INHIBITION OF POLYMERIZATION OF UNSATURATED MONOMERS

Abstract: Disclosed herein is a method for inhibiting the premature polymerization of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of a mixture comprising: A) at least one stable hindered nitroxyl compound having structural formula (I) wherein R>1< and R>4< are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substituted alkyl and R>2< and R>3< are independently selected from the group consisting of alkyl and heteroatom-substituted alkyl; and X>1< and X>2< (1) are independently selected from the group consisting of halogen, cyano, COOR>7<, -S-COR>7<, -OCOR>7<, (wherein R>7< is alkyl or aryl), amido, -S-C>6<H>5<, carbonyl, alkenyl, or alkyl of 1 to 15 carbon atoms, or (2) taken together, form a ring structure with the nitrogen; and B) at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para-hydroquinone, and derivatives of the foregoing.

Description: INHIBITION OF POLYMERIZATION OF UNSATURATED MONOMERS BACKGROUND OF THE INVENTION 5 1. Field of the Invention The present invention is directed to the use of a combination of at least one stable nitroxide free radical compound and at least one quinone and/or hydroquinone o (hereinafter, quinone/hydroquinone) to inhibit the polymerization of ethylenically unsaturated monomers. 2. Description of Related Art Many ethylenically unsaturated monomers undesirably polymerize at various stages of their manufacture, processing, handling, storage, and use. A particularly s troublesome problem is equipment fouling caused by polymerization in the purification stages of the production processes of such monomers. Polymerization, such as thermal polymerization, during their purification results in the loss of the monomer and a loss in production efficiency owing to the deposition of polymer in or on the equipment being used in the purification, the deposits of which must be o removed from time to time. Additionally, the formation of soluble polymer leads to loss of monomer, i.e., a lower yield, and an increase in the viscosity of any tars that may be produced. The processing of the tars then requires higher temperature and work (energy cost) to remove residual monomer. A wide variety of compounds has been proposed and used for inhibiting 5 uncontrolled and undesired polymerization of ethylenically unsaturated monomers. However, these compounds have not been fully satisfactory. Accordingly, there has been a substantial need in the art for improved compositions for inhibiting the polymerization of such monomers during their production and the distillation process for purifying or separating them from impurities, as well as during transport and storage. Hindered nitroxyl compounds are known to be very active inhibitors of free radical polymerizations of unsaturated monomers such as styrene, acrylic acid, methacrylic acid, and the like. Quinones and hydroquinones are also known to have a similar capacity. Wang et al, Lanzhou Daxue Xuebao, Ziran Kexueban 25(3,): 138- 140 (1987) evaluated the inhibition effect of the stable nitroxide free radical, di-t-butylnitroxide, on the polymerization of acrylic acid and styrene monomers by three methods: separation method, reboiling method, and expanding method. The results showed that di-t-butylnitroxide itself has an inhibiting effect, and when it blends with hydroquinone, t-butyl catechol, benzoquinone, the inhibition effect is better than common inhibitors. U.S. Patent Number 3,163,677 discloses N,N,O-trisubstituted hydroxylamines and N,N-disubstituted nitroxides of the formulae: - -N— O* wherein R l 5 R 2 , and R 3 are each an alkyl radical having 1 to 15 carbon atoms. (As used herein, the designation N-O* denotes a stable free radical wherein the asterisk is an unpaired electron.) The N,N,O-trisubstituted hydroxylamines can be used to make the N,N-disubstituted nitroxides, which are stable free radicals and are said to be useful as polymerization inhibitors. U.S. Patent Number 3,334,103 discloses that nitroxides can be prepared from the corresponding heterocyclic amine wherein the nitrogen atom of the nitroxide 5 group is attached to other than a tertiary carbon of an aliphatic group (i.e. , the nitrogen atom forms a part of a heterocyclic nucleus). These nitroxides are said to have useful properties similar to those described for the N,N-disubstituted nitroxides of U.S. Patent Number 3, 163,677. U.S. Patent Number 3,372,182 discloses that a great variety of N,N- o disubstitated, stable, free radical nitroxides not otherwise readily available can be prepared by a simple and convenient process that comprises pyrolyzing in an inert reaction medium virtually any hydroxylamine that is susceptible to cleavage of the O- C bond, e.g., tri-t-butylhydroxylamine. U.K. Patent Number 1,127,127 discloses that acrylic acid can be stabilized s against polymerization by the addition thereto of a nitroxide having the essential skeletal structure: o wherein R j , R 2 , R 3 , and R 4 are alkyl groups and no hydrogen is bound to the remaining valencies on the carbon atoms bound to the nitrogen. The two remaining valencies that are not satisfied by R, to R 4 or nitrogen can also form part of a ring (e.g. , 2,2,6,6 tetramethyl-4-hydroxy-piperidine-l-oxyl). U.S. Patent Number 3,422,144 discloses stable, free radical nitroxides of the formula: o* H I R^ I ^N^ C R 1 I R 5 wherein R is selected from the group consisting of tertiary alkyl, aryl, alkaryl, haloaryl, carboxyaryl, alkoxyaryl, alkylthioaryl, pyridyl, and dialkylaminoaryl, and R' is tertiary alkyl. These nitroxides are said to be useful as traps for reactive free radicals both in the counting of free radicals and for inhibiting oxidation and free o radical polymerization. U.S. Patent Number 3,494,930 discloses free radicals of the nitroxide type for use as initiators of free radical reactions, collectors of free radicals, polymerization inhibitors or antioxidants. They are constituted by nitrogenous bicyclic compounds in which one of the bridges comprises solely the nitroxide radical group and, in s particular, by aza-9-bicyclo (3,3,1) nonanone-3-oxyl-9, and by aza-9-bicyclo (3,3,1) nonane oxyl-9. U.S. Patent Number 3,873,564 discloses compounds and a method for assaying enzymes by adding to a medium containing an enzyme a stable free radical compound having a stable free radical functionality which, when subjected to an o enzyme-catalyzed reaction, changes the environment of the free radical functionality. By following the change in the electron spin resonance spectrum as affected by the change in environment, the type of enzyme and the activity of the enzyme can be determined. The compounds found useful are normally stable nitroxide radicals with an enzyme labile functionality. Other compounds include two cyclic nitroxide containing rings joined by a chain having an enzyme labile functionality. U.S. Patent Number 3,966,711 teaches that 2,2,7,7-tetraalkyl- and 2,7- dispiroalkylene-5-oxo-l,4-diazacycloheptanes substituted in the 4-position by mono- or tetravalent radicals are powerful light-stabilizers for organic polymers. They are said to possess higher compatibility than their 4-unsubstituted homologues, from which they can be synthesized by reactions known for N-alkylation. Preferred substituents in the 4-position are alkyl, alkylene, alkenyl, aralkyl, and esteralkyl groups. The 1-nitroxyls derived from the imidazolidines by oxidation with hydrogen peroxide or percarboxylic acids are also said to be good light stabilizers. U.S. Patent Number 4,182,658 discloses a method for preventing the polymerization of a readily polymerizable vinyl aromatic compound during distillation at elevated temperatures within a distillation apparatus that is subject to an emergency condition, such as a power outage. This method comprises force-feeding a supplemental polymerization inhibitor having a high solubility in the vinyl aromatic compound and a long duration of efficiency into each of the distillation vessels of a conventional distillation apparatus in an amount sufficient to prevent polymerization therein. European Patent Application 0 178 168 A2 discloses a method for inhibiting the polymerization of an ,β-ethylenically unsaturated monocarboxylic acid during its recovery by distillation by using a nitroxide free radical. U.S. Patent Number 4,665,185 discloses a process for the efficient preparation of nitroxyls of sterically hindered amines by the oxidation of the amine using a hydroperoxide in the presence of a small amount of a metal ion catalyst, at moderate temperature for a short period of time, to give the nitroxyl in high yield and purity. U.S. Patent Number 5,254,760 teaches that the polymerization of a vinyl aromatic compound, such as styrene, is very effectively inhibited during distillation or purification by the presence of at least one stable nitroxyl compound together with at least one aromatic nitro compound. U.S. Patent Numbers 5,545,782 and 5,545,786 disclose that nitroxyl inhibitors in combination with some oxygen reduce the premature polymerization of vinyl aromatic monomers during the manufacturing processes for such monomers. Even small quantities of air used in combination with the nitroxyl inhibitors are said to result in vastly prolonged inhibition times for the monomers. European Patent Application 0 765 856 Al discloses a stabilized acrylic acid composition in which the polymerization of the acrylic acid is inhibited during the distillation process for purifying or separating the acrylic acid as well as during transport and storage. The compositions comprise three components: (a) acrylic acid, (b) a stable nitroxyl radical, and (c) a dihetero-substituted benzene compound having at least one transferable hydrogen (e.g. , a quinone derivative such as the monomethyl ether of hydroquinone (MEHQJ). During the distillation process, transport, and storage, components (b) and (c) are present in a polymerization- inhibiting amount. During the distillation process, oxygen (d) is preferably added with components (b) and (c). According to the specification, examples of suitable nitroxide free radical compounds include di-t-butylnitroxide; di-t-amylnitroxide; 2,2,6 , 6-tetramethy 1-piperidinyloxy ; 4-hydroxy-2 ,2,6, 6-tetramethyl-piperidiny loxy ; 4-oxo-2 ,2,6, 6-tetramethy 1-piperidiny loxy ; 4-dimethy lamino-2 ,2,6.6-tetramefhy 1- piperidiny loxy ; 4-amino-2 ,2,6, 6-tetramethy 1-piperidinyloxy ; 4-ethanoy loxy-2 ,2,6,6- tetramethy 1-piperidiny loxy ; 2,2,5,5 -tetramethy lpyrrolidiny loxy ; 3 -amino-2 ,2,5,5- tetramethy lpyrrolidiny loxy : 2,2,5,5 -tetramethy 1- 1 -oxa-3 -azacyclopentyl-3 -oxy ; 2,2,5,5-tetramethyl-l-oxa-3-pyrrolinyl-l-oxy-3-carboxylic acid; and 2,2,3,3,5,5,6,6- octamethyl-1 ,4-diazacyclohexyl-l ,4-dioxy . WO 97/46504 concerns substance mixtures containing: (A) monomers containing vinyl groups; and (B) an active amount of a mixture which inhibits premature polymerization of the monomers containing vinyl groups during their purification or distillation and contains: (i) between 0.05 and 4.5 wt % , relative to the total mixture (B), of at least one N-oxyl compound of a secondary amine which has no hydrogen atom at the -C atoms: and (ii) between 99.95 and 95.5 wt % relative to the total mixture (B), of at least one nitro compound. The publication also discloses a process for inhibiting the premature polymerization of monomers, and the use of mixture (B) for inhibiting the premature polymerizatin of monomers . WO 98/02403 relates to inhibiting the polymerization of vinyl aromatic compounds by using a mixture of a phenol and a hydroxylamine. It is said that the process is useful in ethylbenzene dehydrogenation effluent condenser systems and styrene-water separator vent gas compressor systems and that it effectively inhibits polymerization of monomers, preventing the formation of a polymer coating on condenser and compressor equipment, thus reducing the necessity for cleaning of equipment surfaces. WO 98/14416 discloses that the polymerization of vinyl aromatic monomers such as styrene is inhibited by the addition of a composition of a stable hindered nitroxyl radical and an oxime compound. WO 98/25872 concerns substance mixtures containing: (A) compounds containing vinyl groups; (B) an active amount of a mixture which inhibits premature polymerization of the compounds containing vinyl groups and contains: (i) at least one N-oxyl compound of a secondary amine which does not carry any hydrogen atoms on the α-carbon atoms; and (ii) at least one iron compound; (C) optionally nitro compounds; and (D) optionally co-stabilizers. The publication also discloses a process for inhibiting the premature polymerization of compounds (A) containing vinyl groups, and the use of (B) optionally mixed with nitro compounds (C) and/or co-stabilizers (D) for inhibiting the premature polymerization of radically polymerizable compounds and stabilizing organic materials against the harmful effect of radicals. CS-260755 Bl is directed to the preparation of 4-substitated-2, 2,6,6- tetramethylpiperidine nitroxyls as olefin stabilizers. SU-334845 Al is directed to the inhibition of the radical polymerization of oligoester acrylates using iminoxyl radical inhibitors of a given formula. SU-478838 is directed to the inhibition of the radical polymerization of oligoester acrylates and the prevention of oligomeric peroxides using a binary polymerization inhibitor comprising quinone. FR 2,761,060 relates to the prevention of premature polymerization of styrene during its production by dehydrogenation of ethylbenzene by injecting into the process effluent a radical inhibitor based on an oxyl-tetramethylpiperidine derivative. The foregoing are incorporated herein by reference in their entirety. SUMMARY OF THE INVENTION As used herein, the abbreviation TEMPO stands for 2,2,6,6-tetramethyl-l- piperidinyloxy. Thus, 4-amino-TEMPO is 4-amino-2, 2, 6, 6-tetramethy 1-1 - piperidinyloxy; 4-hydroxy-TEMPO is 4-hydroxy-2,2,6,6-tetramethyl-l- piperidinyloxy (also known in the art as HTEMPO); 4-oxo-TEMPO is 4-oxo-2,2,6,6- tetramethyl-1 -piperidinyloxy; and so on. As mentioned above, (a) hindered nitroxyl compounds and (b) quinones and/or hydroquinones are each separately known to be very active inhibitors of free radical polymerizations of unsaturated monomers. The present invention is directed to the discovery that a mixture of at least one stable hindered nitroxyl compound (e.g. , 4- amino-TEMPO or 4-oxo-TEMPO) with at least one quinone/hydroquinone provides better performance than either component alone, as indicated by the slow rate of polymerization after shutoff of feed in a steady state dynamic testing system. More particularly, the present invention is directed to a method for inhibiting the premature polymerization of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of a mixture comprising: A) at least one inhibitor having the following structural formula: | 1 | 2 R 1 I ^ N ' 4 (I) R I R 2 ' 3 0* and B) at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para-hydroquinone, and derivatives of the foregoing. In formula (I), Rj and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl; and X { and X 2 (1) are independently selected from the group consisting of halogen, cyano, COOR 7 , -S-COR 7 , -OCOR 7 , (wherein R 7 is alkyl or aryl), amido, -S-C 6 H 5 , carbonyl, alkenyl, or alkyl of 1 to 15 carbon atoms, or (2) taken together, form a ring structure with the nitrogen, preferably of five, six, or seven members. The present invention is directed preferably to a method for inhibiting the premature polymerization of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of a mixture comprising: A) at least one inhibitor having the structural formula: wherein R j and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl, and the portion represents the atoms necessary to form a five-, six-, or seven-membered heterocyclic ring and B) at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para-hydroquinone, and derivatives of the foregoing. The atoms necessary to complete the ring referred to above are preferably carbon atoms, but heteroatoms, such as O, N, P, or S, may also be present. The effective amount of the combination of nitroxyl compound and quinone/hydroquinone is typically about 1 to 2,000 ppm, based on the weight of the ethylenically unsaturated monomer, although amounts outside this range may be appropriate depending upon the conditions of use. The amount of the combination of nitroxyl compound and quinone/hydroquinone is preferably about 5 to about 1,000 ppm, based on the weight of the ethylenically unsaturated monomer. In another embodiment, the present invention is directed to a composition comprising: (a) an ethylenically unsaturated monomer, and (b) an effective inhibiting amount, to prevent premature polymerization of the ethylenically unsaturated monomer, of a mixture of i) at least one inhibitor having the structural formula: X X I 2 R - C , - C -R i I N I ι (I) R R o* and ii) at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para-hydroquinone, and derivatives of the foregoing. In formula (I), R j and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl; and X j and X 2 (1) are independently selected from the group consisting of halogen, cyano, COOR 7 , -S-COR 7 , -OCOR 7 , (wherein R 7 is alkyl or aryl), amido, -S-C 6 H 5 , carbonyl, alkenyl, or alkyl of 1 to 15 carbon atoms, or (2) taken together, form a ring structare with the nitrogen, preferably of five, six, or seven members. In a preferred embodiment, the present invention is directed to a composition comprising: (a) an ethylenically unsaturated monomer, and (b) an effective inhibiting amount, to prevent premature polymerization of the ethylenically unsaturated monomer, of a mixture of (i) 1 to 99 percent by weight, based on the total weight of components (i) and (ii), of at least one inhibitor having the structural formula: x I 1 • C^ / C-R N N I (I) I R 3 o W * and, correspondingly, (ii) 99 to 1 percent by weight of at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para- hydroquinone, and derivatives of the foregoing, wherein R l 5 R 2 , R 3 , R 4 , X, and X 2 are as described above. The preferred amounts of components (i) and (ii) are 10 to 90 percent by weight of component (i) and, correspondingly, 90 to 10 percent by weight of component (ii); more preferably, 20 to 80 percent by weight of component (i) and, correspondingly, 80 to 20 percent by weight of component (ii); and most preferably, 20-50 percent by weight of component (i) and 50-80 percent by weight of component (ii). BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a graph showing polymer made during feed shut-off at 116° C. Prior to feed shut-off, these tests were run under dynamic conditions at 116° C for seven hours with a one hour residence time and containing 100 or 105 ppm total inhibitor. Figure 2 is a graph showing polymer made during feed shut-off at 116° C. Prior to feed shut-off, these tests were run under dynamic conditions at 116° C for seven hours with a one hour residence time and containing 150 ppm total inhibitor. DESCRIPTION OF THE PREFERRED EMBODIMENTS As stated above, in one preferred aspect, the present invention is directed to a method for inhibiting the premature polymerization of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of a mixture comprising: A) at least one inhibitor having the structural formula: wherein K and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl, and the portion represents the atoms necessary to form a five-, six-, or seven-membered heterocyclic ring; and B) at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para-hydroquinone, and derivatives of the foregoing. Accordingly, one of the several classes of cyclic nitroxides that can be employed in the practice of the present invention can be represented by the following structural formula: wherein Z,, Z 2 , and Z 3 are independently selected from the group consisting of oxygen, sulfur, secondary amines, tertiary amines, phosphorus of various oxidation states, and substituted or unsubstituted carbon atoms, such as >CH 2 . >CHCH 3 , >C=O, >C(CH 3 ) 2 , >CHBr, >CHC1, >CHI, >CHF, >CHOH. >CHCN, >C(OH)CN, >CHCOOH, >CHCOOCH 3 , >CHCOOC 2 H 5 , >C(OH)COOC 2 H 5 , >C(OH)COOCH 3 , >C(OH)CHOHC 2 H 5 , >CNR 5 R 6 _ >CCONR 5 R 6 . >CH = NOH, >C=CH-C 6 H 5 , >CF 2 , >CC1 2 , >CBr 2 , >CI 2 , >CPR 13 R 14 R 15 , and the like, where R 5 and R 6 are independently selected from the group consisting of hydrogen, alkyl, aryl, and acyl and R 13 R 14 and R 15 are independently selected from the group consisting of unshared electrons, alkyl, aryl, =O, OR 16 , and NR π R lg . where R 16 , R 17 and R lg are independently selected from the group consisting of hydrogen, alkyl, and aryl . Where R 5 and/or R 6 are alkyl, it is preferred that they be a lower alkyl (i.e., one having one to four carbon atoms, e.g., methyl, ethyl, propyl, butyl, and isomers thereof). Where R 5 and/or Rg are aryl, it is preferred that they be aryl of from 6 to 10 carbon atoms, e.g., phenyl or naphthyl, which, in addition, may be substituted with non-interfering substitaents, e.g., lower alkyl groups, halogens, and the like. Where R 5 and/or R 6 are acyl, it is preferred that they be acyl of the structure where R !9 is alkyl, aryl, OR 20 , or NR 20 R 21 and where R 20 and R 21 are alkyl, aryl, or where R 22 is alkyl or aryl. Where R 19 , R 20 , R 2J , or R 22 are alkyl, they are preferably alkyl of from 1 to 15 carbon atoms, more preferably lower alkyl of from 1 to 4 carbon atoms, as described above. Where R 19 , R 20 , R 21 , or R 22 are aryl, they are preferably aryl of from 6 to 10 carbon atoms, as described above. Another of the several classes of cyclic nitroxides that can be employed in the practice of the present invention can be represented by the following structural formula: wherein Z j and Z 2 , which may be the same or different, are nitrogen or substitated or unsubstitated carbon atoms, such as =C(H)-, =C(CH 3 )-, =C(COOH)-, =C(COOCH 3 )-, =C(COOC 2 H 5 )- =C(OH)-, =C(CN)-, =C(NR 5 R 6 )- = C(CONR 5 R 6 )-, and the like, and where Z 3 , R 5 , and R 6 are as described above. The cyclic nitroxides employed in the practice of the present invention can also be derived from five-membered rings. These compounds are of the structare: wherein Z 2 and Z 3 , which may be the same or different, are sulfur, oxygen, secondary amines, tertiary amines, phosphorus of various oxidation states, or substituted or unsubstitated carbon atoms, such as, >CH 2 , >CHCH 3 , >C = O, >C(CH 3 ) 2 , >CHBr, >CHC1, >CHI, >CHF, >CHOH, >CHCN, >C(OH)CN, >CHCOOH, >CHCOOCH 3 , >CHCOOC 2 H 5 , >C(OH)COOC 2 H 5 , >C(OH)COOCH 3 , >C(OH)CHOHC 2 H 5 , >CNR 5 R 6 >CCONR 5 R 6 , >CH = NOH, >C = CH-C 6 H 5 , CF 2 , CC1 2 , CBr 2 , CI 2 , >CPR 13 R 14 R 15 , and the like, wherein the several R groups are as described above. The cyclic nitroxides employed in the practice of the present invention can also have the structare: wherein Z 4 and Z 5 , which can be the same or different, can be nitrogen or a substituted or unsubstitated carbon atom, such as =C(H)-, =C(CH 3) _, =C(COOH)-, = C(COOCH 3 )-, =C(COOC 2 H 5 )- =C(OH)-, =C(CN)-, =C(NR 5 R 6 )- =C(CONR 5 R, 5 )-, and the like, where R 5 and R 6 are as described above. Another class of cyclic nitroxides that can be employed in the practice of the present invention is of the structare: wherein Z 2 and Z 3 , which may be the same or different, are sulfur, oxygen, secondary amines, tertiary amines, or substitated or unsubstitated carbon atoms, such as, > CH 2 , > CHCH 3 , > C = O, > C(CH 3 ) 2 , > CHBr, > CHC1, > CHI, > CHF, > CHOH, > CHCN, > C(OH)CN, > CHCOOH, > CHCOOCH 3 , > CHCOOC 2 H 5 , > C(OH)COOC 2 H 5 , > C(OH)COOCH 3 , > C(OH)CHOHC 2 H 5 , > CNR 5 R 6 > CCONR 5 R 6 , > CH=NOH, > C = CH-C 6 H 5 , CF 2 , CC1 2 , CBr 2 , Cl 2 , and the like, where R 5 and R 6 are as described above. Further, two or more nitroxyl groups can be present in the same molecule, for example, by being linked through one or more of the Z-type moieties by a linking group E, as disclosed in U.S. Patent Number 5,254,760, which is incorporated herein by reference. As stated above, R and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl. The alkyl (or heteroatom-substitated alkyl) groups R, through R 4 can be the same or different and preferably contain 1 to 15 carbon atoms, e.g. , methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, and the like, and isomers thereof, e.g., t-butyl, 2-ethylhexyl, and the like. It is more preferred that R through R 4 be independently selected lower alkyl (or heteroatom-substitated lower alkyl) of one to four carbon atoms (e.g.. methyl, ethyl, propyl, butyl, and isomers thereof). Where heteroatom substitaents are present, they can, for example, include halogen, oxygen, sulfur, nitrogen, and the like. It is most preferred that all of R j through R 4 be methyl. Examples of suitable nitroxide free radical compounds that can be used in combination with the quinone/hydroquinone inhibitor in the practice of the present invention, include, but are not limited to: 2, 2, 6, 6-tetramethy 1-piperidiny loxy; 4-amino-2 ,2,6, 6-tetramethy 1-piperidiny loxy ; 4-hydroxy-2 ,2,6, 6-tetramethy 1-piperidinyloxy ; -oxo-2 ,2,6, 6-tetramethy 1-piperidinyloxy ; -dimethy lamino-2 ,2,6, 6-tetramethy 1-piperidinyloxy ; -ethanoyloxy-2 ,2 ,6 ,6-tetramethyl-piperidinyloxy ; ,2,5 ,5-tetramethylpyrrolidinyloxy; -amino-2,2,5,5-tetramethylpyrrolidinyloxy; ,2,4, 4-tetramethy 1- 1 -oxa-3 -azacy clopenty 1-3 -oxy ; ,2,4,4-tetramethyl-l-oxa-3-pyrrolinyl-l-oxy-3-carboxylic acid; ,2,3,3,5,5,6,6-octamethyl-l,4-diazacyclohexyl-l,4-dioxy; -bromo-2 ,2,6, 6-tetramethy 1-piperidiny loxy ; -chloro-2 ,2 , 6 , 6-tetramethy 1-piperidiny loxy ; -iodo-2 ,2,6, 6-tetramethy 1-piperidiny loxy ; -fluoro-2 ,2,6, 6-tetramethy 1-piperidiny loxy ; -cy ano-2 ,2,6 , 6-tetramethy 1-piperidiny loxy ; -carboxy-2 ,2,6, 6-tetramethy 1-piperidinyloxy ; -carbomethoxy-2 ,2 , 6 , 6-tetramethyl-piperidiny loxy ; -carbethoxy-2 ,2,6 , 6-tetramethy 1-piperidinyloxy ; -cyano-4-hydroxy-2 ,2,6 , 6-tetramethy 1-piperidiny loxy ; -methyl-2, 2, 6, 6-tetramethy 1-piperidinyloxy; -carbethoxy-4-hy droxy-2 ,2,6, 6-tetramethy 1-piperidiny loxy ; -hydroxy-4-( 1 -hydroxypropyl)-2 ,2,6, 6-tetramethyl-piperidiny loxy ; -methy 1-2 ,2,6, 6-tetramethyl- 1,2,5, 6-tetrahydropyridine - 1 -oxyl ; -carboxy-2 ,2,6, 6-tetramethyl- 1,2,5, 6-tetrahydropyridine - 1 -oxy 1 ; -carbomethoxy-2 ,2,6, 6-tetramethyl- 1,2,5, 6-tetrahydropyridine - 1 -oxyl ; -carbethoxy-2 ,2 , 6 , 6-tetramethy 1- 1,2,5 ,6-tetrahydropyridine - 1 -oxyl ; -amino-2 ,2,6 , 6-tetramethy 1- 1 ,2,5, 6-tetrahydropyridine - 1 -oxyl ; -amido-2 ,2,6 , 6-tetramethy 1- 1 ,2,5, 6-tetrahydropyridine - 1 -oxy 1 ; ,4-diketo-2,2,5,5-tetramethylpyrrolidinyloxy; -keto-4-oximino-2,2,5,5-tetramethylpyrrolidinyloxy; -keto-4-benzylidine-2 ,2,5,5 -tetramethy lpyrrolidinyloxy ; -keto-4,4-dibromo-2 ,2 , 5 , 5-tetramethy lpyrrolidiny loxy ; ,2,3,3,5,5-hexamethylpyrrolidinyloxy; -carboximido-2,2,5,5-tetramethylpyrrolidinyloxy; -oximino-2,2,5 ,5-tetramethylpyrrolidinyloxy ; -hy droxy-2 ,2,5,5 -tetramethy lpy rrolidiny loxy ; -cyano-3-hy droxy-2 ,2 , 5 , 5-tetramethy lpyrrolidinyloxy ; -carbomethoxy-3-hydroxy-2 ,2,5 , 5-tetramethy lpyrrolidinyloxy ; -carbethoxy-3 -hy droxy-2 ,2 , 5 , 5-tetramethy lpyrrolidiny loxy ; 2 ,2 ,5 ,5-tetramethyl-3-carboxamido-2 , 5-dihydropyrrole- 1 -oxyl ; 2,2 ,5 , 5-tetramethyl-3-amino-2 ,5-dihydropyrrole- 1 -oxyl ; 2,2,5 , 5-tetramethyl-3 -carbethoxy-2 , 5-dihydropyrrole- 1 -oxy 1 ; 2,2,5,5-tetramethyl-3-cyano-2,5-dihydropyrrole-l-oxyl; bis( 1 -oxy 1-2 ,2 , 6 , 6-tetramethy lpiperidin-4-y l)succinate ; bis( 1 -oxyl-2 ,2,6, 6-tetramethy lpiperidin-4-yl)adipate ; bis( 1 -oxyl-2 ,2 ,6 , 6-tetramethy lpiperidin-4-yl)sebacate ; bis( 1 -oxyl-2 ,2,6, 6-tetramethy lpiperidin-4-y l)n-butylmalonate ; bis( 1 -oxyl-2 ,2,6 , 6-tetramethy lpiperidin-4-y l)phthalate ; bis( 1 -oxyl-2 ,2,6, 6-tetramethy lpiperidin-4-y l)isophthalate ; bis( 1 -oxyl-2 ,2 , 6 , 6-tetramethy lpiperidin-4-y l)terephthalate ; bis( 1 -oxyl-2 ,2,6 , 6-tetramethy lpiperidin-4-y l)hexahydroterephthalate ; N , N ' -bis( 1 -oxyl-2 ,2,6, 6-tetramethy lpiperidin-4-y l)adipamide ; N-( 1 -oxy 1-2 ,2 , 6 , 6-tetramethy lpiperidin-4-y l)-caprolactam; N-( 1 -oxyl-2 ,2 , 6 , 6-tetramethy lpiperidin-4-y l)-dodecy lsuccinimide ; 2,4, 6-tris- [N-buty l-N-( 1 -oxyl-2 ,2,6, 6-tetramethy lpiperidin-4-yl)] -s-triazine ; 4,4' -ethy lenebis (l-oxyl-2,2,6, 6-tetramethy lpiperazin-3 -one) ; and the like. It is preferred that one member of the combination employed in the practice of the present invention be 4-amino-2, 2, 6, 6-tetramethy 1-piperidiny loxy (4-amino- TEMPO), 4-oxo-2, 2, 6, 6-tetramethy lpiperidiny loxy (4-oxo-TEMPO), 4-hydroxy- 2,2,6,6-tetramethylpiperidinyloxy (4-hydroxy-TEMPO), or 2,2,6,6-tetramethyl- piperidinyloxy (TEMPO). Blends of two or more of the foregoing, e.g., 4-amino-TEMPO and 4-oxo- TEMPO, can also be employed. Such stable nitroxide free radical compounds can be prepared by known methods. (See, for example, U.S. Patent Numbers 3,163,677; 3,334,103; 3,372,182; 3,422,144; 3,494,930; 3,502,692; 3,873,564; 3,966,711; and 4,665,185; which are incorporated herein by reference.) They are suitable for use over a wide range of temperatures, but distillation temperatures employed with the ethylenically unsaturated monomers that are stabilized by the process of the present invention typically range from about 60 °C to about 180°C, preferably from about 70 °C to about 165°C, and, more preferably, from about 80°C to about 150°C. Such distillations are generally performed at an absolute pressure in the range of about 10 to about 1,200 mm of Hg. As pointed out above, the quinones/hydroquinones that are used in combination with the stable nitroxide free radical compounds in the practice of the present invention can be para-quinone, para-hydroquinone, ortho-quinone, ortho- hydroquinone, or derivatives of any of the foregoing. Thus, they can be represented as having the following structural formulae: where R 8 , Rg, R 10 , and R u are independently selected from the group consisting of hydrogen, alkyl, amino, alkoxy, aryl, cyano, halogen, hydroxyl, nitro, SO 2 Ar, COOH, SO 3 H, COOR 12 , NHCOR 12 , OCOR 12 , and the like, where R 12 is alkyl, preferably of from 1 to 5 carbon atoms, and Ar is aryl. Additionally, any of R 8 , R 9 , R 10 , and R π can be taken together with an adjacent R group to form one or more ring structures, preferably having 5 or 6 members and preferably aromatic. Such ring structures may also be substitated at one or more positions with groups such as alkyl, alkenyl, amino, alkoxy, aryl, cyano, halogen, hydroxyl, nitro, SO 2 Ar, COOH. SO 3 H, COOR 12 , NHCOR 12 , OCOR 12 , and the like. As examples of such quinones/hydroquinones may be listed ortho-quinone, para-quinone, β-naphthoquinone, α-naphthoquinone, anthraquinone, 2-amino-1.4- naphthoquinone, 2-methyl-l,4-naphthoquinone, 2-chloro-l,4-naphthoquinone, 2- hydroxy-1 ,4-naphthoquinone, 2-methoxy-l ,4-naphthoquinone, 4-methoxy-l ,2- naphthoquinone, 4-amino-l,2-naphthoquinone, l,2-naphthoquinone-4-sulfonate. 4- anilino-l ,2-naphthoquinone, 2-methyl-3-bromo-l,4-naphthoquinone, phthiocol. lin- naphthindazole-4 , 9-quinone , 1 -methy l-/ -naphthotriazole-4 , 9-quinone , 6-bromo- 1,2- naphthoquinone, 3-nitro-l,2-naphthoquinone, 2-phenyl-l,4-benzoquinone, 2,3- dimethyl-l,4-naphthoquinone, fumigatin, spinulosin, embelin, rapanone, perezone, hydroxyperezone, perezinone, polyporic acid, atromentin, muscarufin, thelephoric acid, lawsone, juglone, plumbagin, lapachol, α-lapachone, β-lapachone, 2-hydroxy- 3(β,β-dimethylvinyl)-l ,4-naphthoquinone, lomatiol, dehydro- β-lapachone, isolomatiol, durmione, allodurmione, 2,5-di-t-butyl-l,4-benzoquinone, 2,6-di-t-butyl- 1,4-benzoquinone, 2, 3, 5, 6-tetramethy 1-1,4-benzoquinone, corresponding hydroquinones, and the like. Where any of R g , R 9 , R 10 , and R n are alkyl, they are preferably alkyl of from 1 to 15 carbon atoms, e.g. , methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, and the like, and isomers thereof, e.g., t-butyl, 2-ethylhexyl, and the like. It is more preferred that R 8 through R π be lower alkyl (or heteroatom-substitated lower alkyl) of one to five carbon atoms (e.g. , methyl, ethyl, propyl, butyl, pentyl, and isomers thereof). As employed herein, the term "alkyl" is intended to include "cycloalkyl", preferably containing 5 or 6 carbon atoms, e.g., cyclohexyl or cycloheptyl. Such cycloalkyl groups may also be substitated. Where any of R 8 , R,, R 10 , and R n are amino, they can be primary, secondary, or tertiary amino. Any alkyl groups attached to the nitrogen atom may have from 1 to 15 carbon atoms, preferably from 1 to 5 carbon atoms, as described above for alkyl. Where any of R g , Rg, R 10 , and R n are alkoxy, they are preferably alkoxy of from 1 to 15 carbon atoms, e.g. , methoxy, ethoxy, propoxy, butoxy, pentoxy, hexoxy, heptoxy, octoxy, nonoxy, decoxy, undecoxy, dodecoxy, tridecoxy, tetradecoxy, pentadecoxy, and the like, and isomers thereof, e.g., t-butoxy, 2- ethylhexoxy, and the like. It is more preferred that R 8 through R n be lower alkoxy (or heteroatom-substitated lower alkoxy) of one to five carbon atoms (e.g. , methoxy, ethoxy, propoxy, butoxy, pentoxy, and isomers thereof). Where any of R 8 , R^ R 10 , and R n are aryl, they are preferably aryl of from 6 to 12 carbon atoms, e.g. phenyl, naphthyl, anthryl, phenanthryl, and the like, which may be substituted or unsubstitated. It is preferred that R 8 , R 9 , R 10 , and R n be selected from the group consisting of hydrogen and alkyl, preferably alkyl of from one to five carbon atoms, or that they form naphthyl, anthryl, or phenanthryl groups with the quinone/hydroquinone moiety. The ethylenically unsaturated monomer, the premature polymerization of which is an object of the present invention, can be any such monomer for which unintended polymerization during its manufacture, storage, and/or distribution is a problem. Among those monomers that will benefit from the practice of the present invention are: styrene, α-methylstyrene, styrene sulfonic acid, vinyltoluene, divinylbenzenes, polyvinylbenzenes, alkylated styrene, 2-vinylpyridine, acrylonitrile, methacrylonitrile, methyl aery late, ethyl aery late, methyl methacrylate, ethyl methacrylate, acrylic acid, methacrylic acid, butadiene, chloroprene, isoprene, and the like. The ethylenically unsaturated monomers will not necessarily be stabilized indefinitely by the presence of the inhibitor blend, especially when the monomers are heated as in distillation, but they can be considered to be stabilized as long as there is a measurable increase in the time for which they can be heated before the onset of polymerization. Those skilled in the art will understand that, if desired, additional free radical scavengers can be included in the stabilized compositions and the methods for preparing them that are the subject of the present invention. For example, air or O 2 , as disclosed in U.S. Patent Numbers 5.545,782 and 5,545,786, can be added, as can the aromatic nitro compounds disclosed in U.S. Patent Number 5,254,760, the dihetero-substitated benzene compounds having at least one transferable hydrogen, e.g., a quinone derivative such as the mono-methyl-ether of hydroquinone disclosed in European Patent Application 0 765 856 Al, the iron compounds disclosed in WO98/25872 and other inhibitors, e.g. , phenolics and certain inorganic salts, well- known to those skilled in the art. The polymerization inhibitor composition can be introduced into the monomer to be protected by any conventional method. It can be added as a concentrated solution in suitable solvents just upstream from the point of desired application by any suitable means. In addition, the individual inhibiting components can be injected separately into the distillation train along with the incoming feed or through separate entry points, provided there is an efficient distribution of the inhibitors. Since the inhibitors are gradually depleted during the distillation operation, it is generally advantageous to maintain the appropriate amount of the inhibitor mixture in the distillation apparatas by adding inhibitors during the course of the distillation process. Adding inhibitors can be done either on a generally continuous basis or intermittently, in order to maintain the concentration of inhibitor mixture above the minimum required level. The advantages and the important features of the present invention will be more apparent from the following examples. EXAMPLES Procedure for Dynamic Reboiler Test with Feed Shut-Off Preparation of Feed Solution. T-Butylcatechol (TBC) is removed from commercially available styrene by distillation under vacuum. Removal of TBC is verified by caustic titration. The desired amount of inhibitor(s) is added to this TBC-free styrene either directly or by first making a concentrated solution of the inhibitor in TBC-free styrene followed by further dilution with TBC-free styrene. Procedure for Dynamic Reboiler Test. A quantity of the Feed Solution containing inhibitor (blend) at the desired charge (stated as a wt/wt total inhibitor to styrene) is added to a round-bottom flask (the "Pot") and heated to the desired temperature (usually 116° C) and brought to reflux by adjusting the pressure/vacuum. Once the Pot contents are at temperature, a continuous stream of fresh Feed Solution is begun at a rate that will add the volume of the initial Pot solution to the Pot over a period of time called the residence time (typically one hour). At the same time that the fresh Feed Solution flow is begun, the Bottoms Stream flow is also begun. The Bottoms Stream is solution in the Pot that is removed at the same rate as the fresh Feed Solution is added. The equal flows of Feed and Bottoms streams cause the quantity in the Pot to remain constant over the time of the experiment while allowing continuous replenishment of inhibitor. This procedure simulates the way inhibitors are used in a distillation train of a plant producing vinyl monomers. The experiment continues with flow in and out of the Pot for a specified period of time, typically seven hours. Samples are collected hourly from the Bottoms Stream. These samples are analyzed for polymer content via the methanol turbidity method. The amount of polymer in the samples is an indication of effectiveness of the inhibitor being tested. Procedure for Feed Shut-Off. At the end of the Reboiler Test Run (typically seven hours), a sample is collected from the Bottoms Stream. This sample corresponds to Feed Shut-Off Time = 0 minutes. The flows of fresh Feed Solution and Bottoms Stream are stopped. The vacuum and temperatare are monitored and adjusted to maintain boiling at the desired temperatare of the experiment. Samples are periodically removed from the Pot (typically every five minutes). These samples are analyzed for polymer content via the methanol turbidity method. Data during this time is used to generate the "Feed Shut-Off Curve" for the run. A less steep slope in the Feed Shut-Off Curve (slower rate of polymer production over time) indicates a more effective inhibiting system in the event of a loss of feed in the plant. A longer period of time before initiation of significant polymer formation is also an indication of a more effective inhibiting system in the event of a loss of feed in the plant. A preferred system will have a long delay prior to initiation of polymer formation followed by a slow rate of polymer production once initiated. The above procedure is carried out using 4-oxo-TEMPO (A) alone and in combination with 2,6-di-t-butyl-l,4-benzoquinone (B), 2,5-di-t-butyl-l,4- hydroquinone (C), and 2,5-di-t-butyl-l,4-benzoquinone (D). The results are shown in Figures 1 and 2 and clearly indicate the improvement that is realized by employing the combination of the present invention, as opposed to 4-oxo-TEMPO alone. The data for the graphs of Figures 1 and 2 are shown in Table 1. A is 4-oxo-TEMPO, B is 2,6-di-t-butyl-l,4-benzoquinone, C is 2,5-di-t-butyl-l,4-hydroquinone, D is 2,5-di-t-butyl-l,4-benzoquinone. In view of the many changes and modifications that can be made without departing from principles underlying the invention, reference should be made to the appended claims for an understanding of the scope of the protection to be afforded the invention.

Claims: CLAIMS What is claimed is: 1. A method for inhibiting the premature polymerization of ethylenically 5 unsatarated monomers comprising adding to said monomers an effective amount of a mixture comprising: A) at least one stable hindered nitroxyl compound having the structural formula: x | 1 x | 2 R - C . , C -R 1 I N ' R I R 4 2 ' 3 O* 10 wherein R and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl; and X x and X 2 (1) are independently selected from the group consisting of halogen, cyano, COOR 7 , -S- i5 COR 7 , -OCOR 7 , wherein R 7 is alkyl or aryl, amido. -S-C 6 H 5 , carbonyl, alkenyl. or alkyl of 1 to 15 carbon atoms, or (2) taken together, form a ring structare with the nitrogen; and B) at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para-hydroquinone, and derivatives of the 0 foregoing. 2. The method of claim 1 wherein the stable hindered nitroxyl compound is of the structural formula: wherein R λ and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl, and the portion represents the atoms necessary to form a five-, six-, or seven-membered heterocyclic ring. 3. The method of claim 2 wherein the stable hindered nitroxyl compound is 4- amino-2 ,2 , 6 , 6-tetramethy lpiperidiny loxy . 4. The method of claim 2 wherein the stable hindered nitroxyl compound is 4- oxo-2 ,2,6, 6-tetramethy lpiperidiny loxy . 5. The method of claim 2 wherein the stable hindered nitroxyl compound is 4- hy droxy-2 ,2 , 6 , 6-tetramethy lpiperidiny loxy . 6. The method of claim 2 wherein the stable hindered nitroxyl compound is a blend of 4-amino-2, 2, 6, 6-tetramethy lpiperidiny loxy and 4-oxo-2,2,6,6- tetramethy lpiperidiny loxy . 7. The method of claim 1 wherein the ethylenically unsaturated monomer is selected from the group consisting of styrene, α-methylstyrene, styrene sulfonic acid, vinyltoluene, divinylbenzenes, polyvmylbenzenes, alkylated styrene, 2-vinylpyridine, acrylonitrile, methacrylonitrile, methyl acrylate, ethyl acrylate, methyl methacrylate, 5 ethyl methacrylate, acrylic acid, methacrylic acid, butadiene, chloroprene, and isoprene. 8. The method of claim 7 wherein the ethylenically unsatarated monomer is styrene. 10 9. The method of claim 8 wherein the stable hindered nitroxyl compound is 4- amino-2 ,2,6, 6-tetramethy lpiperidiny loxy . 10. The method of claim 8 wherein the stable hindered nitroxyl compound is 4- i5 oxo-2,2,6, 6-tetramethy lpiperidiny loxy . 11. The method of claim 8 wherein the stable hindered nitroxyl compound is 4- hy droxy-2 ,2,6, 6-tetramethy lpiperidinyloxy . 20 12. The method of claim 8 wherein the stable hindered nitroxyl compound is a blend of 4-amino-2,2,6,6-tetramethylpiperidinyloxy and 4-oxo-2, 2,6,6- tetramethy lpiperidinyloxy . 13. The method of claim 2 wherein the the ethylenically unsatarated monomer is selected from the group consisting of styrene, α-methylstyrene, styrene sulfonic acid, vinyltoluene, divinylbenzenes, polyvmylbenzenes, alkylated styrene. 2-vinylpyridine, aery lonitr ile, methacrylonitrile, methyl acrylate, ethyl acrylate, methyl methacrylate, 5 ethyl methacrylate, acrylic acid, methacrylic acid, butadiene, chloroprene, and isoprene. 14. The method of claim 13 wherein the ethylenically unsatarated monomer is styrene. 10 15. The method of claim 14 wherein the stable hindered nitroxyl compound is 4- amino-2 ,2 , 6 , 6-tetramethy lpiperidiny loxy . 16. The method of claim 14 wherein the stable hindered nitroxyl compound is 4- i5 oxo-2, 2, 6, 6-tetramethy lpiperidiny loxy. 17. The method of claim 14 wherein the stable hindered nitroxyl compound is 4- hy droxy-2 ,2,6, 6-tetramethy lpiperidinyloxy . 20 18. The method of claim 14 wherein the stable hindered nitroxyl compound is a blend of 4-amino-2,2,6,6-tetramethylpiperidinyloxy and 4-oxo-2,2,6.6- tetramethy lpiperidiny loxy . 19. The method of claim 1 wherein the quinone/hydroquinone is: where R 8 , Rg, R 10 , and R n are independently selected from the group consisting of hydrogen, alkyl, amino, alkoxy, aryl, cyano, halogen, hydroxyl, nitro, SO 2 Ar, COOH, SO 3 H, COOR 12 , NHCOR 12 , OCOR 12 where R 12 is alkyl, or any of R 8 , Rg, R 10 , and R π is taken together with an adjacent R group to form one or more ring structures. 20. The method of claim 19 wherein R 8 , Rg, R 10 , and R n are independently selected from the group consisting of hydrogen and alkyl or any of R 8 , Rg, R 10 . and R n is taken together with an adjacent R group to form one or more ring structures. 21. The method of claim 20 wherein the quinone/hydroquinone is selected from the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l,4- benzoquinone, 2,5-di-t-butyl-l,4-hydroquinone, and mixtures thereof. 5 22. The method of claim 15 wherein the quinone/hydroquinone is selected from the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l,4- benzoquinone, 2,5-di-t-butyl-l,4-hydroquinone, and mixtures thereof. 23. The method of claim 16 wherein the quinone/hydroquinone is selected from ιo the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l,4- benzoquinone, 2,5-di-t-butyl-l,4-hydroquinone, and mixtures thereof. 24. The method of claim 17 wherein the quinone/hydroquinone is selected from the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l,4- i5 benzoquinone, 2,5-di-t-butyl-l,4-hydroquinone, and mixtures thereof. 25. The method of claim 18 wherein the quinone/hydroquinone is selected from the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l,4- benzoquinone, 2,5-di-t-butyl-l,4-hydroquinone, and mixtures thereof. 0 26. A composition comprising: (A) an ethylenically unsatarated monomer, and (B) an effective inhibiting amount, to prevent premature polymerization of the ethylenically unsaturated monomer, of a mixture of (a) at least one stable hindered nitroxyl compound having the structural formula: wherein R x and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl; and X j and X 2 (1) are independently selected from the group consisting of halogen, cyano, COOR 7 , -S- COR 7 , -OCOR 7 , wherein R 7 is alkyl or aryl, amido, -S-C 6 H 5 , carbonyl, alkenyl, or alkyl of 1 to 15 carbon atoms, or (2) taken together, form a ring structare with the nitrogen; and (b) at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para-hydroquinone, and derivatives of the foregoing. 27. The composition of claim 26 wherein the stable hindered nitroxyl compound is of the structural formula: R N P R 2 I R 3 o* wherein R l and R 4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substitated alkyl and R 2 and R 3 are independently selected from the group consisting of alkyl and heteroatom-substitated alkyl, and the portion represents the atoms necessary to form a five-, six-, or seven-membered heterocyclic ring. 10 28. The composition of claim 27 wherein the stable hindered nitroxyl compound is 4-amino-2 ,2,6 , 6-tetramethy lpiperidinyloxy . 29. The composition of claim 27 wherein the stable hindered nitroxyl compound is 4-oxo-2 ,2 , 6 , 6-tetramethy lpiperidinyloxy . 15 30. The composition of claim 27 wherein the stable hindered nitroxyl compound is 4-hydroxy-2 ,2 , 6 , 6-tetramethy lpiperidinyloxy . 31. The composition of claim 27 wherein the stable hindered nitroxyl compound is 0 a blend of 4-amino-2,2,6,6-tetramethylpiperidinyloxy and 4-oxo-2,2,6,6- tetramethy lpiperidiny loxy . 32. The composition of claim 26 wherein the ethylenically unsatarated monomer is selected from the group consisting of styrene, α-methylstyrene, styrene sulfonic acid, vinyltoluene, divinylbenzenes, polyvmylbenzenes, alkylated styrene, 2-vinylpyridine, acrylonitrile, methacrylonitrile, methyl acrylate, ethyl acrylate, methyl methacrylate, ethyl methacrylate, acrylic acid, methacrylic acid, butadiene, chloroprene, and isoprene. 33. The composition of claim 32 wherein the ethylenically unsatarated monomer is styrene. 34. The composition of claim 33 wherein the stable hindered nitroxyl compound is 4-amino-2 ,2,6, 6-tetramethy lpiperidiny loxy . 35. The composition of claim 33 wherein the stable hindered nitroxyl compound is 4-oxo-2 ,2,6, 6-tetramethy lpiperidiny loxy . 36. The composition of claim 33 wherein the stable hindered nitroxyl compound is 4-hy droxy-2 ,2,6 , 6-tetramethy lpiperidiny loxy . 37. The composition of claim 33 wherein the stable hindered nitroxyl compound is a blend of 4-amino-2,2,6,6-tetramethylpiperidinyloxy and 4-oxo-2,2,6,6- tetramethy lpiperidinyloxy. 38. The composition of claim 27 wherein the the ethylenically unsatarated monomer is selected from the group consisting of styrene, α-methylstyrene, styrene sulfonic acid, vinyltoluene, divinylbenzenes, polyvmylbenzenes, alkylated styrene, 2- vinylpyridine, acrylonitrile, methacrylonitrile. methyl acrylate, ethyl acrylate, methyl methacrylate, ethyl methacrylate, acrylic acid, methacrylic acid, butadiene, chloroprene, and isoprene. 39. The composition of claim 38 wherein the ethylenically unsatarated monomer is styrene. 40. The composition of claim 39 wherein the stable hindered nitroxyl compound is 4-amino-2 ,2,6, 6-tetramethy lpiperidiny loxy . 41. The composition of claim 39 wherein the stable hindered nitroxyl compound is 4-oxo-2 ,2 , 6 , 6-tetramethy lpiperidiny loxy . 42. The composition of claim 39 wherein the stable hindered nitroxyl compound is 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy. 43. The composition of claim 39 wherein the stable hindered nitroxyl compound is a blend of 4-amino-2, 2, 6, 6-tetramethy lpiperidiny loxy and 4-oxo-2, 2,6,6- tetramethy lpiperidinyloxy . 44. The composition of claim 26 wherein the quinone/hydroquinone is: where R 8 , Rg, R 10 , and R π are independently selected from the group consisting of hydrogen, alkyl, amino, alkoxy, aryl, cyano, halogen, hydroxyl, nitro, SO 2 Ar, COOH, SO 3 H, COOR j2 , NHCOR 12 , OCOR 12 where R 12 is alkyl, or any of Rg, R,, R 10 , and R n is taken together with an adjacent R group to form one or more ring structares. 45. The composition of claim 44 wherein R 8 , Rg, R 10 , and R n are independently selected from the group consisting of hydrogen and alkyl or any of R 8 , Rg, R 10 , and R π is taken together with an adjacent R group to form one or more ring structares. 46. The composition of claim 45 wherein the wherein the quinone/hydroquinone is selected from the group consisting of 2,6-di-t-butyl-l ,4-benzoquinone, 2,5-di-t-butyl- 1 ,4-benzoquinone, 2,5-di-t-butyl-l,4-hydroquinone, and mixtures thereof. 5 47. The composition of claim 40 wherein the quinone/hydroquinone is selected from the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l ,4- benzoquinone, 2,5-di-t-butyl-l ,4-hydroquinone, and mixtures thereof. 48. The composition of claim 41 wherein the quinone/hydroquinone is selected ιo from the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l ,4- benzoquinone, 2,5-di-t-butyl-l ,4-hydroquinone, and mixtures thereof. 49. The composition of claim 42 wherein the quinone/hydroquinone is selected from the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l,4- i5 benzoquinone, 2,5-di-t-butyl-l,4-hydroquinone, and mixtures thereof. 50. The composition of claim 43 wherein the quinone/hydroquinone is selected from the group consisting of 2,6-di-t-butyl-l,4-benzoquinone, 2,5-di-t-butyl-l,4- benzoquinone, 2,5-di-t-butyl-l,4-hydroquinone, and mixtures thereof. 0

Inventors: ABRUSCATO GERALD J, BENAGE BRIGITTE, BONNELL LEO, GEELAN BRENDAN J, ABRUSCATO, GERALD, J., BENAGE, BRIGITTE, BONNELL, LEO, GEELAN, BRENDAN, J.
Applicants: CROMPTON CORP, CROMPTON CORPORATION
Application year: 2000
Main classification: C07B63
IPC codes: C07B63, C07C7, C07C15, C08F2