGlySerLys-112 g951 AMPHI Regions - AMPHI 9-ThrIleLeuSerValLeuAlaAla-16 32-GluLeuProLysGluValGlyLysValLeuArgLysHisArgArgTyr-47 62-ValGlyGluArgValAsnArgValPhe-70 127-TrpArgGlnIleGluProIleProGlyGlu-136 145-ArgAsnValLeuArgGluGlyGlyAsnGlnHisLeuAspGlyLeuGluGluValLeuAla-164 189-AlaGlnLysAlaSerLysAlaValArgArg-198 204-GluHisLeuProGluAlaAla-210 227-IleGluAlaLeuGlnArgLeuAlaLysLeu-236 254-LysTyrProGluIleLeuAspGlyPhePheGlu-264 278-MetGluIleMetAsnLeuValSerLeuArgLysProAspAspAla-292 325-ValIleAspGlyTyrAlaGluLys-332 362-ValArgGlnTrpLeuLys-367 395-AlaLeuArgGlnIleGlyArgValArgLysLeuProGluGlnGln-409 416-AspAsnLeuSerLysIle-421 423-MetLeuAlaLeuSer-427 441-AsnIleIleAlaLysLeuSerAlaAlaGlySerThrGluProLeuAlaGlu-457 474-LysMetIleAlaAspLeuGluThr-481 495-AsnLeuGlyTyrSer-499 503-AspSerLysArgLeu-507 563-HisLeuGlyGluVal-567 579-AspValTrpThrGlnAla-584 592-LysIleTrpArgGluThrLeuLys-599 Antigenic Index - Jameson-Wolf 29-AlaAspValGluLeuProLysGluValGlyLysValLeuArgLysHisArgArgTyrSerGluGluGluIleL ysAsnGluArgAlaArgLeu-59 61-AlaValGlyGluArgValAsnArg-68 77-ThrAlaLeuGlnLysGlyGlnAla-84 96-GluArgThrLysSerProGluValAlaGluArgAlaLeuGlu-109 126-LysTrpArgGlnIleGluProIleProGlyGluAlaGlnLysArgAlaGlyTrp-143 147-ValLeuArgGluGlyGlyAsnGlnHisLeuAspGlyLeuGluGluValLeuAlaGlnSerAspAspValGln LysArgArgIle-174 187-GlyValAlaGlnLysAlaSerLysAlaValArgArgAlaAlaLeuLys-202 219-GlnGlyArgGluLysGluLysAlaIleGluAlaLeuGlnArgLeuAlaLysLeuAspThrGluIleLeuPro -242 250-LeuThrAlaArgLysTyrProGluIleLeuAspGlyPhePheGluGlnThrAspThrGlnAsn-270 285-SerLeuArgLysProAspAspAlaTyrAla-294 301-GluHisAsnProAsnAlaAsn-307 317-AlaAsnArgLysGluGlyAlaSer-324 326-IleAspGlyTyrAlaGluLysAlaTyrGlyArgGlyThrGlyGluGlnArgGlyArgAla-345 354- laAspArgArgAspTyrAlaLys-361 364-GlnTrpLeuLysLysValSerAlaPro-372 375-LeuPheAspLysGlyVal-380 387-AlaGluLeuAspGlyGlyArgAlaAlaLeu-396 398-GlnlleGlyArgValArgLysLeuProGluGlnGlnGlyArgTyrPheThr-414 428-LysLeuProAspLysArgGluAlaLeu-436 447-SerAlaAlaGlySerThrGluProLeuAla-456 467-GluGlnPheGlyLysArgGlyLysMetIleAlaAspLeuGluThr-481 485-LeuThrProAspAsn-489 501-LeuSerAspSerLysArgLeuAspGluGlyPhe-511 519-GlnIleAsnProAεpAεpThrAlaValAsnAspSerIle-531 537-LeuLysGlyAspAlaGluSerAla-544 549-ArgTyrSerPheGluAsnAspProGluProGluVal-560 572-GlyGluArgAspGlnAla-577 585-AlaHisLeuArgGlyAspLysLysIleTrpArgGluThrLeuLysArgTyrGly-602 604-AlaLeuProGluProSerArgLysProArgLys-614 Hydrophilic Regions - Hopp-Woods 29-AlaAspValGluLeuProLysGluValGlyLysValLeuArgLysHisArgArgTyrSerGluGluGluIleL ysAsnGluArgAlaArgLeu-59 61-AlaValGlyGluArgValAsnArg-68 77-ThrAlaLeuGlnLysGlyGlnAla-84 96-GluArgThrLysSerProGluValAlaGluArgAlaLeuGlu-109 133-IleProGlyGluAlaGlnLysArgAlaGlyTrp-143 147-ValLeuArgGluGlyGlyAsnGlnHis-155 157-AspGlyLeuGluGluValLeuAlaGlnSerAspAspValGlnLysArgArgIle-174 188-ValAlaGlnLysAlaSerLysAlaValArgArgAlaAlaLeuLys-202 219-GlnGlyArgGluLysGluLysAlaIleGluAlaLeuGlnArgLeuAlaLysLeuAspThrGluIle-240 250-LeuThrAlaArgLysTyrProGluIle-258 263-PheGluGlnThrAspThrGlnAsn-270 285-SerLeuArgLysProAspAspAlaTyrAla-294 317-AlaAsnArgLysGluGlyAlaSer-324 329-TyrAlaGluLysAlaTyrGly-335 337-GlyThrGlyGluGlnArgGlyArgAla-345 354-AlaAspArgArgAspTyrAlaLys-361 387-AlaGluLeuAspGlyGlyArgAlaAlaLeu-396 398-GlnIleGlyArgValArgLysLeuProGluGlnGlnGly-410 428-LysLeuProAspLysArgGluAlaLeu-436 450-GlySerThrGluProLeuAla-456 469-PheGlyLysArgGlyLysMetIleAlaAspLeuGluThr-481 485-LeuThrProAspAsn-489 502-SerAspSerLysArgLeuAspGlu-509 521-AsnProAspAspThrAlaVal-527 539-GlyAspAlaGluSer-543 552-PheGluAsnAspProGluProGluVal-560 572-GlyGluArgAspGlnAla-577 587-LeuArgGlyAspLysLys11eTrpArgGluThrLeuLys-599 607-GluProSerArgLysProArgLys-614 g952 AMPHI Regions - AMPHI 47-SerValAlaThrLeuLeuAsn-53 66-LeuGluLysLeuGlyLysGluGlnMetArgAla-76 78-PheGluAspMetArgArgl1e-84 100-GluGlnLeuAlaGlnLeu-105 122-SerValLeuArgGlyVal-127 147-AlaGlnPheLeuGluAla-152 Antigenic Index - Jameson-Wolf 2 -GlnSerTrpLysAlaArgArgAεpPheAsnIleValLysGlnAspLeuAspPheSerCys-43 59-LysLeuThrGluGluGluValLeuGluLysLeuGlyLysGluGlnMetArgAlaSerPheGluAspMetArgA rgIleMetPro-86 88-LeuGlyPheGluAlaLysGlyTyr-95 113-LeuLysTyrArgLysAspAspHisPheSer-122 125-ArgGlyValAspGlyAsnThr-131 135-AlaAspProSerProGlyHis-141 153-TrpGlnThrArgGluGlyAsnLeuAlaGly-162 168-ValProLysLysAlaGluAlaIleSer-176 183-HisHisProLysArgGlnThrGlu-190 Hydrophilic Regions - Hopp-Woods 25-SerTrpLysAlaArgArgAspPheAsnIleValLysGlnAspLeuAspPhe-41 59-LyεLeuThrGluGluGluValLeuGluLysLeuGlyLysGluGlnMetArgAlaSerPheGluAspMetArgA rgIleMetPro-86 88-LeuGlyPheGluAlaLysGly-94 114-LysTyrArgLysAspAspHisPheSer-122 153-TrpGlnThrArgGluGlyAsnLeu-160 168-ValProLysLysAlaGluAlaIleSer-176 184-HisProLysArgGlnThrGlu-190 g953 AMPHI Regions - AMPHI 38-AsnThrSerThrAsnValGlyGlyPheTyrGlyLeuThr-50 79-ProPheThrGlyHis-83 85-LysSerAlaAspIlePheAspAlaAlaGln-94 150-GlyAspPheSerThrThr-155 Antigenic Index - Jameson-Wolf 21-TyrLysValAspGluTyrHisAla-28 37-PheAsnThrSerThrAsnVal-43 53-ValGluPheAspGlnAlaLysArgAspGlyLysIleAspIle-66 74-GlnSerGlySerGlnPro-79 94-GlnTyrProAspIleArgPheValSer-102 104-LysPheAsnPheAsnGlyLysLysLeuValSer-114 121-MetArgGlyLysThrAlaProValLysLeuLysAlaGluLys-134 136-AsnCysTyrGlnSerProMetAlaGluThrGluValCysGlyGlyAspPheSerThrThrIleAspArgThr LysTrpGlyValAsp-164 170-GlyMetThrLysAεnValArgIle-177 179-IleGlnIleGluAlaAlaLysGln-186 Hydrophilic Regions - Hopp-Woods 21-TyrLysValAspGluTyrHisAla-28 53-ValGluPheAspGlnAlaLysArgAspGlyLysIleAspIle-66 107-PheAsnGlyLysLysLeuValSer-114 121-MetArgGlyLysThrAlaProValLyεLeuLysAlaGluLys-134 142-MetAlaGluThrGluValCysGly-149 154-ThrThrIleAspArgThrLysTrp-161 173-LysAsnValArgIle-177 179-IleGlnIleGluAlaAlaLysGln-186 g957-2 AMPHI Regions - AMPHI H-SerPhePheAlaLeuValPheAla-18 39-AlaThrGluValProGluAsnPro-46 48-AlaPheValAlaLysLeuAlaArgLeuPheArgAsnAla-60 74-GluGluSerLeuAlaGlyAlaValAspAsp-83 167-HisGlyGluAsnTyrGluThr-173 198-GluAspValTyrGluHisCysLeuGlyCysTyrGlnMet-210 218-TyrArgAspValAlaAsn-223 235-SerAsnArgIleAlaSer-240 251-MetArgGluLeuMetProArg-257 355-GluLysGluValSerArgTyrAlaGluAlaAlaAlaArg-367 Antigenic Index - Jameson-Wolf 29-IleAsnProArgTrp-33 35-LeuSerAspThrAlaThrGluValProGluAεnProAsnAla-48 57-PheArgAsnAlaAspArgAla-63 67-ValLysGluSerMetArgThrGluGluSerLeu-77 80-AlaValAspAspGlyProLeuGlnSerGluLysAspTyr-92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyGlu-118 125-TyrIleGlyGluGlyGly-130 136-LeuSerGlnArgSerProGluAlaPheVal-145 149-TyrLeuTyrArgAsnAspArgProPheSer-158 166-AlaHisGlyGluAsnTyrGluThrThrGlyGluTyrArgVal-179 182-GlnProAspGlySerVal-187 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LyεTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgGluGluSerAsnArgIleAlaSer AspSerArgAspTyrVal-246 250-AsnMetArgGluLeuMetProArgGlyMetLysAlaAsnSer-263 267-GlyTyrAspAlaAspGlyLeuProGlnLys-276 280-SerPheAspAsnGlyLysLysArgGlnSerPheGluTyrTyrLeuLysAsnGlyAsn-298 309-LeuLyεAlaAspGlyValThr-315 329-LeuAspGlyGlyArgIleIleArgGluGluLysGlnGlyAspArgLeuProAspPhe-347 349-LeuAsnLeuGluAspLeuGluLysGluValSerArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArg ArgGlyLeuSerHis-377 Hydrophilic Regions - Hopp-Woods 38-ThrAlaThrGluValProGluAsnPro-46 57-PheArgAsnAlaAspArgAla-63 67-ValLysGluSerMetArgThrGluGluSerLeu-77 80-AlaValAspAspGlyProLeuGlnSerGluLysAspTyr-92 98-ArgLeuSerArgLeuLysGluLysAlaLys-107 112-ThrGluGlnGluHisGlyGlu-118 136-LeuSerGlnArgSerProGlu-142 151-TyrArgAsnAspArgProPhe-157 169-GluAsnTyrGluThrThrGlyGluTyr-177 190-AlaAlaGlyArgGlyLysIleGlyGluAspValTyr-201 217-LysTyrArgAspValAlaAsnAspGluGlnLysValTrpAspPheArgGluGluSerAsnArgIleAlaSer AspΞerArgAsp-244 250-AsnMetArgGluLeuMetProArgGlyMetLys-260 268-TyrAspAlaAspGlyLeuPro-274 282-AspAsnGlyLysLysArgGlnSer-289 309-LeuLysAlaAspGlyValThr-315 331-GlyGlyArgIleIleArgGluGluLysGlnGlyAspArgLeuPro-345 349-LeuAsnLeuGluAspLeuGluLysGluValSerArgTyrAlaGluAlaAlaAlaArgArgSerGlyGlyArg ArgGlyLeuSer-376 g958 AMPHI Regions - AMPHI 39-GlyGlyAlaGlnGlyAlaSerGluSerAlaGln-49 85-ProGluAspTyrThrArgIleValAlaAsp-94 175-GlyArgArgLeuGlnSerValSerArgThrAlaGluMetLeuGly-189 342-IleSerAspThrLeuGln-347 400-GlnLysTyrGlnThrLeuAlaAsn-407 426-TrpHisLysAsnAlaGly-431 489-GlyGlyLysAlaSerArgSerValGlyArgValLeuProValVal-503 526-IleGluProArgLeu-530 540-GlnAsnAspLeuProAsnPheAsp-547 571-AsnAlaAlaAsnSerLeuSerThrAlaValGlnSer-582 615-ValGlyLysAsnPro-619 692-AspLysLeuSerGln-696 722-LysLysProIleGlu-726 768-AspLeuSerSerValGlyArgAsnPro-776 Antigenic Index - Jameson-Wolf 19-GlyThrHisCysAla-23 27-ValAlaAlaGluGluAlaAspGlyArgValAlaGluGlyGlyAlaGlnGlyAlaSerGluSerAlaGlnAlaS er-51 62-CysSerAsnGluSerGlySerProGluArgThrGluAlaAlaValGlnGlySerGlyGluAlaSerValProG luAspTyrThrArgIleValAlaAspArgMetGluGlyGlnSerLysValLysValArgAlaGluGly-108 110-ValIleIleGluArgAspGlyAlaValLeu-119 122-AspTrpAlaAspTyrAspGlnSerGlyAsp-131 134-ThrValGlyAspArgPheAlaLeuGlnGlnAspGlyThrLeuIleArgGlyGluThrLeu-153 157-LeuAspGlnGlnThrGlyGluAlaHisAsnValArgMetGluThrGluGlnGlyGlyArgArgLeuGlnSer ValSerArgThrAlaGluMetLeuGlyGluGlyArgTyrLysLeuThrGluThrGlnPheAsnThrCysSerAlaG lyAspAlaGlyTrp-210 215-AlaSerValGluAlaAspArgGlyLysGlyIleGly-226 248-PheProLeuAspGlyAsnArgLysSerGlyLeu-258 264-SerAlaGlySerAspGlyVal-270 291-GlyIleIleGlyGluArgGlyAlaThrPheAspGlyGlnIleArgTyrLeuArgProAspTyrSerGlyGln ThrAsp-316 320-LeuProHisAspLysLysSerGlyArgAsnAsnArgTyrGlnAla-334 336-TrpGlnHisArgHisAspIleSerAspThrLeu-346 351-AspPheAsnGlnValSerAspSerGlyTyrTyrArgAspPheTyrGlyGlyGluGluIleAlaGlyAsnVal AsnLeuAsnArgArgValTrp-381 383-AspTyrGlyGlyArgAlaAlaGlyGlySerLeuAsn-394 400-GlnLysTyrGlnThr-404 406-AlaAsnGlnSerGlyTyrLysAspGluProTyr-416 420-ProArgLeuSerAlaAspTrpHisLysAsnAlaGlyArgAlaGlnIle-435 443 -ArgPheSerHisAspGlyArgGlnAspGlySerArg-454 465-PheSerAsnSerTrpGly-470 473-ArgProLysLeuGlyLeu-478 487-SerPheGlyGlyLysAlaSerArgSerValGlyArg-498 506-AspGlyGlyThrThrPheGluArgAsnThrArgLeuPheGlyGlyGly-521 537-AlaLysSerGlnAsnAspLeuProAsnPheAspSerSerGluSerSerPheGly-554 559-PheArgGluAsnLeuTyrTyrGlyAsnAspArglleAsnAla-572 583-ArgIleLeuAspGlyAlaThrGlyGluGluArgPheArgAlaGlyIleGlyGlnLysPheTyrPheLysAsp AspAlaValMetLeuAspGlySerValGlyLysAsnProArgSerArgSerAspTrp-625 630-SerGlyGlyIleGlyGly-635 641-SerSerIleHisTyrAsnGlnAsnAspLysArgAlaGluHis-654 659-AlaGlyTyrArgProAlaProGlyLysValLeuAsnAlaArgTyrLysTyrGlyArgAsnGluLysIle-68 1 692-AspLysLeuSerGln-696 717-TyrGlyPheGluAlaLysLysProIleGlu-726 731-AlaGluTyrLysSerSerCysGlyCysTrp-740 750-ValThrGlyGluAsnThrTyrLysAsn-758 765-GlnLeuLysAspLeuSerSerValGlyArgAsnProAlaGlyArgMetAspVal-782 792-SerLeuSerAlaGlyArgAsnLysArgPro-801 Hydrophilic Regions - Hopp-Woods 27-ValAlaAlaGluGluAlaAspGlyArgValAlaGluGlyGlyAla-41 43-GlyAlaSerGluSerAlaGlnAlaSer-51 64-AsnGluSerGlySerProGluArgThrGluAlaAlaVal-76 78-GlySerGlyGluAlaSerValProGluAspTyrThr-89 92-ValAlaAspArgMetGluGlyGlnSerLysValLysValArgAlaGluGly-108 110-ValIleIleGluArgAspGlyAla-117 124-AlaAspTyrAspGlnSerGlyAsp-131 146-ThrLeuIleArgGlyGluThr-152 159-GlnGlnThrGlyGluAlaHisAsnValArgMetGluThrGluGlnGlyGlyArgArgLeuGlnSerValSer ArgThrAlaGluMetLeuGlyGluGlyArgTyrLysLeuThrGlu-197 215-AlaSerValGluAlaAspArgGlyLysGly-224 249-ProLeuAspGlyAsnArgLysSerGly-257 265-AlaGlySerAspGlyVal-270 293-IleGlyGluArgGlyAlaThr-299 304-IleArgTyrLeuArg-308 322-HisAspLysLysSerGlyArgAsnAsnArgTyrGlnAla-334 336-TrpGlnHisArgHisAspIleSerAsp-344 409-SerGlyTyrLysAspGluProTyr-416 422-LeuSerAlaAspTrpHisLysAsnAlaGlyArgAla-433 444-PheSerHisAspGlyArgGlnAspGlySerArg-454 488-PheGlyGlyLysAlaSerArgSerValGly-497 509-ThrThrPheGluArgAsnThrArg-516 538-LysSerGlnAsnAsp-542 547-AspSerSerGluSer-551 568-AspArgIleAsnAla-572 588-AlaThrGlyGluGluArgPheArgAla-596 603-TyrPheLysAspAspAlaValMet-610 614-SerValGlyLysAsnProArgSerArgSerAsp-624 647-GlnAsnAspLysArgAlaGluHis-654 673-TyrLysTyrGlyArgAsnGluLysIle-681 719-PheGluAlaLysLysProIleGlu-726 731-AlaGluTyrLysSer-735 765-GlnLeuLysAspLeuSerSerValGlyArgAsnProAlaGlyArgMetAspVal-782 794-SerAlaGlyArgAsnLysArgPro-801 g959 AMPHI Regions - AMPHI 56-AlaAlaTrpAlaArgValGlyGly-63 Antigenic Index - Jameson-Wolf 24-AlaHisHisAspGlyHisGlyAspAspAspHisGlyHis-36 38-AlaHisGlnHisGlyLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAla-57 60-ArgValGlyGlyLysIleThrAspIleAspLeuGluHisAspAspGlyArgProHisTyrAspValGluIleV alLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArgVal11eSerSerArgArgAspAsp-108 Hydrophilic Regions - Hopp-Woods 27-AspGlyHisGlyAspAspAspHisGlyHis-36 40-GlnHisGlyLysGlnAspLysIleIleSer-49 51-AlaGlnAlaGluLysAlaAla-57 61-ValGlyGlyLysIleThrAspIleAspLeuGluHisAspAspGlyArgProHisTyr-79 82-GluIleValLysAsnGlyGlnGluTyr-90 94-ValAspAlaArgThrGlyArg-100 102-IleSerSerArgArgAspAsp-108 g973 AMPHI Regions - AMPHI 12-GluArgLeuIleAlaArgLeuAlaArgGluProAspSerAlaGluAspValLeuAsnLeuLeuArgGlnAla- 35 44-AspThrLeuThrArgLeuGluLysValLeuAspPhe-55 77-AspSerIleGluArgIleThrAlaTyr-85 112-AspLeuLeuLysTyrMet-117 143-AlaLeuLeuLysGluPheArgGluGln-151 171-PheGluAspIleIleGluGlnIleValGlyAspIleGluAsp-184 190-GluSerAlaAspAspIleHisSerVal-198 208-AlaThrGluIleGluAspIleAsnAlaPhe-217 235-IleGlnGluLeuGly-239 Antigenic Index - Jameson-Wolf 1-MetAspGlyAlaGlnProLysThrAsnPhe-lO 18-LeuAlaArgGluProAspSerAlaGluAspVal-28 34-GlnAlaHisGluGlnGluValPheAspAlaAspThrLeuThrArgLeuGluLysValLeuAsp-54 56-AlaGluLeuGluValArgAspAlaMetIleThrArgSerArgMetAsnValLeuLysGluAsnAspSerIleG luArg-81 96-ValIleGlyGluAspLysAspGluVal-104 118-PheAsnProGluGlnPheHis-124 136-ProGluGlyLysSer-140 146-LysGluPheArgGluGlnArgAsnHis-154 159-IleAspGluTyrGlyGlyThrSerGly-167 178-IleValGlyAspIleGluAspGluPheAspGluAspGluSerAlaAspAspIleHis-196 199-SerAlaGluArgTrpArg-204 209-ThrGluIleGluAsp-213 219-GlyThrGluTyrGlySerGluGluAlaAspThr-229 239-GlyHisLeuProValArgGlyGluLysValLeu-249 258-AlaArgAlaAspAsnArgArgLeuHis-266 Hydrophilic Regions - Hopp-Woods 1-MetAspGlyAlaGlnProLys-7 18-LeuAlaArgGluProAspΞerAlaGluAspVal-28 34-GlnAlaHisGluGlnGluValPheAsp-42 44-AspThrLeuThrArgLeuGluLysValLeuAsp-54 56-AlaGluLeuGluValArgAspAlaMetIleThrArgSerArgMetAsnValLeuLysGluAsnAspSerIleG luArg-81 96-ValIleGlyGluAspLysAspGluVal-104 136-ProGluGlyLysSer-140 146-LysGluPheArgGluGlnArgAsn-153 178-IleValGlyAspIleGluAspGluPheAspGluAspGluSerAlaAspAspIleHis-196 199-SerAlaGluArgTrpArg-204 209-ThrGluIleGluAsp-213 222-TyrGlySerGluGluAlaAspThr-229 243-ValArgGlyGluLysValLeu-249 258-AlaArgAlaAspAsnArgArgLeuHis-266 g981 AMPHI Regions - AMPHI 32-AsnProGlyLysValTyrArgValAlaSer-41 46-AlaProPheGluSerLeuAsp-52 66-AsnAlaMetAlaLys-70 132-LysValSerSerSerGluAspLeuLysLysMetAsnLysValGly-146 167-LysIleAlaArgPheGlu-172 181-LeuGluAsnGlyGlyLeuAspSerValVal-190 197-AlaAsnTyrValLysAsnAsnPro-204 207-GlyMetAspPheValThrLeuPro-214 233-ValLysMetLeuAsnAspAlaLeuGluLysValArgGluSerGlyGluTyr-249 Antigenic Index - Jameson-Wolf 19-CysGlyGlyGlnGlyLysAspAlaAlaAla-28 30-AlaAlaAsnProGlyLysValTyrArg-38 49-GluSerLeuAspSerLysGlyAsnValGluGlyPheAsp-61 76-IleGluPheLysHisGlnProTrpAspSer-85 90-LeuAsnAsnGlyAspAlaAspVal-97 104-IleThrAspAspArgLysGlnSerMetAspPheSerAspProTyrPhe-119 127-ValProLysGlyLysLysValSerSerSerGluAspLeuLysLysMetAsnLysValGly-146 149-ThrGlyHisThrGlyAspPheSerVal-157 159-LysLeuLeuGlyAsnAspAsnProLysIleAlaArg-170 179-LysGluLeuGluAsnGlyGlyLeuAspSerValValSerAspSerAla-194 201-LysAsnAsnProAlaLysGlyMetAspPhe-210 214-ProAspPheThrThr-218 225-ValArgLysGlyAspGluAlaThrVal-233 235-MetLeuAsnAspAlaLeuGluLysValArgGluSerGlyGluTyrAspLysIleTyr-253 257-PheAlaLysGluGlyGlyGlnAlaAlaLys-266 Hydrophilic Regions - Hopp-Woods 21-GlyGlnGlyLysAspAlaAlaAla-28 49-GluSerLeuAspSerLysGlyAsnValGluGlyPheAsp-61 91-AsnAsnGlyAspAlaAspVal-97 104-IleThrAspAspArgLysGlnSerMetAspPheSer-115 128-ProLysGlyLysLysValSerSerSerGluAspLeuLysLysMetAsnLys-144 164-AspAsnProLysIleAlaArg-170 179-LysGluLeuGluAsnGlyGlyLeu-186 203-AsnProAlaLysGlyMetAsp-209 225-ValArgLysGlyAspGluAlaThrVal-233 235-MetLeuAsnAspAlaLeuGluLysValArgGluSerGlyGluTyrAspLysIleTyr-253 257-PheAlaLysGluGlyGlyGlnAlaAlaLys-266 g982 AMPHI Regions - AMPHI 10-ArgPheLeuGlnLysMetValAsnGlyValAsnIleLeuProAlaAlaAspTrp-27 70-AlaGlnMetValLysGluValAlaSerLysThr-80 99-ValAlaGluGlyMetLysTyr-105 114-AspLeuLysArgGlyIleAspLysAlaValAlaAlaLeuValGluGluLeuLysAsnIleAlaLysProCys AspThrSerLysGluIleAlaGlnValGlySer-148 159-AlaIleIleAlaGluAlaMetGluLysValGly-169 184-AsnGluLeuAspValValGluGlyMet-192 208-GluLysGlnIleAlaGlyLeuAsp-215 226-IleSerAsnIleArgAspLeuLeuProValLeuGluGlnValAlaLysAla-242 264-AsnAsnIleArgGlyIleLeuLysThrValAla-274 312-ThrLeuAspAspLeuGlyGlnThrLysArg-321 330-ThrValIleAspGlyPheGlyAspAlaAla-339 366-GluArgValAlaLysLeuAlaGlyGlyVal-375 425-LeuGluAsnLeuHisThr-430 443-LeuArgAlaValGluSerProLeuArgGlnIleValAlaAsnAla-457 483-GluTyrGlyAspMetIleGlyMet-490 499-ThrArgSerAlaLeu-503 Antigenic Index - Jameson-Wolf l-AlaSerGlnAsnLeuArgPheAspAsnArgPheLeu-12 31-GlyAlaLysGlyArgAsnValValVal-39 42-AlaPheGlyGlyProHisIleThrLysAspGlyValThrValAlaLysGluIleGluLeuLysAspLysPheG luAsnMetGly-69 72-MetValLysGluValAlaSerLysThrAsnAspValAlaGlyAspGlyThrThr-89 111-AsnProThrAspLeuLysArgGly11eAspLysAlaVal-123 128-GluGluLeuLysAsnIleAlaLysProCysAspThrSerLysGluIleAla-144 149-IleSerAlaAsnSerAspGluGlnVal-157 163-GluAlaMetGluLysValGlyLysGluGlyValIleThrValGluAspGlyLysSerLeuGluAsnGluLeu AspVal-188 192-MetGlnPheAspArgGlyTyr-198 206-AspAlaGluLysGlnIleAla-212 222-PheAspLysLysIleSerAsnIleArgAsp-231 238-GlnValAlaLysAlaSerArg-244 251-GluAspValGluGlyGluAla-257 265-AsnIleArgGlyIleLeu-270 277-AlaProGlyPheGlyAspArgArgLysAlaMetLeu-288 300-IleSerGluGluValGlyLeuSerLeuGluLysAlaThrLeuAspAspLeuGlyGlnThrLysArgIleGlu IleGlyGluGluAsnThrThr-330 333-AspGlyPheGlyAspAlaAlaGlnIleGluAlaArgValAlaGluIleArgGlnGlnIleGluThrAlaThr SerAspTyrAspLysGluLysLeuGlnGluArgValAlaLysLeuAlaGly-373 384-ThrGluValGluMetLysGluLysLysAspArgValGluAspAlaLeuHis-400 404-AlaAlaValGluGluGlyVal-410 420-ArgAlaArgAlaAlaLeu-425 428-LeuHisThrGlyAsnAlaAspGlnAspAlaGlyVal-439 445-AlaValGluSerProLeuArg-451 456-AsnAlaGlyGlyGluProSerVal-463 468-ValLeuGluGlyLysGlyAsnTyrGlyTyr-477 479-AlaGlySerGlyGluTyrGlyAsp-486 494-AspProAlaLysValThrArgSerAlaLeu-503 522-GluIleProGluGluLysProAlaValProAspMetGlyGly-535 Hydrophilic Regions - Hopp-Woods 5-LeuArgPheAspAsn-9 32-AlaLysGlyArgAsnValValVal-39 47-HisIleThrLysAspGlyValThrValAlaLysGluIleGluLeuLysAspLysPheGluAsn-67 72-MetValLysGluValAlaSerLysThrAsnAspValAlaGlyAspGlyThrThr-89 113-ThrAspLeuLysArgGlyIleAspLysAlaVal-123 128-GluGluLeuLysAsnIleAlaLysProCysAspThrSerLysGluIleAla-144 151-AlaAsnSerAspGluGlnVal-157 163-GluAlaMetGluLysValGlyLysGluGlyValIleThrValGluAspGlyLysSerLeuGluAsnGluLeu AspVal-188 206-AspAlaGluLysGlnIleAla-212 222-PheAspLysLysIleSerAsnIleArgAsp-231 238-GlnValAlaLysAlaSerArg-244 251-GluAspValGluGlyGluAla-257 279-GlyPheGlyAspArgArgLysAlaMetLeu-288 300-IleSerGluGluValGlyLeuSerLeuGluLysAlaThrLeuAspAspLeuGlyGlnThrLysArgIleGlu 11eGlyGluGluAsnThrThr-330 339-AlaGlnIleGluAlaArgValAlaGluIleArgGlnGlnIleGluThrAlaThrSerAspTyrAspLysGlu LysLeuGlnGluArgValAlaLys-370 384-ThrGluValGluMetLysGluLysLysAspArgValGluAspAlaLeuHis-400 404-AlaAlaValGluGluGlyVal-410 420-ArgAlaArgAlaAlaLeu-425 431-GlyAsnAlaAspGlnAspAla-437 445-AlaValGluSerProLeu-450 457-AlaGlyGlyGluPro-461 468-ValLeuGluGlyLysGly-473 480-GlySerGlyGluTyrGlyAsp-486 494-AspProAlaLysValThrArg-500 522-GluIleProGluGluLysProAlaVal-530 g986 AMPHI Regions - AMPHI 6-GlnTyrPheAlaLeuAlaAlaLeuCysAlaAlaLeuLeuAla-19 21-CysGluLysAlaGly-25 36-SerPheValGluArgIleGluHis-43 55-ProAspPheAlaGlnLeuValGln-62 97-AspProPheTyrGluPhePheLysArgLeuValProAsnMetProGluIleProGln-115 145-AlaGlyMetGlySerIle-150 162-AlaLysLeuIleGlySerAspVal-169 189-IleGlyAsnProLysAsnLeuLysProGly-198 200-TrpValAlaAlaIleGly-205 287-AlaGluGlnLeuLysAsnThrGlyLysVal-296 393-AlaAlaGluHisThrGly-398 471-ArgLysAlaMetAspLysAla-477 Antigenic Index - Jameson-Wolf 20-GlyCysGluLysAlaGlySer-26 29-GlyAlaAspLysLysGluAlaSerPheValGluArgIleGluHisThrLysAspAspGlySerVal-50 61-ValGlnSerGluGlyProAla-67 75-ProAlaProArgThrGlnAsnGlySerGlyAsnAlaGluThrAspSerAspProLeuAlaAspSerAspProP he-99 104-LysArgLeuValProAsnMetProGluIleProGlnGluGluAlaAspAspGlyGlyLeu-123 154-LeuAsnAspLysArgGluTyrThr-161 165-IleGlySerAspValGlnSerAspValAla-174 179-AspAlaThrGluGluLeuPro-185 189-IleGlyAsnProLysAsnLeuLysProGlyGlu-199 208-PheGlyPheAspAsnSerVal-214 219-ValSerAlaLysGlyArgSerLeuProAsnGluSerTyr-231 242-AsnProGlyAsnSerGlyGlyPro-249 265-TyrSerArgSerGlyGly-270 288-GluGlnLeuLysAsnThrGlyLysValGlnArgGlyGlnLeu-301 316-PheGlyLeuAspLysAlaSerGly-323 330-LeuProGlySerProAlaGluArgAlaGlyLeuGlnAlaGlyAsp-344 349-LeuAspGlyGlyGluIleArgSerSerGlyAspLeu-360 368-ThrProGlyLysGluValSer-374 378-TrpArgLysGlyGluGluIleThrIle-386 394-AlaGluHisThrGlyAlaSerSerLysThrAspGluAlaProTyrThrGluGlnGlnSerGlyThrPhe-41 6 427-ThrHisThrAspSerSerGlyLysHis-435 440-ArgValSerAspAlaAlaGluArgAlaGlyLeuArgArgGlyAspGluIleLeu-457 463-ProValAsnAspGluAlaGlyPheArgLysAlaMetAspLysAlaGlyLysAsnVal-481 486-MetArgArgGlyAsnThr-491 Hydrophilic Regions - Hopp-Woods 20-GlyCysGluLysAlaGly-25 29-GlyAlaAspLysLysGluAlaSerPheValGluArgIleGluHisThrLysAspAspGlySer-49 75-ProAlaProArgThrGlnAsnGlySerGlyAsnAlaGluThrAspSerAspProLeuAlaAspSerAspPro- 98 lll-ProGluIleProGlnGluGluAlaAspAspGlyGly-122 154-LeuAsnAspLysArgGluTyrThr-161 179-AspAlaThrGluGluLeuPro-185 193-LysAsnLeuLysPro-197 221-AlaLysGlyArgSerLeuPro-227 288-GluGlnLeuLysAsnThrGlyLysValGlnArgGlyGln-300 317-GlyLeuAspLysAlaSer-322 333-SerProAlaGluArgAlaGlyLeuGln-341 350-AspGlyGlyGluIleArgSerSerGlyAsp-359 368-ThrProGlyLysGluValSer-374 379-ArgLysGlyGluGluIleThrIle-386 394-AlaGluHisThrGlyAlaSerSerLysThrAspGluAlaProTyrThrGluGlnGlnSer-413 428-HisThrAspSerSerGly-433 440-ArgValSerAspAlaAlaGluArgAlaGlyLeuArgArgGlyAspGluIleLeu-457 463-ProValAsnAspGluAlaGlyPheArgLysAlaMetAspLysAlaGlyLys-479 g987 AMPHI Regions - AMPHI 17-CysSerSerTrpLeu-21 65-ProHisGluAlaPhe-69 121-AsnThrArgGly-124 135-HisProAsnIleValArgLeuPheAsnProPheValLeuArgLysTrpArgAlaLeuGlyTyrLeuThrAsp PheProArgLeuAsnArg-164 186-GlyAspGluTyrPheLysVal-192 201-LeuAspIleLeuAlaThr-206 210-ValGlyGluValSerHisAspPheAspArgTyrTrpAla-222 229-AlaThrArgIleIleArgSerGly-236 238-IleGlyLysGlyLeuGlnAla-244 288-SerAspSerProAlaLysGlyLeuAspArg-297 306-GlyArgLeuGlnAspAlaLeuLysGlnPro-315 332-GlyThrAspAlaLeuAlaLysLeuValGlnAsp-342 354-GlnAlaThrAspValAlaAla-360 442-LysIleAlaGluGlnMetGluArgThrLeuAlaAspThrThrPro-456 485-ProGluAlaLysLeuTrpLysArgIleAlaAlaLysIleLeuSerLeuLeuProIleGluGlyLeu-506 Antigenic Index - Jameson-Wolf 1-MetLysThrArgSer-5 23-ProLeuGluGluArgThrGluSerArgHisPheAsnThrSerLysProValLeu-40 49-HisThrProHisAsnAsnGlyLeuSer-57 77-GluSerAlaGluHisSerLeu-83 90-TrpArgAsnAspIleSerGlyArgLeu-98 107-AlaGluArgGlyValArg-112 115-LeuLeuLeuAspAspAsnAsnThrArgGlyLeuAsp-126 134-SerHisProAsnIle-138 158-AspPheProArgLeuAsnArgArgMetHisAsnLysSerPheThrAlaAspAsnArgAla-177 181-GlyGlyArgAsnIleGlyAspGluTyrPheLysValGlyGluAspThrVal-197 213-ValSerHisAspPheAspArgTyrTrp-221 224-HisSerAlaHisAsn-228 231-ArgIleIleArgSerGlyAsnIleGlyLysGlyLeu-242 246-GlyTyrAsnAspGluThrSerArg-253 258-ArgTyrArgGluThrValGlu-264 266-SerProLeuTyrGln-270 272-IleGlnThrGlyArgIleAsp-278 286-LeuIleSerAspSerProAlaLysGlyLeuAspArgAspArgArgLysProProIle-304 307-ArgLeuGlnAspAlaLeuLysGlnProGluLysSer-318 327-ValProThrLysSerGlyThrAspAlaLeu-336 339-LeuValGlnAspGlyIleAsp-345 366-ValLysTyrArgLysProLeuLeu-373 390-AlaThrLysAspLysGlyLeuThrGlySerSerVal-401 411-ValAspGlyLysArgIlePhe-417 421-PheAsnLeuAspProArgSerAlaArgLeuAsnThr-432 439-GluSerProLysIleAlaGluGlnMetGluArgThrLeuAlaAspThrThrProGluTyrAlaTyr-460 462-ValThrLeuAspLysHisAsnArgLeuGlnTrpHisAspProAlaThrArgLysThrTyrProAsnGluPro GluAlaLysLeuTrpLys-491 Hydrophilic Regions - Hopp-Woods l-MetLysThrArgSer-5 24-LeuGluGluArgThrGluSerArgHisPheAsnThr-35 77-GluSerAlaGluHisSerLeu-83 107-AlaGluArgGlyValArg-112 115-LeuLeuLeuAspAspAsnAsnThrArgGlyLeuAsp-126 160-ProArgLeuAsnArgArgMetHisAsn-168 171-PheThrAlaAspAsnArgAla-177 188-GluTyrPheLysValGlyGluAspThrVal-197 213-ValSerHisAspPheAspArg-219 247-TyrAsnAspGluThrSerArg-253 258-ArgTyrArgGluThrValGlu-264 273-GlnThrGlyArgIleAsp-278 290-SerProAlaLysGlyLeuAspArgAspArgArgLysProProIle-304 307-ArgLeuGlnAspAlaLeuLysGlnProGluLysSer-318 330-LysSerGlyThrAspAlaLeu-336 339-LeuValGlnAspGlyIleAsp-345 366-ValLysTyrArgLysProLeuLeu-373 390-AlaThrLysAspLysGlyLeuThr-397 423-LeuAspProArgSerAlaArgLeuAsnThr-432 439-GluSerProLysIleAlaGluGlnMetGluArgThrLeuAla-452 463 -ThrLeuAspLysHisAsnArg-469 475-ProAlaThrArgLysThrTyrProAsnGluProGluAlaLysLeuTrpLys-491 g988 AMPHI Regions - AMPHI 45-SerLysIleGluSerLeuAlaArg-52 125-GlnMetArgGlyVal-129 154-AspIleValGluArgAlaGlnSerLysVal-163 221-AlaLysIleIleGluValLeuGlyAspTyrAlaAsp-232 248-HisArgPheSerGluAlaCysAlaLysSerAlaLysLysIleProAspHisValArgLys-267 288-ThrAlaArgAspPheAspAsp-294 299-GluLysValGlyArgAsnTyr-305 310-AlaIleAlaAspValSerHisTyrValArgProAspAsp-322 348-AsnLeuSerAsnGly-352 396-AsnGlnValTrpLysTrpLeuSerAspGlyIleGlyAsnProHisLys-411 413-GlnIleAspThrLeuTyrLysLeuPheLysIleLeuGlnLys-426 494-LeuGlyProThrProGluLysLeuAlaThrLeu-504 524-LysAspTyrAlaAlaLeuAlaGluGlnPheLys-534 544-ValMetMetLeuArgSerMetGlnGlnAla-553 555-TyrGluProHisCys-559 569-AlaTyrAlaHisPheThrSerProIleArgArgTyrProAspLeuThrValHisArgAlaIleLysAlaVal -592 618-AlaAspAspAlaGlyArgAspValGluAsnTrpLeuLys-630 641-IlePheGluGlyLysIleSerArgGly-649 653-PheGlyIlePheValThrLeu-659 667-LeuValHisIleSerAspLeuGlyGlu-675 Antigenic Index - Jameson-Wolf l-MetAsnLysAsnIleLys-6 8-LeuAsnLeuArgGluLysAspProPheLeuSerArgGluLysGlnArgTyrGluHisProLeuProSerArgGl uTrpIle-34 37-LeuLeuGluArgLysGlyValProSerLysIleGluSerLeuAlaArgGluLeuSerIleThrGluAspGluT yrValPhePheGluArgArgLeuLysAlaMetAlaArgAspGlyGln-76 79-IleAsnArgArgGlyAlaVal-85 87-AlaAlaAspLysLeuAspLeuValLysCysArgValGluAlaHisLysAspGlyPhe-105 113-ProMetAspGluGlyAsp-118 124-ArgGlnMetArgGlyValMetHisGlyAspThrValThr-136 138-ArgProAlaGlyMetAspArgArgGlyArgArgGluGlyThrPhe-152 154-AspIleValGluArgAlaGlnSerLysValVal-164 168-TyrMetAspArgGlyValAla-174 176-LeuGluProGluAspLysArgLeuAsnGlnSerIle-187 189-LeuGluProAspGlyValAlaArgPheLysProGluSerGlyGln-203 210-GluValTyrProGluGlnAsnArgProAlaVal-220 227-LeuGlyAspTyrAlaAspSerGlyMetGluIle-237 239-IleAlaValArgLysHisHisLeuProHisArgPheSerGluAlaCysAlaLysSerAlaLysLysIlePro AspHisValArgLysSerAspLeuLysGlyArgValAspLeuCys-277 283-ThrIleAspGlyGluThrAlaArgAspPheAspAsp-294 299-GluLysValGlyArgAsnTyrArg-306 316-HisTyrValArgProAspAspAlaIleAspAlaAspAlaGlnGluArgSerThrSerValTyrPheProArg ArgMetIleProMetLeuProGluAsnLeuSerAsnGlyIleCysSerLeuAsnProAspValGluArgLeu-363 374-AlaGlyAsnIleLysGluTyrArgPhe-382 393-LeuThrTyrAsnGln-397 402-LeuSerAspGlyIleGlyAsnProHisLysAlaGlnIle-414 424-LeuGlnLysLysArgLeuAlaArgGlyAlaValGluPheGluSerValGlu-440 443-MetIlePheAspAspAsnGlyLysIleGluLys-453 458-ValArgAsnAspAlaHisLysLeuIleGlu-467 482-LeuLysAsnLysHisThrAla-488 493-HisLeuGlyProThrProGluLysLeuAlaThrLeuArgGluGlnLeu-508 516-GlyGlyGlyAspAsnProSerProLysAspTyrAlaAla-528 531-GluGlnPheLysGlyArgProAspAlaGluLeu-541 555-TyrGluProHisCysGluGlyHis-562 575-SerProIleArgArgTyrProAspLeuThrVal-585 592-ValLeuAsnArgLysThrTyrThrProAsnLysSerTrp-604 613-PheCysGluArgArgAlaAspAspAlaGlyArgAspValGluAsn-627 633-TyrMetArgAspLysValGlyGluIlePheGluGlyLysIleSerArgGlyValAla-651 671-SerAspLeuGlyGluAspTyrPheAsnPheArgPro-682 684-IleMetAlaIleGluGlyGluArgSerGlyIleArgPheAsnMetGlyAspArgValAlaValArgValAla ArgAlaAspLeuAspAspGlyLysIle-716 724-GluSerGlyArgArgArgLysValLysLeu-733 735-AlaSerAlaLysProAlaGlyAlaAlaGlyLysGlyLysSerLysThrThrAlaGluLysLysThrAlaArg CysGlyLysValArgGlyArgGlyValProAla-769 771-AlaGluSerGlyLysLysAlaLysLysProValProIleLysValLysLysArgLysGlyLysSer-792 Hydrophilic Regions - Hopp-Woods 1-MetAsnLysAsnl1eLys-6 8-LeuAsnLeuArgGluLysAspProPheLeuSerArgGluLysGlnArgTyrGluHis-26 37-LeuLeuGluArgLysGlyValProSerLysIleGluSerLeuAlaArgGluLeuSerIleThrGluAspGluT yrValPhePheGluArgArgLeuLysAlaMetAlaArgAspGlyGln-76 79-IleAsnArgArgGlyAla-84 87-AlaAlaAspLysLeuAspLeuValLysCysArgValGluAlaHisLysAspGlyPhe-105 113-ProMetAspGluGlyAsp-118 140-AlaGlyMetAspArgArgGlyArgArgGluGlyThr-151 155-IleValGluArgAlaGlnSerLysValVal-164 176-LeuGluProGluAspLysArgLeuAsn-184 189-LeuGluProAspGlyValAlaArgPheLysProGluSerGly-202 210-GluValTyrProGluGlnAsnArgProAlaVal-220 230-TyrAlaAspSerGlyMetGluIle-237 239-IleAlaValArgLysHisHisLeu-246 249-ArgPheSerGluAlaCysAlaLysSerAlaLysLysIleProAspHisValArgLysSerAspLeuLysGly ArgValAspLeu-276 284-IleAspGlyGluThrAlaArgAspPheAspAsp-294 299-GluLysValGlyArgAsnTyr-305 318-ValArgProAspAspAlaIleAspAlaAspAlaGlnGluArgSerThr-333 358-ProAspValGluArg-362 376-AsnIleLysGluTyrArg-381 406-IleGlyAsnProHisLysAlaGlnIle-414 424-LeuGlnLysLysArgLeuAlaArgGlyAlaValGluPheGluSerValGlu-440 443-MetIlePheAspAspAsnGlyLysIleGluLys-453 458-ValArgAsnAspAlaHisLysLeuIleGlu-467 496-ProThrProGluLysLeuAlaThrLeuArgGluGlnLeu-508 517-GlyGlyAspAsnProSerProLysAspTyrAlaAla-528 531-GluGlnPheLysGlyArgProAspAlaGluLeu-541 576-ProIleArgArgTyrProAsp-582 592-ValLeuAsnArgLysThrTyrThrPro-600 613-PheCysGluArgArgAlaAspAspAlaGlyArgAspValGluAsn-627 633-TyrMetArgAspLysValGlyGluIlePheGluGlyLysIleSerArg-648 684-IleMetAlaIleGluGlyGluArgSerGlyIle-694 697-AsnMetGlyAspArgValAlaValArgValAlaArgAlaAspLeuAspAspGlyLysIle-716 724-GluSerGlyArgArgArgLysValLysLeu-733 735-AlaSerAlaLysProAlaGlyAlaAlaGlyLysGlyLysSerLysThrThrAlaGluLysLysThrAlaArg CysGlyLysValArgGlyArgGly-766 771-AlaGluSerGlyLysLysAlaLysLysProValProIleLysValLysLysArgLysGlyLysSer-792 g989 AMPHI Regions - AMPHI 36-AlaGlnSerThrAlaAsnAlaAla-43 53-AlaGlyLeuThrLysLeu-58 80-SerAlaThrAspPhe-84 104-ProHisIleTyrGlyAla-109 178-GluLeuArgLysTyrAlaAspGlyIle-186 195-AlaThrProSerAsnProThr-201 287-ValThrProGluSer-291 293-SerValHisGlyMetTyrLysValSer-301 312-TrpThrArgHisSerArg-317 357-SerTyrGlnIleSerGluPro-363 439-SerCysAlaArgPheLysAsnHisAlaAsp-448 Antigenic Index - Jameson-Wolf 41-AsnAlaAlaAspAlaSer-46 52-ProAlaGlyLeuThrLysLeuAspSerSerGlnIle-63 76-TyrGluAlaAspSerAlaThrAspPheThr-85 89-ValGlnGlySerLysAsnGlyLysIleThrLysThrThr-101 lll-LysValAsnAspAsnLeuThr-117 127-GlySerAlaThrGluTyrGluLysAspSerValLeu-138 141-AsnIleAsnLysLeuGly-146 159-LysLeuAsnGluArgHisSerPheGly-167 174-HisAsnSerAlaGluLeuArgLysTyrAlaAspGlyIleProLysLysAlaGln-191 196-ThrProSerAsnPro-200 206-IleLysAlaAspGlyHisAlaAspValLysGlySerAspTrpGly-220 230-AspIleAsnAspArgAlaArgValGlyValAsnTyrArgSerLysValSerHisThrLeuLysGlyAspAla GluTrpAlaAla-257 259-GlyAlaAlaAlaLysGlnGlnTrpAsnAspAsnMet-270 278-AlaAsnGluLysAlaSerVal-284 287-ValThrProGluSer-291 298-TyrLysValSerAspLysAlaAspLeu-306 313-ThrArgHisSerArgPheAsnLys-320 323-LeuPhePheGluLysGluLysAsnIleAlaAsnGlyLysLysSerAspArgThrThrIleThrProAsnTrp ArgAsnThrTyrLys-351 353-GlyLeuGlyGlySerTyrGlnIleSerGlu-362 372-PheAspLysProProValArgAsnAlaAspTyrArgMetAsnSerLeuProAspGlyAsnArg-392 402-HisIleGlyLysAsnHisVal-408 419-AsnAspThrSerTyrArgThrAlaLysAlaSerGlyAsnAspValAspSerLysGlyAlaSerCysAlaArg PheLysAsnHisAla-447 Hydrophilic Regions - Hopp-Woods 56-ThrLysLeuAspSerSerGln-62 76-TyrGluAlaAspSerAlaThr-82 90-GlnGlySerLysAsnGlyLys11eThrLys-99 130-ThrGluTyrGluLysAspSerValLeu-138 159-LysLeuAsnGluArgHisSer-165 175-AsnSerAlaGluLeuArgLysTyrAlaAspGlyIleProLysLysAlaGln-191 206-IleLysAlaAspGlyHisAlaAspValLysGlySerAsp-218 231-IleAsnAspArgAlaArgVal-237 241-TyrArgSerLysVal-245 249-LeuLysGlyAspAlaGluTrpAlaAla-257 278-AlaAsnGluLysAlaSerVal-284 299-LysValSerAspLysAlaAspLeu-306 316-SerArgPheAsnLys-320 323-LeuPhePheGluLysGluLysAsnIleAlaAsnGlyLysLysSerAspArgThrThrIle-342 372-PheAspLysProProValArgAsnAlaAspTyrArgMet-384 386-SerLeuProAspGlyAsn-391 421-ThrSerTyrArgThrAlaLysAlaSerGlyAsnAspValAspSerLysGlyAlaSer-439 441-AlaArgPheLysAsnHisAla-447 g992 AMPHI Regions - AMPHI 6-ArgHisLeuLysAsnMetGlnIleLysLysIleMetLysTrp-19 24-LeuSerLeuLeuGlyAlaLeuGlyTyr-32 45-AlaValLeuAspValLeuGlyThr-52 72-HisSerTyrThrGlyThrValSerLysValTyr-82 140-TyrGlnArgGluValAlaGlnVal-147 158-GlnValGlnAspGly-162 179-AspPheAlaAspTyr-183 Antigenic Index - Jameson-Wolf l-MetPheArgArgHisArgHisLeuLys-9 33-ThrGlyTyrAspSerGluAlaValArg-41 51-GlyThrAlaGlyAspValGlyPhe-58 60-AlaProValArgArgArgAlaSerAlaLysSerGlyHisSerTyr-74 79-SerLysValTyrAspGlyAspThr-86 90-IleAspGlyAspGlyAlaLysHisLysIle-99 105-AspAlaProGluMetLysGlnAlaTyrGlyThrArgSerArgAspAsnLeuArgAlaAlaAlaGluGlyArg LysValSer-131 134-ValPheGluThrAspArgTyrGlnArgGluValAla-145 148-SerAlaGlyLysThrAspLeu-154 168-LysSerTyrAlaLysGluGlnGlnAspLysAlaAspPhe-180 187-GlnIleGlnAlaGluArgGluArgLysGlyLeuTrpLysAlaLysAsnProGlnAlaPro-206 208-AlaTyrArgArgAlaGlyArgSerGlyGlyGlyAsnLysAspTrpMetAspΞerValGlyGlu-228 Hydrophilic Regions - Hopp-Woods l-MetPheArgArgHisArgHisLeuLys-9 35-TyrAspSerGluAlaValArg-41 60-AlaProValArgArgArgAlaSerAlaLysSerGlyHis-72 80-LysValTyrAspGlyAspThr-86 90-IleAspGlyAspGlyAlaLysHisLysIle-99 105-AspAlaProGluMetLysGln-lll 113-TyrGlyThrArgSerArgAspAsnLeuArgAlaAlaAlaGluGlyArgLysValSer-131 134-ValPheGluThrAspArgTyrGlnArgGluValAla-145 148-SerAlaGlyLysThrAspLeu-154 169-SerTyrAlaLysGluGlnGlnAspLysAlaAspPhe-180 187-GlnIleGlnAlaGluArgGluArgLysGlyLeuTrpLysAlaLysAsnPro-203 211-ArgAlaGlyArgSerGlyGlyGlyAsnLysAspTrpMetAspSerVal-226 g993 AMPHI Regions - AMPHI 6-GlySerPheGlnGlyProLeuAspLeuLeuLeu-16 35-ThrGlyGlnTyrLeuHisTyrIleAlaGlnMet-45 105-GlyLeuAspAlaLeuProArgAla-112 133-GluValTyrIleAlaAspLeuMetGlnAlaTrpLeuGly-145 152-HisThrArgSerHisGluValIle-159 169-MetThrAlaIleLeuArgArgLeuAsnGluHisGlyIleCysArgPheHisAlaLeuPheAsn-189 198-IleValAsnPheIleAlaLeuLeu-205 Antigenic Index - Jameson-Wolf 7-SerPheGlnGlyProLeu-12 20-ArgLysGlnAsnlleAsp-25 70-LeuLeuLeuProArgThrGluAlaValGluAspGluGluAlaAspProArgAlaGluLeuValArg-91 108-AlaLeuProArgAlaGlyArgAspPhe-116 125-IleAlaAlaGluThrLysLeuPro-132 148-SerArgAlaLysHisThrArgSerHisGluValIleGln-160 174-ArgArgLeuAsnGluHisGlyIle-181 189-AsnProGluGlnGly-193 207-LeuAlaLysGluGlyLeu-212 216-ValGlnGluAspGlyPheGlyGluIleArgIle-226 228-LeuAsnHisGluGlyAlaHisSerAspGlyIlePheGlyThrArgGlyGlyArgAspValPhe-248 Hydrophilic Regions - Hopp-Woods 20-ArgLysGlnAsnlleAsp-25 70-LeuLeuLeuProArgThrGluAlaValGluAspGluGluAlaAspProArgAlaGluLeuValArg-91 108-AlaLeuProArgAlaGlyArg-114 125-IleAlaAlaGluThrLysLeuPro-132 148-SerArgAlaLysHisThrArgSerHisGluValIleGln-160 174-ArgArgLeuAsnGlu-178 207-LeuAlaLysGluGlyLeu-212 216-ValGlnGluAspGlyPheGly-222 242-ArgGlyGlyArgAspValPhe-248 g996 AMPHI Regions - AMPHI 21-LysSerAlaArgThrHisAlaLysIlePro-30 50-ProGlyGluSerTyrProAlaGlnLeuGlnLysLeuThrGlyTrpAsn-65 75-ThrSerAlaGlnAlaLeuSerArgLeuProAla-85 104-LeuArgLysValProGluGlu-llO 115-AsnIleAlaLysIleIleGluThrValGlnLys-125 140-LeuGlyAlaLeuPheGlyHisLeuSerAsp-149 167-GlyAlaTrpAlaGlu-171 186-AsnGlyLysGlyTyrArgLysPheAlaGluAsnLeuAsnGlnPheLeuArgLysHisGlyPhe-206 Antigenic Index - Jameson-Wolf 1-MetAsnArgArgThrPhe-6 18-CysGlyArgLysSerAlaArgThrHisAlaLysIleProGluGlySerThr-34 46-TyrGlyAlaAsnProGlyGluSerTyrPro-55 69-GlyGlyValSerGlyAspThrSerAla-77 87-LeuAlaArgLysProLys-92 99-GlyGlyAsnAspPheLeuArgLysValProGluGluGlnThrArgAlaAsnl1e-116 121-GluThrValGlnLysGluAsnIle-128 148-SerAspHisProLeuTyrGluAspLeuSerGluGluTyrGly-161 174-GlyAsnAsnAsnLeuLysSerAspGlnIleHisAlaAsnGlyLysGlyTyrArgLysPheAlaGluAsnLeu AsnGlnPheLeuArgLysHisGlyPheArg-207 Hydrophilic Regions - Hopp-Woods 18-CysGlyArgLysSerAlaArgThrHisAlaLysIleProGlu-31 49-AsnProGlyGluSerTyr-54 71-ValSerGlyAspThrSerAla-77 87-LeuAlaArgLysProLys-92 102-AspPheLeuArgLysValProGluGluGlnThrArgAlaAsnl1e-116 121-GluThrValGlnLysGluAsnIle-128 154-GluAspLeuSerGluGluTyrGly-161 177-AsnLeuLysSerAspGlnIleHisAlaAsn-186 188-LysGlyTyrArgLysPheAlaGlu-195 g997 AMPHI Regions - AMPHI 18-TrpAlaGlyLeuSerAlaAlaVal-25 70-TyrArgGlyValLeuArgLeuMetLysThrIleGly-81 107-ProLeuProAlaProLeuHisIle-114 123-ArgValProSerAlaPheLysAlaLysLeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGly -146 164-AlaAlaValMetGlnPheTrpGlnProLeuValTrpGly-176 189-ValLeuCysAsnValLeuSerAsp-196 222-AlaLeuAlaGluLeuGlnArg-228 241-ArgLeuAsnThrLeuPro-246 275-GluGlyThrProGluHisValGlnThrAla-284 300-TyrAlaGluProValArgLeuProAlaProLeuThrGlyIleAlaAspGly-316 Antigenic Index - Jameson-Wolf 3-AsnThrProHisProArgProLysIle-ll 37-GluAlaGlyArgGlnAlaGlyGlyArgAlaArgThrLeuAlaGlyAsnThrAspGlyPheGly-57 78-LysThrIleGlyΞerAspProArgAlaAla-87 122-ArgArgValProSerAlaPheLys-129 132-LeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGlyGlnProAspThrThr-151 156-LeuLysGlnArgAsnValProArg-163 180-ThrProLeuGluThrAlaSer-186 197-GlyValLeuThrLysLysSerGlySerAspTyrLeuLeuProLysGlnAspLeu-214 225-GluLeuGlnArgLeuGlyAlaAspIleArgLeuGluThrArgValCysArg-241 243-AsnThrLeuProAspGlyLysVal-250 273-LeuProGluGlyThrProGluHisVal-281 324-ProGlyGlnAlaProAspCysProGlnAsnGluValSer-336 341-ValSerAspArgValGlyAlaPheAlaAsnArgTerTerTerTer-355 Hydrophilic Regions - Hopp-Woods 5-ProHisProArgProLysIle-ll 37-GluAlaGlyArgGlnAlaGlyGlyArgAlaArgThrLeuAlaGlyAsn-52 80-IleGlySerAspProArgAlaAla-87 122-ArgArgValProSer-126 132-LeuLeuAlaAspMetSerAspLeuGlnLysSerAlaArgLeuGlyGlnProAspThrThr-151 198-ValLeuThrLysLysSerGlySer-205 208-LeuLeuProLysGlnAspLeu-214 225-GluLeuGlnArgLeuGlyAlaAspIleArgLeuGluThrArgValCysArg-241 246-ProAspGlyLysVal-250 276-GlyThrProGluHisVal-281 326-GlnAlaProAspCysProGlnAsnGluVal-335 341-ValSerAspArgValGly-346 It will be understood that the invention is described above by way of example only and modifications may be made whilst remaining within the scope and spirit of the invention.

Claims: CLAIMS 1. A fragment of a protein disclosed in international patent application WO99/57280 or WO00/22430, wherein the fragment comprises at least one antigenic determinant. 2. The fragment of claim 1, having a length of 100 amino acids or less. 3. The fragment of claim 1 or claim 2, having a length of 5 amino acids or greater. 4. The fragment of any preceding claim, having an amino acid sequence disclosed in Table I. 5. A polypeptide having 50% or greater sequence identity to the fragment of any preceding claim. 6. A protein comprising one or more fragment of claim 1, claim 2 or claim 3, with the proviso that the protein is not one of the complete protein sequences disclosed in international patent application WO99/57280 or WO00/22430. 7. An antibody which recognises the fragment according to any one of claims 1 to 6. 8. A protein comprising a peptide sequence, wherein the peptide sequence is recognised by an antibody according to claim 7. 9. Nucleic acid encoding the fragment of claim 1, claim 2 or claim 3, the polypeptide of claim 5, or the protein of claim 6 or claim 8. 10. A composition comprising the fragment of claim 1, claim 2 or claim 3, the polypeptide of claim 5, the protein of claim 6 or claim 8, the antibody of claim 7, and/or the nucleic acid of claim 9, wherein the composition is a vaccine, a diagnostic reagent, or an immunogenic composition. 11. The composition of claim 10 for use as a medicament 12. The use of the fragment of claim 1, claim 2 or claim 3, the polypeptide of claim 5, the protein of claim 8, the antibody of claim 7, and/or the nucleic acid of claim 9, in the manufacture of (i) a medicament for treating or preventing infection due to Neisserial bacteria (ii) a diagnostic reagent for detecting the presence of Neisserial bacteria or of antibodies raised against Neisserial bacteria and/or (iii) a reagent which can raise antibodies against Neisserial bacteria. 13. A method of treating a patient, comprising administering to the patient a therapeutically effective amount of a composition according to claim 10.

Inventors: GALEOTTI CESIRA, GRANDI GUIDO, MASIGNANI VEGA, MORA MARIAROSA, PIZZA MARIAGRAZIA, RAPPUOLI RINO, RATTI GUILIO, SCARLATO VINCENZO, SCARSELLI MARIA, GALEOTTI, CESIRA, GRANDI, GUIDO, MASIGNANI, VEGA, MORA, MARIAROSA, PIZZA, MARIAGRAZIA, RAPPUOLI, RINO, RATTI, GUILIO, SCARLATO, VINCENZO, SCARSELLI, MARIA
Applicants: CHIRON SPA, GALEOTTI CESIRA, GRANDI GUIDO, MASIGNANI VEGA, MORA MARIAROSA, PIZZA MARIAGRAZIA, RAPPUOLI RINO, RATTI GUILIO, SCARLATO VINCENZO, SCARSELLI MARIA, GALEOTTI, CESIRA, GRANDI, GUIDO, MASIGNANI, VEGA, MORA, MARIAROSA, PIZZA, MARIAGRAZIA, RAPPUOLI, RINO, RATTI, GUILIO, SCARLATO, VINCENZO, SCARSELLI, MARIA
Application year: 2000
Main classification: C12N15
IPC codes: A61K39, A61K48, C07K14, C07K16, C12N15, G01N33