CERTAIN ALKYLENE DIAMINE-SUBSTITUTED HETEROCYCLES

Abstract: The present invention also provides a general method to whereby mono-, bi-, or tri-cyclic heterocycles may be modified to obtain potent antagonists at the NPY1 receptor. The present invention provides novel, potent, non-peptidic antagonists of NPY receptors, particularly, the NPY1 receptors, designed from a selection of mono-, bi-, or tri-cyclic heterocyclic cores. This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those of formula (I)-(XV), wherein X is N or CR<14>; W is S, O, or NR<15>; Y is N or CR<3>; E, F, and G are each, independently, CR<3> or N; I and J are each, independently, C=O, S, O, CR<3>R<16> or NR<15> when single bonded to both adjacent ring atoms, or N, or CR<3> when double bonded to an adjacent ring atom; K is N or CR<3> when double bonded to L or J, or O, S, C=O, CR<3>R<16>, or NR<15> when single bonded to both adjacent ring atoms, or N or CR<3> when double bonded to an adjacent ring atom; L is N or CR<16> when single bonded to all atoms to which it is attached, or C (carbon) when double bonded to K; the 6- or 7-membered ring that contains I, J, K, and L may contain from 1 to 3 double bonds, from 0 to 2 heteroatoms, and from 0 to 2 C=O groups, wherein the carbon atom of such groups are part of the ring and the oxygen atom is a substituent on the ring; Q is O or NR<15>. Such compounds inhibit the activity of neuropeptide Y at those receptors are useful in treating physiological disorders associated with an excess of neuropeptide Y, including eating disorders, such as, for example, obesity and bulimia, and certain cardiovascular diseases, for example, hypertension.

Description: APPLICATION FOR UNITED STATES LETTERS PATENT IN THrTUNlTED STATES PATENT AND TRADEMARK OFFICE (Case No. U-012958-7) (FROM PROVISIONAL U012426-2) Title: Certain Alkylene Diamine-Substituted Heterocycles CerTain Alkylene Diamine-Substituted Heterocycles- Cross Reference to Related Application This application claims priority from Provisional Application 60/156870 filed on September 30, 1999 which is incorporated herein by reference. Field of the Invention This invention relates to certain alkylene diamine-substituted heterocycles which selectively and potently bind mammalian neuropeptide Y (NPY) receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating physiological disorders associated with an excess of neuropeptide Y, especially feeding disorders, some psychiatric disorders, and certain cardiovascular diseases. Background of the Invention Neuropeptide Y (NPY) is a 36 amino acid peptide first isolated in 1982 and subsequently found to be largely conserved across species. It belongs to a large family of peptides that includes, among others, peptide YY (PYY) and pancreatic peptide (PP). NPY is believed to be the most abundant peptide in the mammalian brain. It is also found in sympathetic neurons, and NPY-containing fibers have been found in peripheral tissues, such as around the arteries in the heart, the respiratory tract, the gastrointestinal tract, and the genitourinary tract. Central injection of NPY elicits a multitude of physiological responses, such as stimulation of feeding, increase in fat storage, elevation of blood sugar and insulin, anxiolytic behaviors, reduction in locomotor activity, hormone release, increase in blood pressure, reduction in body temperature, and catalepsy. In the cardiovascular system, NPY is believed to be involved in the regulation of coronary tone, while in the gastrointestinal tract, PYY is reported to cause inhibition of gastric acid secretion, pancreatic exocrine secretion, and gastrointestinal motility. These effects appear to be selectively mediated by various NPY receptors which currently include the Yi, Y 2 , Y 3 , Y , Y 5 , and Y subtypes, in addition to the hypothetical Yi-u e subtype. Selective peptidic agonists and antagonists have been identified for most of the subtypes, but few selective non-peptidic antagonists have been reported. The Yi and Y 5 receptor subtypes appear to be involved in appetite regulation, but their relative contribution to the modulation of food intake and energy expenditure remains unclear. The discovery of non-peptidic antagonists of the Yi and/or Y 5 receptor provides novel therapeutic agents, that are less prone to the shortcomings of the peptide antagonists, namely, for example, poor metabolic stability, low oral bioavailability, and poor brain permeability, for the treatment of obesity and cardiovascular disease. Summary of the Invention The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPYi receptor. The present invention provides novel, potent, non-peptidic antagonists of NPY receptors, particularly, the NPYi receptors, designed from a selection of mono- , bi-, or tri- cyclic heterocyclic cores. The heterocyclic cores encompassed by the compounds of formula II-XV (shown below) have been previously described. The modifications made to these heterocyclic cores to obtain potent and selective NPYi antagonists are entirely novel. Compounds that interact with the Yi receptor and inhibit the activity of neuropeptide Y at those receptors are useful in treating physiological disorders associated with an excess of neuropeptide Y, including eating disorders, such as, for example, obesity and bulimia, and certain cardiovascular diseases, for example, hypertension. This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those ofthe formula I-XV. II III IV V VI VII VIII IX X XI XII XIII XIV XV wherein X is N or CR 14 ; WisS, O,orNR 15 ; YisNorCR 3 ; E, F, and G are each, independently, CR 3 or N; I and J are each, independently, C=O, S, O, CRR 16 or NR 15 when single bonded to both adjacent ring atoms, or N, or CR 3 when double bonded to an adjacent ring atom; Kis N or CR 3 when double bonded to L or J, or O, S, C=O, CR 3 R 16 , or NR 15 when single bonded to both adjacent ring atoms, or N or CR 3 when double bonded to an adjacent ring atom; L is N or CR 16 when single bonded to all atoms to which it is attached, or C (carbon) when double bonded to K; The 6- or 7-membered ring that contains I, J, K, and L may contain from 1 to 3 double bonds, from 0 to 2 heteroatoms, and from 0 to 2 C=O groups, wherein the carbon atom of such groups are part of the ring and the oxygen atom is a substituent on the ring; Q is O or NR 15 ; , ι R is selected from H, Cι-C 6 alkyl, C 3 -Cι 0 cycloalkyl, (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cyano, halo, Cι-C 6 haloalkyl, OR 7 , Cι-C 6 alkyl-OR 7 ; Cι-C 6 cyanoalkyl, NR 8 R 9 , C, -C 6 alkyl-NR 8 R 9 ; R 2 is H, Ci-Cό alkyl which optionally forms a C 3 -Cβ aminocarbocycle or a C 2 -C 5 aminoheterocycle with A or B, each optionally substituted at each occurrence with R 7 , C 3 -Cιo cycloalkyl, or (C3-C10 cycloalkyl) C C 6 alkyl; or R 2 and R 6 jointly form with the 2 nitrogen atoms to which they are bound a C 2 -C 5 aminoheterocycle optionally substituted at each occurrence with R 7 ; A is (CH 2 ) m where m is 1,2 or 3 and is optionally mono- or di-substituted on each occurrence with Cι-C 6 alkyl, C3-C10 cycloalkyl, (C3-C10 cycloalkyl) C1-C6 alkyl, Cι-C 6 alkenyl, Ci-Ce alkynyl, cyano, halo, C,-C 6 haloalkyl, OR 7 , Cι-C 6 alkyl-OR 7 ; Cι-C 6 cyanoalkyl, NR 8 R 9 , C,-C 6 alkyl-NR 8 R 9 , or A and B jointly form a C 3 -C ό carbocycle, optionally substituted at each occurrence with R 7 or, as mentioned above, A and R 2 jointly form a C -C 6 aminocarbocycle or a C 2 -C5 aminoheterocycle optionally substituted at each occurrence with R 7 ; B is (CH 2 ) n where n is 1,2 or 3 and is optionally mono- or di-substituted on each occurrence with Cι-C 6 alkyl, C 3 -Cι 0 cycloalkyl, (C 3 -C 10 cycloalkyl) C C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cyano, halo, C,-C 6 haloalkyl, OR 7 , C C 6 alkyl-OR 7 ; Cι-C 6 cyanoalkyl, NR 8 R 9 , Ci-Cβ alkyl-NR 8 R 9 , or, as mentioned above, B and A jointly form a C 3 -C 6 carbocycle, optionally substituted at each occurrence with R 7 or, as mentioned above, B and R 2 jointly form a C -C 6 aminocarbocycle or a C 2 -C 5 aminoheterocycle optionally substituted at each occurrence with R 7 ; R 3 and R 16 are selected independently at each occurrence from H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C 2 -Cό alkenyl, C 2 -C 6 alkynyl, cyano, halogen, C,-C 6 haloalkyl, OR 7 , Cι-C 6 alkyl-OR 7 , C,-C 6 cyanoalkyl, NR 8 R 9 , d-C 6 alkyl-NR 8 R 9 R 4 is selected from aryl or heteroaryl, each optionally substituted with 1 to 5 substituents independently selected at each occurrence from Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, C 3 -Cιo cycloalkenyl, (C 3 -Cιo cycloalkyl) alkyl, Cι-C 6 alkenyl, halogen, Ci-C δ haloalkyl, trifluromethylsulfonyl, OR 7 , C,-C 6 alkyl-OR 7 , NR 8 R 9 , C,-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , C,-C 6 alkyl-CONR 8 R 9 , COOR 7 , C,-C 6 alkyl-COOR 7 , CN, C,-C 6 alkyl- CN, SO 2 NR 8 R 9 , S0 2 R 7 , aryl, heteroaryl, heterocycloalkyl, 3-, 4-, or 5-(2-oxo-l,3- oxazolidinyl), with the proviso that at least one of the positions ortho or para to the point of attachment of the aryl or heteroaryl ring to the heterocyclic core is substituted; R 5 is selected from: C|-C 6 alkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, each of which is substituted with 1 to 5 groups independently selected at each occurrence from halo, C1-C 2 haloalkyl, OR 7 , cyano, NR 8 R 9 , CONR 8 R 9 , COOR 7 , S0 2 NR 8 R 9 , SO 2 R 7 , NR u COR l2 , NR π SO 2 R 7 ; Cι-C 6 arylalkyl, Ci-C ό heteroarylalkyl, C$-C 8 arylcycloalkyl, or Cs-C heteroarylcycloalkyl, where aryl is phenyl or naphthyl, and heteroaryl is 2-,3-, or 4-pyridyl, 2-, 4- or 5- pyrimidinyl, triazinyl, 1-, 2- or 4-imidazolyl, 2-, 4-, or 5-oxazol^ isoxazolyl, indolyl, pyrazolyl, quinolyl, isoquinolyl, 2-, 4-, or 5-thiazolyl, benzothiadiazolyl, 1-, 3- or 4- pyrazolyl, 1-, 3- or 4-triazolyl, 2-triazinyl, 2-pyrazinyl, 2-, or 3-furanyl, 2-, or 3- thienyl, 2-, or 3 -benzo thienyl, or 1-, 2- or 5-tetrazolyl, each of which is optionally substituted with 1 to 5 substituents independently selected at each occurrence from Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, C -Cι 0 cycloalkenyl, (C3-C10 cycloalkyl) Cι-C 6 alkyl, C,-C 6 alkenyl, halogen, C|-C 6 haloalkyl, trifluromethylsulfonyl, OR 7 , NR 8 R 9 , Cι-C 6 alkyl-OR 7 , Cι-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, SO 2 NR 8 R 9 , SO 2 R 7 , aryl, heteroaryl, heterocycloalkyl, 3-, 4-, or 5-(2-oxo-l,3-oxazolidinyl), with the proviso that 2 adjacent substituents can optionally form together a C 3 -Cιo cycloalkyl ring, a C 3 -Cιo cycloalkenyl ring or a heterocycloalkyl ring; C -Cιo cycloalkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C 3 -Cιo cycloalkenyl, C 2 -C 6 alkenyl, C 2 -C6 alkynyl, each of which is optionally with 1 to 6 substituents independently selected at each occurrence from Ci-Cδ alkyl, C 3 -Cιo cycloalkyl, C3-C10 cycloalkenyl, (C3-C10 cycloalkyl) C C 6 alkyl, C,-C 6 alkenyl, halogen, C,-C 6 haloalkyl, OR 7 , NR 8 R 9 , with the proviso that when two OR 7 or NR 8 R 9 substituents are geminally located on the same carbon R 7 is not H and they can form together a C 2 -C 4 ketal, oxazoline, oxazolidine, imidazoline, or imidazolidine heterocycle, Ci-Cβ alkyl-OR 7 , Cι-C 6 alkyl- NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, oxo, hydroximino, C,-C 6 alkoximino, SO 2 NR 8 R 9 , SO 2 R 7 , heterocycloalkyl, aryl, heteroaryl, where aryl or heteroaryl is optionally substituted with 1 to 5 substituents independently selected at each occurrence from Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, C 3 -C 10 cycloalkenyl, (C 3 -Cιo cycloalkyl) Ci-Cβ alkyl, C,-C 6 alkenyl, halogen, C C 6 haloalkyl, trifluromethylsulfonyl, OR 7 , NR 8 R 9 , Cι-C 6 alkyl-OR 7 , C,-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, SO 2 NR 8 R 9 , SO 2 R 7 , aryl, heteroaryl, heterocycloalkyl, 3-, 4-, or 5-(2-oxo-l,3-oxazolidinyl), with the proviso that 2 adjacent substituents can optionally form together a C 3 -C 1 0 cycloalkyl ring, a C 3 - 0 cycloalkenyl ring or a heterocycloalkyl ring; aryl or heteroaryl, optionally substituted with 1 to 5 substituents independently selected at each occurrence from halogen, Ci- alkyl, C 3 -Cιo cycloalkyl, C 3 -Cιo cycloalkenyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, Ci-C δ alkenyl, halogen, Cι-C 6 haloalkyl, trifluromethylsulfonyl, OR 7 , NR 8 R 9 , Cι-C 6 alkyl-OR 7 , C,-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, SO 2 NR 8 R 9 , SO 2 R 7 , aryl, heteroaryl, heterocycloalkyl, 3-, 4-, or 5-(2- oxo-l,3-oxazolidinyl), with the proviso that 2 adjacent substituents can optionally form together a C 3 -Cιo cycloalkyl ring, a C 3 -Cιo cycloalkenyl ring or a heterocycloalkyl ring; or 3- or 4-piperidinyl, 3-pyrrolidinyl, 3- or 4- tetrahydropyranyl, 3-tetrahydrofuranyl, 3- or 4- tetrahydropyranyl, 3-tetrahydrofuranyl, 3- or 4-tetrahydrothiopyranyl, 3- or 4-(l,l- dioxo) tetrahydrofhiopyranyl, l-azabicyclo[4.4.0]decyl, 8-azabicyclo[3.2.1]octanyl, norbornyl, quinuclidinyl, each optionally substituted with 1 to 5 substituents 7 7 independently selected at each occurrence from R , Cι-C 6 alkyl-OR , Cι-C 6 alkyl- NR 8 R 9 , CONR 8 R 9 , COOR 7 ; R° is selected from H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C 2 -C alkenyl, Cι-C 6 arylalkyl, Cι-C 6 heteroarylalkyl where aryl or heteroaryl are optionally substituted with 1 to 5 substituents independently selected at each occurrence from halogen, Cι-C 6 haloalkyl, OR 13 , NR 8 R 9 , C C 6 alkyl-OR 13 , C,-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, SO 2 NR 8 R 9 , SO 2 R 7 , or R 6 and R 2 , as mentioned above, jointly form, with the 2 nitrogen atoms to which they are bound, a -C 5 aminoheterocycle optionally substituted at each occurrence with R 7 ; R 7 is H, Ci-Ce alkyl, C 3 -Cιo cycloalkyl, C 3 -Cι 0 cycloalkenyl, (C3-C10 cycloalkyl) Cι-C 6 alkyl, C1-C3 haloalkyl, or heterocycloalkyl, Cι-C 8 alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, Cι-C 8 alkanoyl, aroyl, heteroaroyl, aryl, heteroaryl, Ci-Cβ arylalkyl or Ci-Cό heteroarylalkyl each optionally substituted with 1 to 5 substituents independently selected at each occurrence from halogen, C,-C 6 haloalkyl, OR 13 , NR 8 R 9 , Cι-C 6 alkyl-OR 13 , Cι-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 13 , CN, SO 2 NR 8 R 9 , SO 2 R 13 , with the proviso that when R 7 is SO 2 R 13 , R 13 cannot be H; R 8 and R 9 are independently selected at each occurrence from H, Cι-C 6 alkyl, C 3 - 0 cycloalkyl, C 2 -C 6 alkenyl, C 3 -C 1 0 cycloalkenyl, C2-C6 alkynyl, heterocycloalkyl, Ci- C 8 alkanoyl, aroyl, heteroaroyl, aryl, heteroaryl, Ci-C arylalkyl or Cι-C 6 heteroarylalkyl, or R and R , taken together, can form a C 3 -C6 aminocarbocycle or a C 2 -C 5 aminoheterocycle each optionally substituted at each occurrence with with Ci- C 6 alkyl, C 3 -Cι 0 cycloalkyl, C 3 -Cι 0 cycloalkenyl, (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl, Ci- C 3 haloalkyl, or heterocycloalkyl, Cι-C 8 alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, Cι-C 8 alkanoyl, aroyl, heteroaroyl, aryl, heteroaryl, Ci-C δ arylalkyl or C I -C G heteroarylalkyl; R u is selected from H, Cι-C 6 alkyl, C 3 -Cι 0 cycloalkyl, (C3-C10 cycloalkyl) Cι-C 6 alkyl; R 12 is selected from H, aryl, heteroaryl, Cι-C 6 alkyl, C 3 -C 1 0 cycloalkyl, (C3-C 1 0 cycloalkyl) Ci-Cβ alkyl, optionally substituted with OR 7 , NR 8 R 9 , C3-C6 aminocarbocycle, or C 2 - C 5 aminoheterocycle; R 13 is independently selected at each occurrence from H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, (C 3 - C 10 cycloalkyl) Cι-C 6 alkyl, C 2 -C6 alkenyl, C2-C6 alkynyl, Cι-C 6 haloalkyl, with the proviso that for SO 2 NR 8 R 9 , SO 2 R 13 , R 13 cannot be H; R 14 is H, Cι-C 6 alkyl, C 3 -C 10 cycloalkyl, (C3-C10 cycloalkyl) C C 6 alkyl, C 2 -C 4 alkenyl, C 2 - C 4 alkynyl, halo, or CN; R 15 is selected at each occurrence from H, Cι-C 6 alkyl, C3-C 10 cycloalkyl, (C 3 -C10 cycloalkyl) Ci-Ce alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 2 -C 6 alkyl-OR 7 , C 2 -C 6 cyanoalkyl, C 2 -C 6 alkyl-NR 8 R 9 ; or a pharmaceutically acceptable salt, hydrate, or prodrug thereof. Preferred compounds of the present invention are those where X is N or CH, R is H, Ci-Ce alkyl, C 3 -C, 0 cycloalkyl, or (C 3 -C 10 cycloalkyl) C,-C 6 alkyl; and R 6 is H, Ci- , alkyl, C 3 -Ci 0 cycloalkyl, or (C 3 -C 10 cycloalkyl) Cι-C 6 alkyl. Additional prefered compounds are those wherein R 6 is phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. Other preferred compounds are those wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. This invention also encompasses, in additional embodiments, the novel compounds of formula I-XV, and the salts and solvates thereof, as well as pharmaceutical formulations comprising a compound of formula I-XV, or a pharmaceutically acceptable salt or solvate thereof, in combination with one or more pharmaceutically acceptable carriers, excipients, or diluents thereof. This invention also encompasses methods to treat physiological disorders associated with an excess of neuropeptide Y, such as eating and cardiovascular disorders, which method comprises administering to a mammal in need of said treatment an effective amount of a compound ofthe formula I-XV. This invention also encompasses methods of selectively inhibiting binding of NPYi receptors, which comprises contacting a compound of formula I-XV with neuronal cells, wherein the compound is present in an amount effective to produce a concentration sufficient to inhibit binding of NPY] receptors in vitro. As such, the present invention also provides a method to convert heterocyclic cores of formula Ia to XVa where X, E, F, G, W, I, J, K, L, Q, R 1 , R 3 , R 4 , R 15 and R 16 are defined above, into compounds that potently and selectively interact with NPYi receptors by substituting the n-position of heterocycles of formula Ia - XVIa with a diamine group of formula N[R 2 ]-A-B-N[R 6 ]-R 5 where R 2 , A, B, R 6 , and R 5 are defined above. Detailed Description of the Invention This invention relates to certain alkylene diamine-substituted heterocycles which selectively and potently bind mammalian neuropeptide Y (NPY) receptors., those of formula I-XV, which are novel and useful neuropeptide Y receptor antagonists. In the present description, the compounds of formula I-XV may be generically described under formula A, where R 1 , R 2 , R 4 , R 5 , R 6 , X, Y, A, and B are defined above. A In certain situations, the compounds of formula I-XV may contain one or more asymmetric carbon atoms, so that the compounds can exist in different stereoisomeric forms. These compounds can be, for example, racemates or optically active forms. In these situations, the single enantiomers, i.e., optically active forms, can be obtained by asymmetric synthesis or by resolution of the racemates. Resolution of the racemates can be accomplished, for example, by conventional methods such as crystallization in the presence of a resolving agent, or chromatography, using, for example a chiral HPLC column. Representative compounds of the present invention, which are encompassed by formula I-XV, include, but are not limited to the compounds in Examples 1-56 and their pharmaceutically acceptable acid addition salts. In addition, if the compound ofthe invention is obtained as an acid addition salt, the free base can be obtained by basifying a solution of the acid salt. Conversely, if the product is a free base, an addition salt, particularly a pharmaceutically acceptable addition salt, may be produced by dissolving the free base in a suitable organic solvent and treating the solution with an acid, in accordance with conventional procedures for preparing acid addition salts from base compounds. Non-toxic pharmaceutical salts include salts of acids such as hydrochloric, phosphoric, hydrobromic, sulfuric, sulfinic, formic, toluenesulfonic, methanesulfonic, nitric, benzoic, citric, tartaric, maleic, hydroiodic, alkanoic such as acetic, HOOC-(CH 2 )n-COOH where n is 0-4, and the ike. Those skilled in the art will recognize ϋTwide variety of non- toxic pharmaceutically acceptable addition salts. The present invention also encompasses the acylated prodrugs of the compounds of formula I-XV. "Prodrugs" are considered to be any covalently bonded carriers which release the active parent drug of formula I-XV in vivo when such prodrug is administered to a mammalian subject. Prodrugs of the compounds of the invention are prepared by modifying functional groups present in the compounds in such a way that the modifications are cleaved, either in routine manipulation or in vivo to the parent compounds. Prodrugs include compounds wherein hydroxy, amine, or sulfhydryl groups are bonded to any group that, when administered to a mammalian subject, cleaves to form a free hydroxyl, amino, or sulfhydryl group, respectively. Examples of prodrugs include, . but are not limited to, acetate, formate, and benzoate derivatives of alcohol and amine functional groups in the compounds of formula I-XV; and the like. Those skilled in the art will recognize various synthetic methodologies which may be employed to prepare non-toxic pharmaceutically acceptable addition salts and acylated prodrugs ofthe compounds encompassed by formula I-XV. Where a compound exists in various tautomeric forms, the invention is not limited to any one of the specific tautomers. The invention includes all tautomeric forms of a compound. By "heteroatom" in the present invention is meant oxygen or sulfur, or a nitrogen atom optionally substituted by CpCβ lower alkyl, Ci-Cό arylalkyl, Ci-Cio cycloalkyl, (C3-C10 cycloalkyl) Cι-C 6 alkyl, C 2 -C 8 alkanoyl, C 1 - 5 sulfonyl. By "alkyl", "lower alkyl", or "Cι-C 6 alkyl" in the present invention is meant straight or branched chain alkyl groups having 1-6 carbon atoms, such as, for example, methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, pentyl, 2-pentyl, isopentyl, neopentyl, hexyl, 2-hexyl, 3-hexyl, and 3-methylpentyl. By "cycloalkyl", or "C 3 -C 10 cycloalkyl" in the present invention is meant alkyl groups having 3-10 carbon atoms forming a mono-, bi-, or polycyclic ring system, such as, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, norbornyl, and the like. By "(cycloalkyl)alkyl", "lower (cycloalkyl)alkyl", or (C 3 -C10 cycloalkyl) C,-C 6 alkyl in the present invention is meant a straight or branched alkyl substituent formed of 1 to 6 carbon atoms attached ϊcTa mono-, bi, or polycyclic ring system havif!^ -10 carbon atoms, such as, for example, cyclopropylmefhyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, cycloheptylmethyl, and the like. The term "C 2 -C ό alkenyl" in the present invention means hydrocarbon chains having 2 to 6 carbons in a straight or branched arrangement and containing one or more unsaturated carbon-carbon double bonds which may occur in any stable point along the chain, such as, for example, ethenyl, allyl, isopropenyl, and the like. By "cycloalkenyl" or "C 3 -Cιo cycloalkenyl" in the present invention is meant alkyl groups having 3-10 carbon atoms forming a mono-, bi, or polycyclic ring system having 3-10 carbon atoms and containing one or more carbon-carbon double bonds which may occur in any stable point in the ring, such as, for example, cyclopentenyl, cyclohexenyl, or cycloheptenyl. The term "C 2 -C 6 alkynyl" in the present invention means hydrocarbon chains having 2 to 6 carbons in a straight or branched arrangement and containing one or more unsaturated carbon-carbon triple bonds which may occur in any stable point along the chain, such as, for example, ethynyl, propargyl, and the like. The term "aryl" in the present invention means a monocyclic or bicyclic aromatic group having preferably 6 to 10 carbon atoms, such as, for example, phenyl or naphthyl. The term "heteroaryl" in the present invention means an aryl group in which one or more of the ring(s) carbon atoms have been replaced with a heteroatom. Such groups preferably have 4 to 10 carbon atoms and 1 to 4 heteroatoms, such as, for example, pyridyl, pyrimidinyl, triazinyl, imidazolyl, oxazolyl, isoxazolyl, indolyl, pyrrolyl, pyrazolyl, quinolinyl, isoquinolinyl, thiazolyl, benzothiadiazolyl, triazolyl, triazinyl, pyrazinyl, furanyl, thienyl, benzothienyl, benzofuranyl, tetrazolyl. The term "heterocyclyl", "heterocycle" or "heterocycloalkyl" in the present invention means a saturated or partially saturated heteroaryl group. By "Cι-C 6 arylalkyl" or "Ci-C ό heteroarylalkyl" in the present invention is meant a branched or straight-chain alkyl group having 1-6 carbon atoms and substituted on one of the carbon atoms by an optionally substituted aryl or heteroaryl ring, such as, for example, benzyl, phenethyl, mefhylpyridyl, ethylpyridyl, and the like. By "C 5 - arylcycloalkyl" in the present invention is meant cycTOalkyl groups having 5-8 carbon atoms and fused to an aryl group, such as, for example, 1,2,3,4 tetrahydronaphthalenyl, 2,3-dihydrobenzothienyl, or 2,3-dihydobenzofuranyl. By "C 5 -C 8 heteroarylcycloalkyl" in the present invention is meant cycloalkyl groups having 5-8 carbon atoms fused to a heteroaryl group, such as, for example, 1,2,3,4 tetrahydroquinolyl, 2,3-dihydrobenzothienyl, 2,3-dihydobenzofuranyl, or indolinyl. By "alkoxy", "Cι-C 6 alkoxy", or "Ci-Cό alkyloxy" in the present invention is meant straight or branched chain alkoxy groups having 1-6 carbon atoms, such as, for example, methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, tert-butoxy, pentoxy, 2-pentyl, isopentoxy, neopentoxy, hexoxy, 2-hexoxy, 3-hexoxy, and 3-methylpentoxy. By "cycloalkoxy", "C 3 -Cιo cycloalkoxy", or "C 3 -Cιo cycloalkyloxy" in the present invention is meant a group formed by an oxygen atom attached to a mono-, bi, or polycyclic ring system having 3-10 carbon atoms, such as, for example, cyclopropoxy, cyclobutoxy, cyclopentoxy, cyclohexoxy, or cycloheptoxy. By "(cycloalkyl)alkyloxy", "(C3-C 1 0 cycloalkyl) Cι-C 6 alkoxy", or "(C3-C10 cycloalkyl) Ci-C ό alkyloxy" in the present invention is meant a group formed by an oxygen atom attached to a 1-6 carbon chain linked to a mono-, bi, or polycyclic ring system having 3- 10 carbon atoms, such as, for example, cyclopropylmefhyloxy, cyclobutylmefhyloxy, cyclopentylmethyloxy, cyclohexylmethyloxy, cycloheptylmefhyloxy, and the like. By "C 3 -C 6 aminocarbocycle" is meant a cyclic amino group formed by a nitrogen contained in a ring having 3 to 6 carbon atoms, such as, for example, azetidino, pyrrolidino, piperidino, perhydroazepino. By "C 2 -C 5 aminoheterocycle" is meant a cyclic amino group formed by a nitrogen contained in a ring having 2 to 5 carbon atoms and one other heteroatom, such as, for example, morpholino, fhiomorpholino, piperazino. By the terms "halo" or "halogen" in the present invention is meant fluoro, chloro, bromo, and iodo. "Haloalkyl" is intended to include both branched and straight-chain alkyl having the specified number of carbon atoms substituted with 1 or more halogens. The term "C 2 -C 8 alkanoyl" means an acyl group with 2 to 8 carbon atoms in a linear, branched, or C 3 - 0 cycloalkyl arrangement, optionally substituted with 1 to 5 substituents independently selected " at each occurrence from halogen, trifluoromethyl, OR 7 , NR 8 R 9 , CONR 8 R 9 , COOR 7 , or CN. The term "Cι-C 6 alkyl sulfonyl" means an alkylsulfonyl group containing 1 to 6 carbon atoms in a linear, branched, or C 3 -C 7 cycloalkyl arrangement. The term "substituted" means that one or more hydrogen on the designated atom is replaced by the specified group, provided that the valence on the designated atom is not exceeded, and that a chemically stable compound results from the substitution. A stable compound is defined herein as one that can be isolated, characterized, and tested for biological activity. The term "oxo" (i.e. =O) indicates that two geminal hydrogen atoms are replaced by a double-bond oxygen group. By "heterocyclic core" in the present invention is meant one of the following structures of formula Ia to XVa, where X, E, F, G, W, I, J, K, L, Q, R 1 , R 3 , R 4 , R 15 and R 16 are defined above. Va Via Vila Villa Xllla XlVa XVa In the present invention, some of the groups specifically mentioned above are defined as follows : O JJ 2-one-l,3-oxazolidinyl is ? N l-aza-bicyclo[4.4.0]decyl is 8-azabicyclo[3.2.1]octanyl is (1,1-dioxo) tetrahydrothiopyranyl is norbornyl is quinuclidinyl is Unless specified, the point of attachment may occur in any stable point along the above-mentioned rings. In the present invention, the term "potent" in the context of NPYI receptor antagonists qualifies a binding affinity with a Ki of less than 10 micromolar, preferably less than 1 micromolar, and more preferably less than 100 nanomolar in the human NPYI binding assay. In the present invention, the term "selective" in the context of NPYI receptor antagonists qualifies a binding affinity with a Ki in the human NPYi binding assay that is 10- fold, preferably 100-fold, and more preferably 1000- fold, less than the Ki of the same compound measured in another receptor binding assay, in particular the NPY 5 and CRFi receptor binding assays. Binding assays for the NPY 5 and CRFi receptors have been described, for example, in J. Clin. Invest., 102, 2136 (1998) and in Endocrinology 116, 1653 (1985), respectively. As the compounds of formula I-XV are antagonists of the Yl receptor, they are of value in the treatment of a wide variety of clinical conditions which are characterized by the presence of an excess of neuropeptide Y. Thus, the invention provides methods for the treatment or prevention of a physiological disorder associated with an excess of neuropeptide Y, which method comprises administering to a mammal in need of said treatment an effective amount of a compound of formula I-XV or a pharmaceutically acceptable salt, solvate or prodrug thereof. The term "physiological disorder associated with an excess of neuropeptide Y" encompasses those disorders associated with an inappropriate stimulation of neuropeptide Y receptors, regardless of the actual amount of neuropeptide Y present locally. These physiological disorders may include: disorders or diseases pertaining to the heart, blood vessels or the renal system, such as vasospasm, heart failure, shock, cardiac hypertrophy increased blood pressure, angina, myocardial infarction, sudden cardiac death, arrhythmia, peripheral vascular disease, and abnormal renal conditions such as impaired flow of fluid, abnormal mass transport, or renal failure; conditions related to increased sympathetic nerve activity for example, during or after coronary artery surgery, and operations and surgery in the gastrointestinal tract; cerebral diseases and diseases related to the central nervous system, such as cerebral infarction, neurodegeneration, epilepsy, stroke, and conditions related to stroke, cerebral vasospasm and hemorrhage, depression, anxiety, schizophrenia, and dementia; conditions related to pain or nociception; diseases related to abnormal gastrointestinal motility and secretion, such as different forms of ileus, urinary incontinence, and Crohn's disease; abnormal drink and food intake disorders, such as obesity, anorexia, bulimia, and metabolic disorders; diseases related to sexual dysfunction and reproductive disorders; conditions or disorders associated with inflammation; respiratory diseases, such as asthma and conditions related to asthma and bronchoconstriction; and diseases related to abnormal hormone release, such as leutinizing hormone, growth hormone, insulin, and prolactin. See U.S. Patent 5,504,094. Pharmaceutical Preparations The compounds of general Formula I-XV may be administered orally, topically, parenterally, by inhalation or spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques. In addition, there is proviued a pharmaceutical formulation comprising a compound of general Formula I-XV and a pharmaceutically acceptable carrier. One or more compounds of general Formula I-XV may be present in association with one or more non-toxic pharmaceutically acceptable carriers and/or diluents and/or adjuvants and if desired other active ingredients. The pharmaceutical compositions containing compounds of general Formula I-XV may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsion, hard or soft capsules, or syrups or elixirs. Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from sweetening agents, flavoring agents, coloring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets contain the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets. These excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example, corn starch, or alginic acid; binding agents, for example starch, gelatin or acacia, and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate may be employed. Formulations for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin or olive oil. Aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydropropylme hylcellulose, sodium alginate, polyvinyl-pyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally-occurring phosphatide, for example, lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more preservatives, for example ethyl, or n-propyl p- hydroxybenzoate, one or more coloring agents, one or more flavoring agents, and one or more sweetening agents, such as sucrose or saccharin. Oily suspensions may be formulated by suspending the active ingredients in a vegetable oil, for example arachid oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavoring agents may be added to provide palatable oral preparations. These compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid. Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example sweetening, flavoring and coloring agents, may also be present. Pharmaceutical compositions of the invention may also be in the form of oil-in- water emulsions. The oily phase may be a vegetable oil, for example olive oil or arachid oil, or a mineral oil, for example liquid paraffin or mixtures of these. Suitable emulsifying agents may be naturally-occurring gums, for example gum acacia or gum tragacanth, naturally- occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol, anhydrides, for example sorbitan monooleate, and condensation products ofthe said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monooleate. The emulsions may also contain sweetening and flavoring agents. Syrups and elixirs may be formulated with sweetening agents, for example glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavoring and coloring agents. The pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleaginous suspension. This suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above. The sterile injectable preparation may also be sterile injectable solution or suspension in a non-toxic parentally acceptable diluent or solvent, for example as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables. The compounds of general Formula I-XV may also be administered in the form of suppositories for rectal administration of the drug. These compositions can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug. Such materials are cocoa butter and polyethylene glycols. Compounds of general Formula I-XV may be administered parenterally in a sterile medium. The drug, depending on the vehicle and concentration used, can either be suspended or dissolved in the vehicle. Advantageously, adjuvants such as local anesthetics, preservatives and buffering agents can be dissolved in the vehicle. Dosage levels ofthe order of from about 0.1 mg to about 50 mg per kilogram of body weight per day are useful in the treatment of the above-indicated conditions (about 0.5 mg to about 3 g per patient per day), although in some circumstances higher amoounts, fo example upto 140 mg/kg/day may be appropriate. The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. Dosage unit forms will generally contain between from about 1 mg to about 500 mg of an active ingredient. Frequency of dosage may also vary depending on the compound used and the particular disease treated. However, for treatment of most eating disorders, a dosage regimen of 4 times daily or less is preferred. For the treatment of stress and depression a dosage regimen of 1 or 2 times daily is particularly preferred. It will be understood, however, that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, and rate " of excretion, drug combination and the severity of the particular disease undergoing therapy. Prefeπed compounds of the invention will have certain pharmacological properties. Such properties include, but are not limited to oral bioavailability, low toxicity, low serum protein binding and desirable in vitro and in vivo half-lives Penetration of the blood bram barrier for compounds used to treat CNS disorders is necessary, while low bram levels of compounds used to treat peπpheral disorders are often preferred Assays may be used to predict these desirable pharmacological properties Assays used to predict bioavailability include transport across human intestinal cell monolayers, including Caco-2 cell monolayers Toxicity to cultured hepatocytes may be used to predict compound toxicity Penetration of the blood brain barπer of a compound in humans may be predicted from the brain levels of the compound in laboratory animals given the compound intravenously Serum protein binding may be predicted from albumin binding assays Such assays are described in a review by Oravcova, et al (Journal of Chromatography B 1996, 677, 1- 27) Compound half-life is inversely proportional to the frequency of dosage of a compound In vitro half-lives of compounds may be predicted from assays of microsomal half-life as described by Kuhnz and Gieschen (Drug Metabolism and Disposition 1998, 26, 1120-1127). As discussed above, preferred compounds of the invention exhibit good activity in standard in vitro NPY receptor binding assays, specifically the assay as specified in Example 261, which follows References herein to "standard in vitro receptor binding assay" are intended to refer to that protocol as defined in Example 261 which follows Generally preferred compounds of the invention exhibit a K, of about 1 micromolar or less, still more preferably and K, of about 100 nanomolar or less even more preferably an K, of about 10 nanomolar or less or even 1 nanomolar or less in such a defined standard in vitro NPY receptor binding assay as exemplified by Example 261 which follows In appropπate case, the compounds of the invention may be employed in combination with other active agents The invention therefore also provides pharmaceutical combination compositions comprising a therapeutically effective amount of a composition comprising: (a) first compound, said first compound being a compound as described above a prodrug thereof, or a pharmaceutically acceptable salt of said compound or of said prodrug; and (b) a second compound, said second compound being a β 3 agonist, a thyromimetic, an eating behavior modifying agent or a NPY antagonist; and a pharmaceutical carrier, vehicle, diluent. To this end therefore the invention also provides a kit comprising: (a) first compound, said first compound being a compound as described above, a prodrug thereof, or a pharmaceutically acceptable salt of said compound or of said prodrug; (b) a second compound, said second compound being a β 3 agonist, a thyromimetic, an eating behavior modifying agent or a NPY antagonist; and a pharmaceutical carrier, vehicle, diluent; and (c) means for containing said first and second unit dosage forms wherein the amounts of the first and second compounds result in a therapeutic effect. Preparation of Alkylene Diamine-Substi tuted Heterocycles of Formula I-XV The preparation of these heterocyclic cores, identified in formula II-XV, can be carried out according to the methods described in the following references and those cited therein: Formula II : WO 9413676, WO 9534563, WO 9845295, EP 729758, J. Med. Chem., 40(11), 1749-1754 (1997), Bioorg. Med. Chem. Lett, 9(7), 967-972 (1999), J. Med. Chem., 42(5), 819-832 (1999) ; J. Med. Chem. 42(5), 833-848 (1999); Formula III: WO 9635689, WO 9729110, WO 9808847, WO 9847903, WO 9940091, US 5664057; Formula IV : WO 9413677, WO 9534563, EP 0729758; Formula V: WO 9533750, J. Med. Chem. 42(5), 833-848 (1999); Bioorg. Med. Chem. Lett., 9(7), 967-972 (1999); Formula VI : WO 9808847, WO 9829397; Formula VII: EP 239191, US 5273608; Formula VIII: US 5273608; Formula IX: WO 9510506, WO 9735539, WO 9808847, WO 9842706, J. Med. Chem. 42(5), 833-848 (1999); Formula X : WO 9808847, WO 9835967; Formula XI : WO 9533750, Bioorg. Med. Chem. Lett., 9(7), 967-972 u*99); Formula XII : WO 9808847, WO 9835967; Formula XIII : WO 9744038; Formula XIV : WO 9808846; WO 9829397, WO 9835967, WO 9847874, WO 9912908; Formula XV : WO 9510506, WO 9533750, WO 9714684, WO 9735580, WO 9842699, EP 778277, J. Med. Chem. 39(22), 4358-4360 (1996), J. Med. Chem. 42(5), 805-818 (1999), J. Med. Chem. 42(5), 833-848 (1999); An illustration of preparation methods of compounds ofthe present invention is given in the Schemes below. In particular displacement of a leaving group Z, as in formula 10 (scheme 1) by the appropriate substituted amine or appropriate substitution of an heterocyclic amino group, as in formula 21 (scheme 7), provides general methods to convert the heterocyclic cores of the present invention into compounds that potently interact with the NPY) receptor. Such transformations may require several consecutive chemical steps. Those having skill in the art will recognize that the starting materials may be varied and additional steps employed to produce compounds encompassed by the present invention. The disclosures of all articles and references mentioned in this application, including patents, are incoφorated herein by reference. SCHEME 1 10 A As illustrated in scheme 1, compounds of formula A can be prepared from intermediate compounds of formula 10, where Z is halogen (preferably chloro or bromo), alkane sulfonyloxy, aryl sulfonyloxy or haloalkane sulfonyloxy, and where R , R 2 , R , R , R , X, Y, A, and B are defined above, using the procedures outlined below. Compounds of formula 10 react with an amine of formula H 2 N-A-B-N[R 6 ]-R 5 , where A,B, R 5 and R 6 are defined as above, in the presence or absence of a base in the presence or absence of an inert solvent at reaction temperatures ranging from -78°^^o 250C° to generate compounds of formula A. Bases may include, but are not limited to, alkali metal hydrides (preferably sodium hydride), alkali metal alkoxides (1-6 carbons) (preferably sodium methoxide, sodium ethoxide, or sodium tert-butoxide), alkaline earth metal hydrides, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal bicarbonates, alkali metal bis-(trialkylsilyl)amides (preferably lithium or sodium (trirnefhylsilyl)amide), trialkylamines (preferably N,N-di-isopropyl-N-ethyl amine or triethylamine), arylamines (preferably 4-dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons) (preferably methanol, ethanol, or tert-butanol), lower alkanenitriles (1-6 carbons) (preferably acetonitrile), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1,4-dioxane), N,N-dialkylformamides (preferably dimethyl formamide), N,N-dialkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N- methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene), or haloalkanes (1-10 carbons and 1-10 halogens) (preferably CH 2 C1 2 ). Preferred reaction temperatures range from 0°C to 140°C. SCHEME 2 A Alternatively, as illustrate in scheme 2, compounds of formula A can be obtained by first reacting a compound of formula 10 with an amino alcohol of formula H 2 N-A-B-OH, where A and B are defined as above, in the presence or absence of a base in the presence or absence of an inert solvent at reaction temperatures ranging from -78°C to 250°C to generate intermediates of formula 11. Reacting a compound of formula 11 with a halogenating agent or sulfonylating agent in the presence or absence of a base in the presence or absence of an inert solvent at reaction temperatures ranging from -78°C to 250°C to afford products of formula 12a (where Z is halogen, alkane sulfonyloxy, aryl sulfonyloxy or haloalkane sulfonyloxy) or 12b when A and B are both CH 2 and X is CR 14 . Halogenating agents include, but are not limited to, SOCl 2 , POCl 3 , PC1 3 , PC1 5 , POBr 3 , PBr 3 , PBr 5 ., CCl 4 /PPh 3 . Sulfonylating agents include, but are not limited to, alkanesulfonyl halides or anhydrides (preferably methanesulfonyl chloride or methanesulfonic anhydride), aryl sulfonyl halides or anhydrides (such as p-toluenesulfonyl chloride or anhydride), or haloalkylsulfonyl halides or anhydrides (preferably trifluoromethanesulfonic anhydride). Bases may include, but are not limited to, trialkylamines (preferably N,N-di-isopropyl-N-ethyl amine or triethylamine), bicyclic amidines (preferably DBU), anilines (preferably N-dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, lower alkanenitriles (1 -6 carbons) (preferably acetonitrile), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1,4-dioxane), N,N- dialkylformamides (preferably dimethyl formamide), N,N-dialkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N-methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene), or haloalkanes with 1-10 carbons and 1-10 halogens (preferably CH 2 C1 ). Preferred reaction temperatures range from -20°C to 100°C. Compounds of formula 12a or 12b can then be reacted with an amine of formula HN[R 6 ]-R 5 , where R 5 and R 6 are defined as above, to give a compound of formula A Bases may include, but are not limited to, alkali metal hydrides (preferably sodium hydride), alkali metal alkoxides (1-6 carbons) (preferably sodium methoxide, sodium ethoxide, or sodium tert-butoxide), alkaline earth metal hydrides, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal bicarbonates, alkali metal bis-(trialkylsilyl)amides (preferably lithium or sodium (trimethylsilyl)amide), trialkylamines (preferably N,N-di-isopropyl-N-ethyl amine or triethylamine), arylamines (preferably 4-dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons) (preferably methanol, ethanol, or tert-butanol), lower alkanenitriles (1-6 carbons) (preferably acetonitrile), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), N,N-dialkylformamides (preferably dimethyl formamide), N,N-dialkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N- methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene), or haloalkanes (1-10 carbons and 1-10 halogens) (preferably CH C1 2 ). Preferred reaction temperatures range from 0C°C to 140°C. SCHEME 3 10 13 A1 A subset of compounds of formula A, described under formula Al (scheme 3), can be obtained by first reacting a compound of formula 10 with a diamine of formula H 2 N-A-B- NH 2 , where A and B are defined as above, in the presence or absence of a base in the presence or absence of an inert solvent at reaction temperatures ranging from -78°C to 250°C to generate intermediates of formula 13. Reaction of a compound of formula 13 with a ketone of Formula R a -C=0-R b in the presence of a reducing agent provides a compound of formula Al, where the grouping R a -CH-R b corresponds to R 3 in formula^., as defined above. Reducing agents include, but are not limited to, alkali metal or alkaline earth metal borohydrides (preferably lithium or sodium borohydride), borane (preferably complexed with dimethyl sulfide or tetrahydrofuran), dialkylboranes (such as di-isoamylborane), alkali metal aluminum hydrides (preferably lithium aluminum hydride), alkali metal (trialkoxy)aluminum hydrides (such as triethoxyaluminum hydride), dialkyl aluminum hydrides (such as di- isobutyl aluminum hydride), alane (preferably complexed with dimethyl amine). Inert solvents may include, but are not limited to, alkyl alcohols (1-6 carbons) (preferably methanol, ethanol, or tert-butanol), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), aromatic hydrocarbons (preferably benzene or toluene). Prefeπed reaction temperatures range from -78°C to 100°C. SCHEME 4 13 14 A2 Alternatively, a subset of compounds of formula A, described under formula A2 (scheme 4), can be obtained by first reacting a compound of formula 13 with an activated acid of formula R c -C=0-Z, where Z is halo (preferably chloro), O-acyl (preferably O-C=O- R c ), in the presence or absence of a base in the presence or absence of an inert solvent at reaction temperatures ranging from -78°C to 250°C to generate an amide intermediate of formula 14. Reaction of a compound of formula 14 with a reducing agent provides a compound of formula A2, where the grouping R C -CH 2 corresponds to R 5 in formula A, as defined above. Reducing agents include, but are not limited to, alkali metal or alkaline earth metal borohydrides (preferably lithium or sodium borohydride), borane (preferably complexed with dimethyl sulfide or tetrahydrofuran), dialkylboranes (such as di- isoamylborane), alkali metal aluminum hydrides (preferably lithium aluminum hydride), alkali metal (trialkoxyT iuminum hydrides (such as triethoxyalumΛWn hydride), dialkyl aluminum hydrides (such as di-isobutyl aluminum hydride), alane (preferably complexed with dimethyl amine). Inert solvents may include, but are not limited to, alkyl alcohols (1-6 carbons) (preferably methanol, ethanol, or tert-butanol), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1,4-dioxane), aromatic hydrocarbons (preferably benzene or toluene). Preferred reaction temperatures range from -78°C to 100°C. SCHEME 5 11 Alternatively, a subset of compounds of formula A, described under formula A3 (scheme 5), can be obtained by first reacting a compound of formula 10 with an amine of formula H 2 N-A- CH(OR c )(OR d ), where A is defined above, and R c and R d are C C 6 lower alkyls or, taken together, complete a ketal group, such as, for example a dioxane or dioxolane group, in the presence or absence of a base in the presence or absence of an inert solvent at reaction temperatures ranging from -78°C to 250°C to generate compounds of formula 15. Bases may include, but are not limited to, alkali metal hydrides (preferably sodium hydride), alkali metal alkoxides (1-6 carbons) (preferably sodium methoxide, sodium ethoxide, or sodium tert- butoxide), alkaline earth metal hydrides, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal bicarbonates, alkali metal bis- (trialkylsilyl)amides (preferably lithium or sodium (trime hylsilyl)amide), trialkylamines (preferably N,N-di-isopropyl-N-ethyl amine or triethylamine), arylamines (preferably 4- dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons) (preferably hefhanol, ethanol, or tert-butanol), lower alkanenitriles (1-6 carbons) (preferably acetonitrile), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), N,N- dialkylformamides (preferably dimethyl formamide), N,N-dialkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N-methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene), or haloalkanes (1-10 carbons and 1-10 halogens) (preferably CH 2 C1 2 ). Compounds of formula 15 react with a protic acid in the presence or absence of an inert solvent at reaction temperatures ranging from -78°C to 250°C, followed by aqueous work-up to generate compounds of formula 16. Inert solvents may include, but are not limited to dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), N,N- dialkylformamides (preferably dimethyl formamide), N,N-dialkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N-methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene), or haloalkanes (1-10 carbons and 1-10 halogens) (preferably CH 2 C1 2 ). Protic acids include, but are not limited to, formic acid, acetic acid, trifluoroacetic acid, hydrochloric acid, methane sulfonic acid. Alternatively, compounds of formula 16 can be obtained by oxidation of compounds of formula 11 where B= CH 2 . Oxidizing agents include, but are not limited to, transition metal oxides, such as CrO or Mn0 2 , pyridine-chromium complexes, such as Cr0 3 .C 5 H 5 N, pyridinium dichromate or pyridinium chlorochromate, or an oxalyl chloride- DMSO-triethylamine reagent (Swern oxidation). Compounds of formula 16 react with amines of formula H 2 N-R 5 , where R 5 is defined above, in the presence of a reducing agent in the presence or absence of an inert solvent in the presence or absence of a protic acid at temperatures ranging from -78°C to 100°C, to give compounds of formula A3. Reducing agents include, but are not limited to, alkali metal or alkaline earth metal borohydrides (preferably lithium or sodium borohydride), borane (preferably complexed with dimethyl sulfide or tetrahydrofuran), dialkylboranes (such as di-isoamylborane), alkali metal aluminum hydrides (preferably lithium aluminum hydride), alkali metal (trialkoxy)aluminum hydrides (such as triethoxyaluminum hydride), dialkyl aluminum hydrides (such as di-isobutyl aluminum hydride), alane (preferably complexed with dimethyl amine). Inert solvents may include, but are not limited to, alkyl alcohols (1-6 carbons) (preferably methanol, ethanol, or tert-butanol), dialkyl ' ^ethers (preferably diethyl ether), eyelid ethers (preferably tetrahydrofuran or 1 ,4-dioxane), aromatic hydrocarbons (preferably benzene or toluene). Compounds of formula 10, encompassing the heterocyclic cores of formula I-XV, are prepared according to procedures described in the references listed below. Compounds of formula 10a, used as starting material for the preparation of compounds of formula I, can be obtained according to scheme 6. SCHEME 6 Z = halogen E, F, G are defined above for X = CR 14 : 14 pro tic acid catalyst Compounds of formula 17, where E, F, and G are defined above and Z is a halogen, react with a compound of formula R 4 -CH 2 -CN, where R 4 is defined above, in the presence of base, in the presence or absence of an inert solvent, at reaction temperatures ranging from -78°C to 100°C, to generate compounds of formula 18. Bases may include, but are not limited to, alkali metal hydrides (preferably sodium hydride), alkali metal alkoxides (1-6 carbons) (preferably sodium methoxide, sodium ethoxide, or sodium tert-butoxide), alkaline earth metal hydrides, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal bicarbonates, alkali metal bis-(trialkylsilyl)amides (preferably lithium or sodium (trimethylsilyl)amide), trialkylamines (preferably N,N-di-isopropyl-N- ethyl amine or triethylamine), arylamines (preferably 4-dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons) (preferably methanol, ethanol, or tert-butanol), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), or dialkylsulfoxides (preferably dimethylsulfoxide). Preferred reaction temperatures range from 0°C to 100°C. Compounds of formula 18 then react with a compound of formula Z-CH 2 - COOR c , where Z is halogen (preferably chloro or bromo), alkane sulfonyloxy, aryl sulfonyloxy or haloalkane sulfonyloxy and R c is Cι-C 6 alkyl. in the presence of base, in the presence or absence of an inert solvent, at reaction temperatures ranging from -78 °C to 100°C, to generate compounds of formula 19. Bases may include, but are not limited to, alkali metal hydrides (preferably sodium hydride), alkali metal alkoxides (1-6 carbons) (preferably sodium methoxide, sodium ethoxide, or sodium tert-butoxide), alkaline earth metal hydrides, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal bicarbonates, alkali metal bis-(trialkylsilyl)amides (preferably lithium or sodium (trimethylsilyl)amide), trialkylamines (preferably N,N-di-isopropyl-N- ethyl amine or triethylamine), arylamines (preferably 4-dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons) (preferably methanol, ethanol, or tert-butanol), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), or dialkylsulfoxides (preferably dimethylsulfoxide). Preferred reaction temperatures range from 0°C to 100°C. Compounds of formula 20, where X is CR 14 and R 1 is defined above, can be obtained in two consecutive steps from compounds of formula 19 can be first reacted with a compound of formula R 1 C(OR c )-CH 2 -R 14 , where R c is methyl or ethyl, in the presence of base, in the presence or absence of an inert solvent, at reaction temperatures ranging from - 78°C to 100°C, to generate an non-isolated imine intermediate. Bases may include, but are not limited to, alkali metal hydrides (preferably sodium hydride), alkali metal alkoxides (1-6 carbons) (preferably sodium methoxide, sodium ethoxide, or sodium tert-butoxide), alkaline earth metal hydrides, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal bicarbonates, alkali metal bis-(trialkylsilyl)amides (preferably lithium or sodium (trimethylsilyl)amide), trialkylamines (preferably N,N-di-isopropyl-N- ethyl amine or triethylamine), arylamines (preferably 4-dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons^ (preferably methanol, ethanol, or tert-butanol), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), or dialkylsulfoxides (preferably dimethylsulfoxide) Preferred reaction temperatures range from 0°C to 100°C In a second step, the lmine intermediates are cychzed to a compound of formula 20 (X = CR 14 ) in the presence of base, in the presence or absence of an inert solvent, at reaction temperatures ranging from -78°C to 100°C Bases may include, but are not limited to, alkali metal hydrides (preferably sodium hydride), alkali metal alkoxides (1-6 carbons) (preferably sodium methoxide, sodium ethoxide, or sodium tert-butoxide), alkaline earth metal hydrides, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal bicarbonates, alkali metal bιs-(tπalkylsιlyl)amιdes (preferably lithium or sodium (tπmethylsιlyl)amιde), tπalkylamines (preferably N,N-dι-ιsopropyl-N- ethyl amine or triethylamine), arylamines (preferably 4-dimethyl aniline), or heteroaromatic amines (preferably pyπdme) Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons) (preferably methanol, ethanol, or tert-butanol), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1,4-dιoxane), or dialkylsulfoxides (preferably dimethylsulfoxide) Prefeπed reaction temperatures range from 0°C to l00°C Compounds of formula 20, where X is N and R 1 is defined above, can be obtained by reacting compounds of formula 19 with a compound of formula R'-C=0-R c , and R c is halogen, cyano, lower alkoxy (1-6 carbons), or lower alkanoyloxy (1-6 carbons), in the presence of a base in an inert solvent at reaction temperatures ranging from -78°C to 200°C Bases may include, but are not limited to, alkali metal hydndes (preferably sodium hydπde), alkali metal alkoxides (1-6 carbons) (preferably sodium methoxide, sodium ethoxide, or sodium tert-butoxide), alkaline earth metal hydndes, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal hydroxides, alkali metal bis- (tπalkylsιlyl)amιdes (preferably lithium or sodium (tnmethylsilyl) amide), trialkylamines (preferably N,N-dι-ιsopropyl-N-ethyl amine or tnethylamine), bicychc amidines (preferably DBU), or heteroaromatic amines (preferably pyndme) Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons) (preferably methanol, ethanol, or tert-butanol), lower alkanenitriles (1-6 carbons) (preferably acetonitπle), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), N,N-dιalkylformamιdes (preferably dimethyl formamide), N^N-dialkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N-methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene). Compounds of formula 10a, where Z is halogen, alkane sulfonyloxy, aryl sulfonyloxy or haloalkane sulfonyloxy and X is N, can be prepared by reacting a compound of formula 20 with a halogenating agent or sulfonylating agent in the presence or absence of a base in the presence or absence of an inert solvent at reaction temperatures ranging from -78°C to 250°C. Halogenating agents include, but are not limited to, SOCl 2 , POCl 3 , PC1 3 , PC1 5 , POBr 3 , PBr , or PBr 5 . Sulfonylating agents include, but are not limited to, alkanesulfonyl halides or anhydrides (preferably methanesulfonyl chloride or methanesul fonic anhydride), aryl sulfonyl halides or anhydrides (such as p- toluenesulfonyl chloride or anhydride), or haloalkylsulfonyl halides or anhydrides (preferably trifluoromethanesulfonic anhydride). Bases may include, but are not limited to, trialkylamines (preferably N,N-di-isopropyl-N-ethyl amine or triethylamine), bicyclic amidines (preferably DBU), anilines (preferably N-dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, lower alkanenitriles (1-6 carbons) (preferably acetonitrile), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1,4-dioxane), N,N-diaιkylformamides (preferably dimethyl formamide), N,N-dialkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N-methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene), or haloalkanes with 1-10 carbons and 1-10 halogens (preferably CH 2 C1 2 ). Preferred reaction temperatures range from -20°C to 100°C. Alternatively, some of the compounds of formula A can be obtained from compounds of formula 21, as illustrated in scheme 7. SCHEME 7 24 Compounds of formula 21 , where X, R , l' and R 4 are defined above, react with a compound of formula Z-B-(C=0)-R c , where B is defined above, Z is halogen (preferably chloro or bromo), alkane sulfonyloxy, aryl sulfonyloxy or haloalkane sulfonyloxy, and R c is halogen, cyano, lower alkoxy (1-6 carbons), or lower alkanoyloxy (1-6 carbons), in the presence or absence of a base, in the presence or absence of an inert solvent at reaction temperatures ranging from - 78°C to 200°C, to produce compounds of formula 22. Bases may include, but are not limited to, trialkylamines (preferably N,N-di-ιsopropyl-N-ethyl amine or triethylamine), bicyclic amidines (preferably DBU), anilines (preferably N-dimethyl aniline), or heteroaromatic amines (preferably pyπdine). Inert solvents may include, but are not limited to, lower alkanenitnles (1-6 carbons) (preferably acetonitrile), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1 ,4-dioxane), N,N-dialkylformamides (preferably dimethyl formamide), N,N-dιalkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N-methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene), or haloalkanes with 1-10 carbons and 1-10 halogens (preferably CH 2 C1 ). Preferred reaction temperatures range from -20°C to 100°C. Amides of formula 22 can be reacted with an amine of formula NH[R 6 ]R 5 , where R 6 and R 5 are defined above, in the presence or absence of a base, in the presence or absence of an inert solvent at reaction temperatures ranging from -78°C to 200°C, to produce compounds of formula 23. Bases may include, but are not limited to, alkali metal hydrides (preferably sodium hydride), alkali metal alkoxides (1-6 carbonsT" (preferably sodium methoxide, sodium ethoxide, or sodium tert-butoxide), alkaline earth metal hydrides, alkali metal dialkylamides (preferably lithium diisopropylamide), alkali metal carbonates, alkali metal bicarbonates, alkali metal bis-(trialkylsilyl)amides (preferably lithium or sodium (trimethylsilyl)amide), trialkylamines (preferably N,N-di-isopropyl-N-ethyl amine or triethylamine), arylamines (preferably 4-dimethyl aniline), or heteroaromatic amines (preferably pyridine). Inert solvents may include, but are not limited to, alkyl alcohols (1-8 carbons) (preferably methanol, ethanol, or tert-butanol), lower alkanenitriles (1-6 carbons) (preferably acetonitrile), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1,4-dioxane), N,N-dialkylformamides (preferably dimethyl formamide), N,N-dialkylacetamides (preferably dimethyl acetamide), cyclic amides (preferably N- methylpyrrolidin-2-one), dialkylsulfoxides (preferably dimethylsulfoxide), aromatic hydrocarbons (preferably benzene or toluene), or haloalkanes (1-10 carbons and 1-10 halogens) (preferably CH 2 C1 2 ). Preferred reaction temperatures range from 0°C to 140°C. Compounds of formula 23 can be reacted with a reducing agent in the presence or absence of an inert solvent to provide compounds of formula A, as defined above. Reducing agents include, but are not limited to, alkali metal or alkaline earth metal borohydrides (preferably lithium or sodium borohydride), borane (preferably complexed with dimethyl sulfide or tetrahydrofuran), dialkylboranes (such as di-isoamylborane), alkali metal aluminum hydrides (preferably lithium aluminum hydride), alkali metal (trialkoxy)aluminum hydrides (such as triethoxyaluminum hydride), dialkyl aluminum hydrides (such as di-isobutyl aluminum hydride), alane (preferably complexed with dimethyl amine). Inert solvents may include, but are not limited to, alkyl alcohols (1-6 carbons) (preferably methanol, ethanol, or tert-butanol), dialkyl ethers (preferably diethyl ether), cyclic ethers (preferably tetrahydrofuran or 1,4-dioxane), aromatic hydrocarbons (preferably benzene or toluene). Preferred reaction temperatures range from -78°C to 100°C. Alternatively, compounds of formula 22 can be reduced first, under experimental conditions similar to those used for the conversion of compounds of formula 23 to compounds of formula A, to generate compounds of formula 24. Compounds of formula 24 can then be reacted with compounds of formula NH[R δ ]R 5 , as defined above, under experimental conditions similar to those used for the conversion of compounds of formula 22 to compounds of formula 23, to generate compounds of formula A. Other compounds of formula 10 and of formula 21, used as starting material for the preparation of compounds of formula II-XV, can be obtained according to procedures described in the following references: Formula II : WO 9413676, WO 9534563, WO 9845295, EP 729758, J. Med. Chem., 40(11), 1749-1754 (1997), Bioorg. Med. Chem. Lett., 9(7), 967-972 (1999), J. Med. Chem., 42(5), 819-832 (1999) ; J. Med. Chem. 42(5), 833-848 (1999); Formula III: WO 9635689, WO 9729110, WO 9808847, WO 9847903, WO 9940091, US 5664057; Formula IV : WO 9413677, WO 9534563, EP 0729758; Formula V: WO 9533750, J. Med. Chem. 42(5), 833-848 (1999); Bioorg. Med. Chem. Lett., 9(7), 967-972 (1999); Formula VI : WO 9808847, WO 9829397; Formula VII: EP 239191, US 5273608; Formula VIII: US 5273608; Formula IX: WO 9510506, WO 9735539, WO 9808847, WO 9842706, J. Med. Chem. 42(5), 833-848 (1999); Formula X : WO 9808847, WO 9835967; Formula XI : WO 9533750, Bioorg. Med. Chem. Lett, 9(7), 967-972 (1999); Formula XII : WO 9808847, WO 9835967; Formula XIII : WO 9744038; Formula XIV : WO 9808846; WO 9829397, WO 9835967, WO 9847874, WO 9912908; Formula XV : WO 9510506, WO 9533750, WO 9714684, WO 9735580, WO 9842699, EP 778277, J. Med. Chem. 39(22), 4358-4360 (1996), J. Med. Chem. 42(5), 805-818 (1999), J. Med. Chem. 42(5), 833-848 (1999). EXAMPLES The following examples are which a provided to further illustrate the reaction schemes are not to be construed as limiting the invention. The preparation of the compounds of the present invention by the above-mentioned methods is illustrated further by the following examples and those delineated in the Tables which are not to be construed as limiting the invention in scope or spirit to the specific procedures and compounds described in them. Commercial reagents were used without further purification. THF refers to tetrahydrofuran. LDA refers to lithium diisopropylamide and DBU refers to l,8-diazabicyclo[5.4.0]undec-7-ene. Room or ambient temperature refers to 20°C to 25°C. Concentration implies the use of a rotary evaporator. TLC refers to thin layer chromatography. Mass spectral data were obtained either by CI or APCI methods. Commonly used abbreviations are: Ph is phenyl, Me is methyl, Et is ethyl, Pr is n-propyl, iPr is isopropyl, Bu is butyl, iBu is isobutyl (CH 2 -CHMe 2 ), tBu is tert-butyl, cBu is cyclobutyl, Pent is n-pentyl, cPent is cyclopentyl, cHex is cyclohexyl, Py is pyridyl, MeOH means methanol, EtOH means ethanol, EtOAc means ethyl acetate, Et 2 0 means diethyl ether, CH 2 CI 2 means methylene chloride, DMSO means dimethyl sulfoxide, NMP means N-methyl pyrrolidone, THF means tetrahydrofuran, DMF means dimethyl formamide, EX means example. The specific heterocyclic cores, generically described under formula A, are indicated in the table under Formula, which refers to the heterocyclic core defined in formula I-XV. EXAMPLE 1 A. 2-(2-Pyridinyl)-2-(2A6-trimethylphenyl)ethanenitrile Add dropwise over a period a mixed solution of 2-(2,4,6-trimetnylphenyl)ethanenitrile (20 g; 0.126 mol) and 2-bromopyridine (35 g; 0.22 mol) in DMSO (25 mL) to a solution of potassium t-butoxide (35 g; 0.31 mol) dissolved in DMSO (125 mL). After the addition, stir the mixture for 4 h at ambient temperature and slowly pour into a stirred, ice-cold solution of NH C1 with vigorous stirring. Filter the resulting tan precipitate, wash with MeOH, and air- dry to obtain the title compound as a pale yellow solid : 'H NMR (400MHz, CDC1 3 ) δ 2.30 (s, 6 H), 2.32 (s, 3 H), 5.76 (s, I H), 6.93 (s, 2 H), 7.12 (d, 1 H), 7.21 (dd, 1 H), 7.63 (t, 1 H), 8.63 (d, 1 H). B. Ethyl 2-amino-l -(2A6-trimethylphenyl)indohzine-3-carboxylate Slowly add dropwise ethyl bromoacetate (23mL; 0.21 mol) over a 3-hour period to a mixture of 2-(2-pyridinyl)-2-(2,4,6-trimethylphenyl)-ethanenitrile (22.3 g; 0.094 mol) and potassium carbonate (78 g; 0.57 mol) suspended in DMSO (100 mL). Stir the mixture for 1 day, pour into an aqueous NH 4 C1 solution (ca. 1 L), and extract with 3 X 200 mL of Et 2 O. Wash the combined extracts with saturated brine, dry over Na 2 S0 4 , filter, and concentrate in vacuo. Dissolve the residue in THF (200mL), cool to 0°C, and add slowly in portions potassium t- butoxide (12 g; 0.11 mol) over a 10-minute period. After 30 minutes at 0°C, dilute the mixture with aqueous NH C1 and extract with 2 X 150 mL of 50% Et 2 O in hexane. Wash the combined extracts with saturated brine, dry over Na SO 4 , filter, concentrate in vacuo, and purify by column chromatography on silica gel (eluent: 5 to 10% EtOAc in hexane) to obtain the title compound as an oil: 'H NMR (400MHz, CDC1 3 ) δ 1.47 (t, 3 H), 2.06 (s, 6 H), 2.35 (s, 3 H), 4.46 (br q, 2 H), 6.6 (br t, 1 H), 6.75 (d, 1 H), 6.9 (br t, 1 H), 7.00 (s, 2 H), 9.4 (1 H). C. 2-Methyl-9-(2.4,6-trimethylphenyl)pyrido[2,3-bl-indolizin-4-ol To a solution of 2-ethyl 2-amino-l-(2,4,6-trimethylphenyl)indolizine-3-carboxylate (19.2 g; 59.6 mmol) in 2,2-dimethoxypropane (lOOmL), add Λ-camphorsul fonic acid (0.2g). Stir the mixture at reflux for 30 min and then distill slowly to remove ca. 60 mL of volatiles over a 30-minute period. Cool the solution to ambient temperature under inert atmosphere, dilute with anhydrous toluene (50mL), and concentrate in vacuo. Dissolve the residue in toluene (50mL) and add dropwise over a 1-hour . period a 0.5 M solution of potassium bis(trimethylsilyl)amide in toluene (250 mL; 125 mmol) to the strrred solution. After the addition, stir the mixture for 2 h at ambient temperature, concentrate in vacuo to a small volume and dilute with aqueous NH 4 C1. Filter the resulting biphasic mixture and wash successively with water, MeOH, and Et 2 O. Dry under vacuum to obtain the title compound as a pale yellow solid. D. 4-Chloro-2-methyl-9-(2,4,6-trimethylphenyl)pyridino[2,3-b1-indolizine Heat at 100°C for 1 h a solution of 4-hydroxy-2-methyl-10-(2,4,6-trimethylphenyι)pyridino- [2,3-b]indolizine 2-methyl-9-(2,4,6-trimethylphenyl)pyrido[2,3-b]-indolizin-4-ol (10.1 g; 32 mmol) in phosphorus oxychloride (60 mL), cool to ambient temperature, and concentrate in vacuo. Partition the residue into ice water and CH 2 C1 2 . Separate the aqueous phase, extract twice with CH 2 CI2, and wash the combined organic extracts with a~I N aqueous sodium hydroxide solution and then with water. Dry the solution over Na2Sθ4, filter, and concentrate in vacuo. Filter the dark residue through a short pad of silica gel and wash with 25% EtOAc in hexane. Concentrate the filtrate in vacuo to obtain the title compound as a yellow solid : >H NMR (400MHz, CDC1 3 ) δ 2.00 (s, 6 H), 2.37 (s, 3 H), 2.64 (s, 3 H), 6.58 (t, 1 H), 6.95 (dd, 1 H), 7.00 (s, 2 H), 7.07 (s, 1 H), 7.08 (d, 1 H), 9.26 (d, 1 H). E. (2-Aminoethyl) 2-methyl-9-(2,4,6-trimethylphenyl)-pyridinor2.3-blindolizin-4-yllamine Heat a solution of 4-chloro-2-methyl-9-(2,4,6-trimethylphenyl)pyridino[2,3-b]-indolizine (0.35g, 1.04 mmol), and ethylene diamine (0.32 g, 1.04 mmol) in dry NMP (3mL) at 100 ° C for 5 h. Pour the cooled mixture onto water (30 mL) and extract twice with EtOAc (30 mL). Wash the combined extract with brine (30 mL), dry, and evaporate in vacuo. Purify by preparative TLC (20 % MeOH in CH 2 C1 2 with 1% ammonium hydroxide) to obtain the title compound as a colorless oil. F. 2-(4-Ethoxy-3-methoxy-phenyl)-N-{2-[2-methyl-9-(2,4.6-trimethyl-phenyl)-pyridinor2.3- b1indolizin-4-ylamino]-ethv -acetamide Treat a solution of (2-aminoethyl)[2-methyl-9-(2,4,6-trimethylphenyl)-pyridino[2,3- b]indolizin-4-yl]amine (0.08g, 0.22mmol), 4-ethoxy, 3 methoxy phenylacetic acid (0.05 g, 0.22 mmol) and N,N diisopropylethyl amine (0.04 mL, 0.24mmol) in CH 2 C1 2 (10 mL) with benzotriazol-l-yloxy-tris-(dimethylamino)phosphonium hexafluorophosphate (0.1 g, 0.24 mmol) and stir at ambient temperature for 14 h. Dilute the resulting mixture with CH 2 C1 2 (20 mL), water (20 mL), and saturated aq NaCl (20 mL). Dry the organic layer over Na 2 SO , filter and concentrate in vacuo. Purify by preparative TLC (10% MeOH in CH 2 C1 2 ) to obtain the title compound as a solid. G. (2- (r2-(4-Ethoxy-3-methoχyρhenyl)ethyl1aminol ethyl)r2-methyl-9-(2,4,6- trimeth ylphenvDp yridino [2,3 -b ~ ] indolizin-4-yl] amine Treat a solution of 2-(4-ethoxy-3-methoxy-phenyl)-N- {2-[2-methyl-9-(2,4,6-trimethyl- phenyl)-pyridino[2,3-b]indolizin-4-ylamino]-ethyl}-acetamide (0.08 g, 0.145 mmol) in THF (5 mL) with AlH 3 .NMe Et (3 mL, 1.45 mmol) and heat to reflux for 14 h. Cool the resulting mixture to ambient temperature, quench with Na 2 CO 3 .10H 2 0 (0.3 g) and stir at ambient temperature for 15 min. Filter the solution through Celite and wash with several portions of CH 2 C1 2 . Concentrate the filtrate in vacuo to dryness and purify by preparative TLC (10 % MeOH in CH 2 C1 2 with 0.5 % ammonium hydroxide) to the title compound as a solid. EXAMPLE 2 A. 2-Methyl-9-(2,4.6-trimethylphenyl pyrimidino[4,5-b1indolizin-4-ol Heat to 100°C for 1 h a solution of 2-amιno-3-cyano-l-(2,4,6-tπmethylphenyl)ιndolιzιne (220 mg) in an acetic anhydride (0 5 mL) - acetic acid (2 mL) mixture Cool the mixture to ambient temperature before concentrating in vacuo Heat the residue in 85% phosphonc acid (5mL) at 100°C for 1 5 h, allow to cool to ambient temperature, dilute with water, and neutralize to pH 7 by adding aqueous NaOH Extract the resulting yellow suspension twice with CH C1 2 and dry the combined extracts on Na 2 SO 4 , filter, concentrate, and punfy by column chromatography on silica gel (eluent 50% EtOAc in hexane to 10% MeOH in EtOAc) to obtain the title compound as a yellow solid B 4-Chloro-2-methyl-9-(2,4.6-tπmethylphenyl)pynmιdmor4,5-blmdolιzιne Heat at 100°C for 2 h a solution of 2-methyl-9-(2,4,6-tπmefhylphenyl)pyπrnιdιno[4,5- b]ιndohzιn-4-ol (120 mg) in phosphorus oxychlonde (2 mL), cool to ambient temperature, and concentrate in vacuo Partition the residue into ice water and CH 2 C1 2 Extract the aqueous phase twice with CH 2 CI 2 and wash the combined organic extracts with a saturated NaHCO 3 solution Dry the solution over Na-SO 4 , filter, and concentrate in vacuo Punfy the dark residue by column chromatography on silica gel (eluent 10% to 20% EtOAc in hexane) to obtain the title compound as a greenish yellow foam : Η NMR (400MHz, CDC1 3 ) δ 1.99 (s, 6 H), 2.38 (s, 3 H), 2.79 (s, 3 H), 6.80 (m, 1 H), 7.00 (s, 2 H), 7.19 (m, 2 H), 9.27 (d, 1 H). C. (2-Aminoethyl)r2-methyl-9-(2,4,6-trimethylphenyl)pyrimidinor4,5-b1indolizin-4- yll amine Heat a solution of 4-chloro-2-methyl-9-(2,4,6-trimethylphenyl)pyrimidino[4,5-b]indolizine (0.3 g, 0.89 mmol), and ethylene diamine (0.6 mL, 8.93 mmol) in dry NMP (3mL) at 100 ° C for 14 h. Pour the cooled mixture onto water (30 mL) and extracte twice with EtOAc (30 mL). Wash the combined extracts with brine (30 mL), dry, and evaporate in vacuo. Purify by preparative TLC (20 % MeOH in CH 2 C1 2 with 0.5% ammonium hydroxide) to obtain the title compound as a yellow oil. D. [2-(Cvclopentylamino)ethylir2-methyl-9-(2,4,6-trimethylphenyl)pyrimidinor4,5- b]indolizin-4-yl " | amine Treat a solution of (2-aminoethyl)[2-methyl-9-(2,4,6-trimethylphenyl)pyrimidmo[4,5- b]indolizin-4-yl]amine (0.07 g, 0.19 mmol), cyclopentanone (0.02 mL, 0.19 mmol) and acetic acid (0.01 mL, 0.19 mmol) in dry dichloroethane (3 mL) with sodium triacetoxyborohydride (0.06g, 0.27 mmol) and stir at ambient temperature for 14 h. Dilute the resulting mixture with CH 2 C1 2 (20 mL) and wash with saturated aq NaCl (50 mL). Dry the organic portion over Na 2 SO , filter, and concentrate under reduced pressure. Purify by preparative TLC (10 % MeOH in CH 2 CI 2 with 0.5 % ammonium hydroxide) to obtain the title compound as a yellow solid. EXAMPLE 3 A. N-(2-Amino-ethyl)-2-(4-ethoxy-3-methoxy-phenyl)-acetamide. Dissolve 4-ethoxy-3-methoxy-phenyl acetic acid (26 g, 119 mol) in dichloroethane (300 mL, anhydrous) and cool to 0°C. Dropwise add oxalyl chloride (130 mL, 2.0 M in CH 2 C1 2 ) and DMF (2 mL), then allow to warm to ambient temperature for 14 h. Concentrate under reduced pressure to a tan oil. Dissolve in dichloroethane (200 mL) and cool to 0°C while stirring under N 2 . Dropwise, over 45 minutes, add a second solution of N-tBOC- ethylenediamine (20 g) and triethylamine (20 mL) in dichloroethane (100 mL). Partition between CH 2 C1 2 (500 mL) and 1.0 N HCl (200 mL), separate the layers, and wash the organic phase with 1.0 N HCl (200 mL). Wash the organic layer with saturated K 2 CO 3 (2 X 200 mL), then dry the CH 2 C1 2 layer over Na 2 S0 , filter, and evaporate to tan solid. Triturate with Et 2 0 (200 mL) and stir vigorously to fragment solid, then filter and wash copiously with Et 2 0 to obtain a white solid. Dissolve the white solid (3.0 g, 8.52 mmol) in a 1 : 1 mixture of trifluoracetic acid and CH 2 C1 2 (10 mL) and stir at ambient temperature 1 h. Concentrate under reduced pressure and partition between CH 2 C1 2 (25 mL) and 1.0 N NaOH (25 mL), then separate the layers, and extract the aqueous layer with CH 2 C1 2 (25 mL). Pool the organic layers, dry over Na 2 SO 4 , filter and concentrate in vacuo to a white solid. B . N-(4-Ethoxy-3 -methoxy-phenethvD-ethylenediamine Treat a solution of N-(2-amino-ethyl)-2-(4-ethoxy-3-methoxy-phenyl)acetamide (0.7 g, 2.77 mmol) in THF (10 mL) with AlH 3 .NMe 2 Et (55 mL, 27.74 mmol) and heat to reflux for 14 h. Cool the resulting mixture to ambient temperature, quench with Na CO 3 .10H 2 0 (0.5 g) and stir at ambient temperature for 15 min. Filter the solution through Celite and wash with several portions of CH 2 C1 2 . Concentrate the filtrate in vacuoo and purify by preparative TLC (10 % MeOH in CH 2 C1 2 ) to obtain the title compound as a white oil. C. (2-(r2-(4-Ethoxy-3-methoxyphenyl)ethyllaminolethyl)r2.5.6-trimethyl-7-(2,4,6- trimethylphenyl)pyrrolo 3,2-e]pyrimidin-4-yllamine H Heat a solution of 4-chloro-2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyπolo[2,3- d]pyrimidine (340 mg, 1.1 mmol) and N-(4-ethoxy-3-methoxy-phenethyl)-ethylenediamine in NMP (2 mL) for 14 h at 130°C. Pour into water (5 mL) and extract with EtOAc (2 X 10 mL). Dry the combined organic extracts over Na 2 S0 4 , filter, and concentrate under reduced pressure. Purify by preparative TLC, eluting with 10% MeOH in CH 2 C1 2 . Dissolve the residue in a minimum amount of MeOH then add HCl in EtOAc (2 mL) and triturate with Et 2 0 to obtain the title compound as a solid (HCl salt). EXAMPLE 4 A. 2-(4-Methoxyphenyl)-N-(2-( 7-(4-methoxy-2.6-dimethylphenyl)-2,5- dimethylpyrrolo 2,3-elpyrimidin-4-yllaminolethyl')acetamide Heat a solution of 4-chloro-7-(4-methoxy-2,6-dimethyl-phenyl)-2,5-dimethyl-5H- pyrrolo[3,2-d]pyrimidine (120 mg, 0.38 mmol) and N-(2-amino-ethyl)-2-(4-methoxy- phenyl)-acetamide (125 mg) in NMP (2 mL) for 14 h at 130°C. Pour into water (5 mL) and extract with EtOAc (2 X 10 mL). Dry the combined organic extracts over Na 2 SO , filter, and concentrate under reduced pressure to obtain the title compound which is used without further purification. B. (2- (r2-(4-Methoxyphenyl)ethyll amino 1 ethyl)[7-(4-methoxy-2,6-dimethylphenyl)-2,5- dimethylpyHθlo[2,3-e]pyrimidin-4-yllamine Dissolve ^-(4-methoxyphenyl)-N-(2-{[7-(4-methoxy-2,^dimethylphenyl)-2,5- dimethylpyrrolo[2,3-e] pyrimidin-4-yl]aminoethyl)acetamide in anhydrous THF (5 mL) and stir under N 2 . Add borane-dimethylsulfide complex (0.2 mL, 10.0 M in THF) and heat to reflux for 14 h. Quench by addition of N,N'-dimefhyl- 1 ,2-efhylenediamine (0.21 mL) in MeOH (5 mL) and stir for 1 h at ambient temperature. Concentrate under reduced pressure and purify the residue by preparative TLC, eluting with 10% MeOH in CH 2 C1 2 . Dissolve the residue in a minimum amount of MeOH then add HCl in EtOAc (2 mL) and triturate with Et 2 O to obtain the title compound as a solid (HCl salt). EXAMPLE 5 A. 4-Chloro-6-methyl-3-nitro-pyridin-2-ol Add 1-ethylpropylamine (9.00 g, 76.4 mmol) to a solution of 4-hydroxy-6-mefhyl-3- nitropyridone (10.0 g, 58.8 mmol) in anhydrous MeOH (20 mL). Stir the mixture until clear, then concentrated in vacuo. Add the residue portionwise to phosphorus oxychloride (70 mL), Stir at ambient temperature for 10 h, and pour onto ice-water. After stirring for 20 min, filter the precipitate, and dry over Na 2 S0 to obtain the title compound as a yellow solid. B. 4-Benzylamino-6-methyl-3-nitro-pyridin-2-ol Stir a solution of 4-chloro-6-methyl-3-nitro-pyridin-2-ol (10.0 g, 53.0 mmol) and benzyl amine (17.3 g, 159 mmol) in EtOH (30 mL) at ambient temperature for 12 h, then concentrate in vacuo. Pour the resulting residue into water, acidify to pH 3 with 1N"HC1 and filter. Wash the precipitate several times with water to obtain the title compound as a yellow solid. C. 4-Benzylamino-6-methyl-3-nitro-2-chloro-pyridine Heat a solution of 4-benzylamino-6- methyl-3-nitro-pyridin-2-ol (13.70 g, 52.8 mmol) and tetramethylammonium chloride (6.0 g, 52.8 mmol) to reflux in phosphorus oxychloride (15 mL) for 5 h. After cooling, remove the excess phosphorus oxychloride in vacuo. Triturate the residue in ice-water (400 mL) to obtain the title compound as a brown solid. D. 6-Methyl-3-nitro-4-rbenzylaminol(2-pyridyl)}(2,4,6-trimethylphenyl)amine Add p-toluene sulfonic acid (11.0 g, 56.3 mmol) to a solution of 4-benzylamino-6-methyl- 3-nitro-2-chloro-pyridine (13.0 g, 46.8 mmol) and 2,4,6-trimethylaniline (6.58 g, 46.8 mmol) in 350 mL of toluene. Heat the resulting mixture for 14 h under reflux using a Dean-Stark trap. After cooling to ambient temperature, dilute the solution with EtOAc (200 mL) and wash successively with saturated aq NaHCO and saturated aq NaCl . Separate the organic layer, dry over Na 2 S0 , filter, and concentrate in vacuo. Purify by flash column chromatography (2% methanol in CH 2 C1 2 ) to obtain obtain the title compound as a dark yellow solid. E. 3-Amino-6-methyl-4-[benzylaminol(2-pyridyl)(2.4.6-trimethylphenyl)amine Add iron powder (7.0 g) to a solution of 6-methyl-3-nitro-4-[benzylamino](2-pyridyl)(2,4,6- trimethylphenyl)amine (8.75 g, 23.2 mmol) in acetic acid (14 mL) and MeOH (70 mL). Heat the resulting mixture at 70°C for 1 h, cool to ambient temperature, and filter through a pad of celite. Evaporate the filtrate to dryness under reduced pressure. Treat he residue with IN aq NaOH and extract with EtOAc . Wash the EtOAc extract with water and saturated aq NaCl . Separate the organic layer, dry over Na 2 SO 4 , filter, and concentrate to obtain the title compound as a brown solid which is used without further purification. F. r5-methyl-3-(2.4.6-trimethylphenyl)imidazolor5.4-b1pyridin-7-yl1benzylamine Treat a solution of 3-amino-6-methyl-4-[benzylamino](2-pyridyl)(2,4,6- trimethylphenyl)amine (0.80 g, 2.31 mmol) and triethyl orthoformate (8.0 mL, 48.5 mmol) in dimethylacetamide (9 mL) with 12 M HCl (0.4 mL). Stir the mixture at ambient temperature for 14 h, Tύte with EtOAc (50 mL), and wash with aq faHC0 3 (50 mL) and saturated aq NaCl (50 mL). Dry the organic layer over Na 2 SO , filter, and concentrate. Purify by preparative TLC (10 % methanol in CH 2 C1 2 with 0.1% ammonium hydroxide) to obtain the title compound as a solid. G. 5-methyl-3-(2.4.6-trimethylphenyl)imidazolo 5.4-blpyridin-7-ylamine Add palladium hydroxide (0.05 g) to a solution of [2,5-dimethyl-3-(2,4,6- trimethylphenyl)imidazolo[5,4-b]pyridin-7-yl]benzylamine (0.15g , 0.42 mmol) in acetic acid (10 mL). Hydrogenate the mixture at a pressure of 50 psi for 20 hr. Filter the reaction mixture through celite, evaporate to dryness under reduced pressure, dilute with EtOAc and successively wash with aq NaHC0 3 and aq NaCl. Dry the organic layer over Na 2 SO 4 , filter, and concentrate. Purify by flash column chromatography ( 3% MeOH in CH 2 CI2) to obtain the title compound as a brown solid. H. N-r5-methyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-blpyridin-7-yl1-2-chloroacetamide Treat a solution of 5-methyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-b]pyridin-7-ylamine (0.05 g, 1.9 mmol), and N,N-diisopropylethylamine, (0.04 mL, 0.21 mmol) in 1, 2- dichloroefhane (5 mL) with chloroacetyl chloride (0.017 mL, 0.21 mmol). Heat the solution to reflux for 3 h, cool to ambient temperature, and pour into an aqueous potassium carbonate solution. Extract the resulting mixture with CH 2 Cl 2 and wash with " saturated aq NaCl. Separate the organic layer, dry over Na 2 SO 4 , filter, and concentrate. Purify by preparative TLC (5 % MeOH in CH 2 C1 2 ) to obtain the title compound as a yellow solid. I. (2-Chloroethyl) 5-methyl-3-(2,4,6-trimethylphenyl)imidazolor5,4-blpyridin-7-yl1-amine Treat a solution of N-[5-methyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-b]pyridin-7-yl]-2- chloroacetamide (0.04 g, 0.10 mmol) in THF (5mL) with borane-methyl sulfide complex (0.03 mL, 0.30 mmol). Heat the mixture to reflux for 8 h and quench at ambient temperature with a large excess of MeOH, followed by 6 N HCl (2 mL). Re-heat the mixture to reflux for 1 h, then concentrate under reduced pressure to obtain the title compound as a yellow solid. J. (2-{ 2-(4-Ethoxy-3-methoxyphenyl)ethyllaminolethyl)[5-methyl-3-(2.4,6- trimethylphenyl)imidazolo 5,4-b]pyridin-7-yllamine Heat a solution of (2-chloroethyl)[5-methyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4- b]pyridin-7-yl]-amine (0.030 g, 0.09 mmol) and 4-ethoxy-3-methoxy phenethylamine (0.10 g, 0.55 mmol) in dry NMP (2 mL) at 1 10°C for 16 h. Pour the cooled mixture onto water (20 mL) and extract twice with EtOAc (20 mL). Wash the combined extracts with brine (30 mL), dry, and evaporate in vacuo. Purify by flash column chromatography (10% MeOH in CH 2 C1 2 with 0.1% ammonium hydroxide) to obtain the title compound as a solid. EXAMPLE 6 A. [2,5-dimethyl-3-(2,4,6-trimethylphenyl)imidazolo[5.4-b1pyridin-7-yllbenzylamine Heat a solution of 3-amino-6-methyl-4-[benzylamino](2-pyridyl)(2,4,6- trimethylphenyl)amine (2.50 g, 7.21 mmol), triethyl orthoacetate (2.6 mL, 14.4 mmol) and camphorsulfonic acid (250 mg) in toluene (50 mL) to reflux for 14 h. After cooling to ambient temperature, concentrate the mixture in vacuo, dilute with water (100 mL), and extract with EtOAc. Wash the EtOAc extract successively with water and saturated aq NaCl, dry over Na 2 SO 4 , filter, and concentrate. Purify by flash column chromatography (5% methanol in CH 2 C1 2 ) to obtain the title compound as a white solid. B. 2,5-Dimethyl-3-(2,4,6-trimethylphenyl)imidazolo[5.4-blpyridine-7-ylamine Add palladium hydroxide (2.0 g) to a solution of | 5-dimefhyl-3-(2,4,6- trimethylphenyl)imidazolo[5,4-b]pyridin-7-yl]benzylamine (1.50 g , 4.05 mmol) in acetic acid (10 mL). Hydrogenate the mixture at a pressure of 40 psi for 20 hr. Filter the reaction mixture through celite, evaporate to dryness under reduced pressure, dilute with EtOAc and successively wash with aq. NaHCO 3 and aq NaCl. Dry the organic layer over Na SO , filter, and concentrate. Purify by flash column chromatography ( 3% MeoH in CH 2 C1 2 ) to obtain the title compound as a white solid. C. N-[2,5-Dimethyl-3-(2,4.6-trimethylphenyl)ιmidazolo[5,4-b]pyridin-7-yll-2- chloro acetamide Treat a solution of 2,5-dimethyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-b]pyridine-7- ylamine (0.8 g, 2.85 mmol), and N,N-diisopropylethylamine, (0.54 mL, 3.13 mmol) in 1, 2- dichloro ethane (10 mL) with chloroacetyl chloride (0.25 mL, 3.13mmol). Heat the solution to reflux for 5 h, cool to ambient temperature, and pour into an aqueous potassium carbonate solution. Extract the resulting mixture with CH 2 C1 2 and wash with saturated aq NaCl. Separate the organic layer, dry over Na 2 S0 4 , filter and concentrate. Purify by preparative TLC (5 % MeOH in CH 2 C1 2 ) to obtain the title compound as a brown solid. P. [2,5-Dimethyl-3-(2.4,6-trimethylphenyl)imidazolor5,4-blpyridin-7-yll(2- chloro ethyl )amine Treat a solution of N-[2,5-dimethyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-b]pyridin-7-yl]- 2-chloroacetamide (0.91 g, 2.55 mmol) in THF (5mL) with borane-methyl sulfide complex (0.8 mL, 7.65 mmol). Heat the mixture to reflux for 18 h and quench at ambient temperature with a large excess of MeOH, followed by 6N HCl (5 mL). Re-heat the mixture to reflux for 1 h, then concentrate under reduced pressure to obtain the title compound as a white crystalline solid. E. 2,5-Dimethyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-blpyridin-7-ylir2- (cvclohexylamino)efhyllamine Heat a solution of [2,5-dimethyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-b]pyridin-7-yl](2- chloroefhyl)amine ( 0.04 g, 0.12 mmol), and cyclohexyl amine (0.13 mL g, 1.16 mmol) in dry NMP (2 mL) at 80 °C for 20 h. Pour the cooled mixture onto water (20 mL) and extract twice with ethyl acetate (20 mL). Wash the combined extracts with brine (20 mL), dry, and evaporate in vacuo. Purify by flash column chromatography (10% methanol in CH 2 C1 2 with 0.1% ammonium hydroxide) to obtain the title compound as a white solid. EXAMPLE 7 A. 3-(2.4-dichlorophenyl)-2,5-dimethylimidazolor5.4-blpyridin-7-ylamine Stir a solution of [3-(2,4-dichlorophenyl)-2,5-dimethylimidazolo[5,4-b]pyridin-7-yl](4- methoxybenzyl)amine (4.23 g, 10 mmol), anisole (3.2 mL, 29.6 mmol), trifluoroacetic acid (80 mL), and concentrated sulfuric acid (2 mL) at ambient temperature for 14 h. Add the resulting mixture dropwise to ice-water and dilute with NaHC0 3 . Filter the resulting precipitate and wash thoroughly with water to obtain the title compound as a brown solid. B. N- 3-(2,4-dichlorophenyl)-2,5-dimethylimidazolo[5,4-b]pyridin-7-yll-2-chloroacetamide Treat a solution of 3-(2,4 -dichlorophenyl)-2,5-dimethylimidazolo[5,4-b]pyridin-7-ylamine (0.2 g, 0.65 mmol), and N,N-diisopropylethylamine, (0.12 mL, 0.72 mmol) in 1, 2- dichloroethane (10 mL) with chloroacetyl chloride (0.06 mL, 30.72 mmol). Heat the solution to reflux for 2 h, cool to ambient temperature, and pour into an aqueous potassium carbonate solution. Extract the resulting mixture with CH 2 C1 2 and wash with saturated aq NaCl. Separate the organic layer, dry over Na 2 S0 4 , filter, and concentrate. Purify by preparative TLC (5 % methanol in CH 2 CI 2 ) to obtain the title compound as a yellow solid. C. 3-(2.4-dichlorophenvιV2,5-dimethylimidazolor5.4-blpyridin-7-ylir2^chloroethyl)amine Treat a solution of N-[3-(2,4 = dichlorophenyl)-2,5-dimethylimidazolo[5,4-b]pyridin-7-yl]-2- chloroacetamide (1.0 g, 2.6 mmol) in THF (5mL) with borane-methyl sulfide complex (0.8 mL, 7.8mmol). Heat the mixture to reflux for 3 h and quench at ambient temperature with a large excess of MeOH followed by 5 N HCl (2 mL). Re-heat the mixture to reflux for 1 h, then concentrate under reduced pressure. Purify by flash column chromatography (50% EtOAc-hexane) to obtain the title compound as a beige solid. P. r3-(2.4-dichlorophenyl -2.5-dimethylimidazolor5.4-b1pyridin-7-ylir2- (cvclopentylamino)ethyl] amine Heat a solution of [3-(2,4-dichlorophenyl)-2,5-dimethylimidazolo[5,4-b]pyridin-7-yl](2- chloroethyl)amine ( 0.08 g, 0.22 mmol), and cyclopentyl amine (0.2 mL g, 0.22 mmol) in dry NMP (3 mL) at 80 °C for 20 h. Pour the cooled mixture onto water (30 mL) and extract twice with EtOAc (50 mL). Wash the combined extracts with brine (50 mL), dry, and evaporate in vacuo. Purify by preparative TLC (10% MeOH in CH 2 Cl 2 ) to obtain the title compound as a yellow oil. EXAMPLE 8 A. Ethyl 4-(2.6-dichlorophenyl)-2.4-dioxobutanoate To a solution of 2',6'-dichloroacetophenone (12.5g, 66 mmol) and diethyl oxalate (14.6g, lOOmmol) in 450 mL of anhydrous toluene, cautiously add sodium hydride (60% dispersion in mineral oil, 2.8g, 70 mmol). Cautiously heat the reaction mixture to reflux under N 2 for 1 h, cool to ambient temperature and pour onto ice-cold 1M HCl. Separate the layers and extract the aqueous phase with EtOAc (2 x 200 mL). Wash the combined organic extracts with brine, dry over MgSO 4 and evaporate to obtain the title compound which is used in the next step without further purification. B. Ethyl 4-(2.6-dichlorophenyl)-3-(hvdroxyimino)-2,4-dioxobutanoate Slowly bubble N 2 O 3 gas (generated by the dropwise addition of concentrated HCl into an aqueous solution of sodium nitrite) into a stirred solution of ethyl 4-(2,6-dichlorophenyl)-2,4- dioxobutanoate (14.4 g, 50 mmol) in EtOH (300 mL) until the reaction is complete (as determined by TLC). Remove the EtOH by evaporation under reduced pressure and partition the residue between EtOAc and water. Dry the organic extract over MgSO and evaporate in vacuo to obtain the title compound which is used in the next step without further purification. C. Ethyl 4-amino-5-(2,6-dιchlorophenyl)-l-methylpyrazole-3-carboxylate To a solution of ethyl 4-(2,6-dichlorophenyl)-3-(hydroxyimino)-2,4-dioxobutanoate (14 g, 44 mmol) in MeOH (400 mL) at 0°C, add dropwise concentrated HCl (10 mL) followed by methyl hydrazine (2.02g, 44 mmol). Stir the reaction mixture at ambient temperature for 8 h and concentrate in vacuo. Partition the residue between EtOAc (400 mL) and saturated aqueous NaHCO 3 (150 mL) and separate the layers. Add water (200 mL) to the organic layer, followed by sodium hydrosulfite (150 g) and stir the resulting mixture vigorously for 4 h. Separate the organic phase, wash with water (200 mL), brine (200 mL), dry over MgSO and evaporate to obtain the title compound. D. 3-(2.6'-Dichlorophenyl)-2,5-dimethyl-6-hydropyrazolo[4,3-d1pyrimidin-7-one Saturate a solution of ethyl 4-amino-5-(2,6-dichlorophenyl)-l-methylpyrazole-3-carboxylate (6 g, 20 mmol) in acetonitrile (150 mL) with HCl gas, stir at ambient temperature for 14 h and then concentrate. Partition the residue partition between EtOAc (150 mL) and aqueous NaHCO 3 (150 mL) and separate the layers. Wash the organic layer with brine (100 mL), dry over MgSO 4 and concentrate. Triturate the residue with Et 2 0, and collect the yellow solid by filtration to obtain the title compound. E. 3-(2,6-Dichlorophenyl)-7-chloro-2,5-dimethylpyrazolo 4,3-d1pyrimidine Heat a solution of 3-(2,6-dichlorophenyl)-2,5-dimethyl-6-hydropyrazolo[4,3-d]pyrimidin-7- one (3.09 g, 10 mmol), POCl 3 (35 mL) and Λ V-dimethylaniline (1.44 g, 12 mmol) at 90°C for 8 h. Remove the volatiles by evaporation, re-dissolve the residue in CH 2 CI 2 (100 mL) and wash with aqueous NaHCO 3 (2 x 50 mL). Dry the organic layer over MgSO 4 and concentrate under reduced pressure. Purify the residue by flash column chromatography (silica, eluent 50% Et 2 0 in hexane) to obtain the title compound. F. (2-Aminoethyl)r3-(2.6-dichlorophenyl)-2,5-dimethylpyrazolor3.4-elpyrimidin-7-yl1amine To a stiπed solution of 3-(2,6-dichlorophenyl)-7-chloro-2,5-dimethylpyrazolo[4,3- d]pyrimidine (652 mg, 2.0 mmol) in acetonitrile (50 mL) at 50°C, add ethylene diamine (2.4 g, 40 mmol) in one portion. Maintain the reaction at 50°C for 2 h, cool to ambient temperature and remove the volatiles by evaporation. Partition the residue between CH 2 C1 2 (50 mL) and IN NaOH (50 mL) and extract the aqueous layer with CH 2 C1 2 (2 x 30 mL). Wash the combined organic extracts with water (30 mL), brine (30 mL), dry over MgSO 4 and evaporate to obtain the title compound. G. r3-(2,6-Dichlorophenyl)-2,5-dimethylpyrazolo 3,4-elpyrimidin-7-ylir2- cyclopentylamino)ethyl]amine To (2-aminoethyl)[3-(2,6-dichlorophenyl)-2,5-dimethylpyrazolo[3,4-eJpyrimidin-7-yl]amine (140 mg, 0.4 mmol) in dichloroethane (5 mL), add cyclopentanone (34 mg, 0.4 mmol), sodium triacetoxyborohydride (106 mg, 0.5 mmol) and glacial acetic acid (24 mg, 0.4 mmol). Stir the reaction mixture at ambient temperature for 2 h and pour into IN NaOH (10 mL). Separate the layers and extract the aqueous phase with CH 2 C1 2 (2 x 10 mL). Wash the combined organic extracts with water (10 mL), brine (10 mL), dry over MgSO and evaporate in vacuo. Purify by preparative TLC (eluent 10% MeOH in chloroform) to obtain the title compound. EXAMPLE 9 A. /V-(2-{[3-(2.6-Dichlorophenyl)-2,5-dimethylpyrazolo[3,4-e1pyrimidin-7-yl1aminol-2-(4- ethox y-3 -mefhoxyphenv 1) acetamide To a stirred solution of (2-aminoethyl)[3-(2,6-dichlorophenyl)-2,5-dimethylpyrazolo[3,4- e]pyrimidin-7-yl]amine (175 mg, 0.5 mmol) in NN-dimethylacetamide (5 mL), add 4- methylmorpholine (101 mg, 1.0 mmol), 2-(4-ethoxy-3-methoxyphenyl)acetic acid (115 mg, 0.55 mmol) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (331 mg, 0.75 mmol). Stir the reaction mixture at ambient temperature for 14 h and dilute with EtOAc (15 mL). Wash the organic extracts successively with water (10 mL), brine (10 mL), saturated NH 4 C1 (10 mL), 2N NaOH (10 mL), brine (10 mL), dry over MgS0 4 and evaporate under reduced pressure to obtain the title compound. B. [3-(2,6-dichlorophenyl)-2,5-dimethylpyrazolo[3,4-e1pyrimidin-7-yll(2-{r2-(4-ethoxy-3- methoxyphenvDethyllaminolethvDamine To a stirred solution of N-(2-{[3-(2,6-dichlorophenyl)-2,5-dimethylpyrazolo[3,4-e]pyrimidin- 7-yl]amino}-2-(4-ethoxy-3-methoxyphenyl)acetamide (175 mg, 0.5 mmol) in THF (5 mL), add borane-dimethylsulfide complex (IM in THF, 0.25 mL, 2.5 mmol). Heat the reaction mixture to reflux for 14 h, cool to ambient temperature and quench by careful addition of MeOH (3 mL). Remove the volatile by evaporation and re-dissolve the residue in MeOH (5 mL). Add HCl in Et 2 0 (IM, 2 mL) and heat the solution to reflux for 1 h. Remove the volatiles by evaporation under reduced pressure, dissolve the residue in CH 2 C1 2 (20 mL) and wash with saturated NaHCO 3 (20 mL) and brine (10 mL). Dry the organic layer over MgSO 4 and concentrate in vacuo. Purify of the residue by preparative TLC (eluent 20% MeOH in chloroform) to obtain the title compound. EXAMPLE 10 A. [5-Methyl-3-(2,4,6-trimethylphenyl)( 2,3-triazolino[5,4-blpyridin-7-yl)lbenzylamine Treat a solution of 3-amino-6-methyl-4-[benzylamino](2-pyridyl)(2,4,6- trimethylphenyl)amine (1.70 g, 4.91 mmol) in THF (25 mL) with tetrafluoroboric acid (0.86 g, 9.81 mmol) at 0°C. Add dropwise isoamyl nitrite (0.86 g, 7.36 mmol) to the reaction mixture, stir at ambient temperature for 30 min, dilute with EtOAc (30 mL), wash with aq NaHC0 (40 mL), then with saturated aq NaCl (30 mL). Dry the organic layer over Na 2 SO , filter, and concentrate in vacuo. Purify by flash column chromatography (50% ethyl acetate- hexane) to obtain the title compound as a solid. B. 5-Methyl-3-(2,4,6-trimethylphenyl)-l,2,3-triazolino 5,4-blpyridine-7-ylamine Add palladium hydroxide (0.5 g) to a solution of [5-methyl-3-(2,4,6-trimefhylphenyl)(l,2,3- triazolino[5,4-b]pyridin-7-yl)]benzylamine (0.75g , 2.10 mmol) in acetic acid (10 mL). Hydrogenate the mixture at a pressure of 50 psi for 17 h. Filter the mixture through celite, evaporate to dryness under reduced pressure, dilute with EtOAc and successively wash with aq NaHCO 3 and aq NaCl. Dry the organic layer over Na 2 S0 4 , filter, and concentrate in vacuo. Purify by flash column chromatography ( 3% MeOH in CH 2 C1 2 ) to obtain the title compound as a solid. C. 2-Chloro-N-r5-methyl-3-(2.4.6-trimethylphenyl)(1.2.3-triazolinor5,4-blpyridin-7- vDlacetamide Treat a solution of 5-methyl-3-(2,4,6-trimethylphenyl)-l ,2,3-triazolino[5,4-b]pyridine-7- ylamine (1.0 g, 3.74 mmol), and N.N-diisopropylethylamine, (0.7 mL, 4.11 mmol) in 1 , 2- dichloroethane (10 mL) with chloroacetyl chloride (0.33 mL, 4.11 mmol). Heat the solution to reflux for 3 h, cool to ambient temperature, and pour into an aqueous potassium carbonate solution. Extract the resulting mixture with CH 2 G 2 and wash with saturated aq NaCl. Separate the organic layer, dry over Na 2 SO 4 , filter and concentrate. Purify by flash column chromatography (30% ethyl acetate-hex ane)to obtain the title compound as a white crystalline solid. P. (2-Chloroethyl r5-methyl-3-(2,4,6-trimethylphenyl)(L2,3-triazolinor5,4-blpyπdin-7- vDlamine Treat a solution of 2-chloro-N-[5-methyl-3-(2,4,6-trimethylphenyl)(l,2,3-triazolino[5,4- b]pyridin-7-yl)]acetamide (0.80 g, 2.33 mmol) in THF (7 mL) with borane-methyl sulfide complex (0.7 mL, 7.0 mmol). Heat the mixture to reflux for 8 h and quench at ambient temperature with a large excess of methanol. Re-heat the mixture to reflux for 1 h, then concentrate under reduced pressure to obtain the title compound as a yellow solid. E. (2-(r2-(4-Ethoxy-3-methoxyphenyl)ethyllaminolethyl)r5-methyl-3-(2.4.6- trimethylphenyl)( 2,3-triazolino[5,4-blpyridin-7-yl)lamine Heat a solution of (2-chloroethyl)[5-methyl-3-(2,4,6-trimethylphenyϊ)(l,2,3-triazolino[5,4- b]pyridin-7-yl)]amine (0.150 g, 0.45 mmol) and 4-ethoxy-3-methoxy phenethylamine (0.53 g, 2.73 mmol) in dry NMP (3 mL) at 80°C for 14 h. Pour the cooled mixture onto water (50 mL) and extract twice with EtOAc (30 mL). Wash the combined extracts with brine (30 mL), dry, and evaporate in vacuo. Purify by flash column chromatography (10% MeOH in CH 2 C1 2 -0.1% ammonium hydroxide) to obtain the title compound as a solid. EXAMPLE 11 A. r2-(Cyclopentylamino)ethyll[5-methyl-3-(2,4,6-trimethylphenyl)(1.2,3-triazolinor5,4- blpyridin-7-yl)l amine Heat a solution of (2-chloroethyl)[5-methyl-3-(2,4,6-trimethylphenyl)(l,2,3-triazolino[5,4- b]pyridin-7-yl)] amine (0.06 g, 0.18 mmol), and cyclopentyl amine (0.53 g, 1.82 mmol) in dry NMP (3 mL) at 80 °C for 14 h. Pour the cooled mixture onto water (30 mL) and extract twice with EtOAc (20 mL). Wash the combined extracts with brine (20 mL), dry, and evaporate in vacuo. Purify by flash column chromatography (10% methanol- CH 2 C1 2 -0.1% ammonium hydroxide) to obtain the title compound as a solid. EXAMPLE 12 A. 4,6-Dichloro-2-methyl-5-amino-pyrimidine Add iron powder (6.0 g) to a solution of 4,6 dichloro-2-methyl-5-nitro-pyrimidine (6.50 g, 31 mmol) in acetic acid (11 mL) and MeOH (50 mL) . Heat the resulting mixture at 65 °C for 1 h. After cooling, to ambient temperature, filter the mixture through a pad of celite, and evaporate the filtrate to dryness under reduced pressure. Treat the residue with IN aq NaOH, and extract with EtOAc . Wash the EtOAc extract with water and saturated aq NaCl, dry over Na 2 SO 4 , filter, and concentrate in vacuo to obtain the title compound as a solid. B. (5-Amino-6-chloro-2-methylpyrimidin-4-yl)r(2-bromo-4-isopropyl)phenyllamine Heat a solution of 4,6-dichloro-2-methyl-5-amino-pyrimidine (2.0 g, 11.2 mmol) and 2- bromo-4-isopropylamine (2.4 g, 11.2 mmol) at 140 °C for 1 h. After cooling to ambient temperature, dilute the mixture with EtOAc (25 mL), and wash with IN NaOH (50 mL) and saturated aq NaCl (20 mL). Dry the organic layer over Na 2 SO 4 , filter, and concentrate under reduced pressure to obtain the title compound as a dark oil which is used without further purification. C. 9-r(2-Bromo-4-isoρropyl)-phenyl1-6-chloro-2-methyl-7-hydropurin-8-one Treat a solution of (5-amino-6-chloro-2-methylpyrimidin-4-yl)[(2-bromo-4- isopropyl)phenyl]amine (1.0 g, 2.88 mmol) and triethyl amine (0.27 mL, 1.97 mmol) in THF (10 mL) with triphosgene (0.3 g, 0.98 mmol) and stir at ambient temperature for 14 h. Quench the reaction mixture with water and dilute with EtOAc (20 mL). Separate the organic layer, wash with brine (20 mL), dry over Na 2 SO 4 , filter, and concentrate under reduced pressure. Purify by flash column chromatography (50% EtOAc- hexane) to obtain the title compound as a dark brown solid. D. 6-[(2-Aminoethyl)aminol-9-[(2-bromo-4-isopropyl)phenyll-2-methyl-7-hydropurin-8- one Heat a solution of 9-[(2-bromo-4-isopropyl)-phenyl]-6-chloro-2-methyl-7-hydropurin-8-one (0.34 g, 0.89 mmol), and ethylenediamine (0.32 g, 5.37 mmol) in dry NMP (2 mL) at 85° C for 14 h. Pour the cooled mixture onto water (50 mL) and extract twice with EtOAc (30 mL). Wash the combined extracts with brine (30 L), dry, and evaporate in vacuo to obtain the title compound which is used without further purification. E. 9-r(2-Bromo-4-isopropyl)phenyl]-6-{[2-(cvclohexylamino)ethyllaminol-2-methyl-7- hydropurin-8-one Treat a solution of 6-[(2-aminoefhyl)amino]-9-[(2-bromo-4-isopropyl)phenyl]-2-methyl-7- hydropurin-8-one (0.100 g, 0.248 mmol), cyclohexanone (0.03 mL, 0.248 mmol) and acetic acid (0.01 mL, 0.248 mmol) in dry dichloroethane (3 mL) with sodium triacetoxyborohydride (0.07g, 0.347 mmol) and stir at ambient temperature for 10 h. Dilute the resulting mixture with CH 2 C1 2 (20 mL) and wash with saturated aq NaCl (50 mL). Dry the organic phase over Na 2 SO 4 , filter, and concentrate under reduced pressure. Purify by preparative TLC (10 % methanol in CH 2 C1 2 with 0.5 % ammonium hydroxide) to obtain the title compound as a yellow solid. EXAMPLE 13 A. (2-Aminoethyl)[2-methyl-8-(2,4,6-trimethylphenyl)(4-quinolyl)lamine In a sealed tube, heat 4-bromo-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline (100 mg, 0.29 mmol) at 140°C in a mixture of ethylene glycol (1 mL) and ethylene diamine (0.3 mL). After 4 h, cool the reaction mixture and partition between saturated aqueous NaHCO and chloroform. Dry the combined organic extracts on Na 2 S0 4 and concentrate under reduced pressure to obtain the title compound as a yellow glass: +APcI MS (M+l) + 320; Η NMR (methanol-d 4 ) δ: 7.78 (dd, IH), 7.39 (t, IH), 7.34 (dd, IH), 6.95 (s, 2H), 6.31 (s, IH), 3.34 (t, 2H), 3.1 1 (t, 2H), 2.43 (s, 3H), 2.34 (s, 3H), 1.89 (s, 6H). B. r2-Methyl-8-(2.4.6-trimethylphenyl)(4-quinolyl)ir2-(2-1.2.3.4- tetrahydronaphthylamino)ethyl]amine hydrochloride To a stiπed solution of (2-aminoethyl)[2-methyl-8-(2,4,6-trimethylphenyl)(4-quinolyl)]amine (21 mg, 0.066 mmol) and l,2,3,4-tetrahydro-2-naphthalenone (42 mg, 0.29 mmol) in MeOH (1 mL)/acetic acid (0.01 mL), add sodium cyanoborohydride (4 mg, 0.3 mmol). After stiπing 4 h, concentrate the reaction mixture under reduced pressure and partition between saturated aqueous NaHCO 3 and chloroform. Dry the combined organic extracts on Na 2 SO 4 , concentrate under reduced pressure, and purify by column chromatography on silica gel (eluent: 32:1 EtOAc/trie hylamine) to obtain the title compound as a colorless glass. Treat a methanolic solution of the product with concentrated aqueous hydrochloric acid to generate the hydrochloride salt. Concentrate the solution under reduced pressure and triturate the residue in Et 2 O to obtain the title compound as a colorless solid: +APcI MS (M+l) + 450; 1H NMR (metnanol-d- δ: 8.52 (dd, IH), 7.78 (t, IH), 7.62 (dd, IH), 7.15-7.00 (m, 7H), 4.06 (t, 2H), 2.66 (s, 3H), 2.38 (s, 3H), 1.87 (s, 6H). EXAMPLE 14 A. 2-(3,4-Dimethoxyphenyl)-N-(2-( 3.6-dimethyl-2-(2,4,6-trimethylphenoxy)(4- pyridyDl amino } ethvDacetamide Stir a solution- of [3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-4-pyridyl][2- (methylamino)ethyl] amine (68 mg, 0.23 mmol), 3,4-dimethoxyphenylacetic acid (59 mg, 0.3 mmol), EDC (59 mg, 0.3 mmol) and HOBT (41 mg, 0.3 mmol) in DMF (1.0 mL) for 12 h. Dilute the reaction mixture with EtOAc (10 mL) and wash with saturated aq NaHCO 3 (2 x 10 mL) and saturated aq brine (2 x 10 mL), dry and concentrate in vacuo to obtain the title compound as an oily residue. M+l : 478. B. (2-(r2-(3,4-Dimethoxyphenyl)ethyllaminolethvnr3.6-dimethyl-2-(2.4.6- trimethylphenoxy) (4-pyridyl)lamine Add BH 3 in THF (1 M solution, 0.3 mmol, 0.3 mL) to a solution of the crude 2-(3,4- dimethoxyphenyl)-N-(2-{[3,6-dimethyl-2-(2,4,6-trimethylphenoxy)(4-pyridyl)]amino}ethyl) acetamide in THF (2.0 mL) at ambient temperature. Heat the reaction mixture under reflux for 15 h, dilute with a solution of 10% aq HCl/MeOH (1 :1, 2 mL) and heat again under reflux (1 h). Dilute the reaction mixture with CHC1 3 (10 mL), wash with saturated aq NaHCO 3 (1 x 5 mL), dry and concentrate in vacuo. Chromatograph the crude residue on SiO 2 -gel using a gradient of 100% EtOAc to 10% Et 2 NH/EtOAc to obtain the title compound as a colorless oil. Immediately dissolve the product in Et 2 O (1 mL), treat with excess 4 M HCl/dioxane and concentrate in vacuo to obtain the hydrochloride salt of the title compound as a colorless solid. Η NMR (dVMeOH, Unity 400): d 6.99 - 6.77 (6H, m), 3.81 (3H, s), 3.78 (3H, s), 3.62 (2H, m), 2.98 (2 H, t), 2.39 (3H, s), 2.29 (3H, s), 2.16 (3H, s), 2.07 (6H, s). M+l : 464. EXAMPLE 15 A. (2-Aminoethyl {2-methyl-6- (2.4.6-trimethylphenyl)aminolpyrimidin-4-vU amine Heat a solution of 6-chloro-2 methyl-pyrimidin-4-yl)-(2,4,6-trimethyl-phenyl)-amine (0.50 g, 1.91 mmol), and ethylenediamine (1.28 mL, 19.10 mmol) in dry NMP (5 mL) at 100 °C for 14 h. Pour the cooled mixture onto water (50 mL) and extract twice with EtOAc (30 mL). Wash the combined extracts with brine (30 mL), dry, and evaporate in vacuo. Purify by preparative TLC (10 % methanol- CH 2 C1 2 - 0.5 % ammonium hydroxide) to obtain the title compound. B. 2-(4-Ethoxy-3-methoxy-phenyl)-N-(2-r2-methyl-6-(2,4,6-trimethyl-phenylamino)- pyrimidin-4-ylamino]ethyl| -acetamide To a solution of (2-aminoethyl){2-methyl-6-[(2,4,6-trimethylphenyl)amino]pyrimidin-4- yl}amine (0.36g, 1.26 mmol), 4-ethoxy-3-methoxyphenethylamine (0.26g, 1.26 mmol)) and N,N diisopropylethyl amine (0.24 ml, 1.38 mmol in CH 2 C1 2 (5 mL), add benzotriazol-1- yloxytris-(dιmethylamino)phosphonium hexafluorophosphate (0.61g, 1.38 mmol) and stir at ambient temperature for 14 h. Dilute the resulting mixture with CH 2 C1 2 (20 mL), and wash with water (20 mL) and saturated aq NaCl (20 mL). Dry the organic layer over Na 2 SO 4 , filter and concentrate in vacuo. Purify by preparative TLC (7 % methanol- CH 2 C1 2 ) to obtain the title compound. C. (2- (r2-(4-Ethoxy-3-nrethoxyphenvnethyllaminolethyl){2-methyl-6 (2.4.6- trimethylphenyl)amino]pyrimidin-4-vU amine Heat a solution of 2-(4-ethoxy-3-methoxy-phenyl)-N- {2-[2-methyl-6-(2,4,6-trimethyl- phenylamino)-pyrimidin-4-ylamino]ethyl}-acetamide ( 0.324 g, 0.68 mmol) in THF (10 mL) with AlH 3 .NMe 2 Et (14 mL, 6.78 mmol) to reflux for 14 h. Cool the resulting mixture to ambient temperature, quench with Na 2 CO 3 .10H 2 0 (1.0 g) and stir at ambient temperature for 15 min. Filter the solution through Celite and wash with several portions of CH 2 C1 2 . Concentrate the filtrate in vacuo to dryness and purify by preparative TLC (10 % MeOH in CH 2 C1 2 ) to obtain the title compound. The preparation of the compounds of the present invention by the above-mentioned methods is illustrated further by the following examples, delineated in the TABLE which are not to be construed as limiting the invention in scope or spirit to the specific procedures and compounds described in them. Commonly used abbreviations are: Ph is phenyl, Me is methyl, Et is ethyl, Pr is n-propyl, iPr is isopropyl, cPr is cyclopropyl, Bu is butyl, iBu is isobutyl (CH 2 -CHMe 2 ), tBu is tert-butyl, cBu is cyclobutyl, Pent is n-pentyl, cPent is cyclopentyl, cHex is cyclohexyl, Py is pyridyl, Bn is benzyl (CH 2 Ph), Ac is acetyl (CH 3 - (C=O)), tBOC is tert-butyloxycarbonyl (tBuO-(C=0)). EX means example. 1 Tables of Examples 2 3 TABLE 1. ~4 Ul ~4 ~4 TABLE 3 3 1 2 TABLE 4 R 6 oo © TABLE 5 1 2 TABLE 6 4 R ismrthyl 00 Ui 5 6 W CN cn. TABLE 8 R° 00 TABLE 9 TABLE 10 oo 00 CN CN CN 1 2 CN cn 'cj- TABLE 15 R 6 -N, B I A. .R" N X FC NO ON Example 261 Characterization of NPY receptor interactions and in vivo function A. Assay for Human NPYi Receptor Binding Activity: Compounds are assayed for activity using the following method: A cDNA encoding human NPYI (SEQ ID NO:l) is ligated in the appropriate orientation for expression into the commercial expression vector pBacPAK9 (Clontech, Palo Alto, CA) for expression in SF9 cells. Each Baculoviral expression vector is co-transfected along with BACULOGOLD DNA (BD PharMingen, San Diego, CA) into S/9 cells. The S/9 cell culture supernatant is harvested three days post- transfection. The recombinant virus-containing supernatant is serially diluted in Hink's TNM-FH insect medium (JRH Biosciences, Kansas City) supplemented Grace's salts and with 4.1mM L-Gln, 3.3 g/L LAH, 3.3 g/L ultrafiltered yeastolate and 10% heat-inactivated fetal bovine serum (hereinafter "insect medium") and plaque assayed for recombinant plaques. After four days, recombinant plaques are selected and harvested into 1 ml of insect medium for amplification. Each 1 ml volume of recombinant baculovirus (at passage 0) is used to infect a separate T25 flask containing 2 x 10 6 S 9 cells in 5 mL of insect medium. After five days of incubation at 27°C, supernatant medium is harvested from each of the T25 infections for use as passage 1 inoculum. Recombinant baculoviral clones are then subjected to a second round of amplification, using 1 ml of passage 1 stock to infect 1 x 10 cells in 100 ml of insect medium divided into 2 T175 flasks. Forty-eight h post infection, passage 2 medium is harvested from each 100ml prep and plaque assayed for titer. The cell pellets from the second round of amplification are assayed for affinity binding of radiolabeled ligand (see below) to verify recombinant receptor expression. A third round of amplification is then initiated using an M.O.I, of 0.1 to infect a liter of S/9 cells. Forty h post-infection the supernatant medium is harvested to yield passage 3 baculoviral stock and the cell pellet assayed for affinity binding. Titer ofthe passage 3 baculoviral stock is determined by plaque assay and an M.O.I, and Incubation Time Course experiment is carried out to determine conditions for optimal receptor expression. Log-phase S 9 cells are infected with stocks of recombinant baculovirus encoding the proteins of interest (e.g., human NPYI and three g-proteins), followed by culturing in insect medium at 27°C. 72 h post-infection, a sample of cell suspension is analyzed for viability by trypan blue dye exclusion, and the remaining S/9 cells are harvested via centrifugation (3000 φm/ 10 minutes/ 4°C). B. Preparation of purified membranes: Sf9 cell pellets are resuspended in homogenization buffer (10 mM HEPES, 250 mM sucrose, 0.5 Dg/ml leupeptin, 2 Dg/ml Aprotinin, 200 DM PMSF, and 2.5 mM EDTA, pH 7.4) and homogenized using a POLYTRON homogenizer (setting 5 for 30 seconds). The homogenate is centrifuged (536 x g/ 10 minutes/ 4°C) to pellet the nuclei. The supernatant containing isolated membranes is decanted to a clean centrifuge tube, centrifuged (48,000 X g/ 30 minutes, 4°C) and resuspended in 30 ml, or preferably 20 ml of homogenization buffer. This centrifugation and resuspension step is repeated twice. The final pellet is resuspended in ice cold Dulbecco 's PBS containing 5 mM EDTA and stored in frozen aliquots until needed at -80°C. The protein concentration of the resulting membrane preparation is measured using the Bradford protein assay (Bio-Rad Laboratories, Hercules, CA). By this measure, a 1 -liter culture of cells typically yields 50-100 mg of total membrane protein. CO-infection for GTPγ 35 S binding assay: Four baculoviral expression vector stocks are used to infect a culture of S 9 cells with an MOI of 1 : 1 : 1 : 1. These four consisted of one vector encoding the human NPYI receptor and a different commercially obtained baculoviral expression vector stock encoding each of the three subunits of a heterotrimeric G-protein, in particular, the G-protein-encoding virus stocks are obtained from BIOSIGNAL Inc., Montreal, and are 1) a Gα G-protein subunit-encoding virus stock (either the rat Gα l2 G- protein-encoding virus stock BIOSIGNAL #V5J008 or the rat Gα 0 G-protein-encoding virus stock BIOSIGNAL #V5H010), 2) a bovine βl G-protein-encoding virus stock (BIOSIGNAL #V5H012), and 3) a human γ2 G-protein-encoding virus stock (BIOSIGNAL #V6B003). Agonist-stimulated GTPγ 35 S binding on purified membranes is assessed using hNPY 1-36 (American Peptide Co., Sunnyvale, CA) as agonist in order to ascertain functional activity as measured by GTPγ 35 S binding. GTPγ 35 S binding assay: Purified S 9 cell membranes are resuspended by Dounce homogenization (tight pestle) in GTPγ 35 S binding assay buffer (50 mM Tris pH 7.0, 120 mM NaCl, 2 mM MgC12, 2 mM EGTA, 0.1% BSA, 0.1 mM bacitracin, lOOKIU/mL Aprotinin, 5 μM GDP) and added to reaction tubes at a concentration of 30 μg/reaction tube. After adding increasing doses ofthe agonist hNPY 1-36 (American Peptide Co., Sunnyvale, CA), reactions are initiated by the addition of 100 pM GTPγ S. Following a 30-minute incubation at ambient temperature, the reactions are terminated by vacuum filtration over GF/C filters (presoaked in wash buffer, 0.1% BSA) followed by washing with ice-cold wash buffer (50 mM Tris pH 7.0, 120mM NaCl). Bound GTPγ S is determined by liquid scintillation spectrometry ofthe washed filters. Nonspecific binding is determined using 10 mM GTPγS. Data are generally expressed as % maximal response and are derived by determining the maximal agonist stimulated % above basal stimulation. Computer analysis may be conveniently used to calculate estimated EC 50 , 3 5 IC 50 and K, values from GTPγ S binding experiment data, e.g., using SigmaPlot software. The binding affinity for the preferred compounds of the invention, expressed as K, values, ranges from about 0.1 nanomolar to about 5 micromolar. Particularly preferred compounds yield a K, value of less than 100 nanomolar, most preferably less than 10 nanomolar . Assay for affinity binding of radiolabeled ligand: Purified membranes are washed with PBS and re-suspended by gentle pipetting in binding buffer (50 mM Tris(HCl), 5 mM KC1, 120 mM NaCl, 2 mM CaC12, 1 mM MgC12, 0.1% bovine serum albumin (BSA), pH 7.4). Membranes (5μg) are added to siliconized (Sigmacote, Sigma) polypropylene tubes in addition to 0.050 nM [125I]NPY (porcine, New England Nuclear Corp., Boston, MA) for competition analysis or 0.010-0.500 nM [125I]NPY (porcine) for saturation analysis. For evaluation of guanine nucleotide effects on receptor affinity, GTP is added at a final concentration of 100 μM. Cold displacers are added at concentrations ranging from 10-12 M to 10-6 M to yield a final volume of 0.250 mL. Nonspecific binding is determined in the presence of 1 μM NPY (human, American Peptide Co., Sunnyvale, CA) and accounts for less than 10% of total binding. Following a 2-hour incubation at ambient temperature, the reaction is terminated by rapid vacuum filtration. Samples are filtered over presoaked GF/C Whatman filters (1.0% polyethyleneimine for 2 hours) and rinsed 2 times with 5 mL cold binding buffer lacking BSA. Remaining bound radioactivity is measured by gamma counting. To estimate the Bmax, Kd and Ki, the results of binding experiments are analyzed using SigmaPlot software (SPSS Science, Chicago, IL). The binding affinity for the compounds of the invention, expressed as a Ki value, ranges from about 0.1 nanomolar to about 10 micromolar. The most preferred compounds of the invention have a Ki of less than 100 nanomolar and a binding selectivity of > 100-fold relative to other G-protein coupled receptors, including NPY 5 and CRFi receptors. C. In vivo analysis - Food Deprivation Subjects. Experimentally naive and experienced male Sprague-Dawley rats (Sasco, St. Louis, MO) weighing 210-300g at the beginning of the experiment are used. Animals are triple-housed in stainless steel hanging cages in a temperature (22 C ± 2 ) and humidity (40-70% RH) controlled animal facility with a 12:12 hour light-dark cycle. Food (Standard Rat Chow, PMI Feeds Inc., #5012) and water are available ad libitum. Apparatus. Consumption data is collected while the animals are housed in Nalgene Metabolic cages (Model #650-0100). Each cage is comprised of subassemblies made of clear polymethlypentene (PMP), polycarbonate (PC), or stainless steel (SS). All parts disassemble for quick and accurate data collection and for cleaning. The entire cylinder-shaped plastic and SS cage rests on a SS stand and houses one animal. The animal is contained in the round Upper Chamber (PC) assembly (12cm high and 20cm in diameter) and rests on a SS floor. Two subassemblies are attached to the Upper Chamber. The first assembly consists of a SS feeding chamber (10cm long, 5cm high and 5cm wide) with a PC feeding drawer attached to the bottom. The feeding drawer has two compartments: a food storage compartment with the capacity for approximately 50g of pulverized rat chow, and a food spillage compartment. The animal is allowed access to the pulverized chow by an opening in the SS floor of the feeding chamber. The floor of the feeding chamber does not allow access to the food dropped into the spillage compartment. The second assembly includes a water bottle support, a PC water bottle (100ml capacity) and a graduated water spillage collection tube. The water bottle support funnels any spilled water into the water spillage collection tube. The lower chamber consists of a PMP separating cone, PMP collection funnel, PMP fluid (urine) collection tube, and a PMP solid (feces) collection tube. The separating cone is attached to the top of the collection funnel, which in turn is attached to the bottom of the Upper Chamber. The urine runs off the separating cone onto the walls of the collection funnel and into the urine collection tube. The separating cone also separates the feces and funnels it into the feces collection tube. Food consumption, water consumption, and body weight may be measured with an Ohaus Portable Advanced scale (±0.1 g accuracy). Procedure. Prior to the day of testing, animals are habituated to the testing apparatus by placing each animal in a Metabolic cage for 1 hour. On the day of the experiment, animals that have been food deprived the previous night are weighed and assigned to treatment groups. Assignments are made using a quasi-random method utilizing the body weights to assure that the treatment groups had similar average body weight. Animals are then administered either vehicle (0.5% methyl cellulose) or drug (a compound of the invention). At that time, the feeding drawer is filled with pulverized chow, the filled water bottle, and the empty urine and feces collection tubes are weighed. Two h after drug treatment, each animal is weighed and placed in a Metabolic Cage. Following a one-hour test session, animals are removed and body weight obtained. The food and water containers are then weighed and the food and water consumption data recorded. Drugs. Drug suspended in vehicle, or vehicle alone as a control, is administered orally (PO) using a gavage tube connected to a 3 or 5ml syringe at a volume of lOml/kg. Drug is made into a homogenous suspension by stirring and ultrasonicating for at least 1 hour prior to dosing. Statistical Analyses. The means and standard errors of the mean (SEM) for food consumption, water consumption, and body weight change are obtained. One-way analysis of variance using Systat (5.2.1) is used to test for group differences. A significant effect is defined as having a p value of <.05. The following parameters are defined: Body weight change is the difference between the body weight of the animal immediately prior to placement in the metabolic cage and its body weight at the end of the one hour test session. Food consumption is the difference in the weight of the food drawer prior to testing and the weight following the 1-hour test session. Water consumption is the difference in the weight of the water bottle prior to testing and the weight following the 1-hour test session. Preferred compounds of the invention reduce food intake and body weight gain, preferably to a statistically significant degree as determined by standard parametric analysis such as a student's T-test. Example 262 Preparation of radiolabeled probe compounds ofthe invention The compounds of the invention are prepared as radiolabeled probes by carrying out their synthesis using precursors comprising at least one atom that is a radioisotope. The radioisotope is preferably selected from of at least one of carbon (preferably 14 C), hydrogen (preferably 3 H), sulfur (preferably 35 S), or iodine (preferably 125 I). Such radiolabeled probes are conveniently synthesized by a radioisotope supplier specializing in custom synthesis of radiolabeled probe compounds. Such suppliers include Amersham Corporation, Arlington Heights, IL; Cambridge Isotope Laboratories, Inc. Andover, MA; SRI International, Menlo Park, CA; Wizard Laboratories, West Sacramento, CA; ChemSyn Laboratories, Lexena, KS; American Radiolabeled Chemicals, Inc., St. Louis, MO; and Moravek Biochemicals Inc., Brea, CA. Tritium labeled probe compounds are also conveniently prepared catalytically via platinum-catalyzed exchange in tritiated acetic acid, acid-catalyzed exchange in tritiated trifluoroacetic acid, or heterogeneous-catalyzed exchange with tritium gas. Such preparations are also conveniently carried out as a custom radiolabeling by any of the suppliers listed in the preceding paragraph using the compound of the invention as substrate. In addition, certain precursors may be subjected to tritium-halogen exchange with tritium gas, tritium gas reduction of unsaturated bonds, or reduction using sodium borotritide, as appropriate. Example 263 Receptor autoradiographv Receptor autoradiography (receptor mapping) is carried out in vitro as described by Kuhar in sections 8.1.1 to 8.1.9 of Current Protocols in Pharmacology (1998) John Wiley & Sons, New York, using radiolabeled compounds of the invention prepared as described in the preceding Example. The invention and the manner and process of making and using it, are now described in such full, clear, concise and exact terms as to enable any person skilled in the art to which it pertains, to make and use the same. It is to be understood that the foregoing describes preferred embodiments of the present invention and that modifications may be made therein without departing from the spirit or scope of the present invention as set forth in the claims. To particularly point out and distinctly claim the subject matter regarded as invention, the following claims conclude this specification.

Claims: WHAT IS CLAIMED IS: 1. A compound selected from Formula I-XV, II III IV VI VII VIII IX XI XII XIII XIV XV or a pharmaceutically acceptable salt thereof, wherein X is N or CR 14 ; W is S, O, or NR 15 ; Y is N or CR J ; E, F, and G are each, independently, CR 3 or N; I and J are each, independently, C=O, S, O, CR 3 R 16 or NR 15 when single bonded to both adjacent ring atoms, or N, or CR 3 when double bonded to an adjacent ring atom; K is N or CR when double bonded to L or J, or O, S, C=O, CR 3 R 16 , or NR 15 when single bonded to both adjacent ring atoms, or N or CR 3 when double bonded to an adjacent ring atom; L is N or CR 16 when single bonded to all atoms to which it is attached, or C (carbon) when double bonded to K; the 6- or 7-membered ring that contains I, J, K, and L may contain from 1 to 3 double bonds, from 0 to 2 heteroatoms, and from 0 to 2 C=O groups, wherein the carbon atom of such groups are part ofthe ring and the oxygen atom is a substituent on the ring; Q is O or NR 15 ; R 1 is selected from H, Cι-C 6 alkyl, C 3 -C] 0 cycloalkyl, (C 3 -C10 cycloalkyl) C r C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cyano, halo, C,-C 6 haloalkyl, OR 7 , d-C 6 alkyl-OR 7 ; C,-C 6 cyanoalkyl, NR 8 R 9 , Cι-C 6 alkyl-NR 8 R 9 ; R 2 is H, Cι-C 6 alkyl which optionally forms a C 3 -C 6 aminocarbocycle or a C 2 -C 5 aminoheterocycle with A or B, each optionally substituted at each occurrence with R 7 , C 3 -Cιo cycloalkyl, or (C3-C10 cycloalkyl) C C 6 alkyl; or R 2 and R 6 jointly form with the 2 nitrogen atoms to which they are bound a C 2 -C 5 aminoheterocycle optionally substituted at each position with R 7 ; A is (CH 2 ) m where m is 1,2 or 3 and is optionally mono- or di-substituted on each occurrence with Cι-C 6 alkyl, C 3 -C 10 cycloalkyl, (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl, Cι-C 6 alkenyl, C,-C 6 alkynyl, cyano, halo, Cι-C 6 haloalkyl, OR 7 , C C 6 alkyl-OR 7 ; C,-C 6 cyanoalkyl, NR 8 R 9 , Cι-C 6 alkyl-NR 8 R 9 , or A and B jointly form a C 3 -C 6 carbocycle, optionally substituted at each position with R 7 or, A and R 2 jointly form a C 3 -C 6 aminocarbocycle or a C 2 -C 5 aminoheterocycle optionally substituted at each position with R 7 ; B is (CH 2 ) n where n is 1,2 or 3 and is optionally mono- or di-substituted on each carbon atom with Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cyano, halo, Cι-C 6 haloalkyl, OR 7 , Cι-C 6 alkyl-OR 7 ; Cι-C 6 cyanoalkyl, NR 8 R 9 , Ci -C 6 alkyl-NR 8 R 9 , or B and R 2 jointly form a C 3 -C 6 aminocarbocycle or a C 2 -C 5 aminoheterocycle optionally substituted at each position with R ; R 3 and R 16 are independently selected at each occurrence from H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cyano, halogen, C,-C 6 haloalkyl, OR 7 , C C 6 alkyl-OR 7 , C C 6 cyanoalkyl, NR 8 R 9 , C,-C 6 alkyl-NR 8 R 9 ; R 4 is selected from aryl or heteroaryl, each optionally substituted with 1 to 5 substituents independently selected at each occurrence from Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, C -Cι 0 cycloalkenyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, Cι-C 6 alkenyl, halogen, Cι-C 6 haloalkyl, trifluromethylsulfonyl, OR 7 , Ci-Cc alkyl-OR 7 , NR 8 R 9 , C,-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , C,-C 6 alkyl-CONR 8 R 9 , COOR 7 , C,-C 6 alkyl-COOR 7 , CN, C,-C 6 alkyl- CN, SO 2 NR 8 R 9 , SO 2 R 7 , aryl, heteroaryl, heterocycloalkyl, 3-, 4-, or 5-(2-oxo-l,3- oxazolidinyl), with the proviso that at least one of the positions ortho or para to the point of attachment of the aryl or heteroaryl ring to the heterocyclic core is substituted; R 5 is selected from: Cι-C 6 alkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, each of which is substituted with 1 to 5 groups independently selected at each occurrence from halo, C,-C 2 haloalkyl, OR 7 , cyano, NR 8 R 9 , CONR 8 R 9 , COOR 7 , SO 2 NR 8 R 9 , SO 2 R 7 , NR π COR 12 , NR n SO 2 R 7 ; Cι-C 6 arylalkyl, Cι-C 6 heteroarylalkyl, C 5 -C 8 arylcycloalkyl, or Cs-Cg heteroarylcycloalkyl, where aryl is phenyl or naphthyl, and heteroaryl is 2-,3-, or 4-pyridyl, 2-, 4- or 5- pyrimidinyl, triazinyl, 1-, 2- or 4-imidazolyl, 2-, 4-, or 5-oxazolyl, isoxazolyl, indolyl, pyrazolyl, quinolyl, isoquinolyl, 2-, 4-, or 5-thiazolyl, benzothiadiazolyl, 1-, 3- or 4- pyrazolyl, 1-, 3- or 4-triazolyl, 2-triazinyl, 2-pyrazinyl, 2-, or 3-furanyl, 2-, or 3- thienyl, 2-, or 3-benzothienyl, or 1-, 2- or 5-tetrazolyl, each of which is optionally substituted with 1 to 5 substituents independently selected at each occurrence from Cι-C 6 alkyl, C -Cι 0 cycloalkyl, C 3 -Cι 0 cycloalkenyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C,-C 6 alkenyl, halogen, Cι-C 6 haloalkyl, trifluromethylsulfonyl, OR 7 , NR 8 R 9 , Cι-C 6 alkyl-OR 7 , C,-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, SO 2 NR 8 R 9 , SO 2 R 7 , aryl, heteroaryl, heterocycloalkyl, 3-, 4-, or 5-(2-oxo-l,3-oxazolidinyl), with the proviso that 2 adjacent substituents can optionally form together a C 3 -Cι 0 cycloalkyl ring, a C 3 -Cιo cycloalkenyl ring or a heterocycloalkyl ring; C 3 -Cιo cycloalkyl, (C3-C1 0 cycloalkyl) Cι-C 6 alkyl, C 3 -Cι 0 cycloalkenyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, each of which is optionally with 1 to 6 substituents independently selected at each occurrence from Cι-C 6 alkyl, C 3 -Cι 0 cycloalkyl, C 3 -Cιo cycloalkenyl, (C 3 -Cι 0 cycloalkyl) d-C 6 alkyl, C,-C 6 alkenyl, halogen, Cι-C 6 haloalkyl, OR 7 , NR 8 R 9 , with the proviso that when two OR 7 or NR 8 R 9 substituents are geminally located on the same carbon R 7 is not H and they can form together a C 2 -C 4 ketal, oxazoline, oxazolidine, imidazoline, or imidazolidine heterocycle, Cι-C 6 alkyl-OR 7 , Cι-C 6 alkyl- NR. 8 R 9 , CONR 8 R 9 , COOR 7 , CN, oxo, hydroximino, C,-C 6 alkoximino, SO 2 N 8 R 9 , SO 2 R 7 , heterocycloalkyl, aryl, heteroaryl, where aryl or heteroaryl is optionally substituted with 1 to 5 substituents independently selected at each occurrence from Cι-C 6 alkyl, C 3 - o cycloalkyl, C 3 -Cι 0 cycloalkenyl, (C 3 -C 10 cycloalkyl) Cι-C 6 alkyl, Ci-Cβ alkenyl, halogen, C C 6 haloalkyl, trifluromethylsulfonyl, OR 7 , NR 8 R 9 , C C 6 alkyl-OR 7 , C,-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, SO 2 NR 8 R 9 , SO 2 R 7 , aryl, heteroaryl, heterocycloalkyl, 3-, 4-, or 5-(2-oxo-l,3-oxazolidinyl), with the proviso that 2 adjacent substituents can optionally form together a C 3 -Cι 0 cycloalkyl ring, a C 3 -Cιo cycloalkenyl ring or a heterocycloalkyl ring; aryl or heteroaryl, optionally substituted with 1 to 5 substituents independently selected at each occurrence from halogen, Cι-C 6 alkyl, C 3 -Cι 0 cycloalkyl, C -Cιo cycloalkenyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, Cι-C 6 alkenyl, halogen, Cι-C 6 haloalkyl, trifluromethylsulfonyl, OR 7 , NR 8 R 9 , d -C 6 alkyl-OR 7 , C 1 -C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, SO 2 NR 8 R 9 , SO 2 R 7 , aryl, heteroaryl, heterocycloalkyl, 3-, 4-, or 5-(2- oxo-l,3-oxazolidinyl), with the proviso that 2 adjacent substituents can optionally form together a C 3 -Cι 0 cycloalkyl ring, a C 3 -Cι 0 cycloalkenyl ring or a heterocycloalkyl ring; or 3- or 4-piperidinyl, 3-pyrrolidinyl, 3- or 4- tetrahydropyranyl, 3-tetrahydrofuranyl, 3- or 4- tetrahydropyranyl, 3-tetrahydrofuranyl, 3- or 4-tetrahydrothiopyranyl, 3- or 4-(l,l- dioxo) tetrahydrothiopyranyl, l-azabicyclo[4.4.0]decyl, 8-azabicyclo[3.2.1]octanyl, norbornyl, quinuclidinyl, each optionally substituted with 1 to 5 substituents independently selected at each occurrence from R 7 , Cι-C 6 alkyl-OR 7 , Cι-C 6 alkyl- NR 8 R 9 , CONR 8 R 9 , COOR 7 ; R 6 is selected from H, Cι-C 6 alkyl, C 3 -C, 0 cycloalkyl, (C 3 -Cι 0 cycloalkyl) d-C 6 alkyl, C 2 -C 4 alkenyl, Cι-C 6 arylalkyl, Cι-C 6 heteroarylalkyl where aryl or heteroaryl are optionally substituted with 1 to 5 substituents independently selected at each occurrence from halogen, C,-C 6 haloalkyl, OR 13 , NR 8 R 9 , C,-C 6 alkyl-OR 13 , Cι-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 7 , CN, SO 2 NR 8 R 9 , SO 2 R 7 , or R° and R 2 , as mentioned above, jointly form, with the 2 nitrogen atoms to which they are bound, a C 2 -C 5 aminoheterocycle optionally substituted at each position with R 7 ; R 7 is H, Cι-C 6 alkyl, C -Cιo cycloalkyl, C 3 -Cι 0 cycloalkenyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, C,-C 3 haloalkyl, or heterocycloalkyl, Cι-C 8 alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, Cι-C 8 alkanoyl, aroyl, heteroaroyl, aryl, heteroaryl, Cι-C 6 arylalkyl or Cι-C 6 heteroarylalkyl each optionally substituted with 1 to 5 substituents independently selected at each occurrence from halogen, C,-C 6 haloalkyl, OR 13 , NR 8 R 9 , Cι-C 6 alkyl-OR 13 , Cι-C 6 alkyl-NR 8 R 9 , CONR 8 R 9 , COOR 13 , CN, SO 2 NR 8 R 9 , SO 2 R 13 , with the proviso that when R 7 is SO 2 R 13 , R 13 cannot be H; R 8 and R 9 are independently selected at each occurrence from H, CpC 6 alkyl, C -Cιo cycloalkyl, C 2 -C 6 alkenyl, C -Cι 0 cycloalkenyl, C 2 -C 6 alkynyl, heterocycloalkyl, Ci- C 8 alkanoyl, aroyl, heteroaroyl, aryl, heteroaryl, Cι-C 6 arylalkyl or Cι-C 6 heteroarylalkyl, or R 8 and R 9 , taken together, can form a C 3 -C 6 aminocarbocycle or a C 2 -C 5 aminoheterocycle each optionally substituted at each occurrence with with Cj- C 6 alkyl, C 3 -C] 0 cycloalkyl, C 3 -C 10 cycloalkenyl, (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl, C\- C 3 haloalkyl, or heterocycloalkyl, Cι-C 8 alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, Cι-C 8 alkanoyl, aroyl, heteroaroyl, aryl, heteroaryl, Cι-C 6 arylalkyl or C]-C 6 heteroarylalkyl; R 11 is selected from H, Cι-C 6 alkyl, C -C) 0 cycloalkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl; R 12 is selected from H, aryl, heteroaryl, Cι-C 6 alkyl, C -Cιo cycloalkyl, (C 3 -Cι 0 cycloalkyl) Ci-C δ alkyl, optionally substituted with OR 7 , NR 8 R 9 , C 3 -C 6 aminocarbocycle, or C 2 - C 5 aminoheterocycle; R 13 is independently selected at each occurrence from H, Cι-C 6 alkyl, C 3 -C] 0 cycloalkyl, (C - Cio cycloalkyl) Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, Cι-C 6 haloalkyl, with the proviso that for SO 2 NR 8 R 9 , SO 2 R 13 , R 13 cannot be H; R 14 is H, Cι-C 6 alkyl, C 3 -C, 0 cycloalkyl, (C 3 -C, 0 cycloalkyl) Cι-C 6 alkyl, C 2 -C 4 alkenyl, C 2 - C 4 alkynyl, halo, or CN; and R 15 is selected at each occurrence from H, Cι-C 6 alkyl, C -Cιo cycloalkyl, (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 2 -C 6 alkyl-OR 7 , C 2 -C 6 cyanoalkyl, C 2 -C 6 alkyl-NR 8 R 9 . 2. A compound as claimed in claim 1 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - Cio cycloalkyl, or (C 3 -Cι 0 cycloalkyl) Cj-C 6 alkyl; R 6 is H, Cι-C 6 alkyl, C 3 -C1 0 cycloalkyl, or (C 3 -Cιo cycloalkyl) C,-C 6 alkyl. 3. A compound as claimed in claim 1 having the formula: Formula I wherein A, B, E, F, G, X, R 1 , R 2 , R 4 , R 5 , and R 6 are as defined in claim 1. 4. A compound as claimed in claim 3 wherein X is N or CH, R , ι i •s H, Cι-C 6 alkyl, C 3 - Cio cycloalkyl, or (C3-C1 0 cycloalkyl) Cι-C 6 alkyl; R 6 is H, Cι-C 6 alkyl, C 3 -Cι 0 cycloalkyl, (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 5. A compound as claimed in claim 3 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. 6 A compound as claimed in claim 1 having the formula: R 6 Formula II wherein A, B, X, R 1 , R 2 , R 4 , R 5 , R 6 and R 16 are as defined in claim 1. 7. A compound as claimed in claim 6 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl; R 6 is H, C C 6 alkyl, C 3 -Cι 0 cycloalkyl, or (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 8. A compound as claimed in claim 6 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. 9. A compound as claimed in claim 1 having the formula: Formula III wherein A, B, X, W, R 1 , R 2 , R 4 , R 5 , and R 6 are as defined in claim 1. 10. A compound as claimed in claim 9 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - Cio cycloalkyl, or (C 3 -C ]0 cycloalkyl) Cι-C 6 alkyl; R 6 is H, d-C 6 alkyl, C 3 -Cι 0 cycloalkyl, or (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 11. A compound as claimed in claim 9 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen.. 12. A compound as claimed in claim 1 having the formula Formula IV wherein A, B, X, R 1 , R 2 , R 4 , R 5 , and R 6 are as defined in claim 1. 13. A compound as claimed in claim 12 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - Cio cycloalkyl, or (C 3 -C, 0 cycloalkyl) Cι-C 6 alkyl; R 6 is H, d-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C -Cιo cycloalkyl) Cι-C 6 alkyl phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 14. A compound as claimed in claim 12 wherein R ,4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen.. 15. A compound as claimed in claim 1 having the formula Formula V wherein A, B, X, R 1 , R 2 , R 4 , R 5 , and R 6 are as defined in claim 1. 16. A compound as claimed in claim 15 wherein X is N or CH, R 1 is H, CpC 6 alkyl, C 3 - Cio cycloalkyl, or (C3-C10 cycloalkyl) Cι-C 6 alkyl; R 6 is H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 17. A compound as claimed in claim 15 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. .18. A compound as claimed in claim 1 having the formula Formula VI wherein A, B, X, R 1 , R 2 , R 4 , R 5 , and R° are as defined in claim 1. 19. A compound as claimed in claim 18 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - Cio cycloalkyl, or (C3-C10 cycloalkyl) Cι-C 6 alkyl; and R 6 is H, Cι-C 6 alkyl, C 3 -Cι 0 cycloalkyl, or (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 20. A compound as claimed in claim 18 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. .21. A compound as claimed in claim 1 having the formula Formula VII wherein A, B, X, R 1 , R 2 , R 4 , R 5 , R 6 and R 15 are as defined in claim 1. 22. A compound as claimed in claim 21 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - C10 cycloalkyl, or (C3-C10 cycloalkyl) C,-C 6 alkyl; and R 6 is H, Cι-C 6 alkyl, C 3 -Cι 0 cycloalkyl, or (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 23. A compound as claimed in claim 21 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. .24. A compound as claimed in claim 1 having the formula Formula VIII wherein A, B, X, R 1 , R 2 , R 4 , R 5 , R 6 and R 15 are as defined in claim 1. 25 A compound as claimed in claim 24 wherein X is N or CH, R is H, Cι-C 6 alkyl, C 3 - Cio cycloalkyl, or (C 3 -C 10 cycloalkyl) Cι-C 6 alkyl; and R 6 is H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C -Cιo cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 26. A compound as claimed in claim 24 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. .27 A compound as claimed in claim 1 having the formula R 5 R 6 -N. B - R2 R 4 Formula IX wherein A, B, X, R 1 , R 2 , R 4 , R 5 , and R 6 are as defined in claim 1. 28. A compound as claimed in claim 27 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C - Cio cycloalkyl, or (C 3 -C10 cycloalkyl) Cι-C 6 alkyl; and R° is H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 29. A compound as claimed in claim 27 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. .30. A compound as claimed in claim 1 having the formula Formula X wherein A, B, X, R 1 , R 2 , R 4 , R 5 , and R° are as defined in claim 1. 31. A compound as claimed in claim 30 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - C10 cycloalkyl, or (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl; and R 6 is H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C 3 -Cιo cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 32. A compound as claimed in claim 30 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. .33. A compound as claimed in claim 1 having the formula Formula XI wherein A, B, X, R 1 , R 2 , R 4 , R 5 , R 6 and R15 are as defined in claim 1. 34. A compound as claimed in claim 33 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - do cycloalkyl, or (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl; and R 6 is H, Ci-Cό alkyl, C 3 -Cι 0 cycloalkyl, or (C -Cι 0 cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 35. A compound as claimed in claim 3 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. 36. A compound as claimed in claim 1 having the formula Formula XII wherein A, B, X, R 1 , R 2 , R 4 , R 5 , R 6 and R16 are as defined in claim 1. 37. A compound as claimed in claim 36 wherein X is N or CH, R is H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C -Cι 0 cycloalkyl) Cι-C 6 alkyl; and R 6 is H, Cι-C 6 alkyl, C3-C10 cycloalkyl, or (C 3 -C 10 cycloalkyl) d-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 38. A compound as claimed in claim 36 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. 39. A compound as claimed in claim 1 having the formula Formula XIII wherein A, B, W, X, R 1 , R 2 , R 4 , R 5 , R 6 and 16 are as defined in claim 1. 40. A compound as claimed in claim 39 wherein X is N or CH, R is H, Cι-C 6 alkyl, C 3 - do cycloalkyl, or (C 3 -Cιo cycloalkyl) d-C 6 alkyl; and R 6 is H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 41. A compound as claimed in claim 39 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. 42. A compound as claimed in claim 1 having the formula Formula XIV wherein A, B, W, X, I, J, K, L, R 1 , R 2 , R 4 , R 5 , and R 6 are as defined in claim 1. 43. A compound as claimed in claim 42 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - Cio cycloalkyl, or (C 3 -Cι 0 cycloalkyl) Cι-C 6 alkyl; and R 6 is H, Cι-C 6 alkyl, C 3 -Cιo cycloalkyl, or (C 3 -Cιo cycloalkyl) C C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 44. A compound as claimed in claim 42 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. 45. A compound as claimed in claim 1 having the formula Formula XV wherein A, B, Q, X, Y, R 1 , R 2 , R , R 5 , and R 6 are as defined in claim 1. 46. A compound as claimed in claim 45 wherein X is N or CH, R 1 is H, Cι-C 6 alkyl, C 3 - Cio cycloalkyl, or (C3-C 1 0 cycloalkyl) C,-C 6 alkyl; and R 6 is H, C,-C 6 alkyl, C 3 -C ]0 cycloalkyl, or (C -Cιo cycloalkyl) Cι-C 6 alkyl, phenethyl optionally substituted with one or two substituents selected from alkyl and alkoxy, tetrahydropyranyl and piperidinyl optionally substituted by a heterocycle. 46. A compound as claimed in claim 45 wherein R 4 is phenyl, optionally substituted in one, two or three positions by alkyl, alkoxy or halogen. 47. A pharmaceutical comprising a compound as claimed in claim 1 for the treatment of disorders or disease states caused by eating disorders, of obesity, bulimia nervosa, diabetes, dislipidemia, hypertension, memory loss, epileptic seizures, migraine, sleep disorders, pain, sexual/reproductive disorders, depression, anxiety, cerebral hemorrhage, shock, congestive heart failure, nasal congestion or diarrhea.. 48. A method of selectively inhibiting binding of NPYi receptors, which comprises contacting a compound of claim 1 with neuronal cells, wherein the compound is present in an amount effective to produce a concentration sufficient to selectively inhibit binding of NPYi receptors in vitro. 49. A method of treating a physiological disorder or disease selected from the group consisting of disorders or diseases pertaining to the heart, blood vessels or the renal system, such as vasospasm, heart failure, shock, cardiac hypertrophy increased blood pressure, angina, myocardial infarction, sudden cardiac death, arrhythmia, peripheral vascular disease, and abnormal renal conditions such as impaired flow of fluid, abnormal mass transport, or renal failure; conditions related to increased sympathetic nerve activity for example, during or after coronary artery surgery, and operations and surgery in the gastrointestinal tract; cerebral diseases and diseases related to the central nervous system, such as cerebral infarction, neurodegeneration, epilepsy, stroke, and conditions related to stroke, cerebral vasospasm and hemorrhage, depression, anxiety, schizophrenia, and dementia; conditions related to pain or nociception; diseases related to abnormal gastrointestinal motility and secretion, such as different forms of ileus, urinary incontinence, and Crohn's disease; abnormal drink and food intake disorders, such as obesity, anorexia, bulimia, and metabolic disorders; diseases related to sexual dysfunction and reproductive disorders; conditions or disorders associated with inflammation; respiratory diseases, such as asthma and conditions related to asthma and bronchoconstriction; and diseases related to abnormal hormone release, such as leutinizing hormone, growth hormone, insulin, and prolactin, which comprises administering to a person sufferring form such disorder or disease a therapeutically efective amount of a compound as climed in claim 1. 50. A method of converting heterocyclic cores of formula Ia to XVa Va Via Vila Villa Ixa Xa XIa Xlla Xllla XlVa XVa where X, E, F, G, W, I, J, K, L, Q, R 1 , R 3 , R 4 , R 15 and R 16 are defined per Claim 1, into compounds that potently and selectively interact with NPYi receptors by substituting the n- position of heterocycles of formula Ia - XVIa with a diamine group of formula N[R 2 ]-A-B- N[R 6 ]-R 5 where R 2 , A, B, R 6 , and R 5 are defined per Claim 1. 51. A method of treating obesity comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of formula as defined in claim 1 or a prodrug thereof or a pharmaceutically acceptable salt of said compound or of said prodrug. 52. A method as recited in claim 51 wherein the amount of a compound as defined in claim 1 is about 0.01 mg/kg/day to about 140 mg/kg/day. 53. A method as recited in claim 51 wherein the mammal is female or male human. 54. A pharmaceutical composition which comprises a therapeutically effective amount of compound of claim 1 or a prodrug thereof or a pharmaceutically acceptable salt of said compound or of said prodrug and a pharmaceutically acceptable carrier, vehicle or diluent. 55. A pharmaceutical composition for the treatment of obesity which comprises a therapeutically effective amount of compound of claim 1 or a prodrug thereof or a pharmaceutically acceptable salt of said compound or of said prodrug and a pharmaceutically acceptable carrier, vehicle or diluent. 56. A pharmaceutical combination composition comprising a therapeutically effective amount of a composition comprising: (a) first compound, said first compound being a compound of claim 1, a prodrug thereof, or a pharmaceutically acceptable salt of said compound or of said prodrug; and (b) a second compound, said second compound being a β 3 agonist, a thyromimetic, an eating behavior modifying agent or a NPY antagonist; and a pharmaceutical carrier, vehicle, diluent. 57 A method of treating obesity comprising administering to a mammal in need of such treatment: (a) first compound, said first compound being a compound of claim 1, a prodrug thereof, or a pharmaceutically acceptable salt of said compound or of said prodrug; and (b) a second compound, said second compound being a β 3 agonist, a thyromimetic, an eating behavior modifying agent or a NPY antagonist; and a pharmaceutical carrier, vehicle, diluent; (and (c) wherein the amounts ofthe first and second compounds result in a therapeutic effect. 58. A kit comprising: (a) first compound, said first compound being a compound of claim 1, a prodrug thereof, or a pharmaceutically acceptable salt of said compound or of said prodrug; (b) a second compound, said second compound being a β 3 agonist, a thyromimetic, an eating behavior modifying agent or a NPY antagonist; and a pharmaceutical carrier, vehicle, diluent; and (c) means for containing said first and second unit dosage forms wherein the amounts ofthe first and second compounds result in a therapeutic effect. 59. A pharmaceutical combination composition comprising a therapeutically effective amount of a composition comprising (a) first compound, said first compound being a compound of claim 1, a prodrug thereof, or a pharmaceutically acceptable salt of said compound or of said prodrug; (b) a second compound, said second compound being an aldose reductase inhibitor, a glycogen phosphorylase inhibitor, a sorbitol dehydrogenase inhibitor, insulin, metformin, acarbose, a thiazolidinedione, a glitazone, rezulin, trogitalazone, a sulfonylurea, glipazide, glyburide, or chlo ropamide; (c) a pharmaceutical carrier, vehicle, or diluent. 60. A pharmaceutical composition comprising a compound as defined in claim 1 for the treatment of disorders or disease states caused by eating disorders, of obesity, bulimia nervosa, diabetes, dislipidemia, hypertension, memory loss, epileptic seizures, migraine, sleep disorders, pain, sexual/reproductive disorders, depression, anxiety, cerebral hemorrhage, shock, congestive heart failure, nasal congestion or diarrhea. 61. A method of selectively inhibiting binding of NPYi receptors, which comprises contacting a compound of claim 1 with neuronal cells, wherein the compound is present in an amount effective to produce a concentration sufficient to selectively inhibit binding of NPY peptides to NPYi receptors in vitro. 62. A compound of claim 1 of formula I and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of : a compound of formula I wherein X is CH or N, R 1 is methyl, R 2 is H, E is CH, F is CH, G is CH, R 4 is 2,4,6-trimethylphenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-cyclopentyl; a compound of formula I wherein X is CH or N, R is methyl, R is H, E is CH, F is CH, G is CH, R 4 is 2,6-dichlorophenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-cyclopentyl; a compound of formula I wherein X is CH or N, R 1 is methyl, R 2 is H, E is CH, F is CH, G is CH, R 4 is 2,4,6-trimethylphenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(tetrahydropyran-4-yl); a compound of formula I wherein X is CH or N, R 1 is methyl, R 2 is H, E is CH, F is CH, G is CH, R 4 is 2,6-dichlorophenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(tetrahydropyran-4-yl); a compound of formula I wherein X is CH or N, R 1 is methyl, R 2 is H, E is CH, F is CH, G is CH, R 4 is 2,4,6-trimethylphenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(l-(pyrimidin-2-yl)-piperidin- 4-yl); a compound of formula I wherein X is CH or N, R 1 is methyl, R 2 is H, E is CH, F is CH, G is CH, R 4 is 2,6-dichlorophenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(l-(pyrimidin-2-yl)-piperidin-4- yi); a compound of formula I wherein X is CH or N, R 1 is methyl, R 2 is H, E is CH, F is CH, G is CH, R 4 is 2,4,6-trimethylphenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(CH 2 ) 2 -(3 ,4-dimethoxyphenyl). 63. A compound of claim 1 of formula II and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me e, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula II wherein X is N, R is Me, R is H, R 16 is Me, R is 2,4,6 trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R is 2,4,6- ttrriimmeetthhyyllpphheennyyll,, I R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula II wherein X is CH, R is Me, R is H, R 16 is Me, R is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula II wherein X is CH, R is Me, R is H, R 16 is Me, R is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula II wherein X is CH, R 1 is Me, R is H, R 16 is Me, R is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethy 1 ; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is tetrahydropyranyl; a compound of formula II wherein X is N, R is Me, R is H, R is Me, R is 2,6-dichloro-4 mmeetthhooxxyypphheennyyll,, RR 2 is H, A is methylene, B is methylene, R is hydrogen, R is 3,4- dimethoxyphenethyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 64. A compound of claim 1 of formula III and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is N, W is nitrogen, R . 15 i ■ s hydrogen or Me, R is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclopentyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is N, W is S, R is Me, R is Me, R is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is tetrahydropyranyl ; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is CH, W is S, R is Me, R is Me, R is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 65. A compound of claim 1 of formula IV and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is 3,4-dimethoxyphenethyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclopentyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula IV wherein X is N, R is Me, R is Me, R is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, RR 22 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin 2-yl-piperidin-4-yl. 66. A compound of claim 1 of formula V and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, is cyclohexyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R is 2,4,6-trimethylphenyl, is tetrahydropyranyl; a compound of formula V wherein X is CH, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 67. A compound of claim 1 of formula VI and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VI wherein X is CH, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R 6 i ■ s 3,4-dimethoxyphenethyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VI wherein X is N, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, is 3,4-dimethoxyphenethyl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 68. A compound of claim 1 of formula VII and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- ttrriimmeetthhyyllpphheennyyll,, P R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, I R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4 mmeetthhooxxyypphheennyyll,, RR 22 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 69. A compound of claim 1 of formula VIII and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula VIII wherein X is N, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VIII wherein X is CH, R is Me, R is Me, R is 2,6-dichloro-4- methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R 6 i • s cyclohexyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, RR 22 i is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4 dimethoxyphenethy 1 ; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 70. A compound of claim 1 of formula IX and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is cyclohexyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R is hydrogen, R is tetrahydropyranyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1 l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R is hydrogen, R is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R > 2 i ■ s H, A is methylene, B is methylene, R is hydrogen, R is cyclopentyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IX wherein X is CH, R 1 is Me, , R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula LX wherein X is N, R is Me, R is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R 5 i ■ s hydrogen, R is cyclopentyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl. 71. A compound of claim 1 of formula X and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula X wherein X is CH, R .1 : i,s Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula X herein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula X wherein X is CH, R 1 is Me, R is Me, R is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is cyclohexyl; a compound of formula X wherein X is CH, R is Me, R is Me, R is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is 1-pyrimidin- 2-yl-piperidin-4-yl ; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is tetrahydropyranyl ; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 72. A compound of claim 1 of formula XI and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- ttririmmeetthhyyllpphheennyyll,, RR 22 : is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4 dimethoxyphenethy 1 ; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is cyclopentyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, R R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XI wherein X is N, R is Me, R , 15 is Me, R is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is 1-pyrimidin- 2-yl-piperidin-4-yl. 73. A compound of claim 1 of formula XII and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is tetrahydropyranyl ; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me e, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- ttrriimmeetthhyyllpphheennyyll,, E R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1 -pyrimidin- 2-yl-piperidin-4-yl ; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclohexyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is 3 ,4-dimethoxyphenethyl; a compound of formula XII wherein X is CH, R is Me, R > 3 is H, R is Me, R is 2,6- dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is 1- 1 -pyrimidin-2-yl-piperidin-4-yl; a compound of formula XII wherein X is N, R is Me, R is H, R 16 is Me, R is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl. 74. A compound of claim 1 of formula XIII and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethy 1 ; a compound of formula XIII wherein X is CH, W is methylene, R is Me, R is H, R is Me e, R R 44 iiss 22,,44,,66--ttririmmeetthhyyllpphheennyyll,, RR 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; a compound of formula XIII wherein X is N, W is methylene, R is Me, R is H, R is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, RR 44 iiss 22,,66--ddiicchhlloorroo--44--mmeettlhoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIII wherein X is N, W is methylene, R is Me, R is H, R 16 is Me, R ι4 ; is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R >6 i • s cyclopentyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R l 44 i is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl. 75. A compound of claim 1 of formula XIV consisting and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group of: a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R R 44 iiss 22,,44,,66--ttrriimmeetthhyyllpphheenn;yl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is 3 ,4-dimethoxyphenethyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R R 44 iiss 22,,44,,66--ttirimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XIV wherein X is CH, R' is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, RR 44 iiss 22,,66--ddiicchhlloorroo--44--mmeetthhooxxyypphheennyyll,, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl a compound of formula XIV wherein X is N, R' is Me, -I=J-K=L- is -CH=CH-C(Me)=C RR 44 iiss 22,,66--ddiicchhlloorrco-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen R 6 is cyclopentyl a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XTV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIV wherein X is N, R 1 is Me-I=J-K=L- is -CH=CH-C(Me)=C-, R 4 iiss 22,,66--ddiicchhlloorroo--44--mmeetthhooxxyypplhenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R R 4 iiss 22,,66--ddiicchhlloorroo--44--mmeetthhooxxyypphheennyyll,, 1 R is H, A is methylene, B is methylene, R is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R iiss 22,,44,,66--ttrriimmeetthhyyllpphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R iiss 22,,44,,66--ttririmmeetthhyyllpphheennyyll,, is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R 5 is hydrogen, R is tetrahydropyranyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1 -pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclopentyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R is 22,,66--ddiicchhlloorroo-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2 2,,66--ddiicchhlloorroo--44--mmee1thoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XIV wherein X is N, R 1 is Me-I=J-K=L- -CH=CH-CH=C-, R is 2 2,,66--ddiicchhlloorroo--44--mmeetthhooxxyypplhenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethy 1 ; a compound of formula XIV wherein X is N, R l is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is 1 -pyrimidin-2-yl-piperidin-4-yl. 76. A compound of claim 1 of formula XV and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is cyclopentyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; 1 ^ a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R is Me, R is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; 1 ^ a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R is Me, R is Me, R R 4 iiss 22,,44,,66--ttrimethylphenyl, R >2 : is H, A is methylene, B is methylene, R is hydrogen, R is cyclopentyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R . 1 is. Me, R is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is cyclohexyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, RR 44 iiss 22,,44,,66--ttririmmeetthh:ylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R is Me, R R 44 iiss 22,,44,,66--ttririmmeetthhyyllpphheemnyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R is Me, R is Me, R R 44 iiss 22,,44,,66--ttririmmeetthhyyllpphheennyyll,, RR 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is pyrimidin-2-yl-piperidin-4-yl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R is Me, τ R> 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, RR 44 iiss 22,,66--ddiicchhlloorroo-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R is Me, R is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is tetrahydropyranyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R is Me, R is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl. 77. A method of modulating an NPY receptor by use as a compound of claim 1 of formula I and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of : a compound of formula I wherein X is CH or N, R 1 is methyl, R 2 is H, E is CH, F is CH, G is CH, R 4 is 2,4,6-trimethylphenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-cyclopentyl; 1 • a compound of formula I wherein X is CH or N, R is methyl, R is H, E is CH, F is CH, G is CH, R 4 is 2,6-dichlorophenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-cyclopentyl; a compound of formula I wherein X is CH or N, R 1 is methyl, R 2 is H, E is CH, F is CH, G is CH, R 4 is 2,4,6-trimethylphenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(tetrahydropyran-4-yl); 1 9 a compound of formula I wherein X is CH or N, R is methyl, R is H, E is CH, F is CH, G is CH, R 4 is 2,6-dichlorophenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(tetrahydropyran-4-yl); a compound of formula I wherein X is CH or N, R is methyl, R is H, E is CH, F is CH, G is CH, R 4 is 2,4,6-trimethylphenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(l-(pyrimidin-2-yl)-piperidin- 4-yl); 1 9 a compound of formula I wherein X is CH or N, R is methyl, R is H, E is CH, F is CH, G is CH, R 4 is 2,6-dichlorophenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(l-(pyrimidm-2-yl)-piperidin-4- yi); 1 9 a compound of formula I wherein X is CH or N, R is methyl, R is H, E is CH, F is CH, G is CH, R 4 is 2,4,6-trimethylphenyl, A-B-N[R 6 ]-R 5 is (CH 2 ) 2 -NH-(CH 2 ) 2 -(3 ,4-dimethoxyphenyl). 78. A method of modulating an NPY receptor by use of a compound of claim 1 of formula II and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula II wherein X is CH, R l is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me e, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula II wherein X is N, R is Me, R is H, R is Me, R is 2,4,6 ttririmmeetthhyyllpphheennyyll,, is 3,4- dimethoxyphenethyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula II wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula II wherein X is N, R 1 : i„s Λ M*e„, r R.3 i -s x Hj, R D 16 i ■ s Λ MΓe„, r R>4 i ■ s 2,6-dichloro-4 methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula II wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 79. A method of modulating an NPY receptor by use of a compound of claim 1 of formula III and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R R 33 iiss MMee,, RR 44 iiss 22,,44,,66--ttrriimmeetthhyyllpphheennyyll,, RR 22 iiss 1 H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula III wherein X is CH, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-rnethoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula III wherein X is N, W is nitrogen, R 15 is hydrogen or Me, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is 1-pyrimidin- 2-yl-ρiperidin-4-yl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is cyclopentyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula III wherein X is CH, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, RR 2 ι is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4 dimethoxyphenethyl; a compound of formula III wherein X is N, W is S, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 80. A method of modulating an NPY receptor by use of a compound of claim 1 of formula IV and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, is cyclopentyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IV wherein X is CH, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IV wherein X is CH, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, I R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula IV wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IV wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, R R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula IV wherein X is N, R is Me, R is Me, R is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, RR 22 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula IV wherein X is N, R is Me, R is Me, R is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 81. A method of modulating an NPY receptor by use of a compound of claim 1 of formula V and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is tetrahydropyranyl ; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula V wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclohexyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, RR 2 i is H, A is methylene, B is methylene, R is hydrogen, R is 3,4 dimethoxyphenethy 1 ; a compound of formula V wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- 9 S f mmeetthhooxxyypphheennyyll,, RR is H, A is methylene, B is methylene, R is hydrogen, R is 1-pyrimidin- 2-yl-piperidin-4-yl. 82. A method of modulating an NPY receptor by use of a compound of claim 1 of formula VI and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VI wherein X is N, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R° is tetrahydropyranyl; a compound of formula VI wherein X is N, R 1 is Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is tetrahydropyranyl; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula VI wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VI wherein X is N, R 1 is Me, R is Me, R is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VI wherein X is N, R is Me, R is Me, R is 2,6-dichloro-4 mmeetthhooxxyypphheennyyll,, I R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VI wherein X is N, R l is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula VI wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 83. A method of modulating an NPY receptor by use of a compound of claim 1 of formula VII and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclopentyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, is tetrahydropyranyl ; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclohexyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VII wherein X is CH, R 1 is Me, R 1 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VII wherein X is CH, R is Me, R is Me, R is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, RR 22 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is tetrahydropyranyl ; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 84. A method of modulating an NPY receptor by use of a compound of claim 1 of formula VIII and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, is cyclohexyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- ttrriimmeetthhyyllpphheennyyll,, F R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- ttririmmeetthhyyllpphheennyyll,, RR 22 : is H, A is methylene, B is methylene, R 5 is hydrogen, R° is 3,4- dimethoxyphenethyl ; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R ,2 is H, A is methylene, B is methylene, R is hydrogen, R is cyclopentyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VIII wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl ; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula VIII wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 85. A method of modulating an NPY receptor by use of a the compound of claim 1 of formula IX and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IX wherein X is CH, R 1 is Me, R is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1 l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IX wherein X is N, R is Me, R is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IX wherein X is CH, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IX wherein X is CH, R 1 is Me, , R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IX wherein X is CH, R 1 is Me, R is 2,6-dichloro-4-methoxyphenyl, R R 22 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula IX wherein X is N, R 1 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yl. 86. A method of modulating an NPY receptor by use of a compound of claim 1 of formula X and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclohexyl; a compound of formula X wherein X is N, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl a compound of formula X wherein X is N, R is Me, R is Me, R is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R 6 i •s 3,4-dimethoxyphenethyl a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is l-pyrimidin-2-yl-ρiperidin-4- yi a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R 6 i • s cyclohexyl; a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl a compound of formula X wherein X is CH, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula X wherein X is CH, R is Me, R is Me, R is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, RR 22 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl ; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula X wherein X is N, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1 -pyrimidin- 2-yl-piperidin-4-yl . 87. A method of modulating an NPY receptor by use of a compound of claim 1 of formula XI and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is tetrahydropyranyl ; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is 3,4- dimethoxyphenethyl ; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XI wherein X is N, R is Me, R 15 is Me, R is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4- yi; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- mmeetthhooxxyypphheennyyll,, R R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula XI wherein X is CH, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XI wherein X is N, R 1 is Me, R 15 is Me, R 4 is 2,6-dichloro-4 mmeetthhooxxyypphheennyyll,, RR 22 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl a compound of formula XI wherein X is N, R 1 is Me, R is Me, R is 2,6-dichloro-4- methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl. 88. A method of modulating an NPY receptor by use of a compound of claim 1 of formula XII and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl;; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl;; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me e, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XII wherein X is N, R is Me, R is H, R 16 is Me, R is 2,4,6 trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl;; a compound of formula XII wherein X is N, R is Me, R is H, R is Me, R is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XII wherein X is N, R is Me, R • 3 i • s T HT, τ R> 16 is Me, R is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6- trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1-pyrimidin- 2-yl-piperidin-4-yl ; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, is cyclopentyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; a compound of formula XII wherein X is CH, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6- dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- 1 -pyrimidin-2-yl-piperidin-4-yl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro- 4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro 4 4--mmeetthhooxxyypphheennyyll,, R is H, A is methylene, B is methylene, R is hydrogen, R i: tetrahydropyranyl a compound of formula XII wherein X is N, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro 4 4--mmeetthhooxxyypphheennyyll,, E R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl a compound of formula XII wherein X is N, R is Me, R is H, R , 16 is Me, R is 2,6-dichloro- 4-methoxyphenyl, is 1- pyrimidin-2-yl-piperidin-4-yl. 89. A method of modulating an NPY receptor by use of a compound of claim 1 of formula XIII and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula XIII wherein X is CH, W is methylene, R is Me, R is H, R is Me, RR 44 iiss 22,,44,,66--ttrrimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R R 44 iiss 22,,44,,66--ttririmmeetthhylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl ; a compound of formula XIII wherein X is CH, W is methylene, R is Me, R is H, R is Me e, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1 -pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl ; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a confound of formula XIII wherein X is CH, W is methylene, R is Me, R is H, R is Me, R is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R 5 i ■ s hydrogen, R 6 is cyclohexyl; a compound of formula XIII wherein X is CH, W is methylene, R is Me, R is H, R is Me, R >4 i • s 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIII wherein X is CH, W is methylene, R is Me, R is H, R is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XIII wherein X is CH, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 1 -pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIII wherein X is N, W is methylene, R 1 is Me, R 3 is H, R 16 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XIII wherein X is N, W is methylene, R is Me, R is H, R 1 is Me, R is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R 5 i ■ s hydrogen, R is l-pyrimidin-2-yl-piperidin-4-yl. 90. A method of modulating an NPY receptor by use of a compound of claim 1 of formula XIV consisting and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group of: a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C R R 44 iiss 22,,44,,66--ttιrimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, RR 44 iiss 22,,66--ddiicchhlloorrco-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIV wherein X is N, R 1 is Me-I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is 3,4-dimethoxyphenethyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-C(Me)=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 9 ^ f is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is cyclopentyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R ' iiss 22,,44,,66--ttririmmeetthhyyllpphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl ; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R is H, A is methylene, B is methylene, R is hydrogen, R is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4- dimethoxyphenethyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is tetrahydropyranyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is 3,4-dimethoxyphenethyl; a compound of formula XIV wherein X is CH, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R iiss 22,,66--ddiicchhlloorroo--44--mmeetthhooxxyypphheennyyll,, ] R is H, A is methylene, B is methylene, R is hydrogen, R is 1 -pyrimidin-2-yl-piperidin-4-yl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XIV wherein X is N, R 1 is Me-I=J-K=L- -CH=CH-CH=C-, R 4 is 2 2,,66--ddiicchhlloorroo--44--mmeetthhooxxyypplhenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; a compound of formula XIV wherein X is N, R 1 is Me, -I=J-K=L- is -CH=CH-CH=C-, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1 -pyrimidin-2-yl-piperidin-4-yl. 91. A method of modulating an NPY receptor by use of a compound of claim 1 of formula XV and isomers thereof, stereoisomeric forms thereof, or mixture of stereoisomeric forms thereof, and pharmaceutically acceptable salt or prodrug forms thereof, selected from the group consisting of: a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl ; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R R 44 iiss 22,,44,,66--ttrriimmeetthhyyllpphheennyyll,, R E 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R ι 3 J i • s Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R R 44 iiss 22,,44,,66--trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl ; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,4,6-trimethylphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3 ,4-dimethoxyphenethyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R is Me, R is Me, R R 44 iiss 22,,44,,66--ttrriimmeetthhyyllpphheennyyll,, RR 22 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 1- pyrimidin-2-yl-piperidin-4-yl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is cyclopentyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is tetrahydropyranyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R is Me, R is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R is 3,4-dimethoxyphenethyl; a compound of formula XV wherein X is CH, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R is 2,6-dichloro-4-methoxyphenyl, R is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclopentyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is cyclohexyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R > is tetrahydropyranyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is 3,4-dimethoxyphenethyl; a compound of formula XV wherein X is N, Y is carbon, Q is oxygen, R 1 is Me, R 3 is Me, R 4 is 2,6-dichloro-4-methoxyphenyl, R 2 is H, A is methylene, B is methylene, R 5 is hydrogen, R 6 is l-pyrimidin-2-yl-piperidin-4-yl.

Inventors: CARPINO PHILIP A, DE LOMBAERT STEPHANE, GRIFFITH DAVID A, HODGETTS KEVIN JULIAN, HORVATH RAYMOND F, TRAN JENNIFER, CARPINO, PHILIP, A., DE LOMBAERT, STEPHANE, GRIFFITH, DAVID, A., HODGETTS, KEVIN, JULIAN, HORVATH, RAYMOND, F., TRAN, JENNIFER
Applicants: CARPINO PHILIP A, GRIFFITH DAVID A, HODGETTS KEVIN JULIAN, HORVATH RAYMOND F, LOMBAERT STEPHANE DE, NEUROGEN CORP, PFIZER, TRAN JENNIFER, CARPINO, PHILIP, A., DE LOMBAERT, STEPHANE, GRIFFITH, DAVID, A., HODGETTS, KEVIN, JULIAN, HORVATH, RAYMOND, F., NEUROGEN CORPORATION, PFIZER, INC., TRAN, JENNIFER
Application year: 2000
Main classification: C07D487
IPC codes: A61K31, A61P1, A61P3, A61P5, A61P7, A61P9, A61P11, A61P13, A61P15, A61P25, A61P29, A61P43, C07D213, C07D215, C07D239, C07D471, C07D473, C07D475, C07D487, C07D495