COSMETIC COMPOSITIONS CONTAINING VITAMIN B3

Abstract: Disclosed are cosmetic compositions, including lipsticks, comprising from 0.01 % to about 50 %, by weight, of cylindrical crystalline vitamin B3 particles having a particle size distribution such that at least about 70 % of the crystalline particles have a height to width ratio greater than 1; from about 1 % to about 90 %, by weight, of an emollient component; from about 1 % to about 90 %, by weight, of a solidifying agent; and from about 1 % to about 90 %, on an anhydrous basis, of a color. The compositions provide improved skin feel of crystalline vitamin B3 compounds when applied to skin.

Description: COSMETIC COMPOSITIONS CONTAINING VITAMIN B3 FIELD OF THE INVENTION The present invention relates to topical cosmetic compositions containing cylindrical crystalline vitamin B 3 compounds. BACKGROUND OF THE INVENTION Niacm, also known as vitamm B 3 , is the common name for mcotinic acid. The physiologically active form of niacin is niacinamide, also a member of the vitamm B 3 family of compounds. Niacm and niacinamide (nicotinic acid amide) function in the body as components of two coenzymes: nicotinamide adenine dinucleotide (NAD) and nicotinamide ademne d nucleotide phosphate (NADP) Until recently, these vitamin B 3 compounds were used exclusively to treat macin deficiency and pellegra Today, however, vitamm B 3 compounds have also found use m the area of skm care actives Bπtish Patent 1,370,236 describes compositions for skin lightening containing 0.5% to 10% niacin. Similarly, U.S. Patent 4,096,240 discloses the use of 0 1% to 10% niacinamide for skin lightening. Vitamm B 3 compounds have also been found useful m regulating the texture of human skin. See PCT application WO 97/39733, to Oblong et al However, when applied to the skm in crystallme form (i.e., powder), vitamm B 3 compounds tend to impart a rough feel to the skm In the past, the crystalline vitamm B 3 compounds were solubilized m a polar solvent before application to the skm, destroying the crystallme structure and thereby alleviating the rough feel of the crystals. However, solubilization reduced the efficacy of the vitamm B 3 compound upon contact with the skm. Thus there exists a need for cosmetic compositions compπsmg unsolubilized crystallme vitamm B 3 compound(s) which provide improved consumer perceived skm feel The present inventors have discovered that cosmetic formulations incorporating the crystalline vitamm B 3 compounds of a specific crystallme structure and an emollient improve the consumer perceived feel of the vitamin B 3 compound on the skm The present inventors have further discovered that these compositions are especially useful to impart vitamm B 3 benefits to the lips with improved skm feel when used m lipstick compositions mcludmg a solidifying agent It is, therefore, an aspect of the present invention to provide cosmetic compositions, preferably anhydrous cosmetic compositions, compπsmg select crystalline structured vitamm B 3 compounds which improve the appearance and feel of the skm while alleviatmg the rough feel of the crystallme vitamm B3 compound. Another aspect of the present invention is to provide anhydrous cosmetic compositions compnsmg selected crystallme structure vitamm B 3 compounds which improve the feel of the vitamin B 3 compound on the skm. These and other aspects will become readily apparent from the detailed descπption which follows SUMMARY OF THE INVENTION The present invention relates to cosmetic compositions providing improved skin feel, which contain from about 0.01% to about 50%, by weight, of cylindrical crystalline vitamin B 3 compound particles having a particle size distribution such that at least about 70% of the crystalline particles have a height to width ratio greater than 1 ; from about 1% to about 90%, by weight, of an emollient; from about 1% to about 90%, by weight, of a solidifying agent; and from about 1% to about 90%, on an anhydrous basis, of a color. Preferably the compositions are anhydrous. The compositions of the present invention are useful for improving consumer perceived skin feel of cylindrical crystalline vitamin B3 compounds when applied to the skin. All percentages, parts and ratios are based upon the total weight of the cosmetic compositions of the present invention, unless otherwise specified. All such weights as they pertain to listed ingredients are based on the active level and, therefore, do not include carriers or by-products that may be included in commercially available materials, unless otherwise specified. DETAILED DESCRIPTION OF THE INVENTION As used herein, the term "cosmetics" includes make-up, foundation, and skin care products. The term "make-up" refers to products that leave color on the face, including foundation, blacks and browns, i.e., mascara, eye liners, brow colors, eye shadows, blushers, lip colors, and so forth. Skin care products are those used to treat or care for, or somehow moisturize, improve, or clean the skin. Products contemplated by the phrase "skin care products" include, but are not limited to, adhesives, bandages, toothpaste, anhydrous occlusive moisturizers, powder laundry detergent, fabric softener towels, occlusive drug delivery patches, antiperspirants, deodorants, nail polish, powders, tissues, wipes, solid emulsion compact, hair conditioners-anhydrous and the like. The term "foundation" refers to liquid, creme, mousse, pancake, concealer or like product created or reintroduced by cosmetic companies to even out the overall coloring of the skin. Foundation is manufactured to work better over moisturized and/or oiled skin. As used herein the term "comprising" means that the composition can contain other ingredients which are compatible with the composition and which preferably do not substantially disrupt the compositions of the present invention. The term encompasses the terms "consisting of and "consisting essentially of. ESSENTIAL COMPONENTS Vitamin B Compound The compositions of the present invention comprise a safe and effective amount of a natural or synthetic cylindrical crystalline vitamin B3 compound. The compositions of the present invention preferably comprise from above 0.01% to about 50%, more preferably from about 0.1% to about 30%, even more preferably 0.5% to about 20%, most preferably from about 1% to about 10% of the vitamin B3 compound. As used herein, "vitamin B3 compound" means a compound having the formula: wherem R is - CONH2 (ι e., niacinamide), - COOH (i.e., nicotinic acid) or - CH2OH (1 e , nicotinyl alcohol), denvatives thereof; and salts of any of the foregomg Exemplary denvatives of these vitamm B3 compounds as used herem mclude vitamm B 3 derivatives known m the art such as nicotinic acid esters, mcludmg non-vasodilatmg esters of nicotinic acid, mcotmyl ammo acids, and mcotmyl alcohol esters of carboxyhc acids, and also mclude nicotinic acid N-oxide and niacinamide N-oxide Suitable esters of nicotinic acid include nicotinic acid esters of C1 -C22. preferably more preferably Ci -Cg alcohols The alcohols are suitably straight-chain or branched cham, cyclic or acyclic, saturated or unsaturated (mcludmg aromatic), and substimted or unsubstituted. The esters are preferably non-rubifacient. As used herem, "non-rubifacient" means that the ester does not commonly yield a visible flushing response after application to the skm m the subject compositions (the majority of the general population would not expeπence a visible flushing response, although such compounds may cause vasodilation not visible to the naked eye). Alternatively, a nicotinic acid material which is mbifacient at higher doses could be used at a lower dose to reduce the mbifacient effect. Non-rubifacient esters of nicotinic acid include tocopherol mcotinate and mositol hexamcotmate. Other denvatives of the vitamm B3 compound are denvatives of niacinamide resultmg from substitution of one or more of the amide group hydrogens. Nonlimiting examples of denvatives of niacinamide useful herein include mcotmyl ammo acids, denved, for example, from the reaction of an activated nicotinic acid compound (e.g , nicotinic acid azide or mcotmyl chloπde) with an ammo acid, and mcotmyl alcohol esters of organic carboxyhc acids (e.g., Cl - C18) Specific examples of such denvatives mclude nicotinuπc acid, which has the following chemical structure- mcotmuπc acid: Exemplary mcotmyl alcohol esters mclude mcotmyl alcohol esters of the carboxyhc acids salicylic acid, acetic acid, glyco c acid, palmitic acid and the like. Other non-limiting examples of vitamm B3 compounds useful herem are 2-chloronιcotιnamιde, 6-amιnonιcotιnamιde, 6-methylnicotinamide, n-methyl- nicotinamide, n,n-dιethylnιcotιnamιde, n-(hydroxymethyl)-mcotmamide, quinolinic acid amide, nicotinanihde, n-benzylnicotinamide, n-ethylnicotinamide, mfenazone, nicotinaldehyde, lsonicotinic acid, methyl lsonicotinic acid, thionicotinamide, malamide, l-(3-pyndyhnethyl) urea, 2-mercaptonιcotιnιc acid, mcomol, and maprazme Examples of the above vitamm B3 compounds are well known in the art and are commercially available from a number of sources, e g , the Sigma Chemical Company (St Louis, MO), ICN Biomedicals, Inc (Irvin, CA) and Aldnch Chemical Company (Milwaukee, WI) One or more vitamm B3 compounds may be used herem Preferred vitamm B3 compounds are mcotimc acid, niacinamide, tocopherol nicotinate, nicotinic acid Ν-oxide and niacinamide Ν-oxide Niacinamide is more preferred Salts of the vitamm B3 compound are also useful herein Nonlimitmg examples of salts of the vitamm B3 compound useful herem include organic or inorganic salts, such as inorganic salts with anionic inorganic species (e g , chlonde, bromide, iodide, carbonate, preferably chloride), and orgamc carboxyhc acid salts (mcludmg mono-, di- and tπ- Cl - C18 carboxyhc acid salts, e g , acetate, sahcylate, glycolate, lactate, malate, citrate, preferably monocarboxy c acid salts such as acetate) These and other salts of the vitamm B3 compound can be readily prepared by the skilled artisan, for example, as descnbed by W Wenner, "The Reaction of L-Ascorbic and D-Isoascorbic Acid with Nicotinic Acid and Its Amide", J Orgamc Chemistry, VOL 14, 22-26 (1949), which is incorporated herein by reference Wenner descnbes the synthesis of the ascorbic acid salt of niacinamide When used, salts, denvatives, and salt denvatives of niacinamide are preferably those havmg substantially the same efficacy as niacinamide m the methods of regulatmg skm condition descnbed herem In a prefened embodiment, the ring nitrogen of the vitamm B3 compound is substantially chemically free (e g , unbound and/or unhindered), or after delivery to the skm becomes substantially chemically free ("chemically free" is hereinafter alternatively refeπed to as "uncomplexed") More preferably, the vitamm B3 compound is essentially uncomplexed Therefore, if the composition contains the vitamm B3 compound m a salt or otherwise complexed form, such complex is preferably substantially reversible, more preferably essentially reversible, upon delivery of the composition to the skm For example, such complex should be substantially reversible at a pH of from about 5 0 to about 6 0 Such reversibility can be readily determined by one havmg ordinary skill in the art More preferably the vitamm B3 compound is substantially uncomplexed m the composition pnor to delivery to the skm Exemplary approaches to minimizing or preventmg the formation of undesirable complexes mclude omission of materials which form substantially meversible or other complexes with the vitamm B3 compound, pH adjustment, lomc strength adjustment, the use of surfactants, and formulating wherem the vitamm B3 compound and materials which complex therewith are m different phases Such approaches are well within the level of ordinary skill m the art Thus, m a preferred embodiment, the vitamm B3 compound contains a limited amount of the salt form and is more preferably substantially free of salts of a vitamm B3 compound Preferably the vitamm B3 compound contains less than about 50% of such salt, and is more preferably essentially free of the salt form The vitamm B3 compound in the compositions hereof havmg a pH of from about 4 to about 7 typically contam less than about 50% of the salt form. The vitamm B3 compound may be mcluded as the substantially pure mateπal, or as an extract obtained by suitable physical and/or chemical isolation from natural (e g., plant) sources. The vitamin B3 compound is preferably substantially pure, more preferably essentially pure. The vitamm B 3 compounds of the present invention compnse cylmdncal crystallme particles havmg a particle size distribution such that at least about 70% of the crystallme particles have a height to width ratio greater than 1 or about 1, preferably, at least about 70% of the crystallme particles have a height to width ratio greater than 1 5 or about 1.5, more preferably at least about 50% of the crystallme particles have a height to width ratio greater than 2 or about 2 Preferably, the vitamm B 3 crystals particles havmg an average primary particle size length of from about 0.01 μm (microns) to about 200μm, preferably from about 0.0 lμm to about lOOμm, more preferably from about 0.0 lμm to about 50μm, most preferably from about 0 Olμm to about 20μm. Preferably, the vitamm B 3 compounds have a particle size distribution such that at least about 60% of the vitamm B 3 particles are less than about 30μm, more preferably at least about 75% of the vitamm B 3 particles are less than about 30μm, most preferably at least about 85% of the vitamm B 3 particles are less than about 30μm, still more preferably at least about 90% of the vitamm B 3 particles are less than about 30μm m length. The unproved vitamm B 3 compound crystals can be prepared by dissolving the raw or neat vitamm B 3 compound m a suitable solvent and recrystallizmg the compound using any of a vanety of conventional crystallization techniques, but preparation is not limited to this method Such crystallization techniques mclude, but are not limited to, evaporation from a smgle solvent, evaporation from a binary mixture of solvents (volatile solvent and non-volatile solvent), batch crystallization, liquid-liquid diffusion, sitting-drop vapor-phase diffusion, hanging-drop vapor-phase diffusion, temperature change, gel crystallization sublimation and solidification These crystallization techniques are m greater descnbed m Van der Sims, P , Hezemans, A.M.F., and Kroon, J, Crystallization of Low-Molecular-Weight Orgamc Compounds for X-ray Crystallization, J Appl. Cryst (1989).22, 340-344 and Alexander McPherson, Preparation and Analysis of Protem Crystals, Robert E. Krieger Publishing Co. (1989), both of which are herem incorporated by reference in their entirety Emollient Component The compositions of the present mvention further comprise an emollient suitable for suspendmg or otherwise dispersmg the crystallme vitamm B3 compound therein. Any emollient that is known or otherwise suitable for use m cosmetic applications, and which is also compatible with the cylmdncal crystalline vitamm B3 compound m the composition, may be used in the composition of the present mvention Preferred emollients for use m the composition of the present invention are those matenals referred to in the personal care arts as fats, oils, fatty alcohols, fatty acids, esters of fatty acids, and combmations thereof, and which aid application and adhesion, yield gloss and/or provide occlusive moistunzation. The emollient component compπses from about 1% to about 90%, preferably from about 10% to about 80%), more preferably from about 20% to about 70%, and most preferably from about 40% to about 60%, of the cosmetic composition. Suitable emollients for use m the present mvention mclude isosteanc acid denvatives, isopropyl palmitate, lanolin oil, dusopropyl dimerate, maleated soybean oil, octyl palmitate, isopropyl isostearate, cetyl lactate, cetyl πcinoleate, tocopheryl acetate, acetylated lanolm alcohol, cetyl acetate, phenyl tnmethicone, glyceryl oleate, tocopheryl hnoleate, wheat germ glycendes, arachidyl propionate, mynstyl lactate, decyl oleate, propylene glycol πcinoleate, isopropyl lanolate, pentaerythπtyl tetrastearate, neopenrylglycol dicaprylate/dicaprate, hydrogenated coco-glycendes, isononyl isononanoate, isotπdecyl isononanoate, myπstal myπstate, tπisocetyl citrate, cetyl alcohol, octyl dodecanol, oleyl alcohol, panthenol, lanolm alcohol, Imoleic acid, Imolenic acid, sucrose esters of fatty acids, octyl hydroxystearate and mixtures thereof. Examples of other suitable emollients are described m the Cosmetic Bench Reference, pp. 1.19-1.22 (1996), which descπptions are incorporated herem by reference. Particularly prefeπed for use herem are non-polar emollients. By "non-polar emollient," as used herem, means any emollient emulsifier possessmg no permanent electπc moments and wherem the solubility (at 30°C) of the vitamm B 3 compound is m the polar emollient is less than about 1.5% preferably less than about 1.0%, more preferably less than about 0.5%. Suitable non-polar emollients mclude, but are not limited to, esters and lmear or branched chamed hydrocarbons Nonlimit g examples of such emollients isononyl isononanoate, isopropyl isostearate, octyl hydroxystearate, dusopropyl dimerate, lanolm oil, octyl palmitate, isopropyl palmitate, panffins, isoparπfins, acetylated lanolm, sucrose fatty acid esters, isopropyl mynstate, isopropyl stearate, mineral oil, sihcone oils, dimefhicone, allantoin, isohexadecane, isododecane, petrolatum, and mixtures thereof. As used herem, the solubility of the vitamm B3 compound m non-polar emollients is determined as by the methodology descnbed hereinafter. Suitable oil emollients for use m the compositions of the present invention mclude esters, tnglycendes, hydrocarbons and sihcones. These can be a smgle matenal or a mixture of one or more matenals. They will normally comprise from 1% to about 100%, preferably from about 5% to about 90%, and most preferably from about 70% to about 90% of the emollient component Oils act as emollients and can also impart viscosity, tackiness, and drag properties to cosmetic compositions such as lipsticks. Examples of suitable oils mclude capryhc tnglycendes; capnc tnglycende; isosteanc tnglycende; adipic tnglycende; propylene glycol mynstyl acetate, lanolm; lanolm oil; polybutene; isopropyl palmitate, isopropyl myπstate; isopropyl isostearate; diethyl sebacate; dusopropyl adipate; tocopheryl acetate, tocopheryl hnoleate; hexadecyl stearate; ethyl lactate; cetyl oleate; cetyl ncmoleate; oleyl alcohol; hexadecyl alcohol; octyl hydroxystearate; octyl dodecanol; wheat germ oil; hydrogenated vegetable oils, castor oil; petrolatum; modified lanolins; branched-cham hydrocarbons; alcohols and esters; corn oil; cottonseed oil; olive oil; palm kernel oil; rapeseed oil; safflower oil; jojoba oil; evening primrose oil; avocado oil mineral oil, sheabutter, octylpalmitate, maleated soybean oil, glycerol trioctanoate, dusopropyl dimerate, and volatile and non-volatile silicone oils including phenyl trimethicone. The preferred oils for use herein are acerylglycerides, octanoates, and decanoates of alcohols and polyalcohols, such as those of glycol and glycerol, the ricinoleates of alcohols and polyalcohols such as cetyl ricinoleate, PG-3 diisostearate, polyglycerol ethers, polyglycerol esters, caprylic triglycerides, capric triglycerides, isostearic triglyceride, adipic triglyceride, phenyl trimethicone, lanolin oil, polybutene, isopropyl palmitate, isopropyl isostearate, cetyl ricinoleate, octyl dodecanol, oleyl alcohol, hydrogenated vegetable oils, castor oil, modified lanolins, octyl palmitate, lanolin oil, maleated soybean oil, cetyl ricinoleate, glyceryl trioctanoate, dusopropyl dimerate, synthetic lanolin derivatives and branched chain alcohols, sucrose esters of fatty acids, octyl hydroxystearate and mixtures thereof. Preferably, the oils used are selected such that the majority (at least about 75%, preferably at least about 80% and most preferably at least about 99%) of the types of oils used have solubility parameters which do not differ by more than from about 1 to about 0.1, preferably from about 0.8 to about 0.1. Optional Components Solidifying Agent The cosmetic compositions of the present invention may further comprise a solidifying agent to solidify or trap any liquid base materials in the cosmetic composition. As used herein, the term "solidify" refers to the physical and/or chemical alteration of the liquid base material so as to form a solid or semi- solid at ambient conditions, i.e., to form a final composition which has a stable physical structure and is deposited on the skin during normal use conditions. As is appreciated by those skilled in the art, the selection of the particular solidifying agent for use in the cosmetic compositions will depend upon the particular type of composition desired, i.e., gel or wax-based, the desired rheology, the liquid base material used and the other materials to be used in the composition. The solidifying agent is preferably present at a concentration of from about 1% to about 90%, more preferably from about 1 to about 50%, even more preferably from about 5% to about 40%, most preferably from about 3% to about 20%. The wax cosmetic stick embodiments of this invention preferably contain from about 5% to about 50%> (by weight) of a waxy solidifying agent. The term "waxy solidifying agent," as used herein, refers to a solidifying material having wax-like characteristics. Such waxy materials may also serve as emollients. Among the waxy materials useful herein are the high melting point waxes, i.e., having a melting point of from about 65°C to about 125°C, such as beeswax, spermaceti, camauba, baysberry, candelilla, montan, ozokerite, ceresin, paraffin, synthetic waxes such as Fisher-Tropsch waxes, microcrystalline wax, and mixtures thereof. Ceresin, ozokerite, white beeswax, synthetic waxes, and mixtures thereof, are among the preferred high-melting point waxes useful herein. Compositions containing waxes among those useful herein are disclosed in U.S. Patent 4,049,792, Elsnau, issued Sept. 20, 1977, herein incorporated by reference in its entirety). Low melting waxes, having a melting point of from about 37°C to about 75°C, are preferred for use in the wax stick embodiments of this invention. Wax stick embodiments of this invention, which contain volatile silicone oils as a liquid base mateπal, preferably contain from about 10% to about 35%, more preferably from about 10% to about 20% (by weight), of a low-melting wax Such matenals mclude fatty acids, fatty alcohols, fatty acid esters and fatty acids amides, havmg fatty chains of from about 8 to about 30 carbon atoms, and mixtures thereof Prefeπed wax-like matenals mclude cetyl alcohol, palmitic acid, stearyl alcohol, behenamide, sucrose esters of tallow fatty acids, mono and di-fatty acid esters of polyethylene glycol, and mixtures thereof Stearyl alcohol, cetyl alcohol, and mixtures thereof, are particularly preferred Fatty acids, fatty alcohols, and other wax-like matenals useful m this mvention are also disclosed in the following references, all of which are incorporated by reference herem U S Patent 4,151,272, Geary, et al , issued Apr 24, 1979, U S Patent 4,229,432, Gena, issued Oct 21, 1980, and U S Patent 4,280,994, Turney, issued July 28, 1981, "The Chemistry and Technology of Waxes", A H Warth, 2nd Edition, reprinted m 1960, Reinhold Publishing Corporation, pp 391-393 and 421, "The Petroleum Chemicals Industry", R F Goldstein and A L Waddeam, 3rd Edition (1967), E & F N Span Ltd , pp 33-40, "The Chemistry and Manufacture of Cosmencs", M G DeNavarre, 2nd edition ( 1970), Van Nostrand & Company, pp 354-376, and m "Encylopedia of Chemical Technology , Vol 24, Kirk- Othmer, 3rd Edition (1979) pp 466-481 Preferred wax-like matenals useful as sohdifymg agents m the present wax sticks are descnbed in U S Patent 4,126,679, Davy, et al , issued Nov 21, 1978, herem incorporated by reference in its entirety Preferred mixtures of wax-like matenals compnse fatty alcohols contauung carbon chams of from about 14 to about 18 carbon atoms, and alcohols havmg cham lengths of 20 carbons or longer, wherem the final mixture contains from about 1% to about 3% (by weight) of the longer-chain fatty alcohols Compositions contauung these fatty alcohol mixtures are descnbed m European Patent Specification No 117,070, May, published Aug 29, 1984 (incorporated by reference herem) Also useful herein are biopolymers such as those descnbed m European Application No 522624, to Dunphy et al , herem incorporated by reference in its entirety The gel stick embodiments of this invention preferably contain from about 3% to about 30%, preferably from about 3% to about 10% (by weight), of a sohdifymg agent The particular amount of sohdifymg agent to be used will depend upon the particular solidifying agent and the liquid base mateπal used, and the desired physical charactenstics of the gel stick Sohdifymg agents useful m the gel stick embodiments of this mvention are, in general, surface-active compounds which form networks immobilizing or sohdifymg the liquid base matenals mto a gel Such sohdifymg agents mclude soaps, such as the sodium and potassium salts of higher fatty acids, I e , acids havmg from 12 to 22 carbon atoms, amides of higher fatty acids, higher fatty acid amides of alkylolamines, dibenzaldehyde-monosorbitol acetals, alkali metal and alkaline earth metal salts of the acetates, propionates and lactates, waxes, such as candelilla and camauba waxes, and mixtures thereof Among those sohdifymg agents preferred for use in the gel stick embodiments of this mvention are sodium stearate, sodium palmitate, aluminum stearate, aluminum magnesium hydroxy stearate, and mixtures thereof Gel stick compositions contauung sohdifymg agents among those useful herem are descnbed in the following patent documents, all incorporated herem by reference m their entirety: U.S. Patent 2,900,306, Slater, issued Aug. 18, 1959; U.S. Patent 3,255,082, Barton, issued June 7, 1966; U.S. Patent 4,137,306, Rubmo, et al., issued Jan. 30, 1979, U.S. Patent 4,154,816, Roehl, et al., issued May 15, 1979, U S. Patent 4,226,889, Yuhas, issued Oct. 7, 1980, U S Patent 4,346,079, Roehl, issued Aug. 24, 1982, U.S. Patent 4,383,988, Teng, et al., issued May 17, 1983; European Patent Specification No 107,330, Luebbe, et al , published May 2, 1984, and U.S. patent application Ser. No 630,790, DiPietro, filed July 13, 1984 Preferred sohdifymg agents useful m the gel stick embodiments of the present mvention are descnbed m European Patent Specification No. 24,365 Sampson, et al., published Mar. 4, 1981, incorporated herem by reference in its entirety Also useful herem as solidifying agents are conventional thickening agents. Examples of suitable thickeners mclude, but are not limited to, naturally-occurring polymeπc matenals such as, locust bean gum, sodium algmate, sodium casemate, egg albumin, gelatm agar, caπageenin gum sodium algmate, xanthan gum, qumce seed extract, tragacanth gum, starch, chemically modified starches and the like, semi-synthetic polymeπc materials such as cellulose ethers (e g. hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxy propylmethyl cellulose), polyvinylpyrrohdone, polyvinylalcohol, guar gum, hydroxypropyl guar gum, soluble starch, catiomc celluloses, catiomc guars and the like and synthetic polymeric matenals such as carboxyvinyl polymers, polyvinylpyrrohdone, polyvinyl alcohol polyacryhc acid polymers, polymethacrylic acid polymers, polyvinyl acetate polymers, polyvinyl chlonde polymers, polyvmyhdene chlonde polymers and the like. Inorgamc thickeners may also be used such as alummium silicates, such as, for example, bentomtes, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate. Naturally occurring polymers or biopolymers and their use are further descnbed m European Application No 522624, to Dunphy et al Additional examples of naturally occurring polymers or biopolymers can be found m the Cosmetic Bench Reference, pp 1.40-1.42, herem incorporated by reference Also useful herem are hydrophihc gelling agents such as the acrylic acid/ethyl acrylate copolymers and the carboxyvinyl polymers sold by the B F Goodπch Company under the trademark of Carbopol Registered TM resins These resms consist essentially of a colloidally water-soluble polyalkenyl polyether crosslinked polymer of acrylic acid crosslinked with from 0.75% to 2 00% of a crosslinking agent such as polyallyl sucrose or polyallyl pentaerythntol Examples mclude Carbopol 934, Carbopol 940, Carbopol 950, Carbopol 980, Carbopol 951 and Carbopol 981. Carbopol 934 is a water-soluble polymer of acrylic acid crosslinked with about 1% of a polyallyl ether of sucrose havmg an average of about 5 8 allyl groups for each sucrose molecule. Also suitable for use herem are carbomers sold under the Trade Name "Carbopol Ultrez 10, Carbopol ETD2020, Carbopol 1382, Carbopol 1342 and Pemulen TR-1 (CTFA Designation: Acrylates/ 10-30 Alkyl Acrylate Crosspolymer) Combmabon of the above polymers are also useful herem. Other gelling agents suitable for use herem mclude oleogels such as tnhydroxysteann. Hydrophobically modified celluloses are also suitable for use herem. These celluloses are descnbed in detail m U S. Patents 4,228,277 and 5,104,646, both of which are herem incorporated by reference m then entirety Additional examples of suitable gelling agents or gellants can be found m the Cosmetic Bench Reference, p 1 27, herem incorporated by reference Without bemg limited by theory, the sohdifymg agent m combination with the emollient is believed to act as an occlusive on the skm by formmg continuous or discontinuous bi-layer or multi-layer films on the skm The term "occlusive," as used herein, means a preventmg or obstructing something, m this case, preventmg the removal of moisture (via evaporation) and the vitamm B 3 compound (via film bmdmg) from the surface of the skm Color Certain embodiments of the present invention, preferably lipsticks or hp pamts, may further compπse from about 1% to about 90%, preferably from about 1% to about 35%, more preferably from about 1% to about 20% and most preferably from about 5% to about 15%, of color, on an anhydrous pigment weight basis These are usually aluminum, baπum or calcium salts or lakes Preferably, dyes are present at from about 0 1% to about 4% and pearls from 0% to about 20% Pigments are typically dispersed m emollients for the good dispersion of the pigments when incorporated mto the hp compositions, thus providing an even distnbution of color Colors/pigments suitable for use herem are all inorganic and orgamc colors/pigments suitable for use m lipstick compositions Lakes are either a pigment that is extended or reduced with a solid diluent or an orgamc pigment that is prepared by the precipitation of a water-soluble dye on an adsorptive surface, which usually is aluminum hydrate There is uncertainty m some instances as to whether the soluble dye precipitates on the surface of the aluminum hydrate to yield a dyed morgamc pigment or whether it merely precipitates m the presence of the substrate A lake also forms from precipitation of an insoluble salt from an acid or basic dye Calcium and banum lakes can also be used herein Lakes suitable for use m the present mvention mclude Red 3 Aluminum Lake, Red 21 Aluminum Lake, Red 27 Aluminum Lake, Red 28 Alummum Lake, Red 33 Aluminum Lake, Yellow 5 Aluminum Lake, Yellow 6 Alummum Lake, Yellow 10 Alummum Lake, Orange 5 Alummum Lake and Blue 1 Alummum Lake, Red 6 Baπum Lake, Red 7 Calcium Lake Other colors and pigments can also be mcluded in the lipsticks, such as dyes and pearls, titanium dioxides, Red 6, Red 21, Brown, Russet and Sienna dyes, chalk, talc, iron oxides and titanated micas Dispersants may also be used in conjunction with the colors and pigments of the present mvention Examples of suitable dispersants mclude, but are not limited to, those descnbed m U S Patent 5,688,493, herem incorporated by reference m its entirety Dermatologicallv Acceptable Anhydrous Carrier The composition of the present invention may further compnse a dermatologically acceptable anhydrous vehicle or earner, m addition to the emollient component descnbed herem below Such a earner should be compatible with the skm, the nails, the mucous membranes, tissues and the hair and mcludes any conventionally used cosmetic or dermatological earner which meets these requirements Such a earner should also be compatible with the crystallme vitamm B 3 compound, that is the earner should not interact with or substantially dissolve the crystallme vitamm B 3 compound. The crystalline vitamm B3 compound is preferably dispersed in the emollient component of the composition. The emollient can be part of the earner system. Suitable earners other than the emollients descnbed herem before mclude, but are not limited to, ointment, lipsticks, foundations, mascaras, powders, suspensions, creams, lotions, gels, foams, mousses and the like. These earners facilitate topical application and, m some cases, provide additional therapeutic effects, e.g., by moisturizing the affected skm areas. Dermatologically acceptable anhydrous earners can be readily selected by one of ordinary skill in the art Preferably, the earner is substantially anhydrous In this context "substantially anhydrous" means that the earner provides the composition with less than 20%), preferably less than 5%, more preferably less than 1%, most preferably 0% of free or unbound water by weight of the composition Substantially Free of Polar Solvents The present mvention is, preferably, substantially free of polar solvents In general, "polar solvents" refers to those solvents that contam hydroxyl and/or carbonyl groups and also have high dielectnc constants and strong polarity In general, the phrase "substantially free" means the level of such polar solvents or polar solvent mixtures is preferably less than about 0.5%, more preferably 0 1% and is most preferably 0% Without bemg limited by theory, such polar solvents tend to dissolve or otherwise mteract with the crystalline structure of the vitamm B 3 compounds Examples of such polar solvents mclude, but are not limited to, water; alcohols, such as ethanol, propyl alcohol, isopropyl alcohol, hexanol, and benzyl alcohol, polyols, such as propylene glycol, polypropylene glycol, butylene glycol, hexyleneglycol, maltitol, sorbitol, and glyceπne; panthenol dissolved in glycenne; flavor oils, and mixtures thereof. Other Additives Other optional ingredients which can be present m the cosmetic compositions of the present mvention mclude flavor oils, fat soluble vitamins such as vitamm A and E, esters of vitamm A (e.g., acetate, propionate, or palmitate) and of vitamm E (e.g., acetate or sorbate), sunscreens such as octyl methoxycmnamate, butyl methoxydibenzoyhnethane, titamum dioxide and z c oxide, germicides such as tnclosan, anti-inflammatory agents such as hydrocortisone, lipid matenals such as ceramides and hposomes and other skm care actives The cosmetic compositions can compnse ingredients conventionally employed m cosmetic compositions such as mascara, foundation or hpcare products. This mcludes skm care active ingredients such as pharmaceutically active ingredients Skm care actives ingredients m both water soluble and water insoluble forms can be added to the cosmetic compositions of the present mvention. These mclude, but are not limited to vitamm C and its denvatives (e.g., ascorbyl palmitate, ascorbyl phosphate and its salts such as magnesium or sodium), vitamm D, panthenol, reπnoic acid, zmc oxide, beta-glycyerhetic acid, chamomile oil; g nko biloba extract; pyroglutamic acid, salts or esters; sodium hyaluronate, 2-hydroxyoctanoιc acid; sulfur; salicylic acid, carboxymethyl cysteine, and mixtures thereof These additives, both fat soluble and water soluble, will normally be present m amounts of less than about 10% by weight, and generally m the range of about 0 01% to about 5%>, preferably from about 0 01% to about 3%, most preferably from about 0 1% to about 1%, by weight Orgamc bmders such as steaπc acid, paraffin, butyl acetate, copolymer of ethylene and vmyl acetate, methacryhc acid butyl ester, dibutyl phthalate, polyester and mixmres thereof can also be used in the present mvention Flavor oils such as peppermint oil, orange oil, citrus oil, wmtergreen oil can be used along with an alcohol or glycerine Flavor oils are usually mixed m a solvent such as ethanol to dilute the flavor The flavor oils useful herem can be denved from natural sources or be synthetically prepared Generally flavor oils are mixtures of ketones, alcohols, fatty acids, esters and terpenes The term "flavor oil" is generally recognized m the art to be a liquid which is denved from botanical sources, 1 e leaves, bark, or skm of fruits or vegetables, and which are usually insoluble m water The level of flavor oil used can range from 0%> to about 5%, preferable from about 0 01% to about 1% Additional moisturizers may also be mcluded into the present compositions Prefeπed moisturizers mclude pyrrohdone carboxyhc acid, sodium lactate or lactic acid, urea, guanidine, glyceπc acid and its salts (e g , calcium salt), petrolatum, collagen, α-hydroxy propylglyceryl ether, α-hydroxy acids (e g , efhylglycohc acid, leucic acid, mandehc acid, glycohc acid), glucosamines, and elastin fibers, D- panthenol, allantom and hyaluromc acid and chondroitin sulfate Examples of suitable moisturizers can be found m Cosmetic Bench Reference, p 1 30-1 32 (1996), herem incorporated by reference Surfactants can also be added to the compositions of the present invention Suitable surfactants are those capable of formmg association structures m contact with a polar solvent Examples of such surfactants can be found in U S Patent 5,843,407 to El-Nokaly, herein incorporated by reference When used, the surfactants are preferably present at a concentration of from about 0 1% to about 30%, more preferably 1% to about 15%, most preferably from about 1% to about 5% by weight of the composition Also useful herem are emulsifiers commonly known as couplmg agents when used, the overall concentration of the emulsifier can be from 0% to about 20% of the formulation, preferably from 0% to about 15%), more preferably from about 0 1%> to about 15% and most preferably from about 1%> to about 10%) Examples of suitable emulsifiers can be found in U S Patent 5,085,856 to Dunphy et al , Japanese Patent Publication Sho 61-83110, European Patent Application EP 522624 to Dunphy et al , U S patent 5,688,831 to El-Nokaly et al Examples of other suitable emulsifiers can be found in Cosmetic Bench Reference, pp 1 22, 1 24-1 26 (1996), all of which are herem incorporated by reference m their entirety Mixtures of the above surfactants and emulsifiers can also be used A prefened optional component is ethyl cellulose (Ethocel) Ethyl cellulose generally is preferred for use at levels of about 5% and more preferably 1% Another prefeπed optional component is silica Silica is generally prefeπed for use at levels of from about 1%> and about 5%> Hypoallergenic compositions can be made from the liquid crystal, wax, oil and colors herem These compositions should not contain fragrances, flavor oils, lanolm, sunscreens, particularly PABA, or other sensitizers or potential sensitrzers and irntants The compositions of the present invention can also be made mto long lastmg or non-transferable cosmetic compositions Detailed discussions of such lipsticks are found in Japanese Patent Publication Hei No 6-199630 and European Patent Application 748622, both of which are herein incorporated by reference in their entirety Additional optional materials that can be incorporated in the compositions of the present mvention can be found m PCT application WO 97/39733, to Oblong et al METHODS OF USE The cosmetic compositions of the present mvention are ideally suited for use m treating the skm and lips, especially m the form of a lipstick or lip balm for applying to the lips a permanent or semipermanent color, ideally with a gloss or luster ftαish The cosmetic compositions can also be used m treating the skm and/or lips with a skm care agent for protection against exposure to adverse weather, mcludmg the wind and the ram, dry and/or hot environments, environmental pollutants (e g , ozone, smoke, and the like), or exposure to excessive doses of sunlight The compositions are also useful m providmg sun protection, moistunzmg and or conditionmg for the hair and skm, improved skm feel, regulatmg skm texture, reducmg fine lmes and wrinkles, reducmg oily shine on hair or skm, skm lightening and reducmg skm or han odor The cosmetic compositions can, accordmgly, be applied to the skm and/or lips m the traditional manner using a convement holder or applicator to provide a decorative and/or protective film thereto Methods of Determining Solubility of Vitamin B 3 Compounds in Emollients The solubility of the vitamm B 3 compound m the vanous non-polar emollients of the present invention can be determined as follows I Preparation of Samples for Analysis 1 ) the emollient is placed m pre-weighted vial and the saturated with a vitamm B 3 compound, 2) the vial is shaken and allowed to sit m a bath at 30°C for 1 hour A small stir bar is used to agitate the contents of the vial If no precipitation occurs m the vial, then more niacinamide is added This was repeated until precipitation occurred The sample is left m the bath for an additional 48 hours to insure saturation, 3) the saturated emollient is drawn mto a syringe, 4) A 045 micron filter (Gelman Acrodisc) is fitted on the end the syringe and the emollient is filtered through mto separate pre-weighted vial for analysis, 5) The emollient is analyzed usmg HPLC to determine the amount of niacinamide therein II Analysis Approximately 0 25g of the sample is weighed (sample weight) mto a 15mL plastic screw-cap centπfuge tube The sample is mixed with approximately 3mL of 50/50 v/v methanol/chloroform and homogenized by vortex mixing About 7mL of water is then added to extract the vitamm B 3 compound from the methanoL/chloroform phase Each sample is mixed by shaking 50 times m a back and forth motion to facilitate transfer of the niacinamide from the methanol/chloroform to the water phase This mixing creates an emulsion at the interface of the two phases The emulsion can be dissipated by letting the sample stand for several hours or by bπef centnfugation (15 seconds) at high speed Once the two phases have completely separated, a pipette is used to carefully transfer the aqueous phase mto a separate, pre-weighted vial The weight of the aqueous phase is noted (aqueous phase weight) An aliquot of the aqueous phase is transfeπed to an analysis container and analyzed for niacinamide by HPLC (Waters 2690 Separations Module coupled with a Waters 996 PDA detector, both supplied by Waters Corporations) III Calculations The percent vitamm B 3 compound is determined by taking the vitamm B 3 compound concentration measured by HPLC and multiplying by the dilution factor The dilution factor is the aqueous phase weight divided by the sample weight EXAMPLES The cosmetic formulations illustrated m Examples I-X illustrate specific embodiments of the cosmetic compositions of the present invention, but are not mtended to be limiting thereof Other modifications can be undertaken by the skilled artisan without departmg from the spint and scope of this mvention These exemplified embodiments of the cosmetic compositions of the present mvention provide improve the skm penetration of the vitamm B 3 compound as well as improve the skm feel of the crystallme vitamm B3 compound All exemplified compositions can be prepared by conventional formulation and mixing techniques Such formulation and mixing techniques are descnbed in detail m Harry's Cosmeticology. pp 119-141 and 314-354 (J B Wilkinson and R J Moore 7 th ed 1982) and Cosmetics Science and Technology, pp 1-104 and 307-422 (M S Balsam and E Sagarm 2 nd ed 1972), both of which are herem incorporated by reference m their entirety Component amounts are listed as weight percents and exclude mmor matenals such as diluents, filler, and so forth The listed formulations, therefore, compπse the listed components and any mmor matenals associated with such components Example I-Lipstick Composition Ingredient Amount (weight percent) Ozokente Wax 5 00 Candelilla Wax 3 00 Caranauba Wax 2 00 Cetyl Alcohol 2.00 Cetyl Lactate 2.00 Ascorbyl Palmitate 0.50 Propylparaben 0.10 Vitamm E Acetate 0.05 Isopropyl Isostearate 13.97 Octyl Hydroxystearate 5.20 Paraffin Wax 2.50 2 Nιcotιnιc acid N-oxιde(23%) + castor 21 74 oιl(77%) Acetylated Lanolm 6.33 Mica SVA 1 10.00 Pigment Slurry (30%Pιgment/70%Castor oil) 25.61 Lauroyl lysme treated mica, Mearlmica SVA, supplied by Mearl In a suitable vessel, neat, chemically synthesized niacinamide is dissolved usmg an appropπate solvent (e.g , water, alcohol such as ethanol, polyhydnc alcohols and the like) The nicotinic acid N-oxide is then recrystallized by the smgle solvent method. The recrystallized nicotinic acid N-oxide is combined with the castor oil and milled to the appropnate particle size. Separately, the milled cylmdncal crystallme nicotinic acid N-oxide/castor oil mixture with the remammg mgredients of the above formulation are added to a vessel equipped with a heat source and heated to a temperature of about 90°C to form a melt. The melt is mixed until homogeneous. The mixture is deaerated by vacuum and poured mto the appropπate mold The mixture is cooled to ambient temperature and incorporated mto the appropriate package. The lipstick is applied to the lips to provide color, moistunzation and improved hp feel Example II-Lip tick Composition Ingredient Amount (weight percent) Ozokente Wax 5.00 Candelilla Wax 3.00 Camauba Wax 2.00 Cetyl Alcohol 2.00 Cetyl Lactate 2.00 Ascorbyl Palmitate 0.50 Propylparaben 0.10 Vitamm E Acetate 0.05 Isopropyl Isostearate 15.00 Octyl Hydroxystearate 10.00 Paraffin Wax 2.50 niacinamide 2.50 Castor oil 13.41 Acetylated Lanolm 6 33 Mica SVA 10.00 Pigment Slurry (30%Pιgment/70%Castor oil) 25.61 In a suitable vessel, neat, chemically synthesized niacinamide is dissolved us g an appropπate solvent. The niacinamide is then recrystallized by the binary solvent method Next, the recrystallized niacinamide is milled to the appropriate particle size. Separately, the milled cylmdncal crystallme niacinamide together with the remaining mgredients of the above formulation are added to a vessel equipped with a heat source and heated to a temperature of about 90°C to form a melt The melt is mixed until homogeneous. The mixture is deaerated by vacuum and poured mto the appropriate mold The mixture is cooled to ambient temperature and incorporated mto the appropnate package The lipstick is applied to the lips to provide color, moistunzation and improved p feel. Example Ill-Lipstick Composition Ingredient Amount (weight percent) Glycerine 0.300 Lecithin 2.00 Niacinamide 5.00 Octyl Palmitate 11.24 Isopropyl Palmitate 4.80 Bentone 38 1.00 Propylene Carbonate 0.33 Cetyl Recmolate 1.00 Dusopropyl Dimearate 29.88 Lanolm Oil 11.60 Ozokente 6.75 Candelilla 5.25 Be Square 175 2.00 PG-3 Dnsostearate 2.00 Vitamm "E" Acetate 0.05 Propylparaben 0.15 Methylparaben 0.15 Benzoic Acid 0 10 Pigments 9.00 Stamers 0.40 1 Non-treated mica, Mearlmica MMCF, supplied by Mearl In a suitable vessel, neat, chemically synthesized macinamide is dissolved usmg an appropπate solvent. The niacinamide is then recrystallized by the smgle solvent method and milled to the appropnate particle size and cylmdncal shape Next, the glycerine, lecithm and milled macinamide are mixed m an appropriate vessel until a liquid crystal phase is formed Separately, the remammg mgredients of the above formulation are added to a vessel equipped with a heat source and heated to a temperature of about 90°C to form a melt. The melt is mixed until homogeneous. The above liquid crystal phase mixture is added to the melt and mixed until homogeneous The mixture is dearated by vacuum and poured mto the appropnate mold. The mixture is cooled to ambient temperature and incorporated mto the appropriate package The lipstick is applied to the lips to provide color, moistunzation and unproved hp feel Example IV-Antiperspirant Gel Stick Ingredient Amount (weight percent) Niacinamide 4 N-Lauroyl-L-glutamic acid-di-n-butyl amide 1 4 12-hydroxysteanc acid 2 Light mineral oil 2 23 Dusopropyl Sebacate 3 39 Alummum Zirconium 25 Talc 3 OP-! supplied by Ajinomoto, Inc. 2 Benol White Mineral Oil supplied by Witco Chemical Corp. 3 Schercemol DIS supplied by Scher Cherfficals Inc. In a suitable vessel, neat, chemically synthesized niacinamide is dissolved using an appropriate solvent. The niacinamide is then recrystallized by the single solvent method. Next, the recrystallized niacinamide is milled to the appropriate particle size and cylindrical shape. Separately, the gelling agent, recrystallized niacinamide and the liquid base material are combined into a_ vessel equipped with a heat source. The mixture is heated to a temperature between about 80°C and about 130°C with stirring, until the mixture forms a homogeneous, molten solution. Preferably, the homogeneous, molten solution is allowed to cool to a mixing temperature; typically between about 65°C and 110°C. Next, the antiperspirant active and other ingredients are added to the melt, such as fragrances and colors, into the homogeneous, molten solution in the above vessel with stirring. The mixture is allowed to cool until it begins to thicken and poured into containers allowing them to cool to ambient temperature. (Although not preferred, the antiperspirant active may alternatively be added along with the gelling agent and the liquid base material in the first step.) An antiperspirant composition, comprised as above, is applied to the underarm area of a human subject, and reduces the perspiration in the applied area, improves odor in this area, and improves skin feel. Example V-Solid Antiperspirant Stick Ingredient Amount (weight percent) Niacinamide 8.0 Stearyl Alcohol 10.0 Hydrogenated Castor Oil-mp 86 degrees C. 4.0 Aluminum Chlorohydroxide 40.0 Isopar "V"' 37.0 Fragrance 1.0 100.0 '(Isopar "V" Avg. Mol. Wt. 197 B.P. Range, 255-301 degrees C.) - In a suitable vessel, neat, chemically synthesized niacinamide is dissolved using an appropriate solvent. The niacinamide is then recrystallized by the binary solvent method. Next, the recrystallized niacinamide is milled to the appropriate particle size and cylindrical shape. In separate vessel containing a heat source, the isoparaffin liquids, the water-insoluble liquid emollients, the surface active agent, and the water-insoluble waxes are heated to a temperature sufficient to form a solution of these materials. Next, the aluminum chlorohydroxide is added with gentle agitation, followed by the recrystallized niacinamide and remaining ingredients. The solution is mixed until a homogenous suspension is formed. The suspension is cooled to a temperature above the solidification point and is then poured into suitable containers. An antiperspirant composition, comprised as above, is applied to the underarm area of a human subject, and reduces the perspiration in the applied area, improves odor in this area, and improves skin feel. Example Vl-Solid Antiperspirant Stick Ingredient Amount (weight percent) Nicotinic acid 2.5 Steanc Acid 10.0 Hydrogenated Castor Oil-mp 86 degrees C. 4.0 Zirconium Chlorohydroxide 25.0 Talc 10.0 Isopar "M"' 42.5 Dusopropyl Adipate 5.0 Fragrance 1.0 100.0 '(Isopar "M", Avg. Mol Wt 191 B P Range, 207-260 degrees C ) - In a suitable vessel, neat, chemically synthesized niacinamide is dissolved usmg an appropnate solvent. The mcotmic acid is then recrystallized by the smgle solvent method Next, the recrystallized nicotinic acid is milled to the appropriate particle size and cylmdncal shape. In separate vessel contauung a heat source, the lsoparaffin liquids, the water-insoluble liquid emollients, the surface active agent, and the water-insoluble waxes are heated to a temperature sufficient to form a solution of these matenals. Next, the alummum chlorohydroxide is added with gentle agitation, followed by the recrystallized nicotinic acid and remammg mgredients The solution is mixed until a homogenous suspension is formed. The suspension is cooled to a temperature above the solidification pomt and is then poured into suitable contamers An antiperspirant composition, compnsed as above, is applied to the underarm area of a human subject, and reduces the perspiration in the applied area, improves odor m this area, and improves skm feel. Example Vll-Solid Antiperspirant Cream Ingredient Amount (weight percent) Niacinamide 3.0 cyclomethicone (D5) 40.5 dimethicone (350 cs) 4.0 Cab-O-Sιl HS-5 1 4 0 Mιcrothene FN510 2 6.0 Natrosol 3 2.0 lso-eicosane 4 13.0 Reach AZ 5 26.7 fragrance 0 8 'Colloidal silica thickening mateπal, sold by Cabot Corporation 2 Low density polyethylene powder, sold by U.S.I. Chemicals. - 3 Hydroxyethylcellulose, sold by Hercules, Inc. - 4 2, 2, 4, 4, 6, 6, 8, 8-dιmethyl-lO-methylundecane, obtamed from Permethyl Corporation, Frazier, PA - 5 Zιrcomum-alummum-glycme hydroxychloπde complex, particulate antiperspirant active matenal, sold by Reheis Chemical Company. - In a suitable vessel, neat, chemically synthesized macinamide is dissolved usmg an appropnate solvent The macmanude is then recrystallized by the bmary solvent method. Next, the recrystallized macinamide is milled to the appropnate particle size and cylmdncal shape. The cyclomethicone, dimethicone, iso-eicosane and perfume are added to a stainless steel mixing vessel The Cab-O-Sil is then added, followed by the Microthene and Natrosol and, finally, the annperspirant active and recrystallized macmanude The composition is thoroughly stirred after addition of each particulate matenal. The composition is then milled, usmg a Black & Decker Die Grmder (Model 4420, type 4) with a 6.35 cm diameter Cowles dispersing blade at approximately 6,000 rpm, for approximately 5 minutes. The penetration force value of the milled composition is approximately 300 grams at 25° C. and 50% relative humidity An antiperspirant cream formulation, compnsed as above, is applied to the underarm area of a human subject, and reduces the perspiration m the applied area, improves odor in this area, and improves skm feel. Example Viπ-Waterproof Mascara Ingredient Amount (weight percent) PetroleumDιstιllate ((IBP 345) 50.120 Glycerol Ester of Tall Oil Rosm 10.000 Bentone 38 CG or Type 5.890 Color(Black 34-3068 or Type) 5.000 Alkylated PVP (220 Type) 5.000 Tπhydroxysteann (R Type) 5.000 Magnesium Carbonate 309 5.000 Nicotinic acid N-oxide 5.000 Kaolm 2747 2.000 Camauba Wax, NF 2.000 Propylene Carbonate 1.940 Polyethylene AC-617A 1.000 Phenoxyethanol 0.250 Color( Yellow 34-3170 or Type) 1.600 Propylparaben, NF 0 100 Tenox BHA 0.100 Total 100.000 In a suitable vessel, neat, chemically synthesized nicotinic acid N-oxide is dissolved usmg an appropnate solvent. The mcotmic acid N-oxide is then recrystallized by the smgle solvent method Next, the recrystallized mcotmic acid N-oxide is milled to the appropnate particle size and cylmdncal shape. Next, the milled, recrystallized mcotmic acid N-oxide and the above ingredients except colorants and gellants/fillers are added mto stainless steel mixmg vessel equipped with a heating source. The mgredients are heated to a temperature of about 90°C and mixed usmg a propeller blade. Once the temperature reaches about 90°C, the mgredients are mixed usmg a dispersator blade at approximately 3500 rpm. The pigments are then slowly added during the mixmg with the dispersator Similarly, the gellants/fillers are added with mixmg The mixmg is continued with the dispersator until the mixture is homogeneous The mixture is then forced cooled while mixmg with the dispersator at 3500 rpm At about 40°C, mixmg is discontmued and the mixture is transfeπed mto an appropnate storage container. The mascara composition is applied to the lashes and/or eyebrows to provide softening, moistunzation, conditionmg and improved skm feel. Example IX-Mascara Ingredient Amount (weight percent) Petroleum Distillate (IBP 345) 52.120 Glycerol Ester of Tall Oil Rosm 10.000 Bentone 38 CG or Type 5.890 Magnesium Carbonate 309 5.000 Alkylated PVP (220 Type) 5.000 Tπhydroxysteann (R Type) 5.000 Talc 2755 4.790 Niacinamide 3.000 Kaolm 2747 2.000 Camauba Wax, NF 2.000 Propylene Carbonate 1.940 Polyethylene AC-617A 1.000 Phenoxyethanol 0.250 Propylparaben, NF 0 100 Tenox BHA 0.100 Color(Blue 3403516 or Type) 1.810 Total 100.000 The composition is prepared and used as in Example VIII. Example X-Mascara Ingredient Amount (weight percent) Petroleum Distillate (IBP 345) 51.220 Glycerol Ester of Tall Oil Rosm 10.000 Bentone 38 CG or Type 5.890 Magnesium Carbonate 309 5.000 Tπhydroxystseann (R Type) 5.000 Camauba Wax, NF 2 000 Niacinamide 10.000 Kaolm 2747 2.000 Propylene Carbonate 1.940 Polyethylene AC-617A 1.000 Phenoxyethanol 0.250 Color 5.500 Tenox BHA 0.100 Propylparaben, NF 0.100 Total 100.000 The composition is prepared and used as m Example VIII Example Xl-Lipstick INGREDIENT WT. % Polybutene 4.536 Lanolm Oil 18.342 Octoxyglyceryl Behenate 18.342 Stearyl heptanoate 8.856 Jojoba oil 8.856 castor oil 21.78 Butylated hydroxytoluene 0.054 Butylated hydroxyamsole 0.054 Microcrystallme Wax 6.84 Polyethylene 500 6.84 Niacinamide 4.5 (Amphiphiiic lipid phase) Lecithm 0.475 Cholesterol 0.475 dicetyl phosphate 0.05 In a suitable vessel, neat, chemically synthesized macmanude is dissolved usmg an appropπate solvent. The macmanude is then recrystallized by the smgle solvent method. Next, the recrystallized macmanude is combmed with the castor oil and milled to the appropπate particle size and cylmdncal shape. Separately, the milled cylmdncal crystallme niacinamide/castor oil mixture, polybutene, lanolm oil, octoxyglyceryl behenate, stearyl heptanoate, jojoba oil, butylated hydroxytoluene, butylated hydroxyamsole, microcrystallme wax, polyethylene 500 are added to a vessel equipped with a heat source and heated to a temperature of from about 100-110°C to form a melt. The melt is mixed until homogeneous. The lecithm, cholesterol and dicetyl phosphate are mixed separately under nitrogen and at a temperature of about 110°C The lecithm contauung mixture is then added to the macmanude contauung mixture and mixed until uniform The mixture is deaerated by vacuum and poured mto the appropnate mold. The mixture is cooled to ambient temperature and incorporated mto the appropnate package. The lipstick is applied to the lips to provide color, moistunzation and improved hp feel. Example Xπ-Lip Balm INGREDIENT WT. % SEFA Cottonate 84.000 Niacinamide 5.000 Candelilla Wax 3.000 Ozokente Wax 1.000 Microcrystallme Wax 1.500 Beeswax 5.300 BHT 0.050 Ethylene Brassylate 0.050 Propylparaben 0.100 100.000 In a suitable vessel, neat, chemically synthesized macmanude is dissolved usmg an appropnate solvent The macmanude is then recrystallized by the smgle solvent method Next, the recrystallized macmanude is mixed with SEFA Cottonate and nulled to the appropnate particle size and cylmdncal shape. The SEFA Cottonate/niacinamide mixture along with the remammg mgredients are added to a vessel equipped with a heat source and heated to a temperature of from about 80-90°C to form a melt. The melt is mixed until homogeneous. The mixture is deaerated by vacuum and poured mto the appropnate mold. The mixture is cooled to ambient temperature and incorporated mto the appropnate package. The hp balm is applied to the lips to provide moistunzation and improved hp feel Example XHI-Long-Lasting Cosmetic A long-lasting cosmetic accordmg to the present mvention is prepared as follows.. A. An admixture (Part A) is prepared by combining m a suitable vessel the following mgredients: INGREDIENT WT. % MQ Resin 1 43.7 PM99A 2 56.3 1 Tπmethylsiloxysihcate available from GE. 2 Isododecane available from Presperse. The admixture is mixed usmg conventional mixmg techmques until the MQ Resm is dissolved. Processmg B. An admixture (Part B) is prepared by combining m a suitable vessel the following ingredients- C INGREDIENT WT. % SE30 Silicone Gum 1 50 0 PM99A 50.0 1 Available from GE. The admixture is mixed usmg conventional mixmg techmques until the SE30 Silicone Gum is dissolved. C. A lipstick containing Part A and Part B is prepared by combining the following ingredients INGREDIENTS WT % 'Tocopherol mcotmate 1.00 Part A 47.00 Part B 24.91 Pιgment(s) 10.00 Propylparaben 0.20 PM99A 1.89 Bentone ISD 2 15.00 1 Cylmdncal crystallme tocopherol mcotmate with an average particle size of from 0.01% to about 50%>, by weight, havmg a particle size distribution such that at least about 70% of the crystallme particles have a height to width ratio greater than 1 2 10% bentone, 3% propylene glycol, 87%> Isododecane available from Rheox In a suitable vessel, the admixture of Part A along with the pigments, propylparaben, cylmdncal crystallme tocopherol mcotmate and PM99A are combmed and mixed usmg a Ross homogenizes at about 4,000 φms. for about 10 minutes or until the mixture is uniform (taking care not to ignite the PM99A). The Bentone ISD added to the mixture with mixing at about 4, 000 φms. until the mixture is uniform.. The admixture of Part B is added to the mixture and mixed initially at high shear, preferably 1600 φms., to facilitate dispersion using a IKA mixer. Once sufficient dispersion is achieved, the mixer speed is reduced, preferably to about 1,000 φms., and the mixture is allowed to mix until uniform. The mixture is then poured into a suitable container and tightly capped for storage, preferably at room temperature. The long lasting cosmetic composition is applied to the skin to provide color, moisturization and improved skin feel.

Claims: WHAT IS CLAIMED IS: 1 A lipstick composition contauung cylmdncal crystallme vitamm B3 compounds, and which provides improved skin feel, said composition comprising a) from about 0 01%) to about 50%, by weight, of cylmdncal crystallme vitamin B 3 compound particles havmg a particle size distnbution such that at least about 70%) of the crystallme particles have a height to width ratio greater than 1, and b) from about 1%> to about 90%>, by weight, of an emollient component, c) from about 1%> to about 90%>, by weight, of a sohdifymg agent, and d) from about 1% to about 90%, on an anhydrous basis, of a color A composition accordmg to Claim 1, wherem the particle size distnbution of the cylmdncal crystallme particles is such that at least about 50% of the crystallme particles have a height to width ratio of greater than about 2 A cosmetic composition accordmg to Claim 1, wherem said vitamm B3 compound is selected from macmanude, denvatives of macmanude, non-vasodilating esters of mcotmic acid, and combmations thereof A cosmetic composition accordmg to Claim 3, wherem said vitamm B3 compound is selected from macmanude, mcotmic acid N-oxide, and combmations thereof A cosmetic composition accordmg to Claim 4, wherem said vitamm B3 compound is macmanude A cosmetic composition accordmg to Claim 1, wherem said vitamm B3 compound is substantially free of salts of the vitamm B3 compound A cosmetic composition accordmg to Claim 1, wherem said vitamm B3 compound is substantially uncomplexed A cosmetic compositions accordmg to Claim 1, wherem said compositions is substantially free of polar solvents A cosmetic composition accordmg to claim 1, wherem said emollient compnses from about 10% to about 80% of the cosmetic composition 10. A cosmetic composition accordmg to claim 1, wherem the composition is anhydrous. 11 A cosmetic composition accordmg to claim 9, wherem the emollient is a non-polar emollient. 12 A cosmetic composition accordmg to claim 9, wherem the emollient compnses an oil component, said oil component compnsmg at least one oil and wherem at least 75% of the types of oils compnsmg the oil component have solubility parameters which do not differ by more than from about 0 1 to about 1 13. A cosmetic composition accordmg to claim 12, wherem said oil component is selected such that at least about 99% of the types of oils used have solubility parameters which do not differ by more than from about 0 1 to about 1.5 14. A cosmetic composition accordmg to claim 1, wherem said color compnses from about 1% to about 20% of the cosmetic composition. 15. A method of preparmg anhydrous cosmetic compositions, compnsmg the steps of: a.) dissolving and recrystallizmg synthesized vitamm B 3 compounds such that the cylmdncal vitamm B 3 crystals are formed; b.) filtering and drying the crystals from step a.); c.) milling the crystals of step b ) to form crystallme particles having a particle size distribution such that at least about 70% of the crystallme particles have a height to weight ratio at least 1 , d ) mcoφorating the crystals of step b.) mto a dermatologically acceptable, anhydrous cosmetic earner. 16. A method of preparmg anhydrous cosmetic compositions accordmg to Claim 15, wherem the method of recrystallization is selected from the group consistmg of evaporation from a smgle solvent, evaporation from a bmary mixture of solvents (volatile solvent and non-volatile solvent), batch crystallization, liquid-liquid diffusion, sitting-drop vapor-phase diffusion, hanging-drop vapor-phase diffusion, temperature change, gel crystallization sublimation and solidification. 17. A method of preparmg anhydrous cosmetic compositions accordmg to Claim 16, wherem the step of crystallizing the vitamm B 3 compound compnses dissolving chemically synthesized vitamin B 3 compound m a suitable solvent and recrystallizmg the vitamm B 3 compound. 18. A method of preparing anhydrous cosmetic compositions, comprising the steps of: a) combining vitamin B 3 compound with a cosmetic base comprising: i.) from about 1% to about 90%, by weight, of an emollient component comprising from 5% to about 90%, by weight, of an oil liquid at ambient temperature; ii.) from about 5% to about 50%, by weight, of a solidifying agent; iii.) sufficient polar solvent to solubilize at least about 1% of the vitamin B 3 compound; b) heating with mixing the compositions of step a.) until a homogenous liquid is formed; and c) cooling the mixture of step b) such that the vitamin B 3 compound recrystallizes into cylindrical crystalline particles having a particle size distribution such that at least 70% of the particles have a height to width ratio greater than 1. 19. A method of improving the perceived skin feel of vitamin B 3 compounds by applying to the skin a safe and effective amount of the composition in Claim 1. 20. A cosmetic composition which provides improved skin feel, said composition comprising: a) from about 0.01% to about 50%, by weight, of cylindrical crystalline vitamin B 3 compound particles having a particle size distribution such that at least about 70% of the crystalline particles have a height to width ratio greater than 1; and b) from about 1% to about 90%, by weight, of an emollient component. 21. A composition according to Claim 20, wherein said cylindrical crystalline vitamin B3 compound is niacinamide. 22. A composition according to Claim 20, wherein the composition is anhydrous. 23. A composition according to Claim 20, wherein the cylindrical crystalline vitamin B3 compound is dispersed in the emollient. 24. A composition according to Claim 20, wherein the composition is substantially free of polar solvents.

Inventors: JAKUBOVIC DAVID ANDREW, VATTER MICHAEL LEE, JAKUBOVIC, DAVID, ANDREW, VATTER, MICHAEL, LEE
Applicants: PROCTER & GAMBLE, THE PROCTER & GAMBLE COMPANY
Application year: 2000
Main classification: A61K7
IPC codes: A61K8, A61Q1, A61Q15