TREATMENT OF SEXUAL DYSFUNCTION USING BOMBESIN ANTAGONIST

Abstract: Bombesin receptor antagonists have been found to be useful in the treatment of sexual dysfunction in both males and females.

Description: TREATMENT OF SEXUAL DYSFUNCTION USING BOMBESIN ANTAGONIST FIELD OF THE INVENTION The present invention relates to methods for the treatment of sexual dysfunction and to the preparation of medicaments for the treatment of sexual dysfunction. BACKGROUND TO THE INVENTION Both males and females can suffer from sexual dysfunction. Sexual dysfunctions are relatively common in the general population (see O'Donohue W, et al, Clin. Psychol Rev. 1997; 17: 537-566). The disorder may relate to seeking sexual behaviour (proceptivity) and/or to acceptance of sexual behaviour, accompanied by sexual arousal (receptivity). The prevalence of sexual problems is higher in populations receiving medicaments, in particular antidepressants and antihypertensives. A need for pharmacotherapy for sexual dysfunction is increasing, but there has been very little research effort directed at finding drugs to treat sexual dysfunction. Sexual dysfunctions include erectile dysfunctions of organic and psychogenic origin (Benet A.E and Melman A, 1995, Urol. Clin. N. Amer. 22: 699-709) as well as hypoactive sexual desire disorders, sexual arousal disorders, anorgasmy and sexual pain disorders (Berman et al., 1999, Urology 54: 385-391). In males, impotence can be defined as an inability to achieve penile erection or ejaculation. Its prevalence is claimed to be between 2% and 7% of the human male population, increasing with age up to 50 years and between 18% and 80% between 55 and 80 years of age. In the USA alone, for example, it has been estimated that there are up to 10 million impotent males, with the majority suffering from problems of organic rather than of psychogenic origin. Although many different drags have been shown to induce penile erection, they were only effective after direct injection into the penis e.g. intraurethrally or intracavernosally (i.e.) and were not approved for erectile dysfunction. US-A-5576290 discloses peptides which are stated to induce erection, but they have to be given subcutaneously e.g. by injection, and if an excessive dose is given they produce an exaggerated erectile response and stomach discomfort. Impotence treatment was revolutionized by the unexpected discovery that cGMP PDE inhibitors, e.g. pyrazolo[4,3-d]pyrimidin-7-ones were useful in the treatment of erectile dysfunction and could be administered orally, therefore obviating the disadvantages associated with i.e. administration. One such compound that is currently being manufactured is sildenafil (Viagra). Thirty to 50% of American women complain of sexual dysfunction. Ageing, menopause, and decline in circulating oestrogen levels significantly increase the incidence of sexual complaints. In a recent publication, Berman J.R. et al. (Int. J. Impot. Res., 1999, 11: S31-38), describe methodology for evaluating physiologic and subjective components of the female sexual response in the clinical setting and determine the effects of age and oestrogen status on them. Low or absent sexual drive/desire constitutes the commonest problem in the female population (Laumann et al., 1999 JAMA 281:537-544), but no therapy is available other than psychotherapy or empirical approaches. In a further publication (Bonney R.C et al., Scrip's Complete Guide to Women's Healthcare, PJB Publications Ltd, London, 2000) the causes and management of female sexual dysfunction are discussed, including the use of tibolone (Livial; Organon) which is a synthetic steroid that mimics the effects of oestrogen and has been reported to have mild androgenic properties, and the use of testosterone. So far in the UK and the USA no drug has been licensed by the Department of Health specifically for the treatment of female sexual dysfunction, hence there is an unmet medical need in the treatment of female sexual dysfunction, especially sexual drive problems. SUMMARY OF THE INVENTION This invention is based on the realisation that substances that act as bombesin receptor antagonists have utility in the treatment of sexual dysfunction, including the behavioural component thereof, in both male and female subjects. In other words, they can provide a treatment for erectile dysfunctions of organic and psychogenic origin as well as hypoactive sexual desire disorders, sexual arousal disorders, anorgasmy and sexual pain disorders. The invention therefore provides a method of treating sexual dysfunction which comprises administering to a subject suffering therefrom and in need of treatment an effective amount of a bombesin receptor antagonist. The invention further provides the use of a bombesin receptor antagonist in the manufacture of a medicament for preventing or treating male sexual dysfunction or female sexual dysfunction. Furthermore, many of the compounds of this invention have both the property of binding to bombesin receptors and the property that an effective dose can be administered orally. BRIEF DESCRIPTION OF FIGURES Figure 1: Effect of (S) 3-(lH-Indol-3-yl)-N-[l-(5-methoxy-pyridin-2-yl)-cyclohexyl- methyl]-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide (Compound (1)) on female rat sexual proceptivity. Figure 2: Effect of Compound (1) on female rat sexual receptivity. Figure 3: Effect of repeated administration of Compound (1) on female rat proceptivity. Figure 4: Effect of intracerebro entricular administration of Compound (i) on female rat sexual proceptivity. Figure 5: Inhibitory effect of NMB on female rat sexual proceptivity and antagonism of this effect by Compound (1) . Figure 6: Results of an investigation to show whether the effect of Compound (1) on female sexual behaviour is mediated through progesterone. Figure 7: Results of an investigation to show whether the effect of Compound (1) on female sexual behaviour is mediated through oestradiol. Figure 8: Results of an investigation to show whether the effect of Compound (1) on female sexual behaviour is mediated through prolactin. Figure 9: Results of an investigation to show whether the effect of Compound (1) on female sexual behaviour is mediated through LH. Figure 10: Results of an investigation to show whether the effect of Compound (T) on female sexual behaviour is mediated through FSH. Figure 11 : Effect of Compound (1) on the sexual behaviour of normal male rats (Mount Latency). Figure 12: Effect of Compound (1) on the sexual behaviour of normal male rats (Intromission Latency). Figure 13: Effect of Compound (1) on the sexual behaviour of normal male rats (Number of Mounts + Intromission). Figure 14: Effect of Compound (1) on the sexual behaviour of normal male rats (Ejaculation Latency). Figure 15: Effect of Compound (1) on the sexual behaviour of normal male rats (Refractory Period). Figure 16: Effect of Compound (1) on the sexual behaviour of sexually dysfunctional male rats (Mount Latency). Figure 17: Effect of Compound (1) on the sexual behaviour of sexually dysfunctional male rats (Ejaculation Latency). Figure 18: Effect of Compound (I) on the sexual behaviour of sexually dysfunctional male rats (% animals ejaculating). Figure 19: Effect of (S)-3-(lH-Indol-3-yl)-N-[l-(5-methoxy-pyridin-2-yl)- cyclohexyhnethyl] -2-methyl-2- [4-(4-nitro-phenyl)-oxazol-2-ylamino] -propionamide (Compound (2)) in PEG 200 on female rat sexual proceptivity. Figure 20: Effect of Compound (2) in methylcellulose on female rat sexual proceptivity. Figure 21: Effect of Compound (2) in PEG 200 on female rat sexual receptivity. DESCRIPTION OF PREFERRED EMBODIMENTS Bombesin receptors are present in hypothalamic areas. We have found that they can exert a neuromodulatory effect on sexual behaviour. Female sexual dysfunction can be grouped into four classes (Scrip's Complete Guide to Women's Healthcare, p.194-205, 2000), which include hypoactive sexual desire disorders, sexual arousal disorders, orgasmic disorders or anorgasmy and sexual pain disorders. Hypoactive sexual desire disorders can be characterised as persistent or recurrent lack of sexual thoughts/fantasies and lack of receptivity to sexual activity, causing personal distress. Common problems include sexual aversion disorders. Sexual arousal disorders can be characterised as persistent or recurrent inabihty to achieve or maintain adequate sexual excitement, causing personal distress. Common problems include lack of or diminished vaginal lubrication, decreased chtoral and labial sensation, decreased chtoral and labial engorgement and lack of vaginal smooth muscle relaxation. Orgasmic disorders can be characterised as persistent or recurrent difficulty or delay in attaining orgasm after adequate sexual stimulation and arousal, causing personal distress. Sexual pain disorders can be characterised by dyspareunia, (characterised by recurrent or persistent genital pain associated with sexual intercourse), vaginismus (characterised by recurrent or persistent involuntary spasm of the muscles of the outer third of the vagina which interferes with vaginal penetration, causing personal distress) and other pain disorders (characterised by recurrent or persistent genital pain induced by non coital sexual stimulation). The compounds of this invention are useful in the treatment of female sexual dysfunction, and this includes female sexual dysfunction associated with hypoactive sexual desire disorders, sexual arousal disorders, orgasmic disorders or anorgasmy, or sexual pain disorders. The psychogenic component of male sexual dysfunction has been classified by the nomenclature committee of the International Society for Impotence Research (and is illustrated in Sachs B. D., Neuroscience and Biobehavioral Review , 2000, 24 541-560) as generalised type, characterised by a general unresponsiveness or primary lack of sexual arousal, and ageing-related dechne in sexual arousability, characterised by generalised inhibition or chronic disorders of sexual intimacy. The inventors beheve that there are common mechanisms underlying the pathologies of male and female psychogenic sexual dysfunctions. The compounds of this invention are useful in the treatment of male sexual dysfunction, especially drug-induced male sexual dysfunction and psychogenic male sexual dysfunction associated with generalised unresponsiveness and ageing-related dechne in sexual arousability. We have tested compounds that are bombesin receptor antagonists using animal models that we have refined and believe are reliable and predictive, in particular with the capacity to make predictions for females. In rodents proceptive behaviour is under hormonal control, progesterone being essential for induction of proceptive behaviour in combination with oestrogen (Johnson M and Everitt B., Essential Reproduction (3 rd edn), Blackwell, Oxford, 1988). The evidence for the hormonal control of proceptive behaviour in primates is conflicting, but on the whole oestrogens and/or androgens appear to enhance proceptive behaviour (Baum M.J., J. Biosci., 1983; 33:578-582). The behavioural manifestations of proceptive behaviour in the rat include "hopping and darting" movement, with rapid vibration of the ears. Tests to assess the eagerness to seek sexual contact (sexual motivation) have been reported as the most appropriate way to measure proceptivity (Meyerson BJ, Lindstrom L.H., Acta Physiol. Scand., 1973; 389 (Suppl.): 1-80). Receptivity, in the rat, is demonstrated when the female assumes a lordotic position. This occurs when, on mounting, the male exerts pressure with his forepaws on the flanks of the receptive female. The main sites of neuronal control for this behaviour are the ventromedial nucleus (NMN) and the midbrain central grey area (MCG) (for review, see Wilson C.A., In: Sexual Pharmacology, Riley A.J. et al, (Eds), Clarendon Press, Oxford, 1993: 1-58). Bombesin is a 14-amino acid peptide originally isolated from the skin of the European frog Bombina bombina (Anastasi A. et al., Experientia, 1971; 27: 166). It belongs to a class of peptides which share structural homology in their C-terminal decapeptide region (DuttaA.S., Small Peptides; Chemistry, Biology, and Clinical Studies, Chapter 2, pp 66-82). At present, two mammalian bombesin-like peptides have been identified, the decapeptide neuromedin B (NMB) and a 23-residue amino acid, gastrin-releasing peptide (GRP). Bombesin evokes a number of central effects through actions at a heterogeneous population of receptors. The BBi receptor binds neuromedin B (NMB) with higher affinity than gastrin-related peptide (GRP) and neuromedin C (NMC) and BB 2 receptors bind GRP and NMC with greater affinity than NMB. More recently evidence has emerged of two more receptor subtypes denoted BB 3 and BB 4 but due to limited pharmacology, little is known of their function at present. BBi and BB 2 receptors have a heterogeneous distribution within the central nervous system indicating that the endogenous ligands for these receptors may differentially modulate neurotransmission. Among other areas, BB t receptors are present in the ventromedial hypothalamus (Ladenheim E.E et al, Brain Res., 1990; 537: 233-240). Bombesin-like immunoreactivity and mRNA have been detected in mammalian brain (BraunM., et al., Life. Sci., 1978; 23: 2721) (Battey J., et al., EBVS, 1991;14:524). NMB and GRP are believed to mediate a variety of biological actions (for a review, see WO 98/07718). The following patent applications disclose compounds capable of antagonising the effects of NMB and/or GRP at bombesin receptors: CA 2030212, ΕP 0309297, ΕP 0315367, ΕP 0339193, ΕP 0345990, ΕP 0402852, ΕP 0428700, ΕP 0438519, ΕP 0468497, ΕP 0559756, ΕP 0737691, ΕP 0835662, JP 07258081, UK 2231051, US 4943561, US 5019647, US 5028692, US 5047502, US 5068222, US 5084555, US 5162497, US 5244883, US 5439884, US 5620955, US 5620959, US 5650395, US 5723578, US 5750646, US 5767236, US 5877277, US 5985834, WO 88/07551, WO 89/02897, WO 89/09232, WO 90/01037, WO 90/03980, WO 91/02746, WO 91/04040, WO 91/06563, WO 92/02545, WO 92/07830, WO 92/09626, WO 92/20363, WO 92/20707, WO 93/16105, WO 94/02018, WO 94/02163, WO 94/21674, WO 95/00542, WO 96/17617, WO 96/28214, WO 97/09347, WO 98/07718, WO 00/09115, WO 00/09116. We believe that compounds disclosed in these applications can be used in the prevention or treatment of male and/or female sexual dysfunction, which is an indication that is not disclosed or suggested by the aforesaid apphcations, or indeed in any previous scientific publication concerning bombesin receptors. Preferred compounds Bombesin receptor antagonists to which this invention is applicable include both non-peptide compounds and peptide compounds. Compounds that can be formulated into compositions for oral administration, especially human oral administration, without substantial loss of activity are preferred. Many non-peptide compounds having the desired properties fall into this category. A) Non-peptide bombesin receptor antagonists One preferred genus of compounds for use in the invention comprises bombesin receptor antagonists of the formula (I) and pharmaceutically acceptable salts thereof, wherein: • j is O or l; • k is O or l; • 1 is 0, 1, 2, or 3; • m is O or l; • n is 0, 1 or 2; • Ar is phenyl, pyridyl or pyrimidyl, each unsubstituted or substituted by from 1 to 3 substituents selected from alkyl, halogen, alkoxy, acetyl, nitro, amino, - CH 2 NR 10 R n , cyano, -CF 3 , -NHCONH , and -CO 2 R 12 ; • R*is hydrogen or straight, branched, or cyclic alkyl of from 1 to 7 carbon atoms; • R is hydrogen or forms a ring with Rl of from 3 to 7 carbon atoms; R 2 is hydrogen or straight, branched, or cyclic alkyl of from 1 to 8 carbon atoms which can also contain 1 to 2 oxygen or nitrogen atoms; R9 is hydrogen or forms with R 2 a ring of from 3 to 7 carbon atoms which can contain an oxygen or nitrogen atom; or R 2 and R^ can together be a carbonyl; Arl can be independently selected from Ar and can also include pyridyl-N- oxide, indolyl, imidazolyl, and pyridyl; R4, R5, R6 S and are each independently selected from hydrogen and lower alkyl; R 4 can also form with R^ a covalent link of 2 to 3 atoms which may include an oxygen or a nitrogen atom; R3 can be independently selected from Ar or is hydrogen, hydroxy, -NMβ2, N-methyl-pyrrolyl, imidazolyl, N-methyl-imidazolyl, tetrazolyl, N-methyl- tetrazolyl, thiazolyl, -CONR 13 R 14 , alkoxy, wherein p is 0, 1 or 2 and Ar 2 is phenyl or pyridyl; Rl , RU, R!2, Rl3 and R*4 are each independently selected from hydrogen or straight, branched, or cyclic alkyl of from 1 to 7 carbon atoms. Preferred compounds are those of Formula (la) wherein Ar is phenyl unsubstituted or substituted with 1 or 2 substituents selected from isopropyl, halo, nitro, and cyano; 4, R5, and are hydrogen; R is methyl or hydrogen; R3 is 2-pyridyl or hydroxy; and Arl is indolyl, pyridyl, pyridyl-N-oxide, or imidazolyl. Other preferred compounds are those of Formula I wherein Ar is unsubstituted phenyl; R! is cyclopentyl or tert-butyl; R4 and R are hydrogen; R is methyl; R6 is hydrogen; R3 is phenyl with two isopropyl substituents, unsubstituted phenyl, or Arl is indolyl. Other preferred compounds are those of Formula I wherein Ar is 2,6-diisoρropyl-phenyl, 4-nitro-phenyl, and 4-cyano-phenyl; R4, R5, and R6 are hydrogen; • R is methyl; • R 2 is hydrogen or cyclohexyl; and • R3 is hydroxyl, pyridyl, At present, most preferred of the compounds of formula (I) is (S) 3-(lH-rndol- 3-yl)-N-[l-(5-methoxy-pyridin-2-yl)-cyclohexyhnethyl]-2-methyl-2-[3-(4-nitro- phenyl)-ureido] -propionamide (also referred to as Compound 1) and its pharmaceutically acceptable salts. Other preferred compounds of Formula (I) are set out below and included also are their pharmaceutically acceptable salts: (S)N-cyclohexylmethyl-2-[3-(2,6-dusopropyl-phenyl)-ureido]-3-(lH-indol-3-yl)- 2-methyl-propionamide; N-cyclohexylmethyl-2-[3-(2,6-diisopropyl-phenyl)-ureido]-3-(lH-indol-3-yl)- N-methyl-propionamide; N-cyclohexylmethyl-2-[3-(2,6-diisopropyl-phenyl)-l-methyl-ureido]-3-(lH- indol-3-yl)-propionamide; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-2-methyl-3-(l -oxy-pyridfn-2-yl)-N-(l - pyridin-2-yl-cyclohexylmethyl)-propionamide; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-2-methyl-3-pyridin-2-yl-N-(l-pyridin-2- yl-cyclohexylmethyl)-ρropionamide; 2-[3-(2-tert-butyl-phenyl)-ureido]-N-cyclohexyhnethyl-3-(lH-indol-3-yl)-2- methyl-propionamide; N-cyclohexylmethyl-2-[3-(2,6-dichloro-phenyl)ureido]-3-(lH-indol-3-yl)-2- methyl-propionamide; N-cyclohexylmethyl-2-[3-(2,6-dimethoxy-ρhenyl)ureido]-3-(lH-indol-3-yl)-2- methyl-propionamide; N-cyclohexylmethyl-2-[3-(2,6-dimethylamino-phenyl)-ureido]-3-(lHindol-3- yl)-2-methyl-propionamide; (S) N-cyclohexylmethyl-3-(lH-indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)- ureido]-propionamide; N-cyclohexylmethyl-2-[3-(2,2-dimethyl- 1 -phenyl)propyl)-ureido]-3-(lH- indol-3-yl)-2-methyl-propionamide; [S-(R*, R*)] 3-(lH-indol-3-yl)-2-methyl-2-{3-[l-(4-nitro-phenyl)-ethyl]- ureido}-N-(l-pyridin-2-yl-cyclohexylmethyl)-propionamide; N-(2,2-dimethyl-4-phenyl-[l,3]dioxan-5-yl)-3-(lH-indol-3-yl)-2-methyl-2-[3- (l-phenyl-cyclopentylmethyl)ureido]-propionamide; (S)-N-(2,6-diisopropyl-phenyl)-2-[3-(2,2-dimethyl-l-phenyl-propyl)-ureido]- 3 -( lH-indol-3 -yl)-propionamide; (R)-N-(2,6-diisopropyl-phenyl)-2-[3 -(2,2-dimethyl- 1 -phenyl-propyl)-ureido] - 3-(lH-indol-3-yl)-propionamide; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-N-(2,2-dimethyl-4-phenyl-[l,3]dioxan- 5-yl)-3-(lH-indol-3-yl)-2-methyl-propionamide; N-cyclohexyl-2-[3-(2,6-diisopropyl-phenyl)-ureido]-3-(lH-indol-3-yl)-2- methyl-propionamide; N-(2-cyclohexyl-ethyl)-2-[3-(2,6-diisopropyl-phenyl)-ureido]-3-(lH-indol-3- yl)-2-methyl-propionamide; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl- propionamide; 2-[3-(2,6-diisoρropyl-phenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl-N-(3- methyl-butyl)-propionamide; 2-[3-(2,6-diisoρropyl-phenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl-N-(3- phenyl-propyl)-proρionamide; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl-N-(l,2,3,4- tetrahydro-naphthalen- 1 -yl)-propionamide; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl-N-(2- phenyl-cyclohexyl)-propionamide; 2-[3-(2,6-diisopropyl-ρhenyl)-ureido]-N-indan-l-yl-3-(lH-indol-3-yl)-2- methyl-propionamide; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-N-(l-hydroxy-cyclohexyhnethyl)-3-(lH- indol-3-yl)-2-methyl-proρionamide; 2-[3-(2,6-diisopropyl-ρhenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; 2-[3-(2,6-diisoρropyl-ρhenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl-N-(6,7,8,9- tetrahydro-5H-benzocyclohepten-5-yl)-proρionamide; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl-N-ρhenyl- propionamide; N-(l-hydroxy-cyclohexylmethyl)-3-(lH-indol-3-yl)-2-methyl-2-[3-(4-nitro- phenyl)-ureido] -propionamide; 2-[3-(4-cyano-ρhenyl)-ureido]-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl- cyclohexylmethyl)-propionamide; (S) 3-(lH-indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-N-(l-pyridin-2- yl-cyclohexylmethyl)-propionamide; (S) 3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-2-[3-(4- trifluoromethyl-phenyl)-ureido]-propionamide; (S) 4-(3-{2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -ureido)-benzoic acid ethyl ester; 2-[3-(2,6-diisopropyl-phenyl)-ureido]-3-(lH-imidazol-4-yl)-N-(l-pyridin-2-yl- cyclohexylmethyl)-proρionamide; 2-[3-(2,6-diisopropyl-ρhenyl)-ureido]-2-methyl-N-(l-pyridin-2-yl- cyclohexyhnethyl)-3-(2-trifluoromethyl-phenyl)-propionamide; 2- [3 -(2,6-diisopropyl-phenyl)-ureido] -2-methyl-3 -(2-nitro-phenyl)-N-( 1 - pyridin-2-yl-cyclohexylmethyl)-propionamide; (S) 3-(lH-indol-3-yl)-N-[l-(5-methoxy-ρyridin-2-yl)-cyclohexyhnethyl]-2- methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide; and N-cyclohexylmethyl-2-[3-(2,6-diisopropyl-phenyl)-ureido]-2-methyl-3- pyridin-2-yl-propionamide. Another preferred genus of compounds which can be used for the present purpose is of formula (IT) and includes pharmaceutically acceptable salts thereof: (Ar wherein: • j is 0, 1 or 2; • k is O or l; • 1 is 0, 1, 2, or 3; • m is O or l; • n is 0, 1 or 2; • q is O or l; • r is 0 or 1 ; when r is 0, Ar is replaced by hydrogen; • Ar is phenyl, pyridyl, pyrimidyl, thienyl, furyl, imidazolyl, pyrrolyl or thiazolyl each unsubstituted or substituted by from 1 to 3 substituents selected from acetyl, alkoxy, alkyl, amino, cyano, halo, hydroxy, nitro, sulfonamido, sulfonyl, -CF 3 , -OCF 3 , -CO 2 H, -CH 2 CN, -SO 2 CF 3 , -CH 2 CO 2 H and - (CH 2 ) S NRR wherein s is 0, 1, 2 or 3 and R 7 and R 8 are each independently selected from H, straight or branched alkyl of up to 6 carbon atoms, or R and R 8 together with the nitrogen atom to which they are linked can form a 5- to 7- membered aliphatic ring which may contain 1 or 2 oxygen atoms; • R is hydrogen, straight or branched alkyl of up to 6 carbon atoms or cycloalkyl of between 5 and 7 carbon atoms which may contain 1 or 2 nitrogen or oxygen atoms; • R is hydrogen, methyl, or forms with R an aliphatic ring of from 3 to 7 atoms which can contain an oxygen or nitrogen atom, or together with R 1 is a carbonyl group; • Ar is independently selected from Ar or is indolyl or pyridyl-N-oxide; 3 4 5 R , R , and R are each independently selected from hydrogen and lower alkyl; 2 R is independently selected from Ar or is hydrogen, hydroxy, alkoxy, 9 10 9 10 - Me2, -CONRR wherein R and R are each mdependently selected from hydrogen, straight or branched alkyl of up to 6 carbon atoms, or R 9 and R 10 together with the nitrogen atom to which they are linked can form a 5-to 7- membered aliphatic ring which may contain 1 or 2 oxygen or nitrogen atoms, or R 2 is wherein p is 0, 1 or 2 and Ar 2 is phenyl or pyridyl; X is a divalent radical derived from any of the following where the ring nitrogen atoms may have lower alkyl groups attached thereto, R 11 and R 12 are independently selected from H, halogen, hydroxy, alkoxy, acetyl, nitro, cyano, amino, CF 3 and -(CH 2 ) t NR 13 R 14 where t can be 0 or 1, R 13 and R 14 are each independently selected from hydrogen, straight or branched alkyl of up to 6 carbon atoms or cycloalkyl of 5 to 7 carbon atoms, containing up to 2 oxygen or nitrogen atoms. A preferred species of compounds within the genus defined by formula (II) is represented by the formula (Ha), and includes pharmaceutically acceptable salt thereof: Ar - wherein: • n is O or l; • Ar is phenyl or pyridyl which may be unsubstituted or substituted with from 1 to 3 substituents selected from halogen, alkoxy, nitro and cyano; • Ar 1 is independently selected from Ar or is pyridyl-N-oxide or indolyl; • R 6 forms with R 1 an aliphatic ring of from 3 to 7 atoms which can contain an oxygen or nitrogen atom, or together with R 1 is a carbonyl group; • R 2 is independently selected from Ar or is hydrogen, hydroxy, alkoxy, 9 10 9 10 dimethylamino, tetrazolyl or -COΝRR wherem R and R are each independently selected from hydrogen or methyl or R 2 is any of wherein p is 0, 1 or 2 and Ar 2 is phenyl or pyridyl; • R 3 , R 4 and R 5 are each independently selected from hydrogen and methyl; and • X is selected from: Q 0 "Q O ? O R 11 and R 12 being independently selected from H, halogen, hydroxy, alkoxy, acetyl, nitro, cyano, amino, CF 3 and (CH 2 ) t NR 13 R 14 wherein t is 0 or 1 and R 13 and R 14 are independently selected from hydrogen and methyl. A sub-species of preferred compounds within the general formula (II) has the formula (lib) or (He): wherein Ar and R 2 independently represent phenyl or pyridyl which may be unsubstituted or substituted with from 1 to 3 substituents selected from halogen, alkoxy, nitro and cyano, and pharmaceutically acceptable salts thereof. A particularly preferred compound falling within formula (II) is (S)-3-(lH- indol-3 -yl)-N-[ 1 -(5 -methoxy-pyridin-2-yl)-cyclohexylmethyl] -2-methyl-2- [4-(4-nitro- phenyl)-oxazol-2-ylamino]-propionamide (also referred to as Compound 2) and its pharmaceutically acceptable salts. Other preferred compounds falling within formula (II) are set out below and included also are their pharmaceutically acceptable salts: (S)-3-(lH-indol-3-yl)-N-(l-methoxymethyl-cyclohexylmethyl)-2-methyl-2-[4- (4-nifro-phenyl)-oxazol-2-ylamino]-ρropionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-[4-(4-nitro-phenyl)-oxazol-2-ylamino]-N-(2- oxo-2-phenyl-ethyl)-propionamide; (S)-N-[l-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl-2-[4-(4-nitro- phenyl)-oxazol-2-ylamino]-3-phenyl-propionamide; (S)-2-[4-(4-cyano-ρhenyl)-oxazol-2-yl.ιmino]-3-(lH-indol-3-yl)-N-[l-(5- methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl-propionamide; (S)-3-(lH-indol-3-yl)-N-[l-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]-2- methyl- 2-(4-phenyl-oxazol-2-ylamino)-propionamide; (S)-2-(4-ethyl-oxazol-2-ylarrιino)-3-(lH-indol-3-yl)-N-[l-(5-methoxy-pyridin- 2-yl)-cyclohexylmethyl]-2-methyl-propionamide; (S)-3-(lH-indol-3-yl)-N-[l-(5-methoxy-ρyridin-2-yl)-cyclohexylmethyl]-2- methyl-2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-propionamide; (S)-2-(benzooxazol-2-ylannno)-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl- cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(pyridin-4-ylamino)-N-(l-pyridin-2-yl- cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-(isoquinol-4-ylamino)-2-methyl-N-(l-ρyridin-2-yl- cyclohexylmethyl)-propionamide; (S)-3-(lH-mdol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-2- (pyrimidin-5-ylamino)-propionamide; (S)-2-(biρhenyl-2-ylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl- cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-2-m- tolylamino-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(6-ρhenyl-pyridin-2-ylamino)-N-(l-ρyridin- 2-yl-cyclohexylmethyl)-propionamide; (R)-3-phenyl-2-phenylamino-N-(l-pyridin-2-yl-cyclohexylmethyl)- propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-phenylethylamino-N-(l-pyridin-2-yl- cyclohexylmethyl)-propionamide; (S)-2-[(benzofVnan-2-ylmethyl)-aπιino]-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridm-2-yl-cyclohexylmethyl)-propionamide, and (S)-3-(lH-indol-3-yl)-2-methyl-2-(4-mtio-benzylamino)-N-(l-pyridin-2-yl- cyclohexylmethyl)-propionamide. A third genus of bombesin receptor antagonists according to the invention has the formula (III) and include pharmaceutically acceptable salts thereof: R 3 R 5 R 4 R 1 wherein: • k is 0, 1 or 2; • 1 is 0, 1, 2 or 3; • m is O or l; • n is 0, 1 or 2; • X is -CO-, -OCO, -SO- and -SO 2 -; • Ar is benzimidazolyl, benzofuryl, benzothiadiazolyl, benzothiazolyl, benzothienyl, benzopyrazinyl, benzotriazolyl, benzoxadiazolyl, furyl, imidazolyl, indanyl, indolyl, isoquinolyl, isoxazolyl, naphthyl, oxazolyl, phenyl, pyrazinyl, pyrazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrrolyl, quinolinyl, tetralinyl, tetrazolyl, thiazolyl, thienyl or triazolyl each unsubstituted or substituted with from 1 to 3 substituents selected from amino, acetyl, alkyl (straight chain or branched with from 1 to 6 carbon atoms), alkoxy, cyano, halogen, hydroxy, nitro, phenyl, pyridyl, pyrrolyl, isoxazolyl, phenoxy, tolyloxy, - CF 3 , -OCF 3 , -SO 2 CF 3 , -ΝΗCOΝΗ 2 , -CO 2 H, -CH 2 CO 2 H, -CH 2 CN, SO 2 Me, SO 2 NH 2 , SO 2 Ph, -(CH 2 ) q NR 7 R 8 , -CONR 9 R 10 , and CO 2 R n , wherein q is 0, 1 or 2 and R 7 , R 8 , R 9 , R 10 , R u are each independently selected from hydrogen or straight or branched alkyl of up to 6 carbon atoms or cyclic alkyl of between 5 to 7 atoms which may contain 1 or 2 oxygen or nitrogen atoms or R 7 and R 8 or R 9 and R 10 together with the nitrogen atom to which they are linked can form a 5- to 7-membered aliphatic ring which may contain 1 or 2 oxygen or nitrogen atoms; Ar 1 is independently selected from Ar and can also be pyridyl-N-oxide; R 1 is hydrogen or straight or branched alkyl of up to 6 carbon atoms or cyclic alkyl of between 5 and 7 atoms which may contain 1 or 2 oxygen or nitrogen atoms; R 2 is independently selected from Ar or is hydrogen, hydroxy, alkoxy, -ΝMe 2 , -CONR 12 R 13 , wherein p is 0, 1 or 2, Ar 2 is phenyl or pyridyl; and, R* 2 and Rl3 are each independently selected from hydrogen, straight or branched alkyl of up to 6 carbon atoms or cyclic alkyl of between 5 and 7 carbon atoms; R 3 , R 4 and R 5 are each independently selected from hydrogen and lower alkyl; and R 6 is hydrogen, methyl or forms with R 1 a ring of from 3 to 7 carbon atoms which can contain an oxygen or nitrogen atom, or R 1 and R 6 can together be carbonyl. preferred group of the compounds of formula (III): • k is O or l; • 1 is 1; • m is O or l; • n is O or l; • X is -C(O)-, -OC(O)-, or -SO 2 -; • Ar is benzofiiryl, furyl, indolyl, isoquinolyl, naphthyl, phenyl, pyridyl, quinolyl or thienyl each unsubstituted or substituted with 1 or 2 substituents selected from alkoxy, cyano, halogen, nitro, phenyl, phenoxy, -CF 3 , 7 R 7 R -(CH 2 ) q NR R , wherein R and R can form a ring of between 5 to 7 atoms 7 R which may contain 1 or 2 oxygen or nitrogen atoms, or R and R can be independently selected from hydrogen, straight or branched alkyl of up to 4 carbon atoms or cyclic alkyl of 5 carbon atoms; • Ar 1 is independently selected from Ar, preferably indolyl, and can also be pyridyl-N-oxide; • R 1 and R 6 can form a cyclic alkyl of from 5 to 7 carbon atoms or R 1 and R 6 together are carbonyl; • R 2 is independently selected from unsubstituted or substituted pyridyl or is hydrogen, hydroxy, alkoxy, -NMe 2 , -CONR 12 R 13 wherein R 12 andR 13 are each independently selected from H and CH 3 ; • R 3 , R 4 and R 5 are each independently selected from hydrogen and methyl. In another preferred group of the compounds of Formula (III), • l is l; • m is l; • n is 0; • R 2 is 2-pyridyl; • R 6 forms a cyclohexyl with R 1 . A particularly preferred group of compounds is of formula (Ilia): wherein Ar, k and X have the meanings given above in first, and the pyridine ring is optionally substituted by with 1 or 2 substituents, R and R', independently selected from alkoxy, cyano, halogen, nitro, phenyl, phenoxy, - CF 3 , -(CH 2 ) q NR 7 R 8 , wherein R 7 and R 8 together with the nitrogen atom to which they are linked can form a 5- to 7-membered aliphatic ring which may contain 1 or 2 oxygen or nitrogen atoms, or R 7 and R 8 can be independently selected from hydrogen or cyclic alkyl of between 5 to 7 carbon atoms, and their pharmaceutically acceptable salts thereof. In a further set of compound (HIa), Ar is benzofuryl, furyl, indolyl, isoquinolyl, naphthyl, phenyl, pyridyl, quinolyl or thienyl each unsubstituted or substituted with 1 or 2 substituents selected from alkoxy, cyano, halogen, nitro, phenyl, phenoxy, -CF 3 , -(CH 2 ) q NR 7 R 8 , wherein R 7 and R 8 can form a ring of between 5 to 7 atoms which may contain 1 or 2 oxygen or nitrogen atoms, or R 7 or R 8 can be a independently selected from hydrogen or cyclic alkyl of 5 carbon atoms, and X is -C(O)-, -OC(O)- or -SO 2 . Preferred N-terminal amide derivatives of the compounds of formula HII) Amongst N-terminal amide derivatives, i.e. compounds of formula (UI) wherein X is -C(O)-, the following compounds are most preferred: N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl} -4-mfro-benzamide; C-dimethylamino-N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl- cyclohexyhnethyl)-carbamoyl] -ethyl} -benzamide; lH-indole-2-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2- yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; benzo[b]thiophene-2-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l- pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; lH-indole-5-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2- yl-cyclohexylmethyl)-carbamoyl]-ethyl} -amide; and lH-indole-2-carboxylic acid ((S)-2-(lH-indol-3-yl)-l-{[l-(5-methoxy-pyridin- 2-yl)-cyclohexylmethyl]-carbamoyl} - 1 -methyl-ethyl)-amide. Other preferred N-terminal amide derivatives of formula (DI) include the following: N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl} -benzamide; N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- c-ιrbamoyl]-ethyl}-4-methyl-benzamide; 4-chloro-N-{(S)-2-(lH-indol-3-yl)-l-ήiethyl-l-[(l-pyridin-2-yl- cyclohexylmethyl)-carbamoyι] -ethyl} -benzamide; N-{(S)-2-(lH ndol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl] -ethyl} -4-methoxy-benzamide; N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexylmethyl)- carbamoyl] -ethyl} -4-methanesulfonyl-benzamide; 3-cyano-N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl- cyclohexylmethyl)-carbamoyl]-ethyl}-benzamide; 3-chloro-N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl- cyclohexylmemyl)-carbamoyl]-ethyl}-berιzamide; N- {(S)-2-(lH-indol-3-yl)- 1 -methyl- 1 -[(1 -pyridin-2-yl-cyclohexylmethyl)- carbamoylj-ethyl} -3-methoxy-benzamide; N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl}-3-methanesulfonyl-benzamide; dimethylamino-N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl- cyclohexylmethyl)-carbamoyl]-ethyl}-benzamide; N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl}-3-methyl-benzamide; 2-chloro-N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl- cyclohexylmethyl)-carbamoyl] -ethyl} -benzamide; N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -2-nitro-benzamide; N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -2-methoxy-benzamide; N- {(S)-2-(lH-indol-3-yl)- 1 -methyl-1 -[(1 -pyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl}-2-methyl-benzamide; 2-fluoro-N- {(S)-2-(lH-indol-3-yl)- 1-methyl- 1 -[(l-pyridin-2-yl- cyclohexylmethyl)-carbamoyl] -ethyl} -benzamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-2-(2-p- tolyl-ethanoylamino)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexyhnethyl)-2-(2-o- tolyl-ethanoylamino)-propionamide; (S)-2-[2-(4-hydroxy-phenyl)-ethanoyIamino]-3-(lH-indol-3-yl)-2-methyl-N- (1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-[2-(3-hydroxy-phenyl)-ethanoylamino]-3-(lH-indol-3-yl)-2-methyl-N- (l-pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexyhnethyl)-2-(2-m- tolyl-ethanoylamino)-propionamide; (S)-2-[2-(2-fluoro-ρhenyl)-ethanoylamino]-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridm-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-2-(2- thiophen-3-yl-ethanoylamino)-propionamide; N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl] -ethyl} -isonicotinamide; furan-3 -carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl- cyclohexylmethyl)-carbamoyl]-ethyl}-amide; furan-2-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl- cyclohexylmethyl)-carbamoyl]-ethyl}-amide; 5-methyl-isoxazole-3-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l- pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; 1 -methyl- 1 H-pyrrole-2-carboxylic acid {(S)-2-( lH-indol-3 -yl)- 1 -methyl- 1 - [(1 -pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-ethyl} -amide; thiophene-2-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2- yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; thiophene-3-carboxylic acid {(S)-2-(lH-indol-3-yl)-l -methyl-l-[(l-pyridin-2- yl-cyclohexylmethyl)-carbamoyl] -ethyl} -amide; lH-indole-6-carboxylic acid {(S)-2-(lH-mdol-3-yl)-l-me yl-l-[(l-pyridin-2- yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; lH-indole-5-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2- yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; lH-indole-4-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2- yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; lH-indole-7-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2- yl-cyclohexylmethyl)-carbamoyl] -ethyl} -amide; l-methyl-lH-indole-2-carboxylic acid ' {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l- pyridin-2-yl-cyclohexylmethyl)-carbamoyl] -ethyl} -amide; benzothiazole-6-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l- ρyridm-2-yl-cyclohexylmethyl)-carbarnoyι] -ethyl} -amide; lH-benzotriazole-5-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l- pyridin-2-yl-cyclohexylmethyl)-carbamoyl] -ethyl} -amide; 3-methyl-thioρhene-2-carboxylic acid {(S)-2-(lH-mdol-3-yl)-l-methyl-l-[(l- pyridin-2-yl-cyclohexylmethyl)-carbamoyl] -ethyl} -amide; 5-methyl-thiophene-2-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l- pyridin-2-yl-cyclohexylmethyl)-carbamoyl] -ethyl} -amide; 6-methyl-pyridine-2-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l- pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; isoquinoline-3 -carboxylic acid {(S)-2-( lH-indol-3 -yl)- 1 -methyl- 1 -[( 1 -pyridin- 2-yl-cyclohexylmethyl)-carbamoyl] -ethyl} -amide; quinoxaline-2-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin- 2-yl-cyclohexyhnethyl)-carbamoyl]-ethyl}-amide; quinoline-8-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2- yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; 5-phenyl-oxazole-4-carboxylic acid {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l- pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide; (S)-3-(lH-indol-3-yl)-2-[2-(4-methoxy-phenyl)-ethanoylamino]-2-methyl-N- ( 1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-[2-(4-dimethylamino-phenyl)-ethanoylamino]-3-(lH-indol-3-yl)-2- methyl-N-(l -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-[2-(2-nitro-phenyl)-ethanoylamino]-N-(l- ρyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-[2-(2-methoxy-phenyl)-ethanoylamino]-2-methyl-N- (1 -pyridm-2-yl-cyclohexylme1hyl)-ρropionamide; and N-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl}-2-ρyrrol-l-yl-benzamide. Preferred N-terminal urethane derivatives of the compounds of formula (III) Amongst N-terminal urethane derivatives, i.e. compounds of formula DI wherein X is -OC(=O)- , the following compounds are particularly preferred: {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl}-carbamic acid naphthalen-1-ylmethyl ester; {(S)-2-(lH-indol-3-yl)- 1 -methyl-1 -[(1 -pyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -carbamic acid 3,4-dichloro-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl} -carbamic acid 3-nitro-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyTJ-ethyl} -carbamic acid 3-trifluoromethyl-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl} -carbamic acid quinolin-6-ylmethyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl} -carbamic acid 4-nitro-benzyl ester; and {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -carbamic acid 3-cyano-benzyl ester. Other preferred N-teπriinal urethane derivatives of formula (DT) include the following: {(S)-2-(lH-indol-3-yl)- 1 -methyl- 1-[(1 -ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl} -carbamic acid 3,4-dimethoxy-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -carbamic acid naphthalen-2-ylmethyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl} -carbamic acid indan-2-yl ester; {(S)-2-(lH-indol-3-yl)- 1 -methyl- 1 -[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl] -ethyl} -carbamic acid 4-methoxy-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl}-carbamic acid 4-chIoro-benzyI ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -carbamic acid 2-fluoro-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl} -carbamic acid 2-chloro-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -carbamic acid 4-nitro-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexylmethyl)- carbamoyl] -ethyl} -carbamic acid 2-methyl-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl}-carbamic acid 4-tert-butyl-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl} -carbamic acid 2-methoxy-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl} -carbamic acid 4-trifluoromethyl-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl} -carbamic acid 3-ethoxy-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl} -carbamic acid 3-cyano-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyI-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -carbamic acid 2,4-dichloro-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl} -carbamic acid 3-methyl-benzyl ester; {(S)-2-(lH-indol-3-yl)- 1 -methyl- 1 -[(1 -ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -carbamic acid 3-phenoxy-benzyl ester; {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexyhnethyl)- carbamoyl] -ethyl} -carbamic acid 4-methyl-benzyl ester; and {(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethyl} -carbamic acid 2,3-dichloro-benzyl ester. Preferred N-terminal sulfonamide derivatives of the compounds of formula (III) Amongst N-terminal sulfonamide derivatives of formula (ID) (compounds of formula (ID) wherein X is -SO 2 -) the following compounds are particularly preferred: (S)-3-(lH-indol-3-yl)-2-methyl-2-phenyhnethanesulfonylamino-N-(l-pyridin- 2-yl-cyclohexylmethyl)-ρropionamide; (S)-2-(2-clhoro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(naρhthalene-l-sulfonylamino)-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexyhnethyl)-2- (quinoline-8-sulfonylamino)-propionamide; , (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-2-(2- trifluoromethyl-benzenesulfonylammo)-proρionamide; (S)-2-(biphenyl-2-sulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2- yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(5-methyl-2-phenoxy-benzenesulfonyl- amino)-N-(l -pyridin-2-yl-cyclohexylmethyl)-proρionamide; and (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-2-(2- ?- tolyloxy-benzenesulfonylamino)-propionamide. Further preferred N-terminal sulfonamide derivatives of formula (ID) include the following: (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-2- (toluene-4-sulfonylamino)-propionamide; (S)-3-(lH-indol-3-yl)-2-methanesulfonylamino-2-methyl-N-(l-pyridin-2-yl- cyclohexylmethyl)-propionamide; (S)-2-(2-fluoro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(4-chloro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexyhnethyl)-2-(2,2,2- trifluoro-ethanesulfonylamino)-ρropionamide; (S)-2-(5-dimethylamino-naphthalene-l-sulfonylamino)-3-(lH-indol-3-yl)-2- methyl-N-( 1 -pyridin-2-yl-cyclohexyhnethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(naphthalene-2-sulfonylanhno)-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-mdol-3-yl)-2-methyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-2- (thiophene-2-sulfonylamino)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(3-nitro-benzenesulfonylamino)-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(4-fluoro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(4-nitio-berιzenesulfonylamino)-N-(l- ρyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-2-(3- trifluoromethyl-benzenesulfonylamino)-propionamide; (S)-2-(3,4-dichloro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(3-fluoro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-ρropionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexyhnethyl)-2-(4- trifluoromethyl-benzenesulfonyl-ιmino)-proρionamide; (S)-2-(5-chloro-thiophene-2-sulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propion-ιmide; (S)-2-(3-cmoro-benzenesulfonyl-ιmino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-2- (toluene-3-sulfonylamino)-propionamide; (S)-2-(3,4-dimethoxy-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N- (l-pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(4-cyano-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(2-cyano-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(5-chloro-l,3-dimethyl-lH-pyrazole-4-sulfonylamino)-3-(lH-indol-3- yl)-2-methyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(3,5-dimethyl soxazole-4-sulfonylamino)-3-(lH-indol-3-yl)-2-methyl- N-( 1 -pyridin-2-yl-cyclohexylmethyI)-propionamide; (S)-2-(benzo[l,2,5]t adiazole-4-sulfonylan ino)-3-(lH-indol-3-yl)-2-methyl- N-(l-pyridin-2-yl-cyclohexyhnethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(l-memyl-lH-imid-ιzole-4-sulfonylanύno)- N-( 1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(benzo[l,2,5]oxadiazole-4-sulfonylamino)-3-(lH-indol-3-yl)-2-methyl- N-(l-pyridin-2-yl-cyclohexylmethyl)-propionamide; 3-{(S)-2-(lH-indol-3-yl)-l-methyl-l-[(l-ρyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethylsulfamoyl}-thiophene-2-carboxylic acid methyl ester; (S)-3-(lH-indol-3-yl)-2-(5-isoxazol-3-yl-thiophene-2-sulfonylamino)-2- methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(2-nifro-phenylmethanesulfonyl-m ino)-N- ( 1 -pyridin-2-yl-cyclohexylmethyl)-ρropionamide; (S)-2-(3-cyano-benzenesulfonylanhno)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(l,2-dimethyl-lH-imidazole-4-sμlfonylamino)-3-(lH-indol-3-yl)-2- methyl-N-( 1 -pyridin-2-yl-cyclohexyhnethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-(3-methoxy-benzenesulfonylanύno)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(8-nitro-naρhthalene-l-sulfonylamino)-N- (1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(2-chloro-5-nifro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N- (l-ρyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-2-(2,4,6- 1n^hloro-benzenesulfonylamino)-propionamide; (S)-2-(4-chloro-2-nitro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N- ( 1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(5-benzenesulfonyl-thiophene-2-sulfonylamino)-3-(lH-indol-3-yl)-2- methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexyhnethyl)-2-(4- trifluoromethoxy-benzenesulfonylamino)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(5-methyl-2-phenoxy- benzenesulfonylammo)-N-(l-pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-2-(2-p- tolyloxy-benzenesulfonylamino)-propionamide; 2- {(S)-2-(lH-indol-3-yl)- 1 -methyl- 1 -[(1 -ρyridin-2-yl-cyclohexyhnethyl)- carbamoyl]-ethylsulfamoyl}-benzoic acid methyl ester; (S)-2-(3-chloro-4-fluoro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl- N-(l-pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(2,5-dichloro-tl ή ophene-3-sulfonylamino)-3-(lH-indol-3-yl)-2-methyl- N-( 1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(3-chloro-4-methyl-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl- N-(l-pyridin-2-yl-cyclohexylmethyl)-proρionamide; (S)-3-(lH-indol-3-yl)-2-(2-methoxy-4-methyl-benzenesulfonylamino)-2- methyl-N-( 1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-2-(5- pyridm-2-yl-tlύophene-2-sulfonylamino)-propionamide; (S)-2-(5-bromo-6-chloro-pyridine-3-sulfonylamino)-3-(lH-indol-3-yl)-2- methyl-N-( 1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(2,4-dimfro-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-(4-methanesulfonyl-benzenesulfonylamino)-2-methyl- N-(l-pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(4-tert-butyl-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(2,4-dichloro-5-methyl-benzenesulfonylamino)-3-(lH-indol-3-yl)-2- methyl-N-( 1 -pyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-2-(2-chloro-5-trifluoromethyl-benzenesulfonylamino)-3-(lH-indol-3-yl)- 2-me1hyl-N-(l-ρyridin-2-yl-cyclohexylmethyl)-propionamide; (S)-3-(lH-indol-3-yl)-2-methyl-2-(2-mfro-4-trifluoromethyl-benzenesulfonyl- amino)-N-( 1 -pyridin-2-yl-cyclohexyhnethyl)-propionamide; and (S)-2-(4-butyl-benzenesulfonylamino)-3-(lH-indol-3-yl)-2-methyl-N-(l- pyridin-2-yl-cyclohexylmethyl)-propionamide. The compounds of the general formulae above are optically active. The scope of the invention therefore also includes: • All stereoisomers of the compounds of the above general formulae. • The solvates, hydrates and polymorphs (different crystalline lattice descriptors) of the above compounds. • Pharmaceutical compositions of the above compounds. • Prodrugs of the above compounds such as would occur to a person skilled in the art; see Bundgaard et al., Ada Pharm. Suec ^ , 1987; 24: 233-246. The alkyl groups contemplated by the invention include straight, branched, or cyclic carbon chains of from 1 to 8 carbon atoms except where specifically stated otherwise. Representative groups are methyl ethyl, propyl, isopropyl, n-propyl, n-butyl, iso-butyl, sec-butyl, tert-butyl, 2-methylhexyl, n-pentyl, 1-methylbutyl, 2,2-dimethylbutyl, 2-methylpentyl, 2,2-dimethylpropyl, n-hexyl, and the like. The lower alkyl groups include carbon chains of up to 6 carbon atoms. The cycloalkyl groups contemplated by the invention comprise those having 3 to 7 carbon atoms including cyclopentyl and cyclohexyl. They may be substituted with from 1 to 3 groups selected from halogens, nitro, alkyl, and alkoxy. The alkoxy groups contemplated by the invention comprise both straight and branched carbon chains of from 1 to 6 carbon atoms unless otherwise stated. Representative groups are methoxy, ethoxy, propoxy, i-propoxy, t-butoxy, and hexoxy. The term "halogen" is intended to include fluorine, chlorine, bromine, and iodine. The term "amine" is intended to include free amino, alkylated amines, and acylated amines. The term "subject" includes animals, particularly mammals and more particularly humans. Optical isomers and salts The compounds of the above general formulae all have at least one chiral centre and some have multiple chiral centres depending on their structure. In particular, the compounds of the present invention may exist as diastereoisomers, mixtures of diastereoisomers, or as the mixed or the individual optical enantiomers. The present invention contemplates all such forms of the compounds. The mixtures of diastereoisomers are typically obtained as a result of the reactions described more fully below. Individual diastereoisomers maybe separated from mixtures of the diastereoisomers by conventional techniques such as column chromatography or repetitive recrystallization. Individual enantiomers may be separated by conventional methods well known in the art such as conversion to a salt with an optically active compound, followed by separation by chromatography or recrystallization and reconversion to the non-salt form. Where it is appropriate to form a salt, the pharmaceutically acceptable salts include acetate, benzenesulfonate, benzoate, bicarbonate, bitartrate, bromide, calcium acetate, camsylate, carbonate, chloride, citrate, dihydrochloride, edetate, edisylate, estolate, esylate, fumarate, gluceptate, gluconate, glutamate, glycoloylarsanilate, hexylresorcinate, hydrabamine, hydrobromide, hydrochloride, hydroxynaphthoate, iodide, isethionate, lactate, lactobionate, malate, maleate, mandelate, mesylate, methylbromide, methylnitrate, mucate, napsylate, nitrate, pamoate (embonate), pantothenate, phosphate/diphosphate, polygalacturonate, salicylate, stearate, subacetate, succinate, sulfate, tannate, tartrate, theoclate, triethiodide, benzathine, chloroprocaine, choline, diethanolamine, ethylenedi-imine, meglumine, procaine, aluminum, calcium, lithium, magnesium, potassium, sodium, and zinc. Preferred salts are made from strong acids. Such salts include hydrochloride, mesylate, and sulfate. Other non-peptide bombesin antagonists Other non-peptide bombesin antagonists which are believed to be suitable for use in the present invention are described and claimed in the following documents, the contents of which are incoφorated herein by reference: WO 00/09115, WO 00/09116, WO 92/07830, JP 07258081 and WO 98/07718. Preparative methods for the compounds of formula (I) Preparation of the compounds of formula (I) is described in WO 98/07718, the disclosure of which is incorporated herein by reference. Preparative methods for compounds of formula (II) Throughout this application the following abbreviations have the meanings listed below: NEt 3 triethylamine THF tetrahydrofuran HBTU O-benzotriazol- 1 -yl-NN,N',N'-tetramethyluronium hexafluorophosphate DIPEA N,N-diisopropylethylamine DMF NN-dimethylformamide TEBA benzyltriethylammonium chloride BOC2O di-tert-butyl dicafbonate TFA trifluoroacetic acid DMA N,N-dimethylacetamide EtOAc ethyl acetate MeOH methanol Trp tryptophan Ph phenyl HPLC high pressure liquid chromatography NP normal phase RP reverse phase DMAP N,N-dimethyl-4-amino pyridine OAc acetate OB oestradiol benzoate The production of compounds of the formula (II) in which X is oxazolyl is shown in Scheme 1 which illustrates the synthesis of the compounds of Examples 9 to 12 in four steps via Intermediates 4a or 4b. The steps are: Formation of the/?-mtrophenylcarbamate of the methyl ester (Intermediate 1) and subsequent treatment with aqueous ammonia to give a primary urea (Intermediate 2). Cyclisation of the primary urea with 2-bromo-l-(4-nitro-phenyl)-ethanone to form an oxazole ring (Intermediate 3). • Hydrolysis of the methyl-ester-protecting group gives Intermediates 4a or 4b. • Reaction of Intermediate 4a or 4b with the amine Z2, using HBTU to form an amide linkage, affords the desired compounds. Scheme 1: Intermediate 1, a-b Intermediate 2, a-b Intermediate 3, a-b a. Z1 = CH 2 iπdole b. Z1 = CH 2 Ph Id a-b Example 9, Z1 = CH 2 indole, Z2 = Ie Example 10, Z1 = CH 2 indole, Z2 = NJ><\oMe Example 11 , Z1 = CH 2 indole, Z2 ^O Example 12, Z1 = CH 2 Ph, Z2 = In the above scheme: i) a) 4-Nitrophenylchloroformate, NEt 3 , THF b) NH 3 aq. ii) 2-bromo-l-(4-nitro-phenyl)-ethanone in either toluene/dioxan at reflux (3 a) or 1,2-dichloroethane at reflux (3b) iii) LiOH, dioxan, H 2 O iv) HBTU, DIPEA, DMF, Z2 Scheme 2 describes the synthesis of the compounds of Examples 13 to 15 from Intermediate 2a. A primary urea 2a is cyclised with an appropriate bromomethyl ketone containing the group Z3 to form an oxazole ring (Intermediate 5). Hydrolysis of the methyl ester protecting group of the resulting Intermediate 5a, 5b or 5c gives the Intermediates 6 a-c. Reaction of an Intermediate 6a, 6b or 6c with [l-(5-methoxy-2- pyridyl)cyclohexyl]methanamine in the presence of HBTU to form an amide bond affords the desired compounds. Scheme 2: 5a, Z3 = 4-NCPhen 5b, Z3 = Phenyl- 5c, Z3 = Ethyl- Intermediate 2a Intermediate 5, a-c Intermediate 6, a-c In the above scheme: i) DMF at 30°C ii) LiOH, dioxan, H 2 O iii) HBTU, DIPEA, DMF, [l-(5-methoxy-2-pyridyl)cyclohexyl]methanamine (described in WO 98/07718) Scheme 3 describes a two step synthesis for the compounds of Examples 16-23. The reactions are preferentially carried out as a "one-pot" process in which: • An aromatic ring of a compound Z5-Br or Z5-C1 is appended onto the N- terminal of the illustrated amino acid using a copper catalysed reaction. • Formation of an amide linkage between the resulting acid and [l-(5-methoxy- 2-pyridyl)cyclohexyl]methanamine or [ 1 -(2-pyridyl)cyclohexyl]methylamine in the presence of HBTU affords the desired compounds. Scheme 3: Intermediate 7 Example 16 Z4=OMe Z5 = O,N x* Q Example 17 Z4=H Z5 = OO- Example 18 Z4=H Z5= * Example 19 Z4=H Z5 = N=rv Example 20 Z4=H Z5= <\ * Example 21 Z4=H Z5 = Example 22 Z4 =^ H Z5 . P' Example 23 In the above scheme: i) a) 10% Cul, K 2 CO 3 , DMF, 130°C b) HBTU, DIPEA, DMF, and [l-(5-methoxy-2-pyridyl)cyclohexyl]methan- amine (described in WO 98/07718) or [l-(2-pyridyl)cyclohexyl]methylamine (described in WO 98/07718) ii) a) 5-10% Cul, K 2 CO 3 , TEBA, Pd(P(ø-tolyl) 3 )Cl 2 , DMF, 130°C b) HBTU, DIPEA, DMF, and [l-(5-methoxy-2-ρyridyl)cyclohexyl]methan- amine (described in WO 98/07718) or [l-(2-pyridyl)cyclohexyl]methylamine (described in WO 98/07718) represents the attachment point. Scheme 4 describes the two step one-pot synthesis of the compound of Example 24: The aromatic ring is appended onto the N-terminal of the amino acid (Intermediate 8) using a copper catalysed reaction and then an in situ HBTU amide bond formation reaction affords the desired compound. Scheme 4: Intermediate 8 Example 24 In the above scheme: i) 10% Cul, K 2 CO 3 , DMA, 90°C ii) HBTU, NEt 3 , DMA, [l-(2-pyridyl)cyclohexyl]methylamine (described in WO 98/07718) Scheme 5 describes the synthesis of the compounds of Examples 25 - 27 via Intermediate 10 by the steps of : N-BOC protection of the amino acid (Intermediate 7) which provides the groups R 5 and Ar 1 . Reaction of the protected amino acid with an amine that provides the groups R 1 , R 2 , R 4 and R 6 using HBTU to form an amide linkage, and thereby give the Intermediate 9. N-BOC deprotection of the Intermediate 9 to give Intermediate 10. Reductive amination of Intermediate 10 with the appropriate aldehyde Z6CHO to give the desired compounds. Scheme 5: Intermediate 7 Intermediate 9 Intermediate 10 Exemple 25, Z6= In the above scheme: i) BOC 2 O, K 2 CO 3 , dioxane, water ii) HBTU, DIPEA, [l-(2-ρyridyl)cyclohexyl]methylamine (described in WO 98/07718), DMF iii) TFA, CH 2 C1 2 iv) NaBH(OAc) 3 , 1,2-dichloroethane. represents the attachment point. Scheme 6 describes the synthesis of Intermediate 13. • The alcohol 11 is methylated using sodium hydride. The resulting nitrile is reduced using Raney nickel under an atmosphere of hydrogen. Scheme 6: Intermediate 11 Intermediate 12 Intermediate 13 In the above scheme: i) NaH, CH 3 I, THF ii) Raney nickel, ethanolic ammonia, H 2 , 345 kPa Intermediate 13 C-(l-methoxymethyI-cyclohexyI)-methylamine Intermediate 13 The above compound was prepared as shown in Scheme 6. 1. Sodium hydride (862mg, 21.5mmol, 60% in oil) was taken up in THF (50ml) under argon at 0°C. To this was added a solution of methyl iodide (1.34ml, 21.6mmol) and 1-hydroxy-cyclohexanecarbonitrile (l.Og, 7.18mmol; see J. Frohlich et al, Heterocycles 1994, 37, 1879-91) in THF (30ml) dropwise over 45 minutes. Once addition was complete the reaction mixture was stirred at room temperature overnight, and then quenched with t-propanol followed by water (100ml). The mixture was then extracted with dichloromethane (2x150ml). The combined organic phases were dried (MgSO 4 ) and solvent removed under reduced pressure. Residue was purified by chromatography using heptane/ethyl acetate (4:1). Removal of solvent under reduced pressure gave 1-methoxymethyl-cyclohexanecarbonitrile (l.lg, 88%) as a pale yellow oil. IR (film): 2934, 2861, 2832, 2235, 1476, 1452, 1385, 1211, 1187, 1185, 1126, 1102,978,932,901,849 cm '1 ; 1H NMR (CDC1 3 ): δ = 1.13-1.33 (3H, m), 1.57-1.78 (5H, m), 1.94-2.02 (2H, m), 3.36 (IH, s), 3.42 (3H, s); 2. To the 1-methoxymethyl-cyclohexanecarbonitrile (l.lg, 7.2mmol) in ethanolic ammonia (60ml) was added Raney nickel catalyst (0.55g, pre-washed with water and ethanol). Reaction mixture was shaken for 16 hours under hydrogen (345 kPa) at 30°C. The catalyst was filtered off catalyst with extreme caution through a bed of Kieselguhr and washed with ethanol. Removal of the solvent under reduced pressure gave Intermediate 13 (1.12g, 99%) as a yellow oil. MS m/e (ES+): 158.2 (M + +H, 100%); IR(film): 2926, 2857, 1572, 1452, 1378, 1316, 1190, 1140, 966 cm '1 ; 1H NMR (CDC1 3 ): δ = 1.20-1.60 (12H, m), 2.62 (2H, s), 3.23 (2H, s), 3.32 (3H, s) Preparative methods for compounds of formula (HI) Compounds of the formula (DI) in which X is -CO- can be prepared by condensing an acid of the formula (DTI) Ar - (CH 2 ) k -COOH (III-l) or a derivative thereof with an amine of the formula (ID-2) in an aprotic polar solvent in the presence of an appropriate catalyst, the values of the substituents Ar, Ar 1 and R 1 to R 6 and the parameters k to n being as defined above with reference to formula (DT), and optionahy converting the resulting product to a pharmaceutically acceptable salt. For example, the condensation may be carried out in dimethylformamide using O-benzotriazol-l-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate (HBTU) and NN-diisopropyl-ethylamine (DIPEA) as catalyst. Compounds of the formula (ID) in which X is -OC(=O)- can be prepared by forming a carbonate from an alcohol of the formula (ID-3) Ar - (CH 2 ) k -OH (III-3) and reacting the carbonate with an amine of the formula (ID-2) in an aprotic polar solvent in the presence of a base, the values of the substituents Ar, Ar 1 and R 1 to R 6 and the parameters k to n being as defined above with reference to formula (TU), and optionally converting the resulting product to a pharmaceutically acceptable salt. For example, the compound of formula (DI-3) may be reacted with 4- nitrophenyl chloroformate in dichloromethane using pyridine as catalyst, and the resulting carbonate may be reacted with the amine of formula (HI-2) in dimethyl formamide using N, N-dimethyl-4-amino pyridine as catalyst. Compounds of the formula (TTT) in which X is -SO 2 - can be prepared by condensing a sulfonyl chloride of the formula (ffi-4) Ar - (CH 2 ) k -SO 2 Cl (IH-4) with an amine of the formula (ID-2) in an aprotic polar solvent in the presence of a base as catalyst, the values of the substituents Ar, Ar 1 and R 1 to R 6 and the parameters k to n being as defined above with reference to formula (ID), and optionally converting the resulting product to a pharmaceutically acceptable salt. For example, the condensation may be carried out in dimethylformamide in the presence of N,N-diisopropylethylamine and NN-dimethyl- 4-aminopyridine. In the above methods, the amine of formula (ITI-2) is preferably a chiral amine of formula (ID-5) wherein the pyridine ring is optionally substituted by with 1 or 2 substituents R and R' selected from alkoxy, cyano, halogen, nitro, phenyl, phenoxy, - CF 3 , - (CH 2 ) q NR 7 R 8 , wherein R 7 and R 8 can form a ring of between 5 to 7 atoms, which may contain 1 or 2 oxygen or nitrogen atoms, or R 7 and R 8 can be independently selected from hydrogen or cyclic alkyl of from 1 to 5 carbon atoms, methoxy being a particularly preferred substituent, as in the chiral amine (DI-6): B) Peptide bombesin receptor antagonists Bombesin antagonists which are peptides and which are believed to be suitable for use in the present invention are described in the following documents, the contents of which are incorporated herein by reference: Pharmaceutical compositions For preparing pharmaceutical compositions from the compounds of this invention, inert, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, dispersible granules, capsules, sachets, and suppositories. A solid carrier can be one or more substances which may also act as diluents, flavouring agents, solubihzers, lubricants, suspending agents, binders, or tablet disintegrating agents; it can also be an encapsulating material. In powders, the carrier is a finely divided solid which is in a mixture with the finely divided active component. In tablets, the active component is mixed with the carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain 5% to about 70% of the active component. Suitable carriers are magnesium carbonate, magnesium stearate, talc, lactose, sugar, pectin, dextrin, starch, tragacanth, methyl cellulose, sodium carboxymethyl cellulose, a low-melting wax, cocoa butter, and the like. Liquid form preparations include solutions, suspensions, and emulsions. Sterile water or water-propylene glycol solutions of the active compounds may be mentioned as an example of liquid preparations suitable for parenteral administration. Liquid preparations can also be formulated in solution in aqueous polyethylene glycol solution. Aqueous solutions for oral administration can be prepared by dissolving the active component in water and adding suitable colorants, flavouring agents, stabilizers, and thickening agents as desired. Aqueous suspensions for oral use can be made by dispersing the finely divided active component in water together with a viscous material such as natural synthetic gums, resins, methyl cellulose, sodium carboxymethyl cellulose, and other suspending agents known to the pharmaceutical formulation art. Preferably the pharmaceutical preparation is in unit dosage form. In such form, the preparation is divided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of the preparation, for example, packeted tablets, capsules, and powders in vials or ampoules. The unit dosage form can also be a capsule, sachet, or tablet itself, or it can be the appropriate number of any of these packaged forms. For preparing suppository preparations, a low-melting wax such as a mixture of fatty acid glycerides and cocoa butter is first melted and the active ingredient is dispersed therein by, for example, stirring. The molten homogeneous mixture is then poured into convenient sized moulds and allowed to cool and solidify. Compositions that are adapted for oral administration to humans are preferred, especially such compositions in unit dosage form. Combination therapy Without wishing to be bound by any particular theory or teaching, the inventors believe that bombesin receptor antagonists could be used as part of a medicament in combination with one or more vasodilator, hormone therapy or neurotransmitter modulator. Such products are used or tested in the treatment of sexual dysfunction. Vasodilators for the treatment of sexual dysfunctions of organic (rather than psychogenic) origin, act at the penis, clitoris or vagina level on local blood flow or lubricant secretions. Vasodilators useful for the treatment of sexual dysfunction include alprostadil or phentolamine, NO (nitric oxide) enhancers such as L-arginine, and PDE5 inhibitors such as sildenafil or a pharmaceutically acceptable salt thereof (Scrip 's Complete Guide to Women's Healthcare, p.194-205, 2000)(Sachs B.D., Neuroscience and Biobehavioral Review , 2000, 24 541-560, Benet and Mehnan, 1995, Urol. Clin.N. Amer. 22:699-709), NIP (Naso Intestinal Peptide) enhancers (Scrip's Complete Guide to Women's Healthcare, p.194-205, 2000) or angiotensin-2 receptor antagonists such as losartan (American Heart Association meeting, New Orleans, 2000). Hormone therapies useful in the treatment of sexual dysfunction of organic and psychogenic nature include modulators of steroid hormones, steroid hormones or hormone product (including synthetic hormones) including oestrogen (Scrip's Complete Guide to Women's Healthcare, p.194-205, 2000), or androgens such as testosterone (Scrip's Complete Guide to Women's Healthcare, p.194-205, 2000, Sachs B.D., Neuroscience and Biobehavioral Review, 2000, 24 541-560), which act in areas of the CNS associated with sexual desire and sexual arousal (Wilson CA. Pharmacological targets for the control of male and female sexual behaviour. In: Sexual Pharmacology, Riley AJ, Peet M, Wilson CA (Eds), Clarendon Press, Oxford. 1993:1-58). Neurotransmitter modulators useful in the treatment of both psychogenic and organic sexual dysfunction include neurotransmitter agonists and antagonists such as catecholamine agonists such as the D2 agonist quinelorane, 5HT2 antagonists such as ritanserin, monoamine synthesis modifiers such as treatments that reduce endogenous 5HT activity, including inhibition of 5HT synthesis using para- chlorophenylalanine, monoamine metabolism or uptake modifiers that inhibit catecholamine metabolism or reuptake, such as tricyclic antidepressants, e.g. imipramine (Wilson CA. Pharmacological targets for the control of male and female sexual behaviour. In: Sexual Pharmacology, Riley AJ, Peet M, Wilson CA (Eds), Clarendon Press, Oxford. 1993:1-58). The use of this combination therapy includes the preparation of therapies that would allow administration of both components of the medicament, i.e. bombesin receptor antagonists and a vasodilator, hormone therapy medicament or neurotransmitter modulator medicament in a single dose. A preferred formulation would allow oral administration. However, administration by suppository, cream, transdermal patch or injection is also part of this invention. Alternatively the inventors envisage formulations which allow administration of the bombesin receptor antagonist via a separate route to that of the vasodilator, hormone therapy medicament or neurotransmitter modulator medicament. Such routes could include for example oral administration of the bombesin receptor antagonist and transdermal patch application of the vasodilator. Thus there may be provided a kit in which unit doses of bombesin receptor antagonist occur in association with unit doses of the vasodilator, hormone therapy medicament or neurotransmitter modulator medicament. For example, in the case of a kit where bombesin receptor antagonist is formulated as a tablet capsule or other unit dosage form for oral administration and the vasodilator is provided as a transdermal patch, the two dosage forms could be provided in the form of a two-row tear-off strip in which compartments containing the tablets, etc. occur above compartments containing the transdermal patches. Other forms of packaging in which the two dosage forms are spatially associated so as to make it easy for patients to take them together and to be reminded when they have done so will readily occur to those skilled in the art. The kit will also contain instructions as to when and how the individual components of the kit should be administered. How the invention may be put into effect will now be described, by way of example only, with reference to the following examples, some of which are preparative and others of which describe results of biological tests. Example 1 Effect of (S) 3-(lH-IndoI-3-yl)-N-[l-(5-methoxy-pyridin-2-yI)-cyclohexyl-methylI- 2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide (Compound (1)) on female rat sexual proceptivity Ovariectomised adult female Sprague Dawley rats (180-200g, from Charles River) were housed in groups of 6 in a reversed lighting system of 12h light: dark (lights off 7.00-19.00h). Two weeks after ovariectomy they were used for sexual activity tests. The experiments started at least 5h into the dark period. Tests were carried out in a circular arena of 90cm diameter, surrounded by a 30cm high wall. Two small cages with wire-mesh front (15x15cm) are fixed into the wall such that the front of the cage is «flush» with the wall and the 2 cages are opposite each other. They contained two stimuli animals: an intact sexually experienced male and a receptive female (ovariectomised, primed with 5μg oestradiol benzoate dissolved in com oil and injected subcutaneously 48 hours before the test and with 0.5 mg of progesterone four hours before the test). Sexually naive test and control animals were used. Forty eight hours before the tests, both the test and control animals were primed with 5μg oestradiol benzoate. For animals used as positive controls, progesterone (0.5mg/0.1ml) was dissolved in corn oil and administered subcutaneously (s.c), 4h before the test. Test and control animals were introduced one at a time for 10 minute periods into the arena. During the lOmin test, the time that the test or positive control animal spent investigating each stimulus animal was noted. The arena was thoroughly cleaned between animals. The position of the male/female stimuli boxes was randomised between animals, in order to avoid place preference. The difference in the percentage of time spent investigating the male minus the female stimuli was calculated, out of the total time spent investigating stimuli animals. Compound (I) was dissolved in 100% β-cyclodextrin and then diluted with saline to a final solution of 50% 2-hydroxypropyl-β-cyclodextrin. It was administered intraperitoneally (i.p.) at doses of 3 and lOmg/kg, in a dosing volume of lml/kg, lh before tests. Progesterone (0.5mg/0.1ml) was dissolved in com oil and administered subcutaneously (s.c), 4h before test, as a positive control. Compound (V) dose-dependently (3mg/kg-10mg/kg) increased the percentage of time spent investigating the male stimulus, with a MED of lOmg/kg (see Figure 1). The effect of this dose was similar to the effect of progesterone (prog). (*P<0.05, **P<0.01 Kruskal-Wallis followed by Mann- Whitney test, vs vehicle). Example 2 Effect of Compound (1) on female rat sexual receptivity Ovariectomised adult female Sprague Dawley rats (180-200g, from Charles River) were housed in groups of 6 in a reversed lighting system of 12h ligh dark (lights off 7.00-19.00h). Two weeks after ovariectomy they were used for sexual activity tests. The experiments started at least 5h into the dark period. Compound (1) was dissolved in 100% β-cyclodextrin and then diluted with saline to a final solution of 50% 2-hydroxypropyl-β-cyclodextrin. It was administered intraperitoneally (i.p.) at a dose of lOmg/kg, in a dosing volume of lml/kg. Quinelorane (6.25μg/kg) was dissolved in water and administered s.c. as positive control. Forty eight hours before testing, ovariectomised female rats (as described above), were primed with 5μg oestradiol benzoate dissolved in corn oil and injected subcutaneously. This is a low dose of oestrogen that does not re-establish sexual behaviour in an ovariectomised female but provides a minimum hormonal background for pharmacological agents to stimulate sexual behaviour. The females were placed with a series of vigorous male rats and subjected to 10 mounts. The lordotic response of the animal was recorded and expressed as a percentage of the mounts (i.e. lordosis quotient, LQ), as previously described. Animals showing LQ<20 were considered non-receptive and were included in the study. Each rat was tested prior to administration of the compound and then tested similarly post-injection. The pre-treatment times were lh for Compound (1) and vehicle (50% β-cyclodextrin, i.p.) or 90min for quinelorane. As shown in Figure 2, a single administration of quinelorane (6.25μg/kg, s.c.) significantly (PO.01) increased the LQ, 90min after administration, compared to the LQ shown before administration (paired t test). A single administration of Compound (!) (lOmg/kg, i.p.) also had a significant (PO.05) stimulatory effect on the LQ, lh after administration, compared to the LQ shown before administration (paired t test). Example 3 The effect of repeated administration of Compound (1) on female rat proceptivity In the present study we have investigated whether the repeated administration of a higher dose of Compound (V) (15mg/kg) still results in stimulation of proceptivity. Ovariectomised adult female Sprague Dawley rats (180-200g) were housed in groups of 5 in a reversed lighting system of 12h lightdark (lights off 5.00-17.00h). They were used for the experiments at least two weeks after ovariectomy. Forty eight hours before tests, the animals were primed with oestradiol benzoate (5μg/0.1ml in com oil, s.c). On day 1, progesterone (0.5mg/0.1ml, in com oil, s.c.) was administered to one of the groups 4h before tests, as a positive control. Compound (T) (15mg/kg, i.p.) was administered in 50% 2-hydroxypropyl-β-cyclodextrin, lh before tests. The test lasted 10 minutes and was carried out as described before. The difference in the percentage of time spent investigating the male minus the female stimuli was calculated, out of the total time spent investigating stimuli animals. Animals were submitted to a test on day 1 and on day 15. From day 2 to 14 the Compound (X) group received a daily injection of the compound (15mg/kg, i.p.), while both the vehicle and the progesterone groups received an injection of vehicle. On day 15 the test took place again, as described for day 1. On day 1, both progesterone and Compound (1) had a stimulatory effect on proceptivity, compared to the vehicle group (**P<0.01, ANONA followed by Dunnett's test). On day 15, a similar stimulatory effect was observed (**P<0.01, AΝONA followed by Dunnett's test) (see Figure 3). No significant difference was observed between the effects on day 1 and day 15 for each treatment group (paired t test). The effects of progesterone and Compound (V) were statistically similar. There were no changes in body weight or general behaviour between groups along the experiment. From this study we can conclude that Compound (1) (15mg/kg, i.p.) has a stimulatory effect on proceptivity in the female rat, comparable to progesterone, and that such effect is unaffected by the repeated adinihistration of the compound, which seems to be well tolerated. Example 4 Effect of intracerebroventricular administration of Compound ( ) on female rat sexual proceptivity In order to elucidate the site of action for this effect we have administered the Compound (1) intracerebroventricularly (i.c.v.). Ovariectomised female rats (Sprague Dawley, obtained from Charles River, UK) were stereotaxically implanted (coordinates 0.89mm behind Bregma, 1.3mm lateral and 2.5mm vertical) with stainless steel cannulae (6 mm long, O.D. 0.75mm), held in place with dental cement. Animals were housed in groups of three and returned to a reversed lighting system of 12h lightidark (lights off 5.00-17.00h). Correct placement of the cannulae was assessed post-mortem. Rats were used for tests two weeks after ovariectomy (one week after cannulation). The experiments started at least 5h into the dark period. Forty eight hours before tests, the animals were primed with 5μg oestradiol benzoate (s.c, in com oil) and adapted to the apparatus (in the absence of stimuli animals) for lOmin on 2 consecutive days prior testing. The lOmin test was carried out as previously described. The difference in the percentage of time spent investigating the male minus the female stimuli was calculated, out of the total time spent investigating stimuli. Compound (1) was dissolved in 50% 2-hydroxypropyl-β-cyclodextrin in saline. It was administered i.c.v. over a 30sec period, with the aid of a pump set to deliver a flow of lOμl/min. The dosing volume was 5j-.l/rat. The compounds were administered lOmin before tests. Progesterone (0.5mg/0.1ml) was dissolved in com oil and administered subcutaneously (s.c), 4h before test, as a positive control. As shown in Figure 4, Compound (1) dose-dependently (3-30μg/rat) increased the percentage of time spent investigating the male stimulus, with a MED of lOμg. The effect of this dose was similar to the effect of progesterone. From this study we can conclude that the effect of Compound (V) on female sexual proceptivity is centrally mediated. In figure 4 bars represent percentage of time spent investigating male, minus the percentage of time spent investigating the female stimuli+SEM, (n=7-8 per group). *P<0.05, **P<0.01 vs vehicle (Kruskal-Wallis ANONA test followed by Mann- Whitney's test). Example 5 Inhibitory effect of ΝMB on female rat sexual proceptivity and antagonism of this effect by Compound (1) We have investigated the potentially inhibitory effect of the BBi agonist neuromedin B (NMB) on female rat sexual proceptivity. Ovariectomised female rats (Sprague Dawley, obtained from Charles River, UK) were stereotaxically implanted (coordinates 0.89mm behind Bregma, 1.3mm lateral and 2.5mm vertical) with stainless steel cannulae (6 mm long, O.D. 0.75mm), held in place with dental cement. Animals were housed in groups of three and returned to a reversed lighting system of 12h lightdark (lights off 5.00-17. OOh). Correct placement of the cannulae was assessed post-mortem. Rats were used for tests two weeks after ovariectomy (one week after cannulation). The experiments started at least 5h into the dark period. Forty eight hours before tests, the animals were primed with 5μg oestradiol benzoate (OB) (s.c, in com oil) and adapted to the apparatus (in the absence of stimuli animals) for lOmin on 2 consecutive days prior testing. The lOmin test was carried out as previously described. The difference in the percentage of time spent investigating male minus female was calculated, out of the total time spent investigating stimuli. Progesterone (Prog, 0.5mg/0.1ml) was dissolved in com oil and administered subcutaneously (s.c), 4h before test, to induce proceptive behaviour. Compound (1) (15mg kg, i.p.) was dissolved in 50% 2-hydroxypropyl-β-cyclodextrin in saline and administered lh before the i.c.v. administration. Neuromedin B was obtained from Bachem, UK. It was dissolved in isotonic saline and administered i.c.v. over a 30sec period, with the aid of a pump set to deliver a flow of lO l/min, lOmin before tests. The dosing volume was 5j-.l/rat. Each rat received a total amount of lOOng. As shown in Figure 5, progesterone (Prog) increased the percentage of time spent investigating the male stimulus, compared to the vehicle group, thus showing stimulation of proceptive behaviour. NMB (lOOng, i.c.v.) significantly reduced proceptivity in progesterone-treated rats. Moreover, pre-treatment with Compound (V) which acts as an antagonist (15mg/kg, i.p.) prevented the inhibitory effect of NMB. However, the blockade obtained with the dose of Compound (1) used was not total. From the present study we can conclude that stimulation of BB1 receptors with an agonist results in inhibition of proceptive behaviour. This inhibitory effect may be prevented by the presence of an antagonist, e.g. Compound (1) i figure 5 the bars represent percentage of time spent investigating male, minus the percentage of time spent investigating the female stimuli+SEM, (n=8-12 per group). ***P<0.001 vs progesterone (One-way ANONA followed by Dunnett's test). Example 6 Demonstration that the effect of Compound (I) on female sexual behaviour is not mediated through sexual hormones Previous examples have shown that Compound (1) (nanomolar affinity "mixed" BBι/BB 2 receptor antagonist) has a dose-dependent stimulatory effect on sexual activity in the female rat, both on proceptivity and receptivity. Although the animals used in that study were ovariectomised, and therefore steroid hormones release can not be expected to occur in response to the compound, there is a possibility that the adrenal glands might secrete steroid hormones in response to Compound (1). If that was the case, the mediation of the stimulatory effects by progesterone would be relevant for rodents, but it would not be the case for primates. In the present study, we have investigated the potential effect of the bombesin receptor antagonist Compound (I) on secretion of progesterone. Oestradiol and pituitary hormones (Luteinising hormone (LH), follicle stimulating hormone (FSH) and prolactin) have also been analysed in the same animals. Ovariectomised adult female Sprague Dawley rats (180-200g) were housed in groups of 6 in a reversed lighting system of 12h lightdark (lights off 7.00-19.00h). They were used for the experiments at least two weeks after ovariectomy. Forty eight hours before tests, the animals were primed with oestradiol benzoate (5μg/0.1ml in com oil, s.c). Progesterone (0.5mg/0.1ml, in corn oil, s.c.) was administered 4h before blood collection, as a positive control. Compound (1) (3-lOmg/kg, i.p.) was administered in 50% 2-hydroxypropyl-β-cyclodextrin, lh prior to blood collection. Blood was collected from the trunk, after decapitation. It was immediately centrifuged (3500r.p.m., 4°C, 5min) and the plasmas frozen until assayed for hormonal content, 1 c using commercially available radioimmunoassay kits ( I-labelled hormones) for oestradiol, progesterone, LH, FSH and prolactin. A single administration of progesterone resulted in a significant increase in the progesterone plasma levels (P<0.05), and a significant decrease in LH plasma levels (PO.01), compared to animals injected with vehicle (Kruskal-Wallis followed by Mann- Whitney test). However, Compound (I) (3-lOmg/kg, i.p.) had no effect on the plasma levels of progesterone (Figure 6, where animals were pre-treated with 5μg oestradiol benzoate, s.c, 48h before the test. They were tested lh or 4h post-injection of Compound (1) (3-10mg/kg, p.o.) or progesterone (0.5mg/0.1ml, s.c.) respectively. Nalues represent mean±SEM, (n=9 per group). *P<0.05, vs vehicle (Kraskal-Wallis followed by Mann- Whitney test, vs vehicle)), oestradiol (Figure 7, where animals were pre-treated with 5μg oestradiol benzoate, s.c, 48h before the test. They were tested lh or 4h post-injection of Compound (1) (3-10mg/kg, p.o.) or progesterone (0.5mg/0.1ml, s.c.) respectively. Nalues represent mean±SEM, (n=6-7 per group)), prolactin (Figure 8, where animals were pre-treated with 5μg oestradiol benzoate, s.c, 48h before the test. They were tested lh or 4h post-injection of Compound (1) (3- lOmg/kg, p.o.) or progesterone (0.5mg/0.1ml, s.c.) respectively. Nalues represent mean±SEM, (n=10 per group)) LH (Figure 9, where animals were pre-treated with 5μg oestradiol benzoate, s.c, 48h before the test. They were tested lh or 4h post- injection of Compound (1) (3-10mg/kg, p.o.) or progesterone (0.5mg/0.1ml, s.c.) respectively. Nalues represent mean±SEM, (n=10 per group). **P<0.01, vs vehicle (Kruskal-Wallis followed by Mann- Whitney test, vs vehicle)) or FSH (Figure 10, where animals were pre-treated with 5μg oestradiol benzoate, s.c, 48h before the test. They were tested lh or 4h post-injection of Compound (1) (3-10mg/kg, p.o.) or progesterone (0.5mg/0.1ml, s.c.) respectively. Nalues represent mean±SEM, (n=10 per group). From this experiment we can conclude that Compound (V) did not have an effect on the secretion of sexual hormones, thus suggesting that the effects of the compound on female sexual activity must be mediated by different mechanisms, maybe involving neurotransmitters. Example 7 Effect of Compound (1) on the sexual behaviour of normal male rats The potentially stimulatory effect of Compound (1) on male sexual behaviour has been tested on sexually vigorous rats. Sprague Dawley male rats (Charles River, UK) were kept, 4 rats per cage, in a reversed lighting regime (12:12 hours, lights off at 5.00 h), with free access to food and water. The rats were pre-selected by being presented with a receptive female at 4 days intervals, i.e. every third day (having 2 clear days between presentations) until completing 6-7 days of baseline determination. The animals showing consistently vigorous behaviour (ejaculatory latencies <300s) were chosen for further experiments (n=24). Animals were randomised into three groups. All animals received all three treatments following a latin-square design. Treatments were administered once a week, with a baseline test in between treatments (4 days intervals between baseline and test day). Treatments were Compound (I) (15mg/kg, dissolved in 50% 2-hydroxypropyl-β-cyclodextrin in saline), vehicle, or Fluoxetine (20mg/kg dissolved in 100% DMSO). All treatments were administered i.p. in a lml/kg volume, lh before tests. For all the sexual behaviour tests, the males were placed in an observation arena (50-60 cm diameter), starting 5 hours into the dark cycle and observed under red illumination. Three to 4 minutes after placing the male in the arena, a receptive female (ovariectomised, bearing a 7 mm Silastic implant of oestradiol benzoate) was introduced to the arena and the following parameters noted: Mount Latency: time (in seconds) taken between introduction of female and first mount. A maximum time of 15 minutes (900 seconds) was allowed, and the test terminated if no mounts were recorded within that time (Figure 11), Intromission Latency: time (in seconds) taken between introduction of female and first intromission (Figure 12), Number of Mounts: to reach ejaculation. When ejaculation was not reached, the number of mounts was not analyzed, Number of Intromissions: to reach ejaculation. When ejaculation was not reached, the number of ώtromissions was not analyzed (Figure 13 is number of mounts + intromissions), Ejaculation Latency: time (in seconds) taken from first intromission to ejaculation. A maximum time of 30 minutes (1800 seconds) was given, and the test terminated if ejaculation was not achieved in that time (Figure 14), and Refractory Period: time (in seconds) taken from ejaculation to the first mount of the next series of sexual activity. In those animals reaching ejaculation the test was terminated at the end of the refractory period, as indicated by the first mount of the next sexual cycle (Figure 15). A one-way ANONA followed by Dunnett's t test was used to compare treated vs vehicle groups each day of testing, for all the sexual behaviour parameters. (*P<0.05, **P<0.01; n=15-16). Mount latency and intromission latency were significantly increased in the fluoxetine-treated group compared to the vehicle group. Ejaculation latency and refractory period were also increased in this group, showing a decrease in sexual performance as well as the decreased arousal. No changes were seen in the number of mounts and intromissions required to achieve ejaculation. Unlike Fluoxetine, Compound (I) had no effect on any of the parameters studied, at a dose shown to be stimulatory in sexually dysfunctional males (see example 9). From the present study we can conclude that Compound (1) has no effect on sexual behaviour in sexually vigorous males. Example 8 Effect of Compound (1) on the sexual behaviour of sexually dysfunctional male rats Fluoxetine induces ejaculation delay, anorgasmy and loss of sexual desire in humans (Crenshaw and Goldberg, 1996). A model of male sexual dysfunction in the rat, induced by daily administration of fluoxetine until a significant detrimental effect on sexual behaviour (arousal and ejaculation) was established. The potentially stimulatory effect of Compound (1) on male sexual behaviour in these sexually dysfunctional male rats was examined. The effects of Compound (1) were compared to those of yohimbine. Preclinical and clinical studies suggest that yohimbine may be an effective treatment for sexual side-effects caused SSRI (Hollander, E., McCarley, A. (1993) J. Clin. Psychiatry 53:207-209. and Jacobsen). Sprague Dawley male rats (Charles River, UK) were kept, 4 rats per cage, in a reversed lighting regime (12:12 hours, lights off at 5.00 h), with free access to food and water. The rats were pre-selected by being presented with a receptive female at 4 days intervals, i.e. every third day (having 2 clear days between presentations) until completing 6-7 trials of baseline determination. The animals showing consistently vigorous behaviour (ejaculatory latencies <300s) were chosen for further experiments. Animals were treated for 3 consecutive days with either vehicle (water) or fluoxetine (20mg/kg, i.p., in a 2ml/kg dosing volume). On the fourth day, the animals treated with water received vehicle (veh+veh) and the animals treated with fluoxetine received one of the three following treatments: Compound (V) (15mg/kg, dissolved in 50% 2-hydroxypropyl-β-cyclodextrin in saline), vehicle (cyclodextrine), or yohimbine (2mg/kg dissolved in water). All treatments were administered i.p. in a lml kg volume, lh before tests. For all the sexual behaviour tests, the males were placed in an observation arena (50-60 cm diameter), starting 5 hours into the dark cycle and observed under red illumination. Three to 4 minutes after placing the male in the arena, a receptive female (ovariectomised, bearing a 7 mm Silastic implant of oestradiol benzoate) was introduced to the arena and the following parameters noted: Mount Latency: time (in seconds) taken between introduction of female and first mount. A maximum time of 15 minutes (900 seconds) was allowed, and the test terminated if no mounts were recorded within that time (Figure 16), Ejaculation Latency: time (in seconds) taken from first intromission to ejaculation. A maximum time of 30 minutes (1800 seconds) was given, and the test teiminated if ejaculation was not achieved in that time (Figure 17), Percentage of males achieving ejaculation within 30 minutes was calculated (Figure 18). A one-way ANONA followed by Dunnett's t test was used to compare the fluoxetine+vehicle group and other groups for mount and ejaculatory latencies. Percentage of animals ejaculating was analysed using a Chi-square test followed by Fisher's test. (*: PO.05, **: P<0.01, ***: P<0.001; n=15-19). Mount latency and ejaculation latency were significantly increased in the fluoxetine-treated groups compared to the vehicle+vehicle group, indicating a decrease in sexual desire as well as sexual performance in these groups. The number of animals ejaculating was sigmficantly lower in the fluoxetine-treated groups, indicating anorgasmy. Compound (1) sigmficantly decreased the mount and ejaculatory latencies at the same time as increasing the percentage of animals ejaculating in the animals rendered sexually dysfunctional by the fluoxetine treatment, to levels comparable to normal animals (veh+veh). Yohimbine followed a similar trend, although this did not reach significance. From the present study we can conclude a stimulatory effect of Compound (£) on sexual behaviour in males suffering from sexual dysfunction, at the level of sexual desire, sexual performance and anorgasmy. Example 9 (S)-3-(lJΪ-Indol-3-yl)-iV-[l-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl- 2-[4-(4-nitro-phenyl)-oxazol-2-ylamino]-propionamide 1. To a stirred solution of p-nitrophenylchloro formate (9.27g, 46mmol) in THF (200ml) at 0°C was added dropwise a solution of H-(S)-oMeTrρ-OMe (la) (10.7g, 46 mmol) and triethylamine (6.4ml, 46mmol) in THF (100ml) over 1 hour. Stirring was continued for a further 30 minutes at room temperature, after which aqueous ammonia (15ml) was added. IR after 10 minutes indicated bands at 1732 and 1660 cm "1 . The THF was removed under reduced pressure, and the residue was taken up in EtOAc and washed with IN HCl (x2), Na 2 CO 3 solution (until intense yellow colour subsided, ~x8), brine, and dried (MgSO 4 ). The solvent was removed under reduced pressure to give 2a as a foam (10.3g, 82%):MS m/e (AP+): 276.16 (M* + H, 100%); MS m/e (AP-): 274.11 (M- H, 100%); IR (film): 3383, 1724, 1657, 1600, 1539, 1456, 1374, 1256, 1108, 743 cm "1 ; 1H NMR (CDCI 3 ): δ= 1.70 (3H, s), 3.38 (IH, d, J=14.7 Hz), 3.59 (IH, d, J=14.7 Hz), 3.71 (3H, s), 4.22 (2H, s), 5.16 (IH, s), 6.99 (IH, d, J=2.2 Hz), 7.08-7.20 (2H, m), 7.34 (IH, d, J=8.1 Hz), 7.59 (IH, d, J=7.8 Hz), 8.09 (IH, s). 2. The urea (2a) (6.4g, 23mmol) and 2-bromo-l-(4-mtro-phenyl)-ethanone (6.0g, 23mmol) were stirred in toluene (500ml)/dioxan (100ml) and maintained under reflux for 30 hours, after which solvent was removed under reduced pressure and the residue was purified by chromatography using a 90g Biotage cartridge. 10% EtOAc in heptane eluted the bromide starting material. 20% EtOAc eluted the desired product. Removal of solvent under reduced pressure gave 3a as a foam (840mg, 9%): MS m/e (ES+): 420.56 (M 1" , 100%); TR(film): 3394, 1732, 1632, 1605, 1574, 1515, 1456, 1334, 1253, 1210, 1108, 1072, 940, 854, 734 cm "1 ; 1H NMR (CDC1 3 ): δ= 1.91 (3H, s), 3.46 (IH, d, J=14.6 Hz), 3.69 (3H, s), 3.78 (IH, d, J=14.6 Hz), 5.57 (IH, s), 6.89 (IH, d, J=2.2 Hz), 7.03-7.08 (IH, m), 7.14-7.18 (IH, m), 7.34 (IH, d, J=8.1 Hz), 7.41 (IH, d, J=8.1 Hz), 7.63 (IH, s), 7.85 (2H, d, J=9.0 Hz), 8.05 (IH, s), 8.24 (2H, d, J=8.6 Hz). 3. The ester (3 a) (840mg, 2mmol) was dissolved in dioxan (50ml) and LiOH.H 2 0 (33 mg, 8mmol) in H 2 O (25ml) was added. The mixture was stirred vigorously overnight, and then neutralised with IM HCl (8ml, 8mmol). The majority of the dioxan was removed under reduced pressure and the product was crystallised, filtered off, washed with water and dried under reduced pressure to give pure 4a (668mg, 82%): MS m/e (ES+): 407 (IVT + H); IR film/. lόSS cm- 1 ; 1H NMR (DMSO-d 6 ) δ= 1.49 (3H, s), 3.30-3.35 (IH, m, masked by H 2 0), 3.59 (IH, d, J=14.7 Hz), 6.86-6.90 (IH, m), 6.99-7.03 (2H, m), 7.30-7.36 (2H, m), 7.48 (IH, s), 7.94 (2H, d, J=9.0 Hz), 8.27-8.30 (3H, m), 10.88 (IH, s), (C0 2 H not seen). 4. The acid (4a) (1.148g, 2.8mmol), O-benzotriazol-l-yl-N,N,N',N'- tetramethyluronium hexafluorophosphate (HBTU, 1.06g, 2.8mmol), and N,N- diisopropylethylamine (DIPEA, 490μl, 2.8mmol) were stiπed in DMF (10ml) for 5 minutes before adding DIPEA (490μl, 2.8mmol) and [l-(5-methoxy-2- pyridyl)cyclohexyl]-methanamine (see WO 98/07718, 678mg, 3.1mmol). HPLC indicated that reaction was complete within 1 hour. Solvent was removed under reduced pressure and the residue was taken up in EtOAc The organic layer was washed with brine, saturated ΝaHCO 3 (x3), brine and dried (MgSO 4 ), after which solvent was removed under reduced pressure. The residue was purified by chromatography using RP silica with 65% MeOH in H 2 O. Pure fractions were evaporated to give the desired product as an amorphous solid (1.12g, 66%): MPt: 100-105°C; MS m/e (ES+): 609.63 (M + + H, 100%); TR (film): 3359, 3272, 3054, 2932, 2857, 1628, 1606, 1573, 1515, 1488, 1393, 1336, 1268, 1232, 1181, 1150, 1131, 1097, 1028, 1012, 962, 939, 900, 853, 831, 737 cm 1H NMR (CDC1 3 ): δ= 1.10-1.60 (8H, m), 1.72 (3H, s), 1.95-2.02 (2H, m), 3.31-3.42 (2H, m), 3.41 (IH, d, J=14.6 Hz), 3.50 (IH, d, J=14.6 Hz), 3.69 (3H, s), 5.34 (IH, s), 6.90-6.97 (2H, m), 7.04-7.09 (2H, m,) 7.14-7.19 (IH, m), 7.33 (IH, d, J=8.1 Hz), 7.46 (IH, d, J=7.8 Hz), 7.54 (IH, s), 7.77 (2H, d, J=8.8 Hz), 8.00 (IH, d, J=2.9 Hz), 8.04 (IH, s), 8.21 (2H, d, J=8.8 Hz); (amide masked by CHCl 3 ) HPLC A: Rt. 11.86 min, 99.8/100% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at 1ml min "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm; HPLC B: Rt. 14.32 min, 100/100% purity, 80:20 methanol/Tris buffer at pH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm. Example 10 (S)-3-(l-H-Indol-3-yl)-N-(l-methoxymethyl-cyclohexylmethyl)-2-methyl-2-[4-(4- nitro-phenyl)-oxazoI-2-ylamino]-propionamide The above compound was synthesized from Intermediate 4a and Intermediate 13 using the same method as used for Example 9. The acid (4a) (203mg, 0.5mmol), HBTU (190mg, 0.5mmol), and DIPEA (87j-tl, 0.5mmol) were stiπed in DMF (10ml) for 5 minutes before adding DIPEA (87μl x 2, l.Ommol) and Intermediate 13 (94mg, 0.5mmol, Scheme 6). After 4 hours the solvent was removed under reduced pressure and residue taken up in EtOAc. The organic layer was washed with brine, saturated NaHCO (x3), brine, dried (MgSO 4 ) and solvent removed under reduced pressure. The residue was heated to 60°C in methanol and product filtered off. Drying under reduced pressure gave the desired product as a yellow crystalline solid (214mg, 78%): MPt: 189-192°C; MS m/e (ES+): 546.49 (M + H, 100%); IR(film): 3285, 2928, 2849, 1637, 1604, 1516, 1453, 1334, 1260, 1108, 1077, 860, 743, 729 cm "1 ; 1HNMR (DMSO-d 6 ): δ= 1.10-1.35 (10H, m), 1.44 (3H, s), 2.91-3.01 (3H, m), 3.06-3.12 (IH, m), 3.07 (3H, s), 3.26-3.31 (IH, m), 3.64 (IH, d, J=14.4 Hz), 6.87-6.93 (2H, m), 7.01 (IH, t, J=7.4 Hz), 7.29-7.37 (3H, m), 7.44 (IH, s), 7.94 (2H, d, J=9.0 Hz), 8.26 (2H, d, J=8.8 Hz), 8.34 (IH, s), 10.84 (IH, s); HPLC A: Rt. 17.07 min, 100/100% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSID 250x4.6mm 5μM, 215 and 254 nm; HPLC B: Rt. 14.35 min, 100/100% purity, 80:20 methanol/Tris buffer at ρH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm. Example 11 (S)-3-(lH-IndoI-3-yl)-2-methyI-2-[4-(4-nitro-phenyl)-oxazol-2-ylamino]- V-(2-oxo- 2-phenyl-ethyl)-propionamide. The above compound was synthesised from Intermediate 4a using the same method as used for Example 9. The acid (4a) (203mg, 0.5mmol), HBTU (190mg, 0.5mmol), and DIPEA (87μl, 0.5mmol) were stirred in DMF (10ml) for 5 minutes before adding DIPEA (87μl, 0.5mmol) and 2-amino-l-phenyl-ethanone (103mg, 0.6mmol). After 4 hours the solvent was removed under reduced pressure and residue taken up in EtOAc, washed with brine, saturated NaHCO 3 (x3), brine, dried (MgSO 4 ) and solvent removed under reduced pressure. The residue was purified by chromatography using NP 20g Mega Bond Elut cartridge and 40% ethyl acetate in heptane as eluent. Evaporation of pure fractions gave the desired product as a yellow amorphous solid (170mg, 65%): MPt: 80-90°C; MS m/e (AP+): 525.83 (16%), 524.44 (NT + H, 100%); TR (film): 3396, 3059, 2983, 2932, 1694, 1628, 1605, 1575, 1514, 1449, 1336, 1284, 1264, 1225, 1181, 1154, 1096, 1072, 1010, 1001, 940, 853, 737 cm "1 ; 1H NMR (DMSO-d δ ): δ= 1.50 (3H, s), 3.39 (IH, d, J=14.7 Hz), 3.64 (IH, d, J=14.6 Hz), 4.53 (IH, d.d, J=18.1 and 5.4 Hz), 4.66 (IH, d.d, J=18.1 and 5.5 Hz), 6.87 (IH, t, J=7.4 Hz), 6.95 (IH, d, J=2.2 Hz), 7.00 (IH, t, J=7.4 Hz), 7.30 (IH, d, J=8.1 Hz), 7.34 (IH, d, J=8.1 Hz), 7.41 (IH, s), 7.50-7.55 (2H, m), 7.62-7.67 (lH,m), 7.94- 7.99 (4H, m), 8.24 (IH, t, J=5.4 Hz), 8.27 (2H, d, J=9.0 Hz), 8.31 (IH, s), 10.86 (IH, s); HPLC A: Rt. 20.83 min, 98.3/99.6% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 25 min at lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm; HPLC B: Rt. 6.82 min, 100/100% purity, 80:20 methanol Tris buffer at ρH9, lmlmin " Prodigy ODS I 250x4.6mm 5μM, 215 and 254 nm. Example 12 (S)-N-[l-(5-Methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl-2-[4-(4-nitro- phenyI)-oxazoI-2-ylamino]-3-phenyl-propionamide The above compound was synthesised from lb and 4b using the same methods as used for Example 9. The acid (4b) (120mg, 0.33mmol), HBTU (124mg, 0.33mmol), and DTPEA (114μl, 0.66mmol), and [l-(5-methoxy-2- pyridy^cyclohexyy-methanamine 1 (86mg, 0.4mmol) were stiπed in DMF (4ml) for 18 hours. Solvent removed under reduced pressure and residue taken up in EtOAc. The organic layer was washed with brine, saturated NaHCO 3 (x3), brine, dried (MgSO ) and solvent removed under reduced pressure. The residue was purified by chromatography using NP silica with 10-80% ethyl acetate in heptane. Pure fractions were evaporated to give the desired compound as a yellow amorphous solid (90mg, 49%): MS m/e (AP+): 570.23 (M + + H, 100%); IR (film): 3363, 2930, 2856, 1658, 1651, 1628, 1574, 1515, 1488, 1334, 1268, 1232, 1073, 1030, 938, 852 cm "1 ; 1H NMR (DMSO-d 6 ): δ= 0.94-1.46 (11H, m), 1.98-2.10 (2H, m), 3.04-3.14 (2H, m), 3.25-3.32 (IH, m), 3.57 (IH, d, J=13.6 Hz), 3.73 (3H, s), 6.95-7.00 (3H, m), 7.10-7.24 (5H, m), 7.44 (IH, s), 7.93 (2H, d, J=8.8 Hz), 8.14 (IH, d, J=2.8 Hz), 8.27 (2H, d, J=9.2 Hz), 8.36 (IH, s); HPLC A: Rt. 5.49 min, 99.76% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 7 min at 1.5 mlmin "1 , Prodigy ODSDI 150x4.6mm 3μM at 40°C, 200-300 nm; HPLC B: Rt. 5.72 min, 99.46% purity, 20-90% CH 3 CN/Tris (ImM) over 7 min at 2mlmin " Prodigy Phenyl-Ethyl, 100x4.6mm 5μM at 30°C, 200-300 nm. Example 13 (S)-2-[4-(4-Cyano-phenyl)-oxazol-2-ylamino]-3-(l-fir-indol-3-yl)-iV-[l-(5-methoxy- pyridin-2-yI)-cyclohexylmethyl]-2-methyl-propionamide The above compound was synthesized from 2a via 6a as outlined in Scheme 2 using methods analogous to those used for Example 9. The acid (6a) (309mg, 0.8mmol), HBTU (303mg, 0.8mmol), DIPEA (140μl, 0.8mmol) were stiπed in DMF (5ml) for 5 minutes before adding DIPEA (140μl, 0.8mmol) and [l-(5-methoxy-2- pyridyl)cyclohexyl]-methanamine (WO 98/07718) (185mg, 0.84mmol). HPLC indicated reaction complete within 1 hour. Solvent removed under reduced pressure and residue taken up in EtOAc. Washed with brine, saturated NaHCO 3 (x3), brine, dried ( gSO 4 ) and solvent removed under reduced pressure. Residue purified by chromatography using RP silica with 65% MeOH in H O. Pure fractions were evaporated to give Example 13 as a white amorphous solid (320mg, 68%): MPt: 105-108°C; MS m/e (ES+): 589.32 (Iv +H, 100%), 590.18 (62%); TR (film): 3355, 2932, 2857, 2225, 1628, 1572, 1521, 1489, 1456, 1328, 1269, 1232, 1096, 1072, 1029, 938, 844, 741 cm "1 ; 1H NMR (CDCI3): δ= 1.20-1.60 (8H, m), 1.70 (3H, s), 1.93-2.03 (2H, m), 3.30-3.52 (4H, m), 3.68 (3H, s), 5.30 (IH, s), 6.89 (IH, d, J=2.4 Hz), 6.94 (IH, d.d, J=8.8 and 2.9 Hz), 7.03-7.09 (2H, m,) 7.14-7.19 (IH, m), 7.20-7.25 (IH, m), 7.33 (IH, d, J=8.1 Hz), 7.46 (IH, d, J=7.8 Hz), 7.50 (IH, s), 7.63 (2H, d, J=8.5 Hz), 7.72 (2H, d, J=8.3 Hz); 8.00 (IH, d, J=2.9 Hz), 8.05 (IH, s); HPLC A: Rt. 11.63 min, 97.7/100% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSHI 250x4.6mm 5/xM, 215 and 254 nm; HPLC B: Rt. 9.20 min, 100/100% purity, 80:20 methanol/Tris buffer at ρH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5j-ιM, 215 and 254 nm. Example 14 (S)-3-(l-H-Indol-3-yl)-N-[l-(5-methoxy-pyrϊdin-2-yl)-cycIohexylmethyl]-2-methyI- 2-(4-phenyl-oxazol-2-ylamino)-propionamide The above compound was synthesised from 2a via 6b as outlined in Scheme 2 using methods analogous to those used for Example 9. The acid (6b) (57mg, 0.148mmol), HBTU (56mg, 0.148mmol), DIPEA (26j-ιl, 0.148mmol) were stiπed in DMF (5ml) for 5 minutes before adding DIPEA (26μl, 0.148mmol) and [l-(5- methoxy-2-pyridyl)cyclohexyl]-methanamine (see WO 98/07718, 34mg, 0.148mmol). HPLC indicated that the reaction was complete within 2 hours. Solvent was removed under reduced pressure and the residue was taken up in EtOAc, washed with brine, sat. NaHCO 3 (x3), brine, dried (MgSO ) and solvent removed under reduced pressure. The residue was purified by chromatography using RP silica with 70% MeOH in H 2 O as eluent. Repurification using NP 8g Biotage cartridge with 45% ethyl acetate in heptane as eluent gave the desired product as a glass (20mg, 24%): MPt: 85-90°C; MS m/e (ES+): 564.06 (MT\ 87%), 564.96 (M + +H, 100%); TR (film): 3289, 2931, 2857, 1627, 1569, 1520, 1488, 1456, 1337, 1267, 1233, 1072, 1072, 1030, 939, 739 cm "1 ; 1H NMR (DMSO-d 6 ): δ= 0.95-1.45 (11H, m), 2.00-2.10 (2H, m), 3.10-3.25 (2H, m), 3.21 (IH, d, J=14.6 Hz), 3.59 (IH, d, J=14.6 Hz), 3.71 (3H, s), 6.84-7.14 (7H, m), 7.24-7.40 (5H, m,), 7.70 (2H, d, J=7.6 Hz), 8.05 (IH, s), 8.15 (IH, d, J=2.9 Hz), 10.82 (IH, s); HPLC A: Rt. 12.01 min, 96.8/95.3% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSIH 250x4.6mm 5 M, 215 and 254 nm; HPLC B: Rt. 17.27 min, 100/100% purity, 80:20 methanol/Tris buffer at pH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm. Example 15 (S)-2-(4-Ethyl-oxazol-2-ylamino)-3-(liϊ-indol-3-yl)-N-[l-(5-methoxy-pyridin-2- yl)-cyclohexylmethyl]-2-methyl-propionamide The above compound was synthesized from 2a via 6c as outlined in Scheme 2 using methods analogous to those used for Example 9. The acid (6c) (188mg, 0.6mmol), HBTU (228mg, 0.6mmol), and DIPEA (105μl, 0.6mmol) were stiπed in DMF (10ml) for 5 minutes before adding DIPEA (105jul, O.δmmol) and [l-(5- methoxy-2-pyridyl)cyclohexyl]-methanamine (see WO 98/07718, 150mg, 0.65mmol). HPLC indicated that the reaction was complete within 4 hours. Solvent was removed under reduced pressure and residue was taken up in EtOAc, washed with brine, sat. NaHCO 3 (x3), brine, dried (MgSO 4 ) and solvent removed under reduced pressure. The residue was purified by chromatography using RP silica with 65% MeOH in H 2 O. The product was repurified using 20g Mega Bond Elut silica cartridge with 45% ethyl acetate in heptane as eluent. Pure fractions were evaporated to give the above compound as a glass (30mg, 10%): MPt: 60-65°C; MS m/e (ES+): 516.24 (M 1" + H, 47%), 517.01 (100%), 538.10 (M 1" + Na, 25%); IR (film): 3272, 3054, 2931, 2856, 1651, 1622, 1596, 1573, 1520, 1489, 1457, 1358, 1268, 1232, 1206, 1131, 1083, 1028, 949, 830, 740 cm "1 ; 1H NMR (DMSO-dg): δ= 1.10-1.50 (8H, m), 1.11 (3H, t, J=7.4 Hz), 1.29 (3H, s), 2.05-2.15 (2H, m), 2.28-2.34 (2H, m), 3.08-3.18 (3H, m), 3.48 (IH, d, J=14.4 Hz), 3.79 (3H, s), 6.80-6.90 (3H, m), 6.97-7.04 " (2H, m,), 7.10-7.20 (3H, m), 7.27-7.30 (2H, m), 8.17 (IH, d, J=2.9 Hz), 10.80 (IH, s); LCMS: Rt. 1.36 min, 100% purity, 5-100% CH 3 CN in H 2 O (+0.1% Formic acid) over 2 min at 4 mlmin "1 , Prodigy ODSID 50x4.6mm 5μM, 215 nm, MS m e (ES+) 515.95 (100%); HPLC B: Rt. 12.29 min, 100/100% purity, 80:20 methanol/Tris buffer at pH9, 1 mlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm; Example 16 (S)-3-(l-H r -Indol-3-yl)-iV-[l-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl- 2-[4-(4-nitro-phenyl)-thiazol-2-ylamino]-propionamide The above compound was synthesized using a one-pot procedure as outlined in Scheme 3. A suspension of H-S-oMeTrp-OH (Intermediate 7) (437mg, 2mmol), 2-chloro-4-(4-nitro-phenyl)-thiazole (see Peet, Norton P.; Sunder, Shyam. Reinvestigation of the reported preparation of 3-(4-nitrophenyl)thiazolo[2,3- c][l,2,4]triazeρines, J. Heterocycl. Chem. (1986), 23(2), 593-5; 481mg, 2mmol), copper (I) iodide (38mg, 0.2mmol), and K 2 CO 3 (415mg, 3mmol) in DMF (12ml) under nitrogen was heated to 130°C for 12 hours. The reaction mixture was cooled to ambient temperature before adding HBTU (759mg, 2mmol) and [l-(5-methoxy-2- pyridyl)cyclohexyl]-methanamine (see WO 98/07718; 441mg, 2mmol). The mixture was stiπed overnight, then concentrated in vacuo, after which the residue was partitioned between water (20ml) and dichloromethane (30ml). The organic phase was separated and filtered through silica (3x12cm) using 500ml of dichloromethane and then 500ml of dichloromethane-ether (1:1). Fractions containing product were concentrated under reduced pressure. The residue was absorbed onto 3.5g silica and purified by chromatography (3x1 lcm) using heptane-ethyl acetate (1:1.1). The product was repurified using RP chromatography (Biotage KP-C18-HS Flash 12M, ISml.min "1 , 60-100% methanol in water). Concentration under reduced pressure gave the desired compound as a pale yellow amorphous solid (27mg, 2%): MPt: 110-114°C; MS m/e (AP+): 624.88 (Jv , 100%), 625.70 (M* + H, 52%); IR (film): 3385, 3279, 2931, 2855, 1654, 1595, 1542, 1509, 1456, 1341, 1268, 1231, 1108, 1058, 908, 844, 731 cm "1 ; 1H NMR (CDC1 3 ): δ= 1.15-1.55 (8H, m), 1.71 (3H, s), 1.90-2.00 (2H, m), 3.16-3.42 (2H, m), 3.46 (IH, d, J=14.9 Hz), 3.60 (IH, d, J=14.6 Hz), 3.70 (3H, s), 5.51 (IH, s), 6.89-6.93 (3H, m), 6.98 (IH, d, J=8.8 Hz), 7.05-7.10 (IH, m), 7.15-7.25 (2H, m), 7.34 (IH, d, J=8.3 Hz), 7.47 (IH, d, J=7.8 Hz), 7.90 (2H, d, J=9.0 Hz), 7.98 (IH, d, J=2.9 Hz), 9.05 (IH, s), 8.21 (2H, d, J=8.8 Hz); HPLC A: Rt. 12.30min, 99.4% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin Prodigy ODSDI 250x4.6mm 5μM, 200-300 nm; HPLC B: Rt. 15.38min, 99.5% purity, 80:20 methanol/Tris buffer at ρH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 200-300 nm. Example 17 (S)-2-(Benzooxazol-2-ylamino)-3-(lJΪ-indoI-3-yl)-2-methyl-/V-(l-pyridin-2-yI- cyclohexylmethyl)-propionamide 1. The following reagents were combined in the order that they are listed: Intermediate 7 (545mg, 2.5mmol), 2-chlorobenzoxazole (384mg, 2.5mmol), potassium carbonate (346mg, 2.5mmol), benzyltriethylammonium chloride (TEBA, 114mg, 0.5mmol), triethylamine (1.04ml, 7.5mmol), DMF (12.5ml), deoxygenated water (1.25ml), copper (I) iodide (24mg, 0.125mmol), trans-dichlorobis(tri-o-tolyl- phosphine)palladium(D) (99mg, 0.125mmol). After heating at 100°C under nitrogen for 24 hours the DMF was removed under reduced pressure. The residue was taken up in ethyl acetate/water and the aqueous phase was acidified to pH 6-6.5 using citric acid. The aqueous phase was extracted with three further portions of ethyl acetate. The combined organic layers were dried (MgSO ) and solvent was removed under reduced pressure. The residue was purified by chromatography using lOg NP silica with 0-100%) ethyl acetate in heptane. Crystallisation from dichloromethane gave (S)- 2-(benzooxazol-2-ylanrino)-3-(lH-indol-3-yl)-2-methyl-propionic acid (245mg, 29%). MS m/e (ES+) 335.97 OVT + Η, 100%), 336.69 (85%). 2. The propionic acid (234mg, 0.7mmol), ΗBTU (265mg, 0.7mmol), and DIPEA (122j-.l, 0.7mmol) were stiπed in DMF (10ml) for 5 minutes before adding DIPEA (122μl, 0.7mmol) and [l-(2- ρyridyl)cyclohexyl]methylamine (WO 98/07718; 140mg, 0.74mmol). After 4 hours at ambient temperature the solvent was removed under reduced pressure. The residue was purified by chromatography using NP silica with 50% ethyl acetate in heptane as eluent. Pure fractions were evaporated to give the desired compound as fine needles (44mg, 3%): MPt: 198-200°C; MS m/e (ES 4 ): 508.59 (100%, Ivf+ H), 509.92 (10%); TR (film): 3381, 3222, 3048, 2929, 2856, 1635, 1581, 1552, 1519, 1458, 1353, 1241, 1096, 742 cm "1 ; 1H NMR (CDC1 3 ): δ = 1.20-1.60 (8H, m), 1.76 (3H, s), 1.95-2.05 (2H, m), 3.34 (IH, d.d, J=13.2 and 4.9 Hz), 3.45 (IH, d.d, J 3.2 and 5.6 Hz), 3.50 (2H, s), 5.67 (IH, s), 6.78-6.82 (IH, m), 6.89 (IH, d, J=2.2 Hz), 6.99-7.35 (10H, m), 7.43 (IH, d, J=8.1 Hz), 8.01 (IH, s), 8.24 (IH, d, J=4.6 Hz); HPLC A: Rt. 10.54 min, 100/100% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSHI 250x4.6mm 5 M, 215 and 254 nm; HPLC B: Rt. 10.67 min, 100/100% purity, 80:20 methanol/Tris buffer at ρH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm; Example 18 (S)-3-(l^-Indol-3-yl)-2-methyl-2-φyridin-4-ylamino)-iV-(l-pyridin-2-yl- cyclohexylmethyl)-propionamide The above compound was prepared on the same scale and using an analogous method as used for Example 17. 1. The method of Example 17 was ' repeated except that 4-bromopyridine hydrochloride (486mg, 2.5mmol) was used. 2. The acid from step 1 (30mg, O.lmmol), HBTU (38mg, O.lmmol), and DIPEA (18jιtl, O.lmmol) were stiπed in DMF (10ml) for 5 minutes before adding DIPEA (18/d, O.lmmol) and [l-(2- pyridyl)cyclohexyl]methylamine (WO 98/07718; 19mg, O.lmmol). After 2 hours at ambient temperature the solvent was removed under reduced pressure. The residue was taken up in ethyl acetate and washed with sodium bicarbonate solution (x2), brine, and dried (MgSO 4 ). The solvent was removed under reduced pressure. The crude product was purified by chromatography using lOg ISCO Redisep cartridge with ethyl acetate as eluent. Repurification using 20g RP-C18 with 70% methanol in water and subsequent evaporation gave the desired product in crystalline form (6mg, 13%): MPt: 180-195°C; MS m/e (AP + ): 468.12 (M* + H, 100%), 469.59 (M 1" + 2H, 20%); MS m/e (AP-): 467.56 (M, 45%), 466.60 (M - H, 100%), 465.64 (M - 2H, 88%); TR (film): 3316, 2930,1651, 1602, 1515, 1430, 1106, 997, 816, 741 cm "1 ; NMR (CDCl 3 ):δ = 1.25-1.70 (8H, m), 1.46 (3H, s), 2.00-2.10 (2H, m), 3.27 (IH, d, J=14.9 Hz), 3.30-3.48 (2H, m), 3.36 (IH, d, J=14.9 Hz), 4.43 (IH, s), 6.22 (2H, d, J=5.6 Hz), 6.85 (IH, d, J=2.0 Hz), 6.89-6.93 (IH, m), 7.11-7.37 (5H, m), 7.46-7.54 (2H, m), 8.08-8.13 (4H, m); HPLC A: Rt. 7.21 min, 96.1/96.5% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSID 250x4.6mm 5μM, 215 and 254 nm; HPLC B: Rt. 6.02 min, 99.1/100% purity, 80:20 methanol/Tris buffer at pH9, lmlmin "1 , Prodigy ODSID 250x4.6mm 5μM, 215 and 254 nm. Example 19 (S)-3-(l J ff-Indol-3-yI)-2-(isoquinolin-4-yIariiino)-2-methyl-N-(l-pyridin-2-yl- cyclohexylmethyl)-propionamide Example 19 was prepared on the same scale and using an analogous method as used for Example 17. 1. The method of Example 17 was followed except that 4-bromoisoquinoline (520mg, 2.5mmol) was used. 2. The acid from step 1 (40mg, 0.12mmol), HBTU (46mg, 0.12mmol), and DIPEA (21μl, 0.12mmol) were stiπed in DMF (10ml) for 5 minutes before adding DIPEA (21μl, 0.12mmol) and [l-(2- pyridyl)cyclohexyl]methylamine (WO 98/07718; 23mg, 0.12mmol). After 2 hours at ambient temperature the solvent was removed under reduced pressure. The residue was taken up in ethyl acetate and washed with sodium bicarbonate solution (x2) and brine and dried (MgSO 4 ). The solvent was removed under reduced pressure. The crude product was purified by chromatography using lOg ISCO Redisep cartridge with 80% ethyl acetate in heptane as eluent. Repurification using 20g RP-C18 with 70% methanol in water and subsequent evaporation gave the desired product as a glass (9mg, 14%): MPt: 98-101°C; MS m/e (AP + ): 518.28 (100%, Iv + H), 517.40 50%); MS m/e (AP-): 516.53 (75%, M " ), 515.63 (100%, M " - H); TR (film): 3385, 3278, 3052, 2927, 2849, 1651, 1585, 1520, 1455, 1403, 1343, 781,740 cm "1 ; NMR (CDC1 3 ): δ= 1.20-1.65 (11H, m), 1.93-2.10 (2H, m), 3.35 (IH, d, J=14.6Hz), 3.39-3.52 (2H, m), 3.48 (IH, d, J=14.9 Hz), 4.62 (IH, s), 6.55-6.59 (IH, m), 6.90 (IH, d, J=2.0 Hz), 7.00 (IH, d, J=8.ϊ Hz), 7.17-7.28 (4H, m), 7.37-7.55 (4H, m), 7.62 (IH, s), 7.70 (IH, d, J=7.6 Hz), 7.74-7.76 (IH, m), 7.87 (IH, d, J=8.1 Hz), 8.15 (IH, s), 8.63 (IH, s) HPLC A: Rt. 7.52 min, 100/100% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSID 250x4.6mm 5μM, 215 and 254 nm; HPLC B: Rt. 8.33 min, 99.7/100% purity, 80:20 methanol Tris buffer at pH9, lmlmin "1 , Prodigy ODSID 250x4.6mm 5 M, 215 and 254 nm; Example 20 (S)-3-(l J H-Indol-3-yl)-2-methyl-N-(l-pyridin-2-yl-cyclohexylmethyl)-2- (pyrimidin-5-ylamino)-propionamide The above compound was prepared on the same scale and using an analogous method as used for Example 17. 1. The method of Example 17 was followed except that 5-bromopyrimidine (397mg, 2.5mmol) was used. 2. The acid from step 1 (150mg, 0.5mmol), HBTU (190mg, 0.5mmol), and DIPEA (87μl, 0.5mmol) were stiπed in DMF (10ml) for 5 minutes before adding DIPEA (87μl, 0.5mmol) and [l-(2-ρyridyl)cyclohexyl]methylamine (WO 98/07718; 95mg, 0.5mmol). After 2 hours at ambient temperature the solvent was removed under reduced pressure. The residue was taken up in ethyl acetate and washed with sodium bicarbonate solution (x2) and brine and dried (MgSO 4 ). The solvent was removed under reduced pressure. The crade product was purified by chromatography using lOg ISCO Redisep cartridge with 90% ethyl acetate in heptane as eluent. Removal of the solvent under reduced pressure gave the desired product as a foam (135mg, 58%): MPt: 95-98°C; MS m/e (AP 4 ): 470.60 (25%), 469.58 (M 4 +H, 100%), 468.77 (M + , 92%); MS m/e (AP " ): 467.60 (M " - H, 70%), 466.85 (100%); IR (film): 3291, 3052, 2931, 2857, 1651, 1575, 1519, 1470, 1455, 1427, 1357, 1306, 1265, 1237, 1194, 1156, 1106, 1010, 848, 788, 739 cm "1 ; NMR (CDC1 3 ): δ= 1.20-1.65 (8H, m), 1.48 (3H, s), 2.00-2.10 (2H, m), 3.24- 3.48 (4H, m), 4.14 (IH, s), 6.88-6.92 (2H, m), 7.13-7.24 (3H, m), 7.37 (IH, d, J=8.1 Hz), 7.48-7.55 (3H, m), 7.86 (2H, s), 8.08-8.10 (IH, m), 8.16 (IH, s), 8.57 (IH, s); HPLC A: Rt. 8.94 min, 99.3/99.4% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm; HPLC B: Rt. 5.76 min, 95.1/98.7% purity, 80:20 methanol Tris buffer at pH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm. Example 21 (S)-2-(Biphenyl-2-yIamino)-3-(l-H-indol-3-yl)-2-methyI-iV-(l-pyridiιι-2-yl- cycIohexylmethyl)-propionamide The above compound was prepared on the same scale and using an analogous method as used for Example 17. 1. The method of Example 18 except for the use of 2-bromo biphenyl (583mg, 2.5mmols). 2. The acid from step 1 (350mg, 0.95mmol), HBTU (400mg, lmmol), NEt 3 (0.5ml, 3.5mmol), and l-(2- pyridyl)cyclohexyl]methylamine (WO 98/07718; 200mg, lmmol) were stiπed in DMF (15ml). After 1 hour at ambient temperature the reaction mixture was diluted with ethyl acetate (100ml), washed with sodium bicarbonate solution (x2) and dried (MgSO 4 ). The solvent was removed under reduced pressure. The crude product was purified by chromatography using 0-50% ethyl acetate in heptane and then 0-30% dichloromethane in ether as eluent. Removal of the solvent under reduced pressure gave the desired product as a foam (98mg, 19% for step 2): MS m/e (AP ): 565 (Iv + Na, 100%), 564 (80%), 542 ( X, 30%) IR (KBr disc): 3404, 2928, 2855, 1650, 1584, 1508, 1489, 1458, 1432 cm "1 ; NMR (DMSO-de): δ = 1.10-1.52 (8H, m), 1.27 (3H, s), 1.95-2.05 (2H, m), 2.95 (IH, d, J=14.4 Hz), 3.02-3.08 (IH, m), 3.08 (IH, d, J=14.6 Hz), 3.28-3.34 (IH, m), 4.36 (IH, s), 6.37 (IH, d, J=8 Hz), 6.49 (IH, d, J=2.2 Hz), 6.71-6.75 (IH, m), 6.82-6.86 (IH, m), 6.95-7.43 (13H, m), 7.52-7.57 (IH, m), 8.33 (IH, d, J=3.7 Hz), 10.81 (IH, s); HPLC A: Rt. 12.65min, 99.65% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 200-300 nm; HPLC B: Rt. 33.05min, 99.89% purity, 80:20 methanol/Tris buffer at pH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 200-300 nm. Example 22 (S)-3-(lH-Indol-3-yl)-2-methyl-iV-(l-pyridin-2-yl-cyclohexylmethyl)-2-»ι- tolylamino-propionamide The above compound was prepared using a one-pot procedure analogous to the method used for Example 16. The synthesis was carried out on lmmol scale using l-bromo-3-methyl-benzene (171mg, lmmol). The crude product was purified by chromatography using 25g NP silica with 25% ethyl acetate in heptane as eluent. Removal of the solvent under reduced pressure gave the desired compound as a glass (260mg, 54%): MPt: 70-75°C; MS m/e (AP ): 481.33 (100%, M + + H), 482.37 (40%); IR (film): 3385, 3291, 3049, 2929, 2857, 1652, 1607, 1590, 1513, 1456, 1431, 1341, 1302, 1264, 1237, 1177, 1155, 1104, 1010, 774, 741 cm "1 ; NMR (DMSO-de): δ= 1.08-1.50 (8H, m), 1.19 (3H, s), 2.00-2.10 (2H, m), 2.16 (3H, s), 3.03 (IH, d.d, J=12.9 and 5.1 Hz), 3.10 (IH, d, J=14.7Hz), 3.22 (IH, d, J=14.6Hz), 3.24-3.30 (IH, m), 5.43 (IH, s), 6.29 (IH, s), 6.30 and 6.44 (each IH, each d, J=7.6 Hz), 6.87-7.07 (6H, m), 7.15-7.19 (IH, m), 7.29 (IH, d, J=8.0 Hz), 7.33 (IH, d, J=7.8 Hz), 7.48-7.54 (IH, m), 8.31-8.33 (IH, m), 10.81 (IH, s); HPLC A: Rt. 11.04 min, 98.3% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 200-300 nm; HPLC B: Rt. 16.87 min, 99.5% purity, 80:20 methanol/Tris buffer at pH9, lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 200-300 nm. Example 23 (S)-3-(l -Indol-3-yl)-2-methyl-2-(6-phenyl-pyridin-2-ylamino)-N-(l-pyridin-2- yl-cyclohexylmethyl)-propionamide The above compound was prepared using a one-pot procedure analogous to the method used for Example 16. The synthesis was carried out on 0.4mmol scale using 2-bromo-6-phenyl-pyridine (95mg, 0.4 mmol). The crude product was purified by chromatography using 25g NP silica with 55% ethyl acetate in heptane as eluent. Removal of the solvent under reduced pressure gave the desired product as a foam (260mg, 54%): MS m/e (AP + ) 544.31 (100%, M + H), 545.35 (35%); MS m/e (AP " ) 542.29 (100%, M " - H), 543.31 (M " , 40%); JR (film): 3407, 3276, 3056, 2930, 2857, 1651, 1595, 1576, 1519, 1486, 1467, 1455, 1439, 1339, 1264, 1180, 1157, 1105, 1028, 1009, 991, 804, 763, 739 cm "1 ; NMR (CDC1 3 ) δ= 1.03-1.60 (8H, m), 1.53 (3H, s), 1.90-2.03 (2H, m), 3.32- 3.45 (3H, m), 3.65 (IH, d, JM14.6Hz), 4.67 (IH, s), 6.13 (IH, d, J=8.3 Hz), 6.77-7.50 (14H, m), 7.97 (2H, d, J=7.1 Hz), 8.02 (IH, s), 8.23-8.25 (IH, m); HPLC A: Rt. 4.21 min, 96.8% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 7 min at l.Smlmin "1 , Prodigy ODSDI 150x4.6mm 5μM, 200-300 nm. Example 24 (R)-3-Phenyl-2-phenylamino-N-[l-pyridin-2-yl-cyclohexylmethyl)-propionamide The above compound was synthesised as a two step process from Intermediate 8 as shown in Scheme 4. 1. To a solution of Intermediate 8 (0.5g, 3mmol) and bromobenzene (0.35ml, 3.3mmol) in DMA (5ml) under nitrogen was added potassium carbonate (0.6g, 4.3mmol) and copper (I) iodide (50mg, 0.26mmol) after which the mixture was heated to 90°C for 1.5 hours. Solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with 5% methanol in dichloromethane. Removal of solvent under reduced pressure gave (R)-3-phenyl-2- phenylamino-propionic acid as an oil (0.41 g, 56%): MS m/e (AP 4 ): 242 (M + + H, 100%). 2. The acid from step 1 (0.40g, 1.66mmol), HBTU (0.6g, 1.8mmol), and NEt 3 (0.5ml, 3.5mmol), and l-(2-ρyridyl)cyclohexyl]methylamine (WO 98/07718; 0.35mg, 1.8mmol) were stiπed in DMF (15ml). After 1 hour at ambient temperature the reaction mixture was diluted with ethyl acetate (100ml), washed with sodium bicarbonate solution (x2) and dried (MgSO 4 ). The solvent was removed under reduced pressure. The crade product was purified by chromatography using 50% ethyl acetate in heptane and then RP C18 silica with 70% methanol in water as eluent. Removal of the solvent under reduced pressure gave the desired product as a white amorphous solid (0.15g, 22%): MPt: 113-115°C; MS m/e (AP 4 ): 414.22 (M 4" + H, 100%); IR (KBr disc): 3300, 2931, 2858, 1649, 1605, 1589, 1523, 1498, 1432, 1318, 748 cm "1 ; NMR (CDC1 3 ): δ = 1.20-1.70 (8H, m), 1. 90-2.15 (2H, m), 2.91 (IH, d.d, J=14.2 and 8.8 Hz), 3.27 (IH, d.d, J=14.2 and 4.4 Hz), 3.38 (IH, d.d, J=13.2 and 5.5 Hz), 3.48 (IH, d.d, J=13.2 and 6.1 Hz), 3.80 (IH, d, J=3.4 Hz), 3.88-3.93 (IH, m), 6.44 (2H, d, J=7.8 Hz), 6.74 (IH, t, J=11.3 Hz), 6.90-7.45 (HH,m), 8.28 (IH, d, J=3.6 Hz); HPLC A: Rt. 4.51 min, 100% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 10 min at 1.5 mlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 200-300 nm; HPLC B: Rt. 13.15 min, 99.14% purity, 80:20 methanoi/Tris buffer at pH9, lmlmin "1 , Prodigy ODS T 250x4.6mm 5μM/200-300 nm. Example 25 (S)-3-(l-H-Indol-3-yl)-2-methyl-2-phenylethylamino-N-(l-pyridin-2-yl- cyclohexylmethyl)-propionamide The above compound was prepared as shown in Scheme 5 via Intermediate 10. 1. To a stiπed solution of H-(S)-oMeTrp-OH (7) (lOg, 46mmol) and di-t-butyl- dicarbonate (lOg, 46mmol) in dioxan (100ml) was added water (20ml) and potassium carbonate (lOg, 74mmol). After 4 hours the reaction mixture was acidified with 2N hydrochloric acid (150ml) and product was extracted with ethyl acetate (2 x 200ml). The combined organic phases were dried (MgSO 4 ) and evaporated under reduced pressure. The residue was purified by flash chromatography using ethyl acetate as eluent. Removal of solvent under reduced pressure gave Boc-(S)-oMeTrp-OH as an orange oil (14.5g, 99%). To a stiπed solution of Boc-(S)-oMeTrp-OH (7g, 22rnmol) in DMF (100ml) was added HBTU (8.0g, 22mmol), triethylamine (5ml, 35mmol), and [l-(2-ρyridyl)cyclohexyl]methylamine (WO 98/07718; 4.2g, 22mmol). After 1 hour the reaction mixture was diluted with ethyl acetate (300ml), washed with 2N hydrochloric acid (2 x 200ml), dried (MgSO 4 ) and evaporated under reduced pressure at 60°C. The residue was purified by flash chromatography. Elution with 5% methanol in dichloromethane and subsequent removal of solvent under reduced pressure gave intermediate 9 as yellow oil (8.3g, 77%): MS m/e (AP+): 491 (M + H, 100%), " 513 (M 4 + Na, 20%); IR (film): 3339, 2929, 2858, 1704, 1659, 1651, 1589, 1519, 1487, 1366, 1249, 1164,1070,908,737 cm "1 ; NMR (CDC1 3 ): δ = 1.20-1.70 (20H, m), 2.00-2.12 (2H, m), 3.25-3.50 (4H, m), 5.05-5.20 (IH, br.s), 6.92 (IH, d, J=2.0 Hz), 7.02-7.32 (6H, m), 7.51 (IH, d, J=8.0 Hz), 7.59-7.64 (IH, m), 8.03 (IH, s), 8.48 (IH, d, J=4 Hz). 2. To a stiπed solution of Intermediate 9 (8.2g, 16.5mmol) in dichloromethane (100ml) was added trifluoroacetic acid (3.0ml, 39mmol). After 18 hours the solvent was removed under reduced pressure at 60°C. The residue was treated cautiously with saturated sodium carbonate solution (200ml) before extracting with ethyl acetate (3 x 200ml). The combined organic phases were dried (MgSO 4 ) and evaporated under reduced pressure at 60°C. The residue was purified by flash chromatography. Elution with 0-5% methanol in dichloromethane and subsequent removal of solvent under reduced pressure gave Intermediate 10 as white foam (4.85g, 75%): MPt: 65-68°C; MS m/e (AP+): 391 (M 4 + H, 100%); IR (KBr disc): 3367, 2926, 2855, 1648, 1589, 1569, 1522, 1455, 1430, 1366, 1341, 1234, 842, 784, 742 cm "1 ; NMR (CDC1 3 ): δ = 1.20-1.80 (13H, m), 1.98-2.20 (2H, ), 2.83 (IH, d, J=14.2 Hz), 3.33 (IH, d, J=14.2 Hz), 3.38 (2H, d, J=5.6 Hz), 6.98-7.20 (6H, m), 7.50- 7.75 (3H, m), 8.05-8.15 (IH, s), 8.49-8.51 (IH, m); 3. To a stirred solution of Intermediate 10 (293mg, 0.75mmol) and phenacetaldehyde (90mg, 0.75mmol) in 1,2-dichloroethane (20ml) was added solid sodium triacetoxyborohydride (316mg, 1.5mmol). After stirring overnight, saturated sodium bicarbonate solution was added - effervescence was observed. The aqueous phase was extracted with dichloromethane. The combined organic phases were dried (MgSO 4 ) and solvent was removed under reduced pressure. The residue was purified by chromatography using 20g RP-C18 with 0-50% methanol in water followed by 20g NP silica with 45% ethyl acetate in heptane. Removal of solvent under reduced pressure gave the desired compound as a glass (60mg, 16%): MS m/e (ES 4 ): 496.56 (28%), 495.5 (52%, M + + H), 364.43 (22%), 269.34 (51%), 268.90 (88%), 248.37 (100%); IR (fihn): 3274, 3058, 2928, 2856, 1651, 1588, 1568, 1519, 1469, 1454, 1431, 1355, 1263, 1236, 1155, 1117, 1053, 1030, 1009, 992, 930, 782, 742 cm "1 ; 1H NMR (CDC1 3 ): δ - 1.20-1.65 (11H, m), 2.00-2.20 (2H, m), 2.40-2.75 (4H, m), 2.94 and 3.05 (each IH, each d, J=14.4 Hz), 3.41 (2H, d, J=6.1 Hz), 6.74 (IH, d, J=2.2 Hz), 7.04-7.25 (9H, m), 7.32 (IH, d, J=7.8 Hz), 7.55-7.60 (3H, m), 7.90 (IH, s), 8.55-8.58 (IH, m); HPLC A: Rt. 8.52 min, 99.0/98.6% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin 1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm; HPLC B: Rt. 23.84 min, 99.6/100% purity, 80:20 methanol/Tris buffer at pH9, lmlmin "1 , Prodigy ODSID 250x4.6mm 5μM, 215 and 254 nm. Example 26 (S)-2-[(Benzofuran-2-ylmethyl)-amino]-3-(lJϊ-indol-3-yl)-2-methyl-N-(l-pyridin- 2-yl-cyclohexylmethyl)-propionamide The above compound was prepared as shown in Scheme 5 via Intermediate 10. To a stiπed solution of Intermediate 10 (150mg, 0.38mmol) and benzofuran-2- carbaldehyde (56mg, 0.38mmol) in 1,2-dichloroethane (5ml) was added sohd sodium triacetoxyborohydride (162mg, 0.77mmol). After stirring at room temperature for 48 hours saturated sodium bicarbonate solution was added - effervescence was observed. The aqueous phase was extracted with ethyl acetate. The combined organic phases were dried (MgSO 4 ) and solvent removed under reduced pressure. The residue was purified by chromatography using 60% ethyl acetate in heptane. Removal of solvent under reduced pressure gave the desired product as an amorphous white solid (29mg, 15%): MS me (ES): 521.08 (M + H, 100%), 391.06 (50%); IR (film): 3268, 3056, 2930, 2856, 1656, 1588, 1569, 1519, 1469, 1454, 1431, 1355, 1342, 1255, 1171, 1105, 1052, 1009, 909, 788, 740 cm "1 ; 1HNMR (CDC1 3 ): δ = 1.20-2.20 (14H, m), 3.08 (IH, d, J=14.4 Hz), 3.14 (IH, d, J=14.8 Hz), 3.45-3.49 (2H, m), 3.66 (IH, d, J=14.4 Hz), 3.76 (IH, d, J=14.8 Hz), 6.33 (IH, s), 6.84-6.88 (IH, m), 7.00-7.65 (12H, m), 8.32 (IH, s), 8.39 (IH, d, J=4.0 Hz); HPLC A: Rt. 8.86 min, 99.7/99.1% purity, 20-100% CH 3 CN in H 2 O (+0.1%TFA) over 15 min at lmlmin "1 , Prodigy ODSDI 250x4.6mm 5μM, 215 and 254 nm. Example 27 (S)-3-(l-fir-Indol-3-yl)-2-methyI-2-(4-nitro-benzylamino)-iV-(l-pyridin-2-yl- cyclohexylmethyl)-propionamide The above compound was prepared as shown in Scheme 5 via Intermediate 10. To a stirred solution of Intermediate 10 (150mg, O.38mmol) and 4- nitrobenzaldehyde (58mg, 0.38mmol) in 1,2-dichloroethane (5ml) was added solid sodium triacetoxyborohydride (114mg, 0.54mmol). After stirring at room temperature for 24 hours saturated sodium bicarbonate solution was added - effervescence was observed. The aqueous phase was extracted with ethyl acetate. The combined organic phases were dried (MgSO 4 ) and solvent removed under reduced pressure. The residue was purified by chromatography using 60% ethyl acetate in heptane. Repurifcation using RP silica with 45% methanol in water (+ 1% acetic acid) gave pure product. The pure fractions were combined, basified (sodium carbonate), and extracted with ethyl acetate. Removal of solvent under reduced pressure gave the desired compound as a glass (10.5mg, 5%): MPt: 58-60°C; MS m/e (ES 4 ): 526.15 (M 4 + H, 100%), 527.14 (33%); IR (film): 3365, 2924, 2856, 1652, 1513, 1429, 1346, 1257, 1048 cm "1 ; 1H NMR (DMSO- ): δ = 1.10-1.55 (8H, m), 1.19 (3H, s), 1.88-2.08 (2H, m), 2.25- 2.30 (IH, m), 2.95-3.02 (2H, m), 3.10-3.20 (IH, m), 3.17-3.27 (IH, m), 3.50-3.80 (2H, m), 6.93-7.63 (11H, m), 8.12 (2H, d, J=8.8 Hz), 8.42 (IH, d, J=3.6 Hz), 10.86 (lH, s). Example 28 BBj and BB2 Binding Assays In the following experiments, measurement of BBj and BB2 binding was as follows. CHO-K1 cells stably expressing cloned human NMB (for (BB^ assay) and GRP receptors (for BB2 assay) were routinely grown in Ham's F12 culture medium supplemented with 10% foetal calf serum and 2 mM glutamine. For binding experiments, cells were harvested by trypsinization, and stored frozen at -70°C in Ham's F12 culture medium containing 5% DMSO until required. On the day of use, cells were thawed rapidly, diluted with an excess of culture medium, and centrifuged for 5 minutes at 2000 g. Cells were resuspended in 50 mM Tris-HCl assay buffer (pH 7.4 at 21°C, containing 0.02% BSA, 40μg/mL bacitracin, 2μg/mL chymostatin, 4μg/mL leupeptin, and 2μM phosphoramidon), counted, and polytronned (setting 5, 10 sec) before centrifuging for 10 minutes at 28,000 g. The final pellet was resuspended in assay buffer to a final cell concentration of 1.5 x lONmL. For binding assays, 200μL aliquots of membranes were incubated with (<0.1 nM) in the presence and absence of test compounds (final assay volume 250μL) for 60 minutes and 90 minutes for NMB and GRP receptors, respectively. Nonspecific binding was defined by lμM bombesin. Assays were terminated by rapid filtration under vacuum onto Whatman GF/C filters presoaked in 0.2% PEI for >2 hours, and washed 50 mM Tris-HCl (pH 6.9 at 21 °C; 6 x 1 mL). Radioactivity bound was determined using a gamma counter. All competition data was analysed using nonlinear regression utilizing iterative curve-plotting procedures in Prism ® (GraphPad Software Inc., San Diego, USA). IC 50 values were coπected to K. values using the Cheng-Prusoff equation (Cheng Y., Prusoff W. H., Biochem. Pharmacol. 22: 3099-3108, 1973). The results obtained are listed in Table 1. Table 1 : Human NMB and GRP receptor binding affinities Example 29 Effect of (S)-3-(l J H-Indol-3-yl)-N-[l-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]- 2-methyl-2-[4-(4-nitro-phenyl)-oxazol-2-ylamino]-propionamide (Compound (2)) in PEG200 on female rat sexual proceptivity Ovariectomised adult female Sprague Dawley rats (180-200g, from Charles River) were housed in groups of 6 in a reversed lighting system of 12h lightidark (lights off 7.00-19.00h). Two weeks after ovariectomy they were used for sexual activity tests. Animals were adapted to the apparatus (in the absence of stimuli animals) for lOmin on 2 consecutive days prior to testing. The experiments started at least 5h into the dark period. Tests were carried out in a circular arena of 90cm diameter, suπounded by a 30cm high wall. Two small cages with wire-mesh front (15x15cm) are fixed into the wall such that the front of the cage is "flush" with the wall and the 2 cages are opposite each other. They contain two stimuli animals: an intact sexually experienced male and a receptive female (ovariectomised, primed with 5μg oestradiol benzoate dissolved in com oil and injected subcutaneously 48 hours before the test and with 0.5 mg of progesterone four hours before the test). Sexually naive test and control animals were used. Forty eight hours before the tests, both the test and control ammals were primed with 5μg oestradiol benzoate. Test animals were treated with the above compound (30-lOOmg kg) which was dissolved in PEG 200 vehicle and administered orally in a lml/kg volume lh before each test. For animals used as positive controls, progesterone (0.5mg/0.1ml) was dissolved in com oil and administered subcutaneously (s.c), 4h before the test. Test and control animals were introduced one at a time for 10 minute periods into the arena. During the lOmin test, the time that the test or positive control animal spent investigating each stimulus animal was noted. The arena was thoroughly cleaned between animals. The position of the male/female stimuli boxes was randomised between animals, in order to avoid place preference. The difference in the percentage of time spent investigating male minus female was calculated, out of the total time spent investigating stimuli animals. It was found (see Figure 19) that the above compound dose-dependently (30- 100) increased the percentage of time spent investigating the male stimulus, with a MED of lOOmg/kg (see below). The effect of this dose was similar to the effect of progesterone (maximal). (*P<0.05, **P<0.01 Kruskal-Wallis followed by Mann- Whitney test, vs vehicle). Example 30 Effect of Compound (2) in methyl cellulose on female rat sexual proceptivity. Example 31 was repeated except that the above compound (3-30 mg kg) was dissolved in 0.5% methyl cellulose and was administered p.o. in a dosing volume of 3ml kg lh before tests. Progesterone, (0.5mg/0.1ml) was dissolved in com oil and administered s.c, 4h before test, as a positive control. The above compound dose-dependently (3-30mg/kg) increased the percentage of time spent investigating the male stimulus, with a MED of lOmg/kg. This represents a 10-fold increase in potency compared to the oral results obtained in the PEG200 vehicle (MED=100mg/kg). The results are shown in Figure 20 in which bars represent percentage of time spent investigating male, minus the percentage of time spent investigating the female stimuh±SEM, (n=6-9 per group). *P<0.05, **P<0.01 vs vehicle (One-way ANONA followed by Dunnett's test vs vehicle group). Example 31 Effect of Compound (2) in PEG 200 on female rat sexual receptivity. Ovariectomised adult female Sprague Dawley rats (180-200g, from Charles River) were housed in groups of 6 in a reversed lighting system of 12h light:dark (lights off 7.00-19.00h). Two weeks after ovariectomy they were used for sexual activity tests. The experiments started at least 5h into the dark period. The above compound was dissolved in PEG200 vehicle and administered orally. Quinelorane dihydrochloride (LY 163,502, 6.25μg/kg) was dissolved in water and administered subcutaneously (s.c), as a positive control. Both compounds were administered in a lml/kg volume. Forty eight hours before tests, the animals were primed with 5μg oestradiol benzoate (Sigma Chemical. Co. Ltd., UK) dissolved in com oil and injected subcutaneously. The females were placed with a series of vigorous male rats and subjected to 10 mounts. The lordotic response of the animal was recorded and expressed as a percentage of the mounts (i.e. lordosis quotient, LQ). Treatment induced LQ=0-10% in most of the animals, which were considered non-receptive (NR). Animals showing higher LQ were not included in the study. Each rat was tested prior to administration of the compound and then tested similarly at lh and 90rnin post-injection of the above compound or quinelorane respectively. A single administration of quinelorane (6.25μg/kg) significantly (P<0.01) increased the LQ, 90min after administration, compared to the LQ shown before administration (paired t test). A single oral administration of the above compound dose-dependently (10-lOOmg/kg) increased the LQ lh after admimstration, with a MED of lOOmg/kg (PO.01) compared to the LQ shown before administration (paired t test). The effect of the above compound (lOOmg/kg) was similar to the effect of quinelorane (6.25μg/kg) as is shown in Figure 21. Synthesis Example (compounds of formula (III)) (S)-2-Amino-3-(l JΪ-indol-3-yl)-2-methyl-N-(l-pyridin-2-yI-cyclohexylmethyl)- propionamide (Intermediate HI-7) and (S)-2-Amino-3-(l H r -indoI-3-yl)-2-methyl-N-(l-(5-methoxy-pyridin-2-yI)- cyclohexylmethyl)-propionamide (Intermediate III-6) In reaction scheme 7 below, Intermediates DI-6 and flI-7 are made by (i) protecting the amino group of the starting amino acid a with di-t-butyl carbonate and potassium carbonate in dioxane/water, (ii) forming an amide by reaction of the N- protected amino acid with an amine bl or b_2 in dimethylformamide in the presence of O-benzotriazol-l-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate (HBTU) and NN-diisoproρyl-ethylamine (DIPEA), and (iii) deprotecting the amino group of the product cl or c2 by reaction with trifluoroacetic acid in dichloromethane. cl R = H c2 R = OMe Intermediate 111-7 R = H Intermediate III-6 R = OMe i. BOC 2 O, K 2 CO 3 , dioxane, water ii. HBTU, DIPEA, DMF iii. TFA, CH 2 C1 2 {(S)-2-(l--H-Indol-3-yl)-l-methyl-l-[(l-pyridin-2-yl-cyclohexylmethyl)- carbamoyl]-ethyl}-carbamic acid tert-butyl ester (cl) (1) To a stirred solution of H-(S)-oMeTrp-OH (a) (lOg, 46mmol) and di-t-butyl- dicarbonate (lOg, 46mmol) in dioxane (100ml) was added water (20ml) and potassium carbonate (lOg, 74mmol). After 4 hours the reaction mixture was acidified with 2N hydrochloric acid (150ml) and product extracted with ethyl acetate (2 x 200ml). The combined orgamc phases were dried (MgSO 4 ) and evaporated under reduced pressure. The residue was purified by flash chromatography, eluting with ethyl acetate. Removal of solvent under reduced pressure gave Boc-(S)-oMeTrp-OH as orange oil (14.5g, 99%). (2) To a stiπed solution of Boc-(S)-oMeTrρ-OH (7g, 22mmol) in DMF (100ml) was added HBTU (8.0g, 22mmol), triethylamine (5ml, 35mmol), and [l-(2- pyridyl)cyclohexyl]methylamine (bl, 4.2g, 22mmol, described in WO 98/07718). After 1 hour the reaction mixture was diluted with ethyl acetate (300ml) and washed with 2N hydrochloric acid (2 x 200ml), dried (MgSO 4 ) and evaporated under reduced pressure at 60°C. The residue was purified by flash chromatography. Elution with 5% methanol in dichloromethane and subsequent removal of solvent under reduced pressure gave cl as yellow oil (8.3g, 77%): l-R (fihn): 3339, 2929, 2858, 1704, 1659, 1651, 1589, 1519, 1487, 1366, 1249, 1164, 1070, 908, 737 cm "1 ; NMR (CDC1 3 ): δ = 1.20-1.70 (20H, m), 2.00-2.12 (2H, m), 3.25-3.50 (4H, m), 5.05-5.20 (IH, br.s), 6.92 (IH, d, J=2.0 Hz), 7.02-7.32 (6H, m), 7.51 (IH, d, J=8.0 Hz), 7.59-7.64 (IH, m), 8.03 (IH, s), 8.48 (IH, d, J=4 Hz); MS m/e (AP+): 491 (M 4" + H, 100%), 513 (Iv + Na, 20%). (3) (S)-2-Amino-3-(li3-indol-3-yl)-2-methyl-iV-(l-pyridin-2-yl-cyclohexyl methyl)-propionamide (Intermediate III-7) To a stiπed solution of cl (8.2g, 16.5mmol) in dichloromethane (100ml) was added trifluoroacetic acid (3.0ml, 39mmol). After 18 hours the solvent was removed under reduced pressure at 60°C. The residue was treated cautiously with saturated sodium carbonate solution (200ml) before extracting with ethyl acetate (3 x 200ml). The combined organic phases were dried (MgSO 4 ) and evaporated under reduced pressure at 60°C. The residue was purified by flash chromatography. Elution with 0- 5% methanol in dichloromethane and subsequent removal of solvent under reduced pressure gave Intermediate III-7 as white foam (4.85g, 75%). MPt: 65-68°C; IR (KBr disc): 3367, 2926, 2855, 1648, 1589, 1569, 1522, 1455, 1430, 1366, 1341, 1234, 842, 784, 742 cm "1 ; NMR (CDC1 3 ): δ = 1.20-1.80 (13H, m), 1.98-2.20 (2H, m), 2.83 (IH, d, J=14.2 Hz), 3.33 (IH, d, J=14.2 Hz), 3.38 (2H, d, J=5.6 Hz), 6.98-7.20 (6H, m), 7.50- 7.75 (3H, m), 8.05-8.15 (IH, s), 8.49-8.51 (IH, m); MS m/e (AP+): 391 (Ivf + H, 100%). {(S)-2-(l--H r -Indol-3-yl)-l-methyl-l-[(l-(5-methoxy-pyridin-2-yl)- cyclohexylmethyl)-carbamoyl]-ethyI}-carbamic acid tert-butyl ester (c2) To a stirred solution of Boc-(S)-αMeTrρ-OH (1.44g, 4.5mmol) in DMF (50ml) was added HBTU (1.72g, 4.5mmol), DIPEA (2.38ml, 13.6mmol), and [l-(5- methoxy-2-pyridyl)cyclohexyl]methanamine (lg, 4.5mmol). After over night the reaction mixture was diluted with ethyl acetate (300ml) and water, dried (MgSO 4 ) and evaporated under reduced pressure. The residue was purified by flash chromatography. Elution with ethylacetate/heptane (1:1) and subsequent removal of solvent under reduced pressure gave c2 as an oil (2.207g, 94%). NMR (CDC1 3 ): δ = 1.24-1.60 (8H, m), 1.39 (9H, s), 1.52 (3H, s), 2.00-2.18 (2H, m), 3.20-3.43 (4H, m), 3.82 (3H, s), 6.92 (IH, d, J=2.4 Hz), 7.02-7.20 (6H, m), 7.30 (IH, d, J=6.0 Hz), 7.51 (IH, d, J=8Hz), 8.00 (IH, s), 8.17 (IH, d, J=2.8Hz). MS m/e (ES+): 521.36 (M 4 + H, 100%), 543.25 (M 4 + Na). Intermediate III-6 To a stiπed solution of c2 (2.2g, 4.2mmol) in dichloromethane (10ml) was added trifluoroacetic acid (5ml, excess). After stirring over night the reaction mixture was taken up in IN HCl and extracted with diethylether. Organic phase discarded. The aqueous phase was basified cautiously with saturated sodium carbonate solution before extracting with ethyl acetate (3 x 50ml). The combined organic phases were dried (MgSO ) and evaporated under reduced pressure at 60°C to give Intermediate III-6 as a glass (1.253g, 71%). IR(film): 3272, 2930, 2857, 1651, 1595, 1573, 1520, 1489, 1478, 1455, 1393, 1358, 1291, 1268, 1232, 1181, 1150, 1131, 1030, 1012, 831, 741 cm "1 ; NMR (DMSO): δ = 1.10-1.65 (13H, m), 1.80-1.90 (IH, m), 2.00-2.10 (IH, m), 2.70 (IH, d, J=13.9 Hz), 3.10 (IH, d, J=13.9 Hz), 3.10-3.22 (2H, m), 3.77 (3H,s), 6.93- 7.07 (4H, m), 7.16-7.19 (IH, m), 7.32 (IH, d, J=8.1 Hz), 7.48-7.55 (2H, m), 8.21 (IH, d, J=3.2 Hz), 10.88 (IH, s); MS m/e (ES+): 421.27 (M + H, 100%), 443.26 (M 4 +Na). Examples 32-86 iV-acyl derivatives of Intermediate III-6 and III-7 Scheme 8 describes the synthesis of N-acyl derivatives of Intermediates III-7 and Scheme 8 Intermediate III-7 Examples 32-85 Intermediate 111-6 Example 86 i. HBTU, DIPEA, DMF In scheme 8, Rl represents the rest of the carboxylic acid d molecule. These intermediates d are listed in table 2. N-acyl derivatives of Intermediate III-7 To acid d (0.18 mmol) was added 0.50 M HBTU in DMF (300 μL, 0.15 mmol), 1.0 M diisopropylethylamine in DMF (300 μL, 0.30 mmol) and 0.40 M Intermediate III-7 in DMF (375 μL, 0.15 mmol). The solution was shaken on an orbital shaker at room temperature for 18 h. Water (1.0 mL) was added and the mixture was loaded onto a LC-18 SPE cartridge (0.5 g sorbent) and the cartridge was eluted with water (3 mL), 25% methanol/water (3 mL), 50% methanol/water (4 mL) and methanol (4.5 mL)). The methanol fraction was concentrated and analysed by LCMS. When the purity was <90% the product was further purified by prep. HPLC (column: Phenomenex primesphere 10 μ C18-HC 110A, 100x21.20 mm; mobile phase: methanol / water 10 to 100% gradient). The products were characterised and analysed by LCMS (column: 50x4.6 mm Prodigy ODSID (5μ) column; mobile phase: acetonitrile / water (0.1% formic acid) 5 to 100% gradient over 2 min, held at 100% acetonitrile for 1 min; flow rate 4 mL/min; UN detection at 215 nm; mass spec: 150- 900 Da full scan APCI+ centroid data) The following products were made by the above method, with the starting material listed in Table 2 and gave the test results indicated in Table 3: TABLE 2 TABLE 3 IA: IC50 > 10000 nM N-acyl derivative of Intermediate πi-6 Example 86 lH-Indole-2-carboxylic acid ((S)-2-(lH-indoI-3-yl)-l-{[l-(5-methoxy-pyridin-2- yl)-cyclohexylmethyl]-carbamoyl}-l-methyl-ethyl)-amide To a solution of l-H-Indole-2-carboxylic acid (38 mg, 0.24 mmol), Intermediate III- 6 (100 mg, 0.19 mmol) and diisopropylethylamine (61 mg, 0.47 mmol) in DMF (5 mL) was added ΗBTU (90 mg, 0.24 mmol). The reaction mixture was stiπed at room temperature for 16 h. The reaction mixture was concentrated under reduced pressure and the residue was diluted with ethyl acetate, washed with brine, dried (MgSO 4 ) and concentrated under reduced pressure. The residue was purified by column chromatography (60% ethyl acetate/heptane) to give Example 86 as an amorphous white solid (65 mg, 61%). IR (film): 3285, 2931, 2855, 1651, 1537, 1489, 1456, 1420, 1342, 1310, 1267, 1028, 908, 744 cm "1 ; NMR (CDC1 3 ): δ = 1.10-1.61 (11Η, m), 1.95-2.04 (2Η, m), 3.29-3.52 (4H, m), 3.43 (3H, s), 6.47 (lH,s), 6.86-6.90 (IH, m), 6.98-6.99 (2H, m), 7.09-7.42 (8H, m), 7.52-7.58 (2H, m), 7.73-7.74 (IH, m) 8.05 (IH, s), 9.11 (IH, s); MS m/e (ES+): 564 (M 4 + H, 100%). Binding studies of Example 86 to the bombesin receptors gave the following results (IC 50 ): BBl: 11 nM, BB2: 119 nM. Examples 87-11 N-terminal urethane derivatives of Intermediate III-7 Scheme 9 describes the synthesis of urethane derivatives of Intermediate III-7: - Conversion of alcohol into 4-nitrophenyl carbonates - N-terminal urethane formation Scheme 9 Examples 87-110 i. 4-nitrophenyl chloroformate, pyridine, THF ii. DMAP, DMF In scheme 9, R2 represents the rest of the intermediate e. These intermediates e are listed in table 4. To a stiπed solution of alcohol e (10 mmol) and 4-nitrophenyl chloroformate (2.01 g, 10 mmol) in dichloromethane (50 mL) at 0°C was added dropwise a solution of pyridine (0.81 mL, 10 mmol) in dichloromethane (10 mL). The reaction mixture was allowed to slowly warm to room temperature and was stiπed at room temperature for 16 h. The solvent was removed under reduced pressure and the residue was taken up in ethyl acetate (50 mL) and was washed successively with 10% citric acid (2x30 mL), water (30 mL), sat. NaHCO 3 solution (2x50 mL) and brine (50 mL). The organic phase was dried (MgSO 4 ) and was concentrated under reduced pressure. The crude product was recrystallised from typically ethyl acetate, diethyl ether or heptane to give pure carbonate f . The product was characterised by TR (see Table 4 for carbonate signals). To carbonate f (0.21 mmol) was added DMF (0.4 mL) followed by 0.50 M DMAP in DMF (400 μL, 0.20 mmol) and 0.50 M Intermediate III-7 in DMF (200 μL, 0.10 mmol). The solution was shaken on an orbital shaker at room temperature for 42 h. Water (1.0 mL) was added and the mixture was loaded onto a LC-18 SPE cartridge (0.5 g sorbent) and the cartridge was eluted with 25% methanol/water (3.4 mL) and methanol (4 mL). The methanol fraction was concentrated and purified by prep. HPLC (column: Phenomenex primesphere 10 μ C18-HC 110A, 100x21.20 mm; mobile phase: methanol/water 10 to 100% gradient). The products were characterised and analysed by LCMS (column: 50x4.6 mm Prodigy ODSDI (5μ) column; mobile phase: acetonitrile/water (0.1% formic acid) 5 to 100% gradient over 2 min, held at 100% acetonitrile for 1 min; flow rate 4 mL/min; UN detection at 215 nm; mass spec: 150-900 Da full scan APCI+ centroid data). The following products were made by the above method, with the starting material listed in Table 4 and gave the test results indicated in Table 5: TABLE 4 TABLE 5 Examples 111-168 N-terminal sulfonamide derivatives of Intermediate πi-7 Intermediate III-7 Scheme 10 Examples 111-168 In scheme 10, R3 represents the rest of the intermediate g. These intermediates g are listed in table 6. To sulfonyl chloride g (0.14 mmol) was added 0.143 M Intermediate III-7 in DMF (700 μL, 0.10 mmol) followed by 300 μL of a solution containing a mixture of diisopropylethylamine (0.667 M in DMF, 0.20 mmol) and 4-dimethylaminopyridine (0.033 M in DMF, 0.01 mmol). The reaction mixture was shaken in an orbital shaker at 70°C for 16 h. The crude reaction mixture was loaded onto a 5 g silica cartridge and the cartridge was eluted with ethyl acetate in heptane (30 to 100% gradient). Removal of the solvent under reduced pressure gave the sulfonamides (Examples 111-168). The purity of the sulfonamide was checked by LCMS. Those samples that were less than 95% pure were further purified by prep HPLC (column: YMC-Pack ODS-AM, 5μm, 150x20 mm; mobile phase: acetonitrile / water 40 to 100% gradient). The products were characterised and analysed by LCMS (column: 150x4.6 mm Prodigy ODS3 (3μ) column; mobile phase: acetonitrile (0.085% TFA) / water (0.1% TFA) 20 to 100% gradient over 7 min, held at 100% acetonitrile (0.085% TFA) for 1 min; flow rate 1.5 mL/min; detection: diode array 200-300 nm; mass spec: 150-900 Da full scan APCI+ cenfroid data) (see Table 7). The following examples were made by the above method, with the starting material listed in Table 6 and gave the test results indicated in Table 7: TABLE 6 TABLE 7

Claims: CLAIMS 1. A method of treating sexual dysfunction which comprises administering to a subject suffering therefrom and in need of treatment an effective amount of a bombesin receptor antagonist. 2. The method of claim 1, wherein the dysfunction is associated with hypoactive sexual desfre disorders, sexual arousal disorders, orgasmic disorders or anorgasmy, or sexual pain disorders. 3. The method of claim 1, wherein the dysfunction is associated with generahsed unresponsiveness and ageing-related decline in sexual arousabihty or with drag- induced sexual dysfunction. 4. The method of claim 1 or 2, wherein the subject is a human female. 5. The method of claim 1 or 3, wherein the subject is a human male. 6. The method of any of claims 1-3, wherein the bombesin receptor antagonist has a preferential affinity for the BBi receptor. 7. The method of any preceding claim, wherein there is admiihstered to the subject an effective amount of a non-peptide bombesin receptor antagonist. 8. The method of claim 7, wherein the non-peptide bombesin receptor antagonist is a compound that is absorbable when administered orally. 9. The method of any of claims 1-6, wherein there is administered to the subject an effective amount of a bombesin receptor antagonist which is a peptide. 10. Use of a bombesin receptor antagonist in the manufacture of a medicament for preventing or treating male sexual dysfunction or female sexual dysfunction. 11. The method of any of claims 1 -5, which comprises administering to a subj ect a bombesin receptor antagomst in combination with a vasodilator useful for the freatment of sexual dysfunction. 12. The method of any of claims 1 -5, which comprises administering to a subject • a bombesin receptor antagonist in combination with • a modulator of steroid hormones, a steroid hormone or a hormone product useful for the treatment of sexual dysfunction. 13. The method of any of claims 1-5, which comprises administering to a subject • a bombesin receptor antagonist in combination with • a neurotransmitter agonist or antagonist, a monoamine synthesis modifier, or a monoamine metabolism or uptake modifier useful for the treatment of sexual dysfunction. 14. The method of claim 11 , wherein the vasodilator is a PDE5 inhibitor. 15. The method according to claim 14 wherein the PDE5 inhibitor is sildenafil or a pharmaceutically acceptable salt thereof. 16. The method of claim 11 , wherein the vasodilator is selected from alprostadil or phentolamine. 17. The method of claim 11 , wherein the vasodilator is a ND? enhancer. 18. The method of claim 11 , wherein the vasodilator is a compound that promotes production of NO. 19. The method of claim 12, wherein the steroid hormone is selected from oestrogens or androgens. 20. The method of claim 13, wherein the neurotransmitter agonist or antagonist is selected from quinelorane, ritanserin, para-chlorophenylalanine or imipramine. 21. The method of any of claims 11 -20, wherein • the bombesin receptor antagonist and • the vasodilator, or modulator of steroid hormones, steroid hormone or hormone product, or neurofransmitter agonist or antagomst, monoamine synthesis modifier, or monoamine metabolism or uptake modifier are simultaneously administered to the subject in the form of a composition containing • a unit dose of the bombesin receptor antagonist, • a unit dose of the vasodilator, or modulator of steroid hormones, steroid hormone or hormone product, or neurofransmitter agonist or antagonist, monoamine synthesis modifier, or monoamine metabolism or uptake modifier • and a pharmaceutically acceptable carrier or diluent. 22. The method of claim 21, wherein the composition is in the form of a tablet, capsule, powder, syrup or elixir. 23. The method of any of claims 11-20, wherein • the bombesin receptor antagonist and • the vasodilator, or modulator of steroid hormones, steroid hormone or hormone product, or neurofransmitter agonist or antagonist, monoamine synthesis modifier, or monoamine metabolism or uptake modifier are administered from a kit in which • a unit dose of the bombesin receptor antagonist is provided in association with • a unit dose of the vasodilator, or modulator of steroid hormones, steroid hormone or hormone product, or neurofransmitter agonist or antagonist, monoamine synthesis modifier, or monoamine metabolism or uptake modifier. 24. The method of claim 23, wherein said kit contains a unit dose of the bombesin receptor antagonist for oral administration, and a unit dose of the vasodilator, or the modulator of steroid hormones, steroid hormone or hormone product, or the neurofransmitter agonist or antagonist, monoamine synthesis modifier, or monoamine metabohsm or uptake modifier, in another composition for oral administration, or in a suppository, pessary, cream or transdermal patch.

Inventors: GONZALEZ MARIA ISABEL, HIGGINBOTTOM MICHAEL, PINNOCK ROBERT DENHAM, PRITCHARD MARTYN CLIVE, STOCK HERMAN THIJS, GONZALEZ, MARIA, ISABEL, HIGGINBOTTOM, MICHAEL, PINNOCK, ROBERT, DENHAM, PRITCHARD, MARTYN, CLIVE, STOCK, HERMAN, THIJS
Applicants: GONZALEZ MARIA ISABEL, HIGGINBOTTOM MICHAEL, PINNOCK ROBERT DENHAM, PRITCHARD MARTYN CLIVE, STOCK HERMAN THIJS, WARNER LAMBERT CO, GONZALEZ, MARIA, ISABEL, HIGGINBOTTOM, MICHAEL, PINNOCK, ROBERT, DENHAM, PRITCHARD, MARTYN, CLIVE, STOCK, HERMAN, THIJS, WARNER-LAMBERT COMPANY
Application year: 2000
Main classification: A61K31
IPC codes: A61K31, A61K38, A61K45, A61P15, A61P43, C07D213, C07D401, C07D405, C07D409, C07D413, C07D417