NOVEL CHALCONES

Abstract: Disclosed are novel chalcone derivatives having Formula (I). The compounds possess antiproliferative activity, and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the uterus, ovary or breast. The compounds of the invention may also be useful in the manufacture of a medicament for the treatment or prevention of menopausal disorders and osteoporosis.

Description: NOVEL CHALCONES The present invention relates to a novel class of compounds which have structures related to certain naturally occurring and synthetic chalcones, as well as to methods for the preparation of such compounds and to pharmaceutical uses thereof. The compound 1 ,3-diphenyl-2-propene-1-one is known by the trivial name "chalcone". Many naturally occurring flavonoids share structural features with chalcone and are referred to by the generic term "chalcones". Also, certain flavonoids, including ones which are also classified as chalcones, have recently been demonstrated to have anticancer activity (Cancer Research 48^ 5754, 1988) and chemopreventive activity in some tumours (J. Nat. Prod. 53, 23, 1990). In particular, quercetin, an ubiquitous flavonoid found in plants, has been shown to act on the proliferation of human leukaemic cells (Br. J. Haematology, 75, 489, 1990) and on other cell lines (Br. J. Cancer, 62, 94, 942, 1990; Int. J. Cancer, 46, 112. 1990; Gynaecologic Oncology, 45, 13, 1992) and to possess a synergic action with common antiblastic drugs. In addition, some natural or synthetic chalcones, described in our International Patent Publication No. WO 91/17749, and in International Patent Publication No. WO 96/19209 (Baylor College of Medicine), have proved to have a significant antiproliferation activity on a variety of different cell lines. Although the mechanism of action of the antiproliferative activity of flavonoids and chalcones is still unknown, it is believed to be linked to the interaction of these compounds with type II oestrogen receptors. The action in vivo of these polyphenol substances is certainly much more complicated. All these compounds are generally characterised by an almost complete insolubility in water and, in vivo, by a very poor bioavailabiiity linked to a rapid metabolism of phenols and a marked affinity for lipids and proteins. Surprisingly, it has now been found that certain novel chalcones, chalcone derivatives and chalcone analogues, and in particular, compounds in which the phenyl ring in the 1 -position is substituted or replaced by rings containing one or more heteroatoms, possess a greater antiproliferation activity both on sensitive cancerous cells and on cells which are resistant to common chemotherapeutic drugs, including the latest generation anti-neoplastic agents, paclitaxel and docetaxel. Thus according to one aspect of the present invention, there is provided a compound of Formula (I): or a pharmaceutically acceptable salt or solvate thereof wherein: Ar represents a substituted or unsubstituted, (preferably aromatic), carbocyclic or heterocyclic group, said carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents on the Ar group being independently selected from the group consisting of: (a) Cl, (b) Br, (c) F, (d) OH, (e) N0 2 , (f) CF 3 , (g) C 1-4 lower alky! (in particular CH 3 ), (h) SCH 3 , (i) NHCOCH 3 , 0 " ) N(R 6 )(R 8 ) wherein R 6 and R 8 are the same or different and each represents H or lower C^ alkyl, (k) OR 10 wherein R 10 represents a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from: Cl, Br, F, OMe, NO 2 and CF 3 , and (I) -OCOR 11 , wherein R 11 represents a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group or a phenyl group; R represents OH, OR 10 or OCOR 11 , wherein R 10 and R 11 are as defined above; and (A) R 2 and R 3 are each independently selected from: (i) a substituted or unsubstituted, preferably aromatic, carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents being independently selected from the group consisting of: Cl, Br, F, OH, NO 2 , CF 3 , C 1-4 lower alkyl (in particular CH 3 ), SCH 3 , NHCOCHa, N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 1 are as defined above, (ii) Cl, (iii) Br, (iv) F, (v) OH, (vi) NO 2 , (vii) a saturated or unsaturated lower C 1-4 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from Cl, Br, F, OMe, N0 2 and CF 3> (viii) NHCOCH 3 , (ix) N(R 6 )(R 8 ), (x) SR 10 , (xi) OR 10 , and (xii) OCOR 11 wherein R 6 , R 8 , R 10 and R 11 are as defined above; or (B) R 2 and R 3 taken together with the carbon atoms to which they are attached form a carbocyclic or heterocyclic ring having 5 or 6 ring atoms, any heteroatom being selected from N, O or S, said carbocyclic or heterocyclic ring being saturated or unsaturated, and being unsubstituted or substituted with one or more substituents selected from Cl, Br, F, OH, NO 2 , CF 3 , C 1-6 lower alkyl, SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined above. Compounds described above, wherein R 2 and R 3 taken together with the carbon atoms to which they are attached form a ring, may be represented by Formula (IA): wherein the substituents R and Ar are as defined above, and R 2 and R 3 taken together represent Ring Q, said Ring Q being a five- or six-membered, preferably aromatic, carbocyclic or heterocyclic ring, any heteroatom being selected from N, O, or S, said ring being unsaturated or saturated, said carbocyclic ring or heterocyclic ring may be unsubstituted or substituted with one or more substituents selected from: Cl, Br, F, OH, NO 2 , CF 3 , C 1-4 lower alkyl, SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined for Formula (I). Compounds of the invention having a structure Formula (IA) represent the xanthone derivatives of the present invention. The present invention also embraces compounds of Formula (I), wherein R and Ar are as defined for Formula (I) above and wherein R 2 and R 3 are each independently selected from: (i) a substituted or unsubstituted, preferably aromatic, carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents being independently selected from the group consisting of: Cl, Br, F, OH, NO 2) CF 3 , C M lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined above, (ii) Cl, (iii) Br, (iv) F, (v) OH, (vi) N0 2 , (vii) a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from Cl, Br, F, OMe, NO 2 and CF 3 , (viii) NHCOCH 3 , (ix) N(R 6 )(R 8 ), (x) SR 10 , (xi) OR 10 , and (xii) OCOR 11 wherein R 6 , R 8 , R 10 and R 1 are as defined above. Such compounds include flavone derivatives according to the present invention. One preferred class of compounds according to Formula (I) are those wherein Ar, R and R 3 are as defined in the above paragraph and wherein R 2 represents a substituted or unsubstituted, preferably aromatic, carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents being independently selected from the group consisting of: Cl, Br, F, OH, N0 2 , CF 3 , C 1-4 lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined as for Formula (I) above, represent flavone derivatives according to the present invention. Preferably for the above described compounds, R 3 is selected from the group consisting of: Cl, Br, F, OH, NO 2 , a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from: Cl, Br, F, OMe, NO 2 and CF 3 ; NHCOCH 3 , N(R 6 )(R 8 ), SR 10 , OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined for Formula (I) above. In a further preferred group of compounds according to the present invention, R 2 represents: a substituted or unsubstituted, preferably aromatic, carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents being independently selected from the group consisting of: Cl, Br, F, OH, NO 2 , CF 3 , d-» lower alkyl (in particular CH 3 ), SCH 3 , NHCOCHs, N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 0 and R 11 are as defined in Claim 1 ; and R 3 is selected from the group consisting of: Cl, Br, F, OH, N0 2 , a saturated or unsaturated lower C^ straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from: Cl, Br, F, OMe, N0 2 and CF 3 , NHCOCH 3 , N(R 6 )(R 8 ), SR 10 , OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined above. A further preferred group of compounds according to the present invention include compounds wherein R 3 is selected from: Cl, Br, F, OH, N0 2 , CF 3 , C M lower alkyl, SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 , and OCOR 11 wherein R 6 , R 8 , R 10 and R 1 are as defined for Formula (I) above. A particularly preferred R 3 group is C 1-4 lower alkyl, especially methyl. In a further preferred class of compounds, R 2 preferably represents a substituted or unsubstituted (preferably aromatic) carbocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, and any substituents are independently selected from the group consisting of: Cl, Br, F, OH, N0 2 , CF 3) C 1-4 lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined above. Of these, R 2 preferably represents an unsubstituted, preferably aromatic, carbocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings. An especially preferred R 2 group is phenyl. For the compounds of Formula (I), Ar preferably represents phenyl which may be unsubstituted or substituted with one or more substituents selected from the group consisting of Cl, Br, F, OH, N0 2 , CF 3 , C 1-4 lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 wherein R 6 , R 8 , R 10 and R 11 are as defined for Formula (I). Particularly preferred Ar groups include phenyl or phenyl substituted with 1 , 2 or 3 methoxy groups. For the Ar, R 2 and R 3 groups of Formula (I), the R 10 and R 11 groups are preferably a saturated or unsaturated C^ straight chain or branched hydrocarbyl group. Particularly preferred groups include methyl, ethyl, n-propyl and iso-propyl. An especially preferred group is methyl. The group R of the compounds of the invention preferably represents the group OR 10 . Within this group of compounds, preferred OR 10 groups include -OCH 2 CH=CMe 2 , -OCH 2 CMe=CH 2 , -OCH 2 CH=CH 2 and -OCH 2 C=CH. A further preferred group of compounds of the invention are compounds of Formula (I) wherein Ar represents phenyl, which may be unsubstituted or substituted by one, two or three substituents independently selected from Cl, Br, F, OMe, N0 2 , CF 3 , C lower alkyl (in particular CH 3 ), NMe 2 , NEt 2 , SCH 3 and NHCOCH 3 ; thienyl, 2-furyl, 3-pyridyl, 4-pyridyl or indolyl; and R represents OH or OCH 2 R 1 , wherein R 1 is selected from -CH=CMe 2 , -CMe=CH 2 , -CH=CH 2 and -C=CH. Within this group of compounds, Ar is preferably selected from trimethoxyphenyl, 3-pyridyl, 4-pyridyl and 3-indolyl, and R is preferably selected from OCH 2 CH=CMe 2 , OCH 2 CMe=CH 2 , OCH 2 CH=CH 2 and OCH 2 C=CH. In a preferred class of compounds, Ar contains a basic nitrogen function, for example, by virtue of a heterocyclic nitrogen ring atom being present, or Ar may contain a substituent having a basic nitrogen, such as an amine, or an acetamido function. Thus a preferred Ar group is a substituted or unsubstituted, preferably aromatic, heterocyclic group, said heterocyclic group containing from 5 to 10 ring atoms, at least one of which is a nitrogen atom, said ring atoms forming one or two rings, with the or each ring containing 5 or 6 ring atoms, wherein any substituent on the ring is as defined as for Formula (I). A further preferred group of compounds is wherein the group Ar is substituted with at least one substituent selected from NHCOCH 3 or N(R 6 )(R 8 ), wherein R 6 and R 8 are the same or different and each represents H or lower C 1-4 alkyl. Particularly preferred Ar groups containing a basic nitrogen function include of 3-pyridyl, 4-pyridyl, 3-indolyl, 4-dimethylaminophenyl and 4-acetamidophenyl. It will be appreciated that compounds of Formula (I) which contain a basic amino function may be converted to acid addition salts, with pharmacologically acceptable acids, e.g. hydrochloric acid and phosphoric acid. Such salts are also included in the present invention. The present invention also provides the use of a compound of Formula (I) in the manufacture of an antiproliferative medicament. In particular, the compounds of the present invention may be useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the uterus, ovary or breast. In particular, the compounds may be useful for the manufacture of a medicament for the treatment of cancer cells that are resistant to paclitaxel and docetaxel. The compounds of Formula (I) may advantageously be used in combination therapies involving the combined use of a compound of Formula (I) and another anti-neoplastic agent, especially paclitaxel or docetaxel. The combination therapy may involve simultaneous or successive administration of a compound of Formula (I) and an anti-neoplastic agent. Such combination therapy forms a further aspect of the invention. The compounds of the invention may be further used in the manufacture of a medicament for the treatment or prevention of menopausal disorders and osteoporosis. The present invention further includes a pharmaceutical composition comprising one of more of the compounds of Formula I in combination with one or more pharmaceutically acceptable excipients. The invention will now be described by way of illustrative examples and with reference to the accompanying formulae drawings. EXAMPLES Example 1. General conditions to obtain chalcones. Method A. A solution of KOH 50% (3 ml) is added to an equimolar solution of acetophenone (0.0075 mol) and aldehyde (0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compounds are crystallized by ethanol or first separated by chromatography and then crystallized by ethanol. Method B. A solution of acetophenone (0.0075 mol), aldehyde (0.0075 mol), piperidine (15 ml) and acetic acid (75 ml) in ethyl alcohol 95% (80 ml) is countercurrent heated for 5 hours. Molecular sieves are added to the solution to eliminate water and the whole is left at rest for one night. The precipitate that is generally obtained is gathered and crystallized. If the product does not precipitate in these conditions, the solvent is vacuum evaporated and the residue is purified by chromatography on silica gel column. Example 2. 1-[3-(3-Methylbut-2-enyloxy)xanthen-9-one-4-yl]-3-phenyl- propen-1-one (see accompanying formula drawing VIB 176). A solution of KOH 50% (3 ml) is added to an equimolar solution of 3-(3- methylbut-2-enyloxy)-4-acetylxanthen-9-one (2.4 g, 0.0075 mol) and benzaldehyde (0.8 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.1 g of product m.p. 116-118 ° C, 1 H-NMR (CDCI3)δ:1.69 (s, 3H); 1.72 (s, 3H); 4.71 (d, 2H, J = 6.5); 5.38-5.40 (m, 1H); 7.05-7.10 (m, 2H); 7.08 (d, 1 H, J = 8.8 Hz); 7.10 (d, 1H, J = 16 Hz); 7.30-7.48 (m, 6H); 7.50-7.58 (m, 2H); 7.65-7.60 (m, 1 H) 8.30-8.33(m, 1H); 8.42 (d, 1 H, J = 8.9 Hz). Example 3. 1-[3-(3-Methylbut-2-enyloxy)xanthen-9-one-4-yl]-3-(3- methoxy-phenyl)-propen-1-one (see accompanying formula drawing VIB 177). A solution of KOH 50% (3 ml) is added to an equimolar solution of 3-(3- methylbut-2-enyloxy)-4-acetylxanthen-9-one (2.4 g, 0.0075 mol) and 3- methoxy-benzaldehyde (1.01 g, 0.0075 mol) in ethanol 95%, the addition being performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified. The precipitate is separated by filtration and dried under vacuum. The compound is crystallized with methanol to give 1.9 g of product m.p. 134-36 ° C, 1 H-NMR (CDCI 3 ) δ: 1 -69 (s, 3H); 1.72 (s, 3H); 3.84 (s, 3H); 4.71 (d, 2H, J = 6.5); 5.38- 5.40 (m, 1H); 6.95-6.98 (m, 1H); 7.05-7.15 ( m, 2H); 7.08 (d, 1H, J = 8.8 Hz); 7.09 (d, 1 H, J = 16 Hz); 7.23-7.42 (m, 4H); 7.65-7.72 (m, 1H); 8.32-8 (d, 1H, J = 8.8 Hz); 8.42(d, 1H, J = 8.9 Hz). Example 4. 1 -[3-(3-Methylbut-2-enyloxy)xanthen-9-one-4-yl]-3-(3,4,5-tri- methoxyphenyl)-propen-1-one (see accompanying formula drawing VIB 178). A solution of KOH 50% (3 ml) is added to an equimolar solution of 3-(3- methylbut-2-enyloxy)-4-acetylxanthen-9-one (2.4 g, 0.0075 mol) and 3, 4, 5- trimethoxy-benzaldehyde (1.47 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.2 g of product m.p. 153-55 ° C, 1 H NMR (CDCI 3 ) δ:1 -69 (s, 3H); 1.72 (s, 3H); 3.85-3.91 (m, 9H); 4.73 (d, 2H, J = 6.5); 5.38-5.40 (m, 1 H); 6.78 (s, 2H); 7.03 (d, 1H, J = 16 Hz); 7.09 (d, 1H, J = 8.8 Hz); 7.23-7.42 (m, 2H); 7.27 (d, 1H J=16 Hz); 7.80-7.87; (m, 1H) ; 8.32 ( d, 1H, J = 8.8 Hz); 8.44 (d, 1 H, J = 8.9 Hz). Example 5. 1-[3-(allyloxy)xanthen-9-one-4-yl] -3-phenyl-propen-1-one (see accompanying formula drawing VIB 175). A solution of KOH 50% (3 ml) is added to an equimolar solution of 3-allyloxy-4- acetylxanthen-9-one (2.2 g, 0.0075 mol) and benzaldehyde (0.8 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2 g of product m.p. 150-152 ° C, 1 H-NMR (CDCI 3 ) δ: 4.73^.74 (m, 2H); 5.25-5.42 (m, 2H); 5.92- 6.05 (m, 1H); 7.07 (d, 1H, J = 8.9 Hz); 7.13 (d, 1H, J = 16 Hz); 7.36-7.44 (m, 6H); 7.52-7.60(m, 2H); 8;31-8.36 (m, 1H); 8.43 (d, 1H, J = 8.9 Hz). Example 6. 1-[3-methyl-7-(3-methylbut-2-enyloxy)flavon-8-yl]-3-phenyl- propen-1-one (see accompanying formula drawing VIB 166). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(3- methylbut-2-enyloxy)-8-acetyl-3-methylflavone (2.71 g, 0.0075 mol) and benzaldehyde (0.8 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.3 g of product m.p. 83-84C, 1 H-NMR (CDCI 3 ) δ:1-67 (s, 3H); 1.70 (s, 3H); 2.18 ( 5, 3H); 4.68 (d, 2H, J = 6.4 Hz); 5.30-5.38 (m, 1 H); 7.00 (d, 1H, J =16 Hz); 7.02 (d, 1H, J = 8.9 Hz; 7.24 (d, 1H, J = 16 Hz); 7.30-7.45 (m, 6H); 7.48-7.54 (m, 4H);8.30 (d, 1 H , J = 8.9 Hz). Example 7. 1-[3-methyl-7-(3-methylbut-2-enyloxy)flavon-8-yl]-3-(3- methoxy)phenyl-propen-1-one (see accompanying formula drawing VIB 170). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(3- methylbut-2-enyloxy)-8-acetyl-3-methylflavone (2.71 g, 0.0075 mol) and 3- methoxy-benzaldehyde (1.01 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.2 g of product m.p. 134-36 ° C, 1 H-NMR (CDCI3) s:1.67 (s, 3H); 1.70 (s, 3H); 2.18 (s, 3H); 3.82 (s, 3H) 4.68 (d, 2H, J = 6.4 Hz); 5.30-5.38 (m, 1 H);6.93 (d, 1H, J = 16 Hz,); 6.96-7,18 (m, 3H);7.09 (d, 1H, J = 8,9 Hz); 7.20 (d, 1H, J = 16 Hz) 7,23-7.30 (m, 1H); 7.35-7.45 (m, 3H); 8.30 (d, 1H, J =8.9 Hz). Example 8. 1 -[3-methy l-7-(3-methy lbut-2-enyloxy)flavon-8-y l]-3-(3,4,5-tri- methoxy)phenyl-propen-1-one (see accompanying formula drawing VIB 173). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(3- methylbut-2-enyloxy)-8-acetyl-3-methylflavone (2.71 g, 0.0075 mol) and 3,4,5- trimethoxy-benzaldehyde (1.47 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2 g of product m.p.153-55 ° C, 1 H-NMR (CDCI 3 ) δ:1.70 (s, 3H); 1.72 (s, 3H); 2.18 (s, 3H); 3.86-3.91 (m, 9H); 4.70 (d, 2H, J = 6.4 Hz); 5.34-5.42 (m, 1H); 6.73 (s, 2H); 6.93 (d, 1H, J = 16 Hz); 7.09 (d, 1H, J = 8.9 Hz); 7.22 (d, 1H, J = 16 Hz); 6,96-7;18 (m, 3H); 7.52-7.58 (m, 2H); 8.32 (d, 1H, J = 8.9 Hz). Example 9. 1 -[3-methyl-7-(ally loxy)flavon-8-yl]-3-phenyl-propen-1 -one (see accompanying formula drawing VIB 164). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-allyloxy-8- acetyl-3-methylflavone (2.5 g, 0.0075 mol) and benzaldehyde (0.8 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.3 g of product m.p.145-47 ° C, 1 H-NMR (CDCI3) δ:1- 7 (s, 3H); 2.20 (s, 3H); 4.73 (d, 2H, J = 5.1 Hz); 5.25-5.45 (m, 2H); 5.91-6.02 (m, 1H); 7.05 (d, 1H, J = 16 Hz); 7.11 (d, 1H, J = 8.9 Hz); 7.38-7.48 (m ,7H); 7.53-7.59 (m, 4H); 8.34 (d, 1H, J = 8.9 Hz). Example 10. 1 -[3-methyl-7-(allyloxy)flavon-8-yl)-3-(3-methoxyphenyl)- propen-1-one (see accompanying formula drawing VIB 168). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-allyloxy-8- acetyl-3-methylflavone (2.5 g, 0.0075 mol) and 3-methoxy-benzaldehyde (1.01 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.4 g of product m.p.90-92 ° C, 1 H-NMR (CDCI 3 ) δ: 2.20 (s, 3H); 3.84 (s, 3H); 4.74 (d, 2H, J = 5,1 Hz); 5.1-5.3 (m, 2H); 5.91-6.02 (m, 1 H); 6.96-7.18 (m, 4H); 7.31 (d, 1 H, J = 16 Hz); 7.32-7.35 (m, 1H); 7.36-7.43 (m, 3H); 7.55-7.59 (m, 2H); 8.34 (d, 1H, J = 8.9 Hz). Example 11. 1-[3-methyl-7-(allyloxy)flavon-8-yl]-3-(3,4,5-trimethoxy- phenyl)propen-1-one (see accompanying formula drawing VIB 171). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-allyloxy-8- acetyl-3-methylflavone (2.5 g, 0.0075 mol) and 3,4,5-trimethoxy-benzaldehyde (1.47 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.4 g of product m.p.121-23 ° C, 1 H-NMR (CDCI 3 ) δ: 2.20 (s, 3H); 3.87 (m, 9H); 4.73 (d, 2H, J = 5,1 Hz; 5.25-5.45 (m, 2H); 5.91-6.02 (m, 1H); 6.75 (s, 2H); 6.96 (d,1H, J = 16 Hz); 7.10 (d, 1H, J = 8.9 Hz); 7.30 (d, 1H, J = 16 Hz); 7.42-7.46 (m, 3H); 7.55-7.59 (m, 2H); 8.34 (d, 1H, J = 8.9 Hz). Example 12. 1-[3-methyl-7-(2-methylallyloxy)flavon-8-yl]-3-phenylpropen- 1-one (see accompanying formula drawing VIB 165). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(2- methylallyloxy)-8-acetyl-3-methylflavone (2.61 g, 0.0075 mol) and benzaldehyde (0.8 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.8 g of product m.p.145-47 ° C, H-NMR (CDCI 3 ) δ:1 -78 (s, 3H); 2.20 (s, 3H); 4.62 (s, 2H); 4.98 (d, 2H, J = 18 Hz); 7.06 (d,1H, J = 16 Hz); 7.09 (d, 1 H, J = 8.9 Hz); 7.35-7.45 (m,7H); 7.50-7.55(m, 4H); 8.32 (d, 1H, J = 8.9 Hz). Example 13. 1-[3-methyl-7-(2-methylallyloxy)flavon-8-yl]-3-(3-methoxy- phenyl)-propen-1-one (see accompanying formula drawing VIB 169). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(2- methylallyloxy)-8-acetyl-3-methylflavone (2.61 g, 0.0075 mol) and 3-methoxy- benzaldehyde (1.01 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.4 g of product m.p. 131-34 ° C, 1 H-NMR (CDCI 3 ) δ: 1.76 (s, 3H); 2.20 (s, 3H); 3.82 (s, 3H) 4.62 (s, 2H); 5.05 (d, 2H, J = 18 Hz); 6.95-7.10 (m, 3H); 7.09 (d, 1H, J = 9 Hz); 7.10 (d, 1H, J = 9 Hz); 7.31 (d, 1H, J = 16 Hz); 7.40-7.45 (m,3H); 7.55-7.58 (m, 2H); 7.31 (s, 2H); 8.32 (d, 1H, J = 8.9 Hz). Example 14. 1 -[3-methyl-7-(2-methylallyloxy)flavon-8-yl]-3-(3,4,5-tri- methoxyphenyl)-propen-1-one (see accompanying formula drawing VIB 172). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(2- methylallyloxy)-8-acetyl-3-methylflavone (2.61 g, 0.0075 mol) and 3,4,5- trimethoxy-benzaldehyde (1.47 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.4 g of product m.p. 82-84 ° C, 1 H-NMR (CDCI 3 ) δ:1.76 (s, 3H); 2.20 (s, 3H); 3.82 (s, 3H); 4.62 (s, 2H); 5.05 (d, 2H, J = 18 Hz) ; 6.95-7.10 (m,3H); 7.09 (d,1H); 7.10 (d,1H, J = 9 Hz); 7.31 (d, 1H, J = 16 Hz); 7.40-7.45 (m,3H); 7.55-7.58 (m, 2H); 7.31 (s, 2H); 8.32 (d, 1H, J = 8.9 Hz). Example 15. 1-[3-methyl-7-(prop-2-ynyloxy)flavon-8-yl]-3-phenyl-propen-1- one (see accompanying formula drawing VIB 167). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(prop-2- ynyloxy)-8-acetyl-3-methylflavone (2.49 g, 0.0075 mol) and benzaldehyde (0.8 g, 0.0075 mol) in ethanol 95%. The addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.8 g of product m.p.157-59 ° C, 1 H-NMR (CDCI 3 ), 5: 2.20 (s, 3H); 2.56 (s, 1H); 4.86 (d, 2H, J = 2.2 Hz); 7.05 (d, 1H, J = 16 Hz); 7.23 (d, 1H, J = 8.9 Hz); 7.31-7.50 (m, 7H); 7.50-7.57 (m, H); 8,34 (d, 1H, J = 8.9 Hz). Example 16. 1-[3-methyl-7-(prop-2-yny1oxy)flavon-8-yl]-3- (3,4,5~trimethoxy-phenyl)propen-1-one (see accompanying formula drawing VIB 174). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(prop-2- ynyloxy)-8-acetyl-3-methylflavone (2.49 g, 0.0075 mol) and 3,4,5-trimethoxy- benzaldehyde (1.47 g, 0.0075 mol) in ethanol 95%. The addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.8 g of product m.p.152-54 ° C, 1 H-NMR (CDCI 3 ) δ÷ 2.02 (s, 3H), 2.56 (m, 1H); 3.86 (m, 9H); 4.86 (d, 2H, J = 2.2 Hz); 6.75 (s, 2H); 6.98 (d, 1 H, J = 16 Hz); 7.24-7.43 (m, 4H); 7.53-7.56 (m, 3H); 8.36 (d, 1H, J = 8.9 Hz). Example 17. 1-[3-methyl-7-(3-methylbut-2-enyloxy)flavon-8-yl]-3-(2- thienyl)-propen-1-one (see accompanying formula drawing VIB 238). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(3- methylbut-2-enyloxy)-8-acetyl-3-methylflavone (2.71 g, 0.0075 mol) and 2- thiophene-carboxyaldehyde (0.84 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.5 g of product m.p. 158-160°C, 1 H-NMR (CDCI 3 ) δ: 1 -58 (s, 3H), 2.07 (s, 3H), 4.6 (d, J=6.6 Hz, 2H), 5.3 (m, 1H), 6.65- 818 (m, 12H). Example 18. 1 -[3-methyl-7-methoxyflavon-8-yl]-3-(4-cyanophenyl)-propen- 1-one (see accompanying formula drawing VIB 247). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-methoxy- 8-acetyl-3-methylflavone (2.31 g, 0.0075 mol) and 4-cyanobenzaldehyde (0.98 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by ethanol to give 2.1 g of product m.p. 223-224°C, 1 H-NMR (CDCI 3 ) δ: 2.18 (s, 3H), 3.96 (s, 3H), 7.04- 8.36 (m, 13H). Example 19. 1 -(2-Methylallyloxy-xanthen-9-one-4-yl)-3-(4-fluorophenyl)- propen-1-one (see accompanying formula drawing VIB 245). A solution of KOH 50% (3ml) is added to an equimolar solution of 3-(2- methylallyloxy)-4-acetyl-xanthen-9-one (2.31 g, 0.0075 mol) and 4-fluoro- benzaldehyde (0.93 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.2 g of product m.p. 135-137°C, 1 H-NMR (CDCI 3 ) δ: 1.7 (m, 3H), 4.5 (m, 2H), 4.98 (m, 2H), 7.0-8.45 (m, 12H). Example 20. 1-(2-Allyloxy-xanthen-9-one-4-yl)-3-(4- methylthiophenyl)propen-1-one (see accompanying formula drawing VIB 244). A solution of KOH 50% (3 ml) is added to an equimolar solution of 3-(allyloxy)- 4-acetylxanthen-9-one (2.21 g, 0.0075 mol) and 4-methylthio-benzaldehyde (1.13 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.1 g of product m.p. 142-144°C, 1 H-NMR (CDCI 3 ) δ: 2.49 (s, 3H), 4.7 (d, 2H), 5.3 (m, 2H), 5.9 (m, 1 H), 7.03-8.41 (m, 12H). Example 21. 1-[3-methyl-7-(3-methylbut-2-enyloxy)fIavon-8-yl]-3-(4-chloro- phenyl)-propen-1-one (see accompanying formula drawing VIB 239). A solution of KOH 50% (3 ml) is added to an equimolar solution of 7-(3- methylbut-2-enyloxy)-8-acetyl-3-methylflavone (2.71 g, 0.0075 mol) and 4- chloro-benzaldehyde (1.05 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 1.9 g of product m.p. °C, 1 H-NMR (CDCI 3 ) ξ,: 1.69 (s, 3H), 1.72 (s, 3H), 2.19 (s, 3H), 4.65 (d, 2H), 5.31 (m, 1 H), 6.97-8.42 (m, 13H). Example 22. 1 -(2-Methy lally loxy-xanthen-9-one-4-y l)-3-(2,6-dichloro- phenyl)-propen-1-one (see accompanying formula drawing VIB 246). A solution of KOH 50% (3 ml) is added to an equimolar solution of 3-(2- methylallyloxy)-4-acetyl-xanthen-9-one (2.31 g, 0.0075 mol) and 2,6-dichloro- benzaldehyde (1.31 g, 0.0075 mol) in ethanol 95%; the addition is performed under energetic stirring at room temperature. The reaction is left under stirring for one night and then diluted with water and acidified; the precipitate is separated by filtration and dried under vacuum. The compound is crystallized by methanol to give 2.1 g of product m.p. 135-137°C, 1 H-NMR (CDCI 3 ) δ: 4.74 (m, 2H), 5.4 (m, 2H), 5.95 (m, 1H), 7.06-8.5 (m, 11H). BIOLOGICAL EVALUATION Compounds VIB 167, VIB 178 and VIB 173 were tested for their cytotoxicity against drug-resistant cancer cells, both alone, and in combination with paclitaxel. The results of these studies are shown below. When tested alone, compounds VIB 167, VIB 178 and VIB 173 were found to possess relatively low cytotoxicity (IC 50 > 1 μM) against drug-resistant cancer cells. The compounds were then evaluated in combination with paclitaxel for their cytostatic activity against the drug-resistant breast cancer cells MDA-435/LCC6-MDR. In the experiments, the compounds were used in combination with paclitaxel, the paclitaxel being at a concentration of 0.3 μM. Paclitaxel used alone possesses an IC 50 of 426 nM. However, as the results in Table 1 indicate, the IC 50 of paclitaxel decreases by 5-20 fold when used in combination with each of VIB 167, VIB 178 and VIB 173., i.e. from 426 nM to 82-21 nM, compared with paclitaxel alone. Consequently, in the presence of these compounds, paclitaxel can recover its excellent inhibitory activity against the drug-resistant cancer cells. Table 1 Experimental The treatment consisted of concurrent exposure of MDA-435/LCC-MDR cells to paclitaxel in the presence or absence of the compounds reversing agent (1 μM) for 72 h in vitro. Assessment of cytotoxicity, i.e. cell growth inhibition, was determined according to the methods of Skehan, et al. as discussed in J. Nat. Cancer Inst, 82, 1107, 1990. Briefly, cells were plated between 400 and 1200 cells/well in 96 well plates and incubated at 37°C for 15-18 h prior to drug addiction to allow attachment of cells. Compounds were solubilized in 100% DMSO and further diluted in RPMI-1640 containing 10 mM HEPES. After a 72 h incubation, 100 ml of ice- cold 50% TCA was added to each well and incubated for 1 h at 4°C. Plates were then washed 5 times with tap water to remove TCA, low-molecular weight metabolites and serum proteins. Sulforhodamine B (SRB) (0.4%, 50 ml) was added to each well. Following a five minute incubation at room temperature, plates were rinsed 5 times with 0.1% acetic acid and air dried. Bound dye was solubilized with 10 mM Tris Base (pH 10.5) for 5 min on a gyratory shaker. Optical density was measured at 570 nm. VIB 176 VIB 177 VIB 178 VIB 175 VIB 166 VIB 170 VIB 173 VIB 164 VIB168 VIB 171 VIB 165 VIB 169 VIB 172 VIB 167 VIB 174 VIB 238 VIB 239 VIB 247 VIB 244 VIB 246

Claims: CLAIMS 1. A compound of Formula (I): or a pharmaceutically acceptable salt or solvate thereof wherein: Ar represents a substituted or unsubstituted, (preferably aromatic), carbocyclic or heterocyclic group, said carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents on the Ar group being independently selected from the group consisting of: (a) Cl, (b) Br, (c) F, (d) OH, (e) N0 2 , (f) CF 3 , (g) C M lower alkyl (in particular CH 3 ), (h) SCH 3 , (i) NHCOCH 3 , Q) N(R 6 )(R 8 ) wherein R 6 and R 8 are the same or different and each represents H or lower C 1-4 alkyl, (k) OR 10 wherein R 10 represents a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1, 2 or 3 substituents selected from: Cl, Br, F, OMe, N0 2 and CF 3 , and (I) -OCOR 11 , wherein R 11 represents a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group or a phenyl group; R represents OH, OR 10 or OCOR 11 , wherein R 10 and R 11 are as defined above; and (A) R 2 and R 3 are each independently selected from: (i) a substituted or unsubstituted, preferably aromatic, carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents being independently selected from the group consisting of: Cl, Br, F, OH, N0 2 , CF 3 , C 1-4 lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined above, (ii) Cl, (iii) Br, (iv) F, (v) OH, (vi) N0 2 , (vii) a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from Cl, Br, F, OMe, N0 2 and CF 3 , (viii) NHCOCH 3 , (ix) N(R 6 )(R 8 ), (x) SR 10 , (xi) OR 10 , and (xii) OCOR 11 wherein R 6 , R 8 , R 10 and R 11 are as defined above; or (B) R 2 and R 3 taken together with the carbon atoms to which they are attached form a carbocyclic or heterocyclic ring having 5 or 6 ring atoms, any heteroatom being selected from N, O or S, said carbocyclic or heterocyclic ring being saturated or unsaturated, and being unsubstituted or substituted with one or more substituents selected from Cl, Br, F, OH, N0 2 , CF 3 , C 1-4 lower alkyl, SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined above. 2. A compound of Formula (I) according to Claim 1 having the structure (IA): wherein the substituents R and Ar are as defined for Claim 1 , and R 2 and R 3 taken together represent Ring Q, said Ring Q being a carbocyclic or heterocyclic ring having 5 or 6 ring atoms, any heteroatom being selected from N, O or S, said carbocyclic or heterocyclic ring being saturated or unsaturated and being unsubstituted or substituted with one or more substituents selected from: Cl, Br, F, OH, N0 2 , CF 3 , C 1-4 lower alkyl, SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined as for Claim 1. 3. A compound of Formula (I) according to Claim 1, wherein R and Ar are as defined for Claim 1 ; and R 2 and R 3 are each independently selected from: (i) a substituted or unsubstituted, preferably aromatic, carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents being independently selected from the group consisting of: Cl, Br, F, OH, N0 2 , CF 3 , C M lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined above, (ii) Cl, (iii) Br, (iv) F, (v) OH, (vi) N0 2 , (vii) a saturated or unsaturated lower Ci. 6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from Cl, Br, F, OMe, N0 2 and CF 3 , (viii) NHCOCH 3 , (ix) N(R 6 )(R 8 ), (x) SR 10 , (xi) OR 10 , and (xii) OCOR 11 wherein R 6 , R 8 , R 10 and R 11 are as defined in Claim 1. 4. A compound according to Claim 3 wherein R 2 represents a substituted or unsubstituted, preferably aromatic, carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents being independently selected from the group consisting of: Cl, Br, F, OH, N0 2 , CF 3 , C M lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined in Claim 1. 5. A compound according to Claim 3 wherein R 3 is selected from the group consisting of: Cl, Br, F, OH, N0 2 , a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from: Cl, Br, F, OMe, N0 2 and CF 3 ; NHCOCH 3 , N(R 6 )(R 8 ), SR 10 , OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined in Claim 1. 6. A compound according to Claim 3 wherein R 2 represents a substituted or unsubstituted, preferably aromatic, carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents being independently selected from the group consisting of: Cl, Br, F, OH, N0 2 , CF 3 , C- M lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined in Claim 1 ; and R 3 is selected from the group consisting of: Cl, Br, F, OH, N0 2 , a saturated or unsaturated lower C 1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1 , 2 or 3 substituents selected from: Cl, Br, F, OMe, N0 2 and CF 3 , NHCOCH 3 , N(R 6 )(R 8 ), SR 10 , OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined in Claim 1. 7. A compound according to any preceding claim wherein R 3 is selected from: Cl, Br, F, OH, N0 2 , CF 3) C 1-4 lower alkyl, SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 , and OCOR 11 wherein R 6 , R 8 , R 10 and R 11 are as defined in Claim 1. 8. A compound according to Claim 7 wherein R 3 is a C 1-4 lower alkyl group. 9. A compound according to Claim 8 wherein R 3 is methyl. 10. A compound according to any preceding claim wherein R 2 is a substituted or unsubstituted, preferably aromatic, carbocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, and any substituents are independently selected from the group consisting of: Cl, Br, F, OH, N0 2 , CF 3 , C 14 lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 , wherein R 6 , R 8 , R 10 and R 11 are as defined in Claim 1. 11. A compound according to Claim 10 wherein R 2 is an unsubstituted, preferably aromatic, carbocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms. 12. A compound according to Claim 11 wherein R 2 is phenyl. 13. A compound according to any preceding claim wherein R 0 and R 11 represents a saturated or unsaturated C 1-6 straight chain or branched hydrocarbyl group. 14. A compound according to Claim 13 wherein R 10 and R 1 are selected from methyl, ethyl, n-propyl and iso-propyl. 15. A compound according to any preceding claim wherein R represents -OCH 2 CH=CMe 2 , -OCH 2 CMe=CH 2 , -OCH 2 CH=CH 2 or -OCH 2 C=CH. 16. A compound according to any preceding claim wherein the group Ar represents phenyl which may be unsubstituted or substituted with one or more substituents selected from the group consisting of Cl, Br, F, OH, N0 2 , CF 3 , C 1-4 lower alkyl (in particular CH 3 ), SCH 3 , NHCOCH 3 , N(R 6 )(R 8 ), OR 10 and OCOR 11 wherein R 6 , R 8 , R 10 and R 11 are as defined as for Claim 1. 17. A compound according to any preceding claim wherein Ar represents phenyl or phenyl substituted with 1 , 2 or 3 methoxy groups. 18. A compound according to any preceding claim wherein Ar is selected from trimethoxyphenyl, 3-pyridyl, 4-pyridyl and 3-indolyl; and R is selected from OCH 2 CH=CMe 2 , OCH 2 CMe=CH 2 , OCH 2 CH=CH 2 and OCH 2 C=CH. 19. A compound according to any preceding claim wherein Ar represents phenyl, which may be unsubstituted or substituted by one, two or three substituents independently selected from Cl, Br, F, OMe, N0 2 , CF 3 , d_ 4 lower alkyl (in particular CH 3 ), NMe 2 , NEt 2 , SCH 3 and NHCOCH 3 ; thienyl, 2-furyl, 3-pyridyl, 4-pyridyl or indolyi. R represents OH or OCH 2 R 1 , wherein R 1 is selected from -CH=CMe 2 , -CMe=CH 2 , -CH=CH 2 and -C ≡ CH. 20. A compound according to any of Claims 1 to 15 wherein the group Ar is a substituted or unsubstituted, preferably aromatic, heterocyclic group, said heterocyclic group containing from 5 to 10 ring atoms, at least one of which is a nitrogen atom, said ring atoms forming one or two rings, with the or each ring containing 5 or 6 ring atoms, wherein any substituent on the ring is as defined as for Claim 1. 21. A compound according to any of Claims 1 to 15 wherein the group Ar is substituted with at least one substituent selected from NHCOCH 3 or N(R 6 )(R 8 ), wherein R 6 and R 8 are the same or different and each represents H or lower C 1-4 alkyl. 22. A compound according to any of Claims 1-15 wherein Ar is selected from the group consisting of 3-pyridyl, 4-pyridyl, 3-indolyl, 4-dimethyl- aminophenyl and 4-acetamidophenyl. 23. A compound of Formula (I) selected from the following: 1-[3-(3-methylbut-2-enyloxy)xanthen-9-one-4-yl]-3-phenyl-propen-1-one (VIB 176), 1-[3-(3-methylbut-2-enyloxy)xanthen-9-one-4-yl]-3-(3-methoxy-phenyl)-propen- 1-one (VIB 177), 1-[3-(3-methylbut-2-enyloxy)xanthen-9-one-4-yl]-3-(3,4,5-tri-methoxyphenyl)- propen-1-one (VIB 178), 1-[3-(allyloxy)xanthen-9-one-4-yl] -3-phenyl-propen-1-one (VIB 175), 1-[3-methyl-7-(3-methylbut-2-enyloxy)flavon-8-yl]-3-phenyl-propen-1-one (VIB 166), 1-[3-methyl-7-(3-methylbut-2-enyloxy)flavon-8-yl]-3-(3-methoxy)phenyl-propen- 1-one (VIB 170), 1 -[3-methyl-7-(3-methylbut-2-enyloxy)flavon-8-yl]-3-(3,4,5-tri-methoxy)phenyl- propen-1-one (VIB 173), 1-[3-methyl-7-(allyloxy)flavon-8-yl]-3-phenyl-propen-1-one (yiB 164), 1 -[3-methyl-7-(allyloxy)flavon-8-yl)-3-(3-methoxyphenyl)-propen-1 -one (VIB 168), 1 -[3-methyl-7-(allyloxy)flavon-8-yl]-3-(3,4,5-trimethoxy-phenyl)propen-1 -one (VIB 171), 1-[3-methyl-7-(2-methylallyloxy)flavon-8-yl]-3-phenylpropen-1-one (VIB 165), 1-[3-methyl-7-(2-methylallyloxy)flavon-8-yl]-3-(3-methoxy-phenyl)-propen-1-one (VIB 169), 1-[3-methyl-7-(2-methylallyloxy)flavon-8-yl]-3-(3,4,5-tri-methoxyphenyl)-propen- 1-one (VIB 172), 1-[3-methyl-7-(pro-2-ynyloxy)flavon-8-yl]-3-phenyl-propen-1-one (VIB 167) and 1 -[3-methyl-7-(pro-2-yny1 oxy)flavon-8-yi]-3-(3,4,5~trimethoxy-phenyl-propen-1 - one (VIB 174). 24. A compound of Formula (I) as defined in any preceding claim for use as an antiproliferative medicament. 25. Use of a compound of Formula (I) as defined in any preceding claim for the manufacture of a medicament for the treatment or prevention of neoplasms. 26. Use according to Claim 25 wherein the neoplasms are located in the uterus, ovary or breast. 27. Use according to Claim 25 or 26 of a compound of Formula (I) for the manufacture of a medicament for the treatment of paclitaxel- and docetaxel- resistant cancer cells. 28. Use according to any of Claims 25 to 27 of a compound of Formula (I) in the manufacture of an antiproliferative medicament for combination therapy. 29. Use according to any of Claims 25 to 28 of a compound of Formula (I) in the manufacture of an antiproliferative medicament in combination with one or more antineoplastic agents. 30. The use according to Claim 29 wherein the antineoplastic agent comprises paclitaxel or docetaxel. 31. The use according to Claim 25 in the manufacture of a medicament for the treatment or prevention of menopausal disorders and osteoporosis. 32. A pharmaceutical composition comprising one of more of the compounds of Formula (I) as defined in any preceding claim, in combination with one or more pharmaceutically acceptable excipients. 33. A pharmaceutical composition according to Claim 32 further comprising one or more antineoplastic agents. 34. A pharmaceutical composition according to Claim 32 wherein the antineoplastic agent is selected from paclitaxel or docetaxel.

Inventors: BOMBARDELLI EZIO, VALENTI PIERO, BOMBARDELLI, EZIO, VALENTI, PIERO
Applicants: BOMBARDELLI EZIO, INDENA SPA, VALENTI PIERO, BOMBARDELLI, EZIO, INDENA S.P.A., VALENTI, PIERO
Application year: 2000
Main classification: C07D311
IPC codes: A61K31, A61P15, A61P19, A61P35, C07D311, C07D409